id sid tid token lemma pos cord-023726-2fduzqyb 1 1 key key JJ cord-023726-2fduzqyb 1 2 : : : cord-023726-2fduzqyb 1 3 cord-023726 cord-023726 JJ cord-023726-2fduzqyb 1 4 - - HYPH cord-023726-2fduzqyb 1 5 2fduzqyb 2fduzqyb CD cord-023726-2fduzqyb 1 6 authors author NNS cord-023726-2fduzqyb 1 7 : : : cord-023726-2fduzqyb 1 8 STRAUSS STRAUSS NNP cord-023726-2fduzqyb 1 9 , , , cord-023726-2fduzqyb 1 10 JAMES JAMES NNP cord-023726-2fduzqyb 1 11 H. H. NNP cord-023726-2fduzqyb 1 12 ; ; : cord-023726-2fduzqyb 1 13 STRAUSS STRAUSS NNP cord-023726-2fduzqyb 1 14 , , , cord-023726-2fduzqyb 2 1 ELLEN ELLEN NNP cord-023726-2fduzqyb 2 2 G. G. NNP cord-023726-2fduzqyb 2 3 title title NN cord-023726-2fduzqyb 2 4 : : : cord-023726-2fduzqyb 3 1 The the DT cord-023726-2fduzqyb 3 2 Structure Structure NNP cord-023726-2fduzqyb 3 3 of of IN cord-023726-2fduzqyb 3 4 Viruses Viruses NNPS cord-023726-2fduzqyb 3 5 date date NN cord-023726-2fduzqyb 3 6 : : : cord-023726-2fduzqyb 3 7 2012 2012 CD cord-023726-2fduzqyb 3 8 - - HYPH cord-023726-2fduzqyb 3 9 07 07 CD cord-023726-2fduzqyb 3 10 - - HYPH cord-023726-2fduzqyb 3 11 27 27 CD cord-023726-2fduzqyb 3 12 journal journal NN cord-023726-2fduzqyb 3 13 : : : cord-023726-2fduzqyb 3 14 Viruses virus NNS cord-023726-2fduzqyb 3 15 and and CC cord-023726-2fduzqyb 3 16 Human Human NNP cord-023726-2fduzqyb 3 17 Disease Disease NNP cord-023726-2fduzqyb 3 18 DOI DOI NNP cord-023726-2fduzqyb 3 19 : : : cord-023726-2fduzqyb 3 20 10.1016 10.1016 CD cord-023726-2fduzqyb 3 21 / / SYM cord-023726-2fduzqyb 3 22 b978 b978 NN cord-023726-2fduzqyb 3 23 - - HYPH cord-023726-2fduzqyb 3 24 0 0 CD cord-023726-2fduzqyb 3 25 - - HYPH cord-023726-2fduzqyb 3 26 12 12 CD cord-023726-2fduzqyb 3 27 - - HYPH cord-023726-2fduzqyb 3 28 373741 373741 CD cord-023726-2fduzqyb 3 29 - - HYPH cord-023726-2fduzqyb 3 30 0.50005 0.50005 CD cord-023726-2fduzqyb 3 31 - - SYM cord-023726-2fduzqyb 3 32 2 2 CD cord-023726-2fduzqyb 3 33 sha sha NN cord-023726-2fduzqyb 3 34 : : : cord-023726-2fduzqyb 3 35 b9b6e0174f8c612a5cc54e780876758e01228f13 b9b6e0174f8c612a5cc54e780876758e01228f13 NNP cord-023726-2fduzqyb 3 36 doc_id doc_id NNPS cord-023726-2fduzqyb 3 37 : : : cord-023726-2fduzqyb 3 38 23726 23726 CD cord-023726-2fduzqyb 3 39 cord_uid cord_uid NNS cord-023726-2fduzqyb 3 40 : : : cord-023726-2fduzqyb 4 1 2fduzqyb 2fduzqyb CD cord-023726-2fduzqyb 4 2 nan nan NNP cord-023726-2fduzqyb 4 3 Virus Virus NNP cord-023726-2fduzqyb 4 4 particles particle NNS cord-023726-2fduzqyb 4 5 , , , cord-023726-2fduzqyb 4 6 called call VBN cord-023726-2fduzqyb 4 7 virions virion NNS cord-023726-2fduzqyb 4 8 , , , cord-023726-2fduzqyb 4 9 contain contain VBP cord-023726-2fduzqyb 4 10 the the DT cord-023726-2fduzqyb 4 11 viral viral JJ cord-023726-2fduzqyb 4 12 genome genome NN cord-023726-2fduzqyb 4 13 encapsidated encapsidate VBN cord-023726-2fduzqyb 4 14 in in IN cord-023726-2fduzqyb 4 15 a a DT cord-023726-2fduzqyb 4 16 protein protein NN cord-023726-2fduzqyb 4 17 coat coat NN cord-023726-2fduzqyb 4 18 . . . cord-023726-2fduzqyb 5 1 The the DT cord-023726-2fduzqyb 5 2 function function NN cord-023726-2fduzqyb 5 3 of of IN cord-023726-2fduzqyb 5 4 the the DT cord-023726-2fduzqyb 5 5 coat coat NN cord-023726-2fduzqyb 5 6 is be VBZ cord-023726-2fduzqyb 5 7 to to TO cord-023726-2fduzqyb 5 8 protect protect VB cord-023726-2fduzqyb 5 9 the the DT cord-023726-2fduzqyb 5 10 genome genome NN cord-023726-2fduzqyb 5 11 of of IN cord-023726-2fduzqyb 5 12 the the DT cord-023726-2fduzqyb 5 13 virus virus NN cord-023726-2fduzqyb 5 14 in in IN cord-023726-2fduzqyb 5 15 the the DT cord-023726-2fduzqyb 5 16 extracellular extracellular JJ cord-023726-2fduzqyb 5 17 environment environment NN cord-023726-2fduzqyb 5 18 as as RB cord-023726-2fduzqyb 5 19 well well RB cord-023726-2fduzqyb 5 20 as as IN cord-023726-2fduzqyb 5 21 to to TO cord-023726-2fduzqyb 5 22 bind bind VB cord-023726-2fduzqyb 5 23 to to IN cord-023726-2fduzqyb 5 24 a a DT cord-023726-2fduzqyb 5 25 new new JJ cord-023726-2fduzqyb 5 26 host host NN cord-023726-2fduzqyb 5 27 cell cell NN cord-023726-2fduzqyb 5 28 and and CC cord-023726-2fduzqyb 5 29 introduce introduce VB cord-023726-2fduzqyb 5 30 the the DT cord-023726-2fduzqyb 5 31 genome genome NN cord-023726-2fduzqyb 5 32 into into IN cord-023726-2fduzqyb 5 33 it -PRON- PRP cord-023726-2fduzqyb 5 34 . . . cord-023726-2fduzqyb 6 1 Viral viral JJ cord-023726-2fduzqyb 6 2 genomes genome NNS cord-023726-2fduzqyb 6 3 are be VBP cord-023726-2fduzqyb 6 4 small small JJ cord-023726-2fduzqyb 6 5 and and CC cord-023726-2fduzqyb 6 6 limited limited JJ cord-023726-2fduzqyb 6 7 in in IN cord-023726-2fduzqyb 6 8 their -PRON- PRP$ cord-023726-2fduzqyb 6 9 coding coding NN cord-023726-2fduzqyb 6 10 capacity capacity NN cord-023726-2fduzqyb 6 11 , , , cord-023726-2fduzqyb 6 12 which which WDT cord-023726-2fduzqyb 6 13 requires require VBZ cord-023726-2fduzqyb 6 14 that that IN cord-023726-2fduzqyb 6 15 three three CD cord-023726-2fduzqyb 6 16 - - HYPH cord-023726-2fduzqyb 6 17 dimensional dimensional JJ cord-023726-2fduzqyb 6 18 virions virion NNS cord-023726-2fduzqyb 6 19 be be VB cord-023726-2fduzqyb 6 20 formed form VBN cord-023726-2fduzqyb 6 21 using use VBG cord-023726-2fduzqyb 6 22 a a DT cord-023726-2fduzqyb 6 23 limited limited JJ cord-023726-2fduzqyb 6 24 number number NN cord-023726-2fduzqyb 6 25 of of IN cord-023726-2fduzqyb 6 26 different different JJ cord-023726-2fduzqyb 6 27 proteins protein NNS cord-023726-2fduzqyb 6 28 . . . cord-023726-2fduzqyb 7 1 For for IN cord-023726-2fduzqyb 7 2 the the DT cord-023726-2fduzqyb 7 3 smallest small JJS cord-023726-2fduzqyb 7 4 viruses virus NNS cord-023726-2fduzqyb 7 5 , , , cord-023726-2fduzqyb 7 6 only only RB cord-023726-2fduzqyb 7 7 one one CD cord-023726-2fduzqyb 7 8 protein protein NN cord-023726-2fduzqyb 7 9 may may MD cord-023726-2fduzqyb 7 10 be be VB cord-023726-2fduzqyb 7 11 used use VBN cord-023726-2fduzqyb 7 12 to to TO cord-023726-2fduzqyb 7 13 construct construct VB cord-023726-2fduzqyb 7 14 the the DT cord-023726-2fduzqyb 7 15 virion virion NN cord-023726-2fduzqyb 7 16 , , , cord-023726-2fduzqyb 7 17 whereas whereas IN cord-023726-2fduzqyb 7 18 the the DT cord-023726-2fduzqyb 7 19 largest large JJS cord-023726-2fduzqyb 7 20 viruses virus NNS cord-023726-2fduzqyb 7 21 may may MD cord-023726-2fduzqyb 7 22 use use VB cord-023726-2fduzqyb 7 23 30 30 CD cord-023726-2fduzqyb 7 24 or or CC cord-023726-2fduzqyb 7 25 more more JJR cord-023726-2fduzqyb 7 26 proteins protein NNS cord-023726-2fduzqyb 7 27 . . . cord-023726-2fduzqyb 8 1 To to TO cord-023726-2fduzqyb 8 2 form form VB cord-023726-2fduzqyb 8 3 a a DT cord-023726-2fduzqyb 8 4 three three CD cord-023726-2fduzqyb 8 5 - - HYPH cord-023726-2fduzqyb 8 6 dimensional dimensional JJ cord-023726-2fduzqyb 8 7 structure structure NN cord-023726-2fduzqyb 8 8 using use VBG cord-023726-2fduzqyb 8 9 only only RB cord-023726-2fduzqyb 8 10 a a DT cord-023726-2fduzqyb 8 11 few few JJ cord-023726-2fduzqyb 8 12 proteins protein NNS cord-023726-2fduzqyb 8 13 requires require VBZ cord-023726-2fduzqyb 8 14 that that IN cord-023726-2fduzqyb 8 15 the the DT cord-023726-2fduzqyb 8 16 structure structure NN cord-023726-2fduzqyb 8 17 must must MD cord-023726-2fduzqyb 8 18 be be VB cord-023726-2fduzqyb 8 19 regular regular JJ cord-023726-2fduzqyb 8 20 , , , cord-023726-2fduzqyb 8 21 with with IN cord-023726-2fduzqyb 8 22 each each DT cord-023726-2fduzqyb 8 23 protein protein NN cord-023726-2fduzqyb 8 24 subunit subunit NN cord-023726-2fduzqyb 8 25 occupying occupy VBG cord-023726-2fduzqyb 8 26 a a DT cord-023726-2fduzqyb 8 27 position position NN cord-023726-2fduzqyb 8 28 at at IN cord-023726-2fduzqyb 8 29 least least JJS cord-023726-2fduzqyb 8 30 approximately approximately RB cord-023726-2fduzqyb 8 31 equivalent equivalent JJ cord-023726-2fduzqyb 8 32 to to IN cord-023726-2fduzqyb 8 33 that that DT cord-023726-2fduzqyb 8 34 occupied occupy VBN cord-023726-2fduzqyb 8 35 by by IN cord-023726-2fduzqyb 8 36 all all DT cord-023726-2fduzqyb 8 37 other other JJ cord-023726-2fduzqyb 8 38 proteins protein NNS cord-023726-2fduzqyb 8 39 of of IN cord-023726-2fduzqyb 8 40 its -PRON- PRP$ cord-023726-2fduzqyb 8 41 class class NN cord-023726-2fduzqyb 8 42 in in IN cord-023726-2fduzqyb 8 43 the the DT cord-023726-2fduzqyb 8 44 final final JJ cord-023726-2fduzqyb 8 45 structure structure NN cord-023726-2fduzqyb 8 46 ( ( -LRB- cord-023726-2fduzqyb 8 47 the the DT cord-023726-2fduzqyb 8 48 principle principle NN cord-023726-2fduzqyb 8 49 of of IN cord-023726-2fduzqyb 8 50 quasi quasi JJ cord-023726-2fduzqyb 8 51 - - JJ cord-023726-2fduzqyb 8 52 equivalence equivalence NN cord-023726-2fduzqyb 8 53 ) ) -RRB- cord-023726-2fduzqyb 8 54 , , , cord-023726-2fduzqyb 8 55 although although IN cord-023726-2fduzqyb 8 56 some some DT cord-023726-2fduzqyb 8 57 viruses virus NNS cord-023726-2fduzqyb 8 58 are be VBP cord-023726-2fduzqyb 8 59 now now RB cord-023726-2fduzqyb 8 60 known know VBN cord-023726-2fduzqyb 8 61 to to TO cord-023726-2fduzqyb 8 62 violate violate VB cord-023726-2fduzqyb 8 63 the the DT cord-023726-2fduzqyb 8 64 principle principle NN cord-023726-2fduzqyb 8 65 of of IN cord-023726-2fduzqyb 8 66 quasi quasi JJ cord-023726-2fduzqyb 8 67 - - JJ cord-023726-2fduzqyb 8 68 equivalence equivalence NN cord-023726-2fduzqyb 8 69 . . . cord-023726-2fduzqyb 9 1 A a DT cord-023726-2fduzqyb 9 2 regular regular JJ cord-023726-2fduzqyb 9 3 three three CD cord-023726-2fduzqyb 9 4 - - HYPH cord-023726-2fduzqyb 9 5 dimensional dimensional JJ cord-023726-2fduzqyb 9 6 structure structure NN cord-023726-2fduzqyb 9 7 can can MD cord-023726-2fduzqyb 9 8 be be VB cord-023726-2fduzqyb 9 9 formed form VBN cord-023726-2fduzqyb 9 10 from from IN cord-023726-2fduzqyb 9 11 repeating repeat VBG cord-023726-2fduzqyb 9 12 subunits subunit NNS cord-023726-2fduzqyb 9 13 using use VBG cord-023726-2fduzqyb 9 14 either either DT cord-023726-2fduzqyb 9 15 helical helical JJ cord-023726-2fduzqyb 9 16 symmetry symmetry NN cord-023726-2fduzqyb 9 17 or or CC cord-023726-2fduzqyb 9 18 icosahedral icosahedral JJ cord-023726-2fduzqyb 9 19 symmetry symmetry NN cord-023726-2fduzqyb 9 20 principles principle NNS cord-023726-2fduzqyb 9 21 . . . cord-023726-2fduzqyb 10 1 In in IN cord-023726-2fduzqyb 10 2 the the DT cord-023726-2fduzqyb 10 3 case case NN cord-023726-2fduzqyb 10 4 of of IN cord-023726-2fduzqyb 10 5 the the DT cord-023726-2fduzqyb 10 6 smallest small JJS cord-023726-2fduzqyb 10 7 viruses virus NNS cord-023726-2fduzqyb 10 8 , , , cord-023726-2fduzqyb 10 9 the the DT cord-023726-2fduzqyb 10 10 final final JJ cord-023726-2fduzqyb 10 11 structure structure NN cord-023726-2fduzqyb 10 12 is be VBZ cord-023726-2fduzqyb 10 13 simple simple JJ cord-023726-2fduzqyb 10 14 and and CC cord-023726-2fduzqyb 10 15 quite quite RB cord-023726-2fduzqyb 10 16 regular regular JJ cord-023726-2fduzqyb 10 17 . . . cord-023726-2fduzqyb 11 1 Larger large JJR cord-023726-2fduzqyb 11 2 viruses virus NNS cord-023726-2fduzqyb 11 3 with with IN cord-023726-2fduzqyb 11 4 more more JJR cord-023726-2fduzqyb 11 5 proteins protein NNS cord-023726-2fduzqyb 11 6 at at IN cord-023726-2fduzqyb 11 7 their -PRON- PRP$ cord-023726-2fduzqyb 11 8 disposal disposal NN cord-023726-2fduzqyb 11 9 can can MD cord-023726-2fduzqyb 11 10 build build VB cord-023726-2fduzqyb 11 11 more more RBR cord-023726-2fduzqyb 11 12 elaborate elaborate JJ cord-023726-2fduzqyb 11 13 structures structure NNS cord-023726-2fduzqyb 11 14 . . . cord-023726-2fduzqyb 12 1 Enveloped envelop VBN cord-023726-2fduzqyb 12 2 viruses virus NNS cord-023726-2fduzqyb 12 3 may may MD cord-023726-2fduzqyb 12 4 be be VB cord-023726-2fduzqyb 12 5 quite quite RB cord-023726-2fduzqyb 12 6 regular regular JJ cord-023726-2fduzqyb 12 7 in in IN cord-023726-2fduzqyb 12 8 construction construction NN cord-023726-2fduzqyb 12 9 or or CC cord-023726-2fduzqyb 12 10 may may MD cord-023726-2fduzqyb 12 11 have have VB cord-023726-2fduzqyb 12 12 irregular irregular JJ cord-023726-2fduzqyb 12 13 features feature NNS cord-023726-2fduzqyb 12 14 , , , cord-023726-2fduzqyb 12 15 because because IN cord-023726-2fduzqyb 12 16 the the DT cord-023726-2fduzqyb 12 17 use use NN cord-023726-2fduzqyb 12 18 of of IN cord-023726-2fduzqyb 12 19 lipid lipid NN cord-023726-2fduzqyb 12 20 envelopes envelope NNS cord-023726-2fduzqyb 12 21 allows allow VBZ cord-023726-2fduzqyb 12 22 irregularities irregularity NNS cord-023726-2fduzqyb 12 23 in in IN cord-023726-2fduzqyb 12 24 construction construction NN cord-023726-2fduzqyb 12 25 . . . cord-023726-2fduzqyb 13 1 Selected select VBN cord-023726-2fduzqyb 13 2 families family NNS cord-023726-2fduzqyb 13 3 of of IN cord-023726-2fduzqyb 13 4 vertebrate vertebrate JJ cord-023726-2fduzqyb 13 5 viruses virus NNS cord-023726-2fduzqyb 13 6 are be VBP cord-023726-2fduzqyb 13 7 listed list VBN cord-023726-2fduzqyb 13 8 in in IN cord-023726-2fduzqyb 13 9 Table Table NNP cord-023726-2fduzqyb 13 10 _SP cord-023726-2fduzqyb 13 11 2 2 CD cord-023726-2fduzqyb 13 12 .1 .1 NNS cord-023726-2fduzqyb 13 13 grouped group VBN cord-023726-2fduzqyb 13 14 by by IN cord-023726-2fduzqyb 13 15 the the DT cord-023726-2fduzqyb 13 16 morphologies morphology NNS cord-023726-2fduzqyb 13 17 of of IN cord-023726-2fduzqyb 13 18 the the DT cord-023726-2fduzqyb 13 19 virions virion NNS cord-023726-2fduzqyb 13 20 . . . cord-023726-2fduzqyb 14 1 Also also RB cord-023726-2fduzqyb 14 2 shown show VBN cord-023726-2fduzqyb 14 3 for for IN cord-023726-2fduzqyb 14 4 each each DT cord-023726-2fduzqyb 14 5 family family NN cord-023726-2fduzqyb 14 6 is be VBZ cord-023726-2fduzqyb 14 7 the the DT cord-023726-2fduzqyb 14 8 presence presence NN cord-023726-2fduzqyb 14 9 or or CC cord-023726-2fduzqyb 14 10 absence absence NN cord-023726-2fduzqyb 14 11 of of IN cord-023726-2fduzqyb 14 12 an an DT cord-023726-2fduzqyb 14 13 envelope envelope NN cord-023726-2fduzqyb 14 14 in in IN cord-023726-2fduzqyb 14 15 the the DT cord-023726-2fduzqyb 14 16 virion virion NN cord-023726-2fduzqyb 14 17 , , , cord-023726-2fduzqyb 14 18 the the DT cord-023726-2fduzqyb 14 19 triangulation triangulation NN cord-023726-2fduzqyb 14 20 number number NN cord-023726-2fduzqyb 14 21 ( ( -LRB- cord-023726-2fduzqyb 14 22 defined define VBN cord-023726-2fduzqyb 14 23 later later RB cord-023726-2fduzqyb 14 24 ) ) -RRB- cord-023726-2fduzqyb 14 25 if if IN cord-023726-2fduzqyb 14 26 the the DT cord-023726-2fduzqyb 14 27 virus virus NN cord-023726-2fduzqyb 14 28 is be VBZ cord-023726-2fduzqyb 14 29 icosahedral icosahedral JJ cord-023726-2fduzqyb 14 30 , , , cord-023726-2fduzqyb 14 31 the the DT cord-023726-2fduzqyb 14 32 morphology morphology NN cord-023726-2fduzqyb 14 33 of of IN cord-023726-2fduzqyb 14 34 the the DT cord-023726-2fduzqyb 14 35 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 14 36 or or CC cord-023726-2fduzqyb 14 37 core core NN cord-023726-2fduzqyb 14 38 , , , cord-023726-2fduzqyb 14 39 and and CC cord-023726-2fduzqyb 14 40 figure figure NN cord-023726-2fduzqyb 14 41 numbers number NNS cord-023726-2fduzqyb 14 42 where where WRB cord-023726-2fduzqyb 14 43 the the DT cord-023726-2fduzqyb 14 44 structures structure NNS cord-023726-2fduzqyb 14 45 of of IN cord-023726-2fduzqyb 14 46 members member NNS cord-023726-2fduzqyb 14 47 of of IN cord-023726-2fduzqyb 14 48 a a DT cord-023726-2fduzqyb 14 49 family family NN cord-023726-2fduzqyb 14 50 are be VBP cord-023726-2fduzqyb 14 51 illustrated illustrate VBN cord-023726-2fduzqyb 14 52 . . . cord-023726-2fduzqyb 15 1 Electron electron NN cord-023726-2fduzqyb 15 2 micrographs micrograph NNS cord-023726-2fduzqyb 15 3 of of IN cord-023726-2fduzqyb 15 4 five five CD cord-023726-2fduzqyb 15 5 DNA dna NN cord-023726-2fduzqyb 15 6 viruses virus NNS cord-023726-2fduzqyb 15 7 belonging belong VBG cord-023726-2fduzqyb 15 8 to to IN cord-023726-2fduzqyb 15 9 different different JJ cord-023726-2fduzqyb 15 10 families family NNS cord-023726-2fduzqyb 15 11 and and CC cord-023726-2fduzqyb 15 12 of of IN cord-023726-2fduzqyb 15 13 five five CD cord-023726-2fduzqyb 15 14 RNA RNA NNP cord-023726-2fduzqyb 15 15 viruses virus NNS cord-023726-2fduzqyb 15 16 belonging belong VBG cord-023726-2fduzqyb 15 17 to to IN cord-023726-2fduzqyb 15 18 different different JJ cord-023726-2fduzqyb 15 19 families family NNS cord-023726-2fduzqyb 15 20 are be VBP cord-023726-2fduzqyb 15 21 shown show VBN cord-023726-2fduzqyb 15 22 in in IN cord-023726-2fduzqyb 15 23 Fig Fig NNP cord-023726-2fduzqyb 15 24 . . . cord-023726-2fduzqyb 16 1 2 2 LS cord-023726-2fduzqyb 16 2 .1 .1 NFP cord-023726-2fduzqyb 16 3 . . . cord-023726-2fduzqyb 17 1 The the DT cord-023726-2fduzqyb 17 2 viruses virus NNS cord-023726-2fduzqyb 17 3 chosen choose VBN cord-023726-2fduzqyb 17 4 represent represent VBP cord-023726-2fduzqyb 17 5 viruses virus NNS cord-023726-2fduzqyb 17 6 that that WDT cord-023726-2fduzqyb 17 7 are be VBP cord-023726-2fduzqyb 17 8 among among IN cord-023726-2fduzqyb 17 9 the the DT cord-023726-2fduzqyb 17 10 largest large JJS cord-023726-2fduzqyb 17 11 known know VBN cord-023726-2fduzqyb 17 12 and and CC cord-023726-2fduzqyb 17 13 the the DT cord-023726-2fduzqyb 17 14 smallest smallest RBS cord-023726-2fduzqyb 17 15 known know VBN cord-023726-2fduzqyb 17 16 , , , cord-023726-2fduzqyb 17 17 and and CC cord-023726-2fduzqyb 17 18 are be VBP cord-023726-2fduzqyb 17 19 all all DT cord-023726-2fduzqyb 17 20 shown show VBN cord-023726-2fduzqyb 17 21 to to IN cord-023726-2fduzqyb 17 22 the the DT cord-023726-2fduzqyb 17 23 same same JJ cord-023726-2fduzqyb 17 24 scale scale NN cord-023726-2fduzqyb 17 25 for for IN cord-023726-2fduzqyb 17 26 comparison comparison NN cord-023726-2fduzqyb 17 27 . . . cord-023726-2fduzqyb 18 1 For for IN cord-023726-2fduzqyb 18 2 each each DT cord-023726-2fduzqyb 18 3 virus virus NN cord-023726-2fduzqyb 18 4 , , , cord-023726-2fduzqyb 18 5 the the DT cord-023726-2fduzqyb 18 6 top top JJ cord-023726-2fduzqyb 18 7 micrograph micrograph NN cord-023726-2fduzqyb 18 8 is be VBZ cord-023726-2fduzqyb 18 9 of of IN cord-023726-2fduzqyb 18 10 a a DT cord-023726-2fduzqyb 18 11 virus virus NN cord-023726-2fduzqyb 18 12 that that WDT cord-023726-2fduzqyb 18 13 has have VBZ cord-023726-2fduzqyb 18 14 been be VBN cord-023726-2fduzqyb 18 15 negatively negatively RB cord-023726-2fduzqyb 18 16 stained stain VBN cord-023726-2fduzqyb 18 17 , , , cord-023726-2fduzqyb 18 18 the the DT cord-023726-2fduzqyb 18 19 middle middle JJ cord-023726-2fduzqyb 18 20 micrograph micrograph NN cord-023726-2fduzqyb 18 21 is be VBZ cord-023726-2fduzqyb 18 22 of of IN cord-023726-2fduzqyb 18 23 a a DT cord-023726-2fduzqyb 18 24 section section NN cord-023726-2fduzqyb 18 25 of of IN cord-023726-2fduzqyb 18 26 infected infected JJ cord-023726-2fduzqyb 18 27 cells cell NNS cord-023726-2fduzqyb 18 28 , , , cord-023726-2fduzqyb 18 29 and and CC cord-023726-2fduzqyb 18 30 the the DT cord-023726-2fduzqyb 18 31 bottom bottom JJ cord-023726-2fduzqyb 18 32 panel panel NN cord-023726-2fduzqyb 18 33 shows show VBZ cord-023726-2fduzqyb 18 34 a a DT cord-023726-2fduzqyb 18 35 schematic schematic JJ cord-023726-2fduzqyb 18 36 representation representation NN cord-023726-2fduzqyb 18 37 of of IN cord-023726-2fduzqyb 18 38 the the DT cord-023726-2fduzqyb 18 39 virus virus NN cord-023726-2fduzqyb 18 40 . . . cord-023726-2fduzqyb 19 1 The the DT cord-023726-2fduzqyb 19 2 structures structure NNS cord-023726-2fduzqyb 19 3 of of IN cord-023726-2fduzqyb 19 4 these these DT cord-023726-2fduzqyb 19 5 and and CC cord-023726-2fduzqyb 19 6 other other JJ cord-023726-2fduzqyb 19 7 viruses virus NNS cord-023726-2fduzqyb 19 8 are be VBP cord-023726-2fduzqyb 19 9 described describe VBN cord-023726-2fduzqyb 19 10 next next RB cord-023726-2fduzqyb 19 11 . . . cord-023726-2fduzqyb 20 1 Helical helical JJ cord-023726-2fduzqyb 20 2 viruses virus NNS cord-023726-2fduzqyb 20 3 appear appear VBP cord-023726-2fduzqyb 20 4 rod rod NN cord-023726-2fduzqyb 20 5 shaped shape VBN cord-023726-2fduzqyb 20 6 in in IN cord-023726-2fduzqyb 20 7 the the DT cord-023726-2fduzqyb 20 8 electron electron NN cord-023726-2fduzqyb 20 9 microscope microscope NN cord-023726-2fduzqyb 20 10 . . . cord-023726-2fduzqyb 21 1 The the DT cord-023726-2fduzqyb 21 2 rod rod NN cord-023726-2fduzqyb 21 3 can can MD cord-023726-2fduzqyb 21 4 be be VB cord-023726-2fduzqyb 21 5 flexible flexible JJ cord-023726-2fduzqyb 21 6 or or CC cord-023726-2fduzqyb 21 7 stiff stiff JJ cord-023726-2fduzqyb 21 8 . . . cord-023726-2fduzqyb 22 1 The the DT cord-023726-2fduzqyb 22 2 best well RBS cord-023726-2fduzqyb 22 3 studied study VBN cord-023726-2fduzqyb 22 4 example example NN cord-023726-2fduzqyb 22 5 of of IN cord-023726-2fduzqyb 22 6 a a DT cord-023726-2fduzqyb 22 7 simple simple JJ cord-023726-2fduzqyb 22 8 helical helical JJ cord-023726-2fduzqyb 22 9 virus virus NN cord-023726-2fduzqyb 22 10 is be VBZ cord-023726-2fduzqyb 22 11 tobacco tobacco NN cord-023726-2fduzqyb 22 12 mosaic mosaic JJ cord-023726-2fduzqyb 22 13 virus virus NN cord-023726-2fduzqyb 22 14 ( ( -LRB- cord-023726-2fduzqyb 22 15 TMV TMV NNP cord-023726-2fduzqyb 22 16 ) ) -RRB- cord-023726-2fduzqyb 22 17 . . . cord-023726-2fduzqyb 23 1 The the DT cord-023726-2fduzqyb 23 2 TMV TMV NNP cord-023726-2fduzqyb 23 3 virion virion NN cord-023726-2fduzqyb 23 4 is be VBZ cord-023726-2fduzqyb 23 5 a a DT cord-023726-2fduzqyb 23 6 rigid rigid JJ cord-023726-2fduzqyb 23 7 rod rod NN cord-023726-2fduzqyb 23 8 18 18 CD cord-023726-2fduzqyb 23 9 nm nm NN cord-023726-2fduzqyb 23 10 in in IN cord-023726-2fduzqyb 23 11 diameter diameter NN cord-023726-2fduzqyb 23 12 and and CC cord-023726-2fduzqyb 23 13 300 300 CD cord-023726-2fduzqyb 23 14 nm nm NN cord-023726-2fduzqyb 23 15 long long JJ cord-023726-2fduzqyb 24 1 ( ( -LRB- cord-023726-2fduzqyb 24 2 Fig Fig NNP cord-023726-2fduzqyb 24 3 . . . cord-023726-2fduzqyb 24 4 2.2B 2.2b CD cord-023726-2fduzqyb 24 5 ) ) -RRB- cord-023726-2fduzqyb 24 6 . . . cord-023726-2fduzqyb 25 1 It -PRON- PRP cord-023726-2fduzqyb 25 2 contains contain VBZ cord-023726-2fduzqyb 25 3 2130 2130 CD cord-023726-2fduzqyb 25 4 copies copy NNS cord-023726-2fduzqyb 25 5 of of IN cord-023726-2fduzqyb 25 6 a a DT cord-023726-2fduzqyb 25 7 single single JJ cord-023726-2fduzqyb 25 8 capsid capsid NN cord-023726-2fduzqyb 25 9 protein protein NN cord-023726-2fduzqyb 25 10 of of IN cord-023726-2fduzqyb 25 11 17.5 17.5 CD cord-023726-2fduzqyb 25 12 kDa kDa NNS cord-023726-2fduzqyb 25 13 . . . cord-023726-2fduzqyb 26 1 In in IN cord-023726-2fduzqyb 26 2 the the DT cord-023726-2fduzqyb 26 3 right right JJ cord-023726-2fduzqyb 26 4 - - HYPH cord-023726-2fduzqyb 26 5 hand hand NN cord-023726-2fduzqyb 26 6 helix helix NN cord-023726-2fduzqyb 26 7 , , , cord-023726-2fduzqyb 26 8 each each DT cord-023726-2fduzqyb 26 9 protein protein NN cord-023726-2fduzqyb 26 10 subunit subunit NN cord-023726-2fduzqyb 26 11 has have VBZ cord-023726-2fduzqyb 26 12 six six CD cord-023726-2fduzqyb 26 13 nearest near JJS cord-023726-2fduzqyb 26 14 neighbors neighbor NNS cord-023726-2fduzqyb 26 15 and and CC cord-023726-2fduzqyb 26 16 each each DT cord-023726-2fduzqyb 26 17 subunit subunit NN cord-023726-2fduzqyb 26 18 occupies occupy VBZ cord-023726-2fduzqyb 26 19 a a DT cord-023726-2fduzqyb 26 20 position position NN cord-023726-2fduzqyb 26 21 equivalent equivalent JJ cord-023726-2fduzqyb 26 22 to to IN cord-023726-2fduzqyb 26 23 every every DT cord-023726-2fduzqyb 26 24 other other JJ cord-023726-2fduzqyb 26 25 capsid capsid NN cord-023726-2fduzqyb 26 26 protein protein NN cord-023726-2fduzqyb 26 27 subunit subunit NN cord-023726-2fduzqyb 26 28 in in IN cord-023726-2fduzqyb 26 29 the the DT cord-023726-2fduzqyb 26 30 resulting result VBG cord-023726-2fduzqyb 26 31 network network NN cord-023726-2fduzqyb 26 32 ( ( -LRB- cord-023726-2fduzqyb 26 33 Fig Fig NNP cord-023726-2fduzqyb 26 34 . . . cord-023726-2fduzqyb 26 35 2.2A 2.2A NNP cord-023726-2fduzqyb 26 36 ) ) -RRB- cord-023726-2fduzqyb 26 37 , , , cord-023726-2fduzqyb 26 38 except except IN cord-023726-2fduzqyb 26 39 for for IN cord-023726-2fduzqyb 26 40 those those DT cord-023726-2fduzqyb 26 41 subunits subunit NNS cord-023726-2fduzqyb 26 42 at at IN cord-023726-2fduzqyb 26 43 the the DT cord-023726-2fduzqyb 26 44 very very JJ cord-023726-2fduzqyb 26 45 ends end NNS cord-023726-2fduzqyb 26 46 of of IN cord-023726-2fduzqyb 26 47 the the DT cord-023726-2fduzqyb 26 48 helix helix NN cord-023726-2fduzqyb 26 49 . . . cord-023726-2fduzqyb 27 1 Each each DT cord-023726-2fduzqyb 27 2 capsid capsid NN cord-023726-2fduzqyb 27 3 molecule molecule NN cord-023726-2fduzqyb 27 4 binds bind VBZ cord-023726-2fduzqyb 27 5 three three CD cord-023726-2fduzqyb 27 6 nucleotides nucleotide NNS cord-023726-2fduzqyb 27 7 of of IN cord-023726-2fduzqyb 27 8 RNA RNA NNP cord-023726-2fduzqyb 27 9 within within IN cord-023726-2fduzqyb 27 10 a a DT cord-023726-2fduzqyb 27 11 groove groove NN cord-023726-2fduzqyb 27 12 in in IN cord-023726-2fduzqyb 27 13 the the DT cord-023726-2fduzqyb 27 14 protein protein NN cord-023726-2fduzqyb 27 15 . . . cord-023726-2fduzqyb 28 1 The the DT cord-023726-2fduzqyb 28 2 helix helix NN cord-023726-2fduzqyb 28 3 has have VBZ cord-023726-2fduzqyb 28 4 a a DT cord-023726-2fduzqyb 28 5 pitch pitch NN cord-023726-2fduzqyb 28 6 of of IN cord-023726-2fduzqyb 28 7 23 23 CD cord-023726-2fduzqyb 28 8 Å å NN cord-023726-2fduzqyb 28 9 and and CC cord-023726-2fduzqyb 28 10 there there EX cord-023726-2fduzqyb 28 11 are be VBP cord-023726-2fduzqyb 28 12 16 16 CD cord-023726-2fduzqyb 28 13 1 1 CD cord-023726-2fduzqyb 28 14 /3 /3 NNP cord-023726-2fduzqyb 28 15 subunits subunit NNS cord-023726-2fduzqyb 28 16 per per IN cord-023726-2fduzqyb 28 17 turn turn NN cord-023726-2fduzqyb 28 18 of of IN cord-023726-2fduzqyb 28 19 the the DT cord-023726-2fduzqyb 28 20 helix helix NN cord-023726-2fduzqyb 28 21 . . . cord-023726-2fduzqyb 29 1 The the DT cord-023726-2fduzqyb 29 2 length length NN cord-023726-2fduzqyb 29 3 of of IN cord-023726-2fduzqyb 29 4 the the DT cord-023726-2fduzqyb 29 5 TMV TMV NNP cord-023726-2fduzqyb 29 6 virion virion NN cord-023726-2fduzqyb 29 7 ( ( -LRB- cord-023726-2fduzqyb 29 8 300 300 CD cord-023726-2fduzqyb 29 9 nm nm NN cord-023726-2fduzqyb 29 10 ) ) -RRB- cord-023726-2fduzqyb 29 11 is be VBZ cord-023726-2fduzqyb 29 12 determined determine VBN cord-023726-2fduzqyb 29 13 by by IN cord-023726-2fduzqyb 29 14 the the DT cord-023726-2fduzqyb 29 15 size size NN cord-023726-2fduzqyb 29 16 of of IN cord-023726-2fduzqyb 29 17 the the DT cord-023726-2fduzqyb 29 18 RNA RNA NNP cord-023726-2fduzqyb 29 19 ( ( -LRB- cord-023726-2fduzqyb 29 20 6.4 6.4 CD cord-023726-2fduzqyb 29 21 kb kb NNP cord-023726-2fduzqyb 29 22 ) ) -RRB- cord-023726-2fduzqyb 29 23 . . . cord-023726-2fduzqyb 30 1 Many many JJ cord-023726-2fduzqyb 30 2 viruses virus NNS cord-023726-2fduzqyb 30 3 are be VBP cord-023726-2fduzqyb 30 4 constructed construct VBN cord-023726-2fduzqyb 30 5 with with IN cord-023726-2fduzqyb 30 6 helical helical JJ cord-023726-2fduzqyb 30 7 symmetry symmetry NN cord-023726-2fduzqyb 30 8 and and CC cord-023726-2fduzqyb 30 9 often often RB cord-023726-2fduzqyb 30 10 contain contain VBP cord-023726-2fduzqyb 30 11 only only RB cord-023726-2fduzqyb 30 12 one one CD cord-023726-2fduzqyb 30 13 protein protein NN cord-023726-2fduzqyb 30 14 or or CC cord-023726-2fduzqyb 30 15 a a DT cord-023726-2fduzqyb 30 16 very very RB cord-023726-2fduzqyb 30 17 few few JJ cord-023726-2fduzqyb 30 18 proteins protein NNS cord-023726-2fduzqyb 30 19 . . . cord-023726-2fduzqyb 31 1 The the DT cord-023726-2fduzqyb 31 2 popularity popularity NN cord-023726-2fduzqyb 31 3 of of IN cord-023726-2fduzqyb 31 4 the the DT cord-023726-2fduzqyb 31 5 helix helix NN cord-023726-2fduzqyb 31 6 may may MD cord-023726-2fduzqyb 31 7 be be VB cord-023726-2fduzqyb 31 8 due due JJ cord-023726-2fduzqyb 31 9 in in IN cord-023726-2fduzqyb 31 10 part part NN cord-023726-2fduzqyb 31 11 to to IN cord-023726-2fduzqyb 31 12 the the DT cord-023726-2fduzqyb 31 13 fact fact NN cord-023726-2fduzqyb 31 14 that that IN cord-023726-2fduzqyb 31 15 the the DT cord-023726-2fduzqyb 31 16 length length NN cord-023726-2fduzqyb 31 17 of of IN cord-023726-2fduzqyb 31 18 the the DT cord-023726-2fduzqyb 31 19 particle particle NN cord-023726-2fduzqyb 31 20 is be VBZ cord-023726-2fduzqyb 31 21 not not RB cord-023726-2fduzqyb 31 22 fixed fix VBN cord-023726-2fduzqyb 31 23 and and CC cord-023726-2fduzqyb 31 24 RNAs rna NNS cord-023726-2fduzqyb 31 25 or or CC cord-023726-2fduzqyb 31 26 DNAs dna NNS cord-023726-2fduzqyb 31 27 of of IN cord-023726-2fduzqyb 31 28 different different JJ cord-023726-2fduzqyb 31 29 sizes size NNS cord-023726-2fduzqyb 31 30 can can MD cord-023726-2fduzqyb 31 31 be be VB cord-023726-2fduzqyb 31 32 readily readily RB cord-023726-2fduzqyb 31 33 accommodated accommodate VBN cord-023726-2fduzqyb 31 34 . . . cord-023726-2fduzqyb 32 1 Thus thus RB cord-023726-2fduzqyb 32 2 the the DT cord-023726-2fduzqyb 32 3 genome genome NN cord-023726-2fduzqyb 32 4 size size NN cord-023726-2fduzqyb 32 5 is be VBZ cord-023726-2fduzqyb 32 6 not not RB cord-023726-2fduzqyb 32 7 fixed fix VBN cord-023726-2fduzqyb 32 8 , , , cord-023726-2fduzqyb 32 9 unlike unlike IN cord-023726-2fduzqyb 32 10 that that DT cord-023726-2fduzqyb 32 11 of of IN cord-023726-2fduzqyb 32 12 icosahedral icosahedral JJ cord-023726-2fduzqyb 32 13 viruses virus NNS cord-023726-2fduzqyb 32 14 . . . cord-023726-2fduzqyb 32 15 _SP cord-023726-2fduzqyb 33 1 Virions virion NNS cord-023726-2fduzqyb 33 2 can can MD cord-023726-2fduzqyb 33 3 be be VB cord-023726-2fduzqyb 33 4 approximately approximately RB cord-023726-2fduzqyb 33 5 spherical spherical JJ cord-023726-2fduzqyb 33 6 in in IN cord-023726-2fduzqyb 33 7 shape shape NN cord-023726-2fduzqyb 33 8 , , , cord-023726-2fduzqyb 33 9 based base VBN cord-023726-2fduzqyb 33 10 on on IN cord-023726-2fduzqyb 33 11 icosahedral icosahedral JJ cord-023726-2fduzqyb 33 12 symmetry symmetry NN cord-023726-2fduzqyb 33 13 . . . cord-023726-2fduzqyb 34 1 Since since IN cord-023726-2fduzqyb 34 2 the the DT cord-023726-2fduzqyb 34 3 time time NN cord-023726-2fduzqyb 34 4 of of IN cord-023726-2fduzqyb 34 5 Euclid Euclid NNP cord-023726-2fduzqyb 34 6 , , , cord-023726-2fduzqyb 34 7 there there EX cord-023726-2fduzqyb 34 8 have have VBP cord-023726-2fduzqyb 34 9 been be VBN cord-023726-2fduzqyb 34 10 known know VBN cord-023726-2fduzqyb 34 11 to to TO cord-023726-2fduzqyb 34 12 exist exist VB cord-023726-2fduzqyb 34 13 only only RB cord-023726-2fduzqyb 34 14 five five CD cord-023726-2fduzqyb 34 15 regular regular JJ cord-023726-2fduzqyb 34 16 solids solid NNS cord-023726-2fduzqyb 34 17 in in IN cord-023726-2fduzqyb 34 18 which which WDT cord-023726-2fduzqyb 34 19 each each DT cord-023726-2fduzqyb 34 20 face face NN cord-023726-2fduzqyb 34 21 of of IN cord-023726-2fduzqyb 34 22 the the DT cord-023726-2fduzqyb 34 23 solid solid NN cord-023726-2fduzqyb 34 24 is be VBZ cord-023726-2fduzqyb 34 25 a a DT cord-023726-2fduzqyb 34 26 regular regular JJ cord-023726-2fduzqyb 34 27 polygon polygon NN cord-023726-2fduzqyb 34 28 : : : cord-023726-2fduzqyb 34 29 the the DT cord-023726-2fduzqyb 34 30 tetrahedron tetrahedron NN cord-023726-2fduzqyb 34 31 , , , cord-023726-2fduzqyb 34 32 the the DT cord-023726-2fduzqyb 34 33 cube cube NN cord-023726-2fduzqyb 34 34 , , , cord-023726-2fduzqyb 34 35 the the DT cord-023726-2fduzqyb 34 36 octahedron octahedron NN cord-023726-2fduzqyb 34 37 , , , cord-023726-2fduzqyb 34 38 the the DT cord-023726-2fduzqyb 34 39 dodecahedron dodecahedron NN cord-023726-2fduzqyb 34 40 , , , cord-023726-2fduzqyb 34 41 and and CC cord-023726-2fduzqyb 34 42 the the DT cord-023726-2fduzqyb 34 43 icosahedron icosahedron NN cord-023726-2fduzqyb 34 44 . . . cord-023726-2fduzqyb 35 1 The the DT cord-023726-2fduzqyb 35 2 icosahedron icosahedron NN cord-023726-2fduzqyb 35 3 has have VBZ cord-023726-2fduzqyb 35 4 20 20 CD cord-023726-2fduzqyb 35 5 faces face NNS cord-023726-2fduzqyb 35 6 , , , cord-023726-2fduzqyb 35 7 each each DT cord-023726-2fduzqyb 35 8 of of IN cord-023726-2fduzqyb 35 9 which which WDT cord-023726-2fduzqyb 35 10 is be VBZ cord-023726-2fduzqyb 35 11 a a DT cord-023726-2fduzqyb 35 12 regular regular JJ cord-023726-2fduzqyb 35 13 triangle triangle NN cord-023726-2fduzqyb 35 14 , , , cord-023726-2fduzqyb 35 15 and and CC cord-023726-2fduzqyb 35 16 thus thus RB cord-023726-2fduzqyb 35 17 each each DT cord-023726-2fduzqyb 35 18 face face NN cord-023726-2fduzqyb 35 19 has have VBZ cord-023726-2fduzqyb 35 20 threefold threefold JJ cord-023726-2fduzqyb 35 21 rotational rotational JJ cord-023726-2fduzqyb 35 22 symmetry symmetry NN cord-023726-2fduzqyb 35 23 ( ( -LRB- cord-023726-2fduzqyb 35 24 Fig fig NN cord-023726-2fduzqyb 35 25 . . . cord-023726-2fduzqyb 35 26 2.3A 2.3A NNP cord-023726-2fduzqyb 35 27 ) ) -RRB- cord-023726-2fduzqyb 35 28 . . . cord-023726-2fduzqyb 36 1 There there EX cord-023726-2fduzqyb 36 2 are be VBP cord-023726-2fduzqyb 36 3 12 12 CD cord-023726-2fduzqyb 36 4 vertices vertex NNS cord-023726-2fduzqyb 36 5 where where WRB cord-023726-2fduzqyb 36 6 5 5 CD cord-023726-2fduzqyb 36 7 faces face NNS cord-023726-2fduzqyb 36 8 meet meet VBP cord-023726-2fduzqyb 36 9 , , , cord-023726-2fduzqyb 36 10 and and CC cord-023726-2fduzqyb 36 11 thus thus RB cord-023726-2fduzqyb 36 12 each each DT cord-023726-2fduzqyb 36 13 vertex vertex NN cord-023726-2fduzqyb 36 14 has have VBZ cord-023726-2fduzqyb 36 15 fivefold fivefold JJ cord-023726-2fduzqyb 36 16 rotational rotational JJ cord-023726-2fduzqyb 36 17 symmetry symmetry NN cord-023726-2fduzqyb 36 18 . . . cord-023726-2fduzqyb 37 1 There there EX cord-023726-2fduzqyb 37 2 are be VBP cord-023726-2fduzqyb 37 3 30 30 CD cord-023726-2fduzqyb 37 4 edges edge NNS cord-023726-2fduzqyb 37 5 in in IN cord-023726-2fduzqyb 37 6 which which WDT cord-023726-2fduzqyb 37 7 2 2 CD cord-023726-2fduzqyb 37 8 faces face NNS cord-023726-2fduzqyb 37 9 meet meet VBP cord-023726-2fduzqyb 37 10 , , , cord-023726-2fduzqyb 37 11 and and CC cord-023726-2fduzqyb 37 12 each each DT cord-023726-2fduzqyb 37 13 edge edge NN cord-023726-2fduzqyb 37 14 possesses possess VBZ cord-023726-2fduzqyb 37 15 twofold twofold JJ cord-023726-2fduzqyb 37 16 rotational rotational JJ cord-023726-2fduzqyb 37 17 symmetry symmetry NN cord-023726-2fduzqyb 37 18 . . . cord-023726-2fduzqyb 38 1 Thus thus RB cord-023726-2fduzqyb 38 2 the the DT cord-023726-2fduzqyb 38 3 icosahedron icosahedron NN cord-023726-2fduzqyb 38 4 is be VBZ cord-023726-2fduzqyb 38 5 characterized characterize VBN cord-023726-2fduzqyb 38 6 by by IN cord-023726-2fduzqyb 38 7 twofold twofold RB cord-023726-2fduzqyb 38 8 , , , cord-023726-2fduzqyb 38 9 threefold threefold JJ cord-023726-2fduzqyb 38 10 , , , cord-023726-2fduzqyb 38 11 and and CC cord-023726-2fduzqyb 38 12 fivefold fivefold JJ cord-023726-2fduzqyb 38 13 symmetry symmetry NN cord-023726-2fduzqyb 38 14 axes axis NNS cord-023726-2fduzqyb 38 15 . . . cord-023726-2fduzqyb 39 1 The the DT cord-023726-2fduzqyb 39 2 dodecahedron dodecahedron NN cord-023726-2fduzqyb 39 3 , , , cord-023726-2fduzqyb 39 4 the the DT cord-023726-2fduzqyb 39 5 next next JJ cord-023726-2fduzqyb 39 6 simpler simple JJR cord-023726-2fduzqyb 39 7 regular regular JJ cord-023726-2fduzqyb 39 8 solid solid NN cord-023726-2fduzqyb 39 9 , , , cord-023726-2fduzqyb 39 10 has have VBZ cord-023726-2fduzqyb 39 11 the the DT cord-023726-2fduzqyb 39 12 same same JJ cord-023726-2fduzqyb 39 13 symmetry symmetry NN cord-023726-2fduzqyb 39 14 axes axis NNS cord-023726-2fduzqyb 39 15 as as IN cord-023726-2fduzqyb 39 16 the the DT cord-023726-2fduzqyb 39 17 icosahedron icosahedron NN cord-023726-2fduzqyb 39 18 and and CC cord-023726-2fduzqyb 39 19 is be VBZ cord-023726-2fduzqyb 39 20 therefore therefore RB cord-023726-2fduzqyb 39 21 isomorphous isomorphous JJ cord-023726-2fduzqyb 39 22 with with IN cord-023726-2fduzqyb 39 23 it -PRON- PRP cord-023726-2fduzqyb 39 24 in in IN cord-023726-2fduzqyb 39 25 symmetry symmetry NN cord-023726-2fduzqyb 39 26 : : : cord-023726-2fduzqyb 39 27 the the DT cord-023726-2fduzqyb 39 28 dodecahedron dodecahedron NN cord-023726-2fduzqyb 39 29 has have VBZ cord-023726-2fduzqyb 39 30 12 12 CD cord-023726-2fduzqyb 39 31 faces face NNS cord-023726-2fduzqyb 39 32 which which WDT cord-023726-2fduzqyb 39 33 are be VBP cord-023726-2fduzqyb 39 34 regular regular JJ cord-023726-2fduzqyb 39 35 pentagons pentagon NNS cord-023726-2fduzqyb 39 36 , , , cord-023726-2fduzqyb 39 37 20 20 CD cord-023726-2fduzqyb 39 38 vertices vertex NNS cord-023726-2fduzqyb 39 39 where where WRB cord-023726-2fduzqyb 39 40 three three CD cord-023726-2fduzqyb 39 41 faces face NNS cord-023726-2fduzqyb 39 42 meet meet VBP cord-023726-2fduzqyb 39 43 , , , cord-023726-2fduzqyb 39 44 and and CC cord-023726-2fduzqyb 39 45 30 30 CD cord-023726-2fduzqyb 39 46 edges edge NNS cord-023726-2fduzqyb 39 47 with with IN cord-023726-2fduzqyb 39 48 twofold twofold JJ cord-023726-2fduzqyb 39 49 symmetry symmetry NN cord-023726-2fduzqyb 39 50 . . . cord-023726-2fduzqyb 40 1 The the DT cord-023726-2fduzqyb 40 2 three three CD cord-023726-2fduzqyb 40 3 remaining remain VBG cord-023726-2fduzqyb 40 4 regular regular JJ cord-023726-2fduzqyb 40 5 solids solid NNS cord-023726-2fduzqyb 40 6 have have VBP cord-023726-2fduzqyb 40 7 different different JJ cord-023726-2fduzqyb 40 8 symmetry symmetry NN cord-023726-2fduzqyb 40 9 axes axis NNS cord-023726-2fduzqyb 40 10 . . . cord-023726-2fduzqyb 41 1 The the DT cord-023726-2fduzqyb 41 2 vast vast JJ cord-023726-2fduzqyb 41 3 majority majority NN cord-023726-2fduzqyb 41 4 of of IN cord-023726-2fduzqyb 41 5 regular regular JJ cord-023726-2fduzqyb 41 6 viruses virus NNS cord-023726-2fduzqyb 41 7 that that WDT cord-023726-2fduzqyb 41 8 appear appear VBP cord-023726-2fduzqyb 41 9 spherical spherical JJ cord-023726-2fduzqyb 41 10 have have VBP cord-023726-2fduzqyb 41 11 icosahedral icosahedral JJ cord-023726-2fduzqyb 41 12 symmetry symmetry NN cord-023726-2fduzqyb 41 13 . . . cord-023726-2fduzqyb 42 1 In in IN cord-023726-2fduzqyb 42 2 an an DT cord-023726-2fduzqyb 42 3 icosahedron icosahedron NN cord-023726-2fduzqyb 42 4 , , , cord-023726-2fduzqyb 42 5 the the DT cord-023726-2fduzqyb 42 6 smallest small JJS cord-023726-2fduzqyb 42 7 number number NN cord-023726-2fduzqyb 42 8 of of IN cord-023726-2fduzqyb 42 9 subunits subunit NNS cord-023726-2fduzqyb 42 10 that that WDT cord-023726-2fduzqyb 42 11 can can MD cord-023726-2fduzqyb 42 12 form form VB cord-023726-2fduzqyb 42 13 the the DT cord-023726-2fduzqyb 42 14 three three CD cord-023726-2fduzqyb 42 15 - - HYPH cord-023726-2fduzqyb 42 16 dimensional dimensional JJ cord-023726-2fduzqyb 42 17 structure structure NN cord-023726-2fduzqyb 42 18 is be VBZ cord-023726-2fduzqyb 42 19 60 60 CD cord-023726-2fduzqyb 42 20 ( ( -LRB- cord-023726-2fduzqyb 42 21 5 5 CD cord-023726-2fduzqyb 42 22 subunits subunit NNS cord-023726-2fduzqyb 42 23 at at IN cord-023726-2fduzqyb 42 24 each each DT cord-023726-2fduzqyb 42 25 of of IN cord-023726-2fduzqyb 42 26 the the DT cord-023726-2fduzqyb 42 27 12 12 CD cord-023726-2fduzqyb 42 28 vertices vertex NNS cord-023726-2fduzqyb 42 29 , , , cord-023726-2fduzqyb 42 30 or or CC cord-023726-2fduzqyb 42 31 viewed view VBN cord-023726-2fduzqyb 42 32 slightly slightly RB cord-023726-2fduzqyb 42 33 differently differently RB cord-023726-2fduzqyb 42 34 , , , cord-023726-2fduzqyb 42 35 3 3 CD cord-023726-2fduzqyb 42 36 units unit NNS cord-023726-2fduzqyb 42 37 on on IN cord-023726-2fduzqyb 42 38 each each DT cord-023726-2fduzqyb 42 39 of of IN cord-023726-2fduzqyb 42 40 the the DT cord-023726-2fduzqyb 42 41 20 20 CD cord-023726-2fduzqyb 42 42 triangular triangular JJ cord-023726-2fduzqyb 42 43 faces face NNS cord-023726-2fduzqyb 42 44 ) ) -RRB- cord-023726-2fduzqyb 42 45 . . . cord-023726-2fduzqyb 43 1 Some some DT cord-023726-2fduzqyb 43 2 viruses virus NNS cord-023726-2fduzqyb 43 3 do do VBP cord-023726-2fduzqyb 43 4 in in IN cord-023726-2fduzqyb 43 5 fact fact NN cord-023726-2fduzqyb 43 6 use use VB cord-023726-2fduzqyb 43 7 60 60 CD cord-023726-2fduzqyb 43 8 subunits subunit NNS cord-023726-2fduzqyb 43 9 , , , cord-023726-2fduzqyb 43 10 but but CC cord-023726-2fduzqyb 43 11 most most JJS cord-023726-2fduzqyb 43 12 use use VBP cord-023726-2fduzqyb 43 13 more more JJR cord-023726-2fduzqyb 43 14 subunits subunit NNS cord-023726-2fduzqyb 43 15 in in IN cord-023726-2fduzqyb 43 16 order order NN cord-023726-2fduzqyb 43 17 to to TO cord-023726-2fduzqyb 43 18 provide provide VB cord-023726-2fduzqyb 43 19 a a DT cord-023726-2fduzqyb 43 20 larger large JJR cord-023726-2fduzqyb 43 21 shell shell NN cord-023726-2fduzqyb 43 22 capable capable JJ cord-023726-2fduzqyb 43 23 of of IN cord-023726-2fduzqyb 43 24 holding hold VBG cord-023726-2fduzqyb 43 25 more more RBR cord-023726-2fduzqyb 43 26 nucleic nucleic JJ cord-023726-2fduzqyb 43 27 acid acid NN cord-023726-2fduzqyb 43 28 . . . cord-023726-2fduzqyb 44 1 The the DT cord-023726-2fduzqyb 44 2 number number NN cord-023726-2fduzqyb 44 3 of of IN cord-023726-2fduzqyb 44 4 subunits subunit NNS cord-023726-2fduzqyb 44 5 in in IN cord-023726-2fduzqyb 44 6 an an DT cord-023726-2fduzqyb 44 7 icosahedral icosahedral JJ cord-023726-2fduzqyb 44 8 structure structure NN cord-023726-2fduzqyb 44 9 is be VBZ cord-023726-2fduzqyb 44 10 60 60 CD cord-023726-2fduzqyb 44 11 T t NN cord-023726-2fduzqyb 44 12 , , , cord-023726-2fduzqyb 44 13 where where WRB cord-023726-2fduzqyb 44 14 the the DT cord-023726-2fduzqyb 44 15 permissible permissible JJ cord-023726-2fduzqyb 44 16 values value NNS cord-023726-2fduzqyb 44 17 of of IN cord-023726-2fduzqyb 44 18 T T NNP cord-023726-2fduzqyb 44 19 are be VBP cord-023726-2fduzqyb 44 20 given give VBN cord-023726-2fduzqyb 44 21 by by IN cord-023726-2fduzqyb 44 22 T t NN cord-023726-2fduzqyb 44 23 = = NN cord-023726-2fduzqyb 45 1 H h NN cord-023726-2fduzqyb 45 2 2 2 CD cord-023726-2fduzqyb 46 1 + + CC cord-023726-2fduzqyb 47 1 HK HK NNP cord-023726-2fduzqyb 47 2 + + CC cord-023726-2fduzqyb 47 3 K K NNP cord-023726-2fduzqyb 47 4 2 2 CD cord-023726-2fduzqyb 47 5 , , , cord-023726-2fduzqyb 47 6 where where WRB cord-023726-2fduzqyb 47 7 H H NNP cord-023726-2fduzqyb 47 8 and and CC cord-023726-2fduzqyb 47 9 K K NNP cord-023726-2fduzqyb 47 10 are be VBP cord-023726-2fduzqyb 47 11 integers integer NNS cord-023726-2fduzqyb 47 12 and and CC cord-023726-2fduzqyb 47 13 T T NNP cord-023726-2fduzqyb 47 14 is be VBZ cord-023726-2fduzqyb 47 15 called call VBN cord-023726-2fduzqyb 47 16 the the DT cord-023726-2fduzqyb 47 17 triangulation triangulation NN cord-023726-2fduzqyb 47 18 number number NN cord-023726-2fduzqyb 47 19 . . . cord-023726-2fduzqyb 48 1 Permissible permissible JJ cord-023726-2fduzqyb 48 2 triangulation triangulation NN cord-023726-2fduzqyb 48 3 numbers number NNS cord-023726-2fduzqyb 48 4 are be VBP cord-023726-2fduzqyb 48 5 1 1 CD cord-023726-2fduzqyb 48 6 , , , cord-023726-2fduzqyb 48 7 3 3 CD cord-023726-2fduzqyb 48 8 , , , cord-023726-2fduzqyb 48 9 4 4 CD cord-023726-2fduzqyb 48 10 , , , cord-023726-2fduzqyb 48 11 7 7 CD cord-023726-2fduzqyb 48 12 , , , cord-023726-2fduzqyb 48 13 9 9 CD cord-023726-2fduzqyb 48 14 , , , cord-023726-2fduzqyb 48 15 12 12 CD cord-023726-2fduzqyb 48 16 , , , cord-023726-2fduzqyb 48 17 13 13 CD cord-023726-2fduzqyb 48 18 , , , cord-023726-2fduzqyb 48 19 16 16 CD cord-023726-2fduzqyb 48 20 , , , cord-023726-2fduzqyb 48 21 and and CC cord-023726-2fduzqyb 48 22 so so RB cord-023726-2fduzqyb 48 23 forth forth RB cord-023726-2fduzqyb 48 24 . . . cord-023726-2fduzqyb 49 1 A a DT cord-023726-2fduzqyb 49 2 subunit subunit NN cord-023726-2fduzqyb 49 3 defined define VBN cord-023726-2fduzqyb 49 4 in in IN cord-023726-2fduzqyb 49 5 this this DT cord-023726-2fduzqyb 49 6 way way NN cord-023726-2fduzqyb 49 7 is be VBZ cord-023726-2fduzqyb 49 8 not not RB cord-023726-2fduzqyb 49 9 necessarily necessarily RB cord-023726-2fduzqyb 49 10 formed form VBN cord-023726-2fduzqyb 49 11 by by IN cord-023726-2fduzqyb 49 12 one one CD cord-023726-2fduzqyb 49 13 protein protein NN cord-023726-2fduzqyb 49 14 molecule molecule NN cord-023726-2fduzqyb 49 15 , , , cord-023726-2fduzqyb 49 16 although although IN cord-023726-2fduzqyb 49 17 in in IN cord-023726-2fduzqyb 49 18 most most JJS cord-023726-2fduzqyb 49 19 cases case NNS cord-023726-2fduzqyb 49 20 this this DT cord-023726-2fduzqyb 49 21 is be VBZ cord-023726-2fduzqyb 49 22 how how WRB cord-023726-2fduzqyb 49 23 a a DT cord-023726-2fduzqyb 49 24 structural structural JJ cord-023726-2fduzqyb 49 25 subunit subunit NN cord-023726-2fduzqyb 49 26 is be VBZ cord-023726-2fduzqyb 49 27 in in IN cord-023726-2fduzqyb 49 28 fact fact NN cord-023726-2fduzqyb 49 29 formed form VBN cord-023726-2fduzqyb 49 30 . . . cord-023726-2fduzqyb 50 1 Some some DT cord-023726-2fduzqyb 50 2 viruses virus NNS cord-023726-2fduzqyb 50 3 that that WDT cord-023726-2fduzqyb 50 4 form form VBP cord-023726-2fduzqyb 50 5 regular regular JJ cord-023726-2fduzqyb 50 6 structures structure NNS cord-023726-2fduzqyb 50 7 that that WDT cord-023726-2fduzqyb 50 8 are be VBP cord-023726-2fduzqyb 50 9 constructed construct VBN cord-023726-2fduzqyb 50 10 using use VBG cord-023726-2fduzqyb 50 11 icosahedral icosahedral JJ cord-023726-2fduzqyb 50 12 symmetry symmetry NN cord-023726-2fduzqyb 50 13 principles principle NNS cord-023726-2fduzqyb 50 14 do do VBP cord-023726-2fduzqyb 50 15 not not RB cord-023726-2fduzqyb 50 16 possess possess VB cord-023726-2fduzqyb 50 17 true true JJ cord-023726-2fduzqyb 50 18 icosahedral icosahedral JJ cord-023726-2fduzqyb 50 19 symmetry symmetry NN cord-023726-2fduzqyb 50 20 . . . cord-023726-2fduzqyb 51 1 In in IN cord-023726-2fduzqyb 51 2 such such JJ cord-023726-2fduzqyb 51 3 cases case NNS cord-023726-2fduzqyb 51 4 they -PRON- PRP cord-023726-2fduzqyb 51 5 are be VBP cord-023726-2fduzqyb 51 6 said say VBN cord-023726-2fduzqyb 51 7 to to TO cord-023726-2fduzqyb 51 8 have have VB cord-023726-2fduzqyb 51 9 pseudo pseudo JJ cord-023726-2fduzqyb 51 10 - - JJ cord-023726-2fduzqyb 51 11 triangulation triangulation JJ cord-023726-2fduzqyb 51 12 numbers number NNS cord-023726-2fduzqyb 51 13 . . . cord-023726-2fduzqyb 52 1 Examples example NNS cord-023726-2fduzqyb 52 2 are be VBP cord-023726-2fduzqyb 52 3 described describe VBN cord-023726-2fduzqyb 52 4 later later RB cord-023726-2fduzqyb 52 5 . . . cord-023726-2fduzqyb 53 1 a a DT cord-023726-2fduzqyb 53 2 protein protein NN cord-023726-2fduzqyb 53 3 subunit subunit NN cord-023726-2fduzqyb 53 4 , , , cord-023726-2fduzqyb 53 5 shown show VBN cord-023726-2fduzqyb 53 6 as as IN cord-023726-2fduzqyb 53 7 blue blue JJ cord-023726-2fduzqyb 53 8 trapezoids trapezoid NNS cord-023726-2fduzqyb 53 9 labeled label VBN cord-023726-2fduzqyb 53 10 " " `` cord-023726-2fduzqyb 53 11 A. a. NN cord-023726-2fduzqyb 53 12 " " '' cord-023726-2fduzqyb 54 1 The the DT cord-023726-2fduzqyb 54 2 twofold twofold NN cord-023726-2fduzqyb 54 3 , , , cord-023726-2fduzqyb 54 4 threefold threefold JJ cord-023726-2fduzqyb 54 5 , , , cord-023726-2fduzqyb 54 6 and and CC cord-023726-2fduzqyb 54 7 fivefold fivefold JJ cord-023726-2fduzqyb 54 8 axes axis NNS cord-023726-2fduzqyb 54 9 of of IN cord-023726-2fduzqyb 54 10 symmetry symmetry NN cord-023726-2fduzqyb 54 11 are be VBP cord-023726-2fduzqyb 54 12 shown show VBN cord-023726-2fduzqyb 54 13 in in IN cord-023726-2fduzqyb 54 14 yellow yellow JJ cord-023726-2fduzqyb 54 15 . . . cord-023726-2fduzqyb 55 1 This this DT cord-023726-2fduzqyb 55 2 is be VBZ cord-023726-2fduzqyb 55 3 the the DT cord-023726-2fduzqyb 55 4 largest large JJS cord-023726-2fduzqyb 55 5 assembly assembly NN cord-023726-2fduzqyb 55 6 in in IN cord-023726-2fduzqyb 55 7 which which WDT cord-023726-2fduzqyb 55 8 every every DT cord-023726-2fduzqyb 55 9 subunit subunit NN cord-023726-2fduzqyb 55 10 is be VBZ cord-023726-2fduzqyb 55 11 in in IN cord-023726-2fduzqyb 55 12 an an DT cord-023726-2fduzqyb 55 13 identical identical JJ cord-023726-2fduzqyb 55 14 environment environment NN cord-023726-2fduzqyb 55 15 . . . cord-023726-2fduzqyb 56 1 ( ( -LRB- cord-023726-2fduzqyb 56 2 B b NN cord-023726-2fduzqyb 56 3 ) ) -RRB- cord-023726-2fduzqyb 56 4 Schematic schematic JJ cord-023726-2fduzqyb 56 5 representation representation NN cord-023726-2fduzqyb 56 6 of of IN cord-023726-2fduzqyb 56 7 the the DT cord-023726-2fduzqyb 56 8 subunit subunit NN cord-023726-2fduzqyb 56 9 building building NN cord-023726-2fduzqyb 56 10 block block NN cord-023726-2fduzqyb 56 11 found find VBN cord-023726-2fduzqyb 56 12 in in IN cord-023726-2fduzqyb 56 13 many many JJ cord-023726-2fduzqyb 56 14 RNA RNA NNP cord-023726-2fduzqyb 56 15 viruses virus NNS cord-023726-2fduzqyb 56 16 , , , cord-023726-2fduzqyb 56 17 known know VBN cord-023726-2fduzqyb 56 18 as as IN cord-023726-2fduzqyb 56 19 the the DT cord-023726-2fduzqyb 56 20 eightfold eightfold JJ cord-023726-2fduzqyb 56 21 β β XX cord-023726-2fduzqyb 56 22 barrel barrel NN cord-023726-2fduzqyb 56 23 or or CC cord-023726-2fduzqyb 56 24 β β NN cord-023726-2fduzqyb 56 25 sandwich sandwich NN cord-023726-2fduzqyb 56 26 . . . cord-023726-2fduzqyb 57 1 The the DT cord-023726-2fduzqyb 57 2 β β NN cord-023726-2fduzqyb 57 3 sheets sheet NNS cord-023726-2fduzqyb 57 4 , , , cord-023726-2fduzqyb 57 5 labeled label VBN cord-023726-2fduzqyb 57 6 B b NN cord-023726-2fduzqyb 57 7 through through IN cord-023726-2fduzqyb 57 8 I -PRON- PRP cord-023726-2fduzqyb 57 9 from from IN cord-023726-2fduzqyb 57 10 the the DT cord-023726-2fduzqyb 57 11 N n CD cord-023726-2fduzqyb 57 12 terminus terminus NN cord-023726-2fduzqyb 57 13 of of IN cord-023726-2fduzqyb 57 14 the the DT cord-023726-2fduzqyb 57 15 protein protein NN cord-023726-2fduzqyb 57 16 , , , cord-023726-2fduzqyb 57 17 are be VBP cord-023726-2fduzqyb 57 18 shown show VBN cord-023726-2fduzqyb 57 19 as as IN cord-023726-2fduzqyb 57 20 yellow yellow JJ cord-023726-2fduzqyb 57 21 and and CC cord-023726-2fduzqyb 57 22 red red JJ cord-023726-2fduzqyb 57 23 arrows arrow NNS cord-023726-2fduzqyb 57 24 ; ; : cord-023726-2fduzqyb 57 25 two two CD cord-023726-2fduzqyb 57 26 possible possible JJ cord-023726-2fduzqyb 57 27 α α NN cord-023726-2fduzqyb 57 28 helices helix NNS cord-023726-2fduzqyb 57 29 joining join VBG cord-023726-2fduzqyb 57 30 these these DT cord-023726-2fduzqyb 57 31 sheets sheet NNS cord-023726-2fduzqyb 57 32 are be VBP cord-023726-2fduzqyb 57 33 shown show VBN cord-023726-2fduzqyb 57 34 in in IN cord-023726-2fduzqyb 57 35 green green JJ cord-023726-2fduzqyb 57 36 . . . cord-023726-2fduzqyb 58 1 Some some DT cord-023726-2fduzqyb 58 2 proteins protein NNS cord-023726-2fduzqyb 58 3 have have VBP cord-023726-2fduzqyb 58 4 insertions insertion NNS cord-023726-2fduzqyb 58 5 in in IN cord-023726-2fduzqyb 58 6 the the DT cord-023726-2fduzqyb 58 7 C C NNP cord-023726-2fduzqyb 58 8 - - HYPH cord-023726-2fduzqyb 58 9 D D NNP cord-023726-2fduzqyb 58 10 , , , cord-023726-2fduzqyb 58 11 E E NNP cord-023726-2fduzqyb 58 12 - - HYPH cord-023726-2fduzqyb 58 13 F F NNP cord-023726-2fduzqyb 58 14 , , , cord-023726-2fduzqyb 58 15 and and CC cord-023726-2fduzqyb 58 16 G g NN cord-023726-2fduzqyb 58 17 - - HYPH cord-023726-2fduzqyb 58 18 H h NN cord-023726-2fduzqyb 58 19 loops loop NNS cord-023726-2fduzqyb 58 20 , , , cord-023726-2fduzqyb 58 21 but but CC cord-023726-2fduzqyb 58 22 insertions insertion NNS cord-023726-2fduzqyb 58 23 are be VBP cord-023726-2fduzqyb 58 24 uncommon uncommon JJ cord-023726-2fduzqyb 58 25 at at IN cord-023726-2fduzqyb 58 26 the the DT cord-023726-2fduzqyb 58 27 narrow narrow JJ cord-023726-2fduzqyb 58 28 end end NN cord-023726-2fduzqyb 58 29 of of IN cord-023726-2fduzqyb 58 30 the the DT cord-023726-2fduzqyb 58 31 wedge wedge NN cord-023726-2fduzqyb 58 32 ( ( -LRB- cord-023726-2fduzqyb 58 33 at at IN cord-023726-2fduzqyb 58 34 the the DT cord-023726-2fduzqyb 58 35 fivefold fivefold JJ cord-023726-2fduzqyb 58 36 axis axis NN cord-023726-2fduzqyb 58 37 ) ) -RRB- cord-023726-2fduzqyb 58 38 . . . cord-023726-2fduzqyb 59 1 From from IN cord-023726-2fduzqyb 59 2 Granoff Granoff NNP cord-023726-2fduzqyb 59 3 and and CC cord-023726-2fduzqyb 59 4 Webster Webster NNP cord-023726-2fduzqyb 59 5 ( ( -LRB- cord-023726-2fduzqyb 59 6 1999 1999 CD cord-023726-2fduzqyb 59 7 ) ) -RRB- cord-023726-2fduzqyb 59 8 Vol Vol NNP cord-023726-2fduzqyb 59 9 . . . cord-023726-2fduzqyb 60 1 3 3 LS cord-023726-2fduzqyb 60 2 , , , cord-023726-2fduzqyb 60 3 color color NN cord-023726-2fduzqyb 60 4 plate plate NN cord-023726-2fduzqyb 60 5 31 31 CD cord-023726-2fduzqyb 60 6 . . . cord-023726-2fduzqyb 61 1 [ [ -LRB- cord-023726-2fduzqyb 61 2 Originally originally RB cord-023726-2fduzqyb 61 3 from from IN cord-023726-2fduzqyb 61 4 J. J. NNP cord-023726-2fduzqyb 61 5 Johnson Johnson NNP cord-023726-2fduzqyb 61 6 ( ( -LRB- cord-023726-2fduzqyb 61 7 1996 1996 CD cord-023726-2fduzqyb 61 8 ) ) -RRB- cord-023726-2fduzqyb 61 9 ] ] -RRB- cord-023726-2fduzqyb 61 10 . . . cord-023726-2fduzqyb 62 1 Structural structural JJ cord-023726-2fduzqyb 62 2 studies study NNS cord-023726-2fduzqyb 62 3 of of IN cord-023726-2fduzqyb 62 4 viruses virus NNS cord-023726-2fduzqyb 62 5 have have VBP cord-023726-2fduzqyb 62 6 shown show VBN cord-023726-2fduzqyb 62 7 that that IN cord-023726-2fduzqyb 62 8 the the DT cord-023726-2fduzqyb 62 9 capsid capsid NN cord-023726-2fduzqyb 62 10 proteins protein NNS cord-023726-2fduzqyb 62 11 that that WDT cord-023726-2fduzqyb 62 12 form form VBP cord-023726-2fduzqyb 62 13 the the DT cord-023726-2fduzqyb 62 14 virions virion NNS cord-023726-2fduzqyb 62 15 of of IN cord-023726-2fduzqyb 62 16 many many JJ cord-023726-2fduzqyb 62 17 plant plant NN cord-023726-2fduzqyb 62 18 and and CC cord-023726-2fduzqyb 62 19 animal animal NN cord-023726-2fduzqyb 62 20 icosahedral icosahedral JJ cord-023726-2fduzqyb 62 21 viruses virus NNS cord-023726-2fduzqyb 62 22 have have VBP cord-023726-2fduzqyb 62 23 a a DT cord-023726-2fduzqyb 62 24 common common JJ cord-023726-2fduzqyb 62 25 fold fold NN cord-023726-2fduzqyb 62 26 . . . cord-023726-2fduzqyb 63 1 This this DT cord-023726-2fduzqyb 63 2 fold fold NN cord-023726-2fduzqyb 63 3 , , , cord-023726-2fduzqyb 63 4 an an DT cord-023726-2fduzqyb 63 5 eightstranded eightstrande VBN cord-023726-2fduzqyb 63 6 antiparallel antiparallel IN cord-023726-2fduzqyb 63 7 β β NN cord-023726-2fduzqyb 63 8 sandwich sandwich NN cord-023726-2fduzqyb 63 9 , , , cord-023726-2fduzqyb 63 10 is be VBZ cord-023726-2fduzqyb 63 11 illustrated illustrate VBN cord-023726-2fduzqyb 63 12 in in IN cord-023726-2fduzqyb 63 13 Fig Fig NNP cord-023726-2fduzqyb 63 14 . . . cord-023726-2fduzqyb 63 15 2.3B 2.3B NNP cord-023726-2fduzqyb 63 16 . . . cord-023726-2fduzqyb 64 1 The the DT cord-023726-2fduzqyb 64 2 presence presence NN cord-023726-2fduzqyb 64 3 of of IN cord-023726-2fduzqyb 64 4 a a DT cord-023726-2fduzqyb 64 5 common common JJ cord-023726-2fduzqyb 64 6 fold fold NN cord-023726-2fduzqyb 64 7 suggests suggest VBZ cord-023726-2fduzqyb 64 8 that that IN cord-023726-2fduzqyb 64 9 these these DT cord-023726-2fduzqyb 64 10 capsid capsid NN cord-023726-2fduzqyb 64 11 proteins protein NNS cord-023726-2fduzqyb 64 12 have have VBP cord-023726-2fduzqyb 64 13 a a DT cord-023726-2fduzqyb 64 14 common common JJ cord-023726-2fduzqyb 64 15 origin origin NN cord-023726-2fduzqyb 64 16 even even RB cord-023726-2fduzqyb 64 17 if if IN cord-023726-2fduzqyb 64 18 no no DT cord-023726-2fduzqyb 64 19 sequence sequence NN cord-023726-2fduzqyb 64 20 identity identity NN cord-023726-2fduzqyb 64 21 is be VBZ cord-023726-2fduzqyb 64 22 detectable detectable JJ cord-023726-2fduzqyb 64 23 . . . cord-023726-2fduzqyb 65 1 The the DT cord-023726-2fduzqyb 65 2 divergence divergence NN cord-023726-2fduzqyb 65 3 in in IN cord-023726-2fduzqyb 65 4 sequence sequence NN cord-023726-2fduzqyb 65 5 while while IN cord-023726-2fduzqyb 65 6 maintaining maintain VBG cord-023726-2fduzqyb 65 7 this this DT cord-023726-2fduzqyb 65 8 basic basic JJ cord-023726-2fduzqyb 65 9 fold fold NN cord-023726-2fduzqyb 65 10 is be VBZ cord-023726-2fduzqyb 65 11 illustrated illustrate VBN cord-023726-2fduzqyb 65 12 in in IN cord-023726-2fduzqyb 65 13 Fig Fig NNP cord-023726-2fduzqyb 65 14 . . . cord-023726-2fduzqyb 66 1 2 2 LS cord-023726-2fduzqyb 66 2 .4 .4 CD cord-023726-2fduzqyb 66 3 , , , cord-023726-2fduzqyb 66 4 where where WRB cord-023726-2fduzqyb 66 5 capsid capsid NN cord-023726-2fduzqyb 66 6 proteins protein NNS cord-023726-2fduzqyb 66 7 of of IN cord-023726-2fduzqyb 66 8 three three CD cord-023726-2fduzqyb 66 9 viruses virus NNS cord-023726-2fduzqyb 66 10 are be VBP cord-023726-2fduzqyb 66 11 shown show VBN cord-023726-2fduzqyb 66 12 . . . cord-023726-2fduzqyb 67 1 SV40 SV40 NNP cord-023726-2fduzqyb 67 2 ( ( -LRB- cord-023726-2fduzqyb 67 3 family family NN cord-023726-2fduzqyb 67 4 Polyomaviridae Polyomaviridae NNP cord-023726-2fduzqyb 67 5 ) ) -RRB- cord-023726-2fduzqyb 67 6 , , , cord-023726-2fduzqyb 67 7 poliovirus poliovirus NN cord-023726-2fduzqyb 67 8 ( ( -LRB- cord-023726-2fduzqyb 67 9 family family NN cord-023726-2fduzqyb 67 10 Picornaviridae Picornaviridae NNP cord-023726-2fduzqyb 67 11 ) ) -RRB- cord-023726-2fduzqyb 67 12 , , , cord-023726-2fduzqyb 67 13 and and CC cord-023726-2fduzqyb 67 14 bluetongue bluetongue NN cord-023726-2fduzqyb 67 15 virus virus NN cord-023726-2fduzqyb 67 16 ( ( -LRB- cord-023726-2fduzqyb 67 17 family family NN cord-023726-2fduzqyb 67 18 Reoviridae Reoviridae NNP cord-023726-2fduzqyb 67 19 ) ) -RRB- cord-023726-2fduzqyb 67 20 are be VBP cord-023726-2fduzqyb 67 21 a a DT cord-023726-2fduzqyb 67 22 DNA dna NN cord-023726-2fduzqyb 67 23 virus virus NN cord-023726-2fduzqyb 67 24 , , , cord-023726-2fduzqyb 67 25 a a DT cord-023726-2fduzqyb 67 26 single single JJ cord-023726-2fduzqyb 67 27 - - HYPH cord-023726-2fduzqyb 67 28 strand strand NN cord-023726-2fduzqyb 67 29 RNA RNA NNP cord-023726-2fduzqyb 67 30 virus virus NN cord-023726-2fduzqyb 67 31 , , , cord-023726-2fduzqyb 67 32 and and CC cord-023726-2fduzqyb 67 33 a a DT cord-023726-2fduzqyb 67 34 double double JJ cord-023726-2fduzqyb 67 35 - - HYPH cord-023726-2fduzqyb 67 36 strand strand NN cord-023726-2fduzqyb 67 37 RNA RNA NNP cord-023726-2fduzqyb 67 38 virus virus NN cord-023726-2fduzqyb 67 39 , , , cord-023726-2fduzqyb 67 40 respectively respectively RB cord-023726-2fduzqyb 67 41 . . . cord-023726-2fduzqyb 68 1 Their -PRON- PRP$ cord-023726-2fduzqyb 68 2 capsid capsid NN cord-023726-2fduzqyb 68 3 proteins protein NNS cord-023726-2fduzqyb 68 4 have have VBP cord-023726-2fduzqyb 68 5 insertions insertion NNS cord-023726-2fduzqyb 68 6 into into IN cord-023726-2fduzqyb 68 7 the the DT cord-023726-2fduzqyb 68 8 basic basic JJ cord-023726-2fduzqyb 68 9 eight eight CD cord-023726-2fduzqyb 68 10 - - HYPH cord-023726-2fduzqyb 68 11 stranded stranded JJ cord-023726-2fduzqyb 68 12 antiparallel antiparallel IN cord-023726-2fduzqyb 68 13 β β NN cord-023726-2fduzqyb 68 14 - - HYPH cord-023726-2fduzqyb 68 15 sandwich sandwich NN cord-023726-2fduzqyb 68 16 structure structure NN cord-023726-2fduzqyb 68 17 that that WDT cord-023726-2fduzqyb 68 18 serve serve VBP cord-023726-2fduzqyb 68 19 important important JJ cord-023726-2fduzqyb 68 20 functions function NNS cord-023726-2fduzqyb 68 21 in in IN cord-023726-2fduzqyb 68 22 virus virus NN cord-023726-2fduzqyb 68 23 assembly assembly NN cord-023726-2fduzqyb 68 24 . . . cord-023726-2fduzqyb 69 1 However however RB cord-023726-2fduzqyb 69 2 , , , cord-023726-2fduzqyb 69 3 they -PRON- PRP cord-023726-2fduzqyb 69 4 all all DT cord-023726-2fduzqyb 69 5 possess possess VBP cord-023726-2fduzqyb 69 6 a a DT cord-023726-2fduzqyb 69 7 region region NN cord-023726-2fduzqyb 69 8 exhibiting exhibit VBG cord-023726-2fduzqyb 69 9 the the DT cord-023726-2fduzqyb 69 10 common common JJ cord-023726-2fduzqyb 69 11 β β NN cord-023726-2fduzqyb 69 12 - - HYPH cord-023726-2fduzqyb 69 13 sandwich sandwich NN cord-023726-2fduzqyb 69 14 fold fold NN cord-023726-2fduzqyb 69 15 and and CC cord-023726-2fduzqyb 69 16 may may MD cord-023726-2fduzqyb 69 17 have have VB cord-023726-2fduzqyb 69 18 originated originate VBN cord-023726-2fduzqyb 69 19 from from IN cord-023726-2fduzqyb 69 20 a a DT cord-023726-2fduzqyb 69 21 common common JJ cord-023726-2fduzqyb 69 22 ancestral ancestral JJ cord-023726-2fduzqyb 69 23 protein protein NN cord-023726-2fduzqyb 69 24 . . . cord-023726-2fduzqyb 70 1 Thus thus RB cord-023726-2fduzqyb 70 2 , , , cord-023726-2fduzqyb 70 3 once once RB cord-023726-2fduzqyb 70 4 a a DT cord-023726-2fduzqyb 70 5 suitable suitable JJ cord-023726-2fduzqyb 70 6 capsid capsid NN cord-023726-2fduzqyb 70 7 protein protein NN cord-023726-2fduzqyb 70 8 arose arise VBD cord-023726-2fduzqyb 70 9 that that DT cord-023726-2fduzqyb 70 10 could could MD cord-023726-2fduzqyb 70 11 be be VB cord-023726-2fduzqyb 70 12 used use VBN cord-023726-2fduzqyb 70 13 to to TO cord-023726-2fduzqyb 70 14 construct construct VB cord-023726-2fduzqyb 70 15 simple simple JJ cord-023726-2fduzqyb 70 16 icosahedral icosahedral JJ cord-023726-2fduzqyb 70 17 particles particle NNS cord-023726-2fduzqyb 70 18 , , , cord-023726-2fduzqyb 70 19 it -PRON- PRP cord-023726-2fduzqyb 70 20 may may MD cord-023726-2fduzqyb 70 21 ultimately ultimately RB cord-023726-2fduzqyb 70 22 have have VB cord-023726-2fduzqyb 70 23 been be VBN cord-023726-2fduzqyb 70 24 acquired acquire VBN cord-023726-2fduzqyb 70 25 by by IN cord-023726-2fduzqyb 70 26 many many JJ cord-023726-2fduzqyb 70 27 viruses virus NNS cord-023726-2fduzqyb 70 28 . . . cord-023726-2fduzqyb 71 1 The the DT cord-023726-2fduzqyb 71 2 viruses virus NNS cord-023726-2fduzqyb 71 3 that that WDT cord-023726-2fduzqyb 71 4 possess possess VBP cord-023726-2fduzqyb 71 5 capsid capsid NN cord-023726-2fduzqyb 71 6 proteins protein NNS cord-023726-2fduzqyb 71 7 with with IN cord-023726-2fduzqyb 71 8 this this DT cord-023726-2fduzqyb 71 9 fold fold NN cord-023726-2fduzqyb 71 10 may may MD cord-023726-2fduzqyb 71 11 be be VB cord-023726-2fduzqyb 71 12 related relate VBN cord-023726-2fduzqyb 71 13 by by IN cord-023726-2fduzqyb 71 14 descent descent NN cord-023726-2fduzqyb 71 15 from from IN cord-023726-2fduzqyb 71 16 common common JJ cord-023726-2fduzqyb 71 17 ancestral ancestral JJ cord-023726-2fduzqyb 71 18 viruses virus NNS cord-023726-2fduzqyb 71 19 , , , cord-023726-2fduzqyb 71 20 or or CC cord-023726-2fduzqyb 71 21 recombination recombination NN cord-023726-2fduzqyb 71 22 may may MD cord-023726-2fduzqyb 71 23 have have VB cord-023726-2fduzqyb 71 24 resulted result VBN cord-023726-2fduzqyb 71 25 in in IN cord-023726-2fduzqyb 71 26 the the DT cord-023726-2fduzqyb 71 27 incorporation incorporation NN cord-023726-2fduzqyb 71 28 of of IN cord-023726-2fduzqyb 71 29 this this DT cord-023726-2fduzqyb 71 30 successful successful JJ cord-023726-2fduzqyb 71 31 ancestral ancestral JJ cord-023726-2fduzqyb 71 32 capsid capsid NN cord-023726-2fduzqyb 71 33 protein protein NN cord-023726-2fduzqyb 71 34 into into IN cord-023726-2fduzqyb 71 35 many many JJ cord-023726-2fduzqyb 71 36 lines line NNS cord-023726-2fduzqyb 71 37 of of IN cord-023726-2fduzqyb 71 38 viruses virus NNS cord-023726-2fduzqyb 71 39 . . . cord-023726-2fduzqyb 72 1 Because because IN cord-023726-2fduzqyb 72 2 the the DT cord-023726-2fduzqyb 72 3 size size NN cord-023726-2fduzqyb 72 4 of of IN cord-023726-2fduzqyb 72 5 the the DT cord-023726-2fduzqyb 72 6 icosahedral icosahedral JJ cord-023726-2fduzqyb 72 7 shell shell NN cord-023726-2fduzqyb 72 8 is be VBZ cord-023726-2fduzqyb 72 9 fixed fix VBN cord-023726-2fduzqyb 72 10 by by IN cord-023726-2fduzqyb 72 11 geometric geometric JJ cord-023726-2fduzqyb 72 12 constraints constraint NNS cord-023726-2fduzqyb 72 13 , , , cord-023726-2fduzqyb 72 14 it -PRON- PRP cord-023726-2fduzqyb 72 15 is be VBZ cord-023726-2fduzqyb 72 16 difficult difficult JJ cord-023726-2fduzqyb 72 17 for for IN cord-023726-2fduzqyb 72 18 a a DT cord-023726-2fduzqyb 72 19 change change NN cord-023726-2fduzqyb 72 20 in in IN cord-023726-2fduzqyb 72 21 the the DT cord-023726-2fduzqyb 72 22 size size NN cord-023726-2fduzqyb 72 23 of of IN cord-023726-2fduzqyb 72 24 a a DT cord-023726-2fduzqyb 72 25 viral viral JJ cord-023726-2fduzqyb 72 26 genome genome NN cord-023726-2fduzqyb 72 27 to to TO cord-023726-2fduzqyb 72 28 occur occur VB cord-023726-2fduzqyb 72 29 . . . cord-023726-2fduzqyb 73 1 A a DT cord-023726-2fduzqyb 73 2 change change NN cord-023726-2fduzqyb 73 3 in in IN cord-023726-2fduzqyb 73 4 size size NN cord-023726-2fduzqyb 73 5 will will MD cord-023726-2fduzqyb 73 6 require require VB cord-023726-2fduzqyb 73 7 a a DT cord-023726-2fduzqyb 73 8 change change NN cord-023726-2fduzqyb 73 9 in in IN cord-023726-2fduzqyb 73 10 the the DT cord-023726-2fduzqyb 73 11 triangulation triangulation NN cord-023726-2fduzqyb 73 12 number number NN cord-023726-2fduzqyb 73 13 or or CC cord-023726-2fduzqyb 73 14 changes change NNS cord-023726-2fduzqyb 73 15 in in IN cord-023726-2fduzqyb 73 16 the the DT cord-023726-2fduzqyb 73 17 capsid capsid NN cord-023726-2fduzqyb 73 18 proteins protein NNS cord-023726-2fduzqyb 73 19 sufficient sufficient JJ cord-023726-2fduzqyb 73 20 to to TO cord-023726-2fduzqyb 73 21 produce produce VB cord-023726-2fduzqyb 73 22 a a DT cord-023726-2fduzqyb 73 23 larger large JJR cord-023726-2fduzqyb 73 24 or or CC cord-023726-2fduzqyb 73 25 smaller small JJR cord-023726-2fduzqyb 73 26 internal internal JJ cord-023726-2fduzqyb 73 27 volume volume NN cord-023726-2fduzqyb 73 28 . . . cord-023726-2fduzqyb 74 1 In in IN cord-023726-2fduzqyb 74 2 either either DT cord-023726-2fduzqyb 74 3 case case NN cord-023726-2fduzqyb 74 4 , , , cord-023726-2fduzqyb 74 5 the the DT cord-023726-2fduzqyb 74 6 changes change NNS cord-023726-2fduzqyb 74 7 in in IN cord-023726-2fduzqyb 74 8 the the DT cord-023726-2fduzqyb 74 9 capsid capsid NN cord-023726-2fduzqyb 74 10 proteins protein NNS cord-023726-2fduzqyb 74 11 required require VBN cord-023726-2fduzqyb 74 12 are be VBP cord-023726-2fduzqyb 74 13 relatively relatively RB cord-023726-2fduzqyb 74 14 slow slow JJ cord-023726-2fduzqyb 74 15 to to TO cord-023726-2fduzqyb 74 16 occur occur VB cord-023726-2fduzqyb 74 17 on on IN cord-023726-2fduzqyb 74 18 an an DT cord-023726-2fduzqyb 74 19 evolutionary evolutionary JJ cord-023726-2fduzqyb 74 20 timescale timescale NN cord-023726-2fduzqyb 74 21 and and CC cord-023726-2fduzqyb 74 22 the the DT cord-023726-2fduzqyb 74 23 size size NN cord-023726-2fduzqyb 74 24 of of IN cord-023726-2fduzqyb 74 25 an an DT cord-023726-2fduzqyb 74 26 icosahedral icosahedral JJ cord-023726-2fduzqyb 74 27 virus virus NN cord-023726-2fduzqyb 74 28 is be VBZ cord-023726-2fduzqyb 74 29 " " `` cord-023726-2fduzqyb 74 30 frozen frozen JJ cord-023726-2fduzqyb 74 31 " " '' cord-023726-2fduzqyb 74 32 for for IN cord-023726-2fduzqyb 74 33 long long JJ cord-023726-2fduzqyb 74 34 periods period NNS cord-023726-2fduzqyb 74 35 of of IN cord-023726-2fduzqyb 74 36 evolutionary evolutionary JJ cord-023726-2fduzqyb 74 37 time time NN cord-023726-2fduzqyb 74 38 . . . cord-023726-2fduzqyb 75 1 For for IN cord-023726-2fduzqyb 75 2 this this DT cord-023726-2fduzqyb 75 3 reason reason NN cord-023726-2fduzqyb 75 4 , , , cord-023726-2fduzqyb 75 5 as as RB cord-023726-2fduzqyb 75 6 well well RB cord-023726-2fduzqyb 75 7 as as IN cord-023726-2fduzqyb 75 8 for for IN cord-023726-2fduzqyb 75 9 other other JJ cord-023726-2fduzqyb 75 10 reasons reason NNS cord-023726-2fduzqyb 75 11 , , , cord-023726-2fduzqyb 75 12 most most JJS cord-023726-2fduzqyb 75 13 viruses virus NNS cord-023726-2fduzqyb 75 14 have have VBP cord-023726-2fduzqyb 75 15 optimized optimize VBN cord-023726-2fduzqyb 75 16 the the DT cord-023726-2fduzqyb 75 17 information information NN cord-023726-2fduzqyb 75 18 content content NN cord-023726-2fduzqyb 75 19 in in IN cord-023726-2fduzqyb 75 20 their -PRON- PRP$ cord-023726-2fduzqyb 75 21 genomes genome NNS cord-023726-2fduzqyb 75 22 , , , cord-023726-2fduzqyb 75 23 as as IN cord-023726-2fduzqyb 75 24 will will MD cord-023726-2fduzqyb 75 25 be be VB cord-023726-2fduzqyb 75 26 clear clear JJ cord-023726-2fduzqyb 75 27 when when WRB cord-023726-2fduzqyb 75 28 individual individual JJ cord-023726-2fduzqyb 75 29 viruses virus NNS cord-023726-2fduzqyb 75 30 are be VBP cord-023726-2fduzqyb 75 31 discussed discuss VBN cord-023726-2fduzqyb 75 32 in in IN cord-023726-2fduzqyb 75 33 the the DT cord-023726-2fduzqyb 75 34 following follow VBG cord-023726-2fduzqyb 75 35 chapters chapter NNS cord-023726-2fduzqyb 75 36 . . . cord-023726-2fduzqyb 76 1 Cryoelectron Cryoelectron NNP cord-023726-2fduzqyb 76 2 microscopy microscopy NN cord-023726-2fduzqyb 76 3 has have VBZ cord-023726-2fduzqyb 76 4 been be VBN cord-023726-2fduzqyb 76 5 used use VBN cord-023726-2fduzqyb 76 6 to to TO cord-023726-2fduzqyb 76 7 determine determine VB cord-023726-2fduzqyb 76 8 the the DT cord-023726-2fduzqyb 76 9 structure structure NN cord-023726-2fduzqyb 76 10 of of IN cord-023726-2fduzqyb 76 11 numerous numerous JJ cord-023726-2fduzqyb 76 12 icosahedral icosahedral JJ cord-023726-2fduzqyb 76 13 viruses virus NNS cord-023726-2fduzqyb 76 14 to to IN cord-023726-2fduzqyb 76 15 a a DT cord-023726-2fduzqyb 76 16 resolution resolution NN cord-023726-2fduzqyb 76 17 of of IN cord-023726-2fduzqyb 76 18 7 7 CD cord-023726-2fduzqyb 76 19 to to TO cord-023726-2fduzqyb 76 20 25 25 CD cord-023726-2fduzqyb 76 21 Å. Å. NNP cord-023726-2fduzqyb 76 22 For for IN cord-023726-2fduzqyb 76 23 this this DT cord-023726-2fduzqyb 76 24 , , , cord-023726-2fduzqyb 76 25 a a DT cord-023726-2fduzqyb 76 26 virus virus NN cord-023726-2fduzqyb 76 27 - - HYPH cord-023726-2fduzqyb 76 28 containing contain VBG cord-023726-2fduzqyb 76 29 solution solution NN cord-023726-2fduzqyb 76 30 on on IN cord-023726-2fduzqyb 76 31 an an DT cord-023726-2fduzqyb 76 32 electron electron NN cord-023726-2fduzqyb 76 33 microscope microscope NN cord-023726-2fduzqyb 76 34 grid grid NN cord-023726-2fduzqyb 76 35 is be VBZ cord-023726-2fduzqyb 76 36 frozen freeze VBN cord-023726-2fduzqyb 76 37 very very RB cord-023726-2fduzqyb 76 38 rapidly rapidly RB cord-023726-2fduzqyb 76 39 so so IN cord-023726-2fduzqyb 76 40 that that IN cord-023726-2fduzqyb 76 41 the the DT cord-023726-2fduzqyb 76 42 sample sample NN cord-023726-2fduzqyb 76 43 is be VBZ cord-023726-2fduzqyb 76 44 embedded embed VBN cord-023726-2fduzqyb 76 45 in in IN cord-023726-2fduzqyb 76 46 amorphous amorphous JJ cord-023726-2fduzqyb 76 47 frozen frozen JJ cord-023726-2fduzqyb 76 48 water water NN cord-023726-2fduzqyb 76 49 . . . cord-023726-2fduzqyb 77 1 The the DT cord-023726-2fduzqyb 77 2 sample sample NN cord-023726-2fduzqyb 77 3 must must MD cord-023726-2fduzqyb 77 4 be be VB cord-023726-2fduzqyb 77 5 maintained maintain VBN cord-023726-2fduzqyb 77 6 at at IN cord-023726-2fduzqyb 77 7 liquid liquid JJ cord-023726-2fduzqyb 77 8 nitrogen nitrogen NN cord-023726-2fduzqyb 77 9 temperatures temperature NNS cord-023726-2fduzqyb 77 10 so so IN cord-023726-2fduzqyb 77 11 that that IN cord-023726-2fduzqyb 77 12 ice ice NN cord-023726-2fduzqyb 77 13 crystals crystal NNS cord-023726-2fduzqyb 77 14 do do VBP cord-023726-2fduzqyb 77 15 not not RB cord-023726-2fduzqyb 77 16 form form VB cord-023726-2fduzqyb 77 17 and and CC cord-023726-2fduzqyb 77 18 interfere interfere VB cord-023726-2fduzqyb 77 19 with with IN cord-023726-2fduzqyb 77 20 imaging imaging NN cord-023726-2fduzqyb 77 21 . . . cord-023726-2fduzqyb 78 1 Unstained unstained JJ cord-023726-2fduzqyb 78 2 , , , cord-023726-2fduzqyb 78 3 slightly slightly RB cord-023726-2fduzqyb 78 4 out out RB cord-023726-2fduzqyb 78 5 - - HYPH cord-023726-2fduzqyb 78 6 of of IN cord-023726-2fduzqyb 78 7 - - HYPH cord-023726-2fduzqyb 78 8 focus focus NN cord-023726-2fduzqyb 78 9 images image NNS cord-023726-2fduzqyb 78 10 of of IN cord-023726-2fduzqyb 78 11 the the DT cord-023726-2fduzqyb 78 12 virus virus NN cord-023726-2fduzqyb 78 13 are be VBP cord-023726-2fduzqyb 78 14 captured capture VBN cord-023726-2fduzqyb 78 15 on on IN cord-023726-2fduzqyb 78 16 Bluetongue Bluetongue NNP cord-023726-2fduzqyb 78 17 virus virus NN cord-023726-2fduzqyb 78 18 VP7 VP7 NNP cord-023726-2fduzqyb 78 19 T T NNP cord-023726-2fduzqyb 78 20 = = SYM cord-023726-2fduzqyb 78 21 13 13 CD cord-023726-2fduzqyb 78 22 FIGURE figure NN cord-023726-2fduzqyb 78 23 2.4 2.4 CD cord-023726-2fduzqyb 78 24 Structure Structure NNP cord-023726-2fduzqyb 78 25 of of IN cord-023726-2fduzqyb 78 26 three three CD cord-023726-2fduzqyb 78 27 vertebrate vertebrate JJ cord-023726-2fduzqyb 78 28 virus virus NN cord-023726-2fduzqyb 78 29 protein protein NN cord-023726-2fduzqyb 78 30 subunits subunit NNS cord-023726-2fduzqyb 78 31 that that WDT cord-023726-2fduzqyb 78 32 assemble assemble VBP cord-023726-2fduzqyb 78 33 into into IN cord-023726-2fduzqyb 78 34 icosahedral icosahedral JJ cord-023726-2fduzqyb 78 35 shells shell NNS cord-023726-2fduzqyb 78 36 . . . cord-023726-2fduzqyb 79 1 The the DT cord-023726-2fduzqyb 79 2 N n CD cord-023726-2fduzqyb 79 3 termini terminus NNS cord-023726-2fduzqyb 79 4 and and CC cord-023726-2fduzqyb 79 5 C C NNP cord-023726-2fduzqyb 79 6 termini terminus NNS cord-023726-2fduzqyb 79 7 are be VBP cord-023726-2fduzqyb 79 8 labeled label VBN cord-023726-2fduzqyb 79 9 with with IN cord-023726-2fduzqyb 79 10 the the DT cord-023726-2fduzqyb 79 11 residue residue JJ cord-023726-2fduzqyb 79 12 number number NN cord-023726-2fduzqyb 79 13 in in IN cord-023726-2fduzqyb 79 14 parenthesis parenthesis NN cord-023726-2fduzqyb 79 15 . . . cord-023726-2fduzqyb 80 1 The the DT cord-023726-2fduzqyb 80 2 β β NN cord-023726-2fduzqyb 80 3 barrels barrel NNS cord-023726-2fduzqyb 80 4 are be VBP cord-023726-2fduzqyb 80 5 shown show VBN cord-023726-2fduzqyb 80 6 as as IN cord-023726-2fduzqyb 80 7 red red JJ cord-023726-2fduzqyb 80 8 arrows arrow NNS cord-023726-2fduzqyb 80 9 , , , cord-023726-2fduzqyb 80 10 α α NN cord-023726-2fduzqyb 80 11 helices helix NNS cord-023726-2fduzqyb 80 12 are be VBP cord-023726-2fduzqyb 80 13 gray gray JJ cord-023726-2fduzqyb 80 14 coils coil NNS cord-023726-2fduzqyb 80 15 , , , cord-023726-2fduzqyb 80 16 and and CC cord-023726-2fduzqyb 80 17 the the DT cord-023726-2fduzqyb 80 18 subunit subunit NN cord-023726-2fduzqyb 80 19 regions region NNS cord-023726-2fduzqyb 80 20 involved involve VBN cord-023726-2fduzqyb 80 21 in in IN cord-023726-2fduzqyb 80 22 quasi quasi JJ cord-023726-2fduzqyb 80 23 - - JJ cord-023726-2fduzqyb 80 24 symmetric symmetric JJ cord-023726-2fduzqyb 80 25 interactions interaction NNS cord-023726-2fduzqyb 80 26 that that WDT cord-023726-2fduzqyb 80 27 are be VBP cord-023726-2fduzqyb 80 28 critical critical JJ cord-023726-2fduzqyb 80 29 for for IN cord-023726-2fduzqyb 80 30 assembly assembly NN cord-023726-2fduzqyb 80 31 are be VBP cord-023726-2fduzqyb 80 32 colored color VBN cord-023726-2fduzqyb 80 33 green green JJ cord-023726-2fduzqyb 80 34 . . . cord-023726-2fduzqyb 81 1 SV40 SV40 NNP cord-023726-2fduzqyb 81 2 and and CC cord-023726-2fduzqyb 81 3 PV PV NNP cord-023726-2fduzqyb 81 4 have have VBP cord-023726-2fduzqyb 81 5 triangulation triangulation NN cord-023726-2fduzqyb 81 6 numbers number NNS cord-023726-2fduzqyb 81 7 of of IN cord-023726-2fduzqyb 81 8 " " `` cord-023726-2fduzqyb 81 9 pseudo pseudo JJ cord-023726-2fduzqyb 81 10 - - HYPH cord-023726-2fduzqyb 81 11 T=7 T=7 NNP cord-023726-2fduzqyb 81 12 " " '' cord-023726-2fduzqyb 81 13 or or CC cord-023726-2fduzqyb 81 14 P p NN cord-023726-2fduzqyb 81 15 = = SYM cord-023726-2fduzqyb 81 16 7 7 CD cord-023726-2fduzqyb 81 17 and and CC cord-023726-2fduzqyb 81 18 " " `` cord-023726-2fduzqyb 81 19 pseudo pseudo JJ cord-023726-2fduzqyb 81 20 - - HYPH cord-023726-2fduzqyb 81 21 T=3 T=3 NNP cord-023726-2fduzqyb 81 22 " " '' cord-023726-2fduzqyb 81 23 or or CC cord-023726-2fduzqyb 81 24 P p NN cord-023726-2fduzqyb 81 25 = = SYM cord-023726-2fduzqyb 81 26 3 3 CD cord-023726-2fduzqyb 81 27 , , , cord-023726-2fduzqyb 81 28 respectively respectively RB cord-023726-2fduzqyb 81 29 . . . cord-023726-2fduzqyb 82 1 Adapted adapt VBN cord-023726-2fduzqyb 82 2 from from IN cord-023726-2fduzqyb 82 3 Granoff Granoff NNP cord-023726-2fduzqyb 82 4 and and CC cord-023726-2fduzqyb 82 5 Webster Webster NNP cord-023726-2fduzqyb 82 6 ( ( -LRB- cord-023726-2fduzqyb 82 7 1999 1999 CD cord-023726-2fduzqyb 82 8 ) ) -RRB- cord-023726-2fduzqyb 82 9 , , , cord-023726-2fduzqyb 82 10 Vol Vol NNP cord-023726-2fduzqyb 82 11 . . . cord-023726-2fduzqyb 83 1 3 3 LS cord-023726-2fduzqyb 83 2 , , , cord-023726-2fduzqyb 83 3 plate plate NN cord-023726-2fduzqyb 83 4 32 32 CD cord-023726-2fduzqyb 83 5 . . . cord-023726-2fduzqyb 84 1 film film NN cord-023726-2fduzqyb 84 2 , , , cord-023726-2fduzqyb 84 3 or or CC cord-023726-2fduzqyb 84 4 more more RBR cord-023726-2fduzqyb 84 5 recently recently RB cord-023726-2fduzqyb 84 6 captured capture VBN cord-023726-2fduzqyb 84 7 electronically electronically RB cord-023726-2fduzqyb 84 8 , , , cord-023726-2fduzqyb 84 9 using use VBG cord-023726-2fduzqyb 84 10 a a DT cord-023726-2fduzqyb 84 11 low low JJ cord-023726-2fduzqyb 84 12 dose dose NN cord-023726-2fduzqyb 84 13 of of IN cord-023726-2fduzqyb 84 14 electrons electron NNS cord-023726-2fduzqyb 84 15 . . . cord-023726-2fduzqyb 85 1 These these DT cord-023726-2fduzqyb 85 2 images image NNS cord-023726-2fduzqyb 85 3 are be VBP cord-023726-2fduzqyb 85 4 digitized digitize VBN cord-023726-2fduzqyb 85 5 and and CC cord-023726-2fduzqyb 85 6 the the DT cord-023726-2fduzqyb 85 7 density density NN cord-023726-2fduzqyb 85 8 measured measure VBN cord-023726-2fduzqyb 85 9 . . . cord-023726-2fduzqyb 86 1 Mathematical mathematical JJ cord-023726-2fduzqyb 86 2 algorithms algorithm NNS cord-023726-2fduzqyb 86 3 that that WDT cord-023726-2fduzqyb 86 4 take take VBP cord-023726-2fduzqyb 86 5 advantage advantage NN cord-023726-2fduzqyb 86 6 of of IN cord-023726-2fduzqyb 86 7 the the DT cord-023726-2fduzqyb 86 8 symmetry symmetry NN cord-023726-2fduzqyb 86 9 of of IN cord-023726-2fduzqyb 86 10 the the DT cord-023726-2fduzqyb 86 11 particle particle NN cord-023726-2fduzqyb 86 12 are be VBP cord-023726-2fduzqyb 86 13 used use VBN cord-023726-2fduzqyb 86 14 to to TO cord-023726-2fduzqyb 86 15 reconstruct reconstruct VB cord-023726-2fduzqyb 86 16 the the DT cord-023726-2fduzqyb 86 17 structure structure NN cord-023726-2fduzqyb 86 18 of of IN cord-023726-2fduzqyb 86 19 the the DT cord-023726-2fduzqyb 86 20 particle particle NN cord-023726-2fduzqyb 86 21 . . . cord-023726-2fduzqyb 87 1 A a DT cord-023726-2fduzqyb 87 2 gallery gallery NN cord-023726-2fduzqyb 87 3 of of IN cord-023726-2fduzqyb 87 4 structures structure NNS cord-023726-2fduzqyb 87 5 of of IN cord-023726-2fduzqyb 87 6 viruses virus NNS cord-023726-2fduzqyb 87 7 determined determine VBN cord-023726-2fduzqyb 87 8 by by IN cord-023726-2fduzqyb 87 9 cryoelectron cryoelectron NNP cord-023726-2fduzqyb 87 10 microscopy microscopy NNP cord-023726-2fduzqyb 87 11 is be VBZ cord-023726-2fduzqyb 87 12 shown show VBN cord-023726-2fduzqyb 87 13 in in IN cord-023726-2fduzqyb 87 14 Fig Fig NNP cord-023726-2fduzqyb 87 15 . . . cord-023726-2fduzqyb 88 1 2 2 LS cord-023726-2fduzqyb 88 2 .5 .5 CD cord-023726-2fduzqyb 88 3 . . . cord-023726-2fduzqyb 89 1 All all DT cord-023726-2fduzqyb 89 2 of of IN cord-023726-2fduzqyb 89 3 the the DT cord-023726-2fduzqyb 89 4 images image NNS cord-023726-2fduzqyb 89 5 are be VBP cord-023726-2fduzqyb 89 6 to to TO cord-023726-2fduzqyb 89 7 scale scale VB cord-023726-2fduzqyb 89 8 so so IN cord-023726-2fduzqyb 89 9 that that IN cord-023726-2fduzqyb 89 10 the the DT cord-023726-2fduzqyb 89 11 relative relative JJ cord-023726-2fduzqyb 89 12 sizes size NNS cord-023726-2fduzqyb 89 13 of of IN cord-023726-2fduzqyb 89 14 the the DT cord-023726-2fduzqyb 89 15 virions virion NNS cord-023726-2fduzqyb 89 16 are be VBP cord-023726-2fduzqyb 89 17 apparent apparent JJ cord-023726-2fduzqyb 89 18 . . . cord-023726-2fduzqyb 90 1 The the DT cord-023726-2fduzqyb 90 2 largest large JJS cord-023726-2fduzqyb 90 3 particle particle NN cord-023726-2fduzqyb 90 4 is be VBZ cord-023726-2fduzqyb 90 5 the the DT cord-023726-2fduzqyb 90 6 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 90 7 of of IN cord-023726-2fduzqyb 90 8 herpes herpes NNP cord-023726-2fduzqyb 90 9 simplex simplex NNP cord-023726-2fduzqyb 90 10 virus virus NN cord-023726-2fduzqyb 90 11 , , , cord-023726-2fduzqyb 90 12 which which WDT cord-023726-2fduzqyb 90 13 is be VBZ cord-023726-2fduzqyb 90 14 1250 1250 CD cord-023726-2fduzqyb 90 15 Å å NN cord-023726-2fduzqyb 90 16 in in IN cord-023726-2fduzqyb 90 17 diameter diameter NN cord-023726-2fduzqyb 90 18 and and CC cord-023726-2fduzqyb 90 19 has have VBZ cord-023726-2fduzqyb 90 20 T=16 T=16 NNP cord-023726-2fduzqyb 90 21 symmetry symmetry NN cord-023726-2fduzqyb 90 22 ( ( -LRB- cord-023726-2fduzqyb 90 23 the the DT cord-023726-2fduzqyb 90 24 virion virion NN cord-023726-2fduzqyb 90 25 is be VBZ cord-023726-2fduzqyb 90 26 enveloped envelop VBN cord-023726-2fduzqyb 90 27 but but CC cord-023726-2fduzqyb 90 28 only only RB cord-023726-2fduzqyb 90 29 the the DT cord-023726-2fduzqyb 90 30 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 90 31 is be VBZ cord-023726-2fduzqyb 90 32 regular regular JJ cord-023726-2fduzqyb 90 33 FIGURE FIGURE NNP cord-023726-2fduzqyb 90 34 2.5 2.5 CD cord-023726-2fduzqyb 90 35 Gallery Gallery NNP cord-023726-2fduzqyb 90 36 of of IN cord-023726-2fduzqyb 90 37 three three CD cord-023726-2fduzqyb 90 38 - - HYPH cord-023726-2fduzqyb 90 39 dimensional dimensional JJ cord-023726-2fduzqyb 90 40 reconstructions reconstruction NNS cord-023726-2fduzqyb 90 41 of of IN cord-023726-2fduzqyb 90 42 icosahedral icosahedral JJ cord-023726-2fduzqyb 90 43 viruses virus NNS cord-023726-2fduzqyb 90 44 from from IN cord-023726-2fduzqyb 90 45 cryoelectron cryoelectron NNP cord-023726-2fduzqyb 90 46 micrographs micrograph NNS cord-023726-2fduzqyb 90 47 . . . cord-023726-2fduzqyb 91 1 All all DT cord-023726-2fduzqyb 91 2 virus virus NN cord-023726-2fduzqyb 91 3 structures structure NNS cord-023726-2fduzqyb 91 4 are be VBP cord-023726-2fduzqyb 91 5 surface surface NN cord-023726-2fduzqyb 91 6 shaded shaded JJ cord-023726-2fduzqyb 91 7 and and CC cord-023726-2fduzqyb 91 8 are be VBP cord-023726-2fduzqyb 91 9 viewed view VBN cord-023726-2fduzqyb 91 10 along along IN cord-023726-2fduzqyb 91 11 a a DT cord-023726-2fduzqyb 91 12 twofold twofold JJ cord-023726-2fduzqyb 91 13 axis axis NN cord-023726-2fduzqyb 91 14 of of IN cord-023726-2fduzqyb 91 15 symmetry symmetry NN cord-023726-2fduzqyb 91 16 except except IN cord-023726-2fduzqyb 91 17 Ross Ross NNP cord-023726-2fduzqyb 91 18 River River NNP cord-023726-2fduzqyb 91 19 , , , cord-023726-2fduzqyb 91 20 which which WDT cord-023726-2fduzqyb 91 21 is be VBZ cord-023726-2fduzqyb 91 22 viewed view VBN cord-023726-2fduzqyb 91 23 along along IN cord-023726-2fduzqyb 91 24 a a DT cord-023726-2fduzqyb 91 25 three three CD cord-023726-2fduzqyb 91 26 - - HYPH cord-023726-2fduzqyb 91 27 fold fold JJ cord-023726-2fduzqyb 91 28 axis axis NN cord-023726-2fduzqyb 91 29 . . . cord-023726-2fduzqyb 92 1 All all DT cord-023726-2fduzqyb 92 2 of of IN cord-023726-2fduzqyb 92 3 the the DT cord-023726-2fduzqyb 92 4 images image NNS cord-023726-2fduzqyb 92 5 are be VBP cord-023726-2fduzqyb 92 6 of of IN cord-023726-2fduzqyb 92 7 intact intact JJ cord-023726-2fduzqyb 92 8 virus virus NN cord-023726-2fduzqyb 92 9 particles particle NNS cord-023726-2fduzqyb 92 10 except except IN cord-023726-2fduzqyb 92 11 for for IN cord-023726-2fduzqyb 92 12 the the DT cord-023726-2fduzqyb 92 13 herpes herpes NNP cord-023726-2fduzqyb 92 14 simplex simplex NNP cord-023726-2fduzqyb 92 15 structure structure NN cord-023726-2fduzqyb 92 16 , , , cord-023726-2fduzqyb 92 17 which which WDT cord-023726-2fduzqyb 92 18 is be VBZ cord-023726-2fduzqyb 92 19 of of IN cord-023726-2fduzqyb 92 20 the the DT cord-023726-2fduzqyb 92 21 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 92 22 of of IN cord-023726-2fduzqyb 92 23 the the DT cord-023726-2fduzqyb 92 24 virus virus NN cord-023726-2fduzqyb 92 25 . . . cord-023726-2fduzqyb 93 1 Most Most JJS cord-023726-2fduzqyb 93 2 of of IN cord-023726-2fduzqyb 93 3 the the DT cord-023726-2fduzqyb 93 4 images image NNS cord-023726-2fduzqyb 93 5 are be VBP cord-023726-2fduzqyb 93 6 taken take VBN cord-023726-2fduzqyb 93 7 from from IN cord-023726-2fduzqyb 93 8 Baker Baker NNP cord-023726-2fduzqyb 93 9 et et NNP cord-023726-2fduzqyb 93 10 al al NNP cord-023726-2fduzqyb 93 11 . . . cord-023726-2fduzqyb 94 1 ( ( -LRB- cord-023726-2fduzqyb 94 2 1999 1999 CD cord-023726-2fduzqyb 94 3 ) ) -RRB- cord-023726-2fduzqyb 94 4 , , , cord-023726-2fduzqyb 94 5 except except IN cord-023726-2fduzqyb 94 6 the the DT cord-023726-2fduzqyb 94 7 images image NNS cord-023726-2fduzqyb 94 8 of of IN cord-023726-2fduzqyb 94 9 Ross Ross NNP cord-023726-2fduzqyb 94 10 River River NNP cord-023726-2fduzqyb 94 11 virus virus NN cord-023726-2fduzqyb 94 12 and and CC cord-023726-2fduzqyb 94 13 of of IN cord-023726-2fduzqyb 94 14 dengue dengue NN cord-023726-2fduzqyb 94 15 virus virus NN cord-023726-2fduzqyb 94 16 , , , cord-023726-2fduzqyb 94 17 which which WDT cord-023726-2fduzqyb 94 18 were be VBD cord-023726-2fduzqyb 94 19 kindly kindly RB cord-023726-2fduzqyb 94 20 provided provide VBN cord-023726-2fduzqyb 94 21 by by IN cord-023726-2fduzqyb 94 22 Drs Drs NNP cord-023726-2fduzqyb 94 23 . . . cord-023726-2fduzqyb 95 1 R. R. NNP cord-023726-2fduzqyb 95 2 J. J. NNP cord-023726-2fduzqyb 95 3 Kuhn Kuhn NNP cord-023726-2fduzqyb 95 4 and and CC cord-023726-2fduzqyb 95 5 T. T. NNP cord-023726-2fduzqyb 95 6 S. S. NNP cord-023726-2fduzqyb 95 7 Baker Baker NNP cord-023726-2fduzqyb 95 8 . . . cord-023726-2fduzqyb 96 1 rest rest NN cord-023726-2fduzqyb 96 2 are be VBP cord-023726-2fduzqyb 96 3 not not RB cord-023726-2fduzqyb 96 4 enveloped envelop VBN cord-023726-2fduzqyb 96 5 ) ) -RRB- cord-023726-2fduzqyb 96 6 . . . cord-023726-2fduzqyb 97 1 B19 B19 NNP cord-023726-2fduzqyb 97 2 parvovirus parvovirus NN cord-023726-2fduzqyb 97 3 has have VBZ cord-023726-2fduzqyb 97 4 T=1 T=1 NNP cord-023726-2fduzqyb 97 5 . . . cord-023726-2fduzqyb 98 1 The the DT cord-023726-2fduzqyb 98 2 general general JJ cord-023726-2fduzqyb 98 3 correlation correlation NN cord-023726-2fduzqyb 98 4 is be VBZ cord-023726-2fduzqyb 98 5 that that IN cord-023726-2fduzqyb 98 6 larger large JJR cord-023726-2fduzqyb 98 7 particles particle NNS cord-023726-2fduzqyb 98 8 are be VBP cord-023726-2fduzqyb 98 9 constructed construct VBN cord-023726-2fduzqyb 98 10 using use VBG cord-023726-2fduzqyb 98 11 higher high JJR cord-023726-2fduzqyb 98 12 triangulation triangulation NN cord-023726-2fduzqyb 98 13 numbers number NNS cord-023726-2fduzqyb 98 14 , , , cord-023726-2fduzqyb 98 15 which which WDT cord-023726-2fduzqyb 98 16 allows allow VBZ cord-023726-2fduzqyb 98 17 the the DT cord-023726-2fduzqyb 98 18 use use NN cord-023726-2fduzqyb 98 19 of of IN cord-023726-2fduzqyb 98 20 larger large JJR cord-023726-2fduzqyb 98 21 numbers number NNS cord-023726-2fduzqyb 98 22 of of IN cord-023726-2fduzqyb 98 23 protein protein NN cord-023726-2fduzqyb 98 24 subunits subunit NNS cord-023726-2fduzqyb 98 25 . . . cord-023726-2fduzqyb 99 1 Larger large JJR cord-023726-2fduzqyb 99 2 particles particle NNS cord-023726-2fduzqyb 99 3 accommodate accommodate VBP cord-023726-2fduzqyb 99 4 larger large JJR cord-023726-2fduzqyb 99 5 genomes genome NNS cord-023726-2fduzqyb 99 6 . . . cord-023726-2fduzqyb 100 1 Because because IN cord-023726-2fduzqyb 100 2 the the DT cord-023726-2fduzqyb 100 3 simplest simple JJS cord-023726-2fduzqyb 100 4 viruses virus NNS cord-023726-2fduzqyb 100 5 are be VBP cord-023726-2fduzqyb 100 6 regular regular JJ cord-023726-2fduzqyb 100 7 structures structure NNS cord-023726-2fduzqyb 100 8 , , , cord-023726-2fduzqyb 100 9 they -PRON- PRP cord-023726-2fduzqyb 100 10 will will MD cord-023726-2fduzqyb 100 11 often often RB cord-023726-2fduzqyb 100 12 crystallize crystallize VB cord-023726-2fduzqyb 100 13 , , , cord-023726-2fduzqyb 100 14 and and CC cord-023726-2fduzqyb 100 15 such such JJ cord-023726-2fduzqyb 100 16 crystals crystal NNS cord-023726-2fduzqyb 100 17 may may MD cord-023726-2fduzqyb 100 18 be be VB cord-023726-2fduzqyb 100 19 suitable suitable JJ cord-023726-2fduzqyb 100 20 for for IN cord-023726-2fduzqyb 100 21 X x NN cord-023726-2fduzqyb 100 22 - - NN cord-023726-2fduzqyb 100 23 ray ray NN cord-023726-2fduzqyb 100 24 diffraction diffraction NN cord-023726-2fduzqyb 100 25 . . . cord-023726-2fduzqyb 101 1 Many many JJ cord-023726-2fduzqyb 101 2 viruses virus NNS cord-023726-2fduzqyb 101 3 formed form VBN cord-023726-2fduzqyb 101 4 using use VBG cord-023726-2fduzqyb 101 5 icosahedral icosahedral JJ cord-023726-2fduzqyb 101 6 symmetry symmetry NN cord-023726-2fduzqyb 101 7 principles principle NNS cord-023726-2fduzqyb 101 8 have have VBP cord-023726-2fduzqyb 101 9 been be VBN cord-023726-2fduzqyb 101 10 solved solve VBN cord-023726-2fduzqyb 101 11 to to IN cord-023726-2fduzqyb 101 12 atomic atomic JJ cord-023726-2fduzqyb 101 13 resolution resolution NN cord-023726-2fduzqyb 101 14 , , , cord-023726-2fduzqyb 101 15 and and CC cord-023726-2fduzqyb 101 16 a a DT cord-023726-2fduzqyb 101 17 discussion discussion NN cord-023726-2fduzqyb 101 18 of of IN cord-023726-2fduzqyb 101 19 representative representative JJ cord-023726-2fduzqyb 101 20 viruses virus NNS cord-023726-2fduzqyb 101 21 that that WDT cord-023726-2fduzqyb 101 22 illustrate illustrate VBP cord-023726-2fduzqyb 101 23 the the DT cord-023726-2fduzqyb 101 24 principles principle NNS cord-023726-2fduzqyb 101 25 used use VBN cord-023726-2fduzqyb 101 26 in in IN cord-023726-2fduzqyb 101 27 construction construction NN cord-023726-2fduzqyb 101 28 of of IN cord-023726-2fduzqyb 101 29 various various JJ cord-023726-2fduzqyb 101 30 viruses virus NNS cord-023726-2fduzqyb 101 31 is be VBZ cord-023726-2fduzqyb 101 32 presented present VBN cord-023726-2fduzqyb 101 33 here here RB cord-023726-2fduzqyb 101 34 . . . cord-023726-2fduzqyb 102 1 Among among IN cord-023726-2fduzqyb 102 2 T=3 T=3 NNP cord-023726-2fduzqyb 102 3 viruses virus NNS cord-023726-2fduzqyb 102 4 , , , cord-023726-2fduzqyb 102 5 the the DT cord-023726-2fduzqyb 102 6 structures structure NNS cord-023726-2fduzqyb 102 7 of of IN cord-023726-2fduzqyb 102 8 several several JJ cord-023726-2fduzqyb 102 9 plant plant NN cord-023726-2fduzqyb 102 10 viruses virus NNS cord-023726-2fduzqyb 102 11 , , , cord-023726-2fduzqyb 102 12 including include VBG cord-023726-2fduzqyb 102 13 tomato tomato NN cord-023726-2fduzqyb 102 14 bushy bushy JJ cord-023726-2fduzqyb 102 15 stunt stunt NN cord-023726-2fduzqyb 102 16 virus virus NN cord-023726-2fduzqyb 102 17 ( ( -LRB- cord-023726-2fduzqyb 102 18 TBSV TBSV NNP cord-023726-2fduzqyb 102 19 ) ) -RRB- cord-023726-2fduzqyb 102 20 ( ( -LRB- cord-023726-2fduzqyb 102 21 genus genus NNP cord-023726-2fduzqyb 102 22 Tombusvirus Tombusvirus NNP cord-023726-2fduzqyb 102 23 , , , cord-023726-2fduzqyb 102 24 family family NN cord-023726-2fduzqyb 102 25 Tombusviridae Tombusviridae NNP cord-023726-2fduzqyb 102 26 ) ) -RRB- cord-023726-2fduzqyb 102 27 , , , cord-023726-2fduzqyb 102 28 turnip turnip NN cord-023726-2fduzqyb 102 29 crinkle crinkle NN cord-023726-2fduzqyb 102 30 virus virus NN cord-023726-2fduzqyb 102 31 ( ( -LRB- cord-023726-2fduzqyb 102 32 TCV TCV NNP cord-023726-2fduzqyb 102 33 ) ) -RRB- cord-023726-2fduzqyb 102 34 ( ( -LRB- cord-023726-2fduzqyb 102 35 genus genus NN cord-023726-2fduzqyb 102 36 Carmovirus Carmovirus NNP cord-023726-2fduzqyb 102 37 , , , cord-023726-2fduzqyb 102 38 family family NN cord-023726-2fduzqyb 102 39 Tombusviridae Tombusviridae NNP cord-023726-2fduzqyb 102 40 ) ) -RRB- cord-023726-2fduzqyb 102 41 , , , cord-023726-2fduzqyb 102 42 and and CC cord-023726-2fduzqyb 102 43 Southern southern JJ cord-023726-2fduzqyb 102 44 bean bean NN cord-023726-2fduzqyb 102 45 mosaic mosaic NN cord-023726-2fduzqyb 102 46 virus virus NN cord-023726-2fduzqyb 102 47 ( ( -LRB- cord-023726-2fduzqyb 102 48 SBMV SBMV NNP cord-023726-2fduzqyb 102 49 ) ) -RRB- cord-023726-2fduzqyb 102 50 ( ( -LRB- cord-023726-2fduzqyb 102 51 genus genus NN cord-023726-2fduzqyb 102 52 Sobemovirus Sobemovirus NNP cord-023726-2fduzqyb 102 53 , , , cord-023726-2fduzqyb 102 54 not not RB cord-023726-2fduzqyb 102 55 yet yet RB cord-023726-2fduzqyb 102 56 assigned assign VBN cord-023726-2fduzqyb 102 57 to to IN cord-023726-2fduzqyb 102 58 family family NN cord-023726-2fduzqyb 102 59 ) ) -RRB- cord-023726-2fduzqyb 102 60 , , , cord-023726-2fduzqyb 102 61 have have VBP cord-023726-2fduzqyb 102 62 been be VBN cord-023726-2fduzqyb 102 63 solved solve VBN cord-023726-2fduzqyb 102 64 . . . cord-023726-2fduzqyb 103 1 All all DT cord-023726-2fduzqyb 103 2 three three CD cord-023726-2fduzqyb 103 3 of of IN cord-023726-2fduzqyb 103 4 these these DT cord-023726-2fduzqyb 103 5 viruses virus NNS cord-023726-2fduzqyb 103 6 have have VBP cord-023726-2fduzqyb 103 7 capsid capsid NN cord-023726-2fduzqyb 103 8 proteins protein NNS cord-023726-2fduzqyb 103 9 possessing possess VBG cord-023726-2fduzqyb 103 10 the the DT cord-023726-2fduzqyb 103 11 eight eight CD cord-023726-2fduzqyb 103 12 - - HYPH cord-023726-2fduzqyb 103 13 stranded stranded JJ cord-023726-2fduzqyb 103 14 antiparallel antiparallel IN cord-023726-2fduzqyb 103 15 β β DT cord-023726-2fduzqyb 103 16 sandwich sandwich NN cord-023726-2fduzqyb 103 17 . . . cord-023726-2fduzqyb 104 1 T=3 T=3 NNP cord-023726-2fduzqyb 104 2 means mean VBZ cord-023726-2fduzqyb 104 3 that that IN cord-023726-2fduzqyb 104 4 180 180 CD cord-023726-2fduzqyb 104 5 identical identical JJ cord-023726-2fduzqyb 104 6 molecules molecule NNS cord-023726-2fduzqyb 104 7 of of IN cord-023726-2fduzqyb 104 8 capsid capsid NN cord-023726-2fduzqyb 104 9 protein protein NN cord-023726-2fduzqyb 104 10 are be VBP cord-023726-2fduzqyb 104 11 utilized utilize VBN cord-023726-2fduzqyb 104 12 to to TO cord-023726-2fduzqyb 104 13 construct construct VB cord-023726-2fduzqyb 104 14 the the DT cord-023726-2fduzqyb 104 15 shell shell NN cord-023726-2fduzqyb 104 16 . . . cord-023726-2fduzqyb 105 1 The the DT cord-023726-2fduzqyb 105 2 structures structure NNS cord-023726-2fduzqyb 105 3 of of IN cord-023726-2fduzqyb 105 4 two two CD cord-023726-2fduzqyb 105 5 insect insect NN cord-023726-2fduzqyb 105 6 viruses virus NNS cord-023726-2fduzqyb 105 7 that that WDT cord-023726-2fduzqyb 105 8 are be VBP cord-023726-2fduzqyb 105 9 also also RB cord-023726-2fduzqyb 105 10 simple simple JJ cord-023726-2fduzqyb 105 11 T=3 T=3 NNP cord-023726-2fduzqyb 105 12 structures structure NNS cord-023726-2fduzqyb 105 13 have have VBP cord-023726-2fduzqyb 105 14 also also RB cord-023726-2fduzqyb 105 15 been be VBN cord-023726-2fduzqyb 105 16 solved solve VBN cord-023726-2fduzqyb 105 17 . . . cord-023726-2fduzqyb 106 1 As as IN cord-023726-2fduzqyb 106 2 an an DT cord-023726-2fduzqyb 106 3 example example NN cord-023726-2fduzqyb 106 4 of of IN cord-023726-2fduzqyb 106 5 these these DT cord-023726-2fduzqyb 106 6 simple simple JJ cord-023726-2fduzqyb 106 7 structures structure NNS cord-023726-2fduzqyb 106 8 , , , cord-023726-2fduzqyb 106 9 the the DT cord-023726-2fduzqyb 106 10 T=3 T=3 NNP cord-023726-2fduzqyb 106 11 capsid capsid NN cord-023726-2fduzqyb 106 12 of of IN cord-023726-2fduzqyb 106 13 the the DT cord-023726-2fduzqyb 106 14 insect insect NN cord-023726-2fduzqyb 106 15 virus virus NN cord-023726-2fduzqyb 106 16 , , , cord-023726-2fduzqyb 106 17 flock flock VB cord-023726-2fduzqyb 106 18 house house NN cord-023726-2fduzqyb 106 19 virus virus NN cord-023726-2fduzqyb 106 20 ( ( -LRB- cord-023726-2fduzqyb 106 21 family family NN cord-023726-2fduzqyb 106 22 Nodaviridae Nodaviridae NNP cord-023726-2fduzqyb 106 23 ) ) -RRB- cord-023726-2fduzqyb 106 24 , , , cord-023726-2fduzqyb 106 25 is be VBZ cord-023726-2fduzqyb 106 26 illustrated illustrate VBN cord-023726-2fduzqyb 106 27 in in IN cord-023726-2fduzqyb 106 28 Fig Fig NNP cord-023726-2fduzqyb 106 29 . . . cord-023726-2fduzqyb 107 1 2 2 LS cord-023726-2fduzqyb 107 2 .6 .6 NFP cord-023726-2fduzqyb 107 3 . . . cord-023726-2fduzqyb 108 1 The the DT cord-023726-2fduzqyb 108 2 180 180 CD cord-023726-2fduzqyb 108 3 subunits subunit NNS cord-023726-2fduzqyb 108 4 in in IN cord-023726-2fduzqyb 108 5 these these DT cord-023726-2fduzqyb 108 6 T=3 T=3 NNP cord-023726-2fduzqyb 108 7 structures structure NNS cord-023726-2fduzqyb 108 8 interact interact VBP cord-023726-2fduzqyb 108 9 with with IN cord-023726-2fduzqyb 108 10 one one CD cord-023726-2fduzqyb 108 11 another another DT cord-023726-2fduzqyb 108 12 in in IN cord-023726-2fduzqyb 108 13 one one CD cord-023726-2fduzqyb 108 14 of of IN cord-023726-2fduzqyb 108 15 two two CD cord-023726-2fduzqyb 108 16 different different JJ cord-023726-2fduzqyb 108 17 ways way NNS cord-023726-2fduzqyb 108 18 , , , cord-023726-2fduzqyb 108 19 such such JJ cord-023726-2fduzqyb 108 20 that that IN cord-023726-2fduzqyb 108 21 the the DT cord-023726-2fduzqyb 108 22 protein protein NN cord-023726-2fduzqyb 108 23 shell shell NN cord-023726-2fduzqyb 108 24 can can MD cord-023726-2fduzqyb 108 25 be be VB cord-023726-2fduzqyb 108 26 thought think VBN cord-023726-2fduzqyb 108 27 of of IN cord-023726-2fduzqyb 108 28 as as IN cord-023726-2fduzqyb 108 29 being be VBG cord-023726-2fduzqyb 108 30 composed compose VBN cord-023726-2fduzqyb 108 31 of of IN cord-023726-2fduzqyb 108 32 an an DT cord-023726-2fduzqyb 108 33 assembly assembly NN cord-023726-2fduzqyb 108 34 of of IN cord-023726-2fduzqyb 108 35 60 60 CD cord-023726-2fduzqyb 108 36 AB AB NNP cord-023726-2fduzqyb 108 37 dimers dimer NNS cord-023726-2fduzqyb 108 38 and and CC cord-023726-2fduzqyb 108 39 30 30 CD cord-023726-2fduzqyb 108 40 CC cc NN cord-023726-2fduzqyb 108 41 dimers dimer NNS cord-023726-2fduzqyb 108 42 ( ( -LRB- cord-023726-2fduzqyb 108 43 Fig Fig NNP cord-023726-2fduzqyb 108 44 . . . cord-023726-2fduzqyb 108 45 2.6A 2.6A NNP cord-023726-2fduzqyb 108 46 ) ) -RRB- cord-023726-2fduzqyb 108 47 . . . cord-023726-2fduzqyb 109 1 The the DT cord-023726-2fduzqyb 109 2 bond bond NN cord-023726-2fduzqyb 109 3 angle angle NN cord-023726-2fduzqyb 109 4 between between IN cord-023726-2fduzqyb 109 5 the the DT cord-023726-2fduzqyb 109 6 two two CD cord-023726-2fduzqyb 109 7 subunits subunit NNS cord-023726-2fduzqyb 109 8 of of IN cord-023726-2fduzqyb 109 9 the the DT cord-023726-2fduzqyb 109 10 dimer dimer NN cord-023726-2fduzqyb 109 11 is be VBZ cord-023726-2fduzqyb 109 12 more more RBR cord-023726-2fduzqyb 109 13 acute acute JJ cord-023726-2fduzqyb 109 14 in in IN cord-023726-2fduzqyb 109 15 the the DT cord-023726-2fduzqyb 109 16 AB AB NNP cord-023726-2fduzqyb 109 17 dimers dimer NNS cord-023726-2fduzqyb 109 18 than than IN cord-023726-2fduzqyb 109 19 in in IN cord-023726-2fduzqyb 109 20 the the DT cord-023726-2fduzqyb 109 21 CC cc NN cord-023726-2fduzqyb 109 22 dimers dimer NNS cord-023726-2fduzqyb 109 23 ( ( -LRB- cord-023726-2fduzqyb 109 24 Figs fig NNS cord-023726-2fduzqyb 109 25 . . . cord-023726-2fduzqyb 109 26 2.6B 2.6B NNP cord-023726-2fduzqyb 109 27 and and CC cord-023726-2fduzqyb 109 28 C C NNP cord-023726-2fduzqyb 109 29 ) ) -RRB- cord-023726-2fduzqyb 109 30 . . . cord-023726-2fduzqyb 110 1 For for IN cord-023726-2fduzqyb 110 2 the the DT cord-023726-2fduzqyb 110 3 plant plant NN cord-023726-2fduzqyb 110 4 viruses virus NNS cord-023726-2fduzqyb 110 5 , , , cord-023726-2fduzqyb 110 6 there there EX cord-023726-2fduzqyb 110 7 are be VBP cord-023726-2fduzqyb 110 8 N n NN cord-023726-2fduzqyb 110 9 - - HYPH cord-023726-2fduzqyb 110 10 terminal terminal NN cord-023726-2fduzqyb 110 11 and and CC cord-023726-2fduzqyb 110 12 C c NN cord-023726-2fduzqyb 110 13 - - HYPH cord-023726-2fduzqyb 110 14 terminal terminal NN cord-023726-2fduzqyb 110 15 extensions extension NNS cord-023726-2fduzqyb 110 16 from from IN cord-023726-2fduzqyb 110 17 the the DT cord-023726-2fduzqyb 110 18 capsid capsid NN cord-023726-2fduzqyb 110 19 proteins protein NNS cord-023726-2fduzqyb 110 20 that that WDT cord-023726-2fduzqyb 110 21 are be VBP cord-023726-2fduzqyb 110 22 involved involve VBN cord-023726-2fduzqyb 110 23 in in IN cord-023726-2fduzqyb 110 24 interactions interaction NNS cord-023726-2fduzqyb 110 25 between between IN cord-023726-2fduzqyb 110 26 the the DT cord-023726-2fduzqyb 110 27 subunits subunit NNS cord-023726-2fduzqyb 110 28 and and CC cord-023726-2fduzqyb 110 29 with with IN cord-023726-2fduzqyb 110 30 the the DT cord-023726-2fduzqyb 110 31 RNA RNA NNP cord-023726-2fduzqyb 110 32 . . . cord-023726-2fduzqyb 111 1 The the DT cord-023726-2fduzqyb 111 2 N n CD cord-023726-2fduzqyb 111 3 - - HYPH cord-023726-2fduzqyb 111 4 terminal terminal NN cord-023726-2fduzqyb 111 5 extensions extension NNS cord-023726-2fduzqyb 111 6 have have VBP cord-023726-2fduzqyb 111 7 a a DT cord-023726-2fduzqyb 111 8 positively positively RB cord-023726-2fduzqyb 111 9 charged charge VBN cord-023726-2fduzqyb 111 10 , , , cord-023726-2fduzqyb 111 11 disordered disordered JJ cord-023726-2fduzqyb 111 12 domain domain NN cord-023726-2fduzqyb 111 13 for for IN cord-023726-2fduzqyb 111 14 interacting interact VBG cord-023726-2fduzqyb 111 15 with with IN cord-023726-2fduzqyb 111 16 and and CC cord-023726-2fduzqyb 111 17 neutralizing neutralize VBG cord-023726-2fduzqyb 111 18 the the DT cord-023726-2fduzqyb 111 19 charge charge NN cord-023726-2fduzqyb 111 20 on on IN cord-023726-2fduzqyb 111 21 the the DT cord-023726-2fduzqyb 111 22 RNA RNA NNP cord-023726-2fduzqyb 111 23 and and CC cord-023726-2fduzqyb 111 24 a a DT cord-023726-2fduzqyb 111 25 connecting connect VBG cord-023726-2fduzqyb 111 26 arm arm NN cord-023726-2fduzqyb 111 27 that that WDT cord-023726-2fduzqyb 111 28 interacts interact VBZ cord-023726-2fduzqyb 111 29 with with IN cord-023726-2fduzqyb 111 30 other other JJ cord-023726-2fduzqyb 111 31 subunits subunit NNS cord-023726-2fduzqyb 111 32 . . . cord-023726-2fduzqyb 112 1 In in IN cord-023726-2fduzqyb 112 2 the the DT cord-023726-2fduzqyb 112 3 case case NN cord-023726-2fduzqyb 112 4 of of IN cord-023726-2fduzqyb 112 5 the the DT cord-023726-2fduzqyb 112 6 CC CC NNP cord-023726-2fduzqyb 112 7 dimers dimer NNS cord-023726-2fduzqyb 112 8 , , , cord-023726-2fduzqyb 112 9 the the DT cord-023726-2fduzqyb 112 10 connecting connect VBG cord-023726-2fduzqyb 112 11 arms arm NNS cord-023726-2fduzqyb 112 12 interdigitate interdigitate NNP cord-023726-2fduzqyb 112 13 with with IN cord-023726-2fduzqyb 112 14 two two CD cord-023726-2fduzqyb 112 15 others other NNS cord-023726-2fduzqyb 112 16 around around IN cord-023726-2fduzqyb 112 17 the the DT cord-023726-2fduzqyb 112 18 icosahedral icosahedral JJ cord-023726-2fduzqyb 112 19 threefold threefold JJ cord-023726-2fduzqyb 112 20 axis axis NN cord-023726-2fduzqyb 112 21 to to TO cord-023726-2fduzqyb 112 22 form form VB cord-023726-2fduzqyb 112 23 an an DT cord-023726-2fduzqyb 112 24 interconnected interconnected JJ cord-023726-2fduzqyb 112 25 internal internal JJ cord-023726-2fduzqyb 112 26 framework framework NN cord-023726-2fduzqyb 112 27 . . . cord-023726-2fduzqyb 113 1 In in IN cord-023726-2fduzqyb 113 2 the the DT cord-023726-2fduzqyb 113 3 case case NN cord-023726-2fduzqyb 113 4 of of IN cord-023726-2fduzqyb 113 5 the the DT cord-023726-2fduzqyb 113 6 AB AB NNP cord-023726-2fduzqyb 113 7 conformational conformational JJ cord-023726-2fduzqyb 113 8 dimer dimer NN cord-023726-2fduzqyb 113 9 , , , cord-023726-2fduzqyb 113 10 the the DT cord-023726-2fduzqyb 113 11 arms arm NNS cord-023726-2fduzqyb 113 12 are be VBP cord-023726-2fduzqyb 113 13 disordered disordered JJ cord-023726-2fduzqyb 113 14 , , , cord-023726-2fduzqyb 113 15 allowing allow VBG cord-023726-2fduzqyb 113 16 sharper sharp JJR cord-023726-2fduzqyb 113 17 curvature curvature NN cord-023726-2fduzqyb 113 18 . . . cord-023726-2fduzqyb 114 1 For for IN cord-023726-2fduzqyb 114 2 flock flock NN cord-023726-2fduzqyb 114 3 house house NN cord-023726-2fduzqyb 114 4 virus virus NN cord-023726-2fduzqyb 114 5 , , , cord-023726-2fduzqyb 114 6 the the DT cord-023726-2fduzqyb 114 7 RNA RNA NNP cord-023726-2fduzqyb 114 8 plays play VBZ cord-023726-2fduzqyb 114 9 a a DT cord-023726-2fduzqyb 114 10 role role NN cord-023726-2fduzqyb 114 11 in in IN cord-023726-2fduzqyb 114 12 controlling control VBG cord-023726-2fduzqyb 114 13 the the DT cord-023726-2fduzqyb 114 14 curvature curvature NN cord-023726-2fduzqyb 114 15 of of IN cord-023726-2fduzqyb 114 16 the the DT cord-023726-2fduzqyb 114 17 CC cc NN cord-023726-2fduzqyb 114 18 dimers dimer NNS cord-023726-2fduzqyb 114 19 , , , cord-023726-2fduzqyb 114 20 as as IN cord-023726-2fduzqyb 114 21 illustrated illustrate VBN cord-023726-2fduzqyb 114 22 in in IN cord-023726-2fduzqyb 114 23 Fig Fig NNP cord-023726-2fduzqyb 114 24 . . . cord-023726-2fduzqyb 115 1 2 2 LS cord-023726-2fduzqyb 115 2 .6 .6 NFP cord-023726-2fduzqyb 115 3 . . . cord-023726-2fduzqyb 116 1 B. B. NNP cord-023726-2fduzqyb 116 2 proteins protein NNS cord-023726-2fduzqyb 116 3 that that WDT cord-023726-2fduzqyb 116 4 make make VBP cord-023726-2fduzqyb 116 5 up up RP cord-023726-2fduzqyb 116 6 a a DT cord-023726-2fduzqyb 116 7 triangular triangular JJ cord-023726-2fduzqyb 116 8 face face NN cord-023726-2fduzqyb 116 9 are be VBP cord-023726-2fduzqyb 116 10 only only RB cord-023726-2fduzqyb 116 11 quasi quasi JJ cord-023726-2fduzqyb 116 12 - - JJ cord-023726-2fduzqyb 116 13 equivalent equivalent JJ cord-023726-2fduzqyb 116 14 . . . cord-023726-2fduzqyb 117 1 The the DT cord-023726-2fduzqyb 117 2 angle angle NN cord-023726-2fduzqyb 117 3 between between IN cord-023726-2fduzqyb 117 4 the the DT cord-023726-2fduzqyb 117 5 A a NN cord-023726-2fduzqyb 117 6 and and CC cord-023726-2fduzqyb 117 7 B b NN cord-023726-2fduzqyb 117 8 5 5 CD cord-023726-2fduzqyb 117 9 units unit NNS cord-023726-2fduzqyb 117 10 ( ( -LRB- cord-023726-2fduzqyb 117 11 shown show VBN cord-023726-2fduzqyb 117 12 with with IN cord-023726-2fduzqyb 117 13 a a DT cord-023726-2fduzqyb 117 14 red red JJ cord-023726-2fduzqyb 117 15 oval oval NN cord-023726-2fduzqyb 117 16 and and CC cord-023726-2fduzqyb 117 17 in in IN cord-023726-2fduzqyb 117 18 diagram diagram NN cord-023726-2fduzqyb 117 19 ( ( -LRB- cord-023726-2fduzqyb 117 20 C C NNP cord-023726-2fduzqyb 117 21 ) ) -RRB- cord-023726-2fduzqyb 117 22 is be VBZ cord-023726-2fduzqyb 117 23 more more RBR cord-023726-2fduzqyb 117 24 acute acute JJ cord-023726-2fduzqyb 117 25 than than IN cord-023726-2fduzqyb 117 26 that that DT cord-023726-2fduzqyb 117 27 along along IN cord-023726-2fduzqyb 117 28 the the DT cord-023726-2fduzqyb 117 29 C C NNP cord-023726-2fduzqyb 117 30 - - HYPH cord-023726-2fduzqyb 117 31 C C NNP cord-023726-2fduzqyb 117 32 2 2 CD cord-023726-2fduzqyb 117 33 edge edge NN cord-023726-2fduzqyb 117 34 , , , cord-023726-2fduzqyb 117 35 shown show VBN cord-023726-2fduzqyb 117 36 with with IN cord-023726-2fduzqyb 117 37 a a DT cord-023726-2fduzqyb 117 38 blue blue JJ cord-023726-2fduzqyb 117 39 oval oval NN cord-023726-2fduzqyb 117 40 , , , cord-023726-2fduzqyb 117 41 and and CC cord-023726-2fduzqyb 117 42 diagram diagram VB cord-023726-2fduzqyb 117 43 ( ( -LRB- cord-023726-2fduzqyb 117 44 B b NN cord-023726-2fduzqyb 117 45 ) ) -RRB- cord-023726-2fduzqyb 117 46 . . . cord-023726-2fduzqyb 118 1 This this DT cord-023726-2fduzqyb 118 2 difference difference NN cord-023726-2fduzqyb 118 3 in in IN cord-023726-2fduzqyb 118 4 the the DT cord-023726-2fduzqyb 118 5 angles angle NNS cord-023726-2fduzqyb 118 6 is be VBZ cord-023726-2fduzqyb 118 7 due due JJ cord-023726-2fduzqyb 118 8 to to IN cord-023726-2fduzqyb 118 9 the the DT cord-023726-2fduzqyb 118 10 presence presence NN cord-023726-2fduzqyb 118 11 of of IN cord-023726-2fduzqyb 118 12 an an DT cord-023726-2fduzqyb 118 13 RNA RNA NNP cord-023726-2fduzqyb 118 14 molecule molecule NN cord-023726-2fduzqyb 118 15 located locate VBN cord-023726-2fduzqyb 118 16 under under IN cord-023726-2fduzqyb 118 17 the the DT cord-023726-2fduzqyb 118 18 C C NNP cord-023726-2fduzqyb 118 19 - - HYPH cord-023726-2fduzqyb 118 20 C C NNP cord-023726-2fduzqyb 118 21 2 2 CD cord-023726-2fduzqyb 118 22 edge edge NN cord-023726-2fduzqyb 118 23 . . . cord-023726-2fduzqyb 119 1 From from IN cord-023726-2fduzqyb 119 2 Johnson Johnson NNP cord-023726-2fduzqyb 119 3 ( ( -LRB- cord-023726-2fduzqyb 119 4 1996 1996 CD cord-023726-2fduzqyb 119 5 ) ) -RRB- cord-023726-2fduzqyb 119 6 , , , cord-023726-2fduzqyb 119 7 with with IN cord-023726-2fduzqyb 119 8 permission permission NN cord-023726-2fduzqyb 119 9 . . . cord-023726-2fduzqyb 120 1 The the DT cord-023726-2fduzqyb 120 2 structures structure NNS cord-023726-2fduzqyb 120 3 of of IN cord-023726-2fduzqyb 120 4 several several JJ cord-023726-2fduzqyb 120 5 picornaviruses picornavirus NNS cord-023726-2fduzqyb 120 6 and and CC cord-023726-2fduzqyb 120 7 of of IN cord-023726-2fduzqyb 120 8 a a DT cord-023726-2fduzqyb 120 9 plant plant NN cord-023726-2fduzqyb 120 10 comovirus comovirus NNP cord-023726-2fduzqyb 120 11 ( ( -LRB- cord-023726-2fduzqyb 120 12 cowpea cowpea NNP cord-023726-2fduzqyb 120 13 mosaic mosaic NNP cord-023726-2fduzqyb 120 14 virus virus NN cord-023726-2fduzqyb 120 15 ) ) -RRB- cord-023726-2fduzqyb 120 16 have have VBP cord-023726-2fduzqyb 120 17 also also RB cord-023726-2fduzqyb 120 18 been be VBN cord-023726-2fduzqyb 120 19 solved solve VBN cord-023726-2fduzqyb 120 20 to to IN cord-023726-2fduzqyb 120 21 atomic atomic JJ cord-023726-2fduzqyb 120 22 resolution resolution NN cord-023726-2fduzqyb 120 23 . . . cord-023726-2fduzqyb 121 1 The the DT cord-023726-2fduzqyb 121 2 structures structure NNS cord-023726-2fduzqyb 121 3 of of IN cord-023726-2fduzqyb 121 4 these these DT cord-023726-2fduzqyb 121 5 viruses virus NNS cord-023726-2fduzqyb 121 6 are be VBP cord-023726-2fduzqyb 121 7 similar similar JJ cord-023726-2fduzqyb 121 8 to to IN cord-023726-2fduzqyb 121 9 those those DT cord-023726-2fduzqyb 121 10 of of IN cord-023726-2fduzqyb 121 11 the the DT cord-023726-2fduzqyb 121 12 plant plant NN cord-023726-2fduzqyb 121 13 T=3 T=3 NNP cord-023726-2fduzqyb 121 14 viruses virus NNS cord-023726-2fduzqyb 121 15 , , , cord-023726-2fduzqyb 121 16 but but CC cord-023726-2fduzqyb 121 17 the the DT cord-023726-2fduzqyb 121 18 180 180 CD cord-023726-2fduzqyb 121 19 subunits subunit NNS cord-023726-2fduzqyb 121 20 that that WDT cord-023726-2fduzqyb 121 21 form form VBP cord-023726-2fduzqyb 121 22 the the DT cord-023726-2fduzqyb 121 23 virion virion NN cord-023726-2fduzqyb 121 24 are be VBP cord-023726-2fduzqyb 121 25 not not RB cord-023726-2fduzqyb 121 26 all all RB cord-023726-2fduzqyb 121 27 identical identical JJ cord-023726-2fduzqyb 121 28 . . . cord-023726-2fduzqyb 122 1 A a DT cord-023726-2fduzqyb 122 2 comparison comparison NN cord-023726-2fduzqyb 122 3 of of IN cord-023726-2fduzqyb 122 4 the the DT cord-023726-2fduzqyb 122 5 structure structure NN cord-023726-2fduzqyb 122 6 of of IN cord-023726-2fduzqyb 122 7 a a DT cord-023726-2fduzqyb 122 8 T=3 T=3 NNP cord-023726-2fduzqyb 122 9 virus virus NN cord-023726-2fduzqyb 122 10 with with IN cord-023726-2fduzqyb 122 11 those those DT cord-023726-2fduzqyb 122 12 of of IN cord-023726-2fduzqyb 122 13 poliovirus poliovirus NN cord-023726-2fduzqyb 122 14 and and CC cord-023726-2fduzqyb 122 15 of of IN cord-023726-2fduzqyb 122 16 cowpea cowpea NNP cord-023726-2fduzqyb 122 17 mosaic mosaic NNP cord-023726-2fduzqyb 122 18 virus virus NN cord-023726-2fduzqyb 122 19 is be VBZ cord-023726-2fduzqyb 122 20 shown show VBN cord-023726-2fduzqyb 122 21 in in IN cord-023726-2fduzqyb 122 22 Fig Fig NNP cord-023726-2fduzqyb 122 23 . . . cord-023726-2fduzqyb 123 1 2 2 LS cord-023726-2fduzqyb 123 2 .7 .7 NFP cord-023726-2fduzqyb 123 3 . . . cord-023726-2fduzqyb 124 1 Poliovirus Poliovirus NNP cord-023726-2fduzqyb 124 2 has have VBZ cord-023726-2fduzqyb 124 3 60 60 CD cord-023726-2fduzqyb 124 4 copies copy NNS cord-023726-2fduzqyb 124 5 of of IN cord-023726-2fduzqyb 124 6 each each DT cord-023726-2fduzqyb 124 7 of of IN cord-023726-2fduzqyb 124 8 three three CD cord-023726-2fduzqyb 124 9 different different JJ cord-023726-2fduzqyb 124 10 proteins protein NNS cord-023726-2fduzqyb 124 11 , , , cord-023726-2fduzqyb 124 12 whereas whereas IN cord-023726-2fduzqyb 124 13 the the DT cord-023726-2fduzqyb 124 14 comovirus comovirus NN cord-023726-2fduzqyb 124 15 has have VBZ cord-023726-2fduzqyb 124 16 60 60 CD cord-023726-2fduzqyb 124 17 copies copy NNS cord-023726-2fduzqyb 124 18 of of IN cord-023726-2fduzqyb 124 19 an an DT cord-023726-2fduzqyb 124 20 L l NN cord-023726-2fduzqyb 124 21 protein protein NN cord-023726-2fduzqyb 124 22 ( ( -LRB- cord-023726-2fduzqyb 124 23 each each DT cord-023726-2fduzqyb 124 24 of of IN cord-023726-2fduzqyb 124 25 which which WDT cord-023726-2fduzqyb 124 26 fills fill VBZ cord-023726-2fduzqyb 124 27 the the DT cord-023726-2fduzqyb 124 28 niche niche NN cord-023726-2fduzqyb 124 29 of of IN cord-023726-2fduzqyb 124 30 two two CD cord-023726-2fduzqyb 124 31 units unit NNS cord-023726-2fduzqyb 124 32 ) ) -RRB- cord-023726-2fduzqyb 124 33 and and CC cord-023726-2fduzqyb 124 34 60 60 CD cord-023726-2fduzqyb 124 35 copies copy NNS cord-023726-2fduzqyb 124 36 of of IN cord-023726-2fduzqyb 124 37 an an DT cord-023726-2fduzqyb 124 38 S S NNP cord-023726-2fduzqyb 124 39 protein protein NN cord-023726-2fduzqyb 124 40 . . . cord-023726-2fduzqyb 125 1 All all DT cord-023726-2fduzqyb 125 2 three three CD cord-023726-2fduzqyb 125 3 poliovirus poliovirus NN cord-023726-2fduzqyb 125 4 capsid capsid NN cord-023726-2fduzqyb 125 5 proteins protein NNS cord-023726-2fduzqyb 125 6 have have VBP cord-023726-2fduzqyb 125 7 the the DT cord-023726-2fduzqyb 125 8 eight eight CD cord-023726-2fduzqyb 125 9 - - HYPH cord-023726-2fduzqyb 125 10 stranded stranded JJ cord-023726-2fduzqyb 125 11 antiparallel antiparallel IN cord-023726-2fduzqyb 125 12 β β NN cord-023726-2fduzqyb 125 13 - - HYPH cord-023726-2fduzqyb 125 14 sandwich sandwich NN cord-023726-2fduzqyb 125 15 fold fold NN cord-023726-2fduzqyb 125 16 . . . cord-023726-2fduzqyb 126 1 In in IN cord-023726-2fduzqyb 126 2 the the DT cord-023726-2fduzqyb 126 3 comoviruses comoviruse NNS cord-023726-2fduzqyb 126 4 , , , cord-023726-2fduzqyb 126 5 the the DT cord-023726-2fduzqyb 126 6 L L NNP cord-023726-2fduzqyb 126 7 protein protein NN cord-023726-2fduzqyb 126 8 has have VBZ cord-023726-2fduzqyb 126 9 two two CD cord-023726-2fduzqyb 126 10 β β NN cord-023726-2fduzqyb 126 11 - - HYPH cord-023726-2fduzqyb 126 12 sandwich sandwich NN cord-023726-2fduzqyb 126 13 structures structure NNS cord-023726-2fduzqyb 126 14 fused fuse VBN cord-023726-2fduzqyb 126 15 to to TO cord-023726-2fduzqyb 126 16 form form VB cord-023726-2fduzqyb 126 17 one one CD cord-023726-2fduzqyb 126 18 large large JJ cord-023726-2fduzqyb 126 19 protein protein NN cord-023726-2fduzqyb 126 20 , , , cord-023726-2fduzqyb 126 21 and and CC cord-023726-2fduzqyb 126 22 the the DT cord-023726-2fduzqyb 126 23 S S NNP cord-023726-2fduzqyb 126 24 protein protein NN cord-023726-2fduzqyb 126 25 is be VBZ cord-023726-2fduzqyb 126 26 formed form VBN cord-023726-2fduzqyb 126 27 from from IN cord-023726-2fduzqyb 126 28 one one CD cord-023726-2fduzqyb 126 29 sandwich sandwich NN cord-023726-2fduzqyb 126 30 . . . cord-023726-2fduzqyb 127 1 The the DT cord-023726-2fduzqyb 127 2 structures structure NNS cord-023726-2fduzqyb 127 3 of of IN cord-023726-2fduzqyb 127 4 the the DT cord-023726-2fduzqyb 127 5 picornavirus picornavirus NNP cord-023726-2fduzqyb 127 6 and and CC cord-023726-2fduzqyb 127 7 comovirus comovirus NNP cord-023726-2fduzqyb 127 8 virions virion NNS cord-023726-2fduzqyb 127 9 are be VBP cord-023726-2fduzqyb 127 10 called call VBN cord-023726-2fduzqyb 127 11 pseudo pseudo NNP cord-023726-2fduzqyb 127 12 - - HYPH cord-023726-2fduzqyb 127 13 T=3 T=3 NNP cord-023726-2fduzqyb 127 14 or or CC cord-023726-2fduzqyb 127 15 P=3 P=3 NNP cord-023726-2fduzqyb 127 16 , , , cord-023726-2fduzqyb 127 17 since since IN cord-023726-2fduzqyb 127 18 they -PRON- PRP cord-023726-2fduzqyb 127 19 are be VBP cord-023726-2fduzqyb 127 20 not not RB cord-023726-2fduzqyb 127 21 true true JJ cord-023726-2fduzqyb 127 22 T=3 T=3 NNP cord-023726-2fduzqyb 127 23 structures structure NNS cord-023726-2fduzqyb 127 24 . . . cord-023726-2fduzqyb 128 1 The the DT cord-023726-2fduzqyb 128 2 picornavirus picornavirus NN cord-023726-2fduzqyb 128 3 virion virion NN cord-023726-2fduzqyb 128 4 is be VBZ cord-023726-2fduzqyb 128 5 300 300 CD cord-023726-2fduzqyb 128 6 Å å NN cord-023726-2fduzqyb 128 7 in in IN cord-023726-2fduzqyb 128 8 diameter diameter NN cord-023726-2fduzqyb 128 9 . . . cord-023726-2fduzqyb 129 1 The the DT cord-023726-2fduzqyb 129 2 60 60 CD cord-023726-2fduzqyb 129 3 molecules molecule NNS cord-023726-2fduzqyb 129 4 of of IN cord-023726-2fduzqyb 129 5 each each DT cord-023726-2fduzqyb 129 6 of of IN cord-023726-2fduzqyb 129 7 the the DT cord-023726-2fduzqyb 129 8 three three CD cord-023726-2fduzqyb 129 9 different different JJ cord-023726-2fduzqyb 129 10 proteins protein NNS cord-023726-2fduzqyb 129 11 have have VBP cord-023726-2fduzqyb 129 12 different different JJ cord-023726-2fduzqyb 129 13 roles role NNS cord-023726-2fduzqyb 129 14 in in IN cord-023726-2fduzqyb 129 15 the the DT cord-023726-2fduzqyb 129 16 final final JJ cord-023726-2fduzqyb 129 17 structure structure NN cord-023726-2fduzqyb 129 18 , , , cord-023726-2fduzqyb 129 19 as as IN cord-023726-2fduzqyb 129 20 illustrated illustrate VBN cord-023726-2fduzqyb 129 21 in in IN cord-023726-2fduzqyb 129 22 Fig Fig NNP cord-023726-2fduzqyb 129 23 . . . cord-023726-2fduzqyb 130 1 2 2 LS cord-023726-2fduzqyb 130 2 .8 .8 CD cord-023726-2fduzqyb 130 3 , , , cord-023726-2fduzqyb 130 4 in in IN cord-023726-2fduzqyb 130 5 which which WDT cord-023726-2fduzqyb 130 6 the the DT cord-023726-2fduzqyb 130 7 structure structure NN cord-023726-2fduzqyb 130 8 of of IN cord-023726-2fduzqyb 130 9 a a DT cord-023726-2fduzqyb 130 10 rhinovirus rhinovirus NN cord-023726-2fduzqyb 130 11 is be VBZ cord-023726-2fduzqyb 130 12 shown show VBN cord-023726-2fduzqyb 130 13 . . . cord-023726-2fduzqyb 131 1 Notice notice VB cord-023726-2fduzqyb 131 2 that that IN cord-023726-2fduzqyb 131 3 five five CD cord-023726-2fduzqyb 131 4 copies copy NNS cord-023726-2fduzqyb 131 5 of of IN cord-023726-2fduzqyb 131 6 VP1 VP1 NNP cord-023726-2fduzqyb 131 7 are be VBP cord-023726-2fduzqyb 131 8 found find VBN cord-023726-2fduzqyb 131 9 at at IN cord-023726-2fduzqyb 131 10 each each DT cord-023726-2fduzqyb 131 11 fivefold fivefold JJ cord-023726-2fduzqyb 131 12 axis axis NN cord-023726-2fduzqyb 131 13 ( ( -LRB- cord-023726-2fduzqyb 131 14 compare compare VB cord-023726-2fduzqyb 131 15 Fig Fig NNP cord-023726-2fduzqyb 131 16 . . . cord-023726-2fduzqyb 132 1 2 2 LS cord-023726-2fduzqyb 132 2 .7 .7 . cord-023726-2fduzqyb 133 1 with with IN cord-023726-2fduzqyb 133 2 Fig Fig NNP cord-023726-2fduzqyb 133 3 . . . cord-023726-2fduzqyb 133 4 2.8 2.8 CD cord-023726-2fduzqyb 133 5 ) ) -RRB- cord-023726-2fduzqyb 133 6 . . . cord-023726-2fduzqyb 134 1 VP1 VP1 NNP cord-023726-2fduzqyb 134 2 , , , cord-023726-2fduzqyb 134 3 VP2 vp2 NN cord-023726-2fduzqyb 134 4 , , , cord-023726-2fduzqyb 134 5 and and CC cord-023726-2fduzqyb 134 6 VP3 VP3 NNP cord-023726-2fduzqyb 134 7 are be VBP cord-023726-2fduzqyb 134 8 structurally structurally RB cord-023726-2fduzqyb 134 9 related relate VBN cord-023726-2fduzqyb 134 10 to to IN cord-023726-2fduzqyb 134 11 one one CD cord-023726-2fduzqyb 134 12 another another DT cord-023726-2fduzqyb 134 13 , , , cord-023726-2fduzqyb 134 14 as as IN cord-023726-2fduzqyb 134 15 stated state VBN cord-023726-2fduzqyb 134 16 , , , cord-023726-2fduzqyb 134 17 all all DT cord-023726-2fduzqyb 134 18 possessing possess VBG cord-023726-2fduzqyb 134 19 the the DT cord-023726-2fduzqyb 134 20 common common JJ cord-023726-2fduzqyb 134 21 βsandwich βsandwich NN cord-023726-2fduzqyb 134 22 fold fold VB cord-023726-2fduzqyb 134 23 . . . cord-023726-2fduzqyb 135 1 There there EX cord-023726-2fduzqyb 135 2 exists exist VBZ cord-023726-2fduzqyb 135 3 a a DT cord-023726-2fduzqyb 135 4 depression depression NN cord-023726-2fduzqyb 135 5 around around IN cord-023726-2fduzqyb 135 6 each each DT cord-023726-2fduzqyb 135 7 fivefold fivefold JJ cord-023726-2fduzqyb 135 8 axis axis NN cord-023726-2fduzqyb 135 9 of of IN cord-023726-2fduzqyb 135 10 rhinoviruses rhinovirus NNS cord-023726-2fduzqyb 135 11 that that WDT cord-023726-2fduzqyb 135 12 has have VBZ cord-023726-2fduzqyb 135 13 been be VBN cord-023726-2fduzqyb 135 14 termed term VBN cord-023726-2fduzqyb 135 15 a a DT cord-023726-2fduzqyb 135 16 " " `` cord-023726-2fduzqyb 135 17 canyon canyon NN cord-023726-2fduzqyb 135 18 . . . cord-023726-2fduzqyb 136 1 " " `` cord-023726-2fduzqyb 136 2 This this DT cord-023726-2fduzqyb 136 3 depression depression NN cord-023726-2fduzqyb 136 4 is be VBZ cord-023726-2fduzqyb 136 5 believed believe VBN cord-023726-2fduzqyb 136 6 to to TO cord-023726-2fduzqyb 136 7 be be VB cord-023726-2fduzqyb 136 8 the the DT cord-023726-2fduzqyb 136 9 site site NN cord-023726-2fduzqyb 136 10 at at IN cord-023726-2fduzqyb 136 11 which which WDT cord-023726-2fduzqyb 136 12 the the DT cord-023726-2fduzqyb 136 13 virus virus NN cord-023726-2fduzqyb 136 14 interacts interact VBZ cord-023726-2fduzqyb 136 15 with with IN cord-023726-2fduzqyb 136 16 the the DT cord-023726-2fduzqyb 136 17 cellular cellular JJ cord-023726-2fduzqyb 136 18 receptor receptor NN cord-023726-2fduzqyb 136 19 during during IN cord-023726-2fduzqyb 136 20 entry entry NN cord-023726-2fduzqyb 136 21 , , , cord-023726-2fduzqyb 136 22 as as IN cord-023726-2fduzqyb 136 23 illustrated illustrate VBN cord-023726-2fduzqyb 136 24 in in IN cord-023726-2fduzqyb 136 25 Fig Fig NNP cord-023726-2fduzqyb 136 26 . . . cord-023726-2fduzqyb 137 1 2 2 LS cord-023726-2fduzqyb 137 2 .9 .9 CD cord-023726-2fduzqyb 137 3 . . . cord-023726-2fduzqyb 138 1 This this DT cord-023726-2fduzqyb 138 2 interaction interaction NN cord-023726-2fduzqyb 138 3 is be VBZ cord-023726-2fduzqyb 138 4 thought think VBN cord-023726-2fduzqyb 138 5 to to TO cord-023726-2fduzqyb 138 6 lead lead VB cord-023726-2fduzqyb 138 7 to to IN cord-023726-2fduzqyb 138 8 conformational conformational JJ cord-023726-2fduzqyb 138 9 changes change NNS cord-023726-2fduzqyb 138 10 that that WDT cord-023726-2fduzqyb 138 11 open open VBP cord-023726-2fduzqyb 138 12 a a DT cord-023726-2fduzqyb 138 13 channel channel NN cord-023726-2fduzqyb 138 14 at at IN cord-023726-2fduzqyb 138 15 the the DT cord-023726-2fduzqyb 138 16 fivefold fivefold JJ cord-023726-2fduzqyb 138 17 axis axis NN cord-023726-2fduzqyb 138 18 , , , cord-023726-2fduzqyb 138 19 through through IN cord-023726-2fduzqyb 138 20 which which WDT cord-023726-2fduzqyb 138 21 VP4 VP4 NNP cord-023726-2fduzqyb 138 22 is be VBZ cord-023726-2fduzqyb 138 23 extruded extrude VBN cord-023726-2fduzqyb 138 24 , , , cord-023726-2fduzqyb 138 25 followed follow VBN cord-023726-2fduzqyb 138 26 by by IN cord-023726-2fduzqyb 138 27 the the DT cord-023726-2fduzqyb 138 28 viral viral JJ cord-023726-2fduzqyb 138 29 RNA RNA NNP cord-023726-2fduzqyb 138 30 . . . cord-023726-2fduzqyb 139 1 The the DT cord-023726-2fduzqyb 139 2 structures structure NNS cord-023726-2fduzqyb 139 3 of of IN cord-023726-2fduzqyb 139 4 both both DT cord-023726-2fduzqyb 139 5 mouse mouse NN cord-023726-2fduzqyb 139 6 polyomavirus polyomavirus NNP cord-023726-2fduzqyb 139 7 and and CC cord-023726-2fduzqyb 139 8 of of IN cord-023726-2fduzqyb 139 9 SV40 SV40 NNP cord-023726-2fduzqyb 139 10 virus virus NN cord-023726-2fduzqyb 139 11 , , , cord-023726-2fduzqyb 139 12 two two CD cord-023726-2fduzqyb 139 13 members member NNS cord-023726-2fduzqyb 139 14 of of IN cord-023726-2fduzqyb 139 15 the the DT cord-023726-2fduzqyb 139 16 family family NN cord-023726-2fduzqyb 139 17 Polyomaviridae Polyomaviridae NNP cord-023726-2fduzqyb 139 18 , , , cord-023726-2fduzqyb 139 19 have have VBP cord-023726-2fduzqyb 139 20 been be VBN cord-023726-2fduzqyb 139 21 solved solve VBN cord-023726-2fduzqyb 139 22 to to IN cord-023726-2fduzqyb 139 23 atomic atomic JJ cord-023726-2fduzqyb 139 24 resolution resolution NN cord-023726-2fduzqyb 139 25 . . . cord-023726-2fduzqyb 140 1 Both both DT cord-023726-2fduzqyb 140 2 viruses virus NNS cord-023726-2fduzqyb 140 3 possess possess VBP cord-023726-2fduzqyb 140 4 pseudo pseudo JJ cord-023726-2fduzqyb 140 5 - - HYPH cord-023726-2fduzqyb 140 6 T=7 T=7 NNP cord-023726-2fduzqyb 140 7 icosahedral icosahedral JJ cord-023726-2fduzqyb 140 8 symmetry symmetry NN cord-023726-2fduzqyb 140 9 . . . cord-023726-2fduzqyb 141 1 Although although IN cord-023726-2fduzqyb 141 2 T=7 T=7 NNP cord-023726-2fduzqyb 141 3 _SP cord-023726-2fduzqyb 141 4 L L NNP cord-023726-2fduzqyb 141 5 VP1 VP1 NNP cord-023726-2fduzqyb 141 6 VP2 VP2 NNP cord-023726-2fduzqyb 141 7 VP3 VP3 NNP cord-023726-2fduzqyb 141 8 VP1 VP1 NNP cord-023726-2fduzqyb 141 9 VP2 VP2 NNP cord-023726-2fduzqyb 141 10 VP1 VP1 NNP cord-023726-2fduzqyb 141 11 VP2 VP2 NNP cord-023726-2fduzqyb 141 12 VP3 VP3 NNP cord-023726-2fduzqyb 141 13 VP1 VP1 NNP cord-023726-2fduzqyb 141 14 VP2 VP2 NNP cord-023726-2fduzqyb 141 15 VP3 VP3 NNP cord-023726-2fduzqyb 141 16 VP1 VP1 NNP cord-023726-2fduzqyb 141 17 VP2 VP2 NNP cord-023726-2fduzqyb 141 18 VP3 VP3 NNP cord-023726-2fduzqyb 141 19 VP1 VP1 NNP cord-023726-2fduzqyb 141 20 VP2 VP2 NNP cord-023726-2fduzqyb 141 21 VP3 VP3 NNP cord-023726-2fduzqyb 141 22 VP1 VP1 NNP cord-023726-2fduzqyb 141 23 VP2 VP2 NNP cord-023726-2fduzqyb 141 24 VP3 VP3 NNP cord-023726-2fduzqyb 141 25 VP1 VP1 NNP cord-023726-2fduzqyb 141 26 VP2 VP2 NNP cord-023726-2fduzqyb 141 27 VP3 VP3 NNP cord-023726-2fduzqyb 141 28 VP1 VP1 NNP cord-023726-2fduzqyb 141 29 VP2 VP2 NNP cord-023726-2fduzqyb 141 30 VP3 VP3 NNP cord-023726-2fduzqyb 141 31 VP1 VP1 NNP cord-023726-2fduzqyb 141 32 VP2 VP2 NNP cord-023726-2fduzqyb 141 33 VP3 VP3 NNP cord-023726-2fduzqyb 141 34 VP1 VP1 NNP cord-023726-2fduzqyb 141 35 VP2 VP2 NNP cord-023726-2fduzqyb 141 36 VP3 VP3 NNP cord-023726-2fduzqyb 141 37 VP1 VP1 NNP cord-023726-2fduzqyb 141 38 VP2 vp2 NN cord-023726-2fduzqyb 141 39 VP3 VP3 NNP cord-023726-2fduzqyb 141 40 VP3 VP3 NNP cord-023726-2fduzqyb 141 41 FIGURE FIGURE NNP cord-023726-2fduzqyb 141 42 2.7 2.7 CD cord-023726-2fduzqyb 141 43 Arrangement Arrangement NNP cord-023726-2fduzqyb 141 44 of of IN cord-023726-2fduzqyb 141 45 the the DT cord-023726-2fduzqyb 141 46 coat coat NN cord-023726-2fduzqyb 141 47 protein protein NN cord-023726-2fduzqyb 141 48 subunits subunit NNS cord-023726-2fduzqyb 141 49 of of IN cord-023726-2fduzqyb 141 50 comoviruses comoviruse NNS cord-023726-2fduzqyb 141 51 compared compare VBN cord-023726-2fduzqyb 141 52 with with IN cord-023726-2fduzqyb 141 53 those those DT cord-023726-2fduzqyb 141 54 of of IN cord-023726-2fduzqyb 141 55 simple simple JJ cord-023726-2fduzqyb 141 56 T=3 T=3 NNP cord-023726-2fduzqyb 141 57 viruses virus NNS cord-023726-2fduzqyb 141 58 and and CC cord-023726-2fduzqyb 141 59 picornaviruses picornavirus NNS cord-023726-2fduzqyb 141 60 . . . cord-023726-2fduzqyb 142 1 In in IN cord-023726-2fduzqyb 142 2 simple simple JJ cord-023726-2fduzqyb 142 3 viruses virus NNS cord-023726-2fduzqyb 142 4 , , , cord-023726-2fduzqyb 142 5 the the DT cord-023726-2fduzqyb 142 6 asymmetric asymmetric JJ cord-023726-2fduzqyb 142 7 unit unit NN cord-023726-2fduzqyb 142 8 contains contain VBZ cord-023726-2fduzqyb 142 9 three three CD cord-023726-2fduzqyb 142 10 copies copy NNS cord-023726-2fduzqyb 142 11 of of IN cord-023726-2fduzqyb 142 12 a a DT cord-023726-2fduzqyb 142 13 single single JJ cord-023726-2fduzqyb 142 14 protein protein NN cord-023726-2fduzqyb 142 15 β β NN cord-023726-2fduzqyb 142 16 sandwich sandwich NN cord-023726-2fduzqyb 142 17 , , , cord-023726-2fduzqyb 142 18 labeled label VBD cord-023726-2fduzqyb 142 19 A A NNP cord-023726-2fduzqyb 142 20 , , , cord-023726-2fduzqyb 142 21 B b NN cord-023726-2fduzqyb 142 22 , , , cord-023726-2fduzqyb 142 23 and and CC cord-023726-2fduzqyb 142 24 C c NN cord-023726-2fduzqyb 142 25 in in IN cord-023726-2fduzqyb 142 26 order order NN cord-023726-2fduzqyb 142 27 to to TO cord-023726-2fduzqyb 142 28 distinguish distinguish VB cord-023726-2fduzqyb 142 29 them -PRON- PRP cord-023726-2fduzqyb 142 30 . . . cord-023726-2fduzqyb 143 1 In in IN cord-023726-2fduzqyb 143 2 picornaviruses picornavirus NNS cord-023726-2fduzqyb 143 3 such such JJ cord-023726-2fduzqyb 143 4 as as IN cord-023726-2fduzqyb 143 5 poliovirus poliovirus NN cord-023726-2fduzqyb 143 6 the the DT cord-023726-2fduzqyb 143 7 asymmetric asymmetric JJ cord-023726-2fduzqyb 143 8 unit unit NN cord-023726-2fduzqyb 143 9 is be VBZ cord-023726-2fduzqyb 143 10 made make VBN cord-023726-2fduzqyb 143 11 up up RP cord-023726-2fduzqyb 143 12 of of IN cord-023726-2fduzqyb 143 13 three three CD cord-023726-2fduzqyb 143 14 similar similar JJ cord-023726-2fduzqyb 143 15 but but CC cord-023726-2fduzqyb 143 16 not not RB cord-023726-2fduzqyb 143 17 identical identical JJ cord-023726-2fduzqyb 143 18 proteins protein NNS cord-023726-2fduzqyb 143 19 , , , cord-023726-2fduzqyb 143 20 all all DT cord-023726-2fduzqyb 143 21 of of IN cord-023726-2fduzqyb 143 22 which which WDT cord-023726-2fduzqyb 143 23 have have VBP cord-023726-2fduzqyb 143 24 the the DT cord-023726-2fduzqyb 143 25 β β NN cord-023726-2fduzqyb 143 26 - - HYPH cord-023726-2fduzqyb 143 27 sandwich sandwich NN cord-023726-2fduzqyb 143 28 structure structure NN cord-023726-2fduzqyb 143 29 . . . cord-023726-2fduzqyb 144 1 In in IN cord-023726-2fduzqyb 144 2 comoviruses comoviruse NNS cord-023726-2fduzqyb 144 3 such such JJ cord-023726-2fduzqyb 144 4 as as IN cord-023726-2fduzqyb 144 5 cowpea cowpea NNP cord-023726-2fduzqyb 144 6 mosaic mosaic NNP cord-023726-2fduzqyb 144 7 virus virus NN cord-023726-2fduzqyb 144 8 , , , cord-023726-2fduzqyb 144 9 two two CD cord-023726-2fduzqyb 144 10 of of IN cord-023726-2fduzqyb 144 11 the the DT cord-023726-2fduzqyb 144 12 β β NN cord-023726-2fduzqyb 144 13 - - HYPH cord-023726-2fduzqyb 144 14 sandwich sandwich NN cord-023726-2fduzqyb 144 15 subunits subunit NNS cord-023726-2fduzqyb 144 16 are be VBP cord-023726-2fduzqyb 144 17 fused fuse VBN cord-023726-2fduzqyb 144 18 to to TO cord-023726-2fduzqyb 144 19 give give VB cord-023726-2fduzqyb 144 20 the the DT cord-023726-2fduzqyb 144 21 L L NNP cord-023726-2fduzqyb 144 22 protein protein NN cord-023726-2fduzqyb 144 23 . . . cord-023726-2fduzqyb 145 1 Adapted adapt VBN cord-023726-2fduzqyb 145 2 from from IN cord-023726-2fduzqyb 145 3 Granoff Granoff NNP cord-023726-2fduzqyb 145 4 and and CC cord-023726-2fduzqyb 145 5 Webster Webster NNP cord-023726-2fduzqyb 145 6 ( ( -LRB- cord-023726-2fduzqyb 145 7 1999 1999 CD cord-023726-2fduzqyb 145 8 ) ) -RRB- cord-023726-2fduzqyb 145 9 , , , cord-023726-2fduzqyb 145 10 p. p. NN cord-023726-2fduzqyb 145 11 287 287 CD cord-023726-2fduzqyb 145 12 . . . cord-023726-2fduzqyb 146 1 symmetry symmetry NNP cord-023726-2fduzqyb 146 2 would would MD cord-023726-2fduzqyb 146 3 require require VB cord-023726-2fduzqyb 146 4 420 420 CD cord-023726-2fduzqyb 146 5 subunits subunit NNS cord-023726-2fduzqyb 146 6 , , , cord-023726-2fduzqyb 146 7 these these DT cord-023726-2fduzqyb 146 8 viruses virus NNS cord-023726-2fduzqyb 146 9 contain contain VBP cord-023726-2fduzqyb 146 10 only only RB cord-023726-2fduzqyb 146 11 360 360 CD cord-023726-2fduzqyb 146 12 copies copy NNS cord-023726-2fduzqyb 146 13 of of IN cord-023726-2fduzqyb 146 14 a a DT cord-023726-2fduzqyb 146 15 major major JJ cord-023726-2fduzqyb 146 16 structural structural JJ cord-023726-2fduzqyb 146 17 protein protein NN cord-023726-2fduzqyb 146 18 known know VBN cord-023726-2fduzqyb 146 19 as as IN cord-023726-2fduzqyb 146 20 VP1 VP1 NNP cord-023726-2fduzqyb 146 21 . . . cord-023726-2fduzqyb 147 1 These these DT cord-023726-2fduzqyb 147 2 360 360 CD cord-023726-2fduzqyb 147 3 copies copy NNS cord-023726-2fduzqyb 147 4 are be VBP cord-023726-2fduzqyb 147 5 assembled assemble VBN cord-023726-2fduzqyb 147 6 as as IN cord-023726-2fduzqyb 147 7 72 72 CD cord-023726-2fduzqyb 147 8 pentamers pentamer NNS cord-023726-2fduzqyb 147 9 . . . cord-023726-2fduzqyb 148 1 Twelve twelve CD cord-023726-2fduzqyb 148 2 of of IN cord-023726-2fduzqyb 148 3 the the DT cord-023726-2fduzqyb 148 4 72 72 CD cord-023726-2fduzqyb 148 5 pentamers pentamer NNS cord-023726-2fduzqyb 148 6 lie lie VBP cord-023726-2fduzqyb 148 7 on on IN cord-023726-2fduzqyb 148 8 the the DT cord-023726-2fduzqyb 148 9 fivefold fivefold JJ cord-023726-2fduzqyb 148 10 axes axis NNS cord-023726-2fduzqyb 148 11 and and CC cord-023726-2fduzqyb 148 12 the the DT cord-023726-2fduzqyb 148 13 remaining remain VBG cord-023726-2fduzqyb 148 14 60 60 CD cord-023726-2fduzqyb 148 15 fill fill NN cord-023726-2fduzqyb 148 16 the the DT cord-023726-2fduzqyb 148 17 intervening intervene VBG cord-023726-2fduzqyb 148 18 surface surface NN cord-023726-2fduzqyb 148 19 in in IN cord-023726-2fduzqyb 148 20 a a DT cord-023726-2fduzqyb 148 21 closely closely RB cord-023726-2fduzqyb 148 22 packed pack VBN cord-023726-2fduzqyb 148 23 array array NN cord-023726-2fduzqyb 148 24 ( ( -LRB- cord-023726-2fduzqyb 148 25 Fig fig NN cord-023726-2fduzqyb 148 26 . . NNP cord-023726-2fduzqyb 148 27 2 2 CD cord-023726-2fduzqyb 148 28 .10 .10 CD cord-023726-2fduzqyb 148 29 ) ) -RRB- cord-023726-2fduzqyb 148 30 . . . cord-023726-2fduzqyb 149 1 These these DT cord-023726-2fduzqyb 149 2 latter latter JJ cord-023726-2fduzqyb 149 3 pentamers pentamer NNS cord-023726-2fduzqyb 149 4 are be VBP cord-023726-2fduzqyb 149 5 thus thus RB cord-023726-2fduzqyb 149 6 sixfold sixfold RB cord-023726-2fduzqyb 149 7 coordinated coordinate VBN cord-023726-2fduzqyb 149 8 and and CC cord-023726-2fduzqyb 149 9 the the DT cord-023726-2fduzqyb 149 10 proteins protein NNS cord-023726-2fduzqyb 149 11 in in IN cord-023726-2fduzqyb 149 12 the the DT cord-023726-2fduzqyb 149 13 shell shell NN cord-023726-2fduzqyb 149 14 are be VBP cord-023726-2fduzqyb 149 15 not not RB cord-023726-2fduzqyb 149 16 all all DT cord-023726-2fduzqyb 149 17 in in IN cord-023726-2fduzqyb 149 18 quasi quasi JJ cord-023726-2fduzqyb 149 19 - - JJ cord-023726-2fduzqyb 149 20 equivalent equivalent JJ cord-023726-2fduzqyb 149 21 positions position NNS cord-023726-2fduzqyb 149 22 , , , cord-023726-2fduzqyb 149 23 a a DT cord-023726-2fduzqyb 149 24 surprising surprising JJ cord-023726-2fduzqyb 149 25 finding finding NN cord-023726-2fduzqyb 149 26 for for IN cord-023726-2fduzqyb 149 27 our -PRON- PRP$ cord-023726-2fduzqyb 149 28 understanding understanding NN cord-023726-2fduzqyb 149 29 of of IN cord-023726-2fduzqyb 149 30 the the DT cord-023726-2fduzqyb 149 31 principles principle NNS cord-023726-2fduzqyb 149 32 by by IN cord-023726-2fduzqyb 149 33 which which WDT cord-023726-2fduzqyb 149 34 viruses virus NNS cord-023726-2fduzqyb 149 35 can can MD cord-023726-2fduzqyb 149 36 be be VB cord-023726-2fduzqyb 149 37 constructed construct VBN cord-023726-2fduzqyb 149 38 . . . cord-023726-2fduzqyb 150 1 The the DT cord-023726-2fduzqyb 150 2 pentamers pentamer NNS cord-023726-2fduzqyb 150 3 are be VBP cord-023726-2fduzqyb 150 4 stabilized stabilize VBN cord-023726-2fduzqyb 150 5 by by IN cord-023726-2fduzqyb 150 6 interactions interaction NNS cord-023726-2fduzqyb 150 7 of of IN cord-023726-2fduzqyb 150 8 the the DT cord-023726-2fduzqyb 150 9 β β NN cord-023726-2fduzqyb 150 10 sheets sheet NNS cord-023726-2fduzqyb 150 11 between between IN cord-023726-2fduzqyb 150 12 adjacent adjacent JJ cord-023726-2fduzqyb 150 13 monomers monomer NNS cord-023726-2fduzqyb 150 14 in in IN cord-023726-2fduzqyb 150 15 a a DT cord-023726-2fduzqyb 150 16 pentamer pentamer NN cord-023726-2fduzqyb 151 1 ( ( -LRB- cord-023726-2fduzqyb 151 2 Fig Fig NNP cord-023726-2fduzqyb 151 3 . . NNP cord-023726-2fduzqyb 151 4 2.10C 2.10c CD cord-023726-2fduzqyb 151 5 ) ) -RRB- cord-023726-2fduzqyb 151 6 . . . cord-023726-2fduzqyb 152 1 The the DT cord-023726-2fduzqyb 152 2 pentamers pentamer NNS cord-023726-2fduzqyb 152 3 are be VBP cord-023726-2fduzqyb 152 4 then then RB cord-023726-2fduzqyb 152 5 tied tie VBN cord-023726-2fduzqyb 152 6 together together RB cord-023726-2fduzqyb 152 7 by by IN cord-023726-2fduzqyb 152 8 C c NN cord-023726-2fduzqyb 152 9 - - HYPH cord-023726-2fduzqyb 152 10 terminal terminal NN cord-023726-2fduzqyb 152 11 arms arm NNS cord-023726-2fduzqyb 152 12 of of IN cord-023726-2fduzqyb 152 13 VP1 vp1 NN cord-023726-2fduzqyb 152 14 that that WDT cord-023726-2fduzqyb 152 15 invade invade VBP cord-023726-2fduzqyb 152 16 monomers monomer NNS cord-023726-2fduzqyb 152 17 in in IN cord-023726-2fduzqyb 152 18 an an DT cord-023726-2fduzqyb 152 19 adjacent adjacent JJ cord-023726-2fduzqyb 152 20 pentamer pentamer NN cord-023726-2fduzqyb 152 21 ( ( -LRB- cord-023726-2fduzqyb 152 22 Figs Figs NNP cord-023726-2fduzqyb 152 23 . . . cord-023726-2fduzqyb 152 24 2.10B 2.10B NNP cord-023726-2fduzqyb 152 25 and and CC cord-023726-2fduzqyb 152 26 C C NNP cord-023726-2fduzqyb 152 27 ) ) -RRB- cord-023726-2fduzqyb 152 28 . . . cord-023726-2fduzqyb 153 1 Because because IN cord-023726-2fduzqyb 153 2 each each DT cord-023726-2fduzqyb 153 3 pentamer pentamer NN cord-023726-2fduzqyb 153 4 that that WDT cord-023726-2fduzqyb 153 5 is be VBZ cord-023726-2fduzqyb 153 6 sixfold sixfold RB cord-023726-2fduzqyb 153 7 coordinated coordinate VBN cord-023726-2fduzqyb 153 8 has have VBZ cord-023726-2fduzqyb 153 9 five five CD cord-023726-2fduzqyb 153 10 C c NN cord-023726-2fduzqyb 153 11 - - HYPH cord-023726-2fduzqyb 153 12 terminal terminal NN cord-023726-2fduzqyb 153 13 arms arm NNS cord-023726-2fduzqyb 153 14 to to TO cord-023726-2fduzqyb 153 15 interact interact VB cord-023726-2fduzqyb 153 16 with with IN cord-023726-2fduzqyb 153 17 six six CD cord-023726-2fduzqyb 153 18 neighboring neighbor VBG cord-023726-2fduzqyb 153 19 pentamers pentamer NNS cord-023726-2fduzqyb 153 20 , , , cord-023726-2fduzqyb 153 21 the the DT cord-023726-2fduzqyb 153 22 interactions interaction NNS cord-023726-2fduzqyb 153 23 between between IN cord-023726-2fduzqyb 153 24 monomers monomer NNS cord-023726-2fduzqyb 153 25 in in IN cord-023726-2fduzqyb 153 26 different different JJ cord-023726-2fduzqyb 153 27 pentamers pentamer NNS cord-023726-2fduzqyb 153 28 are be VBP cord-023726-2fduzqyb 153 29 not not RB cord-023726-2fduzqyb 153 30 all all RB cord-023726-2fduzqyb 153 31 identical identical JJ cord-023726-2fduzqyb 153 32 ( ( -LRB- cord-023726-2fduzqyb 153 33 Fig fig NN cord-023726-2fduzqyb 153 34 . . . cord-023726-2fduzqyb 153 35 2.10B 2.10B NNP cord-023726-2fduzqyb 153 36 ) ) -RRB- cord-023726-2fduzqyb 153 37 . . . cord-023726-2fduzqyb 154 1 Flexibility flexibility NN cord-023726-2fduzqyb 154 2 in in IN cord-023726-2fduzqyb 154 3 the the DT cord-023726-2fduzqyb 154 4 C C NNP cord-023726-2fduzqyb 154 5 - - HYPH cord-023726-2fduzqyb 154 6 terminal terminal NN cord-023726-2fduzqyb 154 7 arm arm NN cord-023726-2fduzqyb 154 8 allows allow VBZ cord-023726-2fduzqyb 154 9 it -PRON- PRP cord-023726-2fduzqyb 154 10 to to TO cord-023726-2fduzqyb 154 11 form form VB cord-023726-2fduzqyb 154 12 contacts contact NNS cord-023726-2fduzqyb 154 13 in in IN cord-023726-2fduzqyb 154 14 different different JJ cord-023726-2fduzqyb 154 15 ways way NNS cord-023726-2fduzqyb 154 16 . . . cord-023726-2fduzqyb 155 1 Members member NNS cord-023726-2fduzqyb 155 2 of of IN cord-023726-2fduzqyb 155 3 the the DT cord-023726-2fduzqyb 155 4 reovirus reovirus NNP cord-023726-2fduzqyb 155 5 family family NN cord-023726-2fduzqyb 155 6 are be VBP cord-023726-2fduzqyb 155 7 regular regular JJ cord-023726-2fduzqyb 155 8 T=13 t=13 JJ cord-023726-2fduzqyb 155 9 icosahedral icosahedral JJ cord-023726-2fduzqyb 155 10 particles particle NNS cord-023726-2fduzqyb 155 11 . . . cord-023726-2fduzqyb 156 1 They -PRON- PRP cord-023726-2fduzqyb 156 2 are be VBP cord-023726-2fduzqyb 156 3 composed compose VBN cord-023726-2fduzqyb 156 4 of of IN cord-023726-2fduzqyb 156 5 two two CD cord-023726-2fduzqyb 156 6 or or CC cord-023726-2fduzqyb 156 7 three three CD cord-023726-2fduzqyb 156 8 concentric concentric JJ cord-023726-2fduzqyb 156 9 protein protein NN cord-023726-2fduzqyb 156 10 shells shell NNS cord-023726-2fduzqyb 156 11 . . . cord-023726-2fduzqyb 157 1 Cryoelectron Cryoelectron NNP cord-023726-2fduzqyb 157 2 microscopy microscopy NN cord-023726-2fduzqyb 157 3 has have VBZ cord-023726-2fduzqyb 157 4 been be VBN cord-023726-2fduzqyb 157 5 used use VBN cord-023726-2fduzqyb 157 6 to to TO cord-023726-2fduzqyb 157 7 solve solve VB cord-023726-2fduzqyb 157 8 the the DT cord-023726-2fduzqyb 157 9 structure structure NN cord-023726-2fduzqyb 157 10 of of IN cord-023726-2fduzqyb 157 11 one one CD cord-023726-2fduzqyb 157 12 or or CC cord-023726-2fduzqyb 157 13 more more JJR cord-023726-2fduzqyb 157 14 members member NNS cord-023726-2fduzqyb 157 15 of of IN cord-023726-2fduzqyb 157 16 three three CD cord-023726-2fduzqyb 157 17 genera genus NNS cord-023726-2fduzqyb 157 18 within within IN cord-023726-2fduzqyb 157 19 the the DT cord-023726-2fduzqyb 157 20 Reoviridae Reoviridae NNP cord-023726-2fduzqyb 157 21 , , , cord-023726-2fduzqyb 157 22 namely namely RB cord-023726-2fduzqyb 157 23 Reovirus Reovirus NNP cord-023726-2fduzqyb 157 24 , , , cord-023726-2fduzqyb 157 25 Rotavirus Rotavirus NNP cord-023726-2fduzqyb 157 26 , , , cord-023726-2fduzqyb 157 27 and and CC cord-023726-2fduzqyb 157 28 Orbivirus Orbivirus NNP cord-023726-2fduzqyb 157 29 , , , cord-023726-2fduzqyb 157 30 to to IN cord-023726-2fduzqyb 157 31 about about IN cord-023726-2fduzqyb 157 32 25-Å 25-å CD cord-023726-2fduzqyb 157 33 resolution resolution NN cord-023726-2fduzqyb 157 34 . . . cord-023726-2fduzqyb 158 1 Structures structure NNS cord-023726-2fduzqyb 158 2 of of IN cord-023726-2fduzqyb 158 3 a a DT cord-023726-2fduzqyb 158 4 reovirus reovirus NN cord-023726-2fduzqyb 158 5 and and CC cord-023726-2fduzqyb 158 6 of of IN cord-023726-2fduzqyb 158 7 a a DT cord-023726-2fduzqyb 158 8 rotavirus rotavirus NN cord-023726-2fduzqyb 158 9 are be VBP cord-023726-2fduzqyb 158 10 shown show VBN cord-023726-2fduzqyb 158 11 in in IN cord-023726-2fduzqyb 158 12 Fig Fig NNP cord-023726-2fduzqyb 158 13 . . . cord-023726-2fduzqyb 159 1 2 2 LS cord-023726-2fduzqyb 159 2 .5 .5 CD cord-023726-2fduzqyb 159 3 . . . cord-023726-2fduzqyb 160 1 The the DT cord-023726-2fduzqyb 160 2 complete complete JJ cord-023726-2fduzqyb 160 3 structure structure NN cord-023726-2fduzqyb 160 4 of of IN cord-023726-2fduzqyb 160 5 virions virion NNS cord-023726-2fduzqyb 160 6 has have VBZ cord-023726-2fduzqyb 160 7 not not RB cord-023726-2fduzqyb 160 8 been be VBN cord-023726-2fduzqyb 160 9 determined determine VBN cord-023726-2fduzqyb 160 10 because because IN cord-023726-2fduzqyb 160 11 of of IN cord-023726-2fduzqyb 160 12 their -PRON- PRP$ cord-023726-2fduzqyb 160 13 large large JJ cord-023726-2fduzqyb 160 14 size size NN cord-023726-2fduzqyb 160 15 , , , cord-023726-2fduzqyb 160 16 but but CC cord-023726-2fduzqyb 160 17 in in IN cord-023726-2fduzqyb 160 18 a a DT cord-023726-2fduzqyb 160 19 remarkable remarkable JJ cord-023726-2fduzqyb 160 20 feat feat NN cord-023726-2fduzqyb 160 21 the the DT cord-023726-2fduzqyb 160 22 atomic atomic JJ cord-023726-2fduzqyb 160 23 structure structure NN cord-023726-2fduzqyb 160 24 of of IN cord-023726-2fduzqyb 160 25 the the DT cord-023726-2fduzqyb 160 26 core core NN cord-023726-2fduzqyb 160 27 of of IN cord-023726-2fduzqyb 160 28 bluetongue bluetongue NN cord-023726-2fduzqyb 160 29 virus virus NN cord-023726-2fduzqyb 160 30 ( ( -LRB- cord-023726-2fduzqyb 160 31 genus genus NN cord-023726-2fduzqyb 160 32 Orbivirus Orbivirus NNP cord-023726-2fduzqyb 160 33 ) ) -RRB- cord-023726-2fduzqyb 160 34 has have VBZ cord-023726-2fduzqyb 160 35 now now RB cord-023726-2fduzqyb 160 36 been be VBN cord-023726-2fduzqyb 160 37 solved solve VBN cord-023726-2fduzqyb 160 38 . . . cord-023726-2fduzqyb 161 1 This this DT cord-023726-2fduzqyb 161 2 is be VBZ cord-023726-2fduzqyb 161 3 the the DT cord-023726-2fduzqyb 161 4 largest large JJS cord-023726-2fduzqyb 161 5 structure structure NN cord-023726-2fduzqyb 161 6 determined determine VBN cord-023726-2fduzqyb 161 7 to to IN cord-023726-2fduzqyb 161 8 atomic atomic JJ cord-023726-2fduzqyb 161 9 resolution resolution NN cord-023726-2fduzqyb 161 10 to to IN cord-023726-2fduzqyb 161 11 date date NN cord-023726-2fduzqyb 161 12 . . . cord-023726-2fduzqyb 162 1 Solution solution NN cord-023726-2fduzqyb 162 2 of of IN cord-023726-2fduzqyb 162 3 the the DT cord-023726-2fduzqyb 162 4 structure structure NN cord-023726-2fduzqyb 162 5 was be VBD cord-023726-2fduzqyb 162 6 possible possible JJ cord-023726-2fduzqyb 162 7 because because IN cord-023726-2fduzqyb 162 8 the the DT cord-023726-2fduzqyb 162 9 virus virus NN cord-023726-2fduzqyb 162 10 particle particle NN cord-023726-2fduzqyb 162 11 had have VBD cord-023726-2fduzqyb 162 12 been be VBN cord-023726-2fduzqyb 162 13 solved solve VBN cord-023726-2fduzqyb 162 14 to to IN cord-023726-2fduzqyb 162 15 25 25 CD cord-023726-2fduzqyb 162 16 Å å NN cord-023726-2fduzqyb 162 17 by by IN cord-023726-2fduzqyb 162 18 cryoelectron cryoelectron NN cord-023726-2fduzqyb 162 19 microscopy microscopy NNP cord-023726-2fduzqyb 162 20 , , , cord-023726-2fduzqyb 162 21 and and CC cord-023726-2fduzqyb 162 22 the the DT cord-023726-2fduzqyb 162 23 structures structure NNS cord-023726-2fduzqyb 162 24 of of IN cord-023726-2fduzqyb 162 25 a a DT cord-023726-2fduzqyb 162 26 number number NN cord-023726-2fduzqyb 162 27 of of IN cord-023726-2fduzqyb 162 28 virion virion NN cord-023726-2fduzqyb 162 29 proteins protein NNS cord-023726-2fduzqyb 162 30 had have VBD cord-023726-2fduzqyb 162 31 been be VBN cord-023726-2fduzqyb 162 32 solved solve VBN cord-023726-2fduzqyb 162 33 to to IN cord-023726-2fduzqyb 162 34 atomic atomic JJ cord-023726-2fduzqyb 162 35 resolution resolution NN cord-023726-2fduzqyb 162 36 by by IN cord-023726-2fduzqyb 162 37 X x NN cord-023726-2fduzqyb 162 38 - - NN cord-023726-2fduzqyb 162 39 ray ray NN cord-023726-2fduzqyb 162 40 diffraction diffraction NN cord-023726-2fduzqyb 162 41 . . . cord-023726-2fduzqyb 163 1 Fitting fit VBG cord-023726-2fduzqyb 163 2 the the DT cord-023726-2fduzqyb 163 3 atomic atomic JJ cord-023726-2fduzqyb 163 4 structure structure NN cord-023726-2fduzqyb 163 5 of of IN cord-023726-2fduzqyb 163 6 the the DT cord-023726-2fduzqyb 163 7 proteins protein NNS cord-023726-2fduzqyb 163 8 into into IN cord-023726-2fduzqyb 163 9 the the DT cord-023726-2fduzqyb 163 10 25-Å 25-å CD cord-023726-2fduzqyb 163 11 structure structure NN cord-023726-2fduzqyb 163 12 gave give VBD cord-023726-2fduzqyb 163 13 a a DT cord-023726-2fduzqyb 163 14 preliminary preliminary JJ cord-023726-2fduzqyb 163 15 reconstruction reconstruction NN cord-023726-2fduzqyb 163 16 at at IN cord-023726-2fduzqyb 163 17 high high JJ cord-023726-2fduzqyb 163 18 resolution resolution NN cord-023726-2fduzqyb 163 19 , , , cord-023726-2fduzqyb 163 20 which which WDT cord-023726-2fduzqyb 163 21 allowed allow VBD cord-023726-2fduzqyb 163 22 the the DT cord-023726-2fduzqyb 163 23 interpretation interpretation NN cord-023726-2fduzqyb 163 24 of of IN cord-023726-2fduzqyb 163 25 the the DT cord-023726-2fduzqyb 163 26 X x NN cord-023726-2fduzqyb 163 27 - - NN cord-023726-2fduzqyb 163 28 ray ray NN cord-023726-2fduzqyb 163 29 data datum NNS cord-023726-2fduzqyb 163 30 to to IN cord-023726-2fduzqyb 163 31 atomic atomic JJ cord-023726-2fduzqyb 163 32 resolution resolution NN cord-023726-2fduzqyb 163 33 . . . cord-023726-2fduzqyb 164 1 Core core NN cord-023726-2fduzqyb 164 2 particles particle NNS cord-023726-2fduzqyb 164 3 are be VBP cord-023726-2fduzqyb 164 4 formed form VBN cord-023726-2fduzqyb 164 5 following follow VBG cord-023726-2fduzqyb 164 6 infection infection NN cord-023726-2fduzqyb 164 7 , , , cord-023726-2fduzqyb 164 8 when when WRB cord-023726-2fduzqyb 164 9 the the DT cord-023726-2fduzqyb 164 10 outer outer JJ cord-023726-2fduzqyb 164 11 layer layer NN cord-023726-2fduzqyb 164 12 is be VBZ cord-023726-2fduzqyb 164 13 proteolytically proteolytically RB cord-023726-2fduzqyb 164 14 cleaved cleave VBN cord-023726-2fduzqyb 164 15 ( ( -LRB- cord-023726-2fduzqyb 164 16 described describe VBN cord-023726-2fduzqyb 164 17 in in IN cord-023726-2fduzqyb 164 18 more more JJR cord-023726-2fduzqyb 164 19 detail detail NN cord-023726-2fduzqyb 164 20 in in IN cord-023726-2fduzqyb 164 21 Chapter chapter NN cord-023726-2fduzqyb 164 22 5 5 CD cord-023726-2fduzqyb 164 23 ) ) -RRB- cord-023726-2fduzqyb 164 24 . . . cord-023726-2fduzqyb 165 1 The the DT cord-023726-2fduzqyb 165 2 structure structure NN cord-023726-2fduzqyb 165 3 of of IN cord-023726-2fduzqyb 165 4 the the DT cord-023726-2fduzqyb 165 5 inner inner JJ cord-023726-2fduzqyb 165 6 surface surface NN cord-023726-2fduzqyb 165 7 of of IN cord-023726-2fduzqyb 165 8 the the DT cord-023726-2fduzqyb 165 9 bluetongue bluetongue NN cord-023726-2fduzqyb 165 10 virus virus NN cord-023726-2fduzqyb 165 11 core core NN cord-023726-2fduzqyb 165 12 is be VBZ cord-023726-2fduzqyb 165 13 shown show VBN cord-023726-2fduzqyb 165 14 in in IN cord-023726-2fduzqyb 165 15 Fig Fig NNP cord-023726-2fduzqyb 165 16 . . . cord-023726-2fduzqyb 166 1 2 2 LS cord-023726-2fduzqyb 166 2 .11A .11A . cord-023726-2fduzqyb 167 1 and and CC cord-023726-2fduzqyb 167 2 of of IN cord-023726-2fduzqyb 167 3 the the DT cord-023726-2fduzqyb 167 4 outer outer JJ cord-023726-2fduzqyb 167 5 surface surface NN cord-023726-2fduzqyb 167 6 in in IN cord-023726-2fduzqyb 167 7 Fig Fig NNP cord-023726-2fduzqyb 167 8 . . . cord-023726-2fduzqyb 168 1 2 2 LS cord-023726-2fduzqyb 168 2 .11B. .11B. . cord-023726-2fduzqyb 169 1 The the DT cord-023726-2fduzqyb 169 2 outer outer JJ cord-023726-2fduzqyb 169 3 surface surface NN cord-023726-2fduzqyb 169 4 is be VBZ cord-023726-2fduzqyb 169 5 formed form VBN cord-023726-2fduzqyb 169 6 by by IN cord-023726-2fduzqyb 169 7 780 780 CD cord-023726-2fduzqyb 169 8 copies copy NNS cord-023726-2fduzqyb 169 9 of of IN cord-023726-2fduzqyb 169 10 a a DT cord-023726-2fduzqyb 169 11 single single JJ cord-023726-2fduzqyb 169 12 protein protein NN cord-023726-2fduzqyb 169 13 , , , cord-023726-2fduzqyb 169 14 called call VBD cord-023726-2fduzqyb 169 15 VP7 VP7 NNP cord-023726-2fduzqyb 169 16 , , , cord-023726-2fduzqyb 169 17 in in IN cord-023726-2fduzqyb 169 18 a a DT cord-023726-2fduzqyb 169 19 regular regular JJ cord-023726-2fduzqyb 169 20 T=13 t=13 JJ cord-023726-2fduzqyb 169 21 icosahedral icosahedral JJ cord-023726-2fduzqyb 169 22 lattice lattice NN cord-023726-2fduzqyb 169 23 . . . cord-023726-2fduzqyb 170 1 The the DT cord-023726-2fduzqyb 170 2 inner inner JJ cord-023726-2fduzqyb 170 3 surface surface NN cord-023726-2fduzqyb 170 4 is be VBZ cord-023726-2fduzqyb 170 5 surprising surprising JJ cord-023726-2fduzqyb 170 6 , , , cord-023726-2fduzqyb 170 7 however however RB cord-023726-2fduzqyb 170 8 . . . cord-023726-2fduzqyb 171 1 It -PRON- PRP cord-023726-2fduzqyb 171 2 is be VBZ cord-023726-2fduzqyb 171 3 formed form VBN cord-023726-2fduzqyb 171 4 by by IN cord-023726-2fduzqyb 171 5 120 120 CD cord-023726-2fduzqyb 171 6 copies copy NNS cord-023726-2fduzqyb 171 7 of of IN cord-023726-2fduzqyb 171 8 a a DT cord-023726-2fduzqyb 171 9 single single JJ cord-023726-2fduzqyb 171 10 protein protein NN cord-023726-2fduzqyb 171 11 , , , cord-023726-2fduzqyb 171 12 called call VBN cord-023726-2fduzqyb 171 13 VP3 VP3 NNP cord-023726-2fduzqyb 171 14 . . . cord-023726-2fduzqyb 172 1 These these DT cord-023726-2fduzqyb 172 2 120 120 CD cord-023726-2fduzqyb 172 3 copies copy NNS cord-023726-2fduzqyb 172 4 have have VBP cord-023726-2fduzqyb 172 5 been be VBN cord-023726-2fduzqyb 172 6 described describe VBN cord-023726-2fduzqyb 172 7 as as IN cord-023726-2fduzqyb 172 8 forming form VBG cord-023726-2fduzqyb 172 9 a a DT cord-023726-2fduzqyb 172 10 T=2 T=2 NNP cord-023726-2fduzqyb 172 11 Five five CD cord-023726-2fduzqyb 172 12 - - JJ cord-023726-2fduzqyb 172 13 fold fold JJ cord-023726-2fduzqyb 172 14 Axis Axis NNP cord-023726-2fduzqyb 172 15 lattice lattice NN cord-023726-2fduzqyb 172 16 . . . cord-023726-2fduzqyb 173 1 Because because IN cord-023726-2fduzqyb 173 2 T=2 T=2 NNP cord-023726-2fduzqyb 173 3 is be VBZ cord-023726-2fduzqyb 173 4 not not RB cord-023726-2fduzqyb 173 5 a a DT cord-023726-2fduzqyb 173 6 permitted permit VBN cord-023726-2fduzqyb 173 7 triangulation triangulation NN cord-023726-2fduzqyb 173 8 number number NN cord-023726-2fduzqyb 173 9 , , , cord-023726-2fduzqyb 173 10 these these DT cord-023726-2fduzqyb 173 11 120 120 CD cord-023726-2fduzqyb 173 12 copies copy NNS cord-023726-2fduzqyb 173 13 , , , cord-023726-2fduzqyb 173 14 strictly strictly RB cord-023726-2fduzqyb 173 15 speaking speak VBG cord-023726-2fduzqyb 173 16 , , , cord-023726-2fduzqyb 173 17 form form VB cord-023726-2fduzqyb 173 18 a a DT cord-023726-2fduzqyb 173 19 T=1 T=1 NNP cord-023726-2fduzqyb 173 20 lattice lattice NN cord-023726-2fduzqyb 173 21 in in IN cord-023726-2fduzqyb 173 22 which which WDT cord-023726-2fduzqyb 173 23 each each DT cord-023726-2fduzqyb 173 24 unit unit NN cord-023726-2fduzqyb 173 25 of of IN cord-023726-2fduzqyb 173 26 the the DT cord-023726-2fduzqyb 173 27 lattice lattice NN cord-023726-2fduzqyb 173 28 is be VBZ cord-023726-2fduzqyb 173 29 composed compose VBN cord-023726-2fduzqyb 173 30 of of IN cord-023726-2fduzqyb 173 31 two two CD cord-023726-2fduzqyb 173 32 copies copy NNS cord-023726-2fduzqyb 173 33 of of IN cord-023726-2fduzqyb 173 34 VP3 VP3 NNP cord-023726-2fduzqyb 173 35 . . . cord-023726-2fduzqyb 174 1 However however RB cord-023726-2fduzqyb 174 2 , , , cord-023726-2fduzqyb 174 3 the the DT cord-023726-2fduzqyb 174 4 interactions interaction NNS cord-023726-2fduzqyb 174 5 are be VBP cord-023726-2fduzqyb 174 6 not not RB cord-023726-2fduzqyb 174 7 symmetrical symmetrical JJ cord-023726-2fduzqyb 174 8 , , , cord-023726-2fduzqyb 174 9 leading lead VBG cord-023726-2fduzqyb 174 10 to to IN cord-023726-2fduzqyb 174 11 the the DT cord-023726-2fduzqyb 174 12 suggested suggest VBN cord-023726-2fduzqyb 174 13 terminology terminology NN cord-023726-2fduzqyb 174 14 of of IN cord-023726-2fduzqyb 174 15 T=2 T=2 NNP cord-023726-2fduzqyb 174 16 . . . cord-023726-2fduzqyb 175 1 It -PRON- PRP cord-023726-2fduzqyb 175 2 has have VBZ cord-023726-2fduzqyb 175 3 been be VBN cord-023726-2fduzqyb 175 4 suggested suggest VBN cord-023726-2fduzqyb 175 5 that that IN cord-023726-2fduzqyb 175 6 the the DT cord-023726-2fduzqyb 175 7 inner inner JJ cord-023726-2fduzqyb 175 8 core core NN cord-023726-2fduzqyb 175 9 furnishes furnish VBZ cord-023726-2fduzqyb 175 10 a a DT cord-023726-2fduzqyb 175 11 template template NN cord-023726-2fduzqyb 175 12 for for IN cord-023726-2fduzqyb 175 13 the the DT cord-023726-2fduzqyb 175 14 assembly assembly NN cord-023726-2fduzqyb 175 15 of of IN cord-023726-2fduzqyb 175 16 the the DT cord-023726-2fduzqyb 175 17 T=13 t=13 JJ cord-023726-2fduzqyb 175 18 outer outer JJ cord-023726-2fduzqyb 175 19 surface surface NN cord-023726-2fduzqyb 175 20 . . . cord-023726-2fduzqyb 176 1 The the DT cord-023726-2fduzqyb 176 2 reasoning reasoning NN cord-023726-2fduzqyb 176 3 is be VBZ cord-023726-2fduzqyb 176 4 that that IN cord-023726-2fduzqyb 176 5 a a DT cord-023726-2fduzqyb 176 6 T=13 t=13 JJ cord-023726-2fduzqyb 176 7 structure structure NN cord-023726-2fduzqyb 176 8 may may MD cord-023726-2fduzqyb 176 9 have have VB cord-023726-2fduzqyb 176 10 difficulty difficulty NN cord-023726-2fduzqyb 176 11 in in IN cord-023726-2fduzqyb 176 12 forming form VBG cord-023726-2fduzqyb 176 13 , , , cord-023726-2fduzqyb 176 14 whereas whereas IN cord-023726-2fduzqyb 176 15 the the DT cord-023726-2fduzqyb 176 16 T=2 T=2 NNP cord-023726-2fduzqyb 176 17 ( ( -LRB- cord-023726-2fduzqyb 176 18 or or CC cord-023726-2fduzqyb 176 19 T=1 T=1 NNP cord-023726-2fduzqyb 176 20 ) ) -RRB- cord-023726-2fduzqyb 176 21 structure structure NN cord-023726-2fduzqyb 176 22 could could MD cord-023726-2fduzqyb 176 23 form form VB cord-023726-2fduzqyb 176 24 readily readily RB cord-023726-2fduzqyb 176 25 . . . cord-023726-2fduzqyb 177 1 In in IN cord-023726-2fduzqyb 177 2 this this DT cord-023726-2fduzqyb 177 3 model model NN cord-023726-2fduzqyb 177 4 , , , cord-023726-2fduzqyb 177 5 the the DT cord-023726-2fduzqyb 177 6 threefold threefold JJ cord-023726-2fduzqyb 177 7 symmetry symmetry NN cord-023726-2fduzqyb 177 8 axis axis NN cord-023726-2fduzqyb 177 9 of of IN cord-023726-2fduzqyb 177 10 the the DT cord-023726-2fduzqyb 177 11 inner inner JJ cord-023726-2fduzqyb 177 12 surface surface NN cord-023726-2fduzqyb 177 13 could could MD cord-023726-2fduzqyb 177 14 serve serve VB cord-023726-2fduzqyb 177 15 to to TO cord-023726-2fduzqyb 177 16 nucleate nucleate VB cord-023726-2fduzqyb 177 17 VP7 vp7 NN cord-023726-2fduzqyb 177 18 trimers trimer NNS cord-023726-2fduzqyb 177 19 and and CC cord-023726-2fduzqyb 177 20 organize organize VB cord-023726-2fduzqyb 177 21 the the DT cord-023726-2fduzqyb 177 22 T=13 t=13 JJ cord-023726-2fduzqyb 177 23 structure structure NN cord-023726-2fduzqyb 177 24 . . . cord-023726-2fduzqyb 178 1 Cryoelectron Cryoelectron NNP cord-023726-2fduzqyb 178 2 microscopy microscopy NN cord-023726-2fduzqyb 178 3 has have VBZ cord-023726-2fduzqyb 178 4 also also RB cord-023726-2fduzqyb 178 5 been be VBN cord-023726-2fduzqyb 178 6 applied apply VBN cord-023726-2fduzqyb 178 7 to to IN cord-023726-2fduzqyb 178 8 adenoviruses adenovirus NNS cord-023726-2fduzqyb 178 9 , , , cord-023726-2fduzqyb 178 10 which which WDT cord-023726-2fduzqyb 178 11 have have VBP cord-023726-2fduzqyb 178 12 a a DT cord-023726-2fduzqyb 178 13 triangulation triangulation NN cord-023726-2fduzqyb 178 14 number number NN cord-023726-2fduzqyb 178 15 of of IN cord-023726-2fduzqyb 178 16 25 25 CD cord-023726-2fduzqyb 178 17 or or CC cord-023726-2fduzqyb 178 18 pseudo-25 pseudo-25 CD cord-023726-2fduzqyb 178 19 . . . cord-023726-2fduzqyb 179 1 Various various JJ cord-023726-2fduzqyb 179 2 interpretations interpretation NNS cord-023726-2fduzqyb 179 3 of of IN cord-023726-2fduzqyb 179 4 the the DT cord-023726-2fduzqyb 179 5 structure structure NN cord-023726-2fduzqyb 179 6 of of IN cord-023726-2fduzqyb 179 7 adenoviruses adenovirus NNS cord-023726-2fduzqyb 179 8 , , , cord-023726-2fduzqyb 179 9 both both DT cord-023726-2fduzqyb 179 10 schematic schematic VBP cord-023726-2fduzqyb 179 11 and and CC cord-023726-2fduzqyb 179 12 as as IN cord-023726-2fduzqyb 179 13 determined determine VBN cord-023726-2fduzqyb 179 14 by by IN cord-023726-2fduzqyb 179 15 microscopy microscopy NNS cord-023726-2fduzqyb 179 16 or or CC cord-023726-2fduzqyb 179 17 crystallography crystallography NN cord-023726-2fduzqyb 179 18 , , , cord-023726-2fduzqyb 179 19 are be VBP cord-023726-2fduzqyb 179 20 shown show VBN cord-023726-2fduzqyb 179 21 in in IN cord-023726-2fduzqyb 179 22 Fig Fig NNP cord-023726-2fduzqyb 179 23 . . . cord-023726-2fduzqyb 180 1 2 2 LS cord-023726-2fduzqyb 180 2 .12 .12 NFP cord-023726-2fduzqyb 180 3 . . . cord-023726-2fduzqyb 181 1 Three three CD cord-023726-2fduzqyb 181 2 copies copy NNS cord-023726-2fduzqyb 181 3 of of IN cord-023726-2fduzqyb 181 4 a a DT cord-023726-2fduzqyb 181 5 protein protein NN cord-023726-2fduzqyb 181 6 called call VBN cord-023726-2fduzqyb 181 7 the the DT cord-023726-2fduzqyb 181 8 hexon hexon NNP cord-023726-2fduzqyb 181 9 protein protein NNP cord-023726-2fduzqyb 181 10 associate associate NNP cord-023726-2fduzqyb 181 11 to to TO cord-023726-2fduzqyb 181 12 form form VB cord-023726-2fduzqyb 181 13 a a DT cord-023726-2fduzqyb 181 14 structure structure NN cord-023726-2fduzqyb 181 15 called call VBN cord-023726-2fduzqyb 181 16 a a DT cord-023726-2fduzqyb 181 17 hexon hexon NN cord-023726-2fduzqyb 181 18 ( ( -LRB- cord-023726-2fduzqyb 181 19 Fig fig NN cord-023726-2fduzqyb 181 20 . . . cord-023726-2fduzqyb 181 21 2.12C 2.12c CD cord-023726-2fduzqyb 181 22 ) ) -RRB- cord-023726-2fduzqyb 181 23 . . . cord-023726-2fduzqyb 182 1 The the DT cord-023726-2fduzqyb 182 2 hexon hexon NN cord-023726-2fduzqyb 182 3 is be VBZ cord-023726-2fduzqyb 182 4 the the DT cord-023726-2fduzqyb 182 5 basic basic JJ cord-023726-2fduzqyb 182 6 building building NN cord-023726-2fduzqyb 182 7 block block NN cord-023726-2fduzqyb 182 8 of of IN cord-023726-2fduzqyb 182 9 adenoviruses adenovirus NNS cord-023726-2fduzqyb 182 10 . . . cord-023726-2fduzqyb 183 1 Five five CD cord-023726-2fduzqyb 183 2 hexons hexon NNS cord-023726-2fduzqyb 183 3 , , , cord-023726-2fduzqyb 183 4 called call VBN cord-023726-2fduzqyb 183 5 peripentonal peripentonal NNP cord-023726-2fduzqyb 183 6 hexons hexons NNPS cord-023726-2fduzqyb 183 7 , , , cord-023726-2fduzqyb 183 8 surround surround VB cord-023726-2fduzqyb 183 9 each each DT cord-023726-2fduzqyb 183 10 of of IN cord-023726-2fduzqyb 183 11 the the DT cord-023726-2fduzqyb 183 12 12 12 CD cord-023726-2fduzqyb 183 13 vertices vertex NNS cord-023726-2fduzqyb 183 14 of of IN cord-023726-2fduzqyb 183 15 the the DT cord-023726-2fduzqyb 183 16 icosahedron icosahedron NN cord-023726-2fduzqyb 183 17 ( ( -LRB- cord-023726-2fduzqyb 183 18 which which WDT cord-023726-2fduzqyb 183 19 , , , cord-023726-2fduzqyb 183 20 as as IN cord-023726-2fduzqyb 183 21 has have VBZ cord-023726-2fduzqyb 183 22 been be VBN cord-023726-2fduzqyb 183 23 stated state VBN cord-023726-2fduzqyb 183 24 , , , cord-023726-2fduzqyb 183 25 have have VBP cord-023726-2fduzqyb 183 26 fivefold fivefold JJ cord-023726-2fduzqyb 183 27 rotational rotational JJ cord-023726-2fduzqyb 183 28 symmetry symmetry NN cord-023726-2fduzqyb 183 29 ) ) -RRB- cord-023726-2fduzqyb 183 30 . . . cord-023726-2fduzqyb 184 1 Between between IN cord-023726-2fduzqyb 184 2 the the DT cord-023726-2fduzqyb 184 3 groups group NNS cord-023726-2fduzqyb 184 4 of of IN cord-023726-2fduzqyb 184 5 peripentonal peripentonal NNP cord-023726-2fduzqyb 184 6 hexons hexons NNPS cord-023726-2fduzqyb 184 7 are be VBP cord-023726-2fduzqyb 184 8 found find VBN cord-023726-2fduzqyb 184 9 groups group NNS cord-023726-2fduzqyb 184 10 of of IN cord-023726-2fduzqyb 184 11 9 9 CD cord-023726-2fduzqyb 184 12 hexons hexon NNS cord-023726-2fduzqyb 184 13 , , , cord-023726-2fduzqyb 184 14 which which WDT cord-023726-2fduzqyb 184 15 are be VBP cord-023726-2fduzqyb 184 16 sixfold sixfold RB cord-023726-2fduzqyb 184 17 coordinated coordinate VBN cord-023726-2fduzqyb 184 18 . . . cord-023726-2fduzqyb 185 1 Each each DT cord-023726-2fduzqyb 185 2 group group NN cord-023726-2fduzqyb 185 3 of of IN cord-023726-2fduzqyb 185 4 9 9 CD cord-023726-2fduzqyb 185 5 hexons hexon NNS cord-023726-2fduzqyb 185 6 forms form VBZ cord-023726-2fduzqyb 185 7 the the DT cord-023726-2fduzqyb 185 8 surface surface NN cord-023726-2fduzqyb 185 9 of of IN cord-023726-2fduzqyb 185 10 one one CD cord-023726-2fduzqyb 185 11 of of IN cord-023726-2fduzqyb 185 12 the the DT cord-023726-2fduzqyb 185 13 triangular triangular JJ cord-023726-2fduzqyb 185 14 faces face NNS cord-023726-2fduzqyb 185 15 . . . cord-023726-2fduzqyb 186 1 Thus thus RB cord-023726-2fduzqyb 186 2 , , , cord-023726-2fduzqyb 186 3 there there EX cord-023726-2fduzqyb 186 4 are be VBP cord-023726-2fduzqyb 186 5 60 60 CD cord-023726-2fduzqyb 186 6 peripentonal peripentonal JJ cord-023726-2fduzqyb 186 7 hexons hexon NNS cord-023726-2fduzqyb 186 8 and and CC cord-023726-2fduzqyb 186 9 180 180 CD cord-023726-2fduzqyb 186 10 hexons hexon NNS cord-023726-2fduzqyb 186 11 in in IN cord-023726-2fduzqyb 186 12 groups group NNS cord-023726-2fduzqyb 186 13 of of IN cord-023726-2fduzqyb 186 14 nine nine CD cord-023726-2fduzqyb 186 15 . . . cord-023726-2fduzqyb 187 1 The the DT cord-023726-2fduzqyb 187 2 structure structure NN cord-023726-2fduzqyb 187 3 of of IN cord-023726-2fduzqyb 187 4 the the DT cord-023726-2fduzqyb 187 5 hexon hexon NNP cord-023726-2fduzqyb 187 6 trimer trimer NNP cord-023726-2fduzqyb 187 7 has have VBZ cord-023726-2fduzqyb 187 8 been be VBN cord-023726-2fduzqyb 187 9 solved solve VBN cord-023726-2fduzqyb 187 10 to to IN cord-023726-2fduzqyb 187 11 atomic atomic JJ cord-023726-2fduzqyb 187 12 resolution resolution NN cord-023726-2fduzqyb 187 13 by by IN cord-023726-2fduzqyb 187 14 X x NN cord-023726-2fduzqyb 187 15 - - NN cord-023726-2fduzqyb 187 16 ray ray NN cord-023726-2fduzqyb 187 17 crystallography crystallography NN cord-023726-2fduzqyb 187 18 ( ( -LRB- cord-023726-2fduzqyb 187 19 Fig Fig NNP cord-023726-2fduzqyb 187 20 . . . cord-023726-2fduzqyb 187 21 2.12C 2.12c CD cord-023726-2fduzqyb 187 22 ) ) -RRB- cord-023726-2fduzqyb 187 23 . . . cord-023726-2fduzqyb 188 1 The the DT cord-023726-2fduzqyb 188 2 hexon hexon NN cord-023726-2fduzqyb 188 3 protein protein NN cord-023726-2fduzqyb 188 4 has have VBZ cord-023726-2fduzqyb 188 5 two two CD cord-023726-2fduzqyb 188 6 eight eight CD cord-023726-2fduzqyb 188 7 - - HYPH cord-023726-2fduzqyb 188 8 strand strand NN cord-023726-2fduzqyb 188 9 β β NN cord-023726-2fduzqyb 188 10 sandwiches sandwich NNS cord-023726-2fduzqyb 188 11 to to TO cord-023726-2fduzqyb 188 12 give give VB cord-023726-2fduzqyb 188 13 the the DT cord-023726-2fduzqyb 188 14 trimer trimer NN cord-023726-2fduzqyb 188 15 an an DT cord-023726-2fduzqyb 188 16 approximately approximately RB cord-023726-2fduzqyb 188 17 sixfold sixfold JJ cord-023726-2fduzqyb 188 18 symmetry symmetry NN cord-023726-2fduzqyb 188 19 ( ( -LRB- cord-023726-2fduzqyb 188 20 and and CC cord-023726-2fduzqyb 188 21 each each DT cord-023726-2fduzqyb 188 22 hexon hexon NNP cord-023726-2fduzqyb 188 23 protein protein NN cord-023726-2fduzqyb 188 24 fills fill VBZ cord-023726-2fduzqyb 188 25 the the DT cord-023726-2fduzqyb 188 26 role role NN cord-023726-2fduzqyb 188 27 of of IN cord-023726-2fduzqyb 188 28 two two CD cord-023726-2fduzqyb 188 29 symmetry symmetry NN cord-023726-2fduzqyb 188 30 units unit NNS cord-023726-2fduzqyb 188 31 ) ) -RRB- cord-023726-2fduzqyb 188 32 . . . cord-023726-2fduzqyb 189 1 There there EX cord-023726-2fduzqyb 189 2 are be VBP cord-023726-2fduzqyb 189 3 long long JJ cord-023726-2fduzqyb 189 4 loops loop NNS cord-023726-2fduzqyb 189 5 that that WDT cord-023726-2fduzqyb 189 6 intertwine intertwine VBP cord-023726-2fduzqyb 189 7 to to TO cord-023726-2fduzqyb 189 8 form form VB cord-023726-2fduzqyb 189 9 a a DT cord-023726-2fduzqyb 189 10 triangular triangular JJ cord-023726-2fduzqyb 189 11 top top NN cord-023726-2fduzqyb 189 12 . . . cord-023726-2fduzqyb 190 1 These these DT cord-023726-2fduzqyb 190 2 structures structure NNS cord-023726-2fduzqyb 190 3 can can MD cord-023726-2fduzqyb 190 4 be be VB cord-023726-2fduzqyb 190 5 fitted fit VBN cord-023726-2fduzqyb 190 6 uniquely uniquely RB cord-023726-2fduzqyb 190 7 into into IN cord-023726-2fduzqyb 190 8 the the DT cord-023726-2fduzqyb 190 9 envelope envelope NN cord-023726-2fduzqyb 190 10 of of IN cord-023726-2fduzqyb 190 11 density density NN cord-023726-2fduzqyb 190 12 determined determine VBN cord-023726-2fduzqyb 190 13 by by IN cord-023726-2fduzqyb 190 14 cryoelectron cryoelectron NNP cord-023726-2fduzqyb 190 15 microscopy microscopy NNP cord-023726-2fduzqyb 190 16 , , , cord-023726-2fduzqyb 190 17 which which WDT cord-023726-2fduzqyb 190 18 produces produce VBZ cord-023726-2fduzqyb 190 19 a a DT cord-023726-2fduzqyb 190 20 structure structure NN cord-023726-2fduzqyb 190 21 refined refine VBN cord-023726-2fduzqyb 190 22 to to IN cord-023726-2fduzqyb 190 23 atomic atomic JJ cord-023726-2fduzqyb 190 24 resolution resolution NN cord-023726-2fduzqyb 190 25 for for IN cord-023726-2fduzqyb 190 26 most most JJS cord-023726-2fduzqyb 190 27 of of IN cord-023726-2fduzqyb 190 28 the the DT cord-023726-2fduzqyb 190 29 capsid capsid NN cord-023726-2fduzqyb 190 30 . . . cord-023726-2fduzqyb 191 1 The the DT cord-023726-2fduzqyb 191 2 minor minor JJ cord-023726-2fduzqyb 191 3 proteins protein NNS cord-023726-2fduzqyb 191 4 can can MD cord-023726-2fduzqyb 191 5 be be VB cord-023726-2fduzqyb 191 6 fitted fit VBN cord-023726-2fduzqyb 191 7 into into IN cord-023726-2fduzqyb 191 8 this this DT cord-023726-2fduzqyb 191 9 structure structure NN cord-023726-2fduzqyb 191 10 . . . cord-023726-2fduzqyb 192 1 From from IN cord-023726-2fduzqyb 192 2 the the DT cord-023726-2fduzqyb 192 3 12 12 CD cord-023726-2fduzqyb 192 4 vertices vertex NNS cord-023726-2fduzqyb 192 5 of of IN cord-023726-2fduzqyb 192 6 the the DT cord-023726-2fduzqyb 192 7 icosahedron icosahedron NN cord-023726-2fduzqyb 192 8 project project NN cord-023726-2fduzqyb 192 9 long long JJ cord-023726-2fduzqyb 192 10 fibers fiber NNS cord-023726-2fduzqyb 192 11 that that WDT cord-023726-2fduzqyb 192 12 are be VBP cord-023726-2fduzqyb 192 13 anchored anchor VBN cord-023726-2fduzqyb 192 14 in in IN cord-023726-2fduzqyb 192 15 the the DT cord-023726-2fduzqyb 192 16 surface surface NN cord-023726-2fduzqyb 192 17 by by IN cord-023726-2fduzqyb 192 18 a a DT cord-023726-2fduzqyb 192 19 unit unit NN cord-023726-2fduzqyb 192 20 called call VBN cord-023726-2fduzqyb 192 21 the the DT cord-023726-2fduzqyb 192 22 penton penton NNP cord-023726-2fduzqyb 192 23 base base NN cord-023726-2fduzqyb 192 24 . . . cord-023726-2fduzqyb 193 1 Each each DT cord-023726-2fduzqyb 193 2 fiber fiber NN cord-023726-2fduzqyb 193 3 terminates terminate VBZ cord-023726-2fduzqyb 193 4 in in IN cord-023726-2fduzqyb 193 5 a a DT cord-023726-2fduzqyb 193 6 spherical spherical JJ cord-023726-2fduzqyb 193 7 extension extension NN cord-023726-2fduzqyb 193 8 that that WDT cord-023726-2fduzqyb 193 9 forms form VBZ cord-023726-2fduzqyb 193 10 an an DT cord-023726-2fduzqyb 193 11 organ organ NN cord-023726-2fduzqyb 193 12 of of IN cord-023726-2fduzqyb 193 13 attachment attachment NN cord-023726-2fduzqyb 193 14 to to IN cord-023726-2fduzqyb 193 15 a a DT cord-023726-2fduzqyb 193 16 host host NN cord-023726-2fduzqyb 193 17 cell cell NN cord-023726-2fduzqyb 193 18 ( ( -LRB- cord-023726-2fduzqyb 193 19 Fig Fig NNP cord-023726-2fduzqyb 193 20 . . . cord-023726-2fduzqyb 193 21 2.12A 2.12a CD cord-023726-2fduzqyb 193 22 ) ) -RRB- cord-023726-2fduzqyb 193 23 . . . cord-023726-2fduzqyb 194 1 The the DT cord-023726-2fduzqyb 194 2 length length NN cord-023726-2fduzqyb 194 3 of of IN cord-023726-2fduzqyb 194 4 the the DT cord-023726-2fduzqyb 194 5 fiber fiber NN cord-023726-2fduzqyb 194 6 differs differ VBZ cord-023726-2fduzqyb 194 7 in in IN cord-023726-2fduzqyb 194 8 the the DT cord-023726-2fduzqyb 194 9 different different JJ cord-023726-2fduzqyb 194 10 adenoviruses adenovirus NNS cord-023726-2fduzqyb 194 11 . . . cord-023726-2fduzqyb 195 1 In in IN cord-023726-2fduzqyb 195 2 addition addition NN cord-023726-2fduzqyb 195 3 to to IN cord-023726-2fduzqyb 195 4 the the DT cord-023726-2fduzqyb 195 5 nonenveloped nonenveloped JJ cord-023726-2fduzqyb 195 6 viruses virus NNS cord-023726-2fduzqyb 195 7 that that WDT cord-023726-2fduzqyb 195 8 possess possess VBP cord-023726-2fduzqyb 195 9 relatively relatively RB cord-023726-2fduzqyb 195 10 straightforward straightforward JJ cord-023726-2fduzqyb 195 11 icosahedral icosahedral JJ cord-023726-2fduzqyb 195 12 symmetry symmetry NN cord-023726-2fduzqyb 195 13 or or CC cord-023726-2fduzqyb 195 14 helical helical JJ cord-023726-2fduzqyb 195 15 symmetry symmetry NN cord-023726-2fduzqyb 195 16 , , , cord-023726-2fduzqyb 195 17 many many JJ cord-023726-2fduzqyb 195 18 viruses virus NNS cord-023726-2fduzqyb 195 19 possess possess VBP cord-023726-2fduzqyb 195 20 more more RBR cord-023726-2fduzqyb 195 21 complicated complicated JJ cord-023726-2fduzqyb 195 22 symmetries symmetry NNS cord-023726-2fduzqyb 195 23 made make VBN cord-023726-2fduzqyb 195 24 possible possible JJ cord-023726-2fduzqyb 195 25 by by IN cord-023726-2fduzqyb 195 26 the the DT cord-023726-2fduzqyb 195 27 utilization utilization NN cord-023726-2fduzqyb 195 28 of of IN cord-023726-2fduzqyb 195 29 a a DT cord-023726-2fduzqyb 195 30 large large JJ cord-023726-2fduzqyb 195 31 number number NN cord-023726-2fduzqyb 195 32 of of IN cord-023726-2fduzqyb 195 33 structural structural JJ cord-023726-2fduzqyb 195 34 proteins protein NNS cord-023726-2fduzqyb 195 35 to to TO cord-023726-2fduzqyb 195 36 form form VB cord-023726-2fduzqyb 195 37 the the DT cord-023726-2fduzqyb 195 38 virion virion NN cord-023726-2fduzqyb 195 39 . . . cord-023726-2fduzqyb 196 1 The the DT cord-023726-2fduzqyb 196 2 tailed tailed JJ cord-023726-2fduzqyb 196 3 bacteriophages bacteriophage NNS cord-023726-2fduzqyb 196 4 are be VBP cord-023726-2fduzqyb 196 5 prominent prominent JJ cord-023726-2fduzqyb 196 6 examples example NNS cord-023726-2fduzqyb 196 7 of of IN cord-023726-2fduzqyb 196 8 this this DT cord-023726-2fduzqyb 196 9 ( ( -LRB- cord-023726-2fduzqyb 196 10 Fig Fig NNP cord-023726-2fduzqyb 196 11 . . . cord-023726-2fduzqyb 196 12 2.13 2.13 CD cord-023726-2fduzqyb 196 13 ) ) -RRB- cord-023726-2fduzqyb 196 14 . . . cord-023726-2fduzqyb 197 1 Some some DT cord-023726-2fduzqyb 197 2 of of IN cord-023726-2fduzqyb 197 3 the the DT cord-023726-2fduzqyb 197 4 tailed tailed JJ cord-023726-2fduzqyb 197 5 bacteriophages bacteriophage NNS cord-023726-2fduzqyb 197 6 possess possess VBP cord-023726-2fduzqyb 197 7 a a DT cord-023726-2fduzqyb 197 8 head head NN cord-023726-2fduzqyb 197 9 that that WDT cord-023726-2fduzqyb 197 10 is be VBZ cord-023726-2fduzqyb 197 11 a a DT cord-023726-2fduzqyb 197 12 regular regular JJ cord-023726-2fduzqyb 197 13 icosahedron icosahedron NN cord-023726-2fduzqyb 197 14 ( ( -LRB- cord-023726-2fduzqyb 197 15 or or CC cord-023726-2fduzqyb 197 16 , , , cord-023726-2fduzqyb 197 17 in in IN cord-023726-2fduzqyb 197 18 at at RB cord-023726-2fduzqyb 197 19 least least RBS cord-023726-2fduzqyb 197 20 one one CD cord-023726-2fduzqyb 197 21 case case NN cord-023726-2fduzqyb 197 22 , , , cord-023726-2fduzqyb 197 23 an an DT cord-023726-2fduzqyb 197 24 octahedron octahedron NN cord-023726-2fduzqyb 197 25 ) ) -RRB- cord-023726-2fduzqyb 197 26 connected connect VBN cord-023726-2fduzqyb 197 27 to to IN cord-023726-2fduzqyb 197 28 a a DT cord-023726-2fduzqyb 197 29 tail tail NN cord-023726-2fduzqyb 197 30 that that WDT cord-023726-2fduzqyb 197 31 possesses possess VBZ cord-023726-2fduzqyb 197 32 helical helical JJ cord-023726-2fduzqyb 197 33 symmetry symmetry NN cord-023726-2fduzqyb 197 34 . . . cord-023726-2fduzqyb 198 1 Other other JJ cord-023726-2fduzqyb 198 2 appendages appendage NNS cord-023726-2fduzqyb 198 3 , , , cord-023726-2fduzqyb 198 4 such such JJ cord-023726-2fduzqyb 198 5 as as IN cord-023726-2fduzqyb 198 6 baseplates baseplate NNS cord-023726-2fduzqyb 198 7 , , , cord-023726-2fduzqyb 198 8 collars collar NNS cord-023726-2fduzqyb 198 9 , , , cord-023726-2fduzqyb 198 10 and and CC cord-023726-2fduzqyb 198 11 tail tail NN cord-023726-2fduzqyb 198 12 fibers fiber NNS cord-023726-2fduzqyb 198 13 , , , cord-023726-2fduzqyb 198 14 may may MD cord-023726-2fduzqyb 198 15 be be VB cord-023726-2fduzqyb 198 16 connected connect VBN cord-023726-2fduzqyb 198 17 to to IN cord-023726-2fduzqyb 198 18 the the DT cord-023726-2fduzqyb 198 19 tail tail NN cord-023726-2fduzqyb 198 20 . . . cord-023726-2fduzqyb 199 1 Other other JJ cord-023726-2fduzqyb 199 2 tailed tailed JJ cord-023726-2fduzqyb 199 3 bacteriophages bacteriophage NNS cord-023726-2fduzqyb 199 4 have have VBP cord-023726-2fduzqyb 199 5 heads head NNS cord-023726-2fduzqyb 199 6 that that WDT cord-023726-2fduzqyb 199 7 are be VBP cord-023726-2fduzqyb 199 8 assembled assemble VBN cord-023726-2fduzqyb 199 9 using use VBG cord-023726-2fduzqyb 199 10 more more RBR cord-023726-2fduzqyb 199 11 complicated complicated JJ cord-023726-2fduzqyb 199 12 patterns pattern NNS cord-023726-2fduzqyb 199 13 . . . cord-023726-2fduzqyb 200 1 For for IN cord-023726-2fduzqyb 200 2 example example NN cord-023726-2fduzqyb 200 3 , , , cord-023726-2fduzqyb 200 4 the the DT cord-023726-2fduzqyb 200 5 T t NN cord-023726-2fduzqyb 200 6 - - HYPH cord-023726-2fduzqyb 200 7 even even RB cord-023726-2fduzqyb 200 8 bacteriophages bacteriophage NNS cord-023726-2fduzqyb 200 9 have have VBP cord-023726-2fduzqyb 200 10 a a DT cord-023726-2fduzqyb 200 11 large large JJ cord-023726-2fduzqyb 200 12 head head NN cord-023726-2fduzqyb 200 13 , , , cord-023726-2fduzqyb 200 14 which which WDT cord-023726-2fduzqyb 200 15 can can MD cord-023726-2fduzqyb 200 16 be be VB cord-023726-2fduzqyb 200 17 thought think VBN cord-023726-2fduzqyb 200 18 of of IN cord-023726-2fduzqyb 200 19 as as IN cord-023726-2fduzqyb 200 20 being be VBG cord-023726-2fduzqyb 200 21 formed form VBN cord-023726-2fduzqyb 200 22 of of IN cord-023726-2fduzqyb 200 23 two two CD cord-023726-2fduzqyb 200 24 hemi hemi NNP cord-023726-2fduzqyb 200 25 - - HYPH cord-023726-2fduzqyb 200 26 icosahedrons icosahedron NNS cord-023726-2fduzqyb 200 27 possessing possess VBG cord-023726-2fduzqyb 200 28 regular regular JJ cord-023726-2fduzqyb 200 29 icosahedral icosahedral JJ cord-023726-2fduzqyb 200 30 symmetry symmetry NN cord-023726-2fduzqyb 200 31 , , , cord-023726-2fduzqyb 200 32 which which WDT cord-023726-2fduzqyb 200 33 are be VBP cord-023726-2fduzqyb 200 34 elongated elongated JJ cord-023726-2fduzqyb 200 35 in in IN cord-023726-2fduzqyb 200 36 the the DT cord-023726-2fduzqyb 200 37 form form NN cord-023726-2fduzqyb 200 38 of of IN cord-023726-2fduzqyb 200 39 a a DT cord-023726-2fduzqyb 200 40 prolate prolate JJ cord-023726-2fduzqyb 200 41 ellipsoid ellipsoid NN cord-023726-2fduzqyb 200 42 by by IN cord-023726-2fduzqyb 200 43 subunits subunit NNS cord-023726-2fduzqyb 200 44 arranged arrange VBN cord-023726-2fduzqyb 200 45 in in IN cord-023726-2fduzqyb 200 46 a a DT cord-023726-2fduzqyb 200 47 regular regular JJ cord-023726-2fduzqyb 200 48 net net NN cord-023726-2fduzqyb 200 49 connecting connect VBG cord-023726-2fduzqyb 200 50 the the DT cord-023726-2fduzqyb 200 51 two two CD cord-023726-2fduzqyb 200 52 icosahedral icosahedral JJ cord-023726-2fduzqyb 200 53 ends end NNS cord-023726-2fduzqyb 200 54 of of IN cord-023726-2fduzqyb 200 55 the the DT cord-023726-2fduzqyb 200 56 head head NN cord-023726-2fduzqyb 200 57 of of IN cord-023726-2fduzqyb 200 58 the the DT cord-023726-2fduzqyb 200 59 virus virus NN cord-023726-2fduzqyb 200 60 . . . cord-023726-2fduzqyb 201 1 Many many JJ cord-023726-2fduzqyb 201 2 animal animal NN cord-023726-2fduzqyb 201 3 viruses virus NNS cord-023726-2fduzqyb 201 4 and and CC cord-023726-2fduzqyb 201 5 some some DT cord-023726-2fduzqyb 201 6 plant plant NN cord-023726-2fduzqyb 201 7 viruses virus NNS cord-023726-2fduzqyb 201 8 are be VBP cord-023726-2fduzqyb 201 9 enveloped envelop VBN cord-023726-2fduzqyb 201 10 ; ; : cord-023726-2fduzqyb 201 11 that that RB cord-023726-2fduzqyb 201 12 is is RB cord-023726-2fduzqyb 201 13 , , , cord-023726-2fduzqyb 201 14 they -PRON- PRP cord-023726-2fduzqyb 201 15 have have VBP cord-023726-2fduzqyb 201 16 a a DT cord-023726-2fduzqyb 201 17 lipid lipid NN cord-023726-2fduzqyb 201 18 - - HYPH cord-023726-2fduzqyb 201 19 containing contain VBG cord-023726-2fduzqyb 201 20 envelope envelope NN cord-023726-2fduzqyb 201 21 surrounding surround VBG cord-023726-2fduzqyb 201 22 a a DT cord-023726-2fduzqyb 201 23 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 201 24 . . . cord-023726-2fduzqyb 202 1 The the DT cord-023726-2fduzqyb 202 2 lipids lipid NNS cord-023726-2fduzqyb 202 3 are be VBP cord-023726-2fduzqyb 202 4 derived derive VBN cord-023726-2fduzqyb 202 5 from from IN cord-023726-2fduzqyb 202 6 the the DT cord-023726-2fduzqyb 202 7 host host NN cord-023726-2fduzqyb 202 8 cell cell NN cord-023726-2fduzqyb 202 9 . . . cord-023726-2fduzqyb 203 1 Although although IN cord-023726-2fduzqyb 203 2 there there EX cord-023726-2fduzqyb 203 3 is be VBZ cord-023726-2fduzqyb 203 4 some some DT cord-023726-2fduzqyb 203 5 selectivity selectivity NN cord-023726-2fduzqyb 203 6 and and CC cord-023726-2fduzqyb 203 7 reorganization reorganization NN cord-023726-2fduzqyb 203 8 of of IN cord-023726-2fduzqyb 203 9 lipids lipid NNS cord-023726-2fduzqyb 203 10 during during IN cord-023726-2fduzqyb 203 11 virus virus NN cord-023726-2fduzqyb 203 12 formation formation NN cord-023726-2fduzqyb 203 13 , , , cord-023726-2fduzqyb 203 14 the the DT cord-023726-2fduzqyb 203 15 lipid lipid NN cord-023726-2fduzqyb 203 16 composition composition NN cord-023726-2fduzqyb 203 17 in in IN cord-023726-2fduzqyb 203 18 general general JJ cord-023726-2fduzqyb 203 19 mirrors mirror NNS cord-023726-2fduzqyb 203 20 the the DT cord-023726-2fduzqyb 203 21 composition composition NN cord-023726-2fduzqyb 203 22 of of IN cord-023726-2fduzqyb 203 23 the the DT cord-023726-2fduzqyb 203 24 cellular cellular JJ cord-023726-2fduzqyb 203 25 membrane membrane NN cord-023726-2fduzqyb 203 26 from from IN cord-023726-2fduzqyb 203 27 which which WDT cord-023726-2fduzqyb 203 28 the the DT cord-023726-2fduzqyb 203 29 envelope envelope NN cord-023726-2fduzqyb 203 30 was be VBD cord-023726-2fduzqyb 203 31 derived derive VBN cord-023726-2fduzqyb 203 32 . . . cord-023726-2fduzqyb 204 1 However however RB cord-023726-2fduzqyb 204 2 , , , cord-023726-2fduzqyb 204 3 the the DT cord-023726-2fduzqyb 204 4 proteins protein NNS cord-023726-2fduzqyb 204 5 in in IN cord-023726-2fduzqyb 204 6 the the DT cord-023726-2fduzqyb 204 7 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 204 8 , , , cord-023726-2fduzqyb 204 9 which which WDT cord-023726-2fduzqyb 204 10 may may MD cord-023726-2fduzqyb 204 11 possess possess VB cord-023726-2fduzqyb 204 12 either either RB cord-023726-2fduzqyb 204 13 helical helical JJ cord-023726-2fduzqyb 204 14 or or CC cord-023726-2fduzqyb 204 15 icosahedral icosahedral JJ cord-023726-2fduzqyb 204 16 symmetry symmetry NN cord-023726-2fduzqyb 204 17 , , , cord-023726-2fduzqyb 204 18 and and CC cord-023726-2fduzqyb 204 19 the the DT cord-023726-2fduzqyb 204 20 proteins protein NNS cord-023726-2fduzqyb 204 21 in in IN cord-023726-2fduzqyb 204 22 the the DT cord-023726-2fduzqyb 204 23 envelope envelope NN cord-023726-2fduzqyb 204 24 are be VBP cord-023726-2fduzqyb 204 25 encoded encode VBN cord-023726-2fduzqyb 204 26 in in IN cord-023726-2fduzqyb 204 27 the the DT cord-023726-2fduzqyb 204 28 virus virus NN cord-023726-2fduzqyb 204 29 . . . cord-023726-2fduzqyb 205 1 The the DT cord-023726-2fduzqyb 205 2 protein protein NN cord-023726-2fduzqyb 205 3 - - HYPH cord-023726-2fduzqyb 205 4 protein protein NN cord-023726-2fduzqyb 205 5 interactions interaction NNS cord-023726-2fduzqyb 205 6 that that WDT cord-023726-2fduzqyb 205 7 are be VBP cord-023726-2fduzqyb 205 8 responsible responsible JJ cord-023726-2fduzqyb 205 9 for for IN cord-023726-2fduzqyb 205 10 assembly assembly NN cord-023726-2fduzqyb 205 11 of of IN cord-023726-2fduzqyb 205 12 the the DT cord-023726-2fduzqyb 205 13 mature mature JJ cord-023726-2fduzqyb 205 14 enveloped envelop VBN cord-023726-2fduzqyb 205 15 virions virion NNS cord-023726-2fduzqyb 205 16 differ differ VBP cord-023726-2fduzqyb 205 17 among among IN cord-023726-2fduzqyb 205 18 the the DT cord-023726-2fduzqyb 205 19 different different JJ cord-023726-2fduzqyb 205 20 families family NNS cord-023726-2fduzqyb 205 21 and and CC cord-023726-2fduzqyb 205 22 the the DT cord-023726-2fduzqyb 205 23 structures structure NNS cord-023726-2fduzqyb 205 24 of of IN cord-023726-2fduzqyb 205 25 the the DT cord-023726-2fduzqyb 205 26 resulting result VBG cord-023726-2fduzqyb 205 27 virions virion NNS cord-023726-2fduzqyb 205 28 differ differ VBP cord-023726-2fduzqyb 205 29 . . . cord-023726-2fduzqyb 206 1 The the DT cord-023726-2fduzqyb 206 2 virions virion NNS cord-023726-2fduzqyb 206 3 of of IN cord-023726-2fduzqyb 206 4 alphaviruses alphavirus NNS cord-023726-2fduzqyb 206 5 , , , cord-023726-2fduzqyb 206 6 and and CC cord-023726-2fduzqyb 206 7 of of IN cord-023726-2fduzqyb 206 8 flaviviruses flavivirus NNS cord-023726-2fduzqyb 206 9 , , , cord-023726-2fduzqyb 206 10 are be VBP cord-023726-2fduzqyb 206 11 uniform uniform JJ cord-023726-2fduzqyb 206 12 _SP cord-023726-2fduzqyb 207 1 The the DT cord-023726-2fduzqyb 207 2 essential essential JJ cord-023726-2fduzqyb 207 3 features feature NNS cord-023726-2fduzqyb 207 4 of of IN cord-023726-2fduzqyb 207 5 the the DT cord-023726-2fduzqyb 207 6 orbivirus orbivirus NN cord-023726-2fduzqyb 207 7 native native JJ cord-023726-2fduzqyb 207 8 core core NN cord-023726-2fduzqyb 207 9 particle particle NN cord-023726-2fduzqyb 207 10 . . . cord-023726-2fduzqyb 208 1 The the DT cord-023726-2fduzqyb 208 2 asymmetric asymmetric JJ cord-023726-2fduzqyb 208 3 unit unit NN cord-023726-2fduzqyb 208 4 is be VBZ cord-023726-2fduzqyb 208 5 indicated indicate VBN cord-023726-2fduzqyb 208 6 by by IN cord-023726-2fduzqyb 208 7 the the DT cord-023726-2fduzqyb 208 8 white white JJ cord-023726-2fduzqyb 208 9 lines line NNS cord-023726-2fduzqyb 208 10 forming form VBG cord-023726-2fduzqyb 208 11 a a DT cord-023726-2fduzqyb 208 12 triangle triangle NN cord-023726-2fduzqyb 208 13 and and CC cord-023726-2fduzqyb 208 14 the the DT cord-023726-2fduzqyb 208 15 fivefold fivefold NN cord-023726-2fduzqyb 208 16 , , , cord-023726-2fduzqyb 208 17 threefold threefold JJ cord-023726-2fduzqyb 208 18 , , , cord-023726-2fduzqyb 208 19 and and CC cord-023726-2fduzqyb 208 20 twofold twofold JJ cord-023726-2fduzqyb 208 21 axes axis NNS cord-023726-2fduzqyb 208 22 are be VBP cord-023726-2fduzqyb 208 23 marked mark VBN cord-023726-2fduzqyb 208 24 . . . cord-023726-2fduzqyb 209 1 ( ( -LRB- cord-023726-2fduzqyb 209 2 A a NN cord-023726-2fduzqyb 209 3 ) ) -RRB- cord-023726-2fduzqyb 209 4 The the DT cord-023726-2fduzqyb 209 5 inner inner JJ cord-023726-2fduzqyb 209 6 capsid capsid NN cord-023726-2fduzqyb 209 7 layer layer NN cord-023726-2fduzqyb 209 8 of of IN cord-023726-2fduzqyb 209 9 the the DT cord-023726-2fduzqyb 209 10 bluetongue bluetongue NN cord-023726-2fduzqyb 209 11 virus virus NN cord-023726-2fduzqyb 209 12 ( ( -LRB- cord-023726-2fduzqyb 209 13 BTV BTV NNP cord-023726-2fduzqyb 209 14 ) ) -RRB- cord-023726-2fduzqyb 209 15 core core NN cord-023726-2fduzqyb 209 16 is be VBZ cord-023726-2fduzqyb 209 17 composed compose VBN cord-023726-2fduzqyb 209 18 of of IN cord-023726-2fduzqyb 209 19 120 120 CD cord-023726-2fduzqyb 209 20 molecules molecule NNS cord-023726-2fduzqyb 209 21 of of IN cord-023726-2fduzqyb 209 22 VP3 VP3 NNP cord-023726-2fduzqyb 209 23 , , , cord-023726-2fduzqyb 209 24 arranged arrange VBN cord-023726-2fduzqyb 209 25 in in IN cord-023726-2fduzqyb 209 26 what what WP cord-023726-2fduzqyb 209 27 has have VBZ cord-023726-2fduzqyb 209 28 been be VBN cord-023726-2fduzqyb 209 29 called call VBN cord-023726-2fduzqyb 209 30 T=2 T=2 NNP cord-023726-2fduzqyb 209 31 symmetry symmetry NN cord-023726-2fduzqyb 209 32 . . . cord-023726-2fduzqyb 210 1 Note note VB cord-023726-2fduzqyb 210 2 the the DT cord-023726-2fduzqyb 210 3 green green JJ cord-023726-2fduzqyb 210 4 subunit subunit NN cord-023726-2fduzqyb 210 5 A A NNP cord-023726-2fduzqyb 210 6 and and CC cord-023726-2fduzqyb 210 7 the the DT cord-023726-2fduzqyb 210 8 red red JJ cord-023726-2fduzqyb 210 9 subunit subunit NN cord-023726-2fduzqyb 210 10 B B NNP cord-023726-2fduzqyb 210 11 which which WDT cord-023726-2fduzqyb 210 12 fill fill VBP cord-023726-2fduzqyb 210 13 the the DT cord-023726-2fduzqyb 210 14 asymmetric asymmetric JJ cord-023726-2fduzqyb 210 15 unit unit NN cord-023726-2fduzqyb 210 16 . . . cord-023726-2fduzqyb 211 1 ( ( -LRB- cord-023726-2fduzqyb 211 2 B b NN cord-023726-2fduzqyb 211 3 ) ) -RRB- cord-023726-2fduzqyb 212 1 The the DT cord-023726-2fduzqyb 212 2 core core NN cord-023726-2fduzqyb 212 3 surface surface NN cord-023726-2fduzqyb 212 4 layer layer NN cord-023726-2fduzqyb 212 5 is be VBZ cord-023726-2fduzqyb 212 6 composed compose VBN cord-023726-2fduzqyb 212 7 of of IN cord-023726-2fduzqyb 212 8 780 780 CD cord-023726-2fduzqyb 212 9 copies copy NNS cord-023726-2fduzqyb 212 10 of of IN cord-023726-2fduzqyb 212 11 VP7 vp7 NN cord-023726-2fduzqyb 212 12 arranged arrange VBD cord-023726-2fduzqyb 212 13 as as IN cord-023726-2fduzqyb 212 14 260 260 CD cord-023726-2fduzqyb 212 15 trimers trimer NNS cord-023726-2fduzqyb 212 16 , , , cord-023726-2fduzqyb 212 17 with with IN cord-023726-2fduzqyb 212 18 T=13 T=13 NNP cord-023726-2fduzqyb 212 19 symmetry symmetry NN cord-023726-2fduzqyb 212 20 . . . cord-023726-2fduzqyb 213 1 The the DT cord-023726-2fduzqyb 213 2 asymmetric asymmetric JJ cord-023726-2fduzqyb 213 3 unit unit NN cord-023726-2fduzqyb 213 4 contains contain VBZ cord-023726-2fduzqyb 213 5 13 13 CD cord-023726-2fduzqyb 213 6 copies copy NNS cord-023726-2fduzqyb 213 7 of of IN cord-023726-2fduzqyb 213 8 VP7 vp7 NN cord-023726-2fduzqyb 213 9 , , , cord-023726-2fduzqyb 213 10 arranged arrange VBD cord-023726-2fduzqyb 213 11 as as IN cord-023726-2fduzqyb 213 12 five five CD cord-023726-2fduzqyb 213 13 trimers trimer NNS cord-023726-2fduzqyb 213 14 , , , cord-023726-2fduzqyb 213 15 labeled label VBN cord-023726-2fduzqyb 213 16 P p NN cord-023726-2fduzqyb 213 17 , , , cord-023726-2fduzqyb 213 18 Q Q NNP cord-023726-2fduzqyb 213 19 , , , cord-023726-2fduzqyb 213 20 R r NN cord-023726-2fduzqyb 213 21 , , , cord-023726-2fduzqyb 213 22 S S NNP cord-023726-2fduzqyb 213 23 , , , cord-023726-2fduzqyb 213 24 and and CC cord-023726-2fduzqyb 213 25 T T NNP cord-023726-2fduzqyb 213 26 , , , cord-023726-2fduzqyb 213 27 with with IN cord-023726-2fduzqyb 213 28 each each DT cord-023726-2fduzqyb 213 29 trimer trimer NN cord-023726-2fduzqyb 213 30 a a DT cord-023726-2fduzqyb 213 31 different different JJ cord-023726-2fduzqyb 213 32 color color NN cord-023726-2fduzqyb 213 33 . . . cord-023726-2fduzqyb 214 1 Trimer Trimer NNP cord-023726-2fduzqyb 214 2 " " `` cord-023726-2fduzqyb 214 3 T T NNP cord-023726-2fduzqyb 214 4 " " '' cord-023726-2fduzqyb 214 5 in in IN cord-023726-2fduzqyb 214 6 blue blue JJ cord-023726-2fduzqyb 214 7 sits sit VBZ cord-023726-2fduzqyb 214 8 on on IN cord-023726-2fduzqyb 214 9 the the DT cord-023726-2fduzqyb 214 10 icosahedral icosahedral JJ cord-023726-2fduzqyb 214 11 threefold threefold JJ cord-023726-2fduzqyb 214 12 axis axis NN cord-023726-2fduzqyb 214 13 and and CC cord-023726-2fduzqyb 214 14 thus thus RB cord-023726-2fduzqyb 214 15 contributes contribute VBZ cord-023726-2fduzqyb 214 16 only only RB cord-023726-2fduzqyb 214 17 a a DT cord-023726-2fduzqyb 214 18 monomer monomer NN cord-023726-2fduzqyb 214 19 to to IN cord-023726-2fduzqyb 214 20 the the DT cord-023726-2fduzqyb 214 21 asymmetric asymmetric JJ cord-023726-2fduzqyb 214 22 unit unit NN cord-023726-2fduzqyb 214 23 . . . cord-023726-2fduzqyb 215 1 From from IN cord-023726-2fduzqyb 215 2 Granoff Granoff NNP cord-023726-2fduzqyb 215 3 and and CC cord-023726-2fduzqyb 215 4 Webster Webster NNP cord-023726-2fduzqyb 215 5 ( ( -LRB- cord-023726-2fduzqyb 215 6 1999 1999 CD cord-023726-2fduzqyb 215 7 ) ) -RRB- cord-023726-2fduzqyb 215 8 , , , cord-023726-2fduzqyb 215 9 Color Color NNP cord-023726-2fduzqyb 215 10 Plate Plate NNP cord-023726-2fduzqyb 215 11 17 17 CD cord-023726-2fduzqyb 215 12 . . . cord-023726-2fduzqyb 216 1 structures structure NNS cord-023726-2fduzqyb 216 2 that that WDT cord-023726-2fduzqyb 216 3 possess possess VBP cord-023726-2fduzqyb 216 4 icosahedral icosahedral JJ cord-023726-2fduzqyb 216 5 symmetry symmetry NN cord-023726-2fduzqyb 216 6 . . . cord-023726-2fduzqyb 217 1 Poxviruses poxvirus NNS cord-023726-2fduzqyb 217 2 , , , cord-023726-2fduzqyb 217 3 rhabdoviruses rhabdovirus NNS cord-023726-2fduzqyb 217 4 , , , cord-023726-2fduzqyb 217 5 and and CC cord-023726-2fduzqyb 217 6 retroviruses retrovirus NNS cord-023726-2fduzqyb 217 7 also also RB cord-023726-2fduzqyb 217 8 appear appear VBP cord-023726-2fduzqyb 217 9 to to TO cord-023726-2fduzqyb 217 10 have have VB cord-023726-2fduzqyb 217 11 a a DT cord-023726-2fduzqyb 217 12 regular regular JJ cord-023726-2fduzqyb 217 13 structure structure NN cord-023726-2fduzqyb 217 14 , , , cord-023726-2fduzqyb 217 15 but but CC cord-023726-2fduzqyb 217 16 there there EX cord-023726-2fduzqyb 217 17 is be VBZ cord-023726-2fduzqyb 217 18 flexibility flexibility NN cord-023726-2fduzqyb 217 19 in in IN cord-023726-2fduzqyb 217 20 the the DT cord-023726-2fduzqyb 217 21 composition composition NN cord-023726-2fduzqyb 217 22 of of IN cord-023726-2fduzqyb 217 23 the the DT cord-023726-2fduzqyb 217 24 particle particle NN cord-023726-2fduzqyb 217 25 and and CC cord-023726-2fduzqyb 217 26 the the DT cord-023726-2fduzqyb 217 27 mature mature JJ cord-023726-2fduzqyb 217 28 virions virion NNS cord-023726-2fduzqyb 217 29 do do VBP cord-023726-2fduzqyb 217 30 not not RB cord-023726-2fduzqyb 217 31 possess possess VB cord-023726-2fduzqyb 217 32 icosahedral icosahedral JJ cord-023726-2fduzqyb 217 33 symmetry symmetry NN cord-023726-2fduzqyb 217 34 . . . cord-023726-2fduzqyb 218 1 The the DT cord-023726-2fduzqyb 218 2 herpesvirus herpesvirus NN cord-023726-2fduzqyb 218 3 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 218 4 is be VBZ cord-023726-2fduzqyb 218 5 a a DT cord-023726-2fduzqyb 218 6 regular regular JJ cord-023726-2fduzqyb 218 7 icosahedral icosahedral JJ cord-023726-2fduzqyb 218 8 structure structure NN cord-023726-2fduzqyb 218 9 ( ( -LRB- cord-023726-2fduzqyb 218 10 Fig Fig NNP cord-023726-2fduzqyb 218 11 . . . cord-023726-2fduzqyb 218 12 2.5 2.5 CD cord-023726-2fduzqyb 218 13 ) ) -RRB- cord-023726-2fduzqyb 218 14 , , , cord-023726-2fduzqyb 218 15 but but CC cord-023726-2fduzqyb 218 16 the the DT cord-023726-2fduzqyb 218 17 enveloped envelop VBN cord-023726-2fduzqyb 218 18 herpesvirions herpesvirion NNS cord-023726-2fduzqyb 218 19 are be VBP cord-023726-2fduzqyb 218 20 not not RB cord-023726-2fduzqyb 218 21 regular regular JJ cord-023726-2fduzqyb 218 22 . . . cord-023726-2fduzqyb 219 1 Other other JJ cord-023726-2fduzqyb 219 2 enveloped envelop VBN cord-023726-2fduzqyb 219 3 viruses virus NNS cord-023726-2fduzqyb 219 4 are be VBP cord-023726-2fduzqyb 219 5 irregular irregular JJ cord-023726-2fduzqyb 219 6 , , , cord-023726-2fduzqyb 219 7 often often RB cord-023726-2fduzqyb 219 8 pleiomorphic pleiomorphic NNP cord-023726-2fduzqyb 219 9 , , , cord-023726-2fduzqyb 219 10 and and CC cord-023726-2fduzqyb 219 11 are be VBP cord-023726-2fduzqyb 219 12 heterogeneous heterogeneous JJ cord-023726-2fduzqyb 219 13 in in IN cord-023726-2fduzqyb 219 14 composition composition NN cord-023726-2fduzqyb 219 15 to to IN cord-023726-2fduzqyb 219 16 a a DT cord-023726-2fduzqyb 219 17 greater great JJR cord-023726-2fduzqyb 219 18 or or CC cord-023726-2fduzqyb 219 19 lesser less JJR cord-023726-2fduzqyb 219 20 extent extent NN cord-023726-2fduzqyb 219 21 . . . cord-023726-2fduzqyb 220 1 The the DT cord-023726-2fduzqyb 220 2 structures structure NNS cord-023726-2fduzqyb 220 3 of of IN cord-023726-2fduzqyb 220 4 different different JJ cord-023726-2fduzqyb 220 5 enveloped envelop VBN cord-023726-2fduzqyb 220 6 viruses virus NNS cord-023726-2fduzqyb 220 7 that that WDT cord-023726-2fduzqyb 220 8 illustrate illustrate VBP cord-023726-2fduzqyb 220 9 these these DT cord-023726-2fduzqyb 220 10 various various JJ cord-023726-2fduzqyb 220 11 points point NNS cord-023726-2fduzqyb 220 12 are be VBP cord-023726-2fduzqyb 220 13 described describe VBN cord-023726-2fduzqyb 220 14 next next RB cord-023726-2fduzqyb 220 15 . . . cord-023726-2fduzqyb 221 1 The the DT cord-023726-2fduzqyb 221 2 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 221 3 of of IN cord-023726-2fduzqyb 221 4 enveloped envelop VBN cord-023726-2fduzqyb 221 5 RNA RNA NNP cord-023726-2fduzqyb 221 6 viruses virus NNS cord-023726-2fduzqyb 221 7 are be VBP cord-023726-2fduzqyb 221 8 fairly fairly RB cord-023726-2fduzqyb 221 9 simple simple JJ cord-023726-2fduzqyb 221 10 structures structure NNS cord-023726-2fduzqyb 221 11 that that WDT cord-023726-2fduzqyb 221 12 contain contain VBP cord-023726-2fduzqyb 221 13 only only RB cord-023726-2fduzqyb 221 14 one one CD cord-023726-2fduzqyb 221 15 major major JJ cord-023726-2fduzqyb 221 16 structural structural JJ cord-023726-2fduzqyb 221 17 protein protein NN cord-023726-2fduzqyb 221 18 , , , cord-023726-2fduzqyb 221 19 often often RB cord-023726-2fduzqyb 221 20 referred refer VBD cord-023726-2fduzqyb 221 21 to to IN cord-023726-2fduzqyb 221 22 as as IN cord-023726-2fduzqyb 221 23 the the DT cord-023726-2fduzqyb 221 24 nucleocapsid nucleocapsid NNP cord-023726-2fduzqyb 221 25 protein protein NNP cord-023726-2fduzqyb 221 26 or or CC cord-023726-2fduzqyb 221 27 core core NN cord-023726-2fduzqyb 221 28 protein protein NN cord-023726-2fduzqyb 221 29 . . . cord-023726-2fduzqyb 222 1 This this DT cord-023726-2fduzqyb 222 2 protein protein NN cord-023726-2fduzqyb 222 3 is be VBZ cord-023726-2fduzqyb 222 4 usually usually RB cord-023726-2fduzqyb 222 5 quite quite RB cord-023726-2fduzqyb 222 6 basic basic JJ cord-023726-2fduzqyb 222 7 or or CC cord-023726-2fduzqyb 222 8 has have VBZ cord-023726-2fduzqyb 222 9 a a DT cord-023726-2fduzqyb 222 10 basic basic JJ cord-023726-2fduzqyb 222 11 domain domain NN cord-023726-2fduzqyb 222 12 . . . cord-023726-2fduzqyb 223 1 It -PRON- PRP cord-023726-2fduzqyb 223 2 binds bind VBZ cord-023726-2fduzqyb 223 3 to to IN cord-023726-2fduzqyb 223 4 the the DT cord-023726-2fduzqyb 223 5 viral viral JJ cord-023726-2fduzqyb 223 6 RNA RNA NNP cord-023726-2fduzqyb 223 7 and and CC cord-023726-2fduzqyb 223 8 encapsidates encapsidate VBZ cord-023726-2fduzqyb 223 9 it -PRON- PRP cord-023726-2fduzqyb 223 10 to to TO cord-023726-2fduzqyb 223 11 form form VB cord-023726-2fduzqyb 223 12 the the DT cord-023726-2fduzqyb 223 13 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 223 14 . . . cord-023726-2fduzqyb 224 1 For for IN cord-023726-2fduzqyb 224 2 most most JJS cord-023726-2fduzqyb 224 3 RNA RNA NNP cord-023726-2fduzqyb 224 4 viruses virus NNS cord-023726-2fduzqyb 224 5 , , , cord-023726-2fduzqyb 224 6 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 224 7 can can MD cord-023726-2fduzqyb 224 8 be be VB cord-023726-2fduzqyb 224 9 recognized recognize VBN cord-023726-2fduzqyb 224 10 as as IN cord-023726-2fduzqyb 224 11 distinct distinct JJ cord-023726-2fduzqyb 224 12 structures structure NNS cord-023726-2fduzqyb 224 13 within within IN cord-023726-2fduzqyb 224 14 the the DT cord-023726-2fduzqyb 224 15 infected infected JJ cord-023726-2fduzqyb 224 16 cell cell NN cord-023726-2fduzqyb 224 17 and and CC cord-023726-2fduzqyb 224 18 can can MD cord-023726-2fduzqyb 224 19 be be VB cord-023726-2fduzqyb 224 20 isolated isolate VBN cord-023726-2fduzqyb 224 21 from from IN cord-023726-2fduzqyb 224 22 virions virion NNS cord-023726-2fduzqyb 224 23 by by IN cord-023726-2fduzqyb 224 24 treatment treatment NN cord-023726-2fduzqyb 224 25 with with IN cord-023726-2fduzqyb 224 26 detergents detergent NNS cord-023726-2fduzqyb 224 27 that that WDT cord-023726-2fduzqyb 224 28 dissolve dissolve VBP cord-023726-2fduzqyb 224 29 the the DT cord-023726-2fduzqyb 224 30 envelope envelope NN cord-023726-2fduzqyb 224 31 . . . cord-023726-2fduzqyb 225 1 The the DT cord-023726-2fduzqyb 225 2 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 225 3 of of IN cord-023726-2fduzqyb 225 4 alphaviruses alphaviruses NNP cord-023726-2fduzqyb 225 5 , , , cord-023726-2fduzqyb 225 6 and and CC cord-023726-2fduzqyb 225 7 probably probably RB cord-023726-2fduzqyb 225 8 flaviviruses flaviviruse VBZ cord-023726-2fduzqyb 225 9 and and CC cord-023726-2fduzqyb 225 10 arteriviruses arteriviruse NNS cord-023726-2fduzqyb 225 11 as as RB cord-023726-2fduzqyb 225 12 well well RB cord-023726-2fduzqyb 225 13 , , , cord-023726-2fduzqyb 225 14 are be VBP cord-023726-2fduzqyb 225 15 regular regular JJ cord-023726-2fduzqyb 225 16 icosahedral icosahedral JJ cord-023726-2fduzqyb 225 17 structures structure NNS cord-023726-2fduzqyb 225 18 , , , cord-023726-2fduzqyb 225 19 and and CC cord-023726-2fduzqyb 225 20 there there EX cord-023726-2fduzqyb 225 21 are be VBP cord-023726-2fduzqyb 225 22 no no DT cord-023726-2fduzqyb 225 23 other other JJ cord-023726-2fduzqyb 225 24 proteins protein NNS cord-023726-2fduzqyb 225 25 within within IN cord-023726-2fduzqyb 225 26 the the DT cord-023726-2fduzqyb 225 27 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 225 28 other other JJ cord-023726-2fduzqyb 225 29 than than IN cord-023726-2fduzqyb 225 30 the the DT cord-023726-2fduzqyb 225 31 nucleocapsid nucleocapsid NNP cord-023726-2fduzqyb 225 32 protein protein NN cord-023726-2fduzqyb 225 33 . . . cord-023726-2fduzqyb 226 1 In in IN cord-023726-2fduzqyb 226 2 contrast contrast NN cord-023726-2fduzqyb 226 3 , , , cord-023726-2fduzqyb 226 4 the the DT cord-023726-2fduzqyb 226 5 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 226 6 of of IN cord-023726-2fduzqyb 226 7 all all DT cord-023726-2fduzqyb 226 8 minus minus JJ cord-023726-2fduzqyb 226 9 - - HYPH cord-023726-2fduzqyb 226 10 strand strand NN cord-023726-2fduzqyb 226 11 viruses virus NNS cord-023726-2fduzqyb 226 12 are be VBP cord-023726-2fduzqyb 226 13 helical helical JJ cord-023726-2fduzqyb 226 14 and and CC cord-023726-2fduzqyb 226 15 contain contain VBP cord-023726-2fduzqyb 226 16 , , , cord-023726-2fduzqyb 226 17 in in IN cord-023726-2fduzqyb 226 18 addition addition NN cord-023726-2fduzqyb 226 19 to to IN cord-023726-2fduzqyb 226 20 the the DT cord-023726-2fduzqyb 226 21 major major JJ cord-023726-2fduzqyb 226 22 nucleocapsid nucleocapsid NNP cord-023726-2fduzqyb 226 23 protein protein NN cord-023726-2fduzqyb 226 24 , , , cord-023726-2fduzqyb 226 25 two two CD cord-023726-2fduzqyb 226 26 or or CC cord-023726-2fduzqyb 226 27 more more JJR cord-023726-2fduzqyb 226 28 minor minor JJ cord-023726-2fduzqyb 226 29 proteins protein NNS cord-023726-2fduzqyb 226 30 that that WDT cord-023726-2fduzqyb 226 31 possess possess VBP cord-023726-2fduzqyb 226 32 enzymatic enzymatic JJ cord-023726-2fduzqyb 226 33 activity activity NN cord-023726-2fduzqyb 226 34 . . . cord-023726-2fduzqyb 227 1 As as IN cord-023726-2fduzqyb 227 2 described describe VBN cord-023726-2fduzqyb 227 3 , , , cord-023726-2fduzqyb 227 4 the the DT cord-023726-2fduzqyb 227 5 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 227 6 of of IN cord-023726-2fduzqyb 227 7 minus minus JJ cord-023726-2fduzqyb 227 8 - - HYPH cord-023726-2fduzqyb 227 9 strand strand NN cord-023726-2fduzqyb 227 10 RNA RNA NNP cord-023726-2fduzqyb 227 11 viruses virus NNS cord-023726-2fduzqyb 227 12 remain remain VBP cord-023726-2fduzqyb 227 13 intact intact JJ cord-023726-2fduzqyb 227 14 within within IN cord-023726-2fduzqyb 227 15 the the DT cord-023726-2fduzqyb 227 16 cell cell NN cord-023726-2fduzqyb 227 17 during during IN cord-023726-2fduzqyb 227 18 the the DT cord-023726-2fduzqyb 227 19 entire entire JJ cord-023726-2fduzqyb 227 20 infection infection NN cord-023726-2fduzqyb 227 21 cycle cycle NN cord-023726-2fduzqyb 227 22 and and CC cord-023726-2fduzqyb 227 23 serve serve VBP cord-023726-2fduzqyb 227 24 as as IN cord-023726-2fduzqyb 227 25 machines machine NNS cord-023726-2fduzqyb 227 26 that that WDT cord-023726-2fduzqyb 227 27 make make VBP cord-023726-2fduzqyb 227 28 viral viral JJ cord-023726-2fduzqyb 227 29 RNA RNA NNP cord-023726-2fduzqyb 227 30 . . . cord-023726-2fduzqyb 228 1 The the DT cord-023726-2fduzqyb 228 2 coronaviruses coronaviruse NNS cord-023726-2fduzqyb 228 3 also also RB cord-023726-2fduzqyb 228 4 have have VBP cord-023726-2fduzqyb 228 5 helical helical JJ cord-023726-2fduzqyb 228 6 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 228 7 , , , cord-023726-2fduzqyb 228 8 but but CC cord-023726-2fduzqyb 228 9 being be VBG cord-023726-2fduzqyb 228 10 plus plus JJ cord-023726-2fduzqyb 228 11 - - HYPH cord-023726-2fduzqyb 228 12 strand strand NN cord-023726-2fduzqyb 228 13 RNA RNA NNP cord-023726-2fduzqyb 228 14 viruses virus NNS cord-023726-2fduzqyb 229 1 they -PRON- PRP cord-023726-2fduzqyb 229 2 do do VBP cord-023726-2fduzqyb 229 3 not not RB cord-023726-2fduzqyb 229 4 need need VB cord-023726-2fduzqyb 229 5 to to TO cord-023726-2fduzqyb 229 6 carry carry VB cord-023726-2fduzqyb 229 7 enzymes enzyme NNS cord-023726-2fduzqyb 229 8 in in IN cord-023726-2fduzqyb 229 9 the the DT cord-023726-2fduzqyb 229 10 virion virion NN cord-023726-2fduzqyb 229 11 to to TO cord-023726-2fduzqyb 229 12 initiate initiate VB cord-023726-2fduzqyb 229 13 infection infection NN cord-023726-2fduzqyb 229 14 . . . cord-023726-2fduzqyb 230 1 The the DT cord-023726-2fduzqyb 230 2 helical helical JJ cord-023726-2fduzqyb 230 3 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 230 4 of of IN cord-023726-2fduzqyb 230 5 ( ( -LRB- cord-023726-2fduzqyb 230 6 − − NNP cord-023726-2fduzqyb 230 7 ) ) -RRB- cord-023726-2fduzqyb 231 1 RNA RNA NNP cord-023726-2fduzqyb 231 2 viruses virus NNS cord-023726-2fduzqyb 231 3 appear appear VBP cord-023726-2fduzqyb 231 4 disordered disordered JJ cord-023726-2fduzqyb 231 5 within within IN cord-023726-2fduzqyb 231 6 the the DT cord-023726-2fduzqyb 231 7 envelope envelope NN cord-023726-2fduzqyb 231 8 of of IN cord-023726-2fduzqyb 231 9 all all DT cord-023726-2fduzqyb 231 10 viruses virus NNS cord-023726-2fduzqyb 231 11 except except IN cord-023726-2fduzqyb 231 12 the the DT cord-023726-2fduzqyb 231 13 rhabdoviruses rhabdovirus NNS cord-023726-2fduzqyb 231 14 , , , cord-023726-2fduzqyb 231 15 in in IN cord-023726-2fduzqyb 231 16 which which WDT cord-023726-2fduzqyb 231 17 they -PRON- PRP cord-023726-2fduzqyb 231 18 are be VBP cord-023726-2fduzqyb 231 19 coiled coil VBN cord-023726-2fduzqyb 231 20 in in IN cord-023726-2fduzqyb 231 21 a a DT cord-023726-2fduzqyb 231 22 regular regular JJ cord-023726-2fduzqyb 231 23 fashion fashion NN cord-023726-2fduzqyb 231 24 ( ( -LRB- cord-023726-2fduzqyb 231 25 see see VB cord-023726-2fduzqyb 231 26 later later RB cord-023726-2fduzqyb 231 27 ) ) -RRB- cord-023726-2fduzqyb 231 28 . . . cord-023726-2fduzqyb 232 1 The the DT cord-023726-2fduzqyb 232 2 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 232 3 of of IN cord-023726-2fduzqyb 232 4 retroviruses retrovirus NNS cord-023726-2fduzqyb 232 5 also also RB cord-023726-2fduzqyb 232 6 appear appear VBP cord-023726-2fduzqyb 232 7 to to TO cord-023726-2fduzqyb 232 8 be be VB cord-023726-2fduzqyb 232 9 fairly fairly RB cord-023726-2fduzqyb 232 10 simple simple JJ cord-023726-2fduzqyb 232 11 structures structure NNS cord-023726-2fduzqyb 232 12 . . . cord-023726-2fduzqyb 233 1 They -PRON- PRP cord-023726-2fduzqyb 233 2 are be VBP cord-023726-2fduzqyb 233 3 formed form VBN cord-023726-2fduzqyb 233 4 from from IN cord-023726-2fduzqyb 233 5 one one CD cord-023726-2fduzqyb 233 6 major major JJ cord-023726-2fduzqyb 233 7 precursor precursor NN cord-023726-2fduzqyb 233 8 protein protein NN cord-023726-2fduzqyb 233 9 , , , cord-023726-2fduzqyb 233 10 the the DT cord-023726-2fduzqyb 233 11 Gag Gag NNP cord-023726-2fduzqyb 233 12 polyprotein polyprotein NN cord-023726-2fduzqyb 233 13 , , , cord-023726-2fduzqyb 233 14 that that WDT cord-023726-2fduzqyb 233 15 is be VBZ cord-023726-2fduzqyb 233 16 cleaved cleave VBN cord-023726-2fduzqyb 233 17 during during IN cord-023726-2fduzqyb 233 18 maturation maturation NN cord-023726-2fduzqyb 233 19 into into IN cord-023726-2fduzqyb 233 20 four four CD cord-023726-2fduzqyb 233 21 or or CC cord-023726-2fduzqyb 233 22 five five CD cord-023726-2fduzqyb 233 23 components component NNS cord-023726-2fduzqyb 233 24 . . . cord-023726-2fduzqyb 234 1 The the DT cord-023726-2fduzqyb 234 2 precursor precursor NN cord-023726-2fduzqyb 234 3 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 234 4 is be VBZ cord-023726-2fduzqyb 234 5 spherically spherically RB cord-023726-2fduzqyb 234 6 symmetric symmetric JJ cord-023726-2fduzqyb 234 7 but but CC cord-023726-2fduzqyb 234 8 lacks lack VBZ cord-023726-2fduzqyb 234 9 icosahedral icosahedral JJ cord-023726-2fduzqyb 234 10 symmetry symmetry NN cord-023726-2fduzqyb 234 11 . . . cord-023726-2fduzqyb 235 1 The the DT cord-023726-2fduzqyb 235 2 mature mature JJ cord-023726-2fduzqyb 235 3 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 235 4 produced produce VBN cord-023726-2fduzqyb 235 5 by by IN cord-023726-2fduzqyb 235 6 cleavage cleavage NN cord-023726-2fduzqyb 235 7 of of IN cord-023726-2fduzqyb 235 8 Gag Gag NNP cord-023726-2fduzqyb 235 9 may may MD cord-023726-2fduzqyb 235 10 or or CC cord-023726-2fduzqyb 235 11 may may MD cord-023726-2fduzqyb 235 12 not not RB cord-023726-2fduzqyb 235 13 be be VB cord-023726-2fduzqyb 235 14 spherical spherical JJ cord-023726-2fduzqyb 235 15 symmetric symmetric JJ cord-023726-2fduzqyb 235 16 . . . cord-023726-2fduzqyb 236 1 The the DT cord-023726-2fduzqyb 236 2 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 236 3 also also RB cord-023726-2fduzqyb 236 4 contains contain VBZ cord-023726-2fduzqyb 236 5 minor minor JJ cord-023726-2fduzqyb 236 6 proteins protein NNS cord-023726-2fduzqyb 236 7 , , , cord-023726-2fduzqyb 236 8 produced produce VBN cord-023726-2fduzqyb 236 9 by by IN cord-023726-2fduzqyb 236 10 cleavage cleavage NN cord-023726-2fduzqyb 236 11 of of IN cord-023726-2fduzqyb 236 12 Gag gag NN cord-023726-2fduzqyb 236 13 - - HYPH cord-023726-2fduzqyb 236 14 Pro pro JJ cord-023726-2fduzqyb 236 15 - - JJ cord-023726-2fduzqyb 236 16 Pol Pol NNP cord-023726-2fduzqyb 236 17 , , , cord-023726-2fduzqyb 236 18 as as IN cord-023726-2fduzqyb 236 19 described describe VBN cord-023726-2fduzqyb 236 20 in in IN cord-023726-2fduzqyb 236 21 Chapter chapter NN cord-023726-2fduzqyb 236 22 1 1 CD cord-023726-2fduzqyb 236 23 . . . cord-023726-2fduzqyb 237 1 These these DT cord-023726-2fduzqyb 237 2 minor minor JJ cord-023726-2fduzqyb 237 3 proteins protein NNS cord-023726-2fduzqyb 237 4 include include VBP cord-023726-2fduzqyb 237 5 the the DT cord-023726-2fduzqyb 237 6 protease protease NN cord-023726-2fduzqyb 237 7 , , , cord-023726-2fduzqyb 237 8 RT RT NNP cord-023726-2fduzqyb 237 9 , , , cord-023726-2fduzqyb 237 10 RNase RNase NNP cord-023726-2fduzqyb 237 11 H H NNP cord-023726-2fduzqyb 237 12 , , , cord-023726-2fduzqyb 237 13 and and CC cord-023726-2fduzqyb 237 14 integrase integrase NN cord-023726-2fduzqyb 237 15 that that WDT cord-023726-2fduzqyb 237 16 are be VBP cord-023726-2fduzqyb 237 17 required require VBN cord-023726-2fduzqyb 237 18 to to TO cord-023726-2fduzqyb 237 19 cleave cleave VB cord-023726-2fduzqyb 237 20 the the DT cord-023726-2fduzqyb 237 21 polyprotein polyprotein JJ cord-023726-2fduzqyb 237 22 precursors precursor NNS cord-023726-2fduzqyb 237 23 , , , cord-023726-2fduzqyb 237 24 to to TO cord-023726-2fduzqyb 237 25 make make VB cord-023726-2fduzqyb 237 26 a a DT cord-023726-2fduzqyb 237 27 cDNA cdna JJ cord-023726-2fduzqyb 237 28 copy copy NN cord-023726-2fduzqyb 237 29 of of IN cord-023726-2fduzqyb 237 30 the the DT cord-023726-2fduzqyb 237 31 viral viral JJ cord-023726-2fduzqyb 237 32 RNA RNA NNP cord-023726-2fduzqyb 237 33 , , , cord-023726-2fduzqyb 237 34 and and CC cord-023726-2fduzqyb 237 35 to to TO cord-023726-2fduzqyb 237 36 integrate integrate VB cord-023726-2fduzqyb 237 37 this this DT cord-023726-2fduzqyb 237 38 cDNA cdna NN cord-023726-2fduzqyb 237 39 copy copy NN cord-023726-2fduzqyb 237 40 into into IN cord-023726-2fduzqyb 237 41 the the DT cord-023726-2fduzqyb 237 42 host host NN cord-023726-2fduzqyb 237 43 chromosome chromosome NN cord-023726-2fduzqyb 237 44 . . . cord-023726-2fduzqyb 238 1 The the DT cord-023726-2fduzqyb 238 2 two two CD cord-023726-2fduzqyb 238 3 families family NNS cord-023726-2fduzqyb 238 4 of of IN cord-023726-2fduzqyb 238 5 enveloped envelop VBN cord-023726-2fduzqyb 238 6 DNA dna NN cord-023726-2fduzqyb 238 7 viruses virus NNS cord-023726-2fduzqyb 238 8 that that WDT cord-023726-2fduzqyb 238 9 we -PRON- PRP cord-023726-2fduzqyb 238 10 consider consider VBP cord-023726-2fduzqyb 238 11 here here RB cord-023726-2fduzqyb 238 12 , , , cord-023726-2fduzqyb 238 13 the the DT cord-023726-2fduzqyb 238 14 poxviruses poxvirus NNS cord-023726-2fduzqyb 238 15 and and CC cord-023726-2fduzqyb 238 16 the the DT cord-023726-2fduzqyb 238 17 herpesviruses herpesviruse NNS cord-023726-2fduzqyb 238 18 , , , cord-023726-2fduzqyb 238 19 contain contain VBP cord-023726-2fduzqyb 238 20 large large JJ cord-023726-2fduzqyb 238 21 genomes genome NNS cord-023726-2fduzqyb 238 22 and and CC cord-023726-2fduzqyb 238 23 complicated complicated JJ cord-023726-2fduzqyb 238 24 virus virus NN cord-023726-2fduzqyb 238 25 structures structure NNS cord-023726-2fduzqyb 238 26 . . . cord-023726-2fduzqyb 239 1 The the DT cord-023726-2fduzqyb 239 2 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 239 3 of of IN cord-023726-2fduzqyb 239 4 herpesviruses herpesviruses NNP cord-023726-2fduzqyb 239 5 are be VBP cord-023726-2fduzqyb 239 6 regular regular JJ cord-023726-2fduzqyb 239 7 icosahedrons icosahedron NNS cord-023726-2fduzqyb 239 8 but but CC cord-023726-2fduzqyb 239 9 those those DT cord-023726-2fduzqyb 239 10 of of IN cord-023726-2fduzqyb 239 11 poxviruses poxvirus NNS cord-023726-2fduzqyb 239 12 are be VBP cord-023726-2fduzqyb 239 13 complicated complicated JJ cord-023726-2fduzqyb 239 14 structures structure NNS cord-023726-2fduzqyb 239 15 containing contain VBG cord-023726-2fduzqyb 239 16 a a DT cord-023726-2fduzqyb 239 17 core core NN cord-023726-2fduzqyb 239 18 and and CC cord-023726-2fduzqyb 239 19 associated associated JJ cord-023726-2fduzqyb 239 20 lateral lateral JJ cord-023726-2fduzqyb 239 21 bodies body NNS cord-023726-2fduzqyb 239 22 . . . cord-023726-2fduzqyb 240 1 The the DT cord-023726-2fduzqyb 240 2 external external JJ cord-023726-2fduzqyb 240 3 proteins protein NNS cord-023726-2fduzqyb 240 4 of of IN cord-023726-2fduzqyb 240 5 enveloped envelop VBN cord-023726-2fduzqyb 240 6 virions virion NNS cord-023726-2fduzqyb 240 7 are be VBP cord-023726-2fduzqyb 240 8 virusencoded virusencode VBN cord-023726-2fduzqyb 240 9 proteins protein NNS cord-023726-2fduzqyb 240 10 that that WDT cord-023726-2fduzqyb 240 11 are be VBP cord-023726-2fduzqyb 240 12 anchored anchor VBN cord-023726-2fduzqyb 240 13 in in IN cord-023726-2fduzqyb 240 14 the the DT cord-023726-2fduzqyb 240 15 lipid lipid NN cord-023726-2fduzqyb 240 16 bilayer bilayer NN cord-023726-2fduzqyb 240 17 of of IN cord-023726-2fduzqyb 240 18 the the DT cord-023726-2fduzqyb 240 19 virus virus NN cord-023726-2fduzqyb 240 20 or or CC cord-023726-2fduzqyb 240 21 whose whose WP$ cord-023726-2fduzqyb 240 22 precursors precursor NNS cord-023726-2fduzqyb 240 23 are be VBP cord-023726-2fduzqyb 240 24 anchored anchor VBN cord-023726-2fduzqyb 240 25 in in IN cord-023726-2fduzqyb 240 26 the the DT cord-023726-2fduzqyb 240 27 lipid lipid NN cord-023726-2fduzqyb 240 28 bilayer bilayer NN cord-023726-2fduzqyb 240 29 . . . cord-023726-2fduzqyb 241 1 In in IN cord-023726-2fduzqyb 241 2 the the DT cord-023726-2fduzqyb 241 3 vast vast JJ cord-023726-2fduzqyb 241 4 majority majority NN cord-023726-2fduzqyb 241 5 of of IN cord-023726-2fduzqyb 241 6 cases case NNS cord-023726-2fduzqyb 241 7 these these DT cord-023726-2fduzqyb 241 8 proteins protein NNS cord-023726-2fduzqyb 241 9 are be VBP cord-023726-2fduzqyb 241 10 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 241 11 , , , cord-023726-2fduzqyb 241 12 although although IN cord-023726-2fduzqyb 241 13 examples example NNS cord-023726-2fduzqyb 241 14 are be VBP cord-023726-2fduzqyb 241 15 known know VBN cord-023726-2fduzqyb 241 16 that that WDT cord-023726-2fduzqyb 241 17 do do VBP cord-023726-2fduzqyb 241 18 not not RB cord-023726-2fduzqyb 241 19 contain contain VB cord-023726-2fduzqyb 241 20 bound bind VBN cord-023726-2fduzqyb 241 21 carbohydrate carbohydrate NN cord-023726-2fduzqyb 241 22 . . . cord-023726-2fduzqyb 242 1 These these DT cord-023726-2fduzqyb 242 2 proteins protein NNS cord-023726-2fduzqyb 242 3 are be VBP cord-023726-2fduzqyb 242 4 translated translate VBN cord-023726-2fduzqyb 242 5 from from IN cord-023726-2fduzqyb 242 6 viral viral JJ cord-023726-2fduzqyb 242 7 mRNAs mrnas CD cord-023726-2fduzqyb 242 8 and and CC cord-023726-2fduzqyb 242 9 transported transport VBN cord-023726-2fduzqyb 242 10 by by IN cord-023726-2fduzqyb 242 11 the the DT cord-023726-2fduzqyb 242 12 usual usual JJ cord-023726-2fduzqyb 242 13 cellular cellular JJ cord-023726-2fduzqyb 242 14 processes process NNS cord-023726-2fduzqyb 242 15 to to TO cord-023726-2fduzqyb 242 16 reach reach VB cord-023726-2fduzqyb 242 17 the the DT cord-023726-2fduzqyb 242 18 membrane membrane NN cord-023726-2fduzqyb 242 19 at at IN cord-023726-2fduzqyb 242 20 which which WDT cord-023726-2fduzqyb 242 21 budding budding NN cord-023726-2fduzqyb 242 22 will will MD cord-023726-2fduzqyb 242 23 occur occur VB cord-023726-2fduzqyb 242 24 . . . cord-023726-2fduzqyb 243 1 When when WRB cord-023726-2fduzqyb 243 2 budding bud VBG cord-023726-2fduzqyb 243 3 is be VBZ cord-023726-2fduzqyb 243 4 at at IN cord-023726-2fduzqyb 243 5 the the DT cord-023726-2fduzqyb 243 6 cell cell NN cord-023726-2fduzqyb 243 7 plasma plasma NN cord-023726-2fduzqyb 243 8 membrane membrane NN cord-023726-2fduzqyb 243 9 , , , cord-023726-2fduzqyb 243 10 the the DT cord-023726-2fduzqyb 243 11 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 243 12 are be VBP cord-023726-2fduzqyb 243 13 transported transport VBN cord-023726-2fduzqyb 243 14 via via IN cord-023726-2fduzqyb 243 15 the the DT cord-023726-2fduzqyb 243 16 Golgi Golgi NNP cord-023726-2fduzqyb 243 17 apparatus apparatus NN cord-023726-2fduzqyb 243 18 to to IN cord-023726-2fduzqyb 243 19 the the DT cord-023726-2fduzqyb 243 20 cell cell NN cord-023726-2fduzqyb 243 21 surface surface NN cord-023726-2fduzqyb 243 22 . . . cord-023726-2fduzqyb 244 1 Some some DT cord-023726-2fduzqyb 244 2 enveloped envelop VBN cord-023726-2fduzqyb 244 3 viruses virus NNS cord-023726-2fduzqyb 244 4 mature mature VBP cord-023726-2fduzqyb 244 5 at at IN cord-023726-2fduzqyb 244 6 intracellular intracellular JJ cord-023726-2fduzqyb 244 7 membranes membrane NNS cord-023726-2fduzqyb 244 8 , , , cord-023726-2fduzqyb 244 9 and and CC cord-023726-2fduzqyb 244 10 in in IN cord-023726-2fduzqyb 244 11 these these DT cord-023726-2fduzqyb 244 12 cases case NNS cord-023726-2fduzqyb 244 13 the the DT cord-023726-2fduzqyb 244 14 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 244 15 are be VBP cord-023726-2fduzqyb 244 16 directed direct VBN cord-023726-2fduzqyb 244 17 to to IN cord-023726-2fduzqyb 244 18 the the DT cord-023726-2fduzqyb 244 19 appropriate appropriate JJ cord-023726-2fduzqyb 244 20 place place NN cord-023726-2fduzqyb 244 21 in in IN cord-023726-2fduzqyb 244 22 the the DT cord-023726-2fduzqyb 244 23 cell cell NN cord-023726-2fduzqyb 244 24 . . . cord-023726-2fduzqyb 245 1 Both both DT cord-023726-2fduzqyb 245 2 Type type NN cord-023726-2fduzqyb 245 3 I -PRON- PRP cord-023726-2fduzqyb 245 4 integral integral JJ cord-023726-2fduzqyb 245 5 membrane membrane NN cord-023726-2fduzqyb 245 6 proteins protein NNS cord-023726-2fduzqyb 245 7 , , , cord-023726-2fduzqyb 245 8 in in IN cord-023726-2fduzqyb 245 9 which which WDT cord-023726-2fduzqyb 245 10 the the DT cord-023726-2fduzqyb 245 11 N n CD cord-023726-2fduzqyb 245 12 terminus terminus NN cord-023726-2fduzqyb 245 13 of of IN cord-023726-2fduzqyb 245 14 the the DT cord-023726-2fduzqyb 245 15 protein protein NN cord-023726-2fduzqyb 245 16 is be VBZ cord-023726-2fduzqyb 245 17 outside outside IN cord-023726-2fduzqyb 245 18 the the DT cord-023726-2fduzqyb 245 19 lipid lipid NN cord-023726-2fduzqyb 245 20 bilayer bilayer NN cord-023726-2fduzqyb 245 21 and and CC cord-023726-2fduzqyb 245 22 the the DT cord-023726-2fduzqyb 245 23 C C NNP cord-023726-2fduzqyb 245 24 terminus terminus NN cord-023726-2fduzqyb 245 25 is be VBZ cord-023726-2fduzqyb 245 26 inside inside IN cord-023726-2fduzqyb 245 27 the the DT cord-023726-2fduzqyb 245 28 bilayer bilayer NN cord-023726-2fduzqyb 245 29 , , , cord-023726-2fduzqyb 245 30 and and CC cord-023726-2fduzqyb 245 31 Type Type NNP cord-023726-2fduzqyb 245 32 II II NNP cord-023726-2fduzqyb 245 33 integral integral JJ cord-023726-2fduzqyb 245 34 membrane membrane NN cord-023726-2fduzqyb 245 35 proteins protein NNS cord-023726-2fduzqyb 245 36 , , , cord-023726-2fduzqyb 245 37 which which WDT cord-023726-2fduzqyb 245 38 have have VBP cord-023726-2fduzqyb 245 39 the the DT cord-023726-2fduzqyb 245 40 inverse inverse JJ cord-023726-2fduzqyb 245 41 orientation orientation NN cord-023726-2fduzqyb 245 42 with with IN cord-023726-2fduzqyb 245 43 the the DT cord-023726-2fduzqyb 245 44 C C NNP cord-023726-2fduzqyb 245 45 terminus terminus NN cord-023726-2fduzqyb 245 46 outside outside RB cord-023726-2fduzqyb 245 47 , , , cord-023726-2fduzqyb 245 48 are be VBP cord-023726-2fduzqyb 245 49 known know VBN cord-023726-2fduzqyb 245 50 for for IN cord-023726-2fduzqyb 245 51 different different JJ cord-023726-2fduzqyb 245 52 viruses virus NNS cord-023726-2fduzqyb 245 53 . . . cord-023726-2fduzqyb 246 1 Many many JJ cord-023726-2fduzqyb 246 2 viral viral JJ cord-023726-2fduzqyb 246 3 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 246 4 are be VBP cord-023726-2fduzqyb 246 5 produced produce VBN cord-023726-2fduzqyb 246 6 as as IN cord-023726-2fduzqyb 246 7 precursor precursor NN cord-023726-2fduzqyb 246 8 molecules molecule NNS cord-023726-2fduzqyb 246 9 that that WDT cord-023726-2fduzqyb 246 10 are be VBP cord-023726-2fduzqyb 246 11 cleaved cleave VBN cord-023726-2fduzqyb 246 12 by by IN cord-023726-2fduzqyb 246 13 cellular cellular JJ cord-023726-2fduzqyb 246 14 proteases protease NNS cord-023726-2fduzqyb 246 15 during during IN cord-023726-2fduzqyb 246 16 the the DT cord-023726-2fduzqyb 246 17 maturation maturation NN cord-023726-2fduzqyb 246 18 process process NN cord-023726-2fduzqyb 246 19 . . . cord-023726-2fduzqyb 247 1 Following follow VBG cord-023726-2fduzqyb 247 2 synthesis synthesis NN cord-023726-2fduzqyb 247 3 of of IN cord-023726-2fduzqyb 247 4 viral viral JJ cord-023726-2fduzqyb 247 5 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 247 6 , , , cord-023726-2fduzqyb 247 7 during during IN cord-023726-2fduzqyb 247 8 which which WDT cord-023726-2fduzqyb 247 9 they -PRON- PRP cord-023726-2fduzqyb 247 10 are be VBP cord-023726-2fduzqyb 247 11 transported transport VBN cord-023726-2fduzqyb 247 12 into into IN cord-023726-2fduzqyb 247 13 the the DT cord-023726-2fduzqyb 247 14 lumen lumen NN cord-023726-2fduzqyb 247 15 of of IN cord-023726-2fduzqyb 247 16 the the DT cord-023726-2fduzqyb 247 17 endoplasmic endoplasmic NN cord-023726-2fduzqyb 247 18 reticulum reticulum NN cord-023726-2fduzqyb 247 19 ( ( -LRB- cord-023726-2fduzqyb 247 20 ER ER NNP cord-023726-2fduzqyb 247 21 ) ) -RRB- cord-023726-2fduzqyb 247 22 in in IN cord-023726-2fduzqyb 247 23 an an DT cord-023726-2fduzqyb 247 24 unfolded unfolded JJ cord-023726-2fduzqyb 247 25 state state NN cord-023726-2fduzqyb 247 26 , , , cord-023726-2fduzqyb 247 27 they -PRON- PRP cord-023726-2fduzqyb 247 28 must must MD cord-023726-2fduzqyb 247 29 fold fold VB cord-023726-2fduzqyb 247 30 to to TO cord-023726-2fduzqyb 247 31 assume assume VB cord-023726-2fduzqyb 247 32 their -PRON- PRP$ cord-023726-2fduzqyb 247 33 proper proper JJ cord-023726-2fduzqyb 247 34 conformation conformation NN cord-023726-2fduzqyb 247 35 , , , cord-023726-2fduzqyb 247 36 and and CC cord-023726-2fduzqyb 247 37 assume assume VBP cord-023726-2fduzqyb 247 38 their -PRON- PRP$ cord-023726-2fduzqyb 247 39 proper proper JJ cord-023726-2fduzqyb 247 40 oxidation oxidation NN cord-023726-2fduzqyb 247 41 state state NN cord-023726-2fduzqyb 247 42 by by IN cord-023726-2fduzqyb 247 43 formation formation NN cord-023726-2fduzqyb 247 44 of of IN cord-023726-2fduzqyb 247 45 the the DT cord-023726-2fduzqyb 247 46 correct correct JJ cord-023726-2fduzqyb 247 47 disulfide disulfide NN cord-023726-2fduzqyb 247 48 bonds bond NNS cord-023726-2fduzqyb 247 49 . . . cord-023726-2fduzqyb 248 1 This this DT cord-023726-2fduzqyb 248 2 process process NN cord-023726-2fduzqyb 248 3 often often RB cord-023726-2fduzqyb 248 4 occurs occur VBZ cord-023726-2fduzqyb 248 5 very very RB cord-023726-2fduzqyb 248 6 quickly quickly RB cord-023726-2fduzqyb 248 7 , , , cord-023726-2fduzqyb 248 8 but but CC cord-023726-2fduzqyb 248 9 for for IN cord-023726-2fduzqyb 248 10 some some DT cord-023726-2fduzqyb 248 11 viral viral JJ cord-023726-2fduzqyb 248 12 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 248 13 it -PRON- PRP cord-023726-2fduzqyb 248 14 can can MD cord-023726-2fduzqyb 248 15 take take VB cord-023726-2fduzqyb 248 16 hours hour NNS cord-023726-2fduzqyb 248 17 . . . cord-023726-2fduzqyb 249 1 Folding folding NN cord-023726-2fduzqyb 249 2 is be VBZ cord-023726-2fduzqyb 249 3 often often RB cord-023726-2fduzqyb 249 4 assisted assist VBN cord-023726-2fduzqyb 249 5 by by IN cord-023726-2fduzqyb 249 6 chaperonins chaperonin NNS cord-023726-2fduzqyb 249 7 present present JJ cord-023726-2fduzqyb 249 8 in in IN cord-023726-2fduzqyb 249 9 the the DT cord-023726-2fduzqyb 249 10 endoplasmic endoplasmic NN cord-023726-2fduzqyb 249 11 reticulum reticulum NN cord-023726-2fduzqyb 249 12 . . . cord-023726-2fduzqyb 250 1 It -PRON- PRP cord-023726-2fduzqyb 250 2 is be VBZ cord-023726-2fduzqyb 250 3 believed believe VBN cord-023726-2fduzqyb 250 4 that that IN cord-023726-2fduzqyb 250 5 at at RB cord-023726-2fduzqyb 250 6 least least RBS cord-023726-2fduzqyb 250 7 one one CD cord-023726-2fduzqyb 250 8 function function NN cord-023726-2fduzqyb 250 9 of of IN cord-023726-2fduzqyb 250 10 the the DT cord-023726-2fduzqyb 250 11 carbohydrate carbohydrate NN cord-023726-2fduzqyb 250 12 chains chain NNS cord-023726-2fduzqyb 250 13 attached attach VBN cord-023726-2fduzqyb 250 14 to to IN cord-023726-2fduzqyb 250 15 the the DT cord-023726-2fduzqyb 250 16 protein protein NN cord-023726-2fduzqyb 250 17 is be VBZ cord-023726-2fduzqyb 250 18 to to TO cord-023726-2fduzqyb 250 19 increase increase VB cord-023726-2fduzqyb 250 20 the the DT cord-023726-2fduzqyb 250 21 solubility solubility NN cord-023726-2fduzqyb 250 22 of of IN cord-023726-2fduzqyb 250 23 the the DT cord-023726-2fduzqyb 250 24 unfolded unfolded JJ cord-023726-2fduzqyb 250 25 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 250 26 in in IN cord-023726-2fduzqyb 250 27 the the DT cord-023726-2fduzqyb 250 28 lumen lumen NN cord-023726-2fduzqyb 250 29 of of IN cord-023726-2fduzqyb 250 30 the the DT cord-023726-2fduzqyb 250 31 ER ER NNP cord-023726-2fduzqyb 250 32 so so IN cord-023726-2fduzqyb 250 33 that that IN cord-023726-2fduzqyb 250 34 they -PRON- PRP cord-023726-2fduzqyb 250 35 do do VBP cord-023726-2fduzqyb 250 36 not not RB cord-023726-2fduzqyb 250 37 aggregate aggregate VB cord-023726-2fduzqyb 250 38 prior prior RB cord-023726-2fduzqyb 250 39 to to IN cord-023726-2fduzqyb 250 40 folding folding NN cord-023726-2fduzqyb 250 41 . . . cord-023726-2fduzqyb 251 1 During during IN cord-023726-2fduzqyb 251 2 folding fold VBG cord-023726-2fduzqyb 251 3 , , , cord-023726-2fduzqyb 251 4 the the DT cord-023726-2fduzqyb 251 5 solubility solubility NN cord-023726-2fduzqyb 251 6 of of IN cord-023726-2fduzqyb 251 7 the the DT cord-023726-2fduzqyb 251 8 proteins protein NNS cord-023726-2fduzqyb 251 9 is be VBZ cord-023726-2fduzqyb 251 10 increased increase VBN cord-023726-2fduzqyb 251 11 by by IN cord-023726-2fduzqyb 251 12 hiding hide VBG cord-023726-2fduzqyb 251 13 hydrophobic hydrophobic JJ cord-023726-2fduzqyb 251 14 domains domain NNS cord-023726-2fduzqyb 251 15 within within IN cord-023726-2fduzqyb 251 16 the the DT cord-023726-2fduzqyb 251 17 interior interior NN cord-023726-2fduzqyb 251 18 of of IN cord-023726-2fduzqyb 251 19 the the DT cord-023726-2fduzqyb 251 20 protein protein NN cord-023726-2fduzqyb 251 21 and and CC cord-023726-2fduzqyb 251 22 leaving leave VBG cord-023726-2fduzqyb 251 23 hydrophilic hydrophilic JJ cord-023726-2fduzqyb 251 24 domains domain NNS cord-023726-2fduzqyb 251 25 at at IN cord-023726-2fduzqyb 251 26 the the DT cord-023726-2fduzqyb 251 27 surface surface NN cord-023726-2fduzqyb 251 28 . . . cord-023726-2fduzqyb 252 1 The the DT cord-023726-2fduzqyb 252 2 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 252 3 possess possess VBP cord-023726-2fduzqyb 252 4 a a DT cord-023726-2fduzqyb 252 5 number number NN cord-023726-2fduzqyb 252 6 of of IN cord-023726-2fduzqyb 252 7 important important JJ cord-023726-2fduzqyb 252 8 functions function NNS cord-023726-2fduzqyb 252 9 in in IN cord-023726-2fduzqyb 252 10 addition addition NN cord-023726-2fduzqyb 252 11 to to IN cord-023726-2fduzqyb 252 12 their -PRON- PRP$ cord-023726-2fduzqyb 252 13 structural structural JJ cord-023726-2fduzqyb 252 14 functions function NNS cord-023726-2fduzqyb 252 15 . . . cord-023726-2fduzqyb 253 1 They -PRON- PRP cord-023726-2fduzqyb 253 2 carry carry VBP cord-023726-2fduzqyb 253 3 the the DT cord-023726-2fduzqyb 253 4 attachment attachment NN cord-023726-2fduzqyb 253 5 domains domain NNS cord-023726-2fduzqyb 253 6 by by IN cord-023726-2fduzqyb 253 7 which which WDT cord-023726-2fduzqyb 253 8 the the DT cord-023726-2fduzqyb 253 9 virus virus NN cord-023726-2fduzqyb 253 10 binds bind VBZ cord-023726-2fduzqyb 253 11 to to IN cord-023726-2fduzqyb 253 12 a a DT cord-023726-2fduzqyb 253 13 susceptible susceptible JJ cord-023726-2fduzqyb 253 14 cell cell NN cord-023726-2fduzqyb 253 15 . . . cord-023726-2fduzqyb 254 1 This this DT cord-023726-2fduzqyb 254 2 activity activity NN cord-023726-2fduzqyb 254 3 is be VBZ cord-023726-2fduzqyb 254 4 thought think VBN cord-023726-2fduzqyb 254 5 to to TO cord-023726-2fduzqyb 254 6 be be VB cord-023726-2fduzqyb 254 7 related relate VBN cord-023726-2fduzqyb 254 8 to to IN cord-023726-2fduzqyb 254 9 the the DT cord-023726-2fduzqyb 254 10 ability ability NN cord-023726-2fduzqyb 254 11 of of IN cord-023726-2fduzqyb 254 12 many many JJ cord-023726-2fduzqyb 254 13 viruses virus NNS cord-023726-2fduzqyb 254 14 , , , cord-023726-2fduzqyb 254 15 nonenveloped nonenvelope VBN cord-023726-2fduzqyb 254 16 as as RB cord-023726-2fduzqyb 254 17 well well RB cord-023726-2fduzqyb 254 18 as as IN cord-023726-2fduzqyb 254 19 enveloped envelop VBN cord-023726-2fduzqyb 254 20 , , , cord-023726-2fduzqyb 254 21 to to TO cord-023726-2fduzqyb 254 22 bind bind VB cord-023726-2fduzqyb 254 23 to to IN cord-023726-2fduzqyb 254 24 and and CC cord-023726-2fduzqyb 254 25 agglutinate agglutinate VB cord-023726-2fduzqyb 254 26 red red JJ cord-023726-2fduzqyb 254 27 blood blood NN cord-023726-2fduzqyb 254 28 cells cell NNS cord-023726-2fduzqyb 254 29 , , , cord-023726-2fduzqyb 254 30 a a DT cord-023726-2fduzqyb 254 31 process process NN cord-023726-2fduzqyb 254 32 called call VBN cord-023726-2fduzqyb 254 33 hemagglutination hemagglutination NN cord-023726-2fduzqyb 254 34 . . . cord-023726-2fduzqyb 255 1 The the DT cord-023726-2fduzqyb 255 2 protein protein NN cord-023726-2fduzqyb 255 3 possessing possess VBG cord-023726-2fduzqyb 255 4 hemagglutinating hemagglutinate VBG cord-023726-2fduzqyb 255 5 activity activity NN cord-023726-2fduzqyb 255 6 is be VBZ cord-023726-2fduzqyb 255 7 often often RB cord-023726-2fduzqyb 255 8 called call VBN cord-023726-2fduzqyb 255 9 the the DT cord-023726-2fduzqyb 255 10 hemagglutinin hemagglutinin NN cord-023726-2fduzqyb 255 11 or or CC cord-023726-2fduzqyb 255 12 HA HA NNP cord-023726-2fduzqyb 255 13 . . . cord-023726-2fduzqyb 256 1 The the DT cord-023726-2fduzqyb 256 2 viral viral JJ cord-023726-2fduzqyb 256 3 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 256 4 also also RB cord-023726-2fduzqyb 256 5 possess possess VBP cord-023726-2fduzqyb 256 6 a a DT cord-023726-2fduzqyb 256 7 fusion fusion NN cord-023726-2fduzqyb 256 8 activity activity NN cord-023726-2fduzqyb 256 9 that that WDT cord-023726-2fduzqyb 256 10 promotes promote VBZ cord-023726-2fduzqyb 256 11 the the DT cord-023726-2fduzqyb 256 12 fusion fusion NN cord-023726-2fduzqyb 256 13 of of IN cord-023726-2fduzqyb 256 14 the the DT cord-023726-2fduzqyb 256 15 membrane membrane NN cord-023726-2fduzqyb 256 16 of of IN cord-023726-2fduzqyb 256 17 the the DT cord-023726-2fduzqyb 256 18 virus virus NN cord-023726-2fduzqyb 256 19 with with IN cord-023726-2fduzqyb 256 20 a a DT cord-023726-2fduzqyb 256 21 membrane membrane NN cord-023726-2fduzqyb 256 22 of of IN cord-023726-2fduzqyb 256 23 the the DT cord-023726-2fduzqyb 256 24 cell cell NN cord-023726-2fduzqyb 256 25 . . . cord-023726-2fduzqyb 257 1 The the DT cord-023726-2fduzqyb 257 2 protein protein NN cord-023726-2fduzqyb 257 3 possessing possess VBG cord-023726-2fduzqyb 257 4 this this DT cord-023726-2fduzqyb 257 5 activity activity NN cord-023726-2fduzqyb 257 6 is be VBZ cord-023726-2fduzqyb 257 7 sometimes sometimes RB cord-023726-2fduzqyb 257 8 called call VBN cord-023726-2fduzqyb 257 9 the the DT cord-023726-2fduzqyb 257 10 fusion fusion NN cord-023726-2fduzqyb 257 11 protein protein NN cord-023726-2fduzqyb 257 12 , , , cord-023726-2fduzqyb 257 13 or or CC cord-023726-2fduzqyb 257 14 F. f. NN cord-023726-2fduzqyb 258 1 The the DT cord-023726-2fduzqyb 258 2 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 258 3 , , , cord-023726-2fduzqyb 258 4 being be VBG cord-023726-2fduzqyb 258 5 external external JJ cord-023726-2fduzqyb 258 6 on on IN cord-023726-2fduzqyb 258 7 the the DT cord-023726-2fduzqyb 258 8 virus virus NN cord-023726-2fduzqyb 258 9 , , , cord-023726-2fduzqyb 258 10 are be VBP cord-023726-2fduzqyb 258 11 also also RB cord-023726-2fduzqyb 258 12 primary primary JJ cord-023726-2fduzqyb 258 13 targets target NNS cord-023726-2fduzqyb 258 14 of of IN cord-023726-2fduzqyb 258 15 the the DT cord-023726-2fduzqyb 258 16 humoral humoral JJ cord-023726-2fduzqyb 258 17 immune immune JJ cord-023726-2fduzqyb 258 18 system system NN cord-023726-2fduzqyb 258 19 , , , cord-023726-2fduzqyb 258 20 in in IN cord-023726-2fduzqyb 258 21 which which WDT cord-023726-2fduzqyb 258 22 circulating circulate VBG cord-023726-2fduzqyb 258 23 antibodies antibody NNS cord-023726-2fduzqyb 258 24 are be VBP cord-023726-2fduzqyb 258 25 directed direct VBN cord-023726-2fduzqyb 258 26 against against IN cord-023726-2fduzqyb 258 27 viruses virus NNS cord-023726-2fduzqyb 258 28 ; ; : cord-023726-2fduzqyb 258 29 many many JJ cord-023726-2fduzqyb 258 30 of of IN cord-023726-2fduzqyb 258 31 these these DT cord-023726-2fduzqyb 258 32 are be VBP cord-023726-2fduzqyb 258 33 neutralizing neutralize VBG cord-023726-2fduzqyb 258 34 antibodies antibody NNS cord-023726-2fduzqyb 258 35 that that WDT cord-023726-2fduzqyb 258 36 inactivate inactivate VBP cord-023726-2fduzqyb 258 37 the the DT cord-023726-2fduzqyb 258 38 virus virus NN cord-023726-2fduzqyb 258 39 . . . cord-023726-2fduzqyb 259 1 The the DT cord-023726-2fduzqyb 259 2 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 259 3 of of IN cord-023726-2fduzqyb 259 4 some some DT cord-023726-2fduzqyb 259 5 enveloped envelop VBN cord-023726-2fduzqyb 259 6 viruses virus NNS cord-023726-2fduzqyb 259 7 also also RB cord-023726-2fduzqyb 259 8 contain contain VBP cord-023726-2fduzqyb 259 9 enzymatic enzymatic JJ cord-023726-2fduzqyb 259 10 activities activity NNS cord-023726-2fduzqyb 259 11 . . . cord-023726-2fduzqyb 260 1 Many many JJ cord-023726-2fduzqyb 260 2 orthomyxoviruses orthomyxovirus NNS cord-023726-2fduzqyb 260 3 and and CC cord-023726-2fduzqyb 260 4 paramyxoviruses paramyxovirus NNS cord-023726-2fduzqyb 260 5 possess possess VBP cord-023726-2fduzqyb 260 6 a a DT cord-023726-2fduzqyb 260 7 neuraminidase neuraminidase NN cord-023726-2fduzqyb 260 8 that that WDT cord-023726-2fduzqyb 260 9 will will MD cord-023726-2fduzqyb 260 10 remove remove VB cord-023726-2fduzqyb 260 11 sialic sialic JJ cord-023726-2fduzqyb 260 12 acid acid NN cord-023726-2fduzqyb 260 13 from from IN cord-023726-2fduzqyb 260 14 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 260 15 . . . cord-023726-2fduzqyb 261 1 The the DT cord-023726-2fduzqyb 261 2 primary primary JJ cord-023726-2fduzqyb 261 3 receptor receptor NN cord-023726-2fduzqyb 261 4 for for IN cord-023726-2fduzqyb 261 5 these these DT cord-023726-2fduzqyb 261 6 viruses virus NNS cord-023726-2fduzqyb 261 7 is be VBZ cord-023726-2fduzqyb 261 8 sialic sialic JJ cord-023726-2fduzqyb 261 9 acid acid NN cord-023726-2fduzqyb 261 10 . . . cord-023726-2fduzqyb 262 1 The the DT cord-023726-2fduzqyb 262 2 neuraminidase neuraminidase NN cord-023726-2fduzqyb 262 3 may may MD cord-023726-2fduzqyb 262 4 allow allow VB cord-023726-2fduzqyb 262 5 the the DT cord-023726-2fduzqyb 262 6 virus virus NN cord-023726-2fduzqyb 262 7 to to TO cord-023726-2fduzqyb 262 8 penetrate penetrate VB cord-023726-2fduzqyb 262 9 through through IN cord-023726-2fduzqyb 262 10 mucus mucus NN cord-023726-2fduzqyb 262 11 to to TO cord-023726-2fduzqyb 262 12 reach reach VB cord-023726-2fduzqyb 262 13 a a DT cord-023726-2fduzqyb 262 14 susceptible susceptible JJ cord-023726-2fduzqyb 262 15 cell cell NN cord-023726-2fduzqyb 262 16 . . . cord-023726-2fduzqyb 263 1 It -PRON- PRP cord-023726-2fduzqyb 263 2 also also RB cord-023726-2fduzqyb 263 3 removes remove VBZ cord-023726-2fduzqyb 263 4 sialic sialic JJ cord-023726-2fduzqyb 263 5 acid acid NN cord-023726-2fduzqyb 263 6 from from IN cord-023726-2fduzqyb 263 7 the the DT cord-023726-2fduzqyb 263 8 viral viral JJ cord-023726-2fduzqyb 263 9 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 263 10 so so IN cord-023726-2fduzqyb 263 11 that that IN cord-023726-2fduzqyb 263 12 these these DT cord-023726-2fduzqyb 263 13 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 263 14 or or CC cord-023726-2fduzqyb 263 15 the the DT cord-023726-2fduzqyb 263 16 mature mature JJ cord-023726-2fduzqyb 263 17 virions virion NNS cord-023726-2fduzqyb 263 18 do do VBP cord-023726-2fduzqyb 263 19 not not RB cord-023726-2fduzqyb 263 20 aggregate aggregate VB cord-023726-2fduzqyb 263 21 , , , cord-023726-2fduzqyb 263 22 and and CC cord-023726-2fduzqyb 263 23 from from IN cord-023726-2fduzqyb 263 24 the the DT cord-023726-2fduzqyb 263 25 surface surface NN cord-023726-2fduzqyb 263 26 of of IN cord-023726-2fduzqyb 263 27 an an DT cord-023726-2fduzqyb 263 28 infected infected JJ cord-023726-2fduzqyb 263 29 cell cell NN cord-023726-2fduzqyb 263 30 , , , cord-023726-2fduzqyb 263 31 thereby thereby RB cord-023726-2fduzqyb 263 32 preventing prevent VBG cord-023726-2fduzqyb 263 33 released release VBN cord-023726-2fduzqyb 263 34 virions virion NNS cord-023726-2fduzqyb 263 35 from from IN cord-023726-2fduzqyb 263 36 binding bind VBG cord-023726-2fduzqyb 263 37 to to IN cord-023726-2fduzqyb 263 38 it -PRON- PRP cord-023726-2fduzqyb 263 39 . . . cord-023726-2fduzqyb 264 1 The the DT cord-023726-2fduzqyb 264 2 viral viral JJ cord-023726-2fduzqyb 264 3 protein protein NN cord-023726-2fduzqyb 264 4 possessing possess VBG cord-023726-2fduzqyb 264 5 neuraminidase neuraminidase NN cord-023726-2fduzqyb 264 6 activity activity NN cord-023726-2fduzqyb 264 7 may may MD cord-023726-2fduzqyb 264 8 be be VB cord-023726-2fduzqyb 264 9 called call VBN cord-023726-2fduzqyb 264 10 NA NA NNP cord-023726-2fduzqyb 264 11 , , , cord-023726-2fduzqyb 264 12 or or CC cord-023726-2fduzqyb 264 13 in in IN cord-023726-2fduzqyb 264 14 the the DT cord-023726-2fduzqyb 264 15 case case NN cord-023726-2fduzqyb 264 16 of of IN cord-023726-2fduzqyb 264 17 a a DT cord-023726-2fduzqyb 264 18 protein protein NN cord-023726-2fduzqyb 264 19 that that WDT cord-023726-2fduzqyb 264 20 is be VBZ cord-023726-2fduzqyb 264 21 both both CC cord-023726-2fduzqyb 264 22 a a DT cord-023726-2fduzqyb 264 23 neuraminidase neuraminidase NN cord-023726-2fduzqyb 264 24 and and CC cord-023726-2fduzqyb 264 25 hemagglutinin hemagglutinin NN cord-023726-2fduzqyb 264 26 , , , cord-023726-2fduzqyb 264 27 HN HN NNP cord-023726-2fduzqyb 264 28 . . . cord-023726-2fduzqyb 265 1 The the DT cord-023726-2fduzqyb 265 2 structure structure NN cord-023726-2fduzqyb 265 3 of of IN cord-023726-2fduzqyb 265 4 most most JJS cord-023726-2fduzqyb 265 5 enveloped envelop VBN cord-023726-2fduzqyb 265 6 viruses virus NNS cord-023726-2fduzqyb 265 7 is be VBZ cord-023726-2fduzqyb 265 8 not not RB cord-023726-2fduzqyb 265 9 as as RB cord-023726-2fduzqyb 265 10 rigorously rigorously RB cord-023726-2fduzqyb 265 11 constrained constrain VBN cord-023726-2fduzqyb 265 12 as as IN cord-023726-2fduzqyb 265 13 that that DT cord-023726-2fduzqyb 265 14 of of IN cord-023726-2fduzqyb 265 15 icosahedral icosahedral JJ cord-023726-2fduzqyb 265 16 virus virus NN cord-023726-2fduzqyb 265 17 particles particle NNS cord-023726-2fduzqyb 265 18 . . . cord-023726-2fduzqyb 266 1 The the DT cord-023726-2fduzqyb 266 2 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 266 3 are be VBP cord-023726-2fduzqyb 266 4 not not RB cord-023726-2fduzqyb 266 5 required require VBN cord-023726-2fduzqyb 266 6 to to TO cord-023726-2fduzqyb 266 7 form form VB cord-023726-2fduzqyb 266 8 an an DT cord-023726-2fduzqyb 266 9 impenetrable impenetrable JJ cord-023726-2fduzqyb 266 10 shell shell NN cord-023726-2fduzqyb 266 11 , , , cord-023726-2fduzqyb 266 12 which which WDT cord-023726-2fduzqyb 266 13 is be VBZ cord-023726-2fduzqyb 266 14 instead instead RB cord-023726-2fduzqyb 266 15 a a DT cord-023726-2fduzqyb 266 16 function function NN cord-023726-2fduzqyb 266 17 of of IN cord-023726-2fduzqyb 266 18 the the DT cord-023726-2fduzqyb 266 19 lipid lipid NN cord-023726-2fduzqyb 266 20 bilayer bilayer NN cord-023726-2fduzqyb 266 21 . . . cord-023726-2fduzqyb 267 1 They -PRON- PRP cord-023726-2fduzqyb 267 2 appear appear VBP cord-023726-2fduzqyb 267 3 to to TO cord-023726-2fduzqyb 267 4 tolerate tolerate VB cord-023726-2fduzqyb 267 5 mutations mutation NNS cord-023726-2fduzqyb 267 6 more more RBR cord-023726-2fduzqyb 267 7 readily readily RB cord-023726-2fduzqyb 267 8 than than IN cord-023726-2fduzqyb 267 9 do do VB cord-023726-2fduzqyb 267 10 proteins protein NNS cord-023726-2fduzqyb 267 11 that that WDT cord-023726-2fduzqyb 267 12 must must MD cord-023726-2fduzqyb 267 13 form form VB cord-023726-2fduzqyb 267 14 a a DT cord-023726-2fduzqyb 267 15 tight tight JJ cord-023726-2fduzqyb 267 16 icosahedral icosahedral JJ cord-023726-2fduzqyb 267 17 shell shell NN cord-023726-2fduzqyb 267 18 and and CC cord-023726-2fduzqyb 267 19 appear appear VBP cord-023726-2fduzqyb 267 20 to to TO cord-023726-2fduzqyb 267 21 evolve evolve VB cord-023726-2fduzqyb 267 22 rapidly rapidly RB cord-023726-2fduzqyb 267 23 in in IN cord-023726-2fduzqyb 267 24 response response NN cord-023726-2fduzqyb 267 25 to to IN cord-023726-2fduzqyb 267 26 immune immune JJ cord-023726-2fduzqyb 267 27 pressure pressure NN cord-023726-2fduzqyb 267 28 . . . cord-023726-2fduzqyb 268 1 However however RB cord-023726-2fduzqyb 268 2 , , , cord-023726-2fduzqyb 268 3 the the DT cord-023726-2fduzqyb 268 4 integrity integrity NN cord-023726-2fduzqyb 268 5 of of IN cord-023726-2fduzqyb 268 6 the the DT cord-023726-2fduzqyb 268 7 lipid lipid NN cord-023726-2fduzqyb 268 8 bilayer bilayer NN cord-023726-2fduzqyb 268 9 is be VBZ cord-023726-2fduzqyb 268 10 essential essential JJ cord-023726-2fduzqyb 268 11 for for IN cord-023726-2fduzqyb 268 12 virus virus NN cord-023726-2fduzqyb 268 13 infectivity infectivity NN cord-023726-2fduzqyb 268 14 , , , cord-023726-2fduzqyb 268 15 and and CC cord-023726-2fduzqyb 268 16 enveloped envelop VBN cord-023726-2fduzqyb 268 17 viruses virus NNS cord-023726-2fduzqyb 268 18 are be VBP cord-023726-2fduzqyb 268 19 very very RB cord-023726-2fduzqyb 268 20 sensitive sensitive JJ cord-023726-2fduzqyb 268 21 to to IN cord-023726-2fduzqyb 268 22 detergents detergent NNS cord-023726-2fduzqyb 268 23 . . . cord-023726-2fduzqyb 269 1 In in IN cord-023726-2fduzqyb 269 2 some some DT cord-023726-2fduzqyb 269 3 enveloped envelop VBN cord-023726-2fduzqyb 269 4 viruses virus NNS cord-023726-2fduzqyb 269 5 , , , cord-023726-2fduzqyb 269 6 there there EX cord-023726-2fduzqyb 269 7 is be VBZ cord-023726-2fduzqyb 269 8 a a DT cord-023726-2fduzqyb 269 9 structural structural JJ cord-023726-2fduzqyb 269 10 protein protein NN cord-023726-2fduzqyb 269 11 that that WDT cord-023726-2fduzqyb 269 12 underlies underlie VBZ cord-023726-2fduzqyb 269 13 the the DT cord-023726-2fduzqyb 269 14 lipid lipid NN cord-023726-2fduzqyb 269 15 envelope envelope NN cord-023726-2fduzqyb 269 16 but but CC cord-023726-2fduzqyb 269 17 which which WDT cord-023726-2fduzqyb 269 18 does do VBZ cord-023726-2fduzqyb 269 19 not not RB cord-023726-2fduzqyb 269 20 form form VB cord-023726-2fduzqyb 269 21 part part NN cord-023726-2fduzqyb 269 22 of of IN cord-023726-2fduzqyb 269 23 the the DT cord-023726-2fduzqyb 269 24 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 269 25 . . . cord-023726-2fduzqyb 270 1 Several several JJ cord-023726-2fduzqyb 270 2 families family NNS cord-023726-2fduzqyb 270 3 of of IN cord-023726-2fduzqyb 270 4 minus minus JJ cord-023726-2fduzqyb 270 5 - - HYPH cord-023726-2fduzqyb 270 6 strand strand NN cord-023726-2fduzqyb 270 7 RNA RNA NNP cord-023726-2fduzqyb 270 8 viruses virus NNS cord-023726-2fduzqyb 270 9 possess possess VBP cord-023726-2fduzqyb 270 10 such such PDT cord-023726-2fduzqyb 270 11 a a DT cord-023726-2fduzqyb 270 12 protein protein NN cord-023726-2fduzqyb 270 13 , , , cord-023726-2fduzqyb 270 14 called call VBD cord-023726-2fduzqyb 270 15 the the DT cord-023726-2fduzqyb 270 16 matrix matrix NN cord-023726-2fduzqyb 270 17 protein protein NN cord-023726-2fduzqyb 270 18 . . . cord-023726-2fduzqyb 271 1 This this DT cord-023726-2fduzqyb 271 2 protein protein NN cord-023726-2fduzqyb 271 3 may may MD cord-023726-2fduzqyb 271 4 serve serve VB cord-023726-2fduzqyb 271 5 as as IN cord-023726-2fduzqyb 271 6 an an DT cord-023726-2fduzqyb 271 7 adapter adapter NN cord-023726-2fduzqyb 271 8 between between IN cord-023726-2fduzqyb 271 9 the the DT cord-023726-2fduzqyb 271 10 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 271 11 and and CC cord-023726-2fduzqyb 271 12 the the DT cord-023726-2fduzqyb 271 13 envelope envelope NN cord-023726-2fduzqyb 271 14 . . . cord-023726-2fduzqyb 272 1 It -PRON- PRP cord-023726-2fduzqyb 272 2 may may MD cord-023726-2fduzqyb 272 3 also also RB cord-023726-2fduzqyb 272 4 have have VB cord-023726-2fduzqyb 272 5 regulatory regulatory JJ cord-023726-2fduzqyb 272 6 functions function NNS cord-023726-2fduzqyb 272 7 in in IN cord-023726-2fduzqyb 272 8 viral viral JJ cord-023726-2fduzqyb 272 9 RNA RNA NNP cord-023726-2fduzqyb 272 10 replication replication NN cord-023726-2fduzqyb 272 11 . . . cord-023726-2fduzqyb 273 1 The the DT cord-023726-2fduzqyb 273 2 herpesviruses herpesviruse NNS cord-023726-2fduzqyb 273 3 also also RB cord-023726-2fduzqyb 273 4 have have VBP cord-023726-2fduzqyb 273 5 proteins protein NNS cord-023726-2fduzqyb 273 6 underlying underlie VBG cord-023726-2fduzqyb 273 7 the the DT cord-023726-2fduzqyb 273 8 envelope envelope NN cord-023726-2fduzqyb 273 9 that that WDT cord-023726-2fduzqyb 273 10 form form VBP cord-023726-2fduzqyb 273 11 a a DT cord-023726-2fduzqyb 273 12 thick thick JJ cord-023726-2fduzqyb 273 13 layer layer NN cord-023726-2fduzqyb 273 14 called call VBN cord-023726-2fduzqyb 273 15 the the DT cord-023726-2fduzqyb 273 16 tegument tegument NN cord-023726-2fduzqyb 273 17 . . . cord-023726-2fduzqyb 274 1 The the DT cord-023726-2fduzqyb 274 2 thickness thickness NN cord-023726-2fduzqyb 274 3 of of IN cord-023726-2fduzqyb 274 4 the the DT cord-023726-2fduzqyb 274 5 tegument tegument NN cord-023726-2fduzqyb 274 6 is be VBZ cord-023726-2fduzqyb 274 7 not not RB cord-023726-2fduzqyb 274 8 uniform uniform JJ cord-023726-2fduzqyb 274 9 within within IN cord-023726-2fduzqyb 274 10 a a DT cord-023726-2fduzqyb 274 11 virion virion NN cord-023726-2fduzqyb 274 12 , , , cord-023726-2fduzqyb 274 13 giving give VBG cord-023726-2fduzqyb 274 14 rise rise NN cord-023726-2fduzqyb 274 15 to to IN cord-023726-2fduzqyb 274 16 some some DT cord-023726-2fduzqyb 274 17 irregularity irregularity NN cord-023726-2fduzqyb 274 18 in in IN cord-023726-2fduzqyb 274 19 its -PRON- PRP$ cord-023726-2fduzqyb 274 20 structure structure NN cord-023726-2fduzqyb 274 21 . . . cord-023726-2fduzqyb 275 1 The the DT cord-023726-2fduzqyb 275 2 tegument tegument NN cord-023726-2fduzqyb 275 3 proteins protein NNS cord-023726-2fduzqyb 275 4 perform perform VBP cord-023726-2fduzqyb 275 5 important important JJ cord-023726-2fduzqyb 275 6 functions function NNS cord-023726-2fduzqyb 275 7 early early RB cord-023726-2fduzqyb 275 8 after after IN cord-023726-2fduzqyb 275 9 infection infection NN cord-023726-2fduzqyb 275 10 of of IN cord-023726-2fduzqyb 275 11 a a DT cord-023726-2fduzqyb 275 12 cell cell NN cord-023726-2fduzqyb 275 13 by by IN cord-023726-2fduzqyb 275 14 a a DT cord-023726-2fduzqyb 275 15 herpesvirus herpesvirus NN cord-023726-2fduzqyb 275 16 ( ( -LRB- cord-023726-2fduzqyb 275 17 see see VB cord-023726-2fduzqyb 275 18 Chapter Chapter NNP cord-023726-2fduzqyb 275 19 7 7 CD cord-023726-2fduzqyb 275 20 ) ) -RRB- cord-023726-2fduzqyb 275 21 . . . cord-023726-2fduzqyb 276 1 The the DT cord-023726-2fduzqyb 276 2 alphaviruses alphavirus NNS cord-023726-2fduzqyb 276 3 , , , cord-023726-2fduzqyb 276 4 a a DT cord-023726-2fduzqyb 276 5 genus genus NN cord-023726-2fduzqyb 276 6 in in IN cord-023726-2fduzqyb 276 7 the the DT cord-023726-2fduzqyb 276 8 family family NN cord-023726-2fduzqyb 276 9 Togaviridae Togaviridae NNP cord-023726-2fduzqyb 276 10 , , , cord-023726-2fduzqyb 276 11 are be VBP cord-023726-2fduzqyb 276 12 exceptional exceptional JJ cord-023726-2fduzqyb 276 13 among among IN cord-023726-2fduzqyb 276 14 enveloped envelop VBN cord-023726-2fduzqyb 276 15 RNA RNA NNP cord-023726-2fduzqyb 276 16 viruses virus NNS cord-023726-2fduzqyb 276 17 in in IN cord-023726-2fduzqyb 276 18 the the DT cord-023726-2fduzqyb 276 19 regularity regularity NN cord-023726-2fduzqyb 276 20 of of IN cord-023726-2fduzqyb 276 21 their -PRON- PRP$ cord-023726-2fduzqyb 276 22 virions virion NNS cord-023726-2fduzqyb 276 23 , , , cord-023726-2fduzqyb 276 24 which which WDT cord-023726-2fduzqyb 276 25 are be VBP cord-023726-2fduzqyb 276 26 uniform uniform JJ cord-023726-2fduzqyb 276 27 icosahedral icosahedral JJ cord-023726-2fduzqyb 276 28 particles particle NNS cord-023726-2fduzqyb 276 29 . . . cord-023726-2fduzqyb 277 1 Virions Virions NNP cord-023726-2fduzqyb 277 2 of of IN cord-023726-2fduzqyb 277 3 two two CD cord-023726-2fduzqyb 277 4 alphaviruses alphavirus NNS cord-023726-2fduzqyb 277 5 have have VBP cord-023726-2fduzqyb 277 6 been be VBN cord-023726-2fduzqyb 277 7 crystallized crystallize VBN cord-023726-2fduzqyb 277 8 and and CC cord-023726-2fduzqyb 277 9 the the DT cord-023726-2fduzqyb 277 10 crystals crystal NNS cord-023726-2fduzqyb 277 11 are be VBP cord-023726-2fduzqyb 277 12 regular regular JJ cord-023726-2fduzqyb 277 13 enough enough RB cord-023726-2fduzqyb 277 14 to to TO cord-023726-2fduzqyb 277 15 diffract diffract VB cord-023726-2fduzqyb 277 16 to to IN cord-023726-2fduzqyb 277 17 30 30 CD cord-023726-2fduzqyb 277 18 - - HYPH cord-023726-2fduzqyb 277 19 40-Å 40-å CD cord-023726-2fduzqyb 277 20 resolution resolution NN cord-023726-2fduzqyb 277 21 . . . cord-023726-2fduzqyb 278 1 Higher high JJR cord-023726-2fduzqyb 278 2 resolution resolution NN cord-023726-2fduzqyb 278 3 has have VBZ cord-023726-2fduzqyb 278 4 been be VBN cord-023726-2fduzqyb 278 5 obtained obtain VBN cord-023726-2fduzqyb 278 6 from from IN cord-023726-2fduzqyb 278 7 cryoelectron cryoelectron NNP cord-023726-2fduzqyb 278 8 microscopy microscopy NNP cord-023726-2fduzqyb 278 9 , , , cord-023726-2fduzqyb 278 10 which which WDT cord-023726-2fduzqyb 278 11 has have VBZ cord-023726-2fduzqyb 278 12 been be VBN cord-023726-2fduzqyb 278 13 used use VBN cord-023726-2fduzqyb 278 14 to to TO cord-023726-2fduzqyb 278 15 determine determine VB cord-023726-2fduzqyb 278 16 the the DT cord-023726-2fduzqyb 278 17 structures structure NNS cord-023726-2fduzqyb 278 18 of of IN cord-023726-2fduzqyb 278 19 several several JJ cord-023726-2fduzqyb 278 20 alphaviruses alphavirus NNS cord-023726-2fduzqyb 278 21 to to IN cord-023726-2fduzqyb 278 22 7 7 CD cord-023726-2fduzqyb 278 23 - - SYM cord-023726-2fduzqyb 278 24 25 25 CD cord-023726-2fduzqyb 278 25 Å å NN cord-023726-2fduzqyb 278 26 ( ( -LRB- cord-023726-2fduzqyb 278 27 Fig fig NN cord-023726-2fduzqyb 278 28 . . . cord-023726-2fduzqyb 278 29 2.5 2.5 CD cord-023726-2fduzqyb 278 30 ) ) -RRB- cord-023726-2fduzqyb 278 31 . . . cord-023726-2fduzqyb 279 1 More more RBR cord-023726-2fduzqyb 279 2 detailed detailed JJ cord-023726-2fduzqyb 279 3 reconstructions reconstruction NNS cord-023726-2fduzqyb 279 4 of of IN cord-023726-2fduzqyb 279 5 Sindbis Sindbis NNP cord-023726-2fduzqyb 279 6 virus virus NN cord-023726-2fduzqyb 279 7 and and CC cord-023726-2fduzqyb 279 8 Ross Ross NNP cord-023726-2fduzqyb 279 9 River River NNP cord-023726-2fduzqyb 279 10 virus virus NN cord-023726-2fduzqyb 279 11 ( ( -LRB- cord-023726-2fduzqyb 279 12 RRV RRV NNP cord-023726-2fduzqyb 279 13 ) ) -RRB- cord-023726-2fduzqyb 279 14 have have VBP cord-023726-2fduzqyb 279 15 been be VBN cord-023726-2fduzqyb 279 16 derived derive VBN cord-023726-2fduzqyb 279 17 from from IN cord-023726-2fduzqyb 279 18 a a DT cord-023726-2fduzqyb 279 19 combination combination NN cord-023726-2fduzqyb 279 20 of of IN cord-023726-2fduzqyb 279 21 cryoelectron cryoelectron NN cord-023726-2fduzqyb 279 22 microscopy microscopy NNS cord-023726-2fduzqyb 279 23 of of IN cord-023726-2fduzqyb 279 24 the the DT cord-023726-2fduzqyb 279 25 intact intact JJ cord-023726-2fduzqyb 279 26 virion virion NN cord-023726-2fduzqyb 279 27 and and CC cord-023726-2fduzqyb 279 28 X x NN cord-023726-2fduzqyb 279 29 - - NN cord-023726-2fduzqyb 279 30 ray ray NN cord-023726-2fduzqyb 279 31 crystallography crystallography NN cord-023726-2fduzqyb 279 32 of of IN cord-023726-2fduzqyb 279 33 alphavirus alphavirus NNP cord-023726-2fduzqyb 279 34 structural structural JJ cord-023726-2fduzqyb 279 35 proteins protein NNS cord-023726-2fduzqyb 279 36 . . . cord-023726-2fduzqyb 280 1 A a DT cord-023726-2fduzqyb 280 2 cutaway cutaway NN cord-023726-2fduzqyb 280 3 view view NN cord-023726-2fduzqyb 280 4 of of IN cord-023726-2fduzqyb 280 5 RRV RRV NNP cord-023726-2fduzqyb 280 6 at at IN cord-023726-2fduzqyb 280 7 about about IN cord-023726-2fduzqyb 280 8 25-Å 25-å CD cord-023726-2fduzqyb 280 9 resolution resolution NN cord-023726-2fduzqyb 280 10 is be VBZ cord-023726-2fduzqyb 280 11 shown show VBN cord-023726-2fduzqyb 280 12 in in IN cord-023726-2fduzqyb 280 13 Fig Fig NNP cord-023726-2fduzqyb 280 14 . . . cord-023726-2fduzqyb 280 15 _SP cord-023726-2fduzqyb 281 1 2.14A 2.14A NNP cord-023726-2fduzqyb 281 2 . . . cord-023726-2fduzqyb 282 1 The the DT cord-023726-2fduzqyb 282 2 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 282 3 , , , cord-023726-2fduzqyb 282 4 shown show VBN cord-023726-2fduzqyb 282 5 in in IN cord-023726-2fduzqyb 282 6 red red JJ cord-023726-2fduzqyb 282 7 and and CC cord-023726-2fduzqyb 282 8 yellow yellow JJ cord-023726-2fduzqyb 282 9 , , , cord-023726-2fduzqyb 282 10 has have VBZ cord-023726-2fduzqyb 282 11 a a DT cord-023726-2fduzqyb 282 12 diameter diameter NN cord-023726-2fduzqyb 282 13 of of IN cord-023726-2fduzqyb 282 14 400 400 CD cord-023726-2fduzqyb 282 15 Å å NN cord-023726-2fduzqyb 282 16 , , , cord-023726-2fduzqyb 282 17 and and CC cord-023726-2fduzqyb 282 18 is be VBZ cord-023726-2fduzqyb 282 19 a a DT cord-023726-2fduzqyb 282 20 regular regular JJ cord-023726-2fduzqyb 282 21 icosahedron icosahedron NN cord-023726-2fduzqyb 282 22 with with IN cord-023726-2fduzqyb 282 23 T=4 T=4 NNP cord-023726-2fduzqyb 282 24 symmetry symmetry NN cord-023726-2fduzqyb 282 25 . . . cord-023726-2fduzqyb 283 1 It -PRON- PRP cord-023726-2fduzqyb 283 2 is be VBZ cord-023726-2fduzqyb 283 3 formed form VBN cord-023726-2fduzqyb 283 4 from from IN cord-023726-2fduzqyb 283 5 240 240 CD cord-023726-2fduzqyb 283 6 copies copy NNS cord-023726-2fduzqyb 283 7 of of IN cord-023726-2fduzqyb 283 8 a a DT cord-023726-2fduzqyb 283 9 single single JJ cord-023726-2fduzqyb 283 10 species specie NNS cord-023726-2fduzqyb 283 11 of of IN cord-023726-2fduzqyb 283 12 capsid capsid NN cord-023726-2fduzqyb 283 13 protein protein NN cord-023726-2fduzqyb 283 14 of of IN cord-023726-2fduzqyb 283 15 size size NN cord-023726-2fduzqyb 283 16 30 30 CD cord-023726-2fduzqyb 283 17 kDa kDa NNS cord-023726-2fduzqyb 283 18 . . . cord-023726-2fduzqyb 284 1 Note note VB cord-023726-2fduzqyb 284 2 the the DT cord-023726-2fduzqyb 284 3 fivefold fivefold NN cord-023726-2fduzqyb 284 4 and and CC cord-023726-2fduzqyb 284 5 sixfold sixfold NN cord-023726-2fduzqyb 284 6 coordinated coordinated JJ cord-023726-2fduzqyb 284 7 pedestals pedestal NNS cord-023726-2fduzqyb 284 8 in in IN cord-023726-2fduzqyb 284 9 yellow yellow JJ cord-023726-2fduzqyb 284 10 that that WDT cord-023726-2fduzqyb 284 11 rise rise VBP cord-023726-2fduzqyb 284 12 above above IN cord-023726-2fduzqyb 284 13 the the DT cord-023726-2fduzqyb 284 14 red red JJ cord-023726-2fduzqyb 284 15 background background NN cord-023726-2fduzqyb 284 16 of of IN cord-023726-2fduzqyb 284 17 RNA RNA NNP cord-023726-2fduzqyb 284 18 and and CC cord-023726-2fduzqyb 284 19 unstructured unstructured JJ cord-023726-2fduzqyb 284 20 parts part NNS cord-023726-2fduzqyb 284 21 of of IN cord-023726-2fduzqyb 284 22 the the DT cord-023726-2fduzqyb 284 23 protein protein NN cord-023726-2fduzqyb 284 24 . . . cord-023726-2fduzqyb 285 1 Each each DT cord-023726-2fduzqyb 285 2 of of IN cord-023726-2fduzqyb 285 3 these these DT cord-023726-2fduzqyb 285 4 pedestals pedestal NNS cord-023726-2fduzqyb 285 5 is be VBZ cord-023726-2fduzqyb 285 6 formed form VBN cord-023726-2fduzqyb 285 7 by by IN cord-023726-2fduzqyb 285 8 the the DT cord-023726-2fduzqyb 285 9 ordered order VBN cord-023726-2fduzqyb 285 10 domains domain NNS cord-023726-2fduzqyb 285 11 of of IN cord-023726-2fduzqyb 285 12 one one CD cord-023726-2fduzqyb 285 13 capsid capsid NN cord-023726-2fduzqyb 285 14 protein protein NN cord-023726-2fduzqyb 285 15 molecule molecule NN cord-023726-2fduzqyb 285 16 . . . cord-023726-2fduzqyb 286 1 The the DT cord-023726-2fduzqyb 286 2 lipid lipid NN cord-023726-2fduzqyb 286 3 bilayer bilayer NN cord-023726-2fduzqyb 286 4 is be VBZ cord-023726-2fduzqyb 286 5 shown show VBN cord-023726-2fduzqyb 286 6 in in IN cord-023726-2fduzqyb 286 7 green green JJ cord-023726-2fduzqyb 286 8 and and CC cord-023726-2fduzqyb 286 9 is be VBZ cord-023726-2fduzqyb 286 10 positioned position VBN cord-023726-2fduzqyb 286 11 between between IN cord-023726-2fduzqyb 286 12 the the DT cord-023726-2fduzqyb 286 13 capsid capsid NN cord-023726-2fduzqyb 286 14 and and CC cord-023726-2fduzqyb 286 15 the the DT cord-023726-2fduzqyb 286 16 external external JJ cord-023726-2fduzqyb 286 17 shell shell NN cord-023726-2fduzqyb 286 18 of of IN cord-023726-2fduzqyb 286 19 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 286 20 , , , cord-023726-2fduzqyb 286 21 shown show VBN cord-023726-2fduzqyb 286 22 in in IN cord-023726-2fduzqyb 286 23 blue blue JJ cord-023726-2fduzqyb 286 24 . . . cord-023726-2fduzqyb 287 1 The the DT cord-023726-2fduzqyb 287 2 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 287 3 are be VBP cord-023726-2fduzqyb 287 4 also also RB cord-023726-2fduzqyb 287 5 icosahedrally icosahedrally RB cord-023726-2fduzqyb 287 6 arranged arrange VBN cord-023726-2fduzqyb 287 7 with with IN cord-023726-2fduzqyb 287 8 T=4 T=4 NNP cord-023726-2fduzqyb 287 9 symmetry symmetry NN cord-023726-2fduzqyb 287 10 . . . cord-023726-2fduzqyb 288 1 The the DT cord-023726-2fduzqyb 288 2 complete complete JJ cord-023726-2fduzqyb 288 3 structure structure NN cord-023726-2fduzqyb 288 4 is be VBZ cord-023726-2fduzqyb 288 5 therefore therefore RB cord-023726-2fduzqyb 288 6 quite quite RB cord-023726-2fduzqyb 288 7 regular regular JJ cord-023726-2fduzqyb 288 8 and and CC cord-023726-2fduzqyb 288 9 the the DT cord-023726-2fduzqyb 288 10 virion virion NN cord-023726-2fduzqyb 288 11 has have VBZ cord-023726-2fduzqyb 288 12 been be VBN cord-023726-2fduzqyb 288 13 described describe VBN cord-023726-2fduzqyb 288 14 as as IN cord-023726-2fduzqyb 288 15 composed compose VBN cord-023726-2fduzqyb 288 16 of of IN cord-023726-2fduzqyb 288 17 two two CD cord-023726-2fduzqyb 288 18 interacting interact VBG cord-023726-2fduzqyb 288 19 protein protein NN cord-023726-2fduzqyb 288 20 shells shell NNS cord-023726-2fduzqyb 288 21 with with IN cord-023726-2fduzqyb 288 22 a a DT cord-023726-2fduzqyb 288 23 lipid lipid NN cord-023726-2fduzqyb 288 24 bilayer bilayer NN cord-023726-2fduzqyb 288 25 sandwiched sandwich VBN cord-023726-2fduzqyb 288 26 between between IN cord-023726-2fduzqyb 288 27 . . . cord-023726-2fduzqyb 289 1 The the DT cord-023726-2fduzqyb 289 2 structure structure NN cord-023726-2fduzqyb 289 3 of of IN cord-023726-2fduzqyb 289 4 the the DT cord-023726-2fduzqyb 289 5 ordered order VBN cord-023726-2fduzqyb 289 6 part part NN cord-023726-2fduzqyb 289 7 of of IN cord-023726-2fduzqyb 289 8 the the DT cord-023726-2fduzqyb 289 9 capsid capsid JJ cord-023726-2fduzqyb 289 10 protein protein NN cord-023726-2fduzqyb 289 11 of of IN cord-023726-2fduzqyb 289 12 Sindbis Sindbis NNP cord-023726-2fduzqyb 289 13 virus virus NN cord-023726-2fduzqyb 289 14 has have VBZ cord-023726-2fduzqyb 289 15 been be VBN cord-023726-2fduzqyb 289 16 solved solve VBN cord-023726-2fduzqyb 289 17 to to IN cord-023726-2fduzqyb 289 18 atomic atomic JJ cord-023726-2fduzqyb 289 19 resolution resolution NN cord-023726-2fduzqyb 289 20 by by IN cord-023726-2fduzqyb 289 21 conventional conventional JJ cord-023726-2fduzqyb 289 22 X x NN cord-023726-2fduzqyb 289 23 - - NN cord-023726-2fduzqyb 289 24 ray ray NN cord-023726-2fduzqyb 289 25 crystallography crystallography NN cord-023726-2fduzqyb 289 26 and and CC cord-023726-2fduzqyb 289 27 this this DT cord-023726-2fduzqyb 289 28 structure structure NN cord-023726-2fduzqyb 289 29 is be VBZ cord-023726-2fduzqyb 289 30 shown show VBN cord-023726-2fduzqyb 289 31 in in IN cord-023726-2fduzqyb 289 32 Fig Fig NNP cord-023726-2fduzqyb 289 33 . . . cord-023726-2fduzqyb 290 1 2 2 LS cord-023726-2fduzqyb 290 2 . . . cord-023726-2fduzqyb 291 1 14B. 14b. LS cord-023726-2fduzqyb 292 1 The the DT cord-023726-2fduzqyb 292 2 first first JJ cord-023726-2fduzqyb 292 3 113 113 CD cord-023726-2fduzqyb 292 4 residues residue NNS cord-023726-2fduzqyb 292 5 are be VBP cord-023726-2fduzqyb 292 6 disordered disordered JJ cord-023726-2fduzqyb 292 7 and and CC cord-023726-2fduzqyb 292 8 the the DT cord-023726-2fduzqyb 292 9 structure structure NN cord-023726-2fduzqyb 292 10 is be VBZ cord-023726-2fduzqyb 292 11 formed form VBN cord-023726-2fduzqyb 292 12 by by IN cord-023726-2fduzqyb 292 13 residues residue NNS cord-023726-2fduzqyb 292 14 114 114 CD cord-023726-2fduzqyb 292 15 - - SYM cord-023726-2fduzqyb 292 16 264 264 CD cord-023726-2fduzqyb 292 17 . . . cord-023726-2fduzqyb 293 1 This this DT cord-023726-2fduzqyb 293 2 ordered order VBN cord-023726-2fduzqyb 293 3 domain domain NN cord-023726-2fduzqyb 293 4 has have VBZ cord-023726-2fduzqyb 293 5 a a DT cord-023726-2fduzqyb 293 6 structure structure NN cord-023726-2fduzqyb 293 7 that that WDT cord-023726-2fduzqyb 293 8 is be VBZ cord-023726-2fduzqyb 293 9 very very RB cord-023726-2fduzqyb 293 10 different different JJ cord-023726-2fduzqyb 293 11 from from IN cord-023726-2fduzqyb 293 12 the the DT cord-023726-2fduzqyb 293 13 eightfold eightfold JJ cord-023726-2fduzqyb 293 14 β β NNP cord-023726-2fduzqyb 293 15 sandwich sandwich NN cord-023726-2fduzqyb 293 16 described describe VBN cord-023726-2fduzqyb 293 17 earlier early RBR cord-023726-2fduzqyb 293 18 ( ( -LRB- cord-023726-2fduzqyb 293 19 compare compare VB cord-023726-2fduzqyb 293 20 Fig Fig NNP cord-023726-2fduzqyb 293 21 . . . cord-023726-2fduzqyb 293 22 2.14B 2.14b CD cord-023726-2fduzqyb 293 23 with with IN cord-023726-2fduzqyb 293 24 Figs Figs NNPS cord-023726-2fduzqyb 293 25 . . . cord-023726-2fduzqyb 294 1 2.3B 2.3B NNP cord-023726-2fduzqyb 294 2 and and CC cord-023726-2fduzqyb 294 3 2.4 2.4 CD cord-023726-2fduzqyb 294 4 ) ) -RRB- cord-023726-2fduzqyb 294 5 . . . cord-023726-2fduzqyb 295 1 Instead instead RB cord-023726-2fduzqyb 295 2 , , , cord-023726-2fduzqyb 295 3 its -PRON- PRP$ cord-023726-2fduzqyb 295 4 fold fold NN cord-023726-2fduzqyb 295 5 resembles resemble VBZ cord-023726-2fduzqyb 295 6 that that DT cord-023726-2fduzqyb 295 7 of of IN cord-023726-2fduzqyb 295 8 chymotrypsin chymotrypsin NNP cord-023726-2fduzqyb 295 9 , , , cord-023726-2fduzqyb 295 10 and and CC cord-023726-2fduzqyb 295 11 it -PRON- PRP cord-023726-2fduzqyb 295 12 has have VBZ cord-023726-2fduzqyb 295 13 an an DT cord-023726-2fduzqyb 295 14 active active JJ cord-023726-2fduzqyb 295 15 site site NN cord-023726-2fduzqyb 295 16 that that WDT cord-023726-2fduzqyb 295 17 consists consist VBZ cord-023726-2fduzqyb 295 18 of of IN cord-023726-2fduzqyb 295 19 a a DT cord-023726-2fduzqyb 295 20 catalytic catalytic JJ cord-023726-2fduzqyb 295 21 triad triad NN cord-023726-2fduzqyb 295 22 whose whose WP$ cord-023726-2fduzqyb 295 23 geometry geometry NN cord-023726-2fduzqyb 295 24 is be VBZ cord-023726-2fduzqyb 295 25 identical identical JJ cord-023726-2fduzqyb 295 26 to to IN cord-023726-2fduzqyb 295 27 that that DT cord-023726-2fduzqyb 295 28 of of IN cord-023726-2fduzqyb 295 29 chymotrypsin chymotrypsin NNP cord-023726-2fduzqyb 295 30 . . . cord-023726-2fduzqyb 296 1 The the DT cord-023726-2fduzqyb 296 2 capsid capsid JJ cord-023726-2fduzqyb 296 3 protein protein NN cord-023726-2fduzqyb 296 4 is be VBZ cord-023726-2fduzqyb 296 5 an an DT cord-023726-2fduzqyb 296 6 active active JJ cord-023726-2fduzqyb 296 7 protease protease NN cord-023726-2fduzqyb 296 8 that that WDT cord-023726-2fduzqyb 296 9 cleaves cleave VBZ cord-023726-2fduzqyb 296 10 itself -PRON- PRP cord-023726-2fduzqyb 296 11 from from IN cord-023726-2fduzqyb 296 12 a a DT cord-023726-2fduzqyb 296 13 polyprotein polyprotein JJ cord-023726-2fduzqyb 296 14 precursor precursor NN cord-023726-2fduzqyb 296 15 . . . cord-023726-2fduzqyb 297 1 After after IN cord-023726-2fduzqyb 297 2 cleavage cleavage NN cord-023726-2fduzqyb 297 3 , , , cord-023726-2fduzqyb 297 4 the the DT cord-023726-2fduzqyb 297 5 C c NN cord-023726-2fduzqyb 297 6 - - HYPH cord-023726-2fduzqyb 297 7 terminal terminal NN cord-023726-2fduzqyb 297 8 tryptophan-264 tryptophan-264 NN cord-023726-2fduzqyb 297 9 remains remain VBZ cord-023726-2fduzqyb 297 10 in in IN cord-023726-2fduzqyb 297 11 the the DT cord-023726-2fduzqyb 297 12 active active JJ cord-023726-2fduzqyb 297 13 site site NN cord-023726-2fduzqyb 297 14 and and CC cord-023726-2fduzqyb 297 15 the the DT cord-023726-2fduzqyb 297 16 enzymatic enzymatic JJ cord-023726-2fduzqyb 297 17 activity activity NN cord-023726-2fduzqyb 297 18 of of IN cord-023726-2fduzqyb 297 19 the the DT cord-023726-2fduzqyb 297 20 protein protein NN cord-023726-2fduzqyb 297 21 is be VBZ cord-023726-2fduzqyb 297 22 lost lose VBN cord-023726-2fduzqyb 297 23 . . . cord-023726-2fduzqyb 298 1 The the DT cord-023726-2fduzqyb 298 2 interactions interaction NNS cord-023726-2fduzqyb 298 3 between between IN cord-023726-2fduzqyb 298 4 the the DT cord-023726-2fduzqyb 298 5 capsid capsid JJ cord-023726-2fduzqyb 298 6 protein protein NN cord-023726-2fduzqyb 298 7 subunits subunit NNS cord-023726-2fduzqyb 298 8 that that WDT cord-023726-2fduzqyb 298 9 lead lead VBP cord-023726-2fduzqyb 298 10 to to IN cord-023726-2fduzqyb 298 11 formation formation NN cord-023726-2fduzqyb 298 12 of of IN cord-023726-2fduzqyb 298 13 the the DT cord-023726-2fduzqyb 298 14 T=4 T=4 NNP cord-023726-2fduzqyb 298 15 icosahedral icosahedral JJ cord-023726-2fduzqyb 298 16 lattice lattice NN cord-023726-2fduzqyb 298 17 have have VBP cord-023726-2fduzqyb 298 18 been be VBN cord-023726-2fduzqyb 298 19 deduced deduce VBN cord-023726-2fduzqyb 298 20 by by IN cord-023726-2fduzqyb 298 21 fitting fit VBG cord-023726-2fduzqyb 298 22 the the DT cord-023726-2fduzqyb 298 23 electron electron NN cord-023726-2fduzqyb 298 24 density density NN cord-023726-2fduzqyb 298 25 of of IN cord-023726-2fduzqyb 298 26 the the DT cord-023726-2fduzqyb 298 27 capsid capsid JJ cord-023726-2fduzqyb 298 28 protein protein NN cord-023726-2fduzqyb 298 29 at at IN cord-023726-2fduzqyb 298 30 2.5-Å 2.5-å CD cord-023726-2fduzqyb 298 31 resolution resolution NN cord-023726-2fduzqyb 298 32 into into IN cord-023726-2fduzqyb 298 33 the the DT cord-023726-2fduzqyb 298 34 electron electron NN cord-023726-2fduzqyb 298 35 density density NN cord-023726-2fduzqyb 298 36 of of IN cord-023726-2fduzqyb 298 37 the the DT cord-023726-2fduzqyb 298 38 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 298 39 found find VBN cord-023726-2fduzqyb 298 40 by by IN cord-023726-2fduzqyb 298 41 cryoelectron cryoelectron NNP cord-023726-2fduzqyb 298 42 microscopy microscopy NNP cord-023726-2fduzqyb 298 43 . . . cord-023726-2fduzqyb 299 1 Such such JJ cord-023726-2fduzqyb 299 2 a a DT cord-023726-2fduzqyb 299 3 reconstruction reconstruction NN cord-023726-2fduzqyb 299 4 , , , cord-023726-2fduzqyb 299 5 based base VBN cord-023726-2fduzqyb 299 6 on on IN cord-023726-2fduzqyb 299 7 a a DT cord-023726-2fduzqyb 299 8 cryoEM cryoEM NNP cord-023726-2fduzqyb 299 9 structure structure NN cord-023726-2fduzqyb 299 10 of of IN cord-023726-2fduzqyb 299 11 Sindbis Sindbis NNP cord-023726-2fduzqyb 299 12 virus virus NN cord-023726-2fduzqyb 299 13 at at IN cord-023726-2fduzqyb 299 14 a a DT cord-023726-2fduzqyb 299 15 resolution resolution NN cord-023726-2fduzqyb 299 16 of of IN cord-023726-2fduzqyb 299 17 better well JJR cord-023726-2fduzqyb 299 18 than than IN cord-023726-2fduzqyb 299 19 10 10 CD cord-023726-2fduzqyb 299 20 Å å NN cord-023726-2fduzqyb 299 21 , , , cord-023726-2fduzqyb 299 22 is be VBZ cord-023726-2fduzqyb 299 23 shown show VBN cord-023726-2fduzqyb 299 24 in in IN cord-023726-2fduzqyb 299 25 Fig Fig NNP cord-023726-2fduzqyb 299 26 . . . cord-023726-2fduzqyb 300 1 2.14C 2.14c UH cord-023726-2fduzqyb 300 2 . . . cord-023726-2fduzqyb 301 1 The the DT cord-023726-2fduzqyb 301 2 fit fit NN cord-023726-2fduzqyb 301 3 of of IN cord-023726-2fduzqyb 301 4 the the DT cord-023726-2fduzqyb 301 5 capsid capsid JJ cord-023726-2fduzqyb 301 6 protein protein NN cord-023726-2fduzqyb 301 7 is be VBZ cord-023726-2fduzqyb 301 8 unique unique JJ cord-023726-2fduzqyb 301 9 and and CC cord-023726-2fduzqyb 301 10 the the DT cord-023726-2fduzqyb 301 11 combined combined JJ cord-023726-2fduzqyb 301 12 approaches approach NNS cord-023726-2fduzqyb 301 13 of of IN cord-023726-2fduzqyb 301 14 X x NN cord-023726-2fduzqyb 301 15 - - NN cord-023726-2fduzqyb 301 16 ray ray NN cord-023726-2fduzqyb 301 17 crystallography crystallography NN cord-023726-2fduzqyb 301 18 and and CC cord-023726-2fduzqyb 301 19 cryoelectron cryoelectron NNP cord-023726-2fduzqyb 301 20 microscopy microscopy NNP cord-023726-2fduzqyb 301 21 thus thus RB cord-023726-2fduzqyb 301 22 define define VBP cord-023726-2fduzqyb 301 23 the the DT cord-023726-2fduzqyb 301 24 structure structure NN cord-023726-2fduzqyb 301 25 of of IN cord-023726-2fduzqyb 301 26 the the DT cord-023726-2fduzqyb 301 27 shell shell NN cord-023726-2fduzqyb 301 28 of of IN cord-023726-2fduzqyb 301 29 the the DT cord-023726-2fduzqyb 301 30 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 301 31 to to IN cord-023726-2fduzqyb 301 32 atomic atomic JJ cord-023726-2fduzqyb 301 33 resolution resolution NN cord-023726-2fduzqyb 301 34 . . . cord-023726-2fduzqyb 302 1 The the DT cord-023726-2fduzqyb 302 2 envelopes envelope NNS cord-023726-2fduzqyb 302 3 of of IN cord-023726-2fduzqyb 302 4 alphaviruses alphavirus NNS cord-023726-2fduzqyb 302 5 contain contain VBP cord-023726-2fduzqyb 302 6 240 240 CD cord-023726-2fduzqyb 302 7 copies copy NNS cord-023726-2fduzqyb 302 8 of of IN cord-023726-2fduzqyb 302 9 each each DT cord-023726-2fduzqyb 302 10 of of IN cord-023726-2fduzqyb 302 11 two two CD cord-023726-2fduzqyb 302 12 virus virus NN cord-023726-2fduzqyb 302 13 - - HYPH cord-023726-2fduzqyb 302 14 encoded encode VBN cord-023726-2fduzqyb 302 15 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 302 16 , , , cord-023726-2fduzqyb 302 17 called call VBN cord-023726-2fduzqyb 302 18 E1 E1 NNP cord-023726-2fduzqyb 302 19 and and CC cord-023726-2fduzqyb 302 20 E2 E2 NNP cord-023726-2fduzqyb 302 21 . . . cord-023726-2fduzqyb 303 1 E2 E2 NNP cord-023726-2fduzqyb 303 2 is be VBZ cord-023726-2fduzqyb 303 3 first first RB cord-023726-2fduzqyb 303 4 produced produce VBN cord-023726-2fduzqyb 303 5 as as IN cord-023726-2fduzqyb 303 6 a a DT cord-023726-2fduzqyb 303 7 precursor precursor NN cord-023726-2fduzqyb 303 8 called call VBN cord-023726-2fduzqyb 303 9 PE2 PE2 NNP cord-023726-2fduzqyb 303 10 . . . cord-023726-2fduzqyb 304 1 E1 E1 NNP cord-023726-2fduzqyb 304 2 and and CC cord-023726-2fduzqyb 304 3 PE2 PE2 NNP cord-023726-2fduzqyb 304 4 form form VBP cord-023726-2fduzqyb 304 5 a a DT cord-023726-2fduzqyb 304 6 heterodimer heterodimer NN cord-023726-2fduzqyb 304 7 shortly shortly RB cord-023726-2fduzqyb 304 8 after after IN cord-023726-2fduzqyb 304 9 synthesis synthesis NN cord-023726-2fduzqyb 304 10 , , , cord-023726-2fduzqyb 304 11 and and CC cord-023726-2fduzqyb 304 12 both both DT cord-023726-2fduzqyb 304 13 span span VBP cord-023726-2fduzqyb 304 14 the the DT cord-023726-2fduzqyb 304 15 lipid lipid NN cord-023726-2fduzqyb 304 16 bilayer bilayer NN cord-023726-2fduzqyb 304 17 as as IN cord-023726-2fduzqyb 304 18 Type Type NNP cord-023726-2fduzqyb 304 19 I -PRON- PRP cord-023726-2fduzqyb 304 20 integral integral JJ cord-023726-2fduzqyb 304 21 membrane membrane NN cord-023726-2fduzqyb 304 22 proteins protein NNS cord-023726-2fduzqyb 304 23 ( ( -LRB- cord-023726-2fduzqyb 304 24 having have VBG cord-023726-2fduzqyb 304 25 a a DT cord-023726-2fduzqyb 304 26 membrane membrane NN cord-023726-2fduzqyb 304 27 - - HYPH cord-023726-2fduzqyb 304 28 spanning span VBG cord-023726-2fduzqyb 304 29 anchor anchor NN cord-023726-2fduzqyb 304 30 at at IN cord-023726-2fduzqyb 304 31 or or CC cord-023726-2fduzqyb 304 32 near near IN cord-023726-2fduzqyb 304 33 the the DT cord-023726-2fduzqyb 304 34 C C NNP cord-023726-2fduzqyb 304 35 terminus terminus NN cord-023726-2fduzqyb 304 36 ) ) -RRB- cord-023726-2fduzqyb 304 37 . . . cord-023726-2fduzqyb 305 1 The the DT cord-023726-2fduzqyb 305 2 C c NN cord-023726-2fduzqyb 305 3 - - HYPH cord-023726-2fduzqyb 305 4 terminal terminal JJ cord-023726-2fduzqyb 305 5 cytoplasmic cytoplasmic JJ cord-023726-2fduzqyb 305 6 extension extension NN cord-023726-2fduzqyb 305 7 of of IN cord-023726-2fduzqyb 305 8 PE2 PE2 NNP cord-023726-2fduzqyb 305 9 interacts interact VBZ cord-023726-2fduzqyb 305 10 in in IN cord-023726-2fduzqyb 305 11 a a DT cord-023726-2fduzqyb 305 12 specific specific JJ cord-023726-2fduzqyb 305 13 fashion fashion NN cord-023726-2fduzqyb 305 14 with with IN cord-023726-2fduzqyb 305 15 a a DT cord-023726-2fduzqyb 305 16 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 305 17 protein protein NN cord-023726-2fduzqyb 305 18 so so IN cord-023726-2fduzqyb 305 19 that that IN cord-023726-2fduzqyb 305 20 there there EX cord-023726-2fduzqyb 305 21 is be VBZ cord-023726-2fduzqyb 305 22 a a DT cord-023726-2fduzqyb 305 23 one one CD cord-023726-2fduzqyb 305 24 - - HYPH cord-023726-2fduzqyb 305 25 to to IN cord-023726-2fduzqyb 305 26 - - HYPH cord-023726-2fduzqyb 305 27 one one CD cord-023726-2fduzqyb 305 28 correspondance correspondance NN cord-023726-2fduzqyb 305 29 between between IN cord-023726-2fduzqyb 305 30 a a DT cord-023726-2fduzqyb 305 31 capsid capsid JJ cord-023726-2fduzqyb 305 32 protein protein NN cord-023726-2fduzqyb 305 33 and and CC cord-023726-2fduzqyb 305 34 a a DT cord-023726-2fduzqyb 305 35 glycoprotein glycoprotein NN cord-023726-2fduzqyb 305 36 heterodimer heterodimer NN cord-023726-2fduzqyb 305 37 . . . cord-023726-2fduzqyb 306 1 The the DT cord-023726-2fduzqyb 306 2 240 240 CD cord-023726-2fduzqyb 306 3 glycoprotein glycoprotein NN cord-023726-2fduzqyb 306 4 heterodimers heterodimer NNS cord-023726-2fduzqyb 306 5 form form VBP cord-023726-2fduzqyb 306 6 a a DT cord-023726-2fduzqyb 306 7 T=4 T=4 NNP cord-023726-2fduzqyb 306 8 icosahedral icosahedral JJ cord-023726-2fduzqyb 306 9 lattice lattice NN cord-023726-2fduzqyb 306 10 on on IN cord-023726-2fduzqyb 306 11 the the DT cord-023726-2fduzqyb 306 12 surface surface NN cord-023726-2fduzqyb 306 13 of of IN cord-023726-2fduzqyb 306 14 the the DT cord-023726-2fduzqyb 306 15 particle particle NN cord-023726-2fduzqyb 306 16 by by IN cord-023726-2fduzqyb 306 17 interacting interact VBG cord-023726-2fduzqyb 306 18 with with IN cord-023726-2fduzqyb 306 19 one one CD cord-023726-2fduzqyb 306 20 another another DT cord-023726-2fduzqyb 306 21 and and CC cord-023726-2fduzqyb 306 22 with with IN cord-023726-2fduzqyb 306 23 the the DT cord-023726-2fduzqyb 306 24 capsid capsid NN cord-023726-2fduzqyb 306 25 proteins protein NNS cord-023726-2fduzqyb 306 26 . . . cord-023726-2fduzqyb 307 1 Because because IN cord-023726-2fduzqyb 307 2 of of IN cord-023726-2fduzqyb 307 3 the the DT cord-023726-2fduzqyb 307 4 glycoprotein glycoprotein NN cord-023726-2fduzqyb 307 5 - - HYPH cord-023726-2fduzqyb 307 6 capsid capsid VBG cord-023726-2fduzqyb 307 7 protein protein NN cord-023726-2fduzqyb 307 8 interactions interaction NNS cord-023726-2fduzqyb 307 9 , , , cord-023726-2fduzqyb 307 10 the the DT cord-023726-2fduzqyb 307 11 icosahedral icosahedral JJ cord-023726-2fduzqyb 307 12 lattices lattice NNS cord-023726-2fduzqyb 307 13 of of IN cord-023726-2fduzqyb 307 14 the the DT cord-023726-2fduzqyb 307 15 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 307 16 and and CC cord-023726-2fduzqyb 307 17 the the DT cord-023726-2fduzqyb 307 18 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 307 19 are be VBP cord-023726-2fduzqyb 307 20 coordinated coordinate VBN cord-023726-2fduzqyb 307 21 . . . cord-023726-2fduzqyb 308 1 At at IN cord-023726-2fduzqyb 308 2 some some DT cord-023726-2fduzqyb 308 3 time time NN cord-023726-2fduzqyb 308 4 during during IN cord-023726-2fduzqyb 308 5 transport transport NN cord-023726-2fduzqyb 308 6 of of IN cord-023726-2fduzqyb 308 7 the the DT cord-023726-2fduzqyb 308 8 glycoprotein glycoprotein NN cord-023726-2fduzqyb 308 9 heterodimers heterodimer NNS cord-023726-2fduzqyb 308 10 to to IN cord-023726-2fduzqyb 308 11 the the DT cord-023726-2fduzqyb 308 12 cell cell NN cord-023726-2fduzqyb 308 13 surface surface NN cord-023726-2fduzqyb 308 14 , , , cord-023726-2fduzqyb 308 15 PE2 PE2 NNP cord-023726-2fduzqyb 308 16 is be VBZ cord-023726-2fduzqyb 308 17 cleaved cleave VBN cord-023726-2fduzqyb 308 18 by by IN cord-023726-2fduzqyb 308 19 a a DT cord-023726-2fduzqyb 308 20 cellular cellular JJ cord-023726-2fduzqyb 308 21 protease protease NN cord-023726-2fduzqyb 308 22 called call VBN cord-023726-2fduzqyb 308 23 furin furin NN cord-023726-2fduzqyb 308 24 to to TO cord-023726-2fduzqyb 308 25 form form VB cord-023726-2fduzqyb 308 26 E2 E2 NNP cord-023726-2fduzqyb 308 27 . . . cord-023726-2fduzqyb 309 1 E1 E1 NNP cord-023726-2fduzqyb 309 2 and and CC cord-023726-2fduzqyb 309 3 E2 E2 NNP cord-023726-2fduzqyb 309 4 remain remain VBP cord-023726-2fduzqyb 309 5 associated associated JJ cord-023726-2fduzqyb 309 6 as as IN cord-023726-2fduzqyb 309 7 a a DT cord-023726-2fduzqyb 309 8 heterodimer heterodimer NN cord-023726-2fduzqyb 309 9 . . . cord-023726-2fduzqyb 310 1 If if IN cord-023726-2fduzqyb 310 2 cleavage cleavage NN cord-023726-2fduzqyb 310 3 is be VBZ cord-023726-2fduzqyb 310 4 prevented prevent VBN cord-023726-2fduzqyb 310 5 , , , cord-023726-2fduzqyb 310 6 noninfectious noninfectious JJ cord-023726-2fduzqyb 310 7 particles particle NNS cord-023726-2fduzqyb 310 8 are be VBP cord-023726-2fduzqyb 310 9 produced produce VBN cord-023726-2fduzqyb 310 10 that that WDT cord-023726-2fduzqyb 310 11 contain contain VBP cord-023726-2fduzqyb 310 12 PE2 PE2 NNP cord-023726-2fduzqyb 310 13 and and CC cord-023726-2fduzqyb 310 14 E1 E1 NNP cord-023726-2fduzqyb 310 15 . . . cord-023726-2fduzqyb 311 1 In in IN cord-023726-2fduzqyb 311 2 the the DT cord-023726-2fduzqyb 311 3 virion virion NN cord-023726-2fduzqyb 311 4 , , , cord-023726-2fduzqyb 311 5 three three CD cord-023726-2fduzqyb 311 6 glycoprotein glycoprotein NN cord-023726-2fduzqyb 311 7 heterodimers heterodimer NNS cord-023726-2fduzqyb 311 8 associate associate JJ cord-023726-2fduzqyb 311 9 to to TO cord-023726-2fduzqyb 311 10 form form VB cord-023726-2fduzqyb 311 11 a a DT cord-023726-2fduzqyb 311 12 trimeric trimeric JJ cord-023726-2fduzqyb 311 13 structure structure NN cord-023726-2fduzqyb 311 14 called call VBD cord-023726-2fduzqyb 311 15 a a DT cord-023726-2fduzqyb 311 16 spike spike NN cord-023726-2fduzqyb 311 17 , , , cord-023726-2fduzqyb 311 18 easily easily RB cord-023726-2fduzqyb 311 19 seen see VBN cord-023726-2fduzqyb 311 20 in in IN cord-023726-2fduzqyb 311 21 Figs fig NNS cord-023726-2fduzqyb 311 22 . . . cord-023726-2fduzqyb 312 1 2.5 2.5 CD cord-023726-2fduzqyb 312 2 and and CC cord-023726-2fduzqyb 312 3 2.14A. 2.14a. CD cord-023726-2fduzqyb 313 1 It -PRON- PRP cord-023726-2fduzqyb 313 2 is be VBZ cord-023726-2fduzqyb 313 3 not not RB cord-023726-2fduzqyb 313 4 known know VBN cord-023726-2fduzqyb 313 5 if if IN cord-023726-2fduzqyb 313 6 the the DT cord-023726-2fduzqyb 313 7 spike spike NN cord-023726-2fduzqyb 313 8 assembles assemble VBZ cord-023726-2fduzqyb 313 9 during during IN cord-023726-2fduzqyb 313 10 virus virus NN cord-023726-2fduzqyb 313 11 assembly assembly NN cord-023726-2fduzqyb 313 12 or or CC cord-023726-2fduzqyb 313 13 if if IN cord-023726-2fduzqyb 313 14 heterodimers heterodimer NNS cord-023726-2fduzqyb 313 15 trimerize trimerize NNP cord-023726-2fduzqyb 313 16 during during IN cord-023726-2fduzqyb 313 17 their -PRON- PRP$ cord-023726-2fduzqyb 313 18 transport transport NN cord-023726-2fduzqyb 313 19 to to IN cord-023726-2fduzqyb 313 20 the the DT cord-023726-2fduzqyb 313 21 cell cell NN cord-023726-2fduzqyb 313 22 surface surface NN cord-023726-2fduzqyb 313 23 . . . cord-023726-2fduzqyb 314 1 A a DT cord-023726-2fduzqyb 314 2 reconstruction reconstruction NN cord-023726-2fduzqyb 314 3 of of IN cord-023726-2fduzqyb 314 4 a a DT cord-023726-2fduzqyb 314 5 spike spike NN cord-023726-2fduzqyb 314 6 of of IN cord-023726-2fduzqyb 314 7 Sindbis Sindbis NNP cord-023726-2fduzqyb 314 8 virus virus NN cord-023726-2fduzqyb 314 9 at at IN cord-023726-2fduzqyb 314 10 a a DT cord-023726-2fduzqyb 314 11 resolution resolution NN cord-023726-2fduzqyb 314 12 better well JJR cord-023726-2fduzqyb 314 13 than than IN cord-023726-2fduzqyb 314 14 10 10 CD cord-023726-2fduzqyb 314 15 Å å NN cord-023726-2fduzqyb 314 16 is be VBZ cord-023726-2fduzqyb 314 17 shown show VBN cord-023726-2fduzqyb 314 18 in in IN cord-023726-2fduzqyb 314 19 Fig Fig NNP cord-023726-2fduzqyb 314 20 . . . cord-023726-2fduzqyb 315 1 2 2 LS cord-023726-2fduzqyb 315 2 .15A. .15A. . cord-023726-2fduzqyb 316 1 In in IN cord-023726-2fduzqyb 316 2 this this DT cord-023726-2fduzqyb 316 3 reconstruction reconstruction NN cord-023726-2fduzqyb 316 4 , , , cord-023726-2fduzqyb 316 5 the the DT cord-023726-2fduzqyb 316 6 electron electron NN cord-023726-2fduzqyb 316 7 density density NN cord-023726-2fduzqyb 316 8 of of IN cord-023726-2fduzqyb 316 9 E1 E1 NNP cord-023726-2fduzqyb 316 10 has have VBZ cord-023726-2fduzqyb 316 11 been be VBN cord-023726-2fduzqyb 316 12 replaced replace VBN cord-023726-2fduzqyb 316 13 by by IN cord-023726-2fduzqyb 316 14 the the DT cord-023726-2fduzqyb 316 15 E1 E1 NNP cord-023726-2fduzqyb 316 16 structure structure NN cord-023726-2fduzqyb 316 17 of of IN cord-023726-2fduzqyb 316 18 the the DT cord-023726-2fduzqyb 316 19 related related JJ cord-023726-2fduzqyb 316 20 Semliki Semliki NNP cord-023726-2fduzqyb 316 21 Forest Forest NNP cord-023726-2fduzqyb 316 22 virus virus NN cord-023726-2fduzqyb 316 23 determined determine VBN cord-023726-2fduzqyb 316 24 to to IN cord-023726-2fduzqyb 316 25 atomic atomic JJ cord-023726-2fduzqyb 316 26 resolution resolution NN cord-023726-2fduzqyb 316 27 by by IN cord-023726-2fduzqyb 316 28 X x NN cord-023726-2fduzqyb 316 29 - - NN cord-023726-2fduzqyb 316 30 ray ray NN cord-023726-2fduzqyb 316 31 crystallography crystallography NN cord-023726-2fduzqyb 316 32 . . . cord-023726-2fduzqyb 317 1 The the DT cord-023726-2fduzqyb 317 2 three three CD cord-023726-2fduzqyb 317 3 copies copy NNS cord-023726-2fduzqyb 317 4 of of IN cord-023726-2fduzqyb 317 5 E1 e1 NN cord-023726-2fduzqyb 317 6 project project NN cord-023726-2fduzqyb 317 7 upwards upwards RB cord-023726-2fduzqyb 317 8 at at IN cord-023726-2fduzqyb 317 9 an an DT cord-023726-2fduzqyb 317 10 angle angle NN cord-023726-2fduzqyb 317 11 of of IN cord-023726-2fduzqyb 317 12 about about IN cord-023726-2fduzqyb 317 13 45 45 CD cord-023726-2fduzqyb 317 14 ° ° NNS cord-023726-2fduzqyb 317 15 and and CC cord-023726-2fduzqyb 317 16 are be VBP cord-023726-2fduzqyb 317 17 shown show VBN cord-023726-2fduzqyb 317 18 in in IN cord-023726-2fduzqyb 317 19 three three CD cord-023726-2fduzqyb 317 20 colors color NNS cord-023726-2fduzqyb 317 21 because because IN cord-023726-2fduzqyb 317 22 they -PRON- PRP cord-023726-2fduzqyb 317 23 have have VBP cord-023726-2fduzqyb 317 24 slightly slightly RB cord-023726-2fduzqyb 317 25 dif- dif- . cord-023726-2fduzqyb 318 1 B. B. NNP cord-023726-2fduzqyb 318 2 Dengue Dengue NNP cord-023726-2fduzqyb 318 3 Virus Virus NNP cord-023726-2fduzqyb 318 4 FIGURE figure NN cord-023726-2fduzqyb 319 1 2.15 2.15 CD cord-023726-2fduzqyb 319 2 Comparison comparison NN cord-023726-2fduzqyb 319 3 of of IN cord-023726-2fduzqyb 319 4 ( ( -LRB- cord-023726-2fduzqyb 319 5 A a NN cord-023726-2fduzqyb 319 6 ) ) -RRB- cord-023726-2fduzqyb 319 7 the the DT cord-023726-2fduzqyb 319 8 spike spike NN cord-023726-2fduzqyb 319 9 structure structure NN cord-023726-2fduzqyb 319 10 of of IN cord-023726-2fduzqyb 319 11 mature mature JJ cord-023726-2fduzqyb 319 12 Sindbis Sindbis NNP cord-023726-2fduzqyb 319 13 virus virus NN cord-023726-2fduzqyb 319 14 ( ( -LRB- cord-023726-2fduzqyb 319 15 an an DT cord-023726-2fduzqyb 319 16 alphavirus alphavirus NNP cord-023726-2fduzqyb 319 17 ) ) -RRB- cord-023726-2fduzqyb 319 18 with with IN cord-023726-2fduzqyb 319 19 ( ( -LRB- cord-023726-2fduzqyb 319 20 B b NN cord-023726-2fduzqyb 319 21 ) ) -RRB- cord-023726-2fduzqyb 320 1 the the DT cord-023726-2fduzqyb 320 2 spike spike NN cord-023726-2fduzqyb 320 3 of of IN cord-023726-2fduzqyb 320 4 immature immature JJ cord-023726-2fduzqyb 320 5 dengue dengue NN cord-023726-2fduzqyb 320 6 virus virus NN cord-023726-2fduzqyb 320 7 ( ( -LRB- cord-023726-2fduzqyb 320 8 a a DT cord-023726-2fduzqyb 320 9 flavivirus flavivirus NN cord-023726-2fduzqyb 320 10 ) ) -RRB- cord-023726-2fduzqyb 320 11 . . . cord-023726-2fduzqyb 321 1 The the DT cord-023726-2fduzqyb 321 2 Cα Cα NNP cord-023726-2fduzqyb 321 3 backbones backbone NNS cord-023726-2fduzqyb 321 4 of of IN cord-023726-2fduzqyb 321 5 the the DT cord-023726-2fduzqyb 321 6 three three CD cord-023726-2fduzqyb 321 7 E1 e1 NN cord-023726-2fduzqyb 321 8 ( ( -LRB- cord-023726-2fduzqyb 321 9 Sindbis Sindbis NNP cord-023726-2fduzqyb 321 10 ) ) -RRB- cord-023726-2fduzqyb 321 11 and and CC cord-023726-2fduzqyb 321 12 E e NN cord-023726-2fduzqyb 321 13 ( ( -LRB- cord-023726-2fduzqyb 321 14 dengue dengue NN cord-023726-2fduzqyb 321 15 ) ) -RRB- cord-023726-2fduzqyb 321 16 glycoprotein glycoprotein NN cord-023726-2fduzqyb 321 17 ectodomains ectodomain NNS cord-023726-2fduzqyb 321 18 are be VBP cord-023726-2fduzqyb 321 19 shown show VBN cord-023726-2fduzqyb 321 20 in in IN cord-023726-2fduzqyb 321 21 red red JJ cord-023726-2fduzqyb 321 22 , , , cord-023726-2fduzqyb 321 23 green green JJ cord-023726-2fduzqyb 321 24 , , , cord-023726-2fduzqyb 321 25 and and CC cord-023726-2fduzqyb 321 26 blue blue JJ cord-023726-2fduzqyb 321 27 , , , cord-023726-2fduzqyb 321 28 as as IN cord-023726-2fduzqyb 321 29 they -PRON- PRP cord-023726-2fduzqyb 321 30 were be VBD cord-023726-2fduzqyb 321 31 fitted fit VBN cord-023726-2fduzqyb 321 32 into into IN cord-023726-2fduzqyb 321 33 the the DT cord-023726-2fduzqyb 321 34 cryoelectron cryoelectron NNP cord-023726-2fduzqyb 321 35 density density NN cord-023726-2fduzqyb 321 36 envelope envelope NN cord-023726-2fduzqyb 321 37 . . . cord-023726-2fduzqyb 322 1 The the DT cord-023726-2fduzqyb 322 2 E1 e1 NN cord-023726-2fduzqyb 322 3 and and CC cord-023726-2fduzqyb 322 4 E e NN cord-023726-2fduzqyb 322 5 densities density NNS cord-023726-2fduzqyb 322 6 have have VBP cord-023726-2fduzqyb 322 7 been be VBN cord-023726-2fduzqyb 322 8 zeroed zero VBN cord-023726-2fduzqyb 322 9 out out RP cord-023726-2fduzqyb 322 10 , , , cord-023726-2fduzqyb 322 11 leaving leave VBG cord-023726-2fduzqyb 322 12 the the DT cord-023726-2fduzqyb 322 13 gray gray JJ cord-023726-2fduzqyb 322 14 envelope envelope NN cord-023726-2fduzqyb 322 15 that that WDT cord-023726-2fduzqyb 322 16 corresponds correspond VBZ cord-023726-2fduzqyb 322 17 to to IN cord-023726-2fduzqyb 322 18 E2 E2 NNP cord-023726-2fduzqyb 322 19 for for IN cord-023726-2fduzqyb 322 20 Sindbis Sindbis NNP cord-023726-2fduzqyb 322 21 and and CC cord-023726-2fduzqyb 322 22 prM prm JJ cord-023726-2fduzqyb 322 23 for for IN cord-023726-2fduzqyb 322 24 dengue dengue NN cord-023726-2fduzqyb 322 25 . . . cord-023726-2fduzqyb 323 1 The the DT cord-023726-2fduzqyb 323 2 density density NN cord-023726-2fduzqyb 323 3 corresponding correspond VBG cord-023726-2fduzqyb 323 4 to to IN cord-023726-2fduzqyb 323 5 the the DT cord-023726-2fduzqyb 323 6 lipid lipid NN cord-023726-2fduzqyb 323 7 bilayer bilayer NN cord-023726-2fduzqyb 323 8 is be VBZ cord-023726-2fduzqyb 323 9 shown show VBN cord-023726-2fduzqyb 323 10 in in IN cord-023726-2fduzqyb 323 11 bright bright JJ cord-023726-2fduzqyb 323 12 green green NN cord-023726-2fduzqyb 323 13 . . . cord-023726-2fduzqyb 324 1 Adapted adapt VBN cord-023726-2fduzqyb 324 2 from from IN cord-023726-2fduzqyb 324 3 Figure figure NN cord-023726-2fduzqyb 324 4 5 5 CD cord-023726-2fduzqyb 324 5 in in IN cord-023726-2fduzqyb 324 6 Y. Y. NNP cord-023726-2fduzqyb 324 7 with with IN cord-023726-2fduzqyb 324 8 permission permission NN cord-023726-2fduzqyb 324 9 . . . cord-023726-2fduzqyb 325 1 ferent ferent NN cord-023726-2fduzqyb 325 2 environments environment NNS cord-023726-2fduzqyb 325 3 . . . cord-023726-2fduzqyb 326 1 The the DT cord-023726-2fduzqyb 326 2 electron electron NN cord-023726-2fduzqyb 326 3 density density NN cord-023726-2fduzqyb 326 4 in in IN cord-023726-2fduzqyb 326 5 gray gray NN cord-023726-2fduzqyb 326 6 that that WDT cord-023726-2fduzqyb 326 7 remains remain VBZ cord-023726-2fduzqyb 326 8 after after IN cord-023726-2fduzqyb 326 9 subtracting subtract VBG cord-023726-2fduzqyb 326 10 the the DT cord-023726-2fduzqyb 326 11 density density NN cord-023726-2fduzqyb 326 12 due due JJ cord-023726-2fduzqyb 326 13 to to IN cord-023726-2fduzqyb 326 14 E1 E1 NNP cord-023726-2fduzqyb 326 15 is be VBZ cord-023726-2fduzqyb 326 16 thus thus RB cord-023726-2fduzqyb 326 17 the the DT cord-023726-2fduzqyb 326 18 electron electron NN cord-023726-2fduzqyb 326 19 density density NN cord-023726-2fduzqyb 326 20 of of IN cord-023726-2fduzqyb 326 21 E2 E2 NNP cord-023726-2fduzqyb 326 22 . . . cord-023726-2fduzqyb 327 1 E2 E2 NNP cord-023726-2fduzqyb 327 2 projects project NNS cord-023726-2fduzqyb 327 3 further far RBR cord-023726-2fduzqyb 327 4 upward upward RB cord-023726-2fduzqyb 327 5 than than IN cord-023726-2fduzqyb 327 6 does do VBZ cord-023726-2fduzqyb 327 7 E1 E1 NNP cord-023726-2fduzqyb 327 8 and and CC cord-023726-2fduzqyb 327 9 covers cover VBZ cord-023726-2fduzqyb 327 10 the the DT cord-023726-2fduzqyb 327 11 apex apex NN cord-023726-2fduzqyb 327 12 of of IN cord-023726-2fduzqyb 327 13 E1 E1 NNP cord-023726-2fduzqyb 327 14 , , , cord-023726-2fduzqyb 327 15 which which WDT cord-023726-2fduzqyb 327 16 has have VBZ cord-023726-2fduzqyb 327 17 the the DT cord-023726-2fduzqyb 327 18 fusion fusion NN cord-023726-2fduzqyb 327 19 peptide peptide NN cord-023726-2fduzqyb 327 20 . . . cord-023726-2fduzqyb 328 1 Thus thus RB cord-023726-2fduzqyb 328 2 , , , cord-023726-2fduzqyb 328 3 E2 E2 NNP cord-023726-2fduzqyb 328 4 covers cover VBZ cord-023726-2fduzqyb 328 5 the the DT cord-023726-2fduzqyb 328 6 fusion fusion NN cord-023726-2fduzqyb 328 7 peptide peptide NN cord-023726-2fduzqyb 328 8 with with IN cord-023726-2fduzqyb 328 9 a a DT cord-023726-2fduzqyb 328 10 hydrophobic hydrophobic JJ cord-023726-2fduzqyb 328 11 pocket pocket NN cord-023726-2fduzqyb 328 12 so so IN cord-023726-2fduzqyb 328 13 that that IN cord-023726-2fduzqyb 328 14 it -PRON- PRP cord-023726-2fduzqyb 328 15 does do VBZ cord-023726-2fduzqyb 328 16 not not RB cord-023726-2fduzqyb 328 17 interact interact VB cord-023726-2fduzqyb 328 18 with with IN cord-023726-2fduzqyb 328 19 the the DT cord-023726-2fduzqyb 328 20 hydrophilic hydrophilic JJ cord-023726-2fduzqyb 328 21 environment environment NN cord-023726-2fduzqyb 328 22 . . . cord-023726-2fduzqyb 329 1 The the DT cord-023726-2fduzqyb 329 2 apex apex NN cord-023726-2fduzqyb 329 3 of of IN cord-023726-2fduzqyb 329 4 the the DT cord-023726-2fduzqyb 329 5 E2 E2 NNP cord-023726-2fduzqyb 329 6 spike spike NN cord-023726-2fduzqyb 329 7 contains contain VBZ cord-023726-2fduzqyb 329 8 the the DT cord-023726-2fduzqyb 329 9 domains domain NNS cord-023726-2fduzqyb 329 10 that that WDT cord-023726-2fduzqyb 329 11 attach attach VBP cord-023726-2fduzqyb 329 12 to to IN cord-023726-2fduzqyb 329 13 receptors receptor NNS cord-023726-2fduzqyb 329 14 on on IN cord-023726-2fduzqyb 329 15 a a DT cord-023726-2fduzqyb 329 16 susceptible susceptible JJ cord-023726-2fduzqyb 329 17 cell cell NN cord-023726-2fduzqyb 329 18 . . . cord-023726-2fduzqyb 330 1 Both both DT cord-023726-2fduzqyb 330 2 E1 E1 NNP cord-023726-2fduzqyb 330 3 and and CC cord-023726-2fduzqyb 330 4 E2 E2 NNP cord-023726-2fduzqyb 330 5 have have VBP cord-023726-2fduzqyb 330 6 C c NN cord-023726-2fduzqyb 330 7 - - HYPH cord-023726-2fduzqyb 330 8 terminal terminal NN cord-023726-2fduzqyb 330 9 membrane membrane NN cord-023726-2fduzqyb 330 10 - - HYPH cord-023726-2fduzqyb 330 11 spanning span VBG cord-023726-2fduzqyb 330 12 anchors anchor NNS cord-023726-2fduzqyb 330 13 that that WDT cord-023726-2fduzqyb 330 14 traverse traverse VBP cord-023726-2fduzqyb 330 15 the the DT cord-023726-2fduzqyb 330 16 lipid lipid NN cord-023726-2fduzqyb 330 17 bilayer bilayer NN cord-023726-2fduzqyb 330 18 shown show VBN cord-023726-2fduzqyb 330 19 in in IN cord-023726-2fduzqyb 330 20 green green JJ cord-023726-2fduzqyb 330 21 . . . cord-023726-2fduzqyb 331 1 The the DT cord-023726-2fduzqyb 331 2 C c NN cord-023726-2fduzqyb 331 3 - - HYPH cord-023726-2fduzqyb 331 4 terminal terminal NN cord-023726-2fduzqyb 331 5 domain domain NN cord-023726-2fduzqyb 331 6 of of IN cord-023726-2fduzqyb 331 7 E1 e1 NN cord-023726-2fduzqyb 331 8 is be VBZ cord-023726-2fduzqyb 331 9 not not RB cord-023726-2fduzqyb 331 10 present present JJ cord-023726-2fduzqyb 331 11 in in IN cord-023726-2fduzqyb 331 12 the the DT cord-023726-2fduzqyb 331 13 protein protein NN cord-023726-2fduzqyb 331 14 whose whose WP$ cord-023726-2fduzqyb 331 15 structure structure NN cord-023726-2fduzqyb 331 16 has have VBZ cord-023726-2fduzqyb 331 17 been be VBN cord-023726-2fduzqyb 331 18 determined determine VBN cord-023726-2fduzqyb 331 19 because because IN cord-023726-2fduzqyb 331 20 hydrophobic hydrophobic JJ cord-023726-2fduzqyb 331 21 domains domain NNS cord-023726-2fduzqyb 331 22 do do VBP cord-023726-2fduzqyb 331 23 not not RB cord-023726-2fduzqyb 331 24 easily easily RB cord-023726-2fduzqyb 331 25 crystallize crystallize VB cord-023726-2fduzqyb 331 26 . . . cord-023726-2fduzqyb 332 1 Thus thus RB cord-023726-2fduzqyb 332 2 , , , cord-023726-2fduzqyb 332 3 the the DT cord-023726-2fduzqyb 332 4 electron electron NN cord-023726-2fduzqyb 332 5 density density NN cord-023726-2fduzqyb 332 6 shown show VBN cord-023726-2fduzqyb 332 7 traversing traverse VBG cord-023726-2fduzqyb 332 8 the the DT cord-023726-2fduzqyb 332 9 lipid lipid NN cord-023726-2fduzqyb 332 10 bilayer bilayer NN cord-023726-2fduzqyb 332 11 arises arise VBZ cord-023726-2fduzqyb 332 12 from from IN cord-023726-2fduzqyb 332 13 both both CC cord-023726-2fduzqyb 332 14 E1 E1 NNP cord-023726-2fduzqyb 332 15 and and CC cord-023726-2fduzqyb 332 16 E2 E2 NNP cord-023726-2fduzqyb 332 17 and and CC cord-023726-2fduzqyb 332 18 shows show VBZ cord-023726-2fduzqyb 332 19 that that IN cord-023726-2fduzqyb 332 20 the the DT cord-023726-2fduzqyb 332 21 two two CD cord-023726-2fduzqyb 332 22 membrane membrane NN cord-023726-2fduzqyb 332 23 spanning span VBG cord-023726-2fduzqyb 332 24 anchors anchor NNS cord-023726-2fduzqyb 332 25 go go VBP cord-023726-2fduzqyb 332 26 through through RB cord-023726-2fduzqyb 332 27 as as IN cord-023726-2fduzqyb 332 28 paired pair VBN cord-023726-2fduzqyb 332 29 α α NNP cord-023726-2fduzqyb 332 30 helical helical JJ cord-023726-2fduzqyb 332 31 structures structure NNS cord-023726-2fduzqyb 332 32 ( ( -LRB- cord-023726-2fduzqyb 332 33 Fig Fig NNP cord-023726-2fduzqyb 332 34 . . . cord-023726-2fduzqyb 332 35 2.16 2.16 CD cord-023726-2fduzqyb 332 36 ) ) -RRB- cord-023726-2fduzqyb 332 37 . . . cord-023726-2fduzqyb 333 1 Upon upon IN cord-023726-2fduzqyb 333 2 entry entry NN cord-023726-2fduzqyb 333 3 of of IN cord-023726-2fduzqyb 333 4 an an DT cord-023726-2fduzqyb 333 5 alphavirus alphavirus NN cord-023726-2fduzqyb 333 6 into into IN cord-023726-2fduzqyb 333 7 a a DT cord-023726-2fduzqyb 333 8 cell cell NN cord-023726-2fduzqyb 333 9 , , , cord-023726-2fduzqyb 333 10 the the DT cord-023726-2fduzqyb 333 11 acidic acidic JJ cord-023726-2fduzqyb 333 12 pH ph NN cord-023726-2fduzqyb 333 13 of of IN cord-023726-2fduzqyb 333 14 endosomal endosomal NNP cord-023726-2fduzqyb 333 15 vesicles vesicle NNS cord-023726-2fduzqyb 333 16 causes cause VBZ cord-023726-2fduzqyb 333 17 disassembly disassembly NN cord-023726-2fduzqyb 333 18 of of IN cord-023726-2fduzqyb 333 19 E2 E2 NNP cord-023726-2fduzqyb 333 20 / / SYM cord-023726-2fduzqyb 333 21 E1 E1 NNP cord-023726-2fduzqyb 333 22 heterodim heterodim NNP cord-023726-2fduzqyb 333 23 - - HYPH cord-023726-2fduzqyb 333 24 ers er NNS cord-023726-2fduzqyb 333 25 and and CC cord-023726-2fduzqyb 333 26 trimerization trimerization NN cord-023726-2fduzqyb 333 27 of of IN cord-023726-2fduzqyb 333 28 E1 E1 NNP cord-023726-2fduzqyb 333 29 to to TO cord-023726-2fduzqyb 333 30 form form VB cord-023726-2fduzqyb 333 31 homotrimers homotrimer NNS cord-023726-2fduzqyb 333 32 . . . cord-023726-2fduzqyb 334 1 The the DT cord-023726-2fduzqyb 334 2 fusion fusion NN cord-023726-2fduzqyb 334 3 peptide peptide NN cord-023726-2fduzqyb 334 4 is be VBZ cord-023726-2fduzqyb 334 5 exposed expose VBN cord-023726-2fduzqyb 334 6 and and CC cord-023726-2fduzqyb 334 7 penetrates penetrate VBZ cord-023726-2fduzqyb 334 8 the the DT cord-023726-2fduzqyb 334 9 target target NN cord-023726-2fduzqyb 334 10 bilayer bilayer NN cord-023726-2fduzqyb 334 11 of of IN cord-023726-2fduzqyb 334 12 the the DT cord-023726-2fduzqyb 334 13 host host NN cord-023726-2fduzqyb 334 14 endosomal endosomal NNP cord-023726-2fduzqyb 334 15 membrane membrane NN cord-023726-2fduzqyb 334 16 . . . cord-023726-2fduzqyb 335 1 Fusion fusion NN cord-023726-2fduzqyb 335 2 follows follow VBZ cord-023726-2fduzqyb 335 3 by by IN cord-023726-2fduzqyb 335 4 methods method NNS cord-023726-2fduzqyb 335 5 discussed discuss VBN cord-023726-2fduzqyb 335 6 in in IN cord-023726-2fduzqyb 335 7 Chapter chapter NN cord-023726-2fduzqyb 335 8 1 1 CD cord-023726-2fduzqyb 335 9 . . . cord-023726-2fduzqyb 336 1 Flaviviruses flavivirus NNS cord-023726-2fduzqyb 336 2 also also RB cord-023726-2fduzqyb 336 3 possess possess VBP cord-023726-2fduzqyb 336 4 a a DT cord-023726-2fduzqyb 336 5 regular regular JJ cord-023726-2fduzqyb 336 6 icosahedral icosahedral JJ cord-023726-2fduzqyb 336 7 structure structure NN cord-023726-2fduzqyb 336 8 ( ( -LRB- cord-023726-2fduzqyb 336 9 Fig Fig NNP cord-023726-2fduzqyb 336 10 . . . cord-023726-2fduzqyb 336 11 2.5 2.5 CD cord-023726-2fduzqyb 336 12 ) ) -RRB- cord-023726-2fduzqyb 336 13 that that WDT cord-023726-2fduzqyb 336 14 has have VBZ cord-023726-2fduzqyb 336 15 been be VBN cord-023726-2fduzqyb 336 16 solved solve VBN cord-023726-2fduzqyb 336 17 by by IN cord-023726-2fduzqyb 336 18 methods method NNS cord-023726-2fduzqyb 336 19 similar similar JJ cord-023726-2fduzqyb 336 20 to to IN cord-023726-2fduzqyb 336 21 those those DT cord-023726-2fduzqyb 336 22 used use VBN cord-023726-2fduzqyb 336 23 to to TO cord-023726-2fduzqyb 336 24 determine determine VB cord-023726-2fduzqyb 336 25 the the DT cord-023726-2fduzqyb 336 26 structure structure NN cord-023726-2fduzqyb 336 27 of of IN cord-023726-2fduzqyb 336 28 alphaviruses alphavirus NNS cord-023726-2fduzqyb 336 29 . . . cord-023726-2fduzqyb 337 1 The the DT cord-023726-2fduzqyb 337 2 structures structure NNS cord-023726-2fduzqyb 337 3 of of IN cord-023726-2fduzqyb 337 4 alphaviruses alphavirus NNS cord-023726-2fduzqyb 337 5 and and CC cord-023726-2fduzqyb 337 6 flaviviruses flavivirus NNS cord-023726-2fduzqyb 337 7 are be VBP cord-023726-2fduzqyb 337 8 related relate VBN cord-023726-2fduzqyb 337 9 and and CC cord-023726-2fduzqyb 337 10 have have VBP cord-023726-2fduzqyb 337 11 descended descend VBN cord-023726-2fduzqyb 337 12 from from IN cord-023726-2fduzqyb 337 13 a a DT cord-023726-2fduzqyb 337 14 common common JJ cord-023726-2fduzqyb 337 15 ancestral ancestral JJ cord-023726-2fduzqyb 337 16 structure structure NN cord-023726-2fduzqyb 337 17 . . . cord-023726-2fduzqyb 338 1 Like like IN cord-023726-2fduzqyb 338 2 alphaviruses alphaviruses NNP cord-023726-2fduzqyb 338 3 , , , cord-023726-2fduzqyb 338 4 flaviviruses flavivirus NNS cord-023726-2fduzqyb 338 5 produce produce VBP cord-023726-2fduzqyb 338 6 two two CD cord-023726-2fduzqyb 338 7 structural structural JJ cord-023726-2fduzqyb 338 8 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 338 9 , , , cord-023726-2fduzqyb 338 10 called call VBN cord-023726-2fduzqyb 338 11 E E NNP cord-023726-2fduzqyb 338 12 and and CC cord-023726-2fduzqyb 338 13 prM prm JJ cord-023726-2fduzqyb 338 14 ( ( -LRB- cord-023726-2fduzqyb 338 15 for for IN cord-023726-2fduzqyb 338 16 precursor precursor NN cord-023726-2fduzqyb 338 17 to to IN cord-023726-2fduzqyb 338 18 M M NNP cord-023726-2fduzqyb 338 19 ) ) -RRB- cord-023726-2fduzqyb 338 20 . . . cord-023726-2fduzqyb 339 1 E E NNP cord-023726-2fduzqyb 339 2 is be VBZ cord-023726-2fduzqyb 339 3 homologous homologous JJ cord-023726-2fduzqyb 339 4 to to IN cord-023726-2fduzqyb 339 5 E1 E1 NNP cord-023726-2fduzqyb 339 6 of of IN cord-023726-2fduzqyb 339 7 alphaviruses alphavirus NNS cord-023726-2fduzqyb 339 8 . . . cord-023726-2fduzqyb 340 1 Although although IN cord-023726-2fduzqyb 340 2 no no DT cord-023726-2fduzqyb 340 3 sequence sequence NN cord-023726-2fduzqyb 340 4 identity identity NN cord-023726-2fduzqyb 340 5 is be VBZ cord-023726-2fduzqyb 340 6 detectable detectable JJ cord-023726-2fduzqyb 340 7 , , , cord-023726-2fduzqyb 340 8 the the DT cord-023726-2fduzqyb 340 9 structures structure NNS cord-023726-2fduzqyb 340 10 of of IN cord-023726-2fduzqyb 340 11 the the DT cord-023726-2fduzqyb 340 12 two two CD cord-023726-2fduzqyb 340 13 proteins protein NNS cord-023726-2fduzqyb 340 14 are be VBP cord-023726-2fduzqyb 340 15 virtually virtually RB cord-023726-2fduzqyb 340 16 identical identical JJ cord-023726-2fduzqyb 340 17 and and CC cord-023726-2fduzqyb 340 18 are be VBP cord-023726-2fduzqyb 340 19 formed form VBN cord-023726-2fduzqyb 340 20 with with IN cord-023726-2fduzqyb 340 21 a a DT cord-023726-2fduzqyb 340 22 similar similar JJ cord-023726-2fduzqyb 340 23 fold fold NN cord-023726-2fduzqyb 340 24 ( ( -LRB- cord-023726-2fduzqyb 340 25 Fig fig NN cord-023726-2fduzqyb 340 26 . . . cord-023726-2fduzqyb 340 27 2.17 2.17 CD cord-023726-2fduzqyb 340 28 ) ) -RRB- cord-023726-2fduzqyb 340 29 . . . cord-023726-2fduzqyb 341 1 prM prM NNP cord-023726-2fduzqyb 341 2 and and CC cord-023726-2fduzqyb 341 3 E e NN cord-023726-2fduzqyb 341 4 form form VBP cord-023726-2fduzqyb 341 5 a a DT cord-023726-2fduzqyb 341 6 heterodimer heterodimer NN cord-023726-2fduzqyb 341 7 and and CC cord-023726-2fduzqyb 341 8 immature immature JJ cord-023726-2fduzqyb 341 9 particles particle NNS cord-023726-2fduzqyb 341 10 can can MD cord-023726-2fduzqyb 341 11 be be VB cord-023726-2fduzqyb 341 12 formed form VBN cord-023726-2fduzqyb 341 13 if if IN cord-023726-2fduzqyb 341 14 cleavage cleavage NN cord-023726-2fduzqyb 341 15 of of IN cord-023726-2fduzqyb 341 16 prM prm NN cord-023726-2fduzqyb 341 17 is be VBZ cord-023726-2fduzqyb 341 18 prevented prevent VBN cord-023726-2fduzqyb 341 19 . . . cord-023726-2fduzqyb 342 1 The the DT cord-023726-2fduzqyb 342 2 glycoprotein glycoprotein NN cord-023726-2fduzqyb 342 3 heterodimers heterodimer NNS cord-023726-2fduzqyb 342 4 in in IN cord-023726-2fduzqyb 342 5 these these DT cord-023726-2fduzqyb 342 6 immature immature JJ cord-023726-2fduzqyb 342 7 particles particle NNS cord-023726-2fduzqyb 342 8 trimerize trimerize NNP cord-023726-2fduzqyb 342 9 to to TO cord-023726-2fduzqyb 342 10 form form VB cord-023726-2fduzqyb 342 11 spikes spike NNS cord-023726-2fduzqyb 342 12 whose whose WP$ cord-023726-2fduzqyb 342 13 structure structure NN cord-023726-2fduzqyb 342 14 is be VBZ cord-023726-2fduzqyb 342 15 very very RB cord-023726-2fduzqyb 342 16 similar similar JJ cord-023726-2fduzqyb 342 17 to to IN cord-023726-2fduzqyb 342 18 the the DT cord-023726-2fduzqyb 342 19 spikes spike NNS cord-023726-2fduzqyb 342 20 of of IN cord-023726-2fduzqyb 342 21 alphaviruses alphavirus NNS cord-023726-2fduzqyb 342 22 ( ( -LRB- cord-023726-2fduzqyb 342 23 Fig Fig NNP cord-023726-2fduzqyb 342 24 . . . cord-023726-2fduzqyb 342 25 2.15B 2.15b CD cord-023726-2fduzqyb 342 26 ) ) -RRB- cord-023726-2fduzqyb 342 27 . . . cord-023726-2fduzqyb 343 1 The the DT cord-023726-2fduzqyb 343 2 arrangement arrangement NN cord-023726-2fduzqyb 343 3 of of IN cord-023726-2fduzqyb 343 4 the the DT cord-023726-2fduzqyb 343 5 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 343 6 on on IN cord-023726-2fduzqyb 343 7 the the DT cord-023726-2fduzqyb 343 8 immature immature JJ cord-023726-2fduzqyb 343 9 virus virus NN cord-023726-2fduzqyb 343 10 particle particle NN cord-023726-2fduzqyb 343 11 is be VBZ cord-023726-2fduzqyb 343 12 illustrated illustrate VBN cord-023726-2fduzqyb 343 13 in in IN cord-023726-2fduzqyb 343 14 Fig Fig NNP cord-023726-2fduzqyb 343 15 . . . cord-023726-2fduzqyb 344 1 2.18A 2.18a CD cord-023726-2fduzqyb 344 2 and and CC cord-023726-2fduzqyb 344 3 a a DT cord-023726-2fduzqyb 344 4 cryoEM cryoEM NNP cord-023726-2fduzqyb 344 5 reconstruction reconstruction NN cord-023726-2fduzqyb 344 6 that that WDT cord-023726-2fduzqyb 344 7 illustrates illustrate VBZ cord-023726-2fduzqyb 344 8 the the DT cord-023726-2fduzqyb 344 9 surface surface NN cord-023726-2fduzqyb 344 10 of of IN cord-023726-2fduzqyb 344 11 the the DT cord-023726-2fduzqyb 344 12 immature immature JJ cord-023726-2fduzqyb 344 13 dengue dengue NN cord-023726-2fduzqyb 344 14 virus virus NN cord-023726-2fduzqyb 344 15 particle particle NN cord-023726-2fduzqyb 344 16 is be VBZ cord-023726-2fduzqyb 344 17 shown show VBN cord-023726-2fduzqyb 344 18 in in IN cord-023726-2fduzqyb 344 19 Fig Fig NNP cord-023726-2fduzqyb 344 20 . . . cord-023726-2fduzqyb 345 1 2.18D 2.18D NNP cord-023726-2fduzqyb 345 2 . . . cord-023726-2fduzqyb 346 1 The the DT cord-023726-2fduzqyb 346 2 major major JJ cord-023726-2fduzqyb 346 3 differences difference NNS cord-023726-2fduzqyb 346 4 between between IN cord-023726-2fduzqyb 346 5 the the DT cord-023726-2fduzqyb 346 6 immature immature JJ cord-023726-2fduzqyb 346 7 flavivirus flavivirus JJ cord-023726-2fduzqyb 346 8 particle particle NN cord-023726-2fduzqyb 346 9 and and CC cord-023726-2fduzqyb 346 10 the the DT cord-023726-2fduzqyb 346 11 alphavirus alphavirus NNP cord-023726-2fduzqyb 346 12 particle particle NN cord-023726-2fduzqyb 346 13 are be VBP cord-023726-2fduzqyb 346 14 that that IN cord-023726-2fduzqyb 346 15 there there EX cord-023726-2fduzqyb 346 16 are be VBP cord-023726-2fduzqyb 346 17 180 180 CD cord-023726-2fduzqyb 346 18 copies copy NNS cord-023726-2fduzqyb 346 19 of of IN cord-023726-2fduzqyb 346 20 the the DT cord-023726-2fduzqyb 346 21 heterodimer heterodimer NN cord-023726-2fduzqyb 346 22 in in IN cord-023726-2fduzqyb 346 23 the the DT cord-023726-2fduzqyb 346 24 flavivirus flavivirus JJ cord-023726-2fduzqyb 346 25 particle particle NN cord-023726-2fduzqyb 346 26 arranged arrange VBN cord-023726-2fduzqyb 346 27 in in IN cord-023726-2fduzqyb 346 28 a a DT cord-023726-2fduzqyb 346 29 T=3 T=3 NNP cord-023726-2fduzqyb 346 30 icosahedral icosahedral JJ cord-023726-2fduzqyb 346 31 structure structure NN cord-023726-2fduzqyb 346 32 rather rather RB cord-023726-2fduzqyb 346 33 than than IN cord-023726-2fduzqyb 346 34 240 240 CD cord-023726-2fduzqyb 346 35 heterodimers heterodimer NNS cord-023726-2fduzqyb 346 36 arranged arrange VBN cord-023726-2fduzqyb 346 37 in in IN cord-023726-2fduzqyb 346 38 a a DT cord-023726-2fduzqyb 346 39 T=4 T=4 NNP cord-023726-2fduzqyb 346 40 structure structure NN cord-023726-2fduzqyb 346 41 in in IN cord-023726-2fduzqyb 346 42 alphaviruses alphaviruses NNP cord-023726-2fduzqyb 346 43 ; ; : cord-023726-2fduzqyb 346 44 that that IN cord-023726-2fduzqyb 346 45 prM prm NN cord-023726-2fduzqyb 346 46 is be VBZ cord-023726-2fduzqyb 346 47 a a DT cord-023726-2fduzqyb 346 48 smaller small JJR cord-023726-2fduzqyb 346 49 molecule molecule NN cord-023726-2fduzqyb 346 50 than than IN cord-023726-2fduzqyb 346 51 PE2 PE2 NNP cord-023726-2fduzqyb 346 52 so so IN cord-023726-2fduzqyb 346 53 that that IN cord-023726-2fduzqyb 346 54 in in IN cord-023726-2fduzqyb 346 55 the the DT cord-023726-2fduzqyb 346 56 flavivirus flavivirus JJ cord-023726-2fduzqyb 346 57 spike spike NN cord-023726-2fduzqyb 346 58 there there EX cord-023726-2fduzqyb 346 59 is be VBZ cord-023726-2fduzqyb 346 60 but but CC cord-023726-2fduzqyb 346 61 a a DT cord-023726-2fduzqyb 346 62 thin thin JJ cord-023726-2fduzqyb 346 63 trace trace NN cord-023726-2fduzqyb 346 64 of of IN cord-023726-2fduzqyb 346 65 density density NN cord-023726-2fduzqyb 346 66 that that WDT cord-023726-2fduzqyb 346 67 projects project VBZ cord-023726-2fduzqyb 346 68 downward downward RB cord-023726-2fduzqyb 346 69 , , , cord-023726-2fduzqyb 346 70 parallel parallel JJ cord-023726-2fduzqyb 346 71 to to IN cord-023726-2fduzqyb 346 72 E e NN cord-023726-2fduzqyb 346 73 , , , cord-023726-2fduzqyb 346 74 from from IN cord-023726-2fduzqyb 346 75 the the DT cord-023726-2fduzqyb 346 76 cap cap NN cord-023726-2fduzqyb 346 77 that that WDT cord-023726-2fduzqyb 346 78 shields shield VBZ cord-023726-2fduzqyb 346 79 the the DT cord-023726-2fduzqyb 346 80 fusion fusion NN cord-023726-2fduzqyb 346 81 peptide peptide NN cord-023726-2fduzqyb 346 82 ( ( -LRB- cord-023726-2fduzqyb 346 83 Fig Fig NNP cord-023726-2fduzqyb 346 84 . . . cord-023726-2fduzqyb 346 85 2.15B 2.15b CD cord-023726-2fduzqyb 346 86 ) ) -RRB- cord-023726-2fduzqyb 346 87 rather rather RB cord-023726-2fduzqyb 346 88 than than IN cord-023726-2fduzqyb 346 89 a a DT cord-023726-2fduzqyb 346 90 substantial substantial JJ cord-023726-2fduzqyb 346 91 trace trace NN cord-023726-2fduzqyb 346 92 of of IN cord-023726-2fduzqyb 346 93 density density NN cord-023726-2fduzqyb 346 94 in in IN cord-023726-2fduzqyb 346 95 the the DT cord-023726-2fduzqyb 346 96 alphavirus alphavirus NNP cord-023726-2fduzqyb 346 97 spike spike NN cord-023726-2fduzqyb 346 98 ( ( -LRB- cord-023726-2fduzqyb 346 99 Fig fig NN cord-023726-2fduzqyb 346 100 . . . cord-023726-2fduzqyb 346 101 2.15A 2.15a LS cord-023726-2fduzqyb 346 102 ) ) -RRB- cord-023726-2fduzqyb 346 103 ; ; : cord-023726-2fduzqyb 346 104 and and CC cord-023726-2fduzqyb 346 105 that that IN cord-023726-2fduzqyb 346 106 the the DT cord-023726-2fduzqyb 346 107 C c NN cord-023726-2fduzqyb 346 108 - - HYPH cord-023726-2fduzqyb 346 109 terminal terminal NN cord-023726-2fduzqyb 346 110 regions region NNS cord-023726-2fduzqyb 346 111 of of IN cord-023726-2fduzqyb 346 112 prM prm JJ cord-023726-2fduzqyb 346 113 and and CC cord-023726-2fduzqyb 346 114 E E NNS cord-023726-2fduzqyb 346 115 that that WDT cord-023726-2fduzqyb 346 116 enter enter VBP cord-023726-2fduzqyb 346 117 the the DT cord-023726-2fduzqyb 346 118 membrane membrane NN cord-023726-2fduzqyb 346 119 do do VBP cord-023726-2fduzqyb 346 120 so so RB cord-023726-2fduzqyb 346 121 independently independently RB cord-023726-2fduzqyb 346 122 and and CC cord-023726-2fduzqyb 346 123 do do VBP cord-023726-2fduzqyb 346 124 not not RB cord-023726-2fduzqyb 346 125 emerge emerge VB cord-023726-2fduzqyb 346 126 from from IN cord-023726-2fduzqyb 346 127 the the DT cord-023726-2fduzqyb 346 128 internal internal JJ cord-023726-2fduzqyb 346 129 side side NN cord-023726-2fduzqyb 346 130 of of IN cord-023726-2fduzqyb 346 131 the the DT cord-023726-2fduzqyb 346 132 membrane membrane NN cord-023726-2fduzqyb 346 133 ( ( -LRB- cord-023726-2fduzqyb 346 134 illustrated illustrate VBN cord-023726-2fduzqyb 346 135 in in IN cord-023726-2fduzqyb 346 136 Fig Fig NNP cord-023726-2fduzqyb 346 137 . . . cord-023726-2fduzqyb 346 138 2.19B 2.19b LS cord-023726-2fduzqyb 346 139 ) ) -RRB- cord-023726-2fduzqyb 346 140 , , , cord-023726-2fduzqyb 346 141 unlike unlike IN cord-023726-2fduzqyb 346 142 the the DT cord-023726-2fduzqyb 346 143 alphavirus alphavirus NNP cord-023726-2fduzqyb 346 144 membrane membrane NN cord-023726-2fduzqyb 346 145 spanning spanning NN cord-023726-2fduzqyb 346 146 regions region NNS cord-023726-2fduzqyb 346 147 ( ( -LRB- cord-023726-2fduzqyb 346 148 Fig Fig NNP cord-023726-2fduzqyb 346 149 . . . cord-023726-2fduzqyb 346 150 2.16 2.16 CD cord-023726-2fduzqyb 346 151 ) ) -RRB- cord-023726-2fduzqyb 346 152 . . . cord-023726-2fduzqyb 347 1 There there EX cord-023726-2fduzqyb 347 2 is be VBZ cord-023726-2fduzqyb 347 3 no no DT cord-023726-2fduzqyb 347 4 evidence evidence NN cord-023726-2fduzqyb 347 5 that that IN cord-023726-2fduzqyb 347 6 the the DT cord-023726-2fduzqyb 347 7 membrane membrane NN cord-023726-2fduzqyb 347 8 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 347 9 interact interact VBP cord-023726-2fduzqyb 347 10 with with IN cord-023726-2fduzqyb 347 11 the the DT cord-023726-2fduzqyb 347 12 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 347 13 in in IN cord-023726-2fduzqyb 347 14 flaviviruses flavivirus NNS cord-023726-2fduzqyb 347 15 , , , cord-023726-2fduzqyb 347 16 and and CC cord-023726-2fduzqyb 347 17 the the DT cord-023726-2fduzqyb 347 18 flavivirus flavivirus NNP cord-023726-2fduzqyb 347 19 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 347 20 , , , cord-023726-2fduzqyb 347 21 assuming assume VBG cord-023726-2fduzqyb 347 22 it -PRON- PRP cord-023726-2fduzqyb 347 23 is be VBZ cord-023726-2fduzqyb 347 24 a a DT cord-023726-2fduzqyb 347 25 regular regular JJ cord-023726-2fduzqyb 347 26 icosahedral icosahedral JJ cord-023726-2fduzqyb 347 27 structure structure NN cord-023726-2fduzqyb 347 28 , , , cord-023726-2fduzqyb 347 29 is be VBZ cord-023726-2fduzqyb 347 30 not not RB cord-023726-2fduzqyb 347 31 coordinated coordinate VBN cord-023726-2fduzqyb 347 32 with with IN cord-023726-2fduzqyb 347 33 the the DT cord-023726-2fduzqyb 347 34 icosahedral icosahedral JJ cord-023726-2fduzqyb 347 35 structure structure NN cord-023726-2fduzqyb 347 36 formed form VBN cord-023726-2fduzqyb 347 37 by by IN cord-023726-2fduzqyb 347 38 the the DT cord-023726-2fduzqyb 347 39 spikes spike NNS cord-023726-2fduzqyb 347 40 , , , cord-023726-2fduzqyb 347 41 which which WDT cord-023726-2fduzqyb 347 42 is be VBZ cord-023726-2fduzqyb 347 43 again again RB cord-023726-2fduzqyb 347 44 different different JJ cord-023726-2fduzqyb 347 45 from from IN cord-023726-2fduzqyb 347 46 alphaviruses alphavirus NNS cord-023726-2fduzqyb 347 47 where where WRB cord-023726-2fduzqyb 347 48 the the DT cord-023726-2fduzqyb 347 49 C C NNP cord-023726-2fduzqyb 347 50 - - HYPH cord-023726-2fduzqyb 347 51 terminal terminal NN cord-023726-2fduzqyb 347 52 domain domain NN cord-023726-2fduzqyb 347 53 of of IN cord-023726-2fduzqyb 347 54 PE2 PE2 NNP cord-023726-2fduzqyb 347 55 interacts interact VBZ cord-023726-2fduzqyb 347 56 with with IN cord-023726-2fduzqyb 347 57 the the DT cord-023726-2fduzqyb 347 58 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 347 59 . . . cord-023726-2fduzqyb 348 1 Following follow VBG cord-023726-2fduzqyb 348 2 cleavage cleavage NN cord-023726-2fduzqyb 348 3 of of IN cord-023726-2fduzqyb 348 4 prM prm NN cord-023726-2fduzqyb 348 5 by by IN cord-023726-2fduzqyb 348 6 furin furin NN cord-023726-2fduzqyb 348 7 to to TO cord-023726-2fduzqyb 348 8 form form VB cord-023726-2fduzqyb 348 9 M M NNP cord-023726-2fduzqyb 348 10 , , , cord-023726-2fduzqyb 348 11 there there EX cord-023726-2fduzqyb 348 12 is be VBZ cord-023726-2fduzqyb 348 13 a a DT cord-023726-2fduzqyb 348 14 dramatic dramatic JJ cord-023726-2fduzqyb 348 15 rearrangement rearrangement NN cord-023726-2fduzqyb 348 16 of of IN cord-023726-2fduzqyb 348 17 the the DT cord-023726-2fduzqyb 348 18 flavivirus flavivirus JJ cord-023726-2fduzqyb 348 19 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 348 20 such such JJ cord-023726-2fduzqyb 348 21 that that IN cord-023726-2fduzqyb 348 22 the the DT cord-023726-2fduzqyb 348 23 final final JJ cord-023726-2fduzqyb 348 24 virion virion NN cord-023726-2fduzqyb 348 25 structure structure NN cord-023726-2fduzqyb 348 26 is be VBZ cord-023726-2fduzqyb 348 27 very very RB cord-023726-2fduzqyb 348 28 different different JJ cord-023726-2fduzqyb 348 29 from from IN cord-023726-2fduzqyb 348 30 the the DT cord-023726-2fduzqyb 348 31 alphavirus alphavirus NNP cord-023726-2fduzqyb 348 32 structure structure NN cord-023726-2fduzqyb 348 33 . . . cord-023726-2fduzqyb 349 1 The the DT cord-023726-2fduzqyb 349 2 heterodimers heterodimer NNS cord-023726-2fduzqyb 349 3 dissociate dissociate VBP cord-023726-2fduzqyb 349 4 and and CC cord-023726-2fduzqyb 349 5 E E NNS cord-023726-2fduzqyb 349 6 - - HYPH cord-023726-2fduzqyb 349 7 E e JJ cord-023726-2fduzqyb 349 8 homodimers homodimer NNS cord-023726-2fduzqyb 349 9 are be VBP cord-023726-2fduzqyb 349 10 formed form VBN cord-023726-2fduzqyb 349 11 that that DT cord-023726-2fduzqyb 349 12 collapse collapse NN cord-023726-2fduzqyb 349 13 over over IN cord-023726-2fduzqyb 349 14 the the DT cord-023726-2fduzqyb 349 15 lipid lipid NN cord-023726-2fduzqyb 349 16 bilayer bilayer NN cord-023726-2fduzqyb 349 17 ( ( -LRB- cord-023726-2fduzqyb 349 18 Fig Fig NNP cord-023726-2fduzqyb 349 19 . . . cord-023726-2fduzqyb 349 20 2.19 2.19 CD cord-023726-2fduzqyb 349 21 ) ) -RRB- cord-023726-2fduzqyb 349 22 . . . cord-023726-2fduzqyb 350 1 The the DT cord-023726-2fduzqyb 350 2 E e NN cord-023726-2fduzqyb 350 3 - - HYPH cord-023726-2fduzqyb 350 4 E e JJ cord-023726-2fduzqyb 350 5 homodimers homodimer NNS cord-023726-2fduzqyb 350 6 occur occur VBP cord-023726-2fduzqyb 350 7 in in IN cord-023726-2fduzqyb 350 8 two two CD cord-023726-2fduzqyb 350 9 totally totally RB cord-023726-2fduzqyb 350 10 different different JJ cord-023726-2fduzqyb 350 11 environments environment NNS cord-023726-2fduzqyb 350 12 , , , cord-023726-2fduzqyb 350 13 either either CC cord-023726-2fduzqyb 350 14 perpendicular perpendicular JJ cord-023726-2fduzqyb 350 15 to to IN cord-023726-2fduzqyb 350 16 the the DT cord-023726-2fduzqyb 350 17 twofold twofold JJ cord-023726-2fduzqyb 350 18 axis axis NN cord-023726-2fduzqyb 350 19 where where WRB cord-023726-2fduzqyb 350 20 they -PRON- PRP cord-023726-2fduzqyb 350 21 interact interact VBP cord-023726-2fduzqyb 350 22 with with IN cord-023726-2fduzqyb 350 23 homodimers homodimer NNS cord-023726-2fduzqyb 350 24 in in IN cord-023726-2fduzqyb 350 25 sideto sideto JJ cord-023726-2fduzqyb 350 26 - - HYPH cord-023726-2fduzqyb 350 27 side side NN cord-023726-2fduzqyb 350 28 interactions interaction NNS cord-023726-2fduzqyb 350 29 , , , cord-023726-2fduzqyb 350 30 forming form VBG cord-023726-2fduzqyb 350 31 a a DT cord-023726-2fduzqyb 350 32 herringbone herringbone NN cord-023726-2fduzqyb 350 33 pattern pattern NN cord-023726-2fduzqyb 350 34 , , , cord-023726-2fduzqyb 350 35 or or CC cord-023726-2fduzqyb 350 36 parallel parallel JJ cord-023726-2fduzqyb 350 37 to to IN cord-023726-2fduzqyb 350 38 a a DT cord-023726-2fduzqyb 350 39 twofold twofold JJ cord-023726-2fduzqyb 350 40 axis axis NN cord-023726-2fduzqyb 350 41 where where WRB cord-023726-2fduzqyb 350 42 they -PRON- PRP cord-023726-2fduzqyb 350 43 interact interact VBP cord-023726-2fduzqyb 350 44 at at IN cord-023726-2fduzqyb 350 45 fivefold fivefold RB cord-023726-2fduzqyb 350 46 and and CC cord-023726-2fduzqyb 350 47 threefold threefold JJ cord-023726-2fduzqyb 350 48 axes axis NNS cord-023726-2fduzqyb 350 49 ( ( -LRB- cord-023726-2fduzqyb 350 50 Fig Fig NNP cord-023726-2fduzqyb 350 51 . . . cord-023726-2fduzqyb 350 52 2.18B 2.18b CD cord-023726-2fduzqyb 350 53 ) ) -RRB- cord-023726-2fduzqyb 350 54 . . . cord-023726-2fduzqyb 351 1 A a DT cord-023726-2fduzqyb 351 2 comparison comparison NN cord-023726-2fduzqyb 351 3 of of IN cord-023726-2fduzqyb 351 4 the the DT cord-023726-2fduzqyb 351 5 immature immature JJ cord-023726-2fduzqyb 351 6 flavivirus flavivirus JJ cord-023726-2fduzqyb 351 7 particle particle NN cord-023726-2fduzqyb 351 8 , , , cord-023726-2fduzqyb 351 9 T398 T398 NNPS cord-023726-2fduzqyb 351 10 FIGURE figure NN cord-023726-2fduzqyb 351 11 2.16 2.16 CD cord-023726-2fduzqyb 352 1 The the DT cord-023726-2fduzqyb 352 2 E1 e1 NN cord-023726-2fduzqyb 352 3 and and CC cord-023726-2fduzqyb 352 4 E2 E2 NNP cord-023726-2fduzqyb 352 5 transmembrane transmembrane NN cord-023726-2fduzqyb 352 6 helices helix NNS cord-023726-2fduzqyb 352 7 of of IN cord-023726-2fduzqyb 352 8 Sindbis Sindbis NNP cord-023726-2fduzqyb 352 9 ( ( -LRB- cord-023726-2fduzqyb 352 10 an an DT cord-023726-2fduzqyb 352 11 alphavirus alphavirus NNP cord-023726-2fduzqyb 352 12 ) ) -RRB- cord-023726-2fduzqyb 352 13 determined determine VBN cord-023726-2fduzqyb 352 14 from from IN cord-023726-2fduzqyb 352 15 a a DT cord-023726-2fduzqyb 352 16 9Å 9å NN cord-023726-2fduzqyb 352 17 resolution resolution NN cord-023726-2fduzqyb 352 18 cryoelectron cryoelectron NNP cord-023726-2fduzqyb 352 19 microscopy microscopy NNP cord-023726-2fduzqyb 352 20 reconstruction reconstruction NN cord-023726-2fduzqyb 352 21 . . . cord-023726-2fduzqyb 353 1 Shown show VBN cord-023726-2fduzqyb 353 2 are be VBP cord-023726-2fduzqyb 353 3 E1 e1 NN cord-023726-2fduzqyb 353 4 residues residue NNS cord-023726-2fduzqyb 353 5 from from IN cord-023726-2fduzqyb 353 6 409 409 CD cord-023726-2fduzqyb 353 7 to to IN cord-023726-2fduzqyb 353 8 439 439 CD cord-023726-2fduzqyb 353 9 and and CC cord-023726-2fduzqyb 353 10 E2 E2 NNP cord-023726-2fduzqyb 353 11 residues residue VBZ cord-023726-2fduzqyb 353 12 363 363 CD cord-023726-2fduzqyb 353 13 to to IN cord-023726-2fduzqyb 353 14 398 398 CD cord-023726-2fduzqyb 353 15 fitted fit VBN cord-023726-2fduzqyb 353 16 into into IN cord-023726-2fduzqyb 353 17 the the DT cord-023726-2fduzqyb 353 18 transmembrane transmembrane NN cord-023726-2fduzqyb 353 19 density density NN cord-023726-2fduzqyb 353 20 . . . cord-023726-2fduzqyb 354 1 This this DT cord-023726-2fduzqyb 354 2 is be VBZ cord-023726-2fduzqyb 354 3 Figure figure NN cord-023726-2fduzqyb 354 4 6 6 CD cord-023726-2fduzqyb 354 5 from from IN cord-023726-2fduzqyb 354 6 Mukhopadhyay Mukhopadhyay NNP cord-023726-2fduzqyb 354 7 et et NNP cord-023726-2fduzqyb 354 8 al al NNP cord-023726-2fduzqyb 354 9 . . . cord-023726-2fduzqyb 355 1 ( ( -LRB- cord-023726-2fduzqyb 355 2 2006 2006 CD cord-023726-2fduzqyb 355 3 ) ) -RRB- cord-023726-2fduzqyb 355 4 , , , cord-023726-2fduzqyb 355 5 reprinted reprint VBN cord-023726-2fduzqyb 355 6 with with IN cord-023726-2fduzqyb 355 7 permission permission NN cord-023726-2fduzqyb 355 8 . . . cord-023726-2fduzqyb 356 1 the the DT cord-023726-2fduzqyb 356 2 mature mature JJ cord-023726-2fduzqyb 356 3 flavivirus flavivirus JJ cord-023726-2fduzqyb 356 4 particle particle NN cord-023726-2fduzqyb 356 5 , , , cord-023726-2fduzqyb 356 6 and and CC cord-023726-2fduzqyb 356 7 the the DT cord-023726-2fduzqyb 356 8 alphavirus alphavirus NNP cord-023726-2fduzqyb 356 9 particle particle NN cord-023726-2fduzqyb 356 10 is be VBZ cord-023726-2fduzqyb 356 11 shown show VBN cord-023726-2fduzqyb 356 12 in in IN cord-023726-2fduzqyb 356 13 Fig Fig NNP cord-023726-2fduzqyb 356 14 . . . cord-023726-2fduzqyb 357 1 2.18 2.18 CD cord-023726-2fduzqyb 357 2 . . . cord-023726-2fduzqyb 358 1 The the DT cord-023726-2fduzqyb 358 2 mature mature JJ cord-023726-2fduzqyb 358 3 flavivirus flavivirus NN cord-023726-2fduzqyb 358 4 is be VBZ cord-023726-2fduzqyb 358 5 smooth smooth JJ cord-023726-2fduzqyb 358 6 , , , cord-023726-2fduzqyb 358 7 with with IN cord-023726-2fduzqyb 358 8 no no DT cord-023726-2fduzqyb 358 9 surface surface NN cord-023726-2fduzqyb 358 10 projections projection NNS cord-023726-2fduzqyb 358 11 , , , cord-023726-2fduzqyb 358 12 and and CC cord-023726-2fduzqyb 358 13 is be VBZ cord-023726-2fduzqyb 358 14 50 50 CD cord-023726-2fduzqyb 358 15 nm nm NN cord-023726-2fduzqyb 358 16 in in IN cord-023726-2fduzqyb 358 17 diameter diameter NN cord-023726-2fduzqyb 359 1 ( ( -LRB- cord-023726-2fduzqyb 359 2 Fig Fig NNP cord-023726-2fduzqyb 359 3 . . . cord-023726-2fduzqyb 359 4 2.18E 2.18e CD cord-023726-2fduzqyb 359 5 ) ) -RRB- cord-023726-2fduzqyb 359 6 . . . cord-023726-2fduzqyb 360 1 The the DT cord-023726-2fduzqyb 360 2 immature immature JJ cord-023726-2fduzqyb 360 3 particle particle NN cord-023726-2fduzqyb 360 4 is be VBZ cord-023726-2fduzqyb 360 5 ragged rag VBN cord-023726-2fduzqyb 360 6 in in IN cord-023726-2fduzqyb 360 7 appearance appearance NN cord-023726-2fduzqyb 360 8 and and CC cord-023726-2fduzqyb 360 9 is be VBZ cord-023726-2fduzqyb 360 10 60 60 CD cord-023726-2fduzqyb 360 11 nm nm NN cord-023726-2fduzqyb 360 12 in in IN cord-023726-2fduzqyb 360 13 diameter diameter NN cord-023726-2fduzqyb 361 1 ( ( -LRB- cord-023726-2fduzqyb 361 2 Fig Fig NNP cord-023726-2fduzqyb 361 3 . . . cord-023726-2fduzqyb 361 4 2.18D 2.18d CD cord-023726-2fduzqyb 361 5 ) ) -RRB- cord-023726-2fduzqyb 361 6 . . . cord-023726-2fduzqyb 362 1 The the DT cord-023726-2fduzqyb 362 2 alphavirus alphavirus NNP cord-023726-2fduzqyb 362 3 virion virion NN cord-023726-2fduzqyb 362 4 shows show VBZ cord-023726-2fduzqyb 362 5 conspicuous conspicuous JJ cord-023726-2fduzqyb 362 6 spikes spike NNS cord-023726-2fduzqyb 362 7 and and CC cord-023726-2fduzqyb 362 8 is be VBZ cord-023726-2fduzqyb 362 9 70 70 CD cord-023726-2fduzqyb 362 10 nm nm NN cord-023726-2fduzqyb 362 11 in in IN cord-023726-2fduzqyb 362 12 diameter diameter NN cord-023726-2fduzqyb 363 1 ( ( -LRB- cord-023726-2fduzqyb 363 2 Fig Fig NNP cord-023726-2fduzqyb 363 3 . . . cord-023726-2fduzqyb 363 4 2.18F 2.18f CD cord-023726-2fduzqyb 363 5 ) ) -RRB- cord-023726-2fduzqyb 363 6 . . . cord-023726-2fduzqyb 364 1 The the DT cord-023726-2fduzqyb 364 2 arrangement arrangement NN cord-023726-2fduzqyb 364 3 of of IN cord-023726-2fduzqyb 364 4 E E NNP cord-023726-2fduzqyb 364 5 or or CC cord-023726-2fduzqyb 364 6 E1 e1 NN cord-023726-2fduzqyb 364 7 in in IN cord-023726-2fduzqyb 364 8 the the DT cord-023726-2fduzqyb 364 9 three three CD cord-023726-2fduzqyb 364 10 particles particle NNS cord-023726-2fduzqyb 364 11 is be VBZ cord-023726-2fduzqyb 364 12 also also RB cord-023726-2fduzqyb 364 13 shown show VBN cord-023726-2fduzqyb 364 14 ( ( -LRB- cord-023726-2fduzqyb 364 15 Figs fig NNS cord-023726-2fduzqyb 364 16 . . . cord-023726-2fduzqyb 365 1 2.18A 2.18a CD cord-023726-2fduzqyb 365 2 , , , cord-023726-2fduzqyb 365 3 B b NN cord-023726-2fduzqyb 365 4 , , , cord-023726-2fduzqyb 365 5 C C NNP cord-023726-2fduzqyb 365 6 ) ) -RRB- cord-023726-2fduzqyb 365 7 , , , cord-023726-2fduzqyb 365 8 illustrating illustrate VBG cord-023726-2fduzqyb 365 9 the the DT cord-023726-2fduzqyb 365 10 differences difference NNS cord-023726-2fduzqyb 365 11 in in IN cord-023726-2fduzqyb 365 12 their -PRON- PRP$ cord-023726-2fduzqyb 365 13 arrangement arrangement NN cord-023726-2fduzqyb 365 14 . . . cord-023726-2fduzqyb 366 1 Entry entry NN cord-023726-2fduzqyb 366 2 of of IN cord-023726-2fduzqyb 366 3 flaviviruses flavivirus NNS cord-023726-2fduzqyb 366 4 follows follow VBZ cord-023726-2fduzqyb 366 5 pathways pathway NNS cord-023726-2fduzqyb 366 6 similar similar JJ cord-023726-2fduzqyb 366 7 to to IN cord-023726-2fduzqyb 366 8 those those DT cord-023726-2fduzqyb 366 9 used use VBN cord-023726-2fduzqyb 366 10 by by IN cord-023726-2fduzqyb 366 11 alphaviruses alphavirus NNS cord-023726-2fduzqyb 366 12 . . . cord-023726-2fduzqyb 367 1 The the DT cord-023726-2fduzqyb 367 2 acidic acidic JJ cord-023726-2fduzqyb 367 3 pH ph NN cord-023726-2fduzqyb 367 4 of of IN cord-023726-2fduzqyb 367 5 the the DT cord-023726-2fduzqyb 367 6 endosome endosome NN cord-023726-2fduzqyb 367 7 causes cause VBZ cord-023726-2fduzqyb 367 8 the the DT cord-023726-2fduzqyb 367 9 E e NN cord-023726-2fduzqyb 367 10 - - HYPH cord-023726-2fduzqyb 367 11 E e JJ cord-023726-2fduzqyb 367 12 homodimers homodimer NNS cord-023726-2fduzqyb 367 13 to to TO cord-023726-2fduzqyb 367 14 reorganize reorganize VB cord-023726-2fduzqyb 367 15 to to TO cord-023726-2fduzqyb 367 16 form form VB cord-023726-2fduzqyb 367 17 E E NNP cord-023726-2fduzqyb 367 18 homotrimers homotrimer NNS cord-023726-2fduzqyb 367 19 . . . cord-023726-2fduzqyb 368 1 These these DT cord-023726-2fduzqyb 368 2 trimers trimer NNS cord-023726-2fduzqyb 368 3 must must MD cord-023726-2fduzqyb 368 4 reorient reorient VB cord-023726-2fduzqyb 368 5 so so IN cord-023726-2fduzqyb 368 6 that that IN cord-023726-2fduzqyb 368 7 the the DT cord-023726-2fduzqyb 368 8 exposed expose VBN cord-023726-2fduzqyb 368 9 fusion fusion NN cord-023726-2fduzqyb 368 10 peptide peptide NN cord-023726-2fduzqyb 368 11 is be VBZ cord-023726-2fduzqyb 368 12 projected project VBN cord-023726-2fduzqyb 368 13 upwards upwards RB cord-023726-2fduzqyb 368 14 where where WRB cord-023726-2fduzqyb 368 15 it -PRON- PRP cord-023726-2fduzqyb 368 16 penetrates penetrate VBZ cord-023726-2fduzqyb 368 17 the the DT cord-023726-2fduzqyb 368 18 host host NN cord-023726-2fduzqyb 368 19 membrane membrane NN cord-023726-2fduzqyb 368 20 . . . cord-023726-2fduzqyb 369 1 The the DT cord-023726-2fduzqyb 369 2 arteriviruses arteriviruse NNS cord-023726-2fduzqyb 369 3 possess possess VBP cord-023726-2fduzqyb 369 4 icosahedral icosahedral JJ cord-023726-2fduzqyb 369 5 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 369 6 , , , cord-023726-2fduzqyb 369 7 but but CC cord-023726-2fduzqyb 369 8 the the DT cord-023726-2fduzqyb 369 9 mature mature JJ cord-023726-2fduzqyb 369 10 virion virion NN cord-023726-2fduzqyb 369 11 does do VBZ cord-023726-2fduzqyb 369 12 not not RB cord-023726-2fduzqyb 369 13 appear appear VB cord-023726-2fduzqyb 369 14 to to TO cord-023726-2fduzqyb 369 15 be be VB cord-023726-2fduzqyb 369 16 regular regular JJ cord-023726-2fduzqyb 369 17 in in IN cord-023726-2fduzqyb 369 18 structure structure NN cord-023726-2fduzqyb 369 19 . . . cord-023726-2fduzqyb 370 1 Detailed detailed JJ cord-023726-2fduzqyb 370 2 structures structure NNS cord-023726-2fduzqyb 370 3 of of IN cord-023726-2fduzqyb 370 4 these these DT cord-023726-2fduzqyb 370 5 particles particle NNS cord-023726-2fduzqyb 370 6 are be VBP cord-023726-2fduzqyb 370 7 not not RB cord-023726-2fduzqyb 370 8 available available JJ cord-023726-2fduzqyb 370 9 . . . cord-023726-2fduzqyb 371 1 The the DT cord-023726-2fduzqyb 371 2 herpesviruses herpesviruse NNS cord-023726-2fduzqyb 371 3 are be VBP cord-023726-2fduzqyb 371 4 large large JJ cord-023726-2fduzqyb 371 5 DNA dna NN cord-023726-2fduzqyb 371 6 viruses virus NNS cord-023726-2fduzqyb 371 7 that that WDT cord-023726-2fduzqyb 371 8 have have VBP cord-023726-2fduzqyb 371 9 a a DT cord-023726-2fduzqyb 371 10 T=16 T=16 NNP cord-023726-2fduzqyb 371 11 icosahedral icosahedral JJ cord-023726-2fduzqyb 371 12 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 371 13 ( ( -LRB- cord-023726-2fduzqyb 371 14 Fig Fig NNP cord-023726-2fduzqyb 371 15 . . . cord-023726-2fduzqyb 371 16 2.5 2.5 CD cord-023726-2fduzqyb 371 17 ) ) -RRB- cord-023726-2fduzqyb 371 18 . . . cord-023726-2fduzqyb 372 1 A a DT cord-023726-2fduzqyb 372 2 schematic schematic JJ cord-023726-2fduzqyb 372 3 diagram diagram NN cord-023726-2fduzqyb 372 4 of of IN cord-023726-2fduzqyb 372 5 an an DT cord-023726-2fduzqyb 372 6 intact intact JJ cord-023726-2fduzqyb 372 7 herpesvirion herpesvirion NN cord-023726-2fduzqyb 372 8 is be VBZ cord-023726-2fduzqyb 372 9 shown show VBN cord-023726-2fduzqyb 372 10 in in IN cord-023726-2fduzqyb 372 11 Fig Fig NNP cord-023726-2fduzqyb 372 12 . . . cord-023726-2fduzqyb 373 1 2.20A 2.20a LS cord-023726-2fduzqyb 373 2 . . . cord-023726-2fduzqyb 374 1 Underneath underneath IN cord-023726-2fduzqyb 374 2 the the DT cord-023726-2fduzqyb 374 3 envelope envelope NN cord-023726-2fduzqyb 374 4 is be VBZ cord-023726-2fduzqyb 374 5 a a DT cord-023726-2fduzqyb 374 6 protein protein NN cord-023726-2fduzqyb 374 7 layer layer NN cord-023726-2fduzqyb 374 8 called call VBN cord-023726-2fduzqyb 374 9 the the DT cord-023726-2fduzqyb 374 10 tegument tegument NN cord-023726-2fduzqyb 374 11 . . . cord-023726-2fduzqyb 375 1 The the DT cord-023726-2fduzqyb 375 2 tegument tegument NN cord-023726-2fduzqyb 375 3 does do VBZ cord-023726-2fduzqyb 375 4 not not RB cord-023726-2fduzqyb 375 5 have have VB cord-023726-2fduzqyb 375 6 a a DT cord-023726-2fduzqyb 375 7 uniform uniform JJ cord-023726-2fduzqyb 375 8 thickness thickness NN cord-023726-2fduzqyb 375 9 , , , cord-023726-2fduzqyb 375 10 and and CC cord-023726-2fduzqyb 375 11 thus thus RB cord-023726-2fduzqyb 375 12 the the DT cord-023726-2fduzqyb 375 13 virion virion NN cord-023726-2fduzqyb 375 14 is be VBZ cord-023726-2fduzqyb 375 15 not not RB cord-023726-2fduzqyb 375 16 uniform uniform JJ cord-023726-2fduzqyb 375 17 . . . cord-023726-2fduzqyb 376 1 Two two CD cord-023726-2fduzqyb 376 2 electron electron NN cord-023726-2fduzqyb 376 3 micrographs micrograph NNS cord-023726-2fduzqyb 376 4 of of IN cord-023726-2fduzqyb 376 5 herpesvirions herpesvirion NNS cord-023726-2fduzqyb 376 6 are be VBP cord-023726-2fduzqyb 376 7 shown show VBN cord-023726-2fduzqyb 376 8 in in IN cord-023726-2fduzqyb 376 9 Figs Figs NNPS cord-023726-2fduzqyb 376 10 . . . cord-023726-2fduzqyb 377 1 2.20B 2.20b CD cord-023726-2fduzqyb 377 2 and and CC cord-023726-2fduzqyb 377 3 2.20C 2.20c CD cord-023726-2fduzqyb 378 1 that that WDT cord-023726-2fduzqyb 378 2 illustrate illustrate VBP cord-023726-2fduzqyb 378 3 the the DT cord-023726-2fduzqyb 378 4 irregularity irregularity NN cord-023726-2fduzqyb 378 5 of of IN cord-023726-2fduzqyb 378 6 the the DT cord-023726-2fduzqyb 378 7 particle particle NN cord-023726-2fduzqyb 378 8 and and CC cord-023726-2fduzqyb 378 9 the the DT cord-023726-2fduzqyb 378 10 differing differ VBG cord-023726-2fduzqyb 378 11 thickness thickness NN cord-023726-2fduzqyb 378 12 of of IN cord-023726-2fduzqyb 378 13 the the DT cord-023726-2fduzqyb 378 14 tegument tegument NN cord-023726-2fduzqyb 378 15 in in IN cord-023726-2fduzqyb 378 16 different different JJ cord-023726-2fduzqyb 378 17 particles particle NNS cord-023726-2fduzqyb 378 18 . . . cord-023726-2fduzqyb 379 1 The the DT cord-023726-2fduzqyb 379 2 retroviruses retrovirus NNS cord-023726-2fduzqyb 379 3 have have VBP cord-023726-2fduzqyb 379 4 a a DT cord-023726-2fduzqyb 379 5 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 379 6 that that WDT cord-023726-2fduzqyb 379 7 forms form NNS cord-023726-2fduzqyb 379 8 initially initially RB cord-023726-2fduzqyb 379 9 using use VBG cord-023726-2fduzqyb 379 10 spherical spherical JJ cord-023726-2fduzqyb 379 11 symmetry symmetry NN cord-023726-2fduzqyb 379 12 principles principle NNS cord-023726-2fduzqyb 379 13 . . . cord-023726-2fduzqyb 380 1 Cleavage cleavage NN cord-023726-2fduzqyb 380 2 of of IN cord-023726-2fduzqyb 380 3 Gag gag NN cord-023726-2fduzqyb 380 4 during during IN cord-023726-2fduzqyb 380 5 virus virus NN cord-023726-2fduzqyb 380 6 maturation maturation NN cord-023726-2fduzqyb 380 7 results result VBZ cord-023726-2fduzqyb 380 8 in in IN cord-023726-2fduzqyb 380 9 a a DT cord-023726-2fduzqyb 380 10 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 380 11 that that WDT cord-023726-2fduzqyb 380 12 is be VBZ cord-023726-2fduzqyb 380 13 not not RB cord-023726-2fduzqyb 380 14 icosahedral icosahedral JJ cord-023726-2fduzqyb 380 15 and and CC cord-023726-2fduzqyb 380 16 that that DT cord-023726-2fduzqyb 380 17 is be VBZ cord-023726-2fduzqyb 380 18 often often RB cord-023726-2fduzqyb 380 19 eccentrically eccentrically RB cord-023726-2fduzqyb 380 20 located locate VBN cord-023726-2fduzqyb 380 21 in in IN cord-023726-2fduzqyb 380 22 the the DT cord-023726-2fduzqyb 380 23 virion virion NN cord-023726-2fduzqyb 380 24 . . . cord-023726-2fduzqyb 381 1 Fig Fig NNP cord-023726-2fduzqyb 381 2 . . . cord-023726-2fduzqyb 382 1 2 2 LS cord-023726-2fduzqyb 382 2 .21A .21A NFP cord-023726-2fduzqyb 382 3 presents present VBZ cord-023726-2fduzqyb 382 4 a a DT cord-023726-2fduzqyb 382 5 schematic schematic NN cord-023726-2fduzqyb 382 6 of of IN cord-023726-2fduzqyb 382 7 a a DT cord-023726-2fduzqyb 382 8 retrovirus retrovirus NN cord-023726-2fduzqyb 382 9 particle particle NN cord-023726-2fduzqyb 382 10 that that WDT cord-023726-2fduzqyb 382 11 illustrates illustrate VBZ cord-023726-2fduzqyb 382 12 the the DT cord-023726-2fduzqyb 382 13 current current JJ cord-023726-2fduzqyb 382 14 model model NN cord-023726-2fduzqyb 382 15 for for IN cord-023726-2fduzqyb 382 16 the the DT cord-023726-2fduzqyb 382 17 location location NN cord-023726-2fduzqyb 382 18 of of IN cord-023726-2fduzqyb 382 19 the the DT cord-023726-2fduzqyb 382 20 various various JJ cord-023726-2fduzqyb 382 21 proteins protein NNS cord-023726-2fduzqyb 382 22 after after IN cord-023726-2fduzqyb 382 23 cleavage cleavage NN cord-023726-2fduzqyb 382 24 of of IN cord-023726-2fduzqyb 382 25 Gag Gag NNP cord-023726-2fduzqyb 382 26 and and CC cord-023726-2fduzqyb 382 27 Gag Gag NNP cord-023726-2fduzqyb 382 28 - - HYPH cord-023726-2fduzqyb 382 29 Pol Pol NNP cord-023726-2fduzqyb 382 30 . . . cord-023726-2fduzqyb 383 1 Figs fig NNS cord-023726-2fduzqyb 383 2 . . . cord-023726-2fduzqyb 384 1 2.21B 2.21b CD cord-023726-2fduzqyb 384 2 , , , cord-023726-2fduzqyb 384 3 C C NNP cord-023726-2fduzqyb 384 4 , , , cord-023726-2fduzqyb 384 5 and and CC cord-023726-2fduzqyb 384 6 D d NN cord-023726-2fduzqyb 384 7 show show VBP cord-023726-2fduzqyb 384 8 electron electron NN cord-023726-2fduzqyb 384 9 micrographs micrograph NNS cord-023726-2fduzqyb 384 10 of of IN cord-023726-2fduzqyb 384 11 budding bud VBG cord-023726-2fduzqyb 384 12 virus virus NN cord-023726-2fduzqyb 384 13 particles particle NNS cord-023726-2fduzqyb 384 14 and and CC cord-023726-2fduzqyb 384 15 of of IN cord-023726-2fduzqyb 384 16 mature mature JJ cord-023726-2fduzqyb 384 17 extracellular extracellular JJ cord-023726-2fduzqyb 384 18 virions virion NNS cord-023726-2fduzqyb 384 19 for for IN cord-023726-2fduzqyb 384 20 three three CD cord-023726-2fduzqyb 384 21 genera genus NNS cord-023726-2fduzqyb 384 22 of of IN cord-023726-2fduzqyb 384 23 retroviruses retrovirus NNS cord-023726-2fduzqyb 384 24 . . . cord-023726-2fduzqyb 385 1 Betaretrovirus Betaretrovirus NNP cord-023726-2fduzqyb 385 2 particles particle NNS cord-023726-2fduzqyb 385 3 usually usually RB cord-023726-2fduzqyb 385 4 mature mature VBP cord-023726-2fduzqyb 385 5 by by IN cord-023726-2fduzqyb 385 6 the the DT cord-023726-2fduzqyb 385 7 formation formation NN cord-023726-2fduzqyb 385 8 of of IN cord-023726-2fduzqyb 385 9 a a DT cord-023726-2fduzqyb 385 10 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 385 11 within within IN cord-023726-2fduzqyb 385 12 the the DT cord-023726-2fduzqyb 385 13 cytoplasm cytoplasm NN cord-023726-2fduzqyb 385 14 that that WDT cord-023726-2fduzqyb 385 15 then then RB cord-023726-2fduzqyb 385 16 buds bud VBZ cord-023726-2fduzqyb 385 17 through through IN cord-023726-2fduzqyb 385 18 the the DT cord-023726-2fduzqyb 385 19 plasma plasma NN cord-023726-2fduzqyb 385 20 membrane membrane NN cord-023726-2fduzqyb 385 21 . . . cord-023726-2fduzqyb 386 1 This this DT cord-023726-2fduzqyb 386 2 process process NN cord-023726-2fduzqyb 386 3 is be VBZ cord-023726-2fduzqyb 386 4 shown show VBN cord-023726-2fduzqyb 386 5 in in IN cord-023726-2fduzqyb 386 6 Fig Fig NNP cord-023726-2fduzqyb 386 7 . . . cord-023726-2fduzqyb 387 1 2 2 LS cord-023726-2fduzqyb 387 2 .21B .21B . cord-023726-2fduzqyb 388 1 for for IN cord-023726-2fduzqyb 388 2 mouse mouse NN cord-023726-2fduzqyb 388 3 mammary mammary JJ cord-023726-2fduzqyb 388 4 tumor tumor NN cord-023726-2fduzqyb 388 5 virus virus NN cord-023726-2fduzqyb 388 6 . . . cord-023726-2fduzqyb 389 1 In in IN cord-023726-2fduzqyb 389 2 the the DT cord-023726-2fduzqyb 389 3 top top JJ cord-023726-2fduzqyb 389 4 micrograph micrograph NN cord-023726-2fduzqyb 389 5 in in IN cord-023726-2fduzqyb 389 6 Fig Fig NNP cord-023726-2fduzqyb 389 7 . . . cord-023726-2fduzqyb 389 8 _SP cord-023726-2fduzqyb 390 1 2 2 LS cord-023726-2fduzqyb 390 2 .21B .21B . cord-023726-2fduzqyb 391 1 , , , cord-023726-2fduzqyb 391 2 preassembled preassembled JJ cord-023726-2fduzqyb 391 3 capsids capsid NNS cord-023726-2fduzqyb 391 4 are be VBP cord-023726-2fduzqyb 391 5 seen see VBN cord-023726-2fduzqyb 391 6 in in IN cord-023726-2fduzqyb 391 7 the the DT cord-023726-2fduzqyb 391 8 cytoplasm cytoplasm NN cord-023726-2fduzqyb 391 9 . . . cord-023726-2fduzqyb 392 1 In in IN cord-023726-2fduzqyb 392 2 the the DT cord-023726-2fduzqyb 392 3 middle middle JJ cord-023726-2fduzqyb 392 4 micrograph micrograph NN cord-023726-2fduzqyb 392 5 , , , cord-023726-2fduzqyb 392 6 budding bud VBG cord-023726-2fduzqyb 392 7 of of IN cord-023726-2fduzqyb 392 8 the the DT cord-023726-2fduzqyb 392 9 capsid capsid NN cord-023726-2fduzqyb 392 10 through through IN cord-023726-2fduzqyb 392 11 the the DT cord-023726-2fduzqyb 392 12 plasma plasma NN cord-023726-2fduzqyb 392 13 membrane membrane NN cord-023726-2fduzqyb 392 14 is be VBZ cord-023726-2fduzqyb 392 15 illustrated illustrate VBN cord-023726-2fduzqyb 392 16 . . . cord-023726-2fduzqyb 393 1 In in IN cord-023726-2fduzqyb 393 2 the the DT cord-023726-2fduzqyb 393 3 bottom bottom JJ cord-023726-2fduzqyb 393 4 micrograph micrograph NN cord-023726-2fduzqyb 393 5 , , , cord-023726-2fduzqyb 393 6 a a DT cord-023726-2fduzqyb 393 7 mature mature JJ cord-023726-2fduzqyb 393 8 virion virion NN cord-023726-2fduzqyb 393 9 with with IN cord-023726-2fduzqyb 393 10 an an DT cord-023726-2fduzqyb 393 11 eccentrically eccentrically RB cord-023726-2fduzqyb 393 12 located locate VBN cord-023726-2fduzqyb 393 13 capsid capsid NN cord-023726-2fduzqyb 393 14 is be VBZ cord-023726-2fduzqyb 393 15 shown show VBN cord-023726-2fduzqyb 393 16 . . . cord-023726-2fduzqyb 394 1 In in IN cord-023726-2fduzqyb 394 2 gammaretroviruses gammaretroviruse NNS cord-023726-2fduzqyb 394 3 , , , cord-023726-2fduzqyb 394 4 the the DT cord-023726-2fduzqyb 394 5 capsid capsid NN cord-023726-2fduzqyb 394 6 forms form NNS cord-023726-2fduzqyb 394 7 during during IN cord-023726-2fduzqyb 394 8 budding bud VBG cord-023726-2fduzqyb 394 9 , , , cord-023726-2fduzqyb 394 10 and and CC cord-023726-2fduzqyb 394 11 the the DT cord-023726-2fduzqyb 394 12 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 394 13 is be VBZ cord-023726-2fduzqyb 394 14 round round JJ cord-023726-2fduzqyb 394 15 and and CC cord-023726-2fduzqyb 394 16 centrally centrally RB cord-023726-2fduzqyb 394 17 located locate VBN cord-023726-2fduzqyb 394 18 in in IN cord-023726-2fduzqyb 394 19 the the DT cord-023726-2fduzqyb 394 20 mature mature JJ cord-023726-2fduzqyb 394 21 virion virion NN cord-023726-2fduzqyb 394 22 . . . cord-023726-2fduzqyb 395 1 This this DT cord-023726-2fduzqyb 395 2 process process NN cord-023726-2fduzqyb 395 3 is be VBZ cord-023726-2fduzqyb 395 4 illustrated illustrate VBN cord-023726-2fduzqyb 395 5 in in IN cord-023726-2fduzqyb 395 6 Fig Fig NNP cord-023726-2fduzqyb 395 7 . . . cord-023726-2fduzqyb 396 1 2 2 LS cord-023726-2fduzqyb 396 2 .21C .21C NFP cord-023726-2fduzqyb 396 3 for for IN cord-023726-2fduzqyb 396 4 murine murine JJ cord-023726-2fduzqyb 396 5 leukemia leukemia NN cord-023726-2fduzqyb 396 6 virus virus NN cord-023726-2fduzqyb 396 7 . . . cord-023726-2fduzqyb 397 1 The the DT cord-023726-2fduzqyb 397 2 top top JJ cord-023726-2fduzqyb 397 3 micrograph micrograph NN cord-023726-2fduzqyb 397 4 shows show VBZ cord-023726-2fduzqyb 397 5 a a DT cord-023726-2fduzqyb 397 6 budding bud VBG cord-023726-2fduzqyb 397 7 particle particle NN cord-023726-2fduzqyb 397 8 with with IN cord-023726-2fduzqyb 397 9 a a DT cord-023726-2fduzqyb 397 10 partially partially RB cord-023726-2fduzqyb 397 11 assembled assemble VBN cord-023726-2fduzqyb 397 12 capsid capsid NN cord-023726-2fduzqyb 397 13 . . . cord-023726-2fduzqyb 398 1 The the DT cord-023726-2fduzqyb 398 2 bottom bottom JJ cord-023726-2fduzqyb 398 3 micrograph micrograph NN cord-023726-2fduzqyb 398 4 shows show VBZ cord-023726-2fduzqyb 398 5 a a DT cord-023726-2fduzqyb 398 6 mature mature JJ cord-023726-2fduzqyb 398 7 virion virion NN cord-023726-2fduzqyb 398 8 . . . cord-023726-2fduzqyb 399 1 In in IN cord-023726-2fduzqyb 399 2 the the DT cord-023726-2fduzqyb 399 3 lentiviruses lentiviruse NNS cord-023726-2fduzqyb 399 4 , , , cord-023726-2fduzqyb 399 5 of of IN cord-023726-2fduzqyb 399 6 which which WDT cord-023726-2fduzqyb 399 7 HIV HIV NNP cord-023726-2fduzqyb 399 8 is be VBZ cord-023726-2fduzqyb 399 9 a a DT cord-023726-2fduzqyb 399 10 member member NN cord-023726-2fduzqyb 399 11 , , , cord-023726-2fduzqyb 399 12 the the DT cord-023726-2fduzqyb 399 13 capsid capsid NN cord-023726-2fduzqyb 399 14 also also RB cord-023726-2fduzqyb 399 15 forms form VBZ cord-023726-2fduzqyb 399 16 as as IN cord-023726-2fduzqyb 399 17 a a DT cord-023726-2fduzqyb 399 18 distinct distinct JJ cord-023726-2fduzqyb 399 19 structure structure NN cord-023726-2fduzqyb 399 20 only only RB cord-023726-2fduzqyb 399 21 during during IN cord-023726-2fduzqyb 399 22 budding bud VBG cord-023726-2fduzqyb 399 23 . . . cord-023726-2fduzqyb 400 1 In in IN cord-023726-2fduzqyb 400 2 the the DT cord-023726-2fduzqyb 400 3 top top JJ cord-023726-2fduzqyb 400 4 panel panel NN cord-023726-2fduzqyb 400 5 of of IN cord-023726-2fduzqyb 400 6 Fig Fig NNP cord-023726-2fduzqyb 400 7 . . . cord-023726-2fduzqyb 401 1 2 2 LS cord-023726-2fduzqyb 401 2 .21D .21D NFP cord-023726-2fduzqyb 401 3 is be VBZ cord-023726-2fduzqyb 401 4 shown show VBN cord-023726-2fduzqyb 401 5 a a DT cord-023726-2fduzqyb 401 6 budding bud VBG cord-023726-2fduzqyb 401 7 particle particle NN cord-023726-2fduzqyb 401 8 of of IN cord-023726-2fduzqyb 401 9 bovine bovine JJ cord-023726-2fduzqyb 401 10 immunodeficiency immunodeficiency NN cord-023726-2fduzqyb 401 11 virus virus NN cord-023726-2fduzqyb 401 12 . . . cord-023726-2fduzqyb 402 1 After after IN cord-023726-2fduzqyb 402 2 cleavage cleavage NN cord-023726-2fduzqyb 402 3 of of IN cord-023726-2fduzqyb 402 4 Gag gag NN cord-023726-2fduzqyb 402 5 to to TO cord-023726-2fduzqyb 402 6 form form VB cord-023726-2fduzqyb 402 7 the the DT cord-023726-2fduzqyb 402 8 mature mature JJ cord-023726-2fduzqyb 402 9 virion virion NN cord-023726-2fduzqyb 402 10 , , , cord-023726-2fduzqyb 402 11 the the DT cord-023726-2fduzqyb 402 12 capsid capsid NN cord-023726-2fduzqyb 402 13 usually usually RB cord-023726-2fduzqyb 402 14 appears appear VBZ cord-023726-2fduzqyb 402 15 cone cone NN cord-023726-2fduzqyb 402 16 shaped shape VBN cord-023726-2fduzqyb 402 17 or or CC cord-023726-2fduzqyb 402 18 bar bar NN cord-023726-2fduzqyb 402 19 shaped shape VBN cord-023726-2fduzqyb 402 20 ( ( -LRB- cord-023726-2fduzqyb 402 21 bottom bottom JJ cord-023726-2fduzqyb 402 22 panel panel NN cord-023726-2fduzqyb 402 23 of of IN cord-023726-2fduzqyb 402 24 Fig Fig NNP cord-023726-2fduzqyb 402 25 . . . cord-023726-2fduzqyb 402 26 2.21D 2.21d CD cord-023726-2fduzqyb 402 27 ) ) -RRB- cord-023726-2fduzqyb 402 28 . . . cord-023726-2fduzqyb 403 1 Mason Mason NNP cord-023726-2fduzqyb 403 2 - - HYPH cord-023726-2fduzqyb 403 3 Pfizer Pfizer NNP cord-023726-2fduzqyb 403 4 monkey monkey NN cord-023726-2fduzqyb 403 5 virus virus NN cord-023726-2fduzqyb 403 6 is be VBZ cord-023726-2fduzqyb 403 7 a a DT cord-023726-2fduzqyb 403 8 betaretrovirus betaretrovirus NNP cord-023726-2fduzqyb 403 9 whose whose WP$ cord-023726-2fduzqyb 403 10 capsid capsid NN cord-023726-2fduzqyb 403 11 is be VBZ cord-023726-2fduzqyb 403 12 cone cone NN cord-023726-2fduzqyb 403 13 shaped shape VBN cord-023726-2fduzqyb 403 14 and and CC cord-023726-2fduzqyb 403 15 centrally centrally RB cord-023726-2fduzqyb 403 16 located locate VBN cord-023726-2fduzqyb 403 17 in in IN cord-023726-2fduzqyb 403 18 the the DT cord-023726-2fduzqyb 403 19 mature mature JJ cord-023726-2fduzqyb 403 20 virion virion NN cord-023726-2fduzqyb 403 21 . . . cord-023726-2fduzqyb 404 1 A a DT cord-023726-2fduzqyb 404 2 single single JJ cord-023726-2fduzqyb 404 3 amino amino NN cord-023726-2fduzqyb 404 4 acid acid NN cord-023726-2fduzqyb 404 5 change change NN cord-023726-2fduzqyb 404 6 in in IN cord-023726-2fduzqyb 404 7 the the DT cord-023726-2fduzqyb 404 8 matrix matrix NN cord-023726-2fduzqyb 404 9 protein protein NN cord-023726-2fduzqyb 404 10 MA MA NNP cord-023726-2fduzqyb 404 11 determines determine VBZ cord-023726-2fduzqyb 404 12 whether whether IN cord-023726-2fduzqyb 404 13 the the DT cord-023726-2fduzqyb 404 14 capsid capsid FW cord-023726-2fduzqyb 404 15 preassembles preassemble NNS cord-023726-2fduzqyb 404 16 and and CC cord-023726-2fduzqyb 404 17 then then RB cord-023726-2fduzqyb 404 18 buds bud NNS cord-023726-2fduzqyb 404 19 , , , cord-023726-2fduzqyb 404 20 or or CC cord-023726-2fduzqyb 404 21 whether whether IN cord-023726-2fduzqyb 404 22 the the DT cord-023726-2fduzqyb 404 23 capsids capsid NNS cord-023726-2fduzqyb 404 24 assemble assemble VBP cord-023726-2fduzqyb 404 25 during during IN cord-023726-2fduzqyb 404 26 budding bud VBG cord-023726-2fduzqyb 404 27 . . . cord-023726-2fduzqyb 405 1 Thus thus RB cord-023726-2fduzqyb 405 2 , , , cord-023726-2fduzqyb 405 3 the the DT cord-023726-2fduzqyb 405 4 point point NN cord-023726-2fduzqyb 405 5 at at IN cord-023726-2fduzqyb 405 6 which which WDT cord-023726-2fduzqyb 405 7 capsids capsid VBZ cord-023726-2fduzqyb 405 8 assemble assemble NN cord-023726-2fduzqyb 405 9 does do VBZ cord-023726-2fduzqyb 405 10 not not RB cord-023726-2fduzqyb 405 11 reflect reflect VB cord-023726-2fduzqyb 405 12 a a DT cord-023726-2fduzqyb 405 13 fundamental fundamental JJ cord-023726-2fduzqyb 405 14 difference difference NN cord-023726-2fduzqyb 405 15 in in IN cord-023726-2fduzqyb 405 16 retroviruses retrovirus NNS cord-023726-2fduzqyb 405 17 . . . cord-023726-2fduzqyb 406 1 Preassembly Preassembly NNP cord-023726-2fduzqyb 406 2 of of IN cord-023726-2fduzqyb 406 3 capsids capsid NNS cord-023726-2fduzqyb 406 4 or or CC cord-023726-2fduzqyb 406 5 assembly assembly NN cord-023726-2fduzqyb 406 6 during during IN cord-023726-2fduzqyb 406 7 budding bud VBG cord-023726-2fduzqyb 406 8 appears appear VBZ cord-023726-2fduzqyb 406 9 to to TO cord-023726-2fduzqyb 406 10 depend depend VB cord-023726-2fduzqyb 406 11 on on IN cord-023726-2fduzqyb 406 12 the the DT cord-023726-2fduzqyb 406 13 stability stability NN cord-023726-2fduzqyb 406 14 of of IN cord-023726-2fduzqyb 406 15 the the DT cord-023726-2fduzqyb 406 16 capsid capsid NN cord-023726-2fduzqyb 406 17 in in IN cord-023726-2fduzqyb 406 18 the the DT cord-023726-2fduzqyb 406 19 cell cell NN cord-023726-2fduzqyb 406 20 . . . cord-023726-2fduzqyb 407 1 Stable stable JJ cord-023726-2fduzqyb 407 2 capsids capsid NNS cord-023726-2fduzqyb 407 3 can can MD cord-023726-2fduzqyb 407 4 preassemble preassemble JJ cord-023726-2fduzqyb 407 5 . . . cord-023726-2fduzqyb 408 1 Unstable unstable JJ cord-023726-2fduzqyb 408 2 capsids capsid NNS cord-023726-2fduzqyb 408 3 require require VBP cord-023726-2fduzqyb 408 4 interactions interaction NNS cord-023726-2fduzqyb 408 5 with with IN cord-023726-2fduzqyb 408 6 other other JJ cord-023726-2fduzqyb 408 7 viral viral JJ cord-023726-2fduzqyb 408 8 components component NNS cord-023726-2fduzqyb 408 9 to to TO cord-023726-2fduzqyb 408 10 form form VB cord-023726-2fduzqyb 408 11 as as IN cord-023726-2fduzqyb 408 12 a a DT cord-023726-2fduzqyb 408 13 recognizable recognizable JJ cord-023726-2fduzqyb 408 14 structure structure NN cord-023726-2fduzqyb 408 15 . . . cord-023726-2fduzqyb 409 1 The the DT cord-023726-2fduzqyb 409 2 coronaviruses coronaviruse NNS cord-023726-2fduzqyb 409 3 and and CC cord-023726-2fduzqyb 409 4 the the DT cord-023726-2fduzqyb 409 5 minus minus JJ cord-023726-2fduzqyb 409 6 - - HYPH cord-023726-2fduzqyb 409 7 strand strand NN cord-023726-2fduzqyb 409 8 RNA RNA NNP cord-023726-2fduzqyb 409 9 viruses virus NNS cord-023726-2fduzqyb 409 10 have have VBP cord-023726-2fduzqyb 409 11 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 409 12 with with IN cord-023726-2fduzqyb 409 13 helical helical JJ cord-023726-2fduzqyb 409 14 symmetry symmetry NN cord-023726-2fduzqyb 409 15 . . . cord-023726-2fduzqyb 410 1 The the DT cord-023726-2fduzqyb 410 2 structures structure NNS cord-023726-2fduzqyb 410 3 of of IN cord-023726-2fduzqyb 410 4 the the DT cord-023726-2fduzqyb 410 5 mature mature JJ cord-023726-2fduzqyb 410 6 virions virion NNS cord-023726-2fduzqyb 410 7 are be VBP cord-023726-2fduzqyb 410 8 irregular irregular JJ cord-023726-2fduzqyb 410 9 , , , cord-023726-2fduzqyb 410 10 with with IN cord-023726-2fduzqyb 410 11 the the DT cord-023726-2fduzqyb 410 12 exception exception NN cord-023726-2fduzqyb 410 13 of of IN cord-023726-2fduzqyb 410 14 the the DT cord-023726-2fduzqyb 410 15 rhabdoviruses rhabdovirus NNS cord-023726-2fduzqyb 410 16 , , , cord-023726-2fduzqyb 410 17 and and CC cord-023726-2fduzqyb 410 18 the the DT cord-023726-2fduzqyb 410 19 glycoprotein glycoprotein NN cord-023726-2fduzqyb 410 20 composition composition NN cord-023726-2fduzqyb 410 21 is be VBZ cord-023726-2fduzqyb 410 22 not not RB cord-023726-2fduzqyb 410 23 invariant invariant JJ cord-023726-2fduzqyb 410 24 . . . cord-023726-2fduzqyb 411 1 Because because IN cord-023726-2fduzqyb 411 2 of of IN cord-023726-2fduzqyb 411 3 the the DT cord-023726-2fduzqyb 411 4 lack lack NN cord-023726-2fduzqyb 411 5 of of IN cord-023726-2fduzqyb 411 6 regularity regularity NN cord-023726-2fduzqyb 411 7 in in IN cord-023726-2fduzqyb 411 8 these these DT cord-023726-2fduzqyb 411 9 viruses virus NNS cord-023726-2fduzqyb 411 10 , , , cord-023726-2fduzqyb 411 11 as as RB cord-023726-2fduzqyb 411 12 well well RB cord-023726-2fduzqyb 411 13 as as IN cord-023726-2fduzqyb 411 14 the the DT cord-023726-2fduzqyb 411 15 lack lack NN cord-023726-2fduzqyb 411 16 of of IN cord-023726-2fduzqyb 411 17 symmetry symmetry NN cord-023726-2fduzqyb 411 18 , , , cord-023726-2fduzqyb 411 19 detailed detailed JJ cord-023726-2fduzqyb 411 20 structural structural JJ cord-023726-2fduzqyb 411 21 studies study NNS cord-023726-2fduzqyb 411 22 of of IN cord-023726-2fduzqyb 411 23 virions virion NNS cord-023726-2fduzqyb 411 24 have have VBP cord-023726-2fduzqyb 411 25 not not RB cord-023726-2fduzqyb 411 26 been be VBN cord-023726-2fduzqyb 411 27 possible possible JJ cord-023726-2fduzqyb 411 28 . . . cord-023726-2fduzqyb 412 1 The the DT cord-023726-2fduzqyb 412 2 lack lack NN cord-023726-2fduzqyb 412 3 of of IN cord-023726-2fduzqyb 412 4 regularity regularity NN cord-023726-2fduzqyb 412 5 arises arise VBZ cord-023726-2fduzqyb 412 6 in in IN cord-023726-2fduzqyb 412 7 part part NN cord-023726-2fduzqyb 412 8 because because IN cord-023726-2fduzqyb 412 9 in in IN cord-023726-2fduzqyb 412 10 these these DT cord-023726-2fduzqyb 412 11 viruses virus NNS cord-023726-2fduzqyb 412 12 there there EX cord-023726-2fduzqyb 412 13 is be VBZ cord-023726-2fduzqyb 412 14 no no DT cord-023726-2fduzqyb 412 15 direct direct JJ cord-023726-2fduzqyb 412 16 interaction interaction NN cord-023726-2fduzqyb 412 17 between between IN cord-023726-2fduzqyb 412 18 the the DT cord-023726-2fduzqyb 412 19 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 412 20 and and CC cord-023726-2fduzqyb 412 21 the the DT cord-023726-2fduzqyb 412 22 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 412 23 . . . cord-023726-2fduzqyb 413 1 The the DT cord-023726-2fduzqyb 413 2 lack lack NN cord-023726-2fduzqyb 413 3 of of IN cord-023726-2fduzqyb 413 4 such such JJ cord-023726-2fduzqyb 413 5 interactions interaction NNS cord-023726-2fduzqyb 413 6 permits permit VBZ cord-023726-2fduzqyb 413 7 these these DT cord-023726-2fduzqyb 413 8 viruses virus NNS cord-023726-2fduzqyb 413 9 to to TO cord-023726-2fduzqyb 413 10 form form VB cord-023726-2fduzqyb 413 11 pseudotypes pseudotype NNS cord-023726-2fduzqyb 413 12 , , , cord-023726-2fduzqyb 413 13 in in IN cord-023726-2fduzqyb 413 14 which which WDT cord-023726-2fduzqyb 413 15 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 413 16 from from IN cord-023726-2fduzqyb 413 17 other other JJ cord-023726-2fduzqyb 413 18 viruses virus NNS cord-023726-2fduzqyb 413 19 substitute substitute JJ cord-023726-2fduzqyb 413 20 for for IN cord-023726-2fduzqyb 413 21 those those DT cord-023726-2fduzqyb 413 22 of of IN cord-023726-2fduzqyb 413 23 the the DT cord-023726-2fduzqyb 413 24 virus virus NN cord-023726-2fduzqyb 413 25 in in IN cord-023726-2fduzqyb 413 26 question question NN cord-023726-2fduzqyb 413 27 . . . cord-023726-2fduzqyb 414 1 Pseudotypes pseudotype NNS cord-023726-2fduzqyb 414 2 are be VBP cord-023726-2fduzqyb 414 3 also also RB cord-023726-2fduzqyb 414 4 formed form VBN cord-023726-2fduzqyb 414 5 by by IN cord-023726-2fduzqyb 414 6 retroviruses retrovirus NNS cord-023726-2fduzqyb 414 7 . . . cord-023726-2fduzqyb 415 1 The the DT cord-023726-2fduzqyb 415 2 structures structure NNS cord-023726-2fduzqyb 415 3 of of IN cord-023726-2fduzqyb 415 4 paramyxoviruses paramyxovirus NNS cord-023726-2fduzqyb 415 5 and and CC cord-023726-2fduzqyb 415 6 orthomyxoviruses orthomyxoviruses NNP cord-023726-2fduzqyb 415 7 are be VBP cord-023726-2fduzqyb 415 8 illustrated illustrate VBN cord-023726-2fduzqyb 415 9 schematically schematically RB cord-023726-2fduzqyb 415 10 in in IN cord-023726-2fduzqyb 415 11 Fig Fig NNP cord-023726-2fduzqyb 415 12 . . . cord-023726-2fduzqyb 416 1 2.22 2.22 CD cord-023726-2fduzqyb 416 2 . . . cord-023726-2fduzqyb 417 1 The the DT cord-023726-2fduzqyb 417 2 helical helical JJ cord-023726-2fduzqyb 417 3 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 417 4 contain contain VBP cord-023726-2fduzqyb 417 5 a a DT cord-023726-2fduzqyb 417 6 major major JJ cord-023726-2fduzqyb 417 7 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 417 8 protein protein NN cord-023726-2fduzqyb 417 9 called call VBN cord-023726-2fduzqyb 417 10 N N NNP cord-023726-2fduzqyb 417 11 or or CC cord-023726-2fduzqyb 417 12 NP NP NNP cord-023726-2fduzqyb 417 13 , , , cord-023726-2fduzqyb 417 14 and and CC cord-023726-2fduzqyb 417 15 the the DT cord-023726-2fduzqyb 417 16 minor minor JJ cord-023726-2fduzqyb 417 17 proteins protein NNS cord-023726-2fduzqyb 417 18 P p NN cord-023726-2fduzqyb 417 19 ( ( -LRB- cord-023726-2fduzqyb 417 20 NS1 ns1 NN cord-023726-2fduzqyb 417 21 ) ) -RRB- cord-023726-2fduzqyb 417 22 and and CC cord-023726-2fduzqyb 417 23 L L NNP cord-023726-2fduzqyb 417 24 ( ( -LRB- cord-023726-2fduzqyb 417 25 PB1 PB1 NNP cord-023726-2fduzqyb 417 26 , , , cord-023726-2fduzqyb 417 27 PB2 PB2 NNP cord-023726-2fduzqyb 417 28 , , , cord-023726-2fduzqyb 417 29 PA PA NNP cord-023726-2fduzqyb 417 30 ) ) -RRB- cord-023726-2fduzqyb 417 31 , , , cord-023726-2fduzqyb 417 32 as as IN cord-023726-2fduzqyb 417 33 shown show VBN cord-023726-2fduzqyb 417 34 . . . cord-023726-2fduzqyb 418 1 There there EX cord-023726-2fduzqyb 418 2 is be VBZ cord-023726-2fduzqyb 418 3 a a DT cord-023726-2fduzqyb 418 4 matrix matrix NN cord-023726-2fduzqyb 418 5 protein protein NN cord-023726-2fduzqyb 418 6 M M NNP cord-023726-2fduzqyb 418 7 ( ( -LRB- cord-023726-2fduzqyb 418 8 M1 M1 NNP cord-023726-2fduzqyb 418 9 ) ) -RRB- cord-023726-2fduzqyb 418 10 lining line VBG cord-023726-2fduzqyb 418 11 the the DT cord-023726-2fduzqyb 418 12 inside inside NN cord-023726-2fduzqyb 418 13 of of IN cord-023726-2fduzqyb 418 14 the the DT cord-023726-2fduzqyb 418 15 lipid lipid NN cord-023726-2fduzqyb 418 16 bilayer bilayer NN cord-023726-2fduzqyb 418 17 and and CC cord-023726-2fduzqyb 418 18 also also RB cord-023726-2fduzqyb 418 19 two two CD cord-023726-2fduzqyb 418 20 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 418 21 anchored anchor VBN cord-023726-2fduzqyb 418 22 in in IN cord-023726-2fduzqyb 418 23 the the DT cord-023726-2fduzqyb 418 24 bilayer bilayer NN cord-023726-2fduzqyb 418 25 that that WDT cord-023726-2fduzqyb 418 26 form form VBP cord-023726-2fduzqyb 418 27 external external JJ cord-023726-2fduzqyb 418 28 spikes spike NNS cord-023726-2fduzqyb 418 29 . . . cord-023726-2fduzqyb 419 1 The the DT cord-023726-2fduzqyb 419 2 two two CD cord-023726-2fduzqyb 419 3 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 419 4 , , , cord-023726-2fduzqyb 419 5 called call VBN cord-023726-2fduzqyb 419 6 F F NNP cord-023726-2fduzqyb 419 7 and and CC cord-023726-2fduzqyb 419 8 HN HN NNP cord-023726-2fduzqyb 419 9 in in IN cord-023726-2fduzqyb 419 10 paramyxoviruses paramyxovirus NNS cord-023726-2fduzqyb 419 11 and and CC cord-023726-2fduzqyb 419 12 HA HA NNP cord-023726-2fduzqyb 419 13 and and CC cord-023726-2fduzqyb 419 14 NA NA NNP cord-023726-2fduzqyb 419 15 in in IN cord-023726-2fduzqyb 419 16 orthomyxoviruses orthomyxoviruses NNP cord-023726-2fduzqyb 419 17 , , , cord-023726-2fduzqyb 419 18 do do VBP cord-023726-2fduzqyb 419 19 not not RB cord-023726-2fduzqyb 419 20 form form VB cord-023726-2fduzqyb 419 21 heterodimers heterodimer NNS cord-023726-2fduzqyb 419 22 but but CC cord-023726-2fduzqyb 419 23 rather rather RB cord-023726-2fduzqyb 419 24 form form VB cord-023726-2fduzqyb 419 25 homooligomers homooligomer NNS cord-023726-2fduzqyb 419 26 so so IN cord-023726-2fduzqyb 419 27 that that IN cord-023726-2fduzqyb 419 28 there there EX cord-023726-2fduzqyb 419 29 are be VBP cord-023726-2fduzqyb 419 30 two two CD cord-023726-2fduzqyb 419 31 different different JJ cord-023726-2fduzqyb 419 32 kinds kind NNS cord-023726-2fduzqyb 419 33 of of IN cord-023726-2fduzqyb 419 34 spikes spike NNS cord-023726-2fduzqyb 419 35 on on IN cord-023726-2fduzqyb 419 36 the the DT cord-023726-2fduzqyb 419 37 surface surface NN cord-023726-2fduzqyb 419 38 of of IN cord-023726-2fduzqyb 419 39 the the DT cord-023726-2fduzqyb 419 40 virions virion NNS cord-023726-2fduzqyb 419 41 . . . cord-023726-2fduzqyb 420 1 HA HA NNP cord-023726-2fduzqyb 420 2 in in IN cord-023726-2fduzqyb 420 3 the the DT cord-023726-2fduzqyb 420 4 orthomyxoviruses orthomyxoviruses NNP cord-023726-2fduzqyb 420 5 forms form VBZ cord-023726-2fduzqyb 420 6 homotrimers homotrimer NNS cord-023726-2fduzqyb 420 7 whereas whereas IN cord-023726-2fduzqyb 420 8 NA NA NNP cord-023726-2fduzqyb 420 9 forms form VBZ cord-023726-2fduzqyb 420 10 homotetramers homotetramer NNS cord-023726-2fduzqyb 420 11 , , , cord-023726-2fduzqyb 420 12 and and CC cord-023726-2fduzqyb 420 13 the the DT cord-023726-2fduzqyb 420 14 two two CD cord-023726-2fduzqyb 420 15 types type NNS cord-023726-2fduzqyb 420 16 of of IN cord-023726-2fduzqyb 420 17 spikes spike NNS cord-023726-2fduzqyb 420 18 can can MD cord-023726-2fduzqyb 420 19 be be VB cord-023726-2fduzqyb 420 20 distinguished distinguish VBN cord-023726-2fduzqyb 420 21 in in IN cord-023726-2fduzqyb 420 22 the the DT cord-023726-2fduzqyb 420 23 electron electron NN cord-023726-2fduzqyb 420 24 microscope microscope NN cord-023726-2fduzqyb 420 25 if if IN cord-023726-2fduzqyb 420 26 the the DT cord-023726-2fduzqyb 420 27 resolution resolution NN cord-023726-2fduzqyb 420 28 is be VBZ cord-023726-2fduzqyb 420 29 high high JJ cord-023726-2fduzqyb 420 30 enough enough RB cord-023726-2fduzqyb 420 31 . . . cord-023726-2fduzqyb 421 1 As as IN cord-023726-2fduzqyb 421 2 occurs occur VBZ cord-023726-2fduzqyb 421 3 in in IN cord-023726-2fduzqyb 421 4 many many JJ cord-023726-2fduzqyb 421 5 enveloped envelop VBN cord-023726-2fduzqyb 421 6 RNA RNA NNP cord-023726-2fduzqyb 421 7 viruses virus NNS cord-023726-2fduzqyb 421 8 , , , cord-023726-2fduzqyb 421 9 F F NNP cord-023726-2fduzqyb 421 10 and and CC cord-023726-2fduzqyb 421 11 HA HA NNP cord-023726-2fduzqyb 421 12 are be VBP cord-023726-2fduzqyb 421 13 produced produce VBN cord-023726-2fduzqyb 421 14 as as IN cord-023726-2fduzqyb 421 15 precursors precursor NNS cord-023726-2fduzqyb 421 16 that that WDT cord-023726-2fduzqyb 421 17 are be VBP cord-023726-2fduzqyb 421 18 cleaved cleave VBN cord-023726-2fduzqyb 421 19 by by IN cord-023726-2fduzqyb 421 20 furin furin NN cord-023726-2fduzqyb 421 21 during during IN cord-023726-2fduzqyb 421 22 transport transport NN cord-023726-2fduzqyb 421 23 of of IN cord-023726-2fduzqyb 421 24 the the DT cord-023726-2fduzqyb 421 25 proteins protein NNS cord-023726-2fduzqyb 421 26 . . . cord-023726-2fduzqyb 422 1 Cleavage cleavage NN cord-023726-2fduzqyb 422 2 is be VBZ cord-023726-2fduzqyb 422 3 required require VBN cord-023726-2fduzqyb 422 4 to to TO cord-023726-2fduzqyb 422 5 activate activate VB cord-023726-2fduzqyb 422 6 the the DT cord-023726-2fduzqyb 422 7 fusion fusion NN cord-023726-2fduzqyb 422 8 peptide peptide NN cord-023726-2fduzqyb 422 9 of of IN cord-023726-2fduzqyb 422 10 the the DT cord-023726-2fduzqyb 422 11 virus virus NN cord-023726-2fduzqyb 422 12 , , , cord-023726-2fduzqyb 422 13 which which WDT cord-023726-2fduzqyb 422 14 is be VBZ cord-023726-2fduzqyb 422 15 found find VBN cord-023726-2fduzqyb 422 16 at at IN cord-023726-2fduzqyb 422 17 the the DT cord-023726-2fduzqyb 422 18 N n CD cord-023726-2fduzqyb 422 19 terminus terminus NN cord-023726-2fduzqyb 422 20 of of IN cord-023726-2fduzqyb 422 21 the the DT cord-023726-2fduzqyb 422 22 C C NNP cord-023726-2fduzqyb 422 23 - - HYPH cord-023726-2fduzqyb 422 24 terminal terminal NN cord-023726-2fduzqyb 422 25 product product NN cord-023726-2fduzqyb 422 26 ( ( -LRB- cord-023726-2fduzqyb 422 27 see see VB cord-023726-2fduzqyb 422 28 Fig Fig NNP cord-023726-2fduzqyb 422 29 . . . cord-023726-2fduzqyb 422 30 1.6 1.6 CD cord-023726-2fduzqyb 422 31 ) ) -RRB- cord-023726-2fduzqyb 422 32 . . . cord-023726-2fduzqyb 423 1 Electron electron NN cord-023726-2fduzqyb 423 2 micrographs micrograph NNS cord-023726-2fduzqyb 423 3 of of IN cord-023726-2fduzqyb 423 4 virions virion NNS cord-023726-2fduzqyb 423 5 are be VBP cord-023726-2fduzqyb 423 6 shown show VBN cord-023726-2fduzqyb 423 7 in in IN cord-023726-2fduzqyb 423 8 Figs Figs NNPS cord-023726-2fduzqyb 423 9 . . . cord-023726-2fduzqyb 424 1 2.22C 2.22C NNP cord-023726-2fduzqyb 424 2 and and CC cord-023726-2fduzqyb 424 3 D. D. NNP cord-023726-2fduzqyb 425 1 The the DT cord-023726-2fduzqyb 425 2 particles particle NNS cord-023726-2fduzqyb 425 3 in in IN cord-023726-2fduzqyb 425 4 the the DT cord-023726-2fduzqyb 425 5 preparations preparation NNS cord-023726-2fduzqyb 425 6 shown show VBN cord-023726-2fduzqyb 425 7 are be VBP cord-023726-2fduzqyb 425 8 round round JJ cord-023726-2fduzqyb 425 9 and and CC cord-023726-2fduzqyb 425 10 reasonably reasonably RB cord-023726-2fduzqyb 425 11 uniform uniform JJ cord-023726-2fduzqyb 425 12 , , , cord-023726-2fduzqyb 425 13 but but CC cord-023726-2fduzqyb 425 14 in in IN cord-023726-2fduzqyb 425 15 other other JJ cord-023726-2fduzqyb 425 16 preparations preparation NNS cord-023726-2fduzqyb 425 17 the the DT cord-023726-2fduzqyb 425 18 virions virion NNS cord-023726-2fduzqyb 425 19 are be VBP cord-023726-2fduzqyb 425 20 pleomorphic pleomorphic JJ cord-023726-2fduzqyb 425 21 baglike baglike JJ cord-023726-2fduzqyb 425 22 structures structure NNS cord-023726-2fduzqyb 425 23 that that WDT cord-023726-2fduzqyb 425 24 are be VBP cord-023726-2fduzqyb 425 25 not not RB cord-023726-2fduzqyb 425 26 uniform uniform JJ cord-023726-2fduzqyb 425 27 in in IN cord-023726-2fduzqyb 425 28 appearance appearance NN cord-023726-2fduzqyb 425 29 . . . cord-023726-2fduzqyb 426 1 In in IN cord-023726-2fduzqyb 426 2 fact fact NN cord-023726-2fduzqyb 426 3 , , , cord-023726-2fduzqyb 426 4 clinical clinical JJ cord-023726-2fduzqyb 426 5 specimens specimen NNS cord-023726-2fduzqyb 426 6 of of IN cord-023726-2fduzqyb 426 7 some some DT cord-023726-2fduzqyb 426 8 orthomyxoviruses orthomyxovirus NNS cord-023726-2fduzqyb 426 9 and and CC cord-023726-2fduzqyb 426 10 paramyxoviruses paramyxovirus NNS cord-023726-2fduzqyb 426 11 are be VBP cord-023726-2fduzqyb 426 12 often often RB cord-023726-2fduzqyb 426 13 filamentous filamentous JJ cord-023726-2fduzqyb 426 14 rather rather RB cord-023726-2fduzqyb 426 15 than than IN cord-023726-2fduzqyb 426 16 round round RB cord-023726-2fduzqyb 426 17 , , , cord-023726-2fduzqyb 426 18 illustrating illustrate VBG cord-023726-2fduzqyb 426 19 the the DT cord-023726-2fduzqyb 426 20 flexible flexible JJ cord-023726-2fduzqyb 426 21 nature nature NN cord-023726-2fduzqyb 426 22 of of IN cord-023726-2fduzqyb 426 23 the the DT cord-023726-2fduzqyb 426 24 structure structure NN cord-023726-2fduzqyb 426 25 of of IN cord-023726-2fduzqyb 426 26 the the DT cord-023726-2fduzqyb 426 27 virion virion NN cord-023726-2fduzqyb 426 28 . . . cord-023726-2fduzqyb 427 1 The the DT cord-023726-2fduzqyb 427 2 micrograph micrograph NN cord-023726-2fduzqyb 427 3 of of IN cord-023726-2fduzqyb 427 4 the the DT cord-023726-2fduzqyb 427 5 paramyxovirus paramyxovirus JJ cord-023726-2fduzqyb 427 6 measles measle NNS cord-023726-2fduzqyb 427 7 virus virus NN cord-023726-2fduzqyb 427 8 shown show VBN cord-023726-2fduzqyb 427 9 in in IN cord-023726-2fduzqyb 427 10 Fig Fig NNP cord-023726-2fduzqyb 427 11 . . . cord-023726-2fduzqyb 428 1 2 2 LS cord-023726-2fduzqyb 428 2 .22C .22C NFP cord-023726-2fduzqyb 428 3 is be VBZ cord-023726-2fduzqyb 428 4 a a DT cord-023726-2fduzqyb 428 5 thin thin JJ cord-023726-2fduzqyb 428 6 section section NN cord-023726-2fduzqyb 428 7 and and CC cord-023726-2fduzqyb 428 8 illustrates illustrate VBZ cord-023726-2fduzqyb 428 9 the the DT cord-023726-2fduzqyb 428 10 lack lack NN cord-023726-2fduzqyb 428 11 of of IN cord-023726-2fduzqyb 428 12 higher high JJR cord-023726-2fduzqyb 428 13 order order NN cord-023726-2fduzqyb 428 14 structure structure NN cord-023726-2fduzqyb 428 15 in in IN cord-023726-2fduzqyb 428 16 the the DT cord-023726-2fduzqyb 428 17 internal internal JJ cord-023726-2fduzqyb 428 18 helical helical JJ cord-023726-2fduzqyb 428 19 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 428 20 . . . cord-023726-2fduzqyb 429 1 The the DT cord-023726-2fduzqyb 429 2 micrograph micrograph NN cord-023726-2fduzqyb 429 3 of of IN cord-023726-2fduzqyb 429 4 the the DT cord-023726-2fduzqyb 429 5 orthomyxovirus orthomyxovirus NN cord-023726-2fduzqyb 429 6 influenza influenza NN cord-023726-2fduzqyb 429 7 A a DT cord-023726-2fduzqyb 429 8 virus virus NN cord-023726-2fduzqyb 429 9 shown show VBN cord-023726-2fduzqyb 429 10 in in IN cord-023726-2fduzqyb 429 11 Fig Fig NNP cord-023726-2fduzqyb 429 12 . . . cord-023726-2fduzqyb 430 1 2 2 LS cord-023726-2fduzqyb 430 2 .22D .22D . cord-023726-2fduzqyb 430 3 is be VBZ cord-023726-2fduzqyb 430 4 of of IN cord-023726-2fduzqyb 430 5 a a DT cord-023726-2fduzqyb 430 6 negative negative JJ cord-023726-2fduzqyb 430 7 - - HYPH cord-023726-2fduzqyb 430 8 stained stained JJ cord-023726-2fduzqyb 430 9 preparation preparation NN cord-023726-2fduzqyb 430 10 and and CC cord-023726-2fduzqyb 430 11 illustrates illustrate VBZ cord-023726-2fduzqyb 430 12 the the DT cord-023726-2fduzqyb 430 13 spikes spike NNS cord-023726-2fduzqyb 430 14 that that WDT cord-023726-2fduzqyb 430 15 decorate decorate VBP cord-023726-2fduzqyb 430 16 the the DT cord-023726-2fduzqyb 430 17 virus virus NN cord-023726-2fduzqyb 430 18 particle particle NN cord-023726-2fduzqyb 430 19 . . . cord-023726-2fduzqyb 431 1 The the DT cord-023726-2fduzqyb 431 2 structures structure NNS cord-023726-2fduzqyb 431 3 of of IN cord-023726-2fduzqyb 431 4 rhabdoviruses rhabdovirus NNS cord-023726-2fduzqyb 431 5 and and CC cord-023726-2fduzqyb 431 6 filoviruses filovirus NNS cord-023726-2fduzqyb 431 7 are be VBP cord-023726-2fduzqyb 431 8 illustrated illustrate VBN cord-023726-2fduzqyb 431 9 in in IN cord-023726-2fduzqyb 431 10 Fig Fig NNP cord-023726-2fduzqyb 431 11 . . . cord-023726-2fduzqyb 432 1 2 2 LS cord-023726-2fduzqyb 432 2 .23 .23 NFP cord-023726-2fduzqyb 432 3 . . . cord-023726-2fduzqyb 433 1 The the DT cord-023726-2fduzqyb 433 2 rhabdoviruses rhabdovirus NNS cord-023726-2fduzqyb 433 3 assemble assemble VBP cord-023726-2fduzqyb 433 4 into into IN cord-023726-2fduzqyb 433 5 bullet bullet NN cord-023726-2fduzqyb 433 6 - - HYPH cord-023726-2fduzqyb 433 7 shaped shape VBN cord-023726-2fduzqyb 433 8 or or CC cord-023726-2fduzqyb 433 9 bacilliform bacilliform NN cord-023726-2fduzqyb 433 10 particles particle NNS cord-023726-2fduzqyb 433 11 in in IN cord-023726-2fduzqyb 433 12 which which WDT cord-023726-2fduzqyb 433 13 the the DT cord-023726-2fduzqyb 433 14 helical helical JJ cord-023726-2fduzqyb 433 15 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 433 16 is be VBZ cord-023726-2fduzqyb 433 17 wound wind VBN cord-023726-2fduzqyb 433 18 in in IN cord-023726-2fduzqyb 433 19 a a DT cord-023726-2fduzqyb 433 20 regular regular JJ cord-023726-2fduzqyb 433 21 elongated elongated JJ cord-023726-2fduzqyb 433 22 spiral spiral JJ cord-023726-2fduzqyb 433 23 conformation conformation NN cord-023726-2fduzqyb 433 24 ( ( -LRB- cord-023726-2fduzqyb 433 25 Figs fig NNS cord-023726-2fduzqyb 433 26 . . . cord-023726-2fduzqyb 434 1 2.23B 2.23B NNP cord-023726-2fduzqyb 434 2 and and CC cord-023726-2fduzqyb 434 3 C C NNP cord-023726-2fduzqyb 434 4 ) ) -RRB- cord-023726-2fduzqyb 434 5 . . . cord-023726-2fduzqyb 435 1 The the DT cord-023726-2fduzqyb 435 2 virus virus NN cord-023726-2fduzqyb 435 3 encodes encode VBZ cord-023726-2fduzqyb 435 4 only only RB cord-023726-2fduzqyb 435 5 five five CD cord-023726-2fduzqyb 435 6 proteins protein NNS cord-023726-2fduzqyb 435 7 ( ( -LRB- cord-023726-2fduzqyb 435 8 Fig Fig NNP cord-023726-2fduzqyb 435 9 . . . cord-023726-2fduzqyb 435 10 2.23A 2.23a LS cord-023726-2fduzqyb 435 11 ) ) -RRB- cord-023726-2fduzqyb 435 12 , , , cord-023726-2fduzqyb 435 13 all all DT cord-023726-2fduzqyb 435 14 of of IN cord-023726-2fduzqyb 435 15 which which WDT cord-023726-2fduzqyb 435 16 occur occur VBP cord-023726-2fduzqyb 435 17 in in IN cord-023726-2fduzqyb 435 18 the the DT cord-023726-2fduzqyb 435 19 virion virion NN cord-023726-2fduzqyb 435 20 ( ( -LRB- cord-023726-2fduzqyb 435 21 Fig fig NN cord-023726-2fduzqyb 435 22 . . . cord-023726-2fduzqyb 435 23 _SP cord-023726-2fduzqyb 436 1 2.23B 2.23b LS cord-023726-2fduzqyb 436 2 ) ) -RRB- cord-023726-2fduzqyb 436 3 . . . cord-023726-2fduzqyb 437 1 The the DT cord-023726-2fduzqyb 437 2 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 437 3 contains contain VBZ cord-023726-2fduzqyb 437 4 the the DT cord-023726-2fduzqyb 437 5 major major JJ cord-023726-2fduzqyb 437 6 nucleocapsid nucleocapsid NNP cord-023726-2fduzqyb 437 7 protein protein NNP cord-023726-2fduzqyb 437 8 N N NNP cord-023726-2fduzqyb 437 9 and and CC cord-023726-2fduzqyb 437 10 the the DT cord-023726-2fduzqyb 437 11 two two CD cord-023726-2fduzqyb 437 12 minor minor JJ cord-023726-2fduzqyb 437 13 proteins protein NNS cord-023726-2fduzqyb 437 14 L L NNP cord-023726-2fduzqyb 437 15 and and CC cord-023726-2fduzqyb 437 16 NS NS NNP cord-023726-2fduzqyb 437 17 . . . cord-023726-2fduzqyb 438 1 The the DT cord-023726-2fduzqyb 438 2 matrix matrix NN cord-023726-2fduzqyb 438 3 protein protein NN cord-023726-2fduzqyb 438 4 M m CD cord-023726-2fduzqyb 438 5 lines line NNS cord-023726-2fduzqyb 438 6 the the DT cord-023726-2fduzqyb 438 7 inner inner JJ cord-023726-2fduzqyb 438 8 surface surface NN cord-023726-2fduzqyb 438 9 of of IN cord-023726-2fduzqyb 438 10 the the DT cord-023726-2fduzqyb 438 11 envelope envelope NN cord-023726-2fduzqyb 438 12 , , , cord-023726-2fduzqyb 438 13 and and CC cord-023726-2fduzqyb 438 14 G g NN cord-023726-2fduzqyb 438 15 is be VBZ cord-023726-2fduzqyb 438 16 an an DT cord-023726-2fduzqyb 438 17 external external JJ cord-023726-2fduzqyb 438 18 glycoprotein glycoprotein NN cord-023726-2fduzqyb 438 19 that that WDT cord-023726-2fduzqyb 438 20 is be VBZ cord-023726-2fduzqyb 438 21 anchored anchor VBN cord-023726-2fduzqyb 438 22 in in IN cord-023726-2fduzqyb 438 23 the the DT cord-023726-2fduzqyb 438 24 lipid lipid NN cord-023726-2fduzqyb 438 25 bilayer bilayer NN cord-023726-2fduzqyb 438 26 of of IN cord-023726-2fduzqyb 438 27 the the DT cord-023726-2fduzqyb 438 28 envelope envelope NN cord-023726-2fduzqyb 438 29 . . . cord-023726-2fduzqyb 439 1 Budding bud VBG cord-023726-2fduzqyb 439 2 is be VBZ cord-023726-2fduzqyb 439 3 from from IN cord-023726-2fduzqyb 439 4 the the DT cord-023726-2fduzqyb 439 5 plasma plasma NN cord-023726-2fduzqyb 439 6 membrane membrane NN cord-023726-2fduzqyb 439 7 ( ( -LRB- cord-023726-2fduzqyb 439 8 Fig Fig NNP cord-023726-2fduzqyb 439 9 . . . cord-023726-2fduzqyb 439 10 _SP cord-023726-2fduzqyb 439 11 2.23D 2.23d CD cord-023726-2fduzqyb 439 12 ) ) -RRB- cord-023726-2fduzqyb 439 13 . . . cord-023726-2fduzqyb 440 1 The the DT cord-023726-2fduzqyb 440 2 filoviruses filovirus NNS cord-023726-2fduzqyb 440 3 are be VBP cord-023726-2fduzqyb 440 4 so so RB cord-023726-2fduzqyb 440 5 named name VBN cord-023726-2fduzqyb 440 6 because because IN cord-023726-2fduzqyb 440 7 the the DT cord-023726-2fduzqyb 440 8 virion virion NN cord-023726-2fduzqyb 440 9 is be VBZ cord-023726-2fduzqyb 440 10 filamentous filamentous JJ cord-023726-2fduzqyb 440 11 . . . cord-023726-2fduzqyb 441 1 A a DT cord-023726-2fduzqyb 441 2 schematic schematic JJ cord-023726-2fduzqyb 441 3 diagram diagram NN cord-023726-2fduzqyb 441 4 of of IN cord-023726-2fduzqyb 441 5 a a DT cord-023726-2fduzqyb 441 6 filovirus filovirus NN cord-023726-2fduzqyb 441 7 is be VBZ cord-023726-2fduzqyb 441 8 shown show VBN cord-023726-2fduzqyb 441 9 in in IN cord-023726-2fduzqyb 441 10 Fig Fig NNP cord-023726-2fduzqyb 441 11 . . . cord-023726-2fduzqyb 441 12 _SP cord-023726-2fduzqyb 442 1 2 2 CD cord-023726-2fduzqyb 442 2 _SP cord-023726-2fduzqyb 443 1 The the DT cord-023726-2fduzqyb 443 2 Structure Structure NNP cord-023726-2fduzqyb 443 3 of of IN cord-023726-2fduzqyb 443 4 Viruses Viruses NNPS cord-023726-2fduzqyb 444 1 The the DT cord-023726-2fduzqyb 444 2 poxviruses poxvirus NNS cord-023726-2fduzqyb 444 3 , , , cord-023726-2fduzqyb 444 4 large large JJ cord-023726-2fduzqyb 444 5 DNA dna NN cord-023726-2fduzqyb 444 6 - - HYPH cord-023726-2fduzqyb 444 7 containing contain VBG cord-023726-2fduzqyb 444 8 viruses virus NNS cord-023726-2fduzqyb 444 9 , , , cord-023726-2fduzqyb 444 10 also also RB cord-023726-2fduzqyb 444 11 have have VBP cord-023726-2fduzqyb 444 12 lipid lipid NN cord-023726-2fduzqyb 444 13 envelopes envelope NNS cord-023726-2fduzqyb 444 14 . . . cord-023726-2fduzqyb 445 1 In in IN cord-023726-2fduzqyb 445 2 fact fact NN cord-023726-2fduzqyb 445 3 , , , cord-023726-2fduzqyb 445 4 they -PRON- PRP cord-023726-2fduzqyb 445 5 may may MD cord-023726-2fduzqyb 445 6 have have VB cord-023726-2fduzqyb 445 7 two two CD cord-023726-2fduzqyb 445 8 lipid lipid NN cord-023726-2fduzqyb 445 9 - - HYPH cord-023726-2fduzqyb 445 10 containing contain VBG cord-023726-2fduzqyb 445 11 envelopes envelope NNS cord-023726-2fduzqyb 445 12 . . . cord-023726-2fduzqyb 446 1 The the DT cord-023726-2fduzqyb 446 2 structures structure NNS cord-023726-2fduzqyb 446 3 of of IN cord-023726-2fduzqyb 446 4 poxviruses poxvirus NNS cord-023726-2fduzqyb 446 5 belonging belong VBG cord-023726-2fduzqyb 446 6 to to IN cord-023726-2fduzqyb 446 7 two two CD cord-023726-2fduzqyb 446 8 different different JJ cord-023726-2fduzqyb 446 9 genera genus NNS cord-023726-2fduzqyb 446 10 , , , cord-023726-2fduzqyb 446 11 Orthopox Orthopox NNP cord-023726-2fduzqyb 446 12 and and CC cord-023726-2fduzqyb 446 13 Parapox Parapox NNP cord-023726-2fduzqyb 446 14 , , , cord-023726-2fduzqyb 446 15 are be VBP cord-023726-2fduzqyb 446 16 illustrated illustrate VBN cord-023726-2fduzqyb 446 17 in in IN cord-023726-2fduzqyb 446 18 Fig Fig NNP cord-023726-2fduzqyb 446 19 . . . cord-023726-2fduzqyb 447 1 2 2 LS cord-023726-2fduzqyb 447 2 .24 .24 NFP cord-023726-2fduzqyb 447 3 . . . cord-023726-2fduzqyb 448 1 Electron electron NN cord-023726-2fduzqyb 448 2 micrographs micrograph NNS cord-023726-2fduzqyb 448 3 of of IN cord-023726-2fduzqyb 448 4 the the DT cord-023726-2fduzqyb 448 5 orthopox orthopox NNP cord-023726-2fduzqyb 448 6 virus virus NN cord-023726-2fduzqyb 448 7 vaccinia vaccinia NN cord-023726-2fduzqyb 448 8 virus virus NN cord-023726-2fduzqyb 448 9 and and CC cord-023726-2fduzqyb 448 10 of of IN cord-023726-2fduzqyb 448 11 a a DT cord-023726-2fduzqyb 448 12 parapox parapox JJ cord-023726-2fduzqyb 448 13 virus virus NN cord-023726-2fduzqyb 448 14 are be VBP cord-023726-2fduzqyb 448 15 also also RB cord-023726-2fduzqyb 448 16 shown show VBN cord-023726-2fduzqyb 448 17 . . . cord-023726-2fduzqyb 449 1 Vaccinia vaccinia NN cord-023726-2fduzqyb 449 2 virus virus NN cord-023726-2fduzqyb 449 3 has have VBZ cord-023726-2fduzqyb 449 4 been be VBN cord-023726-2fduzqyb 449 5 described describe VBN cord-023726-2fduzqyb 449 6 as as IN cord-023726-2fduzqyb 449 7 brick brick NN cord-023726-2fduzqyb 449 8 shaped shape VBN cord-023726-2fduzqyb 449 9 . . . cord-023726-2fduzqyb 450 1 The the DT cord-023726-2fduzqyb 450 2 interior interior NN cord-023726-2fduzqyb 450 3 of of IN cord-023726-2fduzqyb 450 4 the the DT cord-023726-2fduzqyb 450 5 virion virion NN cord-023726-2fduzqyb 450 6 consists consist VBZ cord-023726-2fduzqyb 450 7 of of IN cord-023726-2fduzqyb 450 8 a a DT cord-023726-2fduzqyb 450 9 nucleoprotein nucleoprotein NNP cord-023726-2fduzqyb 450 10 core core NN cord-023726-2fduzqyb 450 11 and and CC cord-023726-2fduzqyb 450 12 two two CD cord-023726-2fduzqyb 450 13 ( ( -LRB- cord-023726-2fduzqyb 450 14 in in IN cord-023726-2fduzqyb 450 15 vertebrate vertebrate JJ cord-023726-2fduzqyb 450 16 viruses virus NNS cord-023726-2fduzqyb 450 17 ) ) -RRB- cord-023726-2fduzqyb 450 18 proteinaceous proteinaceous JJ cord-023726-2fduzqyb 450 19 lateral lateral JJ cord-023726-2fduzqyb 450 20 bodies body NNS cord-023726-2fduzqyb 450 21 . . . cord-023726-2fduzqyb 451 1 Surrounding surround VBG cord-023726-2fduzqyb 451 2 these these DT cord-023726-2fduzqyb 451 3 is be VBZ cord-023726-2fduzqyb 451 4 a a DT cord-023726-2fduzqyb 451 5 lipid lipid NN cord-023726-2fduzqyb 451 6 - - HYPH cord-023726-2fduzqyb 451 7 containing contain VBG cord-023726-2fduzqyb 451 8 surface surface NN cord-023726-2fduzqyb 451 9 membrane membrane NN cord-023726-2fduzqyb 451 10 , , , cord-023726-2fduzqyb 451 11 outside outside RB cord-023726-2fduzqyb 451 12 of of IN cord-023726-2fduzqyb 451 13 which which WDT cord-023726-2fduzqyb 451 14 are be VBP cord-023726-2fduzqyb 451 15 several several JJ cord-023726-2fduzqyb 451 16 virus virus NN cord-023726-2fduzqyb 451 17 - - HYPH cord-023726-2fduzqyb 451 18 encoded encode VBN cord-023726-2fduzqyb 451 19 proteins protein NNS cord-023726-2fduzqyb 451 20 present present JJ cord-023726-2fduzqyb 451 21 in in IN cord-023726-2fduzqyb 451 22 structures structure NNS cord-023726-2fduzqyb 451 23 referred refer VBN cord-023726-2fduzqyb 451 24 to to IN cord-023726-2fduzqyb 451 25 as as IN cord-023726-2fduzqyb 451 26 tubules tubule NNS cord-023726-2fduzqyb 451 27 . . . cord-023726-2fduzqyb 452 1 This this DT cord-023726-2fduzqyb 452 2 particle particle NN cord-023726-2fduzqyb 452 3 is be VBZ cord-023726-2fduzqyb 452 4 called call VBN cord-023726-2fduzqyb 452 5 an an DT cord-023726-2fduzqyb 452 6 intracellular intracellular JJ cord-023726-2fduzqyb 452 7 infectious infectious JJ cord-023726-2fduzqyb 452 8 virion virion NN cord-023726-2fduzqyb 452 9 . . . cord-023726-2fduzqyb 453 1 As as IN cord-023726-2fduzqyb 453 2 its -PRON- PRP$ cord-023726-2fduzqyb 453 3 name name NN cord-023726-2fduzqyb 453 4 implies imply VBZ cord-023726-2fduzqyb 453 5 , , , cord-023726-2fduzqyb 453 6 it -PRON- PRP cord-023726-2fduzqyb 453 7 is be VBZ cord-023726-2fduzqyb 453 8 present present JJ cord-023726-2fduzqyb 453 9 inside inside IN cord-023726-2fduzqyb 453 10 an an DT cord-023726-2fduzqyb 453 11 infected infected JJ cord-023726-2fduzqyb 453 12 cell cell NN cord-023726-2fduzqyb 453 13 , , , cord-023726-2fduzqyb 453 14 and and CC cord-023726-2fduzqyb 453 15 if if IN cord-023726-2fduzqyb 453 16 freed free VBN cord-023726-2fduzqyb 453 17 from from IN cord-023726-2fduzqyb 453 18 the the DT cord-023726-2fduzqyb 453 19 cell cell NN cord-023726-2fduzqyb 453 20 it -PRON- PRP cord-023726-2fduzqyb 453 21 is be VBZ cord-023726-2fduzqyb 453 22 infectious infectious JJ cord-023726-2fduzqyb 453 23 . . . cord-023726-2fduzqyb 454 1 A a DT cord-023726-2fduzqyb 454 2 second second JJ cord-023726-2fduzqyb 454 3 form form NN cord-023726-2fduzqyb 454 4 of of IN cord-023726-2fduzqyb 454 5 the the DT cord-023726-2fduzqyb 454 6 virion virion NN cord-023726-2fduzqyb 454 7 is be VBZ cord-023726-2fduzqyb 454 8 found find VBN cord-023726-2fduzqyb 454 9 outside outside IN cord-023726-2fduzqyb 454 10 the the DT cord-023726-2fduzqyb 454 11 cell cell NN cord-023726-2fduzqyb 454 12 and and CC cord-023726-2fduzqyb 454 13 is be VBZ cord-023726-2fduzqyb 454 14 called call VBN cord-023726-2fduzqyb 454 15 an an DT cord-023726-2fduzqyb 454 16 extracellular extracellular JJ cord-023726-2fduzqyb 454 17 enveloped envelop VBN cord-023726-2fduzqyb 454 18 virion virion NN cord-023726-2fduzqyb 454 19 . . . cord-023726-2fduzqyb 455 1 This this DT cord-023726-2fduzqyb 455 2 second second JJ cord-023726-2fduzqyb 455 3 form form NN cord-023726-2fduzqyb 455 4 has have VBZ cord-023726-2fduzqyb 455 5 a a DT cord-023726-2fduzqyb 455 6 second second JJ cord-023726-2fduzqyb 455 7 , , , cord-023726-2fduzqyb 455 8 external external JJ cord-023726-2fduzqyb 455 9 lipid lipid NN cord-023726-2fduzqyb 455 10 - - HYPH cord-023726-2fduzqyb 455 11 containing contain VBG cord-023726-2fduzqyb 455 12 envelope envelope NN cord-023726-2fduzqyb 455 13 with with IN cord-023726-2fduzqyb 455 14 which which WDT cord-023726-2fduzqyb 455 15 is be VBZ cord-023726-2fduzqyb 455 16 associated associate VBN cord-023726-2fduzqyb 455 17 five five CD cord-023726-2fduzqyb 455 18 additional additional JJ cord-023726-2fduzqyb 455 19 vaccinia vaccinia NN cord-023726-2fduzqyb 455 20 proteins protein NNS cord-023726-2fduzqyb 455 21 . . . cord-023726-2fduzqyb 456 1 This this DT cord-023726-2fduzqyb 456 2 form form NN cord-023726-2fduzqyb 456 3 of of IN cord-023726-2fduzqyb 456 4 the the DT cord-023726-2fduzqyb 456 5 virion virion NN cord-023726-2fduzqyb 456 6 is be VBZ cord-023726-2fduzqyb 456 7 also also RB cord-023726-2fduzqyb 456 8 infectious infectious JJ cord-023726-2fduzqyb 456 9 . . . cord-023726-2fduzqyb 457 1 Parapox Parapox NNP cord-023726-2fduzqyb 457 2 virions virion NNS cord-023726-2fduzqyb 457 3 are be VBP cord-023726-2fduzqyb 457 4 similar similar JJ cord-023726-2fduzqyb 457 5 to to IN cord-023726-2fduzqyb 457 6 orthopox orthopox NNP cord-023726-2fduzqyb 457 7 virions virion NNS cord-023726-2fduzqyb 457 8 . . . cord-023726-2fduzqyb 458 1 However however RB cord-023726-2fduzqyb 458 2 , , , cord-023726-2fduzqyb 458 3 their -PRON- PRP$ cord-023726-2fduzqyb 458 4 morphology morphology NN cord-023726-2fduzqyb 458 5 is be VBZ cord-023726-2fduzqyb 458 6 detectably detectably RB cord-023726-2fduzqyb 458 7 different different JJ cord-023726-2fduzqyb 458 8 , , , cord-023726-2fduzqyb 458 9 as as IN cord-023726-2fduzqyb 458 10 illustrated illustrate VBN cord-023726-2fduzqyb 458 11 in in IN cord-023726-2fduzqyb 458 12 Fig Fig NNP cord-023726-2fduzqyb 458 13 . . . cord-023726-2fduzqyb 459 1 2 2 LS cord-023726-2fduzqyb 459 2 .24 .24 NFP cord-023726-2fduzqyb 459 3 . . . cord-023726-2fduzqyb 460 1 Virions Virions NNP cord-023726-2fduzqyb 460 2 self self NN cord-023726-2fduzqyb 460 3 - - HYPH cord-023726-2fduzqyb 460 4 assemble assemble VBP cord-023726-2fduzqyb 460 5 within within IN cord-023726-2fduzqyb 460 6 the the DT cord-023726-2fduzqyb 460 7 infected infected JJ cord-023726-2fduzqyb 460 8 cell cell NN cord-023726-2fduzqyb 460 9 . . . cord-023726-2fduzqyb 461 1 In in IN cord-023726-2fduzqyb 461 2 most most JJS cord-023726-2fduzqyb 461 3 cases case NNS cord-023726-2fduzqyb 461 4 , , , cord-023726-2fduzqyb 461 5 assembly assembly NN cord-023726-2fduzqyb 461 6 appears appear VBZ cord-023726-2fduzqyb 461 7 to to TO cord-023726-2fduzqyb 461 8 begin begin VB cord-023726-2fduzqyb 461 9 with with IN cord-023726-2fduzqyb 461 10 the the DT cord-023726-2fduzqyb 461 11 interaction interaction NN cord-023726-2fduzqyb 461 12 of of IN cord-023726-2fduzqyb 461 13 one one CD cord-023726-2fduzqyb 461 14 or or CC cord-023726-2fduzqyb 461 15 more more JJR cord-023726-2fduzqyb 461 16 of of IN cord-023726-2fduzqyb 461 17 the the DT cord-023726-2fduzqyb 461 18 structural structural JJ cord-023726-2fduzqyb 461 19 proteins protein NNS cord-023726-2fduzqyb 461 20 with with IN cord-023726-2fduzqyb 461 21 an an DT cord-023726-2fduzqyb 461 22 encapsidation encapsidation NN cord-023726-2fduzqyb 461 23 signal signal NN cord-023726-2fduzqyb 461 24 in in IN cord-023726-2fduzqyb 461 25 the the DT cord-023726-2fduzqyb 461 26 viral viral JJ cord-023726-2fduzqyb 461 27 genome genome NN cord-023726-2fduzqyb 461 28 , , , cord-023726-2fduzqyb 461 29 which which WDT cord-023726-2fduzqyb 461 30 ensures ensure VBZ cord-023726-2fduzqyb 461 31 that that IN cord-023726-2fduzqyb 461 32 viral viral JJ cord-023726-2fduzqyb 461 33 genomes genome NNS cord-023726-2fduzqyb 461 34 are be VBP cord-023726-2fduzqyb 461 35 preferentially preferentially RB cord-023726-2fduzqyb 461 36 packaged package VBN cord-023726-2fduzqyb 461 37 . . . cord-023726-2fduzqyb 462 1 After after IN cord-023726-2fduzqyb 462 2 initiation initiation NN cord-023726-2fduzqyb 462 3 , , , cord-023726-2fduzqyb 462 4 encapsidation encapsidation NN cord-023726-2fduzqyb 462 5 continues continue VBZ cord-023726-2fduzqyb 462 6 by by IN cord-023726-2fduzqyb 462 7 recruitment recruitment NN cord-023726-2fduzqyb 462 8 of of IN cord-023726-2fduzqyb 462 9 additional additional JJ cord-023726-2fduzqyb 462 10 structural structural JJ cord-023726-2fduzqyb 462 11 protein protein NN cord-023726-2fduzqyb 462 12 molecules molecule NNS cord-023726-2fduzqyb 462 13 until until IN cord-023726-2fduzqyb 462 14 the the DT cord-023726-2fduzqyb 462 15 complete complete JJ cord-023726-2fduzqyb 462 16 helical helical JJ cord-023726-2fduzqyb 462 17 or or CC cord-023726-2fduzqyb 462 18 icosahedral icosahedral JJ cord-023726-2fduzqyb 462 19 structure structure NN cord-023726-2fduzqyb 462 20 has have VBZ cord-023726-2fduzqyb 462 21 been be VBN cord-023726-2fduzqyb 462 22 assembled assemble VBN cord-023726-2fduzqyb 462 23 . . . cord-023726-2fduzqyb 463 1 Thus thus RB cord-023726-2fduzqyb 463 2 , , , cord-023726-2fduzqyb 463 3 packaging packaging NN cord-023726-2fduzqyb 463 4 of of IN cord-023726-2fduzqyb 463 5 the the DT cord-023726-2fduzqyb 463 6 viral viral JJ cord-023726-2fduzqyb 463 7 genome genome NN cord-023726-2fduzqyb 463 8 is be VBZ cord-023726-2fduzqyb 463 9 coincident coincident JJ cord-023726-2fduzqyb 463 10 with with IN cord-023726-2fduzqyb 463 11 assembly assembly NN cord-023726-2fduzqyb 463 12 of of IN cord-023726-2fduzqyb 463 13 the the DT cord-023726-2fduzqyb 463 14 virion virion NN cord-023726-2fduzqyb 463 15 , , , cord-023726-2fduzqyb 463 16 or or CC cord-023726-2fduzqyb 463 17 of of IN cord-023726-2fduzqyb 463 18 the the DT cord-023726-2fduzqyb 463 19 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 463 20 in in IN cord-023726-2fduzqyb 463 21 the the DT cord-023726-2fduzqyb 463 22 case case NN cord-023726-2fduzqyb 463 23 of of IN cord-023726-2fduzqyb 463 24 enveloped envelop VBN cord-023726-2fduzqyb 463 25 viruses virus NNS cord-023726-2fduzqyb 463 26 . . . cord-023726-2fduzqyb 464 1 The the DT cord-023726-2fduzqyb 464 2 requirement requirement NN cord-023726-2fduzqyb 464 3 for for IN cord-023726-2fduzqyb 464 4 a a DT cord-023726-2fduzqyb 464 5 packaging packaging NN cord-023726-2fduzqyb 464 6 signal signal NN cord-023726-2fduzqyb 464 7 may may MD cord-023726-2fduzqyb 464 8 not not RB cord-023726-2fduzqyb 464 9 be be VB cord-023726-2fduzqyb 464 10 absolute absolute JJ cord-023726-2fduzqyb 464 11 . . . cord-023726-2fduzqyb 465 1 In in IN cord-023726-2fduzqyb 465 2 many many JJ cord-023726-2fduzqyb 465 3 viruses virus NNS cord-023726-2fduzqyb 465 4 that that WDT cord-023726-2fduzqyb 465 5 contain contain VBP cord-023726-2fduzqyb 465 6 an an DT cord-023726-2fduzqyb 465 7 encapsidation encapsidation NN cord-023726-2fduzqyb 465 8 signal signal NN cord-023726-2fduzqyb 465 9 , , , cord-023726-2fduzqyb 465 10 RNAs rna NNS cord-023726-2fduzqyb 465 11 or or CC cord-023726-2fduzqyb 465 12 DNAs dna NNS cord-023726-2fduzqyb 465 13 lacking lack VBG cord-023726-2fduzqyb 465 14 such such PDT cord-023726-2fduzqyb 465 15 a a DT cord-023726-2fduzqyb 465 16 signal signal NN cord-023726-2fduzqyb 465 17 may may MD cord-023726-2fduzqyb 465 18 be be VB cord-023726-2fduzqyb 465 19 encapsidated encapsidate VBN cord-023726-2fduzqyb 465 20 , , , cord-023726-2fduzqyb 465 21 but but CC cord-023726-2fduzqyb 465 22 with with IN cord-023726-2fduzqyb 465 23 much much RB cord-023726-2fduzqyb 465 24 lower low JJR cord-023726-2fduzqyb 465 25 efficiency efficiency NN cord-023726-2fduzqyb 465 26 . . . cord-023726-2fduzqyb 466 1 For for IN cord-023726-2fduzqyb 466 2 some some DT cord-023726-2fduzqyb 466 3 viruses virus NNS cord-023726-2fduzqyb 466 4 , , , cord-023726-2fduzqyb 466 5 there there EX cord-023726-2fduzqyb 466 6 is be VBZ cord-023726-2fduzqyb 466 7 no no DT cord-023726-2fduzqyb 466 8 evidence evidence NN cord-023726-2fduzqyb 466 9 for for IN cord-023726-2fduzqyb 466 10 an an DT cord-023726-2fduzqyb 466 11 encapsidation encapsidation NN cord-023726-2fduzqyb 466 12 signal signal NN cord-023726-2fduzqyb 466 13 . . . cord-023726-2fduzqyb 467 1 Assembly assembly NN cord-023726-2fduzqyb 467 2 of of IN cord-023726-2fduzqyb 467 3 the the DT cord-023726-2fduzqyb 467 4 TMV TMV NNP cord-023726-2fduzqyb 467 5 rod rod NN cord-023726-2fduzqyb 467 6 ( ( -LRB- cord-023726-2fduzqyb 467 7 Fig Fig NNP cord-023726-2fduzqyb 467 8 . . NNP cord-023726-2fduzqyb 467 9 2 2 CD cord-023726-2fduzqyb 467 10 . . . cord-023726-2fduzqyb 467 11 2 2 LS cord-023726-2fduzqyb 467 12 ) ) -RRB- cord-023726-2fduzqyb 467 13 has have VBZ cord-023726-2fduzqyb 467 14 been be VBN cord-023726-2fduzqyb 467 15 well well RB cord-023726-2fduzqyb 467 16 studied study VBN cord-023726-2fduzqyb 467 17 . . . cord-023726-2fduzqyb 468 1 Several several JJ cord-023726-2fduzqyb 468 2 coat coat NN cord-023726-2fduzqyb 468 3 protein protein NN cord-023726-2fduzqyb 468 4 molecules molecule NNS cord-023726-2fduzqyb 468 5 , , , cord-023726-2fduzqyb 468 6 perhaps perhaps RB cord-023726-2fduzqyb 468 7 in in IN cord-023726-2fduzqyb 468 8 the the DT cord-023726-2fduzqyb 468 9 form form NN cord-023726-2fduzqyb 468 10 of of IN cord-023726-2fduzqyb 468 11 a a DT cord-023726-2fduzqyb 468 12 disk disk NN cord-023726-2fduzqyb 468 13 , , , cord-023726-2fduzqyb 468 14 bind bind VB cord-023726-2fduzqyb 468 15 to to IN cord-023726-2fduzqyb 468 16 a a DT cord-023726-2fduzqyb 468 17 specific specific JJ cord-023726-2fduzqyb 468 18 nucleation nucleation NN cord-023726-2fduzqyb 468 19 site site NN cord-023726-2fduzqyb 468 20 within within IN cord-023726-2fduzqyb 468 21 TMV TMV NNP cord-023726-2fduzqyb 468 22 RNA RNA NNP cord-023726-2fduzqyb 468 23 to to TO cord-023726-2fduzqyb 468 24 initiate initiate VB cord-023726-2fduzqyb 468 25 encapsidation encapsidation NN cord-023726-2fduzqyb 468 26 . . . cord-023726-2fduzqyb 469 1 Once once IN cord-023726-2fduzqyb 469 2 the the DT cord-023726-2fduzqyb 469 3 nucleation nucleation NN cord-023726-2fduzqyb 469 4 event event NN cord-023726-2fduzqyb 469 5 occurs occur VBZ cord-023726-2fduzqyb 469 6 , , , cord-023726-2fduzqyb 469 7 additional additional JJ cord-023726-2fduzqyb 469 8 protein protein NN cord-023726-2fduzqyb 469 9 subunits subunit NNS cord-023726-2fduzqyb 469 10 are be VBP cord-023726-2fduzqyb 469 11 recruited recruit VBN cord-023726-2fduzqyb 469 12 into into IN cord-023726-2fduzqyb 469 13 the the DT cord-023726-2fduzqyb 469 14 structure structure NN cord-023726-2fduzqyb 469 15 and and CC cord-023726-2fduzqyb 469 16 assembly assembly NN cord-023726-2fduzqyb 469 17 proceeds proceed NNS cord-023726-2fduzqyb 469 18 in in IN cord-023726-2fduzqyb 469 19 both both DT cord-023726-2fduzqyb 469 20 directions direction NNS cord-023726-2fduzqyb 469 21 until until IN cord-023726-2fduzqyb 469 22 the the DT cord-023726-2fduzqyb 469 23 RNA RNA NNP cord-023726-2fduzqyb 469 24 is be VBZ cord-023726-2fduzqyb 469 25 completely completely RB cord-023726-2fduzqyb 469 26 encapsidated encapsidate VBN cord-023726-2fduzqyb 469 27 . . . cord-023726-2fduzqyb 470 1 The the DT cord-023726-2fduzqyb 470 2 length length NN cord-023726-2fduzqyb 470 3 of of IN cord-023726-2fduzqyb 470 4 the the DT cord-023726-2fduzqyb 470 5 virion virion NN cord-023726-2fduzqyb 470 6 is be VBZ cord-023726-2fduzqyb 470 7 thus thus RB cord-023726-2fduzqyb 470 8 determined determine VBN cord-023726-2fduzqyb 470 9 by by IN cord-023726-2fduzqyb 470 10 the the DT cord-023726-2fduzqyb 470 11 size size NN cord-023726-2fduzqyb 470 12 of of IN cord-023726-2fduzqyb 470 13 the the DT cord-023726-2fduzqyb 470 14 RNA RNA NNP cord-023726-2fduzqyb 470 15 . . . cord-023726-2fduzqyb 471 1 The the DT cord-023726-2fduzqyb 471 2 assembly assembly NN cord-023726-2fduzqyb 471 3 of of IN cord-023726-2fduzqyb 471 4 the the DT cord-023726-2fduzqyb 471 5 icosahedral icosahedral JJ cord-023726-2fduzqyb 471 6 turnip turnip NN cord-023726-2fduzqyb 471 7 crinkle crinkle NN cord-023726-2fduzqyb 471 8 virion virion NN cord-023726-2fduzqyb 471 9 has have VBZ cord-023726-2fduzqyb 471 10 also also RB cord-023726-2fduzqyb 471 11 been be VBN cord-023726-2fduzqyb 471 12 well well RB cord-023726-2fduzqyb 471 13 studied study VBN cord-023726-2fduzqyb 471 14 . . . cord-023726-2fduzqyb 472 1 Assembly assembly NN cord-023726-2fduzqyb 472 2 of of IN cord-023726-2fduzqyb 472 3 this this DT cord-023726-2fduzqyb 472 4 T=3 T=3 NNP cord-023726-2fduzqyb 472 5 structure structure NN cord-023726-2fduzqyb 472 6 is be VBZ cord-023726-2fduzqyb 472 7 initiated initiate VBN cord-023726-2fduzqyb 472 8 by by IN cord-023726-2fduzqyb 472 9 formation formation NN cord-023726-2fduzqyb 472 10 of of IN cord-023726-2fduzqyb 472 11 a a DT cord-023726-2fduzqyb 472 12 stable stable JJ cord-023726-2fduzqyb 472 13 complex complex NN cord-023726-2fduzqyb 472 14 that that WDT cord-023726-2fduzqyb 472 15 consists consist VBZ cord-023726-2fduzqyb 472 16 of of IN cord-023726-2fduzqyb 472 17 six six CD cord-023726-2fduzqyb 472 18 capsid capsid NN cord-023726-2fduzqyb 472 19 protein protein NN cord-023726-2fduzqyb 472 20 molecules molecule NNS cord-023726-2fduzqyb 472 21 bound bind VBN cord-023726-2fduzqyb 472 22 to to IN cord-023726-2fduzqyb 472 23 a a DT cord-023726-2fduzqyb 472 24 specific specific JJ cord-023726-2fduzqyb 472 25 encapsidation encapsidation NN cord-023726-2fduzqyb 472 26 signal signal NN cord-023726-2fduzqyb 472 27 in in IN cord-023726-2fduzqyb 472 28 the the DT cord-023726-2fduzqyb 472 29 viral viral JJ cord-023726-2fduzqyb 472 30 RNA RNA NNP cord-023726-2fduzqyb 472 31 . . . cord-023726-2fduzqyb 473 1 Additional additional JJ cord-023726-2fduzqyb 473 2 capsid capsid NN cord-023726-2fduzqyb 473 3 protein protein NN cord-023726-2fduzqyb 473 4 dimers dimer NNS cord-023726-2fduzqyb 473 5 are be VBP cord-023726-2fduzqyb 473 6 then then RB cord-023726-2fduzqyb 473 7 recruited recruit VBN cord-023726-2fduzqyb 473 8 into into IN cord-023726-2fduzqyb 473 9 the the DT cord-023726-2fduzqyb 473 10 complex complex NN cord-023726-2fduzqyb 473 11 until until IN cord-023726-2fduzqyb 473 12 the the DT cord-023726-2fduzqyb 473 13 structure structure NN cord-023726-2fduzqyb 473 14 is be VBZ cord-023726-2fduzqyb 473 15 complete complete JJ cord-023726-2fduzqyb 473 16 . . . cord-023726-2fduzqyb 474 1 It -PRON- PRP cord-023726-2fduzqyb 474 2 is be VBZ cord-023726-2fduzqyb 474 3 probable probable JJ cord-023726-2fduzqyb 474 4 that that IN cord-023726-2fduzqyb 474 5 most most JJS cord-023726-2fduzqyb 474 6 other other JJ cord-023726-2fduzqyb 474 7 viruses virus NNS cord-023726-2fduzqyb 474 8 assemble assemble VBP cord-023726-2fduzqyb 474 9 in in IN cord-023726-2fduzqyb 474 10 a a DT cord-023726-2fduzqyb 474 11 manner manner NN cord-023726-2fduzqyb 474 12 similar similar JJ cord-023726-2fduzqyb 474 13 to to IN cord-023726-2fduzqyb 474 14 these these DT cord-023726-2fduzqyb 474 15 two two CD cord-023726-2fduzqyb 474 16 well well RB cord-023726-2fduzqyb 474 17 - - HYPH cord-023726-2fduzqyb 474 18 studied study VBN cord-023726-2fduzqyb 474 19 examples example NNS cord-023726-2fduzqyb 474 20 . . . cord-023726-2fduzqyb 475 1 At at IN cord-023726-2fduzqyb 475 2 least least JJS cord-023726-2fduzqyb 475 3 some some DT cord-023726-2fduzqyb 475 4 viruses virus NNS cord-023726-2fduzqyb 475 5 deviate deviate VBP cord-023726-2fduzqyb 475 6 from from IN cord-023726-2fduzqyb 475 7 this this DT cord-023726-2fduzqyb 475 8 model model NN cord-023726-2fduzqyb 475 9 , , , cord-023726-2fduzqyb 475 10 however however RB cord-023726-2fduzqyb 475 11 , , , cord-023726-2fduzqyb 475 12 and and CC cord-023726-2fduzqyb 475 13 assemble assemble VB cord-023726-2fduzqyb 475 14 an an DT cord-023726-2fduzqyb 475 15 empty empty JJ cord-023726-2fduzqyb 475 16 particle particle NN cord-023726-2fduzqyb 475 17 into into IN cord-023726-2fduzqyb 475 18 which which WDT cord-023726-2fduzqyb 475 19 the the DT cord-023726-2fduzqyb 475 20 viral viral JJ cord-023726-2fduzqyb 475 21 genome genome NN cord-023726-2fduzqyb 475 22 is be VBZ cord-023726-2fduzqyb 475 23 later later RB cord-023726-2fduzqyb 475 24 recruited recruit VBN cord-023726-2fduzqyb 475 25 . . . cord-023726-2fduzqyb 476 1 It -PRON- PRP cord-023726-2fduzqyb 476 2 is be VBZ cord-023726-2fduzqyb 476 3 also also RB cord-023726-2fduzqyb 476 4 known know VBN cord-023726-2fduzqyb 476 5 that that IN cord-023726-2fduzqyb 476 6 many many JJ cord-023726-2fduzqyb 476 7 viruses virus NNS cord-023726-2fduzqyb 476 8 will will MD cord-023726-2fduzqyb 476 9 assemble assemble VB cord-023726-2fduzqyb 476 10 empty empty JJ cord-023726-2fduzqyb 476 11 particles particle NNS cord-023726-2fduzqyb 476 12 if if IN cord-023726-2fduzqyb 476 13 the the DT cord-023726-2fduzqyb 476 14 structural structural JJ cord-023726-2fduzqyb 476 15 proteins protein NNS cord-023726-2fduzqyb 476 16 are be VBP cord-023726-2fduzqyb 476 17 expressed express VBN cord-023726-2fduzqyb 476 18 in in IN cord-023726-2fduzqyb 476 19 large large JJ cord-023726-2fduzqyb 476 20 amounts amount NNS cord-023726-2fduzqyb 476 21 in in IN cord-023726-2fduzqyb 476 22 the the DT cord-023726-2fduzqyb 476 23 absence absence NN cord-023726-2fduzqyb 476 24 of of IN cord-023726-2fduzqyb 476 25 viral viral JJ cord-023726-2fduzqyb 476 26 genomes genome NNS cord-023726-2fduzqyb 476 27 , , , cord-023726-2fduzqyb 476 28 even even RB cord-023726-2fduzqyb 476 29 if if IN cord-023726-2fduzqyb 476 30 assembly assembly NN cord-023726-2fduzqyb 476 31 is be VBZ cord-023726-2fduzqyb 476 32 normally normally RB cord-023726-2fduzqyb 476 33 coincident coincident JJ cord-023726-2fduzqyb 476 34 with with IN cord-023726-2fduzqyb 476 35 encapsidation encapsidation NN cord-023726-2fduzqyb 476 36 of of IN cord-023726-2fduzqyb 476 37 the the DT cord-023726-2fduzqyb 476 38 viral viral JJ cord-023726-2fduzqyb 476 39 genome genome NN cord-023726-2fduzqyb 476 40 in in IN cord-023726-2fduzqyb 476 41 infected infected JJ cord-023726-2fduzqyb 476 42 cells cell NNS cord-023726-2fduzqyb 476 43 . . . cord-023726-2fduzqyb 477 1 The the DT cord-023726-2fduzqyb 477 2 nucleocapsids nucleocapsid NNS cord-023726-2fduzqyb 477 3 of of IN cord-023726-2fduzqyb 477 4 most most RBS cord-023726-2fduzqyb 477 5 enveloped envelop VBN cord-023726-2fduzqyb 477 6 viruses virus NNS cord-023726-2fduzqyb 477 7 form form VBP cord-023726-2fduzqyb 477 8 within within IN cord-023726-2fduzqyb 477 9 the the DT cord-023726-2fduzqyb 477 10 cell cell NN cord-023726-2fduzqyb 477 11 by by IN cord-023726-2fduzqyb 477 12 pathways pathway NNS cord-023726-2fduzqyb 477 13 assumed assume VBN cord-023726-2fduzqyb 477 14 to to TO cord-023726-2fduzqyb 477 15 be be VB cord-023726-2fduzqyb 477 16 similar similar JJ cord-023726-2fduzqyb 477 17 to to IN cord-023726-2fduzqyb 477 18 those those DT cord-023726-2fduzqyb 477 19 described describe VBN cord-023726-2fduzqyb 477 20 above above RB cord-023726-2fduzqyb 477 21 . . . cord-023726-2fduzqyb 478 1 They -PRON- PRP cord-023726-2fduzqyb 478 2 can can MD cord-023726-2fduzqyb 478 3 often often RB cord-023726-2fduzqyb 478 4 be be VB cord-023726-2fduzqyb 478 5 isolated isolate VBN cord-023726-2fduzqyb 478 6 from from IN cord-023726-2fduzqyb 478 7 infected infected JJ cord-023726-2fduzqyb 478 8 cells cell NNS cord-023726-2fduzqyb 478 9 , , , cord-023726-2fduzqyb 478 10 and and CC cord-023726-2fduzqyb 478 11 for for IN cord-023726-2fduzqyb 478 12 many many JJ cord-023726-2fduzqyb 478 13 viruses virus NNS cord-023726-2fduzqyb 478 14 the the DT cord-023726-2fduzqyb 478 15 assembly assembly NNP cord-023726-2fduzqyb 478 16 of of IN cord-023726-2fduzqyb 478 17 nucleocapsids nucleocapsids NNP cord-023726-2fduzqyb 478 18 does do VBZ cord-023726-2fduzqyb 478 19 not not RB cord-023726-2fduzqyb 478 20 require require VB cord-023726-2fduzqyb 478 21 viral viral JJ cord-023726-2fduzqyb 478 22 budding bud VBG cord-023726-2fduzqyb 478 23 or or CC cord-023726-2fduzqyb 478 24 even even RB cord-023726-2fduzqyb 478 25 the the DT cord-023726-2fduzqyb 478 26 expression expression NN cord-023726-2fduzqyb 478 27 of of IN cord-023726-2fduzqyb 478 28 viral viral JJ cord-023726-2fduzqyb 478 29 surface surface NN cord-023726-2fduzqyb 478 30 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 478 31 . . . cord-023726-2fduzqyb 479 1 After after IN cord-023726-2fduzqyb 479 2 assembly assembly NN cord-023726-2fduzqyb 479 3 , , , cord-023726-2fduzqyb 479 4 the the DT cord-023726-2fduzqyb 479 5 nucleocapsids nucleocapsids NNP cord-023726-2fduzqyb 479 6 bud bud NN cord-023726-2fduzqyb 479 7 through through IN cord-023726-2fduzqyb 479 8 a a DT cord-023726-2fduzqyb 479 9 cellular cellular JJ cord-023726-2fduzqyb 479 10 membrane membrane NN cord-023726-2fduzqyb 479 11 , , , cord-023726-2fduzqyb 479 12 which which WDT cord-023726-2fduzqyb 479 13 contains contain VBZ cord-023726-2fduzqyb 479 14 viral viral JJ cord-023726-2fduzqyb 479 15 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 479 16 , , , cord-023726-2fduzqyb 479 17 to to TO cord-023726-2fduzqyb 479 18 acquire acquire VB cord-023726-2fduzqyb 479 19 their -PRON- PRP$ cord-023726-2fduzqyb 479 20 envelope envelope NN cord-023726-2fduzqyb 479 21 . . . cord-023726-2fduzqyb 480 1 Budding bud VBG cord-023726-2fduzqyb 480 2 retroviruses retrovirus NNS cord-023726-2fduzqyb 480 3 were be VBD cord-023726-2fduzqyb 480 4 illustrated illustrate VBN cord-023726-2fduzqyb 480 5 in in IN cord-023726-2fduzqyb 480 6 Fig Fig NNP cord-023726-2fduzqyb 480 7 . . . cord-023726-2fduzqyb 481 1 2 2 LS cord-023726-2fduzqyb 481 2 .21 .21 CD cord-023726-2fduzqyb 481 3 and and CC cord-023726-2fduzqyb 481 4 budding bud VBG cord-023726-2fduzqyb 481 5 rhabdoviruses rhabdovirus NNS cord-023726-2fduzqyb 481 6 in in IN cord-023726-2fduzqyb 481 7 Fig Fig NNP cord-023726-2fduzqyb 481 8 . . . cord-023726-2fduzqyb 482 1 2 2 LS cord-023726-2fduzqyb 482 2 .23 .23 NFP cord-023726-2fduzqyb 482 3 . . . cord-023726-2fduzqyb 483 1 A a DT cord-023726-2fduzqyb 483 2 gallery gallery NN cord-023726-2fduzqyb 483 3 of of IN cord-023726-2fduzqyb 483 4 budding bud VBG cord-023726-2fduzqyb 483 5 viruses virus NNS cord-023726-2fduzqyb 483 6 belonging belong VBG cord-023726-2fduzqyb 483 7 to to IN cord-023726-2fduzqyb 483 8 other other JJ cord-023726-2fduzqyb 483 9 families family NNS cord-023726-2fduzqyb 483 10 is be VBZ cord-023726-2fduzqyb 483 11 shown show VBN cord-023726-2fduzqyb 483 12 in in IN cord-023726-2fduzqyb 483 13 Fig Fig NNP cord-023726-2fduzqyb 483 14 . . . cord-023726-2fduzqyb 484 1 2 2 LS cord-023726-2fduzqyb 484 2 .25 .25 NFP cord-023726-2fduzqyb 484 3 . . . cord-023726-2fduzqyb 485 1 The the DT cord-023726-2fduzqyb 485 2 membrane membrane NN cord-023726-2fduzqyb 485 3 chosen choose VBN cord-023726-2fduzqyb 485 4 for for IN cord-023726-2fduzqyb 485 5 budding bud VBG cord-023726-2fduzqyb 485 6 depends depend VBZ cord-023726-2fduzqyb 485 7 on on IN cord-023726-2fduzqyb 485 8 the the DT cord-023726-2fduzqyb 485 9 virus virus NN cord-023726-2fduzqyb 485 10 and and CC cord-023726-2fduzqyb 485 11 depends depend VBZ cord-023726-2fduzqyb 485 12 , , , cord-023726-2fduzqyb 485 13 in in IN cord-023726-2fduzqyb 485 14 part part NN cord-023726-2fduzqyb 485 15 if if IN cord-023726-2fduzqyb 485 16 not not RB cord-023726-2fduzqyb 485 17 entirely entirely RB cord-023726-2fduzqyb 485 18 , , , cord-023726-2fduzqyb 485 19 on on IN cord-023726-2fduzqyb 485 20 the the DT cord-023726-2fduzqyb 485 21 membrane membrane NN cord-023726-2fduzqyb 485 22 to to TO cord-023726-2fduzqyb 485 23 which which WDT cord-023726-2fduzqyb 485 24 the the DT cord-023726-2fduzqyb 485 25 viral viral JJ cord-023726-2fduzqyb 485 26 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 485 27 are be VBP cord-023726-2fduzqyb 485 28 directed direct VBN cord-023726-2fduzqyb 485 29 by by IN cord-023726-2fduzqyb 485 30 signals signal NNS cord-023726-2fduzqyb 485 31 within within IN cord-023726-2fduzqyb 485 32 those those DT cord-023726-2fduzqyb 485 33 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 485 34 . . . cord-023726-2fduzqyb 486 1 Many many JJ cord-023726-2fduzqyb 486 2 viruses virus NNS cord-023726-2fduzqyb 486 3 bud bud VBP cord-023726-2fduzqyb 486 4 through through IN cord-023726-2fduzqyb 486 5 the the DT cord-023726-2fduzqyb 486 6 cell cell NN cord-023726-2fduzqyb 486 7 plasma plasma NN cord-023726-2fduzqyb 486 8 membrane membrane NN cord-023726-2fduzqyb 486 9 ( ( -LRB- cord-023726-2fduzqyb 486 10 Figs fig NNS cord-023726-2fduzqyb 486 11 . . . cord-023726-2fduzqyb 487 1 2.25B 2.25b CD cord-023726-2fduzqyb 487 2 - - HYPH cord-023726-2fduzqyb 487 3 F F NNP cord-023726-2fduzqyb 487 4 ) ) -RRB- cord-023726-2fduzqyb 487 5 ; ; : cord-023726-2fduzqyb 487 6 in in IN cord-023726-2fduzqyb 487 7 polarized polarized JJ cord-023726-2fduzqyb 487 8 cells cell NNS cord-023726-2fduzqyb 487 9 , , , cord-023726-2fduzqyb 487 10 only only RB cord-023726-2fduzqyb 487 11 one one CD cord-023726-2fduzqyb 487 12 side side NN cord-023726-2fduzqyb 487 13 of of IN cord-023726-2fduzqyb 487 14 the the DT cord-023726-2fduzqyb 487 15 cell cell NN cord-023726-2fduzqyb 487 16 may may MD cord-023726-2fduzqyb 487 17 be be VB cord-023726-2fduzqyb 487 18 used use VBN cord-023726-2fduzqyb 487 19 . . . cord-023726-2fduzqyb 488 1 Other other JJ cord-023726-2fduzqyb 488 2 viruses virus NNS cord-023726-2fduzqyb 488 3 , , , cord-023726-2fduzqyb 488 4 such such JJ cord-023726-2fduzqyb 488 5 as as IN cord-023726-2fduzqyb 488 6 the the DT cord-023726-2fduzqyb 488 7 coronaviruses coronaviruse NNS cord-023726-2fduzqyb 488 8 and and CC cord-023726-2fduzqyb 488 9 the the DT cord-023726-2fduzqyb 488 10 bunyaviruses bunyavirus NNS cord-023726-2fduzqyb 488 11 , , , cord-023726-2fduzqyb 488 12 use use VB cord-023726-2fduzqyb 488 13 the the DT cord-023726-2fduzqyb 488 14 endoplasmic endoplasmic NN cord-023726-2fduzqyb 488 15 reticulum reticulum NN cord-023726-2fduzqyb 488 16 or or CC cord-023726-2fduzqyb 488 17 other other JJ cord-023726-2fduzqyb 488 18 internal internal JJ cord-023726-2fduzqyb 488 19 membranes membrane NNS cord-023726-2fduzqyb 488 20 . . . cord-023726-2fduzqyb 489 1 The the DT cord-023726-2fduzqyb 489 2 herpesviruses herpesviruse NNS cord-023726-2fduzqyb 489 3 replicate replicate VBP cord-023726-2fduzqyb 489 4 in in IN cord-023726-2fduzqyb 489 5 the the DT cord-023726-2fduzqyb 489 6 nucleus nucleus NN cord-023726-2fduzqyb 489 7 and and CC cord-023726-2fduzqyb 489 8 the the DT cord-023726-2fduzqyb 489 9 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 489 10 assembles assemble VBZ cord-023726-2fduzqyb 489 11 in in IN cord-023726-2fduzqyb 489 12 the the DT cord-023726-2fduzqyb 489 13 nucleus nucleus NN cord-023726-2fduzqyb 489 14 ; ; : cord-023726-2fduzqyb 489 15 in in IN cord-023726-2fduzqyb 489 16 this this DT cord-023726-2fduzqyb 489 17 case case NN cord-023726-2fduzqyb 489 18 , , , cord-023726-2fduzqyb 489 19 the the DT cord-023726-2fduzqyb 489 20 first first JJ cord-023726-2fduzqyb 489 21 budding budding JJ cord-023726-2fduzqyb 489 22 event event NN cord-023726-2fduzqyb 489 23 is be VBZ cord-023726-2fduzqyb 489 24 through through IN cord-023726-2fduzqyb 489 25 the the DT cord-023726-2fduzqyb 489 26 nuclear nuclear JJ cord-023726-2fduzqyb 489 27 membrane membrane NN cord-023726-2fduzqyb 489 28 ( ( -LRB- cord-023726-2fduzqyb 489 29 Fig Fig NNP cord-023726-2fduzqyb 489 30 . . . cord-023726-2fduzqyb 489 31 2.25A 2.25a CD cord-023726-2fduzqyb 489 32 ) ) -RRB- cord-023726-2fduzqyb 489 33 . . . cord-023726-2fduzqyb 490 1 Although although IN cord-023726-2fduzqyb 490 2 the the DT cord-023726-2fduzqyb 490 3 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 490 4 of of IN cord-023726-2fduzqyb 490 5 most most JJS cord-023726-2fduzqyb 490 6 enveloped envelop VBN cord-023726-2fduzqyb 490 7 viruses virus NNS cord-023726-2fduzqyb 490 8 assembles assemble VBZ cord-023726-2fduzqyb 490 9 independently independently RB cord-023726-2fduzqyb 490 10 within within IN cord-023726-2fduzqyb 490 11 the the DT cord-023726-2fduzqyb 490 12 cell cell NN cord-023726-2fduzqyb 490 13 and and CC cord-023726-2fduzqyb 490 14 then then RB cord-023726-2fduzqyb 490 15 buds bud NNS cord-023726-2fduzqyb 490 16 to to TO cord-023726-2fduzqyb 490 17 acquire acquire VB cord-023726-2fduzqyb 490 18 an an DT cord-023726-2fduzqyb 490 19 envelope envelope NN cord-023726-2fduzqyb 490 20 , , , cord-023726-2fduzqyb 490 21 exceptions exception NNS cord-023726-2fduzqyb 490 22 are be VBP cord-023726-2fduzqyb 490 23 known know VBN cord-023726-2fduzqyb 490 24 . . . cord-023726-2fduzqyb 491 1 The the DT cord-023726-2fduzqyb 491 2 example example NN cord-023726-2fduzqyb 491 3 of of IN cord-023726-2fduzqyb 491 4 retroviruses retrovirus NNS cord-023726-2fduzqyb 491 5 , , , cord-023726-2fduzqyb 491 6 some some DT cord-023726-2fduzqyb 491 7 of of IN cord-023726-2fduzqyb 491 8 which which WDT cord-023726-2fduzqyb 491 9 assemble assemble VBP cord-023726-2fduzqyb 491 10 a a DT cord-023726-2fduzqyb 491 11 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 491 12 during during IN cord-023726-2fduzqyb 491 13 virus virus NN cord-023726-2fduzqyb 491 14 budding budding NN cord-023726-2fduzqyb 491 15 , , , cord-023726-2fduzqyb 491 16 was be VBD cord-023726-2fduzqyb 491 17 discussed discuss VBN cord-023726-2fduzqyb 491 18 earlier early RBR cord-023726-2fduzqyb 491 19 . . . cord-023726-2fduzqyb 492 1 In in IN cord-023726-2fduzqyb 492 2 these these DT cord-023726-2fduzqyb 492 3 viruses virus NNS cord-023726-2fduzqyb 492 4 , , , cord-023726-2fduzqyb 492 5 morphogenesis morphogenesis NN cord-023726-2fduzqyb 492 6 is be VBZ cord-023726-2fduzqyb 492 7 a a DT cord-023726-2fduzqyb 492 8 coordinated coordinated JJ cord-023726-2fduzqyb 492 9 event event NN cord-023726-2fduzqyb 492 10 . . . cord-023726-2fduzqyb 493 1 The the DT cord-023726-2fduzqyb 493 2 forces force NNS cord-023726-2fduzqyb 493 3 that that WDT cord-023726-2fduzqyb 493 4 result result VBP cord-023726-2fduzqyb 493 5 in in IN cord-023726-2fduzqyb 493 6 virus virus NN cord-023726-2fduzqyb 493 7 budding bud VBG cord-023726-2fduzqyb 493 8 are be VBP cord-023726-2fduzqyb 493 9 not not RB cord-023726-2fduzqyb 493 10 well well RB cord-023726-2fduzqyb 493 11 understood understand VBN cord-023726-2fduzqyb 493 12 for for IN cord-023726-2fduzqyb 493 13 most most JJS cord-023726-2fduzqyb 493 14 enveloped envelop VBN cord-023726-2fduzqyb 493 15 viruses virus NNS cord-023726-2fduzqyb 493 16 . . . cord-023726-2fduzqyb 494 1 In in IN cord-023726-2fduzqyb 494 2 the the DT cord-023726-2fduzqyb 494 3 case case NN cord-023726-2fduzqyb 494 4 of of IN cord-023726-2fduzqyb 494 5 the the DT cord-023726-2fduzqyb 494 6 alphaviruses alphavirus NNS cord-023726-2fduzqyb 494 7 , , , cord-023726-2fduzqyb 494 8 there there EX cord-023726-2fduzqyb 494 9 is be VBZ cord-023726-2fduzqyb 494 10 evidence evidence NN cord-023726-2fduzqyb 494 11 for for IN cord-023726-2fduzqyb 494 12 specific specific JJ cord-023726-2fduzqyb 494 13 interactions interaction NNS cord-023726-2fduzqyb 494 14 between between IN cord-023726-2fduzqyb 494 15 the the DT cord-023726-2fduzqyb 494 16 cytoplasmic cytoplasmic JJ cord-023726-2fduzqyb 494 17 domains domain NNS cord-023726-2fduzqyb 494 18 of of IN cord-023726-2fduzqyb 494 19 the the DT cord-023726-2fduzqyb 494 20 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 494 21 and and CC cord-023726-2fduzqyb 494 22 binding bind VBG cord-023726-2fduzqyb 494 23 sites site NNS cord-023726-2fduzqyb 494 24 on on IN cord-023726-2fduzqyb 494 25 the the DT cord-023726-2fduzqyb 494 26 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 494 27 proteins protein NNS cord-023726-2fduzqyb 494 28 . . . cord-023726-2fduzqyb 495 1 The the DT cord-023726-2fduzqyb 495 2 model model NN cord-023726-2fduzqyb 495 3 for for IN cord-023726-2fduzqyb 495 4 budding bud VBG cord-023726-2fduzqyb 495 5 of of IN cord-023726-2fduzqyb 495 6 these these DT cord-023726-2fduzqyb 495 7 viruses virus NNS cord-023726-2fduzqyb 495 8 is be VBZ cord-023726-2fduzqyb 495 9 that that IN cord-023726-2fduzqyb 495 10 the the DT cord-023726-2fduzqyb 495 11 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 495 12 first first RB cord-023726-2fduzqyb 495 13 binds bind VBZ cord-023726-2fduzqyb 495 14 to to IN cord-023726-2fduzqyb 495 15 one one CD cord-023726-2fduzqyb 495 16 or or CC cord-023726-2fduzqyb 495 17 a a DT cord-023726-2fduzqyb 495 18 few few JJ cord-023726-2fduzqyb 495 19 glycoprotein glycoprotein NN cord-023726-2fduzqyb 495 20 heterodimers heterodimer NNS cord-023726-2fduzqyb 495 21 at at IN cord-023726-2fduzqyb 495 22 the the DT cord-023726-2fduzqyb 495 23 plasma plasma NN cord-023726-2fduzqyb 495 24 membrane membrane NN cord-023726-2fduzqyb 495 25 . . . cord-023726-2fduzqyb 496 1 By by IN cord-023726-2fduzqyb 496 2 a a DT cord-023726-2fduzqyb 496 3 process process NN cord-023726-2fduzqyb 496 4 of of IN cord-023726-2fduzqyb 496 5 lateral lateral JJ cord-023726-2fduzqyb 496 6 diffusion diffusion NN cord-023726-2fduzqyb 496 7 , , , cord-023726-2fduzqyb 496 8 additional additional JJ cord-023726-2fduzqyb 496 9 glycoprotein glycoprotein NN cord-023726-2fduzqyb 496 10 heterodimers heterodimer NNS cord-023726-2fduzqyb 496 11 move move VBP cord-023726-2fduzqyb 496 12 in in RB cord-023726-2fduzqyb 496 13 and and CC cord-023726-2fduzqyb 496 14 are be VBP cord-023726-2fduzqyb 496 15 bound bind VBN cord-023726-2fduzqyb 496 16 until until IN cord-023726-2fduzqyb 496 17 a a DT cord-023726-2fduzqyb 496 18 full full JJ cord-023726-2fduzqyb 496 19 complement complement NN cord-023726-2fduzqyb 496 20 is be VBZ cord-023726-2fduzqyb 496 21 achieved achieve VBN cord-023726-2fduzqyb 496 22 and and CC cord-023726-2fduzqyb 496 23 the the DT cord-023726-2fduzqyb 496 24 virus virus NN cord-023726-2fduzqyb 496 25 is be VBZ cord-023726-2fduzqyb 496 26 now now RB cord-023726-2fduzqyb 496 27 outside outside IN cord-023726-2fduzqyb 496 28 the the DT cord-023726-2fduzqyb 496 29 cell cell NN cord-023726-2fduzqyb 496 30 . . . cord-023726-2fduzqyb 497 1 Additional additional JJ cord-023726-2fduzqyb 497 2 free free JJ cord-023726-2fduzqyb 497 3 energy energy NN cord-023726-2fduzqyb 497 4 for for IN cord-023726-2fduzqyb 497 5 budding bud VBG cord-023726-2fduzqyb 497 6 is be VBZ cord-023726-2fduzqyb 497 7 furnished furnish VBN cord-023726-2fduzqyb 497 8 by by IN cord-023726-2fduzqyb 497 9 lateral lateral JJ cord-023726-2fduzqyb 497 10 interactions interaction NNS cord-023726-2fduzqyb 497 11 between between IN cord-023726-2fduzqyb 497 12 the the DT cord-023726-2fduzqyb 497 13 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 497 14 , , , cord-023726-2fduzqyb 497 15 which which WDT cord-023726-2fduzqyb 497 16 form form VBP cord-023726-2fduzqyb 497 17 a a DT cord-023726-2fduzqyb 497 18 contiguous contiguous JJ cord-023726-2fduzqyb 497 19 layer layer NN cord-023726-2fduzqyb 497 20 on on IN cord-023726-2fduzqyb 497 21 the the DT cord-023726-2fduzqyb 497 22 surface surface NN cord-023726-2fduzqyb 497 23 ( ( -LRB- cord-023726-2fduzqyb 497 24 Fig Fig NNP cord-023726-2fduzqyb 497 25 . . . cord-023726-2fduzqyb 497 26 2.18C 2.18c CD cord-023726-2fduzqyb 497 27 ) ) -RRB- cord-023726-2fduzqyb 497 28 . . . cord-023726-2fduzqyb 498 1 This this DT cord-023726-2fduzqyb 498 2 model model NN cord-023726-2fduzqyb 498 3 accounts account VBZ cord-023726-2fduzqyb 498 4 for for IN cord-023726-2fduzqyb 498 5 the the DT cord-023726-2fduzqyb 498 6 regularity regularity NN cord-023726-2fduzqyb 498 7 of of IN cord-023726-2fduzqyb 498 8 the the DT cord-023726-2fduzqyb 498 9 virion virion NN cord-023726-2fduzqyb 498 10 , , , cord-023726-2fduzqyb 498 11 the the DT cord-023726-2fduzqyb 498 12 one one CD cord-023726-2fduzqyb 498 13 - - HYPH cord-023726-2fduzqyb 498 14 to to IN cord-023726-2fduzqyb 498 15 - - HYPH cord-023726-2fduzqyb 498 16 one one CD cord-023726-2fduzqyb 498 17 ratio ratio NN cord-023726-2fduzqyb 498 18 of of IN cord-023726-2fduzqyb 498 19 the the DT cord-023726-2fduzqyb 498 20 structural structural JJ cord-023726-2fduzqyb 498 21 proteins protein NNS cord-023726-2fduzqyb 498 22 in in IN cord-023726-2fduzqyb 498 23 the the DT cord-023726-2fduzqyb 498 24 virion virion NN cord-023726-2fduzqyb 498 25 , , , cord-023726-2fduzqyb 498 26 and and CC cord-023726-2fduzqyb 498 27 the the DT cord-023726-2fduzqyb 498 28 requirement requirement NN cord-023726-2fduzqyb 498 29 of of IN cord-023726-2fduzqyb 498 30 the the DT cord-023726-2fduzqyb 498 31 virus virus NN cord-023726-2fduzqyb 498 32 for for IN cord-023726-2fduzqyb 498 33 its -PRON- PRP$ cord-023726-2fduzqyb 498 34 own own JJ cord-023726-2fduzqyb 498 35 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 498 36 in in IN cord-023726-2fduzqyb 498 37 order order NN cord-023726-2fduzqyb 498 38 to to IN cord-023726-2fduzqyb 498 39 bud bud NN cord-023726-2fduzqyb 498 40 . . . cord-023726-2fduzqyb 499 1 In in IN cord-023726-2fduzqyb 499 2 other other JJ cord-023726-2fduzqyb 499 3 enveloped envelop VBN cord-023726-2fduzqyb 499 4 viruses virus NNS cord-023726-2fduzqyb 499 5 , , , cord-023726-2fduzqyb 499 6 however however RB cord-023726-2fduzqyb 499 7 , , , cord-023726-2fduzqyb 499 8 there there EX cord-023726-2fduzqyb 499 9 is be VBZ cord-023726-2fduzqyb 499 10 little little JJ cord-023726-2fduzqyb 499 11 evidence evidence NN cord-023726-2fduzqyb 499 12 for for IN cord-023726-2fduzqyb 499 13 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 499 14 - - HYPH cord-023726-2fduzqyb 499 15 glycoprotein glycoprotein NN cord-023726-2fduzqyb 499 16 interactions interaction NNS cord-023726-2fduzqyb 499 17 . . . cord-023726-2fduzqyb 500 1 The the DT cord-023726-2fduzqyb 500 2 protein protein NN cord-023726-2fduzqyb 500 3 composition composition NN cord-023726-2fduzqyb 500 4 of of IN cord-023726-2fduzqyb 500 5 the the DT cord-023726-2fduzqyb 500 6 virion virion NN cord-023726-2fduzqyb 500 7 is be VBZ cord-023726-2fduzqyb 500 8 usually usually RB cord-023726-2fduzqyb 500 9 not not RB cord-023726-2fduzqyb 500 10 fixed fix VBN cord-023726-2fduzqyb 500 11 , , , cord-023726-2fduzqyb 500 12 but but CC cord-023726-2fduzqyb 500 13 can can MD cord-023726-2fduzqyb 500 14 vary vary VB cord-023726-2fduzqyb 500 15 within within IN cord-023726-2fduzqyb 500 16 limits limit NNS cord-023726-2fduzqyb 500 17 . . . cord-023726-2fduzqyb 501 1 In in IN cord-023726-2fduzqyb 501 2 fact fact NN cord-023726-2fduzqyb 501 3 , , , cord-023726-2fduzqyb 501 4 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 501 5 from from IN cord-023726-2fduzqyb 501 6 unrelated unrelated JJ cord-023726-2fduzqyb 501 7 viruses virus NNS cord-023726-2fduzqyb 501 8 can can MD cord-023726-2fduzqyb 501 9 often often RB cord-023726-2fduzqyb 501 10 be be VB cord-023726-2fduzqyb 501 11 substituted substitute VBN cord-023726-2fduzqyb 501 12 . . . cord-023726-2fduzqyb 502 1 In in IN cord-023726-2fduzqyb 502 2 the the DT cord-023726-2fduzqyb 502 3 extreme extreme JJ cord-023726-2fduzqyb 502 4 case case NN cord-023726-2fduzqyb 502 5 of of IN cord-023726-2fduzqyb 502 6 retroviruses retrovirus NNS cord-023726-2fduzqyb 502 7 , , , cord-023726-2fduzqyb 502 8 noninfectious noninfectious JJ cord-023726-2fduzqyb 502 9 virus virus NN cord-023726-2fduzqyb 502 10 particles particle NNS cord-023726-2fduzqyb 502 11 will will MD cord-023726-2fduzqyb 502 12 form form VB cord-023726-2fduzqyb 502 13 that that WDT cord-023726-2fduzqyb 502 14 are be VBP cord-023726-2fduzqyb 502 15 completely completely RB cord-023726-2fduzqyb 502 16 devoid devoid JJ cord-023726-2fduzqyb 502 17 of of IN cord-023726-2fduzqyb 502 18 glycoprotein glycoprotein NN cord-023726-2fduzqyb 502 19 . . . cord-023726-2fduzqyb 503 1 The the DT cord-023726-2fduzqyb 503 2 matrix matrix NN cord-023726-2fduzqyb 503 3 proteins protein NNS cord-023726-2fduzqyb 503 4 appear appear VBP cord-023726-2fduzqyb 503 5 to to TO cord-023726-2fduzqyb 503 6 play play VB cord-023726-2fduzqyb 503 7 a a DT cord-023726-2fduzqyb 503 8 key key JJ cord-023726-2fduzqyb 503 9 role role NN cord-023726-2fduzqyb 503 10 in in IN cord-023726-2fduzqyb 503 11 the the DT cord-023726-2fduzqyb 503 12 budding budding NN cord-023726-2fduzqyb 503 13 process process NN cord-023726-2fduzqyb 503 14 , , , cord-023726-2fduzqyb 503 15 as as IN cord-023726-2fduzqyb 503 16 do do VBP cord-023726-2fduzqyb 503 17 other other JJ cord-023726-2fduzqyb 503 18 protein protein NN cord-023726-2fduzqyb 503 19 - - HYPH cord-023726-2fduzqyb 503 20 protein protein NN cord-023726-2fduzqyb 503 21 interactions interaction NNS cord-023726-2fduzqyb 503 22 that that WDT cord-023726-2fduzqyb 503 23 are be VBP cord-023726-2fduzqyb 503 24 yet yet RB cord-023726-2fduzqyb 503 25 to to TO cord-023726-2fduzqyb 503 26 be be VB cord-023726-2fduzqyb 503 27 determined determine VBN cord-023726-2fduzqyb 503 28 . . . cord-023726-2fduzqyb 504 1 For for IN cord-023726-2fduzqyb 504 2 most most JJS cord-023726-2fduzqyb 504 3 animal animal NN cord-023726-2fduzqyb 504 4 viruses virus NNS cord-023726-2fduzqyb 504 5 , , , cord-023726-2fduzqyb 504 6 there there EX cord-023726-2fduzqyb 504 7 are be VBP cord-023726-2fduzqyb 504 8 one one CD cord-023726-2fduzqyb 504 9 or or CC cord-023726-2fduzqyb 504 10 more more JJR cord-023726-2fduzqyb 504 11 cleavages cleavage NNS cord-023726-2fduzqyb 504 12 in in IN cord-023726-2fduzqyb 504 13 structural structural JJ cord-023726-2fduzqyb 504 14 protein protein NN cord-023726-2fduzqyb 504 15 precursors precursor NNS cord-023726-2fduzqyb 504 16 during during IN cord-023726-2fduzqyb 504 17 assembly assembly NN cord-023726-2fduzqyb 504 18 of of IN cord-023726-2fduzqyb 504 19 virions virion NNS cord-023726-2fduzqyb 504 20 that that WDT cord-023726-2fduzqyb 504 21 are be VBP cord-023726-2fduzqyb 504 22 required require VBN cord-023726-2fduzqyb 504 23 to to TO cord-023726-2fduzqyb 504 24 activate activate VB cord-023726-2fduzqyb 504 25 the the DT cord-023726-2fduzqyb 504 26 infectivity infectivity NN cord-023726-2fduzqyb 504 27 of of IN cord-023726-2fduzqyb 504 28 the the DT cord-023726-2fduzqyb 504 29 virion virion NN cord-023726-2fduzqyb 504 30 . . . cord-023726-2fduzqyb 505 1 Interestingly interestingly RB cord-023726-2fduzqyb 505 2 , , , cord-023726-2fduzqyb 505 3 these these DT cord-023726-2fduzqyb 505 4 cleavages cleavage NNS cord-023726-2fduzqyb 505 5 may may MD cord-023726-2fduzqyb 505 6 either either CC cord-023726-2fduzqyb 505 7 stabilize stabilize VB cord-023726-2fduzqyb 505 8 or or CC cord-023726-2fduzqyb 505 9 destabilize destabilize VB cord-023726-2fduzqyb 505 10 the the DT cord-023726-2fduzqyb 505 11 virion virion NN cord-023726-2fduzqyb 505 12 in in IN cord-023726-2fduzqyb 505 13 the the DT cord-023726-2fduzqyb 505 14 extracellular extracellular JJ cord-023726-2fduzqyb 505 15 environment environment NN cord-023726-2fduzqyb 505 16 , , , cord-023726-2fduzqyb 505 17 depending depend VBG cord-023726-2fduzqyb 505 18 on on IN cord-023726-2fduzqyb 505 19 the the DT cord-023726-2fduzqyb 505 20 virus virus NN cord-023726-2fduzqyb 505 21 . . . cord-023726-2fduzqyb 506 1 Many many JJ cord-023726-2fduzqyb 506 2 of of IN cord-023726-2fduzqyb 506 3 these these DT cord-023726-2fduzqyb 506 4 cleavages cleavage NNS cord-023726-2fduzqyb 506 5 are be VBP cord-023726-2fduzqyb 506 6 effected effect VBN cord-023726-2fduzqyb 506 7 by by IN cord-023726-2fduzqyb 506 8 viral viral JJ cord-023726-2fduzqyb 506 9 proteases protease NNS cord-023726-2fduzqyb 506 10 , , , cord-023726-2fduzqyb 506 11 whereas whereas IN cord-023726-2fduzqyb 506 12 others other NNS cord-023726-2fduzqyb 506 13 are be VBP cord-023726-2fduzqyb 506 14 performed perform VBN cord-023726-2fduzqyb 506 15 by by IN cord-023726-2fduzqyb 506 16 cellular cellular JJ cord-023726-2fduzqyb 506 17 proteases protease NNS cord-023726-2fduzqyb 506 18 present present JJ cord-023726-2fduzqyb 506 19 in in IN cord-023726-2fduzqyb 506 20 subcellular subcellular JJ cord-023726-2fduzqyb 506 21 organelles organelle NNS cord-023726-2fduzqyb 506 22 . . . cord-023726-2fduzqyb 507 1 Virions virion NNS cord-023726-2fduzqyb 507 2 are be VBP cord-023726-2fduzqyb 507 3 formed form VBN cord-023726-2fduzqyb 507 4 by by IN cord-023726-2fduzqyb 507 5 the the DT cord-023726-2fduzqyb 507 6 spontaneous spontaneous JJ cord-023726-2fduzqyb 507 7 assembly assembly NNP cord-023726-2fduzqyb 507 8 of of IN cord-023726-2fduzqyb 507 9 components component NNS cord-023726-2fduzqyb 507 10 in in IN cord-023726-2fduzqyb 507 11 the the DT cord-023726-2fduzqyb 507 12 infected infected JJ cord-023726-2fduzqyb 507 13 cell cell NN cord-023726-2fduzqyb 507 14 , , , cord-023726-2fduzqyb 507 15 sometimes sometimes RB cord-023726-2fduzqyb 507 16 with with IN cord-023726-2fduzqyb 507 17 the the DT cord-023726-2fduzqyb 507 18 aid aid NN cord-023726-2fduzqyb 507 19 of of IN cord-023726-2fduzqyb 507 20 assembly assembly NN cord-023726-2fduzqyb 507 21 factors factor NNS cord-023726-2fduzqyb 507 22 ( ( -LRB- cord-023726-2fduzqyb 507 23 " " `` cord-023726-2fduzqyb 507 24 scaffolds scaffold NNS cord-023726-2fduzqyb 507 25 " " '' cord-023726-2fduzqyb 507 26 ) ) -RRB- cord-023726-2fduzqyb 507 27 that that WDT cord-023726-2fduzqyb 507 28 do do VBP cord-023726-2fduzqyb 507 29 not not RB cord-023726-2fduzqyb 507 30 form form VB cord-023726-2fduzqyb 507 31 components component NNS cord-023726-2fduzqyb 507 32 of of IN cord-023726-2fduzqyb 507 33 the the DT cord-023726-2fduzqyb 507 34 mature mature JJ cord-023726-2fduzqyb 507 35 virion virion NN cord-023726-2fduzqyb 507 36 . . . cord-023726-2fduzqyb 508 1 For for IN cord-023726-2fduzqyb 508 2 most most JJS cord-023726-2fduzqyb 508 3 nonenveloped nonenveloped JJ cord-023726-2fduzqyb 508 4 viruses virus NNS cord-023726-2fduzqyb 508 5 , , , cord-023726-2fduzqyb 508 6 complete complete JJ cord-023726-2fduzqyb 508 7 assembly assembly NN cord-023726-2fduzqyb 508 8 occurs occur VBZ cord-023726-2fduzqyb 508 9 within within IN cord-023726-2fduzqyb 508 10 the the DT cord-023726-2fduzqyb 508 11 cell cell NN cord-023726-2fduzqyb 508 12 cytoplasm cytoplasm NN cord-023726-2fduzqyb 508 13 or or CC cord-023726-2fduzqyb 508 14 nucleoplasm nucleoplasm NN cord-023726-2fduzqyb 508 15 . . . cord-023726-2fduzqyb 509 1 For for IN cord-023726-2fduzqyb 509 2 enveloped envelop VBN cord-023726-2fduzqyb 509 3 viruses virus NNS cord-023726-2fduzqyb 509 4 , , , cord-023726-2fduzqyb 509 5 final final JJ cord-023726-2fduzqyb 509 6 assembly assembly NN cord-023726-2fduzqyb 509 7 of of IN cord-023726-2fduzqyb 509 8 the the DT cord-023726-2fduzqyb 509 9 virus virus NN cord-023726-2fduzqyb 509 10 occurs occur VBZ cord-023726-2fduzqyb 509 11 by by IN cord-023726-2fduzqyb 509 12 budding bud VBG cord-023726-2fduzqyb 509 13 through through IN cord-023726-2fduzqyb 509 14 a a DT cord-023726-2fduzqyb 509 15 cellular cellular JJ cord-023726-2fduzqyb 509 16 membrane membrane NN cord-023726-2fduzqyb 509 17 . . . cord-023726-2fduzqyb 510 1 In in IN cord-023726-2fduzqyb 510 2 either either DT cord-023726-2fduzqyb 510 3 case case NN cord-023726-2fduzqyb 510 4 , , , cord-023726-2fduzqyb 510 5 the the DT cord-023726-2fduzqyb 510 6 virion virion NN cord-023726-2fduzqyb 510 7 must must MD cord-023726-2fduzqyb 510 8 subsequently subsequently RB cord-023726-2fduzqyb 510 9 disassemble disassemble VB cord-023726-2fduzqyb 510 10 spontaneously spontaneously RB cord-023726-2fduzqyb 510 11 on on IN cord-023726-2fduzqyb 510 12 infection infection NN cord-023726-2fduzqyb 510 13 of of IN cord-023726-2fduzqyb 510 14 a a DT cord-023726-2fduzqyb 510 15 new new JJ cord-023726-2fduzqyb 510 16 cell cell NN cord-023726-2fduzqyb 510 17 . . . cord-023726-2fduzqyb 511 1 The the DT cord-023726-2fduzqyb 511 2 cleavages cleavage NNS cord-023726-2fduzqyb 511 3 that that WDT cord-023726-2fduzqyb 511 4 occur occur VBP cord-023726-2fduzqyb 511 5 during during IN cord-023726-2fduzqyb 511 6 assembly assembly NN cord-023726-2fduzqyb 511 7 of of IN cord-023726-2fduzqyb 511 8 the the DT cord-023726-2fduzqyb 511 9 virus virus NN cord-023726-2fduzqyb 511 10 potentiate potentiate VBP cord-023726-2fduzqyb 511 11 penetration penetration NN cord-023726-2fduzqyb 511 12 of of IN cord-023726-2fduzqyb 511 13 a a DT cord-023726-2fduzqyb 511 14 susceptible susceptible JJ cord-023726-2fduzqyb 511 15 cell cell NN cord-023726-2fduzqyb 511 16 after after IN cord-023726-2fduzqyb 511 17 binding bind VBG cord-023726-2fduzqyb 511 18 of of IN cord-023726-2fduzqyb 511 19 the the DT cord-023726-2fduzqyb 511 20 virus virus NN cord-023726-2fduzqyb 511 21 to to IN cord-023726-2fduzqyb 511 22 it -PRON- PRP cord-023726-2fduzqyb 511 23 , , , cord-023726-2fduzqyb 511 24 and and CC cord-023726-2fduzqyb 511 25 the the DT cord-023726-2fduzqyb 511 26 subsequent subsequent JJ cord-023726-2fduzqyb 511 27 disassembly disassembly NN cord-023726-2fduzqyb 511 28 of of IN cord-023726-2fduzqyb 511 29 the the DT cord-023726-2fduzqyb 511 30 virion virion NN cord-023726-2fduzqyb 511 31 on on IN cord-023726-2fduzqyb 511 32 entry entry NN cord-023726-2fduzqyb 511 33 into into IN cord-023726-2fduzqyb 511 34 the the DT cord-023726-2fduzqyb 511 35 cell cell NN cord-023726-2fduzqyb 511 36 . . . cord-023726-2fduzqyb 512 1 A a DT cord-023726-2fduzqyb 512 2 few few JJ cord-023726-2fduzqyb 512 3 examples example NNS cord-023726-2fduzqyb 512 4 will will MD cord-023726-2fduzqyb 512 5 be be VB cord-023726-2fduzqyb 512 6 described describe VBN cord-023726-2fduzqyb 512 7 that that WDT cord-023726-2fduzqyb 512 8 illustrate illustrate VBP cord-023726-2fduzqyb 512 9 the the DT cord-023726-2fduzqyb 512 10 range range NN cord-023726-2fduzqyb 512 11 of of IN cord-023726-2fduzqyb 512 12 cleavage cleavage NN cord-023726-2fduzqyb 512 13 events event NNS cord-023726-2fduzqyb 512 14 that that WDT cord-023726-2fduzqyb 512 15 occur occur VBP cord-023726-2fduzqyb 512 16 in in IN cord-023726-2fduzqyb 512 17 different different JJ cord-023726-2fduzqyb 512 18 virus virus NN cord-023726-2fduzqyb 512 19 families family NNS cord-023726-2fduzqyb 512 20 . . . cord-023726-2fduzqyb 513 1 In in IN cord-023726-2fduzqyb 513 2 the the DT cord-023726-2fduzqyb 513 3 picornaviruses picornavirus NNS cord-023726-2fduzqyb 513 4 , , , cord-023726-2fduzqyb 513 5 a a DT cord-023726-2fduzqyb 513 6 provirion provirion NN cord-023726-2fduzqyb 513 7 is be VBZ cord-023726-2fduzqyb 513 8 first first RB cord-023726-2fduzqyb 513 9 formed form VBN cord-023726-2fduzqyb 513 10 that that WDT cord-023726-2fduzqyb 513 11 is be VBZ cord-023726-2fduzqyb 513 12 composed compose VBN cord-023726-2fduzqyb 513 13 of of IN cord-023726-2fduzqyb 513 14 the the DT cord-023726-2fduzqyb 513 15 viral viral JJ cord-023726-2fduzqyb 513 16 RNA RNA NNP cord-023726-2fduzqyb 513 17 complexed complexed JJ cord-023726-2fduzqyb 513 18 with with IN cord-023726-2fduzqyb 513 19 three three CD cord-023726-2fduzqyb 513 20 viral viral JJ cord-023726-2fduzqyb 513 21 proteins protein NNS cord-023726-2fduzqyb 513 22 , , , cord-023726-2fduzqyb 513 23 called call VBN cord-023726-2fduzqyb 513 24 VP0 VP0 NNP cord-023726-2fduzqyb 513 25 , , , cord-023726-2fduzqyb 513 26 VP1 VP1 NNP cord-023726-2fduzqyb 513 27 , , , cord-023726-2fduzqyb 513 28 and and CC cord-023726-2fduzqyb 513 29 VP3 VP3 NNP cord-023726-2fduzqyb 513 30 . . . cord-023726-2fduzqyb 514 1 During during IN cord-023726-2fduzqyb 514 2 maturation maturation NN cord-023726-2fduzqyb 514 3 to to TO cord-023726-2fduzqyb 514 4 form form VB cord-023726-2fduzqyb 514 5 the the DT cord-023726-2fduzqyb 514 6 virion virion NN cord-023726-2fduzqyb 514 7 , , , cord-023726-2fduzqyb 514 8 VP0 VP0 NNP cord-023726-2fduzqyb 514 9 is be VBZ cord-023726-2fduzqyb 514 10 cleaved cleave VBN cord-023726-2fduzqyb 514 11 to to IN cord-023726-2fduzqyb 514 12 VP2 VP2 NNP cord-023726-2fduzqyb 514 13 and and CC cord-023726-2fduzqyb 514 14 VP4 VP4 NNP cord-023726-2fduzqyb 514 15 . . . cord-023726-2fduzqyb 515 1 No no DT cord-023726-2fduzqyb 515 2 protease protease NN cord-023726-2fduzqyb 515 3 has have VBZ cord-023726-2fduzqyb 515 4 been be VBN cord-023726-2fduzqyb 515 5 found find VBN cord-023726-2fduzqyb 515 6 that that WDT cord-023726-2fduzqyb 515 7 performs perform VBZ cord-023726-2fduzqyb 515 8 this this DT cord-023726-2fduzqyb 515 9 cleavage cleavage NN cord-023726-2fduzqyb 515 10 , , , cord-023726-2fduzqyb 515 11 and and CC cord-023726-2fduzqyb 515 12 it -PRON- PRP cord-023726-2fduzqyb 515 13 has have VBZ cord-023726-2fduzqyb 515 14 been be VBN cord-023726-2fduzqyb 515 15 postulated postulate VBN cord-023726-2fduzqyb 515 16 that that IN cord-023726-2fduzqyb 515 17 the the DT cord-023726-2fduzqyb 515 18 virion virion NN cord-023726-2fduzqyb 515 19 RNA RNA NNP cord-023726-2fduzqyb 515 20 may may MD cord-023726-2fduzqyb 515 21 catalyze catalyze VB cord-023726-2fduzqyb 515 22 it -PRON- PRP cord-023726-2fduzqyb 515 23 . . . cord-023726-2fduzqyb 516 1 Cleavage cleavage NN cord-023726-2fduzqyb 516 2 to to TO cord-023726-2fduzqyb 516 3 produce produce VB cord-023726-2fduzqyb 516 4 VP4 VP4 NNP cord-023726-2fduzqyb 516 5 , , , cord-023726-2fduzqyb 516 6 which which WDT cord-023726-2fduzqyb 516 7 is be VBZ cord-023726-2fduzqyb 516 8 found find VBN cord-023726-2fduzqyb 516 9 within within IN cord-023726-2fduzqyb 516 10 the the DT cord-023726-2fduzqyb 516 11 interior interior NN cord-023726-2fduzqyb 516 12 of of IN cord-023726-2fduzqyb 516 13 the the DT cord-023726-2fduzqyb 516 14 capsid capsid NN cord-023726-2fduzqyb 516 15 shell shell NN cord-023726-2fduzqyb 516 16 , , , cord-023726-2fduzqyb 516 17 as as IN cord-023726-2fduzqyb 516 18 illustrated illustrate VBN cord-023726-2fduzqyb 516 19 schematically schematically RB cord-023726-2fduzqyb 516 20 in in IN cord-023726-2fduzqyb 516 21 Fig Fig NNP cord-023726-2fduzqyb 516 22 . . . cord-023726-2fduzqyb 517 1 2.9 2.9 CD cord-023726-2fduzqyb 517 2 , , , cord-023726-2fduzqyb 517 3 is be VBZ cord-023726-2fduzqyb 517 4 required require VBN cord-023726-2fduzqyb 517 5 for for IN cord-023726-2fduzqyb 517 6 the the DT cord-023726-2fduzqyb 517 7 virus virus NN cord-023726-2fduzqyb 517 8 to to TO cord-023726-2fduzqyb 517 9 be be VB cord-023726-2fduzqyb 517 10 infectious infectious JJ cord-023726-2fduzqyb 517 11 . . . cord-023726-2fduzqyb 518 1 As as IN cord-023726-2fduzqyb 518 2 described describe VBN cord-023726-2fduzqyb 518 3 in in IN cord-023726-2fduzqyb 518 4 Chapter chapter NN cord-023726-2fduzqyb 518 5 1 1 CD cord-023726-2fduzqyb 518 6 , , , cord-023726-2fduzqyb 518 7 VP4 VP4 NNP cord-023726-2fduzqyb 518 8 appears appear VBZ cord-023726-2fduzqyb 518 9 to to TO cord-023726-2fduzqyb 518 10 be be VB cord-023726-2fduzqyb 518 11 required require VBN cord-023726-2fduzqyb 518 12 for for IN cord-023726-2fduzqyb 518 13 entry entry NN cord-023726-2fduzqyb 518 14 of of IN cord-023726-2fduzqyb 518 15 the the DT cord-023726-2fduzqyb 518 16 virus virus NN cord-023726-2fduzqyb 518 17 into into IN cord-023726-2fduzqyb 518 18 the the DT cord-023726-2fduzqyb 518 19 cell cell NN cord-023726-2fduzqyb 518 20 . . . cord-023726-2fduzqyb 519 1 This this DT cord-023726-2fduzqyb 519 2 maturation maturation NN cord-023726-2fduzqyb 519 3 cleavage cleavage NN cord-023726-2fduzqyb 519 4 has have VBZ cord-023726-2fduzqyb 519 5 another another DT cord-023726-2fduzqyb 519 6 important important JJ cord-023726-2fduzqyb 519 7 consequence consequence NN cord-023726-2fduzqyb 519 8 . . . cord-023726-2fduzqyb 520 1 Whereas whereas IN cord-023726-2fduzqyb 520 2 the the DT cord-023726-2fduzqyb 520 3 provirion provirion NN cord-023726-2fduzqyb 520 4 is be VBZ cord-023726-2fduzqyb 520 5 quite quite RB cord-023726-2fduzqyb 520 6 unstable unstable JJ cord-023726-2fduzqyb 520 7 , , , cord-023726-2fduzqyb 520 8 the the DT cord-023726-2fduzqyb 520 9 mature mature JJ cord-023726-2fduzqyb 520 10 virion virion NN cord-023726-2fduzqyb 520 11 is be VBZ cord-023726-2fduzqyb 520 12 very very RB cord-023726-2fduzqyb 520 13 stable stable JJ cord-023726-2fduzqyb 520 14 . . . cord-023726-2fduzqyb 521 1 The the DT cord-023726-2fduzqyb 521 2 poliovirus poliovirus NN cord-023726-2fduzqyb 521 3 virion virion NN cord-023726-2fduzqyb 521 4 will will MD cord-023726-2fduzqyb 521 5 survive survive VB cord-023726-2fduzqyb 521 6 treatment treatment NN cord-023726-2fduzqyb 521 7 with with IN cord-023726-2fduzqyb 521 8 proteolytic proteolytic JJ cord-023726-2fduzqyb 521 9 enzymes enzyme NNS cord-023726-2fduzqyb 521 10 and and CC cord-023726-2fduzqyb 521 11 detergents detergent NNS cord-023726-2fduzqyb 521 12 , , , cord-023726-2fduzqyb 521 13 and and CC cord-023726-2fduzqyb 521 14 survives survive VBZ cord-023726-2fduzqyb 521 15 exposure exposure NN cord-023726-2fduzqyb 521 16 to to IN cord-023726-2fduzqyb 521 17 the the DT cord-023726-2fduzqyb 521 18 acidic acidic JJ cord-023726-2fduzqyb 521 19 pH ph NN cord-023726-2fduzqyb 521 20 of of IN cord-023726-2fduzqyb 521 21 less less JJR cord-023726-2fduzqyb 521 22 than than IN cord-023726-2fduzqyb 521 23 2 2 CD cord-023726-2fduzqyb 521 24 that that WDT cord-023726-2fduzqyb 521 25 is be VBZ cord-023726-2fduzqyb 521 26 present present JJ cord-023726-2fduzqyb 521 27 in in IN cord-023726-2fduzqyb 521 28 the the DT cord-023726-2fduzqyb 521 29 stomach stomach NN cord-023726-2fduzqyb 521 30 . . . cord-023726-2fduzqyb 522 1 Only only RB cord-023726-2fduzqyb 522 2 on on IN cord-023726-2fduzqyb 522 3 binding bind VBG cord-023726-2fduzqyb 522 4 to to IN cord-023726-2fduzqyb 522 5 its -PRON- PRP$ cord-023726-2fduzqyb 522 6 receptor receptor NN cord-023726-2fduzqyb 522 7 ( ( -LRB- cord-023726-2fduzqyb 522 8 Figs fig NNS cord-023726-2fduzqyb 522 9 . . . cord-023726-2fduzqyb 523 1 1.5 1.5 CD cord-023726-2fduzqyb 523 2 and and CC cord-023726-2fduzqyb 523 3 2.9 2.9 CD cord-023726-2fduzqyb 523 4 ) ) -RRB- cord-023726-2fduzqyb 523 5 is be VBZ cord-023726-2fduzqyb 523 6 poliovirus poliovirus NN cord-023726-2fduzqyb 523 7 destabilized destabilize VBN cord-023726-2fduzqyb 523 8 such such JJ cord-023726-2fduzqyb 523 9 that that IN cord-023726-2fduzqyb 523 10 VP4 VP4 NNP cord-023726-2fduzqyb 523 11 can can MD cord-023726-2fduzqyb 523 12 be be VB cord-023726-2fduzqyb 523 13 released release VBN cord-023726-2fduzqyb 523 14 for for IN cord-023726-2fduzqyb 523 15 entry entry NN cord-023726-2fduzqyb 523 16 of of IN cord-023726-2fduzqyb 523 17 the the DT cord-023726-2fduzqyb 523 18 viral viral JJ cord-023726-2fduzqyb 523 19 RNA RNA NNP cord-023726-2fduzqyb 523 20 into into IN cord-023726-2fduzqyb 523 21 the the DT cord-023726-2fduzqyb 523 22 host host NN cord-023726-2fduzqyb 523 23 cell cell NN cord-023726-2fduzqyb 523 24 . . . cord-023726-2fduzqyb 524 1 Similarly similarly RB cord-023726-2fduzqyb 524 2 , , , cord-023726-2fduzqyb 524 3 the the DT cord-023726-2fduzqyb 524 4 insect insect NN cord-023726-2fduzqyb 524 5 nodaviruses nodaviruse VBZ cord-023726-2fduzqyb 524 6 first first RB cord-023726-2fduzqyb 524 7 assemble assemble VB cord-023726-2fduzqyb 524 8 as as IN cord-023726-2fduzqyb 524 9 a a DT cord-023726-2fduzqyb 524 10 procapsid procapsid NN cord-023726-2fduzqyb 524 11 containing contain VBG cord-023726-2fduzqyb 524 12 the the DT cord-023726-2fduzqyb 524 13 RNA RNA NNP cord-023726-2fduzqyb 524 14 and and CC cord-023726-2fduzqyb 524 15 180 180 CD cord-023726-2fduzqyb 524 16 copies copy NNS cord-023726-2fduzqyb 524 17 of of IN cord-023726-2fduzqyb 524 18 a a DT cord-023726-2fduzqyb 524 19 single single JJ cord-023726-2fduzqyb 524 20 protein protein NN cord-023726-2fduzqyb 524 21 species species NN cord-023726-2fduzqyb 524 22 called call VBN cord-023726-2fduzqyb 524 23 α α NNP cord-023726-2fduzqyb 524 24 ( ( -LRB- cord-023726-2fduzqyb 524 25 44 44 CD cord-023726-2fduzqyb 524 26 kDa kDa NNS cord-023726-2fduzqyb 524 27 ) ) -RRB- cord-023726-2fduzqyb 524 28 . . . cord-023726-2fduzqyb 525 1 Over over IN cord-023726-2fduzqyb 525 2 a a DT cord-023726-2fduzqyb 525 3 period period NN cord-023726-2fduzqyb 525 4 of of IN cord-023726-2fduzqyb 525 5 many many JJ cord-023726-2fduzqyb 525 6 hours hour NNS cord-023726-2fduzqyb 525 7 , , , cord-023726-2fduzqyb 525 8 spontaneous spontaneous JJ cord-023726-2fduzqyb 525 9 cleavage cleavage NN cord-023726-2fduzqyb 525 10 of of IN cord-023726-2fduzqyb 525 11 α α NN cord-023726-2fduzqyb 525 12 occurs occur VBZ cord-023726-2fduzqyb 525 13 to to TO cord-023726-2fduzqyb 525 14 form form VB cord-023726-2fduzqyb 525 15 β β NNP cord-023726-2fduzqyb 525 16 ( ( -LRB- cord-023726-2fduzqyb 525 17 40 40 CD cord-023726-2fduzqyb 525 18 kDa kDa NNPS cord-023726-2fduzqyb 525 19 ) ) -RRB- cord-023726-2fduzqyb 525 20 and and CC cord-023726-2fduzqyb 525 21 γ γ NNP cord-023726-2fduzqyb 525 22 ( ( -LRB- cord-023726-2fduzqyb 525 23 4 4 CD cord-023726-2fduzqyb 525 24 kDa kDa NNP cord-023726-2fduzqyb 525 25 ) ) -RRB- cord-023726-2fduzqyb 525 26 . . . cord-023726-2fduzqyb 526 1 This this DT cord-023726-2fduzqyb 526 2 cleavage cleavage NN cord-023726-2fduzqyb 526 3 is be VBZ cord-023726-2fduzqyb 526 4 required require VBN cord-023726-2fduzqyb 526 5 for for IN cord-023726-2fduzqyb 526 6 the the DT cord-023726-2fduzqyb 526 7 particle particle NN cord-023726-2fduzqyb 526 8 to to TO cord-023726-2fduzqyb 526 9 be be VB cord-023726-2fduzqyb 526 10 infectious infectious JJ cord-023726-2fduzqyb 526 11 . . . cord-023726-2fduzqyb 527 1 These these DT cord-023726-2fduzqyb 527 2 events event NNS cord-023726-2fduzqyb 527 3 in in IN cord-023726-2fduzqyb 527 4 nodaviruses nodaviruses NNP cord-023726-2fduzqyb 527 5 have have VBP cord-023726-2fduzqyb 527 6 been be VBN cord-023726-2fduzqyb 527 7 well well RB cord-023726-2fduzqyb 527 8 studied study VBN cord-023726-2fduzqyb 527 9 because because IN cord-023726-2fduzqyb 527 10 it -PRON- PRP cord-023726-2fduzqyb 527 11 has have VBZ cord-023726-2fduzqyb 527 12 been be VBN cord-023726-2fduzqyb 527 13 possible possible JJ cord-023726-2fduzqyb 527 14 to to TO cord-023726-2fduzqyb 527 15 assemble assemble VB cord-023726-2fduzqyb 527 16 particles particle NNS cord-023726-2fduzqyb 527 17 in in IN cord-023726-2fduzqyb 527 18 vitro vitro FW cord-023726-2fduzqyb 527 19 , , , cord-023726-2fduzqyb 527 20 and and CC cord-023726-2fduzqyb 527 21 the the DT cord-023726-2fduzqyb 527 22 structures structure NNS cord-023726-2fduzqyb 527 23 of of IN cord-023726-2fduzqyb 527 24 both both CC cord-023726-2fduzqyb 527 25 cleaved cleaved JJ cord-023726-2fduzqyb 527 26 and and CC cord-023726-2fduzqyb 527 27 uncleaved uncleaved JJ cord-023726-2fduzqyb 527 28 particles particle NNS cord-023726-2fduzqyb 527 29 have have VBP cord-023726-2fduzqyb 527 30 been be VBN cord-023726-2fduzqyb 527 31 solved solve VBN cord-023726-2fduzqyb 527 32 to to IN cord-023726-2fduzqyb 527 33 atomic atomic JJ cord-023726-2fduzqyb 527 34 resolution resolution NN cord-023726-2fduzqyb 527 35 . . . cord-023726-2fduzqyb 528 1 Rotaviruses Rotaviruses NNP cord-023726-2fduzqyb 528 2 , , , cord-023726-2fduzqyb 528 3 which which WDT cord-023726-2fduzqyb 528 4 form form VBP cord-023726-2fduzqyb 528 5 a a DT cord-023726-2fduzqyb 528 6 genus genus NN cord-023726-2fduzqyb 528 7 in in IN cord-023726-2fduzqyb 528 8 the the DT cord-023726-2fduzqyb 528 9 family family NN cord-023726-2fduzqyb 528 10 Reoviridae Reoviridae NNP cord-023726-2fduzqyb 528 11 , , , cord-023726-2fduzqyb 528 12 must must MD cord-023726-2fduzqyb 528 13 be be VB cord-023726-2fduzqyb 528 14 activated activate VBN cord-023726-2fduzqyb 528 15 by by IN cord-023726-2fduzqyb 528 16 cleavage cleavage NN cord-023726-2fduzqyb 528 17 with with IN cord-023726-2fduzqyb 528 18 trypsin trypsin NN cord-023726-2fduzqyb 528 19 after after IN cord-023726-2fduzqyb 528 20 release release NN cord-023726-2fduzqyb 528 21 from from IN cord-023726-2fduzqyb 528 22 an an DT cord-023726-2fduzqyb 528 23 infected infected JJ cord-023726-2fduzqyb 528 24 cell cell NN cord-023726-2fduzqyb 528 25 in in IN cord-023726-2fduzqyb 528 26 order order NN cord-023726-2fduzqyb 528 27 to to TO cord-023726-2fduzqyb 528 28 be be VB cord-023726-2fduzqyb 528 29 infectious infectious JJ cord-023726-2fduzqyb 528 30 . . . cord-023726-2fduzqyb 529 1 Trypsin Trypsin NNP cord-023726-2fduzqyb 529 2 is be VBZ cord-023726-2fduzqyb 529 3 present present JJ cord-023726-2fduzqyb 529 4 in in IN cord-023726-2fduzqyb 529 5 the the DT cord-023726-2fduzqyb 529 6 gut gut NN cord-023726-2fduzqyb 529 7 , , , cord-023726-2fduzqyb 529 8 where where WRB cord-023726-2fduzqyb 529 9 the the DT cord-023726-2fduzqyb 529 10 viruses virus NNS cord-023726-2fduzqyb 529 11 replicate replicate VBP cord-023726-2fduzqyb 529 12 , , , cord-023726-2fduzqyb 529 13 and and CC cord-023726-2fduzqyb 529 14 activation activation NN cord-023726-2fduzqyb 529 15 occurs occur VBZ cord-023726-2fduzqyb 529 16 normally normally RB cord-023726-2fduzqyb 529 17 during during IN cord-023726-2fduzqyb 529 18 the the DT cord-023726-2fduzqyb 529 19 infection infection NN cord-023726-2fduzqyb 529 20 cycle cycle NN cord-023726-2fduzqyb 529 21 of of IN cord-023726-2fduzqyb 529 22 the the DT cord-023726-2fduzqyb 529 23 virus virus NN cord-023726-2fduzqyb 529 24 in in IN cord-023726-2fduzqyb 529 25 animals animal NNS cord-023726-2fduzqyb 529 26 . . . cord-023726-2fduzqyb 530 1 When when WRB cord-023726-2fduzqyb 530 2 the the DT cord-023726-2fduzqyb 530 3 viruses virus NNS cord-023726-2fduzqyb 530 4 are be VBP cord-023726-2fduzqyb 530 5 grown grow VBN cord-023726-2fduzqyb 530 6 in in IN cord-023726-2fduzqyb 530 7 cultured cultured JJ cord-023726-2fduzqyb 530 8 cells cell NNS cord-023726-2fduzqyb 530 9 , , , cord-023726-2fduzqyb 530 10 however however RB cord-023726-2fduzqyb 530 11 , , , cord-023726-2fduzqyb 530 12 trypsin trypsin NN cord-023726-2fduzqyb 530 13 must must MD cord-023726-2fduzqyb 530 14 be be VB cord-023726-2fduzqyb 530 15 supplied supply VBN cord-023726-2fduzqyb 530 16 exogenously exogenously RB cord-023726-2fduzqyb 530 17 . . . cord-023726-2fduzqyb 531 1 A a DT cord-023726-2fduzqyb 531 2 different different JJ cord-023726-2fduzqyb 531 3 type type NN cord-023726-2fduzqyb 531 4 of of IN cord-023726-2fduzqyb 531 5 cleavage cleavage NN cord-023726-2fduzqyb 531 6 event event NN cord-023726-2fduzqyb 531 7 occurs occur VBZ cord-023726-2fduzqyb 531 8 during during IN cord-023726-2fduzqyb 531 9 assembly assembly NN cord-023726-2fduzqyb 531 10 of of IN cord-023726-2fduzqyb 531 11 retroviruses retrovirus NNS cord-023726-2fduzqyb 531 12 and and CC cord-023726-2fduzqyb 531 13 adenoviruses adenovirus NNS cord-023726-2fduzqyb 531 14 , , , cord-023726-2fduzqyb 531 15 as as RB cord-023726-2fduzqyb 531 16 well well RB cord-023726-2fduzqyb 531 17 as as IN cord-023726-2fduzqyb 531 18 of of IN cord-023726-2fduzqyb 531 19 a a DT cord-023726-2fduzqyb 531 20 number number NN cord-023726-2fduzqyb 531 21 of of IN cord-023726-2fduzqyb 531 22 other other JJ cord-023726-2fduzqyb 531 23 viruses virus NNS cord-023726-2fduzqyb 531 24 . . . cord-023726-2fduzqyb 532 1 During during IN cord-023726-2fduzqyb 532 2 assembly assembly NN cord-023726-2fduzqyb 532 3 of of IN cord-023726-2fduzqyb 532 4 retroviruses retrovirus NNS cord-023726-2fduzqyb 532 5 , , , cord-023726-2fduzqyb 532 6 the the DT cord-023726-2fduzqyb 532 7 Gag Gag NNP cord-023726-2fduzqyb 532 8 and and CC cord-023726-2fduzqyb 532 9 Gag Gag NNP cord-023726-2fduzqyb 532 10 - - HYPH cord-023726-2fduzqyb 532 11 Pol pol NN cord-023726-2fduzqyb 532 12 precursor precursor NN cord-023726-2fduzqyb 532 13 polyproteins polyprotein NNS cord-023726-2fduzqyb 532 14 are be VBP cord-023726-2fduzqyb 532 15 incorporated incorporate VBN cord-023726-2fduzqyb 532 16 , , , cord-023726-2fduzqyb 532 17 together together RB cord-023726-2fduzqyb 532 18 with with IN cord-023726-2fduzqyb 532 19 the the DT cord-023726-2fduzqyb 532 20 viral viral JJ cord-023726-2fduzqyb 532 21 RNA RNA NNP cord-023726-2fduzqyb 532 22 , , , cord-023726-2fduzqyb 532 23 into into IN cord-023726-2fduzqyb 532 24 a a DT cord-023726-2fduzqyb 532 25 precursor precursor NN cord-023726-2fduzqyb 532 26 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 532 27 . . . cord-023726-2fduzqyb 533 1 These these DT cord-023726-2fduzqyb 533 2 polyproteins polyprotein NNS cord-023726-2fduzqyb 533 3 must must MD cord-023726-2fduzqyb 533 4 be be VB cord-023726-2fduzqyb 533 5 cleaved cleave VBN cord-023726-2fduzqyb 533 6 into into IN cord-023726-2fduzqyb 533 7 several several JJ cord-023726-2fduzqyb 533 8 pieces piece NNS cord-023726-2fduzqyb 533 9 by by IN cord-023726-2fduzqyb 533 10 a a DT cord-023726-2fduzqyb 533 11 protease protease NN cord-023726-2fduzqyb 533 12 present present JJ cord-023726-2fduzqyb 533 13 in in IN cord-023726-2fduzqyb 533 14 the the DT cord-023726-2fduzqyb 533 15 polyprotein polyprotein NN cord-023726-2fduzqyb 533 16 if if IN cord-023726-2fduzqyb 533 17 the the DT cord-023726-2fduzqyb 533 18 virus virus NN cord-023726-2fduzqyb 533 19 is be VBZ cord-023726-2fduzqyb 533 20 to to TO cord-023726-2fduzqyb 533 21 be be VB cord-023726-2fduzqyb 533 22 infectious infectious JJ cord-023726-2fduzqyb 533 23 . . . cord-023726-2fduzqyb 534 1 These these DT cord-023726-2fduzqyb 534 2 cleavages cleavage NNS cord-023726-2fduzqyb 534 3 often often RB cord-023726-2fduzqyb 534 4 visibly visibly RB cord-023726-2fduzqyb 534 5 alter alter VBP cord-023726-2fduzqyb 534 6 the the DT cord-023726-2fduzqyb 534 7 structure structure NN cord-023726-2fduzqyb 534 8 of of IN cord-023726-2fduzqyb 534 9 the the DT cord-023726-2fduzqyb 534 10 particle particle NN cord-023726-2fduzqyb 534 11 as as IN cord-023726-2fduzqyb 534 12 seen see VBN cord-023726-2fduzqyb 534 13 in in IN cord-023726-2fduzqyb 534 14 the the DT cord-023726-2fduzqyb 534 15 electron electron NN cord-023726-2fduzqyb 534 16 microscope microscope NN cord-023726-2fduzqyb 534 17 ( ( -LRB- cord-023726-2fduzqyb 534 18 Fig Fig NNP cord-023726-2fduzqyb 534 19 . . . cord-023726-2fduzqyb 534 20 2.21 2.21 CD cord-023726-2fduzqyb 534 21 ) ) -RRB- cord-023726-2fduzqyb 534 22 . . . cord-023726-2fduzqyb 535 1 An an DT cord-023726-2fduzqyb 535 2 analogous analogous JJ cord-023726-2fduzqyb 535 3 situation situation NN cord-023726-2fduzqyb 535 4 occurs occur VBZ cord-023726-2fduzqyb 535 5 in in IN cord-023726-2fduzqyb 535 6 adenoviruses adenovirus NNS cord-023726-2fduzqyb 535 7 , , , cord-023726-2fduzqyb 535 8 where where WRB cord-023726-2fduzqyb 535 9 a a DT cord-023726-2fduzqyb 535 10 viral viral JJ cord-023726-2fduzqyb 535 11 protease protease NN cord-023726-2fduzqyb 535 12 processes process VBZ cord-023726-2fduzqyb 535 13 a a DT cord-023726-2fduzqyb 535 14 protein protein NN cord-023726-2fduzqyb 535 15 precursor precursor NN cord-023726-2fduzqyb 535 16 in in IN cord-023726-2fduzqyb 535 17 the the DT cord-023726-2fduzqyb 535 18 core core NN cord-023726-2fduzqyb 535 19 of of IN cord-023726-2fduzqyb 535 20 the the DT cord-023726-2fduzqyb 535 21 immature immature JJ cord-023726-2fduzqyb 535 22 virion virion NN cord-023726-2fduzqyb 535 23 . . . cord-023726-2fduzqyb 536 1 In in IN cord-023726-2fduzqyb 536 2 most most JJS cord-023726-2fduzqyb 536 3 enveloped envelop VBN cord-023726-2fduzqyb 536 4 viruses virus NNS cord-023726-2fduzqyb 536 5 , , , cord-023726-2fduzqyb 536 6 one one CD cord-023726-2fduzqyb 536 7 of of IN cord-023726-2fduzqyb 536 8 the the DT cord-023726-2fduzqyb 536 9 envelope envelope NN cord-023726-2fduzqyb 536 10 proteins protein NNS cord-023726-2fduzqyb 536 11 is be VBZ cord-023726-2fduzqyb 536 12 produced produce VBN cord-023726-2fduzqyb 536 13 as as IN cord-023726-2fduzqyb 536 14 a a DT cord-023726-2fduzqyb 536 15 precursor precursor NN cord-023726-2fduzqyb 536 16 whose whose WP$ cord-023726-2fduzqyb 536 17 cleavage cleavage NN cord-023726-2fduzqyb 536 18 is be VBZ cord-023726-2fduzqyb 536 19 required require VBN cord-023726-2fduzqyb 536 20 to to TO cord-023726-2fduzqyb 536 21 activate activate VB cord-023726-2fduzqyb 536 22 the the DT cord-023726-2fduzqyb 536 23 infectivity infectivity NN cord-023726-2fduzqyb 536 24 of of IN cord-023726-2fduzqyb 536 25 the the DT cord-023726-2fduzqyb 536 26 virus virus NN cord-023726-2fduzqyb 536 27 . . . cord-023726-2fduzqyb 537 1 This this DT cord-023726-2fduzqyb 537 2 cleavage cleavage NN cord-023726-2fduzqyb 537 3 may may MD cord-023726-2fduzqyb 537 4 occur occur VB cord-023726-2fduzqyb 537 5 prior prior RB cord-023726-2fduzqyb 537 6 to to IN cord-023726-2fduzqyb 537 7 budding bud VBG cord-023726-2fduzqyb 537 8 , , , cord-023726-2fduzqyb 537 9 catalyzed catalyze VBN cord-023726-2fduzqyb 537 10 by by IN cord-023726-2fduzqyb 537 11 a a DT cord-023726-2fduzqyb 537 12 host host NN cord-023726-2fduzqyb 537 13 enzyme enzyme NN cord-023726-2fduzqyb 537 14 called call VBN cord-023726-2fduzqyb 537 15 furin furin NN cord-023726-2fduzqyb 537 16 , , , cord-023726-2fduzqyb 537 17 or or CC cord-023726-2fduzqyb 537 18 may may MD cord-023726-2fduzqyb 537 19 occur occur VB cord-023726-2fduzqyb 537 20 after after IN cord-023726-2fduzqyb 537 21 release release NN cord-023726-2fduzqyb 537 22 of of IN cord-023726-2fduzqyb 537 23 the the DT cord-023726-2fduzqyb 537 24 virus virus NN cord-023726-2fduzqyb 537 25 , , , cord-023726-2fduzqyb 537 26 catalyzed catalyze VBN cord-023726-2fduzqyb 537 27 by by IN cord-023726-2fduzqyb 537 28 other other JJ cord-023726-2fduzqyb 537 29 host host NN cord-023726-2fduzqyb 537 30 enzymes enzyme NNS cord-023726-2fduzqyb 537 31 . . . cord-023726-2fduzqyb 538 1 The the DT cord-023726-2fduzqyb 538 2 example example NN cord-023726-2fduzqyb 538 3 of of IN cord-023726-2fduzqyb 538 4 the the DT cord-023726-2fduzqyb 538 5 hemagglutinin hemagglutinin NN cord-023726-2fduzqyb 538 6 of of IN cord-023726-2fduzqyb 538 7 influenza influenza NN cord-023726-2fduzqyb 538 8 virus virus NN cord-023726-2fduzqyb 538 9 was be VBD cord-023726-2fduzqyb 538 10 described describe VBN cord-023726-2fduzqyb 538 11 in in IN cord-023726-2fduzqyb 538 12 Chapter chapter NN cord-023726-2fduzqyb 538 13 1 1 CD cord-023726-2fduzqyb 538 14 . . . cord-023726-2fduzqyb 539 1 This this DT cord-023726-2fduzqyb 539 2 protein protein NN cord-023726-2fduzqyb 539 3 is be VBZ cord-023726-2fduzqyb 539 4 produced produce VBN cord-023726-2fduzqyb 539 5 as as IN cord-023726-2fduzqyb 539 6 a a DT cord-023726-2fduzqyb 539 7 precursor precursor NN cord-023726-2fduzqyb 539 8 called call VBN cord-023726-2fduzqyb 539 9 HA0 HA0 NNP cord-023726-2fduzqyb 539 10 , , , cord-023726-2fduzqyb 539 11 which which WDT cord-023726-2fduzqyb 539 12 is be VBZ cord-023726-2fduzqyb 539 13 cleaved cleave VBN cord-023726-2fduzqyb 539 14 to to IN cord-023726-2fduzqyb 539 15 HA1 HA1 NNP cord-023726-2fduzqyb 539 16 and and CC cord-023726-2fduzqyb 539 17 HA2 HA2 NNP cord-023726-2fduzqyb 539 18 ( ( -LRB- cord-023726-2fduzqyb 539 19 Fig Fig NNP cord-023726-2fduzqyb 539 20 . . . cord-023726-2fduzqyb 539 21 1.6 1.6 CD cord-023726-2fduzqyb 539 22 ) ) -RRB- cord-023726-2fduzqyb 539 23 . . . cord-023726-2fduzqyb 540 1 Cleavage cleavage NN cord-023726-2fduzqyb 540 2 is be VBZ cord-023726-2fduzqyb 540 3 required require VBN cord-023726-2fduzqyb 540 4 to to TO cord-023726-2fduzqyb 540 5 potentiate potentiate VB cord-023726-2fduzqyb 540 6 the the DT cord-023726-2fduzqyb 540 7 fusion fusion NN cord-023726-2fduzqyb 540 8 activity activity NN cord-023726-2fduzqyb 540 9 present present JJ cord-023726-2fduzqyb 540 10 at at IN cord-023726-2fduzqyb 540 11 the the DT cord-023726-2fduzqyb 540 12 N n CD cord-023726-2fduzqyb 540 13 terminus terminus NN cord-023726-2fduzqyb 540 14 of of IN cord-023726-2fduzqyb 540 15 HA2 HA2 NNP cord-023726-2fduzqyb 540 16 . . . cord-023726-2fduzqyb 541 1 As as IN cord-023726-2fduzqyb 541 2 a a DT cord-023726-2fduzqyb 541 3 second second JJ cord-023726-2fduzqyb 541 4 example example NN cord-023726-2fduzqyb 541 5 , , , cord-023726-2fduzqyb 541 6 alphaviruses alphavirus NNS cord-023726-2fduzqyb 541 7 produce produce VBP cord-023726-2fduzqyb 541 8 two two CD cord-023726-2fduzqyb 541 9 envelope envelope NN cord-023726-2fduzqyb 541 10 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 541 11 that that WDT cord-023726-2fduzqyb 541 12 form form VBP cord-023726-2fduzqyb 541 13 a a DT cord-023726-2fduzqyb 541 14 heterodimer heterodimer NN cord-023726-2fduzqyb 541 15 and and CC cord-023726-2fduzqyb 541 16 one one CD cord-023726-2fduzqyb 541 17 of of IN cord-023726-2fduzqyb 541 18 the the DT cord-023726-2fduzqyb 541 19 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 541 20 is be VBZ cord-023726-2fduzqyb 541 21 produced produce VBN cord-023726-2fduzqyb 541 22 as as IN cord-023726-2fduzqyb 541 23 a a DT cord-023726-2fduzqyb 541 24 precursor precursor NN cord-023726-2fduzqyb 541 25 , , , cord-023726-2fduzqyb 541 26 as as IN cord-023726-2fduzqyb 541 27 described describe VBN cord-023726-2fduzqyb 541 28 before before RB cord-023726-2fduzqyb 541 29 . . . cord-023726-2fduzqyb 542 1 The the DT cord-023726-2fduzqyb 542 2 heterodimer heterodimer NN cord-023726-2fduzqyb 542 3 containing contain VBG cord-023726-2fduzqyb 542 4 the the DT cord-023726-2fduzqyb 542 5 uncleaved uncleaved JJ cord-023726-2fduzqyb 542 6 precursor precursor NN cord-023726-2fduzqyb 542 7 is be VBZ cord-023726-2fduzqyb 542 8 quite quite RB cord-023726-2fduzqyb 542 9 stable stable JJ cord-023726-2fduzqyb 542 10 , , , cord-023726-2fduzqyb 542 11 so so IN cord-023726-2fduzqyb 542 12 that that IN cord-023726-2fduzqyb 542 13 a a DT cord-023726-2fduzqyb 542 14 particle particle NN cord-023726-2fduzqyb 542 15 containing contain VBG cord-023726-2fduzqyb 542 16 uncleaved uncleaved JJ cord-023726-2fduzqyb 542 17 heterodimer heterodimer NN cord-023726-2fduzqyb 542 18 is be VBZ cord-023726-2fduzqyb 542 19 not not RB cord-023726-2fduzqyb 542 20 infectious infectious JJ cord-023726-2fduzqyb 542 21 . . . cord-023726-2fduzqyb 543 1 The the DT cord-023726-2fduzqyb 543 2 cleaved cleaved JJ cord-023726-2fduzqyb 543 3 heterodimer heterodimer NN cord-023726-2fduzqyb 543 4 , , , cord-023726-2fduzqyb 543 5 which which WDT cord-023726-2fduzqyb 543 6 is be VBZ cord-023726-2fduzqyb 543 7 required require VBN cord-023726-2fduzqyb 543 8 for for IN cord-023726-2fduzqyb 543 9 virus virus NN cord-023726-2fduzqyb 543 10 entry entry NN cord-023726-2fduzqyb 543 11 , , , cord-023726-2fduzqyb 543 12 is be VBZ cord-023726-2fduzqyb 543 13 much much RB cord-023726-2fduzqyb 543 14 less less RBR cord-023726-2fduzqyb 543 15 stable stable JJ cord-023726-2fduzqyb 543 16 and and CC cord-023726-2fduzqyb 543 17 dissociates dissociate VBZ cord-023726-2fduzqyb 543 18 readily readily RB cord-023726-2fduzqyb 543 19 during during IN cord-023726-2fduzqyb 543 20 infection infection NN cord-023726-2fduzqyb 543 21 . . . cord-023726-2fduzqyb 544 1 Thus thus RB cord-023726-2fduzqyb 544 2 , , , cord-023726-2fduzqyb 544 3 in in IN cord-023726-2fduzqyb 544 4 contrast contrast NN cord-023726-2fduzqyb 544 5 to to IN cord-023726-2fduzqyb 544 6 the the DT cord-023726-2fduzqyb 544 7 poliovirus poliovirus NN cord-023726-2fduzqyb 544 8 maturation maturation NN cord-023726-2fduzqyb 544 9 cleavage cleavage NN cord-023726-2fduzqyb 544 10 , , , cord-023726-2fduzqyb 544 11 the the DT cord-023726-2fduzqyb 544 12 alphavirus alphavirus NNP cord-023726-2fduzqyb 544 13 cleavage cleavage NN cord-023726-2fduzqyb 544 14 makes make VBZ cord-023726-2fduzqyb 544 15 the the DT cord-023726-2fduzqyb 544 16 virion virion NN cord-023726-2fduzqyb 544 17 less less RBR cord-023726-2fduzqyb 544 18 stable stable JJ cord-023726-2fduzqyb 544 19 rather rather RB cord-023726-2fduzqyb 544 20 than than IN cord-023726-2fduzqyb 544 21 more more RBR cord-023726-2fduzqyb 544 22 stable stable JJ cord-023726-2fduzqyb 544 23 . . . cord-023726-2fduzqyb 545 1 Maturation maturation NN cord-023726-2fduzqyb 545 2 cleavages cleavage NNS cord-023726-2fduzqyb 545 3 also also RB cord-023726-2fduzqyb 545 4 occur occur VBP cord-023726-2fduzqyb 545 5 in in IN cord-023726-2fduzqyb 545 6 the the DT cord-023726-2fduzqyb 545 7 envelope envelope NN cord-023726-2fduzqyb 545 8 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 545 9 of of IN cord-023726-2fduzqyb 545 10 retroviruses retrovirus NNS cord-023726-2fduzqyb 545 11 , , , cord-023726-2fduzqyb 545 12 paramyxoviruses paramyxovirus NNS cord-023726-2fduzqyb 545 13 , , , cord-023726-2fduzqyb 545 14 flaviviruses flavivirus NNS cord-023726-2fduzqyb 545 15 , , , cord-023726-2fduzqyb 545 16 and and CC cord-023726-2fduzqyb 545 17 coronaviruses coronaviruse NNS cord-023726-2fduzqyb 545 18 . . . cord-023726-2fduzqyb 546 1 DNA DNA NNP cord-023726-2fduzqyb 546 2 or or CC cord-023726-2fduzqyb 546 3 RNA RNA NNP cord-023726-2fduzqyb 546 4 has have VBZ cord-023726-2fduzqyb 546 5 a a DT cord-023726-2fduzqyb 546 6 high high JJ cord-023726-2fduzqyb 546 7 net net JJ cord-023726-2fduzqyb 546 8 negative negative JJ cord-023726-2fduzqyb 546 9 charge charge NN cord-023726-2fduzqyb 546 10 , , , cord-023726-2fduzqyb 546 11 and and CC cord-023726-2fduzqyb 546 12 there there EX cord-023726-2fduzqyb 546 13 is be VBZ cord-023726-2fduzqyb 546 14 a a DT cord-023726-2fduzqyb 546 15 need need NN cord-023726-2fduzqyb 546 16 for for IN cord-023726-2fduzqyb 546 17 counterions counterion NNS cord-023726-2fduzqyb 546 18 to to TO cord-023726-2fduzqyb 546 19 neutralize neutralize VB cord-023726-2fduzqyb 546 20 this this DT cord-023726-2fduzqyb 546 21 charge charge NN cord-023726-2fduzqyb 546 22 in in IN cord-023726-2fduzqyb 546 23 order order NN cord-023726-2fduzqyb 546 24 to to TO cord-023726-2fduzqyb 546 25 form form VB cord-023726-2fduzqyb 546 26 a a DT cord-023726-2fduzqyb 546 27 virion virion NN cord-023726-2fduzqyb 546 28 . . . cord-023726-2fduzqyb 547 1 In in IN cord-023726-2fduzqyb 547 2 many many JJ cord-023726-2fduzqyb 547 3 viruses virus NNS cord-023726-2fduzqyb 547 4 , , , cord-023726-2fduzqyb 547 5 positively positively RB cord-023726-2fduzqyb 547 6 charged charge VBN cord-023726-2fduzqyb 547 7 polymers polymer NNS cord-023726-2fduzqyb 547 8 are be VBP cord-023726-2fduzqyb 547 9 incorporated incorporate VBN cord-023726-2fduzqyb 547 10 that that WDT cord-023726-2fduzqyb 547 11 neutralize neutralize VBP cord-023726-2fduzqyb 547 12 half half NN cord-023726-2fduzqyb 547 13 or or CC cord-023726-2fduzqyb 547 14 so so RB cord-023726-2fduzqyb 547 15 of of IN cord-023726-2fduzqyb 547 16 the the DT cord-023726-2fduzqyb 547 17 nucleic nucleic JJ cord-023726-2fduzqyb 547 18 acid acid NN cord-023726-2fduzqyb 547 19 charge charge NN cord-023726-2fduzqyb 547 20 . . . cord-023726-2fduzqyb 548 1 The the DT cord-023726-2fduzqyb 548 2 DNA dna NN cord-023726-2fduzqyb 548 3 in in IN cord-023726-2fduzqyb 548 4 the the DT cord-023726-2fduzqyb 548 5 virions virion NNS cord-023726-2fduzqyb 548 6 of of IN cord-023726-2fduzqyb 548 7 the the DT cord-023726-2fduzqyb 548 8 polyomaviruses polyomaviruse NNS cord-023726-2fduzqyb 548 9 is be VBZ cord-023726-2fduzqyb 548 10 complexed complexe VBN cord-023726-2fduzqyb 548 11 with with IN cord-023726-2fduzqyb 548 12 cellular cellular JJ cord-023726-2fduzqyb 548 13 histones histone NNS cord-023726-2fduzqyb 548 14 . . . cord-023726-2fduzqyb 549 1 The the DT cord-023726-2fduzqyb 549 2 viral viral JJ cord-023726-2fduzqyb 549 3 genomes genome NNS cord-023726-2fduzqyb 549 4 in in IN cord-023726-2fduzqyb 549 5 these these DT cord-023726-2fduzqyb 549 6 viruses virus NNS cord-023726-2fduzqyb 549 7 have have VBP cord-023726-2fduzqyb 549 8 been be VBN cord-023726-2fduzqyb 549 9 referred refer VBN cord-023726-2fduzqyb 549 10 to to IN cord-023726-2fduzqyb 549 11 as as IN cord-023726-2fduzqyb 549 12 minichromosomes minichromosomes NNP cord-023726-2fduzqyb 549 13 . . . cord-023726-2fduzqyb 550 1 In in IN cord-023726-2fduzqyb 550 2 contrast contrast NN cord-023726-2fduzqyb 550 3 , , , cord-023726-2fduzqyb 550 4 the the DT cord-023726-2fduzqyb 550 5 adenoviruses adenovirus NNS cord-023726-2fduzqyb 550 6 encode encode VBP cord-023726-2fduzqyb 550 7 their -PRON- PRP$ cord-023726-2fduzqyb 550 8 own own JJ cord-023726-2fduzqyb 550 9 basic basic JJ cord-023726-2fduzqyb 550 10 proteins protein NNS cord-023726-2fduzqyb 550 11 that that WDT cord-023726-2fduzqyb 550 12 complex complex VBP cord-023726-2fduzqyb 550 13 with with IN cord-023726-2fduzqyb 550 14 the the DT cord-023726-2fduzqyb 550 15 genome genome NN cord-023726-2fduzqyb 550 16 in in IN cord-023726-2fduzqyb 550 17 the the DT cord-023726-2fduzqyb 550 18 core core NN cord-023726-2fduzqyb 550 19 of of IN cord-023726-2fduzqyb 550 20 the the DT cord-023726-2fduzqyb 550 21 virion virion NN cord-023726-2fduzqyb 550 22 . . . cord-023726-2fduzqyb 551 1 Another another DT cord-023726-2fduzqyb 551 2 strategy strategy NN cord-023726-2fduzqyb 551 3 is be VBZ cord-023726-2fduzqyb 551 4 used use VBN cord-023726-2fduzqyb 551 5 by by IN cord-023726-2fduzqyb 551 6 the the DT cord-023726-2fduzqyb 551 7 herpesviruses herpesviruse NNS cord-023726-2fduzqyb 551 8 , , , cord-023726-2fduzqyb 551 9 which which WDT cord-023726-2fduzqyb 551 10 incorporate incorporate VBP cord-023726-2fduzqyb 551 11 polyamines polyamine NNS cord-023726-2fduzqyb 551 12 into into IN cord-023726-2fduzqyb 551 13 the the DT cord-023726-2fduzqyb 551 14 virion virion NN cord-023726-2fduzqyb 551 15 . . . cord-023726-2fduzqyb 552 1 Herpes Herpes NNP cord-023726-2fduzqyb 552 2 simplex simplex NN cord-023726-2fduzqyb 552 3 virus virus NN cord-023726-2fduzqyb 552 4 has have VBZ cord-023726-2fduzqyb 552 5 been be VBN cord-023726-2fduzqyb 552 6 estimated estimate VBN cord-023726-2fduzqyb 552 7 to to TO cord-023726-2fduzqyb 552 8 incorporate incorporate VB cord-023726-2fduzqyb 552 9 70,000 70,000 CD cord-023726-2fduzqyb 552 10 molecules molecule NNS cord-023726-2fduzqyb 552 11 of of IN cord-023726-2fduzqyb 552 12 spermidine spermidine NN cord-023726-2fduzqyb 552 13 and and CC cord-023726-2fduzqyb 552 14 40,000 40,000 CD cord-023726-2fduzqyb 552 15 molecules molecule NNS cord-023726-2fduzqyb 552 16 of of IN cord-023726-2fduzqyb 552 17 spermine spermine NNP cord-023726-2fduzqyb 552 18 , , , cord-023726-2fduzqyb 552 19 which which WDT cord-023726-2fduzqyb 552 20 would would MD cord-023726-2fduzqyb 552 21 be be VB cord-023726-2fduzqyb 552 22 sufficient sufficient JJ cord-023726-2fduzqyb 552 23 to to TO cord-023726-2fduzqyb 552 24 neutralize neutralize VB cord-023726-2fduzqyb 552 25 about about RB cord-023726-2fduzqyb 552 26 40 40 CD cord-023726-2fduzqyb 552 27 % % NN cord-023726-2fduzqyb 552 28 of of IN cord-023726-2fduzqyb 552 29 the the DT cord-023726-2fduzqyb 552 30 DNA dna NN cord-023726-2fduzqyb 552 31 charge charge NN cord-023726-2fduzqyb 552 32 . . . cord-023726-2fduzqyb 553 1 Among among IN cord-023726-2fduzqyb 553 2 RNA RNA NNP cord-023726-2fduzqyb 553 3 viruses virus NNS cord-023726-2fduzqyb 553 4 , , , cord-023726-2fduzqyb 553 5 the the DT cord-023726-2fduzqyb 553 6 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 553 7 proteins protein NNS cord-023726-2fduzqyb 553 8 are be VBP cord-023726-2fduzqyb 553 9 often often RB cord-023726-2fduzqyb 553 10 quite quite RB cord-023726-2fduzqyb 553 11 basic basic JJ cord-023726-2fduzqyb 553 12 and and CC cord-023726-2fduzqyb 553 13 neutralize neutralize VBP cord-023726-2fduzqyb 553 14 part part NN cord-023726-2fduzqyb 553 15 of of IN cord-023726-2fduzqyb 553 16 the the DT cord-023726-2fduzqyb 553 17 charge charge NN cord-023726-2fduzqyb 553 18 on on IN cord-023726-2fduzqyb 553 19 the the DT cord-023726-2fduzqyb 553 20 RNA RNA NNP cord-023726-2fduzqyb 553 21 . . . cord-023726-2fduzqyb 554 1 As as IN cord-023726-2fduzqyb 554 2 one one CD cord-023726-2fduzqyb 554 3 example example NN cord-023726-2fduzqyb 554 4 , , , cord-023726-2fduzqyb 554 5 the the DT cord-023726-2fduzqyb 554 6 N n CD cord-023726-2fduzqyb 554 7 - - HYPH cord-023726-2fduzqyb 554 8 terminal terminal NN cord-023726-2fduzqyb 554 9 110 110 CD cord-023726-2fduzqyb 554 10 amino amino JJ cord-023726-2fduzqyb 554 11 acids acid NNS cord-023726-2fduzqyb 554 12 of of IN cord-023726-2fduzqyb 554 13 the the DT cord-023726-2fduzqyb 554 14 capsid capsid JJ cord-023726-2fduzqyb 554 15 protein protein NN cord-023726-2fduzqyb 554 16 of of IN cord-023726-2fduzqyb 554 17 Sindbis Sindbis NNP cord-023726-2fduzqyb 554 18 virus virus NN cord-023726-2fduzqyb 554 19 have have VBP cord-023726-2fduzqyb 554 20 a a DT cord-023726-2fduzqyb 554 21 net net JJ cord-023726-2fduzqyb 554 22 positive positive JJ cord-023726-2fduzqyb 554 23 charge charge NN cord-023726-2fduzqyb 554 24 of of IN cord-023726-2fduzqyb 554 25 29 29 CD cord-023726-2fduzqyb 554 26 . . . cord-023726-2fduzqyb 555 1 The the DT cord-023726-2fduzqyb 555 2 positive positive JJ cord-023726-2fduzqyb 555 3 charges charge NNS cord-023726-2fduzqyb 555 4 within within IN cord-023726-2fduzqyb 555 5 this this DT cord-023726-2fduzqyb 555 6 domain domain NN cord-023726-2fduzqyb 555 7 of of IN cord-023726-2fduzqyb 555 8 the the DT cord-023726-2fduzqyb 555 9 240 240 CD cord-023726-2fduzqyb 555 10 capsid capsid NN cord-023726-2fduzqyb 555 11 proteins protein NNS cord-023726-2fduzqyb 555 12 in in IN cord-023726-2fduzqyb 555 13 a a DT cord-023726-2fduzqyb 555 14 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 555 15 would would MD cord-023726-2fduzqyb 555 16 be be VB cord-023726-2fduzqyb 555 17 sufficient sufficient JJ cord-023726-2fduzqyb 555 18 to to TO cord-023726-2fduzqyb 555 19 neutralize neutralize VB cord-023726-2fduzqyb 555 20 about about RB cord-023726-2fduzqyb 555 21 60 60 CD cord-023726-2fduzqyb 555 22 % % NN cord-023726-2fduzqyb 555 23 of of IN cord-023726-2fduzqyb 555 24 the the DT cord-023726-2fduzqyb 555 25 charge charge NN cord-023726-2fduzqyb 555 26 on on IN cord-023726-2fduzqyb 555 27 the the DT cord-023726-2fduzqyb 555 28 RNA RNA NNP cord-023726-2fduzqyb 555 29 genome genome NN cord-023726-2fduzqyb 555 30 . . . cord-023726-2fduzqyb 556 1 This this DT cord-023726-2fduzqyb 556 2 charged charge VBN cord-023726-2fduzqyb 556 3 domain domain NN cord-023726-2fduzqyb 556 4 is be VBZ cord-023726-2fduzqyb 556 5 thought think VBN cord-023726-2fduzqyb 556 6 to to TO cord-023726-2fduzqyb 556 7 penetrate penetrate VB cord-023726-2fduzqyb 556 8 into into IN cord-023726-2fduzqyb 556 9 the the DT cord-023726-2fduzqyb 556 10 interior interior NN cord-023726-2fduzqyb 556 11 of of IN cord-023726-2fduzqyb 556 12 the the DT cord-023726-2fduzqyb 556 13 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 556 14 and and CC cord-023726-2fduzqyb 556 15 complex complex JJ cord-023726-2fduzqyb 556 16 with with IN cord-023726-2fduzqyb 556 17 the the DT cord-023726-2fduzqyb 556 18 viral viral JJ cord-023726-2fduzqyb 556 19 RNA RNA NNP cord-023726-2fduzqyb 556 20 . . . cord-023726-2fduzqyb 557 1 Virions virion NNS cord-023726-2fduzqyb 557 2 differ differ VBP cord-023726-2fduzqyb 557 3 greatly greatly RB cord-023726-2fduzqyb 557 4 in in IN cord-023726-2fduzqyb 557 5 stability stability NN cord-023726-2fduzqyb 557 6 , , , cord-023726-2fduzqyb 557 7 and and CC cord-023726-2fduzqyb 557 8 these these DT cord-023726-2fduzqyb 557 9 differences difference NNS cord-023726-2fduzqyb 557 10 are be VBP cord-023726-2fduzqyb 557 11 often often RB cord-023726-2fduzqyb 557 12 correlated correlate VBN cord-023726-2fduzqyb 557 13 with with IN cord-023726-2fduzqyb 557 14 the the DT cord-023726-2fduzqyb 557 15 means mean NNS cord-023726-2fduzqyb 557 16 by by IN cord-023726-2fduzqyb 557 17 which which WDT cord-023726-2fduzqyb 557 18 viruses virus NNS cord-023726-2fduzqyb 557 19 infect infect VBP cord-023726-2fduzqyb 557 20 new new JJ cord-023726-2fduzqyb 557 21 hosts host NNS cord-023726-2fduzqyb 557 22 . . . cord-023726-2fduzqyb 558 1 Viruses virus NNS cord-023726-2fduzqyb 558 2 that that WDT cord-023726-2fduzqyb 558 3 must must MD cord-023726-2fduzqyb 558 4 persist persist VB cord-023726-2fduzqyb 558 5 in in IN cord-023726-2fduzqyb 558 6 the the DT cord-023726-2fduzqyb 558 7 extracellular extracellular JJ cord-023726-2fduzqyb 558 8 environment environment NN cord-023726-2fduzqyb 558 9 for for IN cord-023726-2fduzqyb 558 10 considerable considerable JJ cord-023726-2fduzqyb 558 11 periods period NNS cord-023726-2fduzqyb 558 12 , , , cord-023726-2fduzqyb 558 13 for for IN cord-023726-2fduzqyb 558 14 example example NN cord-023726-2fduzqyb 558 15 , , , cord-023726-2fduzqyb 558 16 must must MD cord-023726-2fduzqyb 558 17 be be VB cord-023726-2fduzqyb 558 18 more more RBR cord-023726-2fduzqyb 558 19 stable stable JJ cord-023726-2fduzqyb 558 20 than than IN cord-023726-2fduzqyb 558 21 viruses virus NNS cord-023726-2fduzqyb 558 22 that that WDT cord-023726-2fduzqyb 558 23 pass pass VBP cord-023726-2fduzqyb 558 24 quickly quickly RB cord-023726-2fduzqyb 558 25 from from IN cord-023726-2fduzqyb 558 26 one one CD cord-023726-2fduzqyb 558 27 host host NN cord-023726-2fduzqyb 558 28 to to IN cord-023726-2fduzqyb 558 29 the the DT cord-023726-2fduzqyb 558 30 next next JJ cord-023726-2fduzqyb 558 31 . . . cord-023726-2fduzqyb 559 1 As as IN cord-023726-2fduzqyb 559 2 an an DT cord-023726-2fduzqyb 559 3 example example NN cord-023726-2fduzqyb 559 4 of of IN cord-023726-2fduzqyb 559 5 such such JJ cord-023726-2fduzqyb 559 6 requirements requirement NNS cord-023726-2fduzqyb 559 7 , , , cord-023726-2fduzqyb 559 8 consider consider VB cord-023726-2fduzqyb 559 9 the the DT cord-023726-2fduzqyb 559 10 closely closely RB cord-023726-2fduzqyb 559 11 related relate VBN cord-023726-2fduzqyb 559 12 polioviruses poliovirus NNS cord-023726-2fduzqyb 559 13 and and CC cord-023726-2fduzqyb 559 14 rhinoviruses rhinovirus NNS cord-023726-2fduzqyb 559 15 , , , cord-023726-2fduzqyb 559 16 members member NNS cord-023726-2fduzqyb 559 17 of of IN cord-023726-2fduzqyb 559 18 two two CD cord-023726-2fduzqyb 559 19 different different JJ cord-023726-2fduzqyb 559 20 genera genus NNS cord-023726-2fduzqyb 559 21 of of IN cord-023726-2fduzqyb 559 22 the the DT cord-023726-2fduzqyb 559 23 family family NN cord-023726-2fduzqyb 559 24 Picornaviridae Picornaviridae NNP cord-023726-2fduzqyb 559 25 . . . cord-023726-2fduzqyb 560 1 These these DT cord-023726-2fduzqyb 560 2 viruses virus NNS cord-023726-2fduzqyb 560 3 shared share VBD cord-023726-2fduzqyb 560 4 a a DT cord-023726-2fduzqyb 560 5 common common JJ cord-023726-2fduzqyb 560 6 ancestor ancestor NN cord-023726-2fduzqyb 560 7 in in IN cord-023726-2fduzqyb 560 8 the the DT cord-023726-2fduzqyb 560 9 not not RB cord-023726-2fduzqyb 560 10 too too RB cord-023726-2fduzqyb 560 11 distant distant JJ cord-023726-2fduzqyb 560 12 past past NN cord-023726-2fduzqyb 560 13 and and CC cord-023726-2fduzqyb 560 14 have have VBP cord-023726-2fduzqyb 560 15 structures structure NNS cord-023726-2fduzqyb 560 16 that that WDT cord-023726-2fduzqyb 560 17 are be VBP cord-023726-2fduzqyb 560 18 very very RB cord-023726-2fduzqyb 560 19 similar similar JJ cord-023726-2fduzqyb 560 20 . . . cord-023726-2fduzqyb 561 1 The the DT cord-023726-2fduzqyb 561 2 polioviruses poliovirus NNS cord-023726-2fduzqyb 561 3 are be VBP cord-023726-2fduzqyb 561 4 spread spread VBN cord-023726-2fduzqyb 561 5 by by IN cord-023726-2fduzqyb 561 6 an an DT cord-023726-2fduzqyb 561 7 oral oral JJ cord-023726-2fduzqyb 561 8 - - HYPH cord-023726-2fduzqyb 561 9 fecal fecal NN cord-023726-2fduzqyb 561 10 route route NN cord-023726-2fduzqyb 561 11 and and CC cord-023726-2fduzqyb 561 12 have have VB cord-023726-2fduzqyb 561 13 the the DT cord-023726-2fduzqyb 561 14 ability ability NN cord-023726-2fduzqyb 561 15 to to TO cord-023726-2fduzqyb 561 16 persist persist VB cord-023726-2fduzqyb 561 17 in in IN cord-023726-2fduzqyb 561 18 a a DT cord-023726-2fduzqyb 561 19 hostile hostile JJ cord-023726-2fduzqyb 561 20 extracellular extracellular JJ cord-023726-2fduzqyb 561 21 environment environment NN cord-023726-2fduzqyb 561 22 for for IN cord-023726-2fduzqyb 561 23 some some DT cord-023726-2fduzqyb 561 24 time time NN cord-023726-2fduzqyb 561 25 where where WRB cord-023726-2fduzqyb 561 26 they -PRON- PRP cord-023726-2fduzqyb 561 27 may may MD cord-023726-2fduzqyb 561 28 contaminate contaminate VB cord-023726-2fduzqyb 561 29 drinking drinking NN cord-023726-2fduzqyb 561 30 water water NN cord-023726-2fduzqyb 561 31 or or CC cord-023726-2fduzqyb 561 32 food food NN cord-023726-2fduzqyb 561 33 . . . cord-023726-2fduzqyb 562 1 Furthermore furthermore RB cord-023726-2fduzqyb 562 2 , , , cord-023726-2fduzqyb 562 3 they -PRON- PRP cord-023726-2fduzqyb 562 4 must must MD cord-023726-2fduzqyb 562 5 pass pass VB cord-023726-2fduzqyb 562 6 through through IN cord-023726-2fduzqyb 562 7 the the DT cord-023726-2fduzqyb 562 8 stomach stomach NN cord-023726-2fduzqyb 562 9 , , , cord-023726-2fduzqyb 562 10 where where WRB cord-023726-2fduzqyb 562 11 the the DT cord-023726-2fduzqyb 562 12 pH pH NNP cord-023726-2fduzqyb 562 13 is be VBZ cord-023726-2fduzqyb 562 14 less less JJR cord-023726-2fduzqyb 562 15 than than IN cord-023726-2fduzqyb 562 16 2 2 CD cord-023726-2fduzqyb 562 17 , , , cord-023726-2fduzqyb 562 18 to to TO cord-023726-2fduzqyb 562 19 reach reach VB cord-023726-2fduzqyb 562 20 the the DT cord-023726-2fduzqyb 562 21 intestinal intestinal JJ cord-023726-2fduzqyb 562 22 tract tract NN cord-023726-2fduzqyb 562 23 where where WRB cord-023726-2fduzqyb 562 24 they -PRON- PRP cord-023726-2fduzqyb 562 25 begin begin VBP cord-023726-2fduzqyb 562 26 the the DT cord-023726-2fduzqyb 562 27 infection infection NN cord-023726-2fduzqyb 562 28 cycle cycle NN cord-023726-2fduzqyb 562 29 . . . cord-023726-2fduzqyb 563 1 It -PRON- PRP cord-023726-2fduzqyb 563 2 is be VBZ cord-023726-2fduzqyb 563 3 not not RB cord-023726-2fduzqyb 563 4 surprising surprising JJ cord-023726-2fduzqyb 563 5 , , , cord-023726-2fduzqyb 563 6 therefore therefore RB cord-023726-2fduzqyb 563 7 , , , cord-023726-2fduzqyb 563 8 that that IN cord-023726-2fduzqyb 563 9 the the DT cord-023726-2fduzqyb 563 10 poliovirion poliovirion NN cord-023726-2fduzqyb 563 11 is be VBZ cord-023726-2fduzqyb 563 12 stable stable JJ cord-023726-2fduzqyb 563 13 to to IN cord-023726-2fduzqyb 563 14 storage storage NN cord-023726-2fduzqyb 563 15 and and CC cord-023726-2fduzqyb 563 16 to to IN cord-023726-2fduzqyb 563 17 treatments treatment NNS cord-023726-2fduzqyb 563 18 such such JJ cord-023726-2fduzqyb 563 19 as as IN cord-023726-2fduzqyb 563 20 exposure exposure NN cord-023726-2fduzqyb 563 21 to to IN cord-023726-2fduzqyb 563 22 mild mild JJ cord-023726-2fduzqyb 563 23 detergents detergent NNS cord-023726-2fduzqyb 563 24 or or CC cord-023726-2fduzqyb 563 25 to to IN cord-023726-2fduzqyb 563 26 pH ph NN cord-023726-2fduzqyb 563 27 < < XX cord-023726-2fduzqyb 563 28 2 2 CD cord-023726-2fduzqyb 563 29 . . . cord-023726-2fduzqyb 564 1 In in IN cord-023726-2fduzqyb 564 2 contrast contrast NN cord-023726-2fduzqyb 564 3 , , , cord-023726-2fduzqyb 564 4 rhinoviruses rhinovirus NNS cord-023726-2fduzqyb 564 5 are be VBP cord-023726-2fduzqyb 564 6 spread spread VBN cord-023726-2fduzqyb 564 7 by by IN cord-023726-2fduzqyb 564 8 aerosols aerosol NNS cord-023726-2fduzqyb 564 9 or or CC cord-023726-2fduzqyb 564 10 contaminated contaminated JJ cord-023726-2fduzqyb 564 11 mucus mucus NN cord-023726-2fduzqyb 564 12 , , , cord-023726-2fduzqyb 564 13 and and CC cord-023726-2fduzqyb 564 14 spread spread VBN cord-023726-2fduzqyb 564 15 normally normally RB cord-023726-2fduzqyb 564 16 requires require VBZ cord-023726-2fduzqyb 564 17 close close JJ cord-023726-2fduzqyb 564 18 contact contact NN cord-023726-2fduzqyb 564 19 . . . cord-023726-2fduzqyb 565 1 The the DT cord-023726-2fduzqyb 565 2 rhinovirion rhinovirion NN cord-023726-2fduzqyb 565 3 is be VBZ cord-023726-2fduzqyb 565 4 less less RBR cord-023726-2fduzqyb 565 5 stable stable JJ cord-023726-2fduzqyb 565 6 than than IN cord-023726-2fduzqyb 565 7 the the DT cord-023726-2fduzqyb 565 8 poliovirion poliovirion NN cord-023726-2fduzqyb 565 9 . . . cord-023726-2fduzqyb 566 1 It -PRON- PRP cord-023726-2fduzqyb 566 2 survives survive VBZ cord-023726-2fduzqyb 566 3 for for IN cord-023726-2fduzqyb 566 4 only only RB cord-023726-2fduzqyb 566 5 a a DT cord-023726-2fduzqyb 566 6 limited limited JJ cord-023726-2fduzqyb 566 7 period period NN cord-023726-2fduzqyb 566 8 of of IN cord-023726-2fduzqyb 566 9 time time NN cord-023726-2fduzqyb 566 10 in in IN cord-023726-2fduzqyb 566 11 the the DT cord-023726-2fduzqyb 566 12 external external JJ cord-023726-2fduzqyb 566 13 environment environment NN cord-023726-2fduzqyb 566 14 and and CC cord-023726-2fduzqyb 566 15 is be VBZ cord-023726-2fduzqyb 566 16 sensitive sensitive JJ cord-023726-2fduzqyb 566 17 to to IN cord-023726-2fduzqyb 566 18 treatment treatment NN cord-023726-2fduzqyb 566 19 with with IN cord-023726-2fduzqyb 566 20 detergents detergent NNS cord-023726-2fduzqyb 566 21 or or CC cord-023726-2fduzqyb 566 22 exposure exposure NN cord-023726-2fduzqyb 566 23 to to IN cord-023726-2fduzqyb 566 24 pH ph NN cord-023726-2fduzqyb 566 25 3 3 CD cord-023726-2fduzqyb 566 26 . . . cord-023726-2fduzqyb 567 1 General General NNP cord-023726-2fduzqyb 567 2 Structure Structure NNP cord-023726-2fduzqyb 567 3 of of IN cord-023726-2fduzqyb 567 4 Viruses Viruses NNP cord-023726-2fduzqyb 567 5 Thin thin JJ cord-023726-2fduzqyb 567 6 section section NN cord-023726-2fduzqyb 567 7 of of IN cord-023726-2fduzqyb 567 8 a a DT cord-023726-2fduzqyb 567 9 herpes herpes NN cord-023726-2fduzqyb 567 10 simplex simplex NN cord-023726-2fduzqyb 567 11 virion virion NN cord-023726-2fduzqyb 567 12 ( ( -LRB- cord-023726-2fduzqyb 567 13 Herpesviridae Herpesviridae NNP cord-023726-2fduzqyb 567 14 ) ) -RRB- cord-023726-2fduzqyb 567 15 in in IN cord-023726-2fduzqyb 567 16 an an DT cord-023726-2fduzqyb 567 17 infected infected JJ cord-023726-2fduzqyb 567 18 Hep-2 Hep-2 NNP cord-023726-2fduzqyb 567 19 cell cell NN cord-023726-2fduzqyb 567 20 . . . cord-023726-2fduzqyb 568 1 The the DT cord-023726-2fduzqyb 568 2 particle particle NN cord-023726-2fduzqyb 568 3 is be VBZ cord-023726-2fduzqyb 568 4 apparently apparently RB cord-023726-2fduzqyb 568 5 coated coat VBN cord-023726-2fduzqyb 568 6 with with IN cord-023726-2fduzqyb 568 7 an an DT cord-023726-2fduzqyb 568 8 inner inner JJ cord-023726-2fduzqyb 568 9 envelope envelope NN cord-023726-2fduzqyb 568 10 , , , cord-023726-2fduzqyb 568 11 and and CC cord-023726-2fduzqyb 568 12 is be VBZ cord-023726-2fduzqyb 568 13 in in IN cord-023726-2fduzqyb 568 14 the the DT cord-023726-2fduzqyb 568 15 process process NN cord-023726-2fduzqyb 568 16 of of IN cord-023726-2fduzqyb 568 17 acquiring acquire VBG cord-023726-2fduzqyb 568 18 its -PRON- PRP$ cord-023726-2fduzqyb 568 19 outer outer JJ cord-023726-2fduzqyb 568 20 envelope envelope NN cord-023726-2fduzqyb 568 21 from from IN cord-023726-2fduzqyb 568 22 the the DT cord-023726-2fduzqyb 568 23 nuclear nuclear JJ cord-023726-2fduzqyb 568 24 membrane membrane NN cord-023726-2fduzqyb 568 25 . . . cord-023726-2fduzqyb 569 1 From from IN cord-023726-2fduzqyb 569 2 Roizman Roizman NNP cord-023726-2fduzqyb 569 3 ( ( -LRB- cord-023726-2fduzqyb 569 4 1969 1969 CD cord-023726-2fduzqyb 569 5 ) ) -RRB- cord-023726-2fduzqyb 569 6 . . . cord-023726-2fduzqyb 570 1 ( ( -LRB- cord-023726-2fduzqyb 570 2 B b NN cord-023726-2fduzqyb 570 3 ) ) -RRB- cord-023726-2fduzqyb 570 4 Machupo Machupo NNP cord-023726-2fduzqyb 570 5 virus virus NN cord-023726-2fduzqyb 570 6 ( ( -LRB- cord-023726-2fduzqyb 570 7 Arenaviridae Arenaviridae NNP cord-023726-2fduzqyb 570 8 ) ) -RRB- cord-023726-2fduzqyb 570 9 budding bud VBG cord-023726-2fduzqyb 570 10 from from IN cord-023726-2fduzqyb 570 11 a a DT cord-023726-2fduzqyb 570 12 Raji Raji NNP cord-023726-2fduzqyb 570 13 cell cell NN cord-023726-2fduzqyb 570 14 . . . cord-023726-2fduzqyb 571 1 From from IN cord-023726-2fduzqyb 571 2 Murphy Murphy NNP cord-023726-2fduzqyb 571 3 et et NNP cord-023726-2fduzqyb 571 4 al al NNP cord-023726-2fduzqyb 571 5 . . . cord-023726-2fduzqyb 572 1 ( ( -LRB- cord-023726-2fduzqyb 572 2 1969 1969 CD cord-023726-2fduzqyb 572 3 ) ) -RRB- cord-023726-2fduzqyb 572 4 . . . cord-023726-2fduzqyb 573 1 ( ( -LRB- cord-023726-2fduzqyb 573 2 Magnification magnification NN cord-023726-2fduzqyb 573 3 : : : cord-023726-2fduzqyb 573 4 120,000× 120,000× LS cord-023726-2fduzqyb 573 5 ) ) -RRB- cord-023726-2fduzqyb 573 6 . . . cord-023726-2fduzqyb 574 1 ( ( -LRB- cord-023726-2fduzqyb 574 2 C C NNP cord-023726-2fduzqyb 574 3 ) ) -RRB- cord-023726-2fduzqyb 574 4 Sindbis Sindbis NNP cord-023726-2fduzqyb 574 5 virus virus NN cord-023726-2fduzqyb 574 6 ( ( -LRB- cord-023726-2fduzqyb 574 7 Togaviridae Togaviridae NNP cord-023726-2fduzqyb 574 8 ) ) -RRB- cord-023726-2fduzqyb 574 9 budding bud VBG cord-023726-2fduzqyb 574 10 from from IN cord-023726-2fduzqyb 574 11 the the DT cord-023726-2fduzqyb 574 12 plasma plasma NN cord-023726-2fduzqyb 574 13 membrane membrane NN cord-023726-2fduzqyb 574 14 of of IN cord-023726-2fduzqyb 574 15 an an DT cord-023726-2fduzqyb 574 16 infected infected JJ cord-023726-2fduzqyb 574 17 chicken chicken NN cord-023726-2fduzqyb 574 18 cell cell NN cord-023726-2fduzqyb 574 19 000× 000× CD cord-023726-2fduzqyb 574 20 ) ) -RRB- cord-023726-2fduzqyb 574 21 . . . cord-023726-2fduzqyb 575 1 ( ( -LRB- cord-023726-2fduzqyb 575 2 E e NN cord-023726-2fduzqyb 575 3 ) ) -RRB- cord-023726-2fduzqyb 576 1 A a DT cord-023726-2fduzqyb 576 2 portion portion NN cord-023726-2fduzqyb 576 3 of of IN cord-023726-2fduzqyb 576 4 the the DT cord-023726-2fduzqyb 576 5 cell cell NN cord-023726-2fduzqyb 576 6 surface surface NN cord-023726-2fduzqyb 576 7 with with IN cord-023726-2fduzqyb 576 8 SV5 sv5 JJ cord-023726-2fduzqyb 576 9 filaments filament NNS cord-023726-2fduzqyb 576 10 ( ( -LRB- cord-023726-2fduzqyb 576 11 Paramyxoviridae Paramyxoviridae NNP cord-023726-2fduzqyb 576 12 ) ) -RRB- cord-023726-2fduzqyb 576 13 in in IN cord-023726-2fduzqyb 576 14 the the DT cord-023726-2fduzqyb 576 15 process process NN cord-023726-2fduzqyb 576 16 of of IN cord-023726-2fduzqyb 576 17 budding bud VBG cord-023726-2fduzqyb 576 18 . . . cord-023726-2fduzqyb 577 1 From from IN cord-023726-2fduzqyb 577 2 Compans Compans NNPS cord-023726-2fduzqyb 577 3 and and CC cord-023726-2fduzqyb 577 4 Choppin Choppin NNP cord-023726-2fduzqyb 577 5 ( ( -LRB- cord-023726-2fduzqyb 577 6 1973 1973 CD cord-023726-2fduzqyb 577 7 ) ) -RRB- cord-023726-2fduzqyb 577 8 . . . cord-023726-2fduzqyb 578 1 ( ( -LRB- cord-023726-2fduzqyb 578 2 45,000 45,000 CD cord-023726-2fduzqyb 578 3 × × NN cord-023726-2fduzqyb 578 4 ) ) -RRB- cord-023726-2fduzqyb 578 5 . . . cord-023726-2fduzqyb 579 1 ( ( -LRB- cord-023726-2fduzqyb 579 2 F F NNP cord-023726-2fduzqyb 579 3 ) ) -RRB- cord-023726-2fduzqyb 579 4 A a DT cord-023726-2fduzqyb 579 5 row row NN cord-023726-2fduzqyb 579 6 of of IN cord-023726-2fduzqyb 579 7 SV5 sv5 JJ cord-023726-2fduzqyb 579 8 virions virion NNS cord-023726-2fduzqyb 579 9 budding bud VBG cord-023726-2fduzqyb 579 10 from from IN cord-023726-2fduzqyb 579 11 the the DT cord-023726-2fduzqyb 579 12 surface surface NN cord-023726-2fduzqyb 579 13 of of IN cord-023726-2fduzqyb 579 14 a a DT cord-023726-2fduzqyb 579 15 monkey monkey NN cord-023726-2fduzqyb 579 16 kidney kidney NN cord-023726-2fduzqyb 579 17 cell cell NN cord-023726-2fduzqyb 579 18 . . . cord-023726-2fduzqyb 580 1 Cross cross NN cord-023726-2fduzqyb 580 2 sections section NNS cord-023726-2fduzqyb 580 3 of of IN cord-023726-2fduzqyb 580 4 the the DT cord-023726-2fduzqyb 580 5 nucleocapsid nucleocapsid NN cord-023726-2fduzqyb 580 6 can can MD cord-023726-2fduzqyb 580 7 be be VB cord-023726-2fduzqyb 580 8 seen see VBN cord-023726-2fduzqyb 580 9 within within IN cord-023726-2fduzqyb 580 10 several several JJ cord-023726-2fduzqyb 580 11 of of IN cord-023726-2fduzqyb 580 12 the the DT cord-023726-2fduzqyb 580 13 particles particle NNS cord-023726-2fduzqyb 580 14 Principles principle NNS cord-023726-2fduzqyb 580 15 of of IN cord-023726-2fduzqyb 580 16 virus virus NN cord-023726-2fduzqyb 580 17 structure structure NN cord-023726-2fduzqyb 580 18 Functional functional JJ cord-023726-2fduzqyb 580 19 implications implication NNS cord-023726-2fduzqyb 580 20 of of IN cord-023726-2fduzqyb 580 21 protein protein NN cord-023726-2fduzqyb 580 22 - - HYPH cord-023726-2fduzqyb 580 23 protein protein NN cord-023726-2fduzqyb 580 24 interactions interaction NNS cord-023726-2fduzqyb 580 25 in in IN cord-023726-2fduzqyb 580 26 icosahedral icosahedral JJ cord-023726-2fduzqyb 580 27 viruses virus NNS cord-023726-2fduzqyb 580 28 Principles Principles NNPS cord-023726-2fduzqyb 580 29 of of IN cord-023726-2fduzqyb 580 30 Virus Virus NNP cord-023726-2fduzqyb 580 31 Structure Structure NNP cord-023726-2fduzqyb 580 32 Structural Structural NNP cord-023726-2fduzqyb 580 33 Biology Biology NNP cord-023726-2fduzqyb 580 34 of of IN cord-023726-2fduzqyb 580 35 Viruses Viruses NNPS cord-023726-2fduzqyb 580 36 Ultrastructure Ultrastructure NNP cord-023726-2fduzqyb 580 37 of of IN cord-023726-2fduzqyb 580 38 Animal Animal NNP cord-023726-2fduzqyb 580 39 Viruses Viruses NNPS cord-023726-2fduzqyb 580 40 and and CC cord-023726-2fduzqyb 580 41 Bacteriophages Bacteriophages NNPS cord-023726-2fduzqyb 580 42 : : : cord-023726-2fduzqyb 580 43 An an DT cord-023726-2fduzqyb 580 44 Atlas Atlas NNP cord-023726-2fduzqyb 580 45 . . . cord-023726-2fduzqyb 581 1 Ultrastructure Ultrastructure NNP cord-023726-2fduzqyb 581 2 in in IN cord-023726-2fduzqyb 581 3 Biological Biological NNP cord-023726-2fduzqyb 581 4 Systems Systems NNPS cord-023726-2fduzqyb 581 5 Cryoelectron Cryoelectron NNP cord-023726-2fduzqyb 581 6 Microscopy Microscopy NNP cord-023726-2fduzqyb 582 1 Adding add VBG cord-023726-2fduzqyb 582 2 the the DT cord-023726-2fduzqyb 582 3 third third JJ cord-023726-2fduzqyb 582 4 dimension dimension NN cord-023726-2fduzqyb 582 5 to to IN cord-023726-2fduzqyb 582 6 virus virus NN cord-023726-2fduzqyb 582 7 life life NN cord-023726-2fduzqyb 582 8 cycles cycle NNS cord-023726-2fduzqyb 582 9 : : : cord-023726-2fduzqyb 582 10 Three three CD cord-023726-2fduzqyb 582 11 - - HYPH cord-023726-2fduzqyb 582 12 dimensional dimensional JJ cord-023726-2fduzqyb 582 13 reconstruction reconstruction NN cord-023726-2fduzqyb 582 14 of of IN cord-023726-2fduzqyb 582 15 icosahedral icosahedral JJ cord-023726-2fduzqyb 582 16 viruses virus NNS cord-023726-2fduzqyb 582 17 from from IN cord-023726-2fduzqyb 582 18 cryo cryo NN cord-023726-2fduzqyb 582 19 - - HYPH cord-023726-2fduzqyb 582 20 electron electron NN cord-023726-2fduzqyb 582 21 micrographs micrograph NNS cord-023726-2fduzqyb 582 22 . . . cord-023726-2fduzqyb 583 1 Microbiol Microbiol NNP cord-023726-2fduzqyb 583 2 Membrane Membrane NNP cord-023726-2fduzqyb 583 3 proteins protein NNS cord-023726-2fduzqyb 583 4 organize organize VBP cord-023726-2fduzqyb 583 5 a a DT cord-023726-2fduzqyb 583 6 symmetrical symmetrical JJ cord-023726-2fduzqyb 583 7 virus virus NN cord-023726-2fduzqyb 583 8 Mapping map VBG cord-023726-2fduzqyb 583 9 the the DT cord-023726-2fduzqyb 583 10 structure structure NN cord-023726-2fduzqyb 583 11 and and CC cord-023726-2fduzqyb 583 12 function function NN cord-023726-2fduzqyb 583 13 of of IN cord-023726-2fduzqyb 583 14 the the DT cord-023726-2fduzqyb 583 15 E1 E1 NNP cord-023726-2fduzqyb 583 16 and and CC cord-023726-2fduzqyb 583 17 E2 E2 NNP cord-023726-2fduzqyb 583 18 glycoproteins glycoprotein NNS cord-023726-2fduzqyb 583 19 of of IN cord-023726-2fduzqyb 583 20 Alphaviruses Alphaviruses NNP cord-023726-2fduzqyb 583 21 Structures structure NNS cord-023726-2fduzqyb 583 22 of of IN cord-023726-2fduzqyb 583 23 immature immature JJ cord-023726-2fduzqyb 583 24 flavivirus flavivirus JJ cord-023726-2fduzqyb 583 25 particles particle NNS cord-023726-2fduzqyb 584 1 Conformational Conformational NNP cord-023726-2fduzqyb 584 2 changes change NNS cord-023726-2fduzqyb 584 3 of of IN cord-023726-2fduzqyb 584 4 the the DT cord-023726-2fduzqyb 584 5 flavivirus flavivirus JJ cord-023726-2fduzqyb 584 6 E E NNP cord-023726-2fduzqyb 584 7 glycoprotein glycoprotein NN cord-023726-2fduzqyb 584 8 Visualization visualization NN cord-023726-2fduzqyb 584 9 of of IN cord-023726-2fduzqyb 584 10 membrane membrane NN cord-023726-2fduzqyb 584 11 protein protein NN cord-023726-2fduzqyb 584 12 domains domain NNS cord-023726-2fduzqyb 584 13 by by IN cord-023726-2fduzqyb 584 14 cryo cryo NN cord-023726-2fduzqyb 584 15 - - HYPH cord-023726-2fduzqyb 584 16 electron electron NN cord-023726-2fduzqyb 584 17 microscopy microscopy NN cord-023726-2fduzqyb 584 18 of of IN cord-023726-2fduzqyb 584 19 dengue dengue NN cord-023726-2fduzqyb 584 20 virus virus NN cord-023726-2fduzqyb 585 1 The the DT cord-023726-2fduzqyb 585 2 refined refined JJ cord-023726-2fduzqyb 585 3 crystal crystal NN cord-023726-2fduzqyb 585 4 structure structure NN cord-023726-2fduzqyb 585 5 of of IN cord-023726-2fduzqyb 585 6 hexon hexon NNP cord-023726-2fduzqyb 585 7 , , , cord-023726-2fduzqyb 585 8 the the DT cord-023726-2fduzqyb 585 9 major major JJ cord-023726-2fduzqyb 585 10 coat coat NN cord-023726-2fduzqyb 585 11 protein protein NN cord-023726-2fduzqyb 585 12 of of IN cord-023726-2fduzqyb 585 13 adenovirus adenovirus NN cord-023726-2fduzqyb 585 14 type type NN cord-023726-2fduzqyb 585 15 2 2 CD cord-023726-2fduzqyb 585 16 , , , cord-023726-2fduzqyb 585 17 at at IN cord-023726-2fduzqyb 585 18 2.9Å 2.9å NN cord-023726-2fduzqyb 585 19 resolution resolution NN cord-023726-2fduzqyb 585 20 Nucleocapsid Nucleocapsid NNP cord-023726-2fduzqyb 585 21 and and CC cord-023726-2fduzqyb 585 22 glycoprotein glycoprotein NN cord-023726-2fduzqyb 585 23 organization organization NN cord-023726-2fduzqyb 585 24 in in IN cord-023726-2fduzqyb 585 25 an an DT cord-023726-2fduzqyb 585 26 enveloped envelop VBN cord-023726-2fduzqyb 585 27 virus virus NN cord-023726-2fduzqyb 585 28 Three three CD cord-023726-2fduzqyb 585 29 - - HYPH cord-023726-2fduzqyb 585 30 dimensional dimensional JJ cord-023726-2fduzqyb 585 31 structure structure NN cord-023726-2fduzqyb 585 32 of of IN cord-023726-2fduzqyb 585 33 poliovirus poliovirus NN cord-023726-2fduzqyb 585 34 at at IN cord-023726-2fduzqyb 585 35 2.9Å 2.9Å NNP cord-023726-2fduzqyb 585 36 resolution resolution NN cord-023726-2fduzqyb 586 1 The the DT cord-023726-2fduzqyb 586 2 fusion fusion NN cord-023726-2fduzqyb 586 3 glycoprotein glycoprotein NN cord-023726-2fduzqyb 586 4 shell shell NN cord-023726-2fduzqyb 586 5 of of IN cord-023726-2fduzqyb 586 6 Semliki Semliki NNP cord-023726-2fduzqyb 586 7 Forest Forest NNP cord-023726-2fduzqyb 586 8 virus virus NN cord-023726-2fduzqyb 586 9 : : : cord-023726-2fduzqyb 586 10 an an DT cord-023726-2fduzqyb 586 11 icosahedral icosahedral JJ cord-023726-2fduzqyb 586 12 assembly assembly NN cord-023726-2fduzqyb 586 13 primed prime VBN cord-023726-2fduzqyb 586 14 for for IN cord-023726-2fduzqyb 586 15 fusogenic fusogenic JJ cord-023726-2fduzqyb 586 16 activation activation NN cord-023726-2fduzqyb 586 17 at at IN cord-023726-2fduzqyb 586 18 endosomal endosomal NNP cord-023726-2fduzqyb 587 1 pH pH NNP cord-023726-2fduzqyb 588 1 A a DT cord-023726-2fduzqyb 588 2 ligand ligand NN cord-023726-2fduzqyb 588 3 - - HYPH cord-023726-2fduzqyb 588 4 binding bind VBG cord-023726-2fduzqyb 588 5 pocket pocket NN cord-023726-2fduzqyb 588 6 in in IN cord-023726-2fduzqyb 588 7 the the DT cord-023726-2fduzqyb 588 8 dengue dengue NN cord-023726-2fduzqyb 588 9 virus virus NN cord-023726-2fduzqyb 588 10 envelope envelope NN cord-023726-2fduzqyb 588 11 glycoprotein glycoprotein NN cord-023726-2fduzqyb 588 12 X x NN cord-023726-2fduzqyb 588 13 - - NN cord-023726-2fduzqyb 588 14 ray ray NN cord-023726-2fduzqyb 588 15 crystallographic crystallographic JJ cord-023726-2fduzqyb 588 16 structure structure NN cord-023726-2fduzqyb 588 17 of of IN cord-023726-2fduzqyb 588 18 the the DT cord-023726-2fduzqyb 588 19 Norwalk Norwalk NNP cord-023726-2fduzqyb 588 20 virus virus NN cord-023726-2fduzqyb 588 21 capsid capsid NN cord-023726-2fduzqyb 588 22 Structure structure NN cord-023726-2fduzqyb 588 23 of of IN cord-023726-2fduzqyb 588 24 a a DT cord-023726-2fduzqyb 588 25 human human JJ cord-023726-2fduzqyb 588 26 common common JJ cord-023726-2fduzqyb 588 27 cold cold JJ cord-023726-2fduzqyb 588 28 virus virus NN cord-023726-2fduzqyb 588 29 and and CC cord-023726-2fduzqyb 588 30 functional functional JJ cord-023726-2fduzqyb 588 31 relationship relationship NN cord-023726-2fduzqyb 588 32 to to IN cord-023726-2fduzqyb 588 33 other other JJ cord-023726-2fduzqyb 588 34 picornaviruses picornavirus NNS cord-023726-2fduzqyb 589 1 The the DT cord-023726-2fduzqyb 589 2 structure structure NN cord-023726-2fduzqyb 589 3 of of IN cord-023726-2fduzqyb 589 4 simian simian JJ cord-023726-2fduzqyb 589 5 virus virus NN cord-023726-2fduzqyb 589 6 40 40 CD cord-023726-2fduzqyb 589 7 refined refine VBN cord-023726-2fduzqyb 589 8 at at IN cord-023726-2fduzqyb 589 9 3.1Å 3.1Å NNP cord-023726-2fduzqyb 589 10 resolution resolution NN cord-023726-2fduzqyb 590 1 The the DT cord-023726-2fduzqyb 590 2 canyon canyon NN cord-023726-2fduzqyb 590 3 hypothesis hypothesis NN cord-023726-2fduzqyb 591 1 In in IN cord-023726-2fduzqyb 591 2 a a DT cord-023726-2fduzqyb 591 3 Nutshell Nutshell NNP cord-023726-2fduzqyb 591 4 : : : cord-023726-2fduzqyb 591 5 structure structure NN cord-023726-2fduzqyb 591 6 and and CC cord-023726-2fduzqyb 591 7 assembly assembly NN cord-023726-2fduzqyb 591 8 of of IN cord-023726-2fduzqyb 591 9 the the DT cord-023726-2fduzqyb 591 10 vaccinia vaccinia NN cord-023726-2fduzqyb 591 11 virion virion NN cord-023726-2fduzqyb 591 12 Structure Structure NNP cord-023726-2fduzqyb 591 13 of of IN cord-023726-2fduzqyb 591 14 dengue dengue NN cord-023726-2fduzqyb 591 15 virus virus NN cord-023726-2fduzqyb 591 16 : : : cord-023726-2fduzqyb 591 17 implications implication NNS cord-023726-2fduzqyb 591 18 for for IN cord-023726-2fduzqyb 591 19 flavivirus flavivirus NNP cord-023726-2fduzqyb 591 20 organization organization NN cord-023726-2fduzqyb 591 21 , , , cord-023726-2fduzqyb 591 22 maturation maturation NN cord-023726-2fduzqyb 591 23 , , , cord-023726-2fduzqyb 591 24 and and CC cord-023726-2fduzqyb 591 25 fusion fusion VB cord-023726-2fduzqyb 591 26 A a DT cord-023726-2fduzqyb 591 27 structural structural JJ cord-023726-2fduzqyb 591 28 perspective perspective NN cord-023726-2fduzqyb 591 29 of of IN cord-023726-2fduzqyb 591 30 the the DT cord-023726-2fduzqyb 591 31 Flavivirus Flavivirus NNP cord-023726-2fduzqyb 591 32 life life NN cord-023726-2fduzqyb 591 33 cycle cycle NN cord-023726-2fduzqyb 591 34 Rotavirus rotavirus NN cord-023726-2fduzqyb 591 35 proteins protein NNS cord-023726-2fduzqyb 591 36 : : : cord-023726-2fduzqyb 591 37 structure structure NN cord-023726-2fduzqyb 591 38 and and CC cord-023726-2fduzqyb 591 39 assembly assembly NN cord-023726-2fduzqyb 591 40 Bluetongue Bluetongue NNP cord-023726-2fduzqyb 591 41 virus virus NN cord-023726-2fduzqyb 591 42 assembly assembly NN cord-023726-2fduzqyb 591 43 and and CC cord-023726-2fduzqyb 591 44 morphogenesis morphogenesis NN cord-023726-2fduzqyb 591 45 Budding budding NN cord-023726-2fduzqyb 591 46 of of IN cord-023726-2fduzqyb 591 47 alphaviruses alphaviruses NNP