id sid tid token lemma pos cord-325328-3l3jznkj 1 1 key key JJ cord-325328-3l3jznkj 1 2 : : : cord-325328-3l3jznkj 1 3 cord-325328 cord-325328 NNP cord-325328-3l3jznkj 1 4 - - HYPH cord-325328-3l3jznkj 1 5 3l3jznkj 3l3jznkj NNP cord-325328-3l3jznkj 1 6 authors author NNS cord-325328-3l3jznkj 1 7 : : : cord-325328-3l3jznkj 1 8 Holbrook Holbrook NNP cord-325328-3l3jznkj 1 9 , , , cord-325328-3l3jznkj 1 10 Stephen Stephen NNP cord-325328-3l3jznkj 1 11 R R NNP cord-325328-3l3jznkj 1 12 title title NN cord-325328-3l3jznkj 1 13 : : : cord-325328-3l3jznkj 1 14 RNA RNA NNP cord-325328-3l3jznkj 1 15 structure structure NN cord-325328-3l3jznkj 1 16 : : : cord-325328-3l3jznkj 2 1 the the DT cord-325328-3l3jznkj 2 2 long long JJ cord-325328-3l3jznkj 2 3 and and CC cord-325328-3l3jznkj 2 4 the the DT cord-325328-3l3jznkj 2 5 short short NN cord-325328-3l3jznkj 2 6 of of IN cord-325328-3l3jznkj 2 7 it -PRON- PRP cord-325328-3l3jznkj 2 8 date date NN cord-325328-3l3jznkj 2 9 : : : cord-325328-3l3jznkj 2 10 2005 2005 CD cord-325328-3l3jznkj 2 11 - - HYPH cord-325328-3l3jznkj 2 12 05 05 CD cord-325328-3l3jznkj 2 13 - - HYPH cord-325328-3l3jznkj 2 14 16 16 CD cord-325328-3l3jznkj 2 15 journal journal NN cord-325328-3l3jznkj 2 16 : : : cord-325328-3l3jznkj 3 1 Curr Curr NNP cord-325328-3l3jznkj 3 2 Opin Opin NNP cord-325328-3l3jznkj 3 3 Struct Struct NNP cord-325328-3l3jznkj 3 4 Biol Biol NNP cord-325328-3l3jznkj 3 5 DOI DOI NNP cord-325328-3l3jznkj 3 6 : : : cord-325328-3l3jznkj 3 7 10.1016 10.1016 CD cord-325328-3l3jznkj 3 8 / / SYM cord-325328-3l3jznkj 3 9 j.sbi.2005.04.005 j.sbi.2005.04.005 NN cord-325328-3l3jznkj 3 10 sha sha NNP cord-325328-3l3jznkj 3 11 : : : cord-325328-3l3jznkj 4 1 66bad98f0d51b374c6e3f7f0b1c380726e61e38d 66bad98f0d51b374c6e3f7f0b1c380726e61e38d CD cord-325328-3l3jznkj 4 2 doc_id doc_id CD cord-325328-3l3jznkj 4 3 : : : cord-325328-3l3jznkj 4 4 325328 325328 CD cord-325328-3l3jznkj 4 5 cord_uid cord_uid NNS cord-325328-3l3jznkj 4 6 : : : cord-325328-3l3jznkj 5 1 3l3jznkj 3l3jznkj NNP cord-325328-3l3jznkj 6 1 The the DT cord-325328-3l3jznkj 6 2 database database NN cord-325328-3l3jznkj 6 3 of of IN cord-325328-3l3jznkj 6 4 RNA RNA NNP cord-325328-3l3jznkj 6 5 structure structure NN cord-325328-3l3jznkj 6 6 has have VBZ cord-325328-3l3jznkj 6 7 grown grow VBN cord-325328-3l3jznkj 6 8 tremendously tremendously RB cord-325328-3l3jznkj 6 9 since since IN cord-325328-3l3jznkj 6 10 the the DT cord-325328-3l3jznkj 6 11 crystal crystal NN cord-325328-3l3jznkj 6 12 structure structure NN cord-325328-3l3jznkj 6 13 analyses analysis NNS cord-325328-3l3jznkj 6 14 of of IN cord-325328-3l3jznkj 6 15 ribosomal ribosomal JJ cord-325328-3l3jznkj 6 16 subunits subunit NNS cord-325328-3l3jznkj 6 17 in in IN cord-325328-3l3jznkj 6 18 2000–2001 2000–2001 CD cord-325328-3l3jznkj 6 19 . . . cord-325328-3l3jznkj 7 1 During during IN cord-325328-3l3jznkj 7 2 the the DT cord-325328-3l3jznkj 7 3 past past JJ cord-325328-3l3jznkj 7 4 year year NN cord-325328-3l3jznkj 7 5 , , , cord-325328-3l3jznkj 7 6 the the DT cord-325328-3l3jznkj 7 7 trend trend NN cord-325328-3l3jznkj 7 8 toward toward IN cord-325328-3l3jznkj 7 9 determining determine VBG cord-325328-3l3jznkj 7 10 the the DT cord-325328-3l3jznkj 7 11 structure structure NN cord-325328-3l3jznkj 7 12 of of IN cord-325328-3l3jznkj 7 13 large large JJ cord-325328-3l3jznkj 7 14 , , , cord-325328-3l3jznkj 7 15 complex complex JJ cord-325328-3l3jznkj 7 16 biological biological JJ cord-325328-3l3jznkj 7 17 RNAs rna NNS cord-325328-3l3jznkj 7 18 has have VBZ cord-325328-3l3jznkj 7 19 accelerated accelerate VBN cord-325328-3l3jznkj 7 20 , , , cord-325328-3l3jznkj 7 21 with with IN cord-325328-3l3jznkj 7 22 the the DT cord-325328-3l3jznkj 7 23 analysis analysis NN cord-325328-3l3jznkj 7 24 of of IN cord-325328-3l3jznkj 7 25 three three CD cord-325328-3l3jznkj 7 26 intact intact JJ cord-325328-3l3jznkj 7 27 group group NN cord-325328-3l3jznkj 7 28 I -PRON- PRP cord-325328-3l3jznkj 7 29 introns intron NNS cord-325328-3l3jznkj 7 30 , , , cord-325328-3l3jznkj 7 31 A- a- NN cord-325328-3l3jznkj 7 32 and and CC cord-325328-3l3jznkj 7 33 B b NN cord-325328-3l3jznkj 7 34 - - HYPH cord-325328-3l3jznkj 7 35 type type NN cord-325328-3l3jznkj 7 36 ribonuclease ribonuclease NN cord-325328-3l3jznkj 7 37 P p NN cord-325328-3l3jznkj 7 38 RNAs rna NNS cord-325328-3l3jznkj 7 39 , , , cord-325328-3l3jznkj 7 40 a a DT cord-325328-3l3jznkj 7 41 riboswitch riboswitch NN cord-325328-3l3jznkj 7 42 – – : cord-325328-3l3jznkj 7 43 substrate substrate NN cord-325328-3l3jznkj 7 44 complex complex NN cord-325328-3l3jznkj 7 45 and and CC cord-325328-3l3jznkj 7 46 other other JJ cord-325328-3l3jznkj 7 47 structures structure NNS cord-325328-3l3jznkj 7 48 . . . cord-325328-3l3jznkj 8 1 The the DT cord-325328-3l3jznkj 8 2 growing grow VBG cord-325328-3l3jznkj 8 3 database database NN cord-325328-3l3jznkj 8 4 of of IN cord-325328-3l3jznkj 8 5 RNA RNA NNP cord-325328-3l3jznkj 8 6 structures structure NNS cord-325328-3l3jznkj 8 7 , , , cord-325328-3l3jznkj 8 8 coupled couple VBN cord-325328-3l3jznkj 8 9 with with IN cord-325328-3l3jznkj 8 10 efforts effort NNS cord-325328-3l3jznkj 8 11 directed direct VBN cord-325328-3l3jznkj 8 12 at at IN cord-325328-3l3jznkj 8 13 the the DT cord-325328-3l3jznkj 8 14 standardization standardization NN cord-325328-3l3jznkj 8 15 of of IN cord-325328-3l3jznkj 8 16 nomenclature nomenclature NN cord-325328-3l3jznkj 8 17 and and CC cord-325328-3l3jznkj 8 18 classification classification NN cord-325328-3l3jznkj 8 19 of of IN cord-325328-3l3jznkj 8 20 motifs motif NNS cord-325328-3l3jznkj 8 21 , , , cord-325328-3l3jznkj 8 22 has have VBZ cord-325328-3l3jznkj 8 23 resulted result VBN cord-325328-3l3jznkj 8 24 in in IN cord-325328-3l3jznkj 8 25 the the DT cord-325328-3l3jznkj 8 26 identification identification NN cord-325328-3l3jznkj 8 27 and and CC cord-325328-3l3jznkj 8 28 characterization characterization NN cord-325328-3l3jznkj 8 29 of of IN cord-325328-3l3jznkj 8 30 numerous numerous JJ cord-325328-3l3jznkj 8 31 RNA RNA NNP cord-325328-3l3jznkj 8 32 secondary secondary JJ cord-325328-3l3jznkj 8 33 and and CC cord-325328-3l3jznkj 8 34 tertiary tertiary JJ cord-325328-3l3jznkj 8 35 structure structure NN cord-325328-3l3jznkj 8 36 motifs motif NNS cord-325328-3l3jznkj 8 37 . . . cord-325328-3l3jznkj 9 1 Because because IN cord-325328-3l3jznkj 9 2 a a DT cord-325328-3l3jznkj 9 3 large large JJ cord-325328-3l3jznkj 9 4 proportion proportion NN cord-325328-3l3jznkj 9 5 of of IN cord-325328-3l3jznkj 9 6 RNA RNA NNP cord-325328-3l3jznkj 9 7 structure structure NN cord-325328-3l3jznkj 9 8 can can MD cord-325328-3l3jznkj 9 9 now now RB cord-325328-3l3jznkj 9 10 be be VB cord-325328-3l3jznkj 9 11 shown show VBN cord-325328-3l3jznkj 9 12 to to TO cord-325328-3l3jznkj 9 13 be be VB cord-325328-3l3jznkj 9 14 composed compose VBN cord-325328-3l3jznkj 9 15 of of IN cord-325328-3l3jznkj 9 16 these these DT cord-325328-3l3jznkj 9 17 recurring recur VBG cord-325328-3l3jznkj 9 18 structural structural JJ cord-325328-3l3jznkj 9 19 motifs motif NNS cord-325328-3l3jznkj 9 20 , , , cord-325328-3l3jznkj 9 21 a a DT cord-325328-3l3jznkj 9 22 view view NN cord-325328-3l3jznkj 9 23 of of IN cord-325328-3l3jznkj 9 24 RNA RNA NNP cord-325328-3l3jznkj 9 25 as as IN cord-325328-3l3jznkj 9 26 a a DT cord-325328-3l3jznkj 9 27 modular modular JJ cord-325328-3l3jznkj 9 28 structure structure NN cord-325328-3l3jznkj 9 29 built build VBN cord-325328-3l3jznkj 9 30 from from IN cord-325328-3l3jznkj 9 31 a a DT cord-325328-3l3jznkj 9 32 combination combination NN cord-325328-3l3jznkj 9 33 of of IN cord-325328-3l3jznkj 9 34 these these DT cord-325328-3l3jznkj 9 35 building building NN cord-325328-3l3jznkj 9 36 blocks block NNS cord-325328-3l3jznkj 9 37 and and CC cord-325328-3l3jznkj 9 38 tertiary tertiary JJ cord-325328-3l3jznkj 9 39 linkers linker NNS cord-325328-3l3jznkj 9 40 is be VBZ cord-325328-3l3jznkj 9 41 beginning begin VBG cord-325328-3l3jznkj 9 42 to to TO cord-325328-3l3jznkj 9 43 emerge emerge VB cord-325328-3l3jznkj 9 44 . . . cord-325328-3l3jznkj 10 1 At at IN cord-325328-3l3jznkj 10 2 the the DT cord-325328-3l3jznkj 10 3 same same JJ cord-325328-3l3jznkj 10 4 time time NN cord-325328-3l3jznkj 10 5 , , , cord-325328-3l3jznkj 10 6 however however RB cord-325328-3l3jznkj 10 7 , , , cord-325328-3l3jznkj 10 8 more more RBR cord-325328-3l3jznkj 10 9 detailed detailed JJ cord-325328-3l3jznkj 10 10 analysis analysis NN cord-325328-3l3jznkj 10 11 of of IN cord-325328-3l3jznkj 10 12 water water NN cord-325328-3l3jznkj 10 13 , , , cord-325328-3l3jznkj 10 14 metal metal NN cord-325328-3l3jznkj 10 15 , , , cord-325328-3l3jznkj 10 16 ligand ligand NN cord-325328-3l3jznkj 10 17 and and CC cord-325328-3l3jznkj 10 18 protein protein NN cord-325328-3l3jznkj 10 19 binding bind VBG cord-325328-3l3jznkj 10 20 to to IN cord-325328-3l3jznkj 10 21 RNA RNA NNP cord-325328-3l3jznkj 10 22 is be VBZ cord-325328-3l3jznkj 10 23 revealing reveal VBG cord-325328-3l3jznkj 10 24 the the DT cord-325328-3l3jznkj 10 25 effect effect NN cord-325328-3l3jznkj 10 26 of of IN cord-325328-3l3jznkj 10 27 these these DT cord-325328-3l3jznkj 10 28 moieties moiety NNS cord-325328-3l3jznkj 10 29 on on IN cord-325328-3l3jznkj 10 30 folding folding NN cord-325328-3l3jznkj 10 31 and and CC cord-325328-3l3jznkj 10 32 structure structure NN cord-325328-3l3jznkj 10 33 formation formation NN cord-325328-3l3jznkj 10 34 . . . cord-325328-3l3jznkj 11 1 The the DT cord-325328-3l3jznkj 11 2 balance balance NN cord-325328-3l3jznkj 11 3 between between IN cord-325328-3l3jznkj 11 4 the the DT cord-325328-3l3jznkj 11 5 views view NNS cord-325328-3l3jznkj 11 6 of of IN cord-325328-3l3jznkj 11 7 RNA RNA NNP cord-325328-3l3jznkj 11 8 structure structure NN cord-325328-3l3jznkj 11 9 either either CC cord-325328-3l3jznkj 11 10 as as IN cord-325328-3l3jznkj 11 11 strictly strictly RB cord-325328-3l3jznkj 11 12 a a DT cord-325328-3l3jznkj 11 13 construct construct NN cord-325328-3l3jznkj 11 14 of of IN cord-325328-3l3jznkj 11 15 preformed preformed JJ cord-325328-3l3jznkj 11 16 building building NN cord-325328-3l3jznkj 11 17 blocks block NNS cord-325328-3l3jznkj 11 18 linked link VBN cord-325328-3l3jznkj 11 19 in in IN cord-325328-3l3jznkj 11 20 a a DT cord-325328-3l3jznkj 11 21 limited limited JJ cord-325328-3l3jznkj 11 22 number number NN cord-325328-3l3jznkj 11 23 of of IN cord-325328-3l3jznkj 11 24 ways way NNS cord-325328-3l3jznkj 11 25 or or CC cord-325328-3l3jznkj 11 26 as as IN cord-325328-3l3jznkj 11 27 a a DT cord-325328-3l3jznkj 11 28 flexible flexible JJ cord-325328-3l3jznkj 11 29 polymer polymer NN cord-325328-3l3jznkj 11 30 assuming assume VBG cord-325328-3l3jznkj 11 31 a a DT cord-325328-3l3jznkj 11 32 global global JJ cord-325328-3l3jznkj 11 33 fold fold NN cord-325328-3l3jznkj 11 34 influenced influence VBN cord-325328-3l3jznkj 11 35 by by IN cord-325328-3l3jznkj 11 36 its -PRON- PRP$ cord-325328-3l3jznkj 11 37 environment environment NN cord-325328-3l3jznkj 11 38 will will MD cord-325328-3l3jznkj 11 39 be be VB cord-325328-3l3jznkj 11 40 the the DT cord-325328-3l3jznkj 11 41 focus focus NN cord-325328-3l3jznkj 11 42 of of IN cord-325328-3l3jznkj 11 43 current current JJ cord-325328-3l3jznkj 11 44 and and CC cord-325328-3l3jznkj 11 45 future future JJ cord-325328-3l3jznkj 11 46 RNA RNA NNP cord-325328-3l3jznkj 11 47 structural structural JJ cord-325328-3l3jznkj 11 48 biology biology NN cord-325328-3l3jznkj 11 49 . . . cord-325328-3l3jznkj 12 1 Stephen Stephen NNP cord-325328-3l3jznkj 12 2 R R NNP cord-325328-3l3jznkj 12 3 Holbrook Holbrook NNP cord-325328-3l3jznkj 13 1 The the DT cord-325328-3l3jznkj 13 2 database database NN cord-325328-3l3jznkj 13 3 of of IN cord-325328-3l3jznkj 13 4 RNA RNA NNP cord-325328-3l3jznkj 13 5 structure structure NN cord-325328-3l3jznkj 13 6 has have VBZ cord-325328-3l3jznkj 13 7 grown grow VBN cord-325328-3l3jznkj 13 8 tremendously tremendously RB cord-325328-3l3jznkj 13 9 since since IN cord-325328-3l3jznkj 13 10 the the DT cord-325328-3l3jznkj 13 11 crystal crystal NN cord-325328-3l3jznkj 13 12 structure structure NN cord-325328-3l3jznkj 13 13 analyses analysis NNS cord-325328-3l3jznkj 13 14 of of IN cord-325328-3l3jznkj 13 15 ribosomal ribosomal JJ cord-325328-3l3jznkj 13 16 subunits subunit NNS cord-325328-3l3jznkj 13 17 in in IN cord-325328-3l3jznkj 13 18 [ [ -LRB- cord-325328-3l3jznkj 13 19 2000 2000 CD cord-325328-3l3jznkj 13 20 ] ] -RRB- cord-325328-3l3jznkj 13 21 [ [ -LRB- cord-325328-3l3jznkj 13 22 2001 2001 CD cord-325328-3l3jznkj 13 23 ] ] -RRB- cord-325328-3l3jznkj 13 24 . . . cord-325328-3l3jznkj 14 1 During during IN cord-325328-3l3jznkj 14 2 the the DT cord-325328-3l3jznkj 14 3 past past JJ cord-325328-3l3jznkj 14 4 year year NN cord-325328-3l3jznkj 14 5 , , , cord-325328-3l3jznkj 14 6 the the DT cord-325328-3l3jznkj 14 7 trend trend NN cord-325328-3l3jznkj 14 8 toward toward IN cord-325328-3l3jznkj 14 9 determining determine VBG cord-325328-3l3jznkj 14 10 the the DT cord-325328-3l3jznkj 14 11 structure structure NN cord-325328-3l3jznkj 14 12 of of IN cord-325328-3l3jznkj 14 13 large large JJ cord-325328-3l3jznkj 14 14 , , , cord-325328-3l3jznkj 14 15 complex complex JJ cord-325328-3l3jznkj 14 16 biological biological JJ cord-325328-3l3jznkj 14 17 RNAs rna NNS cord-325328-3l3jznkj 14 18 has have VBZ cord-325328-3l3jznkj 14 19 accelerated accelerate VBN cord-325328-3l3jznkj 14 20 , , , cord-325328-3l3jznkj 14 21 with with IN cord-325328-3l3jznkj 14 22 the the DT cord-325328-3l3jznkj 14 23 analysis analysis NN cord-325328-3l3jznkj 14 24 of of IN cord-325328-3l3jznkj 14 25 three three CD cord-325328-3l3jznkj 14 26 intact intact JJ cord-325328-3l3jznkj 14 27 group group NN cord-325328-3l3jznkj 14 28 I -PRON- PRP cord-325328-3l3jznkj 14 29 introns intron NNS cord-325328-3l3jznkj 14 30 , , , cord-325328-3l3jznkj 14 31 A A NNP cord-325328-3l3jznkj 14 32 - - , cord-325328-3l3jznkj 14 33 and and CC cord-325328-3l3jznkj 14 34 B b NN cord-325328-3l3jznkj 14 35 - - HYPH cord-325328-3l3jznkj 14 36 type type NN cord-325328-3l3jznkj 14 37 ribonuclease ribonuclease NN cord-325328-3l3jznkj 14 38 P p NN cord-325328-3l3jznkj 14 39 RNAs rna NNS cord-325328-3l3jznkj 14 40 , , , cord-325328-3l3jznkj 14 41 a a DT cord-325328-3l3jznkj 14 42 riboswitch riboswitch NN cord-325328-3l3jznkj 14 43 - - HYPH cord-325328-3l3jznkj 14 44 substrate substrate NN cord-325328-3l3jznkj 14 45 complex complex NN cord-325328-3l3jznkj 14 46 and and CC cord-325328-3l3jznkj 14 47 other other JJ cord-325328-3l3jznkj 14 48 structures structure NNS cord-325328-3l3jznkj 14 49 . . . cord-325328-3l3jznkj 15 1 The the DT cord-325328-3l3jznkj 15 2 growing grow VBG cord-325328-3l3jznkj 15 3 database database NN cord-325328-3l3jznkj 15 4 of of IN cord-325328-3l3jznkj 15 5 RNA RNA NNP cord-325328-3l3jznkj 15 6 structures structure NNS cord-325328-3l3jznkj 15 7 , , , cord-325328-3l3jznkj 15 8 coupled couple VBN cord-325328-3l3jznkj 15 9 with with IN cord-325328-3l3jznkj 15 10 efforts effort NNS cord-325328-3l3jznkj 15 11 directed direct VBN cord-325328-3l3jznkj 15 12 at at IN cord-325328-3l3jznkj 15 13 the the DT cord-325328-3l3jznkj 15 14 standardization standardization NN cord-325328-3l3jznkj 15 15 of of IN cord-325328-3l3jznkj 15 16 nomenclature nomenclature NN cord-325328-3l3jznkj 15 17 and and CC cord-325328-3l3jznkj 15 18 classification classification NN cord-325328-3l3jznkj 15 19 of of IN cord-325328-3l3jznkj 15 20 motifs motif NNS cord-325328-3l3jznkj 15 21 , , , cord-325328-3l3jznkj 15 22 has have VBZ cord-325328-3l3jznkj 15 23 resulted result VBN cord-325328-3l3jznkj 15 24 in in IN cord-325328-3l3jznkj 15 25 the the DT cord-325328-3l3jznkj 15 26 identification identification NN cord-325328-3l3jznkj 15 27 and and CC cord-325328-3l3jznkj 15 28 characterization characterization NN cord-325328-3l3jznkj 15 29 of of IN cord-325328-3l3jznkj 15 30 numerous numerous JJ cord-325328-3l3jznkj 15 31 RNA RNA NNP cord-325328-3l3jznkj 15 32 secondary secondary JJ cord-325328-3l3jznkj 15 33 and and CC cord-325328-3l3jznkj 15 34 tertiary tertiary JJ cord-325328-3l3jznkj 15 35 structure structure NN cord-325328-3l3jznkj 15 36 motifs motif NNS cord-325328-3l3jznkj 15 37 . . . cord-325328-3l3jznkj 16 1 Because because IN cord-325328-3l3jznkj 16 2 a a DT cord-325328-3l3jznkj 16 3 large large JJ cord-325328-3l3jznkj 16 4 proportion proportion NN cord-325328-3l3jznkj 16 5 of of IN cord-325328-3l3jznkj 16 6 RNA RNA NNP cord-325328-3l3jznkj 16 7 structure structure NN cord-325328-3l3jznkj 16 8 can can MD cord-325328-3l3jznkj 16 9 now now RB cord-325328-3l3jznkj 16 10 be be VB cord-325328-3l3jznkj 16 11 shown show VBN cord-325328-3l3jznkj 16 12 to to TO cord-325328-3l3jznkj 16 13 be be VB cord-325328-3l3jznkj 16 14 composed compose VBN cord-325328-3l3jznkj 16 15 of of IN cord-325328-3l3jznkj 16 16 these these DT cord-325328-3l3jznkj 16 17 recurring recur VBG cord-325328-3l3jznkj 16 18 structural structural JJ cord-325328-3l3jznkj 16 19 motifs motif NNS cord-325328-3l3jznkj 16 20 , , , cord-325328-3l3jznkj 16 21 a a DT cord-325328-3l3jznkj 16 22 view view NN cord-325328-3l3jznkj 16 23 of of IN cord-325328-3l3jznkj 16 24 RNA RNA NNP cord-325328-3l3jznkj 16 25 as as IN cord-325328-3l3jznkj 16 26 a a DT cord-325328-3l3jznkj 16 27 modular modular JJ cord-325328-3l3jznkj 16 28 structure structure NN cord-325328-3l3jznkj 16 29 built build VBN cord-325328-3l3jznkj 16 30 from from IN cord-325328-3l3jznkj 16 31 a a DT cord-325328-3l3jznkj 16 32 combination combination NN cord-325328-3l3jznkj 16 33 of of IN cord-325328-3l3jznkj 16 34 these these DT cord-325328-3l3jznkj 16 35 building building NN cord-325328-3l3jznkj 16 36 blocks block NNS cord-325328-3l3jznkj 16 37 and and CC cord-325328-3l3jznkj 16 38 tertiary tertiary JJ cord-325328-3l3jznkj 16 39 linkers linker NNS cord-325328-3l3jznkj 16 40 is be VBZ cord-325328-3l3jznkj 16 41 beginning begin VBG cord-325328-3l3jznkj 16 42 to to TO cord-325328-3l3jznkj 16 43 emerge emerge VB cord-325328-3l3jznkj 16 44 . . . cord-325328-3l3jznkj 17 1 At at IN cord-325328-3l3jznkj 17 2 the the DT cord-325328-3l3jznkj 17 3 same same JJ cord-325328-3l3jznkj 17 4 time time NN cord-325328-3l3jznkj 17 5 , , , cord-325328-3l3jznkj 17 6 however however RB cord-325328-3l3jznkj 17 7 , , , cord-325328-3l3jznkj 17 8 more more RBR cord-325328-3l3jznkj 17 9 detailed detailed JJ cord-325328-3l3jznkj 17 10 analysis analysis NN cord-325328-3l3jznkj 17 11 of of IN cord-325328-3l3jznkj 17 12 water water NN cord-325328-3l3jznkj 17 13 , , , cord-325328-3l3jznkj 17 14 metal metal NN cord-325328-3l3jznkj 17 15 , , , cord-325328-3l3jznkj 17 16 ligand ligand NN cord-325328-3l3jznkj 17 17 and and CC cord-325328-3l3jznkj 17 18 protein protein NN cord-325328-3l3jznkj 17 19 binding bind VBG cord-325328-3l3jznkj 17 20 to to IN cord-325328-3l3jznkj 17 21 RNA RNA NNP cord-325328-3l3jznkj 17 22 is be VBZ cord-325328-3l3jznkj 17 23 revealing reveal VBG cord-325328-3l3jznkj 17 24 the the DT cord-325328-3l3jznkj 17 25 effect effect NN cord-325328-3l3jznkj 17 26 of of IN cord-325328-3l3jznkj 17 27 these these DT cord-325328-3l3jznkj 17 28 moieties moiety NNS cord-325328-3l3jznkj 17 29 on on IN cord-325328-3l3jznkj 17 30 folding folding NN cord-325328-3l3jznkj 17 31 and and CC cord-325328-3l3jznkj 17 32 structure structure NN cord-325328-3l3jznkj 17 33 formation formation NN cord-325328-3l3jznkj 17 34 . . . cord-325328-3l3jznkj 18 1 The the DT cord-325328-3l3jznkj 18 2 balance balance NN cord-325328-3l3jznkj 18 3 between between IN cord-325328-3l3jznkj 18 4 the the DT cord-325328-3l3jznkj 18 5 views view NNS cord-325328-3l3jznkj 18 6 of of IN cord-325328-3l3jznkj 18 7 RNA RNA NNP cord-325328-3l3jznkj 18 8 structure structure NN cord-325328-3l3jznkj 18 9 either either CC cord-325328-3l3jznkj 18 10 as as IN cord-325328-3l3jznkj 18 11 strictly strictly RB cord-325328-3l3jznkj 18 12 a a DT cord-325328-3l3jznkj 18 13 construct construct NN cord-325328-3l3jznkj 18 14 of of IN cord-325328-3l3jznkj 18 15 preformed preformed JJ cord-325328-3l3jznkj 18 16 building building NN cord-325328-3l3jznkj 18 17 blocks block NNS cord-325328-3l3jznkj 18 18 linked link VBN cord-325328-3l3jznkj 18 19 in in IN cord-325328-3l3jznkj 18 20 a a DT cord-325328-3l3jznkj 18 21 limited limited JJ cord-325328-3l3jznkj 18 22 number number NN cord-325328-3l3jznkj 18 23 of of IN cord-325328-3l3jznkj 18 24 ways way NNS cord-325328-3l3jznkj 18 25 or or CC cord-325328-3l3jznkj 18 26 as as IN cord-325328-3l3jznkj 18 27 a a DT cord-325328-3l3jznkj 18 28 flexible flexible JJ cord-325328-3l3jznkj 18 29 polymer polymer NN cord-325328-3l3jznkj 18 30 assuming assume VBG cord-325328-3l3jznkj 18 31 a a DT cord-325328-3l3jznkj 18 32 global global JJ cord-325328-3l3jznkj 18 33 fold fold NN cord-325328-3l3jznkj 18 34 influenced influence VBN cord-325328-3l3jznkj 18 35 by by IN cord-325328-3l3jznkj 18 36 its -PRON- PRP$ cord-325328-3l3jznkj 18 37 environment environment NN cord-325328-3l3jznkj 18 38 will will MD cord-325328-3l3jznkj 18 39 be be VB cord-325328-3l3jznkj 18 40 the the DT cord-325328-3l3jznkj 18 41 focus focus NN cord-325328-3l3jznkj 18 42 of of IN cord-325328-3l3jznkj 18 43 current current JJ cord-325328-3l3jznkj 18 44 and and CC cord-325328-3l3jznkj 18 45 future future JJ cord-325328-3l3jznkj 18 46 RNA RNA NNP cord-325328-3l3jznkj 18 47 structural structural JJ cord-325328-3l3jznkj 18 48 biology biology NN cord-325328-3l3jznkj 18 49 . . . cord-325328-3l3jznkj 19 1 Recent recent JJ cord-325328-3l3jznkj 19 2 trends trend NNS cord-325328-3l3jznkj 19 3 in in IN cord-325328-3l3jznkj 19 4 RNA RNA NNP cord-325328-3l3jznkj 19 5 structure structure NN cord-325328-3l3jznkj 19 6 determination determination NN cord-325328-3l3jznkj 19 7 and and CC cord-325328-3l3jznkj 19 8 analysis analysis NN cord-325328-3l3jznkj 19 9 have have VBP cord-325328-3l3jznkj 19 10 accelerated accelerate VBN cord-325328-3l3jznkj 19 11 in in IN cord-325328-3l3jznkj 19 12 two two CD cord-325328-3l3jznkj 19 13 seemingly seemingly RB cord-325328-3l3jznkj 19 14 disparate disparate JJ cord-325328-3l3jznkj 19 15 directions direction NNS cord-325328-3l3jznkj 19 16 : : : cord-325328-3l3jznkj 19 17 the the DT cord-325328-3l3jznkj 19 18 determination determination NN cord-325328-3l3jznkj 19 19 of of IN cord-325328-3l3jznkj 19 20 larger large JJR cord-325328-3l3jznkj 19 21 , , , cord-325328-3l3jznkj 19 22 more more RBR cord-325328-3l3jznkj 19 23 biologically biologically RB cord-325328-3l3jznkj 19 24 relevant relevant JJ cord-325328-3l3jznkj 19 25 RNA RNA NNP cord-325328-3l3jznkj 19 26 structures structure NNS cord-325328-3l3jznkj 19 27 by by IN cord-325328-3l3jznkj 19 28 both both CC cord-325328-3l3jznkj 19 29 X x NN cord-325328-3l3jznkj 19 30 - - NN cord-325328-3l3jznkj 19 31 ray ray NN cord-325328-3l3jznkj 19 32 crystallography crystallography NN cord-325328-3l3jznkj 19 33 and and CC cord-325328-3l3jznkj 19 34 NMR NMR NNP cord-325328-3l3jznkj 19 35 methods method NNS cord-325328-3l3jznkj 19 36 ; ; : cord-325328-3l3jznkj 19 37 and and CC cord-325328-3l3jznkj 19 38 the the DT cord-325328-3l3jznkj 19 39 identification identification NN cord-325328-3l3jznkj 19 40 , , , cord-325328-3l3jznkj 19 41 classification classification NN cord-325328-3l3jznkj 19 42 and and CC cord-325328-3l3jznkj 19 43 characterization characterization NN cord-325328-3l3jznkj 19 44 of of IN cord-325328-3l3jznkj 19 45 the the DT cord-325328-3l3jznkj 19 46 small small JJ cord-325328-3l3jznkj 19 47 , , , cord-325328-3l3jznkj 19 48 ubiquitous ubiquitous JJ cord-325328-3l3jznkj 19 49 structural structural JJ cord-325328-3l3jznkj 19 50 motifs motif NNS cord-325328-3l3jznkj 19 51 found find VBN cord-325328-3l3jznkj 19 52 in in IN cord-325328-3l3jznkj 19 53 these these DT cord-325328-3l3jznkj 19 54 RNA RNA NNP cord-325328-3l3jznkj 19 55 structures structure NNS cord-325328-3l3jznkj 19 56 . . . cord-325328-3l3jznkj 20 1 Surprisingly surprisingly RB cord-325328-3l3jznkj 20 2 , , , cord-325328-3l3jznkj 20 3 these these DT cord-325328-3l3jznkj 20 4 two two CD cord-325328-3l3jznkj 20 5 directions direction NNS cord-325328-3l3jznkj 20 6 are be VBP cord-325328-3l3jznkj 20 7 related relate VBN cord-325328-3l3jznkj 20 8 and and CC cord-325328-3l3jznkj 20 9 are be VBP cord-325328-3l3jznkj 20 10 mutually mutually RB cord-325328-3l3jznkj 20 11 reinfor reinfor JJ cord-325328-3l3jznkj 20 12 - - HYPH cord-325328-3l3jznkj 20 13 cing ce VBG cord-325328-3l3jznkj 20 14 the the DT cord-325328-3l3jznkj 20 15 advancement advancement NN cord-325328-3l3jznkj 20 16 of of IN cord-325328-3l3jznkj 20 17 the the DT cord-325328-3l3jznkj 20 18 field field NN cord-325328-3l3jznkj 20 19 of of IN cord-325328-3l3jznkj 20 20 RNA RNA NNP cord-325328-3l3jznkj 20 21 structural structural JJ cord-325328-3l3jznkj 20 22 biology biology NN cord-325328-3l3jznkj 20 23 . . . cord-325328-3l3jznkj 21 1 Continuing continue VBG cord-325328-3l3jznkj 21 2 improvements improvement NNS cord-325328-3l3jznkj 21 3 in in IN cord-325328-3l3jznkj 21 4 methods method NNS cord-325328-3l3jznkj 21 5 for for IN cord-325328-3l3jznkj 21 6 the the DT cord-325328-3l3jznkj 21 7 synthesis synthesis NN cord-325328-3l3jznkj 21 8 , , , cord-325328-3l3jznkj 21 9 purification purification NN cord-325328-3l3jznkj 21 10 , , , cord-325328-3l3jznkj 21 11 crystallization crystallization NN cord-325328-3l3jznkj 21 12 and and CC cord-325328-3l3jznkj 21 13 derivatization derivatization NN cord-325328-3l3jznkj 21 14 of of IN cord-325328-3l3jznkj 21 15 large large JJ cord-325328-3l3jznkj 21 16 RNA RNA NNP cord-325328-3l3jznkj 21 17 molecules molecule NNS cord-325328-3l3jznkj 21 18 , , , cord-325328-3l3jznkj 21 19 together together RB cord-325328-3l3jznkj 21 20 with with IN cord-325328-3l3jznkj 21 21 technical technical JJ cord-325328-3l3jznkj 21 22 advances advance NNS cord-325328-3l3jznkj 21 23 at at IN cord-325328-3l3jznkj 21 24 and and CC cord-325328-3l3jznkj 21 25 increased increase VBN cord-325328-3l3jznkj 21 26 availability availability NN cord-325328-3l3jznkj 21 27 of of IN cord-325328-3l3jznkj 21 28 synchrotron synchrotron NN cord-325328-3l3jznkj 21 29 X x NN cord-325328-3l3jznkj 21 30 - - NN cord-325328-3l3jznkj 21 31 ray ray NN cord-325328-3l3jznkj 21 32 beamlines beamline NNS cord-325328-3l3jznkj 21 33 , , , cord-325328-3l3jznkj 21 34 and and CC cord-325328-3l3jznkj 21 35 the the DT cord-325328-3l3jznkj 21 36 development development NN cord-325328-3l3jznkj 21 37 of of IN cord-325328-3l3jznkj 21 38 advanced advanced JJ cord-325328-3l3jznkj 21 39 structure structure NN cord-325328-3l3jznkj 21 40 solution solution NN cord-325328-3l3jznkj 21 41 software software NN cord-325328-3l3jznkj 21 42 , , , cord-325328-3l3jznkj 21 43 are be VBP cord-325328-3l3jznkj 21 44 allowing allow VBG cord-325328-3l3jznkj 21 45 more more JJR cord-325328-3l3jznkj 21 46 and and CC cord-325328-3l3jznkj 21 47 larger large JJR cord-325328-3l3jznkj 21 48 RNA RNA NNP cord-325328-3l3jznkj 21 49 structures structure NNS cord-325328-3l3jznkj 21 50 to to TO cord-325328-3l3jznkj 21 51 be be VB cord-325328-3l3jznkj 21 52 determined determine VBN cord-325328-3l3jznkj 21 53 [ [ -LRB- cord-325328-3l3jznkj 21 54 1 1 CD cord-325328-3l3jznkj 21 55 ] ] -RRB- cord-325328-3l3jznkj 21 56 . . . cord-325328-3l3jznkj 22 1 The the DT cord-325328-3l3jznkj 22 2 parallel parallel JJ cord-325328-3l3jznkj 22 3 development development NN cord-325328-3l3jznkj 22 4 of of IN cord-325328-3l3jznkj 22 5 high high JJ cord-325328-3l3jznkj 22 6 - - HYPH cord-325328-3l3jznkj 22 7 resolution resolution NN cord-325328-3l3jznkj 22 8 NMR NMR NNP cord-325328-3l3jznkj 22 9 methods method NNS cord-325328-3l3jznkj 22 10 has have VBZ cord-325328-3l3jznkj 22 11 increased increase VBN cord-325328-3l3jznkj 22 12 the the DT cord-325328-3l3jznkj 22 13 feasible feasible JJ cord-325328-3l3jznkj 22 14 size size NN cord-325328-3l3jznkj 22 15 of of IN cord-325328-3l3jznkj 22 16 RNA RNA NNP cord-325328-3l3jznkj 22 17 structures structure NNS cord-325328-3l3jznkj 22 18 that that WDT cord-325328-3l3jznkj 22 19 can can MD cord-325328-3l3jznkj 22 20 be be VB cord-325328-3l3jznkj 22 21 determined determine VBN cord-325328-3l3jznkj 22 22 , , , cord-325328-3l3jznkj 22 23 as as IN cord-325328-3l3jznkj 22 24 evidenced evidence VBN cord-325328-3l3jznkj 22 25 by by IN cord-325328-3l3jznkj 22 26 the the DT cord-325328-3l3jznkj 22 27 structure structure NN cord-325328-3l3jznkj 22 28 of of IN cord-325328-3l3jznkj 22 29 the the DT cord-325328-3l3jznkj 22 30 101-nucleotide 101-nucleotide CD cord-325328-3l3jznkj 22 31 RNA RNA NNP cord-325328-3l3jznkj 22 32 responsible responsible JJ cord-325328-3l3jznkj 22 33 for for IN cord-325328-3l3jznkj 22 34 signaling signal VBG cord-325328-3l3jznkj 22 35 core core NN cord-325328-3l3jznkj 22 36 encapsidation encapsidation NN cord-325328-3l3jznkj 22 37 in in IN cord-325328-3l3jznkj 22 38 Moloney Moloney NNP cord-325328-3l3jznkj 22 39 murine murine JJ cord-325328-3l3jznkj 22 40 leukemia leukemia NN cord-325328-3l3jznkj 22 41 virus virus NN cord-325328-3l3jznkj 22 42 ( ( -LRB- cord-325328-3l3jznkj 22 43 MMLV MMLV NNP cord-325328-3l3jznkj 22 44 ) ) -RRB- cord-325328-3l3jznkj 22 45 [ [ -LRB- cord-325328-3l3jznkj 22 46 2 2 CD cord-325328-3l3jznkj 22 47 ] ] -RRB- cord-325328-3l3jznkj 22 48 . . . cord-325328-3l3jznkj 23 1 Figure figure NN cord-325328-3l3jznkj 23 2 1 1 CD cord-325328-3l3jznkj 23 3 shows show VBZ cord-325328-3l3jznkj 23 4 the the DT cord-325328-3l3jznkj 23 5 average average JJ cord-325328-3l3jznkj 23 6 size size NN cord-325328-3l3jznkj 23 7 of of IN cord-325328-3l3jznkj 23 8 RNA RNA NNP cord-325328-3l3jznkj 23 9 structures structure NNS cord-325328-3l3jznkj 23 10 determined determine VBN cord-325328-3l3jznkj 23 11 by by IN cord-325328-3l3jznkj 23 12 year year NN cord-325328-3l3jznkj 23 13 , , , cord-325328-3l3jznkj 23 14 as as IN cord-325328-3l3jznkj 23 15 catalogued catalogue VBN cord-325328-3l3jznkj 23 16 in in IN cord-325328-3l3jznkj 23 17 the the DT cord-325328-3l3jznkj 23 18 Nucleic Nucleic NNP cord-325328-3l3jznkj 23 19 Acid acid NN cord-325328-3l3jznkj 23 20 Database database NN cord-325328-3l3jznkj 23 21 ( ( -LRB- cord-325328-3l3jznkj 23 22 NDB ndb NN cord-325328-3l3jznkj 23 23 ) ) -RRB- cord-325328-3l3jznkj 24 1 [ [ -LRB- cord-325328-3l3jznkj 24 2 3 3 CD cord-325328-3l3jznkj 24 3 ] ] -RRB- cord-325328-3l3jznkj 24 4 . . . cord-325328-3l3jznkj 25 1 The the DT cord-325328-3l3jznkj 25 2 solution solution NN cord-325328-3l3jznkj 25 3 of of IN cord-325328-3l3jznkj 25 4 the the DT cord-325328-3l3jznkj 25 5 first first JJ cord-325328-3l3jznkj 25 6 ribosomal ribosomal JJ cord-325328-3l3jznkj 25 7 subunit subunit NN cord-325328-3l3jznkj 25 8 structures structure NNS cord-325328-3l3jznkj 25 9 in in IN cord-325328-3l3jznkj 25 10 2000 2000 CD cord-325328-3l3jznkj 25 11 - - SYM cord-325328-3l3jznkj 25 12 2001 2001 CD cord-325328-3l3jznkj 25 13 demonstrated demonstrate VBD cord-325328-3l3jznkj 25 14 that that IN cord-325328-3l3jznkj 25 15 methods method NNS cord-325328-3l3jznkj 25 16 for for IN cord-325328-3l3jznkj 25 17 the the DT cord-325328-3l3jznkj 25 18 determination determination NN cord-325328-3l3jznkj 25 19 of of IN cord-325328-3l3jznkj 25 20 large large JJ cord-325328-3l3jznkj 25 21 RNA RNA NNP cord-325328-3l3jznkj 25 22 structures structure NNS cord-325328-3l3jznkj 25 23 were be VBD cord-325328-3l3jznkj 25 24 available available JJ cord-325328-3l3jznkj 25 25 . . . cord-325328-3l3jznkj 26 1 These these DT cord-325328-3l3jznkj 26 2 methods method NNS cord-325328-3l3jznkj 26 3 are be VBP cord-325328-3l3jznkj 26 4 now now RB cord-325328-3l3jznkj 26 5 being be VBG cord-325328-3l3jznkj 26 6 widely widely RB cord-325328-3l3jznkj 26 7 applied apply VBN cord-325328-3l3jznkj 26 8 to to IN cord-325328-3l3jznkj 26 9 a a DT cord-325328-3l3jznkj 26 10 variety variety NN cord-325328-3l3jznkj 26 11 of of IN cord-325328-3l3jznkj 26 12 biologically biologically RB cord-325328-3l3jznkj 26 13 important important JJ cord-325328-3l3jznkj 26 14 RNA RNA NNP cord-325328-3l3jznkj 26 15 structure structure NN cord-325328-3l3jznkj 26 16 analyses analysis NNS cord-325328-3l3jznkj 26 17 . . . cord-325328-3l3jznkj 27 1 Structural structural JJ cord-325328-3l3jznkj 27 2 studies study NNS cord-325328-3l3jznkj 27 3 and and CC cord-325328-3l3jznkj 27 4 comparative comparative JJ cord-325328-3l3jznkj 27 5 sequence sequence NN cord-325328-3l3jznkj 27 6 analyses analysis NNS cord-325328-3l3jznkj 27 7 have have VBP cord-325328-3l3jznkj 27 8 suggested suggest VBN cord-325328-3l3jznkj 27 9 that that IN cord-325328-3l3jznkj 27 10 biological biological JJ cord-325328-3l3jznkj 27 11 RNAs rna NNS cord-325328-3l3jznkj 27 12 are be VBP cord-325328-3l3jznkj 27 13 largely largely RB cord-325328-3l3jznkj 27 14 modular modular JJ cord-325328-3l3jznkj 27 15 in in IN cord-325328-3l3jznkj 27 16 nature nature NN cord-325328-3l3jznkj 27 17 , , , cord-325328-3l3jznkj 27 18 composed compose VBN cord-325328-3l3jznkj 27 19 primarily primarily RB cord-325328-3l3jznkj 27 20 of of IN cord-325328-3l3jznkj 27 21 conserved conserve VBN cord-325328-3l3jznkj 27 22 structural structural JJ cord-325328-3l3jznkj 27 23 building building NN cord-325328-3l3jznkj 27 24 blocks block NNS cord-325328-3l3jznkj 27 25 or or CC cord-325328-3l3jznkj 27 26 motifs motif NNS cord-325328-3l3jznkj 27 27 [ [ -LRB- cord-325328-3l3jznkj 27 28 4 4 CD cord-325328-3l3jznkj 27 29 ] ] -RRB- cord-325328-3l3jznkj 27 30 of of IN cord-325328-3l3jznkj 27 31 secondary secondary JJ cord-325328-3l3jznkj 27 32 ( ( -LRB- cord-325328-3l3jznkj 27 33 helices helix NNS cord-325328-3l3jznkj 27 34 , , , cord-325328-3l3jznkj 27 35 and and CC cord-325328-3l3jznkj 27 36 internal internal JJ cord-325328-3l3jznkj 27 37 , , , cord-325328-3l3jznkj 27 38 external external JJ cord-325328-3l3jznkj 27 39 and and CC cord-325328-3l3jznkj 27 40 junction junction NN cord-325328-3l3jznkj 27 41 loops loop NNS cord-325328-3l3jznkj 27 42 ) ) -RRB- cord-325328-3l3jznkj 27 43 and and CC cord-325328-3l3jznkj 27 44 tertiary tertiary JJ cord-325328-3l3jznkj 27 45 ( ( -LRB- cord-325328-3l3jznkj 27 46 coaxial coaxial JJ cord-325328-3l3jznkj 27 47 stacks stack NNS cord-325328-3l3jznkj 27 48 , , , cord-325328-3l3jznkj 27 49 kissing kiss VBG cord-325328-3l3jznkj 27 50 hairpin hairpin JJ cord-325328-3l3jznkj 27 51 loops loop NNS cord-325328-3l3jznkj 27 52 , , , cord-325328-3l3jznkj 27 53 ribose ribose NN cord-325328-3l3jznkj 27 54 zippers zipper NNS cord-325328-3l3jznkj 27 55 , , , cord-325328-3l3jznkj 27 56 etc etc FW cord-325328-3l3jznkj 27 57 . . . cord-325328-3l3jznkj 27 58 ) ) -RRB- cord-325328-3l3jznkj 28 1 structure structure NN cord-325328-3l3jznkj 28 2 . . . cord-325328-3l3jznkj 29 1 Although although IN cord-325328-3l3jznkj 29 2 many many JJ cord-325328-3l3jznkj 29 3 secondary secondary JJ cord-325328-3l3jznkj 29 4 and and CC cord-325328-3l3jznkj 29 5 tertiary tertiary JJ cord-325328-3l3jznkj 29 6 structure structure NN cord-325328-3l3jznkj 29 7 motifs motif NNS cord-325328-3l3jznkj 29 8 have have VBP cord-325328-3l3jznkj 29 9 been be VBN cord-325328-3l3jznkj 29 10 identified identify VBN cord-325328-3l3jznkj 29 11 and and CC cord-325328-3l3jznkj 29 12 characterized characterize VBN cord-325328-3l3jznkj 29 13 in in IN cord-325328-3l3jznkj 29 14 terms term NNS cord-325328-3l3jznkj 29 15 of of IN cord-325328-3l3jznkj 29 16 sequence sequence NN cord-325328-3l3jznkj 29 17 preference preference NN cord-325328-3l3jznkj 29 18 , , , cord-325328-3l3jznkj 29 19 structural structural JJ cord-325328-3l3jznkj 29 20 constraints constraint NNS cord-325328-3l3jznkj 29 21 , , , cord-325328-3l3jznkj 29 22 energetics energetic NNS cord-325328-3l3jznkj 29 23 and and CC cord-325328-3l3jznkj 29 24 dynamics dynamic NNS cord-325328-3l3jznkj 29 25 , , , cord-325328-3l3jznkj 29 26 it -PRON- PRP cord-325328-3l3jznkj 29 27 is be VBZ cord-325328-3l3jznkj 29 28 an an DT cord-325328-3l3jznkj 29 29 open open JJ cord-325328-3l3jznkj 29 30 question question NN cord-325328-3l3jznkj 29 31 as as IN cord-325328-3l3jznkj 29 32 to to IN cord-325328-3l3jznkj 29 33 whether whether IN cord-325328-3l3jznkj 29 34 we -PRON- PRP cord-325328-3l3jznkj 29 35 have have VBP cord-325328-3l3jznkj 29 36 observed observe VBN cord-325328-3l3jznkj 29 37 a a DT cord-325328-3l3jznkj 29 38 large large JJ cord-325328-3l3jznkj 29 39 or or CC cord-325328-3l3jznkj 29 40 small small JJ cord-325328-3l3jznkj 29 41 fraction fraction NN cord-325328-3l3jznkj 29 42 of of IN cord-325328-3l3jznkj 29 43 the the DT cord-325328-3l3jznkj 29 44 universe universe NN cord-325328-3l3jznkj 29 45 of of IN cord-325328-3l3jznkj 29 46 motifs motif NNS cord-325328-3l3jznkj 29 47 . . . cord-325328-3l3jznkj 30 1 Immediately immediately RB cord-325328-3l3jznkj 30 2 after after IN cord-325328-3l3jznkj 30 3 the the DT cord-325328-3l3jznkj 30 4 structure structure NN cord-325328-3l3jznkj 30 5 determination determination NN cord-325328-3l3jznkj 30 6 of of IN cord-325328-3l3jznkj 30 7 the the DT cord-325328-3l3jznkj 30 8 large large JJ cord-325328-3l3jznkj 30 9 [ [ -LRB- cord-325328-3l3jznkj 30 10 5 5 CD cord-325328-3l3jznkj 30 11 , , , cord-325328-3l3jznkj 30 12 6 6 CD cord-325328-3l3jznkj 30 13 ] ] -RRB- cord-325328-3l3jznkj 30 14 and and CC cord-325328-3l3jznkj 30 15 small small JJ cord-325328-3l3jznkj 30 16 [ [ -LRB- cord-325328-3l3jznkj 30 17 7 7 CD cord-325328-3l3jznkj 30 18 ] ] -RRB- cord-325328-3l3jznkj 30 19 ribosomal ribosomal JJ cord-325328-3l3jznkj 30 20 subunits subunit NNS cord-325328-3l3jznkj 30 21 , , , cord-325328-3l3jznkj 30 22 inspection inspection NN cord-325328-3l3jznkj 30 23 of of IN cord-325328-3l3jznkj 30 24 the the DT cord-325328-3l3jznkj 30 25 rRNA rRNA NNP cord-325328-3l3jznkj 30 26 structures structure NNS cord-325328-3l3jznkj 30 27 suggested suggest VBD cord-325328-3l3jznkj 30 28 that that IN cord-325328-3l3jznkj 30 29 they -PRON- PRP cord-325328-3l3jznkj 30 30 consisted consist VBD cord-325328-3l3jznkj 30 31 mainly mainly RB cord-325328-3l3jznkj 30 32 of of IN cord-325328-3l3jznkj 30 33 known know VBN cord-325328-3l3jznkj 30 34 RNA RNA NNP cord-325328-3l3jznkj 30 35 structural structural JJ cord-325328-3l3jznkj 30 36 elements element NNS cord-325328-3l3jznkj 30 37 ( ( -LRB- cord-325328-3l3jznkj 30 38 i.e. i.e. FW cord-325328-3l3jznkj 30 39 few few JJ cord-325328-3l3jznkj 30 40 , , , cord-325328-3l3jznkj 30 41 if if IN cord-325328-3l3jznkj 30 42 any any DT cord-325328-3l3jznkj 30 43 , , , cord-325328-3l3jznkj 30 44 novel novel JJ cord-325328-3l3jznkj 30 45 motifs motif NNS cord-325328-3l3jznkj 30 46 were be VBD cord-325328-3l3jznkj 30 47 observed observe VBN cord-325328-3l3jznkj 30 48 ) ) -RRB- cord-325328-3l3jznkj 30 49 . . . cord-325328-3l3jznkj 31 1 More more RBR cord-325328-3l3jznkj 31 2 detailed detailed JJ cord-325328-3l3jznkj 31 3 studies study NNS cord-325328-3l3jznkj 31 4 are be VBP cord-325328-3l3jznkj 31 5 showing show VBG cord-325328-3l3jznkj 31 6 , , , cord-325328-3l3jznkj 31 7 however however RB cord-325328-3l3jznkj 31 8 , , , cord-325328-3l3jznkj 31 9 that that IN cord-325328-3l3jznkj 31 10 there there EX cord-325328-3l3jznkj 31 11 is be VBZ cord-325328-3l3jznkj 31 12 an an DT cord-325328-3l3jznkj 31 13 abundance abundance NN cord-325328-3l3jznkj 31 14 of of IN cord-325328-3l3jznkj 31 15 information information NN cord-325328-3l3jznkj 31 16 still still RB cord-325328-3l3jznkj 31 17 to to TO cord-325328-3l3jznkj 31 18 be be VB cord-325328-3l3jznkj 31 19 extracted extract VBN cord-325328-3l3jznkj 31 20 from from IN cord-325328-3l3jznkj 31 21 these these DT cord-325328-3l3jznkj 31 22 structures structure NNS cord-325328-3l3jznkj 31 23 and and CC cord-325328-3l3jznkj 31 24 correlated correlate VBD cord-325328-3l3jznkj 31 25 with with IN cord-325328-3l3jznkj 31 26 RNA RNA NNP cord-325328-3l3jznkj 31 27 structural structural JJ cord-325328-3l3jznkj 31 28 features feature NNS cord-325328-3l3jznkj 31 29 observed observe VBN cord-325328-3l3jznkj 31 30 in in IN cord-325328-3l3jznkj 31 31 other other JJ cord-325328-3l3jznkj 31 32 biomolecules biomolecule NNS cord-325328-3l3jznkj 31 33 . . . cord-325328-3l3jznkj 32 1 The the DT cord-325328-3l3jznkj 32 2 determination determination NN cord-325328-3l3jznkj 32 3 of of IN cord-325328-3l3jznkj 32 4 large large JJ cord-325328-3l3jznkj 32 5 RNA RNA NNP cord-325328-3l3jznkj 32 6 structures structure NNS cord-325328-3l3jznkj 32 7 in in IN cord-325328-3l3jznkj 32 8 many many JJ cord-325328-3l3jznkj 32 9 cases case NNS cord-325328-3l3jznkj 32 10 has have VBZ cord-325328-3l3jznkj 32 11 benefited benefit VBN cord-325328-3l3jznkj 32 12 from from IN cord-325328-3l3jznkj 32 13 the the DT cord-325328-3l3jznkj 32 14 design design NN cord-325328-3l3jznkj 32 15 of of IN cord-325328-3l3jznkj 32 16 more more JJR cord-325328-3l3jznkj 32 17 crystallizable crystallizable JJ cord-325328-3l3jznkj 32 18 sequences sequence NNS cord-325328-3l3jznkj 32 19 , , , cord-325328-3l3jznkj 32 20 based base VBN cord-325328-3l3jznkj 32 21 on on IN cord-325328-3l3jznkj 32 22 an an DT cord-325328-3l3jznkj 32 23 understanding understanding NN cord-325328-3l3jznkj 32 24 of of IN cord-325328-3l3jznkj 32 25 RNA RNA NNP cord-325328-3l3jznkj 32 26 structural structural JJ cord-325328-3l3jznkj 32 27 motifs motif NNS cord-325328-3l3jznkj 32 28 . . . cord-325328-3l3jznkj 33 1 Reciprocally reciprocally RB cord-325328-3l3jznkj 33 2 , , , cord-325328-3l3jznkj 33 3 the the DT cord-325328-3l3jznkj 33 4 identification identification NN cord-325328-3l3jznkj 33 5 and and CC cord-325328-3l3jznkj 33 6 characterization characterization NN cord-325328-3l3jznkj 33 7 of of IN cord-325328-3l3jznkj 33 8 known know VBN cord-325328-3l3jznkj 33 9 and and CC cord-325328-3l3jznkj 33 10 novel novel NN cord-325328-3l3jznkj 33 11 RNA RNA NNP cord-325328-3l3jznkj 33 12 motifs motif NNS cord-325328-3l3jznkj 33 13 are be VBP cord-325328-3l3jznkj 33 14 greatly greatly RB cord-325328-3l3jznkj 33 15 advanced advance VBN cord-325328-3l3jznkj 33 16 by by IN cord-325328-3l3jznkj 33 17 the the DT cord-325328-3l3jznkj 33 18 structure structure NN cord-325328-3l3jznkj 33 19 determination determination NN cord-325328-3l3jznkj 33 20 of of IN cord-325328-3l3jznkj 33 21 new new JJ cord-325328-3l3jznkj 33 22 types type NNS cord-325328-3l3jznkj 33 23 of of IN cord-325328-3l3jznkj 33 24 large large JJ cord-325328-3l3jznkj 33 25 biological biological JJ cord-325328-3l3jznkj 33 26 RNAs rna NNS cord-325328-3l3jznkj 33 27 . . . cord-325328-3l3jznkj 34 1 In in IN cord-325328-3l3jznkj 34 2 this this DT cord-325328-3l3jznkj 34 3 review review NN cord-325328-3l3jznkj 34 4 , , , cord-325328-3l3jznkj 34 5 recent recent JJ cord-325328-3l3jznkj 34 6 structure structure NN cord-325328-3l3jznkj 34 7 determinations determination NNS cord-325328-3l3jznkj 34 8 of of IN cord-325328-3l3jznkj 34 9 several several JJ cord-325328-3l3jznkj 34 10 biological biological JJ cord-325328-3l3jznkj 34 11 RNAs rna NNS cord-325328-3l3jznkj 34 12 are be VBP cord-325328-3l3jznkj 34 13 presented present VBN cord-325328-3l3jznkj 34 14 and and CC cord-325328-3l3jznkj 34 15 described describe VBN cord-325328-3l3jznkj 34 16 . . . cord-325328-3l3jznkj 35 1 The the DT cord-325328-3l3jznkj 35 2 secondary secondary JJ cord-325328-3l3jznkj 35 3 structure structure NN cord-325328-3l3jznkj 35 4 and and CC cord-325328-3l3jznkj 35 5 tertiary tertiary JJ cord-325328-3l3jznkj 35 6 interaction interaction NN cord-325328-3l3jznkj 35 7 motifs motif NNS cord-325328-3l3jznkj 35 8 of of IN cord-325328-3l3jznkj 35 9 these these DT cord-325328-3l3jznkj 35 10 RNAs rna NNS cord-325328-3l3jznkj 35 11 are be VBP cord-325328-3l3jznkj 35 12 analyzed analyze VBN cord-325328-3l3jznkj 35 13 in in IN cord-325328-3l3jznkj 35 14 terms term NNS cord-325328-3l3jznkj 35 15 of of IN cord-325328-3l3jznkj 35 16 our -PRON- PRP$ cord-325328-3l3jznkj 35 17 current current JJ cord-325328-3l3jznkj 35 18 knowledge knowledge NN cord-325328-3l3jznkj 35 19 of of IN cord-325328-3l3jznkj 35 20 RNA RNA NNP cord-325328-3l3jznkj 35 21 motifs motif NNS cord-325328-3l3jznkj 35 22 and and CC cord-325328-3l3jznkj 35 23 the the DT cord-325328-3l3jznkj 35 24 novel novel JJ cord-325328-3l3jznkj 35 25 motifs motif NNS cord-325328-3l3jznkj 35 26 observed observe VBN cord-325328-3l3jznkj 35 27 in in IN cord-325328-3l3jznkj 35 28 these these DT cord-325328-3l3jznkj 35 29 structures structure NNS cord-325328-3l3jznkj 35 30 . . . cord-325328-3l3jznkj 36 1 The the DT cord-325328-3l3jznkj 36 2 ability ability NN cord-325328-3l3jznkj 36 3 to to TO cord-325328-3l3jznkj 36 4 partition partition VB cord-325328-3l3jznkj 36 5 large large JJ cord-325328-3l3jznkj 36 6 RNA RNA NNP cord-325328-3l3jznkj 36 7 structures structure NNS cord-325328-3l3jznkj 36 8 into into IN cord-325328-3l3jznkj 36 9 well well RB cord-325328-3l3jznkj 36 10 - - HYPH cord-325328-3l3jznkj 36 11 characterized characterize VBN cord-325328-3l3jznkj 36 12 subunits subunit NNS cord-325328-3l3jznkj 36 13 , , , cord-325328-3l3jznkj 36 14 or or CC cord-325328-3l3jznkj 36 15 motifs motif NNS cord-325328-3l3jznkj 36 16 , , , cord-325328-3l3jznkj 36 17 is be VBZ cord-325328-3l3jznkj 36 18 an an DT cord-325328-3l3jznkj 36 19 important important JJ cord-325328-3l3jznkj 36 20 advance advance NN cord-325328-3l3jznkj 36 21 in in IN cord-325328-3l3jznkj 36 22 understanding understand VBG cord-325328-3l3jznkj 36 23 the the DT cord-325328-3l3jznkj 36 24 relationship relationship NN cord-325328-3l3jznkj 36 25 between between IN cord-325328-3l3jznkj 36 26 structure structure NN cord-325328-3l3jznkj 36 27 and and CC cord-325328-3l3jznkj 36 28 function function NN cord-325328-3l3jznkj 36 29 , , , cord-325328-3l3jznkj 36 30 and and CC cord-325328-3l3jznkj 36 31 in in IN cord-325328-3l3jznkj 36 32 RNA RNA NNP cord-325328-3l3jznkj 36 33 structure structure NN cord-325328-3l3jznkj 36 34 prediction prediction NN cord-325328-3l3jznkj 36 35 and and CC cord-325328-3l3jznkj 36 36 design design NN cord-325328-3l3jznkj 36 37 . . . cord-325328-3l3jznkj 37 1 In in IN cord-325328-3l3jznkj 37 2 addition addition NN cord-325328-3l3jznkj 37 3 to to IN cord-325328-3l3jznkj 37 4 the the DT cord-325328-3l3jznkj 37 5 updated update VBN cord-325328-3l3jznkj 37 6 ribosomal ribosomal JJ cord-325328-3l3jznkj 37 7 subunit subunit NN cord-325328-3l3jznkj 37 8 models model NNS cord-325328-3l3jznkj 37 9 , , , cord-325328-3l3jznkj 37 10 with with IN cord-325328-3l3jznkj 37 11 better well JJR cord-325328-3l3jznkj 37 12 resolution resolution NN cord-325328-3l3jznkj 37 13 , , , cord-325328-3l3jznkj 37 14 and and CC cord-325328-3l3jznkj 37 15 the the DT cord-325328-3l3jznkj 37 16 refinement refinement NN cord-325328-3l3jznkj 37 17 and and CC cord-325328-3l3jznkj 37 18 analysis analysis NN cord-325328-3l3jznkj 37 19 of of IN cord-325328-3l3jznkj 37 20 rRNA rrna JJ cord-325328-3l3jznkj 37 21 interactions interaction NNS cord-325328-3l3jznkj 37 22 with with IN cord-325328-3l3jznkj 37 23 protein protein NN cord-325328-3l3jznkj 37 24 and and CC cord-325328-3l3jznkj 37 25 metal metal NN cord-325328-3l3jznkj 37 26 [ [ -LRB- cord-325328-3l3jznkj 37 27 8 8 CD cord-325328-3l3jznkj 37 28 , , , cord-325328-3l3jznkj 37 29 9 9 CD cord-325328-3l3jznkj 37 30 ] ] -RRB- cord-325328-3l3jznkj 37 31 , , , cord-325328-3l3jznkj 37 32 many many JJ cord-325328-3l3jznkj 37 33 structures structure NNS cord-325328-3l3jznkj 37 34 of of IN cord-325328-3l3jznkj 37 35 the the DT cord-325328-3l3jznkj 37 36 ribosomal ribosomal JJ cord-325328-3l3jznkj 37 37 subunits subunit NNS cord-325328-3l3jznkj 37 38 bound bind VBN cord-325328-3l3jznkj 37 39 to to IN cord-325328-3l3jznkj 37 40 antibiotics antibiotic NNS cord-325328-3l3jznkj 37 41 [ [ -LRB- cord-325328-3l3jznkj 37 42 10 10 CD cord-325328-3l3jznkj 37 43 ] ] -RRB- cord-325328-3l3jznkj 37 44 and and CC cord-325328-3l3jznkj 37 45 other other JJ cord-325328-3l3jznkj 37 46 ligands ligand NNS cord-325328-3l3jznkj 37 47 [ [ -LRB- cord-325328-3l3jznkj 37 48 11 11 CD cord-325328-3l3jznkj 37 49 , , , cord-325328-3l3jznkj 37 50 12 12 CD cord-325328-3l3jznkj 37 51 ] ] -RRB- cord-325328-3l3jznkj 37 52 have have VBP cord-325328-3l3jznkj 37 53 been be VBN cord-325328-3l3jznkj 37 54 deposited deposit VBN cord-325328-3l3jznkj 37 55 in in IN cord-325328-3l3jznkj 37 56 the the DT cord-325328-3l3jznkj 37 57 Protein Protein NNP cord-325328-3l3jznkj 37 58 Data Data NNP cord-325328-3l3jznkj 37 59 Bank Bank NNP cord-325328-3l3jznkj 37 60 ( ( -LRB- cord-325328-3l3jznkj 37 61 PDB PDB NNP cord-325328-3l3jznkj 37 62 ) ) -RRB- cord-325328-3l3jznkj 37 63 . . . cord-325328-3l3jznkj 38 1 Other other JJ cord-325328-3l3jznkj 38 2 biological biological JJ cord-325328-3l3jznkj 38 3 RNA RNA NNP cord-325328-3l3jznkj 38 4 structures structure NNS cord-325328-3l3jznkj 38 5 that that WDT cord-325328-3l3jznkj 38 6 have have VBP cord-325328-3l3jznkj 38 7 recently recently RB cord-325328-3l3jznkj 38 8 been be VBN cord-325328-3l3jznkj 38 9 determined determine VBN cord-325328-3l3jznkj 38 10 are be VBP cord-325328-3l3jznkj 38 11 summarized summarize VBN cord-325328-3l3jznkj 38 12 in in IN cord-325328-3l3jznkj 38 13 Table Table NNP cord-325328-3l3jznkj 38 14 1 1 CD cord-325328-3l3jznkj 38 15 . . . cord-325328-3l3jznkj 39 1 Three three CD cord-325328-3l3jznkj 39 2 group group NN cord-325328-3l3jznkj 39 3 I -PRON- PRP cord-325328-3l3jznkj 39 4 introns intron NNS cord-325328-3l3jznkj 39 5 are be VBP cord-325328-3l3jznkj 39 6 among among IN cord-325328-3l3jznkj 39 7 recently recently RB cord-325328-3l3jznkj 39 8 solved solve VBN cord-325328-3l3jznkj 39 9 , , , cord-325328-3l3jznkj 39 10 new new JJ cord-325328-3l3jznkj 39 11 , , , cord-325328-3l3jznkj 39 12 high high JJ cord-325328-3l3jznkj 39 13 - - HYPH cord-325328-3l3jznkj 39 14 impact impact NN cord-325328-3l3jznkj 39 15 , , , cord-325328-3l3jznkj 39 16 biological biological JJ cord-325328-3l3jznkj 39 17 RNA RNA NNP cord-325328-3l3jznkj 39 18 structures structure NNS cord-325328-3l3jznkj 39 19 : : : cord-325328-3l3jznkj 39 20 an an DT cord-325328-3l3jznkj 39 21 intact intact JJ cord-325328-3l3jznkj 39 22 , , , cord-325328-3l3jznkj 39 23 selfsplicing selfsplice VBG cord-325328-3l3jznkj 39 24 group group NN cord-325328-3l3jznkj 39 25 I -PRON- PRP cord-325328-3l3jznkj 39 26 intron intron VBP cord-325328-3l3jznkj 39 27 with with IN cord-325328-3l3jznkj 39 28 both both CC cord-325328-3l3jznkj 39 29 its -PRON- PRP$ cord-325328-3l3jznkj 39 30 5 5 CD cord-325328-3l3jznkj 39 31 0 0 CD cord-325328-3l3jznkj 39 32 and and CC cord-325328-3l3jznkj 39 33 3 3 CD cord-325328-3l3jznkj 39 34 0 0 CD cord-325328-3l3jznkj 39 35 exons exon NNS cord-325328-3l3jznkj 39 36 from from IN cord-325328-3l3jznkj 39 37 the the DT cord-325328-3l3jznkj 39 38 purple purple JJ cord-325328-3l3jznkj 39 39 bacterium bacterium NN cord-325328-3l3jznkj 39 40 Azoarcus Azoarcus NNP cord-325328-3l3jznkj 39 41 sp sp NNP cord-325328-3l3jznkj 39 42 [ [ -LRB- cord-325328-3l3jznkj 39 43 13 13 CD cord-325328-3l3jznkj 39 44 , , , cord-325328-3l3jznkj 39 45 14 14 CD cord-325328-3l3jznkj 39 46 ] ] -RRB- cord-325328-3l3jznkj 39 47 , , , cord-325328-3l3jznkj 39 48 a a DT cord-325328-3l3jznkj 39 49 group group NN cord-325328-3l3jznkj 39 50 I -PRON- PRP cord-325328-3l3jznkj 39 51 ribozyme ribozyme NN cord-325328-3l3jznkj 39 52 - - HYPH cord-325328-3l3jznkj 39 53 product product NN cord-325328-3l3jznkj 39 54 complex complex NN cord-325328-3l3jznkj 39 55 from from IN cord-325328-3l3jznkj 39 56 phage phage NN cord-325328-3l3jznkj 39 57 Twort Twort NNP cord-325328-3l3jznkj 39 58 [ [ -LRB- cord-325328-3l3jznkj 39 59 15 15 CD cord-325328-3l3jznkj 39 60 ] ] -RRB- cord-325328-3l3jznkj 39 61 and and CC cord-325328-3l3jznkj 39 62 a a DT cord-325328-3l3jznkj 39 63 group group NN cord-325328-3l3jznkj 39 64 I -PRON- PRP cord-325328-3l3jznkj 39 65 intron intron NN cord-325328-3l3jznkj 39 66 ribozyme ribozyme VBZ cord-325328-3l3jznkj 39 67 from from IN cord-325328-3l3jznkj 39 68 Tetrahymena Tetrahymena NNP cord-325328-3l3jznkj 39 69 [ [ -LRB- cord-325328-3l3jznkj 39 70 16 16 CD cord-325328-3l3jznkj 39 71 ] ] -RRB- cord-325328-3l3jznkj 39 72 . . . cord-325328-3l3jznkj 40 1 Other other JJ cord-325328-3l3jznkj 40 2 structures structure NNS cord-325328-3l3jznkj 40 3 include include VBP cord-325328-3l3jznkj 40 4 the the DT cord-325328-3l3jznkj 40 5 specificity specificity NN cord-325328-3l3jznkj 40 6 domains domain NNS cord-325328-3l3jznkj 40 7 of of IN cord-325328-3l3jznkj 40 8 both both CC cord-325328-3l3jznkj 40 9 A- a- XX cord-325328-3l3jznkj 40 10 [ [ -LRB- cord-325328-3l3jznkj 40 11 17 17 CD cord-325328-3l3jznkj 40 12 ] ] -RRB- cord-325328-3l3jznkj 40 13 and and CC cord-325328-3l3jznkj 40 14 B b NN cord-325328-3l3jznkj 40 15 - - HYPH cord-325328-3l3jznkj 40 16 type type NN cord-325328-3l3jznkj 40 17 ribonuclease ribonuclease NN cord-325328-3l3jznkj 40 18 P p NN cord-325328-3l3jznkj 40 19 [ [ -LRB- cord-325328-3l3jznkj 40 20 18 18 CD cord-325328-3l3jznkj 40 21 ] ] -RRB- cord-325328-3l3jznkj 40 22 ; ; : cord-325328-3l3jznkj 40 23 RNAs rna NNS cord-325328-3l3jznkj 40 24 corresponding correspond VBG cord-325328-3l3jznkj 40 25 to to IN cord-325328-3l3jznkj 40 26 a a DT cord-325328-3l3jznkj 40 27 guanine guanine NN cord-325328-3l3jznkj 40 28 - - HYPH cord-325328-3l3jznkj 40 29 responsive responsive JJ cord-325328-3l3jznkj 40 30 riboswitch riboswitch NN cord-325328-3l3jznkj 40 31 ( ( -LRB- cord-325328-3l3jznkj 40 32 xpt xpt NNP cord-325328-3l3jznkj 40 33 ) ) -RRB- cord-325328-3l3jznkj 40 34 complexed complexe VBN cord-325328-3l3jznkj 40 35 with with IN cord-325328-3l3jznkj 40 36 guanine guanine NN cord-325328-3l3jznkj 40 37 [ [ -LRB- cord-325328-3l3jznkj 40 38 19 19 CD cord-325328-3l3jznkj 40 39 ] ] -RRB- cord-325328-3l3jznkj 40 40 or or CC cord-325328-3l3jznkj 40 41 hypoxanthine hypoxanthine JJ cord-325328-3l3jznkj 40 42 [ [ -LRB- cord-325328-3l3jznkj 40 43 20 20 CD cord-325328-3l3jznkj 40 44 ] ] -RRB- cord-325328-3l3jznkj 40 45 , , , cord-325328-3l3jznkj 40 46 and and CC cord-325328-3l3jznkj 40 47 an an DT cord-325328-3l3jznkj 40 48 adenosine adenosine NN cord-325328-3l3jznkj 40 49 - - HYPH cord-325328-3l3jznkj 40 50 responsive responsive JJ cord-325328-3l3jznkj 40 51 riboswitch riboswitch NN cord-325328-3l3jznkj 40 52 ( ( -LRB- cord-325328-3l3jznkj 40 53 add add VB cord-325328-3l3jznkj 40 54 ) ) -RRB- cord-325328-3l3jznkj 40 55 complexed complexe VBN cord-325328-3l3jznkj 40 56 with with IN cord-325328-3l3jznkj 40 57 adenosine adenosine NN cord-325328-3l3jznkj 40 58 [ [ -LRB- cord-325328-3l3jznkj 40 59 19 19 CD cord-325328-3l3jznkj 40 60 ] ] -RRB- cord-325328-3l3jznkj 40 61 ; ; : cord-325328-3l3jznkj 40 62 a a DT cord-325328-3l3jznkj 40 63 highly highly RB cord-325328-3l3jznkj 40 64 conserved conserve VBN cord-325328-3l3jznkj 40 65 stem stem NN cord-325328-3l3jznkj 40 66 - - HYPH cord-325328-3l3jznkj 40 67 loop loop NN cord-325328-3l3jznkj 40 68 motif motif NN cord-325328-3l3jznkj 40 69 found find VBN cord-325328-3l3jznkj 40 70 at at IN cord-325328-3l3jznkj 40 71 the the DT cord-325328-3l3jznkj 40 72 3 3 CD cord-325328-3l3jznkj 40 73 0 0 CD cord-325328-3l3jznkj 40 74 end end NN cord-325328-3l3jznkj 40 75 of of IN cord-325328-3l3jznkj 40 76 the the DT cord-325328-3l3jznkj 40 77 genome genome NN cord-325328-3l3jznkj 40 78 of of IN cord-325328-3l3jznkj 40 79 SARS SARS NNP cord-325328-3l3jznkj 40 80 ( ( -LRB- cord-325328-3l3jznkj 40 81 severe severe JJ cord-325328-3l3jznkj 40 82 acute acute JJ cord-325328-3l3jznkj 40 83 respiratory respiratory JJ cord-325328-3l3jznkj 40 84 syndrome syndrome NN cord-325328-3l3jznkj 40 85 ) ) -RRB- cord-325328-3l3jznkj 40 86 virus virus NN cord-325328-3l3jznkj 40 87 and and CC cord-325328-3l3jznkj 40 88 other other JJ cord-325328-3l3jznkj 40 89 coronaviruses coronaviruse NNS cord-325328-3l3jznkj 40 90 [ [ -LRB- cord-325328-3l3jznkj 40 91 21 21 CD cord-325328-3l3jznkj 40 92 ] ] -RRB- cord-325328-3l3jznkj 40 93 ; ; : cord-325328-3l3jznkj 40 94 the the DT cord-325328-3l3jznkj 40 95 core core NN cord-325328-3l3jznkj 40 96 encapsidation encapsidation NN cord-325328-3l3jznkj 40 97 signal signal NN cord-325328-3l3jznkj 40 98 of of IN cord-325328-3l3jznkj 40 99 MMLV MMLV NNP cord-325328-3l3jznkj 40 100 [ [ -LRB- cord-325328-3l3jznkj 40 101 2 2 CD cord-325328-3l3jznkj 40 102 ] ] -RRB- cord-325328-3l3jznkj 40 103 ; ; : cord-325328-3l3jznkj 40 104 and and CC cord-325328-3l3jznkj 40 105 complexes complex NNS cord-325328-3l3jznkj 40 106 between between IN cord-325328-3l3jznkj 40 107 a a DT cord-325328-3l3jznkj 40 108 high high JJ cord-325328-3l3jznkj 40 109 - - HYPH cord-325328-3l3jznkj 40 110 affinity affinity NN cord-325328-3l3jznkj 40 111 RNA RNA NNP cord-325328-3l3jznkj 40 112 aptamer aptamer NN cord-325328-3l3jznkj 40 113 and and CC cord-325328-3l3jznkj 40 114 the the DT cord-325328-3l3jznkj 40 115 NF NF NNP cord-325328-3l3jznkj 40 116 - - HYPH cord-325328-3l3jznkj 40 117 kB kB NNP cord-325328-3l3jznkj 40 118 p50 p50 NN cord-325328-3l3jznkj 40 119 homodimer homodimer NN cord-325328-3l3jznkj 40 120 [ [ -LRB- cord-325328-3l3jznkj 40 121 22 22 CD cord-325328-3l3jznkj 40 122 ] ] -RRB- cord-325328-3l3jznkj 40 123 , , , cord-325328-3l3jznkj 40 124 and and CC cord-325328-3l3jznkj 40 125 between between IN cord-325328-3l3jznkj 40 126 the the DT cord-325328-3l3jznkj 40 127 archaeal archaeal JJ cord-325328-3l3jznkj 40 128 RNAbinding rnabinding NN cord-325328-3l3jznkj 40 129 protein protein NN cord-325328-3l3jznkj 40 130 L7Ae L7Ae NNP cord-325328-3l3jznkj 40 131 and and CC cord-325328-3l3jznkj 40 132 an an DT cord-325328-3l3jznkj 40 133 RNA RNA NNP cord-325328-3l3jznkj 40 134 K k NN cord-325328-3l3jznkj 40 135 - - HYPH cord-325328-3l3jznkj 40 136 turn turn NN cord-325328-3l3jznkj 40 137 derived derive VBN cord-325328-3l3jznkj 40 138 from from IN cord-325328-3l3jznkj 40 139 a a DT cord-325328-3l3jznkj 40 140 H H NNP cord-325328-3l3jznkj 40 141 / / SYM cord-325328-3l3jznkj 40 142 ACA ACA NNP cord-325328-3l3jznkj 40 143 small small JJ cord-325328-3l3jznkj 40 144 RNA RNA NNP cord-325328-3l3jznkj 40 145 [ [ -LRB- cord-325328-3l3jznkj 40 146 23 23 CD cord-325328-3l3jznkj 40 147 ] ] -RRB- cord-325328-3l3jznkj 40 148 . . . cord-325328-3l3jznkj 41 1 In in IN cord-325328-3l3jznkj 41 2 addition addition NN cord-325328-3l3jznkj 41 3 , , , cord-325328-3l3jznkj 41 4 a a DT cord-325328-3l3jznkj 41 5 series series NN cord-325328-3l3jznkj 41 6 of of IN cord-325328-3l3jznkj 41 7 crystal crystal NN cord-325328-3l3jznkj 41 8 structures structure NNS cord-325328-3l3jznkj 41 9 of of IN cord-325328-3l3jznkj 41 10 the the DT cord-325328-3l3jznkj 41 11 hepatitis hepatitis NN cord-325328-3l3jznkj 41 12 virus virus NN cord-325328-3l3jznkj 41 13 ribozyme ribozyme NNP cord-325328-3l3jznkj 41 14 in in IN cord-325328-3l3jznkj 41 15 its -PRON- PRP$ cord-325328-3l3jznkj 41 16 precleaved precleaved JJ cord-325328-3l3jznkj 41 17 state state NN cord-325328-3l3jznkj 41 18 [ [ -LRB- cord-325328-3l3jznkj 41 19 24 24 CD cord-325328-3l3jznkj 41 20 ] ] -RRB- cord-325328-3l3jznkj 41 21 showed show VBD cord-325328-3l3jznkj 41 22 that that IN cord-325328-3l3jznkj 41 23 significant significant JJ cord-325328-3l3jznkj 41 24 conformational conformational JJ cord-325328-3l3jznkj 41 25 changes change NNS cord-325328-3l3jznkj 41 26 take take VBP cord-325328-3l3jznkj 41 27 place place NN cord-325328-3l3jznkj 41 28 and and CC cord-325328-3l3jznkj 41 29 a a DT cord-325328-3l3jznkj 41 30 metal metal NN cord-325328-3l3jznkj 41 31 ion ion NN cord-325328-3l3jznkj 41 32 is be VBZ cord-325328-3l3jznkj 41 33 lost lose VBN cord-325328-3l3jznkj 41 34 in in IN cord-325328-3l3jznkj 41 35 comparison comparison NN cord-325328-3l3jznkj 41 36 to to IN cord-325328-3l3jznkj 41 37 the the DT cord-325328-3l3jznkj 41 38 product product NN cord-325328-3l3jznkj 41 39 form form NN cord-325328-3l3jznkj 41 40 of of IN cord-325328-3l3jznkj 41 41 the the DT cord-325328-3l3jznkj 41 42 ribozyme ribozyme NNS cord-325328-3l3jznkj 41 43 [ [ -LRB- cord-325328-3l3jznkj 41 44 25 25 CD cord-325328-3l3jznkj 41 45 ] ] -RRB- cord-325328-3l3jznkj 41 46 . . . cord-325328-3l3jznkj 42 1 Finally finally RB cord-325328-3l3jznkj 42 2 , , , cord-325328-3l3jznkj 42 3 structures structure NNS cord-325328-3l3jznkj 42 4 of of IN cord-325328-3l3jznkj 42 5 a a DT cord-325328-3l3jznkj 42 6 high high JJ cord-325328-3l3jznkj 42 7 - - HYPH cord-325328-3l3jznkj 42 8 salt salt NN cord-325328-3l3jznkj 42 9 left leave VBN cord-325328-3l3jznkj 42 10 - - HYPH cord-325328-3l3jznkj 42 11 handed handed JJ cord-325328-3l3jznkj 42 12 RNA RNA NNP cord-325328-3l3jznkj 42 13 duplex duplex NN cord-325328-3l3jznkj 42 14 [ [ -LRB- cord-325328-3l3jznkj 42 15 26 26 CD cord-325328-3l3jznkj 42 16 ] ] -RRB- cord-325328-3l3jznkj 42 17 and and CC cord-325328-3l3jznkj 42 18 a a DT cord-325328-3l3jznkj 42 19 mirror mirror NN cord-325328-3l3jznkj 42 20 image image NN cord-325328-3l3jznkj 42 21 ( ( -LRB- cord-325328-3l3jznkj 42 22 or or CC cord-325328-3l3jznkj 42 23 L l NN cord-325328-3l3jznkj 42 24 - - HYPH cord-325328-3l3jznkj 42 25 configuration configuration NN cord-325328-3l3jznkj 42 26 ) ) -RRB- cord-325328-3l3jznkj 42 27 [ [ -LRB- cord-325328-3l3jznkj 42 28 27 27 CD cord-325328-3l3jznkj 42 29 ] ] -RRB- cord-325328-3l3jznkj 42 30 RNA RNA NNP cord-325328-3l3jznkj 42 31 duplex duplex NN cord-325328-3l3jznkj 42 32 show show NN cord-325328-3l3jznkj 42 33 variations variation NNS cord-325328-3l3jznkj 42 34 on on IN cord-325328-3l3jznkj 42 35 the the DT cord-325328-3l3jznkj 42 36 canonical canonical JJ cord-325328-3l3jznkj 42 37 ' ' `` cord-325328-3l3jznkj 42 38 standard standard NN cord-325328-3l3jznkj 42 39 ' ' '' cord-325328-3l3jznkj 42 40 RNA RNA NNP cord-325328-3l3jznkj 42 41 double double JJ cord-325328-3l3jznkj 42 42 helix helix NN cord-325328-3l3jznkj 42 43 . . . cord-325328-3l3jznkj 43 1 These these DT cord-325328-3l3jznkj 43 2 structures structure NNS cord-325328-3l3jznkj 43 3 demonstrate demonstrate VBP cord-325328-3l3jznkj 43 4 not not RB cord-325328-3l3jznkj 43 5 only only RB cord-325328-3l3jznkj 43 6 the the DT cord-325328-3l3jznkj 43 7 prevalence prevalence NN cord-325328-3l3jznkj 43 8 of of IN cord-325328-3l3jznkj 43 9 well well RB cord-325328-3l3jznkj 43 10 - - HYPH cord-325328-3l3jznkj 43 11 known know VBN cord-325328-3l3jznkj 43 12 RNA RNA NNP cord-325328-3l3jznkj 43 13 structural structural JJ cord-325328-3l3jznkj 43 14 motifs motif NNS cord-325328-3l3jznkj 43 15 , , , cord-325328-3l3jznkj 43 16 but but CC cord-325328-3l3jznkj 43 17 also also RB cord-325328-3l3jznkj 43 18 the the DT cord-325328-3l3jznkj 43 19 presence presence NN cord-325328-3l3jznkj 43 20 of of IN cord-325328-3l3jznkj 43 21 numerous numerous JJ cord-325328-3l3jznkj 43 22 novel novel JJ cord-325328-3l3jznkj 43 23 structural structural JJ cord-325328-3l3jznkj 43 24 elements element NNS cord-325328-3l3jznkj 43 25 that that WDT cord-325328-3l3jznkj 43 26 potentially potentially RB cord-325328-3l3jznkj 43 27 may may MD cord-325328-3l3jznkj 43 28 serve serve VB cord-325328-3l3jznkj 43 29 as as IN cord-325328-3l3jznkj 43 30 common common JJ cord-325328-3l3jznkj 43 31 modules module NNS cord-325328-3l3jznkj 43 32 in in IN cord-325328-3l3jznkj 43 33 biological biological JJ cord-325328-3l3jznkj 43 34 RNA RNA NNP cord-325328-3l3jznkj 43 35 . . . cord-325328-3l3jznkj 44 1 Conversely conversely RB cord-325328-3l3jznkj 44 2 , , , cord-325328-3l3jznkj 44 3 the the DT cord-325328-3l3jznkj 44 4 structure structure NN cord-325328-3l3jznkj 44 5 of of IN cord-325328-3l3jznkj 44 6 an an DT cord-325328-3l3jznkj 44 7 alternative alternative JJ cord-325328-3l3jznkj 44 8 tRNA trna NN cord-325328-3l3jznkj 44 9 conformation conformation NN cord-325328-3l3jznkj 44 10 , , , cord-325328-3l3jznkj 44 11 designated designate VBN cord-325328-3l3jznkj 44 12 as as IN cord-325328-3l3jznkj 44 13 lambda lambda NN cord-325328-3l3jznkj 44 14 form form NN cord-325328-3l3jznkj 44 15 , , , cord-325328-3l3jznkj 44 16 has have VBZ cord-325328-3l3jznkj 44 17 been be VBN cord-325328-3l3jznkj 44 18 found find VBN cord-325328-3l3jznkj 44 19 in in IN cord-325328-3l3jznkj 44 20 complex complex NN cord-325328-3l3jznkj 44 21 with with IN cord-325328-3l3jznkj 44 22 the the DT cord-325328-3l3jznkj 44 23 tRNA tRNA NNP cord-325328-3l3jznkj 44 24 modification modification NN cord-325328-3l3jznkj 44 25 enzyme enzyme NN cord-325328-3l3jznkj 44 26 archaeosine archaeosine NNP cord-325328-3l3jznkj 44 27 tRNA tRNA NNP cord-325328-3l3jznkj 44 28 - - HYPH cord-325328-3l3jznkj 44 29 guanine guanine NN cord-325328-3l3jznkj 44 30 transglycosylase transglycosylase NN cord-325328-3l3jznkj 44 31 [ [ -LRB- cord-325328-3l3jznkj 44 32 28 28 CD cord-325328-3l3jznkj 44 33 , , , cord-325328-3l3jznkj 44 34 29 29 CD cord-325328-3l3jznkj 44 35 ] ] -RRB- cord-325328-3l3jznkj 44 36 . . . cord-325328-3l3jznkj 45 1 In in IN cord-325328-3l3jznkj 45 2 this this DT cord-325328-3l3jznkj 45 3 complex complex NN cord-325328-3l3jznkj 45 4 , , , cord-325328-3l3jznkj 45 5 the the DT cord-325328-3l3jznkj 45 6 tertiary tertiary JJ cord-325328-3l3jznkj 45 7 interactions interaction NNS cord-325328-3l3jznkj 45 8 between between IN cord-325328-3l3jznkj 45 9 the the DT cord-325328-3l3jznkj 45 10 D d NN cord-325328-3l3jznkj 45 11 - - HYPH cord-325328-3l3jznkj 45 12 loop loop NN cord-325328-3l3jznkj 45 13 and and CC cord-325328-3l3jznkj 45 14 Tloop Tloop NNP cord-325328-3l3jznkj 45 15 are be VBP cord-325328-3l3jznkj 45 16 disrupted disrupt VBN cord-325328-3l3jznkj 45 17 , , , cord-325328-3l3jznkj 45 18 leading lead VBG cord-325328-3l3jznkj 45 19 to to IN cord-325328-3l3jznkj 45 20 an an DT cord-325328-3l3jznkj 45 21 alternative alternative JJ cord-325328-3l3jznkj 45 22 base base NN cord-325328-3l3jznkj 45 23 pairing pairing NN cord-325328-3l3jznkj 45 24 pattern pattern NN cord-325328-3l3jznkj 45 25 . . . cord-325328-3l3jznkj 46 1 This this DT cord-325328-3l3jznkj 46 2 suggests suggest VBZ cord-325328-3l3jznkj 46 3 that that IN cord-325328-3l3jznkj 46 4 RNA RNA NNP cord-325328-3l3jznkj 46 5 structure structure NN cord-325328-3l3jznkj 46 6 in in IN cord-325328-3l3jznkj 46 7 general general JJ cord-325328-3l3jznkj 46 8 , , , cord-325328-3l3jznkj 46 9 and and CC cord-325328-3l3jznkj 46 10 motif motif NN cord-325328-3l3jznkj 46 11 structure structure NN cord-325328-3l3jznkj 46 12 specifically specifically RB cord-325328-3l3jznkj 46 13 , , , cord-325328-3l3jznkj 46 14 are be VBP cord-325328-3l3jznkj 46 15 subject subject JJ cord-325328-3l3jznkj 46 16 to to IN cord-325328-3l3jznkj 46 17 change change NN cord-325328-3l3jznkj 46 18 through through IN cord-325328-3l3jznkj 46 19 interaction interaction NN cord-325328-3l3jznkj 46 20 with with IN cord-325328-3l3jznkj 46 21 environmental environmental JJ cord-325328-3l3jznkj 46 22 agents agent NNS cord-325328-3l3jznkj 46 23 such such JJ cord-325328-3l3jznkj 46 24 as as IN cord-325328-3l3jznkj 46 25 proteins protein NNS cord-325328-3l3jznkj 46 26 , , , cord-325328-3l3jznkj 46 27 other other JJ cord-325328-3l3jznkj 46 28 RNAs rna NNS cord-325328-3l3jznkj 46 29 , , , cord-325328-3l3jznkj 46 30 metals metal NNS cord-325328-3l3jznkj 46 31 or or CC cord-325328-3l3jznkj 46 32 other other JJ cord-325328-3l3jznkj 46 33 ligands ligand NNS cord-325328-3l3jznkj 46 34 . . . cord-325328-3l3jznkj 47 1 Number number NN cord-325328-3l3jznkj 47 2 of of IN cord-325328-3l3jznkj 47 3 RNA RNA NNP cord-325328-3l3jznkj 47 4 structures structure NNS cord-325328-3l3jznkj 47 5 deposited deposit VBN cord-325328-3l3jznkj 47 6 in in IN cord-325328-3l3jznkj 47 7 the the DT cord-325328-3l3jznkj 47 8 NDB ndb NN cord-325328-3l3jznkj 47 9 ( ( -LRB- cord-325328-3l3jznkj 47 10 http://ndbserver.rutgers.edu/ http://ndbserver.rutgers.edu/ ADD cord-325328-3l3jznkj 47 11 ) ) -RRB- cord-325328-3l3jznkj 47 12 ( ( -LRB- cord-325328-3l3jznkj 47 13 dark dark JJ cord-325328-3l3jznkj 47 14 red red NNP cord-325328-3l3jznkj 47 15 ) ) -RRB- cord-325328-3l3jznkj 47 16 and and CC cord-325328-3l3jznkj 47 17 the the DT cord-325328-3l3jznkj 47 18 average average JJ cord-325328-3l3jznkj 47 19 number number NN cord-325328-3l3jznkj 47 20 of of IN cord-325328-3l3jznkj 47 21 nucleotides nucleotide NNS cord-325328-3l3jznkj 47 22 per per IN cord-325328-3l3jznkj 47 23 structure structure NN cord-325328-3l3jznkj 47 24 ( ( -LRB- cord-325328-3l3jznkj 47 25 yellow yellow JJ cord-325328-3l3jznkj 47 26 ) ) -RRB- cord-325328-3l3jznkj 47 27 given give VBN cord-325328-3l3jznkj 47 28 by by IN cord-325328-3l3jznkj 47 29 year year NN cord-325328-3l3jznkj 47 30 . . . cord-325328-3l3jznkj 48 1 Although although IN cord-325328-3l3jznkj 48 2 the the DT cord-325328-3l3jznkj 48 3 number number NN cord-325328-3l3jznkj 48 4 of of IN cord-325328-3l3jznkj 48 5 structure structure NN cord-325328-3l3jznkj 48 6 determinations determination NNS cord-325328-3l3jznkj 48 7 has have VBZ cord-325328-3l3jznkj 48 8 grown grow VBN cord-325328-3l3jznkj 48 9 only only RB cord-325328-3l3jznkj 48 10 slowly slowly RB cord-325328-3l3jznkj 48 11 , , , cord-325328-3l3jznkj 48 12 the the DT cord-325328-3l3jznkj 48 13 average average JJ cord-325328-3l3jznkj 48 14 structure structure NN cord-325328-3l3jznkj 48 15 size size NN cord-325328-3l3jznkj 48 16 has have VBZ cord-325328-3l3jznkj 48 17 dramatically dramatically RB cord-325328-3l3jznkj 48 18 increased increase VBN cord-325328-3l3jznkj 48 19 since since IN cord-325328-3l3jznkj 48 20 2000 2000 CD cord-325328-3l3jznkj 48 21 . . . cord-325328-3l3jznkj 49 1 The the DT cord-325328-3l3jznkj 49 2 availability availability NN cord-325328-3l3jznkj 49 3 of of IN cord-325328-3l3jznkj 49 4 numerous numerous JJ cord-325328-3l3jznkj 49 5 diverse diverse JJ cord-325328-3l3jznkj 49 6 , , , cord-325328-3l3jznkj 49 7 large large JJ cord-325328-3l3jznkj 49 8 RNA RNA NNP cord-325328-3l3jznkj 49 9 structures structure NNS cord-325328-3l3jznkj 49 10 has have VBZ cord-325328-3l3jznkj 49 11 made make VBN cord-325328-3l3jznkj 49 12 possible possible JJ cord-325328-3l3jznkj 49 13 the the DT cord-325328-3l3jznkj 49 14 identification identification NN cord-325328-3l3jznkj 49 15 and and CC cord-325328-3l3jznkj 49 16 classification classification NN cord-325328-3l3jznkj 49 17 of of IN cord-325328-3l3jznkj 49 18 an an DT cord-325328-3l3jznkj 49 19 increasing increase VBG cord-325328-3l3jznkj 49 20 number number NN cord-325328-3l3jznkj 49 21 of of IN cord-325328-3l3jznkj 49 22 RNA RNA NNP cord-325328-3l3jznkj 49 23 secondary secondary JJ cord-325328-3l3jznkj 49 24 and and CC cord-325328-3l3jznkj 49 25 tertiary tertiary JJ cord-325328-3l3jznkj 49 26 structure structure NN cord-325328-3l3jznkj 49 27 motifs motif NNS cord-325328-3l3jznkj 49 28 . . . cord-325328-3l3jznkj 50 1 Both both DT cord-325328-3l3jznkj 50 2 manual manual JJ cord-325328-3l3jznkj 50 3 and and CC cord-325328-3l3jznkj 50 4 automated automated JJ cord-325328-3l3jznkj 50 5 classification classification NN cord-325328-3l3jznkj 50 6 procedures procedure NNS cord-325328-3l3jznkj 50 7 are be VBP cord-325328-3l3jznkj 50 8 being be VBG cord-325328-3l3jznkj 50 9 used use VBN cord-325328-3l3jznkj 50 10 to to TO cord-325328-3l3jznkj 50 11 identify identify VB cord-325328-3l3jznkj 50 12 and and CC cord-325328-3l3jznkj 50 13 characterize characterize VB cord-325328-3l3jznkj 50 14 motifs motif NNS cord-325328-3l3jznkj 50 15 [ [ -LRB- cord-325328-3l3jznkj 50 16 4 4 CD cord-325328-3l3jznkj 50 17 ] ] -RRB- cord-325328-3l3jznkj 50 18 . . . cord-325328-3l3jznkj 51 1 A a DT cord-325328-3l3jznkj 51 2 database database NN cord-325328-3l3jznkj 51 3 of of IN cord-325328-3l3jznkj 51 4 non non JJ cord-325328-3l3jznkj 51 5 - - JJ cord-325328-3l3jznkj 51 6 canonical canonical JJ cord-325328-3l3jznkj 51 7 base base NN cord-325328-3l3jznkj 51 8 pairs pair NNS cord-325328-3l3jznkj 51 9 in in IN cord-325328-3l3jznkj 51 10 RNA RNA NNP cord-325328-3l3jznkj 51 11 structures structure NNS cord-325328-3l3jznkj 51 12 [ [ -LRB- cord-325328-3l3jznkj 51 13 30 30 CD cord-325328-3l3jznkj 51 14 ] ] -RRB- cord-325328-3l3jznkj 51 15 , , , cord-325328-3l3jznkj 51 16 coupled couple VBN cord-325328-3l3jznkj 51 17 with with IN cord-325328-3l3jznkj 51 18 tools tool NNS cord-325328-3l3jznkj 51 19 for for IN cord-325328-3l3jznkj 51 20 the the DT cord-325328-3l3jznkj 51 21 automatic automatic JJ cord-325328-3l3jznkj 51 22 identification identification NN cord-325328-3l3jznkj 51 23 and and CC cord-325328-3l3jznkj 51 24 classification classification NN cord-325328-3l3jznkj 51 25 of of IN cord-325328-3l3jznkj 51 26 RNA RNA NNP cord-325328-3l3jznkj 51 27 base base NN cord-325328-3l3jznkj 51 28 pairs pair NNS cord-325328-3l3jznkj 51 29 [ [ -LRB- cord-325328-3l3jznkj 51 30 31 31 CD cord-325328-3l3jznkj 51 31 ] ] -RRB- cord-325328-3l3jznkj 51 32 , , , cord-325328-3l3jznkj 51 33 provides provide VBZ cord-325328-3l3jznkj 51 34 an an DT cord-325328-3l3jznkj 51 35 initial initial JJ cord-325328-3l3jznkj 51 36 description description NN cord-325328-3l3jznkj 51 37 of of IN cord-325328-3l3jznkj 51 38 RNA RNA NNP cord-325328-3l3jznkj 51 39 secondary secondary JJ cord-325328-3l3jznkj 51 40 structure structure NN cord-325328-3l3jznkj 51 41 . . . cord-325328-3l3jznkj 52 1 This this DT cord-325328-3l3jznkj 52 2 description description NN cord-325328-3l3jznkj 52 3 can can MD cord-325328-3l3jznkj 52 4 be be VB cord-325328-3l3jznkj 52 5 coupled couple VBN cord-325328-3l3jznkj 52 6 with with IN cord-325328-3l3jznkj 52 7 automated automated JJ cord-325328-3l3jznkj 52 8 motif motif NN cord-325328-3l3jznkj 52 9 searches search NNS cord-325328-3l3jznkj 52 10 [ [ -LRB- cord-325328-3l3jznkj 52 11 32 32 CD cord-325328-3l3jznkj 52 12 ] ] -RRB- cord-325328-3l3jznkj 52 13 [ [ -LRB- cord-325328-3l3jznkj 52 14 33 33 CD cord-325328-3l3jznkj 52 15 ] ] -RRB- cord-325328-3l3jznkj 52 16 [ [ -LRB- cord-325328-3l3jznkj 52 17 34 34 CD cord-325328-3l3jznkj 52 18 ] ] -RRB- cord-325328-3l3jznkj 52 19 , , , cord-325328-3l3jznkj 52 20 identifying identify VBG cord-325328-3l3jznkj 52 21 both both DT cord-325328-3l3jznkj 52 22 previously previously RB cord-325328-3l3jznkj 52 23 known know VBN cord-325328-3l3jznkj 52 24 and and CC cord-325328-3l3jznkj 52 25 new new JJ cord-325328-3l3jznkj 52 26 RNA RNA NNP cord-325328-3l3jznkj 52 27 motifs motif NNS cord-325328-3l3jznkj 52 28 . . . cord-325328-3l3jznkj 53 1 The the DT cord-325328-3l3jznkj 53 2 SCOR SCOR NNP cord-325328-3l3jznkj 53 3 ( ( -LRB- cord-325328-3l3jznkj 53 4 Structural Structural NNP cord-325328-3l3jznkj 53 5 Classification Classification NNP cord-325328-3l3jznkj 53 6 of of IN cord-325328-3l3jznkj 53 7 RNA RNA NNP cord-325328-3l3jznkj 53 8 ) ) -RRB- cord-325328-3l3jznkj 53 9 database database NN cord-325328-3l3jznkj 53 10 is be VBZ cord-325328-3l3jznkj 53 11 a a DT cord-325328-3l3jznkj 53 12 comprehensive comprehensive JJ cord-325328-3l3jznkj 53 13 , , , cord-325328-3l3jznkj 53 14 manually manually RB cord-325328-3l3jznkj 53 15 curated curate VBN cord-325328-3l3jznkj 53 16 resource resource NN cord-325328-3l3jznkj 53 17 of of IN cord-325328-3l3jznkj 53 18 RNA RNA NNP cord-325328-3l3jznkj 53 19 structural structural JJ cord-325328-3l3jznkj 53 20 motifs motif NNS cord-325328-3l3jznkj 53 21 that that WDT cord-325328-3l3jznkj 53 22 utilizes utilize VBZ cord-325328-3l3jznkj 53 23 automated automate VBN cord-325328-3l3jznkj 53 24 tools tool NNS cord-325328-3l3jznkj 53 25 and and CC cord-325328-3l3jznkj 53 26 literature literature NN cord-325328-3l3jznkj 53 27 descriptions description NNS cord-325328-3l3jznkj 53 28 to to TO cord-325328-3l3jznkj 53 29 assist assist VB cord-325328-3l3jznkj 53 30 in in IN cord-325328-3l3jznkj 53 31 the the DT cord-325328-3l3jznkj 53 32 classification classification NN cord-325328-3l3jznkj 53 33 of of IN cord-325328-3l3jznkj 53 34 RNA RNA NNP cord-325328-3l3jznkj 53 35 secondary secondary JJ cord-325328-3l3jznkj 53 36 and and CC cord-325328-3l3jznkj 53 37 tertiary tertiary JJ cord-325328-3l3jznkj 53 38 structure structure NN cord-325328-3l3jznkj 53 39 motifs motif NNS cord-325328-3l3jznkj 53 40 [ [ -LRB- cord-325328-3l3jznkj 53 41 35 35 CD cord-325328-3l3jznkj 53 42 , , , cord-325328-3l3jznkj 53 43 36 36 CD cord-325328-3l3jznkj 53 44 ] ] -RRB- cord-325328-3l3jznkj 53 45 . . . cord-325328-3l3jznkj 54 1 Characterization characterization NN cord-325328-3l3jznkj 54 2 of of IN cord-325328-3l3jznkj 54 3 these these DT cord-325328-3l3jznkj 54 4 motifs motif NNS cord-325328-3l3jznkj 54 5 or or CC cord-325328-3l3jznkj 54 6 RNA RNA NNP cord-325328-3l3jznkj 54 7 building building NN cord-325328-3l3jznkj 54 8 blocks block NNS cord-325328-3l3jznkj 54 9 in in IN cord-325328-3l3jznkj 54 10 turn turn NN cord-325328-3l3jznkj 54 11 is be VBZ cord-325328-3l3jznkj 54 12 enabling enable VBG cord-325328-3l3jznkj 54 13 RNA RNA NNP cord-325328-3l3jznkj 54 14 design design NN cord-325328-3l3jznkj 54 15 [ [ -LRB- cord-325328-3l3jznkj 54 16 37 37 CD cord-325328-3l3jznkj 54 17 , , , cord-325328-3l3jznkj 54 18 38 38 CD cord-325328-3l3jznkj 54 19 ] ] -RRB- cord-325328-3l3jznkj 54 20 , , , cord-325328-3l3jznkj 54 21 RNA RNA NNP cord-325328-3l3jznkj 54 22 structure structure NN cord-325328-3l3jznkj 54 23 prediction prediction NN cord-325328-3l3jznkj 54 24 , , , cord-325328-3l3jznkj 54 25 RNA RNA NNP cord-325328-3l3jznkj 54 26 modeling modeling NN cord-325328-3l3jznkj 54 27 and and CC cord-325328-3l3jznkj 54 28 RNA RNA NNP cord-325328-3l3jznkj 54 29 gene gene NN cord-325328-3l3jznkj 54 30 finding find VBG cord-325328-3l3jznkj 54 31 [ [ -LRB- cord-325328-3l3jznkj 54 32 39 39 CD cord-325328-3l3jznkj 54 33 ] ] -RRB- cord-325328-3l3jznkj 54 34 . . . cord-325328-3l3jznkj 55 1 Recently recently RB cord-325328-3l3jznkj 55 2 determined determine VBN cord-325328-3l3jznkj 55 3 crystal crystal NN cord-325328-3l3jznkj 55 4 structures structure NNS cord-325328-3l3jznkj 55 5 of of IN cord-325328-3l3jznkj 55 6 RNA RNA NNP cord-325328-3l3jznkj 55 7 and and CC cord-325328-3l3jznkj 55 8 RNA RNA NNP cord-325328-3l3jznkj 55 9 - - HYPH cord-325328-3l3jznkj 55 10 protein protein NN cord-325328-3l3jznkj 55 11 complexes complex NNS cord-325328-3l3jznkj 55 12 ( ( -LRB- cord-325328-3l3jznkj 55 13 in in IN cord-325328-3l3jznkj 55 14 addition addition NN cord-325328-3l3jznkj 55 15 to to IN cord-325328-3l3jznkj 55 16 rRNA rrna JJ cord-325328-3l3jznkj 55 17 structures structure NNS cord-325328-3l3jznkj 55 18 ) ) -RRB- cord-325328-3l3jznkj 55 19 are be VBP cord-325328-3l3jznkj 55 20 revealing reveal VBG cord-325328-3l3jznkj 55 21 many many JJ cord-325328-3l3jznkj 55 22 new new JJ cord-325328-3l3jznkj 55 23 structural structural JJ cord-325328-3l3jznkj 55 24 elements element NNS cord-325328-3l3jznkj 55 25 , , , cord-325328-3l3jznkj 55 26 in in IN cord-325328-3l3jznkj 55 27 addition addition NN cord-325328-3l3jznkj 55 28 to to IN cord-325328-3l3jznkj 55 29 previously previously RB cord-325328-3l3jznkj 55 30 characterized characterize VBN cord-325328-3l3jznkj 55 31 motifs motif NNS cord-325328-3l3jznkj 55 32 ( ( -LRB- cord-325328-3l3jznkj 55 33 as as IN cord-325328-3l3jznkj 55 34 summarized summarize VBN cord-325328-3l3jznkj 55 35 in in IN cord-325328-3l3jznkj 55 36 Table Table NNP cord-325328-3l3jznkj 55 37 1 1 CD cord-325328-3l3jznkj 55 38 ) ) -RRB- cord-325328-3l3jznkj 55 39 . . . cord-325328-3l3jznkj 56 1 As as IN cord-325328-3l3jznkj 56 2 additional additional JJ cord-325328-3l3jznkj 56 3 RNA RNA NNP cord-325328-3l3jznkj 56 4 structures structure NNS cord-325328-3l3jznkj 56 5 are be VBP cord-325328-3l3jznkj 56 6 determined determine VBN cord-325328-3l3jznkj 56 7 , , , cord-325328-3l3jznkj 56 8 304 304 CD cord-325328-3l3jznkj 56 9 Sequences Sequences NNPS cord-325328-3l3jznkj 56 10 and and CC cord-325328-3l3jznkj 56 11 topology topology VB cord-325328-3l3jznkj 56 12 the the DT cord-325328-3l3jznkj 56 13 occurrence occurrence NN cord-325328-3l3jznkj 56 14 of of IN cord-325328-3l3jznkj 56 15 these these DT cord-325328-3l3jznkj 56 16 elements element NNS cord-325328-3l3jznkj 56 17 may may MD cord-325328-3l3jznkj 56 18 indicate indicate VB cord-325328-3l3jznkj 56 19 that that IN cord-325328-3l3jznkj 56 20 they -PRON- PRP cord-325328-3l3jznkj 56 21 are be VBP cord-325328-3l3jznkj 56 22 common common JJ cord-325328-3l3jznkj 56 23 structural structural JJ cord-325328-3l3jznkj 56 24 motifs motif NNS cord-325328-3l3jznkj 56 25 , , , cord-325328-3l3jznkj 56 26 and and CC cord-325328-3l3jznkj 56 27 thus thus RB cord-325328-3l3jznkj 56 28 enable enable VB cord-325328-3l3jznkj 56 29 their -PRON- PRP$ cord-325328-3l3jznkj 56 30 characterization characterization NN cord-325328-3l3jznkj 56 31 by by IN cord-325328-3l3jznkj 56 32 sequence sequence NN cord-325328-3l3jznkj 56 33 , , , cord-325328-3l3jznkj 56 34 structure structure NN cord-325328-3l3jznkj 56 35 and and CC cord-325328-3l3jznkj 56 36 function function NN cord-325328-3l3jznkj 56 37 . . . cord-325328-3l3jznkj 57 1 Presented present VBN cord-325328-3l3jznkj 57 2 below below RB cord-325328-3l3jznkj 57 3 are be VBP cord-325328-3l3jznkj 57 4 examples example NNS cord-325328-3l3jznkj 57 5 of of IN cord-325328-3l3jznkj 57 6 recently recently RB cord-325328-3l3jznkj 57 7 determined determine VBN cord-325328-3l3jznkj 57 8 RNA RNA NNP cord-325328-3l3jznkj 57 9 structures structure NNS cord-325328-3l3jznkj 57 10 that that WDT cord-325328-3l3jznkj 57 11 have have VBP cord-325328-3l3jznkj 57 12 both both DT cord-325328-3l3jznkj 57 13 known know VBN cord-325328-3l3jznkj 57 14 RNA RNA NNP cord-325328-3l3jznkj 57 15 motifs motif NNS cord-325328-3l3jznkj 57 16 and and CC cord-325328-3l3jznkj 57 17 novel novel JJ cord-325328-3l3jznkj 57 18 structural structural JJ cord-325328-3l3jznkj 57 19 features feature NNS cord-325328-3l3jznkj 57 20 that that WDT cord-325328-3l3jznkj 57 21 may may MD cord-325328-3l3jznkj 57 22 correspond correspond VB cord-325328-3l3jznkj 57 23 to to IN cord-325328-3l3jznkj 57 24 new new JJ cord-325328-3l3jznkj 57 25 structural structural JJ cord-325328-3l3jznkj 57 26 motifs motif NNS cord-325328-3l3jznkj 57 27 . . . cord-325328-3l3jznkj 58 1 These these DT cord-325328-3l3jznkj 58 2 motifs motif NNS cord-325328-3l3jznkj 58 3 are be VBP cord-325328-3l3jznkj 58 4 likely likely JJ cord-325328-3l3jznkj 58 5 to to TO cord-325328-3l3jznkj 58 6 be be VB cord-325328-3l3jznkj 58 7 crucial crucial JJ cord-325328-3l3jznkj 58 8 to to IN cord-325328-3l3jznkj 58 9 both both DT cord-325328-3l3jznkj 58 10 biological biological JJ cord-325328-3l3jznkj 58 11 function function NN cord-325328-3l3jznkj 58 12 and and CC cord-325328-3l3jznkj 58 13 three three CD cord-325328-3l3jznkj 58 14 - - HYPH cord-325328-3l3jznkj 58 15 dimensional dimensional JJ cord-325328-3l3jznkj 58 16 structure structure NN cord-325328-3l3jznkj 58 17 . . . cord-325328-3l3jznkj 59 1 The the DT cord-325328-3l3jznkj 59 2 3 3 CD cord-325328-3l3jznkj 59 3 0 0 CD cord-325328-3l3jznkj 59 4 end end NN cord-325328-3l3jznkj 59 5 of of IN cord-325328-3l3jznkj 59 6 the the DT cord-325328-3l3jznkj 59 7 genome genome NN cord-325328-3l3jznkj 59 8 of of IN cord-325328-3l3jznkj 59 9 SARS SARS NNP cord-325328-3l3jznkj 59 10 virus virus NN cord-325328-3l3jznkj 59 11 and and CC cord-325328-3l3jznkj 59 12 related related JJ cord-325328-3l3jznkj 59 13 coronaviruses coronaviruse NNS cord-325328-3l3jznkj 59 14 and and CC cord-325328-3l3jznkj 59 15 astroviruses astroviruses NNP cord-325328-3l3jznkj 59 16 contains contain VBZ cord-325328-3l3jznkj 59 17 a a DT cord-325328-3l3jznkj 59 18 highly highly RB cord-325328-3l3jznkj 59 19 conserved conserve VBN cord-325328-3l3jznkj 59 20 sequence sequence NN cord-325328-3l3jznkj 59 21 called call VBN cord-325328-3l3jznkj 59 22 the the DT cord-325328-3l3jznkj 59 23 s2 s2 NNP cord-325328-3l3jznkj 59 24 m m NNP cord-325328-3l3jznkj 59 25 or or CC cord-325328-3l3jznkj 59 26 stem stem NN cord-325328-3l3jznkj 59 27 - - HYPH cord-325328-3l3jznkj 59 28 loop loop NN cord-325328-3l3jznkj 59 29 II II NNP cord-325328-3l3jznkj 59 30 element element NN cord-325328-3l3jznkj 59 31 . . . cord-325328-3l3jznkj 60 1 As as IN cord-325328-3l3jznkj 60 2 shown show VBN cord-325328-3l3jznkj 60 3 in in IN cord-325328-3l3jznkj 60 4 Table Table NNP cord-325328-3l3jznkj 60 5 1 1 CD cord-325328-3l3jznkj 60 6 , , , cord-325328-3l3jznkj 60 7 the the DT cord-325328-3l3jznkj 60 8 crystal crystal NN cord-325328-3l3jznkj 60 9 structure structure NN cord-325328-3l3jznkj 60 10 of of IN cord-325328-3l3jznkj 60 11 a a DT cord-325328-3l3jznkj 60 12 48-nucleotide 48-nucleotide CD cord-325328-3l3jznkj 60 13 RNA RNA NNP cord-325328-3l3jznkj 60 14 corresponding correspond VBG cord-325328-3l3jznkj 60 15 to to IN cord-325328-3l3jznkj 60 16 this this DT cord-325328-3l3jznkj 60 17 element element NN cord-325328-3l3jznkj 60 18 has have VBZ cord-325328-3l3jznkj 60 19 been be VBN cord-325328-3l3jznkj 60 20 solved solve VBN cord-325328-3l3jznkj 60 21 at at IN cord-325328-3l3jznkj 60 22 2.7 2.7 CD cord-325328-3l3jznkj 60 23 Å å NN cord-325328-3l3jznkj 60 24 resolution resolution NN cord-325328-3l3jznkj 60 25 [ [ -LRB- cord-325328-3l3jznkj 60 26 21 21 CD cord-325328-3l3jznkj 60 27 ] ] -RRB- cord-325328-3l3jznkj 60 28 . . . cord-325328-3l3jznkj 61 1 In in IN cord-325328-3l3jznkj 61 2 addition addition NN cord-325328-3l3jznkj 61 3 to to IN cord-325328-3l3jznkj 61 4 previously previously RB cord-325328-3l3jznkj 61 5 characterized characterize VBN cord-325328-3l3jznkj 61 6 RNA RNA NNP cord-325328-3l3jznkj 61 7 structural structural JJ cord-325328-3l3jznkj 61 8 motifs motif NNS cord-325328-3l3jznkj 61 9 , , , cord-325328-3l3jznkj 61 10 such such JJ cord-325328-3l3jznkj 61 11 as as IN cord-325328-3l3jznkj 61 12 a a DT cord-325328-3l3jznkj 61 13 GNRA GNRA NNP cord-325328-3l3jznkj 61 14 - - HYPH cord-325328-3l3jznkj 61 15 like like JJ cord-325328-3l3jznkj 61 16 pentaloop pentaloop NN cord-325328-3l3jznkj 61 17 and and CC cord-325328-3l3jznkj 61 18 a a DT cord-325328-3l3jznkj 61 19 dinucleotide dinucleotide NN cord-325328-3l3jznkj 61 20 platform platform NN cord-325328-3l3jznkj 61 21 base base NN cord-325328-3l3jznkj 61 22 triple triple JJ cord-325328-3l3jznkj 61 23 [ [ -LRB- cord-325328-3l3jznkj 61 24 36 36 CD cord-325328-3l3jznkj 61 25 ] ] -RRB- cord-325328-3l3jznkj 61 26 , , , cord-325328-3l3jznkj 61 27 novel novel JJ cord-325328-3l3jznkj 61 28 structural structural JJ cord-325328-3l3jznkj 61 29 features feature NNS cord-325328-3l3jznkj 61 30 were be VBD cord-325328-3l3jznkj 61 31 observed observe VBN cord-325328-3l3jznkj 61 32 . . . cord-325328-3l3jznkj 62 1 A a DT cord-325328-3l3jznkj 62 2 unique unique JJ cord-325328-3l3jznkj 62 3 base base NN cord-325328-3l3jznkj 62 4 quartet quartet NN cord-325328-3l3jznkj 62 5 is be VBZ cord-325328-3l3jznkj 62 6 formed form VBN cord-325328-3l3jznkj 62 7 between between IN cord-325328-3l3jznkj 62 8 Watson Watson NNP cord-325328-3l3jznkj 62 9 - - HYPH cord-325328-3l3jznkj 62 10 Crick Crick NNP cord-325328-3l3jznkj 62 11 GC GC NNP cord-325328-3l3jznkj 62 12 pairs pair NNS cord-325328-3l3jznkj 62 13 at at IN cord-325328-3l3jznkj 62 14 the the DT cord-325328-3l3jznkj 62 15 junction junction NN cord-325328-3l3jznkj 62 16 of of IN cord-325328-3l3jznkj 62 17 two two CD cord-325328-3l3jznkj 62 18 helices helix NNS cord-325328-3l3jznkj 62 19 , , , cord-325328-3l3jznkj 62 20 as as IN cord-325328-3l3jznkj 62 21 shown show VBN cord-325328-3l3jznkj 62 22 in in IN cord-325328-3l3jznkj 62 23 Figure figure NN cord-325328-3l3jznkj 62 24 2 2 CD cord-325328-3l3jznkj 62 25 . . . cord-325328-3l3jznkj 63 1 Another another DT cord-325328-3l3jznkj 63 2 novel novel JJ cord-325328-3l3jznkj 63 3 RNA RNA NNP cord-325328-3l3jznkj 63 4 structural structural JJ cord-325328-3l3jznkj 63 5 feature feature NN cord-325328-3l3jznkj 63 6 is be VBZ cord-325328-3l3jznkj 63 7 formed form VBN cord-325328-3l3jznkj 63 8 by by IN cord-325328-3l3jznkj 63 9 a a DT cord-325328-3l3jznkj 63 10 three three CD cord-325328-3l3jznkj 63 11 - - HYPH cord-325328-3l3jznkj 63 12 purine purine NN cord-325328-3l3jznkj 63 13 bulge bulge NN cord-325328-3l3jznkj 63 14 that that WDT cord-325328-3l3jznkj 63 15 excludes exclude VBZ cord-325328-3l3jznkj 63 16 an an DT cord-325328-3l3jznkj 63 17 adenosine adenosine NN cord-325328-3l3jznkj 63 18 from from IN cord-325328-3l3jznkj 63 19 the the DT cord-325328-3l3jznkj 63 20 central central JJ cord-325328-3l3jznkj 63 21 stack stack NN cord-325328-3l3jznkj 63 22 and and CC cord-325328-3l3jznkj 63 23 forms form VBZ cord-325328-3l3jznkj 63 24 tertiary tertiary JJ cord-325328-3l3jznkj 63 25 interactions interaction NNS cord-325328-3l3jznkj 63 26 with with IN cord-325328-3l3jznkj 63 27 residues residue NNS cord-325328-3l3jznkj 63 28 from from IN cord-325328-3l3jznkj 63 29 an an DT cord-325328-3l3jznkj 63 30 asymmetric asymmetric JJ cord-325328-3l3jznkj 63 31 internal internal JJ cord-325328-3l3jznkj 63 32 loop loop NN cord-325328-3l3jznkj 63 33 , , , cord-325328-3l3jznkj 63 34 forming form VBG cord-325328-3l3jznkj 63 35 a a DT cord-325328-3l3jznkj 63 36 ' ' `` cord-325328-3l3jznkj 63 37 tunnel tunnel NN cord-325328-3l3jznkj 63 38 ' ' '' cord-325328-3l3jznkj 63 39 that that WDT cord-325328-3l3jznkj 63 40 serves serve VBZ cord-325328-3l3jznkj 63 41 as as IN cord-325328-3l3jznkj 63 42 a a DT cord-325328-3l3jznkj 63 43 binding binding JJ cord-325328-3l3jznkj 63 44 site site NN cord-325328-3l3jznkj 63 45 for for IN cord-325328-3l3jznkj 63 46 two two CD cord-325328-3l3jznkj 63 47 magnesium magnesium NN cord-325328-3l3jznkj 63 48 ions ion NNS cord-325328-3l3jznkj 63 49 [ [ -LRB- cord-325328-3l3jznkj 63 50 21 21 CD cord-325328-3l3jznkj 63 51 ] ] -RRB- cord-325328-3l3jznkj 63 52 . . . cord-325328-3l3jznkj 64 1 The the DT cord-325328-3l3jznkj 64 2 interaction interaction NN cord-325328-3l3jznkj 64 3 between between IN cord-325328-3l3jznkj 64 4 two two CD cord-325328-3l3jznkj 64 5 hairpin hairpin JJ cord-325328-3l3jznkj 64 6 loops loop NNS cord-325328-3l3jznkj 64 7 in in IN cord-325328-3l3jznkj 64 8 the the DT cord-325328-3l3jznkj 64 9 guanineresponsive guanineresponsive JJ cord-325328-3l3jznkj 64 10 riboswitch riboswitch NN cord-325328-3l3jznkj 64 11 is be VBZ cord-325328-3l3jznkj 64 12 required require VBN cord-325328-3l3jznkj 64 13 for for IN cord-325328-3l3jznkj 64 14 its -PRON- PRP$ cord-325328-3l3jznkj 64 15 biological biological JJ cord-325328-3l3jznkj 64 16 function function NN cord-325328-3l3jznkj 64 17 . . . cord-325328-3l3jznkj 65 1 Crystal crystal NN cord-325328-3l3jznkj 65 2 structures structure NNS cord-325328-3l3jznkj 65 3 of of IN cord-325328-3l3jznkj 65 4 the the DT cord-325328-3l3jznkj 65 5 riboswitch riboswitch NN cord-325328-3l3jznkj 65 6 - - HYPH cord-325328-3l3jznkj 65 7 hypoxanthine hypoxanthine NN cord-325328-3l3jznkj 65 8 complex complex NN cord-325328-3l3jznkj 65 9 [ [ -LRB- cord-325328-3l3jznkj 65 10 20 20 CD cord-325328-3l3jznkj 65 11 ] ] -RRB- cord-325328-3l3jznkj 65 12 and and CC cord-325328-3l3jznkj 65 13 the the DT cord-325328-3l3jznkj 65 14 riboswitch riboswitch NN cord-325328-3l3jznkj 65 15 - - HYPH cord-325328-3l3jznkj 65 16 guanine guanine NN cord-325328-3l3jznkj 65 17 complex complex NN cord-325328-3l3jznkj 65 18 [ [ -LRB- cord-325328-3l3jznkj 65 19 19 19 CD cord-325328-3l3jznkj 65 20 ] ] -RRB- cord-325328-3l3jznkj 65 21 show show VBP cord-325328-3l3jznkj 65 22 the the DT cord-325328-3l3jznkj 65 23 detail detail NN cord-325328-3l3jznkj 65 24 of of IN cord-325328-3l3jznkj 65 25 this this DT cord-325328-3l3jznkj 65 26 tertiary tertiary JJ cord-325328-3l3jznkj 65 27 interaction interaction NN cord-325328-3l3jznkj 65 28 between between IN cord-325328-3l3jznkj 65 29 these these DT cord-325328-3l3jznkj 65 30 seven seven CD cord-325328-3l3jznkj 65 31 - - HYPH cord-325328-3l3jznkj 65 32 nucleotide nucleotide JJ cord-325328-3l3jznkj 65 33 loops loop NNS cord-325328-3l3jznkj 65 34 , , , cord-325328-3l3jznkj 65 35 as as IN cord-325328-3l3jznkj 65 36 shown show VBN cord-325328-3l3jznkj 65 37 in in IN cord-325328-3l3jznkj 65 38 Figure Figure NNP cord-325328-3l3jznkj 65 39 3 3 CD cord-325328-3l3jznkj 65 40 . . . cord-325328-3l3jznkj 66 1 These these DT cord-325328-3l3jznkj 66 2 quartets quartet NNS cord-325328-3l3jznkj 66 3 are be VBP cord-325328-3l3jznkj 66 4 similar similar JJ cord-325328-3l3jznkj 66 5 to to IN cord-325328-3l3jznkj 66 6 those those DT cord-325328-3l3jznkj 66 7 found find VBN cord-325328-3l3jznkj 66 8 in in IN cord-325328-3l3jznkj 66 9 the the DT cord-325328-3l3jznkj 66 10 SARS SARS NNP cord-325328-3l3jznkj 66 11 virus virus NN cord-325328-3l3jznkj 66 12 s2 s2 NNP cord-325328-3l3jznkj 66 13 m m NNP cord-325328-3l3jznkj 66 14 element element NN cord-325328-3l3jznkj 66 15 ( ( -LRB- cord-325328-3l3jznkj 66 16 see see VB cord-325328-3l3jznkj 66 17 above above RB cord-325328-3l3jznkj 66 18 ) ) -RRB- cord-325328-3l3jznkj 66 19 in in IN cord-325328-3l3jznkj 66 20 that that IN cord-325328-3l3jznkj 66 21 they -PRON- PRP cord-325328-3l3jznkj 66 22 include include VBP cord-325328-3l3jznkj 66 23 Watson Watson NNP cord-325328-3l3jznkj 66 24 - - HYPH cord-325328-3l3jznkj 66 25 Crick Crick NNP cord-325328-3l3jznkj 66 26 pairs pair NNS cord-325328-3l3jznkj 66 27 ( ( -LRB- cord-325328-3l3jznkj 66 28 one one CD cord-325328-3l3jznkj 66 29 base base NN cord-325328-3l3jznkj 66 30 from from IN cord-325328-3l3jznkj 66 31 each each DT cord-325328-3l3jznkj 66 32 loop loop NN cord-325328-3l3jznkj 66 33 ) ) -RRB- cord-325328-3l3jznkj 66 34 , , , cord-325328-3l3jznkj 66 35 but but CC cord-325328-3l3jznkj 66 36 in in IN cord-325328-3l3jznkj 66 37 this this DT cord-325328-3l3jznkj 66 38 case case NN cord-325328-3l3jznkj 66 39 they -PRON- PRP cord-325328-3l3jznkj 66 40 interact interact VBP cord-325328-3l3jznkj 66 41 with with IN cord-325328-3l3jznkj 66 42 non non JJ cord-325328-3l3jznkj 66 43 - - JJ cord-325328-3l3jznkj 66 44 canonical canonical JJ cord-325328-3l3jznkj 66 45 pairs pair NNS cord-325328-3l3jznkj 66 46 ( ( -LRB- cord-325328-3l3jznkj 66 47 formed form VBN cord-325328-3l3jznkj 66 48 between between IN cord-325328-3l3jznkj 66 49 loops loop NNS cord-325328-3l3jznkj 66 50 ) ) -RRB- cord-325328-3l3jznkj 66 51 in in IN cord-325328-3l3jznkj 66 52 their -PRON- PRP$ cord-325328-3l3jznkj 66 53 minor minor JJ cord-325328-3l3jznkj 66 54 groove groove NN cord-325328-3l3jznkj 66 55 . . . cord-325328-3l3jznkj 67 1 This this DT cord-325328-3l3jznkj 67 2 tertiary tertiary JJ cord-325328-3l3jznkj 67 3 interaction interaction NN cord-325328-3l3jznkj 67 4 pulls pull VBZ cord-325328-3l3jznkj 67 5 the the DT cord-325328-3l3jznkj 67 6 loops loop NNS cord-325328-3l3jznkj 67 7 together together RB cord-325328-3l3jznkj 67 8 along along IN cord-325328-3l3jznkj 67 9 with with IN cord-325328-3l3jznkj 67 10 their -PRON- PRP$ cord-325328-3l3jznkj 67 11 attached attach VBN cord-325328-3l3jznkj 67 12 stems stem NNS cord-325328-3l3jznkj 67 13 . . . cord-325328-3l3jznkj 68 1 The the DT cord-325328-3l3jznkj 68 2 Moloney Moloney NNP cord-325328-3l3jznkj 68 3 murine murine JJ cord-325328-3l3jznkj 68 4 leukemia leukemia NN cord-325328-3l3jznkj 68 5 virus virus NN cord-325328-3l3jznkj 68 6 core core NN cord-325328-3l3jznkj 68 7 encapsidation encapsidation NN cord-325328-3l3jznkj 68 8 signal signal NN cord-325328-3l3jznkj 68 9 Specificity Specificity NNP cord-325328-3l3jznkj 68 10 of of IN cord-325328-3l3jznkj 68 11 packaging packaging NN cord-325328-3l3jznkj 68 12 of of IN cord-325328-3l3jznkj 68 13 retroviral retroviral JJ cord-325328-3l3jznkj 68 14 genomes genome NNS cord-325328-3l3jznkj 68 15 is be VBZ cord-325328-3l3jznkj 68 16 a a DT cord-325328-3l3jznkj 68 17 result result NN cord-325328-3l3jznkj 68 18 of of IN cord-325328-3l3jznkj 68 19 interaction interaction NN cord-325328-3l3jznkj 68 20 between between IN cord-325328-3l3jznkj 68 21 nucleocapsid nucleocapsid NN cord-325328-3l3jznkj 68 22 domains domain NNS cord-325328-3l3jznkj 68 23 of of IN cord-325328-3l3jznkj 68 24 the the DT cord-325328-3l3jznkj 68 25 Gag Gag NNP cord-325328-3l3jznkj 68 26 polyproteins polyprotein NNS cord-325328-3l3jznkj 68 27 and and CC cord-325328-3l3jznkj 68 28 the the DT cord-325328-3l3jznkj 68 29 C C NNP cord-325328-3l3jznkj 68 30 - - HYPH cord-325328-3l3jznkj 68 31 site site NN cord-325328-3l3jznkj 68 32 of of IN cord-325328-3l3jznkj 68 33 the the DT cord-325328-3l3jznkj 68 34 viral viral JJ cord-325328-3l3jznkj 68 35 genome genome NN cord-325328-3l3jznkj 68 36 . . . cord-325328-3l3jznkj 69 1 Conserved Conserved NNP cord-325328-3l3jznkj 69 2 RNA RNA NNP cord-325328-3l3jznkj 69 3 secondary secondary JJ cord-325328-3l3jznkj 69 4 structure structure NN cord-325328-3l3jznkj 69 5 elements element NNS cord-325328-3l3jznkj 69 6 within within IN cord-325328-3l3jznkj 69 7 the the DT cord-325328-3l3jznkj 69 8 Csite Csite NNP cord-325328-3l3jznkj 69 9 have have VBP cord-325328-3l3jznkj 69 10 been be VBN cord-325328-3l3jznkj 69 11 identified identify VBN cord-325328-3l3jznkj 69 12 for for IN cord-325328-3l3jznkj 69 13 MMLV MMLV NNP cord-325328-3l3jznkj 69 14 and and CC cord-325328-3l3jznkj 69 15 other other JJ cord-325328-3l3jznkj 69 16 retroviruses retrovirus NNS cord-325328-3l3jznkj 69 17 . . . cord-325328-3l3jznkj 70 1 In in IN cord-325328-3l3jznkj 70 2 MMLV MMLV NNP cord-325328-3l3jznkj 70 3 , , , cord-325328-3l3jznkj 70 4 such such PDT cord-325328-3l3jznkj 70 5 a a DT cord-325328-3l3jznkj 70 6 region region NN cord-325328-3l3jznkj 70 7 , , , cord-325328-3l3jznkj 70 8 which which WDT cord-325328-3l3jznkj 70 9 includes include VBZ cord-325328-3l3jznkj 70 10 three three CD cord-325328-3l3jznkj 70 11 stem stem NN cord-325328-3l3jznkj 70 12 - - HYPH cord-325328-3l3jznkj 70 13 loop loop NN cord-325328-3l3jznkj 70 14 structures structure NNS cord-325328-3l3jznkj 70 15 , , , cord-325328-3l3jznkj 70 16 is be VBZ cord-325328-3l3jznkj 70 17 highly highly RB cord-325328-3l3jznkj 70 18 conserved conserve VBN cord-325328-3l3jznkj 70 19 . . . cord-325328-3l3jznkj 71 1 The the DT cord-325328-3l3jznkj 71 2 sequences sequence NNS cord-325328-3l3jznkj 71 3 of of IN cord-325328-3l3jznkj 71 4 the the DT cord-325328-3l3jznkj 71 5 three three CD cord-325328-3l3jznkj 71 6 stem stem NN cord-325328-3l3jznkj 71 7 - - HYPH cord-325328-3l3jznkj 71 8 loops loop NNS cord-325328-3l3jznkj 71 9 ( ( -LRB- cord-325328-3l3jznkj 71 10 tetraloops tetraloop NNS cord-325328-3l3jznkj 71 11 ) ) -RRB- cord-325328-3l3jznkj 71 12 in in IN cord-325328-3l3jznkj 71 13 this this DT cord-325328-3l3jznkj 71 14 region region NN cord-325328-3l3jznkj 71 15 were be VBD cord-325328-3l3jznkj 71 16 changed change VBN cord-325328-3l3jznkj 71 17 to to TO cord-325328-3l3jznkj 71 18 prevent prevent VB cord-325328-3l3jznkj 71 19 intermolecular intermolecular JJ cord-325328-3l3jznkj 71 20 interaction interaction NN cord-325328-3l3jznkj 71 21 and and CC cord-325328-3l3jznkj 71 22 enhance enhance VB cord-325328-3l3jznkj 71 23 crystallization crystallization NN cord-325328-3l3jznkj 71 24 , , , cord-325328-3l3jznkj 71 25 while while IN cord-325328-3l3jznkj 71 26 retaining retain VBG cord-325328-3l3jznkj 71 27 function function NN cord-325328-3l3jznkj 71 28 . . . cord-325328-3l3jznkj 72 1 The the DT cord-325328-3l3jznkj 72 2 structure structure NN cord-325328-3l3jznkj 72 3 of of IN cord-325328-3l3jznkj 72 4 this this DT cord-325328-3l3jznkj 72 5 engineered engineer VBN cord-325328-3l3jznkj 72 6 , , , cord-325328-3l3jznkj 72 7 functional functional NNP cord-325328-3l3jznkj 72 8 RNA RNA NNP cord-325328-3l3jznkj 72 9 , , , cord-325328-3l3jznkj 72 10 which which WDT cord-325328-3l3jznkj 72 11 corresponds correspond VBZ cord-325328-3l3jznkj 72 12 to to IN cord-325328-3l3jznkj 72 13 the the DT cord-325328-3l3jznkj 72 14 core core NN cord-325328-3l3jznkj 72 15 encapsidation encapsidation NN cord-325328-3l3jznkj 72 16 signal signal NN cord-325328-3l3jznkj 72 17 , , , cord-325328-3l3jznkj 72 18 has have VBZ cord-325328-3l3jznkj 72 19 been be VBN cord-325328-3l3jznkj 72 20 determined determine VBN cord-325328-3l3jznkj 72 21 by by IN cord-325328-3l3jznkj 72 22 NMR NMR NNP cord-325328-3l3jznkj 72 23 methods method NNS cord-325328-3l3jznkj 72 24 [ [ -LRB- cord-325328-3l3jznkj 72 25 2 2 CD cord-325328-3l3jznkj 72 26 ] ] -RRB- cord-325328-3l3jznkj 72 27 . . . cord-325328-3l3jznkj 73 1 As as IN cord-325328-3l3jznkj 73 2 seen see VBN cord-325328-3l3jznkj 73 3 in in IN cord-325328-3l3jznkj 73 4 Figure Figure NNP cord-325328-3l3jznkj 73 5 4 4 CD cord-325328-3l3jznkj 73 6 , , , cord-325328-3l3jznkj 73 7 two two CD cord-325328-3l3jznkj 73 8 of of IN cord-325328-3l3jznkj 73 9 the the DT cord-325328-3l3jznkj 73 10 stem stem NN cord-325328-3l3jznkj 73 11 - - HYPH cord-325328-3l3jznkj 73 12 loops loop NNS cord-325328-3l3jznkj 73 13 form form VBP cord-325328-3l3jznkj 73 14 a a DT cord-325328-3l3jznkj 73 15 coaxial coaxial JJ cord-325328-3l3jznkj 73 16 stack stack NN cord-325328-3l3jznkj 73 17 connected connect VBN cord-325328-3l3jznkj 73 18 to to IN cord-325328-3l3jznkj 73 19 the the DT cord-325328-3l3jznkj 73 20 third third JJ cord-325328-3l3jznkj 73 21 stem stem NN cord-325328-3l3jznkj 73 22 - - HYPH cord-325328-3l3jznkj 73 23 loop loop NN cord-325328-3l3jznkj 73 24 by by IN cord-325328-3l3jznkj 73 25 a a DT cord-325328-3l3jznkj 73 26 flexible flexible JJ cord-325328-3l3jznkj 73 27 linker linker NN cord-325328-3l3jznkj 73 28 . . . cord-325328-3l3jznkj 74 1 In in IN cord-325328-3l3jznkj 74 2 addition addition NN cord-325328-3l3jznkj 74 3 to to IN cord-325328-3l3jznkj 74 4 several several JJ cord-325328-3l3jznkj 74 5 familiar familiar JJ cord-325328-3l3jznkj 74 6 structural structural JJ cord-325328-3l3jznkj 74 7 motifs motif NNS cord-325328-3l3jznkj 74 8 , , , cord-325328-3l3jznkj 74 9 a a DT cord-325328-3l3jznkj 74 10 new new JJ cord-325328-3l3jznkj 74 11 element element NN cord-325328-3l3jznkj 74 12 , , , cord-325328-3l3jznkj 74 13 termed term VBD cord-325328-3l3jznkj 74 14 an an DT cord-325328-3l3jznkj 74 15 ' ' `` cord-325328-3l3jznkj 74 16 A a DT cord-325328-3l3jznkj 74 17 - - HYPH cord-325328-3l3jznkj 74 18 minor minor JJ cord-325328-3l3jznkj 74 19 kink kink NN cord-325328-3l3jznkj 74 20 turn turn NN cord-325328-3l3jznkj 74 21 ' ' '' cord-325328-3l3jznkj 74 22 , , , cord-325328-3l3jznkj 74 23 was be VBD cord-325328-3l3jznkj 74 24 observed observe VBN cord-325328-3l3jznkj 74 25 . . . cord-325328-3l3jznkj 75 1 This this DT cord-325328-3l3jznkj 75 2 structural structural JJ cord-325328-3l3jznkj 75 3 feature feature NN cord-325328-3l3jznkj 75 4 , , , cord-325328-3l3jznkj 75 5 with with IN cord-325328-3l3jznkj 75 6 similarities similarity NNS cord-325328-3l3jznkj 75 7 to to IN cord-325328-3l3jznkj 75 8 both both CC cord-325328-3l3jznkj 75 9 the the DT cord-325328-3l3jznkj 75 10 A A NNP cord-325328-3l3jznkj 75 11 - - HYPH cord-325328-3l3jznkj 75 12 minor minor JJ cord-325328-3l3jznkj 75 13 motif motif NN cord-325328-3l3jznkj 75 14 and and CC cord-325328-3l3jznkj 75 15 a a DT cord-325328-3l3jznkj 75 16 kink kink NN cord-325328-3l3jznkj 75 17 turn turn NN cord-325328-3l3jznkj 75 18 , , , cord-325328-3l3jznkj 75 19 is be VBZ cord-325328-3l3jznkj 75 20 formed form VBN cord-325328-3l3jznkj 75 21 by by IN cord-325328-3l3jznkj 75 22 the the DT cord-325328-3l3jznkj 75 23 interaction interaction NN cord-325328-3l3jznkj 75 24 of of IN cord-325328-3l3jznkj 75 25 an an DT cord-325328-3l3jznkj 75 26 extruded extrude VBN cord-325328-3l3jznkj 75 27 uridine uridine NN cord-325328-3l3jznkj 75 28 and and CC cord-325328-3l3jznkj 75 29 a a DT cord-325328-3l3jznkj 75 30 GGAA GGAA NNP cord-325328-3l3jznkj 75 31 bulge bulge NN cord-325328-3l3jznkj 75 32 . . . cord-325328-3l3jznkj 76 1 In in IN cord-325328-3l3jznkj 76 2 this this DT cord-325328-3l3jznkj 76 3 element element NN cord-325328-3l3jznkj 76 4 , , , cord-325328-3l3jznkj 76 5 two two CD cord-325328-3l3jznkj 76 6 unpaired unpaired JJ cord-325328-3l3jznkj 76 7 adenosines adenosine NNS cord-325328-3l3jznkj 76 8 pack pack NN cord-325328-3l3jznkj 76 9 in in IN cord-325328-3l3jznkj 76 10 the the DT cord-325328-3l3jznkj 76 11 minor minor JJ cord-325328-3l3jznkj 76 12 groove groove NN cord-325328-3l3jznkj 76 13 of of IN cord-325328-3l3jznkj 76 14 a a DT cord-325328-3l3jznkj 76 15 neighboring neighboring NN cord-325328-3l3jznkj 76 16 stem stem NN cord-325328-3l3jznkj 76 17 , , , cord-325328-3l3jznkj 76 18 inducing induce VBG cord-325328-3l3jznkj 76 19 a a DT cord-325328-3l3jznkj 76 20 kink kink NN cord-325328-3l3jznkj 76 21 in in IN cord-325328-3l3jznkj 76 22 the the DT cord-325328-3l3jznkj 76 23 helix helix NN cord-325328-3l3jznkj 76 24 . . . cord-325328-3l3jznkj 77 1 More More JJR cord-325328-3l3jznkj 77 2 structural structural JJ cord-325328-3l3jznkj 77 3 examples example NNS cord-325328-3l3jznkj 77 4 are be VBP cord-325328-3l3jznkj 77 5 needed need VBN cord-325328-3l3jznkj 77 6 to to TO cord-325328-3l3jznkj 77 7 determine determine VB cord-325328-3l3jznkj 77 8 whether whether IN cord-325328-3l3jznkj 77 9 this this DT cord-325328-3l3jznkj 77 10 is be VBZ cord-325328-3l3jznkj 77 11 a a DT cord-325328-3l3jznkj 77 12 recurring recur VBG cord-325328-3l3jznkj 77 13 RNA RNA NNP cord-325328-3l3jznkj 77 14 structural structural JJ cord-325328-3l3jznkj 77 15 motif motif NN cord-325328-3l3jznkj 77 16 or or CC cord-325328-3l3jznkj 77 17 unique unique JJ cord-325328-3l3jznkj 77 18 to to IN cord-325328-3l3jznkj 77 19 this this DT cord-325328-3l3jznkj 77 20 structure structure NN cord-325328-3l3jznkj 77 21 . . . cord-325328-3l3jznkj 78 1 Considering consider VBG cord-325328-3l3jznkj 78 2 the the DT cord-325328-3l3jznkj 78 3 large large JJ cord-325328-3l3jznkj 78 4 fraction fraction NN cord-325328-3l3jznkj 78 5 of of IN cord-325328-3l3jznkj 78 6 RNA RNA NNP cord-325328-3l3jznkj 78 7 that that WDT cord-325328-3l3jznkj 78 8 can can MD cord-325328-3l3jznkj 78 9 be be VB cord-325328-3l3jznkj 78 10 attributed attribute VBN cord-325328-3l3jznkj 78 11 to to IN cord-325328-3l3jznkj 78 12 secondary secondary JJ cord-325328-3l3jznkj 78 13 and and CC cord-325328-3l3jznkj 78 14 tertiary tertiary JJ cord-325328-3l3jznkj 78 15 structure structure NN cord-325328-3l3jznkj 78 16 motifs motif NNS cord-325328-3l3jznkj 78 17 , , , cord-325328-3l3jznkj 78 18 the the DT cord-325328-3l3jznkj 78 19 prediction prediction NN cord-325328-3l3jznkj 78 20 of of IN cord-325328-3l3jznkj 78 21 these these DT cord-325328-3l3jznkj 78 22 motifs motif NNS cord-325328-3l3jznkj 78 23 from from IN cord-325328-3l3jznkj 78 24 sequence sequence NN cord-325328-3l3jznkj 78 25 would would MD cord-325328-3l3jznkj 78 26 be be VB cord-325328-3l3jznkj 78 27 a a DT cord-325328-3l3jznkj 78 28 large large JJ cord-325328-3l3jznkj 78 29 step step NN cord-325328-3l3jznkj 78 30 toward toward IN cord-325328-3l3jznkj 78 31 the the DT cord-325328-3l3jznkj 78 32 prediction prediction NN cord-325328-3l3jznkj 78 33 of of IN cord-325328-3l3jznkj 78 34 RNA RNA NNP cord-325328-3l3jznkj 78 35 three three CD cord-325328-3l3jznkj 78 36 - - HYPH cord-325328-3l3jznkj 78 37 dimensional dimensional JJ cord-325328-3l3jznkj 78 38 structure structure NN cord-325328-3l3jznkj 78 39 . . . cord-325328-3l3jznkj 79 1 Currently currently RB cord-325328-3l3jznkj 79 2 , , , cord-325328-3l3jznkj 79 3 the the DT cord-325328-3l3jznkj 79 4 most most RBS cord-325328-3l3jznkj 79 5 successful successful JJ cord-325328-3l3jznkj 79 6 approach approach NN cord-325328-3l3jznkj 79 7 to to IN cord-325328-3l3jznkj 79 8 predicting predict VBG cord-325328-3l3jznkj 79 9 RNA RNA NNP cord-325328-3l3jznkj 79 10 motifs motif NNS cord-325328-3l3jznkj 79 11 begins begin VBZ cord-325328-3l3jznkj 79 12 by by IN cord-325328-3l3jznkj 79 13 predicting predict VBG cord-325328-3l3jznkj 79 14 the the DT cord-325328-3l3jznkj 79 15 secondary secondary JJ cord-325328-3l3jznkj 79 16 structure structure NN cord-325328-3l3jznkj 79 17 by by IN cord-325328-3l3jznkj 79 18 means mean NNS cord-325328-3l3jznkj 79 19 of of IN cord-325328-3l3jznkj 79 20 either either DT cord-325328-3l3jznkj 79 21 energy energy NN cord-325328-3l3jznkj 79 22 minimization minimization NN cord-325328-3l3jznkj 79 23 using use VBG cord-325328-3l3jznkj 79 24 nearest near JJS cord-325328-3l3jznkj 79 25 neighbor neighbor NN cord-325328-3l3jznkj 79 26 thermodynamic thermodynamic JJ cord-325328-3l3jznkj 79 27 rules rule NNS cord-325328-3l3jznkj 79 28 , , , cord-325328-3l3jznkj 79 29 as as IN cord-325328-3l3jznkj 79 30 implemented implement VBN cord-325328-3l3jznkj 79 31 in in IN cord-325328-3l3jznkj 79 32 MFOLD MFOLD NNP cord-325328-3l3jznkj 79 33 [ [ -LRB- cord-325328-3l3jznkj 79 34 40 40 CD cord-325328-3l3jznkj 79 35 ] ] -RRB- cord-325328-3l3jznkj 79 36 and and CC cord-325328-3l3jznkj 79 37 the the DT cord-325328-3l3jznkj 79 38 Vienna Vienna NNP cord-325328-3l3jznkj 79 39 RNA RNA NNP cord-325328-3l3jznkj 79 40 package package NN cord-325328-3l3jznkj 79 41 [ [ -LRB- cord-325328-3l3jznkj 79 42 41 41 CD cord-325328-3l3jznkj 79 43 ] ] -RRB- cord-325328-3l3jznkj 79 44 , , , cord-325328-3l3jznkj 79 45 or or CC cord-325328-3l3jznkj 79 46 covariation covariation NN cord-325328-3l3jznkj 79 47 analysis analysis NN cord-325328-3l3jznkj 79 48 , , , cord-325328-3l3jznkj 79 49 or or CC cord-325328-3l3jznkj 79 50 a a DT cord-325328-3l3jznkj 79 51 combination combination NN cord-325328-3l3jznkj 79 52 of of IN cord-325328-3l3jznkj 79 53 both both DT cord-325328-3l3jznkj 79 54 [ [ -LRB- cord-325328-3l3jznkj 79 55 42 42 CD cord-325328-3l3jznkj 79 56 ] ] -RRB- cord-325328-3l3jznkj 79 57 . . . cord-325328-3l3jznkj 80 1 Next next RB cord-325328-3l3jznkj 80 2 , , , cord-325328-3l3jznkj 80 3 potential potential JJ cord-325328-3l3jznkj 80 4 motifs motif NNS cord-325328-3l3jznkj 80 5 are be VBP cord-325328-3l3jznkj 80 6 identified identify VBN cord-325328-3l3jznkj 80 7 in in IN cord-325328-3l3jznkj 80 8 the the DT cord-325328-3l3jznkj 80 9 predicted predict VBN cord-325328-3l3jznkj 80 10 RNA RNA NNP cord-325328-3l3jznkj 80 11 structure structure NN cord-325328-3l3jznkj 80 12 Holbrook Holbrook NNP cord-325328-3l3jznkj 80 13 305 305 CD cord-325328-3l3jznkj 81 1 A a DT cord-325328-3l3jznkj 81 2 Watson Watson NNP cord-325328-3l3jznkj 81 3 - - HYPH cord-325328-3l3jznkj 81 4 Crick Crick NNP cord-325328-3l3jznkj 81 5 base base NN cord-325328-3l3jznkj 81 6 quartet quartet NN cord-325328-3l3jznkj 81 7 found find VBD cord-325328-3l3jznkj 81 8 in in IN cord-325328-3l3jznkj 81 9 a a DT cord-325328-3l3jznkj 81 10 highly highly RB cord-325328-3l3jznkj 81 11 conserved conserve VBN cord-325328-3l3jznkj 81 12 region region NN cord-325328-3l3jznkj 81 13 of of IN cord-325328-3l3jznkj 81 14 the the DT cord-325328-3l3jznkj 81 15 SARS SARS NNP cord-325328-3l3jznkj 81 16 virus virus NN cord-325328-3l3jznkj 81 17 genome genome NN cord-325328-3l3jznkj 81 18 . . . cord-325328-3l3jznkj 82 1 The the DT cord-325328-3l3jznkj 82 2 quartet quartet NN cord-325328-3l3jznkj 82 3 is be VBZ cord-325328-3l3jznkj 82 4 shown show VBN cord-325328-3l3jznkj 82 5 in in IN cord-325328-3l3jznkj 82 6 orange orange NNP cord-325328-3l3jznkj 82 7 , , , cord-325328-3l3jznkj 82 8 a a DT cord-325328-3l3jznkj 82 9 GNRA GNRA NNP cord-325328-3l3jznkj 82 10 - - HYPH cord-325328-3l3jznkj 82 11 like like JJ cord-325328-3l3jznkj 82 12 pentaloop pentaloop NN cord-325328-3l3jznkj 82 13 with with IN cord-325328-3l3jznkj 82 14 a a DT cord-325328-3l3jznkj 82 15 closing close VBG cord-325328-3l3jznkj 82 16 base base NN cord-325328-3l3jznkj 82 17 pair pair NN cord-325328-3l3jznkj 82 18 is be VBZ cord-325328-3l3jznkj 82 19 in in IN cord-325328-3l3jznkj 82 20 green green JJ cord-325328-3l3jznkj 82 21 , , , cord-325328-3l3jznkj 82 22 a a DT cord-325328-3l3jznkj 82 23 base base NN cord-325328-3l3jznkj 82 24 pair pair NN cord-325328-3l3jznkj 82 25 from from IN cord-325328-3l3jznkj 82 26 a a DT cord-325328-3l3jznkj 82 27 second second JJ cord-325328-3l3jznkj 82 28 helix helix NN cord-325328-3l3jznkj 82 29 at at IN cord-325328-3l3jznkj 82 30 a a DT cord-325328-3l3jznkj 82 31 sharp sharp JJ cord-325328-3l3jznkj 82 32 angle angle NN cord-325328-3l3jznkj 82 33 to to IN cord-325328-3l3jznkj 82 34 the the DT cord-325328-3l3jznkj 82 35 tetraloop tetraloop NN cord-325328-3l3jznkj 82 36 is be VBZ cord-325328-3l3jznkj 82 37 shown show VBN cord-325328-3l3jznkj 82 38 in in IN cord-325328-3l3jznkj 82 39 magenta magenta NN cord-325328-3l3jznkj 82 40 and and CC cord-325328-3l3jznkj 82 41 a a DT cord-325328-3l3jznkj 82 42 dinucleotide dinucleotide NN cord-325328-3l3jznkj 82 43 linker linker NN cord-325328-3l3jznkj 82 44 between between IN cord-325328-3l3jznkj 82 45 bases basis NNS cord-325328-3l3jznkj 82 46 of of IN cord-325328-3l3jznkj 82 47 the the DT cord-325328-3l3jznkj 82 48 quartet quartet NN cord-325328-3l3jznkj 82 49 is be VBZ cord-325328-3l3jznkj 82 50 in in IN cord-325328-3l3jznkj 82 51 yellow yellow JJ cord-325328-3l3jznkj 82 52 . . . cord-325328-3l3jznkj 83 1 secondary secondary JJ cord-325328-3l3jznkj 83 2 structure structure NN cord-325328-3l3jznkj 83 3 loop loop NN cord-325328-3l3jznkj 83 4 regions region NNS cord-325328-3l3jznkj 83 5 using use VBG cord-325328-3l3jznkj 83 6 sizes size NNS cord-325328-3l3jznkj 83 7 and and CC cord-325328-3l3jznkj 83 8 sequences sequence NNS cord-325328-3l3jznkj 83 9 known know VBN cord-325328-3l3jznkj 83 10 to to TO cord-325328-3l3jznkj 83 11 be be VB cord-325328-3l3jznkj 83 12 compatible compatible JJ cord-325328-3l3jznkj 83 13 with with IN cord-325328-3l3jznkj 83 14 the the DT cord-325328-3l3jznkj 83 15 motifs motif NNS cord-325328-3l3jznkj 83 16 . . . cord-325328-3l3jznkj 84 1 The the DT cord-325328-3l3jznkj 84 2 sequence sequence NN cord-325328-3l3jznkj 84 3 profiles profile NNS cord-325328-3l3jznkj 84 4 of of IN cord-325328-3l3jznkj 84 5 homologous homologous JJ cord-325328-3l3jznkj 84 6 aligned align VBN cord-325328-3l3jznkj 84 7 RNAs rna NNS cord-325328-3l3jznkj 84 8 are be VBP cord-325328-3l3jznkj 84 9 then then RB cord-325328-3l3jznkj 84 10 checked check VBN cord-325328-3l3jznkj 84 11 against against IN cord-325328-3l3jznkj 84 12 these these DT cord-325328-3l3jznkj 84 13 potential potential JJ cord-325328-3l3jznkj 84 14 motifs motif NNS cord-325328-3l3jznkj 84 15 to to TO cord-325328-3l3jznkj 84 16 confirm confirm VB cord-325328-3l3jznkj 84 17 compatibility compatibility NN cord-325328-3l3jznkj 84 18 . . . cord-325328-3l3jznkj 85 1 This this DT cord-325328-3l3jznkj 85 2 approach approach NN cord-325328-3l3jznkj 85 3 was be VBD cord-325328-3l3jznkj 85 4 used use VBN cord-325328-3l3jznkj 85 5 successfully successfully RB cord-325328-3l3jznkj 85 6 to to TO cord-325328-3l3jznkj 85 7 identify identify VB cord-325328-3l3jznkj 85 8 sarcin sarcin NNS cord-325328-3l3jznkj 85 9 - - HYPH cord-325328-3l3jznkj 85 10 ricin ricin NN cord-325328-3l3jznkj 85 11 loops loop NNS cord-325328-3l3jznkj 85 12 and and CC cord-325328-3l3jznkj 85 13 loop loop NN cord-325328-3l3jznkj 85 14 E e NN cord-325328-3l3jznkj 85 15 motifs motif NNS cord-325328-3l3jznkj 85 16 in in IN cord-325328-3l3jznkj 85 17 rRNA rrna NN cord-325328-3l3jznkj 85 18 [ [ -LRB- cord-325328-3l3jznkj 85 19 34 34 CD cord-325328-3l3jznkj 85 20 ] ] -RRB- cord-325328-3l3jznkj 85 21 . . . cord-325328-3l3jznkj 86 1 The the DT cord-325328-3l3jznkj 86 2 ribose ribose NN cord-325328-3l3jznkj 86 3 zipper zipper NN cord-325328-3l3jznkj 86 4 tertiary tertiary JJ cord-325328-3l3jznkj 86 5 structure structure NN cord-325328-3l3jznkj 86 6 motif motif NN cord-325328-3l3jznkj 86 7 has have VBZ cord-325328-3l3jznkj 86 8 been be VBN cord-325328-3l3jznkj 86 9 characterized characterize VBN cord-325328-3l3jznkj 86 10 [ [ -LRB- cord-325328-3l3jznkj 86 11 43 43 CD cord-325328-3l3jznkj 86 12 ] ] -RRB- cord-325328-3l3jznkj 86 13 in in IN cord-325328-3l3jznkj 86 14 terms term NNS cord-325328-3l3jznkj 86 15 of of IN cord-325328-3l3jznkj 86 16 sequence sequence NN cord-325328-3l3jznkj 86 17 and and CC cord-325328-3l3jznkj 86 18 secondary secondary JJ cord-325328-3l3jznkj 86 19 structure structure NN cord-325328-3l3jznkj 86 20 based base VBN cord-325328-3l3jznkj 86 21 on on IN cord-325328-3l3jznkj 86 22 97 97 CD cord-325328-3l3jznkj 86 23 instances instance NNS cord-325328-3l3jznkj 86 24 observed observe VBN cord-325328-3l3jznkj 86 25 in in IN cord-325328-3l3jznkj 86 26 rRNA rRNA NNP cord-325328-3l3jznkj 86 27 . . . cord-325328-3l3jznkj 87 1 The the DT cord-325328-3l3jznkj 87 2 most most RBS cord-325328-3l3jznkj 87 3 common common JJ cord-325328-3l3jznkj 87 4 , , , cord-325328-3l3jznkj 87 5 or or CC cord-325328-3l3jznkj 87 6 canonical canonical JJ cord-325328-3l3jznkj 87 7 , , , cord-325328-3l3jznkj 87 8 type type NN cord-325328-3l3jznkj 87 9 of of IN cord-325328-3l3jznkj 87 10 ribose ribose NN cord-325328-3l3jznkj 87 11 zipper zipper NN cord-325328-3l3jznkj 87 12 shows show VBZ cord-325328-3l3jznkj 87 13 a a DT cord-325328-3l3jznkj 87 14 strong strong JJ cord-325328-3l3jznkj 87 15 sequence sequence NN cord-325328-3l3jznkj 87 16 bias bias NN cord-325328-3l3jznkj 87 17 , , , cord-325328-3l3jznkj 87 18 and and CC cord-325328-3l3jznkj 87 19 is be VBZ cord-325328-3l3jznkj 87 20 found find VBN cord-325328-3l3jznkj 87 21 to to TO cord-325328-3l3jznkj 87 22 link link VB cord-325328-3l3jznkj 87 23 stem stem NN cord-325328-3l3jznkj 87 24 or or CC cord-325328-3l3jznkj 87 25 stem stem NN cord-325328-3l3jznkj 87 26 - - HYPH cord-325328-3l3jznkj 87 27 like like JJ cord-325328-3l3jznkj 87 28 regions region NNS cord-325328-3l3jznkj 87 29 with with IN cord-325328-3l3jznkj 87 30 loop loop NN cord-325328-3l3jznkj 87 31 regions region NNS cord-325328-3l3jznkj 87 32 . . . cord-325328-3l3jznkj 88 1 The the DT cord-325328-3l3jznkj 88 2 residues residue NNS cord-325328-3l3jznkj 88 3 involved involve VBN cord-325328-3l3jznkj 88 4 in in IN cord-325328-3l3jznkj 88 5 ribose ribose NN cord-325328-3l3jznkj 88 6 zippers zipper NNS cord-325328-3l3jznkj 88 7 were be VBD cord-325328-3l3jznkj 88 8 also also RB cord-325328-3l3jznkj 88 9 found find VBN cord-325328-3l3jznkj 88 10 to to TO cord-325328-3l3jznkj 88 11 be be VB cord-325328-3l3jznkj 88 12 phylogenetically phylogenetically RB cord-325328-3l3jznkj 88 13 conserved conserve VBN cord-325328-3l3jznkj 88 14 and and CC cord-325328-3l3jznkj 88 15 to to TO cord-325328-3l3jznkj 88 16 demonstrate demonstrate VB cord-325328-3l3jznkj 88 17 covariation covariation NN cord-325328-3l3jznkj 88 18 patterns pattern NNS cord-325328-3l3jznkj 88 19 . . . cord-325328-3l3jznkj 89 1 Thus thus RB cord-325328-3l3jznkj 89 2 , , , cord-325328-3l3jznkj 89 3 the the DT cord-325328-3l3jznkj 89 4 application application NN cord-325328-3l3jznkj 89 5 of of IN cord-325328-3l3jznkj 89 6 sequence sequence NN cord-325328-3l3jznkj 89 7 and and CC cord-325328-3l3jznkj 89 8 structure structure NN cord-325328-3l3jznkj 89 9 conservation conservation NN cord-325328-3l3jznkj 89 10 analysis analysis NN cord-325328-3l3jznkj 89 11 , , , cord-325328-3l3jznkj 89 12 as as IN cord-325328-3l3jznkj 89 13 used use VBN cord-325328-3l3jznkj 89 14 for for IN cord-325328-3l3jznkj 89 15 the the DT cord-325328-3l3jznkj 89 16 prediction prediction NN cord-325328-3l3jznkj 89 17 of of IN cord-325328-3l3jznkj 89 18 secondary secondary JJ cord-325328-3l3jznkj 89 19 structure structure NN cord-325328-3l3jznkj 89 20 motifs motif NNS cord-325328-3l3jznkj 89 21 , , , cord-325328-3l3jznkj 89 22 is be VBZ cord-325328-3l3jznkj 89 23 also also RB cord-325328-3l3jznkj 89 24 a a DT cord-325328-3l3jznkj 89 25 powerful powerful JJ cord-325328-3l3jznkj 89 26 tool tool NN cord-325328-3l3jznkj 89 27 for for IN cord-325328-3l3jznkj 89 28 predicting predict VBG cord-325328-3l3jznkj 89 29 this this DT cord-325328-3l3jznkj 89 30 tertiary tertiary JJ cord-325328-3l3jznkj 89 31 interaction interaction NN cord-325328-3l3jznkj 89 32 motif motif NN cord-325328-3l3jznkj 89 33 . . . cord-325328-3l3jznkj 90 1 Further further JJ cord-325328-3l3jznkj 90 2 studies study NNS cord-325328-3l3jznkj 90 3 of of IN cord-325328-3l3jznkj 90 4 the the DT cord-325328-3l3jznkj 90 5 application application NN cord-325328-3l3jznkj 90 6 of of IN cord-325328-3l3jznkj 90 7 this this DT cord-325328-3l3jznkj 90 8 approach approach NN cord-325328-3l3jznkj 90 9 to to IN cord-325328-3l3jznkj 90 10 the the DT cord-325328-3l3jznkj 90 11 prediction prediction NN cord-325328-3l3jznkj 90 12 of of IN cord-325328-3l3jznkj 90 13 other other JJ cord-325328-3l3jznkj 90 14 secondary secondary JJ cord-325328-3l3jznkj 90 15 and and CC cord-325328-3l3jznkj 90 16 tertiary tertiary JJ cord-325328-3l3jznkj 90 17 structure structure NN cord-325328-3l3jznkj 90 18 motifs motif NNS cord-325328-3l3jznkj 90 19 are be VBP cord-325328-3l3jznkj 90 20 necessary necessary JJ cord-325328-3l3jznkj 90 21 to to TO cord-325328-3l3jznkj 90 22 confirm confirm VB cord-325328-3l3jznkj 90 23 and and CC cord-325328-3l3jznkj 90 24 make make VB cord-325328-3l3jznkj 90 25 this this DT cord-325328-3l3jznkj 90 26 approach approach NN cord-325328-3l3jznkj 90 27 standard standard NN cord-325328-3l3jznkj 90 28 . . . cord-325328-3l3jznkj 91 1 The the DT cord-325328-3l3jznkj 91 2 focus focus NN cord-325328-3l3jznkj 91 3 of of IN cord-325328-3l3jznkj 91 4 RNA RNA NNP cord-325328-3l3jznkj 91 5 structure structure NN cord-325328-3l3jznkj 91 6 determination determination NN cord-325328-3l3jznkj 91 7 has have VBZ cord-325328-3l3jznkj 91 8 switched switch VBN cord-325328-3l3jznkj 91 9 from from IN cord-325328-3l3jznkj 91 10 small small JJ cord-325328-3l3jznkj 91 11 model model NN cord-325328-3l3jznkj 91 12 structures structure NNS cord-325328-3l3jznkj 91 13 and and CC cord-325328-3l3jznkj 91 14 molecular molecular JJ cord-325328-3l3jznkj 91 15 fragments fragment NNS cord-325328-3l3jznkj 91 16 to to IN cord-325328-3l3jznkj 91 17 large large JJ cord-325328-3l3jznkj 91 18 , , , cord-325328-3l3jznkj 91 19 naturally naturally RB cord-325328-3l3jznkj 91 20 occurring occur VBG cord-325328-3l3jznkj 91 21 biological biological JJ cord-325328-3l3jznkj 91 22 RNAs rna NNS cord-325328-3l3jznkj 91 23 , , , cord-325328-3l3jznkj 91 24 some some DT cord-325328-3l3jznkj 91 25 in in IN cord-325328-3l3jznkj 91 26 protein protein NN cord-325328-3l3jznkj 91 27 complexes complex NNS cord-325328-3l3jznkj 91 28 and and CC cord-325328-3l3jznkj 91 29 some some DT cord-325328-3l3jznkj 91 30 engineered engineer VBN cord-325328-3l3jznkj 91 31 to to TO cord-325328-3l3jznkj 91 32 enhance enhance VB cord-325328-3l3jznkj 91 33 crystallization crystallization NN cord-325328-3l3jznkj 91 34 . . . cord-325328-3l3jznkj 92 1 These these DT cord-325328-3l3jznkj 92 2 larger large JJR cord-325328-3l3jznkj 92 3 , , , cord-325328-3l3jznkj 92 4 more more RBR cord-325328-3l3jznkj 92 5 biological biological JJ cord-325328-3l3jznkj 92 6 structures structure NNS cord-325328-3l3jznkj 92 7 provide provide VBP cord-325328-3l3jznkj 92 8 a a DT cord-325328-3l3jznkj 92 9 diverse diverse JJ cord-325328-3l3jznkj 92 10 picture picture NN cord-325328-3l3jznkj 92 11 , , , cord-325328-3l3jznkj 92 12 and and CC cord-325328-3l3jznkj 92 13 represent represent VB cord-325328-3l3jznkj 92 14 a a DT cord-325328-3l3jznkj 92 15 more more RBR cord-325328-3l3jznkj 92 16 uniform uniform JJ cord-325328-3l3jznkj 92 17 sampling sampling NN cord-325328-3l3jznkj 92 18 of of IN cord-325328-3l3jznkj 92 19 the the DT cord-325328-3l3jznkj 92 20 secondary secondary JJ cord-325328-3l3jznkj 92 21 and and CC cord-325328-3l3jznkj 92 22 tertiary tertiary JJ cord-325328-3l3jznkj 92 23 structure structure NN cord-325328-3l3jznkj 92 24 motifs motif NNS cord-325328-3l3jznkj 92 25 available available JJ cord-325328-3l3jznkj 92 26 to to IN cord-325328-3l3jznkj 92 27 RNA RNA NNP cord-325328-3l3jznkj 92 28 . . . cord-325328-3l3jznkj 93 1 Detailed detailed JJ cord-325328-3l3jznkj 93 2 examination examination NN cord-325328-3l3jznkj 93 3 of of IN cord-325328-3l3jznkj 93 4 recently recently RB cord-325328-3l3jznkj 93 5 determined determine VBN cord-325328-3l3jznkj 93 6 biological biological JJ cord-325328-3l3jznkj 93 7 RNAs rna NNS cord-325328-3l3jznkj 93 8 has have VBZ cord-325328-3l3jznkj 93 9 revealed reveal VBN cord-325328-3l3jznkj 93 10 many many JJ cord-325328-3l3jznkj 93 11 new new JJ cord-325328-3l3jznkj 93 12 structural structural JJ cord-325328-3l3jznkj 93 13 elements element NNS cord-325328-3l3jznkj 93 14 , , , cord-325328-3l3jznkj 93 15 in in IN cord-325328-3l3jznkj 93 16 addition addition NN cord-325328-3l3jznkj 93 17 to to IN cord-325328-3l3jznkj 93 18 finding find VBG cord-325328-3l3jznkj 93 19 repeated repeat VBN cord-325328-3l3jznkj 93 20 examples example NNS cord-325328-3l3jznkj 93 21 of of IN cord-325328-3l3jznkj 93 22 previously previously RB cord-325328-3l3jznkj 93 23 characterized characterize VBN cord-325328-3l3jznkj 93 24 motifs motif NNS cord-325328-3l3jznkj 93 25 . . . cord-325328-3l3jznkj 94 1 In in IN cord-325328-3l3jznkj 94 2 fact fact NN cord-325328-3l3jznkj 94 3 , , , cord-325328-3l3jznkj 94 4 by by IN cord-325328-3l3jznkj 94 5 far far RB cord-325328-3l3jznkj 94 6 the the DT cord-325328-3l3jznkj 94 7 greatest great JJS cord-325328-3l3jznkj 94 8 proportion proportion NN cord-325328-3l3jznkj 94 9 of of IN cord-325328-3l3jznkj 94 10 RNA RNA NNP cord-325328-3l3jznkj 94 11 structure structure NN cord-325328-3l3jznkj 94 12 can can MD cord-325328-3l3jznkj 94 13 be be VB cord-325328-3l3jznkj 94 14 described describe VBN cord-325328-3l3jznkj 94 15 as as IN cord-325328-3l3jznkj 94 16 consisting consist VBG cord-325328-3l3jznkj 94 17 of of IN cord-325328-3l3jznkj 94 18 combinations combination NNS cord-325328-3l3jznkj 94 19 of of IN cord-325328-3l3jznkj 94 20 well well RB cord-325328-3l3jznkj 94 21 - - HYPH cord-325328-3l3jznkj 94 22 characterized characterize VBN cord-325328-3l3jznkj 94 23 structural structural JJ cord-325328-3l3jznkj 94 24 modules module NNS cord-325328-3l3jznkj 94 25 : : : cord-325328-3l3jznkj 94 26 double double JJ cord-325328-3l3jznkj 94 27 helices helix NNS cord-325328-3l3jznkj 94 28 , , , cord-325328-3l3jznkj 94 29 motifs motif NNS cord-325328-3l3jznkj 94 30 in in IN cord-325328-3l3jznkj 94 31 hairpin hairpin JJ cord-325328-3l3jznkj 94 32 loops loop NNS cord-325328-3l3jznkj 94 33 and and CC cord-325328-3l3jznkj 94 34 internal internal JJ cord-325328-3l3jznkj 94 35 loops loop NNS cord-325328-3l3jznkj 94 36 , , , cord-325328-3l3jznkj 94 37 and and CC cord-325328-3l3jznkj 94 38 tertiary tertiary JJ cord-325328-3l3jznkj 94 39 interaction interaction NN cord-325328-3l3jznkj 94 40 motifs motif NNS cord-325328-3l3jznkj 94 41 . . . cord-325328-3l3jznkj 95 1 Although although IN cord-325328-3l3jznkj 95 2 we -PRON- PRP cord-325328-3l3jznkj 95 3 can can MD cord-325328-3l3jznkj 95 4 identify identify VB cord-325328-3l3jznkj 95 5 many many JJ cord-325328-3l3jznkj 95 6 motifs motif NNS cord-325328-3l3jznkj 95 7 in in IN cord-325328-3l3jznkj 95 8 RNA RNA NNP cord-325328-3l3jznkj 95 9 structures structure NNS cord-325328-3l3jznkj 95 10 , , , cord-325328-3l3jznkj 95 11 we -PRON- PRP cord-325328-3l3jznkj 95 12 are be VBP cord-325328-3l3jznkj 95 13 far far RB cord-325328-3l3jznkj 95 14 from from IN cord-325328-3l3jznkj 95 15 having have VBG cord-325328-3l3jznkj 95 16 a a DT cord-325328-3l3jznkj 95 17 complete complete JJ cord-325328-3l3jznkj 95 18 library library NN cord-325328-3l3jznkj 95 19 of of IN cord-325328-3l3jznkj 95 20 RNA RNA NNP cord-325328-3l3jznkj 95 21 structural structural JJ cord-325328-3l3jznkj 95 22 motifs motif NNS cord-325328-3l3jznkj 95 23 , , , cord-325328-3l3jznkj 95 24 and and CC cord-325328-3l3jznkj 95 25 even even RB cord-325328-3l3jznkj 95 26 farther far RBR cord-325328-3l3jznkj 95 27 from from IN cord-325328-3l3jznkj 95 28 understanding understand VBG cord-325328-3l3jznkj 95 29 the the DT cord-325328-3l3jznkj 95 30 context context NN cord-325328-3l3jznkj 95 31 of of IN cord-325328-3l3jznkj 95 32 these these DT cord-325328-3l3jznkj 95 33 motifs motif NNS cord-325328-3l3jznkj 95 34 and and CC cord-325328-3l3jznkj 95 35 their -PRON- PRP$ cord-325328-3l3jznkj 95 36 effect effect NN cord-325328-3l3jznkj 95 37 on on IN cord-325328-3l3jznkj 95 38 the the DT cord-325328-3l3jznkj 95 39 surrounding surround VBG cord-325328-3l3jznkj 95 40 structure structure NN cord-325328-3l3jznkj 95 41 , , , cord-325328-3l3jznkj 95 42 and and CC cord-325328-3l3jznkj 95 43 the the DT cord-325328-3l3jznkj 95 44 ability ability NN cord-325328-3l3jznkj 95 45 to to TO cord-325328-3l3jznkj 95 46 predict predict VB cord-325328-3l3jznkj 95 47 them -PRON- PRP cord-325328-3l3jznkj 95 48 directly directly RB cord-325328-3l3jznkj 95 49 from from IN cord-325328-3l3jznkj 95 50 sequence sequence NN cord-325328-3l3jznkj 95 51 . . . cord-325328-3l3jznkj 96 1 Because because IN cord-325328-3l3jznkj 96 2 the the DT cord-325328-3l3jznkj 96 3 potential potential JJ cord-325328-3l3jznkj 96 4 applications application NNS cord-325328-3l3jznkj 96 5 of of IN cord-325328-3l3jznkj 96 6 being be VBG cord-325328-3l3jznkj 96 7 able able JJ cord-325328-3l3jznkj 96 8 to to TO cord-325328-3l3jznkj 96 9 predict predict VB cord-325328-3l3jznkj 96 10 , , , cord-325328-3l3jznkj 96 11 design design VB cord-325328-3l3jznkj 96 12 [ [ -LRB- cord-325328-3l3jznkj 96 13 44 44 CD cord-325328-3l3jznkj 96 14 ] ] -RRB- cord-325328-3l3jznkj 96 15 and and CC cord-325328-3l3jznkj 96 16 engineer engineer NN cord-325328-3l3jznkj 96 17 [ [ -LRB- cord-325328-3l3jznkj 96 18 37 37 CD cord-325328-3l3jznkj 96 19 , , , cord-325328-3l3jznkj 96 20 38 38 CD cord-325328-3l3jznkj 96 21 ] ] -RRB- cord-325328-3l3jznkj 96 22 RNA RNA NNP cord-325328-3l3jznkj 96 23 structure structure NN cord-325328-3l3jznkj 96 24 through through IN cord-325328-3l3jznkj 96 25 an an DT cord-325328-3l3jznkj 96 26 understanding understanding NN cord-325328-3l3jznkj 96 27 of of IN cord-325328-3l3jznkj 96 28 its -PRON- PRP$ cord-325328-3l3jznkj 96 29 building building NN cord-325328-3l3jznkj 96 30 blocks block NNS cord-325328-3l3jznkj 96 31 are be VBP cord-325328-3l3jznkj 96 32 so so RB cord-325328-3l3jznkj 96 33 great great JJ cord-325328-3l3jznkj 96 34 , , , cord-325328-3l3jznkj 96 35 directed direct VBN cord-325328-3l3jznkj 96 36 effort effort NN cord-325328-3l3jznkj 96 37 in in IN cord-325328-3l3jznkj 96 38 this this DT cord-325328-3l3jznkj 96 39 area area NN cord-325328-3l3jznkj 96 40 is be VBZ cord-325328-3l3jznkj 96 41 warranted warrant VBN cord-325328-3l3jznkj 96 42 . . . cord-325328-3l3jznkj 97 1 Although although IN cord-325328-3l3jznkj 97 2 we -PRON- PRP cord-325328-3l3jznkj 97 3 will will MD cord-325328-3l3jznkj 97 4 eventually eventually RB cord-325328-3l3jznkj 97 5 obtain obtain VB cord-325328-3l3jznkj 97 6 this this DT cord-325328-3l3jznkj 97 7 knowledge knowledge NN cord-325328-3l3jznkj 97 8 through through IN cord-325328-3l3jznkj 97 9 research research NN cord-325328-3l3jznkj 97 10 on on IN cord-325328-3l3jznkj 97 11 individual individual JJ cord-325328-3l3jznkj 97 12 biological biological JJ cord-325328-3l3jznkj 97 13 RNAs rna NNS cord-325328-3l3jznkj 97 14 , , , cord-325328-3l3jznkj 97 15 we -PRON- PRP cord-325328-3l3jznkj 97 16 should should MD cord-325328-3l3jznkj 97 17 consider consider VB cord-325328-3l3jznkj 97 18 a a DT cord-325328-3l3jznkj 97 19 structural structural JJ cord-325328-3l3jznkj 97 20 genomics genomic NNS cord-325328-3l3jznkj 97 21 type type NN cord-325328-3l3jznkj 97 22 project project NN cord-325328-3l3jznkj 97 23 to to TO cord-325328-3l3jznkj 97 24 map map VB cord-325328-3l3jznkj 97 25 the the DT cord-325328-3l3jznkj 97 26 universe universe NN cord-325328-3l3jznkj 97 27 of of IN cord-325328-3l3jznkj 97 28 RNA RNA NNP cord-325328-3l3jznkj 97 29 motifs motif NNS cord-325328-3l3jznkj 97 30 , , , cord-325328-3l3jznkj 97 31 and and CC cord-325328-3l3jznkj 97 32 a a DT cord-325328-3l3jznkj 97 33 parallel parallel JJ cord-325328-3l3jznkj 97 34 computational computational JJ cord-325328-3l3jznkj 97 35 effort effort NN cord-325328-3l3jznkj 97 36 to to TO cord-325328-3l3jznkj 97 37 predict predict VB cord-325328-3l3jznkj 97 38 motifs motif NNS cord-325328-3l3jznkj 97 39 from from IN cord-325328-3l3jznkj 97 40 sequence sequence NN cord-325328-3l3jznkj 97 41 and and CC cord-325328-3l3jznkj 97 42 determine determine VB cord-325328-3l3jznkj 97 43 how how WRB cord-325328-3l3jznkj 97 44 they -PRON- PRP cord-325328-3l3jznkj 97 45 interact interact VBP cord-325328-3l3jznkj 97 46 combinatorially combinatorially RB cord-325328-3l3jznkj 97 47 to to TO cord-325328-3l3jznkj 97 48 build build VB cord-325328-3l3jznkj 97 49 up up RP cord-325328-3l3jznkj 97 50 an an DT cord-325328-3l3jznkj 97 51 overall overall JJ cord-325328-3l3jznkj 97 52 RNA RNA NNP cord-325328-3l3jznkj 97 53 structure structure NN cord-325328-3l3jznkj 97 54 . . . cord-325328-3l3jznkj 98 1 An an DT cord-325328-3l3jznkj 98 2 emerging emerge VBG cord-325328-3l3jznkj 98 3 trend trend NN cord-325328-3l3jznkj 98 4 in in IN cord-325328-3l3jznkj 98 5 RNA RNA NNP cord-325328-3l3jznkj 98 6 structural structural JJ cord-325328-3l3jznkj 98 7 biology biology NN cord-325328-3l3jznkj 98 8 is be VBZ cord-325328-3l3jznkj 98 9 the the DT cord-325328-3l3jznkj 98 10 association association NN cord-325328-3l3jznkj 98 11 of of IN cord-325328-3l3jznkj 98 12 RNA RNA NNP cord-325328-3l3jznkj 98 13 secondary secondary JJ cord-325328-3l3jznkj 98 14 structure structure NN cord-325328-3l3jznkj 98 15 and and CC cord-325328-3l3jznkj 98 16 tertiary tertiary JJ cord-325328-3l3jznkj 98 17 interaction interaction NN cord-325328-3l3jznkj 98 18 motifs motif NNS cord-325328-3l3jznkj 98 19 with with IN cord-325328-3l3jznkj 98 20 human human JJ cord-325328-3l3jznkj 98 21 disease disease NN cord-325328-3l3jznkj 98 22 . . . cord-325328-3l3jznkj 99 1 Three three CD cord-325328-3l3jznkj 99 2 examples example NNS cord-325328-3l3jznkj 99 3 have have VBP cord-325328-3l3jznkj 99 4 recently recently RB cord-325328-3l3jznkj 99 5 appeared appear VBN cord-325328-3l3jznkj 99 6 in in IN cord-325328-3l3jznkj 99 7 the the DT cord-325328-3l3jznkj 99 8 literature literature NN cord-325328-3l3jznkj 99 9 recognizing recognize VBG cord-325328-3l3jznkj 99 10 these these DT cord-325328-3l3jznkj 99 11 relationships relationship NNS cord-325328-3l3jznkj 99 12 and and CC cord-325328-3l3jznkj 99 13 correlating correlate VBG cord-325328-3l3jznkj 99 14 them -PRON- PRP cord-325328-3l3jznkj 99 15 with with IN cord-325328-3l3jznkj 99 16 specific specific JJ cord-325328-3l3jznkj 99 17 structures structure NNS cord-325328-3l3jznkj 99 18 . . . cord-325328-3l3jznkj 100 1 The the DT cord-325328-3l3jznkj 100 2 most most RBS cord-325328-3l3jznkj 100 3 recent recent JJ cord-325328-3l3jznkj 100 4 of of IN cord-325328-3l3jznkj 100 5 these these DT cord-325328-3l3jznkj 100 6 is be VBZ cord-325328-3l3jznkj 100 7 a a DT cord-325328-3l3jznkj 100 8 proposed propose VBN cord-325328-3l3jznkj 100 9 RNA rna NN cord-325328-3l3jznkj 100 10 target target NN cord-325328-3l3jznkj 100 11 , , , cord-325328-3l3jznkj 100 12 306 306 CD cord-325328-3l3jznkj 100 13 Sequences Sequences NNPS cord-325328-3l3jznkj 100 14 and and CC cord-325328-3l3jznkj 100 15 topology topology NN cord-325328-3l3jznkj 100 16 Interacting interact VBG cord-325328-3l3jznkj 100 17 hairpin hairpin JJ cord-325328-3l3jznkj 100 18 loops loop NNS cord-325328-3l3jznkj 100 19 from from IN cord-325328-3l3jznkj 100 20 the the DT cord-325328-3l3jznkj 100 21 guanine guanine NN cord-325328-3l3jznkj 100 22 - - HYPH cord-325328-3l3jznkj 100 23 responsive responsive JJ cord-325328-3l3jznkj 100 24 riboswitch riboswitch NN cord-325328-3l3jznkj 100 25 . . . cord-325328-3l3jznkj 101 1 One one CD cord-325328-3l3jznkj 101 2 loop loop NN cord-325328-3l3jznkj 101 3 is be VBZ cord-325328-3l3jznkj 101 4 in in IN cord-325328-3l3jznkj 101 5 cyan cyan NN cord-325328-3l3jznkj 101 6 and and CC cord-325328-3l3jznkj 101 7 the the DT cord-325328-3l3jznkj 101 8 other other JJ cord-325328-3l3jznkj 101 9 is be VBZ cord-325328-3l3jznkj 101 10 in in IN cord-325328-3l3jznkj 101 11 magenta magenta NN cord-325328-3l3jznkj 101 12 , , , cord-325328-3l3jznkj 101 13 with with IN cord-325328-3l3jznkj 101 14 stacked stack VBN cord-325328-3l3jznkj 101 15 quartets quartet NNS cord-325328-3l3jznkj 101 16 in in IN cord-325328-3l3jznkj 101 17 the the DT cord-325328-3l3jznkj 101 18 loops loop NNS cord-325328-3l3jznkj 101 19 colored color VBN cord-325328-3l3jznkj 101 20 yellow yellow JJ cord-325328-3l3jznkj 101 21 and and CC cord-325328-3l3jznkj 101 22 orange orange NN cord-325328-3l3jznkj 101 23 . . . cord-325328-3l3jznkj 102 1 Helical helical JJ cord-325328-3l3jznkj 102 2 stems stem NNS cord-325328-3l3jznkj 102 3 of of IN cord-325328-3l3jznkj 102 4 the the DT cord-325328-3l3jznkj 102 5 hairpin hairpin JJ cord-325328-3l3jznkj 102 6 loops loop NNS cord-325328-3l3jznkj 102 7 are be VBP cord-325328-3l3jznkj 102 8 colored color VBN cord-325328-3l3jznkj 102 9 blue blue JJ cord-325328-3l3jznkj 102 10 . . . cord-325328-3l3jznkj 103 1 MMLV MMLV NNP cord-325328-3l3jznkj 103 2 core core NN cord-325328-3l3jznkj 103 3 encapsidation encapsidation NN cord-325328-3l3jznkj 103 4 signal signal NN cord-325328-3l3jznkj 103 5 . . . cord-325328-3l3jznkj 104 1 Green Green NNP cord-325328-3l3jznkj 104 2 , , , cord-325328-3l3jznkj 104 3 GNRA GNRA NNP cord-325328-3l3jznkj 104 4 tetraloop tetraloop NN cord-325328-3l3jznkj 104 5 ; ; : cord-325328-3l3jznkj 104 6 salmon salmon NN cord-325328-3l3jznkj 104 7 , , , cord-325328-3l3jznkj 104 8 disordered disordered JJ cord-325328-3l3jznkj 104 9 tetraloop tetraloop NN cord-325328-3l3jznkj 104 10 ; ; : cord-325328-3l3jznkj 104 11 violet violet NN cord-325328-3l3jznkj 104 12 , , , cord-325328-3l3jznkj 104 13 Watson Watson NNP cord-325328-3l3jznkj 104 14 - - HYPH cord-325328-3l3jznkj 104 15 Crick Crick NNP cord-325328-3l3jznkj 104 16 double double JJ cord-325328-3l3jznkj 104 17 helix helix NN cord-325328-3l3jznkj 104 18 ; ; , cord-325328-3l3jznkj 104 19 blue blue JJ cord-325328-3l3jznkj 104 20 , , , cord-325328-3l3jznkj 104 21 non non JJ cord-325328-3l3jznkj 104 22 - - JJ cord-325328-3l3jznkj 104 23 canonical canonical JJ cord-325328-3l3jznkj 104 24 base base NN cord-325328-3l3jznkj 104 25 pairs pair NNS cord-325328-3l3jznkj 104 26 ; ; : cord-325328-3l3jznkj 104 27 cyan cyan NNP cord-325328-3l3jznkj 104 28 , , , cord-325328-3l3jznkj 104 29 base base VB cord-325328-3l3jznkj 104 30 triple triple JJ cord-325328-3l3jznkj 104 31 ; ; : cord-325328-3l3jznkj 104 32 orange orange NN cord-325328-3l3jznkj 104 33 , , , cord-325328-3l3jznkj 104 34 A A NNP cord-325328-3l3jznkj 104 35 - - HYPH cord-325328-3l3jznkj 104 36 minor minor JJ cord-325328-3l3jznkj 104 37 K k NN cord-325328-3l3jznkj 104 38 - - HYPH cord-325328-3l3jznkj 104 39 turn turn NN cord-325328-3l3jznkj 104 40 ; ; : cord-325328-3l3jznkj 104 41 yellow yellow JJ cord-325328-3l3jznkj 104 42 , , , cord-325328-3l3jznkj 104 43 linker linker NN cord-325328-3l3jznkj 104 44 region region NN cord-325328-3l3jznkj 104 45 and and CC cord-325328-3l3jznkj 104 46 bulge bulge NN cord-325328-3l3jznkj 104 47 base base NN cord-325328-3l3jznkj 104 48 . . . cord-325328-3l3jznkj 105 1 formed form VBN cord-325328-3l3jznkj 105 2 by by IN cord-325328-3l3jznkj 105 3 kissing kiss VBG cord-325328-3l3jznkj 105 4 hairpin hairpin NN cord-325328-3l3jznkj 105 5 loop loop NN cord-325328-3l3jznkj 105 6 tertiary tertiary JJ cord-325328-3l3jznkj 105 7 interaction interaction NN cord-325328-3l3jznkj 105 8 motifs motif NNS cord-325328-3l3jznkj 105 9 , , , cord-325328-3l3jznkj 105 10 for for IN cord-325328-3l3jznkj 105 11 the the DT cord-325328-3l3jznkj 105 12 binding binding NN cord-325328-3l3jznkj 105 13 of of IN cord-325328-3l3jznkj 105 14 the the DT cord-325328-3l3jznkj 105 15 KH2 KH2 NNP cord-325328-3l3jznkj 105 16 domain domain NN cord-325328-3l3jznkj 105 17 of of IN cord-325328-3l3jznkj 105 18 the the DT cord-325328-3l3jznkj 105 19 fragile fragile JJ cord-325328-3l3jznkj 105 20 - - HYPH cord-325328-3l3jznkj 105 21 X x NN cord-325328-3l3jznkj 105 22 mental mental JJ cord-325328-3l3jznkj 105 23 retardation retardation NN cord-325328-3l3jznkj 105 24 protein protein NN cord-325328-3l3jznkj 105 25 ( ( -LRB- cord-325328-3l3jznkj 105 26 FMRP FMRP NNP cord-325328-3l3jznkj 105 27 ) ) -RRB- cord-325328-3l3jznkj 106 1 [ [ -LRB- cord-325328-3l3jznkj 106 2 45 45 CD cord-325328-3l3jznkj 106 3 ] ] -RRB- cord-325328-3l3jznkj 106 4 . . . cord-325328-3l3jznkj 107 1 This this DT cord-325328-3l3jznkj 107 2 complex complex JJ cord-325328-3l3jznkj 107 3 interaction interaction NN cord-325328-3l3jznkj 107 4 competes compete VBZ cord-325328-3l3jznkj 107 5 with with IN cord-325328-3l3jznkj 107 6 the the DT cord-325328-3l3jznkj 107 7 binding binding NN cord-325328-3l3jznkj 107 8 of of IN cord-325328-3l3jznkj 107 9 FMRP FMRP NNP cord-325328-3l3jznkj 107 10 to to IN cord-325328-3l3jznkj 107 11 brain brain NN cord-325328-3l3jznkj 107 12 polyribosomes polyribosome NNS cord-325328-3l3jznkj 107 13 and and CC cord-325328-3l3jznkj 107 14 is be VBZ cord-325328-3l3jznkj 107 15 associated associate VBN cord-325328-3l3jznkj 107 16 with with IN cord-325328-3l3jznkj 107 17 a a DT cord-325328-3l3jznkj 107 18 crucial crucial JJ cord-325328-3l3jznkj 107 19 known know VBN cord-325328-3l3jznkj 107 20 mutation mutation NN cord-325328-3l3jznkj 107 21 . . . cord-325328-3l3jznkj 108 1 Another another DT cord-325328-3l3jznkj 108 2 example example NN cord-325328-3l3jznkj 108 3 is be VBZ cord-325328-3l3jznkj 108 4 a a DT cord-325328-3l3jznkj 108 5 proposed propose VBN cord-325328-3l3jznkj 108 6 explanation explanation NN cord-325328-3l3jznkj 108 7 for for IN cord-325328-3l3jznkj 108 8 lead lead JJ cord-325328-3l3jznkj 108 9 toxicity toxicity NN cord-325328-3l3jznkj 108 10 by by IN cord-325328-3l3jznkj 108 11 hydrolysis hydrolysis NN cord-325328-3l3jznkj 108 12 of of IN cord-325328-3l3jznkj 108 13 mRNAs mRNAs NNPS cord-325328-3l3jznkj 108 14 containing contain VBG cord-325328-3l3jznkj 108 15 the the DT cord-325328-3l3jznkj 108 16 leadzyme leadzyme NNS cord-325328-3l3jznkj 108 17 motif motif NN cord-325328-3l3jznkj 108 18 [ [ -LRB- cord-325328-3l3jznkj 108 19 46 46 CD cord-325328-3l3jznkj 108 20 ] ] -RRB- cord-325328-3l3jznkj 108 21 . . . cord-325328-3l3jznkj 109 1 Finally finally RB cord-325328-3l3jznkj 109 2 , , , cord-325328-3l3jznkj 109 3 models model NNS cord-325328-3l3jznkj 109 4 of of IN cord-325328-3l3jznkj 109 5 the the DT cord-325328-3l3jznkj 109 6 role role NN cord-325328-3l3jznkj 109 7 of of IN cord-325328-3l3jznkj 109 8 mRNA mRNA NNP cord-325328-3l3jznkj 109 9 secondary secondary JJ cord-325328-3l3jznkj 109 10 structure structure NN cord-325328-3l3jznkj 109 11 in in IN cord-325328-3l3jznkj 109 12 a a DT cord-325328-3l3jznkj 109 13 variety variety NN cord-325328-3l3jznkj 109 14 of of IN cord-325328-3l3jznkj 109 15 human human JJ cord-325328-3l3jznkj 109 16 neurodegenerative neurodegenerative JJ cord-325328-3l3jznkj 109 17 diseases disease NNS cord-325328-3l3jznkj 109 18 ( ( -LRB- cord-325328-3l3jznkj 109 19 trinucleotide trinucleotide NNP cord-325328-3l3jznkj 109 20 repeat repeat VB cord-325328-3l3jznkj 109 21 expansion expansion NN cord-325328-3l3jznkj 109 22 diseases disease NNS cord-325328-3l3jznkj 109 23 ) ) -RRB- cord-325328-3l3jznkj 109 24 caused cause VBN cord-325328-3l3jznkj 109 25 by by IN cord-325328-3l3jznkj 109 26 the the DT cord-325328-3l3jznkj 109 27 expansion expansion NN cord-325328-3l3jznkj 109 28 of of IN cord-325328-3l3jznkj 109 29 CAG CAG NNP cord-325328-3l3jznkj 109 30 repeats repeat VBZ cord-325328-3l3jznkj 109 31 in in IN cord-325328-3l3jznkj 109 32 the the DT cord-325328-3l3jznkj 109 33 open open JJ cord-325328-3l3jznkj 109 34 reading reading NN cord-325328-3l3jznkj 109 35 frames frame NNS cord-325328-3l3jznkj 109 36 of of IN cord-325328-3l3jznkj 109 37 certain certain JJ cord-325328-3l3jznkj 109 38 genes gene NNS cord-325328-3l3jznkj 109 39 have have VBP cord-325328-3l3jznkj 109 40 been be VBN cord-325328-3l3jznkj 109 41 proposed propose VBN cord-325328-3l3jznkj 109 42 and and CC cord-325328-3l3jznkj 109 43 are be VBP cord-325328-3l3jznkj 109 44 under under IN cord-325328-3l3jznkj 109 45 active active JJ cord-325328-3l3jznkj 109 46 study study NN cord-325328-3l3jznkj 109 47 [ [ -LRB- cord-325328-3l3jznkj 109 48 47 47 CD cord-325328-3l3jznkj 109 49 , , , cord-325328-3l3jznkj 109 50 48 48 CD cord-325328-3l3jznkj 109 51 ] ] -RRB- cord-325328-3l3jznkj 109 52 . . . cord-325328-3l3jznkj 110 1 Crystallization crystallization NN cord-325328-3l3jznkj 110 2 of of IN cord-325328-3l3jznkj 110 3 RNA RNA NNP cord-325328-3l3jznkj 110 4 and and CC cord-325328-3l3jznkj 110 5 RNA RNA NNP cord-325328-3l3jznkj 110 6 - - HYPH cord-325328-3l3jznkj 110 7 protein protein NN cord-325328-3l3jznkj 110 8 complexes complex NNS cord-325328-3l3jznkj 110 9 NMR NMR NNP cord-325328-3l3jznkj 110 10 structure structure NN cord-325328-3l3jznkj 110 11 of of IN cord-325328-3l3jznkj 110 12 the the DT cord-325328-3l3jznkj 110 13 101-nucleotide 101-nucleotide CD cord-325328-3l3jznkj 110 14 core core NN cord-325328-3l3jznkj 110 15 encapsidation encapsidation NN cord-325328-3l3jznkj 110 16 signal signal NN cord-325328-3l3jznkj 110 17 of of IN cord-325328-3l3jznkj 110 18 the the DT cord-325328-3l3jznkj 110 19 Moloney Moloney NNP cord-325328-3l3jznkj 110 20 murine murine JJ cord-325328-3l3jznkj 110 21 leukemia leukemia NN cord-325328-3l3jznkj 110 22 virus virus NN cord-325328-3l3jznkj 111 1 The the DT cord-325328-3l3jznkj 111 2 RNA RNA NNP cord-325328-3l3jznkj 111 3 structure structure NN cord-325328-3l3jznkj 111 4 of of IN cord-325328-3l3jznkj 111 5 the the DT cord-325328-3l3jznkj 111 6 core core NN cord-325328-3l3jznkj 111 7 recognition recognition NN cord-325328-3l3jznkj 111 8 signal signal NN cord-325328-3l3jznkj 111 9 for for IN cord-325328-3l3jznkj 111 10 encapsidation encapsidation NN cord-325328-3l3jznkj 111 11 of of IN cord-325328-3l3jznkj 111 12 the the DT cord-325328-3l3jznkj 111 13 positive positive JJ cord-325328-3l3jznkj 111 14 strand strand NN cord-325328-3l3jznkj 111 15 genome genome NN cord-325328-3l3jznkj 111 16 of of IN cord-325328-3l3jznkj 111 17 MMLV MMLV NNP cord-325328-3l3jznkj 111 18 is be VBZ cord-325328-3l3jznkj 111 19 reported report VBN cord-325328-3l3jznkj 111 20 . . . cord-325328-3l3jznkj 112 1 This this DT cord-325328-3l3jznkj 112 2 is be VBZ cord-325328-3l3jznkj 112 3 the the DT cord-325328-3l3jznkj 112 4 largest large JJS cord-325328-3l3jznkj 112 5 NMR NMR NNP cord-325328-3l3jznkj 112 6 structure structure NN cord-325328-3l3jznkj 112 7 of of IN cord-325328-3l3jznkj 112 8 an an DT cord-325328-3l3jznkj 112 9 RNA RNA NNP cord-325328-3l3jznkj 112 10 determined determined JJ cord-325328-3l3jznkj 112 11 to to IN cord-325328-3l3jznkj 112 12 date date NN cord-325328-3l3jznkj 112 13 The the DT cord-325328-3l3jznkj 112 14 Nucleic Nucleic NNP cord-325328-3l3jznkj 112 15 Acid acid NN cord-325328-3l3jznkj 112 16 Database database NN cord-325328-3l3jznkj 112 17 : : : cord-325328-3l3jznkj 112 18 a a DT cord-325328-3l3jznkj 112 19 comprehensive comprehensive JJ cord-325328-3l3jznkj 112 20 relational relational JJ cord-325328-3l3jznkj 112 21 database database NN cord-325328-3l3jznkj 112 22 of of IN cord-325328-3l3jznkj 112 23 three three CD cord-325328-3l3jznkj 112 24 - - HYPH cord-325328-3l3jznkj 112 25 dimensional dimensional JJ cord-325328-3l3jznkj 112 26 structures structure NNS cord-325328-3l3jznkj 112 27 of of IN cord-325328-3l3jznkj 112 28 nucleic nucleic JJ cord-325328-3l3jznkj 112 29 acids acid NNS cord-325328-3l3jznkj 112 30 Analysis Analysis NNP cord-325328-3l3jznkj 112 31 of of IN cord-325328-3l3jznkj 112 32 RNA RNA NNP cord-325328-3l3jznkj 112 33 motifs motif NNS cord-325328-3l3jznkj 113 1 The the DT cord-325328-3l3jznkj 113 2 complete complete JJ cord-325328-3l3jznkj 113 3 atomic atomic JJ cord-325328-3l3jznkj 113 4 structure structure NN cord-325328-3l3jznkj 113 5 of of IN cord-325328-3l3jznkj 113 6 the the DT cord-325328-3l3jznkj 113 7 large large JJ cord-325328-3l3jznkj 113 8 ribosomal ribosomal JJ cord-325328-3l3jznkj 113 9 subunit subunit NN cord-325328-3l3jznkj 113 10 at at IN cord-325328-3l3jznkj 113 11 2.4 2.4 CD cord-325328-3l3jznkj 113 12 Å å NN cord-325328-3l3jznkj 113 13 resolution resolution NN cord-325328-3l3jznkj 113 14 High high JJ cord-325328-3l3jznkj 113 15 resolution resolution NN cord-325328-3l3jznkj 113 16 structure structure NN cord-325328-3l3jznkj 113 17 of of IN cord-325328-3l3jznkj 113 18 the the DT cord-325328-3l3jznkj 113 19 large large JJ cord-325328-3l3jznkj 113 20 ribosomal ribosomal JJ cord-325328-3l3jznkj 113 21 subunit subunit NN cord-325328-3l3jznkj 113 22 from from IN cord-325328-3l3jznkj 113 23 a a DT cord-325328-3l3jznkj 113 24 mesophilic mesophilic FW cord-325328-3l3jznkj 113 25 eubacterium eubacterium NN cord-325328-3l3jznkj 113 26 Crystal Crystal NNP cord-325328-3l3jznkj 113 27 structure structure NN cord-325328-3l3jznkj 113 28 of of IN cord-325328-3l3jznkj 113 29 the the DT cord-325328-3l3jznkj 113 30 30S 30s CD cord-325328-3l3jznkj 113 31 ribosomal ribosomal JJ cord-325328-3l3jznkj 113 32 subunit subunit NN cord-325328-3l3jznkj 113 33 from from IN cord-325328-3l3jznkj 113 34 Thermus Thermus NNP cord-325328-3l3jznkj 113 35 thermophilus thermophilus NNP cord-325328-3l3jznkj 113 36 : : : cord-325328-3l3jznkj 113 37 purification purification NN cord-325328-3l3jznkj 113 38 , , , cord-325328-3l3jznkj 113 39 crystallization crystallization NN cord-325328-3l3jznkj 113 40 and and CC cord-325328-3l3jznkj 113 41 structure structure NN cord-325328-3l3jznkj 113 42 determination determination NN cord-325328-3l3jznkj 114 1 The the DT cord-325328-3l3jznkj 114 2 roles role NNS cord-325328-3l3jznkj 114 3 of of IN cord-325328-3l3jznkj 114 4 ribosomal ribosomal JJ cord-325328-3l3jznkj 114 5 proteins protein NNS cord-325328-3l3jznkj 114 6 in in IN cord-325328-3l3jznkj 114 7 the the DT cord-325328-3l3jznkj 114 8 structure structure NN cord-325328-3l3jznkj 114 9 assembly assembly NN cord-325328-3l3jznkj 114 10 , , , cord-325328-3l3jznkj 114 11 and and CC cord-325328-3l3jznkj 114 12 evolution evolution NN cord-325328-3l3jznkj 114 13 of of IN cord-325328-3l3jznkj 114 14 the the DT cord-325328-3l3jznkj 114 15 large large JJ cord-325328-3l3jznkj 114 16 ribosomal ribosomal JJ cord-325328-3l3jznkj 114 17 subunit subunit NN cord-325328-3l3jznkj 115 1 The the DT cord-325328-3l3jznkj 115 2 contribution contribution NN cord-325328-3l3jznkj 115 3 of of IN cord-325328-3l3jznkj 115 4 metal metal NN cord-325328-3l3jznkj 115 5 ions ion NNS cord-325328-3l3jznkj 115 6 to to IN cord-325328-3l3jznkj 115 7 the the DT cord-325328-3l3jznkj 115 8 structural structural JJ cord-325328-3l3jznkj 115 9 stability stability NN cord-325328-3l3jznkj 115 10 of of IN cord-325328-3l3jznkj 115 11 the the DT cord-325328-3l3jznkj 115 12 large large JJ cord-325328-3l3jznkj 115 13 ribosomal ribosomal JJ cord-325328-3l3jznkj 115 14 subunit subunit NN cord-325328-3l3jznkj 115 15 Functional functional JJ cord-325328-3l3jznkj 115 16 insights insight NNS cord-325328-3l3jznkj 115 17 from from IN cord-325328-3l3jznkj 115 18 the the DT cord-325328-3l3jznkj 115 19 structure structure NN cord-325328-3l3jznkj 115 20 of of IN cord-325328-3l3jznkj 115 21 the the DT cord-325328-3l3jznkj 115 22 30S 30s CD cord-325328-3l3jznkj 115 23 ribosomal ribosomal JJ cord-325328-3l3jznkj 115 24 subunit subunit NN cord-325328-3l3jznkj 115 25 and and CC cord-325328-3l3jznkj 115 26 its -PRON- PRP$ cord-325328-3l3jznkj 115 27 interactions interaction NNS cord-325328-3l3jznkj 115 28 with with IN cord-325328-3l3jznkj 115 29 antibiotics antibiotic NNS cord-325328-3l3jznkj 115 30 Atomic atomic JJ cord-325328-3l3jznkj 115 31 structures structure NNS cord-325328-3l3jznkj 115 32 of of IN cord-325328-3l3jznkj 115 33 the the DT cord-325328-3l3jznkj 115 34 30S 30s CD cord-325328-3l3jznkj 115 35 subunit subunit NN cord-325328-3l3jznkj 115 36 and and CC cord-325328-3l3jznkj 115 37 its -PRON- PRP$ cord-325328-3l3jznkj 115 38 complexes complex NNS cord-325328-3l3jznkj 115 39 with with IN cord-325328-3l3jznkj 115 40 ligands ligand NNS cord-325328-3l3jznkj 115 41 and and CC cord-325328-3l3jznkj 115 42 antibiotics antibiotic NNS cord-325328-3l3jznkj 115 43 Crystal Crystal NNP cord-325328-3l3jznkj 115 44 structure structure NN cord-325328-3l3jznkj 115 45 of of IN cord-325328-3l3jznkj 115 46 an an DT cord-325328-3l3jznkj 115 47 initiation initiation NN cord-325328-3l3jznkj 115 48 factor factor NN cord-325328-3l3jznkj 115 49 bound bind VBN cord-325328-3l3jznkj 115 50 to to IN cord-325328-3l3jznkj 115 51 the the DT cord-325328-3l3jznkj 115 52 30S 30s CD cord-325328-3l3jznkj 115 53 ribosomal ribosomal JJ cord-325328-3l3jznkj 115 54 subunit subunit NN cord-325328-3l3jznkj 115 55 Crystal Crystal NNP cord-325328-3l3jznkj 115 56 structure structure NN cord-325328-3l3jznkj 115 57 of of IN cord-325328-3l3jznkj 115 58 a a DT cord-325328-3l3jznkj 115 59 group group NN cord-325328-3l3jznkj 115 60 I -PRON- PRP cord-325328-3l3jznkj 115 61 intron intron NN cord-325328-3l3jznkj 115 62 splicing splice VBG cord-325328-3l3jznkj 115 63 intermediate intermediate JJ cord-325328-3l3jznkj 115 64 Crystal Crystal NNP cord-325328-3l3jznkj 115 65 structure structure NN cord-325328-3l3jznkj 115 66 of of IN cord-325328-3l3jznkj 115 67 a a DT cord-325328-3l3jznkj 115 68 self self NN cord-325328-3l3jznkj 115 69 - - HYPH cord-325328-3l3jznkj 115 70 splicing splice VBG cord-325328-3l3jznkj 115 71 group group NN cord-325328-3l3jznkj 116 1 I -PRON- PRP cord-325328-3l3jznkj 116 2 intron intron VBP cord-325328-3l3jznkj 116 3 with with IN cord-325328-3l3jznkj 116 4 both both DT cord-325328-3l3jznkj 116 5 exons exon NNS cord-325328-3l3jznkj 116 6 Crystal Crystal NNP cord-325328-3l3jznkj 116 7 structure structure NN cord-325328-3l3jznkj 116 8 of of IN cord-325328-3l3jznkj 116 9 a a DT cord-325328-3l3jznkj 116 10 phage phage NN cord-325328-3l3jznkj 116 11 Twort Twort NNP cord-325328-3l3jznkj 116 12 group group NN cord-325328-3l3jznkj 116 13 I -PRON- PRP cord-325328-3l3jznkj 116 14 ribozyme ribozyme NN cord-325328-3l3jznkj 116 15 - - HYPH cord-325328-3l3jznkj 116 16 product product NN cord-325328-3l3jznkj 116 17 complex complex NN cord-325328-3l3jznkj 116 18 Structure structure NN cord-325328-3l3jznkj 116 19 of of IN cord-325328-3l3jznkj 116 20 the the DT cord-325328-3l3jznkj 116 21 Tetrahymena Tetrahymena NNP cord-325328-3l3jznkj 116 22 ribozyme ribozyme NN cord-325328-3l3jznkj 116 23 : : : cord-325328-3l3jznkj 116 24 base base NN cord-325328-3l3jznkj 116 25 triple triple JJ cord-325328-3l3jznkj 116 26 sandwich sandwich NN cord-325328-3l3jznkj 116 27 and and CC cord-325328-3l3jznkj 116 28 metal metal NN cord-325328-3l3jznkj 116 29 ion ion NN cord-325328-3l3jznkj 116 30 at at IN cord-325328-3l3jznkj 116 31 the the DT cord-325328-3l3jznkj 116 32 active active JJ cord-325328-3l3jznkj 116 33 site site NN cord-325328-3l3jznkj 116 34 Crystal Crystal NNP cord-325328-3l3jznkj 116 35 structure structure NN cord-325328-3l3jznkj 116 36 of of IN cord-325328-3l3jznkj 116 37 the the DT cord-325328-3l3jznkj 116 38 specificity specificity NN cord-325328-3l3jznkj 116 39 domain domain NN cord-325328-3l3jznkj 116 40 of of IN cord-325328-3l3jznkj 116 41 ribonuclease ribonuclease NN cord-325328-3l3jznkj 116 42 P p NN cord-325328-3l3jznkj 116 43 Basis basis NN cord-325328-3l3jznkj 116 44 for for IN cord-325328-3l3jznkj 116 45 structural structural JJ cord-325328-3l3jznkj 116 46 diversity diversity NN cord-325328-3l3jznkj 116 47 in in IN cord-325328-3l3jznkj 116 48 homologous homologous JJ cord-325328-3l3jznkj 116 49 RNAs rna NNS cord-325328-3l3jznkj 117 1 The the DT cord-325328-3l3jznkj 117 2 crystal crystal JJ cord-325328-3l3jznkj 117 3 structure structure NN cord-325328-3l3jznkj 117 4 of of IN cord-325328-3l3jznkj 117 5 the the DT cord-325328-3l3jznkj 117 6 specificity specificity NN cord-325328-3l3jznkj 117 7 domain domain NN cord-325328-3l3jznkj 117 8 of of IN cord-325328-3l3jznkj 117 9 A a DT cord-325328-3l3jznkj 117 10 - - HYPH cord-325328-3l3jznkj 117 11 type type NN cord-325328-3l3jznkj 117 12 ribonuclease ribonuclease NN cord-325328-3l3jznkj 117 13 P p NN cord-325328-3l3jznkj 117 14 RNA RNA NNP cord-325328-3l3jznkj 117 15 from from IN cord-325328-3l3jznkj 117 16 Thermus Thermus NNP cord-325328-3l3jznkj 117 17 thermophilus thermophilus NNP cord-325328-3l3jznkj 117 18 was be VBD cord-325328-3l3jznkj 117 19 determined determine VBN cord-325328-3l3jznkj 117 20 . . . cord-325328-3l3jznkj 118 1 Comparison comparison NN cord-325328-3l3jznkj 118 2 of of IN cord-325328-3l3jznkj 118 3 the the DT cord-325328-3l3jznkj 118 4 Aand Aand NNP cord-325328-3l3jznkj 118 5 B b NN cord-325328-3l3jznkj 118 6 - - HYPH cord-325328-3l3jznkj 118 7 type type NN cord-325328-3l3jznkj 118 8 ribonuclease ribonuclease NN cord-325328-3l3jznkj 118 9 P p NN cord-325328-3l3jznkj 118 10 structures structure NNS cord-325328-3l3jznkj 118 11 shows show VBZ cord-325328-3l3jznkj 118 12 that that IN cord-325328-3l3jznkj 118 13 , , , cord-325328-3l3jznkj 118 14 although although IN cord-325328-3l3jznkj 118 15 the the DT cord-325328-3l3jznkj 118 16 secondary secondary JJ cord-325328-3l3jznkj 118 17 and and CC cord-325328-3l3jznkj 118 18 tertiary tertiary JJ cord-325328-3l3jznkj 118 19 structures structure NNS cord-325328-3l3jznkj 118 20 differ differ VBP cord-325328-3l3jznkj 118 21 Structural structural JJ cord-325328-3l3jznkj 118 22 basis basis NN cord-325328-3l3jznkj 118 23 for for IN cord-325328-3l3jznkj 118 24 discriminative discriminative JJ cord-325328-3l3jznkj 118 25 regulation regulation NN cord-325328-3l3jznkj 118 26 of of IN cord-325328-3l3jznkj 118 27 gene gene NN cord-325328-3l3jznkj 118 28 expression expression NN cord-325328-3l3jznkj 118 29 by by IN cord-325328-3l3jznkj 118 30 adenine adenine NN cord-325328-3l3jznkj 118 31 - - HYPH cord-325328-3l3jznkj 118 32 and and CC cord-325328-3l3jznkj 118 33 guanine guanine NN cord-325328-3l3jznkj 118 34 - - HYPH cord-325328-3l3jznkj 118 35 sensing sensing NN cord-325328-3l3jznkj 118 36 mRNAs mrna VBD cord-325328-3l3jznkj 118 37 Crystal Crystal NNP cord-325328-3l3jznkj 118 38 structures structure NNS cord-325328-3l3jznkj 118 39 of of IN cord-325328-3l3jznkj 118 40 guanine guanine NN cord-325328-3l3jznkj 118 41 - - HYPH cord-325328-3l3jznkj 118 42 and and CC cord-325328-3l3jznkj 118 43 adenine adenine NN cord-325328-3l3jznkj 118 44 - - HYPH cord-325328-3l3jznkj 118 45 responsive responsive JJ cord-325328-3l3jznkj 118 46 riboswitches riboswitche NNS cord-325328-3l3jznkj 118 47 are be VBP cord-325328-3l3jznkj 118 48 determined determine VBN cord-325328-3l3jznkj 118 49 . . . cord-325328-3l3jznkj 119 1 These these DT cord-325328-3l3jznkj 119 2 structures structure NNS cord-325328-3l3jznkj 119 3 illustrate illustrate VBP cord-325328-3l3jznkj 119 4 how how WRB cord-325328-3l3jznkj 119 5 the the DT cord-325328-3l3jznkj 119 6 RNAs rna NNS cord-325328-3l3jznkj 119 7 discriminate discriminate VBP cord-325328-3l3jznkj 119 8 between between IN cord-325328-3l3jznkj 119 9 adenine adenine NN cord-325328-3l3jznkj 119 10 and and CC cord-325328-3l3jznkj 119 11 guanine guanine NN cord-325328-3l3jznkj 119 12 , , , cord-325328-3l3jznkj 119 13 and and CC cord-325328-3l3jznkj 119 14 how how WRB cord-325328-3l3jznkj 119 15 they -PRON- PRP cord-325328-3l3jznkj 119 16 perform perform VBP cord-325328-3l3jznkj 119 17 their -PRON- PRP$ cord-325328-3l3jznkj 119 18 regulatory regulatory JJ cord-325328-3l3jznkj 119 19 function function NN cord-325328-3l3jznkj 119 20 Structure Structure NNP cord-325328-3l3jznkj 119 21 of of IN cord-325328-3l3jznkj 119 22 a a DT cord-325328-3l3jznkj 119 23 natural natural JJ cord-325328-3l3jznkj 119 24 guanine guanine NN cord-325328-3l3jznkj 119 25 - - HYPH cord-325328-3l3jznkj 119 26 responsive responsive JJ cord-325328-3l3jznkj 119 27 riboswitch riboswitch NN cord-325328-3l3jznkj 119 28 complexed complexe VBN cord-325328-3l3jznkj 119 29 with with IN cord-325328-3l3jznkj 119 30 the the DT cord-325328-3l3jznkj 119 31 metabolite metabolite JJ cord-325328-3l3jznkj 119 32 hypoxanthine hypoxanthine NN cord-325328-3l3jznkj 120 1 The the DT cord-325328-3l3jznkj 120 2 structure structure NN cord-325328-3l3jznkj 120 3 of of IN cord-325328-3l3jznkj 120 4 a a DT cord-325328-3l3jznkj 120 5 rigorously rigorously RB cord-325328-3l3jznkj 120 6 conserved conserve VBN cord-325328-3l3jznkj 120 7 RNA RNA NNP cord-325328-3l3jznkj 120 8 element element NN cord-325328-3l3jznkj 120 9 within within IN cord-325328-3l3jznkj 120 10 the the DT cord-325328-3l3jznkj 120 11 SARS SARS NNP cord-325328-3l3jznkj 120 12 virus virus NN cord-325328-3l3jznkj 120 13 genome genome NN cord-325328-3l3jznkj 121 1 The the DT cord-325328-3l3jznkj 121 2 crystal crystal JJ cord-325328-3l3jznkj 121 3 structure structure NN cord-325328-3l3jznkj 121 4 of of IN cord-325328-3l3jznkj 121 5 a a DT cord-325328-3l3jznkj 121 6 highly highly RB cord-325328-3l3jznkj 121 7 conserved conserve VBN cord-325328-3l3jznkj 121 8 fragment fragment NN cord-325328-3l3jznkj 121 9 of of IN cord-325328-3l3jznkj 121 10 the the DT cord-325328-3l3jznkj 121 11 SARS SARS NNP cord-325328-3l3jznkj 121 12 virus virus NN cord-325328-3l3jznkj 121 13 genome genome NN cord-325328-3l3jznkj 121 14 was be VBD cord-325328-3l3jznkj 121 15 determined determine VBN cord-325328-3l3jznkj 121 16 . . . cord-325328-3l3jznkj 122 1 The the DT cord-325328-3l3jznkj 122 2 structure structure NN cord-325328-3l3jznkj 122 3 shows show VBZ cord-325328-3l3jznkj 122 4 novel novel NN cord-325328-3l3jznkj 122 5 RNA RNA NNP cord-325328-3l3jznkj 122 6 secondary secondary JJ cord-325328-3l3jznkj 122 7 and and CC cord-325328-3l3jznkj 122 8 tertiary tertiary JJ cord-325328-3l3jznkj 122 9 structure structure NN cord-325328-3l3jznkj 122 10 elements element NNS cord-325328-3l3jznkj 122 11 Crystal Crystal NNP cord-325328-3l3jznkj 122 12 structure structure NN cord-325328-3l3jznkj 122 13 of of IN cord-325328-3l3jznkj 122 14 NF NF NNP cord-325328-3l3jznkj 122 15 - - HYPH cord-325328-3l3jznkj 122 16 kappaB kappaB NNP cord-325328-3l3jznkj 122 17 ( ( -LRB- cord-325328-3l3jznkj 122 18 p50)2 p50)2 RB cord-325328-3l3jznkj 122 19 complexed complexed JJ cord-325328-3l3jznkj 122 20 to to IN cord-325328-3l3jznkj 122 21 a a DT cord-325328-3l3jznkj 122 22 high high JJ cord-325328-3l3jznkj 122 23 - - HYPH cord-325328-3l3jznkj 122 24 affinity affinity NN cord-325328-3l3jznkj 122 25 RNA RNA NNP cord-325328-3l3jznkj 122 26 aptamer aptamer NNP cord-325328-3l3jznkj 122 27 Structure Structure NNP cord-325328-3l3jznkj 122 28 of of IN cord-325328-3l3jznkj 122 29 protein protein NN cord-325328-3l3jznkj 122 30 L7Ae L7Ae NNP cord-325328-3l3jznkj 122 31 bound bind VBN cord-325328-3l3jznkj 122 32 to to IN cord-325328-3l3jznkj 122 33 a a DT cord-325328-3l3jznkj 122 34 K k NN cord-325328-3l3jznkj 122 35 - - HYPH cord-325328-3l3jznkj 122 36 turn turn NN cord-325328-3l3jznkj 122 37 derived derive VBN cord-325328-3l3jznkj 122 38 from from IN cord-325328-3l3jznkj 122 39 an an DT cord-325328-3l3jznkj 122 40 archaeal archaeal JJ cord-325328-3l3jznkj 122 41 box box NN cord-325328-3l3jznkj 122 42 H H NNP cord-325328-3l3jznkj 122 43 / / SYM cord-325328-3l3jznkj 122 44 ACA ACA NNP cord-325328-3l3jznkj 123 1 sRNA sRNA VBG cord-325328-3l3jznkj 123 2 at at IN cord-325328-3l3jznkj 123 3 1.8Å 1.8å JJ cord-325328-3l3jznkj 123 4 resolution resolution NN cord-325328-3l3jznkj 124 1 A a DT cord-325328-3l3jznkj 124 2 conformational conformational JJ cord-325328-3l3jznkj 124 3 switch switch NN cord-325328-3l3jznkj 124 4 controls control NNS cord-325328-3l3jznkj 124 5 hepatitis hepatitis NNP cord-325328-3l3jznkj 124 6 delta delta NNP cord-325328-3l3jznkj 124 7 virus virus NN cord-325328-3l3jznkj 124 8 ribozyme ribozyme NNP cord-325328-3l3jznkj 124 9 catalysis catalysis NNP cord-325328-3l3jznkj 124 10 Crystal Crystal NNP cord-325328-3l3jznkj 124 11 structure structure NN cord-325328-3l3jznkj 124 12 of of IN cord-325328-3l3jznkj 124 13 a a DT cord-325328-3l3jznkj 124 14 hepatitis hepatitis NN cord-325328-3l3jznkj 124 15 delta delta NN cord-325328-3l3jznkj 124 16 virus virus NN cord-325328-3l3jznkj 124 17 ribozyme ribozyme NN cord-325328-3l3jznkj 124 18 High high JJ cord-325328-3l3jznkj 124 19 salt salt NN cord-325328-3l3jznkj 124 20 solution solution NN cord-325328-3l3jznkj 124 21 structure structure NN cord-325328-3l3jznkj 124 22 of of IN cord-325328-3l3jznkj 124 23 a a DT cord-325328-3l3jznkj 124 24 left left JJ cord-325328-3l3jznkj 124 25 - - HYPH cord-325328-3l3jznkj 124 26 handed handed JJ cord-325328-3l3jznkj 124 27 RNA RNA NNP cord-325328-3l3jznkj 124 28 double double JJ cord-325328-3l3jznkj 124 29 helix helix NN cord-325328-3l3jznkj 124 30 Betzel Betzel NNP cord-325328-3l3jznkj 124 31 C C NNP cord-325328-3l3jznkj 124 32 : : : cord-325328-3l3jznkj 125 1 First first RB cord-325328-3l3jznkj 125 2 look look NN cord-325328-3l3jznkj 125 3 at at IN cord-325328-3l3jznkj 125 4 RNA RNA NNP cord-325328-3l3jznkj 125 5 in in IN cord-325328-3l3jznkj 125 6 L l NN cord-325328-3l3jznkj 125 7 - - HYPH cord-325328-3l3jznkj 125 8 configuration configuration NN cord-325328-3l3jznkj 125 9 Alternative alternative JJ cord-325328-3l3jznkj 125 10 tertiary tertiary JJ cord-325328-3l3jznkj 125 11 structure structure NN cord-325328-3l3jznkj 125 12 of of IN cord-325328-3l3jznkj 125 13 tRNA tRNA NNP cord-325328-3l3jznkj 125 14 for for IN cord-325328-3l3jznkj 125 15 recognition recognition NN cord-325328-3l3jznkj 125 16 by by IN cord-325328-3l3jznkj 125 17 a a DT cord-325328-3l3jznkj 125 18 posttranscriptional posttranscriptional JJ cord-325328-3l3jznkj 125 19 modification modification NN cord-325328-3l3jznkj 125 20 enzyme enzyme NN cord-325328-3l3jznkj 125 21 tRNA tRNA NNP cord-325328-3l3jznkj 125 22 structure structure NN cord-325328-3l3jznkj 125 23 goes go VBZ cord-325328-3l3jznkj 125 24 from from IN cord-325328-3l3jznkj 125 25 L L NNP cord-325328-3l3jznkj 125 26 to to TO cord-325328-3l3jznkj 125 27 lambda lambda NN cord-325328-3l3jznkj 125 28 NCIR NCIR NNP cord-325328-3l3jznkj 125 29 : : : cord-325328-3l3jznkj 125 30 a a DT cord-325328-3l3jznkj 125 31 database database NN cord-325328-3l3jznkj 125 32 of of IN cord-325328-3l3jznkj 125 33 non non JJ cord-325328-3l3jznkj 125 34 - - JJ cord-325328-3l3jznkj 125 35 canonical canonical JJ cord-325328-3l3jznkj 125 36 interactions interaction NNS cord-325328-3l3jznkj 125 37 in in IN cord-325328-3l3jznkj 125 38 known know VBN cord-325328-3l3jznkj 125 39 RNA RNA NNP cord-325328-3l3jznkj 125 40 structures structure NNS cord-325328-3l3jznkj 125 41 Tools tool NNS cord-325328-3l3jznkj 125 42 for for IN cord-325328-3l3jznkj 125 43 the the DT cord-325328-3l3jznkj 125 44 automatic automatic JJ cord-325328-3l3jznkj 125 45 identification identification NN cord-325328-3l3jznkj 125 46 and and CC cord-325328-3l3jznkj 125 47 classification classification NN cord-325328-3l3jznkj 125 48 of of IN cord-325328-3l3jznkj 125 49 RNA RNA NNP cord-325328-3l3jznkj 125 50 base base NN cord-325328-3l3jznkj 125 51 pairs pair NNS cord-325328-3l3jznkj 125 52 RNA RNA NNP cord-325328-3l3jznkj 125 53 structure structure NN cord-325328-3l3jznkj 125 54 comparison comparison NN cord-325328-3l3jznkj 125 55 , , , cord-325328-3l3jznkj 125 56 motif motif NN cord-325328-3l3jznkj 125 57 search search NN cord-325328-3l3jznkj 125 58 and and CC cord-325328-3l3jznkj 125 59 discovery discovery NN cord-325328-3l3jznkj 125 60 using use VBG cord-325328-3l3jznkj 125 61 a a DT cord-325328-3l3jznkj 125 62 reduced reduce VBN cord-325328-3l3jznkj 125 63 representation representation NN cord-325328-3l3jznkj 125 64 of of IN cord-325328-3l3jznkj 125 65 RNA RNA NNP cord-325328-3l3jznkj 125 66 conformational conformational JJ cord-325328-3l3jznkj 125 67 space space NN cord-325328-3l3jznkj 126 1 The the DT cord-325328-3l3jznkj 126 2 identification identification NN cord-325328-3l3jznkj 126 3 of of IN cord-325328-3l3jznkj 126 4 novel novel NN cord-325328-3l3jznkj 126 5 RNA RNA NNP cord-325328-3l3jznkj 126 6 structural structural JJ cord-325328-3l3jznkj 126 7 motifs motif NNS cord-325328-3l3jznkj 126 8 using use VBG cord-325328-3l3jznkj 126 9 COMPADRES COMPADRES NNP cord-325328-3l3jznkj 126 10 : : : cord-325328-3l3jznkj 126 11 an an DT cord-325328-3l3jznkj 126 12 automated automated JJ cord-325328-3l3jznkj 126 13 approach approach NN cord-325328-3l3jznkj 126 14 to to IN cord-325328-3l3jznkj 126 15 structural structural JJ cord-325328-3l3jznkj 126 16 discovery discovery NN cord-325328-3l3jznkj 126 17 Motif Motif NNP cord-325328-3l3jznkj 126 18 prediction prediction NN cord-325328-3l3jznkj 126 19 in in IN cord-325328-3l3jznkj 126 20 ribosomal ribosomal JJ cord-325328-3l3jznkj 126 21 RNAs rna NNS cord-325328-3l3jznkj 126 22 . . . cord-325328-3l3jznkj 127 1 Lessons lesson NNS cord-325328-3l3jznkj 127 2 and and CC cord-325328-3l3jznkj 127 3 prospects prospect NNS cord-325328-3l3jznkj 127 4 for for IN cord-325328-3l3jznkj 127 5 automated automated JJ cord-325328-3l3jznkj 127 6 motif motif NN cord-325328-3l3jznkj 127 7 prediction prediction NN cord-325328-3l3jznkj 127 8 in in IN cord-325328-3l3jznkj 127 9 homologous homologous JJ cord-325328-3l3jznkj 127 10 RNA RNA NNP cord-325328-3l3jznkj 127 11 molecules molecule NNS cord-325328-3l3jznkj 127 12 SCOR SCOR NNP cord-325328-3l3jznkj 127 13 : : : cord-325328-3l3jznkj 128 1 Structural Structural NNP cord-325328-3l3jznkj 128 2 Classification Classification NNP cord-325328-3l3jznkj 128 3 of of IN cord-325328-3l3jznkj 128 4 RNA RNA NNP cord-325328-3l3jznkj 128 5 , , , cord-325328-3l3jznkj 128 6 version version NN cord-325328-3l3jznkj 128 7 2.0 2.0 CD cord-325328-3l3jznkj 128 8 Three three CD cord-325328-3l3jznkj 128 9 - - HYPH cord-325328-3l3jznkj 128 10 dimensional dimensional JJ cord-325328-3l3jznkj 128 11 motifs motif NNS cord-325328-3l3jznkj 128 12 from from IN cord-325328-3l3jznkj 128 13 the the DT cord-325328-3l3jznkj 128 14 SCOR SCOR NNP cord-325328-3l3jznkj 128 15 , , , cord-325328-3l3jznkj 128 16 structural structural JJ cord-325328-3l3jznkj 128 17 classification classification NN cord-325328-3l3jznkj 128 18 of of IN cord-325328-3l3jznkj 128 19 RNA RNA NNP cord-325328-3l3jznkj 128 20 database database NN cord-325328-3l3jznkj 128 21 : : : cord-325328-3l3jznkj 128 22 extruded extruded JJ cord-325328-3l3jznkj 128 23 strands strand NNS cord-325328-3l3jznkj 128 24 , , , cord-325328-3l3jznkj 128 25 base base NN cord-325328-3l3jznkj 128 26 triples triple NNS cord-325328-3l3jznkj 128 27 , , , cord-325328-3l3jznkj 128 28 tetraloops tetraloop NNS cord-325328-3l3jznkj 128 29 and and CC cord-325328-3l3jznkj 128 30 U U NNP cord-325328-3l3jznkj 128 31 - - HYPH cord-325328-3l3jznkj 128 32 turns turn NNS cord-325328-3l3jznkj 128 33 ) ) -RRB- cord-325328-3l3jznkj 128 34 is be VBZ cord-325328-3l3jznkj 128 35 a a DT cord-325328-3l3jznkj 128 36 compilation compilation NN cord-325328-3l3jznkj 128 37 and and CC cord-325328-3l3jznkj 128 38 classification classification NN cord-325328-3l3jznkj 128 39 of of IN cord-325328-3l3jznkj 128 40 RNA RNA NNP cord-325328-3l3jznkj 128 41 secondary secondary JJ cord-325328-3l3jznkj 128 42 and and CC cord-325328-3l3jznkj 128 43 tertiary tertiary JJ cord-325328-3l3jznkj 128 44 motifs motif NNS cord-325328-3l3jznkj 128 45 . . . cord-325328-3l3jznkj 129 1 Several several JJ cord-325328-3l3jznkj 129 2 new new JJ cord-325328-3l3jznkj 129 3 motifs motif NNS cord-325328-3l3jznkj 129 4 are be VBP cord-325328-3l3jznkj 129 5 identified identify VBN cord-325328-3l3jznkj 129 6 in in IN cord-325328-3l3jznkj 129 7 the the DT cord-325328-3l3jznkj 129 8 database database NN cord-325328-3l3jznkj 129 9 and and CC cord-325328-3l3jznkj 129 10 described describe VBN cord-325328-3l3jznkj 129 11 in in IN cord-325328-3l3jznkj 129 12 this this DT cord-325328-3l3jznkj 129 13 article article NN cord-325328-3l3jznkj 129 14 TectoRNA tectorna IN cord-325328-3l3jznkj 129 15 : : : cord-325328-3l3jznkj 129 16 modular modular NNP cord-325328-3l3jznkj 129 17 assembly assembly NN cord-325328-3l3jznkj 129 18 units unit NNS cord-325328-3l3jznkj 129 19 for for IN cord-325328-3l3jznkj 129 20 the the DT cord-325328-3l3jznkj 129 21 construction construction NN cord-325328-3l3jznkj 129 22 of of IN cord-325328-3l3jznkj 129 23 RNA RNA NNP cord-325328-3l3jznkj 129 24 nano nano NN cord-325328-3l3jznkj 129 25 - - HYPH cord-325328-3l3jznkj 129 26 objects object NNS cord-325328-3l3jznkj 129 27 Building Building NNP cord-325328-3l3jznkj 129 28 programmable programmable JJ cord-325328-3l3jznkj 129 29 jigsaw jigsaw NN cord-325328-3l3jznkj 129 30 puzzles puzzle NNS cord-325328-3l3jznkj 129 31 with with IN cord-325328-3l3jznkj 129 32 RNA RNA NNP cord-325328-3l3jznkj 129 33 Self Self NNP cord-325328-3l3jznkj 129 34 - - HYPH cord-325328-3l3jznkj 129 35 assembling assemble VBG cord-325328-3l3jznkj 129 36 RNA RNA NNP cord-325328-3l3jznkj 129 37 building building NN cord-325328-3l3jznkj 129 38 blocks block NNS cord-325328-3l3jznkj 129 39 were be VBD cord-325328-3l3jznkj 129 40 used use VBN cord-325328-3l3jznkj 129 41 to to TO cord-325328-3l3jznkj 129 42 generate generate VB cord-325328-3l3jznkj 129 43 defined define VBN cord-325328-3l3jznkj 129 44 structures structure NNS cord-325328-3l3jznkj 129 45 termed term VBD cord-325328-3l3jznkj 129 46 tectosquares tectosquare NNS cord-325328-3l3jznkj 129 47 . . . cord-325328-3l3jznkj 130 1 This this DT cord-325328-3l3jznkj 130 2 illustrates illustrate VBZ cord-325328-3l3jznkj 130 3 the the DT cord-325328-3l3jznkj 130 4 modularity modularity NN cord-325328-3l3jznkj 130 5 of of IN cord-325328-3l3jznkj 130 6 RNA RNA NNP cord-325328-3l3jznkj 130 7 , , , cord-325328-3l3jznkj 130 8 the the DT cord-325328-3l3jznkj 130 9 ability ability NN cord-325328-3l3jznkj 130 10 to to TO cord-325328-3l3jznkj 130 11 use use VB cord-325328-3l3jznkj 130 12 known know VBN cord-325328-3l3jznkj 130 13 structural structural JJ cord-325328-3l3jznkj 130 14 motifs motif NNS cord-325328-3l3jznkj 130 15 to to TO cord-325328-3l3jznkj 130 16 design design VB cord-325328-3l3jznkj 130 17 building building NN cord-325328-3l3jznkj 130 18 blocks block NNS cord-325328-3l3jznkj 130 19 and and CC cord-325328-3l3jznkj 130 20 the the DT cord-325328-3l3jznkj 130 21 potential potential NN cord-325328-3l3jznkj 130 22 of of IN cord-325328-3l3jznkj 130 23 RNA RNA NNP cord-325328-3l3jznkj 130 24 in in IN cord-325328-3l3jznkj 130 25 nanotechnology nanotechnology NN cord-325328-3l3jznkj 131 1 A a DT cord-325328-3l3jznkj 131 2 computational computational JJ cord-325328-3l3jznkj 131 3 approach approach NN cord-325328-3l3jznkj 131 4 to to TO cord-325328-3l3jznkj 131 5 identify identify VB cord-325328-3l3jznkj 131 6 genes gene NNS cord-325328-3l3jznkj 131 7 for for IN cord-325328-3l3jznkj 131 8 functional functional JJ cord-325328-3l3jznkj 131 9 RNAs rna NNS cord-325328-3l3jznkj 131 10 in in IN cord-325328-3l3jznkj 131 11 genomic genomic JJ cord-325328-3l3jznkj 131 12 sequences sequence NNS cord-325328-3l3jznkj 131 13 Mfold Mfold NNP cord-325328-3l3jznkj 131 14 web web NN cord-325328-3l3jznkj 131 15 server server NN cord-325328-3l3jznkj 131 16 for for IN cord-325328-3l3jznkj 131 17 nucleic nucleic JJ cord-325328-3l3jznkj 131 18 acid acid NN cord-325328-3l3jznkj 131 19 folding folding NN cord-325328-3l3jznkj 131 20 and and CC cord-325328-3l3jznkj 131 21 hybridization hybridization NN cord-325328-3l3jznkj 131 22 prediction prediction NN cord-325328-3l3jznkj 132 1 Vienna Vienna NNP cord-325328-3l3jznkj 132 2 RNA RNA NNP cord-325328-3l3jznkj 132 3 secondary secondary JJ cord-325328-3l3jznkj 132 4 structure structure NN cord-325328-3l3jznkj 132 5 server server NN cord-325328-3l3jznkj 132 6 Secondary secondary JJ cord-325328-3l3jznkj 132 7 structure structure NN cord-325328-3l3jznkj 132 8 prediction prediction NN cord-325328-3l3jznkj 132 9 for for IN cord-325328-3l3jznkj 132 10 aligned align VBN cord-325328-3l3jznkj 132 11 RNA RNA NNP cord-325328-3l3jznkj 132 12 sequences sequence NNS cord-325328-3l3jznkj 132 13 Sequence sequence NN cord-325328-3l3jznkj 132 14 and and CC cord-325328-3l3jznkj 132 15 structural structural JJ cord-325328-3l3jznkj 132 16 conservation conservation NN cord-325328-3l3jznkj 132 17 in in IN cord-325328-3l3jznkj 132 18 RNA RNA NNP cord-325328-3l3jznkj 132 19 ribose ribose NN cord-325328-3l3jznkj 132 20 zippers zipper NNS cord-325328-3l3jznkj 132 21 Paradigms Paradigms NNPS cord-325328-3l3jznkj 132 22 for for IN cord-325328-3l3jznkj 132 23 computational computational JJ cord-325328-3l3jznkj 132 24 nucleic nucleic JJ cord-325328-3l3jznkj 132 25 acid acid NN cord-325328-3l3jznkj 132 26 design design NN cord-325328-3l3jznkj 132 27 Kissing kiss VBG cord-325328-3l3jznkj 132 28 complex complex JJ cord-325328-3l3jznkj 132 29 RNAs rna NNS cord-325328-3l3jznkj 132 30 mediate mediate VBP cord-325328-3l3jznkj 132 31 interaction interaction NN cord-325328-3l3jznkj 132 32 between between IN cord-325328-3l3jznkj 132 33 the the DT cord-325328-3l3jznkj 132 34 Fragile Fragile NNP cord-325328-3l3jznkj 132 35 - - HYPH cord-325328-3l3jznkj 132 36 X x NN cord-325328-3l3jznkj 132 37 mental mental JJ cord-325328-3l3jznkj 132 38 retardation retardation NN cord-325328-3l3jznkj 132 39 protein protein NN cord-325328-3l3jznkj 132 40 KH2 KH2 NNP cord-325328-3l3jznkj 132 41 domain domain NN cord-325328-3l3jznkj 132 42 and and CC cord-325328-3l3jznkj 132 43 brain brain NN cord-325328-3l3jznkj 132 44 polyribosomes polyribosome NNS cord-325328-3l3jznkj 133 1 Lead lead VB cord-325328-3l3jznkj 133 2 toxicity toxicity NN cord-325328-3l3jznkj 133 3 through through IN cord-325328-3l3jznkj 133 4 the the DT cord-325328-3l3jznkj 133 5 leadzyme leadzyme NNP cord-325328-3l3jznkj 133 6 RNA RNA NNP cord-325328-3l3jznkj 133 7 structure structure NN cord-325328-3l3jznkj 133 8 of of IN cord-325328-3l3jznkj 133 9 trinucleotide trinucleotide NNP cord-325328-3l3jznkj 133 10 repeats repeat VBZ cord-325328-3l3jznkj 133 11 associated associate VBN cord-325328-3l3jznkj 133 12 with with IN cord-325328-3l3jznkj 133 13 human human JJ cord-325328-3l3jznkj 133 14 diseases disease NNS cord-325328-3l3jznkj 133 15 Molecular Molecular NNP cord-325328-3l3jznkj 133 16 architecture architecture NN cord-325328-3l3jznkj 133 17 of of IN cord-325328-3l3jznkj 133 18 CAG CAG NNP cord-325328-3l3jznkj 133 19 repeats repeat VBZ cord-325328-3l3jznkj 133 20 in in IN cord-325328-3l3jznkj 133 21 human human JJ cord-325328-3l3jznkj 133 22 disease disease NN cord-325328-3l3jznkj 133 23 related relate VBN cord-325328-3l3jznkj 133 24 transcripts transcript NNS cord-325328-3l3jznkj 134 1 The the DT cord-325328-3l3jznkj 134 2 author author NN cord-325328-3l3jznkj 134 3 acknowledges acknowledge VBZ cord-325328-3l3jznkj 134 4 Jasmin Jasmin NNP cord-325328-3l3jznkj 134 5 Yang Yang NNP cord-325328-3l3jznkj 134 6 of of IN cord-325328-3l3jznkj 134 7 the the DT cord-325328-3l3jznkj 134 8 NDB ndb NN cord-325328-3l3jznkj 134 9 , , , cord-325328-3l3jznkj 134 10 and and CC cord-325328-3l3jznkj 134 11 Donna Donna NNP cord-325328-3l3jznkj 134 12 Hendrix Hendrix NNP cord-325328-3l3jznkj 134 13 and and CC cord-325328-3l3jznkj 134 14 Elizabeth Elizabeth NNP cord-325328-3l3jznkj 134 15 Holbrook Holbrook NNP cord-325328-3l3jznkj 134 16 of of IN cord-325328-3l3jznkj 134 17 UC UC NNP cord-325328-3l3jznkj 134 18 Berkeley Berkeley NNP cord-325328-3l3jznkj 134 19 for for IN cord-325328-3l3jznkj 134 20 assistance assistance NN cord-325328-3l3jznkj 134 21 in in IN cord-325328-3l3jznkj 134 22 the the DT cord-325328-3l3jznkj 134 23 preparation preparation NN cord-325328-3l3jznkj 134 24 of of IN cord-325328-3l3jznkj 134 25 this this DT cord-325328-3l3jznkj 134 26 manuscript manuscript NN cord-325328-3l3jznkj 134 27 . . . cord-325328-3l3jznkj 135 1 SRH SRH NNP cord-325328-3l3jznkj 135 2 was be VBD cord-325328-3l3jznkj 135 3 supported support VBN cord-325328-3l3jznkj 135 4 by by IN cord-325328-3l3jznkj 135 5 National National NNP cord-325328-3l3jznkj 135 6 Institutes Institutes NNPS cord-325328-3l3jznkj 135 7 of of IN cord-325328-3l3jznkj 135 8 Health Health NNP cord-325328-3l3jznkj 135 9 grants grant VBZ cord-325328-3l3jznkj 135 10 1R01GM66199 1r01gm66199 CD cord-325328-3l3jznkj 135 11 and and CC cord-325328-3l3jznkj 135 12 1R01HG002665 1r01hg002665 CD cord-325328-3l3jznkj 135 13 . . .