id sid tid token lemma pos cord-313694-p2sgaypq 1 1 key key JJ cord-313694-p2sgaypq 1 2 : : : cord-313694-p2sgaypq 1 3 cord-313694-p2sgaypq cord-313694-p2sgaypq JJ cord-313694-p2sgaypq 1 4 authors author NNS cord-313694-p2sgaypq 1 5 : : : cord-313694-p2sgaypq 1 6 West West NNP cord-313694-p2sgaypq 1 7 , , , cord-313694-p2sgaypq 1 8 Christopher Christopher NNP cord-313694-p2sgaypq 1 9 M. M. NNP cord-313694-p2sgaypq 1 10 title title NN cord-313694-p2sgaypq 1 11 : : : cord-313694-p2sgaypq 1 12 Current current JJ cord-313694-p2sgaypq 1 13 ideas idea NNS cord-313694-p2sgaypq 1 14 on on IN cord-313694-p2sgaypq 1 15 the the DT cord-313694-p2sgaypq 1 16 significance significance NN cord-313694-p2sgaypq 1 17 of of IN cord-313694-p2sgaypq 1 18 protein protein NN cord-313694-p2sgaypq 1 19 glycosylation glycosylation NN cord-313694-p2sgaypq 1 20 date date NN cord-313694-p2sgaypq 1 21 : : : cord-313694-p2sgaypq 1 22 1986 1986 CD cord-313694-p2sgaypq 1 23 journal journal NN cord-313694-p2sgaypq 1 24 : : : cord-313694-p2sgaypq 1 25 Mol Mol NNP cord-313694-p2sgaypq 1 26 Cell Cell NNP cord-313694-p2sgaypq 1 27 Biochem Biochem NNP cord-313694-p2sgaypq 1 28 DOI DOI NNP cord-313694-p2sgaypq 1 29 : : : cord-313694-p2sgaypq 1 30 10.1007 10.1007 CD cord-313694-p2sgaypq 1 31 / / SYM cord-313694-p2sgaypq 1 32 bf00230632 bf00230632 NN cord-313694-p2sgaypq 1 33 sha sha NNP cord-313694-p2sgaypq 1 34 : : : cord-313694-p2sgaypq 2 1 f0503899aeb8a965c8e489a8b1ab724f2a4ef6ab f0503899aeb8a965c8e489a8b1ab724f2a4ef6ab NNP cord-313694-p2sgaypq 2 2 doc_id doc_id CD cord-313694-p2sgaypq 2 3 : : : cord-313694-p2sgaypq 2 4 313694 313694 CD cord-313694-p2sgaypq 2 5 cord_uid cord_uid NN cord-313694-p2sgaypq 2 6 : : : cord-313694-p2sgaypq 3 1 p2sgaypq p2sgaypq NNP cord-313694-p2sgaypq 3 2 Carbohydrate Carbohydrate NNP cord-313694-p2sgaypq 3 3 has have VBZ cord-313694-p2sgaypq 3 4 been be VBN cord-313694-p2sgaypq 3 5 removed remove VBN cord-313694-p2sgaypq 3 6 from from IN cord-313694-p2sgaypq 3 7 a a DT cord-313694-p2sgaypq 3 8 number number NN cord-313694-p2sgaypq 3 9 of of IN cord-313694-p2sgaypq 3 10 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 3 11 without without IN cord-313694-p2sgaypq 3 12 major major JJ cord-313694-p2sgaypq 3 13 effect effect NN cord-313694-p2sgaypq 3 14 on on IN cord-313694-p2sgaypq 3 15 the the DT cord-313694-p2sgaypq 3 16 structure structure NN cord-313694-p2sgaypq 3 17 or or CC cord-313694-p2sgaypq 3 18 enzyme enzyme NN cord-313694-p2sgaypq 3 19 activity activity NN cord-313694-p2sgaypq 3 20 of of IN cord-313694-p2sgaypq 3 21 the the DT cord-313694-p2sgaypq 3 22 protein protein NN cord-313694-p2sgaypq 3 23 . . . cord-313694-p2sgaypq 4 1 Thus thus RB cord-313694-p2sgaypq 4 2 carbohydrate carbohydrate NN cord-313694-p2sgaypq 4 3 has have VBZ cord-313694-p2sgaypq 4 4 been be VBN cord-313694-p2sgaypq 4 5 suggested suggest VBN cord-313694-p2sgaypq 4 6 to to TO cord-313694-p2sgaypq 4 7 underly underly VB cord-313694-p2sgaypq 4 8 a a DT cord-313694-p2sgaypq 4 9 non non JJ cord-313694-p2sgaypq 4 10 - - JJ cord-313694-p2sgaypq 4 11 primary primary JJ cord-313694-p2sgaypq 4 12 function function NN cord-313694-p2sgaypq 4 13 for for IN cord-313694-p2sgaypq 4 14 proteins protein NNS cord-313694-p2sgaypq 4 15 , , , cord-313694-p2sgaypq 4 16 such such JJ cord-313694-p2sgaypq 4 17 as as IN cord-313694-p2sgaypq 4 18 in in IN cord-313694-p2sgaypq 4 19 relatively relatively RB cord-313694-p2sgaypq 4 20 non non JJ cord-313694-p2sgaypq 4 21 - - JJ cord-313694-p2sgaypq 4 22 specific specific JJ cord-313694-p2sgaypq 4 23 interactions interaction NNS cord-313694-p2sgaypq 4 24 with with IN cord-313694-p2sgaypq 4 25 other other JJ cord-313694-p2sgaypq 4 26 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 4 27 or or CC cord-313694-p2sgaypq 4 28 macromolecules macromolecule NNS cord-313694-p2sgaypq 4 29 , , , cord-313694-p2sgaypq 4 30 stabilization stabilization NN cord-313694-p2sgaypq 4 31 of of IN cord-313694-p2sgaypq 4 32 protein protein NN cord-313694-p2sgaypq 4 33 conformation conformation NN cord-313694-p2sgaypq 4 34 , , , cord-313694-p2sgaypq 4 35 or or CC cord-313694-p2sgaypq 4 36 protection protection NN cord-313694-p2sgaypq 4 37 from from IN cord-313694-p2sgaypq 4 38 proteolysis proteolysis NN cord-313694-p2sgaypq 4 39 . . . cord-313694-p2sgaypq 5 1 This this DT cord-313694-p2sgaypq 5 2 non non JJ cord-313694-p2sgaypq 5 3 - - JJ cord-313694-p2sgaypq 5 4 specific specific JJ cord-313694-p2sgaypq 5 5 concept concept NN cord-313694-p2sgaypq 5 6 is be VBZ cord-313694-p2sgaypq 5 7 consistent consistent JJ cord-313694-p2sgaypq 5 8 with with IN cord-313694-p2sgaypq 5 9 both both CC cord-313694-p2sgaypq 5 10 the the DT cord-313694-p2sgaypq 5 11 general general JJ cord-313694-p2sgaypq 5 12 similarity similarity NN cord-313694-p2sgaypq 5 13 in in IN cord-313694-p2sgaypq 5 14 carbohydrate carbohydrate NN cord-313694-p2sgaypq 5 15 structure structure NN cord-313694-p2sgaypq 5 16 on on IN cord-313694-p2sgaypq 5 17 very very RB cord-313694-p2sgaypq 5 18 diverse diverse JJ cord-313694-p2sgaypq 5 19 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 5 20 and and CC cord-313694-p2sgaypq 5 21 the the DT cord-313694-p2sgaypq 5 22 frequent frequent JJ cord-313694-p2sgaypq 5 23 structural structural JJ cord-313694-p2sgaypq 5 24 microheterogeneity microheterogeneity NN cord-313694-p2sgaypq 5 25 of of IN cord-313694-p2sgaypq 5 26 carbohydrate carbohydrate NN cord-313694-p2sgaypq 5 27 chains chain NNS cord-313694-p2sgaypq 5 28 at at IN cord-313694-p2sgaypq 5 29 given give VBN cord-313694-p2sgaypq 5 30 sites site NNS cord-313694-p2sgaypq 5 31 . . . cord-313694-p2sgaypq 6 1 The the DT cord-313694-p2sgaypq 6 2 concept concept NN cord-313694-p2sgaypq 6 3 is be VBZ cord-313694-p2sgaypq 6 4 supported support VBN cord-313694-p2sgaypq 6 5 in in IN cord-313694-p2sgaypq 6 6 a a DT cord-313694-p2sgaypq 6 7 general general JJ cord-313694-p2sgaypq 6 8 sense sense NN cord-313694-p2sgaypq 6 9 by by IN cord-313694-p2sgaypq 6 10 the the DT cord-313694-p2sgaypq 6 11 viability viability NN cord-313694-p2sgaypq 6 12 of of IN cord-313694-p2sgaypq 6 13 cells cell NNS cord-313694-p2sgaypq 6 14 whose whose WP$ cord-313694-p2sgaypq 6 15 glycosylation glycosylation NN cord-313694-p2sgaypq 6 16 processes process NNS cord-313694-p2sgaypq 6 17 have have VBP cord-313694-p2sgaypq 6 18 been be VBN cord-313694-p2sgaypq 6 19 globally globally RB cord-313694-p2sgaypq 6 20 disrupted disrupt VBN cord-313694-p2sgaypq 6 21 by by IN cord-313694-p2sgaypq 6 22 mutation mutation NN cord-313694-p2sgaypq 6 23 or or CC cord-313694-p2sgaypq 6 24 pharmacological pharmacological JJ cord-313694-p2sgaypq 6 25 inhibitors inhibitor NNS cord-313694-p2sgaypq 6 26 . . . cord-313694-p2sgaypq 7 1 In in IN cord-313694-p2sgaypq 7 2 contrast contrast NN cord-313694-p2sgaypq 7 3 to to IN cord-313694-p2sgaypq 7 4 the the DT cord-313694-p2sgaypq 7 5 above above JJ cord-313694-p2sgaypq 7 6 observations observation NNS cord-313694-p2sgaypq 7 7 , , , cord-313694-p2sgaypq 7 8 other other JJ cord-313694-p2sgaypq 7 9 studies study NNS cord-313694-p2sgaypq 7 10 have have VBP cord-313694-p2sgaypq 7 11 revealed reveal VBN cord-313694-p2sgaypq 7 12 the the DT cord-313694-p2sgaypq 7 13 existence existence NN cord-313694-p2sgaypq 7 14 of of IN cord-313694-p2sgaypq 7 15 specific specific JJ cord-313694-p2sgaypq 7 16 , , , cord-313694-p2sgaypq 7 17 selective selective JJ cord-313694-p2sgaypq 7 18 receptors receptor NNS cord-313694-p2sgaypq 7 19 for for IN cord-313694-p2sgaypq 7 20 discrete discrete JJ cord-313694-p2sgaypq 7 21 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 7 22 structures structure NNS cord-313694-p2sgaypq 7 23 on on IN cord-313694-p2sgaypq 7 24 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 7 25 which which WDT cord-313694-p2sgaypq 7 26 seem seem VBP cord-313694-p2sgaypq 7 27 to to TO cord-313694-p2sgaypq 7 28 be be VB cord-313694-p2sgaypq 7 29 important important JJ cord-313694-p2sgaypq 7 30 for for IN cord-313694-p2sgaypq 7 31 compartmentalization compartmentalization NN cord-313694-p2sgaypq 7 32 of of IN cord-313694-p2sgaypq 7 33 the the DT cord-313694-p2sgaypq 7 34 glycoprotein glycoprotein NN cord-313694-p2sgaypq 7 35 , , , cord-313694-p2sgaypq 7 36 or or CC cord-313694-p2sgaypq 7 37 the the DT cord-313694-p2sgaypq 7 38 positioning positioning NN cord-313694-p2sgaypq 7 39 of of IN cord-313694-p2sgaypq 7 40 cells cell NNS cord-313694-p2sgaypq 7 41 on on IN cord-313694-p2sgaypq 7 42 which which WDT cord-313694-p2sgaypq 7 43 the the DT cord-313694-p2sgaypq 7 44 glycoprotein glycoprotein NN cord-313694-p2sgaypq 7 45 is be VBZ cord-313694-p2sgaypq 7 46 concentrated concentrated JJ cord-313694-p2sgaypq 7 47 . . . cord-313694-p2sgaypq 8 1 Sometimes sometimes RB cord-313694-p2sgaypq 8 2 multivalency multivalency NN cord-313694-p2sgaypq 8 3 in in IN cord-313694-p2sgaypq 8 4 the the DT cord-313694-p2sgaypq 8 5 carbohydrate carbohydrate NN cord-313694-p2sgaypq 8 6 - - HYPH cord-313694-p2sgaypq 8 7 receptor receptor NN cord-313694-p2sgaypq 8 8 interaction interaction NN cord-313694-p2sgaypq 8 9 is be VBZ cord-313694-p2sgaypq 8 10 crucial crucial JJ cord-313694-p2sgaypq 8 11 . . . cord-313694-p2sgaypq 9 1 There there EX cord-313694-p2sgaypq 9 2 are be VBP cord-313694-p2sgaypq 9 3 additional additional JJ cord-313694-p2sgaypq 9 4 possible possible JJ cord-313694-p2sgaypq 9 5 roles role NNS cord-313694-p2sgaypq 9 6 for for IN cord-313694-p2sgaypq 9 7 carbohydrate carbohydrate NN cord-313694-p2sgaypq 9 8 in in IN cord-313694-p2sgaypq 9 9 the the DT cord-313694-p2sgaypq 9 10 transduction transduction NN cord-313694-p2sgaypq 9 11 of of IN cord-313694-p2sgaypq 9 12 information information NN cord-313694-p2sgaypq 9 13 upon upon IN cord-313694-p2sgaypq 9 14 binding bind VBG cord-313694-p2sgaypq 9 15 to to IN cord-313694-p2sgaypq 9 16 a a DT cord-313694-p2sgaypq 9 17 receptor receptor NN cord-313694-p2sgaypq 9 18 . . . cord-313694-p2sgaypq 10 1 The the DT cord-313694-p2sgaypq 10 2 possibility possibility NN cord-313694-p2sgaypq 10 3 of of IN cord-313694-p2sgaypq 10 4 specific specific JJ cord-313694-p2sgaypq 10 5 roles role NNS cord-313694-p2sgaypq 10 6 for for IN cord-313694-p2sgaypq 10 7 carbohydrate carbohydrate NN cord-313694-p2sgaypq 10 8 is be VBZ cord-313694-p2sgaypq 10 9 supported support VBN cord-313694-p2sgaypq 10 10 by by IN cord-313694-p2sgaypq 10 11 the the DT cord-313694-p2sgaypq 10 12 existence existence NN cord-313694-p2sgaypq 10 13 of of IN cord-313694-p2sgaypq 10 14 numerous numerous JJ cord-313694-p2sgaypq 10 15 unique unique JJ cord-313694-p2sgaypq 10 16 carbohydrate carbohydrate NN cord-313694-p2sgaypq 10 17 structures structure NNS cord-313694-p2sgaypq 10 18 , , , cord-313694-p2sgaypq 10 19 many many JJ cord-313694-p2sgaypq 10 20 of of IN cord-313694-p2sgaypq 10 21 which which WDT cord-313694-p2sgaypq 10 22 have have VBP cord-313694-p2sgaypq 10 23 been be VBN cord-313694-p2sgaypq 10 24 detected detect VBN cord-313694-p2sgaypq 10 25 as as IN cord-313694-p2sgaypq 10 26 glycoantigens glycoantigen NNS cord-313694-p2sgaypq 10 27 by by IN cord-313694-p2sgaypq 10 28 monoclonal monoclonal JJ cord-313694-p2sgaypq 10 29 antibodies antibody NNS cord-313694-p2sgaypq 10 30 , , , cord-313694-p2sgaypq 10 31 with with IN cord-313694-p2sgaypq 10 32 unique unique JJ cord-313694-p2sgaypq 10 33 distributions distribution NNS cord-313694-p2sgaypq 10 34 in in IN cord-313694-p2sgaypq 10 35 developing develop VBG cord-313694-p2sgaypq 10 36 and and CC cord-313694-p2sgaypq 10 37 differentiated differentiated JJ cord-313694-p2sgaypq 10 38 cells cell NNS cord-313694-p2sgaypq 10 39 . . . cord-313694-p2sgaypq 11 1 This this DT cord-313694-p2sgaypq 11 2 article article NN cord-313694-p2sgaypq 11 3 attempts attempt VBZ cord-313694-p2sgaypq 11 4 to to TO cord-313694-p2sgaypq 11 5 summarize summarize VB cord-313694-p2sgaypq 11 6 and and CC cord-313694-p2sgaypq 11 7 rationalize rationalize VB cord-313694-p2sgaypq 11 8 the the DT cord-313694-p2sgaypq 11 9 contradictory contradictory JJ cord-313694-p2sgaypq 11 10 results result NNS cord-313694-p2sgaypq 11 11 . . . cord-313694-p2sgaypq 12 1 It -PRON- PRP cord-313694-p2sgaypq 12 2 appears appear VBZ cord-313694-p2sgaypq 12 3 that that IN cord-313694-p2sgaypq 12 4 in in IN cord-313694-p2sgaypq 12 5 general general JJ cord-313694-p2sgaypq 12 6 carbohydrate carbohydrate NN cord-313694-p2sgaypq 12 7 does do VBZ cord-313694-p2sgaypq 12 8 in in IN cord-313694-p2sgaypq 12 9 fact fact NN cord-313694-p2sgaypq 12 10 underlie underlie VB cord-313694-p2sgaypq 12 11 only only RB cord-313694-p2sgaypq 12 12 roles role NNS cord-313694-p2sgaypq 12 13 secondary secondary JJ cord-313694-p2sgaypq 12 14 to to IN cord-313694-p2sgaypq 12 15 a a DT cord-313694-p2sgaypq 12 16 protein protein NN cord-313694-p2sgaypq 12 17 's 's POS cord-313694-p2sgaypq 12 18 primary primary JJ cord-313694-p2sgaypq 12 19 function function NN cord-313694-p2sgaypq 12 20 . . . cord-313694-p2sgaypq 13 1 These these DT cord-313694-p2sgaypq 13 2 secondary secondary JJ cord-313694-p2sgaypq 13 3 roles role NNS cord-313694-p2sgaypq 13 4 are be VBP cord-313694-p2sgaypq 13 5 simple simple JJ cord-313694-p2sgaypq 13 6 non non JJ cord-313694-p2sgaypq 13 7 - - JJ cord-313694-p2sgaypq 13 8 specific specific JJ cord-313694-p2sgaypq 13 9 ones one NNS cord-313694-p2sgaypq 13 10 of of IN cord-313694-p2sgaypq 13 11 protection protection NN cord-313694-p2sgaypq 13 12 and and CC cord-313694-p2sgaypq 13 13 stabilization stabilization NN cord-313694-p2sgaypq 13 14 , , , cord-313694-p2sgaypq 13 15 but but CC cord-313694-p2sgaypq 13 16 often often RB cord-313694-p2sgaypq 13 17 also also RB cord-313694-p2sgaypq 13 18 satisfy satisfy VBP cord-313694-p2sgaypq 13 19 the the DT cord-313694-p2sgaypq 13 20 more more RBR cord-313694-p2sgaypq 13 21 sophisticated sophisticated JJ cord-313694-p2sgaypq 13 22 needs need NNS cord-313694-p2sgaypq 13 23 of of IN cord-313694-p2sgaypq 13 24 spatial spatial JJ cord-313694-p2sgaypq 13 25 position position NN cord-313694-p2sgaypq 13 26 control control NN cord-313694-p2sgaypq 13 27 and and CC cord-313694-p2sgaypq 13 28 compartmentalization compartmentalization NN cord-313694-p2sgaypq 13 29 in in IN cord-313694-p2sgaypq 13 30 multicellular multicellular JJ cord-313694-p2sgaypq 13 31 eukaryotic eukaryotic JJ cord-313694-p2sgaypq 13 32 organisms organism NNS cord-313694-p2sgaypq 13 33 . . . cord-313694-p2sgaypq 14 1 It -PRON- PRP cord-313694-p2sgaypq 14 2 is be VBZ cord-313694-p2sgaypq 14 3 suggested suggest VBN cord-313694-p2sgaypq 14 4 that that IN cord-313694-p2sgaypq 14 5 there there EX cord-313694-p2sgaypq 14 6 are be VBP cord-313694-p2sgaypq 14 7 advantages advantage NNS cord-313694-p2sgaypq 14 8 , , , cord-313694-p2sgaypq 14 9 evolutionarily evolutionarily RB cord-313694-p2sgaypq 14 10 speaking speak VBG cord-313694-p2sgaypq 14 11 , , , cord-313694-p2sgaypq 14 12 for for IN cord-313694-p2sgaypq 14 13 the the DT cord-313694-p2sgaypq 14 14 shared share VBN cord-313694-p2sgaypq 14 15 use use NN cord-313694-p2sgaypq 14 16 of of IN cord-313694-p2sgaypq 14 17 carbohydrate carbohydrate NN cord-313694-p2sgaypq 14 18 for for IN cord-313694-p2sgaypq 14 19 non non JJ cord-313694-p2sgaypq 14 20 - - JJ cord-313694-p2sgaypq 14 21 specific specific JJ cord-313694-p2sgaypq 14 22 roles role NNS cord-313694-p2sgaypq 14 23 and and CC cord-313694-p2sgaypq 14 24 for for IN cord-313694-p2sgaypq 14 25 specific specific JJ cord-313694-p2sgaypq 14 26 roles role NNS cord-313694-p2sgaypq 14 27 primarily primarily RB cord-313694-p2sgaypq 14 28 as as IN cord-313694-p2sgaypq 14 29 luxury luxury NN cord-313694-p2sgaypq 14 30 functions function NNS cord-313694-p2sgaypq 14 31 to to TO cord-313694-p2sgaypq 14 32 be be VB cord-313694-p2sgaypq 14 33 executed execute VBN cord-313694-p2sgaypq 14 34 during during IN cord-313694-p2sgaypq 14 35 the the DT cord-313694-p2sgaypq 14 36 processes process NNS cord-313694-p2sgaypq 14 37 of of IN cord-313694-p2sgaypq 14 38 cell cell NN cord-313694-p2sgaypq 14 39 differentiation differentiation NN cord-313694-p2sgaypq 14 40 and and CC cord-313694-p2sgaypq 14 41 morphogenesis morphogenesis NN cord-313694-p2sgaypq 14 42 . . . cord-313694-p2sgaypq 15 1 New new JJ cord-313694-p2sgaypq 15 2 information information NN cord-313694-p2sgaypq 15 3 about about IN cord-313694-p2sgaypq 15 4 the the DT cord-313694-p2sgaypq 15 5 significance significance NN cord-313694-p2sgaypq 15 6 of of IN cord-313694-p2sgaypq 15 7 protein protein NN cord-313694-p2sgaypq 15 8 glycosylation glycosylation NN cord-313694-p2sgaypq 15 9 is be VBZ cord-313694-p2sgaypq 15 10 rapidly rapidly RB cord-313694-p2sgaypq 15 11 accumulating accumulate VBG cord-313694-p2sgaypq 15 12 . . . cord-313694-p2sgaypq 16 1 This this DT cord-313694-p2sgaypq 16 2 can can MD cord-313694-p2sgaypq 16 3 be be VB cord-313694-p2sgaypq 16 4 attributed attribute VBN cord-313694-p2sgaypq 16 5 to to IN cord-313694-p2sgaypq 16 6 advancements advancement NNS cord-313694-p2sgaypq 16 7 in in IN cord-313694-p2sgaypq 16 8 methods method NNS cord-313694-p2sgaypq 16 9 to to TO cord-313694-p2sgaypq 16 10 detect detect VB cord-313694-p2sgaypq 16 11 and and CC cord-313694-p2sgaypq 16 12 isolate isolate VB cord-313694-p2sgaypq 16 13 new new JJ cord-313694-p2sgaypq 16 14 structures structure NNS cord-313694-p2sgaypq 16 15 , , , cord-313694-p2sgaypq 16 16 to to TO cord-313694-p2sgaypq 16 17 determine determine VB cord-313694-p2sgaypq 16 18 structure structure NN cord-313694-p2sgaypq 16 19 , , , cord-313694-p2sgaypq 16 20 and and CC cord-313694-p2sgaypq 16 21 to to TO cord-313694-p2sgaypq 16 22 modify modify VB cord-313694-p2sgaypq 16 23 carbohydrate carbohydrate NN cord-313694-p2sgaypq 16 24 structures structure NNS cord-313694-p2sgaypq 16 25 experimentally experimentally RB cord-313694-p2sgaypq 16 26 . . . cord-313694-p2sgaypq 17 1 Nevertheless nevertheless RB cord-313694-p2sgaypq 17 2 , , , cord-313694-p2sgaypq 17 3 the the DT cord-313694-p2sgaypq 17 4 field field NN cord-313694-p2sgaypq 17 5 continues continue VBZ cord-313694-p2sgaypq 17 6 to to TO cord-313694-p2sgaypq 17 7 experience experience VB cord-313694-p2sgaypq 17 8 profound profound JJ cord-313694-p2sgaypq 17 9 unrest unrest NN cord-313694-p2sgaypq 17 10 . . . cord-313694-p2sgaypq 18 1 Many many JJ cord-313694-p2sgaypq 18 2 studies study NNS cord-313694-p2sgaypq 18 3 have have VBP cord-313694-p2sgaypq 18 4 failed fail VBN cord-313694-p2sgaypq 18 5 to to TO cord-313694-p2sgaypq 18 6 un un NNP cord-313694-p2sgaypq 18 7 - - VB cord-313694-p2sgaypq 18 8 cover cover VB cord-313694-p2sgaypq 18 9 significant significant JJ cord-313694-p2sgaypq 18 10 cellular cellular JJ cord-313694-p2sgaypq 18 11 or or CC cord-313694-p2sgaypq 18 12 molecular molecular JJ cord-313694-p2sgaypq 18 13 consequences consequence NNS cord-313694-p2sgaypq 18 14 for for IN cord-313694-p2sgaypq 18 15 dramatic dramatic JJ cord-313694-p2sgaypq 18 16 changes change NNS cord-313694-p2sgaypq 18 17 in in IN cord-313694-p2sgaypq 18 18 carbohydrate carbohydrate NN cord-313694-p2sgaypq 18 19 structures structure NNS cord-313694-p2sgaypq 18 20 . . . cord-313694-p2sgaypq 19 1 Other other JJ cord-313694-p2sgaypq 19 2 studies study NNS cord-313694-p2sgaypq 19 3 have have VBP cord-313694-p2sgaypq 19 4 pointed point VBN cord-313694-p2sgaypq 19 5 to to IN cord-313694-p2sgaypq 19 6 isolated isolate VBN cord-313694-p2sgaypq 19 7 specific specific JJ cord-313694-p2sgaypq 19 8 roles role NNS cord-313694-p2sgaypq 19 9 but but CC cord-313694-p2sgaypq 19 10 no no DT cord-313694-p2sgaypq 19 11 sweeping sweeping JJ cord-313694-p2sgaypq 19 12 generalizations generalization NNS cord-313694-p2sgaypq 19 13 of of IN cord-313694-p2sgaypq 19 14 function function NN cord-313694-p2sgaypq 19 15 have have VBP cord-313694-p2sgaypq 19 16 been be VBN cord-313694-p2sgaypq 19 17 possible possible JJ cord-313694-p2sgaypq 19 18 . . . cord-313694-p2sgaypq 20 1 Interpreters interpreter NNS cord-313694-p2sgaypq 20 2 of of IN cord-313694-p2sgaypq 20 3 the the DT cord-313694-p2sgaypq 20 4 former former JJ cord-313694-p2sgaypq 20 5 studies study NNS cord-313694-p2sgaypq 20 6 would would MD cord-313694-p2sgaypq 20 7 attribute attribute VB cord-313694-p2sgaypq 20 8 apparent apparent JJ cord-313694-p2sgaypq 20 9 specific specific JJ cord-313694-p2sgaypq 20 10 effects effect NNS cord-313694-p2sgaypq 20 11 to to IN cord-313694-p2sgaypq 20 12 secondary secondary JJ cord-313694-p2sgaypq 20 13 consequences consequence NNS cord-313694-p2sgaypq 20 14 of of IN cord-313694-p2sgaypq 20 15 changes change NNS cord-313694-p2sgaypq 20 16 in in IN cord-313694-p2sgaypq 20 17 carbohydrate carbohydrate NN cord-313694-p2sgaypq 20 18 on on IN cord-313694-p2sgaypq 20 19 protein protein NN cord-313694-p2sgaypq 20 20 structure structure NN cord-313694-p2sgaypq 20 21 . . . cord-313694-p2sgaypq 21 1 Interpreters interpreter NNS cord-313694-p2sgaypq 21 2 of of IN cord-313694-p2sgaypq 21 3 the the DT cord-313694-p2sgaypq 21 4 latter latter JJ cord-313694-p2sgaypq 21 5 studies study NNS cord-313694-p2sgaypq 21 6 would would MD cord-313694-p2sgaypq 21 7 argue argue VB cord-313694-p2sgaypq 21 8 that that IN cord-313694-p2sgaypq 21 9 the the DT cord-313694-p2sgaypq 21 10 former former JJ cord-313694-p2sgaypq 21 11 studies study NNS cord-313694-p2sgaypq 21 12 simply simply RB cord-313694-p2sgaypq 21 13 failed fail VBD cord-313694-p2sgaypq 21 14 to to TO cord-313694-p2sgaypq 21 15 ask ask VB cord-313694-p2sgaypq 21 16 the the DT cord-313694-p2sgaypq 21 17 right right JJ cord-313694-p2sgaypq 21 18 questions question NNS cord-313694-p2sgaypq 21 19 of of IN cord-313694-p2sgaypq 21 20 function function NN cord-313694-p2sgaypq 21 21 . . . cord-313694-p2sgaypq 22 1 It -PRON- PRP cord-313694-p2sgaypq 22 2 is be VBZ cord-313694-p2sgaypq 22 3 clear clear JJ cord-313694-p2sgaypq 22 4 that that IN cord-313694-p2sgaypq 22 5 there there EX cord-313694-p2sgaypq 22 6 is be VBZ cord-313694-p2sgaypq 22 7 much much JJ cord-313694-p2sgaypq 22 8 to to TO cord-313694-p2sgaypq 22 9 be be VB cord-313694-p2sgaypq 22 10 done do VBN cord-313694-p2sgaypq 22 11 to to TO cord-313694-p2sgaypq 22 12 extend extend VB cord-313694-p2sgaypq 22 13 our -PRON- PRP$ cord-313694-p2sgaypq 22 14 knowledge knowledge NN cord-313694-p2sgaypq 22 15 for for IN cord-313694-p2sgaypq 22 16 this this DT cord-313694-p2sgaypq 22 17 particular particular JJ cord-313694-p2sgaypq 22 18 type type NN cord-313694-p2sgaypq 22 19 of of IN cord-313694-p2sgaypq 22 20 posttranslational posttranslational JJ cord-313694-p2sgaypq 22 21 modification modification NN cord-313694-p2sgaypq 22 22 . . . cord-313694-p2sgaypq 23 1 The the DT cord-313694-p2sgaypq 23 2 purpose purpose NN cord-313694-p2sgaypq 23 3 of of IN cord-313694-p2sgaypq 23 4 this this DT cord-313694-p2sgaypq 23 5 article article NN cord-313694-p2sgaypq 23 6 is be VBZ cord-313694-p2sgaypq 23 7 to to TO cord-313694-p2sgaypq 23 8 outline outline VB cord-313694-p2sgaypq 23 9 the the DT cord-313694-p2sgaypq 23 10 scope scope NN cord-313694-p2sgaypq 23 11 of of IN cord-313694-p2sgaypq 23 12 investigations investigation NNS cord-313694-p2sgaypq 23 13 presently presently RB cord-313694-p2sgaypq 23 14 being be VBG cord-313694-p2sgaypq 23 15 carried carry VBN cord-313694-p2sgaypq 23 16 out out RP cord-313694-p2sgaypq 23 17 in in IN cord-313694-p2sgaypq 23 18 this this DT cord-313694-p2sgaypq 23 19 subject subject JJ cord-313694-p2sgaypq 23 20 area area NN cord-313694-p2sgaypq 23 21 and and CC cord-313694-p2sgaypq 23 22 to to TO cord-313694-p2sgaypq 23 23 generalize generalize VB cord-313694-p2sgaypq 23 24 the the DT cord-313694-p2sgaypq 23 25 possible possible JJ cord-313694-p2sgaypq 23 26 significance significance NN cord-313694-p2sgaypq 23 27 of of IN cord-313694-p2sgaypq 23 28 these these DT cord-313694-p2sgaypq 23 29 new new JJ cord-313694-p2sgaypq 23 30 findings finding NNS cord-313694-p2sgaypq 23 31 . . . cord-313694-p2sgaypq 24 1 In in IN cord-313694-p2sgaypq 24 2 particular particular JJ cord-313694-p2sgaypq 24 3 , , , cord-313694-p2sgaypq 24 4 this this DT cord-313694-p2sgaypq 24 5 article article NN cord-313694-p2sgaypq 24 6 will will MD cord-313694-p2sgaypq 24 7 attempt attempt VB cord-313694-p2sgaypq 24 8 to to TO cord-313694-p2sgaypq 24 9 compare compare VB cord-313694-p2sgaypq 24 10 and and CC cord-313694-p2sgaypq 24 11 contrast contrast VB cord-313694-p2sgaypq 24 12 the the DT cord-313694-p2sgaypq 24 13 two two CD cord-313694-p2sgaypq 24 14 prevailing prevail VBG cord-313694-p2sgaypq 24 15 views view NNS cord-313694-p2sgaypq 24 16 in in IN cord-313694-p2sgaypq 24 17 the the DT cord-313694-p2sgaypq 24 18 field field NN cord-313694-p2sgaypq 24 19 . . . cord-313694-p2sgaypq 25 1 As as IN cord-313694-p2sgaypq 25 2 intimated intimate VBN cord-313694-p2sgaypq 25 3 above above RB cord-313694-p2sgaypq 25 4 , , , cord-313694-p2sgaypq 25 5 one one CD cord-313694-p2sgaypq 25 6 view view NN cord-313694-p2sgaypq 25 7 is be VBZ cord-313694-p2sgaypq 25 8 that that IN cord-313694-p2sgaypq 25 9 glycosylation glycosylation NN cord-313694-p2sgaypq 25 10 plays play VBZ cord-313694-p2sgaypq 25 11 a a DT cord-313694-p2sgaypq 25 12 relatively relatively RB cord-313694-p2sgaypq 25 13 non non JJ cord-313694-p2sgaypq 25 14 - - JJ cord-313694-p2sgaypq 25 15 specific specific JJ cord-313694-p2sgaypq 25 16 role role NN cord-313694-p2sgaypq 25 17 in in IN cord-313694-p2sgaypq 25 18 maintaining maintain VBG cord-313694-p2sgaypq 25 19 and and CC cord-313694-p2sgaypq 25 20 preserving preserve VBG cord-313694-p2sgaypq 25 21 polypeptide polypeptide NN cord-313694-p2sgaypq 25 22 function function NN cord-313694-p2sgaypq 25 23 . . . cord-313694-p2sgaypq 26 1 The the DT cord-313694-p2sgaypq 26 2 alternate alternate JJ cord-313694-p2sgaypq 26 3 view view NN cord-313694-p2sgaypq 26 4 is be VBZ cord-313694-p2sgaypq 26 5 that that IN cord-313694-p2sgaypq 26 6 carbohydrate carbohydrate NN cord-313694-p2sgaypq 26 7 structures structure NNS cord-313694-p2sgaypq 26 8 participate participate VBP cord-313694-p2sgaypq 26 9 in in IN cord-313694-p2sgaypq 26 10 numerous numerous JJ cord-313694-p2sgaypq 26 11 specific specific JJ cord-313694-p2sgaypq 26 12 interactions interaction NNS cord-313694-p2sgaypq 26 13 with with IN cord-313694-p2sgaypq 26 14 discrete discrete JJ cord-313694-p2sgaypq 26 15 protein protein NN cord-313694-p2sgaypq 26 16 receptors receptor NNS cord-313694-p2sgaypq 26 17 , , , cord-313694-p2sgaypq 26 18 and and CC cord-313694-p2sgaypq 26 19 that that IN cord-313694-p2sgaypq 26 20 these these DT cord-313694-p2sgaypq 26 21 interactions interaction NNS cord-313694-p2sgaypq 26 22 lead lead VBP cord-313694-p2sgaypq 26 23 to to IN cord-313694-p2sgaypq 26 24 predictable predictable JJ cord-313694-p2sgaypq 26 25 modifications modification NNS cord-313694-p2sgaypq 26 26 in in IN cord-313694-p2sgaypq 26 27 the the DT cord-313694-p2sgaypq 26 28 localization localization NN cord-313694-p2sgaypq 26 29 or or CC cord-313694-p2sgaypq 26 30 activity activity NN cord-313694-p2sgaypq 26 31 of of IN cord-313694-p2sgaypq 26 32 the the DT cord-313694-p2sgaypq 26 33 glycoprotein glycoprotein NN cord-313694-p2sgaypq 26 34 . . . cord-313694-p2sgaypq 27 1 These these DT cord-313694-p2sgaypq 27 2 opposing oppose VBG cord-313694-p2sgaypq 27 3 views view NNS cord-313694-p2sgaypq 27 4 will will MD cord-313694-p2sgaypq 27 5 be be VB cord-313694-p2sgaypq 27 6 simply simply RB cord-313694-p2sgaypq 27 7 referred refer VBN cord-313694-p2sgaypq 27 8 to to IN cord-313694-p2sgaypq 27 9 as as IN cord-313694-p2sgaypq 27 10 the the DT cord-313694-p2sgaypq 27 11 non non JJ cord-313694-p2sgaypq 27 12 - - JJ cord-313694-p2sgaypq 27 13 specific specific JJ cord-313694-p2sgaypq 27 14 and and CC cord-313694-p2sgaypq 27 15 specific specific JJ cord-313694-p2sgaypq 27 16 models model NNS cord-313694-p2sgaypq 27 17 . . . cord-313694-p2sgaypq 28 1 The the DT cord-313694-p2sgaypq 28 2 importance importance NN cord-313694-p2sgaypq 28 3 of of IN cord-313694-p2sgaypq 28 4 this this DT cord-313694-p2sgaypq 28 5 issue issue NN cord-313694-p2sgaypq 28 6 is be VBZ cord-313694-p2sgaypq 28 7 dramatized dramatize VBN cord-313694-p2sgaypq 28 8 by by IN cord-313694-p2sgaypq 28 9 the the DT cord-313694-p2sgaypq 28 10 fact fact NN cord-313694-p2sgaypq 28 11 that that IN cord-313694-p2sgaypq 28 12 nearly nearly RB cord-313694-p2sgaypq 28 13 all all DT cord-313694-p2sgaypq 28 14 secretory secretory JJ cord-313694-p2sgaypq 28 15 , , , cord-313694-p2sgaypq 28 16 extracellular extracellular JJ cord-313694-p2sgaypq 28 17 matrix matrix NN cord-313694-p2sgaypq 28 18 , , , cord-313694-p2sgaypq 28 19 cell cell NN cord-313694-p2sgaypq 28 20 surface surface NN cord-313694-p2sgaypq 28 21 and and CC cord-313694-p2sgaypq 28 22 lysosomal lysosomal JJ cord-313694-p2sgaypq 28 23 proteins protein NNS cord-313694-p2sgaypq 28 24 are be VBP cord-313694-p2sgaypq 28 25 glycosylated glycosylate VBN cord-313694-p2sgaypq 28 26 . . . cord-313694-p2sgaypq 29 1 There there EX cord-313694-p2sgaypq 29 2 are be VBP cord-313694-p2sgaypq 29 3 many many JJ cord-313694-p2sgaypq 29 4 published publish VBN cord-313694-p2sgaypq 29 5 comprehensive comprehensive JJ cord-313694-p2sgaypq 29 6 reviews review NNS cord-313694-p2sgaypq 29 7 on on IN cord-313694-p2sgaypq 29 8 aspects aspect NNS cord-313694-p2sgaypq 29 9 of of IN cord-313694-p2sgaypq 29 10 this this DT cord-313694-p2sgaypq 29 11 subject subject NN cord-313694-p2sgaypq 29 12 ( ( -LRB- cord-313694-p2sgaypq 29 13 1 1 CD cord-313694-p2sgaypq 29 14 - - SYM cord-313694-p2sgaypq 29 15 3 3 CD cord-313694-p2sgaypq 29 16 , , , cord-313694-p2sgaypq 29 17 14 14 CD cord-313694-p2sgaypq 29 18 , , , cord-313694-p2sgaypq 29 19 20 20 CD cord-313694-p2sgaypq 29 20 , , , cord-313694-p2sgaypq 29 21 43 43 CD cord-313694-p2sgaypq 29 22 , , , cord-313694-p2sgaypq 29 23 105 105 CD cord-313694-p2sgaypq 29 24 , , , cord-313694-p2sgaypq 29 25 110 110 CD cord-313694-p2sgaypq 29 26 , , , cord-313694-p2sgaypq 29 27 115 115 CD cord-313694-p2sgaypq 29 28 , , , cord-313694-p2sgaypq 29 29 130 130 CD cord-313694-p2sgaypq 29 30 , , , cord-313694-p2sgaypq 29 31 175 175 CD cord-313694-p2sgaypq 29 32 ) ) -RRB- cord-313694-p2sgaypq 29 33 and and CC cord-313694-p2sgaypq 29 34 the the DT cord-313694-p2sgaypq 29 35 reader reader NN cord-313694-p2sgaypq 29 36 is be VBZ cord-313694-p2sgaypq 29 37 referred refer VBN cord-313694-p2sgaypq 29 38 to to IN cord-313694-p2sgaypq 29 39 these these DT cord-313694-p2sgaypq 29 40 for for IN cord-313694-p2sgaypq 29 41 more more RBR cord-313694-p2sgaypq 29 42 detailed detailed JJ cord-313694-p2sgaypq 29 43 summaries summary NNS cord-313694-p2sgaypq 29 44 and and CC cord-313694-p2sgaypq 29 45 documentation documentation NN cord-313694-p2sgaypq 29 46 . . . cord-313694-p2sgaypq 30 1 Since since IN cord-313694-p2sgaypq 30 2 this this DT cord-313694-p2sgaypq 30 3 article article NN cord-313694-p2sgaypq 30 4 will will MD cord-313694-p2sgaypq 30 5 in in IN cord-313694-p2sgaypq 30 6 part part NN cord-313694-p2sgaypq 30 7 serve serve VB cord-313694-p2sgaypq 30 8 as as IN cord-313694-p2sgaypq 30 9 an an DT cord-313694-p2sgaypq 30 10 introduction introduction NN cord-313694-p2sgaypq 30 11 and and CC cord-313694-p2sgaypq 30 12 a a DT cord-313694-p2sgaypq 30 13 background background NN cord-313694-p2sgaypq 30 14 to to IN cord-313694-p2sgaypq 30 15 the the DT cord-313694-p2sgaypq 30 16 others other NNS cord-313694-p2sgaypq 30 17 in in IN cord-313694-p2sgaypq 30 18 this this DT cord-313694-p2sgaypq 30 19 volume volume NN cord-313694-p2sgaypq 30 20 , , , cord-313694-p2sgaypq 30 21 an an DT cord-313694-p2sgaypq 30 22 overview overview NN cord-313694-p2sgaypq 30 23 of of IN cord-313694-p2sgaypq 30 24 general general JJ cord-313694-p2sgaypq 30 25 features feature NNS cord-313694-p2sgaypq 30 26 of of IN cord-313694-p2sgaypq 30 27 the the DT cord-313694-p2sgaypq 30 28 glycosylation glycosylation NN cord-313694-p2sgaypq 30 29 process process NN cord-313694-p2sgaypq 30 30 has have VBZ cord-313694-p2sgaypq 30 31 been be VBN cord-313694-p2sgaypq 30 32 provided provide VBN cord-313694-p2sgaypq 30 33 to to TO cord-313694-p2sgaypq 30 34 precede precede VB cord-313694-p2sgaypq 30 35 the the DT cord-313694-p2sgaypq 30 36 summary summary NN cord-313694-p2sgaypq 30 37 of of IN cord-313694-p2sgaypq 30 38 existing exist VBG cord-313694-p2sgaypq 30 39 and and CC cord-313694-p2sgaypq 30 40 new new JJ cord-313694-p2sgaypq 30 41 ideas idea NNS cord-313694-p2sgaypq 30 42 in in IN cord-313694-p2sgaypq 30 43 the the DT cord-313694-p2sgaypq 30 44 field field NN cord-313694-p2sgaypq 30 45 which which WDT cord-313694-p2sgaypq 30 46 follows follow VBZ cord-313694-p2sgaypq 30 47 . . . cord-313694-p2sgaypq 31 1 Oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 31 2 linked link VBN cord-313694-p2sgaypq 31 3 to to IN cord-313694-p2sgaypq 31 4 asparagine asparagine NN cord-313694-p2sgaypq 31 5 occur occur VBP cord-313694-p2sgaypq 31 6 in in IN cord-313694-p2sgaypq 31 7 cellular cellular JJ cord-313694-p2sgaypq 31 8 slime slime NN cord-313694-p2sgaypq 31 9 molds mold NNS cord-313694-p2sgaypq 31 10 , , , cord-313694-p2sgaypq 31 11 yeast yeast NN cord-313694-p2sgaypq 31 12 , , , cord-313694-p2sgaypq 31 13 higher high JJR cord-313694-p2sgaypq 31 14 plants plant NNS cord-313694-p2sgaypq 31 15 , , , cord-313694-p2sgaypq 31 16 insects insect NNS cord-313694-p2sgaypq 31 17 , , , cord-313694-p2sgaypq 31 18 and and CC cord-313694-p2sgaypq 31 19 humans human NNS cord-313694-p2sgaypq 31 20 , , , cord-313694-p2sgaypq 31 21 and and CC cord-313694-p2sgaypq 31 22 several several JJ cord-313694-p2sgaypq 31 23 essential essential JJ cord-313694-p2sgaypq 31 24 features feature NNS cord-313694-p2sgaypq 31 25 of of IN cord-313694-p2sgaypq 31 26 these these DT cord-313694-p2sgaypq 31 27 structures structure NNS cord-313694-p2sgaypq 31 28 are be VBP cord-313694-p2sgaypq 31 29 highly highly RB cord-313694-p2sgaypq 31 30 conserved conserve VBN cord-313694-p2sgaypq 31 31 throughout throughout IN cord-313694-p2sgaypq 31 32 this this DT cord-313694-p2sgaypq 31 33 phylogenetic phylogenetic JJ cord-313694-p2sgaypq 31 34 range range NN cord-313694-p2sgaypq 31 35 ( ( -LRB- cord-313694-p2sgaypq 31 36 14 14 CD cord-313694-p2sgaypq 31 37 ) ) -RRB- cord-313694-p2sgaypq 31 38 . . . cord-313694-p2sgaypq 32 1 Typically typically RB cord-313694-p2sgaypq 32 2 though though IN cord-313694-p2sgaypq 32 3 not not RB cord-313694-p2sgaypq 32 4 invariably invariably RB cord-313694-p2sgaypq 32 5 , , , cord-313694-p2sgaypq 32 6 a a DT cord-313694-p2sgaypq 32 7 Glc3Man9GlcNAc2 Glc3Man9GlcNAc2 NNS cord-313694-p2sgaypq 32 8 structure structure NN cord-313694-p2sgaypq 32 9 is be VBZ cord-313694-p2sgaypq 32 10 synthesized synthesize VBN cord-313694-p2sgaypq 32 11 on on IN cord-313694-p2sgaypq 32 12 a a DT cord-313694-p2sgaypq 32 13 polyisoprenoid polyisoprenoid JJ cord-313694-p2sgaypq 32 14 derivative derivative NN cord-313694-p2sgaypq 32 15 ( ( -LRB- cord-313694-p2sgaypq 32 16 dolichol dolichol JJ cord-313694-p2sgaypq 32 17 - - HYPH cord-313694-p2sgaypq 32 18 P p NN cord-313694-p2sgaypq 32 19 - - HYPH cord-313694-p2sgaypq 32 20 P p NN cord-313694-p2sgaypq 32 21 ) ) -RRB- cord-313694-p2sgaypq 32 22 and and CC cord-313694-p2sgaypq 32 23 transferred transfer VBN cord-313694-p2sgaypq 32 24 en en IN cord-313694-p2sgaypq 32 25 bloc bloc NN cord-313694-p2sgaypq 32 26 to to IN cord-313694-p2sgaypq 32 27 asparagine asparagine NN cord-313694-p2sgaypq 32 28 residues residue NNS cord-313694-p2sgaypq 32 29 on on IN cord-313694-p2sgaypq 32 30 polypeptide polypeptide NN cord-313694-p2sgaypq 32 31 acceptors acceptor NNS cord-313694-p2sgaypq 32 32 forming form VBG cord-313694-p2sgaypq 32 33 an an DT cord-313694-p2sgaypq 32 34 N n CD cord-313694-p2sgaypq 32 35 - - HYPH cord-313694-p2sgaypq 32 36 glycosidic glycosidic NN cord-313694-p2sgaypq 32 37 linkage linkage NN cord-313694-p2sgaypq 32 38 ( ( -LRB- cord-313694-p2sgaypq 32 39 hence hence RB cord-313694-p2sgaypq 32 40 N n NN cord-313694-p2sgaypq 32 41 - - HYPH cord-313694-p2sgaypq 32 42 linked link VBN cord-313694-p2sgaypq 32 43 ) ) -RRB- cord-313694-p2sgaypq 32 44 . . . cord-313694-p2sgaypq 33 1 The the DT cord-313694-p2sgaypq 33 2 three three CD cord-313694-p2sgaypq 33 3 Glcs Glcs NNP cord-313694-p2sgaypq 33 4 are be VBP cord-313694-p2sgaypq 33 5 usually usually RB cord-313694-p2sgaypq 33 6 trimmed trim VBN cord-313694-p2sgaypq 33 7 by by IN cord-313694-p2sgaypq 33 8 a a DT cord-313694-p2sgaypq 33 9 tandem tandem JJ cord-313694-p2sgaypq 33 10 pair pair NN cord-313694-p2sgaypq 33 11 of of IN cord-313694-p2sgaypq 33 12 a a DT cord-313694-p2sgaypq 33 13 - - HYPH cord-313694-p2sgaypq 33 14 glucosidases glucosidase NNS cord-313694-p2sgaypq 33 15 to to TO cord-313694-p2sgaypq 33 16 yield yield VB cord-313694-p2sgaypq 33 17 a a DT cord-313694-p2sgaypq 33 18 high high JJ cord-313694-p2sgaypq 33 19 mannose mannose NN cord-313694-p2sgaypq 33 20 N n NN cord-313694-p2sgaypq 33 21 - - HYPH cord-313694-p2sgaypq 33 22 linked link VBN cord-313694-p2sgaypq 33 23 structure structure NN cord-313694-p2sgaypq 33 24 . . . cord-313694-p2sgaypq 34 1 The the DT cord-313694-p2sgaypq 34 2 highmannose highmannose JJ cord-313694-p2sgaypq 34 3 structure structure NN cord-313694-p2sgaypq 34 4 is be VBZ cord-313694-p2sgaypq 34 5 variably variably RB cord-313694-p2sgaypq 34 6 modified modify VBN cord-313694-p2sgaypq 34 7 , , , cord-313694-p2sgaypq 34 8 beginning begin VBG cord-313694-p2sgaypq 34 9 with with IN cord-313694-p2sgaypq 34 10 removal removal NN cord-313694-p2sgaypq 34 11 of of IN cord-313694-p2sgaypq 34 12 mannoses mannose NNS cord-313694-p2sgaypq 34 13 in in IN cord-313694-p2sgaypq 34 14 a a DT cord-313694-p2sgaypq 34 15 typical typical JJ cord-313694-p2sgaypq 34 16 sequence sequence NN cord-313694-p2sgaypq 34 17 by by IN cord-313694-p2sgaypq 34 18 a a DT cord-313694-p2sgaypq 34 19 tandem tandem JJ cord-313694-p2sgaypq 34 20 pair pair NN cord-313694-p2sgaypq 34 21 of of IN cord-313694-p2sgaypq 34 22 o~-mannosidases o~-mannosidase NNS cord-313694-p2sgaypq 34 23 . . . cord-313694-p2sgaypq 35 1 One one CD cord-313694-p2sgaypq 35 2 pathway pathway NN cord-313694-p2sgaypq 35 3 retains retain VBZ cord-313694-p2sgaypq 35 4 most most JJS cord-313694-p2sgaypq 35 5 mannoses mannose NNS cord-313694-p2sgaypq 35 6 but but CC cord-313694-p2sgaypq 35 7 permits permit VBZ cord-313694-p2sgaypq 35 8 additional additional JJ cord-313694-p2sgaypq 35 9 substitutions substitution NNS cord-313694-p2sgaypq 35 10 of of IN cord-313694-p2sgaypq 35 11 e.g. e.g. RB cord-313694-p2sgaypq 35 12 , , , cord-313694-p2sgaypq 35 13 sulfate sulfate NN cord-313694-p2sgaypq 35 14 and/or and/or CC cord-313694-p2sgaypq 35 15 phosphate phosphate NN cord-313694-p2sgaypq 35 16 . . . cord-313694-p2sgaypq 36 1 A a DT cord-313694-p2sgaypq 36 2 second second JJ cord-313694-p2sgaypq 36 3 pathway pathway NN cord-313694-p2sgaypq 36 4 trims trim VBZ cord-313694-p2sgaypq 36 5 down down RP cord-313694-p2sgaypq 36 6 to to IN cord-313694-p2sgaypq 36 7 MansGlcNAc mansglcnac NN cord-313694-p2sgaypq 36 8 2 2 CD cord-313694-p2sgaypq 36 9 and and CC cord-313694-p2sgaypq 36 10 makes make VBZ cord-313694-p2sgaypq 36 11 limited limited JJ cord-313694-p2sgaypq 36 12 additions addition NNS cord-313694-p2sgaypq 36 13 such such JJ cord-313694-p2sgaypq 36 14 as as IN cord-313694-p2sgaypq 36 15 GlcNAc GlcNAc NNP cord-313694-p2sgaypq 36 16 , , , cord-313694-p2sgaypq 36 17 and and CC cord-313694-p2sgaypq 36 18 sometimes sometimes RB cord-313694-p2sgaypq 36 19 Gal Gal NNP cord-313694-p2sgaypq 36 20 and and CC cord-313694-p2sgaypq 36 21 core core NN cord-313694-p2sgaypq 36 22 - - HYPH cord-313694-p2sgaypq 36 23 linked link VBN cord-313694-p2sgaypq 36 24 Fuc fuc NN cord-313694-p2sgaypq 36 25 . . . cord-313694-p2sgaypq 37 1 These these DT cord-313694-p2sgaypq 37 2 are be VBP cord-313694-p2sgaypq 37 3 referred refer VBN cord-313694-p2sgaypq 37 4 to to IN cord-313694-p2sgaypq 37 5 as as IN cord-313694-p2sgaypq 37 6 hybrid hybrid JJ cord-313694-p2sgaypq 37 7 structures structure NNS cord-313694-p2sgaypq 37 8 . . . cord-313694-p2sgaypq 38 1 The the DT cord-313694-p2sgaypq 38 2 third third JJ cord-313694-p2sgaypq 38 3 pathway pathway NN cord-313694-p2sgaypq 38 4 continues continue VBZ cord-313694-p2sgaypq 38 5 the the DT cord-313694-p2sgaypq 38 6 second second JJ cord-313694-p2sgaypq 38 7 pathway pathway NN cord-313694-p2sgaypq 38 8 to to TO cord-313694-p2sgaypq 38 9 build build VB cord-313694-p2sgaypq 38 10 complex complex JJ cord-313694-p2sgaypq 38 11 structures structure NNS cord-313694-p2sgaypq 38 12 usually usually RB cord-313694-p2sgaypq 38 13 terminated terminate VBN cord-313694-p2sgaypq 38 14 by by IN cord-313694-p2sgaypq 38 15 sialic sialic JJ cord-313694-p2sgaypq 38 16 acid acid NN cord-313694-p2sgaypq 38 17 . . . cord-313694-p2sgaypq 39 1 There there EX cord-313694-p2sgaypq 39 2 can can MD cord-313694-p2sgaypq 39 3 be be VB cord-313694-p2sgaypq 39 4 two two CD cord-313694-p2sgaypq 39 5 , , , cord-313694-p2sgaypq 39 6 three three CD cord-313694-p2sgaypq 39 7 or or CC cord-313694-p2sgaypq 39 8 four four CD cord-313694-p2sgaypq 39 9 chains chain NNS cord-313694-p2sgaypq 39 10 emanating emanate VBG cord-313694-p2sgaypq 39 11 from from IN cord-313694-p2sgaypq 39 12 the the DT cord-313694-p2sgaypq 39 13 branching branch VBG cord-313694-p2sgaypq 39 14 mannose mannose NN cord-313694-p2sgaypq 39 15 ( ( -LRB- cord-313694-p2sgaypq 39 16 and and CC cord-313694-p2sgaypq 39 17 secondary secondary JJ cord-313694-p2sgaypq 39 18 branching branch VBG cord-313694-p2sgaypq 39 19 Mans Mans NNP cord-313694-p2sgaypq 39 20 ) ) -RRB- cord-313694-p2sgaypq 39 21 and and CC cord-313694-p2sgaypq 39 22 these these DT cord-313694-p2sgaypq 39 23 structures structure NNS cord-313694-p2sgaypq 39 24 are be VBP cord-313694-p2sgaypq 39 25 accordingly accordingly RB cord-313694-p2sgaypq 39 26 referred refer VBN cord-313694-p2sgaypq 39 27 to to IN cord-313694-p2sgaypq 39 28 as as IN cord-313694-p2sgaypq 39 29 biantennary biantennary NNP cord-313694-p2sgaypq 39 30 , , , cord-313694-p2sgaypq 39 31 triantennary triantennary NNP cord-313694-p2sgaypq 39 32 or or CC cord-313694-p2sgaypq 39 33 tetraantennary tetraantennary JJ cord-313694-p2sgaypq 39 34 complex complex JJ cord-313694-p2sgaypq 39 35 Nlinked Nlinked NNP cord-313694-p2sgaypq 39 36 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 39 37 . . . cord-313694-p2sgaypq 40 1 The the DT cord-313694-p2sgaypq 40 2 sialic sialic JJ cord-313694-p2sgaypq 40 3 acids acid NNS cord-313694-p2sgaypq 40 4 , , , cord-313694-p2sgaypq 40 5 which which WDT cord-313694-p2sgaypq 40 6 appear appear VBP cord-313694-p2sgaypq 40 7 not not RB cord-313694-p2sgaypq 40 8 to to TO cord-313694-p2sgaypq 40 9 precede precede VB cord-313694-p2sgaypq 40 10 echinoderms echinoderm NNS cord-313694-p2sgaypq 40 11 in in IN cord-313694-p2sgaypq 40 12 their -PRON- PRP$ cord-313694-p2sgaypq 40 13 evolutionary evolutionary JJ cord-313694-p2sgaypq 40 14 appearance appearance NN cord-313694-p2sgaypq 40 15 , , , cord-313694-p2sgaypq 40 16 comprise comprise VBP cord-313694-p2sgaypq 40 17 a a DT cord-313694-p2sgaypq 40 18 diverse diverse JJ cord-313694-p2sgaypq 40 19 family family NN cord-313694-p2sgaypq 40 20 of of IN cord-313694-p2sgaypq 40 21 sugars sugar NNS cord-313694-p2sgaypq 40 22 ( ( -LRB- cord-313694-p2sgaypq 40 23 100 100 CD cord-313694-p2sgaypq 40 24 ) ) -RRB- cord-313694-p2sgaypq 40 25 . . . cord-313694-p2sgaypq 41 1 Numerous numerous JJ cord-313694-p2sgaypq 41 2 additional additional JJ cord-313694-p2sgaypq 41 3 substituents substituent NNS cord-313694-p2sgaypq 41 4 including include VBG cord-313694-p2sgaypq 41 5 sulfate sulfate NN cord-313694-p2sgaypq 41 6 , , , cord-313694-p2sgaypq 41 7 phosphate phosphate NN cord-313694-p2sgaypq 41 8 , , , cord-313694-p2sgaypq 41 9 methyl methyl NN cord-313694-p2sgaypq 41 10 groups group NNS cord-313694-p2sgaypq 41 11 and and CC cord-313694-p2sgaypq 41 12 others other NNS cord-313694-p2sgaypq 41 13 have have VBP cord-313694-p2sgaypq 41 14 been be VBN cord-313694-p2sgaypq 41 15 documented document VBN cord-313694-p2sgaypq 41 16 ( ( -LRB- cord-313694-p2sgaypq 41 17 8 8 CD cord-313694-p2sgaypq 41 18 , , , cord-313694-p2sgaypq 41 19 9 9 CD cord-313694-p2sgaypq 41 20 , , , cord-313694-p2sgaypq 41 21 161 161 CD cord-313694-p2sgaypq 41 22 ) ) -RRB- cord-313694-p2sgaypq 41 23 . . . cord-313694-p2sgaypq 42 1 Each each DT cord-313694-p2sgaypq 42 2 step step NN cord-313694-p2sgaypq 42 3 in in IN cord-313694-p2sgaypq 42 4 the the DT cord-313694-p2sgaypq 42 5 glycosylation glycosylation NN cord-313694-p2sgaypq 42 6 pathway pathway NN cord-313694-p2sgaypq 42 7 is be VBZ cord-313694-p2sgaypq 42 8 catalyzed catalyze VBN cord-313694-p2sgaypq 42 9 enzymatically enzymatically RB cord-313694-p2sgaypq 42 10 ; ; : cord-313694-p2sgaypq 42 11 there there EX cord-313694-p2sgaypq 42 12 is be VBZ cord-313694-p2sgaypq 42 13 usually usually RB cord-313694-p2sgaypq 42 14 a a DT cord-313694-p2sgaypq 42 15 unique unique JJ cord-313694-p2sgaypq 42 16 enzyme enzyme NN cord-313694-p2sgaypq 42 17 for for IN cord-313694-p2sgaypq 42 18 each each DT cord-313694-p2sgaypq 42 19 linkage linkage NN cord-313694-p2sgaypq 42 20 position position NN cord-313694-p2sgaypq 42 21 formed form VBN cord-313694-p2sgaypq 42 22 as as IN cord-313694-p2sgaypq 42 23 monosaccharides monosaccharide NNS cord-313694-p2sgaypq 42 24 are be VBP cord-313694-p2sgaypq 42 25 accreted accrete VBN cord-313694-p2sgaypq 42 26 or or CC cord-313694-p2sgaypq 42 27 deleted delete VBN cord-313694-p2sgaypq 42 28 ( ( -LRB- cord-313694-p2sgaypq 42 29 47 47 CD cord-313694-p2sgaypq 42 30 ) ) -RRB- cord-313694-p2sgaypq 42 31 . . . cord-313694-p2sgaypq 43 1 N n CD cord-313694-p2sgaypq 43 2 - - HYPH cord-313694-p2sgaypq 43 3 linked link VBN cord-313694-p2sgaypq 43 4 glycosylation glycosylation NN cord-313694-p2sgaypq 43 5 is be VBZ cord-313694-p2sgaypq 43 6 not not RB cord-313694-p2sgaypq 43 7 template template NN cord-313694-p2sgaypq 43 8 driven drive VBN cord-313694-p2sgaypq 43 9 . . . cord-313694-p2sgaypq 44 1 Only only RB cord-313694-p2sgaypq 44 2 the the DT cord-313694-p2sgaypq 44 3 first first JJ cord-313694-p2sgaypq 44 4 step step NN cord-313694-p2sgaypq 44 5 might may MD cord-313694-p2sgaypq 44 6 be be VB cord-313694-p2sgaypq 44 7 considered consider VBN cord-313694-p2sgaypq 44 8 so so RB cord-313694-p2sgaypq 44 9 , , , cord-313694-p2sgaypq 44 10 inasmuch inasmuch IN cord-313694-p2sgaypq 44 11 there there EX cord-313694-p2sgaypq 44 12 is be VBZ cord-313694-p2sgaypq 44 13 a a DT cord-313694-p2sgaypq 44 14 necessary necessary JJ cord-313694-p2sgaypq 44 15 but but CC cord-313694-p2sgaypq 44 16 not not RB cord-313694-p2sgaypq 44 17 sufficient sufficient JJ cord-313694-p2sgaypq 44 18 requirement requirement NN cord-313694-p2sgaypq 44 19 of of IN cord-313694-p2sgaypq 44 20 an an DT cord-313694-p2sgaypq 44 21 xasn xasn NN cord-313694-p2sgaypq 44 22 - - HYPH cord-313694-p2sgaypq 44 23 x x NN cord-313694-p2sgaypq 44 24 - - HYPH cord-313694-p2sgaypq 44 25 ser ser NNP cord-313694-p2sgaypq 44 26 / / SYM cord-313694-p2sgaypq 44 27 thr thr NNP cord-313694-p2sgaypq 44 28 - - HYPH cord-313694-p2sgaypq 44 29 x x NN cord-313694-p2sgaypq 44 30 sequence sequence NN cord-313694-p2sgaypq 44 31 for for IN cord-313694-p2sgaypq 44 32 the the DT cord-313694-p2sgaypq 44 33 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 44 34 acceptor acceptor NN cord-313694-p2sgaypq 44 35 . . . cord-313694-p2sgaypq 45 1 Protein protein NN cord-313694-p2sgaypq 45 2 structure structure NN cord-313694-p2sgaypq 45 3 or or CC cord-313694-p2sgaypq 45 4 corfformation corfformation NN cord-313694-p2sgaypq 45 5 has have VBZ cord-313694-p2sgaypq 45 6 also also RB cord-313694-p2sgaypq 45 7 been be VBN cord-313694-p2sgaypq 45 8 shown show VBN cord-313694-p2sgaypq 45 9 to to TO cord-313694-p2sgaypq 45 10 influence influence VB cord-313694-p2sgaypq 45 11 whether whether IN cord-313694-p2sgaypq 45 12 a a DT cord-313694-p2sgaypq 45 13 site site NN cord-313694-p2sgaypq 45 14 becomes become VBZ cord-313694-p2sgaypq 45 15 glycosylated glycosylate VBN cord-313694-p2sgaypq 45 16 as as RB cord-313694-p2sgaypq 45 17 well well RB cord-313694-p2sgaypq 45 18 as as IN cord-313694-p2sgaypq 45 19 whether whether IN cord-313694-p2sgaypq 45 20 it -PRON- PRP cord-313694-p2sgaypq 45 21 becomes become VBZ cord-313694-p2sgaypq 45 22 high high JJ cord-313694-p2sgaypq 45 23 mannose mannose NN cord-313694-p2sgaypq 45 24 , , , cord-313694-p2sgaypq 45 25 hybrid hybrid NN cord-313694-p2sgaypq 45 26 , , , cord-313694-p2sgaypq 45 27 or or CC cord-313694-p2sgaypq 45 28 complex complex JJ cord-313694-p2sgaypq 45 29 ( ( -LRB- cord-313694-p2sgaypq 45 30 4 4 CD cord-313694-p2sgaypq 45 31 , , , cord-313694-p2sgaypq 45 32 7 7 CD cord-313694-p2sgaypq 45 33 ) ) -RRB- cord-313694-p2sgaypq 45 34 or or CC cord-313694-p2sgaypq 45 35 whether whether IN cord-313694-p2sgaypq 45 36 it -PRON- PRP cord-313694-p2sgaypq 45 37 receives receive VBZ cord-313694-p2sgaypq 45 38 a a DT cord-313694-p2sgaypq 45 39 phosphodiester phosphodiester NN cord-313694-p2sgaypq 45 40 - - HYPH cord-313694-p2sgaypq 45 41 linked link VBN cord-313694-p2sgaypq 45 42 GlcNAc GlcNAc NNP cord-313694-p2sgaypq 45 43 - - HYPH cord-313694-p2sgaypq 45 44 PO4 PO4 NNP cord-313694-p2sgaypq 45 45 ( ( -LRB- cord-313694-p2sgaypq 45 46 7 7 CD cord-313694-p2sgaypq 45 47 ) ) -RRB- cord-313694-p2sgaypq 45 48 or or CC cord-313694-p2sgaypq 46 1 GalNAc GalNAc NNP cord-313694-p2sgaypq 46 2 - - HYPH cord-313694-p2sgaypq 46 3 SO so RB cord-313694-p2sgaypq 46 4 4 4 CD cord-313694-p2sgaypq 46 5 ( ( -LRB- cord-313694-p2sgaypq 46 6 175 175 CD cord-313694-p2sgaypq 46 7 ) ) -RRB- cord-313694-p2sgaypq 46 8 . . . cord-313694-p2sgaypq 47 1 A a DT cord-313694-p2sgaypq 47 2 relationship relationship NN cord-313694-p2sgaypq 47 3 between between IN cord-313694-p2sgaypq 47 4 position position NN cord-313694-p2sgaypq 47 5 in in IN cord-313694-p2sgaypq 47 6 the the DT cord-313694-p2sgaypq 47 7 polypeptide polypeptide NN cord-313694-p2sgaypq 47 8 chain chain NN cord-313694-p2sgaypq 47 9 ( ( -LRB- cord-313694-p2sgaypq 47 10 distance distance NN cord-313694-p2sgaypq 47 11 from from IN cord-313694-p2sgaypq 47 12 N n NN cord-313694-p2sgaypq 47 13 - - HYPH cord-313694-p2sgaypq 47 14 to to IN cord-313694-p2sgaypq 47 15 C c NN cord-313694-p2sgaypq 47 16 - - HYPH cord-313694-p2sgaypq 47 17 terminus terminus NN cord-313694-p2sgaypq 47 18 ) ) -RRB- cord-313694-p2sgaypq 47 19 and and CC cord-313694-p2sgaypq 47 20 whether whether IN cord-313694-p2sgaypq 47 21 an an DT cord-313694-p2sgaypq 47 22 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 47 23 becomes become VBZ cord-313694-p2sgaypq 47 24 high high JJ cord-313694-p2sgaypq 47 25 mannose mannose NN cord-313694-p2sgaypq 47 26 or or CC cord-313694-p2sgaypq 47 27 complex complex NN cord-313694-p2sgaypq 47 28 has have VBZ cord-313694-p2sgaypq 47 29 been be VBN cord-313694-p2sgaypq 47 30 observed observe VBN cord-313694-p2sgaypq 47 31 ( ( -LRB- cord-313694-p2sgaypq 47 32 6 6 CD cord-313694-p2sgaypq 47 33 ) ) -RRB- cord-313694-p2sgaypq 47 34 . . . cord-313694-p2sgaypq 48 1 Finally finally RB cord-313694-p2sgaypq 48 2 these these DT cord-313694-p2sgaypq 48 3 relations relation NNS cord-313694-p2sgaypq 48 4 are be VBP cord-313694-p2sgaypq 48 5 not not RB cord-313694-p2sgaypq 48 6 absolutely absolutely RB cord-313694-p2sgaypq 48 7 determinate determinate JJ cord-313694-p2sgaypq 48 8 , , , cord-313694-p2sgaypq 48 9 for for IN cord-313694-p2sgaypq 48 10 spontaneous spontaneous JJ cord-313694-p2sgaypq 48 11 heterogeneity heterogeneity NN cord-313694-p2sgaypq 48 12 of of IN cord-313694-p2sgaypq 48 13 carbohydrate carbohydrate NN cord-313694-p2sgaypq 48 14 structures structure NNS cord-313694-p2sgaypq 48 15 at at IN cord-313694-p2sgaypq 48 16 particular particular JJ cord-313694-p2sgaypq 48 17 positions position NNS cord-313694-p2sgaypq 48 18 has have VBZ cord-313694-p2sgaypq 48 19 been be VBN cord-313694-p2sgaypq 48 20 documented document VBN cord-313694-p2sgaypq 48 21 ( ( -LRB- cord-313694-p2sgaypq 48 22 12 12 CD cord-313694-p2sgaypq 48 23 , , , cord-313694-p2sgaypq 48 24 5 5 CD cord-313694-p2sgaypq 48 25 , , , cord-313694-p2sgaypq 48 26 37 37 CD cord-313694-p2sgaypq 48 27 ) ) -RRB- cord-313694-p2sgaypq 48 28 . . . cord-313694-p2sgaypq 49 1 Changes change NNS cord-313694-p2sgaypq 49 2 in in IN cord-313694-p2sgaypq 49 3 structure structure NN cord-313694-p2sgaypq 49 4 also also RB cord-313694-p2sgaypq 49 5 result result VBP cord-313694-p2sgaypq 49 6 from from IN cord-313694-p2sgaypq 49 7 extracellular extracellular JJ cord-313694-p2sgaypq 49 8 influences influence NNS cord-313694-p2sgaypq 49 9 ( ( -LRB- cord-313694-p2sgaypq 49 10 see see VB cord-313694-p2sgaypq 49 11 below below RB cord-313694-p2sgaypq 49 12 ) ) -RRB- cord-313694-p2sgaypq 49 13 . . . cord-313694-p2sgaypq 50 1 The the DT cord-313694-p2sgaypq 50 2 other other JJ cord-313694-p2sgaypq 50 3 major major JJ cord-313694-p2sgaypq 50 4 structural structural JJ cord-313694-p2sgaypq 50 5 class class NN cord-313694-p2sgaypq 50 6 of of IN cord-313694-p2sgaypq 50 7 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 50 8 is be VBZ cord-313694-p2sgaypq 50 9 O o NN cord-313694-p2sgaypq 50 10 - - HYPH cord-313694-p2sgaypq 50 11 linked link VBN cord-313694-p2sgaypq 50 12 on on IN cord-313694-p2sgaypq 50 13 ser ser NNP cord-313694-p2sgaypq 50 14 on on IN cord-313694-p2sgaypq 50 15 thr thr NNP cord-313694-p2sgaypq 50 16 ( ( -LRB- cord-313694-p2sgaypq 50 17 25 25 CD cord-313694-p2sgaypq 50 18 , , , cord-313694-p2sgaypq 50 19 26 26 CD cord-313694-p2sgaypq 50 20 ) ) -RRB- cord-313694-p2sgaypq 50 21 . . . cord-313694-p2sgaypq 51 1 A a DT cord-313694-p2sgaypq 51 2 largely largely RB cord-313694-p2sgaypq 51 3 distinct distinct JJ cord-313694-p2sgaypq 51 4 set set NN cord-313694-p2sgaypq 51 5 of of IN cord-313694-p2sgaypq 51 6 enzymes enzyme NNS cord-313694-p2sgaypq 51 7 catalyzes catalyze VBZ cord-313694-p2sgaypq 51 8 the the DT cord-313694-p2sgaypq 51 9 synthesis synthesis NN cord-313694-p2sgaypq 51 10 of of IN cord-313694-p2sgaypq 51 11 these these DT cord-313694-p2sgaypq 51 12 structures structure NNS cord-313694-p2sgaypq 51 13 . . . cord-313694-p2sgaypq 52 1 These these DT cord-313694-p2sgaypq 52 2 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 52 3 are be VBP cord-313694-p2sgaypq 52 4 built build VBN cord-313694-p2sgaypq 52 5 by by IN cord-313694-p2sgaypq 52 6 monomer monomer NN cord-313694-p2sgaypq 52 7 addition addition NN cord-313694-p2sgaypq 52 8 from from IN cord-313694-p2sgaypq 52 9 sugar sugar NN cord-313694-p2sgaypq 52 10 - - HYPH cord-313694-p2sgaypq 52 11 nucleotide nucleotide JJ cord-313694-p2sgaypq 52 12 donors donor NNS cord-313694-p2sgaypq 52 13 directly directly RB cord-313694-p2sgaypq 52 14 on on IN cord-313694-p2sgaypq 52 15 the the DT cord-313694-p2sgaypq 52 16 polypeptide polypeptide NN cord-313694-p2sgaypq 52 17 rather rather RB cord-313694-p2sgaypq 52 18 than than IN cord-313694-p2sgaypq 52 19 on on IN cord-313694-p2sgaypq 52 20 a a DT cord-313694-p2sgaypq 52 21 lipid lipid NN cord-313694-p2sgaypq 52 22 precursor precursor NN cord-313694-p2sgaypq 52 23 . . . cord-313694-p2sgaypq 53 1 Trimming trimming NN cord-313694-p2sgaypq 53 2 does do VBZ cord-313694-p2sgaypq 53 3 not not RB cord-313694-p2sgaypq 53 4 appear appear VB cord-313694-p2sgaypq 53 5 to to TO cord-313694-p2sgaypq 53 6 play play VB cord-313694-p2sgaypq 53 7 a a DT cord-313694-p2sgaypq 53 8 major major JJ cord-313694-p2sgaypq 53 9 role role NN cord-313694-p2sgaypq 53 10 . . . cord-313694-p2sgaypq 54 1 Gal Gal NNP cord-313694-p2sgaypq 54 2 and and CC cord-313694-p2sgaypq 54 3 GalNAc galnac NN cord-313694-p2sgaypq 54 4 are be VBP cord-313694-p2sgaypq 54 5 typical typical JJ cord-313694-p2sgaypq 54 6 proximal proximal JJ cord-313694-p2sgaypq 54 7 sugars sugar NNS cord-313694-p2sgaypq 54 8 and and CC cord-313694-p2sgaypq 54 9 Man Man NNP cord-313694-p2sgaypq 54 10 is be VBZ cord-313694-p2sgaypq 54 11 rarely rarely RB cord-313694-p2sgaypq 54 12 found find VBN cord-313694-p2sgaypq 54 13 . . . cord-313694-p2sgaypq 55 1 O o UH cord-313694-p2sgaypq 55 2 - - HYPH cord-313694-p2sgaypq 55 3 linked link VBN cord-313694-p2sgaypq 55 4 structures structure NNS cord-313694-p2sgaypq 55 5 are be VBP cord-313694-p2sgaypq 55 6 found find VBN cord-313694-p2sgaypq 55 7 both both CC cord-313694-p2sgaypq 55 8 in in IN cord-313694-p2sgaypq 55 9 branched branched JJ cord-313694-p2sgaypq 55 10 and and CC cord-313694-p2sgaypq 55 11 straight straight JJ cord-313694-p2sgaypq 55 12 chain chain NN cord-313694-p2sgaypq 55 13 forms form NNS cord-313694-p2sgaypq 55 14 . . . cord-313694-p2sgaypq 56 1 O o UH cord-313694-p2sgaypq 56 2 - - HYPH cord-313694-p2sgaypq 56 3 linked link VBN cord-313694-p2sgaypq 56 4 structures structure NNS cord-313694-p2sgaypq 56 5 often often RB cord-313694-p2sgaypq 56 6 resemble resemble VBP cord-313694-p2sgaypq 56 7 the the DT cord-313694-p2sgaypq 56 8 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 56 9 of of IN cord-313694-p2sgaypq 56 10 glycolipids glycolipid NNS cord-313694-p2sgaypq 56 11 ( ( -LRB- cord-313694-p2sgaypq 56 12 45 45 CD cord-313694-p2sgaypq 56 13 ) ) -RRB- cord-313694-p2sgaypq 56 14 , , , cord-313694-p2sgaypq 56 15 and and CC cord-313694-p2sgaypq 56 16 in in IN cord-313694-p2sgaypq 56 17 fact fact NN cord-313694-p2sgaypq 56 18 these these DT cord-313694-p2sgaypq 56 19 may may MD cord-313694-p2sgaypq 56 20 be be VB cord-313694-p2sgaypq 56 21 built build VBN cord-313694-p2sgaypq 56 22 from from IN cord-313694-p2sgaypq 56 23 shared share VBN cord-313694-p2sgaypq 56 24 enzymes enzyme NNS cord-313694-p2sgaypq 56 25 . . . cord-313694-p2sgaypq 57 1 An an DT cord-313694-p2sgaypq 57 2 experimental experimental JJ cord-313694-p2sgaypq 57 3 consideration consideration NN cord-313694-p2sgaypq 57 4 of of IN cord-313694-p2sgaypq 57 5 the the DT cord-313694-p2sgaypq 57 6 role role NN cord-313694-p2sgaypq 57 7 of of IN cord-313694-p2sgaypq 57 8 these these DT cord-313694-p2sgaypq 57 9 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 57 10 on on IN cord-313694-p2sgaypq 57 11 protein protein NN cord-313694-p2sgaypq 57 12 must must MD cord-313694-p2sgaypq 57 13 inevitably inevitably RB cord-313694-p2sgaypq 57 14 involve involve VB cord-313694-p2sgaypq 57 15 an an DT cord-313694-p2sgaypq 57 16 examination examination NN cord-313694-p2sgaypq 57 17 of of IN cord-313694-p2sgaypq 57 18 homologous homologous JJ cord-313694-p2sgaypq 57 19 glycolipids glycolipid NNS cord-313694-p2sgaypq 57 20 . . . cord-313694-p2sgaypq 58 1 Although although IN cord-313694-p2sgaypq 58 2 the the DT cord-313694-p2sgaypq 58 3 N n NN cord-313694-p2sgaypq 58 4 - - HYPH cord-313694-p2sgaypq 58 5 linked link VBN cord-313694-p2sgaypq 58 6 and and CC cord-313694-p2sgaypq 58 7 O o NN cord-313694-p2sgaypq 58 8 - - HYPH cord-313694-p2sgaypq 58 9 linked link VBN cord-313694-p2sgaypq 58 10 structures structure NNS cord-313694-p2sgaypq 58 11 discussed discuss VBN cord-313694-p2sgaypq 58 12 above above IN cord-313694-p2sgaypq 58 13 account account NN cord-313694-p2sgaypq 58 14 for for IN cord-313694-p2sgaypq 58 15 95 95 CD cord-313694-p2sgaypq 58 16 - - SYM cord-313694-p2sgaypq 58 17 100 100 CD cord-313694-p2sgaypq 58 18 % % NN cord-313694-p2sgaypq 58 19 of of IN cord-313694-p2sgaypq 58 20 incorporation incorporation NN cord-313694-p2sgaypq 58 21 of of IN cord-313694-p2sgaypq 58 22 labelled label VBN cord-313694-p2sgaypq 58 23 sugar sugar NN cord-313694-p2sgaypq 58 24 precursors precursor NNS cord-313694-p2sgaypq 58 25 into into IN cord-313694-p2sgaypq 58 26 cellular cellular JJ cord-313694-p2sgaypq 58 27 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 58 28 , , , cord-313694-p2sgaypq 58 29 numerous numerous JJ cord-313694-p2sgaypq 58 30 additional additional JJ cord-313694-p2sgaypq 58 31 small small JJ cord-313694-p2sgaypq 58 32 classes class NNS cord-313694-p2sgaypq 58 33 of of IN cord-313694-p2sgaypq 58 34 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 58 35 are be VBP cord-313694-p2sgaypq 58 36 also also RB cord-313694-p2sgaypq 58 37 found find VBN cord-313694-p2sgaypq 58 38 . . . cord-313694-p2sgaypq 59 1 For for IN cord-313694-p2sgaypq 59 2 example example NN cord-313694-p2sgaypq 59 3 , , , cord-313694-p2sgaypq 59 4 GalGlc GalGlc NNP cord-313694-p2sgaypq 59 5 is be VBZ cord-313694-p2sgaypq 59 6 found find VBN cord-313694-p2sgaypq 59 7 on on IN cord-313694-p2sgaypq 59 8 hydroxylysine hydroxylysine NNP cord-313694-p2sgaypq 59 9 and and CC cord-313694-p2sgaypq 59 10 hydroxyproline hydroxyproline NNP cord-313694-p2sgaypq 59 11 of of IN cord-313694-p2sgaypq 59 12 collagens collagens NNP cord-313694-p2sgaypq 59 13 . . . cord-313694-p2sgaypq 60 1 GlcNAc glcnac NN cord-313694-p2sgaypq 60 2 - - HYPH cord-313694-p2sgaypq 60 3 POn POn NNP cord-313694-p2sgaypq 60 4 - - HYPH cord-313694-p2sgaypq 60 5 ser ser NNP cord-313694-p2sgaypq 60 6 is be VBZ cord-313694-p2sgaypq 60 7 found find VBN cord-313694-p2sgaypq 60 8 on on IN cord-313694-p2sgaypq 60 9 a a DT cord-313694-p2sgaypq 60 10 lysosomal lysosomal JJ cord-313694-p2sgaypq 60 11 enzyme enzyme NN cord-313694-p2sgaypq 60 12 in in IN cord-313694-p2sgaypq 60 13 D. D. NNP cord-313694-p2sgaypq 60 14 discoideum discoideum NNP cord-313694-p2sgaypq 60 15 ( ( -LRB- cord-313694-p2sgaypq 60 16 18 18 CD cord-313694-p2sgaypq 60 17 ) ) -RRB- cord-313694-p2sgaypq 60 18 and and CC cord-313694-p2sgaypq 60 19 GlcNAc GlcNAc NNP cord-313694-p2sgaypq 60 20 - - HYPH cord-313694-p2sgaypq 60 21 asn asn NNP cord-313694-p2sgaypq 60 22 is be VBZ cord-313694-p2sgaypq 60 23 found find VBN cord-313694-p2sgaypq 60 24 on on IN cord-313694-p2sgaypq 60 25 certain certain JJ cord-313694-p2sgaypq 60 26 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 60 27 of of IN cord-313694-p2sgaypq 60 28 what what WP cord-313694-p2sgaypq 60 29 is be VBZ cord-313694-p2sgaypq 60 30 probably probably RB cord-313694-p2sgaypq 60 31 the the DT cord-313694-p2sgaypq 60 32 nuclear nuclear JJ cord-313694-p2sgaypq 60 33 envelope envelope NN cord-313694-p2sgaypq 60 34 ( ( -LRB- cord-313694-p2sgaypq 60 35 19 19 CD cord-313694-p2sgaypq 60 36 ) ) -RRB- cord-313694-p2sgaypq 60 37 . . . cord-313694-p2sgaypq 61 1 Archeobacterial archeobacterial JJ cord-313694-p2sgaypq 61 2 proteins protein NNS cord-313694-p2sgaypq 61 3 are be VBP cord-313694-p2sgaypq 61 4 also also RB cord-313694-p2sgaypq 61 5 glycosylated glycosylate VBN cord-313694-p2sgaypq 61 6 . . . cord-313694-p2sgaypq 62 1 A a DT cord-313694-p2sgaypq 62 2 major major JJ cord-313694-p2sgaypq 62 3 class class NN cord-313694-p2sgaypq 62 4 of of IN cord-313694-p2sgaypq 62 5 these these DT cord-313694-p2sgaypq 62 6 glycosylations glycosylation NNS cord-313694-p2sgaypq 62 7 shares share VBZ cord-313694-p2sgaypq 62 8 some some DT cord-313694-p2sgaypq 62 9 homology homology NN cord-313694-p2sgaypq 62 10 with with IN cord-313694-p2sgaypq 62 11 N n CD cord-313694-p2sgaypq 62 12 - - HYPH cord-313694-p2sgaypq 62 13 glycosylation glycosylation NN cord-313694-p2sgaypq 62 14 and and CC cord-313694-p2sgaypq 62 15 may may MD cord-313694-p2sgaypq 62 16 be be VB cord-313694-p2sgaypq 62 17 evolutionarily evolutionarily RB cord-313694-p2sgaypq 62 18 related relate VBN cord-313694-p2sgaypq 62 19 ( ( -LRB- cord-313694-p2sgaypq 62 20 10 10 CD cord-313694-p2sgaypq 62 21 , , , cord-313694-p2sgaypq 62 22 38 38 CD cord-313694-p2sgaypq 62 23 , , , cord-313694-p2sgaypq 62 24 11 11 CD cord-313694-p2sgaypq 62 25 ) ) -RRB- cord-313694-p2sgaypq 62 26 . . . cord-313694-p2sgaypq 63 1 A a DT cord-313694-p2sgaypq 63 2 polyisoprenoid polyisoprenoid JJ cord-313694-p2sgaypq 63 3 lipid lipid NN cord-313694-p2sgaypq 63 4 carrier carrier NN cord-313694-p2sgaypq 63 5 is be VBZ cord-313694-p2sgaypq 63 6 utilized utilize VBN cord-313694-p2sgaypq 63 7 prior prior RB cord-313694-p2sgaypq 63 8 to to IN cord-313694-p2sgaypq 63 9 en en NNP cord-313694-p2sgaypq 63 10 bloc bloc NNP cord-313694-p2sgaypq 63 11 transfer transfer NN cord-313694-p2sgaypq 63 12 . . . cord-313694-p2sgaypq 64 1 The the DT cord-313694-p2sgaypq 64 2 ancient ancient JJ cord-313694-p2sgaypq 64 3 character character NN cord-313694-p2sgaypq 64 4 of of IN cord-313694-p2sgaypq 64 5 the the DT cord-313694-p2sgaypq 64 6 mammalian mammalian JJ cord-313694-p2sgaypq 64 7 N N NNP cord-313694-p2sgaypq 64 8 - - HYPH cord-313694-p2sgaypq 64 9 linked link VBN cord-313694-p2sgaypq 64 10 glycan glycan NN cord-313694-p2sgaypq 64 11 suggests suggest VBZ cord-313694-p2sgaypq 64 12 important important JJ cord-313694-p2sgaypq 64 13 functional functional JJ cord-313694-p2sgaypq 64 14 attributes attribute NNS cord-313694-p2sgaypq 64 15 for for IN cord-313694-p2sgaypq 64 16 his -PRON- PRP$ cord-313694-p2sgaypq 64 17 posttranslational posttranslational JJ cord-313694-p2sgaypq 64 18 modification modification NN cord-313694-p2sgaypq 64 19 . . . cord-313694-p2sgaypq 65 1 Several several JJ cord-313694-p2sgaypq 65 2 physical physical JJ cord-313694-p2sgaypq 65 3 methods method NNS cord-313694-p2sgaypq 65 4 have have VBP cord-313694-p2sgaypq 65 5 been be VBN cord-313694-p2sgaypq 65 6 applied apply VBN cord-313694-p2sgaypq 65 7 to to TO cord-313694-p2sgaypq 65 8 ascertain ascertain VB cord-313694-p2sgaypq 65 9 the the DT cord-313694-p2sgaypq 65 10 conformation conformation NN cord-313694-p2sgaypq 65 11 of of IN cord-313694-p2sgaypq 65 12 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 65 13 on on IN cord-313694-p2sgaypq 65 14 proteins protein NNS cord-313694-p2sgaypq 65 15 ( ( -LRB- cord-313694-p2sgaypq 65 16 30 30 CD cord-313694-p2sgaypq 65 17 , , , cord-313694-p2sgaypq 65 18 31 31 CD cord-313694-p2sgaypq 65 19 ) ) -RRB- cord-313694-p2sgaypq 65 20 . . . cord-313694-p2sgaypq 66 1 Studies study NNS cord-313694-p2sgaypq 66 2 in in IN cord-313694-p2sgaypq 66 3 model model NN cord-313694-p2sgaypq 66 4 systems system NNS cord-313694-p2sgaypq 66 5 have have VBP cord-313694-p2sgaypq 66 6 implied imply VBN cord-313694-p2sgaypq 66 7 that that IN cord-313694-p2sgaypq 66 8 there there EX cord-313694-p2sgaypq 66 9 is be VBZ cord-313694-p2sgaypq 66 10 a a DT cord-313694-p2sgaypq 66 11 preferred preferred JJ cord-313694-p2sgaypq 66 12 conformation conformation NN cord-313694-p2sgaypq 66 13 at at IN cord-313694-p2sgaypq 66 14 least least JJS cord-313694-p2sgaypq 66 15 for for IN cord-313694-p2sgaypq 66 16 the the DT cord-313694-p2sgaypq 66 17 core core NN cord-313694-p2sgaypq 66 18 sugars sugar NNS cord-313694-p2sgaypq 66 19 of of IN cord-313694-p2sgaypq 66 20 N n CD cord-313694-p2sgaypq 66 21 - - HYPH cord-313694-p2sgaypq 66 22 linked link VBN cord-313694-p2sgaypq 66 23 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 66 24 chains chain NNS cord-313694-p2sgaypq 66 25 . . . cord-313694-p2sgaypq 67 1 This this DT cord-313694-p2sgaypq 67 2 conformation conformation NN cord-313694-p2sgaypq 67 3 is be VBZ cord-313694-p2sgaypq 67 4 stabilized stabilize VBN cord-313694-p2sgaypq 67 5 by by IN cord-313694-p2sgaypq 67 6 hydrogen hydrogen NN cord-313694-p2sgaypq 67 7 bonding bonding NN cord-313694-p2sgaypq 67 8 with with IN cord-313694-p2sgaypq 67 9 the the DT cord-313694-p2sgaypq 67 10 polypeptide polypeptide NN cord-313694-p2sgaypq 67 11 chain chain NN cord-313694-p2sgaypq 67 12 , , , cord-313694-p2sgaypq 67 13 which which WDT cord-313694-p2sgaypq 67 14 orients orient VBZ cord-313694-p2sgaypq 67 15 the the DT cord-313694-p2sgaypq 67 16 structure structure NN cord-313694-p2sgaypq 67 17 , , , cord-313694-p2sgaypq 67 18 and and CC cord-313694-p2sgaypq 67 19 limited limited JJ cord-313694-p2sgaypq 67 20 intrachain intrachain NNP cord-313694-p2sgaypq 67 21 hydrogenbonding hydrogenbonding NNP cord-313694-p2sgaypq 67 22 . . . cord-313694-p2sgaypq 68 1 The the DT cord-313694-p2sgaypq 68 2 existence existence NN cord-313694-p2sgaypq 68 3 of of IN cord-313694-p2sgaypq 68 4 preferred preferred JJ cord-313694-p2sgaypq 68 5 conformations conformation NNS cord-313694-p2sgaypq 68 6 implies imply VBZ cord-313694-p2sgaypq 68 7 that that IN cord-313694-p2sgaypq 68 8 shape shape NN cord-313694-p2sgaypq 68 9 may may MD cord-313694-p2sgaypq 68 10 be be VB cord-313694-p2sgaypq 68 11 important important JJ cord-313694-p2sgaypq 68 12 for for IN cord-313694-p2sgaypq 68 13 specific specific JJ cord-313694-p2sgaypq 68 14 interactions interaction NNS cord-313694-p2sgaypq 68 15 of of IN cord-313694-p2sgaypq 68 16 protein protein NN cord-313694-p2sgaypq 68 17 - - HYPH cord-313694-p2sgaypq 68 18 linked link VBN cord-313694-p2sgaypq 68 19 carbohydrate carbohydrate NN cord-313694-p2sgaypq 68 20 with with IN cord-313694-p2sgaypq 68 21 receptors receptor NNS cord-313694-p2sgaypq 68 22 . . . cord-313694-p2sgaypq 69 1 N n CD cord-313694-p2sgaypq 69 2 - - HYPH cord-313694-p2sgaypq 69 3 linked link VBN cord-313694-p2sgaypq 69 4 glycosylation glycosylation NN cord-313694-p2sgaypq 69 5 appears appear VBZ cord-313694-p2sgaypq 69 6 to to TO cord-313694-p2sgaypq 69 7 occur occur VB cord-313694-p2sgaypq 69 8 only only RB cord-313694-p2sgaypq 69 9 in in IN cord-313694-p2sgaypq 69 10 the the DT cord-313694-p2sgaypq 69 11 rough rough JJ cord-313694-p2sgaypq 69 12 endoplasmic endoplasmic NN cord-313694-p2sgaypq 69 13 reticulum reticulum NN cord-313694-p2sgaypq 69 14 ( ( -LRB- cord-313694-p2sgaypq 69 15 RER RER NNP cord-313694-p2sgaypq 69 16 ) ) -RRB- cord-313694-p2sgaypq 69 17 and and CC cord-313694-p2sgaypq 69 18 hence hence RB cord-313694-p2sgaypq 69 19 only only RB cord-313694-p2sgaypq 69 20 to to IN cord-313694-p2sgaypq 69 21 proteins protein NNS cord-313694-p2sgaypq 69 22 which which WDT cord-313694-p2sgaypq 69 23 possess possess VBP cord-313694-p2sgaypq 69 24 a a DT cord-313694-p2sgaypq 69 25 signal signal JJ cord-313694-p2sgaypq 69 26 sequence sequence NN cord-313694-p2sgaypq 69 27 ( ( -LRB- cord-313694-p2sgaypq 69 28 150 150 CD cord-313694-p2sgaypq 69 29 ) ) -RRB- cord-313694-p2sgaypq 69 30 . . . cord-313694-p2sgaypq 70 1 The the DT cord-313694-p2sgaypq 70 2 process process NN cord-313694-p2sgaypq 70 3 is be VBZ cord-313694-p2sgaypq 70 4 co co JJ cord-313694-p2sgaypq 70 5 - - JJ cord-313694-p2sgaypq 70 6 or or CC cord-313694-p2sgaypq 70 7 post post JJ cord-313694-p2sgaypq 70 8 - - JJ cord-313694-p2sgaypq 70 9 translational translational JJ cord-313694-p2sgaypq 70 10 ( ( -LRB- cord-313694-p2sgaypq 70 11 14 14 CD cord-313694-p2sgaypq 70 12 ) ) -RRB- cord-313694-p2sgaypq 70 13 . . . cord-313694-p2sgaypq 71 1 Mannose mannose NN cord-313694-p2sgaypq 71 2 trimming trimming NN cord-313694-p2sgaypq 71 3 begins begin VBZ cord-313694-p2sgaypq 71 4 in in IN cord-313694-p2sgaypq 71 5 the the DT cord-313694-p2sgaypq 71 6 RER rer NN cord-313694-p2sgaypq 71 7 but but CC cord-313694-p2sgaypq 71 8 can can MD cord-313694-p2sgaypq 71 9 be be VB cord-313694-p2sgaypq 71 10 concluded conclude VBN cord-313694-p2sgaypq 71 11 in in IN cord-313694-p2sgaypq 71 12 Golgi Golgi NNP cord-313694-p2sgaypq 71 13 . . . cord-313694-p2sgaypq 72 1 Modification modification NN cord-313694-p2sgaypq 72 2 of of IN cord-313694-p2sgaypq 72 3 high high JJ cord-313694-p2sgaypq 72 4 - - HYPH cord-313694-p2sgaypq 72 5 mannose mannose NN cord-313694-p2sgaypq 72 6 forms form NNS cord-313694-p2sgaypq 72 7 or or CC cord-313694-p2sgaypq 72 8 conversion conversion NN cord-313694-p2sgaypq 72 9 to to TO cord-313694-p2sgaypq 72 10 hybrid hybrid VB cord-313694-p2sgaypq 72 11 or or CC cord-313694-p2sgaypq 72 12 complex complex JJ cord-313694-p2sgaypq 72 13 forms form NNS cord-313694-p2sgaypq 72 14 occurs occur VBZ cord-313694-p2sgaypq 72 15 in in IN cord-313694-p2sgaypq 72 16 the the DT cord-313694-p2sgaypq 72 17 Golgi Golgi NNP cord-313694-p2sgaypq 72 18 . . . cord-313694-p2sgaypq 73 1 Nearly nearly RB cord-313694-p2sgaypq 73 2 all all DT cord-313694-p2sgaypq 73 3 glycosylation glycosylation NN cord-313694-p2sgaypq 73 4 is be VBZ cord-313694-p2sgaypq 73 5 believed believe VBN cord-313694-p2sgaypq 73 6 to to TO cord-313694-p2sgaypq 73 7 be be VB cord-313694-p2sgaypq 73 8 restricted restrict VBN cord-313694-p2sgaypq 73 9 to to IN cord-313694-p2sgaypq 73 10 these these DT cord-313694-p2sgaypq 73 11 two two CD cord-313694-p2sgaypq 73 12 compartments compartment NNS cord-313694-p2sgaypq 73 13 . . . cord-313694-p2sgaypq 74 1 Certain certain JJ cord-313694-p2sgaypq 74 2 steps step NNS cord-313694-p2sgaypq 74 3 in in IN cord-313694-p2sgaypq 74 4 glycosylation glycosylation NN cord-313694-p2sgaypq 74 5 have have VBP cord-313694-p2sgaypq 74 6 , , , cord-313694-p2sgaypq 74 7 however however RB cord-313694-p2sgaypq 74 8 , , , cord-313694-p2sgaypq 74 9 been be VBN cord-313694-p2sgaypq 74 10 postulated postulate VBN cord-313694-p2sgaypq 74 11 to to TO cord-313694-p2sgaypq 74 12 occur occur VB cord-313694-p2sgaypq 74 13 in in IN cord-313694-p2sgaypq 74 14 the the DT cord-313694-p2sgaypq 74 15 SER SER NNP cord-313694-p2sgaypq 74 16 , , , cord-313694-p2sgaypq 74 17 secretory secretory JJ cord-313694-p2sgaypq 74 18 vesicles vesicle NNS cord-313694-p2sgaypq 74 19 , , , cord-313694-p2sgaypq 74 20 nuclear nuclear JJ cord-313694-p2sgaypq 74 21 envelope envelope NN cord-313694-p2sgaypq 74 22 and and CC cord-313694-p2sgaypq 74 23 cell cell NN cord-313694-p2sgaypq 74 24 surface surface NN cord-313694-p2sgaypq 74 25 ( ( -LRB- cord-313694-p2sgaypq 74 26 e.g. e.g. RB cord-313694-p2sgaypq 74 27 , , , cord-313694-p2sgaypq 74 28 43 43 CD cord-313694-p2sgaypq 74 29 , , , cord-313694-p2sgaypq 74 30 139 139 CD cord-313694-p2sgaypq 74 31 , , , cord-313694-p2sgaypq 74 32 173 173 CD cord-313694-p2sgaypq 74 33 ) ) -RRB- cord-313694-p2sgaypq 74 34 . . . cord-313694-p2sgaypq 75 1 Of of RB cord-313694-p2sgaypq 75 2 course course RB cord-313694-p2sgaypq 75 3 , , , cord-313694-p2sgaypq 75 4 deglycosylation deglycosylation NN cord-313694-p2sgaypq 75 5 occurs occur VBZ cord-313694-p2sgaypq 75 6 in in IN cord-313694-p2sgaypq 75 7 lysosomes lysosome NNS cord-313694-p2sgaypq 75 8 as as IN cord-313694-p2sgaypq 75 9 a a DT cord-313694-p2sgaypq 75 10 part part NN cord-313694-p2sgaypq 75 11 of of IN cord-313694-p2sgaypq 75 12 protein protein NN cord-313694-p2sgaypq 75 13 turnover turnover NN cord-313694-p2sgaypq 75 14 ( ( -LRB- cord-313694-p2sgaypq 75 15 102 102 CD cord-313694-p2sgaypq 75 16 ) ) -RRB- cord-313694-p2sgaypq 75 17 . . . cord-313694-p2sgaypq 76 1 O o UH cord-313694-p2sgaypq 76 2 - - HYPH cord-313694-p2sgaypq 76 3 linked link VBN cord-313694-p2sgaypq 76 4 glycosylation glycosylation NN cord-313694-p2sgaypq 76 5 appears appear VBZ cord-313694-p2sgaypq 76 6 to to TO cord-313694-p2sgaypq 76 7 be be VB cord-313694-p2sgaypq 76 8 initiated initiate VBN cord-313694-p2sgaypq 76 9 and and CC cord-313694-p2sgaypq 76 10 concluded conclude VBN cord-313694-p2sgaypq 76 11 in in IN cord-313694-p2sgaypq 76 12 the the DT cord-313694-p2sgaypq 76 13 Golgi Golgi NNP cord-313694-p2sgaypq 76 14 ( ( -LRB- cord-313694-p2sgaypq 76 15 25 25 CD cord-313694-p2sgaypq 76 16 , , , cord-313694-p2sgaypq 76 17 26 26 CD cord-313694-p2sgaypq 76 18 , , , cord-313694-p2sgaypq 76 19 but but CC cord-313694-p2sgaypq 76 20 see see VB cord-313694-p2sgaypq 76 21 27 27 CD cord-313694-p2sgaypq 76 22 ) ) -RRB- cord-313694-p2sgaypq 76 23 . . . cord-313694-p2sgaypq 77 1 As as IN cord-313694-p2sgaypq 77 2 for for IN cord-313694-p2sgaypq 77 3 N n CD cord-313694-p2sgaypq 77 4 - - HYPH cord-313694-p2sgaypq 77 5 linked link VBN cord-313694-p2sgaypq 77 6 glycosylation glycosylation NN cord-313694-p2sgaypq 77 7 , , , cord-313694-p2sgaypq 77 8 there there EX cord-313694-p2sgaypq 77 9 has have VBZ cord-313694-p2sgaypq 77 10 been be VBN cord-313694-p2sgaypq 77 11 some some DT cord-313694-p2sgaypq 77 12 resolution resolution NN cord-313694-p2sgaypq 77 13 of of IN cord-313694-p2sgaypq 77 14 processes process NNS cord-313694-p2sgaypq 77 15 between between IN cord-313694-p2sgaypq 77 16 the the DT cord-313694-p2sgaypq 77 17 cis cis NNP cord-313694-p2sgaypq 77 18 , , , cord-313694-p2sgaypq 77 19 medial medial JJ cord-313694-p2sgaypq 77 20 and and CC cord-313694-p2sgaypq 77 21 trans trans JJ cord-313694-p2sgaypq 77 22 elements element NNS cord-313694-p2sgaypq 77 23 of of IN cord-313694-p2sgaypq 77 24 the the DT cord-313694-p2sgaypq 77 25 Golgi Golgi NNP cord-313694-p2sgaypq 77 26 apparatus apparatus NN cord-313694-p2sgaypq 77 27 . . . cord-313694-p2sgaypq 78 1 Nearly nearly RB cord-313694-p2sgaypq 78 2 all all DT cord-313694-p2sgaypq 78 3 proteins protein NNS cord-313694-p2sgaypq 78 4 which which WDT cord-313694-p2sgaypq 78 5 pass pass VBP cord-313694-p2sgaypq 78 6 through through IN cord-313694-p2sgaypq 78 7 the the DT cord-313694-p2sgaypq 78 8 RER RER NNP cord-313694-p2sgaypq 78 9 and and CC cord-313694-p2sgaypq 78 10 Golgi Golgi NNP cord-313694-p2sgaypq 78 11 become become VBP cord-313694-p2sgaypq 78 12 glycosylated glycosylated JJ cord-313694-p2sgaypq 78 13 in in IN cord-313694-p2sgaypq 78 14 some some DT cord-313694-p2sgaypq 78 15 form form NN cord-313694-p2sgaypq 78 16 . . . cord-313694-p2sgaypq 79 1 One one CD cord-313694-p2sgaypq 79 2 exception exception NN cord-313694-p2sgaypq 79 3 is be VBZ cord-313694-p2sgaypq 79 4 the the DT cord-313694-p2sgaypq 79 5 secretory secretory JJ cord-313694-p2sgaypq 79 6 protein protein NN cord-313694-p2sgaypq 79 7 serum serum NN cord-313694-p2sgaypq 79 8 albumin albumin NN cord-313694-p2sgaypq 79 9 ( ( -LRB- cord-313694-p2sgaypq 79 10 32 32 CD cord-313694-p2sgaypq 79 11 ) ) -RRB- cord-313694-p2sgaypq 79 12 , , , cord-313694-p2sgaypq 79 13 which which WDT cord-313694-p2sgaypq 79 14 is be VBZ cord-313694-p2sgaypq 79 15 synthesized synthesize VBN cord-313694-p2sgaypq 79 16 in in IN cord-313694-p2sgaypq 79 17 hepatocytes hepatocyte NNS cord-313694-p2sgaypq 79 18 . . . cord-313694-p2sgaypq 80 1 There there EX cord-313694-p2sgaypq 80 2 is be VBZ cord-313694-p2sgaypq 80 3 no no DT cord-313694-p2sgaypq 80 4 evidence evidence NN cord-313694-p2sgaypq 80 5 for for IN cord-313694-p2sgaypq 80 6 a a DT cord-313694-p2sgaypq 80 7 glycosylated glycosylated JJ cord-313694-p2sgaypq 80 8 precursor precursor NN cord-313694-p2sgaypq 80 9 . . . cord-313694-p2sgaypq 81 1 It -PRON- PRP cord-313694-p2sgaypq 81 2 should should MD cord-313694-p2sgaypq 81 3 be be VB cord-313694-p2sgaypq 81 4 recognized recognize VBN cord-313694-p2sgaypq 81 5 that that IN cord-313694-p2sgaypq 81 6 at at IN cord-313694-p2sgaypq 81 7 least least JJS cord-313694-p2sgaypq 81 8 some some DT cord-313694-p2sgaypq 81 9 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 81 10 , , , cord-313694-p2sgaypq 81 11 e.g. e.g. RB cord-313694-p2sgaypq 81 12 , , , cord-313694-p2sgaypq 81 13 cell cell NN cord-313694-p2sgaypq 81 14 surface surface NN cord-313694-p2sgaypq 81 15 transferrin transferrin NN cord-313694-p2sgaypq 81 16 receptor receptor NN cord-313694-p2sgaypq 81 17 , , , cord-313694-p2sgaypq 81 18 can can MD cord-313694-p2sgaypq 81 19 probably probably RB cord-313694-p2sgaypq 81 20 be be VB cord-313694-p2sgaypq 81 21 reexposed reexpose VBN cord-313694-p2sgaypq 81 22 to to IN cord-313694-p2sgaypq 81 23 the the DT cord-313694-p2sgaypq 81 24 Golgi Golgi NNP cord-313694-p2sgaypq 81 25 compartment compartment NN cord-313694-p2sgaypq 81 26 subsequent subsequent JJ cord-313694-p2sgaypq 81 27 to to IN cord-313694-p2sgaypq 81 28 primary primary JJ cord-313694-p2sgaypq 81 29 passage passage NN cord-313694-p2sgaypq 81 30 through through IN cord-313694-p2sgaypq 81 31 this this DT cord-313694-p2sgaypq 81 32 organelle organelle NN cord-313694-p2sgaypq 81 33 ( ( -LRB- cord-313694-p2sgaypq 81 34 112 112 CD cord-313694-p2sgaypq 81 35 ) ) -RRB- cord-313694-p2sgaypq 81 36 . . . cord-313694-p2sgaypq 82 1 This this DT cord-313694-p2sgaypq 82 2 provides provide VBZ cord-313694-p2sgaypq 82 3 new new JJ cord-313694-p2sgaypq 82 4 opportunities opportunity NNS cord-313694-p2sgaypq 82 5 for for IN cord-313694-p2sgaypq 82 6 glycosylation glycosylation NN cord-313694-p2sgaypq 82 7 subsequent subsequent JJ cord-313694-p2sgaypq 82 8 to to IN cord-313694-p2sgaypq 82 9 initial initial JJ cord-313694-p2sgaypq 82 10 synthesis synthesis NN cord-313694-p2sgaypq 82 11 . . . cord-313694-p2sgaypq 83 1 Occasional occasional JJ cord-313694-p2sgaypq 83 2 reports report NNS cord-313694-p2sgaypq 83 3 have have VBP cord-313694-p2sgaypq 83 4 appeared appear VBN cord-313694-p2sgaypq 83 5 in in IN cord-313694-p2sgaypq 83 6 the the DT cord-313694-p2sgaypq 83 7 literature literature NN cord-313694-p2sgaypq 83 8 regarding regard VBG cord-313694-p2sgaypq 83 9 the the DT cord-313694-p2sgaypq 83 10 presence presence NN cord-313694-p2sgaypq 83 11 of of IN cord-313694-p2sgaypq 83 12 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 83 13 in in IN cord-313694-p2sgaypq 83 14 cytoplasmic cytoplasmic JJ cord-313694-p2sgaypq 83 15 compartments compartment NNS cord-313694-p2sgaypq 83 16 topologically topologically RB cord-313694-p2sgaypq 83 17 discontinuous discontinuous JJ cord-313694-p2sgaypq 83 18 with with IN cord-313694-p2sgaypq 83 19 the the DT cord-313694-p2sgaypq 83 20 lumen lumen NN cord-313694-p2sgaypq 83 21 of of IN cord-313694-p2sgaypq 83 22 the the DT cord-313694-p2sgaypq 83 23 RER RER NNP cord-313694-p2sgaypq 83 24 and and CC cord-313694-p2sgaypq 83 25 Golgi Golgi NNP cord-313694-p2sgaypq 83 26 . . . cord-313694-p2sgaypq 84 1 Histones Histones NNPS cord-313694-p2sgaypq 84 2 and and CC cord-313694-p2sgaypq 84 3 other other JJ cord-313694-p2sgaypq 84 4 nucleoplasmic nucleoplasmic JJ cord-313694-p2sgaypq 84 5 proteins protein NNS cord-313694-p2sgaypq 84 6 ( ( -LRB- cord-313694-p2sgaypq 84 7 68 68 CD cord-313694-p2sgaypq 84 8 , , , cord-313694-p2sgaypq 84 9 77 77 CD cord-313694-p2sgaypq 84 10 , , , cord-313694-p2sgaypq 84 11 78 78 CD cord-313694-p2sgaypq 84 12 ) ) -RRB- cord-313694-p2sgaypq 84 13 , , , cord-313694-p2sgaypq 84 14 a a DT cord-313694-p2sgaypq 84 15 ribosomal ribosomal JJ cord-313694-p2sgaypq 84 16 protein protein NN cord-313694-p2sgaypq 84 17 ( ( -LRB- cord-313694-p2sgaypq 84 18 79 79 CD cord-313694-p2sgaypq 84 19 ) ) -RRB- cord-313694-p2sgaypq 84 20 and and CC cord-313694-p2sgaypq 84 21 certain certain JJ cord-313694-p2sgaypq 84 22 mitochondrial mitochondrial JJ cord-313694-p2sgaypq 84 23 proteins protein NNS cord-313694-p2sgaypq 84 24 ( ( -LRB- cord-313694-p2sgaypq 84 25 132 132 CD cord-313694-p2sgaypq 84 26 , , , cord-313694-p2sgaypq 84 27 174 174 CD cord-313694-p2sgaypq 84 28 ) ) -RRB- cord-313694-p2sgaypq 84 29 have have VBP cord-313694-p2sgaypq 84 30 been be VBN cord-313694-p2sgaypq 84 31 suggested suggest VBN cord-313694-p2sgaypq 84 32 to to TO cord-313694-p2sgaypq 84 33 be be VB cord-313694-p2sgaypq 84 34 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 84 35 . . . cord-313694-p2sgaypq 85 1 These these DT cord-313694-p2sgaypq 85 2 findings finding NNS cord-313694-p2sgaypq 85 3 contradict contradict VBP cord-313694-p2sgaypq 85 4 the the DT cord-313694-p2sgaypq 85 5 dogma dogma NN cord-313694-p2sgaypq 85 6 that that WDT cord-313694-p2sgaypq 85 7 glycosylation glycosylation NN cord-313694-p2sgaypq 85 8 is be VBZ cord-313694-p2sgaypq 85 9 strictly strictly RB cord-313694-p2sgaypq 85 10 an an DT cord-313694-p2sgaypq 85 11 RER RER NNP cord-313694-p2sgaypq 85 12 and and CC cord-313694-p2sgaypq 85 13 Golgi Golgi NNP cord-313694-p2sgaypq 85 14 dependent dependent JJ cord-313694-p2sgaypq 85 15 event event NN cord-313694-p2sgaypq 85 16 unless unless IN cord-313694-p2sgaypq 85 17 it -PRON- PRP cord-313694-p2sgaypq 85 18 is be VBZ cord-313694-p2sgaypq 85 19 postulated postulate VBN cord-313694-p2sgaypq 85 20 that that IN cord-313694-p2sgaypq 85 21 modified modify VBN cord-313694-p2sgaypq 85 22 proteins protein NNS cord-313694-p2sgaypq 85 23 subsequently subsequently RB cord-313694-p2sgaypq 85 24 translocate translocate VBP cord-313694-p2sgaypq 85 25 across across IN cord-313694-p2sgaypq 85 26 the the DT cord-313694-p2sgaypq 85 27 membrane membrane NN cord-313694-p2sgaypq 85 28 back back RB cord-313694-p2sgaypq 85 29 to to IN cord-313694-p2sgaypq 85 30 the the DT cord-313694-p2sgaypq 85 31 cytoplasmic cytoplasmic JJ cord-313694-p2sgaypq 85 32 space space NN cord-313694-p2sgaypq 85 33 . . . cord-313694-p2sgaypq 86 1 Further further JJ cord-313694-p2sgaypq 86 2 work work NN cord-313694-p2sgaypq 86 3 remains remain VBZ cord-313694-p2sgaypq 86 4 to to TO cord-313694-p2sgaypq 86 5 be be VB cord-313694-p2sgaypq 86 6 performed perform VBN cord-313694-p2sgaypq 86 7 to to TO cord-313694-p2sgaypq 86 8 confirm confirm VB cord-313694-p2sgaypq 86 9 the the DT cord-313694-p2sgaypq 86 10 existence existence NN cord-313694-p2sgaypq 86 11 of of IN cord-313694-p2sgaypq 86 12 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 86 13 on on IN cord-313694-p2sgaypq 86 14 these these DT cord-313694-p2sgaypq 86 15 proteins protein NNS cord-313694-p2sgaypq 86 16 and and CC cord-313694-p2sgaypq 86 17 to to TO cord-313694-p2sgaypq 86 18 characterize characterize VB cord-313694-p2sgaypq 86 19 their -PRON- PRP$ cord-313694-p2sgaypq 86 20 structure structure NN cord-313694-p2sgaypq 86 21 as as IN cord-313694-p2sgaypq 86 22 a a DT cord-313694-p2sgaypq 86 23 means means NN cord-313694-p2sgaypq 86 24 for for IN cord-313694-p2sgaypq 86 25 understanding understand VBG cord-313694-p2sgaypq 86 26 their -PRON- PRP$ cord-313694-p2sgaypq 86 27 enzymatic enzymatic JJ cord-313694-p2sgaypq 86 28 basis basis NN cord-313694-p2sgaypq 86 29 . . . cord-313694-p2sgaypq 87 1 It -PRON- PRP cord-313694-p2sgaypq 87 2 must must MD cord-313694-p2sgaypq 87 3 be be VB cord-313694-p2sgaypq 87 4 appreciated appreciate VBN cord-313694-p2sgaypq 87 5 that that IN cord-313694-p2sgaypq 87 6 the the DT cord-313694-p2sgaypq 87 7 description description NN cord-313694-p2sgaypq 87 8 of of IN cord-313694-p2sgaypq 87 9 the the DT cord-313694-p2sgaypq 87 10 glycosylation glycosylation NN cord-313694-p2sgaypq 87 11 pathway pathway NN cord-313694-p2sgaypq 87 12 as as IN cord-313694-p2sgaypq 87 13 we -PRON- PRP cord-313694-p2sgaypq 87 14 now now RB cord-313694-p2sgaypq 87 15 understand understand VBP cord-313694-p2sgaypq 87 16 it -PRON- PRP cord-313694-p2sgaypq 87 17 suggests suggest VBZ cord-313694-p2sgaypq 87 18 many many JJ cord-313694-p2sgaypq 87 19 interesting interesting JJ cord-313694-p2sgaypq 87 20 kinds kind NNS cord-313694-p2sgaypq 87 21 of of IN cord-313694-p2sgaypq 87 22 regulatory regulatory JJ cord-313694-p2sgaypq 87 23 mechanisms mechanism NNS cord-313694-p2sgaypq 87 24 . . . cord-313694-p2sgaypq 88 1 For for IN cord-313694-p2sgaypq 88 2 example example NN cord-313694-p2sgaypq 88 3 , , , cord-313694-p2sgaypq 88 4 each each DT cord-313694-p2sgaypq 88 5 step step NN cord-313694-p2sgaypq 88 6 of of IN cord-313694-p2sgaypq 88 7 the the DT cord-313694-p2sgaypq 88 8 pathway pathway NN cord-313694-p2sgaypq 88 9 can can MD cord-313694-p2sgaypq 88 10 be be VB cord-313694-p2sgaypq 88 11 influenced influence VBN cord-313694-p2sgaypq 88 12 by by IN cord-313694-p2sgaypq 88 13 enzyme enzyme NN cord-313694-p2sgaypq 88 14 synthesis synthesis NN cord-313694-p2sgaypq 88 15 and and CC cord-313694-p2sgaypq 88 16 turnover turnover NN cord-313694-p2sgaypq 88 17 , , , cord-313694-p2sgaypq 88 18 acceptor acceptor NN cord-313694-p2sgaypq 88 19 accessibility accessibility NN cord-313694-p2sgaypq 88 20 , , , cord-313694-p2sgaypq 88 21 as as RB cord-313694-p2sgaypq 88 22 well well RB cord-313694-p2sgaypq 88 23 as as IN cord-313694-p2sgaypq 88 24 the the DT cord-313694-p2sgaypq 88 25 supply supply NN cord-313694-p2sgaypq 88 26 of of IN cord-313694-p2sgaypq 88 27 donor donor NN cord-313694-p2sgaypq 88 28 sugar sugar NN cord-313694-p2sgaypq 88 29 , , , cord-313694-p2sgaypq 88 30 cofactors cofactor NNS cord-313694-p2sgaypq 88 31 such such JJ cord-313694-p2sgaypq 88 32 as as IN cord-313694-p2sgaypq 88 33 lipids lipid NNS cord-313694-p2sgaypq 88 34 , , , cord-313694-p2sgaypq 88 35 divalent divalent JJ cord-313694-p2sgaypq 88 36 cations cation NNS cord-313694-p2sgaypq 88 37 , , , cord-313694-p2sgaypq 88 38 etc etc FW cord-313694-p2sgaypq 88 39 . . . cord-313694-p2sgaypq 89 1 The the DT cord-313694-p2sgaypq 89 2 question question NN cord-313694-p2sgaypq 89 3 of of IN cord-313694-p2sgaypq 89 4 accessibility accessibility NN cord-313694-p2sgaypq 89 5 is be VBZ cord-313694-p2sgaypq 89 6 particularly particularly RB cord-313694-p2sgaypq 89 7 interesting interesting JJ cord-313694-p2sgaypq 89 8 because because IN cord-313694-p2sgaypq 89 9 sequentially sequentially RB cord-313694-p2sgaypq 89 10 acting act VBG cord-313694-p2sgaypq 89 11 enzymes enzyme NNS cord-313694-p2sgaypq 89 12 tend tend VBP cord-313694-p2sgaypq 89 13 not not RB cord-313694-p2sgaypq 89 14 to to TO cord-313694-p2sgaypq 89 15 be be VB cord-313694-p2sgaypq 89 16 mixed mix VBN cord-313694-p2sgaypq 89 17 but but CC cord-313694-p2sgaypq 89 18 are be VBP cord-313694-p2sgaypq 89 19 distributed distribute VBN cord-313694-p2sgaypq 89 20 vectorially vectorially RB cord-313694-p2sgaypq 89 21 through through IN cord-313694-p2sgaypq 89 22 the the DT cord-313694-p2sgaypq 89 23 RER rer NN cord-313694-p2sgaypq 89 24 and and CC cord-313694-p2sgaypq 89 25 the the DT cord-313694-p2sgaypq 89 26 multiple multiple JJ cord-313694-p2sgaypq 89 27 compartments compartment NNS cord-313694-p2sgaypq 89 28 of of IN cord-313694-p2sgaypq 89 29 the the DT cord-313694-p2sgaypq 89 30 Golgi Golgi NNP cord-313694-p2sgaypq 89 31 . . . cord-313694-p2sgaypq 90 1 Movement movement NN cord-313694-p2sgaypq 90 2 of of IN cord-313694-p2sgaypq 90 3 polypeptides polypeptide NNS cord-313694-p2sgaypq 90 4 through through IN cord-313694-p2sgaypq 90 5 these these DT cord-313694-p2sgaypq 90 6 compartments compartment NNS cord-313694-p2sgaypq 90 7 appears appear VBZ cord-313694-p2sgaypq 90 8 to to TO cord-313694-p2sgaypq 90 9 be be VB cord-313694-p2sgaypq 90 10 mediated mediate VBN cord-313694-p2sgaypq 90 11 by by IN cord-313694-p2sgaypq 90 12 ATP ATP NNP cord-313694-p2sgaypq 90 13 - - HYPH cord-313694-p2sgaypq 90 14 dependent dependent JJ cord-313694-p2sgaypq 90 15 dissociative dissociative JJ cord-313694-p2sgaypq 90 16 movement movement NN cord-313694-p2sgaypq 90 17 of of IN cord-313694-p2sgaypq 90 18 vesicles vesicle NNS cord-313694-p2sgaypq 90 19 ( ( -LRB- cord-313694-p2sgaypq 90 20 142 142 CD cord-313694-p2sgaypq 90 21 ) ) -RRB- cord-313694-p2sgaypq 90 22 . . . cord-313694-p2sgaypq 91 1 Thus thus RB cord-313694-p2sgaypq 91 2 glycosylation glycosylation NN cord-313694-p2sgaypq 91 3 may may MD cord-313694-p2sgaypq 91 4 conceivably conceivably RB cord-313694-p2sgaypq 91 5 be be VB cord-313694-p2sgaypq 91 6 regulated regulate VBN cord-313694-p2sgaypq 91 7 by by IN cord-313694-p2sgaypq 91 8 the the DT cord-313694-p2sgaypq 91 9 pathway pathway NN cord-313694-p2sgaypq 91 10 of of IN cord-313694-p2sgaypq 91 11 movement movement NN cord-313694-p2sgaypq 91 12 of of IN cord-313694-p2sgaypq 91 13 the the DT cord-313694-p2sgaypq 91 14 acceptor acceptor NN cord-313694-p2sgaypq 91 15 protein protein NN cord-313694-p2sgaypq 91 16 . . . cord-313694-p2sgaypq 92 1 There there EX cord-313694-p2sgaypq 92 2 is be VBZ cord-313694-p2sgaypq 92 3 also also RB cord-313694-p2sgaypq 92 4 an an DT cord-313694-p2sgaypq 92 5 indication indication NN cord-313694-p2sgaypq 92 6 that that IN cord-313694-p2sgaypq 92 7 some some DT cord-313694-p2sgaypq 92 8 glycosyltransferases glycosyltransferase NNS cord-313694-p2sgaypq 92 9 form form NN cord-313694-p2sgaypq 92 10 supramolecular supramolecular JJ cord-313694-p2sgaypq 92 11 complexes complex NNS cord-313694-p2sgaypq 92 12 . . . cord-313694-p2sgaypq 93 1 Thus thus RB cord-313694-p2sgaypq 93 2 , , , cord-313694-p2sgaypq 93 3 it -PRON- PRP cord-313694-p2sgaypq 93 4 is be VBZ cord-313694-p2sgaypq 93 5 possible possible JJ cord-313694-p2sgaypq 93 6 that that IN cord-313694-p2sgaypq 93 7 certain certain JJ cord-313694-p2sgaypq 93 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 93 9 structures structure NNS cord-313694-p2sgaypq 93 10 are be VBP cord-313694-p2sgaypq 93 11 dictated dictate VBN cord-313694-p2sgaypq 93 12 not not RB cord-313694-p2sgaypq 93 13 only only RB cord-313694-p2sgaypq 93 14 by by IN cord-313694-p2sgaypq 93 15 vesicle vesicle NN cord-313694-p2sgaypq 93 16 movement movement NN cord-313694-p2sgaypq 93 17 , , , cord-313694-p2sgaypq 93 18 but but CC cord-313694-p2sgaypq 93 19 also also RB cord-313694-p2sgaypq 93 20 by by IN cord-313694-p2sgaypq 93 21 which which WDT cord-313694-p2sgaypq 93 22 enzyme enzyme NN cord-313694-p2sgaypq 93 23 cluster cluster NN cord-313694-p2sgaypq 93 24 initially initially RB cord-313694-p2sgaypq 93 25 captures capture VBZ cord-313694-p2sgaypq 93 26 the the DT cord-313694-p2sgaypq 93 27 acceptor acceptor NN cord-313694-p2sgaypq 93 28 protein protein NN cord-313694-p2sgaypq 93 29 ( ( -LRB- cord-313694-p2sgaypq 93 30 122 122 CD cord-313694-p2sgaypq 93 31 ) ) -RRB- cord-313694-p2sgaypq 93 32 . . . cord-313694-p2sgaypq 94 1 Ideas idea NNS cord-313694-p2sgaypq 94 2 about about IN cord-313694-p2sgaypq 94 3 the the DT cord-313694-p2sgaypq 94 4 role role NN cord-313694-p2sgaypq 94 5 of of IN cord-313694-p2sgaypq 94 6 protein protein NN cord-313694-p2sgaypq 94 7 glycosylation glycosylation NN cord-313694-p2sgaypq 94 8 may may MD cord-313694-p2sgaypq 94 9 be be VB cord-313694-p2sgaypq 94 10 divided divide VBN cord-313694-p2sgaypq 94 11 into into IN cord-313694-p2sgaypq 94 12 two two CD cord-313694-p2sgaypq 94 13 general general JJ cord-313694-p2sgaypq 94 14 groups group NNS cord-313694-p2sgaypq 94 15 : : : cord-313694-p2sgaypq 94 16 1 1 LS cord-313694-p2sgaypq 94 17 ) ) -RRB- cord-313694-p2sgaypq 94 18 those those DT cord-313694-p2sgaypq 94 19 which which WDT cord-313694-p2sgaypq 94 20 imply imply VBP cord-313694-p2sgaypq 94 21 specificity specificity NN cord-313694-p2sgaypq 94 22 associated associate VBN cord-313694-p2sgaypq 94 23 with with IN cord-313694-p2sgaypq 94 24 particular particular JJ cord-313694-p2sgaypq 94 25 carbohydrate carbohydrate NN cord-313694-p2sgaypq 94 26 structures structure NNS cord-313694-p2sgaypq 94 27 , , , cord-313694-p2sgaypq 94 28 and and CC cord-313694-p2sgaypq 94 29 2 2 LS cord-313694-p2sgaypq 94 30 ) ) -RRB- cord-313694-p2sgaypq 94 31 those those DT cord-313694-p2sgaypq 94 32 which which WDT cord-313694-p2sgaypq 94 33 stress stress VBP cord-313694-p2sgaypq 94 34 the the DT cord-313694-p2sgaypq 94 35 general general JJ cord-313694-p2sgaypq 94 36 similarities similarity NNS cord-313694-p2sgaypq 94 37 of of IN cord-313694-p2sgaypq 94 38 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 94 39 structures structure NNS cord-313694-p2sgaypq 94 40 , , , cord-313694-p2sgaypq 94 41 and and CC cord-313694-p2sgaypq 94 42 the the DT cord-313694-p2sgaypq 94 43 presence presence NN cord-313694-p2sgaypq 94 44 of of IN cord-313694-p2sgaypq 94 45 microheterogeneity microheterogeneity NN cord-313694-p2sgaypq 94 46 in in IN cord-313694-p2sgaypq 94 47 the the DT cord-313694-p2sgaypq 94 48 structure structure NN cord-313694-p2sgaypq 94 49 of of IN cord-313694-p2sgaypq 94 50 particular particular JJ cord-313694-p2sgaypq 94 51 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 94 52 , , , cord-313694-p2sgaypq 94 53 in in IN cord-313694-p2sgaypq 94 54 suggesting suggest VBG cord-313694-p2sgaypq 94 55 that that IN cord-313694-p2sgaypq 94 56 combined combine VBN cord-313694-p2sgaypq 94 57 carbohydrate carbohydrate NN cord-313694-p2sgaypq 94 58 bulk bulk NN cord-313694-p2sgaypq 94 59 creates create VBZ cord-313694-p2sgaypq 94 60 a a DT cord-313694-p2sgaypq 94 61 common common JJ cord-313694-p2sgaypq 94 62 microenvironment microenvironment NN cord-313694-p2sgaypq 94 63 for for IN cord-313694-p2sgaypq 94 64 resident resident JJ cord-313694-p2sgaypq 94 65 polypeptides polypeptide NNS cord-313694-p2sgaypq 94 66 much much RB cord-313694-p2sgaypq 94 67 as as IN cord-313694-p2sgaypq 94 68 the the DT cord-313694-p2sgaypq 94 69 lipid lipid NN cord-313694-p2sgaypq 94 70 bilayer bilayer NN cord-313694-p2sgaypq 94 71 provides provide VBZ cord-313694-p2sgaypq 94 72 an an DT cord-313694-p2sgaypq 94 73 environment environment NN cord-313694-p2sgaypq 94 74 for for IN cord-313694-p2sgaypq 94 75 integral integral JJ cord-313694-p2sgaypq 94 76 membrane membrane NN cord-313694-p2sgaypq 94 77 proteins protein NNS cord-313694-p2sgaypq 94 78 . . . cord-313694-p2sgaypq 95 1 Most Most JJS cord-313694-p2sgaypq 95 2 effort effort NN cord-313694-p2sgaypq 95 3 has have VBZ cord-313694-p2sgaypq 95 4 been be VBN cord-313694-p2sgaypq 95 5 devoted devote VBN cord-313694-p2sgaypq 95 6 to to IN cord-313694-p2sgaypq 95 7 the the DT cord-313694-p2sgaypq 95 8 former former JJ cord-313694-p2sgaypq 95 9 category category NN cord-313694-p2sgaypq 95 10 of of IN cord-313694-p2sgaypq 95 11 ideas idea NNS cord-313694-p2sgaypq 95 12 because because IN cord-313694-p2sgaypq 95 13 of of IN cord-313694-p2sgaypq 95 14 the the DT cord-313694-p2sgaypq 95 15 greater great JJR cord-313694-p2sgaypq 95 16 ease ease NN cord-313694-p2sgaypq 95 17 of of IN cord-313694-p2sgaypq 95 18 formulating formulate VBG cord-313694-p2sgaypq 95 19 hypotheses hypothesis NNS cord-313694-p2sgaypq 95 20 of of IN cord-313694-p2sgaypq 95 21 this this DT cord-313694-p2sgaypq 95 22 type type NN cord-313694-p2sgaypq 95 23 . . . cord-313694-p2sgaypq 96 1 A a DT cord-313694-p2sgaypq 96 2 non non JJ cord-313694-p2sgaypq 96 3 - - JJ cord-313694-p2sgaypq 96 4 specific specific JJ cord-313694-p2sgaypq 96 5 role role NN cord-313694-p2sgaypq 96 6 for for IN cord-313694-p2sgaypq 96 7 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 96 8 that that WDT cord-313694-p2sgaypq 96 9 is be VBZ cord-313694-p2sgaypq 96 10 dependent dependent JJ cord-313694-p2sgaypq 96 11 on on IN cord-313694-p2sgaypq 96 12 their -PRON- PRP$ cord-313694-p2sgaypq 96 13 generalized generalized JJ cord-313694-p2sgaypq 96 14 chemical chemical NN cord-313694-p2sgaypq 96 15 properties property NNS cord-313694-p2sgaypq 96 16 has have VBZ cord-313694-p2sgaypq 96 17 been be VBN cord-313694-p2sgaypq 96 18 suggested suggest VBN cord-313694-p2sgaypq 96 19 in in IN cord-313694-p2sgaypq 96 20 several several JJ cord-313694-p2sgaypq 96 21 contexts context NNS cord-313694-p2sgaypq 96 22 . . . cord-313694-p2sgaypq 97 1 It -PRON- PRP cord-313694-p2sgaypq 97 2 was be VBD cord-313694-p2sgaypq 97 3 appreciated appreciate VBN cord-313694-p2sgaypq 97 4 early early RB cord-313694-p2sgaypq 97 5 on on IN cord-313694-p2sgaypq 97 6 that that DT cord-313694-p2sgaypq 97 7 carbohydrate carbohydrate NN cord-313694-p2sgaypq 97 8 afforded afford VBD cord-313694-p2sgaypq 97 9 a a DT cord-313694-p2sgaypq 97 10 stabilizing stabilize VBG cord-313694-p2sgaypq 97 11 effect effect NN cord-313694-p2sgaypq 97 12 on on IN cord-313694-p2sgaypq 97 13 protein protein NN cord-313694-p2sgaypq 97 14 solubility solubility NN cord-313694-p2sgaypq 97 15 and and CC cord-313694-p2sgaypq 97 16 against against IN cord-313694-p2sgaypq 97 17 heat heat NN cord-313694-p2sgaypq 97 18 denaturation denaturation NNP cord-313694-p2sgaypq 97 19 ( ( -LRB- cord-313694-p2sgaypq 97 20 see see UH cord-313694-p2sgaypq 97 21 , , , cord-313694-p2sgaypq 97 22 e.g. e.g. RB cord-313694-p2sgaypq 97 23 34 34 CD cord-313694-p2sgaypq 97 24 , , , cord-313694-p2sgaypq 97 25 38 38 CD cord-313694-p2sgaypq 97 26 and and CC cord-313694-p2sgaypq 97 27 35 35 CD cord-313694-p2sgaypq 97 28 ) ) -RRB- cord-313694-p2sgaypq 97 29 . . . cord-313694-p2sgaypq 98 1 It -PRON- PRP cord-313694-p2sgaypq 98 2 was be VBD cord-313694-p2sgaypq 98 3 also also RB cord-313694-p2sgaypq 98 4 realized realize VBN cord-313694-p2sgaypq 98 5 that that IN cord-313694-p2sgaypq 98 6 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 98 7 afford afford VBP cord-313694-p2sgaypq 98 8 resistance resistance NN cord-313694-p2sgaypq 98 9 to to IN cord-313694-p2sgaypq 98 10 proteolytic proteolytic JJ cord-313694-p2sgaypq 98 11 degradation degradation NN cord-313694-p2sgaypq 98 12 ( ( -LRB- cord-313694-p2sgaypq 98 13 166 166 CD cord-313694-p2sgaypq 98 14 ) ) -RRB- cord-313694-p2sgaypq 98 15 , , , cord-313694-p2sgaypq 98 16 presumably presumably RB cord-313694-p2sgaypq 98 17 by by IN cord-313694-p2sgaypq 98 18 a a DT cord-313694-p2sgaypq 98 19 mechanism mechanism NN cord-313694-p2sgaypq 98 20 of of IN cord-313694-p2sgaypq 98 21 steric steric JJ cord-313694-p2sgaypq 98 22 hindrance hindrance NN cord-313694-p2sgaypq 98 23 , , , cord-313694-p2sgaypq 98 24 and and CC cord-313694-p2sgaypq 98 25 these these DT cord-313694-p2sgaypq 98 26 ideas idea NNS cord-313694-p2sgaypq 98 27 have have VBP cord-313694-p2sgaypq 98 28 been be VBN cord-313694-p2sgaypq 98 29 reinforced reinforce VBN cord-313694-p2sgaypq 98 30 in in IN cord-313694-p2sgaypq 98 31 numerous numerous JJ cord-313694-p2sgaypq 98 32 studies study NNS cord-313694-p2sgaypq 98 33 up up IN cord-313694-p2sgaypq 98 34 to to IN cord-313694-p2sgaypq 98 35 the the DT cord-313694-p2sgaypq 98 36 present present NN cord-313694-p2sgaypq 98 37 ( ( -LRB- cord-313694-p2sgaypq 98 38 e.g. e.g. RB cord-313694-p2sgaypq 98 39 , , , cord-313694-p2sgaypq 98 40 12 12 CD cord-313694-p2sgaypq 98 41 , , , cord-313694-p2sgaypq 98 42 101 101 CD cord-313694-p2sgaypq 98 43 , , , cord-313694-p2sgaypq 98 44 102 102 CD cord-313694-p2sgaypq 98 45 ) ) -RRB- cord-313694-p2sgaypq 98 46 . . . cord-313694-p2sgaypq 99 1 There there EX cord-313694-p2sgaypq 99 2 are be VBP cord-313694-p2sgaypq 99 3 in in IN cord-313694-p2sgaypq 99 4 addition addition NN cord-313694-p2sgaypq 99 5 several several JJ cord-313694-p2sgaypq 99 6 instances instance NNS cord-313694-p2sgaypq 99 7 where where WRB cord-313694-p2sgaypq 99 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 99 9 is be VBZ cord-313694-p2sgaypq 99 10 known know VBN cord-313694-p2sgaypq 99 11 to to TO cord-313694-p2sgaypq 99 12 interfere interfere VB cord-313694-p2sgaypq 99 13 sterically sterically RB cord-313694-p2sgaypq 99 14 with with IN cord-313694-p2sgaypq 99 15 protein protein NN cord-313694-p2sgaypq 99 16 - - HYPH cord-313694-p2sgaypq 99 17 protein protein NN cord-313694-p2sgaypq 99 18 interaction interaction NN cord-313694-p2sgaypq 99 19 not not RB cord-313694-p2sgaypq 99 20 involving involve VBG cord-313694-p2sgaypq 99 21 proteolysis proteolysis NN cord-313694-p2sgaypq 99 22 ( ( -LRB- cord-313694-p2sgaypq 99 23 74 74 CD cord-313694-p2sgaypq 99 24 , , , cord-313694-p2sgaypq 99 25 75 75 CD cord-313694-p2sgaypq 99 26 ) ) -RRB- cord-313694-p2sgaypq 99 27 . . . cord-313694-p2sgaypq 100 1 Predating predate VBG cord-313694-p2sgaypq 100 2 this this DT cord-313694-p2sgaypq 100 3 understanding understanding NN cord-313694-p2sgaypq 100 4 , , , cord-313694-p2sgaypq 100 5 it -PRON- PRP cord-313694-p2sgaypq 100 6 was be VBD cord-313694-p2sgaypq 100 7 known know VBN cord-313694-p2sgaypq 100 8 that that IN cord-313694-p2sgaypq 100 9 carbohydrate carbohydrate NN cord-313694-p2sgaypq 100 10 is be VBZ cord-313694-p2sgaypq 100 11 a a DT cord-313694-p2sgaypq 100 12 major major JJ cord-313694-p2sgaypq 100 13 constituent constituent NN cord-313694-p2sgaypq 100 14 of of IN cord-313694-p2sgaypq 100 15 the the DT cord-313694-p2sgaypq 100 16 extracellular extracellular JJ cord-313694-p2sgaypq 100 17 matrix matrix NN cord-313694-p2sgaypq 100 18 in in IN cord-313694-p2sgaypq 100 19 the the DT cord-313694-p2sgaypq 100 20 form form NN cord-313694-p2sgaypq 100 21 of of IN cord-313694-p2sgaypq 100 22 polysaccharides polysaccharide NNS cord-313694-p2sgaypq 100 23 known know VBN cord-313694-p2sgaypq 100 24 as as IN cord-313694-p2sgaypq 100 25 glycosaminoglycans glycosaminoglycan NNS cord-313694-p2sgaypq 100 26 ( ( -LRB- cord-313694-p2sgaypq 100 27 GAGs GAGs NNP cord-313694-p2sgaypq 100 28 ) ) -RRB- cord-313694-p2sgaypq 100 29 ( ( -LRB- cord-313694-p2sgaypq 100 30 3 3 CD cord-313694-p2sgaypq 100 31 ) ) -RRB- cord-313694-p2sgaypq 100 32 . . . cord-313694-p2sgaypq 101 1 In in IN cord-313694-p2sgaypq 101 2 the the DT cord-313694-p2sgaypq 101 3 past past JJ cord-313694-p2sgaypq 101 4 15 15 CD cord-313694-p2sgaypq 101 5 years year NNS cord-313694-p2sgaypq 101 6 , , , cord-313694-p2sgaypq 101 7 it -PRON- PRP cord-313694-p2sgaypq 101 8 has have VBZ cord-313694-p2sgaypq 101 9 been be VBN cord-313694-p2sgaypq 101 10 discovered discover VBN cord-313694-p2sgaypq 101 11 that that IN cord-313694-p2sgaypq 101 12 most most JJS cord-313694-p2sgaypq 101 13 GAGs gag NNS cord-313694-p2sgaypq 101 14 are be VBP cord-313694-p2sgaypq 101 15 covalently covalently RB cord-313694-p2sgaypq 101 16 attached attach VBN cord-313694-p2sgaypq 101 17 to to IN cord-313694-p2sgaypq 101 18 polypeptides polypeptide NNS cord-313694-p2sgaypq 101 19 , , , cord-313694-p2sgaypq 101 20 resulting result VBG cord-313694-p2sgaypq 101 21 in in IN cord-313694-p2sgaypq 101 22 the the DT cord-313694-p2sgaypq 101 23 formation formation NN cord-313694-p2sgaypq 101 24 of of IN cord-313694-p2sgaypq 101 25 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 101 26 which which WDT cord-313694-p2sgaypq 101 27 , , , cord-313694-p2sgaypq 101 28 due due IN cord-313694-p2sgaypq 101 29 to to IN cord-313694-p2sgaypq 101 30 the the DT cord-313694-p2sgaypq 101 31 specialized specialized JJ cord-313694-p2sgaypq 101 32 nature nature NN cord-313694-p2sgaypq 101 33 of of IN cord-313694-p2sgaypq 101 34 the the DT cord-313694-p2sgaypq 101 35 attached attach VBN cord-313694-p2sgaypq 101 36 carbohydrate carbohydrate NN cord-313694-p2sgaypq 101 37 , , , cord-313694-p2sgaypq 101 38 are be VBP cord-313694-p2sgaypq 101 39 known know VBN cord-313694-p2sgaypq 101 40 as as IN cord-313694-p2sgaypq 101 41 proteoglycans proteoglycan NNS cord-313694-p2sgaypq 101 42 . . . cord-313694-p2sgaypq 102 1 GAGs gag NNS cord-313694-p2sgaypq 102 2 are be VBP cord-313694-p2sgaypq 102 3 anionic anionic JJ cord-313694-p2sgaypq 102 4 polymers polymer NNS cord-313694-p2sgaypq 102 5 which which WDT cord-313694-p2sgaypq 102 6 hydrate hydrate VBP cord-313694-p2sgaypq 102 7 to to TO cord-313694-p2sgaypq 102 8 form form VB cord-313694-p2sgaypq 102 9 enlarged enlarged JJ cord-313694-p2sgaypq 102 10 domains domain NNS cord-313694-p2sgaypq 102 11 which which WDT cord-313694-p2sgaypq 102 12 can can MD cord-313694-p2sgaypq 102 13 interact interact VB cord-313694-p2sgaypq 102 14 with with IN cord-313694-p2sgaypq 102 15 one one CD cord-313694-p2sgaypq 102 16 another another DT cord-313694-p2sgaypq 102 17 , , , cord-313694-p2sgaypq 102 18 as as RB cord-313694-p2sgaypq 102 19 well well RB cord-313694-p2sgaypq 102 20 as as IN cord-313694-p2sgaypq 102 21 with with IN cord-313694-p2sgaypq 102 22 polycationic polycationic NNP cord-313694-p2sgaypq 102 23 polymers polymer NNS cord-313694-p2sgaypq 102 24 such such JJ cord-313694-p2sgaypq 102 25 as as IN cord-313694-p2sgaypq 102 26 collagen collagen NN cord-313694-p2sgaypq 102 27 and and CC cord-313694-p2sgaypq 102 28 with with IN cord-313694-p2sgaypq 102 29 other other JJ cord-313694-p2sgaypq 102 30 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 102 31 ( ( -LRB- cord-313694-p2sgaypq 102 32 3 3 CD cord-313694-p2sgaypq 102 33 ) ) -RRB- cord-313694-p2sgaypq 102 34 . . . cord-313694-p2sgaypq 103 1 A a DT cord-313694-p2sgaypq 103 2 three three CD cord-313694-p2sgaypq 103 3 dimensional dimensional JJ cord-313694-p2sgaypq 103 4 space space NN cord-313694-p2sgaypq 103 5 is be VBZ cord-313694-p2sgaypq 103 6 thus thus RB cord-313694-p2sgaypq 103 7 defined define VBN cord-313694-p2sgaypq 103 8 by by IN cord-313694-p2sgaypq 103 9 polysaccharide polysaccharide NN cord-313694-p2sgaypq 103 10 , , , cord-313694-p2sgaypq 103 11 protein protein NN cord-313694-p2sgaypq 103 12 , , , cord-313694-p2sgaypq 103 13 and and CC cord-313694-p2sgaypq 103 14 the the DT cord-313694-p2sgaypq 103 15 bound bound JJ cord-313694-p2sgaypq 103 16 water water NN cord-313694-p2sgaypq 103 17 which which WDT cord-313694-p2sgaypq 103 18 provides provide VBZ cord-313694-p2sgaypq 103 19 an an DT cord-313694-p2sgaypq 103 20 environment environment NN cord-313694-p2sgaypq 103 21 for for IN cord-313694-p2sgaypq 103 22 cells cell NNS cord-313694-p2sgaypq 103 23 . . . cord-313694-p2sgaypq 104 1 Convection convection NN cord-313694-p2sgaypq 104 2 and and CC cord-313694-p2sgaypq 104 3 diffusion diffusion NN cord-313694-p2sgaypq 104 4 are be VBP cord-313694-p2sgaypq 104 5 modified modify VBN cord-313694-p2sgaypq 104 6 , , , cord-313694-p2sgaypq 104 7 and and CC cord-313694-p2sgaypq 104 8 fluctuations fluctuation NNS cord-313694-p2sgaypq 104 9 in in IN cord-313694-p2sgaypq 104 10 ionic ionic JJ cord-313694-p2sgaypq 104 11 strength strength NN cord-313694-p2sgaypq 104 12 and and CC cord-313694-p2sgaypq 104 13 pH pH NNP cord-313694-p2sgaypq 104 14 are be VBP cord-313694-p2sgaypq 104 15 minimized minimize VBN cord-313694-p2sgaypq 104 16 . . . cord-313694-p2sgaypq 105 1 These these DT cord-313694-p2sgaypq 105 2 structures structure NNS cord-313694-p2sgaypq 105 3 depend depend VBP cord-313694-p2sgaypq 105 4 on on IN cord-313694-p2sgaypq 105 5 the the DT cord-313694-p2sgaypq 105 6 polyanionic polyanionic JJ cord-313694-p2sgaypq 105 7 nature nature NN cord-313694-p2sgaypq 105 8 of of IN cord-313694-p2sgaypq 105 9 the the DT cord-313694-p2sgaypq 105 10 carbohydrate carbohydrate NN cord-313694-p2sgaypq 105 11 , , , cord-313694-p2sgaypq 105 12 and and CC cord-313694-p2sgaypq 105 13 the the DT cord-313694-p2sgaypq 105 14 general general JJ cord-313694-p2sgaypq 105 15 chemistry chemistry NN cord-313694-p2sgaypq 105 16 rather rather RB cord-313694-p2sgaypq 105 17 than than IN cord-313694-p2sgaypq 105 18 the the DT cord-313694-p2sgaypq 105 19 specific specific JJ cord-313694-p2sgaypq 105 20 monosaccharide monosaccharide NN cord-313694-p2sgaypq 105 21 identities identity NNS cord-313694-p2sgaypq 105 22 and and CC cord-313694-p2sgaypq 105 23 sequences sequence NNS cord-313694-p2sgaypq 105 24 may may MD cord-313694-p2sgaypq 105 25 be be VB cord-313694-p2sgaypq 105 26 dominant dominant JJ cord-313694-p2sgaypq 105 27 in in IN cord-313694-p2sgaypq 105 28 governing govern VBG cord-313694-p2sgaypq 105 29 the the DT cord-313694-p2sgaypq 105 30 properties property NNS cord-313694-p2sgaypq 105 31 of of IN cord-313694-p2sgaypq 105 32 the the DT cord-313694-p2sgaypq 105 33 system system NN cord-313694-p2sgaypq 105 34 . . . cord-313694-p2sgaypq 106 1 Carbohydrate carbohydrate NN cord-313694-p2sgaypq 106 2 oligomers oligomer NNS cord-313694-p2sgaypq 106 3 are be VBP cord-313694-p2sgaypq 106 4 also also RB cord-313694-p2sgaypq 106 5 known know VBN cord-313694-p2sgaypq 106 6 to to IN cord-313694-p2sgaypq 106 7 selfassociate selfassociate VB cord-313694-p2sgaypq 106 8 in in IN cord-313694-p2sgaypq 106 9 the the DT cord-313694-p2sgaypq 106 10 formation formation NN cord-313694-p2sgaypq 106 11 of of IN cord-313694-p2sgaypq 106 12 mucous mucous JJ cord-313694-p2sgaypq 106 13 gels gel NNS cord-313694-p2sgaypq 106 14 and and CC cord-313694-p2sgaypq 106 15 in in IN cord-313694-p2sgaypq 106 16 yeast yeast NN cord-313694-p2sgaypq 106 17 and and CC cord-313694-p2sgaypq 106 18 plant plant NN cord-313694-p2sgaypq 106 19 cell cell NN cord-313694-p2sgaypq 106 20 walls wall NNS cord-313694-p2sgaypq 106 21 ( ( -LRB- cord-313694-p2sgaypq 106 22 152 152 CD cord-313694-p2sgaypq 106 23 ) ) -RRB- cord-313694-p2sgaypq 106 24 ( ( -LRB- cord-313694-p2sgaypq 106 25 153 153 CD cord-313694-p2sgaypq 106 26 ) ) -RRB- cord-313694-p2sgaypq 106 27 ( ( -LRB- cord-313694-p2sgaypq 106 28 154 154 CD cord-313694-p2sgaypq 106 29 ) ) -RRB- cord-313694-p2sgaypq 106 30 22 22 CD cord-313694-p2sgaypq 106 31 ) ) -RRB- cord-313694-p2sgaypq 106 32 . . . cord-313694-p2sgaypq 107 1 In in IN cord-313694-p2sgaypq 107 2 the the DT cord-313694-p2sgaypq 107 3 former former JJ cord-313694-p2sgaypq 107 4 , , , cord-313694-p2sgaypq 107 5 the the DT cord-313694-p2sgaypq 107 6 anionic anionic JJ cord-313694-p2sgaypq 107 7 nature nature NN cord-313694-p2sgaypq 107 8 of of IN cord-313694-p2sgaypq 107 9 the the DT cord-313694-p2sgaypq 107 10 carbohydrate carbohydrate NN cord-313694-p2sgaypq 107 11 appears appear VBZ cord-313694-p2sgaypq 107 12 to to TO cord-313694-p2sgaypq 107 13 be be VB cord-313694-p2sgaypq 107 14 important important JJ cord-313694-p2sgaypq 107 15 although although IN cord-313694-p2sgaypq 107 16 in in IN cord-313694-p2sgaypq 107 17 the the DT cord-313694-p2sgaypq 107 18 algal algal NN cord-313694-p2sgaypq 107 19 and and CC cord-313694-p2sgaypq 107 20 yeast yeast NN cord-313694-p2sgaypq 107 21 gels gel NNS cord-313694-p2sgaypq 107 22 the the DT cord-313694-p2sgaypq 107 23 interactions interaction NNS cord-313694-p2sgaypq 107 24 are be VBP cord-313694-p2sgaypq 107 25 non non JJ cord-313694-p2sgaypq 107 26 - - JJ cord-313694-p2sgaypq 107 27 coulombic coulombic JJ cord-313694-p2sgaypq 107 28 . . . cord-313694-p2sgaypq 108 1 The the DT cord-313694-p2sgaypq 108 2 collective collective JJ cord-313694-p2sgaypq 108 3 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 108 4 density density NN cord-313694-p2sgaypq 108 5 on on IN cord-313694-p2sgaypq 108 6 cell cell NN cord-313694-p2sgaypq 108 7 surface surface NN cord-313694-p2sgaypq 108 8 proteins protein NNS cord-313694-p2sgaypq 108 9 is be VBZ cord-313694-p2sgaypq 108 10 sufficiently sufficiently RB cord-313694-p2sgaypq 108 11 great great JJ cord-313694-p2sgaypq 108 12 so so IN cord-313694-p2sgaypq 108 13 as as IN cord-313694-p2sgaypq 108 14 to to TO cord-313694-p2sgaypq 108 15 invite invite VB cord-313694-p2sgaypq 108 16 comparison comparison NN cord-313694-p2sgaypq 108 17 with with IN cord-313694-p2sgaypq 108 18 the the DT cord-313694-p2sgaypq 108 19 carbohydrate carbohydrate NN cord-313694-p2sgaypq 108 20 density density NN cord-313694-p2sgaypq 108 21 of of IN cord-313694-p2sgaypq 108 22 the the DT cord-313694-p2sgaypq 108 23 matrix matrix NN cord-313694-p2sgaypq 108 24 space space NN cord-313694-p2sgaypq 108 25 . . . cord-313694-p2sgaypq 109 1 This this DT cord-313694-p2sgaypq 109 2 observation observation NN cord-313694-p2sgaypq 109 3 has have VBZ cord-313694-p2sgaypq 109 4 led lead VBN cord-313694-p2sgaypq 109 5 to to IN cord-313694-p2sgaypq 109 6 the the DT cord-313694-p2sgaypq 109 7 suggestion suggestion NN cord-313694-p2sgaypq 109 8 that that IN cord-313694-p2sgaypq 109 9 cell cell NN cord-313694-p2sgaypq 109 10 surface surface NN cord-313694-p2sgaypq 109 11 carbohydrate carbohydrate NN cord-313694-p2sgaypq 109 12 might may MD cord-313694-p2sgaypq 109 13 also also RB cord-313694-p2sgaypq 109 14 establish establish VB cord-313694-p2sgaypq 109 15 a a DT cord-313694-p2sgaypq 109 16 convection convection NN cord-313694-p2sgaypq 109 17 and and CC cord-313694-p2sgaypq 109 18 diffusionqimited diffusionqimited JJ cord-313694-p2sgaypq 109 19 region region NN cord-313694-p2sgaypq 109 20 around around IN cord-313694-p2sgaypq 109 21 the the DT cord-313694-p2sgaypq 109 22 cell cell NN cord-313694-p2sgaypq 109 23 in in IN cord-313694-p2sgaypq 109 24 an an DT cord-313694-p2sgaypq 109 25 area area NN cord-313694-p2sgaypq 109 26 thick thick JJ cord-313694-p2sgaypq 109 27 enough enough RB cord-313694-p2sgaypq 109 28 to to TO cord-313694-p2sgaypq 109 29 be be VB cord-313694-p2sgaypq 109 30 named name VBN cord-313694-p2sgaypq 109 31 , , , cord-313694-p2sgaypq 109 32 in in IN cord-313694-p2sgaypq 109 33 certain certain JJ cord-313694-p2sgaypq 109 34 cell cell NN cord-313694-p2sgaypq 109 35 types type NNS cord-313694-p2sgaypq 109 36 , , , cord-313694-p2sgaypq 109 37 the the DT cord-313694-p2sgaypq 109 38 glycocalyx glycocalyx NNP cord-313694-p2sgaypq 109 39 or or CC cord-313694-p2sgaypq 109 40 fuzz fuzz NN cord-313694-p2sgaypq 109 41 . . . cord-313694-p2sgaypq 110 1 The the DT cord-313694-p2sgaypq 110 2 polyanionic polyanionic JJ cord-313694-p2sgaypq 110 3 nature nature NN cord-313694-p2sgaypq 110 4 of of IN cord-313694-p2sgaypq 110 5 the the DT cord-313694-p2sgaypq 110 6 carbohydrate carbohydrate NN cord-313694-p2sgaypq 110 7 found find VBN cord-313694-p2sgaypq 110 8 on on IN cord-313694-p2sgaypq 110 9 some some DT cord-313694-p2sgaypq 110 10 cell cell NN cord-313694-p2sgaypq 110 11 surfaces surface NNS cord-313694-p2sgaypq 110 12 probably probably RB cord-313694-p2sgaypq 110 13 results result VBZ cord-313694-p2sgaypq 110 14 in in IN cord-313694-p2sgaypq 110 15 marked marked JJ cord-313694-p2sgaypq 110 16 cation cation NN cord-313694-p2sgaypq 110 17 and and CC cord-313694-p2sgaypq 110 18 pH pH NNP cord-313694-p2sgaypq 110 19 differences difference NNS cord-313694-p2sgaypq 110 20 in in IN cord-313694-p2sgaypq 110 21 this this DT cord-313694-p2sgaypq 110 22 region region NN cord-313694-p2sgaypq 110 23 relative relative JJ cord-313694-p2sgaypq 110 24 to to IN cord-313694-p2sgaypq 110 25 the the DT cord-313694-p2sgaypq 110 26 surrounding surround VBG cord-313694-p2sgaypq 110 27 medium medium NN cord-313694-p2sgaypq 110 28 ( ( -LRB- cord-313694-p2sgaypq 110 29 177 177 CD cord-313694-p2sgaypq 110 30 ) ) -RRB- cord-313694-p2sgaypq 110 31 . . . cord-313694-p2sgaypq 111 1 It -PRON- PRP cord-313694-p2sgaypq 111 2 has have VBZ cord-313694-p2sgaypq 111 3 recently recently RB cord-313694-p2sgaypq 111 4 been be VBN cord-313694-p2sgaypq 111 5 proposed propose VBN cord-313694-p2sgaypq 111 6 that that IN cord-313694-p2sgaypq 111 7 the the DT cord-313694-p2sgaypq 111 8 heterogeneity heterogeneity NN cord-313694-p2sgaypq 111 9 of of IN cord-313694-p2sgaypq 111 10 carbohydrate carbohydrate NN cord-313694-p2sgaypq 111 11 structure structure NN cord-313694-p2sgaypq 111 12 found find VBN cord-313694-p2sgaypq 111 13 on on IN cord-313694-p2sgaypq 111 14 proteins protein NNS cord-313694-p2sgaypq 111 15 of of IN cord-313694-p2sgaypq 111 16 this this DT cord-313694-p2sgaypq 111 17 region region NN cord-313694-p2sgaypq 111 18 might may MD cord-313694-p2sgaypq 111 19 result result VB cord-313694-p2sgaypq 111 20 in in IN cord-313694-p2sgaypq 111 21 minor minor JJ cord-313694-p2sgaypq 111 22 differences difference NNS cord-313694-p2sgaypq 111 23 in in IN cord-313694-p2sgaypq 111 24 protein protein NN cord-313694-p2sgaypq 111 25 function function NN cord-313694-p2sgaypq 111 26 , , , cord-313694-p2sgaypq 111 27 leading lead VBG cord-313694-p2sgaypq 111 28 to to IN cord-313694-p2sgaypq 111 29 a a DT cord-313694-p2sgaypq 111 30 broader broad JJR cord-313694-p2sgaypq 111 31 range range NN cord-313694-p2sgaypq 111 32 in in IN cord-313694-p2sgaypq 111 33 the the DT cord-313694-p2sgaypq 111 34 ionic ionic JJ cord-313694-p2sgaypq 111 35 strength strength NN cord-313694-p2sgaypq 111 36 and and CC cord-313694-p2sgaypq 111 37 pH ph NN cord-313694-p2sgaypq 111 38 values value NNS cord-313694-p2sgaypq 111 39 optimal optimal JJ cord-313694-p2sgaypq 111 40 for for IN cord-313694-p2sgaypq 111 41 protein protein NN cord-313694-p2sgaypq 111 42 function function NN cord-313694-p2sgaypq 111 43 ( ( -LRB- cord-313694-p2sgaypq 111 44 36 36 CD cord-313694-p2sgaypq 111 45 , , , cord-313694-p2sgaypq 111 46 37 37 CD cord-313694-p2sgaypq 111 47 ) ) -RRB- cord-313694-p2sgaypq 111 48 . . . cord-313694-p2sgaypq 112 1 As as IN cord-313694-p2sgaypq 112 2 such such JJ cord-313694-p2sgaypq 112 3 , , , cord-313694-p2sgaypq 112 4 protein protein NN cord-313694-p2sgaypq 112 5 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 112 6 might may MD cord-313694-p2sgaypq 112 7 subserve subserve VB cord-313694-p2sgaypq 112 8 a a DT cord-313694-p2sgaypq 112 9 homeostatic homeostatic JJ cord-313694-p2sgaypq 112 10 process process NN cord-313694-p2sgaypq 112 11 used use VBN cord-313694-p2sgaypq 112 12 by by IN cord-313694-p2sgaypq 112 13 cells cell NNS cord-313694-p2sgaypq 112 14 to to TO cord-313694-p2sgaypq 112 15 maintain maintain VB cord-313694-p2sgaypq 112 16 their -PRON- PRP$ cord-313694-p2sgaypq 112 17 viability viability NN cord-313694-p2sgaypq 112 18 in in IN cord-313694-p2sgaypq 112 19 potentially potentially RB cord-313694-p2sgaypq 112 20 changing change VBG cord-313694-p2sgaypq 112 21 milieus milieu NNS cord-313694-p2sgaypq 112 22 . . . cord-313694-p2sgaypq 113 1 It -PRON- PRP cord-313694-p2sgaypq 113 2 has have VBZ cord-313694-p2sgaypq 113 3 also also RB cord-313694-p2sgaypq 113 4 been be VBN cord-313694-p2sgaypq 113 5 suggested suggest VBN cord-313694-p2sgaypq 113 6 that that IN cord-313694-p2sgaypq 113 7 a a DT cord-313694-p2sgaypq 113 8 layer layer NN cord-313694-p2sgaypq 113 9 of of IN cord-313694-p2sgaypq 113 10 non non JJ cord-313694-p2sgaypq 113 11 - - JJ cord-313694-p2sgaypq 113 12 immunogenic immunogenic JJ cord-313694-p2sgaypq 113 13 protein protein NN cord-313694-p2sgaypq 113 14 - - HYPH cord-313694-p2sgaypq 113 15 associated associate VBN cord-313694-p2sgaypq 113 16 carbohydrate carbohydrate NN cord-313694-p2sgaypq 113 17 may may MD cord-313694-p2sgaypq 113 18 play play VB cord-313694-p2sgaypq 113 19 an an DT cord-313694-p2sgaypq 113 20 immuno immuno JJ cord-313694-p2sgaypq 113 21 - - JJ cord-313694-p2sgaypq 113 22 protective protective JJ cord-313694-p2sgaypq 113 23 role role NN cord-313694-p2sgaypq 113 24 for for IN cord-313694-p2sgaypq 113 25 underlying underlie VBG cord-313694-p2sgaypq 113 26 cell cell NN cord-313694-p2sgaypq 113 27 surface surface NN cord-313694-p2sgaypq 113 28 antigens antigen NNS cord-313694-p2sgaypq 113 29 , , , cord-313694-p2sgaypq 113 30 especially especially RB cord-313694-p2sgaypq 113 31 on on IN cord-313694-p2sgaypq 113 32 neoplastic neoplastic JJ cord-313694-p2sgaypq 113 33 cells cell NNS cord-313694-p2sgaypq 113 34 ( ( -LRB- cord-313694-p2sgaypq 113 35 27 27 CD cord-313694-p2sgaypq 113 36 ) ) -RRB- cord-313694-p2sgaypq 113 37 . . . cord-313694-p2sgaypq 114 1 Plasma plasma NN cord-313694-p2sgaypq 114 2 membrane membrane NN cord-313694-p2sgaypq 114 3 carbohydrate carbohydrate NN cord-313694-p2sgaypq 114 4 , , , cord-313694-p2sgaypq 114 5 owing owe VBG cord-313694-p2sgaypq 114 6 to to IN cord-313694-p2sgaypq 114 7 intercarbohydrate intercarbohydrate NNP cord-313694-p2sgaypq 114 8 associations association NNS cord-313694-p2sgaypq 114 9 , , , cord-313694-p2sgaypq 114 10 might may MD cord-313694-p2sgaypq 114 11 also also RB cord-313694-p2sgaypq 114 12 influence influence VB cord-313694-p2sgaypq 114 13 the the DT cord-313694-p2sgaypq 114 14 lateral lateral JJ cord-313694-p2sgaypq 114 15 diffusion diffusion NN cord-313694-p2sgaypq 114 16 of of IN cord-313694-p2sgaypq 114 17 certain certain JJ cord-313694-p2sgaypq 114 18 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 114 19 . . . cord-313694-p2sgaypq 115 1 Inter Inter NNP cord-313694-p2sgaypq 115 2 - - JJ cord-313694-p2sgaypq 115 3 molecular molecular JJ cord-313694-p2sgaypq 115 4 association association NN cord-313694-p2sgaypq 115 5 at at IN cord-313694-p2sgaypq 115 6 the the DT cord-313694-p2sgaypq 115 7 cell cell NN cord-313694-p2sgaypq 115 8 surface surface NN cord-313694-p2sgaypq 115 9 has have VBZ cord-313694-p2sgaypq 115 10 been be VBN cord-313694-p2sgaypq 115 11 suggested suggest VBN cord-313694-p2sgaypq 115 12 to to TO cord-313694-p2sgaypq 115 13 be be VB cord-313694-p2sgaypq 115 14 so so RB cord-313694-p2sgaypq 115 15 extensive extensive JJ cord-313694-p2sgaypq 115 16 in in IN cord-313694-p2sgaypq 115 17 an an DT cord-313694-p2sgaypq 115 18 archeobacterial archeobacterial JJ cord-313694-p2sgaypq 115 19 system system NN cord-313694-p2sgaypq 115 20 that that WDT cord-313694-p2sgaypq 115 21 it -PRON- PRP cord-313694-p2sgaypq 115 22 can can MD cord-313694-p2sgaypq 115 23 influence influence VB cord-313694-p2sgaypq 115 24 the the DT cord-313694-p2sgaypq 115 25 shape shape NN cord-313694-p2sgaypq 115 26 of of IN cord-313694-p2sgaypq 115 27 the the DT cord-313694-p2sgaypq 115 28 included include VBN cord-313694-p2sgaypq 115 29 cell cell NN cord-313694-p2sgaypq 115 30 ( ( -LRB- cord-313694-p2sgaypq 115 31 11 11 CD cord-313694-p2sgaypq 115 32 ) ) -RRB- cord-313694-p2sgaypq 115 33 . . . cord-313694-p2sgaypq 116 1 An an DT cord-313694-p2sgaypq 116 2 extension extension NN cord-313694-p2sgaypq 116 3 of of IN cord-313694-p2sgaypq 116 4 intermolecular intermolecular NNP cord-313694-p2sgaypq 116 5 association association NNP cord-313694-p2sgaypq 116 6 to to TO cord-313694-p2sgaypq 116 7 contact contact VB cord-313694-p2sgaypq 116 8 between between IN cord-313694-p2sgaypq 116 9 two two CD cord-313694-p2sgaypq 116 10 cells cell NNS cord-313694-p2sgaypq 116 11 in in IN cord-313694-p2sgaypq 116 12 close close JJ cord-313694-p2sgaypq 116 13 mutual mutual JJ cord-313694-p2sgaypq 116 14 proximity proximity NN cord-313694-p2sgaypq 116 15 leads lead VBZ cord-313694-p2sgaypq 116 16 to to IN cord-313694-p2sgaypq 116 17 a a DT cord-313694-p2sgaypq 116 18 possible possible JJ cord-313694-p2sgaypq 116 19 mechanism mechanism NN cord-313694-p2sgaypq 116 20 for for IN cord-313694-p2sgaypq 116 21 cell cell NN cord-313694-p2sgaypq 116 22 adhesion adhesion NN cord-313694-p2sgaypq 116 23 . . . cord-313694-p2sgaypq 117 1 Interaction interaction NN cord-313694-p2sgaypq 117 2 of of IN cord-313694-p2sgaypq 117 3 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 117 4 might may MD cord-313694-p2sgaypq 117 5 be be VB cord-313694-p2sgaypq 117 6 due due JJ cord-313694-p2sgaypq 117 7 to to IN cord-313694-p2sgaypq 117 8 an an DT cord-313694-p2sgaypq 117 9 apposition apposition NN cord-313694-p2sgaypq 117 10 of of IN cord-313694-p2sgaypq 117 11 the the DT cord-313694-p2sgaypq 117 12 hydrophobic hydrophobic JJ cord-313694-p2sgaypq 117 13 faces face NNS cord-313694-p2sgaypq 117 14 of of IN cord-313694-p2sgaypq 117 15 two two CD cord-313694-p2sgaypq 117 16 monosaccharides monosaccharide NNS cord-313694-p2sgaypq 117 17 such such JJ cord-313694-p2sgaypq 117 18 as as IN cord-313694-p2sgaypq 117 19 mannose mannose NN cord-313694-p2sgaypq 117 20 ( ( -LRB- cord-313694-p2sgaypq 117 21 126 126 CD cord-313694-p2sgaypq 117 22 ) ) -RRB- cord-313694-p2sgaypq 117 23 . . . cord-313694-p2sgaypq 118 1 Implicit implicit JJ cord-313694-p2sgaypq 118 2 in in IN cord-313694-p2sgaypq 118 3 this this DT cord-313694-p2sgaypq 118 4 model model NN cord-313694-p2sgaypq 118 5 is be VBZ cord-313694-p2sgaypq 118 6 the the DT cord-313694-p2sgaypq 118 7 idea idea NN cord-313694-p2sgaypq 118 8 of of IN cord-313694-p2sgaypq 118 9 a a DT cord-313694-p2sgaypq 118 10 large large JJ cord-313694-p2sgaypq 118 11 number number NN cord-313694-p2sgaypq 118 12 of of IN cord-313694-p2sgaypq 118 13 weak weak JJ cord-313694-p2sgaypq 118 14 interactions interaction NNS cord-313694-p2sgaypq 118 15 equalling equal VBG cord-313694-p2sgaypq 118 16 in in IN cord-313694-p2sgaypq 118 17 strength strength NN cord-313694-p2sgaypq 118 18 a a DT cord-313694-p2sgaypq 118 19 smaller small JJR cord-313694-p2sgaypq 118 20 number number NN cord-313694-p2sgaypq 118 21 of of IN cord-313694-p2sgaypq 118 22 strong strong JJ cord-313694-p2sgaypq 118 23 interactions interaction NNS cord-313694-p2sgaypq 118 24 . . . cord-313694-p2sgaypq 119 1 This this DT cord-313694-p2sgaypq 119 2 mechanism mechanism NN cord-313694-p2sgaypq 119 3 is be VBZ cord-313694-p2sgaypq 119 4 feasible feasible JJ cord-313694-p2sgaypq 119 5 in in IN cord-313694-p2sgaypq 119 6 polymeric polymeric JJ cord-313694-p2sgaypq 119 7 systems system NNS cord-313694-p2sgaypq 119 8 with with IN cord-313694-p2sgaypq 119 9 repreating repreate VBG cord-313694-p2sgaypq 119 10 similar similar JJ cord-313694-p2sgaypq 119 11 subunits subunit NNS cord-313694-p2sgaypq 119 12 . . . cord-313694-p2sgaypq 120 1 Cell cell NN cord-313694-p2sgaypq 120 2 surface surface NN cord-313694-p2sgaypq 120 3 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 120 4 could could MD cord-313694-p2sgaypq 120 5 simulate simulate VB cord-313694-p2sgaypq 120 6 a a DT cord-313694-p2sgaypq 120 7 polymer polymer NN cord-313694-p2sgaypq 120 8 inasmuch inasmuch NN cord-313694-p2sgaypq 120 9 as as IN cord-313694-p2sgaypq 120 10 they -PRON- PRP cord-313694-p2sgaypq 120 11 are be VBP cord-313694-p2sgaypq 120 12 coanchored coanchore VBN cord-313694-p2sgaypq 120 13 in in IN cord-313694-p2sgaypq 120 14 the the DT cord-313694-p2sgaypq 120 15 same same JJ cord-313694-p2sgaypq 120 16 membrane membrane NN cord-313694-p2sgaypq 120 17 . . . cord-313694-p2sgaypq 121 1 The the DT cord-313694-p2sgaypq 121 2 interactions interaction NNS cord-313694-p2sgaypq 121 3 involved involve VBN cord-313694-p2sgaypq 121 4 in in IN cord-313694-p2sgaypq 121 5 these these DT cord-313694-p2sgaypq 121 6 phenomena phenomenon NNS cord-313694-p2sgaypq 121 7 may may MD cord-313694-p2sgaypq 121 8 be be VB cord-313694-p2sgaypq 121 9 relatively relatively RB cord-313694-p2sgaypq 121 10 nonspecific nonspecific JJ cord-313694-p2sgaypq 121 11 . . . cord-313694-p2sgaypq 122 1 The the DT cord-313694-p2sgaypq 122 2 notion notion NN cord-313694-p2sgaypq 122 3 of of IN cord-313694-p2sgaypq 122 4 a a DT cord-313694-p2sgaypq 122 5 ' ' `` cord-313694-p2sgaypq 122 6 non non JJ cord-313694-p2sgaypq 122 7 - - JJ cord-313694-p2sgaypq 122 8 specific specific JJ cord-313694-p2sgaypq 122 9 ' ' '' cord-313694-p2sgaypq 122 10 role role NN cord-313694-p2sgaypq 122 11 for for IN cord-313694-p2sgaypq 122 12 carbohydrate carbohydrate NN cord-313694-p2sgaypq 122 13 has have VBZ cord-313694-p2sgaypq 122 14 received receive VBN cord-313694-p2sgaypq 122 15 perhaps perhaps RB cord-313694-p2sgaypq 122 16 its -PRON- PRP$ cord-313694-p2sgaypq 122 17 strongest strong JJS cord-313694-p2sgaypq 122 18 support support NN cord-313694-p2sgaypq 122 19 from from IN cord-313694-p2sgaypq 122 20 studies study NNS cord-313694-p2sgaypq 122 21 on on IN cord-313694-p2sgaypq 122 22 cells cell NNS cord-313694-p2sgaypq 122 23 whose whose WP$ cord-313694-p2sgaypq 122 24 glycosylation glycosylation NN cord-313694-p2sgaypq 122 25 processes process NNS cord-313694-p2sgaypq 122 26 have have VBP cord-313694-p2sgaypq 122 27 been be VBN cord-313694-p2sgaypq 122 28 globally globally RB cord-313694-p2sgaypq 122 29 altered alter VBN cord-313694-p2sgaypq 122 30 by by IN cord-313694-p2sgaypq 122 31 mutation mutation NN cord-313694-p2sgaypq 122 32 or or CC cord-313694-p2sgaypq 122 33 drugs drug NNS cord-313694-p2sgaypq 122 34 . . . cord-313694-p2sgaypq 123 1 The the DT cord-313694-p2sgaypq 123 2 most most RBS cord-313694-p2sgaypq 123 3 dramatic dramatic JJ cord-313694-p2sgaypq 123 4 studies study NNS cord-313694-p2sgaypq 123 5 have have VBP cord-313694-p2sgaypq 123 6 involved involve VBN cord-313694-p2sgaypq 123 7 mutant mutant JJ cord-313694-p2sgaypq 123 8 cells cell NNS cord-313694-p2sgaypq 123 9 selected select VBN cord-313694-p2sgaypq 123 10 on on IN cord-313694-p2sgaypq 123 11 the the DT cord-313694-p2sgaypq 123 12 basis basis NN cord-313694-p2sgaypq 123 13 of of IN cord-313694-p2sgaypq 123 14 resistance resistance NN cord-313694-p2sgaypq 123 15 to to IN cord-313694-p2sgaypq 123 16 the the DT cord-313694-p2sgaypq 123 17 toxic toxic JJ cord-313694-p2sgaypq 123 18 effects effect NNS cord-313694-p2sgaypq 123 19 of of IN cord-313694-p2sgaypq 123 20 certain certain JJ cord-313694-p2sgaypq 123 21 lectins lectin NNS cord-313694-p2sgaypq 123 22 . . . cord-313694-p2sgaypq 124 1 Many many JJ cord-313694-p2sgaypq 124 2 mutations mutation NNS cord-313694-p2sgaypq 124 3 leading lead VBG cord-313694-p2sgaypq 124 4 to to IN cord-313694-p2sgaypq 124 5 loss loss NN cord-313694-p2sgaypq 124 6 of of IN cord-313694-p2sgaypq 124 7 lectin lectin NN cord-313694-p2sgaypq 124 8 recognition recognition NN cord-313694-p2sgaypq 124 9 have have VBP cord-313694-p2sgaypq 124 10 been be VBN cord-313694-p2sgaypq 124 11 identified identify VBN cord-313694-p2sgaypq 124 12 in in IN cord-313694-p2sgaypq 124 13 CHO CHO NNP cord-313694-p2sgaypq 124 14 and and CC cord-313694-p2sgaypq 124 15 other other JJ cord-313694-p2sgaypq 124 16 cells cell NNS cord-313694-p2sgaypq 124 17 ( ( -LRB- cord-313694-p2sgaypq 124 18 20 20 CD cord-313694-p2sgaypq 124 19 ) ) -RRB- cord-313694-p2sgaypq 124 20 . . . cord-313694-p2sgaypq 125 1 Some some DT cord-313694-p2sgaypq 125 2 have have VBP cord-313694-p2sgaypq 125 3 been be VBN cord-313694-p2sgaypq 125 4 characterized characterize VBN cord-313694-p2sgaypq 125 5 and and CC cord-313694-p2sgaypq 125 6 in in IN cord-313694-p2sgaypq 125 7 fact fact NN cord-313694-p2sgaypq 125 8 most most JJS cord-313694-p2sgaypq 125 9 steps step NNS cord-313694-p2sgaypq 125 10 in in IN cord-313694-p2sgaypq 125 11 the the DT cord-313694-p2sgaypq 125 12 pathway pathway NN cord-313694-p2sgaypq 125 13 to to IN cord-313694-p2sgaypq 125 14 complex complex JJ cord-313694-p2sgaypq 125 15 , , , cord-313694-p2sgaypq 125 16 N n NN cord-313694-p2sgaypq 125 17 - - HYPH cord-313694-p2sgaypq 125 18 linked link VBN cord-313694-p2sgaypq 125 19 glycan glycan NN cord-313694-p2sgaypq 125 20 formation formation NN cord-313694-p2sgaypq 125 21 are be VBP cord-313694-p2sgaypq 125 22 mutable mutable JJ cord-313694-p2sgaypq 125 23 . . . cord-313694-p2sgaypq 126 1 The the DT cord-313694-p2sgaypq 126 2 striking striking JJ cord-313694-p2sgaypq 126 3 finding finding NN cord-313694-p2sgaypq 126 4 is be VBZ cord-313694-p2sgaypq 126 5 that that IN cord-313694-p2sgaypq 126 6 mutant mutant JJ cord-313694-p2sgaypq 126 7 cells cell NNS cord-313694-p2sgaypq 126 8 are be VBP cord-313694-p2sgaypq 126 9 largely largely RB cord-313694-p2sgaypq 126 10 viable viable JJ cord-313694-p2sgaypq 126 11 in in IN cord-313694-p2sgaypq 126 12 culture culture NN cord-313694-p2sgaypq 126 13 . . . cord-313694-p2sgaypq 127 1 Most most RBS cord-313694-p2sgaypq 127 2 mutant mutant JJ cord-313694-p2sgaypq 127 3 CHO CHO NNP cord-313694-p2sgaypq 127 4 cells cell NNS cord-313694-p2sgaypq 127 5 remain remain VBP cord-313694-p2sgaypq 127 6 adherent adherent JJ cord-313694-p2sgaypq 127 7 under under IN cord-313694-p2sgaypq 127 8 appropriate appropriate JJ cord-313694-p2sgaypq 127 9 conditions condition NNS cord-313694-p2sgaypq 127 10 , , , cord-313694-p2sgaypq 127 11 proliferate proliferate VBP cord-313694-p2sgaypq 127 12 , , , cord-313694-p2sgaypq 127 13 and and CC cord-313694-p2sgaypq 127 14 are be VBP cord-313694-p2sgaypq 127 15 tumorigenic tumorigenic JJ cord-313694-p2sgaypq 127 16 . . . cord-313694-p2sgaypq 128 1 Mutants mutant NNS cord-313694-p2sgaypq 128 2 defective defective JJ cord-313694-p2sgaypq 128 3 in in IN cord-313694-p2sgaypq 128 4 early early JJ cord-313694-p2sgaypq 128 5 steps step NNS cord-313694-p2sgaypq 128 6 leading lead VBG cord-313694-p2sgaypq 128 7 to to IN cord-313694-p2sgaypq 128 8 the the DT cord-313694-p2sgaypq 128 9 formation formation NN cord-313694-p2sgaypq 128 10 of of IN cord-313694-p2sgaypq 128 11 high high JJ cord-313694-p2sgaypq 128 12 - - HYPH cord-313694-p2sgaypq 128 13 mannose mannose NN cord-313694-p2sgaypq 128 14 glycans glycan NNS cord-313694-p2sgaypq 128 15 are be VBP cord-313694-p2sgaypq 128 16 also also RB cord-313694-p2sgaypq 128 17 viable viable JJ cord-313694-p2sgaypq 128 18 ( ( -LRB- cord-313694-p2sgaypq 128 19 24 24 CD cord-313694-p2sgaypq 128 20 ) ) -RRB- cord-313694-p2sgaypq 128 21 . . . cord-313694-p2sgaypq 129 1 This this DT cord-313694-p2sgaypq 129 2 result result NN cord-313694-p2sgaypq 129 3 was be VBD cord-313694-p2sgaypq 129 4 not not RB cord-313694-p2sgaypq 129 5 , , , cord-313694-p2sgaypq 129 6 however however RB cord-313694-p2sgaypq 129 7 , , , cord-313694-p2sgaypq 129 8 found find VBN cord-313694-p2sgaypq 129 9 in in IN cord-313694-p2sgaypq 129 10 a a DT cord-313694-p2sgaypq 129 11 yeast yeast NN cord-313694-p2sgaypq 129 12 mutant mutant NN cord-313694-p2sgaypq 129 13 ( ( -LRB- cord-313694-p2sgaypq 129 14 40 40 CD cord-313694-p2sgaypq 129 15 ) ) -RRB- cord-313694-p2sgaypq 129 16 . . . cord-313694-p2sgaypq 130 1 Selected select VBN cord-313694-p2sgaypq 130 2 activities activity NNS cord-313694-p2sgaypq 130 3 of of IN cord-313694-p2sgaypq 130 4 cells cell NNS cord-313694-p2sgaypq 130 5 have have VBP cord-313694-p2sgaypq 130 6 also also RB cord-313694-p2sgaypq 130 7 been be VBN cord-313694-p2sgaypq 130 8 investigated investigate VBN cord-313694-p2sgaypq 130 9 in in IN cord-313694-p2sgaypq 130 10 some some DT cord-313694-p2sgaypq 130 11 mutant mutant JJ cord-313694-p2sgaypq 130 12 strains strain NNS cord-313694-p2sgaypq 130 13 . . . cord-313694-p2sgaypq 131 1 For for IN cord-313694-p2sgaypq 131 2 example example NN cord-313694-p2sgaypq 131 3 , , , cord-313694-p2sgaypq 131 4 the the DT cord-313694-p2sgaypq 131 5 half half JJ cord-313694-p2sgaypq 131 6 - - HYPH cord-313694-p2sgaypq 131 7 life life NN cord-313694-p2sgaypq 131 8 of of IN cord-313694-p2sgaypq 131 9 cell cell NN cord-313694-p2sgaypq 131 10 surface surface NN cord-313694-p2sgaypq 131 11 proteins protein NNS cord-313694-p2sgaypq 131 12 was be VBD cord-313694-p2sgaypq 131 13 found find VBN cord-313694-p2sgaypq 131 14 not not RB cord-313694-p2sgaypq 131 15 to to TO cord-313694-p2sgaypq 131 16 be be VB cord-313694-p2sgaypq 131 17 dramatically dramatically RB cord-313694-p2sgaypq 131 18 affected affect VBN cord-313694-p2sgaypq 131 19 ( ( -LRB- cord-313694-p2sgaypq 131 20 23 23 CD cord-313694-p2sgaypq 131 21 ) ) -RRB- cord-313694-p2sgaypq 131 22 . . . cord-313694-p2sgaypq 132 1 Similar similar JJ cord-313694-p2sgaypq 132 2 results result NNS cord-313694-p2sgaypq 132 3 were be VBD cord-313694-p2sgaypq 132 4 found find VBN cord-313694-p2sgaypq 132 5 following follow VBG cord-313694-p2sgaypq 132 6 treatment treatment NN cord-313694-p2sgaypq 132 7 of of IN cord-313694-p2sgaypq 132 8 cells cell NNS cord-313694-p2sgaypq 132 9 with with IN cord-313694-p2sgaypq 132 10 sialidase sialidase NN cord-313694-p2sgaypq 132 11 ( ( -LRB- cord-313694-p2sgaypq 132 12 107 107 CD cord-313694-p2sgaypq 132 13 ) ) -RRB- cord-313694-p2sgaypq 132 14 . . . cord-313694-p2sgaypq 133 1 A a DT cord-313694-p2sgaypq 133 2 considerable considerable JJ cord-313694-p2sgaypq 133 3 literature literature NN cord-313694-p2sgaypq 133 4 details detail VBZ cord-313694-p2sgaypq 133 5 the the DT cord-313694-p2sgaypq 133 6 consequences consequence NNS cord-313694-p2sgaypq 133 7 of of IN cord-313694-p2sgaypq 133 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 133 9 modification modification NN cord-313694-p2sgaypq 133 10 on on IN cord-313694-p2sgaypq 133 11 the the DT cord-313694-p2sgaypq 133 12 secretory secretory JJ cord-313694-p2sgaypq 133 13 process process NN cord-313694-p2sgaypq 133 14 . . . cord-313694-p2sgaypq 134 1 Though though IN cord-313694-p2sgaypq 134 2 several several JJ cord-313694-p2sgaypq 134 3 examples example NNS cord-313694-p2sgaypq 134 4 of of IN cord-313694-p2sgaypq 134 5 apparently apparently RB cord-313694-p2sgaypq 134 6 specific specific JJ cord-313694-p2sgaypq 134 7 effects effect NNS cord-313694-p2sgaypq 134 8 will will MD cord-313694-p2sgaypq 134 9 be be VB cord-313694-p2sgaypq 134 10 enumerated enumerate VBN cord-313694-p2sgaypq 134 11 in in IN cord-313694-p2sgaypq 134 12 a a DT cord-313694-p2sgaypq 134 13 later later JJ cord-313694-p2sgaypq 134 14 section section NN cord-313694-p2sgaypq 134 15 , , , cord-313694-p2sgaypq 134 16 the the DT cord-313694-p2sgaypq 134 17 number number NN cord-313694-p2sgaypq 134 18 of of IN cord-313694-p2sgaypq 134 19 cases case NNS cord-313694-p2sgaypq 134 20 where where WRB cord-313694-p2sgaypq 134 21 little little JJ cord-313694-p2sgaypq 134 22 or or CC cord-313694-p2sgaypq 134 23 no no DT cord-313694-p2sgaypq 134 24 effect effect NN cord-313694-p2sgaypq 134 25 is be VBZ cord-313694-p2sgaypq 134 26 found find VBN cord-313694-p2sgaypq 134 27 is be VBZ cord-313694-p2sgaypq 134 28 noteworthy noteworthy JJ cord-313694-p2sgaypq 134 29 ( ( -LRB- cord-313694-p2sgaypq 134 30 82 82 CD cord-313694-p2sgaypq 134 31 , , , cord-313694-p2sgaypq 134 32 83 83 CD cord-313694-p2sgaypq 134 33 , , , cord-313694-p2sgaypq 134 34 98 98 CD cord-313694-p2sgaypq 134 35 , , , cord-313694-p2sgaypq 134 36 161 161 CD cord-313694-p2sgaypq 134 37 ) ) -RRB- cord-313694-p2sgaypq 134 38 . . . cord-313694-p2sgaypq 135 1 In in IN cord-313694-p2sgaypq 135 2 some some DT cord-313694-p2sgaypq 135 3 cases case NNS cord-313694-p2sgaypq 135 4 detailed detail VBN cord-313694-p2sgaypq 135 5 kinetic kinetic JJ cord-313694-p2sgaypq 135 6 analysis analysis NN cord-313694-p2sgaypq 135 7 has have VBZ cord-313694-p2sgaypq 135 8 found find VBN cord-313694-p2sgaypq 135 9 only only RB cord-313694-p2sgaypq 135 10 small small JJ cord-313694-p2sgaypq 135 11 effects effect NNS cord-313694-p2sgaypq 135 12 on on IN cord-313694-p2sgaypq 135 13 secretory secretory JJ cord-313694-p2sgaypq 135 14 rates rate NNS cord-313694-p2sgaypq 135 15 ( ( -LRB- cord-313694-p2sgaypq 135 16 159 159 CD cord-313694-p2sgaypq 135 17 ) ) -RRB- cord-313694-p2sgaypq 135 18 . . . cord-313694-p2sgaypq 136 1 Similar similar JJ cord-313694-p2sgaypq 136 2 results result NNS cord-313694-p2sgaypq 136 3 have have VBP cord-313694-p2sgaypq 136 4 been be VBN cord-313694-p2sgaypq 136 5 found find VBN cord-313694-p2sgaypq 136 6 regarding regard VBG cord-313694-p2sgaypq 136 7 accxumulation accxumulation NN cord-313694-p2sgaypq 136 8 of of IN cord-313694-p2sgaypq 136 9 receptors receptor NNS cord-313694-p2sgaypq 136 10 in in IN cord-313694-p2sgaypq 136 11 the the DT cord-313694-p2sgaypq 136 12 plasma plasma NN cord-313694-p2sgaypq 136 13 membrane membrane NN cord-313694-p2sgaypq 136 14 and and CC cord-313694-p2sgaypq 136 15 in in IN cord-313694-p2sgaypq 136 16 their -PRON- PRP$ cord-313694-p2sgaypq 136 17 function function NN cord-313694-p2sgaypq 136 18 at at IN cord-313694-p2sgaypq 136 19 that that DT cord-313694-p2sgaypq 136 20 site site NN cord-313694-p2sgaypq 136 21 ( ( -LRB- cord-313694-p2sgaypq 136 22 88 88 CD cord-313694-p2sgaypq 136 23 , , , cord-313694-p2sgaypq 136 24 99 99 CD cord-313694-p2sgaypq 136 25 , , , cord-313694-p2sgaypq 136 26 90 90 CD cord-313694-p2sgaypq 136 27 , , , cord-313694-p2sgaypq 136 28 164 164 CD cord-313694-p2sgaypq 136 29 ) ) -RRB- cord-313694-p2sgaypq 136 30 . . . cord-313694-p2sgaypq 137 1 Genetic genetic JJ cord-313694-p2sgaypq 137 2 modification modification NN cord-313694-p2sgaypq 137 3 of of IN cord-313694-p2sgaypq 137 4 the the DT cord-313694-p2sgaypq 137 5 gene gene NN cord-313694-p2sgaypq 137 6 for for IN cord-313694-p2sgaypq 137 7 the the DT cord-313694-p2sgaypq 137 8 LDL LDL NNP cord-313694-p2sgaypq 137 9 receptor receptor NN cord-313694-p2sgaypq 137 10 has have VBZ cord-313694-p2sgaypq 137 11 deleted delete VBN cord-313694-p2sgaypq 137 12 a a DT cord-313694-p2sgaypq 137 13 sequence sequence NN cord-313694-p2sgaypq 137 14 required require VBN cord-313694-p2sgaypq 137 15 for for IN cord-313694-p2sgaypq 137 16 a a DT cord-313694-p2sgaypq 137 17 cluster cluster NN cord-313694-p2sgaypq 137 18 of of IN cord-313694-p2sgaypq 137 19 O o NN cord-313694-p2sgaypq 137 20 - - HYPH cord-313694-p2sgaypq 137 21 linked link VBN cord-313694-p2sgaypq 137 22 glycans glycan NNS cord-313694-p2sgaypq 137 23 and and CC cord-313694-p2sgaypq 137 24 even even RB cord-313694-p2sgaypq 137 25 for for IN cord-313694-p2sgaypq 137 26 this this DT cord-313694-p2sgaypq 137 27 poorlystudied poorlystudie VBN cord-313694-p2sgaypq 137 28 glycan glycan NN cord-313694-p2sgaypq 137 29 type type NN cord-313694-p2sgaypq 138 1 no no DT cord-313694-p2sgaypq 138 2 consequence consequence NN cord-313694-p2sgaypq 138 3 on on IN cord-313694-p2sgaypq 138 4 function function NN cord-313694-p2sgaypq 138 5 could could MD cord-313694-p2sgaypq 138 6 be be VB cord-313694-p2sgaypq 138 7 detected detect VBN cord-313694-p2sgaypq 138 8 ( ( -LRB- cord-313694-p2sgaypq 138 9 163 163 CD cord-313694-p2sgaypq 138 10 ) ) -RRB- cord-313694-p2sgaypq 138 11 . . . cord-313694-p2sgaypq 139 1 Mutants mutant NNS cord-313694-p2sgaypq 139 2 in in IN cord-313694-p2sgaypq 139 3 the the DT cord-313694-p2sgaypq 139 4 enzymatic enzymatic JJ cord-313694-p2sgaypq 139 5 pathway pathway NN cord-313694-p2sgaypq 139 6 of of IN cord-313694-p2sgaypq 139 7 O o NN cord-313694-p2sgaypq 139 8 - - HYPH cord-313694-p2sgaypq 139 9 glycosylation glycosylation NN cord-313694-p2sgaypq 139 10 still still RB cord-313694-p2sgaypq 139 11 place place VBP cord-313694-p2sgaypq 139 12 the the DT cord-313694-p2sgaypq 139 13 LDL LDL NNP cord-313694-p2sgaypq 139 14 receptor receptor NN cord-313694-p2sgaypq 139 15 , , , cord-313694-p2sgaypq 139 16 albeit albeit IN cord-313694-p2sgaypq 139 17 in in IN cord-313694-p2sgaypq 139 18 a a DT cord-313694-p2sgaypq 139 19 less less RBR cord-313694-p2sgaypq 139 20 stable stable JJ cord-313694-p2sgaypq 139 21 form form NN cord-313694-p2sgaypq 139 22 , , , cord-313694-p2sgaypq 139 23 on on IN cord-313694-p2sgaypq 139 24 the the DT cord-313694-p2sgaypq 139 25 cell cell NN cord-313694-p2sgaypq 139 26 surface surface NN cord-313694-p2sgaypq 139 27 ( ( -LRB- cord-313694-p2sgaypq 139 28 165 165 CD cord-313694-p2sgaypq 139 29 ) ) -RRB- cord-313694-p2sgaypq 139 30 . . . cord-313694-p2sgaypq 140 1 These these DT cord-313694-p2sgaypq 140 2 negative negative JJ cord-313694-p2sgaypq 140 3 results result NNS cord-313694-p2sgaypq 140 4 have have VBP cord-313694-p2sgaypq 140 5 suggested suggest VBN cord-313694-p2sgaypq 140 6 that that IN cord-313694-p2sgaypq 140 7 carbohydrate carbohydrate NN cord-313694-p2sgaypq 140 8 can can MD cord-313694-p2sgaypq 140 9 not not RB cord-313694-p2sgaypq 140 10 underlie underlie VB cord-313694-p2sgaypq 140 11 essential essential JJ cord-313694-p2sgaypq 140 12 housekeeping housekeeping NN cord-313694-p2sgaypq 140 13 functions function NNS cord-313694-p2sgaypq 140 14 in in IN cord-313694-p2sgaypq 140 15 cells cell NNS cord-313694-p2sgaypq 140 16 . . . cord-313694-p2sgaypq 141 1 This this DT cord-313694-p2sgaypq 141 2 implies imply VBZ cord-313694-p2sgaypq 141 3 a a DT cord-313694-p2sgaypq 141 4 non non JJ cord-313694-p2sgaypq 141 5 - - JJ cord-313694-p2sgaypq 141 6 specificity specificity NN cord-313694-p2sgaypq 141 7 of of IN cord-313694-p2sgaypq 141 8 function function NN cord-313694-p2sgaypq 141 9 in in IN cord-313694-p2sgaypq 141 10 the the DT cord-313694-p2sgaypq 141 11 sense sense NN cord-313694-p2sgaypq 141 12 that that IN cord-313694-p2sgaypq 141 13 obvious obvious JJ cord-313694-p2sgaypq 141 14 functions function NNS cord-313694-p2sgaypq 141 15 can can MD cord-313694-p2sgaypq 141 16 not not RB cord-313694-p2sgaypq 141 17 specifically specifically RB cord-313694-p2sgaypq 141 18 be be VB cord-313694-p2sgaypq 141 19 attributed attribute VBN cord-313694-p2sgaypq 141 20 to to IN cord-313694-p2sgaypq 141 21 the the DT cord-313694-p2sgaypq 141 22 carbohydrate carbohydrate NN cord-313694-p2sgaypq 141 23 when when WRB cord-313694-p2sgaypq 141 24 it -PRON- PRP cord-313694-p2sgaypq 141 25 is be VBZ cord-313694-p2sgaypq 141 26 present present JJ cord-313694-p2sgaypq 141 27 . . . cord-313694-p2sgaypq 142 1 This this DT cord-313694-p2sgaypq 142 2 represents represent VBZ cord-313694-p2sgaypq 142 3 a a DT cord-313694-p2sgaypq 142 4 shift shift NN cord-313694-p2sgaypq 142 5 in in IN cord-313694-p2sgaypq 142 6 meaning meaning NN cord-313694-p2sgaypq 142 7 from from IN cord-313694-p2sgaypq 142 8 the the DT cord-313694-p2sgaypq 142 9 above above JJ cord-313694-p2sgaypq 142 10 definition definition NN cord-313694-p2sgaypq 142 11 of of IN cord-313694-p2sgaypq 142 12 nonspecificity nonspecificity NN cord-313694-p2sgaypq 142 13 inasmuch inasmuch JJ cord-313694-p2sgaypq 142 14 as as IN cord-313694-p2sgaypq 142 15 specific specific JJ cord-313694-p2sgaypq 142 16 receptors receptor NNS cord-313694-p2sgaypq 142 17 may may MD cord-313694-p2sgaypq 142 18 be be VB cord-313694-p2sgaypq 142 19 involved involve VBN cord-313694-p2sgaypq 142 20 in in IN cord-313694-p2sgaypq 142 21 functions function NNS cord-313694-p2sgaypq 142 22 non non JJ cord-313694-p2sgaypq 142 23 - - JJ cord-313694-p2sgaypq 142 24 essential essential JJ cord-313694-p2sgaypq 142 25 in in IN cord-313694-p2sgaypq 142 26 the the DT cord-313694-p2sgaypq 142 27 tissue tissue NN cord-313694-p2sgaypq 142 28 culture culture NN cord-313694-p2sgaypq 142 29 environment environment NN cord-313694-p2sgaypq 142 30 . . . cord-313694-p2sgaypq 143 1 Thus thus RB cord-313694-p2sgaypq 143 2 it -PRON- PRP cord-313694-p2sgaypq 143 3 has have VBZ cord-313694-p2sgaypq 143 4 alternatively alternatively RB cord-313694-p2sgaypq 143 5 been be VBN cord-313694-p2sgaypq 143 6 suggested suggest VBN cord-313694-p2sgaypq 143 7 that that IN cord-313694-p2sgaypq 143 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 143 9 may may MD cord-313694-p2sgaypq 143 10 be be VB cord-313694-p2sgaypq 143 11 more more RBR cord-313694-p2sgaypq 143 12 important important JJ cord-313694-p2sgaypq 143 13 for for IN cord-313694-p2sgaypq 143 14 particular particular JJ cord-313694-p2sgaypq 143 15 differentiated differentiated JJ cord-313694-p2sgaypq 143 16 functions function NNS cord-313694-p2sgaypq 143 17 , , , cord-313694-p2sgaypq 143 18 which which WDT cord-313694-p2sgaypq 143 19 are be VBP cord-313694-p2sgaypq 143 20 not not RB cord-313694-p2sgaypq 143 21 expressed express VBN cord-313694-p2sgaypq 143 22 in in IN cord-313694-p2sgaypq 143 23 cell cell NN cord-313694-p2sgaypq 143 24 culture culture NN cord-313694-p2sgaypq 143 25 systems system NNS cord-313694-p2sgaypq 143 26 such such JJ cord-313694-p2sgaypq 143 27 as as IN cord-313694-p2sgaypq 143 28 the the DT cord-313694-p2sgaypq 143 29 CHO CHO NNP cord-313694-p2sgaypq 143 30 cell cell NN cord-313694-p2sgaypq 143 31 line line NN cord-313694-p2sgaypq 143 32 . . . cord-313694-p2sgaypq 144 1 There there EX cord-313694-p2sgaypq 144 2 are be VBP cord-313694-p2sgaypq 144 3 but but CC cord-313694-p2sgaypq 144 4 few few JJ cord-313694-p2sgaypq 144 5 investigations investigation NNS cord-313694-p2sgaypq 144 6 into into IN cord-313694-p2sgaypq 144 7 this this DT cord-313694-p2sgaypq 144 8 possibility possibility NN cord-313694-p2sgaypq 144 9 . . . cord-313694-p2sgaypq 145 1 For for IN cord-313694-p2sgaypq 145 2 example example NN cord-313694-p2sgaypq 145 3 , , , cord-313694-p2sgaypq 145 4 in in IN cord-313694-p2sgaypq 145 5 the the DT cord-313694-p2sgaypq 145 6 cellular cellular JJ cord-313694-p2sgaypq 145 7 slime slime NN cord-313694-p2sgaypq 145 8 mold mold NN cord-313694-p2sgaypq 145 9 D. D. NNP cord-313694-p2sgaypq 145 10 discoideum discoideum NNP cord-313694-p2sgaypq 145 11 , , , cord-313694-p2sgaypq 145 12 mutations mutation NNS cord-313694-p2sgaypq 145 13 have have VBP cord-313694-p2sgaypq 145 14 eliminated eliminate VBN cord-313694-p2sgaypq 145 15 two two CD cord-313694-p2sgaypq 145 16 developmentally developmentally RB cord-313694-p2sgaypq 145 17 regulated regulated JJ cord-313694-p2sgaypq 145 18 glycoantigens glycoantigen NNS cord-313694-p2sgaypq 145 19 ( ( -LRB- cord-313694-p2sgaypq 145 20 28 28 CD cord-313694-p2sgaypq 145 21 , , , cord-313694-p2sgaypq 145 22 29 29 CD cord-313694-p2sgaypq 145 23 ) ) -RRB- cord-313694-p2sgaypq 145 24 . . . cord-313694-p2sgaypq 146 1 Nevertheless nevertheless RB cord-313694-p2sgaypq 146 2 , , , cord-313694-p2sgaypq 146 3 the the DT cord-313694-p2sgaypq 146 4 cells cell NNS cord-313694-p2sgaypq 146 5 develop develop VBP cord-313694-p2sgaypq 146 6 reasonably reasonably RB cord-313694-p2sgaypq 146 7 normally normally RB cord-313694-p2sgaypq 146 8 to to TO cord-313694-p2sgaypq 146 9 produce produce VB cord-313694-p2sgaypq 146 10 fruiting fruit VBG cord-313694-p2sgaypq 146 11 bodies body NNS cord-313694-p2sgaypq 146 12 and and CC cord-313694-p2sgaypq 146 13 viable viable JJ cord-313694-p2sgaypq 146 14 spores spore NNS cord-313694-p2sgaypq 146 15 . . . cord-313694-p2sgaypq 147 1 The the DT cord-313694-p2sgaypq 147 2 result result NN cord-313694-p2sgaypq 147 3 may may MD cord-313694-p2sgaypq 147 4 imply imply VB cord-313694-p2sgaypq 147 5 that that IN cord-313694-p2sgaypq 147 6 carbohydrate carbohydrate NN cord-313694-p2sgaypq 147 7 is be VBZ cord-313694-p2sgaypq 147 8 either either CC cord-313694-p2sgaypq 147 9 nonspecific nonspecific JJ cord-313694-p2sgaypq 147 10 or or CC cord-313694-p2sgaypq 147 11 subserves subserve VBZ cord-313694-p2sgaypq 147 12 subtle subtle JJ cord-313694-p2sgaypq 147 13 modulatory modulatory JJ cord-313694-p2sgaypq 147 14 roles role NNS cord-313694-p2sgaypq 147 15 or or CC cord-313694-p2sgaypq 147 16 that that IN cord-313694-p2sgaypq 147 17 their -PRON- PRP$ cord-313694-p2sgaypq 147 18 roles role NNS cord-313694-p2sgaypq 147 19 are be VBP cord-313694-p2sgaypq 147 20 redundant redundant JJ cord-313694-p2sgaypq 147 21 with with IN cord-313694-p2sgaypq 147 22 alternate alternate JJ cord-313694-p2sgaypq 147 23 ( ( -LRB- cord-313694-p2sgaypq 147 24 or or CC cord-313694-p2sgaypq 147 25 back back NN cord-313694-p2sgaypq 147 26 - - HYPH cord-313694-p2sgaypq 147 27 up up NN cord-313694-p2sgaypq 147 28 ) ) -RRB- cord-313694-p2sgaypq 147 29 mechanisms mechanism NNS cord-313694-p2sgaypq 147 30 . . . cord-313694-p2sgaypq 148 1 Alternatively alternatively RB cord-313694-p2sgaypq 148 2 , , , cord-313694-p2sgaypq 148 3 the the DT cord-313694-p2sgaypq 148 4 value value NN cord-313694-p2sgaypq 148 5 of of IN cord-313694-p2sgaypq 148 6 these these DT cord-313694-p2sgaypq 148 7 carbohydrate carbohydrate NN cord-313694-p2sgaypq 148 8 structures structure NNS cord-313694-p2sgaypq 148 9 may may MD cord-313694-p2sgaypq 148 10 only only RB cord-313694-p2sgaypq 148 11 become become VB cord-313694-p2sgaypq 148 12 evident evident JJ cord-313694-p2sgaypq 148 13 under under IN cord-313694-p2sgaypq 148 14 the the DT cord-313694-p2sgaypq 148 15 competitive competitive JJ cord-313694-p2sgaypq 148 16 conditions condition NNS cord-313694-p2sgaypq 148 17 of of IN cord-313694-p2sgaypq 148 18 natural natural JJ cord-313694-p2sgaypq 148 19 survival survival NN cord-313694-p2sgaypq 148 20 outside outside IN cord-313694-p2sgaypq 148 21 of of IN cord-313694-p2sgaypq 148 22 the the DT cord-313694-p2sgaypq 148 23 laboratory laboratory NN cord-313694-p2sgaypq 148 24 . . . cord-313694-p2sgaypq 149 1 Although although IN cord-313694-p2sgaypq 149 2 the the DT cord-313694-p2sgaypq 149 3 above above JJ cord-313694-p2sgaypq 149 4 ideas idea NNS cord-313694-p2sgaypq 149 5 have have VBP cord-313694-p2sgaypq 149 6 been be VBN cord-313694-p2sgaypq 149 7 grouped group VBN cord-313694-p2sgaypq 149 8 together together RB cord-313694-p2sgaypq 149 9 under under IN cord-313694-p2sgaypq 149 10 ' ' `` cord-313694-p2sgaypq 149 11 non non JJ cord-313694-p2sgaypq 149 12 - - JJ cord-313694-p2sgaypq 149 13 specific specific JJ cord-313694-p2sgaypq 149 14 mechanisms mechanism NNS cord-313694-p2sgaypq 149 15 ' ' '' cord-313694-p2sgaypq 149 16 , , , cord-313694-p2sgaypq 149 17 this this DT cord-313694-p2sgaypq 149 18 is be VBZ cord-313694-p2sgaypq 149 19 not not RB cord-313694-p2sgaypq 149 20 meant mean VBN cord-313694-p2sgaypq 149 21 to to TO cord-313694-p2sgaypq 149 22 imply imply VB cord-313694-p2sgaypq 149 23 that that IN cord-313694-p2sgaypq 149 24 carbohydrate carbohydrate NN cord-313694-p2sgaypq 149 25 structure structure NN cord-313694-p2sgaypq 149 26 per per FW cord-313694-p2sgaypq 149 27 se se FW cord-313694-p2sgaypq 149 28 is be VBZ cord-313694-p2sgaypq 149 29 completely completely RB cord-313694-p2sgaypq 149 30 irrelevant irrelevant JJ cord-313694-p2sgaypq 149 31 . . . cord-313694-p2sgaypq 149 32 ' ' '' cord-313694-p2sgaypq 150 1 Non non JJ cord-313694-p2sgaypq 150 2 - - JJ cord-313694-p2sgaypq 150 3 specific specific JJ cord-313694-p2sgaypq 150 4 ' ' '' cord-313694-p2sgaypq 150 5 should should MD cord-313694-p2sgaypq 150 6 be be VB cord-313694-p2sgaypq 150 7 interpreted interpret VBN cord-313694-p2sgaypq 150 8 relative relative JJ cord-313694-p2sgaypq 150 9 to to IN cord-313694-p2sgaypq 150 10 the the DT cord-313694-p2sgaypq 150 11 types type NNS cord-313694-p2sgaypq 150 12 to to TO cord-313694-p2sgaypq 150 13 be be VB cord-313694-p2sgaypq 150 14 discussed discuss VBN cord-313694-p2sgaypq 150 15 below below RB cord-313694-p2sgaypq 150 16 , , , cord-313694-p2sgaypq 150 17 were be VBD cord-313694-p2sgaypq 150 18 specific specific JJ cord-313694-p2sgaypq 150 19 , , , cord-313694-p2sgaypq 150 20 saturable saturable JJ cord-313694-p2sgaypq 150 21 recognition recognition NN cord-313694-p2sgaypq 150 22 mechanisms mechanism NNS cord-313694-p2sgaypq 150 23 related relate VBN cord-313694-p2sgaypq 150 24 in in IN cord-313694-p2sgaypq 150 25 principle principle NN cord-313694-p2sgaypq 150 26 to to IN cord-313694-p2sgaypq 150 27 enzyme enzyme NN cord-313694-p2sgaypq 150 28 - - HYPH cord-313694-p2sgaypq 150 29 substrate substrate NN cord-313694-p2sgaypq 150 30 or or CC cord-313694-p2sgaypq 150 31 hormone hormone NN cord-313694-p2sgaypq 150 32 - - HYPH cord-313694-p2sgaypq 150 33 receptor receptor NN cord-313694-p2sgaypq 150 34 interactions interaction NNS cord-313694-p2sgaypq 150 35 are be VBP cord-313694-p2sgaypq 150 36 apperently apperently RB cord-313694-p2sgaypq 150 37 involved involved JJ cord-313694-p2sgaypq 150 38 . . . cord-313694-p2sgaypq 151 1 In in IN cord-313694-p2sgaypq 151 2 any any DT cord-313694-p2sgaypq 151 3 case case NN cord-313694-p2sgaypq 151 4 , , , cord-313694-p2sgaypq 151 5 the the DT cord-313694-p2sgaypq 151 6 non non JJ cord-313694-p2sgaypq 151 7 - - JJ cord-313694-p2sgaypq 151 8 specific specific JJ cord-313694-p2sgaypq 151 9 mechanisms mechanism NNS cord-313694-p2sgaypq 151 10 tend tend VBP cord-313694-p2sgaypq 151 11 to to TO cord-313694-p2sgaypq 151 12 rely rely VB cord-313694-p2sgaypq 151 13 on on IN cord-313694-p2sgaypq 151 14 the the DT cord-313694-p2sgaypq 151 15 bulk bulk JJ cord-313694-p2sgaypq 151 16 chemical chemical NN cord-313694-p2sgaypq 151 17 properties property NNS cord-313694-p2sgaypq 151 18 of of IN cord-313694-p2sgaypq 151 19 the the DT cord-313694-p2sgaypq 151 20 participating participate VBG cord-313694-p2sgaypq 151 21 oligo(poly)saccharides oligo(poly)saccharide NNS cord-313694-p2sgaypq 151 22 . . . cord-313694-p2sgaypq 152 1 This this DT cord-313694-p2sgaypq 152 2 phrase phrase NN cord-313694-p2sgaypq 152 3 implies imply VBZ cord-313694-p2sgaypq 152 4 interactions interaction NNS cord-313694-p2sgaypq 152 5 between between IN cord-313694-p2sgaypq 152 6 receptors receptor NNS cord-313694-p2sgaypq 152 7 and and CC cord-313694-p2sgaypq 152 8 ligands ligand NNS cord-313694-p2sgaypq 152 9 ( ( -LRB- cord-313694-p2sgaypq 152 10 usually usually RB cord-313694-p2sgaypq 152 11 the the DT cord-313694-p2sgaypq 152 12 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 152 13 ) ) -RRB- cord-313694-p2sgaypq 152 14 of of IN cord-313694-p2sgaypq 152 15 saturability saturability NN cord-313694-p2sgaypq 152 16 and and CC cord-313694-p2sgaypq 152 17 high high JJ cord-313694-p2sgaypq 152 18 selectivity selectivity NN cord-313694-p2sgaypq 152 19 and and CC cord-313694-p2sgaypq 152 20 avidity avidity NN cord-313694-p2sgaypq 152 21 . . . cord-313694-p2sgaypq 153 1 Selectivity selectivity NN cord-313694-p2sgaypq 153 2 can can MD cord-313694-p2sgaypq 153 3 be be VB cord-313694-p2sgaypq 153 4 achieved achieve VBN cord-313694-p2sgaypq 153 5 by by IN cord-313694-p2sgaypq 153 6 high high JJ cord-313694-p2sgaypq 153 7 affinity affinity NN cord-313694-p2sgaypq 153 8 monovalent monovalent NN cord-313694-p2sgaypq 153 9 interactions interaction NNS cord-313694-p2sgaypq 153 10 or or CC cord-313694-p2sgaypq 153 11 multiple multiple JJ cord-313694-p2sgaypq 153 12 weaker weak JJR cord-313694-p2sgaypq 153 13 interactions interaction NNS cord-313694-p2sgaypq 153 14 . . . cord-313694-p2sgaypq 154 1 Selective selective JJ cord-313694-p2sgaypq 154 2 interaction interaction NN cord-313694-p2sgaypq 154 3 is be VBZ cord-313694-p2sgaypq 154 4 often often RB cord-313694-p2sgaypq 154 5 equated equate VBN cord-313694-p2sgaypq 154 6 with with IN cord-313694-p2sgaypq 154 7 molecular molecular JJ cord-313694-p2sgaypq 154 8 or or CC cord-313694-p2sgaypq 154 9 , , , cord-313694-p2sgaypq 154 10 on on IN cord-313694-p2sgaypq 154 11 a a DT cord-313694-p2sgaypq 154 12 more more RBR cord-313694-p2sgaypq 154 13 complex complex JJ cord-313694-p2sgaypq 154 14 level level NN cord-313694-p2sgaypq 154 15 , , , cord-313694-p2sgaypq 154 16 cellular cellular JJ cord-313694-p2sgaypq 154 17 recognition recognition NN cord-313694-p2sgaypq 154 18 . . . cord-313694-p2sgaypq 155 1 The the DT cord-313694-p2sgaypq 155 2 phrase phrase NN cord-313694-p2sgaypq 155 3 also also RB cord-313694-p2sgaypq 155 4 implies imply VBZ cord-313694-p2sgaypq 155 5 that that IN cord-313694-p2sgaypq 155 6 a a DT cord-313694-p2sgaypq 155 7 specific specific JJ cord-313694-p2sgaypq 155 8 function function NN cord-313694-p2sgaypq 155 9 can can MD cord-313694-p2sgaypq 155 10 be be VB cord-313694-p2sgaypq 155 11 attributed attribute VBN cord-313694-p2sgaypq 155 12 to to IN cord-313694-p2sgaypq 155 13 the the DT cord-313694-p2sgaypq 155 14 carbohydrate carbohydrate NN cord-313694-p2sgaypq 155 15 structure structure NN cord-313694-p2sgaypq 155 16 . . . cord-313694-p2sgaypq 156 1 Perhaps perhaps RB cord-313694-p2sgaypq 156 2 the the DT cord-313694-p2sgaypq 156 3 strongest strong JJS cord-313694-p2sgaypq 156 4 indication indication NN cord-313694-p2sgaypq 156 5 for for IN cord-313694-p2sgaypq 156 6 specific specific JJ cord-313694-p2sgaypq 156 7 roles role NNS cord-313694-p2sgaypq 156 8 are be VBP cord-313694-p2sgaypq 156 9 the the DT cord-313694-p2sgaypq 156 10 variety variety NN cord-313694-p2sgaypq 156 11 of of IN cord-313694-p2sgaypq 156 12 structures structure NNS cord-313694-p2sgaypq 156 13 which which WDT cord-313694-p2sgaypq 156 14 have have VBP cord-313694-p2sgaypq 156 15 been be VBN cord-313694-p2sgaypq 156 16 detected detect VBN cord-313694-p2sgaypq 156 17 on on IN cord-313694-p2sgaypq 156 18 protein protein NN cord-313694-p2sgaypq 156 19 carbohydrate carbohydrate NN cord-313694-p2sgaypq 156 20 . . . cord-313694-p2sgaypq 157 1 The the DT cord-313694-p2sgaypq 157 2 following following JJ cord-313694-p2sgaypq 157 3 sections section NNS cord-313694-p2sgaypq 157 4 outline outline VBP cord-313694-p2sgaypq 157 5 how how WRB cord-313694-p2sgaypq 157 6 several several JJ cord-313694-p2sgaypq 157 7 characterized characterize VBN cord-313694-p2sgaypq 157 8 structures structure NNS cord-313694-p2sgaypq 157 9 are be VBP cord-313694-p2sgaypq 157 10 thought think VBN cord-313694-p2sgaypq 157 11 to to TO cord-313694-p2sgaypq 157 12 function function VB cord-313694-p2sgaypq 157 13 in in IN cord-313694-p2sgaypq 157 14 specialized specialized JJ cord-313694-p2sgaypq 157 15 processes process NNS cord-313694-p2sgaypq 157 16 . . . cord-313694-p2sgaypq 158 1 In in IN cord-313694-p2sgaypq 158 2 some some DT cord-313694-p2sgaypq 158 3 cases case NNS cord-313694-p2sgaypq 158 4 , , , cord-313694-p2sgaypq 158 5 a a DT cord-313694-p2sgaypq 158 6 receptor receptor NN cord-313694-p2sgaypq 158 7 protein protein NN cord-313694-p2sgaypq 158 8 capable capable JJ cord-313694-p2sgaypq 158 9 of of IN cord-313694-p2sgaypq 158 10 recognizing recognize VBG cord-313694-p2sgaypq 158 11 a a DT cord-313694-p2sgaypq 158 12 given give VBN cord-313694-p2sgaypq 158 13 structure structure NN cord-313694-p2sgaypq 158 14 is be VBZ cord-313694-p2sgaypq 158 15 known know VBN cord-313694-p2sgaypq 158 16 . . . cord-313694-p2sgaypq 159 1 In in IN cord-313694-p2sgaypq 159 2 1965 1965 CD cord-313694-p2sgaypq 159 3 Eylar Eylar NNP cord-313694-p2sgaypq 159 4 ( ( -LRB- cord-313694-p2sgaypq 159 5 80 80 CD cord-313694-p2sgaypq 159 6 ) ) -RRB- cord-313694-p2sgaypq 159 7 presented present VBD cord-313694-p2sgaypq 159 8 the the DT cord-313694-p2sgaypq 159 9 idea idea NN cord-313694-p2sgaypq 159 10 that that IN cord-313694-p2sgaypq 159 11 proteiL proteiL NNP cord-313694-p2sgaypq 159 12 ' ' POS cord-313694-p2sgaypq 159 13 glycans glycan NNS cord-313694-p2sgaypq 159 14 constitute constitute VBP cord-313694-p2sgaypq 159 15 a a DT cord-313694-p2sgaypq 159 16 ' ' `` cord-313694-p2sgaypq 159 17 chemical chemical NN cord-313694-p2sgaypq 159 18 passport passport NN cord-313694-p2sgaypq 159 19 ' ' '' cord-313694-p2sgaypq 159 20 signalling signal VBG cord-313694-p2sgaypq 159 21 export export NN cord-313694-p2sgaypq 159 22 of of IN cord-313694-p2sgaypq 159 23 a a DT cord-313694-p2sgaypq 159 24 protein protein NN cord-313694-p2sgaypq 159 25 to to IN cord-313694-p2sgaypq 159 26 the the DT cord-313694-p2sgaypq 159 27 cell cell NN cord-313694-p2sgaypq 159 28 surface surface NN cord-313694-p2sgaypq 159 29 or or CC cord-313694-p2sgaypq 159 30 for for IN cord-313694-p2sgaypq 159 31 secretion secretion NN cord-313694-p2sgaypq 159 32 . . . cord-313694-p2sgaypq 160 1 Though though IN cord-313694-p2sgaypq 160 2 this this DT cord-313694-p2sgaypq 160 3 idea idea NN cord-313694-p2sgaypq 160 4 has have VBZ cord-313694-p2sgaypq 160 5 since since IN cord-313694-p2sgaypq 160 6 been be VBN cord-313694-p2sgaypq 160 7 supplanted supplant VBN cord-313694-p2sgaypq 160 8 by by IN cord-313694-p2sgaypq 160 9 the the DT cord-313694-p2sgaypq 160 10 ' ' `` cord-313694-p2sgaypq 160 11 signal signal NN cord-313694-p2sgaypq 160 12 hypothesis hypothesis NN cord-313694-p2sgaypq 160 13 ' ' '' cord-313694-p2sgaypq 160 14 of of IN cord-313694-p2sgaypq 160 15 Blobel Blobel NNP cord-313694-p2sgaypq 160 16 and and CC cord-313694-p2sgaypq 160 17 Sabbatini Sabbatini NNP cord-313694-p2sgaypq 160 18 ( ( -LRB- cord-313694-p2sgaypq 160 19 150 150 CD cord-313694-p2sgaypq 160 20 ) ) -RRB- cord-313694-p2sgaypq 160 21 , , , cord-313694-p2sgaypq 160 22 it -PRON- PRP cord-313694-p2sgaypq 160 23 has have VBZ cord-313694-p2sgaypq 160 24 served serve VBN cord-313694-p2sgaypq 160 25 as as IN cord-313694-p2sgaypq 160 26 a a DT cord-313694-p2sgaypq 160 27 precursor precursor NN cord-313694-p2sgaypq 160 28 to to IN cord-313694-p2sgaypq 160 29 more more RBR cord-313694-p2sgaypq 160 30 refined refined JJ cord-313694-p2sgaypq 160 31 ideas idea NNS cord-313694-p2sgaypq 160 32 of of IN cord-313694-p2sgaypq 160 33 chemical chemical NN cord-313694-p2sgaypq 160 34 signals signal NNS cord-313694-p2sgaypq 160 35 leading lead VBG cord-313694-p2sgaypq 160 36 to to IN cord-313694-p2sgaypq 160 37 the the DT cord-313694-p2sgaypq 160 38 accumulation accumulation NN cord-313694-p2sgaypq 160 39 of of IN cord-313694-p2sgaypq 160 40 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 160 41 in in IN cord-313694-p2sgaypq 160 42 specific specific JJ cord-313694-p2sgaypq 160 43 compartments compartment NNS cord-313694-p2sgaypq 160 44 ( ( -LRB- cord-313694-p2sgaypq 160 45 81 81 CD cord-313694-p2sgaypq 160 46 ) ) -RRB- cord-313694-p2sgaypq 160 47 . . . cord-313694-p2sgaypq 161 1 For for IN cord-313694-p2sgaypq 161 2 example example NN cord-313694-p2sgaypq 161 3 , , , cord-313694-p2sgaypq 161 4 a a DT cord-313694-p2sgaypq 161 5 mannose-6-phosphate mannose-6-phosphate NNP cord-313694-p2sgaypq 161 6 moiety moiety NN cord-313694-p2sgaypq 161 7 has have VBZ cord-313694-p2sgaypq 161 8 been be VBN cord-313694-p2sgaypq 161 9 suggested suggest VBN cord-313694-p2sgaypq 161 10 to to TO cord-313694-p2sgaypq 161 11 be be VB cord-313694-p2sgaypq 161 12 responsible responsible JJ cord-313694-p2sgaypq 161 13 for for IN cord-313694-p2sgaypq 161 14 associating associate VBG cord-313694-p2sgaypq 161 15 proteins protein NNS cord-313694-p2sgaypq 161 16 with with IN cord-313694-p2sgaypq 161 17 receptors receptor NNS cord-313694-p2sgaypq 161 18 which which WDT cord-313694-p2sgaypq 161 19 in in IN cord-313694-p2sgaypq 161 20 turn turn NN cord-313694-p2sgaypq 161 21 lead lead VBP cord-313694-p2sgaypq 161 22 to to IN cord-313694-p2sgaypq 161 23 protein protein NN cord-313694-p2sgaypq 161 24 accumulation accumulation NN cord-313694-p2sgaypq 161 25 in in IN cord-313694-p2sgaypq 161 26 lysosomes lysosome NNS cord-313694-p2sgaypq 161 27 ( ( -LRB- cord-313694-p2sgaypq 161 28 134 134 CD cord-313694-p2sgaypq 161 29 ) ) -RRB- cord-313694-p2sgaypq 161 30 . . . cord-313694-p2sgaypq 162 1 The the DT cord-313694-p2sgaypq 162 2 key key NN cord-313694-p2sgaypq 162 3 to to IN cord-313694-p2sgaypq 162 4 this this DT cord-313694-p2sgaypq 162 5 understanding understanding NN cord-313694-p2sgaypq 162 6 was be VBD cord-313694-p2sgaypq 162 7 the the DT cord-313694-p2sgaypq 162 8 finding finding NN cord-313694-p2sgaypq 162 9 of of IN cord-313694-p2sgaypq 162 10 mutant mutant JJ cord-313694-p2sgaypq 162 11 cells cell NNS cord-313694-p2sgaypq 162 12 which which WDT cord-313694-p2sgaypq 162 13 appeared appear VBD cord-313694-p2sgaypq 162 14 to to TO cord-313694-p2sgaypq 162 15 secrete secrete VB cord-313694-p2sgaypq 162 16 constitutively constitutively RB cord-313694-p2sgaypq 162 17 certain certain JJ cord-313694-p2sgaypq 162 18 lysosomal lysosomal JJ cord-313694-p2sgaypq 162 19 enzymes enzyme NNS cord-313694-p2sgaypq 162 20 that that WDT cord-313694-p2sgaypq 162 21 were be VBD cord-313694-p2sgaypq 162 22 distinct distinct JJ cord-313694-p2sgaypq 162 23 in in IN cord-313694-p2sgaypq 162 24 their -PRON- PRP$ cord-313694-p2sgaypq 162 25 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 162 26 structures structure NNS cord-313694-p2sgaypq 162 27 : : : cord-313694-p2sgaypq 162 28 namely namely RB cord-313694-p2sgaypq 162 29 that that IN cord-313694-p2sgaypq 162 30 normal normal JJ cord-313694-p2sgaypq 162 31 enzymes enzyme NNS cord-313694-p2sgaypq 162 32 possessed possess VBD cord-313694-p2sgaypq 162 33 multiple multiple JJ cord-313694-p2sgaypq 162 34 phosphate phosphate NN cord-313694-p2sgaypq 162 35 residues residue NNS cord-313694-p2sgaypq 162 36 6 6 CD cord-313694-p2sgaypq 162 37 - - HYPH cord-313694-p2sgaypq 162 38 1inked 1inked CD cord-313694-p2sgaypq 162 39 to to IN cord-313694-p2sgaypq 162 40 non non JJ cord-313694-p2sgaypq 162 41 - - JJ cord-313694-p2sgaypq 162 42 peripheral peripheral JJ cord-313694-p2sgaypq 162 43 Mans Mans NNP cord-313694-p2sgaypq 162 44 in in IN cord-313694-p2sgaypq 162 45 high high JJ cord-313694-p2sgaypq 162 46 - - HYPH cord-313694-p2sgaypq 162 47 mannose mannose NN cord-313694-p2sgaypq 162 48 structures structure NNS cord-313694-p2sgaypq 162 49 , , , cord-313694-p2sgaypq 162 50 and and CC cord-313694-p2sgaypq 162 51 that that IN cord-313694-p2sgaypq 162 52 mutant mutant JJ cord-313694-p2sgaypq 162 53 enzymes enzyme NNS cord-313694-p2sgaypq 162 54 lacked lack VBD cord-313694-p2sgaypq 162 55 these these DT cord-313694-p2sgaypq 162 56 phosphate phosphate NN cord-313694-p2sgaypq 162 57 moieties moiety NNS cord-313694-p2sgaypq 162 58 . . . cord-313694-p2sgaypq 163 1 This this DT cord-313694-p2sgaypq 163 2 suggested suggest VBD cord-313694-p2sgaypq 163 3 that that IN cord-313694-p2sgaypq 163 4 there there EX cord-313694-p2sgaypq 163 5 was be VBD cord-313694-p2sgaypq 163 6 a a DT cord-313694-p2sgaypq 163 7 Man-6-PO man-6-po NN cord-313694-p2sgaypq 163 8 4 4 CD cord-313694-p2sgaypq 163 9 receptor receptor NN cord-313694-p2sgaypq 163 10 in in IN cord-313694-p2sgaypq 163 11 membranes membrane NNS cord-313694-p2sgaypq 163 12 of of IN cord-313694-p2sgaypq 163 13 the the DT cord-313694-p2sgaypq 163 14 Golgi Golgi NNP cord-313694-p2sgaypq 163 15 , , , cord-313694-p2sgaypq 163 16 and and CC cord-313694-p2sgaypq 163 17 plasma plasma NN cord-313694-p2sgaypq 163 18 membrane membrane NN cord-313694-p2sgaypq 163 19 ( ( -LRB- cord-313694-p2sgaypq 163 20 since since IN cord-313694-p2sgaypq 163 21 lysosomal lysosomal JJ cord-313694-p2sgaypq 163 22 enzymes enzyme NNS cord-313694-p2sgaypq 163 23 can can MD cord-313694-p2sgaypq 163 24 also also RB cord-313694-p2sgaypq 163 25 be be VB cord-313694-p2sgaypq 163 26 absorbed absorb VBN cord-313694-p2sgaypq 163 27 from from IN cord-313694-p2sgaypq 163 28 the the DT cord-313694-p2sgaypq 163 29 medium medium NN cord-313694-p2sgaypq 163 30 and and CC cord-313694-p2sgaypq 163 31 translocated translocate VBD cord-313694-p2sgaypq 163 32 to to IN cord-313694-p2sgaypq 163 33 lysosomes lysosome NNS cord-313694-p2sgaypq 163 34 ) ) -RRB- cord-313694-p2sgaypq 163 35 , , , cord-313694-p2sgaypq 163 36 which which WDT cord-313694-p2sgaypq 163 37 was be VBD cord-313694-p2sgaypq 163 38 responsible responsible JJ cord-313694-p2sgaypq 163 39 for for IN cord-313694-p2sgaypq 163 40 binding bind VBG cord-313694-p2sgaypq 163 41 the the DT cord-313694-p2sgaypq 163 42 Man-6-PO4 Man-6-PO4 NNP cord-313694-p2sgaypq 163 43 recognition recognition NN cord-313694-p2sgaypq 163 44 marker marker NN cord-313694-p2sgaypq 163 45 on on IN cord-313694-p2sgaypq 163 46 certain certain JJ cord-313694-p2sgaypq 163 47 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 163 48 . . . cord-313694-p2sgaypq 164 1 Two two CD cord-313694-p2sgaypq 164 2 such such JJ cord-313694-p2sgaypq 164 3 receptors receptor NNS cord-313694-p2sgaypq 164 4 , , , cord-313694-p2sgaypq 164 5 one one CD cord-313694-p2sgaypq 164 6 of of IN cord-313694-p2sgaypq 164 7 215kD 215kd CD cord-313694-p2sgaypq 164 8 and and CC cord-313694-p2sgaypq 164 9 the the DT cord-313694-p2sgaypq 164 10 other other JJ cord-313694-p2sgaypq 164 11 of of IN cord-313694-p2sgaypq 164 12 46kD 46kd CD cord-313694-p2sgaypq 164 13 , , , cord-313694-p2sgaypq 164 14 have have VBP cord-313694-p2sgaypq 164 15 been be VBN cord-313694-p2sgaypq 164 16 discovered discover VBN cord-313694-p2sgaypq 164 17 ( ( -LRB- cord-313694-p2sgaypq 164 18 157 157 CD cord-313694-p2sgaypq 164 19 , , , cord-313694-p2sgaypq 164 20 158 158 CD cord-313694-p2sgaypq 164 21 ) ) -RRB- cord-313694-p2sgaypq 164 22 . . . cord-313694-p2sgaypq 165 1 These these DT cord-313694-p2sgaypq 165 2 are be VBP cord-313694-p2sgaypq 165 3 located locate VBN cord-313694-p2sgaypq 165 4 in in IN cord-313694-p2sgaypq 165 5 the the DT cord-313694-p2sgaypq 165 6 Golgi Golgi NNP cord-313694-p2sgaypq 165 7 and/or and/or CC cord-313694-p2sgaypq 165 8 on on IN cord-313694-p2sgaypq 165 9 the the DT cord-313694-p2sgaypq 165 10 cell cell NN cord-313694-p2sgaypq 165 11 surface surface NN cord-313694-p2sgaypq 165 12 in in IN cord-313694-p2sgaypq 165 13 concordance concordance NN cord-313694-p2sgaypq 165 14 with with IN cord-313694-p2sgaypq 165 15 their -PRON- PRP$ cord-313694-p2sgaypq 165 16 proposed propose VBN cord-313694-p2sgaypq 165 17 functions function NNS cord-313694-p2sgaypq 165 18 . . . cord-313694-p2sgaypq 166 1 From from IN cord-313694-p2sgaypq 166 2 studies study NNS cord-313694-p2sgaypq 166 3 on on IN cord-313694-p2sgaypq 166 4 receptor receptor NN cord-313694-p2sgaypq 166 5 movement movement NN cord-313694-p2sgaypq 166 6 and and CC cord-313694-p2sgaypq 166 7 the the DT cord-313694-p2sgaypq 166 8 effects effect NNS cord-313694-p2sgaypq 166 9 of of IN cord-313694-p2sgaypq 166 10 inhibitors inhibitor NNS cord-313694-p2sgaypq 166 11 there there EX cord-313694-p2sgaypq 166 12 is be VBZ cord-313694-p2sgaypq 166 13 fairly fairly RB cord-313694-p2sgaypq 166 14 good good JJ cord-313694-p2sgaypq 166 15 evidence evidence NN cord-313694-p2sgaypq 166 16 that that IN cord-313694-p2sgaypq 166 17 the the DT cord-313694-p2sgaypq 166 18 Man-6-PO Man-6-PO NNP cord-313694-p2sgaypq 166 19 4 4 CD cord-313694-p2sgaypq 166 20 moiety moiety NN cord-313694-p2sgaypq 166 21 , , , cord-313694-p2sgaypq 166 22 together together RB cord-313694-p2sgaypq 166 23 with with IN cord-313694-p2sgaypq 166 24 one one CD cord-313694-p2sgaypq 166 25 or or CC cord-313694-p2sgaypq 166 26 both both DT cord-313694-p2sgaypq 166 27 of of IN cord-313694-p2sgaypq 166 28 these these DT cord-313694-p2sgaypq 166 29 receptors receptor NNS cord-313694-p2sgaypq 166 30 , , , cord-313694-p2sgaypq 166 31 plays play VBZ cord-313694-p2sgaypq 166 32 a a DT cord-313694-p2sgaypq 166 33 recognition recognition NN cord-313694-p2sgaypq 166 34 role role NN cord-313694-p2sgaypq 166 35 in in IN cord-313694-p2sgaypq 166 36 the the DT cord-313694-p2sgaypq 166 37 intracellular intracellular JJ cord-313694-p2sgaypq 166 38 routing routing NN cord-313694-p2sgaypq 166 39 . . . cord-313694-p2sgaypq 167 1 However however RB cord-313694-p2sgaypq 167 2 , , , cord-313694-p2sgaypq 167 3 not not RB cord-313694-p2sgaypq 167 4 all all DT cord-313694-p2sgaypq 167 5 lysosomal lysosomal JJ cord-313694-p2sgaypq 167 6 enzymes enzyme NNS cord-313694-p2sgaypq 167 7 seem seem VBP cord-313694-p2sgaypq 167 8 to to TO cord-313694-p2sgaypq 167 9 be be VB cord-313694-p2sgaypq 167 10 involved involve VBN cord-313694-p2sgaypq 167 11 because because IN cord-313694-p2sgaypq 167 12 some some DT cord-313694-p2sgaypq 167 13 copies copy NNS cord-313694-p2sgaypq 167 14 of of IN cord-313694-p2sgaypq 167 15 the the DT cord-313694-p2sgaypq 167 16 altered altered JJ cord-313694-p2sgaypq 167 17 enzymes enzyme NNS cord-313694-p2sgaypq 167 18 still still RB cord-313694-p2sgaypq 167 19 accumulate accumulate VBP cord-313694-p2sgaypq 167 20 in in IN cord-313694-p2sgaypq 167 21 mutant mutant JJ cord-313694-p2sgaypq 167 22 cells cell NNS cord-313694-p2sgaypq 167 23 ( ( -LRB- cord-313694-p2sgaypq 167 24 157 157 CD cord-313694-p2sgaypq 167 25 ) ) -RRB- cord-313694-p2sgaypq 167 26 , , , cord-313694-p2sgaypq 167 27 and and CC cord-313694-p2sgaypq 167 28 some some DT cord-313694-p2sgaypq 167 29 lysosomal lysosomal JJ cord-313694-p2sgaypq 167 30 enzymes enzyme NNS cord-313694-p2sgaypq 167 31 are be VBP cord-313694-p2sgaypq 167 32 not not RB cord-313694-p2sgaypq 167 33 affected affect VBN cord-313694-p2sgaypq 167 34 . . . cord-313694-p2sgaypq 168 1 It -PRON- PRP cord-313694-p2sgaypq 168 2 has have VBZ cord-313694-p2sgaypq 168 3 been be VBN cord-313694-p2sgaypq 168 4 suggested suggest VBN cord-313694-p2sgaypq 168 5 that that IN cord-313694-p2sgaypq 168 6 there there EX cord-313694-p2sgaypq 168 7 is be VBZ cord-313694-p2sgaypq 168 8 lysosomal lysosomal JJ cord-313694-p2sgaypq 168 9 heterogeneity heterogeneity NN cord-313694-p2sgaypq 168 10 with with IN cord-313694-p2sgaypq 168 11 only only RB cord-313694-p2sgaypq 168 12 one one CD cord-313694-p2sgaypq 168 13 class class NN cord-313694-p2sgaypq 168 14 of of IN cord-313694-p2sgaypq 168 15 lysosome lysosome NN cord-313694-p2sgaypq 168 16 employing employ VBG cord-313694-p2sgaypq 168 17 this this DT cord-313694-p2sgaypq 168 18 recognition recognition NN cord-313694-p2sgaypq 168 19 marker marker NN cord-313694-p2sgaypq 168 20 . . . cord-313694-p2sgaypq 169 1 It -PRON- PRP cord-313694-p2sgaypq 169 2 is be VBZ cord-313694-p2sgaypq 169 3 nevertheless nevertheless RB cord-313694-p2sgaypq 169 4 apparent apparent JJ cord-313694-p2sgaypq 169 5 that that IN cord-313694-p2sgaypq 169 6 for for IN cord-313694-p2sgaypq 169 7 some some DT cord-313694-p2sgaypq 169 8 lysosomal lysosomal JJ cord-313694-p2sgaypq 169 9 enzymes enzyme NNS cord-313694-p2sgaypq 169 10 in in IN cord-313694-p2sgaypq 169 11 some some DT cord-313694-p2sgaypq 169 12 cell cell NN cord-313694-p2sgaypq 169 13 types type NNS cord-313694-p2sgaypq 169 14 the the DT cord-313694-p2sgaypq 169 15 Man-6-PO4 Man-6-PO4 NNP cord-313694-p2sgaypq 169 16 receptor receptor NN cord-313694-p2sgaypq 169 17 does do VBZ cord-313694-p2sgaypq 169 18 not not RB cord-313694-p2sgaypq 169 19 function function VB cord-313694-p2sgaypq 169 20 alone alone RB cord-313694-p2sgaypq 169 21 , , , cord-313694-p2sgaypq 169 22 even even RB cord-313694-p2sgaypq 169 23 as as IN cord-313694-p2sgaypq 169 24 an an DT cord-313694-p2sgaypq 169 25 intermediate intermediate JJ cord-313694-p2sgaypq 169 26 signal signal NN cord-313694-p2sgaypq 169 27 , , , cord-313694-p2sgaypq 169 28 for for IN cord-313694-p2sgaypq 169 29 lysosomal lysosomal JJ cord-313694-p2sgaypq 169 30 routing routing NN cord-313694-p2sgaypq 169 31 . . . cord-313694-p2sgaypq 170 1 There there EX cord-313694-p2sgaypq 170 2 must must MD cord-313694-p2sgaypq 170 3 be be VB cord-313694-p2sgaypq 170 4 other other JJ cord-313694-p2sgaypq 170 5 recognition recognition NN cord-313694-p2sgaypq 170 6 signals signal NNS cord-313694-p2sgaypq 170 7 on on IN cord-313694-p2sgaypq 170 8 the the DT cord-313694-p2sgaypq 170 9 enzyme enzyme NN cord-313694-p2sgaypq 170 10 polypeptide polypeptide NN cord-313694-p2sgaypq 170 11 which which WDT cord-313694-p2sgaypq 170 12 lead lead VBP cord-313694-p2sgaypq 170 13 to to IN cord-313694-p2sgaypq 170 14 its -PRON- PRP$ cord-313694-p2sgaypq 170 15 potential potential JJ cord-313694-p2sgaypq 170 16 lysosomal lysosomal JJ cord-313694-p2sgaypq 170 17 accumulation accumulation NN cord-313694-p2sgaypq 170 18 . . . cord-313694-p2sgaypq 171 1 It -PRON- PRP cord-313694-p2sgaypq 171 2 is be VBZ cord-313694-p2sgaypq 171 3 interesting interesting JJ cord-313694-p2sgaypq 171 4 to to TO cord-313694-p2sgaypq 171 5 note note VB cord-313694-p2sgaypq 171 6 that that IN cord-313694-p2sgaypq 171 7 the the DT cord-313694-p2sgaypq 171 8 distinctive distinctive JJ cord-313694-p2sgaypq 171 9 carbohydrate carbohydrate NN cord-313694-p2sgaypq 171 10 structure structure NN cord-313694-p2sgaypq 171 11 plays play VBZ cord-313694-p2sgaypq 171 12 a a DT cord-313694-p2sgaypq 171 13 compartmentalization compartmentalization NN cord-313694-p2sgaypq 171 14 role role NN cord-313694-p2sgaypq 171 15 separate separate JJ cord-313694-p2sgaypq 171 16 from from IN cord-313694-p2sgaypq 171 17 the the DT cord-313694-p2sgaypq 171 18 enzyme enzyme NN cord-313694-p2sgaypq 171 19 's 's POS cord-313694-p2sgaypq 171 20 function function NN cord-313694-p2sgaypq 171 21 in in IN cord-313694-p2sgaypq 171 22 catalytic catalytic JJ cord-313694-p2sgaypq 171 23 degradation degradation NN cord-313694-p2sgaypq 171 24 . . . cord-313694-p2sgaypq 172 1 Furthermore furthermore RB cord-313694-p2sgaypq 172 2 , , , cord-313694-p2sgaypq 172 3 carbohydrate carbohydrate NN cord-313694-p2sgaypq 172 4 is be VBZ cord-313694-p2sgaypq 172 5 employed employ VBN cord-313694-p2sgaypq 172 6 to to TO cord-313694-p2sgaypq 172 7 perform perform VB cord-313694-p2sgaypq 172 8 a a DT cord-313694-p2sgaypq 172 9 common common JJ cord-313694-p2sgaypq 172 10 role role NN cord-313694-p2sgaypq 172 11 shared share VBN cord-313694-p2sgaypq 172 12 by by IN cord-313694-p2sgaypq 172 13 multiple multiple JJ cord-313694-p2sgaypq 172 14 proteins protein NNS cord-313694-p2sgaypq 172 15 . . . cord-313694-p2sgaypq 173 1 A a DT cord-313694-p2sgaypq 173 2 posttranslational posttranslational JJ cord-313694-p2sgaypq 173 3 modification modification NN cord-313694-p2sgaypq 173 4 such such JJ cord-313694-p2sgaypq 173 5 as as IN cord-313694-p2sgaypq 173 6 glycosylation glycosylation NN cord-313694-p2sgaypq 173 7 is be VBZ cord-313694-p2sgaypq 173 8 well well RB cord-313694-p2sgaypq 173 9 - - HYPH cord-313694-p2sgaypq 173 10 suited suit VBN cord-313694-p2sgaypq 173 11 to to IN cord-313694-p2sgaypq 173 12 the the DT cord-313694-p2sgaypq 173 13 demands demand NNS cord-313694-p2sgaypq 173 14 of of IN cord-313694-p2sgaypq 173 15 a a DT cord-313694-p2sgaypq 173 16 mechanism mechanism NN cord-313694-p2sgaypq 173 17 for for IN cord-313694-p2sgaypq 173 18 compartmentalization compartmentalization NN cord-313694-p2sgaypq 173 19 . . . cord-313694-p2sgaypq 174 1 The the DT cord-313694-p2sgaypq 174 2 RER RER NNP cord-313694-p2sgaypq 174 3 , , , cord-313694-p2sgaypq 174 4 Golgi Golgi NNP cord-313694-p2sgaypq 174 5 , , , cord-313694-p2sgaypq 174 6 smooth smooth JJ cord-313694-p2sgaypq 174 7 endoplasmic endoplasmic NN cord-313694-p2sgaypq 174 8 reticulum reticulum NN cord-313694-p2sgaypq 174 9 , , , cord-313694-p2sgaypq 174 10 and and CC cord-313694-p2sgaypq 174 11 nuclear nuclear JJ cord-313694-p2sgaypq 174 12 envelope envelope NN cord-313694-p2sgaypq 174 13 are be VBP cord-313694-p2sgaypq 174 14 also also RB cord-313694-p2sgaypq 174 15 intracellular intracellular JJ cord-313694-p2sgaypq 174 16 destinations destination NNS cord-313694-p2sgaypq 174 17 for for IN cord-313694-p2sgaypq 174 18 proteins protein NNS cord-313694-p2sgaypq 174 19 which which WDT cord-313694-p2sgaypq 174 20 traverse traverse VBP cord-313694-p2sgaypq 174 21 the the DT cord-313694-p2sgaypq 174 22 RER RER NNP cord-313694-p2sgaypq 174 23 cotranslationally cotranslationally NN cord-313694-p2sgaypq 174 24 . . . cord-313694-p2sgaypq 175 1 These these DT cord-313694-p2sgaypq 175 2 compartments compartment NNS cord-313694-p2sgaypq 175 3 contain contain VBP cord-313694-p2sgaypq 175 4 numerous numerous JJ cord-313694-p2sgaypq 175 5 characteristic characteristic JJ cord-313694-p2sgaypq 175 6 and and CC cord-313694-p2sgaypq 175 7 uniquely uniquely RB cord-313694-p2sgaypq 175 8 distributed distribute VBN cord-313694-p2sgaypq 175 9 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 175 10 , , , cord-313694-p2sgaypq 175 11 but but CC cord-313694-p2sgaypq 175 12 there there EX cord-313694-p2sgaypq 175 13 is be VBZ cord-313694-p2sgaypq 175 14 not not RB cord-313694-p2sgaypq 175 15 enough enough JJ cord-313694-p2sgaypq 175 16 information information NN cord-313694-p2sgaypq 175 17 to to TO cord-313694-p2sgaypq 175 18 evaluate evaluate VB cord-313694-p2sgaypq 175 19 the the DT cord-313694-p2sgaypq 175 20 possibility possibility NN cord-313694-p2sgaypq 175 21 that that IN cord-313694-p2sgaypq 175 22 carbohydrate carbohydrate NN cord-313694-p2sgaypq 175 23 structure structure NN cord-313694-p2sgaypq 175 24 is be VBZ cord-313694-p2sgaypq 175 25 involved involve VBN cord-313694-p2sgaypq 175 26 in in IN cord-313694-p2sgaypq 175 27 routing route VBG cord-313694-p2sgaypq 175 28 or or CC cord-313694-p2sgaypq 175 29 maintaining maintain VBG cord-313694-p2sgaypq 175 30 the the DT cord-313694-p2sgaypq 175 31 positions position NNS cord-313694-p2sgaypq 175 32 of of IN cord-313694-p2sgaypq 175 33 the the DT cord-313694-p2sgaypq 175 34 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 175 35 . . . cord-313694-p2sgaypq 176 1 Several several JJ cord-313694-p2sgaypq 176 2 cases case NNS cord-313694-p2sgaypq 176 3 of of IN cord-313694-p2sgaypq 176 4 RER rer NN cord-313694-p2sgaypq 176 5 - - HYPH cord-313694-p2sgaypq 176 6 specific specific JJ cord-313694-p2sgaypq 176 7 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 176 8 have have VBP cord-313694-p2sgaypq 176 9 been be VBN cord-313694-p2sgaypq 176 10 considered consider VBN cord-313694-p2sgaypq 176 11 . . . cord-313694-p2sgaypq 177 1 Cells cell NNS cord-313694-p2sgaypq 177 2 infected infect VBN cord-313694-p2sgaypq 177 3 with with IN cord-313694-p2sgaypq 177 4 Rotavirus rotavirus NN cord-313694-p2sgaypq 177 5 synthesize synthesize NN cord-313694-p2sgaypq 177 6 , , , cord-313694-p2sgaypq 177 7 under under IN cord-313694-p2sgaypq 177 8 control control NN cord-313694-p2sgaypq 177 9 of of IN cord-313694-p2sgaypq 177 10 the the DT cord-313694-p2sgaypq 177 11 virus virus NN cord-313694-p2sgaypq 177 12 , , , cord-313694-p2sgaypq 177 13 several several JJ cord-313694-p2sgaypq 177 14 proteins protein NNS cord-313694-p2sgaypq 177 15 including include VBG cord-313694-p2sgaypq 177 16 VP7 vp7 NN cord-313694-p2sgaypq 177 17 , , , cord-313694-p2sgaypq 177 18 an an DT cord-313694-p2sgaypq 177 19 integral integral JJ cord-313694-p2sgaypq 177 20 membrane membrane NN cord-313694-p2sgaypq 177 21 glycoprotein glycoprotein NN cord-313694-p2sgaypq 177 22 whose whose WP$ cord-313694-p2sgaypq 177 23 distribution distribution NN cord-313694-p2sgaypq 177 24 is be VBZ cord-313694-p2sgaypq 177 25 restricted restrict VBN cord-313694-p2sgaypq 177 26 to to IN cord-313694-p2sgaypq 177 27 the the DT cord-313694-p2sgaypq 177 28 RER RER NNP cord-313694-p2sgaypq 177 29 ( ( -LRB- cord-313694-p2sgaypq 177 30 95 95 CD cord-313694-p2sgaypq 177 31 ) ) -RRB- cord-313694-p2sgaypq 177 32 . . . cord-313694-p2sgaypq 178 1 This this DT cord-313694-p2sgaypq 178 2 protein protein NN cord-313694-p2sgaypq 178 3 together together RB cord-313694-p2sgaypq 178 4 with with IN cord-313694-p2sgaypq 178 5 the the DT cord-313694-p2sgaypq 178 6 membrane membrane NN cord-313694-p2sgaypq 178 7 of of IN cord-313694-p2sgaypq 178 8 the the DT cord-313694-p2sgaypq 178 9 RER RER NNP cord-313694-p2sgaypq 178 10 form form VBP cord-313694-p2sgaypq 178 11 a a DT cord-313694-p2sgaypq 178 12 temporary temporary JJ cord-313694-p2sgaypq 178 13 coat coat NN cord-313694-p2sgaypq 178 14 for for IN cord-313694-p2sgaypq 178 15 the the DT cord-313694-p2sgaypq 178 16 virus virus NN cord-313694-p2sgaypq 178 17 . . . cord-313694-p2sgaypq 179 1 In in IN cord-313694-p2sgaypq 179 2 a a DT cord-313694-p2sgaypq 179 3 genetically genetically RB cord-313694-p2sgaypq 179 4 modified modify VBN cord-313694-p2sgaypq 179 5 form form NN cord-313694-p2sgaypq 179 6 of of IN cord-313694-p2sgaypq 179 7 VP7 vp7 NN cord-313694-p2sgaypq 179 8 , , , cord-313694-p2sgaypq 179 9 a a DT cord-313694-p2sgaypq 179 10 hydrophobic hydrophobic JJ cord-313694-p2sgaypq 179 11 region region NN cord-313694-p2sgaypq 179 12 , , , cord-313694-p2sgaypq 179 13 which which WDT cord-313694-p2sgaypq 179 14 presumably presumably RB cord-313694-p2sgaypq 179 15 serves serve VBZ cord-313694-p2sgaypq 179 16 as as IN cord-313694-p2sgaypq 179 17 a a DT cord-313694-p2sgaypq 179 18 transmembrane transmembrane NN cord-313694-p2sgaypq 179 19 anchor anchor NN cord-313694-p2sgaypq 179 20 defining define VBG cord-313694-p2sgaypq 179 21 the the DT cord-313694-p2sgaypq 179 22 proteins protein NNS cord-313694-p2sgaypq 179 23 as as IN cord-313694-p2sgaypq 179 24 an an DT cord-313694-p2sgaypq 179 25 integral integral JJ cord-313694-p2sgaypq 179 26 membrane membrane NN cord-313694-p2sgaypq 179 27 glycoprotein glycoprotein NN cord-313694-p2sgaypq 179 28 , , , cord-313694-p2sgaypq 179 29 was be VBD cord-313694-p2sgaypq 179 30 deleted delete VBN cord-313694-p2sgaypq 179 31 . . . cord-313694-p2sgaypq 180 1 The the DT cord-313694-p2sgaypq 180 2 truncated truncated JJ cord-313694-p2sgaypq 180 3 gene gene NN cord-313694-p2sgaypq 180 4 encoding encoding NN cord-313694-p2sgaypq 180 5 VP7 vp7 NN cord-313694-p2sgaypq 180 6 was be VBD cord-313694-p2sgaypq 180 7 introduced introduce VBN cord-313694-p2sgaypq 180 8 to to IN cord-313694-p2sgaypq 180 9 cells cell NNS cord-313694-p2sgaypq 180 10 by by IN cord-313694-p2sgaypq 180 11 transfection transfection NN cord-313694-p2sgaypq 180 12 . . . cord-313694-p2sgaypq 181 1 Truncated truncated JJ cord-313694-p2sgaypq 181 2 VP7 vp7 NN cord-313694-p2sgaypq 181 3 was be VBD cord-313694-p2sgaypq 181 4 synthesized synthesize VBN cord-313694-p2sgaypq 181 5 , , , cord-313694-p2sgaypq 181 6 but but CC cord-313694-p2sgaypq 181 7 was be VBD cord-313694-p2sgaypq 181 8 then then RB cord-313694-p2sgaypq 181 9 secreted secrete VBN cord-313694-p2sgaypq 181 10 despite despite IN cord-313694-p2sgaypq 181 11 this this DT cord-313694-p2sgaypq 181 12 fact fact NN cord-313694-p2sgaypq 181 13 that that IN cord-313694-p2sgaypq 181 14 glycosylation glycosylation NN cord-313694-p2sgaypq 181 15 at at IN cord-313694-p2sgaypq 181 16 its -PRON- PRP$ cord-313694-p2sgaypq 181 17 single single JJ cord-313694-p2sgaypq 181 18 site site NN cord-313694-p2sgaypq 181 19 toward toward IN cord-313694-p2sgaypq 181 20 the the DT cord-313694-p2sgaypq 181 21 C C NNP cord-313694-p2sgaypq 181 22 - - HYPH cord-313694-p2sgaypq 181 23 terminus terminus NN cord-313694-p2sgaypq 181 24 retained retain VBD cord-313694-p2sgaypq 181 25 its -PRON- PRP$ cord-313694-p2sgaypq 181 26 high high JJ cord-313694-p2sgaypq 181 27 - - HYPH cord-313694-p2sgaypq 181 28 mannose mannose NN cord-313694-p2sgaypq 181 29 character character NN cord-313694-p2sgaypq 181 30 . . . cord-313694-p2sgaypq 182 1 These these DT cord-313694-p2sgaypq 182 2 results result NNS cord-313694-p2sgaypq 182 3 show show VBP cord-313694-p2sgaypq 182 4 that that IN cord-313694-p2sgaypq 182 5 the the DT cord-313694-p2sgaypq 182 6 key key JJ cord-313694-p2sgaypq 182 7 factor factor NN cord-313694-p2sgaypq 182 8 which which WDT cord-313694-p2sgaypq 182 9 retained retain VBD cord-313694-p2sgaypq 182 10 the the DT cord-313694-p2sgaypq 182 11 glycoprotein glycoprotein NN cord-313694-p2sgaypq 182 12 in in IN cord-313694-p2sgaypq 182 13 the the DT cord-313694-p2sgaypq 182 14 RER RER NNP cord-313694-p2sgaypq 182 15 was be VBD cord-313694-p2sgaypq 182 16 the the DT cord-313694-p2sgaypq 182 17 transmembrane transmembrane NN cord-313694-p2sgaypq 182 18 sequence sequence NN cord-313694-p2sgaypq 182 19 and and CC cord-313694-p2sgaypq 182 20 was be VBD cord-313694-p2sgaypq 182 21 not not RB cord-313694-p2sgaypq 182 22 related relate VBN cord-313694-p2sgaypq 182 23 to to IN cord-313694-p2sgaypq 182 24 the the DT cord-313694-p2sgaypq 182 25 glycosylation glycosylation NN cord-313694-p2sgaypq 182 26 site site NN cord-313694-p2sgaypq 182 27 . . . cord-313694-p2sgaypq 183 1 The the DT cord-313694-p2sgaypq 183 2 results result NNS cord-313694-p2sgaypq 183 3 would would MD cord-313694-p2sgaypq 183 4 also also RB cord-313694-p2sgaypq 183 5 imply imply VB cord-313694-p2sgaypq 183 6 that that IN cord-313694-p2sgaypq 183 7 glycosylation glycosylation NN cord-313694-p2sgaypq 183 8 is be VBZ cord-313694-p2sgaypq 183 9 not not RB cord-313694-p2sgaypq 183 10 essential essential JJ cord-313694-p2sgaypq 183 11 to to IN cord-313694-p2sgaypq 183 12 the the DT cord-313694-p2sgaypq 183 13 process process NN cord-313694-p2sgaypq 183 14 of of IN cord-313694-p2sgaypq 183 15 secretion secretion NN cord-313694-p2sgaypq 183 16 . . . cord-313694-p2sgaypq 184 1 Several several JJ cord-313694-p2sgaypq 184 2 nuclear nuclear JJ cord-313694-p2sgaypq 184 3 envelope envelope NN cord-313694-p2sgaypq 184 4 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 184 5 have have VBP cord-313694-p2sgaypq 184 6 been be VBN cord-313694-p2sgaypq 184 7 found find VBN cord-313694-p2sgaypq 184 8 to to TO cord-313694-p2sgaypq 184 9 express express VB cord-313694-p2sgaypq 184 10 an an DT cord-313694-p2sgaypq 184 11 unusual unusual JJ cord-313694-p2sgaypq 184 12 carbohydrate carbohydrate NN cord-313694-p2sgaypq 184 13 structure structure NN cord-313694-p2sgaypq 184 14 consisting consist VBG cord-313694-p2sgaypq 184 15 of of IN cord-313694-p2sgaypq 184 16 GlcNAc GlcNAc NNP cord-313694-p2sgaypq 184 17 - - HYPH cord-313694-p2sgaypq 184 18 asn asn NNP cord-313694-p2sgaypq 184 19 ( ( -LRB- cord-313694-p2sgaypq 184 20 19 19 CD cord-313694-p2sgaypq 184 21 ) ) -RRB- cord-313694-p2sgaypq 184 22 , , , cord-313694-p2sgaypq 184 23 which which WDT cord-313694-p2sgaypq 184 24 is be VBZ cord-313694-p2sgaypq 184 25 an an DT cord-313694-p2sgaypq 184 26 expected expected JJ cord-313694-p2sgaypq 184 27 product product NN cord-313694-p2sgaypq 184 28 of of IN cord-313694-p2sgaypq 184 29 endo endo NN cord-313694-p2sgaypq 184 30 - - HYPH cord-313694-p2sgaypq 184 31 glycosidic glycosidic JJ cord-313694-p2sgaypq 184 32 degradation degradation NN cord-313694-p2sgaypq 184 33 . . . cord-313694-p2sgaypq 185 1 It -PRON- PRP cord-313694-p2sgaypq 185 2 is be VBZ cord-313694-p2sgaypq 185 3 at at IN cord-313694-p2sgaypq 185 4 present present JJ cord-313694-p2sgaypq 185 5 unknown unknown NN cord-313694-p2sgaypq 185 6 where where WRB cord-313694-p2sgaypq 185 7 this this DT cord-313694-p2sgaypq 185 8 structure structure NN cord-313694-p2sgaypq 185 9 is be VBZ cord-313694-p2sgaypq 185 10 synthesized synthesize VBN cord-313694-p2sgaypq 185 11 and and CC cord-313694-p2sgaypq 185 12 thus thus RB cord-313694-p2sgaypq 185 13 whether whether IN cord-313694-p2sgaypq 185 14 glycosylation glycosylation NN cord-313694-p2sgaypq 185 15 precedes precede VBZ cord-313694-p2sgaypq 185 16 or or CC cord-313694-p2sgaypq 185 17 follows follow VBZ cord-313694-p2sgaypq 185 18 arrival arrival NN cord-313694-p2sgaypq 185 19 into into IN cord-313694-p2sgaypq 185 20 the the DT cord-313694-p2sgaypq 185 21 nuclear nuclear JJ cord-313694-p2sgaypq 185 22 envelope envelope NN cord-313694-p2sgaypq 185 23 . . . cord-313694-p2sgaypq 186 1 The the DT cord-313694-p2sgaypq 186 2 secretion secretion NN cord-313694-p2sgaypq 186 3 of of IN cord-313694-p2sgaypq 186 4 protein protein NN cord-313694-p2sgaypq 186 5 appears appear VBZ cord-313694-p2sgaypq 186 6 to to TO cord-313694-p2sgaypq 186 7 involve involve VB cord-313694-p2sgaypq 186 8 at at RB cord-313694-p2sgaypq 186 9 least least RBS cord-313694-p2sgaypq 186 10 two two CD cord-313694-p2sgaypq 186 11 pathways pathway NNS cord-313694-p2sgaypq 186 12 : : : cord-313694-p2sgaypq 186 13 a a DT cord-313694-p2sgaypq 186 14 constitutive constitutive JJ cord-313694-p2sgaypq 186 15 pathway pathway NN cord-313694-p2sgaypq 186 16 and and CC cord-313694-p2sgaypq 186 17 a a DT cord-313694-p2sgaypq 186 18 pathway pathway NN cord-313694-p2sgaypq 186 19 which which WDT cord-313694-p2sgaypq 186 20 includes include VBZ cord-313694-p2sgaypq 186 21 a a DT cord-313694-p2sgaypq 186 22 secretory secretory JJ cord-313694-p2sgaypq 186 23 vesicle vesicle NN cord-313694-p2sgaypq 186 24 which which WDT cord-313694-p2sgaypq 186 25 is be VBZ cord-313694-p2sgaypq 186 26 stored store VBN cord-313694-p2sgaypq 186 27 cytoplasmically cytoplasmically RB cord-313694-p2sgaypq 186 28 ( ( -LRB- cord-313694-p2sgaypq 186 29 144 144 CD cord-313694-p2sgaypq 186 30 ) ) -RRB- cord-313694-p2sgaypq 186 31 . . . cord-313694-p2sgaypq 187 1 A a DT cord-313694-p2sgaypq 187 2 range range NN cord-313694-p2sgaypq 187 3 of of IN cord-313694-p2sgaypq 187 4 high high JJ cord-313694-p2sgaypq 187 5 mannose mannose NN cord-313694-p2sgaypq 187 6 and and CC cord-313694-p2sgaypq 187 7 complex complex NN cord-313694-p2sgaypq 187 8 bi- bi- JJ cord-313694-p2sgaypq 187 9 , , , cord-313694-p2sgaypq 187 10 tri tri JJ cord-313694-p2sgaypq 187 11 - - HYPH cord-313694-p2sgaypq 187 12 and and CC cord-313694-p2sgaypq 187 13 tetra tetra NNP cord-313694-p2sgaypq 187 14 - - HYPH cord-313694-p2sgaypq 187 15 antennary antennary JJ cord-313694-p2sgaypq 187 16 Nlinked Nlinked NNP cord-313694-p2sgaypq 187 17 structures structure NNS cord-313694-p2sgaypq 187 18 has have VBZ cord-313694-p2sgaypq 187 19 been be VBN cord-313694-p2sgaypq 187 20 observed observe VBN cord-313694-p2sgaypq 187 21 on on IN cord-313694-p2sgaypq 187 22 both both CC cord-313694-p2sgaypq 187 23 secretory secretory NN cord-313694-p2sgaypq 187 24 and and CC cord-313694-p2sgaypq 187 25 plasma plasma NN cord-313694-p2sgaypq 187 26 membrane membrane NN cord-313694-p2sgaypq 187 27 associated associate VBD cord-313694-p2sgaypq 187 28 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 187 29 . . . cord-313694-p2sgaypq 188 1 Most Most JJS cord-313694-p2sgaypq 188 2 studies study NNS cord-313694-p2sgaypq 188 3 have have VBP cord-313694-p2sgaypq 188 4 been be VBN cord-313694-p2sgaypq 188 5 directed direct VBN cord-313694-p2sgaypq 188 6 , , , cord-313694-p2sgaypq 188 7 however however RB cord-313694-p2sgaypq 188 8 , , , cord-313694-p2sgaypq 188 9 toward toward IN cord-313694-p2sgaypq 188 10 N n CD cord-313694-p2sgaypq 188 11 - - HYPH cord-313694-p2sgaypq 188 12 linked link VBN cord-313694-p2sgaypq 188 13 glycans glycan NNS cord-313694-p2sgaypq 188 14 since since IN cord-313694-p2sgaypq 188 15 these these DT cord-313694-p2sgaypq 188 16 structures structure NNS cord-313694-p2sgaypq 188 17 are be VBP cord-313694-p2sgaypq 188 18 easier easy JJR cord-313694-p2sgaypq 188 19 to to TO cord-313694-p2sgaypq 188 20 modify modify VB cord-313694-p2sgaypq 188 21 and and CC cord-313694-p2sgaypq 188 22 detect detect VB cord-313694-p2sgaypq 188 23 than than IN cord-313694-p2sgaypq 188 24 are be VBP cord-313694-p2sgaypq 188 25 Olinked Olinked NNP cord-313694-p2sgaypq 188 26 and and CC cord-313694-p2sgaypq 188 27 other other JJ cord-313694-p2sgaypq 188 28 , , , cord-313694-p2sgaypq 188 29 unknown unknown JJ cord-313694-p2sgaypq 188 30 structures structure NNS cord-313694-p2sgaypq 188 31 . . . cord-313694-p2sgaypq 189 1 One one CD cord-313694-p2sgaypq 189 2 approach approach NN cord-313694-p2sgaypq 189 3 to to TO cord-313694-p2sgaypq 189 4 evaluate evaluate VB cord-313694-p2sgaypq 189 5 the the DT cord-313694-p2sgaypq 189 6 potential potential JJ cord-313694-p2sgaypq 189 7 role role NN cord-313694-p2sgaypq 189 8 of of IN cord-313694-p2sgaypq 189 9 Nlinked Nlinked NNP cord-313694-p2sgaypq 189 10 glycans glycan NNS cord-313694-p2sgaypq 189 11 has have VBZ cord-313694-p2sgaypq 189 12 involved involve VBN cord-313694-p2sgaypq 189 13 the the DT cord-313694-p2sgaypq 189 14 use use NN cord-313694-p2sgaypq 189 15 of of IN cord-313694-p2sgaypq 189 16 pharmacological pharmacological JJ cord-313694-p2sgaypq 189 17 inhibitors inhibitor NNS cord-313694-p2sgaypq 189 18 of of IN cord-313694-p2sgaypq 189 19 several several JJ cord-313694-p2sgaypq 189 20 steps step NNS cord-313694-p2sgaypq 189 21 , , , cord-313694-p2sgaypq 189 22 namely namely RB cord-313694-p2sgaypq 189 23 the the DT cord-313694-p2sgaypq 189 24 initial initial JJ cord-313694-p2sgaypq 189 25 steps step NNS cord-313694-p2sgaypq 189 26 of of IN cord-313694-p2sgaypq 189 27 synthesis synthesis NN cord-313694-p2sgaypq 189 28 , , , cord-313694-p2sgaypq 189 29 and and CC cord-313694-p2sgaypq 189 30 deglucosylation deglucosylation NN cord-313694-p2sgaypq 189 31 and and CC cord-313694-p2sgaypq 189 32 demannosylation demannosylation NN cord-313694-p2sgaypq 189 33 . . . cord-313694-p2sgaypq 190 1 Tunicamycin Tunicamycin NNP cord-313694-p2sgaypq 190 2 blocks block VBZ cord-313694-p2sgaypq 190 3 N N NNP cord-313694-p2sgaypq 190 4 - - HYPH cord-313694-p2sgaypq 190 5 linked link VBN cord-313694-p2sgaypq 190 6 glycosylation glycosylation NN cord-313694-p2sgaypq 190 7 completely completely RB cord-313694-p2sgaypq 190 8 ( ( -LRB- cord-313694-p2sgaypq 190 9 as as RB cord-313694-p2sgaypq 190 10 well well RB cord-313694-p2sgaypq 190 11 , , , cord-313694-p2sgaypq 190 12 possibly possibly RB cord-313694-p2sgaypq 190 13 , , , cord-313694-p2sgaypq 190 14 as as IN cord-313694-p2sgaypq 190 15 other other JJ cord-313694-p2sgaypq 190 16 types type NNS cord-313694-p2sgaypq 190 17 of of IN cord-313694-p2sgaypq 190 18 glycosylation glycosylation NN cord-313694-p2sgaypq 190 19 ( ( -LRB- cord-313694-p2sgaypq 190 20 15 15 CD cord-313694-p2sgaypq 190 21 ) ) -RRB- cord-313694-p2sgaypq 190 22 ) ) -RRB- cord-313694-p2sgaypq 190 23 , , , cord-313694-p2sgaypq 190 24 whereas whereas IN cord-313694-p2sgaypq 190 25 deoxynojirimycin deoxynojirimycin NNS cord-313694-p2sgaypq 190 26 and and CC cord-313694-p2sgaypq 190 27 swainsonine swainsonine NN cord-313694-p2sgaypq 190 28 block block NN cord-313694-p2sgaypq 190 29 certain certain JJ cord-313694-p2sgaypq 190 30 steps step NNS cord-313694-p2sgaypq 190 31 leading lead VBG cord-313694-p2sgaypq 190 32 from from IN cord-313694-p2sgaypq 190 33 high high JJ cord-313694-p2sgaypq 190 34 mannose mannose NN cord-313694-p2sgaypq 190 35 structures structure NNS cord-313694-p2sgaypq 190 36 to to IN cord-313694-p2sgaypq 190 37 the the DT cord-313694-p2sgaypq 190 38 complex complex JJ cord-313694-p2sgaypq 190 39 type type NN cord-313694-p2sgaypq 190 40 . . . cord-313694-p2sgaypq 191 1 Though though IN cord-313694-p2sgaypq 191 2 the the DT cord-313694-p2sgaypq 191 3 effects effect NNS cord-313694-p2sgaypq 191 4 are be VBP cord-313694-p2sgaypq 191 5 not not RB cord-313694-p2sgaypq 191 6 simple simple JJ cord-313694-p2sgaypq 191 7 it -PRON- PRP cord-313694-p2sgaypq 191 8 tentatively tentatively RB cord-313694-p2sgaypq 191 9 appears appear VBZ cord-313694-p2sgaypq 191 10 that that IN cord-313694-p2sgaypq 191 11 lack lack NN cord-313694-p2sgaypq 191 12 of of IN cord-313694-p2sgaypq 191 13 N n NN cord-313694-p2sgaypq 191 14 - - HYPH cord-313694-p2sgaypq 191 15 linked link VBN cord-313694-p2sgaypq 191 16 glycosylation glycosylation NN cord-313694-p2sgaypq 191 17 has have VBZ cord-313694-p2sgaypq 191 18 a a DT cord-313694-p2sgaypq 191 19 measureable measureable JJ cord-313694-p2sgaypq 191 20 affect affect NN cord-313694-p2sgaypq 191 21 on on IN cord-313694-p2sgaypq 191 22 the the DT cord-313694-p2sgaypq 191 23 rate rate NN cord-313694-p2sgaypq 191 24 of of IN cord-313694-p2sgaypq 191 25 secretion secretion NN cord-313694-p2sgaypq 191 26 of of IN cord-313694-p2sgaypq 191 27 some some DT cord-313694-p2sgaypq 191 28 proteins protein NNS cord-313694-p2sgaypq 191 29 from from IN cord-313694-p2sgaypq 191 30 hepatocytes hepatocyte NNS cord-313694-p2sgaypq 191 31 or or CC cord-313694-p2sgaypq 191 32 hepatoma hepatoma NNP cord-313694-p2sgaypq 191 33 cells cell NNS cord-313694-p2sgaypq 191 34 ( ( -LRB- cord-313694-p2sgaypq 191 35 82 82 CD cord-313694-p2sgaypq 191 36 , , , cord-313694-p2sgaypq 191 37 85 85 CD cord-313694-p2sgaypq 191 38 , , , cord-313694-p2sgaypq 191 39 84 84 CD cord-313694-p2sgaypq 191 40 ) ) -RRB- cord-313694-p2sgaypq 191 41 . . . cord-313694-p2sgaypq 192 1 Secretion secretion NN cord-313694-p2sgaypq 192 2 from from IN cord-313694-p2sgaypq 192 3 these these DT cord-313694-p2sgaypq 192 4 cells cell NNS cord-313694-p2sgaypq 192 5 appears appear VBZ cord-313694-p2sgaypq 192 6 not not RB cord-313694-p2sgaypq 192 7 to to TO cord-313694-p2sgaypq 192 8 involve involve VB cord-313694-p2sgaypq 192 9 a a DT cord-313694-p2sgaypq 192 10 stored store VBN cord-313694-p2sgaypq 192 11 secretory secretory JJ cord-313694-p2sgaypq 192 12 vesicle vesicle NN cord-313694-p2sgaypq 192 13 . . . cord-313694-p2sgaypq 193 1 Modification modification NN cord-313694-p2sgaypq 193 2 of of IN cord-313694-p2sgaypq 193 3 glycosylation glycosylation NN cord-313694-p2sgaypq 193 4 by by IN cord-313694-p2sgaypq 193 5 deoxynojirimycin deoxynojirimycin NNS cord-313694-p2sgaypq 193 6 or or CC cord-313694-p2sgaypq 193 7 swainsonine swainsonine NN cord-313694-p2sgaypq 193 8 appears appear VBZ cord-313694-p2sgaypq 193 9 in in IN cord-313694-p2sgaypq 193 10 some some DT cord-313694-p2sgaypq 193 11 cases case NNS cord-313694-p2sgaypq 193 12 to to TO cord-313694-p2sgaypq 193 13 affect affect VB cord-313694-p2sgaypq 193 14 the the DT cord-313694-p2sgaypq 193 15 rate rate NN cord-313694-p2sgaypq 193 16 of of IN cord-313694-p2sgaypq 193 17 movement movement NN cord-313694-p2sgaypq 193 18 from from IN cord-313694-p2sgaypq 193 19 the the DT cord-313694-p2sgaypq 193 20 RER RER NNP cord-313694-p2sgaypq 193 21 to to IN cord-313694-p2sgaypq 193 22 the the DT cord-313694-p2sgaypq 193 23 Golgi Golgi NNP cord-313694-p2sgaypq 193 24 and and CC cord-313694-p2sgaypq 193 25 , , , cord-313694-p2sgaypq 193 26 in in IN cord-313694-p2sgaypq 193 27 other other JJ cord-313694-p2sgaypq 193 28 cases case NNS cord-313694-p2sgaypq 193 29 , , , cord-313694-p2sgaypq 193 30 from from IN cord-313694-p2sgaypq 193 31 the the DT cord-313694-p2sgaypq 193 32 Golgi Golgi NNP cord-313694-p2sgaypq 193 33 to to IN cord-313694-p2sgaypq 193 34 the the DT cord-313694-p2sgaypq 193 35 extracellular extracellular JJ cord-313694-p2sgaypq 193 36 space space NN cord-313694-p2sgaypq 193 37 ( ( -LRB- cord-313694-p2sgaypq 193 38 162 162 CD cord-313694-p2sgaypq 193 39 , , , cord-313694-p2sgaypq 193 40 159 159 CD cord-313694-p2sgaypq 193 41 , , , cord-313694-p2sgaypq 193 42 84 84 CD cord-313694-p2sgaypq 193 43 ) ) -RRB- cord-313694-p2sgaypq 193 44 . . . cord-313694-p2sgaypq 194 1 Some some DT cord-313694-p2sgaypq 194 2 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 194 3 and and CC cord-313694-p2sgaypq 194 4 albumin albumin NN cord-313694-p2sgaypq 194 5 are be VBP cord-313694-p2sgaypq 194 6 not not RB cord-313694-p2sgaypq 194 7 affected affect VBN cord-313694-p2sgaypq 194 8 at at RB cord-313694-p2sgaypq 194 9 all all RB cord-313694-p2sgaypq 194 10 . . . cord-313694-p2sgaypq 195 1 This this DT cord-313694-p2sgaypq 195 2 result result NN cord-313694-p2sgaypq 195 3 has have VBZ cord-313694-p2sgaypq 195 4 led lead VBN cord-313694-p2sgaypq 195 5 to to IN cord-313694-p2sgaypq 195 6 speculation speculation NN cord-313694-p2sgaypq 195 7 that that IN cord-313694-p2sgaypq 195 8 there there EX cord-313694-p2sgaypq 195 9 is be VBZ cord-313694-p2sgaypq 195 10 a a DT cord-313694-p2sgaypq 195 11 receptor receptor NN cord-313694-p2sgaypq 195 12 which which WDT cord-313694-p2sgaypq 195 13 can can MD cord-313694-p2sgaypq 195 14 recognize recognize VB cord-313694-p2sgaypq 195 15 and and CC cord-313694-p2sgaypq 195 16 retain retain VB cord-313694-p2sgaypq 195 17 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 195 18 bearing bear VBG cord-313694-p2sgaypq 195 19 the the DT cord-313694-p2sgaypq 195 20 high high JJ cord-313694-p2sgaypq 195 21 mannose mannose NN cord-313694-p2sgaypq 195 22 marker marker NN cord-313694-p2sgaypq 195 23 . . . cord-313694-p2sgaypq 196 1 This this DT cord-313694-p2sgaypq 196 2 mechanism mechanism NN cord-313694-p2sgaypq 196 3 would would MD cord-313694-p2sgaypq 196 4 not not RB cord-313694-p2sgaypq 196 5 be be VB cord-313694-p2sgaypq 196 6 universal universal JJ cord-313694-p2sgaypq 196 7 for for IN cord-313694-p2sgaypq 196 8 all all DT cord-313694-p2sgaypq 196 9 proteins protein NNS cord-313694-p2sgaypq 196 10 . . . cord-313694-p2sgaypq 197 1 Alternatively alternatively RB cord-313694-p2sgaypq 197 2 , , , cord-313694-p2sgaypq 197 3 these these DT cord-313694-p2sgaypq 197 4 differences difference NNS cord-313694-p2sgaypq 197 5 may may MD cord-313694-p2sgaypq 197 6 reflect reflect VB cord-313694-p2sgaypq 197 7 spurious spurious JJ cord-313694-p2sgaypq 197 8 differences difference NNS cord-313694-p2sgaypq 197 9 in in IN cord-313694-p2sgaypq 197 10 rates rate NNS cord-313694-p2sgaypq 197 11 of of IN cord-313694-p2sgaypq 197 12 dissociation dissociation NN cord-313694-p2sgaypq 197 13 from from IN cord-313694-p2sgaypq 197 14 glycosylation glycosylation NN cord-313694-p2sgaypq 197 15 enzymes enzyme NNS cord-313694-p2sgaypq 197 16 . . . cord-313694-p2sgaypq 198 1 It -PRON- PRP cord-313694-p2sgaypq 198 2 seems seem VBZ cord-313694-p2sgaypq 198 3 reasonable reasonable JJ cord-313694-p2sgaypq 198 4 to to TO cord-313694-p2sgaypq 198 5 consider consider VB cord-313694-p2sgaypq 198 6 that that IN cord-313694-p2sgaypq 198 7 glycans glycan NNS cord-313694-p2sgaypq 198 8 may may MD cord-313694-p2sgaypq 198 9 be be VB cord-313694-p2sgaypq 198 10 designed design VBN cord-313694-p2sgaypq 198 11 to to TO cord-313694-p2sgaypq 198 12 play play VB cord-313694-p2sgaypq 198 13 a a DT cord-313694-p2sgaypq 198 14 modulatory modulatory JJ cord-313694-p2sgaypq 198 15 role role NN cord-313694-p2sgaypq 198 16 in in IN cord-313694-p2sgaypq 198 17 the the DT cord-313694-p2sgaypq 198 18 kinetics kinetic NNS cord-313694-p2sgaypq 198 19 of of IN cord-313694-p2sgaypq 198 20 secretion secretion NN cord-313694-p2sgaypq 198 21 for for IN cord-313694-p2sgaypq 198 22 only only RB cord-313694-p2sgaypq 198 23 selected select VBN cord-313694-p2sgaypq 198 24 proteins protein NNS cord-313694-p2sgaypq 198 25 . . . cord-313694-p2sgaypq 199 1 Since since IN cord-313694-p2sgaypq 199 2 secretion secretion NN cord-313694-p2sgaypq 199 3 of of IN cord-313694-p2sgaypq 199 4 these these DT cord-313694-p2sgaypq 199 5 proteins protein NNS cord-313694-p2sgaypq 199 6 is be VBZ cord-313694-p2sgaypq 199 7 not not RB cord-313694-p2sgaypq 199 8 regulated regulate VBN cord-313694-p2sgaypq 199 9 by by IN cord-313694-p2sgaypq 199 10 storage storage NN cord-313694-p2sgaypq 199 11 in in IN cord-313694-p2sgaypq 199 12 a a DT cord-313694-p2sgaypq 199 13 secretory secretory JJ cord-313694-p2sgaypq 199 14 vesicle vesicle NN cord-313694-p2sgaypq 199 15 , , , cord-313694-p2sgaypq 199 16 this this DT cord-313694-p2sgaypq 199 17 mechanism mechanism NN cord-313694-p2sgaypq 199 18 may may MD cord-313694-p2sgaypq 199 19 be be VB cord-313694-p2sgaypq 199 20 used use VBN cord-313694-p2sgaypq 199 21 by by IN cord-313694-p2sgaypq 199 22 the the DT cord-313694-p2sgaypq 199 23 cell cell NN cord-313694-p2sgaypq 199 24 as as IN cord-313694-p2sgaypq 199 25 a a DT cord-313694-p2sgaypq 199 26 finetuning finetuning NN cord-313694-p2sgaypq 199 27 mechanism mechanism NN cord-313694-p2sgaypq 199 28 for for IN cord-313694-p2sgaypq 199 29 controlling control VBG cord-313694-p2sgaypq 199 30 release release NN cord-313694-p2sgaypq 199 31 of of IN cord-313694-p2sgaypq 199 32 protein protein NN cord-313694-p2sgaypq 199 33 . . . cord-313694-p2sgaypq 200 1 It -PRON- PRP cord-313694-p2sgaypq 200 2 is be VBZ cord-313694-p2sgaypq 200 3 plausible plausible JJ cord-313694-p2sgaypq 200 4 that that IN cord-313694-p2sgaypq 200 5 the the DT cord-313694-p2sgaypq 200 6 passive passive JJ cord-313694-p2sgaypq 200 7 constitutive constitutive JJ cord-313694-p2sgaypq 200 8 pathway pathway NN cord-313694-p2sgaypq 200 9 for for IN cord-313694-p2sgaypq 200 10 secretion secretion NN cord-313694-p2sgaypq 200 11 ( ( -LRB- cord-313694-p2sgaypq 200 12 95 95 CD cord-313694-p2sgaypq 200 13 , , , cord-313694-p2sgaypq 200 14 144 144 CD cord-313694-p2sgaypq 200 15 ) ) -RRB- cord-313694-p2sgaypq 200 16 does do VBZ cord-313694-p2sgaypq 200 17 not not RB cord-313694-p2sgaypq 200 18 involve involve VB cord-313694-p2sgaypq 200 19 carbohydrate carbohydrate NN cord-313694-p2sgaypq 200 20 per per IN cord-313694-p2sgaypq 200 21 se se FW cord-313694-p2sgaypq 200 22 , , , cord-313694-p2sgaypq 200 23 but but CC cord-313694-p2sgaypq 200 24 that that IN cord-313694-p2sgaypq 200 25 modifications modification NNS cord-313694-p2sgaypq 200 26 of of IN cord-313694-p2sgaypq 200 27 this this DT cord-313694-p2sgaypq 200 28 pathway pathway NN cord-313694-p2sgaypq 200 29 or or CC cord-313694-p2sgaypq 200 30 its -PRON- PRP$ cord-313694-p2sgaypq 200 31 kinetics kinetic NNS cord-313694-p2sgaypq 200 32 do do VBP cord-313694-p2sgaypq 200 33 . . . cord-313694-p2sgaypq 201 1 Further further JJ cord-313694-p2sgaypq 201 2 work work NN cord-313694-p2sgaypq 201 3 remains remain VBZ cord-313694-p2sgaypq 201 4 to to TO cord-313694-p2sgaypq 201 5 be be VB cord-313694-p2sgaypq 201 6 done do VBN cord-313694-p2sgaypq 201 7 to to TO cord-313694-p2sgaypq 201 8 compare compare VB cord-313694-p2sgaypq 201 9 carbohydrate carbohydrate NN cord-313694-p2sgaypq 201 10 structure structure NN cord-313694-p2sgaypq 201 11 on on IN cord-313694-p2sgaypq 201 12 different different JJ cord-313694-p2sgaypq 201 13 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 201 14 and and CC cord-313694-p2sgaypq 201 15 to to TO cord-313694-p2sgaypq 201 16 consider consider VB cord-313694-p2sgaypq 201 17 the the DT cord-313694-p2sgaypq 201 18 possible possible JJ cord-313694-p2sgaypq 201 19 involvement involvement NN cord-313694-p2sgaypq 201 20 of of IN cord-313694-p2sgaypq 201 21 neighboring neighbor VBG cord-313694-p2sgaypq 201 22 polypeptide polypeptide NN cord-313694-p2sgaypq 201 23 regions region NNS cord-313694-p2sgaypq 201 24 in in IN cord-313694-p2sgaypq 201 25 the the DT cord-313694-p2sgaypq 201 26 interaction interaction NN cord-313694-p2sgaypq 201 27 with with IN cord-313694-p2sgaypq 201 28 a a DT cord-313694-p2sgaypq 201 29 hypothetical hypothetical JJ cord-313694-p2sgaypq 201 30 receptor receptor NN cord-313694-p2sgaypq 201 31 . . . cord-313694-p2sgaypq 202 1 Entry entry NN cord-313694-p2sgaypq 202 2 of of IN cord-313694-p2sgaypq 202 3 protein protein NN cord-313694-p2sgaypq 202 4 into into IN cord-313694-p2sgaypq 202 5 stored store VBN cord-313694-p2sgaypq 202 6 secretory secretory JJ cord-313694-p2sgaypq 202 7 vesicles vesicle NNS cord-313694-p2sgaypq 202 8 requires require VBZ cord-313694-p2sgaypq 202 9 a a DT cord-313694-p2sgaypq 202 10 specific specific JJ cord-313694-p2sgaypq 202 11 signal signal NN cord-313694-p2sgaypq 202 12 as as IN cord-313694-p2sgaypq 202 13 shown show VBN cord-313694-p2sgaypq 202 14 by by IN cord-313694-p2sgaypq 202 15 the the DT cord-313694-p2sgaypq 202 16 observation observation NN cord-313694-p2sgaypq 202 17 that that IN cord-313694-p2sgaypq 202 18 some some DT cord-313694-p2sgaypq 202 19 hormone hormone NN cord-313694-p2sgaypq 202 20 polypeptides polypeptide NNS cord-313694-p2sgaypq 202 21 produced produce VBN cord-313694-p2sgaypq 202 22 by by IN cord-313694-p2sgaypq 202 23 pituitary pituitary JJ cord-313694-p2sgaypq 202 24 cells cell NNS cord-313694-p2sgaypq 202 25 are be VBP cord-313694-p2sgaypq 202 26 stored store VBN cord-313694-p2sgaypq 202 27 whereas whereas IN cord-313694-p2sgaypq 202 28 others other NNS cord-313694-p2sgaypq 202 29 are be VBP cord-313694-p2sgaypq 202 30 constitutively constitutively RB cord-313694-p2sgaypq 202 31 secreted secrete VBN cord-313694-p2sgaypq 202 32 . . . cord-313694-p2sgaypq 203 1 It -PRON- PRP cord-313694-p2sgaypq 203 2 has have VBZ cord-313694-p2sgaypq 203 3 been be VBN cord-313694-p2sgaypq 203 4 observed observe VBN cord-313694-p2sgaypq 203 5 that that IN cord-313694-p2sgaypq 203 6 peptide peptide NN cord-313694-p2sgaypq 203 7 hormones hormone NNS cord-313694-p2sgaypq 203 8 which which WDT cord-313694-p2sgaypq 203 9 are be VBP cord-313694-p2sgaypq 203 10 stored store VBN cord-313694-p2sgaypq 203 11 in in IN cord-313694-p2sgaypq 203 12 pituitary pituitary JJ cord-313694-p2sgaypq 203 13 gonadotropes gonadotrope NNS cord-313694-p2sgaypq 203 14 and and CC cord-313694-p2sgaypq 203 15 thyrotropes thyrotropes NNP cord-313694-p2sgaypq 203 16 are be VBP cord-313694-p2sgaypq 203 17 sulfated sulfate VBN cord-313694-p2sgaypq 203 18 whereas whereas IN cord-313694-p2sgaypq 203 19 related related JJ cord-313694-p2sgaypq 203 20 peptide peptide JJ cord-313694-p2sgaypq 203 21 hormones hormone NNS cord-313694-p2sgaypq 203 22 released release VBN cord-313694-p2sgaypq 203 23 from from IN cord-313694-p2sgaypq 203 24 placental placental JJ cord-313694-p2sgaypq 203 25 cells cell NNS cord-313694-p2sgaypq 203 26 , , , cord-313694-p2sgaypq 203 27 but but CC cord-313694-p2sgaypq 203 28 not not RB cord-313694-p2sgaypq 203 29 stored store VBN cord-313694-p2sgaypq 203 30 there there RB cord-313694-p2sgaypq 203 31 , , , cord-313694-p2sgaypq 203 32 are be VBP cord-313694-p2sgaypq 203 33 not not RB cord-313694-p2sgaypq 203 34 sulfated sulfated JJ cord-313694-p2sgaypq 203 35 . . . cord-313694-p2sgaypq 204 1 This this DT cord-313694-p2sgaypq 204 2 sulfate sulfate NN cord-313694-p2sgaypq 204 3 has have VBZ cord-313694-p2sgaypq 204 4 subsequently subsequently RB cord-313694-p2sgaypq 204 5 been be VBN cord-313694-p2sgaypq 204 6 shown show VBN cord-313694-p2sgaypq 204 7 to to TO cord-313694-p2sgaypq 204 8 reside reside VB cord-313694-p2sgaypq 204 9 at at IN cord-313694-p2sgaypq 204 10 one one CD cord-313694-p2sgaypq 204 11 or or CC cord-313694-p2sgaypq 204 12 more more RBR cord-313694-p2sgaypq 204 13 non non JJ cord-313694-p2sgaypq 204 14 - - JJ cord-313694-p2sgaypq 204 15 reducing reducing JJ cord-313694-p2sgaypq 204 16 termini terminus NNS cord-313694-p2sgaypq 204 17 of of IN cord-313694-p2sgaypq 204 18 N n NN cord-313694-p2sgaypq 204 19 - - HYPH cord-313694-p2sgaypq 204 20 linked link VBN cord-313694-p2sgaypq 204 21 complex complex JJ cord-313694-p2sgaypq 204 22 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 204 23 in in IN cord-313694-p2sgaypq 204 24 the the DT cord-313694-p2sgaypq 204 25 position position NN cord-313694-p2sgaypq 204 26 usually usually RB cord-313694-p2sgaypq 204 27 occupied occupy VBN cord-313694-p2sgaypq 204 28 by by IN cord-313694-p2sgaypq 204 29 sialic sialic JJ cord-313694-p2sgaypq 204 30 acid acid NN cord-313694-p2sgaypq 204 31 . . . cord-313694-p2sgaypq 205 1 This this DT cord-313694-p2sgaypq 205 2 substitution substitution NN cord-313694-p2sgaypq 205 3 may may MD cord-313694-p2sgaypq 205 4 be be VB cord-313694-p2sgaypq 205 5 directed direct VBN cord-313694-p2sgaypq 205 6 by by IN cord-313694-p2sgaypq 205 7 a a DT cord-313694-p2sgaypq 205 8 substitution substitution NN cord-313694-p2sgaypq 205 9 of of IN cord-313694-p2sgaypq 205 10 the the DT cord-313694-p2sgaypq 205 11 GalNAc galnac NN cord-313694-p2sgaypq 205 12 for for IN cord-313694-p2sgaypq 205 13 underlying underlie VBG cord-313694-p2sgaypq 205 14 Gal Gal NNP cord-313694-p2sgaypq 205 15 ( ( -LRB- cord-313694-p2sgaypq 205 16 156 156 CD cord-313694-p2sgaypq 205 17 ) ) -RRB- cord-313694-p2sgaypq 205 18 . . . cord-313694-p2sgaypq 206 1 The the DT cord-313694-p2sgaypq 206 2 functional functional JJ cord-313694-p2sgaypq 206 3 significance significance NN cord-313694-p2sgaypq 206 4 of of IN cord-313694-p2sgaypq 206 5 the the DT cord-313694-p2sgaypq 206 6 relationship relationship NN cord-313694-p2sgaypq 206 7 between between IN cord-313694-p2sgaypq 206 8 GalNAc GalNAc NNP cord-313694-p2sgaypq 206 9 - - HYPH cord-313694-p2sgaypq 206 10 SO so RB cord-313694-p2sgaypq 206 11 4 4 CD cord-313694-p2sgaypq 206 12 and and CC cord-313694-p2sgaypq 206 13 delivery delivery NN cord-313694-p2sgaypq 206 14 to to IN cord-313694-p2sgaypq 206 15 a a DT cord-313694-p2sgaypq 206 16 vesicle vesicle NN cord-313694-p2sgaypq 206 17 which which WDT cord-313694-p2sgaypq 206 18 is be VBZ cord-313694-p2sgaypq 206 19 stored store VBN cord-313694-p2sgaypq 206 20 cytoplasmically cytoplasmically RB cord-313694-p2sgaypq 206 21 prior prior RB cord-313694-p2sgaypq 206 22 to to IN cord-313694-p2sgaypq 206 23 release release VB cord-313694-p2sgaypq 206 24 by by IN cord-313694-p2sgaypq 206 25 a a DT cord-313694-p2sgaypq 206 26 secretagogue secretagogue NN cord-313694-p2sgaypq 206 27 remains remain VBZ cord-313694-p2sgaypq 206 28 to to TO cord-313694-p2sgaypq 206 29 be be VB cord-313694-p2sgaypq 206 30 explored explore VBN cord-313694-p2sgaypq 206 31 . . . cord-313694-p2sgaypq 207 1 An an DT cord-313694-p2sgaypq 207 2 exception exception NN cord-313694-p2sgaypq 207 3 to to IN cord-313694-p2sgaypq 207 4 this this DT cord-313694-p2sgaypq 207 5 structure structure NN cord-313694-p2sgaypq 207 6 - - HYPH cord-313694-p2sgaypq 207 7 function function NN cord-313694-p2sgaypq 207 8 correlation correlation NN cord-313694-p2sgaypq 207 9 is be VBZ cord-313694-p2sgaypq 207 10 posed pose VBN cord-313694-p2sgaypq 207 11 by by IN cord-313694-p2sgaypq 207 12 human human JJ cord-313694-p2sgaypq 207 13 FSH fsh NN cord-313694-p2sgaypq 207 14 , , , cord-313694-p2sgaypq 207 15 which which WDT cord-313694-p2sgaypq 207 16 is be VBZ cord-313694-p2sgaypq 207 17 stored store VBN cord-313694-p2sgaypq 207 18 in in IN cord-313694-p2sgaypq 207 19 human human JJ cord-313694-p2sgaypq 207 20 pituitary pituitary NN cord-313694-p2sgaypq 207 21 gonadotropes gonadotrope NNS cord-313694-p2sgaypq 207 22 but but CC cord-313694-p2sgaypq 207 23 , , , cord-313694-p2sgaypq 207 24 unlike unlike IN cord-313694-p2sgaypq 207 25 the the DT cord-313694-p2sgaypq 207 26 LH lh NN cord-313694-p2sgaypq 207 27 stored store VBN cord-313694-p2sgaypq 207 28 in in IN cord-313694-p2sgaypq 207 29 these these DT cord-313694-p2sgaypq 207 30 cells cell NNS cord-313694-p2sgaypq 207 31 , , , cord-313694-p2sgaypq 207 32 is be VBZ cord-313694-p2sgaypq 207 33 not not RB cord-313694-p2sgaypq 207 34 sulfated sulfated JJ cord-313694-p2sgaypq 207 35 . . . cord-313694-p2sgaypq 208 1 Possibilities possibility NNS cord-313694-p2sgaypq 208 2 consistent consistent JJ cord-313694-p2sgaypq 208 3 with with IN cord-313694-p2sgaypq 208 4 a a DT cord-313694-p2sgaypq 208 5 role role NN cord-313694-p2sgaypq 208 6 for for IN cord-313694-p2sgaypq 208 7 GalNAc GalNAc NNP cord-313694-p2sgaypq 208 8 - - HYPH cord-313694-p2sgaypq 208 9 SO4 SO4 NNP cord-313694-p2sgaypq 208 10 are be VBP cord-313694-p2sgaypq 208 11 that that IN cord-313694-p2sgaypq 208 12 FSH FSH NNP cord-313694-p2sgaypq 208 13 may may MD cord-313694-p2sgaypq 208 14 segregate segregate VB cord-313694-p2sgaypq 208 15 to to IN cord-313694-p2sgaypq 208 16 a a DT cord-313694-p2sgaypq 208 17 discrete discrete JJ cord-313694-p2sgaypq 208 18 vesicle vesicle NN cord-313694-p2sgaypq 208 19 population population NN cord-313694-p2sgaypq 208 20 relative relative JJ cord-313694-p2sgaypq 208 21 to to IN cord-313694-p2sgaypq 208 22 LH LH NNP cord-313694-p2sgaypq 208 23 , , , cord-313694-p2sgaypq 208 24 or or CC cord-313694-p2sgaypq 208 25 that that IN cord-313694-p2sgaypq 208 26 the the DT cord-313694-p2sgaypq 208 27 two two CD cord-313694-p2sgaypq 208 28 homones homone NNS cord-313694-p2sgaypq 208 29 colocalize colocalize NN cord-313694-p2sgaypq 208 30 and and CC cord-313694-p2sgaypq 208 31 that that IN cord-313694-p2sgaypq 208 32 some some DT cord-313694-p2sgaypq 208 33 intermolecular intermolecular JJ cord-313694-p2sgaypq 208 34 association association NN cord-313694-p2sgaypq 208 35 substitutes substitute NNS cord-313694-p2sgaypq 208 36 for for IN cord-313694-p2sgaypq 208 37 the the DT cord-313694-p2sgaypq 208 38 lack lack NN cord-313694-p2sgaypq 208 39 of of IN cord-313694-p2sgaypq 208 40 this this DT cord-313694-p2sgaypq 208 41 carbohydrate carbohydrate NN cord-313694-p2sgaypq 208 42 modification modification NN cord-313694-p2sgaypq 208 43 . . . cord-313694-p2sgaypq 209 1 There there EX cord-313694-p2sgaypq 209 2 is be VBZ cord-313694-p2sgaypq 209 3 no no DT cord-313694-p2sgaypq 209 4 concensus concensus JJ cord-313694-p2sgaypq 209 5 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 209 6 structure structure NN cord-313694-p2sgaypq 209 7 discovered discover VBN cord-313694-p2sgaypq 209 8 thus thus RB cord-313694-p2sgaypq 209 9 far far RB cord-313694-p2sgaypq 209 10 which which WDT cord-313694-p2sgaypq 209 11 distinguishes distinguish VBZ cord-313694-p2sgaypq 209 12 plasma plasma NN cord-313694-p2sgaypq 209 13 membrane membrane NN cord-313694-p2sgaypq 209 14 from from IN cord-313694-p2sgaypq 209 15 secreted secrete VBN cord-313694-p2sgaypq 209 16 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 209 17 . . . cord-313694-p2sgaypq 210 1 Although although IN cord-313694-p2sgaypq 210 2 this this DT cord-313694-p2sgaypq 210 3 may may MD cord-313694-p2sgaypq 210 4 suggest suggest VB cord-313694-p2sgaypq 210 5 the the DT cord-313694-p2sgaypq 210 6 possibility possibility NN cord-313694-p2sgaypq 210 7 that that IN cord-313694-p2sgaypq 210 8 plasma plasma NN cord-313694-p2sgaypq 210 9 membrane membrane NN cord-313694-p2sgaypq 210 10 and and CC cord-313694-p2sgaypq 210 11 secretory secretory JJ cord-313694-p2sgaypq 210 12 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 210 13 may may MD cord-313694-p2sgaypq 210 14 in in IN cord-313694-p2sgaypq 210 15 fact fact NN cord-313694-p2sgaypq 210 16 share share VB cord-313694-p2sgaypq 210 17 a a DT cord-313694-p2sgaypq 210 18 common common JJ cord-313694-p2sgaypq 210 19 signal signal NN cord-313694-p2sgaypq 210 20 , , , cord-313694-p2sgaypq 210 21 on on IN cord-313694-p2sgaypq 210 22 account account NN cord-313694-p2sgaypq 210 23 of of IN cord-313694-p2sgaypq 210 24 their -PRON- PRP$ cord-313694-p2sgaypq 210 25 topologically topologically RB cord-313694-p2sgaypq 210 26 equivalent equivalent JJ cord-313694-p2sgaypq 210 27 destinations destination NNS cord-313694-p2sgaypq 210 28 , , , cord-313694-p2sgaypq 210 29 inhibitor inhibitor NN cord-313694-p2sgaypq 210 30 experiments experiment NNS cord-313694-p2sgaypq 210 31 have have VBP cord-313694-p2sgaypq 210 32 shown show VBN cord-313694-p2sgaypq 210 33 that that IN cord-313694-p2sgaypq 210 34 an an DT cord-313694-p2sgaypq 210 35 absence absence NN cord-313694-p2sgaypq 210 36 of of IN cord-313694-p2sgaypq 210 37 N n NN cord-313694-p2sgaypq 210 38 - - HYPH cord-313694-p2sgaypq 210 39 linked link VBN cord-313694-p2sgaypq 210 40 glycans glycan NNS cord-313694-p2sgaypq 210 41 does do VBZ cord-313694-p2sgaypq 210 42 not not RB cord-313694-p2sgaypq 210 43 consistently consistently RB cord-313694-p2sgaypq 210 44 block block VB cord-313694-p2sgaypq 210 45 the the DT cord-313694-p2sgaypq 210 46 appearance appearance NN cord-313694-p2sgaypq 210 47 of of IN cord-313694-p2sgaypq 210 48 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 210 49 on on IN cord-313694-p2sgaypq 210 50 the the DT cord-313694-p2sgaypq 210 51 cell cell NN cord-313694-p2sgaypq 210 52 surface surface NN cord-313694-p2sgaypq 210 53 ( ( -LRB- cord-313694-p2sgaypq 210 54 88 88 CD cord-313694-p2sgaypq 210 55 , , , cord-313694-p2sgaypq 210 56 90 90 CD cord-313694-p2sgaypq 210 57 ) ) -RRB- cord-313694-p2sgaypq 210 58 . . . cord-313694-p2sgaypq 211 1 There there EX cord-313694-p2sgaypq 211 2 are be VBP cord-313694-p2sgaypq 211 3 , , , cord-313694-p2sgaypq 211 4 however however RB cord-313694-p2sgaypq 211 5 , , , cord-313694-p2sgaypq 211 6 some some DT cord-313694-p2sgaypq 211 7 instances instance NNS cord-313694-p2sgaypq 211 8 of of IN cord-313694-p2sgaypq 211 9 inhibition inhibition NN cord-313694-p2sgaypq 211 10 ( ( -LRB- cord-313694-p2sgaypq 211 11 86 86 CD cord-313694-p2sgaypq 211 12 , , , cord-313694-p2sgaypq 211 13 87 87 CD cord-313694-p2sgaypq 211 14 , , , cord-313694-p2sgaypq 211 15 89 89 CD cord-313694-p2sgaypq 211 16 , , , cord-313694-p2sgaypq 211 17 ( ( -LRB- cord-313694-p2sgaypq 211 18 91 91 CD cord-313694-p2sgaypq 211 19 ) ) -RRB- cord-313694-p2sgaypq 211 20 ( ( -LRB- cord-313694-p2sgaypq 211 21 92 92 CD cord-313694-p2sgaypq 211 22 ) ) -RRB- cord-313694-p2sgaypq 211 23 ( ( -LRB- cord-313694-p2sgaypq 211 24 93 93 CD cord-313694-p2sgaypq 211 25 ) ) -RRB- cord-313694-p2sgaypq 211 26 , , , cord-313694-p2sgaypq 211 27 which which WDT cord-313694-p2sgaypq 211 28 allow allow VBP cord-313694-p2sgaypq 211 29 for for IN cord-313694-p2sgaypq 211 30 the the DT cord-313694-p2sgaypq 211 31 possibility possibility NN cord-313694-p2sgaypq 211 32 that that IN cord-313694-p2sgaypq 211 33 Nlinked Nlinked NNP cord-313694-p2sgaypq 211 34 glycans glycan NNS cord-313694-p2sgaypq 211 35 may may MD cord-313694-p2sgaypq 211 36 act act VB cord-313694-p2sgaypq 211 37 as as IN cord-313694-p2sgaypq 211 38 a a DT cord-313694-p2sgaypq 211 39 signal signal NN cord-313694-p2sgaypq 211 40 or or CC cord-313694-p2sgaypq 211 41 modulator modulator NN cord-313694-p2sgaypq 211 42 for for IN cord-313694-p2sgaypq 211 43 the the DT cord-313694-p2sgaypq 211 44 export export NN cord-313694-p2sgaypq 211 45 of of IN cord-313694-p2sgaypq 211 46 specific specific JJ cord-313694-p2sgaypq 211 47 proteins protein NNS cord-313694-p2sgaypq 211 48 to to IN cord-313694-p2sgaypq 211 49 the the DT cord-313694-p2sgaypq 211 50 plasma plasma NN cord-313694-p2sgaypq 211 51 membrane membrane NN cord-313694-p2sgaypq 211 52 . . . cord-313694-p2sgaypq 212 1 Alternatively alternatively RB cord-313694-p2sgaypq 212 2 , , , cord-313694-p2sgaypq 212 3 the the DT cord-313694-p2sgaypq 212 4 failure failure NN cord-313694-p2sgaypq 212 5 of of IN cord-313694-p2sgaypq 212 6 a a DT cord-313694-p2sgaypq 212 7 few few JJ cord-313694-p2sgaypq 212 8 altered alter VBN cord-313694-p2sgaypq 212 9 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 212 10 to to TO cord-313694-p2sgaypq 212 11 be be VB cord-313694-p2sgaypq 212 12 exported export VBN cord-313694-p2sgaypq 212 13 may may MD cord-313694-p2sgaypq 212 14 be be VB cord-313694-p2sgaypq 212 15 explained explain VBN cord-313694-p2sgaypq 212 16 by by IN cord-313694-p2sgaypq 212 17 enhanced enhanced JJ cord-313694-p2sgaypq 212 18 proteolysis proteolysis NN cord-313694-p2sgaypq 212 19 , , , cord-313694-p2sgaypq 212 20 by by IN cord-313694-p2sgaypq 212 21 a a DT cord-313694-p2sgaypq 212 22 secondary secondary JJ cord-313694-p2sgaypq 212 23 effect effect NN cord-313694-p2sgaypq 212 24 on on IN cord-313694-p2sgaypq 212 25 conformation conformation NN cord-313694-p2sgaypq 212 26 , , , cord-313694-p2sgaypq 212 27 or or CC cord-313694-p2sgaypq 212 28 by by IN cord-313694-p2sgaypq 212 29 the the DT cord-313694-p2sgaypq 212 30 display display NN cord-313694-p2sgaypq 212 31 of of IN cord-313694-p2sgaypq 212 32 another another DT cord-313694-p2sgaypq 212 33 signal signal NN cord-313694-p2sgaypq 212 34 elsewhere elsewhere RB cord-313694-p2sgaypq 212 35 on on IN cord-313694-p2sgaypq 212 36 the the DT cord-313694-p2sgaypq 212 37 polypeptide polypeptide NN cord-313694-p2sgaypq 212 38 ( ( -LRB- cord-313694-p2sgaypq 212 39 165 165 CD cord-313694-p2sgaypq 212 40 ) ) -RRB- cord-313694-p2sgaypq 212 41 . . . cord-313694-p2sgaypq 213 1 A a DT cord-313694-p2sgaypq 213 2 special special JJ cord-313694-p2sgaypq 213 3 class class NN cord-313694-p2sgaypq 213 4 of of IN cord-313694-p2sgaypq 213 5 extrinsic extrinsic JJ cord-313694-p2sgaypq 213 6 plasma plasma NN cord-313694-p2sgaypq 213 7 membrane membrane NN cord-313694-p2sgaypq 213 8 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 213 9 is be VBZ cord-313694-p2sgaypq 213 10 known know VBN cord-313694-p2sgaypq 213 11 , , , cord-313694-p2sgaypq 213 12 however however RB cord-313694-p2sgaypq 213 13 , , , cord-313694-p2sgaypq 213 14 for for IN cord-313694-p2sgaypq 213 15 which which WDT cord-313694-p2sgaypq 213 16 a a DT cord-313694-p2sgaypq 213 17 glycan glycan NN cord-313694-p2sgaypq 213 18 structure structure NN cord-313694-p2sgaypq 213 19 appears appear VBZ cord-313694-p2sgaypq 213 20 to to TO cord-313694-p2sgaypq 213 21 be be VB cord-313694-p2sgaypq 213 22 significant significant JJ cord-313694-p2sgaypq 213 23 for for IN cord-313694-p2sgaypq 213 24 localization localization NN cord-313694-p2sgaypq 213 25 . . . cord-313694-p2sgaypq 214 1 This this DT cord-313694-p2sgaypq 214 2 includes include VBZ cord-313694-p2sgaypq 214 3 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 214 4 which which WDT cord-313694-p2sgaypq 214 5 are be VBP cord-313694-p2sgaypq 214 6 recognized recognize VBN cord-313694-p2sgaypq 214 7 by by IN cord-313694-p2sgaypq 214 8 the the DT cord-313694-p2sgaypq 214 9 cell cell NN cord-313694-p2sgaypq 214 10 surface surface NN cord-313694-p2sgaypq 214 11 protein protein NN cord-313694-p2sgaypq 214 12 ligatin ligatin NNP cord-313694-p2sgaypq 214 13 , , , cord-313694-p2sgaypq 214 14 which which WDT cord-313694-p2sgaypq 214 15 recognizes recognize VBZ cord-313694-p2sgaypq 214 16 a a DT cord-313694-p2sgaypq 214 17 Man-6-PO4 Man-6-PO4 NNP cord-313694-p2sgaypq 214 18 - - HYPH cord-313694-p2sgaypq 214 19 1-Glc 1-Glc NNP cord-313694-p2sgaypq 214 20 , , , cord-313694-p2sgaypq 214 21 linked link VBN cord-313694-p2sgaypq 214 22 to to IN cord-313694-p2sgaypq 214 23 a a DT cord-313694-p2sgaypq 214 24 highmannose highmannose JJ cord-313694-p2sgaypq 214 25 backbone backbone NN cord-313694-p2sgaypq 214 26 ( ( -LRB- cord-313694-p2sgaypq 214 27 160 160 CD cord-313694-p2sgaypq 214 28 ) ) -RRB- cord-313694-p2sgaypq 214 29 . . . cord-313694-p2sgaypq 215 1 This this DT cord-313694-p2sgaypq 215 2 structure structure NN cord-313694-p2sgaypq 215 3 appears appear VBZ cord-313694-p2sgaypq 215 4 to to TO cord-313694-p2sgaypq 215 5 be be VB cord-313694-p2sgaypq 215 6 important important JJ cord-313694-p2sgaypq 215 7 for for IN cord-313694-p2sgaypq 215 8 the the DT cord-313694-p2sgaypq 215 9 cell cell NN cord-313694-p2sgaypq 215 10 surface surface NN cord-313694-p2sgaypq 215 11 association association NN cord-313694-p2sgaypq 215 12 of of IN cord-313694-p2sgaypq 215 13 these these DT cord-313694-p2sgaypq 215 14 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 215 15 since since IN cord-313694-p2sgaypq 215 16 Glc Glc NNP cord-313694-p2sgaypq 215 17 - - HYPH cord-313694-p2sgaypq 215 18 I I NNP cord-313694-p2sgaypq 215 19 - - HYPH cord-313694-p2sgaypq 215 20 PO4 PO4 NNP cord-313694-p2sgaypq 215 21 can can MD cord-313694-p2sgaypq 215 22 elute elute VB cord-313694-p2sgaypq 215 23 them -PRON- PRP cord-313694-p2sgaypq 215 24 from from IN cord-313694-p2sgaypq 215 25 cells cell NNS cord-313694-p2sgaypq 215 26 and and CC cord-313694-p2sgaypq 215 27 a a DT cord-313694-p2sgaypq 215 28 high high JJ cord-313694-p2sgaypq 215 29 concentration concentration NN cord-313694-p2sgaypq 215 30 of of IN cord-313694-p2sgaypq 215 31 Ca Ca NNP cord-313694-p2sgaypq 215 32 + + CC cord-313694-p2sgaypq 215 33 + + CC cord-313694-p2sgaypq 215 34 , , , cord-313694-p2sgaypq 215 35 which which WDT cord-313694-p2sgaypq 215 36 can can MD cord-313694-p2sgaypq 215 37 elute elute VB cord-313694-p2sgaypq 215 38 ligatin ligatin NNP cord-313694-p2sgaypq 215 39 , , , cord-313694-p2sgaypq 215 40 also also RB cord-313694-p2sgaypq 215 41 elutes elute VBZ cord-313694-p2sgaypq 215 42 the the DT cord-313694-p2sgaypq 215 43 associated associate VBN cord-313694-p2sgaypq 215 44 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 215 45 . . . cord-313694-p2sgaypq 216 1 Glycoproteins glycoprotein NNS cord-313694-p2sgaypq 216 2 associated associate VBN cord-313694-p2sgaypq 216 3 by by IN cord-313694-p2sgaypq 216 4 this this DT cord-313694-p2sgaypq 216 5 mechanism mechanism NN cord-313694-p2sgaypq 216 6 were be VBD cord-313694-p2sgaypq 216 7 first first RB cord-313694-p2sgaypq 216 8 recognized recognize VBN cord-313694-p2sgaypq 216 9 ultrastructurally ultrastructurally NN cord-313694-p2sgaypq 216 10 on on IN cord-313694-p2sgaypq 216 11 the the DT cord-313694-p2sgaypq 216 12 surface surface NN cord-313694-p2sgaypq 216 13 of of IN cord-313694-p2sgaypq 216 14 the the DT cord-313694-p2sgaypq 216 15 intestinal intestinal JJ cord-313694-p2sgaypq 216 16 mucosa mucosa NN cord-313694-p2sgaypq 216 17 of of IN cord-313694-p2sgaypq 216 18 the the DT cord-313694-p2sgaypq 216 19 suckling suckle VBG cord-313694-p2sgaypq 216 20 rat rat NN cord-313694-p2sgaypq 216 21 , , , cord-313694-p2sgaypq 216 22 but but CC cord-313694-p2sgaypq 216 23 have have VBP cord-313694-p2sgaypq 216 24 since since IN cord-313694-p2sgaypq 216 25 been be VBN cord-313694-p2sgaypq 216 26 discovered discover VBN cord-313694-p2sgaypq 216 27 on on IN cord-313694-p2sgaypq 216 28 the the DT cord-313694-p2sgaypq 216 29 surfaces surface NNS cord-313694-p2sgaypq 216 30 of of IN cord-313694-p2sgaypq 216 31 a a DT cord-313694-p2sgaypq 216 32 variety variety NN cord-313694-p2sgaypq 216 33 of of IN cord-313694-p2sgaypq 216 34 cell cell NN cord-313694-p2sgaypq 216 35 types type NNS cord-313694-p2sgaypq 216 36 in in IN cord-313694-p2sgaypq 216 37 sea sea NN cord-313694-p2sgaypq 216 38 urchin urchin NN cord-313694-p2sgaypq 216 39 , , , cord-313694-p2sgaypq 216 40 chicken chicken NN cord-313694-p2sgaypq 216 41 and and CC cord-313694-p2sgaypq 216 42 mouse mouse NN cord-313694-p2sgaypq 216 43 . . . cord-313694-p2sgaypq 217 1 It -PRON- PRP cord-313694-p2sgaypq 217 2 is be VBZ cord-313694-p2sgaypq 217 3 unclear unclear JJ cord-313694-p2sgaypq 217 4 whether whether IN cord-313694-p2sgaypq 217 5 the the DT cord-313694-p2sgaypq 217 6 GIc GIc NNP cord-313694-p2sgaypq 217 7 - - HYPH cord-313694-p2sgaypq 217 8 I I NNP cord-313694-p2sgaypq 217 9 - - HYPH cord-313694-p2sgaypq 217 10 PO PO NNP cord-313694-p2sgaypq 217 11 4 4 CD cord-313694-p2sgaypq 217 12 marker marker NN cord-313694-p2sgaypq 217 13 serves serve VBZ cord-313694-p2sgaypq 217 14 as as IN cord-313694-p2sgaypq 217 15 a a DT cord-313694-p2sgaypq 217 16 routing routing NN cord-313694-p2sgaypq 217 17 signal signal NN cord-313694-p2sgaypq 217 18 for for IN cord-313694-p2sgaypq 217 19 export export NN cord-313694-p2sgaypq 217 20 to to IN cord-313694-p2sgaypq 217 21 the the DT cord-313694-p2sgaypq 217 22 cell cell NN cord-313694-p2sgaypq 217 23 surface surface NN cord-313694-p2sgaypq 217 24 , , , cord-313694-p2sgaypq 217 25 using use VBG cord-313694-p2sgaypq 217 26 ligatin ligatin NNP cord-313694-p2sgaypq 217 27 as as IN cord-313694-p2sgaypq 217 28 an an DT cord-313694-p2sgaypq 217 29 intermediate intermediate JJ cord-313694-p2sgaypq 217 30 carrier carrier NN cord-313694-p2sgaypq 217 31 , , , cord-313694-p2sgaypq 217 32 or or CC cord-313694-p2sgaypq 217 33 whether whether IN cord-313694-p2sgaypq 217 34 it -PRON- PRP cord-313694-p2sgaypq 217 35 serves serve VBZ cord-313694-p2sgaypq 217 36 a a DT cord-313694-p2sgaypq 217 37 recognition recognition NN cord-313694-p2sgaypq 217 38 role role NN cord-313694-p2sgaypq 217 39 for for IN cord-313694-p2sgaypq 217 40 secondary secondary JJ cord-313694-p2sgaypq 217 41 association association NN cord-313694-p2sgaypq 217 42 with with IN cord-313694-p2sgaypq 217 43 the the DT cord-313694-p2sgaypq 217 44 cell cell NN cord-313694-p2sgaypq 217 45 surface surface NN cord-313694-p2sgaypq 217 46 once once IN cord-313694-p2sgaypq 217 47 secretion secretion NN cord-313694-p2sgaypq 217 48 in in IN cord-313694-p2sgaypq 217 49 soluble soluble JJ cord-313694-p2sgaypq 217 50 form form NN cord-313694-p2sgaypq 217 51 has have VBZ cord-313694-p2sgaypq 217 52 already already RB cord-313694-p2sgaypq 217 53 occurred occur VBN cord-313694-p2sgaypq 217 54 . . . cord-313694-p2sgaypq 218 1 Though though IN cord-313694-p2sgaypq 218 2 the the DT cord-313694-p2sgaypq 218 3 identity identity NN cord-313694-p2sgaypq 218 4 of of IN cord-313694-p2sgaypq 218 5 many many JJ cord-313694-p2sgaypq 218 6 of of IN cord-313694-p2sgaypq 218 7 the the DT cord-313694-p2sgaypq 218 8 ligatin ligatin NNP cord-313694-p2sgaypq 218 9 associated associate VBD cord-313694-p2sgaypq 218 10 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 218 11 is be VBZ cord-313694-p2sgaypq 218 12 unknown unknown JJ cord-313694-p2sgaypq 218 13 , , , cord-313694-p2sgaypq 218 14 the the DT cord-313694-p2sgaypq 218 15 first first JJ cord-313694-p2sgaypq 218 16 to to TO cord-313694-p2sgaypq 218 17 be be VB cord-313694-p2sgaypq 218 18 discovered discover VBN cord-313694-p2sgaypq 218 19 in in IN cord-313694-p2sgaypq 218 20 the the DT cord-313694-p2sgaypq 218 21 intestinal intestinal JJ cord-313694-p2sgaypq 218 22 mucosa mucosa NN cord-313694-p2sgaypq 218 23 was be VBD cord-313694-p2sgaypq 218 24 j3-Nacetylhexosaminidase j3-Nacetylhexosaminidase NNP cord-313694-p2sgaypq 218 25 . . . cord-313694-p2sgaypq 219 1 In in IN cord-313694-p2sgaypq 219 2 this this DT cord-313694-p2sgaypq 219 3 case case NN cord-313694-p2sgaypq 219 4 , , , cord-313694-p2sgaypq 219 5 the the DT cord-313694-p2sgaypq 219 6 primary primary JJ cord-313694-p2sgaypq 219 7 function function NN cord-313694-p2sgaypq 219 8 of of IN cord-313694-p2sgaypq 219 9 the the DT cord-313694-p2sgaypq 219 10 glycoprotein glycoprotein NN cord-313694-p2sgaypq 219 11 can can MD cord-313694-p2sgaypq 219 12 be be VB cord-313694-p2sgaypq 219 13 viewed view VBN cord-313694-p2sgaypq 219 14 as as IN cord-313694-p2sgaypq 219 15 an an DT cord-313694-p2sgaypq 219 16 enzymatic enzymatic JJ cord-313694-p2sgaypq 219 17 one one NN cord-313694-p2sgaypq 219 18 . . . cord-313694-p2sgaypq 220 1 The the DT cord-313694-p2sgaypq 220 2 appended appended JJ cord-313694-p2sgaypq 220 3 carbohydrate carbohydrate NN cord-313694-p2sgaypq 220 4 appears appear VBZ cord-313694-p2sgaypq 220 5 to to TO cord-313694-p2sgaypq 220 6 serve serve VB cord-313694-p2sgaypq 220 7 a a DT cord-313694-p2sgaypq 220 8 role role NN cord-313694-p2sgaypq 220 9 in in IN cord-313694-p2sgaypq 220 10 localization localization NN cord-313694-p2sgaypq 220 11 , , , cord-313694-p2sgaypq 220 12 contributing contribute VBG cord-313694-p2sgaypq 220 13 to to IN cord-313694-p2sgaypq 220 14 the the DT cord-313694-p2sgaypq 220 15 spatial spatial JJ cord-313694-p2sgaypq 220 16 organization organization NN cord-313694-p2sgaypq 220 17 of of IN cord-313694-p2sgaypq 220 18 the the DT cord-313694-p2sgaypq 220 19 system system NN cord-313694-p2sgaypq 220 20 . . . cord-313694-p2sgaypq 221 1 Consideration consideration NN cord-313694-p2sgaypq 221 2 of of IN cord-313694-p2sgaypq 221 3 the the DT cord-313694-p2sgaypq 221 4 possible possible JJ cord-313694-p2sgaypq 221 5 role role NN cord-313694-p2sgaypq 221 6 of of IN cord-313694-p2sgaypq 221 7 carbohydrate carbohydrate NN cord-313694-p2sgaypq 221 8 in in IN cord-313694-p2sgaypq 221 9 other other JJ cord-313694-p2sgaypq 221 10 molecular molecular JJ cord-313694-p2sgaypq 221 11 associations association NNS cord-313694-p2sgaypq 221 12 with with IN cord-313694-p2sgaypq 221 13 the the DT cord-313694-p2sgaypq 221 14 plasma plasma NN cord-313694-p2sgaypq 221 15 membrane membrane NN cord-313694-p2sgaypq 221 16 will will MD cord-313694-p2sgaypq 221 17 be be VB cord-313694-p2sgaypq 221 18 considered consider VBN cord-313694-p2sgaypq 221 19 below below RB cord-313694-p2sgaypq 221 20 in in IN cord-313694-p2sgaypq 221 21 sections section NNS cord-313694-p2sgaypq 221 22 on on IN cord-313694-p2sgaypq 221 23 hormone hormone NN cord-313694-p2sgaypq 221 24 - - HYPH cord-313694-p2sgaypq 221 25 receptor receptor NN cord-313694-p2sgaypq 221 26 interactions interaction NNS cord-313694-p2sgaypq 221 27 and and CC cord-313694-p2sgaypq 221 28 cellsubstratum cellsubstratum NNP cord-313694-p2sgaypq 221 29 ( ( -LRB- cord-313694-p2sgaypq 221 30 e.g. e.g. RB cord-313694-p2sgaypq 221 31 , , , cord-313694-p2sgaypq 221 32 extracellular extracellular JJ cord-313694-p2sgaypq 221 33 matrix matrix NN cord-313694-p2sgaypq 221 34 ) ) -RRB- cord-313694-p2sgaypq 221 35 and and CC cord-313694-p2sgaypq 221 36 cell cell NN cord-313694-p2sgaypq 221 37 - - HYPH cord-313694-p2sgaypq 221 38 cell cell NN cord-313694-p2sgaypq 221 39 adhesion adhesion NN cord-313694-p2sgaypq 221 40 . . . cord-313694-p2sgaypq 222 1 It -PRON- PRP cord-313694-p2sgaypq 222 2 has have VBZ cord-313694-p2sgaypq 222 3 been be VBN cord-313694-p2sgaypq 222 4 proposed propose VBN cord-313694-p2sgaypq 222 5 that that IN cord-313694-p2sgaypq 222 6 specific specific JJ cord-313694-p2sgaypq 222 7 carbohydrate carbohydrate NN cord-313694-p2sgaypq 222 8 / / SYM cord-313694-p2sgaypq 222 9 protein protein NN cord-313694-p2sgaypq 222 10 interactions interaction NNS cord-313694-p2sgaypq 222 11 might may MD cord-313694-p2sgaypq 222 12 designate designate VB cord-313694-p2sgaypq 222 13 the the DT cord-313694-p2sgaypq 222 14 localization localization NN cord-313694-p2sgaypq 222 15 of of IN cord-313694-p2sgaypq 222 16 secreted secrete VBN cord-313694-p2sgaypq 222 17 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 222 18 to to IN cord-313694-p2sgaypq 222 19 specific specific JJ cord-313694-p2sgaypq 222 20 sites site NNS cord-313694-p2sgaypq 222 21 in in IN cord-313694-p2sgaypq 222 22 the the DT cord-313694-p2sgaypq 222 23 extracellular extracellular JJ cord-313694-p2sgaypq 222 24 matrix matrix NN cord-313694-p2sgaypq 222 25 ( ( -LRB- cord-313694-p2sgaypq 222 26 3 3 CD cord-313694-p2sgaypq 222 27 ) ) -RRB- cord-313694-p2sgaypq 222 28 . . . cord-313694-p2sgaypq 223 1 This this DT cord-313694-p2sgaypq 223 2 idea idea NN cord-313694-p2sgaypq 223 3 has have VBZ cord-313694-p2sgaypq 223 4 received receive VBN cord-313694-p2sgaypq 223 5 support support NN cord-313694-p2sgaypq 223 6 recently recently RB cord-313694-p2sgaypq 223 7 from from IN cord-313694-p2sgaypq 223 8 the the DT cord-313694-p2sgaypq 223 9 detection detection NN cord-313694-p2sgaypq 223 10 of of IN cord-313694-p2sgaypq 223 11 animal animal NN cord-313694-p2sgaypq 223 12 lectins lectin NNS cord-313694-p2sgaypq 223 13 in in IN cord-313694-p2sgaypq 223 14 matrices matrix NNS cord-313694-p2sgaypq 223 15 , , , cord-313694-p2sgaypq 223 16 basement basement NN cord-313694-p2sgaypq 223 17 membranes membrane NNS cord-313694-p2sgaypq 223 18 , , , cord-313694-p2sgaypq 223 19 and and CC cord-313694-p2sgaypq 223 20 mucous mucous JJ cord-313694-p2sgaypq 223 21 secretions secretion NNS cord-313694-p2sgaypq 223 22 ( ( -LRB- cord-313694-p2sgaypq 223 23 140 140 CD cord-313694-p2sgaypq 223 24 ) ) -RRB- cord-313694-p2sgaypq 223 25 . . . cord-313694-p2sgaypq 224 1 Lectins Lectins NNP cord-313694-p2sgaypq 224 2 , , , cord-313694-p2sgaypq 224 3 which which WDT cord-313694-p2sgaypq 224 4 are be VBP cord-313694-p2sgaypq 224 5 multivalent multivalent JJ cord-313694-p2sgaypq 224 6 carbohydrate carbohydrate NN cord-313694-p2sgaypq 224 7 binding bind VBG cord-313694-p2sgaypq 224 8 proteins protein NNS cord-313694-p2sgaypq 224 9 with with IN cord-313694-p2sgaypq 224 10 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 224 11 specificity specificity NN cord-313694-p2sgaypq 224 12 , , , cord-313694-p2sgaypq 224 13 are be VBP cord-313694-p2sgaypq 224 14 believed believe VBN cord-313694-p2sgaypq 224 15 to to TO cord-313694-p2sgaypq 224 16 crosslink crosslink VB cord-313694-p2sgaypq 224 17 other other JJ cord-313694-p2sgaypq 224 18 molecules molecule NNS cord-313694-p2sgaypq 224 19 to to TO cord-313694-p2sgaypq 224 20 contribute contribute VB cord-313694-p2sgaypq 224 21 to to IN cord-313694-p2sgaypq 224 22 , , , cord-313694-p2sgaypq 224 23 e.g. e.g. RB cord-313694-p2sgaypq 224 24 , , , cord-313694-p2sgaypq 224 25 the the DT cord-313694-p2sgaypq 224 26 viscosity viscosity NN cord-313694-p2sgaypq 224 27 of of IN cord-313694-p2sgaypq 224 28 certain certain JJ cord-313694-p2sgaypq 224 29 mucous mucous JJ cord-313694-p2sgaypq 224 30 structures structure NNS cord-313694-p2sgaypq 224 31 ( ( -LRB- cord-313694-p2sgaypq 224 32 44 44 CD cord-313694-p2sgaypq 224 33 ) ) -RRB- cord-313694-p2sgaypq 224 34 . . . cord-313694-p2sgaypq 225 1 Binding bind VBG cord-313694-p2sgaypq 225 2 of of IN cord-313694-p2sgaypq 225 3 matrix matrix NN cord-313694-p2sgaypq 225 4 proteins protein NNS cord-313694-p2sgaypq 225 5 to to IN cord-313694-p2sgaypq 225 6 carbohydrate carbohydrate NN cord-313694-p2sgaypq 225 7 of of IN cord-313694-p2sgaypq 225 8 GAGs gag NNS cord-313694-p2sgaypq 225 9 has have VBZ cord-313694-p2sgaypq 225 10 been be VBN cord-313694-p2sgaypq 225 11 reported report VBN cord-313694-p2sgaypq 225 12 ( ( -LRB- cord-313694-p2sgaypq 225 13 21 21 CD cord-313694-p2sgaypq 225 14 , , , cord-313694-p2sgaypq 225 15 32 32 CD cord-313694-p2sgaypq 225 16 ) ) -RRB- cord-313694-p2sgaypq 225 17 . . . cord-313694-p2sgaypq 226 1 A a DT cord-313694-p2sgaypq 226 2 recent recent JJ cord-313694-p2sgaypq 226 3 report report NN cord-313694-p2sgaypq 226 4 suggests suggest VBZ cord-313694-p2sgaypq 226 5 that that IN cord-313694-p2sgaypq 226 6 the the DT cord-313694-p2sgaypq 226 7 neural neural JJ cord-313694-p2sgaypq 226 8 adhesion adhesion NN cord-313694-p2sgaypq 226 9 protein protein NN cord-313694-p2sgaypq 226 10 N N NNP cord-313694-p2sgaypq 226 11 - - HYPH cord-313694-p2sgaypq 226 12 CAM CAM NNP cord-313694-p2sgaypq 226 13 has have VBZ cord-313694-p2sgaypq 226 14 a a DT cord-313694-p2sgaypq 226 15 binding binding JJ cord-313694-p2sgaypq 226 16 site site NN cord-313694-p2sgaypq 226 17 for for IN cord-313694-p2sgaypq 226 18 heparan heparan JJ cord-313694-p2sgaypq 226 19 sulfate sulfate NN cord-313694-p2sgaypq 226 20 - - HYPH cord-313694-p2sgaypq 226 21 like like JJ cord-313694-p2sgaypq 226 22 GAGs gag NNS cord-313694-p2sgaypq 226 23 ( ( -LRB- cord-313694-p2sgaypq 226 24 171 171 CD cord-313694-p2sgaypq 226 25 ) ) -RRB- cord-313694-p2sgaypq 226 26 . . . cord-313694-p2sgaypq 227 1 In in IN cord-313694-p2sgaypq 227 2 the the DT cord-313694-p2sgaypq 227 3 early early JJ cord-313694-p2sgaypq 227 4 1970s 1970 NNS cord-313694-p2sgaypq 227 5 , , , cord-313694-p2sgaypq 227 6 Ashwell Ashwell NNP cord-313694-p2sgaypq 227 7 and and CC cord-313694-p2sgaypq 227 8 Morrell Morrell NNP cord-313694-p2sgaypq 227 9 demonstrated demonstrate VBD cord-313694-p2sgaypq 227 10 that that IN cord-313694-p2sgaypq 227 11 desialylation desialylation NN cord-313694-p2sgaypq 227 12 of of IN cord-313694-p2sgaypq 227 13 serum serum NN cord-313694-p2sgaypq 227 14 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 227 15 , , , cord-313694-p2sgaypq 227 16 resulting result VBG cord-313694-p2sgaypq 227 17 in in IN cord-313694-p2sgaypq 227 18 the the DT cord-313694-p2sgaypq 227 19 exposure exposure NN cord-313694-p2sgaypq 227 20 of of IN cord-313694-p2sgaypq 227 21 a a DT cord-313694-p2sgaypq 227 22 penultimate penultimate JJ cord-313694-p2sgaypq 227 23 galactose galactose NN cord-313694-p2sgaypq 227 24 in in IN cord-313694-p2sgaypq 227 25 mammalian mammalian JJ cord-313694-p2sgaypq 227 26 species specie NNS cord-313694-p2sgaypq 227 27 , , , cord-313694-p2sgaypq 227 28 caused cause VBD cord-313694-p2sgaypq 227 29 rapid rapid JJ cord-313694-p2sgaypq 227 30 removal removal NN cord-313694-p2sgaypq 227 31 of of IN cord-313694-p2sgaypq 227 32 proteins protein NNS cord-313694-p2sgaypq 227 33 by by IN cord-313694-p2sgaypq 227 34 hepatocytes hepatocyte NNS cord-313694-p2sgaypq 227 35 once once IN cord-313694-p2sgaypq 227 36 these these DT cord-313694-p2sgaypq 227 37 altered alter VBN cord-313694-p2sgaypq 227 38 proteins protein NNS cord-313694-p2sgaypq 227 39 were be VBD cord-313694-p2sgaypq 227 40 restored restore VBN cord-313694-p2sgaypq 227 41 to to IN cord-313694-p2sgaypq 227 42 the the DT cord-313694-p2sgaypq 227 43 blood blood NN cord-313694-p2sgaypq 227 44 ( ( -LRB- cord-313694-p2sgaypq 227 45 reviewed review VBN cord-313694-p2sgaypq 227 46 in in IN cord-313694-p2sgaypq 227 47 105 105 CD cord-313694-p2sgaypq 227 48 , , , cord-313694-p2sgaypq 227 49 106 106 CD cord-313694-p2sgaypq 227 50 ) ) -RRB- cord-313694-p2sgaypq 227 51 . . . cord-313694-p2sgaypq 228 1 This this DT cord-313694-p2sgaypq 228 2 suggested suggest VBD cord-313694-p2sgaypq 228 3 that that IN cord-313694-p2sgaypq 228 4 normal normal JJ cord-313694-p2sgaypq 228 5 turnover turnover NN cord-313694-p2sgaypq 228 6 of of IN cord-313694-p2sgaypq 228 7 serum serum NN cord-313694-p2sgaypq 228 8 proteins protein NNS cord-313694-p2sgaypq 228 9 is be VBZ cord-313694-p2sgaypq 228 10 regulated regulate VBN cord-313694-p2sgaypq 228 11 by by IN cord-313694-p2sgaypq 228 12 the the DT cord-313694-p2sgaypq 228 13 structure structure NN cord-313694-p2sgaypq 228 14 of of IN cord-313694-p2sgaypq 228 15 their -PRON- PRP$ cord-313694-p2sgaypq 228 16 glycans glycan NNS cord-313694-p2sgaypq 228 17 , , , cord-313694-p2sgaypq 228 18 which which WDT cord-313694-p2sgaypq 228 19 would would MD cord-313694-p2sgaypq 228 20 be be VB cord-313694-p2sgaypq 228 21 regulated regulate VBN cord-313694-p2sgaypq 228 22 by by IN cord-313694-p2sgaypq 228 23 interaction interaction NN cord-313694-p2sgaypq 228 24 with with IN cord-313694-p2sgaypq 228 25 sialidases sialidase NNS cord-313694-p2sgaypq 228 26 . . . cord-313694-p2sgaypq 229 1 Though though IN cord-313694-p2sgaypq 229 2 a a DT cord-313694-p2sgaypq 229 3 carbohydrate carbohydrate NN cord-313694-p2sgaypq 229 4 binding bind VBG cord-313694-p2sgaypq 229 5 receptor receptor NN cord-313694-p2sgaypq 229 6 for for IN cord-313694-p2sgaypq 229 7 ( ( -LRB- cord-313694-p2sgaypq 229 8 non non JJ cord-313694-p2sgaypq 229 9 - - JJ cord-313694-p2sgaypq 229 10 reducing reducing JJ cord-313694-p2sgaypq 229 11 ) ) -RRB- cord-313694-p2sgaypq 229 12 terminal terminal JJ cord-313694-p2sgaypq 229 13 Gal Gal NNP cord-313694-p2sgaypq 229 14 / / SYM cord-313694-p2sgaypq 229 15 GalNAc GalNAc NNP cord-313694-p2sgaypq 229 16 has have VBZ cord-313694-p2sgaypq 229 17 been be VBN cord-313694-p2sgaypq 229 18 characterized characterize VBN cord-313694-p2sgaypq 229 19 in in IN cord-313694-p2sgaypq 229 20 hepatocytes hepatocyte NNS cord-313694-p2sgaypq 229 21 , , , cord-313694-p2sgaypq 229 22 it -PRON- PRP cord-313694-p2sgaypq 229 23 has have VBZ cord-313694-p2sgaypq 229 24 not not RB cord-313694-p2sgaypq 229 25 been be VBN cord-313694-p2sgaypq 229 26 possible possible JJ cord-313694-p2sgaypq 229 27 to to TO cord-313694-p2sgaypq 229 28 prove prove VB cord-313694-p2sgaypq 229 29 this this DT cord-313694-p2sgaypq 229 30 hypothesis hypothesis NN cord-313694-p2sgaypq 229 31 directly directly RB cord-313694-p2sgaypq 229 32 . . . cord-313694-p2sgaypq 230 1 This this DT cord-313694-p2sgaypq 230 2 mechanism mechanism NN cord-313694-p2sgaypq 230 3 is be VBZ cord-313694-p2sgaypq 230 4 not not RB cord-313694-p2sgaypq 230 5 universal universal JJ cord-313694-p2sgaypq 230 6 because because IN cord-313694-p2sgaypq 230 7 not not RB cord-313694-p2sgaypq 230 8 all all DT cord-313694-p2sgaypq 230 9 serum serum NN cord-313694-p2sgaypq 230 10 proteins protein NNS cord-313694-p2sgaypq 230 11 , , , cord-313694-p2sgaypq 230 12 albumin albumin NN cord-313694-p2sgaypq 230 13 being be VBG cord-313694-p2sgaypq 230 14 a a DT cord-313694-p2sgaypq 230 15 notable notable JJ cord-313694-p2sgaypq 230 16 example example NN cord-313694-p2sgaypq 230 17 , , , cord-313694-p2sgaypq 230 18 are be VBP cord-313694-p2sgaypq 230 19 enzymatically enzymatically RB cord-313694-p2sgaypq 230 20 glycosylated glycosylate VBN cord-313694-p2sgaypq 230 21 . . . cord-313694-p2sgaypq 231 1 Further further JJ cord-313694-p2sgaypq 231 2 work work NN cord-313694-p2sgaypq 231 3 must must MD cord-313694-p2sgaypq 231 4 be be VB cord-313694-p2sgaypq 231 5 done do VBN cord-313694-p2sgaypq 231 6 to to TO cord-313694-p2sgaypq 231 7 determine determine VB cord-313694-p2sgaypq 231 8 whether whether IN cord-313694-p2sgaypq 231 9 this this DT cord-313694-p2sgaypq 231 10 system system NN cord-313694-p2sgaypq 231 11 actually actually RB cord-313694-p2sgaypq 231 12 functions function VBZ cord-313694-p2sgaypq 231 13 in in IN cord-313694-p2sgaypq 231 14 serum serum NN cord-313694-p2sgaypq 231 15 protein protein NN cord-313694-p2sgaypq 231 16 turnover turnover NN cord-313694-p2sgaypq 231 17 . . . cord-313694-p2sgaypq 232 1 It -PRON- PRP cord-313694-p2sgaypq 232 2 is be VBZ cord-313694-p2sgaypq 232 3 interesting interesting JJ cord-313694-p2sgaypq 232 4 to to TO cord-313694-p2sgaypq 232 5 note note VB cord-313694-p2sgaypq 232 6 that that IN cord-313694-p2sgaypq 232 7 a a DT cord-313694-p2sgaypq 232 8 family family NN cord-313694-p2sgaypq 232 9 of of IN cord-313694-p2sgaypq 232 10 serum serum NN cord-313694-p2sgaypq 232 11 proteins protein NNS cord-313694-p2sgaypq 232 12 ( ( -LRB- cord-313694-p2sgaypq 232 13 IgA1 iga1 CD cord-313694-p2sgaypq 232 14 ) ) -RRB- cord-313694-p2sgaypq 232 15 binds bind VBZ cord-313694-p2sgaypq 232 16 this this DT cord-313694-p2sgaypq 232 17 receptor receptor NN cord-313694-p2sgaypq 232 18 by by IN cord-313694-p2sgaypq 232 19 way way NN cord-313694-p2sgaypq 232 20 of of IN cord-313694-p2sgaypq 232 21 O o NN cord-313694-p2sgaypq 232 22 - - HYPH cord-313694-p2sgaypq 232 23 linked link VBN cord-313694-p2sgaypq 232 24 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 232 25 , , , cord-313694-p2sgaypq 232 26 but but CC cord-313694-p2sgaypq 232 27 only only RB cord-313694-p2sgaypq 232 28 upon upon IN cord-313694-p2sgaypq 232 29 denaturation denaturation NN cord-313694-p2sgaypq 232 30 ( ( -LRB- cord-313694-p2sgaypq 232 31 175 175 CD cord-313694-p2sgaypq 232 32 ) ) -RRB- cord-313694-p2sgaypq 232 33 . . . cord-313694-p2sgaypq 233 1 It -PRON- PRP cord-313694-p2sgaypq 233 2 has have VBZ cord-313694-p2sgaypq 233 3 also also RB cord-313694-p2sgaypq 233 4 been be VBN cord-313694-p2sgaypq 233 5 recently recently RB cord-313694-p2sgaypq 233 6 shown show VBN cord-313694-p2sgaypq 233 7 that that IN cord-313694-p2sgaypq 233 8 liver liver NN cord-313694-p2sgaypq 233 9 endothelial endothelial JJ cord-313694-p2sgaypq 233 10 cells cell NNS cord-313694-p2sgaypq 233 11 can can MD cord-313694-p2sgaypq 233 12 desialate desialate VB cord-313694-p2sgaypq 233 13 a a DT cord-313694-p2sgaypq 233 14 serum serum NN cord-313694-p2sgaypq 233 15 protein protein NN cord-313694-p2sgaypq 233 16 , , , cord-313694-p2sgaypq 233 17 thus thus RB cord-313694-p2sgaypq 233 18 rendering render VBG cord-313694-p2sgaypq 233 19 it -PRON- PRP cord-313694-p2sgaypq 233 20 susceptible susceptible JJ cord-313694-p2sgaypq 233 21 to to IN cord-313694-p2sgaypq 233 22 uptake uptake NN cord-313694-p2sgaypq 233 23 by by IN cord-313694-p2sgaypq 233 24 hepatocytes hepatocyte NNS cord-313694-p2sgaypq 233 25 via via IN cord-313694-p2sgaypq 233 26 the the DT cord-313694-p2sgaypq 233 27 Gal Gal NNP cord-313694-p2sgaypq 233 28 / / SYM cord-313694-p2sgaypq 233 29 GalNAc galnac NN cord-313694-p2sgaypq 233 30 receptor receptor NN cord-313694-p2sgaypq 233 31 ( ( -LRB- cord-313694-p2sgaypq 233 32 178 178 CD cord-313694-p2sgaypq 233 33 ) ) -RRB- cord-313694-p2sgaypq 233 34 . . . cord-313694-p2sgaypq 234 1 Additional additional JJ cord-313694-p2sgaypq 234 2 studies study NNS cord-313694-p2sgaypq 234 3 have have VBP cord-313694-p2sgaypq 234 4 revealed reveal VBN cord-313694-p2sgaypq 234 5 the the DT cord-313694-p2sgaypq 234 6 presence presence NN cord-313694-p2sgaypq 234 7 of of IN cord-313694-p2sgaypq 234 8 a a DT cord-313694-p2sgaypq 234 9 distinct distinct JJ cord-313694-p2sgaypq 234 10 carbohydrate carbohydrate NN cord-313694-p2sgaypq 234 11 binding bind VBG cord-313694-p2sgaypq 234 12 protein protein NN cord-313694-p2sgaypq 234 13 in in IN cord-313694-p2sgaypq 234 14 Kupffer Kupffer NNP cord-313694-p2sgaypq 234 15 and and CC cord-313694-p2sgaypq 234 16 other other JJ cord-313694-p2sgaypq 234 17 macrophage macrophage NN cord-313694-p2sgaypq 234 18 - - HYPH cord-313694-p2sgaypq 234 19 like like JJ cord-313694-p2sgaypq 234 20 cells cell NNS cord-313694-p2sgaypq 234 21 ( ( -LRB- cord-313694-p2sgaypq 234 22 105 105 CD cord-313694-p2sgaypq 234 23 , , , cord-313694-p2sgaypq 234 24 108 108 CD cord-313694-p2sgaypq 234 25 , , , cord-313694-p2sgaypq 234 26 109 109 CD cord-313694-p2sgaypq 234 27 , , , cord-313694-p2sgaypq 234 28 175 175 CD cord-313694-p2sgaypq 234 29 ) ) -RRB- cord-313694-p2sgaypq 234 30 . . . cord-313694-p2sgaypq 235 1 Following follow VBG cord-313694-p2sgaypq 235 2 recognition recognition NN cord-313694-p2sgaypq 235 3 , , , cord-313694-p2sgaypq 235 4 these these DT cord-313694-p2sgaypq 235 5 and and CC cord-313694-p2sgaypq 235 6 other other JJ cord-313694-p2sgaypq 235 7 carbo carbo NNP cord-313694-p2sgaypq 235 8 - - HYPH cord-313694-p2sgaypq 235 9 hs hs NNP cord-313694-p2sgaypq 235 10 ~ ~ NNP cord-313694-p2sgaypq 235 11 drate drate NNP cord-313694-p2sgaypq 235 12 binding bind VBG cord-313694-p2sgaypq 235 13 proteins protein NNS cord-313694-p2sgaypq 235 14 become become VBP cord-313694-p2sgaypq 235 15 internalized internalize VBN cord-313694-p2sgaypq 235 16 together together RB cord-313694-p2sgaypq 235 17 with with IN cord-313694-p2sgaypq 235 18 their -PRON- PRP$ cord-313694-p2sgaypq 235 19 ligands ligand NNS cord-313694-p2sgaypq 235 20 , , , cord-313694-p2sgaypq 235 21 which which WDT cord-313694-p2sgaypq 235 22 carry carry VBP cord-313694-p2sgaypq 235 23 a a DT cord-313694-p2sgaypq 235 24 Man Man NNP cord-313694-p2sgaypq 235 25 / / SYM cord-313694-p2sgaypq 235 26 GlcNAc GlcNAc NNP cord-313694-p2sgaypq 235 27 / / SYM cord-313694-p2sgaypq 235 28 Fuc Fuc NNP cord-313694-p2sgaypq 235 29 specificity specificity NN cord-313694-p2sgaypq 235 30 , , , cord-313694-p2sgaypq 235 31 but but CC cord-313694-p2sgaypq 235 32 later later RB cord-313694-p2sgaypq 235 33 return return VB cord-313694-p2sgaypq 235 34 to to IN cord-313694-p2sgaypq 235 35 the the DT cord-313694-p2sgaypq 235 36 cell cell NN cord-313694-p2sgaypq 235 37 surface surface NN cord-313694-p2sgaypq 235 38 free free JJ cord-313694-p2sgaypq 235 39 of of IN cord-313694-p2sgaypq 235 40 ligand ligand NN cord-313694-p2sgaypq 235 41 . . . cord-313694-p2sgaypq 236 1 In in IN cord-313694-p2sgaypq 236 2 addition addition NN cord-313694-p2sgaypq 236 3 , , , cord-313694-p2sgaypq 236 4 cell cell NN cord-313694-p2sgaypq 236 5 surface surface NN cord-313694-p2sgaypq 236 6 localized localize VBN cord-313694-p2sgaypq 236 7 Man-6-PO4 Man-6-PO4 NNP cord-313694-p2sgaypq 236 8 receptors receptor NNS cord-313694-p2sgaypq 236 9 have have VBP cord-313694-p2sgaypq 236 10 been be VBN cord-313694-p2sgaypq 236 11 suggested suggest VBN cord-313694-p2sgaypq 236 12 to to TO cord-313694-p2sgaypq 236 13 be be VB cord-313694-p2sgaypq 236 14 responsible responsible JJ cord-313694-p2sgaypq 236 15 for for IN cord-313694-p2sgaypq 236 16 hepatic hepatic JJ cord-313694-p2sgaypq 236 17 uptake uptake NN cord-313694-p2sgaypq 236 18 of of IN cord-313694-p2sgaypq 236 19 enzymes enzyme NNS cord-313694-p2sgaypq 236 20 supplied supply VBN cord-313694-p2sgaypq 236 21 to to IN cord-313694-p2sgaypq 236 22 the the DT cord-313694-p2sgaypq 236 23 fetal fetal JJ cord-313694-p2sgaypq 236 24 blood blood NN cord-313694-p2sgaypq 236 25 from from IN cord-313694-p2sgaypq 236 26 placental placental JJ cord-313694-p2sgaypq 236 27 fluids fluid NNS cord-313694-p2sgaypq 236 28 ( ( -LRB- cord-313694-p2sgaypq 236 29 111 111 CD cord-313694-p2sgaypq 236 30 ) ) -RRB- cord-313694-p2sgaypq 236 31 . . . cord-313694-p2sgaypq 237 1 It -PRON- PRP cord-313694-p2sgaypq 237 2 has have VBZ cord-313694-p2sgaypq 237 3 been be VBN cord-313694-p2sgaypq 237 4 suggested suggest VBN cord-313694-p2sgaypq 237 5 that that IN cord-313694-p2sgaypq 237 6 receptors receptor NNS cord-313694-p2sgaypq 237 7 on on IN cord-313694-p2sgaypq 237 8 the the DT cord-313694-p2sgaypq 237 9 Kupffer Kupffer NNP cord-313694-p2sgaypq 237 10 cell cell NN cord-313694-p2sgaypq 237 11 and and CC cord-313694-p2sgaypq 237 12 other other JJ cord-313694-p2sgaypq 237 13 types type NNS cord-313694-p2sgaypq 237 14 of of IN cord-313694-p2sgaypq 237 15 macrophages macrophage NNS cord-313694-p2sgaypq 237 16 may may MD cord-313694-p2sgaypq 237 17 also also RB cord-313694-p2sgaypq 237 18 recognize recognize VB cord-313694-p2sgaypq 237 19 cells cell NNS cord-313694-p2sgaypq 237 20 which which WDT cord-313694-p2sgaypq 237 21 present present VBP cord-313694-p2sgaypq 237 22 the the DT cord-313694-p2sgaypq 237 23 appropriate appropriate JJ cord-313694-p2sgaypq 237 24 configuration configuration NN cord-313694-p2sgaypq 237 25 of of IN cord-313694-p2sgaypq 237 26 carbohydrate carbohydrate NN cord-313694-p2sgaypq 237 27 residues residue NNS cord-313694-p2sgaypq 237 28 ( ( -LRB- cord-313694-p2sgaypq 237 29 110 110 CD cord-313694-p2sgaypq 237 30 ) ) -RRB- cord-313694-p2sgaypq 237 31 . . . cord-313694-p2sgaypq 238 1 Binding bind VBG cord-313694-p2sgaypq 238 2 in in IN cord-313694-p2sgaypq 238 3 these these DT cord-313694-p2sgaypq 238 4 circumstances circumstance NNS cord-313694-p2sgaypq 238 5 may may MD cord-313694-p2sgaypq 238 6 lead lead VB cord-313694-p2sgaypq 238 7 to to IN cord-313694-p2sgaypq 238 8 phagocytosis phagocytosis NN cord-313694-p2sgaypq 238 9 . . . cord-313694-p2sgaypq 239 1 This this DT cord-313694-p2sgaypq 239 2 kind kind NN cord-313694-p2sgaypq 239 3 of of IN cord-313694-p2sgaypq 239 4 binding binding NN cord-313694-p2sgaypq 239 5 has have VBZ cord-313694-p2sgaypq 239 6 been be VBN cord-313694-p2sgaypq 239 7 detected detect VBN cord-313694-p2sgaypq 239 8 in in IN cord-313694-p2sgaypq 239 9 model model NN cord-313694-p2sgaypq 239 10 systems system NNS cord-313694-p2sgaypq 239 11 ( ( -LRB- cord-313694-p2sgaypq 239 12 130 130 CD cord-313694-p2sgaypq 239 13 ) ) -RRB- cord-313694-p2sgaypq 239 14 . . . cord-313694-p2sgaypq 240 1 Several several JJ cord-313694-p2sgaypq 240 2 examples example NNS cord-313694-p2sgaypq 240 3 of of IN cord-313694-p2sgaypq 240 4 a a DT cord-313694-p2sgaypq 240 5 role role NN cord-313694-p2sgaypq 240 6 for for IN cord-313694-p2sgaypq 240 7 protein protein NN cord-313694-p2sgaypq 240 8 glycan glycan NN cord-313694-p2sgaypq 240 9 in in IN cord-313694-p2sgaypq 240 10 other other JJ cord-313694-p2sgaypq 240 11 forms form NNS cord-313694-p2sgaypq 240 12 of of IN cord-313694-p2sgaypq 240 13 intermolecular intermolecular JJ cord-313694-p2sgaypq 240 14 recognition recognition NN cord-313694-p2sgaypq 240 15 have have VBP cord-313694-p2sgaypq 240 16 been be VBN cord-313694-p2sgaypq 240 17 offered offer VBN cord-313694-p2sgaypq 240 18 . . . cord-313694-p2sgaypq 241 1 These these DT cord-313694-p2sgaypq 241 2 include include VBP cord-313694-p2sgaypq 241 3 glycans glycan NNS cord-313694-p2sgaypq 241 4 on on IN cord-313694-p2sgaypq 241 5 the the DT cord-313694-p2sgaypq 241 6 Fc Fc NNP cord-313694-p2sgaypq 241 7 portion portion NN cord-313694-p2sgaypq 241 8 of of IN cord-313694-p2sgaypq 241 9 IgG igg NN cord-313694-p2sgaypq 241 10 being be VBG cord-313694-p2sgaypq 241 11 involved involve VBN cord-313694-p2sgaypq 241 12 in in IN cord-313694-p2sgaypq 241 13 the the DT cord-313694-p2sgaypq 241 14 recognition recognition NN cord-313694-p2sgaypq 241 15 by by IN cord-313694-p2sgaypq 241 16 complement complement JJ cord-313694-p2sgaypq 241 17 proteins protein NNS cord-313694-p2sgaypq 241 18 and and CC cord-313694-p2sgaypq 241 19 cell cell NN cord-313694-p2sgaypq 241 20 surface surface NN cord-313694-p2sgaypq 241 21 receptors receptor NNS cord-313694-p2sgaypq 241 22 ( ( -LRB- cord-313694-p2sgaypq 241 23 70 70 CD cord-313694-p2sgaypq 241 24 , , , cord-313694-p2sgaypq 241 25 129 129 CD cord-313694-p2sgaypq 241 26 ) ) -RRB- cord-313694-p2sgaypq 241 27 , , , cord-313694-p2sgaypq 241 28 glycans glycan NNS cord-313694-p2sgaypq 241 29 of of IN cord-313694-p2sgaypq 241 30 human human JJ cord-313694-p2sgaypq 241 31 chorionic chorionic JJ cord-313694-p2sgaypq 241 32 gonadotropin gonadotropin NN cord-313694-p2sgaypq 241 33 being be VBG cord-313694-p2sgaypq 241 34 involved involve VBN cord-313694-p2sgaypq 241 35 in in IN cord-313694-p2sgaypq 241 36 activation activation NN cord-313694-p2sgaypq 241 37 of of IN cord-313694-p2sgaypq 241 38 its -PRON- PRP$ cord-313694-p2sgaypq 241 39 receptor receptor NN cord-313694-p2sgaypq 241 40 subsequent subsequent JJ cord-313694-p2sgaypq 241 41 to to IN cord-313694-p2sgaypq 241 42 the the DT cord-313694-p2sgaypq 241 43 actual actual JJ cord-313694-p2sgaypq 241 44 binding bind VBG cord-313694-p2sgaypq 241 45 event event NN cord-313694-p2sgaypq 241 46 ( ( -LRB- cord-313694-p2sgaypq 241 47 71 71 CD cord-313694-p2sgaypq 241 48 ) ) -RRB- cord-313694-p2sgaypq 241 49 ( ( -LRB- cord-313694-p2sgaypq 241 50 72 72 CD cord-313694-p2sgaypq 241 51 ) ) -RRB- cord-313694-p2sgaypq 241 52 ( ( -LRB- cord-313694-p2sgaypq 241 53 73 73 CD cord-313694-p2sgaypq 241 54 ) ) -RRB- cord-313694-p2sgaypq 241 55 , , , cord-313694-p2sgaypq 241 56 and and CC cord-313694-p2sgaypq 241 57 interaction interaction NN cord-313694-p2sgaypq 241 58 between between IN cord-313694-p2sgaypq 241 59 anti anti JJ cord-313694-p2sgaypq 241 60 - - JJ cord-313694-p2sgaypq 241 61 thrombin thrombin JJ cord-313694-p2sgaypq 241 62 III III NNP cord-313694-p2sgaypq 241 63 and and CC cord-313694-p2sgaypq 241 64 heparin heparin NN cord-313694-p2sgaypq 241 65 leading lead VBG cord-313694-p2sgaypq 241 66 to to IN cord-313694-p2sgaypq 241 67 activation activation NN cord-313694-p2sgaypq 241 68 of of IN cord-313694-p2sgaypq 241 69 inhibition inhibition NN cord-313694-p2sgaypq 241 70 of of IN cord-313694-p2sgaypq 241 71 thrombin thrombin JJ cord-313694-p2sgaypq 241 72 protease protease NN cord-313694-p2sgaypq 241 73 activity activity NN cord-313694-p2sgaypq 241 74 ( ( -LRB- cord-313694-p2sgaypq 241 75 176 176 CD cord-313694-p2sgaypq 241 76 ) ) -RRB- cord-313694-p2sgaypq 241 77 . . . cord-313694-p2sgaypq 242 1 As as RB cord-313694-p2sgaypq 242 2 early early RB cord-313694-p2sgaypq 242 3 as as IN cord-313694-p2sgaypq 242 4 1945 1945 CD cord-313694-p2sgaypq 242 5 , , , cord-313694-p2sgaypq 242 6 Burnett Burnett NNP cord-313694-p2sgaypq 242 7 ( ( -LRB- cord-313694-p2sgaypq 242 8 119 119 CD cord-313694-p2sgaypq 242 9 ) ) -RRB- cord-313694-p2sgaypq 242 10 and and CC cord-313694-p2sgaypq 242 11 his -PRON- PRP$ cord-313694-p2sgaypq 242 12 colleagues colleague NNS cord-313694-p2sgaypq 242 13 observed observe VBD cord-313694-p2sgaypq 242 14 the the DT cord-313694-p2sgaypq 242 15 importance importance NN cord-313694-p2sgaypq 242 16 of of IN cord-313694-p2sgaypq 242 17 cell cell NN cord-313694-p2sgaypq 242 18 surface surface NN cord-313694-p2sgaypq 242 19 proteinbound proteinbound NNP cord-313694-p2sgaypq 242 20 sialic sialic NN cord-313694-p2sgaypq 242 21 acid acid NN cord-313694-p2sgaypq 242 22 in in IN cord-313694-p2sgaypq 242 23 virus virus NN cord-313694-p2sgaypq 242 24 binding binding NN cord-313694-p2sgaypq 242 25 and and CC cord-313694-p2sgaypq 242 26 infection infection NN cord-313694-p2sgaypq 242 27 . . . cord-313694-p2sgaypq 243 1 This this DT cord-313694-p2sgaypq 243 2 phenomenon phenomenon NN cord-313694-p2sgaypq 243 3 is be VBZ cord-313694-p2sgaypq 243 4 sufficiently sufficiently RB cord-313694-p2sgaypq 243 5 complex complex JJ cord-313694-p2sgaypq 243 6 , , , cord-313694-p2sgaypq 243 7 however however RB cord-313694-p2sgaypq 243 8 , , , cord-313694-p2sgaypq 243 9 that that IN cord-313694-p2sgaypq 243 10 it -PRON- PRP cord-313694-p2sgaypq 243 11 is be VBZ cord-313694-p2sgaypq 243 12 necessary necessary JJ cord-313694-p2sgaypq 243 13 to to TO cord-313694-p2sgaypq 243 14 discuss discuss VB cord-313694-p2sgaypq 243 15 the the DT cord-313694-p2sgaypq 243 16 kinds kind NNS cord-313694-p2sgaypq 243 17 of of IN cord-313694-p2sgaypq 243 18 evidence evidence NN cord-313694-p2sgaypq 243 19 which which WDT cord-313694-p2sgaypq 243 20 are be VBP cord-313694-p2sgaypq 243 21 involved involve VBN cord-313694-p2sgaypq 243 22 in in IN cord-313694-p2sgaypq 243 23 concluding conclude VBG cord-313694-p2sgaypq 243 24 that that IN cord-313694-p2sgaypq 243 25 carbohydrate carbohydrate NN cord-313694-p2sgaypq 243 26 plays play VBZ cord-313694-p2sgaypq 243 27 a a DT cord-313694-p2sgaypq 243 28 direct direct JJ cord-313694-p2sgaypq 243 29 , , , cord-313694-p2sgaypq 243 30 rather rather RB cord-313694-p2sgaypq 243 31 than than IN cord-313694-p2sgaypq 243 32 a a DT cord-313694-p2sgaypq 243 33 regulatory regulatory JJ cord-313694-p2sgaypq 243 34 , , , cord-313694-p2sgaypq 243 35 role role NN cord-313694-p2sgaypq 243 36 in in IN cord-313694-p2sgaypq 243 37 this this DT cord-313694-p2sgaypq 243 38 and and CC cord-313694-p2sgaypq 243 39 other other JJ cord-313694-p2sgaypq 243 40 examples example NNS cord-313694-p2sgaypq 243 41 of of IN cord-313694-p2sgaypq 243 42 adhesion adhesion NN cord-313694-p2sgaypq 243 43 . . . cord-313694-p2sgaypq 244 1 Any any DT cord-313694-p2sgaypq 244 2 demonstration demonstration NN cord-313694-p2sgaypq 244 3 that that WDT cord-313694-p2sgaypq 244 4 carbohydrate carbohydrate NN cord-313694-p2sgaypq 244 5 comprises comprise VBZ cord-313694-p2sgaypq 244 6 part part NN cord-313694-p2sgaypq 244 7 of of IN cord-313694-p2sgaypq 244 8 a a DT cord-313694-p2sgaypq 244 9 physical physical JJ cord-313694-p2sgaypq 244 10 bridge bridge NN cord-313694-p2sgaypq 244 11 in in IN cord-313694-p2sgaypq 244 12 cell cell NN cord-313694-p2sgaypq 244 13 adhesion adhesion NN cord-313694-p2sgaypq 244 14 ( ( -LRB- cord-313694-p2sgaypq 244 15 or or CC cord-313694-p2sgaypq 244 16 any any DT cord-313694-p2sgaypq 244 17 molecular molecular JJ cord-313694-p2sgaypq 244 18 binding binding NN cord-313694-p2sgaypq 244 19 ) ) -RRB- cord-313694-p2sgaypq 244 20 requires require VBZ cord-313694-p2sgaypq 244 21 that that IN cord-313694-p2sgaypq 244 22 four four CD cord-313694-p2sgaypq 244 23 general general JJ cord-313694-p2sgaypq 244 24 criteria criterion NNS cord-313694-p2sgaypq 244 25 be be VB cord-313694-p2sgaypq 244 26 satisfied satisfied JJ cord-313694-p2sgaypq 244 27 : : : cord-313694-p2sgaypq 245 1 1 1 LS cord-313694-p2sgaypq 245 2 ) ) -RRB- cord-313694-p2sgaypq 245 3 removal removal NN cord-313694-p2sgaypq 245 4 or or CC cord-313694-p2sgaypq 245 5 alteration alteration NN cord-313694-p2sgaypq 245 6 of of IN cord-313694-p2sgaypq 245 7 the the DT cord-313694-p2sgaypq 245 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 245 9 diminishes diminish VBZ cord-313694-p2sgaypq 245 10 cell cell NN cord-313694-p2sgaypq 245 11 adhesion adhesion NN cord-313694-p2sgaypq 245 12 ; ; : cord-313694-p2sgaypq 245 13 2 2 LS cord-313694-p2sgaypq 245 14 ) ) -RRB- cord-313694-p2sgaypq 245 15 reconstitution reconstitution NN cord-313694-p2sgaypq 245 16 of of IN cord-313694-p2sgaypq 245 17 the the DT cord-313694-p2sgaypq 245 18 carbohydrate carbohydrate NN cord-313694-p2sgaypq 245 19 either either CC cord-313694-p2sgaypq 245 20 on on IN cord-313694-p2sgaypq 245 21 the the DT cord-313694-p2sgaypq 245 22 cell cell NN cord-313694-p2sgaypq 245 23 or or CC cord-313694-p2sgaypq 245 24 on on IN cord-313694-p2sgaypq 245 25 an an DT cord-313694-p2sgaypq 245 26 artificial artificial JJ cord-313694-p2sgaypq 245 27 surface surface NN cord-313694-p2sgaypq 245 28 re-11 re-11 NNP cord-313694-p2sgaypq 245 29 stores store NNS cord-313694-p2sgaypq 245 30 cell cell NN cord-313694-p2sgaypq 245 31 adhesion adhesion NN cord-313694-p2sgaypq 245 32 ; ; : cord-313694-p2sgaypq 245 33 3 3 LS cord-313694-p2sgaypq 245 34 ) ) -RRB- cord-313694-p2sgaypq 245 35 a a DT cord-313694-p2sgaypq 245 36 specific specific JJ cord-313694-p2sgaypq 245 37 receptor receptor NN cord-313694-p2sgaypq 245 38 for for IN cord-313694-p2sgaypq 245 39 the the DT cord-313694-p2sgaypq 245 40 carbohydrate carbohydrate NN cord-313694-p2sgaypq 245 41 is be VBZ cord-313694-p2sgaypq 245 42 identified identify VBN cord-313694-p2sgaypq 245 43 on on IN cord-313694-p2sgaypq 245 44 the the DT cord-313694-p2sgaypq 245 45 cell cell NN cord-313694-p2sgaypq 245 46 ( ( -LRB- cord-313694-p2sgaypq 245 47 complementary complementary JJ cord-313694-p2sgaypq 245 48 ) ) -RRB- cord-313694-p2sgaypq 245 49 surface surface NN cord-313694-p2sgaypq 245 50 ; ; : cord-313694-p2sgaypq 245 51 4 4 LS cord-313694-p2sgaypq 245 52 ) ) -RRB- cord-313694-p2sgaypq 245 53 inactivation inactivation NN cord-313694-p2sgaypq 245 54 of of IN cord-313694-p2sgaypq 245 55 the the DT cord-313694-p2sgaypq 245 56 receptor receptor NN cord-313694-p2sgaypq 245 57 diminishes diminish VBZ cord-313694-p2sgaypq 245 58 cell cell NN cord-313694-p2sgaypq 245 59 adhesion adhesion NN cord-313694-p2sgaypq 245 60 . . . cord-313694-p2sgaypq 246 1 Satisfaction satisfaction NN cord-313694-p2sgaypq 246 2 of of IN cord-313694-p2sgaypq 246 3 these these DT cord-313694-p2sgaypq 246 4 criteria criterion NNS cord-313694-p2sgaypq 246 5 can can MD cord-313694-p2sgaypq 246 6 be be VB cord-313694-p2sgaypq 246 7 complicated complicate VBN cord-313694-p2sgaypq 246 8 because because IN cord-313694-p2sgaypq 246 9 cells cell NNS cord-313694-p2sgaypq 246 10 appear appear VBP cord-313694-p2sgaypq 246 11 to to TO cord-313694-p2sgaypq 246 12 have have VB cord-313694-p2sgaypq 246 13 multiple multiple JJ cord-313694-p2sgaypq 246 14 adhesion adhesion NN cord-313694-p2sgaypq 246 15 systems system NNS cord-313694-p2sgaypq 246 16 , , , cord-313694-p2sgaypq 246 17 rendering render VBG cord-313694-p2sgaypq 246 18 it -PRON- PRP cord-313694-p2sgaypq 246 19 difficult difficult JJ cord-313694-p2sgaypq 246 20 to to TO cord-313694-p2sgaypq 246 21 assay assay VB cord-313694-p2sgaypq 246 22 one one CD cord-313694-p2sgaypq 246 23 independently independently RB cord-313694-p2sgaypq 246 24 of of IN cord-313694-p2sgaypq 246 25 the the DT cord-313694-p2sgaypq 246 26 others other NNS cord-313694-p2sgaypq 246 27 . . . cord-313694-p2sgaypq 247 1 Removal removal NN cord-313694-p2sgaypq 247 2 of of IN cord-313694-p2sgaypq 247 3 carbohydrate carbohydrate NN cord-313694-p2sgaypq 247 4 can can MD cord-313694-p2sgaypq 247 5 have have VB cord-313694-p2sgaypq 247 6 other other JJ cord-313694-p2sgaypq 247 7 effects effect NNS cord-313694-p2sgaypq 247 8 on on IN cord-313694-p2sgaypq 247 9 cells cell NNS cord-313694-p2sgaypq 247 10 . . . cord-313694-p2sgaypq 248 1 For for IN cord-313694-p2sgaypq 248 2 example example NN cord-313694-p2sgaypq 248 3 , , , cord-313694-p2sgaypq 248 4 cell cell NN cord-313694-p2sgaypq 248 5 viability viability NN cord-313694-p2sgaypq 248 6 can can MD cord-313694-p2sgaypq 248 7 be be VB cord-313694-p2sgaypq 248 8 reduced reduce VBN cord-313694-p2sgaypq 248 9 by by IN cord-313694-p2sgaypq 248 10 drugs drug NNS cord-313694-p2sgaypq 248 11 or or CC cord-313694-p2sgaypq 248 12 mutations mutation NNS cord-313694-p2sgaypq 248 13 affecting affect VBG cord-313694-p2sgaypq 248 14 glycosylation glycosylation NN cord-313694-p2sgaypq 248 15 , , , cord-313694-p2sgaypq 248 16 and and CC cord-313694-p2sgaypq 248 17 transport transport NN cord-313694-p2sgaypq 248 18 of of IN cord-313694-p2sgaypq 248 19 polypeptides polypeptide NNS cord-313694-p2sgaypq 248 20 to to IN cord-313694-p2sgaypq 248 21 the the DT cord-313694-p2sgaypq 248 22 cell cell NN cord-313694-p2sgaypq 248 23 surface surface NN cord-313694-p2sgaypq 248 24 and and CC cord-313694-p2sgaypq 248 25 other other JJ cord-313694-p2sgaypq 248 26 mechanisms mechanism NNS cord-313694-p2sgaypq 248 27 of of IN cord-313694-p2sgaypq 248 28 turnover turnover NN cord-313694-p2sgaypq 248 29 and and CC cord-313694-p2sgaypq 248 30 placement placement NN cord-313694-p2sgaypq 248 31 of of IN cord-313694-p2sgaypq 248 32 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 248 33 can can MD cord-313694-p2sgaypq 248 34 be be VB cord-313694-p2sgaypq 248 35 altered alter VBN cord-313694-p2sgaypq 248 36 . . . cord-313694-p2sgaypq 249 1 Specific specific JJ cord-313694-p2sgaypq 249 2 receptors receptor NNS cord-313694-p2sgaypq 249 3 may may MD cord-313694-p2sgaypq 249 4 be be VB cord-313694-p2sgaypq 249 5 difficult difficult JJ cord-313694-p2sgaypq 249 6 to to TO cord-313694-p2sgaypq 249 7 detect detect VB cord-313694-p2sgaypq 249 8 because because IN cord-313694-p2sgaypq 249 9 individual individual JJ cord-313694-p2sgaypq 249 10 receptor receptor NN cord-313694-p2sgaypq 249 11 - - HYPH cord-313694-p2sgaypq 249 12 ligand ligand NN cord-313694-p2sgaypq 249 13 interactions interaction NNS cord-313694-p2sgaypq 249 14 may may MD cord-313694-p2sgaypq 249 15 have have VB cord-313694-p2sgaypq 249 16 low low JJ cord-313694-p2sgaypq 249 17 affinity affinity NN cord-313694-p2sgaypq 249 18 ( ( -LRB- cord-313694-p2sgaypq 249 19 e.g. e.g. RB cord-313694-p2sgaypq 249 20 , , , cord-313694-p2sgaypq 249 21 126 126 CD cord-313694-p2sgaypq 249 22 ) ) -RRB- cord-313694-p2sgaypq 249 23 . . . cord-313694-p2sgaypq 250 1 A a DT cord-313694-p2sgaypq 250 2 rationale rationale NN cord-313694-p2sgaypq 250 3 for for IN cord-313694-p2sgaypq 250 4 this this DT cord-313694-p2sgaypq 250 5 generalization generalization NN cord-313694-p2sgaypq 250 6 is be VBZ cord-313694-p2sgaypq 250 7 that that IN cord-313694-p2sgaypq 250 8 , , , cord-313694-p2sgaypq 250 9 because because IN cord-313694-p2sgaypq 250 10 of of IN cord-313694-p2sgaypq 250 11 the the DT cord-313694-p2sgaypq 250 12 large large JJ cord-313694-p2sgaypq 250 13 area area NN cord-313694-p2sgaypq 250 14 of of IN cord-313694-p2sgaypq 250 15 cell cell NN cord-313694-p2sgaypq 250 16 surfaces surface NNS cord-313694-p2sgaypq 250 17 , , , cord-313694-p2sgaypq 250 18 cells cell NNS cord-313694-p2sgaypq 250 19 can can MD cord-313694-p2sgaypq 250 20 theoretically theoretically RB cord-313694-p2sgaypq 250 21 interact interact VB cord-313694-p2sgaypq 250 22 with with IN cord-313694-p2sgaypq 250 23 other other JJ cord-313694-p2sgaypq 250 24 surfaces surface NNS cord-313694-p2sgaypq 250 25 using use VBG cord-313694-p2sgaypq 250 26 a a DT cord-313694-p2sgaypq 250 27 large large JJ cord-313694-p2sgaypq 250 28 number number NN cord-313694-p2sgaypq 250 29 of of IN cord-313694-p2sgaypq 250 30 low low JJ cord-313694-p2sgaypq 250 31 affinity affinity NN cord-313694-p2sgaypq 250 32 associations association NNS cord-313694-p2sgaypq 250 33 . . . cord-313694-p2sgaypq 251 1 This this DT cord-313694-p2sgaypq 251 2 may may MD cord-313694-p2sgaypq 251 3 in in IN cord-313694-p2sgaypq 251 4 fact fact NN cord-313694-p2sgaypq 251 5 be be VB cord-313694-p2sgaypq 251 6 desirable desirable JJ cord-313694-p2sgaypq 251 7 for for IN cord-313694-p2sgaypq 251 8 cell cell NN cord-313694-p2sgaypq 251 9 interactions interaction NNS cord-313694-p2sgaypq 251 10 which which WDT cord-313694-p2sgaypq 251 11 would would MD cord-313694-p2sgaypq 251 12 need need VB cord-313694-p2sgaypq 251 13 to to TO cord-313694-p2sgaypq 251 14 be be VB cord-313694-p2sgaypq 251 15 reversible reversible JJ cord-313694-p2sgaypq 251 16 . . . cord-313694-p2sgaypq 252 1 The the DT cord-313694-p2sgaypq 252 2 results result NNS cord-313694-p2sgaypq 252 3 of of IN cord-313694-p2sgaypq 252 4 several several JJ cord-313694-p2sgaypq 252 5 approaches approach NNS cord-313694-p2sgaypq 252 6 where where WRB cord-313694-p2sgaypq 252 7 cell cell NN cord-313694-p2sgaypq 252 8 reassociation reassociation NN cord-313694-p2sgaypq 252 9 has have VBZ cord-313694-p2sgaypq 252 10 been be VBN cord-313694-p2sgaypq 252 11 competed compete VBN cord-313694-p2sgaypq 252 12 with with IN cord-313694-p2sgaypq 252 13 model model NN cord-313694-p2sgaypq 252 14 sugars sugar NNS cord-313694-p2sgaypq 252 15 have have VBP cord-313694-p2sgaypq 252 16 shown show VBN cord-313694-p2sgaypq 252 17 that that IN cord-313694-p2sgaypq 252 18 the the DT cord-313694-p2sgaypq 252 19 competing compete VBG cord-313694-p2sgaypq 252 20 sugars sugar NNS cord-313694-p2sgaypq 252 21 must must MD cord-313694-p2sgaypq 252 22 be be VB cord-313694-p2sgaypq 252 23 crosslinked crosslinke VBN cord-313694-p2sgaypq 252 24 to to TO cord-313694-p2sgaypq 252 25 form form VB cord-313694-p2sgaypq 252 26 multivalent multivalent JJ cord-313694-p2sgaypq 252 27 structures structure NNS cord-313694-p2sgaypq 252 28 in in IN cord-313694-p2sgaypq 252 29 order order NN cord-313694-p2sgaypq 252 30 to to TO cord-313694-p2sgaypq 252 31 be be VB cord-313694-p2sgaypq 252 32 competitive competitive JJ cord-313694-p2sgaypq 252 33 ( ( -LRB- cord-313694-p2sgaypq 252 34 172 172 CD cord-313694-p2sgaypq 252 35 ) ) -RRB- cord-313694-p2sgaypq 252 36 . . . cord-313694-p2sgaypq 253 1 A a DT cord-313694-p2sgaypq 253 2 multivalency multivalency NN cord-313694-p2sgaypq 253 3 requirement requirement NN cord-313694-p2sgaypq 253 4 has have VBZ cord-313694-p2sgaypq 253 5 also also RB cord-313694-p2sgaypq 253 6 been be VBN cord-313694-p2sgaypq 253 7 implicated implicate VBN cord-313694-p2sgaypq 253 8 in in IN cord-313694-p2sgaypq 253 9 the the DT cord-313694-p2sgaypq 253 10 Man-6-PO4 Man-6-PO4 NNP cord-313694-p2sgaypq 253 11 receptor receptor NN cord-313694-p2sgaypq 253 12 system system NN cord-313694-p2sgaypq 253 13 ( ( -LRB- cord-313694-p2sgaypq 253 14 155 155 CD cord-313694-p2sgaypq 253 15 ) ) -RRB- cord-313694-p2sgaypq 253 16 . . . cord-313694-p2sgaypq 254 1 Examination examination NN cord-313694-p2sgaypq 254 2 of of IN cord-313694-p2sgaypq 254 3 cell cell NN cord-313694-p2sgaypq 254 4 - - HYPH cord-313694-p2sgaypq 254 5 ceU ceU VBN cord-313694-p2sgaypq 254 6 and and CC cord-313694-p2sgaypq 254 7 cell cell NN cord-313694-p2sgaypq 254 8 - - HYPH cord-313694-p2sgaypq 254 9 substratum substratum NN cord-313694-p2sgaypq 254 10 adhesion adhesion NN cord-313694-p2sgaypq 254 11 in in IN cord-313694-p2sgaypq 254 12 several several JJ cord-313694-p2sgaypq 254 13 systems system NNS cord-313694-p2sgaypq 254 14 has have VBZ cord-313694-p2sgaypq 254 15 identified identify VBN cord-313694-p2sgaypq 254 16 candidate candidate NN cord-313694-p2sgaypq 254 17 molecules molecule NNS cord-313694-p2sgaypq 254 18 which which WDT cord-313694-p2sgaypq 254 19 participate participate VBP cord-313694-p2sgaypq 254 20 in in IN cord-313694-p2sgaypq 254 21 the the DT cord-313694-p2sgaypq 254 22 formation formation NN cord-313694-p2sgaypq 254 23 of of IN cord-313694-p2sgaypq 254 24 the the DT cord-313694-p2sgaypq 254 25 physical physical JJ cord-313694-p2sgaypq 254 26 bridge bridge NN cord-313694-p2sgaypq 254 27 ( ( -LRB- cord-313694-p2sgaypq 254 28 43 43 CD cord-313694-p2sgaypq 254 29 , , , cord-313694-p2sgaypq 254 30 135 135 CD cord-313694-p2sgaypq 254 31 ) ) -RRB- cord-313694-p2sgaypq 254 32 . . . cord-313694-p2sgaypq 255 1 In in IN cord-313694-p2sgaypq 255 2 some some DT cord-313694-p2sgaypq 255 3 cases case NNS cord-313694-p2sgaypq 255 4 independent independent JJ cord-313694-p2sgaypq 255 5 approaches approach NNS cord-313694-p2sgaypq 255 6 have have VBP cord-313694-p2sgaypq 255 7 converged converge VBN cord-313694-p2sgaypq 255 8 on on IN cord-313694-p2sgaypq 255 9 the the DT cord-313694-p2sgaypq 255 10 same same JJ cord-313694-p2sgaypq 255 11 candidate candidate NN cord-313694-p2sgaypq 255 12 molecules molecule NNS cord-313694-p2sgaypq 255 13 . . . cord-313694-p2sgaypq 256 1 The the DT cord-313694-p2sgaypq 256 2 candidate candidate NN cord-313694-p2sgaypq 256 3 molecules molecule NNS cord-313694-p2sgaypq 256 4 are be VBP cord-313694-p2sgaypq 256 5 usually usually RB cord-313694-p2sgaypq 256 6 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 256 7 and and CC cord-313694-p2sgaypq 256 8 in in IN cord-313694-p2sgaypq 256 9 some some DT cord-313694-p2sgaypq 256 10 cases case NNS cord-313694-p2sgaypq 256 11 the the DT cord-313694-p2sgaypq 256 12 relative relative JJ cord-313694-p2sgaypq 256 13 roles role NNS cord-313694-p2sgaypq 256 14 of of IN cord-313694-p2sgaypq 256 15 carbohydrate carbohydrate NN cord-313694-p2sgaypq 256 16 and and CC cord-313694-p2sgaypq 256 17 protein protein NN cord-313694-p2sgaypq 256 18 have have VBP cord-313694-p2sgaypq 256 19 yet yet RB cord-313694-p2sgaypq 256 20 to to TO cord-313694-p2sgaypq 256 21 be be VB cord-313694-p2sgaypq 256 22 resolved resolve VBN cord-313694-p2sgaypq 256 23 . . . cord-313694-p2sgaypq 257 1 In in IN cord-313694-p2sgaypq 257 2 other other JJ cord-313694-p2sgaypq 257 3 studies study NNS cord-313694-p2sgaypq 257 4 , , , cord-313694-p2sgaypq 257 5 candidates candidate NNS cord-313694-p2sgaypq 257 6 have have VBP cord-313694-p2sgaypq 257 7 not not RB cord-313694-p2sgaypq 257 8 yet yet RB cord-313694-p2sgaypq 257 9 been be VBN cord-313694-p2sgaypq 257 10 identified identify VBN cord-313694-p2sgaypq 257 11 . . . cord-313694-p2sgaypq 258 1 The the DT cord-313694-p2sgaypq 258 2 simplest simple JJS cord-313694-p2sgaypq 258 3 adhesion adhesion NN cord-313694-p2sgaypq 258 4 systems system NNS cord-313694-p2sgaypq 258 5 involve involve VBP cord-313694-p2sgaypq 258 6 parasite parasite NN cord-313694-p2sgaypq 258 7 / / SYM cord-313694-p2sgaypq 258 8 host host NN cord-313694-p2sgaypq 258 9 interaction interaction NN cord-313694-p2sgaypq 258 10 . . . cord-313694-p2sgaypq 259 1 Considerable considerable JJ cord-313694-p2sgaypq 259 2 evidence evidence NN cord-313694-p2sgaypq 259 3 has have VBZ cord-313694-p2sgaypq 259 4 been be VBN cord-313694-p2sgaypq 259 5 adduced adduce VBN cord-313694-p2sgaypq 259 6 that that IN cord-313694-p2sgaypq 259 7 various various JJ cord-313694-p2sgaypq 259 8 parasites parasite NNS cord-313694-p2sgaypq 259 9 such such JJ cord-313694-p2sgaypq 259 10 as as IN cord-313694-p2sgaypq 259 11 viruses virus NNS cord-313694-p2sgaypq 259 12 , , , cord-313694-p2sgaypq 259 13 bacteria bacteria NNS cord-313694-p2sgaypq 259 14 , , , cord-313694-p2sgaypq 259 15 protozoa protozoan NNS cord-313694-p2sgaypq 259 16 , , , cord-313694-p2sgaypq 259 17 etc etc FW cord-313694-p2sgaypq 259 18 . . FW cord-313694-p2sgaypq 259 19 , , , cord-313694-p2sgaypq 259 20 possess possess VBP cord-313694-p2sgaypq 259 21 carbohydrate carbohydrate NN cord-313694-p2sgaypq 259 22 binding bind VBG cord-313694-p2sgaypq 259 23 proteins protein NNS cord-313694-p2sgaypq 259 24 which which WDT cord-313694-p2sgaypq 259 25 can can MD cord-313694-p2sgaypq 259 26 interact interact VB cord-313694-p2sgaypq 259 27 with with IN cord-313694-p2sgaypq 259 28 sugar sugar NN cord-313694-p2sgaypq 259 29 structures structure NNS cord-313694-p2sgaypq 259 30 on on IN cord-313694-p2sgaypq 259 31 the the DT cord-313694-p2sgaypq 259 32 surfaces surface NNS cord-313694-p2sgaypq 259 33 of of IN cord-313694-p2sgaypq 259 34 cells cell NNS cord-313694-p2sgaypq 259 35 with with IN cord-313694-p2sgaypq 259 36 which which WDT cord-313694-p2sgaypq 259 37 the the DT cord-313694-p2sgaypq 259 38 parasites parasite NNS cord-313694-p2sgaypq 259 39 associate associate VBP cord-313694-p2sgaypq 259 40 ( ( -LRB- cord-313694-p2sgaypq 259 41 167 167 CD cord-313694-p2sgaypq 259 42 , , , cord-313694-p2sgaypq 259 43 168 168 CD cord-313694-p2sgaypq 259 44 , , , cord-313694-p2sgaypq 259 45 ( ( -LRB- cord-313694-p2sgaypq 259 46 116 116 CD cord-313694-p2sgaypq 259 47 ) ) -RRB- cord-313694-p2sgaypq 259 48 ( ( -LRB- cord-313694-p2sgaypq 259 49 117 117 CD cord-313694-p2sgaypq 259 50 ) ) -RRB- cord-313694-p2sgaypq 260 1 ( ( -LRB- cord-313694-p2sgaypq 260 2 118 118 CD cord-313694-p2sgaypq 260 3 ) ) -RRB- cord-313694-p2sgaypq 261 1 ( ( -LRB- cord-313694-p2sgaypq 261 2 119 119 CD cord-313694-p2sgaypq 261 3 ) ) -RRB- cord-313694-p2sgaypq 261 4 . . . cord-313694-p2sgaypq 262 1 In in IN cord-313694-p2sgaypq 262 2 some some DT cord-313694-p2sgaypq 262 3 cases case NNS cord-313694-p2sgaypq 262 4 it -PRON- PRP cord-313694-p2sgaypq 262 5 is be VBZ cord-313694-p2sgaypq 262 6 suspected suspect VBN cord-313694-p2sgaypq 262 7 that that IN cord-313694-p2sgaypq 262 8 this this DT cord-313694-p2sgaypq 262 9 sugar sugar NN cord-313694-p2sgaypq 262 10 is be VBZ cord-313694-p2sgaypq 262 11 associated associate VBN cord-313694-p2sgaypq 262 12 with with IN cord-313694-p2sgaypq 262 13 glycolipid glycolipid NNP cord-313694-p2sgaypq 262 14 but but CC cord-313694-p2sgaypq 262 15 in in IN cord-313694-p2sgaypq 262 16 other other JJ cord-313694-p2sgaypq 262 17 cases case NNS cord-313694-p2sgaypq 262 18 Man Man NNP cord-313694-p2sgaypq 262 19 is be VBZ cord-313694-p2sgaypq 262 20 believed believe VBN cord-313694-p2sgaypq 262 21 to to TO cord-313694-p2sgaypq 262 22 be be VB cord-313694-p2sgaypq 262 23 involved involve VBN cord-313694-p2sgaypq 262 24 on on IN cord-313694-p2sgaypq 262 25 the the DT cord-313694-p2sgaypq 262 26 basis basis NN cord-313694-p2sgaypq 262 27 of of IN cord-313694-p2sgaypq 262 28 competition competition NN cord-313694-p2sgaypq 262 29 studies study NNS cord-313694-p2sgaypq 262 30 ( ( -LRB- cord-313694-p2sgaypq 262 31 e.g. e.g. RB cord-313694-p2sgaypq 262 32 , , , cord-313694-p2sgaypq 262 33 114 114 CD cord-313694-p2sgaypq 262 34 ) ) -RRB- cord-313694-p2sgaypq 262 35 . . . cord-313694-p2sgaypq 263 1 This this DT cord-313694-p2sgaypq 263 2 would would MD cord-313694-p2sgaypq 263 3 imply imply VB cord-313694-p2sgaypq 263 4 the the DT cord-313694-p2sgaypq 263 5 involvement involvement NN cord-313694-p2sgaypq 263 6 of of IN cord-313694-p2sgaypq 263 7 glycoprotein glycoprotein NN cord-313694-p2sgaypq 263 8 because because IN cord-313694-p2sgaypq 263 9 this this DT cord-313694-p2sgaypq 263 10 sugar sugar NN cord-313694-p2sgaypq 263 11 is be VBZ cord-313694-p2sgaypq 263 12 rare rare JJ cord-313694-p2sgaypq 263 13 in in IN cord-313694-p2sgaypq 263 14 glycolipid glycolipid NNP cord-313694-p2sgaypq 263 15 . . . cord-313694-p2sgaypq 264 1 The the DT cord-313694-p2sgaypq 264 2 use use NN cord-313694-p2sgaypq 264 3 of of IN cord-313694-p2sgaypq 264 4 carbohydrate carbohydrate NN cord-313694-p2sgaypq 264 5 as as IN cord-313694-p2sgaypq 264 6 attachment attachment NN cord-313694-p2sgaypq 264 7 points point NNS cord-313694-p2sgaypq 264 8 on on IN cord-313694-p2sgaypq 264 9 cells cell NNS cord-313694-p2sgaypq 264 10 presumably presumably RB cord-313694-p2sgaypq 264 11 reflects reflect VBZ cord-313694-p2sgaypq 264 12 the the DT cord-313694-p2sgaypq 264 13 stability stability NN cord-313694-p2sgaypq 264 14 of of IN cord-313694-p2sgaypq 264 15 these these DT cord-313694-p2sgaypq 264 16 structures structure NNS cord-313694-p2sgaypq 264 17 on on IN cord-313694-p2sgaypq 264 18 cell cell NN cord-313694-p2sgaypq 264 19 surfaces surface NNS cord-313694-p2sgaypq 264 20 and and CC cord-313694-p2sgaypq 264 21 their -PRON- PRP$ cord-313694-p2sgaypq 264 22 specific specific JJ cord-313694-p2sgaypq 264 23 associations association NNS cord-313694-p2sgaypq 264 24 with with IN cord-313694-p2sgaypq 264 25 target target NN cord-313694-p2sgaypq 264 26 cells cell NNS cord-313694-p2sgaypq 264 27 suitable suitable JJ cord-313694-p2sgaypq 264 28 for for IN cord-313694-p2sgaypq 264 29 the the DT cord-313694-p2sgaypq 264 30 parasite parasite NN cord-313694-p2sgaypq 264 31 . . . cord-313694-p2sgaypq 265 1 These these DT cord-313694-p2sgaypq 265 2 would would MD cord-313694-p2sgaypq 265 3 of of IN cord-313694-p2sgaypq 265 4 course course NN cord-313694-p2sgaypq 265 5 be be VB cord-313694-p2sgaypq 265 6 useful useful JJ cord-313694-p2sgaypq 265 7 features feature NNS cord-313694-p2sgaypq 265 8 for for IN cord-313694-p2sgaypq 265 9 any any DT cord-313694-p2sgaypq 265 10 mechanism mechanism NN cord-313694-p2sgaypq 265 11 of of IN cord-313694-p2sgaypq 265 12 specific specific JJ cord-313694-p2sgaypq 265 13 cell cell NN cord-313694-p2sgaypq 265 14 - - HYPH cord-313694-p2sgaypq 265 15 cell cell NN cord-313694-p2sgaypq 265 16 interaction interaction NN cord-313694-p2sgaypq 265 17 . . . cord-313694-p2sgaypq 266 1 Species species NN cord-313694-p2sgaypq 266 2 - - HYPH cord-313694-p2sgaypq 266 3 specific specific JJ cord-313694-p2sgaypq 266 4 cell cell NN cord-313694-p2sgaypq 266 5 - - HYPH cord-313694-p2sgaypq 266 6 cell cell NN cord-313694-p2sgaypq 266 7 adhesion adhesion NN cord-313694-p2sgaypq 266 8 ( ( -LRB- cord-313694-p2sgaypq 266 9 the the DT cord-313694-p2sgaypq 266 10 so so RB cord-313694-p2sgaypq 266 11 - - HYPH cord-313694-p2sgaypq 266 12 called call VBN cord-313694-p2sgaypq 266 13 secondary secondary JJ cord-313694-p2sgaypq 266 14 type type NN cord-313694-p2sgaypq 266 15 ) ) -RRB- cord-313694-p2sgaypq 266 16 in in IN cord-313694-p2sgaypq 266 17 the the DT cord-313694-p2sgaypq 266 18 phylogenetically phylogenetically RB cord-313694-p2sgaypq 266 19 - - HYPH cord-313694-p2sgaypq 266 20 primitive primitive JJ cord-313694-p2sgaypq 266 21 marine marine JJ cord-313694-p2sgaypq 266 22 sponge sponge NN cord-313694-p2sgaypq 266 23 is be VBZ cord-313694-p2sgaypq 266 24 suspected suspect VBN cord-313694-p2sgaypq 266 25 to to TO cord-313694-p2sgaypq 266 26 involve involve VB cord-313694-p2sgaypq 266 27 carbohydrate carbohydrate NN cord-313694-p2sgaypq 266 28 ligands ligand NNS cord-313694-p2sgaypq 266 29 ( ( -LRB- cord-313694-p2sgaypq 266 30 133 133 CD cord-313694-p2sgaypq 266 31 ) ) -RRB- cord-313694-p2sgaypq 266 32 . . . cord-313694-p2sgaypq 267 1 Ca ca VB cord-313694-p2sgaypq 267 2 - - HYPH cord-313694-p2sgaypq 267 3 free free JJ cord-313694-p2sgaypq 267 4 sea sea NN cord-313694-p2sgaypq 267 5 water water NN cord-313694-p2sgaypq 267 6 elutes elutes NNP cord-313694-p2sgaypq 267 7 a a DT cord-313694-p2sgaypq 267 8 fraction fraction NN cord-313694-p2sgaypq 267 9 from from IN cord-313694-p2sgaypq 267 10 cells cell NNS cord-313694-p2sgaypq 267 11 of of IN cord-313694-p2sgaypq 267 12 Microcionaprolifera Microcionaprolifera NNP cord-313694-p2sgaypq 267 13 which which WDT cord-313694-p2sgaypq 267 14 is be VBZ cord-313694-p2sgaypq 267 15 required require VBN cord-313694-p2sgaypq 267 16 for for IN cord-313694-p2sgaypq 267 17 their -PRON- PRP$ cord-313694-p2sgaypq 267 18 reaggregation reaggregation NN cord-313694-p2sgaypq 267 19 . . . cord-313694-p2sgaypq 268 1 This this DT cord-313694-p2sgaypq 268 2 fraction fraction NN cord-313694-p2sgaypq 268 3 is be VBZ cord-313694-p2sgaypq 268 4 the the DT cord-313694-p2sgaypq 268 5 source source NN cord-313694-p2sgaypq 268 6 of of IN cord-313694-p2sgaypq 268 7 a a DT cord-313694-p2sgaypq 268 8 purified purify VBN cord-313694-p2sgaypq 268 9 proteoglycan proteoglycan NN cord-313694-p2sgaypq 268 10 which which WDT cord-313694-p2sgaypq 268 11 is be VBZ cord-313694-p2sgaypq 268 12 referred refer VBN cord-313694-p2sgaypq 268 13 to to IN cord-313694-p2sgaypq 268 14 as as IN cord-313694-p2sgaypq 268 15 aggregation aggregation NN cord-313694-p2sgaypq 268 16 factor factor NN cord-313694-p2sgaypq 268 17 . . . cord-313694-p2sgaypq 269 1 Hypotonic Hypotonic NNP cord-313694-p2sgaypq 269 2 shock shock NN cord-313694-p2sgaypq 269 3 elutes elute VBZ cord-313694-p2sgaypq 269 4 another another DT cord-313694-p2sgaypq 269 5 molecular molecular JJ cord-313694-p2sgaypq 269 6 species species NN cord-313694-p2sgaypq 269 7 ( ( -LRB- cord-313694-p2sgaypq 269 8 the the DT cord-313694-p2sgaypq 269 9 so so RB cord-313694-p2sgaypq 269 10 - - HYPH cord-313694-p2sgaypq 269 11 caUed caUed NNP cord-313694-p2sgaypq 269 12 baseplate baseplate NN cord-313694-p2sgaypq 269 13 or or CC cord-313694-p2sgaypq 269 14 aggregation aggregation NN cord-313694-p2sgaypq 269 15 factor factor NN cord-313694-p2sgaypq 269 16 receptor receptor NN cord-313694-p2sgaypq 269 17 ) ) -RRB- cord-313694-p2sgaypq 269 18 which which WDT cord-313694-p2sgaypq 269 19 is be VBZ cord-313694-p2sgaypq 269 20 also also RB cord-313694-p2sgaypq 269 21 required require VBN cord-313694-p2sgaypq 269 22 for for IN cord-313694-p2sgaypq 269 23 reaggregation reaggregation NN cord-313694-p2sgaypq 269 24 and and CC cord-313694-p2sgaypq 269 25 may may MD cord-313694-p2sgaypq 269 26 recognize recognize VB cord-313694-p2sgaypq 269 27 the the DT cord-313694-p2sgaypq 269 28 proteoglycan proteoglycan NN cord-313694-p2sgaypq 269 29 by by IN cord-313694-p2sgaypq 269 30 a a DT cord-313694-p2sgaypq 269 31 mechanism mechanism NN cord-313694-p2sgaypq 269 32 involving involve VBG cord-313694-p2sgaypq 269 33 glucuronic glucuronic NNP cord-313694-p2sgaypq 269 34 acid acid NN cord-313694-p2sgaypq 269 35 on on IN cord-313694-p2sgaypq 269 36 the the DT cord-313694-p2sgaypq 269 37 proteoglycan proteoglycan NN cord-313694-p2sgaypq 269 38 . . . cord-313694-p2sgaypq 270 1 These these DT cord-313694-p2sgaypq 270 2 preliminary preliminary JJ cord-313694-p2sgaypq 270 3 findings finding NNS cord-313694-p2sgaypq 270 4 were be VBD cord-313694-p2sgaypq 270 5 ascertained ascertain VBN cord-313694-p2sgaypq 270 6 by by IN cord-313694-p2sgaypq 270 7 competition competition NN cord-313694-p2sgaypq 270 8 studies study NNS cord-313694-p2sgaypq 270 9 with with IN cord-313694-p2sgaypq 270 10 model model NN cord-313694-p2sgaypq 270 11 sugars sugar NNS cord-313694-p2sgaypq 270 12 and and CC cord-313694-p2sgaypq 270 13 enzymatic enzymatic JJ cord-313694-p2sgaypq 270 14 treatments treatment NNS cord-313694-p2sgaypq 270 15 , , , cord-313694-p2sgaypq 270 16 and and CC cord-313694-p2sgaypq 270 17 it -PRON- PRP cord-313694-p2sgaypq 270 18 will will MD cord-313694-p2sgaypq 270 19 be be VB cord-313694-p2sgaypq 270 20 interesting interesting JJ cord-313694-p2sgaypq 270 21 to to TO cord-313694-p2sgaypq 270 22 confirm confirm VB cord-313694-p2sgaypq 270 23 these these DT cord-313694-p2sgaypq 270 24 findings finding NNS cord-313694-p2sgaypq 270 25 using use VBG cord-313694-p2sgaypq 270 26 purified purify VBN cord-313694-p2sgaypq 270 27 molecules molecule NNS cord-313694-p2sgaypq 270 28 ( ( -LRB- cord-313694-p2sgaypq 270 29 179 179 CD cord-313694-p2sgaypq 270 30 ) ) -RRB- cord-313694-p2sgaypq 270 31 . . . cord-313694-p2sgaypq 271 1 Results result NNS cord-313694-p2sgaypq 271 2 of of IN cord-313694-p2sgaypq 271 3 comparable comparable JJ cord-313694-p2sgaypq 271 4 studies study NNS cord-313694-p2sgaypq 271 5 in in IN cord-313694-p2sgaypq 271 6 another another DT cord-313694-p2sgaypq 271 7 marine marine JJ cord-313694-p2sgaypq 271 8 sponge sponge NN cord-313694-p2sgaypq 271 9 , , , cord-313694-p2sgaypq 271 10 Geodia Geodia NNP cord-313694-p2sgaypq 271 11 cydonium cydonium NNP cord-313694-p2sgaypq 271 12 , , , cord-313694-p2sgaypq 271 13 are be VBP cord-313694-p2sgaypq 271 14 even even RB cord-313694-p2sgaypq 271 15 more more RBR cord-313694-p2sgaypq 271 16 intriguing intriguing JJ cord-313694-p2sgaypq 271 17 ( ( -LRB- cord-313694-p2sgaypq 271 18 133 133 CD cord-313694-p2sgaypq 271 19 ) ) -RRB- cord-313694-p2sgaypq 271 20 . . . cord-313694-p2sgaypq 272 1 Bound bind VBN cord-313694-p2sgaypq 272 2 t3-glucuronic t3-glucuronic NNP cord-313694-p2sgaypq 272 3 acid acid NN cord-313694-p2sgaypq 272 4 is be VBZ cord-313694-p2sgaypq 272 5 also also RB cord-313694-p2sgaypq 272 6 believed believe VBN cord-313694-p2sgaypq 272 7 to to TO cord-313694-p2sgaypq 272 8 be be VB cord-313694-p2sgaypq 272 9 important important JJ cord-313694-p2sgaypq 272 10 in in IN cord-313694-p2sgaypq 272 11 aggregation aggregation NN cord-313694-p2sgaypq 272 12 factor factor NN cord-313694-p2sgaypq 272 13 / / SYM cord-313694-p2sgaypq 272 14 baseplate baseplate NN cord-313694-p2sgaypq 272 15 recognition recognition NN cord-313694-p2sgaypq 272 16 but but CC cord-313694-p2sgaypq 272 17 its -PRON- PRP$ cord-313694-p2sgaypq 272 18 position position NN cord-313694-p2sgaypq 272 19 is be VBZ cord-313694-p2sgaypq 272 20 reversed reverse VBN cord-313694-p2sgaypq 272 21 so so IN cord-313694-p2sgaypq 272 22 that that IN cord-313694-p2sgaypq 272 23 the the DT cord-313694-p2sgaypq 272 24 key key JJ cord-313694-p2sgaypq 272 25 sugar sugar NN cord-313694-p2sgaypq 272 26 is be VBZ cord-313694-p2sgaypq 272 27 on on IN cord-313694-p2sgaypq 272 28 the the DT cord-313694-p2sgaypq 272 29 baseplate baseplate NN cord-313694-p2sgaypq 272 30 glycoprotein glycoprotein NN cord-313694-p2sgaypq 272 31 . . . cord-313694-p2sgaypq 273 1 Beta beta NN cord-313694-p2sgaypq 273 2 - - HYPH cord-313694-p2sgaypq 273 3 glucuronidase glucuronidase NN cord-313694-p2sgaypq 273 4 and and CC cord-313694-p2sgaypq 273 5 j3-glucuronyltransferase j3-glucuronyltransferase NNP cord-313694-p2sgaypq 273 6 can can MD cord-313694-p2sgaypq 273 7 be be VB cord-313694-p2sgaypq 273 8 eluted elute VBN cord-313694-p2sgaypq 273 9 from from IN cord-313694-p2sgaypq 273 10 extracellular extracellular JJ cord-313694-p2sgaypq 273 11 material material NN cord-313694-p2sgaypq 273 12 suggesting suggest VBG cord-313694-p2sgaypq 273 13 a a DT cord-313694-p2sgaypq 273 14 mechanism mechanism NN cord-313694-p2sgaypq 273 15 for for IN cord-313694-p2sgaypq 273 16 the the DT cord-313694-p2sgaypq 273 17 dynamic dynamic JJ cord-313694-p2sgaypq 273 18 regulation regulation NN cord-313694-p2sgaypq 273 19 of of IN cord-313694-p2sgaypq 273 20 cell cell NN cord-313694-p2sgaypq 273 21 recognition recognition NN cord-313694-p2sgaypq 273 22 . . . cord-313694-p2sgaypq 274 1 An an DT cord-313694-p2sgaypq 274 2 investigation investigation NN cord-313694-p2sgaypq 274 3 into into IN cord-313694-p2sgaypq 274 4 the the DT cord-313694-p2sgaypq 274 5 tissue tissue NN cord-313694-p2sgaypq 274 6 specificity specificity NN cord-313694-p2sgaypq 274 7 of of IN cord-313694-p2sgaypq 274 8 cell cell NN cord-313694-p2sgaypq 274 9 recognition recognition NN cord-313694-p2sgaypq 274 10 showed show VBD cord-313694-p2sgaypq 274 11 that that IN cord-313694-p2sgaypq 274 12 ~-galactosidase ~-galactosidase NFP cord-313694-p2sgaypq 274 13 treatment treatment NN cord-313694-p2sgaypq 274 14 of of IN cord-313694-p2sgaypq 274 15 nonaggregating nonaggregating NN cord-313694-p2sgaypq 274 16 cells cell NNS cord-313694-p2sgaypq 274 17 permitted permit VBD cord-313694-p2sgaypq 274 18 their -PRON- PRP$ cord-313694-p2sgaypq 274 19 aggregation aggregation NN cord-313694-p2sgaypq 274 20 in in IN cord-313694-p2sgaypq 274 21 the the DT cord-313694-p2sgaypq 274 22 presence presence NN cord-313694-p2sgaypq 274 23 of of IN cord-313694-p2sgaypq 274 24 aggregation aggregation NN cord-313694-p2sgaypq 274 25 factor factor NN cord-313694-p2sgaypq 274 26 . . . cord-313694-p2sgaypq 275 1 A a DT cord-313694-p2sgaypq 275 2 protein protein NN cord-313694-p2sgaypq 275 3 was be VBD cord-313694-p2sgaypq 275 4 then then RB cord-313694-p2sgaypq 275 5 isolated isolate VBN cord-313694-p2sgaypq 275 6 which which WDT cord-313694-p2sgaypq 275 7 could could MD cord-313694-p2sgaypq 275 8 inhibit inhibit VB cord-313694-p2sgaypq 275 9 aggregation aggregation NN cord-313694-p2sgaypq 275 10 of of IN cord-313694-p2sgaypq 275 11 aggregation aggregation NN cord-313694-p2sgaypq 275 12 - - HYPH cord-313694-p2sgaypq 275 13 competent competent JJ cord-313694-p2sgaypq 275 14 cells cell NNS cord-313694-p2sgaypq 275 15 in in IN cord-313694-p2sgaypq 275 16 a a DT cord-313694-p2sgaypq 275 17 fl fl JJ cord-313694-p2sgaypq 275 18 - - HYPH cord-313694-p2sgaypq 275 19 galactosidase galactosidase NN cord-313694-p2sgaypq 275 20 sensitive sensitive JJ cord-313694-p2sgaypq 275 21 fashion fashion NN cord-313694-p2sgaypq 275 22 . . . cord-313694-p2sgaypq 276 1 Finally finally RB cord-313694-p2sgaypq 276 2 , , , cord-313694-p2sgaypq 276 3 a a DT cord-313694-p2sgaypq 276 4 t3-galactoside t3-galactoside NN cord-313694-p2sgaypq 276 5 binding bind VBG cord-313694-p2sgaypq 276 6 protein protein NN cord-313694-p2sgaypq 276 7 was be VBD cord-313694-p2sgaypq 276 8 isolated isolate VBN cord-313694-p2sgaypq 276 9 from from IN cord-313694-p2sgaypq 276 10 extracellular extracellular JJ cord-313694-p2sgaypq 276 11 material material NN cord-313694-p2sgaypq 276 12 which which WDT cord-313694-p2sgaypq 276 13 rendered render VBD cord-313694-p2sgaypq 276 14 an an DT cord-313694-p2sgaypq 276 15 effect effect NN cord-313694-p2sgaypq 276 16 similar similar JJ cord-313694-p2sgaypq 276 17 to to IN cord-313694-p2sgaypq 276 18 that that DT cord-313694-p2sgaypq 276 19 of of IN cord-313694-p2sgaypq 276 20 the the DT cord-313694-p2sgaypq 276 21 glycosidase glycosidase NN cord-313694-p2sgaypq 276 22 . . . cord-313694-p2sgaypq 277 1 Though though IN cord-313694-p2sgaypq 277 2 the the DT cord-313694-p2sgaypq 277 3 significance significance NN cord-313694-p2sgaypq 277 4 of of IN cord-313694-p2sgaypq 277 5 these these DT cord-313694-p2sgaypq 277 6 observations observation NNS cord-313694-p2sgaypq 277 7 is be VBZ cord-313694-p2sgaypq 277 8 as as RB cord-313694-p2sgaypq 277 9 yet yet RB cord-313694-p2sgaypq 277 10 unclear unclear JJ cord-313694-p2sgaypq 277 11 , , , cord-313694-p2sgaypq 277 12 it -PRON- PRP cord-313694-p2sgaypq 277 13 has have VBZ cord-313694-p2sgaypq 277 14 been be VBN cord-313694-p2sgaypq 277 15 suggested suggest VBN cord-313694-p2sgaypq 277 16 that that IN cord-313694-p2sgaypq 277 17 carbohydrate carbohydrate NN cord-313694-p2sgaypq 277 18 structures structure NNS cord-313694-p2sgaypq 277 19 may may MD cord-313694-p2sgaypq 277 20 underlie underlie VB cord-313694-p2sgaypq 277 21 specific specific JJ cord-313694-p2sgaypq 277 22 mechanisms mechanism NNS cord-313694-p2sgaypq 277 23 of of IN cord-313694-p2sgaypq 277 24 cell cell NN cord-313694-p2sgaypq 277 25 recognition recognition NN cord-313694-p2sgaypq 277 26 in in IN cord-313694-p2sgaypq 277 27 multiple multiple JJ cord-313694-p2sgaypq 277 28 ways way NNS cord-313694-p2sgaypq 277 29 in in IN cord-313694-p2sgaypq 277 30 these these DT cord-313694-p2sgaypq 277 31 species specie NNS cord-313694-p2sgaypq 277 32 . . . cord-313694-p2sgaypq 278 1 Cell cell NN cord-313694-p2sgaypq 278 2 - - HYPH cord-313694-p2sgaypq 278 3 substratum substratum NN cord-313694-p2sgaypq 278 4 adhesion adhesion NN cord-313694-p2sgaypq 278 5 in in IN cord-313694-p2sgaypq 278 6 another another DT cord-313694-p2sgaypq 278 7 primitive primitive JJ cord-313694-p2sgaypq 278 8 multicellular multicellular JJ cord-313694-p2sgaypq 278 9 system system NN cord-313694-p2sgaypq 278 10 , , , cord-313694-p2sgaypq 278 11 aggregating aggregate VBG cord-313694-p2sgaypq 278 12 cellular cellular JJ cord-313694-p2sgaypq 278 13 slime slime NN cord-313694-p2sgaypq 278 14 mold mold NN cord-313694-p2sgaypq 278 15 cells cell NNS cord-313694-p2sgaypq 278 16 , , , cord-313694-p2sgaypq 278 17 appears appear VBZ cord-313694-p2sgaypq 278 18 to to TO cord-313694-p2sgaypq 278 19 involve involve VB cord-313694-p2sgaypq 278 20 a a DT cord-313694-p2sgaypq 278 21 multivalent multivalent JJ cord-313694-p2sgaypq 278 22 carbohydrate carbohydrate NN cord-313694-p2sgaypq 278 23 binding bind VBG cord-313694-p2sgaypq 278 24 protein protein NN cord-313694-p2sgaypq 278 25 termed term VBN cord-313694-p2sgaypq 278 26 discoidin discoidin NNP cord-313694-p2sgaypq 278 27 I. I. NNP cord-313694-p2sgaypq 279 1 The the DT cord-313694-p2sgaypq 279 2 involvement involvement NN cord-313694-p2sgaypq 279 3 of of IN cord-313694-p2sgaypq 279 4 discoidin discoidin NNS cord-313694-p2sgaypq 279 5 I -PRON- PRP cord-313694-p2sgaypq 279 6 was be VBD cord-313694-p2sgaypq 279 7 initially initially RB cord-313694-p2sgaypq 279 8 recognized recognize VBN cord-313694-p2sgaypq 279 9 based base VBN cord-313694-p2sgaypq 279 10 on on IN cord-313694-p2sgaypq 279 11 sequence sequence NN cord-313694-p2sgaypq 279 12 homology homology NN cord-313694-p2sgaypq 279 13 between between IN cord-313694-p2sgaypq 279 14 this this DT cord-313694-p2sgaypq 279 15 protein protein NN cord-313694-p2sgaypq 279 16 and and CC cord-313694-p2sgaypq 279 17 an an DT cord-313694-p2sgaypq 279 18 oligopeptide oligopeptide JJ cord-313694-p2sgaypq 279 19 sequence sequence NN cord-313694-p2sgaypq 279 20 of of IN cord-313694-p2sgaypq 279 21 vertebrate vertebrate JJ cord-313694-p2sgaypq 279 22 fibronectin fibronectin NN cord-313694-p2sgaypq 279 23 which which WDT cord-313694-p2sgaypq 279 24 has have VBZ cord-313694-p2sgaypq 279 25 been be VBN cord-313694-p2sgaypq 279 26 shown show VBN cord-313694-p2sgaypq 279 27 to to TO cord-313694-p2sgaypq 279 28 contain contain VB cord-313694-p2sgaypq 279 29 its -PRON- PRP$ cord-313694-p2sgaypq 279 30 cell cell NN cord-313694-p2sgaypq 279 31 binding binding NN cord-313694-p2sgaypq 279 32 site site NN cord-313694-p2sgaypq 279 33 . . . cord-313694-p2sgaypq 280 1 This this DT cord-313694-p2sgaypq 280 2 oligopeptide oligopeptide NN cord-313694-p2sgaypq 280 3 , , , cord-313694-p2sgaypq 280 4 which which WDT cord-313694-p2sgaypq 280 5 blocks block VBZ cord-313694-p2sgaypq 280 6 fibronectin fibronectin NN cord-313694-p2sgaypq 280 7 binding bind VBG cord-313694-p2sgaypq 280 8 to to IN cord-313694-p2sgaypq 280 9 cells cell NNS cord-313694-p2sgaypq 280 10 , , , cord-313694-p2sgaypq 280 11 also also RB cord-313694-p2sgaypq 280 12 affects affect VBZ cord-313694-p2sgaypq 280 13 association association NN cord-313694-p2sgaypq 280 14 of of IN cord-313694-p2sgaypq 280 15 Dictyosteliurn Dictyosteliurn NNP cord-313694-p2sgaypq 280 16 cells cell NNS cord-313694-p2sgaypq 280 17 with with IN cord-313694-p2sgaypq 280 18 their -PRON- PRP$ cord-313694-p2sgaypq 280 19 substrata substrata NNS cord-313694-p2sgaypq 280 20 ( ( -LRB- cord-313694-p2sgaypq 280 21 148 148 CD cord-313694-p2sgaypq 280 22 ) ) -RRB- cord-313694-p2sgaypq 280 23 . . . cord-313694-p2sgaypq 281 1 The the DT cord-313694-p2sgaypq 281 2 ceils ceil NNS cord-313694-p2sgaypq 281 3 become become VBP cord-313694-p2sgaypq 281 4 incapable incapable JJ cord-313694-p2sgaypq 281 5 of of IN cord-313694-p2sgaypq 281 6 migrating migrate VBG cord-313694-p2sgaypq 281 7 properly properly RB cord-313694-p2sgaypq 281 8 on on IN cord-313694-p2sgaypq 281 9 a a DT cord-313694-p2sgaypq 281 10 surface surface NN cord-313694-p2sgaypq 281 11 . . . cord-313694-p2sgaypq 282 1 The the DT cord-313694-p2sgaypq 282 2 effect effect NN cord-313694-p2sgaypq 282 3 can can MD cord-313694-p2sgaypq 282 4 be be VB cord-313694-p2sgaypq 282 5 mimicked mimic VBN cord-313694-p2sgaypq 282 6 by by IN cord-313694-p2sgaypq 282 7 antidiscoidin antidiscoidin NNP cord-313694-p2sgaypq 282 8 I. I. NNP cord-313694-p2sgaypq 283 1 The the DT cord-313694-p2sgaypq 283 2 effect effect NN cord-313694-p2sgaypq 283 3 is be VBZ cord-313694-p2sgaypq 283 4 also also RB cord-313694-p2sgaypq 283 5 replicated replicate VBN cord-313694-p2sgaypq 283 6 if if IN cord-313694-p2sgaypq 283 7 the the DT cord-313694-p2sgaypq 283 8 cells cell NNS cord-313694-p2sgaypq 283 9 are be VBP cord-313694-p2sgaypq 283 10 transformed transform VBN cord-313694-p2sgaypq 283 11 with with IN cord-313694-p2sgaypq 283 12 a a DT cord-313694-p2sgaypq 283 13 gene gene NN cord-313694-p2sgaypq 283 14 which which WDT cord-313694-p2sgaypq 283 15 encodes encode VBZ cord-313694-p2sgaypq 283 16 an an DT cord-313694-p2sgaypq 283 17 mRNA mrna NN cord-313694-p2sgaypq 283 18 which which WDT cord-313694-p2sgaypq 283 19 hybridizes hybridize VBZ cord-313694-p2sgaypq 283 20 with with IN cord-313694-p2sgaypq 283 21 authentic authentic JJ cord-313694-p2sgaypq 283 22 discoidin discoidin NNS cord-313694-p2sgaypq 284 1 I -PRON- PRP cord-313694-p2sgaypq 284 2 mRNA mrna NN cord-313694-p2sgaypq 285 1 and and CC cord-313694-p2sgaypq 285 2 blocks block VBZ cord-313694-p2sgaypq 285 3 its -PRON- PRP$ cord-313694-p2sgaypq 285 4 translation translation NN cord-313694-p2sgaypq 285 5 ( ( -LRB- cord-313694-p2sgaypq 285 6 149 149 CD cord-313694-p2sgaypq 285 7 ) ) -RRB- cord-313694-p2sgaypq 285 8 . . . cord-313694-p2sgaypq 286 1 The the DT cord-313694-p2sgaypq 286 2 evidence evidence NN cord-313694-p2sgaypq 286 3 is be VBZ cord-313694-p2sgaypq 286 4 very very RB cord-313694-p2sgaypq 286 5 strong strong JJ cord-313694-p2sgaypq 286 6 that that IN cord-313694-p2sgaypq 286 7 this this DT cord-313694-p2sgaypq 286 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 286 9 binding bind VBG cord-313694-p2sgaypq 286 10 protein protein NN cord-313694-p2sgaypq 286 11 is be VBZ cord-313694-p2sgaypq 286 12 involved involve VBN cord-313694-p2sgaypq 286 13 in in IN cord-313694-p2sgaypq 286 14 cell cell NN cord-313694-p2sgaypq 286 15 - - HYPH cord-313694-p2sgaypq 286 16 substratum substratum NN cord-313694-p2sgaypq 286 17 association association NN cord-313694-p2sgaypq 286 18 . . . cord-313694-p2sgaypq 287 1 What what WP cord-313694-p2sgaypq 287 2 is be VBZ cord-313694-p2sgaypq 287 3 unclear unclear JJ cord-313694-p2sgaypq 287 4 , , , cord-313694-p2sgaypq 287 5 however however RB cord-313694-p2sgaypq 287 6 , , , cord-313694-p2sgaypq 287 7 is be VBZ cord-313694-p2sgaypq 287 8 the the DT cord-313694-p2sgaypq 287 9 role role NN cord-313694-p2sgaypq 287 10 of of IN cord-313694-p2sgaypq 287 11 the the DT cord-313694-p2sgaypq 287 12 carbohydrate carbohydrate NN cord-313694-p2sgaypq 287 13 binding bind VBG cord-313694-p2sgaypq 287 14 activity activity NN cord-313694-p2sgaypq 287 15 . . . cord-313694-p2sgaypq 288 1 There there EX cord-313694-p2sgaypq 288 2 is be VBZ cord-313694-p2sgaypq 288 3 evidence evidence NN cord-313694-p2sgaypq 288 4 that that IN cord-313694-p2sgaypq 288 5 it -PRON- PRP cord-313694-p2sgaypq 288 6 does do VBZ cord-313694-p2sgaypq 288 7 not not RB cord-313694-p2sgaypq 288 8 associate associate VB cord-313694-p2sgaypq 288 9 with with IN cord-313694-p2sgaypq 288 10 the the DT cord-313694-p2sgaypq 288 11 cell cell NN cord-313694-p2sgaypq 288 12 via via IN cord-313694-p2sgaypq 288 13 this this DT cord-313694-p2sgaypq 288 14 site site NN cord-313694-p2sgaypq 288 15 ( ( -LRB- cord-313694-p2sgaypq 288 16 103 103 CD cord-313694-p2sgaypq 288 17 ) ) -RRB- cord-313694-p2sgaypq 288 18 . . . cord-313694-p2sgaypq 289 1 It -PRON- PRP cord-313694-p2sgaypq 289 2 is be VBZ cord-313694-p2sgaypq 289 3 unclear unclear JJ cord-313694-p2sgaypq 289 4 whether whether IN cord-313694-p2sgaypq 289 5 the the DT cord-313694-p2sgaypq 289 6 carbohydrate carbohydrate NN cord-313694-p2sgaypq 289 7 - - HYPH cord-313694-p2sgaypq 289 8 binding bind VBG cord-313694-p2sgaypq 289 9 site site NN cord-313694-p2sgaypq 289 10 might may MD cord-313694-p2sgaypq 289 11 associate associate VB cord-313694-p2sgaypq 289 12 the the DT cord-313694-p2sgaypq 289 13 protein protein NN cord-313694-p2sgaypq 289 14 with with IN cord-313694-p2sgaypq 289 15 elements element NNS cord-313694-p2sgaypq 289 16 of of IN cord-313694-p2sgaypq 289 17 certain certain JJ cord-313694-p2sgaypq 289 18 substrata substrata NNS cord-313694-p2sgaypq 289 19 , , , cord-313694-p2sgaypq 289 20 but but CC cord-313694-p2sgaypq 289 21 it -PRON- PRP cord-313694-p2sgaypq 289 22 is be VBZ cord-313694-p2sgaypq 289 23 apparent apparent JJ cord-313694-p2sgaypq 289 24 that that IN cord-313694-p2sgaypq 289 25 this this DT cord-313694-p2sgaypq 289 26 is be VBZ cord-313694-p2sgaypq 289 27 not not RB cord-313694-p2sgaypq 289 28 necessary necessary JJ cord-313694-p2sgaypq 289 29 . . . cord-313694-p2sgaypq 290 1 There there EX cord-313694-p2sgaypq 290 2 is be VBZ cord-313694-p2sgaypq 290 3 recent recent JJ cord-313694-p2sgaypq 290 4 evidence evidence NN cord-313694-p2sgaypq 290 5 that that IN cord-313694-p2sgaypq 290 6 food food NN cord-313694-p2sgaypq 290 7 bacteria bacteria NNS cord-313694-p2sgaypq 290 8 are be VBP cord-313694-p2sgaypq 290 9 recognized recognize VBN cord-313694-p2sgaypq 290 10 by by IN cord-313694-p2sgaypq 290 11 this this DT cord-313694-p2sgaypq 290 12 lectin lectin NN cord-313694-p2sgaypq 290 13 and and CC cord-313694-p2sgaypq 290 14 hence hence RB cord-313694-p2sgaypq 290 15 discoidin discoidin NNP cord-313694-p2sgaypq 291 1 I -PRON- PRP cord-313694-p2sgaypq 291 2 might may MD cord-313694-p2sgaypq 291 3 assist assist VB cord-313694-p2sgaypq 291 4 in in IN cord-313694-p2sgaypq 291 5 the the DT cord-313694-p2sgaypq 291 6 adhesion adhesion NN cord-313694-p2sgaypq 291 7 of of IN cord-313694-p2sgaypq 291 8 ceils ceil NNS cord-313694-p2sgaypq 291 9 to to IN cord-313694-p2sgaypq 291 10 their -PRON- PRP$ cord-313694-p2sgaypq 291 11 food food NN cord-313694-p2sgaypq 291 12 source source NN cord-313694-p2sgaypq 291 13 ( ( -LRB- cord-313694-p2sgaypq 291 14 104 104 CD cord-313694-p2sgaypq 291 15 ) ) -RRB- cord-313694-p2sgaypq 291 16 . . . cord-313694-p2sgaypq 292 1 Perhaps perhaps RB cord-313694-p2sgaypq 292 2 the the DT cord-313694-p2sgaypq 292 3 best well RBS cord-313694-p2sgaypq 292 4 documented document VBN cord-313694-p2sgaypq 292 5 instance instance NN cord-313694-p2sgaypq 292 6 of of IN cord-313694-p2sgaypq 292 7 a a DT cord-313694-p2sgaypq 292 8 direct direct JJ cord-313694-p2sgaypq 292 9 role role NN cord-313694-p2sgaypq 292 10 for for IN cord-313694-p2sgaypq 292 11 carbohydrate carbohydrate NN cord-313694-p2sgaypq 292 12 in in IN cord-313694-p2sgaypq 292 13 cell cell NN cord-313694-p2sgaypq 292 14 - - HYPH cord-313694-p2sgaypq 292 15 cell cell NN cord-313694-p2sgaypq 292 16 adhesion adhesion NN cord-313694-p2sgaypq 292 17 occurs occur VBZ cord-313694-p2sgaypq 292 18 in in IN cord-313694-p2sgaypq 292 19 higher high JJR cord-313694-p2sgaypq 292 20 organisms organism NNS cord-313694-p2sgaypq 292 21 and and CC cord-313694-p2sgaypq 292 22 involves involve VBZ cord-313694-p2sgaypq 292 23 the the DT cord-313694-p2sgaypq 292 24 protein protein NN cord-313694-p2sgaypq 292 25 galactosyltransferase galactosyltransferase NN cord-313694-p2sgaypq 292 26 and and CC cord-313694-p2sgaypq 292 27 bound bind VBD cord-313694-p2sgaypq 292 28 GlcNAc GlcNAc NNP cord-313694-p2sgaypq 292 29 , , , cord-313694-p2sgaypq 292 30 sometimes sometimes RB cord-313694-p2sgaypq 292 31 associated associate VBN cord-313694-p2sgaypq 292 32 with with IN cord-313694-p2sgaypq 292 33 oligolactosamine oligolactosamine NNP cord-313694-p2sgaypq 292 34 ( ( -LRB- cord-313694-p2sgaypq 292 35 120 120 CD cord-313694-p2sgaypq 292 36 , , , cord-313694-p2sgaypq 292 37 121 121 CD cord-313694-p2sgaypq 292 38 , , , cord-313694-p2sgaypq 292 39 74 74 CD cord-313694-p2sgaypq 292 40 , , , cord-313694-p2sgaypq 292 41 124 124 CD cord-313694-p2sgaypq 292 42 ) ) -RRB- cord-313694-p2sgaypq 292 43 . . . cord-313694-p2sgaypq 293 1 This this DT cord-313694-p2sgaypq 293 2 pair pair NN cord-313694-p2sgaypq 293 3 of of IN cord-313694-p2sgaypq 293 4 molecules molecule NNS cord-313694-p2sgaypq 293 5 has have VBZ cord-313694-p2sgaypq 293 6 been be VBN cord-313694-p2sgaypq 293 7 implicated implicate VBN cord-313694-p2sgaypq 293 8 in in IN cord-313694-p2sgaypq 293 9 adhesion adhesion NN cord-313694-p2sgaypq 293 10 between between IN cord-313694-p2sgaypq 293 11 mouse mouse NN cord-313694-p2sgaypq 293 12 sperm sperm NN cord-313694-p2sgaypq 293 13 and and CC cord-313694-p2sgaypq 293 14 egg egg NN cord-313694-p2sgaypq 293 15 , , , cord-313694-p2sgaypq 293 16 neural neural JJ cord-313694-p2sgaypq 293 17 crest crest NN cord-313694-p2sgaypq 293 18 cells cell NNS cord-313694-p2sgaypq 293 19 and and CC cord-313694-p2sgaypq 293 20 substrated substrate VBN cord-313694-p2sgaypq 293 21 , , , cord-313694-p2sgaypq 293 22 and and CC cord-313694-p2sgaypq 293 23 embryonal embryonal JJ cord-313694-p2sgaypq 293 24 carcinoma carcinoma NNP cord-313694-p2sgaypq 293 25 ceils ceils NNP cord-313694-p2sgaypq 293 26 . . . cord-313694-p2sgaypq 294 1 Each each DT cord-313694-p2sgaypq 294 2 of of IN cord-313694-p2sgaypq 294 3 the the DT cord-313694-p2sgaypq 294 4 four four CD cord-313694-p2sgaypq 294 5 criteria criterion NNS cord-313694-p2sgaypq 294 6 cited cite VBN cord-313694-p2sgaypq 294 7 above above RB cord-313694-p2sgaypq 294 8 has have VBZ cord-313694-p2sgaypq 294 9 been be VBN cord-313694-p2sgaypq 294 10 addressed address VBN cord-313694-p2sgaypq 294 11 by by IN cord-313694-p2sgaypq 294 12 experimental experimental JJ cord-313694-p2sgaypq 294 13 approaches approach NNS cord-313694-p2sgaypq 294 14 using use VBG cord-313694-p2sgaypq 294 15 antibodies antibody NNS cord-313694-p2sgaypq 294 16 , , , cord-313694-p2sgaypq 294 17 enzymes enzyme NNS cord-313694-p2sgaypq 294 18 and and CC cord-313694-p2sgaypq 294 19 drugs drug NNS cord-313694-p2sgaypq 294 20 to to TO cord-313694-p2sgaypq 294 21 inactivate inactivate VB cord-313694-p2sgaypq 294 22 the the DT cord-313694-p2sgaypq 294 23 receptor receptor NN cord-313694-p2sgaypq 294 24 and and CC cord-313694-p2sgaypq 294 25 the the DT cord-313694-p2sgaypq 294 26 ligand ligand NN cord-313694-p2sgaypq 294 27 . . . cord-313694-p2sgaypq 295 1 A a DT cord-313694-p2sgaypq 295 2 genetic genetic JJ cord-313694-p2sgaypq 295 3 approach approach NN cord-313694-p2sgaypq 295 4 to to TO cord-313694-p2sgaypq 295 5 modify modify VB cord-313694-p2sgaypq 295 6 receptor receptor NN cord-313694-p2sgaypq 295 7 or or CC cord-313694-p2sgaypq 295 8 ligand ligand NN cord-313694-p2sgaypq 295 9 has have VBZ cord-313694-p2sgaypq 295 10 yet yet RB cord-313694-p2sgaypq 295 11 to to TO cord-313694-p2sgaypq 295 12 be be VB cord-313694-p2sgaypq 295 13 applied apply VBN cord-313694-p2sgaypq 295 14 . . . cord-313694-p2sgaypq 296 1 Though though IN cord-313694-p2sgaypq 296 2 the the DT cord-313694-p2sgaypq 296 3 latter latter JJ cord-313694-p2sgaypq 296 4 approach approach NN cord-313694-p2sgaypq 296 5 with with IN cord-313694-p2sgaypq 296 6 its -PRON- PRP$ cord-313694-p2sgaypq 296 7 inherent inherent JJ cord-313694-p2sgaypq 296 8 specificity specificity NN cord-313694-p2sgaypq 296 9 is be VBZ cord-313694-p2sgaypq 296 10 very very RB cord-313694-p2sgaypq 296 11 important important JJ cord-313694-p2sgaypq 296 12 , , , cord-313694-p2sgaypq 296 13 the the DT cord-313694-p2sgaypq 296 14 evidence evidence NN cord-313694-p2sgaypq 296 15 using use VBG cord-313694-p2sgaypq 296 16 the the DT cord-313694-p2sgaypq 296 17 approaches approach NNS cord-313694-p2sgaypq 296 18 already already RB cord-313694-p2sgaypq 296 19 employed employ VBN cord-313694-p2sgaypq 296 20 is be VBZ cord-313694-p2sgaypq 296 21 strong strong JJ cord-313694-p2sgaypq 296 22 . . . cord-313694-p2sgaypq 297 1 The the DT cord-313694-p2sgaypq 297 2 system system NN cord-313694-p2sgaypq 297 3 is be VBZ cord-313694-p2sgaypq 297 4 interesting interesting JJ cord-313694-p2sgaypq 297 5 because because IN cord-313694-p2sgaypq 297 6 the the DT cord-313694-p2sgaypq 297 7 receptor receptor NN cord-313694-p2sgaypq 297 8 - - HYPH cord-313694-p2sgaypq 297 9 ligand ligand NN cord-313694-p2sgaypq 297 10 interaction interaction NN cord-313694-p2sgaypq 297 11 can can MD cord-313694-p2sgaypq 297 12 be be VB cord-313694-p2sgaypq 297 13 readily readily RB cord-313694-p2sgaypq 297 14 reversed reverse VBN cord-313694-p2sgaypq 297 15 by by IN cord-313694-p2sgaypq 297 16 supplying supply VBG cord-313694-p2sgaypq 297 17 substrate substrate NN cord-313694-p2sgaypq 297 18 for for IN cord-313694-p2sgaypq 297 19 the the DT cord-313694-p2sgaypq 297 20 galactosyltransferase galactosyltransferase NN cord-313694-p2sgaypq 297 21 enzyme enzyme NN cord-313694-p2sgaypq 297 22 activity activity NN cord-313694-p2sgaypq 297 23 . . . cord-313694-p2sgaypq 298 1 An an DT cord-313694-p2sgaypq 298 2 independent independent JJ cord-313694-p2sgaypq 298 3 approach approach NN cord-313694-p2sgaypq 298 4 to to IN cord-313694-p2sgaypq 298 5 the the DT cord-313694-p2sgaypq 298 6 problem problem NN cord-313694-p2sgaypq 298 7 of of IN cord-313694-p2sgaypq 298 8 mouse mouse NN cord-313694-p2sgaypq 298 9 sperm sperm NN cord-313694-p2sgaypq 298 10 - - HYPH cord-313694-p2sgaypq 298 11 egg egg NN cord-313694-p2sgaypq 298 12 recognition recognition NN cord-313694-p2sgaypq 298 13 has have VBZ cord-313694-p2sgaypq 298 14 resulted result VBN cord-313694-p2sgaypq 298 15 in in IN cord-313694-p2sgaypq 298 16 the the DT cord-313694-p2sgaypq 298 17 isolation isolation NN cord-313694-p2sgaypq 298 18 , , , cord-313694-p2sgaypq 298 19 from from IN cord-313694-p2sgaypq 298 20 the the DT cord-313694-p2sgaypq 298 21 jelly jelly NN cord-313694-p2sgaypq 298 22 coat coat NN cord-313694-p2sgaypq 298 23 of of IN cord-313694-p2sgaypq 298 24 the the DT cord-313694-p2sgaypq 298 25 egg egg NN cord-313694-p2sgaypq 298 26 , , , cord-313694-p2sgaypq 298 27 of of IN cord-313694-p2sgaypq 298 28 a a DT cord-313694-p2sgaypq 298 29 glycoprotein glycoprotein NN cord-313694-p2sgaypq 298 30 , , , cord-313694-p2sgaypq 298 31 ZP3 ZP3 NNP cord-313694-p2sgaypq 298 32 , , , cord-313694-p2sgaypq 298 33 which which WDT cord-313694-p2sgaypq 298 34 can can MD cord-313694-p2sgaypq 298 35 , , , cord-313694-p2sgaypq 298 36 upon upon IN cord-313694-p2sgaypq 298 37 presentation presentation NN cord-313694-p2sgaypq 298 38 to to IN cord-313694-p2sgaypq 298 39 the the DT cord-313694-p2sgaypq 298 40 sperm sperm NN cord-313694-p2sgaypq 298 41 , , , cord-313694-p2sgaypq 298 42 block block VB cord-313694-p2sgaypq 298 43 its -PRON- PRP$ cord-313694-p2sgaypq 298 44 ability ability NN cord-313694-p2sgaypq 298 45 to to TO cord-313694-p2sgaypq 298 46 recognize recognize VB cord-313694-p2sgaypq 298 47 eggs egg NNS cord-313694-p2sgaypq 298 48 ( ( -LRB- cord-313694-p2sgaypq 298 49 125 125 CD cord-313694-p2sgaypq 298 50 ) ) -RRB- cord-313694-p2sgaypq 298 51 . . . cord-313694-p2sgaypq 299 1 It -PRON- PRP cord-313694-p2sgaypq 299 2 was be VBD cord-313694-p2sgaypq 299 3 found find VBN cord-313694-p2sgaypq 299 4 that that IN cord-313694-p2sgaypq 299 5 careful careful JJ cord-313694-p2sgaypq 299 6 alkaline alkaline JJ cord-313694-p2sgaypq 299 7 borohydride borohydride NN cord-313694-p2sgaypq 299 8 treatment treatment NN cord-313694-p2sgaypq 299 9 to to TO cord-313694-p2sgaypq 299 10 strip strip VB cord-313694-p2sgaypq 299 11 O O NNP cord-313694-p2sgaypq 299 12 - - HYPH cord-313694-p2sgaypq 299 13 linked link VBN cord-313694-p2sgaypq 299 14 glycans glycan NNS cord-313694-p2sgaypq 299 15 without without IN cord-313694-p2sgaypq 299 16 altering alter VBG cord-313694-p2sgaypq 299 17 the the DT cord-313694-p2sgaypq 299 18 polypeptide polypeptide NN cord-313694-p2sgaypq 299 19 chain chain NN cord-313694-p2sgaypq 299 20 neutralized neutralize VBD cord-313694-p2sgaypq 299 21 the the DT cord-313694-p2sgaypq 299 22 inhibitory inhibitory JJ cord-313694-p2sgaypq 299 23 activity activity NN cord-313694-p2sgaypq 299 24 of of IN cord-313694-p2sgaypq 299 25 ZP3 ZP3 NNP cord-313694-p2sgaypq 299 26 . . . cord-313694-p2sgaypq 300 1 Finally finally RB cord-313694-p2sgaypq 300 2 , , , cord-313694-p2sgaypq 300 3 it -PRON- PRP cord-313694-p2sgaypq 300 4 was be VBD cord-313694-p2sgaypq 300 5 shown show VBN cord-313694-p2sgaypq 300 6 that that IN cord-313694-p2sgaypq 300 7 the the DT cord-313694-p2sgaypq 300 8 released release VBN cord-313694-p2sgaypq 300 9 glycans glycan NNS cord-313694-p2sgaypq 300 10 possessed possess VBD cord-313694-p2sgaypq 300 11 inhibitory inhibitory JJ cord-313694-p2sgaypq 300 12 activity activity NN cord-313694-p2sgaypq 300 13 and and CC cord-313694-p2sgaypq 300 14 in in IN cord-313694-p2sgaypq 300 15 addition addition NN cord-313694-p2sgaypq 300 16 bound bind VBN cord-313694-p2sgaypq 300 17 to to IN cord-313694-p2sgaypq 300 18 sperm sperm NN cord-313694-p2sgaypq 300 19 , , , cord-313694-p2sgaypq 300 20 suggesting suggest VBG cord-313694-p2sgaypq 300 21 that that IN cord-313694-p2sgaypq 300 22 the the DT cord-313694-p2sgaypq 300 23 carbohydrate carbohydrate NN cord-313694-p2sgaypq 300 24 itself -PRON- PRP cord-313694-p2sgaypq 300 25 served serve VBD cord-313694-p2sgaypq 300 26 as as IN cord-313694-p2sgaypq 300 27 the the DT cord-313694-p2sgaypq 300 28 recognition recognition NN cord-313694-p2sgaypq 300 29 site site NN cord-313694-p2sgaypq 300 30 in in IN cord-313694-p2sgaypq 300 31 the the DT cord-313694-p2sgaypq 300 32 jelly jelly NN cord-313694-p2sgaypq 300 33 coat coat NN cord-313694-p2sgaypq 300 34 for for IN cord-313694-p2sgaypq 300 35 sperm sperm NN cord-313694-p2sgaypq 300 36 . . . cord-313694-p2sgaypq 301 1 Further further JJ cord-313694-p2sgaypq 301 2 work work NN cord-313694-p2sgaypq 301 3 remains remain VBZ cord-313694-p2sgaypq 301 4 to to TO cord-313694-p2sgaypq 301 5 be be VB cord-313694-p2sgaypq 301 6 done do VBN cord-313694-p2sgaypq 301 7 to to TO cord-313694-p2sgaypq 301 8 identify identify VB cord-313694-p2sgaypq 301 9 the the DT cord-313694-p2sgaypq 301 10 sperm sperm NN cord-313694-p2sgaypq 301 11 receptor receptor NN cord-313694-p2sgaypq 301 12 ( ( -LRB- cord-313694-p2sgaypq 301 13 169 169 CD cord-313694-p2sgaypq 301 14 ) ) -RRB- cord-313694-p2sgaypq 301 15 as as RB cord-313694-p2sgaypq 301 16 well well RB cord-313694-p2sgaypq 301 17 as as IN cord-313694-p2sgaypq 301 18 to to TO cord-313694-p2sgaypq 301 19 relate relate VB cord-313694-p2sgaypq 301 20 the the DT cord-313694-p2sgaypq 301 21 findings finding NNS cord-313694-p2sgaypq 301 22 to to IN cord-313694-p2sgaypq 301 23 the the DT cord-313694-p2sgaypq 301 24 above above JJ cord-313694-p2sgaypq 301 25 results result NNS cord-313694-p2sgaypq 301 26 implicating implicate VBG cord-313694-p2sgaypq 301 27 the the DT cord-313694-p2sgaypq 301 28 galactosyltransferase galactosyltransferase NN cord-313694-p2sgaypq 301 29 . . . cord-313694-p2sgaypq 302 1 Carbohydrate carbohydrate NN cord-313694-p2sgaypq 302 2 of of IN cord-313694-p2sgaypq 302 3 a a DT cord-313694-p2sgaypq 302 4 different different JJ cord-313694-p2sgaypq 302 5 type type NN cord-313694-p2sgaypq 302 6 has have VBZ cord-313694-p2sgaypq 302 7 also also RB cord-313694-p2sgaypq 302 8 been be VBN cord-313694-p2sgaypq 302 9 implicated implicate VBN cord-313694-p2sgaypq 302 10 in in IN cord-313694-p2sgaypq 302 11 cell cell NN cord-313694-p2sgaypq 302 12 - - HYPH cord-313694-p2sgaypq 302 13 cell cell NN cord-313694-p2sgaypq 302 14 adhesion adhesion NN cord-313694-p2sgaypq 302 15 between between IN cord-313694-p2sgaypq 302 16 mature mature JJ cord-313694-p2sgaypq 302 17 mammalian mammalian JJ cord-313694-p2sgaypq 302 18 cells cell NNS cord-313694-p2sgaypq 302 19 . . . cord-313694-p2sgaypq 303 1 For for IN cord-313694-p2sgaypq 303 2 example example NN cord-313694-p2sgaypq 303 3 , , , cord-313694-p2sgaypq 303 4 it -PRON- PRP cord-313694-p2sgaypq 303 5 has have VBZ cord-313694-p2sgaypq 303 6 been be VBN cord-313694-p2sgaypq 303 7 suggested suggest VBN cord-313694-p2sgaypq 303 8 that that IN cord-313694-p2sgaypq 303 9 cell cell NN cord-313694-p2sgaypq 303 10 surface surface NN cord-313694-p2sgaypq 303 11 carbohydrate carbohydrate NN cord-313694-p2sgaypq 303 12 may may MD cord-313694-p2sgaypq 303 13 be be VB cord-313694-p2sgaypq 303 14 important important JJ cord-313694-p2sgaypq 303 15 for for IN cord-313694-p2sgaypq 303 16 recognition recognition NN cord-313694-p2sgaypq 303 17 between between IN cord-313694-p2sgaypq 303 18 certain certain JJ cord-313694-p2sgaypq 303 19 lymphocytes lymphocyte NNS cord-313694-p2sgaypq 303 20 and and CC cord-313694-p2sgaypq 303 21 certain certain JJ cord-313694-p2sgaypq 303 22 high high JJ cord-313694-p2sgaypq 303 23 endothelial endothelial JJ cord-313694-p2sgaypq 303 24 venule venule NN cord-313694-p2sgaypq 303 25 surfaces surface NNS cord-313694-p2sgaypq 303 26 ( ( -LRB- cord-313694-p2sgaypq 303 27 HEV HEV NNP cord-313694-p2sgaypq 303 28 ) ) -RRB- cord-313694-p2sgaypq 303 29 in in IN cord-313694-p2sgaypq 303 30 lymphatic lymphatic JJ cord-313694-p2sgaypq 303 31 tissues tissue NNS cord-313694-p2sgaypq 303 32 ( ( -LRB- cord-313694-p2sgaypq 303 33 136 136 CD cord-313694-p2sgaypq 303 34 ) ) -RRB- cord-313694-p2sgaypq 303 35 . . . cord-313694-p2sgaypq 304 1 Pretreatment pretreatment NN cord-313694-p2sgaypq 304 2 of of IN cord-313694-p2sgaypq 304 3 lymphocytes lymphocyte NNS cord-313694-p2sgaypq 304 4 with with IN cord-313694-p2sgaypq 304 5 specific specific JJ cord-313694-p2sgaypq 304 6 sugars sugar NNS cord-313694-p2sgaypq 304 7 renders render VBZ cord-313694-p2sgaypq 304 8 them -PRON- PRP cord-313694-p2sgaypq 304 9 incapable incapable JJ cord-313694-p2sgaypq 304 10 of of IN cord-313694-p2sgaypq 304 11 binding bind VBG cord-313694-p2sgaypq 304 12 to to IN cord-313694-p2sgaypq 304 13 HEVs hev NNS cord-313694-p2sgaypq 304 14 in in IN cord-313694-p2sgaypq 304 15 an an DT cord-313694-p2sgaypq 304 16 in in FW cord-313694-p2sgaypq 304 17 vitro vitro FW cord-313694-p2sgaypq 304 18 assay assay NN cord-313694-p2sgaypq 304 19 , , , cord-313694-p2sgaypq 304 20 and and CC cord-313694-p2sgaypq 304 21 glycosidase glycosidase NN cord-313694-p2sgaypq 304 22 treatment treatment NN cord-313694-p2sgaypq 304 23 of of IN cord-313694-p2sgaypq 304 24 HEVs hev NNS cord-313694-p2sgaypq 304 25 renders render VBZ cord-313694-p2sgaypq 304 26 them -PRON- PRP cord-313694-p2sgaypq 304 27 incapable incapable JJ cord-313694-p2sgaypq 304 28 of of IN cord-313694-p2sgaypq 304 29 being be VBG cord-313694-p2sgaypq 304 30 recognized recognize VBN cord-313694-p2sgaypq 304 31 by by IN cord-313694-p2sgaypq 304 32 lymphocytes lymphocyte NNS cord-313694-p2sgaypq 304 33 . . . cord-313694-p2sgaypq 305 1 There there EX cord-313694-p2sgaypq 305 2 is be VBZ cord-313694-p2sgaypq 305 3 conflicting conflict VBG cord-313694-p2sgaypq 305 4 evidence evidence NN cord-313694-p2sgaypq 305 5 from from IN cord-313694-p2sgaypq 305 6 these these DT cord-313694-p2sgaypq 305 7 studies study NNS cord-313694-p2sgaypq 305 8 regarding regard VBG cord-313694-p2sgaypq 305 9 the the DT cord-313694-p2sgaypq 305 10 nature nature NN cord-313694-p2sgaypq 305 11 of of IN cord-313694-p2sgaypq 305 12 the the DT cord-313694-p2sgaypq 305 13 carbohydrate carbohydrate NN cord-313694-p2sgaypq 305 14 structure structure NN cord-313694-p2sgaypq 305 15 involved involve VBN cord-313694-p2sgaypq 305 16 . . . cord-313694-p2sgaypq 306 1 Additional additional JJ cord-313694-p2sgaypq 306 2 results result NNS cord-313694-p2sgaypq 306 3 have have VBP cord-313694-p2sgaypq 306 4 indicated indicate VBN cord-313694-p2sgaypq 306 5 that that IN cord-313694-p2sgaypq 306 6 one one CD cord-313694-p2sgaypq 306 7 lymphocyte lymphocyte NN cord-313694-p2sgaypq 306 8 subclass subclass NN cord-313694-p2sgaypq 306 9 recognition recognition NN cord-313694-p2sgaypq 306 10 site site NN cord-313694-p2sgaypq 306 11 involves involve VBZ cord-313694-p2sgaypq 306 12 a a DT cord-313694-p2sgaypq 306 13 previously previously RB cord-313694-p2sgaypq 306 14 studied study VBN cord-313694-p2sgaypq 306 15 homing homing NN cord-313694-p2sgaypq 306 16 receptor receptor NN cord-313694-p2sgaypq 306 17 , , , cord-313694-p2sgaypq 306 18 the the DT cord-313694-p2sgaypq 306 19 ubiquitin ubiquitin NN cord-313694-p2sgaypq 306 20 - - HYPH cord-313694-p2sgaypq 306 21 conjugated conjugate VBN cord-313694-p2sgaypq 306 22 glycoprotein glycoprotein NN cord-313694-p2sgaypq 306 23 defined define VBN cord-313694-p2sgaypq 306 24 by by IN cord-313694-p2sgaypq 306 25 the the DT cord-313694-p2sgaypq 306 26 MEL-14 MEL-14 NNP cord-313694-p2sgaypq 306 27 antigen antigen NN cord-313694-p2sgaypq 306 28 . . . cord-313694-p2sgaypq 307 1 Recent recent JJ cord-313694-p2sgaypq 307 2 work work NN cord-313694-p2sgaypq 307 3 has have VBZ cord-313694-p2sgaypq 307 4 found find VBN cord-313694-p2sgaypq 307 5 carbohydrate carbohydrate NN cord-313694-p2sgaypq 307 6 - - HYPH cord-313694-p2sgaypq 307 7 derivatized derivatized JJ cord-313694-p2sgaypq 307 8 polyacrylamide polyacrylamide NN cord-313694-p2sgaypq 307 9 surfaces surface NNS cord-313694-p2sgaypq 307 10 to to IN cord-313694-p2sgaypq 307 11 which which WDT cord-313694-p2sgaypq 307 12 lymphocytes lymphocyte NNS cord-313694-p2sgaypq 307 13 will will MD cord-313694-p2sgaypq 307 14 specifically specifically RB cord-313694-p2sgaypq 307 15 bind bind VB cord-313694-p2sgaypq 307 16 ( ( -LRB- cord-313694-p2sgaypq 307 17 137 137 CD cord-313694-p2sgaypq 307 18 ) ) -RRB- cord-313694-p2sgaypq 307 19 . . . cord-313694-p2sgaypq 308 1 An an DT cord-313694-p2sgaypq 308 2 effort effort NN cord-313694-p2sgaypq 308 3 is be VBZ cord-313694-p2sgaypq 308 4 underway underway JJ cord-313694-p2sgaypq 308 5 to to TO cord-313694-p2sgaypq 308 6 compare compare VB cord-313694-p2sgaypq 308 7 the the DT cord-313694-p2sgaypq 308 8 specificity specificity NN cord-313694-p2sgaypq 308 9 of of IN cord-313694-p2sgaypq 308 10 this this DT cord-313694-p2sgaypq 308 11 interaction interaction NN cord-313694-p2sgaypq 308 12 with with IN cord-313694-p2sgaypq 308 13 that that DT cord-313694-p2sgaypq 308 14 to to IN cord-313694-p2sgaypq 308 15 HEVs hev NNS cord-313694-p2sgaypq 308 16 . . . cord-313694-p2sgaypq 309 1 The the DT cord-313694-p2sgaypq 309 2 exciting exciting JJ cord-313694-p2sgaypq 309 3 prospect prospect NN cord-313694-p2sgaypq 309 4 is be VBZ cord-313694-p2sgaypq 309 5 that that IN cord-313694-p2sgaypq 309 6 the the DT cord-313694-p2sgaypq 309 7 manipulability manipulability NN cord-313694-p2sgaypq 309 8 of of IN cord-313694-p2sgaypq 309 9 the the DT cord-313694-p2sgaypq 309 10 artificial artificial JJ cord-313694-p2sgaypq 309 11 surface surface NN cord-313694-p2sgaypq 309 12 ( ( -LRB- cord-313694-p2sgaypq 309 13 130 130 CD cord-313694-p2sgaypq 309 14 ) ) -RRB- cord-313694-p2sgaypq 309 15 will will MD cord-313694-p2sgaypq 309 16 allow allow VB cord-313694-p2sgaypq 309 17 dissection dissection NN cord-313694-p2sgaypq 309 18 of of IN cord-313694-p2sgaypq 309 19 multiple multiple JJ cord-313694-p2sgaypq 309 20 adhesion adhesion NN cord-313694-p2sgaypq 309 21 mechanisms mechanism NNS cord-313694-p2sgaypq 309 22 and and CC cord-313694-p2sgaypq 309 23 permit permit VBP cord-313694-p2sgaypq 309 24 more more RBR cord-313694-p2sgaypq 309 25 rapid rapid JJ cord-313694-p2sgaypq 309 26 investigation investigation NN cord-313694-p2sgaypq 309 27 of of IN cord-313694-p2sgaypq 309 28 the the DT cord-313694-p2sgaypq 309 29 nature nature NN cord-313694-p2sgaypq 309 30 of of IN cord-313694-p2sgaypq 309 31 the the DT cord-313694-p2sgaypq 309 32 carbohydrate carbohydrate NN cord-313694-p2sgaypq 309 33 recognition recognition NN cord-313694-p2sgaypq 309 34 system system NN cord-313694-p2sgaypq 309 35 believed believe VBD cord-313694-p2sgaypq 309 36 to to TO cord-313694-p2sgaypq 309 37 be be VB cord-313694-p2sgaypq 309 38 responsible responsible JJ cord-313694-p2sgaypq 309 39 for for IN cord-313694-p2sgaypq 309 40 lymphocyte lymphocyte NN cord-313694-p2sgaypq 309 41 recognition recognition NN cord-313694-p2sgaypq 309 42 preparatory preparatory JJ cord-313694-p2sgaypq 309 43 to to IN cord-313694-p2sgaypq 309 44 extravasation extravasation NN cord-313694-p2sgaypq 309 45 . . . cord-313694-p2sgaypq 310 1 Carbohydrate carbohydrate NN cord-313694-p2sgaypq 310 2 has have VBZ cord-313694-p2sgaypq 310 3 been be VBN cord-313694-p2sgaypq 310 4 suggested suggest VBN cord-313694-p2sgaypq 310 5 to to TO cord-313694-p2sgaypq 310 6 perform perform VB cord-313694-p2sgaypq 310 7 an an DT cord-313694-p2sgaypq 310 8 opposite opposite JJ cord-313694-p2sgaypq 310 9 kind kind NN cord-313694-p2sgaypq 310 10 of of IN cord-313694-p2sgaypq 310 11 role role NN cord-313694-p2sgaypq 310 12 in in IN cord-313694-p2sgaypq 310 13 the the DT cord-313694-p2sgaypq 310 14 function function NN cord-313694-p2sgaypq 310 15 of of IN cord-313694-p2sgaypq 310 16 the the DT cord-313694-p2sgaypq 310 17 protein protein NN cord-313694-p2sgaypq 310 18 N N NNP cord-313694-p2sgaypq 310 19 - - HYPH cord-313694-p2sgaypq 310 20 CAM CAM NNP cord-313694-p2sgaypq 310 21 in in IN cord-313694-p2sgaypq 310 22 associating associate VBG cord-313694-p2sgaypq 310 23 neural neural JJ cord-313694-p2sgaypq 310 24 cells cell NNS cord-313694-p2sgaypq 310 25 ( ( -LRB- cord-313694-p2sgaypq 310 26 170 170 CD cord-313694-p2sgaypq 310 27 ) ) -RRB- cord-313694-p2sgaypq 310 28 . . . cord-313694-p2sgaypq 311 1 Fab fab JJ cord-313694-p2sgaypq 311 2 fragments fragment NNS cord-313694-p2sgaypq 311 3 from from IN cord-313694-p2sgaypq 311 4 anti anti JJ cord-313694-p2sgaypq 311 5 - - JJ cord-313694-p2sgaypq 311 6 N n JJ cord-313694-p2sgaypq 311 7 - - HYPH cord-313694-p2sgaypq 311 8 CAM CAM NNP cord-313694-p2sgaypq 311 9 inhibit inhibit VB cord-313694-p2sgaypq 311 10 reassociation reassociation NN cord-313694-p2sgaypq 311 11 of of IN cord-313694-p2sgaypq 311 12 dissociated dissociated JJ cord-313694-p2sgaypq 311 13 neural neural JJ cord-313694-p2sgaypq 311 14 cells cell NNS cord-313694-p2sgaypq 311 15 and and CC cord-313694-p2sgaypq 311 16 isolated isolate VBN cord-313694-p2sgaypq 311 17 N n CD cord-313694-p2sgaypq 311 18 - - HYPH cord-313694-p2sgaypq 311 19 CAM CAM NNP cord-313694-p2sgaypq 311 20 can can MD cord-313694-p2sgaypq 311 21 self self VB cord-313694-p2sgaypq 311 22 associate associate VB cord-313694-p2sgaypq 311 23 . . . cord-313694-p2sgaypq 312 1 There there EX cord-313694-p2sgaypq 312 2 are be VBP cord-313694-p2sgaypq 312 3 several several JJ cord-313694-p2sgaypq 312 4 forms form NNS cord-313694-p2sgaypq 312 5 of of IN cord-313694-p2sgaypq 312 6 N n CD cord-313694-p2sgaypq 312 7 - - HYPH cord-313694-p2sgaypq 312 8 CAM CAM NNP cord-313694-p2sgaypq 312 9 which which WDT cord-313694-p2sgaypq 312 10 differ differ VBP cord-313694-p2sgaypq 312 11 in in IN cord-313694-p2sgaypq 312 12 their -PRON- PRP$ cord-313694-p2sgaypq 312 13 degree degree NN cord-313694-p2sgaypq 312 14 of of IN cord-313694-p2sgaypq 312 15 sialylation sialylation NN cord-313694-p2sgaypq 312 16 . . . cord-313694-p2sgaypq 313 1 The the DT cord-313694-p2sgaypq 313 2 more more RBR cord-313694-p2sgaypq 313 3 heavily heavily RB cord-313694-p2sgaypq 313 4 sialylated sialylate VBN cord-313694-p2sgaypq 313 5 forms form NNS cord-313694-p2sgaypq 313 6 show show VBP cord-313694-p2sgaypq 313 7 less less JJR cord-313694-p2sgaypq 313 8 affinity affinity NN cord-313694-p2sgaypq 313 9 for for IN cord-313694-p2sgaypq 313 10 one one CD cord-313694-p2sgaypq 313 11 another another DT cord-313694-p2sgaypq 313 12 in in IN cord-313694-p2sgaypq 313 13 the the DT cord-313694-p2sgaypq 313 14 self self NN cord-313694-p2sgaypq 313 15 association association NN cord-313694-p2sgaypq 313 16 assays assays NNP cord-313694-p2sgaypq 313 17 . . . cord-313694-p2sgaypq 314 1 Thus thus RB cord-313694-p2sgaypq 314 2 it -PRON- PRP cord-313694-p2sgaypq 314 3 has have VBZ cord-313694-p2sgaypq 314 4 been be VBN cord-313694-p2sgaypq 314 5 postulated postulate VBN cord-313694-p2sgaypq 314 6 that that IN cord-313694-p2sgaypq 314 7 sialylation sialylation NN cord-313694-p2sgaypq 314 8 is be VBZ cord-313694-p2sgaypq 314 9 a a DT cord-313694-p2sgaypq 314 10 posttranslational posttranslational JJ cord-313694-p2sgaypq 314 11 modification modification NN cord-313694-p2sgaypq 314 12 which which WDT cord-313694-p2sgaypq 314 13 modulates modulate VBZ cord-313694-p2sgaypq 314 14 the the DT cord-313694-p2sgaypq 314 15 strength strength NN cord-313694-p2sgaypq 314 16 of of IN cord-313694-p2sgaypq 314 17 adhesion adhesion NN cord-313694-p2sgaypq 314 18 mediated mediate VBN cord-313694-p2sgaypq 314 19 by by IN cord-313694-p2sgaypq 314 20 this this DT cord-313694-p2sgaypq 314 21 glycoprotein glycoprotein NN cord-313694-p2sgaypq 314 22 and and CC cord-313694-p2sgaypq 314 23 in in IN cord-313694-p2sgaypq 314 24 vivo vivo NN cord-313694-p2sgaypq 314 25 evidence evidence NN cord-313694-p2sgaypq 314 26 has have VBZ cord-313694-p2sgaypq 314 27 now now RB cord-313694-p2sgaypq 314 28 been be VBN cord-313694-p2sgaypq 314 29 provided provide VBN cord-313694-p2sgaypq 314 30 ( ( -LRB- cord-313694-p2sgaypq 314 31 127 127 CD cord-313694-p2sgaypq 314 32 ) ) -RRB- cord-313694-p2sgaypq 314 33 . . . cord-313694-p2sgaypq 315 1 Recent recent JJ cord-313694-p2sgaypq 315 2 - - HYPH cord-313694-p2sgaypq 315 3 ly ly JJ cord-313694-p2sgaypq 316 1 it -PRON- PRP cord-313694-p2sgaypq 316 2 has have VBZ cord-313694-p2sgaypq 316 3 alo alo RB cord-313694-p2sgaypq 316 4 been be VBN cord-313694-p2sgaypq 316 5 suggested suggest VBN cord-313694-p2sgaypq 316 6 that that IN cord-313694-p2sgaypq 316 7 N N NNP cord-313694-p2sgaypq 316 8 - - HYPH cord-313694-p2sgaypq 316 9 CAM CAM NNP cord-313694-p2sgaypq 316 10 can can MD cord-313694-p2sgaypq 316 11 bind bind VB cord-313694-p2sgaypq 316 12 carbohydrate carbohydrate NN cord-313694-p2sgaypq 316 13 in in IN cord-313694-p2sgaypq 316 14 the the DT cord-313694-p2sgaypq 316 15 heparan heparan JJ cord-313694-p2sgaypq 316 16 sulfate sulfate NN cord-313694-p2sgaypq 316 17 proteoglycan proteoglycan NN cord-313694-p2sgaypq 316 18 ( ( -LRB- cord-313694-p2sgaypq 316 19 128 128 CD cord-313694-p2sgaypq 316 20 ) ) -RRB- cord-313694-p2sgaypq 316 21 and and CC cord-313694-p2sgaypq 316 22 that that IN cord-313694-p2sgaypq 316 23 this this DT cord-313694-p2sgaypq 316 24 recognition recognition NN cord-313694-p2sgaypq 316 25 is be VBZ cord-313694-p2sgaypq 316 26 involved involve VBN cord-313694-p2sgaypq 316 27 in in IN cord-313694-p2sgaypq 316 28 intercellular intercellular JJ cord-313694-p2sgaypq 316 29 ( ( -LRB- cord-313694-p2sgaypq 316 30 171 171 CD cord-313694-p2sgaypq 316 31 ) ) -RRB- cord-313694-p2sgaypq 316 32 and and CC cord-313694-p2sgaypq 316 33 cell cell NN cord-313694-p2sgaypq 316 34 - - HYPH cord-313694-p2sgaypq 316 35 substratum substratum NN cord-313694-p2sgaypq 316 36 adhesion adhesion NN cord-313694-p2sgaypq 316 37 . . . cord-313694-p2sgaypq 317 1 It -PRON- PRP cord-313694-p2sgaypq 317 2 is be VBZ cord-313694-p2sgaypq 317 3 too too RB cord-313694-p2sgaypq 317 4 soon soon RB cord-313694-p2sgaypq 317 5 to to TO cord-313694-p2sgaypq 317 6 speculate speculate VB cord-313694-p2sgaypq 317 7 whether whether IN cord-313694-p2sgaypq 317 8 binding bind VBG cord-313694-p2sgaypq 317 9 to to IN cord-313694-p2sgaypq 317 10 a a DT cord-313694-p2sgaypq 317 11 carbohydrate carbohydrate NN cord-313694-p2sgaypq 317 12 ligand ligand NN cord-313694-p2sgaypq 317 13 may may MD cord-313694-p2sgaypq 317 14 have have VB cord-313694-p2sgaypq 317 15 secondary secondary JJ cord-313694-p2sgaypq 317 16 effects effect NNS cord-313694-p2sgaypq 317 17 on on IN cord-313694-p2sgaypq 317 18 cells cell NNS cord-313694-p2sgaypq 317 19 as as IN cord-313694-p2sgaypq 317 20 as as IN cord-313694-p2sgaypq 317 21 been be VBN cord-313694-p2sgaypq 317 22 suggested suggest VBN cord-313694-p2sgaypq 317 23 for for IN cord-313694-p2sgaypq 317 24 , , , cord-313694-p2sgaypq 317 25 e.g. e.g. RB cord-313694-p2sgaypq 317 26 , , , cord-313694-p2sgaypq 317 27 binding bind VBG cord-313694-p2sgaypq 317 28 of of IN cord-313694-p2sgaypq 317 29 human human JJ cord-313694-p2sgaypq 317 30 chorionic chorionic JJ cord-313694-p2sgaypq 317 31 gonadotropin gonadotropin NN cord-313694-p2sgaypq 317 32 ( ( -LRB- cord-313694-p2sgaypq 317 33 71 71 CD cord-313694-p2sgaypq 317 34 ) ) -RRB- cord-313694-p2sgaypq 317 35 ( ( -LRB- cord-313694-p2sgaypq 317 36 72 72 CD cord-313694-p2sgaypq 317 37 ) ) -RRB- cord-313694-p2sgaypq 317 38 ( ( -LRB- cord-313694-p2sgaypq 317 39 73 73 CD cord-313694-p2sgaypq 317 40 ) ) -RRB- cord-313694-p2sgaypq 317 41 . . . cord-313694-p2sgaypq 318 1 This this DT cord-313694-p2sgaypq 318 2 hormone hormone NN cord-313694-p2sgaypq 318 3 does do VBZ cord-313694-p2sgaypq 318 4 not not RB cord-313694-p2sgaypq 318 5 depend depend VB cord-313694-p2sgaypq 318 6 upon upon IN cord-313694-p2sgaypq 318 7 its -PRON- PRP$ cord-313694-p2sgaypq 318 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 318 9 for for IN cord-313694-p2sgaypq 318 10 binding bind VBG cord-313694-p2sgaypq 318 11 to to IN cord-313694-p2sgaypq 318 12 its -PRON- PRP$ cord-313694-p2sgaypq 318 13 receptor receptor NN cord-313694-p2sgaypq 318 14 but but CC cord-313694-p2sgaypq 318 15 the the DT cord-313694-p2sgaypq 318 16 carbohydrate carbohydrate NN cord-313694-p2sgaypq 318 17 is be VBZ cord-313694-p2sgaypq 318 18 important important JJ cord-313694-p2sgaypq 318 19 for for IN cord-313694-p2sgaypq 318 20 activating activate VBG cord-313694-p2sgaypq 318 21 the the DT cord-313694-p2sgaypq 318 22 cellular cellular JJ cord-313694-p2sgaypq 318 23 response response NN cord-313694-p2sgaypq 318 24 . . . cord-313694-p2sgaypq 319 1 The the DT cord-313694-p2sgaypq 319 2 selected select VBN cord-313694-p2sgaypq 319 3 examples example NNS cord-313694-p2sgaypq 319 4 discussed discuss VBN cord-313694-p2sgaypq 319 5 here here RB cord-313694-p2sgaypq 319 6 indicate indicate VBP cord-313694-p2sgaypq 319 7 that that IN cord-313694-p2sgaypq 319 8 protein protein NN cord-313694-p2sgaypq 319 9 - - HYPH cord-313694-p2sgaypq 319 10 linked link VBN cord-313694-p2sgaypq 319 11 ( ( -LRB- cord-313694-p2sgaypq 319 12 or or CC cord-313694-p2sgaypq 319 13 possibly possibly RB cord-313694-p2sgaypq 319 14 lipid lipid NN cord-313694-p2sgaypq 319 15 - - HYPH cord-313694-p2sgaypq 319 16 linked link VBN cord-313694-p2sgaypq 319 17 ) ) -RRB- cord-313694-p2sgaypq 319 18 carbohydrate carbohydrate NN cord-313694-p2sgaypq 319 19 may may MD cord-313694-p2sgaypq 319 20 play play VB cord-313694-p2sgaypq 319 21 a a DT cord-313694-p2sgaypq 319 22 fundamental fundamental JJ cord-313694-p2sgaypq 319 23 role role NN cord-313694-p2sgaypq 319 24 in in IN cord-313694-p2sgaypq 319 25 multicellular multicellular JJ cord-313694-p2sgaypq 319 26 organization organization NN cord-313694-p2sgaypq 319 27 in in IN cord-313694-p2sgaypq 319 28 a a DT cord-313694-p2sgaypq 319 29 wide wide JJ cord-313694-p2sgaypq 319 30 phylogenetic phylogenetic JJ cord-313694-p2sgaypq 319 31 range range NN cord-313694-p2sgaypq 319 32 of of IN cord-313694-p2sgaypq 319 33 organisms organism NNS cord-313694-p2sgaypq 319 34 . . . cord-313694-p2sgaypq 320 1 Though though IN cord-313694-p2sgaypq 320 2 in in IN cord-313694-p2sgaypq 320 3 all all DT cord-313694-p2sgaypq 320 4 of of IN cord-313694-p2sgaypq 320 5 the the DT cord-313694-p2sgaypq 320 6 examples example NNS cord-313694-p2sgaypq 320 7 cited cite VBN cord-313694-p2sgaypq 320 8 there there EX cord-313694-p2sgaypq 320 9 is be VBZ cord-313694-p2sgaypq 320 10 a a DT cord-313694-p2sgaypq 320 11 specificity specificity NN cord-313694-p2sgaypq 320 12 in in IN cord-313694-p2sgaypq 320 13 the the DT cord-313694-p2sgaypq 320 14 adhesion adhesion NN cord-313694-p2sgaypq 320 15 , , , cord-313694-p2sgaypq 320 16 in in IN cord-313694-p2sgaypq 320 17 some some DT cord-313694-p2sgaypq 320 18 cases case NNS cord-313694-p2sgaypq 320 19 this this DT cord-313694-p2sgaypq 320 20 is be VBZ cord-313694-p2sgaypq 320 21 due due JJ cord-313694-p2sgaypq 320 22 to to IN cord-313694-p2sgaypq 320 23 multiple multiple JJ cord-313694-p2sgaypq 320 24 possibly possibly RB cord-313694-p2sgaypq 320 25 low low JJ cord-313694-p2sgaypq 320 26 - - HYPH cord-313694-p2sgaypq 320 27 affinity affinity NN cord-313694-p2sgaypq 320 28 binding bind VBG cord-313694-p2sgaypq 320 29 interactions interaction NNS cord-313694-p2sgaypq 320 30 . . . cord-313694-p2sgaypq 321 1 In in IN cord-313694-p2sgaypq 321 2 the the DT cord-313694-p2sgaypq 321 3 extreme extreme NN cord-313694-p2sgaypq 321 4 , , , cord-313694-p2sgaypq 321 5 each each DT cord-313694-p2sgaypq 321 6 single single JJ cord-313694-p2sgaypq 321 7 binding binding NN cord-313694-p2sgaypq 321 8 event event NN cord-313694-p2sgaypq 321 9 may may MD cord-313694-p2sgaypq 321 10 approach approach VB cord-313694-p2sgaypq 321 11 non non JJ cord-313694-p2sgaypq 321 12 - - JJ cord-313694-p2sgaypq 321 13 specificity specificity JJ cord-313694-p2sgaypq 321 14 , , , cord-313694-p2sgaypq 321 15 with with IN cord-313694-p2sgaypq 321 16 specificity specificity NN cord-313694-p2sgaypq 321 17 accruing accrue VBG cord-313694-p2sgaypq 321 18 through through IN cord-313694-p2sgaypq 321 19 multivalency multivalency NN cord-313694-p2sgaypq 321 20 . . . cord-313694-p2sgaypq 322 1 Perhaps perhaps RB cord-313694-p2sgaypq 322 2 this this DT cord-313694-p2sgaypq 322 3 implies imply VBZ cord-313694-p2sgaypq 322 4 that that IN cord-313694-p2sgaypq 322 5 the the DT cord-313694-p2sgaypq 322 6 formalization formalization NN cord-313694-p2sgaypq 322 7 of of IN cord-313694-p2sgaypq 322 8 non non JJ cord-313694-p2sgaypq 322 9 - - JJ cord-313694-p2sgaypq 322 10 specific specific JJ cord-313694-p2sgaypq 322 11 carbohydrate carbohydrate NN cord-313694-p2sgaypq 322 12 - - HYPH cord-313694-p2sgaypq 322 13 mediated mediate VBN cord-313694-p2sgaypq 322 14 events event NNS cord-313694-p2sgaypq 322 15 obscures obscure VBZ cord-313694-p2sgaypq 322 16 an an DT cord-313694-p2sgaypq 322 17 actual actual JJ cord-313694-p2sgaypq 322 18 continuum continuum NN cord-313694-p2sgaypq 322 19 of of IN cord-313694-p2sgaypq 322 20 specificity specificity NN cord-313694-p2sgaypq 322 21 in in IN cord-313694-p2sgaypq 322 22 these these DT cord-313694-p2sgaypq 322 23 events event NNS cord-313694-p2sgaypq 322 24 between between IN cord-313694-p2sgaypq 322 25 these these DT cord-313694-p2sgaypq 322 26 two two CD cord-313694-p2sgaypq 322 27 extremes extreme NNS cord-313694-p2sgaypq 322 28 . . . cord-313694-p2sgaypq 323 1 It -PRON- PRP cord-313694-p2sgaypq 323 2 is be VBZ cord-313694-p2sgaypq 323 3 unclear unclear JJ cord-313694-p2sgaypq 323 4 whether whether IN cord-313694-p2sgaypq 323 5 the the DT cord-313694-p2sgaypq 323 6 involvement involvement NN cord-313694-p2sgaypq 323 7 of of IN cord-313694-p2sgaypq 323 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 323 9 in in IN cord-313694-p2sgaypq 323 10 adhesion adhesion NN cord-313694-p2sgaypq 323 11 is be VBZ cord-313694-p2sgaypq 323 12 universal universal JJ cord-313694-p2sgaypq 323 13 . . . cord-313694-p2sgaypq 324 1 Several several JJ cord-313694-p2sgaypq 324 2 other other JJ cord-313694-p2sgaypq 324 3 adhesion adhesion NN cord-313694-p2sgaypq 324 4 molecules molecule NNS cord-313694-p2sgaypq 324 5 , , , cord-313694-p2sgaypq 324 6 including include VBG cord-313694-p2sgaypq 324 7 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 324 8 such such JJ cord-313694-p2sgaypq 324 9 as as IN cord-313694-p2sgaypq 324 10 gp80 gp80 NNP cord-313694-p2sgaypq 324 11 in in IN cord-313694-p2sgaypq 324 12 D. D. NNP cord-313694-p2sgaypq 324 13 discoideurn discoideurn NNP cord-313694-p2sgaypq 324 14 ( ( -LRB- cord-313694-p2sgaypq 324 15 164 164 CD cord-313694-p2sgaypq 324 16 ) ) -RRB- cord-313694-p2sgaypq 324 17 , , , cord-313694-p2sgaypq 324 18 CAM CAM NNP cord-313694-p2sgaypq 324 19 80/120 80/120 CD cord-313694-p2sgaypq 324 20 in in IN cord-313694-p2sgaypq 324 21 mammalian mammalian JJ cord-313694-p2sgaypq 324 22 cells cell NNS cord-313694-p2sgaypq 324 23 , , , cord-313694-p2sgaypq 324 24 etc etc FW cord-313694-p2sgaypq 324 25 . . . cord-313694-p2sgaypq 325 1 and and CC cord-313694-p2sgaypq 325 2 glycolipids glycolipid NNS cord-313694-p2sgaypq 325 3 ( ( -LRB- cord-313694-p2sgaypq 325 4 146 146 CD cord-313694-p2sgaypq 325 5 ) ) -RRB- cord-313694-p2sgaypq 325 6 , , , cord-313694-p2sgaypq 325 7 are be VBP cord-313694-p2sgaypq 325 8 glycosylated glycosylate VBN cord-313694-p2sgaypq 325 9 but but CC cord-313694-p2sgaypq 325 10 the the DT cord-313694-p2sgaypq 325 11 role role NN cord-313694-p2sgaypq 325 12 of of IN cord-313694-p2sgaypq 325 13 carbohydrate carbohydrate NN cord-313694-p2sgaypq 325 14 is be VBZ cord-313694-p2sgaypq 325 15 not not RB cord-313694-p2sgaypq 325 16 known know VBN cord-313694-p2sgaypq 325 17 . . . cord-313694-p2sgaypq 326 1 If if IN cord-313694-p2sgaypq 326 2 the the DT cord-313694-p2sgaypq 326 3 use use NN cord-313694-p2sgaypq 326 4 of of IN cord-313694-p2sgaypq 326 5 carbohydrate carbohydrate NN cord-313694-p2sgaypq 326 6 is be VBZ cord-313694-p2sgaypq 326 7 universal universal JJ cord-313694-p2sgaypq 326 8 , , , cord-313694-p2sgaypq 326 9 then then RB cord-313694-p2sgaypq 326 10 the the DT cord-313694-p2sgaypq 326 11 specificity specificity NN cord-313694-p2sgaypq 326 12 inherent inherent JJ cord-313694-p2sgaypq 326 13 in in IN cord-313694-p2sgaypq 326 14 the the DT cord-313694-p2sgaypq 326 15 examples example NNS cord-313694-p2sgaypq 326 16 discussed discuss VBN cord-313694-p2sgaypq 326 17 would would MD cord-313694-p2sgaypq 326 18 suggest suggest VB cord-313694-p2sgaypq 326 19 an an DT cord-313694-p2sgaypq 326 20 underlying underlie VBG cord-313694-p2sgaypq 326 21 structural structural JJ cord-313694-p2sgaypq 326 22 code code NN cord-313694-p2sgaypq 326 23 which which WDT cord-313694-p2sgaypq 326 24 may may MD cord-313694-p2sgaypq 326 25 be be VB cord-313694-p2sgaypq 326 26 important important JJ cord-313694-p2sgaypq 326 27 for for IN cord-313694-p2sgaypq 326 28 the the DT cord-313694-p2sgaypq 326 29 affiliated affiliate VBN cord-313694-p2sgaypq 326 30 processes process NNS cord-313694-p2sgaypq 326 31 of of IN cord-313694-p2sgaypq 326 32 cell cell NN cord-313694-p2sgaypq 326 33 sorting sorting NN cord-313694-p2sgaypq 326 34 and and CC cord-313694-p2sgaypq 326 35 morphogenesis morphogenesis NN cord-313694-p2sgaypq 326 36 , , , cord-313694-p2sgaypq 326 37 to to TO cord-313694-p2sgaypq 326 38 which which WDT cord-313694-p2sgaypq 326 39 adhesion adhesion NN cord-313694-p2sgaypq 326 40 makes make VBZ cord-313694-p2sgaypq 326 41 a a DT cord-313694-p2sgaypq 326 42 very very RB cord-313694-p2sgaypq 326 43 important important JJ cord-313694-p2sgaypq 326 44 contribution contribution NN cord-313694-p2sgaypq 326 45 . . . cord-313694-p2sgaypq 327 1 This this DT cord-313694-p2sgaypq 327 2 may may MD cord-313694-p2sgaypq 327 3 explain explain VB cord-313694-p2sgaypq 327 4 some some DT cord-313694-p2sgaypq 327 5 of of IN cord-313694-p2sgaypq 327 6 the the DT cord-313694-p2sgaypq 327 7 interesting interesting JJ cord-313694-p2sgaypq 327 8 morphogenetic morphogenetic JJ cord-313694-p2sgaypq 327 9 effects effect NNS cord-313694-p2sgaypq 327 10 circumstantially circumstantially RB cord-313694-p2sgaypq 327 11 suggested suggest VBN cord-313694-p2sgaypq 327 12 by by IN cord-313694-p2sgaypq 327 13 many many JJ cord-313694-p2sgaypq 327 14 studies study NNS cord-313694-p2sgaypq 327 15 involving involve VBG cord-313694-p2sgaypq 327 16 carbohydrate carbohydrate NN cord-313694-p2sgaypq 327 17 structure structure NN cord-313694-p2sgaypq 327 18 perturbations perturbation NNS cord-313694-p2sgaypq 327 19 on on IN cord-313694-p2sgaypq 327 20 developing develop VBG cord-313694-p2sgaypq 327 21 cells cell NNS cord-313694-p2sgaypq 327 22 . . . cord-313694-p2sgaypq 328 1 A a DT cord-313694-p2sgaypq 328 2 role role NN cord-313694-p2sgaypq 328 3 for for IN cord-313694-p2sgaypq 328 4 carbohydrate carbohydrate NN cord-313694-p2sgaypq 328 5 in in IN cord-313694-p2sgaypq 328 6 cell cell NN cord-313694-p2sgaypq 328 7 adhesion adhesion NN cord-313694-p2sgaypq 328 8 choice choice NN cord-313694-p2sgaypq 328 9 or or CC cord-313694-p2sgaypq 328 10 sorting sorting NN cord-313694-p2sgaypq 328 11 correlates correlate VBZ cord-313694-p2sgaypq 328 12 with with IN cord-313694-p2sgaypq 328 13 its -PRON- PRP$ cord-313694-p2sgaypq 328 14 postulated postulate VBN cord-313694-p2sgaypq 328 15 role role NN cord-313694-p2sgaypq 328 16 in in IN cord-313694-p2sgaypq 328 17 intracellular intracellular JJ cord-313694-p2sgaypq 328 18 or or CC cord-313694-p2sgaypq 328 19 extracellular extracellular JJ cord-313694-p2sgaypq 328 20 compartmentalization compartmentalization NN cord-313694-p2sgaypq 328 21 of of IN cord-313694-p2sgaypq 328 22 proteins protein NNS cord-313694-p2sgaypq 328 23 . . . cord-313694-p2sgaypq 329 1 Cell cell NN cord-313694-p2sgaypq 329 2 sorting sorting NN cord-313694-p2sgaypq 329 3 and and CC cord-313694-p2sgaypq 329 4 molecular molecular JJ cord-313694-p2sgaypq 329 5 compartmentalization compartmentalization NN cord-313694-p2sgaypq 329 6 can can MD cord-313694-p2sgaypq 329 7 be be VB cord-313694-p2sgaypq 329 8 regarded regard VBN cord-313694-p2sgaypq 329 9 as as IN cord-313694-p2sgaypq 329 10 sorting sort VBG cord-313694-p2sgaypq 329 11 at at IN cord-313694-p2sgaypq 329 12 different different JJ cord-313694-p2sgaypq 329 13 levels level NNS cord-313694-p2sgaypq 329 14 . . . cord-313694-p2sgaypq 330 1 It -PRON- PRP cord-313694-p2sgaypq 330 2 will will MD cord-313694-p2sgaypq 330 3 be be VB cord-313694-p2sgaypq 330 4 interesting interesting JJ cord-313694-p2sgaypq 330 5 to to TO cord-313694-p2sgaypq 330 6 learn learn VB cord-313694-p2sgaypq 330 7 whether whether IN cord-313694-p2sgaypq 330 8 the the DT cord-313694-p2sgaypq 330 9 proteins protein NNS cord-313694-p2sgaypq 330 10 on on IN cord-313694-p2sgaypq 330 11 which which WDT cord-313694-p2sgaypq 330 12 these these DT cord-313694-p2sgaypq 330 13 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 330 14 are be VBP cord-313694-p2sgaypq 330 15 located locate VBN cord-313694-p2sgaypq 330 16 exist exist VBP cord-313694-p2sgaypq 330 17 only only RB cord-313694-p2sgaypq 330 18 to to TO cord-313694-p2sgaypq 330 19 place place VB cord-313694-p2sgaypq 330 20 the the DT cord-313694-p2sgaypq 330 21 carbohydrate carbohydrate NN cord-313694-p2sgaypq 330 22 or or CC cord-313694-p2sgaypq 330 23 whether whether IN cord-313694-p2sgaypq 330 24 the the DT cord-313694-p2sgaypq 330 25 carbohydrate carbohydrate NN cord-313694-p2sgaypq 330 26 piggybacks piggyback VBZ cord-313694-p2sgaypq 330 27 on on IN cord-313694-p2sgaypq 330 28 another another DT cord-313694-p2sgaypq 330 29 essential essential JJ cord-313694-p2sgaypq 330 30 function function NN cord-313694-p2sgaypq 330 31 of of IN cord-313694-p2sgaypq 330 32 the the DT cord-313694-p2sgaypq 330 33 protein protein NN cord-313694-p2sgaypq 330 34 . . . cord-313694-p2sgaypq 331 1 Were be VBD cord-313694-p2sgaypq 331 2 the the DT cord-313694-p2sgaypq 331 3 latter latter JJ cord-313694-p2sgaypq 331 4 true true JJ cord-313694-p2sgaypq 331 5 , , , cord-313694-p2sgaypq 331 6 this this DT cord-313694-p2sgaypq 331 7 would would MD cord-313694-p2sgaypq 331 8 strengthen strengthen VB cord-313694-p2sgaypq 331 9 the the DT cord-313694-p2sgaypq 331 10 analogy analogy NN cord-313694-p2sgaypq 331 11 with with IN cord-313694-p2sgaypq 331 12 the the DT cord-313694-p2sgaypq 331 13 role role NN cord-313694-p2sgaypq 331 14 of of IN cord-313694-p2sgaypq 331 15 carbohydrate carbohydrate NN cord-313694-p2sgaypq 331 16 in in IN cord-313694-p2sgaypq 331 17 routing route VBG cord-313694-p2sgaypq 331 18 or or CC cord-313694-p2sgaypq 331 19 molecular molecular JJ cord-313694-p2sgaypq 331 20 compartmentalization compartmentalization NN cord-313694-p2sgaypq 331 21 . . . cord-313694-p2sgaypq 332 1 It -PRON- PRP cord-313694-p2sgaypq 332 2 may may MD cord-313694-p2sgaypq 332 3 then then RB cord-313694-p2sgaypq 332 4 become become VB cord-313694-p2sgaypq 332 5 feasible feasible JJ cord-313694-p2sgaypq 332 6 to to TO cord-313694-p2sgaypq 332 7 generalize generalize VB cord-313694-p2sgaypq 332 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 332 9 's 's POS cord-313694-p2sgaypq 332 10 role role NN cord-313694-p2sgaypq 332 11 as as IN cord-313694-p2sgaypq 332 12 important important JJ cord-313694-p2sgaypq 332 13 for for IN cord-313694-p2sgaypq 332 14 the the DT cord-313694-p2sgaypq 332 15 three three CD cord-313694-p2sgaypq 332 16 - - HYPH cord-313694-p2sgaypq 332 17 dimensional dimensional JJ cord-313694-p2sgaypq 332 18 compartmentalization compartmentalization NN cord-313694-p2sgaypq 332 19 of of IN cord-313694-p2sgaypq 332 20 proteins protein NNS cord-313694-p2sgaypq 332 21 , , , cord-313694-p2sgaypq 332 22 and and CC cord-313694-p2sgaypq 332 23 the the DT cord-313694-p2sgaypq 332 24 cells cell NNS cord-313694-p2sgaypq 332 25 , , , cord-313694-p2sgaypq 332 26 with with IN cord-313694-p2sgaypq 332 27 which which WDT cord-313694-p2sgaypq 332 28 they -PRON- PRP cord-313694-p2sgaypq 332 29 are be VBP cord-313694-p2sgaypq 332 30 associated associate VBN cord-313694-p2sgaypq 332 31 . . . cord-313694-p2sgaypq 333 1 As as IN cord-313694-p2sgaypq 333 2 such such JJ cord-313694-p2sgaypq 333 3 , , , cord-313694-p2sgaypq 333 4 carbohydrate carbohydrate NN cord-313694-p2sgaypq 333 5 may may MD cord-313694-p2sgaypq 333 6 be be VB cord-313694-p2sgaypq 333 7 the the DT cord-313694-p2sgaypq 333 8 chemical chemical NN cord-313694-p2sgaypq 333 9 structure structure NN cord-313694-p2sgaypq 333 10 cells cell NNS cord-313694-p2sgaypq 333 11 used use VBN cord-313694-p2sgaypq 333 12 to to TO cord-313694-p2sgaypq 333 13 address address VB cord-313694-p2sgaypq 333 14 and and CC cord-313694-p2sgaypq 333 15 organize organize VB cord-313694-p2sgaypq 333 16 space space NN cord-313694-p2sgaypq 333 17 as as IN cord-313694-p2sgaypq 333 18 they -PRON- PRP cord-313694-p2sgaypq 333 19 evolved evolve VBD cord-313694-p2sgaypq 333 20 from from IN cord-313694-p2sgaypq 333 21 prokaryotes prokaryote NNS cord-313694-p2sgaypq 333 22 to to IN cord-313694-p2sgaypq 333 23 unicellular unicellular JJ cord-313694-p2sgaypq 333 24 eukaryotes eukaryote NNS cord-313694-p2sgaypq 333 25 , , , cord-313694-p2sgaypq 333 26 and and CC cord-313694-p2sgaypq 333 27 continued continue VBD cord-313694-p2sgaypq 333 28 to to TO cord-313694-p2sgaypq 333 29 exploit exploit VB cord-313694-p2sgaypq 333 30 as as IN cord-313694-p2sgaypq 333 31 they -PRON- PRP cord-313694-p2sgaypq 333 32 evolved evolve VBD cord-313694-p2sgaypq 333 33 to to TO cord-313694-p2sgaypq 333 34 form form VB cord-313694-p2sgaypq 333 35 multicellular multicellular JJ cord-313694-p2sgaypq 333 36 tissues tissue NNS cord-313694-p2sgaypq 333 37 and and CC cord-313694-p2sgaypq 333 38 organs organ NNS cord-313694-p2sgaypq 333 39 . . . cord-313694-p2sgaypq 334 1 Numerous numerous JJ cord-313694-p2sgaypq 334 2 studies study NNS cord-313694-p2sgaypq 334 3 have have VBP cord-313694-p2sgaypq 334 4 implicated implicate VBN cord-313694-p2sgaypq 334 5 protein protein NN cord-313694-p2sgaypq 334 6 - - HYPH cord-313694-p2sgaypq 334 7 linked link VBN cord-313694-p2sgaypq 334 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 334 9 in in IN cord-313694-p2sgaypq 334 10 more more RBR cord-313694-p2sgaypq 334 11 complicated complicated JJ cord-313694-p2sgaypq 334 12 cellular cellular JJ cord-313694-p2sgaypq 334 13 phenomena phenomenon NNS cord-313694-p2sgaypq 334 14 ( ( -LRB- cord-313694-p2sgaypq 334 15 43 43 CD cord-313694-p2sgaypq 334 16 , , , cord-313694-p2sgaypq 334 17 122 122 CD cord-313694-p2sgaypq 334 18 ) ) -RRB- cord-313694-p2sgaypq 334 19 . . . cord-313694-p2sgaypq 335 1 Glycosylation Glycosylation NNP cord-313694-p2sgaypq 335 2 is be VBZ cord-313694-p2sgaypq 335 3 modulated modulate VBN cord-313694-p2sgaypq 335 4 coincidentally coincidentally RB cord-313694-p2sgaypq 335 5 with with IN cord-313694-p2sgaypq 335 6 numerous numerous JJ cord-313694-p2sgaypq 335 7 developmental developmental JJ cord-313694-p2sgaypq 335 8 processes process NNS cord-313694-p2sgaypq 335 9 ( ( -LRB- cord-313694-p2sgaypq 335 10 122 122 CD cord-313694-p2sgaypq 335 11 , , , cord-313694-p2sgaypq 335 12 53 53 CD cord-313694-p2sgaypq 335 13 - - SYM cord-313694-p2sgaypq 335 14 67 67 CD cord-313694-p2sgaypq 335 15 , , , cord-313694-p2sgaypq 335 16 69 69 CD cord-313694-p2sgaypq 335 17 , , , cord-313694-p2sgaypq 335 18 96 96 CD cord-313694-p2sgaypq 335 19 , , , cord-313694-p2sgaypq 335 20 161 161 CD cord-313694-p2sgaypq 335 21 ) ) -RRB- cord-313694-p2sgaypq 335 22 . . . cord-313694-p2sgaypq 336 1 Carbohydrate carbohydrate NN cord-313694-p2sgaypq 336 2 interactions interaction NNS cord-313694-p2sgaypq 336 3 have have VBP cord-313694-p2sgaypq 336 4 been be VBN cord-313694-p2sgaypq 336 5 implicated implicate VBN cord-313694-p2sgaypq 336 6 in in IN cord-313694-p2sgaypq 336 7 mammalian mammalian JJ cord-313694-p2sgaypq 336 8 morula morula NN cord-313694-p2sgaypq 336 9 compaction compaction NN cord-313694-p2sgaypq 336 10 ( ( -LRB- cord-313694-p2sgaypq 336 11 131 131 CD cord-313694-p2sgaypq 336 12 , , , cord-313694-p2sgaypq 336 13 122 122 CD cord-313694-p2sgaypq 336 14 , , , cord-313694-p2sgaypq 336 15 123 123 CD cord-313694-p2sgaypq 336 16 ) ) -RRB- cord-313694-p2sgaypq 336 17 . . . cord-313694-p2sgaypq 337 1 Proliferation proliferation NN cord-313694-p2sgaypq 337 2 has have VBZ cord-313694-p2sgaypq 337 3 been be VBN cord-313694-p2sgaypq 337 4 reported report VBN cord-313694-p2sgaypq 337 5 to to TO cord-313694-p2sgaypq 337 6 require require VB cord-313694-p2sgaypq 337 7 glycosylation glycosylation NN cord-313694-p2sgaypq 337 8 ( ( -LRB- cord-313694-p2sgaypq 337 9 41 41 CD cord-313694-p2sgaypq 337 10 ) ) -RRB- cord-313694-p2sgaypq 337 11 or or CC cord-313694-p2sgaypq 337 12 to to TO cord-313694-p2sgaypq 337 13 be be VB cord-313694-p2sgaypq 337 14 inhibited inhibit VBN cord-313694-p2sgaypq 337 15 by by IN cord-313694-p2sgaypq 337 16 glycopeptides glycopeptide NNS cord-313694-p2sgaypq 337 17 and and CC cord-313694-p2sgaypq 337 18 a a DT cord-313694-p2sgaypq 337 19 defined define VBN cord-313694-p2sgaypq 337 20 fragment fragment NN cord-313694-p2sgaypq 337 21 of of IN cord-313694-p2sgaypq 337 22 heparan heparan JJ cord-313694-p2sgaypq 337 23 sulfate sulfate NN cord-313694-p2sgaypq 337 24 ( ( -LRB- cord-313694-p2sgaypq 337 25 143 143 CD cord-313694-p2sgaypq 337 26 , , , cord-313694-p2sgaypq 337 27 151 151 CD cord-313694-p2sgaypq 337 28 ) ) -RRB- cord-313694-p2sgaypq 337 29 . . . cord-313694-p2sgaypq 338 1 Oligosaccharides Oligosaccharides NNP cord-313694-p2sgaypq 338 2 released release VBD cord-313694-p2sgaypq 338 3 from from IN cord-313694-p2sgaypq 338 4 plant plant NN cord-313694-p2sgaypq 338 5 cell cell NN cord-313694-p2sgaypq 338 6 walls wall NNS cord-313694-p2sgaypq 338 7 can can MD cord-313694-p2sgaypq 338 8 stimulate stimulate VB cord-313694-p2sgaypq 338 9 cell cell NN cord-313694-p2sgaypq 338 10 proliferation proliferation NN cord-313694-p2sgaypq 338 11 and and CC cord-313694-p2sgaypq 338 12 alter alter VB cord-313694-p2sgaypq 338 13 cell cell NN cord-313694-p2sgaypq 338 14 differentiation differentiation NN cord-313694-p2sgaypq 338 15 in in IN cord-313694-p2sgaypq 338 16 plant plant NN cord-313694-p2sgaypq 338 17 cells cell NNS cord-313694-p2sgaypq 338 18 ( ( -LRB- cord-313694-p2sgaypq 338 19 145 145 CD cord-313694-p2sgaypq 338 20 ) ) -RRB- cord-313694-p2sgaypq 338 21 . . . cord-313694-p2sgaypq 339 1 Myogenesis Myogenesis NNP cord-313694-p2sgaypq 339 2 and and CC cord-313694-p2sgaypq 339 3 chondrogenesis chondrogenesis NNP cord-313694-p2sgaypq 339 4 have have VBP cord-313694-p2sgaypq 339 5 been be VBN cord-313694-p2sgaypq 339 6 speculated speculate VBN cord-313694-p2sgaypq 339 7 to to TO cord-313694-p2sgaypq 339 8 be be VB cord-313694-p2sgaypq 339 9 affected affect VBN cord-313694-p2sgaypq 339 10 by by IN cord-313694-p2sgaypq 339 11 GAGs gag NNS cord-313694-p2sgaypq 339 12 linked link VBN cord-313694-p2sgaypq 339 13 to to IN cord-313694-p2sgaypq 339 14 proteoglycans proteoglycan NNS cord-313694-p2sgaypq 339 15 ( ( -LRB- cord-313694-p2sgaypq 339 16 e.g. e.g. RB cord-313694-p2sgaypq 339 17 , , , cord-313694-p2sgaypq 339 18 113 113 CD cord-313694-p2sgaypq 339 19 ) ) -RRB- cord-313694-p2sgaypq 339 20 , , , cord-313694-p2sgaypq 339 21 but but CC cord-313694-p2sgaypq 339 22 conclusions conclusion NNS cord-313694-p2sgaypq 339 23 in in IN cord-313694-p2sgaypq 339 24 this this DT cord-313694-p2sgaypq 339 25 field field NN cord-313694-p2sgaypq 339 26 are be VBP cord-313694-p2sgaypq 339 27 very very RB cord-313694-p2sgaypq 339 28 controversial controversial JJ cord-313694-p2sgaypq 339 29 . . . cord-313694-p2sgaypq 340 1 Attachment attachment NN cord-313694-p2sgaypq 340 2 of of IN cord-313694-p2sgaypq 340 3 cells cell NNS cord-313694-p2sgaypq 340 4 to to IN cord-313694-p2sgaypq 340 5 substratum substratum NN cord-313694-p2sgaypq 340 6 - - HYPH cord-313694-p2sgaypq 340 7 associated associate VBN cord-313694-p2sgaypq 340 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 340 9 can can MD cord-313694-p2sgaypq 340 10 result result VB cord-313694-p2sgaypq 340 11 in in IN cord-313694-p2sgaypq 340 12 its -PRON- PRP$ cord-313694-p2sgaypq 340 13 covalent covalent JJ cord-313694-p2sgaypq 340 14 modification modification NN cord-313694-p2sgaypq 340 15 ( ( -LRB- cord-313694-p2sgaypq 340 16 213 213 CD cord-313694-p2sgaypq 340 17 , , , cord-313694-p2sgaypq 340 18 130 130 CD cord-313694-p2sgaypq 340 19 ) ) -RRB- cord-313694-p2sgaypq 340 20 . . . cord-313694-p2sgaypq 341 1 Neuritogenesis Neuritogenesis NNP cord-313694-p2sgaypq 341 2 has have VBZ cord-313694-p2sgaypq 341 3 been be VBN cord-313694-p2sgaypq 341 4 shown show VBN cord-313694-p2sgaypq 341 5 to to TO cord-313694-p2sgaypq 341 6 be be VB cord-313694-p2sgaypq 341 7 inhibited inhibit VBN cord-313694-p2sgaypq 341 8 in in IN cord-313694-p2sgaypq 341 9 vitro vitro FW cord-313694-p2sgaypq 341 10 by by IN cord-313694-p2sgaypq 341 11 tunicamycin tunicamycin NNS cord-313694-p2sgaypq 341 12 ( ( -LRB- cord-313694-p2sgaypq 341 13 16 16 CD cord-313694-p2sgaypq 341 14 ) ) -RRB- cord-313694-p2sgaypq 341 15 , , , cord-313694-p2sgaypq 341 16 though though IN cord-313694-p2sgaypq 341 17 the the DT cord-313694-p2sgaypq 341 18 specificity specificity NN cord-313694-p2sgaypq 341 19 of of IN cord-313694-p2sgaypq 341 20 the the DT cord-313694-p2sgaypq 341 21 effect effect NN cord-313694-p2sgaypq 341 22 is be VBZ cord-313694-p2sgaypq 341 23 difficult difficult JJ cord-313694-p2sgaypq 341 24 to to TO cord-313694-p2sgaypq 341 25 assess assess VB cord-313694-p2sgaypq 341 26 , , , cord-313694-p2sgaypq 341 27 as as IN cord-313694-p2sgaypq 341 28 tunicamycin tunicamycin NN cord-313694-p2sgaypq 341 29 - - HYPH cord-313694-p2sgaypq 341 30 sensitivity sensitivity NN cord-313694-p2sgaypq 341 31 does do VBZ cord-313694-p2sgaypq 341 32 not not RB cord-313694-p2sgaypq 341 33 convincingly convincingly RB cord-313694-p2sgaypq 341 34 demonstrate demonstrate VB cord-313694-p2sgaypq 341 35 the the DT cord-313694-p2sgaypq 341 36 involvement involvement NN cord-313694-p2sgaypq 341 37 of of IN cord-313694-p2sgaypq 341 38 protein protein NN cord-313694-p2sgaypq 341 39 - - HYPH cord-313694-p2sgaypq 341 40 linked link VBN cord-313694-p2sgaypq 341 41 carbohydrate carbohydrate NN cord-313694-p2sgaypq 341 42 ( ( -LRB- cord-313694-p2sgaypq 341 43 15 15 CD cord-313694-p2sgaypq 341 44 , , , cord-313694-p2sgaypq 341 45 17 17 CD cord-313694-p2sgaypq 341 46 ) ) -RRB- cord-313694-p2sgaypq 341 47 . . . cord-313694-p2sgaypq 342 1 A a DT cord-313694-p2sgaypq 342 2 recent recent JJ cord-313694-p2sgaypq 342 3 report report NN cord-313694-p2sgaypq 342 4 suggests suggest VBZ cord-313694-p2sgaypq 342 5 that that IN cord-313694-p2sgaypq 342 6 alteration alteration NN cord-313694-p2sgaypq 342 7 of of IN cord-313694-p2sgaypq 342 8 processing processing NN cord-313694-p2sgaypq 342 9 of of IN cord-313694-p2sgaypq 342 10 Nlinked Nlinked NNP cord-313694-p2sgaypq 342 11 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 342 12 with with IN cord-313694-p2sgaypq 342 13 swainsonine swainsonine NN cord-313694-p2sgaypq 342 14 , , , cord-313694-p2sgaypq 342 15 without without IN cord-313694-p2sgaypq 342 16 affecting affect VBG cord-313694-p2sgaypq 342 17 cell cell NN cord-313694-p2sgaypq 342 18 viablility viablility NN cord-313694-p2sgaypq 342 19 , , , cord-313694-p2sgaypq 342 20 inhibits inhibit VBZ cord-313694-p2sgaypq 342 21 the the DT cord-313694-p2sgaypq 342 22 ability ability NN cord-313694-p2sgaypq 342 23 of of IN cord-313694-p2sgaypq 342 24 a a DT cord-313694-p2sgaypq 342 25 line line NN cord-313694-p2sgaypq 342 26 of of IN cord-313694-p2sgaypq 342 27 melanoma melanoma NN cord-313694-p2sgaypq 342 28 cells cell NNS cord-313694-p2sgaypq 342 29 to to TO cord-313694-p2sgaypq 342 30 metastasize metastasize VB cord-313694-p2sgaypq 342 31 to to IN cord-313694-p2sgaypq 342 32 the the DT cord-313694-p2sgaypq 342 33 lung lung NN cord-313694-p2sgaypq 342 34 ( ( -LRB- cord-313694-p2sgaypq 342 35 52 52 CD cord-313694-p2sgaypq 342 36 ) ) -RRB- cord-313694-p2sgaypq 342 37 . . . cord-313694-p2sgaypq 343 1 This this DT cord-313694-p2sgaypq 343 2 finding finding NN cord-313694-p2sgaypq 343 3 is be VBZ cord-313694-p2sgaypq 343 4 consistent consistent JJ cord-313694-p2sgaypq 343 5 with with IN cord-313694-p2sgaypq 343 6 another another DT cord-313694-p2sgaypq 343 7 report report NN cord-313694-p2sgaypq 343 8 documenting document VBG cord-313694-p2sgaypq 343 9 carbohydrate carbohydrate NN cord-313694-p2sgaypq 343 10 differences difference NNS cord-313694-p2sgaypq 343 11 between between IN cord-313694-p2sgaypq 343 12 metastatic metastatic JJ cord-313694-p2sgaypq 343 13 and and CC cord-313694-p2sgaypq 343 14 non non JJ cord-313694-p2sgaypq 343 15 - - JJ cord-313694-p2sgaypq 343 16 metastatic metastatic JJ cord-313694-p2sgaypq 343 17 cell cell NN cord-313694-p2sgaypq 343 18 lines line NNS cord-313694-p2sgaypq 343 19 ( ( -LRB- cord-313694-p2sgaypq 343 20 49 49 CD cord-313694-p2sgaypq 343 21 ) ) -RRB- cord-313694-p2sgaypq 343 22 . . . cord-313694-p2sgaypq 344 1 There there EX cord-313694-p2sgaypq 344 2 is be VBZ cord-313694-p2sgaypq 344 3 much much JJ cord-313694-p2sgaypq 344 4 new new JJ cord-313694-p2sgaypq 344 5 territory territory NN cord-313694-p2sgaypq 344 6 to to TO cord-313694-p2sgaypq 344 7 explore explore VB cord-313694-p2sgaypq 344 8 in in IN cord-313694-p2sgaypq 344 9 the the DT cord-313694-p2sgaypq 344 10 field field NN cord-313694-p2sgaypq 344 11 . . . cord-313694-p2sgaypq 345 1 The the DT cord-313694-p2sgaypq 345 2 use use NN cord-313694-p2sgaypq 345 3 of of IN cord-313694-p2sgaypq 345 4 monoclonal monoclonal JJ cord-313694-p2sgaypq 345 5 antibodies antibody NNS cord-313694-p2sgaypq 345 6 and and CC cord-313694-p2sgaypq 345 7 lectins lectin NNS cord-313694-p2sgaypq 345 8 which which WDT cord-313694-p2sgaypq 345 9 recognize recognize VBP cord-313694-p2sgaypq 345 10 carbohydrate carbohydrate NN cord-313694-p2sgaypq 345 11 - - HYPH cord-313694-p2sgaypq 345 12 dependent dependent JJ cord-313694-p2sgaypq 345 13 epitopes epitope NNS cord-313694-p2sgaypq 345 14 continues continue VBZ cord-313694-p2sgaypq 345 15 to to TO cord-313694-p2sgaypq 345 16 reveal reveal VB cord-313694-p2sgaypq 345 17 an an DT cord-313694-p2sgaypq 345 18 unexpected unexpected JJ cord-313694-p2sgaypq 345 19 diversity diversity NN cord-313694-p2sgaypq 345 20 of of IN cord-313694-p2sgaypq 345 21 carbohydrate carbohydrate NN cord-313694-p2sgaypq 345 22 structures structure NNS cord-313694-p2sgaypq 345 23 with with IN cord-313694-p2sgaypq 345 24 surprisingly surprisingly RB cord-313694-p2sgaypq 345 25 intricate intricate JJ cord-313694-p2sgaypq 345 26 distributions distribution NNS cord-313694-p2sgaypq 345 27 in in IN cord-313694-p2sgaypq 345 28 embryonic embryonic JJ cord-313694-p2sgaypq 345 29 and and CC cord-313694-p2sgaypq 345 30 adult adult NN cord-313694-p2sgaypq 345 31 tissues tissue NNS cord-313694-p2sgaypq 345 32 . . . cord-313694-p2sgaypq 346 1 This this DT cord-313694-p2sgaypq 346 2 has have VBZ cord-313694-p2sgaypq 346 3 recently recently RB cord-313694-p2sgaypq 346 4 been be VBN cord-313694-p2sgaypq 346 5 appreciated appreciate VBN cord-313694-p2sgaypq 346 6 in in IN cord-313694-p2sgaypq 346 7 amphibian amphibian NN cord-313694-p2sgaypq 346 8 ( ( -LRB- cord-313694-p2sgaypq 346 9 53 53 CD cord-313694-p2sgaypq 346 10 ) ) -RRB- cord-313694-p2sgaypq 346 11 and and CC cord-313694-p2sgaypq 346 12 mouse mouse NN cord-313694-p2sgaypq 346 13 ( ( -LRB- cord-313694-p2sgaypq 346 14 54 54 CD cord-313694-p2sgaypq 346 15 , , , cord-313694-p2sgaypq 346 16 55 55 CD cord-313694-p2sgaypq 346 17 ) ) -RRB- cord-313694-p2sgaypq 346 18 embryos embryo NNS cord-313694-p2sgaypq 346 19 and and CC cord-313694-p2sgaypq 346 20 in in IN cord-313694-p2sgaypq 346 21 the the DT cord-313694-p2sgaypq 346 22 simpler simple JJR cord-313694-p2sgaypq 346 23 model model NN cord-313694-p2sgaypq 346 24 system system NN cord-313694-p2sgaypq 346 25 Dictyostelium Dictyostelium NNP cord-313694-p2sgaypq 346 26 discoideum discoideum NN cord-313694-p2sgaypq 346 27 ( ( -LRB- cord-313694-p2sgaypq 346 28 96 96 CD cord-313694-p2sgaypq 346 29 , , , cord-313694-p2sgaypq 346 30 161 161 CD cord-313694-p2sgaypq 346 31 ) ) -RRB- cord-313694-p2sgaypq 346 32 . . . cord-313694-p2sgaypq 347 1 Tumor tumor NN cord-313694-p2sgaypq 347 2 cells cell NNS cord-313694-p2sgaypq 347 3 also also RB cord-313694-p2sgaypq 347 4 differ differ VBP cord-313694-p2sgaypq 347 5 in in IN cord-313694-p2sgaypq 347 6 many many JJ cord-313694-p2sgaypq 347 7 cases case NNS cord-313694-p2sgaypq 347 8 in in IN cord-313694-p2sgaypq 347 9 specific specific JJ cord-313694-p2sgaypq 347 10 carbohydrate carbohydrate NN cord-313694-p2sgaypq 347 11 structures structure NNS cord-313694-p2sgaypq 347 12 on on IN cord-313694-p2sgaypq 347 13 both both CC cord-313694-p2sgaypq 347 14 lipid lipid NN cord-313694-p2sgaypq 347 15 and and CC cord-313694-p2sgaypq 347 16 protein protein NN cord-313694-p2sgaypq 347 17 ( ( -LRB- cord-313694-p2sgaypq 347 18 44 44 CD cord-313694-p2sgaypq 347 19 - - SYM cord-313694-p2sgaypq 347 20 46 46 CD cord-313694-p2sgaypq 347 21 , , , cord-313694-p2sgaypq 347 22 49 49 CD cord-313694-p2sgaypq 347 23 - - SYM cord-313694-p2sgaypq 347 24 51,180 51,180 CD cord-313694-p2sgaypq 347 25 ) ) -RRB- cord-313694-p2sgaypq 347 26 . . . cord-313694-p2sgaypq 348 1 Several several JJ cord-313694-p2sgaypq 348 2 of of IN cord-313694-p2sgaypq 348 3 the the DT cord-313694-p2sgaypq 348 4 antibodies antibody NNS cord-313694-p2sgaypq 348 5 employed employ VBN cord-313694-p2sgaypq 348 6 recognize recognize VBP cord-313694-p2sgaypq 348 7 carbohydrate carbohydrate NN cord-313694-p2sgaypq 348 8 epitopes epitope NNS cord-313694-p2sgaypq 348 9 whose whose WP$ cord-313694-p2sgaypq 348 10 corresponding correspond VBG cord-313694-p2sgaypq 348 11 structures structure NNS cord-313694-p2sgaypq 348 12 have have VBP cord-313694-p2sgaypq 348 13 been be VBN cord-313694-p2sgaypq 348 14 determined determine VBN cord-313694-p2sgaypq 348 15 . . . cord-313694-p2sgaypq 349 1 The the DT cord-313694-p2sgaypq 349 2 antibodies antibody NNS cord-313694-p2sgaypq 349 3 provide provide VBP cord-313694-p2sgaypq 349 4 unrivaled unrivaled JJ cord-313694-p2sgaypq 349 5 sensitivity sensitivity NN cord-313694-p2sgaypq 349 6 and and CC cord-313694-p2sgaypq 349 7 specificity specificity NN cord-313694-p2sgaypq 349 8 relative relative NN cord-313694-p2sgaypq 349 9 to to IN cord-313694-p2sgaypq 349 10 standard standard JJ cord-313694-p2sgaypq 349 11 methods method NNS cord-313694-p2sgaypq 349 12 for for IN cord-313694-p2sgaypq 349 13 detection detection NN cord-313694-p2sgaypq 349 14 of of IN cord-313694-p2sgaypq 349 15 unique unique JJ cord-313694-p2sgaypq 349 16 carbohydrate carbohydrate NN cord-313694-p2sgaypq 349 17 structures structure NNS cord-313694-p2sgaypq 349 18 . . . cord-313694-p2sgaypq 350 1 Caution caution NN cord-313694-p2sgaypq 350 2 must must MD cord-313694-p2sgaypq 350 3 be be VB cord-313694-p2sgaypq 350 4 applied apply VBN cord-313694-p2sgaypq 350 5 , , , cord-313694-p2sgaypq 350 6 however however RB cord-313694-p2sgaypq 350 7 , , , cord-313694-p2sgaypq 350 8 because because IN cord-313694-p2sgaypq 350 9 1 1 LS cord-313694-p2sgaypq 350 10 ) ) -RRB- cord-313694-p2sgaypq 350 11 it -PRON- PRP cord-313694-p2sgaypq 350 12 is be VBZ cord-313694-p2sgaypq 350 13 theoretically theoretically RB cord-313694-p2sgaypq 350 14 possible possible JJ cord-313694-p2sgaypq 350 15 that that IN cord-313694-p2sgaypq 350 16 unique unique JJ cord-313694-p2sgaypq 350 17 structures structure NNS cord-313694-p2sgaypq 350 18 at at IN cord-313694-p2sgaypq 350 19 the the DT cord-313694-p2sgaypq 350 20 monosaccharide monosaccharide NN cord-313694-p2sgaypq 350 21 level level NN cord-313694-p2sgaypq 350 22 may may MD cord-313694-p2sgaypq 350 23 present present VB cord-313694-p2sgaypq 350 24 structures structure NNS cord-313694-p2sgaypq 350 25 similar similar JJ cord-313694-p2sgaypq 350 26 enough enough RB cord-313694-p2sgaypq 350 27 at at IN cord-313694-p2sgaypq 350 28 the the DT cord-313694-p2sgaypq 350 29 atomic atomic JJ cord-313694-p2sgaypq 350 30 level level NN cord-313694-p2sgaypq 350 31 to to TO cord-313694-p2sgaypq 350 32 be be VB cord-313694-p2sgaypq 350 33 immunologically immunologically RB cord-313694-p2sgaypq 350 34 cross cross JJ cord-313694-p2sgaypq 350 35 - - JJ cord-313694-p2sgaypq 350 36 reactive reactive JJ cord-313694-p2sgaypq 350 37 and and CC cord-313694-p2sgaypq 350 38 2 2 LS cord-313694-p2sgaypq 350 39 ) ) -RRB- cord-313694-p2sgaypq 350 40 identical identical JJ cord-313694-p2sgaypq 350 41 or or CC cord-313694-p2sgaypq 350 42 similar similar JJ cord-313694-p2sgaypq 350 43 structures structure NNS cord-313694-p2sgaypq 350 44 may may MD cord-313694-p2sgaypq 350 45 be be VB cord-313694-p2sgaypq 350 46 immunologically immunologically RB cord-313694-p2sgaypq 350 47 distinguished distinguish VBN cord-313694-p2sgaypq 350 48 by by IN cord-313694-p2sgaypq 350 49 conformational conformational JJ cord-313694-p2sgaypq 350 50 restrictions restriction NNS cord-313694-p2sgaypq 350 51 imposed impose VBN cord-313694-p2sgaypq 350 52 by by IN cord-313694-p2sgaypq 350 53 the the DT cord-313694-p2sgaypq 350 54 surrounding surround VBG cord-313694-p2sgaypq 350 55 polypeptide polypeptide NN cord-313694-p2sgaypq 350 56 environment environment NN cord-313694-p2sgaypq 350 57 . . . cord-313694-p2sgaypq 351 1 Thus thus RB cord-313694-p2sgaypq 351 2 inference inference NN cord-313694-p2sgaypq 351 3 of of IN cord-313694-p2sgaypq 351 4 structure structure NN cord-313694-p2sgaypq 351 5 based base VBN cord-313694-p2sgaypq 351 6 on on IN cord-313694-p2sgaypq 351 7 antibody antibody NN cord-313694-p2sgaypq 351 8 data datum NNS cord-313694-p2sgaypq 351 9 must must MD cord-313694-p2sgaypq 351 10 be be VB cord-313694-p2sgaypq 351 11 confirmed confirm VBN cord-313694-p2sgaypq 351 12 directly directly RB cord-313694-p2sgaypq 351 13 by by IN cord-313694-p2sgaypq 351 14 structural structural JJ cord-313694-p2sgaypq 351 15 studies study NNS cord-313694-p2sgaypq 351 16 . . . cord-313694-p2sgaypq 352 1 In in IN cord-313694-p2sgaypq 352 2 any any DT cord-313694-p2sgaypq 352 3 case case NN cord-313694-p2sgaypq 352 4 , , , cord-313694-p2sgaypq 352 5 antibodies antibody NNS cord-313694-p2sgaypq 352 6 and and CC cord-313694-p2sgaypq 352 7 lectins lectin NNS cord-313694-p2sgaypq 352 8 may may MD cord-313694-p2sgaypq 352 9 model model VB cord-313694-p2sgaypq 352 10 potential potential JJ cord-313694-p2sgaypq 352 11 receptors receptor NNS cord-313694-p2sgaypq 352 12 in in IN cord-313694-p2sgaypq 352 13 cells cell NNS cord-313694-p2sgaypq 352 14 which which WDT cord-313694-p2sgaypq 352 15 might may MD cord-313694-p2sgaypq 352 16 specifically specifically RB cord-313694-p2sgaypq 352 17 recognize recognize VB cord-313694-p2sgaypq 352 18 carbohydrate carbohydrate NN cord-313694-p2sgaypq 352 19 - - HYPH cord-313694-p2sgaypq 352 20 associated associate VBN cord-313694-p2sgaypq 352 21 structures structure NNS cord-313694-p2sgaypq 352 22 . . . cord-313694-p2sgaypq 353 1 The the DT cord-313694-p2sgaypq 353 2 significance significance NN cord-313694-p2sgaypq 353 3 of of IN cord-313694-p2sgaypq 353 4 the the DT cord-313694-p2sgaypq 353 5 association association NN cord-313694-p2sgaypq 353 6 of of IN cord-313694-p2sgaypq 353 7 distinct distinct JJ cord-313694-p2sgaypq 353 8 carbohydrate carbohydrate NN cord-313694-p2sgaypq 353 9 structures structure NNS cord-313694-p2sgaypq 353 10 with with IN cord-313694-p2sgaypq 353 11 distinct distinct JJ cord-313694-p2sgaypq 353 12 embryonic embryonic JJ cord-313694-p2sgaypq 353 13 or or CC cord-313694-p2sgaypq 353 14 tumor tumor NN cord-313694-p2sgaypq 353 15 cell cell NN cord-313694-p2sgaypq 353 16 types type NNS cord-313694-p2sgaypq 353 17 is be VBZ cord-313694-p2sgaypq 353 18 absolutely absolutely RB cord-313694-p2sgaypq 353 19 unclear unclear JJ cord-313694-p2sgaypq 353 20 at at IN cord-313694-p2sgaypq 353 21 present present NN cord-313694-p2sgaypq 353 22 . . . cord-313694-p2sgaypq 354 1 Ultrastructural ultrastructural JJ cord-313694-p2sgaypq 354 2 localization localization NN cord-313694-p2sgaypq 354 3 has have VBZ cord-313694-p2sgaypq 354 4 placed place VBN cord-313694-p2sgaypq 354 5 some some DT cord-313694-p2sgaypq 354 6 epitopes epitope NNS cord-313694-p2sgaypq 354 7 intracellularly intracellularly RB cord-313694-p2sgaypq 354 8 in in IN cord-313694-p2sgaypq 354 9 specific specific JJ cord-313694-p2sgaypq 354 10 compartments compartment NNS cord-313694-p2sgaypq 354 11 and and CC cord-313694-p2sgaypq 354 12 others other NNS cord-313694-p2sgaypq 354 13 on on IN cord-313694-p2sgaypq 354 14 the the DT cord-313694-p2sgaypq 354 15 cell cell NN cord-313694-p2sgaypq 354 16 surface surface NN cord-313694-p2sgaypq 354 17 or or CC cord-313694-p2sgaypq 354 18 extracellularly extracellularly RB cord-313694-p2sgaypq 354 19 in in IN cord-313694-p2sgaypq 354 20 the the DT cord-313694-p2sgaypq 354 21 surrounding surround VBG cord-313694-p2sgaypq 354 22 matrix matrix NN cord-313694-p2sgaypq 354 23 . . . cord-313694-p2sgaypq 355 1 A a DT cord-313694-p2sgaypq 355 2 cell cell NN cord-313694-p2sgaypq 355 3 surface surface NN cord-313694-p2sgaypq 355 4 localization localization NN cord-313694-p2sgaypq 355 5 is be VBZ cord-313694-p2sgaypq 355 6 a a DT cord-313694-p2sgaypq 355 7 necessary necessary JJ cord-313694-p2sgaypq 355 8 condition condition NN cord-313694-p2sgaypq 355 9 for for IN cord-313694-p2sgaypq 355 10 a a DT cord-313694-p2sgaypq 355 11 direct direct JJ cord-313694-p2sgaypq 355 12 role role NN cord-313694-p2sgaypq 355 13 in in IN cord-313694-p2sgaypq 355 14 cell cell NN cord-313694-p2sgaypq 355 15 recognition recognition NN cord-313694-p2sgaypq 355 16 and and CC cord-313694-p2sgaypq 355 17 , , , cord-313694-p2sgaypq 355 18 on on IN cord-313694-p2sgaypq 355 19 the the DT cord-313694-p2sgaypq 355 20 strength strength NN cord-313694-p2sgaypq 355 21 of of IN cord-313694-p2sgaypq 355 22 suggestions suggestion NNS cord-313694-p2sgaypq 355 23 from from IN cord-313694-p2sgaypq 355 24 other other JJ cord-313694-p2sgaypq 355 25 systems system NNS cord-313694-p2sgaypq 355 26 , , , cord-313694-p2sgaypq 355 27 this this DT cord-313694-p2sgaypq 355 28 has have VBZ cord-313694-p2sgaypq 355 29 been be VBN cord-313694-p2sgaypq 355 30 promiscuously promiscuously RB cord-313694-p2sgaypq 355 31 interpreted interpret VBN cord-313694-p2sgaypq 355 32 to to TO cord-313694-p2sgaypq 355 33 imply imply VB cord-313694-p2sgaypq 355 34 a a DT cord-313694-p2sgaypq 355 35 role role NN cord-313694-p2sgaypq 355 36 in in IN cord-313694-p2sgaypq 355 37 cell cell NN cord-313694-p2sgaypq 355 38 recognition recognition NN cord-313694-p2sgaypq 355 39 . . . cord-313694-p2sgaypq 356 1 This this DT cord-313694-p2sgaypq 356 2 reflects reflect VBZ cord-313694-p2sgaypq 356 3 the the DT cord-313694-p2sgaypq 356 4 primitive primitive JJ cord-313694-p2sgaypq 356 5 status status NN cord-313694-p2sgaypq 356 6 of of IN cord-313694-p2sgaypq 356 7 our -PRON- PRP$ cord-313694-p2sgaypq 356 8 general general JJ cord-313694-p2sgaypq 356 9 understanding understanding NN cord-313694-p2sgaypq 356 10 of of IN cord-313694-p2sgaypq 356 11 the the DT cord-313694-p2sgaypq 356 12 significance significance NN cord-313694-p2sgaypq 356 13 of of IN cord-313694-p2sgaypq 356 14 protein protein NN cord-313694-p2sgaypq 356 15 glycosylation glycosylation NN cord-313694-p2sgaypq 356 16 . . . cord-313694-p2sgaypq 357 1 Thus thus RB cord-313694-p2sgaypq 357 2 the the DT cord-313694-p2sgaypq 357 3 potential potential JJ cord-313694-p2sgaypq 357 4 developmental developmental JJ cord-313694-p2sgaypq 357 5 roles role NNS cord-313694-p2sgaypq 357 6 of of IN cord-313694-p2sgaypq 357 7 protein protein NN cord-313694-p2sgaypq 357 8 - - HYPH cord-313694-p2sgaypq 357 9 linked link VBN cord-313694-p2sgaypq 357 10 carbohydrate carbohydrate NN cord-313694-p2sgaypq 357 11 in in IN cord-313694-p2sgaypq 357 12 morphogenesis morphogenesis NN cord-313694-p2sgaypq 357 13 , , , cord-313694-p2sgaypq 357 14 differentiation differentiation NN cord-313694-p2sgaypq 357 15 , , , cord-313694-p2sgaypq 357 16 adherence adherence NN cord-313694-p2sgaypq 357 17 and and CC cord-313694-p2sgaypq 357 18 proliferation proliferation NN cord-313694-p2sgaypq 357 19 will will MD cord-313694-p2sgaypq 357 20 likely likely RB cord-313694-p2sgaypq 357 21 be be VB cord-313694-p2sgaypq 357 22 a a DT cord-313694-p2sgaypq 357 23 primary primary JJ cord-313694-p2sgaypq 357 24 target target NN cord-313694-p2sgaypq 357 25 of of IN cord-313694-p2sgaypq 357 26 investigation investigation NN cord-313694-p2sgaypq 357 27 in in IN cord-313694-p2sgaypq 357 28 this this DT cord-313694-p2sgaypq 357 29 field field NN cord-313694-p2sgaypq 357 30 in in IN cord-313694-p2sgaypq 357 31 the the DT cord-313694-p2sgaypq 357 32 future future NN cord-313694-p2sgaypq 357 33 . . . cord-313694-p2sgaypq 358 1 Interest interest NN cord-313694-p2sgaypq 358 2 in in IN cord-313694-p2sgaypq 358 3 developmental developmental JJ cord-313694-p2sgaypq 358 4 involvement involvement NN cord-313694-p2sgaypq 358 5 of of IN cord-313694-p2sgaypq 358 6 carbohydrate carbohydrate NN cord-313694-p2sgaypq 358 7 is be VBZ cord-313694-p2sgaypq 358 8 based base VBN cord-313694-p2sgaypq 358 9 not not RB cord-313694-p2sgaypq 358 10 only only RB cord-313694-p2sgaypq 358 11 on on IN cord-313694-p2sgaypq 358 12 a a DT cord-313694-p2sgaypq 358 13 large large JJ cord-313694-p2sgaypq 358 14 bank bank NN cord-313694-p2sgaypq 358 15 of of IN cord-313694-p2sgaypq 358 16 indirect indirect JJ cord-313694-p2sgaypq 358 17 data datum NNS cord-313694-p2sgaypq 358 18 but but CC cord-313694-p2sgaypq 358 19 also also RB cord-313694-p2sgaypq 358 20 on on IN cord-313694-p2sgaypq 358 21 an an DT cord-313694-p2sgaypq 358 22 intrigue intrigue NN cord-313694-p2sgaypq 358 23 in in IN cord-313694-p2sgaypq 358 24 the the DT cord-313694-p2sgaypq 358 25 special special JJ cord-313694-p2sgaypq 358 26 kinds kind NNS cord-313694-p2sgaypq 358 27 of of IN cord-313694-p2sgaypq 358 28 epigenetic epigenetic JJ cord-313694-p2sgaypq 358 29 regulatory regulatory JJ cord-313694-p2sgaypq 358 30 mechanisms mechanism NNS cord-313694-p2sgaypq 358 31 with with IN cord-313694-p2sgaypq 358 32 which which WDT cord-313694-p2sgaypq 358 33 carbohydrate carbohydrate NN cord-313694-p2sgaypq 358 34 might may MD cord-313694-p2sgaypq 358 35 be be VB cord-313694-p2sgaypq 358 36 associated associate VBN cord-313694-p2sgaypq 358 37 . . . cord-313694-p2sgaypq 359 1 For for IN cord-313694-p2sgaypq 359 2 example example NN cord-313694-p2sgaypq 359 3 , , , cord-313694-p2sgaypq 359 4 glycosylation glycosylation NN cord-313694-p2sgaypq 359 5 offers offer VBZ cord-313694-p2sgaypq 359 6 the the DT cord-313694-p2sgaypq 359 7 cell cell NN cord-313694-p2sgaypq 359 8 a a DT cord-313694-p2sgaypq 359 9 mechanism mechanism NN cord-313694-p2sgaypq 359 10 to to TO cord-313694-p2sgaypq 359 11 regulate regulate VB cord-313694-p2sgaypq 359 12 the the DT cord-313694-p2sgaypq 359 13 structure structure NN cord-313694-p2sgaypq 359 14 of of IN cord-313694-p2sgaypq 359 15 multiple multiple JJ cord-313694-p2sgaypq 359 16 proteins protein NNS cord-313694-p2sgaypq 359 17 without without IN cord-313694-p2sgaypq 359 18 altering alter VBG cord-313694-p2sgaypq 359 19 gene gene NN cord-313694-p2sgaypq 359 20 expression expression NN cord-313694-p2sgaypq 359 21 . . . cord-313694-p2sgaypq 360 1 In in IN cord-313694-p2sgaypq 360 2 addition addition NN cord-313694-p2sgaypq 360 3 , , , cord-313694-p2sgaypq 360 4 monosaccharide monosaccharide NN cord-313694-p2sgaypq 360 5 residues residue NNS cord-313694-p2sgaypq 360 6 may may MD cord-313694-p2sgaypq 360 7 be be VB cord-313694-p2sgaypq 360 8 processed process VBN cord-313694-p2sgaypq 360 9 independently independently RB cord-313694-p2sgaypq 360 10 of of IN cord-313694-p2sgaypq 360 11 the the DT cord-313694-p2sgaypq 360 12 associated associated JJ cord-313694-p2sgaypq 360 13 polypeptide polypeptide NN cord-313694-p2sgaypq 360 14 ( ( -LRB- cord-313694-p2sgaypq 360 15 141 141 CD cord-313694-p2sgaypq 360 16 , , , cord-313694-p2sgaypq 360 17 142 142 CD cord-313694-p2sgaypq 360 18 ) ) -RRB- cord-313694-p2sgaypq 360 19 either either CC cord-313694-p2sgaypq 360 20 by by IN cord-313694-p2sgaypq 360 21 recycling recycle VBG cord-313694-p2sgaypq 360 22 through through IN cord-313694-p2sgaypq 360 23 the the DT cord-313694-p2sgaypq 360 24 Golgi Golgi NNP cord-313694-p2sgaypq 360 25 ( ( -LRB- cord-313694-p2sgaypq 360 26 112 112 CD cord-313694-p2sgaypq 360 27 ) ) -RRB- cord-313694-p2sgaypq 360 28 or or CC cord-313694-p2sgaypq 360 29 at at IN cord-313694-p2sgaypq 360 30 locations location NNS cord-313694-p2sgaypq 360 31 near near IN cord-313694-p2sgaypq 360 32 the the DT cord-313694-p2sgaypq 360 33 site site NN cord-313694-p2sgaypq 360 34 of of IN cord-313694-p2sgaypq 360 35 funtion funtion NN cord-313694-p2sgaypq 360 36 ( ( -LRB- cord-313694-p2sgaypq 360 37 130 130 CD cord-313694-p2sgaypq 360 38 , , , cord-313694-p2sgaypq 360 39 138 138 CD cord-313694-p2sgaypq 360 40 ) ) -RRB- cord-313694-p2sgaypq 360 41 , , , cord-313694-p2sgaypq 360 42 far far RB cord-313694-p2sgaypq 360 43 from from IN cord-313694-p2sgaypq 360 44 the the DT cord-313694-p2sgaypq 360 45 point point NN cord-313694-p2sgaypq 360 46 of of IN cord-313694-p2sgaypq 360 47 origin origin NN cord-313694-p2sgaypq 360 48 in in IN cord-313694-p2sgaypq 360 49 the the DT cord-313694-p2sgaypq 360 50 RER RER NNP cord-313694-p2sgaypq 360 51 and and CC cord-313694-p2sgaypq 360 52 Golgi Golgi NNP cord-313694-p2sgaypq 360 53 . . . cord-313694-p2sgaypq 361 1 It -PRON- PRP cord-313694-p2sgaypq 361 2 can can MD cord-313694-p2sgaypq 361 3 be be VB cord-313694-p2sgaypq 361 4 envisaged envisage VBN cord-313694-p2sgaypq 361 5 that that IN cord-313694-p2sgaypq 361 6 the the DT cord-313694-p2sgaypq 361 7 cell cell NN cord-313694-p2sgaypq 361 8 responded respond VBD cord-313694-p2sgaypq 361 9 to to IN cord-313694-p2sgaypq 361 10 the the DT cord-313694-p2sgaypq 361 11 evolutionary evolutionary JJ cord-313694-p2sgaypq 361 12 requirements requirement NNS cord-313694-p2sgaypq 361 13 for for IN cord-313694-p2sgaypq 361 14 cell cell NN cord-313694-p2sgaypq 361 15 differentiation differentiation NN cord-313694-p2sgaypq 361 16 by by IN cord-313694-p2sgaypq 361 17 using use VBG cord-313694-p2sgaypq 361 18 epigenetic epigenetic JJ cord-313694-p2sgaypq 361 19 pathways pathway NNS cord-313694-p2sgaypq 361 20 such such JJ cord-313694-p2sgaypq 361 21 as as IN cord-313694-p2sgaypq 361 22 glycosylation glycosylation NN cord-313694-p2sgaypq 361 23 and and CC cord-313694-p2sgaypq 361 24 other other JJ cord-313694-p2sgaypq 361 25 posttranslational posttranslational JJ cord-313694-p2sgaypq 361 26 modifications modification NNS cord-313694-p2sgaypq 361 27 ( ( -LRB- cord-313694-p2sgaypq 361 28 13 13 CD cord-313694-p2sgaypq 361 29 ) ) -RRB- cord-313694-p2sgaypq 361 30 . . . cord-313694-p2sgaypq 362 1 Consistent consistent JJ cord-313694-p2sgaypq 362 2 with with IN cord-313694-p2sgaypq 362 3 these these DT cord-313694-p2sgaypq 362 4 speculations speculation NNS cord-313694-p2sgaypq 362 5 , , , cord-313694-p2sgaypq 362 6 there there EX cord-313694-p2sgaypq 362 7 are be VBP cord-313694-p2sgaypq 362 8 , , , cord-313694-p2sgaypq 362 9 as as IN cord-313694-p2sgaypq 362 10 cited cite VBN cord-313694-p2sgaypq 362 11 above above RB cord-313694-p2sgaypq 362 12 , , , cord-313694-p2sgaypq 362 13 numerous numerous JJ cord-313694-p2sgaypq 362 14 examples example NNS cord-313694-p2sgaypq 362 15 of of IN cord-313694-p2sgaypq 362 16 glycosylation glycosylation NN cord-313694-p2sgaypq 362 17 steps step NNS cord-313694-p2sgaypq 362 18 modified modify VBN cord-313694-p2sgaypq 362 19 by by IN cord-313694-p2sgaypq 362 20 differentiation differentiation NN cord-313694-p2sgaypq 362 21 ( ( -LRB- cord-313694-p2sgaypq 362 22 56 56 CD cord-313694-p2sgaypq 362 23 ) ) -RRB- cord-313694-p2sgaypq 362 24 ( ( -LRB- cord-313694-p2sgaypq 362 25 57 57 CD cord-313694-p2sgaypq 362 26 ) ) -RRB- cord-313694-p2sgaypq 362 27 ( ( -LRB- cord-313694-p2sgaypq 362 28 58 58 CD cord-313694-p2sgaypq 362 29 ) ) -RRB- cord-313694-p2sgaypq 362 30 ( ( -LRB- cord-313694-p2sgaypq 362 31 59 59 CD cord-313694-p2sgaypq 362 32 ) ) -RRB- cord-313694-p2sgaypq 362 33 ( ( -LRB- cord-313694-p2sgaypq 362 34 60 60 CD cord-313694-p2sgaypq 362 35 ) ) -RRB- cord-313694-p2sgaypq 362 36 ( ( -LRB- cord-313694-p2sgaypq 362 37 61 61 CD cord-313694-p2sgaypq 362 38 ) ) -RRB- cord-313694-p2sgaypq 362 39 ( ( -LRB- cord-313694-p2sgaypq 362 40 62 62 CD cord-313694-p2sgaypq 362 41 ) ) -RRB- cord-313694-p2sgaypq 362 42 ( ( -LRB- cord-313694-p2sgaypq 362 43 63 63 CD cord-313694-p2sgaypq 362 44 ) ) -RRB- cord-313694-p2sgaypq 362 45 ( ( -LRB- cord-313694-p2sgaypq 362 46 64 64 CD cord-313694-p2sgaypq 362 47 ) ) -RRB- cord-313694-p2sgaypq 362 48 ( ( -LRB- cord-313694-p2sgaypq 362 49 65 65 CD cord-313694-p2sgaypq 362 50 ) ) -RRB- cord-313694-p2sgaypq 363 1 ( ( -LRB- cord-313694-p2sgaypq 363 2 66 66 CD cord-313694-p2sgaypq 363 3 ) ) -RRB- cord-313694-p2sgaypq 364 1 ( ( -LRB- cord-313694-p2sgaypq 364 2 67 67 CD cord-313694-p2sgaypq 364 3 ) ) -RRB- cord-313694-p2sgaypq 364 4 69 69 CD cord-313694-p2sgaypq 364 5 ) ) -RRB- cord-313694-p2sgaypq 364 6 , , , cord-313694-p2sgaypq 364 7 as as RB cord-313694-p2sgaypq 364 8 well well RB cord-313694-p2sgaypq 364 9 as as IN cord-313694-p2sgaypq 364 10 by by IN cord-313694-p2sgaypq 364 11 the the DT cord-313694-p2sgaypq 364 12 anchorage anchorage NNP cord-313694-p2sgaypq 364 13 state state NN cord-313694-p2sgaypq 364 14 of of IN cord-313694-p2sgaypq 364 15 the the DT cord-313694-p2sgaypq 364 16 cell cell NN cord-313694-p2sgaypq 364 17 and and CC cord-313694-p2sgaypq 364 18 the the DT cord-313694-p2sgaypq 364 19 pH ph NN cord-313694-p2sgaypq 364 20 and and CC cord-313694-p2sgaypq 364 21 composition composition NN cord-313694-p2sgaypq 364 22 of of IN cord-313694-p2sgaypq 364 23 the the DT cord-313694-p2sgaypq 364 24 surrounding surround VBG cord-313694-p2sgaypq 364 25 medium medium NN cord-313694-p2sgaypq 364 26 ( ( -LRB- cord-313694-p2sgaypq 364 27 39 39 CD cord-313694-p2sgaypq 364 28 , , , cord-313694-p2sgaypq 364 29 36 36 CD cord-313694-p2sgaypq 364 30 ) ) -RRB- cord-313694-p2sgaypq 364 31 . . . cord-313694-p2sgaypq 365 1 An an DT cord-313694-p2sgaypq 365 2 example example NN cord-313694-p2sgaypq 365 3 of of IN cord-313694-p2sgaypq 365 4 what what WP cord-313694-p2sgaypq 365 5 the the DT cord-313694-p2sgaypq 365 6 future future NN cord-313694-p2sgaypq 365 7 may may MD cord-313694-p2sgaypq 365 8 bear bear VB cord-313694-p2sgaypq 365 9 is be VBZ cord-313694-p2sgaypq 365 10 exemplified exemplify VBN cord-313694-p2sgaypq 365 11 by by IN cord-313694-p2sgaypq 365 12 a a DT cord-313694-p2sgaypq 365 13 group group NN cord-313694-p2sgaypq 365 14 of of IN cord-313694-p2sgaypq 365 15 developmental developmental JJ cord-313694-p2sgaypq 365 16 arrest arrest NN cord-313694-p2sgaypq 365 17 mutants mutant NNS cord-313694-p2sgaypq 365 18 recently recently RB cord-313694-p2sgaypq 365 19 characterized characterize VBN cord-313694-p2sgaypq 365 20 in in IN cord-313694-p2sgaypq 365 21 D. D. NNP cord-313694-p2sgaypq 365 22 discoideum discoideum NNP cord-313694-p2sgaypq 365 23 ( ( -LRB- cord-313694-p2sgaypq 365 24 147 147 CD cord-313694-p2sgaypq 365 25 ) ) -RRB- cord-313694-p2sgaypq 365 26 . . . cord-313694-p2sgaypq 366 1 Isolated isolate VBN cord-313694-p2sgaypq 366 2 on on IN cord-313694-p2sgaypq 366 3 the the DT cord-313694-p2sgaypq 366 4 basis basis NN cord-313694-p2sgaypq 366 5 of of IN cord-313694-p2sgaypq 366 6 failure failure NN cord-313694-p2sgaypq 366 7 to to TO cord-313694-p2sgaypq 366 8 accumulate accumulate VB cord-313694-p2sgaypq 366 9 an an DT cord-313694-p2sgaypq 366 10 early early JJ cord-313694-p2sgaypq 366 11 regulated regulate VBN cord-313694-p2sgaypq 366 12 enzyme enzyme NN cord-313694-p2sgaypq 366 13 , , , cord-313694-p2sgaypq 366 14 many many JJ cord-313694-p2sgaypq 366 15 of of IN cord-313694-p2sgaypq 366 16 these these DT cord-313694-p2sgaypq 366 17 mutants mutant NNS cord-313694-p2sgaypq 366 18 appear appear VBP cord-313694-p2sgaypq 366 19 to to TO cord-313694-p2sgaypq 366 20 be be VB cord-313694-p2sgaypq 366 21 altered alter VBN cord-313694-p2sgaypq 366 22 in in IN cord-313694-p2sgaypq 366 23 posttranslational posttranslational JJ cord-313694-p2sgaypq 366 24 modifications modification NNS cord-313694-p2sgaypq 366 25 , , , cord-313694-p2sgaypq 366 26 including include VBG cord-313694-p2sgaypq 366 27 glycosylation glycosylation NN cord-313694-p2sgaypq 366 28 . . . cord-313694-p2sgaypq 367 1 Thus thus RB cord-313694-p2sgaypq 367 2 many many JJ cord-313694-p2sgaypq 367 3 potentially potentially RB cord-313694-p2sgaypq 367 4 necessary necessary JJ cord-313694-p2sgaypq 367 5 roles role NNS cord-313694-p2sgaypq 367 6 played play VBN cord-313694-p2sgaypq 367 7 by by IN cord-313694-p2sgaypq 367 8 glycosylation glycosylation NN cord-313694-p2sgaypq 367 9 in in IN cord-313694-p2sgaypq 367 10 development development NN cord-313694-p2sgaypq 367 11 remain remain VBP cord-313694-p2sgaypq 367 12 unexplored unexplored JJ cord-313694-p2sgaypq 367 13 . . . cord-313694-p2sgaypq 368 1 15 15 CD cord-313694-p2sgaypq 368 2 been be VBN cord-313694-p2sgaypq 368 3 shown show VBN cord-313694-p2sgaypq 368 4 that that IN cord-313694-p2sgaypq 368 5 carbohydrate carbohydrate NN cord-313694-p2sgaypq 368 6 interaction interaction NN cord-313694-p2sgaypq 368 7 is be VBZ cord-313694-p2sgaypq 368 8 multivalent multivalent JJ cord-313694-p2sgaypq 368 9 , , , cord-313694-p2sgaypq 368 10 composed compose VBN cord-313694-p2sgaypq 368 11 of of IN cord-313694-p2sgaypq 368 12 multiple multiple JJ cord-313694-p2sgaypq 368 13 weak weak JJ cord-313694-p2sgaypq 368 14 associations association NNS cord-313694-p2sgaypq 368 15 which which WDT cord-313694-p2sgaypq 368 16 only only RB cord-313694-p2sgaypq 368 17 in in IN cord-313694-p2sgaypq 368 18 aggregate aggregate NN cord-313694-p2sgaypq 368 19 are be VBP cord-313694-p2sgaypq 368 20 strong strong JJ cord-313694-p2sgaypq 368 21 ( ( -LRB- cord-313694-p2sgaypq 368 22 155 155 CD cord-313694-p2sgaypq 368 23 , , , cord-313694-p2sgaypq 368 24 123 123 CD cord-313694-p2sgaypq 368 25 , , , cord-313694-p2sgaypq 368 26 172 172 CD cord-313694-p2sgaypq 368 27 ) ) -RRB- cord-313694-p2sgaypq 368 28 . . . cord-313694-p2sgaypq 369 1 It -PRON- PRP cord-313694-p2sgaypq 369 2 would would MD cord-313694-p2sgaypq 369 3 appear appear VB cord-313694-p2sgaypq 369 4 that that IN cord-313694-p2sgaypq 369 5 most most JJS cord-313694-p2sgaypq 369 6 protein protein NN cord-313694-p2sgaypq 369 7 - - HYPH cord-313694-p2sgaypq 369 8 linked link VBN cord-313694-p2sgaypq 369 9 carbohydrate carbohydrate NN cord-313694-p2sgaypq 369 10 is be VBZ cord-313694-p2sgaypq 369 11 not not RB cord-313694-p2sgaypq 369 12 solely solely RB cord-313694-p2sgaypq 369 13 responsible responsible JJ cord-313694-p2sgaypq 369 14 for for IN cord-313694-p2sgaypq 369 15 the the DT cord-313694-p2sgaypq 369 16 essential essential JJ cord-313694-p2sgaypq 369 17 housekeeping housekeeping NN cord-313694-p2sgaypq 369 18 functions function NNS cord-313694-p2sgaypq 369 19 of of IN cord-313694-p2sgaypq 369 20 cells cell NNS cord-313694-p2sgaypq 369 21 required require VBN cord-313694-p2sgaypq 369 22 for for IN cord-313694-p2sgaypq 369 23 life life NN cord-313694-p2sgaypq 369 24 in in IN cord-313694-p2sgaypq 369 25 the the DT cord-313694-p2sgaypq 369 26 tissue tissue NN cord-313694-p2sgaypq 369 27 culture culture NN cord-313694-p2sgaypq 369 28 environment environment NN cord-313694-p2sgaypq 369 29 . . . cord-313694-p2sgaypq 370 1 Perhaps perhaps RB cord-313694-p2sgaypq 370 2 this this DT cord-313694-p2sgaypq 370 3 is be VBZ cord-313694-p2sgaypq 370 4 because because IN cord-313694-p2sgaypq 370 5 specification specification NN cord-313694-p2sgaypq 370 6 of of IN cord-313694-p2sgaypq 370 7 its -PRON- PRP$ cord-313694-p2sgaypq 370 8 structure structure NN cord-313694-p2sgaypq 370 9 , , , cord-313694-p2sgaypq 370 10 which which WDT cord-313694-p2sgaypq 370 11 is be VBZ cord-313694-p2sgaypq 370 12 nontemplate nontemplate NN cord-313694-p2sgaypq 370 13 - - HYPH cord-313694-p2sgaypq 370 14 directed direct VBN cord-313694-p2sgaypq 370 15 , , , cord-313694-p2sgaypq 370 16 is be VBZ cord-313694-p2sgaypq 370 17 not not RB cord-313694-p2sgaypq 370 18 precise precise JJ cord-313694-p2sgaypq 370 19 enough enough RB cord-313694-p2sgaypq 370 20 . . . cord-313694-p2sgaypq 371 1 Glycosylation glycosylation NN cord-313694-p2sgaypq 371 2 presumably presumably RB cord-313694-p2sgaypq 371 3 has have VBZ cord-313694-p2sgaypq 371 4 instead instead RB cord-313694-p2sgaypq 371 5 afforded afford VBN cord-313694-p2sgaypq 371 6 the the DT cord-313694-p2sgaypq 371 7 cell cell NN cord-313694-p2sgaypq 371 8 , , , cord-313694-p2sgaypq 371 9 during during IN cord-313694-p2sgaypq 371 10 the the DT cord-313694-p2sgaypq 371 11 evolution evolution NN cord-313694-p2sgaypq 371 12 of of IN cord-313694-p2sgaypq 371 13 developmental developmental JJ cord-313694-p2sgaypq 371 14 mechanisms mechanism NNS cord-313694-p2sgaypq 371 15 , , , cord-313694-p2sgaypq 371 16 an an DT cord-313694-p2sgaypq 371 17 economy economy NN cord-313694-p2sgaypq 371 18 in in IN cord-313694-p2sgaypq 371 19 allowing allow VBG cord-313694-p2sgaypq 371 20 the the DT cord-313694-p2sgaypq 371 21 structural structural JJ cord-313694-p2sgaypq 371 22 modification modification NN cord-313694-p2sgaypq 371 23 of of IN cord-313694-p2sgaypq 371 24 many many JJ cord-313694-p2sgaypq 371 25 preexisting preexisting JJ cord-313694-p2sgaypq 371 26 proteins protein NNS cord-313694-p2sgaypq 371 27 using use VBG cord-313694-p2sgaypq 371 28 the the DT cord-313694-p2sgaypq 371 29 same same JJ cord-313694-p2sgaypq 371 30 enzymatic enzymatic JJ cord-313694-p2sgaypq 371 31 mechanism mechanism NN cord-313694-p2sgaypq 371 32 . . . cord-313694-p2sgaypq 372 1 It -PRON- PRP cord-313694-p2sgaypq 372 2 provides provide VBZ cord-313694-p2sgaypq 372 3 the the DT cord-313694-p2sgaypq 372 4 cell cell NN cord-313694-p2sgaypq 372 5 with with IN cord-313694-p2sgaypq 372 6 another another DT cord-313694-p2sgaypq 372 7 control control NN cord-313694-p2sgaypq 372 8 point point NN cord-313694-p2sgaypq 372 9 over over IN cord-313694-p2sgaypq 372 10 structure structure NN cord-313694-p2sgaypq 372 11 which which WDT cord-313694-p2sgaypq 372 12 can can MD cord-313694-p2sgaypq 372 13 be be VB cord-313694-p2sgaypq 372 14 exerted exert VBN cord-313694-p2sgaypq 372 15 on on IN cord-313694-p2sgaypq 372 16 many many JJ cord-313694-p2sgaypq 372 17 proteins protein NNS cord-313694-p2sgaypq 372 18 at at IN cord-313694-p2sgaypq 372 19 the the DT cord-313694-p2sgaypq 372 20 site site NN cord-313694-p2sgaypq 372 21 of of IN cord-313694-p2sgaypq 372 22 function function NN cord-313694-p2sgaypq 372 23 ( ( -LRB- cord-313694-p2sgaypq 372 24 away away RB cord-313694-p2sgaypq 372 25 from from IN cord-313694-p2sgaypq 372 26 the the DT cord-313694-p2sgaypq 372 27 site site NN cord-313694-p2sgaypq 372 28 of of IN cord-313694-p2sgaypq 372 29 synthesis synthesis NN cord-313694-p2sgaypq 372 30 ) ) -RRB- cord-313694-p2sgaypq 372 31 without without IN cord-313694-p2sgaypq 372 32 necessitating necessitate VBG cord-313694-p2sgaypq 372 33 a a DT cord-313694-p2sgaypq 372 34 change change NN cord-313694-p2sgaypq 372 35 in in IN cord-313694-p2sgaypq 372 36 gene gene NN cord-313694-p2sgaypq 372 37 expression expression NN cord-313694-p2sgaypq 372 38 . . . cord-313694-p2sgaypq 373 1 Change change VB cord-313694-p2sgaypq 373 2 in in IN cord-313694-p2sgaypq 373 3 structure structure NN cord-313694-p2sgaypq 373 4 by by IN cord-313694-p2sgaypq 373 5 glycosylation glycosylation NN cord-313694-p2sgaypq 373 6 may may MD cord-313694-p2sgaypq 373 7 be be VB cord-313694-p2sgaypq 373 8 very very RB cord-313694-p2sgaypq 373 9 suitable suitable JJ cord-313694-p2sgaypq 373 10 for for IN cord-313694-p2sgaypq 373 11 the the DT cord-313694-p2sgaypq 373 12 regulation regulation NN cord-313694-p2sgaypq 373 13 of of IN cord-313694-p2sgaypq 373 14 the the DT cord-313694-p2sgaypq 373 15 ' ' `` cord-313694-p2sgaypq 373 16 luxury luxury NN cord-313694-p2sgaypq 373 17 ' ' '' cord-313694-p2sgaypq 373 18 functions function NNS cord-313694-p2sgaypq 373 19 of of IN cord-313694-p2sgaypq 373 20 cell cell NN cord-313694-p2sgaypq 373 21 differentiation differentiation NN cord-313694-p2sgaypq 373 22 and and CC cord-313694-p2sgaypq 373 23 morphogenesis morphogenesis NN cord-313694-p2sgaypq 373 24 . . . cord-313694-p2sgaypq 374 1 An an DT cord-313694-p2sgaypq 374 2 economy economy NN cord-313694-p2sgaypq 374 3 of of IN cord-313694-p2sgaypq 374 4 shared share VBN cord-313694-p2sgaypq 374 5 non non JJ cord-313694-p2sgaypq 374 6 - - JJ cord-313694-p2sgaypq 374 7 specifc specifc JJ cord-313694-p2sgaypq 374 8 and and CC cord-313694-p2sgaypq 374 9 specific specific JJ cord-313694-p2sgaypq 374 10 functions function NNS cord-313694-p2sgaypq 374 11 of of IN cord-313694-p2sgaypq 374 12 carbohydrate carbohydrate NN cord-313694-p2sgaypq 374 13 would would MD cord-313694-p2sgaypq 374 14 thus thus RB cord-313694-p2sgaypq 374 15 offer offer VB cord-313694-p2sgaypq 374 16 an an DT cord-313694-p2sgaypq 374 17 unifying unifying JJ cord-313694-p2sgaypq 374 18 explanation explanation NN cord-313694-p2sgaypq 374 19 for for IN cord-313694-p2sgaypq 374 20 the the DT cord-313694-p2sgaypq 374 21 often often RB cord-313694-p2sgaypq 374 22 contradictory contradictory JJ cord-313694-p2sgaypq 374 23 conclusions conclusion NNS cord-313694-p2sgaypq 374 24 yielded yield VBD cord-313694-p2sgaypq 374 25 from from IN cord-313694-p2sgaypq 374 26 the the DT cord-313694-p2sgaypq 374 27 varied varied JJ cord-313694-p2sgaypq 374 28 experimental experimental JJ cord-313694-p2sgaypq 374 29 approaches approach NNS cord-313694-p2sgaypq 374 30 summarized summarize VBN cord-313694-p2sgaypq 374 31 in in IN cord-313694-p2sgaypq 374 32 this this DT cord-313694-p2sgaypq 374 33 article article NN cord-313694-p2sgaypq 374 34 . . . cord-313694-p2sgaypq 375 1 The the DT cord-313694-p2sgaypq 375 2 nearly nearly RB cord-313694-p2sgaypq 375 3 ubiquitous ubiquitous JJ cord-313694-p2sgaypq 375 4 glycosylation glycosylation NN cord-313694-p2sgaypq 375 5 of of IN cord-313694-p2sgaypq 375 6 extracellular extracellular JJ cord-313694-p2sgaypq 375 7 and and CC cord-313694-p2sgaypq 375 8 cell cell NN cord-313694-p2sgaypq 375 9 surface surface NN cord-313694-p2sgaypq 375 10 proteins protein NNS cord-313694-p2sgaypq 375 11 and and CC cord-313694-p2sgaypq 375 12 proteins protein NNS cord-313694-p2sgaypq 375 13 from from IN cord-313694-p2sgaypq 375 14 certain certain JJ cord-313694-p2sgaypq 375 15 organelles organelle NNS cord-313694-p2sgaypq 375 16 may may MD cord-313694-p2sgaypq 375 17 reflect reflect VB cord-313694-p2sgaypq 375 18 a a DT cord-313694-p2sgaypq 375 19 primitive primitive JJ cord-313694-p2sgaypq 375 20 , , , cord-313694-p2sgaypq 375 21 nonspecific nonspecific JJ cord-313694-p2sgaypq 375 22 function function NN cord-313694-p2sgaypq 375 23 supporting support VBG cord-313694-p2sgaypq 375 24 protein protein NN cord-313694-p2sgaypq 375 25 structure structure NN cord-313694-p2sgaypq 375 26 and and CC cord-313694-p2sgaypq 375 27 protection protection NN cord-313694-p2sgaypq 375 28 . . . cord-313694-p2sgaypq 376 1 This this DT cord-313694-p2sgaypq 376 2 carbohydrate carbohydrate NN cord-313694-p2sgaypq 376 3 carries carry VBZ cord-313694-p2sgaypq 376 4 out out RP cord-313694-p2sgaypq 376 5 a a DT cord-313694-p2sgaypq 376 6 shared share VBN cord-313694-p2sgaypq 376 7 function function NN cord-313694-p2sgaypq 376 8 , , , cord-313694-p2sgaypq 376 9 however however RB cord-313694-p2sgaypq 376 10 , , , cord-313694-p2sgaypq 376 11 when when WRB cord-313694-p2sgaypq 376 12 it -PRON- PRP cord-313694-p2sgaypq 376 13 becomes become VBZ cord-313694-p2sgaypq 376 14 modified modify VBN cord-313694-p2sgaypq 376 15 in in IN cord-313694-p2sgaypq 376 16 subtle subtle JJ cord-313694-p2sgaypq 376 17 ways way NNS cord-313694-p2sgaypq 376 18 without without IN cord-313694-p2sgaypq 376 19 affecting affect VBG cord-313694-p2sgaypq 376 20 non non JJ cord-313694-p2sgaypq 376 21 - - JJ cord-313694-p2sgaypq 376 22 specific specific JJ cord-313694-p2sgaypq 376 23 functions function NNS cord-313694-p2sgaypq 376 24 , , , cord-313694-p2sgaypq 376 25 to to TO cord-313694-p2sgaypq 376 26 allow allow VB cord-313694-p2sgaypq 376 27 discrimination discrimination NN cord-313694-p2sgaypq 376 28 by by IN cord-313694-p2sgaypq 376 29 receptors receptor NNS cord-313694-p2sgaypq 376 30 . . . cord-313694-p2sgaypq 377 1 Recognition recognition NN cord-313694-p2sgaypq 377 2 by by IN cord-313694-p2sgaypq 377 3 discriminate discriminate NN cord-313694-p2sgaypq 377 4 receptors receptor NNS cord-313694-p2sgaypq 377 5 allows allow VBZ cord-313694-p2sgaypq 377 6 the the DT cord-313694-p2sgaypq 377 7 carbohydrate carbohydrate NN cord-313694-p2sgaypq 377 8 to to IN cord-313694-p2sgaypq 377 9 subserve subserve VB cord-313694-p2sgaypq 377 10 specific specific JJ cord-313694-p2sgaypq 377 11 functions function NNS cord-313694-p2sgaypq 377 12 . . . cord-313694-p2sgaypq 378 1 Carbohydrate carbohydrate NN cord-313694-p2sgaypq 378 2 would would MD cord-313694-p2sgaypq 378 3 appear appear VB cord-313694-p2sgaypq 378 4 to to TO cord-313694-p2sgaypq 378 5 be be VB cord-313694-p2sgaypq 378 6 used use VBN cord-313694-p2sgaypq 378 7 by by IN cord-313694-p2sgaypq 378 8 cells cell NNS cord-313694-p2sgaypq 378 9 to to TO cord-313694-p2sgaypq 378 10 carry carry VB cord-313694-p2sgaypq 378 11 out out RP cord-313694-p2sgaypq 378 12 secondary secondary JJ cord-313694-p2sgaypq 378 13 functions function NNS cord-313694-p2sgaypq 378 14 ( ( -LRB- cord-313694-p2sgaypq 378 15 both both DT cord-313694-p2sgaypq 378 16 specific specific JJ cord-313694-p2sgaypq 378 17 and and CC cord-313694-p2sgaypq 378 18 non non JJ cord-313694-p2sgaypq 378 19 - - JJ cord-313694-p2sgaypq 378 20 specific specific JJ cord-313694-p2sgaypq 378 21 ) ) -RRB- cord-313694-p2sgaypq 378 22 for for IN cord-313694-p2sgaypq 378 23 proteins protein NNS cord-313694-p2sgaypq 378 24 . . . cord-313694-p2sgaypq 379 1 These these DT cord-313694-p2sgaypq 379 2 include include VBP cord-313694-p2sgaypq 379 3 specialized specialize VBN cord-313694-p2sgaypq 379 4 instances instance NNS cord-313694-p2sgaypq 379 5 of of IN cord-313694-p2sgaypq 379 6 compartmentalization compartmentalization NN cord-313694-p2sgaypq 379 7 , , , cord-313694-p2sgaypq 379 8 rate rate NN cord-313694-p2sgaypq 379 9 of of IN cord-313694-p2sgaypq 379 10 transport transport NN cord-313694-p2sgaypq 379 11 through through IN cord-313694-p2sgaypq 379 12 the the DT cord-313694-p2sgaypq 379 13 cell cell NN cord-313694-p2sgaypq 379 14 , , , cord-313694-p2sgaypq 379 15 intermolecular intermolecular NNP cord-313694-p2sgaypq 379 16 association association NNP cord-313694-p2sgaypq 379 17 , , , cord-313694-p2sgaypq 379 18 conformation conformation NN cord-313694-p2sgaypq 379 19 control control NN cord-313694-p2sgaypq 379 20 and and CC cord-313694-p2sgaypq 379 21 general general JJ cord-313694-p2sgaypq 379 22 protection protection NN cord-313694-p2sgaypq 379 23 . . . cord-313694-p2sgaypq 380 1 Interaction interaction NN cord-313694-p2sgaypq 380 2 of of IN cord-313694-p2sgaypq 380 3 the the DT cord-313694-p2sgaypq 380 4 cell cell NN cord-313694-p2sgaypq 380 5 with with IN cord-313694-p2sgaypq 380 6 the the DT cord-313694-p2sgaypq 380 7 environment environment NN cord-313694-p2sgaypq 380 8 , , , cord-313694-p2sgaypq 380 9 which which WDT cord-313694-p2sgaypq 380 10 is be VBZ cord-313694-p2sgaypq 380 11 in in IN cord-313694-p2sgaypq 380 12 a a DT cord-313694-p2sgaypq 380 13 sense sense NN cord-313694-p2sgaypq 380 14 secondary secondary JJ cord-313694-p2sgaypq 380 15 to to IN cord-313694-p2sgaypq 380 16 the the DT cord-313694-p2sgaypq 380 17 life life NN cord-313694-p2sgaypq 380 18 of of IN cord-313694-p2sgaypq 380 19 the the DT cord-313694-p2sgaypq 380 20 cell cell NN cord-313694-p2sgaypq 380 21 , , , cord-313694-p2sgaypq 380 22 would would MD cord-313694-p2sgaypq 380 23 also also RB cord-313694-p2sgaypq 380 24 appear appear VB cord-313694-p2sgaypq 380 25 to to TO cord-313694-p2sgaypq 380 26 involve involve VB cord-313694-p2sgaypq 380 27 protein protein NN cord-313694-p2sgaypq 380 28 - - HYPH cord-313694-p2sgaypq 380 29 linked link VBN cord-313694-p2sgaypq 380 30 carbohydrate carbohydrate NN cord-313694-p2sgaypq 380 31 . . . cord-313694-p2sgaypq 381 1 This this DT cord-313694-p2sgaypq 381 2 might may MD cord-313694-p2sgaypq 381 3 include include VB cord-313694-p2sgaypq 381 4 compartmentalization compartmentalization NN cord-313694-p2sgaypq 381 5 or or CC cord-313694-p2sgaypq 381 6 sorting sorting NN cord-313694-p2sgaypq 381 7 of of IN cord-313694-p2sgaypq 381 8 cells cell NNS cord-313694-p2sgaypq 381 9 into into IN cord-313694-p2sgaypq 381 10 tissues tissue NNS cord-313694-p2sgaypq 381 11 . . . cord-313694-p2sgaypq 382 1 In in IN cord-313694-p2sgaypq 382 2 several several JJ cord-313694-p2sgaypq 382 3 instances instance NNS cord-313694-p2sgaypq 382 4 it -PRON- PRP cord-313694-p2sgaypq 382 5 has have VBZ cord-313694-p2sgaypq 382 6 Structure structure NN cord-313694-p2sgaypq 382 7 , , , cord-313694-p2sgaypq 382 8 biosynthesis biosynthesis NN cord-313694-p2sgaypq 382 9 and and CC cord-313694-p2sgaypq 382 10 functions function NNS cord-313694-p2sgaypq 382 11 of of IN cord-313694-p2sgaypq 382 12 glycoprotein glycoprotein NN cord-313694-p2sgaypq 382 13 glycans glycan NNS cord-313694-p2sgaypq 382 14 Carbohydrate carbohydrate JJ cord-313694-p2sgaypq 382 15 moieties moiety NNS cord-313694-p2sgaypq 382 16 of of IN cord-313694-p2sgaypq 382 17 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 382 18 Complex complex JJ cord-313694-p2sgaypq 382 19 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 382 20 of of IN cord-313694-p2sgaypq 382 21 the the DT cord-313694-p2sgaypq 382 22 extracellnlar extracellnlar JJ cord-313694-p2sgaypq 382 23 matrix matrix NN cord-313694-p2sgaypq 382 24 . . . cord-313694-p2sgaypq 383 1 Structures structure NNS cord-313694-p2sgaypq 383 2 , , , cord-313694-p2sgaypq 383 3 interactions interaction NNS cord-313694-p2sgaypq 383 4 and and CC cord-313694-p2sgaypq 383 5 biological biological JJ cord-313694-p2sgaypq 383 6 roles role NNS cord-313694-p2sgaypq 383 7 Glycoprotein Glycoprotein NNP cord-313694-p2sgaypq 383 8 biosynthesis biosynthesis NN cord-313694-p2sgaypq 383 9 in in IN cord-313694-p2sgaypq 383 10 yeast yeast NN cord-313694-p2sgaypq 383 11 Control Control NNP cord-313694-p2sgaypq 383 12 of of IN cord-313694-p2sgaypq 383 13 asparagine asparagine NN cord-313694-p2sgaypq 383 14 - - HYPH cord-313694-p2sgaypq 383 15 linked link VBN cord-313694-p2sgaypq 383 16 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 383 17 chain chain NN cord-313694-p2sgaypq 383 18 processing processing NN cord-313694-p2sgaypq 383 19 : : : cord-313694-p2sgaypq 383 20 studies study NNS cord-313694-p2sgaypq 383 21 on on IN cord-313694-p2sgaypq 383 22 bovine bovine JJ cord-313694-p2sgaypq 383 23 pancreatic pancreatic NN cord-313694-p2sgaypq 383 24 ribonuclease ribonuclease NN cord-313694-p2sgaypq 383 25 B B NNP cord-313694-p2sgaypq 383 26 Correlation correlation NN cord-313694-p2sgaypq 383 27 of of IN cord-313694-p2sgaypq 383 28 glycosylation glycosylation NN cord-313694-p2sgaypq 383 29 forms form NNS cord-313694-p2sgaypq 383 30 with with IN cord-313694-p2sgaypq 383 31 position position NN cord-313694-p2sgaypq 383 32 in in IN cord-313694-p2sgaypq 383 33 amino amino NN cord-313694-p2sgaypq 383 34 acid acid NN cord-313694-p2sgaypq 383 35 sequence sequence NN cord-313694-p2sgaypq 384 1 Lysosomal Lysosomal NNP cord-313694-p2sgaypq 384 2 enzyme enzyme NN cord-313694-p2sgaypq 384 3 phosphorylation phosphorylation NN cord-313694-p2sgaypq 384 4 Occurrence occurrence NN cord-313694-p2sgaypq 384 5 of of IN cord-313694-p2sgaypq 384 6 N n CD cord-313694-p2sgaypq 384 7 - - HYPH cord-313694-p2sgaypq 384 8 acetylglucosamine acetylglucosamine NN cord-313694-p2sgaypq 384 9 6-phosphate 6-phosphate NN cord-313694-p2sgaypq 384 10 in in IN cord-313694-p2sgaypq 384 11 complex complex JJ cord-313694-p2sgaypq 384 12 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 384 13 -0-methylation -0-methylation NN cord-313694-p2sgaypq 384 14 of of IN cord-313694-p2sgaypq 384 15 mannose mannose NN cord-313694-p2sgaypq 384 16 residues residue NNS cord-313694-p2sgaypq 384 17 Transient transient JJ cord-313694-p2sgaypq 384 18 metbylation metbylation NN cord-313694-p2sgaypq 384 19 of of IN cord-313694-p2sgaypq 384 20 dolichyl dolichyl NNP cord-313694-p2sgaypq 384 21 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 384 22 is be VBZ cord-313694-p2sgaypq 384 23 an an DT cord-313694-p2sgaypq 384 24 obligatory obligatory JJ cord-313694-p2sgaypq 384 25 step step NN cord-313694-p2sgaypq 384 26 in in IN cord-313694-p2sgaypq 384 27 halobacterial halobacterial JJ cord-313694-p2sgaypq 384 28 sulfated sulfated JJ cord-313694-p2sgaypq 384 29 glycoprotein glycoprotein NN cord-313694-p2sgaypq 384 30 biosynthesis biosynthesis NN cord-313694-p2sgaypq 384 31 Glycoproteins Glycoproteins NNP cord-313694-p2sgaypq 384 32 as as IN cord-313694-p2sgaypq 384 33 ceil ceil NN cord-313694-p2sgaypq 384 34 - - HYPH cord-313694-p2sgaypq 384 35 surface surface NN cord-313694-p2sgaypq 384 36 components component NNS cord-313694-p2sgaypq 384 37 Either either CC cord-313694-p2sgaypq 384 38 high high JJ cord-313694-p2sgaypq 384 39 - - HYPH cord-313694-p2sgaypq 384 40 mannose mannose NN cord-313694-p2sgaypq 384 41 - - HYPH cord-313694-p2sgaypq 384 42 type type NN cord-313694-p2sgaypq 384 43 or or CC cord-313694-p2sgaypq 384 44 hybrid hybrid JJ cord-313694-p2sgaypq 384 45 type type NN cord-313694-p2sgaypq 384 46 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 384 47 is be VBZ cord-313694-p2sgaypq 384 48 linked link VBN cord-313694-p2sgaypq 384 49 to to IN cord-313694-p2sgaypq 384 50 the the DT cord-313694-p2sgaypq 384 51 same same JJ cord-313694-p2sgaypq 384 52 asparagine asparagine NN cord-313694-p2sgaypq 384 53 residue residue NN cord-313694-p2sgaypq 384 54 in in IN cord-313694-p2sgaypq 384 55 ovalbumin ovalbumin JJ cord-313694-p2sgaypq 384 56 Posttranslational Posttranslational NNP cord-313694-p2sgaypq 384 57 covalent covalent JJ cord-313694-p2sgaypq 384 58 modification modification NN cord-313694-p2sgaypq 384 59 of of IN cord-313694-p2sgaypq 384 60 proteins protein NNS cord-313694-p2sgaypq 384 61 Assembly Assembly NNP cord-313694-p2sgaypq 384 62 of of IN cord-313694-p2sgaypq 384 63 asparagine asparagine NN cord-313694-p2sgaypq 384 64 - - HYPH cord-313694-p2sgaypq 384 65 linked link VBN cord-313694-p2sgaypq 384 66 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 385 1 Tunicamycin Tunicamycin NNP cord-313694-p2sgaypq 385 2 inhibits inhibit VBZ cord-313694-p2sgaypq 385 3 ganglioside ganglioside NN cord-313694-p2sgaypq 385 4 biosynthesis biosynthesis NN cord-313694-p2sgaypq 385 5 in in IN cord-313694-p2sgaypq 385 6 neuronal neuronal JJ cord-313694-p2sgaypq 385 7 cells cell NNS cord-313694-p2sgaypq 386 1 Tunicamycin Tunicamycin NNP cord-313694-p2sgaypq 386 2 blocks block VBZ cord-313694-p2sgaypq 386 3 neuritogenesis neuritogenesis NN cord-313694-p2sgaypq 386 4 and and CC cord-313694-p2sgaypq 386 5 glucosamine glucosamine NN cord-313694-p2sgaypq 386 6 labeling labeling NN cord-313694-p2sgaypq 386 7 of of IN cord-313694-p2sgaypq 386 8 gangliosides ganglioside NNS cord-313694-p2sgaypq 386 9 in in IN cord-313694-p2sgaypq 386 10 developing develop VBG cord-313694-p2sgaypq 386 11 cerebral cerebral JJ cord-313694-p2sgaypq 386 12 neuron neuron NN cord-313694-p2sgaypq 386 13 cultures culture NNS cord-313694-p2sgaypq 386 14 Suppression suppression NN cord-313694-p2sgaypq 386 15 of of IN cord-313694-p2sgaypq 386 16 placental placental JJ cord-313694-p2sgaypq 386 17 alkaline alkaline JJ cord-313694-p2sgaypq 386 18 phosphatase phosphatase NN cord-313694-p2sgaypq 386 19 biosynthesis biosynthesis NN cord-313694-p2sgaypq 386 20 by by IN cord-313694-p2sgaypq 386 21 tunicamycin tunicamycin NNS cord-313694-p2sgaypq 386 22 Occurrence Occurrence NNP cord-313694-p2sgaypq 386 23 of of IN cord-313694-p2sgaypq 386 24 Nacetylglucosamine Nacetylglucosamine NNP cord-313694-p2sgaypq 386 25 - - HYPH cord-313694-p2sgaypq 386 26 l l NN cord-313694-p2sgaypq 386 27 - - HYPH cord-313694-p2sgaypq 386 28 phosphate phosphate NN cord-313694-p2sgaypq 387 1 in in IN cord-313694-p2sgaypq 387 2 proteinase proteinase NN cord-313694-p2sgaypq 388 1 I -PRON- PRP cord-313694-p2sgaypq 388 2 from from IN cord-313694-p2sgaypq 388 3 Dictyostelium Dictyostelium NNP cord-313694-p2sgaypq 388 4 discoideum discoideum NN cord-313694-p2sgaypq 388 5 Glycosylation Glycosylation NNP cord-313694-p2sgaypq 388 6 mutants mutant NNS cord-313694-p2sgaypq 388 7 of of IN cord-313694-p2sgaypq 388 8 animal animal NN cord-313694-p2sgaypq 388 9 cells cell NNS cord-313694-p2sgaypq 388 10 Laminin Laminin NNP cord-313694-p2sgaypq 388 11 , , , cord-313694-p2sgaypq 388 12 proteoglycan proteoglycan NN cord-313694-p2sgaypq 388 13 , , , cord-313694-p2sgaypq 388 14 nidogen nidogen NN cord-313694-p2sgaypq 388 15 and and CC cord-313694-p2sgaypq 388 16 collagen collagen NNP cord-313694-p2sgaypq 388 17 IV IV NNP cord-313694-p2sgaypq 388 18 : : : cord-313694-p2sgaypq 388 19 structural structural JJ cord-313694-p2sgaypq 388 20 models model NNS cord-313694-p2sgaypq 388 21 and and CC cord-313694-p2sgaypq 388 22 molecular molecular JJ cord-313694-p2sgaypq 388 23 interactions interaction NNS cord-313694-p2sgaypq 388 24 Purification purification NN cord-313694-p2sgaypq 388 25 , , , cord-313694-p2sgaypq 388 26 composition composition NN cord-313694-p2sgaypq 388 27 , , , cord-313694-p2sgaypq 388 28 molecular molecular JJ cord-313694-p2sgaypq 388 29 weight weight NN cord-313694-p2sgaypq 388 30 and and CC cord-313694-p2sgaypq 388 31 subunit subunit NN cord-313694-p2sgaypq 388 32 structure structure NN cord-313694-p2sgaypq 388 33 of of IN cord-313694-p2sgaypq 388 34 ovine ovine JJ cord-313694-p2sgaypq 388 35 submaxillary submaxillary NN cord-313694-p2sgaypq 388 36 mucin mucin NN cord-313694-p2sgaypq 388 37 Effect effect NN cord-313694-p2sgaypq 388 38 of of IN cord-313694-p2sgaypq 388 39 altered alter VBN cord-313694-p2sgaypq 388 40 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 388 41 structure structure NN cord-313694-p2sgaypq 389 1 onithe onithe NNP cord-313694-p2sgaypq 389 2 cell cell NN cord-313694-p2sgaypq 389 3 surface surface NN cord-313694-p2sgaypq 389 4 number number NN cord-313694-p2sgaypq 389 5 , , , cord-313694-p2sgaypq 389 6 distribution distribution NN cord-313694-p2sgaypq 389 7 and and CC cord-313694-p2sgaypq 389 8 turnover turnover NN cord-313694-p2sgaypq 389 9 of of IN cord-313694-p2sgaypq 389 10 the the DT cord-313694-p2sgaypq 389 11 high high JJ cord-313694-p2sgaypq 389 12 molecular molecular JJ cord-313694-p2sgaypq 389 13 weight weight NN cord-313694-p2sgaypq 389 14 acidic acidic JJ cord-313694-p2sgaypq 389 15 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 389 16 of of IN cord-313694-p2sgaypq 389 17 CHO CHO NNP cord-313694-p2sgaypq 389 18 cells cell NNS cord-313694-p2sgaypq 389 19 Preliminary preliminary JJ cord-313694-p2sgaypq 389 20 characterization characterization NN cord-313694-p2sgaypq 389 21 of of IN cord-313694-p2sgaypq 389 22 a a DT cord-313694-p2sgaypq 389 23 chinese chinese JJ cord-313694-p2sgaypq 389 24 hamster hamster NN cord-313694-p2sgaypq 389 25 ovary ovary JJ cord-313694-p2sgaypq 389 26 cell cell NN cord-313694-p2sgaypq 389 27 glycosylation glycosylation NN cord-313694-p2sgaypq 389 28 mutant mutant NN cord-313694-p2sgaypq 389 29 isolated isolate VBN cord-313694-p2sgaypq 389 30 by by IN cord-313694-p2sgaypq 389 31 screening screen VBG cord-313694-p2sgaypq 389 32 for for IN cord-313694-p2sgaypq 389 33 low low JJ cord-313694-p2sgaypq 389 34 intracellular intracellular JJ cord-313694-p2sgaypq 389 35 lysosomal lysosomal JJ cord-313694-p2sgaypq 389 36 enzyme enzyme NN cord-313694-p2sgaypq 389 37 activity activity NN cord-313694-p2sgaypq 389 38 Temporal temporal JJ cord-313694-p2sgaypq 389 39 aspects aspect NNS cord-313694-p2sgaypq 389 40 of of IN cord-313694-p2sgaypq 389 41 the the DT cord-313694-p2sgaypq 389 42 N N NNP cord-313694-p2sgaypq 389 43 - - : cord-313694-p2sgaypq 389 44 and and CC cord-313694-p2sgaypq 389 45 O o NN cord-313694-p2sgaypq 389 46 - - HYPH cord-313694-p2sgaypq 389 47 glycosylation glycosylation NN cord-313694-p2sgaypq 389 48 of of IN cord-313694-p2sgaypq 389 49 human human JJ cord-313694-p2sgaypq 389 50 chorionic chorionic JJ cord-313694-p2sgaypq 389 51 gonadotropin gonadotropin NN cord-313694-p2sgaypq 389 52 O o NN cord-313694-p2sgaypq 389 53 - - HYPH cord-313694-p2sgaypq 389 54 linked link VBN cord-313694-p2sgaypq 389 55 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 389 56 are be VBP cord-313694-p2sgaypq 389 57 acquired acquire VBN cord-313694-p2sgaypq 389 58 by by IN cord-313694-p2sgaypq 389 59 herpes herpes NNP cord-313694-p2sgaypq 389 60 simplex simplex NNP cord-313694-p2sgaypq 389 61 virus virus NN cord-313694-p2sgaypq 389 62 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 389 63 in in IN cord-313694-p2sgaypq 389 64 the the DT cord-313694-p2sgaypq 389 65 Golgi Golgi NNP cord-313694-p2sgaypq 389 66 apparatus apparatus NN cord-313694-p2sgaypq 389 67 Structural structural JJ cord-313694-p2sgaypq 389 68 and and CC cord-313694-p2sgaypq 389 69 functional functional JJ cord-313694-p2sgaypq 389 70 aspects aspect NNS cord-313694-p2sgaypq 389 71 of of IN cord-313694-p2sgaypq 389 72 tumor tumor NN cord-313694-p2sgaypq 389 73 cell cell NN cord-313694-p2sgaypq 389 74 sialomucins sialomucin NNS cord-313694-p2sgaypq 389 75 Antigenic antigenic JJ cord-313694-p2sgaypq 389 76 determinants determinant NNS cord-313694-p2sgaypq 389 77 shared share VBN cord-313694-p2sgaypq 389 78 by by IN cord-313694-p2sgaypq 389 79 lysosomal lysosomal JJ cord-313694-p2sgaypq 389 80 proteins protein NNS cord-313694-p2sgaypq 389 81 of of IN cord-313694-p2sgaypq 389 82 Dictyostelium Dictyostelium NNP cord-313694-p2sgaypq 389 83 discoideum discoideum NNP cord-313694-p2sgaypq 389 84 Adhesion adhesion NN cord-313694-p2sgaypq 389 85 mutants mutant NNS cord-313694-p2sgaypq 389 86 of of IN cord-313694-p2sgaypq 389 87 Dictyostelium Dictyostelium NNP cord-313694-p2sgaypq 389 88 disclideum disclideum NN cord-313694-p2sgaypq 389 89 lacking lack VBG cord-313694-p2sgaypq 389 90 the the DT cord-313694-p2sgaypq 389 91 saccharide saccharide JJ cord-313694-p2sgaypq 389 92 determinant determinant NN cord-313694-p2sgaypq 389 93 recognized recognize VBN cord-313694-p2sgaypq 389 94 by by IN cord-313694-p2sgaypq 389 95 two two CD cord-313694-p2sgaypq 389 96 adhesion adhesion NN cord-313694-p2sgaypq 389 97 blocking block VBG cord-313694-p2sgaypq 389 98 monoclonal monoclonal JJ cord-313694-p2sgaypq 389 99 antibodies antibody NNS cord-313694-p2sgaypq 389 100 Conformation Conformation NNP cord-313694-p2sgaypq 389 101 of of IN cord-313694-p2sgaypq 389 102 the the DT cord-313694-p2sgaypq 389 103 glycopeptide glycopeptide NN cord-313694-p2sgaypq 389 104 linkage linkage NN cord-313694-p2sgaypq 389 105 in in IN cord-313694-p2sgaypq 389 106 asparagine asparagine NN cord-313694-p2sgaypq 389 107 - - HYPH cord-313694-p2sgaypq 389 108 linked link VBN cord-313694-p2sgaypq 389 109 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 389 110 Conformation Conformation NNP cord-313694-p2sgaypq 389 111 of of IN cord-313694-p2sgaypq 389 112 the the DT cord-313694-p2sgaypq 389 113 complex complex JJ cord-313694-p2sgaypq 389 114 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 389 115 of of IN cord-313694-p2sgaypq 389 116 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 389 117 Multiple multiple JJ cord-313694-p2sgaypq 389 118 classes class NNS cord-313694-p2sgaypq 389 119 of of IN cord-313694-p2sgaypq 389 120 heparan heparan JJ cord-313694-p2sgaypq 389 121 sulfate sulfate NN cord-313694-p2sgaypq 389 122 proteoglycans proteoglycan NNS cord-313694-p2sgaypq 389 123 from from IN cord-313694-p2sgaypq 389 124 fibroblast fibroblast NN cord-313694-p2sgaypq 389 125 substratum substratum NN cord-313694-p2sgaypq 389 126 adhesion adhesion NN cord-313694-p2sgaypq 389 127 sites site NNS cord-313694-p2sgaypq 389 128 Effects effect NNS cord-313694-p2sgaypq 389 129 of of IN cord-313694-p2sgaypq 389 130 deglycosylation deglycosylation NN cord-313694-p2sgaypq 389 131 on on IN cord-313694-p2sgaypq 389 132 the the DT cord-313694-p2sgaypq 389 133 architecture architecture NN cord-313694-p2sgaypq 389 134 of of IN cord-313694-p2sgaypq 389 135 ovine ovine JJ cord-313694-p2sgaypq 389 136 submaxillary submaxillary NN cord-313694-p2sgaypq 389 137 mucin mucin NN cord-313694-p2sgaypq 389 138 glycoprotein glycoprotein NN cord-313694-p2sgaypq 389 139 Preparation preparation NN cord-313694-p2sgaypq 389 140 and and CC cord-313694-p2sgaypq 389 141 properties property NNS cord-313694-p2sgaypq 389 142 of of IN cord-313694-p2sgaypq 389 143 serum serum NN cord-313694-p2sgaypq 389 144 and and CC cord-313694-p2sgaypq 389 145 plasma plasma NN cord-313694-p2sgaypq 389 146 proteins protein NNS cord-313694-p2sgaypq 389 147 . . . cord-313694-p2sgaypq 390 1 XXIX XXIX NNP cord-313694-p2sgaypq 390 2 . . . cord-313694-p2sgaypq 391 1 Separation separation NN cord-313694-p2sgaypq 391 2 from from IN cord-313694-p2sgaypq 391 3 human human JJ cord-313694-p2sgaypq 391 4 plasma plasma NN cord-313694-p2sgaypq 391 5 of of IN cord-313694-p2sgaypq 391 6 polysaccharides polysaccharide NNS cord-313694-p2sgaypq 391 7 , , , cord-313694-p2sgaypq 391 8 peptides peptide NNS cord-313694-p2sgaypq 391 9 and and CC cord-313694-p2sgaypq 391 10 proteins protein NNS cord-313694-p2sgaypq 391 11 of of IN cord-313694-p2sgaypq 391 12 low low JJ cord-313694-p2sgaypq 391 13 molecular molecular JJ cord-313694-p2sgaypq 391 14 weight weight NN cord-313694-p2sgaypq 391 15 . . . cord-313694-p2sgaypq 392 1 Crystallization crystallization NN cord-313694-p2sgaypq 392 2 of of IN cord-313694-p2sgaypq 392 3 an an DT cord-313694-p2sgaypq 392 4 acid acid NN cord-313694-p2sgaypq 392 5 glycoprotein glycoprotein NN cord-313694-p2sgaypq 392 6 Studies Studies NNPS cord-313694-p2sgaypq 392 7 on on IN cord-313694-p2sgaypq 392 8 fetuin fetuin NNP cord-313694-p2sgaypq 392 9 , , , cord-313694-p2sgaypq 392 10 a a DT cord-313694-p2sgaypq 392 11 glycoprotein glycoprotein NN cord-313694-p2sgaypq 392 12 of of IN cord-313694-p2sgaypq 392 13 fetal fetal JJ cord-313694-p2sgaypq 392 14 serum serum NN cord-313694-p2sgaypq 392 15 . . . cord-313694-p2sgaypq 393 1 I. I. NNP cord-313694-p2sgaypq 393 2 Isolation isolation NN cord-313694-p2sgaypq 393 3 , , , cord-313694-p2sgaypq 393 4 chemical chemical NN cord-313694-p2sgaypq 393 5 composition composition NN cord-313694-p2sgaypq 393 6 , , , cord-313694-p2sgaypq 393 7 and and CC cord-313694-p2sgaypq 393 8 physicochemical physicochemical JJ cord-313694-p2sgaypq 393 9 properties property NNS cord-313694-p2sgaypq 393 10 Variation variation NN cord-313694-p2sgaypq 393 11 of of IN cord-313694-p2sgaypq 393 12 the the DT cord-313694-p2sgaypq 393 13 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 393 14 of of IN cord-313694-p2sgaypq 393 15 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 393 16 of of IN cord-313694-p2sgaypq 393 17 cells cell NNS cord-313694-p2sgaypq 393 18 growing grow VBG cord-313694-p2sgaypq 393 19 on on IN cord-313694-p2sgaypq 393 20 different different JJ cord-313694-p2sgaypq 393 21 surfaces surface NNS cord-313694-p2sgaypq 393 22 The the DT cord-313694-p2sgaypq 393 23 function function NN cord-313694-p2sgaypq 393 24 of of IN cord-313694-p2sgaypq 393 25 protein protein NN cord-313694-p2sgaypq 393 26 - - HYPH cord-313694-p2sgaypq 393 27 bound bind VBN cord-313694-p2sgaypq 393 28 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 393 29 in in IN cord-313694-p2sgaypq 393 30 normal normal JJ cord-313694-p2sgaypq 393 31 and and CC cord-313694-p2sgaypq 393 32 pathological pathological JJ cord-313694-p2sgaypq 393 33 cells cell NNS cord-313694-p2sgaypq 394 1 Asparaginyl Asparaginyl NNP cord-313694-p2sgaypq 394 2 - - HYPH cord-313694-p2sgaypq 394 3 Nacetylgalactosamine Nacetylgalactosamine NNP cord-313694-p2sgaypq 394 4 Olden Olden NNP cord-313694-p2sgaypq 394 5 K k XX cord-313694-p2sgaypq 395 1 : : : cord-313694-p2sgaypq 395 2 Retinoic retinoic JJ cord-313694-p2sgaypq 395 3 acid acid NN cord-313694-p2sgaypq 395 4 alters alter VBZ cord-313694-p2sgaypq 395 5 the the DT cord-313694-p2sgaypq 395 6 proportion proportion NN cord-313694-p2sgaypq 395 7 of of IN cord-313694-p2sgaypq 395 8 high high JJ cord-313694-p2sgaypq 395 9 mannose mannose NN cord-313694-p2sgaypq 395 10 to to IN cord-313694-p2sgaypq 395 11 complex complex JJ cord-313694-p2sgaypq 395 12 type type NN cord-313694-p2sgaypq 395 13 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 395 14 on on IN cord-313694-p2sgaypq 395 15 fibronectin fibronectin NN cord-313694-p2sgaypq 395 16 secreted secrete VBN cord-313694-p2sgaypq 395 17 by by IN cord-313694-p2sgaypq 395 18 cultured cultured JJ cord-313694-p2sgaypq 395 19 chondrocytes chondrocyte NNS cord-313694-p2sgaypq 395 20 A a DT cord-313694-p2sgaypq 395 21 temperature temperature NN cord-313694-p2sgaypq 395 22 - - HYPH cord-313694-p2sgaypq 395 23 sensitive sensitive JJ cord-313694-p2sgaypq 395 24 N n CD cord-313694-p2sgaypq 395 25 - - HYPH cord-313694-p2sgaypq 395 26 glycosylation glycosylation NN cord-313694-p2sgaypq 395 27 mutant mutant NN cord-313694-p2sgaypq 395 28 of of IN cord-313694-p2sgaypq 395 29 S. S. NNP cord-313694-p2sgaypq 395 30 cerevisiae cerevisiae NNS cord-313694-p2sgaypq 395 31 that that WDT cord-313694-p2sgaypq 395 32 behaves behave VBZ cord-313694-p2sgaypq 395 33 like like IN cord-313694-p2sgaypq 395 34 a a DT cord-313694-p2sgaypq 395 35 ceil ceil NN cord-313694-p2sgaypq 395 36 - - HYPH cord-313694-p2sgaypq 395 37 cycle cycle NN cord-313694-p2sgaypq 395 38 mutant mutant JJ cord-313694-p2sgaypq 395 39 Nglycosylation Nglycosylation NNP cord-313694-p2sgaypq 395 40 of of IN cord-313694-p2sgaypq 395 41 nascent nascent JJ cord-313694-p2sgaypq 395 42 proteins protein NNS cord-313694-p2sgaypq 395 43 early early RB cord-313694-p2sgaypq 395 44 in in IN cord-313694-p2sgaypq 395 45 the the DT cord-313694-p2sgaypq 395 46 prereplicative prereplicative JJ cord-313694-p2sgaypq 395 47 phase phase NN cord-313694-p2sgaypq 395 48 constitutes constitute VBZ cord-313694-p2sgaypq 395 49 a a DT cord-313694-p2sgaypq 395 50 process process NN cord-313694-p2sgaypq 395 51 for for IN cord-313694-p2sgaypq 395 52 controlling control VBG cord-313694-p2sgaypq 395 53 animal animal NN cord-313694-p2sgaypq 395 54 cell cell NN cord-313694-p2sgaypq 395 55 proliferation proliferation NN cord-313694-p2sgaypq 395 56 Studies study NNS cord-313694-p2sgaypq 395 57 on on IN cord-313694-p2sgaypq 395 58 the the DT cord-313694-p2sgaypq 395 59 regulation regulation NN cord-313694-p2sgaypq 395 60 of of IN cord-313694-p2sgaypq 395 61 the the DT cord-313694-p2sgaypq 395 62 biosynthesis biosynthesis NN cord-313694-p2sgaypq 395 63 of of IN cord-313694-p2sgaypq 395 64 glucose glucose NN cord-313694-p2sgaypq 395 65 - - HYPH cord-313694-p2sgaypq 395 66 containing contain VBG cord-313694-p2sgaypq 395 67 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 395 68 - - HYPH cord-313694-p2sgaypq 395 69 lipids lipid NNS cord-313694-p2sgaypq 395 70 Carbohydrate Carbohydrate NNP cord-313694-p2sgaypq 395 71 structure structure NN cord-313694-p2sgaypq 395 72 , , , cord-313694-p2sgaypq 395 73 biological biological JJ cord-313694-p2sgaypq 395 74 recognition recognition NN cord-313694-p2sgaypq 395 75 , , , cord-313694-p2sgaypq 395 76 and and CC cord-313694-p2sgaypq 395 77 immune immune JJ cord-313694-p2sgaypq 395 78 function function NN cord-313694-p2sgaypq 395 79 . . . cord-313694-p2sgaypq 396 1 In in IN cord-313694-p2sgaypq 396 2 : : : cord-313694-p2sgaypq 396 3 Ivatt Ivatt NNP cord-313694-p2sgaypq 396 4 RJ RJ NNP cord-313694-p2sgaypq 396 5 ( ( -LRB- cord-313694-p2sgaypq 396 6 Ed Ed NNP cord-313694-p2sgaypq 396 7 ) ) -RRB- cord-313694-p2sgaypq 396 8 . . . cord-313694-p2sgaypq 397 1 The the DT cord-313694-p2sgaypq 397 2 Biology Biology NNP cord-313694-p2sgaypq 397 3 of of IN cord-313694-p2sgaypq 397 4 Glycoproteins Glycoproteins NNP cord-313694-p2sgaypq 397 5 Glybopeptide Glybopeptide NNP cord-313694-p2sgaypq 397 6 changes change NNS cord-313694-p2sgaypq 397 7 and and CC cord-313694-p2sgaypq 397 8 malignant malignant JJ cord-313694-p2sgaypq 397 9 transformation transformation NN cord-313694-p2sgaypq 397 10 . . . cord-313694-p2sgaypq 398 1 A a DT cord-313694-p2sgaypq 398 2 possible possible JJ cord-313694-p2sgaypq 398 3 role role NN cord-313694-p2sgaypq 398 4 for for IN cord-313694-p2sgaypq 398 5 carbohydrate carbohydrate NN cord-313694-p2sgaypq 398 6 in in IN cord-313694-p2sgaypq 398 7 maligant maligant JJ cord-313694-p2sgaypq 398 8 behavior behavior NN cord-313694-p2sgaypq 398 9 Demonstration demonstration NN cord-313694-p2sgaypq 398 10 by by IN cord-313694-p2sgaypq 398 11 monoclonal monoclonal JJ cord-313694-p2sgaypq 398 12 antibodies antibody NNS cord-313694-p2sgaypq 398 13 that that WDT cord-313694-p2sgaypq 398 14 carbohydrate carbohydrate NN cord-313694-p2sgaypq 398 15 structures structure NNS cord-313694-p2sgaypq 398 16 of of IN cord-313694-p2sgaypq 398 17 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 398 18 and and CC cord-313694-p2sgaypq 398 19 glycolipids glycolipid NNS cord-313694-p2sgaypq 398 20 are be VBP cord-313694-p2sgaypq 398 21 onco onco JJ cord-313694-p2sgaypq 398 22 - - HYPH cord-313694-p2sgaypq 398 23 developmental developmental JJ cord-313694-p2sgaypq 398 24 antigens antigen NNS cord-313694-p2sgaypq 398 25 Glycosphingolipids Glycosphingolipids NNP cord-313694-p2sgaypq 398 26 as as IN cord-313694-p2sgaypq 398 27 differentiationdependent differentiationdependent NN cord-313694-p2sgaypq 398 28 , , , cord-313694-p2sgaypq 398 29 tumor tumor NN cord-313694-p2sgaypq 398 30 - - HYPH cord-313694-p2sgaypq 398 31 associated associate VBN cord-313694-p2sgaypq 398 32 markers marker NNS cord-313694-p2sgaypq 398 33 and and CC cord-313694-p2sgaypq 398 34 as as IN cord-313694-p2sgaypq 398 35 regulators regulator NNS cord-313694-p2sgaypq 398 36 of of IN cord-313694-p2sgaypq 398 37 cell cell NN cord-313694-p2sgaypq 398 38 proliferation proliferation NN cord-313694-p2sgaypq 398 39 Biosynthetic biosynthetic JJ cord-313694-p2sgaypq 398 40 controls control NNS cord-313694-p2sgaypq 398 41 that that WDT cord-313694-p2sgaypq 398 42 determine determine VBP cord-313694-p2sgaypq 398 43 the the DT cord-313694-p2sgaypq 398 44 branching branching NN cord-313694-p2sgaypq 398 45 and and CC cord-313694-p2sgaypq 398 46 microheterogeneity microheterogeneity NN cord-313694-p2sgaypq 398 47 of of IN cord-313694-p2sgaypq 398 48 protein protein NN cord-313694-p2sgaypq 398 49 - - HYPH cord-313694-p2sgaypq 398 50 bound bind VBN cord-313694-p2sgaypq 398 51 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 398 52 Aggregation aggregation NN cord-313694-p2sgaypq 398 53 - - HYPH cord-313694-p2sgaypq 398 54 deficient deficient JJ cord-313694-p2sgaypq 398 55 embryonal embryonal JJ cord-313694-p2sgaypq 398 56 carcinoma carcinoma NN cord-313694-p2sgaypq 398 57 cells cell NNS cord-313694-p2sgaypq 398 58 : : : cord-313694-p2sgaypq 398 59 defects defect NNS cord-313694-p2sgaypq 398 60 in in IN cord-313694-p2sgaypq 398 61 peanut peanut NN cord-313694-p2sgaypq 398 62 agglutinin agglutinin NNS cord-313694-p2sgaypq 398 63 ( ( -LRB- cord-313694-p2sgaypq 398 64 PNA PNA NNP cord-313694-p2sgaypq 398 65 ) ) -RRB- cord-313694-p2sgaypq 398 66 receptors receptor NNS cord-313694-p2sgaypq 398 67 Asparagine asparagine NN cord-313694-p2sgaypq 398 68 - - HYPH cord-313694-p2sgaypq 398 69 linked link VBN cord-313694-p2sgaypq 398 70 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 398 71 in in IN cord-313694-p2sgaypq 398 72 murine murine JJ cord-313694-p2sgaypq 398 73 tumor tumor NN cord-313694-p2sgaypq 398 74 cells cell NNS cord-313694-p2sgaypq 398 75 : : : cord-313694-p2sgaypq 398 76 comparison comparison NN cord-313694-p2sgaypq 398 77 of of IN cord-313694-p2sgaypq 398 78 a a DT cord-313694-p2sgaypq 398 79 WGA WGA NNP cord-313694-p2sgaypq 398 80 - - HYPH cord-313694-p2sgaypq 398 81 resistant resistant JJ cord-313694-p2sgaypq 398 82 ( ( -LRB- cord-313694-p2sgaypq 398 83 WGA WGA NNP cord-313694-p2sgaypq 398 84 r r NNP cord-313694-p2sgaypq 398 85 ) ) -RRB- cord-313694-p2sgaypq 398 86 nonmetastatic nonmetastatic JJ cord-313694-p2sgaypq 398 87 mutant mutant NN cord-313694-p2sgaypq 398 88 and and CC cord-313694-p2sgaypq 398 89 a a DT cord-313694-p2sgaypq 398 90 related related JJ cord-313694-p2sgaypq 398 91 WGA WGA NNP cord-313694-p2sgaypq 398 92 - - HYPH cord-313694-p2sgaypq 398 93 sensitive sensitive JJ cord-313694-p2sgaypq 398 94 ( ( -LRB- cord-313694-p2sgaypq 398 95 WGA WGA NNP cord-313694-p2sgaypq 398 96 s s POS cord-313694-p2sgaypq 398 97 ) ) -RRB- cord-313694-p2sgaypq 398 98 metastatic metastatic JJ cord-313694-p2sgaypq 398 99 line line NN cord-313694-p2sgaypq 398 100 WP WP NNP cord-313694-p2sgaypq 398 101 : : : cord-313694-p2sgaypq 398 102 Carbohydrates carbohydrate NNS cord-313694-p2sgaypq 398 103 of of IN cord-313694-p2sgaypq 398 104 the the DT cord-313694-p2sgaypq 398 105 tumor tumor NN cord-313694-p2sgaypq 398 106 cell cell NN cord-313694-p2sgaypq 398 107 surface surface NN cord-313694-p2sgaypq 398 108 Oligosaccharide oligosaccharide JJ cord-313694-p2sgaypq 398 109 modification modification NN cord-313694-p2sgaypq 398 110 by by IN cord-313694-p2sgaypq 398 111 swainsonine swainsonine JJ cord-313694-p2sgaypq 398 112 treatment treatment NN cord-313694-p2sgaypq 399 1 inhibits inhibit VBZ cord-313694-p2sgaypq 399 2 pulmonary pulmonary JJ cord-313694-p2sgaypq 399 3 colonization colonization NN cord-313694-p2sgaypq 399 4 by by IN cord-313694-p2sgaypq 399 5 B16-F10 B16-F10 NNP cord-313694-p2sgaypq 399 6 murine murine JJ cord-313694-p2sgaypq 399 7 melanoma melanoma NN cord-313694-p2sgaypq 399 8 cells cell NNS cord-313694-p2sgaypq 399 9 Regional regional JJ cord-313694-p2sgaypq 399 10 specificity specificity NN cord-313694-p2sgaypq 399 11 of of IN cord-313694-p2sgaypq 399 12 glycoconjugates glycoconjugate NNS cord-313694-p2sgaypq 399 13 in in IN cord-313694-p2sgaypq 399 14 Xenopus Xenopus NNP cord-313694-p2sgaypq 399 15 and and CC cord-313694-p2sgaypq 399 16 axolotl axolotl NN cord-313694-p2sgaypq 399 17 embryos embryo NNS cord-313694-p2sgaypq 399 18 Saccharide Saccharide NNP cord-313694-p2sgaypq 399 19 structures structure NNS cord-313694-p2sgaypq 399 20 of of IN cord-313694-p2sgaypq 399 21 the the DT cord-313694-p2sgaypq 399 22 mouse mouse NN cord-313694-p2sgaypq 399 23 embryo embryo NN cord-313694-p2sgaypq 399 24 during during IN cord-313694-p2sgaypq 399 25 the the DT cord-313694-p2sgaypq 399 26 first first JJ cord-313694-p2sgaypq 399 27 eight eight CD cord-313694-p2sgaypq 399 28 days day NNS cord-313694-p2sgaypq 399 29 of of IN cord-313694-p2sgaypq 399 30 development development NN cord-313694-p2sgaypq 399 31 Reactivity reactivity NN cord-313694-p2sgaypq 399 32 of of IN cord-313694-p2sgaypq 399 33 five five CD cord-313694-p2sgaypq 399 34 Nacetylgalactosamine Nacetylgalactosamine NNP cord-313694-p2sgaypq 399 35 - - HYPH cord-313694-p2sgaypq 399 36 recognizing recognize VBG cord-313694-p2sgaypq 399 37 lectins lectin NNS cord-313694-p2sgaypq 399 38 with with IN cord-313694-p2sgaypq 399 39 preimplantation preimplantation NN cord-313694-p2sgaypq 399 40 embryos embryo NNS cord-313694-p2sgaypq 399 41 , , , cord-313694-p2sgaypq 399 42 early early JJ cord-313694-p2sgaypq 399 43 postimplantation postimplantation NN cord-313694-p2sgaypq 399 44 embryos embryo NNS cord-313694-p2sgaypq 399 45 , , , cord-313694-p2sgaypq 399 46 and and CC cord-313694-p2sgaypq 399 47 teratocarcinoma teratocarcinoma NNP cord-313694-p2sgaypq 399 48 cells cell NNS cord-313694-p2sgaypq 399 49 of of IN cord-313694-p2sgaypq 399 50 the the DT cord-313694-p2sgaypq 399 51 mouse mouse NN cord-313694-p2sgaypq 399 52 Inhibition Inhibition NNP cord-313694-p2sgaypq 399 53 of of IN cord-313694-p2sgaypq 399 54 glycoprotein glycoprotein NN cord-313694-p2sgaypq 399 55 synthesis synthesis NN cord-313694-p2sgaypq 399 56 in in IN cord-313694-p2sgaypq 399 57 Saccharomyces Saccharomyces NNP cord-313694-p2sgaypq 399 58 cerevisiae cerevisiae NNS cord-313694-p2sgaypq 399 59 by by IN cord-313694-p2sgaypq 399 60 mating mate VBG cord-313694-p2sgaypq 399 61 pheromones pheromones NNP cord-313694-p2sgaypq 399 62 SSEA-1 SSEA-1 NNP cord-313694-p2sgaypq 399 63 , , , cord-313694-p2sgaypq 399 64 a a DT cord-313694-p2sgaypq 399 65 stagespecific stagespecific NNP cord-313694-p2sgaypq 399 66 antigen antigen NN cord-313694-p2sgaypq 399 67 of of IN cord-313694-p2sgaypq 399 68 the the DT cord-313694-p2sgaypq 399 69 mouse mouse NN cord-313694-p2sgaypq 399 70 , , , cord-313694-p2sgaypq 399 71 is be VBZ cord-313694-p2sgaypq 399 72 carried carry VBN cord-313694-p2sgaypq 399 73 by by IN cord-313694-p2sgaypq 399 74 the the DT cord-313694-p2sgaypq 399 75 glycoprotein glycoprotein NN cord-313694-p2sgaypq 399 76 - - HYPH cord-313694-p2sgaypq 399 77 bound bind VBN cord-313694-p2sgaypq 399 78 large large JJ cord-313694-p2sgaypq 399 79 carbohydrate carbohydrate NN cord-313694-p2sgaypq 399 80 in in IN cord-313694-p2sgaypq 399 81 embryonal embryonal JJ cord-313694-p2sgaypq 399 82 carcinoma carcinoma NN cord-313694-p2sgaypq 399 83 cells cell NNS cord-313694-p2sgaypq 399 84 Trypanosoma Trypanosoma NNP cord-313694-p2sgaypq 399 85 cruzi cruzi NN cord-313694-p2sgaypq 399 86 cells cell NNS cord-313694-p2sgaypq 399 87 undergo undergo VBP cord-313694-p2sgaypq 399 88 an an DT cord-313694-p2sgaypq 399 89 alteration alteration NN cord-313694-p2sgaypq 399 90 in in IN cord-313694-p2sgaypq 399 91 protein protein NN cord-313694-p2sgaypq 399 92 N n CD cord-313694-p2sgaypq 399 93 - - HYPH cord-313694-p2sgaypq 399 94 glycosylation glycosylation NN cord-313694-p2sgaypq 399 95 upon upon IN cord-313694-p2sgaypq 399 96 differentiation differentiation NN cord-313694-p2sgaypq 399 97 Appearance appearance NN cord-313694-p2sgaypq 399 98 of of IN cord-313694-p2sgaypq 399 99 a a DT cord-313694-p2sgaypq 399 100 class class NN cord-313694-p2sgaypq 399 101 of of IN cord-313694-p2sgaypq 399 102 cell cell NN cord-313694-p2sgaypq 399 103 - - HYPH cord-313694-p2sgaypq 399 104 surface surface NN cord-313694-p2sgaypq 399 105 fucosyl fucosyl NN cord-313694-p2sgaypq 399 106 - - HYPH cord-313694-p2sgaypq 399 107 glyeopeptides glyeopeptide NNS cord-313694-p2sgaypq 399 108 in in IN cord-313694-p2sgaypq 399 109 differentiated differentiated JJ cord-313694-p2sgaypq 399 110 muscle muscle NN cord-313694-p2sgaypq 399 111 cells cell NNS cord-313694-p2sgaypq 399 112 in in IN cord-313694-p2sgaypq 399 113 culture culture NN cord-313694-p2sgaypq 399 114 Changes change NNS cord-313694-p2sgaypq 399 115 in in IN cord-313694-p2sgaypq 399 116 protein protein NN cord-313694-p2sgaypq 399 117 glycosylation glycosylation NN cord-313694-p2sgaypq 399 118 during during IN cord-313694-p2sgaypq 399 119 chick chick NNP cord-313694-p2sgaypq 399 120 embryo embryo NN cord-313694-p2sgaypq 399 121 development development NN cord-313694-p2sgaypq 399 122 Changes change NNS cord-313694-p2sgaypq 399 123 in in IN cord-313694-p2sgaypq 399 124 the the DT cord-313694-p2sgaypq 399 125 expression expression NN cord-313694-p2sgaypq 399 126 of of IN cord-313694-p2sgaypq 399 127 blood blood NN cord-313694-p2sgaypq 399 128 - - HYPH cord-313694-p2sgaypq 399 129 group group NN cord-313694-p2sgaypq 399 130 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 399 131 during during IN cord-313694-p2sgaypq 399 132 oral oral JJ cord-313694-p2sgaypq 399 133 mucosal mucosal JJ cord-313694-p2sgaypq 399 134 development development NN cord-313694-p2sgaypq 399 135 in in IN cord-313694-p2sgaypq 399 136 human human JJ cord-313694-p2sgaypq 399 137 fetuses fetus NNS cord-313694-p2sgaypq 399 138 Cell Cell NNP cord-313694-p2sgaypq 399 139 surface surface NN cord-313694-p2sgaypq 399 140 glycoconjugates glycoconjugate NNS cord-313694-p2sgaypq 399 141 as as IN cord-313694-p2sgaypq 399 142 oncodifferentiation oncodifferentiation NN cord-313694-p2sgaypq 399 143 markers marker NNS cord-313694-p2sgaypq 399 144 in in IN cord-313694-p2sgaypq 399 145 hematopoietic hematopoietic JJ cord-313694-p2sgaypq 399 146 cells cell NNS cord-313694-p2sgaypq 399 147 Glycoprotein Glycoprotein NNP cord-313694-p2sgaypq 399 148 synthesis synthesis NN cord-313694-p2sgaypq 399 149 and and CC cord-313694-p2sgaypq 399 150 embryonic embryonic JJ cord-313694-p2sgaypq 399 151 development development NN cord-313694-p2sgaypq 400 1 Decreased decrease VBN cord-313694-p2sgaypq 400 2 transfer transfer NN cord-313694-p2sgaypq 400 3 of of IN cord-313694-p2sgaypq 400 4 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 400 5 from from IN cord-313694-p2sgaypq 400 6 oligosaccharideqipid oligosaccharideqipid NNP cord-313694-p2sgaypq 400 7 to to IN cord-313694-p2sgaypq 400 8 protein protein NN cord-313694-p2sgaypq 400 9 acceptors acceptor NNS cord-313694-p2sgaypq 400 10 in in IN cord-313694-p2sgaypq 400 11 regenerating regenerate VBG cord-313694-p2sgaypq 400 12 rat rat NN cord-313694-p2sgaypq 400 13 liver liver NN cord-313694-p2sgaypq 400 14 Stimulation stimulation NN cord-313694-p2sgaypq 400 15 of of IN cord-313694-p2sgaypq 400 16 lipid lipid NN cord-313694-p2sgaypq 400 17 - - HYPH cord-313694-p2sgaypq 400 18 linked link VBN cord-313694-p2sgaypq 400 19 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 400 20 assembly assembly NN cord-313694-p2sgaypq 400 21 duing due VBG cord-313694-p2sgaypq 400 22 oviduct oviduct NN cord-313694-p2sgaypq 400 23 differentiation differentiation NN cord-313694-p2sgaypq 400 24 Cell cell NN cord-313694-p2sgaypq 400 25 - - HYPH cord-313694-p2sgaypq 400 26 type type NN cord-313694-p2sgaypq 400 27 - - HYPH cord-313694-p2sgaypq 400 28 related relate VBN cord-313694-p2sgaypq 400 29 segregation segregation NN cord-313694-p2sgaypq 400 30 of of IN cord-313694-p2sgaypq 400 31 surface surface NN cord-313694-p2sgaypq 400 32 galactosyl galactosyl NN cord-313694-p2sgaypq 400 33 - - HYPH cord-313694-p2sgaypq 400 34 containing contain VBG cord-313694-p2sgaypq 400 35 components component NNS cord-313694-p2sgaypq 400 36 at at IN cord-313694-p2sgaypq 400 37 an an DT cord-313694-p2sgaypq 400 38 early early JJ cord-313694-p2sgaypq 400 39 developmental developmental JJ cord-313694-p2sgaypq 400 40 stage stage NN cord-313694-p2sgaypq 400 41 in in IN cord-313694-p2sgaypq 400 42 hemopoietic hemopoietic JJ cord-313694-p2sgaypq 400 43 bone bone NN cord-313694-p2sgaypq 400 44 marrow marrow NN cord-313694-p2sgaypq 400 45 cells cell NNS cord-313694-p2sgaypq 400 46 in in IN cord-313694-p2sgaypq 400 47 the the DT cord-313694-p2sgaypq 400 48 rabbit rabbit NN cord-313694-p2sgaypq 400 49 Changes change NNS cord-313694-p2sgaypq 400 50 in in IN cord-313694-p2sgaypq 400 51 asparagine asparagine NN cord-313694-p2sgaypq 400 52 - - HYPH cord-313694-p2sgaypq 400 53 linked link VBN cord-313694-p2sgaypq 400 54 sugar sugar NN cord-313694-p2sgaypq 400 55 chains chain NNS cord-313694-p2sgaypq 400 56 of of IN cord-313694-p2sgaypq 400 57 human human JJ cord-313694-p2sgaypq 400 58 promyelocytic promyelocytic JJ cord-313694-p2sgaypq 400 59 leukemic leukemic JJ cord-313694-p2sgaypq 400 60 cells cell NNS cord-313694-p2sgaypq 400 61 ( ( -LRB- cord-313694-p2sgaypq 400 62 HL-60 HL-60 NNP cord-313694-p2sgaypq 400 63 ) ) -RRB- cord-313694-p2sgaypq 400 64 during during IN cord-313694-p2sgaypq 400 65 monocytoid monocytoid JJ cord-313694-p2sgaypq 400 66 differentiation differentiation NN cord-313694-p2sgaypq 400 67 and and CC cord-313694-p2sgaypq 400 68 myeloid myeloid JJ cord-313694-p2sgaypq 400 69 differentiation differentiation NN cord-313694-p2sgaypq 400 70 Are be VBP cord-313694-p2sgaypq 400 71 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 400 72 and and CC cord-313694-p2sgaypq 400 73 glycosaminoglycans glycosaminoglycans NN cord-313694-p2sgaypq 400 74 components component NNS cord-313694-p2sgaypq 400 75 of of IN cord-313694-p2sgaypq 400 76 the the DT cord-313694-p2sgaypq 400 77 eukaryotic eukaryotic JJ cord-313694-p2sgaypq 400 78 genome genome NN cord-313694-p2sgaypq 400 79 ? ? . cord-313694-p2sgaypq 401 1 N n CD cord-313694-p2sgaypq 401 2 - - HYPH cord-313694-p2sgaypq 401 3 linked link VBN cord-313694-p2sgaypq 401 4 glycoprotein glycoprotein NN cord-313694-p2sgaypq 401 5 biosynthesis biosynthesis NN cord-313694-p2sgaypq 401 6 in in IN cord-313694-p2sgaypq 401 7 the the DT cord-313694-p2sgaypq 401 8 developing develop VBG cord-313694-p2sgaypq 401 9 mouse mouse NN cord-313694-p2sgaypq 401 10 embryo embryo NN cord-313694-p2sgaypq 401 11 Biological biological JJ cord-313694-p2sgaypq 401 12 significance significance NN cord-313694-p2sgaypq 401 13 of of IN cord-313694-p2sgaypq 401 14 carbohydrate carbohydrate NN cord-313694-p2sgaypq 401 15 chains chain NNS cord-313694-p2sgaypq 401 16 on on IN cord-313694-p2sgaypq 401 17 monoclonal monoclonal JJ cord-313694-p2sgaypq 401 18 antibodies antibody NNS cord-313694-p2sgaypq 402 1 A a DT cord-313694-p2sgaypq 402 2 role role NN cord-313694-p2sgaypq 402 3 for for IN cord-313694-p2sgaypq 402 4 glycosylation glycosylation NN cord-313694-p2sgaypq 402 5 of of IN cord-313694-p2sgaypq 402 6 the the DT cord-313694-p2sgaypq 402 7 c~-subunit c~-subunit NNS cord-313694-p2sgaypq 402 8 in in IN cord-313694-p2sgaypq 402 9 transduction transduction NN cord-313694-p2sgaypq 402 10 of of IN cord-313694-p2sgaypq 402 11 biological biological JJ cord-313694-p2sgaypq 402 12 signal signal NN cord-313694-p2sgaypq 402 13 in in IN cord-313694-p2sgaypq 402 14 glycoprotein glycoprotein NN cord-313694-p2sgaypq 402 15 hormones hormone NNS cord-313694-p2sgaypq 402 16 Role role NN cord-313694-p2sgaypq 402 17 of of IN cord-313694-p2sgaypq 402 18 carbohydrate carbohydrate NN cord-313694-p2sgaypq 402 19 in in IN cord-313694-p2sgaypq 402 20 human human JJ cord-313694-p2sgaypq 402 21 chorionic chorionic JJ cord-313694-p2sgaypq 402 22 gonadotropin gonadotropin NN cord-313694-p2sgaypq 402 23 Antibodies Antibodies NNPS cord-313694-p2sgaypq 402 24 against against IN cord-313694-p2sgaypq 402 25 human human JJ cord-313694-p2sgaypq 402 26 chorionic chorionic JJ cord-313694-p2sgaypq 402 27 gonadotropin gonadotropin NN cord-313694-p2sgaypq 402 28 convert convert VB cord-313694-p2sgaypq 402 29 the the DT cord-313694-p2sgaypq 402 30 deglycosylated deglycosylated JJ cord-313694-p2sgaypq 402 31 hormone hormone NN cord-313694-p2sgaypq 402 32 from from IN cord-313694-p2sgaypq 402 33 an an DT cord-313694-p2sgaypq 402 34 antagonist antagonist NN cord-313694-p2sgaypq 402 35 to to IN cord-313694-p2sgaypq 402 36 an an DT cord-313694-p2sgaypq 402 37 agonist agonist NN cord-313694-p2sgaypq 402 38 Cell cell NN cord-313694-p2sgaypq 402 39 surface surface NN cord-313694-p2sgaypq 402 40 galactosyltransferase galactosyltransferase NN cord-313694-p2sgaypq 402 41 as as IN cord-313694-p2sgaypq 402 42 a a DT cord-313694-p2sgaypq 402 43 recognition recognition NN cord-313694-p2sgaypq 402 44 molecule molecule NN cord-313694-p2sgaypq 402 45 during during IN cord-313694-p2sgaypq 402 46 development development NN cord-313694-p2sgaypq 402 47 Nelsestuen Nelsestuen NNP cord-313694-p2sgaypq 402 48 GL GL NNP cord-313694-p2sgaypq 402 49 : : : cord-313694-p2sgaypq 403 1 Deglycosylated deglycosylated JJ cord-313694-p2sgaypq 403 2 prothrombin prothrombin NN cord-313694-p2sgaypq 403 3 fragment fragment NN cord-313694-p2sgaypq 404 1 1 1 CD cord-313694-p2sgaypq 404 2 Polylactosamine Polylactosamine NNP cord-313694-p2sgaypq 404 3 glycosylation glycosylation NN cord-313694-p2sgaypq 404 4 on on IN cord-313694-p2sgaypq 404 5 human human JJ cord-313694-p2sgaypq 404 6 fetal fetal JJ cord-313694-p2sgaypq 404 7 placental placental JJ cord-313694-p2sgaypq 404 8 fibronectin fibronectin NN cord-313694-p2sgaypq 404 9 weakens weaken VBZ cord-313694-p2sgaypq 404 10 the the DT cord-313694-p2sgaypq 404 11 binding bind VBG cord-313694-p2sgaypq 404 12 affinity affinity NN cord-313694-p2sgaypq 404 13 of of IN cord-313694-p2sgaypq 404 14 fibronectin fibronectin NN cord-313694-p2sgaypq 404 15 to to IN cord-313694-p2sgaypq 404 16 gelatin gelatin NN cord-313694-p2sgaypq 404 17 Investigations investigation NNS cord-313694-p2sgaypq 404 18 of of IN cord-313694-p2sgaypq 404 19 the the DT cord-313694-p2sgaypq 404 20 possible possible JJ cord-313694-p2sgaypq 404 21 functions function NNS cord-313694-p2sgaypq 404 22 for for IN cord-313694-p2sgaypq 404 23 glycosylation glycosylation NN cord-313694-p2sgaypq 404 24 in in IN cord-313694-p2sgaypq 404 25 the the DT cord-313694-p2sgaypq 404 26 high high JJ cord-313694-p2sgaypq 404 27 mobility mobility NN cord-313694-p2sgaypq 404 28 group group NN cord-313694-p2sgaypq 404 29 proteins protein NNS cord-313694-p2sgaypq 404 30 Preferential Preferential NNP cord-313694-p2sgaypq 404 31 association association NN cord-313694-p2sgaypq 404 32 of of IN cord-313694-p2sgaypq 404 33 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 404 34 to to IN cord-313694-p2sgaypq 404 35 the the DT cord-313694-p2sgaypq 404 36 euchromatin euchromatin JJ cord-313694-p2sgaypq 404 37 regions region NNS cord-313694-p2sgaypq 404 38 of of IN cord-313694-p2sgaypq 404 39 crossfractured crossfractured JJ cord-313694-p2sgaypq 404 40 nuclei nucleus NNS cord-313694-p2sgaypq 404 41 is be VBZ cord-313694-p2sgaypq 404 42 revealed reveal VBN cord-313694-p2sgaypq 404 43 by by IN cord-313694-p2sgaypq 404 44 fracture fracture NN cord-313694-p2sgaypq 404 45 - - HYPH cord-313694-p2sgaypq 404 46 label label NN cord-313694-p2sgaypq 404 47 Eukaryotic eukaryotic JJ cord-313694-p2sgaypq 404 48 ribosomes ribosome NNS cord-313694-p2sgaypq 404 49 possess possess VBP cord-313694-p2sgaypq 404 50 a a DT cord-313694-p2sgaypq 404 51 binding binding JJ cord-313694-p2sgaypq 404 52 site site NN cord-313694-p2sgaypq 404 53 for for IN cord-313694-p2sgaypq 404 54 concanavalin concanavalin NNP cord-313694-p2sgaypq 404 55 A A NNP cord-313694-p2sgaypq 405 1 On on IN cord-313694-p2sgaypq 405 2 the the DT cord-313694-p2sgaypq 405 3 biological biological JJ cord-313694-p2sgaypq 405 4 role role NN cord-313694-p2sgaypq 405 5 of of IN cord-313694-p2sgaypq 405 6 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 405 7 The the DT cord-313694-p2sgaypq 405 8 significance significance NN cord-313694-p2sgaypq 405 9 of of IN cord-313694-p2sgaypq 405 10 glycosylated glycosylated JJ cord-313694-p2sgaypq 405 11 proteins protein NNS cord-313694-p2sgaypq 405 12 Effect Effect NNP cord-313694-p2sgaypq 405 13 of of IN cord-313694-p2sgaypq 405 14 tunicamycin tunicamycin NNS cord-313694-p2sgaypq 405 15 on on IN cord-313694-p2sgaypq 405 16 the the DT cord-313694-p2sgaypq 405 17 secretion secretion NN cord-313694-p2sgaypq 405 18 of of IN cord-313694-p2sgaypq 405 19 serum serum NN cord-313694-p2sgaypq 405 20 proteins protein NNS cord-313694-p2sgaypq 405 21 by by IN cord-313694-p2sgaypq 405 22 primary primary JJ cord-313694-p2sgaypq 405 23 cultures culture NNS cord-313694-p2sgaypq 405 24 of of IN cord-313694-p2sgaypq 405 25 rat rat NN cord-313694-p2sgaypq 405 26 and and CC cord-313694-p2sgaypq 405 27 chick chick NN cord-313694-p2sgaypq 405 28 hepatocytes hepatocyte NNS cord-313694-p2sgaypq 405 29 Differing differ VBG cord-313694-p2sgaypq 405 30 requirements requirement NNS cord-313694-p2sgaypq 405 31 for for IN cord-313694-p2sgaypq 405 32 glycosylation glycosylation NN cord-313694-p2sgaypq 405 33 in in IN cord-313694-p2sgaypq 405 34 the the DT cord-313694-p2sgaypq 405 35 secretion secretion NN cord-313694-p2sgaypq 405 36 of of IN cord-313694-p2sgaypq 405 37 related related JJ cord-313694-p2sgaypq 405 38 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 405 39 is be VBZ cord-313694-p2sgaypq 405 40 determined determine VBN cord-313694-p2sgaypq 405 41 neither neither CC cord-313694-p2sgaypq 405 42 by by IN cord-313694-p2sgaypq 405 43 the the DT cord-313694-p2sgaypq 405 44 producing produce VBG cord-313694-p2sgaypq 405 45 cell cell NN cord-313694-p2sgaypq 405 46 nor nor CC cord-313694-p2sgaypq 405 47 by by IN cord-313694-p2sgaypq 405 48 the the DT cord-313694-p2sgaypq 405 49 relative relative JJ cord-313694-p2sgaypq 405 50 number number NN cord-313694-p2sgaypq 405 51 of of IN cord-313694-p2sgaypq 405 52 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 405 53 units unit NNS cord-313694-p2sgaypq 405 54 Effect Effect NNP cord-313694-p2sgaypq 405 55 of of IN cord-313694-p2sgaypq 405 56 the the DT cord-313694-p2sgaypq 405 57 threonine threonine NN cord-313694-p2sgaypq 405 58 analog/3-hydroxynorvaline analog/3-hydroxynorvaline NN cord-313694-p2sgaypq 405 59 on on IN cord-313694-p2sgaypq 405 60 the the DT cord-313694-p2sgaypq 405 61 glycosylation glycosylation NN cord-313694-p2sgaypq 405 62 and and CC cord-313694-p2sgaypq 405 63 secretion secretion NN cord-313694-p2sgaypq 405 64 of of IN cord-313694-p2sgaypq 405 65 c c NN cord-313694-p2sgaypq 405 66 ~ ~ NFP cord-313694-p2sgaypq 405 67 l l NN cord-313694-p2sgaypq 405 68 - - HYPH cord-313694-p2sgaypq 405 69 acid acid JJ cord-313694-p2sgaypq 405 70 glycoprotein glycoprotein NN cord-313694-p2sgaypq 405 71 by by IN cord-313694-p2sgaypq 405 72 rat rat NN cord-313694-p2sgaypq 405 73 hepatocytes hepatocyte NNS cord-313694-p2sgaypq 405 74 Differential differential JJ cord-313694-p2sgaypq 405 75 effects effect NNS cord-313694-p2sgaypq 405 76 of of IN cord-313694-p2sgaypq 405 77 1-deoxynojirimycin 1-deoxynojirimycin CD cord-313694-p2sgaypq 405 78 on on IN cord-313694-p2sgaypq 405 79 the the DT cord-313694-p2sgaypq 405 80 intracellular intracellular JJ cord-313694-p2sgaypq 405 81 transport transport NN cord-313694-p2sgaypq 405 82 of of IN cord-313694-p2sgaypq 405 83 secretory secretory JJ cord-313694-p2sgaypq 405 84 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 405 85 of of IN cord-313694-p2sgaypq 405 86 human human JJ cord-313694-p2sgaypq 405 87 hePatoma hePatoma NNP cord-313694-p2sgaypq 405 88 cells cell NNS cord-313694-p2sgaypq 405 89 in in IN cord-313694-p2sgaypq 405 90 culture culture NN cord-313694-p2sgaypq 406 1 The the DT cord-313694-p2sgaypq 406 2 effects effect NNS cord-313694-p2sgaypq 406 3 of of IN cord-313694-p2sgaypq 406 4 processing processing NN cord-313694-p2sgaypq 406 5 inhibitors inhibitor NNS cord-313694-p2sgaypq 406 6 of of IN cord-313694-p2sgaypq 406 7 Nlinked Nlinked NNP cord-313694-p2sgaypq 406 8 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 406 9 on on IN cord-313694-p2sgaypq 406 10 the the DT cord-313694-p2sgaypq 406 11 intracellular intracellular JJ cord-313694-p2sgaypq 406 12 migration migration NN cord-313694-p2sgaypq 406 13 of of IN cord-313694-p2sgaypq 406 14 glycoprotein glycoprotein NN cord-313694-p2sgaypq 406 15 E2 E2 NNP cord-313694-p2sgaypq 406 16 of of IN cord-313694-p2sgaypq 406 17 mouse mouse NNP cord-313694-p2sgaypq 406 18 hepatitis hepatitis NNP cord-313694-p2sgaypq 406 19 virus virus NN cord-313694-p2sgaypq 406 20 and and CC cord-313694-p2sgaypq 406 21 the the DT cord-313694-p2sgaypq 406 22 maturation maturation NN cord-313694-p2sgaypq 406 23 of of IN cord-313694-p2sgaypq 406 24 coronavirus coronavirus NN cord-313694-p2sgaypq 406 25 particles particle NNS cord-313694-p2sgaypq 406 26 Role role NN cord-313694-p2sgaypq 406 27 of of IN cord-313694-p2sgaypq 406 28 glycosylation glycosylation NN cord-313694-p2sgaypq 406 29 in in IN cord-313694-p2sgaypq 406 30 processing processing NN cord-313694-p2sgaypq 406 31 of of IN cord-313694-p2sgaypq 406 32 newly newly RB cord-313694-p2sgaypq 406 33 translated translate VBN cord-313694-p2sgaypq 406 34 insulin insulin NN cord-313694-p2sgaypq 406 35 proreceptor proreceptor NN cord-313694-p2sgaypq 406 36 in in IN cord-313694-p2sgaypq 406 37 3T3-L1 3t3-l1 CD cord-313694-p2sgaypq 406 38 adipocytes adipocyte NNS cord-313694-p2sgaypq 406 39 Influence influence NN cord-313694-p2sgaypq 406 40 of of IN cord-313694-p2sgaypq 406 41 the the DT cord-313694-p2sgaypq 406 42 Nlinked Nlinked NNP cord-313694-p2sgaypq 406 43 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 406 44 on on IN cord-313694-p2sgaypq 406 45 the the DT cord-313694-p2sgaypq 406 46 biosynthesis biosynthesis NN cord-313694-p2sgaypq 406 47 , , , cord-313694-p2sgaypq 406 48 intracellular intracellular JJ cord-313694-p2sgaypq 406 49 routing routing NN cord-313694-p2sgaypq 406 50 , , , cord-313694-p2sgaypq 406 51 and and CC cord-313694-p2sgaypq 406 52 function function NN cord-313694-p2sgaypq 406 53 of of IN cord-313694-p2sgaypq 406 54 the the DT cord-313694-p2sgaypq 406 55 human human JJ cord-313694-p2sgaypq 406 56 asialoglycoprotein asialoglycoprotein NNP cord-313694-p2sgaypq 406 57 receptor receptor NN cord-313694-p2sgaypq 406 58 Glycosylation Glycosylation NNP cord-313694-p2sgaypq 406 59 of of IN cord-313694-p2sgaypq 406 60 the the DT cord-313694-p2sgaypq 406 61 epidermal epidermal JJ cord-313694-p2sgaypq 406 62 growth growth NN cord-313694-p2sgaypq 406 63 factor factor NN cord-313694-p2sgaypq 406 64 receptor receptor NN cord-313694-p2sgaypq 406 65 in in IN cord-313694-p2sgaypq 406 66 A-431 A-431 NNP cord-313694-p2sgaypq 406 67 cells cell NNS cord-313694-p2sgaypq 406 68 Inhibition Inhibition NNP cord-313694-p2sgaypq 406 69 of of IN cord-313694-p2sgaypq 406 70 N N NNP cord-313694-p2sgaypq 406 71 - - HYPH cord-313694-p2sgaypq 406 72 linked link VBN cord-313694-p2sgaypq 406 73 01igosaccharide 01igosaccharide JJ cord-313694-p2sgaypq 406 74 trimming trimming NN cord-313694-p2sgaypq 406 75 does do VBZ cord-313694-p2sgaypq 406 76 not not RB cord-313694-p2sgaypq 406 77 interfere interfere VB cord-313694-p2sgaypq 406 78 with with IN cord-313694-p2sgaypq 406 79 surface surface NN cord-313694-p2sgaypq 406 80 expression expression NN cord-313694-p2sgaypq 406 81 of of IN cord-313694-p2sgaypq 406 82 certain certain JJ cord-313694-p2sgaypq 406 83 integral integral JJ cord-313694-p2sgaypq 406 84 membrane membrane NN cord-313694-p2sgaypq 406 85 proteins protein NNS cord-313694-p2sgaypq 406 86 Evidence evidence NN cord-313694-p2sgaypq 406 87 for for IN cord-313694-p2sgaypq 406 88 a a DT cord-313694-p2sgaypq 406 89 glycoprotein glycoprotein NN cord-313694-p2sgaypq 406 90 ' ' `` cord-313694-p2sgaypq 406 91 signal signal NN cord-313694-p2sgaypq 406 92 ' ' '' cord-313694-p2sgaypq 406 93 involved involve VBN cord-313694-p2sgaypq 406 94 in in IN cord-313694-p2sgaypq 406 95 transport transport NN cord-313694-p2sgaypq 406 96 between between IN cord-313694-p2sgaypq 406 97 subcellular subcellular JJ cord-313694-p2sgaypq 406 98 organelles organelle NNS cord-313694-p2sgaypq 407 1 A a DT cord-313694-p2sgaypq 407 2 single single JJ cord-313694-p2sgaypq 407 3 Nlinked Nlinked NNP cord-313694-p2sgaypq 407 4 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 407 5 at at IN cord-313694-p2sgaypq 407 6 either either DT cord-313694-p2sgaypq 407 7 of of IN cord-313694-p2sgaypq 407 8 the the DT cord-313694-p2sgaypq 407 9 two two CD cord-313694-p2sgaypq 407 10 normal normal JJ cord-313694-p2sgaypq 407 11 sites site NNS cord-313694-p2sgaypq 407 12 is be VBZ cord-313694-p2sgaypq 407 13 sufficient sufficient JJ cord-313694-p2sgaypq 407 14 for for IN cord-313694-p2sgaypq 407 15 transport transport NN cord-313694-p2sgaypq 407 16 of of IN cord-313694-p2sgaypq 407 17 vesicular vesicular JJ cord-313694-p2sgaypq 407 18 stomatitis stomatitis NN cord-313694-p2sgaypq 407 19 virus virus NN cord-313694-p2sgaypq 407 20 G g NN cord-313694-p2sgaypq 407 21 protein protein NN cord-313694-p2sgaypq 407 22 to to IN cord-313694-p2sgaypq 407 23 the the DT cord-313694-p2sgaypq 407 24 cell cell NN cord-313694-p2sgaypq 407 25 surface surface NN cord-313694-p2sgaypq 408 1 The the DT cord-313694-p2sgaypq 408 2 role role NN cord-313694-p2sgaypq 408 3 of of IN cord-313694-p2sgaypq 408 4 protein protein NN cord-313694-p2sgaypq 408 5 glycosylation glycosylation NN cord-313694-p2sgaypq 408 6 in in IN cord-313694-p2sgaypq 408 7 the the DT cord-313694-p2sgaypq 408 8 compartmentalization compartmentalization NN cord-313694-p2sgaypq 408 9 and and CC cord-313694-p2sgaypq 408 10 processing processing NN cord-313694-p2sgaypq 408 11 of of IN cord-313694-p2sgaypq 408 12 mouse mouse NN cord-313694-p2sgaypq 408 13 mammary mammary JJ cord-313694-p2sgaypq 408 14 tumor tumor NN cord-313694-p2sgaypq 408 15 virus virus NN cord-313694-p2sgaypq 408 16 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 408 17 in in IN cord-313694-p2sgaypq 408 18 mouse mouse NN cord-313694-p2sgaypq 408 19 mammary mammary JJ cord-313694-p2sgaypq 408 20 tumor tumor NN cord-313694-p2sgaypq 408 21 virus virus NN cord-313694-p2sgaypq 408 22 - - HYPH cord-313694-p2sgaypq 408 23 infected infect VBN cord-313694-p2sgaypq 408 24 rat rat NN cord-313694-p2sgaypq 408 25 hepatoma hepatoma NN cord-313694-p2sgaypq 408 26 cells cell NNS cord-313694-p2sgaypq 409 1 The the DT cord-313694-p2sgaypq 409 2 formation formation NN cord-313694-p2sgaypq 409 3 of of IN cord-313694-p2sgaypq 409 4 vesicular vesicular JJ cord-313694-p2sgaypq 409 5 stomatitis stomatitis NN cord-313694-p2sgaypq 409 6 virus virus NN cord-313694-p2sgaypq 409 7 ( ( -LRB- cord-313694-p2sgaypq 409 8 San San NNP cord-313694-p2sgaypq 409 9 Juan Juan NNP cord-313694-p2sgaypq 409 10 strain strain NN cord-313694-p2sgaypq 409 11 ) ) -RRB- cord-313694-p2sgaypq 409 12 becomes become VBZ cord-313694-p2sgaypq 409 13 temperature temperature NN cord-313694-p2sgaypq 409 14 - - HYPH cord-313694-p2sgaypq 409 15 sensitive sensitive JJ cord-313694-p2sgaypq 409 16 when when WRB cord-313694-p2sgaypq 409 17 glucose glucose NN cord-313694-p2sgaypq 409 18 residues residue NNS cord-313694-p2sgaypq 409 19 are be VBP cord-313694-p2sgaypq 409 20 retained retain VBN cord-313694-p2sgaypq 409 21 on on IN cord-313694-p2sgaypq 409 22 the the DT cord-313694-p2sgaypq 409 23 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 409 24 of of IN cord-313694-p2sgaypq 409 25 the the DT cord-313694-p2sgaypq 409 26 glycoprotein glycoprotein NN cord-313694-p2sgaypq 409 27 Deletions deletion NNS cord-313694-p2sgaypq 409 28 into into IN cord-313694-p2sgaypq 409 29 a a DT cord-313694-p2sgaypq 409 30 NI NI NNP cord-313694-p2sgaypq 409 31 - - HYPH cord-313694-p2sgaypq 409 32 I2-terrninal i2-terrninal JJ cord-313694-p2sgaypq 409 33 hydrophobic hydrophobic JJ cord-313694-p2sgaypq 409 34 domain domain NN cord-313694-p2sgaypq 409 35 result result NN cord-313694-p2sgaypq 409 36 in in IN cord-313694-p2sgaypq 409 37 secretion secretion NN cord-313694-p2sgaypq 409 38 of of IN cord-313694-p2sgaypq 409 39 Rotavirus Rotavirus NNP cord-313694-p2sgaypq 409 40 VP7 vp7 NN cord-313694-p2sgaypq 409 41 , , , cord-313694-p2sgaypq 409 42 a a DT cord-313694-p2sgaypq 409 43 resident resident JJ cord-313694-p2sgaypq 409 44 endoplasmic endoplasmic NN cord-313694-p2sgaypq 409 45 reticulum reticulum NN cord-313694-p2sgaypq 409 46 membrane membrane NN cord-313694-p2sgaypq 409 47 glycoprotein glycoprotein NN cord-313694-p2sgaypq 409 48 Glycoantigen Glycoantigen NNP cord-313694-p2sgaypq 409 49 expression expression NN cord-313694-p2sgaypq 409 50 is be VBZ cord-313694-p2sgaypq 409 51 regulated regulate VBN cord-313694-p2sgaypq 409 52 both both CC cord-313694-p2sgaypq 409 53 temporally temporally RB cord-313694-p2sgaypq 409 54 and and CC cord-313694-p2sgaypq 409 55 spatially spatially RB cord-313694-p2sgaypq 409 56 during during IN cord-313694-p2sgaypq 409 57 development development NN cord-313694-p2sgaypq 409 58 in in IN cord-313694-p2sgaypq 409 59 the the DT cord-313694-p2sgaypq 409 60 cellular cellular JJ cord-313694-p2sgaypq 409 61 slime slime NN cord-313694-p2sgaypq 409 62 molds mold VBZ cord-313694-p2sgaypq 409 63 Dictyostelium Dictyostelium NNP cord-313694-p2sgaypq 409 64 discoideum discoideum NNP cord-313694-p2sgaypq 409 65 and and CC cord-313694-p2sgaypq 409 66 D. D. NNP cord-313694-p2sgaypq 409 67 mucoroides mucoroides NNP cord-313694-p2sgaypq 410 1 The the DT cord-313694-p2sgaypq 410 2 identification identification NN cord-313694-p2sgaypq 410 3 of of IN cord-313694-p2sgaypq 410 4 N n NN cord-313694-p2sgaypq 410 5 - - HYPH cord-313694-p2sgaypq 410 6 linked link VBN cord-313694-p2sgaypq 410 7 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 410 8 on on IN cord-313694-p2sgaypq 410 9 the the DT cord-313694-p2sgaypq 410 10 human human JJ cord-313694-p2sgaypq 410 11 CR2 CR2 NNP cord-313694-p2sgaypq 410 12 / / SYM cord-313694-p2sgaypq 410 13 Epstein Epstein NNP cord-313694-p2sgaypq 410 14 - - HYPH cord-313694-p2sgaypq 410 15 Barr Barr NNP cord-313694-p2sgaypq 410 16 virus virus NN cord-313694-p2sgaypq 410 17 receptor receptor NN cord-313694-p2sgaypq 410 18 and and CC cord-313694-p2sgaypq 410 19 their -PRON- PRP$ cord-313694-p2sgaypq 410 20 function function NN cord-313694-p2sgaypq 410 21 in in IN cord-313694-p2sgaypq 410 22 receptor receptor NN cord-313694-p2sgaypq 410 23 metabolism metabolism NN cord-313694-p2sgaypq 410 24 , , , cord-313694-p2sgaypq 410 25 plasma plasma NN cord-313694-p2sgaypq 410 26 membrane membrane NN cord-313694-p2sgaypq 410 27 expression expression NN cord-313694-p2sgaypq 410 28 , , , cord-313694-p2sgaypq 410 29 and and CC cord-313694-p2sgaypq 410 30 ligand ligand NN cord-313694-p2sgaypq 410 31 binding bind VBG cord-313694-p2sgaypq 410 32 Glycosylation glycosylation NN cord-313694-p2sgaypq 410 33 and and CC cord-313694-p2sgaypq 410 34 secretion secretion NN cord-313694-p2sgaypq 410 35 of of IN cord-313694-p2sgaypq 410 36 surfactant surfactant NN cord-313694-p2sgaypq 410 37 - - HYPH cord-313694-p2sgaypq 410 38 associated associate VBN cord-313694-p2sgaypq 410 39 glycoprotein glycoprotein NN cord-313694-p2sgaypq 410 40 A a DT cord-313694-p2sgaypq 410 41 Complete complete JJ cord-313694-p2sgaypq 410 42 glycosylation glycosylation NN cord-313694-p2sgaypq 410 43 of of IN cord-313694-p2sgaypq 410 44 the the DT cord-313694-p2sgaypq 410 45 insulin insulin NN cord-313694-p2sgaypq 410 46 and and CC cord-313694-p2sgaypq 410 47 insulin insulin NN cord-313694-p2sgaypq 410 48 - - HYPH cord-313694-p2sgaypq 410 49 like like JJ cord-313694-p2sgaypq 410 50 growth growth NN cord-313694-p2sgaypq 410 51 factor factor NN cord-313694-p2sgaypq 410 52 1 1 CD cord-313694-p2sgaypq 410 53 receptors receptor NNS cord-313694-p2sgaypq 410 54 is be VBZ cord-313694-p2sgaypq 410 55 not not RB cord-313694-p2sgaypq 410 56 necessary necessary JJ cord-313694-p2sgaypq 410 57 for for IN cord-313694-p2sgaypq 410 58 their -PRON- PRP$ cord-313694-p2sgaypq 410 59 biosynthesis biosynthesis NN cord-313694-p2sgaypq 410 60 and and CC cord-313694-p2sgaypq 410 61 function function VB cord-313694-p2sgaypq 410 62 Chemistry chemistry NN cord-313694-p2sgaypq 410 63 , , , cord-313694-p2sgaypq 410 64 metabolism metabolism NN cord-313694-p2sgaypq 410 65 , , , cord-313694-p2sgaypq 410 66 and and CC cord-313694-p2sgaypq 410 67 biological biological JJ cord-313694-p2sgaypq 410 68 functions function NNS cord-313694-p2sgaypq 410 69 of of IN cord-313694-p2sgaypq 410 70 sialic sialic JJ cord-313694-p2sgaypq 410 71 acids acid NNS cord-313694-p2sgaypq 410 72 Effect effect NN cord-313694-p2sgaypq 410 73 of of IN cord-313694-p2sgaypq 410 74 size size NN cord-313694-p2sgaypq 410 75 and and CC cord-313694-p2sgaypq 410 76 location location NN cord-313694-p2sgaypq 410 77 of of IN cord-313694-p2sgaypq 410 78 the the DT cord-313694-p2sgaypq 410 79 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 410 80 chain chain NN cord-313694-p2sgaypq 410 81 on on IN cord-313694-p2sgaypq 410 82 protease protease JJ cord-313694-p2sgaypq 410 83 degradation degradation NN cord-313694-p2sgaypq 410 84 of of IN cord-313694-p2sgaypq 410 85 bovine bovine JJ cord-313694-p2sgaypq 410 86 pancreatic pancreatic NN cord-313694-p2sgaypq 410 87 ribonuclease ribonuclease NN cord-313694-p2sgaypq 410 88 Swainsonine Swainsonine NNP cord-313694-p2sgaypq 410 89 inhibits inhibit VBZ cord-313694-p2sgaypq 410 90 glycoprotein glycoprotein NN cord-313694-p2sgaypq 410 91 degradation degradation NN cord-313694-p2sgaypq 410 92 by by IN cord-313694-p2sgaypq 410 93 isolated isolate VBN cord-313694-p2sgaypq 410 94 rat rat NN cord-313694-p2sgaypq 410 95 liver liver NN cord-313694-p2sgaypq 410 96 lysosomes lysosome VBZ cord-313694-p2sgaypq 410 97 Slime Slime NNP cord-313694-p2sgaypq 410 98 mold mold NN cord-313694-p2sgaypq 410 99 lectins lectin NNS cord-313694-p2sgaypq 410 100 Bacterial bacterial JJ cord-313694-p2sgaypq 410 101 glycoconjugates glycoconjugate NNS cord-313694-p2sgaypq 410 102 are be VBP cord-313694-p2sgaypq 410 103 natural natural JJ cord-313694-p2sgaypq 410 104 ligands ligand NNS cord-313694-p2sgaypq 410 105 for for IN cord-313694-p2sgaypq 410 106 the the DT cord-313694-p2sgaypq 410 107 carbohydrate carbohydrate NN cord-313694-p2sgaypq 410 108 binding binding NN cord-313694-p2sgaypq 410 109 site site NN cord-313694-p2sgaypq 410 110 of of IN cord-313694-p2sgaypq 410 111 discoidin discoidin NNP cord-313694-p2sgaypq 410 112 I -PRON- PRP cord-313694-p2sgaypq 410 113 and and CC cord-313694-p2sgaypq 410 114 influence influence VB cord-313694-p2sgaypq 410 115 its -PRON- PRP$ cord-313694-p2sgaypq 410 116 cellular cellular JJ cord-313694-p2sgaypq 410 117 compartmentalization compartmentalization NN cord-313694-p2sgaypq 410 118 Carbohydrate carbohydrate NN cord-313694-p2sgaypq 410 119 - - HYPH cord-313694-p2sgaypq 410 120 specific specific JJ cord-313694-p2sgaypq 410 121 receptors receptor NNS cord-313694-p2sgaypq 410 122 of of IN cord-313694-p2sgaypq 410 123 the the DT cord-313694-p2sgaypq 410 124 liver liver NN cord-313694-p2sgaypq 411 1 Hepatic hepatic JJ cord-313694-p2sgaypq 411 2 clearance clearance NN cord-313694-p2sgaypq 411 3 of of IN cord-313694-p2sgaypq 411 4 serum serum NN cord-313694-p2sgaypq 411 5 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 412 1 The the DT cord-313694-p2sgaypq 412 2 repair repair NN cord-313694-p2sgaypq 412 3 of of IN cord-313694-p2sgaypq 412 4 the the DT cord-313694-p2sgaypq 412 5 surface surface NN cord-313694-p2sgaypq 412 6 structure structure NN cord-313694-p2sgaypq 412 7 of of IN cord-313694-p2sgaypq 412 8 animal animal NN cord-313694-p2sgaypq 412 9 cells cell NNS cord-313694-p2sgaypq 412 10 Carbohydrate carbohydrate NN cord-313694-p2sgaypq 412 11 - - HYPH cord-313694-p2sgaypq 412 12 mediated mediate VBN cord-313694-p2sgaypq 412 13 clearance clearance NN cord-313694-p2sgaypq 412 14 of of IN cord-313694-p2sgaypq 412 15 immune immune JJ cord-313694-p2sgaypq 412 16 complexes complex NNS cord-313694-p2sgaypq 412 17 from from IN cord-313694-p2sgaypq 412 18 the the DT cord-313694-p2sgaypq 412 19 circulation circulation NN cord-313694-p2sgaypq 412 20 Carbohydrate carbohydrate NN cord-313694-p2sgaypq 412 21 - - HYPH cord-313694-p2sgaypq 412 22 mediated mediate VBN cord-313694-p2sgaypq 412 23 clearance clearance NN cord-313694-p2sgaypq 412 24 of of IN cord-313694-p2sgaypq 412 25 antibody antibody NN cord-313694-p2sgaypq 412 26 - - HYPH cord-313694-p2sgaypq 412 27 antigen antigen NN cord-313694-p2sgaypq 412 28 complexes complex NNS cord-313694-p2sgaypq 412 29 from from IN cord-313694-p2sgaypq 412 30 the the DT cord-313694-p2sgaypq 412 31 circulation circulation NN cord-313694-p2sgaypq 412 32 Surface surface NN cord-313694-p2sgaypq 412 33 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 412 34 and and CC cord-313694-p2sgaypq 412 35 surface surface NN cord-313694-p2sgaypq 412 36 lectins lectin NNS cord-313694-p2sgaypq 412 37 are be VBP cord-313694-p2sgaypq 412 38 recognition recognition NN cord-313694-p2sgaypq 412 39 determinants determinant NNS cord-313694-p2sgaypq 412 40 in in IN cord-313694-p2sgaypq 412 41 phagocytosis phagocytosis NN cord-313694-p2sgaypq 413 1 The the DT cord-313694-p2sgaypq 413 2 carbohydrate carbohydrate NN cord-313694-p2sgaypq 413 3 structure structure NN cord-313694-p2sgaypq 413 4 of of IN cord-313694-p2sgaypq 413 5 porcine porcine JJ cord-313694-p2sgaypq 413 6 uteroferrin uteroferrin NNP cord-313694-p2sgaypq 413 7 and and CC cord-313694-p2sgaypq 413 8 the the DT cord-313694-p2sgaypq 413 9 role role NN cord-313694-p2sgaypq 413 10 of of IN cord-313694-p2sgaypq 413 11 the the DT cord-313694-p2sgaypq 413 12 high high JJ cord-313694-p2sgaypq 413 13 mannose mannose NN cord-313694-p2sgaypq 413 14 chains chain NNS cord-313694-p2sgaypq 413 15 in in IN cord-313694-p2sgaypq 413 16 promoting promote VBG cord-313694-p2sgaypq 413 17 uptake uptake NN cord-313694-p2sgaypq 413 18 by by IN cord-313694-p2sgaypq 413 19 the the DT cord-313694-p2sgaypq 413 20 reticuloendothelial reticuloendothelial JJ cord-313694-p2sgaypq 413 21 cells cell NNS cord-313694-p2sgaypq 413 22 of of IN cord-313694-p2sgaypq 413 23 the the DT cord-313694-p2sgaypq 413 24 fetal fetal JJ cord-313694-p2sgaypq 413 25 liver liver NN cord-313694-p2sgaypq 414 1 Intracellular Intracellular NNP cord-313694-p2sgaypq 414 2 movement movement NN cord-313694-p2sgaypq 414 3 of of IN cord-313694-p2sgaypq 414 4 cell cell NN cord-313694-p2sgaypq 414 5 surface surface NN cord-313694-p2sgaypq 414 6 receptors receptor NNS cord-313694-p2sgaypq 414 7 after after IN cord-313694-p2sgaypq 414 8 endocytosis endocytosis NN cord-313694-p2sgaypq 414 9 : : : cord-313694-p2sgaypq 415 1 resialylation resialylation NNP cord-313694-p2sgaypq 415 2 of of IN cord-313694-p2sgaypq 415 3 asialotransferrin asialotransferrin NNP cord-313694-p2sgaypq 415 4 receptor receptor NN cord-313694-p2sgaypq 415 5 in in IN cord-313694-p2sgaypq 415 6 human human JJ cord-313694-p2sgaypq 415 7 erythroleukemia erythroleukemia NN cord-313694-p2sgaypq 415 8 cells cell VBZ cord-313694-p2sgaypq 415 9 Hyaluronic hyaluronic NN cord-313694-p2sgaypq 415 10 acid acid NN cord-313694-p2sgaypq 415 11 bonded bond VBN cord-313694-p2sgaypq 415 12 to to IN cord-313694-p2sgaypq 415 13 cell cell NN cord-313694-p2sgaypq 415 14 culture culture NN cord-313694-p2sgaypq 415 15 surfaces surface NNS cord-313694-p2sgaypq 415 16 stimulated stimulate VBD cord-313694-p2sgaypq 415 17 chondrogenesis chondrogenesis NN cord-313694-p2sgaypq 415 18 in in IN cord-313694-p2sgaypq 415 19 stage stage NN cord-313694-p2sgaypq 415 20 24 24 CD cord-313694-p2sgaypq 415 21 limb limb NN cord-313694-p2sgaypq 415 22 mesenchyme mesenchyme NNS cord-313694-p2sgaypq 415 23 cell cell NN cord-313694-p2sgaypq 415 24 cultures culture NNS cord-313694-p2sgaypq 415 25 Lectin Lectin NNP cord-313694-p2sgaypq 415 26 activation activation NN cord-313694-p2sgaypq 415 27 in in IN cord-313694-p2sgaypq 415 28 Giardia Giardia NNP cord-313694-p2sgaypq 415 29 lamblia lamblia NNP cord-313694-p2sgaypq 415 30 by by IN cord-313694-p2sgaypq 415 31 host host NN cord-313694-p2sgaypq 415 32 protease protease NN cord-313694-p2sgaypq 415 33 : : : cord-313694-p2sgaypq 415 34 A a DT cord-313694-p2sgaypq 415 35 novel novel JJ cord-313694-p2sgaypq 415 36 hostparasite hostparasite JJ cord-313694-p2sgaypq 415 37 interaction interaction NN cord-313694-p2sgaypq 415 38 Carbohydrates carbohydrate NNS cord-313694-p2sgaypq 415 39 as as IN cord-313694-p2sgaypq 415 40 recognition recognition NN cord-313694-p2sgaypq 415 41 determinants determinant NNS cord-313694-p2sgaypq 415 42 in in IN cord-313694-p2sgaypq 415 43 phagocytosis phagocytosis NN cord-313694-p2sgaypq 415 44 and and CC cord-313694-p2sgaypq 415 45 in in IN cord-313694-p2sgaypq 415 46 lectin lectin NN cord-313694-p2sgaypq 415 47 - - HYPH cord-313694-p2sgaypq 415 48 mediated mediate VBN cord-313694-p2sgaypq 415 49 killing killing NN cord-313694-p2sgaypq 415 50 of of IN cord-313694-p2sgaypq 415 51 target target NN cord-313694-p2sgaypq 415 52 cells cell NNS cord-313694-p2sgaypq 415 53 Specificity specificity NN cord-313694-p2sgaypq 415 54 of of IN cord-313694-p2sgaypq 415 55 binding binding NN cord-313694-p2sgaypq 415 56 of of IN cord-313694-p2sgaypq 415 57 a a DT cord-313694-p2sgaypq 415 58 strain strain NN cord-313694-p2sgaypq 415 59 of of IN cord-313694-p2sgaypq 415 60 uropathogenic uropathogenic JJ cord-313694-p2sgaypq 415 61 Escherichia Escherichia NNP cord-313694-p2sgaypq 415 62 coli coli NNS cord-313694-p2sgaypq 415 63 to to IN cord-313694-p2sgaypq 415 64 Galcd-4Gal Galcd-4Gal NNP cord-313694-p2sgaypq 415 65 - - HYPH cord-313694-p2sgaypq 415 66 containing contain VBG cord-313694-p2sgaypq 415 67 glycosphingolipids glycosphingolipid NNS cord-313694-p2sgaypq 415 68 Evidence evidence NN cord-313694-p2sgaypq 415 69 for for IN cord-313694-p2sgaypq 415 70 a a DT cord-313694-p2sgaypq 415 71 malarial malarial JJ cord-313694-p2sgaypq 415 72 parasite parasite NN cord-313694-p2sgaypq 415 73 interaction interaction NN cord-313694-p2sgaypq 415 74 site site NN cord-313694-p2sgaypq 415 75 on on IN cord-313694-p2sgaypq 415 76 the the DT cord-313694-p2sgaypq 415 77 major major JJ cord-313694-p2sgaypq 415 78 transmembrane transmembrane NN cord-313694-p2sgaypq 415 79 protein protein NN cord-313694-p2sgaypq 415 80 of of IN cord-313694-p2sgaypq 415 81 the the DT cord-313694-p2sgaypq 415 82 human human JJ cord-313694-p2sgaypq 415 83 erythrocyte erythrocyte NN cord-313694-p2sgaypq 415 84 Adherent Adherent NNP cord-313694-p2sgaypq 415 85 bacterial bacterial JJ cord-313694-p2sgaypq 415 86 colonization colonization NN cord-313694-p2sgaypq 415 87 in in IN cord-313694-p2sgaypq 415 88 the the DT cord-313694-p2sgaypq 415 89 pathogenesis pathogenesis NN cord-313694-p2sgaypq 415 90 of of IN cord-313694-p2sgaypq 415 91 osteomyelitis osteomyelitis NN cord-313694-p2sgaypq 415 92 Mucoproteins Mucoproteins NNP cord-313694-p2sgaypq 415 93 in in IN cord-313694-p2sgaypq 415 94 relation relation NN cord-313694-p2sgaypq 415 95 to to IN cord-313694-p2sgaypq 415 96 virus virus NN cord-313694-p2sgaypq 415 97 action action NN cord-313694-p2sgaypq 416 1 The the DT cord-313694-p2sgaypq 416 2 synthesis synthesis NN cord-313694-p2sgaypq 416 3 of of IN cord-313694-p2sgaypq 416 4 complex complex JJ cord-313694-p2sgaypq 416 5 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 416 6 by by IN cord-313694-p2sgaypq 416 7 multiglycosyltransferase multiglycosyltransferase NNP cord-313694-p2sgaypq 416 8 systems system NNS cord-313694-p2sgaypq 416 9 and and CC cord-313694-p2sgaypq 416 10 their -PRON- PRP$ cord-313694-p2sgaypq 416 11 potential potential JJ cord-313694-p2sgaypq 416 12 function function NN cord-313694-p2sgaypq 416 13 in in IN cord-313694-p2sgaypq 416 14 intercellular intercellular JJ cord-313694-p2sgaypq 416 15 adhesion adhesion NN cord-313694-p2sgaypq 417 1 The the DT cord-313694-p2sgaypq 417 2 receptor receptor NN cord-313694-p2sgaypq 417 3 function function NN cord-313694-p2sgaypq 417 4 of of IN cord-313694-p2sgaypq 417 5 galactosyltransferase galactosyltransferase NNP cord-313694-p2sgaypq 417 6 during during IN cord-313694-p2sgaypq 417 7 cellular cellular JJ cord-313694-p2sgaypq 417 8 interactions interaction NNS cord-313694-p2sgaypq 418 1 The the DT cord-313694-p2sgaypq 418 2 Biology Biology NNP cord-313694-p2sgaypq 418 3 of of IN cord-313694-p2sgaypq 418 4 Glycoproteins Glycoproteins NNP cord-313694-p2sgaypq 418 5 A A NNP cord-313694-p2sgaypq 419 1 multivalent multivalent JJ cord-313694-p2sgaypq 419 2 lacto lacto NNP cord-313694-p2sgaypq 419 3 - - HYPH cord-313694-p2sgaypq 419 4 N N NNP cord-313694-p2sgaypq 419 5 - - HYPH cord-313694-p2sgaypq 419 6 fucopentaose fucopentaose NNP cord-313694-p2sgaypq 419 7 III III NNP cord-313694-p2sgaypq 419 8 - - HYPH cord-313694-p2sgaypq 419 9 lysyllysine lysyllysine NN cord-313694-p2sgaypq 419 10 conjugate conjugate NN cord-313694-p2sgaypq 419 11 decompacts decompact VBZ cord-313694-p2sgaypq 419 12 preimplantation preimplantation NN cord-313694-p2sgaypq 419 13 mouse mouse NN cord-313694-p2sgaypq 419 14 embryos embryo NNS cord-313694-p2sgaypq 419 15 , , , cord-313694-p2sgaypq 419 16 while while IN cord-313694-p2sgaypq 419 17 the the DT cord-313694-p2sgaypq 419 18 free free JJ cord-313694-p2sgaypq 419 19 oligosaccharide oligosaccharide NN cord-313694-p2sgaypq 419 20 is be VBZ cord-313694-p2sgaypq 419 21 ineffective ineffective JJ cord-313694-p2sgaypq 419 22 Receptor Receptor NNP cord-313694-p2sgaypq 419 23 function function NN cord-313694-p2sgaypq 419 24 of of IN cord-313694-p2sgaypq 419 25 mouse mouse NN cord-313694-p2sgaypq 419 26 sperm sperm NN cord-313694-p2sgaypq 419 27 surface surface NN cord-313694-p2sgaypq 419 28 galactosyltransferase galactosyltransferase NN cord-313694-p2sgaypq 419 29 during during IN cord-313694-p2sgaypq 419 30 fertilization fertilization NN cord-313694-p2sgaypq 419 31 O o NN cord-313694-p2sgaypq 419 32 - - HYPH cord-313694-p2sgaypq 419 33 linked link VBN cord-313694-p2sgaypq 419 34 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 419 35 of of IN cord-313694-p2sgaypq 419 36 mouse mouse NN cord-313694-p2sgaypq 419 37 egg egg NN cord-313694-p2sgaypq 419 38 ZP3 zp3 WDT cord-313694-p2sgaypq 419 39 account account VBP cord-313694-p2sgaypq 419 40 for for IN cord-313694-p2sgaypq 419 41 its -PRON- PRP$ cord-313694-p2sgaypq 419 42 sperm sperm NN cord-313694-p2sgaypq 419 43 receptor receptor NN cord-313694-p2sgaypq 419 44 activity activity NN cord-313694-p2sgaypq 420 1 Differential differential JJ cord-313694-p2sgaypq 420 2 cell cell NN cord-313694-p2sgaypq 420 3 adhesion adhesion NN cord-313694-p2sgaypq 420 4 may may MD cord-313694-p2sgaypq 420 5 result result VB cord-313694-p2sgaypq 420 6 from from IN cord-313694-p2sgaypq 420 7 nonspecific nonspecific JJ cord-313694-p2sgaypq 420 8 interactions interaction NNS cord-313694-p2sgaypq 420 9 between between IN cord-313694-p2sgaypq 420 10 cell cell NN cord-313694-p2sgaypq 420 11 surface surface NN cord-313694-p2sgaypq 420 12 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 420 13 Specific specific JJ cord-313694-p2sgaypq 420 14 alteration alteration NN cord-313694-p2sgaypq 420 15 of of IN cord-313694-p2sgaypq 420 16 N N NNP cord-313694-p2sgaypq 420 17 - - HYPH cord-313694-p2sgaypq 420 18 CAM cam NN cord-313694-p2sgaypq 420 19 - - HYPH cord-313694-p2sgaypq 420 20 mediated mediate VBN cord-313694-p2sgaypq 420 21 cell cell NN cord-313694-p2sgaypq 420 22 adhesion adhesion NN cord-313694-p2sgaypq 420 23 by by IN cord-313694-p2sgaypq 420 24 an an DT cord-313694-p2sgaypq 420 25 endoneuraminidase endoneuraminidase NN cord-313694-p2sgaypq 421 1 A a DT cord-313694-p2sgaypq 421 2 heparin heparin NN cord-313694-p2sgaypq 421 3 - - HYPH cord-313694-p2sgaypq 421 4 bindifig bindifig NN cord-313694-p2sgaypq 421 5 domain domain NN cord-313694-p2sgaypq 421 6 from from IN cord-313694-p2sgaypq 421 7 N N NNP cord-313694-p2sgaypq 421 8 - - HYPH cord-313694-p2sgaypq 421 9 CAM CAM NNP cord-313694-p2sgaypq 421 10 is be VBZ cord-313694-p2sgaypq 421 11 involved involve VBN cord-313694-p2sgaypq 421 12 in in IN cord-313694-p2sgaypq 421 13 neural neural JJ cord-313694-p2sgaypq 421 14 cell cell NN cord-313694-p2sgaypq 421 15 - - HYPH cord-313694-p2sgaypq 421 16 substratum substratum NN cord-313694-p2sgaypq 421 17 adhesion adhesion NN cord-313694-p2sgaypq 421 18 Recognition Recognition NNP cord-313694-p2sgaypq 421 19 of of IN cord-313694-p2sgaypq 421 20 IgG igg NN cord-313694-p2sgaypq 421 21 by by IN cord-313694-p2sgaypq 421 22 Fc Fc NNP cord-313694-p2sgaypq 421 23 receptor receptor NN cord-313694-p2sgaypq 421 24 and and CC cord-313694-p2sgaypq 421 25 complement complement NN cord-313694-p2sgaypq 421 26 : : : cord-313694-p2sgaypq 421 27 effects effect NNS cord-313694-p2sgaypq 421 28 of of IN cord-313694-p2sgaypq 421 29 glycosidase glycosidase NN cord-313694-p2sgaypq 421 30 digestion digestion NN cord-313694-p2sgaypq 421 31 Cell cell NN cord-313694-p2sgaypq 421 32 surface surface NN cord-313694-p2sgaypq 421 33 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 421 34 in in IN cord-313694-p2sgaypq 421 35 cell cell NN cord-313694-p2sgaypq 421 36 recognition recognition NN cord-313694-p2sgaypq 421 37 and and CC cord-313694-p2sgaypq 421 38 response response NN cord-313694-p2sgaypq 421 39 Feizi Feizi NNP cord-313694-p2sgaypq 421 40 T T NNP cord-313694-p2sgaypq 421 41 : : : cord-313694-p2sgaypq 422 1 Cell cell NN cord-313694-p2sgaypq 422 2 interactions interaction NNS cord-313694-p2sgaypq 422 3 in in IN cord-313694-p2sgaypq 422 4 preimplantation preimplantation NN cord-313694-p2sgaypq 422 5 embryos embryo NNS cord-313694-p2sgaypq 422 6 : : : cord-313694-p2sgaypq 422 7 evidence evidence NN cord-313694-p2sgaypq 422 8 for for IN cord-313694-p2sgaypq 422 9 involvement involvement NN cord-313694-p2sgaypq 422 10 of of IN cord-313694-p2sgaypq 422 11 saccharides saccharide NNS cord-313694-p2sgaypq 422 12 of of IN cord-313694-p2sgaypq 422 13 the the DT cord-313694-p2sgaypq 422 14 poly poly JJ cord-313694-p2sgaypq 422 15 - - HYPH cord-313694-p2sgaypq 422 16 Nacetyllactosamine nacetyllactosamine JJ cord-313694-p2sgaypq 422 17 series series NN cord-313694-p2sgaypq 422 18 Mitochondrial mitochondrial JJ cord-313694-p2sgaypq 422 19 synthesis synthesis NN cord-313694-p2sgaypq 422 20 of of IN cord-313694-p2sgaypq 422 21 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 422 22 and and CC cord-313694-p2sgaypq 422 23 surface surface NN cord-313694-p2sgaypq 422 24 properties property NNS cord-313694-p2sgaypq 422 25 of of IN cord-313694-p2sgaypq 422 26 mitochondrial mitochondrial JJ cord-313694-p2sgaypq 422 27 membranes membrane NNS cord-313694-p2sgaypq 422 28 Cell cell NN cord-313694-p2sgaypq 422 29 membranes membrane NNS cord-313694-p2sgaypq 422 30 in in IN cord-313694-p2sgaypq 422 31 sponges sponge NNS cord-313694-p2sgaypq 423 1 The the DT cord-313694-p2sgaypq 423 2 phosphomannosyl phosphomannosyl JJ cord-313694-p2sgaypq 423 3 recognition recognition NN cord-313694-p2sgaypq 423 4 system system NN cord-313694-p2sgaypq 423 5 for for IN cord-313694-p2sgaypq 423 6 intracellular intracellular JJ cord-313694-p2sgaypq 423 7 and and CC cord-313694-p2sgaypq 423 8 intercellular intercellular JJ cord-313694-p2sgaypq 423 9 transport transport NN cord-313694-p2sgaypq 423 10 of of IN cord-313694-p2sgaypq 423 11 lysosomal lysosomal JJ cord-313694-p2sgaypq 423 12 enzymes enzyme NNS cord-313694-p2sgaypq 423 13 Cell cell NN cord-313694-p2sgaypq 423 14 - - HYPH cord-313694-p2sgaypq 423 15 cell cell NN cord-313694-p2sgaypq 423 16 recognition recognition NN cord-313694-p2sgaypq 423 17 in in IN cord-313694-p2sgaypq 423 18 yeast yeast NN cord-313694-p2sgaypq 423 19 , , , cord-313694-p2sgaypq 423 20 characterization characterization NN cord-313694-p2sgaypq 423 21 of of IN cord-313694-p2sgaypq 423 22 the the DT cord-313694-p2sgaypq 423 23 sexual sexual JJ cord-313694-p2sgaypq 423 24 agglutination agglutination NN cord-313694-p2sgaypq 423 25 factors factor NNS cord-313694-p2sgaypq 423 26 from from IN cord-313694-p2sgaypq 423 27 Saccharomyces Saccharomyces NNP cord-313694-p2sgaypq 423 28 kluyveri kluyveri VBP cord-313694-p2sgaypq 423 29 Lymphocyte Lymphocyte NNP cord-313694-p2sgaypq 423 30 attachement attachement NN cord-313694-p2sgaypq 423 31 to to IN cord-313694-p2sgaypq 423 32 high high JJ cord-313694-p2sgaypq 423 33 endothelial endothelial JJ cord-313694-p2sgaypq 423 34 venules venule NNS cord-313694-p2sgaypq 423 35 during during IN cord-313694-p2sgaypq 423 36 recirculation recirculation NN cord-313694-p2sgaypq 423 37 : : : cord-313694-p2sgaypq 423 38 a a DT cord-313694-p2sgaypq 423 39 possible possible JJ cord-313694-p2sgaypq 423 40 role role NN cord-313694-p2sgaypq 423 41 for for IN cord-313694-p2sgaypq 423 42 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 423 43 as as IN cord-313694-p2sgaypq 423 44 recognition recognition NN cord-313694-p2sgaypq 423 45 determinants determinant NNS cord-313694-p2sgaypq 423 46 Lymphocyte Lymphocyte NNP cord-313694-p2sgaypq 423 47 adhesion adhesion NN cord-313694-p2sgaypq 423 48 to to IN cord-313694-p2sgaypq 423 49 immobolized immobolized JJ cord-313694-p2sgaypq 423 50 polysaccharides polysaccharide NNS cord-313694-p2sgaypq 423 51 suggests suggest VBZ cord-313694-p2sgaypq 423 52 multiple multiple JJ cord-313694-p2sgaypq 423 53 carbohydrate carbohydrate NN cord-313694-p2sgaypq 423 54 receptors receptor NNS cord-313694-p2sgaypq 423 55 for for IN cord-313694-p2sgaypq 423 56 recirculation recirculation NN cord-313694-p2sgaypq 423 57 Spontaneous spontaneous JJ cord-313694-p2sgaypq 423 58 glycosylation glycosylation NN cord-313694-p2sgaypq 423 59 of of IN cord-313694-p2sgaypq 423 60 glycosaminoglycan glycosaminoglycan JJ cord-313694-p2sgaypq 423 61 substrates substrate NNS cord-313694-p2sgaypq 423 62 by by IN cord-313694-p2sgaypq 423 63 adherent adherent JJ cord-313694-p2sgaypq 423 64 fibroblasts fibroblast NNS cord-313694-p2sgaypq 424 1 Immunocytochemical Immunocytochemical NNP cord-313694-p2sgaypq 424 2 demonstration demonstration NN cord-313694-p2sgaypq 424 3 of of IN cord-313694-p2sgaypq 424 4 ecto ecto NNP cord-313694-p2sgaypq 424 5 - - HYPH cord-313694-p2sgaypq 424 6 galactosyltransferase galactosyltransferase NNP cord-313694-p2sgaypq 424 7 in in IN cord-313694-p2sgaypq 424 8 absorptive absorptive JJ cord-313694-p2sgaypq 424 9 intestinal intestinal JJ cord-313694-p2sgaypq 424 10 cells cell NNS cord-313694-p2sgaypq 424 11 Soluble soluble JJ cord-313694-p2sgaypq 424 12 lectins lectin NNS cord-313694-p2sgaypq 424 13 : : : cord-313694-p2sgaypq 424 14 a a DT cord-313694-p2sgaypq 424 15 new new JJ cord-313694-p2sgaypq 424 16 class class NN cord-313694-p2sgaypq 424 17 of of IN cord-313694-p2sgaypq 424 18 extraeellular extraeellular JJ cord-313694-p2sgaypq 424 19 proteins protein NNS cord-313694-p2sgaypq 424 20 Effect Effect NNP cord-313694-p2sgaypq 424 21 of of IN cord-313694-p2sgaypq 424 22 choroquine choroquine NN cord-313694-p2sgaypq 424 23 on on IN cord-313694-p2sgaypq 424 24 the the DT cord-313694-p2sgaypq 424 25 degradation degradation NN cord-313694-p2sgaypq 424 26 of of IN cord-313694-p2sgaypq 424 27 L l NN cord-313694-p2sgaypq 424 28 - - HYPH cord-313694-p2sgaypq 424 29 fucose fucose NNP cord-313694-p2sgaypq 424 30 and and CC cord-313694-p2sgaypq 424 31 the the DT cord-313694-p2sgaypq 424 32 polypeptide polypeptide NN cord-313694-p2sgaypq 424 33 moiety moiety NN cord-313694-p2sgaypq 424 34 of of IN cord-313694-p2sgaypq 424 35 plasma plasma NN cord-313694-p2sgaypq 424 36 membrane membrane NN cord-313694-p2sgaypq 424 37 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 425 1 Different different JJ cord-313694-p2sgaypq 425 2 half half RB cord-313694-p2sgaypq 425 3 - - HYPH cord-313694-p2sgaypq 425 4 lives life NNS cord-313694-p2sgaypq 425 5 of of IN cord-313694-p2sgaypq 425 6 the the DT cord-313694-p2sgaypq 425 7 carbohydrate carbohydrate NN cord-313694-p2sgaypq 425 8 and and CC cord-313694-p2sgaypq 425 9 protein protein NN cord-313694-p2sgaypq 425 10 moieties moiety NNS cord-313694-p2sgaypq 425 11 of of IN cord-313694-p2sgaypq 425 12 a a DT cord-313694-p2sgaypq 425 13 110000 110000 CD cord-313694-p2sgaypq 425 14 dalton dalton NNP cord-313694-p2sgaypq 425 15 glycoprotein glycoprotein NN cord-313694-p2sgaypq 425 16 isolated isolate VBN cord-313694-p2sgaypq 425 17 from from IN cord-313694-p2sgaypq 425 18 plasma plasma NN cord-313694-p2sgaypq 425 19 membraned membrane VBN cord-313694-p2sgaypq 425 20 of of IN cord-313694-p2sgaypq 425 21 rat rat NN cord-313694-p2sgaypq 425 22 liver liver NN cord-313694-p2sgaypq 425 23 Structural structural JJ cord-313694-p2sgaypq 425 24 determinants determinant NNS cord-313694-p2sgaypq 425 25 of of IN cord-313694-p2sgaypq 425 26 the the DT cord-313694-p2sgaypq 425 27 capacity capacity NN cord-313694-p2sgaypq 425 28 of of IN cord-313694-p2sgaypq 425 29 heparin heparin NN cord-313694-p2sgaypq 425 30 to to TO cord-313694-p2sgaypq 425 31 inhibit inhibit VB cord-313694-p2sgaypq 425 32 the the DT cord-313694-p2sgaypq 425 33 proliferation proliferation NN cord-313694-p2sgaypq 425 34 of of IN cord-313694-p2sgaypq 425 35 vascular vascular JJ cord-313694-p2sgaypq 425 36 smooth smooth JJ cord-313694-p2sgaypq 425 37 muscle muscle NN cord-313694-p2sgaypq 425 38 cells cell NNS cord-313694-p2sgaypq 425 39 . . . cord-313694-p2sgaypq 426 1 II II NNP cord-313694-p2sgaypq 426 2 . . . cord-313694-p2sgaypq 427 1 Evidence evidence NN cord-313694-p2sgaypq 427 2 for for IN cord-313694-p2sgaypq 427 3 a a DT cord-313694-p2sgaypq 427 4 pentasaccharide pentasaccharide JJ cord-313694-p2sgaypq 427 5 sequence sequence NN cord-313694-p2sgaypq 427 6 that that WDT cord-313694-p2sgaypq 427 7 contains contain VBZ cord-313694-p2sgaypq 427 8 a a DT cord-313694-p2sgaypq 427 9 3 3 CD cord-313694-p2sgaypq 427 10 - - SYM cord-313694-p2sgaypq 427 11 0-sulfate 0-sulfate CD cord-313694-p2sgaypq 427 12 group group NN cord-313694-p2sgaypq 427 13 Pathways Pathways NNPS cord-313694-p2sgaypq 427 14 of of IN cord-313694-p2sgaypq 427 15 protein protein NN cord-313694-p2sgaypq 427 16 secretion secretion NN cord-313694-p2sgaypq 427 17 in in IN cord-313694-p2sgaypq 427 18 eukaryotes eukaryote NNS cord-313694-p2sgaypq 427 19 Structure structure NN cord-313694-p2sgaypq 427 20 and and CC cord-313694-p2sgaypq 427 21 function function NN cord-313694-p2sgaypq 427 22 of of IN cord-313694-p2sgaypq 427 23 plant plant NN cord-313694-p2sgaypq 427 24 cell cell NN cord-313694-p2sgaypq 427 25 wall wall NN cord-313694-p2sgaypq 427 26 polysaccharides polysaccharide NNS cord-313694-p2sgaypq 427 27 Gangliosides Gangliosides NNP cord-313694-p2sgaypq 427 28 support support VBP cord-313694-p2sgaypq 427 29 neural neural JJ cord-313694-p2sgaypq 427 30 retina retina NN cord-313694-p2sgaypq 427 31 cell cell NN cord-313694-p2sgaypq 427 32 adhesion adhesion NN cord-313694-p2sgaypq 427 33 ~-Mannosidase-1 ~-Mannosidase-1 NFP cord-313694-p2sgaypq 427 34 mutants mutant NNS cord-313694-p2sgaypq 427 35 of of IN cord-313694-p2sgaypq 427 36 Dictyostelium Dictyostelium NNP cord-313694-p2sgaypq 427 37 discoideum discoideum NN cord-313694-p2sgaypq 427 38 : : : cord-313694-p2sgaypq 427 39 early early JJ cord-313694-p2sgaypq 427 40 aggregationessential aggregationessential NNP cord-313694-p2sgaypq 427 41 genes gene NNS cord-313694-p2sgaypq 427 42 regulate regulate VBP cord-313694-p2sgaypq 427 43 enzyme enzyme NN cord-313694-p2sgaypq 427 44 precursor precursor NN cord-313694-p2sgaypq 427 45 synthesis synthesis NN cord-313694-p2sgaypq 427 46 , , , cord-313694-p2sgaypq 427 47 modification modification NN cord-313694-p2sgaypq 427 48 , , , cord-313694-p2sgaypq 427 49 and and CC cord-313694-p2sgaypq 427 50 processing processing NN cord-313694-p2sgaypq 427 51 Discoidin Discoidin NNP cord-313694-p2sgaypq 428 1 I -PRON- PRP cord-313694-p2sgaypq 428 2 is be VBZ cord-313694-p2sgaypq 428 3 implicated implicate VBN cord-313694-p2sgaypq 428 4 in in IN cord-313694-p2sgaypq 428 5 cell cell NN cord-313694-p2sgaypq 428 6 - - HYPH cord-313694-p2sgaypq 428 7 substratum substratum NN cord-313694-p2sgaypq 428 8 attachment attachment NN cord-313694-p2sgaypq 428 9 and and CC cord-313694-p2sgaypq 428 10 ordered order VBN cord-313694-p2sgaypq 428 11 cell cell NN cord-313694-p2sgaypq 428 12 migration migration NN cord-313694-p2sgaypq 428 13 of of IN cord-313694-p2sgaypq 428 14 Dictyostelium Dictyostelium NNP cord-313694-p2sgaypq 428 15 discoideum discoideum NN cord-313694-p2sgaypq 428 16 Phenocopy Phenocopy NNP cord-313694-p2sgaypq 428 17 of of IN cord-313694-p2sgaypq 428 18 discoidin discoidin NNP cord-313694-p2sgaypq 429 1 I -PRON- PRP cord-313694-p2sgaypq 429 2 - - HYPH cord-313694-p2sgaypq 429 3 minus minus NN cord-313694-p2sgaypq 429 4 mutants mutant NNS cord-313694-p2sgaypq 429 5 by by IN cord-313694-p2sgaypq 429 6 antisense antisense NN cord-313694-p2sgaypq 429 7 transformation transformation NN cord-313694-p2sgaypq 429 8 in in IN cord-313694-p2sgaypq 429 9 Dictyostelium Dictyostelium NNP cord-313694-p2sgaypq 429 10 Mechanisms Mechanisms NNPS cord-313694-p2sgaypq 429 11 for for IN cord-313694-p2sgaypq 429 12 the the DT cord-313694-p2sgaypq 429 13 incorporation incorporation NN cord-313694-p2sgaypq 429 14 of of IN cord-313694-p2sgaypq 429 15 proteins protein NNS cord-313694-p2sgaypq 429 16 in in IN cord-313694-p2sgaypq 429 17 membranes membrane NNS cord-313694-p2sgaypq 429 18 and and CC cord-313694-p2sgaypq 429 19 organelles organelle NNS cord-313694-p2sgaypq 429 20 Glycopeptides Glycopeptides NNP cord-313694-p2sgaypq 429 21 prepared prepare VBN cord-313694-p2sgaypq 429 22 from from IN cord-313694-p2sgaypq 429 23 mouse mouse NN cord-313694-p2sgaypq 429 24 cerebrum cerebrum NNP cord-313694-p2sgaypq 429 25 inhibit inhibit VBP cord-313694-p2sgaypq 429 26 protein protein NN cord-313694-p2sgaypq 429 27 synthesis synthesis NN cord-313694-p2sgaypq 429 28 and and CC cord-313694-p2sgaypq 429 29 cell cell NN cord-313694-p2sgaypq 429 30 division division NN cord-313694-p2sgaypq 429 31 in in IN cord-313694-p2sgaypq 429 32 baby baby NN cord-313694-p2sgaypq 429 33 hamster hamster NN cord-313694-p2sgaypq 429 34 kidney kidney NN cord-313694-p2sgaypq 429 35 ceils ceil NNS cord-313694-p2sgaypq 429 36 , , , cord-313694-p2sgaypq 429 37 but but CC cord-313694-p2sgaypq 429 38 not not RB cord-313694-p2sgaypq 429 39 in in IN cord-313694-p2sgaypq 429 40 their -PRON- PRP$ cord-313694-p2sgaypq 429 41 polyoma polyoma NN cord-313694-p2sgaypq 429 42 virus virus NN cord-313694-p2sgaypq 429 43 - - HYPH cord-313694-p2sgaypq 429 44 transformed transform VBN cord-313694-p2sgaypq 429 45 analogs analog NNS cord-313694-p2sgaypq 429 46 Stereochemistry Stereochemistry NNP cord-313694-p2sgaypq 429 47 and and CC cord-313694-p2sgaypq 429 48 binding bind VBG cord-313694-p2sgaypq 429 49 behavior behavior NN cord-313694-p2sgaypq 429 50 of of IN cord-313694-p2sgaypq 429 51 carbohydrate carbohydrate NN cord-313694-p2sgaypq 429 52 chains chain NNS cord-313694-p2sgaypq 429 53 Associations Associations NNPS cord-313694-p2sgaypq 429 54 of of IN cord-313694-p2sgaypq 429 55 like like JJ cord-313694-p2sgaypq 429 56 and and CC cord-313694-p2sgaypq 429 57 unlike unlike IN cord-313694-p2sgaypq 429 58 polysaccharides polysaccharide NNS cord-313694-p2sgaypq 429 59 : : : cord-313694-p2sgaypq 429 60 mechanism mechanism NN cord-313694-p2sgaypq 429 61 and and CC cord-313694-p2sgaypq 429 62 specificity specificity NN cord-313694-p2sgaypq 429 63 in in IN cord-313694-p2sgaypq 429 64 galactomannans galactomannan NNS cord-313694-p2sgaypq 429 65 , , , cord-313694-p2sgaypq 429 66 intreacting intreacte VBG cord-313694-p2sgaypq 429 67 bacterial bacterial JJ cord-313694-p2sgaypq 429 68 polysaccharides polysaccharide NNS cord-313694-p2sgaypq 429 69 , , , cord-313694-p2sgaypq 429 70 and and CC cord-313694-p2sgaypq 429 71 related related JJ cord-313694-p2sgaypq 429 72 systems system NNS cord-313694-p2sgaypq 429 73 Model Model NNP cord-313694-p2sgaypq 429 74 for for IN cord-313694-p2sgaypq 429 75 the the DT cord-313694-p2sgaypq 429 76 structure structure NN cord-313694-p2sgaypq 429 77 of of IN cord-313694-p2sgaypq 429 78 the the DT cord-313694-p2sgaypq 429 79 gastric gastric JJ cord-313694-p2sgaypq 429 80 mucous mucous JJ cord-313694-p2sgaypq 429 81 gel gel NN cord-313694-p2sgaypq 429 82 Freeze freeze NN cord-313694-p2sgaypq 429 83 HH hh NN cord-313694-p2sgaypq 429 84 : : : cord-313694-p2sgaypq 429 85 Interaction Interaction NNP cord-313694-p2sgaypq 429 86 of of IN cord-313694-p2sgaypq 429 87 Dictyostelium Dictyostelium NNP cord-313694-p2sgaypq 429 88 discoideum discoideum NN cord-313694-p2sgaypq 429 89 lysosomal lysosomal NN cord-313694-p2sgaypq 429 90 enzymes enzyme NNS cord-313694-p2sgaypq 429 91 with with IN cord-313694-p2sgaypq 429 92 the the DT cord-313694-p2sgaypq 429 93 mammalian mammalian JJ cord-313694-p2sgaypq 429 94 phosphomannosyl phosphomannosyl NN cord-313694-p2sgaypq 429 95 receptor receptor NN cord-313694-p2sgaypq 429 96 Differential Differential NNP cord-313694-p2sgaypq 429 97 processing processing NN cord-313694-p2sgaypq 429 98 of of IN cord-313694-p2sgaypq 429 99 asn asn NN cord-313694-p2sgaypq 429 100 - - HYPH cord-313694-p2sgaypq 429 101 linked link VBN cord-313694-p2sgaypq 429 102 oligisaccharides oligisaccharide NNS cord-313694-p2sgaypq 429 103 on on IN cord-313694-p2sgaypq 429 104 pituitary pituitary JJ cord-313694-p2sgaypq 429 105 glycoprotein glycoprotein NN cord-313694-p2sgaypq 429 106 hormones hormone NNS cord-313694-p2sgaypq 429 107 : : : cord-313694-p2sgaypq 429 108 implications implication NNS cord-313694-p2sgaypq 429 109 for for IN cord-313694-p2sgaypq 429 110 biologic biologic JJ cord-313694-p2sgaypq 429 111 function function NN cord-313694-p2sgaypq 430 1 Lysosomal Lysosomal NNP cord-313694-p2sgaypq 430 2 enzyme enzyme VBZ cord-313694-p2sgaypq 430 3 bind!ng bind!ng NNP cord-313694-p2sgaypq 430 4 to to TO cord-313694-p2sgaypq 430 5 mouse mouse VB cord-313694-p2sgaypq 430 6 P388D P388D NNP cord-313694-p2sgaypq 430 7 l l NNP cord-313694-p2sgaypq 430 8 macrophage macrophage NN cord-313694-p2sgaypq 430 9 membranes membrane NNS cord-313694-p2sgaypq 430 10 lacking lack VBG cord-313694-p2sgaypq 430 11 the the DT cord-313694-p2sgaypq 430 12 215-kDa 215-kda JJ cord-313694-p2sgaypq 430 13 mannose mannose NN cord-313694-p2sgaypq 430 14 6-phosphate 6-phosphate NN cord-313694-p2sgaypq 430 15 receptor receptor NN cord-313694-p2sgaypq 430 16 : : : cord-313694-p2sgaypq 430 17 evidence evidence NN cord-313694-p2sgaypq 430 18 for for IN cord-313694-p2sgaypq 430 19 the the DT cord-313694-p2sgaypq 430 20 existence existence NN cord-313694-p2sgaypq 430 21 of of IN cord-313694-p2sgaypq 430 22 a a DT cord-313694-p2sgaypq 430 23 second second JJ cord-313694-p2sgaypq 430 24 mannose mannose NN cord-313694-p2sgaypq 430 25 6-phosphate 6-phosphate NN cord-313694-p2sgaypq 430 26 receptor receptor NN cord-313694-p2sgaypq 430 27 Identification identification NN cord-313694-p2sgaypq 430 28 and and CC cord-313694-p2sgaypq 430 29 characterization characterization NN cord-313694-p2sgaypq 430 30 of of IN cord-313694-p2sgaypq 430 31 cells cell NNS cord-313694-p2sgaypq 430 32 deficient deficient JJ cord-313694-p2sgaypq 430 33 in in IN cord-313694-p2sgaypq 430 34 the the DT cord-313694-p2sgaypq 430 35 mannose mannose NN cord-313694-p2sgaypq 430 36 6-phosphate 6-phosphate NN cord-313694-p2sgaypq 430 37 receptor receptor NN cord-313694-p2sgaypq 430 38 : : : cord-313694-p2sgaypq 430 39 evidence evidence NN cord-313694-p2sgaypq 430 40 for for IN cord-313694-p2sgaypq 430 41 an an DT cord-313694-p2sgaypq 430 42 alternate alternate JJ cord-313694-p2sgaypq 430 43 pathway pathway NN cord-313694-p2sgaypq 430 44 for for IN cord-313694-p2sgaypq 430 45 lysosomal lysosomal JJ cord-313694-p2sgaypq 430 46 enzyme enzyme NN cord-313694-p2sgaypq 430 47 targetting targette VBG cord-313694-p2sgaypq 430 48 Variability variability NN cord-313694-p2sgaypq 430 49 in in IN cord-313694-p2sgaypq 430 50 transport transport NN cord-313694-p2sgaypq 430 51 rates rate NNS cord-313694-p2sgaypq 430 52 of of IN cord-313694-p2sgaypq 430 53 secretory secretory JJ cord-313694-p2sgaypq 430 54 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 430 55 through through IN cord-313694-p2sgaypq 430 56 the the DT cord-313694-p2sgaypq 430 57 endoplasmic endoplasmic NN cord-313694-p2sgaypq 430 58 reticulum reticulum NN cord-313694-p2sgaypq 430 59 and and CC cord-313694-p2sgaypq 430 60 Golgi Golgi NNP cord-313694-p2sgaypq 430 61 in in IN cord-313694-p2sgaypq 430 62 human human JJ cord-313694-p2sgaypq 430 63 hepatoma hepatoma NN cord-313694-p2sgaypq 430 64 cells cell VBZ cord-313694-p2sgaypq 430 65 Glucose glucose NN cord-313694-p2sgaypq 430 66 phosphotransferase phosphotransferase NN cord-313694-p2sgaypq 430 67 and and CC cord-313694-p2sgaypq 430 68 intracellular intracellular JJ cord-313694-p2sgaypq 430 69 protein protein NN cord-313694-p2sgaypq 430 70 trafficking trafficking NN cord-313694-p2sgaypq 430 71 Freeze freeze NN cord-313694-p2sgaypq 430 72 HH HH NNP cord-313694-p2sgaypq 430 73 : : : cord-313694-p2sgaypq 431 1 Modifications modification NNS cord-313694-p2sgaypq 431 2 of of IN cord-313694-p2sgaypq 431 3 lysosomal lysosomal JJ cord-313694-p2sgaypq 431 4 enzymes enzyme NNS cord-313694-p2sgaypq 431 5 in in IN cord-313694-p2sgaypq 431 6 Dictyostelium Dictyostelium NNP cord-313694-p2sgaypq 431 7 discoideum discoideum NN cord-313694-p2sgaypq 431 8 Glucose Glucose NNP cord-313694-p2sgaypq 431 9 removal removal NN cord-313694-p2sgaypq 431 10 from from IN cord-313694-p2sgaypq 431 11 N n NN cord-313694-p2sgaypq 431 12 - - HYPH cord-313694-p2sgaypq 431 13 linked link VBN cord-313694-p2sgaypq 431 14 oligosaccharides oligosaccharide NNS cord-313694-p2sgaypq 431 15 is be VBZ cord-313694-p2sgaypq 431 16 required require VBN cord-313694-p2sgaypq 431 17 for for IN cord-313694-p2sgaypq 431 18 efficient efficient JJ cord-313694-p2sgaypq 431 19 maturation maturation NN cord-313694-p2sgaypq 431 20 of of IN cord-313694-p2sgaypq 431 21 cerain cerain JJ cord-313694-p2sgaypq 431 22 secretory secretory JJ cord-313694-p2sgaypq 431 23 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 431 24 from from IN cord-313694-p2sgaypq 431 25 the the DT cord-313694-p2sgaypq 431 26 rough rough JJ cord-313694-p2sgaypq 431 27 endoplasmic endoplasmic NN cord-313694-p2sgaypq 431 28 reticulum reticulum NN cord-313694-p2sgaypq 431 29 to to IN cord-313694-p2sgaypq 431 30 the the DT cord-313694-p2sgaypq 431 31 golgi golgi NN cord-313694-p2sgaypq 431 32 complex complex JJ cord-313694-p2sgaypq 431 33 Deletion deletion NN cord-313694-p2sgaypq 431 34 of of IN cord-313694-p2sgaypq 431 35 clustered clustered JJ cord-313694-p2sgaypq 431 36 O o NN cord-313694-p2sgaypq 431 37 - - HYPH cord-313694-p2sgaypq 431 38 linked link VBN cord-313694-p2sgaypq 431 39 carbohydrates carbohydrate NNS cord-313694-p2sgaypq 431 40 does do VBZ cord-313694-p2sgaypq 431 41 not not RB cord-313694-p2sgaypq 431 42 impair impair VB cord-313694-p2sgaypq 431 43 function function NN cord-313694-p2sgaypq 431 44 of of IN cord-313694-p2sgaypq 431 45 low low JJ cord-313694-p2sgaypq 431 46 density density NN cord-313694-p2sgaypq 431 47 lipoprotein lipoprotein NN cord-313694-p2sgaypq 431 48 receptor receptor NN cord-313694-p2sgaypq 431 49 in in IN cord-313694-p2sgaypq 431 50 transfected transfecte VBN cord-313694-p2sgaypq 431 51 fibroblasts fibroblast NNS cord-313694-p2sgaypq 432 1 Absence absence NN cord-313694-p2sgaypq 432 2 of of IN cord-313694-p2sgaypq 432 3 a a DT cord-313694-p2sgaypq 432 4 carbohydrate carbohydrate NN cord-313694-p2sgaypq 432 5 modification modification NN cord-313694-p2sgaypq 432 6 does do VBZ cord-313694-p2sgaypq 432 7 not not RB cord-313694-p2sgaypq 432 8 affect affect VB cord-313694-p2sgaypq 432 9 the the DT cord-313694-p2sgaypq 432 10 level level NN cord-313694-p2sgaypq 432 11 or or CC cord-313694-p2sgaypq 432 12 the the DT cord-313694-p2sgaypq 432 13 subcellular subcellular JJ cord-313694-p2sgaypq 432 14 175 175 CD cord-313694-p2sgaypq 432 15 . . . cord-313694-p2sgaypq 433 1 176 176 CD cord-313694-p2sgaypq 433 2 . . . cord-313694-p2sgaypq 434 1 177 177 CD cord-313694-p2sgaypq 434 2 . . . cord-313694-p2sgaypq 435 1 localization localization NN cord-313694-p2sgaypq 435 2 of of IN cord-313694-p2sgaypq 435 3 three three CD cord-313694-p2sgaypq 435 4 membrane membrane NN cord-313694-p2sgaypq 435 5 glycoproteins glycoprotein NNS cord-313694-p2sgaypq 435 6 in in IN cord-313694-p2sgaypq 435 7 modB modb JJ cord-313694-p2sgaypq 435 8 mutants mutant NNS cord-313694-p2sgaypq 435 9 of of IN cord-313694-p2sgaypq 435 10 Dictyostelium Dictyostelium NNP cord-313694-p2sgaypq 435 11 discoideum discoideum NN cord-313694-p2sgaypq 435 12 Reversible reversible JJ cord-313694-p2sgaypq 435 13 defects defect NNS cord-313694-p2sgaypq 435 14 in in IN cord-313694-p2sgaypq 435 15 O o NN cord-313694-p2sgaypq 435 16 - - HYPH cord-313694-p2sgaypq 435 17 linked link VBN cord-313694-p2sgaypq 435 18 glycosylation glycosylation NN cord-313694-p2sgaypq 435 19 and and CC cord-313694-p2sgaypq 435 20 LDL ldl NN cord-313694-p2sgaypq 435 21 receptor receptor NN cord-313694-p2sgaypq 435 22 expression expression NN cord-313694-p2sgaypq 435 23 in in IN cord-313694-p2sgaypq 435 24 a a DT cord-313694-p2sgaypq 435 25 UDP udp NN cord-313694-p2sgaypq 435 26 - - HYPH cord-313694-p2sgaypq 435 27 Gal gal NN cord-313694-p2sgaypq 435 28 / / SYM cord-313694-p2sgaypq 435 29 UDP udp NN cord-313694-p2sgaypq 435 30 - - HYPH cord-313694-p2sgaypq 435 31 GalNAc galnac NN cord-313694-p2sgaypq 435 32 4-epimerase 4-epimerase CD cord-313694-p2sgaypq 435 33 deficient deficient JJ cord-313694-p2sgaypq 435 34 mutant mutant JJ cord-313694-p2sgaypq 435 35 Groth Groth NNP cord-313694-p2sgaypq 435 36 SF SF NNP cord-313694-p2sgaypq 435 37 : : : cord-313694-p2sgaypq 435 38 Studies study NNS cord-313694-p2sgaypq 435 39 on on IN cord-313694-p2sgaypq 435 40 mucoproteins mucoprotein NNS cord-313694-p2sgaypq 435 41 . . . cord-313694-p2sgaypq 436 1 III III NNP cord-313694-p2sgaypq 436 2 . . . cord-313694-p2sgaypq 437 1 The the DT cord-313694-p2sgaypq 437 2 accesibility accesibility NN cord-313694-p2sgaypq 437 3 to to IN cord-313694-p2sgaypq 437 4 trypsin trypsin NN cord-313694-p2sgaypq 437 5 of of IN cord-313694-p2sgaypq 437 6 the the DT cord-313694-p2sgaypq 437 7 susceptible susceptible JJ cord-313694-p2sgaypq 437 8 bonds bond NNS cord-313694-p2sgaypq 437 9 in in IN cord-313694-p2sgaypq 437 10 ovine ovine JJ cord-313694-p2sgaypq 437 11 submaxillary submaxillary NN cord-313694-p2sgaypq 437 12 land land NN cord-313694-p2sgaypq 437 13 mucoproteins mucoproteins NNP cord-313694-p2sgaypq 437 14 Influenza Influenza NNP cord-313694-p2sgaypq 437 15 C C NNP cord-313694-p2sgaypq 437 16 virus virus NN cord-313694-p2sgaypq 437 17 uses use VBZ cord-313694-p2sgaypq 437 18 9 9 CD cord-313694-p2sgaypq 437 19 - - HYPH cord-313694-p2sgaypq 437 20 0-Acetyl 0-acetyl CD cord-313694-p2sgaypq 437 21 - - HYPH cord-313694-p2sgaypq 437 22 N N NNP cord-313694-p2sgaypq 437 23 - - HYPH cord-313694-p2sgaypq 437 24 Acetylneuraminic Acetylneuraminic NNP cord-313694-p2sgaypq 437 25 Acid Acid NNP cord-313694-p2sgaypq 437 26 as as IN cord-313694-p2sgaypq 437 27 a a DT cord-313694-p2sgaypq 437 28 high high JJ cord-313694-p2sgaypq 437 29 affinity affinity NN cord-313694-p2sgaypq 437 30 receptor receptor NN cord-313694-p2sgaypq 437 31 determinant determinant NN cord-313694-p2sgaypq 437 32 for for IN cord-313694-p2sgaypq 437 33 attachment attachment NN cord-313694-p2sgaypq 437 34 to to TO cord-313694-p2sgaypq 437 35 cells cells VB cord-313694-p2sgaypq 437 36 Carbohydrate carbohydrate NN cord-313694-p2sgaypq 437 37 - - HYPH cord-313694-p2sgaypq 437 38 binding bind VBG cord-313694-p2sgaypq 437 39 sites site NNS cord-313694-p2sgaypq 437 40 of of IN cord-313694-p2sgaypq 437 41 the the DT cord-313694-p2sgaypq 437 42 mannose mannose NN cord-313694-p2sgaypq 437 43 - - HYPH cord-313694-p2sgaypq 437 44 specific specific JJ cord-313694-p2sgaypq 437 45 fimbrial fimbrial JJ cord-313694-p2sgaypq 437 46 lectins lectin NNS cord-313694-p2sgaypq 437 47 of of IN cord-313694-p2sgaypq 437 48 enterobacteria enterobacteria NNP cord-313694-p2sgaypq 437 49 The the DT cord-313694-p2sgaypq 437 50 mouse mouse NN cord-313694-p2sgaypq 437 51 egg egg NN cord-313694-p2sgaypq 437 52 's 's POS cord-313694-p2sgaypq 437 53 receptor receptor NN cord-313694-p2sgaypq 437 54 for for IN cord-313694-p2sgaypq 437 55 sperm sperm NN cord-313694-p2sgaypq 437 56 ; ; : cord-313694-p2sgaypq 437 57 What what WP cord-313694-p2sgaypq 437 58 is be VBZ cord-313694-p2sgaypq 437 59 it -PRON- PRP cord-313694-p2sgaypq 437 60 and and CC cord-313694-p2sgaypq 437 61 how how WRB cord-313694-p2sgaypq 437 62 does do VBZ cord-313694-p2sgaypq 437 63 it -PRON- PRP cord-313694-p2sgaypq 437 64 work work VB cord-313694-p2sgaypq 437 65 ? ? . cord-313694-p2sgaypq 438 1 Cell cell NN cord-313694-p2sgaypq 438 2 adhesion adhesion NN cord-313694-p2sgaypq 438 3 molecules molecule NNS cord-313694-p2sgaypq 439 1 Neuronal neuronal JJ cord-313694-p2sgaypq 439 2 cell cell NN cord-313694-p2sgaypq 439 3 - - HYPH cord-313694-p2sgaypq 439 4 cell cell NN cord-313694-p2sgaypq 439 5 adhesion adhesion NN cord-313694-p2sgaypq 439 6 depends depend VBZ cord-313694-p2sgaypq 439 7 on on IN cord-313694-p2sgaypq 439 8 interactions interaction NNS cord-313694-p2sgaypq 439 9 of of IN cord-313694-p2sgaypq 439 10 N N NNP cord-313694-p2sgaypq 439 11 - - HYPH cord-313694-p2sgaypq 439 12 CAM cam NN cord-313694-p2sgaypq 439 13 with with IN cord-313694-p2sgaypq 439 14 heparin heparin NN cord-313694-p2sgaypq 439 15 - - HYPH cord-313694-p2sgaypq 439 16 like like JJ cord-313694-p2sgaypq 439 17 molecules molecule NNS cord-313694-p2sgaypq 439 18 Reconstitution reconstitution NN cord-313694-p2sgaypq 439 19 of of IN cord-313694-p2sgaypq 439 20 high high JJ cord-313694-p2sgaypq 439 21 cell cell NN cord-313694-p2sgaypq 439 22 binding bind VBG cord-313694-p2sgaypq 439 23 affinity affinity NN cord-313694-p2sgaypq 439 24 of of IN cord-313694-p2sgaypq 439 25 a a DT cord-313694-p2sgaypq 439 26 marine marine JJ cord-313694-p2sgaypq 439 27 sponge sponge NN cord-313694-p2sgaypq 439 28 aggregation aggregation NN cord-313694-p2sgaypq 439 29 factor factor NN cord-313694-p2sgaypq 439 30 by by IN cord-313694-p2sgaypq 439 31 cross cross NN cord-313694-p2sgaypq 439 32 - - NN cord-313694-p2sgaypq 439 33 linking linking NN cord-313694-p2sgaypq 439 34 of of IN cord-313694-p2sgaypq 439 35 small small JJ cord-313694-p2sgaypq 439 36 low low JJ cord-313694-p2sgaypq 439 37 affinity affinity NN cord-313694-p2sgaypq 439 38 fragments fragment NNS cord-313694-p2sgaypq 439 39 into into IN cord-313694-p2sgaypq 439 40 a a DT cord-313694-p2sgaypq 439 41 large large JJ cord-313694-p2sgaypq 439 42 polyvalent polyvalent JJ cord-313694-p2sgaypq 439 43 polymer polymer NN cord-313694-p2sgaypq 439 44 Localization Localization NNP cord-313694-p2sgaypq 439 45 of of IN cord-313694-p2sgaypq 439 46 galactosyl galactosyl NNP cord-313694-p2sgaypq 439 47 - - : cord-313694-p2sgaypq 439 48 and and CC cord-313694-p2sgaypq 439 49 sialyltransferase sialyltransferase NNP cord-313694-p2sgaypq 439 50 by by IN cord-313694-p2sgaypq 439 51 immunofluorescence immunofluorescence NN cord-313694-p2sgaypq 439 52 : : : cord-313694-p2sgaypq 439 53 evidence evidence NN cord-313694-p2sgaypq 439 54 for for IN cord-313694-p2sgaypq 439 55 different different JJ cord-313694-p2sgaypq 439 56 sites site NNS cord-313694-p2sgaypq 439 57 Outer outer JJ cord-313694-p2sgaypq 439 58 membrane membrane NN cord-313694-p2sgaypq 439 59 terminal terminal NN cord-313694-p2sgaypq 439 60 saccharide saccharide NN cord-313694-p2sgaypq 439 61 of of IN cord-313694-p2sgaypq 439 62 bovine bovine JJ cord-313694-p2sgaypq 439 63 liver liver NN cord-313694-p2sgaypq 439 64 nuclei nucleus NNS cord-313694-p2sgaypq 439 65 and and CC cord-313694-p2sgaypq 439 66 mitochondria mitochondrion NNS cord-313694-p2sgaypq 439 67 Hendil Hendil NNP cord-313694-p2sgaypq 439 68 KB KB NNP cord-313694-p2sgaypq 439 69 : : : cord-313694-p2sgaypq 440 1 Ion ion NN cord-313694-p2sgaypq 440 2 exchange exchange NN cord-313694-p2sgaypq 440 3 properties property NNS cord-313694-p2sgaypq 440 4 of of IN cord-313694-p2sgaypq 440 5 the the DT cord-313694-p2sgaypq 440 6 glycocalyx glycocalyx NNP cord-313694-p2sgaypq 440 7 of of IN cord-313694-p2sgaypq 440 8 the the DT cord-313694-p2sgaypq 440 9 amoeba amoeba NNP cord-313694-p2sgaypq 440 10 Chaos Chaos NNP cord-313694-p2sgaypq 440 11 chaos chaos NN cord-313694-p2sgaypq 440 12 and and CC cord-313694-p2sgaypq 440 13 its -PRON- PRP$ cord-313694-p2sgaypq 440 14 relation relation NN cord-313694-p2sgaypq 440 15 to to IN cord-313694-p2sgaypq 440 16 pinocytosis pinocytosis NNP cord-313694-p2sgaypq 440 17 Liver liver NN cord-313694-p2sgaypq 440 18 endothelium endothelium NN cord-313694-p2sgaypq 440 19 mediates mediate VBZ cord-313694-p2sgaypq 440 20 the the DT cord-313694-p2sgaypq 440 21 hepatocyte hepatocyte NN cord-313694-p2sgaypq 440 22 's 's POS cord-313694-p2sgaypq 440 23 uptake uptake NN cord-313694-p2sgaypq 440 24 of of IN cord-313694-p2sgaypq 440 25 ceruloplasmin ceruloplasmin NNP cord-313694-p2sgaypq 441 1 The the DT cord-313694-p2sgaypq 441 2 molecular molecular JJ cord-313694-p2sgaypq 441 3 basis basis NN cord-313694-p2sgaypq 441 4 of of IN cord-313694-p2sgaypq 441 5 species species NN cord-313694-p2sgaypq 441 6 specific specific JJ cord-313694-p2sgaypq 441 7 cell cell NN cord-313694-p2sgaypq 441 8 - - HYPH cord-313694-p2sgaypq 441 9 cell cell NN cord-313694-p2sgaypq 441 10 recognition recognition NN cord-313694-p2sgaypq 441 11 in in IN cord-313694-p2sgaypq 441 12 marine marine JJ cord-313694-p2sgaypq 441 13 sponges sponge NNS cord-313694-p2sgaypq 441 14 , , , cord-313694-p2sgaypq 441 15 and and CC cord-313694-p2sgaypq 441 16 a a DT cord-313694-p2sgaypq 441 17 study study NN cord-313694-p2sgaypq 441 18 on on IN cord-313694-p2sgaypq 441 19 organogenesis organogenesi NNS cord-313694-p2sgaypq 441 20 during during IN cord-313694-p2sgaypq 441 21 metamorphosis metamorphosis NN cord-313694-p2sgaypq 441 22 Rous rous JJ cord-313694-p2sgaypq 441 23 sarcoma sarcoma NN cord-313694-p2sgaypq 441 24 virus virus NN cord-313694-p2sgaypq 441 25 - - HYPH cord-313694-p2sgaypq 441 26 transformed transform VBN cord-313694-p2sgaypq 441 27 baby baby NN cord-313694-p2sgaypq 441 28 hamster hamster NN cord-313694-p2sgaypq 441 29 kidney kidney NN cord-313694-p2sgaypq 441 30 cells cell NNS cord-313694-p2sgaypq 441 31 express express VBP cord-313694-p2sgaypq 441 32 higher high JJR cord-313694-p2sgaypq 441 33 levels level NNS cord-313694-p2sgaypq 441 34 of of IN cord-313694-p2sgaypq 441 35 asparagine asparagine NN cord-313694-p2sgaypq 441 36 - - HYPH cord-313694-p2sgaypq 441 37 linked link VBN cord-313694-p2sgaypq 441 38 tri tri NN cord-313694-p2sgaypq 441 39 - - HYPH cord-313694-p2sgaypq 441 40 and and CC cord-313694-p2sgaypq 441 41 tetraantennary tetraantennary NNP cord-313694-p2sgaypq 441 42 glycopeptides glycopeptides NNP cord-313694-p2sgaypq 441 43 containing contain VBG cord-313694-p2sgaypq 441 44 [ [ -LRB- cord-313694-p2sgaypq 441 45 GlcNAc-13(1,6)Man GlcNAc-13(1,6)Man NNP cord-313694-p2sgaypq 441 46 - - HYPH cord-313694-p2sgaypq 441 47 a(1,6)Man a(1,6)Man NNP cord-313694-p2sgaypq 441 48 ] ] -RRB- cord-313694-p2sgaypq 441 49 and and CC cord-313694-p2sgaypq 441 50 poly poly JJ cord-313694-p2sgaypq 441 51 - - HYPH cord-313694-p2sgaypq 441 52 Nacetyllactosamine nacetyllactosamine JJ cord-313694-p2sgaypq 441 53 sequences sequence NNS cord-313694-p2sgaypq 441 54 than than IN cord-313694-p2sgaypq 441 55 baby baby NN cord-313694-p2sgaypq 441 56 hamster hamster NN cord-313694-p2sgaypq 441 57 kidney kidney NN cord-313694-p2sgaypq 441 58 cells cell NNS cord-313694-p2sgaypq 442 1 I -PRON- PRP cord-313694-p2sgaypq 442 2 am be VBP cord-313694-p2sgaypq 442 3 grateful grateful JJ cord-313694-p2sgaypq 442 4 to to IN cord-313694-p2sgaypq 442 5 Drs Drs NNP cord-313694-p2sgaypq 442 6 . . . cord-313694-p2sgaypq 443 1 C. C. NNP cord-313694-p2sgaypq 443 2 Feldherr Feldherr NNP cord-313694-p2sgaypq 443 3 and and CC cord-313694-p2sgaypq 443 4 G. G. NNP cord-313694-p2sgaypq 443 5 Erdos Erdos NNP cord-313694-p2sgaypq 443 6 for for IN cord-313694-p2sgaypq 443 7 their -PRON- PRP$ cord-313694-p2sgaypq 443 8 critisms critism NNS cord-313694-p2sgaypq 443 9 of of IN cord-313694-p2sgaypq 443 10 the the DT cord-313694-p2sgaypq 443 11 manuscript manuscript NN cord-313694-p2sgaypq 443 12 during during IN cord-313694-p2sgaypq 443 13 preparation preparation NN cord-313694-p2sgaypq 443 14 . . .