id sid tid token lemma pos cord-002490-kw8psrmz 1 1 key key JJ cord-002490-kw8psrmz 1 2 : : : cord-002490-kw8psrmz 1 3 cord-002490-kw8psrmz cord-002490-kw8psrmz NN cord-002490-kw8psrmz 1 4 authors author NNS cord-002490-kw8psrmz 1 5 : : : cord-002490-kw8psrmz 1 6 Beniac Beniac NNP cord-002490-kw8psrmz 1 7 , , , cord-002490-kw8psrmz 1 8 Daniel Daniel NNP cord-002490-kw8psrmz 1 9 R. R. NNP cord-002490-kw8psrmz 1 10 ; ; : cord-002490-kw8psrmz 1 11 Booth Booth NNP cord-002490-kw8psrmz 1 12 , , , cord-002490-kw8psrmz 1 13 Timothy Timothy NNP cord-002490-kw8psrmz 1 14 F. F. NNP cord-002490-kw8psrmz 1 15 title title NN cord-002490-kw8psrmz 1 16 : : : cord-002490-kw8psrmz 1 17 Structure structure NN cord-002490-kw8psrmz 1 18 of of IN cord-002490-kw8psrmz 1 19 the the DT cord-002490-kw8psrmz 1 20 Ebola Ebola NNP cord-002490-kw8psrmz 1 21 virus virus NN cord-002490-kw8psrmz 1 22 glycoprotein glycoprotein NN cord-002490-kw8psrmz 1 23 spike spike NN cord-002490-kw8psrmz 1 24 within within IN cord-002490-kw8psrmz 1 25 the the DT cord-002490-kw8psrmz 1 26 virion virion NN cord-002490-kw8psrmz 1 27 envelope envelope NN cord-002490-kw8psrmz 1 28 at at IN cord-002490-kw8psrmz 1 29 11 11 CD cord-002490-kw8psrmz 1 30 Å å NN cord-002490-kw8psrmz 1 31 resolution resolution NN cord-002490-kw8psrmz 1 32 date date NN cord-002490-kw8psrmz 1 33 : : : cord-002490-kw8psrmz 1 34 2017 2017 CD cord-002490-kw8psrmz 1 35 - - HYPH cord-002490-kw8psrmz 1 36 04 04 CD cord-002490-kw8psrmz 1 37 - - HYPH cord-002490-kw8psrmz 1 38 11 11 CD cord-002490-kw8psrmz 1 39 journal journal NN cord-002490-kw8psrmz 1 40 : : : cord-002490-kw8psrmz 2 1 Sci Sci NNP cord-002490-kw8psrmz 2 2 Rep Rep NNP cord-002490-kw8psrmz 2 3 DOI DOI NNP cord-002490-kw8psrmz 2 4 : : : cord-002490-kw8psrmz 3 1 10.1038 10.1038 CD cord-002490-kw8psrmz 3 2 / / SYM cord-002490-kw8psrmz 3 3 srep46374 srep46374 NNP cord-002490-kw8psrmz 3 4 sha sha NNP cord-002490-kw8psrmz 3 5 : : : cord-002490-kw8psrmz 4 1 d249845a31b0c4dac3b85502b7c8f9a3af5f0f31 d249845a31b0c4dac3b85502b7c8f9a3af5f0f31 NNP cord-002490-kw8psrmz 4 2 doc_id doc_id CD cord-002490-kw8psrmz 4 3 : : : cord-002490-kw8psrmz 4 4 2490 2490 CD cord-002490-kw8psrmz 4 5 cord_uid cord_uid NN cord-002490-kw8psrmz 4 6 : : : cord-002490-kw8psrmz 5 1 kw8psrmz kw8psrmz NNP cord-002490-kw8psrmz 6 1 We -PRON- PRP cord-002490-kw8psrmz 6 2 present present VBP cord-002490-kw8psrmz 6 3 the the DT cord-002490-kw8psrmz 6 4 structure structure NN cord-002490-kw8psrmz 6 5 of of IN cord-002490-kw8psrmz 6 6 the the DT cord-002490-kw8psrmz 6 7 surface surface NN cord-002490-kw8psrmz 6 8 Ebola Ebola NNP cord-002490-kw8psrmz 6 9 virus virus NN cord-002490-kw8psrmz 6 10 ( ( -LRB- cord-002490-kw8psrmz 6 11 EBOV EBOV NNP cord-002490-kw8psrmz 6 12 ) ) -RRB- cord-002490-kw8psrmz 6 13 trimeric trimeric NNP cord-002490-kw8psrmz 6 14 glycoprotein glycoprotein NN cord-002490-kw8psrmz 6 15 ( ( -LRB- cord-002490-kw8psrmz 6 16 GP gp NN cord-002490-kw8psrmz 6 17 ) ) -RRB- cord-002490-kw8psrmz 6 18 spike spike NN cord-002490-kw8psrmz 6 19 at at IN cord-002490-kw8psrmz 6 20 11 11 CD cord-002490-kw8psrmz 6 21 Å å NN cord-002490-kw8psrmz 6 22 resolution resolution NN cord-002490-kw8psrmz 6 23 , , , cord-002490-kw8psrmz 6 24 in in IN cord-002490-kw8psrmz 6 25 situ situ NN cord-002490-kw8psrmz 6 26 within within IN cord-002490-kw8psrmz 6 27 the the DT cord-002490-kw8psrmz 6 28 viral viral JJ cord-002490-kw8psrmz 6 29 plasma plasma NN cord-002490-kw8psrmz 6 30 membrane membrane NN cord-002490-kw8psrmz 6 31 of of IN cord-002490-kw8psrmz 6 32 purified purify VBN cord-002490-kw8psrmz 6 33 virus virus NN cord-002490-kw8psrmz 6 34 particles particle NNS cord-002490-kw8psrmz 6 35 . . . cord-002490-kw8psrmz 7 1 GP GP NNP cord-002490-kw8psrmz 7 2 functions function NNS cord-002490-kw8psrmz 7 3 in in IN cord-002490-kw8psrmz 7 4 cellular cellular JJ cord-002490-kw8psrmz 7 5 attachment attachment NN cord-002490-kw8psrmz 7 6 , , , cord-002490-kw8psrmz 7 7 endosomal endosomal NNP cord-002490-kw8psrmz 7 8 entry entry NN cord-002490-kw8psrmz 7 9 , , , cord-002490-kw8psrmz 7 10 and and CC cord-002490-kw8psrmz 7 11 membrane membrane NN cord-002490-kw8psrmz 7 12 fusion fusion NN cord-002490-kw8psrmz 7 13 to to TO cord-002490-kw8psrmz 7 14 initiate initiate VB cord-002490-kw8psrmz 7 15 infection infection NN cord-002490-kw8psrmz 7 16 , , , cord-002490-kw8psrmz 7 17 and and CC cord-002490-kw8psrmz 7 18 is be VBZ cord-002490-kw8psrmz 7 19 a a DT cord-002490-kw8psrmz 7 20 key key JJ cord-002490-kw8psrmz 7 21 therapeutic therapeutic JJ cord-002490-kw8psrmz 7 22 target target NN cord-002490-kw8psrmz 7 23 . . . cord-002490-kw8psrmz 8 1 Nevertheless nevertheless RB cord-002490-kw8psrmz 8 2 , , , cord-002490-kw8psrmz 8 3 only only RB cord-002490-kw8psrmz 8 4 about about IN cord-002490-kw8psrmz 8 5 half half NN cord-002490-kw8psrmz 8 6 of of IN cord-002490-kw8psrmz 8 7 the the DT cord-002490-kw8psrmz 8 8 GP GP NNP cord-002490-kw8psrmz 8 9 molecule molecule NN cord-002490-kw8psrmz 8 10 has have VBZ cord-002490-kw8psrmz 8 11 yet yet RB cord-002490-kw8psrmz 8 12 been be VBN cord-002490-kw8psrmz 8 13 solved solve VBN cord-002490-kw8psrmz 8 14 to to IN cord-002490-kw8psrmz 8 15 atomic atomic JJ cord-002490-kw8psrmz 8 16 resolution resolution NN cord-002490-kw8psrmz 8 17 , , , cord-002490-kw8psrmz 8 18 excluding exclude VBG cord-002490-kw8psrmz 8 19 the the DT cord-002490-kw8psrmz 8 20 mucin mucin NN cord-002490-kw8psrmz 8 21 - - HYPH cord-002490-kw8psrmz 8 22 like like JJ cord-002490-kw8psrmz 8 23 and and CC cord-002490-kw8psrmz 8 24 transmembrane transmembrane NN cord-002490-kw8psrmz 8 25 domains domain NNS cord-002490-kw8psrmz 8 26 , , , cord-002490-kw8psrmz 8 27 and and CC cord-002490-kw8psrmz 8 28 some some DT cord-002490-kw8psrmz 8 29 of of IN cord-002490-kw8psrmz 8 30 the the DT cord-002490-kw8psrmz 8 31 glycans glycan NNS cord-002490-kw8psrmz 8 32 . . . cord-002490-kw8psrmz 9 1 Fitting fitting NN cord-002490-kw8psrmz 9 2 of of IN cord-002490-kw8psrmz 9 3 the the DT cord-002490-kw8psrmz 9 4 atomic atomic JJ cord-002490-kw8psrmz 9 5 resolution resolution NN cord-002490-kw8psrmz 9 6 X x NN cord-002490-kw8psrmz 9 7 - - NN cord-002490-kw8psrmz 9 8 ray ray NN cord-002490-kw8psrmz 9 9 data datum NNS cord-002490-kw8psrmz 9 10 from from IN cord-002490-kw8psrmz 9 11 expressed express VBN cord-002490-kw8psrmz 9 12 , , , cord-002490-kw8psrmz 9 13 truncated truncated JJ cord-002490-kw8psrmz 9 14 deletion deletion NN cord-002490-kw8psrmz 9 15 constructs construct NNS cord-002490-kw8psrmz 9 16 within within IN cord-002490-kw8psrmz 9 17 our -PRON- PRP$ cord-002490-kw8psrmz 9 18 11 11 CD cord-002490-kw8psrmz 9 19 Å å NN cord-002490-kw8psrmz 9 20 structure structure NN cord-002490-kw8psrmz 9 21 of of IN cord-002490-kw8psrmz 9 22 the the DT cord-002490-kw8psrmz 9 23 entire entire JJ cord-002490-kw8psrmz 9 24 molecule molecule NN cord-002490-kw8psrmz 9 25 demonstrates demonstrate VBZ cord-002490-kw8psrmz 9 26 the the DT cord-002490-kw8psrmz 9 27 relationship relationship NN cord-002490-kw8psrmz 9 28 between between IN cord-002490-kw8psrmz 9 29 the the DT cord-002490-kw8psrmz 9 30 GP1-GP2 GP1-GP2 NNP cord-002490-kw8psrmz 9 31 domains domain NNS cord-002490-kw8psrmz 9 32 , , , cord-002490-kw8psrmz 9 33 the the DT cord-002490-kw8psrmz 9 34 mucin mucin NN cord-002490-kw8psrmz 9 35 - - HYPH cord-002490-kw8psrmz 9 36 like like JJ cord-002490-kw8psrmz 9 37 and and CC cord-002490-kw8psrmz 9 38 transmembrane transmembrane NN cord-002490-kw8psrmz 9 39 domains domain NNS cord-002490-kw8psrmz 9 40 , , , cord-002490-kw8psrmz 9 41 and and CC cord-002490-kw8psrmz 9 42 the the DT cord-002490-kw8psrmz 9 43 bilaminar bilaminar NNP cord-002490-kw8psrmz 9 44 lipid lipid NN cord-002490-kw8psrmz 9 45 envelope envelope NN cord-002490-kw8psrmz 9 46 . . . cord-002490-kw8psrmz 10 1 We -PRON- PRP cord-002490-kw8psrmz 10 2 show show VBP cord-002490-kw8psrmz 10 3 that that IN cord-002490-kw8psrmz 10 4 the the DT cord-002490-kw8psrmz 10 5 mucin mucin NN cord-002490-kw8psrmz 10 6 - - HYPH cord-002490-kw8psrmz 10 7 like like JJ cord-002490-kw8psrmz 10 8 domain domain NN cord-002490-kw8psrmz 10 9 covers cover VBZ cord-002490-kw8psrmz 10 10 the the DT cord-002490-kw8psrmz 10 11 glycan glycan NN cord-002490-kw8psrmz 10 12 cap cap NN cord-002490-kw8psrmz 10 13 and and CC cord-002490-kw8psrmz 10 14 partially partially RB cord-002490-kw8psrmz 10 15 occludes occlude VBZ cord-002490-kw8psrmz 10 16 the the DT cord-002490-kw8psrmz 10 17 receptor receptor NN cord-002490-kw8psrmz 10 18 binding bind VBG cord-002490-kw8psrmz 10 19 sites site NNS cord-002490-kw8psrmz 10 20 prior prior RB cord-002490-kw8psrmz 10 21 to to IN cord-002490-kw8psrmz 10 22 proteolytic proteolytic JJ cord-002490-kw8psrmz 10 23 cleavage cleavage NN cord-002490-kw8psrmz 10 24 . . . cord-002490-kw8psrmz 11 1 Our -PRON- PRP$ cord-002490-kw8psrmz 11 2 structure structure NN cord-002490-kw8psrmz 11 3 is be VBZ cord-002490-kw8psrmz 11 4 also also RB cord-002490-kw8psrmz 11 5 consistent consistent JJ cord-002490-kw8psrmz 11 6 with with IN cord-002490-kw8psrmz 11 7 key key JJ cord-002490-kw8psrmz 11 8 antibody antibody NN cord-002490-kw8psrmz 11 9 neutralisation neutralisation NN cord-002490-kw8psrmz 11 10 sites site NNS cord-002490-kw8psrmz 11 11 on on IN cord-002490-kw8psrmz 11 12 GP GP NNP cord-002490-kw8psrmz 11 13 being be VBG cord-002490-kw8psrmz 11 14 accessible accessible JJ cord-002490-kw8psrmz 11 15 prior prior RB cord-002490-kw8psrmz 11 16 to to IN cord-002490-kw8psrmz 11 17 proteolysis proteolysis NN cord-002490-kw8psrmz 11 18 . . . cord-002490-kw8psrmz 12 1 Based base VBN cord-002490-kw8psrmz 12 2 on on IN cord-002490-kw8psrmz 12 3 the the DT cord-002490-kw8psrmz 12 4 findings finding NNS cord-002490-kw8psrmz 12 5 of of IN cord-002490-kw8psrmz 12 6 us -PRON- PRP cord-002490-kw8psrmz 12 7 and and CC cord-002490-kw8psrmz 12 8 others other NNS cord-002490-kw8psrmz 12 9 , , , cord-002490-kw8psrmz 12 10 GP gp NN cord-002490-kw8psrmz 12 11 - - HYPH cord-002490-kw8psrmz 12 12 mediated mediate VBN cord-002490-kw8psrmz 12 13 binding binding NN cord-002490-kw8psrmz 12 14 may may MD cord-002490-kw8psrmz 12 15 create create VB cord-002490-kw8psrmz 12 16 an an DT cord-002490-kw8psrmz 12 17 angle angle NN cord-002490-kw8psrmz 12 18 of of IN cord-002490-kw8psrmz 12 19 18 18 CD cord-002490-kw8psrmz 12 20 degrees degree NNS cord-002490-kw8psrmz 12 21 between between IN cord-002490-kw8psrmz 12 22 the the DT cord-002490-kw8psrmz 12 23 planes plane NNS cord-002490-kw8psrmz 12 24 of of IN cord-002490-kw8psrmz 12 25 viral viral JJ cord-002490-kw8psrmz 12 26 and and CC cord-002490-kw8psrmz 12 27 endosomal endosomal JJ cord-002490-kw8psrmz 12 28 membranes membrane NNS cord-002490-kw8psrmz 12 29 . . . cord-002490-kw8psrmz 13 1 truncated truncated JJ cord-002490-kw8psrmz 13 2 mutants mutant NNS cord-002490-kw8psrmz 13 3 without without IN cord-002490-kw8psrmz 13 4 a a DT cord-002490-kw8psrmz 13 5 transmembrane transmembrane NN cord-002490-kw8psrmz 13 6 domain domain NN cord-002490-kw8psrmz 13 7 , , , cord-002490-kw8psrmz 13 8 or or CC cord-002490-kw8psrmz 13 9 as as IN cord-002490-kw8psrmz 13 10 smaller small JJR cord-002490-kw8psrmz 13 11 sub sub NN cord-002490-kw8psrmz 13 12 - - NNS cord-002490-kw8psrmz 13 13 domains domain NNS cord-002490-kw8psrmz 13 14 of of IN cord-002490-kw8psrmz 13 15 the the DT cord-002490-kw8psrmz 13 16 GP GP NNP cord-002490-kw8psrmz 13 17 molecule molecule NN cord-002490-kw8psrmz 13 18 , , , cord-002490-kw8psrmz 13 19 or or CC cord-002490-kw8psrmz 13 20 as as IN cord-002490-kw8psrmz 13 21 artificial artificial JJ cord-002490-kw8psrmz 13 22 virus virus NN cord-002490-kw8psrmz 13 23 - - HYPH cord-002490-kw8psrmz 13 24 like like JJ cord-002490-kw8psrmz 13 25 particles particle NNS cord-002490-kw8psrmz 13 26 ( ( -LRB- cord-002490-kw8psrmz 13 27 VLPs vlp NNS cord-002490-kw8psrmz 13 28 ) ) -RRB- cord-002490-kw8psrmz 13 29 15 15 CD cord-002490-kw8psrmz 13 30 , , , cord-002490-kw8psrmz 13 31 16 16 CD cord-002490-kw8psrmz 13 32 , , , cord-002490-kw8psrmz 13 33 18 18 CD cord-002490-kw8psrmz 13 34 , , , cord-002490-kw8psrmz 13 35 24 24 CD cord-002490-kw8psrmz 13 36 , , , cord-002490-kw8psrmz 13 37 [ [ -LRB- cord-002490-kw8psrmz 13 38 26 26 CD cord-002490-kw8psrmz 13 39 ] ] -RRB- cord-002490-kw8psrmz 13 40 [ [ -LRB- cord-002490-kw8psrmz 13 41 27 27 CD cord-002490-kw8psrmz 13 42 ] ] -RRB- cord-002490-kw8psrmz 13 43 [ [ -LRB- cord-002490-kw8psrmz 13 44 28 28 CD cord-002490-kw8psrmz 13 45 ] ] -RRB- cord-002490-kw8psrmz 13 46 [ [ -LRB- cord-002490-kw8psrmz 13 47 29 29 CD cord-002490-kw8psrmz 13 48 ] ] -RRB- cord-002490-kw8psrmz 13 49 . . . cord-002490-kw8psrmz 14 1 The the DT cord-002490-kw8psrmz 14 2 structure structure NN cord-002490-kw8psrmz 14 3 presented present VBN cord-002490-kw8psrmz 14 4 in in IN cord-002490-kw8psrmz 14 5 the the DT cord-002490-kw8psrmz 14 6 current current JJ cord-002490-kw8psrmz 14 7 investigation investigation NN cord-002490-kw8psrmz 14 8 is be VBZ cord-002490-kw8psrmz 14 9 based base VBN cord-002490-kw8psrmz 14 10 solely solely RB cord-002490-kw8psrmz 14 11 on on IN cord-002490-kw8psrmz 14 12 data datum NNS cord-002490-kw8psrmz 14 13 from from IN cord-002490-kw8psrmz 14 14 the the DT cord-002490-kw8psrmz 14 15 entire entire JJ cord-002490-kw8psrmz 14 16 glycosylated glycosylated JJ cord-002490-kw8psrmz 14 17 GP gp NN cord-002490-kw8psrmz 14 18 on on IN cord-002490-kw8psrmz 14 19 the the DT cord-002490-kw8psrmz 14 20 surface surface NN cord-002490-kw8psrmz 14 21 of of IN cord-002490-kw8psrmz 14 22 EBOV EBOV NNP cord-002490-kw8psrmz 14 23 , , , cord-002490-kw8psrmz 14 24 using use VBG cord-002490-kw8psrmz 14 25 virions virion NNS cord-002490-kw8psrmz 14 26 purified purify VBN cord-002490-kw8psrmz 14 27 from from IN cord-002490-kw8psrmz 14 28 EBOV EBOV NNP cord-002490-kw8psrmz 14 29 infection infection NN cord-002490-kw8psrmz 14 30 in in IN cord-002490-kw8psrmz 14 31 cell cell NN cord-002490-kw8psrmz 14 32 culture culture NN cord-002490-kw8psrmz 14 33 , , , cord-002490-kw8psrmz 14 34 and and CC cord-002490-kw8psrmz 14 35 not not RB cord-002490-kw8psrmz 14 36 recombinant recombinant JJ cord-002490-kw8psrmz 14 37 expressed express VBN cord-002490-kw8psrmz 14 38 versions version NNS cord-002490-kw8psrmz 14 39 of of IN cord-002490-kw8psrmz 14 40 the the DT cord-002490-kw8psrmz 14 41 GP GP NNP cord-002490-kw8psrmz 14 42 spike spike NN cord-002490-kw8psrmz 14 43 . . . cord-002490-kw8psrmz 15 1 To to TO cord-002490-kw8psrmz 15 2 establish establish VB cord-002490-kw8psrmz 15 3 a a DT cord-002490-kw8psrmz 15 4 more more RBR cord-002490-kw8psrmz 15 5 definitive definitive JJ cord-002490-kw8psrmz 15 6 structure structure NN cord-002490-kw8psrmz 15 7 for for IN cord-002490-kw8psrmz 15 8 the the DT cord-002490-kw8psrmz 15 9 native native JJ cord-002490-kw8psrmz 15 10 spike spike NN cord-002490-kw8psrmz 15 11 within within IN cord-002490-kw8psrmz 15 12 the the DT cord-002490-kw8psrmz 15 13 EBOV EBOV NNP cord-002490-kw8psrmz 15 14 particle particle NN cord-002490-kw8psrmz 15 15 , , , cord-002490-kw8psrmz 15 16 we -PRON- PRP cord-002490-kw8psrmz 15 17 analysed analyse VBD cord-002490-kw8psrmz 15 18 purified purify VBN cord-002490-kw8psrmz 15 19 bona bona JJ cord-002490-kw8psrmz 15 20 - - HYPH cord-002490-kw8psrmz 15 21 fide fide JJ cord-002490-kw8psrmz 15 22 EBOV EBOV NNP cord-002490-kw8psrmz 15 23 in in IN cord-002490-kw8psrmz 15 24 order order NN cord-002490-kw8psrmz 15 25 to to TO cord-002490-kw8psrmz 15 26 image image VB cord-002490-kw8psrmz 15 27 the the DT cord-002490-kw8psrmz 15 28 GP gp NN cord-002490-kw8psrmz 15 29 spike spike NN cord-002490-kw8psrmz 15 30 within within IN cord-002490-kw8psrmz 15 31 the the DT cord-002490-kw8psrmz 15 32 virion virion NN cord-002490-kw8psrmz 15 33 envelope envelope NN cord-002490-kw8psrmz 15 34 ( ( -LRB- cord-002490-kw8psrmz 15 35 Fig Fig NNP cord-002490-kw8psrmz 15 36 . . . cord-002490-kw8psrmz 15 37 1a 1a CD cord-002490-kw8psrmz 15 38 , , , cord-002490-kw8psrmz 15 39 c c NNP cord-002490-kw8psrmz 15 40 ) ) -RRB- cord-002490-kw8psrmz 15 41 . . . cord-002490-kw8psrmz 16 1 These these DT cord-002490-kw8psrmz 16 2 GP gp NN cord-002490-kw8psrmz 16 3 spike spike NN cord-002490-kw8psrmz 16 4 images image NNS cord-002490-kw8psrmz 16 5 were be VBD cord-002490-kw8psrmz 16 6 analysed analyse VBN cord-002490-kw8psrmz 16 7 using use VBG cord-002490-kw8psrmz 16 8 the the DT cord-002490-kw8psrmz 16 9 single single JJ cord-002490-kw8psrmz 16 10 particle particle NN cord-002490-kw8psrmz 16 11 method method NN cord-002490-kw8psrmz 16 12 only only RB cord-002490-kw8psrmz 16 13 ( ( -LRB- cord-002490-kw8psrmz 16 14 Fig fig NN cord-002490-kw8psrmz 16 15 . . . cord-002490-kw8psrmz 16 16 S1,S2 S1,S2 NNP cord-002490-kw8psrmz 16 17 ) ) -RRB- cord-002490-kw8psrmz 16 18 , , , cord-002490-kw8psrmz 16 19 as as IN cord-002490-kw8psrmz 16 20 a a DT cord-002490-kw8psrmz 16 21 comparison comparison NN cord-002490-kw8psrmz 16 22 to to IN cord-002490-kw8psrmz 16 23 structures structure NNS cord-002490-kw8psrmz 16 24 previously previously RB cord-002490-kw8psrmz 16 25 obtained obtain VBN cord-002490-kw8psrmz 16 26 by by IN cord-002490-kw8psrmz 16 27 us -PRON- PRP cord-002490-kw8psrmz 16 28 and and CC cord-002490-kw8psrmz 16 29 others other NNS cord-002490-kw8psrmz 16 30 using use VBG cord-002490-kw8psrmz 16 31 tomographic tomographic JJ cord-002490-kw8psrmz 16 32 methods method NNS cord-002490-kw8psrmz 16 33 . . . cord-002490-kw8psrmz 17 1 Discrepancies discrepancy NNS cord-002490-kw8psrmz 17 2 had have VBD cord-002490-kw8psrmz 17 3 been be VBN cord-002490-kw8psrmz 17 4 observed observe VBN cord-002490-kw8psrmz 17 5 between between IN cord-002490-kw8psrmz 17 6 the the DT cord-002490-kw8psrmz 17 7 structures structure NNS cord-002490-kw8psrmz 17 8 of of IN cord-002490-kw8psrmz 17 9 the the DT cord-002490-kw8psrmz 17 10 entire entire JJ cord-002490-kw8psrmz 17 11 , , , cord-002490-kw8psrmz 17 12 untruncated untruncated JJ cord-002490-kw8psrmz 17 13 EBOV EBOV NNP cord-002490-kw8psrmz 17 14 GP GP NNP cord-002490-kw8psrmz 17 15 determined determine VBD cord-002490-kw8psrmz 17 16 using use VBG cord-002490-kw8psrmz 17 17 material material NN cord-002490-kw8psrmz 17 18 produced produce VBN cord-002490-kw8psrmz 17 19 with with IN cord-002490-kw8psrmz 17 20 differing differ VBG cord-002490-kw8psrmz 17 21 heterologous heterologous JJ cord-002490-kw8psrmz 17 22 expression expression NN cord-002490-kw8psrmz 17 23 systems system NNS cord-002490-kw8psrmz 17 24 , , , cord-002490-kw8psrmz 17 25 and and CC cord-002490-kw8psrmz 17 26 between between IN cord-002490-kw8psrmz 17 27 structures structure NNS cord-002490-kw8psrmz 17 28 obtained obtain VBN cord-002490-kw8psrmz 17 29 using use VBG cord-002490-kw8psrmz 17 30 alternative alternative JJ cord-002490-kw8psrmz 17 31 tomographic tomographic JJ cord-002490-kw8psrmz 17 32 or or CC cord-002490-kw8psrmz 17 33 single single JJ cord-002490-kw8psrmz 17 34 - - HYPH cord-002490-kw8psrmz 17 35 particle particle NN cord-002490-kw8psrmz 17 36 three three CD cord-002490-kw8psrmz 17 37 - - HYPH cord-002490-kw8psrmz 17 38 dimensional dimensional JJ cord-002490-kw8psrmz 17 39 image image NN cord-002490-kw8psrmz 17 40 processing processing NN cord-002490-kw8psrmz 17 41 methods method NNS cord-002490-kw8psrmz 17 42 4 4 CD cord-002490-kw8psrmz 17 43 , , , cord-002490-kw8psrmz 17 44 28 28 CD cord-002490-kw8psrmz 17 45 . . . cord-002490-kw8psrmz 18 1 Due due IN cord-002490-kw8psrmz 18 2 to to IN cord-002490-kw8psrmz 18 3 safety safety NN cord-002490-kw8psrmz 18 4 concerns concern NNS cord-002490-kw8psrmz 18 5 , , , cord-002490-kw8psrmz 18 6 the the DT cord-002490-kw8psrmz 18 7 virus virus NN cord-002490-kw8psrmz 18 8 preparation preparation NN cord-002490-kw8psrmz 18 9 was be VBD cord-002490-kw8psrmz 18 10 treated treat VBN cord-002490-kw8psrmz 18 11 using use VBG cord-002490-kw8psrmz 18 12 paraformaldehyde paraformaldehyde JJ cord-002490-kw8psrmz 18 13 crosslinking crosslinking NN cord-002490-kw8psrmz 18 14 ( ( -LRB- cord-002490-kw8psrmz 18 15 after after IN cord-002490-kw8psrmz 18 16 centrifugation centrifugation NN cord-002490-kw8psrmz 18 17 ) ) -RRB- cord-002490-kw8psrmz 18 18 in in IN cord-002490-kw8psrmz 18 19 a a DT cord-002490-kw8psrmz 18 20 protocol protocol NN cord-002490-kw8psrmz 18 21 that that WDT cord-002490-kw8psrmz 18 22 has have VBZ cord-002490-kw8psrmz 18 23 previously previously RB cord-002490-kw8psrmz 18 24 been be VBN cord-002490-kw8psrmz 18 25 shown show VBN cord-002490-kw8psrmz 18 26 to to TO cord-002490-kw8psrmz 18 27 preserve preserve VB cord-002490-kw8psrmz 18 28 protein protein NN cord-002490-kw8psrmz 18 29 and and CC cord-002490-kw8psrmz 18 30 lipid lipid NN cord-002490-kw8psrmz 18 31 structures structure NNS cord-002490-kw8psrmz 18 32 4 4 CD cord-002490-kw8psrmz 18 33 , , , cord-002490-kw8psrmz 18 34 30 30 CD cord-002490-kw8psrmz 18 35 . . . cord-002490-kw8psrmz 19 1 Ebola Ebola NNP cord-002490-kw8psrmz 19 2 virions virion NNS cord-002490-kw8psrmz 19 3 are be VBP cord-002490-kw8psrmz 19 4 flexible flexible JJ cord-002490-kw8psrmz 19 5 , , , cord-002490-kw8psrmz 19 6 and and CC cord-002490-kw8psrmz 19 7 viral viral JJ cord-002490-kw8psrmz 19 8 filaments filament NNS cord-002490-kw8psrmz 19 9 are be VBP cord-002490-kw8psrmz 19 10 frequently frequently RB cord-002490-kw8psrmz 19 11 curved curved JJ cord-002490-kw8psrmz 19 12 when when WRB cord-002490-kw8psrmz 19 13 prepared prepare VBN cord-002490-kw8psrmz 19 14 in in IN cord-002490-kw8psrmz 19 15 the the DT cord-002490-kw8psrmz 19 16 frozen freeze VBN cord-002490-kw8psrmz 19 17 - - HYPH cord-002490-kw8psrmz 19 18 hydrated hydrated JJ cord-002490-kw8psrmz 19 19 state state NN cord-002490-kw8psrmz 19 20 for for IN cord-002490-kw8psrmz 19 21 cryo cryo NN cord-002490-kw8psrmz 19 22 - - HYPH cord-002490-kw8psrmz 19 23 electron electron NN cord-002490-kw8psrmz 19 24 microscopy microscopy NN cord-002490-kw8psrmz 20 1 ( ( -LRB- cord-002490-kw8psrmz 20 2 Fig Fig NNP cord-002490-kw8psrmz 20 3 . . . cord-002490-kw8psrmz 20 4 1b 1b CD cord-002490-kw8psrmz 20 5 ) ) -RRB- cord-002490-kw8psrmz 20 6 . . . cord-002490-kw8psrmz 21 1 Therefore therefore RB cord-002490-kw8psrmz 21 2 , , , cord-002490-kw8psrmz 21 3 regions region NNS cord-002490-kw8psrmz 21 4 of of IN cord-002490-kw8psrmz 21 5 virions virion NNS cord-002490-kw8psrmz 21 6 that that WDT cord-002490-kw8psrmz 21 7 were be VBD cord-002490-kw8psrmz 21 8 as as RB cord-002490-kw8psrmz 21 9 straight straight RB cord-002490-kw8psrmz 21 10 as as IN cord-002490-kw8psrmz 21 11 possible possible JJ cord-002490-kw8psrmz 21 12 were be VBD cord-002490-kw8psrmz 21 13 selected select VBN cord-002490-kw8psrmz 21 14 for for IN cord-002490-kw8psrmz 21 15 image image NN cord-002490-kw8psrmz 21 16 processing processing NN cord-002490-kw8psrmz 21 17 ( ( -LRB- cord-002490-kw8psrmz 21 18 Fig Fig NNP cord-002490-kw8psrmz 21 19 . . . cord-002490-kw8psrmz 21 20 1c 1c CD cord-002490-kw8psrmz 21 21 ) ) -RRB- cord-002490-kw8psrmz 21 22 . . . cord-002490-kw8psrmz 22 1 Our -PRON- PRP$ cord-002490-kw8psrmz 22 2 data datum NNS cord-002490-kw8psrmz 22 3 included include VBD cord-002490-kw8psrmz 22 4 32,960 32,960 CD cord-002490-kw8psrmz 22 5 individual individual JJ cord-002490-kw8psrmz 22 6 spike spike NN cord-002490-kw8psrmz 22 7 images image NNS cord-002490-kw8psrmz 22 8 for for IN cord-002490-kw8psrmz 22 9 single single JJ cord-002490-kw8psrmz 22 10 particle particle NN cord-002490-kw8psrmz 22 11 analysis analysis NN cord-002490-kw8psrmz 22 12 . . . cord-002490-kw8psrmz 23 1 In in IN cord-002490-kw8psrmz 23 2 addition addition NN cord-002490-kw8psrmz 23 3 , , , cord-002490-kw8psrmz 23 4 29,976 29,976 CD cord-002490-kw8psrmz 23 5 images image NNS cord-002490-kw8psrmz 23 6 were be VBD cord-002490-kw8psrmz 23 7 selected select VBN cord-002490-kw8psrmz 23 8 for for IN cord-002490-kw8psrmz 23 9 reference reference NN cord-002490-kw8psrmz 23 10 - - HYPH cord-002490-kw8psrmz 23 11 free free JJ cord-002490-kw8psrmz 23 12 analysis analysis NN cord-002490-kw8psrmz 23 13 of of IN cord-002490-kw8psrmz 23 14 the the DT cord-002490-kw8psrmz 23 15 half half JJ cord-002490-kw8psrmz 23 16 - - HYPH cord-002490-kw8psrmz 23 17 diameter diameter NN cord-002490-kw8psrmz 23 18 of of IN cord-002490-kw8psrmz 23 19 EBOV EBOV NNP cord-002490-kw8psrmz 23 20 to to TO cord-002490-kw8psrmz 23 21 investigate investigate VB cord-002490-kw8psrmz 23 22 the the DT cord-002490-kw8psrmz 23 23 spatial spatial JJ cord-002490-kw8psrmz 23 24 distribution distribution NN cord-002490-kw8psrmz 23 25 of of IN cord-002490-kw8psrmz 23 26 the the DT cord-002490-kw8psrmz 23 27 GP gp NN cord-002490-kw8psrmz 23 28 spikes spike NNS cord-002490-kw8psrmz 23 29 , , , cord-002490-kw8psrmz 23 30 as as RB cord-002490-kw8psrmz 23 31 well well RB cord-002490-kw8psrmz 23 32 as as IN cord-002490-kw8psrmz 23 33 the the DT cord-002490-kw8psrmz 23 34 periodicity periodicity NN cord-002490-kw8psrmz 23 35 and and CC cord-002490-kw8psrmz 23 36 symmetrical symmetrical JJ cord-002490-kw8psrmz 23 37 relationships relationship NNS cord-002490-kw8psrmz 23 38 between between IN cord-002490-kw8psrmz 23 39 GP gp NN cord-002490-kw8psrmz 23 40 and and CC cord-002490-kw8psrmz 23 41 the the DT cord-002490-kw8psrmz 23 42 matrix matrix NN cord-002490-kw8psrmz 23 43 protein protein NN cord-002490-kw8psrmz 23 44 VP40 VP40 NNP cord-002490-kw8psrmz 23 45 in in IN cord-002490-kw8psrmz 23 46 the the DT cord-002490-kw8psrmz 23 47 envelope envelope NN cord-002490-kw8psrmz 23 48 , , , cord-002490-kw8psrmz 23 49 and and CC cord-002490-kw8psrmz 23 50 the the DT cord-002490-kw8psrmz 23 51 underlying underlie VBG cord-002490-kw8psrmz 23 52 nucleocapsid nucleocapsid NN cord-002490-kw8psrmz 23 53 layer layer NN cord-002490-kw8psrmz 23 54 ( ( -LRB- cord-002490-kw8psrmz 23 55 Figs Figs NNP cord-002490-kw8psrmz 23 56 1c 1c NN cord-002490-kw8psrmz 23 57 and and CC cord-002490-kw8psrmz 23 58 S3 S3 NNP cord-002490-kw8psrmz 23 59 ) ) -RRB- cord-002490-kw8psrmz 23 60 . . . cord-002490-kw8psrmz 24 1 A a DT cord-002490-kw8psrmz 24 2 3-D 3-d JJ cord-002490-kw8psrmz 24 3 structure structure NN cord-002490-kw8psrmz 24 4 for for IN cord-002490-kw8psrmz 24 5 the the DT cord-002490-kw8psrmz 24 6 GP gp NN cord-002490-kw8psrmz 24 7 spike spike NN cord-002490-kw8psrmz 24 8 trimer trimer NN cord-002490-kw8psrmz 24 9 in in IN cord-002490-kw8psrmz 24 10 situ situ NN cord-002490-kw8psrmz 24 11 , , , cord-002490-kw8psrmz 24 12 within within IN cord-002490-kw8psrmz 24 13 the the DT cord-002490-kw8psrmz 24 14 viral viral JJ cord-002490-kw8psrmz 24 15 envelope envelope NN cord-002490-kw8psrmz 24 16 , , , cord-002490-kw8psrmz 24 17 with with IN cord-002490-kw8psrmz 24 18 a a DT cord-002490-kw8psrmz 24 19 resolution resolution NN cord-002490-kw8psrmz 24 20 of of IN cord-002490-kw8psrmz 24 21 11 11 CD cord-002490-kw8psrmz 24 22 Å å NN cord-002490-kw8psrmz 24 23 was be VBD cord-002490-kw8psrmz 24 24 calculated calculate VBN cord-002490-kw8psrmz 24 25 ( ( -LRB- cord-002490-kw8psrmz 24 26 Figs Figs NNP cord-002490-kw8psrmz 24 27 2 2 CD cord-002490-kw8psrmz 24 28 and and CC cord-002490-kw8psrmz 24 29 3 3 CD cord-002490-kw8psrmz 24 30 , , , cord-002490-kw8psrmz 24 31 Supplementary Supplementary NNP cord-002490-kw8psrmz 24 32 Fig Fig NNP cord-002490-kw8psrmz 24 33 . . . cord-002490-kw8psrmz 24 34 S4 S4 NNP cord-002490-kw8psrmz 24 35 ) ) -RRB- cord-002490-kw8psrmz 24 36 using use VBG cord-002490-kw8psrmz 24 37 the the DT cord-002490-kw8psrmz 24 38 projection projection NN cord-002490-kw8psrmz 24 39 - - HYPH cord-002490-kw8psrmz 24 40 matching match VBG cord-002490-kw8psrmz 24 41 procedure procedure NN cord-002490-kw8psrmz 24 42 on on IN cord-002490-kw8psrmz 24 43 masked masked JJ cord-002490-kw8psrmz 24 44 images image NNS cord-002490-kw8psrmz 24 45 31 31 CD cord-002490-kw8psrmz 24 46 , , , cord-002490-kw8psrmz 24 47 32 32 CD cord-002490-kw8psrmz 24 48 . . . cord-002490-kw8psrmz 25 1 We -PRON- PRP cord-002490-kw8psrmz 25 2 were be VBD cord-002490-kw8psrmz 25 3 able able JJ cord-002490-kw8psrmz 25 4 to to TO cord-002490-kw8psrmz 25 5 dock dock VB cord-002490-kw8psrmz 25 6 the the DT cord-002490-kw8psrmz 25 7 atomic atomic JJ cord-002490-kw8psrmz 25 8 structure structure NN cord-002490-kw8psrmz 25 9 of of IN cord-002490-kw8psrmz 25 10 the the DT cord-002490-kw8psrmz 25 11 EBOV EBOV NNP cord-002490-kw8psrmz 25 12 GP GP NNP cord-002490-kw8psrmz 25 13 ( ( -LRB- cord-002490-kw8psrmz 25 14 5JQ7 5jq7 CD cord-002490-kw8psrmz 25 15 ) ) -RRB- cord-002490-kw8psrmz 25 16 containing contain VBG cord-002490-kw8psrmz 25 17 the the DT cord-002490-kw8psrmz 25 18 full full JJ cord-002490-kw8psrmz 25 19 - - HYPH cord-002490-kw8psrmz 25 20 length length NN cord-002490-kw8psrmz 25 21 GP1 gp1 NN cord-002490-kw8psrmz 25 22 and and CC cord-002490-kw8psrmz 25 23 GP2 GP2 NNP cord-002490-kw8psrmz 25 24 domains domain NNS cord-002490-kw8psrmz 25 25 , , , cord-002490-kw8psrmz 25 26 but but CC cord-002490-kw8psrmz 25 27 with with IN cord-002490-kw8psrmz 25 28 the the DT cord-002490-kw8psrmz 25 29 mucin mucin NN cord-002490-kw8psrmz 25 30 - - HYPH cord-002490-kw8psrmz 25 31 like like JJ cord-002490-kw8psrmz 25 32 domains domain NNS cord-002490-kw8psrmz 25 33 truncated truncate VBN cord-002490-kw8psrmz 25 34 ( ( -LRB- cord-002490-kw8psrmz 25 35 Fig Fig NNP cord-002490-kw8psrmz 25 36 . . . cord-002490-kw8psrmz 25 37 2b 2b NNP cord-002490-kw8psrmz 25 38 ) ) -RRB- cord-002490-kw8psrmz 25 39 . . . cord-002490-kw8psrmz 26 1 This this DT cord-002490-kw8psrmz 26 2 clearly clearly RB cord-002490-kw8psrmz 26 3 demonstrates demonstrate VBZ cord-002490-kw8psrmz 26 4 a a DT cord-002490-kw8psrmz 26 5 number number NN cord-002490-kw8psrmz 26 6 of of IN cord-002490-kw8psrmz 26 7 features feature NNS cord-002490-kw8psrmz 26 8 of of IN cord-002490-kw8psrmz 26 9 the the DT cord-002490-kw8psrmz 26 10 viral viral RB cord-002490-kw8psrmz 26 11 - - HYPH cord-002490-kw8psrmz 26 12 derived derive VBN cord-002490-kw8psrmz 26 13 spike spike NN cord-002490-kw8psrmz 26 14 , , , cord-002490-kw8psrmz 26 15 including include VBG cord-002490-kw8psrmz 26 16 the the DT cord-002490-kw8psrmz 26 17 structure structure NN cord-002490-kw8psrmz 26 18 and and CC cord-002490-kw8psrmz 26 19 arrangement arrangement NN cord-002490-kw8psrmz 26 20 of of IN cord-002490-kw8psrmz 26 21 the the DT cord-002490-kw8psrmz 26 22 mucin mucin NN cord-002490-kw8psrmz 26 23 - - HYPH cord-002490-kw8psrmz 26 24 like like JJ cord-002490-kw8psrmz 26 25 domains domain NNS cord-002490-kw8psrmz 26 26 with with IN cord-002490-kw8psrmz 26 27 respect respect NN cord-002490-kw8psrmz 26 28 to to IN cord-002490-kw8psrmz 26 29 the the DT cord-002490-kw8psrmz 26 30 GP1-GP2 GP1-GP2 NNP cord-002490-kw8psrmz 26 31 structure structure NN cord-002490-kw8psrmz 26 32 . . . cord-002490-kw8psrmz 27 1 In in IN cord-002490-kw8psrmz 27 2 particular particular JJ cord-002490-kw8psrmz 27 3 , , , cord-002490-kw8psrmz 27 4 the the DT cord-002490-kw8psrmz 27 5 base base NN cord-002490-kw8psrmz 27 6 of of IN cord-002490-kw8psrmz 27 7 the the DT cord-002490-kw8psrmz 27 8 spike spike NN cord-002490-kw8psrmz 27 9 , , , cord-002490-kw8psrmz 27 10 consisting consist VBG cord-002490-kw8psrmz 27 11 of of IN cord-002490-kw8psrmz 27 12 the the DT cord-002490-kw8psrmz 27 13 GP2 GP2 NNP cord-002490-kw8psrmz 27 14 fusion fusion NN cord-002490-kw8psrmz 27 15 domains domain NNS cord-002490-kw8psrmz 27 16 with with IN cord-002490-kw8psrmz 27 17 the the DT cord-002490-kw8psrmz 27 18 heptad heptad NN cord-002490-kw8psrmz 27 19 repeat repeat NN cord-002490-kw8psrmz 27 20 motifs motif NNS cord-002490-kw8psrmz 27 21 , , , cord-002490-kw8psrmz 27 22 fits fit VBZ cord-002490-kw8psrmz 27 23 extremely extremely RB cord-002490-kw8psrmz 27 24 well well RB cord-002490-kw8psrmz 27 25 : : : cord-002490-kw8psrmz 27 26 the the DT cord-002490-kw8psrmz 27 27 atomic atomic JJ cord-002490-kw8psrmz 27 28 resolution resolution NN cord-002490-kw8psrmz 27 29 structure structure NN cord-002490-kw8psrmz 27 30 5JQ7 5jq7 CD cord-002490-kw8psrmz 27 31 fills fill VBZ cord-002490-kw8psrmz 27 32 the the DT cord-002490-kw8psrmz 27 33 volume volume NN cord-002490-kw8psrmz 27 34 of of IN cord-002490-kw8psrmz 27 35 our -PRON- PRP$ cord-002490-kw8psrmz 27 36 3-D 3-d JJ cord-002490-kw8psrmz 27 37 cryo cryo NN cord-002490-kw8psrmz 27 38 - - HYPH cord-002490-kw8psrmz 27 39 EM EM NNP cord-002490-kw8psrmz 27 40 structure structure NN cord-002490-kw8psrmz 27 41 ( ( -LRB- cord-002490-kw8psrmz 27 42 Fig Fig NNP cord-002490-kw8psrmz 27 43 . . . cord-002490-kw8psrmz 27 44 2a 2a CD cord-002490-kw8psrmz 27 45 ) ) -RRB- cord-002490-kw8psrmz 27 46 . . . cord-002490-kw8psrmz 28 1 The the DT cord-002490-kw8psrmz 28 2 closeness closeness NN cord-002490-kw8psrmz 28 3 of of IN cord-002490-kw8psrmz 28 4 fit fit NN cord-002490-kw8psrmz 28 5 , , , cord-002490-kw8psrmz 28 6 especially especially RB cord-002490-kw8psrmz 28 7 in in IN cord-002490-kw8psrmz 28 8 the the DT cord-002490-kw8psrmz 28 9 stalk stalk NN cord-002490-kw8psrmz 28 10 or or CC cord-002490-kw8psrmz 28 11 " " `` cord-002490-kw8psrmz 28 12 neck neck NN cord-002490-kw8psrmz 28 13 " " '' cord-002490-kw8psrmz 28 14 area area NN cord-002490-kw8psrmz 28 15 of of IN cord-002490-kw8psrmz 28 16 the the DT cord-002490-kw8psrmz 28 17 GP GP NNP cord-002490-kw8psrmz 28 18 trimer trimer NN cord-002490-kw8psrmz 28 19 , , , cord-002490-kw8psrmz 28 20 is be VBZ cord-002490-kw8psrmz 28 21 apparent apparent JJ cord-002490-kw8psrmz 28 22 when when WRB cord-002490-kw8psrmz 28 23 the the DT cord-002490-kw8psrmz 28 24 spike spike NN cord-002490-kw8psrmz 28 25 structure structure NN cord-002490-kw8psrmz 28 26 is be VBZ cord-002490-kw8psrmz 28 27 displayed display VBN cord-002490-kw8psrmz 28 28 at at IN cord-002490-kw8psrmz 28 29 a a DT cord-002490-kw8psrmz 28 30 density density NN cord-002490-kw8psrmz 28 31 where where WRB cord-002490-kw8psrmz 28 32 the the DT cord-002490-kw8psrmz 28 33 5 5 CD cord-002490-kw8psrmz 28 34 nm nm NN cord-002490-kw8psrmz 28 35 thick thick JJ cord-002490-kw8psrmz 28 36 bilayer bilayer NN cord-002490-kw8psrmz 28 37 nature nature NN cord-002490-kw8psrmz 28 38 of of IN cord-002490-kw8psrmz 28 39 the the DT cord-002490-kw8psrmz 28 40 virion virion NN cord-002490-kw8psrmz 28 41 envelope envelope NN cord-002490-kw8psrmz 28 42 is be VBZ cord-002490-kw8psrmz 28 43 clearly clearly RB cord-002490-kw8psrmz 28 44 visible visible JJ cord-002490-kw8psrmz 28 45 ( ( -LRB- cord-002490-kw8psrmz 28 46 Figs Figs NNP cord-002490-kw8psrmz 28 47 2a 2a CD cord-002490-kw8psrmz 28 48 , , , cord-002490-kw8psrmz 28 49 c c NN cord-002490-kw8psrmz 28 50 and and CC cord-002490-kw8psrmz 28 51 3a 3a NNP cord-002490-kw8psrmz 28 52 ) ) -RRB- cord-002490-kw8psrmz 28 53 and and CC cord-002490-kw8psrmz 28 54 also also RB cord-002490-kw8psrmz 28 55 when when WRB cord-002490-kw8psrmz 28 56 the the DT cord-002490-kw8psrmz 28 57 surface surface NN cord-002490-kw8psrmz 28 58 is be VBZ cord-002490-kw8psrmz 28 59 truncated truncate VBN cord-002490-kw8psrmz 28 60 to to IN cord-002490-kw8psrmz 28 61 a a DT cord-002490-kw8psrmz 28 62 level level NN cord-002490-kw8psrmz 28 63 where where WRB cord-002490-kw8psrmz 28 64 the the DT cord-002490-kw8psrmz 28 65 volume volume NN cord-002490-kw8psrmz 28 66 approximates approximate VBZ cord-002490-kw8psrmz 28 67 to to IN cord-002490-kw8psrmz 28 68 a a DT cord-002490-kw8psrmz 28 69 molecular molecular JJ cord-002490-kw8psrmz 28 70 weight weight NN cord-002490-kw8psrmz 28 71 of of IN cord-002490-kw8psrmz 28 72 310 310 CD cord-002490-kw8psrmz 28 73 kDa kDa NNS cord-002490-kw8psrmz 28 74 ( ( -LRB- cord-002490-kw8psrmz 28 75 Figs Figs NNP cord-002490-kw8psrmz 28 76 2 2 CD cord-002490-kw8psrmz 28 77 and and CC cord-002490-kw8psrmz 28 78 3b 3b CD cord-002490-kw8psrmz 28 79 ) ) -RRB- cord-002490-kw8psrmz 28 80 . . . cord-002490-kw8psrmz 29 1 The the DT cord-002490-kw8psrmz 29 2 alpha alpha NN cord-002490-kw8psrmz 29 3 - - HYPH cord-002490-kw8psrmz 29 4 helices helix NNS cord-002490-kw8psrmz 29 5 of of IN cord-002490-kw8psrmz 29 6 GP2 GP2 NNP cord-002490-kw8psrmz 29 7 are be VBP cord-002490-kw8psrmz 29 8 visible visible JJ cord-002490-kw8psrmz 29 9 at at IN cord-002490-kw8psrmz 29 10 the the DT cord-002490-kw8psrmz 29 11 base base NN cord-002490-kw8psrmz 29 12 of of IN cord-002490-kw8psrmz 29 13 the the DT cord-002490-kw8psrmz 29 14 spike spike NN cord-002490-kw8psrmz 29 15 , , , cord-002490-kw8psrmz 29 16 ( ( -LRB- cord-002490-kw8psrmz 30 1 Fig Fig NNP cord-002490-kw8psrmz 30 2 . . NNP cord-002490-kw8psrmz 30 3 2a 2a CD cord-002490-kw8psrmz 30 4 ) ) -RRB- cord-002490-kw8psrmz 30 5 and and CC cord-002490-kw8psrmz 30 6 when when WRB cord-002490-kw8psrmz 30 7 the the DT cord-002490-kw8psrmz 30 8 reconstruction reconstruction NN cord-002490-kw8psrmz 30 9 is be VBZ cord-002490-kw8psrmz 30 10 displayed display VBN cord-002490-kw8psrmz 30 11 at at IN cord-002490-kw8psrmz 30 12 a a DT cord-002490-kw8psrmz 30 13 slightly slightly RB cord-002490-kw8psrmz 30 14 higher high JJR cord-002490-kw8psrmz 30 15 contour contour NN cord-002490-kw8psrmz 30 16 level level NN cord-002490-kw8psrmz 30 17 , , , cord-002490-kw8psrmz 30 18 densities density NNS cord-002490-kw8psrmz 30 19 that that WDT cord-002490-kw8psrmz 30 20 cross cross VBP cord-002490-kw8psrmz 30 21 the the DT cord-002490-kw8psrmz 30 22 interior interior NN cord-002490-kw8psrmz 30 23 of of IN cord-002490-kw8psrmz 30 24 the the DT cord-002490-kw8psrmz 30 25 membrane membrane NN cord-002490-kw8psrmz 30 26 are be VBP cord-002490-kw8psrmz 30 27 visible visible JJ cord-002490-kw8psrmz 30 28 ( ( -LRB- cord-002490-kw8psrmz 30 29 Fig Fig NNP cord-002490-kw8psrmz 30 30 . . . cord-002490-kw8psrmz 30 31 2c 2c NNP cord-002490-kw8psrmz 30 32 ) ) -RRB- cord-002490-kw8psrmz 30 33 . . . cord-002490-kw8psrmz 31 1 Since since IN cord-002490-kw8psrmz 31 2 the the DT cord-002490-kw8psrmz 31 3 N n CD cord-002490-kw8psrmz 31 4 - - HYPH cord-002490-kw8psrmz 31 5 terminal terminal NN cord-002490-kw8psrmz 31 6 ends end NNS cord-002490-kw8psrmz 31 7 of of IN cord-002490-kw8psrmz 31 8 the the DT cord-002490-kw8psrmz 31 9 docked dock VBN cord-002490-kw8psrmz 31 10 alpha-5 alpha-5 NNP cord-002490-kw8psrmz 31 11 GP2 GP2 NNP cord-002490-kw8psrmz 31 12 domains domain NNS cord-002490-kw8psrmz 31 13 ( ( -LRB- cord-002490-kw8psrmz 31 14 2EBO 2ebo CD cord-002490-kw8psrmz 31 15 24 24 CD cord-002490-kw8psrmz 31 16 ) ) -RRB- cord-002490-kw8psrmz 31 17 appear appear VBP cord-002490-kw8psrmz 31 18 to to TO cord-002490-kw8psrmz 31 19 line line VB cord-002490-kw8psrmz 31 20 up up RP cord-002490-kw8psrmz 31 21 with with IN cord-002490-kw8psrmz 31 22 these these DT cord-002490-kw8psrmz 31 23 transmembrane transmembrane JJ cord-002490-kw8psrmz 31 24 densities density NNS cord-002490-kw8psrmz 31 25 , , , cord-002490-kw8psrmz 31 26 the the DT cord-002490-kw8psrmz 31 27 latter latter JJ cord-002490-kw8psrmz 31 28 may may MD cord-002490-kw8psrmz 31 29 be be VB cord-002490-kw8psrmz 31 30 an an DT cord-002490-kw8psrmz 31 31 indication indication NN cord-002490-kw8psrmz 31 32 of of IN cord-002490-kw8psrmz 31 33 the the DT cord-002490-kw8psrmz 31 34 putative putative JJ cord-002490-kw8psrmz 31 35 hydrophobic hydrophobic JJ cord-002490-kw8psrmz 31 36 alpha alpha NN cord-002490-kw8psrmz 31 37 - - HYPH cord-002490-kw8psrmz 31 38 helical helical JJ cord-002490-kw8psrmz 31 39 transmembrane transmembrane NN cord-002490-kw8psrmz 31 40 regions region NNS cord-002490-kw8psrmz 31 41 of of IN cord-002490-kw8psrmz 31 42 GP2 GP2 NNP cord-002490-kw8psrmz 31 43 ( ( -LRB- cord-002490-kw8psrmz 31 44 Fig Fig NNP cord-002490-kw8psrmz 31 45 . . . cord-002490-kw8psrmz 31 46 2c 2c NNP cord-002490-kw8psrmz 31 47 ) ) -RRB- cord-002490-kw8psrmz 31 48 . . . cord-002490-kw8psrmz 32 1 Using use VBG cord-002490-kw8psrmz 32 2 the the DT cord-002490-kw8psrmz 32 3 predicted predict VBN cord-002490-kw8psrmz 32 4 mass mass NN cord-002490-kw8psrmz 32 5 of of IN cord-002490-kw8psrmz 32 6 the the DT cord-002490-kw8psrmz 32 7 GP GP NNP cord-002490-kw8psrmz 32 8 ( ( -LRB- cord-002490-kw8psrmz 32 9 as as IN cord-002490-kw8psrmz 32 10 measured measure VBN cord-002490-kw8psrmz 32 11 by by IN cord-002490-kw8psrmz 32 12 gel gel NN cord-002490-kw8psrmz 32 13 electrophoresis electrophoresis NN cord-002490-kw8psrmz 32 14 of of IN cord-002490-kw8psrmz 32 15 virion virion NN cord-002490-kw8psrmz 32 16 - - HYPH cord-002490-kw8psrmz 32 17 derived derive VBN cord-002490-kw8psrmz 32 18 GP GP NNP cord-002490-kw8psrmz 32 19 33 33 CD cord-002490-kw8psrmz 32 20 ) ) -RRB- cord-002490-kw8psrmz 32 21 we -PRON- PRP cord-002490-kw8psrmz 32 22 adjusted adjust VBD cord-002490-kw8psrmz 32 23 the the DT cord-002490-kw8psrmz 32 24 volume volume NN cord-002490-kw8psrmz 32 25 of of IN cord-002490-kw8psrmz 32 26 the the DT cord-002490-kw8psrmz 32 27 3-D 3-d JJ cord-002490-kw8psrmz 32 28 structure structure NN cord-002490-kw8psrmz 32 29 in in IN cord-002490-kw8psrmz 32 30 Fig Fig NNP cord-002490-kw8psrmz 32 31 . . NNP cord-002490-kw8psrmz 32 32 2 2 CD cord-002490-kw8psrmz 32 33 , , , cord-002490-kw8psrmz 32 34 using use VBG cord-002490-kw8psrmz 32 35 a a DT cord-002490-kw8psrmz 32 36 value value NN cord-002490-kw8psrmz 32 37 of of IN cord-002490-kw8psrmz 32 38 0.8 0.8 CD cord-002490-kw8psrmz 32 39 Da Da NNP cord-002490-kw8psrmz 32 40 / / SYM cord-002490-kw8psrmz 32 41 Å Å NNP cord-002490-kw8psrmz 32 42 3 3 CD cord-002490-kw8psrmz 32 43 as as IN cord-002490-kw8psrmz 32 44 an an DT cord-002490-kw8psrmz 32 45 approximate approximate JJ cord-002490-kw8psrmz 32 46 density density NN cord-002490-kw8psrmz 32 47 for for IN cord-002490-kw8psrmz 32 48 protein protein NN cord-002490-kw8psrmz 32 49 34 34 CD cord-002490-kw8psrmz 32 50 . . . cord-002490-kw8psrmz 33 1 Since since IN cord-002490-kw8psrmz 33 2 the the DT cord-002490-kw8psrmz 33 3 structure structure NN cord-002490-kw8psrmz 33 4 5JQ7 5jq7 CD cord-002490-kw8psrmz 33 5 is be VBZ cord-002490-kw8psrmz 33 6 163 163 CD cord-002490-kw8psrmz 33 7 kDa kDa NNP cord-002490-kw8psrmz 33 8 35 35 CD cord-002490-kw8psrmz 33 9 , , , cord-002490-kw8psrmz 33 10 the the DT cord-002490-kw8psrmz 33 11 truncated truncated JJ cord-002490-kw8psrmz 33 12 mucin mucin NN cord-002490-kw8psrmz 33 13 - - HYPH cord-002490-kw8psrmz 33 14 like like JJ cord-002490-kw8psrmz 33 15 and and CC cord-002490-kw8psrmz 33 16 transmembrane transmembrane NN cord-002490-kw8psrmz 33 17 domains domain NNS cord-002490-kw8psrmz 33 18 , , , cord-002490-kw8psrmz 33 19 including include VBG cord-002490-kw8psrmz 33 20 glycans glycan NNS cord-002490-kw8psrmz 33 21 , , , cord-002490-kw8psrmz 33 22 represent represent VBP cord-002490-kw8psrmz 33 23 ~150 ~150 WP cord-002490-kw8psrmz 33 24 - - HYPH cord-002490-kw8psrmz 33 25 170 170 CD cord-002490-kw8psrmz 33 26 kDa kDa NNS cord-002490-kw8psrmz 33 27 , , , cord-002490-kw8psrmz 33 28 approximately approximately RB cord-002490-kw8psrmz 33 29 half half PDT cord-002490-kw8psrmz 33 30 the the DT cord-002490-kw8psrmz 33 31 mass mass NN cord-002490-kw8psrmz 33 32 of of IN cord-002490-kw8psrmz 33 33 the the DT cord-002490-kw8psrmz 33 34 spike spike NN cord-002490-kw8psrmz 33 35 . . . cord-002490-kw8psrmz 34 1 When when WRB cord-002490-kw8psrmz 34 2 viewed view VBN cord-002490-kw8psrmz 34 3 from from IN cord-002490-kw8psrmz 34 4 above above RB cord-002490-kw8psrmz 34 5 , , , cord-002490-kw8psrmz 34 6 the the DT cord-002490-kw8psrmz 34 7 GP GP NNP cord-002490-kw8psrmz 34 8 spike spike NN cord-002490-kw8psrmz 34 9 looks look VBZ cord-002490-kw8psrmz 34 10 like like IN cord-002490-kw8psrmz 34 11 a a DT cord-002490-kw8psrmz 34 12 three three CD cord-002490-kw8psrmz 34 13 - - HYPH cord-002490-kw8psrmz 34 14 bladed bladed JJ cord-002490-kw8psrmz 34 15 propeller propeller NN cord-002490-kw8psrmz 34 16 ( ( -LRB- cord-002490-kw8psrmz 34 17 Figs fig NNS cord-002490-kw8psrmz 34 18 2a 2a CD cord-002490-kw8psrmz 34 19 and and CC cord-002490-kw8psrmz 34 20 3b 3b CD cord-002490-kw8psrmz 34 21 ) ) -RRB- cord-002490-kw8psrmz 34 22 . . . cord-002490-kw8psrmz 35 1 The the DT cord-002490-kw8psrmz 35 2 length length NN cord-002490-kw8psrmz 35 3 of of IN cord-002490-kw8psrmz 35 4 the the DT cord-002490-kw8psrmz 35 5 three three CD cord-002490-kw8psrmz 35 6 " " `` cord-002490-kw8psrmz 35 7 blades blade NNS cord-002490-kw8psrmz 35 8 " " '' cord-002490-kw8psrmz 35 9 encompasses encompass VBZ cord-002490-kw8psrmz 35 10 a a DT cord-002490-kw8psrmz 35 11 circle circle NN cord-002490-kw8psrmz 35 12 that that WDT cord-002490-kw8psrmz 35 13 is be VBZ cord-002490-kw8psrmz 35 14 18 18 CD cord-002490-kw8psrmz 35 15 nm nm NN cord-002490-kw8psrmz 35 16 in in IN cord-002490-kw8psrmz 35 17 diameter diameter NN cord-002490-kw8psrmz 35 18 . . . cord-002490-kw8psrmz 36 1 When when WRB cord-002490-kw8psrmz 36 2 viewed view VBN cord-002490-kw8psrmz 36 3 from from IN cord-002490-kw8psrmz 36 4 the the DT cord-002490-kw8psrmz 36 5 side side NN cord-002490-kw8psrmz 36 6 , , , cord-002490-kw8psrmz 36 7 the the DT cord-002490-kw8psrmz 36 8 GP GP NNP cord-002490-kw8psrmz 36 9 spike spike NN cord-002490-kw8psrmz 36 10 has have VBZ cord-002490-kw8psrmz 36 11 a a DT cord-002490-kw8psrmz 36 12 stalk stalk NN cord-002490-kw8psrmz 36 13 region region NN cord-002490-kw8psrmz 36 14 adjacent adjacent JJ cord-002490-kw8psrmz 36 15 to to IN cord-002490-kw8psrmz 36 16 the the DT cord-002490-kw8psrmz 36 17 viral viral JJ cord-002490-kw8psrmz 36 18 envelope envelope NN cord-002490-kw8psrmz 36 19 , , , cord-002490-kw8psrmz 36 20 which which WDT cord-002490-kw8psrmz 36 21 then then RB cord-002490-kw8psrmz 36 22 spreads spread VBZ cord-002490-kw8psrmz 36 23 out out RP cord-002490-kw8psrmz 36 24 to to IN cord-002490-kw8psrmz 36 25 the the DT cord-002490-kw8psrmz 36 26 upper upper JJ cord-002490-kw8psrmz 36 27 part part NN cord-002490-kw8psrmz 36 28 of of IN cord-002490-kw8psrmz 36 29 the the DT cord-002490-kw8psrmz 36 30 GP GP NNP cord-002490-kw8psrmz 36 31 spike spike NN cord-002490-kw8psrmz 36 32 . . . cord-002490-kw8psrmz 37 1 The the DT cord-002490-kw8psrmz 37 2 toremifene toremifene NN cord-002490-kw8psrmz 37 3 - - HYPH cord-002490-kw8psrmz 37 4 binding bind VBG cord-002490-kw8psrmz 37 5 " " `` cord-002490-kw8psrmz 37 6 pocket pocket NN cord-002490-kw8psrmz 37 7 " " '' cord-002490-kw8psrmz 37 8 or or CC cord-002490-kw8psrmz 37 9 " " `` cord-002490-kw8psrmz 37 10 tunnel tunnel NN cord-002490-kw8psrmz 37 11 " " '' cord-002490-kw8psrmz 37 12 identified identify VBN cord-002490-kw8psrmz 37 13 in in IN cord-002490-kw8psrmz 37 14 5JQ7 5jq7 CD cord-002490-kw8psrmz 37 15 is be VBZ cord-002490-kw8psrmz 37 16 near near IN cord-002490-kw8psrmz 37 17 the the DT cord-002490-kw8psrmz 37 18 surface surface NN cord-002490-kw8psrmz 37 19 of of IN cord-002490-kw8psrmz 37 20 the the DT cord-002490-kw8psrmz 37 21 3-D 3-d JJ cord-002490-kw8psrmz 37 22 EM EM NNP cord-002490-kw8psrmz 37 23 structure structure NN cord-002490-kw8psrmz 37 24 , , , cord-002490-kw8psrmz 37 25 on on IN cord-002490-kw8psrmz 37 26 the the DT cord-002490-kw8psrmz 37 27 side side NN cord-002490-kw8psrmz 37 28 of of IN cord-002490-kw8psrmz 37 29 the the DT cord-002490-kw8psrmz 37 30 stalk stalk NN cord-002490-kw8psrmz 37 31 at at IN cord-002490-kw8psrmz 37 32 the the DT cord-002490-kw8psrmz 37 33 base base NN cord-002490-kw8psrmz 37 34 of of IN cord-002490-kw8psrmz 37 35 the the DT cord-002490-kw8psrmz 37 36 propellers propeller NNS cord-002490-kw8psrmz 37 37 ( ( -LRB- cord-002490-kw8psrmz 37 38 Figs fig NNS cord-002490-kw8psrmz 37 39 2a 2a CD cord-002490-kw8psrmz 37 40 and and CC cord-002490-kw8psrmz 37 41 3b 3b CD cord-002490-kw8psrmz 37 42 ) ) -RRB- cord-002490-kw8psrmz 37 43 . . . cord-002490-kw8psrmz 38 1 At at IN cord-002490-kw8psrmz 38 2 the the DT cord-002490-kw8psrmz 38 3 base base NN cord-002490-kw8psrmz 38 4 of of IN cord-002490-kw8psrmz 38 5 the the DT cord-002490-kw8psrmz 38 6 stalk stalk NN cord-002490-kw8psrmz 38 7 in in IN cord-002490-kw8psrmz 38 8 Fig Fig NNP cord-002490-kw8psrmz 38 9 . . . cord-002490-kw8psrmz 39 1 2a 2a LS cord-002490-kw8psrmz 39 2 , , , cord-002490-kw8psrmz 39 3 the the DT cord-002490-kw8psrmz 39 4 three three CD cord-002490-kw8psrmz 39 5 heptad heptad NN cord-002490-kw8psrmz 39 6 repeat repeat NN cord-002490-kw8psrmz 39 7 helices helix NNS cord-002490-kw8psrmz 39 8 at at IN cord-002490-kw8psrmz 39 9 the the DT cord-002490-kw8psrmz 39 10 base base NN cord-002490-kw8psrmz 39 11 of of IN cord-002490-kw8psrmz 39 12 GP2 GP2 NNP cord-002490-kw8psrmz 39 13 fit fit VBD cord-002490-kw8psrmz 39 14 neatly neatly RB cord-002490-kw8psrmz 39 15 into into IN cord-002490-kw8psrmz 39 16 three three CD cord-002490-kw8psrmz 39 17 strands strand NNS cord-002490-kw8psrmz 39 18 visible visible JJ cord-002490-kw8psrmz 39 19 in in IN cord-002490-kw8psrmz 39 20 our -PRON- PRP$ cord-002490-kw8psrmz 39 21 EM em JJ cord-002490-kw8psrmz 39 22 3-D 3-d JJ cord-002490-kw8psrmz 39 23 structure structure NN cord-002490-kw8psrmz 39 24 , , , cord-002490-kw8psrmz 39 25 that that WDT cord-002490-kw8psrmz 39 26 appear appear VBP cord-002490-kw8psrmz 39 27 to to TO cord-002490-kw8psrmz 39 28 penetrate penetrate VB cord-002490-kw8psrmz 39 29 the the DT cord-002490-kw8psrmz 39 30 virion virion NN cord-002490-kw8psrmz 39 31 membrane membrane NN cord-002490-kw8psrmz 39 32 ( ( -LRB- cord-002490-kw8psrmz 39 33 Figs Figs NNP cord-002490-kw8psrmz 39 34 2a 2a CD cord-002490-kw8psrmz 39 35 and and CC cord-002490-kw8psrmz 39 36 3a 3a NN cord-002490-kw8psrmz 39 37 ) ) -RRB- cord-002490-kw8psrmz 39 38 . . . cord-002490-kw8psrmz 40 1 Also also RB cord-002490-kw8psrmz 40 2 , , , cord-002490-kw8psrmz 40 3 when when WRB cord-002490-kw8psrmz 40 4 viewed view VBN cord-002490-kw8psrmz 40 5 from from IN cord-002490-kw8psrmz 40 6 the the DT cord-002490-kw8psrmz 40 7 top top NN cord-002490-kw8psrmz 40 8 , , , cord-002490-kw8psrmz 40 9 each each DT cord-002490-kw8psrmz 40 10 blade blade NN cord-002490-kw8psrmz 40 11 has have VBZ cord-002490-kw8psrmz 40 12 a a DT cord-002490-kw8psrmz 40 13 smaller small JJR cord-002490-kw8psrmz 40 14 nub nub NN cord-002490-kw8psrmz 40 15 closer close RBR cord-002490-kw8psrmz 40 16 to to IN cord-002490-kw8psrmz 40 17 the the DT cord-002490-kw8psrmz 40 18 3-fold 3-fold CD cord-002490-kw8psrmz 40 19 axis axis NN cord-002490-kw8psrmz 40 20 that that WDT cord-002490-kw8psrmz 40 21 protrudes protrude VBZ cord-002490-kw8psrmz 40 22 distally distally RB cord-002490-kw8psrmz 40 23 ( ( -LRB- cord-002490-kw8psrmz 40 24 Figs fig NNS cord-002490-kw8psrmz 40 25 2a 2a CD cord-002490-kw8psrmz 40 26 and and CC cord-002490-kw8psrmz 40 27 3b 3b CD cord-002490-kw8psrmz 40 28 ) ) -RRB- cord-002490-kw8psrmz 40 29 . . . cord-002490-kw8psrmz 41 1 Using use VBG cord-002490-kw8psrmz 41 2 the the DT cord-002490-kw8psrmz 41 3 332 332 CD cord-002490-kw8psrmz 41 4 kDa kDa NNP cord-002490-kw8psrmz 41 5 contour contour NN cord-002490-kw8psrmz 41 6 level level NN cord-002490-kw8psrmz 41 7 , , , cord-002490-kw8psrmz 41 8 these these DT cord-002490-kw8psrmz 41 9 nubs nub NNS cord-002490-kw8psrmz 41 10 correspond correspond VBP cord-002490-kw8psrmz 41 11 closely closely RB cord-002490-kw8psrmz 41 12 with with IN cord-002490-kw8psrmz 41 13 the the DT cord-002490-kw8psrmz 41 14 receptor receptor NN cord-002490-kw8psrmz 41 15 binding binding NN cord-002490-kw8psrmz 41 16 site site NN cord-002490-kw8psrmz 41 17 , , , cord-002490-kw8psrmz 41 18 covering cover VBG cord-002490-kw8psrmz 41 19 most most JJS cord-002490-kw8psrmz 41 20 of of IN cord-002490-kw8psrmz 41 21 the the DT cord-002490-kw8psrmz 41 22 residues residue NNS cord-002490-kw8psrmz 41 23 known know VBN cord-002490-kw8psrmz 41 24 to to TO cord-002490-kw8psrmz 41 25 be be VB cord-002490-kw8psrmz 41 26 involved involve VBN cord-002490-kw8psrmz 41 27 in in IN cord-002490-kw8psrmz 41 28 binding bind VBG cord-002490-kw8psrmz 41 29 , , , cord-002490-kw8psrmz 41 30 as as RB cord-002490-kw8psrmz 41 31 well well RB cord-002490-kw8psrmz 41 32 as as IN cord-002490-kw8psrmz 41 33 protruding protrude VBG cord-002490-kw8psrmz 41 34 adjacent adjacent JJ cord-002490-kw8psrmz 41 35 to to IN cord-002490-kw8psrmz 41 36 the the DT cord-002490-kw8psrmz 41 37 glycan glycan NN cord-002490-kw8psrmz 41 38 cap cap NN cord-002490-kw8psrmz 41 39 regions region NNS cord-002490-kw8psrmz 41 40 . . . cord-002490-kw8psrmz 42 1 Each each DT cord-002490-kw8psrmz 42 2 propeller propeller NN cord-002490-kw8psrmz 42 3 blade blade NN cord-002490-kw8psrmz 42 4 , , , cord-002490-kw8psrmz 42 5 which which WDT cord-002490-kw8psrmz 42 6 is be VBZ cord-002490-kw8psrmz 42 7 known know VBN cord-002490-kw8psrmz 42 8 to to TO cord-002490-kw8psrmz 42 9 contain contain VB cord-002490-kw8psrmz 42 10 the the DT cord-002490-kw8psrmz 42 11 mucin mucin NN cord-002490-kw8psrmz 42 12 - - HYPH cord-002490-kw8psrmz 42 13 like like JJ cord-002490-kw8psrmz 42 14 domain domain NN cord-002490-kw8psrmz 42 15 28 28 CD cord-002490-kw8psrmz 42 16 , , , cord-002490-kw8psrmz 42 17 completely completely RB cord-002490-kw8psrmz 42 18 covers cover VBZ cord-002490-kw8psrmz 42 19 the the DT cord-002490-kw8psrmz 42 20 site site NN cord-002490-kw8psrmz 42 21 known know VBN cord-002490-kw8psrmz 42 22 to to TO cord-002490-kw8psrmz 42 23 bind bind VB cord-002490-kw8psrmz 42 24 to to IN cord-002490-kw8psrmz 42 25 the the DT cord-002490-kw8psrmz 42 26 NPC-1 NPC-1 NNP cord-002490-kw8psrmz 42 27 receptor receptor NN cord-002490-kw8psrmz 42 28 ( ( -LRB- cord-002490-kw8psrmz 42 29 Fig Fig NNP cord-002490-kw8psrmz 42 30 . . . cord-002490-kw8psrmz 42 31 3b 3b CD cord-002490-kw8psrmz 42 32 ) ) -RRB- cord-002490-kw8psrmz 42 33 . . . cord-002490-kw8psrmz 43 1 Thus thus RB cord-002490-kw8psrmz 43 2 approximately approximately RB cord-002490-kw8psrmz 43 3 half half NN cord-002490-kw8psrmz 43 4 of of IN cord-002490-kw8psrmz 43 5 the the DT cord-002490-kw8psrmz 43 6 mass mass NN cord-002490-kw8psrmz 43 7 in in IN cord-002490-kw8psrmz 43 8 our -PRON- PRP$ cord-002490-kw8psrmz 43 9 structure structure NN cord-002490-kw8psrmz 43 10 , , , cord-002490-kw8psrmz 43 11 external external JJ cord-002490-kw8psrmz 43 12 to to IN cord-002490-kw8psrmz 43 13 the the DT cord-002490-kw8psrmz 43 14 envelope envelope NN cord-002490-kw8psrmz 43 15 , , , cord-002490-kw8psrmz 43 16 are be VBP cord-002490-kw8psrmz 43 17 the the DT cord-002490-kw8psrmz 43 18 mucin mucin NN cord-002490-kw8psrmz 43 19 - - HYPH cord-002490-kw8psrmz 43 20 like like JJ cord-002490-kw8psrmz 43 21 domains domain NNS cord-002490-kw8psrmz 43 22 . . . cord-002490-kw8psrmz 44 1 When when WRB cord-002490-kw8psrmz 44 2 the the DT cord-002490-kw8psrmz 44 3 density density NN cord-002490-kw8psrmz 44 4 map map NN cord-002490-kw8psrmz 44 5 is be VBZ cord-002490-kw8psrmz 44 6 contoured contour VBN cord-002490-kw8psrmz 44 7 to to IN cord-002490-kw8psrmz 44 8 a a DT cord-002490-kw8psrmz 44 9 level level NN cord-002490-kw8psrmz 44 10 that that WDT cord-002490-kw8psrmz 44 11 removes remove VBZ cord-002490-kw8psrmz 44 12 the the DT cord-002490-kw8psrmz 44 13 lipid lipid NN cord-002490-kw8psrmz 44 14 bilayer bilayer NN cord-002490-kw8psrmz 44 15 from from IN cord-002490-kw8psrmz 44 16 display display NN cord-002490-kw8psrmz 44 17 , , , cord-002490-kw8psrmz 44 18 the the DT cord-002490-kw8psrmz 44 19 stalk stalk NN cord-002490-kw8psrmz 44 20 still still RB cord-002490-kw8psrmz 44 21 conforms conform VBZ cord-002490-kw8psrmz 44 22 closely closely RB cord-002490-kw8psrmz 44 23 to to IN cord-002490-kw8psrmz 44 24 the the DT cord-002490-kw8psrmz 44 25 surface surface NN cord-002490-kw8psrmz 44 26 of of IN cord-002490-kw8psrmz 44 27 the the DT cord-002490-kw8psrmz 44 28 atomic atomic JJ cord-002490-kw8psrmz 44 29 resolution resolution NN cord-002490-kw8psrmz 44 30 structure structure NN cord-002490-kw8psrmz 44 31 , , , cord-002490-kw8psrmz 44 32 whereas whereas IN cord-002490-kw8psrmz 44 33 there there RB cord-002490-kw8psrmz 44 34 distal distal JJ cord-002490-kw8psrmz 44 35 ends end NNS cord-002490-kw8psrmz 44 36 of of IN cord-002490-kw8psrmz 44 37 the the DT cord-002490-kw8psrmz 44 38 blades blade NNS cord-002490-kw8psrmz 44 39 and and CC cord-002490-kw8psrmz 44 40 the the DT cord-002490-kw8psrmz 44 41 glycan glycan NN cord-002490-kw8psrmz 44 42 cap cap NN cord-002490-kw8psrmz 44 43 " " `` cord-002490-kw8psrmz 44 44 nubs nub NNS cord-002490-kw8psrmz 44 45 " " '' cord-002490-kw8psrmz 44 46 are be VBP cord-002490-kw8psrmz 44 47 slightly slightly RB cord-002490-kw8psrmz 44 48 truncated truncate VBN cord-002490-kw8psrmz 44 49 . . . cord-002490-kw8psrmz 45 1 This this DT cord-002490-kw8psrmz 45 2 indicates indicate VBZ cord-002490-kw8psrmz 45 3 that that IN cord-002490-kw8psrmz 45 4 these these DT cord-002490-kw8psrmz 45 5 regions region NNS cord-002490-kw8psrmz 45 6 of of IN cord-002490-kw8psrmz 45 7 the the DT cord-002490-kw8psrmz 45 8 structure structure NN cord-002490-kw8psrmz 45 9 probably probably RB cord-002490-kw8psrmz 45 10 have have VBP cord-002490-kw8psrmz 45 11 a a DT cord-002490-kw8psrmz 45 12 lower low JJR cord-002490-kw8psrmz 45 13 density density NN cord-002490-kw8psrmz 45 14 , , , cord-002490-kw8psrmz 45 15 consistent consistent JJ cord-002490-kw8psrmz 45 16 with with IN cord-002490-kw8psrmz 45 17 their -PRON- PRP$ cord-002490-kw8psrmz 45 18 being be VBG cord-002490-kw8psrmz 45 19 highly highly RB cord-002490-kw8psrmz 45 20 glycosylated glycosylate VBN cord-002490-kw8psrmz 45 21 , , , cord-002490-kw8psrmz 45 22 as as IN cord-002490-kw8psrmz 45 23 predicted predict VBN cord-002490-kw8psrmz 45 24 by by IN cord-002490-kw8psrmz 45 25 the the DT cord-002490-kw8psrmz 45 26 amino amino NN cord-002490-kw8psrmz 45 27 acid acid NN cord-002490-kw8psrmz 45 28 sequence sequence NN cord-002490-kw8psrmz 45 29 of of IN cord-002490-kw8psrmz 45 30 the the DT cord-002490-kw8psrmz 45 31 mucin mucin NN cord-002490-kw8psrmz 45 32 - - HYPH cord-002490-kw8psrmz 45 33 like like JJ cord-002490-kw8psrmz 45 34 domain domain NN cord-002490-kw8psrmz 45 35 . . . cord-002490-kw8psrmz 46 1 We -PRON- PRP cord-002490-kw8psrmz 46 2 also also RB cord-002490-kw8psrmz 46 3 docked dock VBD cord-002490-kw8psrmz 46 4 the the DT cord-002490-kw8psrmz 46 5 5JNX 5jnx CD cord-002490-kw8psrmz 46 6 structure structure NN cord-002490-kw8psrmz 46 7 36 36 CD cord-002490-kw8psrmz 46 8 , , , cord-002490-kw8psrmz 46 9 which which WDT cord-002490-kw8psrmz 46 10 includes include VBZ cord-002490-kw8psrmz 46 11 part part NN cord-002490-kw8psrmz 46 12 of of IN cord-002490-kw8psrmz 46 13 the the DT cord-002490-kw8psrmz 46 14 cleaved cleaved JJ cord-002490-kw8psrmz 46 15 glycoprotein glycoprotein NN cord-002490-kw8psrmz 46 16 ( ( -LRB- cord-002490-kw8psrmz 46 17 GPcl GPcl NNP cord-002490-kw8psrmz 46 18 ) ) -RRB- cord-002490-kw8psrmz 46 19 in in IN cord-002490-kw8psrmz 46 20 complex complex NN cord-002490-kw8psrmz 46 21 with with IN cord-002490-kw8psrmz 46 22 full full JJ cord-002490-kw8psrmz 46 23 - - HYPH cord-002490-kw8psrmz 46 24 length length NN cord-002490-kw8psrmz 46 25 human human JJ cord-002490-kw8psrmz 46 26 NPC1 NPC1 NNP cord-002490-kw8psrmz 46 27 , , , cord-002490-kw8psrmz 46 28 and and CC cord-002490-kw8psrmz 46 29 and and CC cord-002490-kw8psrmz 46 30 5JNX 5JNX NNP cord-002490-kw8psrmz 46 31 ( ( -LRB- cord-002490-kw8psrmz 46 32 NPC1-GP NPC1-GP NNP cord-002490-kw8psrmz 46 33 , , , cord-002490-kw8psrmz 46 34 magenta magenta NN cord-002490-kw8psrmz 46 35 ) ) -RRB- cord-002490-kw8psrmz 46 36 were be VBD cord-002490-kw8psrmz 46 37 docked dock VBN cord-002490-kw8psrmz 46 38 within within IN cord-002490-kw8psrmz 46 39 the the DT cord-002490-kw8psrmz 46 40 Ebola Ebola NNP cord-002490-kw8psrmz 46 41 GP GP NNP cord-002490-kw8psrmz 46 42 using use VBG cord-002490-kw8psrmz 46 43 Chimera Chimera NNP cord-002490-kw8psrmz 46 44 ( ( -LRB- cord-002490-kw8psrmz 46 45 GP gp NN cord-002490-kw8psrmz 46 46 trimer trimer NN cord-002490-kw8psrmz 46 47 subunits subunit NNS cord-002490-kw8psrmz 46 48 coloured colour VBN cord-002490-kw8psrmz 46 49 in in IN cord-002490-kw8psrmz 46 50 green green JJ cord-002490-kw8psrmz 46 51 , , , cord-002490-kw8psrmz 46 52 blue blue JJ cord-002490-kw8psrmz 46 53 and and CC cord-002490-kw8psrmz 46 54 yellow yellow JJ cord-002490-kw8psrmz 46 55 ; ; : cord-002490-kw8psrmz 46 56 NPC1-GP NPC1-GP NNP cord-002490-kw8psrmz 46 57 in in IN cord-002490-kw8psrmz 46 58 magenta magenta NN cord-002490-kw8psrmz 46 59 ) ) -RRB- cord-002490-kw8psrmz 46 60 . . . cord-002490-kw8psrmz 47 1 The the DT cord-002490-kw8psrmz 47 2 cryo cryo NN cord-002490-kw8psrmz 47 3 - - HYPH cord-002490-kw8psrmz 47 4 EM em NN cord-002490-kw8psrmz 47 5 reconstruction reconstruction NN cord-002490-kw8psrmz 47 6 is be VBZ cord-002490-kw8psrmz 47 7 presented present VBN cord-002490-kw8psrmz 47 8 at at IN cord-002490-kw8psrmz 47 9 a a DT cord-002490-kw8psrmz 47 10 threshold threshold NN cord-002490-kw8psrmz 47 11 to to TO cord-002490-kw8psrmz 47 12 show show VB cord-002490-kw8psrmz 47 13 the the DT cord-002490-kw8psrmz 47 14 viral viral JJ cord-002490-kw8psrmz 47 15 envelope envelope NN cord-002490-kw8psrmz 47 16 , , , cord-002490-kw8psrmz 47 17 and and CC cord-002490-kw8psrmz 47 18 using use VBG cord-002490-kw8psrmz 47 19 the the DT cord-002490-kw8psrmz 47 20 same same JJ cord-002490-kw8psrmz 47 21 colour colour NN cord-002490-kw8psrmz 47 22 code code NN cord-002490-kw8psrmz 47 23 as as IN cord-002490-kw8psrmz 47 24 in in IN cord-002490-kw8psrmz 47 25 Fig Fig NNP cord-002490-kw8psrmz 47 26 . . . cord-002490-kw8psrmz 48 1 2 2 LS cord-002490-kw8psrmz 48 2 . . . cord-002490-kw8psrmz 49 1 ( ( -LRB- cord-002490-kw8psrmz 49 2 b b NN cord-002490-kw8psrmz 49 3 ) ) -RRB- cord-002490-kw8psrmz 50 1 The the DT cord-002490-kw8psrmz 50 2 GP GP NNP cord-002490-kw8psrmz 50 3 spike spike NN cord-002490-kw8psrmz 50 4 reconstruction reconstruction NN cord-002490-kw8psrmz 50 5 is be VBZ cord-002490-kw8psrmz 50 6 presented present VBN cord-002490-kw8psrmz 50 7 at at IN cord-002490-kw8psrmz 50 8 a a DT cord-002490-kw8psrmz 50 9 threshold threshold NN cord-002490-kw8psrmz 50 10 equivalent equivalent JJ cord-002490-kw8psrmz 50 11 to to IN cord-002490-kw8psrmz 50 12 its -PRON- PRP$ cord-002490-kw8psrmz 50 13 molecular molecular JJ cord-002490-kw8psrmz 50 14 mass mass NN cord-002490-kw8psrmz 50 15 to to TO cord-002490-kw8psrmz 50 16 illustrate illustrate VB cord-002490-kw8psrmz 50 17 the the DT cord-002490-kw8psrmz 50 18 tight tight JJ cord-002490-kw8psrmz 50 19 fit fit NN cord-002490-kw8psrmz 50 20 of of IN cord-002490-kw8psrmz 50 21 5JQ7 5jq7 CD cord-002490-kw8psrmz 50 22 . . . cord-002490-kw8psrmz 51 1 The the DT cord-002490-kw8psrmz 51 2 inset inset NN cord-002490-kw8psrmz 51 3 shows show VBZ cord-002490-kw8psrmz 51 4 the the DT cord-002490-kw8psrmz 51 5 location location NN cord-002490-kw8psrmz 51 6 of of IN cord-002490-kw8psrmz 51 7 toremifene toremifene NNP cord-002490-kw8psrmz 51 8 ( ( -LRB- cord-002490-kw8psrmz 51 9 red red NNP cord-002490-kw8psrmz 51 10 ) ) -RRB- cord-002490-kw8psrmz 51 11 , , , cord-002490-kw8psrmz 51 12 and and CC cord-002490-kw8psrmz 51 13 the the DT cord-002490-kw8psrmz 51 14 residues residue NNS cord-002490-kw8psrmz 51 15 of of IN cord-002490-kw8psrmz 51 16 the the DT cord-002490-kw8psrmz 51 17 receptor receptor NN cord-002490-kw8psrmz 51 18 - - HYPH cord-002490-kw8psrmz 51 19 binding bind VBG cord-002490-kw8psrmz 51 20 site site NN cord-002490-kw8psrmz 51 21 are be VBP cord-002490-kw8psrmz 51 22 coloured coloured JJ cord-002490-kw8psrmz 51 23 red red JJ cord-002490-kw8psrmz 51 24 . . . cord-002490-kw8psrmz 52 1 ( ( -LRB- cord-002490-kw8psrmz 52 2 c c NN cord-002490-kw8psrmz 52 3 ) ) -RRB- cord-002490-kw8psrmz 53 1 The the DT cord-002490-kw8psrmz 53 2 atomic atomic JJ cord-002490-kw8psrmz 53 3 resolution resolution NN cord-002490-kw8psrmz 53 4 structures structure NNS cord-002490-kw8psrmz 53 5 of of IN cord-002490-kw8psrmz 53 6 the the DT cord-002490-kw8psrmz 53 7 neutralizing neutralize VBG cord-002490-kw8psrmz 53 8 antibodies antibody NNS cord-002490-kw8psrmz 53 9 KZ52 KZ52 NNP cord-002490-kw8psrmz 53 10 Fab Fab NNP cord-002490-kw8psrmz 53 11 ( ( -LRB- cord-002490-kw8psrmz 53 12 3CSY 3csy NN cord-002490-kw8psrmz 53 13 , , , cord-002490-kw8psrmz 53 14 beige beige JJ cord-002490-kw8psrmz 53 15 ) ) -RRB- cord-002490-kw8psrmz 53 16 , , , cord-002490-kw8psrmz 53 17 MR78 MR78 NNP cord-002490-kw8psrmz 53 18 Fab Fab NNP cord-002490-kw8psrmz 53 19 , , , cord-002490-kw8psrmz 53 20 ( ( -LRB- cord-002490-kw8psrmz 53 21 3X2D 3x2d CD cord-002490-kw8psrmz 53 22 , , , cord-002490-kw8psrmz 53 23 pink pink JJ cord-002490-kw8psrmz 53 24 ) ) -RRB- cord-002490-kw8psrmz 53 25 were be VBD cord-002490-kw8psrmz 53 26 docked dock VBN cord-002490-kw8psrmz 53 27 within within IN cord-002490-kw8psrmz 53 28 the the DT cord-002490-kw8psrmz 53 29 Ebola Ebola NNP cord-002490-kw8psrmz 53 30 GP GP NNP cord-002490-kw8psrmz 53 31 using use VBG cord-002490-kw8psrmz 53 32 Chimera Chimera NNP cord-002490-kw8psrmz 53 33 . . . cord-002490-kw8psrmz 54 1 overlaid overlay VBD cord-002490-kw8psrmz 54 2 the the DT cord-002490-kw8psrmz 54 3 atomic atomic JJ cord-002490-kw8psrmz 54 4 resolution resolution NN cord-002490-kw8psrmz 54 5 structure structure NN cord-002490-kw8psrmz 54 6 onto onto IN cord-002490-kw8psrmz 54 7 one one CD cord-002490-kw8psrmz 54 8 monomer monomer NN cord-002490-kw8psrmz 54 9 using use VBG cord-002490-kw8psrmz 54 10 the the DT cord-002490-kw8psrmz 54 11 program program NN cord-002490-kw8psrmz 54 12 module module NN cord-002490-kw8psrmz 54 13 " " `` cord-002490-kw8psrmz 54 14 Fit fit VB cord-002490-kw8psrmz 54 15 in in IN cord-002490-kw8psrmz 54 16 Map Map NNP cord-002490-kw8psrmz 54 17 " " '' cord-002490-kw8psrmz 54 18 in in IN cord-002490-kw8psrmz 54 19 UCSF UCSF NNP cord-002490-kw8psrmz 54 20 Chimera Chimera NNP cord-002490-kw8psrmz 54 21 ( ( -LRB- cord-002490-kw8psrmz 54 22 Fig Fig NNP cord-002490-kw8psrmz 54 23 . . . cord-002490-kw8psrmz 54 24 3a 3a NNP cord-002490-kw8psrmz 54 25 ) ) -RRB- cord-002490-kw8psrmz 54 26 . . . cord-002490-kw8psrmz 55 1 This this DT cord-002490-kw8psrmz 55 2 indicates indicate VBZ cord-002490-kw8psrmz 55 3 that that IN cord-002490-kw8psrmz 55 4 the the DT cord-002490-kw8psrmz 55 5 mucin mucin NN cord-002490-kw8psrmz 55 6 - - HYPH cord-002490-kw8psrmz 55 7 like like JJ cord-002490-kw8psrmz 55 8 domain domain NN cord-002490-kw8psrmz 55 9 , , , cord-002490-kw8psrmz 55 10 ( ( -LRB- cord-002490-kw8psrmz 55 11 all all DT cord-002490-kw8psrmz 55 12 of of IN cord-002490-kw8psrmz 55 13 the the DT cord-002490-kw8psrmz 55 14 unoccupied unoccupied JJ cord-002490-kw8psrmz 55 15 density density NN cord-002490-kw8psrmz 55 16 remaining remain VBG cord-002490-kw8psrmz 55 17 in in IN cord-002490-kw8psrmz 55 18 the the DT cord-002490-kw8psrmz 55 19 3-D 3-d JJ cord-002490-kw8psrmz 55 20 EM EM NNP cord-002490-kw8psrmz 55 21 structure structure NN cord-002490-kw8psrmz 55 22 when when WRB cord-002490-kw8psrmz 55 23 GP1-GP2 GP1-GP2 NNP cord-002490-kw8psrmz 55 24 are be VBP cord-002490-kw8psrmz 55 25 fitted fit VBN cord-002490-kw8psrmz 55 26 ) ) -RRB- cord-002490-kw8psrmz 55 27 completely completely RB cord-002490-kw8psrmz 55 28 covers cover VBZ cord-002490-kw8psrmz 55 29 the the DT cord-002490-kw8psrmz 55 30 glycan glycan NN cord-002490-kw8psrmz 55 31 cap cap NN cord-002490-kw8psrmz 55 32 , , , cord-002490-kw8psrmz 55 33 with with IN cord-002490-kw8psrmz 55 34 the the DT cord-002490-kw8psrmz 55 35 nub nub NN cord-002490-kw8psrmz 55 36 at at IN cord-002490-kw8psrmz 55 37 the the DT cord-002490-kw8psrmz 55 38 side side NN cord-002490-kw8psrmz 55 39 of of IN cord-002490-kw8psrmz 55 40 the the DT cord-002490-kw8psrmz 55 41 propeller propeller NN cord-002490-kw8psrmz 55 42 covering cover VBG cord-002490-kw8psrmz 55 43 most most RBS cord-002490-kw8psrmz 55 44 , , , cord-002490-kw8psrmz 55 45 if if IN cord-002490-kw8psrmz 55 46 not not RB cord-002490-kw8psrmz 55 47 all all DT cord-002490-kw8psrmz 55 48 , , , cord-002490-kw8psrmz 55 49 of of IN cord-002490-kw8psrmz 55 50 the the DT cord-002490-kw8psrmz 55 51 receptor receptor NN cord-002490-kw8psrmz 55 52 binding bind VBG cord-002490-kw8psrmz 55 53 site site NN cord-002490-kw8psrmz 55 54 ( ( -LRB- cord-002490-kw8psrmz 55 55 Fig Fig NNP cord-002490-kw8psrmz 55 56 . . . cord-002490-kw8psrmz 55 57 3a 3a NNP cord-002490-kw8psrmz 55 58 ) ) -RRB- cord-002490-kw8psrmz 55 59 , , , cord-002490-kw8psrmz 55 60 indicating indicate VBG cord-002490-kw8psrmz 55 61 that that IN cord-002490-kw8psrmz 55 62 removal removal NN cord-002490-kw8psrmz 55 63 or or CC cord-002490-kw8psrmz 55 64 cleavage cleavage NN cord-002490-kw8psrmz 55 65 of of IN cord-002490-kw8psrmz 55 66 the the DT cord-002490-kw8psrmz 55 67 mucin mucin NN cord-002490-kw8psrmz 55 68 - - HYPH cord-002490-kw8psrmz 55 69 like like JJ cord-002490-kw8psrmz 55 70 domain domain NN cord-002490-kw8psrmz 55 71 ( ( -LRB- cord-002490-kw8psrmz 55 72 probably probably RB cord-002490-kw8psrmz 55 73 including include VBG cord-002490-kw8psrmz 55 74 the the DT cord-002490-kw8psrmz 55 75 nub nub NN cord-002490-kw8psrmz 55 76 ) ) -RRB- cord-002490-kw8psrmz 55 77 , , , cord-002490-kw8psrmz 55 78 as as RB cord-002490-kw8psrmz 55 79 well well RB cord-002490-kw8psrmz 55 80 as as IN cord-002490-kw8psrmz 55 81 the the DT cord-002490-kw8psrmz 55 82 glycan glycan NN cord-002490-kw8psrmz 55 83 cap cap NN cord-002490-kw8psrmz 55 84 , , , cord-002490-kw8psrmz 55 85 may may MD cord-002490-kw8psrmz 55 86 be be VB cord-002490-kw8psrmz 55 87 prerequisites prerequisite NNS cord-002490-kw8psrmz 55 88 for for IN cord-002490-kw8psrmz 55 89 receptor receptor NN cord-002490-kw8psrmz 55 90 binding binding NN cord-002490-kw8psrmz 55 91 to to TO cord-002490-kw8psrmz 55 92 be be VB cord-002490-kw8psrmz 55 93 achieved achieve VBN cord-002490-kw8psrmz 55 94 . . . cord-002490-kw8psrmz 56 1 The the DT cord-002490-kw8psrmz 56 2 docked dock VBN cord-002490-kw8psrmz 56 3 5JNX 5jnx CD cord-002490-kw8psrmz 56 4 structure structure NN cord-002490-kw8psrmz 56 5 also also RB cord-002490-kw8psrmz 56 6 includes include VBZ cord-002490-kw8psrmz 56 7 the the DT cord-002490-kw8psrmz 56 8 transmembrane transmembrane NN cord-002490-kw8psrmz 56 9 region region NN cord-002490-kw8psrmz 56 10 of of IN cord-002490-kw8psrmz 56 11 NPC1 NPC1 NNP cord-002490-kw8psrmz 56 12 , , , cord-002490-kw8psrmz 56 13 and and CC cord-002490-kw8psrmz 56 14 thus thus RB cord-002490-kw8psrmz 56 15 we -PRON- PRP cord-002490-kw8psrmz 56 16 aligned align VBD cord-002490-kw8psrmz 56 17 the the DT cord-002490-kw8psrmz 56 18 approximate approximate JJ cord-002490-kw8psrmz 56 19 plane plane NN cord-002490-kw8psrmz 56 20 of of IN cord-002490-kw8psrmz 56 21 the the DT cord-002490-kw8psrmz 56 22 plasma plasma NN cord-002490-kw8psrmz 56 23 membrane membrane NN cord-002490-kw8psrmz 56 24 when when WRB cord-002490-kw8psrmz 56 25 the the DT cord-002490-kw8psrmz 56 26 GP GP NNP cord-002490-kw8psrmz 56 27 spike spike NN cord-002490-kw8psrmz 56 28 docks dock NNS cord-002490-kw8psrmz 56 29 with with IN cord-002490-kw8psrmz 56 30 the the DT cord-002490-kw8psrmz 56 31 receptor receptor NN cord-002490-kw8psrmz 56 32 NPC1 NPC1 NNP cord-002490-kw8psrmz 56 33 , , , cord-002490-kw8psrmz 56 34 shown show VBN cord-002490-kw8psrmz 56 35 in in IN cord-002490-kw8psrmz 56 36 transparent transparent JJ cord-002490-kw8psrmz 56 37 blue blue NN cord-002490-kw8psrmz 56 38 in in IN cord-002490-kw8psrmz 56 39 Fig Fig NNP cord-002490-kw8psrmz 56 40 . . . cord-002490-kw8psrmz 57 1 3a 3a NNP cord-002490-kw8psrmz 57 2 . . . cord-002490-kw8psrmz 58 1 In in IN cord-002490-kw8psrmz 58 2 the the DT cord-002490-kw8psrmz 58 3 absence absence NN cord-002490-kw8psrmz 58 4 of of IN cord-002490-kw8psrmz 58 5 any any DT cord-002490-kw8psrmz 58 6 bending bending NN cord-002490-kw8psrmz 58 7 of of IN cord-002490-kw8psrmz 58 8 endosomal endosomal JJ cord-002490-kw8psrmz 58 9 membrane membrane NN cord-002490-kw8psrmz 58 10 to to TO cord-002490-kw8psrmz 58 11 accommodate accommodate VB cord-002490-kw8psrmz 58 12 the the DT cord-002490-kw8psrmz 58 13 contour contour NN cord-002490-kw8psrmz 58 14 of of IN cord-002490-kw8psrmz 58 15 the the DT cord-002490-kw8psrmz 58 16 GP GP NNP cord-002490-kw8psrmz 58 17 trimer trimer NN cord-002490-kw8psrmz 58 18 and and CC cord-002490-kw8psrmz 58 19 NPC1 NPC1 NNP cord-002490-kw8psrmz 58 20 complex complex NN cord-002490-kw8psrmz 58 21 , , , cord-002490-kw8psrmz 58 22 the the DT cord-002490-kw8psrmz 58 23 plane plane NN cord-002490-kw8psrmz 58 24 of of IN cord-002490-kw8psrmz 58 25 the the DT cord-002490-kw8psrmz 58 26 plasma plasma NN cord-002490-kw8psrmz 58 27 membrane membrane NN cord-002490-kw8psrmz 58 28 would would MD cord-002490-kw8psrmz 58 29 make make VB cord-002490-kw8psrmz 58 30 an an DT cord-002490-kw8psrmz 58 31 angle angle NN cord-002490-kw8psrmz 58 32 of of IN cord-002490-kw8psrmz 58 33 about about RB cord-002490-kw8psrmz 58 34 18 18 CD cord-002490-kw8psrmz 58 35 degrees degree NNS cord-002490-kw8psrmz 58 36 from from IN cord-002490-kw8psrmz 58 37 the the DT cord-002490-kw8psrmz 58 38 viral viral JJ cord-002490-kw8psrmz 58 39 membrane membrane NN cord-002490-kw8psrmz 58 40 when when WRB cord-002490-kw8psrmz 58 41 the the DT cord-002490-kw8psrmz 58 42 spike spike NN cord-002490-kw8psrmz 58 43 is be VBZ cord-002490-kw8psrmz 58 44 perpendicular perpendicular JJ cord-002490-kw8psrmz 58 45 to to IN cord-002490-kw8psrmz 58 46 the the DT cord-002490-kw8psrmz 58 47 viral viral JJ cord-002490-kw8psrmz 58 48 envelope envelope NN cord-002490-kw8psrmz 58 49 ( ( -LRB- cord-002490-kw8psrmz 58 50 Fig Fig NNP cord-002490-kw8psrmz 58 51 . . . cord-002490-kw8psrmz 58 52 3a 3a NNP cord-002490-kw8psrmz 58 53 ) ) -RRB- cord-002490-kw8psrmz 58 54 . . . cord-002490-kw8psrmz 59 1 This this DT cord-002490-kw8psrmz 59 2 is be VBZ cord-002490-kw8psrmz 59 3 consistent consistent JJ cord-002490-kw8psrmz 59 4 with with IN cord-002490-kw8psrmz 59 5 the the DT cord-002490-kw8psrmz 59 6 suggestion suggestion NN cord-002490-kw8psrmz 59 7 by by IN cord-002490-kw8psrmz 59 8 Gong Gong NNP cord-002490-kw8psrmz 59 9 et et FW cord-002490-kw8psrmz 59 10 al al NNP cord-002490-kw8psrmz 59 11 . . . cord-002490-kw8psrmz 60 1 36 36 CD cord-002490-kw8psrmz 60 2 that that IN cord-002490-kw8psrmz 60 3 perhaps perhaps RB cord-002490-kw8psrmz 60 4 only only RB cord-002490-kw8psrmz 60 5 one one CD cord-002490-kw8psrmz 60 6 NPC1-receptor NPC1-receptor NNP cord-002490-kw8psrmz 60 7 binding binding NN cord-002490-kw8psrmz 60 8 site site NN cord-002490-kw8psrmz 60 9 out out IN cord-002490-kw8psrmz 60 10 of of IN cord-002490-kw8psrmz 60 11 three three CD cord-002490-kw8psrmz 60 12 on on IN cord-002490-kw8psrmz 60 13 each each DT cord-002490-kw8psrmz 60 14 trimer trimer NN cord-002490-kw8psrmz 60 15 can can MD cord-002490-kw8psrmz 60 16 be be VB cord-002490-kw8psrmz 60 17 occupied occupy VBN cord-002490-kw8psrmz 60 18 at at IN cord-002490-kw8psrmz 60 19 once once RB cord-002490-kw8psrmz 60 20 , , , cord-002490-kw8psrmz 60 21 and and CC cord-002490-kw8psrmz 60 22 that that IN cord-002490-kw8psrmz 60 23 binding bind VBG cord-002490-kw8psrmz 60 24 to to IN cord-002490-kw8psrmz 60 25 more more JJR cord-002490-kw8psrmz 60 26 than than IN cord-002490-kw8psrmz 60 27 one one CD cord-002490-kw8psrmz 60 28 receptor receptor NN cord-002490-kw8psrmz 60 29 might may MD cord-002490-kw8psrmz 60 30 be be VB cord-002490-kw8psrmz 60 31 precluded preclude VBN cord-002490-kw8psrmz 60 32 due due IN cord-002490-kw8psrmz 60 33 to to IN cord-002490-kw8psrmz 60 34 stearic stearic JJ cord-002490-kw8psrmz 60 35 interference interference NN cord-002490-kw8psrmz 60 36 . . . cord-002490-kw8psrmz 61 1 The the DT cord-002490-kw8psrmz 61 2 possible possible JJ cord-002490-kw8psrmz 61 3 line line NN cord-002490-kw8psrmz 61 4 of of IN cord-002490-kw8psrmz 61 5 cleavage cleavage NN cord-002490-kw8psrmz 61 6 delineating delineate VBG cord-002490-kw8psrmz 61 7 the the DT cord-002490-kw8psrmz 61 8 mucin mucin NN cord-002490-kw8psrmz 61 9 - - HYPH cord-002490-kw8psrmz 61 10 like like JJ cord-002490-kw8psrmz 61 11 domain domain NN cord-002490-kw8psrmz 61 12 and and CC cord-002490-kw8psrmz 61 13 glycan glycan NN cord-002490-kw8psrmz 61 14 cap cap NN cord-002490-kw8psrmz 61 15 from from IN cord-002490-kw8psrmz 61 16 the the DT cord-002490-kw8psrmz 61 17 rest rest NN cord-002490-kw8psrmz 61 18 of of IN cord-002490-kw8psrmz 61 19 the the DT cord-002490-kw8psrmz 61 20 trimer trimer NN cord-002490-kw8psrmz 61 21 is be VBZ cord-002490-kw8psrmz 61 22 shown show VBN cord-002490-kw8psrmz 61 23 in in IN cord-002490-kw8psrmz 61 24 Fig Fig NNP cord-002490-kw8psrmz 61 25 . . . cord-002490-kw8psrmz 62 1 3a 3a NNP cord-002490-kw8psrmz 62 2 and and CC cord-002490-kw8psrmz 62 3 b. b. NNP cord-002490-kw8psrmz 62 4 Our -PRON- PRP$ cord-002490-kw8psrmz 62 5 structure structure NN cord-002490-kw8psrmz 62 6 suggests suggest VBZ cord-002490-kw8psrmz 62 7 that that IN cord-002490-kw8psrmz 62 8 the the DT cord-002490-kw8psrmz 62 9 mucin mucin NN cord-002490-kw8psrmz 62 10 - - HYPH cord-002490-kw8psrmz 62 11 like like JJ cord-002490-kw8psrmz 62 12 domain domain NN cord-002490-kw8psrmz 62 13 and and CC cord-002490-kw8psrmz 62 14 the the DT cord-002490-kw8psrmz 62 15 glycan glycan NN cord-002490-kw8psrmz 62 16 cap cap NN cord-002490-kw8psrmz 62 17 might may MD cord-002490-kw8psrmz 62 18 be be VB cord-002490-kw8psrmz 62 19 cleaved cleave VBN cord-002490-kw8psrmz 62 20 at at IN cord-002490-kw8psrmz 62 21 the the DT cord-002490-kw8psrmz 62 22 same same JJ cord-002490-kw8psrmz 62 23 time time NN cord-002490-kw8psrmz 62 24 , , , cord-002490-kw8psrmz 62 25 since since IN cord-002490-kw8psrmz 62 26 the the DT cord-002490-kw8psrmz 62 27 latter latter JJ cord-002490-kw8psrmz 62 28 is be VBZ cord-002490-kw8psrmz 62 29 entirely entirely RB cord-002490-kw8psrmz 62 30 within within IN cord-002490-kw8psrmz 62 31 the the DT cord-002490-kw8psrmz 62 32 density density NN cord-002490-kw8psrmz 62 33 of of IN cord-002490-kw8psrmz 62 34 the the DT cord-002490-kw8psrmz 62 35 putative putative JJ cord-002490-kw8psrmz 62 36 mucin mucin NN cord-002490-kw8psrmz 62 37 - - HYPH cord-002490-kw8psrmz 62 38 like like JJ cord-002490-kw8psrmz 62 39 domain domain NN cord-002490-kw8psrmz 62 40 , , , cord-002490-kw8psrmz 62 41 and and CC cord-002490-kw8psrmz 62 42 is be VBZ cord-002490-kw8psrmz 62 43 consistent consistent JJ cord-002490-kw8psrmz 62 44 with with IN cord-002490-kw8psrmz 62 45 a a DT cord-002490-kw8psrmz 62 46 molecular molecular JJ cord-002490-kw8psrmz 62 47 weight weight NN cord-002490-kw8psrmz 62 48 for for IN cord-002490-kw8psrmz 62 49 the the DT cord-002490-kw8psrmz 62 50 mucin mucin NN cord-002490-kw8psrmz 62 51 - - HYPH cord-002490-kw8psrmz 62 52 like like JJ cord-002490-kw8psrmz 62 53 domain domain NN cord-002490-kw8psrmz 62 54 of of IN cord-002490-kw8psrmz 62 55 about about RB cord-002490-kw8psrmz 62 56 50 50 CD cord-002490-kw8psrmz 62 57 kDa kDa NNS cord-002490-kw8psrmz 62 58 , , , cord-002490-kw8psrmz 62 59 which which WDT cord-002490-kw8psrmz 62 60 is be VBZ cord-002490-kw8psrmz 62 61 similar similar JJ cord-002490-kw8psrmz 62 62 to to IN cord-002490-kw8psrmz 62 63 that that DT cord-002490-kw8psrmz 62 64 predicted predict VBN cord-002490-kw8psrmz 62 65 by by IN cord-002490-kw8psrmz 62 66 the the DT cord-002490-kw8psrmz 62 67 sequence sequence NN cord-002490-kw8psrmz 62 68 as as RB cord-002490-kw8psrmz 62 69 well well RB cord-002490-kw8psrmz 62 70 as as IN cord-002490-kw8psrmz 62 71 gel gel NN cord-002490-kw8psrmz 62 72 electrophoresis electrophoresis NN cord-002490-kw8psrmz 62 73 , , , cord-002490-kw8psrmz 62 74 although although IN cord-002490-kw8psrmz 62 75 the the DT cord-002490-kw8psrmz 62 76 length length NN cord-002490-kw8psrmz 62 77 of of IN cord-002490-kw8psrmz 62 78 the the DT cord-002490-kw8psrmz 62 79 sugar sugar NN cord-002490-kw8psrmz 62 80 side side NN cord-002490-kw8psrmz 62 81 - - HYPH cord-002490-kw8psrmz 62 82 chains chain NNS cord-002490-kw8psrmz 62 83 is be VBZ cord-002490-kw8psrmz 62 84 still still RB cord-002490-kw8psrmz 62 85 unknown unknown JJ cord-002490-kw8psrmz 62 86 . . . cord-002490-kw8psrmz 63 1 In in IN cord-002490-kw8psrmz 63 2 addition addition NN cord-002490-kw8psrmz 63 3 , , , cord-002490-kw8psrmz 63 4 we -PRON- PRP cord-002490-kw8psrmz 63 5 fitted fit VBD cord-002490-kw8psrmz 63 6 the the DT cord-002490-kw8psrmz 63 7 atomic atomic JJ cord-002490-kw8psrmz 63 8 - - HYPH cord-002490-kw8psrmz 63 9 resolution resolution NN cord-002490-kw8psrmz 63 10 Fab fab JJ cord-002490-kw8psrmz 63 11 antibody antibody NN cord-002490-kw8psrmz 63 12 - - HYPH cord-002490-kw8psrmz 63 13 GP gp NN cord-002490-kw8psrmz 63 14 structures structure NNS cord-002490-kw8psrmz 63 15 that that WDT cord-002490-kw8psrmz 63 16 bind bind VBP cord-002490-kw8psrmz 63 17 to to IN cord-002490-kw8psrmz 63 18 each each DT cord-002490-kw8psrmz 63 19 of of IN cord-002490-kw8psrmz 63 20 the the DT cord-002490-kw8psrmz 63 21 two two CD cord-002490-kw8psrmz 63 22 major major JJ cord-002490-kw8psrmz 63 23 EBOV EBOV NNP cord-002490-kw8psrmz 63 24 GP GP NNP cord-002490-kw8psrmz 63 25 neutralising neutralise VBG cord-002490-kw8psrmz 63 26 epitopes epitope NNS cord-002490-kw8psrmz 63 27 that that WDT cord-002490-kw8psrmz 63 28 have have VBP cord-002490-kw8psrmz 63 29 been be VBN cord-002490-kw8psrmz 63 30 previously previously RB cord-002490-kw8psrmz 63 31 investigated investigate VBN cord-002490-kw8psrmz 63 32 , , , cord-002490-kw8psrmz 63 33 MR78 MR78 NNP cord-002490-kw8psrmz 63 34 ( ( -LRB- cord-002490-kw8psrmz 63 35 3X2D 3x2d CD cord-002490-kw8psrmz 63 36 15 15 CD cord-002490-kw8psrmz 63 37 ) ) -RRB- cord-002490-kw8psrmz 63 38 and and CC cord-002490-kw8psrmz 63 39 KZ52 KZ52 NNP cord-002490-kw8psrmz 63 40 ( ( -LRB- cord-002490-kw8psrmz 63 41 3CSY 3csy NN cord-002490-kw8psrmz 63 42 18 18 CD cord-002490-kw8psrmz 63 43 ): ): NN cord-002490-kw8psrmz 64 1 ( ( -LRB- cord-002490-kw8psrmz 64 2 Fig Fig NNP cord-002490-kw8psrmz 64 3 . . . cord-002490-kw8psrmz 64 4 3c 3c NNP cord-002490-kw8psrmz 64 5 ) ) -RRB- cord-002490-kw8psrmz 64 6 . . . cord-002490-kw8psrmz 65 1 This this DT cord-002490-kw8psrmz 65 2 indicates indicate VBZ cord-002490-kw8psrmz 65 3 that that IN cord-002490-kw8psrmz 65 4 , , , cord-002490-kw8psrmz 65 5 within within IN cord-002490-kw8psrmz 65 6 the the DT cord-002490-kw8psrmz 65 7 limitations limitation NNS cord-002490-kw8psrmz 65 8 of of IN cord-002490-kw8psrmz 65 9 the the DT cord-002490-kw8psrmz 65 10 resolution resolution NN cord-002490-kw8psrmz 65 11 achieved achieve VBN cord-002490-kw8psrmz 65 12 in in IN cord-002490-kw8psrmz 65 13 our -PRON- PRP$ cord-002490-kw8psrmz 65 14 3-D 3-d JJ cord-002490-kw8psrmz 65 15 structure structure NN cord-002490-kw8psrmz 65 16 of of IN cord-002490-kw8psrmz 65 17 the the DT cord-002490-kw8psrmz 65 18 spike spike NN cord-002490-kw8psrmz 65 19 in in IN cord-002490-kw8psrmz 65 20 situ situ NN cord-002490-kw8psrmz 65 21 in in IN cord-002490-kw8psrmz 65 22 the the DT cord-002490-kw8psrmz 65 23 envelope envelope NN cord-002490-kw8psrmz 65 24 , , , cord-002490-kw8psrmz 65 25 the the DT cord-002490-kw8psrmz 65 26 putative putative JJ cord-002490-kw8psrmz 65 27 mucin mucin NN cord-002490-kw8psrmz 65 28 - - HYPH cord-002490-kw8psrmz 65 29 like like JJ cord-002490-kw8psrmz 65 30 domain domain NN cord-002490-kw8psrmz 65 31 ( ( -LRB- cord-002490-kw8psrmz 65 32 likely likely JJ cord-002490-kw8psrmz 65 33 to to TO cord-002490-kw8psrmz 65 34 consist consist VB cord-002490-kw8psrmz 65 35 of of IN cord-002490-kw8psrmz 65 36 the the DT cord-002490-kw8psrmz 65 37 propeller propeller NN cord-002490-kw8psrmz 65 38 blade blade NN cord-002490-kw8psrmz 65 39 and and CC cord-002490-kw8psrmz 65 40 possibly possibly RB cord-002490-kw8psrmz 65 41 the the DT cord-002490-kw8psrmz 65 42 nub nub NN cord-002490-kw8psrmz 65 43 features feature VBZ cord-002490-kw8psrmz 65 44 described describe VBN cord-002490-kw8psrmz 65 45 here here RB cord-002490-kw8psrmz 65 46 ) ) -RRB- cord-002490-kw8psrmz 65 47 is be VBZ cord-002490-kw8psrmz 65 48 unlikely unlikely JJ cord-002490-kw8psrmz 65 49 to to TO cord-002490-kw8psrmz 65 50 interfere interfere VB cord-002490-kw8psrmz 65 51 or or CC cord-002490-kw8psrmz 65 52 stearically stearically RB cord-002490-kw8psrmz 65 53 hinder hinder VB cord-002490-kw8psrmz 65 54 either either DT cord-002490-kw8psrmz 65 55 of of IN cord-002490-kw8psrmz 65 56 these these DT cord-002490-kw8psrmz 65 57 antibody antibody NN cord-002490-kw8psrmz 65 58 neutralisation neutralisation NN cord-002490-kw8psrmz 65 59 sites site NNS cord-002490-kw8psrmz 65 60 , , , cord-002490-kw8psrmz 65 61 consistent consistent JJ cord-002490-kw8psrmz 65 62 with with IN cord-002490-kw8psrmz 65 63 neutralisation neutralisation NN cord-002490-kw8psrmz 65 64 being be VBG cord-002490-kw8psrmz 65 65 possible possible JJ cord-002490-kw8psrmz 65 66 prior prior RB cord-002490-kw8psrmz 65 67 to to IN cord-002490-kw8psrmz 65 68 cleavage cleavage NN cord-002490-kw8psrmz 65 69 of of IN cord-002490-kw8psrmz 65 70 the the DT cord-002490-kw8psrmz 65 71 mucin mucin NN cord-002490-kw8psrmz 65 72 - - HYPH cord-002490-kw8psrmz 65 73 like like JJ cord-002490-kw8psrmz 65 74 domain domain NN cord-002490-kw8psrmz 65 75 in in IN cord-002490-kw8psrmz 65 76 the the DT cord-002490-kw8psrmz 65 77 endosome endosome NN cord-002490-kw8psrmz 65 78 . . . cord-002490-kw8psrmz 66 1 It -PRON- PRP cord-002490-kw8psrmz 66 2 is be VBZ cord-002490-kw8psrmz 66 3 clear clear JJ cord-002490-kw8psrmz 66 4 that that IN cord-002490-kw8psrmz 66 5 our -PRON- PRP$ cord-002490-kw8psrmz 66 6 structure structure NN cord-002490-kw8psrmz 66 7 differs differ VBZ cord-002490-kw8psrmz 66 8 from from IN cord-002490-kw8psrmz 66 9 the the DT cord-002490-kw8psrmz 66 10 3-D 3-d JJ cord-002490-kw8psrmz 66 11 EM EM NNP cord-002490-kw8psrmz 66 12 structures structure NNS cord-002490-kw8psrmz 66 13 of of IN cord-002490-kw8psrmz 66 14 the the DT cord-002490-kw8psrmz 66 15 heterologously heterologously NNP cord-002490-kw8psrmz 66 16 - - HYPH cord-002490-kw8psrmz 66 17 expressed express VBN cord-002490-kw8psrmz 66 18 Ebola Ebola NNP cord-002490-kw8psrmz 66 19 GP GP NNP cord-002490-kw8psrmz 66 20 spike spike NN cord-002490-kw8psrmz 66 21 observed observe VBD cord-002490-kw8psrmz 66 22 in in IN cord-002490-kw8psrmz 66 23 situ situ NNS cord-002490-kw8psrmz 66 24 in in IN cord-002490-kw8psrmz 66 25 the the DT cord-002490-kw8psrmz 66 26 plasma plasma NN cord-002490-kw8psrmz 66 27 membrane membrane NN cord-002490-kw8psrmz 66 28 previously previously RB cord-002490-kw8psrmz 66 29 published publish VBN cord-002490-kw8psrmz 66 30 by by IN cord-002490-kw8psrmz 66 31 us -PRON- PRP cord-002490-kw8psrmz 66 32 and and CC cord-002490-kw8psrmz 66 33 others other NNS cord-002490-kw8psrmz 67 1 ( ( -LRB- cord-002490-kw8psrmz 67 2 Fig Fig NNP cord-002490-kw8psrmz 67 3 . . NNP cord-002490-kw8psrmz 67 4 4 4 CD cord-002490-kw8psrmz 67 5 ) ) -RRB- cord-002490-kw8psrmz 67 6 . . . cord-002490-kw8psrmz 68 1 Both both DT cord-002490-kw8psrmz 68 2 of of IN cord-002490-kw8psrmz 68 3 these these DT cord-002490-kw8psrmz 68 4 structures structure NNS cord-002490-kw8psrmz 68 5 included include VBD cord-002490-kw8psrmz 68 6 engineered engineer VBN cord-002490-kw8psrmz 68 7 expressed express VBD cord-002490-kw8psrmz 68 8 material material NN cord-002490-kw8psrmz 68 9 using use VBG cord-002490-kw8psrmz 68 10 mutated mutate VBN cord-002490-kw8psrmz 68 11 or or CC cord-002490-kw8psrmz 68 12 partially partially RB cord-002490-kw8psrmz 68 13 sequence sequence NN cord-002490-kw8psrmz 68 14 - - HYPH cord-002490-kw8psrmz 68 15 truncated truncate VBN cord-002490-kw8psrmz 68 16 proteins protein NNS cord-002490-kw8psrmz 68 17 made make VBN cord-002490-kw8psrmz 68 18 in in IN cord-002490-kw8psrmz 68 19 virus virus NN cord-002490-kw8psrmz 68 20 - - HYPH cord-002490-kw8psrmz 68 21 like like JJ cord-002490-kw8psrmz 68 22 particles particle NNS cord-002490-kw8psrmz 68 23 . . . cord-002490-kw8psrmz 69 1 The the DT cord-002490-kw8psrmz 69 2 spike spike NN cord-002490-kw8psrmz 69 3 structure structure NN cord-002490-kw8psrmz 69 4 of of IN cord-002490-kw8psrmz 69 5 Beniac Beniac NNP cord-002490-kw8psrmz 69 6 et et NNP cord-002490-kw8psrmz 69 7 al al NNP cord-002490-kw8psrmz 69 8 imaged image VBD cord-002490-kw8psrmz 69 9 within within IN cord-002490-kw8psrmz 69 10 the the DT cord-002490-kw8psrmz 69 11 virus virus NN cord-002490-kw8psrmz 69 12 - - HYPH cord-002490-kw8psrmz 69 13 like like JJ cord-002490-kw8psrmz 69 14 particles particle NNS cord-002490-kw8psrmz 69 15 was be VBD cord-002490-kw8psrmz 69 16 somehow somehow RB cord-002490-kw8psrmz 69 17 clipped clip VBN cord-002490-kw8psrmz 69 18 , , , cord-002490-kw8psrmz 69 19 since since IN cord-002490-kw8psrmz 69 20 this this DT cord-002490-kw8psrmz 69 21 should should MD cord-002490-kw8psrmz 69 22 have have VB cord-002490-kw8psrmz 69 23 included include VBN cord-002490-kw8psrmz 69 24 the the DT cord-002490-kw8psrmz 69 25 mucin mucin NN cord-002490-kw8psrmz 69 26 - - HYPH cord-002490-kw8psrmz 69 27 like like JJ cord-002490-kw8psrmz 69 28 domains domain NNS cord-002490-kw8psrmz 69 29 : : : cord-002490-kw8psrmz 70 1 in in IN cord-002490-kw8psrmz 70 2 addition addition NN cord-002490-kw8psrmz 70 3 , , , cord-002490-kw8psrmz 70 4 tomography tomography NN cord-002490-kw8psrmz 70 5 was be VBD cord-002490-kw8psrmz 70 6 combined combine VBN cord-002490-kw8psrmz 70 7 with with IN cord-002490-kw8psrmz 70 8 single single JJ cord-002490-kw8psrmz 70 9 - - HYPH cord-002490-kw8psrmz 70 10 particle particle NN cord-002490-kw8psrmz 70 11 analysis analysis NN cord-002490-kw8psrmz 70 12 , , , cord-002490-kw8psrmz 70 13 which which WDT cord-002490-kw8psrmz 70 14 may may MD cord-002490-kw8psrmz 70 15 have have VB cord-002490-kw8psrmz 70 16 distorted distort VBN cord-002490-kw8psrmz 70 17 the the DT cord-002490-kw8psrmz 70 18 results result NNS cord-002490-kw8psrmz 70 19 4 4 CD cord-002490-kw8psrmz 70 20 . . . cord-002490-kw8psrmz 71 1 The the DT cord-002490-kw8psrmz 71 2 structure structure NN cord-002490-kw8psrmz 71 3 that that WDT cord-002490-kw8psrmz 71 4 we -PRON- PRP cord-002490-kw8psrmz 71 5 report report VBP cord-002490-kw8psrmz 71 6 here here RB cord-002490-kw8psrmz 71 7 is be VBZ cord-002490-kw8psrmz 71 8 based base VBN cord-002490-kw8psrmz 71 9 entirely entirely RB cord-002490-kw8psrmz 71 10 on on IN cord-002490-kw8psrmz 71 11 the the DT cord-002490-kw8psrmz 71 12 well well RB cord-002490-kw8psrmz 71 13 - - HYPH cord-002490-kw8psrmz 71 14 accepted accept VBN cord-002490-kw8psrmz 71 15 method method NN cord-002490-kw8psrmz 71 16 of of IN cord-002490-kw8psrmz 71 17 single single JJ cord-002490-kw8psrmz 71 18 - - HYPH cord-002490-kw8psrmz 71 19 particle particle NN cord-002490-kw8psrmz 71 20 analysis analysis NN cord-002490-kw8psrmz 71 21 using use VBG cord-002490-kw8psrmz 71 22 projection projection NN cord-002490-kw8psrmz 71 23 matching matching NN cord-002490-kw8psrmz 71 24 , , , cord-002490-kw8psrmz 71 25 and and CC cord-002490-kw8psrmz 71 26 is be VBZ cord-002490-kw8psrmz 71 27 broadly broadly RB cord-002490-kw8psrmz 71 28 similar similar JJ cord-002490-kw8psrmz 71 29 to to IN cord-002490-kw8psrmz 71 30 that that DT cord-002490-kw8psrmz 71 31 published publish VBN cord-002490-kw8psrmz 71 32 of of IN cord-002490-kw8psrmz 71 33 expressed express VBN cord-002490-kw8psrmz 71 34 GP GP NNP cord-002490-kw8psrmz 71 35 in in IN cord-002490-kw8psrmz 71 36 virus virus NN cord-002490-kw8psrmz 71 37 - - HYPH cord-002490-kw8psrmz 71 38 like like JJ cord-002490-kw8psrmz 71 39 particles particle NNS cord-002490-kw8psrmz 71 40 using use VBG cord-002490-kw8psrmz 71 41 tomography tomography NNP cord-002490-kw8psrmz 71 42 28 28 CD cord-002490-kw8psrmz 71 43 , , , cord-002490-kw8psrmz 71 44 29 29 CD cord-002490-kw8psrmz 71 45 : : : cord-002490-kw8psrmz 71 46 there there EX cord-002490-kw8psrmz 71 47 are be VBP cord-002490-kw8psrmz 71 48 noticeable noticeable JJ cord-002490-kw8psrmz 71 49 differences difference NNS cord-002490-kw8psrmz 71 50 in in IN cord-002490-kw8psrmz 71 51 shape shape NN cord-002490-kw8psrmz 71 52 and and CC cord-002490-kw8psrmz 71 53 size size NN cord-002490-kw8psrmz 71 54 of of IN cord-002490-kw8psrmz 71 55 the the DT cord-002490-kw8psrmz 71 56 spike spike NN cord-002490-kw8psrmz 71 57 , , , cord-002490-kw8psrmz 71 58 as as RB cord-002490-kw8psrmz 71 59 well well RB cord-002490-kw8psrmz 71 60 as as IN cord-002490-kw8psrmz 71 61 in in IN cord-002490-kw8psrmz 71 62 resolution resolution NN cord-002490-kw8psrmz 71 63 ( ( -LRB- cord-002490-kw8psrmz 71 64 Fig Fig NNP cord-002490-kw8psrmz 71 65 . . NNP cord-002490-kw8psrmz 71 66 4 4 CD cord-002490-kw8psrmz 71 67 ) ) -RRB- cord-002490-kw8psrmz 71 68 . . . cord-002490-kw8psrmz 72 1 The the DT cord-002490-kw8psrmz 72 2 previously previously RB cord-002490-kw8psrmz 72 3 determined determine VBN cord-002490-kw8psrmz 72 4 atomic atomic JJ cord-002490-kw8psrmz 72 5 resolution resolution NN cord-002490-kw8psrmz 72 6 structures structure NNS cord-002490-kw8psrmz 72 7 of of IN cord-002490-kw8psrmz 72 8 GP GP NNP cord-002490-kw8psrmz 72 9 appear appear VBP cord-002490-kw8psrmz 72 10 to to TO cord-002490-kw8psrmz 72 11 fit fit VB cord-002490-kw8psrmz 72 12 well well RB cord-002490-kw8psrmz 72 13 within within IN cord-002490-kw8psrmz 72 14 the the DT cord-002490-kw8psrmz 72 15 cryo cryo NN cord-002490-kw8psrmz 72 16 - - HYPH cord-002490-kw8psrmz 72 17 EM EM NNP cord-002490-kw8psrmz 72 18 structure structure NN cord-002490-kw8psrmz 72 19 we -PRON- PRP cord-002490-kw8psrmz 72 20 report report VBP cord-002490-kw8psrmz 72 21 here here RB cord-002490-kw8psrmz 72 22 ( ( -LRB- cord-002490-kw8psrmz 72 23 Figs Figs NNP cord-002490-kw8psrmz 72 24 2 2 CD cord-002490-kw8psrmz 72 25 and and CC cord-002490-kw8psrmz 72 26 3 3 CD cord-002490-kw8psrmz 72 27 ) ) -RRB- cord-002490-kw8psrmz 72 28 and and CC cord-002490-kw8psrmz 72 29 the the DT cord-002490-kw8psrmz 72 30 resolution resolution NN cord-002490-kw8psrmz 72 31 , , , cord-002490-kw8psrmz 72 32 although although IN cord-002490-kw8psrmz 72 33 modest modest JJ cord-002490-kw8psrmz 72 34 ( ( -LRB- cord-002490-kw8psrmz 72 35 11 11 CD cord-002490-kw8psrmz 72 36 Å å NN cord-002490-kw8psrmz 72 37 ) ) -RRB- cord-002490-kw8psrmz 72 38 , , , cord-002490-kw8psrmz 72 39 is be VBZ cord-002490-kw8psrmz 72 40 an an DT cord-002490-kw8psrmz 72 41 improvement improvement NN cord-002490-kw8psrmz 72 42 compared compare VBN cord-002490-kw8psrmz 72 43 to to IN cord-002490-kw8psrmz 72 44 ~25 ~25 NNP cord-002490-kw8psrmz 72 45 Å å NN cord-002490-kw8psrmz 72 46 for for IN cord-002490-kw8psrmz 72 47 the the DT cord-002490-kw8psrmz 72 48 structures structure NNS cord-002490-kw8psrmz 72 49 generated generate VBN cord-002490-kw8psrmz 72 50 from from IN cord-002490-kw8psrmz 72 51 tomography tomography NN cord-002490-kw8psrmz 72 52 alone alone RB cord-002490-kw8psrmz 72 53 that that WDT cord-002490-kw8psrmz 72 54 appear appear VBP cord-002490-kw8psrmz 72 55 to to TO cord-002490-kw8psrmz 72 56 have have VB cord-002490-kw8psrmz 72 57 a a DT cord-002490-kw8psrmz 72 58 slightly slightly RB cord-002490-kw8psrmz 72 59 different different JJ cord-002490-kw8psrmz 72 60 shape shape NN cord-002490-kw8psrmz 72 61 ( ( -LRB- cord-002490-kw8psrmz 72 62 Fig Fig NNP cord-002490-kw8psrmz 72 63 . . . cord-002490-kw8psrmz 72 64 4 4 CD cord-002490-kw8psrmz 72 65 ) ) -RRB- cord-002490-kw8psrmz 72 66 . . . cord-002490-kw8psrmz 73 1 While while IN cord-002490-kw8psrmz 73 2 our -PRON- PRP$ cord-002490-kw8psrmz 73 3 structure structure NN cord-002490-kw8psrmz 73 4 shows show VBZ cord-002490-kw8psrmz 73 5 a a DT cord-002490-kw8psrmz 73 6 spike spike NN cord-002490-kw8psrmz 73 7 length length NN cord-002490-kw8psrmz 73 8 of of IN cord-002490-kw8psrmz 73 9 13 13 CD cord-002490-kw8psrmz 73 10 nm nm NN cord-002490-kw8psrmz 73 11 and and CC cord-002490-kw8psrmz 73 12 a a DT cord-002490-kw8psrmz 73 13 stalk stalk NN cord-002490-kw8psrmz 73 14 length length NN cord-002490-kw8psrmz 73 15 of of IN cord-002490-kw8psrmz 73 16 5 5 CD cord-002490-kw8psrmz 73 17 nm nm NN cord-002490-kw8psrmz 73 18 and and CC cord-002490-kw8psrmz 73 19 width width NN cord-002490-kw8psrmz 73 20 of of IN cord-002490-kw8psrmz 73 21 3.5 3.5 CD cord-002490-kw8psrmz 73 22 nm nm NN cord-002490-kw8psrmz 73 23 , , , cord-002490-kw8psrmz 73 24 the the DT cord-002490-kw8psrmz 73 25 tomographic tomographic JJ cord-002490-kw8psrmz 73 26 structures structure NNS cord-002490-kw8psrmz 73 27 show show VBP cord-002490-kw8psrmz 73 28 a a DT cord-002490-kw8psrmz 73 29 spike spike NN cord-002490-kw8psrmz 73 30 length length NN cord-002490-kw8psrmz 73 31 of of IN cord-002490-kw8psrmz 73 32 14 14 CD cord-002490-kw8psrmz 73 33 nm nm NN cord-002490-kw8psrmz 73 34 , , , cord-002490-kw8psrmz 73 35 with with IN cord-002490-kw8psrmz 73 36 a a DT cord-002490-kw8psrmz 73 37 more more RBR cord-002490-kw8psrmz 73 38 pinched pinch VBN cord-002490-kw8psrmz 73 39 , , , cord-002490-kw8psrmz 73 40 shorter short JJR cord-002490-kw8psrmz 73 41 and and CC cord-002490-kw8psrmz 73 42 more more RBR cord-002490-kw8psrmz 73 43 narrow narrow JJ cord-002490-kw8psrmz 73 44 stalk stalk NN cord-002490-kw8psrmz 73 45 region region NN cord-002490-kw8psrmz 73 46 of of IN cord-002490-kw8psrmz 73 47 2.5 2.5 CD cord-002490-kw8psrmz 73 48 nm nm NN cord-002490-kw8psrmz 73 49 in in IN cord-002490-kw8psrmz 73 50 length length NN cord-002490-kw8psrmz 73 51 and and CC cord-002490-kw8psrmz 73 52 3 3 CD cord-002490-kw8psrmz 73 53 nm nm NN cord-002490-kw8psrmz 73 54 width width NN cord-002490-kw8psrmz 73 55 , , , cord-002490-kw8psrmz 73 56 while while IN cord-002490-kw8psrmz 73 57 the the DT cord-002490-kw8psrmz 73 58 virion virion NN cord-002490-kw8psrmz 73 59 envelope envelope NN cord-002490-kw8psrmz 73 60 at at IN cord-002490-kw8psrmz 73 61 the the DT cord-002490-kw8psrmz 73 62 base base NN cord-002490-kw8psrmz 73 63 also also RB cord-002490-kw8psrmz 73 64 appears appear VBZ cord-002490-kw8psrmz 73 65 to to TO cord-002490-kw8psrmz 73 66 be be VB cord-002490-kw8psrmz 73 67 sloped slope VBN cord-002490-kw8psrmz 73 68 away away RB cord-002490-kw8psrmz 73 69 from from IN cord-002490-kw8psrmz 73 70 the the DT cord-002490-kw8psrmz 73 71 GP GP NNP cord-002490-kw8psrmz 73 72 stalk stalk NN cord-002490-kw8psrmz 73 73 ( ( -LRB- cord-002490-kw8psrmz 73 74 Fig Fig NNP cord-002490-kw8psrmz 73 75 . . . cord-002490-kw8psrmz 73 76 4 4 CD cord-002490-kw8psrmz 73 77 ) ) -RRB- cord-002490-kw8psrmz 73 78 . . . cord-002490-kw8psrmz 74 1 Our -PRON- PRP$ cord-002490-kw8psrmz 74 2 structure structure NN cord-002490-kw8psrmz 74 3 clearly clearly RB cord-002490-kw8psrmz 74 4 delineates delineate VBZ cord-002490-kw8psrmz 74 5 the the DT cord-002490-kw8psrmz 74 6 5 5 CD cord-002490-kw8psrmz 74 7 nm nm NN cord-002490-kw8psrmz 74 8 bilayer bilayer NN cord-002490-kw8psrmz 74 9 of of IN cord-002490-kw8psrmz 74 10 the the DT cord-002490-kw8psrmz 74 11 virion virion NN cord-002490-kw8psrmz 74 12 envelope envelope NN cord-002490-kw8psrmz 74 13 ( ( -LRB- cord-002490-kw8psrmz 74 14 that that DT cord-002490-kw8psrmz 74 15 has have VBZ cord-002490-kw8psrmz 74 16 an an DT cord-002490-kw8psrmz 74 17 internal internal JJ cord-002490-kw8psrmz 74 18 spacing spacing NN cord-002490-kw8psrmz 74 19 of of IN cord-002490-kw8psrmz 74 20 about about RB cord-002490-kw8psrmz 74 21 35 35 CD cord-002490-kw8psrmz 74 22 Å å NN cord-002490-kw8psrmz 74 23 , , , cord-002490-kw8psrmz 74 24 Fig Fig NNP cord-002490-kw8psrmz 74 25 . . NNP cord-002490-kw8psrmz 74 26 4a 4a CD cord-002490-kw8psrmz 74 27 ) ) -RRB- cord-002490-kw8psrmz 74 28 as as RB cord-002490-kw8psrmz 74 29 well well RB cord-002490-kw8psrmz 74 30 as as IN cord-002490-kw8psrmz 74 31 the the DT cord-002490-kw8psrmz 74 32 alpha alpha NN cord-002490-kw8psrmz 74 33 helices helix NNS cord-002490-kw8psrmz 74 34 of of IN cord-002490-kw8psrmz 74 35 the the DT cord-002490-kw8psrmz 74 36 heptad heptad NN cord-002490-kw8psrmz 74 37 repeat repeat NN cord-002490-kw8psrmz 74 38 domains domain NNS cord-002490-kw8psrmz 74 39 ( ( -LRB- cord-002490-kw8psrmz 74 40 that that WDT cord-002490-kw8psrmz 74 41 have have VBP cord-002490-kw8psrmz 74 42 a a DT cord-002490-kw8psrmz 74 43 diameter diameter NN cord-002490-kw8psrmz 74 44 of of IN cord-002490-kw8psrmz 74 45 about about RB cord-002490-kw8psrmz 74 46 12 12 CD cord-002490-kw8psrmz 74 47 Å å NN cord-002490-kw8psrmz 74 48 ) ) -RRB- cord-002490-kw8psrmz 74 49 and and CC cord-002490-kw8psrmz 74 50 the the DT cord-002490-kw8psrmz 74 51 nub nub NN cord-002490-kw8psrmz 74 52 feature feature NN cord-002490-kw8psrmz 74 53 at at IN cord-002490-kw8psrmz 74 54 the the DT cord-002490-kw8psrmz 74 55 base base NN cord-002490-kw8psrmz 74 56 of of IN cord-002490-kw8psrmz 74 57 the the DT cord-002490-kw8psrmz 74 58 propellers propeller NNS cord-002490-kw8psrmz 74 59 , , , cord-002490-kw8psrmz 74 60 whereas whereas IN cord-002490-kw8psrmz 74 61 these these DT cord-002490-kw8psrmz 74 62 features feature NNS cord-002490-kw8psrmz 74 63 were be VBD cord-002490-kw8psrmz 74 64 not not RB cord-002490-kw8psrmz 74 65 discernable discernable JJ cord-002490-kw8psrmz 74 66 in in IN cord-002490-kw8psrmz 74 67 the the DT cord-002490-kw8psrmz 74 68 previous previous JJ cord-002490-kw8psrmz 74 69 structures structure NNS cord-002490-kw8psrmz 74 70 28 28 CD cord-002490-kw8psrmz 74 71 , , , cord-002490-kw8psrmz 74 72 29 29 CD cord-002490-kw8psrmz 74 73 ( ( -LRB- cord-002490-kw8psrmz 74 74 Fig Fig NNP cord-002490-kw8psrmz 74 75 . . . cord-002490-kw8psrmz 74 76 4b 4b CD cord-002490-kw8psrmz 74 77 ) ) -RRB- cord-002490-kw8psrmz 74 78 . . . cord-002490-kw8psrmz 75 1 These these DT cord-002490-kw8psrmz 75 2 inconsistencies inconsistency NNS cord-002490-kw8psrmz 75 3 could could MD cord-002490-kw8psrmz 75 4 be be VB cord-002490-kw8psrmz 75 5 due due JJ cord-002490-kw8psrmz 75 6 to to IN cord-002490-kw8psrmz 75 7 the the DT cord-002490-kw8psrmz 75 8 differences difference NNS cord-002490-kw8psrmz 75 9 between between IN cord-002490-kw8psrmz 75 10 the the DT cord-002490-kw8psrmz 75 11 expressed expressed JJ cord-002490-kw8psrmz 75 12 and and CC cord-002490-kw8psrmz 75 13 viral viral JJ cord-002490-kw8psrmz 75 14 materials material NNS cord-002490-kw8psrmz 75 15 , , , cord-002490-kw8psrmz 75 16 the the DT cord-002490-kw8psrmz 75 17 latter latter JJ cord-002490-kw8psrmz 75 18 of of IN cord-002490-kw8psrmz 75 19 which which WDT cord-002490-kw8psrmz 75 20 was be VBD cord-002490-kw8psrmz 75 21 used use VBN cord-002490-kw8psrmz 75 22 in in IN cord-002490-kw8psrmz 75 23 the the DT cord-002490-kw8psrmz 75 24 present present JJ cord-002490-kw8psrmz 75 25 report report NN cord-002490-kw8psrmz 75 26 . . . cord-002490-kw8psrmz 76 1 Differences difference NNS cord-002490-kw8psrmz 76 2 in in IN cord-002490-kw8psrmz 76 3 the the DT cord-002490-kw8psrmz 76 4 methods method NNS cord-002490-kw8psrmz 76 5 used use VBN cord-002490-kw8psrmz 76 6 could could MD cord-002490-kw8psrmz 76 7 also also RB cord-002490-kw8psrmz 76 8 be be VB cord-002490-kw8psrmz 76 9 significant significant JJ cord-002490-kw8psrmz 76 10 , , , cord-002490-kw8psrmz 76 11 and and CC cord-002490-kw8psrmz 76 12 a a DT cord-002490-kw8psrmz 76 13 factor factor NN cord-002490-kw8psrmz 76 14 in in IN cord-002490-kw8psrmz 76 15 the the DT cord-002490-kw8psrmz 76 16 improved improved JJ cord-002490-kw8psrmz 76 17 resolution resolution NN cord-002490-kw8psrmz 76 18 was be VBD cord-002490-kw8psrmz 76 19 the the DT cord-002490-kw8psrmz 76 20 use use NN cord-002490-kw8psrmz 76 21 of of IN cord-002490-kw8psrmz 76 22 an an DT cord-002490-kw8psrmz 76 23 optimally optimally RB cord-002490-kw8psrmz 76 24 sized sized JJ cord-002490-kw8psrmz 76 25 T t NN cord-002490-kw8psrmz 76 26 - - HYPH cord-002490-kw8psrmz 76 27 shaped shape VBN cord-002490-kw8psrmz 76 28 mask mask NN cord-002490-kw8psrmz 76 29 , , , cord-002490-kw8psrmz 76 30 and and CC cord-002490-kw8psrmz 76 31 the the DT cord-002490-kw8psrmz 76 32 selection selection NN cord-002490-kw8psrmz 76 33 of of IN cord-002490-kw8psrmz 76 34 straight straight JJ cord-002490-kw8psrmz 76 35 regions region NNS cord-002490-kw8psrmz 76 36 of of IN cord-002490-kw8psrmz 76 37 the the DT cord-002490-kw8psrmz 76 38 virion virion NN cord-002490-kw8psrmz 76 39 membrane membrane NN cord-002490-kw8psrmz 76 40 for for IN cord-002490-kw8psrmz 76 41 analysis analysis NN cord-002490-kw8psrmz 76 42 ( ( -LRB- cord-002490-kw8psrmz 76 43 Supplementary Supplementary NNP cord-002490-kw8psrmz 76 44 Figure Figure NNP cord-002490-kw8psrmz 76 45 S3 S3 NNP cord-002490-kw8psrmz 76 46 ) ) -RRB- cord-002490-kw8psrmz 76 47 . . . cord-002490-kw8psrmz 77 1 This this DT cord-002490-kw8psrmz 77 2 allowed allow VBD cord-002490-kw8psrmz 77 3 accurate accurate JJ cord-002490-kw8psrmz 77 4 alignment alignment NN cord-002490-kw8psrmz 77 5 and and CC cord-002490-kw8psrmz 77 6 selection selection NN cord-002490-kw8psrmz 77 7 of of IN cord-002490-kw8psrmz 77 8 images image NNS cord-002490-kw8psrmz 77 9 taken take VBN cord-002490-kw8psrmz 77 10 at at IN cord-002490-kw8psrmz 77 11 right right NN cord-002490-kw8psrmz 77 12 - - HYPH cord-002490-kw8psrmz 77 13 angles angle NNS cord-002490-kw8psrmz 77 14 to to IN cord-002490-kw8psrmz 77 15 the the DT cord-002490-kw8psrmz 77 16 three three CD cord-002490-kw8psrmz 77 17 - - HYPH cord-002490-kw8psrmz 77 18 fold fold JJ cord-002490-kw8psrmz 77 19 axis axis NN cord-002490-kw8psrmz 77 20 of of IN cord-002490-kw8psrmz 77 21 the the DT cord-002490-kw8psrmz 77 22 spikes spike NNS cord-002490-kw8psrmz 77 23 , , , cord-002490-kw8psrmz 77 24 while while IN cord-002490-kw8psrmz 77 25 getting get VBG cord-002490-kw8psrmz 77 26 an an DT cord-002490-kw8psrmz 77 27 excellent excellent JJ cord-002490-kw8psrmz 77 28 coverage coverage NN cord-002490-kw8psrmz 77 29 of of IN cord-002490-kw8psrmz 77 30 side side NN cord-002490-kw8psrmz 77 31 views view NNS cord-002490-kw8psrmz 77 32 , , , cord-002490-kw8psrmz 77 33 since since IN cord-002490-kw8psrmz 77 34 the the DT cord-002490-kw8psrmz 77 35 spikes spike NNS cord-002490-kw8psrmz 77 36 are be VBP cord-002490-kw8psrmz 77 37 randomly randomly RB cord-002490-kw8psrmz 77 38 distributed distribute VBN cord-002490-kw8psrmz 77 39 on on IN cord-002490-kw8psrmz 77 40 their -PRON- PRP$ cord-002490-kw8psrmz 77 41 3-fold 3-fold CD cord-002490-kw8psrmz 77 42 axes axis NNS cord-002490-kw8psrmz 77 43 , , , cord-002490-kw8psrmz 77 44 using use VBG cord-002490-kw8psrmz 77 45 Euler Euler NNP cord-002490-kw8psrmz 77 46 angles angle NNS cord-002490-kw8psrmz 77 47 of of IN cord-002490-kw8psrmz 77 48 0 0 CD cord-002490-kw8psrmz 77 49 - - SYM cord-002490-kw8psrmz 77 50 120 120 CD cord-002490-kw8psrmz 77 51 degrees degree NNS cord-002490-kw8psrmz 77 52 of of IN cord-002490-kw8psrmz 77 53 rotation rotation NN cord-002490-kw8psrmz 77 54 around around IN cord-002490-kw8psrmz 77 55 the the DT cord-002490-kw8psrmz 77 56 Z z NN cord-002490-kw8psrmz 77 57 - - HYPH cord-002490-kw8psrmz 77 58 axis axis NN cord-002490-kw8psrmz 77 59 ( ( -LRB- cord-002490-kw8psrmz 77 60 since since IN cord-002490-kw8psrmz 77 61 it -PRON- PRP cord-002490-kw8psrmz 77 62 is be VBZ cord-002490-kw8psrmz 77 63 a a DT cord-002490-kw8psrmz 77 64 trimer trimer NN cord-002490-kw8psrmz 77 65 ) ) -RRB- cord-002490-kw8psrmz 77 66 . . . cord-002490-kw8psrmz 78 1 Thus thus RB cord-002490-kw8psrmz 78 2 , , , cord-002490-kw8psrmz 78 3 we -PRON- PRP cord-002490-kw8psrmz 78 4 avoided avoid VBD cord-002490-kw8psrmz 78 5 the the DT cord-002490-kw8psrmz 78 6 " " `` cord-002490-kw8psrmz 78 7 missing miss VBG cord-002490-kw8psrmz 78 8 wedge wedge NN cord-002490-kw8psrmz 78 9 " " '' cord-002490-kw8psrmz 78 10 of of IN cord-002490-kw8psrmz 78 11 information information NN cord-002490-kw8psrmz 78 12 associated associate VBN cord-002490-kw8psrmz 78 13 with with IN cord-002490-kw8psrmz 78 14 tomography tomography NN cord-002490-kw8psrmz 78 15 , , , cord-002490-kw8psrmz 78 16 where where WRB cord-002490-kw8psrmz 78 17 the the DT cord-002490-kw8psrmz 78 18 constraint constraint NN cord-002490-kw8psrmz 78 19 of of IN cord-002490-kw8psrmz 78 20 tilt tilt NN cord-002490-kw8psrmz 78 21 angle angle NN cord-002490-kw8psrmz 78 22 limits limit VBZ cord-002490-kw8psrmz 78 23 the the DT cord-002490-kw8psrmz 78 24 angular angular JJ cord-002490-kw8psrmz 78 25 distribution distribution NN cord-002490-kw8psrmz 78 26 of of IN cord-002490-kw8psrmz 78 27 views view NNS cord-002490-kw8psrmz 78 28 . . . cord-002490-kw8psrmz 79 1 Our -PRON- PRP$ cord-002490-kw8psrmz 79 2 analyses analysis NNS cord-002490-kw8psrmz 79 3 did do VBD cord-002490-kw8psrmz 79 4 not not RB cord-002490-kw8psrmz 79 5 reveal reveal VB cord-002490-kw8psrmz 79 6 any any DT cord-002490-kw8psrmz 79 7 longitudinal longitudinal JJ cord-002490-kw8psrmz 79 8 symmetry symmetry NN cord-002490-kw8psrmz 79 9 or or CC cord-002490-kw8psrmz 79 10 well well RB cord-002490-kw8psrmz 79 11 - - HYPH cord-002490-kw8psrmz 79 12 ordered order VBN cord-002490-kw8psrmz 79 13 periodicity periodicity NN cord-002490-kw8psrmz 79 14 of of IN cord-002490-kw8psrmz 79 15 the the DT cord-002490-kw8psrmz 79 16 GP gp NN cord-002490-kw8psrmz 79 17 spikes spike NNS cord-002490-kw8psrmz 79 18 along along IN cord-002490-kw8psrmz 79 19 the the DT cord-002490-kw8psrmz 79 20 axis axis NN cord-002490-kw8psrmz 79 21 of of IN cord-002490-kw8psrmz 79 22 the the DT cord-002490-kw8psrmz 79 23 virion virion NN cord-002490-kw8psrmz 79 24 filament filament NN cord-002490-kw8psrmz 79 25 , , , cord-002490-kw8psrmz 79 26 showing show VBG cord-002490-kw8psrmz 79 27 that that IN cord-002490-kw8psrmz 79 28 the the DT cord-002490-kw8psrmz 79 29 spike spike NN cord-002490-kw8psrmz 79 30 arrangement arrangement NN cord-002490-kw8psrmz 79 31 of of IN cord-002490-kw8psrmz 79 32 virions virion NNS cord-002490-kw8psrmz 79 33 may may MD cord-002490-kw8psrmz 79 34 not not RB cord-002490-kw8psrmz 79 35 follow follow VB cord-002490-kw8psrmz 79 36 a a DT cord-002490-kw8psrmz 79 37 rigid rigid JJ cord-002490-kw8psrmz 79 38 symmetry symmetry NN cord-002490-kw8psrmz 79 39 . . . cord-002490-kw8psrmz 80 1 Nor nor CC cord-002490-kw8psrmz 80 2 was be VBD cord-002490-kw8psrmz 80 3 any any DT cord-002490-kw8psrmz 80 4 longitudinal longitudinal JJ cord-002490-kw8psrmz 80 5 symmetry symmetry NN cord-002490-kw8psrmz 80 6 apparent apparent JJ cord-002490-kw8psrmz 80 7 in in IN cord-002490-kw8psrmz 80 8 the the DT cord-002490-kw8psrmz 80 9 virion virion NN cord-002490-kw8psrmz 80 10 VP40 VP40 NNP cord-002490-kw8psrmz 80 11 matrix matrix NN cord-002490-kw8psrmz 80 12 layer layer NN cord-002490-kw8psrmz 80 13 ( ( -LRB- cord-002490-kw8psrmz 80 14 although although IN cord-002490-kw8psrmz 80 15 a a DT cord-002490-kw8psrmz 80 16 5 5 CD cord-002490-kw8psrmz 80 17 nm nm NN cord-002490-kw8psrmz 80 18 lattice lattice NN cord-002490-kw8psrmz 80 19 spacing spacing NN cord-002490-kw8psrmz 80 20 in in IN cord-002490-kw8psrmz 80 21 the the DT cord-002490-kw8psrmz 80 22 VP40 VP40 NNP cord-002490-kw8psrmz 80 23 layer layer NN cord-002490-kw8psrmz 80 24 has have VBZ cord-002490-kw8psrmz 80 25 been be VBN cord-002490-kw8psrmz 80 26 observed observe VBN cord-002490-kw8psrmz 80 27 in in IN cord-002490-kw8psrmz 80 28 images image NNS cord-002490-kw8psrmz 80 29 showing show VBG cord-002490-kw8psrmz 80 30 a a DT cord-002490-kw8psrmz 80 31 perpendicular perpendicular JJ cord-002490-kw8psrmz 80 32 view view NN cord-002490-kw8psrmz 80 33 of of IN cord-002490-kw8psrmz 80 34 the the DT cord-002490-kw8psrmz 80 35 VLP VLP NNP cord-002490-kw8psrmz 80 36 membrane membrane NN cord-002490-kw8psrmz 80 37 4 4 CD cord-002490-kw8psrmz 80 38 ) ) -RRB- cord-002490-kw8psrmz 80 39 . . . cord-002490-kw8psrmz 81 1 We -PRON- PRP cord-002490-kw8psrmz 81 2 have have VBP cord-002490-kw8psrmz 81 3 shown show VBN cord-002490-kw8psrmz 81 4 that that IN cord-002490-kw8psrmz 81 5 the the DT cord-002490-kw8psrmz 81 6 GP gp NN cord-002490-kw8psrmz 81 7 spikes spike NNS cord-002490-kw8psrmz 81 8 of of IN cord-002490-kw8psrmz 81 9 EBOV EBOV NNP cord-002490-kw8psrmz 81 10 virions virion NNS cord-002490-kw8psrmz 81 11 likely likely RB cord-002490-kw8psrmz 81 12 have have VBP cord-002490-kw8psrmz 81 13 an an DT cord-002490-kw8psrmz 81 14 inconsistent inconsistent JJ cord-002490-kw8psrmz 81 15 or or CC cord-002490-kw8psrmz 81 16 variable variable JJ cord-002490-kw8psrmz 81 17 spacing spacing NN cord-002490-kw8psrmz 81 18 , , , cord-002490-kw8psrmz 81 19 similar similar JJ cord-002490-kw8psrmz 81 20 to to IN cord-002490-kw8psrmz 81 21 that that DT cord-002490-kw8psrmz 81 22 previously previously RB cord-002490-kw8psrmz 81 23 shown show VBN cord-002490-kw8psrmz 81 24 for for IN cord-002490-kw8psrmz 81 25 EBOV EBOV NNP cord-002490-kw8psrmz 81 26 VLPs vlp NNS cord-002490-kw8psrmz 81 27 ( ( -LRB- cord-002490-kw8psrmz 81 28 Supplementary supplementary JJ cord-002490-kw8psrmz 81 29 Fig Fig NNP cord-002490-kw8psrmz 81 30 S3 S3 NNP cord-002490-kw8psrmz 81 31 ) ) -RRB- cord-002490-kw8psrmz 81 32 . . . cord-002490-kw8psrmz 82 1 We -PRON- PRP cord-002490-kw8psrmz 82 2 also also RB cord-002490-kw8psrmz 82 3 confirmed confirm VBD cord-002490-kw8psrmz 82 4 previous previous JJ cord-002490-kw8psrmz 82 5 results result NNS cord-002490-kw8psrmz 82 6 4 4 CD cord-002490-kw8psrmz 82 7 showing show VBG cord-002490-kw8psrmz 82 8 that that IN cord-002490-kw8psrmz 82 9 the the DT cord-002490-kw8psrmz 82 10 nucleocapsid nucleocapsid NNP cord-002490-kw8psrmz 82 11 layer layer NN cord-002490-kw8psrmz 82 12 of of IN cord-002490-kw8psrmz 82 13 virions virion NNS cord-002490-kw8psrmz 82 14 maintains maintain VBZ cord-002490-kw8psrmz 82 15 a a DT cord-002490-kw8psrmz 82 16 consistent consistent JJ cord-002490-kw8psrmz 82 17 ordered order VBN cord-002490-kw8psrmz 82 18 longitudinal longitudinal JJ cord-002490-kw8psrmz 82 19 spacing spacing NN cord-002490-kw8psrmz 82 20 of of IN cord-002490-kw8psrmz 82 21 about about RB cord-002490-kw8psrmz 82 22 7 7 CD cord-002490-kw8psrmz 82 23 nm nm NN cord-002490-kw8psrmz 82 24 ( ( -LRB- cord-002490-kw8psrmz 82 25 Supplementary Supplementary NNP cord-002490-kw8psrmz 82 26 Fig Fig NNP cord-002490-kw8psrmz 82 27 S3 S3 NNP cord-002490-kw8psrmz 82 28 ) ) -RRB- cord-002490-kw8psrmz 82 29 , , , cord-002490-kw8psrmz 82 30 despite despite IN cord-002490-kw8psrmz 82 31 the the DT cord-002490-kw8psrmz 82 32 curves curve NNS cord-002490-kw8psrmz 82 33 and and CC cord-002490-kw8psrmz 82 34 bends bend NNS cord-002490-kw8psrmz 82 35 of of IN cord-002490-kw8psrmz 82 36 the the DT cord-002490-kw8psrmz 82 37 filament filament NN cord-002490-kw8psrmz 82 38 . . . cord-002490-kw8psrmz 83 1 Thus thus RB cord-002490-kw8psrmz 83 2 any any DT cord-002490-kw8psrmz 83 3 contacts contact NNS cord-002490-kw8psrmz 83 4 between between IN cord-002490-kw8psrmz 83 5 GP GP NNP cord-002490-kw8psrmz 83 6 and and CC cord-002490-kw8psrmz 83 7 VP40 VP40 NNP cord-002490-kw8psrmz 83 8 and/or and/or CC cord-002490-kw8psrmz 83 9 the the DT cord-002490-kw8psrmz 83 10 nucleocapsid nucleocapsid NN cord-002490-kw8psrmz 83 11 proteins protein NNS cord-002490-kw8psrmz 83 12 may may MD cord-002490-kw8psrmz 83 13 be be VB cord-002490-kw8psrmz 83 14 variable variable JJ cord-002490-kw8psrmz 83 15 and and CC cord-002490-kw8psrmz 83 16 non non JJ cord-002490-kw8psrmz 83 17 - - JJ cord-002490-kw8psrmz 83 18 equivalent equivalent JJ cord-002490-kw8psrmz 83 19 : : : cord-002490-kw8psrmz 83 20 or or CC cord-002490-kw8psrmz 83 21 if if IN cord-002490-kw8psrmz 83 22 a a DT cord-002490-kw8psrmz 83 23 preferred preferred JJ cord-002490-kw8psrmz 83 24 alignment alignment NN cord-002490-kw8psrmz 83 25 and and CC cord-002490-kw8psrmz 83 26 stoichiometry stoichiometry NN cord-002490-kw8psrmz 83 27 exists exist VBZ cord-002490-kw8psrmz 83 28 , , , cord-002490-kw8psrmz 83 29 it -PRON- PRP cord-002490-kw8psrmz 83 30 was be VBD cord-002490-kw8psrmz 83 31 not not RB cord-002490-kw8psrmz 83 32 detectable detectable JJ cord-002490-kw8psrmz 83 33 by by IN cord-002490-kw8psrmz 83 34 cryo cryo NN cord-002490-kw8psrmz 83 35 - - HYPH cord-002490-kw8psrmz 83 36 EM em NN cord-002490-kw8psrmz 83 37 of of IN cord-002490-kw8psrmz 83 38 whole whole JJ cord-002490-kw8psrmz 83 39 virions virion NNS cord-002490-kw8psrmz 83 40 with with IN cord-002490-kw8psrmz 83 41 our -PRON- PRP$ cord-002490-kw8psrmz 83 42 current current JJ cord-002490-kw8psrmz 83 43 data datum NNS cord-002490-kw8psrmz 83 44 . . . cord-002490-kw8psrmz 84 1 In in IN cord-002490-kw8psrmz 84 2 conclusion conclusion NN cord-002490-kw8psrmz 84 3 , , , cord-002490-kw8psrmz 84 4 the the DT cord-002490-kw8psrmz 84 5 current current JJ cord-002490-kw8psrmz 84 6 structure structure NN cord-002490-kw8psrmz 84 7 is be VBZ cord-002490-kw8psrmz 84 8 consistent consistent JJ cord-002490-kw8psrmz 84 9 with with IN cord-002490-kw8psrmz 84 10 the the DT cord-002490-kw8psrmz 84 11 mucin mucin NN cord-002490-kw8psrmz 84 12 - - HYPH cord-002490-kw8psrmz 84 13 like like JJ cord-002490-kw8psrmz 84 14 domain domain NN cord-002490-kw8psrmz 84 15 occluding occlude VBG cord-002490-kw8psrmz 84 16 the the DT cord-002490-kw8psrmz 84 17 glycan glycan NN cord-002490-kw8psrmz 84 18 cap cap NN cord-002490-kw8psrmz 84 19 and and CC cord-002490-kw8psrmz 84 20 receptor receptor NN cord-002490-kw8psrmz 84 21 - - HYPH cord-002490-kw8psrmz 84 22 binding bind VBG cord-002490-kw8psrmz 84 23 region region NN cord-002490-kw8psrmz 84 24 , , , cord-002490-kw8psrmz 84 25 such such JJ cord-002490-kw8psrmz 84 26 that that IN cord-002490-kw8psrmz 84 27 cleavage cleavage NN cord-002490-kw8psrmz 84 28 is be VBZ cord-002490-kw8psrmz 84 29 required require VBN cord-002490-kw8psrmz 84 30 for for IN cord-002490-kw8psrmz 84 31 the the DT cord-002490-kw8psrmz 84 32 functioning functioning NN cord-002490-kw8psrmz 84 33 of of IN cord-002490-kw8psrmz 84 34 the the DT cord-002490-kw8psrmz 84 35 latter latter JJ cord-002490-kw8psrmz 84 36 in in IN cord-002490-kw8psrmz 84 37 the the DT cord-002490-kw8psrmz 84 38 endosome endosome NN cord-002490-kw8psrmz 84 39 to to TO cord-002490-kw8psrmz 84 40 reveal reveal VB cord-002490-kw8psrmz 84 41 the the DT cord-002490-kw8psrmz 84 42 receptor receptor NN cord-002490-kw8psrmz 84 43 binding bind VBG cord-002490-kw8psrmz 84 44 site site NN cord-002490-kw8psrmz 84 45 on on IN cord-002490-kw8psrmz 84 46 GP1 GP1 NNP cord-002490-kw8psrmz 84 47 13 13 CD cord-002490-kw8psrmz 84 48 , , , cord-002490-kw8psrmz 84 49 17 17 CD cord-002490-kw8psrmz 84 50 , , , cord-002490-kw8psrmz 84 51 [ [ -LRB- cord-002490-kw8psrmz 84 52 20 20 CD cord-002490-kw8psrmz 84 53 ] ] -RRB- cord-002490-kw8psrmz 84 54 [ [ -LRB- cord-002490-kw8psrmz 84 55 21 21 CD cord-002490-kw8psrmz 84 56 ] ] -RRB- cord-002490-kw8psrmz 84 57 [ [ -LRB- cord-002490-kw8psrmz 84 58 22 22 CD cord-002490-kw8psrmz 84 59 ] ] -RRB- cord-002490-kw8psrmz 84 60 . . . cord-002490-kw8psrmz 85 1 It -PRON- PRP cord-002490-kw8psrmz 85 2 is be VBZ cord-002490-kw8psrmz 85 3 likely likely JJ cord-002490-kw8psrmz 85 4 that that IN cord-002490-kw8psrmz 85 5 the the DT cord-002490-kw8psrmz 85 6 cleavage cleavage NN cord-002490-kw8psrmz 85 7 of of IN cord-002490-kw8psrmz 85 8 the the DT cord-002490-kw8psrmz 85 9 glycan glycan NN cord-002490-kw8psrmz 85 10 cap cap NN cord-002490-kw8psrmz 85 11 also also RB cord-002490-kw8psrmz 85 12 includes include VBZ cord-002490-kw8psrmz 85 13 removal removal NN cord-002490-kw8psrmz 85 14 of of IN cord-002490-kw8psrmz 85 15 both both CC cord-002490-kw8psrmz 85 16 the the DT cord-002490-kw8psrmz 85 17 " " `` cord-002490-kw8psrmz 85 18 propeller propeller NN cord-002490-kw8psrmz 85 19 " " '' cord-002490-kw8psrmz 85 20 and and CC cord-002490-kw8psrmz 85 21 " " `` cord-002490-kw8psrmz 85 22 nub nub NN cord-002490-kw8psrmz 85 23 " " '' cord-002490-kw8psrmz 85 24 structures structure NNS cord-002490-kw8psrmz 85 25 described describe VBN cord-002490-kw8psrmz 85 26 here here RB cord-002490-kw8psrmz 85 27 . . . cord-002490-kw8psrmz 86 1 It -PRON- PRP cord-002490-kw8psrmz 86 2 is be VBZ cord-002490-kw8psrmz 86 3 clear clear JJ cord-002490-kw8psrmz 86 4 that that IN cord-002490-kw8psrmz 86 5 the the DT cord-002490-kw8psrmz 86 6 density density NN cord-002490-kw8psrmz 86 7 in in IN cord-002490-kw8psrmz 86 8 our -PRON- PRP$ cord-002490-kw8psrmz 86 9 structure structure NN cord-002490-kw8psrmz 86 10 partially partially RB cord-002490-kw8psrmz 86 11 covers cover VBZ cord-002490-kw8psrmz 86 12 the the DT cord-002490-kw8psrmz 86 13 receptor receptor NN cord-002490-kw8psrmz 86 14 binding bind VBG cord-002490-kw8psrmz 86 15 domain domain NN cord-002490-kw8psrmz 86 16 , , , cord-002490-kw8psrmz 86 17 and and CC cord-002490-kw8psrmz 86 18 would would MD cord-002490-kw8psrmz 86 19 likely likely RB cord-002490-kw8psrmz 86 20 inhibit inhibit VB cord-002490-kw8psrmz 86 21 NPC-1 NPC-1 NNP cord-002490-kw8psrmz 86 22 binding bind VBG cord-002490-kw8psrmz 86 23 until until IN cord-002490-kw8psrmz 86 24 cleavage cleavage NN cord-002490-kw8psrmz 86 25 of of IN cord-002490-kw8psrmz 86 26 the the DT cord-002490-kw8psrmz 86 27 mucin mucin NN cord-002490-kw8psrmz 86 28 - - HYPH cord-002490-kw8psrmz 86 29 like like JJ cord-002490-kw8psrmz 86 30 domain domain NN cord-002490-kw8psrmz 86 31 occurs occur VBZ cord-002490-kw8psrmz 86 32 . . . cord-002490-kw8psrmz 87 1 Further further JJ cord-002490-kw8psrmz 87 2 high high JJ cord-002490-kw8psrmz 87 3 resolution resolution NN cord-002490-kw8psrmz 87 4 studies study NNS cord-002490-kw8psrmz 87 5 of of IN cord-002490-kw8psrmz 87 6 the the DT cord-002490-kw8psrmz 87 7 viral viral RB cord-002490-kw8psrmz 87 8 - - HYPH cord-002490-kw8psrmz 87 9 derived derive VBN cord-002490-kw8psrmz 87 10 GP gp NN cord-002490-kw8psrmz 87 11 structure structure NN cord-002490-kw8psrmz 87 12 and and CC cord-002490-kw8psrmz 87 13 virion virion NN cord-002490-kw8psrmz 87 14 particles particle NNS cord-002490-kw8psrmz 87 15 are be VBP cord-002490-kw8psrmz 87 16 needed need VBN cord-002490-kw8psrmz 87 17 to to TO cord-002490-kw8psrmz 87 18 answer answer VB cord-002490-kw8psrmz 87 19 these these DT cord-002490-kw8psrmz 87 20 questions question NNS cord-002490-kw8psrmz 87 21 , , , cord-002490-kw8psrmz 87 22 and and CC cord-002490-kw8psrmz 87 23 for for IN cord-002490-kw8psrmz 87 24 progressing progress VBG cord-002490-kw8psrmz 87 25 knowledge knowledge NN cord-002490-kw8psrmz 87 26 of of IN cord-002490-kw8psrmz 87 27 EBOV EBOV NNP cord-002490-kw8psrmz 87 28 morphogenesis morphogenesis NN cord-002490-kw8psrmz 87 29 . . . cord-002490-kw8psrmz 88 1 In in IN cord-002490-kw8psrmz 88 2 future future JJ cord-002490-kw8psrmz 88 3 studies study NNS cord-002490-kw8psrmz 88 4 , , , cord-002490-kw8psrmz 88 5 analyses analysis NNS cord-002490-kw8psrmz 88 6 of of IN cord-002490-kw8psrmz 88 7 the the DT cord-002490-kw8psrmz 88 8 spatial spatial JJ cord-002490-kw8psrmz 88 9 arrangement arrangement NN cord-002490-kw8psrmz 88 10 of of IN cord-002490-kw8psrmz 88 11 the the DT cord-002490-kw8psrmz 88 12 spikes spike NNS cord-002490-kw8psrmz 88 13 in in IN cord-002490-kw8psrmz 88 14 the the DT cord-002490-kw8psrmz 88 15 membrane membrane NN cord-002490-kw8psrmz 88 16 , , , cord-002490-kw8psrmz 88 17 the the DT cord-002490-kw8psrmz 88 18 structural structural JJ cord-002490-kw8psrmz 88 19 arrangement arrangement NN cord-002490-kw8psrmz 88 20 of of IN cord-002490-kw8psrmz 88 21 the the DT cord-002490-kw8psrmz 88 22 transmembrane transmembrane NN cord-002490-kw8psrmz 88 23 and and CC cord-002490-kw8psrmz 88 24 cytoplasmic cytoplasmic JJ cord-002490-kw8psrmz 88 25 domains domain NNS cord-002490-kw8psrmz 88 26 , , , cord-002490-kw8psrmz 88 27 and and CC cord-002490-kw8psrmz 88 28 analysis analysis NN cord-002490-kw8psrmz 88 29 of of IN cord-002490-kw8psrmz 88 30 flexible flexible JJ cord-002490-kw8psrmz 88 31 , , , cord-002490-kw8psrmz 88 32 quasi quasi JJ cord-002490-kw8psrmz 88 33 - - JJ cord-002490-kw8psrmz 88 34 equivalent equivalent JJ cord-002490-kw8psrmz 88 35 connections connection NNS cord-002490-kw8psrmz 88 36 between between IN cord-002490-kw8psrmz 88 37 the the DT cord-002490-kw8psrmz 88 38 envelope envelope NN cord-002490-kw8psrmz 88 39 matrix matrix NN cord-002490-kw8psrmz 88 40 protein protein NN cord-002490-kw8psrmz 88 41 VP40 VP40 NNP cord-002490-kw8psrmz 88 42 and and CC cord-002490-kw8psrmz 88 43 the the DT cord-002490-kw8psrmz 88 44 nucleocapsid nucleocapsid NN cord-002490-kw8psrmz 88 45 , , , cord-002490-kw8psrmz 88 46 will will MD cord-002490-kw8psrmz 88 47 all all DT cord-002490-kw8psrmz 88 48 be be VB cord-002490-kw8psrmz 88 49 important important JJ cord-002490-kw8psrmz 88 50 to to TO cord-002490-kw8psrmz 88 51 further further VB cord-002490-kw8psrmz 88 52 our -PRON- PRP$ cord-002490-kw8psrmz 88 53 understanding understanding NN cord-002490-kw8psrmz 88 54 of of IN cord-002490-kw8psrmz 88 55 how how WRB cord-002490-kw8psrmz 88 56 these these DT cord-002490-kw8psrmz 88 57 viral viral JJ cord-002490-kw8psrmz 88 58 components component NNS cord-002490-kw8psrmz 88 59 function function VBP cord-002490-kw8psrmz 88 60 in in IN cord-002490-kw8psrmz 88 61 the the DT cord-002490-kw8psrmz 88 62 replication replication NN cord-002490-kw8psrmz 88 63 cycle cycle NN cord-002490-kw8psrmz 88 64 of of IN cord-002490-kw8psrmz 88 65 EBOV EBOV NNP cord-002490-kw8psrmz 88 66 . . . cord-002490-kw8psrmz 89 1 Scientific Scientific NNP cord-002490-kw8psrmz 89 2 RepoRts RepoRts NNP cord-002490-kw8psrmz 89 3 | | . cord-002490-kw8psrmz 90 1 7:46374 7:46374 LS cord-002490-kw8psrmz 90 2 | | XX cord-002490-kw8psrmz 91 1 DOI DOI NNP cord-002490-kw8psrmz 91 2 : : : cord-002490-kw8psrmz 92 1 10.1038 10.1038 CD cord-002490-kw8psrmz 92 2 / / SYM cord-002490-kw8psrmz 92 3 srep46374 srep46374 NNP cord-002490-kw8psrmz 92 4 Methods Methods NNPS cord-002490-kw8psrmz 92 5 Cells cell NNS cord-002490-kw8psrmz 92 6 and and CC cord-002490-kw8psrmz 92 7 viruses virus NNS cord-002490-kw8psrmz 92 8 . . . cord-002490-kw8psrmz 93 1 Zaire Zaire NNP cord-002490-kw8psrmz 93 2 Ebola Ebola NNP cord-002490-kw8psrmz 93 3 virus virus NN cord-002490-kw8psrmz 93 4 ( ( -LRB- cord-002490-kw8psrmz 93 5 Mayinga Mayinga NNP cord-002490-kw8psrmz 93 6 strain strain NN cord-002490-kw8psrmz 93 7 ) ) -RRB- cord-002490-kw8psrmz 93 8 was be VBD cord-002490-kw8psrmz 93 9 produced produce VBN cord-002490-kw8psrmz 93 10 in in IN cord-002490-kw8psrmz 93 11 Vero Vero NNP cord-002490-kw8psrmz 93 12 ( ( -LRB- cord-002490-kw8psrmz 93 13 E6 e6 NN cord-002490-kw8psrmz 93 14 ) ) -RRB- cord-002490-kw8psrmz 93 15 culture culture NN cord-002490-kw8psrmz 93 16 and and CC cord-002490-kw8psrmz 93 17 purified purify VBN cord-002490-kw8psrmz 93 18 and and CC cord-002490-kw8psrmz 93 19 concentrated concentrate VBN cord-002490-kw8psrmz 93 20 by by IN cord-002490-kw8psrmz 93 21 centrifugation centrifugation NN cord-002490-kw8psrmz 93 22 37 37 CD cord-002490-kw8psrmz 93 23 . . . cord-002490-kw8psrmz 94 1 Viral viral JJ cord-002490-kw8psrmz 94 2 preparations preparation NNS cord-002490-kw8psrmz 94 3 were be VBD cord-002490-kw8psrmz 94 4 characterised characterise VBN cord-002490-kw8psrmz 94 5 using use VBG cord-002490-kw8psrmz 94 6 polyacryalamide polyacryalamide NNP cord-002490-kw8psrmz 94 7 gel gel NN cord-002490-kw8psrmz 94 8 electropheresis electropheresis NN cord-002490-kw8psrmz 94 9 and and CC cord-002490-kw8psrmz 94 10 Western western JJ cord-002490-kw8psrmz 94 11 blotting blotting NN cord-002490-kw8psrmz 94 12 . . . cord-002490-kw8psrmz 95 1 Samples sample NNS cord-002490-kw8psrmz 95 2 were be VBD cord-002490-kw8psrmz 95 3 inactivated inactivate VBN cord-002490-kw8psrmz 95 4 by by IN cord-002490-kw8psrmz 95 5 using use VBG cord-002490-kw8psrmz 95 6 paraformaldehyde paraformaldehyde JJ cord-002490-kw8psrmz 95 7 fixation fixation NN cord-002490-kw8psrmz 95 8 ( ( -LRB- cord-002490-kw8psrmz 95 9 4 4 CD cord-002490-kw8psrmz 95 10 % % NN cord-002490-kw8psrmz 95 11 ) ) -RRB- cord-002490-kw8psrmz 95 12 followed follow VBN cord-002490-kw8psrmz 95 13 by by IN cord-002490-kw8psrmz 95 14 dialysis dialysis NN cord-002490-kw8psrmz 95 15 against against IN cord-002490-kw8psrmz 95 16 PBS PBS NNP cord-002490-kw8psrmz 95 17 to to TO cord-002490-kw8psrmz 95 18 remove remove VB cord-002490-kw8psrmz 95 19 the the DT cord-002490-kw8psrmz 95 20 excess excess NN cord-002490-kw8psrmz 95 21 . . . cord-002490-kw8psrmz 96 1 Dialysis dialysis NN cord-002490-kw8psrmz 96 2 was be VBD cord-002490-kw8psrmz 96 3 carried carry VBN cord-002490-kw8psrmz 96 4 out out RP cord-002490-kw8psrmz 96 5 using use VBG cord-002490-kw8psrmz 96 6 a a DT cord-002490-kw8psrmz 96 7 0.5 0.5 CD cord-002490-kw8psrmz 96 8 ml ml NN cord-002490-kw8psrmz 96 9 Slide slide NN cord-002490-kw8psrmz 96 10 - - HYPH cord-002490-kw8psrmz 96 11 A A NNP cord-002490-kw8psrmz 96 12 - - HYPH cord-002490-kw8psrmz 96 13 Lyzer Lyzer NNP cord-002490-kw8psrmz 96 14 G2 G2 NNP cord-002490-kw8psrmz 96 15 cassette cassette NN cord-002490-kw8psrmz 96 16 ( ( -LRB- cord-002490-kw8psrmz 96 17 10,000 10,000 CD cord-002490-kw8psrmz 96 18 MWCO MWCO NNPS cord-002490-kw8psrmz 96 19 : : : cord-002490-kw8psrmz 97 1 Thermo Thermo NNP cord-002490-kw8psrmz 97 2 Scientific Scientific NNP cord-002490-kw8psrmz 97 3 , , , cord-002490-kw8psrmz 97 4 USA USA NNP cord-002490-kw8psrmz 97 5 ) ) -RRB- cord-002490-kw8psrmz 97 6 . . . cord-002490-kw8psrmz 98 1 All all DT cord-002490-kw8psrmz 98 2 virus virus NN cord-002490-kw8psrmz 98 3 culture culture NN cord-002490-kw8psrmz 98 4 and and CC cord-002490-kw8psrmz 98 5 purification purification NN cord-002490-kw8psrmz 98 6 , , , cord-002490-kw8psrmz 98 7 and and CC cord-002490-kw8psrmz 98 8 handling handling NN cord-002490-kw8psrmz 98 9 of of IN cord-002490-kw8psrmz 98 10 infectious infectious JJ cord-002490-kw8psrmz 98 11 materials material NNS cord-002490-kw8psrmz 98 12 was be VBD cord-002490-kw8psrmz 98 13 carried carry VBN cord-002490-kw8psrmz 98 14 out out RP cord-002490-kw8psrmz 98 15 at at IN cord-002490-kw8psrmz 98 16 the the DT cord-002490-kw8psrmz 98 17 National National NNP cord-002490-kw8psrmz 98 18 Microbiology Microbiology NNP cord-002490-kw8psrmz 98 19 Laboratory Laboratory NNP cord-002490-kw8psrmz 98 20 within within IN cord-002490-kw8psrmz 98 21 the the DT cord-002490-kw8psrmz 98 22 biosafety biosafety NN cord-002490-kw8psrmz 98 23 level level NN cord-002490-kw8psrmz 98 24 4 4 CD cord-002490-kw8psrmz 98 25 laboratories laboratory NNS cord-002490-kw8psrmz 98 26 in in IN cord-002490-kw8psrmz 98 27 Winnipeg Winnipeg NNP cord-002490-kw8psrmz 98 28 , , , cord-002490-kw8psrmz 98 29 Canada Canada NNP cord-002490-kw8psrmz 98 30 . . . cord-002490-kw8psrmz 99 1 Virus virus NN cord-002490-kw8psrmz 99 2 specimens specimen NNS cord-002490-kw8psrmz 99 3 ( ( -LRB- cord-002490-kw8psrmz 99 4 4 4 CD cord-002490-kw8psrmz 99 5 ul ul NN cord-002490-kw8psrmz 99 6 ) ) -RRB- cord-002490-kw8psrmz 99 7 were be VBD cord-002490-kw8psrmz 99 8 plunge plunge NN cord-002490-kw8psrmz 99 9 - - HYPH cord-002490-kw8psrmz 99 10 frozen freeze VBN cord-002490-kw8psrmz 99 11 on on IN cord-002490-kw8psrmz 99 12 glow glow NN cord-002490-kw8psrmz 99 13 - - HYPH cord-002490-kw8psrmz 99 14 discharged discharge VBN cord-002490-kw8psrmz 99 15 Quantifoil Quantifoil NNP cord-002490-kw8psrmz 99 16 grids grid NNS cord-002490-kw8psrmz 99 17 ( ( -LRB- cord-002490-kw8psrmz 99 18 2 2 CD cord-002490-kw8psrmz 99 19 um um UH cord-002490-kw8psrmz 99 20 holes hole NNS cord-002490-kw8psrmz 99 21 , , , cord-002490-kw8psrmz 99 22 at at IN cord-002490-kw8psrmz 99 23 1um 1um JJ cord-002490-kw8psrmz 99 24 intervals interval NNS cord-002490-kw8psrmz 99 25 : : : cord-002490-kw8psrmz 100 1 Quantifoil Quantifoil NNP cord-002490-kw8psrmz 100 2 , , , cord-002490-kw8psrmz 100 3 Germany Germany NNP cord-002490-kw8psrmz 100 4 ) ) -RRB- cord-002490-kw8psrmz 100 5 . . . cord-002490-kw8psrmz 101 1 As as IN cord-002490-kw8psrmz 101 2 a a DT cord-002490-kw8psrmz 101 3 focussing focusse VBG cord-002490-kw8psrmz 101 4 aid aid NN cord-002490-kw8psrmz 101 5 , , , cord-002490-kw8psrmz 101 6 a a DT cord-002490-kw8psrmz 101 7 BSA BSA NNP cord-002490-kw8psrmz 101 8 - - HYPH cord-002490-kw8psrmz 101 9 colloidal colloidal NN cord-002490-kw8psrmz 101 10 gold gold NN cord-002490-kw8psrmz 101 11 suspension suspension NN cord-002490-kw8psrmz 101 12 ( ( -LRB- cord-002490-kw8psrmz 101 13 10 10 CD cord-002490-kw8psrmz 101 14 nm nm NN cord-002490-kw8psrmz 101 15 particles particle NNS cord-002490-kw8psrmz 101 16 : : : cord-002490-kw8psrmz 102 1 Aurion Aurion NNP cord-002490-kw8psrmz 102 2 , , , cord-002490-kw8psrmz 102 3 The the DT cord-002490-kw8psrmz 102 4 Netherlands Netherlands NNP cord-002490-kw8psrmz 102 5 ) ) -RRB- cord-002490-kw8psrmz 102 6 was be VBD cord-002490-kw8psrmz 102 7 added add VBN cord-002490-kw8psrmz 102 8 to to IN cord-002490-kw8psrmz 102 9 virus virus NN cord-002490-kw8psrmz 102 10 preparations preparation NNS cord-002490-kw8psrmz 102 11 at at IN cord-002490-kw8psrmz 102 12 a a DT cord-002490-kw8psrmz 102 13 rate rate NN cord-002490-kw8psrmz 102 14 of of IN cord-002490-kw8psrmz 102 15 10 10 CD cord-002490-kw8psrmz 102 16 per per NN cord-002490-kw8psrmz 102 17 cent cent NN cord-002490-kw8psrmz 102 18 by by IN cord-002490-kw8psrmz 102 19 volume volume NN cord-002490-kw8psrmz 102 20 . . . cord-002490-kw8psrmz 103 1 Freezing freeze VBG cord-002490-kw8psrmz 103 2 was be VBD cord-002490-kw8psrmz 103 3 carried carry VBN cord-002490-kw8psrmz 103 4 out out RP cord-002490-kw8psrmz 103 5 using use VBG cord-002490-kw8psrmz 103 6 liquid liquid JJ cord-002490-kw8psrmz 103 7 ethane ethane NN cord-002490-kw8psrmz 103 8 as as IN cord-002490-kw8psrmz 103 9 a a DT cord-002490-kw8psrmz 103 10 cryogen cryogen NN cord-002490-kw8psrmz 103 11 with with IN cord-002490-kw8psrmz 103 12 a a DT cord-002490-kw8psrmz 103 13 Vitrobot Vitrobot NNP cord-002490-kw8psrmz 103 14 ( ( -LRB- cord-002490-kw8psrmz 103 15 Mark Mark NNP cord-002490-kw8psrmz 103 16 IV IV NNP cord-002490-kw8psrmz 103 17 : : : cord-002490-kw8psrmz 103 18 FEI FEI NNP cord-002490-kw8psrmz 103 19 Company Company NNP cord-002490-kw8psrmz 103 20 , , , cord-002490-kw8psrmz 103 21 USA USA NNP cord-002490-kw8psrmz 103 22 ) ) -RRB- cord-002490-kw8psrmz 103 23 . . . cord-002490-kw8psrmz 104 1 Images image NNS cord-002490-kw8psrmz 104 2 were be VBD cord-002490-kw8psrmz 104 3 taken take VBN cord-002490-kw8psrmz 104 4 at at IN cord-002490-kw8psrmz 104 5 200 200 CD cord-002490-kw8psrmz 104 6 kV kV NNP cord-002490-kw8psrmz 104 7 with with IN cord-002490-kw8psrmz 104 8 a a DT cord-002490-kw8psrmz 104 9 Tecnai Tecnai NNP cord-002490-kw8psrmz 104 10 20 20 CD cord-002490-kw8psrmz 104 11 G2 G2 NNP cord-002490-kw8psrmz 104 12 electron electron NN cord-002490-kw8psrmz 104 13 microscope microscope NN cord-002490-kw8psrmz 104 14 ( ( -LRB- cord-002490-kw8psrmz 104 15 FEI FEI NNP cord-002490-kw8psrmz 104 16 ) ) -RRB- cord-002490-kw8psrmz 104 17 using use VBG cord-002490-kw8psrmz 104 18 a a DT cord-002490-kw8psrmz 104 19 Gatan Gatan NNP cord-002490-kw8psrmz 104 20 CT3500TR CT3500TR NNP cord-002490-kw8psrmz 104 21 single single JJ cord-002490-kw8psrmz 104 22 tilt tilt NN cord-002490-kw8psrmz 104 23 rotation rotation NN cord-002490-kw8psrmz 104 24 specimen specimen NN cord-002490-kw8psrmz 104 25 holder holder NN cord-002490-kw8psrmz 104 26 at at IN cord-002490-kw8psrmz 104 27 − − NNP cord-002490-kw8psrmz 104 28 185 185 CD cord-002490-kw8psrmz 104 29 ° ° NN cord-002490-kw8psrmz 104 30 C c NN cord-002490-kw8psrmz 104 31 . . . cord-002490-kw8psrmz 105 1 Data datum NNS cord-002490-kw8psrmz 105 2 was be VBD cord-002490-kw8psrmz 105 3 recorded record VBN cord-002490-kw8psrmz 105 4 with with IN cord-002490-kw8psrmz 105 5 an an DT cord-002490-kw8psrmz 105 6 Eagle Eagle NNP cord-002490-kw8psrmz 105 7 4 4 CD cord-002490-kw8psrmz 105 8 K K NNP cord-002490-kw8psrmz 105 9 CCD ccd NN cord-002490-kw8psrmz 105 10 camera camera NN cord-002490-kw8psrmz 105 11 ( ( -LRB- cord-002490-kw8psrmz 105 12 FEI FEI NNP cord-002490-kw8psrmz 105 13 Company Company NNP cord-002490-kw8psrmz 105 14 , , , cord-002490-kw8psrmz 105 15 USA USA NNP cord-002490-kw8psrmz 105 16 ) ) -RRB- cord-002490-kw8psrmz 105 17 at at IN cord-002490-kw8psrmz 105 18 50,000X 50,000x CD cord-002490-kw8psrmz 105 19 magnification magnification NN cord-002490-kw8psrmz 105 20 at at IN cord-002490-kw8psrmz 105 21 2 2 CD cord-002490-kw8psrmz 105 22 - - SYM cord-002490-kw8psrmz 105 23 4 4 CD cord-002490-kw8psrmz 105 24 um um UH cord-002490-kw8psrmz 105 25 defocus defocus NN cord-002490-kw8psrmz 105 26 , , , cord-002490-kw8psrmz 105 27 with with IN cord-002490-kw8psrmz 105 28 a a DT cord-002490-kw8psrmz 105 29 dose dose NN cord-002490-kw8psrmz 105 30 of of IN cord-002490-kw8psrmz 105 31 10 10 CD cord-002490-kw8psrmz 105 32 electrons electron NNS cord-002490-kw8psrmz 105 33 / / SYM cord-002490-kw8psrmz 105 34 Å å NN cord-002490-kw8psrmz 105 35 2 2 CD cord-002490-kw8psrmz 105 36 . . . cord-002490-kw8psrmz 106 1 This this DT cord-002490-kw8psrmz 106 2 gave give VBD cord-002490-kw8psrmz 106 3 a a DT cord-002490-kw8psrmz 106 4 pixel pixel NN cord-002490-kw8psrmz 106 5 size size NN cord-002490-kw8psrmz 106 6 of of IN cord-002490-kw8psrmz 106 7 2.15 2.15 CD cord-002490-kw8psrmz 106 8 Å å NN cord-002490-kw8psrmz 106 9 at at IN cord-002490-kw8psrmz 106 10 the the DT cord-002490-kw8psrmz 106 11 CCD ccd NN cord-002490-kw8psrmz 106 12 chip chip NN cord-002490-kw8psrmz 106 13 . . . cord-002490-kw8psrmz 107 1 Image image NN cord-002490-kw8psrmz 107 2 recording recording NN cord-002490-kw8psrmz 107 3 used use VBD cord-002490-kw8psrmz 107 4 the the DT cord-002490-kw8psrmz 107 5 automated automate VBN cord-002490-kw8psrmz 107 6 low low JJ cord-002490-kw8psrmz 107 7 - - HYPH cord-002490-kw8psrmz 107 8 dose dose NN cord-002490-kw8psrmz 107 9 TIA TIA NNP cord-002490-kw8psrmz 107 10 software software NN cord-002490-kw8psrmz 107 11 ( ( -LRB- cord-002490-kw8psrmz 107 12 FEI FEI NNP cord-002490-kw8psrmz 107 13 Company Company NNP cord-002490-kw8psrmz 107 14 , , , cord-002490-kw8psrmz 107 15 USA USA NNP cord-002490-kw8psrmz 107 16 ) ) -RRB- cord-002490-kw8psrmz 107 17 . . . cord-002490-kw8psrmz 108 1 Xplore3D Xplore3D NNP cord-002490-kw8psrmz 108 2 data data NNP cord-002490-kw8psrmz 108 3 acquisition acquisition NN cord-002490-kw8psrmz 108 4 software software NN cord-002490-kw8psrmz 108 5 ( ( -LRB- cord-002490-kw8psrmz 108 6 FEI FEI NNP cord-002490-kw8psrmz 108 7 Company Company NNP cord-002490-kw8psrmz 108 8 , , , cord-002490-kw8psrmz 108 9 USA USA NNP cord-002490-kw8psrmz 108 10 ) ) -RRB- cord-002490-kw8psrmz 108 11 was be VBD cord-002490-kw8psrmz 108 12 used use VBN cord-002490-kw8psrmz 108 13 to to TO cord-002490-kw8psrmz 108 14 automate automate VB cord-002490-kw8psrmz 108 15 eucentric eucentric JJ cord-002490-kw8psrmz 108 16 height height NN cord-002490-kw8psrmz 108 17 and and CC cord-002490-kw8psrmz 108 18 focus focus NN cord-002490-kw8psrmz 108 19 . . . cord-002490-kw8psrmz 109 1 Image image NN cord-002490-kw8psrmz 109 2 processing processing NN cord-002490-kw8psrmz 109 3 . . . cord-002490-kw8psrmz 110 1 Particle particle NN cord-002490-kw8psrmz 110 2 selection selection NN cord-002490-kw8psrmz 110 3 was be VBD cord-002490-kw8psrmz 110 4 carried carry VBN cord-002490-kw8psrmz 110 5 out out RP cord-002490-kw8psrmz 110 6 using use VBG cord-002490-kw8psrmz 110 7 EMAN EMAN NNP cord-002490-kw8psrmz 110 8 , , , cord-002490-kw8psrmz 110 9 and and CC cord-002490-kw8psrmz 110 10 correction correction NN cord-002490-kw8psrmz 110 11 for for IN cord-002490-kw8psrmz 110 12 contrast contrast NN cord-002490-kw8psrmz 110 13 transfer transfer NN cord-002490-kw8psrmz 110 14 function function NN cord-002490-kw8psrmz 110 15 ( ( -LRB- cord-002490-kw8psrmz 110 16 CTF CTF NNP cord-002490-kw8psrmz 110 17 ) ) -RRB- cord-002490-kw8psrmz 110 18 was be VBD cord-002490-kw8psrmz 110 19 made make VBN cord-002490-kw8psrmz 110 20 using use VBG cord-002490-kw8psrmz 110 21 EMAN2 eman2 PRP cord-002490-kw8psrmz 110 22 38 38 CD cord-002490-kw8psrmz 110 23 . . . cord-002490-kw8psrmz 111 1 Image image NN cord-002490-kw8psrmz 111 2 processing processing NN cord-002490-kw8psrmz 111 3 and and CC cord-002490-kw8psrmz 111 4 3-D 3-d JJ cord-002490-kw8psrmz 111 5 structures structure NNS cord-002490-kw8psrmz 111 6 used use VBD cord-002490-kw8psrmz 111 7 the the DT cord-002490-kw8psrmz 111 8 SPIDER spider NN cord-002490-kw8psrmz 111 9 and and CC cord-002490-kw8psrmz 111 10 WEB web NN cord-002490-kw8psrmz 111 11 programs program NNS cord-002490-kw8psrmz 111 12 39 39 CD cord-002490-kw8psrmz 111 13 . . . cord-002490-kw8psrmz 112 1 Analyses analysis NNS cord-002490-kw8psrmz 112 2 were be VBD cord-002490-kw8psrmz 112 3 carried carry VBN cord-002490-kw8psrmz 112 4 out out RP cord-002490-kw8psrmz 112 5 on on IN cord-002490-kw8psrmz 112 6 a a DT cord-002490-kw8psrmz 112 7 Mac Mac NNP cord-002490-kw8psrmz 112 8 Pro Pro NNP cord-002490-kw8psrmz 112 9 12-core 12-core CD cord-002490-kw8psrmz 112 10 computer computer NN cord-002490-kw8psrmz 112 11 ( ( -LRB- cord-002490-kw8psrmz 112 12 Apple Apple NNP cord-002490-kw8psrmz 112 13 Inc Inc NNP cord-002490-kw8psrmz 112 14 , , , cord-002490-kw8psrmz 112 15 with with IN cord-002490-kw8psrmz 112 16 2.93 2.93 CD cord-002490-kw8psrmz 112 17 GHzIntel GHzIntel NNS cord-002490-kw8psrmz 112 18 Xeon Xeon NNP cord-002490-kw8psrmz 112 19 Nehalem Nehalem NNP cord-002490-kw8psrmz 112 20 processors processor NNS cord-002490-kw8psrmz 112 21 , , , cord-002490-kw8psrmz 112 22 32 32 CD cord-002490-kw8psrmz 112 23 GB GB NNP cord-002490-kw8psrmz 112 24 RAM RAM NNP cord-002490-kw8psrmz 112 25 , , , cord-002490-kw8psrmz 112 26 running run VBG cord-002490-kw8psrmz 112 27 OS OS NNP cord-002490-kw8psrmz 112 28 X X NNP cord-002490-kw8psrmz 112 29 10.6.7 10.6.7 NNP cord-002490-kw8psrmz 112 30 ) ) -RRB- cord-002490-kw8psrmz 112 31 and and CC cord-002490-kw8psrmz 112 32 on on IN cord-002490-kw8psrmz 112 33 a a DT cord-002490-kw8psrmz 112 34 Dell Dell NNP cord-002490-kw8psrmz 112 35 6-Core 6-core CD cord-002490-kw8psrmz 112 36 Power Power NNP cord-002490-kw8psrmz 112 37 Edge Edge NNP cord-002490-kw8psrmz 112 38 ( ( -LRB- cord-002490-kw8psrmz 112 39 R900 r900 NN cord-002490-kw8psrmz 112 40 , , , cord-002490-kw8psrmz 112 41 64-bit 64-bit CD cord-002490-kw8psrmz 112 42 Xeon Xeon NNP cord-002490-kw8psrmz 112 43 X7460 X7460 NNP cord-002490-kw8psrmz 112 44 2.67 2.67 CD cord-002490-kw8psrmz 112 45 GHz GHz NNPS cord-002490-kw8psrmz 112 46 CPUs cpu NNS cord-002490-kw8psrmz 112 47 , , , cord-002490-kw8psrmz 112 48 256 256 CD cord-002490-kw8psrmz 112 49 GB GB NNP cord-002490-kw8psrmz 112 50 RAM RAM NNP cord-002490-kw8psrmz 112 51 , , , cord-002490-kw8psrmz 112 52 running run VBG cord-002490-kw8psrmz 112 53 on on IN cord-002490-kw8psrmz 112 54 Linux Linux NNP cord-002490-kw8psrmz 112 55 OS5.2 os5.2 NN cord-002490-kw8psrmz 112 56 ) ) -RRB- cord-002490-kw8psrmz 112 57 . . . cord-002490-kw8psrmz 113 1 Correction correction NN cord-002490-kw8psrmz 113 2 of of IN cord-002490-kw8psrmz 113 3 images image NNS cord-002490-kw8psrmz 113 4 for for IN cord-002490-kw8psrmz 113 5 the the DT cord-002490-kw8psrmz 113 6 CTF ctf NN cord-002490-kw8psrmz 113 7 was be VBD cord-002490-kw8psrmz 113 8 carried carry VBN cord-002490-kw8psrmz 113 9 out out RP cord-002490-kw8psrmz 113 10 with with IN cord-002490-kw8psrmz 113 11 the the DT cord-002490-kw8psrmz 113 12 " " `` cord-002490-kw8psrmz 113 13 e2ctf.py e2ctf.py NNP cord-002490-kw8psrmz 113 14 " " '' cord-002490-kw8psrmz 113 15 module module NN cord-002490-kw8psrmz 113 16 in in IN cord-002490-kw8psrmz 113 17 EMAN2 EMAN2 NNP cord-002490-kw8psrmz 114 1 This this DT cord-002490-kw8psrmz 114 2 estimated estimate VBN cord-002490-kw8psrmz 114 3 defocus defocus NN cord-002490-kw8psrmz 114 4 , , , cord-002490-kw8psrmz 114 5 and and CC cord-002490-kw8psrmz 114 6 used use VBD cord-002490-kw8psrmz 114 7 phase phase NN cord-002490-kw8psrmz 114 8 - - HYPH cord-002490-kw8psrmz 114 9 flipping flip VBG cord-002490-kw8psrmz 114 10 to to TO cord-002490-kw8psrmz 114 11 correct correct VB cord-002490-kw8psrmz 114 12 for for IN cord-002490-kw8psrmz 114 13 the the DT cord-002490-kw8psrmz 114 14 CTF ctf NN cord-002490-kw8psrmz 114 15 . . . cord-002490-kw8psrmz 115 1 Spike spike NN cord-002490-kw8psrmz 115 2 images image NNS cord-002490-kw8psrmz 115 3 ( ( -LRB- cord-002490-kw8psrmz 115 4 n n NN cord-002490-kw8psrmz 115 5 = = SYM cord-002490-kw8psrmz 115 6 32,960 32,960 CD cord-002490-kw8psrmz 115 7 ) ) -RRB- cord-002490-kw8psrmz 115 8 , , , cord-002490-kw8psrmz 115 9 and and CC cord-002490-kw8psrmz 115 10 half half JJ cord-002490-kw8psrmz 115 11 - - HYPH cord-002490-kw8psrmz 115 12 width width NN cord-002490-kw8psrmz 115 13 images image NNS cord-002490-kw8psrmz 115 14 of of IN cord-002490-kw8psrmz 115 15 the the DT cord-002490-kw8psrmz 115 16 virus virus NN cord-002490-kw8psrmz 115 17 ( ( -LRB- cord-002490-kw8psrmz 115 18 n n NN cord-002490-kw8psrmz 115 19 = = SYM cord-002490-kw8psrmz 115 20 28,976 28,976 CD cord-002490-kw8psrmz 115 21 ) ) -RRB- cord-002490-kw8psrmz 115 22 were be VBD cord-002490-kw8psrmz 115 23 selected select VBN cord-002490-kw8psrmz 115 24 for for IN cord-002490-kw8psrmz 115 25 image image NN cord-002490-kw8psrmz 115 26 analysis analysis NN cord-002490-kw8psrmz 115 27 . . . cord-002490-kw8psrmz 116 1 In in IN cord-002490-kw8psrmz 116 2 all all DT cord-002490-kw8psrmz 116 3 subsequent subsequent JJ cord-002490-kw8psrmz 116 4 sections section NNS cord-002490-kw8psrmz 116 5 , , , cord-002490-kw8psrmz 116 6 SPIDER spider NN cord-002490-kw8psrmz 116 7 software software NN cord-002490-kw8psrmz 116 8 was be VBD cord-002490-kw8psrmz 116 9 used use VBN cord-002490-kw8psrmz 116 10 for for IN cord-002490-kw8psrmz 116 11 image image NN cord-002490-kw8psrmz 116 12 processing processing NN cord-002490-kw8psrmz 116 13 except except IN cord-002490-kw8psrmz 116 14 where where WRB cord-002490-kw8psrmz 116 15 stated state VBN cord-002490-kw8psrmz 116 16 otherwise otherwise RB cord-002490-kw8psrmz 116 17 . . . cord-002490-kw8psrmz 117 1 Methods method NNS cord-002490-kw8psrmz 117 2 are be VBP cord-002490-kw8psrmz 117 3 described describe VBN cord-002490-kw8psrmz 117 4 and and CC cord-002490-kw8psrmz 117 5 illustrated illustrate VBN cord-002490-kw8psrmz 117 6 in in IN cord-002490-kw8psrmz 117 7 Supplementary Supplementary NNP cord-002490-kw8psrmz 117 8 Figs Figs NNP cord-002490-kw8psrmz 117 9 S1-S3 S1-S3 NNP cord-002490-kw8psrmz 117 10 . . . cord-002490-kw8psrmz 118 1 Resolution resolution NN cord-002490-kw8psrmz 118 2 of of IN cord-002490-kw8psrmz 118 3 the the DT cord-002490-kw8psrmz 118 4 final final JJ cord-002490-kw8psrmz 118 5 cryo cryo NN cord-002490-kw8psrmz 118 6 - - HYPH cord-002490-kw8psrmz 118 7 EM EM NNP cord-002490-kw8psrmz 118 8 structure structure NN cord-002490-kw8psrmz 118 9 was be VBD cord-002490-kw8psrmz 118 10 estimated estimate VBN cord-002490-kw8psrmz 118 11 using use VBG cord-002490-kw8psrmz 118 12 the the DT cord-002490-kw8psrmz 118 13 Fourier Fourier NNP cord-002490-kw8psrmz 118 14 shell shell NN cord-002490-kw8psrmz 118 15 correlation correlation NN cord-002490-kw8psrmz 118 16 0.143 0.143 CD cord-002490-kw8psrmz 118 17 criterion criterion NN cord-002490-kw8psrmz 118 18 32 32 CD cord-002490-kw8psrmz 118 19 ( ( -LRB- cord-002490-kw8psrmz 118 20 Supplementary Supplementary NNP cord-002490-kw8psrmz 118 21 Fig Fig NNP cord-002490-kw8psrmz 118 22 . . . cord-002490-kw8psrmz 118 23 S4 S4 NNP cord-002490-kw8psrmz 118 24 ) ) -RRB- cord-002490-kw8psrmz 118 25 . . . cord-002490-kw8psrmz 119 1 Single single JJ cord-002490-kw8psrmz 119 2 particle particle NN cord-002490-kw8psrmz 119 3 image image NN cord-002490-kw8psrmz 119 4 analysis analysis NN cord-002490-kw8psrmz 119 5 : : : cord-002490-kw8psrmz 119 6 half half NN cord-002490-kw8psrmz 119 7 width width NN cord-002490-kw8psrmz 119 8 of of IN cord-002490-kw8psrmz 119 9 virus virus NN cord-002490-kw8psrmz 119 10 images image NNS cord-002490-kw8psrmz 119 11 . . . cord-002490-kw8psrmz 120 1 Specific specific JJ cord-002490-kw8psrmz 120 2 image image NN cord-002490-kw8psrmz 120 3 regions region NNS cord-002490-kw8psrmz 120 4 were be VBD cord-002490-kw8psrmz 120 5 analysed analyse VBN cord-002490-kw8psrmz 120 6 for for IN cord-002490-kw8psrmz 120 7 single single JJ cord-002490-kw8psrmz 120 8 particle particle NN cord-002490-kw8psrmz 120 9 image image NN cord-002490-kw8psrmz 120 10 processing processing NN cord-002490-kw8psrmz 120 11 . . . cord-002490-kw8psrmz 121 1 Two two CD cord-002490-kw8psrmz 121 2 - - HYPH cord-002490-kw8psrmz 121 3 dimensional dimensional JJ cord-002490-kw8psrmz 121 4 masks mask NNS cord-002490-kw8psrmz 121 5 were be VBD cord-002490-kw8psrmz 121 6 generated generate VBN cord-002490-kw8psrmz 121 7 in in IN cord-002490-kw8psrmz 121 8 the the DT cord-002490-kw8psrmz 121 9 Canvas Canvas NNP cord-002490-kw8psrmz 121 10 X x NN cord-002490-kw8psrmz 121 11 software software NN cord-002490-kw8psrmz 121 12 package package NN cord-002490-kw8psrmz 121 13 ( ( -LRB- cord-002490-kw8psrmz 121 14 ACD ACD NNP cord-002490-kw8psrmz 121 15 Systems Systems NNPS cord-002490-kw8psrmz 121 16 , , , cord-002490-kw8psrmz 121 17 Seattle Seattle NNP cord-002490-kw8psrmz 121 18 , , , cord-002490-kw8psrmz 121 19 Washington Washington NNP cord-002490-kw8psrmz 121 20 , , , cord-002490-kw8psrmz 121 21 USA USA NNP cord-002490-kw8psrmz 121 22 ) ) -RRB- cord-002490-kw8psrmz 121 23 . . . cord-002490-kw8psrmz 122 1 Masks mask NNS cord-002490-kw8psrmz 122 2 were be VBD cord-002490-kw8psrmz 122 3 imported import VBN cord-002490-kw8psrmz 122 4 as as IN cord-002490-kw8psrmz 122 5 tiff tiff NN cord-002490-kw8psrmz 122 6 files file NNS cord-002490-kw8psrmz 122 7 for for IN cord-002490-kw8psrmz 122 8 image image NN cord-002490-kw8psrmz 122 9 processing processing NN cord-002490-kw8psrmz 122 10 in in IN cord-002490-kw8psrmz 122 11 SPIDER SPIDER NNP cord-002490-kw8psrmz 122 12 . . . cord-002490-kw8psrmz 123 1 Reference reference NN cord-002490-kw8psrmz 123 2 - - HYPH cord-002490-kw8psrmz 123 3 free free JJ cord-002490-kw8psrmz 123 4 classification classification NN cord-002490-kw8psrmz 123 5 , , , cord-002490-kw8psrmz 123 6 to to TO cord-002490-kw8psrmz 123 7 bring bring VB cord-002490-kw8psrmz 123 8 all all DT cord-002490-kw8psrmz 123 9 images image NNS cord-002490-kw8psrmz 123 10 into into IN cord-002490-kw8psrmz 123 11 register register NN cord-002490-kw8psrmz 123 12 , , , cord-002490-kw8psrmz 123 13 was be VBD cord-002490-kw8psrmz 123 14 carried carry VBN cord-002490-kw8psrmz 123 15 out out RP cord-002490-kw8psrmz 123 16 with with IN cord-002490-kw8psrmz 123 17 the the DT cord-002490-kw8psrmz 123 18 EMAN EMAN NNP cord-002490-kw8psrmz 123 19 software software NN cord-002490-kw8psrmz 123 20 package package NN cord-002490-kw8psrmz 123 21 . . . cord-002490-kw8psrmz 124 1 The the DT cord-002490-kw8psrmz 124 2 class class NN cord-002490-kw8psrmz 124 3 average average NN cord-002490-kw8psrmz 124 4 was be VBD cord-002490-kw8psrmz 124 5 then then RB cord-002490-kw8psrmz 124 6 used use VBN cord-002490-kw8psrmz 124 7 as as IN cord-002490-kw8psrmz 124 8 reference reference NN cord-002490-kw8psrmz 124 9 to to TO cord-002490-kw8psrmz 124 10 bring bring VB cord-002490-kw8psrmz 124 11 all all PDT cord-002490-kw8psrmz 124 12 the the DT cord-002490-kw8psrmz 124 13 images image NNS cord-002490-kw8psrmz 124 14 into into IN cord-002490-kw8psrmz 124 15 rotational rotational JJ cord-002490-kw8psrmz 124 16 and and CC cord-002490-kw8psrmz 124 17 translational translational JJ cord-002490-kw8psrmz 124 18 register register NN cord-002490-kw8psrmz 124 19 . . . cord-002490-kw8psrmz 125 1 These these DT cord-002490-kw8psrmz 125 2 pre pre VBP cord-002490-kw8psrmz 125 3 - - JJ cord-002490-kw8psrmz 125 4 aligned align VBN cord-002490-kw8psrmz 125 5 images image NNS cord-002490-kw8psrmz 125 6 were be VBD cord-002490-kw8psrmz 125 7 then then RB cord-002490-kw8psrmz 125 8 used use VBN cord-002490-kw8psrmz 125 9 with with IN cord-002490-kw8psrmz 125 10 a a DT cord-002490-kw8psrmz 125 11 series series NN cord-002490-kw8psrmz 125 12 of of IN cord-002490-kw8psrmz 125 13 masks mask NNS cord-002490-kw8psrmz 125 14 for for IN cord-002490-kw8psrmz 125 15 various various JJ cord-002490-kw8psrmz 125 16 regions region NNS cord-002490-kw8psrmz 125 17 of of IN cord-002490-kw8psrmz 125 18 interest interest NN cord-002490-kw8psrmz 125 19 , , , cord-002490-kw8psrmz 125 20 both both DT cord-002490-kw8psrmz 125 21 including include VBG cord-002490-kw8psrmz 125 22 the the DT cord-002490-kw8psrmz 125 23 lipid lipid NN cord-002490-kw8psrmz 125 24 bilayer bilayer NN cord-002490-kw8psrmz 125 25 , , , cord-002490-kw8psrmz 125 26 and and CC cord-002490-kw8psrmz 125 27 with with IN cord-002490-kw8psrmz 125 28 this this DT cord-002490-kw8psrmz 125 29 region region NN cord-002490-kw8psrmz 125 30 masked mask VBN cord-002490-kw8psrmz 125 31 . . . cord-002490-kw8psrmz 126 1 EMAN EMAN NNP cord-002490-kw8psrmz 126 2 was be VBD cord-002490-kw8psrmz 126 3 again again RB cord-002490-kw8psrmz 126 4 used use VBN cord-002490-kw8psrmz 126 5 to to TO cord-002490-kw8psrmz 126 6 perform perform VB cord-002490-kw8psrmz 126 7 a a DT cord-002490-kw8psrmz 126 8 reference reference NN cord-002490-kw8psrmz 126 9 free free JJ cord-002490-kw8psrmz 126 10 classification classification NN cord-002490-kw8psrmz 126 11 , , , cord-002490-kw8psrmz 126 12 and and CC cord-002490-kw8psrmz 126 13 the the DT cord-002490-kw8psrmz 126 14 averages average NNS cord-002490-kw8psrmz 126 15 generated generate VBN cord-002490-kw8psrmz 126 16 were be VBD cord-002490-kw8psrmz 126 17 processed process VBN cord-002490-kw8psrmz 126 18 in in IN cord-002490-kw8psrmz 126 19 SPIDER SPIDER NNP cord-002490-kw8psrmz 126 20 to to TO cord-002490-kw8psrmz 126 21 perform perform VB cord-002490-kw8psrmz 126 22 a a DT cord-002490-kw8psrmz 126 23 multi multi JJ cord-002490-kw8psrmz 126 24 - - JJ cord-002490-kw8psrmz 126 25 reference reference NN cord-002490-kw8psrmz 126 26 alignment alignment NN cord-002490-kw8psrmz 126 27 . . . cord-002490-kw8psrmz 127 1 The the DT cord-002490-kw8psrmz 127 2 results result NNS cord-002490-kw8psrmz 127 3 of of IN cord-002490-kw8psrmz 127 4 these these DT cord-002490-kw8psrmz 127 5 analyses analysis NNS cord-002490-kw8psrmz 127 6 were be VBD cord-002490-kw8psrmz 127 7 then then RB cord-002490-kw8psrmz 127 8 applied apply VBN cord-002490-kw8psrmz 127 9 to to IN cord-002490-kw8psrmz 127 10 both both CC cord-002490-kw8psrmz 127 11 masked mask VBN cord-002490-kw8psrmz 127 12 and and CC cord-002490-kw8psrmz 127 13 unmasked unmask VBN cord-002490-kw8psrmz 127 14 images image NNS cord-002490-kw8psrmz 127 15 to to TO cord-002490-kw8psrmz 127 16 investigate investigate VB cord-002490-kw8psrmz 127 17 effect effect NN cord-002490-kw8psrmz 127 18 of of IN cord-002490-kw8psrmz 127 19 the the DT cord-002490-kw8psrmz 127 20 masking masking NN cord-002490-kw8psrmz 127 21 procedure procedure NN cord-002490-kw8psrmz 127 22 and and CC cord-002490-kw8psrmz 127 23 periodicity periodicity NN cord-002490-kw8psrmz 127 24 of of IN cord-002490-kw8psrmz 127 25 the the DT cord-002490-kw8psrmz 127 26 different different JJ cord-002490-kw8psrmz 127 27 layers layer NNS cord-002490-kw8psrmz 127 28 including include VBG cord-002490-kw8psrmz 127 29 the the DT cord-002490-kw8psrmz 127 30 spikes spike NNS cord-002490-kw8psrmz 127 31 , , , cord-002490-kw8psrmz 127 32 viral viral JJ cord-002490-kw8psrmz 127 33 envelope envelope NN cord-002490-kw8psrmz 127 34 and and CC cord-002490-kw8psrmz 127 35 nucleocapsid nucleocapsid NN cord-002490-kw8psrmz 127 36 . . . cord-002490-kw8psrmz 128 1 Single single JJ cord-002490-kw8psrmz 128 2 particle particle NN cord-002490-kw8psrmz 128 3 image image NN cord-002490-kw8psrmz 128 4 analysis analysis NN cord-002490-kw8psrmz 128 5 : : : cord-002490-kw8psrmz 128 6 GP GP NNP cord-002490-kw8psrmz 128 7 Spike Spike NNP cord-002490-kw8psrmz 128 8 analysis analysis NN cord-002490-kw8psrmz 128 9 . . . cord-002490-kw8psrmz 129 1 The the DT cord-002490-kw8psrmz 129 2 masking masking NN cord-002490-kw8psrmz 129 3 described describe VBN cord-002490-kw8psrmz 129 4 for for IN cord-002490-kw8psrmz 129 5 2-D 2-d JJ cord-002490-kw8psrmz 129 6 image image NN cord-002490-kw8psrmz 129 7 analysis analysis NN cord-002490-kw8psrmz 129 8 was be VBD cord-002490-kw8psrmz 129 9 adapted adapt VBN cord-002490-kw8psrmz 129 10 to to IN cord-002490-kw8psrmz 129 11 3-D 3-d JJ cord-002490-kw8psrmz 129 12 projection projection NN cord-002490-kw8psrmz 129 13 matching matching NN cord-002490-kw8psrmz 129 14 of of IN cord-002490-kw8psrmz 129 15 EBOV EBOV NNP cord-002490-kw8psrmz 129 16 spike spike NN cord-002490-kw8psrmz 129 17 images image NNS cord-002490-kw8psrmz 129 18 ( ( -LRB- cord-002490-kw8psrmz 129 19 Supplementary Supplementary NNP cord-002490-kw8psrmz 129 20 Figs Figs NNP cord-002490-kw8psrmz 129 21 S1-S3 S1-S3 NNP cord-002490-kw8psrmz 129 22 ) ) -RRB- cord-002490-kw8psrmz 129 23 . . . cord-002490-kw8psrmz 130 1 For for IN cord-002490-kw8psrmz 130 2 3-D 3-d JJ cord-002490-kw8psrmz 130 3 processing processing NN cord-002490-kw8psrmz 130 4 , , , cord-002490-kw8psrmz 130 5 images image NNS cord-002490-kw8psrmz 130 6 were be VBD cord-002490-kw8psrmz 130 7 pre pre VBN cord-002490-kw8psrmz 130 8 - - VBN cord-002490-kw8psrmz 130 9 aligned align VBN cord-002490-kw8psrmz 130 10 to to IN cord-002490-kw8psrmz 130 11 a a DT cord-002490-kw8psrmz 130 12 global global JJ cord-002490-kw8psrmz 130 13 average average NN cord-002490-kw8psrmz 130 14 by by IN cord-002490-kw8psrmz 130 15 reference reference NN cord-002490-kw8psrmz 130 16 - - HYPH cord-002490-kw8psrmz 130 17 free free JJ cord-002490-kw8psrmz 130 18 classification classification NN cord-002490-kw8psrmz 130 19 in in IN cord-002490-kw8psrmz 130 20 EMAN EMAN NNP cord-002490-kw8psrmz 130 21 , , , cord-002490-kw8psrmz 130 22 followed follow VBN cord-002490-kw8psrmz 130 23 by by IN cord-002490-kw8psrmz 130 24 data data NN cord-002490-kw8psrmz 130 25 alignment alignment NN cord-002490-kw8psrmz 130 26 to to IN cord-002490-kw8psrmz 130 27 this this DT cord-002490-kw8psrmz 130 28 average average NN cord-002490-kw8psrmz 130 29 in in IN cord-002490-kw8psrmz 130 30 SPIDER SPIDER NNP cord-002490-kw8psrmz 130 31 . . . cord-002490-kw8psrmz 131 1 Pre pre VB cord-002490-kw8psrmz 131 2 - - JJ cord-002490-kw8psrmz 131 3 aligned align VBN cord-002490-kw8psrmz 131 4 images image NNS cord-002490-kw8psrmz 131 5 were be VBD cord-002490-kw8psrmz 131 6 then then RB cord-002490-kw8psrmz 131 7 masked mask VBN cord-002490-kw8psrmz 131 8 with with IN cord-002490-kw8psrmz 131 9 an an DT cord-002490-kw8psrmz 131 10 upside upside NN cord-002490-kw8psrmz 131 11 down down RB cord-002490-kw8psrmz 131 12 " " '' cord-002490-kw8psrmz 131 13 T"-shaped t"-shaped CD cord-002490-kw8psrmz 131 14 mask mask NN cord-002490-kw8psrmz 131 15 , , , cord-002490-kw8psrmz 131 16 thus thus RB cord-002490-kw8psrmz 131 17 selecting select VBG cord-002490-kw8psrmz 131 18 image image NN cord-002490-kw8psrmz 131 19 regions region NNS cord-002490-kw8psrmz 131 20 containing contain VBG cord-002490-kw8psrmz 131 21 both both CC cord-002490-kw8psrmz 131 22 the the DT cord-002490-kw8psrmz 131 23 lipid lipid NN cord-002490-kw8psrmz 131 24 bilayer bilayer NN cord-002490-kw8psrmz 131 25 and and CC cord-002490-kw8psrmz 131 26 a a DT cord-002490-kw8psrmz 131 27 single single JJ cord-002490-kw8psrmz 131 28 spike spike NN cord-002490-kw8psrmz 131 29 ( ( -LRB- cord-002490-kw8psrmz 131 30 Supplementary supplementary JJ cord-002490-kw8psrmz 131 31 Fig Fig NNP cord-002490-kw8psrmz 131 32 S2 s2 NN cord-002490-kw8psrmz 131 33 ) ) -RRB- cord-002490-kw8psrmz 131 34 . . . cord-002490-kw8psrmz 132 1 A a DT cord-002490-kw8psrmz 132 2 dual dual JJ cord-002490-kw8psrmz 132 3 set set NN cord-002490-kw8psrmz 132 4 images image NNS cord-002490-kw8psrmz 132 5 was be VBD cord-002490-kw8psrmz 132 6 then then RB cord-002490-kw8psrmz 132 7 sub sub NN cord-002490-kw8psrmz 132 8 - - HYPH cord-002490-kw8psrmz 132 9 filed file VBN cord-002490-kw8psrmz 132 10 , , , cord-002490-kw8psrmz 132 11 one one CD cord-002490-kw8psrmz 132 12 masked mask VBN cord-002490-kw8psrmz 132 13 with with IN cord-002490-kw8psrmz 132 14 the the DT cord-002490-kw8psrmz 132 15 " " `` cord-002490-kw8psrmz 132 16 T"-shaped t"-shaped CD cord-002490-kw8psrmz 132 17 mask mask NN cord-002490-kw8psrmz 132 18 , , , cord-002490-kw8psrmz 132 19 and and CC cord-002490-kw8psrmz 132 20 the the DT cord-002490-kw8psrmz 132 21 other other JJ cord-002490-kw8psrmz 132 22 unmasked unmask VBN cord-002490-kw8psrmz 132 23 . . . cord-002490-kw8psrmz 133 1 The the DT cord-002490-kw8psrmz 133 2 3D 3d JJ cord-002490-kw8psrmz 133 3 reconstruction reconstruction NN cord-002490-kw8psrmz 133 4 of of IN cord-002490-kw8psrmz 133 5 the the DT cord-002490-kw8psrmz 133 6 GP GP NNP cord-002490-kw8psrmz 133 7 spike spike NN cord-002490-kw8psrmz 133 8 was be VBD cord-002490-kw8psrmz 133 9 then then RB cord-002490-kw8psrmz 133 10 generated generate VBN cord-002490-kw8psrmz 133 11 by by IN cord-002490-kw8psrmz 133 12 projection projection NN cord-002490-kw8psrmz 133 13 matching matching NN cord-002490-kw8psrmz 133 14 , , , cord-002490-kw8psrmz 133 15 using use VBG cord-002490-kw8psrmz 133 16 methods method NNS cord-002490-kw8psrmz 133 17 similar similar JJ cord-002490-kw8psrmz 133 18 to to IN cord-002490-kw8psrmz 133 19 those those DT cord-002490-kw8psrmz 133 20 previously previously RB cord-002490-kw8psrmz 133 21 used use VBN cord-002490-kw8psrmz 133 22 with with IN cord-002490-kw8psrmz 133 23 other other JJ cord-002490-kw8psrmz 133 24 viral viral JJ cord-002490-kw8psrmz 133 25 spikes spike NNS cord-002490-kw8psrmz 133 26 within within IN cord-002490-kw8psrmz 133 27 their -PRON- PRP$ cord-002490-kw8psrmz 133 28 envelopes envelope NNS cord-002490-kw8psrmz 133 29 4,40 4,40 CD cord-002490-kw8psrmz 133 30 . . . cord-002490-kw8psrmz 134 1 The the DT cord-002490-kw8psrmz 134 2 main main JJ cord-002490-kw8psrmz 134 3 difference difference NN cord-002490-kw8psrmz 134 4 was be VBD cord-002490-kw8psrmz 134 5 the the DT cord-002490-kw8psrmz 134 6 use use NN cord-002490-kw8psrmz 134 7 of of IN cord-002490-kw8psrmz 134 8 " " `` cord-002490-kw8psrmz 134 9 T"-masked t"-masked CD cord-002490-kw8psrmz 134 10 images image NNS cord-002490-kw8psrmz 134 11 for for IN cord-002490-kw8psrmz 134 12 two two CD cord-002490-kw8psrmz 134 13 - - HYPH cord-002490-kw8psrmz 134 14 dimensional dimensional JJ cord-002490-kw8psrmz 134 15 analysis analysis NN cord-002490-kw8psrmz 134 16 and and CC cord-002490-kw8psrmz 134 17 alignment alignment NN cord-002490-kw8psrmz 134 18 , , , cord-002490-kw8psrmz 134 19 and and CC cord-002490-kw8psrmz 134 20 unmasked unmask VBN cord-002490-kw8psrmz 134 21 images image NNS cord-002490-kw8psrmz 134 22 to to TO cord-002490-kw8psrmz 134 23 apply apply VB cord-002490-kw8psrmz 134 24 the the DT cord-002490-kw8psrmz 134 25 alignment alignment NN cord-002490-kw8psrmz 134 26 parameters parameter NNS cord-002490-kw8psrmz 134 27 to to TO cord-002490-kw8psrmz 134 28 generate generate VB cord-002490-kw8psrmz 134 29 new new JJ cord-002490-kw8psrmz 134 30 image image NN cord-002490-kw8psrmz 134 31 averages average NNS cord-002490-kw8psrmz 134 32 . . . cord-002490-kw8psrmz 135 1 In in IN cord-002490-kw8psrmz 135 2 addition addition NN cord-002490-kw8psrmz 135 3 a a DT cord-002490-kw8psrmz 135 4 cylindrical cylindrical JJ cord-002490-kw8psrmz 135 5 mask mask NN cord-002490-kw8psrmz 135 6 was be VBD cord-002490-kw8psrmz 135 7 used use VBN cord-002490-kw8psrmz 135 8 on on IN cord-002490-kw8psrmz 135 9 the the DT cord-002490-kw8psrmz 135 10 3-D 3-d JJ cord-002490-kw8psrmz 135 11 reference reference NN cord-002490-kw8psrmz 135 12 volume volume NN cord-002490-kw8psrmz 135 13 . . . cord-002490-kw8psrmz 136 1 In in IN cord-002490-kw8psrmz 136 2 both both DT cord-002490-kw8psrmz 136 3 cases case NNS cord-002490-kw8psrmz 136 4 , , , cord-002490-kw8psrmz 136 5 the the DT cord-002490-kw8psrmz 136 6 2-D 2-d JJ cord-002490-kw8psrmz 136 7 and and CC cord-002490-kw8psrmz 136 8 3-D 3-d JJ cord-002490-kw8psrmz 136 9 masks mask NNS cord-002490-kw8psrmz 136 10 selected select VBD cord-002490-kw8psrmz 136 11 data datum NNS cord-002490-kw8psrmz 136 12 from from IN cord-002490-kw8psrmz 136 13 the the DT cord-002490-kw8psrmz 136 14 envelope envelope NN cord-002490-kw8psrmz 136 15 and and CC cord-002490-kw8psrmz 136 16 spike spike NN cord-002490-kw8psrmz 136 17 , , , cord-002490-kw8psrmz 136 18 and and CC cord-002490-kw8psrmz 136 19 suppressed suppress VBD cord-002490-kw8psrmz 136 20 noise noise NN cord-002490-kw8psrmz 136 21 from from IN cord-002490-kw8psrmz 136 22 adjacent adjacent JJ cord-002490-kw8psrmz 136 23 spikes spike NNS cord-002490-kw8psrmz 136 24 , , , cord-002490-kw8psrmz 136 25 as as IN cord-002490-kw8psrmz 136 26 illustrated illustrate VBN cord-002490-kw8psrmz 136 27 in in IN cord-002490-kw8psrmz 136 28 Supplementary Supplementary NNP cord-002490-kw8psrmz 136 29 Figs Figs NNP cord-002490-kw8psrmz 136 30 S2 S2 NNP cord-002490-kw8psrmz 136 31 and and CC cord-002490-kw8psrmz 136 32 S3 S3 NNP cord-002490-kw8psrmz 136 33 . . . cord-002490-kw8psrmz 137 1 Structure structure NN cord-002490-kw8psrmz 137 2 visualisation visualisation NN cord-002490-kw8psrmz 137 3 and and CC cord-002490-kw8psrmz 137 4 docking docking NN cord-002490-kw8psrmz 137 5 atomic atomic JJ cord-002490-kw8psrmz 137 6 resolution resolution NN cord-002490-kw8psrmz 137 7 data datum NNS cord-002490-kw8psrmz 137 8 . . . cord-002490-kw8psrmz 138 1 The the DT cord-002490-kw8psrmz 138 2 3D 3d JJ cord-002490-kw8psrmz 138 3 cryo cryo NN cord-002490-kw8psrmz 138 4 - - HYPH cord-002490-kw8psrmz 138 5 EM EM NNP cord-002490-kw8psrmz 138 6 data datum NNS cord-002490-kw8psrmz 138 7 , , , cord-002490-kw8psrmz 138 8 including include VBG cord-002490-kw8psrmz 138 9 docked dock VBN cord-002490-kw8psrmz 138 10 atomic atomic JJ cord-002490-kw8psrmz 138 11 resolution resolution NN cord-002490-kw8psrmz 138 12 structures structure NNS cord-002490-kw8psrmz 138 13 3CSY 3csy VBP cord-002490-kw8psrmz 138 14 , , , cord-002490-kw8psrmz 138 15 3X2D 3x2d CD cord-002490-kw8psrmz 138 16 , , , cord-002490-kw8psrmz 138 17 and and CC cord-002490-kw8psrmz 138 18 2EBO 2ebo CD cord-002490-kw8psrmz 138 19 were be VBD cord-002490-kw8psrmz 138 20 visualised visualise VBN cord-002490-kw8psrmz 138 21 with with IN cord-002490-kw8psrmz 138 22 the the DT cord-002490-kw8psrmz 138 23 Chimera Chimera NNP cord-002490-kw8psrmz 138 24 software software NN cord-002490-kw8psrmz 138 25 package package NN cord-002490-kw8psrmz 138 26 41 41 CD cord-002490-kw8psrmz 139 1 ( ( -LRB- cord-002490-kw8psrmz 139 2 Computer Computer NNP cord-002490-kw8psrmz 139 3 Graphics Graphics NNP cord-002490-kw8psrmz 139 4 Laboratory Laboratory NNP cord-002490-kw8psrmz 139 5 , , , cord-002490-kw8psrmz 139 6 University University NNP cord-002490-kw8psrmz 139 7 of of IN cord-002490-kw8psrmz 139 8 California California NNP cord-002490-kw8psrmz 139 9 , , , cord-002490-kw8psrmz 139 10 San San NNP cord-002490-kw8psrmz 139 11 Francisco Francisco NNP cord-002490-kw8psrmz 139 12 , , , cord-002490-kw8psrmz 139 13 supported support VBN cord-002490-kw8psrmz 139 14 by by IN cord-002490-kw8psrmz 139 15 NIH NIH NNP cord-002490-kw8psrmz 139 16 P41 P41 NNP cord-002490-kw8psrmz 139 17 RR-010810 rr-010810 NN cord-002490-kw8psrmz 139 18 ) ) -RRB- cord-002490-kw8psrmz 139 19 . . . cord-002490-kw8psrmz 140 1 Data datum NNS cord-002490-kw8psrmz 140 2 and and CC cord-002490-kw8psrmz 140 3 materials material NNS cord-002490-kw8psrmz 140 4 availability availability NN cord-002490-kw8psrmz 140 5 . . . cord-002490-kw8psrmz 141 1 The the DT cord-002490-kw8psrmz 141 2 3-D 3-d JJ cord-002490-kw8psrmz 141 3 electron electron NN cord-002490-kw8psrmz 141 4 microscopy microscopy NN cord-002490-kw8psrmz 141 5 structure structure NN cord-002490-kw8psrmz 141 6 of of IN cord-002490-kw8psrmz 141 7 the the DT cord-002490-kw8psrmz 141 8 GP GP NNP cord-002490-kw8psrmz 141 9 spike spike NN cord-002490-kw8psrmz 141 10 has have VBZ cord-002490-kw8psrmz 141 11 been be VBN cord-002490-kw8psrmz 141 12 deposited deposit VBN cord-002490-kw8psrmz 141 13 into into IN cord-002490-kw8psrmz 141 14 the the DT cord-002490-kw8psrmz 141 15 Electron Electron NNP cord-002490-kw8psrmz 141 16 Microscopy Microscopy NNP cord-002490-kw8psrmz 141 17 Data Data NNP cord-002490-kw8psrmz 141 18 Bank Bank NNP cord-002490-kw8psrmz 141 19 , , , cord-002490-kw8psrmz 141 20 www.emdatabank.org www.emdatabank.org NN cord-002490-kw8psrmz 142 1 ( ( -LRB- cord-002490-kw8psrmz 142 2 accession accession NN cord-002490-kw8psrmz 142 3 number number NN cord-002490-kw8psrmz 142 4 EMD-8630 EMD-8630 NNP cord-002490-kw8psrmz 142 5 ) ) -RRB- cord-002490-kw8psrmz 142 6 . . . cord-002490-kw8psrmz 143 1 Marburg Marburg NNP cord-002490-kw8psrmz 143 2 and and CC cord-002490-kw8psrmz 143 3 Ebola Ebola NNP cord-002490-kw8psrmz 143 4 viruses virus NNS cord-002490-kw8psrmz 143 5 . . . cord-002490-kw8psrmz 144 1 Fields field NNS cord-002490-kw8psrmz 144 2 virology virology NN cord-002490-kw8psrmz 144 3 Ebola Ebola NNP cord-002490-kw8psrmz 144 4 virus virus NN cord-002490-kw8psrmz 144 5 disease disease NN cord-002490-kw8psrmz 144 6 in in IN cord-002490-kw8psrmz 144 7 West West NNP cord-002490-kw8psrmz 144 8 Africa Africa NNP cord-002490-kw8psrmz 144 9 - - : cord-002490-kw8psrmz 144 10 the the DT cord-002490-kw8psrmz 144 11 first first JJ cord-002490-kw8psrmz 144 12 9 9 CD cord-002490-kw8psrmz 144 13 months month NNS cord-002490-kw8psrmz 144 14 of of IN cord-002490-kw8psrmz 144 15 the the DT cord-002490-kw8psrmz 144 16 epidemic epidemic NN cord-002490-kw8psrmz 144 17 and and CC cord-002490-kw8psrmz 144 18 forward forward JJ cord-002490-kw8psrmz 144 19 projections projection NNS cord-002490-kw8psrmz 144 20 Structural structural JJ cord-002490-kw8psrmz 144 21 rearrangement rearrangement NN cord-002490-kw8psrmz 144 22 of of IN cord-002490-kw8psrmz 144 23 ebola ebola NNP cord-002490-kw8psrmz 144 24 virus virus NN cord-002490-kw8psrmz 144 25 VP40 VP40 NNP cord-002490-kw8psrmz 144 26 begets beget VBZ cord-002490-kw8psrmz 144 27 multiple multiple JJ cord-002490-kw8psrmz 144 28 functions function NNS cord-002490-kw8psrmz 144 29 in in IN cord-002490-kw8psrmz 144 30 the the DT cord-002490-kw8psrmz 144 31 virus virus NN cord-002490-kw8psrmz 144 32 life life NN cord-002490-kw8psrmz 144 33 cycle cycle NN cord-002490-kw8psrmz 145 1 The the DT cord-002490-kw8psrmz 145 2 organisation organisation NN cord-002490-kw8psrmz 145 3 of of IN cord-002490-kw8psrmz 145 4 Ebola Ebola NNP cord-002490-kw8psrmz 145 5 virus virus NN cord-002490-kw8psrmz 145 6 reveals reveal VBZ cord-002490-kw8psrmz 145 7 a a DT cord-002490-kw8psrmz 145 8 capacity capacity NN cord-002490-kw8psrmz 145 9 for for IN cord-002490-kw8psrmz 145 10 extensive extensive JJ cord-002490-kw8psrmz 145 11 , , , cord-002490-kw8psrmz 145 12 modular modular JJ cord-002490-kw8psrmz 145 13 polyploidy polyploidy NN cord-002490-kw8psrmz 146 1 How how WRB cord-002490-kw8psrmz 146 2 do do VBP cord-002490-kw8psrmz 146 3 filovirus filovirus NN cord-002490-kw8psrmz 146 4 filaments filament NNS cord-002490-kw8psrmz 146 5 bend bend VB cord-002490-kw8psrmz 146 6 without without IN cord-002490-kw8psrmz 146 7 breaking break VBG cord-002490-kw8psrmz 146 8 ? ? . cord-002490-kw8psrmz 147 1 Cellular cellular JJ cord-002490-kw8psrmz 147 2 entry entry NN cord-002490-kw8psrmz 147 3 of of IN cord-002490-kw8psrmz 147 4 ebola ebola NNP cord-002490-kw8psrmz 147 5 virus virus NN cord-002490-kw8psrmz 147 6 involves involve VBZ cord-002490-kw8psrmz 147 7 uptake uptake NN cord-002490-kw8psrmz 147 8 by by IN cord-002490-kw8psrmz 147 9 a a DT cord-002490-kw8psrmz 147 10 macropinocytosis macropinocytosis NN cord-002490-kw8psrmz 147 11 - - HYPH cord-002490-kw8psrmz 147 12 like like JJ cord-002490-kw8psrmz 147 13 mechanism mechanism NN cord-002490-kw8psrmz 147 14 and and CC cord-002490-kw8psrmz 147 15 subsequent subsequent JJ cord-002490-kw8psrmz 147 16 trafficking trafficking NN cord-002490-kw8psrmz 147 17 through through IN cord-002490-kw8psrmz 147 18 early early JJ cord-002490-kw8psrmz 147 19 and and CC cord-002490-kw8psrmz 147 20 late late JJ cord-002490-kw8psrmz 147 21 endosomes endosome VBZ cord-002490-kw8psrmz 147 22 A a DT cord-002490-kw8psrmz 147 23 system system NN cord-002490-kw8psrmz 147 24 for for IN cord-002490-kw8psrmz 147 25 functional functional JJ cord-002490-kw8psrmz 147 26 analysis analysis NN cord-002490-kw8psrmz 147 27 of of IN cord-002490-kw8psrmz 147 28 Ebola Ebola NNP cord-002490-kw8psrmz 147 29 virus virus NN cord-002490-kw8psrmz 147 30 glycoprotein glycoprotein NN cord-002490-kw8psrmz 147 31 Ebola Ebola NNP cord-002490-kw8psrmz 147 32 virus virus NN cord-002490-kw8psrmz 147 33 enters enter VBZ cord-002490-kw8psrmz 147 34 host host NN cord-002490-kw8psrmz 147 35 cells cell NNS cord-002490-kw8psrmz 147 36 by by IN cord-002490-kw8psrmz 147 37 macropinocytosis macropinocytosis NNP cord-002490-kw8psrmz 147 38 and and CC cord-002490-kw8psrmz 147 39 clathrin clathrin NNP cord-002490-kw8psrmz 147 40 - - HYPH cord-002490-kw8psrmz 147 41 mediated mediate VBN cord-002490-kw8psrmz 147 42 endocytosis endocytosis NN cord-002490-kw8psrmz 147 43 Inhibition inhibition NN cord-002490-kw8psrmz 147 44 of of IN cord-002490-kw8psrmz 147 45 Ebola Ebola NNP cord-002490-kw8psrmz 147 46 virus virus NN cord-002490-kw8psrmz 147 47 glycoprotein glycoprotein NN cord-002490-kw8psrmz 147 48 - - HYPH cord-002490-kw8psrmz 147 49 mediated mediate VBN cord-002490-kw8psrmz 147 50 cytotoxicity cytotoxicity NN cord-002490-kw8psrmz 147 51 by by IN cord-002490-kw8psrmz 147 52 targeting target VBG cord-002490-kw8psrmz 147 53 its -PRON- PRP$ cord-002490-kw8psrmz 147 54 transmembrane transmembrane NN cord-002490-kw8psrmz 147 55 domain domain NN cord-002490-kw8psrmz 147 56 and and CC cord-002490-kw8psrmz 147 57 cholesterol cholesterol NN cord-002490-kw8psrmz 147 58 Ebola Ebola NNP cord-002490-kw8psrmz 147 59 virus virus NN cord-002490-kw8psrmz 147 60 entry entry NN cord-002490-kw8psrmz 147 61 requires require VBZ cord-002490-kw8psrmz 147 62 the the DT cord-002490-kw8psrmz 147 63 cholesterol cholesterol NN cord-002490-kw8psrmz 147 64 transporter transporter NN cord-002490-kw8psrmz 147 65 Niemann Niemann NNP cord-002490-kw8psrmz 147 66 - - HYPH cord-002490-kw8psrmz 147 67 Pick Pick NNP cord-002490-kw8psrmz 147 68 C1 C1 NNP cord-002490-kw8psrmz 147 69 Small small JJ cord-002490-kw8psrmz 147 70 molecule molecule NN cord-002490-kw8psrmz 147 71 inhibitors inhibitor NNS cord-002490-kw8psrmz 147 72 reveal reveal VBP cord-002490-kw8psrmz 147 73 Niemann Niemann NNP cord-002490-kw8psrmz 147 74 - - HYPH cord-002490-kw8psrmz 147 75 Pick Pick NNP cord-002490-kw8psrmz 147 76 C1 C1 NNP cord-002490-kw8psrmz 147 77 is be VBZ cord-002490-kw8psrmz 147 78 essential essential JJ cord-002490-kw8psrmz 147 79 for for IN cord-002490-kw8psrmz 147 80 Ebola Ebola NNP cord-002490-kw8psrmz 147 81 virus virus NN cord-002490-kw8psrmz 147 82 infection infection NN cord-002490-kw8psrmz 148 1 Ebolavirus Ebolavirus NNP cord-002490-kw8psrmz 148 2 is be VBZ cord-002490-kw8psrmz 148 3 internalized internalize VBN cord-002490-kw8psrmz 148 4 into into IN cord-002490-kw8psrmz 148 5 host host NN cord-002490-kw8psrmz 148 6 cells cell NNS cord-002490-kw8psrmz 148 7 via via IN cord-002490-kw8psrmz 148 8 macropinocytosis macropinocytosis NN cord-002490-kw8psrmz 148 9 in in IN cord-002490-kw8psrmz 148 10 a a DT cord-002490-kw8psrmz 148 11 viral viral JJ cord-002490-kw8psrmz 148 12 glycoprotein glycoprotein NN cord-002490-kw8psrmz 148 13 - - HYPH cord-002490-kw8psrmz 148 14 dependent dependent JJ cord-002490-kw8psrmz 148 15 manner manner NN cord-002490-kw8psrmz 149 1 Cross cross JJ cord-002490-kw8psrmz 149 2 - - JJ cord-002490-kw8psrmz 149 3 reactive reactive JJ cord-002490-kw8psrmz 149 4 and and CC cord-002490-kw8psrmz 149 5 potent potent JJ cord-002490-kw8psrmz 149 6 neutralizing neutralize VBG cord-002490-kw8psrmz 149 7 antibody antibody NN cord-002490-kw8psrmz 149 8 responses response NNS cord-002490-kw8psrmz 149 9 in in IN cord-002490-kw8psrmz 149 10 human human JJ cord-002490-kw8psrmz 149 11 survivors survivor NNS cord-002490-kw8psrmz 149 12 of of IN cord-002490-kw8psrmz 149 13 natural natural JJ cord-002490-kw8psrmz 149 14 Ebolavirus Ebolavirus NNP cord-002490-kw8psrmz 149 15 infection infection NN cord-002490-kw8psrmz 149 16 Toremifene Toremifene NNP cord-002490-kw8psrmz 149 17 interacts interact VBZ cord-002490-kw8psrmz 149 18 with with IN cord-002490-kw8psrmz 149 19 and and CC cord-002490-kw8psrmz 149 20 destabilizes destabilize VBZ cord-002490-kw8psrmz 149 21 the the DT cord-002490-kw8psrmz 149 22 Ebola Ebola NNP cord-002490-kw8psrmz 149 23 virus virus NN cord-002490-kw8psrmz 149 24 glycoprotein glycoprotein NN cord-002490-kw8psrmz 149 25 Structural structural JJ cord-002490-kw8psrmz 149 26 basis basis NN cord-002490-kw8psrmz 149 27 for for IN cord-002490-kw8psrmz 149 28 Marburg Marburg NNP cord-002490-kw8psrmz 149 29 virus virus NN cord-002490-kw8psrmz 149 30 neutralization neutralization NN cord-002490-kw8psrmz 149 31 by by IN cord-002490-kw8psrmz 149 32 a a DT cord-002490-kw8psrmz 149 33 cross cross JJ cord-002490-kw8psrmz 149 34 - - JJ cord-002490-kw8psrmz 149 35 reactive reactive JJ cord-002490-kw8psrmz 149 36 human human JJ cord-002490-kw8psrmz 149 37 antibody antibody NN cord-002490-kw8psrmz 149 38 Structures structure NNS cord-002490-kw8psrmz 149 39 of of IN cord-002490-kw8psrmz 149 40 protective protective JJ cord-002490-kw8psrmz 149 41 antibodies antibody NNS cord-002490-kw8psrmz 149 42 reveal reveal VBP cord-002490-kw8psrmz 149 43 sites site NNS cord-002490-kw8psrmz 149 44 of of IN cord-002490-kw8psrmz 149 45 vulnerability vulnerability NN cord-002490-kw8psrmz 149 46 on on IN cord-002490-kw8psrmz 149 47 Ebola Ebola NNP cord-002490-kw8psrmz 149 48 virus virus NN cord-002490-kw8psrmz 149 49 Biochemical biochemical JJ cord-002490-kw8psrmz 149 50 and and CC cord-002490-kw8psrmz 149 51 structural structural JJ cord-002490-kw8psrmz 149 52 characterization characterization NN cord-002490-kw8psrmz 149 53 of of IN cord-002490-kw8psrmz 149 54 cathepsin cathepsin NN cord-002490-kw8psrmz 149 55 L l NN cord-002490-kw8psrmz 149 56 - - HYPH cord-002490-kw8psrmz 149 57 processed process VBN cord-002490-kw8psrmz 149 58 Ebola Ebola NNP cord-002490-kw8psrmz 149 59 virus virus NN cord-002490-kw8psrmz 149 60 glycoprotein glycoprotein NN cord-002490-kw8psrmz 149 61 : : : cord-002490-kw8psrmz 149 62 implications implication NNS cord-002490-kw8psrmz 149 63 for for IN cord-002490-kw8psrmz 149 64 viral viral JJ cord-002490-kw8psrmz 149 65 entry entry NN cord-002490-kw8psrmz 149 66 and and CC cord-002490-kw8psrmz 149 67 immunogenicity immunogenicity NN cord-002490-kw8psrmz 149 68 Structure Structure NNP cord-002490-kw8psrmz 149 69 of of IN cord-002490-kw8psrmz 149 70 the the DT cord-002490-kw8psrmz 149 71 Ebola Ebola NNP cord-002490-kw8psrmz 149 72 virus virus NN cord-002490-kw8psrmz 149 73 glycoprotein glycoprotein NN cord-002490-kw8psrmz 149 74 bound bind VBN cord-002490-kw8psrmz 149 75 to to IN cord-002490-kw8psrmz 149 76 an an DT cord-002490-kw8psrmz 149 77 antibody antibody NN cord-002490-kw8psrmz 149 78 from from IN cord-002490-kw8psrmz 149 79 a a DT cord-002490-kw8psrmz 149 80 human human JJ cord-002490-kw8psrmz 149 81 survivor survivor NN cord-002490-kw8psrmz 149 82 Ebola Ebola NNP cord-002490-kw8psrmz 149 83 virus virus NN cord-002490-kw8psrmz 149 84 entry entry NN cord-002490-kw8psrmz 149 85 requires require VBZ cord-002490-kw8psrmz 149 86 the the DT cord-002490-kw8psrmz 149 87 host host NN cord-002490-kw8psrmz 149 88 - - HYPH cord-002490-kw8psrmz 149 89 programmed program VBN cord-002490-kw8psrmz 149 90 recognition recognition NN cord-002490-kw8psrmz 149 91 of of IN cord-002490-kw8psrmz 149 92 an an DT cord-002490-kw8psrmz 149 93 intracellular intracellular JJ cord-002490-kw8psrmz 149 94 receptor receptor NN cord-002490-kw8psrmz 149 95 Role role NN cord-002490-kw8psrmz 149 96 of of IN cord-002490-kw8psrmz 149 97 endosomal endosomal NNP cord-002490-kw8psrmz 149 98 cathepsins cathepsin NNS cord-002490-kw8psrmz 149 99 in in IN cord-002490-kw8psrmz 149 100 entry entry NN cord-002490-kw8psrmz 149 101 mediated mediate VBN cord-002490-kw8psrmz 149 102 by by IN cord-002490-kw8psrmz 149 103 the the DT cord-002490-kw8psrmz 149 104 Ebola Ebola NNP cord-002490-kw8psrmz 149 105 virus virus NN cord-002490-kw8psrmz 149 106 glycoprotein glycoprotein VBG cord-002490-kw8psrmz 149 107 Endosomal Endosomal NNP cord-002490-kw8psrmz 149 108 proteolysis proteolysis NN cord-002490-kw8psrmz 149 109 of of IN cord-002490-kw8psrmz 149 110 the the DT cord-002490-kw8psrmz 149 111 Ebola Ebola NNP cord-002490-kw8psrmz 149 112 virus virus NN cord-002490-kw8psrmz 149 113 glycoprotein glycoprotein NN cord-002490-kw8psrmz 149 114 is be VBZ cord-002490-kw8psrmz 149 115 necessary necessary JJ cord-002490-kw8psrmz 149 116 for for IN cord-002490-kw8psrmz 149 117 infection infection NN cord-002490-kw8psrmz 150 1 The the DT cord-002490-kw8psrmz 150 2 Primed primed JJ cord-002490-kw8psrmz 150 3 Ebolavirus Ebolavirus NNP cord-002490-kw8psrmz 150 4 Glycoprotein Glycoprotein NNP cord-002490-kw8psrmz 150 5 ( ( -LRB- cord-002490-kw8psrmz 150 6 19-Kilodalton 19-kilodalton CD cord-002490-kw8psrmz 150 7 GP1 gp1 NN cord-002490-kw8psrmz 150 8 , , , cord-002490-kw8psrmz 150 9 2 2 CD cord-002490-kw8psrmz 150 10 ) ) -RRB- cord-002490-kw8psrmz 150 11 : : : cord-002490-kw8psrmz 150 12 Sequence sequence NN cord-002490-kw8psrmz 150 13 and and CC cord-002490-kw8psrmz 150 14 Residues Residues NNP cord-002490-kw8psrmz 150 15 Critical Critical NNP cord-002490-kw8psrmz 150 16 for for IN cord-002490-kw8psrmz 150 17 Host Host NNP cord-002490-kw8psrmz 150 18 Cell Cell NNP cord-002490-kw8psrmz 150 19 Binding Binding NNP cord-002490-kw8psrmz 150 20 Role role NN cord-002490-kw8psrmz 150 21 of of IN cord-002490-kw8psrmz 150 22 EXT1 EXT1 NNP cord-002490-kw8psrmz 150 23 and and CC cord-002490-kw8psrmz 150 24 Glycosaminoglycans Glycosaminoglycans NNPS cord-002490-kw8psrmz 150 25 in in IN cord-002490-kw8psrmz 150 26 the the DT cord-002490-kw8psrmz 150 27 Early Early NNP cord-002490-kw8psrmz 150 28 Stage Stage NNP cord-002490-kw8psrmz 150 29 of of IN cord-002490-kw8psrmz 150 30 Filovirus Filovirus NNP cord-002490-kw8psrmz 150 31 Entry Entry NNP cord-002490-kw8psrmz 150 32 Core Core NNP cord-002490-kw8psrmz 150 33 structure structure NN cord-002490-kw8psrmz 150 34 of of IN cord-002490-kw8psrmz 150 35 the the DT cord-002490-kw8psrmz 150 36 envelope envelope NN cord-002490-kw8psrmz 150 37 glycoprotein glycoprotein NN cord-002490-kw8psrmz 150 38 GP2 GP2 NNP cord-002490-kw8psrmz 150 39 from from IN cord-002490-kw8psrmz 150 40 Ebola Ebola NNP cord-002490-kw8psrmz 150 41 virus virus NN cord-002490-kw8psrmz 150 42 at at IN cord-002490-kw8psrmz 150 43 1.9-A 1.9-a CD cord-002490-kw8psrmz 150 44 resolution resolution NN cord-002490-kw8psrmz 150 45 Structure structure NN cord-002490-kw8psrmz 150 46 and and CC cord-002490-kw8psrmz 150 47 orientation orientation NN cord-002490-kw8psrmz 150 48 study study NN cord-002490-kw8psrmz 150 49 of of IN cord-002490-kw8psrmz 150 50 Ebola Ebola NNP cord-002490-kw8psrmz 150 51 fusion fusion NN cord-002490-kw8psrmz 150 52 peptide peptide NN cord-002490-kw8psrmz 150 53 inserted insert VBN cord-002490-kw8psrmz 150 54 in in IN cord-002490-kw8psrmz 150 55 lipid lipid NN cord-002490-kw8psrmz 150 56 membrane membrane NN cord-002490-kw8psrmz 150 57 models model NNS cord-002490-kw8psrmz 150 58 Crystal Crystal NNP cord-002490-kw8psrmz 150 59 structure structure NN cord-002490-kw8psrmz 150 60 of of IN cord-002490-kw8psrmz 150 61 the the DT cord-002490-kw8psrmz 150 62 Ebola Ebola NNP cord-002490-kw8psrmz 150 63 virus virus NN cord-002490-kw8psrmz 150 64 membrane membrane NN cord-002490-kw8psrmz 150 65 fusion fusion NN cord-002490-kw8psrmz 150 66 subunit subunit NN cord-002490-kw8psrmz 150 67 , , , cord-002490-kw8psrmz 150 68 GP2 GP2 NNP cord-002490-kw8psrmz 150 69 , , , cord-002490-kw8psrmz 150 70 from from IN cord-002490-kw8psrmz 150 71 the the DT cord-002490-kw8psrmz 150 72 envelope envelope NN cord-002490-kw8psrmz 150 73 glycoprotein glycoprotein NN cord-002490-kw8psrmz 150 74 ectodomain ectodomain NNP cord-002490-kw8psrmz 151 1 The the DT cord-002490-kw8psrmz 151 2 creation creation NN cord-002490-kw8psrmz 151 3 of of IN cord-002490-kw8psrmz 151 4 stable stable JJ cord-002490-kw8psrmz 151 5 cell cell NN cord-002490-kw8psrmz 151 6 lines line NNS cord-002490-kw8psrmz 151 7 expressing express VBG cord-002490-kw8psrmz 151 8 Ebola Ebola NNP cord-002490-kw8psrmz 151 9 virus virus NN cord-002490-kw8psrmz 151 10 glycoproteins glycoprotein NNS cord-002490-kw8psrmz 151 11 and and CC cord-002490-kw8psrmz 151 12 the the DT cord-002490-kw8psrmz 151 13 matrix matrix NN cord-002490-kw8psrmz 151 14 protein protein NN cord-002490-kw8psrmz 151 15 VP40 VP40 NNP cord-002490-kw8psrmz 151 16 and and CC cord-002490-kw8psrmz 151 17 generating generate VBG cord-002490-kw8psrmz 151 18 Ebola Ebola NNP cord-002490-kw8psrmz 151 19 virus virus NN cord-002490-kw8psrmz 151 20 - - HYPH cord-002490-kw8psrmz 151 21 like like JJ cord-002490-kw8psrmz 151 22 particles particle NNS cord-002490-kw8psrmz 151 23 utilizing utilize VBG cord-002490-kw8psrmz 151 24 an an DT cord-002490-kw8psrmz 151 25 ecdysone ecdysone NN cord-002490-kw8psrmz 151 26 inducible inducible JJ cord-002490-kw8psrmz 151 27 mammalian mammalian JJ cord-002490-kw8psrmz 151 28 expression expression NN cord-002490-kw8psrmz 151 29 system system NN cord-002490-kw8psrmz 151 30 Spatial spatial JJ cord-002490-kw8psrmz 151 31 localization localization NN cord-002490-kw8psrmz 151 32 of of IN cord-002490-kw8psrmz 151 33 the the DT cord-002490-kw8psrmz 151 34 Ebola Ebola NNP cord-002490-kw8psrmz 151 35 virus virus NN cord-002490-kw8psrmz 151 36 glycoprotein glycoprotein NN cord-002490-kw8psrmz 151 37 mucin mucin NN cord-002490-kw8psrmz 151 38 - - HYPH cord-002490-kw8psrmz 151 39 like like JJ cord-002490-kw8psrmz 151 40 domain domain NN cord-002490-kw8psrmz 151 41 determined determine VBN cord-002490-kw8psrmz 151 42 by by IN cord-002490-kw8psrmz 151 43 cryo cryo NN cord-002490-kw8psrmz 151 44 - - HYPH cord-002490-kw8psrmz 151 45 electron electron NN cord-002490-kw8psrmz 151 46 tomography tomography NN cord-002490-kw8psrmz 151 47 Mapping mapping NN cord-002490-kw8psrmz 151 48 of of IN cord-002490-kw8psrmz 151 49 Ebolavirus Ebolavirus NNP cord-002490-kw8psrmz 151 50 Neutralization neutralization NN cord-002490-kw8psrmz 151 51 by by IN cord-002490-kw8psrmz 151 52 Monoclonal Monoclonal NNP cord-002490-kw8psrmz 151 53 Antibodies Antibodies NNPS cord-002490-kw8psrmz 151 54 in in IN cord-002490-kw8psrmz 151 55 the the DT cord-002490-kw8psrmz 151 56 ZMapp ZMapp NNP cord-002490-kw8psrmz 151 57 Cocktail Cocktail NNP cord-002490-kw8psrmz 151 58 Using use VBG cord-002490-kw8psrmz 151 59 Cryo Cryo NNP cord-002490-kw8psrmz 151 60 - - HYPH cord-002490-kw8psrmz 151 61 Electron Electron NNP cord-002490-kw8psrmz 151 62 Tomography Tomography NNP cord-002490-kw8psrmz 151 63 and and CC cord-002490-kw8psrmz 151 64 Studies Studies NNPS cord-002490-kw8psrmz 151 65 of of IN cord-002490-kw8psrmz 151 66 Cellular Cellular NNP cord-002490-kw8psrmz 151 67 Entry Entry NNP cord-002490-kw8psrmz 151 68 GraFix GraFix NNP cord-002490-kw8psrmz 151 69 : : : cord-002490-kw8psrmz 151 70 sample sample NN cord-002490-kw8psrmz 151 71 preparation preparation NN cord-002490-kw8psrmz 151 72 for for IN cord-002490-kw8psrmz 151 73 single single JJ cord-002490-kw8psrmz 151 74 - - HYPH cord-002490-kw8psrmz 151 75 particle particle NN cord-002490-kw8psrmz 151 76 electron electron NN cord-002490-kw8psrmz 151 77 cryomicroscopy cryomicroscopy NNP cord-002490-kw8psrmz 152 1 The the DT cord-002490-kw8psrmz 152 2 ribosome ribosome NN cord-002490-kw8psrmz 152 3 at at IN cord-002490-kw8psrmz 152 4 improved improved JJ cord-002490-kw8psrmz 152 5 resolution resolution NN cord-002490-kw8psrmz 152 6 : : : cord-002490-kw8psrmz 152 7 new new JJ cord-002490-kw8psrmz 152 8 techniques technique NNS cord-002490-kw8psrmz 152 9 for for IN cord-002490-kw8psrmz 152 10 merging merge VBG cord-002490-kw8psrmz 152 11 and and CC cord-002490-kw8psrmz 152 12 orientation orientation NN cord-002490-kw8psrmz 152 13 refinement refinement NN cord-002490-kw8psrmz 152 14 in in IN cord-002490-kw8psrmz 152 15 3D 3d JJ cord-002490-kw8psrmz 152 16 cryo cryo NN cord-002490-kw8psrmz 152 17 - - HYPH cord-002490-kw8psrmz 152 18 electron electron NN cord-002490-kw8psrmz 152 19 microscopy microscopy NN cord-002490-kw8psrmz 152 20 of of IN cord-002490-kw8psrmz 152 21 biological biological JJ cord-002490-kw8psrmz 152 22 particles particle NNS cord-002490-kw8psrmz 152 23 Optimal optimal JJ cord-002490-kw8psrmz 152 24 determination determination NN cord-002490-kw8psrmz 152 25 of of IN cord-002490-kw8psrmz 152 26 particle particle NN cord-002490-kw8psrmz 152 27 orientation orientation NN cord-002490-kw8psrmz 152 28 , , , cord-002490-kw8psrmz 152 29 absolute absolute JJ cord-002490-kw8psrmz 152 30 hand hand NN cord-002490-kw8psrmz 152 31 , , , cord-002490-kw8psrmz 152 32 and and CC cord-002490-kw8psrmz 152 33 contrast contrast NN cord-002490-kw8psrmz 152 34 loss loss NN cord-002490-kw8psrmz 152 35 in in IN cord-002490-kw8psrmz 152 36 single single JJ cord-002490-kw8psrmz 152 37 - - HYPH cord-002490-kw8psrmz 152 38 particle particle NN cord-002490-kw8psrmz 152 39 electron electron NN cord-002490-kw8psrmz 152 40 cryomicroscopy cryomicroscopy NN cord-002490-kw8psrmz 152 41 GP GP NNP cord-002490-kw8psrmz 152 42 mRNA mrna NN cord-002490-kw8psrmz 152 43 of of IN cord-002490-kw8psrmz 152 44 Ebola Ebola NNP cord-002490-kw8psrmz 152 45 Virus Virus NNP cord-002490-kw8psrmz 152 46 Is be VBZ cord-002490-kw8psrmz 152 47 Edited edit VBN cord-002490-kw8psrmz 152 48 by by IN cord-002490-kw8psrmz 152 49 the the DT cord-002490-kw8psrmz 152 50 Ebola Ebola NNP cord-002490-kw8psrmz 152 51 Virus Virus NNP cord-002490-kw8psrmz 152 52 Polymerase Polymerase NNP cord-002490-kw8psrmz 152 53 and and CC cord-002490-kw8psrmz 152 54 by by IN cord-002490-kw8psrmz 152 55 T7 T7 NNP cord-002490-kw8psrmz 152 56 and and CC cord-002490-kw8psrmz 152 57 Vaccinia Vaccinia NNP cord-002490-kw8psrmz 152 58 Virus Virus NNP cord-002490-kw8psrmz 152 59 Polymerases Polymerases NNP cord-002490-kw8psrmz 152 60 1 1 CD cord-002490-kw8psrmz 153 1 The the DT cord-002490-kw8psrmz 153 2 potential potential NN cord-002490-kw8psrmz 153 3 and and CC cord-002490-kw8psrmz 153 4 limitations limitation NNS cord-002490-kw8psrmz 153 5 of of IN cord-002490-kw8psrmz 153 6 neutrons neutron NNS cord-002490-kw8psrmz 153 7 , , , cord-002490-kw8psrmz 153 8 electrons electron NNS cord-002490-kw8psrmz 153 9 and and CC cord-002490-kw8psrmz 153 10 X X NNS cord-002490-kw8psrmz 153 11 - - NNS cord-002490-kw8psrmz 153 12 rays ray NNS cord-002490-kw8psrmz 153 13 for for IN cord-002490-kw8psrmz 153 14 atomic atomic JJ cord-002490-kw8psrmz 153 15 resolution resolution NN cord-002490-kw8psrmz 153 16 microscopy microscopy NNS cord-002490-kw8psrmz 153 17 of of IN cord-002490-kw8psrmz 153 18 unstained unstained JJ cord-002490-kw8psrmz 153 19 biological biological JJ cord-002490-kw8psrmz 153 20 molecules molecule NNS cord-002490-kw8psrmz 153 21 Structure Structure NNP cord-002490-kw8psrmz 153 22 of of IN cord-002490-kw8psrmz 153 23 glycosylated glycosylate VBN cord-002490-kw8psrmz 153 24 NPC1 NPC1 NNP cord-002490-kw8psrmz 153 25 luminal luminal JJ cord-002490-kw8psrmz 153 26 domain domain NN cord-002490-kw8psrmz 153 27 C c NN cord-002490-kw8psrmz 153 28 reveals reveal VBZ cord-002490-kw8psrmz 153 29 insights insight NNS cord-002490-kw8psrmz 153 30 into into IN cord-002490-kw8psrmz 154 1 NPC2 NPC2 NNP cord-002490-kw8psrmz 154 2 and and CC cord-002490-kw8psrmz 154 3 Ebola Ebola NNP cord-002490-kw8psrmz 154 4 virus virus NN cord-002490-kw8psrmz 154 5 interactions interaction VBZ cord-002490-kw8psrmz 154 6 Structural structural JJ cord-002490-kw8psrmz 154 7 Insights Insights NNPS cord-002490-kw8psrmz 154 8 into into IN cord-002490-kw8psrmz 154 9 the the DT cord-002490-kw8psrmz 154 10 Niemann Niemann NNP cord-002490-kw8psrmz 154 11 - - HYPH cord-002490-kw8psrmz 154 12 Pick Pick NNP cord-002490-kw8psrmz 154 13 C1 C1 NNP cord-002490-kw8psrmz 154 14 ( ( -LRB- cord-002490-kw8psrmz 154 15 NPC1)-Mediated NPC1)-Mediated NNP cord-002490-kw8psrmz 154 16 Cholesterol Cholesterol NNP cord-002490-kw8psrmz 154 17 Transfer Transfer NNP cord-002490-kw8psrmz 154 18 and and CC cord-002490-kw8psrmz 154 19 Ebola Ebola NNP cord-002490-kw8psrmz 154 20 Infection Infection NNP cord-002490-kw8psrmz 154 21 Replication replication NN cord-002490-kw8psrmz 154 22 - - HYPH cord-002490-kw8psrmz 154 23 deficient deficient JJ cord-002490-kw8psrmz 154 24 ebolavirus ebolavirus NN cord-002490-kw8psrmz 154 25 as as IN cord-002490-kw8psrmz 154 26 a a DT cord-002490-kw8psrmz 154 27 vaccine vaccine NN cord-002490-kw8psrmz 154 28 candidate candidate NN cord-002490-kw8psrmz 154 29 EMAN EMAN NNP cord-002490-kw8psrmz 154 30 : : : cord-002490-kw8psrmz 155 1 semiautomated semiautomated JJ cord-002490-kw8psrmz 155 2 software software NN cord-002490-kw8psrmz 155 3 for for IN cord-002490-kw8psrmz 155 4 high high JJ cord-002490-kw8psrmz 155 5 - - HYPH cord-002490-kw8psrmz 155 6 resolution resolution NN cord-002490-kw8psrmz 155 7 single single JJ cord-002490-kw8psrmz 155 8 - - HYPH cord-002490-kw8psrmz 155 9 particle particle NN cord-002490-kw8psrmz 155 10 reconstructions reconstruction NNS cord-002490-kw8psrmz 155 11 SPIDER spider NN cord-002490-kw8psrmz 155 12 and and CC cord-002490-kw8psrmz 155 13 WEB web NN cord-002490-kw8psrmz 155 14 : : : cord-002490-kw8psrmz 155 15 processing processing NN cord-002490-kw8psrmz 155 16 and and CC cord-002490-kw8psrmz 155 17 visualization visualization NN cord-002490-kw8psrmz 155 18 of of IN cord-002490-kw8psrmz 155 19 images image NNS cord-002490-kw8psrmz 155 20 in in IN cord-002490-kw8psrmz 155 21 3D 3d JJ cord-002490-kw8psrmz 155 22 electron electron NN cord-002490-kw8psrmz 155 23 microscopy microscopy NNS cord-002490-kw8psrmz 155 24 and and CC cord-002490-kw8psrmz 155 25 related relate VBN cord-002490-kw8psrmz 155 26 fields field NNS cord-002490-kw8psrmz 155 27 Architecture Architecture NNP cord-002490-kw8psrmz 155 28 of of IN cord-002490-kw8psrmz 156 1 the the DT cord-002490-kw8psrmz 156 2 SARS SARS NNP cord-002490-kw8psrmz 156 3 coronavirus coronavirus NN cord-002490-kw8psrmz 156 4 prefusion prefusion NN cord-002490-kw8psrmz 156 5 spike spike VBP cord-002490-kw8psrmz 156 6 UCSF UCSF NNP cord-002490-kw8psrmz 156 7 Chimera Chimera NNP cord-002490-kw8psrmz 156 8 - - : cord-002490-kw8psrmz 156 9 a a DT cord-002490-kw8psrmz 156 10 visualization visualization NN cord-002490-kw8psrmz 156 11 system system NN cord-002490-kw8psrmz 156 12 for for IN cord-002490-kw8psrmz 156 13 exploratory exploratory JJ cord-002490-kw8psrmz 156 14 research research NN cord-002490-kw8psrmz 156 15 and and CC cord-002490-kw8psrmz 156 16 analysis analysis NN cord-002490-kw8psrmz 157 1 We -PRON- PRP cord-002490-kw8psrmz 157 2 would would MD cord-002490-kw8psrmz 157 3 like like VB cord-002490-kw8psrmz 157 4 to to TO cord-002490-kw8psrmz 157 5 thank thank VB cord-002490-kw8psrmz 157 6 the the DT cord-002490-kw8psrmz 157 7 Canadian Canadian NNP cord-002490-kw8psrmz 157 8 Government Government NNP cord-002490-kw8psrmz 157 9 Genomics Genomics NNPS cord-002490-kw8psrmz 157 10 Research Research NNP cord-002490-kw8psrmz 157 11 and and CC cord-002490-kw8psrmz 157 12 Development Development NNP cord-002490-kw8psrmz 157 13 Initiative Initiative NNP cord-002490-kw8psrmz 157 14 for for IN cord-002490-kw8psrmz 157 15 funding funding NN cord-002490-kw8psrmz 157 16 , , , cord-002490-kw8psrmz 157 17 Dr. Dr. NNP cord-002490-kw8psrmz 157 18 Steven Steven NNP cord-002490-kw8psrmz 157 19 Jones Jones NNP cord-002490-kw8psrmz 157 20 ( ( -LRB- cord-002490-kw8psrmz 157 21 National National NNP cord-002490-kw8psrmz 157 22 Microbiology Microbiology NNP cord-002490-kw8psrmz 157 23 Laboratory Laboratory NNP cord-002490-kw8psrmz 157 24 , , , cord-002490-kw8psrmz 157 25 Canada Canada NNP cord-002490-kw8psrmz 157 26 ) ) -RRB- cord-002490-kw8psrmz 157 27 for for IN cord-002490-kw8psrmz 157 28 providing provide VBG cord-002490-kw8psrmz 157 29 us -PRON- PRP cord-002490-kw8psrmz 157 30 with with IN cord-002490-kw8psrmz 157 31 EBOV EBOV NNP cord-002490-kw8psrmz 157 32 and and CC cord-002490-kw8psrmz 157 33 Shannon Shannon NNP cord-002490-kw8psrmz 157 34 Hiebert Hiebert NNP cord-002490-kw8psrmz 157 35 for for IN cord-002490-kw8psrmz 157 36 excellent excellent JJ cord-002490-kw8psrmz 157 37 technical technical JJ cord-002490-kw8psrmz 157 38 assistance assistance NN cord-002490-kw8psrmz 157 39 . . .