id	sid	tid	token	lemma	pos
cord-264489-h1n9ywbd	1	1	key	key	JJ
cord-264489-h1n9ywbd	1	2	:	:	:
cord-264489-h1n9ywbd	1	3	cord-264489-h1n9ywbd	cord-264489-h1n9ywbd	NN
cord-264489-h1n9ywbd	1	4	authors	author	NNS
cord-264489-h1n9ywbd	1	5	:	:	:
cord-264489-h1n9ywbd	1	6	Roy	Roy	NNP
cord-264489-h1n9ywbd	1	7	,	,	,
cord-264489-h1n9ywbd	1	8	Urmi	Urmi	NNP
cord-264489-h1n9ywbd	1	9	title	title	NN
cord-264489-h1n9ywbd	1	10	:	:	:
cord-264489-h1n9ywbd	1	11	Insight	insight	NN
cord-264489-h1n9ywbd	1	12	into	into	IN
cord-264489-h1n9ywbd	1	13	the	the	DT
cord-264489-h1n9ywbd	1	14	Structures	structure	NNS
cord-264489-h1n9ywbd	1	15	of	of	IN
cord-264489-h1n9ywbd	1	16	Interleukin-18	Interleukin-18	NNP
cord-264489-h1n9ywbd	1	17	Systems	Systems	NNPS
cord-264489-h1n9ywbd	1	18	date	date	NN
cord-264489-h1n9ywbd	1	19	:	:	:
cord-264489-h1n9ywbd	1	20	2020	2020	CD
cord-264489-h1n9ywbd	1	21	-	-	HYPH
cord-264489-h1n9ywbd	1	22	07	07	CD
cord-264489-h1n9ywbd	1	23	-	-	HYPH
cord-264489-h1n9ywbd	1	24	31	31	CD
cord-264489-h1n9ywbd	1	25	journal	journal	NN
cord-264489-h1n9ywbd	1	26	:	:	:
cord-264489-h1n9ywbd	1	27	Comput	Comput	NNP
cord-264489-h1n9ywbd	1	28	Biol	Biol	NNP
cord-264489-h1n9ywbd	1	29	Chem	Chem	NNP
cord-264489-h1n9ywbd	1	30	DOI	doi	NN
cord-264489-h1n9ywbd	1	31	:	:	:
cord-264489-h1n9ywbd	1	32	10.1016/	10.1016/	CD
cord-264489-h1n9ywbd	2	1	j.compbiolchem.2020.107353	j.compbiolchem.2020.107353	NNP
cord-264489-h1n9ywbd	2	2	sha	sha	NNP
cord-264489-h1n9ywbd	2	3	:	:	:
cord-264489-h1n9ywbd	2	4	19ef280db71285b08d15f8e315960a095a0e55ed	19ef280db71285b08d15f8e315960a095a0e55ed	CD
cord-264489-h1n9ywbd	2	5	doc_id	doc_id	CD
cord-264489-h1n9ywbd	2	6	:	:	:
cord-264489-h1n9ywbd	2	7	264489	264489	CD
cord-264489-h1n9ywbd	2	8	cord_uid	cord_uid	NNS
cord-264489-h1n9ywbd	2	9	:	:	:
cord-264489-h1n9ywbd	3	1	h1n9ywbd	h1n9ywbd	NNP
cord-264489-h1n9ywbd	3	2	Structure	structure	NN
cord-264489-h1n9ywbd	3	3	-	-	HYPH
cord-264489-h1n9ywbd	3	4	based	base	VBN
cord-264489-h1n9ywbd	3	5	molecular	molecular	JJ
cord-264489-h1n9ywbd	3	6	designs	design	NNS
cord-264489-h1n9ywbd	3	7	play	play	VBP
cord-264489-h1n9ywbd	3	8	a	a	DT
cord-264489-h1n9ywbd	3	9	critical	critical	JJ
cord-264489-h1n9ywbd	3	10	role	role	NN
cord-264489-h1n9ywbd	3	11	in	in	IN
cord-264489-h1n9ywbd	3	12	the	the	DT
cord-264489-h1n9ywbd	3	13	context	context	NN
cord-264489-h1n9ywbd	3	14	of	of	IN
cord-264489-h1n9ywbd	3	15	next	next	JJ
cord-264489-h1n9ywbd	3	16	generation	generation	NN
cord-264489-h1n9ywbd	3	17	drug	drug	NN
cord-264489-h1n9ywbd	3	18	development	development	NN
cord-264489-h1n9ywbd	3	19	.	.	.
cord-264489-h1n9ywbd	4	1	Besides	besides	IN
cord-264489-h1n9ywbd	4	2	their	-PRON-	PRP$
cord-264489-h1n9ywbd	4	3	fundamental	fundamental	JJ
cord-264489-h1n9ywbd	4	4	scientific	scientific	JJ
cord-264489-h1n9ywbd	4	5	aspects	aspect	NNS
cord-264489-h1n9ywbd	4	6	,	,	,
cord-264489-h1n9ywbd	4	7	the	the	DT
cord-264489-h1n9ywbd	4	8	findings	finding	NNS
cord-264489-h1n9ywbd	4	9	established	establish	VBN
cord-264489-h1n9ywbd	4	10	in	in	IN
cord-264489-h1n9ywbd	4	11	this	this	DT
cord-264489-h1n9ywbd	4	12	approach	approach	NN
cord-264489-h1n9ywbd	4	13	have	have	VBP
cord-264489-h1n9ywbd	4	14	significant	significant	JJ
cord-264489-h1n9ywbd	4	15	implications	implication	NNS
cord-264489-h1n9ywbd	4	16	in	in	IN
cord-264489-h1n9ywbd	4	17	the	the	DT
cord-264489-h1n9ywbd	4	18	expansions	expansion	NNS
cord-264489-h1n9ywbd	4	19	of	of	IN
cord-264489-h1n9ywbd	4	20	target	target	NN
cord-264489-h1n9ywbd	4	21	-	-	HYPH
cord-264489-h1n9ywbd	4	22	based	base	VBN
cord-264489-h1n9ywbd	4	23	therapies	therapy	NNS
cord-264489-h1n9ywbd	4	24	and	and	CC
cord-264489-h1n9ywbd	4	25	vaccines	vaccine	NNS
cord-264489-h1n9ywbd	4	26	.	.	.
cord-264489-h1n9ywbd	5	1	Interleukin-18	Interleukin-18	NNP
cord-264489-h1n9ywbd	5	2	(	(	-LRB-
cord-264489-h1n9ywbd	5	3	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	5	4	)	)	-RRB-
cord-264489-h1n9ywbd	5	5	,	,	,
cord-264489-h1n9ywbd	5	6	also	also	RB
cord-264489-h1n9ywbd	5	7	known	know	VBN
cord-264489-h1n9ywbd	5	8	as	as	IN
cord-264489-h1n9ywbd	5	9	interferon	interferon	NN
cord-264489-h1n9ywbd	5	10	gamma	gamma	NN
cord-264489-h1n9ywbd	5	11	(	(	-LRB-
cord-264489-h1n9ywbd	5	12	IFN	IFN	NNP
cord-264489-h1n9ywbd	5	13	-	-	HYPH
cord-264489-h1n9ywbd	5	14	γ	γ	NNP
cord-264489-h1n9ywbd	5	15	)	)	-RRB-
cord-264489-h1n9ywbd	5	16	inducing	induce	VBG
cord-264489-h1n9ywbd	5	17	factor	factor	NN
cord-264489-h1n9ywbd	5	18	,	,	,
cord-264489-h1n9ywbd	5	19	is	be	VBZ
cord-264489-h1n9ywbd	5	20	a	a	DT
cord-264489-h1n9ywbd	5	21	pro	pro	JJ
cord-264489-h1n9ywbd	5	22	-	-	JJ
cord-264489-h1n9ywbd	5	23	inflammatory	inflammatory	JJ
cord-264489-h1n9ywbd	5	24	cytokine	cytokine	NN
cord-264489-h1n9ywbd	5	25	.	.	.
cord-264489-h1n9ywbd	6	1	The	the	DT
cord-264489-h1n9ywbd	6	2	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	6	3	binds	bind	VBZ
cord-264489-h1n9ywbd	6	4	first	first	RB
cord-264489-h1n9ywbd	6	5	to	to	IN
cord-264489-h1n9ywbd	6	6	the	the	DT
cord-264489-h1n9ywbd	6	7	IL-18α	IL-18α	NNP
cord-264489-h1n9ywbd	6	8	receptor	receptor	NN
cord-264489-h1n9ywbd	6	9	and	and	CC
cord-264489-h1n9ywbd	6	10	forms	form	VBZ
cord-264489-h1n9ywbd	6	11	a	a	DT
cord-264489-h1n9ywbd	6	12	lower	low	JJR
cord-264489-h1n9ywbd	6	13	affinity	affinity	NN
cord-264489-h1n9ywbd	6	14	complex	complex	NN
cord-264489-h1n9ywbd	6	15	.	.	.
cord-264489-h1n9ywbd	7	1	Upon	upon	IN
cord-264489-h1n9ywbd	7	2	binding	bind	VBG
cord-264489-h1n9ywbd	7	3	with	with	IN
cord-264489-h1n9ywbd	7	4	IL-18β	IL-18β	NNP
cord-264489-h1n9ywbd	7	5	a	a	DT
cord-264489-h1n9ywbd	7	6	hetero	hetero	JJ
cord-264489-h1n9ywbd	7	7	-	-	JJ
cord-264489-h1n9ywbd	7	8	trimeric	trimeric	JJ
cord-264489-h1n9ywbd	7	9	complex	complex	NN
cord-264489-h1n9ywbd	7	10	with	with	IN
cord-264489-h1n9ywbd	7	11	higher	high	JJR
cord-264489-h1n9ywbd	7	12	affinity	affinity	NN
cord-264489-h1n9ywbd	7	13	is	be	VBZ
cord-264489-h1n9ywbd	7	14	formed	form	VBN
cord-264489-h1n9ywbd	7	15	that	that	WDT
cord-264489-h1n9ywbd	7	16	initiates	initiate	VBZ
cord-264489-h1n9ywbd	7	17	the	the	DT
cord-264489-h1n9ywbd	7	18	signal	signal	NN
cord-264489-h1n9ywbd	7	19	transduction	transduction	NN
cord-264489-h1n9ywbd	7	20	process	process	NN
cord-264489-h1n9ywbd	7	21	.	.	.
cord-264489-h1n9ywbd	8	1	The	the	DT
cord-264489-h1n9ywbd	8	2	present	present	JJ
cord-264489-h1n9ywbd	8	3	study	study	NN
cord-264489-h1n9ywbd	8	4	,	,	,
cord-264489-h1n9ywbd	8	5	including	include	VBG
cord-264489-h1n9ywbd	8	6	structural	structural	JJ
cord-264489-h1n9ywbd	8	7	and	and	CC
cord-264489-h1n9ywbd	8	8	molecular	molecular	JJ
cord-264489-h1n9ywbd	8	9	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	8	10	simulations	simulation	NNS
cord-264489-h1n9ywbd	8	11	,	,	,
cord-264489-h1n9ywbd	8	12	takes	take	VBZ
cord-264489-h1n9ywbd	8	13	a	a	DT
cord-264489-h1n9ywbd	8	14	close	close	JJ
cord-264489-h1n9ywbd	8	15	look	look	NN
cord-264489-h1n9ywbd	8	16	at	at	IN
cord-264489-h1n9ywbd	8	17	the	the	DT
cord-264489-h1n9ywbd	8	18	structural	structural	JJ
cord-264489-h1n9ywbd	8	19	stabilities	stability	NNS
cord-264489-h1n9ywbd	8	20	of	of	IN
cord-264489-h1n9ywbd	8	21	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	8	22	and	and	CC
cord-264489-h1n9ywbd	8	23	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	8	24	receptor	receptor	NN
cord-264489-h1n9ywbd	8	25	-	-	HYPH
cord-264489-h1n9ywbd	8	26	bound	bind	VBN
cord-264489-h1n9ywbd	8	27	ligand	ligand	NN
cord-264489-h1n9ywbd	8	28	structures	structure	NNS
cord-264489-h1n9ywbd	8	29	as	as	IN
cord-264489-h1n9ywbd	8	30	functions	function	NNS
cord-264489-h1n9ywbd	8	31	of	of	IN
cord-264489-h1n9ywbd	8	32	time	time	NN
cord-264489-h1n9ywbd	8	33	.	.	.
cord-264489-h1n9ywbd	9	1	The	the	DT
cord-264489-h1n9ywbd	9	2	results	result	NNS
cord-264489-h1n9ywbd	9	3	help	help	VBP
cord-264489-h1n9ywbd	9	4	to	to	TO
cord-264489-h1n9ywbd	9	5	identify	identify	VB
cord-264489-h1n9ywbd	9	6	the	the	DT
cord-264489-h1n9ywbd	9	7	conformational	conformational	JJ
cord-264489-h1n9ywbd	9	8	changes	change	NNS
cord-264489-h1n9ywbd	9	9	of	of	IN
cord-264489-h1n9ywbd	9	10	the	the	DT
cord-264489-h1n9ywbd	9	11	ligand	ligand	NN
cord-264489-h1n9ywbd	9	12	due	due	IN
cord-264489-h1n9ywbd	9	13	to	to	IN
cord-264489-h1n9ywbd	9	14	receptor	receptor	NN
cord-264489-h1n9ywbd	9	15	binding	binding	NN
cord-264489-h1n9ywbd	9	16	,	,	,
cord-264489-h1n9ywbd	9	17	as	as	RB
cord-264489-h1n9ywbd	9	18	well	well	RB
cord-264489-h1n9ywbd	9	19	as	as	IN
cord-264489-h1n9ywbd	9	20	the	the	DT
cord-264489-h1n9ywbd	9	21	structural	structural	JJ
cord-264489-h1n9ywbd	9	22	orders	order	NNS
cord-264489-h1n9ywbd	9	23	of	of	IN
cord-264489-h1n9ywbd	9	24	the	the	DT
cord-264489-h1n9ywbd	9	25	apo	apo	NNP
cord-264489-h1n9ywbd	9	26	and	and	CC
cord-264489-h1n9ywbd	9	27	holo	holo	NNP
cord-264489-h1n9ywbd	9	28	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	9	29	protein	protein	NN
cord-264489-h1n9ywbd	9	30	complexes	complex	NNS
cord-264489-h1n9ywbd	9	31	.	.	.
cord-264489-h1n9ywbd	10	1	Immunologically	immunologically	RB
cord-264489-h1n9ywbd	10	2	relevant	relevant	JJ
cord-264489-h1n9ywbd	10	3	proteins	protein	NNS
cord-264489-h1n9ywbd	10	4	are	be	VBP
cord-264489-h1n9ywbd	10	5	critical	critical	JJ
cord-264489-h1n9ywbd	10	6	for	for	IN
cord-264489-h1n9ywbd	10	7	the	the	DT
cord-264489-h1n9ywbd	10	8	functioning	functioning	NN
cord-264489-h1n9ywbd	10	9	of	of	IN
cord-264489-h1n9ywbd	10	10	cellular	cellular	JJ
cord-264489-h1n9ywbd	10	11	pathways	pathway	NNS
cord-264489-h1n9ywbd	10	12	.	.	.
cord-264489-h1n9ywbd	11	1	Therefore	therefore	RB
cord-264489-h1n9ywbd	11	2	,	,	,
cord-264489-h1n9ywbd	11	3	in	in	IN
cord-264489-h1n9ywbd	11	4	the	the	DT
cord-264489-h1n9ywbd	11	5	general	general	JJ
cord-264489-h1n9ywbd	11	6	contexts	context	NNS
cord-264489-h1n9ywbd	11	7	of	of	IN
cord-264489-h1n9ywbd	11	8	target	target	NN
cord-264489-h1n9ywbd	11	9	-	-	HYPH
cord-264489-h1n9ywbd	11	10	based	base	VBN
cord-264489-h1n9ywbd	11	11	therapies	therapy	NNS
cord-264489-h1n9ywbd	11	12	and	and	CC
cord-264489-h1n9ywbd	11	13	drug	drug	NN
cord-264489-h1n9ywbd	11	14	designs	design	NNS
cord-264489-h1n9ywbd	11	15	,	,	,
cord-264489-h1n9ywbd	11	16	it	-PRON-	PRP
cord-264489-h1n9ywbd	11	17	is	be	VBZ
cord-264489-h1n9ywbd	11	18	necessary	necessary	JJ
cord-264489-h1n9ywbd	11	19	to	to	TO
cord-264489-h1n9ywbd	11	20	fully	fully	RB
cord-264489-h1n9ywbd	11	21	understand	understand	VB
cord-264489-h1n9ywbd	11	22	how	how	WRB
cord-264489-h1n9ywbd	11	23	these	these	DT
cord-264489-h1n9ywbd	11	24	proteins	protein	NNS
cord-264489-h1n9ywbd	11	25	and	and	CC
cord-264489-h1n9ywbd	11	26	their	-PRON-	PRP$
cord-264489-h1n9ywbd	11	27	variants	variant	NNS
cord-264489-h1n9ywbd	11	28	participate	participate	VBP
cord-264489-h1n9ywbd	11	29	in	in	IN
cord-264489-h1n9ywbd	11	30	the	the	DT
cord-264489-h1n9ywbd	11	31	progressions	progression	NNS
cord-264489-h1n9ywbd	11	32	of	of	IN
cord-264489-h1n9ywbd	11	33	inflammatory	inflammatory	JJ
cord-264489-h1n9ywbd	11	34	,	,	,
cord-264489-h1n9ywbd	11	35	autoimmune	autoimmune	JJ
cord-264489-h1n9ywbd	11	36	and	and	CC
cord-264489-h1n9ywbd	11	37	infectious	infectious	JJ
cord-264489-h1n9ywbd	11	38	human	human	JJ
cord-264489-h1n9ywbd	11	39	diseases	disease	NNS
cord-264489-h1n9ywbd	11	40	(	(	-LRB-
cord-264489-h1n9ywbd	11	41	Kabat	Kabat	NNP
cord-264489-h1n9ywbd	11	42	1968	1968	CD
cord-264489-h1n9ywbd	11	43	;	;	:
cord-264489-h1n9ywbd	12	1	Voit	Voit	NNP
cord-264489-h1n9ywbd	12	2	2014	2014	CD
cord-264489-h1n9ywbd	12	3	;	;	:
cord-264489-h1n9ywbd	12	4	Taylor	Taylor	NNP
cord-264489-h1n9ywbd	12	5	et	et	NNP
cord-264489-h1n9ywbd	12	6	al	al	NNP
cord-264489-h1n9ywbd	12	7	.	.	.
cord-264489-h1n9ywbd	12	8	2017	2017	CD
cord-264489-h1n9ywbd	13	1	;	;	:
cord-264489-h1n9ywbd	13	2	Gupta	Gupta	NNP
cord-264489-h1n9ywbd	13	3	et	et	NNP
cord-264489-h1n9ywbd	13	4	al	al	NNP
cord-264489-h1n9ywbd	13	5	.	.	.
cord-264489-h1n9ywbd	14	1	2019	2019	CD
cord-264489-h1n9ywbd	14	2	;	;	:
cord-264489-h1n9ywbd	14	3	Huang	Huang	NNP
cord-264489-h1n9ywbd	14	4	et	et	NNP
cord-264489-h1n9ywbd	14	5	al	al	NNP
cord-264489-h1n9ywbd	14	6	.	.	.
cord-264489-h1n9ywbd	15	1	2019	2019	CD
cord-264489-h1n9ywbd	15	2	;	;	:
cord-264489-h1n9ywbd	15	3	Jang	Jang	NNP
cord-264489-h1n9ywbd	15	4	et	et	FW
cord-264489-h1n9ywbd	15	5	al	al	NNP
cord-264489-h1n9ywbd	15	6	.	.	.
cord-264489-h1n9ywbd	15	7	2019	2019	CD
cord-264489-h1n9ywbd	15	8	)	)	-RRB-
cord-264489-h1n9ywbd	15	9	.	.	.
cord-264489-h1n9ywbd	16	1	The	the	DT
cord-264489-h1n9ywbd	16	2	task	task	NN
cord-264489-h1n9ywbd	16	3	of	of	IN
cord-264489-h1n9ywbd	16	4	gathering	gather	VBG
cord-264489-h1n9ywbd	16	5	detailed	detailed	JJ
cord-264489-h1n9ywbd	16	6	knowledge	knowledge	NN
cord-264489-h1n9ywbd	16	7	about	about	IN
cord-264489-h1n9ywbd	16	8	this	this	DT
cord-264489-h1n9ywbd	16	9	topic	topic	NN
cord-264489-h1n9ywbd	16	10	can	can	MD
cord-264489-h1n9ywbd	16	11	be	be	VB
cord-264489-h1n9ywbd	16	12	aided	aid	VBN
cord-264489-h1n9ywbd	16	13	to	to	IN
cord-264489-h1n9ywbd	16	14	a	a	DT
cord-264489-h1n9ywbd	16	15	large	large	JJ
cord-264489-h1n9ywbd	16	16	extent	extent	NN
cord-264489-h1n9ywbd	16	17	with	with	IN
cord-264489-h1n9ywbd	16	18	residue	residue	NN
cord-264489-h1n9ywbd	16	19	-	-	HYPH
cord-264489-h1n9ywbd	16	20	level	level	NN
cord-264489-h1n9ywbd	16	21	structural	structural	JJ
cord-264489-h1n9ywbd	16	22	analyses	analysis	NNS
cord-264489-h1n9ywbd	16	23	of	of	IN
cord-264489-h1n9ywbd	16	24	immunologically	immunologically	RB
cord-264489-h1n9ywbd	16	25	significant	significant	JJ
cord-264489-h1n9ywbd	16	26	proteins	protein	NNS
cord-264489-h1n9ywbd	16	27	and	and	CC
cord-264489-h1n9ywbd	16	28	their	-PRON-	PRP$
cord-264489-h1n9ywbd	16	29	interaction	interaction	NN
cord-264489-h1n9ywbd	16	30	with	with	IN
cord-264489-h1n9ywbd	16	31	receptors	receptor	NNS
cord-264489-h1n9ywbd	16	32	(	(	-LRB-
cord-264489-h1n9ywbd	16	33	Moczydlowski	Moczydlowski	NNP
cord-264489-h1n9ywbd	16	34	2013	2013	CD
cord-264489-h1n9ywbd	16	35	;	;	:
cord-264489-h1n9ywbd	16	36	Xiao	Xiao	NNP
cord-264489-h1n9ywbd	16	37	et	et	NNP
cord-264489-h1n9ywbd	16	38	al	al	NNP
cord-264489-h1n9ywbd	16	39	.	.	.
cord-264489-h1n9ywbd	16	40	2018	2018	CD
cord-264489-h1n9ywbd	16	41	;	;	:
cord-264489-h1n9ywbd	16	42	Yao	Yao	NNP
cord-264489-h1n9ywbd	16	43	et	et	NNP
cord-264489-h1n9ywbd	16	44	al	al	NNP
cord-264489-h1n9ywbd	16	45	.	.	.
cord-264489-h1n9ywbd	16	46	2019	2019	CD
cord-264489-h1n9ywbd	16	47	)	)	-RRB-
cord-264489-h1n9ywbd	16	48	.	.	.
cord-264489-h1n9ywbd	17	1	This	this	DT
cord-264489-h1n9ywbd	17	2	investigative	investigative	JJ
cord-264489-h1n9ywbd	17	3	approach	approach	NN
cord-264489-h1n9ywbd	17	4	assists	assist	VBZ
cord-264489-h1n9ywbd	17	5	in	in	IN
cord-264489-h1n9ywbd	17	6	the	the	DT
cord-264489-h1n9ywbd	17	7	proper	proper	JJ
cord-264489-h1n9ywbd	17	8	identifications	identification	NNS
cord-264489-h1n9ywbd	17	9	of	of	IN
cord-264489-h1n9ywbd	17	10	therapeutic	therapeutic	JJ
cord-264489-h1n9ywbd	17	11	-	-	HYPH
cord-264489-h1n9ywbd	17	12	targets	target	NNS
cord-264489-h1n9ywbd	17	13	,	,	,
cord-264489-h1n9ywbd	17	14	their	-PRON-	PRP$
cord-264489-h1n9ywbd	17	15	structural	structural	JJ
cord-264489-h1n9ywbd	17	16	-	-	HYPH
cord-264489-h1n9ywbd	17	17	assemblies	assembly	NNS
cord-264489-h1n9ywbd	17	18	and	and	CC
cord-264489-h1n9ywbd	17	19	consistent	consistent	JJ
cord-264489-h1n9ywbd	17	20	ligand	ligand	NN
cord-264489-h1n9ywbd	17	21	-	-	HYPH
cord-264489-h1n9ywbd	17	22	receptor	receptor	NN
cord-264489-h1n9ywbd	17	23	interfacial	interfacial	JJ
cord-264489-h1n9ywbd	17	24	interactions	interaction	NNS
cord-264489-h1n9ywbd	17	25	,	,	,
cord-264489-h1n9ywbd	17	26	and	and	CC
cord-264489-h1n9ywbd	17	27	thus	thus	RB
cord-264489-h1n9ywbd	17	28	,	,	,
cord-264489-h1n9ywbd	17	29	plays	play	VBZ
cord-264489-h1n9ywbd	17	30	a	a	DT
cord-264489-h1n9ywbd	17	31	vital	vital	JJ
cord-264489-h1n9ywbd	17	32	role	role	NN
cord-264489-h1n9ywbd	17	33	in	in	IN
cord-264489-h1n9ywbd	17	34	the	the	DT
cord-264489-h1n9ywbd	17	35	development	development	NN
cord-264489-h1n9ywbd	17	36	of	of	IN
cord-264489-h1n9ywbd	17	37	new	new	JJ
cord-264489-h1n9ywbd	17	38	,	,	,
cord-264489-h1n9ywbd	17	39	innovative	innovative	JJ
cord-264489-h1n9ywbd	17	40	medicines	medicine	NNS
cord-264489-h1n9ywbd	17	41	(	(	-LRB-
cord-264489-h1n9ywbd	17	42	Freudenberg	Freudenberg	NNP
cord-264489-h1n9ywbd	17	43	et	et	FW
cord-264489-h1n9ywbd	17	44	al	al	NNP
cord-264489-h1n9ywbd	17	45	.	.	.
cord-264489-h1n9ywbd	17	46	2002	2002	CD
cord-264489-h1n9ywbd	17	47	;	;	:
cord-264489-h1n9ywbd	17	48	Asbury	Asbury	NNP
cord-264489-h1n9ywbd	17	49	et	et	NNP
cord-264489-h1n9ywbd	17	50	al	al	NNP
cord-264489-h1n9ywbd	17	51	.	.	NNP
cord-264489-h1n9ywbd	17	52	2010	2010	CD
cord-264489-h1n9ywbd	17	53	;	;	:
cord-264489-h1n9ywbd	17	54	Haydarlou	Haydarlou	NNP
cord-264489-h1n9ywbd	17	55	et	et	NNP
cord-264489-h1n9ywbd	17	56	al	al	NNP
cord-264489-h1n9ywbd	17	57	.	.	.
cord-264489-h1n9ywbd	17	58	2016	2016	CD
cord-264489-h1n9ywbd	17	59	;	;	:
cord-264489-h1n9ywbd	17	60	Mariethoz	Mariethoz	NNP
cord-264489-h1n9ywbd	17	61	et	et	NNP
cord-264489-h1n9ywbd	17	62	al	al	NNP
cord-264489-h1n9ywbd	17	63	.	.	.
cord-264489-h1n9ywbd	17	64	2016	2016	CD
cord-264489-h1n9ywbd	17	65	;	;	:
cord-264489-h1n9ywbd	17	66	Janwa	Janwa	NNP
cord-264489-h1n9ywbd	17	67	et	et	NNP
cord-264489-h1n9ywbd	17	68	al	al	NNP
cord-264489-h1n9ywbd	17	69	.	.	.
cord-264489-h1n9ywbd	17	70	2019	2019	CD
cord-264489-h1n9ywbd	17	71	)	)	-RRB-
cord-264489-h1n9ywbd	17	72	.	.	.
cord-264489-h1n9ywbd	18	1	The	the	DT
cord-264489-h1n9ywbd	18	2	present	present	JJ
cord-264489-h1n9ywbd	18	3	study	study	NN
cord-264489-h1n9ywbd	18	4	of	of	IN
cord-264489-h1n9ywbd	18	5	molecular	molecular	JJ
cord-264489-h1n9ywbd	18	6	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	18	7	(	(	-LRB-
cord-264489-h1n9ywbd	18	8	MD	MD	NNP
cord-264489-h1n9ywbd	18	9	)	)	-RRB-
cord-264489-h1n9ywbd	18	10	simulation	simulation	NN
cord-264489-h1n9ywbd	18	11	(	(	-LRB-
cord-264489-h1n9ywbd	18	12	Ho	Ho	NNP
cord-264489-h1n9ywbd	18	13	and	and	CC
cord-264489-h1n9ywbd	18	14	Hamelberg	Hamelberg	NNP
cord-264489-h1n9ywbd	18	15	2018	2018	CD
cord-264489-h1n9ywbd	18	16	;	;	:
cord-264489-h1n9ywbd	18	17	Jin	Jin	NNP
cord-264489-h1n9ywbd	18	18	et	et	NNP
cord-264489-h1n9ywbd	18	19	al	al	NNP
cord-264489-h1n9ywbd	18	20	.	.	.
cord-264489-h1n9ywbd	18	21	2020	2020	CD
cord-264489-h1n9ywbd	18	22	;	;	:
cord-264489-h1n9ywbd	18	23	Weako	Weako	NNP
cord-264489-h1n9ywbd	18	24	et	et	FW
cord-264489-h1n9ywbd	18	25	al	al	NNP
cord-264489-h1n9ywbd	18	26	.	.	NNP
cord-264489-h1n9ywbd	18	27	2020	2020	CD
cord-264489-h1n9ywbd	18	28	)	)	-RRB-
cord-264489-h1n9ywbd	18	29	,	,	,
cord-264489-h1n9ywbd	18	30	focusing	focus	VBG
cord-264489-h1n9ywbd	18	31	on	on	IN
cord-264489-h1n9ywbd	18	32	Interleukin-18	interleukin-18	NN
cord-264489-h1n9ywbd	18	33	(	(	-LRB-
cord-264489-h1n9ywbd	18	34	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	18	35	)	)	-RRB-
cord-264489-h1n9ywbd	18	36	,	,	,
cord-264489-h1n9ywbd	18	37	falls	fall	VBZ
cord-264489-h1n9ywbd	18	38	in	in	IN
cord-264489-h1n9ywbd	18	39	this	this	DT
cord-264489-h1n9ywbd	18	40	category	category	NN
cord-264489-h1n9ywbd	18	41	of	of	IN
cord-264489-h1n9ywbd	18	42	computational	computational	JJ
cord-264489-h1n9ywbd	18	43	structural	structural	JJ
cord-264489-h1n9ywbd	18	44	immunology	immunology	NN
cord-264489-h1n9ywbd	18	45	.	.	.
cord-264489-h1n9ywbd	19	1	The	the	DT
cord-264489-h1n9ywbd	19	2	main	main	JJ
cord-264489-h1n9ywbd	19	3	goal	goal	NN
cord-264489-h1n9ywbd	19	4	of	of	IN
cord-264489-h1n9ywbd	19	5	this	this	DT
cord-264489-h1n9ywbd	19	6	study	study	NN
cord-264489-h1n9ywbd	19	7	is	be	VBZ
cord-264489-h1n9ywbd	19	8	to	to	TO
cord-264489-h1n9ywbd	19	9	explore	explore	VB
cord-264489-h1n9ywbd	19	10	the	the	DT
cord-264489-h1n9ywbd	19	11	essential	essential	JJ
cord-264489-h1n9ywbd	19	12	structural	structural	JJ
cord-264489-h1n9ywbd	19	13	and	and	CC
cord-264489-h1n9ywbd	19	14	conformational	conformational	JJ
cord-264489-h1n9ywbd	19	15	aspects	aspect	NNS
cord-264489-h1n9ywbd	19	16	of	of	IN
cord-264489-h1n9ywbd	19	17	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	19	18	ligand	ligand	NN
cord-264489-h1n9ywbd	19	19	and	and	CC
cord-264489-h1n9ywbd	19	20	ligand	ligand	NN
cord-264489-h1n9ywbd	19	21	bound	bind	VBN
cord-264489-h1n9ywbd	19	22	receptor	receptor	NN
cord-264489-h1n9ywbd	19	23	systems	system	NNS
cord-264489-h1n9ywbd	19	24	.	.	.
cord-264489-h1n9ywbd	20	1	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	20	2	,	,	,
cord-264489-h1n9ywbd	20	3	also	also	RB
cord-264489-h1n9ywbd	20	4	known	know	VBN
cord-264489-h1n9ywbd	20	5	as	as	IN
cord-264489-h1n9ywbd	20	6	interferon	interferon	NN
cord-264489-h1n9ywbd	20	7	gamma	gamma	NN
cord-264489-h1n9ywbd	20	8	(	(	-LRB-
cord-264489-h1n9ywbd	20	9	IFN-	IFN-	NNP
cord-264489-h1n9ywbd	20	10	)	)	-RRB-
cord-264489-h1n9ywbd	20	11	inducing	induce	VBG
cord-264489-h1n9ywbd	20	12	factor	factor	NN
cord-264489-h1n9ywbd	20	13	,	,	,
cord-264489-h1n9ywbd	20	14	is	be	VBZ
cord-264489-h1n9ywbd	20	15	a	a	DT
cord-264489-h1n9ywbd	20	16	pro	pro	JJ
cord-264489-h1n9ywbd	20	17	-	-	JJ
cord-264489-h1n9ywbd	20	18	inflammatory	inflammatory	JJ
cord-264489-h1n9ywbd	20	19	cytokine	cytokine	NN
cord-264489-h1n9ywbd	20	20	.	.	.
cord-264489-h1n9ywbd	21	1	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	21	2	induces	induce	VBZ
cord-264489-h1n9ywbd	21	3	T	T	NNP
cord-264489-h1n9ywbd	21	4	helper	helper	NN
cord-264489-h1n9ywbd	21	5	(	(	-LRB-
cord-264489-h1n9ywbd	21	6	TH	TH	NNP
cord-264489-h1n9ywbd	21	7	)	)	-RRB-
cord-264489-h1n9ywbd	21	8	cells	cell	NNS
cord-264489-h1n9ywbd	21	9	1	1	CD
cord-264489-h1n9ywbd	21	10	and	and	CC
cord-264489-h1n9ywbd	21	11	2	2	CD
cord-264489-h1n9ywbd	21	12	responses	response	NNS
cord-264489-h1n9ywbd	21	13	,	,	,
cord-264489-h1n9ywbd	21	14	and	and	CC
cord-264489-h1n9ywbd	21	15	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	21	16	signal	signal	NN
cord-264489-h1n9ywbd	21	17	transduction	transduction	NN
cord-264489-h1n9ywbd	22	1	J	J	NNP
cord-264489-h1n9ywbd	22	2	o	o	NN
cord-264489-h1n9ywbd	22	3	u	u	NN
cord-264489-h1n9ywbd	22	4	r	r	NN
cord-264489-h1n9ywbd	22	5	n	n	NN
cord-264489-h1n9ywbd	22	6	a	a	DT
cord-264489-h1n9ywbd	22	7	l	l	NN
cord-264489-h1n9ywbd	22	8	P	p	NN
cord-264489-h1n9ywbd	22	9	r	r	NN
cord-264489-h1n9ywbd	22	10	e	e	NN
cord-264489-h1n9ywbd	23	1	-p	-p	NNP
cord-264489-h1n9ywbd	23	2	r	r	NN
cord-264489-h1n9ywbd	23	3	o	o	NN
cord-264489-h1n9ywbd	23	4	o	o	NN
cord-264489-h1n9ywbd	23	5	f	f	NN
cord-264489-h1n9ywbd	23	6	cascade	cascade	NN
cord-264489-h1n9ywbd	23	7	can	can	MD
cord-264489-h1n9ywbd	23	8	also	also	RB
cord-264489-h1n9ywbd	23	9	activate	activate	VB
cord-264489-h1n9ywbd	23	10	nuclear	nuclear	JJ
cord-264489-h1n9ywbd	23	11	factor	factor	NN
cord-264489-h1n9ywbd	23	12	kappa	kappa	NN
cord-264489-h1n9ywbd	23	13	beta	beta	NN
cord-264489-h1n9ywbd	23	14	(	(	-LRB-
cord-264489-h1n9ywbd	23	15	NF	nf	NN
cord-264489-h1n9ywbd	23	16	)	)	-RRB-
cord-264489-h1n9ywbd	24	1	(	(	-LRB-
cord-264489-h1n9ywbd	24	2	Mak	Mak	NNP
cord-264489-h1n9ywbd	24	3	and	and	CC
cord-264489-h1n9ywbd	24	4	Saunders	Saunders	NNP
cord-264489-h1n9ywbd	24	5	2006	2006	CD
cord-264489-h1n9ywbd	24	6	)	)	-RRB-
cord-264489-h1n9ywbd	24	7	.	.	.
cord-264489-h1n9ywbd	25	1	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	25	2	,	,	,
cord-264489-h1n9ywbd	25	3	a	a	DT
cord-264489-h1n9ywbd	25	4	member	member	NN
cord-264489-h1n9ywbd	25	5	of	of	IN
cord-264489-h1n9ywbd	25	6	interleukin-1	interleukin-1	NNP
cord-264489-h1n9ywbd	25	7	(	(	-LRB-
cord-264489-h1n9ywbd	25	8	IL-1	IL-1	NNP
cord-264489-h1n9ywbd	25	9	)	)	-RRB-
cord-264489-h1n9ywbd	25	10	family	family	NN
cord-264489-h1n9ywbd	25	11	,	,	,
cord-264489-h1n9ywbd	25	12	is	be	VBZ
cord-264489-h1n9ywbd	25	13	similar	similar	JJ
cord-264489-h1n9ywbd	25	14	to	to	IN
cord-264489-h1n9ywbd	25	15	interleukin-12	interleukin-12	NNP
cord-264489-h1n9ywbd	25	16	,	,	,
cord-264489-h1n9ywbd	25	17	and	and	CC
cord-264489-h1n9ywbd	25	18	is	be	VBZ
cord-264489-h1n9ywbd	25	19	important	important	JJ
cord-264489-h1n9ywbd	25	20	for	for	IN
cord-264489-h1n9ywbd	25	21	supporting	support	VBG
cord-264489-h1n9ywbd	25	22	the	the	DT
cord-264489-h1n9ywbd	25	23	host	host	NN
cord-264489-h1n9ywbd	25	24	defense	defense	NN
cord-264489-h1n9ywbd	25	25	(	(	-LRB-
cord-264489-h1n9ywbd	25	26	Dinarello	Dinarello	NNP
cord-264489-h1n9ywbd	25	27	1999	1999	CD
cord-264489-h1n9ywbd	25	28	;	;	:
cord-264489-h1n9ywbd	26	1	Gracie	Gracie	NNP
cord-264489-h1n9ywbd	26	2	et	et	NNP
cord-264489-h1n9ywbd	26	3	al	al	NNP
cord-264489-h1n9ywbd	26	4	.	.	NNP
cord-264489-h1n9ywbd	26	5	2003	2003	CD
cord-264489-h1n9ywbd	26	6	)	)	-RRB-
cord-264489-h1n9ywbd	26	7	.	.	.
cord-264489-h1n9ywbd	27	1	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	27	2	bridges	bridge	VBZ
cord-264489-h1n9ywbd	27	3	the	the	DT
cord-264489-h1n9ywbd	27	4	gap	gap	NN
cord-264489-h1n9ywbd	27	5	between	between	IN
cord-264489-h1n9ywbd	27	6	innate	innate	JJ
cord-264489-h1n9ywbd	27	7	and	and	CC
cord-264489-h1n9ywbd	27	8	adaptive	adaptive	JJ
cord-264489-h1n9ywbd	27	9	immune	immune	JJ
cord-264489-h1n9ywbd	27	10	responses	response	NNS
cord-264489-h1n9ywbd	27	11	and	and	CC
cord-264489-h1n9ywbd	27	12	is	be	VBZ
cord-264489-h1n9ywbd	27	13	responsible	responsible	JJ
cord-264489-h1n9ywbd	27	14	for	for	IN
cord-264489-h1n9ywbd	27	15	various	various	JJ
cord-264489-h1n9ywbd	27	16	inflammatory	inflammatory	JJ
cord-264489-h1n9ywbd	27	17	,	,	,
cord-264489-h1n9ywbd	27	18	autoimmune	autoimmune	JJ
cord-264489-h1n9ywbd	27	19	and	and	CC
cord-264489-h1n9ywbd	27	20	physiological	physiological	JJ
cord-264489-h1n9ywbd	27	21	conditions	condition	NNS
cord-264489-h1n9ywbd	27	22	,	,	,
cord-264489-h1n9ywbd	27	23	such	such	JJ
cord-264489-h1n9ywbd	27	24	as	as	IN
cord-264489-h1n9ywbd	27	25	inflammatory	inflammatory	JJ
cord-264489-h1n9ywbd	27	26	bowel	bowel	NN
cord-264489-h1n9ywbd	27	27	disease	disease	NN
cord-264489-h1n9ywbd	27	28	,	,	,
cord-264489-h1n9ywbd	27	29	psoriasis	psoriasis	NN
cord-264489-h1n9ywbd	27	30	,	,	,
cord-264489-h1n9ywbd	27	31	sepsis	sepsis	NN
cord-264489-h1n9ywbd	27	32	,	,	,
cord-264489-h1n9ywbd	27	33	myocardial	myocardial	JJ
cord-264489-h1n9ywbd	27	34	infarction	infarction	NN
cord-264489-h1n9ywbd	27	35	,	,	,
cord-264489-h1n9ywbd	27	36	Crohn	Crohn	NNP
cord-264489-h1n9ywbd	27	37	's	's	POS
cord-264489-h1n9ywbd	27	38	disease	disease	NN
cord-264489-h1n9ywbd	27	39	,	,	,
cord-264489-h1n9ywbd	27	40	arthritis	arthritis	NN
cord-264489-h1n9ywbd	27	41	and	and	CC
cord-264489-h1n9ywbd	27	42	cancer	cancer	NN
cord-264489-h1n9ywbd	27	43	.	.	.
cord-264489-h1n9ywbd	28	1	The	the	DT
cord-264489-h1n9ywbd	28	2	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	28	3	first	first	RB
cord-264489-h1n9ywbd	28	4	binds	bind	VBZ
cord-264489-h1n9ywbd	28	5	to	to	IN
cord-264489-h1n9ywbd	28	6	the	the	DT
cord-264489-h1n9ywbd	28	7	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	28	8	receptor	receptor	NN
cord-264489-h1n9ywbd	28	9	(	(	-LRB-
cord-264489-h1n9ywbd	28	10	IL-18R	IL-18R	NNP
cord-264489-h1n9ywbd	28	11	and	and	CC
cord-264489-h1n9ywbd	28	12	forms	form	VBZ
cord-264489-h1n9ywbd	28	13	a	a	DT
cord-264489-h1n9ywbd	28	14	lower	low	JJR
cord-264489-h1n9ywbd	28	15	affinity	affinity	NN
cord-264489-h1n9ywbd	28	16	complex	complex	NN
cord-264489-h1n9ywbd	28	17	.	.	.
cord-264489-h1n9ywbd	29	1	Upon	upon	IN
cord-264489-h1n9ywbd	29	2	binding	bind	VBG
cord-264489-h1n9ywbd	29	3	with	with	IN
cord-264489-h1n9ywbd	29	4	IL-18	il-18	JJ
cord-264489-h1n9ywbd	29	5	receptor	receptor	NN
cord-264489-h1n9ywbd	29	6	(	(	-LRB-
cord-264489-h1n9ywbd	29	7	IL-18Ra	IL-18Ra	VBN
cord-264489-h1n9ywbd	29	8	hetero	hetero	JJ
cord-264489-h1n9ywbd	29	9	-	-	JJ
cord-264489-h1n9ywbd	29	10	trimeric	trimeric	JJ
cord-264489-h1n9ywbd	29	11	complex	complex	NN
cord-264489-h1n9ywbd	29	12	with	with	IN
cord-264489-h1n9ywbd	29	13	higher	high	JJR
cord-264489-h1n9ywbd	29	14	affinity	affinity	NN
cord-264489-h1n9ywbd	29	15	is	be	VBZ
cord-264489-h1n9ywbd	29	16	formed	form	VBN
cord-264489-h1n9ywbd	29	17	,	,	,
cord-264489-h1n9ywbd	29	18	which	which	WDT
cord-264489-h1n9ywbd	29	19	initiates	initiate	VBZ
cord-264489-h1n9ywbd	29	20	the	the	DT
cord-264489-h1n9ywbd	29	21	signal	signal	NN
cord-264489-h1n9ywbd	29	22	transduction	transduction	NN
cord-264489-h1n9ywbd	29	23	process	process	NN
cord-264489-h1n9ywbd	29	24	and	and	CC
cord-264489-h1n9ywbd	29	25	,	,	,
cord-264489-h1n9ywbd	29	26	triggers	trigger	VBZ
cord-264489-h1n9ywbd	29	27	the	the	DT
cord-264489-h1n9ywbd	29	28	NF	NF	NNP
cord-264489-h1n9ywbd	29	29	-	-	HYPH
cord-264489-h1n9ywbd	29	30	κβ	κβ	NNP
cord-264489-h1n9ywbd	29	31	,	,	,
cord-264489-h1n9ywbd	29	32	leading	lead	VBG
cord-264489-h1n9ywbd	29	33	to	to	IN
cord-264489-h1n9ywbd	29	34	a	a	DT
cord-264489-h1n9ywbd	29	35	downstream	downstream	JJ
cord-264489-h1n9ywbd	29	36	transcription	transcription	NN
cord-264489-h1n9ywbd	29	37	through	through	IN
cord-264489-h1n9ywbd	29	38	mitogen	mitogen	NN
cord-264489-h1n9ywbd	29	39	-	-	HYPH
cord-264489-h1n9ywbd	29	40	activated	activate	VBN
cord-264489-h1n9ywbd	29	41	protein	protein	NN
cord-264489-h1n9ywbd	29	42	kinase	kinase	NN
cord-264489-h1n9ywbd	29	43	(	(	-LRB-
cord-264489-h1n9ywbd	29	44	MAPK	MAPK	NNP
cord-264489-h1n9ywbd	29	45	)	)	-RRB-
cord-264489-h1n9ywbd	29	46	signaling	signal	VBG
cord-264489-h1n9ywbd	29	47	cascades	cascade	NNS
cord-264489-h1n9ywbd	30	1	(	(	-LRB-
cord-264489-h1n9ywbd	30	2	Kato	Kato	NNP
cord-264489-h1n9ywbd	30	3	et	et	NNP
cord-264489-h1n9ywbd	30	4	al	al	NNP
cord-264489-h1n9ywbd	30	5	.	.	.
cord-264489-h1n9ywbd	31	1	2003	2003	CD
cord-264489-h1n9ywbd	31	2	;	;	:
cord-264489-h1n9ywbd	31	3	Ohnishi	Ohnishi	NNP
cord-264489-h1n9ywbd	31	4	et	et	NNP
cord-264489-h1n9ywbd	31	5	al	al	NNP
cord-264489-h1n9ywbd	31	6	.	.	.
cord-264489-h1n9ywbd	32	1	2012	2012	CD
cord-264489-h1n9ywbd	32	2	;	;	:
cord-264489-h1n9ywbd	32	3	Tsutsumi	Tsutsumi	NNP
cord-264489-h1n9ywbd	32	4	et	et	NNP
cord-264489-h1n9ywbd	32	5	al	al	NNP
cord-264489-h1n9ywbd	32	6	.	.	NNP
cord-264489-h1n9ywbd	32	7	2014	2014	CD
cord-264489-h1n9ywbd	32	8	)	)	-RRB-
cord-264489-h1n9ywbd	32	9	.	.	.
cord-264489-h1n9ywbd	33	1	As	as	IN
cord-264489-h1n9ywbd	33	2	reported	report	VBN
cord-264489-h1n9ywbd	33	3	by	by	IN
cord-264489-h1n9ywbd	33	4	previous	previous	JJ
cord-264489-h1n9ywbd	33	5	authors	author	NNS
cord-264489-h1n9ywbd	33	6	,	,	,
cord-264489-h1n9ywbd	33	7	IL-1Rrp	IL-1Rrp	NNP
cord-264489-h1n9ywbd	33	8	,	,	,
cord-264489-h1n9ywbd	33	9	the	the	DT
cord-264489-h1n9ywbd	33	10	main	main	JJ
cord-264489-h1n9ywbd	33	11	IL-18R	il-18r	NN
cord-264489-h1n9ywbd	33	12	,	,	,
cord-264489-h1n9ywbd	33	13	binds	bind	VBZ
cord-264489-h1n9ywbd	33	14	to	to	IN
cord-264489-h1n9ywbd	33	15	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	33	16	,	,	,
cord-264489-h1n9ywbd	33	17	but	but	CC
cord-264489-h1n9ywbd	33	18	not	not	RB
cord-264489-h1n9ywbd	33	19	to	to	IN
cord-264489-h1n9ywbd	34	1	IL-1β	IL-1β	NNP
cord-264489-h1n9ywbd	35	1	(	(	-LRB-
cord-264489-h1n9ywbd	35	2	Nakamura	Nakamura	NNP
cord-264489-h1n9ywbd	35	3	et	et	NNP
cord-264489-h1n9ywbd	35	4	al	al	NNP
cord-264489-h1n9ywbd	35	5	.	.	.
cord-264489-h1n9ywbd	35	6	2000	2000	CD
cord-264489-h1n9ywbd	35	7	)	)	-RRB-
cord-264489-h1n9ywbd	35	8	.	.	.
cord-264489-h1n9ywbd	36	1	Kato	Kato	NNP
cord-264489-h1n9ywbd	36	2	et	et	NNP
cord-264489-h1n9ywbd	36	3	al	al	NNP
cord-264489-h1n9ywbd	36	4	.	.	NNP
cord-264489-h1n9ywbd	36	5	have	have	VBP
cord-264489-h1n9ywbd	36	6	described	describe	VBN
cord-264489-h1n9ywbd	36	7	the	the	DT
cord-264489-h1n9ywbd	36	8	first	first	JJ
cord-264489-h1n9ywbd	36	9	solution	solution	NN
cord-264489-h1n9ywbd	36	10	structure	structure	NN
cord-264489-h1n9ywbd	36	11	of	of	IN
cord-264489-h1n9ywbd	36	12	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	36	13	ligand	ligand	NN
cord-264489-h1n9ywbd	36	14	(	(	-LRB-
cord-264489-h1n9ywbd	36	15	Kato	Kato	NNP
cord-264489-h1n9ywbd	36	16	et	et	NNP
cord-264489-h1n9ywbd	36	17	al	al	NNP
cord-264489-h1n9ywbd	36	18	.	.	NNP
cord-264489-h1n9ywbd	36	19	2003	2003	CD
cord-264489-h1n9ywbd	36	20	)	)	-RRB-
cord-264489-h1n9ywbd	36	21	.	.	.
cord-264489-h1n9ywbd	37	1	This	this	DT
cord-264489-h1n9ywbd	37	2	apo	apo	NNP
cord-264489-h1n9ywbd	37	3	version	version	NN
cord-264489-h1n9ywbd	37	4	of	of	IN
cord-264489-h1n9ywbd	37	5	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	37	6	is	be	VBZ
cord-264489-h1n9ywbd	37	7	further	further	RB
cord-264489-h1n9ywbd	37	8	modified	modify	VBN
cord-264489-h1n9ywbd	37	9	by	by	IN
cord-264489-h1n9ywbd	37	10	Tsutsumi	Tsutsumi	NNP
cord-264489-h1n9ywbd	37	11	et	et	NNP
cord-264489-h1n9ywbd	37	12	al	al	NNP
cord-264489-h1n9ywbd	37	13	.	.	.
cord-264489-h1n9ywbd	38	1	(	(	-LRB-
cord-264489-h1n9ywbd	38	2	Tsutsumi	Tsutsumi	NNP
cord-264489-h1n9ywbd	38	3	et	et	NNP
cord-264489-h1n9ywbd	38	4	al	al	NNP
cord-264489-h1n9ywbd	38	5	.	.	NNP
cord-264489-h1n9ywbd	38	6	2014	2014	CD
cord-264489-h1n9ywbd	38	7	)	)	-RRB-
cord-264489-h1n9ywbd	38	8	.	.	.
cord-264489-h1n9ywbd	39	1	The	the	DT
cord-264489-h1n9ywbd	39	2	ligand	ligand	NN
cord-264489-h1n9ywbd	39	3	bound	bind	VBN
cord-264489-h1n9ywbd	39	4	holo	holo	JJ
cord-264489-h1n9ywbd	39	5	forms	form	NNS
cord-264489-h1n9ywbd	39	6	of	of	IN
cord-264489-h1n9ywbd	39	7	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	39	8	/	/	SYM
cord-264489-h1n9ywbd	39	9	IL-18R	IL-18R	NNP
cord-264489-h1n9ywbd	39	10	are	be	VBP
cord-264489-h1n9ywbd	39	11	also	also	RB
cord-264489-h1n9ywbd	39	12	elucidated	elucidate	VBN
cord-264489-h1n9ywbd	39	13	by	by	IN
cord-264489-h1n9ywbd	39	14	binding	bind	VBG
cord-264489-h1n9ywbd	39	15	protein	protein	NN
cord-264489-h1n9ywbd	39	16	(	(	-LRB-
cord-264489-h1n9ywbd	39	17	IL-18BP	IL-18BP	NNP
cord-264489-h1n9ywbd	39	18	)	)	-RRB-
cord-264489-h1n9ywbd	39	19	is	be	VBZ
cord-264489-h1n9ywbd	39	20	a	a	DT
cord-264489-h1n9ywbd	39	21	cell	cell	NN
cord-264489-h1n9ywbd	39	22	surface	surface	NN
cord-264489-h1n9ywbd	39	23	receptor	receptor	NN
cord-264489-h1n9ywbd	39	24	that	that	WDT
cord-264489-h1n9ywbd	39	25	binds	bind	VBZ
cord-264489-h1n9ywbd	39	26	to	to	IN
cord-264489-h1n9ywbd	39	27	and	and	CC
cord-264489-h1n9ywbd	39	28	eventually	eventually	RB
cord-264489-h1n9ywbd	39	29	leads	lead	VBZ
cord-264489-h1n9ywbd	39	30	to	to	IN
cord-264489-h1n9ywbd	39	31	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	39	32	neutralization	neutralization	NN
cord-264489-h1n9ywbd	39	33	(	(	-LRB-
cord-264489-h1n9ywbd	39	34	Dinarello	Dinarello	NNP
cord-264489-h1n9ywbd	39	35	et	et	FW
cord-264489-h1n9ywbd	39	36	al	al	NNP
cord-264489-h1n9ywbd	39	37	.	.	NNP
cord-264489-h1n9ywbd	39	38	2013	2013	CD
cord-264489-h1n9ywbd	39	39	)	)	-RRB-
cord-264489-h1n9ywbd	39	40	.	.	.
cord-264489-h1n9ywbd	40	1	A	a	DT
cord-264489-h1n9ywbd	40	2	recent	recent	JJ
cord-264489-h1n9ywbd	40	3	study	study	NN
cord-264489-h1n9ywbd	40	4	by	by	IN
cord-264489-h1n9ywbd	40	5	Krumm	Krumm	NNP
cord-264489-h1n9ywbd	40	6	et	et	NNP
cord-264489-h1n9ywbd	40	7	al	al	NNP
cord-264489-h1n9ywbd	40	8	.	.	NNP
cord-264489-h1n9ywbd	40	9	has	have	VBZ
cord-264489-h1n9ywbd	40	10	identified	identify	VBN
cord-264489-h1n9ywbd	40	11	the	the	DT
cord-264489-h1n9ywbd	40	12	conserved	conserve	VBN
cord-264489-h1n9ywbd	40	13	IL-18BP	IL-18BP	NNP
cord-264489-h1n9ywbd	40	14	interfacial	interfacial	JJ
cord-264489-h1n9ywbd	40	15	binding	binding	NN
cord-264489-h1n9ywbd	40	16	-	-	HYPH
cord-264489-h1n9ywbd	40	17	region	region	NN
cord-264489-h1n9ywbd	40	18	on	on	IN
cord-264489-h1n9ywbd	40	19	human	human	JJ
cord-264489-h1n9ywbd	40	20	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	40	21	(	(	-LRB-
cord-264489-h1n9ywbd	40	22	Krumm	Krumm	NNP
cord-264489-h1n9ywbd	40	23	et	et	FW
cord-264489-h1n9ywbd	40	24	al	al	NNP
cord-264489-h1n9ywbd	40	25	.	.	NNP
cord-264489-h1n9ywbd	40	26	2008	2008	CD
cord-264489-h1n9ywbd	40	27	)	)	-RRB-
cord-264489-h1n9ywbd	40	28	.	.	.
cord-264489-h1n9ywbd	41	1	In	in	IN
cord-264489-h1n9ywbd	41	2	recent	recent	JJ
cord-264489-h1n9ywbd	41	3	years	year	NNS
cord-264489-h1n9ywbd	41	4	,	,	,
cord-264489-h1n9ywbd	41	5	inhibitor	inhibitor	NN
cord-264489-h1n9ywbd	41	6	based	base	VBN
cord-264489-h1n9ywbd	41	7	therapies	therapy	NNS
cord-264489-h1n9ywbd	41	8	have	have	VBP
cord-264489-h1n9ywbd	41	9	shown	show	VBN
cord-264489-h1n9ywbd	41	10	great	great	JJ
cord-264489-h1n9ywbd	41	11	potentials	potential	NNS
cord-264489-h1n9ywbd	41	12	for	for	IN
cord-264489-h1n9ywbd	41	13	further	further	JJ
cord-264489-h1n9ywbd	41	14	developments	development	NNS
cord-264489-h1n9ywbd	41	15	in	in	IN
cord-264489-h1n9ywbd	41	16	the	the	DT
cord-264489-h1n9ywbd	41	17	pharma	pharma	NNS
cord-264489-h1n9ywbd	41	18	and	and	CC
cord-264489-h1n9ywbd	41	19	biotech	biotech	JJ
cord-264489-h1n9ywbd	41	20	sectors	sector	NNS
cord-264489-h1n9ywbd	41	21	(	(	-LRB-
cord-264489-h1n9ywbd	41	22	Vogt	Vogt	NNP
cord-264489-h1n9ywbd	41	23	and	and	CC
cord-264489-h1n9ywbd	41	24	Hofmann	Hofmann	NNP
cord-264489-h1n9ywbd	41	25	2012	2012	CD
cord-264489-h1n9ywbd	41	26	;	;	:
cord-264489-h1n9ywbd	41	27	Boulaki	Boulaki	NNP
cord-264489-h1n9ywbd	41	28	et	et	NNP
cord-264489-h1n9ywbd	41	29	al	al	NNP
cord-264489-h1n9ywbd	41	30	.	.	NNP
cord-264489-h1n9ywbd	41	31	2013	2013	CD
cord-264489-h1n9ywbd	41	32	;	;	:
cord-264489-h1n9ywbd	41	33	Zamiri	Zamiri	NNP
cord-264489-h1n9ywbd	41	34	et	et	NNP
cord-264489-h1n9ywbd	41	35	al	al	NNP
cord-264489-h1n9ywbd	41	36	.	.	.
cord-264489-h1n9ywbd	42	1	2014	2014	CD
cord-264489-h1n9ywbd	42	2	;	;	:
cord-264489-h1n9ywbd	42	3	Gonzalez	Gonzalez	NNP
cord-264489-h1n9ywbd	42	4	et	et	NNP
cord-264489-h1n9ywbd	42	5	al	al	NNP
cord-264489-h1n9ywbd	42	6	.	.	.
cord-264489-h1n9ywbd	42	7	2015	2015	CD
cord-264489-h1n9ywbd	42	8	;	;	:
cord-264489-h1n9ywbd	42	9	Lin	Lin	NNP
cord-264489-h1n9ywbd	42	10	et	et	NNP
cord-264489-h1n9ywbd	42	11	al	al	NNP
cord-264489-h1n9ywbd	42	12	.	.	.
cord-264489-h1n9ywbd	42	13	2017	2017	CD
cord-264489-h1n9ywbd	43	1	;	;	:
cord-264489-h1n9ywbd	43	2	Kwak	Kwak	NNP
cord-264489-h1n9ywbd	43	3	et	et	NNP
cord-264489-h1n9ywbd	43	4	al	al	NNP
cord-264489-h1n9ywbd	43	5	.	.	.
cord-264489-h1n9ywbd	43	6	2018	2018	CD
cord-264489-h1n9ywbd	43	7	)	)	-RRB-
cord-264489-h1n9ywbd	43	8	.	.	.
cord-264489-h1n9ywbd	44	1	The	the	DT
cord-264489-h1n9ywbd	44	2	treatments	treatment	NNS
cord-264489-h1n9ywbd	44	3	of	of	IN
cord-264489-h1n9ywbd	44	4	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	44	5	related	relate	VBN
cord-264489-h1n9ywbd	44	6	diseases	disease	NNS
cord-264489-h1n9ywbd	44	7	may	may	MD
cord-264489-h1n9ywbd	44	8	involve	involve	VB
cord-264489-h1n9ywbd	44	9	the	the	DT
cord-264489-h1n9ywbd	44	10	use	use	NN
cord-264489-h1n9ywbd	44	11	of	of	IN
cord-264489-h1n9ywbd	44	12	selective	selective	JJ
cord-264489-h1n9ywbd	44	13	or	or	CC
cord-264489-h1n9ywbd	44	14	potent	potent	JJ
cord-264489-h1n9ywbd	44	15	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	44	16	ligand/-receptor	ligand/-receptor	IN
cord-264489-h1n9ywbd	44	17	inhibitors	inhibitor	NNS
cord-264489-h1n9ywbd	44	18	that	that	WDT
cord-264489-h1n9ywbd	44	19	would	would	MD
cord-264489-h1n9ywbd	44	20	interfere	interfere	VB
cord-264489-h1n9ywbd	44	21	with	with	IN
cord-264489-h1n9ywbd	44	22	,	,	,
cord-264489-h1n9ywbd	44	23	or	or	CC
cord-264489-h1n9ywbd	44	24	effectively	effectively	RB
cord-264489-h1n9ywbd	44	25	block	block	VB
cord-264489-h1n9ywbd	44	26	the	the	DT
cord-264489-h1n9ywbd	44	27	targeted	target	VBN
cord-264489-h1n9ywbd	44	28	functions	function	NNS
cord-264489-h1n9ywbd	44	29	(	(	-LRB-
cord-264489-h1n9ywbd	44	30	Hamasaki	Hamasaki	NNP
cord-264489-h1n9ywbd	44	31	et	et	NNP
cord-264489-h1n9ywbd	44	32	al	al	NNP
cord-264489-h1n9ywbd	44	33	.	.	NNP
cord-264489-h1n9ywbd	44	34	2005	2005	CD
cord-264489-h1n9ywbd	44	35	;	;	:
cord-264489-h1n9ywbd	44	36	 	 	_SP
cord-264489-h1n9ywbd	44	37	J	J	NNP
cord-264489-h1n9ywbd	44	38	o	o	NN
cord-264489-h1n9ywbd	44	39	u	u	NN
cord-264489-h1n9ywbd	44	40	r	r	NN
cord-264489-h1n9ywbd	44	41	n	n	NN
cord-264489-h1n9ywbd	44	42	a	a	DT
cord-264489-h1n9ywbd	44	43	l	l	NN
cord-264489-h1n9ywbd	44	44	P	p	NN
cord-264489-h1n9ywbd	44	45	r	r	NN
cord-264489-h1n9ywbd	44	46	e	e	NN
cord-264489-h1n9ywbd	44	47	-p	-p	NN
cord-264489-h1n9ywbd	44	48	r	r	NN
cord-264489-h1n9ywbd	44	49	o	o	NN
cord-264489-h1n9ywbd	44	50	o	o	NN
cord-264489-h1n9ywbd	44	51	f	f	NN
cord-264489-h1n9ywbd	44	52	Tsutsumi	Tsutsumi	NNP
cord-264489-h1n9ywbd	44	53	et	et	NNP
cord-264489-h1n9ywbd	44	54	al	al	NNP
cord-264489-h1n9ywbd	44	55	.	.	.
cord-264489-h1n9ywbd	44	56	2019	2019	CD
cord-264489-h1n9ywbd	44	57	)	)	-RRB-
cord-264489-h1n9ywbd	44	58	.	.	.
cord-264489-h1n9ywbd	45	1	In	in	IN
cord-264489-h1n9ywbd	45	2	our	-PRON-	PRP$
cord-264489-h1n9ywbd	45	3	earlier	early	JJR
cord-264489-h1n9ywbd	45	4	papers	paper	NNS
cord-264489-h1n9ywbd	45	5	we	-PRON-	PRP
cord-264489-h1n9ywbd	45	6	have	have	VBP
cord-264489-h1n9ywbd	45	7	described	describe	VBN
cord-264489-h1n9ywbd	45	8	the	the	DT
cord-264489-h1n9ywbd	45	9	structures	structure	NNS
cord-264489-h1n9ywbd	45	10	and	and	CC
cord-264489-h1n9ywbd	45	11	structure	structure	NN
cord-264489-h1n9ywbd	45	12	-	-	HYPH
cord-264489-h1n9ywbd	45	13	related	relate	VBN
cord-264489-h1n9ywbd	45	14	functional	functional	JJ
cord-264489-h1n9ywbd	45	15	changes	change	NNS
cord-264489-h1n9ywbd	45	16	of	of	IN
cord-264489-h1n9ywbd	45	17	several	several	JJ
cord-264489-h1n9ywbd	45	18	physiologically	physiologically	RB
cord-264489-h1n9ywbd	45	19	relevant	relevant	JJ
cord-264489-h1n9ywbd	45	20	proteins	protein	NNS
cord-264489-h1n9ywbd	45	21	(	(	-LRB-
cord-264489-h1n9ywbd	45	22	Roy	Roy	NNP
cord-264489-h1n9ywbd	45	23	and	and	CC
cord-264489-h1n9ywbd	45	24	Luck	Luck	NNP
cord-264489-h1n9ywbd	45	25	2007	2007	CD
cord-264489-h1n9ywbd	45	26	;	;	:
cord-264489-h1n9ywbd	45	27	Roy	Roy	NNP
cord-264489-h1n9ywbd	45	28	2016a	2016a	CD
cord-264489-h1n9ywbd	45	29	Roy	Roy	NNP
cord-264489-h1n9ywbd	45	30	,	,	,
cord-264489-h1n9ywbd	45	31	2016b	2016b	CD
cord-264489-h1n9ywbd	45	32	Roy	Roy	NNP
cord-264489-h1n9ywbd	45	33	,	,	,
cord-264489-h1n9ywbd	45	34	2017	2017	CD
cord-264489-h1n9ywbd	45	35	Roy	Roy	NNP
cord-264489-h1n9ywbd	45	36	,	,	,
cord-264489-h1n9ywbd	45	37	2019a	2019a	CD
cord-264489-h1n9ywbd	45	38	Roy	Roy	NNP
cord-264489-h1n9ywbd	45	39	,	,	,
cord-264489-h1n9ywbd	45	40	2019b	2019b	CD
cord-264489-h1n9ywbd	45	41	Roy	Roy	NNP
cord-264489-h1n9ywbd	45	42	,	,	,
cord-264489-h1n9ywbd	45	43	2020	2020	CD
cord-264489-h1n9ywbd	45	44	.	.	.
cord-264489-h1n9ywbd	46	1	The	the	DT
cord-264489-h1n9ywbd	46	2	present	present	JJ
cord-264489-h1n9ywbd	46	3	simulation	simulation	NN
cord-264489-h1n9ywbd	46	4	study	study	NN
cord-264489-h1n9ywbd	46	5	examines	examine	VBZ
cord-264489-h1n9ywbd	46	6	the	the	DT
cord-264489-h1n9ywbd	46	7	structural	structural	JJ
cord-264489-h1n9ywbd	46	8	stabilities	stability	NNS
cord-264489-h1n9ywbd	46	9	of	of	IN
cord-264489-h1n9ywbd	46	10	the	the	DT
cord-264489-h1n9ywbd	46	11	ligand	ligand	NN
cord-264489-h1n9ywbd	46	12	-	-	HYPH
cord-264489-h1n9ywbd	46	13	protein	protein	NN
cord-264489-h1n9ywbd	46	14	,	,	,
cord-264489-h1n9ywbd	46	15	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	46	16	and	and	CC
cord-264489-h1n9ywbd	46	17	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	46	18	receptor	receptor	NN
cord-264489-h1n9ywbd	46	19	(	(	-LRB-
cord-264489-h1n9ywbd	46	20	IL-18R	IL-18R	NNP
cord-264489-h1n9ywbd	46	21	)	)	-RRB-
cord-264489-h1n9ywbd	46	22	bound	bind	VBN
cord-264489-h1n9ywbd	46	23	ligand	ligand	NN
cord-264489-h1n9ywbd	46	24	structures	structure	NNS
cord-264489-h1n9ywbd	46	25	as	as	IN
cord-264489-h1n9ywbd	46	26	functions	function	NNS
cord-264489-h1n9ywbd	46	27	of	of	IN
cord-264489-h1n9ywbd	46	28	time	time	NN
cord-264489-h1n9ywbd	46	29	.	.	.
cord-264489-h1n9ywbd	47	1	We	-PRON-	PRP
cord-264489-h1n9ywbd	47	2	analyze	analyze	VBP
cord-264489-h1n9ywbd	47	3	here	here	RB
cord-264489-h1n9ywbd	47	4	the	the	DT
cord-264489-h1n9ywbd	47	5	conformational	conformational	JJ
cord-264489-h1n9ywbd	47	6	changes	change	NNS
cord-264489-h1n9ywbd	47	7	within	within	IN
cord-264489-h1n9ywbd	47	8	the	the	DT
cord-264489-h1n9ywbd	47	9	ligand	ligand	NN
cord-264489-h1n9ywbd	47	10	-	-	HYPH
cord-264489-h1n9ywbd	47	11	protein	protein	NN
cord-264489-h1n9ywbd	47	12	,	,	,
cord-264489-h1n9ywbd	47	13	due	due	IN
cord-264489-h1n9ywbd	47	14	to	to	IN
cord-264489-h1n9ywbd	47	15	receptor	receptor	NN
cord-264489-h1n9ywbd	47	16	binding	binding	NN
cord-264489-h1n9ywbd	47	17	and	and	CC
cord-264489-h1n9ywbd	47	18	,	,	,
cord-264489-h1n9ywbd	47	19	we	-PRON-	PRP
cord-264489-h1n9ywbd	47	20	also	also	RB
cord-264489-h1n9ywbd	47	21	identify	identify	VBP
cord-264489-h1n9ywbd	47	22	the	the	DT
cord-264489-h1n9ywbd	47	23	possible	possible	JJ
cord-264489-h1n9ywbd	47	24	structurally	structurally	RB
cord-264489-h1n9ywbd	47	25	ordered	order	VBN
cord-264489-h1n9ywbd	47	26	and	and	CC
cord-264489-h1n9ywbd	47	27	disordered	disordered	JJ
cord-264489-h1n9ywbd	47	28	region	region	NN
cord-264489-h1n9ywbd	47	29	within	within	IN
cord-264489-h1n9ywbd	47	30	the	the	DT
cord-264489-h1n9ywbd	47	31	apo	apo	NNP
cord-264489-h1n9ywbd	47	32	and	and	CC
cord-264489-h1n9ywbd	47	33	holo	holo	NNP
cord-264489-h1n9ywbd	47	34	(	(	-LRB-
cord-264489-h1n9ywbd	47	35	ligand	ligand	NN
cord-264489-h1n9ywbd	47	36	-	-	HYPH
cord-264489-h1n9ywbd	47	37	bound	bind	VBN
cord-264489-h1n9ywbd	47	38	)	)	-RRB-
cord-264489-h1n9ywbd	47	39	protein	protein	NN
cord-264489-h1n9ywbd	47	40	complexes	complex	NNS
cord-264489-h1n9ywbd	47	41	.	.	.
cord-264489-h1n9ywbd	48	1	All	all	DT
cord-264489-h1n9ywbd	48	2	protein	protein	NN
cord-264489-h1n9ywbd	48	3	structures	structure	NNS
cord-264489-h1n9ywbd	48	4	were	be	VBD
cord-264489-h1n9ywbd	48	5	collected	collect	VBN
cord-264489-h1n9ywbd	48	6	from	from	IN
cord-264489-h1n9ywbd	48	7	the	the	DT
cord-264489-h1n9ywbd	48	8	Protein	Protein	NNP
cord-264489-h1n9ywbd	48	9	Databank	Databank	NNP
cord-264489-h1n9ywbd	48	10	(	(	-LRB-
cord-264489-h1n9ywbd	48	11	PDB	PDB	NNP
cord-264489-h1n9ywbd	48	12	)	)	-RRB-
cord-264489-h1n9ywbd	48	13	website	website	NN
cord-264489-h1n9ywbd	48	14	(	(	-LRB-
cord-264489-h1n9ywbd	48	15	Berman	Berman	NNP
cord-264489-h1n9ywbd	48	16	et	et	NNP
cord-264489-h1n9ywbd	48	17	al	al	NNP
cord-264489-h1n9ywbd	48	18	.	.	.
cord-264489-h1n9ywbd	48	19	2000	2000	CD
cord-264489-h1n9ywbd	48	20	)	)	-RRB-
cord-264489-h1n9ywbd	48	21	in	in	IN
cord-264489-h1n9ywbd	48	22	the	the	DT
cord-264489-h1n9ywbd	48	23	form	form	NN
cord-264489-h1n9ywbd	48	24	of	of	IN
cord-264489-h1n9ywbd	48	25	standard	standard	JJ
cord-264489-h1n9ywbd	48	26	PDB	PDB	NNP
cord-264489-h1n9ywbd	48	27	files	file	NNS
cord-264489-h1n9ywbd	48	28	.	.	.
cord-264489-h1n9ywbd	49	1	For	for	IN
cord-264489-h1n9ywbd	49	2	structural	structural	JJ
cord-264489-h1n9ywbd	49	3	studies	study	NNS
cord-264489-h1n9ywbd	49	4	,	,	,
cord-264489-h1n9ywbd	49	5	we	-PRON-	PRP
cord-264489-h1n9ywbd	49	6	have	have	VBP
cord-264489-h1n9ywbd	49	7	used	use	VBN
cord-264489-h1n9ywbd	49	8	Nuclear	Nuclear	NNP
cord-264489-h1n9ywbd	49	9	Magnetic	Magnetic	NNP
cord-264489-h1n9ywbd	49	10	Resonance	Resonance	NNP
cord-264489-h1n9ywbd	49	11	(	(	-LRB-
cord-264489-h1n9ywbd	49	12	NMR	NMR	NNP
cord-264489-h1n9ywbd	49	13	)	)	-RRB-
cord-264489-h1n9ywbd	49	14	and	and	CC
cord-264489-h1n9ywbd	49	15	X	x	NN
cord-264489-h1n9ywbd	49	16	-	-	NN
cord-264489-h1n9ywbd	49	17	ray	ray	NN
cord-264489-h1n9ywbd	49	18	crystallographic	crystallographic	JJ
cord-264489-h1n9ywbd	49	19	structures	structure	NNS
cord-264489-h1n9ywbd	49	20	of	of	IN
cord-264489-h1n9ywbd	49	21	the	the	DT
cord-264489-h1n9ywbd	49	22	human	human	JJ
cord-264489-h1n9ywbd	49	23	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	49	24	ligand	ligand	NN
cord-264489-h1n9ywbd	49	25	-	-	HYPH
cord-264489-h1n9ywbd	49	26	protein	protein	NN
cord-264489-h1n9ywbd	49	27	1J0S.PDB	1j0s.pdb	CD
cord-264489-h1n9ywbd	50	1	(	(	-LRB-
cord-264489-h1n9ywbd	50	2	Kato	Kato	NNP
cord-264489-h1n9ywbd	50	3	et	et	NNP
cord-264489-h1n9ywbd	50	4	al	al	NNP
cord-264489-h1n9ywbd	50	5	.	.	NNP
cord-264489-h1n9ywbd	50	6	2003	2003	CD
cord-264489-h1n9ywbd	50	7	)	)	-RRB-
cord-264489-h1n9ywbd	50	8	and	and	CC
cord-264489-h1n9ywbd	50	9	3WO2.PDB	3wo2.pdb	CD
cord-264489-h1n9ywbd	50	10	,	,	,
cord-264489-h1n9ywbd	51	1	(	(	-LRB-
cord-264489-h1n9ywbd	51	2	Tsutsumi	Tsutsumi	NNP
cord-264489-h1n9ywbd	51	3	et	et	NNP
cord-264489-h1n9ywbd	51	4	al	al	NNP
cord-264489-h1n9ywbd	51	5	.	.	NNP
cord-264489-h1n9ywbd	51	6	2014	2014	CD
cord-264489-h1n9ywbd	51	7	)	)	-RRB-
cord-264489-h1n9ywbd	51	8	.	.	.
cord-264489-h1n9ywbd	52	1	Additionally	additionally	RB
cord-264489-h1n9ywbd	52	2	3WO3.PDB	3WO3.PDB	NNP
cord-264489-h1n9ywbd	52	3	and	and	CC
cord-264489-h1n9ywbd	52	4	3WO4.PDB	3WO4.PDB	NNP
cord-264489-h1n9ywbd	52	5	,	,	,
cord-264489-h1n9ywbd	52	6	the	the	DT
cord-264489-h1n9ywbd	52	7	X	x	NN
cord-264489-h1n9ywbd	52	8	-	-	NN
cord-264489-h1n9ywbd	52	9	ray	ray	NN
cord-264489-h1n9ywbd	52	10	crystallographic	crystallographic	JJ
cord-264489-h1n9ywbd	52	11	structures	structure	NNS
cord-264489-h1n9ywbd	52	12	of	of	IN
cord-264489-h1n9ywbd	52	13	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	52	14	receptor	receptor	NN
cord-264489-h1n9ywbd	52	15	bound	bind	VBN
cord-264489-h1n9ywbd	52	16	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	52	17	and	and	CC
cord-264489-h1n9ywbd	52	18	the	the	DT
cord-264489-h1n9ywbd	52	19	ternary	ternary	JJ
cord-264489-h1n9ywbd	52	20	signaling	signal	VBG
cord-264489-h1n9ywbd	52	21	complex	complex	NN
cord-264489-h1n9ywbd	52	22	of	of	IN
cord-264489-h1n9ywbd	52	23	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	52	24	have	have	VBP
cord-264489-h1n9ywbd	52	25	been	be	VBN
cord-264489-h1n9ywbd	52	26	utilized	utilize	VBN
cord-264489-h1n9ywbd	53	1	(	(	-LRB-
cord-264489-h1n9ywbd	53	2	Tsutsumi	Tsutsumi	NNP
cord-264489-h1n9ywbd	53	3	et	et	NNP
cord-264489-h1n9ywbd	53	4	al	al	NNP
cord-264489-h1n9ywbd	53	5	.	.	NNP
cord-264489-h1n9ywbd	53	6	2014	2014	CD
cord-264489-h1n9ywbd	53	7	)	)	-RRB-
cord-264489-h1n9ywbd	53	8	.	.	.
cord-264489-h1n9ywbd	54	1	The	the	DT
cord-264489-h1n9ywbd	54	2	3F62.PDB	3f62.pdb	CD
cord-264489-h1n9ywbd	54	3	,	,	,
cord-264489-h1n9ywbd	54	4	an	an	DT
cord-264489-h1n9ywbd	54	5	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	54	6	complex	complex	JJ
cord-264489-h1n9ywbd	54	7	with	with	IN
cord-264489-h1n9ywbd	54	8	IL-18BP	IL-18BP	NNP
cord-264489-h1n9ywbd	54	9	of	of	IN
cord-264489-h1n9ywbd	54	10	Ectromelia	Ectromelia	NNP
cord-264489-h1n9ywbd	54	11	virus	virus	NN
cord-264489-h1n9ywbd	54	12	has	have	VBZ
cord-264489-h1n9ywbd	54	13	also	also	RB
cord-264489-h1n9ywbd	54	14	been	be	VBN
cord-264489-h1n9ywbd	54	15	briefly	briefly	RB
cord-264489-h1n9ywbd	54	16	mentioned	mention	VBN
cord-264489-h1n9ywbd	54	17	(	(	-LRB-
cord-264489-h1n9ywbd	54	18	Krumm	Krumm	NNP
cord-264489-h1n9ywbd	54	19	et	et	FW
cord-264489-h1n9ywbd	54	20	al	al	NNP
cord-264489-h1n9ywbd	54	21	.	.	NNP
cord-264489-h1n9ywbd	54	22	2008	2008	CD
cord-264489-h1n9ywbd	54	23	)	)	-RRB-
cord-264489-h1n9ywbd	54	24	.	.	.
cord-264489-h1n9ywbd	55	1	The	the	DT
cord-264489-h1n9ywbd	55	2	resolution	resolution	NN
cord-264489-h1n9ywbd	55	3	values	value	NNS
cord-264489-h1n9ywbd	55	4	for	for	IN
cord-264489-h1n9ywbd	55	5	the	the	DT
cord-264489-h1n9ywbd	55	6	X	x	NN
cord-264489-h1n9ywbd	55	7	-	-	NN
cord-264489-h1n9ywbd	55	8	ray	ray	NN
cord-264489-h1n9ywbd	55	9	structures	structure	NNS
cord-264489-h1n9ywbd	55	10	3WO2	3wo2	RB
cord-264489-h1n9ywbd	55	11	,	,	,
cord-264489-h1n9ywbd	55	12	3WO3	3wo3	CD
cord-264489-h1n9ywbd	55	13	,	,	,
cord-264489-h1n9ywbd	55	14	3WO4	3wo4	CD
cord-264489-h1n9ywbd	55	15	and	and	CC
cord-264489-h1n9ywbd	55	16	3F62	3f62	CD
cord-264489-h1n9ywbd	55	17	are	be	VBP
cord-264489-h1n9ywbd	55	18	2.33	2.33	CD
cord-264489-h1n9ywbd	55	19	Å	å	NN
cord-264489-h1n9ywbd	55	20	,	,	,
cord-264489-h1n9ywbd	55	21	3.10	3.10	CD
cord-264489-h1n9ywbd	55	22	Å	å	NN
cord-264489-h1n9ywbd	55	23	,	,	,
cord-264489-h1n9ywbd	55	24	3.10	3.10	CD
cord-264489-h1n9ywbd	55	25	Å	å	NN
cord-264489-h1n9ywbd	55	26	and	and	CC
cord-264489-h1n9ywbd	55	27	2.00	2.00	CD
cord-264489-h1n9ywbd	55	28	Å	å	NN
cord-264489-h1n9ywbd	55	29	respectively	respectively	RB
cord-264489-h1n9ywbd	55	30	.	.	.
cord-264489-h1n9ywbd	56	1	Nanoscale	Nanoscale	NNP
cord-264489-h1n9ywbd	56	2	Molecular	Molecular	NNP
cord-264489-h1n9ywbd	56	3	Dynamics	Dynamics	NNP
cord-264489-h1n9ywbd	56	4	(	(	-LRB-
cord-264489-h1n9ywbd	56	5	NAMD	NAMD	NNP
cord-264489-h1n9ywbd	56	6	)	)	-RRB-
cord-264489-h1n9ywbd	56	7	and	and	CC
cord-264489-h1n9ywbd	56	8	Visual	Visual	NNP
cord-264489-h1n9ywbd	56	9	Molecular	Molecular	NNP
cord-264489-h1n9ywbd	56	10	Dynamics	Dynamics	NNPS
cord-264489-h1n9ywbd	56	11	(	(	-LRB-
cord-264489-h1n9ywbd	56	12	VMD	VMD	NNP
cord-264489-h1n9ywbd	56	13	)	)	-RRB-
cord-264489-h1n9ywbd	56	14	programs	program	NNS
cord-264489-h1n9ywbd	56	15	were	be	VBD
cord-264489-h1n9ywbd	56	16	used	use	VBN
cord-264489-h1n9ywbd	56	17	for	for	IN
cord-264489-h1n9ywbd	56	18	time	time	NN
cord-264489-h1n9ywbd	56	19	-	-	HYPH
cord-264489-h1n9ywbd	56	20	based	base	VBN
cord-264489-h1n9ywbd	56	21	simulations	simulation	NNS
cord-264489-h1n9ywbd	56	22	(	(	-LRB-
cord-264489-h1n9ywbd	56	23	Humphrey	Humphrey	NNP
cord-264489-h1n9ywbd	56	24	et	et	NNP
cord-264489-h1n9ywbd	56	25	al	al	NNP
cord-264489-h1n9ywbd	56	26	.	.	.
cord-264489-h1n9ywbd	56	27	1996	1996	CD
cord-264489-h1n9ywbd	56	28	;	;	:
cord-264489-h1n9ywbd	56	29	Phillips	Phillips	NNP
cord-264489-h1n9ywbd	56	30	et	et	NNP
cord-264489-h1n9ywbd	56	31	al	al	NNP
cord-264489-h1n9ywbd	56	32	.	.	NNP
cord-264489-h1n9ywbd	56	33	2005	2005	CD
cord-264489-h1n9ywbd	56	34	)	)	-RRB-
cord-264489-h1n9ywbd	56	35	,	,	,
cord-264489-h1n9ywbd	56	36	and	and	CC
cord-264489-h1n9ywbd	56	37	the	the	DT
cord-264489-h1n9ywbd	56	38	J	J	NNP
cord-264489-h1n9ywbd	56	39	o	o	NN
cord-264489-h1n9ywbd	56	40	u	u	NN
cord-264489-h1n9ywbd	56	41	r	r	NN
cord-264489-h1n9ywbd	56	42	n	n	NN
cord-264489-h1n9ywbd	56	43	a	a	DT
cord-264489-h1n9ywbd	56	44	l	l	NN
cord-264489-h1n9ywbd	56	45	P	p	NN
cord-264489-h1n9ywbd	56	46	r	r	NN
cord-264489-h1n9ywbd	56	47	e	e	NN
cord-264489-h1n9ywbd	56	48	-p	-p	NN
cord-264489-h1n9ywbd	56	49	r	r	NN
cord-264489-h1n9ywbd	56	50	o	o	NN
cord-264489-h1n9ywbd	56	51	o	o	NN
cord-264489-h1n9ywbd	56	52	f	f	NN
cord-264489-h1n9ywbd	56	53	aligned	align	VBN
cord-264489-h1n9ywbd	56	54	sequences	sequence	NNS
cord-264489-h1n9ywbd	56	55	were	be	VBD
cord-264489-h1n9ywbd	56	56	studied	study	VBN
cord-264489-h1n9ywbd	56	57	with	with	IN
cord-264489-h1n9ywbd	56	58	Molecular	Molecular	NNP
cord-264489-h1n9ywbd	56	59	Evolutionary	Evolutionary	NNP
cord-264489-h1n9ywbd	56	60	Genetics	Genetics	NNP
cord-264489-h1n9ywbd	56	61	Analysis	Analysis	NNP
cord-264489-h1n9ywbd	56	62	(	(	-LRB-
cord-264489-h1n9ywbd	56	63	MEGA	MEGA	NNP
cord-264489-h1n9ywbd	56	64	7	7	CD
cord-264489-h1n9ywbd	56	65	)	)	-RRB-
cord-264489-h1n9ywbd	56	66	(	(	-LRB-
cord-264489-h1n9ywbd	56	67	Kumar	Kumar	NNP
cord-264489-h1n9ywbd	56	68	et	et	NNP
cord-264489-h1n9ywbd	56	69	al	al	NNP
cord-264489-h1n9ywbd	56	70	.	.	.
cord-264489-h1n9ywbd	56	71	2016	2016	CD
cord-264489-h1n9ywbd	56	72	)	)	-RRB-
cord-264489-h1n9ywbd	56	73	.	.	.
cord-264489-h1n9ywbd	57	1	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	57	2	interactome	interactome	NNP
cord-264489-h1n9ywbd	57	3	analyses	analysis	NNS
cord-264489-h1n9ywbd	57	4	were	be	VBD
cord-264489-h1n9ywbd	57	5	performed	perform	VBN
cord-264489-h1n9ywbd	57	6	using	use	VBG
cord-264489-h1n9ywbd	57	7	the	the	DT
cord-264489-h1n9ywbd	57	8	Cytoscope	Cytoscope	NNP
cord-264489-h1n9ywbd	57	9	package	package	NN
cord-264489-h1n9ywbd	57	10	(	(	-LRB-
cord-264489-h1n9ywbd	57	11	Shannon	Shannon	NNP
cord-264489-h1n9ywbd	57	12	et	et	NNP
cord-264489-h1n9ywbd	57	13	al	al	NNP
cord-264489-h1n9ywbd	57	14	.	.	NNP
cord-264489-h1n9ywbd	57	15	2003	2003	CD
cord-264489-h1n9ywbd	57	16	)	)	-RRB-
cord-264489-h1n9ywbd	57	17	,	,	,
cord-264489-h1n9ywbd	57	18	and	and	CC
cord-264489-h1n9ywbd	57	19	3D	3D	NNP
cord-264489-h1n9ywbd	57	20	protein	protein	NN
cord-264489-h1n9ywbd	57	21	graphics	graphic	NNS
cord-264489-h1n9ywbd	57	22	were	be	VBD
cord-264489-h1n9ywbd	57	23	developed	develop	VBN
cord-264489-h1n9ywbd	57	24	with	with	IN
cord-264489-h1n9ywbd	57	25	Biovia	Biovia	NNP
cord-264489-h1n9ywbd	57	26	Discovery	Discovery	NNP
cord-264489-h1n9ywbd	57	27	Studio	Studio	NNP
cord-264489-h1n9ywbd	57	28	Visualizer	Visualizer	NNP
cord-264489-h1n9ywbd	57	29	,	,	,
cord-264489-h1n9ywbd	57	30	v16.1.0.15350	v16.1.0.15350	NNP
cord-264489-h1n9ywbd	57	31	(	(	-LRB-
cord-264489-h1n9ywbd	57	32	Dassault	Dassault	NNP
cord-264489-h1n9ywbd	57	33	Systèmes	Systèmes	NNP
cord-264489-h1n9ywbd	57	34	BIOVIA	BIOVIA	NNP
cord-264489-h1n9ywbd	57	35	Discovery	Discovery	NNP
cord-264489-h1n9ywbd	57	36	Studio	Studio	NNP
cord-264489-h1n9ywbd	57	37	Modeling	Modeling	NNP
cord-264489-h1n9ywbd	57	38	Environment	Environment	NNP
cord-264489-h1n9ywbd	57	39	2015	2015	CD
cord-264489-h1n9ywbd	57	40	)	)	-RRB-
cord-264489-h1n9ywbd	57	41	.	.	.
cord-264489-h1n9ywbd	58	1	The	the	DT
cord-264489-h1n9ywbd	58	2	plots	plot	NNS
cord-264489-h1n9ywbd	58	3	were	be	VBD
cord-264489-h1n9ywbd	58	4	constructed	construct	VBN
cord-264489-h1n9ywbd	58	5	with	with	IN
cord-264489-h1n9ywbd	58	6	Origin	Origin	NNP
cord-264489-h1n9ywbd	58	7	(	(	-LRB-
cord-264489-h1n9ywbd	58	8	OriginLab	OriginLab	NNP
cord-264489-h1n9ywbd	58	9	Corporation	Corporation	NNP
cord-264489-h1n9ywbd	58	10	2016	2016	CD
cord-264489-h1n9ywbd	58	11	)	)	-RRB-
cord-264489-h1n9ywbd	58	12	.	.	.
cord-264489-h1n9ywbd	59	1	The	the	DT
cord-264489-h1n9ywbd	59	2	experimental	experimental	JJ
cord-264489-h1n9ywbd	59	3	simulation	simulation	NN
cord-264489-h1n9ywbd	59	4	setup	setup	NN
cord-264489-h1n9ywbd	59	5	for	for	IN
cord-264489-h1n9ywbd	59	6	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	59	7	and	and	CC
cord-264489-h1n9ywbd	59	8	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	59	9	/	/	SYM
cord-264489-h1n9ywbd	59	10	IL-18R	IL-18R	NNP
cord-264489-h1n9ywbd	59	11	were	be	VBD
cord-264489-h1n9ywbd	59	12	similar	similar	JJ
cord-264489-h1n9ywbd	59	13	to	to	IN
cord-264489-h1n9ywbd	59	14	those	those	DT
cord-264489-h1n9ywbd	59	15	reported	report	VBN
cord-264489-h1n9ywbd	59	16	previously	previously	RB
cord-264489-h1n9ywbd	59	17	(	(	-LRB-
cord-264489-h1n9ywbd	59	18	Roy	Roy	NNP
cord-264489-h1n9ywbd	59	19	2016a	2016a	CD
cord-264489-h1n9ywbd	59	20	(	(	-LRB-
cord-264489-h1n9ywbd	59	21	Roy	Roy	NNP
cord-264489-h1n9ywbd	59	22	,	,	,
cord-264489-h1n9ywbd	59	23	2016b	2016b	CD
cord-264489-h1n9ywbd	59	24	(	(	-LRB-
cord-264489-h1n9ywbd	59	25	Roy	Roy	NNP
cord-264489-h1n9ywbd	59	26	,	,	,
cord-264489-h1n9ywbd	59	27	2017	2017	CD
cord-264489-h1n9ywbd	59	28	(	(	-LRB-
cord-264489-h1n9ywbd	59	29	Roy	Roy	NNP
cord-264489-h1n9ywbd	59	30	,	,	,
cord-264489-h1n9ywbd	59	31	2019a	2019a	CD
cord-264489-h1n9ywbd	59	32	(	(	-LRB-
cord-264489-h1n9ywbd	59	33	Roy	Roy	NNP
cord-264489-h1n9ywbd	59	34	,	,	,
cord-264489-h1n9ywbd	59	35	2019b	2019b	CD
cord-264489-h1n9ywbd	59	36	(	(	-LRB-
cord-264489-h1n9ywbd	59	37	Roy	Roy	NNP
cord-264489-h1n9ywbd	59	38	,	,	,
cord-264489-h1n9ywbd	59	39	2020	2020	CD
cord-264489-h1n9ywbd	59	40	.	.	.
cord-264489-h1n9ywbd	60	1	Based	base	VBN
cord-264489-h1n9ywbd	60	2	on	on	IN
cord-264489-h1n9ywbd	60	3	the	the	DT
cord-264489-h1n9ywbd	60	4	native	native	JJ
cord-264489-h1n9ywbd	60	5	/	/	SYM
cord-264489-h1n9ywbd	60	6	original	original	JJ
cord-264489-h1n9ywbd	60	7	protein	protein	NN
cord-264489-h1n9ywbd	60	8	,	,	,
cord-264489-h1n9ywbd	60	9	the	the	DT
cord-264489-h1n9ywbd	60	10	protein	protein	NN
cord-264489-h1n9ywbd	60	11	structure	structure	NN
cord-264489-h1n9ywbd	60	12	file	file	NN
cord-264489-h1n9ywbd	60	13	(	(	-LRB-
cord-264489-h1n9ywbd	60	14	PSF	psf	NN
cord-264489-h1n9ywbd	60	15	)	)	-RRB-
cord-264489-h1n9ywbd	60	16	along	along	IN
cord-264489-h1n9ywbd	60	17	with	with	IN
cord-264489-h1n9ywbd	60	18	a	a	DT
cord-264489-h1n9ywbd	60	19	corresponding	corresponding	JJ
cord-264489-h1n9ywbd	60	20	PDB	PDB	NNP
cord-264489-h1n9ywbd	60	21	structure	structure	NN
cord-264489-h1n9ywbd	60	22	was	be	VBD
cord-264489-h1n9ywbd	60	23	generated	generate	VBN
cord-264489-h1n9ywbd	60	24	.	.	.
cord-264489-h1n9ywbd	61	1	The	the	DT
cord-264489-h1n9ywbd	61	2	NAMD	NAMD	NNP
cord-264489-h1n9ywbd	61	3	software	software	NN
cord-264489-h1n9ywbd	61	4	required	require	VBD
cord-264489-h1n9ywbd	61	5	both	both	CC
cord-264489-h1n9ywbd	61	6	the	the	DT
cord-264489-h1n9ywbd	61	7	PSF	psf	NN
cord-264489-h1n9ywbd	61	8	and	and	CC
cord-264489-h1n9ywbd	61	9	the	the	DT
cord-264489-h1n9ywbd	61	10	modified	modify	VBN
cord-264489-h1n9ywbd	61	11	PDB	PDB	NNP
cord-264489-h1n9ywbd	61	12	files	file	NNS
cord-264489-h1n9ywbd	61	13	as	as	IN
cord-264489-h1n9ywbd	61	14	simulation	simulation	NN
cord-264489-h1n9ywbd	61	15	inputs	input	NNS
cord-264489-h1n9ywbd	61	16	,	,	,
cord-264489-h1n9ywbd	61	17	and	and	CC
cord-264489-h1n9ywbd	61	18	these	these	DT
cord-264489-h1n9ywbd	61	19	files	file	NNS
cord-264489-h1n9ywbd	61	20	were	be	VBD
cord-264489-h1n9ywbd	61	21	created	create	VBN
cord-264489-h1n9ywbd	61	22	using	use	VBG
cord-264489-h1n9ywbd	61	23	the	the	DT
cord-264489-h1n9ywbd	61	24	Automatic	Automatic	NNP
cord-264489-h1n9ywbd	61	25	PSF	PSF	NNP
cord-264489-h1n9ywbd	61	26	Builder	Builder	NNP
cord-264489-h1n9ywbd	61	27	(	(	-LRB-
cord-264489-h1n9ywbd	61	28	autoPSF	autoPSF	NNP
cord-264489-h1n9ywbd	61	29	)	)	-RRB-
cord-264489-h1n9ywbd	61	30	graphical	graphical	JJ
cord-264489-h1n9ywbd	61	31	user	user	NN
cord-264489-h1n9ywbd	61	32	interface	interface	NN
cord-264489-h1n9ywbd	61	33	(	(	-LRB-
cord-264489-h1n9ywbd	61	34	gui	gui	NNP
cord-264489-h1n9ywbd	61	35	)	)	-RRB-
cord-264489-h1n9ywbd	61	36	of	of	IN
cord-264489-h1n9ywbd	61	37	VMD	VMD	NNP
cord-264489-h1n9ywbd	61	38	.	.	.
cord-264489-h1n9ywbd	62	1	The	the	DT
cord-264489-h1n9ywbd	62	2	topology	topology	NN
cord-264489-h1n9ywbd	62	3	file	file	NN
cord-264489-h1n9ywbd	62	4	,	,	,
cord-264489-h1n9ywbd	62	5	PSF	PSF	NNP
cord-264489-h1n9ywbd	62	6	had	have	VBD
cord-264489-h1n9ywbd	62	7	all	all	PDT
cord-264489-h1n9ywbd	62	8	the	the	DT
cord-264489-h1n9ywbd	62	9	structural	structural	JJ
cord-264489-h1n9ywbd	62	10	information	information	NN
cord-264489-h1n9ywbd	62	11	while	while	IN
cord-264489-h1n9ywbd	62	12	the	the	DT
cord-264489-h1n9ywbd	62	13	modified	modify	VBN
cord-264489-h1n9ywbd	62	14	PDB	PDB	NNP
cord-264489-h1n9ywbd	62	15	file	file	NN
cord-264489-h1n9ywbd	62	16	contained	contain	VBD
cord-264489-h1n9ywbd	62	17	the	the	DT
cord-264489-h1n9ywbd	62	18	predicted	predict	VBN
cord-264489-h1n9ywbd	62	19	hydrogen	hydrogen	NN
cord-264489-h1n9ywbd	62	20	atoms	atom	NNS
cord-264489-h1n9ywbd	62	21	coordinates	coordinate	VBZ
cord-264489-h1n9ywbd	62	22	.	.	.
cord-264489-h1n9ywbd	63	1	The	the	DT
cord-264489-h1n9ywbd	63	2	solvated	solvated	JJ
cord-264489-h1n9ywbd	63	3	and	and	CC
cord-264489-h1n9ywbd	63	4	neutralized	neutralize	VBD
cord-264489-h1n9ywbd	63	5	protein	protein	NN
cord-264489-h1n9ywbd	63	6	structures	structure	NNS
cord-264489-h1n9ywbd	63	7	were	be	VBD
cord-264489-h1n9ywbd	63	8	obtained	obtain	VBN
cord-264489-h1n9ywbd	63	9	using	use	VBG
cord-264489-h1n9ywbd	63	10	solvate	solvate	NN
cord-264489-h1n9ywbd	63	11	and	and	CC
cord-264489-h1n9ywbd	63	12	ionize	ionize	VB
cord-264489-h1n9ywbd	63	13	gui	gui	NN
cord-264489-h1n9ywbd	63	14	of	of	IN
cord-264489-h1n9ywbd	63	15	VMD	VMD	NNP
cord-264489-h1n9ywbd	63	16	,	,	,
cord-264489-h1n9ywbd	63	17	where	where	WRB
cord-264489-h1n9ywbd	63	18	a	a	DT
cord-264489-h1n9ywbd	63	19	0.15mol	0.15mol	CD
cord-264489-h1n9ywbd	63	20	/	/	SYM
cord-264489-h1n9ywbd	63	21	L	l	NN
cord-264489-h1n9ywbd	63	22	concentration	concentration	NN
cord-264489-h1n9ywbd	63	23	of	of	IN
cord-264489-h1n9ywbd	63	24	NaCl	NaCl	NNP
cord-264489-h1n9ywbd	63	25	was	be	VBD
cord-264489-h1n9ywbd	63	26	used	use	VBN
cord-264489-h1n9ywbd	63	27	for	for	IN
cord-264489-h1n9ywbd	63	28	system	system	NN
cord-264489-h1n9ywbd	63	29	neutralization	neutralization	NN
cord-264489-h1n9ywbd	63	30	.	.	.
cord-264489-h1n9ywbd	64	1	Energy	energy	NN
cord-264489-h1n9ywbd	64	2	minimization	minimization	NN
cord-264489-h1n9ywbd	64	3	for	for	IN
cord-264489-h1n9ywbd	64	4	the	the	DT
cord-264489-h1n9ywbd	64	5	system	system	NN
cord-264489-h1n9ywbd	64	6	was	be	VBD
cord-264489-h1n9ywbd	64	7	performed	perform	VBN
cord-264489-h1n9ywbd	64	8	in	in	IN
cord-264489-h1n9ywbd	64	9	10,000	10,000	CD
cord-264489-h1n9ywbd	64	10	steps	step	NNS
cord-264489-h1n9ywbd	64	11	using	use	VBG
cord-264489-h1n9ywbd	64	12	the	the	DT
cord-264489-h1n9ywbd	64	13	NPT	NPT	NNP
cord-264489-h1n9ywbd	64	14	ensemble	ensemble	NN
cord-264489-h1n9ywbd	64	15	.	.	.
cord-264489-h1n9ywbd	65	1	The	the	DT
cord-264489-h1n9ywbd	65	2	final	final	JJ
cord-264489-h1n9ywbd	65	3	production	production	NN
cord-264489-h1n9ywbd	65	4	run	run	NN
cord-264489-h1n9ywbd	65	5	was	be	VBD
cord-264489-h1n9ywbd	65	6	carried	carry	VBN
cord-264489-h1n9ywbd	65	7	out	out	RP
cord-264489-h1n9ywbd	65	8	for	for	IN
cord-264489-h1n9ywbd	65	9	20	20	CD
cord-264489-h1n9ywbd	65	10	ns	n	NNS
cord-264489-h1n9ywbd	65	11	at	at	IN
cord-264489-h1n9ywbd	65	12	298	298	CD
cord-264489-h1n9ywbd	65	13	K	k	NN
cord-264489-h1n9ywbd	65	14	using	use	VBG
cord-264489-h1n9ywbd	65	15	the	the	DT
cord-264489-h1n9ywbd	65	16	NVT	NVT	NNP
cord-264489-h1n9ywbd	65	17	ensemble	ensemble	NN
cord-264489-h1n9ywbd	65	18	and	and	CC
cord-264489-h1n9ywbd	65	19	employing	employ	VBG
cord-264489-h1n9ywbd	65	20	the	the	DT
cord-264489-h1n9ywbd	65	21	CHARMM	CHARMM	NNP
cord-264489-h1n9ywbd	65	22	force	force	NN
cord-264489-h1n9ywbd	65	23	field	field	NN
cord-264489-h1n9ywbd	65	24	.	.	.
cord-264489-h1n9ywbd	66	1	A	a	DT
cord-264489-h1n9ywbd	66	2	combined	combined	JJ
cord-264489-h1n9ywbd	66	3	version	version	NN
cord-264489-h1n9ywbd	66	4	of	of	IN
cord-264489-h1n9ywbd	66	5	CHARM22	CHARM22	NNP
cord-264489-h1n9ywbd	66	6	/	/	SYM
cord-264489-h1n9ywbd	66	7	CHARMM27	CHARMM27	NNP
cord-264489-h1n9ywbd	66	8	/	/	SYM
cord-264489-h1n9ywbd	66	9	CMAP	CMAP	NNP
cord-264489-h1n9ywbd	66	10	force	force	NN
cord-264489-h1n9ywbd	66	11	field	field	NN
cord-264489-h1n9ywbd	66	12	was	be	VBD
cord-264489-h1n9ywbd	66	13	used	use	VBN
cord-264489-h1n9ywbd	66	14	for	for	IN
cord-264489-h1n9ywbd	66	15	this	this	DT
cord-264489-h1n9ywbd	66	16	purpose	purpose	NN
cord-264489-h1n9ywbd	66	17	.	.	.
cord-264489-h1n9ywbd	67	1	CHARM22	CHARM22	NNP
cord-264489-h1n9ywbd	68	1	and	and	CC
cord-264489-h1n9ywbd	68	2	CHARMM27	CHARMM27	NNP
cord-264489-h1n9ywbd	68	3	provided	provide	VBD
cord-264489-h1n9ywbd	68	4	the	the	DT
cord-264489-h1n9ywbd	68	5	necessary	necessary	JJ
cord-264489-h1n9ywbd	68	6	parameter	parameter	NN
cord-264489-h1n9ywbd	68	7	files	file	NNS
cord-264489-h1n9ywbd	68	8	for	for	IN
cord-264489-h1n9ywbd	68	9	the	the	DT
cord-264489-h1n9ywbd	68	10	proteins	protein	NNS
cord-264489-h1n9ywbd	68	11	as	as	RB
cord-264489-h1n9ywbd	68	12	well	well	RB
cord-264489-h1n9ywbd	68	13	as	as	IN
cord-264489-h1n9ywbd	68	14	the	the	DT
cord-264489-h1n9ywbd	68	15	lipids	lipid	NNS
cord-264489-h1n9ywbd	68	16	.	.	.
cord-264489-h1n9ywbd	69	1	The	the	DT
cord-264489-h1n9ywbd	69	2	proteins	protein	NNS
cord-264489-h1n9ywbd	69	3	were	be	VBD
cord-264489-h1n9ywbd	69	4	subjected	subject	VBN
cord-264489-h1n9ywbd	69	5	to	to	IN
cord-264489-h1n9ywbd	69	6	phi	phi	NNP
cord-264489-h1n9ywbd	69	7	,	,	,
cord-264489-h1n9ywbd	69	8	psi	psi	NNP
cord-264489-h1n9ywbd	69	9	cross	cross	NNP
cord-264489-h1n9ywbd	69	10	term	term	NN
cord-264489-h1n9ywbd	69	11	map	map	NN
cord-264489-h1n9ywbd	69	12	(	(	-LRB-
cord-264489-h1n9ywbd	69	13	CMAP	CMAP	NNP
cord-264489-h1n9ywbd	69	14	)	)	-RRB-
cord-264489-h1n9ywbd	69	15	corrections	correction	NNS
cord-264489-h1n9ywbd	69	16	(	(	-LRB-
cord-264489-h1n9ywbd	69	17	a	a	DT
cord-264489-h1n9ywbd	69	18	built	build	VBN
cord-264489-h1n9ywbd	69	19	-	-	HYPH
cord-264489-h1n9ywbd	69	20	in	in	RP
cord-264489-h1n9ywbd	69	21	feature	feature	NN
cord-264489-h1n9ywbd	69	22	of	of	IN
cord-264489-h1n9ywbd	69	23	NAMD	NAMD	NNP
cord-264489-h1n9ywbd	69	24	plugin	plugin	NN
cord-264489-h1n9ywbd	69	25	gui	gui	NN
cord-264489-h1n9ywbd	69	26	)	)	-RRB-
cord-264489-h1n9ywbd	69	27	;	;	:
cord-264489-h1n9ywbd	69	28	these	these	DT
cord-264489-h1n9ywbd	69	29	force	force	NN
cord-264489-h1n9ywbd	69	30	field	field	NN
cord-264489-h1n9ywbd	69	31	parameter	parameter	NN
cord-264489-h1n9ywbd	69	32	files	file	NNS
cord-264489-h1n9ywbd	69	33	were	be	VBD
cord-264489-h1n9ywbd	69	34	necessary	necessary	JJ
cord-264489-h1n9ywbd	69	35	to	to	TO
cord-264489-h1n9ywbd	69	36	calculate	calculate	VB
cord-264489-h1n9ywbd	69	37	the	the	DT
cord-264489-h1n9ywbd	69	38	energies	energy	NNS
cord-264489-h1n9ywbd	69	39	.	.	.
cord-264489-h1n9ywbd	70	1	The	the	DT
cord-264489-h1n9ywbd	70	2	periodic	periodic	JJ
cord-264489-h1n9ywbd	70	3	boundary	boundary	JJ
cord-264489-h1n9ywbd	70	4	condition	condition	NN
cord-264489-h1n9ywbd	70	5	with	with	IN
cord-264489-h1n9ywbd	70	6	"	"	``
cord-264489-h1n9ywbd	70	7	Langevin	Langevin	NNP
cord-264489-h1n9ywbd	70	8	on	on	IN
cord-264489-h1n9ywbd	70	9	"	"	``
cord-264489-h1n9ywbd	70	10	control	control	NN
cord-264489-h1n9ywbd	70	11	was	be	VBD
cord-264489-h1n9ywbd	70	12	applied	apply	VBN
cord-264489-h1n9ywbd	70	13	in	in	IN
cord-264489-h1n9ywbd	70	14	each	each	DT
cord-264489-h1n9ywbd	70	15	case	case	NN
cord-264489-h1n9ywbd	70	16	,	,	,
cord-264489-h1n9ywbd	70	17	with	with	IN
cord-264489-h1n9ywbd	70	18	an	an	DT
cord-264489-h1n9ywbd	70	19	"	"	``
cord-264489-h1n9ywbd	70	20	active	active	JJ
cord-264489-h1n9ywbd	70	21	"	"	''
cord-264489-h1n9ywbd	70	22	setting	setting	NN
cord-264489-h1n9ywbd	70	23	of	of	IN
cord-264489-h1n9ywbd	70	24	particle	particle	NN
cord-264489-h1n9ywbd	70	25	mesh	mesh	NNP
cord-264489-h1n9ywbd	70	26	ewald	ewald	NNP
cord-264489-h1n9ywbd	70	27	(	(	-LRB-
cord-264489-h1n9ywbd	70	28	PME	PME	NNP
cord-264489-h1n9ywbd	70	29	)	)	-RRB-
cord-264489-h1n9ywbd	70	30	.	.	.
cord-264489-h1n9ywbd	71	1	The	the	DT
cord-264489-h1n9ywbd	71	2	Langevin	Langevin	NNP
cord-264489-h1n9ywbd	71	3	Damping	Damping	NNP
cord-264489-h1n9ywbd	71	4	was	be	VBD
cord-264489-h1n9ywbd	71	5	set	set	VBN
cord-264489-h1n9ywbd	71	6	to	to	IN
cord-264489-h1n9ywbd	71	7	1	1	CD
cord-264489-h1n9ywbd	71	8	.	.	.
cord-264489-h1n9ywbd	72	1	The	the	DT
cord-264489-h1n9ywbd	72	2	time	time	NN
cord-264489-h1n9ywbd	72	3	steps	step	NNS
cord-264489-h1n9ywbd	72	4	were	be	VBD
cord-264489-h1n9ywbd	72	5	set	set	VBN
cord-264489-h1n9ywbd	72	6	to	to	IN
cord-264489-h1n9ywbd	72	7	1	1	CD
cord-264489-h1n9ywbd	72	8	femtosecond	femtosecond	NN
cord-264489-h1n9ywbd	72	9	(	(	-LRB-
cord-264489-h1n9ywbd	72	10	fs	fs	NNP
cord-264489-h1n9ywbd	72	11	)	)	-RRB-
cord-264489-h1n9ywbd	72	12	,	,	,
cord-264489-h1n9ywbd	72	13	with	with	IN
cord-264489-h1n9ywbd	72	14	20	20	CD
cord-264489-h1n9ywbd	72	15	steps	step	NNS
cord-264489-h1n9ywbd	72	16	per	per	IN
cord-264489-h1n9ywbd	72	17	cycle	cycle	NN
cord-264489-h1n9ywbd	72	18	selected	select	VBN
cord-264489-h1n9ywbd	72	19	.	.	.
cord-264489-h1n9ywbd	73	1	For	for	IN
cord-264489-h1n9ywbd	73	2	the	the	DT
cord-264489-h1n9ywbd	73	3	basic	basic	JJ
cord-264489-h1n9ywbd	73	4	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	73	5	,	,	,
cord-264489-h1n9ywbd	73	6	the	the	DT
cord-264489-h1n9ywbd	73	7	dielectric	dielectric	NN
cord-264489-h1n9ywbd	73	8	value	value	NN
cord-264489-h1n9ywbd	73	9	was	be	VBD
cord-264489-h1n9ywbd	73	10	set	set	VBN
cord-264489-h1n9ywbd	73	11	to	to	IN
cord-264489-h1n9ywbd	73	12	1.0	1.0	CD
cord-264489-h1n9ywbd	73	13	.	.	.
cord-264489-h1n9ywbd	74	1	The	the	DT
cord-264489-h1n9ywbd	74	2	periodic	periodic	JJ
cord-264489-h1n9ywbd	74	3	cell	cell	NN
cord-264489-h1n9ywbd	74	4	basis	basis	NN
cord-264489-h1n9ywbd	74	5	and	and	CC
cord-264489-h1n9ywbd	74	6	periodic	periodic	JJ
cord-264489-h1n9ywbd	74	7	cell	cell	NN
cord-264489-h1n9ywbd	74	8	center	center	NN
cord-264489-h1n9ywbd	74	9	were	be	VBD
cord-264489-h1n9ywbd	74	10	selected	select	VBN
cord-264489-h1n9ywbd	74	11	according	accord	VBG
cord-264489-h1n9ywbd	74	12	to	to	IN
cord-264489-h1n9ywbd	74	13	the	the	DT
cord-264489-h1n9ywbd	74	14	PDB	PDB	NNP
cord-264489-h1n9ywbd	74	15	coordinates	coordinate	VBZ
cord-264489-h1n9ywbd	74	16	.	.	.
cord-264489-h1n9ywbd	75	1	The	the	DT
cord-264489-h1n9ywbd	75	2	time	time	NN
cord-264489-h1n9ywbd	75	3	frames	frame	NNS
cord-264489-h1n9ywbd	75	4	of	of	IN
cord-264489-h1n9ywbd	75	5	each	each	DT
cord-264489-h1n9ywbd	75	6	system	system	NN
cord-264489-h1n9ywbd	75	7	were	be	VBD
cord-264489-h1n9ywbd	75	8	saved	save	VBN
cord-264489-h1n9ywbd	75	9	as	as	IN
cord-264489-h1n9ywbd	75	10	"	"	``
cord-264489-h1n9ywbd	75	11	DCD	DCD	NNP
cord-264489-h1n9ywbd	75	12	"	"	''
cord-264489-h1n9ywbd	75	13	files	file	NNS
cord-264489-h1n9ywbd	75	14	.	.	.
cord-264489-h1n9ywbd	76	1	The	the	DT
cord-264489-h1n9ywbd	76	2	output	output	NN
cord-264489-h1n9ywbd	76	3	parameters	parameter	NNS
cord-264489-h1n9ywbd	76	4	,	,	,
cord-264489-h1n9ywbd	76	5	like	like	IN
cord-264489-h1n9ywbd	76	6	DCD	DCD	NNP
cord-264489-h1n9ywbd	76	7	/	/	SYM
cord-264489-h1n9ywbd	76	8	XST	XST	NNP
cord-264489-h1n9ywbd	76	9	output	output	NN
cord-264489-h1n9ywbd	76	10	frequency	frequency	NN
cord-264489-h1n9ywbd	76	11	,	,	,
cord-264489-h1n9ywbd	76	12	energy	energy	NN
cord-264489-h1n9ywbd	76	13	output	output	NN
cord-264489-h1n9ywbd	76	14	frequency	frequency	NN
cord-264489-h1n9ywbd	76	15	and	and	CC
cord-264489-h1n9ywbd	76	16	restart	restart	VB
cord-264489-h1n9ywbd	76	17	file	file	NN
cord-264489-h1n9ywbd	76	18	frequency	frequency	NN
cord-264489-h1n9ywbd	76	19	,	,	,
cord-264489-h1n9ywbd	76	20	were	be	VBD
cord-264489-h1n9ywbd	76	21	chosen	choose	VBN
cord-264489-h1n9ywbd	76	22	according	accord	VBG
cord-264489-h1n9ywbd	76	23	to	to	IN
cord-264489-h1n9ywbd	76	24	system	system	NN
cord-264489-h1n9ywbd	76	25	specifications	specification	NNS
cord-264489-h1n9ywbd	76	26	.	.	.
cord-264489-h1n9ywbd	77	1	Most	Most	JJS
cord-264489-h1n9ywbd	77	2	of	of	IN
cord-264489-h1n9ywbd	77	3	these	these	DT
cord-264489-h1n9ywbd	77	4	parameters	parameter	NNS
cord-264489-h1n9ywbd	77	5	were	be	VBD
cord-264489-h1n9ywbd	77	6	kept	keep	VBN
cord-264489-h1n9ywbd	77	7	at	at	IN
cord-264489-h1n9ywbd	77	8	their	-PRON-	PRP$
cord-264489-h1n9ywbd	77	9	default	default	NN
cord-264489-h1n9ywbd	77	10	values	value	NNS
cord-264489-h1n9ywbd	77	11	incorporated	incorporate	VBN
cord-264489-h1n9ywbd	77	12	in	in	IN
cord-264489-h1n9ywbd	77	13	the	the	DT
cord-264489-h1n9ywbd	77	14	NAMD	NAMD	NNP
cord-264489-h1n9ywbd	77	15	gui	gui	NN
cord-264489-h1n9ywbd	77	16	.	.	.
cord-264489-h1n9ywbd	78	1	This	this	DT
cord-264489-h1n9ywbd	78	2	simulation	simulation	NN
cord-264489-h1n9ywbd	78	3	approach	approach	NN
cord-264489-h1n9ywbd	78	4	is	be	VBZ
cord-264489-h1n9ywbd	78	5	based	base	VBN
cord-264489-h1n9ywbd	78	6	on	on	IN
cord-264489-h1n9ywbd	78	7	the	the	DT
cord-264489-h1n9ywbd	78	8	conformational	conformational	JJ
cord-264489-h1n9ywbd	78	9	sampling	sampling	NN
cord-264489-h1n9ywbd	78	10	of	of	IN
cord-264489-h1n9ywbd	78	11	the	the	DT
cord-264489-h1n9ywbd	78	12	predominant	predominant	NN
cord-264489-h1n9ywbd	78	13	(	(	-LRB-
cord-264489-h1n9ywbd	78	14	especially	especially	RB
cord-264489-h1n9ywbd	78	15	early	early	JJ
cord-264489-h1n9ywbd	78	16	-	-	HYPH
cord-264489-h1n9ywbd	78	17	stage	stage	NN
cord-264489-h1n9ywbd	78	18	)	)	-RRB-
cord-264489-h1n9ywbd	79	1	structural	structural	JJ
cord-264489-h1n9ywbd	79	2	changes	change	NNS
cord-264489-h1n9ywbd	79	3	of	of	IN
cord-264489-h1n9ywbd	79	4	the	the	DT
cord-264489-h1n9ywbd	79	5	four	four	CD
cord-264489-h1n9ywbd	79	6	systems	system	NNS
cord-264489-h1n9ywbd	79	7	studied	study	VBN
cord-264489-h1n9ywbd	79	8	here	here	RB
cord-264489-h1n9ywbd	80	1	(	(	-LRB-
cord-264489-h1n9ywbd	80	2	Chhatbar	Chhatbar	NNP
cord-264489-h1n9ywbd	80	3	et	et	FW
cord-264489-h1n9ywbd	80	4	al	al	NNP
cord-264489-h1n9ywbd	80	5	.	.	.
cord-264489-h1n9ywbd	81	1	2019	2019	CD
cord-264489-h1n9ywbd	81	2	;	;	:
cord-264489-h1n9ywbd	81	3	Dimić	Dimić	NNP
cord-264489-h1n9ywbd	81	4	et	et	NNP
cord-264489-h1n9ywbd	81	5	al	al	NNP
cord-264489-h1n9ywbd	81	6	.	.	NNP
cord-264489-h1n9ywbd	81	7	2020	2020	CD
cord-264489-h1n9ywbd	81	8	)	)	-RRB-
cord-264489-h1n9ywbd	81	9	.	.	.
cord-264489-h1n9ywbd	82	1	The	the	DT
cord-264489-h1n9ywbd	82	2	computational	computational	JJ
cord-264489-h1n9ywbd	82	3	protocol	protocol	NN
cord-264489-h1n9ywbd	82	4	was	be	VBD
cord-264489-h1n9ywbd	82	5	designed	design	VBN
cord-264489-h1n9ywbd	82	6	to	to	TO
cord-264489-h1n9ywbd	82	7	obtain	obtain	VB
cord-264489-h1n9ywbd	82	8	the	the	DT
cord-264489-h1n9ywbd	82	9	basic	basic	JJ
cord-264489-h1n9ywbd	82	10	frameworks	framework	NNS
cord-264489-h1n9ywbd	82	11	for	for	IN
cord-264489-h1n9ywbd	82	12	the	the	DT
cord-264489-h1n9ywbd	82	13	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	82	14	ligand	ligand	NN
cord-264489-h1n9ywbd	82	15	and	and	CC
cord-264489-h1n9ywbd	82	16	the	the	DT
cord-264489-h1n9ywbd	82	17	ligand	ligand	NN
cord-264489-h1n9ywbd	82	18	bound	bind	VBN
cord-264489-h1n9ywbd	82	19	holo	holo	NN
cord-264489-h1n9ywbd	82	20	structures	structure	NNS
cord-264489-h1n9ywbd	82	21	.	.	.
cord-264489-h1n9ywbd	83	1	Additional	additional	JJ
cord-264489-h1n9ywbd	83	2	computational	computational	JJ
cord-264489-h1n9ywbd	83	3	details	detail	NNS
cord-264489-h1n9ywbd	83	4	of	of	IN
cord-264489-h1n9ywbd	83	5	the	the	DT
cord-264489-h1n9ywbd	83	6	present	present	JJ
cord-264489-h1n9ywbd	83	7	work	work	NN
cord-264489-h1n9ywbd	83	8	have	have	VBP
cord-264489-h1n9ywbd	83	9	been	be	VBN
cord-264489-h1n9ywbd	83	10	described	describe	VBN
cord-264489-h1n9ywbd	83	11	elsewhere	elsewhere	RB
cord-264489-h1n9ywbd	84	1	(	(	-LRB-
cord-264489-h1n9ywbd	84	2	Roy	Roy	NNP
cord-264489-h1n9ywbd	84	3	2016a	2016a	CD
cord-264489-h1n9ywbd	84	4	(	(	-LRB-
cord-264489-h1n9ywbd	84	5	Roy	Roy	NNP
cord-264489-h1n9ywbd	84	6	,	,	,
cord-264489-h1n9ywbd	84	7	2016b	2016b	CD
cord-264489-h1n9ywbd	84	8	(	(	-LRB-
cord-264489-h1n9ywbd	84	9	Roy	Roy	NNP
cord-264489-h1n9ywbd	84	10	,	,	,
cord-264489-h1n9ywbd	84	11	2017	2017	CD
cord-264489-h1n9ywbd	84	12	(	(	-LRB-
cord-264489-h1n9ywbd	84	13	Roy	Roy	NNP
cord-264489-h1n9ywbd	84	14	,	,	,
cord-264489-h1n9ywbd	84	15	2019a	2019a	CD
cord-264489-h1n9ywbd	84	16	(	(	-LRB-
cord-264489-h1n9ywbd	84	17	Roy	Roy	NNP
cord-264489-h1n9ywbd	84	18	,	,	,
cord-264489-h1n9ywbd	84	19	2019b	2019b	CD
cord-264489-h1n9ywbd	84	20	(	(	-LRB-
cord-264489-h1n9ywbd	84	21	Roy	Roy	NNP
cord-264489-h1n9ywbd	84	22	,	,	,
cord-264489-h1n9ywbd	84	23	2020	2020	CD
cord-264489-h1n9ywbd	84	24	.	.	.
cord-264489-h1n9ywbd	85	1	Table	table	NN
cord-264489-h1n9ywbd	85	2	S1	S1	NNP
cord-264489-h1n9ywbd	85	3	has	have	VBZ
cord-264489-h1n9ywbd	85	4	been	be	VBN
cord-264489-h1n9ywbd	85	5	included	include	VBN
cord-264489-h1n9ywbd	85	6	in	in	IN
cord-264489-h1n9ywbd	85	7	the	the	DT
cord-264489-h1n9ywbd	85	8	Supplementary	Supplementary	NNP
cord-264489-h1n9ywbd	85	9	Data	Data	NNP
cord-264489-h1n9ywbd	85	10	(	(	-LRB-
cord-264489-h1n9ywbd	85	11	SD	SD	NNP
cord-264489-h1n9ywbd	85	12	)	)	-RRB-
cord-264489-h1n9ywbd	85	13	to	to	TO
cord-264489-h1n9ywbd	85	14	list	list	VB
cord-264489-h1n9ywbd	85	15	the	the	DT
cord-264489-h1n9ywbd	85	16	abbreviations	abbreviation	NNS
cord-264489-h1n9ywbd	85	17	of	of	IN
cord-264489-h1n9ywbd	85	18	Fig.1	fig.1	NN
cord-264489-h1n9ywbd	85	19	.	.	.
cord-264489-h1n9ywbd	86	1	The	the	DT
cord-264489-h1n9ywbd	86	2	PPI	PPI	NNP
cord-264489-h1n9ywbd	86	3	is	be	VBZ
cord-264489-h1n9ywbd	86	4	one	one	CD
cord-264489-h1n9ywbd	86	5	of	of	IN
cord-264489-h1n9ywbd	86	6	the	the	DT
cord-264489-h1n9ywbd	86	7	most	most	RBS
cord-264489-h1n9ywbd	86	8	valuable	valuable	JJ
cord-264489-h1n9ywbd	86	9	tools	tool	NNS
cord-264489-h1n9ywbd	86	10	for	for	IN
cord-264489-h1n9ywbd	86	11	identifying	identify	VBG
cord-264489-h1n9ywbd	86	12	the	the	DT
cord-264489-h1n9ywbd	86	13	ligand	ligand	NN
cord-264489-h1n9ywbd	86	14	-	-	HYPH
cord-264489-h1n9ywbd	86	15	receptor	receptor	NN
cord-264489-h1n9ywbd	86	16	interactions	interaction	NNS
cord-264489-h1n9ywbd	86	17	and	and	CC
cord-264489-h1n9ywbd	86	18	signaling	signal	VBG
cord-264489-h1n9ywbd	86	19	cascades	cascade	NNS
cord-264489-h1n9ywbd	87	1	(	(	-LRB-
cord-264489-h1n9ywbd	87	2	Jiang	Jiang	NNP
cord-264489-h1n9ywbd	87	3	et	et	FW
cord-264489-h1n9ywbd	87	4	al	al	NNP
cord-264489-h1n9ywbd	87	5	.	.	.
cord-264489-h1n9ywbd	87	6	2015	2015	CD
cord-264489-h1n9ywbd	88	1	;	;	:
cord-264489-h1n9ywbd	88	2	Wang	Wang	NNP
cord-264489-h1n9ywbd	88	3	et	et	NNP
cord-264489-h1n9ywbd	88	4	al	al	NNP
cord-264489-h1n9ywbd	88	5	.	.	.
cord-264489-h1n9ywbd	88	6	2018	2018	CD
cord-264489-h1n9ywbd	88	7	)	)	-RRB-
cord-264489-h1n9ywbd	88	8	.	.	.
cord-264489-h1n9ywbd	89	1	The	the	DT
cord-264489-h1n9ywbd	89	2	results	result	NNS
cord-264489-h1n9ywbd	89	3	have	have	VBP
cord-264489-h1n9ywbd	89	4	been	be	VBN
cord-264489-h1n9ywbd	89	5	generated	generate	VBN
cord-264489-h1n9ywbd	89	6	by	by	IN
cord-264489-h1n9ywbd	89	7	Cytoscape	Cytoscape	NNP
cord-264489-h1n9ywbd	89	8	,	,	,
cord-264489-h1n9ywbd	89	9	on	on	IN
cord-264489-h1n9ywbd	89	10	the	the	DT
cord-264489-h1n9ywbd	89	11	basis	basis	NN
cord-264489-h1n9ywbd	89	12	of	of	IN
cord-264489-h1n9ywbd	89	13	experimental	experimental	JJ
cord-264489-h1n9ywbd	89	14	data	datum	NNS
cord-264489-h1n9ywbd	89	15	,	,	,
cord-264489-h1n9ywbd	89	16	as	as	RB
cord-264489-h1n9ywbd	89	17	well	well	RB
cord-264489-h1n9ywbd	89	18	as	as	IN
cord-264489-h1n9ywbd	89	19	manually	manually	RB
cord-264489-h1n9ywbd	89	20	curated	curate	VBN
cord-264489-h1n9ywbd	89	21	results	result	NNS
cord-264489-h1n9ywbd	89	22	obtained	obtain	VBN
cord-264489-h1n9ywbd	89	23	using	use	VBG
cord-264489-h1n9ywbd	89	24	the	the	DT
cord-264489-h1n9ywbd	89	25	Mentha	Mentha	NNP
cord-264489-h1n9ywbd	89	26	database	database	NN
cord-264489-h1n9ywbd	89	27	(	(	-LRB-
cord-264489-h1n9ywbd	89	28	Calderone	Calderone	NNP
cord-264489-h1n9ywbd	89	29	et	et	NNP
cord-264489-h1n9ywbd	89	30	al	al	NNP
cord-264489-h1n9ywbd	89	31	.	.	NNP
cord-264489-h1n9ywbd	89	32	2013	2013	CD
cord-264489-h1n9ywbd	89	33	)	)	-RRB-
cord-264489-h1n9ywbd	89	34	.	.	.
cord-264489-h1n9ywbd	90	1	Mentha	Mentha	NNP
cord-264489-h1n9ywbd	90	2	compiles	compile	VBZ
cord-264489-h1n9ywbd	90	3	the	the	DT
cord-264489-h1n9ywbd	90	4	proteins	protein	NNS
cord-264489-h1n9ywbd	90	5	'	'	POS
cord-264489-h1n9ywbd	90	6	key	key	JJ
cord-264489-h1n9ywbd	90	7	interaction	interaction	NN
cord-264489-h1n9ywbd	90	8	data	datum	NNS
cord-264489-h1n9ywbd	90	9	J	J	NNP
cord-264489-h1n9ywbd	90	10	o	o	NN
cord-264489-h1n9ywbd	90	11	u	u	NN
cord-264489-h1n9ywbd	90	12	r	r	NN
cord-264489-h1n9ywbd	90	13	n	n	NN
cord-264489-h1n9ywbd	90	14	a	a	DT
cord-264489-h1n9ywbd	90	15	l	l	NN
cord-264489-h1n9ywbd	90	16	P	p	NN
cord-264489-h1n9ywbd	90	17	r	r	NN
cord-264489-h1n9ywbd	90	18	e	e	NN
cord-264489-h1n9ywbd	90	19	-p	-p	NN
cord-264489-h1n9ywbd	91	1	r	r	NNP
cord-264489-h1n9ywbd	91	2	o	o	NN
cord-264489-h1n9ywbd	91	3	o	o	NN
cord-264489-h1n9ywbd	91	4	f	f	NN
cord-264489-h1n9ywbd	91	5	collected	collect	VBN
cord-264489-h1n9ywbd	91	6	by	by	IN
cord-264489-h1n9ywbd	91	7	International	International	NNP
cord-264489-h1n9ywbd	91	8	Molecular	Molecular	NNP
cord-264489-h1n9ywbd	91	9	Exchange	Exchange	NNP
cord-264489-h1n9ywbd	91	10	(	(	-LRB-
cord-264489-h1n9ywbd	91	11	IMEx	IMEx	NNP
cord-264489-h1n9ywbd	91	12	)	)	-RRB-
cord-264489-h1n9ywbd	91	13	databases	database	NNS
cord-264489-h1n9ywbd	91	14	(	(	-LRB-
cord-264489-h1n9ywbd	91	15	Orchard	Orchard	NNP
cord-264489-h1n9ywbd	91	16	et	et	NNP
cord-264489-h1n9ywbd	91	17	al	al	NNP
cord-264489-h1n9ywbd	91	18	.	.	NNP
cord-264489-h1n9ywbd	91	19	2012	2012	CD
cord-264489-h1n9ywbd	91	20	)	)	-RRB-
cord-264489-h1n9ywbd	91	21	and	and	CC
cord-264489-h1n9ywbd	91	22	analyzes	analyze	VBZ
cord-264489-h1n9ywbd	91	23	the	the	DT
cord-264489-h1n9ywbd	91	24	experimental	experimental	JJ
cord-264489-h1n9ywbd	91	25	data	datum	NNS
cord-264489-h1n9ywbd	91	26	with	with	IN
cord-264489-h1n9ywbd	91	27	a	a	DT
cord-264489-h1n9ywbd	91	28	thorough	thorough	JJ
cord-264489-h1n9ywbd	91	29	annotation	annotation	NN
cord-264489-h1n9ywbd	91	30	.	.	.
cord-264489-h1n9ywbd	92	1	The	the	DT
cord-264489-h1n9ywbd	92	2	interactions	interaction	NNS
cord-264489-h1n9ywbd	92	3	considered	consider	VBN
cord-264489-h1n9ywbd	92	4	here	here	RB
cord-264489-h1n9ywbd	92	5	are	be	VBP
cord-264489-h1n9ywbd	92	6	dominated	dominate	VBN
cord-264489-h1n9ywbd	92	7	by	by	IN
cord-264489-h1n9ywbd	92	8	physical	physical	JJ
cord-264489-h1n9ywbd	92	9	association	association	NNP
cord-264489-h1n9ywbd	92	10	(	(	-LRB-
cord-264489-h1n9ywbd	92	11	as	as	IN
cord-264489-h1n9ywbd	92	12	those	those	DT
cord-264489-h1n9ywbd	92	13	studied	study	VBN
cord-264489-h1n9ywbd	92	14	in	in	IN
cord-264489-h1n9ywbd	92	15	affinity	affinity	NN
cord-264489-h1n9ywbd	92	16	chromatography	chromatography	NN
cord-264489-h1n9ywbd	92	17	,	,	,
cord-264489-h1n9ywbd	92	18	two	two	CD
cord-264489-h1n9ywbd	92	19	hybrid	hybrid	JJ
cord-264489-h1n9ywbd	92	20	array	array	NN
cord-264489-h1n9ywbd	92	21	and	and	CC
cord-264489-h1n9ywbd	92	22	two	two	CD
cord-264489-h1n9ywbd	92	23	hybrid	hybrid	JJ
cord-264489-h1n9ywbd	92	24	prey	prey	NN
cord-264489-h1n9ywbd	92	25	pooling	pooling	NN
cord-264489-h1n9ywbd	92	26	)	)	-RRB-
cord-264489-h1n9ywbd	92	27	,	,	,
cord-264489-h1n9ywbd	92	28	direct	direct	JJ
cord-264489-h1n9ywbd	92	29	interactions	interaction	NNS
cord-264489-h1n9ywbd	92	30	(	(	-LRB-
cord-264489-h1n9ywbd	92	31	pull	pull	VB
cord-264489-h1n9ywbd	92	32	down	down	RP
cord-264489-h1n9ywbd	92	33	,	,	,
cord-264489-h1n9ywbd	92	34	cross	cross	NN
cord-264489-h1n9ywbd	92	35	-	-	JJ
cord-264489-h1n9ywbd	92	36	linking	link	VBG
cord-264489-h1n9ywbd	92	37	/	/	SYM
cord-264489-h1n9ywbd	92	38	molecular	molecular	JJ
cord-264489-h1n9ywbd	92	39	sieving	sieving	NN
cord-264489-h1n9ywbd	92	40	/	/	SYM
cord-264489-h1n9ywbd	92	41	Xray	Xray	NNP
cord-264489-h1n9ywbd	92	42	crystallography	crystallography	NN
cord-264489-h1n9ywbd	92	43	/	/	SYM
cord-264489-h1n9ywbd	92	44	enzymatic	enzymatic	JJ
cord-264489-h1n9ywbd	92	45	study	study	NN
cord-264489-h1n9ywbd	92	46	and	and	CC
cord-264489-h1n9ywbd	92	47	two	two	CD
cord-264489-h1n9ywbd	92	48	hybrid	hybrid	NN
cord-264489-h1n9ywbd	92	49	)	)	-RRB-
cord-264489-h1n9ywbd	92	50	,	,	,
cord-264489-h1n9ywbd	92	51	physical	physical	JJ
cord-264489-h1n9ywbd	92	52	interactions	interaction	NNS
cord-264489-h1n9ywbd	92	53	(	(	-LRB-
cord-264489-h1n9ywbd	92	54	biochemical	biochemical	JJ
cord-264489-h1n9ywbd	92	55	)	)	-RRB-
cord-264489-h1n9ywbd	92	56	and	and	CC
cord-264489-h1n9ywbd	92	57	antitag	antitag	NN
cord-264489-h1n9ywbd	92	58	co	co	NN
cord-264489-h1n9ywbd	92	59	-	-	NN
cord-264489-h1n9ywbd	92	60	immunoprecipitation	immunoprecipitation	JJ
cord-264489-h1n9ywbd	92	61	.	.	.
cord-264489-h1n9ywbd	93	1	The	the	DT
cord-264489-h1n9ywbd	93	2	confidence	confidence	NN
cord-264489-h1n9ywbd	93	3	scores	score	NNS
cord-264489-h1n9ywbd	93	4	are	be	VBP
cord-264489-h1n9ywbd	93	5	based	base	VBN
cord-264489-h1n9ywbd	93	6	on	on	IN
cord-264489-h1n9ywbd	93	7	a	a	DT
cord-264489-h1n9ywbd	93	8	scale	scale	NN
cord-264489-h1n9ywbd	93	9	of	of	IN
cord-264489-h1n9ywbd	93	10	0	0	CD
cord-264489-h1n9ywbd	93	11	to	to	IN
cord-264489-h1n9ywbd	93	12	1	1	CD
cord-264489-h1n9ywbd	93	13	where	where	WRB
cord-264489-h1n9ywbd	93	14	these	these	DT
cord-264489-h1n9ywbd	93	15	values	value	NNS
cord-264489-h1n9ywbd	93	16	reflect	reflect	VBP
cord-264489-h1n9ywbd	93	17	the	the	DT
cord-264489-h1n9ywbd	93	18	number	number	NN
cord-264489-h1n9ywbd	93	19	of	of	IN
cord-264489-h1n9ywbd	93	20	functional	functional	JJ
cord-264489-h1n9ywbd	93	21	PPIs	ppi	NNS
cord-264489-h1n9ywbd	93	22	curated	curate	VBN
cord-264489-h1n9ywbd	93	23	by	by	IN
cord-264489-h1n9ywbd	93	24	experimental	experimental	JJ
cord-264489-h1n9ywbd	93	25	procedures	procedure	NNS
cord-264489-h1n9ywbd	93	26	as	as	RB
cord-264489-h1n9ywbd	93	27	well	well	RB
cord-264489-h1n9ywbd	93	28	as	as	IN
cord-264489-h1n9ywbd	93	29	based	base	VBN
cord-264489-h1n9ywbd	93	30	on	on	IN
cord-264489-h1n9ywbd	93	31	data	datum	NNS
cord-264489-h1n9ywbd	93	32	from	from	IN
cord-264489-h1n9ywbd	93	33	scientific	scientific	JJ
cord-264489-h1n9ywbd	93	34	literature	literature	NN
cord-264489-h1n9ywbd	93	35	.	.	.
cord-264489-h1n9ywbd	94	1	Nonetheless	nonetheless	RB
cord-264489-h1n9ywbd	94	2	there	there	EX
cord-264489-h1n9ywbd	94	3	is	be	VBZ
cord-264489-h1n9ywbd	94	4	always	always	RB
cord-264489-h1n9ywbd	94	5	a	a	DT
cord-264489-h1n9ywbd	94	6	possibility	possibility	NN
cord-264489-h1n9ywbd	94	7	that	that	IN
cord-264489-h1n9ywbd	94	8	a	a	DT
cord-264489-h1n9ywbd	94	9	few	few	JJ
cord-264489-h1n9ywbd	94	10	interactions	interaction	NNS
cord-264489-h1n9ywbd	94	11	may	may	MD
cord-264489-h1n9ywbd	94	12	be	be	VB
cord-264489-h1n9ywbd	94	13	absent	absent	JJ
cord-264489-h1n9ywbd	94	14	.	.	.
cord-264489-h1n9ywbd	95	1	The	the	DT
cord-264489-h1n9ywbd	95	2	score	score	NN
cord-264489-h1n9ywbd	95	3	between	between	IN
cord-264489-h1n9ywbd	95	4	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	95	5	and	and	CC
cord-264489-h1n9ywbd	95	6	IL-18R1	il-18r1	CD
cord-264489-h1n9ywbd	95	7	interaction	interaction	NN
cord-264489-h1n9ywbd	95	8	is	be	VBZ
cord-264489-h1n9ywbd	95	9	0.539	0.539	CD
cord-264489-h1n9ywbd	95	10	,	,	,
cord-264489-h1n9ywbd	95	11	which	which	WDT
cord-264489-h1n9ywbd	95	12	is	be	VBZ
cord-264489-h1n9ywbd	95	13	slightly	slightly	RB
cord-264489-h1n9ywbd	95	14	higher	high	JJR
cord-264489-h1n9ywbd	95	15	than	than	IN
cord-264489-h1n9ywbd	95	16	the	the	DT
cord-264489-h1n9ywbd	95	17	usual	usual	JJ
cord-264489-h1n9ywbd	95	18	upper	upper	JJ
cord-264489-h1n9ywbd	95	19	bound	bind	VBN
cord-264489-h1n9ywbd	95	20	of	of	IN
cord-264489-h1n9ywbd	95	21	a	a	DT
cord-264489-h1n9ywbd	95	22	"	"	``
cord-264489-h1n9ywbd	95	23	medium	medium	JJ
cord-264489-h1n9ywbd	95	24	"	"	''
cord-264489-h1n9ywbd	95	25	range	range	NN
cord-264489-h1n9ywbd	95	26	.	.	.
cord-264489-h1n9ywbd	96	1	The	the	DT
cord-264489-h1n9ywbd	96	2	score	score	NN
cord-264489-h1n9ywbd	96	3	near	near	IN
cord-264489-h1n9ywbd	96	4	the	the	DT
cord-264489-h1n9ywbd	96	5	range	range	NN
cord-264489-h1n9ywbd	96	6	of	of	IN
cord-264489-h1n9ywbd	96	7	1	1	CD
cord-264489-h1n9ywbd	96	8	denotes	denote	VBZ
cord-264489-h1n9ywbd	96	9	many	many	JJ
cord-264489-h1n9ywbd	96	10	PPIs	ppi	NNS
cord-264489-h1n9ywbd	96	11	as	as	IN
cord-264489-h1n9ywbd	96	12	published	publish	VBN
cord-264489-h1n9ywbd	96	13	in	in	IN
cord-264489-h1n9ywbd	96	14	scientific	scientific	JJ
cord-264489-h1n9ywbd	96	15	literature	literature	NN
cord-264489-h1n9ywbd	96	16	whereas	whereas	IN
cord-264489-h1n9ywbd	96	17	lower	low	JJR
cord-264489-h1n9ywbd	96	18	range	range	NN
cord-264489-h1n9ywbd	96	19	represents	represent	VBZ
cord-264489-h1n9ywbd	96	20	fewer	few	JJR
cord-264489-h1n9ywbd	96	21	experimental	experimental	JJ
cord-264489-h1n9ywbd	96	22	processes	process	NNS
cord-264489-h1n9ywbd	96	23	.	.	.
cord-264489-h1n9ywbd	97	1	The	the	DT
cord-264489-h1n9ywbd	97	2	PPIs	ppi	NNS
cord-264489-h1n9ywbd	97	3	identified	identify	VBN
cord-264489-h1n9ywbd	97	4	between	between	IN
cord-264489-h1n9ywbd	97	5	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	97	6	and	and	CC
cord-264489-h1n9ywbd	97	7	IL-18R1	IL-18R1	NNP
cord-264489-h1n9ywbd	97	8	are	be	VBP
cord-264489-h1n9ywbd	97	9	primarily	primarily	RB
cord-264489-h1n9ywbd	97	10	of	of	IN
cord-264489-h1n9ywbd	97	11	physical	physical	JJ
cord-264489-h1n9ywbd	97	12	/	/	SYM
cord-264489-h1n9ywbd	97	13	biochemical	biochemical	JJ
cord-264489-h1n9ywbd	97	14	origins	origin	NNS
cord-264489-h1n9ywbd	97	15	.	.	.
cord-264489-h1n9ywbd	98	1	The	the	DT
cord-264489-h1n9ywbd	98	2	high	high	JJ
cord-264489-h1n9ywbd	98	3	affinity	affinity	NN
cord-264489-h1n9ywbd	98	4	signaling	signal	VBG
cord-264489-h1n9ywbd	99	1	complex	complex	JJ
cord-264489-h1n9ywbd	99	2	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	99	3	/	/	SYM
cord-264489-h1n9ywbd	99	4	IL-18R	IL-18R	-LRB-
cord-264489-h1n9ywbd	99	5	initially	initially	RB
cord-264489-h1n9ywbd	99	6	activates	activate	VBZ
cord-264489-h1n9ywbd	99	7	toll	toll	NN
cord-264489-h1n9ywbd	99	8	like	like	IN
cord-264489-h1n9ywbd	99	9	receptor	receptor	NN
cord-264489-h1n9ywbd	99	10	(	(	-LRB-
cord-264489-h1n9ywbd	99	11	TLR	TLR	NNP
cord-264489-h1n9ywbd	99	12	)	)	-RRB-
cord-264489-h1n9ywbd	99	13	domains	domain	NNS
cord-264489-h1n9ywbd	99	14	,	,	,
cord-264489-h1n9ywbd	99	15	which	which	WDT
cord-264489-h1n9ywbd	99	16	,	,	,
cord-264489-h1n9ywbd	99	17	via	via	IN
cord-264489-h1n9ywbd	99	18	the	the	DT
cord-264489-h1n9ywbd	99	19	recruitment	recruitment	NN
cord-264489-h1n9ywbd	99	20	of	of	IN
cord-264489-h1n9ywbd	99	21	certain	certain	JJ
cord-264489-h1n9ywbd	99	22	adaptor	adaptor	NN
cord-264489-h1n9ywbd	99	23	and	and	CC
cord-264489-h1n9ywbd	99	24	recruiter	recruiter	NN
cord-264489-h1n9ywbd	99	25	molecules	molecule	NNS
cord-264489-h1n9ywbd	99	26	,	,	,
cord-264489-h1n9ywbd	99	27	ultimately	ultimately	RB
cord-264489-h1n9ywbd	99	28	trigger	trigger	VBP
cord-264489-h1n9ywbd	99	29	the	the	DT
cord-264489-h1n9ywbd	99	30	NF	NF	NNP
cord-264489-h1n9ywbd	99	31	and	and	CC
cord-264489-h1n9ywbd	99	32	MAPK	MAPK	NNP
cord-264489-h1n9ywbd	99	33	dependent	dependent	JJ
cord-264489-h1n9ywbd	99	34	pathways	pathway	NNS
cord-264489-h1n9ywbd	99	35	.	.	.
cord-264489-h1n9ywbd	100	1	Binding	bind	VBG
cord-264489-h1n9ywbd	100	2	of	of	IN
cord-264489-h1n9ywbd	100	3	IL-18BP	IL-18BP	NNP
cord-264489-h1n9ywbd	100	4	to	to	IN
cord-264489-h1n9ywbd	100	5	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	100	6	leads	lead	VBZ
cord-264489-h1n9ywbd	100	7	to	to	IN
cord-264489-h1n9ywbd	100	8	neutralization	neutralization	NN
cord-264489-h1n9ywbd	100	9	,	,	,
cord-264489-h1n9ywbd	100	10	and	and	CC
cord-264489-h1n9ywbd	100	11	the	the	DT
cord-264489-h1n9ywbd	100	12	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	100	13	/	/	SYM
cord-264489-h1n9ywbd	100	14	IL-18R	IL-18R	NNP
cord-264489-h1n9ywbd	100	15	signaling	signal	VBG
cord-264489-h1n9ywbd	100	16	cascades	cascade	NNS
cord-264489-h1n9ywbd	100	17	are	be	VBP
cord-264489-h1n9ywbd	100	18	no	no	RB
cord-264489-h1n9ywbd	100	19	longer	long	RBR
cord-264489-h1n9ywbd	100	20	induced	induce	VBN
cord-264489-h1n9ywbd	100	21	(	(	-LRB-
cord-264489-h1n9ywbd	100	22	Kimura	Kimura	NNP
cord-264489-h1n9ywbd	100	23	et	et	FW
cord-264489-h1n9ywbd	100	24	al	al	NNP
cord-264489-h1n9ywbd	100	25	.	.	NNP
cord-264489-h1n9ywbd	100	26	2008	2008	CD
cord-264489-h1n9ywbd	100	27	;	;	.
cord-264489-h1n9ywbd	101	1	Krumm	Krumm	NNP
cord-264489-h1n9ywbd	101	2	et	et	FW
cord-264489-h1n9ywbd	101	3	al	al	NNP
cord-264489-h1n9ywbd	101	4	.	.	.
cord-264489-h1n9ywbd	102	1	2008	2008	CD
cord-264489-h1n9ywbd	102	2	;	;	:
cord-264489-h1n9ywbd	102	3	Dinarello	Dinarello	NNP
cord-264489-h1n9ywbd	102	4	et	et	NNP
cord-264489-h1n9ywbd	102	5	al	al	NNP
cord-264489-h1n9ywbd	102	6	.	.	NNP
cord-264489-h1n9ywbd	102	7	2013	2013	CD
cord-264489-h1n9ywbd	102	8	)	)	-RRB-
cord-264489-h1n9ywbd	102	9	.	.	.
cord-264489-h1n9ywbd	103	1	The	the	DT
cord-264489-h1n9ywbd	103	2	biological	biological	JJ
cord-264489-h1n9ywbd	103	3	sequence	sequence	NN
cord-264489-h1n9ywbd	103	4	alignment	alignment	NN
cord-264489-h1n9ywbd	103	5	between	between	IN
cord-264489-h1n9ywbd	104	1	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	104	2	/	/	SYM
cord-264489-h1n9ywbd	104	3	IL-1	IL-1	NNP
cord-264489-h1n9ywbd	104	4	and	and	CC
cord-264489-h1n9ywbd	104	5	IL-18R1	il-18r1	CD
cord-264489-h1n9ywbd	104	6	/	/	SYM
cord-264489-h1n9ywbd	104	7	IL-1R	il-1r	CD
cord-264489-h1n9ywbd	104	8	type	type	NN
cord-264489-h1n9ywbd	104	9	1	1	CD
cord-264489-h1n9ywbd	104	10	and	and	CC
cord-264489-h1n9ywbd	104	11	2	2	CD
cord-264489-h1n9ywbd	104	12	are	be	VBP
cord-264489-h1n9ywbd	105	1	(	(	-LRB-
cord-264489-h1n9ywbd	105	2	Kato	Kato	NNP
cord-264489-h1n9ywbd	105	3	et	et	NNP
cord-264489-h1n9ywbd	105	4	al	al	NNP
cord-264489-h1n9ywbd	105	5	.	.	.
cord-264489-h1n9ywbd	106	1	2003	2003	CD
cord-264489-h1n9ywbd	106	2	;	;	:
cord-264489-h1n9ywbd	106	3	Yamamoto	Yamamoto	NNP
cord-264489-h1n9ywbd	106	4	et	et	NNP
cord-264489-h1n9ywbd	106	5	al	al	NNP
cord-264489-h1n9ywbd	106	6	.	.	.
cord-264489-h1n9ywbd	107	1	2004	2004	CD
cord-264489-h1n9ywbd	107	2	;	;	:
cord-264489-h1n9ywbd	107	3	Tsutsumi	Tsutsumi	NNP
cord-264489-h1n9ywbd	107	4	et	et	NNP
cord-264489-h1n9ywbd	107	5	al	al	NNP
cord-264489-h1n9ywbd	107	6	.	.	NNP
cord-264489-h1n9ywbd	107	7	2014	2014	CD
cord-264489-h1n9ywbd	107	8	)	)	-RRB-
cord-264489-h1n9ywbd	107	9	.	.	.
cord-264489-h1n9ywbd	108	1	The	the	DT
cord-264489-h1n9ywbd	108	2	alignment	alignment	NN
cord-264489-h1n9ywbd	108	3	schemes	scheme	NNS
cord-264489-h1n9ywbd	108	4	presented	present	VBN
cord-264489-h1n9ywbd	108	5	here	here	RB
cord-264489-h1n9ywbd	108	6	(	(	-LRB-
cord-264489-h1n9ywbd	108	7	Figs	fig	NNS
cord-264489-h1n9ywbd	108	8	.	.	.
cord-264489-h1n9ywbd	109	1	S1	S1	NNP
cord-264489-h1n9ywbd	109	2	and	and	CC
cord-264489-h1n9ywbd	109	3	S2	S2	NNP
cord-264489-h1n9ywbd	109	4	)	)	-RRB-
cord-264489-h1n9ywbd	109	5	follow	follow	VBP
cord-264489-h1n9ywbd	109	6	the	the	DT
cord-264489-h1n9ywbd	109	7	format	format	NN
cord-264489-h1n9ywbd	109	8	used	use	VBN
cord-264489-h1n9ywbd	109	9	by	by	IN
cord-264489-h1n9ywbd	109	10	them	-PRON-	PRP
cord-264489-h1n9ywbd	109	11	.	.	.
cord-264489-h1n9ywbd	110	1	These	these	DT
cord-264489-h1n9ywbd	110	2	multiple	multiple	JJ
cord-264489-h1n9ywbd	110	3	sequence	sequence	NN
cord-264489-h1n9ywbd	110	4	alignments	alignment	NNS
cord-264489-h1n9ywbd	110	5	are	be	VBP
cord-264489-h1n9ywbd	110	6	generated	generate	VBN
cord-264489-h1n9ywbd	110	7	using	use	VBG
cord-264489-h1n9ywbd	110	8	the	the	DT
cord-264489-h1n9ywbd	110	9	clustal	clustal	NNP
cord-264489-h1n9ywbd	110	10	omega	omega	NN
cord-264489-h1n9ywbd	110	11	(	(	-LRB-
cord-264489-h1n9ywbd	110	12	clustalW	clustalW	NNP
cord-264489-h1n9ywbd	110	13	)	)	-RRB-
cord-264489-h1n9ywbd	110	14	algorithm	algorithm	NN
cord-264489-h1n9ywbd	110	15	(	(	-LRB-
cord-264489-h1n9ywbd	110	16	Sievers	Sievers	NNP
cord-264489-h1n9ywbd	110	17	et	et	NNP
cord-264489-h1n9ywbd	110	18	al	al	NNP
cord-264489-h1n9ywbd	110	19	.	.	NNP
cord-264489-h1n9ywbd	110	20	2011	2011	CD
cord-264489-h1n9ywbd	110	21	)	)	-RRB-
cord-264489-h1n9ywbd	110	22	of	of	IN
cord-264489-h1n9ywbd	110	23	MEGA	mega	JJ
cord-264489-h1n9ywbd	110	24	software	software	NN
cord-264489-h1n9ywbd	110	25	,	,	,
cord-264489-h1n9ywbd	110	26	(	(	-LRB-
cord-264489-h1n9ywbd	110	27	Kumar	Kumar	NNP
cord-264489-h1n9ywbd	110	28	et	et	NNP
cord-264489-h1n9ywbd	110	29	al	al	NNP
cord-264489-h1n9ywbd	110	30	.	.	.
cord-264489-h1n9ywbd	110	31	2016	2016	CD
cord-264489-h1n9ywbd	110	32	)	)	-RRB-
cord-264489-h1n9ywbd	110	33	along	along	IN
cord-264489-h1n9ywbd	110	34	with	with	IN
cord-264489-h1n9ywbd	110	35	the	the	DT
cord-264489-h1n9ywbd	110	36	incorporation	incorporation	NN
cord-264489-h1n9ywbd	110	37	of	of	IN
cord-264489-h1n9ywbd	110	38	the	the	DT
cord-264489-h1n9ywbd	110	39	Blocks	Blocks	NNP
cord-264489-h1n9ywbd	110	40	Substitution	Substitution	NNP
cord-264489-h1n9ywbd	110	41	Matrix	Matrix	NNP
cord-264489-h1n9ywbd	110	42	(	(	-LRB-
cord-264489-h1n9ywbd	110	43	BLOSUM	BLOSUM	NNP
cord-264489-h1n9ywbd	110	44	)	)	-RRB-
cord-264489-h1n9ywbd	111	1	(	(	-LRB-
cord-264489-h1n9ywbd	111	2	Henikoff	Henikoff	NNP
cord-264489-h1n9ywbd	111	3	and	and	CC
cord-264489-h1n9ywbd	111	4	Henikoff	Henikoff	NNP
cord-264489-h1n9ywbd	111	5	1992	1992	CD
cord-264489-h1n9ywbd	112	1	(	(	-LRB-
cord-264489-h1n9ywbd	112	2	Yamamoto	Yamamoto	NNP
cord-264489-h1n9ywbd	112	3	et	et	NNP
cord-264489-h1n9ywbd	112	4	al	al	NNP
cord-264489-h1n9ywbd	112	5	.	.	.
cord-264489-h1n9ywbd	112	6	2004	2004	CD
cord-264489-h1n9ywbd	112	7	)	)	-RRB-
cord-264489-h1n9ywbd	112	8	.	.	.
cord-264489-h1n9ywbd	113	1	In	in	IN
cord-264489-h1n9ywbd	113	2	IL-1	IL-1	NNP
cord-264489-h1n9ywbd	113	3	the	the	DT
cord-264489-h1n9ywbd	113	4	S	s	NN
cord-264489-h1n9ywbd	113	5	-	-	HYPH
cord-264489-h1n9ywbd	113	6	glutathionylation	glutathionylation	NN
cord-264489-h1n9ywbd	113	7	of	of	IN
cord-264489-h1n9ywbd	113	8	a	a	DT
cord-264489-h1n9ywbd	113	9	highly	highly	RB
cord-264489-h1n9ywbd	113	10	conserved	conserve	VBN
cord-264489-h1n9ywbd	113	11	Cys	Cys	NNP
cord-264489-h1n9ywbd	113	12	residue	residue	NN
cord-264489-h1n9ywbd	113	13	is	be	VBZ
cord-264489-h1n9ywbd	113	14	considered	consider	VBN
cord-264489-h1n9ywbd	113	15	as	as	IN
cord-264489-h1n9ywbd	113	16	a	a	DT
cord-264489-h1n9ywbd	113	17	therapeutic	therapeutic	JJ
cord-264489-h1n9ywbd	113	18	target	target	NN
cord-264489-h1n9ywbd	113	19	(	(	-LRB-
cord-264489-h1n9ywbd	113	20	Zhang	Zhang	NNP
cord-264489-h1n9ywbd	113	21	et	et	NNP
cord-264489-h1n9ywbd	113	22	al	al	NNP
cord-264489-h1n9ywbd	113	23	.	.	.
cord-264489-h1n9ywbd	113	24	2017	2017	CD
cord-264489-h1n9ywbd	113	25	)	)	-RRB-
cord-264489-h1n9ywbd	113	26	.	.	.
cord-264489-h1n9ywbd	114	1	At	at	IN
cord-264489-h1n9ywbd	114	2	this	this	DT
cord-264489-h1n9ywbd	114	3	time	time	NN
cord-264489-h1n9ywbd	114	4	,	,	,
cord-264489-h1n9ywbd	114	5	the	the	DT
cord-264489-h1n9ywbd	114	6	possibility	possibility	NN
cord-264489-h1n9ywbd	114	7	of	of	IN
cord-264489-h1n9ywbd	114	8	utilizing	utilize	VBG
cord-264489-h1n9ywbd	114	9	the	the	DT
cord-264489-h1n9ywbd	114	10	conserved	conserve	VBN
cord-264489-h1n9ywbd	114	11	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	114	12	or	or	CC
cord-264489-h1n9ywbd	114	13	IL-18R	IL-18R	NNP
cord-264489-h1n9ywbd	114	14	Cys	Cys	NNP
cord-264489-h1n9ywbd	114	15	residues	residue	NNS
cord-264489-h1n9ywbd	114	16	as	as	IN
cord-264489-h1n9ywbd	114	17	potential	potential	JJ
cord-264489-h1n9ywbd	114	18	drug	drug	NN
cord-264489-h1n9ywbd	114	19	targets	target	NNS
cord-264489-h1n9ywbd	114	20	for	for	IN
cord-264489-h1n9ywbd	114	21	various	various	JJ
cord-264489-h1n9ywbd	114	22	infectious	infectious	JJ
cord-264489-h1n9ywbd	114	23	or	or	CC
cord-264489-h1n9ywbd	114	24	chronic	chronic	JJ
cord-264489-h1n9ywbd	114	25	diseases	disease	NNS
cord-264489-h1n9ywbd	114	26	remains	remain	VBZ
cord-264489-h1n9ywbd	114	27	a	a	DT
cord-264489-h1n9ywbd	114	28	subject	subject	NN
cord-264489-h1n9ywbd	114	29	of	of	IN
cord-264489-h1n9ywbd	114	30	future	future	JJ
cord-264489-h1n9ywbd	114	31	investigations	investigation	NNS
cord-264489-h1n9ywbd	114	32	.	.	.
cord-264489-h1n9ywbd	115	1	ligand	ligand	NN
cord-264489-h1n9ywbd	115	2	-	-	HYPH
cord-264489-h1n9ywbd	115	3	protein	protein	NN
cord-264489-h1n9ywbd	115	4	(	(	-LRB-
cord-264489-h1n9ywbd	115	5	Kato	Kato	NNP
cord-264489-h1n9ywbd	115	6	et	et	NNP
cord-264489-h1n9ywbd	115	7	al	al	NNP
cord-264489-h1n9ywbd	115	8	.	.	NNP
cord-264489-h1n9ywbd	115	9	2003	2003	CD
cord-264489-h1n9ywbd	115	10	)	)	-RRB-
cord-264489-h1n9ywbd	115	11	.	.	.
cord-264489-h1n9ywbd	116	1	This	this	DT
cord-264489-h1n9ywbd	116	2	is	be	VBZ
cord-264489-h1n9ywbd	116	3	a	a	DT
cord-264489-h1n9ywbd	116	4	single	single	JJ
cord-264489-h1n9ywbd	116	5	subunit	subunit	NN
cord-264489-h1n9ywbd	116	6	protein	protein	NN
cord-264489-h1n9ywbd	116	7	that	that	WDT
cord-264489-h1n9ywbd	116	8	mostly	mostly	RB
cord-264489-h1n9ywbd	116	9	contains	contain	VBZ
cord-264489-h1n9ywbd	116	10	sheets	sheets	CD
cord-264489-h1n9ywbd	116	11	.	.	.
cord-264489-h1n9ywbd	117	1	The	the	DT
cord-264489-h1n9ywbd	117	2	undefined	undefined	JJ
cord-264489-h1n9ywbd	117	3	loop	loop	NN
cord-264489-h1n9ywbd	117	4	structure	structure	NN
cord-264489-h1n9ywbd	117	5	in	in	IN
cord-264489-h1n9ywbd	117	6	1J0S	1j0s	CD
cord-264489-h1n9ywbd	117	7	consists	consist	NNS
cord-264489-h1n9ywbd	117	8	of	of	IN
cord-264489-h1n9ywbd	117	9	residues	residue	NNS
cord-264489-h1n9ywbd	117	10	34	34	CD
cord-264489-h1n9ywbd	117	11	-	-	SYM
cord-264489-h1n9ywbd	117	12	42	42	CD
cord-264489-h1n9ywbd	117	13	.	.	.
cord-264489-h1n9ywbd	118	1	Fig	Fig	NNP
cord-264489-h1n9ywbd	118	2	.	.	.
cord-264489-h1n9ywbd	118	3	4A	4a	CD
cord-264489-h1n9ywbd	118	4	(	(	-LRB-
cord-264489-h1n9ywbd	118	5	Kato	Kato	NNP
cord-264489-h1n9ywbd	118	6	et	et	NNP
cord-264489-h1n9ywbd	118	7	al	al	NNP
cord-264489-h1n9ywbd	118	8	.	.	NNP
cord-264489-h1n9ywbd	118	9	2003	2003	CD
cord-264489-h1n9ywbd	118	10	)	)	-RRB-
cord-264489-h1n9ywbd	118	11	.	.	.
cord-264489-h1n9ywbd	119	1	These	these	DT
cord-264489-h1n9ywbd	119	2	residues	residue	NNS
cord-264489-h1n9ywbd	119	3	have	have	VBP
cord-264489-h1n9ywbd	119	4	been	be	VBN
cord-264489-h1n9ywbd	119	5	highlighted	highlight	VBN
cord-264489-h1n9ywbd	119	6	in	in	IN
cord-264489-h1n9ywbd	119	7	a	a	DT
cord-264489-h1n9ywbd	119	8	"	"	``
cord-264489-h1n9ywbd	119	9	green	green	JJ
cord-264489-h1n9ywbd	119	10	stick	stick	NN
cord-264489-h1n9ywbd	119	11	"	"	''
cord-264489-h1n9ywbd	119	12	mode	mode	NN
cord-264489-h1n9ywbd	119	13	within	within	IN
cord-264489-h1n9ywbd	119	14	the	the	DT
cord-264489-h1n9ywbd	119	15	primary	primary	JJ
cord-264489-h1n9ywbd	119	16	interactions	interaction	NNS
cord-264489-h1n9ywbd	119	17	site	site	NN
cord-264489-h1n9ywbd	119	18	of	of	IN
cord-264489-h1n9ywbd	119	19	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	119	20	and	and	CC
cord-264489-h1n9ywbd	119	21	the	the	DT
cord-264489-h1n9ywbd	119	22	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	119	23	bound	bind	VBN
cord-264489-h1n9ywbd	119	24	receptor	receptor	NN
cord-264489-h1n9ywbd	119	25	structures	structure	NNS
cord-264489-h1n9ywbd	119	26	.	.	.
cord-264489-h1n9ywbd	120	1	3WO2	3wo2	LS
cord-264489-h1n9ywbd	120	2	is	be	VBZ
cord-264489-h1n9ywbd	120	3	the	the	DT
cord-264489-h1n9ywbd	120	4	X	X	NNP
cord-264489-h1n9ywbd	120	5	ray	ray	NN
cord-264489-h1n9ywbd	120	6	crystal	crystal	NN
cord-264489-h1n9ywbd	120	7	structure	structure	NN
cord-264489-h1n9ywbd	120	8	of	of	IN
cord-264489-h1n9ywbd	120	9	wildtype	wildtype	NN
cord-264489-h1n9ywbd	120	10	(	(	-LRB-
cord-264489-h1n9ywbd	120	11	wt	wt	NN
cord-264489-h1n9ywbd	120	12	)	)	-RRB-
cord-264489-h1n9ywbd	120	13	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	120	14	ligand	ligand	NN
cord-264489-h1n9ywbd	120	15	-	-	HYPH
cord-264489-h1n9ywbd	120	16	protein	protein	NN
cord-264489-h1n9ywbd	120	17	(	(	-LRB-
cord-264489-h1n9ywbd	120	18	Tsutsumi	Tsutsumi	NNP
cord-264489-h1n9ywbd	120	19	et	et	FW
cord-264489-h1n9ywbd	120	20	al	al	NNP
cord-264489-h1n9ywbd	120	21	.	.	.
cord-264489-h1n9ywbd	121	1	2014	2014	CD
cord-264489-h1n9ywbd	121	2	SD	SD	NNP
cord-264489-h1n9ywbd	121	3	Table	Table	NNP
cord-264489-h1n9ywbd	121	4	S3	s3	NN
cord-264489-h1n9ywbd	121	5	.	.	.
cord-264489-h1n9ywbd	122	1	The	the	DT
cord-264489-h1n9ywbd	122	2	X	x	NN
cord-264489-h1n9ywbd	122	3	ray	ray	NN
cord-264489-h1n9ywbd	122	4	crystal	crystal	NN
cord-264489-h1n9ywbd	122	5	structure	structure	NN
cord-264489-h1n9ywbd	122	6	of	of	IN
cord-264489-h1n9ywbd	122	7	the	the	DT
cord-264489-h1n9ywbd	122	8	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	122	9	signaling	signal	VBG
cord-264489-h1n9ywbd	122	10	complex	complex	NN
cord-264489-h1n9ywbd	122	11	,	,	,
cord-264489-h1n9ywbd	122	12	3WO4	3wo4	CD
cord-264489-h1n9ywbd	122	13	,	,	,
cord-264489-h1n9ywbd	122	14	is	be	VBZ
cord-264489-h1n9ywbd	122	15	displayed	display	VBN
cord-264489-h1n9ywbd	122	16	in	in	IN
cord-264489-h1n9ywbd	122	17	Fig	Fig	NNP
cord-264489-h1n9ywbd	122	18	.	.	.
cord-264489-h1n9ywbd	123	1	4D	4d	LS
cord-264489-h1n9ywbd	123	2	(	(	-LRB-
cord-264489-h1n9ywbd	123	3	Tsutsumi	Tsutsumi	NNP
cord-264489-h1n9ywbd	123	4	et	et	NNP
cord-264489-h1n9ywbd	123	5	al	al	NNP
cord-264489-h1n9ywbd	123	6	.	.	NNP
cord-264489-h1n9ywbd	123	7	2014	2014	CD
cord-264489-h1n9ywbd	123	8	)	)	-RRB-
cord-264489-h1n9ywbd	123	9	.	.	.
cord-264489-h1n9ywbd	124	1	This	this	DT
cord-264489-h1n9ywbd	124	2	core	core	NN
cord-264489-h1n9ywbd	124	3	signaling	signal	VBG
cord-264489-h1n9ywbd	124	4	complex	complex	NN
cord-264489-h1n9ywbd	124	5	consists	consist	VBZ
cord-264489-h1n9ywbd	124	6	of	of	IN
cord-264489-h1n9ywbd	124	7	a	a	DT
cord-264489-h1n9ywbd	124	8	ternary	ternary	JJ
cord-264489-h1n9ywbd	124	9	structure	structure	NN
cord-264489-h1n9ywbd	124	10	of	of	IN
cord-264489-h1n9ywbd	124	11	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	124	12	4D	4d	CD
cord-264489-h1n9ywbd	124	13	.	.	.
cord-264489-h1n9ywbd	125	1	These	these	DT
cord-264489-h1n9ywbd	125	2	primary	primary	JJ
cord-264489-h1n9ywbd	125	3	site	site	NN
cord-264489-h1n9ywbd	125	4	III	iii	CD
cord-264489-h1n9ywbd	125	5	residues	residue	NNS
cord-264489-h1n9ywbd	125	6	have	have	VBP
cord-264489-h1n9ywbd	125	7	also	also	RB
cord-264489-h1n9ywbd	125	8	been	be	VBN
cord-264489-h1n9ywbd	125	9	highlighted	highlight	VBN
cord-264489-h1n9ywbd	125	10	accordingly	accordingly	RB
cord-264489-h1n9ywbd	125	11	in	in	IN
cord-264489-h1n9ywbd	125	12	SD	SD	NNP
cord-264489-h1n9ywbd	125	13	Table	Table	NNP
cord-264489-h1n9ywbd	125	14	S4	S4	NNP
cord-264489-h1n9ywbd	125	15	.	.	.
cord-264489-h1n9ywbd	126	1	3F62	3F62	NNP
cord-264489-h1n9ywbd	126	2	,	,	,
cord-264489-h1n9ywbd	126	3	an	an	DT
cord-264489-h1n9ywbd	126	4	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	126	5	complex	complex	JJ
cord-264489-h1n9ywbd	126	6	with	with	IN
cord-264489-h1n9ywbd	126	7	the	the	DT
cord-264489-h1n9ywbd	126	8	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	126	9	binding	bind	VBG
cord-264489-h1n9ywbd	126	10	protein	protein	NN
cord-264489-h1n9ywbd	126	11	(	(	-LRB-
cord-264489-h1n9ywbd	126	12	IL-18BP	IL-18BP	NNP
cord-264489-h1n9ywbd	126	13	)	)	-RRB-
cord-264489-h1n9ywbd	126	14	of	of	IN
cord-264489-h1n9ywbd	126	15	Ectromelia	Ectromelia	NNP
cord-264489-h1n9ywbd	126	16	virus	virus	NN
cord-264489-h1n9ywbd	126	17	is	be	VBZ
cord-264489-h1n9ywbd	126	18	displayed	display	VBN
cord-264489-h1n9ywbd	126	19	in	in	IN
cord-264489-h1n9ywbd	126	20	Fig	Fig	NNP
cord-264489-h1n9ywbd	126	21	.	.	.
cord-264489-h1n9ywbd	126	22	4F	4F	NNP
cord-264489-h1n9ywbd	126	23	.	.	.
cord-264489-h1n9ywbd	127	1	This	this	DT
cord-264489-h1n9ywbd	127	2	structure	structure	NN
cord-264489-h1n9ywbd	127	3	of	of	IN
cord-264489-h1n9ywbd	127	4	3F62	3F62	NNP
cord-264489-h1n9ywbd	127	5	has	have	VBZ
cord-264489-h1n9ywbd	127	6	been	be	VBN
cord-264489-h1n9ywbd	127	7	described	describe	VBN
cord-264489-h1n9ywbd	127	8	by	by	IN
cord-264489-h1n9ywbd	127	9	Krumm	Krumm	NNP
cord-264489-h1n9ywbd	127	10	et	et	NNP
cord-264489-h1n9ywbd	127	11	al	al	NNP
cord-264489-h1n9ywbd	127	12	.	.	.
cord-264489-h1n9ywbd	128	1	(	(	-LRB-
cord-264489-h1n9ywbd	128	2	Krumm	Krumm	NNP
cord-264489-h1n9ywbd	128	3	et	et	FW
cord-264489-h1n9ywbd	128	4	al	al	NNP
cord-264489-h1n9ywbd	128	5	.	.	NNP
cord-264489-h1n9ywbd	128	6	2008	2008	CD
cord-264489-h1n9ywbd	128	7	)	)	-RRB-
cord-264489-h1n9ywbd	128	8	.	.	.
cord-264489-h1n9ywbd	129	1	Part	part	NN
cord-264489-h1n9ywbd	129	2	of	of	IN
cord-264489-h1n9ywbd	129	3	the	the	DT
cord-264489-h1n9ywbd	129	4	IL-18R	il-18r	NN
cord-264489-h1n9ywbd	129	5	resembles	resemble	VBZ
cord-264489-h1n9ywbd	129	6	IL-18BP	IL-18BP	NNP
cord-264489-h1n9ywbd	129	7	and	and	CC
cord-264489-h1n9ywbd	129	8	thus	thus	RB
cord-264489-h1n9ywbd	129	9	,	,	,
cord-264489-h1n9ywbd	129	10	the	the	DT
cord-264489-h1n9ywbd	129	11	binding	binding	NN
cord-264489-h1n9ywbd	129	12	of	of	IN
cord-264489-h1n9ywbd	129	13	IL-18BP	IL-18BP	NNP
cord-264489-h1n9ywbd	129	14	with	with	IN
cord-264489-h1n9ywbd	129	15	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	129	16	blocks	block	VBZ
cord-264489-h1n9ywbd	129	17	the	the	DT
cord-264489-h1n9ywbd	129	18	interactions	interaction	NNS
cord-264489-h1n9ywbd	129	19	between	between	IN
cord-264489-h1n9ywbd	129	20	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	129	21	and	and	CC
cord-264489-h1n9ywbd	129	22	IL-18R	IL-18R	NNP
cord-264489-h1n9ywbd	129	23	(	(	-LRB-
cord-264489-h1n9ywbd	129	24	Krumm	Krumm	NNP
cord-264489-h1n9ywbd	129	25	et	et	FW
cord-264489-h1n9ywbd	129	26	al	al	NNP
cord-264489-h1n9ywbd	129	27	.	.	.
cord-264489-h1n9ywbd	129	28	2008	2008	CD
cord-264489-h1n9ywbd	130	1	Buried	bury	VBN
cord-264489-h1n9ywbd	130	2	Cys	Cys	NNP
cord-264489-h1n9ywbd	130	3	residues	residue	NNS
cord-264489-h1n9ywbd	130	4	play	play	VBP
cord-264489-h1n9ywbd	130	5	a	a	DT
cord-264489-h1n9ywbd	130	6	leading	leading	JJ
cord-264489-h1n9ywbd	130	7	role	role	NN
cord-264489-h1n9ywbd	130	8	in	in	IN
cord-264489-h1n9ywbd	130	9	determining	determine	VBG
cord-264489-h1n9ywbd	130	10	the	the	DT
cord-264489-h1n9ywbd	130	11	protein	protein	NN
cord-264489-h1n9ywbd	130	12	's	's	POS
cord-264489-h1n9ywbd	130	13	structural	structural	JJ
cord-264489-h1n9ywbd	130	14	stability	stability	NN
cord-264489-h1n9ywbd	130	15	,	,	,
cord-264489-h1n9ywbd	130	16	since	since	IN
cord-264489-h1n9ywbd	130	17	buried	bury	VBN
cord-264489-h1n9ywbd	130	18	Cys	Cys	NNP
cord-264489-h1n9ywbd	130	19	residues	residue	NNS
cord-264489-h1n9ywbd	130	20	are	be	VBP
cord-264489-h1n9ywbd	130	21	usually	usually	RB
cord-264489-h1n9ywbd	130	22	embedded	embed	VBN
cord-264489-h1n9ywbd	130	23	within	within	IN
cord-264489-h1n9ywbd	130	24	a	a	DT
cord-264489-h1n9ywbd	130	25	protein	protein	NN
cord-264489-h1n9ywbd	130	26	's	's	POS
cord-264489-h1n9ywbd	130	27	hydrophobic	hydrophobic	JJ
cord-264489-h1n9ywbd	130	28	core	core	NN
cord-264489-h1n9ywbd	130	29	.	.	.
cord-264489-h1n9ywbd	131	1	Being	be	VBG
cord-264489-h1n9ywbd	131	2	surrounded	surround	VBN
cord-264489-h1n9ywbd	131	3	by	by	IN
cord-264489-h1n9ywbd	131	4	various	various	JJ
cord-264489-h1n9ywbd	131	5	hydrophobic	hydrophobic	JJ
cord-264489-h1n9ywbd	131	6	and	and	CC
cord-264489-h1n9ywbd	131	7	aromatic	aromatic	JJ
cord-264489-h1n9ywbd	131	8	residues	residue	NNS
cord-264489-h1n9ywbd	131	9	they	-PRON-	PRP
cord-264489-h1n9ywbd	131	10	form	form	VBP
cord-264489-h1n9ywbd	131	11	hydrophobic	hydrophobic	JJ
cord-264489-h1n9ywbd	131	12	and	and	CC
cord-264489-h1n9ywbd	131	13	other	other	JJ
cord-264489-h1n9ywbd	131	14	nonbonded	nonbonded	JJ
cord-264489-h1n9ywbd	131	15	interactions	interaction	NNS
cord-264489-h1n9ywbd	131	16	and	and	CC
cord-264489-h1n9ywbd	131	17	thus	thus	RB
cord-264489-h1n9ywbd	131	18	make	make	VB
cord-264489-h1n9ywbd	131	19	the	the	DT
cord-264489-h1n9ywbd	131	20	protein	protein	NN
cord-264489-h1n9ywbd	131	21	structure	structure	NN
cord-264489-h1n9ywbd	131	22	more	more	RBR
cord-264489-h1n9ywbd	131	23	compact	compact	JJ
cord-264489-h1n9ywbd	131	24	and	and	CC
cord-264489-h1n9ywbd	131	25	stable	stable	JJ
cord-264489-h1n9ywbd	131	26	.	.	.
cord-264489-h1n9ywbd	132	1	In	in	IN
cord-264489-h1n9ywbd	132	2	3WO3/3WO4	3wo3/3wo4	CD
cord-264489-h1n9ywbd	132	3	,	,	,
cord-264489-h1n9ywbd	132	4	most	most	JJS
cord-264489-h1n9ywbd	132	5	of	of	IN
cord-264489-h1n9ywbd	132	6	the	the	DT
cord-264489-h1n9ywbd	132	7	Cys	Cys	NNP
cord-264489-h1n9ywbd	132	8	residues	residue	NNS
cord-264489-h1n9ywbd	132	9	and	and	CC
cord-264489-h1n9ywbd	132	10	disulfide	disulfide	NN
cord-264489-h1n9ywbd	132	11	bridges	bridge	NNS
cord-264489-h1n9ywbd	132	12	of	of	IN
cord-264489-h1n9ywbd	132	13	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	132	14	and	and	CC
cord-264489-h1n9ywbd	132	15	IL-18R	il-18r	XX
cord-264489-h1n9ywbd	132	16	receptor	receptor	NN
cord-264489-h1n9ywbd	132	17	chains	chain	NNS
cord-264489-h1n9ywbd	132	18	are	be	VBP
cord-264489-h1n9ywbd	132	19	buried	bury	VBN
cord-264489-h1n9ywbd	132	20	,	,	,
cord-264489-h1n9ywbd	132	21	and	and	CC
cord-264489-h1n9ywbd	132	22	hence	hence	RB
cord-264489-h1n9ywbd	132	23	,	,	,
cord-264489-h1n9ywbd	132	24	are	be	VBP
cord-264489-h1n9ywbd	132	25	subject	subject	JJ
cord-264489-h1n9ywbd	132	26	to	to	IN
cord-264489-h1n9ywbd	132	27	the	the	DT
cord-264489-h1n9ywbd	132	28	aforesaid	aforesaid	JJ
cord-264489-h1n9ywbd	132	29	stability	stability	NN
cord-264489-h1n9ywbd	132	30	criterion	criterion	NN
cord-264489-h1n9ywbd	132	31	.	.	.
cord-264489-h1n9ywbd	133	1	In	in	IN
cord-264489-h1n9ywbd	133	2	the	the	DT
cord-264489-h1n9ywbd	133	3	3WO4	3wo4	CD
cord-264489-h1n9ywbd	133	4	:	:	:
cord-264489-h1n9ywbd	133	5	IL-18Rsubunit	IL-18Rsubunit	NNP
cord-264489-h1n9ywbd	133	6	,	,	,
cord-264489-h1n9ywbd	133	7	however	however	RB
cord-264489-h1n9ywbd	133	8	,	,	,
cord-264489-h1n9ywbd	133	9	the	the	DT
cord-264489-h1n9ywbd	133	10	Cys	Cys	NNP
cord-264489-h1n9ywbd	133	11	residues	residue	NNS
cord-264489-h1n9ywbd	133	12	and	and	CC
cord-264489-h1n9ywbd	133	13	some	some	DT
cord-264489-h1n9ywbd	133	14	of	of	IN
cord-264489-h1n9ywbd	133	15	the	the	DT
cord-264489-h1n9ywbd	133	16	disulfide	disulfide	NN
cord-264489-h1n9ywbd	133	17	bridges	bridge	NNS
cord-264489-h1n9ywbd	133	18	are	are	VBG
cord-264489-h1n9ywbd	133	19	mostly	mostly	RB
cord-264489-h1n9ywbd	133	20	surfaceexposed	surfaceexposed	JJ
cord-264489-h1n9ywbd	133	21	.	.	.
cord-264489-h1n9ywbd	134	1	In	in	IN
cord-264489-h1n9ywbd	134	2	our	-PRON-	PRP$
cord-264489-h1n9ywbd	134	3	previous	previous	JJ
cord-264489-h1n9ywbd	134	4	paper	paper	NN
cord-264489-h1n9ywbd	134	5	,	,	,
cord-264489-h1n9ywbd	134	6	we	-PRON-	PRP
cord-264489-h1n9ywbd	134	7	have	have	VBP
cord-264489-h1n9ywbd	134	8	addressed	address	VBN
cord-264489-h1n9ywbd	134	9	the	the	DT
cord-264489-h1n9ywbd	134	10	Cys	Cys	NNP
cord-264489-h1n9ywbd	134	11	residue	residue	NN
cord-264489-h1n9ywbd	134	12	stability	stability	NN
cord-264489-h1n9ywbd	134	13	resulting	result	VBG
cord-264489-h1n9ywbd	134	14	from	from	IN
cord-264489-h1n9ywbd	134	15	metal	metal	NN
cord-264489-h1n9ywbd	134	16	binding	binding	NN
cord-264489-h1n9ywbd	134	17	or	or	CC
cord-264489-h1n9ywbd	134	18	structural	structural	JJ
cord-264489-h1n9ywbd	134	19	effects	effect	NNS
cord-264489-h1n9ywbd	134	20	(	(	-LRB-
cord-264489-h1n9ywbd	134	21	Roy	Roy	NNP
cord-264489-h1n9ywbd	134	22	and	and	CC
cord-264489-h1n9ywbd	134	23	Luck	Luck	NNP
cord-264489-h1n9ywbd	134	24	2011	2011	CD
cord-264489-h1n9ywbd	134	25	)	)	-RRB-
cord-264489-h1n9ywbd	134	26	.	.	.
cord-264489-h1n9ywbd	135	1	Here	here	RB
cord-264489-h1n9ywbd	135	2	,	,	,
cord-264489-h1n9ywbd	135	3	our	-PRON-	PRP$
cord-264489-h1n9ywbd	135	4	goal	goal	NN
cord-264489-h1n9ywbd	135	5	is	be	VBZ
cord-264489-h1n9ywbd	135	6	to	to	TO
cord-264489-h1n9ywbd	135	7	examine	examine	VB
cord-264489-h1n9ywbd	135	8	how	how	WRB
cord-264489-h1n9ywbd	135	9	disulfide	disulfide	JJ
cord-264489-h1n9ywbd	135	10	connectivity	connectivity	NN
cord-264489-h1n9ywbd	135	11	increases	increase	VBZ
cord-264489-h1n9ywbd	135	12	the	the	DT
cord-264489-h1n9ywbd	135	13	overall	overall	JJ
cord-264489-h1n9ywbd	135	14	stability	stability	NN
cord-264489-h1n9ywbd	135	15	in	in	IN
cord-264489-h1n9ywbd	135	16	a	a	DT
cord-264489-h1n9ywbd	135	17	protein	protein	NN
cord-264489-h1n9ywbd	135	18	complex	complex	NN
cord-264489-h1n9ywbd	135	19	.	.	.
cord-264489-h1n9ywbd	136	1	Previous	previous	JJ
cord-264489-h1n9ywbd	136	2	authors	author	NNS
cord-264489-h1n9ywbd	136	3	explored	explore	VBD
cord-264489-h1n9ywbd	136	4	the	the	DT
cord-264489-h1n9ywbd	136	5	possibility	possibility	NN
cord-264489-h1n9ywbd	136	6	of	of	IN
cord-264489-h1n9ywbd	136	7	mutating	mutate	VBG
cord-264489-h1n9ywbd	136	8	Cys	Cys	NNP
cord-264489-h1n9ywbd	136	9	(	(	-LRB-
cord-264489-h1n9ywbd	136	10	SH	SH	NNP
cord-264489-h1n9ywbd	136	11	)	)	-RRB-
cord-264489-h1n9ywbd	136	12	to	to	TO
cord-264489-h1n9ywbd	136	13	increase	increase	VB
cord-264489-h1n9ywbd	136	14	the	the	DT
cord-264489-h1n9ywbd	136	15	overall	overall	JJ
cord-264489-h1n9ywbd	136	16	stability	stability	NN
cord-264489-h1n9ywbd	136	17	of	of	IN
cord-264489-h1n9ywbd	136	18	a	a	DT
cord-264489-h1n9ywbd	136	19	protein	protein	NN
cord-264489-h1n9ywbd	136	20	(	(	-LRB-
cord-264489-h1n9ywbd	136	21	Yamamoto	Yamamoto	NNP
cord-264489-h1n9ywbd	136	22	et	et	NNP
cord-264489-h1n9ywbd	136	23	al	al	NNP
cord-264489-h1n9ywbd	136	24	.	.	.
cord-264489-h1n9ywbd	136	25	2004	2004	CD
cord-264489-h1n9ywbd	136	26	)	)	-RRB-
cord-264489-h1n9ywbd	136	27	.	.	.
cord-264489-h1n9ywbd	137	1	To	to	TO
cord-264489-h1n9ywbd	137	2	check	check	VB
cord-264489-h1n9ywbd	137	3	the	the	DT
cord-264489-h1n9ywbd	137	4	overall	overall	JJ
cord-264489-h1n9ywbd	137	5	efficacy	efficacy	NN
cord-264489-h1n9ywbd	137	6	of	of	IN
cord-264489-h1n9ywbd	137	7	the	the	DT
cord-264489-h1n9ywbd	137	8	3D	3d	JJ
cord-264489-h1n9ywbd	137	9	models	model	NNS
cord-264489-h1n9ywbd	137	10	,	,	,
cord-264489-h1n9ywbd	137	11	the	the	DT
cord-264489-h1n9ywbd	137	12	initial	initial	JJ
cord-264489-h1n9ywbd	137	13	protein	protein	NN
cord-264489-h1n9ywbd	137	14	structures	structure	NNS
cord-264489-h1n9ywbd	137	15	were	be	VBD
cord-264489-h1n9ywbd	137	16	assessed	assess	VBN
cord-264489-h1n9ywbd	137	17	.	.	.
cord-264489-h1n9ywbd	138	1	Ramachandran	Ramachandran	NNP
cord-264489-h1n9ywbd	138	2	plots	plot	NNS
cord-264489-h1n9ywbd	138	3	for	for	IN
cord-264489-h1n9ywbd	138	4	the	the	DT
cord-264489-h1n9ywbd	138	5	initial	initial	JJ
cord-264489-h1n9ywbd	138	6	structures	structure	NNS
cord-264489-h1n9ywbd	138	7	used	use	VBN
cord-264489-h1n9ywbd	138	8	in	in	IN
cord-264489-h1n9ywbd	138	9	MD	MD	NNP
cord-264489-h1n9ywbd	138	10	simulation	simulation	NN
cord-264489-h1n9ywbd	138	11	are	be	VBP
cord-264489-h1n9ywbd	138	12	depicted	depict	VBN
cord-264489-h1n9ywbd	138	13	in	in	IN
cord-264489-h1n9ywbd	138	14	SD	SD	NNP
cord-264489-h1n9ywbd	138	15	Fig	Fig	NNP
cord-264489-h1n9ywbd	138	16	S3	S3	NNP
cord-264489-h1n9ywbd	138	17	.	.	.
cord-264489-h1n9ywbd	139	1	These	these	DT
cord-264489-h1n9ywbd	139	2	plots	plot	NNS
cord-264489-h1n9ywbd	139	3	illustrate	illustrate	VBP
cord-264489-h1n9ywbd	139	4	the	the	DT
cord-264489-h1n9ywbd	139	5	favored	favor	VBN
cord-264489-h1n9ywbd	139	6	,	,	,
cord-264489-h1n9ywbd	139	7	allowed	allow	VBN
cord-264489-h1n9ywbd	139	8	and	and	CC
cord-264489-h1n9ywbd	139	9	disfavored	disfavor	VBN
cord-264489-h1n9ywbd	139	10	distributions	distribution	NNS
cord-264489-h1n9ywbd	139	11	of	of	IN
cord-264489-h1n9ywbd	139	12	phi	phi	NNP
cord-264489-h1n9ywbd	139	13	(	(	-LRB-
cord-264489-h1n9ywbd	139	14	φ)/psi	φ)/psi	NNP
cord-264489-h1n9ywbd	139	15	(	(	-LRB-
cord-264489-h1n9ywbd	139	16	ψ	ψ	LS
cord-264489-h1n9ywbd	139	17	)	)	-RRB-
cord-264489-h1n9ywbd	139	18	dihedral	dihedral	JJ
cord-264489-h1n9ywbd	139	19	angles	angle	NNS
cord-264489-h1n9ywbd	139	20	.	.	.
cord-264489-h1n9ywbd	140	1	The	the	DT
cord-264489-h1n9ywbd	140	2	structural	structural	JJ
cord-264489-h1n9ywbd	140	3	evaluations	evaluation	NNS
cord-264489-h1n9ywbd	140	4	of	of	IN
cord-264489-h1n9ywbd	140	5	these	these	DT
cord-264489-h1n9ywbd	140	6	figures	figure	NNS
cord-264489-h1n9ywbd	140	7	ensure	ensure	VBP
cord-264489-h1n9ywbd	140	8	that	that	IN
cord-264489-h1n9ywbd	140	9	most	most	JJS
cord-264489-h1n9ywbd	140	10	residues	residue	NNS
cord-264489-h1n9ywbd	140	11	are	be	VBP
cord-264489-h1n9ywbd	140	12	within	within	IN
cord-264489-h1n9ywbd	140	13	the	the	DT
cord-264489-h1n9ywbd	140	14	J	J	NNP
cord-264489-h1n9ywbd	140	15	o	o	NN
cord-264489-h1n9ywbd	140	16	u	u	NN
cord-264489-h1n9ywbd	140	17	r	r	NN
cord-264489-h1n9ywbd	140	18	n	n	NN
cord-264489-h1n9ywbd	140	19	a	a	DT
cord-264489-h1n9ywbd	140	20	l	l	NN
cord-264489-h1n9ywbd	140	21	P	p	NN
cord-264489-h1n9ywbd	140	22	r	r	NN
cord-264489-h1n9ywbd	140	23	e	e	NN
cord-264489-h1n9ywbd	140	24	-p	-p	NN
cord-264489-h1n9ywbd	141	1	r	r	NNP
cord-264489-h1n9ywbd	141	2	o	o	NN
cord-264489-h1n9ywbd	141	3	o	o	NN
cord-264489-h1n9ywbd	141	4	f	f	NN
cord-264489-h1n9ywbd	141	5	favored	favor	VBD
cord-264489-h1n9ywbd	141	6	and	and	CC
cord-264489-h1n9ywbd	141	7	allowed	allow	VBD
cord-264489-h1n9ywbd	141	8	region	region	NN
cord-264489-h1n9ywbd	141	9	(	(	-LRB-
cord-264489-h1n9ywbd	141	10	Lovell	Lovell	NNP
cord-264489-h1n9ywbd	141	11	et	et	NNP
cord-264489-h1n9ywbd	141	12	al	al	NNP
cord-264489-h1n9ywbd	141	13	.	.	NNP
cord-264489-h1n9ywbd	141	14	2003	2003	CD
cord-264489-h1n9ywbd	141	15	)	)	-RRB-
cord-264489-h1n9ywbd	141	16	.	.	.
cord-264489-h1n9ywbd	142	1	Overall	overall	RB
cord-264489-h1n9ywbd	142	2	,	,	,
cord-264489-h1n9ywbd	142	3	these	these	DT
cord-264489-h1n9ywbd	142	4	plots	plot	NNS
cord-264489-h1n9ywbd	142	5	indicate	indicate	VBP
cord-264489-h1n9ywbd	142	6	the	the	DT
cord-264489-h1n9ywbd	142	7	effectiveness	effectiveness	NN
cord-264489-h1n9ywbd	142	8	of	of	IN
cord-264489-h1n9ywbd	142	9	the	the	DT
cord-264489-h1n9ywbd	142	10	3D	3d	JJ
cord-264489-h1n9ywbd	142	11	structures	structure	NNS
cord-264489-h1n9ywbd	142	12	;	;	:
cord-264489-h1n9ywbd	142	13	further	further	JJ
cord-264489-h1n9ywbd	142	14	details	detail	NNS
cord-264489-h1n9ywbd	142	15	are	be	VBP
cord-264489-h1n9ywbd	142	16	explained	explain	VBN
cord-264489-h1n9ywbd	142	17	in	in	IN
cord-264489-h1n9ywbd	142	18	the	the	DT
cord-264489-h1n9ywbd	142	19	SD	sd	NN
cord-264489-h1n9ywbd	142	20	.	.	.
cord-264489-h1n9ywbd	143	1	greater	great	JJR
cord-264489-h1n9ywbd	143	2	(	(	-LRB-
cord-264489-h1n9ywbd	143	3	3.16Å	3.16å	CD
cord-264489-h1n9ywbd	143	4	)	)	-RRB-
cord-264489-h1n9ywbd	144	1	than	than	IN
cord-264489-h1n9ywbd	144	2	3WO2	3wo2	LS
cord-264489-h1n9ywbd	144	3	(	(	-LRB-
cord-264489-h1n9ywbd	144	4	2.47Å	2.47Å	NNP
cord-264489-h1n9ywbd	144	5	)	)	-RRB-
cord-264489-h1n9ywbd	144	6	.	.	.
cord-264489-h1n9ywbd	145	1	The	the	DT
cord-264489-h1n9ywbd	145	2	first	first	JJ
cord-264489-h1n9ywbd	145	3	0.6	0.6	CD
cord-264489-h1n9ywbd	145	4	ns	ns	XX
cord-264489-h1n9ywbd	145	5	of	of	IN
cord-264489-h1n9ywbd	145	6	the	the	DT
cord-264489-h1n9ywbd	145	7	simulation	simulation	NN
cord-264489-h1n9ywbd	145	8	was	be	VBD
cord-264489-h1n9ywbd	145	9	skipped	skip	VBN
cord-264489-h1n9ywbd	145	10	for	for	IN
cord-264489-h1n9ywbd	145	11	averaging	average	VBG
cord-264489-h1n9ywbd	145	12	as	as	IN
cord-264489-h1n9ywbd	145	13	initial	initial	JJ
cord-264489-h1n9ywbd	145	14	sampling	sampling	NN
cord-264489-h1n9ywbd	145	15	indicated	indicate	VBD
cord-264489-h1n9ywbd	145	16	a	a	DT
cord-264489-h1n9ywbd	145	17	steep	steep	JJ
cord-264489-h1n9ywbd	145	18	rise	rise	NN
cord-264489-h1n9ywbd	145	19	owing	owe	VBG
cord-264489-h1n9ywbd	145	20	to	to	IN
cord-264489-h1n9ywbd	145	21	the	the	DT
cord-264489-h1n9ywbd	145	22	process	process	NN
cord-264489-h1n9ywbd	145	23	of	of	IN
cord-264489-h1n9ywbd	145	24	protein	protein	NN
cord-264489-h1n9ywbd	145	25	-	-	HYPH
cord-264489-h1n9ywbd	145	26	unfolding	unfolding	NN
cord-264489-h1n9ywbd	145	27	.	.	.
cord-264489-h1n9ywbd	146	1	These	these	DT
cord-264489-h1n9ywbd	146	2	observations	observation	NNS
cord-264489-h1n9ywbd	146	3	gathered	gather	VBD
cord-264489-h1n9ywbd	146	4	from	from	IN
cord-264489-h1n9ywbd	146	5	plot	plot	NN
cord-264489-h1n9ywbd	146	6	6A	6a	CD
cord-264489-h1n9ywbd	146	7	lead	lead	VB
cord-264489-h1n9ywbd	146	8	us	-PRON-	PRP
cord-264489-h1n9ywbd	146	9	to	to	TO
cord-264489-h1n9ywbd	146	10	conclude	conclude	VB
cord-264489-h1n9ywbd	146	11	that	that	IN
cord-264489-h1n9ywbd	146	12	,	,	,
cord-264489-h1n9ywbd	146	13	apo	apo	NNP
cord-264489-h1n9ywbd	146	14	ligand	ligand	NNP
cord-264489-h1n9ywbd	146	15	3WO2	3wo2	CD
cord-264489-h1n9ywbd	146	16	is	be	VBZ
cord-264489-h1n9ywbd	146	17	more	more	RBR
cord-264489-h1n9ywbd	146	18	stable	stable	JJ
cord-264489-h1n9ywbd	146	19	than	than	IN
cord-264489-h1n9ywbd	146	20	1J0S.	1j0s.	CD
cord-264489-h1n9ywbd	147	1	The	the	DT
cord-264489-h1n9ywbd	147	2	undefined	undefined	JJ
cord-264489-h1n9ywbd	147	3	loop	loop	NN
cord-264489-h1n9ywbd	147	4	structure	structure	NN
cord-264489-h1n9ywbd	147	5	and	and	CC
cord-264489-h1n9ywbd	147	6	Cys	Cys	NNP
cord-264489-h1n9ywbd	147	7	(	(	-LRB-
cord-264489-h1n9ywbd	147	8	-SH	-SH	NNS
cord-264489-h1n9ywbd	147	9	)	)	-RRB-
cord-264489-h1n9ywbd	147	10	residues	residue	NNS
cord-264489-h1n9ywbd	147	11	in	in	IN
cord-264489-h1n9ywbd	147	12	1J0S	1j0s	CD
cord-264489-h1n9ywbd	147	13	make	make	VB
cord-264489-h1n9ywbd	147	14	this	this	DT
cord-264489-h1n9ywbd	147	15	structure	structure	NN
cord-264489-h1n9ywbd	147	16	less	less	RBR
cord-264489-h1n9ywbd	147	17	stable	stable	JJ
cord-264489-h1n9ywbd	147	18	.	.	.
cord-264489-h1n9ywbd	148	1	Four	four	CD
cord-264489-h1n9ywbd	148	2	Cys	Cys	NNP
cord-264489-h1n9ywbd	148	3	(	(	-LRB-
cord-264489-h1n9ywbd	148	4	-SH	-SH	NNS
cord-264489-h1n9ywbd	148	5	)	)	-RRB-
cord-264489-h1n9ywbd	148	6	residues	residue	NNS
cord-264489-h1n9ywbd	148	7	also	also	RB
cord-264489-h1n9ywbd	148	8	exist	exist	VBP
cord-264489-h1n9ywbd	148	9	in	in	IN
cord-264489-h1n9ywbd	148	10	3WO2	3wo2	CD
cord-264489-h1n9ywbd	148	11	,	,	,
cord-264489-h1n9ywbd	148	12	where	where	WRB
cord-264489-h1n9ywbd	148	13	the	the	DT
cord-264489-h1n9ywbd	148	14	Cys76	Cys76	NNP
cord-264489-h1n9ywbd	148	15	and	and	CC
cord-264489-h1n9ywbd	148	16	Cys127	Cys127	NNP
cord-264489-h1n9ywbd	148	17	species	specie	NNS
cord-264489-h1n9ywbd	148	18	support	support	VBP
cord-264489-h1n9ywbd	148	19	sulfur	sulfur	NN
cord-264489-h1n9ywbd	148	20	-	-	HYPH
cord-264489-h1n9ywbd	148	21	pi	pi	NN
cord-264489-h1n9ywbd	148	22	interactions	interaction	NNS
cord-264489-h1n9ywbd	148	23	with	with	IN
cord-264489-h1n9ywbd	148	24	Tyr120	tyr120	ADD
cord-264489-h1n9ywbd	148	25	and	and	CC
cord-264489-h1n9ywbd	148	26	Phe134	phe134	CD
cord-264489-h1n9ywbd	148	27	,	,	,
cord-264489-h1n9ywbd	148	28	respectively	respectively	RB
cord-264489-h1n9ywbd	148	29	.	.	.
cord-264489-h1n9ywbd	149	1	These	these	DT
cord-264489-h1n9ywbd	149	2	sulfur	sulfur	NN
cord-264489-h1n9ywbd	149	3	-	-	HYPH
cord-264489-h1n9ywbd	149	4	pi	pi	NN
cord-264489-h1n9ywbd	149	5	interactions	interaction	NNS
cord-264489-h1n9ywbd	149	6	are	be	VBP
cord-264489-h1n9ywbd	149	7	absent	absent	JJ
cord-264489-h1n9ywbd	149	8	in	in	IN
cord-264489-h1n9ywbd	149	9	1J0S.	1j0s.	CD
cord-264489-h1n9ywbd	150	1	Though	though	IN
cord-264489-h1n9ywbd	150	2	the	the	DT
cord-264489-h1n9ywbd	150	3	Cys127-Phe134	Cys127-Phe134	NNP
cord-264489-h1n9ywbd	150	4	pair	pair	NN
cord-264489-h1n9ywbd	150	5	involves	involve	VBZ
cord-264489-h1n9ywbd	150	6	pi	pi	NN
cord-264489-h1n9ywbd	150	7	-	-	HYPH
cord-264489-h1n9ywbd	150	8	alkyl	alkyl	JJ
cord-264489-h1n9ywbd	150	9	interactions	interaction	NNS
cord-264489-h1n9ywbd	150	10	in	in	IN
cord-264489-h1n9ywbd	150	11	both	both	DT
cord-264489-h1n9ywbd	150	12	cases	case	NNS
cord-264489-h1n9ywbd	150	13	.	.	.
cord-264489-h1n9ywbd	151	1	Although	although	IN
cord-264489-h1n9ywbd	151	2	some	some	DT
cord-264489-h1n9ywbd	151	3	minor	minor	JJ
cord-264489-h1n9ywbd	151	4	variations	variation	NNS
cord-264489-h1n9ywbd	151	5	are	be	VBP
cord-264489-h1n9ywbd	151	6	observed	observe	VBN
cord-264489-h1n9ywbd	151	7	in	in	IN
cord-264489-h1n9ywbd	151	8	3WO2	3wo2	CD
cord-264489-h1n9ywbd	151	9	loop	loop	NN
cord-264489-h1n9ywbd	151	10	,	,	,
cord-264489-h1n9ywbd	151	11	overall	overall	RB
cord-264489-h1n9ywbd	151	12	it	-PRON-	PRP
cord-264489-h1n9ywbd	151	13	maintains	maintain	VBZ
cord-264489-h1n9ywbd	151	14	a	a	DT
cord-264489-h1n9ywbd	151	15	stable	stable	JJ
cord-264489-h1n9ywbd	151	16	nature	nature	NN
cord-264489-h1n9ywbd	151	17	.	.	.
cord-264489-h1n9ywbd	152	1	The	the	DT
cord-264489-h1n9ywbd	152	2	partial	partial	JJ
cord-264489-h1n9ywbd	152	3	conversion	conversion	NN
cord-264489-h1n9ywbd	152	4	of	of	IN
cord-264489-h1n9ywbd	152	5	turns	turn	NNS
cord-264489-h1n9ywbd	152	6	into	into	IN
cord-264489-h1n9ywbd	152	7	-helices	-helices	NNPS
cord-264489-h1n9ywbd	152	8	in	in	IN
cord-264489-h1n9ywbd	152	9	3WO2	3wo2	CD
cord-264489-h1n9ywbd	152	10	strengthens	strengthen	VBZ
cord-264489-h1n9ywbd	152	11	and	and	CC
cord-264489-h1n9ywbd	152	12	stabilizes	stabilize	VBZ
cord-264489-h1n9ywbd	152	13	this	this	DT
cord-264489-h1n9ywbd	152	14	structure	structure	NN
cord-264489-h1n9ywbd	152	15	.	.	.
cord-264489-h1n9ywbd	153	1	The	the	DT
cord-264489-h1n9ywbd	153	2	undefined	undefined	JJ
cord-264489-h1n9ywbd	153	3	loop	loop	NN
cord-264489-h1n9ywbd	153	4	region	region	NN
cord-264489-h1n9ywbd	153	5	in	in	IN
cord-264489-h1n9ywbd	153	6	1J0S	1j0s	CD
cord-264489-h1n9ywbd	153	7	is	be	VBZ
cord-264489-h1n9ywbd	153	8	relatively	relatively	RB
cord-264489-h1n9ywbd	153	9	less	less	RBR
cord-264489-h1n9ywbd	153	10	stable	stable	JJ
cord-264489-h1n9ywbd	153	11	.	.	.
cord-264489-h1n9ywbd	154	1	For	for	IN
cord-264489-h1n9ywbd	154	2	the	the	DT
cord-264489-h1n9ywbd	154	3	ligand	ligand	NN
cord-264489-h1n9ywbd	154	4	bound	bind	VBN
cord-264489-h1n9ywbd	154	5	ternary	ternary	JJ
cord-264489-h1n9ywbd	154	6	structure	structure	NN
cord-264489-h1n9ywbd	154	7	3WO4	3wo4	CD
cord-264489-h1n9ywbd	154	8	,	,	,
cord-264489-h1n9ywbd	154	9	the	the	DT
cord-264489-h1n9ywbd	154	10			NNP
cord-264489-h1n9ywbd	154	11	receptor	receptor	NN
cord-264489-h1n9ywbd	154	12	exhibit	exhibit	NN
cord-264489-h1n9ywbd	154	13	strong	strong	JJ
cord-264489-h1n9ywbd	154	14	RMSD	RMSD	NNP
cord-264489-h1n9ywbd	154	15	variations	variation	NNS
cord-264489-h1n9ywbd	154	16	compared	compare	VBN
cord-264489-h1n9ywbd	154	17	to	to	IN
cord-264489-h1n9ywbd	154	18	those	those	DT
cord-264489-h1n9ywbd	154	19	of	of	IN
cord-264489-h1n9ywbd	154	20	the	the	DT
cord-264489-h1n9ywbd	154	21	ligand	ligand	NN
cord-264489-h1n9ywbd	154	22	and	and	NN
cord-264489-h1n9ywbd	154	23	receptor	receptor	NN
cord-264489-h1n9ywbd	154	24	structures	structure	NNS
cord-264489-h1n9ywbd	154	25	(	(	-LRB-
cord-264489-h1n9ywbd	154	26	data	datum	NNS
cord-264489-h1n9ywbd	154	27	not	not	RB
cord-264489-h1n9ywbd	154	28	shown	show	VBN
cord-264489-h1n9ywbd	154	29	)	)	-RRB-
cord-264489-h1n9ywbd	154	30	.	.	.
cord-264489-h1n9ywbd	155	1	The	the	DT
cord-264489-h1n9ywbd	155	2	larger	large	JJR
cord-264489-h1n9ywbd	155	3	interfacial	interfacial	JJ
cord-264489-h1n9ywbd	155	4	regions	region	NNS
cord-264489-h1n9ywbd	155	5	of	of	IN
cord-264489-h1n9ywbd	155	6	the	the	DT
cord-264489-h1n9ywbd	155	7			NNP
cord-264489-h1n9ywbd	155	8	receptor	receptor	NN
cord-264489-h1n9ywbd	155	9	(	(	-LRB-
cord-264489-h1n9ywbd	155	10	both	both	DT
cord-264489-h1n9ywbd	155	11	with	with	IN
cord-264489-h1n9ywbd	155	12	ligand	ligand	NN
cord-264489-h1n9ywbd	155	13	and	and	CC
cord-264489-h1n9ywbd	155	14	the	the	DT
cord-264489-h1n9ywbd	155	15			NNP
cord-264489-h1n9ywbd	155	16	receptor	receptor	NN
cord-264489-h1n9ywbd	155	17	)	)	-RRB-
cord-264489-h1n9ywbd	155	18	most	most	RBS
cord-264489-h1n9ywbd	155	19	likely	likely	RB
cord-264489-h1n9ywbd	155	20	boost	boost	VB
cord-264489-h1n9ywbd	155	21	the	the	DT
cord-264489-h1n9ywbd	155	22	latter	latter	NN
cord-264489-h1n9ywbd	155	23	's	's	POS
cord-264489-h1n9ywbd	155	24	stability	stability	NN
cord-264489-h1n9ywbd	155	25	,	,	,
cord-264489-h1n9ywbd	155	26	because	because	IN
cord-264489-h1n9ywbd	155	27	the	the	DT
cord-264489-h1n9ywbd	155	28	stronger	strong	JJR
cord-264489-h1n9ywbd	155	29	inter	inter	JJ
cord-264489-h1n9ywbd	155	30	-	-	JJ
cord-264489-h1n9ywbd	155	31	subunit	subunit	JJ
cord-264489-h1n9ywbd	155	32	interactions	interaction	NNS
cord-264489-h1n9ywbd	155	33	operate	operate	VBP
cord-264489-h1n9ywbd	155	34	in	in	IN
cord-264489-h1n9ywbd	155	35	these	these	DT
cord-264489-h1n9ywbd	155	36	regions	region	NNS
cord-264489-h1n9ywbd	155	37	.	.	.
cord-264489-h1n9ywbd	156	1	The	the	DT
cord-264489-h1n9ywbd	156	2	existence	existence	NN
cord-264489-h1n9ywbd	156	3	of	of	IN
cord-264489-h1n9ywbd	156	4	three	three	CD
cord-264489-h1n9ywbd	156	5	Cys	Cys	NNP
cord-264489-h1n9ywbd	156	6	residues	residue	NNS
cord-264489-h1n9ywbd	156	7	in	in	IN
cord-264489-h1n9ywbd	156	8	the	the	DT
cord-264489-h1n9ywbd	156	9			NNP
cord-264489-h1n9ywbd	156	10	receptor	receptor	NN
cord-264489-h1n9ywbd	156	11	could	could	MD
cord-264489-h1n9ywbd	156	12	be	be	VB
cord-264489-h1n9ywbd	156	13	attributed	attribute	VBN
cord-264489-h1n9ywbd	156	14	to	to	IN
cord-264489-h1n9ywbd	156	15	the	the	DT
cord-264489-h1n9ywbd	156	16	latter	latter	JJ
cord-264489-h1n9ywbd	156	17	's	's	POS
cord-264489-h1n9ywbd	156	18	unstable	unstable	JJ
cord-264489-h1n9ywbd	156	19	nature	nature	NN
cord-264489-h1n9ywbd	156	20	.	.	.
cord-264489-h1n9ywbd	157	1	The	the	DT
cord-264489-h1n9ywbd	157	2	presence	presence	NN
cord-264489-h1n9ywbd	157	3	of	of	IN
cord-264489-h1n9ywbd	157	4	surface	surface	NN
cord-264489-h1n9ywbd	157	5	exposed	expose	VBN
cord-264489-h1n9ywbd	157	6	Cys	Cys	NNP
cord-264489-h1n9ywbd	157	7	in	in	IN
cord-264489-h1n9ywbd	157	8	the	the	DT
cord-264489-h1n9ywbd	157	9	IL-18R	IL-18R	NNP
cord-264489-h1n9ywbd	157	10	receptor	receptor	NN
cord-264489-h1n9ywbd	157	11	chain	chain	NN
cord-264489-h1n9ywbd	157	12	may	may	MD
cord-264489-h1n9ywbd	157	13	also	also	RB
cord-264489-h1n9ywbd	157	14	be	be	VB
cord-264489-h1n9ywbd	157	15	accountable	accountable	JJ
cord-264489-h1n9ywbd	157	16	for	for	IN
cord-264489-h1n9ywbd	157	17	the	the	DT
cord-264489-h1n9ywbd	157	18	-chain	-chain	NNP
cord-264489-h1n9ywbd	157	19	's	's	POS
cord-264489-h1n9ywbd	157	20	higher	high	JJR
cord-264489-h1n9ywbd	157	21	instability	instability	NN
cord-264489-h1n9ywbd	157	22	.	.	.
cord-264489-h1n9ywbd	158	1	It	-PRON-	PRP
cord-264489-h1n9ywbd	158	2	is	be	VBZ
cord-264489-h1n9ywbd	158	3	possible	possible	JJ
cord-264489-h1n9ywbd	158	4	that	that	IN
cord-264489-h1n9ywbd	158	5	,	,	,
cord-264489-h1n9ywbd	158	6	these	these	DT
cord-264489-h1n9ywbd	158	7	fluctuations	fluctuation	NNS
cord-264489-h1n9ywbd	158	8	in	in	IN
cord-264489-h1n9ywbd	158	9	the	the	DT
cord-264489-h1n9ywbd	158	10			NNP
cord-264489-h1n9ywbd	158	11	J	J	NNP
cord-264489-h1n9ywbd	158	12	o	o	NN
cord-264489-h1n9ywbd	158	13	u	u	NN
cord-264489-h1n9ywbd	158	14	r	r	NN
cord-264489-h1n9ywbd	158	15	n	n	NN
cord-264489-h1n9ywbd	158	16	a	a	DT
cord-264489-h1n9ywbd	158	17	l	l	NN
cord-264489-h1n9ywbd	158	18	P	p	NN
cord-264489-h1n9ywbd	158	19	r	r	NN
cord-264489-h1n9ywbd	158	20	e	e	NN
cord-264489-h1n9ywbd	158	21	-p	-p	NN
cord-264489-h1n9ywbd	158	22	r	r	NN
cord-264489-h1n9ywbd	158	23	o	o	NN
cord-264489-h1n9ywbd	158	24	o	o	NN
cord-264489-h1n9ywbd	159	1	f	f	NNP
cord-264489-h1n9ywbd	159	2	receptor	receptor	NN
cord-264489-h1n9ywbd	159	3	(	(	-LRB-
cord-264489-h1n9ywbd	159	4	Fig	Fig	NNP
cord-264489-h1n9ywbd	159	5	.	.	.
cord-264489-h1n9ywbd	159	6	6B	6b	CD
cord-264489-h1n9ywbd	159	7	)	)	-RRB-
cord-264489-h1n9ywbd	160	1	cause	cause	VB
cord-264489-h1n9ywbd	160	2	the	the	DT
cord-264489-h1n9ywbd	160	3	overall	overall	JJ
cord-264489-h1n9ywbd	160	4	instability	instability	NN
cord-264489-h1n9ywbd	160	5	of	of	IN
cord-264489-h1n9ywbd	160	6	the	the	DT
cord-264489-h1n9ywbd	160	7	ligand	ligand	NN
cord-264489-h1n9ywbd	160	8	bound	bind	VBN
cord-264489-h1n9ywbd	160	9	receptor	receptor	NN
cord-264489-h1n9ywbd	160	10	's	's	POS
cord-264489-h1n9ywbd	160	11	trimeric	trimeric	JJ
cord-264489-h1n9ywbd	160	12	structure	structure	NN
cord-264489-h1n9ywbd	160	13	(	(	-LRB-
cord-264489-h1n9ywbd	160	14	Fig	Fig	NNP
cord-264489-h1n9ywbd	160	15	.	.	.
cord-264489-h1n9ywbd	160	16	6A	6a	CD
cord-264489-h1n9ywbd	160	17	)	)	-RRB-
cord-264489-h1n9ywbd	160	18	.	.	.
cord-264489-h1n9ywbd	161	1	SD	SD	NNP
cord-264489-h1n9ywbd	161	2	Fig	Fig	NNP
cord-264489-h1n9ywbd	161	3	.	.	.
cord-264489-h1n9ywbd	162	1	S5	S5	NNP
cord-264489-h1n9ywbd	162	2	shows	show	VBZ
cord-264489-h1n9ywbd	162	3	the	the	DT
cord-264489-h1n9ywbd	162	4	superposed	superposed	JJ
cord-264489-h1n9ywbd	162	5	Cys	Cys	NNP
cord-264489-h1n9ywbd	162	6	and	and	CC
cord-264489-h1n9ywbd	162	7	the	the	DT
cord-264489-h1n9ywbd	162	8	disulfides	disulfide	NNS
cord-264489-h1n9ywbd	162	9	within	within	IN
cord-264489-h1n9ywbd	162	10	the	the	DT
cord-264489-h1n9ywbd	162	11	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	162	12	systems	system	NNS
cord-264489-h1n9ywbd	162	13	.	.	.
cord-264489-h1n9ywbd	163	1	A	a	DT
cord-264489-h1n9ywbd	163	2	change	change	NN
cord-264489-h1n9ywbd	163	3	from	from	IN
cord-264489-h1n9ywbd	163	4	3	3	CD
cord-264489-h1n9ywbd	163	5	-	-	SYM
cord-264489-h1n9ywbd	163	6	10	10	CD
cord-264489-h1n9ywbd	163	7	helices	helix	NNS
cord-264489-h1n9ywbd	163	8	to	to	TO
cord-264489-h1n9ywbd	163	9	turn	turn	VB
cord-264489-h1n9ywbd	163	10	is	be	VBZ
cord-264489-h1n9ywbd	163	11	observed	observe	VBN
cord-264489-h1n9ywbd	163	12	around	around	IN
cord-264489-h1n9ywbd	163	13	residues	residue	NNS
cord-264489-h1n9ywbd	163	14	41	41	CD
cord-264489-h1n9ywbd	163	15	-	-	SYM
cord-264489-h1n9ywbd	163	16	44	44	CD
cord-264489-h1n9ywbd	163	17	,	,	,
cord-264489-h1n9ywbd	163	18	within	within	IN
cord-264489-h1n9ywbd	163	19	the	the	DT
cord-264489-h1n9ywbd	163	20	ligand	ligand	NN
cord-264489-h1n9ywbd	163	21	bound	bind	VBN
cord-264489-h1n9ywbd	163	22	form	form	NN
cord-264489-h1n9ywbd	163	23	of	of	IN
cord-264489-h1n9ywbd	163	24	the	the	DT
cord-264489-h1n9ywbd	163	25	3WO3	3wo3	CD
cord-264489-h1n9ywbd	163	26	ligand	ligand	NN
cord-264489-h1n9ywbd	163	27	.	.	.
cord-264489-h1n9ywbd	164	1	Like	like	IN
cord-264489-h1n9ywbd	164	2	the	the	DT
cord-264489-h1n9ywbd	164	3	case	case	NN
cord-264489-h1n9ywbd	164	4	of	of	IN
cord-264489-h1n9ywbd	164	5	3WO2	3wo2	CD
cord-264489-h1n9ywbd	164	6	,	,	,
cord-264489-h1n9ywbd	164	7	in	in	IN
cord-264489-h1n9ywbd	164	8	the	the	DT
cord-264489-h1n9ywbd	164	9	3WO3	3wo3	CD
cord-264489-h1n9ywbd	164	10	ligand	ligand	NN
cord-264489-h1n9ywbd	164	11	,	,	,
cord-264489-h1n9ywbd	164	12	the	the	DT
cord-264489-h1n9ywbd	164	13	residues	residue	NNS
cord-264489-h1n9ywbd	164	14	around	around	IN
cord-264489-h1n9ywbd	164	15	76	76	CD
cord-264489-h1n9ywbd	164	16	-	-	SYM
cord-264489-h1n9ywbd	164	17	81	81	CD
cord-264489-h1n9ywbd	164	18	also	also	RB
cord-264489-h1n9ywbd	164	19	persistently	persistently	RB
cord-264489-h1n9ywbd	164	20	change	change	VBP
cord-264489-h1n9ywbd	164	21	from	from	IN
cord-264489-h1n9ywbd	164	22	3	3	CD
cord-264489-h1n9ywbd	164	23	-	-	SYM
cord-264489-h1n9ywbd	164	24	10	10	CD
cord-264489-h1n9ywbd	164	25	helical	helical	JJ
cord-264489-h1n9ywbd	164	26	structure	structure	NN
cord-264489-h1n9ywbd	164	27	to	to	TO
cord-264489-h1n9ywbd	164	28	turn	turn	VB
cord-264489-h1n9ywbd	164	29	.	.	.
cord-264489-h1n9ywbd	165	1	Aside	aside	RB
cord-264489-h1n9ywbd	165	2	from	from	IN
cord-264489-h1n9ywbd	165	3	this	this	DT
cord-264489-h1n9ywbd	165	4	,	,	,
cord-264489-h1n9ywbd	165	5	no	no	DT
cord-264489-h1n9ywbd	165	6	other	other	JJ
cord-264489-h1n9ywbd	165	7	major	major	JJ
cord-264489-h1n9ywbd	165	8	changes	change	NNS
cord-264489-h1n9ywbd	165	9	are	be	VBP
cord-264489-h1n9ywbd	165	10	observed	observe	VBN
cord-264489-h1n9ywbd	165	11	in	in	IN
cord-264489-h1n9ywbd	165	12	this	this	DT
cord-264489-h1n9ywbd	165	13	case	case	NN
cord-264489-h1n9ywbd	165	14	,	,	,
cord-264489-h1n9ywbd	165	15	and	and	CC
cord-264489-h1n9ywbd	165	16	overall	overall	RB
cord-264489-h1n9ywbd	165	17	the	the	DT
cord-264489-h1n9ywbd	165	18	ligand	ligand	NN
cord-264489-h1n9ywbd	165	19	in	in	IN
cord-264489-h1n9ywbd	165	20	3WO3	3wo3	CD
cord-264489-h1n9ywbd	165	21	seems	seem	VBZ
cord-264489-h1n9ywbd	165	22	slightly	slightly	RB
cord-264489-h1n9ywbd	165	23	more	more	RBR
cord-264489-h1n9ywbd	165	24	stable	stable	JJ
cord-264489-h1n9ywbd	165	25	than	than	IN
cord-264489-h1n9ywbd	165	26	that	that	DT
cord-264489-h1n9ywbd	165	27	of	of	IN
cord-264489-h1n9ywbd	165	28	3WO2	3wo2	CD
cord-264489-h1n9ywbd	165	29	.	.	.
cord-264489-h1n9ywbd	166	1	The	the	DT
cord-264489-h1n9ywbd	166	2	receptor	receptor	NN
cord-264489-h1n9ywbd	166	3	residues	residue	VBZ
cord-264489-h1n9ywbd	166	4	256	256	CD
cord-264489-h1n9ywbd	166	5	-	-	HYPH
cord-264489-h1n9ywbd	166	6	261	261	CD
cord-264489-h1n9ywbd	166	7	and	and	CC
cord-264489-h1n9ywbd	166	8	282	282	CD
cord-264489-h1n9ywbd	166	9	-	-	SYM
cord-264489-h1n9ywbd	166	10	295	295	CD
cord-264489-h1n9ywbd	166	11	in	in	IN
cord-264489-h1n9ywbd	166	12	the	the	DT
cord-264489-h1n9ywbd	166	13	linker	linker	NN
cord-264489-h1n9ywbd	166	14	-	-	HYPH
cord-264489-h1n9ywbd	166	15	turn	turn	NN
cord-264489-h1n9ywbd	166	16	region	region	NN
cord-264489-h1n9ywbd	166	17	of	of	IN
cord-264489-h1n9ywbd	166	18	3WO3	3wo3	CD
cord-264489-h1n9ywbd	166	19	show	show	VBP
cord-264489-h1n9ywbd	166	20	a	a	DT
cord-264489-h1n9ywbd	166	21	few	few	JJ
cord-264489-h1n9ywbd	166	22	changes	change	NNS
cord-264489-h1n9ywbd	166	23	from	from	IN
cord-264489-h1n9ywbd	166	24	turn	turn	NN
cord-264489-h1n9ywbd	166	25	to	to	IN
cord-264489-h1n9ywbd	166	26	coils	coil	NNS
cord-264489-h1n9ywbd	166	27	and	and	CC
cord-264489-h1n9ywbd	166	28	3	3	CD
cord-264489-h1n9ywbd	166	29	-	-	SYM
cord-264489-h1n9ywbd	166	30	10	10	CD
cord-264489-h1n9ywbd	166	31	helices	helix	NNS
cord-264489-h1n9ywbd	166	32	respectively	respectively	RB
cord-264489-h1n9ywbd	166	33	.	.	.
cord-264489-h1n9ywbd	167	1	Nevertheless	nevertheless	RB
cord-264489-h1n9ywbd	167	2	,	,	,
cord-264489-h1n9ywbd	167	3	within	within	IN
cord-264489-h1n9ywbd	167	4	the	the	DT
cord-264489-h1n9ywbd	167	5	receptor	receptor	NN
cord-264489-h1n9ywbd	167	6	structure	structure	NN
cord-264489-h1n9ywbd	167	7	,	,	,
cord-264489-h1n9ywbd	167	8	the	the	DT
cord-264489-h1n9ywbd	167	9	prominent	prominent	JJ
cord-264489-h1n9ywbd	167	10	loop	loop	NN
cord-264489-h1n9ywbd	167	11	region	region	NN
cord-264489-h1n9ywbd	167	12	207	207	CD
cord-264489-h1n9ywbd	167	13	-	-	SYM
cord-264489-h1n9ywbd	167	14	215	215	CD
cord-264489-h1n9ywbd	167	15	seems	seem	VBZ
cord-264489-h1n9ywbd	167	16	rather	rather	RB
cord-264489-h1n9ywbd	167	17	stable	stable	JJ
cord-264489-h1n9ywbd	167	18	.	.	.
cord-264489-h1n9ywbd	168	1	It	-PRON-	PRP
cord-264489-h1n9ywbd	168	2	is	be	VBZ
cord-264489-h1n9ywbd	168	3	likely	likely	JJ
cord-264489-h1n9ywbd	168	4	that	that	IN
cord-264489-h1n9ywbd	168	5	,	,	,
cord-264489-h1n9ywbd	168	6	the	the	DT
cord-264489-h1n9ywbd	168	7	protein	protein	NN
cord-264489-h1n9ywbd	168	8	-	-	HYPH
cord-264489-h1n9ywbd	168	9	protein	protein	NN
cord-264489-h1n9ywbd	168	10	inter	inter	JJ
cord-264489-h1n9ywbd	168	11	-	-	JJ
cord-264489-h1n9ywbd	168	12	subunit	subunit	JJ
cord-264489-h1n9ywbd	168	13	interactions	interaction	NNS
cord-264489-h1n9ywbd	168	14	act	act	VBP
cord-264489-h1n9ywbd	168	15	to	to	TO
cord-264489-h1n9ywbd	168	16	stabilize	stabilize	VB
cord-264489-h1n9ywbd	168	17	this	this	DT
cord-264489-h1n9ywbd	168	18	loop	loop	NN
cord-264489-h1n9ywbd	168	19	.	.	.
cord-264489-h1n9ywbd	169	1	From	from	IN
cord-264489-h1n9ywbd	169	2	the	the	DT
cord-264489-h1n9ywbd	169	3	structure	structure	NN
cord-264489-h1n9ywbd	169	4	of	of	IN
cord-264489-h1n9ywbd	169	5	3WO3	3wo3	CD
cord-264489-h1n9ywbd	169	6	it	-PRON-	PRP
cord-264489-h1n9ywbd	169	7	is	be	VBZ
cord-264489-h1n9ywbd	169	8	also	also	RB
cord-264489-h1n9ywbd	169	9	clear	clear	JJ
cord-264489-h1n9ywbd	169	10	that	that	IN
cord-264489-h1n9ywbd	169	11	the	the	DT
cord-264489-h1n9ywbd	169	12	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	169	13	fits	fit	VBZ
cord-264489-h1n9ywbd	169	14	very	very	RB
cord-264489-h1n9ywbd	169	15	well	well	RB
cord-264489-h1n9ywbd	169	16	within	within	IN
cord-264489-h1n9ywbd	169	17	the	the	DT
cord-264489-h1n9ywbd	169	18	typical	typical	JJ
cord-264489-h1n9ywbd	169	19	ligand	ligand	NN
cord-264489-h1n9ywbd	169	20	binding	bind	VBG
cord-264489-h1n9ywbd	169	21	pocket	pocket	NN
cord-264489-h1n9ywbd	169	22	by	by	IN
cord-264489-h1n9ywbd	169	23	surrounding	surround	VBG
cord-264489-h1n9ywbd	169	24	receptor	receptor	NN
cord-264489-h1n9ywbd	169	25	domains	domain	NNS
cord-264489-h1n9ywbd	169	26	.	.	.
cord-264489-h1n9ywbd	170	1	Certain	certain	JJ
cord-264489-h1n9ywbd	170	2	accommodative	accommodative	JJ
cord-264489-h1n9ywbd	170	3	arrangements	arrangement	NNS
cord-264489-h1n9ywbd	170	4	taking	take	VBG
cord-264489-h1n9ywbd	170	5	place	place	NN
cord-264489-h1n9ywbd	170	6	between	between	IN
cord-264489-h1n9ywbd	170	7	the	the	DT
cord-264489-h1n9ywbd	170	8	ligand	ligand	NN
cord-264489-h1n9ywbd	170	9	and	and	CC
cord-264489-h1n9ywbd	170	10	the	the	DT
cord-264489-h1n9ywbd	170	11	receptor	receptor	NN
cord-264489-h1n9ywbd	170	12	's	's	POS
cord-264489-h1n9ywbd	170	13	three	three	CD
cord-264489-h1n9ywbd	170	14	different	different	JJ
cord-264489-h1n9ywbd	170	15	domains	domain	NNS
cord-264489-h1n9ywbd	170	16	may	may	MD
cord-264489-h1n9ywbd	170	17	make	make	VB
cord-264489-h1n9ywbd	170	18	the	the	DT
cord-264489-h1n9ywbd	170	19	corresponding	correspond	VBG
cord-264489-h1n9ywbd	170	20	region	region	NN
cord-264489-h1n9ywbd	170	21	further	further	RB
cord-264489-h1n9ywbd	170	22	stable	stable	JJ
cord-264489-h1n9ywbd	170	23	.	.	.
cord-264489-h1n9ywbd	171	1	It	-PRON-	PRP
cord-264489-h1n9ywbd	171	2	is	be	VBZ
cord-264489-h1n9ywbd	171	3	also	also	RB
cord-264489-h1n9ywbd	171	4	evident	evident	JJ
cord-264489-h1n9ywbd	171	5	from	from	IN
cord-264489-h1n9ywbd	171	6	Fig	Fig	NNP
cord-264489-h1n9ywbd	171	7	.	.	.
cord-264489-h1n9ywbd	172	1	8	8	CD
cord-264489-h1n9ywbd	173	1	that	that	IN
cord-264489-h1n9ywbd	173	2	,	,	,
cord-264489-h1n9ywbd	173	3	the	the	DT
cord-264489-h1n9ywbd	173	4	ligand	ligand	NN
cord-264489-h1n9ywbd	173	5	is	be	VBZ
cord-264489-h1n9ywbd	173	6	a	a	DT
cord-264489-h1n9ywbd	173	7	bit	bit	NN
cord-264489-h1n9ywbd	173	8	more	more	RBR
cord-264489-h1n9ywbd	173	9	stable	stable	JJ
cord-264489-h1n9ywbd	173	10	in	in	IN
cord-264489-h1n9ywbd	173	11	the	the	DT
cord-264489-h1n9ywbd	173	12	receptor	receptor	NN
cord-264489-h1n9ywbd	173	13	bound	bind	VBN
cord-264489-h1n9ywbd	173	14	form	form	NN
cord-264489-h1n9ywbd	173	15	of	of	IN
cord-264489-h1n9ywbd	173	16	3WO3	3wo3	CD
cord-264489-h1n9ywbd	173	17	,	,	,
cord-264489-h1n9ywbd	173	18	as	as	IN
cord-264489-h1n9ywbd	173	19	compared	compare	VBN
cord-264489-h1n9ywbd	173	20	to	to	IN
cord-264489-h1n9ywbd	173	21	the	the	DT
cord-264489-h1n9ywbd	173	22	corresponding	corresponding	JJ
cord-264489-h1n9ywbd	173	23	case	case	NN
cord-264489-h1n9ywbd	173	24	of	of	IN
cord-264489-h1n9ywbd	173	25	the	the	DT
cord-264489-h1n9ywbd	173	26	apo	apo	NNP
cord-264489-h1n9ywbd	173	27	structure	structure	NN
cord-264489-h1n9ywbd	173	28	3WO2	3wo2	CD
cord-264489-h1n9ywbd	173	29	.	.	.
cord-264489-h1n9ywbd	174	1	The	the	DT
cord-264489-h1n9ywbd	174	2	secondary	secondary	JJ
cord-264489-h1n9ywbd	174	3	structure	structure	NN
cord-264489-h1n9ywbd	174	4	of	of	IN
cord-264489-h1n9ywbd	174	5	3WO4	3wo4	CD
cord-264489-h1n9ywbd	174	6	ligand	ligand	NN
cord-264489-h1n9ywbd	174	7	has	have	VBZ
cord-264489-h1n9ywbd	174	8	an	an	DT
cord-264489-h1n9ywbd	174	9	approximately	approximately	RB
cord-264489-h1n9ywbd	174	10	comparable	comparable	JJ
cord-264489-h1n9ywbd	174	11	or	or	CC
cord-264489-h1n9ywbd	174	12	marginally	marginally	RB
cord-264489-h1n9ywbd	174	13	higher	high	JJR
cord-264489-h1n9ywbd	174	14	stability	stability	NN
cord-264489-h1n9ywbd	174	15	with	with	IN
cord-264489-h1n9ywbd	174	16	respect	respect	NN
cord-264489-h1n9ywbd	174	17	to	to	IN
cord-264489-h1n9ywbd	174	18	that	that	DT
cord-264489-h1n9ywbd	174	19	of	of	IN
cord-264489-h1n9ywbd	174	20	the	the	DT
cord-264489-h1n9ywbd	174	21	3WO3	3wo3	CD
cord-264489-h1n9ywbd	174	22	ligand	ligand	NN
cord-264489-h1n9ywbd	174	23	.	.	.
cord-264489-h1n9ywbd	175	1	However	however	RB
cord-264489-h1n9ywbd	175	2	,	,	,
cord-264489-h1n9ywbd	175	3	the	the	DT
cord-264489-h1n9ywbd	175	4	3WO4	3wo4	CD
cord-264489-h1n9ywbd	175	5	ligand	ligand	NN
cord-264489-h1n9ywbd	175	6	residues	residue	NNS
cord-264489-h1n9ywbd	175	7	66	66	CD
cord-264489-h1n9ywbd	175	8	-	-	SYM
cord-264489-h1n9ywbd	175	9	71	71	CD
cord-264489-h1n9ywbd	175	10	show	show	VBP
cord-264489-h1n9ywbd	175	11	some	some	DT
cord-264489-h1n9ywbd	175	12	additional	additional	JJ
cord-264489-h1n9ywbd	175	13	variability	variability	NN
cord-264489-h1n9ywbd	175	14	from	from	IN
cord-264489-h1n9ywbd	175	15	-sheets	-sheets	CD
cord-264489-h1n9ywbd	175	16	to	to	IN
cord-264489-h1n9ywbd	175	17	turns	turn	NNS
cord-264489-h1n9ywbd	175	18	.	.	.
cord-264489-h1n9ywbd	176	1	Nevertheless	nevertheless	RB
cord-264489-h1n9ywbd	176	2	,	,	,
cord-264489-h1n9ywbd	176	3	the	the	DT
cord-264489-h1n9ywbd	176	4	changes	change	NNS
cord-264489-h1n9ywbd	176	5	that	that	WDT
cord-264489-h1n9ywbd	176	6	are	be	VBP
cord-264489-h1n9ywbd	176	7	observed	observe	VBN
cord-264489-h1n9ywbd	176	8	around	around	IN
cord-264489-h1n9ywbd	176	9	residue	residue	NN
cord-264489-h1n9ywbd	176	10	56	56	CD
cord-264489-h1n9ywbd	176	11	in	in	IN
cord-264489-h1n9ywbd	176	12	3WO3	3wo3	CD
cord-264489-h1n9ywbd	176	13	ligand	ligand	NN
cord-264489-h1n9ywbd	176	14	are	be	VBP
cord-264489-h1n9ywbd	176	15	absent	absent	JJ
cord-264489-h1n9ywbd	176	16	here	here	RB
cord-264489-h1n9ywbd	176	17	.	.	.
cord-264489-h1n9ywbd	177	1	The	the	DT
cord-264489-h1n9ywbd	177	2	secondary	secondary	JJ
cord-264489-h1n9ywbd	177	3	structural	structural	JJ
cord-264489-h1n9ywbd	177	4	changes	change	NNS
cord-264489-h1n9ywbd	177	5	of	of	IN
cord-264489-h1n9ywbd	177	6	the	the	DT
cord-264489-h1n9ywbd	177	7	ligand	ligand	NN
cord-264489-h1n9ywbd	177	8	within	within	IN
cord-264489-h1n9ywbd	177	9	the	the	DT
cord-264489-h1n9ywbd	177	10	ligand	ligand	NN
cord-264489-h1n9ywbd	177	11	bound	bind	VBN
cord-264489-h1n9ywbd	177	12	receptors	receptor	NNS
cord-264489-h1n9ywbd	177	13	are	be	VBP
cord-264489-h1n9ywbd	177	14	plotted	plot	VBN
cord-264489-h1n9ywbd	177	15	in	in	IN
cord-264489-h1n9ywbd	177	16	SD	SD	NNP
cord-264489-h1n9ywbd	177	17	Fig	Fig	NNP
cord-264489-h1n9ywbd	177	18	.	.	.
cord-264489-h1n9ywbd	177	19	S8	S8	NNP
cord-264489-h1n9ywbd	177	20	.	.	.
cord-264489-h1n9ywbd	178	1	From	from	IN
cord-264489-h1n9ywbd	178	2	Figs	fig	NNS
cord-264489-h1n9ywbd	178	3	.	.	.
cord-264489-h1n9ywbd	179	1	8	8	CD
cord-264489-h1n9ywbd	179	2	and	and	CC
cord-264489-h1n9ywbd	179	3	S8	S8	NNP
cord-264489-h1n9ywbd	179	4	,	,	,
cord-264489-h1n9ywbd	179	5	it	-PRON-	PRP
cord-264489-h1n9ywbd	179	6	is	be	VBZ
cord-264489-h1n9ywbd	179	7	evident	evident	JJ
cord-264489-h1n9ywbd	179	8	that	that	IN
cord-264489-h1n9ywbd	179	9	,	,	,
cord-264489-h1n9ywbd	179	10	the	the	DT
cord-264489-h1n9ywbd	179	11	ligand	ligand	NN
cord-264489-h1n9ywbd	179	12	is	be	VBZ
cord-264489-h1n9ywbd	179	13	more	more	RBR
cord-264489-h1n9ywbd	179	14	stable	stable	JJ
cord-264489-h1n9ywbd	179	15	within	within	IN
cord-264489-h1n9ywbd	179	16	the	the	DT
cord-264489-h1n9ywbd	179	17	receptor	receptor	NN
cord-264489-h1n9ywbd	179	18	-	-	HYPH
cord-264489-h1n9ywbd	179	19	bound	bind	VBN
cord-264489-h1n9ywbd	179	20	forms	form	NNS
cord-264489-h1n9ywbd	179	21	than	than	IN
cord-264489-h1n9ywbd	179	22	in	in	IN
cord-264489-h1n9ywbd	179	23	its	-PRON-	PRP$
cord-264489-h1n9ywbd	179	24	apo	apo	NNP
cord-264489-h1n9ywbd	179	25	form	form	NN
cord-264489-h1n9ywbd	179	26	,	,	,
cord-264489-h1n9ywbd	179	27	and	and	CC
cord-264489-h1n9ywbd	179	28	that	that	IN
cord-264489-h1n9ywbd	179	29	correspondingly	correspondingly	RB
cord-264489-h1n9ywbd	179	30	,	,	,
cord-264489-h1n9ywbd	179	31	fewer	few	JJR
cord-264489-h1n9ywbd	179	32	conformational	conformational	JJ
cord-264489-h1n9ywbd	179	33	changes	change	NNS
cord-264489-h1n9ywbd	179	34	occur	occur	VBP
cord-264489-h1n9ywbd	179	35	within	within	IN
cord-264489-h1n9ywbd	179	36	the	the	DT
cord-264489-h1n9ywbd	179	37	ligand	ligand	NN
cord-264489-h1n9ywbd	179	38	of	of	IN
cord-264489-h1n9ywbd	179	39	3WO4	3wo4	CD
cord-264489-h1n9ywbd	179	40	upon	upon	IN
cord-264489-h1n9ywbd	179	41	receptor	receptor	NN
cord-264489-h1n9ywbd	179	42	binding	binding	NN
cord-264489-h1n9ywbd	179	43	.	.	.
cord-264489-h1n9ywbd	180	1	The	the	DT
cord-264489-h1n9ywbd	180	2	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	180	3	in	in	IN
cord-264489-h1n9ywbd	180	4	3WO4	3wo4	CD
cord-264489-h1n9ywbd	180	5	is	be	VBZ
cord-264489-h1n9ywbd	180	6	somewhat	somewhat	RB
cord-264489-h1n9ywbd	180	7	more	more	RBR
cord-264489-h1n9ywbd	180	8	stable	stable	JJ
cord-264489-h1n9ywbd	180	9	than	than	IN
cord-264489-h1n9ywbd	180	10	3WO3	3wo3	CD
cord-264489-h1n9ywbd	180	11	,	,	,
cord-264489-h1n9ywbd	180	12	even	even	RB
cord-264489-h1n9ywbd	180	13	though	though	IN
cord-264489-h1n9ywbd	180	14	the	the	DT
cord-264489-h1n9ywbd	180	15	overall	overall	JJ
cord-264489-h1n9ywbd	180	16	stability	stability	NN
cord-264489-h1n9ywbd	180	17	in	in	IN
cord-264489-h1n9ywbd	180	18	3WO3	3wo3	CD
cord-264489-h1n9ywbd	180	19	is	be	VBZ
cord-264489-h1n9ywbd	180	20	higher	high	JJR
cord-264489-h1n9ywbd	180	21	than	than	IN
cord-264489-h1n9ywbd	180	22	that	that	DT
cord-264489-h1n9ywbd	180	23	of	of	IN
cord-264489-h1n9ywbd	180	24	3WO4	3wo4	CD
cord-264489-h1n9ywbd	180	25	;	;	:
cord-264489-h1n9ywbd	180	26	the	the	DT
cord-264489-h1n9ywbd	180	27	relatively	relatively	RB
cord-264489-h1n9ywbd	180	28	higher	high	JJR
cord-264489-h1n9ywbd	180	29	interfacial	interfacial	JJ
cord-264489-h1n9ywbd	180	30	intersubunit	intersubunit	JJ
cord-264489-h1n9ywbd	180	31	interactions	interaction	NNS
cord-264489-h1n9ywbd	180	32	present	present	JJ
cord-264489-h1n9ywbd	180	33	in	in	IN
cord-264489-h1n9ywbd	180	34	3WO4	3wo4	CD
cord-264489-h1n9ywbd	180	35	ligand	ligand	NN
cord-264489-h1n9ywbd	180	36	may	may	MD
cord-264489-h1n9ywbd	180	37	be	be	VB
cord-264489-h1n9ywbd	180	38	responsible	responsible	JJ
cord-264489-h1n9ywbd	180	39	for	for	IN
cord-264489-h1n9ywbd	180	40	this	this	DT
cord-264489-h1n9ywbd	180	41	higher	high	JJR
cord-264489-h1n9ywbd	180	42	stability	stability	NN
cord-264489-h1n9ywbd	180	43	.	.	.
cord-264489-h1n9ywbd	181	1	The	the	DT
cord-264489-h1n9ywbd	181	2	maximum	maximum	JJ
cord-264489-h1n9ywbd	181	3	changeability	changeability	NN
cord-264489-h1n9ywbd	181	4	in	in	IN
cord-264489-h1n9ywbd	181	5	the	the	DT
cord-264489-h1n9ywbd	181	6	secondary	secondary	JJ
cord-264489-h1n9ywbd	181	7	structure	structure	NN
cord-264489-h1n9ywbd	181	8	is	be	VBZ
cord-264489-h1n9ywbd	181	9	observable	observable	JJ
cord-264489-h1n9ywbd	181	10	in	in	IN
cord-264489-h1n9ywbd	181	11	the	the	DT
cord-264489-h1n9ywbd	181	12	C	C	NNP
cord-264489-h1n9ywbd	181	13	subunit	subunit	NN
cord-264489-h1n9ywbd	181	14	Furthermore	furthermore	RB
cord-264489-h1n9ywbd	181	15	,	,	,
cord-264489-h1n9ywbd	181	16	along	along	IN
cord-264489-h1n9ywbd	181	17	with	with	IN
cord-264489-h1n9ywbd	181	18	several	several	JJ
cord-264489-h1n9ywbd	181	19	other	other	JJ
cord-264489-h1n9ywbd	181	20	cytokines	cytokine	NNS
cord-264489-h1n9ywbd	181	21	,	,	,
cord-264489-h1n9ywbd	181	22	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	181	23	can	can	MD
cord-264489-h1n9ywbd	181	24	be	be	VB
cord-264489-h1n9ywbd	181	25	used	use	VBN
cord-264489-h1n9ywbd	181	26	as	as	IN
cord-264489-h1n9ywbd	181	27	adjuvants	adjuvant	NNS
cord-264489-h1n9ywbd	181	28	with	with	IN
cord-264489-h1n9ywbd	181	29	HIV	HIV	NNP
cord-264489-h1n9ywbd	181	30	and	and	CC
cord-264489-h1n9ywbd	181	31	several	several	JJ
cord-264489-h1n9ywbd	181	32	other	other	JJ
cord-264489-h1n9ywbd	181	33	vaccines	vaccine	NNS
cord-264489-h1n9ywbd	181	34	(	(	-LRB-
cord-264489-h1n9ywbd	181	35	Bradney	Bradney	NNP
cord-264489-h1n9ywbd	181	36	et	et	NNP
cord-264489-h1n9ywbd	181	37	al	al	NNP
cord-264489-h1n9ywbd	181	38	.	.	.
cord-264489-h1n9ywbd	181	39	2002	2002	CD
cord-264489-h1n9ywbd	181	40	)	)	-RRB-
cord-264489-h1n9ywbd	181	41	.	.	.
cord-264489-h1n9ywbd	182	1	In	in	IN
cord-264489-h1n9ywbd	182	2	recent	recent	JJ
cord-264489-h1n9ywbd	182	3	years	year	NNS
cord-264489-h1n9ywbd	182	4	,	,	,
cord-264489-h1n9ywbd	182	5	due	due	IN
cord-264489-h1n9ywbd	182	6	to	to	IN
cord-264489-h1n9ywbd	182	7	outbreak	outbreak	NN
cord-264489-h1n9ywbd	182	8	of	of	IN
cord-264489-h1n9ywbd	182	9	SARS	SARS	NNP
cord-264489-h1n9ywbd	182	10	-	-	HYPH
cord-264489-h1n9ywbd	182	11	CoV-2	CoV-2	NNP
cord-264489-h1n9ywbd	182	12	pandemic	pandemic	NN
cord-264489-h1n9ywbd	182	13	,	,	,
cord-264489-h1n9ywbd	182	14	considerable	considerable	JJ
cord-264489-h1n9ywbd	182	15	attentions	attention	NNS
cord-264489-h1n9ywbd	182	16	have	have	VBP
cord-264489-h1n9ywbd	182	17	been	be	VBN
cord-264489-h1n9ywbd	182	18	directed	direct	VBN
cord-264489-h1n9ywbd	182	19	towards	towards	IN
cord-264489-h1n9ywbd	182	20	the	the	DT
cord-264489-h1n9ywbd	182	21	immunity	immunity	NN
cord-264489-h1n9ywbd	182	22	development	development	NN
cord-264489-h1n9ywbd	182	23	against	against	IN
cord-264489-h1n9ywbd	182	24	viral	viral	JJ
cord-264489-h1n9ywbd	182	25	pathogens	pathogen	NNS
cord-264489-h1n9ywbd	182	26	.	.	.
cord-264489-h1n9ywbd	183	1	The	the	DT
cord-264489-h1n9ywbd	183	2	present	present	JJ
cord-264489-h1n9ywbd	183	3	paper	paper	NN
cord-264489-h1n9ywbd	183	4	demonstrates	demonstrate	VBZ
cord-264489-h1n9ywbd	183	5	that	that	IN
cord-264489-h1n9ywbd	183	6	,	,	,
cord-264489-h1n9ywbd	183	7	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	183	8	itself	-PRON-	PRP
cord-264489-h1n9ywbd	183	9	is	be	VBZ
cord-264489-h1n9ywbd	183	10	a	a	DT
cord-264489-h1n9ywbd	183	11	structurally	structurally	RB
cord-264489-h1n9ywbd	183	12	steady	steady	JJ
cord-264489-h1n9ywbd	183	13	protein	protein	NN
cord-264489-h1n9ywbd	183	14	and	and	CC
cord-264489-h1n9ywbd	183	15	that	that	IN
cord-264489-h1n9ywbd	183	16	it	-PRON-	PRP
cord-264489-h1n9ywbd	183	17	can	can	MD
cord-264489-h1n9ywbd	183	18	retain	retain	VB
cord-264489-h1n9ywbd	183	19	this	this	DT
cord-264489-h1n9ywbd	183	20	stability	stability	NN
cord-264489-h1n9ywbd	183	21	over	over	IN
cord-264489-h1n9ywbd	183	22	a	a	DT
cord-264489-h1n9ywbd	183	23	relatively	relatively	RB
cord-264489-h1n9ywbd	183	24	extended	extended	JJ
cord-264489-h1n9ywbd	183	25	time	time	NN
cord-264489-h1n9ywbd	183	26	-	-	HYPH
cord-264489-h1n9ywbd	183	27	scale	scale	NN
cord-264489-h1n9ywbd	183	28	.	.	.
cord-264489-h1n9ywbd	184	1	This	this	DT
cord-264489-h1n9ywbd	184	2	observation	observation	NN
cord-264489-h1n9ywbd	184	3	points	point	VBZ
cord-264489-h1n9ywbd	184	4	at	at	IN
cord-264489-h1n9ywbd	184	5	the	the	DT
cord-264489-h1n9ywbd	184	6	potential	potential	JJ
cord-264489-h1n9ywbd	184	7	use	use	NN
cord-264489-h1n9ywbd	184	8	of	of	IN
cord-264489-h1n9ywbd	184	9	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	184	10	as	as	IN
cord-264489-h1n9ywbd	184	11	an	an	DT
cord-264489-h1n9ywbd	184	12	adjuvant	adjuvant	NN
cord-264489-h1n9ywbd	184	13	for	for	IN
cord-264489-h1n9ywbd	184	14	antibody	antibody	NN
cord-264489-h1n9ywbd	184	15	generation	generation	NN
cord-264489-h1n9ywbd	184	16	and	and	CC
cord-264489-h1n9ywbd	184	17	immune	immune	JJ
cord-264489-h1n9ywbd	184	18	enhancement	enhancement	NN
cord-264489-h1n9ywbd	184	19	,	,	,
cord-264489-h1n9ywbd	184	20	which	which	WDT
cord-264489-h1n9ywbd	184	21	,	,	,
cord-264489-h1n9ywbd	184	22	in	in	IN
cord-264489-h1n9ywbd	184	23	turn	turn	NN
cord-264489-h1n9ywbd	184	24	could	could	MD
cord-264489-h1n9ywbd	184	25	facilitate	facilitate	VB
cord-264489-h1n9ywbd	184	26	future	future	JJ
cord-264489-h1n9ywbd	184	27	strategies	strategy	NNS
cord-264489-h1n9ywbd	184	28	to	to	TO
cord-264489-h1n9ywbd	184	29	develop	develop	VB
cord-264489-h1n9ywbd	184	30	novel	novel	JJ
cord-264489-h1n9ywbd	184	31	treatments	treatment	NNS
cord-264489-h1n9ywbd	184	32	for	for	IN
cord-264489-h1n9ywbd	184	33	communicable	communicable	JJ
cord-264489-h1n9ywbd	184	34	viral	viral	JJ
cord-264489-h1n9ywbd	184	35	diseases	disease	NNS
cord-264489-h1n9ywbd	184	36	.	.	.
cord-264489-h1n9ywbd	185	1	The	the	DT
cord-264489-h1n9ywbd	185	2	computational	computational	JJ
cord-264489-h1n9ywbd	185	3	results	result	NNS
cord-264489-h1n9ywbd	185	4	presented	present	VBN
cord-264489-h1n9ywbd	185	5	in	in	IN
cord-264489-h1n9ywbd	185	6	this	this	DT
cord-264489-h1n9ywbd	185	7	work	work	NN
cord-264489-h1n9ywbd	185	8	describe	describe	VB
cord-264489-h1n9ywbd	185	9	a	a	DT
cord-264489-h1n9ywbd	185	10	set	set	NN
cord-264489-h1n9ywbd	185	11	of	of	IN
cord-264489-h1n9ywbd	185	12	residue	residue	NN
cord-264489-h1n9ywbd	185	13	-	-	HYPH
cord-264489-h1n9ywbd	185	14	level	level	NN
cord-264489-h1n9ywbd	185	15	analyses	analysis	NNS
cord-264489-h1n9ywbd	185	16	of	of	IN
cord-264489-h1n9ywbd	185	17	the	the	DT
cord-264489-h1n9ywbd	185	18	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	185	19	systems	system	NNS
cord-264489-h1n9ywbd	185	20	based	base	VBN
cord-264489-h1n9ywbd	185	21	on	on	IN
cord-264489-h1n9ywbd	185	22	their	-PRON-	PRP$
cord-264489-h1n9ywbd	185	23	published	publish	VBN
cord-264489-h1n9ywbd	185	24	structures	structure	NNS
cord-264489-h1n9ywbd	185	25	.	.	.
cord-264489-h1n9ywbd	186	1	This	this	DT
cord-264489-h1n9ywbd	186	2	investigation	investigation	NN
cord-264489-h1n9ywbd	186	3	also	also	RB
cord-264489-h1n9ywbd	186	4	explores	explore	VBZ
cord-264489-h1n9ywbd	186	5	the	the	DT
cord-264489-h1n9ywbd	186	6	PPIs	ppi	NNS
cord-264489-h1n9ywbd	186	7	between	between	IN
cord-264489-h1n9ywbd	186	8	the	the	DT
cord-264489-h1n9ywbd	186	9	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	186	10	/	/	SYM
cord-264489-h1n9ywbd	186	11	IL-18R	IL-18R	NNP
cord-264489-h1n9ywbd	186	12	and	and	CC
cord-264489-h1n9ywbd	186	13	the	the	DT
cord-264489-h1n9ywbd	186	14	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	186	15	/	/	SYM
cord-264489-h1n9ywbd	186	16	IL-18BP	IL-18BP	NNP
cord-264489-h1n9ywbd	186	17	systems	system	NNS
cord-264489-h1n9ywbd	186	18	,	,	,
cord-264489-h1n9ywbd	186	19	and	and	CC
cord-264489-h1n9ywbd	186	20	notes	note	VBZ
cord-264489-h1n9ywbd	186	21	the	the	DT
cord-264489-h1n9ywbd	186	22	relevance	relevance	NN
cord-264489-h1n9ywbd	186	23	of	of	IN
cord-264489-h1n9ywbd	186	24	the	the	DT
cord-264489-h1n9ywbd	186	25	findings	finding	NNS
cord-264489-h1n9ywbd	186	26	.	.	.
cord-264489-h1n9ywbd	187	1	The	the	DT
cord-264489-h1n9ywbd	187	2	time	time	NN
cord-264489-h1n9ywbd	187	3	-	-	HYPH
cord-264489-h1n9ywbd	187	4	based	base	VBN
cord-264489-h1n9ywbd	187	5	structural	structural	JJ
cord-264489-h1n9ywbd	187	6	stabilities	stability	NNS
cord-264489-h1n9ywbd	187	7	of	of	IN
cord-264489-h1n9ywbd	187	8	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	187	9	,	,	,
cord-264489-h1n9ywbd	187	10	in	in	IN
cord-264489-h1n9ywbd	187	11	both	both	CC
cord-264489-h1n9ywbd	187	12	its	-PRON-	PRP$
cord-264489-h1n9ywbd	187	13	apo	apo	NNP
cord-264489-h1n9ywbd	187	14	and	and	CC
cord-264489-h1n9ywbd	187	15	ligand	ligand	NNP
cord-264489-h1n9ywbd	187	16	bound	bind	VBN
cord-264489-h1n9ywbd	187	17	holo	holo	JJ
cord-264489-h1n9ywbd	187	18	forms	form	NNS
cord-264489-h1n9ywbd	187	19	have	have	VBP
cord-264489-h1n9ywbd	187	20	been	be	VBN
cord-264489-h1n9ywbd	187	21	measured	measure	VBN
cord-264489-h1n9ywbd	187	22	using	use	VBG
cord-264489-h1n9ywbd	187	23	MD	MD	NNP
cord-264489-h1n9ywbd	187	24	simulation	simulation	NN
cord-264489-h1n9ywbd	187	25	.	.	.
cord-264489-h1n9ywbd	188	1	The	the	DT
cord-264489-h1n9ywbd	188	2	results	result	NNS
cord-264489-h1n9ywbd	188	3	show	show	VBP
cord-264489-h1n9ywbd	188	4	that	that	IN
cord-264489-h1n9ywbd	188	5	,	,	,
cord-264489-h1n9ywbd	188	6	the	the	DT
cord-264489-h1n9ywbd	188	7	ligand	ligand	NN
cord-264489-h1n9ywbd	188	8	is	be	VBZ
cord-264489-h1n9ywbd	188	9	somewhat	somewhat	RB
cord-264489-h1n9ywbd	188	10	more	more	RBR
cord-264489-h1n9ywbd	188	11	stable	stable	JJ
cord-264489-h1n9ywbd	188	12	in	in	IN
cord-264489-h1n9ywbd	188	13	its	-PRON-	PRP$
cord-264489-h1n9ywbd	188	14	receptor	receptor	NN
cord-264489-h1n9ywbd	188	15	bound	bind	VBN
cord-264489-h1n9ywbd	188	16	structures	structure	NNS
cord-264489-h1n9ywbd	188	17	.	.	.
cord-264489-h1n9ywbd	189	1	The	the	DT
cord-264489-h1n9ywbd	189	2	ligand	ligand	NN
cord-264489-h1n9ywbd	189	3	bound	bind	VBD
cord-264489-h1n9ywbd	189	4	receptor	receptor	NN
cord-264489-h1n9ywbd	189	5	monomer	monomer	NN
cord-264489-h1n9ywbd	189	6	3WO3	3wo3	CD
cord-264489-h1n9ywbd	189	7	has	have	VBZ
cord-264489-h1n9ywbd	189	8	been	be	VBN
cord-264489-h1n9ywbd	189	9	found	find	VBN
cord-264489-h1n9ywbd	189	10	to	to	TO
cord-264489-h1n9ywbd	189	11	be	be	VB
cord-264489-h1n9ywbd	189	12	somewhat	somewhat	RB
cord-264489-h1n9ywbd	189	13	more	more	RBR
cord-264489-h1n9ywbd	189	14	stable	stable	JJ
cord-264489-h1n9ywbd	189	15	than	than	IN
cord-264489-h1n9ywbd	189	16	the	the	DT
cord-264489-h1n9ywbd	189	17	ligand	ligand	NN
cord-264489-h1n9ywbd	189	18	bound	bind	VBN
cord-264489-h1n9ywbd	189	19	receptor	receptor	NN
cord-264489-h1n9ywbd	189	20	dimer	dimer	NN
cord-264489-h1n9ywbd	189	21	3WO4	3wo4	CD
cord-264489-h1n9ywbd	189	22	.	.	.
cord-264489-h1n9ywbd	190	1	The	the	DT
cord-264489-h1n9ywbd	190	2	immunological	immunological	JJ
cord-264489-h1n9ywbd	190	3	significance	significance	NN
cord-264489-h1n9ywbd	190	4	of	of	IN
cord-264489-h1n9ywbd	190	5	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	190	6	signaling	signal	VBG
cord-264489-h1n9ywbd	190	7	is	be	VBZ
cord-264489-h1n9ywbd	190	8	rooted	root	VBN
cord-264489-h1n9ywbd	190	9	in	in	IN
cord-264489-h1n9ywbd	190	10	the	the	DT
cord-264489-h1n9ywbd	190	11	fact	fact	NN
cord-264489-h1n9ywbd	190	12	that	that	IN
cord-264489-h1n9ywbd	190	13	,	,	,
cord-264489-h1n9ywbd	190	14	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	190	15	is	be	VBZ
cord-264489-h1n9ywbd	190	16	related	relate	VBN
cord-264489-h1n9ywbd	190	17	to	to	IN
cord-264489-h1n9ywbd	190	18	numerous	numerous	JJ
cord-264489-h1n9ywbd	190	19	autoimmune	autoimmune	JJ
cord-264489-h1n9ywbd	190	20	and	and	CC
cord-264489-h1n9ywbd	190	21	inflammatory	inflammatory	JJ
cord-264489-h1n9ywbd	190	22	diseases	disease	NNS
cord-264489-h1n9ywbd	190	23	,	,	,
cord-264489-h1n9ywbd	190	24	and	and	CC
cord-264489-h1n9ywbd	190	25	that	that	IN
cord-264489-h1n9ywbd	190	26	the	the	DT
cord-264489-h1n9ywbd	190	27	interruption	interruption	NN
cord-264489-h1n9ywbd	190	28	of	of	IN
cord-264489-h1n9ywbd	190	29	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	190	30	/	/	SYM
cord-264489-h1n9ywbd	190	31	IL-18R	IL-18R	NNP
cord-264489-h1n9ywbd	190	32	signaling	signal	VBG
cord-264489-h1n9ywbd	190	33	cascades	cascade	NNS
cord-264489-h1n9ywbd	190	34	impact	impact	VBP
cord-264489-h1n9ywbd	190	35	the	the	DT
cord-264489-h1n9ywbd	190	36	development	development	NN
cord-264489-h1n9ywbd	190	37	of	of	IN
cord-264489-h1n9ywbd	190	38	anti	anti	JJ
cord-264489-h1n9ywbd	190	39	-	-	JJ
cord-264489-h1n9ywbd	190	40	inflammatory	inflammatory	JJ
cord-264489-h1n9ywbd	190	41	drugs	drug	NNS
cord-264489-h1n9ywbd	190	42	/	/	SYM
cord-264489-h1n9ywbd	190	43	drug	drug	NN
cord-264489-h1n9ywbd	190	44	-	-	HYPH
cord-264489-h1n9ywbd	190	45	targets	target	NNS
cord-264489-h1n9ywbd	190	46	.	.	.
cord-264489-h1n9ywbd	191	1	Additionally	additionally	RB
cord-264489-h1n9ywbd	191	2	,	,	,
cord-264489-h1n9ywbd	191	3	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	191	4	upregulates	upregulate	VBZ
cord-264489-h1n9ywbd	191	5	Fas	Fas	NNP
cord-264489-h1n9ywbd	191	6	ligand	ligand	NN
cord-264489-h1n9ywbd	191	7	and	and	CC
cord-264489-h1n9ywbd	191	8	interferon	interferon	NN
cord-264489-h1n9ywbd	191	9	gamma	gamma	NN
cord-264489-h1n9ywbd	191	10	(	(	-LRB-
cord-264489-h1n9ywbd	191	11	IFN-	IFN-	NNP
cord-264489-h1n9ywbd	191	12	)	)	-RRB-
cord-264489-h1n9ywbd	191	13	leading	lead	VBG
cord-264489-h1n9ywbd	191	14	to	to	IN
cord-264489-h1n9ywbd	191	15	the	the	DT
cord-264489-h1n9ywbd	191	16	process	process	NN
cord-264489-h1n9ywbd	192	1	J	J	NNP
cord-264489-h1n9ywbd	192	2	o	o	NN
cord-264489-h1n9ywbd	192	3	u	u	NN
cord-264489-h1n9ywbd	192	4	r	r	NN
cord-264489-h1n9ywbd	192	5	n	n	NN
cord-264489-h1n9ywbd	192	6	a	a	DT
cord-264489-h1n9ywbd	192	7	l	l	NN
cord-264489-h1n9ywbd	192	8	P	p	NN
cord-264489-h1n9ywbd	192	9	r	r	NN
cord-264489-h1n9ywbd	192	10	e	e	NN
cord-264489-h1n9ywbd	192	11	-p	-p	NN
cord-264489-h1n9ywbd	193	1	r	r	NNP
cord-264489-h1n9ywbd	193	2	o	o	NN
cord-264489-h1n9ywbd	193	3	o	o	NN
cord-264489-h1n9ywbd	193	4	f	f	NN
cord-264489-h1n9ywbd	193	5	of	of	IN
cord-264489-h1n9ywbd	193	6	apoptosis	apoptosis	NN
cord-264489-h1n9ywbd	193	7	or	or	CC
cord-264489-h1n9ywbd	193	8	cell	cell	NN
cord-264489-h1n9ywbd	193	9	death	death	NN
cord-264489-h1n9ywbd	193	10	.	.	.
cord-264489-h1n9ywbd	194	1	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	194	2	biologics	biologic	NNS
cord-264489-h1n9ywbd	194	3	may	may	MD
cord-264489-h1n9ywbd	194	4	be	be	VB
cord-264489-h1n9ywbd	194	5	relevant	relevant	JJ
cord-264489-h1n9ywbd	194	6	also	also	RB
cord-264489-h1n9ywbd	194	7	in	in	IN
cord-264489-h1n9ywbd	194	8	the	the	DT
cord-264489-h1n9ywbd	194	9	contexts	contexts	NN
cord-264489-h1n9ywbd	194	10	of	of	IN
cord-264489-h1n9ywbd	194	11	immunity	immunity	NN
cord-264489-h1n9ywbd	194	12	enhancement	enhancement	NN
cord-264489-h1n9ywbd	194	13	approaches	approach	NNS
cord-264489-h1n9ywbd	194	14	.	.	.
cord-264489-h1n9ywbd	195	1	Thus	thus	RB
cord-264489-h1n9ywbd	195	2	the	the	DT
cord-264489-h1n9ywbd	195	3	detailed	detailed	JJ
cord-264489-h1n9ywbd	195	4	identification	identification	NN
cord-264489-h1n9ywbd	195	5	of	of	IN
cord-264489-h1n9ywbd	195	6	the	the	DT
cord-264489-h1n9ywbd	195	7	ligand	ligand	NN
cord-264489-h1n9ywbd	195	8	/	/	SYM
cord-264489-h1n9ywbd	195	9	receptor	receptor	NN
cord-264489-h1n9ywbd	195	10	interfaces	interface	NNS
cord-264489-h1n9ywbd	195	11	of	of	IN
cord-264489-h1n9ywbd	195	12	this	this	DT
cord-264489-h1n9ywbd	195	13	protein	protein	NN
cord-264489-h1n9ywbd	195	14	,	,	,
cord-264489-h1n9ywbd	195	15	and	and	CC
cord-264489-h1n9ywbd	195	16	subsequent	subsequent	JJ
cord-264489-h1n9ywbd	195	17	identification	identification	NN
cord-264489-h1n9ywbd	195	18	of	of	IN
cord-264489-h1n9ywbd	195	19	targeted	target	VBN
cord-264489-h1n9ywbd	195	20	-	-	HYPH
cord-264489-h1n9ywbd	195	21	therapy	therapy	NN
cord-264489-h1n9ywbd	195	22	based	base	VBN
cord-264489-h1n9ywbd	195	23	on	on	IN
cord-264489-h1n9ywbd	195	24	computer	computer	NN
cord-264489-h1n9ywbd	195	25	modeling	modeling	NN
cord-264489-h1n9ywbd	195	26	efforts	effort	NNS
cord-264489-h1n9ywbd	195	27	,	,	,
cord-264489-h1n9ywbd	195	28	as	as	IN
cord-264489-h1n9ywbd	195	29	those	those	DT
cord-264489-h1n9ywbd	195	30	discussed	discuss	VBN
cord-264489-h1n9ywbd	195	31	in	in	IN
cord-264489-h1n9ywbd	195	32	this	this	DT
cord-264489-h1n9ywbd	195	33	paper	paper	NN
cord-264489-h1n9ywbd	195	34	,	,	,
cord-264489-h1n9ywbd	195	35	could	could	MD
cord-264489-h1n9ywbd	195	36	be	be	VB
cord-264489-h1n9ywbd	195	37	helpful	helpful	JJ
cord-264489-h1n9ywbd	195	38	in	in	IN
cord-264489-h1n9ywbd	195	39	the	the	DT
cord-264489-h1n9ywbd	195	40	development	development	NN
cord-264489-h1n9ywbd	195	41	of	of	IN
cord-264489-h1n9ywbd	195	42	predictive	predictive	JJ
cord-264489-h1n9ywbd	195	43	immunotherapy	immunotherapy	NN
cord-264489-h1n9ywbd	195	44	and	and	CC
cord-264489-h1n9ywbd	195	45	precision	precision	NNP
cord-264489-h1n9ywbd	195	46	bio	bio	NN
cord-264489-h1n9ywbd	195	47	-	-	HYPH
cord-264489-h1n9ywbd	195	48	therapeutics	therapeutic	NNS
cord-264489-h1n9ywbd	195	49	.	.	.
cord-264489-h1n9ywbd	196	1	The	the	DT
cord-264489-h1n9ywbd	196	2	author	author	NN
cord-264489-h1n9ywbd	196	3	has	have	VBZ
cord-264489-h1n9ywbd	196	4	attached	attach	VBN
cord-264489-h1n9ywbd	196	5	all	all	DT
cord-264489-h1n9ywbd	196	6	high	high	JJ
cord-264489-h1n9ywbd	196	7	resolution	resolution	NN
cord-264489-h1n9ywbd	196	8	figures	figure	NNS
cord-264489-h1n9ywbd	196	9	(	(	-LRB-
cord-264489-h1n9ywbd	196	10	Figs	fig	NNS
cord-264489-h1n9ywbd	196	11	1	1	CD
cord-264489-h1n9ywbd	196	12	to	to	IN
cord-264489-h1n9ywbd	196	13	9	9	CD
cord-264489-h1n9ywbd	196	14	and	and	CC
cord-264489-h1n9ywbd	196	15	graphical	graphical	JJ
cord-264489-h1n9ywbd	196	16	abstract	abstract	NN
cord-264489-h1n9ywbd	196	17	)	)	-RRB-
cord-264489-h1n9ywbd	196	18	as	as	IN
cord-264489-h1n9ywbd	196	19	Zip	zip	NN
cord-264489-h1n9ywbd	196	20	files	file	NNS
cord-264489-h1n9ywbd	196	21	.	.	.
cord-264489-h1n9ywbd	197	1	This	this	DT
cord-264489-h1n9ywbd	197	2	research	research	NN
cord-264489-h1n9ywbd	197	3	did	do	VBD
cord-264489-h1n9ywbd	197	4	not	not	RB
cord-264489-h1n9ywbd	197	5	receive	receive	VB
cord-264489-h1n9ywbd	197	6	any	any	DT
cord-264489-h1n9ywbd	197	7	specific	specific	JJ
cord-264489-h1n9ywbd	197	8	grant	grant	NN
cord-264489-h1n9ywbd	197	9	from	from	IN
cord-264489-h1n9ywbd	197	10	funding	fund	VBG
cord-264489-h1n9ywbd	197	11	agencies	agency	NNS
cord-264489-h1n9ywbd	197	12	in	in	IN
cord-264489-h1n9ywbd	197	13	the	the	DT
cord-264489-h1n9ywbd	197	14	public	public	NN
cord-264489-h1n9ywbd	197	15	,	,	,
cord-264489-h1n9ywbd	197	16	commercial	commercial	JJ
cord-264489-h1n9ywbd	197	17	,	,	,
cord-264489-h1n9ywbd	197	18	or	or	CC
cord-264489-h1n9ywbd	197	19	not	not	RB
cord-264489-h1n9ywbd	197	20	-	-	HYPH
cord-264489-h1n9ywbd	197	21	for	for	IN
cord-264489-h1n9ywbd	197	22	-	-	HYPH
cord-264489-h1n9ywbd	197	23	profit	profit	NN
cord-264489-h1n9ywbd	197	24	sectors	sector	NNS
cord-264489-h1n9ywbd	197	25	.	.	.
cord-264489-h1n9ywbd	198	1	The	the	DT
cord-264489-h1n9ywbd	198	2	author	author	NN
cord-264489-h1n9ywbd	198	3	declares	declare	VBZ
cord-264489-h1n9ywbd	198	4	no	no	DT
cord-264489-h1n9ywbd	198	5	conflict	conflict	NN
cord-264489-h1n9ywbd	198	6	of	of	IN
cord-264489-h1n9ywbd	198	7	interest	interest	NN
cord-264489-h1n9ywbd	198	8	.	.	.
cord-264489-h1n9ywbd	199	1	(	(	-LRB-
cord-264489-h1n9ywbd	199	2	residues	residue	NNS
cord-264489-h1n9ywbd	199	3	35	35	CD
cord-264489-h1n9ywbd	199	4	-	-	SYM
cord-264489-h1n9ywbd	199	5	40	40	CD
cord-264489-h1n9ywbd	199	6	)	)	-RRB-
cord-264489-h1n9ywbd	199	7	that	that	WDT
cord-264489-h1n9ywbd	199	8	turned	turn	VBD
cord-264489-h1n9ywbd	199	9	into	into	IN
cord-264489-h1n9ywbd	199	10	a	a	DT
cord-264489-h1n9ywbd	199	11	helical	helical	JJ
cord-264489-h1n9ywbd	199	12	structure	structure	NN
cord-264489-h1n9ywbd	199	13	has	have	VBZ
cord-264489-h1n9ywbd	199	14	been	be	VBN
cord-264489-h1n9ywbd	199	15	shown	show	VBN
cord-264489-h1n9ywbd	199	16	in	in	IN
cord-264489-h1n9ywbd	199	17	a	a	DT
cord-264489-h1n9ywbd	199	18	different	different	JJ
cord-264489-h1n9ywbd	199	19	color	color	NN
cord-264489-h1n9ywbd	199	20	,	,	,
cord-264489-h1n9ywbd	199	21	grey	grey	NNP
cord-264489-h1n9ywbd	199	22	.	.	.
cord-264489-h1n9ywbd	200	1	E.	E.	NNP
cord-264489-h1n9ywbd	200	2	highlight	highlight	VBP
cord-264489-h1n9ywbd	200	3	the	the	DT
cord-264489-h1n9ywbd	200	4	main	main	JJ
cord-264489-h1n9ywbd	200	5	interacting	interact	VBG
cord-264489-h1n9ywbd	200	6	residues	residue	NNS
cord-264489-h1n9ywbd	200	7	,	,	,
cord-264489-h1n9ywbd	200	8	the	the	DT
cord-264489-h1n9ywbd	200	9	secondary	secondary	JJ
cord-264489-h1n9ywbd	200	10	structures	structure	NNS
cord-264489-h1n9ywbd	200	11	in	in	IN
cord-264489-h1n9ywbd	200	12	Fig	Fig	NNP
cord-264489-h1n9ywbd	200	13	.	.	.
cord-264489-h1n9ywbd	201	1	4	4	CD
cord-264489-h1n9ywbd	201	2	have	have	VBP
cord-264489-h1n9ywbd	201	3	been	be	VBN
cord-264489-h1n9ywbd	201	4	are	be	VBP
cord-264489-h1n9ywbd	201	5	presented	present	VBN
cord-264489-h1n9ywbd	201	6	in	in	IN
cord-264489-h1n9ywbd	201	7	the	the	DT
cord-264489-h1n9ywbd	201	8	line	line	NN
cord-264489-h1n9ywbd	201	9	diagrams	diagram	NNS
cord-264489-h1n9ywbd	201	10	.	.	.
cord-264489-h1n9ywbd	201	11	 	 	_SP
cord-264489-h1n9ywbd	202	1	Genome3D	Genome3D	NNP
cord-264489-h1n9ywbd	202	2	:	:	:
cord-264489-h1n9ywbd	203	1	a	a	DT
cord-264489-h1n9ywbd	203	2	viewer	viewer	NN
cord-264489-h1n9ywbd	203	3	-	-	HYPH
cord-264489-h1n9ywbd	203	4	model	model	NN
cord-264489-h1n9ywbd	203	5	framework	framework	NN
cord-264489-h1n9ywbd	203	6	for	for	IN
cord-264489-h1n9ywbd	203	7	integrating	integrate	VBG
cord-264489-h1n9ywbd	203	8	and	and	CC
cord-264489-h1n9ywbd	203	9	visualizing	visualize	VBG
cord-264489-h1n9ywbd	203	10	multi	multi	JJ
cord-264489-h1n9ywbd	203	11	-	-	JJ
cord-264489-h1n9ywbd	203	12	scale	scale	JJ
cord-264489-h1n9ywbd	203	13	epigenomic	epigenomic	JJ
cord-264489-h1n9ywbd	203	14	information	information	NN
cord-264489-h1n9ywbd	203	15	within	within	IN
cord-264489-h1n9ywbd	203	16	a	a	DT
cord-264489-h1n9ywbd	203	17	three	three	CD
cord-264489-h1n9ywbd	203	18	-	-	HYPH
cord-264489-h1n9ywbd	203	19	dimensional	dimensional	JJ
cord-264489-h1n9ywbd	203	20	genome	genome	NN
cord-264489-h1n9ywbd	204	1	The	the	DT
cord-264489-h1n9ywbd	204	2	protein	protein	NN
cord-264489-h1n9ywbd	204	3	data	datum	NNS
cord-264489-h1n9ywbd	204	4	bank	bank	NN
cord-264489-h1n9ywbd	205	1	An	an	DT
cord-264489-h1n9ywbd	205	2	up	up	JJ
cord-264489-h1n9ywbd	205	3	-	-	HYPH
cord-264489-h1n9ywbd	205	4	to	to	IN
cord-264489-h1n9ywbd	205	5	-	-	HYPH
cord-264489-h1n9ywbd	205	6	date	date	NN
cord-264489-h1n9ywbd	205	7	review	review	NN
cord-264489-h1n9ywbd	205	8	of	of	IN
cord-264489-h1n9ywbd	205	9	piglet	piglet	NNP
cord-264489-h1n9ywbd	205	10	isosporosis	isosporosis	NNP
cord-264489-h1n9ywbd	205	11	:	:	:
cord-264489-h1n9ywbd	205	12	new	new	JJ
cord-264489-h1n9ywbd	205	13	insights	insight	NNS
cord-264489-h1n9ywbd	205	14	and	and	CC
cord-264489-h1n9ywbd	205	15	therapeutic	therapeutic	JJ
cord-264489-h1n9ywbd	205	16	perspectives	perspective	NNS
cord-264489-h1n9ywbd	205	17	Cytokines	Cytokines	NNPS
cord-264489-h1n9ywbd	205	18	as	as	IN
cord-264489-h1n9ywbd	205	19	adjuvants	adjuvant	NNS
cord-264489-h1n9ywbd	205	20	for	for	IN
cord-264489-h1n9ywbd	205	21	the	the	DT
cord-264489-h1n9ywbd	205	22	induction	induction	NN
cord-264489-h1n9ywbd	205	23	of	of	IN
cord-264489-h1n9ywbd	205	24	anti	anti	JJ
cord-264489-h1n9ywbd	205	25	-	-	JJ
cord-264489-h1n9ywbd	205	26	human	human	JJ
cord-264489-h1n9ywbd	205	27	immunodeficiency	immunodeficiency	NN
cord-264489-h1n9ywbd	205	28	virus	virus	NN
cord-264489-h1n9ywbd	205	29	peptide	peptide	NN
cord-264489-h1n9ywbd	205	30	immunoglobulin	immunoglobulin	NN
cord-264489-h1n9ywbd	205	31	G	G	NNP
cord-264489-h1n9ywbd	205	32	(	(	-LRB-
cord-264489-h1n9ywbd	205	33	IgG	IgG	NNP
cord-264489-h1n9ywbd	205	34	)	)	-RRB-
cord-264489-h1n9ywbd	205	35	and	and	CC
cord-264489-h1n9ywbd	205	36	IgA	IgA	NNP
cord-264489-h1n9ywbd	205	37	antibodies	antibody	NNS
cord-264489-h1n9ywbd	205	38	in	in	IN
cord-264489-h1n9ywbd	205	39	serum	serum	NN
cord-264489-h1n9ywbd	205	40	and	and	CC
cord-264489-h1n9ywbd	205	41	mucosal	mucosal	JJ
cord-264489-h1n9ywbd	205	42	secretions	secretion	NNS
cord-264489-h1n9ywbd	205	43	after	after	IN
cord-264489-h1n9ywbd	205	44	nasal	nasal	NN
cord-264489-h1n9ywbd	205	45	immunization	immunization	NN
cord-264489-h1n9ywbd	205	46	mentha	mentha	NN
cord-264489-h1n9ywbd	205	47	:	:	:
cord-264489-h1n9ywbd	205	48	a	a	DT
cord-264489-h1n9ywbd	205	49	resource	resource	NN
cord-264489-h1n9ywbd	205	50	for	for	IN
cord-264489-h1n9ywbd	205	51	browsing	browse	VBG
cord-264489-h1n9ywbd	205	52	integrated	integrate	VBN
cord-264489-h1n9ywbd	205	53	proteininteraction	proteininteraction	NN
cord-264489-h1n9ywbd	205	54	networks	network	NNS
cord-264489-h1n9ywbd	206	1	Technetium-99	technetium-99	NN
cord-264489-h1n9ywbd	206	2	m	m	CD
cord-264489-h1n9ywbd	206	3	cysteine	cysteine	NN
cord-264489-h1n9ywbd	206	4	;	;	:
cord-264489-h1n9ywbd	206	5	a	a	DT
cord-264489-h1n9ywbd	206	6	novel	novel	JJ
cord-264489-h1n9ywbd	206	7	radiopharmaceutical	radiopharmaceutical	NN
cord-264489-h1n9ywbd	206	8	for	for	IN
cord-264489-h1n9ywbd	206	9	detection	detection	NN
cord-264489-h1n9ywbd	206	10	of	of	IN
cord-264489-h1n9ywbd	206	11	experimental	experimental	JJ
cord-264489-h1n9ywbd	206	12	myocardial	myocardial	JJ
cord-264489-h1n9ywbd	206	13	infarction	infarction	NN
cord-264489-h1n9ywbd	206	14	in	in	IN
cord-264489-h1n9ywbd	206	15	rats	rat	NNS
cord-264489-h1n9ywbd	206	16	CoMFA	CoMFA	NNP
cord-264489-h1n9ywbd	206	17	,	,	,
cord-264489-h1n9ywbd	207	1	CoMSIA	CoMSIA	NNP
cord-264489-h1n9ywbd	207	2	,	,	,
cord-264489-h1n9ywbd	207	3	Topomer	Topomer	NNP
cord-264489-h1n9ywbd	207	4	CoMFA	CoMFA	NNP
cord-264489-h1n9ywbd	207	5	,	,	,
cord-264489-h1n9ywbd	207	6	HQSAR	HQSAR	NNP
cord-264489-h1n9ywbd	207	7	,	,	,
cord-264489-h1n9ywbd	207	8	molecular	molecular	JJ
cord-264489-h1n9ywbd	207	9	docking	docking	NN
cord-264489-h1n9ywbd	207	10	and	and	CC
cord-264489-h1n9ywbd	207	11	molecular	molecular	JJ
cord-264489-h1n9ywbd	207	12	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	207	13	simulations	simulation	NNS
cord-264489-h1n9ywbd	207	14	study	study	NN
cord-264489-h1n9ywbd	207	15	of	of	IN
cord-264489-h1n9ywbd	207	16	triazine	triazine	NNP
cord-264489-h1n9ywbd	207	17	morpholino	morpholino	NNP
cord-264489-h1n9ywbd	207	18	derivatives	derivative	NNS
cord-264489-h1n9ywbd	207	19	as	as	IN
cord-264489-h1n9ywbd	207	20	mTOR	mTOR	NNP
cord-264489-h1n9ywbd	207	21	inhibitors	inhibitor	NNS
cord-264489-h1n9ywbd	207	22	for	for	IN
cord-264489-h1n9ywbd	207	23	the	the	DT
cord-264489-h1n9ywbd	207	24	treatment	treatment	NN
cord-264489-h1n9ywbd	207	25	of	of	IN
cord-264489-h1n9ywbd	207	26	breast	breast	NN
cord-264489-h1n9ywbd	207	27	cancer	cancer	NN
cord-264489-h1n9ywbd	207	28	Discovery	Discovery	NNP
cord-264489-h1n9ywbd	207	29	Studio	Studio	NNP
cord-264489-h1n9ywbd	207	30	Modeling	Modeling	NNP
cord-264489-h1n9ywbd	207	31	Environment	Environment	NNP
cord-264489-h1n9ywbd	207	32	Comparative	Comparative	NNP
cord-264489-h1n9ywbd	207	33	antiradical	antiradical	JJ
cord-264489-h1n9ywbd	207	34	activity	activity	NN
cord-264489-h1n9ywbd	207	35	and	and	CC
cord-264489-h1n9ywbd	207	36	molecular	molecular	JJ
cord-264489-h1n9ywbd	207	37	Docking	Docking	NNP
cord-264489-h1n9ywbd	207	38	/	/	SYM
cord-264489-h1n9ywbd	207	39	Dynamics	Dynamics	NNP
cord-264489-h1n9ywbd	207	40	analysis	analysis	NN
cord-264489-h1n9ywbd	207	41	of	of	IN
cord-264489-h1n9ywbd	207	42	octopamine	octopamine	NN
cord-264489-h1n9ywbd	207	43	and	and	CC
cord-264489-h1n9ywbd	207	44	norepinephrine	norepinephrine	NN
cord-264489-h1n9ywbd	207	45	:	:	:
cord-264489-h1n9ywbd	208	1	the	the	DT
cord-264489-h1n9ywbd	208	2	role	role	NN
cord-264489-h1n9ywbd	208	3	of	of	IN
cord-264489-h1n9ywbd	208	4	OH	OH	NNP
cord-264489-h1n9ywbd	208	5	groups	group	NNS
cord-264489-h1n9ywbd	208	6	Interleukin-18	interleukin-18	NN
cord-264489-h1n9ywbd	208	7	and	and	CC
cord-264489-h1n9ywbd	208	8	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	208	9	binding	bind	VBG
cord-264489-h1n9ywbd	208	10	protein	protein	NN
cord-264489-h1n9ywbd	208	11	.	.	.
cord-264489-h1n9ywbd	209	1	Front	front	JJ
cord-264489-h1n9ywbd	209	2	Interleukin-18	interleukin-18	NN
cord-264489-h1n9ywbd	209	3	A	a	DT
cord-264489-h1n9ywbd	209	4	hypergraph	hypergraph	NN
cord-264489-h1n9ywbd	209	5	-	-	HYPH
cord-264489-h1n9ywbd	209	6	based	base	VBN
cord-264489-h1n9ywbd	209	7	method	method	NN
cord-264489-h1n9ywbd	209	8	for	for	IN
cord-264489-h1n9ywbd	209	9	unification	unification	NN
cord-264489-h1n9ywbd	209	10	of	of	IN
cord-264489-h1n9ywbd	209	11	existing	exist	VBG
cord-264489-h1n9ywbd	209	12	protein	protein	NN
cord-264489-h1n9ywbd	209	13	structure	structure	NN
cord-264489-h1n9ywbd	209	14	-	-	:
cord-264489-h1n9ywbd	209	15	and	and	CC
cord-264489-h1n9ywbd	209	16	sequence	sequence	NN
cord-264489-h1n9ywbd	209	17	-	-	HYPH
cord-264489-h1n9ywbd	209	18	families	family	NNS
cord-264489-h1n9ywbd	209	19	Cation	Cation	NNP
cord-264489-h1n9ywbd	209	20	-	-	HYPH
cord-264489-h1n9ywbd	209	21	π	π	NNP
cord-264489-h1n9ywbd	209	22	interactions	interaction	NNS
cord-264489-h1n9ywbd	209	23	in	in	IN
cord-264489-h1n9ywbd	209	24	structural	structural	JJ
cord-264489-h1n9ywbd	209	25	biology	biology	NN
cord-264489-h1n9ywbd	209	26	Conserved	conserve	VBN
cord-264489-h1n9ywbd	209	27	molecular	molecular	JJ
cord-264489-h1n9ywbd	209	28	signatures	signature	NNS
cord-264489-h1n9ywbd	209	29	in	in	IN
cord-264489-h1n9ywbd	209	30	gp120	gp120	NNP
cord-264489-h1n9ywbd	209	31	are	be	VBP
cord-264489-h1n9ywbd	209	32	associated	associate	VBN
cord-264489-h1n9ywbd	209	33	with	with	IN
cord-264489-h1n9ywbd	209	34	the	the	DT
cord-264489-h1n9ywbd	209	35	genetic	genetic	JJ
cord-264489-h1n9ywbd	209	36	bottleneck	bottleneck	NN
cord-264489-h1n9ywbd	209	37	during	during	IN
cord-264489-h1n9ywbd	209	38	simian	simian	JJ
cord-264489-h1n9ywbd	209	39	immunodeficiency	immunodeficiency	NN
cord-264489-h1n9ywbd	209	40	virus	virus	NN
cord-264489-h1n9ywbd	209	41	(	(	-LRB-
cord-264489-h1n9ywbd	209	42	SIV	SIV	NNP
cord-264489-h1n9ywbd	209	43	)	)	-RRB-
cord-264489-h1n9ywbd	209	44	,	,	,
cord-264489-h1n9ywbd	209	45	SIVhuman	SIVhuman	NNP
cord-264489-h1n9ywbd	209	46	immunodeficiency	immunodeficiency	NN
cord-264489-h1n9ywbd	209	47	virus	virus	NN
cord-264489-h1n9ywbd	209	48	(	(	-LRB-
cord-264489-h1n9ywbd	209	49	SHIV	SHIV	NNP
cord-264489-h1n9ywbd	209	50	)	)	-RRB-
cord-264489-h1n9ywbd	209	51	,	,	,
cord-264489-h1n9ywbd	209	52	and	and	CC
cord-264489-h1n9ywbd	209	53	HIV	HIV	NNP
cord-264489-h1n9ywbd	209	54	type	type	NN
cord-264489-h1n9ywbd	209	55	1	1	CD
cord-264489-h1n9ywbd	209	56	(	(	-LRB-
cord-264489-h1n9ywbd	209	57	HIV-1	HIV-1	NNP
cord-264489-h1n9ywbd	209	58	)	)	-RRB-
cord-264489-h1n9ywbd	209	59	transmission	transmission	NN
cord-264489-h1n9ywbd	210	1	Interleukin-18	Interleukin-18	NNP
cord-264489-h1n9ywbd	210	2	SWISS	swiss	JJ
cord-264489-h1n9ywbd	210	3	-	-	HYPH
cord-264489-h1n9ywbd	210	4	MODEL	model	NN
cord-264489-h1n9ywbd	210	5	and	and	CC
cord-264489-h1n9ywbd	210	6	the	the	DT
cord-264489-h1n9ywbd	210	7	Swiss	Swiss	NNP
cord-264489-h1n9ywbd	210	8	-	-	HYPH
cord-264489-h1n9ywbd	210	9	PdbViewer	PdbViewer	NNP
cord-264489-h1n9ywbd	210	10	:	:	:
cord-264489-h1n9ywbd	211	1	an	an	DT
cord-264489-h1n9ywbd	211	2	environment	environment	NN
cord-264489-h1n9ywbd	211	3	for	for	IN
cord-264489-h1n9ywbd	211	4	comparative	comparative	JJ
cord-264489-h1n9ywbd	211	5	protein	protein	NN
cord-264489-h1n9ywbd	211	6	modeling	modeling	NN
cord-264489-h1n9ywbd	211	7	Mechanism	mechanism	NN
cord-264489-h1n9ywbd	211	8	for	for	IN
cord-264489-h1n9ywbd	211	9	IL-15-driven	IL-15-driven	NNP
cord-264489-h1n9ywbd	211	10	B	b	NN
cord-264489-h1n9ywbd	211	11	cell	cell	NN
cord-264489-h1n9ywbd	211	12	chronic	chronic	NN
cord-264489-h1n9ywbd	211	13	lymphocytic	lymphocytic	JJ
cord-264489-h1n9ywbd	211	14	leukemia	leukemia	NN
cord-264489-h1n9ywbd	211	15	cycling	cycling	NN
cord-264489-h1n9ywbd	211	16	:	:	:
cord-264489-h1n9ywbd	211	17	roles	role	NNS
cord-264489-h1n9ywbd	211	18	for	for	IN
cord-264489-h1n9ywbd	211	19	AKT	AKT	NNP
cord-264489-h1n9ywbd	211	20	and	and	CC
cord-264489-h1n9ywbd	211	21	STAT5	stat5	NN
cord-264489-h1n9ywbd	211	22	in	in	IN
cord-264489-h1n9ywbd	211	23	modulating	modulate	VBG
cord-264489-h1n9ywbd	211	24	cyclin	cyclin	NN
cord-264489-h1n9ywbd	211	25	D2	d2	NN
cord-264489-h1n9ywbd	211	26	and	and	CC
cord-264489-h1n9ywbd	211	27	DNA	dna	NN
cord-264489-h1n9ywbd	211	28	damage	damage	NN
cord-264489-h1n9ywbd	211	29	response	response	NN
cord-264489-h1n9ywbd	211	30	proteins	protein	NNS
cord-264489-h1n9ywbd	211	31	Human	human	JJ
cord-264489-h1n9ywbd	211	32	anti	anti	JJ
cord-264489-h1n9ywbd	211	33	-	-	JJ
cord-264489-h1n9ywbd	211	34	human	human	JJ
cord-264489-h1n9ywbd	211	35	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	211	36	antibody	antibody	NN
cord-264489-h1n9ywbd	211	37	recognizing	recognize	VBG
cord-264489-h1n9ywbd	211	38	the	the	DT
cord-264489-h1n9ywbd	211	39	IL-18-binding	il-18-binde	VBG
cord-264489-h1n9ywbd	211	40	site	site	NN
cord-264489-h1n9ywbd	211	41	3	3	CD
cord-264489-h1n9ywbd	211	42	with	with	IN
cord-264489-h1n9ywbd	211	43	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	211	44	signaling	signal	VBG
cord-264489-h1n9ywbd	211	45	blocking	block	VBG
cord-264489-h1n9ywbd	211	46	activity	activity	NN
cord-264489-h1n9ywbd	211	47	BioASF	BioASF	NNP
cord-264489-h1n9ywbd	211	48	:	:	:
cord-264489-h1n9ywbd	211	49	a	a	DT
cord-264489-h1n9ywbd	211	50	framework	framework	NN
cord-264489-h1n9ywbd	211	51	for	for	IN
cord-264489-h1n9ywbd	211	52	automatically	automatically	RB
cord-264489-h1n9ywbd	211	53	generating	generate	VBG
cord-264489-h1n9ywbd	211	54	executable	executable	JJ
cord-264489-h1n9ywbd	211	55	pathway	pathway	NN
cord-264489-h1n9ywbd	211	56	models	model	NNS
cord-264489-h1n9ywbd	211	57	specified	specify	VBN
cord-264489-h1n9ywbd	211	58	in	in	IN
cord-264489-h1n9ywbd	211	59	BioPAX	biopax	JJ
cord-264489-h1n9ywbd	211	60	Amino	amino	NN
cord-264489-h1n9ywbd	211	61	acid	acid	NN
cord-264489-h1n9ywbd	211	62	substitution	substitution	NN
cord-264489-h1n9ywbd	211	63	matrices	matrix	NNS
cord-264489-h1n9ywbd	211	64	from	from	IN
cord-264489-h1n9ywbd	211	65	protein	protein	NN
cord-264489-h1n9ywbd	211	66	blocks	block	NNS
cord-264489-h1n9ywbd	212	1	Combinatorial	combinatorial	JJ
cord-264489-h1n9ywbd	212	2	coarse	coarse	NN
cord-264489-h1n9ywbd	212	3	-	-	HYPH
cord-264489-h1n9ywbd	212	4	graining	graining	NN
cord-264489-h1n9ywbd	212	5	of	of	IN
cord-264489-h1n9ywbd	212	6	molecular	molecular	JJ
cord-264489-h1n9ywbd	212	7	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	212	8	simulations	simulation	NNS
cord-264489-h1n9ywbd	212	9	for	for	IN
cord-264489-h1n9ywbd	212	10	detecting	detect	VBG
cord-264489-h1n9ywbd	212	11	relationships	relationship	NNS
cord-264489-h1n9ywbd	212	12	between	between	IN
cord-264489-h1n9ywbd	212	13	local	local	JJ
cord-264489-h1n9ywbd	212	14	configurations	configuration	NNS
cord-264489-h1n9ywbd	212	15	and	and	CC
cord-264489-h1n9ywbd	212	16	overall	overall	JJ
cord-264489-h1n9ywbd	212	17	conformations	conformation	NNS
cord-264489-h1n9ywbd	212	18	Docking	dock	VBG
cord-264489-h1n9ywbd	212	19	simulation	simulation	NN
cord-264489-h1n9ywbd	212	20	and	and	CC
cord-264489-h1n9ywbd	212	21	antibiotic	antibiotic	JJ
cord-264489-h1n9ywbd	212	22	discovery	discovery	NN
cord-264489-h1n9ywbd	212	23	targeting	target	VBG
cord-264489-h1n9ywbd	212	24	the	the	DT
cord-264489-h1n9ywbd	212	25	MlaC	MlaC	NNP
cord-264489-h1n9ywbd	212	26	protein	protein	NN
cord-264489-h1n9ywbd	212	27	in	in	IN
cord-264489-h1n9ywbd	212	28	Gram	gram	NN
cord-264489-h1n9ywbd	212	29	-	-	HYPH
cord-264489-h1n9ywbd	212	30	negative	negative	JJ
cord-264489-h1n9ywbd	212	31	bacteria	bacteria	NNS
cord-264489-h1n9ywbd	212	32	VMD	VMD	NNP
cord-264489-h1n9ywbd	212	33	:	:	:
cord-264489-h1n9ywbd	213	1	Visual	visual	JJ
cord-264489-h1n9ywbd	213	2	molecular	molecular	JJ
cord-264489-h1n9ywbd	213	3	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	214	1	The	the	DT
cord-264489-h1n9ywbd	214	2	structural	structural	JJ
cord-264489-h1n9ywbd	214	3	basis	basis	NN
cord-264489-h1n9ywbd	214	4	of	of	IN
cord-264489-h1n9ywbd	214	5	the	the	DT
cord-264489-h1n9ywbd	214	6	farnesylated	farnesylate	VBN
cord-264489-h1n9ywbd	214	7	and	and	CC
cord-264489-h1n9ywbd	214	8	methylated	methylate	VBN
cord-264489-h1n9ywbd	214	9	KRas4B	KRas4B	NNP
cord-264489-h1n9ywbd	214	10	interaction	interaction	NN
cord-264489-h1n9ywbd	214	11	with	with	IN
cord-264489-h1n9ywbd	214	12	calmodulin	calmodulin	NN
cord-264489-h1n9ywbd	214	13	On	on	IN
cord-264489-h1n9ywbd	214	14	the	the	DT
cord-264489-h1n9ywbd	214	15	origin	origin	NN
cord-264489-h1n9ywbd	214	16	of	of	IN
cord-264489-h1n9ywbd	214	17	biomolecular	biomolecular	JJ
cord-264489-h1n9ywbd	214	18	networks	network	NNS
cord-264489-h1n9ywbd	214	19	Essential	essential	JJ
cord-264489-h1n9ywbd	214	20	protein	protein	NN
cord-264489-h1n9ywbd	214	21	identification	identification	NN
cord-264489-h1n9ywbd	214	22	based	base	VBN
cord-264489-h1n9ywbd	214	23	on	on	IN
cord-264489-h1n9ywbd	214	24	essential	essential	JJ
cord-264489-h1n9ywbd	214	25	protein	protein	NN
cord-264489-h1n9ywbd	214	26	-	-	HYPH
cord-264489-h1n9ywbd	214	27	protein	protein	NN
cord-264489-h1n9ywbd	214	28	interaction	interaction	NN
cord-264489-h1n9ywbd	214	29	prediction	prediction	NN
cord-264489-h1n9ywbd	214	30	by	by	IN
cord-264489-h1n9ywbd	214	31	Integrated	Integrated	NNP
cord-264489-h1n9ywbd	214	32	Edge	Edge	NNP
cord-264489-h1n9ywbd	214	33	Weights	Weights	NNP
cord-264489-h1n9ywbd	214	34	Structure	Structure	NNP
cord-264489-h1n9ywbd	214	35	-	-	HYPH
cord-264489-h1n9ywbd	214	36	based	base	VBN
cord-264489-h1n9ywbd	214	37	virtual	virtual	JJ
cord-264489-h1n9ywbd	214	38	screening	screening	NN
cord-264489-h1n9ywbd	214	39	of	of	IN
cord-264489-h1n9ywbd	214	40	influenza	influenza	NN
cord-264489-h1n9ywbd	214	41	virus	virus	NN
cord-264489-h1n9ywbd	214	42	RNA	RNA	NNP
cord-264489-h1n9ywbd	214	43	polymerase	polymerase	NN
cord-264489-h1n9ywbd	214	44	inhibitors	inhibitor	NNS
cord-264489-h1n9ywbd	214	45	from	from	IN
cord-264489-h1n9ywbd	214	46	natural	natural	JJ
cord-264489-h1n9ywbd	214	47	compounds	compound	NNS
cord-264489-h1n9ywbd	214	48	:	:	:
cord-264489-h1n9ywbd	214	49	Molecular	molecular	JJ
cord-264489-h1n9ywbd	214	50	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	214	51	simulation	simulation	NN
cord-264489-h1n9ywbd	214	52	and	and	CC
cord-264489-h1n9ywbd	214	53	MM	MM	NNP
cord-264489-h1n9ywbd	214	54	-	-	HYPH
cord-264489-h1n9ywbd	214	55	GBSA	GBSA	NNP
cord-264489-h1n9ywbd	214	56	calculation	calculation	NN
cord-264489-h1n9ywbd	214	57	Structural	structural	JJ
cord-264489-h1n9ywbd	214	58	Concepts	Concepts	NNPS
cord-264489-h1n9ywbd	214	59	in	in	IN
cord-264489-h1n9ywbd	214	60	Immunology	Immunology	NNP
cord-264489-h1n9ywbd	214	61	and	and	CC
cord-264489-h1n9ywbd	214	62	Immunochemistry	Immunochemistry	NNP
cord-264489-h1n9ywbd	214	63	.	.	.
cord-264489-h1n9ywbd	215	1	Holt	Holt	NNP
cord-264489-h1n9ywbd	216	1	The	the	DT
cord-264489-h1n9ywbd	216	2	structure	structure	NN
cord-264489-h1n9ywbd	216	3	and	and	CC
cord-264489-h1n9ywbd	216	4	binding	binding	NN
cord-264489-h1n9ywbd	216	5	mode	mode	NN
cord-264489-h1n9ywbd	216	6	of	of	IN
cord-264489-h1n9ywbd	216	7	interleukin-18	interleukin-18	NNP
cord-264489-h1n9ywbd	216	8	Expression	Expression	NNP
cord-264489-h1n9ywbd	216	9	,	,	,
cord-264489-h1n9ywbd	216	10	purification	purification	NN
cord-264489-h1n9ywbd	216	11	and	and	CC
cord-264489-h1n9ywbd	216	12	structural	structural	JJ
cord-264489-h1n9ywbd	216	13	analysis	analysis	NN
cord-264489-h1n9ywbd	216	14	of	of	IN
cord-264489-h1n9ywbd	216	15	human	human	JJ
cord-264489-h1n9ywbd	216	16	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	216	17	binding	bind	VBG
cord-264489-h1n9ywbd	216	18	protein	protein	NN
cord-264489-h1n9ywbd	216	19	:	:	:
cord-264489-h1n9ywbd	216	20	a	a	DT
cord-264489-h1n9ywbd	216	21	potent	potent	JJ
cord-264489-h1n9ywbd	216	22	therapeutic	therapeutic	JJ
cord-264489-h1n9ywbd	216	23	molecule	molecule	NN
cord-264489-h1n9ywbd	216	24	for	for	IN
cord-264489-h1n9ywbd	216	25	allergy	allergy	NN
cord-264489-h1n9ywbd	216	26	Structural	structural	JJ
cord-264489-h1n9ywbd	216	27	basis	basis	NN
cord-264489-h1n9ywbd	216	28	for	for	IN
cord-264489-h1n9ywbd	216	29	antagonism	antagonism	NN
cord-264489-h1n9ywbd	216	30	of	of	IN
cord-264489-h1n9ywbd	216	31	human	human	JJ
cord-264489-h1n9ywbd	216	32	interleukin	interleukin	NN
cord-264489-h1n9ywbd	216	33	18	18	CD
cord-264489-h1n9ywbd	216	34	by	by	IN
cord-264489-h1n9ywbd	216	35	poxvirus	poxvirus	NNP
cord-264489-h1n9ywbd	216	36	interleukin	interleukin	NNP
cord-264489-h1n9ywbd	216	37	18-binding	18-binding	CD
cord-264489-h1n9ywbd	216	38	protein	protein	NN
cord-264489-h1n9ywbd	217	1	MEGA7	MEGA7	NNP
cord-264489-h1n9ywbd	217	2	:	:	:
cord-264489-h1n9ywbd	218	1	Molecular	molecular	JJ
cord-264489-h1n9ywbd	218	2	evolutionary	evolutionary	JJ
cord-264489-h1n9ywbd	218	3	genetics	genetics	NN
cord-264489-h1n9ywbd	218	4	analysis	analysis	NN
cord-264489-h1n9ywbd	218	5	version	version	NN
cord-264489-h1n9ywbd	218	6	7.0	7.0	CD
cord-264489-h1n9ywbd	218	7	for	for	IN
cord-264489-h1n9ywbd	218	8	bigger	big	JJR
cord-264489-h1n9ywbd	218	9	datasets	dataset	NNS
cord-264489-h1n9ywbd	218	10	The	the	DT
cord-264489-h1n9ywbd	218	11	interplay	interplay	NN
cord-264489-h1n9ywbd	218	12	of	of	IN
cord-264489-h1n9ywbd	218	13	immune	immune	JJ
cord-264489-h1n9ywbd	218	14	components	component	NNS
cord-264489-h1n9ywbd	218	15	and	and	CC
cord-264489-h1n9ywbd	218	16	ECM	ECM	NNP
cord-264489-h1n9ywbd	218	17	in	in	IN
cord-264489-h1n9ywbd	218	18	oral	oral	JJ
cord-264489-h1n9ywbd	218	19	cancer	cancer	NN
cord-264489-h1n9ywbd	218	20	.	.	.
cord-264489-h1n9ywbd	219	1	bioRxiv	biorxiv	RB
cord-264489-h1n9ywbd	220	1	Molecular	molecular	JJ
cord-264489-h1n9ywbd	220	2	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	220	3	simulations	simulation	NNS
cord-264489-h1n9ywbd	220	4	of	of	IN
cord-264489-h1n9ywbd	220	5	hemoglobin	hemoglobin	NN
cord-264489-h1n9ywbd	220	6	A	a	NN
cord-264489-h1n9ywbd	220	7	in	in	IN
cord-264489-h1n9ywbd	220	8	different	different	JJ
cord-264489-h1n9ywbd	220	9	states	state	NNS
cord-264489-h1n9ywbd	220	10	and	and	CC
cord-264489-h1n9ywbd	220	11	bound	bind	VBN
cord-264489-h1n9ywbd	220	12	to	to	IN
cord-264489-h1n9ywbd	220	13	DPG	DPG	NNP
cord-264489-h1n9ywbd	220	14	:	:	:
cord-264489-h1n9ywbd	220	15	effector	effector	NN
cord-264489-h1n9ywbd	220	16	-	-	HYPH
cord-264489-h1n9ywbd	220	17	linked	link	VBN
cord-264489-h1n9ywbd	220	18	perturbation	perturbation	NN
cord-264489-h1n9ywbd	220	19	of	of	IN
cord-264489-h1n9ywbd	220	20	tertiary	tertiary	JJ
cord-264489-h1n9ywbd	220	21	conformations	conformation	NNS
cord-264489-h1n9ywbd	220	22	and	and	CC
cord-264489-h1n9ywbd	220	23	HbA	hba	JJ
cord-264489-h1n9ywbd	220	24	concerted	concerted	JJ
cord-264489-h1n9ywbd	220	25	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	221	1	Comprehensive	comprehensive	JJ
cord-264489-h1n9ywbd	221	2	analyses	analysis	NNS
cord-264489-h1n9ywbd	221	3	of	of	IN
cord-264489-h1n9ywbd	221	4	tissuespecific	tissuespecific	JJ
cord-264489-h1n9ywbd	221	5	networks	network	NNS
cord-264489-h1n9ywbd	221	6	with	with	IN
cord-264489-h1n9ywbd	221	7	implications	implication	NNS
cord-264489-h1n9ywbd	221	8	to	to	IN
cord-264489-h1n9ywbd	221	9	psychiatric	psychiatric	JJ
cord-264489-h1n9ywbd	221	10	diseases	disease	NNS
cord-264489-h1n9ywbd	221	11	Structure	Structure	NNP
cord-264489-h1n9ywbd	221	12	validation	validation	NN
cord-264489-h1n9ywbd	221	13	by	by	IN
cord-264489-h1n9ywbd	221	14	Calpha	Calpha	NNP
cord-264489-h1n9ywbd	221	15	geometry	geometry	NN
cord-264489-h1n9ywbd	221	16	:	:	:
cord-264489-h1n9ywbd	221	17	phi	phi	NNP
cord-264489-h1n9ywbd	221	18	,	,	,
cord-264489-h1n9ywbd	221	19	psi	psi	NNP
cord-264489-h1n9ywbd	221	20	and	and	CC
cord-264489-h1n9ywbd	221	21	Cbeta	Cbeta	NNP
cord-264489-h1n9ywbd	221	22	deviation	deviation	NN
cord-264489-h1n9ywbd	221	23	T	t	NN
cord-264489-h1n9ywbd	221	24	cell	cell	NN
cord-264489-h1n9ywbd	221	25	differentiation	differentiation	NN
cord-264489-h1n9ywbd	221	26	and	and	CC
cord-264489-h1n9ywbd	221	27	effector	effector	NN
cord-264489-h1n9ywbd	221	28	function	function	NN
cord-264489-h1n9ywbd	222	1	SugarBindDB	SugarBindDB	NNP
cord-264489-h1n9ywbd	222	2	,	,	,
cord-264489-h1n9ywbd	223	1	a	a	DT
cord-264489-h1n9ywbd	223	2	resource	resource	NN
cord-264489-h1n9ywbd	223	3	of	of	IN
cord-264489-h1n9ywbd	223	4	glycan	glycan	NN
cord-264489-h1n9ywbd	223	5	-	-	HYPH
cord-264489-h1n9ywbd	223	6	mediated	mediate	VBN
cord-264489-h1n9ywbd	223	7	host	host	NN
cord-264489-h1n9ywbd	223	8	-	-	HYPH
cord-264489-h1n9ywbd	223	9	pathogen	pathogen	NN
cord-264489-h1n9ywbd	223	10	interactions	interaction	NNS
cord-264489-h1n9ywbd	223	11	The	the	DT
cord-264489-h1n9ywbd	223	12	molecular	molecular	JJ
cord-264489-h1n9ywbd	223	13	mystique	mystique	NN
cord-264489-h1n9ywbd	223	14	of	of	IN
cord-264489-h1n9ywbd	223	15	tetrodotoxin	tetrodotoxin	NN
cord-264489-h1n9ywbd	223	16	Expression	expression	NN
cord-264489-h1n9ywbd	223	17	and	and	CC
cord-264489-h1n9ywbd	223	18	responsiveness	responsiveness	NN
cord-264489-h1n9ywbd	223	19	of	of	IN
cord-264489-h1n9ywbd	223	20	human	human	JJ
cord-264489-h1n9ywbd	223	21	interleukin-18	interleukin-18	NN
cord-264489-h1n9ywbd	223	22	receptor	receptor	NN
cord-264489-h1n9ywbd	223	23	(	(	-LRB-
cord-264489-h1n9ywbd	223	24	IL-18R	IL-18R	NNP
cord-264489-h1n9ywbd	223	25	)	)	-RRB-
cord-264489-h1n9ywbd	223	26	on	on	IN
cord-264489-h1n9ywbd	223	27	hematopoietic	hematopoietic	JJ
cord-264489-h1n9ywbd	223	28	cell	cell	NN
cord-264489-h1n9ywbd	223	29	lines	line	NNS
cord-264489-h1n9ywbd	223	30	TRAM	TRAM	NNP
cord-264489-h1n9ywbd	223	31	is	be	VBZ
cord-264489-h1n9ywbd	223	32	involved	involve	VBN
cord-264489-h1n9ywbd	223	33	in	in	IN
cord-264489-h1n9ywbd	223	34	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	223	35	signaling	signal	VBG
cord-264489-h1n9ywbd	223	36	and	and	CC
cord-264489-h1n9ywbd	223	37	functions	function	NNS
cord-264489-h1n9ywbd	223	38	as	as	IN
cord-264489-h1n9ywbd	223	39	a	a	DT
cord-264489-h1n9ywbd	223	40	sorting	sorting	NN
cord-264489-h1n9ywbd	223	41	adaptor	adaptor	NN
cord-264489-h1n9ywbd	223	42	for	for	IN
cord-264489-h1n9ywbd	223	43	MyD88	MyD88	NNP
cord-264489-h1n9ywbd	223	44	Scalable	scalable	JJ
cord-264489-h1n9ywbd	223	45	molecular	molecular	JJ
cord-264489-h1n9ywbd	223	46	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	223	47	with	with	IN
cord-264489-h1n9ywbd	223	48	NAMD	NAMD	NNP
cord-264489-h1n9ywbd	223	49	Molecular	Molecular	NNP
cord-264489-h1n9ywbd	223	50	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	223	51	simulation	simulation	NN
cord-264489-h1n9ywbd	223	52	of	of	IN
cord-264489-h1n9ywbd	223	53	the	the	DT
cord-264489-h1n9ywbd	223	54	nanosecond	nanosecond	NN
cord-264489-h1n9ywbd	223	55	pulsed	pulse	VBN
cord-264489-h1n9ywbd	223	56	electric	electric	JJ
cord-264489-h1n9ywbd	223	57	field	field	NN
cord-264489-h1n9ywbd	223	58	effect	effect	NN
cord-264489-h1n9ywbd	223	59	on	on	IN
cord-264489-h1n9ywbd	223	60	kinesin	kinesin	NN
cord-264489-h1n9ywbd	223	61	nanomotor	nanomotor	NN
cord-264489-h1n9ywbd	223	62	Structural	structural	JJ
cord-264489-h1n9ywbd	223	63	biology	biology	NN
cord-264489-h1n9ywbd	223	64	of	of	IN
cord-264489-h1n9ywbd	223	65	tumor	tumor	NN
cord-264489-h1n9ywbd	223	66	necrosis	necrosis	NN
cord-264489-h1n9ywbd	223	67	factor	factor	NN
cord-264489-h1n9ywbd	223	68	demonstrated	demonstrate	VBN
cord-264489-h1n9ywbd	223	69	for	for	IN
cord-264489-h1n9ywbd	223	70	undergraduate	undergraduate	JJ
cord-264489-h1n9ywbd	223	71	instruction	instruction	NN
cord-264489-h1n9ywbd	223	72	by	by	IN
cord-264489-h1n9ywbd	223	73	computer	computer	NN
cord-264489-h1n9ywbd	223	74	simulation	simulation	NN
cord-264489-h1n9ywbd	223	75	Structural	structural	JJ
cord-264489-h1n9ywbd	223	76	characterizations	characterization	NNS
cord-264489-h1n9ywbd	223	77	of	of	IN
cord-264489-h1n9ywbd	223	78	the	the	DT
cord-264489-h1n9ywbd	223	79	fas	fas	NNP
cord-264489-h1n9ywbd	223	80	Receptor	Receptor	NNP
cord-264489-h1n9ywbd	223	81	and	and	CC
cord-264489-h1n9ywbd	223	82	the	the	DT
cord-264489-h1n9ywbd	223	83	fas	fas	NNP
cord-264489-h1n9ywbd	223	84	-	-	HYPH
cord-264489-h1n9ywbd	223	85	associated	associate	VBN
cord-264489-h1n9ywbd	223	86	protein	protein	NN
cord-264489-h1n9ywbd	223	87	with	with	IN
cord-264489-h1n9ywbd	223	88	death	death	NN
cord-264489-h1n9ywbd	223	89	domain	domain	NN
cord-264489-h1n9ywbd	223	90	interactions	interaction	NNS
cord-264489-h1n9ywbd	223	91	Structural	structural	JJ
cord-264489-h1n9ywbd	223	92	modeling	modeling	NN
cord-264489-h1n9ywbd	223	93	of	of	IN
cord-264489-h1n9ywbd	223	94	tumor	tumor	NN
cord-264489-h1n9ywbd	223	95	necrosis	necrosis	NN
cord-264489-h1n9ywbd	223	96	factor	factor	NN
cord-264489-h1n9ywbd	223	97	:	:	:
cord-264489-h1n9ywbd	223	98	a	a	DT
cord-264489-h1n9ywbd	223	99	protein	protein	NN
cord-264489-h1n9ywbd	223	100	of	of	IN
cord-264489-h1n9ywbd	223	101	immunological	immunological	JJ
cord-264489-h1n9ywbd	223	102	importance	importance	NN
cord-264489-h1n9ywbd	223	103	3D	3d	NN
cord-264489-h1n9ywbd	223	104	modeling	modeling	NN
cord-264489-h1n9ywbd	223	105	of	of	IN
cord-264489-h1n9ywbd	223	106	tumor	tumor	NN
cord-264489-h1n9ywbd	223	107	necrosis	necrosis	NN
cord-264489-h1n9ywbd	223	108	factor	factor	NN
cord-264489-h1n9ywbd	223	109	receptor	receptor	NN
cord-264489-h1n9ywbd	223	110	and	and	CC
cord-264489-h1n9ywbd	223	111	tumor	tumor	NN
cord-264489-h1n9ywbd	223	112	necrosis	necrosis	NN
cord-264489-h1n9ywbd	223	113	factor	factor	NN
cord-264489-h1n9ywbd	223	114	-	-	HYPH
cord-264489-h1n9ywbd	223	115	bound	bind	VBN
cord-264489-h1n9ywbd	223	116	receptor	receptor	NN
cord-264489-h1n9ywbd	223	117	systems	system	NNS
cord-264489-h1n9ywbd	223	118	Structure	structure	NN
cord-264489-h1n9ywbd	223	119	and	and	CC
cord-264489-h1n9ywbd	223	120	function	function	NN
cord-264489-h1n9ywbd	223	121	of	of	IN
cord-264489-h1n9ywbd	223	122	an	an	DT
cord-264489-h1n9ywbd	223	123	inflammatory	inflammatory	JJ
cord-264489-h1n9ywbd	223	124	cytokine	cytokine	NN
cord-264489-h1n9ywbd	223	125	,	,	,
cord-264489-h1n9ywbd	223	126	interleukin-2	interleukin-2	RB
cord-264489-h1n9ywbd	223	127	,	,	,
cord-264489-h1n9ywbd	223	128	analyzed	analyze	VBD
cord-264489-h1n9ywbd	223	129	using	use	VBG
cord-264489-h1n9ywbd	223	130	the	the	DT
cord-264489-h1n9ywbd	223	131	bioinformatic	bioinformatic	JJ
cord-264489-h1n9ywbd	223	132	approach	approach	NN
cord-264489-h1n9ywbd	223	133	Structural	structural	JJ
cord-264489-h1n9ywbd	223	134	and	and	CC
cord-264489-h1n9ywbd	223	135	molecular	molecular	JJ
cord-264489-h1n9ywbd	223	136	analyses	analysis	NNS
cord-264489-h1n9ywbd	223	137	of	of	IN
cord-264489-h1n9ywbd	223	138	functional	functional	JJ
cord-264489-h1n9ywbd	223	139	epitopes	epitope	NNS
cord-264489-h1n9ywbd	223	140	and	and	CC
cord-264489-h1n9ywbd	223	141	escape	escape	VB
cord-264489-h1n9ywbd	223	142	mutants	mutant	NNS
cord-264489-h1n9ywbd	223	143	in	in	IN
cord-264489-h1n9ywbd	223	144	Japanese	japanese	JJ
cord-264489-h1n9ywbd	223	145	encephalitis	encephalitis	RB
cord-264489-h1n9ywbd	223	146	virus	virus	NN
cord-264489-h1n9ywbd	223	147	envelope	envelope	NN
cord-264489-h1n9ywbd	223	148	protein	protein	NN
cord-264489-h1n9ywbd	223	149	domain	domain	NN
cord-264489-h1n9ywbd	223	150	III	iii	CD
cord-264489-h1n9ywbd	223	151	Role	role	NN
cord-264489-h1n9ywbd	223	152	of	of	IN
cord-264489-h1n9ywbd	223	153	protecting	protect	VBG
cord-264489-h1n9ywbd	223	154	groups	group	NNS
cord-264489-h1n9ywbd	223	155	in	in	IN
cord-264489-h1n9ywbd	223	156	the	the	DT
cord-264489-h1n9ywbd	223	157	preparation	preparation	NN
cord-264489-h1n9ywbd	223	158	of	of	IN
cord-264489-h1n9ywbd	223	159	thiolate	thiolate	NN
cord-264489-h1n9ywbd	223	160	complexes	complex	NNS
cord-264489-h1n9ywbd	223	161	of	of	IN
cord-264489-h1n9ywbd	223	162	technetium-99	technetium-99	NN
cord-264489-h1n9ywbd	223	163	m	m	NN
cord-264489-h1n9ywbd	223	164	using	use	VBG
cord-264489-h1n9ywbd	223	165	cysteine	cysteine	NN
cord-264489-h1n9ywbd	223	166	as	as	IN
cord-264489-h1n9ywbd	223	167	a	a	DT
cord-264489-h1n9ywbd	223	168	model	model	NN
cord-264489-h1n9ywbd	223	169	Molecular	molecular	JJ
cord-264489-h1n9ywbd	223	170	modeling	modeling	NN
cord-264489-h1n9ywbd	223	171	of	of	IN
cord-264489-h1n9ywbd	223	172	estrogen	estrogen	NN
cord-264489-h1n9ywbd	223	173	receptor	receptor	NN
cord-264489-h1n9ywbd	223	174	using	use	VBG
cord-264489-h1n9ywbd	223	175	molecular	molecular	JJ
cord-264489-h1n9ywbd	223	176	operating	operate	VBG
cord-264489-h1n9ywbd	223	177	environment	environment	NN
cord-264489-h1n9ywbd	223	178	Cysteine	cysteine	NN
cord-264489-h1n9ywbd	223	179	residues	residue	NNS
cord-264489-h1n9ywbd	223	180	in	in	IN
cord-264489-h1n9ywbd	223	181	heavy	heavy	JJ
cord-264489-h1n9ywbd	223	182	metal	metal	NN
cord-264489-h1n9ywbd	223	183	binding	bind	VBG
cord-264489-h1n9ywbd	223	184	proteins	protein	NNS
cord-264489-h1n9ywbd	223	185	:	:	:
cord-264489-h1n9ywbd	223	186	structural	structural	JJ
cord-264489-h1n9ywbd	223	187	insights	insight	NNS
cord-264489-h1n9ywbd	223	188	and	and	CC
cord-264489-h1n9ywbd	223	189	comparison	comparison	NN
cord-264489-h1n9ywbd	223	190	with	with	IN
cord-264489-h1n9ywbd	223	191	leucine	leucine	NN
cord-264489-h1n9ywbd	223	192	binding	bind	VBG
cord-264489-h1n9ywbd	223	193	protein	protein	NN
cord-264489-h1n9ywbd	223	194	Cytoscape	Cytoscape	NNP
cord-264489-h1n9ywbd	223	195	:	:	:
cord-264489-h1n9ywbd	223	196	a	a	DT
cord-264489-h1n9ywbd	223	197	software	software	NN
cord-264489-h1n9ywbd	223	198	environment	environment	NN
cord-264489-h1n9ywbd	223	199	for	for	IN
cord-264489-h1n9ywbd	223	200	integrated	integrated	JJ
cord-264489-h1n9ywbd	223	201	models	model	NNS
cord-264489-h1n9ywbd	223	202	of	of	IN
cord-264489-h1n9ywbd	223	203	biomolecular	biomolecular	JJ
cord-264489-h1n9ywbd	223	204	interaction	interaction	NN
cord-264489-h1n9ywbd	223	205	networks	network	NNS
cord-264489-h1n9ywbd	223	206	Fast	fast	RB
cord-264489-h1n9ywbd	223	207	,	,	,
cord-264489-h1n9ywbd	223	208	scalable	scalable	JJ
cord-264489-h1n9ywbd	223	209	generation	generation	NN
cord-264489-h1n9ywbd	223	210	of	of	IN
cord-264489-h1n9ywbd	223	211	high	high	JJ
cord-264489-h1n9ywbd	223	212	-	-	HYPH
cord-264489-h1n9ywbd	223	213	quality	quality	NN
cord-264489-h1n9ywbd	223	214	protein	protein	NN
cord-264489-h1n9ywbd	223	215	multiple	multiple	JJ
cord-264489-h1n9ywbd	223	216	sequence	sequence	NN
cord-264489-h1n9ywbd	223	217	alignments	alignment	NNS
cord-264489-h1n9ywbd	223	218	using	use	VBG
cord-264489-h1n9ywbd	223	219	Clustal	Clustal	NNP
cord-264489-h1n9ywbd	223	220	Omega	Omega	NNP
cord-264489-h1n9ywbd	223	221	A	a	DT
cord-264489-h1n9ywbd	223	222	comparative	comparative	JJ
cord-264489-h1n9ywbd	223	223	analysis	analysis	NN
cord-264489-h1n9ywbd	223	224	of	of	IN
cord-264489-h1n9ywbd	223	225	the	the	DT
cord-264489-h1n9ywbd	223	226	foamy	foamy	NNP
cord-264489-h1n9ywbd	223	227	and	and	CC
cord-264489-h1n9ywbd	223	228	ortho	ortho	NNP
cord-264489-h1n9ywbd	223	229	virus	virus	NN
cord-264489-h1n9ywbd	223	230	capsid	capsid	NN
cord-264489-h1n9ywbd	223	231	structures	structure	NNS
cord-264489-h1n9ywbd	223	232	reveals	reveal	VBZ
cord-264489-h1n9ywbd	223	233	an	an	DT
cord-264489-h1n9ywbd	223	234	ancient	ancient	JJ
cord-264489-h1n9ywbd	223	235	domain	domain	NN
cord-264489-h1n9ywbd	223	236	duplication	duplication	NN
cord-264489-h1n9ywbd	224	1	The	the	DT
cord-264489-h1n9ywbd	224	2	structural	structural	JJ
cord-264489-h1n9ywbd	224	3	basis	basis	NN
cord-264489-h1n9ywbd	224	4	for	for	IN
cord-264489-h1n9ywbd	224	5	receptor	receptor	NN
cord-264489-h1n9ywbd	224	6	recognition	recognition	NN
cord-264489-h1n9ywbd	224	7	of	of	IN
cord-264489-h1n9ywbd	224	8	human	human	NN
cord-264489-h1n9ywbd	224	9	interleukin-18	interleukin-18	NNP
cord-264489-h1n9ywbd	224	10	An	an	DT
cord-264489-h1n9ywbd	224	11	innate	innate	JJ
cord-264489-h1n9ywbd	224	12	interaction	interaction	NN
cord-264489-h1n9ywbd	224	13	between	between	IN
cord-264489-h1n9ywbd	224	14	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	224	15	and	and	CC
cord-264489-h1n9ywbd	224	16	the	the	DT
cord-264489-h1n9ywbd	224	17	propeptide	propeptide	NN
cord-264489-h1n9ywbd	224	18	that	that	WDT
cord-264489-h1n9ywbd	224	19	inactivates	inactivate	VBZ
cord-264489-h1n9ywbd	224	20	its	-PRON-	PRP$
cord-264489-h1n9ywbd	224	21	precursor	precursor	NN
cord-264489-h1n9ywbd	224	22	form	form	NN
cord-264489-h1n9ywbd	224	23	Watermediated	watermediate	VBN
cord-264489-h1n9ywbd	224	24	interactions	interaction	NNS
cord-264489-h1n9ywbd	224	25	in	in	IN
cord-264489-h1n9ywbd	224	26	the	the	DT
cord-264489-h1n9ywbd	224	27	CRP	crp	NN
cord-264489-h1n9ywbd	224	28	-	-	HYPH
cord-264489-h1n9ywbd	224	29	cAMP	camp	NN
cord-264489-h1n9ywbd	224	30	-	-	HYPH
cord-264489-h1n9ywbd	224	31	DNA	dna	NN
cord-264489-h1n9ywbd	224	32	complex	complex	NN
cord-264489-h1n9ywbd	224	33	:	:	:
cord-264489-h1n9ywbd	225	1	does	do	VBZ
cord-264489-h1n9ywbd	225	2	water	water	NN
cord-264489-h1n9ywbd	225	3	mediate	mediate	VB
cord-264489-h1n9ywbd	225	4	sequence	sequence	NN
cord-264489-h1n9ywbd	225	5	-	-	HYPH
cord-264489-h1n9ywbd	225	6	specific	specific	JJ
cord-264489-h1n9ywbd	225	7	binding	binding	NN
cord-264489-h1n9ywbd	225	8	at	at	IN
cord-264489-h1n9ywbd	225	9	the	the	DT
cord-264489-h1n9ywbd	225	10	DNA	dna	NN
cord-264489-h1n9ywbd	225	11	primary	primary	JJ
cord-264489-h1n9ywbd	225	12	-	-	HYPH
cord-264489-h1n9ywbd	225	13	kink	kink	NN
cord-264489-h1n9ywbd	225	14	site	site	NN
cord-264489-h1n9ywbd	225	15	?	?	.
cord-264489-h1n9ywbd	226	1	Bioinformatical	Bioinformatical	NNP
cord-264489-h1n9ywbd	226	2	detection	detection	NN
cord-264489-h1n9ywbd	226	3	of	of	IN
cord-264489-h1n9ywbd	226	4	recognition	recognition	NN
cord-264489-h1n9ywbd	226	5	factors	factor	NNS
cord-264489-h1n9ywbd	226	6	for	for	IN
cord-264489-h1n9ywbd	226	7	ubiquitin	ubiquitin	NN
cord-264489-h1n9ywbd	226	8	and	and	CC
cord-264489-h1n9ywbd	226	9	SUMO	SUMO	NNP
cord-264489-h1n9ywbd	226	10	Mesoscopic	Mesoscopic	NNP
cord-264489-h1n9ywbd	226	11	modeling	model	VBG
cord-264489-h1n9ywbd	226	12	as	as	IN
cord-264489-h1n9ywbd	226	13	a	a	DT
cord-264489-h1n9ywbd	226	14	starting	starting	NN
cord-264489-h1n9ywbd	226	15	point	point	NN
cord-264489-h1n9ywbd	226	16	for	for	IN
cord-264489-h1n9ywbd	226	17	computational	computational	JJ
cord-264489-h1n9ywbd	226	18	analyses	analysis	NNS
cord-264489-h1n9ywbd	226	19	of	of	IN
cord-264489-h1n9ywbd	226	20	cystic	cystic	JJ
cord-264489-h1n9ywbd	226	21	fibrosis	fibrosis	NN
cord-264489-h1n9ywbd	226	22	as	as	IN
cord-264489-h1n9ywbd	226	23	a	a	DT
cord-264489-h1n9ywbd	226	24	systemic	systemic	JJ
cord-264489-h1n9ywbd	226	25	disease	disease	NN
cord-264489-h1n9ywbd	226	26	Protein	protein	NN
cord-264489-h1n9ywbd	226	27	-	-	HYPH
cord-264489-h1n9ywbd	226	28	protein	protein	NN
cord-264489-h1n9ywbd	226	29	interaction	interaction	NN
cord-264489-h1n9ywbd	226	30	sites	site	NNS
cord-264489-h1n9ywbd	226	31	prediction	prediction	NN
cord-264489-h1n9ywbd	226	32	by	by	IN
cord-264489-h1n9ywbd	226	33	ensemble	ensemble	JJ
cord-264489-h1n9ywbd	226	34	random	random	JJ
cord-264489-h1n9ywbd	226	35	forests	forest	NNS
cord-264489-h1n9ywbd	226	36	with	with	IN
cord-264489-h1n9ywbd	226	37	synthetic	synthetic	JJ
cord-264489-h1n9ywbd	226	38	minority	minority	NN
cord-264489-h1n9ywbd	226	39	oversampling	oversampling	NN
cord-264489-h1n9ywbd	226	40	technique	technique	NN
cord-264489-h1n9ywbd	226	41	Identification	identification	NN
cord-264489-h1n9ywbd	226	42	of	of	IN
cord-264489-h1n9ywbd	226	43	potential	potential	JJ
cord-264489-h1n9ywbd	226	44	inhibitors	inhibitor	NNS
cord-264489-h1n9ywbd	226	45	of	of	IN
cord-264489-h1n9ywbd	226	46	human	human	JJ
cord-264489-h1n9ywbd	226	47	methionine	methionine	NN
cord-264489-h1n9ywbd	226	48	aminopeptidase	aminopeptidase	NN
cord-264489-h1n9ywbd	226	49	(	(	-LRB-
cord-264489-h1n9ywbd	226	50	type	type	NN
cord-264489-h1n9ywbd	226	51	II	II	NNP
cord-264489-h1n9ywbd	226	52	)	)	-RRB-
cord-264489-h1n9ywbd	226	53	for	for	IN
cord-264489-h1n9ywbd	226	54	cancer	cancer	NN
cord-264489-h1n9ywbd	226	55	therapy	therapy	NN
cord-264489-h1n9ywbd	226	56	:	:	:
cord-264489-h1n9ywbd	226	57	structure	structure	NN
cord-264489-h1n9ywbd	226	58	-	-	HYPH
cord-264489-h1n9ywbd	226	59	based	base	VBN
cord-264489-h1n9ywbd	226	60	virtual	virtual	JJ
cord-264489-h1n9ywbd	226	61	screening	screening	NN
cord-264489-h1n9ywbd	226	62	,	,	,
cord-264489-h1n9ywbd	226	63	ADMET	admet	JJ
cord-264489-h1n9ywbd	226	64	prediction	prediction	NN
cord-264489-h1n9ywbd	226	65	and	and	CC
cord-264489-h1n9ywbd	226	66	molecular	molecular	JJ
cord-264489-h1n9ywbd	226	67	dynamics	dynamic	NNS
cord-264489-h1n9ywbd	226	68	studies	study	NNS
cord-264489-h1n9ywbd	226	69	Multi	Multi	NNP
cord-264489-h1n9ywbd	226	70	-	-	JJ
cord-264489-h1n9ywbd	226	71	omic	omic	JJ
cord-264489-h1n9ywbd	226	72	analysis	analysis	NN
cord-264489-h1n9ywbd	226	73	of	of	IN
cord-264489-h1n9ywbd	226	74	signalling	signal	VBG
cord-264489-h1n9ywbd	226	75	factors	factor	NNS
cord-264489-h1n9ywbd	226	76	in	in	IN
cord-264489-h1n9ywbd	226	77	inflammatory	inflammatory	JJ
cord-264489-h1n9ywbd	226	78	comorbidities	comorbiditie	NNS
cord-264489-h1n9ywbd	226	79	Generation	generation	NN
cord-264489-h1n9ywbd	226	80	of	of	IN
cord-264489-h1n9ywbd	226	81	highly	highly	RB
cord-264489-h1n9ywbd	226	82	stable	stable	JJ
cord-264489-h1n9ywbd	226	83	IL-18	IL-18	NNP
cord-264489-h1n9ywbd	226	84	based	base	VBN
cord-264489-h1n9ywbd	226	85	on	on	IN
cord-264489-h1n9ywbd	226	86	a	a	DT
cord-264489-h1n9ywbd	226	87	ligand	ligand	NN
cord-264489-h1n9ywbd	226	88	-	-	HYPH
cord-264489-h1n9ywbd	226	89	receptor	receptor	NN
cord-264489-h1n9ywbd	226	90	complex	complex	JJ
cord-264489-h1n9ywbd	226	91	structure	structure	NN
cord-264489-h1n9ywbd	226	92	Establishing	establish	VBG
cord-264489-h1n9ywbd	226	93	a	a	DT
cord-264489-h1n9ywbd	226	94	framework	framework	NN
cord-264489-h1n9ywbd	226	95	of	of	IN
cord-264489-h1n9ywbd	226	96	using	use	VBG
cord-264489-h1n9ywbd	226	97	residue	residue	NN
cord-264489-h1n9ywbd	226	98	-	-	HYPH
cord-264489-h1n9ywbd	226	99	residue	residue	NN
cord-264489-h1n9ywbd	226	100	interactions	interaction	NNS
cord-264489-h1n9ywbd	226	101	in	in	IN
cord-264489-h1n9ywbd	226	102	protein	protein	NN
cord-264489-h1n9ywbd	226	103	difference	difference	NN
cord-264489-h1n9ywbd	226	104	network	network	NN
cord-264489-h1n9ywbd	226	105	analysis	analysis	NN
cord-264489-h1n9ywbd	226	106	Role	role	NN
cord-264489-h1n9ywbd	226	107	of	of	IN
cord-264489-h1n9ywbd	226	108	the	the	DT
cord-264489-h1n9ywbd	226	109	inflammasome	inflammasome	NN
cord-264489-h1n9ywbd	226	110	-	-	HYPH
cord-264489-h1n9ywbd	226	111	related	relate	VBN
cord-264489-h1n9ywbd	226	112	cytokines	cytokine	NNS
cord-264489-h1n9ywbd	226	113	Il-1	il-1	RB
cord-264489-h1n9ywbd	226	114	and	and	CC
cord-264489-h1n9ywbd	226	115	Il-18	Il-18	NNP
cord-264489-h1n9ywbd	226	116	during	during	IN
cord-264489-h1n9ywbd	226	117	infection	infection	NN
cord-264489-h1n9ywbd	226	118	with	with	IN
cord-264489-h1n9ywbd	226	119	murine	murine	JJ
cord-264489-h1n9ywbd	226	120	coronavirus	coronavirus	NN
cord-264489-h1n9ywbd	226	121	TMPyP4	TMPyP4	NNP
cord-264489-h1n9ywbd	226	122	porphyrin	porphyrin	NN
cord-264489-h1n9ywbd	226	123	distorts	distort	VBZ
cord-264489-h1n9ywbd	226	124	RNA	RNA	NNP
cord-264489-h1n9ywbd	226	125	Gquadruplex	Gquadruplex	NNP
cord-264489-h1n9ywbd	226	126	structures	structure	NNS
cord-264489-h1n9ywbd	226	127	of	of	IN
cord-264489-h1n9ywbd	226	128	the	the	DT
cord-264489-h1n9ywbd	226	129	disease	disease	NN
cord-264489-h1n9ywbd	226	130	-	-	HYPH
cord-264489-h1n9ywbd	226	131	associated	associate	VBN
cord-264489-h1n9ywbd	226	132	r(GGGGCC)n	r(ggggcc)n	NN
cord-264489-h1n9ywbd	226	133	repeat	repeat	NN
cord-264489-h1n9ywbd	226	134	of	of	IN
cord-264489-h1n9ywbd	226	135	the	the	DT
cord-264489-h1n9ywbd	226	136	C9orf72	C9orf72	NNP
cord-264489-h1n9ywbd	226	137	gene	gene	NN
cord-264489-h1n9ywbd	226	138	and	and	CC
cord-264489-h1n9ywbd	226	139	blocks	block	VBZ
cord-264489-h1n9ywbd	226	140	interaction	interaction	NN
cord-264489-h1n9ywbd	226	141	of	of	IN
cord-264489-h1n9ywbd	226	142	RNA	rna	NN
cord-264489-h1n9ywbd	226	143	-	-	HYPH
cord-264489-h1n9ywbd	226	144	binding	bind	VBG
cord-264489-h1n9ywbd	226	145	proteins	protein	NNS
cord-264489-h1n9ywbd	227	1	Positive	positive	JJ
cord-264489-h1n9ywbd	227	2	regulation	regulation	NN
cord-264489-h1n9ywbd	227	3	of	of	IN
cord-264489-h1n9ywbd	227	4	interleukin-1β	interleukin-1β	NNP
cord-264489-h1n9ywbd	227	5	bioactivity	bioactivity	NN
cord-264489-h1n9ywbd	227	6	by	by	IN
cord-264489-h1n9ywbd	227	7	physiological	physiological	JJ
cord-264489-h1n9ywbd	227	8	ROS	ROS	NNP
cord-264489-h1n9ywbd	227	9	-	-	HYPH
cord-264489-h1n9ywbd	227	10	mediated	mediate	VBN
cord-264489-h1n9ywbd	227	11	cysteine	cysteine	NN
cord-264489-h1n9ywbd	227	12	S	s	NN
cord-264489-h1n9ywbd	227	13	-	-	HYPH
cord-264489-h1n9ywbd	227	14	glutathionylation	glutathionylation	NN
cord-264489-h1n9ywbd	228	1	The	the	DT
cord-264489-h1n9ywbd	228	2	author	author	NN
cord-264489-h1n9ywbd	228	3	acknowledges	acknowledge	VBZ
cord-264489-h1n9ywbd	228	4	utilization	utilization	NN
cord-264489-h1n9ywbd	228	5	of	of	IN
cord-264489-h1n9ywbd	228	6	the	the	DT
cord-264489-h1n9ywbd	228	7	following	follow	VBG
cord-264489-h1n9ywbd	228	8	simulation	simulation	NN
cord-264489-h1n9ywbd	228	9	and	and	CC
cord-264489-h1n9ywbd	228	10	visualization	visualization	NN
cord-264489-h1n9ywbd	228	11	software	software	NN
cord-264489-h1n9ywbd	228	12	 	 	_SP