id	sid	tid	token	lemma	pos
cord-310192-8x37nx4s	1	1	key	key	JJ
cord-310192-8x37nx4s	1	2	:	:	:
cord-310192-8x37nx4s	1	3	cord-310192	cord-310192	NN
cord-310192-8x37nx4s	1	4	-	-	HYPH
cord-310192-8x37nx4s	1	5	8x37nx4s	8x37nx4s	CD
cord-310192-8x37nx4s	1	6	authors	author	NNS
cord-310192-8x37nx4s	1	7	:	:	:
cord-310192-8x37nx4s	1	8	Zhang	Zhang	NNP
cord-310192-8x37nx4s	1	9	,	,	,
cord-310192-8x37nx4s	1	10	Huaqun	Huaqun	NNP
cord-310192-8x37nx4s	1	11	;	;	:
cord-310192-8x37nx4s	1	12	Keane	Keane	NNP
cord-310192-8x37nx4s	1	13	,	,	,
cord-310192-8x37nx4s	1	14	Sarah	Sarah	NNP
cord-310192-8x37nx4s	1	15	C.	C.	NNP
cord-310192-8x37nx4s	1	16	title	title	NN
cord-310192-8x37nx4s	1	17	:	:	:
cord-310192-8x37nx4s	1	18	Advances	advance	NNS
cord-310192-8x37nx4s	1	19	that	that	WDT
cord-310192-8x37nx4s	1	20	facilitate	facilitate	VBP
cord-310192-8x37nx4s	1	21	the	the	DT
cord-310192-8x37nx4s	1	22	study	study	NN
cord-310192-8x37nx4s	1	23	of	of	IN
cord-310192-8x37nx4s	1	24	large	large	JJ
cord-310192-8x37nx4s	1	25	RNA	RNA	NNP
cord-310192-8x37nx4s	1	26	structure	structure	NN
cord-310192-8x37nx4s	1	27	and	and	CC
cord-310192-8x37nx4s	1	28	dynamics	dynamic	NNS
cord-310192-8x37nx4s	1	29	by	by	IN
cord-310192-8x37nx4s	1	30	nuclear	nuclear	JJ
cord-310192-8x37nx4s	1	31	magnetic	magnetic	JJ
cord-310192-8x37nx4s	1	32	resonance	resonance	NN
cord-310192-8x37nx4s	1	33	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	1	34	date	date	NN
cord-310192-8x37nx4s	1	35	:	:	:
cord-310192-8x37nx4s	1	36	2019	2019	CD
cord-310192-8x37nx4s	1	37	-	-	HYPH
cord-310192-8x37nx4s	1	38	04	04	CD
cord-310192-8x37nx4s	1	39	-	-	SYM
cord-310192-8x37nx4s	1	40	25	25	CD
cord-310192-8x37nx4s	1	41	journal	journal	NN
cord-310192-8x37nx4s	1	42	:	:	:
cord-310192-8x37nx4s	2	1	Wiley	Wiley	NNP
cord-310192-8x37nx4s	2	2	Interdiscip	Interdiscip	NNP
cord-310192-8x37nx4s	2	3	Rev	Rev	NNP
cord-310192-8x37nx4s	2	4	RNA	RNA	NNP
cord-310192-8x37nx4s	2	5	DOI	DOI	NNP
cord-310192-8x37nx4s	2	6	:	:	:
cord-310192-8x37nx4s	2	7	10.1002	10.1002	CD
cord-310192-8x37nx4s	2	8	/	/	SYM
cord-310192-8x37nx4s	2	9	wrna.1541	wrna.1541	NNP
cord-310192-8x37nx4s	3	1	sha	sha	NNP
cord-310192-8x37nx4s	4	1	:	:	:
cord-310192-8x37nx4s	4	2	752647712df63469695dca93754b85b2c3862344	752647712df63469695dca93754b85b2c3862344	.
cord-310192-8x37nx4s	5	1	doc_id	doc_id	CD
cord-310192-8x37nx4s	5	2	:	:	:
cord-310192-8x37nx4s	6	1	310192	310192	CD
cord-310192-8x37nx4s	6	2	cord_uid	cord_uid	NNS
cord-310192-8x37nx4s	6	3	:	:	:
cord-310192-8x37nx4s	7	1	8x37nx4s	8x37nx4s	CD
cord-310192-8x37nx4s	7	2	The	the	DT
cord-310192-8x37nx4s	7	3	characterization	characterization	NN
cord-310192-8x37nx4s	7	4	of	of	IN
cord-310192-8x37nx4s	7	5	functional	functional	JJ
cord-310192-8x37nx4s	7	6	yet	yet	RB
cord-310192-8x37nx4s	7	7	nonprotein	nonprotein	NNP
cord-310192-8x37nx4s	7	8	coding	code	VBG
cord-310192-8x37nx4s	7	9	(	(	-LRB-
cord-310192-8x37nx4s	7	10	nc	nc	NNP
cord-310192-8x37nx4s	7	11	)	)	-RRB-
cord-310192-8x37nx4s	7	12	RNAs	RNAs	NNP
cord-310192-8x37nx4s	7	13	has	have	VBZ
cord-310192-8x37nx4s	7	14	expanded	expand	VBN
cord-310192-8x37nx4s	7	15	the	the	DT
cord-310192-8x37nx4s	7	16	role	role	NN
cord-310192-8x37nx4s	7	17	of	of	IN
cord-310192-8x37nx4s	7	18	RNA	RNA	NNP
cord-310192-8x37nx4s	7	19	in	in	IN
cord-310192-8x37nx4s	7	20	the	the	DT
cord-310192-8x37nx4s	7	21	cell	cell	NN
cord-310192-8x37nx4s	7	22	from	from	IN
cord-310192-8x37nx4s	7	23	a	a	DT
cord-310192-8x37nx4s	7	24	passive	passive	JJ
cord-310192-8x37nx4s	7	25	player	player	NN
cord-310192-8x37nx4s	7	26	in	in	IN
cord-310192-8x37nx4s	7	27	the	the	DT
cord-310192-8x37nx4s	7	28	central	central	JJ
cord-310192-8x37nx4s	7	29	dogma	dogma	NN
cord-310192-8x37nx4s	7	30	of	of	IN
cord-310192-8x37nx4s	7	31	molecular	molecular	JJ
cord-310192-8x37nx4s	7	32	biology	biology	NN
cord-310192-8x37nx4s	7	33	to	to	IN
cord-310192-8x37nx4s	7	34	an	an	DT
cord-310192-8x37nx4s	7	35	active	active	JJ
cord-310192-8x37nx4s	7	36	regulator	regulator	NN
cord-310192-8x37nx4s	7	37	of	of	IN
cord-310192-8x37nx4s	7	38	gene	gene	NN
cord-310192-8x37nx4s	7	39	expression	expression	NN
cord-310192-8x37nx4s	7	40	.	.	.
cord-310192-8x37nx4s	8	1	The	the	DT
cord-310192-8x37nx4s	8	2	misregulation	misregulation	NN
cord-310192-8x37nx4s	8	3	of	of	IN
cord-310192-8x37nx4s	8	4	ncRNA	ncrna	CD
cord-310192-8x37nx4s	8	5	function	function	NN
cord-310192-8x37nx4s	8	6	has	have	VBZ
cord-310192-8x37nx4s	8	7	been	be	VBN
cord-310192-8x37nx4s	8	8	linked	link	VBN
cord-310192-8x37nx4s	8	9	with	with	IN
cord-310192-8x37nx4s	8	10	a	a	DT
cord-310192-8x37nx4s	8	11	variety	variety	NN
cord-310192-8x37nx4s	8	12	of	of	IN
cord-310192-8x37nx4s	8	13	diseases	disease	NNS
cord-310192-8x37nx4s	8	14	and	and	CC
cord-310192-8x37nx4s	8	15	disorders	disorder	NNS
cord-310192-8x37nx4s	8	16	ranging	range	VBG
cord-310192-8x37nx4s	8	17	from	from	IN
cord-310192-8x37nx4s	8	18	cancers	cancer	NNS
cord-310192-8x37nx4s	8	19	to	to	IN
cord-310192-8x37nx4s	8	20	neurodegeneration	neurodegeneration	NN
cord-310192-8x37nx4s	8	21	.	.	.
cord-310192-8x37nx4s	9	1	However	however	RB
cord-310192-8x37nx4s	9	2	,	,	,
cord-310192-8x37nx4s	9	3	a	a	DT
cord-310192-8x37nx4s	9	4	detailed	detailed	JJ
cord-310192-8x37nx4s	9	5	molecular	molecular	JJ
cord-310192-8x37nx4s	9	6	understanding	understanding	NN
cord-310192-8x37nx4s	9	7	of	of	IN
cord-310192-8x37nx4s	9	8	how	how	WRB
cord-310192-8x37nx4s	9	9	ncRNAs	ncRNAs	NNP
cord-310192-8x37nx4s	9	10	function	function	NN
cord-310192-8x37nx4s	9	11	has	have	VBZ
cord-310192-8x37nx4s	9	12	been	be	VBN
cord-310192-8x37nx4s	9	13	limited	limit	VBN
cord-310192-8x37nx4s	9	14	;	;	:
cord-310192-8x37nx4s	9	15	due	due	JJ
cord-310192-8x37nx4s	9	16	,	,	,
cord-310192-8x37nx4s	9	17	in	in	IN
cord-310192-8x37nx4s	9	18	part	part	NN
cord-310192-8x37nx4s	9	19	,	,	,
cord-310192-8x37nx4s	9	20	to	to	IN
cord-310192-8x37nx4s	9	21	the	the	DT
cord-310192-8x37nx4s	9	22	difficulties	difficulty	NNS
cord-310192-8x37nx4s	9	23	associated	associate	VBN
cord-310192-8x37nx4s	9	24	with	with	IN
cord-310192-8x37nx4s	9	25	obtaining	obtain	VBG
cord-310192-8x37nx4s	9	26	high‐resolution	high‐resolution	NNP
cord-310192-8x37nx4s	9	27	structures	structure	NNS
cord-310192-8x37nx4s	9	28	of	of	IN
cord-310192-8x37nx4s	9	29	large	large	JJ
cord-310192-8x37nx4s	9	30	RNAs	rna	NNS
cord-310192-8x37nx4s	9	31	.	.	.
cord-310192-8x37nx4s	10	1	Tertiary	tertiary	JJ
cord-310192-8x37nx4s	10	2	structure	structure	NN
cord-310192-8x37nx4s	10	3	determination	determination	NN
cord-310192-8x37nx4s	10	4	of	of	IN
cord-310192-8x37nx4s	10	5	RNA	RNA	NNP
cord-310192-8x37nx4s	10	6	as	as	IN
cord-310192-8x37nx4s	10	7	a	a	DT
cord-310192-8x37nx4s	10	8	whole	whole	NN
cord-310192-8x37nx4s	10	9	is	be	VBZ
cord-310192-8x37nx4s	10	10	hampered	hamper	VBN
cord-310192-8x37nx4s	10	11	by	by	IN
cord-310192-8x37nx4s	10	12	various	various	JJ
cord-310192-8x37nx4s	10	13	technical	technical	JJ
cord-310192-8x37nx4s	10	14	challenges	challenge	NNS
cord-310192-8x37nx4s	10	15	,	,	,
cord-310192-8x37nx4s	10	16	all	all	DT
cord-310192-8x37nx4s	10	17	of	of	IN
cord-310192-8x37nx4s	10	18	which	which	WDT
cord-310192-8x37nx4s	10	19	are	be	VBP
cord-310192-8x37nx4s	10	20	exacerbated	exacerbate	VBN
cord-310192-8x37nx4s	10	21	as	as	IN
cord-310192-8x37nx4s	10	22	the	the	DT
cord-310192-8x37nx4s	10	23	size	size	NN
cord-310192-8x37nx4s	10	24	of	of	IN
cord-310192-8x37nx4s	10	25	the	the	DT
cord-310192-8x37nx4s	10	26	RNA	RNA	NNP
cord-310192-8x37nx4s	10	27	increases	increase	NNS
cord-310192-8x37nx4s	10	28	.	.	.
cord-310192-8x37nx4s	11	1	Namely	namely	RB
cord-310192-8x37nx4s	11	2	,	,	,
cord-310192-8x37nx4s	11	3	RNAs	rna	NNS
cord-310192-8x37nx4s	11	4	tend	tend	VBP
cord-310192-8x37nx4s	11	5	to	to	TO
cord-310192-8x37nx4s	11	6	be	be	VB
cord-310192-8x37nx4s	11	7	highly	highly	RB
cord-310192-8x37nx4s	11	8	flexible	flexible	JJ
cord-310192-8x37nx4s	11	9	and	and	CC
cord-310192-8x37nx4s	11	10	dynamic	dynamic	JJ
cord-310192-8x37nx4s	11	11	molecules	molecule	NNS
cord-310192-8x37nx4s	11	12	,	,	,
cord-310192-8x37nx4s	11	13	which	which	WDT
cord-310192-8x37nx4s	11	14	are	be	VBP
cord-310192-8x37nx4s	11	15	difficult	difficult	JJ
cord-310192-8x37nx4s	11	16	to	to	TO
cord-310192-8x37nx4s	11	17	crystallize	crystallize	VB
cord-310192-8x37nx4s	11	18	.	.	.
cord-310192-8x37nx4s	12	1	Biomolecular	biomolecular	JJ
cord-310192-8x37nx4s	12	2	nuclear	nuclear	JJ
cord-310192-8x37nx4s	12	3	magnetic	magnetic	JJ
cord-310192-8x37nx4s	12	4	resonance	resonance	NN
cord-310192-8x37nx4s	12	5	(	(	-LRB-
cord-310192-8x37nx4s	12	6	NMR	NMR	NNP
cord-310192-8x37nx4s	12	7	)	)	-RRB-
cord-310192-8x37nx4s	12	8	spectroscopy	spectroscopy	NNP
cord-310192-8x37nx4s	12	9	offers	offer	VBZ
cord-310192-8x37nx4s	12	10	a	a	DT
cord-310192-8x37nx4s	12	11	viable	viable	JJ
cord-310192-8x37nx4s	12	12	alternative	alternative	NN
cord-310192-8x37nx4s	12	13	to	to	IN
cord-310192-8x37nx4s	12	14	determining	determine	VBG
cord-310192-8x37nx4s	12	15	the	the	DT
cord-310192-8x37nx4s	12	16	structure	structure	NN
cord-310192-8x37nx4s	12	17	of	of	IN
cord-310192-8x37nx4s	12	18	large	large	JJ
cord-310192-8x37nx4s	12	19	RNA	RNA	NNP
cord-310192-8x37nx4s	12	20	molecules	molecule	NNS
cord-310192-8x37nx4s	12	21	that	that	WDT
cord-310192-8x37nx4s	12	22	do	do	VBP
cord-310192-8x37nx4s	12	23	not	not	RB
cord-310192-8x37nx4s	12	24	readily	readily	RB
cord-310192-8x37nx4s	12	25	crystallize	crystallize	VB
cord-310192-8x37nx4s	12	26	,	,	,
cord-310192-8x37nx4s	12	27	but	but	CC
cord-310192-8x37nx4s	12	28	is	be	VBZ
cord-310192-8x37nx4s	12	29	itself	-PRON-	PRP
cord-310192-8x37nx4s	12	30	hindered	hinder	VBN
cord-310192-8x37nx4s	12	31	by	by	IN
cord-310192-8x37nx4s	12	32	some	some	DT
cord-310192-8x37nx4s	12	33	technical	technical	JJ
cord-310192-8x37nx4s	12	34	limitations	limitation	NNS
cord-310192-8x37nx4s	12	35	.	.	.
cord-310192-8x37nx4s	13	1	Recently	recently	RB
cord-310192-8x37nx4s	13	2	,	,	,
cord-310192-8x37nx4s	13	3	a	a	DT
cord-310192-8x37nx4s	13	4	series	series	NN
cord-310192-8x37nx4s	13	5	of	of	IN
cord-310192-8x37nx4s	13	6	advancements	advancement	NNS
cord-310192-8x37nx4s	13	7	have	have	VBP
cord-310192-8x37nx4s	13	8	allowed	allow	VBN
cord-310192-8x37nx4s	13	9	the	the	DT
cord-310192-8x37nx4s	13	10	biomolecular	biomolecular	JJ
cord-310192-8x37nx4s	13	11	NMR	NMR	NNP
cord-310192-8x37nx4s	13	12	field	field	NN
cord-310192-8x37nx4s	13	13	to	to	TO
cord-310192-8x37nx4s	13	14	overcome	overcome	VB
cord-310192-8x37nx4s	13	15	,	,	,
cord-310192-8x37nx4s	13	16	at	at	IN
cord-310192-8x37nx4s	13	17	least	least	JJS
cord-310192-8x37nx4s	13	18	in	in	IN
cord-310192-8x37nx4s	13	19	part	part	NN
cord-310192-8x37nx4s	13	20	,	,	,
cord-310192-8x37nx4s	13	21	some	some	DT
cord-310192-8x37nx4s	13	22	of	of	IN
cord-310192-8x37nx4s	13	23	these	these	DT
cord-310192-8x37nx4s	13	24	limitations	limitation	NNS
cord-310192-8x37nx4s	13	25	.	.	.
cord-310192-8x37nx4s	14	1	These	these	DT
cord-310192-8x37nx4s	14	2	advances	advance	NNS
cord-310192-8x37nx4s	14	3	include	include	VBP
cord-310192-8x37nx4s	14	4	improvements	improvement	NNS
cord-310192-8x37nx4s	14	5	in	in	IN
cord-310192-8x37nx4s	14	6	sample	sample	NN
cord-310192-8x37nx4s	14	7	preparation	preparation	NN
cord-310192-8x37nx4s	14	8	strategies	strategy	NNS
cord-310192-8x37nx4s	14	9	as	as	RB
cord-310192-8x37nx4s	14	10	well	well	RB
cord-310192-8x37nx4s	14	11	as	as	IN
cord-310192-8x37nx4s	14	12	methodological	methodological	JJ
cord-310192-8x37nx4s	14	13	improvements	improvement	NNS
cord-310192-8x37nx4s	14	14	.	.	.
cord-310192-8x37nx4s	15	1	Together	together	RB
cord-310192-8x37nx4s	15	2	,	,	,
cord-310192-8x37nx4s	15	3	these	these	DT
cord-310192-8x37nx4s	15	4	innovations	innovation	NNS
cord-310192-8x37nx4s	15	5	pave	pave	VBP
cord-310192-8x37nx4s	15	6	the	the	DT
cord-310192-8x37nx4s	15	7	way	way	NN
cord-310192-8x37nx4s	15	8	for	for	IN
cord-310192-8x37nx4s	15	9	the	the	DT
cord-310192-8x37nx4s	15	10	study	study	NN
cord-310192-8x37nx4s	15	11	of	of	IN
cord-310192-8x37nx4s	15	12	ever	ever	RB
cord-310192-8x37nx4s	15	13	larger	large	JJR
cord-310192-8x37nx4s	15	14	RNA	RNA	NNP
cord-310192-8x37nx4s	15	15	molecules	molecule	NNS
cord-310192-8x37nx4s	15	16	that	that	WDT
cord-310192-8x37nx4s	15	17	have	have	VBP
cord-310192-8x37nx4s	15	18	important	important	JJ
cord-310192-8x37nx4s	15	19	biological	biological	JJ
cord-310192-8x37nx4s	15	20	function	function	NN
cord-310192-8x37nx4s	15	21	.	.	.
cord-310192-8x37nx4s	16	1	RNA	RNA	NNP
cord-310192-8x37nx4s	16	2	Structure	Structure	NNP
cord-310192-8x37nx4s	16	3	and	and	CC
cord-310192-8x37nx4s	16	4	Dynamics	Dynamics	NNP
cord-310192-8x37nx4s	16	5	>	>	XX
cord-310192-8x37nx4s	17	1	RNA	RNA	NNP
cord-310192-8x37nx4s	17	2	Structure	Structure	NNP
cord-310192-8x37nx4s	17	3	,	,	,
cord-310192-8x37nx4s	17	4	Dynamics	Dynamics	NNP
cord-310192-8x37nx4s	17	5	,	,	,
cord-310192-8x37nx4s	17	6	and	and	CC
cord-310192-8x37nx4s	17	7	Chemistry	Chemistry	NNP
cord-310192-8x37nx4s	17	8	.	.	.
cord-310192-8x37nx4s	18	1	Regulatory	regulatory	JJ
cord-310192-8x37nx4s	18	2	RNAs	rna	NNS
cord-310192-8x37nx4s	18	3	/	/	SYM
cord-310192-8x37nx4s	18	4	RNAi	RNAi	NNS
cord-310192-8x37nx4s	18	5	/	/	SYM
cord-310192-8x37nx4s	18	6	Riboswitches	Riboswitches	NNP
cord-310192-8x37nx4s	19	1	>	>	XX
cord-310192-8x37nx4s	20	1	Regulatory	regulatory	JJ
cord-310192-8x37nx4s	20	2	RNAs	rna	NNS
cord-310192-8x37nx4s	20	3	.	.	.
cord-310192-8x37nx4s	21	1	RNA	RNA	NNP
cord-310192-8x37nx4s	21	2	Structure	Structure	NNP
cord-310192-8x37nx4s	21	3	and	and	CC
cord-310192-8x37nx4s	21	4	Dynamics	Dynamics	NNP
cord-310192-8x37nx4s	22	1	>	>	XX
cord-310192-8x37nx4s	23	1	Influence	influence	NN
cord-310192-8x37nx4s	23	2	of	of	IN
cord-310192-8x37nx4s	23	3	RNA	RNA	NNP
cord-310192-8x37nx4s	23	4	Structure	Structure	NNP
cord-310192-8x37nx4s	23	5	in	in	IN
cord-310192-8x37nx4s	23	6	Biological	Biological	NNP
cord-310192-8x37nx4s	23	7	Systems	Systems	NNPS
cord-310192-8x37nx4s	23	8	.	.	.
cord-310192-8x37nx4s	24	1	functional	functional	JJ
cord-310192-8x37nx4s	24	2	long	long	JJ
cord-310192-8x37nx4s	24	3	ncRNAs	ncRNAs	NNP
cord-310192-8x37nx4s	24	4	has	have	VBZ
cord-310192-8x37nx4s	24	5	expanded	expand	VBN
cord-310192-8x37nx4s	24	6	our	-PRON-	PRP$
cord-310192-8x37nx4s	24	7	understanding	understanding	NN
cord-310192-8x37nx4s	24	8	of	of	IN
cord-310192-8x37nx4s	24	9	the	the	DT
cord-310192-8x37nx4s	24	10	roles	role	NNS
cord-310192-8x37nx4s	24	11	that	that	WDT
cord-310192-8x37nx4s	24	12	RNA	RNA	NNP
cord-310192-8x37nx4s	24	13	can	can	MD
cord-310192-8x37nx4s	24	14	play	play	VB
cord-310192-8x37nx4s	24	15	in	in	IN
cord-310192-8x37nx4s	24	16	the	the	DT
cord-310192-8x37nx4s	24	17	cell	cell	NN
cord-310192-8x37nx4s	24	18	.	.	.
cord-310192-8x37nx4s	25	1	Though	though	IN
cord-310192-8x37nx4s	25	2	several	several	JJ
cord-310192-8x37nx4s	25	3	classes	class	NNS
cord-310192-8x37nx4s	25	4	of	of	IN
cord-310192-8x37nx4s	25	5	ncRNAs	ncrna	NNS
cord-310192-8x37nx4s	25	6	are	be	VBP
cord-310192-8x37nx4s	25	7	active	active	JJ
cord-310192-8x37nx4s	25	8	players	player	NNS
cord-310192-8x37nx4s	25	9	in	in	IN
cord-310192-8x37nx4s	25	10	translation	translation	NN
cord-310192-8x37nx4s	25	11	-	-	HYPH
cord-310192-8x37nx4s	25	12	ribosomal	ribosomal	JJ
cord-310192-8x37nx4s	25	13	RNAs	rna	NNS
cord-310192-8x37nx4s	25	14	make	make	VBP
cord-310192-8x37nx4s	25	15	up	up	RP
cord-310192-8x37nx4s	25	16	the	the	DT
cord-310192-8x37nx4s	25	17	bulk	bulk	NN
cord-310192-8x37nx4s	25	18	of	of	IN
cord-310192-8x37nx4s	25	19	the	the	DT
cord-310192-8x37nx4s	25	20	translation	translation	NN
cord-310192-8x37nx4s	25	21	machinery	machinery	NN
cord-310192-8x37nx4s	25	22	while	while	IN
cord-310192-8x37nx4s	25	23	transfer	transfer	NN
cord-310192-8x37nx4s	25	24	RNAs	rna	NNS
cord-310192-8x37nx4s	25	25	shuttle	shuttle	NN
cord-310192-8x37nx4s	25	26	amino	amino	NN
cord-310192-8x37nx4s	25	27	acids	acid	NNS
cord-310192-8x37nx4s	25	28	into	into	IN
cord-310192-8x37nx4s	25	29	the	the	DT
cord-310192-8x37nx4s	25	30	ribosome	ribosome	NN
cord-310192-8x37nx4s	25	31	for	for	IN
cord-310192-8x37nx4s	25	32	incorporation	incorporation	NN
cord-310192-8x37nx4s	25	33	into	into	IN
cord-310192-8x37nx4s	25	34	the	the	DT
cord-310192-8x37nx4s	25	35	growing	grow	VBG
cord-310192-8x37nx4s	25	36	polypeptide	polypeptide	NN
cord-310192-8x37nx4s	25	37	chain	chain	NN
cord-310192-8x37nx4s	25	38	,	,	,
cord-310192-8x37nx4s	25	39	there	there	EX
cord-310192-8x37nx4s	25	40	is	be	VBZ
cord-310192-8x37nx4s	25	41	a	a	DT
cord-310192-8x37nx4s	25	42	growing	grow	VBG
cord-310192-8x37nx4s	25	43	appreciation	appreciation	NN
cord-310192-8x37nx4s	25	44	of	of	IN
cord-310192-8x37nx4s	25	45	the	the	DT
cord-310192-8x37nx4s	25	46	functional	functional	JJ
cord-310192-8x37nx4s	25	47	importance	importance	NN
cord-310192-8x37nx4s	25	48	of	of	IN
cord-310192-8x37nx4s	25	49	other	other	JJ
cord-310192-8x37nx4s	25	50	ncRNA	ncrna	NN
cord-310192-8x37nx4s	25	51	classes	class	NNS
cord-310192-8x37nx4s	25	52	as	as	RB
cord-310192-8x37nx4s	25	53	well	well	RB
cord-310192-8x37nx4s	25	54	as	as	IN
cord-310192-8x37nx4s	25	55	noncoding	noncoding	JJ
cord-310192-8x37nx4s	25	56	regions	region	NNS
cord-310192-8x37nx4s	25	57	of	of	IN
cord-310192-8x37nx4s	25	58	mRNAs	mrnas	CD
cord-310192-8x37nx4s	25	59	.	.	.
cord-310192-8x37nx4s	26	1	These	these	DT
cord-310192-8x37nx4s	26	2	elements	element	NNS
cord-310192-8x37nx4s	26	3	have	have	VBP
cord-310192-8x37nx4s	26	4	been	be	VBN
cord-310192-8x37nx4s	26	5	shown	show	VBN
cord-310192-8x37nx4s	26	6	to	to	TO
cord-310192-8x37nx4s	26	7	be	be	VB
cord-310192-8x37nx4s	26	8	key	key	JJ
cord-310192-8x37nx4s	26	9	players	player	NNS
cord-310192-8x37nx4s	26	10	in	in	IN
cord-310192-8x37nx4s	26	11	the	the	DT
cord-310192-8x37nx4s	26	12	regulation	regulation	NN
cord-310192-8x37nx4s	26	13	of	of	IN
cord-310192-8x37nx4s	26	14	gene	gene	NN
cord-310192-8x37nx4s	26	15	transcription	transcription	NN
cord-310192-8x37nx4s	26	16	and	and	CC
cord-310192-8x37nx4s	26	17	translation	translation	NN
cord-310192-8x37nx4s	26	18	,	,	,
cord-310192-8x37nx4s	26	19	epigenetic	epigenetic	JJ
cord-310192-8x37nx4s	26	20	control	control	NN
cord-310192-8x37nx4s	26	21	,	,	,
cord-310192-8x37nx4s	26	22	and	and	CC
cord-310192-8x37nx4s	26	23	RNA	RNA	NNP
cord-310192-8x37nx4s	26	24	turnover	turnover	NN
cord-310192-8x37nx4s	26	25	(	(	-LRB-
cord-310192-8x37nx4s	26	26	Bonasio	Bonasio	NNP
cord-310192-8x37nx4s	26	27	&	&	CC
cord-310192-8x37nx4s	26	28	Shiekhattar	Shiekhattar	NNP
cord-310192-8x37nx4s	26	29	,	,	,
cord-310192-8x37nx4s	26	30	2014	2014	CD
cord-310192-8x37nx4s	26	31	;	;	.
cord-310192-8x37nx4s	27	1	Guil	Guil	NNP
cord-310192-8x37nx4s	27	2	&	&	CC
cord-310192-8x37nx4s	27	3	Esteller	Esteller	NNP
cord-310192-8x37nx4s	27	4	,	,	,
cord-310192-8x37nx4s	27	5	2015	2015	CD
cord-310192-8x37nx4s	27	6	;	;	:
cord-310192-8x37nx4s	27	7	J.	J.	NNP
cord-310192-8x37nx4s	27	8	T.	T.	NNP
cord-310192-8x37nx4s	27	9	Lee	Lee	NNP
cord-310192-8x37nx4s	27	10	,	,	,
cord-310192-8x37nx4s	27	11	2012	2012	CD
cord-310192-8x37nx4s	27	12	)	)	-RRB-
cord-310192-8x37nx4s	27	13	.	.	.
cord-310192-8x37nx4s	28	1	Numerous	numerous	JJ
cord-310192-8x37nx4s	28	2	studies	study	NNS
cord-310192-8x37nx4s	28	3	have	have	VBP
cord-310192-8x37nx4s	28	4	highlighted	highlight	VBN
cord-310192-8x37nx4s	28	5	how	how	WRB
cord-310192-8x37nx4s	28	6	complex	complex	JJ
cord-310192-8x37nx4s	28	7	structural	structural	JJ
cord-310192-8x37nx4s	28	8	folds	fold	NNS
cord-310192-8x37nx4s	28	9	in	in	IN
cord-310192-8x37nx4s	28	10	RNA	RNA	NNP
cord-310192-8x37nx4s	28	11	molecules	molecule	NNS
cord-310192-8x37nx4s	28	12	confer	confer	VBP
cord-310192-8x37nx4s	28	13	specific	specific	JJ
cord-310192-8x37nx4s	28	14	functions	function	NNS
cord-310192-8x37nx4s	28	15	including	include	VBG
cord-310192-8x37nx4s	28	16	riboswitches	riboswitche	NNS
cord-310192-8x37nx4s	28	17	(	(	-LRB-
cord-310192-8x37nx4s	28	18	Knappenberger	Knappenberger	NNP
cord-310192-8x37nx4s	28	19	,	,	,
cord-310192-8x37nx4s	28	20	Reiss	Reiss	NNP
cord-310192-8x37nx4s	28	21	,	,	,
cord-310192-8x37nx4s	28	22	&	&	CC
cord-310192-8x37nx4s	28	23	Strobel	Strobel	NNP
cord-310192-8x37nx4s	28	24	,	,	,
cord-310192-8x37nx4s	28	25	2018	2018	CD
cord-310192-8x37nx4s	28	26	;	;	:
cord-310192-8x37nx4s	28	27	Liberman	Liberman	NNP
cord-310192-8x37nx4s	28	28	et	et	NNP
cord-310192-8x37nx4s	28	29	al	al	NNP
cord-310192-8x37nx4s	28	30	.	.	NNP
cord-310192-8x37nx4s	28	31	,	,	,
cord-310192-8x37nx4s	28	32	2015	2015	CD
cord-310192-8x37nx4s	28	33	;	;	:
cord-310192-8x37nx4s	28	34	Peselis	Peselis	NNP
cord-310192-8x37nx4s	28	35	&	&	CC
cord-310192-8x37nx4s	28	36	Serganov	Serganov	NNP
cord-310192-8x37nx4s	28	37	,	,	,
cord-310192-8x37nx4s	28	38	2018	2018	CD
cord-310192-8x37nx4s	28	39	;	;	:
cord-310192-8x37nx4s	29	1	Vicens	Vicens	NNP
cord-310192-8x37nx4s	29	2	et	et	NNP
cord-310192-8x37nx4s	29	3	al	al	NNP
cord-310192-8x37nx4s	29	4	.	.	NNP
cord-310192-8x37nx4s	29	5	,	,	,
cord-310192-8x37nx4s	29	6	2018	2018	CD
cord-310192-8x37nx4s	29	7	;	;	:
cord-310192-8x37nx4s	29	8	B.	B.	NNP
cord-310192-8x37nx4s	29	9	Zhao	Zhao	NNP
cord-310192-8x37nx4s	29	10	,	,	,
cord-310192-8x37nx4s	29	11	Guffy	Guffy	NNP
cord-310192-8x37nx4s	29	12	,	,	,
cord-310192-8x37nx4s	29	13	Williams	Williams	NNP
cord-310192-8x37nx4s	29	14	,	,	,
cord-310192-8x37nx4s	29	15	&	&	CC
cord-310192-8x37nx4s	29	16	Zhang	Zhang	NNP
cord-310192-8x37nx4s	29	17	,	,	,
cord-310192-8x37nx4s	29	18	2017	2017	CD
cord-310192-8x37nx4s	29	19	;	;	:
cord-310192-8x37nx4s	29	20	also	also	RB
cord-310192-8x37nx4s	29	21	reviewed	review	VBN
cord-310192-8x37nx4s	29	22	by	by	IN
cord-310192-8x37nx4s	29	23	Jones	Jones	NNP
cord-310192-8x37nx4s	29	24	&	&	CC
cord-310192-8x37nx4s	29	25	Ferre	Ferre	NNP
cord-310192-8x37nx4s	29	26	-	-	HYPH
cord-310192-8x37nx4s	29	27	D'Amare	D'Amare	NNP
cord-310192-8x37nx4s	29	28	,	,	,
cord-310192-8x37nx4s	29	29	2017	2017	CD
cord-310192-8x37nx4s	29	30	;	;	:
cord-310192-8x37nx4s	29	31	Roth	Roth	NNP
cord-310192-8x37nx4s	29	32	&	&	CC
cord-310192-8x37nx4s	29	33	Breaker	Breaker	NNP
cord-310192-8x37nx4s	29	34	,	,	,
cord-310192-8x37nx4s	29	35	2009	2009	CD
cord-310192-8x37nx4s	29	36	)	)	-RRB-
cord-310192-8x37nx4s	29	37	,	,	,
cord-310192-8x37nx4s	29	38	ribozymes	ribozyme	NNS
cord-310192-8x37nx4s	29	39	(	(	-LRB-
cord-310192-8x37nx4s	29	40	Chan	Chan	NNP
cord-310192-8x37nx4s	29	41	et	et	NNP
cord-310192-8x37nx4s	29	42	al	al	NNP
cord-310192-8x37nx4s	29	43	.	.	NNP
cord-310192-8x37nx4s	29	44	,	,	,
cord-310192-8x37nx4s	29	45	2018	2018	CD
cord-310192-8x37nx4s	29	46	;	;	:
cord-310192-8x37nx4s	29	47	Costa	Costa	NNP
cord-310192-8x37nx4s	29	48	,	,	,
cord-310192-8x37nx4s	29	49	Walbott	Walbott	NNP
cord-310192-8x37nx4s	29	50	,	,	,
cord-310192-8x37nx4s	29	51	Monachello	Monachello	NNP
cord-310192-8x37nx4s	29	52	,	,	,
cord-310192-8x37nx4s	29	53	Westhof	Westhof	NNP
cord-310192-8x37nx4s	29	54	,	,	,
cord-310192-8x37nx4s	29	55	&	&	CC
cord-310192-8x37nx4s	29	56	Michel	Michel	NNP
cord-310192-8x37nx4s	29	57	,	,	,
cord-310192-8x37nx4s	29	58	2016	2016	CD
cord-310192-8x37nx4s	29	59	;	;	:
cord-310192-8x37nx4s	29	60	Meyer	Meyer	NNP
cord-310192-8x37nx4s	29	61	et	et	NNP
cord-310192-8x37nx4s	29	62	al	al	NNP
cord-310192-8x37nx4s	29	63	.	.	NNP
cord-310192-8x37nx4s	29	64	,	,	,
cord-310192-8x37nx4s	29	65	2014	2014	CD
cord-310192-8x37nx4s	29	66	;	;	:
cord-310192-8x37nx4s	29	67	L.	L.	NNP
cord-310192-8x37nx4s	29	68	A.	A.	NNP
cord-310192-8x37nx4s	29	69	Nguyen	Nguyen	NNP
cord-310192-8x37nx4s	29	70	,	,	,
cord-310192-8x37nx4s	29	71	Wang	Wang	NNP
cord-310192-8x37nx4s	29	72	,	,	,
cord-310192-8x37nx4s	29	73	&	&	CC
cord-310192-8x37nx4s	29	74	Steitz	Steitz	NNP
cord-310192-8x37nx4s	29	75	,	,	,
cord-310192-8x37nx4s	29	76	2017	2017	CD
cord-310192-8x37nx4s	29	77	;	;	:
cord-310192-8x37nx4s	29	78	Qu	Qu	NNP
cord-310192-8x37nx4s	29	79	et	et	NNP
cord-310192-8x37nx4s	29	80	al	al	NNP
cord-310192-8x37nx4s	29	81	.	.	.
cord-310192-8x37nx4s	30	1	,	,	,
cord-310192-8x37nx4s	30	2	2016	2016	CD
cord-310192-8x37nx4s	30	3	;	;	:
cord-310192-8x37nx4s	30	4	Suslov	Suslov	NNP
cord-310192-8x37nx4s	30	5	et	et	FW
cord-310192-8x37nx4s	30	6	al	al	NNP
cord-310192-8x37nx4s	30	7	.	.	NNP
cord-310192-8x37nx4s	30	8	,	,	,
cord-310192-8x37nx4s	30	9	2015	2015	CD
cord-310192-8x37nx4s	30	10	;	;	:
cord-310192-8x37nx4s	30	11	C.	C.	NNP
cord-310192-8x37nx4s	30	12	Zhao	Zhao	NNP
cord-310192-8x37nx4s	30	13	,	,	,
cord-310192-8x37nx4s	30	14	Rajashankar	Rajashankar	NNP
cord-310192-8x37nx4s	30	15	,	,	,
cord-310192-8x37nx4s	30	16	Marcia	Marcia	NNP
cord-310192-8x37nx4s	30	17	,	,	,
cord-310192-8x37nx4s	30	18	&	&	CC
cord-310192-8x37nx4s	30	19	Pyle	Pyle	NNP
cord-310192-8x37nx4s	30	20	,	,	,
cord-310192-8x37nx4s	30	21	2015	2015	CD
cord-310192-8x37nx4s	30	22	;	;	:
cord-310192-8x37nx4s	30	23	also	also	RB
cord-310192-8x37nx4s	30	24	reviewed	review	VBN
cord-310192-8x37nx4s	30	25	by	by	IN
cord-310192-8x37nx4s	30	26	Pyle	Pyle	NNP
cord-310192-8x37nx4s	30	27	,	,	,
cord-310192-8x37nx4s	30	28	2016	2016	CD
cord-310192-8x37nx4s	30	29	;	;	:
cord-310192-8x37nx4s	30	30	Ren	Ren	NNP
cord-310192-8x37nx4s	30	31	,	,	,
cord-310192-8x37nx4s	30	32	Micura	Micura	NNP
cord-310192-8x37nx4s	30	33	,	,	,
cord-310192-8x37nx4s	30	34	&	&	CC
cord-310192-8x37nx4s	30	35	Patel	Patel	NNP
cord-310192-8x37nx4s	30	36	,	,	,
cord-310192-8x37nx4s	30	37	2017	2017	CD
cord-310192-8x37nx4s	30	38	)	)	-RRB-
cord-310192-8x37nx4s	30	39	,	,	,
cord-310192-8x37nx4s	30	40	and	and	CC
cord-310192-8x37nx4s	30	41	viral	viral	JJ
cord-310192-8x37nx4s	30	42	elements	element	NNS
cord-310192-8x37nx4s	30	43	(	(	-LRB-
cord-310192-8x37nx4s	30	44	Akiyama	Akiyama	NNP
cord-310192-8x37nx4s	30	45	et	et	FW
cord-310192-8x37nx4s	30	46	al	al	NNP
cord-310192-8x37nx4s	30	47	.	.	NNP
cord-310192-8x37nx4s	30	48	,	,	,
cord-310192-8x37nx4s	30	49	2016	2016	CD
cord-310192-8x37nx4s	30	50	;	;	:
cord-310192-8x37nx4s	30	51	Au	Au	NNP
cord-310192-8x37nx4s	30	52	et	et	FW
cord-310192-8x37nx4s	30	53	al	al	NNP
cord-310192-8x37nx4s	30	54	.	.	NNP
cord-310192-8x37nx4s	30	55	,	,	,
cord-310192-8x37nx4s	30	56	2015	2015	CD
cord-310192-8x37nx4s	30	57	;	;	:
cord-310192-8x37nx4s	30	58	Imai	Imai	NNP
cord-310192-8x37nx4s	30	59	,	,	,
cord-310192-8x37nx4s	30	60	Kumar	Kumar	NNP
cord-310192-8x37nx4s	30	61	,	,	,
cord-310192-8x37nx4s	30	62	Hellen	Hellen	NNP
cord-310192-8x37nx4s	30	63	,	,	,
cord-310192-8x37nx4s	30	64	D'Souza	D'Souza	NNP
cord-310192-8x37nx4s	30	65	,	,	,
cord-310192-8x37nx4s	30	66	&	&	CC
cord-310192-8x37nx4s	30	67	Wagner	Wagner	NNP
cord-310192-8x37nx4s	30	68	,	,	,
cord-310192-8x37nx4s	30	69	2016	2016	CD
cord-310192-8x37nx4s	30	70	;	;	:
cord-310192-8x37nx4s	30	71	Keane	Keane	NNP
cord-310192-8x37nx4s	30	72	et	et	NNP
cord-310192-8x37nx4s	30	73	al	al	NNP
cord-310192-8x37nx4s	30	74	.	.	NNP
cord-310192-8x37nx4s	30	75	,	,	,
cord-310192-8x37nx4s	30	76	2015	2015	CD
cord-310192-8x37nx4s	30	77	)	)	-RRB-
cord-310192-8x37nx4s	30	78	.	.	.
cord-310192-8x37nx4s	31	1	Additionally	additionally	RB
cord-310192-8x37nx4s	31	2	,	,	,
cord-310192-8x37nx4s	31	3	recent	recent	JJ
cord-310192-8x37nx4s	31	4	studies	study	NNS
cord-310192-8x37nx4s	31	5	have	have	VBP
cord-310192-8x37nx4s	31	6	identified	identify	VBN
cord-310192-8x37nx4s	31	7	highly	highly	RB
cord-310192-8x37nx4s	31	8	structured	structure	VBN
cord-310192-8x37nx4s	31	9	ncRNAs	ncRNAs	NNP
cord-310192-8x37nx4s	31	10	as	as	IN
cord-310192-8x37nx4s	31	11	important	important	JJ
cord-310192-8x37nx4s	31	12	regulators	regulator	NNS
cord-310192-8x37nx4s	31	13	in	in	IN
cord-310192-8x37nx4s	31	14	various	various	JJ
cord-310192-8x37nx4s	31	15	cellular	cellular	JJ
cord-310192-8x37nx4s	31	16	processes	process	NNS
cord-310192-8x37nx4s	31	17	and	and	CC
cord-310192-8x37nx4s	31	18	linked	link	VBN
cord-310192-8x37nx4s	31	19	misregulation	misregulation	NN
cord-310192-8x37nx4s	31	20	of	of	IN
cord-310192-8x37nx4s	31	21	ncRNAs	ncrna	NNS
cord-310192-8x37nx4s	31	22	to	to	IN
cord-310192-8x37nx4s	31	23	important	important	JJ
cord-310192-8x37nx4s	31	24	human	human	JJ
cord-310192-8x37nx4s	31	25	diseases	disease	NNS
cord-310192-8x37nx4s	31	26	(	(	-LRB-
cord-310192-8x37nx4s	31	27	Esteller	Esteller	NNP
cord-310192-8x37nx4s	31	28	,	,	,
cord-310192-8x37nx4s	31	29	2011	2011	CD
cord-310192-8x37nx4s	31	30	)	)	-RRB-
cord-310192-8x37nx4s	31	31	.	.	.
cord-310192-8x37nx4s	32	1	For	for	IN
cord-310192-8x37nx4s	32	2	these	these	DT
cord-310192-8x37nx4s	32	3	reasons	reason	NNS
cord-310192-8x37nx4s	32	4	,	,	,
cord-310192-8x37nx4s	32	5	ncRNAs	ncrna	NNS
cord-310192-8x37nx4s	32	6	are	be	VBP
cord-310192-8x37nx4s	32	7	attracting	attract	VBG
cord-310192-8x37nx4s	32	8	increased	increase	VBN
cord-310192-8x37nx4s	32	9	attention	attention	NN
cord-310192-8x37nx4s	32	10	in	in	IN
cord-310192-8x37nx4s	32	11	both	both	DT
cord-310192-8x37nx4s	32	12	drug	drug	NN
cord-310192-8x37nx4s	32	13	design	design	NN
cord-310192-8x37nx4s	32	14	and	and	CC
cord-310192-8x37nx4s	32	15	intermolecular	intermolecular	JJ
cord-310192-8x37nx4s	32	16	recognition	recognition	NN
cord-310192-8x37nx4s	33	1	(	(	-LRB-
cord-310192-8x37nx4s	33	2	Warner	Warner	NNP
cord-310192-8x37nx4s	33	3	,	,	,
cord-310192-8x37nx4s	33	4	Hajdin	Hajdin	NNP
cord-310192-8x37nx4s	33	5	,	,	,
cord-310192-8x37nx4s	33	6	&	&	CC
cord-310192-8x37nx4s	33	7	Weeks	Weeks	NNP
cord-310192-8x37nx4s	33	8	,	,	,
cord-310192-8x37nx4s	33	9	2018	2018	CD
cord-310192-8x37nx4s	33	10	)	)	-RRB-
cord-310192-8x37nx4s	33	11	.	.	.
cord-310192-8x37nx4s	34	1	Structural	structural	JJ
cord-310192-8x37nx4s	34	2	study	study	NN
cord-310192-8x37nx4s	34	3	of	of	IN
cord-310192-8x37nx4s	34	4	these	these	DT
cord-310192-8x37nx4s	34	5	important	important	JJ
cord-310192-8x37nx4s	34	6	RNAs	rna	NNS
cord-310192-8x37nx4s	34	7	is	be	VBZ
cord-310192-8x37nx4s	34	8	becoming	become	VBG
cord-310192-8x37nx4s	34	9	increasingly	increasingly	RB
cord-310192-8x37nx4s	34	10	necessary	necessary	JJ
cord-310192-8x37nx4s	34	11	to	to	TO
cord-310192-8x37nx4s	34	12	understand	understand	VB
cord-310192-8x37nx4s	34	13	how	how	WRB
cord-310192-8x37nx4s	34	14	highly	highly	RB
cord-310192-8x37nx4s	34	15	structured	structured	JJ
cord-310192-8x37nx4s	34	16	RNAs	rna	NNS
cord-310192-8x37nx4s	34	17	function	function	VBP
cord-310192-8x37nx4s	34	18	and	and	CC
cord-310192-8x37nx4s	34	19	interact	interact	VB
cord-310192-8x37nx4s	34	20	with	with	IN
cord-310192-8x37nx4s	34	21	other	other	JJ
cord-310192-8x37nx4s	34	22	RNAs	rna	NNS
cord-310192-8x37nx4s	34	23	,	,	,
cord-310192-8x37nx4s	34	24	proteins	protein	NNS
cord-310192-8x37nx4s	34	25	,	,	,
cord-310192-8x37nx4s	34	26	and	and	CC
cord-310192-8x37nx4s	34	27	small	small	JJ
cord-310192-8x37nx4s	34	28	molecule	molecule	NN
cord-310192-8x37nx4s	34	29	ligands	ligand	NNS
cord-310192-8x37nx4s	34	30	.	.	.
cord-310192-8x37nx4s	35	1	Elucidation	elucidation	NN
cord-310192-8x37nx4s	35	2	of	of	IN
cord-310192-8x37nx4s	35	3	three	three	CD
cord-310192-8x37nx4s	35	4	-	-	HYPH
cord-310192-8x37nx4s	35	5	dimensional	dimensional	JJ
cord-310192-8x37nx4s	35	6	structures	structure	NNS
cord-310192-8x37nx4s	35	7	and	and	CC
cord-310192-8x37nx4s	35	8	conformational	conformational	JJ
cord-310192-8x37nx4s	35	9	landscapes	landscape	NNS
cord-310192-8x37nx4s	35	10	provides	provide	VBZ
cord-310192-8x37nx4s	35	11	detailed	detailed	JJ
cord-310192-8x37nx4s	35	12	information	information	NN
cord-310192-8x37nx4s	35	13	of	of	IN
cord-310192-8x37nx4s	35	14	their	-PRON-	PRP$
cord-310192-8x37nx4s	35	15	regulatory	regulatory	JJ
cord-310192-8x37nx4s	35	16	mechanisms	mechanism	NNS
cord-310192-8x37nx4s	35	17	.	.	.
cord-310192-8x37nx4s	36	1	In	in	IN
cord-310192-8x37nx4s	36	2	this	this	DT
cord-310192-8x37nx4s	36	3	review	review	NN
cord-310192-8x37nx4s	36	4	,	,	,
cord-310192-8x37nx4s	36	5	we	-PRON-	PRP
cord-310192-8x37nx4s	36	6	will	will	MD
cord-310192-8x37nx4s	36	7	give	give	VB
cord-310192-8x37nx4s	36	8	a	a	DT
cord-310192-8x37nx4s	36	9	broad	broad	JJ
cord-310192-8x37nx4s	36	10	overview	overview	NN
cord-310192-8x37nx4s	36	11	of	of	IN
cord-310192-8x37nx4s	36	12	different	different	JJ
cord-310192-8x37nx4s	36	13	methods	method	NNS
cord-310192-8x37nx4s	36	14	for	for	IN
cord-310192-8x37nx4s	36	15	structure	structure	NN
cord-310192-8x37nx4s	36	16	determination	determination	NN
cord-310192-8x37nx4s	36	17	and	and	CC
cord-310192-8x37nx4s	36	18	discuss	discuss	VB
cord-310192-8x37nx4s	36	19	some	some	DT
cord-310192-8x37nx4s	36	20	recent	recent	JJ
cord-310192-8x37nx4s	36	21	advancements	advancement	NNS
cord-310192-8x37nx4s	36	22	in	in	IN
cord-310192-8x37nx4s	36	23	both	both	DT
cord-310192-8x37nx4s	36	24	sample	sample	NN
cord-310192-8x37nx4s	36	25	preparation	preparation	NN
cord-310192-8x37nx4s	36	26	and	and	CC
cord-310192-8x37nx4s	36	27	data	data	NN
cord-310192-8x37nx4s	36	28	acquisition	acquisition	NN
cord-310192-8x37nx4s	36	29	that	that	WDT
cord-310192-8x37nx4s	36	30	have	have	VBP
cord-310192-8x37nx4s	36	31	advanced	advance	VBN
cord-310192-8x37nx4s	36	32	the	the	DT
cord-310192-8x37nx4s	36	33	study	study	NN
cord-310192-8x37nx4s	36	34	of	of	IN
cord-310192-8x37nx4s	36	35	large	large	JJ
cord-310192-8x37nx4s	36	36	RNAs	rna	NNS
cord-310192-8x37nx4s	36	37	by	by	IN
cord-310192-8x37nx4s	36	38	nuclear	nuclear	JJ
cord-310192-8x37nx4s	36	39	magnetic	magnetic	JJ
cord-310192-8x37nx4s	36	40	resonance	resonance	NN
cord-310192-8x37nx4s	36	41	(	(	-LRB-
cord-310192-8x37nx4s	36	42	NMR	NMR	NNP
cord-310192-8x37nx4s	36	43	)	)	-RRB-
cord-310192-8x37nx4s	36	44	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	36	45	.	.	.
cord-310192-8x37nx4s	37	1	First	first	RB
cord-310192-8x37nx4s	37	2	developed	develop	VBD
cord-310192-8x37nx4s	37	3	more	more	JJR
cord-310192-8x37nx4s	37	4	than	than	IN
cord-310192-8x37nx4s	37	5	30	30	CD
cord-310192-8x37nx4s	37	6	years	year	NNS
cord-310192-8x37nx4s	37	7	ago	ago	RB
cord-310192-8x37nx4s	37	8	,	,	,
cord-310192-8x37nx4s	37	9	chemical	chemical	NN
cord-310192-8x37nx4s	37	10	probing	probing	NN
cord-310192-8x37nx4s	37	11	of	of	IN
cord-310192-8x37nx4s	37	12	RNA	RNA	NNP
cord-310192-8x37nx4s	37	13	can	can	MD
cord-310192-8x37nx4s	37	14	be	be	VB
cord-310192-8x37nx4s	37	15	a	a	DT
cord-310192-8x37nx4s	37	16	useful	useful	JJ
cord-310192-8x37nx4s	37	17	tool	tool	NN
cord-310192-8x37nx4s	37	18	to	to	TO
cord-310192-8x37nx4s	37	19	rapidly	rapidly	RB
cord-310192-8x37nx4s	37	20	gain	gain	VB
cord-310192-8x37nx4s	37	21	nucleotide	nucleotide	JJ
cord-310192-8x37nx4s	37	22	-	-	HYPH
cord-310192-8x37nx4s	37	23	level	level	NN
cord-310192-8x37nx4s	37	24	structural	structural	JJ
cord-310192-8x37nx4s	37	25	information	information	NN
cord-310192-8x37nx4s	38	1	(	(	-LRB-
cord-310192-8x37nx4s	38	2	Ehresmann	Ehresmann	NNP
cord-310192-8x37nx4s	38	3	et	et	NNP
cord-310192-8x37nx4s	38	4	al	al	NNP
cord-310192-8x37nx4s	38	5	.	.	NNP
cord-310192-8x37nx4s	38	6	,	,	,
cord-310192-8x37nx4s	38	7	1987	1987	CD
cord-310192-8x37nx4s	38	8	;	;	:
cord-310192-8x37nx4s	38	9	Peattie	Peattie	NNP
cord-310192-8x37nx4s	38	10	&	&	CC
cord-310192-8x37nx4s	38	11	Gilbert	Gilbert	NNP
cord-310192-8x37nx4s	38	12	,	,	,
cord-310192-8x37nx4s	38	13	1980	1980	CD
cord-310192-8x37nx4s	38	14	;	;	.
cord-310192-8x37nx4s	39	1	Stern	Stern	NNP
cord-310192-8x37nx4s	39	2	,	,	,
cord-310192-8x37nx4s	39	3	Moazed	Moazed	NNP
cord-310192-8x37nx4s	39	4	,	,	,
cord-310192-8x37nx4s	39	5	&	&	CC
cord-310192-8x37nx4s	39	6	Noller	Noller	NNP
cord-310192-8x37nx4s	39	7	,	,	,
cord-310192-8x37nx4s	39	8	1988	1988	CD
cord-310192-8x37nx4s	39	9	)	)	-RRB-
cord-310192-8x37nx4s	39	10	.	.	.
cord-310192-8x37nx4s	40	1	Base	base	NN
cord-310192-8x37nx4s	40	2	-	-	HYPH
cord-310192-8x37nx4s	40	3	pairing	pairing	NN
cord-310192-8x37nx4s	40	4	,	,	,
cord-310192-8x37nx4s	40	5	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	40	6	bonding	bonding	NN
cord-310192-8x37nx4s	40	7	,	,	,
cord-310192-8x37nx4s	40	8	nucleotide	nucleotide	JJ
cord-310192-8x37nx4s	40	9	accessibility	accessibility	NN
cord-310192-8x37nx4s	40	10	and	and	CC
cord-310192-8x37nx4s	40	11	other	other	JJ
cord-310192-8x37nx4s	40	12	secondary	secondary	JJ
cord-310192-8x37nx4s	40	13	structure	structure	NN
cord-310192-8x37nx4s	40	14	-	-	HYPH
cord-310192-8x37nx4s	40	15	related	relate	VBN
cord-310192-8x37nx4s	40	16	characteristics	characteristic	NNS
cord-310192-8x37nx4s	40	17	,	,	,
cord-310192-8x37nx4s	40	18	can	can	MD
cord-310192-8x37nx4s	40	19	be	be	VB
cord-310192-8x37nx4s	40	20	obtained	obtain	VBN
cord-310192-8x37nx4s	40	21	by	by	IN
cord-310192-8x37nx4s	40	22	treating	treat	VBG
cord-310192-8x37nx4s	40	23	RNAs	rna	NNS
cord-310192-8x37nx4s	40	24	with	with	IN
cord-310192-8x37nx4s	40	25	specific	specific	JJ
cord-310192-8x37nx4s	40	26	chemical	chemical	NN
cord-310192-8x37nx4s	40	27	reagents	reagent	NNS
cord-310192-8x37nx4s	40	28	(	(	-LRB-
cord-310192-8x37nx4s	40	29	typically	typically	RB
cord-310192-8x37nx4s	40	30	dimethyl	dimethyl	NN
cord-310192-8x37nx4s	40	31	sulfate	sulfate	NN
cord-310192-8x37nx4s	40	32	[	[	-LRB-
cord-310192-8x37nx4s	40	33	DMS	dms	NN
cord-310192-8x37nx4s	40	34	]	]	-RRB-
cord-310192-8x37nx4s	41	1	and/or	and/or	CC
cord-310192-8x37nx4s	41	2	one	one	CD
cord-310192-8x37nx4s	41	3	or	or	CC
cord-310192-8x37nx4s	41	4	more	more	JJR
cord-310192-8x37nx4s	41	5	SHAPE	shape	NN
cord-310192-8x37nx4s	41	6	reagents	reagent	NNS
cord-310192-8x37nx4s	41	7	)	)	-RRB-
cord-310192-8x37nx4s	41	8	and	and	CC
cord-310192-8x37nx4s	41	9	probing	probe	VBG
cord-310192-8x37nx4s	41	10	for	for	IN
cord-310192-8x37nx4s	41	11	the	the	DT
cord-310192-8x37nx4s	41	12	sites	site	NNS
cord-310192-8x37nx4s	41	13	of	of	IN
cord-310192-8x37nx4s	41	14	modification	modification	NN
cord-310192-8x37nx4s	41	15	by	by	IN
cord-310192-8x37nx4s	41	16	sequencing	sequence	VBG
cord-310192-8x37nx4s	41	17	(	(	-LRB-
cord-310192-8x37nx4s	41	18	Cordero	Cordero	NNP
cord-310192-8x37nx4s	41	19	,	,	,
cord-310192-8x37nx4s	41	20	Kladwang	Kladwang	NNP
cord-310192-8x37nx4s	41	21	,	,	,
cord-310192-8x37nx4s	41	22	VanLang	VanLang	NNP
cord-310192-8x37nx4s	41	23	,	,	,
cord-310192-8x37nx4s	41	24	&	&	CC
cord-310192-8x37nx4s	41	25	Das	Das	NNP
cord-310192-8x37nx4s	41	26	,	,	,
cord-310192-8x37nx4s	41	27	2012	2012	CD
cord-310192-8x37nx4s	41	28	;	;	:
cord-310192-8x37nx4s	41	29	Merino	Merino	NNP
cord-310192-8x37nx4s	41	30	,	,	,
cord-310192-8x37nx4s	41	31	Wilkinson	Wilkinson	NNP
cord-310192-8x37nx4s	41	32	,	,	,
cord-310192-8x37nx4s	41	33	Coughlan	Coughlan	NNP
cord-310192-8x37nx4s	41	34	,	,	,
cord-310192-8x37nx4s	41	35	&	&	CC
cord-310192-8x37nx4s	41	36	Weeks	Weeks	NNP
cord-310192-8x37nx4s	41	37	,	,	,
cord-310192-8x37nx4s	41	38	2005	2005	CD
cord-310192-8x37nx4s	41	39	;	;	:
cord-310192-8x37nx4s	41	40	Tian	Tian	NNP
cord-310192-8x37nx4s	41	41	&	&	CC
cord-310192-8x37nx4s	41	42	Das	Das	NNP
cord-310192-8x37nx4s	41	43	,	,	,
cord-310192-8x37nx4s	41	44	2016	2016	CD
cord-310192-8x37nx4s	41	45	;	;	.
cord-310192-8x37nx4s	42	1	Weeks	week	NNS
cord-310192-8x37nx4s	42	2	,	,	,
cord-310192-8x37nx4s	42	3	2010	2010	CD
cord-310192-8x37nx4s	42	4	)	)	-RRB-
cord-310192-8x37nx4s	42	5	.	.	.
cord-310192-8x37nx4s	43	1	Reactivity	reactivity	NN
cord-310192-8x37nx4s	43	2	data	datum	NNS
cord-310192-8x37nx4s	43	3	derived	derive	VBN
cord-310192-8x37nx4s	43	4	from	from	IN
cord-310192-8x37nx4s	43	5	chemical	chemical	JJ
cord-310192-8x37nx4s	43	6	probing	probing	NN
cord-310192-8x37nx4s	43	7	studies	study	NNS
cord-310192-8x37nx4s	43	8	can	can	MD
cord-310192-8x37nx4s	43	9	be	be	VB
cord-310192-8x37nx4s	43	10	converted	convert	VBN
cord-310192-8x37nx4s	43	11	to	to	IN
cord-310192-8x37nx4s	43	12	pseudo	pseudo	JJ
cord-310192-8x37nx4s	43	13	free	free	JJ
cord-310192-8x37nx4s	43	14	energy	energy	NN
cord-310192-8x37nx4s	43	15	terms	term	NNS
cord-310192-8x37nx4s	43	16	and	and	CC
cord-310192-8x37nx4s	43	17	then	then	RB
cord-310192-8x37nx4s	43	18	incorporated	incorporate	VBD
cord-310192-8x37nx4s	43	19	into	into	IN
cord-310192-8x37nx4s	43	20	a	a	DT
cord-310192-8x37nx4s	43	21	secondary	secondary	JJ
cord-310192-8x37nx4s	43	22	structure	structure	NN
cord-310192-8x37nx4s	43	23	prediction	prediction	NN
cord-310192-8x37nx4s	43	24	algorithms	algorithm	NNS
cord-310192-8x37nx4s	43	25	to	to	TO
cord-310192-8x37nx4s	43	26	bolster	bolster	VB
cord-310192-8x37nx4s	43	27	the	the	DT
cord-310192-8x37nx4s	43	28	quality	quality	NN
cord-310192-8x37nx4s	43	29	of	of	IN
cord-310192-8x37nx4s	43	30	the	the	DT
cord-310192-8x37nx4s	43	31	resulting	result	VBG
cord-310192-8x37nx4s	43	32	structure	structure	NN
cord-310192-8x37nx4s	43	33	predictions	prediction	NNS
cord-310192-8x37nx4s	43	34	(	(	-LRB-
cord-310192-8x37nx4s	43	35	Cordero	Cordero	NNP
cord-310192-8x37nx4s	43	36	et	et	NNP
cord-310192-8x37nx4s	43	37	al	al	NNP
cord-310192-8x37nx4s	43	38	.	.	NNP
cord-310192-8x37nx4s	43	39	,	,	,
cord-310192-8x37nx4s	43	40	2012	2012	CD
cord-310192-8x37nx4s	43	41	;	;	:
cord-310192-8x37nx4s	43	42	Deigan	Deigan	NNP
cord-310192-8x37nx4s	43	43	,	,	,
cord-310192-8x37nx4s	43	44	Li	Li	NNP
cord-310192-8x37nx4s	43	45	,	,	,
cord-310192-8x37nx4s	43	46	Mathews	Mathews	NNP
cord-310192-8x37nx4s	43	47	,	,	,
cord-310192-8x37nx4s	43	48	&	&	CC
cord-310192-8x37nx4s	43	49	Weeks	Weeks	NNP
cord-310192-8x37nx4s	43	50	,	,	,
cord-310192-8x37nx4s	43	51	2009	2009	CD
cord-310192-8x37nx4s	43	52	;	;	:
cord-310192-8x37nx4s	43	53	Reuter	Reuter	NNP
cord-310192-8x37nx4s	43	54	&	&	CC
cord-310192-8x37nx4s	43	55	Mathews	Mathews	NNP
cord-310192-8x37nx4s	43	56	,	,	,
cord-310192-8x37nx4s	43	57	2010	2010	CD
cord-310192-8x37nx4s	43	58	)	)	-RRB-
cord-310192-8x37nx4s	43	59	.	.	.
cord-310192-8x37nx4s	44	1	Chemical	chemical	NN
cord-310192-8x37nx4s	44	2	probing	probing	NN
cord-310192-8x37nx4s	44	3	remains	remain	VBZ
cord-310192-8x37nx4s	44	4	the	the	DT
cord-310192-8x37nx4s	44	5	best	good	JJS
cord-310192-8x37nx4s	44	6	method	method	NN
cord-310192-8x37nx4s	44	7	for	for	IN
cord-310192-8x37nx4s	44	8	high	high	JJ
cord-310192-8x37nx4s	44	9	-	-	HYPH
cord-310192-8x37nx4s	44	10	throughput	throughput	NN
cord-310192-8x37nx4s	44	11	analysis	analysis	NN
cord-310192-8x37nx4s	44	12	of	of	IN
cord-310192-8x37nx4s	44	13	secondary	secondary	JJ
cord-310192-8x37nx4s	44	14	structure	structure	NN
cord-310192-8x37nx4s	44	15	within	within	IN
cord-310192-8x37nx4s	44	16	large	large	JJ
cord-310192-8x37nx4s	44	17	(	(	-LRB-
cord-310192-8x37nx4s	44	18	even	even	RB
cord-310192-8x37nx4s	44	19	genome	genome	NN
cord-310192-8x37nx4s	44	20	-	-	HYPH
cord-310192-8x37nx4s	44	21	wide	wide	RB
cord-310192-8x37nx4s	44	22	)	)	-RRB-
cord-310192-8x37nx4s	44	23	RNAs	rna	NNS
cord-310192-8x37nx4s	44	24	(	(	-LRB-
cord-310192-8x37nx4s	44	25	Bevilacqua	Bevilacqua	NNP
cord-310192-8x37nx4s	44	26	,	,	,
cord-310192-8x37nx4s	44	27	Ritchey	Ritchey	NNP
cord-310192-8x37nx4s	44	28	,	,	,
cord-310192-8x37nx4s	44	29	Su	Su	NNP
cord-310192-8x37nx4s	44	30	,	,	,
cord-310192-8x37nx4s	44	31	&	&	CC
cord-310192-8x37nx4s	44	32	Assmann	Assmann	NNP
cord-310192-8x37nx4s	44	33	,	,	,
cord-310192-8x37nx4s	44	34	2016	2016	CD
cord-310192-8x37nx4s	44	35	;	;	:
cord-310192-8x37nx4s	44	36	Watts	Watts	NNP
cord-310192-8x37nx4s	44	37	et	et	NNP
cord-310192-8x37nx4s	44	38	al	al	NNP
cord-310192-8x37nx4s	44	39	.	.	NNP
cord-310192-8x37nx4s	44	40	,	,	,
cord-310192-8x37nx4s	44	41	2009	2009	CD
cord-310192-8x37nx4s	44	42	;	;	:
cord-310192-8x37nx4s	44	43	Zubradt	Zubradt	NNP
cord-310192-8x37nx4s	44	44	et	et	FW
cord-310192-8x37nx4s	44	45	al	al	NNP
cord-310192-8x37nx4s	44	46	.	.	NNP
cord-310192-8x37nx4s	44	47	,	,	,
cord-310192-8x37nx4s	44	48	2017	2017	CD
cord-310192-8x37nx4s	44	49	)	)	-RRB-
cord-310192-8x37nx4s	44	50	.	.	.
cord-310192-8x37nx4s	45	1	However	however	RB
cord-310192-8x37nx4s	45	2	,	,	,
cord-310192-8x37nx4s	45	3	chemical	chemical	NN
cord-310192-8x37nx4s	45	4	probing	probing	NN
cord-310192-8x37nx4s	45	5	provides	provide	VBZ
cord-310192-8x37nx4s	45	6	limited	limited	JJ
cord-310192-8x37nx4s	45	7	insight	insight	NN
cord-310192-8x37nx4s	45	8	into	into	IN
cord-310192-8x37nx4s	45	9	RNA	RNA	NNP
cord-310192-8x37nx4s	45	10	tertiary	tertiary	JJ
cord-310192-8x37nx4s	45	11	structure	structure	NN
cord-310192-8x37nx4s	46	1	(	(	-LRB-
cord-310192-8x37nx4s	46	2	Homan	Homan	NNP
cord-310192-8x37nx4s	46	3	et	et	NNP
cord-310192-8x37nx4s	46	4	al	al	NNP
cord-310192-8x37nx4s	46	5	.	.	NNP
cord-310192-8x37nx4s	46	6	,	,	,
cord-310192-8x37nx4s	46	7	2014	2014	CD
cord-310192-8x37nx4s	46	8	)	)	-RRB-
cord-310192-8x37nx4s	46	9	and	and	CC
cord-310192-8x37nx4s	46	10	only	only	JJ
cord-310192-8x37nx4s	46	11	approximations	approximation	NNS
cord-310192-8x37nx4s	46	12	of	of	IN
cord-310192-8x37nx4s	46	13	fast	fast	JJ
cord-310192-8x37nx4s	46	14	time	time	NN
cord-310192-8x37nx4s	46	15	scale	scale	NN
cord-310192-8x37nx4s	46	16	dynamics	dynamic	NNS
cord-310192-8x37nx4s	46	17	of	of	IN
cord-310192-8x37nx4s	46	18	the	the	DT
cord-310192-8x37nx4s	46	19	molecule	molecule	NN
cord-310192-8x37nx4s	46	20	(	(	-LRB-
cord-310192-8x37nx4s	46	21	Gherghe	Gherghe	NNP
cord-310192-8x37nx4s	46	22	,	,	,
cord-310192-8x37nx4s	46	23	Shajani	Shajani	NNP
cord-310192-8x37nx4s	46	24	,	,	,
cord-310192-8x37nx4s	46	25	Wilkinson	Wilkinson	NNP
cord-310192-8x37nx4s	46	26	,	,	,
cord-310192-8x37nx4s	46	27	Varani	Varani	NNP
cord-310192-8x37nx4s	46	28	,	,	,
cord-310192-8x37nx4s	46	29	&	&	CC
cord-310192-8x37nx4s	46	30	Weeks	Weeks	NNP
cord-310192-8x37nx4s	46	31	,	,	,
cord-310192-8x37nx4s	46	32	2008	2008	CD
cord-310192-8x37nx4s	46	33	)	)	-RRB-
cord-310192-8x37nx4s	46	34	.	.	.
cord-310192-8x37nx4s	47	1	Biomolecular	biomolecular	JJ
cord-310192-8x37nx4s	47	2	structures	structure	NNS
cord-310192-8x37nx4s	47	3	at	at	IN
cord-310192-8x37nx4s	47	4	atomic	atomic	JJ
cord-310192-8x37nx4s	47	5	resolution	resolution	NN
cord-310192-8x37nx4s	47	6	provide	provide	VB
cord-310192-8x37nx4s	47	7	key	key	JJ
cord-310192-8x37nx4s	47	8	insights	insight	NNS
cord-310192-8x37nx4s	47	9	into	into	IN
cord-310192-8x37nx4s	47	10	the	the	DT
cord-310192-8x37nx4s	47	11	molecular	molecular	JJ
cord-310192-8x37nx4s	47	12	determinants	determinant	NNS
cord-310192-8x37nx4s	47	13	of	of	IN
cord-310192-8x37nx4s	47	14	interactions	interaction	NNS
cord-310192-8x37nx4s	47	15	,	,	,
cord-310192-8x37nx4s	47	16	the	the	DT
cord-310192-8x37nx4s	47	17	mechanisms	mechanism	NNS
cord-310192-8x37nx4s	47	18	of	of	IN
cord-310192-8x37nx4s	47	19	catalysis	catalysis	NN
cord-310192-8x37nx4s	47	20	,	,	,
cord-310192-8x37nx4s	47	21	and	and	CC
cord-310192-8x37nx4s	47	22	molecular	molecular	JJ
cord-310192-8x37nx4s	47	23	topology	topology	NN
cord-310192-8x37nx4s	47	24	,	,	,
cord-310192-8x37nx4s	47	25	among	among	IN
cord-310192-8x37nx4s	47	26	others	other	NNS
cord-310192-8x37nx4s	47	27	.	.	.
cord-310192-8x37nx4s	48	1	Generally	generally	RB
cord-310192-8x37nx4s	48	2	,	,	,
cord-310192-8x37nx4s	48	3	X	x	NN
cord-310192-8x37nx4s	48	4	-	-	NN
cord-310192-8x37nx4s	48	5	ray	ray	NN
cord-310192-8x37nx4s	48	6	crystallography	crystallography	NN
cord-310192-8x37nx4s	48	7	is	be	VBZ
cord-310192-8x37nx4s	48	8	the	the	DT
cord-310192-8x37nx4s	48	9	most	most	RBS
cord-310192-8x37nx4s	48	10	widely	widely	RB
cord-310192-8x37nx4s	48	11	used	use	VBN
cord-310192-8x37nx4s	48	12	method	method	NN
cord-310192-8x37nx4s	48	13	of	of	IN
cord-310192-8x37nx4s	48	14	structure	structure	NN
cord-310192-8x37nx4s	48	15	determination	determination	NN
cord-310192-8x37nx4s	48	16	for	for	IN
cord-310192-8x37nx4s	48	17	biological	biological	JJ
cord-310192-8x37nx4s	48	18	macromolecules	macromolecule	NNS
cord-310192-8x37nx4s	48	19	.	.	.
cord-310192-8x37nx4s	49	1	Indeed	indeed	RB
cord-310192-8x37nx4s	49	2	,	,	,
cord-310192-8x37nx4s	49	3	protein	protein	NN
cord-310192-8x37nx4s	49	4	structure	structure	NN
cord-310192-8x37nx4s	49	5	elucidation	elucidation	NN
cord-310192-8x37nx4s	49	6	has	have	VBZ
cord-310192-8x37nx4s	49	7	been	be	VBN
cord-310192-8x37nx4s	49	8	overwhelmingly	overwhelmingly	RB
cord-310192-8x37nx4s	49	9	conducted	conduct	VBN
cord-310192-8x37nx4s	49	10	using	use	VBG
cord-310192-8x37nx4s	49	11	X	x	NN
cord-310192-8x37nx4s	49	12	-	-	NN
cord-310192-8x37nx4s	49	13	ray	ray	NN
cord-310192-8x37nx4s	49	14	crystallography	crystallography	NN
cord-310192-8x37nx4s	49	15	,	,	,
cord-310192-8x37nx4s	49	16	with	with	IN
cord-310192-8x37nx4s	49	17	approximately	approximately	RB
cord-310192-8x37nx4s	49	18	90	90	CD
cord-310192-8x37nx4s	49	19	%	%	NN
cord-310192-8x37nx4s	49	20	of	of	IN
cord-310192-8x37nx4s	49	21	protein	protein	NN
cord-310192-8x37nx4s	49	22	structures	structure	NNS
cord-310192-8x37nx4s	49	23	having	have	VBG
cord-310192-8x37nx4s	49	24	been	be	VBN
cord-310192-8x37nx4s	49	25	determined	determine	VBN
cord-310192-8x37nx4s	49	26	using	use	VBG
cord-310192-8x37nx4s	49	27	X	x	NN
cord-310192-8x37nx4s	49	28	-	-	NN
cord-310192-8x37nx4s	49	29	ray	ray	NN
cord-310192-8x37nx4s	49	30	crystallography	crystallography	NN
cord-310192-8x37nx4s	49	31	(	(	-LRB-
cord-310192-8x37nx4s	49	32	Berman	Berman	NNP
cord-310192-8x37nx4s	49	33	et	et	NNP
cord-310192-8x37nx4s	49	34	al	al	NNP
cord-310192-8x37nx4s	49	35	.	.	NNP
cord-310192-8x37nx4s	49	36	,	,	,
cord-310192-8x37nx4s	49	37	2000	2000	CD
cord-310192-8x37nx4s	49	38	;	;	:
cord-310192-8x37nx4s	49	39	http://www.rcsb.org	http://www.rcsb.org	NFP
cord-310192-8x37nx4s	49	40	)	)	-RRB-
cord-310192-8x37nx4s	49	41	.	.	.
cord-310192-8x37nx4s	50	1	Crystallography	crystallography	NN
cord-310192-8x37nx4s	50	2	,	,	,
cord-310192-8x37nx4s	50	3	as	as	IN
cord-310192-8x37nx4s	50	4	the	the	DT
cord-310192-8x37nx4s	50	5	name	name	NN
cord-310192-8x37nx4s	50	6	implies	imply	VBZ
cord-310192-8x37nx4s	50	7	,	,	,
cord-310192-8x37nx4s	50	8	requires	require	VBZ
cord-310192-8x37nx4s	50	9	the	the	DT
cord-310192-8x37nx4s	50	10	formation	formation	NN
cord-310192-8x37nx4s	50	11	of	of	IN
cord-310192-8x37nx4s	50	12	an	an	DT
cord-310192-8x37nx4s	50	13	ordered	order	VBN
cord-310192-8x37nx4s	50	14	crystal	crystal	NN
cord-310192-8x37nx4s	50	15	capable	capable	JJ
cord-310192-8x37nx4s	50	16	of	of	IN
cord-310192-8x37nx4s	50	17	diffracting	diffract	VBG
cord-310192-8x37nx4s	50	18	X	X	NNS
cord-310192-8x37nx4s	50	19	-	-	NNS
cord-310192-8x37nx4s	50	20	rays	ray	NNS
cord-310192-8x37nx4s	50	21	.	.	.
cord-310192-8x37nx4s	51	1	This	this	DT
cord-310192-8x37nx4s	51	2	necessitates	necessitate	VBZ
cord-310192-8x37nx4s	51	3	conformational	conformational	JJ
cord-310192-8x37nx4s	51	4	homogeneity	homogeneity	NN
cord-310192-8x37nx4s	51	5	within	within	IN
cord-310192-8x37nx4s	51	6	the	the	DT
cord-310192-8x37nx4s	51	7	crystal	crystal	NN
cord-310192-8x37nx4s	51	8	lattice	lattice	NN
cord-310192-8x37nx4s	51	9	.	.	.
cord-310192-8x37nx4s	52	1	Therefore	therefore	RB
cord-310192-8x37nx4s	52	2	,	,	,
cord-310192-8x37nx4s	52	3	X	x	NN
cord-310192-8x37nx4s	52	4	-	-	NN
cord-310192-8x37nx4s	52	5	ray	ray	NN
cord-310192-8x37nx4s	52	6	crystallography	crystallography	NN
cord-310192-8x37nx4s	52	7	has	have	VBZ
cord-310192-8x37nx4s	52	8	proven	prove	VBN
cord-310192-8x37nx4s	52	9	very	very	RB
cord-310192-8x37nx4s	52	10	useful	useful	JJ
cord-310192-8x37nx4s	52	11	for	for	IN
cord-310192-8x37nx4s	52	12	those	those	DT
cord-310192-8x37nx4s	52	13	RNA	RNA	NNP
cord-310192-8x37nx4s	52	14	molecules	molecule	NNS
cord-310192-8x37nx4s	52	15	that	that	WDT
cord-310192-8x37nx4s	52	16	adopt	adopt	VBP
cord-310192-8x37nx4s	52	17	relatively	relatively	RB
cord-310192-8x37nx4s	52	18	rigid	rigid	JJ
cord-310192-8x37nx4s	52	19	conformation	conformation	NN
cord-310192-8x37nx4s	52	20	,	,	,
cord-310192-8x37nx4s	52	21	for	for	IN
cord-310192-8x37nx4s	52	22	instance	instance	NN
cord-310192-8x37nx4s	52	23	,	,	,
cord-310192-8x37nx4s	52	24	riboswitches	riboswitche	NNS
cord-310192-8x37nx4s	52	25	and	and	CC
cord-310192-8x37nx4s	52	26	catalytic	catalytic	JJ
cord-310192-8x37nx4s	52	27	ribozymes	ribozyme	NNS
cord-310192-8x37nx4s	52	28	(	(	-LRB-
cord-310192-8x37nx4s	52	29	Liberman	Liberman	NNP
cord-310192-8x37nx4s	52	30	&	&	CC
cord-310192-8x37nx4s	52	31	Wedekind	Wedekind	NNP
cord-310192-8x37nx4s	52	32	,	,	,
cord-310192-8x37nx4s	52	33	2012	2012	CD
cord-310192-8x37nx4s	52	34	;	;	:
cord-310192-8x37nx4s	52	35	Marcia	Marcia	NNP
cord-310192-8x37nx4s	52	36	&	&	CC
cord-310192-8x37nx4s	52	37	Pyle	Pyle	NNP
cord-310192-8x37nx4s	52	38	,	,	,
cord-310192-8x37nx4s	52	39	2012	2012	CD
cord-310192-8x37nx4s	52	40	;	;	:
cord-310192-8x37nx4s	52	41	Pyle	Pyle	NNP
cord-310192-8x37nx4s	52	42	,	,	,
cord-310192-8x37nx4s	52	43	2016	2016	CD
cord-310192-8x37nx4s	52	44	;	;	:
cord-310192-8x37nx4s	52	45	Roth	Roth	NNP
cord-310192-8x37nx4s	52	46	&	&	CC
cord-310192-8x37nx4s	52	47	Breaker	Breaker	NNP
cord-310192-8x37nx4s	52	48	,	,	,
cord-310192-8x37nx4s	52	49	2009	2009	CD
cord-310192-8x37nx4s	52	50	;	;	:
cord-310192-8x37nx4s	52	51	Toor	Toor	NNP
cord-310192-8x37nx4s	52	52	,	,	,
cord-310192-8x37nx4s	52	53	Keating	Keating	NNP
cord-310192-8x37nx4s	52	54	,	,	,
cord-310192-8x37nx4s	52	55	Taylor	Taylor	NNP
cord-310192-8x37nx4s	52	56	,	,	,
cord-310192-8x37nx4s	52	57	&	&	CC
cord-310192-8x37nx4s	52	58	Pyle	Pyle	NNP
cord-310192-8x37nx4s	52	59	,	,	,
cord-310192-8x37nx4s	52	60	2008	2008	CD
cord-310192-8x37nx4s	52	61	;	;	:
cord-310192-8x37nx4s	52	62	Toor	Toor	NNP
cord-310192-8x37nx4s	52	63	,	,	,
cord-310192-8x37nx4s	52	64	Rajashankar	Rajashankar	NNP
cord-310192-8x37nx4s	52	65	,	,	,
cord-310192-8x37nx4s	52	66	Keating	Keating	NNP
cord-310192-8x37nx4s	52	67	,	,	,
cord-310192-8x37nx4s	52	68	&	&	CC
cord-310192-8x37nx4s	52	69	Pyle	Pyle	NNP
cord-310192-8x37nx4s	52	70	,	,	,
cord-310192-8x37nx4s	52	71	2008	2008	CD
cord-310192-8x37nx4s	52	72	)	)	-RRB-
cord-310192-8x37nx4s	52	73	.	.	.
cord-310192-8x37nx4s	53	1	However	however	RB
cord-310192-8x37nx4s	53	2	,	,	,
cord-310192-8x37nx4s	53	3	many	many	JJ
cord-310192-8x37nx4s	53	4	RNA	RNA	NNP
cord-310192-8x37nx4s	53	5	molecules	molecule	NNS
cord-310192-8x37nx4s	53	6	,	,	,
cord-310192-8x37nx4s	53	7	particularly	particularly	RB
cord-310192-8x37nx4s	53	8	larger	large	JJR
cord-310192-8x37nx4s	53	9	RNAs	rna	NNS
cord-310192-8x37nx4s	53	10	,	,	,
cord-310192-8x37nx4s	53	11	are	be	VBP
cord-310192-8x37nx4s	53	12	flexible	flexible	JJ
cord-310192-8x37nx4s	53	13	and	and	CC
cord-310192-8x37nx4s	53	14	may	may	MD
cord-310192-8x37nx4s	53	15	sample	sample	VB
cord-310192-8x37nx4s	53	16	multiple	multiple	JJ
cord-310192-8x37nx4s	53	17	conformations	conformation	NNS
cord-310192-8x37nx4s	53	18	and	and	CC
cord-310192-8x37nx4s	53	19	thus	thus	RB
cord-310192-8x37nx4s	53	20	less	less	RBR
cord-310192-8x37nx4s	53	21	likely	likely	JJ
cord-310192-8x37nx4s	53	22	to	to	TO
cord-310192-8x37nx4s	53	23	crystallize	crystallize	VB
cord-310192-8x37nx4s	53	24	in	in	IN
cord-310192-8x37nx4s	53	25	the	the	DT
cord-310192-8x37nx4s	53	26	absence	absence	NN
cord-310192-8x37nx4s	53	27	of	of	IN
cord-310192-8x37nx4s	53	28	stabilizing	stabilize	VBG
cord-310192-8x37nx4s	53	29	cofactors	cofactor	NNS
cord-310192-8x37nx4s	53	30	like	like	IN
cord-310192-8x37nx4s	53	31	protein	protein	NN
cord-310192-8x37nx4s	53	32	binding	bind	VBG
cord-310192-8x37nx4s	53	33	partners	partner	NNS
cord-310192-8x37nx4s	53	34	.	.	.
cord-310192-8x37nx4s	54	1	X	x	NN
cord-310192-8x37nx4s	54	2	-	-	NN
cord-310192-8x37nx4s	54	3	ray	ray	NN
cord-310192-8x37nx4s	54	4	crystallography	crystallography	NN
cord-310192-8x37nx4s	54	5	has	have	VBZ
cord-310192-8x37nx4s	54	6	therefore	therefore	RB
cord-310192-8x37nx4s	54	7	played	play	VBN
cord-310192-8x37nx4s	54	8	an	an	DT
cord-310192-8x37nx4s	54	9	important	important	JJ
cord-310192-8x37nx4s	54	10	,	,	,
cord-310192-8x37nx4s	54	11	but	but	CC
cord-310192-8x37nx4s	54	12	significantly	significantly	RB
cord-310192-8x37nx4s	54	13	smaller	small	JJR
cord-310192-8x37nx4s	54	14	(	(	-LRB-
cord-310192-8x37nx4s	54	15	approximately	approximately	RB
cord-310192-8x37nx4s	54	16	60	60	CD
cord-310192-8x37nx4s	54	17	%	%	NN
cord-310192-8x37nx4s	54	18	of	of	IN
cord-310192-8x37nx4s	54	19	RNA	RNA	NNP
cord-310192-8x37nx4s	54	20	structures	structure	NNS
cord-310192-8x37nx4s	54	21	were	be	VBD
cord-310192-8x37nx4s	54	22	determined	determine	VBN
cord-310192-8x37nx4s	54	23	using	use	VBG
cord-310192-8x37nx4s	54	24	X	x	NN
cord-310192-8x37nx4s	54	25	-	-	NN
cord-310192-8x37nx4s	54	26	ray	ray	NN
cord-310192-8x37nx4s	54	27	crystallography	crystallography	NN
cord-310192-8x37nx4s	54	28	)	)	-RRB-
cord-310192-8x37nx4s	54	29	role	role	NN
cord-310192-8x37nx4s	54	30	in	in	IN
cord-310192-8x37nx4s	54	31	the	the	DT
cord-310192-8x37nx4s	54	32	threedimensional	threedimensional	JJ
cord-310192-8x37nx4s	54	33	structure	structure	NN
cord-310192-8x37nx4s	54	34	determination	determination	NN
cord-310192-8x37nx4s	54	35	of	of	IN
cord-310192-8x37nx4s	54	36	RNAs	rna	NNS
cord-310192-8x37nx4s	54	37	relative	relative	JJ
cord-310192-8x37nx4s	54	38	to	to	IN
cord-310192-8x37nx4s	54	39	proteins	protein	NNS
cord-310192-8x37nx4s	55	1	(	(	-LRB-
cord-310192-8x37nx4s	55	2	Berman	Berman	NNP
cord-310192-8x37nx4s	55	3	et	et	NNP
cord-310192-8x37nx4s	55	4	al	al	NNP
cord-310192-8x37nx4s	55	5	.	.	NNP
cord-310192-8x37nx4s	55	6	,	,	,
cord-310192-8x37nx4s	55	7	2000	2000	CD
cord-310192-8x37nx4s	55	8	;	;	:
cord-310192-8x37nx4s	55	9	http://www.rcsb.org	http://www.rcsb.org	XX
cord-310192-8x37nx4s	55	10	 	 	_SP
cord-310192-8x37nx4s	56	1	Single	single	JJ
cord-310192-8x37nx4s	56	2	particle	particle	NN
cord-310192-8x37nx4s	56	3	cryo	cryo	NN
cord-310192-8x37nx4s	56	4	-	-	HYPH
cord-310192-8x37nx4s	56	5	electron	electron	NN
cord-310192-8x37nx4s	56	6	microscopy	microscopy	NN
cord-310192-8x37nx4s	56	7	(	(	-LRB-
cord-310192-8x37nx4s	56	8	cryo	cryo	NN
cord-310192-8x37nx4s	56	9	-	-	HYPH
cord-310192-8x37nx4s	56	10	EM	EM	NNP
cord-310192-8x37nx4s	56	11	)	)	-RRB-
cord-310192-8x37nx4s	56	12	is	be	VBZ
cord-310192-8x37nx4s	56	13	a	a	DT
cord-310192-8x37nx4s	56	14	powerful	powerful	JJ
cord-310192-8x37nx4s	56	15	technique	technique	NN
cord-310192-8x37nx4s	56	16	for	for	IN
cord-310192-8x37nx4s	56	17	structure	structure	NN
cord-310192-8x37nx4s	56	18	elucidation	elucidation	NN
cord-310192-8x37nx4s	56	19	of	of	IN
cord-310192-8x37nx4s	56	20	large	large	JJ
cord-310192-8x37nx4s	56	21	biomolecules	biomolecule	NNS
cord-310192-8x37nx4s	56	22	and	and	CC
cord-310192-8x37nx4s	56	23	biomolecular	biomolecular	JJ
cord-310192-8x37nx4s	56	24	machines	machine	NNS
cord-310192-8x37nx4s	56	25	,	,	,
cord-310192-8x37nx4s	56	26	and	and	CC
cord-310192-8x37nx4s	56	27	recent	recent	JJ
cord-310192-8x37nx4s	56	28	technological	technological	JJ
cord-310192-8x37nx4s	56	29	advances	advance	NNS
cord-310192-8x37nx4s	56	30	have	have	VBP
cord-310192-8x37nx4s	56	31	catapulted	catapult	VBN
cord-310192-8x37nx4s	56	32	this	this	DT
cord-310192-8x37nx4s	56	33	technique	technique	NN
cord-310192-8x37nx4s	56	34	to	to	IN
cord-310192-8x37nx4s	56	35	the	the	DT
cord-310192-8x37nx4s	56	36	forefront	forefront	NN
cord-310192-8x37nx4s	56	37	of	of	IN
cord-310192-8x37nx4s	56	38	structural	structural	JJ
cord-310192-8x37nx4s	56	39	biology	biology	NN
cord-310192-8x37nx4s	56	40	(	(	-LRB-
cord-310192-8x37nx4s	56	41	Kuhlbrandt	Kuhlbrandt	NNP
cord-310192-8x37nx4s	56	42	,	,	,
cord-310192-8x37nx4s	56	43	2014a	2014a	CD
cord-310192-8x37nx4s	56	44	(	(	-LRB-
cord-310192-8x37nx4s	56	45	Kuhlbrandt	Kuhlbrandt	NNP
cord-310192-8x37nx4s	56	46	,	,	,
cord-310192-8x37nx4s	56	47	,	,	,
cord-310192-8x37nx4s	56	48	2014b	2014b	CD
cord-310192-8x37nx4s	56	49	Nogales	Nogales	NNP
cord-310192-8x37nx4s	56	50	&	&	CC
cord-310192-8x37nx4s	56	51	Scheres	Scheres	NNPS
cord-310192-8x37nx4s	56	52	,	,	,
cord-310192-8x37nx4s	56	53	2015	2015	CD
cord-310192-8x37nx4s	56	54	;	;	:
cord-310192-8x37nx4s	56	55	Vinothkumar	Vinothkumar	NNP
cord-310192-8x37nx4s	56	56	&	&	CC
cord-310192-8x37nx4s	56	57	Henderson	Henderson	NNP
cord-310192-8x37nx4s	56	58	,	,	,
cord-310192-8x37nx4s	56	59	2016	2016	CD
cord-310192-8x37nx4s	56	60	)	)	-RRB-
cord-310192-8x37nx4s	56	61	.	.	.
cord-310192-8x37nx4s	57	1	Cryo	cryo	NN
cord-310192-8x37nx4s	57	2	-	-	HYPH
cord-310192-8x37nx4s	57	3	EM	EM	NNP
cord-310192-8x37nx4s	57	4	importantly	importantly	RB
cord-310192-8x37nx4s	57	5	allows	allow	VBZ
cord-310192-8x37nx4s	57	6	for	for	IN
cord-310192-8x37nx4s	57	7	the	the	DT
cord-310192-8x37nx4s	57	8	visualization	visualization	NN
cord-310192-8x37nx4s	57	9	of	of	IN
cord-310192-8x37nx4s	57	10	dynamic	dynamic	JJ
cord-310192-8x37nx4s	57	11	biological	biological	JJ
cord-310192-8x37nx4s	57	12	processes	process	NNS
cord-310192-8x37nx4s	57	13	by	by	IN
cord-310192-8x37nx4s	57	14	direct	direct	JJ
cord-310192-8x37nx4s	57	15	visualization	visualization	NN
cord-310192-8x37nx4s	57	16	of	of	IN
cord-310192-8x37nx4s	57	17	biomolecules	biomolecule	NNS
cord-310192-8x37nx4s	57	18	with	with	IN
cord-310192-8x37nx4s	57	19	multiple	multiple	JJ
cord-310192-8x37nx4s	57	20	structural	structural	JJ
cord-310192-8x37nx4s	57	21	states	state	NNS
cord-310192-8x37nx4s	57	22	(	(	-LRB-
cord-310192-8x37nx4s	57	23	Dong	Dong	NNP
cord-310192-8x37nx4s	57	24	et	et	FW
cord-310192-8x37nx4s	57	25	al	al	NNP
cord-310192-8x37nx4s	57	26	.	.	NNP
cord-310192-8x37nx4s	57	27	,	,	,
cord-310192-8x37nx4s	57	28	2019	2019	CD
cord-310192-8x37nx4s	57	29	;	;	:
cord-310192-8x37nx4s	57	30	Nakanishi	Nakanishi	NNP
cord-310192-8x37nx4s	57	31	,	,	,
cord-310192-8x37nx4s	57	32	Kishikawa	Kishikawa	NNP
cord-310192-8x37nx4s	57	33	,	,	,
cord-310192-8x37nx4s	57	34	Tamakoshi	Tamakoshi	NNP
cord-310192-8x37nx4s	57	35	,	,	,
cord-310192-8x37nx4s	57	36	Mitsuoka	Mitsuoka	NNP
cord-310192-8x37nx4s	57	37	,	,	,
cord-310192-8x37nx4s	57	38	&	&	CC
cord-310192-8x37nx4s	57	39	Yokoyama	Yokoyama	NNP
cord-310192-8x37nx4s	57	40	,	,	,
cord-310192-8x37nx4s	57	41	2018	2018	CD
cord-310192-8x37nx4s	57	42	;	;	:
cord-310192-8x37nx4s	57	43	Roh	Roh	NNP
cord-310192-8x37nx4s	57	44	et	et	NNP
cord-310192-8x37nx4s	57	45	al	al	NNP
cord-310192-8x37nx4s	57	46	.	.	NNP
cord-310192-8x37nx4s	57	47	,	,	,
cord-310192-8x37nx4s	57	48	2017	2017	CD
cord-310192-8x37nx4s	57	49	)	)	-RRB-
cord-310192-8x37nx4s	57	50	.	.	.
cord-310192-8x37nx4s	58	1	However	however	RB
cord-310192-8x37nx4s	58	2	,	,	,
cord-310192-8x37nx4s	58	3	to	to	IN
cord-310192-8x37nx4s	58	4	date	date	NN
cord-310192-8x37nx4s	58	5	,	,	,
cord-310192-8x37nx4s	58	6	cryo	cryo	NN
cord-310192-8x37nx4s	58	7	-	-	HYPH
cord-310192-8x37nx4s	58	8	EM	EM	NNP
cord-310192-8x37nx4s	58	9	has	have	VBZ
cord-310192-8x37nx4s	58	10	largely	largely	RB
cord-310192-8x37nx4s	58	11	been	be	VBN
cord-310192-8x37nx4s	58	12	applied	apply	VBN
cord-310192-8x37nx4s	58	13	to	to	IN
cord-310192-8x37nx4s	58	14	protein	protein	NN
cord-310192-8x37nx4s	58	15	only	only	RB
cord-310192-8x37nx4s	58	16	or	or	CC
cord-310192-8x37nx4s	58	17	protein	protein	NN
cord-310192-8x37nx4s	58	18	-	-	HYPH
cord-310192-8x37nx4s	58	19	nucleic	nucleic	JJ
cord-310192-8x37nx4s	58	20	acid	acid	NN
cord-310192-8x37nx4s	58	21	complexes	complex	NNS
cord-310192-8x37nx4s	58	22	(	(	-LRB-
cord-310192-8x37nx4s	58	23	e.g.	e.g.	RB
cord-310192-8x37nx4s	58	24	,	,	,
cord-310192-8x37nx4s	58	25	the	the	DT
cord-310192-8x37nx4s	58	26	ribosome	ribosome	NN
cord-310192-8x37nx4s	58	27	and	and	CC
cord-310192-8x37nx4s	58	28	spliceosome	spliceosome	NNP
cord-310192-8x37nx4s	58	29	)	)	-RRB-
cord-310192-8x37nx4s	58	30	.	.	.
cord-310192-8x37nx4s	59	1	Cryo	cryo	NN
cord-310192-8x37nx4s	59	2	-	-	HYPH
cord-310192-8x37nx4s	59	3	EM	EM	NNP
cord-310192-8x37nx4s	59	4	has	have	VBZ
cord-310192-8x37nx4s	59	5	been	be	VBN
cord-310192-8x37nx4s	59	6	used	use	VBN
cord-310192-8x37nx4s	59	7	to	to	TO
cord-310192-8x37nx4s	59	8	study	study	VB
cord-310192-8x37nx4s	59	9	the	the	DT
cord-310192-8x37nx4s	59	10	overall	overall	JJ
cord-310192-8x37nx4s	59	11	size	size	NN
cord-310192-8x37nx4s	59	12	and	and	CC
cord-310192-8x37nx4s	59	13	shape	shape	NN
cord-310192-8x37nx4s	59	14	of	of	IN
cord-310192-8x37nx4s	59	15	very	very	RB
cord-310192-8x37nx4s	59	16	large	large	JJ
cord-310192-8x37nx4s	59	17	RNAs	rna	NNS
cord-310192-8x37nx4s	59	18	,	,	,
cord-310192-8x37nx4s	59	19	reporting	report	VBG
cord-310192-8x37nx4s	59	20	at	at	IN
cord-310192-8x37nx4s	59	21	very	very	RB
cord-310192-8x37nx4s	59	22	low	low	JJ
cord-310192-8x37nx4s	59	23	resolution	resolution	NN
cord-310192-8x37nx4s	59	24	on	on	IN
cord-310192-8x37nx4s	59	25	secondary	secondary	JJ
cord-310192-8x37nx4s	59	26	structure	structure	NN
cord-310192-8x37nx4s	59	27	and	and	CC
cord-310192-8x37nx4s	59	28	branching	branching	NN
cord-310192-8x37nx4s	59	29	pattern	pattern	NN
cord-310192-8x37nx4s	59	30	of	of	IN
cord-310192-8x37nx4s	59	31	these	these	DT
cord-310192-8x37nx4s	59	32	RNAs	rna	NNS
cord-310192-8x37nx4s	59	33	(	(	-LRB-
cord-310192-8x37nx4s	59	34	Garmann	Garmann	NNP
cord-310192-8x37nx4s	59	35	et	et	FW
cord-310192-8x37nx4s	59	36	al	al	NNP
cord-310192-8x37nx4s	59	37	.	.	NNP
cord-310192-8x37nx4s	59	38	,	,	,
cord-310192-8x37nx4s	59	39	2015	2015	CD
cord-310192-8x37nx4s	59	40	;	;	:
cord-310192-8x37nx4s	59	41	Gopal	Gopal	NNP
cord-310192-8x37nx4s	59	42	,	,	,
cord-310192-8x37nx4s	59	43	Zhou	Zhou	NNP
cord-310192-8x37nx4s	59	44	,	,	,
cord-310192-8x37nx4s	59	45	Knobler	Knobler	NNP
cord-310192-8x37nx4s	59	46	,	,	,
cord-310192-8x37nx4s	59	47	&	&	CC
cord-310192-8x37nx4s	59	48	Gelbart	Gelbart	NNP
cord-310192-8x37nx4s	59	49	,	,	,
cord-310192-8x37nx4s	59	50	2012	2012	CD
cord-310192-8x37nx4s	59	51	)	)	-RRB-
cord-310192-8x37nx4s	59	52	.	.	.
cord-310192-8x37nx4s	60	1	There	there	EX
cord-310192-8x37nx4s	60	2	are	be	VBP
cord-310192-8x37nx4s	60	3	a	a	DT
cord-310192-8x37nx4s	60	4	few	few	JJ
cord-310192-8x37nx4s	60	5	structures	structure	NNS
cord-310192-8x37nx4s	60	6	of	of	IN
cord-310192-8x37nx4s	60	7	relatively	relatively	RB
cord-310192-8x37nx4s	60	8	small	small	JJ
cord-310192-8x37nx4s	60	9	RNAs	rna	NNS
cord-310192-8x37nx4s	60	10	derived	derive	VBN
cord-310192-8x37nx4s	60	11	from	from	IN
cord-310192-8x37nx4s	60	12	cryo	cryo	NN
cord-310192-8x37nx4s	60	13	-	-	HYPH
cord-310192-8x37nx4s	60	14	EM	EM	NNP
cord-310192-8x37nx4s	60	15	data	datum	NNS
cord-310192-8x37nx4s	60	16	,	,	,
cord-310192-8x37nx4s	60	17	(	(	-LRB-
cord-310192-8x37nx4s	60	18	Baird	Baird	NNP
cord-310192-8x37nx4s	60	19	et	et	NNP
cord-310192-8x37nx4s	60	20	al	al	NNP
cord-310192-8x37nx4s	60	21	.	.	NNP
cord-310192-8x37nx4s	60	22	,	,	,
cord-310192-8x37nx4s	60	23	2010	2010	CD
cord-310192-8x37nx4s	60	24	;	;	:
cord-310192-8x37nx4s	60	25	Zhang	Zhang	NNP
cord-310192-8x37nx4s	60	26	et	et	NNP
cord-310192-8x37nx4s	60	27	al	al	NNP
cord-310192-8x37nx4s	60	28	.	.	NNP
cord-310192-8x37nx4s	60	29	,	,	,
cord-310192-8x37nx4s	60	30	2018	2018	CD
cord-310192-8x37nx4s	60	31	)	)	-RRB-
cord-310192-8x37nx4s	60	32	but	but	CC
cord-310192-8x37nx4s	60	33	these	these	DT
cord-310192-8x37nx4s	60	34	low	low	JJ
cord-310192-8x37nx4s	60	35	resolution	resolution	NN
cord-310192-8x37nx4s	60	36	density	density	NN
cord-310192-8x37nx4s	60	37	maps	map	NNS
cord-310192-8x37nx4s	60	38	harbor	harbor	VBP
cord-310192-8x37nx4s	60	39	limited	limited	JJ
cord-310192-8x37nx4s	60	40	structural	structural	JJ
cord-310192-8x37nx4s	60	41	detail	detail	NN
cord-310192-8x37nx4s	60	42	requiring	require	VBG
cord-310192-8x37nx4s	60	43	higher	high	JJR
cord-310192-8x37nx4s	60	44	resolution	resolution	NN
cord-310192-8x37nx4s	60	45	models	model	NNS
cord-310192-8x37nx4s	60	46	determined	determine	VBN
cord-310192-8x37nx4s	60	47	via	via	IN
cord-310192-8x37nx4s	60	48	other	other	JJ
cord-310192-8x37nx4s	60	49	methods	method	NNS
cord-310192-8x37nx4s	60	50	to	to	TO
cord-310192-8x37nx4s	60	51	glean	glean	VB
cord-310192-8x37nx4s	60	52	mechanistic	mechanistic	JJ
cord-310192-8x37nx4s	60	53	insight	insight	NN
cord-310192-8x37nx4s	60	54	.	.	.
cord-310192-8x37nx4s	61	1	A	a	DT
cord-310192-8x37nx4s	61	2	recent	recent	JJ
cord-310192-8x37nx4s	61	3	software	software	NN
cord-310192-8x37nx4s	61	4	developed	develop	VBN
cord-310192-8x37nx4s	61	5	by	by	IN
cord-310192-8x37nx4s	61	6	the	the	DT
cord-310192-8x37nx4s	61	7	Das	Das	NNP
cord-310192-8x37nx4s	61	8	lab	lab	NN
cord-310192-8x37nx4s	61	9	facilitates	facilitate	VBZ
cord-310192-8x37nx4s	61	10	the	the	DT
cord-310192-8x37nx4s	61	11	building	building	NN
cord-310192-8x37nx4s	61	12	of	of	IN
cord-310192-8x37nx4s	61	13	RNA	RNA	NNP
cord-310192-8x37nx4s	61	14	coordinates	coordinate	VBZ
cord-310192-8x37nx4s	61	15	into	into	IN
cord-310192-8x37nx4s	61	16	low	low	JJ
cord-310192-8x37nx4s	61	17	resolution	resolution	NN
cord-310192-8x37nx4s	61	18	cryo	cryo	NN
cord-310192-8x37nx4s	61	19	-	-	HYPH
cord-310192-8x37nx4s	61	20	EM	em	NN
cord-310192-8x37nx4s	61	21	density	density	NN
cord-310192-8x37nx4s	62	1	(	(	-LRB-
cord-310192-8x37nx4s	62	2	Kappel	Kappel	NNP
cord-310192-8x37nx4s	62	3	et	et	FW
cord-310192-8x37nx4s	62	4	al	al	NNP
cord-310192-8x37nx4s	62	5	.	.	NNP
cord-310192-8x37nx4s	62	6	,	,	,
cord-310192-8x37nx4s	62	7	2018	2018	CD
cord-310192-8x37nx4s	62	8	)	)	-RRB-
cord-310192-8x37nx4s	62	9	.	.	.
cord-310192-8x37nx4s	63	1	While	while	IN
cord-310192-8x37nx4s	63	2	this	this	DT
cord-310192-8x37nx4s	63	3	technique	technique	NN
cord-310192-8x37nx4s	63	4	is	be	VBZ
cord-310192-8x37nx4s	63	5	described	describe	VBN
cord-310192-8x37nx4s	63	6	for	for	IN
cord-310192-8x37nx4s	63	7	protein	protein	NN
cord-310192-8x37nx4s	63	8	-	-	HYPH
cord-310192-8x37nx4s	63	9	RNA	rna	NN
cord-310192-8x37nx4s	63	10	complex	complex	JJ
cord-310192-8x37nx4s	63	11	datasets	dataset	NNS
cord-310192-8x37nx4s	63	12	,	,	,
cord-310192-8x37nx4s	63	13	it	-PRON-	PRP
cord-310192-8x37nx4s	63	14	is	be	VBZ
cord-310192-8x37nx4s	63	15	likely	likely	RB
cord-310192-8x37nx4s	63	16	applicable	applicable	JJ
cord-310192-8x37nx4s	63	17	to	to	IN
cord-310192-8x37nx4s	63	18	RNA	rna	NN
cord-310192-8x37nx4s	63	19	-	-	HYPH
cord-310192-8x37nx4s	63	20	only	only	JJ
cord-310192-8x37nx4s	63	21	density	density	NN
cord-310192-8x37nx4s	63	22	maps	map	NNS
cord-310192-8x37nx4s	63	23	.	.	.
cord-310192-8x37nx4s	64	1	NMR	NMR	NNP
cord-310192-8x37nx4s	64	2	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	64	3	is	be	VBZ
cord-310192-8x37nx4s	64	4	another	another	DT
cord-310192-8x37nx4s	64	5	common	common	JJ
cord-310192-8x37nx4s	64	6	method	method	NN
cord-310192-8x37nx4s	64	7	for	for	IN
cord-310192-8x37nx4s	64	8	determining	determine	VBG
cord-310192-8x37nx4s	64	9	RNA	RNA	NNP
cord-310192-8x37nx4s	64	10	structure	structure	NN
cord-310192-8x37nx4s	64	11	at	at	IN
cord-310192-8x37nx4s	64	12	atomic	atomic	JJ
cord-310192-8x37nx4s	64	13	resolution	resolution	NN
cord-310192-8x37nx4s	64	14	.	.	.
cord-310192-8x37nx4s	65	1	NMR	NMR	NNP
cord-310192-8x37nx4s	65	2	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	65	3	is	be	VBZ
cord-310192-8x37nx4s	65	4	particularly	particularly	RB
cord-310192-8x37nx4s	65	5	well	well	RB
cord-310192-8x37nx4s	65	6	-	-	HYPH
cord-310192-8x37nx4s	65	7	suited	suit	VBN
cord-310192-8x37nx4s	65	8	for	for	IN
cord-310192-8x37nx4s	65	9	the	the	DT
cord-310192-8x37nx4s	65	10	study	study	NN
cord-310192-8x37nx4s	65	11	of	of	IN
cord-310192-8x37nx4s	65	12	biomolecules	biomolecule	NNS
cord-310192-8x37nx4s	65	13	that	that	WDT
cord-310192-8x37nx4s	65	14	are	be	VBP
cord-310192-8x37nx4s	65	15	not	not	RB
cord-310192-8x37nx4s	65	16	prone	prone	JJ
cord-310192-8x37nx4s	65	17	to	to	IN
cord-310192-8x37nx4s	65	18	crystallization	crystallization	NN
cord-310192-8x37nx4s	65	19	or	or	CC
cord-310192-8x37nx4s	65	20	those	those	DT
cord-310192-8x37nx4s	65	21	which	which	WDT
cord-310192-8x37nx4s	65	22	require	require	VBP
cord-310192-8x37nx4s	65	23	specific	specific	JJ
cord-310192-8x37nx4s	65	24	sample	sample	NN
cord-310192-8x37nx4s	65	25	conditions	condition	NNS
cord-310192-8x37nx4s	65	26	to	to	TO
cord-310192-8x37nx4s	65	27	maintain	maintain	VB
cord-310192-8x37nx4s	65	28	the	the	DT
cord-310192-8x37nx4s	65	29	structure	structure	NN
cord-310192-8x37nx4s	65	30	.	.	.
cord-310192-8x37nx4s	66	1	Compared	compare	VBN
cord-310192-8x37nx4s	66	2	to	to	IN
cord-310192-8x37nx4s	66	3	proteins	protein	NNS
cord-310192-8x37nx4s	66	4	,	,	,
cord-310192-8x37nx4s	66	5	NMR	NMR	NNP
cord-310192-8x37nx4s	66	6	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	66	7	has	have	VBZ
cord-310192-8x37nx4s	66	8	played	play	VBN
cord-310192-8x37nx4s	66	9	a	a	DT
cord-310192-8x37nx4s	66	10	large	large	JJ
cord-310192-8x37nx4s	66	11	role	role	NN
cord-310192-8x37nx4s	66	12	in	in	IN
cord-310192-8x37nx4s	66	13	the	the	DT
cord-310192-8x37nx4s	66	14	structure	structure	NN
cord-310192-8x37nx4s	66	15	determination	determination	NN
cord-310192-8x37nx4s	66	16	of	of	IN
cord-310192-8x37nx4s	66	17	RNA	RNA	NNP
cord-310192-8x37nx4s	66	18	molecules	molecule	NNS
cord-310192-8x37nx4s	66	19	,	,	,
cord-310192-8x37nx4s	66	20	roughly	roughly	RB
cord-310192-8x37nx4s	66	21	40	40	CD
cord-310192-8x37nx4s	66	22	%	%	NN
cord-310192-8x37nx4s	66	23	of	of	IN
cord-310192-8x37nx4s	66	24	RNA	RNA	NNP
cord-310192-8x37nx4s	66	25	structures	structure	NNS
cord-310192-8x37nx4s	66	26	have	have	VBP
cord-310192-8x37nx4s	66	27	been	be	VBN
cord-310192-8x37nx4s	66	28	solved	solve	VBN
cord-310192-8x37nx4s	66	29	using	use	VBG
cord-310192-8x37nx4s	66	30	this	this	DT
cord-310192-8x37nx4s	66	31	method	method	NN
cord-310192-8x37nx4s	66	32	(	(	-LRB-
cord-310192-8x37nx4s	66	33	Berman	Berman	NNP
cord-310192-8x37nx4s	66	34	et	et	NNP
cord-310192-8x37nx4s	66	35	al	al	NNP
cord-310192-8x37nx4s	66	36	.	.	NNP
cord-310192-8x37nx4s	66	37	,	,	,
cord-310192-8x37nx4s	66	38	2000	2000	CD
cord-310192-8x37nx4s	66	39	;	;	:
cord-310192-8x37nx4s	66	40	http://	http://	NNP
cord-310192-8x37nx4s	66	41	www.rcsb.org	www.rcsb.org	NNP
cord-310192-8x37nx4s	66	42	)	)	-RRB-
cord-310192-8x37nx4s	66	43	.	.	.
cord-310192-8x37nx4s	67	1	Importantly	importantly	RB
cord-310192-8x37nx4s	67	2	,	,	,
cord-310192-8x37nx4s	67	3	NMR	NMR	NNP
cord-310192-8x37nx4s	67	4	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	67	5	provides	provide	VBZ
cord-310192-8x37nx4s	67	6	far	far	RB
cord-310192-8x37nx4s	67	7	more	more	JJR
cord-310192-8x37nx4s	67	8	than	than	IN
cord-310192-8x37nx4s	67	9	just	just	RB
cord-310192-8x37nx4s	67	10	structural	structural	JJ
cord-310192-8x37nx4s	67	11	information	information	NN
cord-310192-8x37nx4s	67	12	,	,	,
cord-310192-8x37nx4s	67	13	as	as	IN
cord-310192-8x37nx4s	67	14	it	-PRON-	PRP
cord-310192-8x37nx4s	67	15	allows	allow	VBZ
cord-310192-8x37nx4s	67	16	the	the	DT
cord-310192-8x37nx4s	67	17	dynamics	dynamic	NNS
cord-310192-8x37nx4s	67	18	of	of	IN
cord-310192-8x37nx4s	67	19	the	the	DT
cord-310192-8x37nx4s	67	20	biomolecule	biomolecule	NN
cord-310192-8x37nx4s	67	21	to	to	TO
cord-310192-8x37nx4s	67	22	be	be	VB
cord-310192-8x37nx4s	67	23	studied	study	VBN
cord-310192-8x37nx4s	67	24	as	as	RB
cord-310192-8x37nx4s	67	25	well	well	RB
cord-310192-8x37nx4s	67	26	.	.	.
cord-310192-8x37nx4s	68	1	While	while	IN
cord-310192-8x37nx4s	68	2	NMR	NMR	NNP
cord-310192-8x37nx4s	68	3	is	be	VBZ
cord-310192-8x37nx4s	68	4	a	a	DT
cord-310192-8x37nx4s	68	5	powerful	powerful	JJ
cord-310192-8x37nx4s	68	6	tool	tool	NN
cord-310192-8x37nx4s	68	7	for	for	IN
cord-310192-8x37nx4s	68	8	studying	study	VBG
cord-310192-8x37nx4s	68	9	RNA	RNA	NNP
cord-310192-8x37nx4s	68	10	structure	structure	NN
cord-310192-8x37nx4s	68	11	and	and	CC
cord-310192-8x37nx4s	68	12	dynamics	dynamic	NNS
cord-310192-8x37nx4s	68	13	at	at	IN
cord-310192-8x37nx4s	68	14	the	the	DT
cord-310192-8x37nx4s	68	15	atomic	atomic	JJ
cord-310192-8x37nx4s	68	16	level	level	NN
cord-310192-8x37nx4s	68	17	,	,	,
cord-310192-8x37nx4s	68	18	there	there	EX
cord-310192-8x37nx4s	68	19	are	be	VBP
cord-310192-8x37nx4s	68	20	some	some	DT
cord-310192-8x37nx4s	68	21	very	very	RB
cord-310192-8x37nx4s	68	22	real	real	JJ
cord-310192-8x37nx4s	68	23	challenges	challenge	NNS
cord-310192-8x37nx4s	68	24	/	/	SYM
cord-310192-8x37nx4s	68	25	limitations	limitation	NNS
cord-310192-8x37nx4s	68	26	when	when	WRB
cord-310192-8x37nx4s	68	27	using	use	VBG
cord-310192-8x37nx4s	68	28	NMR	NMR	NNP
cord-310192-8x37nx4s	68	29	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	68	30	to	to	TO
cord-310192-8x37nx4s	68	31	determine	determine	VB
cord-310192-8x37nx4s	68	32	the	the	DT
cord-310192-8x37nx4s	68	33	structure	structure	NN
cord-310192-8x37nx4s	68	34	and	and	CC
cord-310192-8x37nx4s	68	35	dynamics	dynamic	NNS
cord-310192-8x37nx4s	68	36	of	of	IN
cord-310192-8x37nx4s	68	37	large	large	JJ
cord-310192-8x37nx4s	68	38	RNAs	rna	NNS
cord-310192-8x37nx4s	68	39	.	.	.
cord-310192-8x37nx4s	69	1	(	(	-LRB-
cord-310192-8x37nx4s	69	2	a	a	LS
cord-310192-8x37nx4s	69	3	)	)	-RRB-
cord-310192-8x37nx4s	69	4	Labor	labor	NN
cord-310192-8x37nx4s	69	5	intensive	intensive	JJ
cord-310192-8x37nx4s	69	6	.	.	.
cord-310192-8x37nx4s	70	1	Structure	structure	NN
cord-310192-8x37nx4s	70	2	elucidation	elucidation	NN
cord-310192-8x37nx4s	70	3	by	by	IN
cord-310192-8x37nx4s	70	4	NMR	NMR	NNP
cord-310192-8x37nx4s	70	5	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	70	6	requires	require	VBZ
cord-310192-8x37nx4s	70	7	that	that	IN
cord-310192-8x37nx4s	70	8	most	most	JJS
cord-310192-8x37nx4s	70	9	resonances	resonance	NNS
cord-310192-8x37nx4s	70	10	are	be	VBP
cord-310192-8x37nx4s	70	11	assigned	assign	VBN
cord-310192-8x37nx4s	70	12	before	before	IN
cord-310192-8x37nx4s	70	13	beginning	begin	VBG
cord-310192-8x37nx4s	70	14	any	any	DT
cord-310192-8x37nx4s	70	15	structural	structural	JJ
cord-310192-8x37nx4s	70	16	analysis	analysis	NN
cord-310192-8x37nx4s	70	17	.	.	.
cord-310192-8x37nx4s	71	1	This	this	DT
cord-310192-8x37nx4s	71	2	is	be	VBZ
cord-310192-8x37nx4s	71	3	a	a	DT
cord-310192-8x37nx4s	71	4	time	time	NN
cord-310192-8x37nx4s	71	5	-	-	HYPH
cord-310192-8x37nx4s	71	6	consuming	consume	VBG
cord-310192-8x37nx4s	71	7	process	process	NN
cord-310192-8x37nx4s	71	8	both	both	DT
cord-310192-8x37nx4s	71	9	as	as	IN
cord-310192-8x37nx4s	71	10	it	-PRON-	PRP
cord-310192-8x37nx4s	71	11	relates	relate	VBZ
cord-310192-8x37nx4s	71	12	to	to	IN
cord-310192-8x37nx4s	71	13	data	datum	NNS
cord-310192-8x37nx4s	71	14	acquisition	acquisition	NN
cord-310192-8x37nx4s	71	15	and	and	CC
cord-310192-8x37nx4s	71	16	data	data	NN
cord-310192-8x37nx4s	71	17	analysis	analysis	NN
cord-310192-8x37nx4s	71	18	.	.	.
cord-310192-8x37nx4s	72	1	(	(	-LRB-
cord-310192-8x37nx4s	72	2	b	b	LS
cord-310192-8x37nx4s	72	3	)	)	-RRB-
cord-310192-8x37nx4s	72	4	Signal	signal	NN
cord-310192-8x37nx4s	72	5	overlap	overlap	NN
cord-310192-8x37nx4s	72	6	.	.	.
cord-310192-8x37nx4s	73	1	RNAs	rna	NNS
cord-310192-8x37nx4s	73	2	are	be	VBP
cord-310192-8x37nx4s	73	3	built	build	VBN
cord-310192-8x37nx4s	73	4	from	from	IN
cord-310192-8x37nx4s	73	5	four	four	CD
cord-310192-8x37nx4s	73	6	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	73	7	which	which	WDT
cord-310192-8x37nx4s	73	8	have	have	VBP
cord-310192-8x37nx4s	73	9	similar	similar	JJ
cord-310192-8x37nx4s	73	10	chemical	chemical	JJ
cord-310192-8x37nx4s	73	11	structures	structure	NNS
cord-310192-8x37nx4s	73	12	.	.	.
cord-310192-8x37nx4s	74	1	This	this	DT
cord-310192-8x37nx4s	74	2	results	result	VBZ
cord-310192-8x37nx4s	74	3	in	in	IN
cord-310192-8x37nx4s	74	4	a	a	DT
cord-310192-8x37nx4s	74	5	lack	lack	NN
cord-310192-8x37nx4s	74	6	of	of	IN
cord-310192-8x37nx4s	74	7	dispersion	dispersion	NN
cord-310192-8x37nx4s	74	8	in	in	IN
cord-310192-8x37nx4s	74	9	the	the	DT
cord-310192-8x37nx4s	74	10	chemical	chemical	NN
cord-310192-8x37nx4s	74	11	shifts	shift	NNS
cord-310192-8x37nx4s	74	12	(	(	-LRB-
cord-310192-8x37nx4s	74	13	also	also	RB
cord-310192-8x37nx4s	74	14	known	know	VBN
cord-310192-8x37nx4s	74	15	as	as	IN
cord-310192-8x37nx4s	74	16	signal	signal	NN
cord-310192-8x37nx4s	74	17	degeneracy	degeneracy	NN
cord-310192-8x37nx4s	74	18	)	)	-RRB-
cord-310192-8x37nx4s	74	19	.	.	.
cord-310192-8x37nx4s	75	1	(	(	-LRB-
cord-310192-8x37nx4s	75	2	c	c	NN
cord-310192-8x37nx4s	75	3	)	)	-RRB-
cord-310192-8x37nx4s	76	1	Unfavorable	unfavorable	JJ
cord-310192-8x37nx4s	76	2	relaxation	relaxation	NN
cord-310192-8x37nx4s	76	3	properties	property	NNS
cord-310192-8x37nx4s	76	4	.	.	.
cord-310192-8x37nx4s	77	1	Large	large	JJ
cord-310192-8x37nx4s	77	2	RNA	RNA	NNP
cord-310192-8x37nx4s	77	3	molecules	molecule	NNS
cord-310192-8x37nx4s	77	4	tumble	tumble	VBP
cord-310192-8x37nx4s	77	5	very	very	RB
cord-310192-8x37nx4s	77	6	slowly	slowly	RB
cord-310192-8x37nx4s	77	7	in	in	IN
cord-310192-8x37nx4s	77	8	solution	solution	NN
cord-310192-8x37nx4s	77	9	leading	lead	VBG
cord-310192-8x37nx4s	77	10	to	to	IN
cord-310192-8x37nx4s	77	11	severe	severe	JJ
cord-310192-8x37nx4s	77	12	broadening	broadening	NN
cord-310192-8x37nx4s	77	13	of	of	IN
cord-310192-8x37nx4s	77	14	signals	signal	NNS
cord-310192-8x37nx4s	77	15	and	and	CC
cord-310192-8x37nx4s	77	16	significant	significant	JJ
cord-310192-8x37nx4s	77	17	losses	loss	NNS
cord-310192-8x37nx4s	77	18	in	in	IN
cord-310192-8x37nx4s	77	19	signal	signal	JJ
cord-310192-8x37nx4s	77	20	intensity	intensity	NN
cord-310192-8x37nx4s	77	21	.	.	.
cord-310192-8x37nx4s	78	1	These	these	DT
cord-310192-8x37nx4s	78	2	challenges	challenge	NNS
cord-310192-8x37nx4s	78	3	have	have	VBP
cord-310192-8x37nx4s	78	4	generally	generally	RB
cord-310192-8x37nx4s	78	5	restricted	restrict	VBN
cord-310192-8x37nx4s	78	6	the	the	DT
cord-310192-8x37nx4s	78	7	size	size	NN
cord-310192-8x37nx4s	78	8	of	of	IN
cord-310192-8x37nx4s	78	9	RNA	RNA	NNP
cord-310192-8x37nx4s	78	10	that	that	WDT
cord-310192-8x37nx4s	78	11	can	can	MD
cord-310192-8x37nx4s	78	12	be	be	VB
cord-310192-8x37nx4s	78	13	studied	study	VBN
cord-310192-8x37nx4s	78	14	by	by	IN
cord-310192-8x37nx4s	78	15	NMR	NMR	NNP
cord-310192-8x37nx4s	78	16	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	78	17	.	.	.
cord-310192-8x37nx4s	79	1	Of	of	IN
cord-310192-8x37nx4s	79	2	the	the	DT
cord-310192-8x37nx4s	79	3	RNA	RNA	NNP
cord-310192-8x37nx4s	79	4	structures	structure	NNS
cord-310192-8x37nx4s	79	5	determined	determine	VBN
cord-310192-8x37nx4s	79	6	by	by	IN
cord-310192-8x37nx4s	79	7	NMR	NMR	NNP
cord-310192-8x37nx4s	79	8	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	79	9	,	,	,
cord-310192-8x37nx4s	79	10	the	the	DT
cord-310192-8x37nx4s	79	11	average	average	JJ
cord-310192-8x37nx4s	79	12	size	size	NN
cord-310192-8x37nx4s	79	13	is	be	VBZ
cord-310192-8x37nx4s	79	14	30	30	CD
cord-310192-8x37nx4s	79	15	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	79	16	with	with	IN
cord-310192-8x37nx4s	79	17	only	only	RB
cord-310192-8x37nx4s	79	18	six	six	CD
cord-310192-8x37nx4s	79	19	structures	structure	NNS
cord-310192-8x37nx4s	79	20	of	of	IN
cord-310192-8x37nx4s	79	21	RNA	RNA	NNP
cord-310192-8x37nx4s	79	22	larger	large	JJR
cord-310192-8x37nx4s	79	23	than	than	IN
cord-310192-8x37nx4s	79	24	100	100	CD
cord-310192-8x37nx4s	79	25	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	79	26	(	(	-LRB-
cord-310192-8x37nx4s	79	27	nt	nt	RB
cord-310192-8x37nx4s	79	28	)	)	-RRB-
cord-310192-8x37nx4s	80	1	(	(	-LRB-
cord-310192-8x37nx4s	80	2	Figure	figure	NN
cord-310192-8x37nx4s	80	3	1	1	CD
cord-310192-8x37nx4s	80	4	)	)	-RRB-
cord-310192-8x37nx4s	80	5	(	(	-LRB-
cord-310192-8x37nx4s	80	6	Berman	Berman	NNP
cord-310192-8x37nx4s	80	7	et	et	NNP
cord-310192-8x37nx4s	80	8	al	al	NNP
cord-310192-8x37nx4s	80	9	.	.	NNP
cord-310192-8x37nx4s	80	10	,	,	,
cord-310192-8x37nx4s	80	11	2000	2000	CD
cord-310192-8x37nx4s	80	12	;	;	:
cord-310192-8x37nx4s	80	13	http://www.rcsb.org	http://www.rcsb.org	NFP
cord-310192-8x37nx4s	80	14	)	)	-RRB-
cord-310192-8x37nx4s	80	15	.	.	.
cord-310192-8x37nx4s	81	1	While	while	IN
cord-310192-8x37nx4s	81	2	solution	solution	NN
cord-310192-8x37nx4s	81	3	NMR	nmr	NN
cord-310192-8x37nx4s	81	4	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	81	5	has	have	VBZ
cord-310192-8x37nx4s	81	6	a	a	DT
cord-310192-8x37nx4s	81	7	number	number	NN
cord-310192-8x37nx4s	81	8	of	of	IN
cord-310192-8x37nx4s	81	9	technical	technical	JJ
cord-310192-8x37nx4s	81	10	challenges	challenge	NNS
cord-310192-8x37nx4s	81	11	,	,	,
cord-310192-8x37nx4s	81	12	it	-PRON-	PRP
cord-310192-8x37nx4s	81	13	also	also	RB
cord-310192-8x37nx4s	81	14	has	have	VBZ
cord-310192-8x37nx4s	81	15	some	some	DT
cord-310192-8x37nx4s	81	16	distinct	distinct	JJ
cord-310192-8x37nx4s	81	17	advantages	advantage	NNS
cord-310192-8x37nx4s	81	18	.	.	.
cord-310192-8x37nx4s	82	1	(	(	-LRB-
cord-310192-8x37nx4s	82	2	a	a	LS
cord-310192-8x37nx4s	82	3	)	)	-RRB-
cord-310192-8x37nx4s	82	4	Tertiary	tertiary	JJ
cord-310192-8x37nx4s	82	5	structure	structure	NN
cord-310192-8x37nx4s	82	6	information	information	NN
cord-310192-8x37nx4s	82	7	.	.	.
cord-310192-8x37nx4s	83	1	While	while	IN
cord-310192-8x37nx4s	83	2	secondary	secondary	JJ
cord-310192-8x37nx4s	83	3	structure	structure	NN
cord-310192-8x37nx4s	83	4	is	be	VBZ
cord-310192-8x37nx4s	83	5	importantly	importantly	RB
cord-310192-8x37nx4s	83	6	represented	represent	VBN
cord-310192-8x37nx4s	83	7	in	in	IN
cord-310192-8x37nx4s	83	8	the	the	DT
cord-310192-8x37nx4s	83	9	three	three	CD
cord-310192-8x37nx4s	83	10	-	-	HYPH
cord-310192-8x37nx4s	83	11	dimensional	dimensional	JJ
cord-310192-8x37nx4s	83	12	structure	structure	NN
cord-310192-8x37nx4s	83	13	of	of	IN
cord-310192-8x37nx4s	83	14	RNAs	rna	NNS
cord-310192-8x37nx4s	83	15	,	,	,
cord-310192-8x37nx4s	83	16	the	the	DT
cord-310192-8x37nx4s	83	17	tertiary	tertiary	JJ
cord-310192-8x37nx4s	83	18	structure	structure	NN
cord-310192-8x37nx4s	83	19	provides	provide	VBZ
cord-310192-8x37nx4s	83	20	key	key	JJ
cord-310192-8x37nx4s	83	21	insights	insight	NNS
cord-310192-8x37nx4s	83	22	into	into	IN
cord-310192-8x37nx4s	83	23	the	the	DT
cord-310192-8x37nx4s	83	24	function	function	NN
cord-310192-8x37nx4s	83	25	of	of	IN
cord-310192-8x37nx4s	83	26	the	the	DT
cord-310192-8x37nx4s	83	27	RNA	RNA	NNP
cord-310192-8x37nx4s	83	28	.	.	.
cord-310192-8x37nx4s	84	1	(	(	-LRB-
cord-310192-8x37nx4s	84	2	b	b	LS
cord-310192-8x37nx4s	84	3	)	)	-RRB-
cord-310192-8x37nx4s	84	4	Study	study	VB
cord-310192-8x37nx4s	84	5	the	the	DT
cord-310192-8x37nx4s	84	6	native	native	JJ
cord-310192-8x37nx4s	84	7	conformation	conformation	NN
cord-310192-8x37nx4s	84	8	of	of	IN
cord-310192-8x37nx4s	84	9	an	an	DT
cord-310192-8x37nx4s	84	10	RNA	RNA	NNP
cord-310192-8x37nx4s	84	11	.	.	.
cord-310192-8x37nx4s	85	1	Because	because	IN
cord-310192-8x37nx4s	85	2	NMR	NMR	NNP
cord-310192-8x37nx4s	85	3	is	be	VBZ
cord-310192-8x37nx4s	85	4	not	not	RB
cord-310192-8x37nx4s	85	5	predicated	predicate	VBN
cord-310192-8x37nx4s	85	6	on	on	IN
cord-310192-8x37nx4s	85	7	growing	grow	VBG
cord-310192-8x37nx4s	85	8	crystals	crystal	NNS
cord-310192-8x37nx4s	85	9	of	of	IN
cord-310192-8x37nx4s	85	10	the	the	DT
cord-310192-8x37nx4s	85	11	sample	sample	NN
cord-310192-8x37nx4s	85	12	,	,	,
cord-310192-8x37nx4s	85	13	there	there	EX
cord-310192-8x37nx4s	85	14	are	be	VBP
cord-310192-8x37nx4s	85	15	no	no	DT
cord-310192-8x37nx4s	85	16	concerns	concern	NNS
cord-310192-8x37nx4s	85	17	that	that	IN
cord-310192-8x37nx4s	85	18	the	the	DT
cord-310192-8x37nx4s	85	19	structure	structure	NN
cord-310192-8x37nx4s	85	20	might	may	MD
cord-310192-8x37nx4s	85	21	be	be	VB
cord-310192-8x37nx4s	85	22	affected	affect	VBN
cord-310192-8x37nx4s	85	23	by	by	IN
cord-310192-8x37nx4s	85	24	crystal	crystal	NN
cord-310192-8x37nx4s	85	25	F	F	NNP
cord-310192-8x37nx4s	86	1	I	-PRON-	PRP
cord-310192-8x37nx4s	86	2	G	g	NN
cord-310192-8x37nx4s	86	3	U	u	NN
cord-310192-8x37nx4s	86	4	R	r	NN
cord-310192-8x37nx4s	86	5	E	e	NN
cord-310192-8x37nx4s	86	6	1	1	CD
cord-310192-8x37nx4s	86	7	Histogram	Histogram	NNP
cord-310192-8x37nx4s	86	8	of	of	IN
cord-310192-8x37nx4s	86	9	RNA	RNA	NNP
cord-310192-8x37nx4s	86	10	structures	structure	NNS
cord-310192-8x37nx4s	86	11	that	that	WDT
cord-310192-8x37nx4s	86	12	were	be	VBD
cord-310192-8x37nx4s	86	13	determined	determine	VBN
cord-310192-8x37nx4s	86	14	using	use	VBG
cord-310192-8x37nx4s	86	15	nuclear	nuclear	JJ
cord-310192-8x37nx4s	86	16	magnetic	magnetic	JJ
cord-310192-8x37nx4s	86	17	resonance	resonance	NN
cord-310192-8x37nx4s	86	18	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	86	19	.	.	.
cord-310192-8x37nx4s	87	1	The	the	DT
cord-310192-8x37nx4s	87	2	size	size	NN
cord-310192-8x37nx4s	87	3	of	of	IN
cord-310192-8x37nx4s	87	4	the	the	DT
cord-310192-8x37nx4s	87	5	RNA	RNA	NNP
cord-310192-8x37nx4s	87	6	molecule	molecule	NN
cord-310192-8x37nx4s	87	7	(	(	-LRB-
cord-310192-8x37nx4s	87	8	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	87	9	,	,	,
cord-310192-8x37nx4s	87	10	nt	nt	RB
cord-310192-8x37nx4s	87	11	)	)	-RRB-
cord-310192-8x37nx4s	87	12	is	be	VBZ
cord-310192-8x37nx4s	87	13	correlated	correlate	VBN
cord-310192-8x37nx4s	87	14	with	with	IN
cord-310192-8x37nx4s	87	15	the	the	DT
cord-310192-8x37nx4s	87	16	number	number	NN
cord-310192-8x37nx4s	87	17	of	of	IN
cord-310192-8x37nx4s	87	18	structures	structure	NNS
cord-310192-8x37nx4s	87	19	reported	report	VBN
cord-310192-8x37nx4s	87	20	in	in	IN
cord-310192-8x37nx4s	87	21	the	the	DT
cord-310192-8x37nx4s	87	22	Protein	Protein	NNP
cord-310192-8x37nx4s	87	23	Data	Data	NNP
cord-310192-8x37nx4s	87	24	Bank	Bank	NNP
cord-310192-8x37nx4s	87	25	(	(	-LRB-
cord-310192-8x37nx4s	87	26	rcsb.org	rcsb.org	NNP
cord-310192-8x37nx4s	87	27	,	,	,
cord-310192-8x37nx4s	87	28	June	June	NNP
cord-310192-8x37nx4s	87	29	2018	2018	CD
cord-310192-8x37nx4s	87	30	)	)	-RRB-
cord-310192-8x37nx4s	87	31	packing	packing	NN
cord-310192-8x37nx4s	87	32	or	or	CC
cord-310192-8x37nx4s	87	33	the	the	DT
cord-310192-8x37nx4s	87	34	conditions	condition	NNS
cord-310192-8x37nx4s	87	35	under	under	IN
cord-310192-8x37nx4s	87	36	which	which	WDT
cord-310192-8x37nx4s	87	37	crystals	crystal	NNS
cord-310192-8x37nx4s	87	38	can	can	MD
cord-310192-8x37nx4s	87	39	be	be	VB
cord-310192-8x37nx4s	87	40	grown	grow	VBN
cord-310192-8x37nx4s	87	41	.	.	.
cord-310192-8x37nx4s	88	1	(	(	-LRB-
cord-310192-8x37nx4s	88	2	c	c	NN
cord-310192-8x37nx4s	88	3	)	)	-RRB-
cord-310192-8x37nx4s	88	4	Access	access	NN
cord-310192-8x37nx4s	88	5	to	to	IN
cord-310192-8x37nx4s	88	6	information	information	NN
cord-310192-8x37nx4s	88	7	about	about	IN
cord-310192-8x37nx4s	88	8	dynamics	dynamic	NNS
cord-310192-8x37nx4s	88	9	.	.	.
cord-310192-8x37nx4s	89	1	While	while	IN
cord-310192-8x37nx4s	89	2	a	a	DT
cord-310192-8x37nx4s	89	3	number	number	NN
cord-310192-8x37nx4s	89	4	of	of	IN
cord-310192-8x37nx4s	89	5	biophysical	biophysical	JJ
cord-310192-8x37nx4s	89	6	techniques	technique	NNS
cord-310192-8x37nx4s	89	7	can	can	MD
cord-310192-8x37nx4s	89	8	be	be	VB
cord-310192-8x37nx4s	89	9	applied	apply	VBN
cord-310192-8x37nx4s	89	10	to	to	TO
cord-310192-8x37nx4s	89	11	study	study	VB
cord-310192-8x37nx4s	89	12	dynamic	dynamic	JJ
cord-310192-8x37nx4s	89	13	processes	process	NNS
cord-310192-8x37nx4s	89	14	in	in	IN
cord-310192-8x37nx4s	89	15	RNA	RNA	NNP
cord-310192-8x37nx4s	89	16	molecules	molecule	NNS
cord-310192-8x37nx4s	89	17	(	(	-LRB-
cord-310192-8x37nx4s	90	1	Hao	Hao	NNP
cord-310192-8x37nx4s	90	2	et	et	NNP
cord-310192-8x37nx4s	90	3	al	al	NNP
cord-310192-8x37nx4s	90	4	.	.	.
cord-310192-8x37nx4s	91	1	,	,	,
cord-310192-8x37nx4s	91	2	2018	2018	CD
cord-310192-8x37nx4s	91	3	;	;	:
cord-310192-8x37nx4s	91	4	P.	P.	NNP
cord-310192-8x37nx4s	91	5	Nguyen	Nguyen	NNP
cord-310192-8x37nx4s	91	6	&	&	CC
cord-310192-8x37nx4s	91	7	Qin	Qin	NNP
cord-310192-8x37nx4s	91	8	,	,	,
cord-310192-8x37nx4s	91	9	2012	2012	CD
cord-310192-8x37nx4s	91	10	;	;	:
cord-310192-8x37nx4s	91	11	Panja	Panja	NNP
cord-310192-8x37nx4s	91	12	,	,	,
cord-310192-8x37nx4s	91	13	Hua	Hua	NNP
cord-310192-8x37nx4s	91	14	,	,	,
cord-310192-8x37nx4s	91	15	Zegarra	Zegarra	NNP
cord-310192-8x37nx4s	91	16	,	,	,
cord-310192-8x37nx4s	91	17	Ha	ha	UH
cord-310192-8x37nx4s	91	18	,	,	,
cord-310192-8x37nx4s	91	19	&	&	CC
cord-310192-8x37nx4s	91	20	Woodson	Woodson	NNP
cord-310192-8x37nx4s	91	21	,	,	,
cord-310192-8x37nx4s	91	22	2017	2017	CD
cord-310192-8x37nx4s	91	23	;	;	:
cord-310192-8x37nx4s	91	24	Ritchie	Ritchie	NNP
cord-310192-8x37nx4s	91	25	&	&	CC
cord-310192-8x37nx4s	91	26	Woodside	Woodside	NNP
cord-310192-8x37nx4s	91	27	,	,	,
cord-310192-8x37nx4s	91	28	2015	2015	CD
cord-310192-8x37nx4s	91	29	)	)	-RRB-
cord-310192-8x37nx4s	91	30	,	,	,
cord-310192-8x37nx4s	91	31	NMR	NMR	NNP
cord-310192-8x37nx4s	91	32	is	be	VBZ
cord-310192-8x37nx4s	91	33	uniquely	uniquely	RB
cord-310192-8x37nx4s	91	34	poised	poise	VBN
cord-310192-8x37nx4s	91	35	to	to	TO
cord-310192-8x37nx4s	91	36	study	study	VB
cord-310192-8x37nx4s	91	37	the	the	DT
cord-310192-8x37nx4s	91	38	dynamics	dynamic	NNS
cord-310192-8x37nx4s	91	39	of	of	IN
cord-310192-8x37nx4s	91	40	biomolecules	biomolecule	NNS
cord-310192-8x37nx4s	91	41	at	at	IN
cord-310192-8x37nx4s	91	42	atomic	atomic	JJ
cord-310192-8x37nx4s	91	43	resolution	resolution	NN
cord-310192-8x37nx4s	91	44	and	and	CC
cord-310192-8x37nx4s	91	45	over	over	IN
cord-310192-8x37nx4s	91	46	a	a	DT
cord-310192-8x37nx4s	91	47	wide	wide	JJ
cord-310192-8x37nx4s	91	48	range	range	NN
cord-310192-8x37nx4s	91	49	of	of	IN
cord-310192-8x37nx4s	91	50	timescales	timescale	NNS
cord-310192-8x37nx4s	91	51	(	(	-LRB-
cord-310192-8x37nx4s	91	52	Al	Al	NNP
cord-310192-8x37nx4s	91	53	-	-	HYPH
cord-310192-8x37nx4s	91	54	Hashimi	Hashimi	NNP
cord-310192-8x37nx4s	91	55	&	&	CC
cord-310192-8x37nx4s	91	56	Walter	Walter	NNP
cord-310192-8x37nx4s	91	57	,	,	,
cord-310192-8x37nx4s	91	58	2008	2008	CD
cord-310192-8x37nx4s	91	59	;	;	:
cord-310192-8x37nx4s	91	60	Marion	Marion	NNP
cord-310192-8x37nx4s	91	61	,	,	,
cord-310192-8x37nx4s	91	62	2013	2013	CD
cord-310192-8x37nx4s	91	63	)	)	-RRB-
cord-310192-8x37nx4s	91	64	.	.	.
cord-310192-8x37nx4s	92	1	Structure	structure	NN
cord-310192-8x37nx4s	92	2	determination	determination	NN
cord-310192-8x37nx4s	92	3	by	by	IN
cord-310192-8x37nx4s	92	4	NMR	NMR	NNP
cord-310192-8x37nx4s	92	5	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	92	6	is	be	VBZ
cord-310192-8x37nx4s	92	7	first	first	JJ
cord-310192-8x37nx4s	92	8	and	and	CC
cord-310192-8x37nx4s	92	9	foremost	foremost	RB
cord-310192-8x37nx4s	92	10	predicated	predicated	JJ
cord-310192-8x37nx4s	92	11	on	on	IN
cord-310192-8x37nx4s	92	12	having	have	VBG
cord-310192-8x37nx4s	92	13	assignments	assignment	NNS
cord-310192-8x37nx4s	92	14	for	for	IN
cord-310192-8x37nx4s	92	15	all	all	DT
cord-310192-8x37nx4s	92	16	(	(	-LRB-
cord-310192-8x37nx4s	92	17	or	or	CC
cord-310192-8x37nx4s	92	18	most	most	JJS
cord-310192-8x37nx4s	92	19	)	)	-RRB-
cord-310192-8x37nx4s	92	20	atoms	atom	NNS
cord-310192-8x37nx4s	92	21	within	within	IN
cord-310192-8x37nx4s	92	22	the	the	DT
cord-310192-8x37nx4s	92	23	molecule	molecule	NN
cord-310192-8x37nx4s	92	24	.	.	.
cord-310192-8x37nx4s	93	1	Chemical	chemical	JJ
cord-310192-8x37nx4s	93	2	shift	shift	NN
cord-310192-8x37nx4s	93	3	assignments	assignment	NNS
cord-310192-8x37nx4s	93	4	can	can	MD
cord-310192-8x37nx4s	93	5	be	be	VB
cord-310192-8x37nx4s	93	6	made	make	VBN
cord-310192-8x37nx4s	93	7	via	via	IN
cord-310192-8x37nx4s	93	8	analysis	analysis	NN
cord-310192-8x37nx4s	93	9	of	of	IN
cord-310192-8x37nx4s	93	10	a	a	DT
cord-310192-8x37nx4s	93	11	variety	variety	NN
cord-310192-8x37nx4s	93	12	of	of	IN
cord-310192-8x37nx4s	93	13	data	datum	NNS
cord-310192-8x37nx4s	93	14	and	and	CC
cord-310192-8x37nx4s	93	15	are	be	VBP
cord-310192-8x37nx4s	93	16	useful	useful	JJ
cord-310192-8x37nx4s	93	17	in	in	IN
cord-310192-8x37nx4s	93	18	the	the	DT
cord-310192-8x37nx4s	93	19	analysis	analysis	NN
cord-310192-8x37nx4s	93	20	of	of	IN
cord-310192-8x37nx4s	93	21	nuclear	nuclear	JJ
cord-310192-8x37nx4s	93	22	Overhauser	Overhauser	NNP
cord-310192-8x37nx4s	93	23	effect	effect	NN
cord-310192-8x37nx4s	93	24	(	(	-LRB-
cord-310192-8x37nx4s	93	25	NOE	NOE	NNP
cord-310192-8x37nx4s	93	26	)	)	-RRB-
cord-310192-8x37nx4s	93	27	distance	distance	NN
cord-310192-8x37nx4s	93	28	restraints	restraint	NNS
cord-310192-8x37nx4s	93	29	,	,	,
cord-310192-8x37nx4s	93	30	among	among	IN
cord-310192-8x37nx4s	93	31	others	other	NNS
cord-310192-8x37nx4s	93	32	.	.	.
cord-310192-8x37nx4s	94	1	The	the	DT
cord-310192-8x37nx4s	94	2	experimental	experimental	JJ
cord-310192-8x37nx4s	94	3	restraints	restraint	NNS
cord-310192-8x37nx4s	94	4	can	can	MD
cord-310192-8x37nx4s	94	5	then	then	RB
cord-310192-8x37nx4s	94	6	be	be	VB
cord-310192-8x37nx4s	94	7	combined	combine	VBN
cord-310192-8x37nx4s	94	8	with	with	IN
cord-310192-8x37nx4s	94	9	empirical	empirical	JJ
cord-310192-8x37nx4s	94	10	restraints	restraint	NNS
cord-310192-8x37nx4s	94	11	to	to	TO
cord-310192-8x37nx4s	94	12	generate	generate	VB
cord-310192-8x37nx4s	94	13	initial	initial	JJ
cord-310192-8x37nx4s	94	14	geometry	geometry	NN
cord-310192-8x37nx4s	94	15	-	-	HYPH
cord-310192-8x37nx4s	94	16	based	base	VBN
cord-310192-8x37nx4s	94	17	structural	structural	JJ
cord-310192-8x37nx4s	94	18	models	model	NNS
cord-310192-8x37nx4s	94	19	.	.	.
cord-310192-8x37nx4s	95	1	These	these	DT
cord-310192-8x37nx4s	95	2	initial	initial	JJ
cord-310192-8x37nx4s	95	3	structural	structural	JJ
cord-310192-8x37nx4s	95	4	models	model	NNS
cord-310192-8x37nx4s	95	5	can	can	MD
cord-310192-8x37nx4s	95	6	then	then	RB
cord-310192-8x37nx4s	95	7	be	be	VB
cord-310192-8x37nx4s	95	8	refined	refine	VBN
cord-310192-8x37nx4s	95	9	using	use	VBG
cord-310192-8x37nx4s	95	10	a	a	DT
cord-310192-8x37nx4s	95	11	simulated	simulate	VBN
cord-310192-8x37nx4s	95	12	annealing	anneal	VBG
cord-310192-8x37nx4s	95	13	strategy	strategy	NN
cord-310192-8x37nx4s	95	14	to	to	TO
cord-310192-8x37nx4s	95	15	generate	generate	VB
cord-310192-8x37nx4s	95	16	an	an	DT
cord-310192-8x37nx4s	95	17	ensemble	ensemble	NN
cord-310192-8x37nx4s	95	18	of	of	IN
cord-310192-8x37nx4s	95	19	20	20	CD
cord-310192-8x37nx4s	95	20	lowest	low	JJS
cord-310192-8x37nx4s	95	21	energy	energy	NN
cord-310192-8x37nx4s	95	22	conformers	conformer	NNS
cord-310192-8x37nx4s	95	23	.	.	.
cord-310192-8x37nx4s	96	1	In	in	IN
cord-310192-8x37nx4s	96	2	order	order	NN
cord-310192-8x37nx4s	96	3	to	to	TO
cord-310192-8x37nx4s	96	4	simplify	simplify	VB
cord-310192-8x37nx4s	96	5	,	,	,
cord-310192-8x37nx4s	96	6	or	or	CC
cord-310192-8x37nx4s	96	7	in	in	IN
cord-310192-8x37nx4s	96	8	some	some	DT
cord-310192-8x37nx4s	96	9	cases	case	NNS
cord-310192-8x37nx4s	96	10	make	make	VBP
cord-310192-8x37nx4s	96	11	possible	possible	JJ
cord-310192-8x37nx4s	96	12	,	,	,
cord-310192-8x37nx4s	96	13	the	the	DT
cord-310192-8x37nx4s	96	14	analysis	analysis	NN
cord-310192-8x37nx4s	96	15	and	and	CC
cord-310192-8x37nx4s	96	16	collection	collection	NN
cord-310192-8x37nx4s	96	17	of	of	IN
cord-310192-8x37nx4s	96	18	data	datum	NNS
cord-310192-8x37nx4s	96	19	for	for	IN
cord-310192-8x37nx4s	96	20	very	very	RB
cord-310192-8x37nx4s	96	21	large	large	JJ
cord-310192-8x37nx4s	96	22	RNAs	rna	NNS
cord-310192-8x37nx4s	96	23	,	,	,
cord-310192-8x37nx4s	96	24	a	a	DT
cord-310192-8x37nx4s	96	25	number	number	NN
cord-310192-8x37nx4s	96	26	of	of	IN
cord-310192-8x37nx4s	96	27	both	both	DT
cord-310192-8x37nx4s	96	28	methodological	methodological	JJ
cord-310192-8x37nx4s	96	29	and	and	CC
cord-310192-8x37nx4s	96	30	technical	technical	JJ
cord-310192-8x37nx4s	96	31	improvements	improvement	NNS
cord-310192-8x37nx4s	96	32	have	have	VBP
cord-310192-8x37nx4s	96	33	recently	recently	RB
cord-310192-8x37nx4s	96	34	been	be	VBN
cord-310192-8x37nx4s	96	35	developed	develop	VBN
cord-310192-8x37nx4s	96	36	.	.	.
cord-310192-8x37nx4s	97	1	Some	some	DT
cord-310192-8x37nx4s	97	2	of	of	IN
cord-310192-8x37nx4s	97	3	the	the	DT
cord-310192-8x37nx4s	97	4	key	key	JJ
cord-310192-8x37nx4s	97	5	contributions	contribution	NNS
cord-310192-8x37nx4s	97	6	are	be	VBP
cord-310192-8x37nx4s	97	7	highlighted	highlight	VBN
cord-310192-8x37nx4s	97	8	below	below	RB
cord-310192-8x37nx4s	97	9	.	.	.
cord-310192-8x37nx4s	98	1	Because	because	IN
cord-310192-8x37nx4s	98	2	of	of	IN
cord-310192-8x37nx4s	98	3	the	the	DT
cord-310192-8x37nx4s	98	4	limited	limited	JJ
cord-310192-8x37nx4s	98	5	chemical	chemical	NN
cord-310192-8x37nx4s	98	6	shift	shift	NN
cord-310192-8x37nx4s	98	7	dispersion	dispersion	NN
cord-310192-8x37nx4s	98	8	that	that	WDT
cord-310192-8x37nx4s	98	9	RNAs	rna	NNS
cord-310192-8x37nx4s	98	10	exhibit	exhibit	VBP
cord-310192-8x37nx4s	98	11	,	,	,
cord-310192-8x37nx4s	98	12	NMR	NMR	NNP
cord-310192-8x37nx4s	98	13	spectra	spectrum	NNS
cord-310192-8x37nx4s	98	14	of	of	IN
cord-310192-8x37nx4s	98	15	unlabeled	unlabeled	JJ
cord-310192-8x37nx4s	98	16	large	large	JJ
cord-310192-8x37nx4s	98	17	RNAs	rna	NNS
cord-310192-8x37nx4s	98	18	are	be	VBP
cord-310192-8x37nx4s	98	19	extremely	extremely	RB
cord-310192-8x37nx4s	98	20	crowded	crowded	JJ
cord-310192-8x37nx4s	98	21	,	,	,
cord-310192-8x37nx4s	98	22	prohibiting	prohibit	VBG
cord-310192-8x37nx4s	98	23	unambiguous	unambiguous	JJ
cord-310192-8x37nx4s	98	24	resonance	resonance	NN
cord-310192-8x37nx4s	98	25	assignment	assignment	NN
cord-310192-8x37nx4s	98	26	(	(	-LRB-
cord-310192-8x37nx4s	98	27	Figure	figure	NN
cord-310192-8x37nx4s	98	28	2a	2a	CD
cord-310192-8x37nx4s	98	29	)	)	-RRB-
cord-310192-8x37nx4s	98	30	.	.	.
cord-310192-8x37nx4s	99	1	There	there	EX
cord-310192-8x37nx4s	99	2	are	be	VBP
cord-310192-8x37nx4s	99	3	a	a	DT
cord-310192-8x37nx4s	99	4	number	number	NN
cord-310192-8x37nx4s	99	5	of	of	IN
cord-310192-8x37nx4s	99	6	ways	way	NNS
cord-310192-8x37nx4s	99	7	to	to	TO
cord-310192-8x37nx4s	99	8	"	"	``
cord-310192-8x37nx4s	99	9	edit	edit	VB
cord-310192-8x37nx4s	99	10	"	"	''
cord-310192-8x37nx4s	99	11	a	a	DT
cord-310192-8x37nx4s	99	12	spectrum	spectrum	NN
cord-310192-8x37nx4s	99	13	,	,	,
cord-310192-8x37nx4s	99	14	separating	separate	VBG
cord-310192-8x37nx4s	99	15	chemical	chemical	NN
cord-310192-8x37nx4s	99	16	shifts	shift	NNS
cord-310192-8x37nx4s	99	17	by	by	IN
cord-310192-8x37nx4s	99	18	a	a	DT
cord-310192-8x37nx4s	99	19	second	second	JJ
cord-310192-8x37nx4s	99	20	NMR	nmr	NN
cord-310192-8x37nx4s	99	21	-	-	HYPH
cord-310192-8x37nx4s	99	22	active	active	JJ
cord-310192-8x37nx4s	99	23	nucleus	nucleus	NN
cord-310192-8x37nx4s	99	24	(	(	-LRB-
cord-310192-8x37nx4s	99	25	typically	typically	RB
cord-310192-8x37nx4s	99	26	15	15	CD
cord-310192-8x37nx4s	99	27	N	n	CD
cord-310192-8x37nx4s	99	28	or	or	CC
cord-310192-8x37nx4s	99	29	13	13	CD
cord-310192-8x37nx4s	99	30	C	C	NNP
cord-310192-8x37nx4s	99	31	)	)	-RRB-
cord-310192-8x37nx4s	99	32	.	.	.
cord-310192-8x37nx4s	100	1	However	however	RB
cord-310192-8x37nx4s	100	2	,	,	,
cord-310192-8x37nx4s	100	3	the	the	DT
cord-310192-8x37nx4s	100	4	large	large	JJ
cord-310192-8x37nx4s	100	5	13	13	CD
cord-310192-8x37nx4s	100	6	C-1	C-1	NNP
cord-310192-8x37nx4s	100	7	H	h	NN
cord-310192-8x37nx4s	100	8	dipolar	dipolar	NN
cord-310192-8x37nx4s	100	9	coupling	coupling	NN
cord-310192-8x37nx4s	100	10	has	have	VBZ
cord-310192-8x37nx4s	100	11	a	a	DT
cord-310192-8x37nx4s	100	12	significant	significant	JJ
cord-310192-8x37nx4s	100	13	effect	effect	NN
cord-310192-8x37nx4s	100	14	on	on	IN
cord-310192-8x37nx4s	100	15	T2	T2	NNP
cord-310192-8x37nx4s	100	16	relaxation	relaxation	NN
cord-310192-8x37nx4s	100	17	mechanisms	mechanism	NNS
cord-310192-8x37nx4s	100	18	leading	lead	VBG
cord-310192-8x37nx4s	100	19	to	to	IN
cord-310192-8x37nx4s	100	20	broad	broad	JJ
cord-310192-8x37nx4s	100	21	line	line	NN
cord-310192-8x37nx4s	100	22	widths	width	NNS
cord-310192-8x37nx4s	100	23	thereby	thereby	RB
cord-310192-8x37nx4s	100	24	limiting	limit	VBG
cord-310192-8x37nx4s	100	25	the	the	DT
cord-310192-8x37nx4s	100	26	sensitivity	sensitivity	NN
cord-310192-8x37nx4s	100	27	of	of	IN
cord-310192-8x37nx4s	100	28	heteronuclear	heteronuclear	NN
cord-310192-8x37nx4s	100	29	correlation	correlation	NN
cord-310192-8x37nx4s	100	30	experiments	experiment	NNS
cord-310192-8x37nx4s	100	31	,	,	,
cord-310192-8x37nx4s	100	32	particularly	particularly	RB
cord-310192-8x37nx4s	100	33	for	for	IN
cord-310192-8x37nx4s	100	34	large	large	JJ
cord-310192-8x37nx4s	100	35	RNAs	rna	NNS
cord-310192-8x37nx4s	100	36	that	that	WDT
cord-310192-8x37nx4s	100	37	have	have	VBP
cord-310192-8x37nx4s	100	38	large	large	JJ
cord-310192-8x37nx4s	100	39	rotational	rotational	JJ
cord-310192-8x37nx4s	100	40	correlation	correlation	NN
cord-310192-8x37nx4s	100	41	times	time	NNS
cord-310192-8x37nx4s	100	42	(	(	-LRB-
cord-310192-8x37nx4s	100	43	A.	A.	NNP
cord-310192-8x37nx4s	100	44	L.	L.	NNP
cord-310192-8x37nx4s	100	45	Hansen	Hansen	NNP
cord-310192-8x37nx4s	100	46	&	&	CC
cord-310192-8x37nx4s	100	47	Al	Al	NNP
cord-310192-8x37nx4s	100	48	-	-	HYPH
cord-310192-8x37nx4s	100	49	Hashimi	Hashimi	NNP
cord-310192-8x37nx4s	100	50	,	,	,
cord-310192-8x37nx4s	100	51	2006	2006	CD
cord-310192-8x37nx4s	100	52	;	;	:
cord-310192-8x37nx4s	100	53	Lu	Lu	NNP
cord-310192-8x37nx4s	100	54	,	,	,
cord-310192-8x37nx4s	100	55	Miyazaki	Miyazaki	NNP
cord-310192-8x37nx4s	100	56	,	,	,
cord-310192-8x37nx4s	100	57	&	&	CC
cord-310192-8x37nx4s	100	58	Summers	Summers	NNPS
cord-310192-8x37nx4s	100	59	,	,	,
cord-310192-8x37nx4s	100	60	2010	2010	CD
cord-310192-8x37nx4s	100	61	;	;	:
cord-310192-8x37nx4s	100	62	Tolbert	Tolbert	NNP
cord-310192-8x37nx4s	100	63	et	et	NNP
cord-310192-8x37nx4s	100	64	al	al	NNP
cord-310192-8x37nx4s	100	65	.	.	NNP
cord-310192-8x37nx4s	100	66	,	,	,
cord-310192-8x37nx4s	100	67	2010	2010	CD
cord-310192-8x37nx4s	100	68	)	)	-RRB-
cord-310192-8x37nx4s	100	69	.	.	.
cord-310192-8x37nx4s	101	1	One	one	CD
cord-310192-8x37nx4s	101	2	attractive	attractive	JJ
cord-310192-8x37nx4s	101	3	alternative	alternative	NN
cord-310192-8x37nx4s	101	4	to	to	IN
cord-310192-8x37nx4s	101	5	the	the	DT
cord-310192-8x37nx4s	101	6	traditional	traditional	JJ
cord-310192-8x37nx4s	101	7	heteronuclear	heteronuclear	NN
cord-310192-8x37nx4s	101	8	experiments	experiment	NNS
cord-310192-8x37nx4s	101	9	is	be	VBZ
cord-310192-8x37nx4s	101	10	to	to	TO
cord-310192-8x37nx4s	101	11	"	"	``
cord-310192-8x37nx4s	101	12	edit	edit	VB
cord-310192-8x37nx4s	101	13	"	"	''
cord-310192-8x37nx4s	101	14	a	a	DT
cord-310192-8x37nx4s	101	15	spectrum	spectrum	NN
cord-310192-8x37nx4s	101	16	by	by	IN
cord-310192-8x37nx4s	101	17	the	the	DT
cord-310192-8x37nx4s	101	18	nucleotide	nucleotide	JJ
cord-310192-8x37nx4s	101	19	-	-	HYPH
cord-310192-8x37nx4s	101	20	specific	specific	JJ
cord-310192-8x37nx4s	101	21	incorporation	incorporation	NN
cord-310192-8x37nx4s	101	22	of	of	IN
cord-310192-8x37nx4s	101	23	deuterium	deuterium	NN
cord-310192-8x37nx4s	101	24	atoms	atom	NNS
cord-310192-8x37nx4s	101	25	throughout	throughout	IN
cord-310192-8x37nx4s	101	26	the	the	DT
cord-310192-8x37nx4s	101	27	RNA	RNA	NNP
cord-310192-8x37nx4s	101	28	.	.	.
cord-310192-8x37nx4s	102	1	Using	use	VBG
cord-310192-8x37nx4s	102	2	this	this	DT
cord-310192-8x37nx4s	102	3	approach	approach	NN
cord-310192-8x37nx4s	102	4	,	,	,
cord-310192-8x37nx4s	102	5	protons	proton	NNS
cord-310192-8x37nx4s	102	6	are	be	VBP
cord-310192-8x37nx4s	102	7	replaced	replace	VBN
cord-310192-8x37nx4s	102	8	with	with	IN
cord-310192-8x37nx4s	102	9	deuterium	deuterium	NN
cord-310192-8x37nx4s	102	10	and	and	CC
cord-310192-8x37nx4s	102	11	because	because	IN
cord-310192-8x37nx4s	102	12	deuterium	deuterium	NN
cord-310192-8x37nx4s	102	13	resonates	resonate	VBZ
cord-310192-8x37nx4s	102	14	at	at	IN
cord-310192-8x37nx4s	102	15	a	a	DT
cord-310192-8x37nx4s	102	16	different	different	JJ
cord-310192-8x37nx4s	102	17	frequency	frequency	NN
cord-310192-8x37nx4s	102	18	than	than	IN
cord-310192-8x37nx4s	102	19	protons	proton	NNS
cord-310192-8x37nx4s	102	20	,	,	,
cord-310192-8x37nx4s	102	21	the	the	DT
cord-310192-8x37nx4s	102	22	signals	signal	NNS
cord-310192-8x37nx4s	102	23	are	be	VBP
cord-310192-8x37nx4s	102	24	not	not	RB
cord-310192-8x37nx4s	102	25	observed	observe	VBN
cord-310192-8x37nx4s	102	26	in	in	IN
cord-310192-8x37nx4s	102	27	a	a	DT
cord-310192-8x37nx4s	102	28	proton	proton	NN
cord-310192-8x37nx4s	102	29	detected	detect	VBN
cord-310192-8x37nx4s	102	30	1	1	CD
cord-310192-8x37nx4s	102	31	H-1	H-1	NNP
cord-310192-8x37nx4s	102	32	H	H	NNP
cord-310192-8x37nx4s	102	33	NOESY	NOESY	NNP
cord-310192-8x37nx4s	102	34	spectrum	spectrum	NN
cord-310192-8x37nx4s	102	35	.	.	.
cord-310192-8x37nx4s	103	1	The	the	DT
cord-310192-8x37nx4s	103	2	spectral	spectral	JJ
cord-310192-8x37nx4s	103	3	complexity	complexity	NN
cord-310192-8x37nx4s	103	4	is	be	VBZ
cord-310192-8x37nx4s	103	5	therefore	therefore	RB
cord-310192-8x37nx4s	103	6	significantly	significantly	RB
cord-310192-8x37nx4s	103	7	reduced	reduce	VBN
cord-310192-8x37nx4s	103	8	(	(	-LRB-
cord-310192-8x37nx4s	103	9	Figure	figure	NN
cord-310192-8x37nx4s	103	10	2b	2b	CD
cord-310192-8x37nx4s	103	11	)	)	-RRB-
cord-310192-8x37nx4s	103	12	.	.	.
cord-310192-8x37nx4s	104	1	In	in	IN
cord-310192-8x37nx4s	104	2	addition	addition	NN
cord-310192-8x37nx4s	104	3	to	to	IN
cord-310192-8x37nx4s	104	4	the	the	DT
cord-310192-8x37nx4s	104	5	reduced	reduce	VBN
cord-310192-8x37nx4s	104	6	spectral	spectral	JJ
cord-310192-8x37nx4s	104	7	overlap	overlap	NN
cord-310192-8x37nx4s	104	8	,	,	,
cord-310192-8x37nx4s	104	9	incorporation	incorporation	NN
cord-310192-8x37nx4s	104	10	of	of	IN
cord-310192-8x37nx4s	104	11	deuterium	deuterium	NN
cord-310192-8x37nx4s	104	12	limits	limit	VBZ
cord-310192-8x37nx4s	104	13	pathways	pathway	NNS
cord-310192-8x37nx4s	104	14	for	for	IN
cord-310192-8x37nx4s	104	15	1	1	CD
cord-310192-8x37nx4s	104	16	H-1	H-1	NNP
cord-310192-8x37nx4s	104	17	H	h	NN
cord-310192-8x37nx4s	104	18	spin	spin	NN
cord-310192-8x37nx4s	104	19	diffusion	diffusion	NN
cord-310192-8x37nx4s	104	20	resulting	result	VBG
cord-310192-8x37nx4s	104	21	in	in	IN
cord-310192-8x37nx4s	104	22	narrower	narrow	JJR
cord-310192-8x37nx4s	104	23	line	line	NN
cord-310192-8x37nx4s	104	24	widths	width	NNS
cord-310192-8x37nx4s	104	25	.	.	.
cord-310192-8x37nx4s	105	1	Because	because	IN
cord-310192-8x37nx4s	105	2	this	this	DT
cord-310192-8x37nx4s	105	3	method	method	NN
cord-310192-8x37nx4s	105	4	relies	rely	VBZ
cord-310192-8x37nx4s	105	5	on	on	IN
cord-310192-8x37nx4s	105	6	removing	remove	VBG
cord-310192-8x37nx4s	105	7	signals	signal	NNS
cord-310192-8x37nx4s	105	8	rather	rather	RB
cord-310192-8x37nx4s	105	9	than	than	IN
cord-310192-8x37nx4s	105	10	separating	separate	VBG
cord-310192-8x37nx4s	105	11	the	the	DT
cord-310192-8x37nx4s	105	12	signals	signal	NNS
cord-310192-8x37nx4s	105	13	into	into	IN
cord-310192-8x37nx4s	105	14	a	a	DT
cord-310192-8x37nx4s	105	15	second	second	JJ
cord-310192-8x37nx4s	105	16	or	or	CC
cord-310192-8x37nx4s	105	17	third	third	JJ
cord-310192-8x37nx4s	105	18	dimension	dimension	NN
cord-310192-8x37nx4s	105	19	,	,	,
cord-310192-8x37nx4s	105	20	no	no	DT
cord-310192-8x37nx4s	105	21	one	one	CD
cord-310192-8x37nx4s	105	22	sample	sample	NN
cord-310192-8x37nx4s	105	23	contains	contain	VBZ
cord-310192-8x37nx4s	105	24	F	f	NN
cord-310192-8x37nx4s	105	25	I	i	NN
cord-310192-8x37nx4s	105	26	G	g	NN
cord-310192-8x37nx4s	105	27	U	u	NN
cord-310192-8x37nx4s	105	28	R	r	NN
cord-310192-8x37nx4s	105	29	E	e	NN
cord-310192-8x37nx4s	105	30	2	2	CD
cord-310192-8x37nx4s	105	31	Deuterium	Deuterium	NNP
cord-310192-8x37nx4s	105	32	labeling	labeling	NN
cord-310192-8x37nx4s	105	33	greatly	greatly	RB
cord-310192-8x37nx4s	105	34	improves	improve	VBZ
cord-310192-8x37nx4s	105	35	spectral	spectral	JJ
cord-310192-8x37nx4s	105	36	quality	quality	NN
cord-310192-8x37nx4s	105	37	and	and	CC
cord-310192-8x37nx4s	105	38	simplicity	simplicity	NN
cord-310192-8x37nx4s	105	39	.	.	.
cord-310192-8x37nx4s	106	1	(	(	-LRB-
cord-310192-8x37nx4s	106	2	a	a	LS
cord-310192-8x37nx4s	106	3	)	)	-RRB-
cord-310192-8x37nx4s	106	4	1	1	CD
cord-310192-8x37nx4s	106	5	H-1	H-1	NNP
cord-310192-8x37nx4s	106	6	H	H	NNP
cord-310192-8x37nx4s	106	7	NOESY	NOESY	NNP
cord-310192-8x37nx4s	106	8	spectrum	spectrum	NN
cord-310192-8x37nx4s	106	9	of	of	IN
cord-310192-8x37nx4s	106	10	the	the	DT
cord-310192-8x37nx4s	106	11	full	full	RB
cord-310192-8x37nx4s	106	12	-	-	HYPH
cord-310192-8x37nx4s	106	13	protiated	protiated	JJ
cord-310192-8x37nx4s	106	14	(	(	-LRB-
cord-310192-8x37nx4s	106	15	H	h	NN
cord-310192-8x37nx4s	106	16	,	,	,
cord-310192-8x37nx4s	106	17	unlabeled	unlabeled	JJ
cord-310192-8x37nx4s	106	18	)	)	-RRB-
cord-310192-8x37nx4s	106	19	155	155	CD
cord-310192-8x37nx4s	106	20	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	106	21	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	106	22	core	core	NN
cord-310192-8x37nx4s	106	23	encapsidation	encapsidation	NN
cord-310192-8x37nx4s	106	24	signal	signal	NN
cord-310192-8x37nx4s	106	25	(	(	-LRB-
cord-310192-8x37nx4s	106	26	Keane	Keane	NNP
cord-310192-8x37nx4s	106	27	et	et	NNP
cord-310192-8x37nx4s	106	28	al	al	NNP
cord-310192-8x37nx4s	106	29	.	.	NNP
cord-310192-8x37nx4s	106	30	,	,	,
cord-310192-8x37nx4s	106	31	2015	2015	CD
cord-310192-8x37nx4s	106	32	)	)	-RRB-
cord-310192-8x37nx4s	106	33	is	be	VBZ
cord-310192-8x37nx4s	106	34	characterized	characterize	VBN
cord-310192-8x37nx4s	106	35	by	by	IN
cord-310192-8x37nx4s	106	36	severe	severe	JJ
cord-310192-8x37nx4s	106	37	signal	signal	NN
cord-310192-8x37nx4s	106	38	overlap	overlap	NN
cord-310192-8x37nx4s	106	39	and	and	CC
cord-310192-8x37nx4s	106	40	broad	broad	JJ
cord-310192-8x37nx4s	106	41	line	line	NN
cord-310192-8x37nx4s	106	42	widths	width	NNS
cord-310192-8x37nx4s	106	43	.	.	.
cord-310192-8x37nx4s	107	1	(	(	-LRB-
cord-310192-8x37nx4s	107	2	b	b	LS
cord-310192-8x37nx4s	107	3	)	)	-RRB-
cord-310192-8x37nx4s	107	4	Selective	selective	JJ
cord-310192-8x37nx4s	107	5	deuteration	deuteration	NN
cord-310192-8x37nx4s	107	6	of	of	IN
cord-310192-8x37nx4s	107	7	the	the	DT
cord-310192-8x37nx4s	107	8	sample	sample	NN
cord-310192-8x37nx4s	107	9	results	result	NNS
cord-310192-8x37nx4s	107	10	in	in	IN
cord-310192-8x37nx4s	107	11	spectra	spectrum	NNS
cord-310192-8x37nx4s	107	12	of	of	IN
cord-310192-8x37nx4s	107	13	significantly	significantly	RB
cord-310192-8x37nx4s	107	14	higher	high	JJR
cord-310192-8x37nx4s	107	15	quality	quality	NN
cord-310192-8x37nx4s	107	16	.	.	.
cord-310192-8x37nx4s	108	1	There	there	EX
cord-310192-8x37nx4s	108	2	is	be	VBZ
cord-310192-8x37nx4s	108	3	minimal	minimal	JJ
cord-310192-8x37nx4s	108	4	signal	signal	NN
cord-310192-8x37nx4s	108	5	overlap	overlap	NN
cord-310192-8x37nx4s	108	6	and	and	CC
cord-310192-8x37nx4s	108	7	resonances	resonance	NNS
cord-310192-8x37nx4s	108	8	are	be	VBP
cord-310192-8x37nx4s	108	9	now	now	RB
cord-310192-8x37nx4s	108	10	effectively	effectively	RB
cord-310192-8x37nx4s	108	11	identifiable	identifiable	JJ
cord-310192-8x37nx4s	108	12	by	by	IN
cord-310192-8x37nx4s	108	13	the	the	DT
cord-310192-8x37nx4s	108	14	respective	respective	JJ
cord-310192-8x37nx4s	108	15	labeling	labeling	NN
cord-310192-8x37nx4s	108	16	scheme	scheme	NN
cord-310192-8x37nx4s	108	17	.	.	.
cord-310192-8x37nx4s	109	1	Four	four	CD
cord-310192-8x37nx4s	109	2	different	different	JJ
cord-310192-8x37nx4s	109	3	labeling	labeling	NN
cord-310192-8x37nx4s	109	4	schemes	scheme	NNS
cord-310192-8x37nx4s	109	5	are	be	VBP
cord-310192-8x37nx4s	109	6	shown	show	VBN
cord-310192-8x37nx4s	109	7	:	:	:
cord-310192-8x37nx4s	109	8	A	a	DT
cord-310192-8x37nx4s	109	9	H	h	NN
cord-310192-8x37nx4s	109	10	(	(	-LRB-
cord-310192-8x37nx4s	109	11	adenosines	adenosines	NNP
cord-310192-8x37nx4s	109	12	protiated	protiate	VBD
cord-310192-8x37nx4s	109	13	,	,	,
cord-310192-8x37nx4s	109	14	cytosines	cytosines	NNP
cord-310192-8x37nx4s	109	15	,	,	,
cord-310192-8x37nx4s	109	16	guanosines	guanosines	NNP
cord-310192-8x37nx4s	109	17	,	,	,
cord-310192-8x37nx4s	109	18	and	and	CC
cord-310192-8x37nx4s	109	19	uracils	uracils	NNP
cord-310192-8x37nx4s	109	20	deuterated	deuterated	JJ
cord-310192-8x37nx4s	109	21	)	)	-RRB-
cord-310192-8x37nx4s	109	22	,	,	,
cord-310192-8x37nx4s	109	23	C	C	NNP
cord-310192-8x37nx4s	109	24	H	H	NNP
cord-310192-8x37nx4s	109	25	(	(	-LRB-
cord-310192-8x37nx4s	109	26	cytosines	cytosine	NNS
cord-310192-8x37nx4s	109	27	protiated	protiate	VBD
cord-310192-8x37nx4s	109	28	,	,	,
cord-310192-8x37nx4s	109	29	adenosines	adenosines	NNP
cord-310192-8x37nx4s	109	30	,	,	,
cord-310192-8x37nx4s	109	31	guanosines	guanosines	NNP
cord-310192-8x37nx4s	109	32	,	,	,
cord-310192-8x37nx4s	109	33	and	and	CC
cord-310192-8x37nx4s	109	34	uracils	uracils	NNP
cord-310192-8x37nx4s	109	35	deuterated	deuterated	JJ
cord-310192-8x37nx4s	109	36	)	)	-RRB-
cord-310192-8x37nx4s	109	37	,	,	,
cord-310192-8x37nx4s	109	38	G	G	NNP
cord-310192-8x37nx4s	109	39	H	h	NN
cord-310192-8x37nx4s	109	40	(	(	-LRB-
cord-310192-8x37nx4s	109	41	guanosines	guanosines	NNP
cord-310192-8x37nx4s	109	42	protiated	protiated	NNP
cord-310192-8x37nx4s	109	43	,	,	,
cord-310192-8x37nx4s	109	44	adenosines	adenosines	NNP
cord-310192-8x37nx4s	109	45	,	,	,
cord-310192-8x37nx4s	109	46	cytosines	cytosines	NNPS
cord-310192-8x37nx4s	109	47	,	,	,
cord-310192-8x37nx4s	109	48	and	and	CC
cord-310192-8x37nx4s	109	49	uracils	uracils	NNP
cord-310192-8x37nx4s	109	50	deuterated	deuterated	JJ
cord-310192-8x37nx4s	109	51	)	)	-RRB-
cord-310192-8x37nx4s	109	52	,	,	,
cord-310192-8x37nx4s	109	53	U	U	NNP
cord-310192-8x37nx4s	109	54	6R	6R	NNP
cord-310192-8x37nx4s	109	55	(	(	-LRB-
cord-310192-8x37nx4s	109	56	uracils	uracils	NNP
cord-310192-8x37nx4s	109	57	protiated	protiate	VBD
cord-310192-8x37nx4s	109	58	on	on	IN
cord-310192-8x37nx4s	109	59	the	the	DT
cord-310192-8x37nx4s	109	60	ribose	ribose	NN
cord-310192-8x37nx4s	109	61	and	and	CC
cord-310192-8x37nx4s	109	62	at	at	IN
cord-310192-8x37nx4s	109	63	C	C	NNP
cord-310192-8x37nx4s	109	64	5	5	CD
cord-310192-8x37nx4s	109	65	,	,	,
cord-310192-8x37nx4s	109	66	adenosines	adenosine	NNS
cord-310192-8x37nx4s	109	67	,	,	,
cord-310192-8x37nx4s	109	68	cytosines	cytosines	NNPS
cord-310192-8x37nx4s	109	69	,	,	,
cord-310192-8x37nx4s	109	70	and	and	CC
cord-310192-8x37nx4s	109	71	guanosines	guanosines	NNP
cord-310192-8x37nx4s	109	72	deuterated	deuterated	JJ
cord-310192-8x37nx4s	109	73	)	)	-RRB-
cord-310192-8x37nx4s	109	74	sufficient	sufficient	JJ
cord-310192-8x37nx4s	109	75	structural	structural	JJ
cord-310192-8x37nx4s	109	76	information	information	NN
cord-310192-8x37nx4s	109	77	(	(	-LRB-
cord-310192-8x37nx4s	109	78	Figure	figure	NN
cord-310192-8x37nx4s	109	79	2b	2b	CD
cord-310192-8x37nx4s	109	80	)	)	-RRB-
cord-310192-8x37nx4s	109	81	and	and	CC
cord-310192-8x37nx4s	109	82	many	many	JJ
cord-310192-8x37nx4s	109	83	different	different	JJ
cord-310192-8x37nx4s	109	84	samples	sample	NNS
cord-310192-8x37nx4s	109	85	,	,	,
cord-310192-8x37nx4s	109	86	each	each	DT
cord-310192-8x37nx4s	109	87	with	with	IN
cord-310192-8x37nx4s	109	88	a	a	DT
cord-310192-8x37nx4s	109	89	unique	unique	JJ
cord-310192-8x37nx4s	109	90	labeling	labeling	NN
cord-310192-8x37nx4s	109	91	scheme	scheme	NN
cord-310192-8x37nx4s	109	92	,	,	,
cord-310192-8x37nx4s	109	93	must	must	MD
cord-310192-8x37nx4s	109	94	be	be	VB
cord-310192-8x37nx4s	109	95	prepared	prepared	JJ
cord-310192-8x37nx4s	109	96	to	to	TO
cord-310192-8x37nx4s	109	97	obtain	obtain	VB
cord-310192-8x37nx4s	109	98	full	full	JJ
cord-310192-8x37nx4s	109	99	sequence	sequence	NN
cord-310192-8x37nx4s	109	100	coverage	coverage	NN
cord-310192-8x37nx4s	109	101	of	of	IN
cord-310192-8x37nx4s	109	102	the	the	DT
cord-310192-8x37nx4s	109	103	RNA	RNA	NNP
cord-310192-8x37nx4s	109	104	.	.	.
cord-310192-8x37nx4s	110	1	This	this	DT
cord-310192-8x37nx4s	110	2	approach	approach	NN
cord-310192-8x37nx4s	110	3	is	be	VBZ
cord-310192-8x37nx4s	110	4	labor	labor	NN
cord-310192-8x37nx4s	110	5	intensive	intensive	JJ
cord-310192-8x37nx4s	110	6	and	and	CC
cord-310192-8x37nx4s	110	7	requires	require	VBZ
cord-310192-8x37nx4s	110	8	considerable	considerable	JJ
cord-310192-8x37nx4s	110	9	resources	resource	NNS
cord-310192-8x37nx4s	110	10	and	and	CC
cord-310192-8x37nx4s	110	11	spectrometer	spectrometer	NN
cord-310192-8x37nx4s	110	12	time	time	NN
cord-310192-8x37nx4s	110	13	.	.	.
cord-310192-8x37nx4s	111	1	Nevertheless	nevertheless	RB
cord-310192-8x37nx4s	111	2	,	,	,
cord-310192-8x37nx4s	111	3	this	this	DT
cord-310192-8x37nx4s	111	4	method	method	NN
cord-310192-8x37nx4s	111	5	is	be	VBZ
cord-310192-8x37nx4s	111	6	universally	universally	RB
cord-310192-8x37nx4s	111	7	applicable	applicable	JJ
cord-310192-8x37nx4s	111	8	and	and	CC
cord-310192-8x37nx4s	111	9	has	have	VBZ
cord-310192-8x37nx4s	111	10	been	be	VBN
cord-310192-8x37nx4s	111	11	used	use	VBN
cord-310192-8x37nx4s	111	12	to	to	TO
cord-310192-8x37nx4s	111	13	study	study	VB
cord-310192-8x37nx4s	111	14	a	a	DT
cord-310192-8x37nx4s	111	15	variety	variety	NN
cord-310192-8x37nx4s	111	16	of	of	IN
cord-310192-8x37nx4s	111	17	systems	system	NNS
cord-310192-8x37nx4s	111	18	including	include	VBG
cord-310192-8x37nx4s	111	19	viral	viral	JJ
cord-310192-8x37nx4s	111	20	RNAs	rna	NNS
cord-310192-8x37nx4s	111	21	(	(	-LRB-
cord-310192-8x37nx4s	111	22	D'Souza	D'Souza	NNP
cord-310192-8x37nx4s	111	23	,	,	,
cord-310192-8x37nx4s	111	24	Dey	Dey	NNP
cord-310192-8x37nx4s	111	25	,	,	,
cord-310192-8x37nx4s	111	26	Habib	Habib	NNP
cord-310192-8x37nx4s	111	27	,	,	,
cord-310192-8x37nx4s	111	28	&	&	CC
cord-310192-8x37nx4s	111	29	Summers	Summers	NNPS
cord-310192-8x37nx4s	111	30	,	,	,
cord-310192-8x37nx4s	111	31	2004	2004	CD
cord-310192-8x37nx4s	111	32	;	;	:
cord-310192-8x37nx4s	112	1	Keane	Keane	NNP
cord-310192-8x37nx4s	112	2	et	et	NNP
cord-310192-8x37nx4s	112	3	al	al	NNP
cord-310192-8x37nx4s	112	4	.	.	.
cord-310192-8x37nx4s	113	1	,	,	,
cord-310192-8x37nx4s	113	2	2015	2015	CD
cord-310192-8x37nx4s	113	3	;	;	:
cord-310192-8x37nx4s	113	4	Lu	Lu	NNP
cord-310192-8x37nx4s	113	5	et	et	FW
cord-310192-8x37nx4s	113	6	al	al	NNP
cord-310192-8x37nx4s	113	7	.	.	NNP
cord-310192-8x37nx4s	113	8	,	,	,
cord-310192-8x37nx4s	113	9	2011	2011	CD
cord-310192-8x37nx4s	113	10	;	;	:
cord-310192-8x37nx4s	113	11	Miller	Miller	NNP
cord-310192-8x37nx4s	113	12	,	,	,
cord-310192-8x37nx4s	113	13	Yildiz	Yildiz	NNP
cord-310192-8x37nx4s	113	14	,	,	,
cord-310192-8x37nx4s	113	15	Lo	Lo	NNP
cord-310192-8x37nx4s	113	16	,	,	,
cord-310192-8x37nx4s	113	17	Wang	Wang	NNP
cord-310192-8x37nx4s	113	18	,	,	,
cord-310192-8x37nx4s	113	19	&	&	CC
cord-310192-8x37nx4s	113	20	D'Souza	D'Souza	NNP
cord-310192-8x37nx4s	113	21	,	,	,
cord-310192-8x37nx4s	113	22	2014	2014	CD
cord-310192-8x37nx4s	113	23	)	)	-RRB-
cord-310192-8x37nx4s	113	24	and	and	CC
cord-310192-8x37nx4s	113	25	tetraloop	tetraloop	NN
cord-310192-8x37nx4s	113	26	-	-	HYPH
cord-310192-8x37nx4s	113	27	receptor	receptor	NN
cord-310192-8x37nx4s	113	28	complexes	complex	NNS
cord-310192-8x37nx4s	114	1	(	(	-LRB-
cord-310192-8x37nx4s	114	2	Davis	Davis	NNP
cord-310192-8x37nx4s	114	3	et	et	NNP
cord-310192-8x37nx4s	114	4	al	al	NNP
cord-310192-8x37nx4s	114	5	.	.	NNP
cord-310192-8x37nx4s	114	6	,	,	,
cord-310192-8x37nx4s	114	7	2005	2005	CD
cord-310192-8x37nx4s	114	8	)	)	-RRB-
cord-310192-8x37nx4s	114	9	.	.	.
cord-310192-8x37nx4s	115	1	Notably	notably	RB
cord-310192-8x37nx4s	115	2	,	,	,
cord-310192-8x37nx4s	115	3	this	this	DT
cord-310192-8x37nx4s	115	4	approach	approach	NN
cord-310192-8x37nx4s	115	5	was	be	VBD
cord-310192-8x37nx4s	115	6	recently	recently	RB
cord-310192-8x37nx4s	115	7	used	use	VBN
cord-310192-8x37nx4s	115	8	to	to	TO
cord-310192-8x37nx4s	115	9	probe	probe	VB
cord-310192-8x37nx4s	115	10	the	the	DT
cord-310192-8x37nx4s	115	11	structure	structure	NN
cord-310192-8x37nx4s	115	12	of	of	IN
cord-310192-8x37nx4s	115	13	the	the	DT
cord-310192-8x37nx4s	115	14	230	230	CD
cord-310192-8x37nx4s	115	15	kDa	kDa	NNP
cord-310192-8x37nx4s	115	16	HIV	HIV	NNP
cord-310192-8x37nx4s	115	17	5	5	CD
cord-310192-8x37nx4s	115	18	0	0	CD
cord-310192-8x37nx4s	115	19	leader	leader	NN
cord-310192-8x37nx4s	115	20	and	and	CC
cord-310192-8x37nx4s	115	21	provide	provide	VB
cord-310192-8x37nx4s	115	22	insight	insight	NN
cord-310192-8x37nx4s	115	23	into	into	IN
cord-310192-8x37nx4s	115	24	its	-PRON-	PRP$
cord-310192-8x37nx4s	115	25	dimerization	dimerization	NN
cord-310192-8x37nx4s	115	26	mechanism	mechanism	NN
cord-310192-8x37nx4s	115	27	(	(	-LRB-
cord-310192-8x37nx4s	115	28	Keane	Keane	NNP
cord-310192-8x37nx4s	115	29	et	et	NNP
cord-310192-8x37nx4s	115	30	al	al	NNP
cord-310192-8x37nx4s	115	31	.	.	NNP
cord-310192-8x37nx4s	115	32	,	,	,
cord-310192-8x37nx4s	115	33	2016	2016	CD
cord-310192-8x37nx4s	115	34	)	)	-RRB-
cord-310192-8x37nx4s	115	35	.	.	.
cord-310192-8x37nx4s	116	1	Partially	partially	RB
cord-310192-8x37nx4s	116	2	or	or	CC
cord-310192-8x37nx4s	116	3	fully	fully	RB
cord-310192-8x37nx4s	116	4	deuterated	deuterate	VBN
cord-310192-8x37nx4s	116	5	ribonucleotide	ribonucleotide	NN
cord-310192-8x37nx4s	116	6	triphosphates	triphosphate	NNS
cord-310192-8x37nx4s	116	7	(	(	-LRB-
cord-310192-8x37nx4s	116	8	rNTPs	rNTPs	NFP
cord-310192-8x37nx4s	116	9	)	)	-RRB-
cord-310192-8x37nx4s	116	10	can	can	MD
cord-310192-8x37nx4s	116	11	be	be	VB
cord-310192-8x37nx4s	116	12	purchased	purchase	VBN
cord-310192-8x37nx4s	116	13	or	or	CC
cord-310192-8x37nx4s	116	14	produced	produce	VBN
cord-310192-8x37nx4s	116	15	in	in	IN
cord-310192-8x37nx4s	116	16	the	the	DT
cord-310192-8x37nx4s	116	17	laboratory	laboratory	NN
cord-310192-8x37nx4s	116	18	using	use	VBG
cord-310192-8x37nx4s	116	19	either	either	CC
cord-310192-8x37nx4s	116	20	chemical	chemical	JJ
cord-310192-8x37nx4s	116	21	or	or	CC
cord-310192-8x37nx4s	116	22	enzymatic	enzymatic	JJ
cord-310192-8x37nx4s	116	23	methods	method	NNS
cord-310192-8x37nx4s	116	24	(	(	-LRB-
cord-310192-8x37nx4s	116	25	Huang	Huang	NNP
cord-310192-8x37nx4s	116	26	,	,	,
cord-310192-8x37nx4s	116	27	Yu	Yu	NNP
cord-310192-8x37nx4s	116	28	,	,	,
cord-310192-8x37nx4s	116	29	LeProust	LeProust	NNP
cord-310192-8x37nx4s	116	30	,	,	,
cord-310192-8x37nx4s	116	31	&	&	CC
cord-310192-8x37nx4s	116	32	Gao	Gao	NNP
cord-310192-8x37nx4s	116	33	,	,	,
cord-310192-8x37nx4s	116	34	1997	1997	CD
cord-310192-8x37nx4s	116	35	;	;	:
cord-310192-8x37nx4s	116	36	Lu	Lu	NNP
cord-310192-8x37nx4s	116	37	et	et	FW
cord-310192-8x37nx4s	116	38	al	al	NNP
cord-310192-8x37nx4s	116	39	.	.	NNP
cord-310192-8x37nx4s	116	40	,	,	,
cord-310192-8x37nx4s	116	41	2010	2010	CD
cord-310192-8x37nx4s	116	42	;	;	:
cord-310192-8x37nx4s	116	43	Scott	Scott	NNP
cord-310192-8x37nx4s	116	44	,	,	,
cord-310192-8x37nx4s	116	45	Tolbert	Tolbert	NNP
cord-310192-8x37nx4s	116	46	,	,	,
cord-310192-8x37nx4s	116	47	&	&	CC
cord-310192-8x37nx4s	116	48	Williamson	Williamson	NNP
cord-310192-8x37nx4s	116	49	,	,	,
cord-310192-8x37nx4s	116	50	2000	2000	CD
cord-310192-8x37nx4s	116	51	)	)	-RRB-
cord-310192-8x37nx4s	116	52	.	.	.
cord-310192-8x37nx4s	117	1	rNTPs	rntps	CD
cord-310192-8x37nx4s	117	2	may	may	MD
cord-310192-8x37nx4s	117	3	be	be	VB
cord-310192-8x37nx4s	117	4	deuterated	deuterate	VBN
cord-310192-8x37nx4s	117	5	at	at	IN
cord-310192-8x37nx4s	117	6	nonexchangeable	nonexchangeable	JJ
cord-310192-8x37nx4s	117	7	positions	position	NNS
cord-310192-8x37nx4s	117	8	within	within	IN
cord-310192-8x37nx4s	117	9	the	the	DT
cord-310192-8x37nx4s	117	10	base	base	NN
cord-310192-8x37nx4s	117	11	and/or	and/or	CC
cord-310192-8x37nx4s	117	12	the	the	DT
cord-310192-8x37nx4s	117	13	ribose	ribose	NN
cord-310192-8x37nx4s	117	14	and	and	CC
cord-310192-8x37nx4s	117	15	can	can	MD
cord-310192-8x37nx4s	117	16	subsequently	subsequently	RB
cord-310192-8x37nx4s	117	17	be	be	VB
cord-310192-8x37nx4s	117	18	used	use	VBN
cord-310192-8x37nx4s	117	19	in	in	IN
cord-310192-8x37nx4s	117	20	the	the	DT
cord-310192-8x37nx4s	117	21	enzymatic	enzymatic	JJ
cord-310192-8x37nx4s	117	22	synthesis	synthesis	NN
cord-310192-8x37nx4s	117	23	of	of	IN
cord-310192-8x37nx4s	117	24	RNA	RNA	NNP
cord-310192-8x37nx4s	117	25	using	use	VBG
cord-310192-8x37nx4s	117	26	T7	T7	NNP
cord-310192-8x37nx4s	117	27	RNA	RNA	NNP
cord-310192-8x37nx4s	117	28	polymerase	polymerase	NN
cord-310192-8x37nx4s	117	29	in	in	IN
cord-310192-8x37nx4s	117	30	place	place	NN
cord-310192-8x37nx4s	117	31	of	of	IN
cord-310192-8x37nx4s	117	32	fully	fully	RB
cord-310192-8x37nx4s	117	33	protiated	protiate	VBN
cord-310192-8x37nx4s	117	34	rNTPs	rNTPs	.
cord-310192-8x37nx4s	118	1	(	(	-LRB-
cord-310192-8x37nx4s	118	2	Batey	Batey	NNP
cord-310192-8x37nx4s	118	3	,	,	,
cord-310192-8x37nx4s	118	4	Battiste	Battiste	NNP
cord-310192-8x37nx4s	118	5	,	,	,
cord-310192-8x37nx4s	118	6	&	&	CC
cord-310192-8x37nx4s	118	7	Williamson	Williamson	NNP
cord-310192-8x37nx4s	118	8	,	,	,
cord-310192-8x37nx4s	118	9	1995	1995	CD
cord-310192-8x37nx4s	118	10	;	;	:
cord-310192-8x37nx4s	118	11	Batey	Batey	NNP
cord-310192-8x37nx4s	118	12	,	,	,
cord-310192-8x37nx4s	118	13	Inada	Inada	NNP
cord-310192-8x37nx4s	118	14	,	,	,
cord-310192-8x37nx4s	118	15	Kujawinski	Kujawinski	NNP
cord-310192-8x37nx4s	118	16	,	,	,
cord-310192-8x37nx4s	118	17	Puglisi	Puglisi	NNP
cord-310192-8x37nx4s	118	18	,	,	,
cord-310192-8x37nx4s	118	19	&	&	CC
cord-310192-8x37nx4s	118	20	Williamson	Williamson	NNP
cord-310192-8x37nx4s	118	21	,	,	,
cord-310192-8x37nx4s	118	22	1992	1992	CD
cord-310192-8x37nx4s	118	23	;	;	:
cord-310192-8x37nx4s	118	24	Scott	Scott	NNP
cord-310192-8x37nx4s	118	25	et	et	NNP
cord-310192-8x37nx4s	118	26	al	al	NNP
cord-310192-8x37nx4s	118	27	.	.	NNP
cord-310192-8x37nx4s	118	28	,	,	,
cord-310192-8x37nx4s	118	29	2000	2000	CD
cord-310192-8x37nx4s	118	30	)	)	-RRB-
cord-310192-8x37nx4s	118	31	.	.	.
cord-310192-8x37nx4s	119	1	In	in	IN
cord-310192-8x37nx4s	119	2	much	much	RB
cord-310192-8x37nx4s	119	3	the	the	DT
cord-310192-8x37nx4s	119	4	same	same	JJ
cord-310192-8x37nx4s	119	5	way	way	NN
cord-310192-8x37nx4s	119	6	that	that	WDT
cord-310192-8x37nx4s	119	7	partially	partially	RB
cord-310192-8x37nx4s	119	8	or	or	CC
cord-310192-8x37nx4s	119	9	fully	fully	RB
cord-310192-8x37nx4s	119	10	deuterated	deuterated	JJ
cord-310192-8x37nx4s	119	11	rNTPs	rNTPs	''
cord-310192-8x37nx4s	119	12	can	can	MD
cord-310192-8x37nx4s	119	13	be	be	VB
cord-310192-8x37nx4s	119	14	incorporated	incorporate	VBN
cord-310192-8x37nx4s	119	15	into	into	IN
cord-310192-8x37nx4s	119	16	an	an	DT
cord-310192-8x37nx4s	119	17	RNA	RNA	NNP
cord-310192-8x37nx4s	119	18	using	use	VBG
cord-310192-8x37nx4s	119	19	in	in	IN
cord-310192-8x37nx4s	119	20	vitro	vitro	FW
cord-310192-8x37nx4s	119	21	transcription	transcription	NN
cord-310192-8x37nx4s	119	22	,	,	,
cord-310192-8x37nx4s	119	23	so	so	RB
cord-310192-8x37nx4s	119	24	too	too	RB
cord-310192-8x37nx4s	119	25	can	can	MD
cord-310192-8x37nx4s	119	26	other	other	JJ
cord-310192-8x37nx4s	119	27	common	common	JJ
cord-310192-8x37nx4s	119	28	NMR	nmr	NN
cord-310192-8x37nx4s	119	29	-	-	HYPH
cord-310192-8x37nx4s	119	30	active	active	JJ
cord-310192-8x37nx4s	119	31	isotopes	isotope	NNS
cord-310192-8x37nx4s	119	32	.	.	.
cord-310192-8x37nx4s	120	1	Isotopically	Isotopically	NNP
cord-310192-8x37nx4s	120	2	enriched	enrich	VBD
cord-310192-8x37nx4s	120	3	13	13	CD
cord-310192-8x37nx4s	120	4	C	c	NN
cord-310192-8x37nx4s	120	5	and	and	CC
cord-310192-8x37nx4s	120	6	15	15	CD
cord-310192-8x37nx4s	120	7	N	n	CD
cord-310192-8x37nx4s	120	8	rNTPs	rntps	CD
cord-310192-8x37nx4s	120	9	have	have	VBP
cord-310192-8x37nx4s	120	10	widely	widely	RB
cord-310192-8x37nx4s	120	11	been	be	VBN
cord-310192-8x37nx4s	120	12	used	use	VBN
cord-310192-8x37nx4s	120	13	in	in	IN
cord-310192-8x37nx4s	120	14	NMR	NMR	NNP
cord-310192-8x37nx4s	120	15	experiments	experiment	NNS
cord-310192-8x37nx4s	120	16	to	to	TO
cord-310192-8x37nx4s	120	17	study	study	VB
cord-310192-8x37nx4s	120	18	RNA	RNA	NNP
cord-310192-8x37nx4s	120	19	structure	structure	NN
cord-310192-8x37nx4s	120	20	,	,	,
cord-310192-8x37nx4s	120	21	dynamics	dynamic	NNS
cord-310192-8x37nx4s	120	22	,	,	,
cord-310192-8x37nx4s	120	23	and	and	CC
cord-310192-8x37nx4s	120	24	ligand	ligand	NN
cord-310192-8x37nx4s	120	25	binding	binding	NN
cord-310192-8x37nx4s	120	26	(	(	-LRB-
cord-310192-8x37nx4s	120	27	Batey	Batey	NNP
cord-310192-8x37nx4s	120	28	et	et	NNP
cord-310192-8x37nx4s	120	29	al	al	NNP
cord-310192-8x37nx4s	120	30	.	.	NNP
cord-310192-8x37nx4s	120	31	,	,	,
cord-310192-8x37nx4s	120	32	1995	1995	CD
cord-310192-8x37nx4s	120	33	;	;	:
cord-310192-8x37nx4s	121	1	Nikonowicz	Nikonowicz	NNP
cord-310192-8x37nx4s	121	2	et	et	NNP
cord-310192-8x37nx4s	121	3	al	al	NNP
cord-310192-8x37nx4s	121	4	.	.	NNP
cord-310192-8x37nx4s	121	5	,	,	,
cord-310192-8x37nx4s	121	6	1992	1992	CD
cord-310192-8x37nx4s	121	7	)	)	-RRB-
cord-310192-8x37nx4s	121	8	.	.	.
cord-310192-8x37nx4s	122	1	Traditionally	traditionally	RB
cord-310192-8x37nx4s	122	2	,	,	,
cord-310192-8x37nx4s	122	3	these	these	DT
cord-310192-8x37nx4s	122	4	studies	study	NNS
cord-310192-8x37nx4s	122	5	have	have	VBP
cord-310192-8x37nx4s	122	6	been	be	VBN
cord-310192-8x37nx4s	122	7	applied	apply	VBN
cord-310192-8x37nx4s	122	8	to	to	IN
cord-310192-8x37nx4s	122	9	relatively	relatively	RB
cord-310192-8x37nx4s	122	10	small	small	JJ
cord-310192-8x37nx4s	122	11	RNAs	rna	NNS
cord-310192-8x37nx4s	122	12	.	.	.
cord-310192-8x37nx4s	123	1	The	the	DT
cord-310192-8x37nx4s	123	2	ability	ability	NN
cord-310192-8x37nx4s	123	3	to	to	TO
cord-310192-8x37nx4s	123	4	site	site	NN
cord-310192-8x37nx4s	123	5	-	-	:
cord-310192-8x37nx4s	123	6	specifically	specifically	RB
cord-310192-8x37nx4s	123	7	incorporate	incorporate	VB
cord-310192-8x37nx4s	123	8	13	13	CD
cord-310192-8x37nx4s	123	9	C	C	NNP
cord-310192-8x37nx4s	123	10	labels	label	NNS
cord-310192-8x37nx4s	123	11	within	within	IN
cord-310192-8x37nx4s	123	12	an	an	DT
cord-310192-8x37nx4s	123	13	RNA	RNA	NNP
cord-310192-8x37nx4s	123	14	ribose	ribose	NN
cord-310192-8x37nx4s	123	15	and/or	and/or	CC
cord-310192-8x37nx4s	123	16	base	base	NN
cord-310192-8x37nx4s	123	17	makes	make	VBZ
cord-310192-8x37nx4s	123	18	NMR	NMR	NNP
cord-310192-8x37nx4s	123	19	spectroscopy	spectroscopy	VB
cord-310192-8x37nx4s	123	20	a	a	DT
cord-310192-8x37nx4s	123	21	powerful	powerful	JJ
cord-310192-8x37nx4s	123	22	tool	tool	NN
cord-310192-8x37nx4s	123	23	for	for	IN
cord-310192-8x37nx4s	123	24	dynamics	dynamic	NNS
cord-310192-8x37nx4s	123	25	studies	study	NNS
cord-310192-8x37nx4s	123	26	of	of	IN
cord-310192-8x37nx4s	123	27	large	large	JJ
cord-310192-8x37nx4s	123	28	RNAs	rna	NNS
cord-310192-8x37nx4s	123	29	,	,	,
cord-310192-8x37nx4s	123	30	expanding	expand	VBG
cord-310192-8x37nx4s	123	31	the	the	DT
cord-310192-8x37nx4s	123	32	types	type	NNS
cord-310192-8x37nx4s	123	33	of	of	IN
cord-310192-8x37nx4s	123	34	experiments	experiment	NNS
cord-310192-8x37nx4s	123	35	that	that	WDT
cord-310192-8x37nx4s	123	36	can	can	MD
cord-310192-8x37nx4s	123	37	be	be	VB
cord-310192-8x37nx4s	123	38	conducted	conduct	VBN
cord-310192-8x37nx4s	123	39	and	and	CC
cord-310192-8x37nx4s	123	40	simplifying	simplify	VBG
cord-310192-8x37nx4s	123	41	analysis	analysis	NN
cord-310192-8x37nx4s	123	42	(	(	-LRB-
cord-310192-8x37nx4s	123	43	see	see	VB
cord-310192-8x37nx4s	123	44	data	data	NN
cord-310192-8x37nx4s	123	45	acquisition	acquisition	NN
cord-310192-8x37nx4s	123	46	and	and	CC
cord-310192-8x37nx4s	123	47	analysis	analysis	NN
cord-310192-8x37nx4s	123	48	advancements	advancement	NNS
cord-310192-8x37nx4s	123	49	below	below	RB
cord-310192-8x37nx4s	123	50	)	)	-RRB-
cord-310192-8x37nx4s	123	51	.	.	.
cord-310192-8x37nx4s	124	1	Compared	compare	VBN
cord-310192-8x37nx4s	124	2	to	to	TO
cord-310192-8x37nx4s	124	3	uniform	uniform	VB
cord-310192-8x37nx4s	124	4	13	13	CD
cord-310192-8x37nx4s	124	5	C	c	NN
cord-310192-8x37nx4s	124	6	incorporation	incorporation	NN
cord-310192-8x37nx4s	124	7	,	,	,
cord-310192-8x37nx4s	124	8	site	site	NN
cord-310192-8x37nx4s	124	9	specific	specific	JJ
cord-310192-8x37nx4s	124	10	incorporation	incorporation	NN
cord-310192-8x37nx4s	124	11	of	of	IN
cord-310192-8x37nx4s	124	12	13	13	CD
cord-310192-8x37nx4s	124	13	C	C	NNP
cord-310192-8x37nx4s	124	14	labels	label	NNS
cord-310192-8x37nx4s	124	15	allows	allow	VBZ
cord-310192-8x37nx4s	124	16	for	for	IN
cord-310192-8x37nx4s	124	17	reduced	reduce	VBN
cord-310192-8x37nx4s	124	18	spectral	spectral	JJ
cord-310192-8x37nx4s	124	19	crowding	crowding	NN
cord-310192-8x37nx4s	124	20	while	while	IN
cord-310192-8x37nx4s	124	21	eliminating	eliminate	VBG
cord-310192-8x37nx4s	124	22	the	the	DT
cord-310192-8x37nx4s	124	23	strong	strong	JJ
cord-310192-8x37nx4s	124	24	13	13	CD
cord-310192-8x37nx4s	124	25	C-13	C-13	NNP
cord-310192-8x37nx4s	124	26	C	c	NN
cord-310192-8x37nx4s	124	27	scalar	scalar	NN
cord-310192-8x37nx4s	124	28	couplings	coupling	NNS
cord-310192-8x37nx4s	124	29	thereby	thereby	RB
cord-310192-8x37nx4s	124	30	increasing	increase	VBG
cord-310192-8x37nx4s	124	31	signal	signal	NN
cord-310192-8x37nx4s	124	32	-	-	HYPH
cord-310192-8x37nx4s	124	33	to	to	IN
cord-310192-8x37nx4s	124	34	-	-	HYPH
cord-310192-8x37nx4s	124	35	noise	noise	NN
cord-310192-8x37nx4s	124	36	ratios	ratio	NNS
cord-310192-8x37nx4s	124	37	and	and	CC
cord-310192-8x37nx4s	124	38	facilitating	facilitate	VBG
cord-310192-8x37nx4s	124	39	direct	direct	JJ
cord-310192-8x37nx4s	124	40	carbon	carbon	NN
cord-310192-8x37nx4s	124	41	detection	detection	NN
cord-310192-8x37nx4s	124	42	experiments	experiment	NNS
cord-310192-8x37nx4s	124	43	(	(	-LRB-
cord-310192-8x37nx4s	124	44	Alvarado	Alvarado	NNP
cord-310192-8x37nx4s	124	45	et	et	NNP
cord-310192-8x37nx4s	124	46	al	al	NNP
cord-310192-8x37nx4s	124	47	.	.	NNP
cord-310192-8x37nx4s	124	48	,	,	,
cord-310192-8x37nx4s	124	49	2014	2014	CD
cord-310192-8x37nx4s	124	50	;	;	:
cord-310192-8x37nx4s	124	51	Longhini	Longhini	NNP
cord-310192-8x37nx4s	124	52	et	et	NNP
cord-310192-8x37nx4s	124	53	al	al	NNP
cord-310192-8x37nx4s	124	54	.	.	NNP
cord-310192-8x37nx4s	124	55	,	,	,
cord-310192-8x37nx4s	124	56	2016	2016	CD
cord-310192-8x37nx4s	124	57	;	;	:
cord-310192-8x37nx4s	124	58	Lukavsky	Lukavsky	NNP
cord-310192-8x37nx4s	124	59	&	&	CC
cord-310192-8x37nx4s	124	60	Puglisi	Puglisi	NNP
cord-310192-8x37nx4s	124	61	,	,	,
cord-310192-8x37nx4s	124	62	2005	2005	CD
cord-310192-8x37nx4s	124	63	;	;	:
cord-310192-8x37nx4s	124	64	Marchant	Marchant	NNP
cord-310192-8x37nx4s	124	65	,	,	,
cord-310192-8x37nx4s	124	66	Bax	Bax	NNP
cord-310192-8x37nx4s	124	67	,	,	,
cord-310192-8x37nx4s	124	68	&	&	CC
cord-310192-8x37nx4s	124	69	Summers	Summers	NNPS
cord-310192-8x37nx4s	124	70	,	,	,
cord-310192-8x37nx4s	124	71	2018	2018	CD
cord-310192-8x37nx4s	124	72	)	)	-RRB-
cord-310192-8x37nx4s	124	73	.	.	.
cord-310192-8x37nx4s	125	1	Drawing	draw	VBG
cord-310192-8x37nx4s	125	2	inspiration	inspiration	NN
cord-310192-8x37nx4s	125	3	from	from	IN
cord-310192-8x37nx4s	125	4	earlier	early	JJR
cord-310192-8x37nx4s	125	5	synthetic	synthetic	JJ
cord-310192-8x37nx4s	125	6	strategies	strategy	NNS
cord-310192-8x37nx4s	125	7	(	(	-LRB-
cord-310192-8x37nx4s	125	8	SantaLucia	SantaLucia	NNP
cord-310192-8x37nx4s	125	9	,	,	,
cord-310192-8x37nx4s	125	10	Shen	Shen	NNP
cord-310192-8x37nx4s	125	11	,	,	,
cord-310192-8x37nx4s	125	12	Cai	Cai	NNP
cord-310192-8x37nx4s	125	13	,	,	,
cord-310192-8x37nx4s	125	14	Lewis	Lewis	NNP
cord-310192-8x37nx4s	125	15	,	,	,
cord-310192-8x37nx4s	125	16	&	&	CC
cord-310192-8x37nx4s	125	17	Tinoco	Tinoco	NNP
cord-310192-8x37nx4s	125	18	,	,	,
cord-310192-8x37nx4s	125	19	1995	1995	CD
cord-310192-8x37nx4s	125	20	)	)	-RRB-
cord-310192-8x37nx4s	125	21	,	,	,
cord-310192-8x37nx4s	125	22	the	the	DT
cord-310192-8x37nx4s	125	23	Dayie	Dayie	NNP
cord-310192-8x37nx4s	125	24	lab	lab	NN
cord-310192-8x37nx4s	125	25	has	have	VBZ
cord-310192-8x37nx4s	125	26	developed	develop	VBN
cord-310192-8x37nx4s	125	27	a	a	DT
cord-310192-8x37nx4s	125	28	chemo	chemo	NN
cord-310192-8x37nx4s	125	29	-	-	HYPH
cord-310192-8x37nx4s	125	30	enzymatic	enzymatic	JJ
cord-310192-8x37nx4s	125	31	method	method	NN
cord-310192-8x37nx4s	125	32	to	to	TO
cord-310192-8x37nx4s	125	33	produce	produce	VB
cord-310192-8x37nx4s	125	34	isotopically	isotopically	RB
cord-310192-8x37nx4s	125	35	enriched	enrich	VBN
cord-310192-8x37nx4s	125	36	pyrimidines	pyrimidine	NNS
cord-310192-8x37nx4s	125	37	(	(	-LRB-
cord-310192-8x37nx4s	125	38	Alvarado	Alvarado	NNP
cord-310192-8x37nx4s	125	39	et	et	NNP
cord-310192-8x37nx4s	125	40	al	al	NNP
cord-310192-8x37nx4s	125	41	.	.	NNP
cord-310192-8x37nx4s	125	42	,	,	,
cord-310192-8x37nx4s	125	43	2014	2014	CD
cord-310192-8x37nx4s	125	44	)	)	-RRB-
cord-310192-8x37nx4s	125	45	and	and	CC
cord-310192-8x37nx4s	125	46	purines	purine	NNS
cord-310192-8x37nx4s	125	47	(	(	-LRB-
cord-310192-8x37nx4s	125	48	Longhini	Longhini	NNP
cord-310192-8x37nx4s	125	49	et	et	NNP
cord-310192-8x37nx4s	125	50	al	al	NNP
cord-310192-8x37nx4s	125	51	.	.	NNP
cord-310192-8x37nx4s	125	52	,	,	,
cord-310192-8x37nx4s	125	53	2016	2016	CD
cord-310192-8x37nx4s	125	54	)	)	-RRB-
cord-310192-8x37nx4s	125	55	with	with	IN
cord-310192-8x37nx4s	125	56	different	different	JJ
cord-310192-8x37nx4s	125	57	13	13	CD
cord-310192-8x37nx4s	125	58	C	c	NN
cord-310192-8x37nx4s	125	59	and/or	and/or	CC
cord-310192-8x37nx4s	125	60	15	15	CD
cord-310192-8x37nx4s	125	61	N	n	CD
cord-310192-8x37nx4s	125	62	patterns	pattern	NNS
cord-310192-8x37nx4s	125	63	.	.	.
cord-310192-8x37nx4s	126	1	The	the	DT
cord-310192-8x37nx4s	126	2	incorporation	incorporation	NN
cord-310192-8x37nx4s	126	3	of	of	IN
cord-310192-8x37nx4s	126	4	site	site	NN
cord-310192-8x37nx4s	126	5	specifically	specifically	RB
cord-310192-8x37nx4s	126	6	labeled	label	VBN
cord-310192-8x37nx4s	126	7	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	126	8	into	into	IN
cord-310192-8x37nx4s	126	9	large	large	JJ
cord-310192-8x37nx4s	126	10	RNAs	rna	NNS
cord-310192-8x37nx4s	126	11	strongly	strongly	RB
cord-310192-8x37nx4s	126	12	reduced	reduce	VBD
cord-310192-8x37nx4s	126	13	spectral	spectral	JJ
cord-310192-8x37nx4s	126	14	crowding	crowding	NN
cord-310192-8x37nx4s	126	15	and	and	CC
cord-310192-8x37nx4s	126	16	removed	remove	VBD
cord-310192-8x37nx4s	126	17	13	13	CD
cord-310192-8x37nx4s	126	18	C-13	C-13	NNP
cord-310192-8x37nx4s	126	19	C	C	NNP
cord-310192-8x37nx4s	126	20	J	j	NN
cord-310192-8x37nx4s	126	21	-	-	HYPH
cord-310192-8x37nx4s	126	22	coupling	coupling	NNP
cord-310192-8x37nx4s	126	23	,	,	,
cord-310192-8x37nx4s	126	24	allowing	allow	VBG
cord-310192-8x37nx4s	126	25	study	study	NN
cord-310192-8x37nx4s	126	26	of	of	IN
cord-310192-8x37nx4s	126	27	large	large	JJ
cord-310192-8x37nx4s	126	28	RNAs	rna	NNS
cord-310192-8x37nx4s	126	29	by	by	IN
cord-310192-8x37nx4s	126	30	TROSY	TROSY	NNP
cord-310192-8x37nx4s	126	31	(	(	-LRB-
cord-310192-8x37nx4s	126	32	Pervushin	Pervushin	NNP
cord-310192-8x37nx4s	126	33	,	,	,
cord-310192-8x37nx4s	126	34	Riek	Riek	NNP
cord-310192-8x37nx4s	126	35	,	,	,
cord-310192-8x37nx4s	126	36	Wider	Wider	NNP
cord-310192-8x37nx4s	126	37	,	,	,
cord-310192-8x37nx4s	126	38	&	&	CC
cord-310192-8x37nx4s	126	39	Wuthrich	Wuthrich	NNP
cord-310192-8x37nx4s	126	40	,	,	,
cord-310192-8x37nx4s	126	41	1997	1997	CD
cord-310192-8x37nx4s	126	42	)	)	-RRB-
cord-310192-8x37nx4s	126	43	experiments	experiment	NNS
cord-310192-8x37nx4s	126	44	and	and	CC
cord-310192-8x37nx4s	126	45	enabling	enable	VBG
cord-310192-8x37nx4s	126	46	new	new	JJ
cord-310192-8x37nx4s	126	47	method	method	NN
cord-310192-8x37nx4s	126	48	for	for	IN
cord-310192-8x37nx4s	126	49	RNA	RNA	NNP
cord-310192-8x37nx4s	126	50	NOESY	NOESY	NNP
cord-310192-8x37nx4s	126	51	assignment	assignment	NN
cord-310192-8x37nx4s	126	52	with	with	IN
cord-310192-8x37nx4s	126	53	improved	improved	JJ
cord-310192-8x37nx4s	126	54	signal	signal	JJ
cord-310192-8x37nx4s	126	55	intensity	intensity	NN
cord-310192-8x37nx4s	126	56	of	of	IN
cord-310192-8x37nx4s	126	57	C	C	NNP
cord-310192-8x37nx4s	126	58	6	6	CD
cord-310192-8x37nx4s	126	59	and	and	CC
cord-310192-8x37nx4s	126	60	C	C	NNP
cord-310192-8x37nx4s	126	61	8	8	CD
cord-310192-8x37nx4s	126	62	protons	proton	NNS
cord-310192-8x37nx4s	126	63	.	.	.
cord-310192-8x37nx4s	127	1	In	in	IN
cord-310192-8x37nx4s	127	2	addition	addition	NN
cord-310192-8x37nx4s	127	3	,	,	,
cord-310192-8x37nx4s	127	4	dynamics	dynamic	NNS
cord-310192-8x37nx4s	127	5	studies	study	NNS
cord-310192-8x37nx4s	127	6	of	of	IN
cord-310192-8x37nx4s	127	7	RNA	RNA	NNP
cord-310192-8x37nx4s	127	8	could	could	MD
cord-310192-8x37nx4s	127	9	also	also	RB
cord-310192-8x37nx4s	127	10	benefit	benefit	VB
cord-310192-8x37nx4s	127	11	from	from	IN
cord-310192-8x37nx4s	127	12	using	use	VBG
cord-310192-8x37nx4s	127	13	those	those	DT
cord-310192-8x37nx4s	127	14	selectively	selectively	RB
cord-310192-8x37nx4s	127	15	labeled	label	VBN
cord-310192-8x37nx4s	127	16	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	127	17	(	(	-LRB-
cord-310192-8x37nx4s	127	18	LeBlanc	LeBlanc	NNP
cord-310192-8x37nx4s	127	19	,	,	,
cord-310192-8x37nx4s	127	20	Longhini	Longhini	NNP
cord-310192-8x37nx4s	127	21	,	,	,
cord-310192-8x37nx4s	127	22	Tugarinov	Tugarinov	NNP
cord-310192-8x37nx4s	127	23	,	,	,
cord-310192-8x37nx4s	127	24	&	&	CC
cord-310192-8x37nx4s	127	25	Dayie	Dayie	NNP
cord-310192-8x37nx4s	127	26	,	,	,
cord-310192-8x37nx4s	127	27	2018	2018	CD
cord-310192-8x37nx4s	127	28	)	)	-RRB-
cord-310192-8x37nx4s	127	29	.	.	.
cord-310192-8x37nx4s	128	1	As	as	IN
cord-310192-8x37nx4s	128	2	discussed	discuss	VBN
cord-310192-8x37nx4s	128	3	above	above	RB
cord-310192-8x37nx4s	128	4	,	,	,
cord-310192-8x37nx4s	128	5	the	the	DT
cord-310192-8x37nx4s	128	6	uniform	uniform	JJ
cord-310192-8x37nx4s	128	7	incorporation	incorporation	NN
cord-310192-8x37nx4s	128	8	of	of	IN
cord-310192-8x37nx4s	128	9	specifically	specifically	RB
cord-310192-8x37nx4s	128	10	labeled	label	VBN
cord-310192-8x37nx4s	128	11	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	128	12	can	can	MD
cord-310192-8x37nx4s	128	13	greatly	greatly	RB
cord-310192-8x37nx4s	128	14	facilitate	facilitate	VB
cord-310192-8x37nx4s	128	15	NMR	NMR	NNP
cord-310192-8x37nx4s	128	16	studies	study	NNS
cord-310192-8x37nx4s	128	17	of	of	IN
cord-310192-8x37nx4s	128	18	large	large	JJ
cord-310192-8x37nx4s	128	19	RNAs	rna	NNS
cord-310192-8x37nx4s	128	20	.	.	.
cord-310192-8x37nx4s	129	1	However	however	RB
cord-310192-8x37nx4s	129	2	,	,	,
cord-310192-8x37nx4s	129	3	the	the	DT
cord-310192-8x37nx4s	129	4	ability	ability	NN
cord-310192-8x37nx4s	129	5	to	to	TO
cord-310192-8x37nx4s	129	6	incorporate	incorporate	VB
cord-310192-8x37nx4s	129	7	a	a	DT
cord-310192-8x37nx4s	129	8	labeled	label	VBN
cord-310192-8x37nx4s	129	9	nucleotide	nucleotide	NN
cord-310192-8x37nx4s	129	10	in	in	IN
cord-310192-8x37nx4s	129	11	a	a	DT
cord-310192-8x37nx4s	129	12	position	position	NN
cord-310192-8x37nx4s	129	13	-	-	HYPH
cord-310192-8x37nx4s	129	14	specific	specific	JJ
cord-310192-8x37nx4s	129	15	rather	rather	RB
cord-310192-8x37nx4s	129	16	than	than	IN
cord-310192-8x37nx4s	129	17	nucleotide	nucleotide	JJ
cord-310192-8x37nx4s	129	18	-	-	HYPH
cord-310192-8x37nx4s	129	19	specific	specific	JJ
cord-310192-8x37nx4s	129	20	manner	manner	NN
cord-310192-8x37nx4s	129	21	could	could	MD
cord-310192-8x37nx4s	129	22	also	also	RB
cord-310192-8x37nx4s	129	23	be	be	VB
cord-310192-8x37nx4s	129	24	advantageous	advantageous	JJ
cord-310192-8x37nx4s	129	25	.	.	.
cord-310192-8x37nx4s	130	1	Some	some	DT
cord-310192-8x37nx4s	130	2	complementary	complementary	JJ
cord-310192-8x37nx4s	130	3	biophysical	biophysical	JJ
cord-310192-8x37nx4s	130	4	techniques	technique	NNS
cord-310192-8x37nx4s	130	5	,	,	,
cord-310192-8x37nx4s	130	6	like	like	IN
cord-310192-8x37nx4s	130	7	fluorescence	fluorescence	NN
cord-310192-8x37nx4s	130	8	resonance	resonance	NN
cord-310192-8x37nx4s	130	9	energy	energy	NN
cord-310192-8x37nx4s	130	10	transfer	transfer	NN
cord-310192-8x37nx4s	130	11	and	and	CC
cord-310192-8x37nx4s	130	12	electron	electron	NN
cord-310192-8x37nx4s	130	13	paramagnetic	paramagnetic	JJ
cord-310192-8x37nx4s	130	14	resonance	resonance	NN
cord-310192-8x37nx4s	130	15	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	130	16	,	,	,
cord-310192-8x37nx4s	130	17	require	require	VBP
cord-310192-8x37nx4s	130	18	labeling	labeling	NN
cord-310192-8x37nx4s	130	19	at	at	IN
cord-310192-8x37nx4s	130	20	specific	specific	JJ
cord-310192-8x37nx4s	130	21	positions	position	NNS
cord-310192-8x37nx4s	130	22	rather	rather	RB
cord-310192-8x37nx4s	130	23	than	than	IN
cord-310192-8x37nx4s	130	24	uniformly	uniformly	RB
cord-310192-8x37nx4s	130	25	at	at	IN
cord-310192-8x37nx4s	130	26	a	a	DT
cord-310192-8x37nx4s	130	27	nucleotide	nucleotide	JJ
cord-310192-8x37nx4s	130	28	type	type	NN
cord-310192-8x37nx4s	130	29	throughout	throughout	IN
cord-310192-8x37nx4s	130	30	the	the	DT
cord-310192-8x37nx4s	130	31	whole	whole	JJ
cord-310192-8x37nx4s	130	32	molecule	molecule	NN
cord-310192-8x37nx4s	130	33	.	.	.
cord-310192-8x37nx4s	131	1	Chemical	chemical	JJ
cord-310192-8x37nx4s	131	2	synthesis	synthesis	NN
cord-310192-8x37nx4s	131	3	is	be	VBZ
cord-310192-8x37nx4s	131	4	commonly	commonly	RB
cord-310192-8x37nx4s	131	5	used	use	VBN
cord-310192-8x37nx4s	131	6	to	to	TO
cord-310192-8x37nx4s	131	7	make	make	VB
cord-310192-8x37nx4s	131	8	RNAs	rna	NNS
cord-310192-8x37nx4s	131	9	with	with	IN
cord-310192-8x37nx4s	131	10	position	position	NN
cord-310192-8x37nx4s	131	11	-	-	HYPH
cord-310192-8x37nx4s	131	12	specific	specific	JJ
cord-310192-8x37nx4s	131	13	labeling	labeling	NN
cord-310192-8x37nx4s	131	14	;	;	:
cord-310192-8x37nx4s	131	15	however	however	RB
cord-310192-8x37nx4s	131	16	,	,	,
cord-310192-8x37nx4s	131	17	it	-PRON-	PRP
cord-310192-8x37nx4s	131	18	is	be	VBZ
cord-310192-8x37nx4s	131	19	generally	generally	RB
cord-310192-8x37nx4s	131	20	limited	limit	VBN
cord-310192-8x37nx4s	131	21	to	to	IN
cord-310192-8x37nx4s	131	22	relatively	relatively	RB
cord-310192-8x37nx4s	131	23	small	small	JJ
cord-310192-8x37nx4s	131	24	RNAs	rna	NNS
cord-310192-8x37nx4s	131	25	(	(	-LRB-
cord-310192-8x37nx4s	131	26	<	<	NNP
cord-310192-8x37nx4s	131	27	60	60	CD
cord-310192-8x37nx4s	131	28	nt	nt	NN
cord-310192-8x37nx4s	131	29	)	)	-RRB-
cord-310192-8x37nx4s	131	30	(	(	-LRB-
cord-310192-8x37nx4s	131	31	Paredes	Paredes	NNP
cord-310192-8x37nx4s	131	32	,	,	,
cord-310192-8x37nx4s	131	33	Evans	Evans	NNP
cord-310192-8x37nx4s	131	34	,	,	,
cord-310192-8x37nx4s	131	35	&	&	CC
cord-310192-8x37nx4s	131	36	Das	Das	NNP
cord-310192-8x37nx4s	131	37	,	,	,
cord-310192-8x37nx4s	131	38	2011	2011	CD
cord-310192-8x37nx4s	131	39	)	)	-RRB-
cord-310192-8x37nx4s	131	40	.	.	.
cord-310192-8x37nx4s	132	1	It	-PRON-	PRP
cord-310192-8x37nx4s	132	2	is	be	VBZ
cord-310192-8x37nx4s	132	3	possible	possible	JJ
cord-310192-8x37nx4s	132	4	to	to	TO
cord-310192-8x37nx4s	132	5	enzymatically	enzymatically	RB
cord-310192-8x37nx4s	132	6	ligate	ligate	VB
cord-310192-8x37nx4s	132	7	several	several	JJ
cord-310192-8x37nx4s	132	8	smaller	small	JJR
cord-310192-8x37nx4s	132	9	synthetic	synthetic	JJ
cord-310192-8x37nx4s	132	10	RNAs	rna	NNS
cord-310192-8x37nx4s	132	11	together	together	RB
cord-310192-8x37nx4s	132	12	;	;	:
cord-310192-8x37nx4s	132	13	however	however	RB
cord-310192-8x37nx4s	132	14	,	,	,
cord-310192-8x37nx4s	132	15	the	the	DT
cord-310192-8x37nx4s	132	16	low	low	JJ
cord-310192-8x37nx4s	132	17	efficiency	efficiency	NN
cord-310192-8x37nx4s	132	18	of	of	IN
cord-310192-8x37nx4s	132	19	the	the	DT
cord-310192-8x37nx4s	132	20	ligation	ligation	NN
cord-310192-8x37nx4s	132	21	reactions	reaction	NNS
cord-310192-8x37nx4s	132	22	limits	limit	VBZ
cord-310192-8x37nx4s	132	23	the	the	DT
cord-310192-8x37nx4s	132	24	overall	overall	JJ
cord-310192-8x37nx4s	132	25	yield	yield	NN
cord-310192-8x37nx4s	132	26	of	of	IN
cord-310192-8x37nx4s	132	27	full	full	JJ
cord-310192-8x37nx4s	132	28	-	-	HYPH
cord-310192-8x37nx4s	132	29	length	length	NN
cord-310192-8x37nx4s	132	30	product	product	NN
cord-310192-8x37nx4s	132	31	.	.	.
cord-310192-8x37nx4s	133	1	In	in	IN
cord-310192-8x37nx4s	133	2	order	order	NN
cord-310192-8x37nx4s	133	3	to	to	TO
cord-310192-8x37nx4s	133	4	circumvent	circumvent	VB
cord-310192-8x37nx4s	133	5	these	these	DT
cord-310192-8x37nx4s	133	6	issues	issue	NNS
cord-310192-8x37nx4s	133	7	,	,	,
cord-310192-8x37nx4s	133	8	the	the	DT
cord-310192-8x37nx4s	133	9	Wang	Wang	NNP
cord-310192-8x37nx4s	133	10	lab	lab	NN
cord-310192-8x37nx4s	133	11	developed	develop	VBD
cord-310192-8x37nx4s	133	12	a	a	DT
cord-310192-8x37nx4s	133	13	hybrid	hybrid	JJ
cord-310192-8x37nx4s	133	14	solid	solid	JJ
cord-310192-8x37nx4s	133	15	-	-	HYPH
cord-310192-8x37nx4s	133	16	solution	solution	NN
cord-310192-8x37nx4s	133	17	phase	phase	NN
cord-310192-8x37nx4s	133	18	transcription	transcription	NN
cord-310192-8x37nx4s	133	19	method	method	NN
cord-310192-8x37nx4s	133	20	,	,	,
cord-310192-8x37nx4s	133	21	position	position	NN
cord-310192-8x37nx4s	133	22	-	-	HYPH
cord-310192-8x37nx4s	133	23	selective	selective	JJ
cord-310192-8x37nx4s	133	24	labeling	labeling	NN
cord-310192-8x37nx4s	133	25	of	of	IN
cord-310192-8x37nx4s	133	26	RNA	RNA	NNP
cord-310192-8x37nx4s	133	27	(	(	-LRB-
cord-310192-8x37nx4s	133	28	PLOR	PLOR	NNP
cord-310192-8x37nx4s	133	29	)	)	-RRB-
cord-310192-8x37nx4s	133	30	,	,	,
cord-310192-8x37nx4s	133	31	that	that	WDT
cord-310192-8x37nx4s	133	32	can	can	MD
cord-310192-8x37nx4s	133	33	theoretically	theoretically	RB
cord-310192-8x37nx4s	133	34	synthesize	synthesize	VB
cord-310192-8x37nx4s	133	35	any	any	DT
cord-310192-8x37nx4s	133	36	RNA	RNA	NNP
cord-310192-8x37nx4s	133	37	with	with	IN
cord-310192-8x37nx4s	133	38	labeling	labeling	NN
cord-310192-8x37nx4s	133	39	at	at	IN
cord-310192-8x37nx4s	133	40	any	any	DT
cord-310192-8x37nx4s	133	41	specific	specific	JJ
cord-310192-8x37nx4s	133	42	position	position	NN
cord-310192-8x37nx4s	133	43	using	use	VBG
cord-310192-8x37nx4s	133	44	commercially	commercially	RB
cord-310192-8x37nx4s	133	45	available	available	JJ
cord-310192-8x37nx4s	133	46	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	133	47	(	(	-LRB-
cord-310192-8x37nx4s	133	48	Liu	Liu	NNP
cord-310192-8x37nx4s	133	49	et	et	NNP
cord-310192-8x37nx4s	133	50	al	al	NNP
cord-310192-8x37nx4s	133	51	.	.	NNP
cord-310192-8x37nx4s	133	52	,	,	,
cord-310192-8x37nx4s	133	53	2015	2015	CD
cord-310192-8x37nx4s	134	1	(	(	-LRB-
cord-310192-8x37nx4s	134	2	Liu	Liu	NNP
cord-310192-8x37nx4s	134	3	et	et	NNP
cord-310192-8x37nx4s	134	4	al	al	NNP
cord-310192-8x37nx4s	134	5	.	.	.
cord-310192-8x37nx4s	135	1	,	,	,
cord-310192-8x37nx4s	135	2	,	,	,
cord-310192-8x37nx4s	135	3	2016	2016	CD
cord-310192-8x37nx4s	135	4	.	.	.
cord-310192-8x37nx4s	136	1	The	the	DT
cord-310192-8x37nx4s	136	2	biggest	big	JJS
cord-310192-8x37nx4s	136	3	advantage	advantage	NN
cord-310192-8x37nx4s	136	4	of	of	IN
cord-310192-8x37nx4s	136	5	this	this	DT
cord-310192-8x37nx4s	136	6	approach	approach	NN
cord-310192-8x37nx4s	136	7	over	over	IN
cord-310192-8x37nx4s	136	8	other	other	JJ
cord-310192-8x37nx4s	136	9	methods	method	NNS
cord-310192-8x37nx4s	136	10	is	be	VBZ
cord-310192-8x37nx4s	136	11	that	that	IN
cord-310192-8x37nx4s	136	12	it	-PRON-	PRP
cord-310192-8x37nx4s	136	13	can	can	MD
cord-310192-8x37nx4s	136	14	prepare	prepare	VB
cord-310192-8x37nx4s	136	15	large	large	JJ
cord-310192-8x37nx4s	136	16	selectively	selectively	RB
cord-310192-8x37nx4s	136	17	labeled	label	VBN
cord-310192-8x37nx4s	136	18	RNA	RNA	NNP
cord-310192-8x37nx4s	136	19	samples	sample	NNS
cord-310192-8x37nx4s	136	20	at	at	IN
cord-310192-8x37nx4s	136	21	a	a	DT
cord-310192-8x37nx4s	136	22	scale	scale	NN
cord-310192-8x37nx4s	136	23	appropriate	appropriate	JJ
cord-310192-8x37nx4s	136	24	for	for	IN
cord-310192-8x37nx4s	136	25	NMR	NMR	NNP
cord-310192-8x37nx4s	136	26	studies	study	NNS
cord-310192-8x37nx4s	136	27	(	(	-LRB-
cord-310192-8x37nx4s	137	1	Liu	Liu	NNP
cord-310192-8x37nx4s	137	2	et	et	NNP
cord-310192-8x37nx4s	137	3	al	al	NNP
cord-310192-8x37nx4s	137	4	.	.	NNP
cord-310192-8x37nx4s	137	5	,	,	,
cord-310192-8x37nx4s	137	6	2016	2016	CD
cord-310192-8x37nx4s	137	7	)	)	-RRB-
cord-310192-8x37nx4s	137	8	.	.	.
cord-310192-8x37nx4s	138	1	The	the	DT
cord-310192-8x37nx4s	138	2	use	use	NN
cord-310192-8x37nx4s	138	3	of	of	IN
cord-310192-8x37nx4s	138	4	PLOR	PLOR	NNP
cord-310192-8x37nx4s	138	5	to	to	IN
cord-310192-8x37nx4s	138	6	position	position	VB
cord-310192-8x37nx4s	138	7	-	-	:
cord-310192-8x37nx4s	138	8	specifically	specifically	RB
cord-310192-8x37nx4s	138	9	incorporate	incorporate	VB
cord-310192-8x37nx4s	138	10	a	a	DT
cord-310192-8x37nx4s	138	11	labeled	label	VBN
cord-310192-8x37nx4s	138	12	nucleotide	nucleotide	NN
cord-310192-8x37nx4s	138	13	into	into	IN
cord-310192-8x37nx4s	138	14	a	a	DT
cord-310192-8x37nx4s	138	15	large	large	JJ
cord-310192-8x37nx4s	138	16	RNA	RNA	NNP
cord-310192-8x37nx4s	138	17	has	have	VBZ
cord-310192-8x37nx4s	138	18	many	many	JJ
cord-310192-8x37nx4s	138	19	potential	potential	JJ
cord-310192-8x37nx4s	138	20	benefits	benefit	NNS
cord-310192-8x37nx4s	138	21	including	include	VBG
cord-310192-8x37nx4s	138	22	breaking	break	VBG
cord-310192-8x37nx4s	138	23	ambiguity	ambiguity	NN
cord-310192-8x37nx4s	138	24	in	in	IN
cord-310192-8x37nx4s	138	25	resonance	resonance	NN
cord-310192-8x37nx4s	138	26	assignments	assignment	NNS
cord-310192-8x37nx4s	138	27	and	and	CC
cord-310192-8x37nx4s	138	28	facilitating	facilitate	VBG
cord-310192-8x37nx4s	138	29	the	the	DT
cord-310192-8x37nx4s	138	30	identification	identification	NN
cord-310192-8x37nx4s	138	31	of	of	IN
cord-310192-8x37nx4s	138	32	long	long	JJ
cord-310192-8x37nx4s	138	33	-	-	HYPH
cord-310192-8x37nx4s	138	34	range	range	NN
cord-310192-8x37nx4s	138	35	interactions	interaction	NNS
cord-310192-8x37nx4s	138	36	.	.	.
cord-310192-8x37nx4s	139	1	A	a	DT
cord-310192-8x37nx4s	139	2	very	very	RB
cord-310192-8x37nx4s	139	3	common	common	JJ
cord-310192-8x37nx4s	139	4	approach	approach	NN
cord-310192-8x37nx4s	139	5	to	to	IN
cord-310192-8x37nx4s	139	6	tackling	tackle	VBG
cord-310192-8x37nx4s	139	7	resonance	resonance	NN
cord-310192-8x37nx4s	139	8	assignments	assignment	NNS
cord-310192-8x37nx4s	139	9	of	of	IN
cord-310192-8x37nx4s	139	10	large	large	JJ
cord-310192-8x37nx4s	139	11	RNAs	rna	NNS
cord-310192-8x37nx4s	139	12	is	be	VBZ
cord-310192-8x37nx4s	139	13	a	a	DT
cord-310192-8x37nx4s	139	14	"	"	``
cord-310192-8x37nx4s	139	15	divide	divide	NN
cord-310192-8x37nx4s	139	16	and	and	CC
cord-310192-8x37nx4s	139	17	conquer	conquer	VB
cord-310192-8x37nx4s	139	18	"	"	''
cord-310192-8x37nx4s	139	19	strategy	strategy	NN
cord-310192-8x37nx4s	139	20	,	,	,
cord-310192-8x37nx4s	139	21	where	where	WRB
cord-310192-8x37nx4s	139	22	the	the	DT
cord-310192-8x37nx4s	139	23	large	large	JJ
cord-310192-8x37nx4s	139	24	RNA	RNA	NNP
cord-310192-8x37nx4s	139	25	(	(	-LRB-
cord-310192-8x37nx4s	139	26	Figure	figure	NN
cord-310192-8x37nx4s	139	27	3a	3a	CD
cord-310192-8x37nx4s	139	28	)	)	-RRB-
cord-310192-8x37nx4s	139	29	is	be	VBZ
cord-310192-8x37nx4s	139	30	broken	break	VBN
cord-310192-8x37nx4s	139	31	down	down	RP
cord-310192-8x37nx4s	139	32	into	into	IN
cord-310192-8x37nx4s	139	33	individual	individual	JJ
cord-310192-8x37nx4s	139	34	folded	fold	VBN
cord-310192-8x37nx4s	139	35	domains	domain	NNS
cord-310192-8x37nx4s	139	36	(	(	-LRB-
cord-310192-8x37nx4s	139	37	Figure	figure	NN
cord-310192-8x37nx4s	139	38	3b	3b	CD
cord-310192-8x37nx4s	139	39	)	)	-RRB-
cord-310192-8x37nx4s	140	1	(	(	-LRB-
cord-310192-8x37nx4s	140	2	Imai	Imai	NNP
cord-310192-8x37nx4s	140	3	et	et	NNP
cord-310192-8x37nx4s	140	4	al	al	NNP
cord-310192-8x37nx4s	140	5	.	.	NNP
cord-310192-8x37nx4s	140	6	,	,	,
cord-310192-8x37nx4s	140	7	2016	2016	CD
cord-310192-8x37nx4s	141	1	;	;	:
cord-310192-8x37nx4s	141	2	Keane	Keane	NNP
cord-310192-8x37nx4s	141	3	et	et	NNP
cord-310192-8x37nx4s	141	4	al	al	NNP
cord-310192-8x37nx4s	141	5	.	.	NNP
cord-310192-8x37nx4s	141	6	,	,	,
cord-310192-8x37nx4s	141	7	2015	2015	CD
cord-310192-8x37nx4s	141	8	;	;	:
cord-310192-8x37nx4s	141	9	 	 	_SP
cord-310192-8x37nx4s	141	10	Ziegeler	Ziegeler	NNP
cord-310192-8x37nx4s	141	11	,	,	,
cord-310192-8x37nx4s	141	12	Cevec	Cevec	NNP
cord-310192-8x37nx4s	141	13	,	,	,
cord-310192-8x37nx4s	141	14	Richter	Richter	NNP
cord-310192-8x37nx4s	141	15	,	,	,
cord-310192-8x37nx4s	141	16	&	&	CC
cord-310192-8x37nx4s	141	17	Schwalbe	Schwalbe	NNP
cord-310192-8x37nx4s	141	18	,	,	,
cord-310192-8x37nx4s	141	19	2012	2012	CD
cord-310192-8x37nx4s	141	20	)	)	-RRB-
cord-310192-8x37nx4s	141	21	.	.	.
cord-310192-8x37nx4s	142	1	These	these	DT
cord-310192-8x37nx4s	142	2	small	small	JJ
cord-310192-8x37nx4s	142	3	,	,	,
cord-310192-8x37nx4s	142	4	individual	individual	JJ
cord-310192-8x37nx4s	142	5	domains	domain	NNS
cord-310192-8x37nx4s	142	6	are	be	VBP
cord-310192-8x37nx4s	142	7	amenable	amenable	JJ
cord-310192-8x37nx4s	142	8	to	to	IN
cord-310192-8x37nx4s	142	9	rapid	rapid	JJ
cord-310192-8x37nx4s	142	10	data	datum	NNS
cord-310192-8x37nx4s	142	11	collection	collection	NN
cord-310192-8x37nx4s	142	12	and	and	CC
cord-310192-8x37nx4s	142	13	resonance	resonance	NN
cord-310192-8x37nx4s	142	14	assignment	assignment	NN
cord-310192-8x37nx4s	142	15	.	.	.
cord-310192-8x37nx4s	143	1	The	the	DT
cord-310192-8x37nx4s	143	2	assignment	assignment	NN
cord-310192-8x37nx4s	143	3	data	datum	NNS
cord-310192-8x37nx4s	143	4	can	can	MD
cord-310192-8x37nx4s	143	5	then	then	RB
cord-310192-8x37nx4s	143	6	be	be	VB
cord-310192-8x37nx4s	143	7	"	"	``
cord-310192-8x37nx4s	143	8	grafted	graft	VBN
cord-310192-8x37nx4s	143	9	"	"	''
cord-310192-8x37nx4s	143	10	to	to	IN
cord-310192-8x37nx4s	143	11	the	the	DT
cord-310192-8x37nx4s	143	12	full	full	JJ
cord-310192-8x37nx4s	143	13	-	-	HYPH
cord-310192-8x37nx4s	143	14	length	length	NN
cord-310192-8x37nx4s	143	15	data	datum	NNS
cord-310192-8x37nx4s	143	16	to	to	TO
cord-310192-8x37nx4s	143	17	help	help	VB
cord-310192-8x37nx4s	143	18	deconvolute	deconvolute	VB
cord-310192-8x37nx4s	143	19	the	the	DT
cord-310192-8x37nx4s	143	20	more	more	RBR
cord-310192-8x37nx4s	143	21	complicated	complicated	JJ
cord-310192-8x37nx4s	143	22	data	datum	NNS
cord-310192-8x37nx4s	143	23	.	.	.
cord-310192-8x37nx4s	144	1	While	while	IN
cord-310192-8x37nx4s	144	2	this	this	DT
cord-310192-8x37nx4s	144	3	approach	approach	NN
cord-310192-8x37nx4s	144	4	works	work	VBZ
cord-310192-8x37nx4s	144	5	in	in	IN
cord-310192-8x37nx4s	144	6	many	many	JJ
cord-310192-8x37nx4s	144	7	situations	situation	NNS
cord-310192-8x37nx4s	144	8	,	,	,
cord-310192-8x37nx4s	144	9	it	-PRON-	PRP
cord-310192-8x37nx4s	144	10	is	be	VBZ
cord-310192-8x37nx4s	144	11	dependent	dependent	JJ
cord-310192-8x37nx4s	144	12	on	on	IN
cord-310192-8x37nx4s	144	13	the	the	DT
cord-310192-8x37nx4s	144	14	fragments	fragment	NNS
cord-310192-8x37nx4s	144	15	adopting	adopt	VBG
cord-310192-8x37nx4s	144	16	the	the	DT
cord-310192-8x37nx4s	144	17	same	same	JJ
cord-310192-8x37nx4s	144	18	structure	structure	NN
cord-310192-8x37nx4s	144	19	in	in	IN
cord-310192-8x37nx4s	144	20	isolation	isolation	NN
cord-310192-8x37nx4s	144	21	as	as	IN
cord-310192-8x37nx4s	144	22	they	-PRON-	PRP
cord-310192-8x37nx4s	144	23	do	do	VBP
cord-310192-8x37nx4s	144	24	in	in	IN
cord-310192-8x37nx4s	144	25	the	the	DT
cord-310192-8x37nx4s	144	26	full	full	JJ
cord-310192-8x37nx4s	144	27	-	-	HYPH
cord-310192-8x37nx4s	144	28	length	length	NN
cord-310192-8x37nx4s	144	29	construct	construct	NN
cord-310192-8x37nx4s	144	30	.	.	.
cord-310192-8x37nx4s	145	1	It	-PRON-	PRP
cord-310192-8x37nx4s	145	2	is	be	VBZ
cord-310192-8x37nx4s	145	3	possible	possible	JJ
cord-310192-8x37nx4s	145	4	for	for	IN
cord-310192-8x37nx4s	145	5	the	the	DT
cord-310192-8x37nx4s	145	6	fragments	fragment	NNS
cord-310192-8x37nx4s	145	7	to	to	TO
cord-310192-8x37nx4s	145	8	not	not	RB
cord-310192-8x37nx4s	145	9	fold	fold	VB
cord-310192-8x37nx4s	145	10	properly	properly	RB
cord-310192-8x37nx4s	145	11	,	,	,
cord-310192-8x37nx4s	145	12	or	or	CC
cord-310192-8x37nx4s	145	13	to	to	TO
cord-310192-8x37nx4s	145	14	be	be	VB
cord-310192-8x37nx4s	145	15	poor	poor	JJ
cord-310192-8x37nx4s	145	16	representations	representation	NNS
cord-310192-8x37nx4s	145	17	of	of	IN
cord-310192-8x37nx4s	145	18	the	the	DT
cord-310192-8x37nx4s	145	19	region	region	NN
cord-310192-8x37nx4s	145	20	in	in	IN
cord-310192-8x37nx4s	145	21	the	the	DT
cord-310192-8x37nx4s	145	22	larger	large	JJR
cord-310192-8x37nx4s	145	23	context	context	NN
cord-310192-8x37nx4s	145	24	.	.	.
cord-310192-8x37nx4s	146	1	However	however	RB
cord-310192-8x37nx4s	146	2	,	,	,
cord-310192-8x37nx4s	146	3	we	-PRON-	PRP
cord-310192-8x37nx4s	146	4	generally	generally	RB
cord-310192-8x37nx4s	146	5	find	find	VBP
cord-310192-8x37nx4s	146	6	this	this	DT
cord-310192-8x37nx4s	146	7	approach	approach	NN
cord-310192-8x37nx4s	146	8	exceptionally	exceptionally	RB
cord-310192-8x37nx4s	146	9	helpful	helpful	JJ
cord-310192-8x37nx4s	146	10	in	in	IN
cord-310192-8x37nx4s	146	11	the	the	DT
cord-310192-8x37nx4s	146	12	early	early	JJ
cord-310192-8x37nx4s	146	13	stages	stage	NNS
cord-310192-8x37nx4s	146	14	of	of	IN
cord-310192-8x37nx4s	146	15	fulllength	fulllength	NN
cord-310192-8x37nx4s	146	16	resonance	resonance	NN
cord-310192-8x37nx4s	146	17	assignments	assignment	NNS
cord-310192-8x37nx4s	146	18	.	.	.
cord-310192-8x37nx4s	147	1	Another	another	DT
cord-310192-8x37nx4s	147	2	approach	approach	NN
cord-310192-8x37nx4s	147	3	that	that	WDT
cord-310192-8x37nx4s	147	4	is	be	VBZ
cord-310192-8x37nx4s	147	5	widely	widely	RB
cord-310192-8x37nx4s	147	6	used	use	VBN
cord-310192-8x37nx4s	147	7	is	be	VBZ
cord-310192-8x37nx4s	147	8	an	an	DT
cord-310192-8x37nx4s	147	9	enzymatic	enzymatic	JJ
cord-310192-8x37nx4s	147	10	ligation	ligation	NN
cord-310192-8x37nx4s	147	11	approach	approach	NN
cord-310192-8x37nx4s	147	12	using	use	VBG
cord-310192-8x37nx4s	147	13	either	either	CC
cord-310192-8x37nx4s	147	14	T4	T4	NNP
cord-310192-8x37nx4s	147	15	DNA	DNA	NNP
cord-310192-8x37nx4s	147	16	or	or	CC
cord-310192-8x37nx4s	147	17	RNA	RNA	NNP
cord-310192-8x37nx4s	147	18	ligase	ligase	NN
cord-310192-8x37nx4s	147	19	to	to	TO
cord-310192-8x37nx4s	147	20	join	join	VB
cord-310192-8x37nx4s	147	21	either	either	CC
cord-310192-8x37nx4s	147	22	chemically	chemically	RB
cord-310192-8x37nx4s	147	23	synthesized	synthesize	VBN
cord-310192-8x37nx4s	147	24	or	or	CC
cord-310192-8x37nx4s	147	25	in	in	IN
cord-310192-8x37nx4s	147	26	vitro	vitro	FW
cord-310192-8x37nx4s	147	27	transcribed	transcribe	VBN
cord-310192-8x37nx4s	147	28	RNAs	rna	NNS
cord-310192-8x37nx4s	147	29	with	with	IN
cord-310192-8x37nx4s	147	30	different	different	JJ
cord-310192-8x37nx4s	147	31	labeling	labeling	NN
cord-310192-8x37nx4s	147	32	strategies	strategy	NNS
cord-310192-8x37nx4s	147	33	(	(	-LRB-
cord-310192-8x37nx4s	147	34	Figure	figure	NN
cord-310192-8x37nx4s	147	35	3c	3c	CD
cord-310192-8x37nx4s	147	36	)	)	-RRB-
cord-310192-8x37nx4s	148	1	(	(	-LRB-
cord-310192-8x37nx4s	148	2	Duss	Duss	NNP
cord-310192-8x37nx4s	148	3	,	,	,
cord-310192-8x37nx4s	148	4	Maris	Maris	NNP
cord-310192-8x37nx4s	148	5	,	,	,
cord-310192-8x37nx4s	148	6	von	von	NNP
cord-310192-8x37nx4s	148	7	Schroetter	Schroetter	NNP
cord-310192-8x37nx4s	148	8	,	,	,
cord-310192-8x37nx4s	148	9	&	&	CC
cord-310192-8x37nx4s	148	10	Allain	Allain	NNP
cord-310192-8x37nx4s	148	11	,	,	,
cord-310192-8x37nx4s	148	12	2010	2010	CD
cord-310192-8x37nx4s	148	13	;	;	:
cord-310192-8x37nx4s	148	14	I.	I.	NNP
cord-310192-8x37nx4s	148	15	Kim	Kim	NNP
cord-310192-8x37nx4s	148	16	,	,	,
cord-310192-8x37nx4s	148	17	Lukavsky	Lukavsky	NNP
cord-310192-8x37nx4s	148	18	,	,	,
cord-310192-8x37nx4s	148	19	&	&	CC
cord-310192-8x37nx4s	148	20	Puglisi	Puglisi	NNP
cord-310192-8x37nx4s	148	21	,	,	,
cord-310192-8x37nx4s	148	22	2002	2002	CD
cord-310192-8x37nx4s	148	23	;	;	:
cord-310192-8x37nx4s	148	24	Lu	Lu	NNP
cord-310192-8x37nx4s	148	25	et	et	FW
cord-310192-8x37nx4s	148	26	al	al	NNP
cord-310192-8x37nx4s	148	27	.	.	.
cord-310192-8x37nx4s	149	1	,	,	,
cord-310192-8x37nx4s	149	2	2011	2011	CD
cord-310192-8x37nx4s	149	3	;	;	:
cord-310192-8x37nx4s	149	4	Nelissen	Nelissen	NNP
cord-310192-8x37nx4s	149	5	et	et	FW
cord-310192-8x37nx4s	149	6	al	al	NNP
cord-310192-8x37nx4s	149	7	.	.	NNP
cord-310192-8x37nx4s	149	8	,	,	,
cord-310192-8x37nx4s	149	9	2008	2008	CD
cord-310192-8x37nx4s	149	10	;	;	:
cord-310192-8x37nx4s	149	11	Tzakos	Tzakos	NNP
cord-310192-8x37nx4s	149	12	,	,	,
cord-310192-8x37nx4s	149	13	Easton	Easton	NNP
cord-310192-8x37nx4s	149	14	,	,	,
cord-310192-8x37nx4s	149	15	&	&	CC
cord-310192-8x37nx4s	149	16	Lukavsky	Lukavsky	NNP
cord-310192-8x37nx4s	149	17	,	,	,
cord-310192-8x37nx4s	149	18	2007	2007	CD
cord-310192-8x37nx4s	149	19	;	;	:
cord-310192-8x37nx4s	149	20	Xu	Xu	NNP
cord-310192-8x37nx4s	149	21	,	,	,
cord-310192-8x37nx4s	149	22	Lapham	Lapham	NNP
cord-310192-8x37nx4s	149	23	,	,	,
cord-310192-8x37nx4s	149	24	&	&	CC
cord-310192-8x37nx4s	149	25	Crothers	Crothers	NNPS
cord-310192-8x37nx4s	149	26	,	,	,
cord-310192-8x37nx4s	149	27	1996	1996	CD
cord-310192-8x37nx4s	149	28	)	)	-RRB-
cord-310192-8x37nx4s	149	29	.	.	.
cord-310192-8x37nx4s	150	1	These	these	DT
cord-310192-8x37nx4s	150	2	methods	method	NNS
cord-310192-8x37nx4s	150	3	require	require	VBP
cord-310192-8x37nx4s	150	4	extensive	extensive	JJ
cord-310192-8x37nx4s	150	5	optimization	optimization	NN
cord-310192-8x37nx4s	150	6	and	and	CC
cord-310192-8x37nx4s	150	7	troubleshooting	troubleshooting	NN
cord-310192-8x37nx4s	150	8	and	and	CC
cord-310192-8x37nx4s	150	9	are	be	VBP
cord-310192-8x37nx4s	150	10	notorious	notorious	JJ
cord-310192-8x37nx4s	150	11	for	for	IN
cord-310192-8x37nx4s	150	12	low	low	JJ
cord-310192-8x37nx4s	150	13	yield	yield	NN
cord-310192-8x37nx4s	150	14	of	of	IN
cord-310192-8x37nx4s	150	15	product	product	NN
cord-310192-8x37nx4s	150	16	,	,	,
cord-310192-8x37nx4s	150	17	although	although	IN
cord-310192-8x37nx4s	150	18	significant	significant	JJ
cord-310192-8x37nx4s	150	19	improvements	improvement	NNS
cord-310192-8x37nx4s	150	20	have	have	VBP
cord-310192-8x37nx4s	150	21	been	be	VBN
cord-310192-8x37nx4s	150	22	made	make	VBN
cord-310192-8x37nx4s	150	23	to	to	TO
cord-310192-8x37nx4s	150	24	improve	improve	VB
cord-310192-8x37nx4s	150	25	the	the	DT
cord-310192-8x37nx4s	150	26	yield	yield	NN
cord-310192-8x37nx4s	150	27	,	,	,
cord-310192-8x37nx4s	150	28	eliminate	eliminate	VB
cord-310192-8x37nx4s	150	29	specific	specific	JJ
cord-310192-8x37nx4s	150	30	sequence	sequence	NN
cord-310192-8x37nx4s	150	31	requirements	requirement	NNS
cord-310192-8x37nx4s	150	32	,	,	,
cord-310192-8x37nx4s	150	33	and	and	CC
cord-310192-8x37nx4s	150	34	streamline	streamline	VB
cord-310192-8x37nx4s	150	35	the	the	DT
cord-310192-8x37nx4s	150	36	process	process	NN
cord-310192-8x37nx4s	150	37	(	(	-LRB-
cord-310192-8x37nx4s	150	38	Duss	Duss	NNP
cord-310192-8x37nx4s	150	39	et	et	FW
cord-310192-8x37nx4s	150	40	al	al	NNP
cord-310192-8x37nx4s	150	41	.	.	NNP
cord-310192-8x37nx4s	150	42	,	,	,
cord-310192-8x37nx4s	150	43	2010	2010	CD
cord-310192-8x37nx4s	150	44	)	)	-RRB-
cord-310192-8x37nx4s	150	45	.	.	.
cord-310192-8x37nx4s	151	1	The	the	DT
cord-310192-8x37nx4s	151	2	Allain	Allain	NNP
cord-310192-8x37nx4s	151	3	lab	lab	NN
cord-310192-8x37nx4s	151	4	developed	develop	VBD
cord-310192-8x37nx4s	151	5	a	a	DT
cord-310192-8x37nx4s	151	6	robust	robust	JJ
cord-310192-8x37nx4s	151	7	and	and	CC
cord-310192-8x37nx4s	151	8	versatile	versatile	JJ
cord-310192-8x37nx4s	151	9	segmental	segmental	JJ
cord-310192-8x37nx4s	151	10	labeling	labeling	NN
cord-310192-8x37nx4s	151	11	method	method	NN
cord-310192-8x37nx4s	151	12	that	that	WDT
cord-310192-8x37nx4s	151	13	uses	use	VBZ
cord-310192-8x37nx4s	151	14	ribozymes	ribozyme	NNS
cord-310192-8x37nx4s	151	15	and	and	CC
cord-310192-8x37nx4s	151	16	RNaseH	rnaseh	JJ
cord-310192-8x37nx4s	151	17	cleavage	cleavage	NN
cord-310192-8x37nx4s	151	18	to	to	TO
cord-310192-8x37nx4s	151	19	generate	generate	VB
cord-310192-8x37nx4s	151	20	fragments	fragment	NNS
cord-310192-8x37nx4s	151	21	of	of	IN
cord-310192-8x37nx4s	151	22	RNA	RNA	NNP
cord-310192-8x37nx4s	151	23	for	for	IN
cord-310192-8x37nx4s	151	24	subsequent	subsequent	JJ
cord-310192-8x37nx4s	151	25	ligation	ligation	NN
cord-310192-8x37nx4s	151	26	.	.	.
cord-310192-8x37nx4s	152	1	This	this	DT
cord-310192-8x37nx4s	152	2	approach	approach	NN
cord-310192-8x37nx4s	152	3	was	be	VBD
cord-310192-8x37nx4s	152	4	demonstrated	demonstrate	VBN
cord-310192-8x37nx4s	152	5	on	on	IN
cord-310192-8x37nx4s	152	6	the	the	DT
cord-310192-8x37nx4s	152	7	72	72	CD
cord-310192-8x37nx4s	152	8	nucleotide	nucleotide	NN
cord-310192-8x37nx4s	152	9	RsmZ	RsmZ	NNP
cord-310192-8x37nx4s	152	10	RNA	RNA	NNP
cord-310192-8x37nx4s	152	11	,	,	,
cord-310192-8x37nx4s	152	12	which	which	WDT
cord-310192-8x37nx4s	152	13	was	be	VBD
cord-310192-8x37nx4s	152	14	fragmented	fragment	VBN
cord-310192-8x37nx4s	152	15	into	into	IN
cord-310192-8x37nx4s	152	16	four	four	CD
cord-310192-8x37nx4s	152	17	components	component	NNS
cord-310192-8x37nx4s	152	18	for	for	IN
cord-310192-8x37nx4s	152	19	reassembly	reassembly	NN
cord-310192-8x37nx4s	152	20	in	in	IN
cord-310192-8x37nx4s	152	21	NMR	NMR	NNP
cord-310192-8x37nx4s	152	22	spectral	spectral	JJ
cord-310192-8x37nx4s	152	23	analysis	analysis	NN
cord-310192-8x37nx4s	153	1	(	(	-LRB-
cord-310192-8x37nx4s	153	2	Duss	Duss	NNP
cord-310192-8x37nx4s	153	3	et	et	FW
cord-310192-8x37nx4s	153	4	al	al	NNP
cord-310192-8x37nx4s	153	5	.	.	NNP
cord-310192-8x37nx4s	153	6	,	,	,
cord-310192-8x37nx4s	153	7	2010	2010	CD
cord-310192-8x37nx4s	153	8	)	)	-RRB-
cord-310192-8x37nx4s	153	9	.	.	.
cord-310192-8x37nx4s	154	1	This	this	DT
cord-310192-8x37nx4s	154	2	method	method	NN
cord-310192-8x37nx4s	154	3	offers	offer	VBZ
cord-310192-8x37nx4s	154	4	several	several	JJ
cord-310192-8x37nx4s	154	5	distinct	distinct	JJ
cord-310192-8x37nx4s	154	6	advantages	advantage	NNS
cord-310192-8x37nx4s	154	7	over	over	IN
cord-310192-8x37nx4s	154	8	other	other	JJ
cord-310192-8x37nx4s	154	9	methods	method	NNS
cord-310192-8x37nx4s	154	10	for	for	IN
cord-310192-8x37nx4s	154	11	segmental	segmental	JJ
cord-310192-8x37nx4s	154	12	labeling	labeling	NN
cord-310192-8x37nx4s	154	13	of	of	IN
cord-310192-8x37nx4s	154	14	RNAs	rna	NNS
cord-310192-8x37nx4s	154	15	.	.	.
cord-310192-8x37nx4s	155	1	First	first	RB
cord-310192-8x37nx4s	155	2	,	,	,
cord-310192-8x37nx4s	155	3	this	this	DT
cord-310192-8x37nx4s	155	4	method	method	NN
cord-310192-8x37nx4s	155	5	is	be	VBZ
cord-310192-8x37nx4s	155	6	flexible	flexible	JJ
cord-310192-8x37nx4s	155	7	-	-	HYPH
cord-310192-8x37nx4s	155	8	new	new	JJ
cord-310192-8x37nx4s	155	9	ligation	ligation	NN
cord-310192-8x37nx4s	155	10	sites	site	NNS
cord-310192-8x37nx4s	155	11	can	can	MD
cord-310192-8x37nx4s	155	12	be	be	VB
cord-310192-8x37nx4s	155	13	introduced	introduce	VBN
cord-310192-8x37nx4s	155	14	by	by	IN
cord-310192-8x37nx4s	155	15	performing	perform	VBG
cord-310192-8x37nx4s	155	16	the	the	DT
cord-310192-8x37nx4s	155	17	RNaseH	rnaseh	JJ
cord-310192-8x37nx4s	155	18	cleavage	cleavage	NN
cord-310192-8x37nx4s	155	19	with	with	IN
cord-310192-8x37nx4s	155	20	a	a	DT
cord-310192-8x37nx4s	155	21	new	new	JJ
cord-310192-8x37nx4s	155	22	splint	splint	NN
cord-310192-8x37nx4s	155	23	-	-	HYPH
cord-310192-8x37nx4s	155	24	directed	direct	VBN
cord-310192-8x37nx4s	155	25	site	site	NN
cord-310192-8x37nx4s	155	26	.	.	.
cord-310192-8x37nx4s	156	1	Second	second	RB
cord-310192-8x37nx4s	156	2	,	,	,
cord-310192-8x37nx4s	156	3	only	only	RB
cord-310192-8x37nx4s	156	4	two	two	CD
cord-310192-8x37nx4s	156	5	pools	pool	NNS
cord-310192-8x37nx4s	156	6	of	of	IN
cord-310192-8x37nx4s	156	7	full	full	JJ
cord-310192-8x37nx4s	156	8	-	-	HYPH
cord-310192-8x37nx4s	156	9	length	length	NN
cord-310192-8x37nx4s	156	10	RNA	RNA	NNP
cord-310192-8x37nx4s	156	11	,	,	,
cord-310192-8x37nx4s	156	12	isotopically	isotopically	RB
cord-310192-8x37nx4s	156	13	labeled	label	VBN
cord-310192-8x37nx4s	156	14	and	and	CC
cord-310192-8x37nx4s	156	15	unlabeled	unlabeled	JJ
cord-310192-8x37nx4s	156	16	,	,	,
cord-310192-8x37nx4s	156	17	are	be	VBP
cord-310192-8x37nx4s	156	18	neededcloning	neededclone	VBG
cord-310192-8x37nx4s	156	19	of	of	IN
cord-310192-8x37nx4s	156	20	subfragments	subfragment	NNS
cord-310192-8x37nx4s	156	21	is	be	VBZ
cord-310192-8x37nx4s	156	22	not	not	RB
cord-310192-8x37nx4s	156	23	necessary	necessary	JJ
cord-310192-8x37nx4s	156	24	.	.	.
cord-310192-8x37nx4s	157	1	Finally	finally	RB
cord-310192-8x37nx4s	157	2	,	,	,
cord-310192-8x37nx4s	157	3	the	the	DT
cord-310192-8x37nx4s	157	4	cleavage	cleavage	NN
cord-310192-8x37nx4s	157	5	and	and	CC
cord-310192-8x37nx4s	157	6	ligation	ligation	NN
cord-310192-8x37nx4s	157	7	strategy	strategy	NN
cord-310192-8x37nx4s	157	8	are	be	VBP
cord-310192-8x37nx4s	157	9	efficient	efficient	JJ
cord-310192-8x37nx4s	157	10	even	even	RB
cord-310192-8x37nx4s	157	11	for	for	IN
cord-310192-8x37nx4s	157	12	highly	highly	RB
cord-310192-8x37nx4s	157	13	structured	structured	JJ
cord-310192-8x37nx4s	157	14	RNAs	rna	NNS
cord-310192-8x37nx4s	157	15	,	,	,
cord-310192-8x37nx4s	157	16	making	make	VBG
cord-310192-8x37nx4s	157	17	this	this	DT
cord-310192-8x37nx4s	157	18	approach	approach	NN
cord-310192-8x37nx4s	157	19	virtually	virtually	RB
cord-310192-8x37nx4s	157	20	universal	universal	JJ
cord-310192-8x37nx4s	157	21	.	.	.
cord-310192-8x37nx4s	158	1	One	one	CD
cord-310192-8x37nx4s	158	2	alternative	alternative	NN
cord-310192-8x37nx4s	158	3	to	to	IN
cord-310192-8x37nx4s	158	4	traditional	traditional	JJ
cord-310192-8x37nx4s	158	5	enzymatic	enzymatic	RB
cord-310192-8x37nx4s	158	6	-	-	HYPH
cord-310192-8x37nx4s	158	7	based	base	VBN
cord-310192-8x37nx4s	158	8	segmental	segmental	JJ
cord-310192-8x37nx4s	158	9	labeling	labeling	NN
cord-310192-8x37nx4s	158	10	strategies	strategy	NNS
cord-310192-8x37nx4s	158	11	is	be	VBZ
cord-310192-8x37nx4s	158	12	a	a	DT
cord-310192-8x37nx4s	158	13	fragmentation	fragmentation	NN
cord-310192-8x37nx4s	158	14	-	-	HYPH
cord-310192-8x37nx4s	158	15	based	base	VBN
cord-310192-8x37nx4s	158	16	approach	approach	NN
cord-310192-8x37nx4s	158	17	that	that	WDT
cord-310192-8x37nx4s	158	18	relies	rely	VBZ
cord-310192-8x37nx4s	158	19	on	on	IN
cord-310192-8x37nx4s	158	20	annealing	anneal	VBG
cord-310192-8x37nx4s	158	21	rather	rather	RB
cord-310192-8x37nx4s	158	22	than	than	IN
cord-310192-8x37nx4s	158	23	ligation	ligation	NN
cord-310192-8x37nx4s	158	24	to	to	TO
cord-310192-8x37nx4s	158	25	join	join	VB
cord-310192-8x37nx4s	158	26	the	the	DT
cord-310192-8x37nx4s	158	27	fragments	fragment	NNS
cord-310192-8x37nx4s	158	28	together	together	RB
cord-310192-8x37nx4s	158	29	(	(	-LRB-
cord-310192-8x37nx4s	158	30	Figure	Figure	NNP
cord-310192-8x37nx4s	158	31	3d	3d	NNP
cord-310192-8x37nx4s	158	32	)	)	-RRB-
cord-310192-8x37nx4s	158	33	.	.	.
cord-310192-8x37nx4s	159	1	This	this	DT
cord-310192-8x37nx4s	159	2	approach	approach	NN
cord-310192-8x37nx4s	159	3	was	be	VBD
cord-310192-8x37nx4s	159	4	pioneered	pioneer	VBN
cord-310192-8x37nx4s	159	5	in	in	IN
cord-310192-8x37nx4s	159	6	the	the	DT
cord-310192-8x37nx4s	159	7	Summers	Summers	NNPS
cord-310192-8x37nx4s	159	8	lab	lab	NN
cord-310192-8x37nx4s	159	9	and	and	CC
cord-310192-8x37nx4s	159	10	was	be	VBD
cord-310192-8x37nx4s	159	11	a	a	DT
cord-310192-8x37nx4s	159	12	requisite	requisite	JJ
cord-310192-8x37nx4s	159	13	for	for	IN
cord-310192-8x37nx4s	159	14	the	the	DT
cord-310192-8x37nx4s	159	15	unambiguous	unambiguous	JJ
cord-310192-8x37nx4s	159	16	identification	identification	NN
cord-310192-8x37nx4s	159	17	of	of	IN
cord-310192-8x37nx4s	159	18	an	an	DT
cord-310192-8x37nx4s	159	19	unexpected	unexpected	JJ
cord-310192-8x37nx4s	159	20	long	long	JJ
cord-310192-8x37nx4s	159	21	-	-	HYPH
cord-310192-8x37nx4s	159	22	range	range	NN
cord-310192-8x37nx4s	159	23	base	base	NN
cord-310192-8x37nx4s	159	24	pairing	pair	VBG
cord-310192-8x37nx4s	159	25	interaction	interaction	NN
cord-310192-8x37nx4s	159	26	within	within	IN
cord-310192-8x37nx4s	159	27	the	the	DT
cord-310192-8x37nx4s	159	28	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	159	29	F	F	NNP
cord-310192-8x37nx4s	159	30	I	i	NN
cord-310192-8x37nx4s	159	31	G	g	NN
cord-310192-8x37nx4s	159	32	U	u	NN
cord-310192-8x37nx4s	159	33	R	r	NN
cord-310192-8x37nx4s	159	34	E	e	NN
cord-310192-8x37nx4s	159	35	3	3	CD
cord-310192-8x37nx4s	159	36	Methods	method	NNS
cord-310192-8x37nx4s	159	37	for	for	IN
cord-310192-8x37nx4s	159	38	fragmentation	fragmentation	NN
cord-310192-8x37nx4s	159	39	or	or	CC
cord-310192-8x37nx4s	159	40	segmental	segmental	JJ
cord-310192-8x37nx4s	159	41	labeling	labeling	NN
cord-310192-8x37nx4s	159	42	of	of	IN
cord-310192-8x37nx4s	159	43	large	large	JJ
cord-310192-8x37nx4s	159	44	RNAs	rna	NNS
cord-310192-8x37nx4s	159	45	.	.	.
cord-310192-8x37nx4s	160	1	(	(	-LRB-
cord-310192-8x37nx4s	160	2	a	a	LS
cord-310192-8x37nx4s	160	3	)	)	-RRB-
cord-310192-8x37nx4s	160	4	Secondary	secondary	JJ
cord-310192-8x37nx4s	160	5	structure	structure	NN
cord-310192-8x37nx4s	160	6	of	of	IN
cord-310192-8x37nx4s	160	7	a	a	DT
cord-310192-8x37nx4s	160	8	large	large	JJ
cord-310192-8x37nx4s	160	9	RNA	RNA	NNP
cord-310192-8x37nx4s	160	10	with	with	IN
cord-310192-8x37nx4s	160	11	a	a	DT
cord-310192-8x37nx4s	160	12	complex	complex	JJ
cord-310192-8x37nx4s	160	13	multihelix	multihelix	NNP
cord-310192-8x37nx4s	160	14	junction	junction	NN
cord-310192-8x37nx4s	160	15	.	.	.
cord-310192-8x37nx4s	161	1	(	(	-LRB-
cord-310192-8x37nx4s	161	2	b	b	LS
cord-310192-8x37nx4s	161	3	)	)	-RRB-
cord-310192-8x37nx4s	161	4	"	"	``
cord-310192-8x37nx4s	161	5	Divide	divide	VB
cord-310192-8x37nx4s	161	6	and	and	CC
cord-310192-8x37nx4s	161	7	conquer	conquer	VB
cord-310192-8x37nx4s	161	8	"	"	''
cord-310192-8x37nx4s	161	9	approach	approach	NN
cord-310192-8x37nx4s	161	10	.	.	.
cord-310192-8x37nx4s	162	1	Small	small	JJ
cord-310192-8x37nx4s	162	2	oligo	oligo	NN
cord-310192-8x37nx4s	162	3	RNAs	rna	NNS
cord-310192-8x37nx4s	162	4	are	be	VBP
cord-310192-8x37nx4s	162	5	designed	design	VBN
cord-310192-8x37nx4s	162	6	to	to	TO
cord-310192-8x37nx4s	162	7	mimic	mimic	VB
cord-310192-8x37nx4s	162	8	the	the	DT
cord-310192-8x37nx4s	162	9	structure	structure	NN
cord-310192-8x37nx4s	162	10	of	of	IN
cord-310192-8x37nx4s	162	11	particular	particular	JJ
cord-310192-8x37nx4s	162	12	regions	region	NNS
cord-310192-8x37nx4s	162	13	within	within	IN
cord-310192-8x37nx4s	162	14	the	the	DT
cord-310192-8x37nx4s	162	15	large	large	JJ
cord-310192-8x37nx4s	162	16	RNA	RNA	NNP
cord-310192-8x37nx4s	162	17	.	.	.
cord-310192-8x37nx4s	163	1	These	these	DT
cord-310192-8x37nx4s	163	2	oligo	oligo	NN
cord-310192-8x37nx4s	163	3	RNAs	rna	NNS
cord-310192-8x37nx4s	163	4	are	be	VBP
cord-310192-8x37nx4s	163	5	well	well	RB
cord-310192-8x37nx4s	163	6	-	-	HYPH
cord-310192-8x37nx4s	163	7	suited	suit	VBN
cord-310192-8x37nx4s	163	8	for	for	IN
cord-310192-8x37nx4s	163	9	rapid	rapid	JJ
cord-310192-8x37nx4s	163	10	chemical	chemical	JJ
cord-310192-8x37nx4s	163	11	shift	shift	NN
cord-310192-8x37nx4s	163	12	assignment	assignment	NN
cord-310192-8x37nx4s	163	13	by	by	IN
cord-310192-8x37nx4s	163	14	traditional	traditional	JJ
cord-310192-8x37nx4s	163	15	methods	method	NNS
cord-310192-8x37nx4s	163	16	.	.	.
cord-310192-8x37nx4s	164	1	(	(	-LRB-
cord-310192-8x37nx4s	164	2	c	c	LS
cord-310192-8x37nx4s	164	3	)	)	-RRB-
cord-310192-8x37nx4s	164	4	Enzymatic	enzymatic	JJ
cord-310192-8x37nx4s	164	5	ligation	ligation	NN
cord-310192-8x37nx4s	164	6	allows	allow	VBZ
cord-310192-8x37nx4s	164	7	for	for	IN
cord-310192-8x37nx4s	164	8	segmental	segmental	JJ
cord-310192-8x37nx4s	164	9	labeling	labeling	NN
cord-310192-8x37nx4s	164	10	of	of	IN
cord-310192-8x37nx4s	164	11	a	a	DT
cord-310192-8x37nx4s	164	12	large	large	JJ
cord-310192-8x37nx4s	164	13	RNAs	rna	NNS
cord-310192-8x37nx4s	164	14	.	.	.
cord-310192-8x37nx4s	165	1	Two	two	CD
cord-310192-8x37nx4s	165	2	RNAs	rna	NNS
cord-310192-8x37nx4s	165	3	are	be	VBP
cord-310192-8x37nx4s	165	4	independently	independently	RB
cord-310192-8x37nx4s	165	5	synthesized	synthesize	VBN
cord-310192-8x37nx4s	165	6	and	and	CC
cord-310192-8x37nx4s	165	7	can	can	MD
cord-310192-8x37nx4s	165	8	therefore	therefore	RB
cord-310192-8x37nx4s	165	9	be	be	VB
cord-310192-8x37nx4s	165	10	independently	independently	RB
cord-310192-8x37nx4s	165	11	labeled	label	VBN
cord-310192-8x37nx4s	165	12	.	.	.
cord-310192-8x37nx4s	166	1	The	the	DT
cord-310192-8x37nx4s	166	2	two	two	CD
cord-310192-8x37nx4s	166	3	RNAs	rna	NNS
cord-310192-8x37nx4s	166	4	can	can	MD
cord-310192-8x37nx4s	166	5	then	then	RB
cord-310192-8x37nx4s	166	6	be	be	VB
cord-310192-8x37nx4s	166	7	ligated	ligate	VBN
cord-310192-8x37nx4s	166	8	together	together	RB
cord-310192-8x37nx4s	166	9	to	to	TO
cord-310192-8x37nx4s	166	10	make	make	VB
cord-310192-8x37nx4s	166	11	a	a	DT
cord-310192-8x37nx4s	166	12	full	full	JJ
cord-310192-8x37nx4s	166	13	-	-	HYPH
cord-310192-8x37nx4s	166	14	length	length	NN
cord-310192-8x37nx4s	166	15	construct	construct	NN
cord-310192-8x37nx4s	166	16	with	with	IN
cord-310192-8x37nx4s	166	17	only	only	RB
cord-310192-8x37nx4s	166	18	one	one	CD
cord-310192-8x37nx4s	166	19	region	region	NN
cord-310192-8x37nx4s	166	20	of	of	IN
cord-310192-8x37nx4s	166	21	the	the	DT
cord-310192-8x37nx4s	166	22	RNA	RNA	NNP
cord-310192-8x37nx4s	166	23	containing	contain	VBG
cord-310192-8x37nx4s	166	24	nuclear	nuclear	JJ
cord-310192-8x37nx4s	166	25	magnetic	magnetic	JJ
cord-310192-8x37nx4s	166	26	resonance	resonance	NN
cord-310192-8x37nx4s	166	27	-	-	HYPH
cord-310192-8x37nx4s	166	28	active	active	JJ
cord-310192-8x37nx4s	166	29	isotope	isotope	NN
cord-310192-8x37nx4s	166	30	labeling	labeling	NN
cord-310192-8x37nx4s	166	31	.	.	.
cord-310192-8x37nx4s	167	1	(	(	-LRB-
cord-310192-8x37nx4s	167	2	d	d	LS
cord-310192-8x37nx4s	167	3	)	)	-RRB-
cord-310192-8x37nx4s	167	4	Fragmentation	fragmentation	NN
cord-310192-8x37nx4s	167	5	-	-	HYPH
cord-310192-8x37nx4s	167	6	based	base	VBN
cord-310192-8x37nx4s	167	7	segmental	segmental	JJ
cord-310192-8x37nx4s	167	8	labeling	labeling	NN
cord-310192-8x37nx4s	167	9	.	.	.
cord-310192-8x37nx4s	168	1	The	the	DT
cord-310192-8x37nx4s	168	2	RNA	RNA	NNP
cord-310192-8x37nx4s	168	3	of	of	IN
cord-310192-8x37nx4s	168	4	interest	interest	NN
cord-310192-8x37nx4s	168	5	is	be	VBZ
cord-310192-8x37nx4s	168	6	fragmented	fragment	VBN
cord-310192-8x37nx4s	168	7	at	at	IN
cord-310192-8x37nx4s	168	8	a	a	DT
cord-310192-8x37nx4s	168	9	hairpin	hairpin	JJ
cord-310192-8x37nx4s	168	10	loop	loop	NN
cord-310192-8x37nx4s	168	11	.	.	.
cord-310192-8x37nx4s	169	1	The	the	DT
cord-310192-8x37nx4s	169	2	loop	loop	NN
cord-310192-8x37nx4s	169	3	sequence	sequence	NN
cord-310192-8x37nx4s	169	4	is	be	VBZ
cord-310192-8x37nx4s	169	5	replaced	replace	VBN
cord-310192-8x37nx4s	169	6	(	(	-LRB-
cord-310192-8x37nx4s	169	7	in	in	IN
cord-310192-8x37nx4s	169	8	some	some	DT
cord-310192-8x37nx4s	169	9	cases	case	NNS
cord-310192-8x37nx4s	169	10	)	)	-RRB-
cord-310192-8x37nx4s	169	11	with	with	IN
cord-310192-8x37nx4s	169	12	a	a	DT
cord-310192-8x37nx4s	169	13	run	run	NN
cord-310192-8x37nx4s	169	14	of	of	IN
cord-310192-8x37nx4s	169	15	intermolecular	intermolecular	JJ
cord-310192-8x37nx4s	169	16	C	c	NN
cord-310192-8x37nx4s	169	17	-	-	HYPH
cord-310192-8x37nx4s	169	18	G	g	NN
cord-310192-8x37nx4s	169	19	base	base	NN
cord-310192-8x37nx4s	169	20	pairs	pair	NNS
cord-310192-8x37nx4s	169	21	which	which	WDT
cord-310192-8x37nx4s	169	22	serve	serve	VBP
cord-310192-8x37nx4s	169	23	as	as	IN
cord-310192-8x37nx4s	169	24	an	an	DT
cord-310192-8x37nx4s	169	25	annealing	annealing	NN
cord-310192-8x37nx4s	169	26	handle	handle	NN
cord-310192-8x37nx4s	169	27	.	.	.
cord-310192-8x37nx4s	170	1	This	this	DT
cord-310192-8x37nx4s	170	2	approach	approach	NN
cord-310192-8x37nx4s	170	3	in	in	IN
cord-310192-8x37nx4s	170	4	theory	theory	NN
cord-310192-8x37nx4s	170	5	can	can	MD
cord-310192-8x37nx4s	170	6	be	be	VB
cord-310192-8x37nx4s	170	7	applied	apply	VBN
cord-310192-8x37nx4s	170	8	at	at	IN
cord-310192-8x37nx4s	170	9	any	any	DT
cord-310192-8x37nx4s	170	10	hairpin	hairpin	JJ
cord-310192-8x37nx4s	170	11	loop	loop	NN
cord-310192-8x37nx4s	170	12	structure	structure	NN
cord-310192-8x37nx4s	170	13	within	within	IN
cord-310192-8x37nx4s	170	14	a	a	DT
cord-310192-8x37nx4s	170	15	large	large	JJ
cord-310192-8x37nx4s	170	16	RNA	RNA	NNP
cord-310192-8x37nx4s	170	17	molecules	molecule	NNS
cord-310192-8x37nx4s	170	18	packaging	packaging	NN
cord-310192-8x37nx4s	170	19	signal	signal	NN
cord-310192-8x37nx4s	170	20	(	(	-LRB-
cord-310192-8x37nx4s	170	21	Keane	Keane	NNP
cord-310192-8x37nx4s	170	22	et	et	NNP
cord-310192-8x37nx4s	170	23	al	al	NNP
cord-310192-8x37nx4s	170	24	.	.	NNP
cord-310192-8x37nx4s	170	25	,	,	,
cord-310192-8x37nx4s	170	26	2015	2015	CD
cord-310192-8x37nx4s	170	27	)	)	-RRB-
cord-310192-8x37nx4s	170	28	.	.	.
cord-310192-8x37nx4s	171	1	In	in	IN
cord-310192-8x37nx4s	171	2	this	this	DT
cord-310192-8x37nx4s	171	3	work	work	NN
cord-310192-8x37nx4s	171	4	,	,	,
cord-310192-8x37nx4s	171	5	the	the	DT
cord-310192-8x37nx4s	171	6	authors	author	NNS
cord-310192-8x37nx4s	171	7	replaced	replace	VBD
cord-310192-8x37nx4s	171	8	a	a	DT
cord-310192-8x37nx4s	171	9	hairpin	hairpin	NN
cord-310192-8x37nx4s	171	10	loop	loop	NN
cord-310192-8x37nx4s	171	11	with	with	IN
cord-310192-8x37nx4s	171	12	a	a	DT
cord-310192-8x37nx4s	171	13	run	run	NN
cord-310192-8x37nx4s	171	14	of	of	IN
cord-310192-8x37nx4s	171	15	intermolecular	intermolecular	JJ
cord-310192-8x37nx4s	171	16	C	c	NN
cord-310192-8x37nx4s	171	17	-	-	HYPH
cord-310192-8x37nx4s	171	18	G	g	NN
cord-310192-8x37nx4s	171	19	base	base	NN
cord-310192-8x37nx4s	171	20	pairs	pair	NNS
cord-310192-8x37nx4s	171	21	,	,	,
cord-310192-8x37nx4s	171	22	fragmenting	fragment	VBG
cord-310192-8x37nx4s	171	23	the	the	DT
cord-310192-8x37nx4s	171	24	RNA	RNA	NNP
cord-310192-8x37nx4s	171	25	into	into	IN
cord-310192-8x37nx4s	171	26	two	two	CD
cord-310192-8x37nx4s	171	27	discrete	discrete	JJ
cord-310192-8x37nx4s	171	28	pieces	piece	NNS
cord-310192-8x37nx4s	171	29	that	that	WDT
cord-310192-8x37nx4s	171	30	could	could	MD
cord-310192-8x37nx4s	171	31	be	be	VB
cord-310192-8x37nx4s	171	32	transcribed	transcribe	VBN
cord-310192-8x37nx4s	171	33	(	(	-LRB-
cord-310192-8x37nx4s	171	34	and	and	CC
cord-310192-8x37nx4s	171	35	therefore	therefore	RB
cord-310192-8x37nx4s	171	36	isotopically	isotopically	RB
cord-310192-8x37nx4s	171	37	labeled	label	VBN
cord-310192-8x37nx4s	171	38	)	)	-RRB-
cord-310192-8x37nx4s	171	39	independently	independently	RB
cord-310192-8x37nx4s	171	40	and	and	CC
cord-310192-8x37nx4s	171	41	annealed	anneal	VBN
cord-310192-8x37nx4s	171	42	together	together	RB
cord-310192-8x37nx4s	171	43	post	post	NN
cord-310192-8x37nx4s	171	44	purification	purification	NN
cord-310192-8x37nx4s	171	45	(	(	-LRB-
cord-310192-8x37nx4s	171	46	Keane	Keane	NNP
cord-310192-8x37nx4s	171	47	et	et	NNP
cord-310192-8x37nx4s	171	48	al	al	NNP
cord-310192-8x37nx4s	171	49	.	.	NNP
cord-310192-8x37nx4s	171	50	,	,	,
cord-310192-8x37nx4s	171	51	2015	2015	CD
cord-310192-8x37nx4s	171	52	)	)	-RRB-
cord-310192-8x37nx4s	171	53	.	.	.
cord-310192-8x37nx4s	172	1	A	a	DT
cord-310192-8x37nx4s	172	2	similar	similar	JJ
cord-310192-8x37nx4s	172	3	approach	approach	NN
cord-310192-8x37nx4s	172	4	was	be	VBD
cord-310192-8x37nx4s	172	5	used	use	VBN
cord-310192-8x37nx4s	172	6	to	to	TO
cord-310192-8x37nx4s	172	7	study	study	VB
cord-310192-8x37nx4s	172	8	a	a	DT
cord-310192-8x37nx4s	172	9	122	122	CD
cord-310192-8x37nx4s	172	10	nucleotide	nucleotide	JJ
cord-310192-8x37nx4s	172	11	transcriptional	transcriptional	NN
cord-310192-8x37nx4s	172	12	intermediate	intermediate	JJ
cord-310192-8x37nx4s	172	13	of	of	IN
cord-310192-8x37nx4s	172	14	the	the	DT
cord-310192-8x37nx4s	172	15	type	type	NN
cord-310192-8x37nx4s	173	1	I	-PRON-	PRP
cord-310192-8x37nx4s	173	2	-	-	HYPH
cord-310192-8x37nx4s	173	3	A	a	NN
cord-310192-8x37nx4s	173	4	2	2	CD
cord-310192-8x37nx4s	173	5	0	0	CD
cord-310192-8x37nx4s	173	6	-deoxyguanosine	-deoxyguanosine	CD
cord-310192-8x37nx4s	173	7	-	-	HYPH
cord-310192-8x37nx4s	173	8	sensing	sense	VBG
cord-310192-8x37nx4s	173	9	transcriptional	transcriptional	JJ
cord-310192-8x37nx4s	173	10	riboswitch	riboswitch	NN
cord-310192-8x37nx4s	173	11	(	(	-LRB-
cord-310192-8x37nx4s	173	12	Helmling	Helmling	NNP
cord-310192-8x37nx4s	173	13	et	et	FW
cord-310192-8x37nx4s	173	14	al	al	NNP
cord-310192-8x37nx4s	173	15	.	.	NNP
cord-310192-8x37nx4s	173	16	,	,	,
cord-310192-8x37nx4s	173	17	2017	2017	CD
cord-310192-8x37nx4s	173	18	)	)	-RRB-
cord-310192-8x37nx4s	173	19	.	.	.
cord-310192-8x37nx4s	174	1	Here	here	RB
cord-310192-8x37nx4s	174	2	,	,	,
cord-310192-8x37nx4s	174	3	a	a	DT
cord-310192-8x37nx4s	174	4	similar	similar	JJ
cord-310192-8x37nx4s	174	5	approach	approach	NN
cord-310192-8x37nx4s	174	6	was	be	VBD
cord-310192-8x37nx4s	174	7	used	use	VBN
cord-310192-8x37nx4s	174	8	,	,	,
cord-310192-8x37nx4s	174	9	a	a	DT
cord-310192-8x37nx4s	174	10	break	break	NN
cord-310192-8x37nx4s	174	11	in	in	IN
cord-310192-8x37nx4s	174	12	the	the	DT
cord-310192-8x37nx4s	174	13	sequence	sequence	NN
cord-310192-8x37nx4s	174	14	was	be	VBD
cord-310192-8x37nx4s	174	15	introduced	introduce	VBN
cord-310192-8x37nx4s	174	16	by	by	IN
cord-310192-8x37nx4s	174	17	removing	remove	VBG
cord-310192-8x37nx4s	174	18	a	a	DT
cord-310192-8x37nx4s	174	19	loop	loop	NN
cord-310192-8x37nx4s	174	20	;	;	:
cord-310192-8x37nx4s	174	21	however	however	RB
cord-310192-8x37nx4s	174	22	,	,	,
cord-310192-8x37nx4s	174	23	a	a	DT
cord-310192-8x37nx4s	174	24	G	g	NN
cord-310192-8x37nx4s	174	25	-	-	HYPH
cord-310192-8x37nx4s	174	26	C	c	NN
cord-310192-8x37nx4s	174	27	handle	handle	NN
cord-310192-8x37nx4s	174	28	was	be	VBD
cord-310192-8x37nx4s	174	29	not	not	RB
cord-310192-8x37nx4s	174	30	included	include	VBN
cord-310192-8x37nx4s	174	31	and	and	CC
cord-310192-8x37nx4s	174	32	may	may	MD
cord-310192-8x37nx4s	174	33	not	not	RB
cord-310192-8x37nx4s	174	34	be	be	VB
cord-310192-8x37nx4s	174	35	necessary	necessary	JJ
cord-310192-8x37nx4s	174	36	for	for	IN
cord-310192-8x37nx4s	174	37	all	all	DT
cord-310192-8x37nx4s	174	38	sequences	sequence	NNS
cord-310192-8x37nx4s	174	39	(	(	-LRB-
cord-310192-8x37nx4s	174	40	Helmling	Helmling	NNP
cord-310192-8x37nx4s	174	41	et	et	FW
cord-310192-8x37nx4s	174	42	al	al	NNP
cord-310192-8x37nx4s	174	43	.	.	NNP
cord-310192-8x37nx4s	174	44	,	,	,
cord-310192-8x37nx4s	174	45	2017	2017	CD
cord-310192-8x37nx4s	174	46	)	)	-RRB-
cord-310192-8x37nx4s	174	47	.	.	.
cord-310192-8x37nx4s	175	1	This	this	DT
cord-310192-8x37nx4s	175	2	approach	approach	NN
cord-310192-8x37nx4s	175	3	is	be	VBZ
cord-310192-8x37nx4s	175	4	versatile	versatile	JJ
cord-310192-8x37nx4s	175	5	as	as	IN
cord-310192-8x37nx4s	175	6	a	a	DT
cord-310192-8x37nx4s	175	7	fragmentation	fragmentation	NN
cord-310192-8x37nx4s	175	8	site	site	NN
cord-310192-8x37nx4s	175	9	can	can	MD
cord-310192-8x37nx4s	175	10	in	in	IN
cord-310192-8x37nx4s	175	11	principle	principle	NN
cord-310192-8x37nx4s	175	12	be	be	VB
cord-310192-8x37nx4s	175	13	incorporated	incorporate	VBN
cord-310192-8x37nx4s	175	14	at	at	IN
cord-310192-8x37nx4s	175	15	the	the	DT
cord-310192-8x37nx4s	175	16	loop	loop	NN
cord-310192-8x37nx4s	175	17	of	of	IN
cord-310192-8x37nx4s	175	18	any	any	DT
cord-310192-8x37nx4s	175	19	hairpin	hairpin	NN
cord-310192-8x37nx4s	175	20	element	element	NN
cord-310192-8x37nx4s	175	21	,	,	,
cord-310192-8x37nx4s	175	22	which	which	WDT
cord-310192-8x37nx4s	175	23	are	be	VBP
cord-310192-8x37nx4s	175	24	ubiquitous	ubiquitous	JJ
cord-310192-8x37nx4s	175	25	elements	element	NNS
cord-310192-8x37nx4s	175	26	in	in	IN
cord-310192-8x37nx4s	175	27	RNA	RNA	NNP
cord-310192-8x37nx4s	175	28	structures	structure	NNS
cord-310192-8x37nx4s	175	29	.	.	.
cord-310192-8x37nx4s	176	1	A	a	DT
cord-310192-8x37nx4s	176	2	caveat	caveat	NN
cord-310192-8x37nx4s	176	3	to	to	IN
cord-310192-8x37nx4s	176	4	this	this	DT
cord-310192-8x37nx4s	176	5	approach	approach	NN
cord-310192-8x37nx4s	176	6	is	be	VBZ
cord-310192-8x37nx4s	176	7	that	that	IN
cord-310192-8x37nx4s	176	8	individual	individual	JJ
cord-310192-8x37nx4s	176	9	fragments	fragment	NNS
cord-310192-8x37nx4s	176	10	might	may	MD
cord-310192-8x37nx4s	176	11	form	form	VB
cord-310192-8x37nx4s	176	12	a	a	DT
cord-310192-8x37nx4s	176	13	stable	stable	JJ
cord-310192-8x37nx4s	176	14	structure	structure	NN
cord-310192-8x37nx4s	176	15	that	that	WDT
cord-310192-8x37nx4s	176	16	inhibits	inhibit	VBZ
cord-310192-8x37nx4s	176	17	intermolecular	intermolecular	JJ
cord-310192-8x37nx4s	176	18	base	base	NN
cord-310192-8x37nx4s	176	19	pairing	pairing	NN
cord-310192-8x37nx4s	176	20	.	.	.
cord-310192-8x37nx4s	177	1	This	this	DT
cord-310192-8x37nx4s	177	2	approach	approach	NN
cord-310192-8x37nx4s	177	3	might	may	MD
cord-310192-8x37nx4s	177	4	not	not	RB
cord-310192-8x37nx4s	177	5	work	work	VB
cord-310192-8x37nx4s	177	6	for	for	IN
cord-310192-8x37nx4s	177	7	all	all	DT
cord-310192-8x37nx4s	177	8	RNAs	rna	NNS
cord-310192-8x37nx4s	177	9	or	or	CC
cord-310192-8x37nx4s	177	10	at	at	IN
cord-310192-8x37nx4s	177	11	all	all	DT
cord-310192-8x37nx4s	177	12	hairpin	hairpin	NN
cord-310192-8x37nx4s	177	13	loops	loop	NNS
cord-310192-8x37nx4s	177	14	and	and	CC
cord-310192-8x37nx4s	177	15	therefore	therefore	RB
cord-310192-8x37nx4s	177	16	must	must	MD
cord-310192-8x37nx4s	177	17	be	be	VB
cord-310192-8x37nx4s	177	18	rigorously	rigorously	RB
cord-310192-8x37nx4s	177	19	tested	test	VBN
cord-310192-8x37nx4s	177	20	to	to	TO
cord-310192-8x37nx4s	177	21	ensure	ensure	VB
cord-310192-8x37nx4s	177	22	proper	proper	JJ
cord-310192-8x37nx4s	177	23	formation	formation	NN
cord-310192-8x37nx4s	177	24	of	of	IN
cord-310192-8x37nx4s	177	25	the	the	DT
cord-310192-8x37nx4s	177	26	native	native	JJ
cord-310192-8x37nx4s	177	27	structure	structure	NN
cord-310192-8x37nx4s	177	28	.	.	.
cord-310192-8x37nx4s	178	1	One	one	CD
cord-310192-8x37nx4s	178	2	of	of	IN
cord-310192-8x37nx4s	178	3	the	the	DT
cord-310192-8x37nx4s	178	4	most	most	RBS
cord-310192-8x37nx4s	178	5	telling	telling	JJ
cord-310192-8x37nx4s	178	6	characteristics	characteristic	NNS
cord-310192-8x37nx4s	178	7	of	of	IN
cord-310192-8x37nx4s	178	8	RNA	RNA	NNP
cord-310192-8x37nx4s	178	9	structure	structure	NN
cord-310192-8x37nx4s	178	10	is	be	VBZ
cord-310192-8x37nx4s	178	11	the	the	DT
cord-310192-8x37nx4s	178	12	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	178	13	bonding	bonding	NN
cord-310192-8x37nx4s	178	14	pattern	pattern	NN
cord-310192-8x37nx4s	178	15	,	,	,
cord-310192-8x37nx4s	178	16	the	the	DT
cord-310192-8x37nx4s	178	17	base	base	NN
cord-310192-8x37nx4s	178	18	pairing	pair	VBG
cord-310192-8x37nx4s	178	19	within	within	IN
cord-310192-8x37nx4s	178	20	the	the	DT
cord-310192-8x37nx4s	178	21	molecule	molecule	NN
cord-310192-8x37nx4s	178	22	.	.	.
cord-310192-8x37nx4s	179	1	An	an	DT
cord-310192-8x37nx4s	179	2	NMR	NMR	NNP
cord-310192-8x37nx4s	179	3	spectrum	spectrum	NN
cord-310192-8x37nx4s	179	4	that	that	WDT
cord-310192-8x37nx4s	179	5	reports	report	VBZ
cord-310192-8x37nx4s	179	6	on	on	IN
cord-310192-8x37nx4s	179	7	the	the	DT
cord-310192-8x37nx4s	179	8	base	base	NN
cord-310192-8x37nx4s	179	9	pairing	pair	VBG
cord-310192-8x37nx4s	179	10	within	within	IN
cord-310192-8x37nx4s	179	11	an	an	DT
cord-310192-8x37nx4s	179	12	RNA	RNA	NNP
cord-310192-8x37nx4s	179	13	can	can	MD
cord-310192-8x37nx4s	179	14	serve	serve	VB
cord-310192-8x37nx4s	179	15	as	as	IN
cord-310192-8x37nx4s	179	16	a	a	DT
cord-310192-8x37nx4s	179	17	"	"	``
cord-310192-8x37nx4s	179	18	fingerprint	fingerprint	NN
cord-310192-8x37nx4s	179	19	"	"	''
cord-310192-8x37nx4s	179	20	of	of	IN
cord-310192-8x37nx4s	179	21	the	the	DT
cord-310192-8x37nx4s	179	22	molecule	molecule	NN
cord-310192-8x37nx4s	179	23	.	.	.
cord-310192-8x37nx4s	180	1	Traditionally	traditionally	RB
cord-310192-8x37nx4s	180	2	,	,	,
cord-310192-8x37nx4s	180	3	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	180	4	bonding	bonding	NN
cord-310192-8x37nx4s	180	5	within	within	IN
cord-310192-8x37nx4s	180	6	small	small	JJ
cord-310192-8x37nx4s	180	7	RNAs	rna	NNS
cord-310192-8x37nx4s	180	8	has	have	VBZ
cord-310192-8x37nx4s	180	9	been	be	VBN
cord-310192-8x37nx4s	180	10	inferred	infer	VBN
cord-310192-8x37nx4s	180	11	through	through	IN
cord-310192-8x37nx4s	180	12	NOE	NOE	NNP
cord-310192-8x37nx4s	180	13	(	(	-LRB-
cord-310192-8x37nx4s	180	14	through	through	IN
cord-310192-8x37nx4s	180	15	space	space	NN
cord-310192-8x37nx4s	180	16	)	)	-RRB-
cord-310192-8x37nx4s	180	17	correlations	correlation	NNS
cord-310192-8x37nx4s	180	18	of	of	IN
cord-310192-8x37nx4s	180	19	imino	imino	NNP
cord-310192-8x37nx4s	180	20	protons	proton	NNS
cord-310192-8x37nx4s	180	21	(	(	-LRB-
cord-310192-8x37nx4s	180	22	Varani	Varani	NNP
cord-310192-8x37nx4s	180	23	,	,	,
cord-310192-8x37nx4s	180	24	Aboulela	Aboulela	NNP
cord-310192-8x37nx4s	180	25	,	,	,
cord-310192-8x37nx4s	180	26	&	&	CC
cord-310192-8x37nx4s	180	27	Allain	Allain	NNP
cord-310192-8x37nx4s	180	28	,	,	,
cord-310192-8x37nx4s	180	29	1996	1996	CD
cord-310192-8x37nx4s	180	30	;	;	:
cord-310192-8x37nx4s	180	31	Wüthrich	Wüthrich	NNP
cord-310192-8x37nx4s	180	32	,	,	,
cord-310192-8x37nx4s	180	33	1986	1986	CD
cord-310192-8x37nx4s	180	34	)	)	-RRB-
cord-310192-8x37nx4s	180	35	.	.	.
cord-310192-8x37nx4s	181	1	Hydrogen	hydrogen	NN
cord-310192-8x37nx4s	181	2	bonding	bonding	NN
cord-310192-8x37nx4s	181	3	can	can	MD
cord-310192-8x37nx4s	181	4	also	also	RB
cord-310192-8x37nx4s	181	5	be	be	VB
cord-310192-8x37nx4s	181	6	identified	identify	VBN
cord-310192-8x37nx4s	181	7	directly	directly	RB
cord-310192-8x37nx4s	181	8	using	use	VBG
cord-310192-8x37nx4s	181	9	a	a	DT
cord-310192-8x37nx4s	181	10	scalar	scalar	JJ
cord-310192-8x37nx4s	181	11	coupling	coupling	NN
cord-310192-8x37nx4s	181	12	HNN	HNN	NNP
cord-310192-8x37nx4s	181	13	-	-	HYPH
cord-310192-8x37nx4s	181	14	COSY	COSY	NNP
cord-310192-8x37nx4s	181	15	(	(	-LRB-
cord-310192-8x37nx4s	181	16	through	through	IN
cord-310192-8x37nx4s	181	17	bond	bond	NN
cord-310192-8x37nx4s	181	18	)	)	-RRB-
cord-310192-8x37nx4s	181	19	experiment	experiment	NN
cord-310192-8x37nx4s	181	20	(	(	-LRB-
cord-310192-8x37nx4s	181	21	Dingley	Dingley	NNP
cord-310192-8x37nx4s	181	22	&	&	CC
cord-310192-8x37nx4s	181	23	Grzesiek	Grzesiek	NNP
cord-310192-8x37nx4s	181	24	,	,	,
cord-310192-8x37nx4s	181	25	1998	1998	CD
cord-310192-8x37nx4s	181	26	;	;	:
cord-310192-8x37nx4s	182	1	Pervushin	Pervushin	NNP
cord-310192-8x37nx4s	182	2	et	et	NNP
cord-310192-8x37nx4s	182	3	al	al	NNP
cord-310192-8x37nx4s	182	4	.	.	NNP
cord-310192-8x37nx4s	182	5	,	,	,
cord-310192-8x37nx4s	182	6	1998	1998	CD
cord-310192-8x37nx4s	182	7	)	)	-RRB-
cord-310192-8x37nx4s	182	8	.	.	.
cord-310192-8x37nx4s	183	1	Additional	additional	JJ
cord-310192-8x37nx4s	183	2	improvements	improvement	NNS
cord-310192-8x37nx4s	183	3	in	in	IN
cord-310192-8x37nx4s	183	4	sensitivity	sensitivity	NN
cord-310192-8x37nx4s	183	5	can	can	MD
cord-310192-8x37nx4s	183	6	be	be	VB
cord-310192-8x37nx4s	183	7	gained	gain	VBN
cord-310192-8x37nx4s	183	8	by	by	IN
cord-310192-8x37nx4s	183	9	implementation	implementation	NN
cord-310192-8x37nx4s	183	10	of	of	IN
cord-310192-8x37nx4s	183	11	longitudinal	longitudinal	JJ
cord-310192-8x37nx4s	183	12	-	-	HYPH
cord-310192-8x37nx4s	183	13	relaxation	relaxation	NN
cord-310192-8x37nx4s	183	14	-	-	HYPH
cord-310192-8x37nx4s	183	15	enhancement	enhancement	NN
cord-310192-8x37nx4s	183	16	techniques	technique	NNS
cord-310192-8x37nx4s	183	17	such	such	JJ
cord-310192-8x37nx4s	183	18	as	as	IN
cord-310192-8x37nx4s	183	19	BEST	best	JJ
cord-310192-8x37nx4s	183	20	-	-	HYPH
cord-310192-8x37nx4s	183	21	HNN	hnn	NN
cord-310192-8x37nx4s	183	22	-	-	HYPH
cord-310192-8x37nx4s	183	23	COSY	cosy	JJ
cord-310192-8x37nx4s	183	24	experiments	experiment	NNS
cord-310192-8x37nx4s	183	25	which	which	WDT
cord-310192-8x37nx4s	183	26	selectively	selectively	RB
cord-310192-8x37nx4s	183	27	excite	excite	VBP
cord-310192-8x37nx4s	183	28	only	only	RB
cord-310192-8x37nx4s	183	29	desired	desire	VBN
cord-310192-8x37nx4s	183	30	nuclei	nucleus	NNS
cord-310192-8x37nx4s	183	31	which	which	WDT
cord-310192-8x37nx4s	183	32	shortens	shorten	VBZ
cord-310192-8x37nx4s	183	33	experimental	experimental	JJ
cord-310192-8x37nx4s	183	34	acquisition	acquisition	NN
cord-310192-8x37nx4s	183	35	time	time	NN
cord-310192-8x37nx4s	183	36	and	and	CC
cord-310192-8x37nx4s	183	37	improves	improve	VBZ
cord-310192-8x37nx4s	183	38	signal	signal	NN
cord-310192-8x37nx4s	183	39	:	:	:
cord-310192-8x37nx4s	183	40	noise	noise	NN
cord-310192-8x37nx4s	183	41	(	(	-LRB-
cord-310192-8x37nx4s	183	42	Farjon	Farjon	NNP
cord-310192-8x37nx4s	183	43	et	et	FW
cord-310192-8x37nx4s	183	44	al	al	NNP
cord-310192-8x37nx4s	183	45	.	.	NNP
cord-310192-8x37nx4s	183	46	,	,	,
cord-310192-8x37nx4s	183	47	2009	2009	CD
cord-310192-8x37nx4s	183	48	)	)	-RRB-
cord-310192-8x37nx4s	183	49	.	.	.
cord-310192-8x37nx4s	184	1	However	however	RB
cord-310192-8x37nx4s	184	2	,	,	,
cord-310192-8x37nx4s	184	3	all	all	DT
cord-310192-8x37nx4s	184	4	of	of	IN
cord-310192-8x37nx4s	184	5	these	these	DT
cord-310192-8x37nx4s	184	6	experiments	experiment	NNS
cord-310192-8x37nx4s	184	7	rely	rely	VBP
cord-310192-8x37nx4s	184	8	on	on	IN
cord-310192-8x37nx4s	184	9	the	the	DT
cord-310192-8x37nx4s	184	10	detection	detection	NN
cord-310192-8x37nx4s	184	11	of	of	IN
cord-310192-8x37nx4s	184	12	the	the	DT
cord-310192-8x37nx4s	184	13	imino	imino	NNP
cord-310192-8x37nx4s	184	14	proton	proton	NN
cord-310192-8x37nx4s	184	15	,	,	,
cord-310192-8x37nx4s	184	16	a	a	DT
cord-310192-8x37nx4s	184	17	proton	proton	NN
cord-310192-8x37nx4s	184	18	that	that	WDT
cord-310192-8x37nx4s	184	19	is	be	VBZ
cord-310192-8x37nx4s	184	20	readily	readily	RB
cord-310192-8x37nx4s	184	21	exchangeable	exchangeable	JJ
cord-310192-8x37nx4s	184	22	with	with	IN
cord-310192-8x37nx4s	184	23	solvent	solvent	NN
cord-310192-8x37nx4s	184	24	and	and	CC
cord-310192-8x37nx4s	184	25	subject	subject	JJ
cord-310192-8x37nx4s	184	26	to	to	IN
cord-310192-8x37nx4s	184	27	conformational	conformational	JJ
cord-310192-8x37nx4s	184	28	dynamics	dynamic	NNS
cord-310192-8x37nx4s	184	29	at	at	IN
cord-310192-8x37nx4s	184	30	elevated	elevated	JJ
cord-310192-8x37nx4s	184	31	temperatures	temperature	NNS
cord-310192-8x37nx4s	184	32	(	(	-LRB-
cord-310192-8x37nx4s	184	33	Gao	Gao	NNP
cord-310192-8x37nx4s	184	34	&	&	CC
cord-310192-8x37nx4s	184	35	Patel	Patel	NNP
cord-310192-8x37nx4s	184	36	,	,	,
cord-310192-8x37nx4s	184	37	1987	1987	CD
cord-310192-8x37nx4s	184	38	;	;	:
cord-310192-8x37nx4s	184	39	J.	J.	NNP
cord-310192-8x37nx4s	184	40	H.	H.	NNP
cord-310192-8x37nx4s	184	41	Lee	Lee	NNP
cord-310192-8x37nx4s	184	42	,	,	,
cord-310192-8x37nx4s	184	43	Jucker	Jucker	NNP
cord-310192-8x37nx4s	184	44	,	,	,
cord-310192-8x37nx4s	184	45	&	&	CC
cord-310192-8x37nx4s	184	46	Pardi	Pardi	NNP
cord-310192-8x37nx4s	184	47	,	,	,
cord-310192-8x37nx4s	184	48	2008	2008	CD
cord-310192-8x37nx4s	184	49	;	;	:
cord-310192-8x37nx4s	184	50	Wagner	Wagner	NNP
cord-310192-8x37nx4s	184	51	,	,	,
cord-310192-8x37nx4s	184	52	Rinnenthal	Rinnenthal	NNP
cord-310192-8x37nx4s	184	53	,	,	,
cord-310192-8x37nx4s	184	54	Narberhaus	Narberhaus	NNP
cord-310192-8x37nx4s	184	55	,	,	,
cord-310192-8x37nx4s	184	56	&	&	CC
cord-310192-8x37nx4s	184	57	Schwalbe	Schwalbe	NNP
cord-310192-8x37nx4s	184	58	,	,	,
cord-310192-8x37nx4s	184	59	2015	2015	CD
cord-310192-8x37nx4s	184	60	)	)	-RRB-
cord-310192-8x37nx4s	184	61	.	.	.
cord-310192-8x37nx4s	185	1	The	the	DT
cord-310192-8x37nx4s	185	2	imino	imino	JJ
cord-310192-8x37nx4s	185	3	protons	proton	NNS
cord-310192-8x37nx4s	185	4	of	of	IN
cord-310192-8x37nx4s	185	5	transient	transient	JJ
cord-310192-8x37nx4s	185	6	base	base	NN
cord-310192-8x37nx4s	185	7	pairs	pair	NNS
cord-310192-8x37nx4s	185	8	can	can	MD
cord-310192-8x37nx4s	185	9	be	be	VB
cord-310192-8x37nx4s	185	10	broadened	broaden	VBN
cord-310192-8x37nx4s	185	11	beyond	beyond	IN
cord-310192-8x37nx4s	185	12	detection	detection	NN
cord-310192-8x37nx4s	185	13	due	due	IN
cord-310192-8x37nx4s	185	14	to	to	TO
cord-310192-8x37nx4s	185	15	exchange	exchange	VB
cord-310192-8x37nx4s	185	16	with	with	IN
cord-310192-8x37nx4s	185	17	solvent	solvent	NN
cord-310192-8x37nx4s	185	18	therefore	therefore	RB
cord-310192-8x37nx4s	185	19	these	these	DT
cord-310192-8x37nx4s	185	20	experiments	experiment	NNS
cord-310192-8x37nx4s	185	21	are	be	VBP
cord-310192-8x37nx4s	185	22	typically	typically	RB
cord-310192-8x37nx4s	185	23	conducted	conduct	VBN
cord-310192-8x37nx4s	185	24	at	at	IN
cord-310192-8x37nx4s	185	25	temperatures	temperature	NNS
cord-310192-8x37nx4s	185	26	below	below	IN
cord-310192-8x37nx4s	185	27	room	room	NN
cord-310192-8x37nx4s	185	28	temperature	temperature	NN
cord-310192-8x37nx4s	185	29	(	(	-LRB-
cord-310192-8x37nx4s	185	30	typically	typically	RB
cord-310192-8x37nx4s	185	31	around	around	IN
cord-310192-8x37nx4s	185	32	10	10	CD
cord-310192-8x37nx4s	185	33	C	C	NNP
cord-310192-8x37nx4s	185	34	)	)	-RRB-
cord-310192-8x37nx4s	185	35	.	.	.
cord-310192-8x37nx4s	186	1	Large	large	JJ
cord-310192-8x37nx4s	186	2	RNAs	rna	NNS
cord-310192-8x37nx4s	186	3	are	be	VBP
cord-310192-8x37nx4s	186	4	generally	generally	RB
cord-310192-8x37nx4s	186	5	not	not	RB
cord-310192-8x37nx4s	186	6	amenable	amenable	JJ
cord-310192-8x37nx4s	186	7	to	to	TO
cord-310192-8x37nx4s	186	8	study	study	VB
cord-310192-8x37nx4s	186	9	at	at	IN
cord-310192-8x37nx4s	186	10	low	low	JJ
cord-310192-8x37nx4s	186	11	temperature	temperature	NN
cord-310192-8x37nx4s	186	12	due	due	IN
cord-310192-8x37nx4s	186	13	to	to	IN
cord-310192-8x37nx4s	186	14	the	the	DT
cord-310192-8x37nx4s	186	15	slower	slow	JJR
cord-310192-8x37nx4s	186	16	molecular	molecular	JJ
cord-310192-8x37nx4s	186	17	tumbling	tumble	VBG
cord-310192-8x37nx4s	186	18	.	.	.
cord-310192-8x37nx4s	187	1	Nevertheless	nevertheless	RB
cord-310192-8x37nx4s	187	2	,	,	,
cord-310192-8x37nx4s	187	3	imino	imino	JJ
cord-310192-8x37nx4s	187	4	assignments	assignment	NNS
cord-310192-8x37nx4s	187	5	have	have	VBP
cord-310192-8x37nx4s	187	6	been	be	VBN
cord-310192-8x37nx4s	187	7	made	make	VBN
cord-310192-8x37nx4s	187	8	for	for	IN
cord-310192-8x37nx4s	187	9	several	several	JJ
cord-310192-8x37nx4s	187	10	large	large	JJ
cord-310192-8x37nx4s	187	11	RNAs	rna	NNS
cord-310192-8x37nx4s	187	12	including	include	VBG
cord-310192-8x37nx4s	187	13	the	the	DT
cord-310192-8x37nx4s	187	14	111	111	CD
cord-310192-8x37nx4s	187	15	nt	nt	NNP
cord-310192-8x37nx4s	187	16	U2	U2	NNP
cord-310192-8x37nx4s	187	17	/	/	SYM
cord-310192-8x37nx4s	187	18	U6	U6	NNP
cord-310192-8x37nx4s	187	19	snRNA	snrna	NN
cord-310192-8x37nx4s	187	20	complex	complex	NN
cord-310192-8x37nx4s	187	21	(	(	-LRB-
cord-310192-8x37nx4s	187	22	Burke	Burke	NNP
cord-310192-8x37nx4s	187	23	,	,	,
cord-310192-8x37nx4s	187	24	Sashital	Sashital	NNP
cord-310192-8x37nx4s	187	25	,	,	,
cord-310192-8x37nx4s	187	26	Zuo	Zuo	NNP
cord-310192-8x37nx4s	187	27	,	,	,
cord-310192-8x37nx4s	187	28	Wang	Wang	NNP
cord-310192-8x37nx4s	187	29	,	,	,
cord-310192-8x37nx4s	187	30	&	&	CC
cord-310192-8x37nx4s	187	31	Butcher	Butcher	NNP
cord-310192-8x37nx4s	187	32	,	,	,
cord-310192-8x37nx4s	187	33	2012	2012	CD
cord-310192-8x37nx4s	187	34	)	)	-RRB-
cord-310192-8x37nx4s	187	35	,	,	,
cord-310192-8x37nx4s	187	36	a	a	DT
cord-310192-8x37nx4s	187	37	67	67	CD
cord-310192-8x37nx4s	187	38	nt	nt	NNP
cord-310192-8x37nx4s	187	39	region	region	NN
cord-310192-8x37nx4s	187	40	of	of	IN
cord-310192-8x37nx4s	187	41	the	the	DT
cord-310192-8x37nx4s	187	42	encephalomyocarditis	encephalomyocarditis	NNP
cord-310192-8x37nx4s	187	43	virus	virus	NN
cord-310192-8x37nx4s	187	44	IRES	IRES	NNP
cord-310192-8x37nx4s	187	45	(	(	-LRB-
cord-310192-8x37nx4s	187	46	Imai	Imai	NNP
cord-310192-8x37nx4s	187	47	et	et	NNP
cord-310192-8x37nx4s	187	48	al	al	NNP
cord-310192-8x37nx4s	187	49	.	.	NNP
cord-310192-8x37nx4s	187	50	,	,	,
cord-310192-8x37nx4s	187	51	2016	2016	CD
cord-310192-8x37nx4s	187	52	)	)	-RRB-
cord-310192-8x37nx4s	187	53	,	,	,
cord-310192-8x37nx4s	187	54	and	and	CC
cord-310192-8x37nx4s	187	55	the	the	DT
cord-310192-8x37nx4s	187	56	112	112	CD
cord-310192-8x37nx4s	187	57	nt	nt	RB
cord-310192-8x37nx4s	187	58	adenine	adenine	JJ
cord-310192-8x37nx4s	187	59	riboswitch	riboswitch	NN
cord-310192-8x37nx4s	187	60	(	(	-LRB-
cord-310192-8x37nx4s	187	61	Reining	rein	VBG
cord-310192-8x37nx4s	187	62	et	et	FW
cord-310192-8x37nx4s	187	63	al	al	NNP
cord-310192-8x37nx4s	187	64	.	.	NNP
cord-310192-8x37nx4s	187	65	,	,	,
cord-310192-8x37nx4s	187	66	2013	2013	CD
cord-310192-8x37nx4s	187	67	)	)	-RRB-
cord-310192-8x37nx4s	187	68	.	.	.
cord-310192-8x37nx4s	188	1	The	the	DT
cord-310192-8x37nx4s	188	2	Sattler	Sattler	NNP
cord-310192-8x37nx4s	188	3	lab	lab	NN
cord-310192-8x37nx4s	188	4	made	make	VBD
cord-310192-8x37nx4s	188	5	important	important	JJ
cord-310192-8x37nx4s	188	6	improvements	improvement	NNS
cord-310192-8x37nx4s	188	7	to	to	IN
cord-310192-8x37nx4s	188	8	the	the	DT
cord-310192-8x37nx4s	188	9	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	188	10	bond	bond	NN
cord-310192-8x37nx4s	188	11	correlation	correlation	NN
cord-310192-8x37nx4s	188	12	experiments	experiment	NNS
cord-310192-8x37nx4s	188	13	,	,	,
cord-310192-8x37nx4s	188	14	utilizing	utilize	VBG
cord-310192-8x37nx4s	188	15	band	band	NN
cord-310192-8x37nx4s	188	16	-	-	HYPH
cord-310192-8x37nx4s	188	17	selective	selective	JJ
cord-310192-8x37nx4s	188	18	pulses	pulse	NNS
cord-310192-8x37nx4s	188	19	coupled	couple	VBN
cord-310192-8x37nx4s	188	20	with	with	IN
cord-310192-8x37nx4s	188	21	BEST	best	JJ
cord-310192-8x37nx4s	188	22	relaxation	relaxation	NN
cord-310192-8x37nx4s	188	23	enhancement	enhancement	NN
cord-310192-8x37nx4s	188	24	to	to	TO
cord-310192-8x37nx4s	188	25	enable	enable	VB
cord-310192-8x37nx4s	188	26	detection	detection	NN
cord-310192-8x37nx4s	188	27	of	of	IN
cord-310192-8x37nx4s	188	28	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	188	29	bonds	bond	NNS
cord-310192-8x37nx4s	188	30	in	in	IN
cord-310192-8x37nx4s	188	31	dynamic	dynamic	JJ
cord-310192-8x37nx4s	188	32	regions	region	NNS
cord-310192-8x37nx4s	188	33	of	of	IN
cord-310192-8x37nx4s	188	34	RNA	RNA	NNP
cord-310192-8x37nx4s	188	35	(	(	-LRB-
cord-310192-8x37nx4s	188	36	Dallmann	Dallmann	NNP
cord-310192-8x37nx4s	188	37	et	et	NNP
cord-310192-8x37nx4s	188	38	al	al	NNP
cord-310192-8x37nx4s	188	39	.	.	NNP
cord-310192-8x37nx4s	188	40	,	,	,
cord-310192-8x37nx4s	188	41	2013	2013	CD
cord-310192-8x37nx4s	188	42	)	)	-RRB-
cord-310192-8x37nx4s	188	43	.	.	.
cord-310192-8x37nx4s	189	1	These	these	DT
cord-310192-8x37nx4s	189	2	methodological	methodological	JJ
cord-310192-8x37nx4s	189	3	improvements	improvement	NNS
cord-310192-8x37nx4s	189	4	allow	allow	VBP
cord-310192-8x37nx4s	189	5	for	for	IN
cord-310192-8x37nx4s	189	6	work	work	NN
cord-310192-8x37nx4s	189	7	at	at	IN
cord-310192-8x37nx4s	189	8	high	high	JJ
cord-310192-8x37nx4s	189	9	temperature	temperature	NN
cord-310192-8x37nx4s	189	10	without	without	IN
cord-310192-8x37nx4s	189	11	exchange	exchange	NN
cord-310192-8x37nx4s	189	12	concerns	concern	NNS
cord-310192-8x37nx4s	189	13	,	,	,
cord-310192-8x37nx4s	189	14	because	because	IN
cord-310192-8x37nx4s	189	15	the	the	DT
cord-310192-8x37nx4s	189	16	detection	detection	NN
cord-310192-8x37nx4s	189	17	occurs	occur	VBZ
cord-310192-8x37nx4s	189	18	via	via	IN
cord-310192-8x37nx4s	189	19	nonexchangeable	nonexchangeable	JJ
cord-310192-8x37nx4s	189	20	protons	proton	NNS
cord-310192-8x37nx4s	190	1	(	(	-LRB-
cord-310192-8x37nx4s	190	2	Figure	figure	NN
cord-310192-8x37nx4s	190	3	4	4	CD
cord-310192-8x37nx4s	190	4	)	)	-RRB-
cord-310192-8x37nx4s	191	1	(	(	-LRB-
cord-310192-8x37nx4s	191	2	Dallmann	Dallmann	NNP
cord-310192-8x37nx4s	191	3	et	et	NNP
cord-310192-8x37nx4s	191	4	al	al	NNP
cord-310192-8x37nx4s	191	5	.	.	NNP
cord-310192-8x37nx4s	191	6	,	,	,
cord-310192-8x37nx4s	191	7	2013	2013	CD
cord-310192-8x37nx4s	191	8	)	)	-RRB-
cord-310192-8x37nx4s	191	9	.	.	.
cord-310192-8x37nx4s	192	1	F	F	NNP
cord-310192-8x37nx4s	192	2	I	i	NN
cord-310192-8x37nx4s	192	3	G	g	NN
cord-310192-8x37nx4s	193	1	U	u	NN
cord-310192-8x37nx4s	193	2	R	r	NN
cord-310192-8x37nx4s	193	3	E	e	NN
cord-310192-8x37nx4s	193	4	4	4	CD
cord-310192-8x37nx4s	193	5	Detection	detection	NN
cord-310192-8x37nx4s	193	6	of	of	IN
cord-310192-8x37nx4s	193	7	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	193	8	bonds	bond	NNS
cord-310192-8x37nx4s	193	9	in	in	IN
cord-310192-8x37nx4s	193	10	canonical	canonical	JJ
cord-310192-8x37nx4s	193	11	A	a	NN
cord-310192-8x37nx4s	193	12	-	-	HYPH
cord-310192-8x37nx4s	193	13	U	u	NN
cord-310192-8x37nx4s	193	14	and	and	CC
cord-310192-8x37nx4s	193	15	G	G	NNP
cord-310192-8x37nx4s	193	16	-	-	HYPH
cord-310192-8x37nx4s	193	17	C	c	NN
cord-310192-8x37nx4s	193	18	base	base	NN
cord-310192-8x37nx4s	193	19	pairs	pair	NNS
cord-310192-8x37nx4s	193	20	.	.	.
cord-310192-8x37nx4s	194	1	Traditionally	traditionally	RB
cord-310192-8x37nx4s	194	2	,	,	,
cord-310192-8x37nx4s	194	3	imino	imino	NNP
cord-310192-8x37nx4s	194	4	protons	proton	NNS
cord-310192-8x37nx4s	194	5	(	(	-LRB-
cord-310192-8x37nx4s	194	6	blue	blue	NNP
cord-310192-8x37nx4s	194	7	)	)	-RRB-
cord-310192-8x37nx4s	194	8	are	be	VBP
cord-310192-8x37nx4s	194	9	used	use	VBN
cord-310192-8x37nx4s	194	10	to	to	TO
cord-310192-8x37nx4s	194	11	infer	infer	VB
cord-310192-8x37nx4s	194	12	base	base	NN
cord-310192-8x37nx4s	194	13	pairing	pair	VBG
cord-310192-8x37nx4s	194	14	within	within	IN
cord-310192-8x37nx4s	194	15	helical	helical	JJ
cord-310192-8x37nx4s	194	16	structural	structural	JJ
cord-310192-8x37nx4s	194	17	elements	element	NNS
cord-310192-8x37nx4s	194	18	.	.	.
cord-310192-8x37nx4s	195	1	Improvements	improvement	NNS
cord-310192-8x37nx4s	195	2	to	to	TO
cord-310192-8x37nx4s	195	3	pulse	pulse	VB
cord-310192-8x37nx4s	195	4	sequences	sequence	NNS
cord-310192-8x37nx4s	195	5	,	,	,
cord-310192-8x37nx4s	195	6	implemented	implement	VBN
cord-310192-8x37nx4s	195	7	by	by	IN
cord-310192-8x37nx4s	195	8	the	the	DT
cord-310192-8x37nx4s	195	9	Sattler	Sattler	NNP
cord-310192-8x37nx4s	195	10	lab	lab	NN
cord-310192-8x37nx4s	195	11	,	,	,
cord-310192-8x37nx4s	195	12	allow	allow	VB
cord-310192-8x37nx4s	195	13	for	for	IN
cord-310192-8x37nx4s	195	14	the	the	DT
cord-310192-8x37nx4s	195	15	detection	detection	NN
cord-310192-8x37nx4s	195	16	of	of	IN
cord-310192-8x37nx4s	195	17	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	195	18	-	-	HYPH
cord-310192-8x37nx4s	195	19	bonding	bonding	NN
cord-310192-8x37nx4s	195	20	on	on	IN
cord-310192-8x37nx4s	195	21	nonexchangeable	nonexchangeable	JJ
cord-310192-8x37nx4s	195	22	C	c	NN
cord-310192-8x37nx4s	195	23	2	2	CD
cord-310192-8x37nx4s	195	24	(	(	-LRB-
cord-310192-8x37nx4s	195	25	adenosine	adenosine	NN
cord-310192-8x37nx4s	195	26	)	)	-RRB-
cord-310192-8x37nx4s	195	27	and	and	CC
cord-310192-8x37nx4s	195	28	C	C	NNP
cord-310192-8x37nx4s	195	29	5	5	CD
cord-310192-8x37nx4s	195	30	(	(	-LRB-
cord-310192-8x37nx4s	195	31	cytosine	cytosine	NN
cord-310192-8x37nx4s	195	32	and	and	CC
cord-310192-8x37nx4s	195	33	uracil	uracil	NN
cord-310192-8x37nx4s	195	34	)	)	-RRB-
cord-310192-8x37nx4s	195	35	protons	proton	NNS
cord-310192-8x37nx4s	196	1	(	(	-LRB-
cord-310192-8x37nx4s	196	2	Dallmann	Dallmann	NNP
cord-310192-8x37nx4s	196	3	et	et	NNP
cord-310192-8x37nx4s	196	4	al	al	NNP
cord-310192-8x37nx4s	196	5	.	.	NNP
cord-310192-8x37nx4s	196	6	,	,	,
cord-310192-8x37nx4s	196	7	2013	2013	CD
cord-310192-8x37nx4s	196	8	)	)	-RRB-
cord-310192-8x37nx4s	196	9	.	.	.
cord-310192-8x37nx4s	197	1	Magnetization	magnetization	NN
cord-310192-8x37nx4s	197	2	transfer	transfer	NN
cord-310192-8x37nx4s	197	3	pathways	pathway	NNS
cord-310192-8x37nx4s	197	4	are	be	VBP
cord-310192-8x37nx4s	197	5	indicated	indicate	VBN
cord-310192-8x37nx4s	197	6	with	with	IN
cord-310192-8x37nx4s	197	7	arrows	arrow	NNS
cord-310192-8x37nx4s	197	8	5.2	5.2	CD
cord-310192-8x37nx4s	197	9	|	|	NNP
cord-310192-8x37nx4s	197	10	Global	global	JJ
cord-310192-8x37nx4s	197	11	orientation	orientation	NN
cord-310192-8x37nx4s	197	12	of	of	IN
cord-310192-8x37nx4s	197	13	helical	helical	JJ
cord-310192-8x37nx4s	197	14	elements	element	NNS
cord-310192-8x37nx4s	197	15	Distance	Distance	NNP
cord-310192-8x37nx4s	197	16	restraints	restraint	NNS
cord-310192-8x37nx4s	197	17	(	(	-LRB-
cord-310192-8x37nx4s	197	18	which	which	WDT
cord-310192-8x37nx4s	197	19	are	be	VBP
cord-310192-8x37nx4s	197	20	obtained	obtain	VBN
cord-310192-8x37nx4s	197	21	via	via	IN
cord-310192-8x37nx4s	197	22	the	the	DT
cord-310192-8x37nx4s	197	23	analysis	analysis	NN
cord-310192-8x37nx4s	197	24	of	of	IN
cord-310192-8x37nx4s	197	25	NOE	NOE	NNP
cord-310192-8x37nx4s	197	26	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	197	27	experiments	experiment	NNS
cord-310192-8x37nx4s	197	28	)	)	-RRB-
cord-310192-8x37nx4s	197	29	provide	provide	VBP
cord-310192-8x37nx4s	197	30	high	high	JJ
cord-310192-8x37nx4s	197	31	-	-	HYPH
cord-310192-8x37nx4s	197	32	resolution	resolution	NN
cord-310192-8x37nx4s	197	33	local	local	JJ
cord-310192-8x37nx4s	197	34	structural	structural	JJ
cord-310192-8x37nx4s	197	35	information	information	NN
cord-310192-8x37nx4s	197	36	,	,	,
cord-310192-8x37nx4s	197	37	however	however	RB
cord-310192-8x37nx4s	197	38	can	can	MD
cord-310192-8x37nx4s	197	39	not	not	RB
cord-310192-8x37nx4s	197	40	generally	generally	RB
cord-310192-8x37nx4s	197	41	define	define	VB
cord-310192-8x37nx4s	197	42	the	the	DT
cord-310192-8x37nx4s	197	43	relative	relative	JJ
cord-310192-8x37nx4s	197	44	orientation	orientation	NN
cord-310192-8x37nx4s	197	45	of	of	IN
cord-310192-8x37nx4s	197	46	secondary	secondary	JJ
cord-310192-8x37nx4s	197	47	structure	structure	NN
cord-310192-8x37nx4s	197	48	elements	element	NNS
cord-310192-8x37nx4s	197	49	within	within	IN
cord-310192-8x37nx4s	197	50	a	a	DT
cord-310192-8x37nx4s	197	51	large	large	JJ
cord-310192-8x37nx4s	197	52	RNA	rna	NN
cord-310192-8x37nx4s	197	53	.	.	.
cord-310192-8x37nx4s	198	1	Residual	residual	JJ
cord-310192-8x37nx4s	198	2	dipolar	dipolar	JJ
cord-310192-8x37nx4s	198	3	couplings	coupling	NNS
cord-310192-8x37nx4s	198	4	(	(	-LRB-
cord-310192-8x37nx4s	198	5	RDCs	rdc	NNS
cord-310192-8x37nx4s	198	6	)	)	-RRB-
cord-310192-8x37nx4s	198	7	provide	provide	VB
cord-310192-8x37nx4s	198	8	important	important	JJ
cord-310192-8x37nx4s	198	9	orientation	orientation	NN
cord-310192-8x37nx4s	198	10	restraints	restraint	NNS
cord-310192-8x37nx4s	198	11	and	and	CC
cord-310192-8x37nx4s	198	12	inclusion	inclusion	NN
cord-310192-8x37nx4s	198	13	of	of	IN
cord-310192-8x37nx4s	198	14	these	these	DT
cord-310192-8x37nx4s	198	15	restraints	restraint	NNS
cord-310192-8x37nx4s	198	16	in	in	IN
cord-310192-8x37nx4s	198	17	structure	structure	NN
cord-310192-8x37nx4s	198	18	refinement	refinement	NN
cord-310192-8x37nx4s	198	19	greatly	greatly	RB
cord-310192-8x37nx4s	198	20	improves	improve	VBZ
cord-310192-8x37nx4s	198	21	the	the	DT
cord-310192-8x37nx4s	198	22	overall	overall	JJ
cord-310192-8x37nx4s	198	23	accuracy	accuracy	NN
cord-310192-8x37nx4s	198	24	of	of	IN
cord-310192-8x37nx4s	198	25	the	the	DT
cord-310192-8x37nx4s	198	26	structure	structure	NN
cord-310192-8x37nx4s	198	27	(	(	-LRB-
cord-310192-8x37nx4s	198	28	Bermejo	Bermejo	NNP
cord-310192-8x37nx4s	198	29	,	,	,
cord-310192-8x37nx4s	198	30	Clore	Clore	NNP
cord-310192-8x37nx4s	198	31	,	,	,
cord-310192-8x37nx4s	198	32	&	&	CC
cord-310192-8x37nx4s	198	33	Schwieters	Schwieters	NNPS
cord-310192-8x37nx4s	198	34	,	,	,
cord-310192-8x37nx4s	198	35	2016	2016	CD
cord-310192-8x37nx4s	198	36	)	)	-RRB-
cord-310192-8x37nx4s	198	37	.	.	.
cord-310192-8x37nx4s	199	1	RDC	RDC	NNP
cord-310192-8x37nx4s	199	2	measurements	measurement	NNS
cord-310192-8x37nx4s	199	3	are	be	VBP
cord-310192-8x37nx4s	199	4	conducted	conduct	VBN
cord-310192-8x37nx4s	199	5	both	both	CC
cord-310192-8x37nx4s	199	6	in	in	IN
cord-310192-8x37nx4s	199	7	the	the	DT
cord-310192-8x37nx4s	199	8	absence	absence	NN
cord-310192-8x37nx4s	199	9	and	and	CC
cord-310192-8x37nx4s	199	10	presence	presence	NN
cord-310192-8x37nx4s	199	11	of	of	IN
cord-310192-8x37nx4s	199	12	an	an	DT
cord-310192-8x37nx4s	199	13	alignment	alignment	NN
cord-310192-8x37nx4s	199	14	media	media	NN
cord-310192-8x37nx4s	199	15	(	(	-LRB-
cord-310192-8x37nx4s	199	16	Pf1	pf1	CD
cord-310192-8x37nx4s	199	17	phage	phage	NN
cord-310192-8x37nx4s	199	18	is	be	VBZ
cord-310192-8x37nx4s	199	19	common	common	JJ
cord-310192-8x37nx4s	199	20	for	for	IN
cord-310192-8x37nx4s	199	21	RNA	RNA	NNP
cord-310192-8x37nx4s	199	22	samples	sample	NNS
cord-310192-8x37nx4s	199	23	)	)	-RRB-
cord-310192-8x37nx4s	200	1	(	(	-LRB-
cord-310192-8x37nx4s	200	2	Clore	Clore	NNP
cord-310192-8x37nx4s	200	3	,	,	,
cord-310192-8x37nx4s	200	4	Starich	Starich	NNP
cord-310192-8x37nx4s	200	5	,	,	,
cord-310192-8x37nx4s	200	6	&	&	CC
cord-310192-8x37nx4s	200	7	Gronenborn	Gronenborn	NNP
cord-310192-8x37nx4s	200	8	,	,	,
cord-310192-8x37nx4s	200	9	1998	1998	CD
cord-310192-8x37nx4s	200	10	;	;	:
cord-310192-8x37nx4s	200	11	M.	M.	NNP
cord-310192-8x37nx4s	200	12	R.	R.	NNP
cord-310192-8x37nx4s	200	13	Hansen	Hansen	NNP
cord-310192-8x37nx4s	200	14	,	,	,
cord-310192-8x37nx4s	200	15	Hanson	Hanson	NNP
cord-310192-8x37nx4s	200	16	,	,	,
cord-310192-8x37nx4s	200	17	&	&	CC
cord-310192-8x37nx4s	200	18	Pardi	Pardi	NNP
cord-310192-8x37nx4s	200	19	,	,	,
cord-310192-8x37nx4s	200	20	2000	2000	CD
cord-310192-8x37nx4s	200	21	)	)	-RRB-
cord-310192-8x37nx4s	200	22	,	,	,
cord-310192-8x37nx4s	200	23	and	and	CC
cord-310192-8x37nx4s	200	24	are	be	VBP
cord-310192-8x37nx4s	200	25	measured	measure	VBN
cord-310192-8x37nx4s	200	26	on	on	IN
cord-310192-8x37nx4s	200	27	a	a	DT
cord-310192-8x37nx4s	200	28	variety	variety	NN
cord-310192-8x37nx4s	200	29	of	of	IN
cord-310192-8x37nx4s	200	30	carbon	carbon	NN
cord-310192-8x37nx4s	200	31	-	-	HYPH
cord-310192-8x37nx4s	200	32	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	200	33	and/or	and/or	CC
cord-310192-8x37nx4s	200	34	nitrogen	nitrogen	NN
cord-310192-8x37nx4s	200	35	-	-	HYPH
cord-310192-8x37nx4s	200	36	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	200	37	correlations	correlation	NNS
cord-310192-8x37nx4s	200	38	within	within	IN
cord-310192-8x37nx4s	200	39	the	the	DT
cord-310192-8x37nx4s	200	40	base	base	NN
cord-310192-8x37nx4s	200	41	and	and	CC
cord-310192-8x37nx4s	200	42	ribose	ribose	NN
cord-310192-8x37nx4s	200	43	(	(	-LRB-
cord-310192-8x37nx4s	200	44	M.	M.	NNP
cord-310192-8x37nx4s	200	45	R.	R.	NNP
cord-310192-8x37nx4s	200	46	Hansen	Hansen	NNP
cord-310192-8x37nx4s	200	47	,	,	,
cord-310192-8x37nx4s	200	48	Mueller	Mueller	NNP
cord-310192-8x37nx4s	200	49	,	,	,
cord-310192-8x37nx4s	200	50	&	&	CC
cord-310192-8x37nx4s	200	51	Pardi	Pardi	NNP
cord-310192-8x37nx4s	200	52	,	,	,
cord-310192-8x37nx4s	200	53	1998	1998	CD
cord-310192-8x37nx4s	200	54	;	;	:
cord-310192-8x37nx4s	200	55	Yan	Yan	NNP
cord-310192-8x37nx4s	200	56	,	,	,
cord-310192-8x37nx4s	200	57	Corpora	Corpora	NNP
cord-310192-8x37nx4s	200	58	,	,	,
cord-310192-8x37nx4s	200	59	Pradhan	Pradhan	NNP
cord-310192-8x37nx4s	200	60	,	,	,
cord-310192-8x37nx4s	200	61	&	&	CC
cord-310192-8x37nx4s	200	62	Bushweller	Bushweller	NNP
cord-310192-8x37nx4s	200	63	,	,	,
cord-310192-8x37nx4s	200	64	2002	2002	CD
cord-310192-8x37nx4s	200	65	;	;	:
cord-310192-8x37nx4s	200	66	Zidek	Zidek	NNP
cord-310192-8x37nx4s	200	67	,	,	,
cord-310192-8x37nx4s	200	68	Wu	Wu	NNP
cord-310192-8x37nx4s	200	69	,	,	,
cord-310192-8x37nx4s	200	70	Feigon	Feigon	NNP
cord-310192-8x37nx4s	200	71	,	,	,
cord-310192-8x37nx4s	200	72	&	&	CC
cord-310192-8x37nx4s	200	73	Sklenar	Sklenar	NNP
cord-310192-8x37nx4s	200	74	,	,	,
cord-310192-8x37nx4s	200	75	2001	2001	CD
cord-310192-8x37nx4s	200	76	)	)	-RRB-
cord-310192-8x37nx4s	200	77	.	.	.
cord-310192-8x37nx4s	201	1	RDCs	rdc	NNS
cord-310192-8x37nx4s	201	2	provide	provide	VBP
cord-310192-8x37nx4s	201	3	important	important	JJ
cord-310192-8x37nx4s	201	4	restraints	restraint	NNS
cord-310192-8x37nx4s	201	5	in	in	IN
cord-310192-8x37nx4s	201	6	RNA	RNA	NNP
cord-310192-8x37nx4s	201	7	structure	structure	NN
cord-310192-8x37nx4s	201	8	determination	determination	NN
cord-310192-8x37nx4s	201	9	;	;	:
cord-310192-8x37nx4s	201	10	however	however	RB
cord-310192-8x37nx4s	201	11	,	,	,
cord-310192-8x37nx4s	201	12	slightly	slightly	RB
cord-310192-8x37nx4s	201	13	fewer	few	JJR
cord-310192-8x37nx4s	201	14	than	than	IN
cord-310192-8x37nx4s	201	15	half	half	NN
cord-310192-8x37nx4s	201	16	of	of	IN
cord-310192-8x37nx4s	201	17	NMR	nmr	NN
cord-310192-8x37nx4s	201	18	-	-	HYPH
cord-310192-8x37nx4s	201	19	derived	derive	VBN
cord-310192-8x37nx4s	201	20	medium	medium	NN
cord-310192-8x37nx4s	201	21	to	to	IN
cord-310192-8x37nx4s	201	22	large	large	JJ
cord-310192-8x37nx4s	201	23	RNA	RNA	NNP
cord-310192-8x37nx4s	201	24	structures	structure	NNS
cord-310192-8x37nx4s	201	25	(	(	-LRB-
cord-310192-8x37nx4s	201	26	RNAs	rna	NNS
cord-310192-8x37nx4s	201	27	larger	large	JJR
cord-310192-8x37nx4s	201	28	than	than	IN
cord-310192-8x37nx4s	201	29	50	50	CD
cord-310192-8x37nx4s	201	30	nt	nt	RB
cord-310192-8x37nx4s	201	31	)	)	-RRB-
cord-310192-8x37nx4s	201	32	used	use	VBD
cord-310192-8x37nx4s	201	33	RDC	RDC	NNP
cord-310192-8x37nx4s	201	34	measurements	measurement	NNS
cord-310192-8x37nx4s	201	35	in	in	IN
cord-310192-8x37nx4s	201	36	structure	structure	NN
cord-310192-8x37nx4s	201	37	refinement	refinement	NN
cord-310192-8x37nx4s	201	38	(	(	-LRB-
cord-310192-8x37nx4s	202	1	Au	Au	NNP
cord-310192-8x37nx4s	202	2	et	et	NNP
cord-310192-8x37nx4s	202	3	al	al	NNP
cord-310192-8x37nx4s	202	4	.	.	NNP
cord-310192-8x37nx4s	202	5	,	,	,
cord-310192-8x37nx4s	202	6	2015	2015	CD
cord-310192-8x37nx4s	203	1	;	;	:
cord-310192-8x37nx4s	203	2	Barnwal	Barnwal	NNP
cord-310192-8x37nx4s	203	3	et	et	NNP
cord-310192-8x37nx4s	203	4	al	al	NNP
cord-310192-8x37nx4s	203	5	.	.	NNP
cord-310192-8x37nx4s	203	6	,	,	,
cord-310192-8x37nx4s	203	7	2016	2016	CD
cord-310192-8x37nx4s	203	8	;	;	:
cord-310192-8x37nx4s	203	9	Burke	Burke	NNP
cord-310192-8x37nx4s	203	10	et	et	NNP
cord-310192-8x37nx4s	203	11	al	al	NNP
cord-310192-8x37nx4s	203	12	.	.	.
cord-310192-8x37nx4s	204	1	,	,	,
cord-310192-8x37nx4s	204	2	2012	2012	CD
cord-310192-8x37nx4s	204	3	;	;	:
cord-310192-8x37nx4s	204	4	Cornilescu	Cornilescu	NNP
cord-310192-8x37nx4s	204	5	et	et	FW
cord-310192-8x37nx4s	204	6	al	al	NNP
cord-310192-8x37nx4s	204	7	.	.	NNP
cord-310192-8x37nx4s	204	8	,	,	,
cord-310192-8x37nx4s	204	9	2016	2016	CD
cord-310192-8x37nx4s	204	10	;	;	:
cord-310192-8x37nx4s	204	11	Davis	Davis	NNP
cord-310192-8x37nx4s	204	12	et	et	NNP
cord-310192-8x37nx4s	204	13	al	al	NNP
cord-310192-8x37nx4s	204	14	.	.	.
cord-310192-8x37nx4s	205	1	,	,	,
cord-310192-8x37nx4s	205	2	2005	2005	CD
cord-310192-8x37nx4s	205	3	;	;	:
cord-310192-8x37nx4s	205	4	Houck	Houck	NNP
cord-310192-8x37nx4s	205	5	-	-	HYPH
cord-310192-8x37nx4s	205	6	Loomis	Loomis	NNP
cord-310192-8x37nx4s	205	7	et	et	NNP
cord-310192-8x37nx4s	205	8	al	al	NNP
cord-310192-8x37nx4s	205	9	.	.	NNP
cord-310192-8x37nx4s	205	10	,	,	,
cord-310192-8x37nx4s	205	11	2011	2011	CD
cord-310192-8x37nx4s	205	12	;	;	:
cord-310192-8x37nx4s	205	13	Jain	Jain	NNP
cord-310192-8x37nx4s	205	14	,	,	,
cord-310192-8x37nx4s	205	15	Morgan	Morgan	NNP
cord-310192-8x37nx4s	205	16	,	,	,
cord-310192-8x37nx4s	205	17	Rife	Rife	NNP
cord-310192-8x37nx4s	205	18	,	,	,
cord-310192-8x37nx4s	205	19	Salemi	Salemi	NNP
cord-310192-8x37nx4s	205	20	,	,	,
cord-310192-8x37nx4s	205	21	&	&	CC
cord-310192-8x37nx4s	205	22	Tolbert	Tolbert	NNP
cord-310192-8x37nx4s	205	23	,	,	,
cord-310192-8x37nx4s	205	24	2016	2016	CD
cord-310192-8x37nx4s	205	25	;	;	:
cord-310192-8x37nx4s	205	26	Kang	Kang	NNP
cord-310192-8x37nx4s	205	27	,	,	,
cord-310192-8x37nx4s	205	28	Eichhorn	Eichhorn	NNP
cord-310192-8x37nx4s	205	29	,	,	,
cord-310192-8x37nx4s	205	30	&	&	CC
cord-310192-8x37nx4s	205	31	Feigon	Feigon	NNP
cord-310192-8x37nx4s	205	32	,	,	,
cord-310192-8x37nx4s	205	33	2014	2014	CD
cord-310192-8x37nx4s	205	34	;	;	:
cord-310192-8x37nx4s	205	35	N.	N.	NNP
cord-310192-8x37nx4s	205	36	K.	K.	NNP
cord-310192-8x37nx4s	205	37	Kim	Kim	NNP
cord-310192-8x37nx4s	205	38	,	,	,
cord-310192-8x37nx4s	205	39	Zhang	Zhang	NNP
cord-310192-8x37nx4s	205	40	,	,	,
cord-310192-8x37nx4s	205	41	&	&	CC
cord-310192-8x37nx4s	205	42	Feigon	Feigon	NNP
cord-310192-8x37nx4s	205	43	,	,	,
cord-310192-8x37nx4s	205	44	2014	2014	CD
cord-310192-8x37nx4s	205	45	;	;	:
cord-310192-8x37nx4s	205	46	Lukavsky	Lukavsky	NNP
cord-310192-8x37nx4s	205	47	,	,	,
cord-310192-8x37nx4s	205	48	Kim	Kim	NNP
cord-310192-8x37nx4s	205	49	,	,	,
cord-310192-8x37nx4s	205	50	Otto	Otto	NNP
cord-310192-8x37nx4s	205	51	,	,	,
cord-310192-8x37nx4s	205	52	&	&	CC
cord-310192-8x37nx4s	205	53	Puglisi	Puglisi	NNP
cord-310192-8x37nx4s	205	54	,	,	,
cord-310192-8x37nx4s	205	55	2003	2003	CD
cord-310192-8x37nx4s	205	56	;	;	:
cord-310192-8x37nx4s	205	57	Lukavsky	Lukavsky	NNP
cord-310192-8x37nx4s	205	58	&	&	CC
cord-310192-8x37nx4s	205	59	Puglisi	Puglisi	NNP
cord-310192-8x37nx4s	205	60	,	,	,
cord-310192-8x37nx4s	205	61	2005	2005	CD
cord-310192-8x37nx4s	205	62	;	;	:
cord-310192-8x37nx4s	205	63	Miller	Miller	NNP
cord-310192-8x37nx4s	205	64	et	et	NNP
cord-310192-8x37nx4s	205	65	al	al	NNP
cord-310192-8x37nx4s	205	66	.	.	NNP
cord-310192-8x37nx4s	205	67	,	,	,
cord-310192-8x37nx4s	205	68	2014	2014	CD
cord-310192-8x37nx4s	205	69	;	;	:
cord-310192-8x37nx4s	205	70	Ulyanov	Ulyanov	NNP
cord-310192-8x37nx4s	205	71	et	et	NNP
cord-310192-8x37nx4s	205	72	al	al	NNP
cord-310192-8x37nx4s	205	73	.	.	NNP
cord-310192-8x37nx4s	205	74	,	,	,
cord-310192-8x37nx4s	205	75	2006	2006	CD
cord-310192-8x37nx4s	205	76	)	)	-RRB-
cord-310192-8x37nx4s	205	77	.	.	.
cord-310192-8x37nx4s	206	1	The	the	DT
cord-310192-8x37nx4s	206	2	incorporation	incorporation	NN
cord-310192-8x37nx4s	206	3	of	of	IN
cord-310192-8x37nx4s	206	4	13	13	CD
cord-310192-8x37nx4s	206	5	C	c	NN
cord-310192-8x37nx4s	206	6	into	into	IN
cord-310192-8x37nx4s	206	7	large	large	JJ
cord-310192-8x37nx4s	206	8	RNAs	rna	NNS
cord-310192-8x37nx4s	206	9	results	result	NNS
cord-310192-8x37nx4s	206	10	in	in	IN
cord-310192-8x37nx4s	206	11	severe	severe	JJ
cord-310192-8x37nx4s	206	12	line	line	NN
cord-310192-8x37nx4s	206	13	broadening	broadening	NN
cord-310192-8x37nx4s	206	14	,	,	,
cord-310192-8x37nx4s	206	15	limiting	limit	VBG
cord-310192-8x37nx4s	206	16	the	the	DT
cord-310192-8x37nx4s	206	17	usefulness	usefulness	NN
cord-310192-8x37nx4s	206	18	of	of	IN
cord-310192-8x37nx4s	206	19	this	this	DT
cord-310192-8x37nx4s	206	20	approach	approach	NN
cord-310192-8x37nx4s	206	21	for	for	IN
cord-310192-8x37nx4s	206	22	the	the	DT
cord-310192-8x37nx4s	206	23	study	study	NN
cord-310192-8x37nx4s	206	24	of	of	IN
cord-310192-8x37nx4s	206	25	larger	large	JJR
cord-310192-8x37nx4s	206	26	RNAs	rna	NNS
cord-310192-8x37nx4s	206	27	.	.	.
cord-310192-8x37nx4s	207	1	Marchant	Marchant	NNP
cord-310192-8x37nx4s	207	2	et	et	NNP
cord-310192-8x37nx4s	207	3	al	al	NNP
cord-310192-8x37nx4s	207	4	.	.	NNP
cord-310192-8x37nx4s	207	5	developed	develop	VBD
cord-310192-8x37nx4s	207	6	a	a	DT
cord-310192-8x37nx4s	207	7	new	new	JJ
cord-310192-8x37nx4s	207	8	method	method	NN
cord-310192-8x37nx4s	207	9	for	for	IN
cord-310192-8x37nx4s	207	10	recording	record	VBG
cord-310192-8x37nx4s	207	11	RDC	RDC	NNP
cord-310192-8x37nx4s	207	12	measurements	measurement	NNS
cord-310192-8x37nx4s	207	13	in	in	IN
cord-310192-8x37nx4s	207	14	large	large	JJ
cord-310192-8x37nx4s	207	15	RNAs	rna	NNS
cord-310192-8x37nx4s	207	16	that	that	WDT
cord-310192-8x37nx4s	207	17	capitalizes	capitalize	VBZ
cord-310192-8x37nx4s	207	18	on	on	IN
cord-310192-8x37nx4s	207	19	the	the	DT
cord-310192-8x37nx4s	207	20	large	large	JJ
cord-310192-8x37nx4s	207	21	chemical	chemical	JJ
cord-310192-8x37nx4s	207	22	shift	shift	NN
cord-310192-8x37nx4s	207	23	dispersion	dispersion	NN
cord-310192-8x37nx4s	207	24	and	and	CC
cord-310192-8x37nx4s	207	25	narrow	narrow	JJ
cord-310192-8x37nx4s	207	26	line	line	NN
cord-310192-8x37nx4s	207	27	widths	width	NNS
cord-310192-8x37nx4s	207	28	of	of	IN
cord-310192-8x37nx4s	207	29	adenosine	adenosine	NN
cord-310192-8x37nx4s	207	30	C	C	NNP
cord-310192-8x37nx4s	207	31	2	2	CD
cord-310192-8x37nx4s	207	32	protons	proton	NNS
cord-310192-8x37nx4s	207	33	(	(	-LRB-
cord-310192-8x37nx4s	207	34	Marchant	Marchant	NNP
cord-310192-8x37nx4s	207	35	et	et	NNP
cord-310192-8x37nx4s	207	36	al	al	NNP
cord-310192-8x37nx4s	207	37	.	.	NNP
cord-310192-8x37nx4s	207	38	,	,	,
cord-310192-8x37nx4s	207	39	2018	2018	CD
cord-310192-8x37nx4s	207	40	)	)	-RRB-
cord-310192-8x37nx4s	207	41	.	.	.
cord-310192-8x37nx4s	208	1	This	this	DT
cord-310192-8x37nx4s	208	2	method	method	NN
cord-310192-8x37nx4s	208	3	requires	require	VBZ
cord-310192-8x37nx4s	208	4	the	the	DT
cord-310192-8x37nx4s	208	5	preparation	preparation	NN
cord-310192-8x37nx4s	208	6	of	of	IN
cord-310192-8x37nx4s	208	7	RNA	RNA	NNP
cord-310192-8x37nx4s	208	8	with	with	IN
cord-310192-8x37nx4s	208	9	15	15	CD
cord-310192-8x37nx4s	208	10	N	n	CD
cord-310192-8x37nx4s	208	11	-	-	HYPH
cord-310192-8x37nx4s	208	12	adenosine	adenosine	NN
cord-310192-8x37nx4s	208	13	and	and	CC
cord-310192-8x37nx4s	208	14	uses	use	VBZ
cord-310192-8x37nx4s	208	15	a	a	DT
cord-310192-8x37nx4s	208	16	variable	variable	JJ
cord-310192-8x37nx4s	208	17	flip	flip	NN
cord-310192-8x37nx4s	208	18	angle	angle	NN
cord-310192-8x37nx4s	208	19	HMQC	HMQC	NNS
cord-310192-8x37nx4s	208	20	to	to	TO
cord-310192-8x37nx4s	208	21	obtain	obtain	VB
cord-310192-8x37nx4s	208	22	RDC	RDC	NNP
cord-310192-8x37nx4s	208	23	measurements	measurement	NNS
cord-310192-8x37nx4s	208	24	and	and	CC
cord-310192-8x37nx4s	208	25	was	be	VBD
cord-310192-8x37nx4s	208	26	applied	apply	VBN
cord-310192-8x37nx4s	208	27	to	to	IN
cord-310192-8x37nx4s	208	28	the	the	DT
cord-310192-8x37nx4s	208	29	study	study	NN
cord-310192-8x37nx4s	208	30	of	of	IN
cord-310192-8x37nx4s	208	31	a	a	DT
cord-310192-8x37nx4s	208	32	232	232	CD
cord-310192-8x37nx4s	208	33	nt	nt	RB
cord-310192-8x37nx4s	208	34	element	element	NN
cord-310192-8x37nx4s	208	35	corresponding	correspond	VBG
cord-310192-8x37nx4s	208	36	to	to	IN
cord-310192-8x37nx4s	208	37	the	the	DT
cord-310192-8x37nx4s	208	38	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	208	39	Reve	Reve	NNP
cord-310192-8x37nx4s	208	40	response	response	NN
cord-310192-8x37nx4s	208	41	element	element	NN
cord-310192-8x37nx4s	208	42	(	(	-LRB-
cord-310192-8x37nx4s	208	43	Marchant	Marchant	NNP
cord-310192-8x37nx4s	208	44	et	et	NNP
cord-310192-8x37nx4s	208	45	al	al	NNP
cord-310192-8x37nx4s	208	46	.	.	NNP
cord-310192-8x37nx4s	208	47	,	,	,
cord-310192-8x37nx4s	208	48	2018	2018	CD
cord-310192-8x37nx4s	208	49	)	)	-RRB-
cord-310192-8x37nx4s	208	50	.	.	.
cord-310192-8x37nx4s	209	1	Dynamic	dynamic	JJ
cord-310192-8x37nx4s	209	2	conformational	conformational	JJ
cord-310192-8x37nx4s	209	3	exchange	exchange	NN
cord-310192-8x37nx4s	209	4	is	be	VBZ
cord-310192-8x37nx4s	209	5	important	important	JJ
cord-310192-8x37nx4s	209	6	for	for	IN
cord-310192-8x37nx4s	209	7	the	the	DT
cord-310192-8x37nx4s	209	8	function	function	NN
cord-310192-8x37nx4s	209	9	of	of	IN
cord-310192-8x37nx4s	209	10	regulatory	regulatory	JJ
cord-310192-8x37nx4s	209	11	RNAs	rna	NNS
cord-310192-8x37nx4s	209	12	in	in	IN
cord-310192-8x37nx4s	209	13	molecular	molecular	JJ
cord-310192-8x37nx4s	209	14	processes	process	NNS
cord-310192-8x37nx4s	210	1	(	(	-LRB-
cord-310192-8x37nx4s	210	2	Al	Al	NNP
cord-310192-8x37nx4s	210	3	-	-	HYPH
cord-310192-8x37nx4s	210	4	Hashimi	Hashimi	NNP
cord-310192-8x37nx4s	210	5	&	&	CC
cord-310192-8x37nx4s	210	6	Walter	Walter	NNP
cord-310192-8x37nx4s	210	7	,	,	,
cord-310192-8x37nx4s	210	8	2008	2008	CD
cord-310192-8x37nx4s	210	9	;	;	:
cord-310192-8x37nx4s	210	10	Dethoff	Dethoff	NNP
cord-310192-8x37nx4s	210	11	,	,	,
cord-310192-8x37nx4s	210	12	Chugh	Chugh	NNP
cord-310192-8x37nx4s	210	13	,	,	,
cord-310192-8x37nx4s	210	14	Mustoe	Mustoe	NNP
cord-310192-8x37nx4s	210	15	,	,	,
cord-310192-8x37nx4s	210	16	&	&	CC
cord-310192-8x37nx4s	210	17	Al	Al	NNP
cord-310192-8x37nx4s	210	18	-	-	HYPH
cord-310192-8x37nx4s	210	19	Hashimi	Hashimi	NNP
cord-310192-8x37nx4s	210	20	,	,	,
cord-310192-8x37nx4s	210	21	2012	2012	CD
cord-310192-8x37nx4s	210	22	;	;	:
cord-310192-8x37nx4s	210	23	Xue	Xue	NNP
cord-310192-8x37nx4s	210	24	et	et	NNP
cord-310192-8x37nx4s	210	25	al	al	NNP
cord-310192-8x37nx4s	210	26	.	.	NNP
cord-310192-8x37nx4s	210	27	,	,	,
cord-310192-8x37nx4s	210	28	2015	2015	CD
cord-310192-8x37nx4s	210	29	)	)	-RRB-
cord-310192-8x37nx4s	210	30	.	.	.
cord-310192-8x37nx4s	211	1	One	one	CD
cord-310192-8x37nx4s	211	2	major	major	JJ
cord-310192-8x37nx4s	211	3	strength	strength	NN
cord-310192-8x37nx4s	211	4	of	of	IN
cord-310192-8x37nx4s	211	5	NMR	NMR	NNP
cord-310192-8x37nx4s	211	6	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	211	7	is	be	VBZ
cord-310192-8x37nx4s	211	8	the	the	DT
cord-310192-8x37nx4s	211	9	ability	ability	NN
cord-310192-8x37nx4s	211	10	to	to	TO
cord-310192-8x37nx4s	211	11	capture	capture	VB
cord-310192-8x37nx4s	211	12	dynamics	dynamic	NNS
cord-310192-8x37nx4s	211	13	information	information	NN
cord-310192-8x37nx4s	211	14	,	,	,
cord-310192-8x37nx4s	211	15	reporting	report	VBG
cord-310192-8x37nx4s	211	16	on	on	IN
cord-310192-8x37nx4s	211	17	the	the	DT
cord-310192-8x37nx4s	211	18	local	local	JJ
cord-310192-8x37nx4s	211	19	conformational	conformational	JJ
cord-310192-8x37nx4s	211	20	fluctuations	fluctuation	NNS
cord-310192-8x37nx4s	211	21	at	at	IN
cord-310192-8x37nx4s	211	22	single	single	JJ
cord-310192-8x37nx4s	211	23	nucleotide	nucleotide	JJ
cord-310192-8x37nx4s	211	24	resolution	resolution	NN
cord-310192-8x37nx4s	211	25	(	(	-LRB-
cord-310192-8x37nx4s	211	26	Bothe	bothe	FW
cord-310192-8x37nx4s	211	27	et	et	FW
cord-310192-8x37nx4s	211	28	al	al	NNP
cord-310192-8x37nx4s	211	29	.	.	NNP
cord-310192-8x37nx4s	211	30	,	,	,
cord-310192-8x37nx4s	211	31	2011	2011	CD
cord-310192-8x37nx4s	211	32	;	;	:
cord-310192-8x37nx4s	211	33	.	.	.
cord-310192-8x37nx4s	212	1	Conformational	Conformational	NNP
cord-310192-8x37nx4s	212	2	dynamics	dynamic	NNS
cord-310192-8x37nx4s	212	3	of	of	IN
cord-310192-8x37nx4s	212	4	macromolecules	macromolecule	NNS
cord-310192-8x37nx4s	212	5	occurs	occur	VBZ
cord-310192-8x37nx4s	212	6	over	over	IN
cord-310192-8x37nx4s	212	7	a	a	DT
cord-310192-8x37nx4s	212	8	broad	broad	JJ
cord-310192-8x37nx4s	212	9	range	range	NN
cord-310192-8x37nx4s	212	10	of	of	IN
cord-310192-8x37nx4s	212	11	time	time	NN
cord-310192-8x37nx4s	212	12	scale	scale	NN
cord-310192-8x37nx4s	212	13	,	,	,
cord-310192-8x37nx4s	212	14	from	from	IN
cord-310192-8x37nx4s	212	15	picosecond	picosecond	NN
cord-310192-8x37nx4s	212	16	to	to	IN
cord-310192-8x37nx4s	212	17	second	second	JJ
cord-310192-8x37nx4s	212	18	,	,	,
cord-310192-8x37nx4s	212	19	and	and	CC
cord-310192-8x37nx4s	212	20	formation	formation	NN
cord-310192-8x37nx4s	212	21	of	of	IN
cord-310192-8x37nx4s	212	22	new	new	JJ
cord-310192-8x37nx4s	212	23	base	base	NN
cord-310192-8x37nx4s	212	24	pairs	pair	NNS
cord-310192-8x37nx4s	212	25	in	in	IN
cord-310192-8x37nx4s	212	26	RNA	RNA	NNP
cord-310192-8x37nx4s	212	27	conformational	conformational	JJ
cord-310192-8x37nx4s	212	28	exchange	exchange	NN
cord-310192-8x37nx4s	212	29	lies	lie	NNS
cord-310192-8x37nx4s	212	30	in	in	IN
cord-310192-8x37nx4s	212	31	the	the	DT
cord-310192-8x37nx4s	212	32	scale	scale	NN
cord-310192-8x37nx4s	212	33	of	of	IN
cord-310192-8x37nx4s	212	34	microsecond	microsecond	NN
cord-310192-8x37nx4s	212	35	to	to	IN
cord-310192-8x37nx4s	212	36	second	second	NN
cord-310192-8x37nx4s	213	1	(	(	-LRB-
cord-310192-8x37nx4s	213	2	Bothe	Bothe	NNP
cord-310192-8x37nx4s	213	3	et	et	FW
cord-310192-8x37nx4s	213	4	al	al	NNP
cord-310192-8x37nx4s	213	5	.	.	NNP
cord-310192-8x37nx4s	213	6	,	,	,
cord-310192-8x37nx4s	213	7	2011	2011	CD
cord-310192-8x37nx4s	213	8	;	;	:
cord-310192-8x37nx4s	214	1	Rinnenthal	Rinnenthal	NNP
cord-310192-8x37nx4s	214	2	et	et	NNP
cord-310192-8x37nx4s	214	3	al	al	NNP
cord-310192-8x37nx4s	214	4	.	.	NNP
cord-310192-8x37nx4s	214	5	,	,	,
cord-310192-8x37nx4s	214	6	2011	2011	CD
cord-310192-8x37nx4s	214	7	)	)	-RRB-
cord-310192-8x37nx4s	214	8	.	.	.
cord-310192-8x37nx4s	215	1	Numerous	numerous	JJ
cord-310192-8x37nx4s	215	2	NMR	NMR	NNP
cord-310192-8x37nx4s	215	3	methods	method	NNS
cord-310192-8x37nx4s	215	4	have	have	VBP
cord-310192-8x37nx4s	215	5	been	be	VBN
cord-310192-8x37nx4s	215	6	developed	develop	VBN
cord-310192-8x37nx4s	215	7	to	to	TO
cord-310192-8x37nx4s	215	8	investigate	investigate	VB
cord-310192-8x37nx4s	215	9	biomolecular	biomolecular	JJ
cord-310192-8x37nx4s	215	10	dynamics	dynamic	NNS
cord-310192-8x37nx4s	215	11	at	at	IN
cord-310192-8x37nx4s	215	12	different	different	JJ
cord-310192-8x37nx4s	215	13	time	time	NN
cord-310192-8x37nx4s	215	14	scales	scale	NNS
cord-310192-8x37nx4s	215	15	(	(	-LRB-
cord-310192-8x37nx4s	215	16	Bailor	Bailor	NNP
cord-310192-8x37nx4s	215	17	et	et	NNP
cord-310192-8x37nx4s	215	18	al	al	NNP
cord-310192-8x37nx4s	215	19	.	.	NNP
cord-310192-8x37nx4s	215	20	,	,	,
cord-310192-8x37nx4s	215	21	2007	2007	CD
cord-310192-8x37nx4s	215	22	;	;	:
cord-310192-8x37nx4s	215	23	Kloiber	Kloiber	NNP
cord-310192-8x37nx4s	215	24	,	,	,
cord-310192-8x37nx4s	215	25	Spitzer	Spitzer	NNP
cord-310192-8x37nx4s	215	26	,	,	,
cord-310192-8x37nx4s	215	27	Tollinger	Tollinger	NNP
cord-310192-8x37nx4s	215	28	,	,	,
cord-310192-8x37nx4s	215	29	Konrat	Konrat	NNP
cord-310192-8x37nx4s	215	30	,	,	,
cord-310192-8x37nx4s	215	31	&	&	CC
cord-310192-8x37nx4s	215	32	Kreutz	Kreutz	NNP
cord-310192-8x37nx4s	215	33	,	,	,
cord-310192-8x37nx4s	215	34	2011	2011	CD
cord-310192-8x37nx4s	215	35	;	;	:
cord-310192-8x37nx4s	215	36	Vallurupalli	Vallurupalli	NNP
cord-310192-8x37nx4s	215	37	,	,	,
cord-310192-8x37nx4s	215	38	Sekhar	Sekhar	NNP
cord-310192-8x37nx4s	215	39	,	,	,
cord-310192-8x37nx4s	215	40	Yuwen	Yuwen	NNP
cord-310192-8x37nx4s	215	41	,	,	,
cord-310192-8x37nx4s	215	42	&	&	CC
cord-310192-8x37nx4s	215	43	Kay	Kay	NNP
cord-310192-8x37nx4s	215	44	,	,	,
cord-310192-8x37nx4s	215	45	2017	2017	CD
cord-310192-8x37nx4s	215	46	;	;	:
cord-310192-8x37nx4s	215	47	B.	B.	NNP
cord-310192-8x37nx4s	215	48	Zhao	Zhao	NNP
cord-310192-8x37nx4s	215	49	,	,	,
cord-310192-8x37nx4s	215	50	Hansen	Hansen	NNP
cord-310192-8x37nx4s	215	51	,	,	,
cord-310192-8x37nx4s	215	52	&	&	CC
cord-310192-8x37nx4s	215	53	Zhang	Zhang	NNP
cord-310192-8x37nx4s	215	54	,	,	,
cord-310192-8x37nx4s	215	55	2014	2014	CD
cord-310192-8x37nx4s	215	56	)	)	-RRB-
cord-310192-8x37nx4s	215	57	.	.	.
cord-310192-8x37nx4s	216	1	Here	here	RB
cord-310192-8x37nx4s	216	2	,	,	,
cord-310192-8x37nx4s	216	3	we	-PRON-	PRP
cord-310192-8x37nx4s	216	4	will	will	MD
cord-310192-8x37nx4s	216	5	highlight	highlight	VB
cord-310192-8x37nx4s	216	6	three	three	CD
cord-310192-8x37nx4s	216	7	approaches	approach	NNS
cord-310192-8x37nx4s	216	8	for	for	IN
cord-310192-8x37nx4s	216	9	the	the	DT
cord-310192-8x37nx4s	216	10	quantification	quantification	NN
cord-310192-8x37nx4s	216	11	of	of	IN
cord-310192-8x37nx4s	216	12	conformational	conformational	JJ
cord-310192-8x37nx4s	216	13	dynamic	dynamic	JJ
cord-310192-8x37nx4s	216	14	exchange	exchange	NN
cord-310192-8x37nx4s	216	15	in	in	IN
cord-310192-8x37nx4s	216	16	RNA	RNA	NNP
cord-310192-8x37nx4s	216	17	molecules	molecule	NNS
cord-310192-8x37nx4s	216	18	.	.	.
cord-310192-8x37nx4s	217	1	The	the	DT
cord-310192-8x37nx4s	217	2	chemical	chemical	JJ
cord-310192-8x37nx4s	217	3	shift	shift	NN
cord-310192-8x37nx4s	217	4	saturation	saturation	NN
cord-310192-8x37nx4s	217	5	transfer	transfer	NN
cord-310192-8x37nx4s	217	6	(	(	-LRB-
cord-310192-8x37nx4s	217	7	CEST	CEST	NNP
cord-310192-8x37nx4s	217	8	)	)	-RRB-
cord-310192-8x37nx4s	217	9	NMR	NMR	NNP
cord-310192-8x37nx4s	217	10	experiments	experiment	NNS
cord-310192-8x37nx4s	217	11	,	,	,
cord-310192-8x37nx4s	217	12	which	which	WDT
cord-310192-8x37nx4s	217	13	utilize	utilize	VBP
cord-310192-8x37nx4s	217	14	magnetization	magnetization	NN
cord-310192-8x37nx4s	217	15	"	"	``
cord-310192-8x37nx4s	217	16	interaction	interaction	NN
cord-310192-8x37nx4s	217	17	"	"	''
cord-310192-8x37nx4s	217	18	of	of	IN
cord-310192-8x37nx4s	217	19	one	one	CD
cord-310192-8x37nx4s	217	20	state	state	NN
cord-310192-8x37nx4s	217	21	with	with	IN
cord-310192-8x37nx4s	217	22	another	another	DT
cord-310192-8x37nx4s	217	23	state	state	NN
cord-310192-8x37nx4s	217	24	of	of	IN
cord-310192-8x37nx4s	217	25	molecules	molecule	NNS
cord-310192-8x37nx4s	217	26	,	,	,
cord-310192-8x37nx4s	217	27	has	have	VBZ
cord-310192-8x37nx4s	217	28	been	be	VBN
cord-310192-8x37nx4s	217	29	developed	develop	VBN
cord-310192-8x37nx4s	217	30	to	to	TO
cord-310192-8x37nx4s	217	31	look	look	VB
cord-310192-8x37nx4s	217	32	into	into	IN
cord-310192-8x37nx4s	217	33	slow	slow	JJ
cord-310192-8x37nx4s	217	34	conformational	conformational	JJ
cord-310192-8x37nx4s	217	35	exchange	exchange	NN
cord-310192-8x37nx4s	217	36	of	of	IN
cord-310192-8x37nx4s	217	37	biomolecules	biomolecule	NNS
cord-310192-8x37nx4s	217	38	(	(	-LRB-
cord-310192-8x37nx4s	217	39	reviewed	review	VBN
cord-310192-8x37nx4s	217	40	in	in	IN
cord-310192-8x37nx4s	217	41	Vallurupalli	Vallurupalli	NNP
cord-310192-8x37nx4s	217	42	et	et	NNP
cord-310192-8x37nx4s	217	43	al	al	NNP
cord-310192-8x37nx4s	217	44	.	.	NNP
cord-310192-8x37nx4s	217	45	,	,	,
cord-310192-8x37nx4s	217	46	2017	2017	CD
cord-310192-8x37nx4s	217	47	)	)	-RRB-
cord-310192-8x37nx4s	217	48	.	.	.
cord-310192-8x37nx4s	218	1	Recently	recently	RB
cord-310192-8x37nx4s	218	2	,	,	,
cord-310192-8x37nx4s	218	3	the	the	DT
cord-310192-8x37nx4s	218	4	Zhang	Zhang	NNP
cord-310192-8x37nx4s	218	5	lab	lab	NN
cord-310192-8x37nx4s	218	6	optimized	optimize	VBN
cord-310192-8x37nx4s	218	7	carbon	carbon	NN
cord-310192-8x37nx4s	218	8	CEST	CEST	NNP
cord-310192-8x37nx4s	218	9	experiments	experiment	NNS
cord-310192-8x37nx4s	218	10	for	for	IN
cord-310192-8x37nx4s	218	11	nucleic	nucleic	JJ
cord-310192-8x37nx4s	218	12	acids	acid	NNS
cord-310192-8x37nx4s	218	13	and	and	CC
cord-310192-8x37nx4s	218	14	applied	apply	VBD
cord-310192-8x37nx4s	218	15	these	these	DT
cord-310192-8x37nx4s	218	16	methods	method	NNS
cord-310192-8x37nx4s	218	17	as	as	RB
cord-310192-8x37nx4s	218	18	well	well	RB
cord-310192-8x37nx4s	218	19	as	as	IN
cord-310192-8x37nx4s	218	20	R1ρ	r1ρ	NN
cord-310192-8x37nx4s	218	21	experiments	experiment	NNS
cord-310192-8x37nx4s	218	22	(	(	-LRB-
cord-310192-8x37nx4s	218	23	see	see	VB
cord-310192-8x37nx4s	218	24	below	below	RB
cord-310192-8x37nx4s	218	25	)	)	-RRB-
cord-310192-8x37nx4s	218	26	to	to	IN
cord-310192-8x37nx4s	218	27	the	the	DT
cord-310192-8x37nx4s	218	28	study	study	NN
cord-310192-8x37nx4s	218	29	of	of	IN
cord-310192-8x37nx4s	218	30	a	a	DT
cord-310192-8x37nx4s	218	31	47	47	CD
cord-310192-8x37nx4s	218	32	nt	nt	RB
cord-310192-8x37nx4s	218	33	fluoride	fluoride	NN
cord-310192-8x37nx4s	218	34	riboswitch	riboswitch	NN
cord-310192-8x37nx4s	218	35	(	(	-LRB-
cord-310192-8x37nx4s	218	36	B.	B.	NNP
cord-310192-8x37nx4s	218	37	Zhao	Zhao	NNP
cord-310192-8x37nx4s	218	38	et	et	NNP
cord-310192-8x37nx4s	218	39	al	al	NNP
cord-310192-8x37nx4s	218	40	.	.	NNP
cord-310192-8x37nx4s	218	41	,	,	,
cord-310192-8x37nx4s	218	42	2014	2014	CD
cord-310192-8x37nx4s	218	43	)	)	-RRB-
cord-310192-8x37nx4s	218	44	.	.	.
cord-310192-8x37nx4s	219	1	In	in	IN
cord-310192-8x37nx4s	219	2	an	an	DT
cord-310192-8x37nx4s	219	3	effort	effort	NN
cord-310192-8x37nx4s	219	4	to	to	TO
cord-310192-8x37nx4s	219	5	fully	fully	RB
cord-310192-8x37nx4s	219	6	characterize	characterize	VB
cord-310192-8x37nx4s	219	7	riboswitch	riboswitch	NN
cord-310192-8x37nx4s	219	8	function	function	NN
cord-310192-8x37nx4s	219	9	,	,	,
cord-310192-8x37nx4s	219	10	structural	structural	JJ
cord-310192-8x37nx4s	219	11	insight	insight	NN
cord-310192-8x37nx4s	219	12	into	into	IN
cord-310192-8x37nx4s	219	13	the	the	DT
cord-310192-8x37nx4s	219	14	ligand	ligand	NN
cord-310192-8x37nx4s	219	15	free	free	JJ
cord-310192-8x37nx4s	219	16	state	state	NN
cord-310192-8x37nx4s	219	17	is	be	VBZ
cord-310192-8x37nx4s	219	18	essential	essential	JJ
cord-310192-8x37nx4s	219	19	.	.	.
cord-310192-8x37nx4s	220	1	Their	-PRON-	PRP$
cord-310192-8x37nx4s	220	2	work	work	NN
cord-310192-8x37nx4s	220	3	revealed	reveal	VBD
cord-310192-8x37nx4s	220	4	that	that	IN
cord-310192-8x37nx4s	220	5	the	the	DT
cord-310192-8x37nx4s	220	6	unliganded	unligande	VBN
cord-310192-8x37nx4s	220	7	riboswitch	riboswitch	NN
cord-310192-8x37nx4s	220	8	formed	form	VBD
cord-310192-8x37nx4s	220	9	a	a	DT
cord-310192-8x37nx4s	220	10	pseudoknot	pseudoknot	NN
cord-310192-8x37nx4s	220	11	-	-	HYPH
cord-310192-8x37nx4s	220	12	like	like	JJ
cord-310192-8x37nx4s	220	13	structure	structure	NN
cord-310192-8x37nx4s	220	14	that	that	WDT
cord-310192-8x37nx4s	220	15	is	be	VBZ
cord-310192-8x37nx4s	220	16	lowly	lowly	JJ
cord-310192-8x37nx4s	220	17	populated	populated	JJ
cord-310192-8x37nx4s	220	18	,	,	,
cord-310192-8x37nx4s	220	19	reminiscent	reminiscent	JJ
cord-310192-8x37nx4s	220	20	of	of	IN
cord-310192-8x37nx4s	220	21	the	the	DT
cord-310192-8x37nx4s	220	22	ligand	ligand	NN
cord-310192-8x37nx4s	220	23	-	-	HYPH
cord-310192-8x37nx4s	220	24	bound	bind	VBN
cord-310192-8x37nx4s	220	25	structure	structure	NN
cord-310192-8x37nx4s	220	26	,	,	,
cord-310192-8x37nx4s	220	27	and	and	CC
cord-310192-8x37nx4s	220	28	was	be	VBD
cord-310192-8x37nx4s	220	29	undetectable	undetectable	JJ
cord-310192-8x37nx4s	220	30	via	via	IN
cord-310192-8x37nx4s	220	31	conventional	conventional	JJ
cord-310192-8x37nx4s	220	32	approaches	approach	NNS
cord-310192-8x37nx4s	220	33	(	(	-LRB-
cord-310192-8x37nx4s	220	34	B.	B.	NNP
cord-310192-8x37nx4s	220	35	Zhao	Zhao	NNP
cord-310192-8x37nx4s	220	36	et	et	NNP
cord-310192-8x37nx4s	220	37	al	al	NNP
cord-310192-8x37nx4s	220	38	.	.	NNP
cord-310192-8x37nx4s	220	39	,	,	,
cord-310192-8x37nx4s	220	40	2014	2014	CD
cord-310192-8x37nx4s	220	41	)	)	-RRB-
cord-310192-8x37nx4s	220	42	.	.	.
cord-310192-8x37nx4s	221	1	CEST	CEST	NNP
cord-310192-8x37nx4s	221	2	experiments	experiment	NNS
cord-310192-8x37nx4s	221	3	do	do	VBP
cord-310192-8x37nx4s	221	4	not	not	RB
cord-310192-8x37nx4s	221	5	require	require	VB
cord-310192-8x37nx4s	221	6	specialized	specialized	JJ
cord-310192-8x37nx4s	221	7	isotopic	isotopic	JJ
cord-310192-8x37nx4s	221	8	labeling	labeling	NN
cord-310192-8x37nx4s	221	9	strategies	strategy	NNS
cord-310192-8x37nx4s	221	10	and	and	CC
cord-310192-8x37nx4s	221	11	can	can	MD
cord-310192-8x37nx4s	221	12	be	be	VB
cord-310192-8x37nx4s	221	13	conducted	conduct	VBN
cord-310192-8x37nx4s	221	14	on	on	IN
cord-310192-8x37nx4s	221	15	RNAs	rna	NNS
cord-310192-8x37nx4s	221	16	that	that	WDT
cord-310192-8x37nx4s	221	17	are	be	VBP
cord-310192-8x37nx4s	221	18	uniformly	uniformly	RB
cord-310192-8x37nx4s	221	19	15	15	CD
cord-310192-8x37nx4s	221	20	N/	N/	NNP
cord-310192-8x37nx4s	221	21	13	13	CD
cord-310192-8x37nx4s	221	22	C	c	NN
cord-310192-8x37nx4s	221	23	labeled	label	VBN
cord-310192-8x37nx4s	221	24	.	.	.
cord-310192-8x37nx4s	222	1	Relaxation	relaxation	NN
cord-310192-8x37nx4s	222	2	dispersion	dispersion	NN
cord-310192-8x37nx4s	222	3	(	(	-LRB-
cord-310192-8x37nx4s	222	4	RD	RD	NNP
cord-310192-8x37nx4s	222	5	)	)	-RRB-
cord-310192-8x37nx4s	222	6	NMR	NMR	NNP
cord-310192-8x37nx4s	222	7	experiments	experiment	NNS
cord-310192-8x37nx4s	222	8	are	be	VBP
cord-310192-8x37nx4s	222	9	frequently	frequently	RB
cord-310192-8x37nx4s	222	10	used	use	VBN
cord-310192-8x37nx4s	222	11	to	to	TO
cord-310192-8x37nx4s	222	12	characterize	characterize	VB
cord-310192-8x37nx4s	222	13	excited	excited	JJ
cord-310192-8x37nx4s	222	14	states	state	NNS
cord-310192-8x37nx4s	222	15	(	(	-LRB-
cord-310192-8x37nx4s	222	16	ESs	ESs	NNP
cord-310192-8x37nx4s	222	17	)	)	-RRB-
cord-310192-8x37nx4s	222	18	of	of	IN
cord-310192-8x37nx4s	222	19	biomolecules	biomolecule	NNS
cord-310192-8x37nx4s	222	20	(	(	-LRB-
cord-310192-8x37nx4s	222	21	reviewed	review	VBN
cord-310192-8x37nx4s	222	22	in	in	IN
cord-310192-8x37nx4s	222	23	Al	Al	NNP
cord-310192-8x37nx4s	222	24	-	-	HYPH
cord-310192-8x37nx4s	222	25	Hashimi	Hashimi	NNP
cord-310192-8x37nx4s	222	26	,	,	,
cord-310192-8x37nx4s	222	27	2013	2013	CD
cord-310192-8x37nx4s	222	28	;	;	:
cord-310192-8x37nx4s	222	29	Bothe	Bothe	NNP
cord-310192-8x37nx4s	222	30	et	et	FW
cord-310192-8x37nx4s	222	31	al	al	NNP
cord-310192-8x37nx4s	222	32	.	.	NNP
cord-310192-8x37nx4s	222	33	,	,	,
cord-310192-8x37nx4s	222	34	2011	2011	CD
cord-310192-8x37nx4s	222	35	;	;	:
cord-310192-8x37nx4s	222	36	Xue	Xue	NNP
cord-310192-8x37nx4s	222	37	et	et	NNP
cord-310192-8x37nx4s	222	38	al	al	NNP
cord-310192-8x37nx4s	222	39	.	.	NNP
cord-310192-8x37nx4s	222	40	,	,	,
cord-310192-8x37nx4s	222	41	2015	2015	CD
cord-310192-8x37nx4s	222	42	)	)	-RRB-
cord-310192-8x37nx4s	222	43	.	.	.
cord-310192-8x37nx4s	223	1	One	one	CD
cord-310192-8x37nx4s	223	2	such	such	JJ
cord-310192-8x37nx4s	223	3	RD	RD	NNP
cord-310192-8x37nx4s	223	4	experiment	experiment	NN
cord-310192-8x37nx4s	223	5	is	be	VBZ
cord-310192-8x37nx4s	223	6	the	the	DT
cord-310192-8x37nx4s	223	7	R1ρ	R1ρ	NNP
cord-310192-8x37nx4s	223	8	experiment	experiment	NN
cord-310192-8x37nx4s	223	9	(	(	-LRB-
cord-310192-8x37nx4s	223	10	reviewed	review	VBN
cord-310192-8x37nx4s	223	11	in	in	IN
cord-310192-8x37nx4s	223	12	Bothe	Bothe	NNP
cord-310192-8x37nx4s	223	13	et	et	FW
cord-310192-8x37nx4s	223	14	al	al	NNP
cord-310192-8x37nx4s	223	15	.	.	NNP
cord-310192-8x37nx4s	223	16	,	,	,
cord-310192-8x37nx4s	223	17	2011	2011	CD
cord-310192-8x37nx4s	223	18	;	;	:
cord-310192-8x37nx4s	223	19	Palmer	Palmer	NNP
cord-310192-8x37nx4s	223	20	&	&	CC
cord-310192-8x37nx4s	223	21	Massi	Massi	NNP
cord-310192-8x37nx4s	223	22	,	,	,
cord-310192-8x37nx4s	223	23	2006	2006	CD
cord-310192-8x37nx4s	223	24	)	)	-RRB-
cord-310192-8x37nx4s	223	25	.	.	.
cord-310192-8x37nx4s	224	1	R1ρ	r1ρ	NN
cord-310192-8x37nx4s	224	2	experiments	experiment	NNS
cord-310192-8x37nx4s	224	3	can	can	MD
cord-310192-8x37nx4s	224	4	provide	provide	VB
cord-310192-8x37nx4s	224	5	structural	structural	JJ
cord-310192-8x37nx4s	224	6	and	and	CC
cord-310192-8x37nx4s	224	7	functional	functional	JJ
cord-310192-8x37nx4s	224	8	insight	insight	NN
cord-310192-8x37nx4s	224	9	for	for	IN
cord-310192-8x37nx4s	224	10	low	low	RB
cord-310192-8x37nx4s	224	11	-	-	HYPH
cord-310192-8x37nx4s	224	12	populated	populated	JJ
cord-310192-8x37nx4s	224	13	ESs	es	NNS
cord-310192-8x37nx4s	224	14	that	that	WDT
cord-310192-8x37nx4s	224	15	have	have	VBP
cord-310192-8x37nx4s	224	16	short	short	JJ
cord-310192-8x37nx4s	224	17	lifetimes	lifetime	NNS
cord-310192-8x37nx4s	224	18	.	.	.
cord-310192-8x37nx4s	225	1	This	this	DT
cord-310192-8x37nx4s	225	2	approach	approach	NN
cord-310192-8x37nx4s	225	3	was	be	VBD
cord-310192-8x37nx4s	225	4	used	use	VBN
cord-310192-8x37nx4s	225	5	to	to	TO
cord-310192-8x37nx4s	225	6	characterize	characterize	VB
cord-310192-8x37nx4s	225	7	the	the	DT
cord-310192-8x37nx4s	225	8	dynamics	dynamic	NNS
cord-310192-8x37nx4s	225	9	of	of	IN
cord-310192-8x37nx4s	225	10	a	a	DT
cord-310192-8x37nx4s	225	11	31	31	CD
cord-310192-8x37nx4s	225	12	nt	nt	NN
cord-310192-8x37nx4s	225	13	portion	portion	NN
cord-310192-8x37nx4s	225	14	of	of	IN
cord-310192-8x37nx4s	225	15	ribosomal	ribosomal	NNP
cord-310192-8x37nx4s	225	16	RNA	RNA	NNP
cord-310192-8x37nx4s	225	17	,	,	,
cord-310192-8x37nx4s	225	18	the	the	DT
cord-310192-8x37nx4s	225	19	A	A	NNP
cord-310192-8x37nx4s	225	20	-	-	HYPH
cord-310192-8x37nx4s	225	21	site	site	NN
cord-310192-8x37nx4s	225	22	,	,	,
cord-310192-8x37nx4s	225	23	which	which	WDT
cord-310192-8x37nx4s	225	24	must	must	MD
cord-310192-8x37nx4s	225	25	dynamically	dynamically	RB
cord-310192-8x37nx4s	225	26	sample	sample	VB
cord-310192-8x37nx4s	225	27	multiple	multiple	JJ
cord-310192-8x37nx4s	225	28	conformations	conformation	NNS
cord-310192-8x37nx4s	225	29	to	to	TO
cord-310192-8x37nx4s	225	30	decode	decode	VB
cord-310192-8x37nx4s	225	31	a	a	DT
cord-310192-8x37nx4s	225	32	messenger	messenger	NN
cord-310192-8x37nx4s	225	33	RNA	RNA	NNP
cord-310192-8x37nx4s	225	34	(	(	-LRB-
cord-310192-8x37nx4s	225	35	Dethoff	Dethoff	NNP
cord-310192-8x37nx4s	225	36	,	,	,
cord-310192-8x37nx4s	225	37	Petzold	Petzold	NNP
cord-310192-8x37nx4s	225	38	,	,	,
cord-310192-8x37nx4s	225	39	Chugh	Chugh	NNP
cord-310192-8x37nx4s	225	40	,	,	,
cord-310192-8x37nx4s	225	41	Casiano	Casiano	NNP
cord-310192-8x37nx4s	225	42	-	-	HYPH
cord-310192-8x37nx4s	225	43	Negroni	Negroni	NNP
cord-310192-8x37nx4s	225	44	,	,	,
cord-310192-8x37nx4s	225	45	&	&	CC
cord-310192-8x37nx4s	225	46	Al	Al	NNP
cord-310192-8x37nx4s	225	47	-	-	HYPH
cord-310192-8x37nx4s	225	48	Hashimi	Hashimi	NNP
cord-310192-8x37nx4s	225	49	,	,	,
cord-310192-8x37nx4s	225	50	2012	2012	CD
cord-310192-8x37nx4s	225	51	;	;	:
cord-310192-8x37nx4s	225	52	A.	A.	NNP
cord-310192-8x37nx4s	225	53	L.	L.	NNP
cord-310192-8x37nx4s	225	54	Hansen	Hansen	NNP
cord-310192-8x37nx4s	225	55	,	,	,
cord-310192-8x37nx4s	225	56	Nikolova	Nikolova	NNP
cord-310192-8x37nx4s	225	57	,	,	,
cord-310192-8x37nx4s	225	58	Casiano	Casiano	NNP
cord-310192-8x37nx4s	225	59	-	-	HYPH
cord-310192-8x37nx4s	225	60	Negroni	Negroni	NNP
cord-310192-8x37nx4s	225	61	,	,	,
cord-310192-8x37nx4s	225	62	&	&	CC
cord-310192-8x37nx4s	225	63	Al	Al	NNP
cord-310192-8x37nx4s	225	64	-	-	HYPH
cord-310192-8x37nx4s	225	65	Hashimi	Hashimi	NNP
cord-310192-8x37nx4s	225	66	,	,	,
cord-310192-8x37nx4s	225	67	2009	2009	CD
cord-310192-8x37nx4s	225	68	)	)	-RRB-
cord-310192-8x37nx4s	225	69	.	.	.
cord-310192-8x37nx4s	226	1	R1ρ	r1ρ	NN
cord-310192-8x37nx4s	226	2	experiments	experiment	NNS
cord-310192-8x37nx4s	226	3	have	have	VBP
cord-310192-8x37nx4s	226	4	also	also	RB
cord-310192-8x37nx4s	226	5	provided	provide	VBN
cord-310192-8x37nx4s	226	6	insight	insight	NN
cord-310192-8x37nx4s	226	7	into	into	IN
cord-310192-8x37nx4s	226	8	the	the	DT
cord-310192-8x37nx4s	226	9	roles	role	NNS
cord-310192-8x37nx4s	226	10	of	of	IN
cord-310192-8x37nx4s	226	11	structured	structured	JJ
cord-310192-8x37nx4s	226	12	RNA	RNA	NNP
cord-310192-8x37nx4s	226	13	elements	element	NNS
cord-310192-8x37nx4s	226	14	within	within	IN
cord-310192-8x37nx4s	226	15	the	the	DT
cord-310192-8x37nx4s	226	16	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	226	17	genome	genome	NN
cord-310192-8x37nx4s	226	18	,	,	,
cord-310192-8x37nx4s	226	19	including	include	VBG
cord-310192-8x37nx4s	226	20	the	the	DT
cord-310192-8x37nx4s	226	21	transactivation	transactivation	NN
cord-310192-8x37nx4s	226	22	response	response	NN
cord-310192-8x37nx4s	226	23	(	(	-LRB-
cord-310192-8x37nx4s	226	24	TAR	tar	NN
cord-310192-8x37nx4s	226	25	)	)	-RRB-
cord-310192-8x37nx4s	226	26	element	element	NN
cord-310192-8x37nx4s	226	27	apical	apical	JJ
cord-310192-8x37nx4s	226	28	loop	loop	NN
cord-310192-8x37nx4s	226	29	and	and	CC
cord-310192-8x37nx4s	226	30	the	the	DT
cord-310192-8x37nx4s	226	31	primary	primary	JJ
cord-310192-8x37nx4s	226	32	dimer	dimer	NN
cord-310192-8x37nx4s	226	33	initiation	initiation	NN
cord-310192-8x37nx4s	226	34	site	site	NN
cord-310192-8x37nx4s	226	35	(	(	-LRB-
cord-310192-8x37nx4s	226	36	SL1	SL1	NNP
cord-310192-8x37nx4s	226	37	)	)	-RRB-
cord-310192-8x37nx4s	226	38	(	(	-LRB-
cord-310192-8x37nx4s	226	39	Dethoff	Dethoff	NNP
cord-310192-8x37nx4s	226	40	,	,	,
cord-310192-8x37nx4s	226	41	Petzold	Petzold	NNP
cord-310192-8x37nx4s	226	42	,	,	,
cord-310192-8x37nx4s	226	43	et	et	NNP
cord-310192-8x37nx4s	226	44	al	al	NNP
cord-310192-8x37nx4s	226	45	.	.	NNP
cord-310192-8x37nx4s	226	46	,	,	,
cord-310192-8x37nx4s	226	47	2012	2012	CD
cord-310192-8x37nx4s	226	48	)	)	-RRB-
cord-310192-8x37nx4s	226	49	.	.	.
cord-310192-8x37nx4s	227	1	The	the	DT
cord-310192-8x37nx4s	227	2	Al	Al	NNP
cord-310192-8x37nx4s	227	3	-	-	HYPH
cord-310192-8x37nx4s	227	4	Hashimi	Hashimi	NNP
cord-310192-8x37nx4s	227	5	lab	lab	NN
cord-310192-8x37nx4s	227	6	characterized	characterize	VBD
cord-310192-8x37nx4s	227	7	the	the	DT
cord-310192-8x37nx4s	227	8	ES	es	NN
cord-310192-8x37nx4s	227	9	of	of	IN
cord-310192-8x37nx4s	227	10	the	the	DT
cord-310192-8x37nx4s	227	11	14	14	CD
cord-310192-8x37nx4s	227	12	nt	nt	NNP
cord-310192-8x37nx4s	227	13	TAR	TAR	NNP
cord-310192-8x37nx4s	227	14	RNA	RNA	NNP
cord-310192-8x37nx4s	227	15	apical	apical	JJ
cord-310192-8x37nx4s	227	16	loop	loop	NN
cord-310192-8x37nx4s	227	17	,	,	,
cord-310192-8x37nx4s	227	18	in	in	IN
cord-310192-8x37nx4s	227	19	which	which	WDT
cord-310192-8x37nx4s	227	20	many	many	JJ
cord-310192-8x37nx4s	227	21	of	of	IN
cord-310192-8x37nx4s	227	22	the	the	DT
cord-310192-8x37nx4s	227	23	loop	loop	NN
cord-310192-8x37nx4s	227	24	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	227	25	are	be	VBP
cord-310192-8x37nx4s	227	26	sequestered	sequester	VBN
cord-310192-8x37nx4s	227	27	in	in	IN
cord-310192-8x37nx4s	227	28	base	base	NN
cord-310192-8x37nx4s	227	29	pairing	pairing	NN
cord-310192-8x37nx4s	227	30	(	(	-LRB-
cord-310192-8x37nx4s	227	31	Dethoff	Dethoff	NNP
cord-310192-8x37nx4s	227	32	,	,	,
cord-310192-8x37nx4s	227	33	Petzold	Petzold	NNP
cord-310192-8x37nx4s	227	34	,	,	,
cord-310192-8x37nx4s	227	35	et	et	NNP
cord-310192-8x37nx4s	227	36	al	al	NNP
cord-310192-8x37nx4s	227	37	.	.	NNP
cord-310192-8x37nx4s	227	38	,	,	,
cord-310192-8x37nx4s	227	39	2012	2012	CD
cord-310192-8x37nx4s	227	40	)	)	-RRB-
cord-310192-8x37nx4s	227	41	.	.	.
cord-310192-8x37nx4s	228	1	The	the	DT
cord-310192-8x37nx4s	228	2	sequestration	sequestration	NN
cord-310192-8x37nx4s	228	3	of	of	IN
cord-310192-8x37nx4s	228	4	loop	loop	NN
cord-310192-8x37nx4s	228	5	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	228	6	in	in	IN
cord-310192-8x37nx4s	228	7	the	the	DT
cord-310192-8x37nx4s	228	8	TAR	tar	NN
cord-310192-8x37nx4s	228	9	ES	ES	NNP
cord-310192-8x37nx4s	228	10	inhibits	inhibit	VBZ
cord-310192-8x37nx4s	228	11	binding	bind	VBG
cord-310192-8x37nx4s	228	12	by	by	IN
cord-310192-8x37nx4s	228	13	the	the	DT
cord-310192-8x37nx4s	228	14	viral	viral	JJ
cord-310192-8x37nx4s	228	15	transactivator	transactivator	NN
cord-310192-8x37nx4s	228	16	protein	protein	NN
cord-310192-8x37nx4s	228	17	and	and	CC
cord-310192-8x37nx4s	228	18	human	human	JJ
cord-310192-8x37nx4s	228	19	cyclin	cyclin	NN
cord-310192-8x37nx4s	228	20	T1	T1	NNP
cord-310192-8x37nx4s	228	21	,	,	,
cord-310192-8x37nx4s	228	22	activating	activate	VBG
cord-310192-8x37nx4s	228	23	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	228	24	genome	genome	NN
cord-310192-8x37nx4s	228	25	transcription	transcription	NN
cord-310192-8x37nx4s	228	26	(	(	-LRB-
cord-310192-8x37nx4s	228	27	Dethoff	Dethoff	NNP
cord-310192-8x37nx4s	228	28	,	,	,
cord-310192-8x37nx4s	228	29	Petzold	Petzold	NNP
cord-310192-8x37nx4s	228	30	,	,	,
cord-310192-8x37nx4s	228	31	et	et	NNP
cord-310192-8x37nx4s	228	32	al	al	NNP
cord-310192-8x37nx4s	228	33	.	.	NNP
cord-310192-8x37nx4s	228	34	,	,	,
cord-310192-8x37nx4s	228	35	2012	2012	CD
cord-310192-8x37nx4s	228	36	)	)	-RRB-
cord-310192-8x37nx4s	228	37	.	.	.
cord-310192-8x37nx4s	229	1	The	the	DT
cord-310192-8x37nx4s	229	2	36	36	CD
cord-310192-8x37nx4s	229	3	nt	nt	NN
cord-310192-8x37nx4s	229	4	SL1	SL1	NNP
cord-310192-8x37nx4s	229	5	exhibited	exhibit	VBD
cord-310192-8x37nx4s	229	6	significant	significant	JJ
cord-310192-8x37nx4s	229	7	conformational	conformational	JJ
cord-310192-8x37nx4s	229	8	exchange	exchange	NN
cord-310192-8x37nx4s	229	9	,	,	,
cord-310192-8x37nx4s	229	10	consistent	consistent	JJ
cord-310192-8x37nx4s	229	11	with	with	IN
cord-310192-8x37nx4s	229	12	not	not	RB
cord-310192-8x37nx4s	229	13	one	one	CD
cord-310192-8x37nx4s	229	14	,	,	,
cord-310192-8x37nx4s	229	15	but	but	CC
cord-310192-8x37nx4s	229	16	two	two	CD
cord-310192-8x37nx4s	229	17	excited	excited	JJ
cord-310192-8x37nx4s	229	18	state	state	NN
cord-310192-8x37nx4s	229	19	structures	structure	NNS
cord-310192-8x37nx4s	229	20	and	and	CC
cord-310192-8x37nx4s	229	21	the	the	DT
cord-310192-8x37nx4s	229	22	authors	author	NNS
cord-310192-8x37nx4s	229	23	propose	propose	VBP
cord-310192-8x37nx4s	229	24	that	that	IN
cord-310192-8x37nx4s	229	25	these	these	DT
cord-310192-8x37nx4s	229	26	ESs	es	NNS
cord-310192-8x37nx4s	229	27	play	play	VBP
cord-310192-8x37nx4s	229	28	important	important	JJ
cord-310192-8x37nx4s	229	29	roles	role	NNS
cord-310192-8x37nx4s	229	30	in	in	IN
cord-310192-8x37nx4s	229	31	intermolecular	intermolecular	JJ
cord-310192-8x37nx4s	229	32	dimerization	dimerization	NN
cord-310192-8x37nx4s	229	33	(	(	-LRB-
cord-310192-8x37nx4s	229	34	Dethoff	Dethoff	NNP
cord-310192-8x37nx4s	229	35	,	,	,
cord-310192-8x37nx4s	229	36	Petzold	Petzold	NNP
cord-310192-8x37nx4s	229	37	,	,	,
cord-310192-8x37nx4s	229	38	et	et	NNP
cord-310192-8x37nx4s	229	39	al	al	NNP
cord-310192-8x37nx4s	229	40	.	.	NNP
cord-310192-8x37nx4s	229	41	,	,	,
cord-310192-8x37nx4s	229	42	2012	2012	CD
cord-310192-8x37nx4s	229	43	)	)	-RRB-
cord-310192-8x37nx4s	229	44	.	.	.
cord-310192-8x37nx4s	230	1	Similar	similar	JJ
cord-310192-8x37nx4s	230	2	to	to	IN
cord-310192-8x37nx4s	230	3	CEST	CEST	NNP
cord-310192-8x37nx4s	230	4	experiments	experiment	NNS
cord-310192-8x37nx4s	230	5	,	,	,
cord-310192-8x37nx4s	230	6	R1ρ	r1ρ	NN
cord-310192-8x37nx4s	230	7	experiments	experiment	NNS
cord-310192-8x37nx4s	230	8	can	can	MD
cord-310192-8x37nx4s	230	9	be	be	VB
cord-310192-8x37nx4s	230	10	carried	carry	VBN
cord-310192-8x37nx4s	230	11	out	out	RP
cord-310192-8x37nx4s	230	12	using	use	VBG
cord-310192-8x37nx4s	230	13	uniformly	uniformly	RB
cord-310192-8x37nx4s	230	14	15	15	CD
cord-310192-8x37nx4s	230	15	N/	N/	NNP
cord-310192-8x37nx4s	230	16	13	13	CD
cord-310192-8x37nx4s	230	17	C	c	NN
cord-310192-8x37nx4s	230	18	-	-	HYPH
cord-310192-8x37nx4s	230	19	labeled	label	VBN
cord-310192-8x37nx4s	230	20	or	or	CC
cord-310192-8x37nx4s	230	21	unlabeled	unlabeled	JJ
cord-310192-8x37nx4s	230	22	(	(	-LRB-
cord-310192-8x37nx4s	230	23	A.	A.	NNP
cord-310192-8x37nx4s	230	24	L.	L.	NNP
cord-310192-8x37nx4s	230	25	Hansen	Hansen	NNP
cord-310192-8x37nx4s	230	26	et	et	NNP
cord-310192-8x37nx4s	230	27	al	al	NNP
cord-310192-8x37nx4s	230	28	.	.	NNP
cord-310192-8x37nx4s	230	29	,	,	,
cord-310192-8x37nx4s	230	30	2009	2009	CD
cord-310192-8x37nx4s	230	31	)	)	-RRB-
cord-310192-8x37nx4s	230	32	RNAs	rna	NNS
cord-310192-8x37nx4s	230	33	but	but	CC
cord-310192-8x37nx4s	230	34	have	have	VBP
cord-310192-8x37nx4s	230	35	thus	thus	RB
cord-310192-8x37nx4s	230	36	far	far	RB
cord-310192-8x37nx4s	230	37	been	be	VBN
cord-310192-8x37nx4s	230	38	applied	apply	VBN
cord-310192-8x37nx4s	230	39	to	to	IN
cord-310192-8x37nx4s	230	40	the	the	DT
cord-310192-8x37nx4s	230	41	study	study	NN
cord-310192-8x37nx4s	230	42	of	of	IN
cord-310192-8x37nx4s	230	43	relatively	relatively	RB
cord-310192-8x37nx4s	230	44	small	small	JJ
cord-310192-8x37nx4s	230	45	RNAs	rna	NNS
cord-310192-8x37nx4s	230	46	.	.	.
cord-310192-8x37nx4s	231	1	Another	another	DT
cord-310192-8x37nx4s	231	2	common	common	JJ
cord-310192-8x37nx4s	231	3	RD	RD	NNP
cord-310192-8x37nx4s	231	4	-	-	HYPH
cord-310192-8x37nx4s	231	5	based	base	VBN
cord-310192-8x37nx4s	231	6	experiment	experiment	NN
cord-310192-8x37nx4s	231	7	used	use	VBN
cord-310192-8x37nx4s	231	8	to	to	TO
cord-310192-8x37nx4s	231	9	characterize	characterize	VB
cord-310192-8x37nx4s	231	10	protein	protein	NN
cord-310192-8x37nx4s	231	11	and	and	CC
cord-310192-8x37nx4s	231	12	nucleic	nucleic	JJ
cord-310192-8x37nx4s	231	13	acid	acid	NN
cord-310192-8x37nx4s	231	14	dynamics	dynamic	NNS
cord-310192-8x37nx4s	231	15	in	in	IN
cord-310192-8x37nx4s	231	16	the	the	DT
cord-310192-8x37nx4s	231	17	microsecond	microsecond	JJ
cord-310192-8x37nx4s	231	18	-	-	HYPH
cord-310192-8x37nx4s	231	19	tomillisecond	tomillisecond	NN
cord-310192-8x37nx4s	231	20	timescale	timescale	NN
cord-310192-8x37nx4s	231	21	is	be	VBZ
cord-310192-8x37nx4s	231	22	the	the	DT
cord-310192-8x37nx4s	231	23	Carr	Carr	NNP
cord-310192-8x37nx4s	231	24	-	-	HYPH
cord-310192-8x37nx4s	231	25	Purcell	Purcell	NNP
cord-310192-8x37nx4s	231	26	-	-	HYPH
cord-310192-8x37nx4s	231	27	Meiboom	Meiboom	NNP
cord-310192-8x37nx4s	231	28	-	-	HYPH
cord-310192-8x37nx4s	231	29	Gill	Gill	NNP
cord-310192-8x37nx4s	231	30	(	(	-LRB-
cord-310192-8x37nx4s	231	31	CPMG	CPMG	NNP
cord-310192-8x37nx4s	231	32	)	)	-RRB-
cord-310192-8x37nx4s	231	33	experiment	experiment	NN
cord-310192-8x37nx4s	231	34	(	(	-LRB-
cord-310192-8x37nx4s	231	35	Yamazaki	Yamazaki	NNP
cord-310192-8x37nx4s	231	36	,	,	,
cord-310192-8x37nx4s	231	37	Muhandiram	Muhandiram	NNP
cord-310192-8x37nx4s	231	38	,	,	,
cord-310192-8x37nx4s	231	39	&	&	CC
cord-310192-8x37nx4s	231	40	Kay	Kay	NNP
cord-310192-8x37nx4s	231	41	,	,	,
cord-310192-8x37nx4s	231	42	1994	1994	CD
cord-310192-8x37nx4s	231	43	)	)	-RRB-
cord-310192-8x37nx4s	231	44	.	.	.
cord-310192-8x37nx4s	232	1	CPMG	CPMG	NNP
cord-310192-8x37nx4s	232	2	can	can	MD
cord-310192-8x37nx4s	232	3	help	help	VB
cord-310192-8x37nx4s	232	4	extract	extract	VB
cord-310192-8x37nx4s	232	5	parameters	parameter	NNS
cord-310192-8x37nx4s	232	6	like	like	IN
cord-310192-8x37nx4s	232	7	population	population	NN
cord-310192-8x37nx4s	232	8	,	,	,
cord-310192-8x37nx4s	232	9	life	life	NN
cord-310192-8x37nx4s	232	10	time	time	NN
cord-310192-8x37nx4s	232	11	and	and	CC
cord-310192-8x37nx4s	232	12	chemical	chemical	NN
cord-310192-8x37nx4s	232	13	shifts	shift	NNS
cord-310192-8x37nx4s	232	14	of	of	IN
cord-310192-8x37nx4s	232	15	ES	ES	NNP
cord-310192-8x37nx4s	232	16	in	in	IN
cord-310192-8x37nx4s	232	17	slow	slow	JJ
cord-310192-8x37nx4s	232	18	and	and	CC
cord-310192-8x37nx4s	232	19	intermediate	intermediate	JJ
cord-310192-8x37nx4s	232	20	exchange	exchange	NN
cord-310192-8x37nx4s	232	21	.	.	.
cord-310192-8x37nx4s	233	1	Extensive	extensive	JJ
cord-310192-8x37nx4s	233	2	studies	study	NNS
cord-310192-8x37nx4s	233	3	have	have	VBP
cord-310192-8x37nx4s	233	4	been	be	VBN
cord-310192-8x37nx4s	233	5	conducted	conduct	VBN
cord-310192-8x37nx4s	233	6	in	in	IN
cord-310192-8x37nx4s	233	7	protein	protein	NN
cord-310192-8x37nx4s	233	8	dynamics	dynamic	NNS
cord-310192-8x37nx4s	233	9	by	by	IN
cord-310192-8x37nx4s	233	10	CPMG	CPMG	NNP
cord-310192-8x37nx4s	233	11	,	,	,
cord-310192-8x37nx4s	233	12	but	but	CC
cord-310192-8x37nx4s	233	13	in	in	IN
cord-310192-8x37nx4s	233	14	nucleic	nucleic	JJ
cord-310192-8x37nx4s	233	15	acids	acid	NNS
cord-310192-8x37nx4s	233	16	CPMG	CPMG	NNP
cord-310192-8x37nx4s	233	17	study	study	NN
cord-310192-8x37nx4s	233	18	is	be	VBZ
cord-310192-8x37nx4s	233	19	highly	highly	RB
cord-310192-8x37nx4s	233	20	limited	limited	JJ
cord-310192-8x37nx4s	233	21	due	due	IN
cord-310192-8x37nx4s	233	22	to	to	IN
cord-310192-8x37nx4s	233	23	the	the	DT
cord-310192-8x37nx4s	233	24	intrinsic	intrinsic	JJ
cord-310192-8x37nx4s	233	25	characteristics	characteristic	NNS
cord-310192-8x37nx4s	233	26	of	of	IN
cord-310192-8x37nx4s	233	27	DNA	DNA	NNP
cord-310192-8x37nx4s	233	28	and	and	CC
cord-310192-8x37nx4s	233	29	RNA	RNA	NNP
cord-310192-8x37nx4s	233	30	molecules	molecule	NNS
cord-310192-8x37nx4s	233	31	,	,	,
cord-310192-8x37nx4s	233	32	such	such	JJ
cord-310192-8x37nx4s	233	33	as	as	IN
cord-310192-8x37nx4s	233	34	13	13	CD
cord-310192-8x37nx4s	233	35	C-13	C-13	NNP
cord-310192-8x37nx4s	233	36	C	C	NNP
cord-310192-8x37nx4s	233	37	J	J	NNP
cord-310192-8x37nx4s	233	38	coupling	coupling	NN
cord-310192-8x37nx4s	233	39	and	and	CC
cord-310192-8x37nx4s	233	40	signal	signal	NN
cord-310192-8x37nx4s	233	41	degeneracy	degeneracy	NN
cord-310192-8x37nx4s	233	42	(	(	-LRB-
cord-310192-8x37nx4s	233	43	Johnson	Johnson	NNP
cord-310192-8x37nx4s	233	44	&	&	CC
cord-310192-8x37nx4s	233	45	Hoogstraten	Hoogstraten	NNP
cord-310192-8x37nx4s	233	46	,	,	,
cord-310192-8x37nx4s	233	47	2008	2008	CD
cord-310192-8x37nx4s	233	48	;	;	:
cord-310192-8x37nx4s	233	49	Lundstrom	Lundstrom	NNP
cord-310192-8x37nx4s	233	50	,	,	,
cord-310192-8x37nx4s	233	51	Hansen	Hansen	NNP
cord-310192-8x37nx4s	233	52	,	,	,
cord-310192-8x37nx4s	233	53	&	&	CC
cord-310192-8x37nx4s	233	54	Kay	Kay	NNP
cord-310192-8x37nx4s	233	55	,	,	,
cord-310192-8x37nx4s	233	56	2008	2008	CD
cord-310192-8x37nx4s	233	57	)	)	-RRB-
cord-310192-8x37nx4s	233	58	.	.	.
cord-310192-8x37nx4s	234	1	Recently	recently	RB
cord-310192-8x37nx4s	234	2	,	,	,
cord-310192-8x37nx4s	234	3	using	use	VBG
cord-310192-8x37nx4s	234	4	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	234	5	that	that	WDT
cord-310192-8x37nx4s	234	6	are	be	VBP
cord-310192-8x37nx4s	234	7	selectively	selectively	RB
cord-310192-8x37nx4s	234	8	labeled	label	VBN
cord-310192-8x37nx4s	234	9	with	with	IN
cord-310192-8x37nx4s	234	10	13	13	CD
cord-310192-8x37nx4s	234	11	C	C	NNP
cord-310192-8x37nx4s	234	12	and/or	and/or	CC
cord-310192-8x37nx4s	234	13	15	15	CD
cord-310192-8x37nx4s	234	14	N	n	CD
cord-310192-8x37nx4s	234	15	at	at	IN
cord-310192-8x37nx4s	234	16	specific	specific	JJ
cord-310192-8x37nx4s	234	17	atom	atom	NN
cord-310192-8x37nx4s	234	18	positions	position	NNS
cord-310192-8x37nx4s	234	19	(	(	-LRB-
cord-310192-8x37nx4s	234	20	as	as	IN
cord-310192-8x37nx4s	234	21	described	describe	VBN
cord-310192-8x37nx4s	234	22	above	above	IN
cord-310192-8x37nx4s	234	23	)	)	-RRB-
cord-310192-8x37nx4s	234	24	,	,	,
cord-310192-8x37nx4s	234	25	CPMG	CPMG	NNP
cord-310192-8x37nx4s	234	26	was	be	VBD
cord-310192-8x37nx4s	234	27	used	use	VBN
cord-310192-8x37nx4s	234	28	to	to	TO
cord-310192-8x37nx4s	234	29	study	study	VB
cord-310192-8x37nx4s	234	30	the	the	DT
cord-310192-8x37nx4s	234	31	dynamics	dynamic	NNS
cord-310192-8x37nx4s	234	32	of	of	IN
cord-310192-8x37nx4s	234	33	relatively	relatively	RB
cord-310192-8x37nx4s	234	34	large	large	JJ
cord-310192-8x37nx4s	234	35	RNAs	rna	NNS
cord-310192-8x37nx4s	234	36	including	include	VBG
cord-310192-8x37nx4s	234	37	the	the	DT
cord-310192-8x37nx4s	234	38	59	59	CD
cord-310192-8x37nx4s	234	39	nt	nt	RB
cord-310192-8x37nx4s	234	40	frame	frame	NN
cord-310192-8x37nx4s	234	41	-	-	HYPH
cord-310192-8x37nx4s	234	42	shifting	shift	VBG
cord-310192-8x37nx4s	234	43	element	element	NN
cord-310192-8x37nx4s	234	44	from	from	IN
cord-310192-8x37nx4s	234	45	a	a	DT
cord-310192-8x37nx4s	234	46	human	human	JJ
cord-310192-8x37nx4s	234	47	coronavirus	coronavirus	NN
cord-310192-8x37nx4s	235	1	(	(	-LRB-
cord-310192-8x37nx4s	235	2	Longhini	Longhini	NNP
cord-310192-8x37nx4s	235	3	et	et	NNP
cord-310192-8x37nx4s	235	4	al	al	NNP
cord-310192-8x37nx4s	235	5	.	.	NNP
cord-310192-8x37nx4s	235	6	,	,	,
cord-310192-8x37nx4s	235	7	2016	2016	CD
cord-310192-8x37nx4s	235	8	)	)	-RRB-
cord-310192-8x37nx4s	235	9	.	.	.
cord-310192-8x37nx4s	236	1	The	the	DT
cord-310192-8x37nx4s	236	2	combination	combination	NN
cord-310192-8x37nx4s	236	3	of	of	IN
cord-310192-8x37nx4s	236	4	these	these	DT
cord-310192-8x37nx4s	236	5	newly	newly	RB
cord-310192-8x37nx4s	236	6	optimized	optimize	VBN
cord-310192-8x37nx4s	236	7	NMR	NMR	NNP
cord-310192-8x37nx4s	236	8	experiments	experiment	NNS
cord-310192-8x37nx4s	236	9	as	as	RB
cord-310192-8x37nx4s	236	10	well	well	RB
cord-310192-8x37nx4s	236	11	as	as	IN
cord-310192-8x37nx4s	236	12	efficient	efficient	JJ
cord-310192-8x37nx4s	236	13	synthesis	synthesis	NN
cord-310192-8x37nx4s	236	14	of	of	IN
cord-310192-8x37nx4s	236	15	position	position	NN
cord-310192-8x37nx4s	236	16	-	-	HYPH
cord-310192-8x37nx4s	236	17	selective	selective	JJ
cord-310192-8x37nx4s	236	18	labeled	label	VBN
cord-310192-8x37nx4s	236	19	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	236	20	,	,	,
cord-310192-8x37nx4s	236	21	conformational	conformational	JJ
cord-310192-8x37nx4s	236	22	exchange	exchange	NN
cord-310192-8x37nx4s	236	23	dynamics	dynamic	NNS
cord-310192-8x37nx4s	236	24	of	of	IN
cord-310192-8x37nx4s	236	25	larger	large	JJR
cord-310192-8x37nx4s	236	26	RNAs	rna	NNS
cord-310192-8x37nx4s	236	27	will	will	MD
cord-310192-8x37nx4s	236	28	become	become	VB
cord-310192-8x37nx4s	236	29	less	less	RBR
cord-310192-8x37nx4s	236	30	challenging	challenging	JJ
cord-310192-8x37nx4s	236	31	and	and	CC
cord-310192-8x37nx4s	236	32	novel	novel	JJ
cord-310192-8x37nx4s	236	33	mechanisms	mechanism	NNS
cord-310192-8x37nx4s	236	34	of	of	IN
cord-310192-8x37nx4s	236	35	RNA	RNA	NNP
cord-310192-8x37nx4s	236	36	regulation	regulation	NN
cord-310192-8x37nx4s	236	37	may	may	MD
cord-310192-8x37nx4s	236	38	be	be	VB
cord-310192-8x37nx4s	236	39	unveiled	unveil	VBN
cord-310192-8x37nx4s	236	40	.	.	.
cord-310192-8x37nx4s	237	1	One	one	CD
cord-310192-8x37nx4s	237	2	of	of	IN
cord-310192-8x37nx4s	237	3	the	the	DT
cord-310192-8x37nx4s	237	4	main	main	JJ
cord-310192-8x37nx4s	237	5	hindrances	hindrance	NNS
cord-310192-8x37nx4s	237	6	of	of	IN
cord-310192-8x37nx4s	237	7	NMR	NMR	NNP
cord-310192-8x37nx4s	237	8	analysis	analysis	NN
cord-310192-8x37nx4s	237	9	of	of	IN
cord-310192-8x37nx4s	237	10	large	large	JJ
cord-310192-8x37nx4s	237	11	RNAs	rna	NNS
cord-310192-8x37nx4s	237	12	is	be	VBZ
cord-310192-8x37nx4s	237	13	the	the	DT
cord-310192-8x37nx4s	237	14	arduous	arduous	JJ
cord-310192-8x37nx4s	237	15	task	task	NN
cord-310192-8x37nx4s	237	16	of	of	IN
cord-310192-8x37nx4s	237	17	assigning	assign	VBG
cord-310192-8x37nx4s	237	18	chemical	chemical	NN
cord-310192-8x37nx4s	237	19	shifts	shift	NNS
cord-310192-8x37nx4s	237	20	.	.	.
cord-310192-8x37nx4s	238	1	Chemical	chemical	NN
cord-310192-8x37nx4s	238	2	shift	shift	NN
cord-310192-8x37nx4s	238	3	assignment	assignment	NN
cord-310192-8x37nx4s	238	4	is	be	VBZ
cord-310192-8x37nx4s	238	5	a	a	DT
cord-310192-8x37nx4s	238	6	prerequisite	prerequisite	NN
cord-310192-8x37nx4s	238	7	for	for	IN
cord-310192-8x37nx4s	238	8	any	any	DT
cord-310192-8x37nx4s	238	9	quantitative	quantitative	JJ
cord-310192-8x37nx4s	238	10	analysis	analysis	NN
cord-310192-8x37nx4s	238	11	of	of	IN
cord-310192-8x37nx4s	238	12	NMR	NMR	NNP
cord-310192-8x37nx4s	238	13	data	datum	NNS
cord-310192-8x37nx4s	238	14	for	for	IN
cord-310192-8x37nx4s	238	15	either	either	DT
cord-310192-8x37nx4s	238	16	structure	structure	NN
cord-310192-8x37nx4s	238	17	determination	determination	NN
cord-310192-8x37nx4s	238	18	or	or	CC
cord-310192-8x37nx4s	238	19	dynamics	dynamic	NNS
cord-310192-8x37nx4s	238	20	studies	study	NNS
cord-310192-8x37nx4s	238	21	.	.	.
cord-310192-8x37nx4s	239	1	In	in	IN
cord-310192-8x37nx4s	239	2	an	an	DT
cord-310192-8x37nx4s	239	3	effort	effort	NN
cord-310192-8x37nx4s	239	4	to	to	TO
cord-310192-8x37nx4s	239	5	establish	establish	VB
cord-310192-8x37nx4s	239	6	the	the	DT
cord-310192-8x37nx4s	239	7	sequence	sequence	NN
cord-310192-8x37nx4s	239	8	and	and	CC
cord-310192-8x37nx4s	239	9	structural	structural	JJ
cord-310192-8x37nx4s	239	10	dependence	dependence	NN
cord-310192-8x37nx4s	239	11	on	on	IN
cord-310192-8x37nx4s	239	12	chemical	chemical	JJ
cord-310192-8x37nx4s	239	13	shift	shift	NN
cord-310192-8x37nx4s	239	14	,	,	,
cord-310192-8x37nx4s	239	15	Johnson	Johnson	NNP
cord-310192-8x37nx4s	239	16	and	and	CC
cord-310192-8x37nx4s	239	17	colleagues	colleague	NNS
cord-310192-8x37nx4s	239	18	analyzed	analyze	VBD
cord-310192-8x37nx4s	239	19	the	the	DT
cord-310192-8x37nx4s	239	20	nonexchangeable	nonexchangeable	JJ
cord-310192-8x37nx4s	239	21	H	H	NNP
cord-310192-8x37nx4s	239	22	8	8	CD
cord-310192-8x37nx4s	239	23	,	,	,
cord-310192-8x37nx4s	239	24	H	H	NNP
cord-310192-8x37nx4s	239	25	2	2	CD
cord-310192-8x37nx4s	239	26	,	,	,
cord-310192-8x37nx4s	239	27	H	H	NNP
cord-310192-8x37nx4s	239	28	6	6	CD
cord-310192-8x37nx4s	239	29	,	,	,
cord-310192-8x37nx4s	239	30	H	H	NNP
cord-310192-8x37nx4s	239	31	5	5	CD
cord-310192-8x37nx4s	239	32	,	,	,
cord-310192-8x37nx4s	239	33	H	h	NN
cord-310192-8x37nx4s	239	34	1	1	CD
cord-310192-8x37nx4s	239	35	0	0	CD
cord-310192-8x37nx4s	239	36	,	,	,
cord-310192-8x37nx4s	239	37	H	h	NN
cord-310192-8x37nx4s	239	38	2	2	CD
cord-310192-8x37nx4s	239	39	0	0	CD
cord-310192-8x37nx4s	239	40	,	,	,
cord-310192-8x37nx4s	239	41	and	and	CC
cord-310192-8x37nx4s	239	42	H	h	NN
cord-310192-8x37nx4s	239	43	3	3	CD
cord-310192-8x37nx4s	239	44	0	0	CD
cord-310192-8x37nx4s	239	45	chemical	chemical	NN
cord-310192-8x37nx4s	239	46	shifts	shift	NNS
cord-310192-8x37nx4s	239	47	for	for	IN
cord-310192-8x37nx4s	239	48	RNAs	rna	NNS
cord-310192-8x37nx4s	239	49	that	that	WDT
cord-310192-8x37nx4s	239	50	have	have	VBP
cord-310192-8x37nx4s	239	51	been	be	VBN
cord-310192-8x37nx4s	239	52	deposited	deposit	VBN
cord-310192-8x37nx4s	239	53	in	in	IN
cord-310192-8x37nx4s	239	54	the	the	DT
cord-310192-8x37nx4s	239	55	publicly	publicly	RB
cord-310192-8x37nx4s	239	56	available	available	JJ
cord-310192-8x37nx4s	239	57	Biological	Biological	NNP
cord-310192-8x37nx4s	239	58	Magnetic	Magnetic	NNP
cord-310192-8x37nx4s	239	59	Resonance	Resonance	NNP
cord-310192-8x37nx4s	239	60	Data	Data	NNP
cord-310192-8x37nx4s	239	61	Bank	Bank	NNP
cord-310192-8x37nx4s	239	62	and	and	CC
cord-310192-8x37nx4s	239	63	have	have	VBP
cord-310192-8x37nx4s	239	64	associated	associate	VBN
cord-310192-8x37nx4s	239	65	structure	structure	NN
cord-310192-8x37nx4s	239	66	coordinates	coordinate	NNS
cord-310192-8x37nx4s	239	67	(	(	-LRB-
cord-310192-8x37nx4s	239	68	Barton	Barton	NNP
cord-310192-8x37nx4s	239	69	,	,	,
cord-310192-8x37nx4s	239	70	Heng	Heng	NNP
cord-310192-8x37nx4s	239	71	,	,	,
cord-310192-8x37nx4s	239	72	Johnson	Johnson	NNP
cord-310192-8x37nx4s	239	73	,	,	,
cord-310192-8x37nx4s	239	74	&	&	CC
cord-310192-8x37nx4s	239	75	Summers	Summers	NNP
cord-310192-8x37nx4s	239	76	,	,	,
cord-310192-8x37nx4s	239	77	2013	2013	CD
cord-310192-8x37nx4s	239	78	;	;	:
cord-310192-8x37nx4s	239	79	Brown	Brown	NNP
cord-310192-8x37nx4s	239	80	,	,	,
cord-310192-8x37nx4s	239	81	Summers	Summers	NNPS
cord-310192-8x37nx4s	239	82	,	,	,
cord-310192-8x37nx4s	239	83	&	&	CC
cord-310192-8x37nx4s	239	84	Johnson	Johnson	NNP
cord-310192-8x37nx4s	239	85	,	,	,
cord-310192-8x37nx4s	239	86	2015	2015	CD
cord-310192-8x37nx4s	239	87	)	)	-RRB-
cord-310192-8x37nx4s	239	88	.	.	.
cord-310192-8x37nx4s	240	1	Here	here	RB
cord-310192-8x37nx4s	240	2	,	,	,
cord-310192-8x37nx4s	240	3	they	-PRON-	PRP
cord-310192-8x37nx4s	240	4	sought	seek	VBD
cord-310192-8x37nx4s	240	5	to	to	TO
cord-310192-8x37nx4s	240	6	identify	identify	VB
cord-310192-8x37nx4s	240	7	structural	structural	JJ
cord-310192-8x37nx4s	240	8	features	feature	NNS
cord-310192-8x37nx4s	240	9	of	of	IN
cord-310192-8x37nx4s	240	10	a	a	DT
cord-310192-8x37nx4s	240	11	given	give	VBN
cord-310192-8x37nx4s	240	12	base	base	NN
cord-310192-8x37nx4s	240	13	pair	pair	NN
cord-310192-8x37nx4s	240	14	triplet	triplet	NN
cord-310192-8x37nx4s	240	15	and	and	CC
cord-310192-8x37nx4s	240	16	examined	examine	VBD
cord-310192-8x37nx4s	240	17	how	how	WRB
cord-310192-8x37nx4s	240	18	the	the	DT
cord-310192-8x37nx4s	240	19	chemical	chemical	JJ
cord-310192-8x37nx4s	240	20	shift	shift	NN
cord-310192-8x37nx4s	240	21	of	of	IN
cord-310192-8x37nx4s	240	22	a	a	DT
cord-310192-8x37nx4s	240	23	given	give	VBN
cord-310192-8x37nx4s	240	24	nuclei	nucleus	NNS
cord-310192-8x37nx4s	240	25	is	be	VBZ
cord-310192-8x37nx4s	240	26	affected	affect	VBN
cord-310192-8x37nx4s	240	27	by	by	IN
cord-310192-8x37nx4s	240	28	changes	change	NNS
cord-310192-8x37nx4s	240	29	in	in	IN
cord-310192-8x37nx4s	240	30	the	the	DT
cord-310192-8x37nx4s	240	31	local	local	JJ
cord-310192-8x37nx4s	240	32	structural	structural	JJ
cord-310192-8x37nx4s	240	33	environment	environment	NN
cord-310192-8x37nx4s	240	34	.	.	.
cord-310192-8x37nx4s	241	1	These	these	DT
cord-310192-8x37nx4s	241	2	database	database	NN
cord-310192-8x37nx4s	241	3	prediction	prediction	NN
cord-310192-8x37nx4s	241	4	tools	tool	NNS
cord-310192-8x37nx4s	241	5	can	can	MD
cord-310192-8x37nx4s	241	6	facilitate	facilitate	VB
cord-310192-8x37nx4s	241	7	the	the	DT
cord-310192-8x37nx4s	241	8	validation	validation	NN
cord-310192-8x37nx4s	241	9	of	of	IN
cord-310192-8x37nx4s	241	10	experimentally	experimentally	RB
cord-310192-8x37nx4s	241	11	derived	derive	VBN
cord-310192-8x37nx4s	241	12	assignments	assignment	NNS
cord-310192-8x37nx4s	241	13	and	and	CC
cord-310192-8x37nx4s	241	14	aid	aid	NN
cord-310192-8x37nx4s	241	15	in	in	IN
cord-310192-8x37nx4s	241	16	the	the	DT
cord-310192-8x37nx4s	241	17	manual	manual	JJ
cord-310192-8x37nx4s	241	18	assignment	assignment	NN
cord-310192-8x37nx4s	241	19	of	of	IN
cord-310192-8x37nx4s	241	20	NMR	NMR	NNP
cord-310192-8x37nx4s	241	21	data	datum	NNS
cord-310192-8x37nx4s	241	22	collected	collect	VBN
cord-310192-8x37nx4s	241	23	on	on	IN
cord-310192-8x37nx4s	241	24	large	large	JJ
cord-310192-8x37nx4s	241	25	RNA	RNA	NNP
cord-310192-8x37nx4s	241	26	molecules	molecule	NNS
cord-310192-8x37nx4s	241	27	.	.	.
cord-310192-8x37nx4s	242	1	While	while	IN
cord-310192-8x37nx4s	242	2	advancements	advancement	NNS
cord-310192-8x37nx4s	242	3	have	have	VBP
cord-310192-8x37nx4s	242	4	been	be	VBN
cord-310192-8x37nx4s	242	5	made	make	VBN
cord-310192-8x37nx4s	242	6	to	to	TO
cord-310192-8x37nx4s	242	7	facilitate	facilitate	VB
cord-310192-8x37nx4s	242	8	the	the	DT
cord-310192-8x37nx4s	242	9	study	study	NN
cord-310192-8x37nx4s	242	10	of	of	IN
cord-310192-8x37nx4s	242	11	large	large	JJ
cord-310192-8x37nx4s	242	12	RNA	RNA	NNP
cord-310192-8x37nx4s	242	13	structure	structure	NN
cord-310192-8x37nx4s	242	14	and	and	CC
cord-310192-8x37nx4s	242	15	dynamics	dynamic	NNS
cord-310192-8x37nx4s	242	16	by	by	IN
cord-310192-8x37nx4s	242	17	NMR	NMR	NNP
cord-310192-8x37nx4s	242	18	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	242	19	,	,	,
cord-310192-8x37nx4s	242	20	complimentary	complimentary	JJ
cord-310192-8x37nx4s	242	21	structural	structural	JJ
cord-310192-8x37nx4s	242	22	techniques	technique	NNS
cord-310192-8x37nx4s	242	23	have	have	VBP
cord-310192-8x37nx4s	242	24	proven	prove	VBN
cord-310192-8x37nx4s	242	25	incredibly	incredibly	RB
cord-310192-8x37nx4s	242	26	useful	useful	JJ
cord-310192-8x37nx4s	242	27	for	for	IN
cord-310192-8x37nx4s	242	28	providing	provide	VBG
cord-310192-8x37nx4s	242	29	additional	additional	JJ
cord-310192-8x37nx4s	242	30	global	global	JJ
cord-310192-8x37nx4s	242	31	structural	structural	JJ
cord-310192-8x37nx4s	242	32	restraints	restraint	NNS
cord-310192-8x37nx4s	242	33	.	.	.
cord-310192-8x37nx4s	243	1	Small	small	JJ
cord-310192-8x37nx4s	243	2	-	-	HYPH
cord-310192-8x37nx4s	243	3	angle	angle	NN
cord-310192-8x37nx4s	243	4	X	x	NN
cord-310192-8x37nx4s	243	5	-	-	NN
cord-310192-8x37nx4s	243	6	ray	ray	NN
cord-310192-8x37nx4s	243	7	scattering	scattering	NN
cord-310192-8x37nx4s	243	8	(	(	-LRB-
cord-310192-8x37nx4s	243	9	SAXS	SAXS	NNP
cord-310192-8x37nx4s	243	10	)	)	-RRB-
cord-310192-8x37nx4s	243	11	has	have	VBZ
cord-310192-8x37nx4s	243	12	been	be	VBN
cord-310192-8x37nx4s	243	13	widely	widely	RB
cord-310192-8x37nx4s	243	14	used	use	VBN
cord-310192-8x37nx4s	243	15	in	in	IN
cord-310192-8x37nx4s	243	16	combination	combination	NN
cord-310192-8x37nx4s	243	17	with	with	IN
cord-310192-8x37nx4s	243	18	NMR	NMR	NNP
cord-310192-8x37nx4s	243	19	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	243	20	to	to	TO
cord-310192-8x37nx4s	243	21	refine	refine	VB
cord-310192-8x37nx4s	243	22	NMR	nmr	NN
cord-310192-8x37nx4s	243	23	-	-	HYPH
cord-310192-8x37nx4s	243	24	derived	derive	VBN
cord-310192-8x37nx4s	243	25	structural	structural	JJ
cord-310192-8x37nx4s	243	26	ensembles	ensemble	NNS
cord-310192-8x37nx4s	243	27	(	(	-LRB-
cord-310192-8x37nx4s	243	28	Burke	Burke	NNP
cord-310192-8x37nx4s	243	29	et	et	NNP
cord-310192-8x37nx4s	243	30	al	al	NNP
cord-310192-8x37nx4s	243	31	.	.	NNP
cord-310192-8x37nx4s	243	32	,	,	,
cord-310192-8x37nx4s	243	33	2012	2012	CD
cord-310192-8x37nx4s	243	34	;	;	.
cord-310192-8x37nx4s	244	1	Cornilescu	Cornilescu	NNP
cord-310192-8x37nx4s	244	2	et	et	FW
cord-310192-8x37nx4s	244	3	al	al	NNP
cord-310192-8x37nx4s	244	4	.	.	NNP
cord-310192-8x37nx4s	244	5	,	,	,
cord-310192-8x37nx4s	244	6	2016	2016	CD
cord-310192-8x37nx4s	244	7	;	;	.
cord-310192-8x37nx4s	245	1	Grishaev	Grishaev	NNP
cord-310192-8x37nx4s	245	2	,	,	,
cord-310192-8x37nx4s	245	3	Ying	Ying	NNP
cord-310192-8x37nx4s	245	4	,	,	,
cord-310192-8x37nx4s	245	5	Canny	canny	JJ
cord-310192-8x37nx4s	245	6	,	,	,
cord-310192-8x37nx4s	245	7	Pardi	Pardi	NNP
cord-310192-8x37nx4s	245	8	,	,	,
cord-310192-8x37nx4s	245	9	&	&	CC
cord-310192-8x37nx4s	245	10	Bax	Bax	NNP
cord-310192-8x37nx4s	245	11	,	,	,
cord-310192-8x37nx4s	245	12	2008	2008	CD
cord-310192-8x37nx4s	245	13	;	;	:
cord-310192-8x37nx4s	245	14	Imai	Imai	NNP
cord-310192-8x37nx4s	245	15	et	et	NNP
cord-310192-8x37nx4s	245	16	al	al	NNP
cord-310192-8x37nx4s	245	17	.	.	NNP
cord-310192-8x37nx4s	245	18	,	,	,
cord-310192-8x37nx4s	245	19	2016	2016	CD
cord-310192-8x37nx4s	245	20	;	;	:
cord-310192-8x37nx4s	245	21	Jain	Jain	NNP
cord-310192-8x37nx4s	245	22	et	et	NNP
cord-310192-8x37nx4s	245	23	al	al	NNP
cord-310192-8x37nx4s	245	24	.	.	NNP
cord-310192-8x37nx4s	245	25	,	,	,
cord-310192-8x37nx4s	245	26	2016	2016	CD
cord-310192-8x37nx4s	245	27	;	;	:
cord-310192-8x37nx4s	245	28	Zuo	Zuo	NNP
cord-310192-8x37nx4s	245	29	et	et	FW
cord-310192-8x37nx4s	245	30	al	al	NNP
cord-310192-8x37nx4s	245	31	.	.	NNP
cord-310192-8x37nx4s	245	32	,	,	,
cord-310192-8x37nx4s	245	33	2010	2010	CD
cord-310192-8x37nx4s	245	34	)	)	-RRB-
cord-310192-8x37nx4s	245	35	.	.	.
cord-310192-8x37nx4s	246	1	In	in	IN
cord-310192-8x37nx4s	246	2	fact	fact	NN
cord-310192-8x37nx4s	246	3	,	,	,
cord-310192-8x37nx4s	246	4	studies	study	NNS
cord-310192-8x37nx4s	246	5	show	show	VBP
cord-310192-8x37nx4s	246	6	that	that	IN
cord-310192-8x37nx4s	246	7	SAXS	SAXS	NNP
cord-310192-8x37nx4s	246	8	can	can	MD
cord-310192-8x37nx4s	246	9	be	be	VB
cord-310192-8x37nx4s	246	10	combined	combine	VBN
cord-310192-8x37nx4s	246	11	with	with	IN
cord-310192-8x37nx4s	246	12	sparse	sparse	JJ
cord-310192-8x37nx4s	246	13	RDC	RDC	NNP
cord-310192-8x37nx4s	246	14	restraints	restraint	NNS
cord-310192-8x37nx4s	246	15	to	to	TO
cord-310192-8x37nx4s	246	16	accurately	accurately	RB
cord-310192-8x37nx4s	246	17	refine	refine	VB
cord-310192-8x37nx4s	246	18	idealized	idealized	JJ
cord-310192-8x37nx4s	246	19	/	/	SYM
cord-310192-8x37nx4s	246	20	modeled	model	VBN
cord-310192-8x37nx4s	246	21	RNA	RNA	NNP
cord-310192-8x37nx4s	246	22	structures	structure	NNS
cord-310192-8x37nx4s	246	23	(	(	-LRB-
cord-310192-8x37nx4s	246	24	Grishaev	Grishaev	NNP
cord-310192-8x37nx4s	246	25	et	et	NNP
cord-310192-8x37nx4s	246	26	al	al	NNP
cord-310192-8x37nx4s	246	27	.	.	NNP
cord-310192-8x37nx4s	246	28	,	,	,
cord-310192-8x37nx4s	246	29	2008	2008	CD
cord-310192-8x37nx4s	246	30	;	;	:
cord-310192-8x37nx4s	246	31	Wang	Wang	NNP
cord-310192-8x37nx4s	246	32	et	et	NNP
cord-310192-8x37nx4s	246	33	al	al	NNP
cord-310192-8x37nx4s	246	34	.	.	NNP
cord-310192-8x37nx4s	246	35	,	,	,
cord-310192-8x37nx4s	246	36	2009	2009	CD
cord-310192-8x37nx4s	246	37	)	)	-RRB-
cord-310192-8x37nx4s	246	38	.	.	.
cord-310192-8x37nx4s	247	1	Another	another	DT
cord-310192-8x37nx4s	247	2	approach	approach	NN
cord-310192-8x37nx4s	247	3	is	be	VBZ
cord-310192-8x37nx4s	247	4	to	to	TO
cord-310192-8x37nx4s	247	5	refine	refine	VB
cord-310192-8x37nx4s	247	6	NMR	NMR	NNP
cord-310192-8x37nx4s	247	7	structures	structure	NNS
cord-310192-8x37nx4s	247	8	with	with	IN
cord-310192-8x37nx4s	247	9	a	a	DT
cord-310192-8x37nx4s	247	10	cryo	cryo	NN
cord-310192-8x37nx4s	247	11	-	-	HYPH
cord-310192-8x37nx4s	247	12	electron	electron	NN
cord-310192-8x37nx4s	247	13	microscopy	microscopy	NN
cord-310192-8x37nx4s	247	14	density	density	NN
cord-310192-8x37nx4s	247	15	map	map	NN
cord-310192-8x37nx4s	247	16	.	.	.
cord-310192-8x37nx4s	248	1	This	this	DT
cord-310192-8x37nx4s	248	2	approach	approach	NN
cord-310192-8x37nx4s	248	3	has	have	VBZ
cord-310192-8x37nx4s	248	4	been	be	VBN
cord-310192-8x37nx4s	248	5	applied	apply	VBN
cord-310192-8x37nx4s	248	6	to	to	IN
cord-310192-8x37nx4s	248	7	both	both	CC
cord-310192-8x37nx4s	248	8	relatively	relatively	RB
cord-310192-8x37nx4s	248	9	large	large	JJ
cord-310192-8x37nx4s	248	10	and	and	CC
cord-310192-8x37nx4s	248	11	small	small	JJ
cord-310192-8x37nx4s	248	12	RNAs	rna	NNS
cord-310192-8x37nx4s	248	13	(	(	-LRB-
cord-310192-8x37nx4s	248	14	Gong	Gong	NNP
cord-310192-8x37nx4s	248	15	,	,	,
cord-310192-8x37nx4s	248	16	Schwieters	Schwieters	NNPS
cord-310192-8x37nx4s	248	17	,	,	,
cord-310192-8x37nx4s	248	18	&	&	CC
cord-310192-8x37nx4s	248	19	Tang	Tang	NNP
cord-310192-8x37nx4s	248	20	,	,	,
cord-310192-8x37nx4s	248	21	2015	2015	CD
cord-310192-8x37nx4s	248	22	;	;	:
cord-310192-8x37nx4s	248	23	Miyazaki	Miyazaki	NNP
cord-310192-8x37nx4s	248	24	et	et	NNP
cord-310192-8x37nx4s	248	25	al	al	NNP
cord-310192-8x37nx4s	248	26	.	.	.
cord-310192-8x37nx4s	249	1	,	,	,
cord-310192-8x37nx4s	249	2	2010	2010	CD
cord-310192-8x37nx4s	249	3	;	;	:
cord-310192-8x37nx4s	249	4	Zhang	Zhang	NNP
cord-310192-8x37nx4s	249	5	et	et	NNP
cord-310192-8x37nx4s	249	6	al	al	NNP
cord-310192-8x37nx4s	249	7	.	.	NNP
cord-310192-8x37nx4s	249	8	,	,	,
cord-310192-8x37nx4s	249	9	2018	2018	CD
cord-310192-8x37nx4s	249	10	)	)	-RRB-
cord-310192-8x37nx4s	249	11	and	and	CC
cord-310192-8x37nx4s	249	12	will	will	MD
cord-310192-8x37nx4s	249	13	likely	likely	RB
cord-310192-8x37nx4s	249	14	be	be	VB
cord-310192-8x37nx4s	249	15	a	a	DT
cord-310192-8x37nx4s	249	16	necessary	necessary	JJ
cord-310192-8x37nx4s	249	17	complement	complement	NN
cord-310192-8x37nx4s	249	18	to	to	IN
cord-310192-8x37nx4s	249	19	structural	structural	JJ
cord-310192-8x37nx4s	249	20	studies	study	NNS
cord-310192-8x37nx4s	249	21	as	as	IN
cord-310192-8x37nx4s	249	22	the	the	DT
cord-310192-8x37nx4s	249	23	size	size	NN
cord-310192-8x37nx4s	249	24	of	of	IN
cord-310192-8x37nx4s	249	25	the	the	DT
cord-310192-8x37nx4s	249	26	RNA	RNA	NNP
cord-310192-8x37nx4s	249	27	being	be	VBG
cord-310192-8x37nx4s	249	28	investigated	investigate	VBN
cord-310192-8x37nx4s	249	29	increases	increase	NNS
cord-310192-8x37nx4s	249	30	.	.	.
cord-310192-8x37nx4s	250	1	Zika	Zika	NNP
cord-310192-8x37nx4s	250	2	virus	virus	NN
cord-310192-8x37nx4s	250	3	produces	produce	VBZ
cord-310192-8x37nx4s	250	4	noncoding	noncoding	JJ
cord-310192-8x37nx4s	250	5	RNAs	rna	NNS
cord-310192-8x37nx4s	250	6	using	use	VBG
cord-310192-8x37nx4s	250	7	a	a	DT
cord-310192-8x37nx4s	250	8	multi	multi	JJ
cord-310192-8x37nx4s	250	9	-	-	JJ
cord-310192-8x37nx4s	250	10	pseudoknot	pseudoknot	JJ
cord-310192-8x37nx4s	250	11	structure	structure	NN
cord-310192-8x37nx4s	250	12	that	that	WDT
cord-310192-8x37nx4s	250	13	confounds	confound	VBZ
cord-310192-8x37nx4s	250	14	a	a	DT
cord-310192-8x37nx4s	250	15	cellular	cellular	JJ
cord-310192-8x37nx4s	250	16	exonuclease	exonuclease	NN
cord-310192-8x37nx4s	250	17	NMR	nmr	NN
cord-310192-8x37nx4s	250	18	studies	study	NNS
cord-310192-8x37nx4s	250	19	of	of	IN
cord-310192-8x37nx4s	250	20	nucleic	nucleic	JJ
cord-310192-8x37nx4s	250	21	acid	acid	NN
cord-310192-8x37nx4s	250	22	dynamics	dynamic	NNS
cord-310192-8x37nx4s	250	23	RNA	RNA	NNP
cord-310192-8x37nx4s	250	24	dynamics	dynamic	NNS
cord-310192-8x37nx4s	250	25	:	:	:
cord-310192-8x37nx4s	250	26	It	-PRON-	PRP
cord-310192-8x37nx4s	250	27	is	be	VBZ
cord-310192-8x37nx4s	250	28	about	about	IN
cord-310192-8x37nx4s	250	29	time	time	NN
cord-310192-8x37nx4s	250	30	Regio	regio	NN
cord-310192-8x37nx4s	250	31	-	-	HYPH
cord-310192-8x37nx4s	250	32	selective	selective	JJ
cord-310192-8x37nx4s	250	33	chemical	chemical	NN
cord-310192-8x37nx4s	250	34	-	-	HYPH
cord-310192-8x37nx4s	250	35	enzymatic	enzymatic	JJ
cord-310192-8x37nx4s	250	36	synthesis	synthesis	NN
cord-310192-8x37nx4s	250	37	of	of	IN
cord-310192-8x37nx4s	250	38	pyrimidine	pyrimidine	NN
cord-310192-8x37nx4s	250	39	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	250	40	facilitates	facilitate	VBZ
cord-310192-8x37nx4s	250	41	RNA	RNA	NNP
cord-310192-8x37nx4s	250	42	structure	structure	NN
cord-310192-8x37nx4s	250	43	and	and	CC
cord-310192-8x37nx4s	250	44	dynamics	dynamic	NNS
cord-310192-8x37nx4s	250	45	studies	study	NNS
cord-310192-8x37nx4s	250	46	Global	global	JJ
cord-310192-8x37nx4s	250	47	shape	shape	NN
cord-310192-8x37nx4s	250	48	mimicry	mimicry	NN
cord-310192-8x37nx4s	250	49	of	of	IN
cord-310192-8x37nx4s	250	50	tRNA	trna	NN
cord-310192-8x37nx4s	250	51	within	within	IN
cord-310192-8x37nx4s	250	52	a	a	DT
cord-310192-8x37nx4s	250	53	viral	viral	JJ
cord-310192-8x37nx4s	250	54	internal	internal	JJ
cord-310192-8x37nx4s	250	55	ribosome	ribosome	NN
cord-310192-8x37nx4s	250	56	entry	entry	NN
cord-310192-8x37nx4s	250	57	site	site	NN
cord-310192-8x37nx4s	250	58	mediates	mediate	VBZ
cord-310192-8x37nx4s	250	59	translational	translational	JJ
cord-310192-8x37nx4s	250	60	reading	reading	NN
cord-310192-8x37nx4s	250	61	frame	frame	NN
cord-310192-8x37nx4s	250	62	selection	selection	NN
cord-310192-8x37nx4s	250	63	Characterizing	characterize	VBG
cord-310192-8x37nx4s	250	64	the	the	DT
cord-310192-8x37nx4s	250	65	relative	relative	JJ
cord-310192-8x37nx4s	250	66	orientation	orientation	NN
cord-310192-8x37nx4s	250	67	and	and	CC
cord-310192-8x37nx4s	250	68	dynamics	dynamic	NNS
cord-310192-8x37nx4s	250	69	of	of	IN
cord-310192-8x37nx4s	250	70	RNA	RNA	NNP
cord-310192-8x37nx4s	250	71	A	A	NNP
cord-310192-8x37nx4s	250	72	-	-	HYPH
cord-310192-8x37nx4s	250	73	form	form	NN
cord-310192-8x37nx4s	250	74	helices	helix	NNS
cord-310192-8x37nx4s	250	75	using	use	VBG
cord-310192-8x37nx4s	250	76	NMR	NMR	NNP
cord-310192-8x37nx4s	250	77	residual	residual	JJ
cord-310192-8x37nx4s	250	78	dipolar	dipolar	JJ
cord-310192-8x37nx4s	250	79	couplings	coupling	NNS
cord-310192-8x37nx4s	250	80	Discrete	discrete	JJ
cord-310192-8x37nx4s	250	81	structure	structure	NN
cord-310192-8x37nx4s	250	82	of	of	IN
cord-310192-8x37nx4s	250	83	an	an	DT
cord-310192-8x37nx4s	250	84	RNA	RNA	NNP
cord-310192-8x37nx4s	250	85	folding	folding	NN
cord-310192-8x37nx4s	250	86	intermediate	intermediate	NN
cord-310192-8x37nx4s	250	87	revealed	reveal	VBN
cord-310192-8x37nx4s	250	88	by	by	IN
cord-310192-8x37nx4s	250	89	cryo	cryo	NN
cord-310192-8x37nx4s	250	90	-	-	HYPH
cord-310192-8x37nx4s	250	91	electron	electron	NN
cord-310192-8x37nx4s	250	92	microscopy	microscopy	NN
cord-310192-8x37nx4s	250	93	Structure	structure	NN
cord-310192-8x37nx4s	250	94	and	and	CC
cord-310192-8x37nx4s	250	95	mechanism	mechanism	NN
cord-310192-8x37nx4s	250	96	of	of	IN
cord-310192-8x37nx4s	250	97	a	a	DT
cord-310192-8x37nx4s	250	98	molecular	molecular	JJ
cord-310192-8x37nx4s	250	99	rheostat	rheostat	NN
cord-310192-8x37nx4s	250	100	,	,	,
cord-310192-8x37nx4s	250	101	an	an	DT
cord-310192-8x37nx4s	250	102	RNA	RNA	NNP
cord-310192-8x37nx4s	250	103	thermometer	thermometer	NN
cord-310192-8x37nx4s	250	104	that	that	WDT
cord-310192-8x37nx4s	250	105	modulates	modulate	VBZ
cord-310192-8x37nx4s	250	106	immune	immune	JJ
cord-310192-8x37nx4s	250	107	evasion	evasion	NN
cord-310192-8x37nx4s	250	108	by	by	IN
cord-310192-8x37nx4s	250	109	Neisseria	Neisseria	NNP
cord-310192-8x37nx4s	250	110	meningitidis	meningitidis	NNP
cord-310192-8x37nx4s	250	111	Database	Database	NNP
cord-310192-8x37nx4s	250	112	proton	proton	NN
cord-310192-8x37nx4s	250	113	NMR	NMR	NNP
cord-310192-8x37nx4s	250	114	chemical	chemical	NN
cord-310192-8x37nx4s	250	115	shifts	shift	NNS
cord-310192-8x37nx4s	250	116	for	for	IN
cord-310192-8x37nx4s	250	117	RNA	RNA	NNP
cord-310192-8x37nx4s	250	118	signal	signal	NN
cord-310192-8x37nx4s	250	119	assignment	assignment	NN
cord-310192-8x37nx4s	250	120	and	and	CC
cord-310192-8x37nx4s	250	121	validation	validation	NN
cord-310192-8x37nx4s	250	122	Preparation	preparation	NN
cord-310192-8x37nx4s	250	123	of	of	IN
cord-310192-8x37nx4s	250	124	isotopically	isotopically	RB
cord-310192-8x37nx4s	250	125	enriched	enrich	VBN
cord-310192-8x37nx4s	250	126	RNAs	rna	NNS
cord-310192-8x37nx4s	250	127	for	for	IN
cord-310192-8x37nx4s	250	128	heteronuclear	heteronuclear	NN
cord-310192-8x37nx4s	250	129	NMR	NMR	NNP
cord-310192-8x37nx4s	250	130	Preparation	Preparation	NNP
cord-310192-8x37nx4s	250	131	of	of	IN
cord-310192-8x37nx4s	250	132	isotopically	isotopically	RB
cord-310192-8x37nx4s	250	133	labeled	label	VBN
cord-310192-8x37nx4s	250	134	ribonucleotides	ribonucleotide	NNS
cord-310192-8x37nx4s	250	135	for	for	IN
cord-310192-8x37nx4s	250	136	multidimensional	multidimensional	JJ
cord-310192-8x37nx4s	250	137	NMR	NMR	NNP
cord-310192-8x37nx4s	250	138	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	250	139	of	of	IN
cord-310192-8x37nx4s	250	140	RNA	RNA	NNP
cord-310192-8x37nx4s	251	1	The	the	DT
cord-310192-8x37nx4s	251	2	Protein	Protein	NNP
cord-310192-8x37nx4s	251	3	Data	Data	NNP
cord-310192-8x37nx4s	251	4	Bank	Bank	NNP
cord-310192-8x37nx4s	251	5	Improving	Improving	NNP
cord-310192-8x37nx4s	251	6	NMR	NMR	NNP
cord-310192-8x37nx4s	251	7	structures	structure	NNS
cord-310192-8x37nx4s	251	8	of	of	IN
cord-310192-8x37nx4s	251	9	RNA	RNA	NNP
cord-310192-8x37nx4s	251	10	Genome	Genome	NNP
cord-310192-8x37nx4s	251	11	-	-	HYPH
cord-310192-8x37nx4s	251	12	wide	wide	JJ
cord-310192-8x37nx4s	251	13	analysis	analysis	NN
cord-310192-8x37nx4s	251	14	of	of	IN
cord-310192-8x37nx4s	251	15	RNA	RNA	NNP
cord-310192-8x37nx4s	251	16	secondary	secondary	JJ
cord-310192-8x37nx4s	251	17	structure	structure	NN
cord-310192-8x37nx4s	251	18	Regulation	regulation	NN
cord-310192-8x37nx4s	251	19	of	of	IN
cord-310192-8x37nx4s	251	20	transcription	transcription	NN
cord-310192-8x37nx4s	251	21	by	by	IN
cord-310192-8x37nx4s	251	22	long	long	JJ
cord-310192-8x37nx4s	251	23	noncoding	noncoding	JJ
cord-310192-8x37nx4s	251	24	RNAs	rna	NNS
cord-310192-8x37nx4s	251	25	Characterizing	characterize	VBG
cord-310192-8x37nx4s	251	26	RNA	RNA	NNP
cord-310192-8x37nx4s	251	27	dynamics	dynamic	NNS
cord-310192-8x37nx4s	251	28	at	at	IN
cord-310192-8x37nx4s	251	29	atomic	atomic	JJ
cord-310192-8x37nx4s	251	30	resolution	resolution	NN
cord-310192-8x37nx4s	251	31	using	use	VBG
cord-310192-8x37nx4s	251	32	solution	solution	NN
cord-310192-8x37nx4s	251	33	-	-	HYPH
cord-310192-8x37nx4s	251	34	state	state	NN
cord-310192-8x37nx4s	251	35	NMR	NMR	NNP
cord-310192-8x37nx4s	251	36	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	251	37	Prediction	Prediction	NNP
cord-310192-8x37nx4s	251	38	of	of	IN
cord-310192-8x37nx4s	251	39	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	251	40	and	and	CC
cord-310192-8x37nx4s	251	41	carbon	carbon	NN
cord-310192-8x37nx4s	251	42	chemical	chemical	NN
cord-310192-8x37nx4s	251	43	shifts	shift	NNS
cord-310192-8x37nx4s	251	44	from	from	IN
cord-310192-8x37nx4s	251	45	RNA	RNA	NNP
cord-310192-8x37nx4s	251	46	using	use	VBG
cord-310192-8x37nx4s	251	47	database	database	NN
cord-310192-8x37nx4s	251	48	mining	mining	NN
cord-310192-8x37nx4s	251	49	and	and	CC
cord-310192-8x37nx4s	251	50	support	support	NN
cord-310192-8x37nx4s	251	51	vector	vector	NN
cord-310192-8x37nx4s	251	52	regression	regression	NN
cord-310192-8x37nx4s	251	53	Structure	structure	NN
cord-310192-8x37nx4s	251	54	of	of	IN
cord-310192-8x37nx4s	251	55	the	the	DT
cord-310192-8x37nx4s	251	56	yeast	yeast	NN
cord-310192-8x37nx4s	251	57	U2	U2	NNP
cord-310192-8x37nx4s	251	58	/	/	SYM
cord-310192-8x37nx4s	251	59	U6	U6	NNP
cord-310192-8x37nx4s	251	60	snRNA	snrna	NN
cord-310192-8x37nx4s	251	61	complex	complex	JJ
cord-310192-8x37nx4s	251	62	Structural	structural	JJ
cord-310192-8x37nx4s	251	63	basis	basis	NN
cord-310192-8x37nx4s	251	64	for	for	IN
cord-310192-8x37nx4s	251	65	the	the	DT
cord-310192-8x37nx4s	251	66	second	second	JJ
cord-310192-8x37nx4s	251	67	step	step	NN
cord-310192-8x37nx4s	251	68	of	of	IN
cord-310192-8x37nx4s	251	69	group	group	NN
cord-310192-8x37nx4s	251	70	II	II	NNP
cord-310192-8x37nx4s	251	71	intron	intron	NN
cord-310192-8x37nx4s	251	72	splicing	splice	VBG
cord-310192-8x37nx4s	251	73	Measurement	Measurement	NNP
cord-310192-8x37nx4s	251	74	of	of	IN
cord-310192-8x37nx4s	251	75	residual	residual	JJ
cord-310192-8x37nx4s	251	76	dipolar	dipolar	JJ
cord-310192-8x37nx4s	251	77	couplings	coupling	NNS
cord-310192-8x37nx4s	251	78	of	of	IN
cord-310192-8x37nx4s	251	79	macromolecules	macromolecule	NNS
cord-310192-8x37nx4s	251	80	aligned	align	VBN
cord-310192-8x37nx4s	251	81	in	in	IN
cord-310192-8x37nx4s	251	82	the	the	DT
cord-310192-8x37nx4s	251	83	nematic	nematic	JJ
cord-310192-8x37nx4s	251	84	phase	phase	NN
cord-310192-8x37nx4s	251	85	of	of	IN
cord-310192-8x37nx4s	251	86	a	a	DT
cord-310192-8x37nx4s	251	87	colloidal	colloidal	JJ
cord-310192-8x37nx4s	251	88	suspension	suspension	NN
cord-310192-8x37nx4s	251	89	of	of	IN
cord-310192-8x37nx4s	251	90	rod	rod	NN
cord-310192-8x37nx4s	251	91	-	-	HYPH
cord-310192-8x37nx4s	251	92	shaped	shape	VBN
cord-310192-8x37nx4s	251	93	viruses	virus	NNS
cord-310192-8x37nx4s	252	1	Quantitative	quantitative	JJ
cord-310192-8x37nx4s	252	2	dimethyl	dimethyl	NN
cord-310192-8x37nx4s	252	3	sulfate	sulfate	NN
cord-310192-8x37nx4s	252	4	mapping	mapping	NN
cord-310192-8x37nx4s	252	5	for	for	IN
cord-310192-8x37nx4s	252	6	automated	automate	VBN
cord-310192-8x37nx4s	252	7	RNA	RNA	NNP
cord-310192-8x37nx4s	252	8	secondary	secondary	JJ
cord-310192-8x37nx4s	252	9	structure	structure	NN
cord-310192-8x37nx4s	252	10	inference	inference	NN
cord-310192-8x37nx4s	252	11	Structural	structural	JJ
cord-310192-8x37nx4s	252	12	analysis	analysis	NN
cord-310192-8x37nx4s	252	13	of	of	IN
cord-310192-8x37nx4s	252	14	multi	multi	JJ
cord-310192-8x37nx4s	252	15	-	-	JJ
cord-310192-8x37nx4s	252	16	helical	helical	JJ
cord-310192-8x37nx4s	252	17	RNAs	rna	NNS
cord-310192-8x37nx4s	252	18	by	by	IN
cord-310192-8x37nx4s	252	19	NMR	NMR	NNP
cord-310192-8x37nx4s	252	20	-	-	HYPH
cord-310192-8x37nx4s	252	21	SAXS	SAXS	NNP
cord-310192-8x37nx4s	252	22	/	/	SYM
cord-310192-8x37nx4s	252	23	WAXS	WAXS	NNP
cord-310192-8x37nx4s	252	24	:	:	:
cord-310192-8x37nx4s	253	1	Application	application	NN
cord-310192-8x37nx4s	253	2	to	to	IN
cord-310192-8x37nx4s	253	3	the	the	DT
cord-310192-8x37nx4s	253	4	U4	U4	NNP
cord-310192-8x37nx4s	253	5	/	/	SYM
cord-310192-8x37nx4s	253	6	U6	U6	NNP
cord-310192-8x37nx4s	253	7	di	di	NNP
cord-310192-8x37nx4s	253	8	-	-	HYPH
cord-310192-8x37nx4s	253	9	snRNA	snrna	NN
cord-310192-8x37nx4s	253	10	Crystal	Crystal	NNP
cord-310192-8x37nx4s	253	11	structures	structure	NNS
cord-310192-8x37nx4s	253	12	of	of	IN
cord-310192-8x37nx4s	253	13	a	a	DT
cord-310192-8x37nx4s	253	14	group	group	NN
cord-310192-8x37nx4s	253	15	II	II	NNP
cord-310192-8x37nx4s	253	16	intron	intron	NN
cord-310192-8x37nx4s	253	17	lariat	lariat	NN
cord-310192-8x37nx4s	253	18	primed	prime	VBD
cord-310192-8x37nx4s	253	19	for	for	IN
cord-310192-8x37nx4s	253	20	reverse	reverse	JJ
cord-310192-8x37nx4s	253	21	splicing	splice	VBG
cord-310192-8x37nx4s	253	22	Efficient	efficient	JJ
cord-310192-8x37nx4s	253	23	detection	detection	NN
cord-310192-8x37nx4s	253	24	of	of	IN
cord-310192-8x37nx4s	253	25	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	253	26	bonds	bond	NNS
cord-310192-8x37nx4s	253	27	in	in	IN
cord-310192-8x37nx4s	253	28	dynamic	dynamic	JJ
cord-310192-8x37nx4s	253	29	regions	region	NNS
cord-310192-8x37nx4s	253	30	of	of	IN
cord-310192-8x37nx4s	253	31	RNA	RNA	NNP
cord-310192-8x37nx4s	253	32	by	by	IN
cord-310192-8x37nx4s	253	33	sensitivity	sensitivity	NN
cord-310192-8x37nx4s	253	34	-	-	HYPH
cord-310192-8x37nx4s	253	35	optimized	optimize	VBN
cord-310192-8x37nx4s	253	36	NMR	NMR	NNP
cord-310192-8x37nx4s	253	37	pulse	pulse	NN
cord-310192-8x37nx4s	253	38	sequences	sequence	NNS
cord-310192-8x37nx4s	254	1	RNA	RNA	NNP
cord-310192-8x37nx4s	254	2	helical	helical	JJ
cord-310192-8x37nx4s	254	3	packing	packing	NN
cord-310192-8x37nx4s	254	4	in	in	IN
cord-310192-8x37nx4s	254	5	solution	solution	NN
cord-310192-8x37nx4s	254	6	:	:	:
cord-310192-8x37nx4s	254	7	NMR	NMR	NNP
cord-310192-8x37nx4s	254	8	structure	structure	NN
cord-310192-8x37nx4s	254	9	of	of	IN
cord-310192-8x37nx4s	254	10	a	a	DT
cord-310192-8x37nx4s	254	11	30	30	CD
cord-310192-8x37nx4s	254	12	kDa	kDa	NNP
cord-310192-8x37nx4s	254	13	GAAA	GAAA	NNP
cord-310192-8x37nx4s	254	14	tetraloop	tetraloop	NNP
cord-310192-8x37nx4s	254	15	-	-	HYPH
cord-310192-8x37nx4s	254	16	receptor	receptor	NN
cord-310192-8x37nx4s	254	17	complex	complex	JJ
cord-310192-8x37nx4s	254	18	Accurate	accurate	JJ
cord-310192-8x37nx4s	254	19	SHAPE	shape	NN
cord-310192-8x37nx4s	254	20	-	-	HYPH
cord-310192-8x37nx4s	254	21	directed	direct	VBN
cord-310192-8x37nx4s	254	22	RNA	RNA	NNP
cord-310192-8x37nx4s	254	23	structure	structure	NN
cord-310192-8x37nx4s	254	24	determination	determination	NN
cord-310192-8x37nx4s	254	25	Functional	functional	JJ
cord-310192-8x37nx4s	254	26	complexity	complexity	NN
cord-310192-8x37nx4s	254	27	and	and	CC
cord-310192-8x37nx4s	254	28	regulation	regulation	NN
cord-310192-8x37nx4s	254	29	through	through	IN
cord-310192-8x37nx4s	254	30	RNA	RNA	NNP
cord-310192-8x37nx4s	254	31	dynamics	dynamic	NNS
cord-310192-8x37nx4s	254	32	Visualizing	visualize	VBG
cord-310192-8x37nx4s	254	33	transient	transient	JJ
cord-310192-8x37nx4s	254	34	low	low	RB
cord-310192-8x37nx4s	254	35	-	-	HYPH
cord-310192-8x37nx4s	254	36	populated	populated	JJ
cord-310192-8x37nx4s	254	37	structures	structure	NNS
cord-310192-8x37nx4s	254	38	of	of	IN
cord-310192-8x37nx4s	254	39	RNA	RNA	NNP
cord-310192-8x37nx4s	254	40	Direct	direct	JJ
cord-310192-8x37nx4s	254	41	observation	observation	NN
cord-310192-8x37nx4s	254	42	of	of	IN
cord-310192-8x37nx4s	254	43	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	254	44	bonds	bond	NNS
cord-310192-8x37nx4s	254	45	in	in	IN
cord-310192-8x37nx4s	254	46	nucleic	nucleic	JJ
cord-310192-8x37nx4s	254	47	acid	acid	NN
cord-310192-8x37nx4s	254	48	base	base	NN
cord-310192-8x37nx4s	254	49	pairs	pair	NNS
cord-310192-8x37nx4s	254	50	by	by	IN
cord-310192-8x37nx4s	254	51	internucleotide	internucleotide	NNP
cord-310192-8x37nx4s	254	52	(	(	-LRB-
cord-310192-8x37nx4s	254	53	2)J(NN	2)J(NN	NNP
cord-310192-8x37nx4s	254	54	)	)	-RRB-
cord-310192-8x37nx4s	254	55	couplings	coupling	NNS
cord-310192-8x37nx4s	254	56	.	.	.
cord-310192-8x37nx4s	255	1	Journal	Journal	NNP
cord-310192-8x37nx4s	255	2	of	of	IN
cord-310192-8x37nx4s	255	3	the	the	DT
cord-310192-8x37nx4s	255	4	Cryo	Cryo	NNP
cord-310192-8x37nx4s	255	5	-	-	HYPH
cord-310192-8x37nx4s	255	6	EM	EM	NNP
cord-310192-8x37nx4s	255	7	structures	structure	NNS
cord-310192-8x37nx4s	255	8	and	and	CC
cord-310192-8x37nx4s	255	9	dynamics	dynamic	NNS
cord-310192-8x37nx4s	255	10	of	of	IN
cord-310192-8x37nx4s	255	11	substrate	substrate	NN
cord-310192-8x37nx4s	255	12	-	-	HYPH
cord-310192-8x37nx4s	255	13	engaged	engage	VBN
cord-310192-8x37nx4s	255	14	human	human	NN
cord-310192-8x37nx4s	255	15	26S	26S	NNP
cord-310192-8x37nx4s	255	16	proteasome	proteasome	VBD
cord-310192-8x37nx4s	255	17	NMR	NMR	NNP
cord-310192-8x37nx4s	255	18	structure	structure	NN
cord-310192-8x37nx4s	255	19	of	of	IN
cord-310192-8x37nx4s	255	20	the	the	DT
cord-310192-8x37nx4s	255	21	101-nucleotide	101-nucleotide	CD
cord-310192-8x37nx4s	255	22	core	core	NN
cord-310192-8x37nx4s	255	23	encapsidation	encapsidation	NN
cord-310192-8x37nx4s	255	24	signal	signal	NN
cord-310192-8x37nx4s	255	25	of	of	IN
cord-310192-8x37nx4s	255	26	the	the	DT
cord-310192-8x37nx4s	255	27	Moloney	Moloney	NNP
cord-310192-8x37nx4s	255	28	murine	murine	JJ
cord-310192-8x37nx4s	255	29	leukemia	leukemia	NN
cord-310192-8x37nx4s	255	30	virus	virus	NN
cord-310192-8x37nx4s	255	31	Structural	structural	JJ
cord-310192-8x37nx4s	255	32	basis	basis	NN
cord-310192-8x37nx4s	255	33	for	for	IN
cord-310192-8x37nx4s	255	34	packaging	package	VBG
cord-310192-8x37nx4s	255	35	the	the	DT
cord-310192-8x37nx4s	255	36	dimeric	dimeric	JJ
cord-310192-8x37nx4s	255	37	genome	genome	NN
cord-310192-8x37nx4s	255	38	of	of	IN
cord-310192-8x37nx4s	255	39	Moloney	Moloney	NNP
cord-310192-8x37nx4s	255	40	murine	murine	JJ
cord-310192-8x37nx4s	255	41	leukaemia	leukaemia	NN
cord-310192-8x37nx4s	255	42	virus	virus	NN
cord-310192-8x37nx4s	255	43	A	a	DT
cord-310192-8x37nx4s	255	44	fast	fast	JJ
cord-310192-8x37nx4s	255	45	,	,	,
cord-310192-8x37nx4s	255	46	efficient	efficient	JJ
cord-310192-8x37nx4s	255	47	and	and	CC
cord-310192-8x37nx4s	255	48	sequence	sequence	NN
cord-310192-8x37nx4s	255	49	-	-	HYPH
cord-310192-8x37nx4s	255	50	independent	independent	JJ
cord-310192-8x37nx4s	255	51	method	method	NN
cord-310192-8x37nx4s	255	52	for	for	IN
cord-310192-8x37nx4s	255	53	flexible	flexible	JJ
cord-310192-8x37nx4s	255	54	multiple	multiple	JJ
cord-310192-8x37nx4s	255	55	segmental	segmental	JJ
cord-310192-8x37nx4s	255	56	isotope	isotope	NN
cord-310192-8x37nx4s	255	57	labeling	labeling	NN
cord-310192-8x37nx4s	255	58	of	of	IN
cord-310192-8x37nx4s	255	59	RNA	RNA	NNP
cord-310192-8x37nx4s	255	60	using	use	VBG
cord-310192-8x37nx4s	255	61	ribozyme	ribozyme	NNS
cord-310192-8x37nx4s	255	62	and	and	CC
cord-310192-8x37nx4s	255	63	RNase	rnase	NN
cord-310192-8x37nx4s	255	64	H	H	NNP
cord-310192-8x37nx4s	255	65	cleavage	cleavage	NN
cord-310192-8x37nx4s	255	66	Probing	probe	VBG
cord-310192-8x37nx4s	255	67	the	the	DT
cord-310192-8x37nx4s	255	68	structure	structure	NN
cord-310192-8x37nx4s	255	69	of	of	IN
cord-310192-8x37nx4s	255	70	RNAs	rna	NNS
cord-310192-8x37nx4s	255	71	in	in	IN
cord-310192-8x37nx4s	255	72	solution	solution	NN
cord-310192-8x37nx4s	255	73	Non	Non	NNP
cord-310192-8x37nx4s	255	74	-	-	JJ
cord-310192-8x37nx4s	255	75	coding	code	VBG
cord-310192-8x37nx4s	255	76	RNAs	rna	NNS
cord-310192-8x37nx4s	255	77	in	in	IN
cord-310192-8x37nx4s	255	78	human	human	JJ
cord-310192-8x37nx4s	255	79	disease	disease	NN
cord-310192-8x37nx4s	255	80	Longitudinal	longitudinal	JJ
cord-310192-8x37nx4s	255	81	-	-	HYPH
cord-310192-8x37nx4s	255	82	relaxation	relaxation	NN
cord-310192-8x37nx4s	255	83	-	-	HYPH
cord-310192-8x37nx4s	255	84	enhanced	enhance	VBN
cord-310192-8x37nx4s	255	85	NMR	NMR	NNP
cord-310192-8x37nx4s	255	86	experiments	experiment	NNS
cord-310192-8x37nx4s	255	87	for	for	IN
cord-310192-8x37nx4s	255	88	the	the	DT
cord-310192-8x37nx4s	255	89	study	study	NN
cord-310192-8x37nx4s	255	90	of	of	IN
cord-310192-8x37nx4s	255	91	nucleic	nucleic	JJ
cord-310192-8x37nx4s	255	92	acids	acid	NNS
cord-310192-8x37nx4s	255	93	in	in	IN
cord-310192-8x37nx4s	255	94	solution	solution	NN
cord-310192-8x37nx4s	255	95	NMR	NMR	NNP
cord-310192-8x37nx4s	255	96	studies	study	NNS
cord-310192-8x37nx4s	255	97	of	of	IN
cord-310192-8x37nx4s	255	98	A.C	A.C	NNP
cord-310192-8x37nx4s	255	99	mismatches	mismatch	NNS
cord-310192-8x37nx4s	255	100	in	in	IN
cord-310192-8x37nx4s	255	101	DNA	dna	NN
cord-310192-8x37nx4s	255	102	dodecanucleotides	dodecanucleotide	NNS
cord-310192-8x37nx4s	255	103	at	at	IN
cord-310192-8x37nx4s	255	104	acidic	acidic	JJ
cord-310192-8x37nx4s	255	105	pH.	ph.	NN
cord-310192-8x37nx4s	255	106	Wobble	Wobble	NNP
cord-310192-8x37nx4s	255	107	A(anti).C(anti	A(anti).C(anti	NNP
cord-310192-8x37nx4s	255	108	)	)	-RRB-
cord-310192-8x37nx4s	256	1	pair	pair	NN
cord-310192-8x37nx4s	256	2	formation	formation	NN
cord-310192-8x37nx4s	256	3	Visualizing	visualize	VBG
cord-310192-8x37nx4s	256	4	the	the	DT
cord-310192-8x37nx4s	256	5	global	global	JJ
cord-310192-8x37nx4s	256	6	secondary	secondary	JJ
cord-310192-8x37nx4s	256	7	structure	structure	NN
cord-310192-8x37nx4s	256	8	of	of	IN
cord-310192-8x37nx4s	256	9	a	a	DT
cord-310192-8x37nx4s	256	10	viral	viral	JJ
cord-310192-8x37nx4s	256	11	RNA	RNA	NNP
cord-310192-8x37nx4s	256	12	genome	genome	NN
cord-310192-8x37nx4s	256	13	with	with	IN
cord-310192-8x37nx4s	256	14	cryo	cryo	NN
cord-310192-8x37nx4s	256	15	-	-	HYPH
cord-310192-8x37nx4s	256	16	electron	electron	NN
cord-310192-8x37nx4s	256	17	microscopy	microscopy	NN
cord-310192-8x37nx4s	257	1	Strong	strong	JJ
cord-310192-8x37nx4s	257	2	correlation	correlation	NN
cord-310192-8x37nx4s	257	3	between	between	IN
cord-310192-8x37nx4s	257	4	SHAPE	shape	NN
cord-310192-8x37nx4s	257	5	chemistry	chemistry	NN
cord-310192-8x37nx4s	257	6	and	and	CC
cord-310192-8x37nx4s	257	7	the	the	DT
cord-310192-8x37nx4s	257	8	generalized	generalized	JJ
cord-310192-8x37nx4s	257	9	NMR	NMR	NNP
cord-310192-8x37nx4s	257	10	order	order	NN
cord-310192-8x37nx4s	257	11	parameter	parameter	NN
cord-310192-8x37nx4s	257	12	(	(	-LRB-
cord-310192-8x37nx4s	257	13	S2	S2	NNP
cord-310192-8x37nx4s	257	14	)	)	-RRB-
cord-310192-8x37nx4s	257	15	in	in	IN
cord-310192-8x37nx4s	257	16	RNA	RNA	NNP
cord-310192-8x37nx4s	257	17	Conjoined	conjoined	JJ
cord-310192-8x37nx4s	257	18	use	use	NN
cord-310192-8x37nx4s	257	19	of	of	IN
cord-310192-8x37nx4s	257	20	EM	EM	NNP
cord-310192-8x37nx4s	257	21	and	and	CC
cord-310192-8x37nx4s	257	22	NMR	NMR	NNP
cord-310192-8x37nx4s	257	23	in	in	IN
cord-310192-8x37nx4s	257	24	RNA	RNA	NNP
cord-310192-8x37nx4s	257	25	structure	structure	NN
cord-310192-8x37nx4s	257	26	refinement	refinement	NN
cord-310192-8x37nx4s	257	27	Visualizing	visualize	VBG
cord-310192-8x37nx4s	257	28	large	large	JJ
cord-310192-8x37nx4s	257	29	RNA	RNA	NNP
cord-310192-8x37nx4s	257	30	molecules	molecule	NNS
cord-310192-8x37nx4s	257	31	in	in	IN
cord-310192-8x37nx4s	257	32	solution	solution	NN
cord-310192-8x37nx4s	257	33	Solution	Solution	NNP
cord-310192-8x37nx4s	257	34	structure	structure	NN
cord-310192-8x37nx4s	257	35	of	of	IN
cord-310192-8x37nx4s	257	36	tRNAVal	tRNAVal	NNP
cord-310192-8x37nx4s	257	37	from	from	IN
cord-310192-8x37nx4s	257	38	refinement	refinement	NN
cord-310192-8x37nx4s	257	39	of	of	IN
cord-310192-8x37nx4s	257	40	homology	homology	NN
cord-310192-8x37nx4s	257	41	model	model	NN
cord-310192-8x37nx4s	257	42	against	against	IN
cord-310192-8x37nx4s	257	43	residual	residual	JJ
cord-310192-8x37nx4s	257	44	dipolar	dipolar	JJ
cord-310192-8x37nx4s	257	45	coupling	coupling	NN
cord-310192-8x37nx4s	257	46	and	and	CC
cord-310192-8x37nx4s	257	47	SAXS	SAXS	NNP
cord-310192-8x37nx4s	257	48	data	datum	NNS
cord-310192-8x37nx4s	257	49	RNA	RNA	NNP
cord-310192-8x37nx4s	257	50	-	-	HYPH
cord-310192-8x37nx4s	257	51	RNA	RNA	NNP
cord-310192-8x37nx4s	257	52	interactions	interaction	NNS
cord-310192-8x37nx4s	257	53	in	in	IN
cord-310192-8x37nx4s	257	54	gene	gene	NN
cord-310192-8x37nx4s	257	55	regulation	regulation	NN
cord-310192-8x37nx4s	257	56	:	:	:
cord-310192-8x37nx4s	257	57	The	the	DT
cord-310192-8x37nx4s	257	58	coding	code	VBG
cord-310192-8x37nx4s	257	59	and	and	CC
cord-310192-8x37nx4s	257	60	noncoding	noncoding	JJ
cord-310192-8x37nx4s	257	61	players	player	NNS
cord-310192-8x37nx4s	257	62	Insight	Insight	NNP
cord-310192-8x37nx4s	257	63	into	into	IN
cord-310192-8x37nx4s	257	64	the	the	DT
cord-310192-8x37nx4s	257	65	CSA	CSA	NNP
cord-310192-8x37nx4s	257	66	tensors	tensor	NNS
cord-310192-8x37nx4s	257	67	of	of	IN
cord-310192-8x37nx4s	257	68	nucleobase	nucleobase	NNP
cord-310192-8x37nx4s	257	69	carbons	carbon	NNS
cord-310192-8x37nx4s	257	70	in	in	IN
cord-310192-8x37nx4s	257	71	RNA	RNA	NNP
cord-310192-8x37nx4s	257	72	polynucleotides	polynucleotide	NNS
cord-310192-8x37nx4s	257	73	from	from	IN
cord-310192-8x37nx4s	257	74	solution	solution	NN
cord-310192-8x37nx4s	257	75	measurements	measurement	NNS
cord-310192-8x37nx4s	257	76	of	of	IN
cord-310192-8x37nx4s	257	77	residual	residual	JJ
cord-310192-8x37nx4s	257	78	CSA	CSA	NNP
cord-310192-8x37nx4s	257	79	:	:	:
cord-310192-8x37nx4s	258	1	Towards	towards	IN
cord-310192-8x37nx4s	258	2	new	new	JJ
cord-310192-8x37nx4s	258	3	long	long	JJ
cord-310192-8x37nx4s	258	4	-	-	HYPH
cord-310192-8x37nx4s	258	5	range	range	NN
cord-310192-8x37nx4s	258	6	orientational	orientational	JJ
cord-310192-8x37nx4s	258	7	constraints	constraint	NNS
cord-310192-8x37nx4s	258	8	Extending	extend	VBG
cord-310192-8x37nx4s	258	9	the	the	DT
cord-310192-8x37nx4s	258	10	range	range	NN
cord-310192-8x37nx4s	258	11	of	of	IN
cord-310192-8x37nx4s	258	12	microsecond	microsecond	NN
cord-310192-8x37nx4s	258	13	-	-	HYPH
cord-310192-8x37nx4s	258	14	to	to	IN
cord-310192-8x37nx4s	258	15	-	-	HYPH
cord-310192-8x37nx4s	258	16	millisecond	millisecond	NN
cord-310192-8x37nx4s	258	17	chemical	chemical	NN
cord-310192-8x37nx4s	258	18	exchange	exchange	NN
cord-310192-8x37nx4s	258	19	detected	detect	VBN
cord-310192-8x37nx4s	258	20	in	in	IN
cord-310192-8x37nx4s	258	21	labeled	labeled	JJ
cord-310192-8x37nx4s	258	22	and	and	CC
cord-310192-8x37nx4s	258	23	unlabeled	unlabeled	JJ
cord-310192-8x37nx4s	258	24	nucleic	nucleic	JJ
cord-310192-8x37nx4s	258	25	acids	acid	NNS
cord-310192-8x37nx4s	258	26	by	by	IN
cord-310192-8x37nx4s	258	27	selective	selective	JJ
cord-310192-8x37nx4s	258	28	carbon	carbon	NN
cord-310192-8x37nx4s	258	29	R-1	R-1	NNP
cord-310192-8x37nx4s	258	30	rho	rho	NN
cord-310192-8x37nx4s	258	31	NMR	nmr	NN
cord-310192-8x37nx4s	258	32	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	258	33	Pf1	pf1	CD
cord-310192-8x37nx4s	258	34	filamentous	filamentous	JJ
cord-310192-8x37nx4s	258	35	phage	phage	NN
cord-310192-8x37nx4s	258	36	as	as	IN
cord-310192-8x37nx4s	258	37	an	an	DT
cord-310192-8x37nx4s	258	38	alignment	alignment	NN
cord-310192-8x37nx4s	258	39	tool	tool	NN
cord-310192-8x37nx4s	258	40	for	for	IN
cord-310192-8x37nx4s	258	41	generating	generate	VBG
cord-310192-8x37nx4s	258	42	local	local	JJ
cord-310192-8x37nx4s	258	43	and	and	CC
cord-310192-8x37nx4s	258	44	global	global	JJ
cord-310192-8x37nx4s	258	45	structural	structural	JJ
cord-310192-8x37nx4s	258	46	information	information	NN
cord-310192-8x37nx4s	258	47	in	in	IN
cord-310192-8x37nx4s	258	48	nucleic	nucleic	JJ
cord-310192-8x37nx4s	258	49	acids	acid	NNS
cord-310192-8x37nx4s	258	50	Tunable	tunable	JJ
cord-310192-8x37nx4s	258	51	alignment	alignment	NN
cord-310192-8x37nx4s	258	52	of	of	IN
cord-310192-8x37nx4s	258	53	macromolecules	macromolecule	NNS
cord-310192-8x37nx4s	258	54	by	by	IN
cord-310192-8x37nx4s	258	55	filamentous	filamentous	JJ
cord-310192-8x37nx4s	258	56	phage	phage	NN
cord-310192-8x37nx4s	258	57	yields	yield	NNS
cord-310192-8x37nx4s	258	58	dipolar	dipolar	JJ
cord-310192-8x37nx4s	258	59	coupling	coupling	NN
cord-310192-8x37nx4s	258	60	interactions	interaction	NNS
cord-310192-8x37nx4s	258	61	Time	time	NN
cord-310192-8x37nx4s	258	62	-	-	HYPH
cord-310192-8x37nx4s	258	63	resolved	resolve	VBN
cord-310192-8x37nx4s	258	64	hydroxyl	hydroxyl	NN
cord-310192-8x37nx4s	258	65	radical	radical	JJ
cord-310192-8x37nx4s	258	66	footprinting	footprinting	NN
cord-310192-8x37nx4s	258	67	of	of	IN
cord-310192-8x37nx4s	258	68	RNA	RNA	NNP
cord-310192-8x37nx4s	258	69	with	with	IN
cord-310192-8x37nx4s	258	70	X	X	NNS
cord-310192-8x37nx4s	258	71	-	-	NNS
cord-310192-8x37nx4s	258	72	rays	ray	NNS
cord-310192-8x37nx4s	258	73	NMR	NMR	NNP
cord-310192-8x37nx4s	258	74	structural	structural	JJ
cord-310192-8x37nx4s	258	75	profiling	profiling	NN
cord-310192-8x37nx4s	258	76	of	of	IN
cord-310192-8x37nx4s	258	77	transcriptional	transcriptional	JJ
cord-310192-8x37nx4s	258	78	intermediates	intermediate	NNS
cord-310192-8x37nx4s	258	79	reveals	reveal	VBZ
cord-310192-8x37nx4s	258	80	riboswitch	riboswitch	NN
cord-310192-8x37nx4s	258	81	regulation	regulation	NN
cord-310192-8x37nx4s	258	82	by	by	IN
cord-310192-8x37nx4s	258	83	metastable	metastable	JJ
cord-310192-8x37nx4s	258	84	RNA	RNA	NNP
cord-310192-8x37nx4s	258	85	conformations	conformation	NNS
cord-310192-8x37nx4s	258	86	Single	single	JJ
cord-310192-8x37nx4s	258	87	-	-	HYPH
cord-310192-8x37nx4s	258	88	molecule	molecule	NN
cord-310192-8x37nx4s	258	89	correlated	correlate	VBN
cord-310192-8x37nx4s	258	90	chemical	chemical	NN
cord-310192-8x37nx4s	258	91	probing	probing	NN
cord-310192-8x37nx4s	258	92	of	of	IN
cord-310192-8x37nx4s	258	93	RNA	RNA	NNP
cord-310192-8x37nx4s	258	94	An	an	DT
cord-310192-8x37nx4s	258	95	equilibrium	equilibrium	NN
cord-310192-8x37nx4s	258	96	-	-	HYPH
cord-310192-8x37nx4s	258	97	dependent	dependent	JJ
cord-310192-8x37nx4s	258	98	retroviral	retroviral	NN
cord-310192-8x37nx4s	258	99	mRNA	mRNA	NNP
cord-310192-8x37nx4s	258	100	switch	switch	NN
cord-310192-8x37nx4s	258	101	regulates	regulate	VBZ
cord-310192-8x37nx4s	258	102	translational	translational	JJ
cord-310192-8x37nx4s	258	103	recoding	recode	VBG
cord-310192-8x37nx4s	258	104	An	an	DT
cord-310192-8x37nx4s	258	105	efficient	efficient	JJ
cord-310192-8x37nx4s	258	106	and	and	CC
cord-310192-8x37nx4s	258	107	economic	economic	JJ
cord-310192-8x37nx4s	258	108	site	site	NN
cord-310192-8x37nx4s	258	109	-	-	HYPH
cord-310192-8x37nx4s	258	110	specific	specific	JJ
cord-310192-8x37nx4s	258	111	deuteration	deuteration	NN
cord-310192-8x37nx4s	258	112	strategy	strategy	NN
cord-310192-8x37nx4s	258	113	for	for	IN
cord-310192-8x37nx4s	258	114	NMR	NMR	NNP
cord-310192-8x37nx4s	258	115	studies	study	NNS
cord-310192-8x37nx4s	258	116	of	of	IN
cord-310192-8x37nx4s	258	117	homologous	homologous	JJ
cord-310192-8x37nx4s	258	118	oligonucleotide	oligonucleotide	IN
cord-310192-8x37nx4s	258	119	repeat	repeat	NN
cord-310192-8x37nx4s	258	120	sequences	sequence	NNS
cord-310192-8x37nx4s	259	1	An	an	DT
cord-310192-8x37nx4s	259	2	accurately	accurately	RB
cord-310192-8x37nx4s	259	3	preorganized	preorganize	VBN
cord-310192-8x37nx4s	259	4	IRES	IRES	NNP
cord-310192-8x37nx4s	259	5	RNA	RNA	NNP
cord-310192-8x37nx4s	259	6	structure	structure	NN
cord-310192-8x37nx4s	259	7	enables	enable	VBZ
cord-310192-8x37nx4s	259	8	eIF4	eif4	IN
cord-310192-8x37nx4s	259	9	G	g	NN
cord-310192-8x37nx4s	259	10	capture	capture	NN
cord-310192-8x37nx4s	259	11	for	for	IN
cord-310192-8x37nx4s	259	12	initiation	initiation	NN
cord-310192-8x37nx4s	259	13	of	of	IN
cord-310192-8x37nx4s	259	14	viral	viral	JJ
cord-310192-8x37nx4s	259	15	translation	translation	NN
cord-310192-8x37nx4s	259	16	Solution	Solution	NNP
cord-310192-8x37nx4s	259	17	structure	structure	NN
cord-310192-8x37nx4s	259	18	of	of	IN
cord-310192-8x37nx4s	259	19	the	the	DT
cord-310192-8x37nx4s	259	20	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	259	21	intron	intron	NN
cord-310192-8x37nx4s	259	22	splicing	splicing	NN
cord-310192-8x37nx4s	259	23	silencer	silencer	NN
cord-310192-8x37nx4s	259	24	and	and	CC
cord-310192-8x37nx4s	259	25	its	-PRON-	PRP$
cord-310192-8x37nx4s	259	26	interactions	interaction	NNS
cord-310192-8x37nx4s	259	27	with	with	IN
cord-310192-8x37nx4s	259	28	the	the	DT
cord-310192-8x37nx4s	259	29	UP1	up1	JJ
cord-310192-8x37nx4s	259	30	domain	domain	NN
cord-310192-8x37nx4s	259	31	of	of	IN
cord-310192-8x37nx4s	259	32	heterogeneous	heterogeneous	JJ
cord-310192-8x37nx4s	259	33	nuclear	nuclear	JJ
cord-310192-8x37nx4s	259	34	ribonucleoprotein	ribonucleoprotein	NN
cord-310192-8x37nx4s	259	35	(	(	-LRB-
cord-310192-8x37nx4s	259	36	hnRNP	hnrnp	NN
cord-310192-8x37nx4s	259	37	)	)	-RRB-
cord-310192-8x37nx4s	260	1	A1	A1	NNP
cord-310192-8x37nx4s	260	2	Extensive	extensive	JJ
cord-310192-8x37nx4s	260	3	backbone	backbone	NN
cord-310192-8x37nx4s	260	4	dynamics	dynamic	NNS
cord-310192-8x37nx4s	260	5	in	in	IN
cord-310192-8x37nx4s	260	6	the	the	DT
cord-310192-8x37nx4s	260	7	GCAA	GCAA	NNP
cord-310192-8x37nx4s	260	8	RNA	RNA	NNP
cord-310192-8x37nx4s	260	9	tetraloop	tetraloop	NN
cord-310192-8x37nx4s	260	10	analyzed	analyze	VBD
cord-310192-8x37nx4s	260	11	using	use	VBG
cord-310192-8x37nx4s	260	12	13C	13c	CD
cord-310192-8x37nx4s	260	13	NMR	NMR	NNP
cord-310192-8x37nx4s	260	14	spin	spin	NN
cord-310192-8x37nx4s	260	15	relaxation	relaxation	NN
cord-310192-8x37nx4s	260	16	and	and	CC
cord-310192-8x37nx4s	260	17	specific	specific	JJ
cord-310192-8x37nx4s	260	18	isotope	isotope	NN
cord-310192-8x37nx4s	260	19	labeling	label	VBG
cord-310192-8x37nx4s	260	20	Long	long	JJ
cord-310192-8x37nx4s	260	21	-	-	HYPH
cord-310192-8x37nx4s	260	22	range	range	NN
cord-310192-8x37nx4s	260	23	interactions	interaction	NNS
cord-310192-8x37nx4s	260	24	in	in	IN
cord-310192-8x37nx4s	260	25	riboswitch	riboswitch	NN
cord-310192-8x37nx4s	260	26	control	control	NN
cord-310192-8x37nx4s	260	27	of	of	IN
cord-310192-8x37nx4s	260	28	gene	gene	NN
cord-310192-8x37nx4s	260	29	expression	expression	NN
cord-310192-8x37nx4s	260	30	Structural	structural	JJ
cord-310192-8x37nx4s	260	31	determinants	determinant	NNS
cord-310192-8x37nx4s	260	32	for	for	IN
cord-310192-8x37nx4s	260	33	ligand	ligand	NN
cord-310192-8x37nx4s	260	34	capture	capture	NN
cord-310192-8x37nx4s	260	35	by	by	IN
cord-310192-8x37nx4s	260	36	a	a	DT
cord-310192-8x37nx4s	260	37	class	class	NN
cord-310192-8x37nx4s	260	38	II	ii	NN
cord-310192-8x37nx4s	260	39	preQ1	preq1	NN
cord-310192-8x37nx4s	260	40	riboswitch	riboswitch	NN
cord-310192-8x37nx4s	260	41	De	de	FW
cord-310192-8x37nx4s	260	42	novo	novo	NNP
cord-310192-8x37nx4s	260	43	computational	computational	JJ
cord-310192-8x37nx4s	260	44	RNA	RNA	NNP
cord-310192-8x37nx4s	260	45	modeling	model	VBG
cord-310192-8x37nx4s	260	46	into	into	IN
cord-310192-8x37nx4s	260	47	cryo	cryo	NN
cord-310192-8x37nx4s	260	48	-	-	HYPH
cord-310192-8x37nx4s	260	49	EM	EM	NNP
cord-310192-8x37nx4s	260	50	maps	map	NNS
cord-310192-8x37nx4s	260	51	of	of	IN
cord-310192-8x37nx4s	260	52	large	large	JJ
cord-310192-8x37nx4s	260	53	ribonucleoprotein	ribonucleoprotein	NN
cord-310192-8x37nx4s	260	54	complexes	complex	NNS
cord-310192-8x37nx4s	260	55	RNA	RNA	NNP
cord-310192-8x37nx4s	260	56	structure	structure	NN
cord-310192-8x37nx4s	260	57	.	.	.
cord-310192-8x37nx4s	261	1	Structure	structure	NN
cord-310192-8x37nx4s	261	2	of	of	IN
cord-310192-8x37nx4s	261	3	the	the	DT
cord-310192-8x37nx4s	261	4	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	261	5	RNA	RNA	NNP
cord-310192-8x37nx4s	261	6	packaging	packaging	NN
cord-310192-8x37nx4s	261	7	signal	signal	NN
cord-310192-8x37nx4s	261	8	NMR	NMR	NNP
cord-310192-8x37nx4s	261	9	detection	detection	NN
cord-310192-8x37nx4s	261	10	of	of	IN
cord-310192-8x37nx4s	261	11	intermolecular	intermolecular	JJ
cord-310192-8x37nx4s	261	12	interaction	interaction	NN
cord-310192-8x37nx4s	261	13	sites	site	NNS
cord-310192-8x37nx4s	261	14	in	in	IN
cord-310192-8x37nx4s	261	15	the	the	DT
cord-310192-8x37nx4s	261	16	dimeric	dimeric	JJ
cord-310192-8x37nx4s	261	17	5	5	CD
cord-310192-8x37nx4s	261	18	0	0	CD
cord-310192-8x37nx4s	261	19	-leader	-leader	:
cord-310192-8x37nx4s	261	20	of	of	IN
cord-310192-8x37nx4s	261	21	the	the	DT
cord-310192-8x37nx4s	261	22	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	261	23	genome	genome	NN
cord-310192-8x37nx4s	261	24	NMR	NMR	NNP
cord-310192-8x37nx4s	261	25	study	study	NN
cord-310192-8x37nx4s	261	26	of	of	IN
cord-310192-8x37nx4s	261	27	100	100	CD
cord-310192-8x37nx4s	261	28	kDa	kDa	NNP
cord-310192-8x37nx4s	261	29	HCV	HCV	NNP
cord-310192-8x37nx4s	261	30	IRES	IRES	NNP
cord-310192-8x37nx4s	261	31	RNA	RNA	NNP
cord-310192-8x37nx4s	261	32	using	use	VBG
cord-310192-8x37nx4s	261	33	segmental	segmental	JJ
cord-310192-8x37nx4s	261	34	isotope	isotope	NN
cord-310192-8x37nx4s	261	35	labeling	labeling	NN
cord-310192-8x37nx4s	261	36	Structure	structure	NN
cord-310192-8x37nx4s	261	37	and	and	CC
cord-310192-8x37nx4s	261	38	sequence	sequence	NN
cord-310192-8x37nx4s	261	39	elements	element	NNS
cord-310192-8x37nx4s	261	40	of	of	IN
cord-310192-8x37nx4s	261	41	the	the	DT
cord-310192-8x37nx4s	261	42	CR4/5	CR4/5	NNP
cord-310192-8x37nx4s	261	43	domain	domain	NN
cord-310192-8x37nx4s	261	44	of	of	IN
cord-310192-8x37nx4s	261	45	medaka	medaka	NNP
cord-310192-8x37nx4s	261	46	telomerase	telomerase	NN
cord-310192-8x37nx4s	261	47	RNA	RNA	NNP
cord-310192-8x37nx4s	261	48	important	important	JJ
cord-310192-8x37nx4s	261	49	for	for	IN
cord-310192-8x37nx4s	261	50	telomerase	telomerase	NN
cord-310192-8x37nx4s	261	51	function	function	NN
cord-310192-8x37nx4s	261	52	Probing	probe	VBG
cord-310192-8x37nx4s	261	53	RNA	RNA	NNP
cord-310192-8x37nx4s	261	54	dynamics	dynamic	NNS
cord-310192-8x37nx4s	261	55	via	via	IN
cord-310192-8x37nx4s	261	56	longitudinal	longitudinal	JJ
cord-310192-8x37nx4s	261	57	exchange	exchange	NN
cord-310192-8x37nx4s	261	58	and	and	CC
cord-310192-8x37nx4s	261	59	CPMG	CPMG	NNP
cord-310192-8x37nx4s	261	60	relaxation	relaxation	NN
cord-310192-8x37nx4s	261	61	dispersion	dispersion	NN
cord-310192-8x37nx4s	261	62	NMR	nmr	NN
cord-310192-8x37nx4s	261	63	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	261	64	using	use	VBG
cord-310192-8x37nx4s	261	65	a	a	DT
cord-310192-8x37nx4s	261	66	sensitive	sensitive	JJ
cord-310192-8x37nx4s	261	67	13	13	CD
cord-310192-8x37nx4s	261	68	C	c	NN
cord-310192-8x37nx4s	261	69	-	-	HYPH
cord-310192-8x37nx4s	261	70	methyl	methyl	NN
cord-310192-8x37nx4s	261	71	label	label	NN
cord-310192-8x37nx4s	261	72	Structures	structure	NNS
cord-310192-8x37nx4s	261	73	of	of	IN
cord-310192-8x37nx4s	261	74	two	two	CD
cord-310192-8x37nx4s	261	75	aptamers	aptamer	NNS
cord-310192-8x37nx4s	261	76	with	with	IN
cord-310192-8x37nx4s	261	77	differing	differ	VBG
cord-310192-8x37nx4s	261	78	ligand	ligand	NN
cord-310192-8x37nx4s	261	79	specificity	specificity	NN
cord-310192-8x37nx4s	261	80	reveal	reveal	VBP
cord-310192-8x37nx4s	261	81	ruggedness	ruggedness	NN
cord-310192-8x37nx4s	261	82	in	in	IN
cord-310192-8x37nx4s	261	83	the	the	DT
cord-310192-8x37nx4s	261	84	functional	functional	JJ
cord-310192-8x37nx4s	261	85	landscape	landscape	NN
cord-310192-8x37nx4s	261	86	of	of	IN
cord-310192-8x37nx4s	261	87	RNA	RNA	NNP
cord-310192-8x37nx4s	261	88	.	.	.
cord-310192-8x37nx4s	262	1	eLife	eLife	NNP
cord-310192-8x37nx4s	262	2	Biochemistry	Biochemistry	NNP
cord-310192-8x37nx4s	262	3	.	.	.
cord-310192-8x37nx4s	263	1	The	the	DT
cord-310192-8x37nx4s	263	2	resolution	resolution	NN
cord-310192-8x37nx4s	263	3	revolution	revolution	NN
cord-310192-8x37nx4s	263	4	Cryo	Cryo	NNP
cord-310192-8x37nx4s	263	5	-	-	HYPH
cord-310192-8x37nx4s	263	6	EM	EM	NNP
cord-310192-8x37nx4s	263	7	enters	enter	VBZ
cord-310192-8x37nx4s	263	8	a	a	DT
cord-310192-8x37nx4s	263	9	new	new	JJ
cord-310192-8x37nx4s	263	10	era	era	NN
cord-310192-8x37nx4s	263	11	.	.	.
cord-310192-8x37nx4s	264	1	eLife	eLife	NNP
cord-310192-8x37nx4s	264	2	,	,	,
cord-310192-8x37nx4s	264	3	3	3	CD
cord-310192-8x37nx4s	264	4	,	,	,
cord-310192-8x37nx4s	264	5	e03678	e03678	JJ
cord-310192-8x37nx4s	264	6	NMR	NMR	NNP
cord-310192-8x37nx4s	264	7	probing	probe	VBG
cord-310192-8x37nx4s	264	8	of	of	IN
cord-310192-8x37nx4s	264	9	invisible	invisible	JJ
cord-310192-8x37nx4s	264	10	excited	excited	JJ
cord-310192-8x37nx4s	264	11	states	state	NNS
cord-310192-8x37nx4s	264	12	using	use	VBG
cord-310192-8x37nx4s	264	13	selectively	selectively	RB
cord-310192-8x37nx4s	264	14	labeled	label	VBN
cord-310192-8x37nx4s	264	15	RNAs	rna	NNS
cord-310192-8x37nx4s	265	1	Imino	Imino	NNP
cord-310192-8x37nx4s	265	2	proton	proton	NN
cord-310192-8x37nx4s	265	3	exchange	exchange	NN
cord-310192-8x37nx4s	265	4	rates	rate	NNS
cord-310192-8x37nx4s	265	5	imply	imply	VBP
cord-310192-8x37nx4s	265	6	an	an	DT
cord-310192-8x37nx4s	265	7	induced	induce	VBN
cord-310192-8x37nx4s	265	8	-	-	HYPH
cord-310192-8x37nx4s	265	9	fit	fit	JJ
cord-310192-8x37nx4s	265	10	binding	binding	NN
cord-310192-8x37nx4s	265	11	mechanism	mechanism	NN
cord-310192-8x37nx4s	265	12	for	for	IN
cord-310192-8x37nx4s	265	13	the	the	DT
cord-310192-8x37nx4s	265	14	VEGF165-targeting	VEGF165-targeting	NNP
cord-310192-8x37nx4s	265	15	aptamer	aptamer	JJ
cord-310192-8x37nx4s	265	16	Epigenetic	epigenetic	JJ
cord-310192-8x37nx4s	265	17	regulation	regulation	NN
cord-310192-8x37nx4s	265	18	by	by	IN
cord-310192-8x37nx4s	265	19	long	long	JJ
cord-310192-8x37nx4s	265	20	noncoding	noncoding	JJ
cord-310192-8x37nx4s	265	21	RNAs	rna	NNS
cord-310192-8x37nx4s	266	1	Structural	structural	JJ
cord-310192-8x37nx4s	266	2	analysis	analysis	NN
cord-310192-8x37nx4s	266	3	of	of	IN
cord-310192-8x37nx4s	266	4	a	a	DT
cord-310192-8x37nx4s	266	5	class	class	NN
cord-310192-8x37nx4s	266	6	III	iii	NN
cord-310192-8x37nx4s	266	7	preQ1	preq1	NN
cord-310192-8x37nx4s	266	8	riboswitch	riboswitch	NN
cord-310192-8x37nx4s	266	9	reveals	reveal	VBZ
cord-310192-8x37nx4s	266	10	an	an	DT
cord-310192-8x37nx4s	266	11	aptamer	aptamer	JJ
cord-310192-8x37nx4s	266	12	distant	distant	JJ
cord-310192-8x37nx4s	266	13	from	from	IN
cord-310192-8x37nx4s	266	14	a	a	DT
cord-310192-8x37nx4s	266	15	ribosome	ribosome	NN
cord-310192-8x37nx4s	266	16	-	-	HYPH
cord-310192-8x37nx4s	266	17	binding	bind	VBG
cord-310192-8x37nx4s	266	18	site	site	NN
cord-310192-8x37nx4s	266	19	regulated	regulate	VBN
cord-310192-8x37nx4s	266	20	by	by	IN
cord-310192-8x37nx4s	266	21	fast	fast	JJ
cord-310192-8x37nx4s	266	22	dynamics	dynamic	NNS
cord-310192-8x37nx4s	266	23	Riboswitch	Riboswitch	NNP
cord-310192-8x37nx4s	266	24	structure	structure	NN
cord-310192-8x37nx4s	266	25	in	in	IN
cord-310192-8x37nx4s	266	26	the	the	DT
cord-310192-8x37nx4s	266	27	ligand	ligand	NN
cord-310192-8x37nx4s	266	28	-	-	HYPH
cord-310192-8x37nx4s	266	29	free	free	JJ
cord-310192-8x37nx4s	266	30	state	state	NN
cord-310192-8x37nx4s	266	31	Incorporation	Incorporation	NNP
cord-310192-8x37nx4s	266	32	of	of	IN
cord-310192-8x37nx4s	266	33	isotopic	isotopic	JJ
cord-310192-8x37nx4s	266	34	,	,	,
cord-310192-8x37nx4s	266	35	fluorescent	fluorescent	NN
cord-310192-8x37nx4s	266	36	,	,	,
cord-310192-8x37nx4s	266	37	and	and	CC
cord-310192-8x37nx4s	266	38	heavy	heavy	RB
cord-310192-8x37nx4s	266	39	-	-	HYPH
cord-310192-8x37nx4s	266	40	atommodified	atommodified	JJ
cord-310192-8x37nx4s	266	41	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	266	42	into	into	IN
cord-310192-8x37nx4s	266	43	RNAs	rna	NNS
cord-310192-8x37nx4s	266	44	by	by	IN
cord-310192-8x37nx4s	266	45	position	position	NN
cord-310192-8x37nx4s	266	46	-	-	HYPH
cord-310192-8x37nx4s	266	47	selective	selective	JJ
cord-310192-8x37nx4s	266	48	labeling	labeling	NN
cord-310192-8x37nx4s	266	49	of	of	IN
cord-310192-8x37nx4s	266	50	RNA	RNA	NNP
cord-310192-8x37nx4s	266	51	Synthesis	Synthesis	NNP
cord-310192-8x37nx4s	266	52	and	and	CC
cord-310192-8x37nx4s	266	53	applications	application	NNS
cord-310192-8x37nx4s	266	54	of	of	IN
cord-310192-8x37nx4s	266	55	RNAs	rna	NNS
cord-310192-8x37nx4s	266	56	with	with	IN
cord-310192-8x37nx4s	266	57	positionselective	positionselective	JJ
cord-310192-8x37nx4s	266	58	labelling	labelling	NN
cord-310192-8x37nx4s	266	59	and	and	CC
cord-310192-8x37nx4s	266	60	mosaic	mosaic	JJ
cord-310192-8x37nx4s	266	61	composition	composition	NN
cord-310192-8x37nx4s	266	62	Applications	application	NNS
cord-310192-8x37nx4s	266	63	of	of	IN
cord-310192-8x37nx4s	266	64	PLOR	PLOR	NNP
cord-310192-8x37nx4s	266	65	in	in	IN
cord-310192-8x37nx4s	266	66	labeling	label	VBG
cord-310192-8x37nx4s	266	67	large	large	JJ
cord-310192-8x37nx4s	266	68	RNAs	rna	NNS
cord-310192-8x37nx4s	266	69	at	at	IN
cord-310192-8x37nx4s	266	70	specific	specific	JJ
cord-310192-8x37nx4s	266	71	sites	site	NNS
cord-310192-8x37nx4s	266	72	Chemo	chemo	NN
cord-310192-8x37nx4s	266	73	-	-	HYPH
cord-310192-8x37nx4s	266	74	enzymatic	enzymatic	JJ
cord-310192-8x37nx4s	266	75	synthesis	synthesis	NN
cord-310192-8x37nx4s	266	76	of	of	IN
cord-310192-8x37nx4s	266	77	site	site	NN
cord-310192-8x37nx4s	266	78	-	-	HYPH
cord-310192-8x37nx4s	266	79	specific	specific	JJ
cord-310192-8x37nx4s	266	80	isotopically	isotopically	RB
cord-310192-8x37nx4s	266	81	labeled	label	VBN
cord-310192-8x37nx4s	266	82	nucleotides	nucleotide	NNS
cord-310192-8x37nx4s	266	83	for	for	IN
cord-310192-8x37nx4s	266	84	use	use	NN
cord-310192-8x37nx4s	266	85	in	in	IN
cord-310192-8x37nx4s	266	86	NMR	NMR	NNP
cord-310192-8x37nx4s	266	87	resonance	resonance	NN
cord-310192-8x37nx4s	266	88	assignment	assignment	NN
cord-310192-8x37nx4s	266	89	,	,	,
cord-310192-8x37nx4s	266	90	dynamics	dynamic	NNS
cord-310192-8x37nx4s	266	91	and	and	CC
cord-310192-8x37nx4s	266	92	structural	structural	JJ
cord-310192-8x37nx4s	266	93	characterizations	characterization	NNS
cord-310192-8x37nx4s	266	94	NMR	NMR	NNP
cord-310192-8x37nx4s	266	95	detection	detection	NN
cord-310192-8x37nx4s	266	96	of	of	IN
cord-310192-8x37nx4s	266	97	structures	structure	NNS
cord-310192-8x37nx4s	266	98	in	in	IN
cord-310192-8x37nx4s	266	99	the	the	DT
cord-310192-8x37nx4s	266	100	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	266	101	5	5	CD
cord-310192-8x37nx4s	266	102	0	0	CD
cord-310192-8x37nx4s	266	103	-leader	-leader	SYM
cord-310192-8x37nx4s	266	104	RNA	RNA	NNP
cord-310192-8x37nx4s	266	105	that	that	WDT
cord-310192-8x37nx4s	266	106	regulate	regulate	VBP
cord-310192-8x37nx4s	266	107	genome	genome	NN
cord-310192-8x37nx4s	266	108	packaging	packaging	NN
cord-310192-8x37nx4s	266	109	Isotope	isotope	NN
cord-310192-8x37nx4s	266	110	labeling	labeling	NN
cord-310192-8x37nx4s	266	111	strategies	strategy	NNS
cord-310192-8x37nx4s	266	112	for	for	IN
cord-310192-8x37nx4s	266	113	NMR	NMR	NNP
cord-310192-8x37nx4s	266	114	studies	study	NNS
cord-310192-8x37nx4s	266	115	of	of	IN
cord-310192-8x37nx4s	266	116	RNA	RNA	NNP
cord-310192-8x37nx4s	266	117	Structure	Structure	NNP
cord-310192-8x37nx4s	266	118	of	of	IN
cord-310192-8x37nx4s	266	119	HCV	HCV	NNP
cord-310192-8x37nx4s	266	120	IRES	IRES	NNP
cord-310192-8x37nx4s	266	121	domain	domain	NN
cord-310192-8x37nx4s	266	122	II	ii	CD
cord-310192-8x37nx4s	266	123	determined	determine	VBN
cord-310192-8x37nx4s	266	124	by	by	IN
cord-310192-8x37nx4s	266	125	NMR	NMR	NNP
cord-310192-8x37nx4s	266	126	Structure	Structure	NNP
cord-310192-8x37nx4s	266	127	determination	determination	NN
cord-310192-8x37nx4s	266	128	of	of	IN
cord-310192-8x37nx4s	266	129	large	large	JJ
cord-310192-8x37nx4s	266	130	biological	biological	JJ
cord-310192-8x37nx4s	266	131	RNAs	RNAs	NNPS
cord-310192-8x37nx4s	266	132	Measurement	Measurement	NNP
cord-310192-8x37nx4s	266	133	of	of	IN
cord-310192-8x37nx4s	266	134	carbonyl	carbonyl	NN
cord-310192-8x37nx4s	266	135	chemical	chemical	NN
cord-310192-8x37nx4s	266	136	shifts	shift	NNS
cord-310192-8x37nx4s	266	137	of	of	IN
cord-310192-8x37nx4s	266	138	excited	excited	JJ
cord-310192-8x37nx4s	266	139	protein	protein	NN
cord-310192-8x37nx4s	266	140	states	state	NNS
cord-310192-8x37nx4s	266	141	by	by	IN
cord-310192-8x37nx4s	266	142	relaxation	relaxation	NN
cord-310192-8x37nx4s	266	143	dispersion	dispersion	NN
cord-310192-8x37nx4s	266	144	NMR	nmr	NN
cord-310192-8x37nx4s	266	145	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	266	146	:	:	:
cord-310192-8x37nx4s	266	147	Comparison	comparison	NN
cord-310192-8x37nx4s	266	148	between	between	IN
cord-310192-8x37nx4s	266	149	uniformly	uniformly	RB
cord-310192-8x37nx4s	266	150	and	and	CC
cord-310192-8x37nx4s	266	151	selectively	selectively	RB
cord-310192-8x37nx4s	266	152	13	13	CD
cord-310192-8x37nx4s	266	153	C	c	NN
cord-310192-8x37nx4s	266	154	labeled	label	VBN
cord-310192-8x37nx4s	266	155	samples	sample	NNS
cord-310192-8x37nx4s	267	1	Accurate	accurate	JJ
cord-310192-8x37nx4s	267	2	measurement	measurement	NN
cord-310192-8x37nx4s	267	3	of	of	IN
cord-310192-8x37nx4s	267	4	residual	residual	JJ
cord-310192-8x37nx4s	267	5	dipolar	dipolar	JJ
cord-310192-8x37nx4s	267	6	couplings	coupling	NNS
cord-310192-8x37nx4s	267	7	in	in	IN
cord-310192-8x37nx4s	267	8	large	large	JJ
cord-310192-8x37nx4s	267	9	RNAs	rna	NNS
cord-310192-8x37nx4s	267	10	by	by	IN
cord-310192-8x37nx4s	267	11	variable	variable	JJ
cord-310192-8x37nx4s	267	12	flip	flip	NN
cord-310192-8x37nx4s	267	13	angle	angle	NN
cord-310192-8x37nx4s	267	14	NMR	NMR	NNP
cord-310192-8x37nx4s	267	15	Visualizing	Visualizing	NNP
cord-310192-8x37nx4s	267	16	group	group	NN
cord-310192-8x37nx4s	267	17	II	II	NNP
cord-310192-8x37nx4s	267	18	intron	intron	NN
cord-310192-8x37nx4s	267	19	catalysis	catalysis	NN
cord-310192-8x37nx4s	267	20	through	through	IN
cord-310192-8x37nx4s	267	21	the	the	DT
cord-310192-8x37nx4s	267	22	stages	stage	NNS
cord-310192-8x37nx4s	267	23	of	of	IN
cord-310192-8x37nx4s	267	24	splicing	splice	VBG
cord-310192-8x37nx4s	267	25	An	an	DT
cord-310192-8x37nx4s	267	26	introduction	introduction	NN
cord-310192-8x37nx4s	267	27	to	to	IN
cord-310192-8x37nx4s	267	28	biological	biological	JJ
cord-310192-8x37nx4s	267	29	NMR	NMR	NNP
cord-310192-8x37nx4s	267	30	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	267	31	RNA	RNA	NNP
cord-310192-8x37nx4s	267	32	structure	structure	NN
cord-310192-8x37nx4s	267	33	analysis	analysis	NN
cord-310192-8x37nx4s	267	34	at	at	IN
cord-310192-8x37nx4s	267	35	single	single	JJ
cord-310192-8x37nx4s	267	36	nucleotide	nucleotide	JJ
cord-310192-8x37nx4s	267	37	resolution	resolution	NN
cord-310192-8x37nx4s	267	38	by	by	IN
cord-310192-8x37nx4s	267	39	selective	selective	JJ
cord-310192-8x37nx4s	267	40	2	2	CD
cord-310192-8x37nx4s	267	41	0	0	CD
cord-310192-8x37nx4s	267	42	-hydroxyl	-hydroxyl	CD
cord-310192-8x37nx4s	267	43	acylation	acylation	NN
cord-310192-8x37nx4s	267	44	and	and	CC
cord-310192-8x37nx4s	267	45	primer	primer	NN
cord-310192-8x37nx4s	267	46	extension	extension	NN
cord-310192-8x37nx4s	267	47	(	(	-LRB-
cord-310192-8x37nx4s	267	48	SHAPE	shape	NN
cord-310192-8x37nx4s	267	49	)	)	-RRB-
cord-310192-8x37nx4s	268	1	Speciation	speciation	NN
cord-310192-8x37nx4s	268	2	of	of	IN
cord-310192-8x37nx4s	268	3	a	a	DT
cord-310192-8x37nx4s	268	4	group	group	NN
cord-310192-8x37nx4s	268	5	I	-PRON-	PRP
cord-310192-8x37nx4s	268	6	intron	intron	VBP
cord-310192-8x37nx4s	268	7	into	into	IN
cord-310192-8x37nx4s	268	8	a	a	DT
cord-310192-8x37nx4s	268	9	lariat	lariat	NN
cord-310192-8x37nx4s	268	10	capping	cap	VBG
cord-310192-8x37nx4s	268	11	ribozyme	ribozyme	NNS
cord-310192-8x37nx4s	269	1	A	a	DT
cord-310192-8x37nx4s	269	2	structure	structure	NN
cord-310192-8x37nx4s	269	3	-	-	HYPH
cord-310192-8x37nx4s	269	4	based	base	VBN
cord-310192-8x37nx4s	269	5	mechanism	mechanism	NN
cord-310192-8x37nx4s	269	6	for	for	IN
cord-310192-8x37nx4s	269	7	tRNA	tRNA	NNP
cord-310192-8x37nx4s	269	8	and	and	CC
cord-310192-8x37nx4s	269	9	retroviral	retroviral	NN
cord-310192-8x37nx4s	269	10	RNA	RNA	NNP
cord-310192-8x37nx4s	269	11	remodelling	remodelling	NN
cord-310192-8x37nx4s	269	12	during	during	IN
cord-310192-8x37nx4s	269	13	primer	primer	NN
cord-310192-8x37nx4s	269	14	annealing	anneal	VBG
cord-310192-8x37nx4s	269	15	Structure	Structure	NNP
cord-310192-8x37nx4s	269	16	of	of	IN
cord-310192-8x37nx4s	269	17	a	a	DT
cord-310192-8x37nx4s	269	18	conserved	conserved	JJ
cord-310192-8x37nx4s	269	19	retroviral	retroviral	NN
cord-310192-8x37nx4s	269	20	RNA	RNA	NNP
cord-310192-8x37nx4s	269	21	packaging	packaging	NN
cord-310192-8x37nx4s	269	22	element	element	NN
cord-310192-8x37nx4s	269	23	by	by	IN
cord-310192-8x37nx4s	269	24	NMR	NMR	NNP
cord-310192-8x37nx4s	269	25	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	269	26	and	and	CC
cord-310192-8x37nx4s	269	27	cryo	cryo	NN
cord-310192-8x37nx4s	269	28	-	-	HYPH
cord-310192-8x37nx4s	269	29	electron	electron	NN
cord-310192-8x37nx4s	269	30	tomography	tomography	NN
cord-310192-8x37nx4s	269	31	Cryo	Cryo	NNP
cord-310192-8x37nx4s	269	32	EM	EM	NNP
cord-310192-8x37nx4s	269	33	structure	structure	NN
cord-310192-8x37nx4s	269	34	of	of	IN
cord-310192-8x37nx4s	269	35	intact	intact	JJ
cord-310192-8x37nx4s	269	36	rotary	rotary	JJ
cord-310192-8x37nx4s	270	1	H(+)-ATPase	H(+)-ATPase	NNP
cord-310192-8x37nx4s	270	2	/	/	SYM
cord-310192-8x37nx4s	270	3	synthase	synthase	NN
cord-310192-8x37nx4s	270	4	from	from	IN
cord-310192-8x37nx4s	270	5	Thermus	Thermus	NNP
cord-310192-8x37nx4s	270	6	thermophilus	thermophilu	VBD
cord-310192-8x37nx4s	270	7	Multiple	multiple	JJ
cord-310192-8x37nx4s	270	8	segmental	segmental	JJ
cord-310192-8x37nx4s	270	9	and	and	CC
cord-310192-8x37nx4s	270	10	selective	selective	JJ
cord-310192-8x37nx4s	270	11	isotope	isotope	NN
cord-310192-8x37nx4s	270	12	labeling	labeling	NN
cord-310192-8x37nx4s	270	13	of	of	IN
cord-310192-8x37nx4s	270	14	large	large	JJ
cord-310192-8x37nx4s	270	15	RNA	RNA	NNP
cord-310192-8x37nx4s	270	16	for	for	IN
cord-310192-8x37nx4s	270	17	NMR	NMR	NNP
cord-310192-8x37nx4s	270	18	structural	structural	JJ
cord-310192-8x37nx4s	270	19	studies	study	NNS
cord-310192-8x37nx4s	270	20	Crystal	Crystal	NNP
cord-310192-8x37nx4s	270	21	structure	structure	NN
cord-310192-8x37nx4s	270	22	of	of	IN
cord-310192-8x37nx4s	270	23	Pistol	Pistol	NNP
cord-310192-8x37nx4s	270	24	,	,	,
cord-310192-8x37nx4s	270	25	a	a	DT
cord-310192-8x37nx4s	270	26	class	class	NN
cord-310192-8x37nx4s	270	27	of	of	IN
cord-310192-8x37nx4s	270	28	self	self	NN
cord-310192-8x37nx4s	270	29	-	-	HYPH
cord-310192-8x37nx4s	270	30	cleaving	cleave	VBG
cord-310192-8x37nx4s	270	31	ribozyme	ribozyme	NNS
cord-310192-8x37nx4s	270	32	RNA	RNA	NNP
cord-310192-8x37nx4s	270	33	dynamics	dynamic	NNS
cord-310192-8x37nx4s	270	34	:	:	:
cord-310192-8x37nx4s	271	1	Perspectives	perspective	NNS
cord-310192-8x37nx4s	271	2	from	from	IN
cord-310192-8x37nx4s	271	3	spin	spin	NN
cord-310192-8x37nx4s	271	4	labels	label	NNS
cord-310192-8x37nx4s	271	5	Preparation	preparation	NN
cord-310192-8x37nx4s	271	6	of	of	IN
cord-310192-8x37nx4s	271	7	13C	13c	CD
cord-310192-8x37nx4s	271	8	and	and	CC
cord-310192-8x37nx4s	271	9	15N	15n	CD
cord-310192-8x37nx4s	271	10	labelled	label	VBN
cord-310192-8x37nx4s	271	11	RNAs	rna	NNS
cord-310192-8x37nx4s	271	12	for	for	IN
cord-310192-8x37nx4s	271	13	heteronuclear	heteronuclear	NNP
cord-310192-8x37nx4s	271	14	multi	multi	JJ
cord-310192-8x37nx4s	271	15	-	-	JJ
cord-310192-8x37nx4s	271	16	dimensional	dimensional	JJ
cord-310192-8x37nx4s	271	17	NMR	NMR	NNP
cord-310192-8x37nx4s	271	18	studies	study	NNS
cord-310192-8x37nx4s	271	19	Cryo	Cryo	NNP
cord-310192-8x37nx4s	271	20	-	-	HYPH
cord-310192-8x37nx4s	271	21	EM	EM	NNP
cord-310192-8x37nx4s	271	22	:	:	:
cord-310192-8x37nx4s	272	1	A	a	DT
cord-310192-8x37nx4s	272	2	unique	unique	JJ
cord-310192-8x37nx4s	272	3	tool	tool	NN
cord-310192-8x37nx4s	272	4	for	for	IN
cord-310192-8x37nx4s	272	5	the	the	DT
cord-310192-8x37nx4s	272	6	visualization	visualization	NN
cord-310192-8x37nx4s	272	7	of	of	IN
cord-310192-8x37nx4s	272	8	macromolecular	macromolecular	JJ
cord-310192-8x37nx4s	272	9	complexity	complexity	NN
cord-310192-8x37nx4s	272	10	Characterization	characterization	NN
cord-310192-8x37nx4s	272	11	of	of	IN
cord-310192-8x37nx4s	272	12	the	the	DT
cord-310192-8x37nx4s	272	13	dynamics	dynamic	NNS
cord-310192-8x37nx4s	272	14	of	of	IN
cord-310192-8x37nx4s	272	15	biomacromolecules	biomacromolecule	NNS
cord-310192-8x37nx4s	272	16	using	use	VBG
cord-310192-8x37nx4s	272	17	rotating	rotate	VBG
cord-310192-8x37nx4s	272	18	-	-	HYPH
cord-310192-8x37nx4s	272	19	frame	frame	NN
cord-310192-8x37nx4s	272	20	spin	spin	NN
cord-310192-8x37nx4s	272	21	relaxation	relaxation	NN
cord-310192-8x37nx4s	272	22	NMR	nmr	NN
cord-310192-8x37nx4s	272	23	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	272	24	Metals	metal	NNS
cord-310192-8x37nx4s	272	25	induce	induce	VBP
cord-310192-8x37nx4s	272	26	transient	transient	JJ
cord-310192-8x37nx4s	272	27	folding	folding	NN
cord-310192-8x37nx4s	272	28	and	and	CC
cord-310192-8x37nx4s	272	29	activation	activation	NN
cord-310192-8x37nx4s	272	30	of	of	IN
cord-310192-8x37nx4s	272	31	the	the	DT
cord-310192-8x37nx4s	272	32	twister	twister	NN
cord-310192-8x37nx4s	272	33	ribozyme	ribozyme	NN
cord-310192-8x37nx4s	272	34	RNA	RNA	NNP
cord-310192-8x37nx4s	272	35	labeling	labeling	NN
cord-310192-8x37nx4s	272	36	,	,	,
cord-310192-8x37nx4s	272	37	conjugation	conjugation	NN
cord-310192-8x37nx4s	272	38	and	and	CC
cord-310192-8x37nx4s	272	39	ligation	ligation	NN
cord-310192-8x37nx4s	272	40	Chemical	chemical	NN
cord-310192-8x37nx4s	272	41	probes	probe	NNS
cord-310192-8x37nx4s	272	42	for	for	IN
cord-310192-8x37nx4s	272	43	higher	high	JJR
cord-310192-8x37nx4s	272	44	-	-	HYPH
cord-310192-8x37nx4s	272	45	order	order	NN
cord-310192-8x37nx4s	272	46	structure	structure	NN
cord-310192-8x37nx4s	272	47	in	in	IN
cord-310192-8x37nx4s	272	48	RNA	RNA	NNP
cord-310192-8x37nx4s	272	49	NMR	NMR	NNP
cord-310192-8x37nx4s	272	50	scaler	scaler	NN
cord-310192-8x37nx4s	272	51	couplings	coupling	NNS
cord-310192-8x37nx4s	272	52	across	across	IN
cord-310192-8x37nx4s	272	53	Watson	Watson	NNP
cord-310192-8x37nx4s	272	54	-	-	HYPH
cord-310192-8x37nx4s	272	55	Crick	Crick	NNP
cord-310192-8x37nx4s	272	56	base	base	NN
cord-310192-8x37nx4s	272	57	pair	pair	NN
cord-310192-8x37nx4s	272	58	hydrogen	hydrogen	NN
cord-310192-8x37nx4s	272	59	bonds	bond	NNS
cord-310192-8x37nx4s	272	60	in	in	IN
cord-310192-8x37nx4s	272	61	DNA	dna	NN
cord-310192-8x37nx4s	272	62	observed	observe	VBN
cord-310192-8x37nx4s	272	63	by	by	IN
cord-310192-8x37nx4s	272	64	transverse	transverse	JJ
cord-310192-8x37nx4s	272	65	relaxation	relaxation	NN
cord-310192-8x37nx4s	272	66	optimized	optimize	VBN
cord-310192-8x37nx4s	272	67	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	272	68	Attenuated	attenuated	JJ
cord-310192-8x37nx4s	272	69	T2	T2	NNP
cord-310192-8x37nx4s	272	70	relaxation	relaxation	NN
cord-310192-8x37nx4s	272	71	by	by	IN
cord-310192-8x37nx4s	272	72	mutual	mutual	JJ
cord-310192-8x37nx4s	272	73	cancellation	cancellation	NN
cord-310192-8x37nx4s	272	74	of	of	IN
cord-310192-8x37nx4s	272	75	dipole	dipole	JJ
cord-310192-8x37nx4s	272	76	-	-	HYPH
cord-310192-8x37nx4s	272	77	dipole	dipole	NN
cord-310192-8x37nx4s	272	78	coupling	coupling	NN
cord-310192-8x37nx4s	272	79	and	and	CC
cord-310192-8x37nx4s	272	80	chemical	chemical	NN
cord-310192-8x37nx4s	272	81	shift	shift	NN
cord-310192-8x37nx4s	273	1	anisotropy	anisotropy	NNP
cord-310192-8x37nx4s	273	2	indicates	indicate	VBZ
cord-310192-8x37nx4s	273	3	an	an	DT
cord-310192-8x37nx4s	273	4	avenue	avenue	NN
cord-310192-8x37nx4s	273	5	to	to	IN
cord-310192-8x37nx4s	273	6	NMR	NMR	NNP
cord-310192-8x37nx4s	273	7	structures	structure	NNS
cord-310192-8x37nx4s	273	8	of	of	IN
cord-310192-8x37nx4s	273	9	very	very	RB
cord-310192-8x37nx4s	273	10	large	large	JJ
cord-310192-8x37nx4s	273	11	biological	biological	JJ
cord-310192-8x37nx4s	273	12	macromolecules	macromolecule	NNS
cord-310192-8x37nx4s	273	13	in	in	IN
cord-310192-8x37nx4s	273	14	solution	solution	NN
cord-310192-8x37nx4s	274	1	ykkC	ykkc	NN
cord-310192-8x37nx4s	274	2	riboswitches	riboswitche	NNS
cord-310192-8x37nx4s	274	3	employ	employ	VBP
cord-310192-8x37nx4s	274	4	an	an	DT
cord-310192-8x37nx4s	274	5	add	add	NN
cord-310192-8x37nx4s	274	6	-	-	HYPH
cord-310192-8x37nx4s	274	7	on	on	RP
cord-310192-8x37nx4s	274	8	helix	helix	NN
cord-310192-8x37nx4s	274	9	to	to	TO
cord-310192-8x37nx4s	274	10	adjust	adjust	VB
cord-310192-8x37nx4s	274	11	specificity	specificity	NN
cord-310192-8x37nx4s	274	12	for	for	IN
cord-310192-8x37nx4s	274	13	polyanionic	polyanionic	NNP
cord-310192-8x37nx4s	274	14	ligands	ligands	NNPS
cord-310192-8x37nx4s	274	15	Group	Group	NNP
cord-310192-8x37nx4s	274	16	II	II	NNP
cord-310192-8x37nx4s	274	17	intron	intron	NN
cord-310192-8x37nx4s	274	18	self	self	NN
cord-310192-8x37nx4s	274	19	-	-	HYPH
cord-310192-8x37nx4s	274	20	splicing	splice	VBG
cord-310192-8x37nx4s	274	21	Structure	Structure	NNP
cord-310192-8x37nx4s	274	22	of	of	IN
cord-310192-8x37nx4s	274	23	a	a	DT
cord-310192-8x37nx4s	274	24	group	group	NN
cord-310192-8x37nx4s	274	25	II	ii	CD
cord-310192-8x37nx4s	274	26	intron	intron	NN
cord-310192-8x37nx4s	274	27	in	in	IN
cord-310192-8x37nx4s	274	28	complex	complex	NN
cord-310192-8x37nx4s	274	29	with	with	IN
cord-310192-8x37nx4s	274	30	its	-PRON-	PRP$
cord-310192-8x37nx4s	274	31	reverse	reverse	JJ
cord-310192-8x37nx4s	274	32	transcriptase	transcriptase	NN
cord-310192-8x37nx4s	274	33	Three	three	CD
cord-310192-8x37nx4s	274	34	-	-	HYPH
cord-310192-8x37nx4s	274	35	state	state	NN
cord-310192-8x37nx4s	274	36	mechanism	mechanism	NN
cord-310192-8x37nx4s	274	37	couples	couple	NNS
cord-310192-8x37nx4s	274	38	ligand	ligand	VBP
cord-310192-8x37nx4s	274	39	and	and	CC
cord-310192-8x37nx4s	274	40	temperature	temperature	NN
cord-310192-8x37nx4s	274	41	sensing	sensing	NN
cord-310192-8x37nx4s	274	42	in	in	IN
cord-310192-8x37nx4s	274	43	riboswitches	riboswitches	NNP
cord-310192-8x37nx4s	274	44	Structure	Structure	NNP
cord-310192-8x37nx4s	274	45	-	-	HYPH
cord-310192-8x37nx4s	274	46	based	base	VBN
cord-310192-8x37nx4s	274	47	mechanistic	mechanistic	JJ
cord-310192-8x37nx4s	274	48	insights	insight	NNS
cord-310192-8x37nx4s	274	49	into	into	IN
cord-310192-8x37nx4s	274	50	catalysis	catalysis	NN
cord-310192-8x37nx4s	274	51	by	by	IN
cord-310192-8x37nx4s	274	52	small	small	JJ
cord-310192-8x37nx4s	274	53	self	self	NN
cord-310192-8x37nx4s	274	54	-	-	HYPH
cord-310192-8x37nx4s	274	55	cleaving	cleave	VBG
cord-310192-8x37nx4s	274	56	ribozymes	ribozyme	NNS
cord-310192-8x37nx4s	275	1	RNA	RNA	NNP
cord-310192-8x37nx4s	275	2	structure	structure	NN
cord-310192-8x37nx4s	275	3	:	:	:
cord-310192-8x37nx4s	275	4	Software	Software	NNP
cord-310192-8x37nx4s	275	5	for	for	IN
cord-310192-8x37nx4s	275	6	RNA	RNA	NNP
cord-310192-8x37nx4s	275	7	secondary	secondary	JJ
cord-310192-8x37nx4s	275	8	structure	structure	NN
cord-310192-8x37nx4s	275	9	prediction	prediction	NN
cord-310192-8x37nx4s	275	10	and	and	CC
cord-310192-8x37nx4s	275	11	analysis	analysis	NN
cord-310192-8x37nx4s	276	1	Mapping	map	VBG
cord-310192-8x37nx4s	276	2	the	the	DT
cord-310192-8x37nx4s	276	3	landscape	landscape	NN
cord-310192-8x37nx4s	276	4	of	of	IN
cord-310192-8x37nx4s	276	5	RNA	RNA	NNP
cord-310192-8x37nx4s	276	6	dynamics	dynamic	NNS
cord-310192-8x37nx4s	276	7	with	with	IN
cord-310192-8x37nx4s	276	8	NMR	NMR	NNP
cord-310192-8x37nx4s	276	9	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	276	10	Probing	probe	VBG
cord-310192-8x37nx4s	276	11	the	the	DT
cord-310192-8x37nx4s	276	12	structural	structural	JJ
cord-310192-8x37nx4s	276	13	dynamics	dynamic	NNS
cord-310192-8x37nx4s	276	14	of	of	IN
cord-310192-8x37nx4s	276	15	proteins	protein	NNS
cord-310192-8x37nx4s	276	16	and	and	CC
cord-310192-8x37nx4s	276	17	nucleic	nucleic	JJ
cord-310192-8x37nx4s	276	18	acids	acid	NNS
cord-310192-8x37nx4s	276	19	with	with	IN
cord-310192-8x37nx4s	276	20	optical	optical	JJ
cord-310192-8x37nx4s	276	21	tweezers	tweezer	NNS
cord-310192-8x37nx4s	276	22	Subunit	subunit	NN
cord-310192-8x37nx4s	276	23	conformational	conformational	JJ
cord-310192-8x37nx4s	276	24	variation	variation	NN
cord-310192-8x37nx4s	276	25	within	within	IN
cord-310192-8x37nx4s	276	26	individual	individual	JJ
cord-310192-8x37nx4s	276	27	GroEL	groel	NN
cord-310192-8x37nx4s	276	28	oligomers	oligomer	NNS
cord-310192-8x37nx4s	276	29	resolved	resolve	VBN
cord-310192-8x37nx4s	276	30	by	by	IN
cord-310192-8x37nx4s	276	31	Cryo	Cryo	NNP
cord-310192-8x37nx4s	276	32	-	-	HYPH
cord-310192-8x37nx4s	276	33	EM	EM	NNP
cord-310192-8x37nx4s	277	1	The	the	DT
cord-310192-8x37nx4s	277	2	structural	structural	JJ
cord-310192-8x37nx4s	277	3	and	and	CC
cord-310192-8x37nx4s	277	4	functional	functional	JJ
cord-310192-8x37nx4s	277	5	diversity	diversity	NN
cord-310192-8x37nx4s	277	6	of	of	IN
cord-310192-8x37nx4s	277	7	metabolite	metabolite	NN
cord-310192-8x37nx4s	277	8	-	-	HYPH
cord-310192-8x37nx4s	277	9	binding	bind	VBG
cord-310192-8x37nx4s	277	10	riboswitches	riboswitche	NNS
cord-310192-8x37nx4s	277	11	Synthesis	Synthesis	NNP
cord-310192-8x37nx4s	277	12	and	and	CC
cord-310192-8x37nx4s	277	13	NMR	NMR	NNP
cord-310192-8x37nx4s	277	14	of	of	IN
cord-310192-8x37nx4s	277	15	RNA	RNA	NNP
cord-310192-8x37nx4s	277	16	with	with	IN
cord-310192-8x37nx4s	277	17	selective	selective	JJ
cord-310192-8x37nx4s	277	18	isotopic	isotopic	JJ
cord-310192-8x37nx4s	277	19	enrichment	enrichment	NN
cord-310192-8x37nx4s	277	20	in	in	IN
cord-310192-8x37nx4s	277	21	the	the	DT
cord-310192-8x37nx4s	277	22	bases	basis	NNS
cord-310192-8x37nx4s	277	23	Preparation	Preparation	NNP
cord-310192-8x37nx4s	277	24	of	of	IN
cord-310192-8x37nx4s	277	25	specifically	specifically	RB
cord-310192-8x37nx4s	277	26	2	2	CD
cord-310192-8x37nx4s	277	27	H	h	NN
cord-310192-8x37nx4s	277	28	-	-	HYPH
cord-310192-8x37nx4s	277	29	and	and	CC
cord-310192-8x37nx4s	277	30	13	13	CD
cord-310192-8x37nx4s	277	31	C	c	NN
cord-310192-8x37nx4s	277	32	-	-	HYPH
cord-310192-8x37nx4s	277	33	labeled	label	VBN
cord-310192-8x37nx4s	277	34	ribonucleotides	ribonucleotide	NNS
cord-310192-8x37nx4s	278	1	Structural	structural	JJ
cord-310192-8x37nx4s	278	2	analysis	analysis	NN
cord-310192-8x37nx4s	278	3	of	of	IN
cord-310192-8x37nx4s	278	4	RNA	RNA	NNP
cord-310192-8x37nx4s	278	5	using	use	VBG
cord-310192-8x37nx4s	278	6	chemical	chemical	JJ
cord-310192-8x37nx4s	278	7	and	and	CC
cord-310192-8x37nx4s	278	8	enzymatic	enzymatic	JJ
cord-310192-8x37nx4s	278	9	probing	probing	NN
cord-310192-8x37nx4s	278	10	monitored	monitor	VBN
cord-310192-8x37nx4s	278	11	by	by	IN
cord-310192-8x37nx4s	278	12	primer	primer	NN
cord-310192-8x37nx4s	278	13	extension	extension	NN
cord-310192-8x37nx4s	278	14	Crystal	Crystal	NNP
cord-310192-8x37nx4s	278	15	structure	structure	NN
cord-310192-8x37nx4s	278	16	of	of	IN
cord-310192-8x37nx4s	278	17	the	the	DT
cord-310192-8x37nx4s	278	18	Varkud	Varkud	NNP
cord-310192-8x37nx4s	278	19	satellite	satellite	NN
cord-310192-8x37nx4s	278	20	ribozyme	ribozyme	NNP
cord-310192-8x37nx4s	278	21	RNA	RNA	NNP
cord-310192-8x37nx4s	278	22	structure	structure	NN
cord-310192-8x37nx4s	278	23	through	through	IN
cord-310192-8x37nx4s	278	24	multidimensional	multidimensional	JJ
cord-310192-8x37nx4s	278	25	chemical	chemical	NN
cord-310192-8x37nx4s	278	26	mapping	mapping	NN
cord-310192-8x37nx4s	278	27	Major	major	JJ
cord-310192-8x37nx4s	278	28	groove	groove	NN
cord-310192-8x37nx4s	278	29	width	width	NN
cord-310192-8x37nx4s	278	30	variations	variation	NNS
cord-310192-8x37nx4s	278	31	in	in	IN
cord-310192-8x37nx4s	278	32	RNA	RNA	NNP
cord-310192-8x37nx4s	278	33	structures	structure	NNS
cord-310192-8x37nx4s	278	34	determined	determine	VBN
cord-310192-8x37nx4s	278	35	by	by	IN
cord-310192-8x37nx4s	278	36	NMR	nmr	NN
cord-310192-8x37nx4s	278	37	and	and	CC
cord-310192-8x37nx4s	278	38	impact	impact	NN
cord-310192-8x37nx4s	278	39	of	of	IN
cord-310192-8x37nx4s	278	40	13	13	CD
cord-310192-8x37nx4s	278	41	C	c	NN
cord-310192-8x37nx4s	278	42	residual	residual	JJ
cord-310192-8x37nx4s	278	43	chemical	chemical	NN
cord-310192-8x37nx4s	278	44	shift	shift	NN
cord-310192-8x37nx4s	278	45	anisotropy	anisotropy	NN
cord-310192-8x37nx4s	278	46	and	and	CC
cord-310192-8x37nx4s	278	47	1	1	CD
cord-310192-8x37nx4s	278	48	H-13	h-13	NN
cord-310192-8x37nx4s	278	49	C	c	NN
cord-310192-8x37nx4s	278	50	residual	residual	JJ
cord-310192-8x37nx4s	278	51	dipolar	dipolar	JJ
cord-310192-8x37nx4s	278	52	coupling	coupling	NN
cord-310192-8x37nx4s	278	53	on	on	IN
cord-310192-8x37nx4s	278	54	refinement	refinement	NN
cord-310192-8x37nx4s	278	55	Crystal	Crystal	NNP
cord-310192-8x37nx4s	278	56	structure	structure	NN
cord-310192-8x37nx4s	278	57	of	of	IN
cord-310192-8x37nx4s	278	58	a	a	DT
cord-310192-8x37nx4s	278	59	self	self	NN
cord-310192-8x37nx4s	278	60	-	-	HYPH
cord-310192-8x37nx4s	278	61	spliced	splice	VBN
cord-310192-8x37nx4s	278	62	group	group	NN
cord-310192-8x37nx4s	278	63	II	II	NNP
cord-310192-8x37nx4s	278	64	intron	intron	NN
cord-310192-8x37nx4s	278	65	Structural	structural	JJ
cord-310192-8x37nx4s	278	66	basis	basis	NN
cord-310192-8x37nx4s	278	67	for	for	IN
cord-310192-8x37nx4s	278	68	exon	exon	NN
cord-310192-8x37nx4s	278	69	recognition	recognition	NN
cord-310192-8x37nx4s	278	70	by	by	IN
cord-310192-8x37nx4s	278	71	a	a	DT
cord-310192-8x37nx4s	278	72	group	group	NN
cord-310192-8x37nx4s	278	73	II	II	NNP
cord-310192-8x37nx4s	278	74	intron	intron	NN
cord-310192-8x37nx4s	278	75	Preparation	preparation	NN
cord-310192-8x37nx4s	278	76	of	of	IN
cord-310192-8x37nx4s	278	77	large	large	JJ
cord-310192-8x37nx4s	278	78	RNA	RNA	NNP
cord-310192-8x37nx4s	278	79	oligonucleotides	oligonucleotide	NNS
cord-310192-8x37nx4s	278	80	with	with	IN
cord-310192-8x37nx4s	278	81	complementary	complementary	JJ
cord-310192-8x37nx4s	278	82	isotope	isotope	NN
cord-310192-8x37nx4s	278	83	-	-	HYPH
cord-310192-8x37nx4s	278	84	labeled	label	VBN
cord-310192-8x37nx4s	278	85	segments	segment	NNS
cord-310192-8x37nx4s	278	86	for	for	IN
cord-310192-8x37nx4s	278	87	NMR	NMR	NNP
cord-310192-8x37nx4s	278	88	structural	structural	JJ
cord-310192-8x37nx4s	278	89	studies	study	NNS
cord-310192-8x37nx4s	278	90	NMR	NMR	NNP
cord-310192-8x37nx4s	278	91	structure	structure	NN
cord-310192-8x37nx4s	278	92	of	of	IN
cord-310192-8x37nx4s	278	93	the	the	DT
cord-310192-8x37nx4s	278	94	full	full	JJ
cord-310192-8x37nx4s	278	95	-	-	HYPH
cord-310192-8x37nx4s	278	96	length	length	NN
cord-310192-8x37nx4s	278	97	linear	linear	JJ
cord-310192-8x37nx4s	278	98	dimer	dimer	NN
cord-310192-8x37nx4s	278	99	of	of	IN
cord-310192-8x37nx4s	278	100	stem	stem	NN
cord-310192-8x37nx4s	278	101	-	-	HYPH
cord-310192-8x37nx4s	278	102	loop-1	loop-1	NNP
cord-310192-8x37nx4s	278	103	RNA	RNA	NNP
cord-310192-8x37nx4s	278	104	in	in	IN
cord-310192-8x37nx4s	278	105	the	the	DT
cord-310192-8x37nx4s	278	106	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	278	107	dimer	dimer	NN
cord-310192-8x37nx4s	278	108	initiation	initiation	NN
cord-310192-8x37nx4s	278	109	site	site	NN
cord-310192-8x37nx4s	278	110	Probing	probe	VBG
cord-310192-8x37nx4s	278	111	conformational	conformational	JJ
cord-310192-8x37nx4s	278	112	dynamics	dynamic	NNS
cord-310192-8x37nx4s	278	113	in	in	IN
cord-310192-8x37nx4s	278	114	biomolecules	biomolecule	NNS
cord-310192-8x37nx4s	278	115	via	via	IN
cord-310192-8x37nx4s	278	116	chemical	chemical	NN
cord-310192-8x37nx4s	278	117	exchange	exchange	NN
cord-310192-8x37nx4s	278	118	saturation	saturation	NN
cord-310192-8x37nx4s	278	119	transfer	transfer	NN
cord-310192-8x37nx4s	279	1	:	:	:
cord-310192-8x37nx4s	279	2	A	a	DT
cord-310192-8x37nx4s	279	3	primer	primer	NN
cord-310192-8x37nx4s	279	4	NMR	NMR	NNP
cord-310192-8x37nx4s	279	5	investigation	investigation	NN
cord-310192-8x37nx4s	279	6	of	of	IN
cord-310192-8x37nx4s	279	7	RNA	RNA	NNP
cord-310192-8x37nx4s	279	8	structure	structure	NN
cord-310192-8x37nx4s	279	9	Structure	structure	NN
cord-310192-8x37nx4s	279	10	-	-	HYPH
cord-310192-8x37nx4s	279	11	activity	activity	NN
cord-310192-8x37nx4s	279	12	relationship	relationship	NN
cord-310192-8x37nx4s	279	13	of	of	IN
cord-310192-8x37nx4s	279	14	flavin	flavin	JJ
cord-310192-8x37nx4s	279	15	analogues	analogue	NNS
cord-310192-8x37nx4s	279	16	that	that	WDT
cord-310192-8x37nx4s	279	17	target	target	VBP
cord-310192-8x37nx4s	279	18	the	the	DT
cord-310192-8x37nx4s	279	19	flavin	flavin	NNP
cord-310192-8x37nx4s	279	20	mononucleotide	mononucleotide	NNP
cord-310192-8x37nx4s	279	21	riboswitch	riboswitch	NN
cord-310192-8x37nx4s	279	22	Single	single	JJ
cord-310192-8x37nx4s	279	23	particle	particle	NN
cord-310192-8x37nx4s	279	24	electron	electron	NN
cord-310192-8x37nx4s	279	25	cryomicroscopy	cryomicroscopy	RB
cord-310192-8x37nx4s	279	26	:	:	:
cord-310192-8x37nx4s	279	27	Trends	trend	NNS
cord-310192-8x37nx4s	279	28	,	,	,
cord-310192-8x37nx4s	279	29	issues	issue	NNS
cord-310192-8x37nx4s	279	30	and	and	CC
cord-310192-8x37nx4s	279	31	future	future	JJ
cord-310192-8x37nx4s	279	32	perspective	perspective	NN
cord-310192-8x37nx4s	279	33	Mechanistic	mechanistic	JJ
cord-310192-8x37nx4s	279	34	insights	insight	NNS
cord-310192-8x37nx4s	279	35	into	into	IN
cord-310192-8x37nx4s	279	36	temperature	temperature	NN
cord-310192-8x37nx4s	279	37	-	-	HYPH
cord-310192-8x37nx4s	279	38	dependent	dependent	JJ
cord-310192-8x37nx4s	279	39	regulation	regulation	NN
cord-310192-8x37nx4s	279	40	of	of	IN
cord-310192-8x37nx4s	279	41	the	the	DT
cord-310192-8x37nx4s	279	42	simple	simple	JJ
cord-310192-8x37nx4s	279	43	cyanobacterial	cyanobacterial	JJ
cord-310192-8x37nx4s	279	44	hsp17	hsp17	ADD
cord-310192-8x37nx4s	279	45	RNA	RNA	NNP
cord-310192-8x37nx4s	279	46	thermometer	thermometer	NN
cord-310192-8x37nx4s	279	47	at	at	IN
cord-310192-8x37nx4s	279	48	base	base	JJ
cord-310192-8x37nx4s	279	49	-	-	HYPH
cord-310192-8x37nx4s	279	50	pair	pair	NN
cord-310192-8x37nx4s	279	51	resolution	resolution	NN
cord-310192-8x37nx4s	279	52	A	a	DT
cord-310192-8x37nx4s	279	53	method	method	NN
cord-310192-8x37nx4s	279	54	for	for	IN
cord-310192-8x37nx4s	279	55	helical	helical	JJ
cord-310192-8x37nx4s	279	56	RNA	RNA	NNP
cord-310192-8x37nx4s	279	57	global	global	JJ
cord-310192-8x37nx4s	279	58	structure	structure	NN
cord-310192-8x37nx4s	279	59	determination	determination	NN
cord-310192-8x37nx4s	279	60	in	in	IN
cord-310192-8x37nx4s	279	61	solution	solution	NN
cord-310192-8x37nx4s	279	62	using	use	VBG
cord-310192-8x37nx4s	279	63	small	small	JJ
cord-310192-8x37nx4s	279	64	-	-	HYPH
cord-310192-8x37nx4s	279	65	angle	angle	NN
cord-310192-8x37nx4s	279	66	X	x	NN
cord-310192-8x37nx4s	279	67	-	-	NN
cord-310192-8x37nx4s	279	68	ray	ray	NN
cord-310192-8x37nx4s	279	69	scattering	scattering	NN
cord-310192-8x37nx4s	279	70	and	and	CC
cord-310192-8x37nx4s	279	71	NMR	NMR	NNP
cord-310192-8x37nx4s	279	72	measurements	measurement	NNS
cord-310192-8x37nx4s	279	73	Principles	Principles	NNPS
cord-310192-8x37nx4s	279	74	for	for	IN
cord-310192-8x37nx4s	279	75	targeting	target	VBG
cord-310192-8x37nx4s	279	76	RNA	RNA	NNP
cord-310192-8x37nx4s	279	77	with	with	IN
cord-310192-8x37nx4s	279	78	drug	drug	NN
cord-310192-8x37nx4s	279	79	-	-	HYPH
cord-310192-8x37nx4s	279	80	like	like	JJ
cord-310192-8x37nx4s	279	81	small	small	JJ
cord-310192-8x37nx4s	279	82	molecules	molecule	NNS
cord-310192-8x37nx4s	279	83	Architecture	architecture	NN
cord-310192-8x37nx4s	279	84	and	and	CC
cord-310192-8x37nx4s	279	85	secondary	secondary	JJ
cord-310192-8x37nx4s	279	86	structure	structure	NN
cord-310192-8x37nx4s	279	87	of	of	IN
cord-310192-8x37nx4s	279	88	an	an	DT
cord-310192-8x37nx4s	279	89	entire	entire	JJ
cord-310192-8x37nx4s	279	90	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	279	91	RNA	RNA	NNP
cord-310192-8x37nx4s	279	92	genome	genome	NN
cord-310192-8x37nx4s	279	93	Advances	advance	NNS
cord-310192-8x37nx4s	279	94	in	in	IN
cord-310192-8x37nx4s	279	95	RNA	RNA	NNP
cord-310192-8x37nx4s	279	96	structure	structure	NN
cord-310192-8x37nx4s	279	97	analysis	analysis	NN
cord-310192-8x37nx4s	279	98	by	by	IN
cord-310192-8x37nx4s	279	99	chemical	chemical	NN
cord-310192-8x37nx4s	279	100	probing	probe	VBG
cord-310192-8x37nx4s	279	101	NMR	nmr	NN
cord-310192-8x37nx4s	279	102	of	of	IN
cord-310192-8x37nx4s	279	103	proteins	protein	NNS
cord-310192-8x37nx4s	279	104	and	and	CC
cord-310192-8x37nx4s	279	105	nucleic	nucleic	JJ
cord-310192-8x37nx4s	279	106	acids	acid	NNS
cord-310192-8x37nx4s	280	1	Determining	determine	VBG
cord-310192-8x37nx4s	280	2	RNA	RNA	NNP
cord-310192-8x37nx4s	280	3	solution	solution	NN
cord-310192-8x37nx4s	280	4	structure	structure	NN
cord-310192-8x37nx4s	280	5	by	by	IN
cord-310192-8x37nx4s	280	6	segmental	segmental	JJ
cord-310192-8x37nx4s	280	7	isotopic	isotopic	JJ
cord-310192-8x37nx4s	280	8	labeling	labeling	NN
cord-310192-8x37nx4s	280	9	and	and	CC
cord-310192-8x37nx4s	280	10	NMR	nmr	NN
cord-310192-8x37nx4s	280	11	:	:	:
cord-310192-8x37nx4s	280	12	Application	application	NN
cord-310192-8x37nx4s	280	13	to	to	IN
cord-310192-8x37nx4s	280	14	Caenorhabditis	Caenorhabditis	NNP
cord-310192-8x37nx4s	280	15	elegans	elegan	NNS
cord-310192-8x37nx4s	280	16	spliced	splice	VBN
cord-310192-8x37nx4s	280	17	leader	leader	NN
cord-310192-8x37nx4s	280	18	RNA	RNA	NNP
cord-310192-8x37nx4s	280	19	1	1	CD
cord-310192-8x37nx4s	280	20	Characterizing	Characterizing	NNP
cord-310192-8x37nx4s	280	21	RNA	RNA	NNP
cord-310192-8x37nx4s	280	22	excited	excite	VBD
cord-310192-8x37nx4s	280	23	states	state	NNS
cord-310192-8x37nx4s	280	24	using	use	VBG
cord-310192-8x37nx4s	280	25	NMR	NMR	NNP
cord-310192-8x37nx4s	280	26	relaxation	relaxation	NN
cord-310192-8x37nx4s	280	27	dispersion	dispersion	NN
cord-310192-8x37nx4s	280	28	Nmr	Nmr	NNP
cord-310192-8x37nx4s	280	29	experiments	experiment	NNS
cord-310192-8x37nx4s	280	30	for	for	IN
cord-310192-8x37nx4s	280	31	the	the	DT
cord-310192-8x37nx4s	280	32	measurement	measurement	NN
cord-310192-8x37nx4s	280	33	of	of	IN
cord-310192-8x37nx4s	280	34	carbon	carbon	NN
cord-310192-8x37nx4s	280	35	relaxation	relaxation	NN
cord-310192-8x37nx4s	280	36	properties	property	NNS
cord-310192-8x37nx4s	280	37	in	in	IN
cord-310192-8x37nx4s	280	38	highly	highly	RB
cord-310192-8x37nx4s	280	39	enriched	enrich	VBN
cord-310192-8x37nx4s	280	40	,	,	,
cord-310192-8x37nx4s	280	41	uniformly	uniformly	RB
cord-310192-8x37nx4s	280	42	13	13	CD
cord-310192-8x37nx4s	280	43	C	C	NNP
cord-310192-8x37nx4s	280	44	,	,	,
cord-310192-8x37nx4s	280	45	15	15	CD
cord-310192-8x37nx4s	280	46	N	n	CD
cord-310192-8x37nx4s	280	47	-	-	HYPH
cord-310192-8x37nx4s	280	48	labeled	label	VBN
cord-310192-8x37nx4s	280	49	proteins	protein	NNS
cord-310192-8x37nx4s	280	50	-	-	:
cord-310192-8x37nx4s	280	51	Application	application	NN
cord-310192-8x37nx4s	280	52	to	to	IN
cord-310192-8x37nx4s	280	53	13	13	CD
cord-310192-8x37nx4s	280	54	C(alpha	C(alpha	NNS
cord-310192-8x37nx4s	280	55	)	)	-RRB-
cord-310192-8x37nx4s	280	56	carbons	carbon	NNS
cord-310192-8x37nx4s	280	57	MQ	MQ	NNP
cord-310192-8x37nx4s	280	58	-	-	HYPH
cord-310192-8x37nx4s	280	59	HCN	HCN	NNP
cord-310192-8x37nx4s	280	60	-	-	HYPH
cord-310192-8x37nx4s	280	61	based	base	VBN
cord-310192-8x37nx4s	280	62	pulse	pulse	NN
cord-310192-8x37nx4s	280	63	sequences	sequence	NNS
cord-310192-8x37nx4s	280	64	for	for	IN
cord-310192-8x37nx4s	280	65	the	the	DT
cord-310192-8x37nx4s	280	66	measurement	measurement	NN
cord-310192-8x37nx4s	280	67	of	of	IN
cord-310192-8x37nx4s	280	68	13	13	CD
cord-310192-8x37nx4s	280	69	C1'-1	C1'-1	NNP
cord-310192-8x37nx4s	280	70	H1	H1	NNP
cord-310192-8x37nx4s	280	71	Structure	Structure	NNP
cord-310192-8x37nx4s	280	72	of	of	IN
cord-310192-8x37nx4s	280	73	the	the	DT
cord-310192-8x37nx4s	280	74	30	30	CD
cord-310192-8x37nx4s	280	75	kDa	kDa	NNP
cord-310192-8x37nx4s	280	76	HIV-1	HIV-1	NNP
cord-310192-8x37nx4s	280	77	RNA	RNA	NNP
cord-310192-8x37nx4s	280	78	dimerization	dimerization	NN
cord-310192-8x37nx4s	280	79	signal	signal	NN
cord-310192-8x37nx4s	280	80	by	by	IN
cord-310192-8x37nx4s	280	81	a	a	DT
cord-310192-8x37nx4s	280	82	hybrid	hybrid	JJ
cord-310192-8x37nx4s	280	83	Cryo	Cryo	NNP
cord-310192-8x37nx4s	280	84	-	-	HYPH
cord-310192-8x37nx4s	280	85	EM	EM	NNP
cord-310192-8x37nx4s	280	86	,	,	,
cord-310192-8x37nx4s	280	87	NMR	NMR	NNP
cord-310192-8x37nx4s	280	88	,	,	,
cord-310192-8x37nx4s	280	89	and	and	CC
cord-310192-8x37nx4s	280	90	molecular	molecular	JJ
cord-310192-8x37nx4s	280	91	dynamics	dynamic	NNS
cord-310192-8x37nx4s	281	1	approach	approach	NNP
cord-310192-8x37nx4s	282	1	An	an	DT
cord-310192-8x37nx4s	282	2	excited	excited	JJ
cord-310192-8x37nx4s	282	3	state	state	NN
cord-310192-8x37nx4s	282	4	underlies	underlie	VBZ
cord-310192-8x37nx4s	282	5	gene	gene	NN
cord-310192-8x37nx4s	282	6	regulation	regulation	NN
cord-310192-8x37nx4s	282	7	of	of	IN
cord-310192-8x37nx4s	282	8	a	a	DT
cord-310192-8x37nx4s	282	9	transcriptional	transcriptional	JJ
cord-310192-8x37nx4s	282	10	riboswitch	riboswitch	NN
cord-310192-8x37nx4s	282	11	Characterizing	characterize	VBG
cord-310192-8x37nx4s	282	12	slow	slow	JJ
cord-310192-8x37nx4s	282	13	chemical	chemical	NN
cord-310192-8x37nx4s	282	14	exchange	exchange	NN
cord-310192-8x37nx4s	282	15	in	in	IN
cord-310192-8x37nx4s	282	16	nucleic	nucleic	JJ
cord-310192-8x37nx4s	282	17	acids	acid	NNS
cord-310192-8x37nx4s	282	18	by	by	IN
cord-310192-8x37nx4s	282	19	carbon	carbon	NN
cord-310192-8x37nx4s	282	20	CEST	CEST	NNP
cord-310192-8x37nx4s	282	21	and	and	CC
cord-310192-8x37nx4s	282	22	low	low	JJ
cord-310192-8x37nx4s	282	23	spin	spin	NN
cord-310192-8x37nx4s	282	24	-	-	HYPH
cord-310192-8x37nx4s	282	25	lock	lock	NN
cord-310192-8x37nx4s	282	26	field	field	NN
cord-310192-8x37nx4s	282	27	R	r	NN
cord-310192-8x37nx4s	282	28	(	(	-LRB-
cord-310192-8x37nx4s	282	29	1rho	1rho	CD
cord-310192-8x37nx4s	282	30	)	)	-RRB-
cord-310192-8x37nx4s	282	31	NMR	NMR	NNP
cord-310192-8x37nx4s	282	32	spectroscopy	spectroscopy	NN
cord-310192-8x37nx4s	282	33	Crystal	Crystal	NNP
cord-310192-8x37nx4s	282	34	structure	structure	NN
cord-310192-8x37nx4s	282	35	of	of	IN
cord-310192-8x37nx4s	282	36	group	group	NN
cord-310192-8x37nx4s	282	37	II	II	NNP
cord-310192-8x37nx4s	282	38	intron	intron	NN
cord-310192-8x37nx4s	282	39	domain	domain	NN
cord-310192-8x37nx4s	282	40	1	1	CD
cord-310192-8x37nx4s	282	41	reveals	reveal	VBZ
cord-310192-8x37nx4s	282	42	a	a	DT
cord-310192-8x37nx4s	282	43	template	template	NN
cord-310192-8x37nx4s	282	44	for	for	IN
cord-310192-8x37nx4s	282	45	RNA	RNA	NNP
cord-310192-8x37nx4s	282	46	assembly	assembly	NNP
cord-310192-8x37nx4s	282	47	Measurement	Measurement	NNP
cord-310192-8x37nx4s	282	48	of	of	IN
cord-310192-8x37nx4s	282	49	small	small	JJ
cord-310192-8x37nx4s	282	50	scalar	scalar	JJ
cord-310192-8x37nx4s	282	51	and	and	CC
cord-310192-8x37nx4s	282	52	dipolar	dipolar	JJ
cord-310192-8x37nx4s	282	53	couplings	coupling	NNS
cord-310192-8x37nx4s	282	54	in	in	IN
cord-310192-8x37nx4s	282	55	purine	purine	NN
cord-310192-8x37nx4s	282	56	and	and	CC
cord-310192-8x37nx4s	282	57	pyrimidine	pyrimidine	NN
cord-310192-8x37nx4s	282	58	bases	basis	NNS
cord-310192-8x37nx4s	282	59	NMR	NMR	NNP
cord-310192-8x37nx4s	282	60	studies	study	NNS
cord-310192-8x37nx4s	282	61	of	of	IN
cord-310192-8x37nx4s	282	62	HAR1	HAR1	NNP
cord-310192-8x37nx4s	282	63	RNA	RNA	NNP
cord-310192-8x37nx4s	282	64	secondary	secondary	JJ
cord-310192-8x37nx4s	282	65	structures	structure	NNS
cord-310192-8x37nx4s	282	66	reveal	reveal	VBP
cord-310192-8x37nx4s	282	67	conformational	conformational	JJ
cord-310192-8x37nx4s	282	68	dynamics	dynamic	NNS
cord-310192-8x37nx4s	282	69	in	in	IN
cord-310192-8x37nx4s	282	70	the	the	DT
cord-310192-8x37nx4s	282	71	human	human	JJ
cord-310192-8x37nx4s	282	72	RNA	RNA	NNP
cord-310192-8x37nx4s	282	73	DMS	DMS	NNP
cord-310192-8x37nx4s	282	74	-	-	HYPH
cord-310192-8x37nx4s	282	75	MaPseq	MaPseq	NNP
cord-310192-8x37nx4s	282	76	for	for	IN
cord-310192-8x37nx4s	282	77	genome	genome	NN
cord-310192-8x37nx4s	282	78	-	-	HYPH
cord-310192-8x37nx4s	282	79	wide	wide	RB
cord-310192-8x37nx4s	282	80	or	or	CC
cord-310192-8x37nx4s	282	81	targeted	target	VBN
cord-310192-8x37nx4s	282	82	RNA	RNA	NNP
cord-310192-8x37nx4s	282	83	structure	structure	NN
cord-310192-8x37nx4s	282	84	probing	probe	VBG
cord-310192-8x37nx4s	282	85	in	in	IN
cord-310192-8x37nx4s	282	86	vivo	vivo	NNP
cord-310192-8x37nx4s	282	87	Solution	Solution	NNP
cord-310192-8x37nx4s	282	88	structure	structure	NN
cord-310192-8x37nx4s	282	89	of	of	IN
cord-310192-8x37nx4s	282	90	the	the	DT
cord-310192-8x37nx4s	282	91	cap	cap	NN
cord-310192-8x37nx4s	282	92	-	-	HYPH
cord-310192-8x37nx4s	282	93	independent	independent	JJ
cord-310192-8x37nx4s	282	94	translational	translational	JJ
cord-310192-8x37nx4s	282	95	enhancer	enhancer	NN
cord-310192-8x37nx4s	282	96	and	and	CC
cord-310192-8x37nx4s	282	97	ribosome	ribosome	NN
cord-310192-8x37nx4s	282	98	-	-	HYPH
cord-310192-8x37nx4s	282	99	binding	bind	VBG
cord-310192-8x37nx4s	282	100	element	element	NN
cord-310192-8x37nx4s	282	101	in	in	IN
cord-310192-8x37nx4s	282	102	the	the	DT
cord-310192-8x37nx4s	282	103	3	3	CD
cord-310192-8x37nx4s	282	104	'	'	POS
cord-310192-8x37nx4s	282	105	UTR	UTR	NNP
cord-310192-8x37nx4s	282	106	of	of	IN
cord-310192-8x37nx4s	282	107	turnip	turnip	NN
cord-310192-8x37nx4s	282	108	crinkle	crinkle	NN
cord-310192-8x37nx4s	282	109	virus	virus	NN
cord-310192-8x37nx4s	282	110	Advances	advance	VBZ
cord-310192-8x37nx4s	282	111	that	that	WDT
cord-310192-8x37nx4s	282	112	facilitate	facilitate	VBP
cord-310192-8x37nx4s	282	113	the	the	DT
cord-310192-8x37nx4s	282	114	study	study	NN
cord-310192-8x37nx4s	282	115	of	of	IN
cord-310192-8x37nx4s	282	116	large	large	JJ
cord-310192-8x37nx4s	282	117	RNA	RNA	NNP
cord-310192-8x37nx4s	282	118	structure	structure	NN
cord-310192-8x37nx4s	282	119	and	and	CC
cord-310192-8x37nx4s	282	120	dynamics	dynamic	NNS
cord-310192-8x37nx4s	282	121	by	by	IN
cord-310192-8x37nx4s	282	122	nuclear	nuclear	JJ
cord-310192-8x37nx4s	282	123	magnetic	magnetic	JJ
cord-310192-8x37nx4s	282	124	resonance	resonance	NN
cord-310192-8x37nx4s	282	125	spectroscopy	spectroscopy	NN