id	sid	tid	token	lemma	pos
cord-001835-0s7ok4uw	1	1	key	key	JJ
cord-001835-0s7ok4uw	1	2	:	:	:
cord-001835-0s7ok4uw	1	3	cord-001835	cord-001835	NNP
cord-001835-0s7ok4uw	1	4	-	-	HYPH
cord-001835-0s7ok4uw	1	5	0s7ok4uw	0s7ok4uw	CD
cord-001835-0s7ok4uw	1	6	authors	author	NNS
cord-001835-0s7ok4uw	1	7	:	:	:
cord-001835-0s7ok4uw	2	1	nan	nan	NNP
cord-001835-0s7ok4uw	2	2	title	title	NN
cord-001835-0s7ok4uw	2	3	:	:	:
cord-001835-0s7ok4uw	2	4	Abstracts	abstract	NNS
cord-001835-0s7ok4uw	2	5	of	of	IN
cord-001835-0s7ok4uw	2	6	the	the	DT
cord-001835-0s7ok4uw	2	7	29th	29th	JJ
cord-001835-0s7ok4uw	2	8	Annual	Annual	NNP
cord-001835-0s7ok4uw	2	9	Symposium	Symposium	NNP
cord-001835-0s7ok4uw	2	10	of	of	IN
cord-001835-0s7ok4uw	2	11	The	the	DT
cord-001835-0s7ok4uw	2	12	Protein	Protein	NNP
cord-001835-0s7ok4uw	2	13	Society	Society	NNP
cord-001835-0s7ok4uw	2	14	date	date	NN
cord-001835-0s7ok4uw	2	15	:	:	:
cord-001835-0s7ok4uw	2	16	2015	2015	CD
cord-001835-0s7ok4uw	2	17	-	-	SYM
cord-001835-0s7ok4uw	2	18	10	10	CD
cord-001835-0s7ok4uw	2	19	-	-	HYPH
cord-001835-0s7ok4uw	2	20	01	01	CD
cord-001835-0s7ok4uw	2	21	journal	journal	NN
cord-001835-0s7ok4uw	2	22	:	:	:
cord-001835-0s7ok4uw	3	1	Protein	protein	NN
cord-001835-0s7ok4uw	3	2	Science	science	NN
cord-001835-0s7ok4uw	3	3	DOI	doi	NN
cord-001835-0s7ok4uw	3	4	:	:	:
cord-001835-0s7ok4uw	4	1	10.1002	10.1002	CD
cord-001835-0s7ok4uw	4	2	/	/	SYM
cord-001835-0s7ok4uw	4	3	pro.2823	pro.2823	NN
cord-001835-0s7ok4uw	4	4	sha	sha	NNP
cord-001835-0s7ok4uw	4	5	:	:	:
cord-001835-0s7ok4uw	5	1	f3a7dafa9d2ebe778d132954b42fb96fcf45d5e0	f3a7dafa9d2ebe778d132954b42fb96fcf45d5e0	NNP
cord-001835-0s7ok4uw	5	2	doc_id	doc_id	CD
cord-001835-0s7ok4uw	6	1	:	:	:
cord-001835-0s7ok4uw	6	2	1835	1835	CD
cord-001835-0s7ok4uw	6	3	cord_uid	cord_uid	NNS
cord-001835-0s7ok4uw	6	4	:	:	:
cord-001835-0s7ok4uw	7	1	0s7ok4uw	0s7ok4uw	NNP
cord-001835-0s7ok4uw	7	2	nan	nan	NNP
cord-001835-0s7ok4uw	7	3	C	C	NNP
cord-001835-0s7ok4uw	7	4	-	-	HYPH
cord-001835-0s7ok4uw	7	5	terminus	terminus	NN
cord-001835-0s7ok4uw	7	6	glutamine	glutamine	NN
cord-001835-0s7ok4uw	7	7	-	-	HYPH
cord-001835-0s7ok4uw	7	8	rich	rich	JJ
cord-001835-0s7ok4uw	7	9	sequence	sequence	NN
cord-001835-0s7ok4uw	7	10	deleted	delete	VBN
cord-001835-0s7ok4uw	7	11	)	)	-RRB-
cord-001835-0s7ok4uw	7	12	to	to	TO
cord-001835-0s7ok4uw	7	13	elucidate	elucidate	VB
cord-001835-0s7ok4uw	7	14	the	the	DT
cord-001835-0s7ok4uw	7	15	role	role	NN
cord-001835-0s7ok4uw	7	16	of	of	IN
cord-001835-0s7ok4uw	7	17	metalloprotein	metalloprotein	NNP
cord-001835-0s7ok4uw	7	18	Hpn	Hpn	NNP
cord-001835-0s7ok4uw	7	19	-	-	HYPH
cord-001835-0s7ok4uw	7	20	like	like	JJ
cord-001835-0s7ok4uw	7	21	by	by	IN
cord-001835-0s7ok4uw	7	22	Fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	7	23	Resonance	Resonance	NNP
cord-001835-0s7ok4uw	7	24	Energy	Energy	NNP
cord-001835-0s7ok4uw	7	25	Transfer	Transfer	NNP
cord-001835-0s7ok4uw	7	26	(	(	-LRB-
cord-001835-0s7ok4uw	7	27	FRET	fret	NN
cord-001835-0s7ok4uw	7	28	)	)	-RRB-
cord-001835-0s7ok4uw	8	1	(	(	-LRB-
cord-001835-0s7ok4uw	8	2	Figure	figure	NN
cord-001835-0s7ok4uw	8	3	2	2	CD
cord-001835-0s7ok4uw	8	4	)	)	-RRB-
cord-001835-0s7ok4uw	8	5	[	[	-LRB-
cord-001835-0s7ok4uw	8	6	2	2	CD
cord-001835-0s7ok4uw	8	7	]	]	-RRB-
cord-001835-0s7ok4uw	8	8	.	.	.
cord-001835-0s7ok4uw	9	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	9	2	found	find	VBD
cord-001835-0s7ok4uw	9	3	the	the	DT
cord-001835-0s7ok4uw	9	4	selective	selective	JJ
cord-001835-0s7ok4uw	9	5	coordination	coordination	NN
cord-001835-0s7ok4uw	9	6	of	of	IN
cord-001835-0s7ok4uw	9	7	Ni(II	ni(ii	NN
cord-001835-0s7ok4uw	9	8	)	)	-RRB-
cord-001835-0s7ok4uw	9	9	and	and	CC
cord-001835-0s7ok4uw	9	10	Zn(II	zn(ii	NN
cord-001835-0s7ok4uw	9	11	)	)	-RRB-
cord-001835-0s7ok4uw	9	12	to	to	IN
cord-001835-0s7ok4uw	9	13	the	the	DT
cord-001835-0s7ok4uw	9	14	purified	purify	VBN
cord-001835-0s7ok4uw	9	15	sensors	sensor	NNS
cord-001835-0s7ok4uw	9	16	and	and	CC
cord-001835-0s7ok4uw	9	17	in	in	IN
cord-001835-0s7ok4uw	9	18	E.	E.	NNP
cord-001835-0s7ok4uw	9	19	coli	coli	NNS
cord-001835-0s7ok4uw	9	20	cells	cell	NNS
cord-001835-0s7ok4uw	9	21	.	.	.
cord-001835-0s7ok4uw	10	1	Surprisingly	surprisingly	RB
cord-001835-0s7ok4uw	10	2	,	,	,
cord-001835-0s7ok4uw	10	3	specific	specific	JJ
cord-001835-0s7ok4uw	10	4	interaction	interaction	NN
cord-001835-0s7ok4uw	10	5	between	between	IN
cord-001835-0s7ok4uw	10	6	the	the	DT
cord-001835-0s7ok4uw	10	7	FRET	fret	NN
cord-001835-0s7ok4uw	10	8	sensors	sensor	NNS
cord-001835-0s7ok4uw	10	9	and	and	CC
cord-001835-0s7ok4uw	10	10	Bi(III	Bi(III	NNP
cord-001835-0s7ok4uw	10	11	)	)	-RRB-
cord-001835-0s7ok4uw	10	12	was	be	VBD
cord-001835-0s7ok4uw	10	13	observed	observe	VBN
cord-001835-0s7ok4uw	10	14	.	.	.
cord-001835-0s7ok4uw	11	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	11	2	FRET	FRET	NNP
cord-001835-0s7ok4uw	11	3	analysis	analysis	NN
cord-001835-0s7ok4uw	11	4	confirmed	confirm	VBD
cord-001835-0s7ok4uw	11	5	the	the	DT
cord-001835-0s7ok4uw	11	6	role	role	NN
cord-001835-0s7ok4uw	11	7	of	of	IN
cord-001835-0s7ok4uw	11	8	Hpnl	Hpnl	NNP
cord-001835-0s7ok4uw	11	9	for	for	IN
cord-001835-0s7ok4uw	11	10	Ni(II	Ni(II	NNP
cord-001835-0s7ok4uw	11	11	)	)	-RRB-
cord-001835-0s7ok4uw	11	12	storage	storage	NN
cord-001835-0s7ok4uw	11	13	and	and	CC
cord-001835-0s7ok4uw	11	14	revealed	reveal	VBD
cord-001835-0s7ok4uw	11	15	the	the	DT
cord-001835-0s7ok4uw	11	16	potential	potential	JJ
cord-001835-0s7ok4uw	11	17	association	association	NN
cord-001835-0s7ok4uw	11	18	of	of	IN
cord-001835-0s7ok4uw	11	19	Hpnl	Hpnl	NNP
cord-001835-0s7ok4uw	11	20	with	with	IN
cord-001835-0s7ok4uw	11	21	Bi	Bi	NNP
cord-001835-0s7ok4uw	11	22	-	-	HYPH
cord-001835-0s7ok4uw	11	23	based	base	VBN
cord-001835-0s7ok4uw	11	24	antiulcer	antiulcer	NN
cord-001835-0s7ok4uw	11	25	drugs	drug	NNS
cord-001835-0s7ok4uw	11	26	in	in	IN
cord-001835-0s7ok4uw	11	27	cells	cell	NNS
cord-001835-0s7ok4uw	11	28	.	.	.
cord-001835-0s7ok4uw	12	1	PB-006	PB-006	NNP
cord-001835-0s7ok4uw	13	1	RNA	RNA	NNP
cord-001835-0s7ok4uw	13	2	Fate	Fate	NNP
cord-001835-0s7ok4uw	13	3	is	be	VBZ
cord-001835-0s7ok4uw	13	4	Controlled	control	VBN
cord-001835-0s7ok4uw	13	5	by	by	IN
cord-001835-0s7ok4uw	13	6	Highly	highly	RB
cord-001835-0s7ok4uw	13	7	-	-	HYPH
cord-001835-0s7ok4uw	13	8	Regulated	regulate	VBN
cord-001835-0s7ok4uw	13	9	RNA	RNA	NNP
cord-001835-0s7ok4uw	13	10	Binding	Binding	NNP
cord-001835-0s7ok4uw	13	11	Proteins	Proteins	NNP
cord-001835-0s7ok4uw	13	12	molecular	molecular	JJ
cord-001835-0s7ok4uw	13	13	mechanism	mechanism	NN
cord-001835-0s7ok4uw	13	14	that	that	WDT
cord-001835-0s7ok4uw	13	15	links	link	VBZ
cord-001835-0s7ok4uw	13	16	the	the	DT
cord-001835-0s7ok4uw	13	17	mRNA	mrna	NN
cord-001835-0s7ok4uw	13	18	-	-	HYPH
cord-001835-0s7ok4uw	13	19	degradation	degradation	NN
cord-001835-0s7ok4uw	13	20	pathway	pathway	NN
cord-001835-0s7ok4uw	13	21	with	with	IN
cord-001835-0s7ok4uw	13	22	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	13	23	signaling	signal	VBG
cord-001835-0s7ok4uw	13	24	networks	network	NNS
cord-001835-0s7ok4uw	13	25	through	through	IN
cord-001835-0s7ok4uw	13	26	the	the	DT
cord-001835-0s7ok4uw	13	27	reversible	reversible	JJ
cord-001835-0s7ok4uw	13	28	unfolding	unfolding	NN
cord-001835-0s7ok4uw	13	29	of	of	IN
cord-001835-0s7ok4uw	13	30	a	a	DT
cord-001835-0s7ok4uw	13	31	RNA	RNA	NNP
cord-001835-0s7ok4uw	13	32	binding	binding	NN
cord-001835-0s7ok4uw	13	33	domain	domain	NN
cord-001835-0s7ok4uw	13	34	(	(	-LRB-
cord-001835-0s7ok4uw	13	35	RBD	RBD	NNP
cord-001835-0s7ok4uw	13	36	)	)	-RRB-
cord-001835-0s7ok4uw	13	37	.	.	.
cord-001835-0s7ok4uw	14	1	RNA	RNA	NNP
cord-001835-0s7ok4uw	14	2	binding	binding	NN
cord-001835-0s7ok4uw	14	3	is	be	VBZ
cord-001835-0s7ok4uw	14	4	also	also	RB
cord-001835-0s7ok4uw	14	5	controlled	control	VBN
cord-001835-0s7ok4uw	14	6	by	by	IN
cord-001835-0s7ok4uw	14	7	pH	pH	NNP
cord-001835-0s7ok4uw	14	8	conditions	condition	NNS
cord-001835-0s7ok4uw	14	9	.	.	.
cord-001835-0s7ok4uw	15	1	This	this	DT
cord-001835-0s7ok4uw	15	2	finding	finding	NN
cord-001835-0s7ok4uw	15	3	becomes	become	VBZ
cord-001835-0s7ok4uw	15	4	relevant	relevant	JJ
cord-001835-0s7ok4uw	15	5	for	for	IN
cord-001835-0s7ok4uw	15	6	RBPs	rbps	NN
cord-001835-0s7ok4uw	15	7	such	such	JJ
cord-001835-0s7ok4uw	15	8	as	as	IN
cord-001835-0s7ok4uw	15	9	T	t	NN
cord-001835-0s7ok4uw	15	10	-	-	HYPH
cord-001835-0s7ok4uw	15	11	cell	cell	NN
cord-001835-0s7ok4uw	15	12	Intracellular	Intracellular	NNP
cord-001835-0s7ok4uw	15	13	Antigen	Antigen	NNP
cord-001835-0s7ok4uw	15	14	1	1	CD
cord-001835-0s7ok4uw	15	15	(	(	-LRB-
cord-001835-0s7ok4uw	15	16	TIA-1	TIA-1	NNP
cord-001835-0s7ok4uw	15	17	)	)	-RRB-
cord-001835-0s7ok4uw	15	18	,	,	,
cord-001835-0s7ok4uw	15	19	which	which	WDT
cord-001835-0s7ok4uw	15	20	shuttles	shuttle	VBZ
cord-001835-0s7ok4uw	15	21	between	between	IN
cord-001835-0s7ok4uw	15	22	two	two	CD
cord-001835-0s7ok4uw	15	23	cellular	cellular	JJ
cord-001835-0s7ok4uw	15	24	compartments	compartment	NNS
cord-001835-0s7ok4uw	15	25	(	(	-LRB-
cord-001835-0s7ok4uw	15	26	nucleus	nucleus	NN
cord-001835-0s7ok4uw	15	27	and	and	CC
cord-001835-0s7ok4uw	15	28	cytoplasm	cytoplasm	JJ
cord-001835-0s7ok4uw	15	29	)	)	-RRB-
cord-001835-0s7ok4uw	15	30	with	with	IN
cord-001835-0s7ok4uw	15	31	slightly	slightly	RB
cord-001835-0s7ok4uw	15	32	different	different	JJ
cord-001835-0s7ok4uw	15	33	pH	ph	NN
cord-001835-0s7ok4uw	15	34	values	value	NNS
cord-001835-0s7ok4uw	15	35	.	.	.
cord-001835-0s7ok4uw	16	1	In	in	IN
cord-001835-0s7ok4uw	16	2	fact	fact	NN
cord-001835-0s7ok4uw	16	3	,	,	,
cord-001835-0s7ok4uw	16	4	RNA	RNA	NNP
cord-001835-0s7ok4uw	16	5	binding	bind	VBG
cord-001835-0s7ok4uw	16	6	by	by	IN
cord-001835-0s7ok4uw	16	7	TIA-1	TIA-1	NNP
cord-001835-0s7ok4uw	16	8	is	be	VBZ
cord-001835-0s7ok4uw	16	9	modulated	modulate	VBN
cord-001835-0s7ok4uw	16	10	by	by	IN
cord-001835-0s7ok4uw	16	11	slight	slight	JJ
cord-001835-0s7ok4uw	16	12	environmental	environmental	JJ
cord-001835-0s7ok4uw	16	13	pH	ph	NN
cord-001835-0s7ok4uw	16	14	changes	change	NNS
cord-001835-0s7ok4uw	16	15	due	due	JJ
cord-001835-0s7ok4uw	16	16	to	to	IN
cord-001835-0s7ok4uw	16	17	the	the	DT
cord-001835-0s7ok4uw	16	18	protonation	protonation	NN
cord-001835-0s7ok4uw	16	19	/	/	SYM
cord-001835-0s7ok4uw	16	20	deprotonation	deprotonation	NN
cord-001835-0s7ok4uw	16	21	of	of	IN
cord-001835-0s7ok4uw	16	22	TIA-1	TIA-1	NNP
cord-001835-0s7ok4uw	16	23	histidine	histidine	NN
cord-001835-0s7ok4uw	16	24	residues	residue	NNS
cord-001835-0s7ok4uw	16	25	[	[	-LRB-
cord-001835-0s7ok4uw	16	26	3	3	CD
cord-001835-0s7ok4uw	16	27	,	,	,
cord-001835-0s7ok4uw	16	28	4	4	CD
cord-001835-0s7ok4uw	16	29	]	]	-RRB-
cord-001835-0s7ok4uw	16	30	.	.	.
cord-001835-0s7ok4uw	17	1	The	the	DT
cord-001835-0s7ok4uw	17	2	pH	pH	NNP
cord-001835-0s7ok4uw	17	3	dependence	dependence	NN
cord-001835-0s7ok4uw	17	4	of	of	IN
cord-001835-0s7ok4uw	17	5	the	the	DT
cord-001835-0s7ok4uw	17	6	TIA-1	TIA-1	NNP
cord-001835-0s7ok4uw	17	7	/	/	SYM
cord-001835-0s7ok4uw	17	8	RNA	RNA	NNP
cord-001835-0s7ok4uw	17	9	interaction	interaction	NN
cord-001835-0s7ok4uw	17	10	provides	provide	VBZ
cord-001835-0s7ok4uw	17	11	a	a	DT
cord-001835-0s7ok4uw	17	12	new	new	JJ
cord-001835-0s7ok4uw	17	13	insight	insight	NN
cord-001835-0s7ok4uw	17	14	into	into	IN
cord-001835-0s7ok4uw	17	15	the	the	DT
cord-001835-0s7ok4uw	17	16	function	function	NN
cord-001835-0s7ok4uw	17	17	of	of	IN
cord-001835-0s7ok4uw	17	18	TIA-1	TIA-1	NNP
cord-001835-0s7ok4uw	17	19	in	in	IN
cord-001835-0s7ok4uw	17	20	recognizing	recognize	VBG
cord-001835-0s7ok4uw	17	21	new	new	JJ
cord-001835-0s7ok4uw	17	22	RNA	RNA	NNP
cord-001835-0s7ok4uw	17	23	targets	target	NNS
cord-001835-0s7ok4uw	17	24	[	[	-LRB-
cord-001835-0s7ok4uw	17	25	5	5	CD
cord-001835-0s7ok4uw	17	26	]	]	-RRB-
cord-001835-0s7ok4uw	17	27	,	,	,
cord-001835-0s7ok4uw	17	28	like	like	IN
cord-001835-0s7ok4uw	17	29	the	the	DT
cord-001835-0s7ok4uw	17	30	5	5	CD
cord-001835-0s7ok4uw	17	31	'	'	''
cord-001835-0s7ok4uw	17	32	Terminal	Terminal	NNP
cord-001835-0s7ok4uw	17	33	Oligopyrimidine	Oligopyrimidine	NNP
cord-001835-0s7ok4uw	17	34	Tracts	Tracts	NNP
cord-001835-0s7ok4uw	17	35	(	(	-LRB-
cord-001835-0s7ok4uw	17	36	5TOPs	5tops	CD
cord-001835-0s7ok4uw	17	37	)	)	-RRB-
cord-001835-0s7ok4uw	17	38	of	of	IN
cord-001835-0s7ok4uw	17	39	translationally	translationally	RB
cord-001835-0s7ok4uw	17	40	-	-	HYPH
cord-001835-0s7ok4uw	17	41	repressed	repress	VBN
cord-001835-0s7ok4uw	17	42	mRNAs	mRNAs	''
cord-001835-0s7ok4uw	17	43	.	.	.
cord-001835-0s7ok4uw	18	1	Along	along	IN
cord-001835-0s7ok4uw	18	2	with	with	IN
cord-001835-0s7ok4uw	18	3	TIA-1	TIA-1	NNP
cord-001835-0s7ok4uw	18	4	,	,	,
cord-001835-0s7ok4uw	18	5	the	the	DT
cord-001835-0s7ok4uw	18	6	RBP	RBP	NNP
cord-001835-0s7ok4uw	18	7	Hu	Hu	NNP
cord-001835-0s7ok4uw	18	8	antigen	antigen	NN
cord-001835-0s7ok4uw	18	9	R	r	NN
cord-001835-0s7ok4uw	18	10	(	(	-LRB-
cord-001835-0s7ok4uw	18	11	HuR	HuR	NNP
cord-001835-0s7ok4uw	18	12	)	)	-RRB-
cord-001835-0s7ok4uw	18	13	is	be	VBZ
cord-001835-0s7ok4uw	18	14	involved	involve	VBN
cord-001835-0s7ok4uw	18	15	in	in	IN
cord-001835-0s7ok4uw	18	16	the	the	DT
cord-001835-0s7ok4uw	18	17	assembly	assembly	NN
cord-001835-0s7ok4uw	18	18	/	/	SYM
cord-001835-0s7ok4uw	18	19	disassembly	disassembly	NN
cord-001835-0s7ok4uw	18	20	of	of	IN
cord-001835-0s7ok4uw	18	21	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	18	22	Stress	stress	NN
cord-001835-0s7ok4uw	18	23	Granules	Granules	NNP
cord-001835-0s7ok4uw	18	24	(	(	-LRB-
cord-001835-0s7ok4uw	18	25	SG	SG	NNP
cord-001835-0s7ok4uw	18	26	)	)	-RRB-
cord-001835-0s7ok4uw	18	27	,	,	,
cord-001835-0s7ok4uw	18	28	which	which	WDT
cord-001835-0s7ok4uw	18	29	arise	arise	VBP
cord-001835-0s7ok4uw	18	30	as	as	IN
cord-001835-0s7ok4uw	18	31	a	a	DT
cord-001835-0s7ok4uw	18	32	protective	protective	JJ
cord-001835-0s7ok4uw	18	33	mechanism	mechanism	NN
cord-001835-0s7ok4uw	18	34	by	by	IN
cord-001835-0s7ok4uw	18	35	preventing	prevent	VBG
cord-001835-0s7ok4uw	18	36	mRNA	mRNA	NNP
cord-001835-0s7ok4uw	18	37	decay	decay	NN
cord-001835-0s7ok4uw	18	38	under	under	IN
cord-001835-0s7ok4uw	18	39	stress	stress	NN
cord-001835-0s7ok4uw	18	40	situations	situation	NNS
cord-001835-0s7ok4uw	18	41	.	.	.
cord-001835-0s7ok4uw	19	1	Despite	despite	IN
cord-001835-0s7ok4uw	19	2	wide	wide	JJ
cord-001835-0s7ok4uw	19	3	acceptance	acceptance	NN
cord-001835-0s7ok4uw	19	4	that	that	WDT
cord-001835-0s7ok4uw	19	5	RBPs	RBPs	NNP
cord-001835-0s7ok4uw	19	6	harboring	harbor	VBG
cord-001835-0s7ok4uw	19	7	aggregation	aggregation	NN
cord-001835-0s7ok4uw	19	8	-	-	HYPH
cord-001835-0s7ok4uw	19	9	promoting	promote	VBG
cord-001835-0s7ok4uw	19	10	Prion	Prion	NNP
cord-001835-0s7ok4uw	19	11	Related	relate	VBN
cord-001835-0s7ok4uw	19	12	Domains	domain	NNS
cord-001835-0s7ok4uw	19	13	(	(	-LRB-
cord-001835-0s7ok4uw	19	14	PRDs	prd	NNS
cord-001835-0s7ok4uw	19	15	)	)	-RRB-
cord-001835-0s7ok4uw	19	16	,	,	,
cord-001835-0s7ok4uw	19	17	such	such	JJ
cord-001835-0s7ok4uw	19	18	as	as	IN
cord-001835-0s7ok4uw	19	19	TIA-1	TIA-1	NNP
cord-001835-0s7ok4uw	19	20	,	,	,
cord-001835-0s7ok4uw	19	21	stimulate	stimulate	VB
cord-001835-0s7ok4uw	19	22	rapid	rapid	JJ
cord-001835-0s7ok4uw	19	23	self	self	NN
cord-001835-0s7ok4uw	19	24	-	-	HYPH
cord-001835-0s7ok4uw	19	25	association	association	NN
cord-001835-0s7ok4uw	19	26	and	and	CC
cord-001835-0s7ok4uw	19	27	formation	formation	NN
cord-001835-0s7ok4uw	19	28	of	of	IN
cord-001835-0s7ok4uw	19	29	SGs	SGs	NNP
cord-001835-0s7ok4uw	19	30	,	,	,
cord-001835-0s7ok4uw	19	31	we	-PRON-	PRP
cord-001835-0s7ok4uw	19	32	propose	propose	VBP
cord-001835-0s7ok4uw	19	33	that	that	IN
cord-001835-0s7ok4uw	19	34	scaffolding	scaffold	VBG
cord-001835-0s7ok4uw	19	35	SGs	SGs	NNP
cord-001835-0s7ok4uw	19	36	may	may	MD
cord-001835-0s7ok4uw	19	37	be	be	VB
cord-001835-0s7ok4uw	19	38	driven	drive	VBN
cord-001835-0s7ok4uw	19	39	by	by	IN
cord-001835-0s7ok4uw	19	40	RBDs	RBDs	NNP
cord-001835-0s7ok4uw	19	41	,	,	,
cord-001835-0s7ok4uw	19	42	since	since	IN
cord-001835-0s7ok4uw	19	43	PRD	prd	NN
cord-001835-0s7ok4uw	19	44	-	-	HYPH
cord-001835-0s7ok4uw	19	45	lacking	lack	VBG
cord-001835-0s7ok4uw	19	46	RBPs	rbps	NN
cord-001835-0s7ok4uw	19	47	,	,	,
cord-001835-0s7ok4uw	19	48	like	like	IN
cord-001835-0s7ok4uw	19	49	HuR	hur	NN
cord-001835-0s7ok4uw	19	50	,	,	,
cord-001835-0s7ok4uw	19	51	often	often	RB
cord-001835-0s7ok4uw	19	52	form	form	VBP
cord-001835-0s7ok4uw	19	53	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	19	54	[	[	-LRB-
cord-001835-0s7ok4uw	19	55	6	6	CD
cord-001835-0s7ok4uw	19	56	,	,	,
cord-001835-0s7ok4uw	19	57	7	7	CD
cord-001835-0s7ok4uw	19	58	,	,	,
cord-001835-0s7ok4uw	19	59	8	8	CD
cord-001835-0s7ok4uw	19	60	]	]	-RRB-
cord-001835-0s7ok4uw	19	61	and	and	CC
cord-001835-0s7ok4uw	19	62	are	be	VBP
cord-001835-0s7ok4uw	19	63	included	include	VBN
cord-001835-0s7ok4uw	19	64	in	in	IN
cord-001835-0s7ok4uw	19	65	SGs	SGs	NNP
cord-001835-0s7ok4uw	19	66	.	.	.
cord-001835-0s7ok4uw	20	1	Under	under	IN
cord-001835-0s7ok4uw	20	2	continuous	continuous	JJ
cord-001835-0s7ok4uw	20	3	stress	stress	NN
cord-001835-0s7ok4uw	20	4	,	,	,
cord-001835-0s7ok4uw	20	5	the	the	DT
cord-001835-0s7ok4uw	20	6	transition	transition	NN
cord-001835-0s7ok4uw	20	7	from	from	IN
cord-001835-0s7ok4uw	20	8	the	the	DT
cord-001835-0s7ok4uw	20	9	physiological	physiological	JJ
cord-001835-0s7ok4uw	20	10	to	to	IN
cord-001835-0s7ok4uw	20	11	pathological	pathological	JJ
cord-001835-0s7ok4uw	20	12	aggregation	aggregation	NN
cord-001835-0s7ok4uw	20	13	of	of	IN
cord-001835-0s7ok4uw	20	14	RBPs	RBPs	NNP
cord-001835-0s7ok4uw	20	15	in	in	IN
cord-001835-0s7ok4uw	20	16	SGs	SGs	NNP
cord-001835-0s7ok4uw	20	17	may	may	MD
cord-001835-0s7ok4uw	20	18	depend	depend	VB
cord-001835-0s7ok4uw	20	19	on	on	IN
cord-001835-0s7ok4uw	20	20	post	post	JJ
cord-001835-0s7ok4uw	20	21	-	-	JJ
cord-001835-0s7ok4uw	20	22	translational	translational	JJ
cord-001835-0s7ok4uw	20	23	modifications	modification	NNS
cord-001835-0s7ok4uw	20	24	of	of	IN
cord-001835-0s7ok4uw	20	25	RBDs	rbds	NN
cord-001835-0s7ok4uw	20	26	.	.	.
cord-001835-0s7ok4uw	21	1	RNA	rna	NN
cord-001835-0s7ok4uw	21	2	-	-	HYPH
cord-001835-0s7ok4uw	21	3	binding	bind	VBG
cord-001835-0s7ok4uw	21	4	proteinopathies	proteinopathie	NNS
cord-001835-0s7ok4uw	21	5	,	,	,
cord-001835-0s7ok4uw	21	6	characterized	characterize	VBN
cord-001835-0s7ok4uw	21	7	by	by	IN
cord-001835-0s7ok4uw	21	8	the	the	DT
cord-001835-0s7ok4uw	21	9	nucleation	nucleation	NN
cord-001835-0s7ok4uw	21	10	of	of	IN
cord-001835-0s7ok4uw	21	11	irreversible	irreversible	JJ
cord-001835-0s7ok4uw	21	12	SGs	sg	NNS
cord-001835-0s7ok4uw	21	13	,	,	,
cord-001835-0s7ok4uw	21	14	are	be	VBP
cord-001835-0s7ok4uw	21	15	often	often	RB
cord-001835-0s7ok4uw	21	16	found	find	VBN
cord-001835-0s7ok4uw	21	17	in	in	IN
cord-001835-0s7ok4uw	21	18	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	21	19	diseases	disease	NNS
cord-001835-0s7ok4uw	21	20	.	.	.
cord-001835-0s7ok4uw	22	1	Altogether	altogether	RB
cord-001835-0s7ok4uw	22	2	,	,	,
cord-001835-0s7ok4uw	22	3	resulting	result	VBG
cord-001835-0s7ok4uw	22	4	insights	insight	NNS
cord-001835-0s7ok4uw	22	5	into	into	IN
cord-001835-0s7ok4uw	22	6	RNA	RNA	NNP
cord-001835-0s7ok4uw	22	7	biology	biology	NN
cord-001835-0s7ok4uw	22	8	suggest	suggest	VBP
cord-001835-0s7ok4uw	22	9	that	that	IN
cord-001835-0s7ok4uw	22	10	highly	highly	RB
cord-001835-0s7ok4uw	22	11	-	-	HYPH
cord-001835-0s7ok4uw	22	12	regulated	regulated	JJ
cord-001835-0s7ok4uw	22	13	RBPs	rbps	NN
cord-001835-0s7ok4uw	22	14	determine	determine	VBP
cord-001835-0s7ok4uw	22	15	mRNA	mRNA	NNP
cord-001835-0s7ok4uw	22	16	fate	fate	NN
cord-001835-0s7ok4uw	22	17	from	from	IN
cord-001835-0s7ok4uw	22	18	synthesis	synthesis	NN
cord-001835-0s7ok4uw	22	19	to	to	TO
cord-001835-0s7ok4uw	22	20	decay	decay	VB
cord-001835-0s7ok4uw	22	21	.	.	.
cord-001835-0s7ok4uw	23	1	A	a	DT
cord-001835-0s7ok4uw	23	2	threat	threat	NN
cord-001835-0s7ok4uw	23	3	to	to	IN
cord-001835-0s7ok4uw	23	4	70	70	CD
cord-001835-0s7ok4uw	23	5	million	million	CD
cord-001835-0s7ok4uw	23	6	people	people	NNS
cord-001835-0s7ok4uw	23	7	in	in	IN
cord-001835-0s7ok4uw	23	8	underdeveloped	underdeveloped	JJ
cord-001835-0s7ok4uw	23	9	nations	nation	NNS
cord-001835-0s7ok4uw	23	10	around	around	IN
cord-001835-0s7ok4uw	23	11	the	the	DT
cord-001835-0s7ok4uw	23	12	world	world	NN
cord-001835-0s7ok4uw	23	13	,	,	,
cord-001835-0s7ok4uw	23	14	African	african	JJ
cord-001835-0s7ok4uw	23	15	trypanosomiasis	trypanosomiasis	NN
cord-001835-0s7ok4uw	23	16	(	(	-LRB-
cord-001835-0s7ok4uw	23	17	sleeping	sleep	VBG
cord-001835-0s7ok4uw	23	18	sickness	sickness	NN
cord-001835-0s7ok4uw	23	19	)	)	-RRB-
cord-001835-0s7ok4uw	23	20	is	be	VBZ
cord-001835-0s7ok4uw	23	21	a	a	DT
cord-001835-0s7ok4uw	23	22	neglected	neglect	VBN
cord-001835-0s7ok4uw	23	23	tropical	tropical	JJ
cord-001835-0s7ok4uw	23	24	disease	disease	NN
cord-001835-0s7ok4uw	23	25	(	(	-LRB-
cord-001835-0s7ok4uw	23	26	NTD	NTD	NNP
cord-001835-0s7ok4uw	23	27	)	)	-RRB-
cord-001835-0s7ok4uw	23	28	caused	cause	VBN
cord-001835-0s7ok4uw	23	29	by	by	IN
cord-001835-0s7ok4uw	23	30	the	the	DT
cord-001835-0s7ok4uw	23	31	protozoan	protozoan	NN
cord-001835-0s7ok4uw	23	32	parasite	parasite	NN
cord-001835-0s7ok4uw	23	33	Trypanosoma	Trypanosoma	NNP
cord-001835-0s7ok4uw	23	34	brucei	brucei	NN
cord-001835-0s7ok4uw	23	35	(	(	-LRB-
cord-001835-0s7ok4uw	23	36	T.	T.	NNP
cord-001835-0s7ok4uw	23	37	brucei	brucei	NNP
cord-001835-0s7ok4uw	23	38	)	)	-RRB-
cord-001835-0s7ok4uw	23	39	.	.	.
cord-001835-0s7ok4uw	24	1	T.	T.	NNP
cord-001835-0s7ok4uw	24	2	brucei	brucei	NNP
cord-001835-0s7ok4uw	24	3	is	be	VBZ
cord-001835-0s7ok4uw	24	4	transmitted	transmit	VBN
cord-001835-0s7ok4uw	24	5	to	to	IN
cord-001835-0s7ok4uw	24	6	humans	human	NNS
cord-001835-0s7ok4uw	24	7	via	via	IN
cord-001835-0s7ok4uw	24	8	the	the	DT
cord-001835-0s7ok4uw	24	9	tsetse	tsetse	NN
cord-001835-0s7ok4uw	24	10	fly	fly	VB
cord-001835-0s7ok4uw	24	11	,	,	,
cord-001835-0s7ok4uw	24	12	and	and	CC
cord-001835-0s7ok4uw	24	13	replicates	replicate	VBZ
cord-001835-0s7ok4uw	24	14	in	in	IN
cord-001835-0s7ok4uw	24	15	the	the	DT
cord-001835-0s7ok4uw	24	16	blood	blood	NN
cord-001835-0s7ok4uw	24	17	before	before	IN
cord-001835-0s7ok4uw	24	18	crossing	cross	VBG
cord-001835-0s7ok4uw	24	19	into	into	IN
cord-001835-0s7ok4uw	24	20	the	the	DT
cord-001835-0s7ok4uw	24	21	brain	brain	NN
cord-001835-0s7ok4uw	24	22	,	,	,
cord-001835-0s7ok4uw	24	23	causing	cause	VBG
cord-001835-0s7ok4uw	24	24	death	death	NN
cord-001835-0s7ok4uw	24	25	for	for	IN
cord-001835-0s7ok4uw	24	26	the	the	DT
cord-001835-0s7ok4uw	24	27	infected	infected	JJ
cord-001835-0s7ok4uw	24	28	individual	individual	NN
cord-001835-0s7ok4uw	24	29	.	.	.
cord-001835-0s7ok4uw	25	1	Current	current	JJ
cord-001835-0s7ok4uw	25	2	treatments	treatment	NNS
cord-001835-0s7ok4uw	25	3	that	that	WDT
cord-001835-0s7ok4uw	25	4	are	be	VBP
cord-001835-0s7ok4uw	25	5	available	available	JJ
cord-001835-0s7ok4uw	25	6	for	for	IN
cord-001835-0s7ok4uw	25	7	African	african	JJ
cord-001835-0s7ok4uw	25	8	sleeping	sleeping	NN
cord-001835-0s7ok4uw	25	9	sickness	sickness	NN
cord-001835-0s7ok4uw	25	10	are	be	VBP
cord-001835-0s7ok4uw	25	11	highly	highly	RB
cord-001835-0s7ok4uw	25	12	toxic	toxic	JJ
cord-001835-0s7ok4uw	25	13	and	and	CC
cord-001835-0s7ok4uw	25	14	usually	usually	RB
cord-001835-0s7ok4uw	25	15	difficult	difficult	JJ
cord-001835-0s7ok4uw	25	16	to	to	TO
cord-001835-0s7ok4uw	25	17	administer	administer	VB
cord-001835-0s7ok4uw	25	18	past	past	IN
cord-001835-0s7ok4uw	25	19	the	the	DT
cord-001835-0s7ok4uw	25	20	blood	blood	NN
cord-001835-0s7ok4uw	25	21	-	-	HYPH
cord-001835-0s7ok4uw	25	22	brain	brain	NN
cord-001835-0s7ok4uw	25	23	barrier	barrier	NN
cord-001835-0s7ok4uw	25	24	.	.	.
cord-001835-0s7ok4uw	26	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	26	2	is	be	VBZ
cord-001835-0s7ok4uw	26	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	26	4	belief	belief	NN
cord-001835-0s7ok4uw	26	5	that	that	IN
cord-001835-0s7ok4uw	26	6	coupling	couple	VBG
cord-001835-0s7ok4uw	26	7	less	less	RBR
cord-001835-0s7ok4uw	26	8	toxic	toxic	JJ
cord-001835-0s7ok4uw	26	9	compounds	compound	NNS
cord-001835-0s7ok4uw	26	10	with	with	IN
cord-001835-0s7ok4uw	26	11	efficient	efficient	JJ
cord-001835-0s7ok4uw	26	12	drug	drug	NN
cord-001835-0s7ok4uw	26	13	delivery	delivery	NN
cord-001835-0s7ok4uw	26	14	systems	system	NNS
cord-001835-0s7ok4uw	26	15	will	will	MD
cord-001835-0s7ok4uw	26	16	contribute	contribute	VB
cord-001835-0s7ok4uw	26	17	to	to	IN
cord-001835-0s7ok4uw	26	18	the	the	DT
cord-001835-0s7ok4uw	26	19	development	development	NN
cord-001835-0s7ok4uw	26	20	of	of	IN
cord-001835-0s7ok4uw	26	21	the	the	DT
cord-001835-0s7ok4uw	26	22	most	most	RBS
cord-001835-0s7ok4uw	26	23	effective	effective	JJ
cord-001835-0s7ok4uw	26	24	drug	drug	NN
cord-001835-0s7ok4uw	26	25	against	against	IN
cord-001835-0s7ok4uw	26	26	African	african	JJ
cord-001835-0s7ok4uw	26	27	sleeping	sleep	VBG
cord-001835-0s7ok4uw	26	28	sickness	sickness	NN
cord-001835-0s7ok4uw	26	29	.	.	.
cord-001835-0s7ok4uw	27	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	27	2	goal	goal	NN
cord-001835-0s7ok4uw	27	3	was	be	VBD
cord-001835-0s7ok4uw	27	4	to	to	TO
cord-001835-0s7ok4uw	27	5	determine	determine	VB
cord-001835-0s7ok4uw	27	6	a	a	DT
cord-001835-0s7ok4uw	27	7	novel	novel	JJ
cord-001835-0s7ok4uw	27	8	and	and	CC
cord-001835-0s7ok4uw	27	9	effective	effective	JJ
cord-001835-0s7ok4uw	27	10	chemical	chemical	JJ
cord-001835-0s7ok4uw	27	11	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	27	12	with	with	IN
cord-001835-0s7ok4uw	27	13	the	the	DT
cord-001835-0s7ok4uw	27	14	potential	potential	NN
cord-001835-0s7ok4uw	27	15	to	to	TO
cord-001835-0s7ok4uw	27	16	prevent	prevent	VB
cord-001835-0s7ok4uw	27	17	the	the	DT
cord-001835-0s7ok4uw	27	18	replication	replication	NN
cord-001835-0s7ok4uw	27	19	of	of	IN
cord-001835-0s7ok4uw	27	20	T.	T.	NNP
cord-001835-0s7ok4uw	27	21	brucei	brucei	NN
cord-001835-0s7ok4uw	27	22	in	in	IN
cord-001835-0s7ok4uw	27	23	the	the	DT
cord-001835-0s7ok4uw	27	24	human	human	JJ
cord-001835-0s7ok4uw	27	25	body	body	NN
cord-001835-0s7ok4uw	27	26	.	.	.
cord-001835-0s7ok4uw	28	1	The	the	DT
cord-001835-0s7ok4uw	28	2	enzyme	enzyme	NN
cord-001835-0s7ok4uw	28	3	target	target	NN
cord-001835-0s7ok4uw	28	4	for	for	IN
cord-001835-0s7ok4uw	28	5	inhibition	inhibition	NN
cord-001835-0s7ok4uw	28	6	studied	study	VBN
cord-001835-0s7ok4uw	28	7	in	in	IN
cord-001835-0s7ok4uw	28	8	this	this	DT
cord-001835-0s7ok4uw	28	9	research	research	NN
cord-001835-0s7ok4uw	28	10	was	be	VBD
cord-001835-0s7ok4uw	28	11	6-phosphogluconate	6-phosphogluconate	CD
cord-001835-0s7ok4uw	28	12	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	28	13	(	(	-LRB-
cord-001835-0s7ok4uw	28	14	6PGDH	6pgdh	CD
cord-001835-0s7ok4uw	28	15	)	)	-RRB-
cord-001835-0s7ok4uw	28	16	,	,	,
cord-001835-0s7ok4uw	28	17	a	a	DT
cord-001835-0s7ok4uw	28	18	cytosolic	cytosolic	JJ
cord-001835-0s7ok4uw	28	19	enzyme	enzyme	NN
cord-001835-0s7ok4uw	28	20	in	in	IN
cord-001835-0s7ok4uw	28	21	the	the	DT
cord-001835-0s7ok4uw	28	22	pentose	pentose	NN
cord-001835-0s7ok4uw	28	23	phosphate	phosphate	NN
cord-001835-0s7ok4uw	28	24	pathway	pathway	NN
cord-001835-0s7ok4uw	28	25	(	(	-LRB-
cord-001835-0s7ok4uw	28	26	PPP	PPP	NNP
cord-001835-0s7ok4uw	28	27	)	)	-RRB-
cord-001835-0s7ok4uw	28	28	of	of	IN
cord-001835-0s7ok4uw	28	29	T.	T.	NNP
cord-001835-0s7ok4uw	28	30	brucei	brucei	NNP
cord-001835-0s7ok4uw	28	31	.	.	.
cord-001835-0s7ok4uw	29	1	6PGDH	6pgdh	CD
cord-001835-0s7ok4uw	29	2	is	be	VBZ
cord-001835-0s7ok4uw	29	3	essential	essential	JJ
cord-001835-0s7ok4uw	29	4	in	in	IN
cord-001835-0s7ok4uw	29	5	the	the	DT
cord-001835-0s7ok4uw	29	6	PPP	PPP	NNP
cord-001835-0s7ok4uw	29	7	due	due	IN
cord-001835-0s7ok4uw	29	8	to	to	IN
cord-001835-0s7ok4uw	29	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	29	10	ability	ability	NN
cord-001835-0s7ok4uw	29	11	to	to	TO
cord-001835-0s7ok4uw	29	12	oxidize	oxidize	VB
cord-001835-0s7ok4uw	29	13	6-phosphogluconate	6-phosphogluconate	CD
cord-001835-0s7ok4uw	29	14	into	into	IN
cord-001835-0s7ok4uw	29	15	ribulose-5-phosphate	ribulose-5-phosphate	NNP
cord-001835-0s7ok4uw	29	16	,	,	,
cord-001835-0s7ok4uw	29	17	which	which	WDT
cord-001835-0s7ok4uw	29	18	is	be	VBZ
cord-001835-0s7ok4uw	29	19	essential	essential	JJ
cord-001835-0s7ok4uw	29	20	for	for	IN
cord-001835-0s7ok4uw	29	21	the	the	DT
cord-001835-0s7ok4uw	29	22	formation	formation	NN
cord-001835-0s7ok4uw	29	23	of	of	IN
cord-001835-0s7ok4uw	29	24	nucleotides	nucleotide	NNS
cord-001835-0s7ok4uw	29	25	.	.	.
cord-001835-0s7ok4uw	30	1	Primer	primer	NN
cord-001835-0s7ok4uw	30	2	overlap	overlap	NN
cord-001835-0s7ok4uw	30	3	extension	extension	NN
cord-001835-0s7ok4uw	30	4	Polymerase	Polymerase	NNP
cord-001835-0s7ok4uw	30	5	Chain	Chain	NNP
cord-001835-0s7ok4uw	30	6	Reaction	reaction	NN
cord-001835-0s7ok4uw	30	7	(	(	-LRB-
cord-001835-0s7ok4uw	30	8	PCR	PCR	NNP
cord-001835-0s7ok4uw	30	9	)	)	-RRB-
cord-001835-0s7ok4uw	30	10	was	be	VBD
cord-001835-0s7ok4uw	30	11	used	use	VBN
cord-001835-0s7ok4uw	30	12	to	to	TO
cord-001835-0s7ok4uw	30	13	synthesize	synthesize	VB
cord-001835-0s7ok4uw	30	14	the	the	DT
cord-001835-0s7ok4uw	30	15	coding	code	VBG
cord-001835-0s7ok4uw	30	16	DNA	dna	NN
cord-001835-0s7ok4uw	30	17	sequence	sequence	NN
cord-001835-0s7ok4uw	30	18	of	of	IN
cord-001835-0s7ok4uw	30	19	the	the	DT
cord-001835-0s7ok4uw	30	20	6PGDH	6pgdh	CD
cord-001835-0s7ok4uw	30	21	gene	gene	NN
cord-001835-0s7ok4uw	30	22	,	,	,
cord-001835-0s7ok4uw	30	23	which	which	WDT
cord-001835-0s7ok4uw	30	24	was	be	VBD
cord-001835-0s7ok4uw	30	25	then	then	RB
cord-001835-0s7ok4uw	30	26	cloned	clone	VBN
cord-001835-0s7ok4uw	30	27	into	into	IN
cord-001835-0s7ok4uw	30	28	a	a	DT
cord-001835-0s7ok4uw	30	29	pNIC	pnic	JJ
cord-001835-0s7ok4uw	30	30	-	-	HYPH
cord-001835-0s7ok4uw	30	31	Bsa4	bsa4	JJ
cord-001835-0s7ok4uw	30	32	inducible	inducible	JJ
cord-001835-0s7ok4uw	30	33	expression	expression	NN
cord-001835-0s7ok4uw	30	34	plasmid	plasmid	NN
cord-001835-0s7ok4uw	30	35	with	with	IN
cord-001835-0s7ok4uw	30	36	an	an	DT
cord-001835-0s7ok4uw	30	37	N	n	CD
cord-001835-0s7ok4uw	30	38	-	-	HYPH
cord-001835-0s7ok4uw	30	39	terminal	terminal	NN
cord-001835-0s7ok4uw	30	40	6	6	CD
cord-001835-0s7ok4uw	30	41	Histidine	histidine	NN
cord-001835-0s7ok4uw	30	42	tag	tag	NN
cord-001835-0s7ok4uw	30	43	,	,	,
cord-001835-0s7ok4uw	30	44	by	by	IN
cord-001835-0s7ok4uw	30	45	way	way	NN
cord-001835-0s7ok4uw	30	46	of	of	IN
cord-001835-0s7ok4uw	30	47	ligation	ligation	NN
cord-001835-0s7ok4uw	30	48	independent	independent	JJ
cord-001835-0s7ok4uw	30	49	cloning	cloning	NN
cord-001835-0s7ok4uw	30	50	.	.	.
cord-001835-0s7ok4uw	31	1	The	the	DT
cord-001835-0s7ok4uw	31	2	protein	protein	NN
cord-001835-0s7ok4uw	31	3	was	be	VBD
cord-001835-0s7ok4uw	31	4	then	then	RB
cord-001835-0s7ok4uw	31	5	expressed	express	VBN
cord-001835-0s7ok4uw	31	6	in	in	IN
cord-001835-0s7ok4uw	31	7	BL21	BL21	NNP
cord-001835-0s7ok4uw	31	8	(	(	-LRB-
cord-001835-0s7ok4uw	31	9	DE3	DE3	NNP
cord-001835-0s7ok4uw	31	10	)	)	-RRB-
cord-001835-0s7ok4uw	31	11	Escherichia	escherichia	NN
cord-001835-0s7ok4uw	31	12	coli	coli	NNS
cord-001835-0s7ok4uw	31	13	(	(	-LRB-
cord-001835-0s7ok4uw	31	14	E.	E.	NNP
cord-001835-0s7ok4uw	31	15	coli	coli	NNS
cord-001835-0s7ok4uw	31	16	)	)	-RRB-
cord-001835-0s7ok4uw	31	17	cells	cell	NNS
cord-001835-0s7ok4uw	31	18	and	and	CC
cord-001835-0s7ok4uw	31	19	purified	purify	VBN
cord-001835-0s7ok4uw	31	20	via	via	IN
cord-001835-0s7ok4uw	31	21	nickel	nickel	NN
cord-001835-0s7ok4uw	31	22	column	column	NN
cord-001835-0s7ok4uw	31	23	affinity	affinity	NN
cord-001835-0s7ok4uw	31	24	and	and	CC
cord-001835-0s7ok4uw	31	25	size	size	NN
cord-001835-0s7ok4uw	31	26	exclusion	exclusion	NN
cord-001835-0s7ok4uw	31	27	fast	fast	IN
cord-001835-0s7ok4uw	31	28	protein	protein	NN
cord-001835-0s7ok4uw	31	29	liquid	liquid	NN
cord-001835-0s7ok4uw	31	30	chromatography	chromatography	NN
cord-001835-0s7ok4uw	31	31	(	(	-LRB-
cord-001835-0s7ok4uw	31	32	FPLC	FPLC	NNP
cord-001835-0s7ok4uw	31	33	)	)	-RRB-
cord-001835-0s7ok4uw	31	34	to	to	TO
cord-001835-0s7ok4uw	31	35	perform	perform	VB
cord-001835-0s7ok4uw	31	36	inhibition	inhibition	NN
cord-001835-0s7ok4uw	31	37	assays	assay	NNS
cord-001835-0s7ok4uw	31	38	.	.	.
cord-001835-0s7ok4uw	32	1	Through	through	IN
cord-001835-0s7ok4uw	32	2	virtual	virtual	JJ
cord-001835-0s7ok4uw	32	3	screening	screening	NN
cord-001835-0s7ok4uw	32	4	,	,	,
cord-001835-0s7ok4uw	32	5	various	various	JJ
cord-001835-0s7ok4uw	32	6	ligands	ligand	NNS
cord-001835-0s7ok4uw	32	7	obtained	obtain	VBN
cord-001835-0s7ok4uw	32	8	from	from	IN
cord-001835-0s7ok4uw	32	9	the	the	DT
cord-001835-0s7ok4uw	32	10	Chembridge	Chembridge	NNP
cord-001835-0s7ok4uw	32	11	Library	Library	NNP
cord-001835-0s7ok4uw	32	12	and	and	CC
cord-001835-0s7ok4uw	32	13	NIH	NIH	NNP
cord-001835-0s7ok4uw	32	14	Clinical	Clinical	NNP
cord-001835-0s7ok4uw	32	15	Collection	Collection	NNP
cord-001835-0s7ok4uw	32	16	)	)	-RRB-
cord-001835-0s7ok4uw	32	17	were	be	VBD
cord-001835-0s7ok4uw	32	18	docked	dock	VBN
cord-001835-0s7ok4uw	32	19	into	into	IN
cord-001835-0s7ok4uw	32	20	the	the	DT
cord-001835-0s7ok4uw	32	21	active	active	JJ
cord-001835-0s7ok4uw	32	22	site	site	NN
cord-001835-0s7ok4uw	32	23	of	of	IN
cord-001835-0s7ok4uw	32	24	the	the	DT
cord-001835-0s7ok4uw	32	25	crystal	crystal	JJ
cord-001835-0s7ok4uw	32	26	structure	structure	NN
cord-001835-0s7ok4uw	32	27	of	of	IN
cord-001835-0s7ok4uw	32	28	Tb6pgdh	Tb6pgdh	NNP
cord-001835-0s7ok4uw	33	1	(	(	-LRB-
cord-001835-0s7ok4uw	33	2	Pubchem	Pubchem	NNP
cord-001835-0s7ok4uw	33	3	identification	identification	NN
cord-001835-0s7ok4uw	33	4	1PGJ	1pgj	CD
cord-001835-0s7ok4uw	33	5	)	)	-RRB-
cord-001835-0s7ok4uw	34	1	using	use	VBG
cord-001835-0s7ok4uw	34	2	GOLD	gold	NN
cord-001835-0s7ok4uw	34	3	molecular	molecular	JJ
cord-001835-0s7ok4uw	34	4	docking	docking	NN
cord-001835-0s7ok4uw	34	5	software	software	NN
cord-001835-0s7ok4uw	34	6	.	.	.
cord-001835-0s7ok4uw	35	1	The	the	DT
cord-001835-0s7ok4uw	35	2	top	top	JJ
cord-001835-0s7ok4uw	35	3	scoring	scoring	NN
cord-001835-0s7ok4uw	35	4	compounds	compound	NNS
cord-001835-0s7ok4uw	35	5	were	be	VBD
cord-001835-0s7ok4uw	35	6	selected	select	VBN
cord-001835-0s7ok4uw	35	7	by	by	IN
cord-001835-0s7ok4uw	35	8	utilizing	utilize	VBG
cord-001835-0s7ok4uw	35	9	parameters	parameter	NNS
cord-001835-0s7ok4uw	35	10	such	such	JJ
cord-001835-0s7ok4uw	35	11	as	as	IN
cord-001835-0s7ok4uw	35	12	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	35	13	interactions	interaction	NNS
cord-001835-0s7ok4uw	35	14	,	,	,
cord-001835-0s7ok4uw	35	15	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	35	16	bonds	bond	NNS
cord-001835-0s7ok4uw	35	17	,	,	,
cord-001835-0s7ok4uw	35	18	and	and	CC
cord-001835-0s7ok4uw	35	19	Van	Van	NNP
cord-001835-0s7ok4uw	35	20	der	der	NNP
cord-001835-0s7ok4uw	35	21	Waals	Waals	NNP
cord-001835-0s7ok4uw	35	22	forces	force	NNS
cord-001835-0s7ok4uw	35	23	.	.	.
cord-001835-0s7ok4uw	36	1	The	the	DT
cord-001835-0s7ok4uw	36	2	compounds	compound	NNS
cord-001835-0s7ok4uw	36	3	with	with	IN
cord-001835-0s7ok4uw	36	4	the	the	DT
cord-001835-0s7ok4uw	36	5	best	good	JJS
cord-001835-0s7ok4uw	36	6	scores	score	NNS
cord-001835-0s7ok4uw	36	7	that	that	WDT
cord-001835-0s7ok4uw	36	8	also	also	RB
cord-001835-0s7ok4uw	36	9	satisfied	satisfy	VBD
cord-001835-0s7ok4uw	36	10	Lipinski	Lipinski	NNP
cord-001835-0s7ok4uw	36	11	's	's	POS
cord-001835-0s7ok4uw	36	12	Rule	Rule	NNP
cord-001835-0s7ok4uw	36	13	of	of	IN
cord-001835-0s7ok4uw	36	14	5	5	CD
cord-001835-0s7ok4uw	36	15	criteria	criterion	NNS
cord-001835-0s7ok4uw	36	16	for	for	IN
cord-001835-0s7ok4uw	36	17	druggability	druggability	NN
cord-001835-0s7ok4uw	36	18	were	be	VBD
cord-001835-0s7ok4uw	36	19	then	then	RB
cord-001835-0s7ok4uw	36	20	tested	test	VBN
cord-001835-0s7ok4uw	36	21	in	in	IN
cord-001835-0s7ok4uw	36	22	spectrophotometric	spectrophotometric	JJ
cord-001835-0s7ok4uw	36	23	enzyme	enzyme	NN
cord-001835-0s7ok4uw	36	24	inhibition	inhibition	NN
cord-001835-0s7ok4uw	36	25	assays	assay	NNS
cord-001835-0s7ok4uw	36	26	monitoring	monitor	VBG
cord-001835-0s7ok4uw	36	27	the	the	DT
cord-001835-0s7ok4uw	36	28	absorbance	absorbance	NN
cord-001835-0s7ok4uw	36	29	of	of	IN
cord-001835-0s7ok4uw	36	30	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	36	31	at	at	IN
cord-001835-0s7ok4uw	36	32	340	340	CD
cord-001835-0s7ok4uw	36	33	nm	nm	NN
cord-001835-0s7ok4uw	36	34	.	.	.
cord-001835-0s7ok4uw	37	1	Compounds	compound	NNS
cord-001835-0s7ok4uw	37	2	that	that	WDT
cord-001835-0s7ok4uw	37	3	show	show	VBP
cord-001835-0s7ok4uw	37	4	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	37	5	activity	activity	NN
cord-001835-0s7ok4uw	37	6	in	in	IN
cord-001835-0s7ok4uw	37	7	the	the	DT
cord-001835-0s7ok4uw	37	8	assays	assay	NNS
cord-001835-0s7ok4uw	37	9	will	will	MD
cord-001835-0s7ok4uw	37	10	be	be	VB
cord-001835-0s7ok4uw	37	11	taken	take	VBN
cord-001835-0s7ok4uw	37	12	to	to	IN
cord-001835-0s7ok4uw	37	13	higher	high	JJR
cord-001835-0s7ok4uw	37	14	levels	level	NNS
cord-001835-0s7ok4uw	37	15	of	of	IN
cord-001835-0s7ok4uw	37	16	testing	testing	NN
cord-001835-0s7ok4uw	37	17	to	to	TO
cord-001835-0s7ok4uw	37	18	determine	determine	VB
cord-001835-0s7ok4uw	37	19	their	-PRON-	PRP$
cord-001835-0s7ok4uw	37	20	effect	effect	NN
cord-001835-0s7ok4uw	37	21	on	on	IN
cord-001835-0s7ok4uw	37	22	T.	T.	NNP
cord-001835-0s7ok4uw	37	23	brucei	brucei	NN
cord-001835-0s7ok4uw	37	24	in	in	IN
cord-001835-0s7ok4uw	37	25	other	other	JJ
cord-001835-0s7ok4uw	37	26	organisms	organism	NNS
cord-001835-0s7ok4uw	37	27	.	.	.
cord-001835-0s7ok4uw	38	1	NMR	NMR	NNP
cord-001835-0s7ok4uw	38	2	studies	study	NNS
cord-001835-0s7ok4uw	38	3	of	of	IN
cord-001835-0s7ok4uw	38	4	the	the	DT
cord-001835-0s7ok4uw	38	5	structural	structural	JJ
cord-001835-0s7ok4uw	38	6	influence	influence	NN
cord-001835-0s7ok4uw	38	7	of	of	IN
cord-001835-0s7ok4uw	38	8	phosphopantetheinylation	phosphopantetheinylation	NN
cord-001835-0s7ok4uw	38	9	in	in	IN
cord-001835-0s7ok4uw	38	10	nonribosomal	nonribosomal	NNP
cord-001835-0s7ok4uw	38	11	peptide	peptide	JJ
cord-001835-0s7ok4uw	38	12	synthetase	synthetase	NN
cord-001835-0s7ok4uw	38	13	carrier	carrier	NN
cord-001835-0s7ok4uw	38	14	proteins	protein	NNS
cord-001835-0s7ok4uw	38	15	and	and	CC
cord-001835-0s7ok4uw	38	16	impact	impact	NN
cord-001835-0s7ok4uw	38	17	on	on	IN
cord-001835-0s7ok4uw	38	18	binding	bind	VBG
cord-001835-0s7ok4uw	38	19	affinities	affinity	NNS
cord-001835-0s7ok4uw	38	20	Andrew	Andrew	NNP
cord-001835-0s7ok4uw	38	21	Goodrich	Goodrich	NNP
cord-001835-0s7ok4uw	38	22	1	1	CD
cord-001835-0s7ok4uw	38	23	,	,	,
cord-001835-0s7ok4uw	38	24	Dominique	Dominique	NNP
cord-001835-0s7ok4uw	38	25	Frueh	Frueh	NNP
cord-001835-0s7ok4uw	38	26	1	1	CD
cord-001835-0s7ok4uw	38	27	1	1	CD
cord-001835-0s7ok4uw	38	28	Nonribosomal	Nonribosomal	NNP
cord-001835-0s7ok4uw	38	29	peptide	peptide	NN
cord-001835-0s7ok4uw	38	30	synthetases	synthetase	NNS
cord-001835-0s7ok4uw	38	31	(	(	-LRB-
cord-001835-0s7ok4uw	38	32	NRPSs	NRPSs	NNP
cord-001835-0s7ok4uw	38	33	)	)	-RRB-
cord-001835-0s7ok4uw	38	34	are	be	VBP
cord-001835-0s7ok4uw	38	35	modular	modular	JJ
cord-001835-0s7ok4uw	38	36	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	38	37	systems	system	NNS
cord-001835-0s7ok4uw	38	38	responsible	responsible	JJ
cord-001835-0s7ok4uw	38	39	for	for	IN
cord-001835-0s7ok4uw	38	40	the	the	DT
cord-001835-0s7ok4uw	38	41	production	production	NN
cord-001835-0s7ok4uw	38	42	of	of	IN
cord-001835-0s7ok4uw	38	43	complex	complex	JJ
cord-001835-0s7ok4uw	38	44	secondary	secondary	JJ
cord-001835-0s7ok4uw	38	45	metabolites	metabolite	NNS
cord-001835-0s7ok4uw	38	46	in	in	IN
cord-001835-0s7ok4uw	38	47	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	38	48	and	and	CC
cord-001835-0s7ok4uw	38	49	fungi	fungus	NNS
cord-001835-0s7ok4uw	38	50	.	.	.
cord-001835-0s7ok4uw	39	1	Each	each	DT
cord-001835-0s7ok4uw	39	2	module	module	NN
cord-001835-0s7ok4uw	39	3	is	be	VBZ
cord-001835-0s7ok4uw	39	4	comprised	comprise	VBN
cord-001835-0s7ok4uw	39	5	of	of	IN
cord-001835-0s7ok4uw	39	6	(	(	-LRB-
cord-001835-0s7ok4uw	39	7	at	at	IN
cord-001835-0s7ok4uw	39	8	least	least	JJS
cord-001835-0s7ok4uw	39	9	)	)	-RRB-
cord-001835-0s7ok4uw	39	10	three	three	CD
cord-001835-0s7ok4uw	39	11	core	core	NN
cord-001835-0s7ok4uw	39	12	domains	domain	NNS
cord-001835-0s7ok4uw	39	13	whose	whose	WP$
cord-001835-0s7ok4uw	39	14	combined	combine	VBN
cord-001835-0s7ok4uw	39	15	action	action	NN
cord-001835-0s7ok4uw	39	16	leads	lead	VBZ
cord-001835-0s7ok4uw	39	17	to	to	IN
cord-001835-0s7ok4uw	39	18	the	the	DT
cord-001835-0s7ok4uw	39	19	selection	selection	NN
cord-001835-0s7ok4uw	39	20	,	,	,
cord-001835-0s7ok4uw	39	21	activation	activation	NN
cord-001835-0s7ok4uw	39	22	,	,	,
cord-001835-0s7ok4uw	39	23	and	and	CC
cord-001835-0s7ok4uw	39	24	incorporation	incorporation	NN
cord-001835-0s7ok4uw	39	25	of	of	IN
cord-001835-0s7ok4uw	39	26	a	a	DT
cord-001835-0s7ok4uw	39	27	single	single	JJ
cord-001835-0s7ok4uw	39	28	small	small	JJ
cord-001835-0s7ok4uw	39	29	molecule	molecule	NN
cord-001835-0s7ok4uw	39	30	into	into	IN
cord-001835-0s7ok4uw	39	31	a	a	DT
cord-001835-0s7ok4uw	39	32	growing	grow	VBG
cord-001835-0s7ok4uw	39	33	peptide	peptide	NN
cord-001835-0s7ok4uw	39	34	.	.	.
cord-001835-0s7ok4uw	40	1	Central	central	JJ
cord-001835-0s7ok4uw	40	2	to	to	IN
cord-001835-0s7ok4uw	40	3	each	each	DT
cord-001835-0s7ok4uw	40	4	module	module	NN
cord-001835-0s7ok4uw	40	5	is	be	VBZ
cord-001835-0s7ok4uw	40	6	the	the	DT
cord-001835-0s7ok4uw	40	7	carrier	carrier	NN
cord-001835-0s7ok4uw	40	8	protein	protein	NN
cord-001835-0s7ok4uw	40	9	(	(	-LRB-
cord-001835-0s7ok4uw	40	10	CP	CP	NNP
cord-001835-0s7ok4uw	40	11	)	)	-RRB-
cord-001835-0s7ok4uw	40	12	,	,	,
cord-001835-0s7ok4uw	40	13	which	which	WDT
cord-001835-0s7ok4uw	40	14	is	be	VBZ
cord-001835-0s7ok4uw	40	15	first	first	RB
cord-001835-0s7ok4uw	40	16	primed	prime	VBN
cord-001835-0s7ok4uw	40	17	via	via	IN
cord-001835-0s7ok4uw	40	18	attachment	attachment	NN
cord-001835-0s7ok4uw	40	19	of	of	IN
cord-001835-0s7ok4uw	40	20	a	a	DT
cord-001835-0s7ok4uw	40	21	4'-phosphopantetheine	4'-phosphopantetheine	CD
cord-001835-0s7ok4uw	40	22	moiety	moiety	NN
cord-001835-0s7ok4uw	40	23	(	(	-LRB-
cord-001835-0s7ok4uw	40	24	ppant	ppant	NNP
cord-001835-0s7ok4uw	40	25	arm	arm	NN
cord-001835-0s7ok4uw	40	26	)	)	-RRB-
cord-001835-0s7ok4uw	40	27	to	to	IN
cord-001835-0s7ok4uw	40	28	a	a	DT
cord-001835-0s7ok4uw	40	29	conserved	conserved	JJ
cord-001835-0s7ok4uw	40	30	serine	serine	NN
cord-001835-0s7ok4uw	40	31	to	to	TO
cord-001835-0s7ok4uw	40	32	generate	generate	VB
cord-001835-0s7ok4uw	40	33	the	the	DT
cord-001835-0s7ok4uw	40	34	active	active	JJ
cord-001835-0s7ok4uw	40	35	holo	holo	NN
cord-001835-0s7ok4uw	40	36	form	form	NN
cord-001835-0s7ok4uw	40	37	.	.	.
cord-001835-0s7ok4uw	41	1	An	an	DT
cord-001835-0s7ok4uw	41	2	adenylation	adenylation	NN
cord-001835-0s7ok4uw	41	3	(	(	-LRB-
cord-001835-0s7ok4uw	41	4	A	a	NN
cord-001835-0s7ok4uw	41	5	)	)	-RRB-
cord-001835-0s7ok4uw	41	6	domain	domain	NN
cord-001835-0s7ok4uw	41	7	then	then	RB
cord-001835-0s7ok4uw	41	8	covalently	covalently	RB
cord-001835-0s7ok4uw	41	9	attaches	attach	VBZ
cord-001835-0s7ok4uw	41	10	an	an	DT
cord-001835-0s7ok4uw	41	11	amino	amino	NN
cord-001835-0s7ok4uw	41	12	or	or	CC
cord-001835-0s7ok4uw	41	13	aryl	aryl	NN
cord-001835-0s7ok4uw	41	14	ABSTRACT	abstract	JJ
cord-001835-0s7ok4uw	41	15	acid	acid	NN
cord-001835-0s7ok4uw	41	16	onto	onto	IN
cord-001835-0s7ok4uw	41	17	the	the	DT
cord-001835-0s7ok4uw	41	18	ppant	ppant	JJ
cord-001835-0s7ok4uw	41	19	arm	arm	NN
cord-001835-0s7ok4uw	41	20	via	via	IN
cord-001835-0s7ok4uw	41	21	formation	formation	NN
cord-001835-0s7ok4uw	41	22	of	of	IN
cord-001835-0s7ok4uw	41	23	a	a	DT
cord-001835-0s7ok4uw	41	24	thioester	thioester	NN
cord-001835-0s7ok4uw	41	25	.	.	.
cord-001835-0s7ok4uw	42	1	The	the	DT
cord-001835-0s7ok4uw	42	2	CP	CP	NNP
cord-001835-0s7ok4uw	42	3	then	then	RB
cord-001835-0s7ok4uw	42	4	shuttles	shuttle	NNS
cord-001835-0s7ok4uw	42	5	activated	activate	VBD
cord-001835-0s7ok4uw	42	6	monomers	monomer	NNS
cord-001835-0s7ok4uw	42	7	and	and	CC
cord-001835-0s7ok4uw	42	8	growing	grow	VBG
cord-001835-0s7ok4uw	42	9	peptides	peptide	NNS
cord-001835-0s7ok4uw	42	10	between	between	IN
cord-001835-0s7ok4uw	42	11	the	the	DT
cord-001835-0s7ok4uw	42	12	active	active	JJ
cord-001835-0s7ok4uw	42	13	sites	site	NNS
cord-001835-0s7ok4uw	42	14	of	of	IN
cord-001835-0s7ok4uw	42	15	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	42	16	domains	domain	NNS
cord-001835-0s7ok4uw	42	17	in	in	IN
cord-001835-0s7ok4uw	42	18	both	both	CC
cord-001835-0s7ok4uw	42	19	the	the	DT
cord-001835-0s7ok4uw	42	20	same	same	JJ
cord-001835-0s7ok4uw	42	21	and	and	CC
cord-001835-0s7ok4uw	42	22	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	42	23	modules	module	NNS
cord-001835-0s7ok4uw	42	24	.	.	.
cord-001835-0s7ok4uw	43	1	During	during	IN
cord-001835-0s7ok4uw	43	2	CP	cp	NN
cord-001835-0s7ok4uw	43	3	priming	priming	NN
cord-001835-0s7ok4uw	43	4	and	and	CC
cord-001835-0s7ok4uw	43	5	peptide	peptide	NN
cord-001835-0s7ok4uw	43	6	elongation	elongation	NN
cord-001835-0s7ok4uw	43	7	,	,	,
cord-001835-0s7ok4uw	43	8	a	a	DT
cord-001835-0s7ok4uw	43	9	CP	cp	NN
cord-001835-0s7ok4uw	43	10	thus	thus	RB
cord-001835-0s7ok4uw	43	11	exists	exist	VBZ
cord-001835-0s7ok4uw	43	12	in	in	IN
cord-001835-0s7ok4uw	43	13	multiple	multiple	JJ
cord-001835-0s7ok4uw	43	14	different	different	JJ
cord-001835-0s7ok4uw	43	15	post	post	JJ
cord-001835-0s7ok4uw	43	16	-	-	JJ
cord-001835-0s7ok4uw	43	17	translational	translational	JJ
cord-001835-0s7ok4uw	43	18	states	state	NNS
cord-001835-0s7ok4uw	43	19	and	and	CC
cord-001835-0s7ok4uw	43	20	interacts	interact	VBZ
cord-001835-0s7ok4uw	43	21	with	with	IN
cord-001835-0s7ok4uw	43	22	numerous	numerous	JJ
cord-001835-0s7ok4uw	43	23	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	43	24	domains	domain	NNS
cord-001835-0s7ok4uw	43	25	.	.	.
cord-001835-0s7ok4uw	44	1	Understanding	understand	VBG
cord-001835-0s7ok4uw	44	2	how	how	WRB
cord-001835-0s7ok4uw	44	3	NRPSs	nrps	NNS
cord-001835-0s7ok4uw	44	4	are	be	VBP
cord-001835-0s7ok4uw	44	5	able	able	JJ
cord-001835-0s7ok4uw	44	6	to	to	TO
cord-001835-0s7ok4uw	44	7	efficiently	efficiently	RB
cord-001835-0s7ok4uw	44	8	orchestrate	orchestrate	VB
cord-001835-0s7ok4uw	44	9	this	this	DT
cord-001835-0s7ok4uw	44	10	series	series	NN
cord-001835-0s7ok4uw	44	11	of	of	IN
cord-001835-0s7ok4uw	44	12	sequential	sequential	JJ
cord-001835-0s7ok4uw	44	13	protein	protein	NN
cord-001835-0s7ok4uw	44	14	-	-	HYPH
cord-001835-0s7ok4uw	44	15	protein	protein	NN
cord-001835-0s7ok4uw	44	16	interactions	interaction	NNS
cord-001835-0s7ok4uw	44	17	between	between	IN
cord-001835-0s7ok4uw	44	18	a	a	DT
cord-001835-0s7ok4uw	44	19	CP	cp	NN
cord-001835-0s7ok4uw	44	20	and	and	CC
cord-001835-0s7ok4uw	44	21	its	-PRON-	PRP$
cord-001835-0s7ok4uw	44	22	partner	partner	NN
cord-001835-0s7ok4uw	44	23	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	44	24	domains	domain	NNS
cord-001835-0s7ok4uw	44	25	is	be	VBZ
cord-001835-0s7ok4uw	44	26	key	key	JJ
cord-001835-0s7ok4uw	44	27	to	to	IN
cord-001835-0s7ok4uw	44	28	unraveling	unravel	VBG
cord-001835-0s7ok4uw	44	29	the	the	DT
cord-001835-0s7ok4uw	44	30	molecular	molecular	JJ
cord-001835-0s7ok4uw	44	31	mechanism	mechanism	NN
cord-001835-0s7ok4uw	44	32	of	of	IN
cord-001835-0s7ok4uw	44	33	NRP	NRP	NNP
cord-001835-0s7ok4uw	44	34	synthesis	synthesis	NN
cord-001835-0s7ok4uw	44	35	.	.	.
cord-001835-0s7ok4uw	45	1	Using	use	VBG
cord-001835-0s7ok4uw	45	2	a	a	DT
cord-001835-0s7ok4uw	45	3	combination	combination	NN
cord-001835-0s7ok4uw	45	4	of	of	IN
cord-001835-0s7ok4uw	45	5	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	45	6	titration	titration	NN
cord-001835-0s7ok4uw	45	7	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	45	8	and	and	CC
cord-001835-0s7ok4uw	45	9	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	45	10	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	45	11	resonance	resonance	NN
cord-001835-0s7ok4uw	45	12	(	(	-LRB-
cord-001835-0s7ok4uw	45	13	NMR	NMR	NNP
cord-001835-0s7ok4uw	45	14	)	)	-RRB-
cord-001835-0s7ok4uw	45	15	titrations	titration	NNS
cord-001835-0s7ok4uw	45	16	,	,	,
cord-001835-0s7ok4uw	45	17	we	-PRON-	PRP
cord-001835-0s7ok4uw	45	18	found	find	VBD
cord-001835-0s7ok4uw	45	19	that	that	IN
cord-001835-0s7ok4uw	45	20	converting	convert	VBG
cord-001835-0s7ok4uw	45	21	a	a	DT
cord-001835-0s7ok4uw	45	22	CP	cp	NN
cord-001835-0s7ok4uw	45	23	from	from	IN
cord-001835-0s7ok4uw	45	24	the	the	DT
cord-001835-0s7ok4uw	45	25	apo	apo	NNP
cord-001835-0s7ok4uw	45	26	to	to	TO
cord-001835-0s7ok4uw	45	27	holo	holo	NNP
cord-001835-0s7ok4uw	45	28	form	form	NN
cord-001835-0s7ok4uw	45	29	alters	alter	VBZ
cord-001835-0s7ok4uw	45	30	its	-PRON-	PRP$
cord-001835-0s7ok4uw	45	31	affinity	affinity	NN
cord-001835-0s7ok4uw	45	32	for	for	IN
cord-001835-0s7ok4uw	45	33	its	-PRON-	PRP$
cord-001835-0s7ok4uw	45	34	partner	partner	NN
cord-001835-0s7ok4uw	45	35	A	a	DT
cord-001835-0s7ok4uw	45	36	domain	domain	NN
cord-001835-0s7ok4uw	45	37	.	.	.
cord-001835-0s7ok4uw	46	1	This	this	DT
cord-001835-0s7ok4uw	46	2	change	change	NN
cord-001835-0s7ok4uw	46	3	in	in	IN
cord-001835-0s7ok4uw	46	4	binding	binding	NN
cord-001835-0s7ok4uw	46	5	suggests	suggest	VBZ
cord-001835-0s7ok4uw	46	6	a	a	DT
cord-001835-0s7ok4uw	46	7	means	means	NN
cord-001835-0s7ok4uw	46	8	by	by	IN
cord-001835-0s7ok4uw	46	9	which	which	WDT
cord-001835-0s7ok4uw	46	10	directionality	directionality	NN
cord-001835-0s7ok4uw	46	11	in	in	IN
cord-001835-0s7ok4uw	46	12	protein	protein	NN
cord-001835-0s7ok4uw	46	13	-	-	HYPH
cord-001835-0s7ok4uw	46	14	protein	protein	NN
cord-001835-0s7ok4uw	46	15	interactions	interaction	NNS
cord-001835-0s7ok4uw	46	16	is	be	VBZ
cord-001835-0s7ok4uw	46	17	achieved	achieve	VBN
cord-001835-0s7ok4uw	46	18	in	in	IN
cord-001835-0s7ok4uw	46	19	NRPSs	NRPSs	NNP
cord-001835-0s7ok4uw	46	20	.	.	.
cord-001835-0s7ok4uw	47	1	However	however	RB
cord-001835-0s7ok4uw	47	2	,	,	,
cord-001835-0s7ok4uw	47	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	47	4	also	also	RB
cord-001835-0s7ok4uw	47	5	found	find	VBD
cord-001835-0s7ok4uw	47	6	that	that	IN
cord-001835-0s7ok4uw	47	7	A	a	DT
cord-001835-0s7ok4uw	47	8	domain	domain	NN
cord-001835-0s7ok4uw	47	9	binding	binding	NN
cord-001835-0s7ok4uw	47	10	affects	affect	VBZ
cord-001835-0s7ok4uw	47	11	the	the	DT
cord-001835-0s7ok4uw	47	12	same	same	JJ
cord-001835-0s7ok4uw	47	13	subset	subset	NN
cord-001835-0s7ok4uw	47	14	of	of	IN
cord-001835-0s7ok4uw	47	15	residues	residue	NNS
cord-001835-0s7ok4uw	47	16	in	in	IN
cord-001835-0s7ok4uw	47	17	both	both	CC
cord-001835-0s7ok4uw	47	18	the	the	DT
cord-001835-0s7ok4uw	47	19	apo	apo	NNP
cord-001835-0s7ok4uw	47	20	and	and	CC
cord-001835-0s7ok4uw	47	21	holo	holo	NNP
cord-001835-0s7ok4uw	47	22	forms	form	NNS
cord-001835-0s7ok4uw	47	23	.	.	.
cord-001835-0s7ok4uw	48	1	In	in	IN
cord-001835-0s7ok4uw	48	2	order	order	NN
cord-001835-0s7ok4uw	48	3	to	to	TO
cord-001835-0s7ok4uw	48	4	identify	identify	VB
cord-001835-0s7ok4uw	48	5	the	the	DT
cord-001835-0s7ok4uw	48	6	molecular	molecular	JJ
cord-001835-0s7ok4uw	48	7	features	feature	NNS
cord-001835-0s7ok4uw	48	8	underpinning	underpin	VBG
cord-001835-0s7ok4uw	48	9	this	this	DT
cord-001835-0s7ok4uw	48	10	difference	difference	NN
cord-001835-0s7ok4uw	48	11	in	in	IN
cord-001835-0s7ok4uw	48	12	affinity	affinity	NN
cord-001835-0s7ok4uw	48	13	,	,	,
cord-001835-0s7ok4uw	48	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	48	15	solved	solve	VBD
cord-001835-0s7ok4uw	48	16	the	the	DT
cord-001835-0s7ok4uw	48	17	NMR	NMR	NNP
cord-001835-0s7ok4uw	48	18	solution	solution	NN
cord-001835-0s7ok4uw	48	19	structures	structure	NNS
cord-001835-0s7ok4uw	48	20	of	of	IN
cord-001835-0s7ok4uw	48	21	the	the	DT
cord-001835-0s7ok4uw	48	22	apo	apo	NNP
cord-001835-0s7ok4uw	48	23	and	and	CC
cord-001835-0s7ok4uw	48	24	holo	holo	NNP
cord-001835-0s7ok4uw	48	25	forms	form	NNS
cord-001835-0s7ok4uw	48	26	of	of	IN
cord-001835-0s7ok4uw	48	27	the	the	DT
cord-001835-0s7ok4uw	48	28	CP	cp	NN
cord-001835-0s7ok4uw	48	29	.	.	.
cord-001835-0s7ok4uw	49	1	Here	here	RB
cord-001835-0s7ok4uw	49	2	,	,	,
cord-001835-0s7ok4uw	49	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	49	4	present	present	VBP
cord-001835-0s7ok4uw	49	5	the	the	DT
cord-001835-0s7ok4uw	49	6	solution	solution	NN
cord-001835-0s7ok4uw	49	7	structures	structure	NNS
cord-001835-0s7ok4uw	49	8	of	of	IN
cord-001835-0s7ok4uw	49	9	an	an	DT
cord-001835-0s7ok4uw	49	10	apo	apo	NNP
cord-001835-0s7ok4uw	49	11	and	and	CC
cord-001835-0s7ok4uw	49	12	holo	holo	NNP
cord-001835-0s7ok4uw	49	13	CP	CP	NNP
cord-001835-0s7ok4uw	49	14	and	and	CC
cord-001835-0s7ok4uw	49	15	discuss	discuss	VB
cord-001835-0s7ok4uw	49	16	them	-PRON-	PRP
cord-001835-0s7ok4uw	49	17	in	in	IN
cord-001835-0s7ok4uw	49	18	light	light	NN
cord-001835-0s7ok4uw	49	19	of	of	IN
cord-001835-0s7ok4uw	49	20	their	-PRON-	PRP$
cord-001835-0s7ok4uw	49	21	differential	differential	JJ
cord-001835-0s7ok4uw	49	22	binding	binding	NN
cord-001835-0s7ok4uw	49	23	to	to	IN
cord-001835-0s7ok4uw	49	24	an	an	DT
cord-001835-0s7ok4uw	49	25	A	A	NNP
cord-001835-0s7ok4uw	49	26	domain	domain	NN
cord-001835-0s7ok4uw	49	27	.	.	.
cord-001835-0s7ok4uw	50	1	Functional	functional	JJ
cord-001835-0s7ok4uw	50	2	analysis	analysis	NN
cord-001835-0s7ok4uw	50	3	of	of	IN
cord-001835-0s7ok4uw	50	4	of	of	IN
cord-001835-0s7ok4uw	50	5	conditional	conditional	JJ
cord-001835-0s7ok4uw	50	6	analog	analog	NN
cord-001835-0s7ok4uw	50	7	-	-	HYPH
cord-001835-0s7ok4uw	50	8	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	50	9	alleles	allele	NNS
cord-001835-0s7ok4uw	50	10	of	of	IN
cord-001835-0s7ok4uw	50	11	essential	essential	JJ
cord-001835-0s7ok4uw	50	12	protein	protein	NN
cord-001835-0s7ok4uw	50	13	kinases	kinase	NNS
cord-001835-0s7ok4uw	50	14	in	in	IN
cord-001835-0s7ok4uw	50	15	the	the	DT
cord-001835-0s7ok4uw	50	16	fission	fission	NN
cord-001835-0s7ok4uw	50	17	yeast	yeast	NN
cord-001835-0s7ok4uw	50	18	Schizosaccharomyces	Schizosaccharomyces	NNP
cord-001835-0s7ok4uw	50	19	pombe	pombe	NN
cord-001835-0s7ok4uw	50	20	.	.	.
cord-001835-0s7ok4uw	51	1	Juraj	Juraj	NNP
cord-001835-0s7ok4uw	51	2	Gregan	Gregan	NNP
cord-001835-0s7ok4uw	51	3	1	1	CD
cord-001835-0s7ok4uw	51	4	,	,	,
cord-001835-0s7ok4uw	51	5	2	2	CD
cord-001835-0s7ok4uw	51	6	1	1	CD
cord-001835-0s7ok4uw	51	7	Mfpl	Mfpl	NNP
cord-001835-0s7ok4uw	51	8	/	/	SYM
cord-001835-0s7ok4uw	51	9	imp	imp	NNP
cord-001835-0s7ok4uw	51	10	,	,	,
cord-001835-0s7ok4uw	51	11	2	2	CD
cord-001835-0s7ok4uw	51	12	 	 	_SP
cord-001835-0s7ok4uw	52	1	The	the	DT
cord-001835-0s7ok4uw	52	2	genome	genome	NN
cord-001835-0s7ok4uw	52	3	of	of	IN
cord-001835-0s7ok4uw	52	4	the	the	DT
cord-001835-0s7ok4uw	52	5	fission	fission	NN
cord-001835-0s7ok4uw	52	6	yeast	yeast	NN
cord-001835-0s7ok4uw	52	7	Schizosaccharomyces	Schizosaccharomyces	NNP
cord-001835-0s7ok4uw	52	8	pombe	pombe	NN
cord-001835-0s7ok4uw	52	9	encodes	encode	VBZ
cord-001835-0s7ok4uw	52	10	for	for	IN
cord-001835-0s7ok4uw	52	11	17	17	CD
cord-001835-0s7ok4uw	52	12	protein	protein	NN
cord-001835-0s7ok4uw	52	13	kinases	kinase	NNS
cord-001835-0s7ok4uw	52	14	that	that	WDT
cord-001835-0s7ok4uw	52	15	are	be	VBP
cord-001835-0s7ok4uw	52	16	essential	essential	JJ
cord-001835-0s7ok4uw	52	17	for	for	IN
cord-001835-0s7ok4uw	52	18	viability	viability	NN
cord-001835-0s7ok4uw	52	19	.	.	.
cord-001835-0s7ok4uw	53	1	Studies	study	NNS
cord-001835-0s7ok4uw	53	2	of	of	IN
cord-001835-0s7ok4uw	53	3	the	the	DT
cord-001835-0s7ok4uw	53	4	essential	essential	JJ
cord-001835-0s7ok4uw	53	5	kinases	kinase	NNS
cord-001835-0s7ok4uw	53	6	often	often	RB
cord-001835-0s7ok4uw	53	7	require	require	VBP
cord-001835-0s7ok4uw	53	8	the	the	DT
cord-001835-0s7ok4uw	53	9	use	use	NN
cord-001835-0s7ok4uw	53	10	of	of	IN
cord-001835-0s7ok4uw	53	11	mutant	mutant	JJ
cord-001835-0s7ok4uw	53	12	strains	strain	NNS
cord-001835-0s7ok4uw	53	13	carrying	carry	VBG
cord-001835-0s7ok4uw	53	14	conditional	conditional	JJ
cord-001835-0s7ok4uw	53	15	alleles	allele	NNS
cord-001835-0s7ok4uw	53	16	.	.	.
cord-001835-0s7ok4uw	54	1	To	to	TO
cord-001835-0s7ok4uw	54	2	inactivate	inactivate	VB
cord-001835-0s7ok4uw	54	3	these	these	DT
cord-001835-0s7ok4uw	54	4	kinases	kinase	NNS
cord-001835-0s7ok4uw	54	5	conditionally	conditionally	RB
cord-001835-0s7ok4uw	54	6	,	,	,
cord-001835-0s7ok4uw	54	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	54	8	applied	apply	VBD
cord-001835-0s7ok4uw	54	9	a	a	DT
cord-001835-0s7ok4uw	54	10	recently	recently	RB
cord-001835-0s7ok4uw	54	11	developed	develop	VBN
cord-001835-0s7ok4uw	54	12	chemical	chemical	JJ
cord-001835-0s7ok4uw	54	13	genetic	genetic	JJ
cord-001835-0s7ok4uw	54	14	strategy	strategy	NN
cord-001835-0s7ok4uw	54	15	.	.	.
cord-001835-0s7ok4uw	55	1	The	the	DT
cord-001835-0s7ok4uw	55	2	mutation	mutation	NN
cord-001835-0s7ok4uw	55	3	of	of	IN
cord-001835-0s7ok4uw	55	4	a	a	DT
cord-001835-0s7ok4uw	55	5	single	single	JJ
cord-001835-0s7ok4uw	55	6	residue	residue	NN
cord-001835-0s7ok4uw	55	7	in	in	IN
cord-001835-0s7ok4uw	55	8	the	the	DT
cord-001835-0s7ok4uw	55	9	ATP	ATP	NNP
cord-001835-0s7ok4uw	55	10	-	-	HYPH
cord-001835-0s7ok4uw	55	11	binding	bind	VBG
cord-001835-0s7ok4uw	55	12	pocket	pocket	NN
cord-001835-0s7ok4uw	55	13	confers	confer	VBZ
cord-001835-0s7ok4uw	55	14	sensitivity	sensitivity	NN
cord-001835-0s7ok4uw	55	15	to	to	IN
cord-001835-0s7ok4uw	55	16	small	small	JJ
cord-001835-0s7ok4uw	55	17	-	-	HYPH
cord-001835-0s7ok4uw	55	18	molecule	molecule	NN
cord-001835-0s7ok4uw	55	19	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	55	20	,	,	,
cord-001835-0s7ok4uw	55	21	allowing	allow	VBG
cord-001835-0s7ok4uw	55	22	for	for	IN
cord-001835-0s7ok4uw	55	23	specific	specific	JJ
cord-001835-0s7ok4uw	55	24	inactivation	inactivation	NN
cord-001835-0s7ok4uw	55	25	of	of	IN
cord-001835-0s7ok4uw	55	26	the	the	DT
cord-001835-0s7ok4uw	55	27	modified	modify	VBN
cord-001835-0s7ok4uw	55	28	kinase	kinase	NN
cord-001835-0s7ok4uw	55	29	.	.	.
cord-001835-0s7ok4uw	56	1	Using	use	VBG
cord-001835-0s7ok4uw	56	2	this	this	DT
cord-001835-0s7ok4uw	56	3	approach	approach	NN
cord-001835-0s7ok4uw	56	4	,	,	,
cord-001835-0s7ok4uw	56	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	56	6	constructed	construct	VBD
cord-001835-0s7ok4uw	56	7	conditional	conditional	JJ
cord-001835-0s7ok4uw	56	8	analog	analog	NN
cord-001835-0s7ok4uw	56	9	-	-	HYPH
cord-001835-0s7ok4uw	56	10	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	56	11	alleles	allele	NNS
cord-001835-0s7ok4uw	56	12	of	of	IN
cord-001835-0s7ok4uw	56	13	13	13	CD
cord-001835-0s7ok4uw	56	14	essential	essential	JJ
cord-001835-0s7ok4uw	56	15	protein	protein	NN
cord-001835-0s7ok4uw	56	16	kinases	kinase	NNS
cord-001835-0s7ok4uw	56	17	in	in	IN
cord-001835-0s7ok4uw	56	18	the	the	DT
cord-001835-0s7ok4uw	56	19	fission	fission	NN
cord-001835-0s7ok4uw	56	20	yeast	yeast	NN
cord-001835-0s7ok4uw	56	21	S.	S.	NNP
cord-001835-0s7ok4uw	56	22	pombe	pombe	NN
cord-001835-0s7ok4uw	56	23	.	.	.
cord-001835-0s7ok4uw	57	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	57	2	will	will	MD
cord-001835-0s7ok4uw	57	3	present	present	VB
cord-001835-0s7ok4uw	57	4	the	the	DT
cord-001835-0s7ok4uw	57	5	functional	functional	JJ
cord-001835-0s7ok4uw	57	6	analysis	analysis	NN
cord-001835-0s7ok4uw	57	7	of	of	IN
cord-001835-0s7ok4uw	57	8	these	these	DT
cord-001835-0s7ok4uw	57	9	mutants	mutant	NNS
cord-001835-0s7ok4uw	57	10	during	during	IN
cord-001835-0s7ok4uw	57	11	meiosis	meiosis	NN
cord-001835-0s7ok4uw	57	12	.	.	.
cord-001835-0s7ok4uw	58	1	Peptide	peptide	NN
cord-001835-0s7ok4uw	58	2	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	58	3	:	:	:
cord-001835-0s7ok4uw	59	1	From	from	IN
cord-001835-0s7ok4uw	59	2	self	self	NN
cord-001835-0s7ok4uw	59	3	-	-	HYPH
cord-001835-0s7ok4uw	59	4	assembly	assembly	NN
cord-001835-0s7ok4uw	59	5	towards	towards	IN
cord-001835-0s7ok4uw	59	6	applications	application	NNS
cord-001835-0s7ok4uw	59	7	in	in	IN
cord-001835-0s7ok4uw	59	8	biomedicine	biomedicine	NN
cord-001835-0s7ok4uw	59	9	Ian	Ian	NNP
cord-001835-0s7ok4uw	59	10	Hamley	Hamley	NNP
cord-001835-0s7ok4uw	59	11	1	1	CD
cord-001835-0s7ok4uw	59	12	1	1	CD
cord-001835-0s7ok4uw	59	13	University	University	NNP
cord-001835-0s7ok4uw	59	14	Of	of	IN
cord-001835-0s7ok4uw	59	15	Reading	Reading	NNP
cord-001835-0s7ok4uw	59	16	,	,	,
cord-001835-0s7ok4uw	60	1	Dept	Dept	NNP
cord-001835-0s7ok4uw	60	2	of	of	IN
cord-001835-0s7ok4uw	60	3	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	60	4	Self	Self	NNP
cord-001835-0s7ok4uw	60	5	-	-	HYPH
cord-001835-0s7ok4uw	60	6	assembling	assemble	VBG
cord-001835-0s7ok4uw	60	7	peptides	peptide	NNS
cord-001835-0s7ok4uw	60	8	and	and	CC
cord-001835-0s7ok4uw	60	9	their	-PRON-	PRP$
cord-001835-0s7ok4uw	60	10	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	60	11	offer	offer	VBP
cord-001835-0s7ok4uw	60	12	exceptional	exceptional	JJ
cord-001835-0s7ok4uw	60	13	potential	potential	NN
cord-001835-0s7ok4uw	60	14	in	in	IN
cord-001835-0s7ok4uw	60	15	nanomedicine	nanomedicine	NN
cord-001835-0s7ok4uw	60	16	.	.	.
cord-001835-0s7ok4uw	61	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	61	2	will	will	MD
cord-001835-0s7ok4uw	61	3	present	present	VB
cord-001835-0s7ok4uw	61	4	some	some	DT
cord-001835-0s7ok4uw	61	5	of	of	IN
cord-001835-0s7ok4uw	61	6	our	-PRON-	PRP$
cord-001835-0s7ok4uw	61	7	recent	recent	JJ
cord-001835-0s7ok4uw	61	8	work	work	NN
cord-001835-0s7ok4uw	61	9	on	on	IN
cord-001835-0s7ok4uw	61	10	nanoscale	nanoscale	NN
cord-001835-0s7ok4uw	61	11	assembled	assemble	VBN
cord-001835-0s7ok4uw	61	12	peptides	peptide	NNS
cord-001835-0s7ok4uw	61	13	and	and	CC
cord-001835-0s7ok4uw	61	14	their	-PRON-	PRP$
cord-001835-0s7ok4uw	61	15	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	61	16	,	,	,
cord-001835-0s7ok4uw	61	17	focussing	focusse	VBG
cord-001835-0s7ok4uw	61	18	on	on	IN
cord-001835-0s7ok4uw	61	19	lipopeptides	lipopeptide	NNS
cord-001835-0s7ok4uw	61	20	[	[	-LRB-
cord-001835-0s7ok4uw	61	21	1	1	CD
cord-001835-0s7ok4uw	61	22	,	,	,
cord-001835-0s7ok4uw	61	23	2	2	CD
cord-001835-0s7ok4uw	61	24	]	]	-RRB-
cord-001835-0s7ok4uw	61	25	and	and	CC
cord-001835-0s7ok4uw	61	26	PEG	peg	NN
cord-001835-0s7ok4uw	61	27	-	-	HYPH
cord-001835-0s7ok4uw	61	28	peptide	peptide	NN
cord-001835-0s7ok4uw	61	29	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	61	30	[	[	-LRB-
cord-001835-0s7ok4uw	61	31	3	3	CD
cord-001835-0s7ok4uw	61	32	]	]	-RRB-
cord-001835-0s7ok4uw	61	33	.	.	.
cord-001835-0s7ok4uw	62	1	PEGylation	pegylation	NN
cord-001835-0s7ok4uw	62	2	is	be	VBZ
cord-001835-0s7ok4uw	62	3	an	an	DT
cord-001835-0s7ok4uw	62	4	important	important	JJ
cord-001835-0s7ok4uw	62	5	technique	technique	NN
cord-001835-0s7ok4uw	62	6	in	in	IN
cord-001835-0s7ok4uw	62	7	the	the	DT
cord-001835-0s7ok4uw	62	8	development	development	NN
cord-001835-0s7ok4uw	62	9	of	of	IN
cord-001835-0s7ok4uw	62	10	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	62	11	for	for	IN
cord-001835-0s7ok4uw	62	12	applications	application	NNS
cord-001835-0s7ok4uw	62	13	in	in	IN
cord-001835-0s7ok4uw	62	14	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	62	15	.	.	.
cord-001835-0s7ok4uw	63	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	63	2	is	be	VBZ
cord-001835-0s7ok4uw	63	3	found	find	VBN
cord-001835-0s7ok4uw	63	4	to	to	TO
cord-001835-0s7ok4uw	63	5	greatly	greatly	RB
cord-001835-0s7ok4uw	63	6	influence	influence	VB
cord-001835-0s7ok4uw	63	7	self	self	NN
cord-001835-0s7ok4uw	63	8	-	-	HYPH
cord-001835-0s7ok4uw	63	9	assembly	assembly	NN
cord-001835-0s7ok4uw	63	10	of	of	IN
cord-001835-0s7ok4uw	63	11	peptides	peptide	NNS
cord-001835-0s7ok4uw	63	12	and	and	CC
cord-001835-0s7ok4uw	63	13	proteins	protein	NNS
cord-001835-0s7ok4uw	63	14	-one	-one	CD
cord-001835-0s7ok4uw	63	15	example	example	NN
cord-001835-0s7ok4uw	63	16	from	from	IN
cord-001835-0s7ok4uw	63	17	our	-PRON-	PRP$
cord-001835-0s7ok4uw	63	18	own	own	JJ
cord-001835-0s7ok4uw	63	19	work	work	NN
cord-001835-0s7ok4uw	63	20	is	be	VBZ
cord-001835-0s7ok4uw	63	21	a	a	DT
cord-001835-0s7ok4uw	63	22	peptide	peptide	NN
cord-001835-0s7ok4uw	63	23	which	which	WDT
cord-001835-0s7ok4uw	63	24	itself	-PRON-	PRP
cord-001835-0s7ok4uw	63	25	forms	form	VBZ
cord-001835-0s7ok4uw	63	26	twisted	twisted	JJ
cord-001835-0s7ok4uw	63	27	fibrils	fibril	NNS
cord-001835-0s7ok4uw	63	28	but	but	CC
cord-001835-0s7ok4uw	63	29	when	when	WRB
cord-001835-0s7ok4uw	63	30	PEG	PEG	NNP
cord-001835-0s7ok4uw	63	31	is	be	VBZ
cord-001835-0s7ok4uw	63	32	attached	attach	VBN
cord-001835-0s7ok4uw	63	33	,	,	,
cord-001835-0s7ok4uw	63	34	self	self	NN
cord-001835-0s7ok4uw	63	35	-	-	HYPH
cord-001835-0s7ok4uw	63	36	assembly	assembly	NN
cord-001835-0s7ok4uw	63	37	of	of	IN
cord-001835-0s7ok4uw	63	38	the	the	DT
cord-001835-0s7ok4uw	63	39	conjugate	conjugate	NN
cord-001835-0s7ok4uw	63	40	leads	lead	VBZ
cord-001835-0s7ok4uw	63	41	to	to	IN
cord-001835-0s7ok4uw	63	42	spherical	spherical	JJ
cord-001835-0s7ok4uw	63	43	micelles	micelle	NNS
cord-001835-0s7ok4uw	63	44	[	[	-LRB-
cord-001835-0s7ok4uw	63	45	4	4	CD
cord-001835-0s7ok4uw	63	46	]	]	-RRB-
cord-001835-0s7ok4uw	63	47	.	.	.
cord-001835-0s7ok4uw	64	1	The	the	DT
cord-001835-0s7ok4uw	64	2	conjugate	conjugate	NN
cord-001835-0s7ok4uw	64	3	can	can	MD
cord-001835-0s7ok4uw	64	4	be	be	VB
cord-001835-0s7ok4uw	64	5	enzymatically	enzymatically	RB
cord-001835-0s7ok4uw	64	6	degraded	degrade	VBN
cord-001835-0s7ok4uw	64	7	using	use	VBG
cord-001835-0s7ok4uw	64	8	alpha	alpha	NN
cord-001835-0s7ok4uw	64	9	-	-	HYPH
cord-001835-0s7ok4uw	64	10	chymotrypsin	chymotrypsin	NNP
cord-001835-0s7ok4uw	64	11	,	,	,
cord-001835-0s7ok4uw	64	12	releasing	release	VBG
cord-001835-0s7ok4uw	64	13	the	the	DT
cord-001835-0s7ok4uw	64	14	peptide	peptide	NN
cord-001835-0s7ok4uw	64	15	.	.	.
cord-001835-0s7ok4uw	65	1	This	this	DT
cord-001835-0s7ok4uw	65	2	nanocontainer	nanocontain	JJR
cord-001835-0s7ok4uw	65	3	delivery	delivery	NN
cord-001835-0s7ok4uw	65	4	and	and	CC
cord-001835-0s7ok4uw	65	5	release	release	NN
cord-001835-0s7ok4uw	65	6	system	system	NN
cord-001835-0s7ok4uw	65	7	could	could	MD
cord-001835-0s7ok4uw	65	8	be	be	VB
cord-001835-0s7ok4uw	65	9	useful	useful	JJ
cord-001835-0s7ok4uw	65	10	in	in	IN
cord-001835-0s7ok4uw	65	11	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	65	12	applications	application	NNS
cord-001835-0s7ok4uw	65	13	.	.	.
cord-001835-0s7ok4uw	66	1	Thermoresponsive	Thermoresponsive	NNP
cord-001835-0s7ok4uw	66	2	telechelic	telechelic	NN
cord-001835-0s7ok4uw	66	3	PEG	PEG	NNP
cord-001835-0s7ok4uw	66	4	/	/	,
cord-001835-0s7ok4uw	66	5	peptides	peptide	NNS
cord-001835-0s7ok4uw	66	6	with	with	IN
cord-001835-0s7ok4uw	66	7	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	66	8	dipeptide	dipeptide	NN
cord-001835-0s7ok4uw	66	9	end	end	NN
cord-001835-0s7ok4uw	66	10	groups	group	NNS
cord-001835-0s7ok4uw	67	1	(	(	-LRB-
cord-001835-0s7ok4uw	67	2	di	di	NN
cord-001835-0s7ok4uw	67	3	-	-	HYPH
cord-001835-0s7ok4uw	67	4	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	67	5	or	or	CC
cord-001835-0s7ok4uw	67	6	di	di	NN
cord-001835-0s7ok4uw	67	7	-	-	HYPH
cord-001835-0s7ok4uw	67	8	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	67	9	)	)	-RRB-
cord-001835-0s7ok4uw	67	10	were	be	VBD
cord-001835-0s7ok4uw	67	11	developed	develop	VBN
cord-001835-0s7ok4uw	67	12	,	,	,
cord-001835-0s7ok4uw	67	13	one	one	CD
cord-001835-0s7ok4uw	67	14	of	of	IN
cord-001835-0s7ok4uw	67	15	which	which	WDT
cord-001835-0s7ok4uw	67	16	shows	show	VBZ
cord-001835-0s7ok4uw	67	17	a	a	DT
cord-001835-0s7ok4uw	67	18	de	de	JJ
cord-001835-0s7ok4uw	67	19	-	-	NN
cord-001835-0s7ok4uw	67	20	gelation	gelation	JJ
cord-001835-0s7ok4uw	67	21	transition	transition	NN
cord-001835-0s7ok4uw	67	22	near	near	IN
cord-001835-0s7ok4uw	67	23	body	body	NN
cord-001835-0s7ok4uw	67	24	temperature	temperature	NN
cord-001835-0s7ok4uw	67	25	and	and	CC
cord-001835-0s7ok4uw	67	26	which	which	WDT
cord-001835-0s7ok4uw	67	27	may	may	MD
cord-001835-0s7ok4uw	67	28	be	be	VB
cord-001835-0s7ok4uw	67	29	useful	useful	JJ
cord-001835-0s7ok4uw	67	30	in	in	IN
cord-001835-0s7ok4uw	67	31	bioresponsive	bioresponsive	JJ
cord-001835-0s7ok4uw	67	32	delivery	delivery	NN
cord-001835-0s7ok4uw	67	33	systems	system	NNS
cord-001835-0s7ok4uw	67	34	[	[	-LRB-
cord-001835-0s7ok4uw	67	35	5	5	CD
cord-001835-0s7ok4uw	67	36	]	]	-RRB-
cord-001835-0s7ok4uw	67	37	.	.	.
cord-001835-0s7ok4uw	68	1	Examples	example	NNS
cord-001835-0s7ok4uw	68	2	from	from	IN
cord-001835-0s7ok4uw	68	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	68	4	recent	recent	JJ
cord-001835-0s7ok4uw	68	5	work	work	NN
cord-001835-0s7ok4uw	68	6	on	on	IN
cord-001835-0s7ok4uw	68	7	self	self	NN
cord-001835-0s7ok4uw	68	8	-	-	HYPH
cord-001835-0s7ok4uw	68	9	assembling	assemble	VBG
cord-001835-0s7ok4uw	68	10	lipopeptides	lipopeptide	NNS
cord-001835-0s7ok4uw	68	11	will	will	MD
cord-001835-0s7ok4uw	68	12	also	also	RB
cord-001835-0s7ok4uw	68	13	be	be	VB
cord-001835-0s7ok4uw	68	14	outlined	outline	VBN
cord-001835-0s7ok4uw	68	15	.	.	.
cord-001835-0s7ok4uw	69	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	69	2	focus	focus	NN
cord-001835-0s7ok4uw	69	3	is	be	VBZ
cord-001835-0s7ok4uw	69	4	to	to	TO
cord-001835-0s7ok4uw	69	5	investigate	investigate	VB
cord-001835-0s7ok4uw	69	6	potential	potential	JJ
cord-001835-0s7ok4uw	69	7	relationships	relationship	NNS
cord-001835-0s7ok4uw	69	8	between	between	IN
cord-001835-0s7ok4uw	69	9	self	self	NN
cord-001835-0s7ok4uw	69	10	-	-	HYPH
cord-001835-0s7ok4uw	69	11	assembly	assembly	NN
cord-001835-0s7ok4uw	69	12	and	and	CC
cord-001835-0s7ok4uw	69	13	bioactivity	bioactivity	NN
cord-001835-0s7ok4uw	69	14	,	,	,
cord-001835-0s7ok4uw	69	15	in	in	IN
cord-001835-0s7ok4uw	69	16	particular	particular	JJ
cord-001835-0s7ok4uw	69	17	in	in	IN
cord-001835-0s7ok4uw	69	18	the	the	DT
cord-001835-0s7ok4uw	69	19	fields	field	NNS
cord-001835-0s7ok4uw	69	20	of	of	IN
cord-001835-0s7ok4uw	69	21	regenerative	regenerative	JJ
cord-001835-0s7ok4uw	69	22	medicine	medicine	NN
cord-001835-0s7ok4uw	69	23	[	[	-LRB-
cord-001835-0s7ok4uw	69	24	6	6	CD
cord-001835-0s7ok4uw	69	25	]	]	-RRB-
cord-001835-0s7ok4uw	69	26	[	[	-LRB-
cord-001835-0s7ok4uw	69	27	7	7	CD
cord-001835-0s7ok4uw	69	28	]	]	-RRB-
cord-001835-0s7ok4uw	70	1	[	[	-LRB-
cord-001835-0s7ok4uw	70	2	8	8	CD
cord-001835-0s7ok4uw	70	3	]	]	-RRB-
cord-001835-0s7ok4uw	70	4	[	[	-LRB-
cord-001835-0s7ok4uw	70	5	9	9	CD
cord-001835-0s7ok4uw	70	6	]	]	-RRB-
cord-001835-0s7ok4uw	70	7	[	[	-LRB-
cord-001835-0s7ok4uw	70	8	10	10	CD
cord-001835-0s7ok4uw	70	9	]	]	-RRB-
cord-001835-0s7ok4uw	70	10	,	,	,
cord-001835-0s7ok4uw	70	11	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	70	12	systems	system	NNS
cord-001835-0s7ok4uw	70	13	[	[	-LRB-
cord-001835-0s7ok4uw	70	14	11	11	CD
cord-001835-0s7ok4uw	70	15	,	,	,
cord-001835-0s7ok4uw	70	16	12	12	CD
cord-001835-0s7ok4uw	70	17	]	]	-RRB-
cord-001835-0s7ok4uw	70	18	and	and	CC
cord-001835-0s7ok4uw	70	19	immune	immune	JJ
cord-001835-0s7ok4uw	70	20	therapies	therapy	NNS
cord-001835-0s7ok4uw	70	21	[	[	-LRB-
cord-001835-0s7ok4uw	70	22	13	13	CD
cord-001835-0s7ok4uw	70	23	]	]	-RRB-
cord-001835-0s7ok4uw	70	24	.	.	.
cord-001835-0s7ok4uw	71	1	been	be	VBN
cord-001835-0s7ok4uw	71	2	shown	show	VBN
cord-001835-0s7ok4uw	71	3	to	to	TO
cord-001835-0s7ok4uw	71	4	become	become	VB
cord-001835-0s7ok4uw	71	5	derivatized	derivatized	JJ
cord-001835-0s7ok4uw	71	6	with	with	IN
cord-001835-0s7ok4uw	71	7	argpyrimidine	argpyrimidine	NNP
cord-001835-0s7ok4uw	71	8	,	,	,
cord-001835-0s7ok4uw	71	9	a	a	DT
cord-001835-0s7ok4uw	71	10	prominent	prominent	JJ
cord-001835-0s7ok4uw	71	11	NEM	NEM	NNP
cord-001835-0s7ok4uw	71	12	that	that	WDT
cord-001835-0s7ok4uw	71	13	occurs	occur	VBZ
cord-001835-0s7ok4uw	71	14	on	on	IN
cord-001835-0s7ok4uw	71	15	arginine	arginine	NN
cord-001835-0s7ok4uw	71	16	residues	residue	NNS
cord-001835-0s7ok4uw	71	17	[	[	-LRB-
cord-001835-0s7ok4uw	71	18	6	6	CD
cord-001835-0s7ok4uw	71	19	]	]	-RRB-
cord-001835-0s7ok4uw	71	20	,	,	,
cord-001835-0s7ok4uw	71	21	in	in	IN
cord-001835-0s7ok4uw	71	22	certain	certain	JJ
cord-001835-0s7ok4uw	71	23	human	human	JJ
cord-001835-0s7ok4uw	71	24	cancer	cancer	NN
cord-001835-0s7ok4uw	71	25	tissues	tissue	NNS
cord-001835-0s7ok4uw	71	26	and	and	CC
cord-001835-0s7ok4uw	71	27	cell	cell	NN
cord-001835-0s7ok4uw	71	28	lines	line	NNS
cord-001835-0s7ok4uw	71	29	[	[	-LRB-
cord-001835-0s7ok4uw	71	30	7	7	CD
cord-001835-0s7ok4uw	71	31	,	,	,
cord-001835-0s7ok4uw	71	32	8	8	CD
cord-001835-0s7ok4uw	71	33	]	]	-RRB-
cord-001835-0s7ok4uw	71	34	.	.	.
cord-001835-0s7ok4uw	72	1	This	this	DT
cord-001835-0s7ok4uw	72	2	NEM	NEM	NNP
cord-001835-0s7ok4uw	72	3	was	be	VBD
cord-001835-0s7ok4uw	72	4	linked	link	VBN
cord-001835-0s7ok4uw	72	5	to	to	IN
cord-001835-0s7ok4uw	72	6	the	the	DT
cord-001835-0s7ok4uw	72	7	elevated	elevated	JJ
cord-001835-0s7ok4uw	72	8	antiapoptotic	antiapoptotic	JJ
cord-001835-0s7ok4uw	72	9	activity	activity	NN
cord-001835-0s7ok4uw	72	10	of	of	IN
cord-001835-0s7ok4uw	72	11	the	the	DT
cord-001835-0s7ok4uw	72	12	protein	protein	NN
cord-001835-0s7ok4uw	72	13	[	[	-LRB-
cord-001835-0s7ok4uw	72	14	7	7	CD
cord-001835-0s7ok4uw	72	15	,	,	,
cord-001835-0s7ok4uw	72	16	8	8	CD
cord-001835-0s7ok4uw	72	17	]	]	-RRB-
cord-001835-0s7ok4uw	72	18	,	,	,
cord-001835-0s7ok4uw	72	19	whereby	whereby	WRB
cord-001835-0s7ok4uw	72	20	modification	modification	NN
cord-001835-0s7ok4uw	72	21	of	of	IN
cord-001835-0s7ok4uw	72	22	Arg-188	arg-188	NN
cord-001835-0s7ok4uw	72	23	appeared	appear	VBD
cord-001835-0s7ok4uw	72	24	to	to	TO
cord-001835-0s7ok4uw	72	25	be	be	VB
cord-001835-0s7ok4uw	72	26	of	of	IN
cord-001835-0s7ok4uw	72	27	particular	particular	JJ
cord-001835-0s7ok4uw	72	28	significance	significance	NN
cord-001835-0s7ok4uw	72	29	[	[	-LRB-
cord-001835-0s7ok4uw	72	30	7	7	CD
cord-001835-0s7ok4uw	72	31	]	]	-RRB-
cord-001835-0s7ok4uw	72	32	.	.	.
cord-001835-0s7ok4uw	73	1	In	in	IN
cord-001835-0s7ok4uw	73	2	this	this	DT
cord-001835-0s7ok4uw	73	3	work	work	NN
cord-001835-0s7ok4uw	73	4	,	,	,
cord-001835-0s7ok4uw	73	5	Hsp27	Hsp27	NNP
cord-001835-0s7ok4uw	73	6	homogeneously	homogeneously	RB
cord-001835-0s7ok4uw	73	7	modified	modify	VBN
cord-001835-0s7ok4uw	73	8	with	with	IN
cord-001835-0s7ok4uw	73	9	argpyrimidine	argpyrimidine	NNP
cord-001835-0s7ok4uw	73	10	at	at	IN
cord-001835-0s7ok4uw	73	11	position	position	NN
cord-001835-0s7ok4uw	73	12	188	188	CD
cord-001835-0s7ok4uw	73	13	is	be	VBZ
cord-001835-0s7ok4uw	73	14	generated	generate	VBN
cord-001835-0s7ok4uw	73	15	for	for	IN
cord-001835-0s7ok4uw	73	16	the	the	DT
cord-001835-0s7ok4uw	73	17	first	first	JJ
cord-001835-0s7ok4uw	73	18	time	time	NN
cord-001835-0s7ok4uw	73	19	.	.	.
cord-001835-0s7ok4uw	74	1	Using	use	VBG
cord-001835-0s7ok4uw	74	2	expressed	express	VBD
cord-001835-0s7ok4uw	74	3	protein	protein	NN
cord-001835-0s7ok4uw	74	4	ligation	ligation	NN
cord-001835-0s7ok4uw	74	5	[	[	-LRB-
cord-001835-0s7ok4uw	74	6	9	9	CD
cord-001835-0s7ok4uw	74	7	]	]	-RRB-
cord-001835-0s7ok4uw	74	8	,	,	,
cord-001835-0s7ok4uw	74	9	the	the	DT
cord-001835-0s7ok4uw	74	10	first	first	JJ
cord-001835-0s7ok4uw	74	11	semisynthesis	semisynthesis	NN
cord-001835-0s7ok4uw	74	12	of	of	IN
cord-001835-0s7ok4uw	74	13	the	the	DT
cord-001835-0s7ok4uw	74	14	unmodified	unmodified	JJ
cord-001835-0s7ok4uw	74	15	protein	protein	NN
cord-001835-0s7ok4uw	74	16	is	be	VBZ
cord-001835-0s7ok4uw	74	17	achieved	achieve	VBN
cord-001835-0s7ok4uw	74	18	as	as	RB
cord-001835-0s7ok4uw	74	19	well	well	RB
cord-001835-0s7ok4uw	74	20	.	.	.
cord-001835-0s7ok4uw	75	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	75	2	approach	approach	NN
cord-001835-0s7ok4uw	75	3	,	,	,
cord-001835-0s7ok4uw	75	4	which	which	WDT
cord-001835-0s7ok4uw	75	5	combines	combine	VBZ
cord-001835-0s7ok4uw	75	6	organic	organic	JJ
cord-001835-0s7ok4uw	75	7	chemistry	chemistry	NN
cord-001835-0s7ok4uw	75	8	,	,	,
cord-001835-0s7ok4uw	75	9	peptide	peptide	NN
cord-001835-0s7ok4uw	75	10	synthesis	synthesis	NN
cord-001835-0s7ok4uw	75	11	and	and	CC
cord-001835-0s7ok4uw	75	12	protein	protein	NN
cord-001835-0s7ok4uw	75	13	synthesis	synthesis	NN
cord-001835-0s7ok4uw	75	14	,	,	,
cord-001835-0s7ok4uw	75	15	enables	enable	VBZ
cord-001835-0s7ok4uw	75	16	complete	complete	JJ
cord-001835-0s7ok4uw	75	17	control	control	NN
cord-001835-0s7ok4uw	75	18	over	over	IN
cord-001835-0s7ok4uw	75	19	protein	protein	NN
cord-001835-0s7ok4uw	75	20	composition	composition	NN
cord-001835-0s7ok4uw	75	21	and	and	CC
cord-001835-0s7ok4uw	75	22	thus	thus	RB
cord-001835-0s7ok4uw	75	23	can	can	MD
cord-001835-0s7ok4uw	75	24	provide	provide	VB
cord-001835-0s7ok4uw	75	25	previously	previously	RB
cord-001835-0s7ok4uw	75	26	unattainable	unattainable	JJ
cord-001835-0s7ok4uw	75	27	insight	insight	NN
cord-001835-0s7ok4uw	75	28	into	into	IN
cord-001835-0s7ok4uw	75	29	the	the	DT
cord-001835-0s7ok4uw	75	30	properties	property	NNS
cord-001835-0s7ok4uw	75	31	of	of	IN
cord-001835-0s7ok4uw	75	32	this	this	DT
cord-001835-0s7ok4uw	75	33	vital	vital	JJ
cord-001835-0s7ok4uw	75	34	chaperone	chaperone	NN
cord-001835-0s7ok4uw	75	35	following	follow	VBG
cord-001835-0s7ok4uw	75	36	nonenzymatic	nonenzymatic	JJ
cord-001835-0s7ok4uw	75	37	modification	modification	NN
cord-001835-0s7ok4uw	75	38	.	.	.
cord-001835-0s7ok4uw	76	1	The	the	DT
cord-001835-0s7ok4uw	76	2	synthesis	synthesis	NN
cord-001835-0s7ok4uw	76	3	of	of	IN
cord-001835-0s7ok4uw	76	4	argpyrimidine	argpyrimidine	NN
cord-001835-0s7ok4uw	76	5	-	-	HYPH
cord-001835-0s7ok4uw	76	6	modified	modify	VBN
cord-001835-0s7ok4uw	76	7	Hsp27	Hsp27	NNP
cord-001835-0s7ok4uw	76	8	and	and	CC
cord-001835-0s7ok4uw	76	9	the	the	DT
cord-001835-0s7ok4uw	76	10	progress	progress	NN
cord-001835-0s7ok4uw	76	11	towards	towards	IN
cord-001835-0s7ok4uw	76	12	structural	structural	JJ
cord-001835-0s7ok4uw	76	13	and	and	CC
cord-001835-0s7ok4uw	76	14	functional	functional	JJ
cord-001835-0s7ok4uw	76	15	characterization	characterization	NN
cord-001835-0s7ok4uw	76	16	of	of	IN
cord-001835-0s7ok4uw	76	17	the	the	DT
cord-001835-0s7ok4uw	76	18	protein	protein	NN
cord-001835-0s7ok4uw	76	19	will	will	MD
cord-001835-0s7ok4uw	76	20	be	be	VB
cord-001835-0s7ok4uw	76	21	presented	present	VBN
cord-001835-0s7ok4uw	76	22	herein	herein	RB
cord-001835-0s7ok4uw	76	23	.	.	.
cord-001835-0s7ok4uw	76	24	 	 	_SP
cord-001835-0s7ok4uw	77	1	Kunitz	Kunitz	NNP
cord-001835-0s7ok4uw	77	2	-	-	HYPH
cord-001835-0s7ok4uw	77	3	type	type	NN
cord-001835-0s7ok4uw	77	4	protease	protease	NN
cord-001835-0s7ok4uw	77	5	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	77	6	belong	belong	VBP
cord-001835-0s7ok4uw	77	7	to	to	IN
cord-001835-0s7ok4uw	77	8	a	a	DT
cord-001835-0s7ok4uw	77	9	widespread	widespread	JJ
cord-001835-0s7ok4uw	77	10	protein	protein	NN
cord-001835-0s7ok4uw	77	11	family	family	NN
cord-001835-0s7ok4uw	77	12	present	present	JJ
cord-001835-0s7ok4uw	77	13	in	in	IN
cord-001835-0s7ok4uw	77	14	many	many	JJ
cord-001835-0s7ok4uw	77	15	plant	plant	NN
cord-001835-0s7ok4uw	77	16	species	specie	NNS
cord-001835-0s7ok4uw	77	17	and	and	CC
cord-001835-0s7ok4uw	77	18	play	play	VB
cord-001835-0s7ok4uw	77	19	an	an	DT
cord-001835-0s7ok4uw	77	20	important	important	JJ
cord-001835-0s7ok4uw	77	21	role	role	NN
cord-001835-0s7ok4uw	77	22	in	in	IN
cord-001835-0s7ok4uw	77	23	plant	plant	NN
cord-001835-0s7ok4uw	77	24	defense	defense	NN
cord-001835-0s7ok4uw	77	25	against	against	IN
cord-001835-0s7ok4uw	77	26	insect	insect	NN
cord-001835-0s7ok4uw	77	27	pests	pest	NNS
cord-001835-0s7ok4uw	77	28	and	and	CC
cord-001835-0s7ok4uw	77	29	pathogens	pathogen	NNS
cord-001835-0s7ok4uw	77	30	.	.	.
cord-001835-0s7ok4uw	78	1	Members	member	NNS
cord-001835-0s7ok4uw	78	2	of	of	IN
cord-001835-0s7ok4uw	78	3	this	this	DT
cord-001835-0s7ok4uw	78	4	family	family	NN
cord-001835-0s7ok4uw	78	5	are	be	VBP
cord-001835-0s7ok4uw	78	6	typically	typically	RB
cord-001835-0s7ok4uw	78	7	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	78	8	of	of	IN
cord-001835-0s7ok4uw	78	9	proteases	protease	NNS
cord-001835-0s7ok4uw	78	10	of	of	IN
cord-001835-0s7ok4uw	78	11	serine	serine	JJ
cord-001835-0s7ok4uw	78	12	class	class	NN
cord-001835-0s7ok4uw	78	13	.	.	.
cord-001835-0s7ok4uw	79	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	79	2	,	,	,
cord-001835-0s7ok4uw	79	3	a	a	DT
cord-001835-0s7ok4uw	79	4	few	few	JJ
cord-001835-0s7ok4uw	79	5	members	member	NNS
cord-001835-0s7ok4uw	79	6	were	be	VBD
cord-001835-0s7ok4uw	79	7	identified	identify	VBN
cord-001835-0s7ok4uw	79	8	as	as	IN
cord-001835-0s7ok4uw	79	9	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	79	10	of	of	IN
cord-001835-0s7ok4uw	79	11	proteases	protease	NNS
cord-001835-0s7ok4uw	79	12	of	of	IN
cord-001835-0s7ok4uw	79	13	cysteine	cysteine	NN
cord-001835-0s7ok4uw	79	14	class	class	NN
cord-001835-0s7ok4uw	79	15	,	,	,
cord-001835-0s7ok4uw	79	16	however	however	RB
cord-001835-0s7ok4uw	79	17	,	,	,
cord-001835-0s7ok4uw	79	18	they	-PRON-	PRP
cord-001835-0s7ok4uw	79	19	have	have	VBP
cord-001835-0s7ok4uw	79	20	not	not	RB
cord-001835-0s7ok4uw	79	21	been	be	VBN
cord-001835-0s7ok4uw	79	22	functionally	functionally	RB
cord-001835-0s7ok4uw	79	23	and	and	CC
cord-001835-0s7ok4uw	79	24	structurally	structurally	RB
cord-001835-0s7ok4uw	79	25	characterized	characterize	VBN
cord-001835-0s7ok4uw	79	26	.	.	.
cord-001835-0s7ok4uw	80	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	80	2	study	study	NN
cord-001835-0s7ok4uw	80	3	is	be	VBZ
cord-001835-0s7ok4uw	80	4	focused	focus	VBN
cord-001835-0s7ok4uw	80	5	on	on	IN
cord-001835-0s7ok4uw	80	6	Kunitz	Kunitz	NNP
cord-001835-0s7ok4uw	80	7	-	-	HYPH
cord-001835-0s7ok4uw	80	8	type	type	NN
cord-001835-0s7ok4uw	80	9	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	80	10	of	of	IN
cord-001835-0s7ok4uw	80	11	cysteine	cysteine	NN
cord-001835-0s7ok4uw	80	12	proteases	protease	NNS
cord-001835-0s7ok4uw	80	13	(	(	-LRB-
cord-001835-0s7ok4uw	80	14	PCPIs	pcpi	NNS
cord-001835-0s7ok4uw	80	15	)	)	-RRB-
cord-001835-0s7ok4uw	80	16	from	from	IN
cord-001835-0s7ok4uw	80	17	potato	potato	NN
cord-001835-0s7ok4uw	80	18	(	(	-LRB-
cord-001835-0s7ok4uw	80	19	Solanum	Solanum	NNP
cord-001835-0s7ok4uw	80	20	tuberosum	tuberosum	NN
cord-001835-0s7ok4uw	80	21	)	)	-RRB-
cord-001835-0s7ok4uw	80	22	.	.	.
cord-001835-0s7ok4uw	81	1	A	a	DT
cord-001835-0s7ok4uw	81	2	series	series	NN
cord-001835-0s7ok4uw	81	3	of	of	IN
cord-001835-0s7ok4uw	81	4	20	20	CD
cord-001835-0s7ok4uw	81	5	kDa	kDa	NNP
cord-001835-0s7ok4uw	81	6	PCPIs	pcpi	NNS
cord-001835-0s7ok4uw	81	7	was	be	VBD
cord-001835-0s7ok4uw	81	8	purified	purify	VBN
cord-001835-0s7ok4uw	81	9	using	use	VBG
cord-001835-0s7ok4uw	81	10	a	a	DT
cord-001835-0s7ok4uw	81	11	multi	multi	JJ
cord-001835-0s7ok4uw	81	12	-	-	JJ
cord-001835-0s7ok4uw	81	13	step	step	JJ
cord-001835-0s7ok4uw	81	14	chromatographical	chromatographical	NN
cord-001835-0s7ok4uw	81	15	protocol	protocol	NN
cord-001835-0s7ok4uw	81	16	,	,	,
cord-001835-0s7ok4uw	81	17	and	and	CC
cord-001835-0s7ok4uw	81	18	two	two	CD
cord-001835-0s7ok4uw	81	19	most	most	RBS
cord-001835-0s7ok4uw	81	20	abundant	abundant	JJ
cord-001835-0s7ok4uw	81	21	and	and	CC
cord-001835-0s7ok4uw	81	22	effective	effective	JJ
cord-001835-0s7ok4uw	81	23	isoinhibitors	isoinhibitor	NNS
cord-001835-0s7ok4uw	81	24	named	name	VBN
cord-001835-0s7ok4uw	81	25	PCI	PCI	NNP
cord-001835-0s7ok4uw	81	26	1	1	CD
cord-001835-0s7ok4uw	81	27	-	-	SYM
cord-001835-0s7ok4uw	81	28	5	5	CD
cord-001835-0s7ok4uw	81	29	and	and	CC
cord-001835-0s7ok4uw	81	30	PCI	PCI	NNP
cord-001835-0s7ok4uw	81	31	3	3	CD
cord-001835-0s7ok4uw	81	32	were	be	VBD
cord-001835-0s7ok4uw	81	33	characterized	characterize	VBN
cord-001835-0s7ok4uw	81	34	in	in	IN
cord-001835-0s7ok4uw	81	35	detail	detail	NN
cord-001835-0s7ok4uw	81	36	.	.	.
cord-001835-0s7ok4uw	82	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	82	2	were	be	VBD
cord-001835-0s7ok4uw	82	3	screened	screen	VBN
cord-001835-0s7ok4uw	82	4	against	against	IN
cord-001835-0s7ok4uw	82	5	a	a	DT
cord-001835-0s7ok4uw	82	6	broad	broad	JJ
cord-001835-0s7ok4uw	82	7	panel	panel	NN
cord-001835-0s7ok4uw	82	8	of	of	IN
cord-001835-0s7ok4uw	82	9	model	model	NN
cord-001835-0s7ok4uw	82	10	cysteine	cysteine	NN
cord-001835-0s7ok4uw	82	11	proteases	protease	NNS
cord-001835-0s7ok4uw	82	12	and	and	CC
cord-001835-0s7ok4uw	82	13	digestive	digestive	JJ
cord-001835-0s7ok4uw	82	14	cysteine	cysteine	NN
cord-001835-0s7ok4uw	82	15	proteases	protease	NNS
cord-001835-0s7ok4uw	82	16	from	from	IN
cord-001835-0s7ok4uw	82	17	herbivorous	herbivorous	JJ
cord-001835-0s7ok4uw	82	18	insects	insect	NNS
cord-001835-0s7ok4uw	82	19	.	.	.
cord-001835-0s7ok4uw	83	1	PCI	PCI	NNP
cord-001835-0s7ok4uw	83	2	1	1	CD
cord-001835-0s7ok4uw	83	3	-	-	SYM
cord-001835-0s7ok4uw	83	4	5	5	CD
cord-001835-0s7ok4uw	83	5	and	and	CC
cord-001835-0s7ok4uw	83	6	PCI	PCI	NNP
cord-001835-0s7ok4uw	83	7	3	3	CD
cord-001835-0s7ok4uw	83	8	exhibit	exhibit	VBP
cord-001835-0s7ok4uw	83	9	different	different	JJ
cord-001835-0s7ok4uw	83	10	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	83	11	specificity	specificity	NN
cord-001835-0s7ok4uw	83	12	pattern	pattern	NN
cord-001835-0s7ok4uw	83	13	and	and	CC
cord-001835-0s7ok4uw	83	14	potency	potency	NN
cord-001835-0s7ok4uw	83	15	up	up	RP
cord-001835-0s7ok4uw	83	16	to	to	IN
cord-001835-0s7ok4uw	83	17	the	the	DT
cord-001835-0s7ok4uw	83	18	nanomolar	nanomolar	JJ
cord-001835-0s7ok4uw	83	19	range	range	NN
cord-001835-0s7ok4uw	83	20	.	.	.
cord-001835-0s7ok4uw	84	1	Both	both	DT
cord-001835-0s7ok4uw	84	2	isoinhibitors	isoinhibitor	NNS
cord-001835-0s7ok4uw	84	3	were	be	VBD
cord-001835-0s7ok4uw	84	4	crystallized	crystallize	VBN
cord-001835-0s7ok4uw	84	5	and	and	CC
cord-001835-0s7ok4uw	84	6	their	-PRON-	PRP$
cord-001835-0s7ok4uw	84	7	spatial	spatial	JJ
cord-001835-0s7ok4uw	84	8	structures	structure	NNS
cord-001835-0s7ok4uw	84	9	were	be	VBD
cord-001835-0s7ok4uw	84	10	solved	solve	VBN
cord-001835-0s7ok4uw	84	11	and	and	CC
cord-001835-0s7ok4uw	84	12	refined	refine	VBN
cord-001835-0s7ok4uw	84	13	at	at	IN
cord-001835-0s7ok4uw	84	14	1.5	1.5	CD
cord-001835-0s7ok4uw	84	15	Å	å	NN
cord-001835-0s7ok4uw	84	16	(	(	-LRB-
cord-001835-0s7ok4uw	84	17	PCI	PCI	NNP
cord-001835-0s7ok4uw	84	18	1	1	CD
cord-001835-0s7ok4uw	84	19	-	-	SYM
cord-001835-0s7ok4uw	84	20	5	5	CD
cord-001835-0s7ok4uw	84	21	)	)	-RRB-
cord-001835-0s7ok4uw	84	22	and	and	CC
cord-001835-0s7ok4uw	84	23	1.7	1.7	CD
cord-001835-0s7ok4uw	84	24	Å	å	NN
cord-001835-0s7ok4uw	84	25	(	(	-LRB-
cord-001835-0s7ok4uw	84	26	PCI	PCI	NNP
cord-001835-0s7ok4uw	84	27	3	3	CD
cord-001835-0s7ok4uw	84	28	)	)	-RRB-
cord-001835-0s7ok4uw	84	29	resolutions	resolution	NNS
cord-001835-0s7ok4uw	84	30	.	.	.
cord-001835-0s7ok4uw	85	1	A	a	DT
cord-001835-0s7ok4uw	85	2	position	position	NN
cord-001835-0s7ok4uw	85	3	of	of	IN
cord-001835-0s7ok4uw	85	4	reactive	reactive	JJ
cord-001835-0s7ok4uw	85	5	sites	site	NNS
cord-001835-0s7ok4uw	85	6	against	against	IN
cord-001835-0s7ok4uw	85	7	cysteine	cysteine	NN
cord-001835-0s7ok4uw	85	8	proteases	protease	NNS
cord-001835-0s7ok4uw	85	9	on	on	IN
cord-001835-0s7ok4uw	85	10	the	the	DT
cord-001835-0s7ok4uw	85	11	conserved	conserve	VBN
cord-001835-0s7ok4uw	85	12	b	b	NN
cord-001835-0s7ok4uw	85	13	-	-	HYPH
cord-001835-0s7ok4uw	85	14	trefoil	trefoil	NN
cord-001835-0s7ok4uw	85	15	fold	fold	JJ
cord-001835-0s7ok4uw	85	16	scaffold	scaffold	NN
cord-001835-0s7ok4uw	85	17	was	be	VBD
cord-001835-0s7ok4uw	85	18	proposed	propose	VBN
cord-001835-0s7ok4uw	85	19	.	.	.
cord-001835-0s7ok4uw	86	1	The	the	DT
cord-001835-0s7ok4uw	86	2	work	work	NN
cord-001835-0s7ok4uw	86	3	provides	provide	VBZ
cord-001835-0s7ok4uw	86	4	the	the	DT
cord-001835-0s7ok4uw	86	5	first	first	JJ
cord-001835-0s7ok4uw	86	6	analysis	analysis	NN
cord-001835-0s7ok4uw	86	7	of	of	IN
cord-001835-0s7ok4uw	86	8	PCPIs	pcpi	NNS
cord-001835-0s7ok4uw	86	9	with	with	IN
cord-001835-0s7ok4uw	86	10	respect	respect	NN
cord-001835-0s7ok4uw	86	11	to	to	IN
cord-001835-0s7ok4uw	86	12	the	the	DT
cord-001835-0s7ok4uw	86	13	structure	structure	NN
cord-001835-0s7ok4uw	86	14	-	-	HYPH
cord-001835-0s7ok4uw	86	15	function	function	NN
cord-001835-0s7ok4uw	86	16	relationships	relationship	NNS
cord-001835-0s7ok4uw	86	17	and	and	CC
cord-001835-0s7ok4uw	86	18	evolution	evolution	NN
cord-001835-0s7ok4uw	86	19	within	within	IN
cord-001835-0s7ok4uw	86	20	the	the	DT
cord-001835-0s7ok4uw	86	21	Kunitz	Kunitz	NNP
cord-001835-0s7ok4uw	86	22	-	-	HYPH
cord-001835-0s7ok4uw	86	23	type	type	NN
cord-001835-0s7ok4uw	86	24	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	86	25	family	family	NN
cord-001835-0s7ok4uw	86	26	.	.	.
cord-001835-0s7ok4uw	87	1	Role	role	NN
cord-001835-0s7ok4uw	87	2	of	of	IN
cord-001835-0s7ok4uw	87	3	the	the	DT
cord-001835-0s7ok4uw	87	4	ABCC2	abcc2	NN
cord-001835-0s7ok4uw	87	5	transporter	transporter	NN
cord-001835-0s7ok4uw	87	6	in	in	IN
cord-001835-0s7ok4uw	87	7	the	the	DT
cord-001835-0s7ok4uw	87	8	mode	mode	NN
cord-001835-0s7ok4uw	87	9	of	of	IN
cord-001835-0s7ok4uw	87	10	action	action	NN
cord-001835-0s7ok4uw	87	11	of	of	IN
cord-001835-0s7ok4uw	87	12	the	the	DT
cord-001835-0s7ok4uw	87	13	Bacillus	Bacillus	NNP
cord-001835-0s7ok4uw	87	14	thuringiensis	thuringiensis	NN
cord-001835-0s7ok4uw	87	15	Cry1Ac	Cry1Ac	NNP
cord-001835-0s7ok4uw	87	16	toxin	toxin	NN
cord-001835-0s7ok4uw	87	17	in	in	IN
cord-001835-0s7ok4uw	87	18	the	the	DT
cord-001835-0s7ok4uw	87	19	Diamond	Diamond	NNP
cord-001835-0s7ok4uw	87	20	Back	Back	NNP
cord-001835-0s7ok4uw	87	21	Moth	Moth	NNP
cord-001835-0s7ok4uw	87	22	Plutella	Plutella	NNP
cord-001835-0s7ok4uw	87	23	xylostella	xylostella	NN
cord-001835-0s7ok4uw	87	24	1	1	CD
cord-001835-0s7ok4uw	87	25	 	 	_SP
cord-001835-0s7ok4uw	87	26	Protonation	Protonation	NNP
cord-001835-0s7ok4uw	87	27	pattern	pattern	NN
cord-001835-0s7ok4uw	87	28	influence	influence	NN
cord-001835-0s7ok4uw	87	29	actively	actively	RB
cord-001835-0s7ok4uw	87	30	properties	property	NNS
cord-001835-0s7ok4uw	87	31	of	of	IN
cord-001835-0s7ok4uw	87	32	molecules	molecule	NNS
cord-001835-0s7ok4uw	87	33	and	and	CC
cord-001835-0s7ok4uw	87	34	play	play	VB
cord-001835-0s7ok4uw	87	35	an	an	DT
cord-001835-0s7ok4uw	87	36	essential	essential	JJ
cord-001835-0s7ok4uw	87	37	role	role	NN
cord-001835-0s7ok4uw	87	38	in	in	IN
cord-001835-0s7ok4uw	87	39	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	87	40	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	87	41	.	.	.
cord-001835-0s7ok4uw	88	1	For	for	IN
cord-001835-0s7ok4uw	88	2	an	an	DT
cord-001835-0s7ok4uw	88	3	accurate	accurate	JJ
cord-001835-0s7ok4uw	88	4	determination	determination	NN
cord-001835-0s7ok4uw	88	5	of	of	IN
cord-001835-0s7ok4uw	88	6	the	the	DT
cord-001835-0s7ok4uw	88	7	protonation	protonation	NN
cord-001835-0s7ok4uw	88	8	equilibria	equilibrium	NNS
cord-001835-0s7ok4uw	88	9	,	,	,
cord-001835-0s7ok4uw	88	10	the	the	DT
cord-001835-0s7ok4uw	88	11	absolute	absolute	JJ
cord-001835-0s7ok4uw	88	12	proton	proton	NN
cord-001835-0s7ok4uw	88	13	solvation	solvation	NN
cord-001835-0s7ok4uw	88	14	free	free	JJ
cord-001835-0s7ok4uw	88	15	energy	energy	NN
cord-001835-0s7ok4uw	88	16	needs	need	VBZ
cord-001835-0s7ok4uw	88	17	to	to	TO
cord-001835-0s7ok4uw	88	18	be	be	VB
cord-001835-0s7ok4uw	88	19	known	know	VBN
cord-001835-0s7ok4uw	88	20	.	.	.
cord-001835-0s7ok4uw	89	1	The	the	DT
cord-001835-0s7ok4uw	89	2	determination	determination	NN
cord-001835-0s7ok4uw	89	3	of	of	IN
cord-001835-0s7ok4uw	89	4	this	this	DT
cord-001835-0s7ok4uw	89	5	energy	energy	NN
cord-001835-0s7ok4uw	89	6	represents	represent	VBZ
cord-001835-0s7ok4uw	89	7	one	one	CD
cord-001835-0s7ok4uw	89	8	of	of	IN
cord-001835-0s7ok4uw	89	9	the	the	DT
cord-001835-0s7ok4uw	89	10	most	most	RBS
cord-001835-0s7ok4uw	89	11	challenging	challenging	JJ
cord-001835-0s7ok4uw	89	12	problems	problem	NNS
cord-001835-0s7ok4uw	89	13	in	in	IN
cord-001835-0s7ok4uw	89	14	physical	physical	JJ
cord-001835-0s7ok4uw	89	15	chemistry	chemistry	NN
cord-001835-0s7ok4uw	89	16	.	.	.
cord-001835-0s7ok4uw	90	1	This	this	DT
cord-001835-0s7ok4uw	90	2	is	be	VBZ
cord-001835-0s7ok4uw	90	3	particularly	particularly	RB
cord-001835-0s7ok4uw	90	4	difficult	difficult	JJ
cord-001835-0s7ok4uw	90	5	for	for	IN
cord-001835-0s7ok4uw	90	6	protons	proton	NNS
cord-001835-0s7ok4uw	90	7	solvated	solvate	VBN
cord-001835-0s7ok4uw	90	8	in	in	IN
cord-001835-0s7ok4uw	90	9	water	water	NN
cord-001835-0s7ok4uw	90	10	,	,	,
cord-001835-0s7ok4uw	90	11	where	where	WRB
cord-001835-0s7ok4uw	90	12	the	the	DT
cord-001835-0s7ok4uw	90	13	solvation	solvation	NN
cord-001835-0s7ok4uw	90	14	is	be	VBZ
cord-001835-0s7ok4uw	90	15	dynamically	dynamically	RB
cord-001835-0s7ok4uw	90	16	performed	perform	VBN
cord-001835-0s7ok4uw	90	17	by	by	IN
cord-001835-0s7ok4uw	90	18	different	different	JJ
cord-001835-0s7ok4uw	90	19	water	water	NN
cord-001835-0s7ok4uw	90	20	clusters	cluster	NNS
cord-001835-0s7ok4uw	90	21	and	and	CC
cord-001835-0s7ok4uw	90	22	the	the	DT
cord-001835-0s7ok4uw	90	23	proton	proton	NN
cord-001835-0s7ok4uw	90	24	is	be	VBZ
cord-001835-0s7ok4uw	90	25	not	not	RB
cord-001835-0s7ok4uw	90	26	attached	attach	VBN
cord-001835-0s7ok4uw	90	27	to	to	IN
cord-001835-0s7ok4uw	90	28	a	a	DT
cord-001835-0s7ok4uw	90	29	single	single	JJ
cord-001835-0s7ok4uw	90	30	solvent	solvent	NN
cord-001835-0s7ok4uw	90	31	molecule	molecule	NN
cord-001835-0s7ok4uw	90	32	.	.	.
cord-001835-0s7ok4uw	91	1	The	the	DT
cord-001835-0s7ok4uw	91	2	proton	proton	NN
cord-001835-0s7ok4uw	91	3	solvation	solvation	NN
cord-001835-0s7ok4uw	91	4	is	be	VBZ
cord-001835-0s7ok4uw	91	5	notably	notably	RB
cord-001835-0s7ok4uw	91	6	important	important	JJ
cord-001835-0s7ok4uw	91	7	in	in	IN
cord-001835-0s7ok4uw	91	8	order	order	NN
cord-001835-0s7ok4uw	91	9	to	to	TO
cord-001835-0s7ok4uw	91	10	quantify	quantify	VB
cord-001835-0s7ok4uw	91	11	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	91	12	of	of	IN
cord-001835-0s7ok4uw	91	13	proton	proton	NN
cord-001835-0s7ok4uw	91	14	transfer	transfer	NN
cord-001835-0s7ok4uw	91	15	and	and	CC
cord-001835-0s7ok4uw	91	16	such	such	JJ
cord-001835-0s7ok4uw	91	17	processes	process	NNS
cord-001835-0s7ok4uw	91	18	have	have	VBP
cord-001835-0s7ok4uw	91	19	been	be	VBN
cord-001835-0s7ok4uw	91	20	investigated	investigate	VBN
cord-001835-0s7ok4uw	91	21	for	for	IN
cord-001835-0s7ok4uw	91	22	a	a	DT
cord-001835-0s7ok4uw	91	23	long	long	JJ
cord-001835-0s7ok4uw	91	24	time	time	NN
cord-001835-0s7ok4uw	91	25	based	base	VBN
cord-001835-0s7ok4uw	91	26	on	on	IN
cord-001835-0s7ok4uw	91	27	different	different	JJ
cord-001835-0s7ok4uw	91	28	approaches	approach	NNS
cord-001835-0s7ok4uw	91	29	,	,	,
cord-001835-0s7ok4uw	91	30	often	often	RB
cord-001835-0s7ok4uw	91	31	leading	lead	VBG
cord-001835-0s7ok4uw	91	32	to	to	IN
cord-001835-0s7ok4uw	91	33	contradictory	contradictory	JJ
cord-001835-0s7ok4uw	91	34	conclusions	conclusion	NNS
cord-001835-0s7ok4uw	91	35	.	.	.
cord-001835-0s7ok4uw	92	1	A	a	DT
cord-001835-0s7ok4uw	92	2	rigorous	rigorous	JJ
cord-001835-0s7ok4uw	92	3	and	and	CC
cord-001835-0s7ok4uw	92	4	accurate	accurate	JJ
cord-001835-0s7ok4uw	92	5	protocol	protocol	NN
cord-001835-0s7ok4uw	92	6	for	for	IN
cord-001835-0s7ok4uw	92	7	computing	compute	VBG
cord-001835-0s7ok4uw	92	8	proton	proton	NN
cord-001835-0s7ok4uw	92	9	solvation	solvation	NN
cord-001835-0s7ok4uw	92	10	in	in	IN
cord-001835-0s7ok4uw	92	11	solvents	solvent	NNS
cord-001835-0s7ok4uw	92	12	of	of	IN
cord-001835-0s7ok4uw	92	13	different	different	JJ
cord-001835-0s7ok4uw	92	14	nature	nature	NN
cord-001835-0s7ok4uw	92	15	is	be	VBZ
cord-001835-0s7ok4uw	92	16	of	of	IN
cord-001835-0s7ok4uw	92	17	prime	prime	JJ
cord-001835-0s7ok4uw	92	18	importance	importance	NN
cord-001835-0s7ok4uw	92	19	for	for	IN
cord-001835-0s7ok4uw	92	20	applied	apply	VBN
cord-001835-0s7ok4uw	92	21	(	(	-LRB-
cord-001835-0s7ok4uw	92	22	pharmaceutical	pharmaceutical	NN
cord-001835-0s7ok4uw	92	23	and	and	CC
cord-001835-0s7ok4uw	92	24	material	material	NN
cord-001835-0s7ok4uw	92	25	science	science	NN
cord-001835-0s7ok4uw	92	26	)	)	-RRB-
cord-001835-0s7ok4uw	92	27	and	and	CC
cord-001835-0s7ok4uw	92	28	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	92	29	sciences	science	NNS
cord-001835-0s7ok4uw	92	30	.	.	.
cord-001835-0s7ok4uw	93	1	In	in	IN
cord-001835-0s7ok4uw	93	2	this	this	DT
cord-001835-0s7ok4uw	93	3	study	study	NN
cord-001835-0s7ok4uw	93	4	,	,	,
cord-001835-0s7ok4uw	93	5	proton	proton	NN
cord-001835-0s7ok4uw	93	6	affinities	affinity	NNS
cord-001835-0s7ok4uw	93	7	,	,	,
cord-001835-0s7ok4uw	93	8	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	93	9	energies	energy	NNS
cord-001835-0s7ok4uw	93	10	of	of	IN
cord-001835-0s7ok4uw	93	11	solvation	solvation	NN
cord-001835-0s7ok4uw	93	12	and	and	CC
cord-001835-0s7ok4uw	93	13	pKa	pKa	NNP
cord-001835-0s7ok4uw	93	14	values	value	NNS
cord-001835-0s7ok4uw	93	15	of	of	IN
cord-001835-0s7ok4uw	93	16	a	a	DT
cord-001835-0s7ok4uw	93	17	reference	reference	NN
cord-001835-0s7ok4uw	93	18	set	set	VBN
cord-001835-0s7ok4uw	93	19	of	of	IN
cord-001835-0s7ok4uw	93	20	organic	organic	JJ
cord-001835-0s7ok4uw	93	21	molecules	molecule	NNS
cord-001835-0s7ok4uw	93	22	are	be	VBP
cord-001835-0s7ok4uw	93	23	computed	compute	VBN
cord-001835-0s7ok4uw	93	24	in	in	IN
cord-001835-0s7ok4uw	93	25	protic	protic	JJ
cord-001835-0s7ok4uw	93	26	and	and	CC
cord-001835-0s7ok4uw	93	27	aprotic	aprotic	JJ
cord-001835-0s7ok4uw	93	28	solvents	solvent	NNS
cord-001835-0s7ok4uw	93	29	.	.	.
cord-001835-0s7ok4uw	94	1	Proportional	proportional	JJ
cord-001835-0s7ok4uw	94	2	to	to	IN
cord-001835-0s7ok4uw	94	3	the	the	DT
cord-001835-0s7ok4uw	94	4	free	free	JJ
cord-001835-0s7ok4uw	94	5	energy	energy	NN
cord-001835-0s7ok4uw	94	6	of	of	IN
cord-001835-0s7ok4uw	94	7	proton	proton	NN
cord-001835-0s7ok4uw	94	8	dissociation	dissociation	NN
cord-001835-0s7ok4uw	94	9	,	,	,
cord-001835-0s7ok4uw	94	10	the	the	DT
cord-001835-0s7ok4uw	94	11	pKa	pKa	NNP
cord-001835-0s7ok4uw	94	12	value	value	NN
cord-001835-0s7ok4uw	94	13	calculation	calculation	NN
cord-001835-0s7ok4uw	94	14	is	be	VBZ
cord-001835-0s7ok4uw	94	15	therefore	therefore	RB
cord-001835-0s7ok4uw	94	16	strongly	strongly	RB
cord-001835-0s7ok4uw	94	17	dependent	dependent	JJ
cord-001835-0s7ok4uw	94	18	on	on	IN
cord-001835-0s7ok4uw	94	19	the	the	DT
cord-001835-0s7ok4uw	94	20	free	free	JJ
cord-001835-0s7ok4uw	94	21	energy	energy	NN
cord-001835-0s7ok4uw	94	22	of	of	IN
cord-001835-0s7ok4uw	94	23	proton	proton	NN
cord-001835-0s7ok4uw	94	24	solvation	solvation	NN
cord-001835-0s7ok4uw	94	25	.	.	.
cord-001835-0s7ok4uw	95	1	Such	such	JJ
cord-001835-0s7ok4uw	95	2	energy	energy	NN
cord-001835-0s7ok4uw	95	3	is	be	VBZ
cord-001835-0s7ok4uw	95	4	then	then	RB
cord-001835-0s7ok4uw	95	5	determined	determine	VBN
cord-001835-0s7ok4uw	95	6	in	in	IN
cord-001835-0s7ok4uw	95	7	acetonitrile	acetonitrile	NN
cord-001835-0s7ok4uw	95	8	(	(	-LRB-
cord-001835-0s7ok4uw	95	9	ACN	ACN	NNP
cord-001835-0s7ok4uw	95	10	)	)	-RRB-
cord-001835-0s7ok4uw	95	11	,	,	,
cord-001835-0s7ok4uw	95	12	methanol	methanol	NN
cord-001835-0s7ok4uw	95	13	(	(	-LRB-
cord-001835-0s7ok4uw	95	14	MET	MET	NNP
cord-001835-0s7ok4uw	95	15	)	)	-RRB-
cord-001835-0s7ok4uw	95	16	,	,	,
cord-001835-0s7ok4uw	95	17	water	water	NN
cord-001835-0s7ok4uw	95	18	and	and	CC
cord-001835-0s7ok4uw	95	19	dimethyl	dimethyl	NN
cord-001835-0s7ok4uw	95	20	sulfoxide	sulfoxide	NN
cord-001835-0s7ok4uw	95	21	(	(	-LRB-
cord-001835-0s7ok4uw	95	22	DMSO	DMSO	NNP
cord-001835-0s7ok4uw	95	23	)	)	-RRB-
cord-001835-0s7ok4uw	95	24	in	in	IN
cord-001835-0s7ok4uw	95	25	order	order	NN
cord-001835-0s7ok4uw	95	26	to	to	TO
cord-001835-0s7ok4uw	95	27	obtain	obtain	VB
cord-001835-0s7ok4uw	95	28	the	the	DT
cord-001835-0s7ok4uw	95	29	best	good	JJS
cord-001835-0s7ok4uw	95	30	possible	possible	JJ
cord-001835-0s7ok4uw	95	31	match	match	NN
cord-001835-0s7ok4uw	95	32	between	between	IN
cord-001835-0s7ok4uw	95	33	measured	measure	VBN
cord-001835-0s7ok4uw	95	34	and	and	CC
cord-001835-0s7ok4uw	95	35	computed	compute	VBN
cord-001835-0s7ok4uw	95	36	pKa	pKa	NNP
cord-001835-0s7ok4uw	95	37	values	value	NNS
cord-001835-0s7ok4uw	95	38	.	.	.
cord-001835-0s7ok4uw	96	1	The	the	DT
cord-001835-0s7ok4uw	96	2	computation	computation	NN
cord-001835-0s7ok4uw	96	3	of	of	IN
cord-001835-0s7ok4uw	96	4	these	these	DT
cord-001835-0s7ok4uw	96	5	values	value	NNS
cord-001835-0s7ok4uw	96	6	is	be	VBZ
cord-001835-0s7ok4uw	96	7	based	base	VBN
cord-001835-0s7ok4uw	96	8	on	on	IN
cord-001835-0s7ok4uw	96	9	a	a	DT
cord-001835-0s7ok4uw	96	10	combination	combination	NN
cord-001835-0s7ok4uw	96	11	of	of	IN
cord-001835-0s7ok4uw	96	12	quantum	quantum	NN
cord-001835-0s7ok4uw	96	13	chemical	chemical	NN
cord-001835-0s7ok4uw	96	14	(	(	-LRB-
cord-001835-0s7ok4uw	96	15	QC	QC	NNP
cord-001835-0s7ok4uw	96	16	)	)	-RRB-
cord-001835-0s7ok4uw	96	17	and	and	CC
cord-001835-0s7ok4uw	96	18	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	96	19	approaches	approach	NNS
cord-001835-0s7ok4uw	96	20	by	by	IN
cord-001835-0s7ok4uw	96	21	using	use	VBG
cord-001835-0s7ok4uw	96	22	a	a	DT
cord-001835-0s7ok4uw	96	23	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	96	24	cycle	cycle	NN
cord-001835-0s7ok4uw	96	25	connecting	connect	VBG
cord-001835-0s7ok4uw	96	26	gas	gas	NN
cord-001835-0s7ok4uw	96	27	-	-	HYPH
cord-001835-0s7ok4uw	96	28	phase	phase	NN
cord-001835-0s7ok4uw	96	29	and	and	CC
cord-001835-0s7ok4uw	96	30	solvent	solvent	NN
cord-001835-0s7ok4uw	96	31	-	-	HYPH
cord-001835-0s7ok4uw	96	32	phase	phase	NN
cord-001835-0s7ok4uw	96	33	of	of	IN
cord-001835-0s7ok4uw	96	34	proton	proton	NN
cord-001835-0s7ok4uw	96	35	dissociation	dissociation	NN
cord-001835-0s7ok4uw	96	36	.	.	.
cord-001835-0s7ok4uw	97	1	The	the	DT
cord-001835-0s7ok4uw	97	2	computed	compute	VBN
cord-001835-0s7ok4uw	97	3	proton	proton	NN
cord-001835-0s7ok4uw	97	4	solvation	solvation	NN
cord-001835-0s7ok4uw	97	5	energies	energy	NNS
cord-001835-0s7ok4uw	97	6	in	in	IN
cord-001835-0s7ok4uw	97	7	ACN	ACN	NNP
cord-001835-0s7ok4uw	97	8	,	,	,
cord-001835-0s7ok4uw	97	9	MET	MET	NNP
cord-001835-0s7ok4uw	97	10	,	,	,
cord-001835-0s7ok4uw	97	11	water	water	NN
cord-001835-0s7ok4uw	97	12	and	and	CC
cord-001835-0s7ok4uw	97	13	DMSO	dmso	NN
cord-001835-0s7ok4uw	97	14	of	of	IN
cord-001835-0s7ok4uw	97	15	the	the	DT
cord-001835-0s7ok4uw	97	16	present	present	JJ
cord-001835-0s7ok4uw	97	17	study	study	NN
cord-001835-0s7ok4uw	97	18	are	be	VBP
cord-001835-0s7ok4uw	97	19	very	very	RB
cord-001835-0s7ok4uw	97	20	precise	precise	JJ
cord-001835-0s7ok4uw	98	1	(	(	-LRB-
cord-001835-0s7ok4uw	98	2	RMSD	RMSD	NNP
cord-001835-0s7ok4uw	98	3	much	much	RB
cord-001835-0s7ok4uw	98	4	lower	low	JJR
cord-001835-0s7ok4uw	98	5	than	than	IN
cord-001835-0s7ok4uw	98	6	1	1	CD
cord-001835-0s7ok4uw	98	7	pH	ph	NN
cord-001835-0s7ok4uw	98	8	value	value	NN
cord-001835-0s7ok4uw	98	9	)	)	-RRB-
cord-001835-0s7ok4uw	98	10	.	.	.
cord-001835-0s7ok4uw	99	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	99	2	will	will	MD
cord-001835-0s7ok4uw	99	3	be	be	VB
cord-001835-0s7ok4uw	99	4	a	a	DT
cord-001835-0s7ok4uw	99	5	basis	basis	NN
cord-001835-0s7ok4uw	99	6	for	for	IN
cord-001835-0s7ok4uw	99	7	better	well	JJR
cord-001835-0s7ok4uw	99	8	understanding	understanding	NN
cord-001835-0s7ok4uw	99	9	of	of	IN
cord-001835-0s7ok4uw	99	10	proton	proton	NN
cord-001835-0s7ok4uw	99	11	solvation	solvation	NN
cord-001835-0s7ok4uw	99	12	and	and	CC
cord-001835-0s7ok4uw	99	13	help	help	NN
cord-001835-0s7ok4uw	99	14	to	to	TO
cord-001835-0s7ok4uw	99	15	predict	predict	VB
cord-001835-0s7ok4uw	99	16	pKa	pKa	NNP
cord-001835-0s7ok4uw	99	17	values	value	NNS
cord-001835-0s7ok4uw	99	18	of	of	IN
cord-001835-0s7ok4uw	99	19	organic	organic	JJ
cord-001835-0s7ok4uw	99	20	compounds	compound	NNS
cord-001835-0s7ok4uw	99	21	in	in	IN
cord-001835-0s7ok4uw	99	22	different	different	JJ
cord-001835-0s7ok4uw	99	23	solvents	solvent	NNS
cord-001835-0s7ok4uw	99	24	more	more	RBR
cord-001835-0s7ok4uw	99	25	precise	precise	JJ
cord-001835-0s7ok4uw	99	26	.	.	.
cord-001835-0s7ok4uw	100	1	Biochemical	biochemical	JJ
cord-001835-0s7ok4uw	100	2	characterization	characterization	NN
cord-001835-0s7ok4uw	100	3	of	of	IN
cord-001835-0s7ok4uw	100	4	two	two	CD
cord-001835-0s7ok4uw	100	5	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	100	6	distant	distant	JJ
cord-001835-0s7ok4uw	100	7	ten	ten	CD
cord-001835-0s7ok4uw	100	8	-	-	HYPH
cord-001835-0s7ok4uw	100	9	eleven	eleven	CD
cord-001835-0s7ok4uw	100	10	translocation	translocation	NN
cord-001835-0s7ok4uw	100	11	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	100	12	and	and	CC
cord-001835-0s7ok4uw	100	13	their	-PRON-	PRP$
cord-001835-0s7ok4uw	100	14	utility	utility	NN
cord-001835-0s7ok4uw	100	15	in	in	IN
cord-001835-0s7ok4uw	100	16	5-methylcytosine	5-methylcytosine	CD
cord-001835-0s7ok4uw	100	17	sequencing	sequencing	NN
cord-001835-0s7ok4uw	100	18	in	in	IN
cord-001835-0s7ok4uw	100	19	the	the	DT
cord-001835-0s7ok4uw	100	20	genomes	genome	NNS
cord-001835-0s7ok4uw	100	21	at	at	IN
cord-001835-0s7ok4uw	100	22	single	single	JJ
cord-001835-0s7ok4uw	100	23	-	-	HYPH
cord-001835-0s7ok4uw	100	24	base	base	NN
cord-001835-0s7ok4uw	100	25	resolution	resolution	NN
cord-001835-0s7ok4uw	100	26	subtypes	subtype	NNS
cord-001835-0s7ok4uw	100	27	leading	lead	VBG
cord-001835-0s7ok4uw	100	28	to	to	IN
cord-001835-0s7ok4uw	100	29	an	an	DT
cord-001835-0s7ok4uw	100	30	inability	inability	NN
cord-001835-0s7ok4uw	100	31	to	to	TO
cord-001835-0s7ok4uw	100	32	perceive	perceive	VB
cord-001835-0s7ok4uw	100	33	pain	pain	NN
cord-001835-0s7ok4uw	100	34	and	and	CC
cord-001835-0s7ok4uw	100	35	painful	painful	JJ
cord-001835-0s7ok4uw	100	36	neuropathies	neuropathy	NNS
cord-001835-0s7ok4uw	100	37	,	,	,
cord-001835-0s7ok4uw	100	38	respectively	respectively	RB
cord-001835-0s7ok4uw	100	39	.	.	.
cord-001835-0s7ok4uw	101	1	However	however	RB
cord-001835-0s7ok4uw	101	2	,	,	,
cord-001835-0s7ok4uw	101	3	as	as	IN
cord-001835-0s7ok4uw	101	4	NaV	nav	NN
cord-001835-0s7ok4uw	101	5	ion	ion	NN
cord-001835-0s7ok4uw	101	6	channels	channel	NNS
cord-001835-0s7ok4uw	101	7	are	be	VBP
cord-001835-0s7ok4uw	101	8	intimately	intimately	RB
cord-001835-0s7ok4uw	101	9	involved	involved	JJ
cord-001835-0s7ok4uw	101	10	in	in	IN
cord-001835-0s7ok4uw	101	11	almost	almost	RB
cord-001835-0s7ok4uw	101	12	all	all	DT
cord-001835-0s7ok4uw	101	13	aspects	aspect	NNS
cord-001835-0s7ok4uw	101	14	of	of	IN
cord-001835-0s7ok4uw	101	15	physiology	physiology	NN
cord-001835-0s7ok4uw	101	16	,	,	,
cord-001835-0s7ok4uw	101	17	only	only	RB
cord-001835-0s7ok4uw	101	18	the	the	DT
cord-001835-0s7ok4uw	101	19	most	most	RBS
cord-001835-0s7ok4uw	101	20	selective	selective	JJ
cord-001835-0s7ok4uw	101	21	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	101	22	would	would	MD
cord-001835-0s7ok4uw	101	23	be	be	VB
cord-001835-0s7ok4uw	101	24	suitable	suitable	JJ
cord-001835-0s7ok4uw	101	25	as	as	IN
cord-001835-0s7ok4uw	101	26	drug	drug	NN
cord-001835-0s7ok4uw	101	27	leads	lead	NNS
cord-001835-0s7ok4uw	101	28	.	.	.
cord-001835-0s7ok4uw	102	1	Disulfide	disulfide	JJ
cord-001835-0s7ok4uw	102	2	-	-	HYPH
cord-001835-0s7ok4uw	102	3	rich	rich	JJ
cord-001835-0s7ok4uw	102	4	venom	venom	NN
cord-001835-0s7ok4uw	102	5	derived	derive	VBN
cord-001835-0s7ok4uw	102	6	mini	mini	NN
cord-001835-0s7ok4uw	102	7	-	-	NNS
cord-001835-0s7ok4uw	102	8	proteins	protein	NNS
cord-001835-0s7ok4uw	102	9	from	from	IN
cord-001835-0s7ok4uw	102	10	cone	cone	NN
cord-001835-0s7ok4uw	102	11	snails	snail	NNS
cord-001835-0s7ok4uw	102	12	and	and	CC
cord-001835-0s7ok4uw	102	13	spiders	spider	NNS
cord-001835-0s7ok4uw	102	14	are	be	VBP
cord-001835-0s7ok4uw	102	15	being	be	VBG
cord-001835-0s7ok4uw	102	16	actively	actively	RB
cord-001835-0s7ok4uw	102	17	pursued	pursue	VBN
cord-001835-0s7ok4uw	102	18	as	as	IN
cord-001835-0s7ok4uw	102	19	novel	novel	JJ
cord-001835-0s7ok4uw	102	20	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	102	21	for	for	IN
cord-001835-0s7ok4uw	102	22	pain	pain	NN
cord-001835-0s7ok4uw	102	23	,	,	,
cord-001835-0s7ok4uw	102	24	because	because	IN
cord-001835-0s7ok4uw	102	25	of	of	IN
cord-001835-0s7ok4uw	102	26	their	-PRON-	PRP$
cord-001835-0s7ok4uw	102	27	high	high	JJ
cord-001835-0s7ok4uw	102	28	selectivity	selectivity	NN
cord-001835-0s7ok4uw	102	29	and	and	CC
cord-001835-0s7ok4uw	102	30	potency	potency	NN
cord-001835-0s7ok4uw	102	31	at	at	IN
cord-001835-0s7ok4uw	102	32	human	human	JJ
cord-001835-0s7ok4uw	102	33	ion	ion	NN
cord-001835-0s7ok4uw	102	34	channels	channel	NNS
cord-001835-0s7ok4uw	102	35	,	,	,
cord-001835-0s7ok4uw	102	36	including	include	VBG
cord-001835-0s7ok4uw	102	37	sodium	sodium	NN
cord-001835-0s7ok4uw	102	38	channels	channel	NNS
cord-001835-0s7ok4uw	102	39	(	(	-LRB-
cord-001835-0s7ok4uw	102	40	NaV	NaV	NNP
cord-001835-0s7ok4uw	102	41	)	)	-RRB-
cord-001835-0s7ok4uw	102	42	.	.	.
cord-001835-0s7ok4uw	103	1	Two	two	CD
cord-001835-0s7ok4uw	103	2	main	main	JJ
cord-001835-0s7ok4uw	103	3	strategies	strategy	NNS
cord-001835-0s7ok4uw	103	4	of	of	IN
cord-001835-0s7ok4uw	103	5	inhibition	inhibition	NN
cord-001835-0s7ok4uw	103	6	have	have	VBP
cord-001835-0s7ok4uw	103	7	been	be	VBN
cord-001835-0s7ok4uw	103	8	identified	identify	VBN
cord-001835-0s7ok4uw	103	9	;	;	:
cord-001835-0s7ok4uw	103	10	blocking	block	VBG
cord-001835-0s7ok4uw	103	11	the	the	DT
cord-001835-0s7ok4uw	103	12	pore	pore	NN
cord-001835-0s7ok4uw	103	13	and	and	CC
cord-001835-0s7ok4uw	103	14	interacting	interact	VBG
cord-001835-0s7ok4uw	103	15	with	with	IN
cord-001835-0s7ok4uw	103	16	the	the	DT
cord-001835-0s7ok4uw	103	17	voltage	voltage	NN
cord-001835-0s7ok4uw	103	18	-	-	HYPH
cord-001835-0s7ok4uw	103	19	sensor	sensor	NN
cord-001835-0s7ok4uw	103	20	domains	domain	NNS
cord-001835-0s7ok4uw	103	21	(	(	-LRB-
cord-001835-0s7ok4uw	103	22	VSD	VSD	NNP
cord-001835-0s7ok4uw	103	23	)	)	-RRB-
cord-001835-0s7ok4uw	103	24	surrounding	surround	VBG
cord-001835-0s7ok4uw	103	25	the	the	DT
cord-001835-0s7ok4uw	103	26	pore	pore	NN
cord-001835-0s7ok4uw	103	27	.	.	.
cord-001835-0s7ok4uw	104	1	The	the	DT
cord-001835-0s7ok4uw	104	2	ion	ion	NN
cord-001835-0s7ok4uw	104	3	-	-	HYPH
cord-001835-0s7ok4uw	104	4	conducting	conduct	VBG
cord-001835-0s7ok4uw	104	5	pore	pore	NN
cord-001835-0s7ok4uw	104	6	is	be	VBZ
cord-001835-0s7ok4uw	104	7	highly	highly	RB
cord-001835-0s7ok4uw	104	8	conserved	conserve	VBN
cord-001835-0s7ok4uw	104	9	between	between	IN
cord-001835-0s7ok4uw	104	10	all	all	DT
cord-001835-0s7ok4uw	104	11	sodium	sodium	NN
cord-001835-0s7ok4uw	104	12	channel	channel	NN
cord-001835-0s7ok4uw	104	13	subtypes	subtype	NNS
cord-001835-0s7ok4uw	104	14	whereas	whereas	IN
cord-001835-0s7ok4uw	104	15	the	the	DT
cord-001835-0s7ok4uw	104	16	voltage	voltage	NN
cord-001835-0s7ok4uw	104	17	-	-	HYPH
cord-001835-0s7ok4uw	104	18	sensor	sensor	NN
cord-001835-0s7ok4uw	104	19	domain	domain	NN
cord-001835-0s7ok4uw	104	20	binding	bind	VBG
cord-001835-0s7ok4uw	104	21	sites	site	NNS
cord-001835-0s7ok4uw	104	22	are	be	VBP
cord-001835-0s7ok4uw	104	23	less	less	RBR
cord-001835-0s7ok4uw	104	24	conserved	conserve	VBN
cord-001835-0s7ok4uw	104	25	.	.	.
cord-001835-0s7ok4uw	105	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	105	2	,	,	,
cord-001835-0s7ok4uw	105	3	inhibition	inhibition	NN
cord-001835-0s7ok4uw	105	4	of	of	IN
cord-001835-0s7ok4uw	105	5	a	a	DT
cord-001835-0s7ok4uw	105	6	specific	specific	JJ
cord-001835-0s7ok4uw	105	7	NaV	nav	NN
cord-001835-0s7ok4uw	105	8	isoform	isoform	NN
cord-001835-0s7ok4uw	105	9	is	be	VBZ
cord-001835-0s7ok4uw	105	10	more	more	RBR
cord-001835-0s7ok4uw	105	11	achievable	achievable	JJ
cord-001835-0s7ok4uw	105	12	using	use	VBG
cord-001835-0s7ok4uw	105	13	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	105	14	that	that	WDT
cord-001835-0s7ok4uw	105	15	modulate	modulate	VBP
cord-001835-0s7ok4uw	105	16	VSDs	vsd	NNS
cord-001835-0s7ok4uw	105	17	than	than	IN
cord-001835-0s7ok4uw	105	18	with	with	IN
cord-001835-0s7ok4uw	105	19	pore	pore	NN
cord-001835-0s7ok4uw	105	20	blockers	blocker	NNS
cord-001835-0s7ok4uw	105	21	.	.	.
cord-001835-0s7ok4uw	106	1	Gating	gate	VBG
cord-001835-0s7ok4uw	106	2	modifier	modifier	NN
cord-001835-0s7ok4uw	106	3	toxins	toxin	NNS
cord-001835-0s7ok4uw	106	4	from	from	IN
cord-001835-0s7ok4uw	106	5	spider	spider	NN
cord-001835-0s7ok4uw	106	6	and	and	CC
cord-001835-0s7ok4uw	106	7	cone	cone	NN
cord-001835-0s7ok4uw	106	8	snail	snail	NN
cord-001835-0s7ok4uw	106	9	venom	venom	NN
cord-001835-0s7ok4uw	106	10	inhibit	inhibit	VBP
cord-001835-0s7ok4uw	106	11	NaV1.7	NaV1.7	NNS
cord-001835-0s7ok4uw	106	12	and	and	CC
cord-001835-0s7ok4uw	106	13	NaV1.8	NaV1.8	VBN
cord-001835-0s7ok4uw	106	14	by	by	IN
cord-001835-0s7ok4uw	106	15	interacting	interact	VBG
cord-001835-0s7ok4uw	106	16	with	with	IN
cord-001835-0s7ok4uw	106	17	the	the	DT
cord-001835-0s7ok4uw	106	18	VSD	VSD	NNP
cord-001835-0s7ok4uw	106	19	.	.	.
cord-001835-0s7ok4uw	107	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	107	2	appear	appear	VBP
cord-001835-0s7ok4uw	107	3	to	to	TO
cord-001835-0s7ok4uw	107	4	reach	reach	VB
cord-001835-0s7ok4uw	107	5	their	-PRON-	PRP$
cord-001835-0s7ok4uw	107	6	target	target	NN
cord-001835-0s7ok4uw	107	7	by	by	IN
cord-001835-0s7ok4uw	107	8	partitioning	partition	VBG
cord-001835-0s7ok4uw	107	9	into	into	IN
cord-001835-0s7ok4uw	107	10	the	the	DT
cord-001835-0s7ok4uw	107	11	lipid	lipid	NN
cord-001835-0s7ok4uw	107	12	membrane	membrane	NN
cord-001835-0s7ok4uw	107	13	surrounding	surround	VBG
cord-001835-0s7ok4uw	107	14	the	the	DT
cord-001835-0s7ok4uw	107	15	ion	ion	NN
cord-001835-0s7ok4uw	107	16	channel	channel	NN
cord-001835-0s7ok4uw	107	17	,	,	,
cord-001835-0s7ok4uw	107	18	thus	thus	RB
cord-001835-0s7ok4uw	107	19	enabling	enable	VBG
cord-001835-0s7ok4uw	107	20	access	access	NN
cord-001835-0s7ok4uw	107	21	to	to	IN
cord-001835-0s7ok4uw	107	22	the	the	DT
cord-001835-0s7ok4uw	107	23	VSD	VSD	NNP
cord-001835-0s7ok4uw	107	24	.	.	.
cord-001835-0s7ok4uw	108	1	Toxin	toxin	NN
cord-001835-0s7ok4uw	108	2	pharmacology	pharmacology	NN
cord-001835-0s7ok4uw	108	3	may	may	MD
cord-001835-0s7ok4uw	108	4	therefore	therefore	RB
cord-001835-0s7ok4uw	108	5	not	not	RB
cord-001835-0s7ok4uw	108	6	only	only	RB
cord-001835-0s7ok4uw	108	7	be	be	VB
cord-001835-0s7ok4uw	108	8	driven	drive	VBN
cord-001835-0s7ok4uw	108	9	by	by	IN
cord-001835-0s7ok4uw	108	10	the	the	DT
cord-001835-0s7ok4uw	108	11	peptide	peptide	NN
cord-001835-0s7ok4uw	108	12	-	-	HYPH
cord-001835-0s7ok4uw	108	13	ion	ion	NN
cord-001835-0s7ok4uw	108	14	channel	channel	NN
cord-001835-0s7ok4uw	108	15	interactions	interaction	NNS
cord-001835-0s7ok4uw	108	16	,	,	,
cord-001835-0s7ok4uw	108	17	but	but	CC
cord-001835-0s7ok4uw	108	18	also	also	RB
cord-001835-0s7ok4uw	108	19	including	include	VBG
cord-001835-0s7ok4uw	108	20	the	the	DT
cord-001835-0s7ok4uw	108	21	lipids	lipid	NNS
cord-001835-0s7ok4uw	108	22	surrounding	surround	VBG
cord-001835-0s7ok4uw	108	23	the	the	DT
cord-001835-0s7ok4uw	108	24	channel	channel	NN
cord-001835-0s7ok4uw	108	25	protein	protein	NN
cord-001835-0s7ok4uw	108	26	,	,	,
cord-001835-0s7ok4uw	108	27	a	a	DT
cord-001835-0s7ok4uw	108	28	feature	feature	NN
cord-001835-0s7ok4uw	108	29	that	that	WDT
cord-001835-0s7ok4uw	108	30	is	be	VBZ
cord-001835-0s7ok4uw	108	31	very	very	RB
cord-001835-0s7ok4uw	108	32	much	much	RB
cord-001835-0s7ok4uw	108	33	under	under	IN
cord-001835-0s7ok4uw	108	34	explored	explore	VBN
cord-001835-0s7ok4uw	108	35	.	.	.
cord-001835-0s7ok4uw	109	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	109	2	is	be	VBZ
cord-001835-0s7ok4uw	109	3	therefore	therefore	RB
cord-001835-0s7ok4uw	109	4	apparent	apparent	JJ
cord-001835-0s7ok4uw	109	5	that	that	IN
cord-001835-0s7ok4uw	109	6	peptide	peptide	NN
cord-001835-0s7ok4uw	109	7	-	-	HYPH
cord-001835-0s7ok4uw	109	8	lipid	lipid	NN
cord-001835-0s7ok4uw	109	9	interactions	interaction	NNS
cord-001835-0s7ok4uw	109	10	in	in	IN
cord-001835-0s7ok4uw	109	11	combination	combination	NN
cord-001835-0s7ok4uw	109	12	with	with	IN
cord-001835-0s7ok4uw	109	13	peptide	peptide	NN
cord-001835-0s7ok4uw	109	14	-	-	HYPH
cord-001835-0s7ok4uw	109	15	channel	channel	NN
cord-001835-0s7ok4uw	109	16	interactions	interaction	NNS
cord-001835-0s7ok4uw	109	17	need	need	VBP
cord-001835-0s7ok4uw	109	18	to	to	TO
cord-001835-0s7ok4uw	109	19	be	be	VB
cord-001835-0s7ok4uw	109	20	considered	consider	VBN
cord-001835-0s7ok4uw	109	21	when	when	WRB
cord-001835-0s7ok4uw	109	22	designing	design	VBG
cord-001835-0s7ok4uw	109	23	potent	potent	JJ
cord-001835-0s7ok4uw	109	24	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	109	25	.	.	.
cord-001835-0s7ok4uw	110	1	Using	use	VBG
cord-001835-0s7ok4uw	110	2	a	a	DT
cord-001835-0s7ok4uw	110	3	range	range	NN
cord-001835-0s7ok4uw	110	4	of	of	IN
cord-001835-0s7ok4uw	110	5	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	110	6	techniques	technique	NNS
cord-001835-0s7ok4uw	110	7	,	,	,
cord-001835-0s7ok4uw	110	8	including	include	VBG
cord-001835-0s7ok4uw	110	9	surface	surface	NN
cord-001835-0s7ok4uw	110	10	plasmon	plasmon	JJ
cord-001835-0s7ok4uw	110	11	resonance	resonance	NN
cord-001835-0s7ok4uw	110	12	and	and	CC
cord-001835-0s7ok4uw	110	13	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	110	14	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	110	15	resonance	resonance	NN
cord-001835-0s7ok4uw	110	16	,	,	,
cord-001835-0s7ok4uw	110	17	we	-PRON-	PRP
cord-001835-0s7ok4uw	110	18	are	be	VBP
cord-001835-0s7ok4uw	110	19	studying	study	VBG
cord-001835-0s7ok4uw	110	20	the	the	DT
cord-001835-0s7ok4uw	110	21	interactions	interaction	NNS
cord-001835-0s7ok4uw	110	22	underpinning	underpin	VBG
cord-001835-0s7ok4uw	110	23	the	the	DT
cord-001835-0s7ok4uw	110	24	mechanism	mechanism	NN
cord-001835-0s7ok4uw	110	25	of	of	IN
cord-001835-0s7ok4uw	110	26	action	action	NN
cord-001835-0s7ok4uw	110	27	between	between	IN
cord-001835-0s7ok4uw	110	28	toxins	toxin	NNS
cord-001835-0s7ok4uw	110	29	and	and	CC
cord-001835-0s7ok4uw	110	30	membranes	membrane	NNS
cord-001835-0s7ok4uw	110	31	and	and	CC
cord-001835-0s7ok4uw	110	32	toxins	toxin	NNS
cord-001835-0s7ok4uw	110	33	and	and	CC
cord-001835-0s7ok4uw	110	34	ion	ion	NN
cord-001835-0s7ok4uw	110	35	channels	channel	NNS
cord-001835-0s7ok4uw	110	36	.	.	.
cord-001835-0s7ok4uw	111	1	Initial	initial	JJ
cord-001835-0s7ok4uw	111	2	results	result	NNS
cord-001835-0s7ok4uw	111	3	show	show	VBP
cord-001835-0s7ok4uw	111	4	that	that	IN
cord-001835-0s7ok4uw	111	5	the	the	DT
cord-001835-0s7ok4uw	111	6	lipid	lipid	NN
cord-001835-0s7ok4uw	111	7	composition	composition	NN
cord-001835-0s7ok4uw	111	8	surrounding	surround	VBG
cord-001835-0s7ok4uw	111	9	ion	ion	NN
cord-001835-0s7ok4uw	111	10	channels	channel	NNS
cord-001835-0s7ok4uw	111	11	play	play	VBP
cord-001835-0s7ok4uw	111	12	a	a	DT
cord-001835-0s7ok4uw	111	13	major	major	JJ
cord-001835-0s7ok4uw	111	14	role	role	NN
cord-001835-0s7ok4uw	111	15	in	in	IN
cord-001835-0s7ok4uw	111	16	terms	term	NNS
cord-001835-0s7ok4uw	111	17	of	of	IN
cord-001835-0s7ok4uw	111	18	toxin	toxin	NN
cord-001835-0s7ok4uw	111	19	:	:	:
cord-001835-0s7ok4uw	111	20	lipid	lipid	NN
cord-001835-0s7ok4uw	111	21	interaction	interaction	NN
cord-001835-0s7ok4uw	111	22	and	and	CC
cord-001835-0s7ok4uw	111	23	that	that	IN
cord-001835-0s7ok4uw	111	24	these	these	DT
cord-001835-0s7ok4uw	111	25	interactions	interaction	NNS
cord-001835-0s7ok4uw	111	26	can	can	MD
cord-001835-0s7ok4uw	111	27	be	be	VB
cord-001835-0s7ok4uw	111	28	used	use	VBN
cord-001835-0s7ok4uw	111	29	in	in	IN
cord-001835-0s7ok4uw	111	30	combination	combination	NN
cord-001835-0s7ok4uw	111	31	with	with	IN
cord-001835-0s7ok4uw	111	32	traditional	traditional	JJ
cord-001835-0s7ok4uw	111	33	structure	structure	NN
cord-001835-0s7ok4uw	111	34	-	-	HYPH
cord-001835-0s7ok4uw	111	35	activity	activity	NN
cord-001835-0s7ok4uw	111	36	relationship	relationship	NN
cord-001835-0s7ok4uw	111	37	studies	study	NNS
cord-001835-0s7ok4uw	111	38	to	to	TO
cord-001835-0s7ok4uw	111	39	design	design	VB
cord-001835-0s7ok4uw	111	40	selective	selective	JJ
cord-001835-0s7ok4uw	111	41	and	and	CC
cord-001835-0s7ok4uw	111	42	potent	potent	JJ
cord-001835-0s7ok4uw	111	43	NaV	nav	NN
cord-001835-0s7ok4uw	111	44	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	111	45	,	,	,
cord-001835-0s7ok4uw	111	46	which	which	WDT
cord-001835-0s7ok4uw	111	47	will	will	MD
cord-001835-0s7ok4uw	111	48	be	be	VB
cord-001835-0s7ok4uw	111	49	discussed	discuss	VBN
cord-001835-0s7ok4uw	111	50	.	.	.
cord-001835-0s7ok4uw	112	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	112	2	believe	believe	VBP
cord-001835-0s7ok4uw	112	3	that	that	IN
cord-001835-0s7ok4uw	112	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	112	5	studies	study	NNS
cord-001835-0s7ok4uw	112	6	will	will	MD
cord-001835-0s7ok4uw	112	7	ultimately	ultimately	RB
cord-001835-0s7ok4uw	112	8	delineate	delineate	VB
cord-001835-0s7ok4uw	112	9	what	what	WP
cord-001835-0s7ok4uw	112	10	drives	drive	NNS
cord-001835-0s7ok4uw	112	11	toxin	toxin	NN
cord-001835-0s7ok4uw	112	12	pharmacology	pharmacology	NN
cord-001835-0s7ok4uw	112	13	and	and	CC
cord-001835-0s7ok4uw	112	14	NaV	nav	NN
cord-001835-0s7ok4uw	112	15	subtype	subtype	NN
cord-001835-0s7ok4uw	112	16	selectivity	selectivity	NN
cord-001835-0s7ok4uw	112	17	and	and	CC
cord-001835-0s7ok4uw	112	18	will	will	MD
cord-001835-0s7ok4uw	112	19	lead	lead	VB
cord-001835-0s7ok4uw	112	20	to	to	TO
cord-001835-0s7ok4uw	112	21	improve	improve	VB
cord-001835-0s7ok4uw	112	22	rationally	rationally	RB
cord-001835-0s7ok4uw	112	23	engineering	engineering	NN
cord-001835-0s7ok4uw	112	24	of	of	IN
cord-001835-0s7ok4uw	112	25	novel	novel	JJ
cord-001835-0s7ok4uw	112	26	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	112	27	for	for	IN
cord-001835-0s7ok4uw	112	28	the	the	DT
cord-001835-0s7ok4uw	112	29	treatment	treatment	NN
cord-001835-0s7ok4uw	112	30	of	of	IN
cord-001835-0s7ok4uw	112	31	pain	pain	NN
cord-001835-0s7ok4uw	112	32	.	.	.
cord-001835-0s7ok4uw	113	1	Micelles	micelle	NNS
cord-001835-0s7ok4uw	113	2	promote	promote	VBP
cord-001835-0s7ok4uw	113	3	Aß42	Aß42	NNP
cord-001835-0s7ok4uw	113	4	assembly	assembly	NN
cord-001835-0s7ok4uw	113	5	into	into	IN
cord-001835-0s7ok4uw	113	6	pore	pore	NN
cord-001835-0s7ok4uw	113	7	-	-	HYPH
cord-001835-0s7ok4uw	113	8	forming	form	VBG
cord-001835-0s7ok4uw	113	9	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	113	10	Montserrat	Montserrat	NNP
cord-001835-0s7ok4uw	113	11	Serra	Serra	NNP
cord-001835-0s7ok4uw	113	12	-	-	HYPH
cord-001835-0s7ok4uw	113	13	Batiste	Batiste	NNP
cord-001835-0s7ok4uw	113	14	1	1	CD
cord-001835-0s7ok4uw	113	15	,	,	,
cord-001835-0s7ok4uw	113	16	Mariam	Mariam	NNP
cord-001835-0s7ok4uw	113	17	Bayoumi	Bayoumi	NNP
cord-001835-0s7ok4uw	113	18	2	2	CD
cord-001835-0s7ok4uw	114	1	,	,	,
cord-001835-0s7ok4uw	114	2	Margarida	Margarida	NNP
cord-001835-0s7ok4uw	114	3	Gair	Gair	NNP
cord-001835-0s7ok4uw	114	4	ı	ı	NNP
cord-001835-0s7ok4uw	114	5	3	3	CD
cord-001835-0s7ok4uw	114	6	,	,	,
cord-001835-0s7ok4uw	114	7	Mart	Mart	NNP
cord-001835-0s7ok4uw	114	8	ı	ı	NNP
cord-001835-0s7ok4uw	114	9	Ninot	Ninot	NNP
cord-001835-0s7ok4uw	114	10	-	-	HYPH
cord-001835-0s7ok4uw	114	11	Pedrosa	Pedrosa	NNP
cord-001835-0s7ok4uw	114	12	1	1	CD
cord-001835-0s7ok4uw	114	13	,	,	,
cord-001835-0s7ok4uw	114	14	Giovanni	Giovanni	NNP
cord-001835-0s7ok4uw	114	15	Maglia	Maglia	NNP
cord-001835-0s7ok4uw	114	16	2	2	CD
cord-001835-0s7ok4uw	114	17	,	,	,
cord-001835-0s7ok4uw	114	18	Nat	Nat	NNP
cord-001835-0s7ok4uw	114	19	alia	alia	NNP
cord-001835-0s7ok4uw	114	20	Carulla	Carulla	NNP
cord-001835-0s7ok4uw	115	1	1	1	CD
cord-001835-0s7ok4uw	115	2	1	1	CD
cord-001835-0s7ok4uw	115	3	Institute	Institute	NNP
cord-001835-0s7ok4uw	115	4	for	for	IN
cord-001835-0s7ok4uw	115	5	Research	Research	NNP
cord-001835-0s7ok4uw	115	6	in	in	IN
cord-001835-0s7ok4uw	115	7	Biomedicine	Biomedicine	NNP
cord-001835-0s7ok4uw	115	8	(	(	-LRB-
cord-001835-0s7ok4uw	115	9	IRB	IRB	NNP
cord-001835-0s7ok4uw	115	10	Barcelona	Barcelona	NNP
cord-001835-0s7ok4uw	115	11	)	)	-RRB-
cord-001835-0s7ok4uw	115	12	,	,	,
cord-001835-0s7ok4uw	115	13	2	2	CD
cord-001835-0s7ok4uw	115	14	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	115	15	,	,	,
cord-001835-0s7ok4uw	115	16	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	115	17	and	and	CC
cord-001835-0s7ok4uw	115	18	Structural	Structural	NNP
cord-001835-0s7ok4uw	115	19	Biology	Biology	NNP
cord-001835-0s7ok4uw	115	20	Section	Section	NNP
cord-001835-0s7ok4uw	115	21	,	,	,
cord-001835-0s7ok4uw	115	22	University	University	NNP
cord-001835-0s7ok4uw	115	23	of	of	IN
cord-001835-0s7ok4uw	115	24	Leuven	Leuven	NNP
cord-001835-0s7ok4uw	115	25	,	,	,
cord-001835-0s7ok4uw	115	26	3	3	CD
cord-001835-0s7ok4uw	115	27	 	 	_SP
cord-001835-0s7ok4uw	115	28	The	the	DT
cord-001835-0s7ok4uw	115	29	formation	formation	NN
cord-001835-0s7ok4uw	115	30	of	of	IN
cord-001835-0s7ok4uw	115	31	amyloid	amyloid	NN
cord-001835-0s7ok4uw	115	32	-	-	HYPH
cord-001835-0s7ok4uw	115	33	b	b	NN
cord-001835-0s7ok4uw	115	34	peptide	peptide	NN
cord-001835-0s7ok4uw	115	35	(	(	-LRB-
cord-001835-0s7ok4uw	115	36	Ab	ab	NN
cord-001835-0s7ok4uw	115	37	)	)	-RRB-
cord-001835-0s7ok4uw	115	38	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	115	39	at	at	IN
cord-001835-0s7ok4uw	115	40	the	the	DT
cord-001835-0s7ok4uw	115	41	cellular	cellular	JJ
cord-001835-0s7ok4uw	115	42	membrane	membrane	NN
cord-001835-0s7ok4uw	115	43	is	be	VBZ
cord-001835-0s7ok4uw	115	44	considered	consider	VBN
cord-001835-0s7ok4uw	115	45	to	to	TO
cord-001835-0s7ok4uw	115	46	be	be	VB
cord-001835-0s7ok4uw	115	47	a	a	DT
cord-001835-0s7ok4uw	115	48	crucial	crucial	JJ
cord-001835-0s7ok4uw	115	49	process	process	NN
cord-001835-0s7ok4uw	115	50	underlying	underlie	VBG
cord-001835-0s7ok4uw	115	51	neurotoxicity	neurotoxicity	NN
cord-001835-0s7ok4uw	115	52	in	in	IN
cord-001835-0s7ok4uw	115	53	Alzheime	Alzheime	NNP
cord-001835-0s7ok4uw	115	54	rs	rs	NN
cord-001835-0s7ok4uw	115	55	disease	disease	NN
cord-001835-0s7ok4uw	115	56	(	(	-LRB-
cord-001835-0s7ok4uw	115	57	AD	ad	NN
cord-001835-0s7ok4uw	115	58	)	)	-RRB-
cord-001835-0s7ok4uw	115	59	.	.	.
cord-001835-0s7ok4uw	116	1	1	1	LS
cord-001835-0s7ok4uw	116	2	-	-	SYM
cord-001835-0s7ok4uw	116	3	2	2	CD
cord-001835-0s7ok4uw	117	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	117	2	,	,	,
cord-001835-0s7ok4uw	117	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	117	4	is	be	VBZ
cord-001835-0s7ok4uw	117	5	important	important	JJ
cord-001835-0s7ok4uw	117	6	to	to	TO
cord-001835-0s7ok4uw	117	7	understand	understand	VB
cord-001835-0s7ok4uw	117	8	how	how	WRB
cord-001835-0s7ok4uw	117	9	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	117	10	form	form	VBP
cord-001835-0s7ok4uw	117	11	within	within	IN
cord-001835-0s7ok4uw	117	12	a	a	DT
cord-001835-0s7ok4uw	117	13	membrane	membrane	NN
cord-001835-0s7ok4uw	117	14	environment	environment	NN
cord-001835-0s7ok4uw	117	15	.	.	.
cord-001835-0s7ok4uw	118	1	Using	use	VBG
cord-001835-0s7ok4uw	118	2	solution	solution	NN
cord-001835-0s7ok4uw	118	3	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	118	4	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	118	5	resonance	resonance	NN
cord-001835-0s7ok4uw	118	6	(	(	-LRB-
cord-001835-0s7ok4uw	118	7	NMR	NMR	NNP
cord-001835-0s7ok4uw	118	8	)	)	-RRB-
cord-001835-0s7ok4uw	118	9	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	118	10	,	,	,
cord-001835-0s7ok4uw	118	11	combined	combine	VBN
cord-001835-0s7ok4uw	118	12	with	with	IN
cord-001835-0s7ok4uw	118	13	size	size	NN
cord-001835-0s7ok4uw	118	14	exclusion	exclusion	NN
cord-001835-0s7ok4uw	118	15	chromatography	chromatography	NN
cord-001835-0s7ok4uw	118	16	(	(	-LRB-
cord-001835-0s7ok4uw	118	17	SEC	SEC	NNP
cord-001835-0s7ok4uw	118	18	)	)	-RRB-
cord-001835-0s7ok4uw	118	19	,	,	,
cord-001835-0s7ok4uw	118	20	we	-PRON-	PRP
cord-001835-0s7ok4uw	118	21	have	have	VBP
cord-001835-0s7ok4uw	118	22	studied	study	VBN
cord-001835-0s7ok4uw	118	23	the	the	DT
cord-001835-0s7ok4uw	118	24	two	two	CD
cord-001835-0s7ok4uw	118	25	major	major	JJ
cord-001835-0s7ok4uw	118	26	Ab	Ab	NNP
cord-001835-0s7ok4uw	118	27	variants	variant	NNS
cord-001835-0s7ok4uw	118	28	-	-	:
cord-001835-0s7ok4uw	118	29	Ab40	Ab40	NNP
cord-001835-0s7ok4uw	118	30	and	and	CC
cord-001835-0s7ok4uw	118	31	Ab42	Ab42	NNP
cord-001835-0s7ok4uw	118	32	,	,	,
cord-001835-0s7ok4uw	118	33	the	the	DT
cord-001835-0s7ok4uw	118	34	latter	latter	JJ
cord-001835-0s7ok4uw	118	35	having	have	VBG
cord-001835-0s7ok4uw	118	36	a	a	DT
cord-001835-0s7ok4uw	118	37	more	more	RBR
cord-001835-0s7ok4uw	118	38	prominent	prominent	JJ
cord-001835-0s7ok4uw	118	39	role	role	NN
cord-001835-0s7ok4uw	118	40	in	in	IN
cord-001835-0s7ok4uw	118	41	AD	ad	NN
cord-001835-0s7ok4uw	118	42	than	than	IN
cord-001835-0s7ok4uw	118	43	the	the	DT
cord-001835-0s7ok4uw	118	44	former	former	JJ
cord-001835-0s7ok4uw	118	45	-	-	HYPH
cord-001835-0s7ok4uw	118	46	under	under	IN
cord-001835-0s7ok4uw	118	47	carefully	carefully	RB
cord-001835-0s7ok4uw	118	48	selected	select	VBN
cord-001835-0s7ok4uw	118	49	micelle	micelle	NN
cord-001835-0s7ok4uw	118	50	conditions	condition	NNS
cord-001835-0s7ok4uw	118	51	intended	intend	VBN
cord-001835-0s7ok4uw	118	52	to	to	TO
cord-001835-0s7ok4uw	118	53	mimic	mimic	VB
cord-001835-0s7ok4uw	118	54	a	a	DT
cord-001835-0s7ok4uw	118	55	membrane	membrane	NN
cord-001835-0s7ok4uw	118	56	environment	environment	NN
cord-001835-0s7ok4uw	118	57	.	.	.
cord-001835-0s7ok4uw	119	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	119	2	results	result	NNS
cord-001835-0s7ok4uw	119	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	119	4	that	that	IN
cord-001835-0s7ok4uw	119	5	after	after	IN
cord-001835-0s7ok4uw	119	6	an	an	DT
cord-001835-0s7ok4uw	119	7	incubation	incubation	NN
cord-001835-0s7ok4uw	119	8	period	period	NN
cord-001835-0s7ok4uw	119	9	,	,	,
cord-001835-0s7ok4uw	119	10	Ab42	Ab42	NNP
cord-001835-0s7ok4uw	119	11	,	,	,
cord-001835-0s7ok4uw	119	12	but	but	CC
cord-001835-0s7ok4uw	119	13	not	not	RB
cord-001835-0s7ok4uw	119	14	Ab40	Ab40	NNPS
cord-001835-0s7ok4uw	119	15	,	,	,
cord-001835-0s7ok4uw	119	16	assembles	assemble	VBZ
cord-001835-0s7ok4uw	119	17	into	into	IN
cord-001835-0s7ok4uw	119	18	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	119	19	with	with	IN
cord-001835-0s7ok4uw	119	20	specific	specific	JJ
cord-001835-0s7ok4uw	119	21	structural	structural	JJ
cord-001835-0s7ok4uw	119	22	properties	property	NNS
cord-001835-0s7ok4uw	119	23	,	,	,
cord-001835-0s7ok4uw	119	24	which	which	WDT
cord-001835-0s7ok4uw	119	25	we	-PRON-	PRP
cord-001835-0s7ok4uw	119	26	have	have	VBP
cord-001835-0s7ok4uw	119	27	named	name	VBN
cord-001835-0s7ok4uw	119	28	Stabilized	stabilize	VBN
cord-001835-0s7ok4uw	119	29	Micelle	Micelle	NNP
cord-001835-0s7ok4uw	119	30	Oligomers	Oligomers	NNP
cord-001835-0s7ok4uw	119	31	(	(	-LRB-
cord-001835-0s7ok4uw	119	32	SMOs	SMOs	NNP
cord-001835-0s7ok4uw	119	33	)	)	-RRB-
cord-001835-0s7ok4uw	119	34	.	.	.
cord-001835-0s7ok4uw	120	1	SMO	SMO	NNP
cord-001835-0s7ok4uw	120	2	complexes	complex	NNS
cord-001835-0s7ok4uw	120	3	incorporate	incorporate	VBP
cord-001835-0s7ok4uw	120	4	into	into	IN
cord-001835-0s7ok4uw	120	5	lipid	lipid	NN
cord-001835-0s7ok4uw	120	6	bilayers	bilayer	NNS
cord-001835-0s7ok4uw	120	7	as	as	RB
cord-001835-0s7ok4uw	120	8	well	well	RB
cord-001835-0s7ok4uw	120	9	-	-	HYPH
cord-001835-0s7ok4uw	120	10	defined	define	VBN
cord-001835-0s7ok4uw	120	11	pores	pore	NNS
cord-001835-0s7ok4uw	120	12	,	,	,
cord-001835-0s7ok4uw	120	13	a	a	DT
cord-001835-0s7ok4uw	120	14	feature	feature	NN
cord-001835-0s7ok4uw	120	15	linked	link	VBN
cord-001835-0s7ok4uw	120	16	to	to	IN
cord-001835-0s7ok4uw	120	17	neurotoxicity	neurotoxicity	NN
cord-001835-0s7ok4uw	120	18	.	.	.
cord-001835-0s7ok4uw	121	1	These	these	DT
cord-001835-0s7ok4uw	121	2	results	result	NNS
cord-001835-0s7ok4uw	121	3	have	have	VBP
cord-001835-0s7ok4uw	121	4	important	important	JJ
cord-001835-0s7ok4uw	121	5	implications	implication	NNS
cord-001835-0s7ok4uw	121	6	in	in	IN
cord-001835-0s7ok4uw	121	7	the	the	DT
cord-001835-0s7ok4uw	121	8	AD	ad	NN
cord-001835-0s7ok4uw	121	9	field	field	NN
cord-001835-0s7ok4uw	121	10	as	as	IN
cord-001835-0s7ok4uw	121	11	they	-PRON-	PRP
cord-001835-0s7ok4uw	121	12	provide	provide	VBP
cord-001835-0s7ok4uw	121	13	a	a	DT
cord-001835-0s7ok4uw	121	14	new	new	JJ
cord-001835-0s7ok4uw	121	15	perspective	perspective	NN
cord-001835-0s7ok4uw	121	16	on	on	IN
cord-001835-0s7ok4uw	121	17	how	how	WRB
cord-001835-0s7ok4uw	121	18	Ab	Ab	NNP
cord-001835-0s7ok4uw	121	19	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	121	20	cause	cause	VBP
cord-001835-0s7ok4uw	121	21	neurotoxicity	neurotoxicity	NN
cord-001835-0s7ok4uw	121	22	.	.	.
cord-001835-0s7ok4uw	122	1	Indeed	indeed	RB
cord-001835-0s7ok4uw	122	2	,	,	,
cord-001835-0s7ok4uw	122	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	122	4	findings	finding	NNS
cord-001835-0s7ok4uw	122	5	constitute	constitute	VBP
cord-001835-0s7ok4uw	122	6	a	a	DT
cord-001835-0s7ok4uw	122	7	first	first	JJ
cord-001835-0s7ok4uw	122	8	step	step	NN
cord-001835-0s7ok4uw	122	9	towards	towards	IN
cord-001835-0s7ok4uw	122	10	the	the	DT
cord-001835-0s7ok4uw	122	11	establishment	establishment	NN
cord-001835-0s7ok4uw	122	12	of	of	IN
cord-001835-0s7ok4uw	122	13	a	a	DT
cord-001835-0s7ok4uw	122	14	new	new	JJ
cord-001835-0s7ok4uw	122	15	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	122	16	target	target	NN
cord-001835-0s7ok4uw	122	17	for	for	IN
cord-001835-0s7ok4uw	122	18	AD	ad	NN
cord-001835-0s7ok4uw	122	19	.	.	.
cord-001835-0s7ok4uw	123	1	dimer	dimer	NNP
cord-001835-0s7ok4uw	123	2	formation	formation	NN
cord-001835-0s7ok4uw	123	3	.	.	.
cord-001835-0s7ok4uw	124	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	124	2	should	should	MD
cord-001835-0s7ok4uw	124	3	be	be	VB
cord-001835-0s7ok4uw	124	4	noted	note	VBN
cord-001835-0s7ok4uw	124	5	that	that	IN
cord-001835-0s7ok4uw	124	6	this	this	DT
cord-001835-0s7ok4uw	124	7	Nb	Nb	NNP
cord-001835-0s7ok4uw	124	8	peptide	peptide	NN
cord-001835-0s7ok4uw	124	9	contains	contain	VBZ
cord-001835-0s7ok4uw	124	10	the	the	DT
cord-001835-0s7ok4uw	124	11	autophosphorylatable	autophosphorylatable	JJ
cord-001835-0s7ok4uw	124	12	Ser-11	Ser-11	NNP
cord-001835-0s7ok4uw	124	13	associated	associate	VBN
cord-001835-0s7ok4uw	124	14	with	with	IN
cord-001835-0s7ok4uw	124	15	PhK	phk	JJ
cord-001835-0s7ok4uw	124	16	activation	activation	NN
cord-001835-0s7ok4uw	124	17	,	,	,
cord-001835-0s7ok4uw	124	18	and	and	CC
cord-001835-0s7ok4uw	124	19	phosphorylated	phosphorylate	VBD
cord-001835-0s7ok4uw	124	20	Nb	Nb	NNP
cord-001835-0s7ok4uw	124	21	;	;	:
cord-001835-0s7ok4uw	124	22	peptide	peptide	NN
cord-001835-0s7ok4uw	124	23	was	be	VBD
cord-001835-0s7ok4uw	124	24	considerably	considerably	RB
cord-001835-0s7ok4uw	124	25	less	less	RBR
cord-001835-0s7ok4uw	124	26	effective	effective	JJ
cord-001835-0s7ok4uw	124	27	in	in	IN
cord-001835-0s7ok4uw	124	28	promoting	promote	VBG
cord-001835-0s7ok4uw	124	29	b	b	NN
cord-001835-0s7ok4uw	124	30	-	-	HYPH
cord-001835-0s7ok4uw	124	31	dimer	dimer	NN
cord-001835-0s7ok4uw	124	32	formation	formation	NN
cord-001835-0s7ok4uw	124	33	than	than	IN
cord-001835-0s7ok4uw	124	34	non	non	JJ
cord-001835-0s7ok4uw	124	35	-	-	JJ
cord-001835-0s7ok4uw	124	36	phosphorylated	phosphorylated	JJ
cord-001835-0s7ok4uw	124	37	peptide	peptide	NN
cord-001835-0s7ok4uw	124	38	.	.	.
cord-001835-0s7ok4uw	125	1	These	these	DT
cord-001835-0s7ok4uw	125	2	results	result	NNS
cord-001835-0s7ok4uw	125	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	125	4	a	a	DT
cord-001835-0s7ok4uw	125	5	role	role	NN
cord-001835-0s7ok4uw	125	6	for	for	IN
cord-001835-0s7ok4uw	125	7	Ser-11	Ser-11	NNP
cord-001835-0s7ok4uw	125	8	autophosphorylation	autophosphorylation	NN
cord-001835-0s7ok4uw	125	9	in	in	IN
cord-001835-0s7ok4uw	125	10	mediating	mediate	VBG
cord-001835-0s7ok4uw	125	11	homodimeric	homodimeric	NNP
cord-001835-0s7ok4uw	125	12	b	b	NNP
cord-001835-0s7ok4uw	125	13	subunit	subunit	NN
cord-001835-0s7ok4uw	125	14	interactions	interaction	NNS
cord-001835-0s7ok4uw	125	15	within	within	IN
cord-001835-0s7ok4uw	125	16	the	the	DT
cord-001835-0s7ok4uw	125	17	PhK	phk	JJ
cord-001835-0s7ok4uw	125	18	complex	complex	NN
cord-001835-0s7ok4uw	125	19	,	,	,
cord-001835-0s7ok4uw	125	20	and	and	CC
cord-001835-0s7ok4uw	125	21	augment	augment	VB
cord-001835-0s7ok4uw	125	22	previous	previous	JJ
cord-001835-0s7ok4uw	125	23	studies	study	NNS
cord-001835-0s7ok4uw	125	24	on	on	IN
cord-001835-0s7ok4uw	125	25	the	the	DT
cord-001835-0s7ok4uw	125	26	activation	activation	NN
cord-001835-0s7ok4uw	125	27	of	of	IN
cord-001835-0s7ok4uw	125	28	PhK	phk	NN
cord-001835-0s7ok4uw	125	29	by	by	IN
cord-001835-0s7ok4uw	125	30	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	125	31	in	in	IN
cord-001835-0s7ok4uw	125	32	which	which	WDT
cord-001835-0s7ok4uw	125	33	changes	change	VBZ
cord-001835-0s7ok4uw	125	34	at	at	IN
cord-001835-0s7ok4uw	125	35	the	the	DT
cord-001835-0s7ok4uw	125	36	Nterminus	Nterminus	NNP
cord-001835-0s7ok4uw	125	37	of	of	IN
cord-001835-0s7ok4uw	125	38	b	b	NNP
cord-001835-0s7ok4uw	125	39	are	be	VBP
cord-001835-0s7ok4uw	125	40	critical	critical	JJ
cord-001835-0s7ok4uw	125	41	in	in	IN
cord-001835-0s7ok4uw	125	42	the	the	DT
cord-001835-0s7ok4uw	125	43	activation	activation	NN
cord-001835-0s7ok4uw	125	44	of	of	IN
cord-001835-0s7ok4uw	125	45	the	the	DT
cord-001835-0s7ok4uw	125	46	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	125	47	g	g	NN
cord-001835-0s7ok4uw	125	48	subunit	subunit	NN
cord-001835-0s7ok4uw	125	49	.	.	.
cord-001835-0s7ok4uw	126	1	Summing	sum	VBG
cord-001835-0s7ok4uw	126	2	these	these	DT
cord-001835-0s7ok4uw	126	3	results	result	NNS
cord-001835-0s7ok4uw	126	4	leads	lead	VBZ
cord-001835-0s7ok4uw	126	5	to	to	IN
cord-001835-0s7ok4uw	126	6	a	a	DT
cord-001835-0s7ok4uw	126	7	new	new	JJ
cord-001835-0s7ok4uw	126	8	model	model	NN
cord-001835-0s7ok4uw	126	9	of	of	IN
cord-001835-0s7ok4uw	126	10	activation	activation	NN
cord-001835-0s7ok4uw	126	11	.	.	.
cord-001835-0s7ok4uw	127	1	In	in	IN
cord-001835-0s7ok4uw	127	2	this	this	DT
cord-001835-0s7ok4uw	127	3	model	model	NN
cord-001835-0s7ok4uw	127	4	,	,	,
cord-001835-0s7ok4uw	127	5	in	in	IN
cord-001835-0s7ok4uw	127	6	the	the	DT
cord-001835-0s7ok4uw	127	7	inactive	inactive	JJ
cord-001835-0s7ok4uw	127	8	state	state	NN
cord-001835-0s7ok4uw	127	9	,	,	,
cord-001835-0s7ok4uw	127	10	the	the	DT
cord-001835-0s7ok4uw	127	11	nonphosphorylated	nonphosphorylated	JJ
cord-001835-0s7ok4uw	127	12	N	N	NNP
cord-001835-0s7ok4uw	127	13	-	-	HYPH
cord-001835-0s7ok4uw	127	14	terminus	terminus	NN
cord-001835-0s7ok4uw	127	15	of	of	IN
cord-001835-0s7ok4uw	127	16	b	b	NN
cord-001835-0s7ok4uw	127	17	interacts	interact	VBZ
cord-001835-0s7ok4uw	127	18	directly	directly	RB
cord-001835-0s7ok4uw	127	19	or	or	CC
cord-001835-0s7ok4uw	127	20	indirectly	indirectly	RB
cord-001835-0s7ok4uw	127	21	with	with	IN
cord-001835-0s7ok4uw	127	22	the	the	DT
cord-001835-0s7ok4uw	127	23	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	127	24	C	c	NN
cord-001835-0s7ok4uw	127	25	-	-	HYPH
cord-001835-0s7ok4uw	127	26	terminal	terminal	NN
cord-001835-0s7ok4uw	127	27	domain	domain	NN
cord-001835-0s7ok4uw	127	28	of	of	IN
cord-001835-0s7ok4uw	127	29	the	the	DT
cord-001835-0s7ok4uw	127	30	g	g	NNP
cord-001835-0s7ok4uw	127	31	subunit	subunit	NN
cord-001835-0s7ok4uw	127	32	,	,	,
cord-001835-0s7ok4uw	127	33	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	127	34	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	127	35	activity	activity	NN
cord-001835-0s7ok4uw	127	36	.	.	.
cord-001835-0s7ok4uw	128	1	Upon	upon	IN
cord-001835-0s7ok4uw	128	2	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	128	3	of	of	IN
cord-001835-0s7ok4uw	128	4	the	the	DT
cord-001835-0s7ok4uw	128	5	N	n	CD
cord-001835-0s7ok4uw	128	6	-	-	HYPH
cord-001835-0s7ok4uw	128	7	terminus	terminus	NN
cord-001835-0s7ok4uw	128	8	of	of	IN
cord-001835-0s7ok4uw	128	9	b	b	NN
cord-001835-0s7ok4uw	128	10	,	,	,
cord-001835-0s7ok4uw	128	11	three	three	CD
cord-001835-0s7ok4uw	128	12	important	important	JJ
cord-001835-0s7ok4uw	128	13	events	event	NNS
cord-001835-0s7ok4uw	128	14	occur	occur	VBP
cord-001835-0s7ok4uw	128	15	:	:	:
cord-001835-0s7ok4uw	129	1	1	1	LS
cord-001835-0s7ok4uw	129	2	)	)	-RRB-
cord-001835-0s7ok4uw	129	3	the	the	DT
cord-001835-0s7ok4uw	129	4	interaction	interaction	NN
cord-001835-0s7ok4uw	129	5	between	between	IN
cord-001835-0s7ok4uw	129	6	b	b	NN
cord-001835-0s7ok4uw	129	7	and	and	CC
cord-001835-0s7ok4uw	129	8	g	g	NN
cord-001835-0s7ok4uw	129	9	is	be	VBZ
cord-001835-0s7ok4uw	129	10	disrupted	disrupt	VBN
cord-001835-0s7ok4uw	129	11	,	,	,
cord-001835-0s7ok4uw	129	12	2	2	CD
cord-001835-0s7ok4uw	129	13	)	)	-RRB-
cord-001835-0s7ok4uw	129	14	the	the	DT
cord-001835-0s7ok4uw	129	15	b	b	NN
cord-001835-0s7ok4uw	129	16	subunits	subunit	NNS
cord-001835-0s7ok4uw	129	17	of	of	IN
cord-001835-0s7ok4uw	129	18	the	the	DT
cord-001835-0s7ok4uw	129	19	holoenzyme	holoenzyme	NNP
cord-001835-0s7ok4uw	129	20	self	self	NN
cord-001835-0s7ok4uw	129	21	-	-	HYPH
cord-001835-0s7ok4uw	129	22	associate	associate	JJ
cord-001835-0s7ok4uw	129	23	,	,	,
cord-001835-0s7ok4uw	129	24	and	and	CC
cord-001835-0s7ok4uw	129	25	3	3	LS
cord-001835-0s7ok4uw	129	26	)	)	-RRB-
cord-001835-0s7ok4uw	129	27	the	the	DT
cord-001835-0s7ok4uw	129	28	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	129	29	domain	domain	NN
cord-001835-0s7ok4uw	129	30	is	be	VBZ
cord-001835-0s7ok4uw	129	31	activated	activate	VBN
cord-001835-0s7ok4uw	129	32	.	.	.
cord-001835-0s7ok4uw	130	1	Thus	thus	RB
cord-001835-0s7ok4uw	130	2	,	,	,
cord-001835-0s7ok4uw	130	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	130	4	envision	envision	VBP
cord-001835-0s7ok4uw	130	5	that	that	IN
cord-001835-0s7ok4uw	130	6	the	the	DT
cord-001835-0s7ok4uw	130	7	N	n	CD
cord-001835-0s7ok4uw	130	8	-	-	HYPH
cord-001835-0s7ok4uw	130	9	terminus	terminus	NN
cord-001835-0s7ok4uw	130	10	of	of	IN
cord-001835-0s7ok4uw	130	11	b	b	NN
cord-001835-0s7ok4uw	130	12	acts	act	VBZ
cord-001835-0s7ok4uw	130	13	as	as	IN
cord-001835-0s7ok4uw	130	14	an	an	DT
cord-001835-0s7ok4uw	130	15	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	130	16	switch	switch	NN
cord-001835-0s7ok4uw	130	17	,	,	,
cord-001835-0s7ok4uw	130	18	with	with	IN
cord-001835-0s7ok4uw	130	19	activation	activation	NN
cord-001835-0s7ok4uw	130	20	triggered	trigger	VBN
cord-001835-0s7ok4uw	130	21	by	by	IN
cord-001835-0s7ok4uw	130	22	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	130	23	of	of	IN
cord-001835-0s7ok4uw	130	24	this	this	DT
cord-001835-0s7ok4uw	130	25	region	region	NN
cord-001835-0s7ok4uw	130	26	,	,	,
cord-001835-0s7ok4uw	130	27	causing	cause	VBG
cord-001835-0s7ok4uw	130	28	disruption	disruption	NN
cord-001835-0s7ok4uw	130	29	of	of	IN
cord-001835-0s7ok4uw	130	30	its	-PRON-	PRP$
cord-001835-0s7ok4uw	130	31	previously	previously	RB
cord-001835-0s7ok4uw	130	32	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	130	33	interactions	interaction	NNS
cord-001835-0s7ok4uw	130	34	with	with	IN
cord-001835-0s7ok4uw	130	35	g	g	NN
cord-001835-0s7ok4uw	130	36	and	and	CC
cord-001835-0s7ok4uw	130	37	promotion	promotion	NN
cord-001835-0s7ok4uw	130	38	of	of	IN
cord-001835-0s7ok4uw	130	39	b	b	NN
cord-001835-0s7ok4uw	130	40	b	b	NN
cord-001835-0s7ok4uw	130	41	dimerization	dimerization	NN
cord-001835-0s7ok4uw	130	42	to	to	TO
cord-001835-0s7ok4uw	130	43	stabilize	stabilize	VB
cord-001835-0s7ok4uw	130	44	the	the	DT
cord-001835-0s7ok4uw	130	45	activated	activate	VBN
cord-001835-0s7ok4uw	130	46	conformation	conformation	NN
cord-001835-0s7ok4uw	130	47	of	of	IN
cord-001835-0s7ok4uw	130	48	g	g	NN
cord-001835-0s7ok4uw	130	49	.	.	.
cord-001835-0s7ok4uw	131	1	The	the	DT
cord-001835-0s7ok4uw	131	2	research	research	NN
cord-001835-0s7ok4uw	131	3	was	be	VBD
cord-001835-0s7ok4uw	131	4	supported	support	VBN
cord-001835-0s7ok4uw	131	5	financially	financially	RB
cord-001835-0s7ok4uw	131	6	by	by	IN
cord-001835-0s7ok4uw	131	7	the	the	DT
cord-001835-0s7ok4uw	131	8	University	University	NNP
cord-001835-0s7ok4uw	131	9	of	of	IN
cord-001835-0s7ok4uw	131	10	Kansas	Kansas	NNP
cord-001835-0s7ok4uw	131	11	Medical	Medical	NNP
cord-001835-0s7ok4uw	131	12	Center	Center	NNP
cord-001835-0s7ok4uw	131	13	Biomedical	Biomedical	NNP
cord-001835-0s7ok4uw	131	14	Research	Research	NNP
cord-001835-0s7ok4uw	131	15	Training	Training	NNP
cord-001835-0s7ok4uw	131	16	Program	Program	NNP
cord-001835-0s7ok4uw	131	17	and	and	CC
cord-001835-0s7ok4uw	131	18	NIH	NIH	NNP
cord-001835-0s7ok4uw	131	19	Grant	Grant	NNP
cord-001835-0s7ok4uw	131	20	DK32953	DK32953	NNS
cord-001835-0s7ok4uw	131	21	.	.	.
cord-001835-0s7ok4uw	132	1	PB-032	PB-032	NNP
cord-001835-0s7ok4uw	132	2	hSSB1	hSSB1	NNP
cord-001835-0s7ok4uw	132	3	is	be	VBZ
cord-001835-0s7ok4uw	132	4	involved	involve	VBN
cord-001835-0s7ok4uw	132	5	in	in	IN
cord-001835-0s7ok4uw	132	6	the	the	DT
cord-001835-0s7ok4uw	132	7	cellular	cellular	JJ
cord-001835-0s7ok4uw	132	8	response	response	NN
cord-001835-0s7ok4uw	132	9	to	to	IN
cord-001835-0s7ok4uw	132	10	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	132	11	DNA	dna	NN
cord-001835-0s7ok4uw	132	12	damage	damage	NN
cord-001835-0s7ok4uw	132	13	Christine	Christine	NNP
cord-001835-0s7ok4uw	132	14	Touma	Touma	NNP
cord-001835-0s7ok4uw	132	15	1	1	CD
cord-001835-0s7ok4uw	132	16	,	,	,
cord-001835-0s7ok4uw	132	17	Nicolas	Nicolas	NNP
cord-001835-0s7ok4uw	132	18	Paquet	Paquet	NNP
cord-001835-0s7ok4uw	132	19	2	2	CD
cord-001835-0s7ok4uw	132	20	,	,	,
cord-001835-0s7ok4uw	132	21	Derek	Derek	NNP
cord-001835-0s7ok4uw	132	22	J.	J.	NNP
cord-001835-0s7ok4uw	132	23	Richard	Richard	NNP
cord-001835-0s7ok4uw	132	24	2	2	CD
cord-001835-0s7ok4uw	132	25	,	,	,
cord-001835-0s7ok4uw	132	26	Roland	Roland	NNP
cord-001835-0s7ok4uw	132	27	Gamsjaeger	Gamsjaeger	NNP
cord-001835-0s7ok4uw	132	28	1,3	1,3	CD
cord-001835-0s7ok4uw	132	29	,	,	,
cord-001835-0s7ok4uw	132	30	Liza	Liza	NNP
cord-001835-0s7ok4uw	132	31	Cubeddu	Cubeddu	NNP
cord-001835-0s7ok4uw	132	32	1,3	1,3	CD
cord-001835-0s7ok4uw	132	33	1	1	CD
cord-001835-0s7ok4uw	132	34	School	School	NNP
cord-001835-0s7ok4uw	132	35	of	of	IN
cord-001835-0s7ok4uw	132	36	Science	Science	NNP
cord-001835-0s7ok4uw	132	37	and	and	CC
cord-001835-0s7ok4uw	132	38	Health	Health	NNP
cord-001835-0s7ok4uw	132	39	,	,	,
cord-001835-0s7ok4uw	132	40	University	University	NNP
cord-001835-0s7ok4uw	132	41	of	of	IN
cord-001835-0s7ok4uw	132	42	Western	Western	NNP
cord-001835-0s7ok4uw	132	43	Sydney	Sydney	NNP
cord-001835-0s7ok4uw	132	44	,	,	,
cord-001835-0s7ok4uw	132	45	2	2	CD
cord-001835-0s7ok4uw	132	46	Queensland	Queensland	NNP
cord-001835-0s7ok4uw	132	47	University	University	NNP
cord-001835-0s7ok4uw	132	48	of	of	IN
cord-001835-0s7ok4uw	132	49	Te	Te	NNP
cord-001835-0s7ok4uw	132	50	chnology	chnology	NN
cord-001835-0s7ok4uw	132	51	,	,	,
cord-001835-0s7ok4uw	133	1	3	3	LS
cord-001835-0s7ok4uw	133	2	School	School	NNP
cord-001835-0s7ok4uw	133	3	of	of	IN
cord-001835-0s7ok4uw	133	4	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	133	5	Bioscience	Bioscience	NNP
cord-001835-0s7ok4uw	133	6	,	,	,
cord-001835-0s7ok4uw	133	7	University	University	NNP
cord-001835-0s7ok4uw	133	8	of	of	IN
cord-001835-0s7ok4uw	133	9	Sydney	Sydney	NNP
cord-001835-0s7ok4uw	133	10	Cellular	Cellular	NNP
cord-001835-0s7ok4uw	133	11	DNA	DNA	NNP
cord-001835-0s7ok4uw	133	12	is	be	VBZ
cord-001835-0s7ok4uw	133	13	subject	subject	JJ
cord-001835-0s7ok4uw	133	14	to	to	IN
cord-001835-0s7ok4uw	133	15	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	133	16	damage	damage	NN
cord-001835-0s7ok4uw	133	17	in	in	IN
cord-001835-0s7ok4uw	133	18	the	the	DT
cord-001835-0s7ok4uw	133	19	presence	presence	NN
cord-001835-0s7ok4uw	133	20	of	of	IN
cord-001835-0s7ok4uw	133	21	reactive	reactive	JJ
cord-001835-0s7ok4uw	133	22	oxygen	oxygen	NN
cord-001835-0s7ok4uw	133	23	species	specie	NNS
cord-001835-0s7ok4uw	133	24	.	.	.
cord-001835-0s7ok4uw	134	1	The	the	DT
cord-001835-0s7ok4uw	134	2	7,8-dihydro-8-oxoguanine	7,8-dihydro-8-oxoguanine	CD
cord-001835-0s7ok4uw	134	3	(	(	-LRB-
cord-001835-0s7ok4uw	134	4	8-oxoG	8-oxog	CD
cord-001835-0s7ok4uw	134	5	)	)	-RRB-
cord-001835-0s7ok4uw	134	6	adduct	adduct	NN
cord-001835-0s7ok4uw	134	7	is	be	VBZ
cord-001835-0s7ok4uw	134	8	the	the	DT
cord-001835-0s7ok4uw	134	9	most	most	RBS
cord-001835-0s7ok4uw	134	10	common	common	JJ
cord-001835-0s7ok4uw	134	11	form	form	NN
cord-001835-0s7ok4uw	134	12	of	of	IN
cord-001835-0s7ok4uw	134	13	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	134	14	damage	damage	NN
cord-001835-0s7ok4uw	134	15	and	and	CC
cord-001835-0s7ok4uw	134	16	results	result	NNS
cord-001835-0s7ok4uw	134	17	in	in	IN
cord-001835-0s7ok4uw	134	18	G	g	NN
cord-001835-0s7ok4uw	134	19	:	:	:
cord-001835-0s7ok4uw	134	20	C	c	NN
cord-001835-0s7ok4uw	134	21	to	to	IN
cord-001835-0s7ok4uw	134	22	T	t	NN
cord-001835-0s7ok4uw	134	23	:	:	:
cord-001835-0s7ok4uw	135	1	A	a	DT
cord-001835-0s7ok4uw	135	2	transversions	transversion	NNS
cord-001835-0s7ok4uw	135	3	;	;	:
cord-001835-0s7ok4uw	135	4	these	these	DT
cord-001835-0s7ok4uw	135	5	lesions	lesion	NNS
cord-001835-0s7ok4uw	135	6	are	be	VBP
cord-001835-0s7ok4uw	135	7	normally	normally	RB
cord-001835-0s7ok4uw	135	8	processed	process	VBN
cord-001835-0s7ok4uw	135	9	by	by	IN
cord-001835-0s7ok4uw	135	10	the	the	DT
cord-001835-0s7ok4uw	135	11	Base	Base	NNP
cord-001835-0s7ok4uw	135	12	Excision	Excision	NNP
cord-001835-0s7ok4uw	135	13	Repair	Repair	NNP
cord-001835-0s7ok4uw	135	14	(	(	-LRB-
cord-001835-0s7ok4uw	135	15	BER	BER	NNP
cord-001835-0s7ok4uw	135	16	)	)	-RRB-
cord-001835-0s7ok4uw	135	17	pathway	pathway	NN
cord-001835-0s7ok4uw	135	18	.	.	.
cord-001835-0s7ok4uw	136	1	Singlestranded	Singlestranded	NNP
cord-001835-0s7ok4uw	136	2	binding	binding	NN
cord-001835-0s7ok4uw	136	3	(	(	-LRB-
cord-001835-0s7ok4uw	136	4	SSB	SSB	NNP
cord-001835-0s7ok4uw	136	5	)	)	-RRB-
cord-001835-0s7ok4uw	136	6	proteins	protein	NNS
cord-001835-0s7ok4uw	136	7	of	of	IN
cord-001835-0s7ok4uw	136	8	the	the	DT
cord-001835-0s7ok4uw	136	9	oligonucleotide	oligonucleotide	JJ
cord-001835-0s7ok4uw	136	10	binding	bind	VBG
cord-001835-0s7ok4uw	136	11	domain	domain	NN
cord-001835-0s7ok4uw	136	12	family	family	NN
cord-001835-0s7ok4uw	136	13	are	be	VBP
cord-001835-0s7ok4uw	136	14	heavily	heavily	RB
cord-001835-0s7ok4uw	136	15	involved	involve	VBN
cord-001835-0s7ok4uw	136	16	in	in	IN
cord-001835-0s7ok4uw	136	17	DNA	dna	NN
cord-001835-0s7ok4uw	136	18	repair	repair	NN
cord-001835-0s7ok4uw	136	19	processes	process	NNS
cord-001835-0s7ok4uw	136	20	,	,	,
cord-001835-0s7ok4uw	136	21	which	which	WDT
cord-001835-0s7ok4uw	136	22	involve	involve	VBP
cord-001835-0s7ok4uw	136	23	the	the	DT
cord-001835-0s7ok4uw	136	24	detection	detection	NN
cord-001835-0s7ok4uw	136	25	of	of	IN
cord-001835-0s7ok4uw	136	26	DNA	dna	NN
cord-001835-0s7ok4uw	136	27	damage	damage	NN
cord-001835-0s7ok4uw	136	28	and	and	CC
cord-001835-0s7ok4uw	136	29	recruitment	recruitment	NN
cord-001835-0s7ok4uw	136	30	of	of	IN
cord-001835-0s7ok4uw	136	31	repair	repair	NN
cord-001835-0s7ok4uw	136	32	proteins	protein	NNS
cord-001835-0s7ok4uw	136	33	to	to	IN
cord-001835-0s7ok4uw	136	34	the	the	DT
cord-001835-0s7ok4uw	136	35	site	site	NN
cord-001835-0s7ok4uw	136	36	of	of	IN
cord-001835-0s7ok4uw	136	37	damage	damage	NN
cord-001835-0s7ok4uw	136	38	.	.	.
cord-001835-0s7ok4uw	137	1	Using	use	VBG
cord-001835-0s7ok4uw	137	2	immunofluorescence	immunofluorescence	NN
cord-001835-0s7ok4uw	137	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	137	4	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	137	5	that	that	IN
cord-001835-0s7ok4uw	137	6	hSSB1	hssb1	NN
cord-001835-0s7ok4uw	137	7	(	(	-LRB-
cord-001835-0s7ok4uw	137	8	a	a	DT
cord-001835-0s7ok4uw	137	9	novel	novel	JJ
cord-001835-0s7ok4uw	137	10	human	human	JJ
cord-001835-0s7ok4uw	137	11	SSB	ssb	NN
cord-001835-0s7ok4uw	137	12	)	)	-RRB-
cord-001835-0s7ok4uw	137	13	levels	level	NNS
cord-001835-0s7ok4uw	137	14	increase	increase	VBP
cord-001835-0s7ok4uw	137	15	in	in	IN
cord-001835-0s7ok4uw	137	16	response	response	NN
cord-001835-0s7ok4uw	137	17	to	to	IN
cord-001835-0s7ok4uw	137	18	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	137	19	damage	damage	NN
cord-001835-0s7ok4uw	137	20	(	(	-LRB-
cord-001835-0s7ok4uw	137	21	H202	H202	NNP
cord-001835-0s7ok4uw	137	22	)	)	-RRB-
cord-001835-0s7ok4uw	137	23	.	.	.
cord-001835-0s7ok4uw	138	1	Cells	cell	NNS
cord-001835-0s7ok4uw	138	2	depleted	deplete	VBN
cord-001835-0s7ok4uw	138	3	of	of	IN
cord-001835-0s7ok4uw	138	4	hSSB1	hSSB1	NNP
cord-001835-0s7ok4uw	138	5	are	be	VBP
cord-001835-0s7ok4uw	138	6	hypersensitive	hypersensitive	JJ
cord-001835-0s7ok4uw	138	7	to	to	IN
cord-001835-0s7ok4uw	138	8	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	138	9	damage	damage	NN
cord-001835-0s7ok4uw	138	10	and	and	CC
cord-001835-0s7ok4uw	138	11	are	be	VBP
cord-001835-0s7ok4uw	138	12	also	also	RB
cord-001835-0s7ok4uw	138	13	unable	unable	JJ
cord-001835-0s7ok4uw	138	14	to	to	TO
cord-001835-0s7ok4uw	138	15	efficiently	efficiently	RB
cord-001835-0s7ok4uw	138	16	remove	remove	VB
cord-001835-0s7ok4uw	138	17	8-oxoG	8-oxog	CD
cord-001835-0s7ok4uw	138	18	adducts	adduct	NNS
cord-001835-0s7ok4uw	138	19	.	.	.
cord-001835-0s7ok4uw	139	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	139	2	show	show	VBP
cord-001835-0s7ok4uw	139	3	that	that	IN
cord-001835-0s7ok4uw	139	4	hSSB1	hSSB1	NNP
cord-001835-0s7ok4uw	139	5	forms	form	VBZ
cord-001835-0s7ok4uw	139	6	dimers	dimer	NNS
cord-001835-0s7ok4uw	139	7	and	and	CC
cord-001835-0s7ok4uw	139	8	tetramers	tetramer	NNS
cord-001835-0s7ok4uw	139	9	under	under	IN
cord-001835-0s7ok4uw	139	10	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	139	11	conditions	condition	NNS
cord-001835-0s7ok4uw	139	12	and	and	CC
cord-001835-0s7ok4uw	139	13	that	that	IN
cord-001835-0s7ok4uw	139	14	this	this	DT
cord-001835-0s7ok4uw	139	15	oligomerisation	oligomerisation	NN
cord-001835-0s7ok4uw	139	16	is	be	VBZ
cord-001835-0s7ok4uw	139	17	likely	likely	RB
cord-001835-0s7ok4uw	139	18	mediated	mediate	VBN
cord-001835-0s7ok4uw	139	19	by	by	IN
cord-001835-0s7ok4uw	139	20	inter	inter	JJ
cord-001835-0s7ok4uw	139	21	-	-	NN
cord-001835-0s7ok4uw	139	22	domain	domain	JJ
cord-001835-0s7ok4uw	139	23	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	139	24	bond	bond	NN
cord-001835-0s7ok4uw	139	25	formation	formation	NN
cord-001835-0s7ok4uw	139	26	.	.	.
cord-001835-0s7ok4uw	140	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	140	2	,	,	,
cord-001835-0s7ok4uw	140	3	using	use	VBG
cord-001835-0s7ok4uw	140	4	Surface	Surface	NNP
cord-001835-0s7ok4uw	140	5	Plasmon	Plasmon	NNP
cord-001835-0s7ok4uw	140	6	Resonance	Resonance	NNP
cord-001835-0s7ok4uw	140	7	,	,	,
cord-001835-0s7ok4uw	140	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	140	9	also	also	RB
cord-001835-0s7ok4uw	140	10	show	show	VBP
cord-001835-0s7ok4uw	140	11	that	that	IN
cord-001835-0s7ok4uw	140	12	oxidised	oxidise	VBN
cord-001835-0s7ok4uw	140	13	hSSB1	hSSB1	NNP
cord-001835-0s7ok4uw	140	14	binds	bind	VBZ
cord-001835-0s7ok4uw	140	15	to	to	IN
cord-001835-0s7ok4uw	140	16	8-oxo	8-oxo	NN
cord-001835-0s7ok4uw	140	17	-	-	HYPH
cord-001835-0s7ok4uw	140	18	G	g	NN
cord-001835-0s7ok4uw	140	19	damaged	damage	VBD
cord-001835-0s7ok4uw	140	20	ssDNA	ssdna	NN
cord-001835-0s7ok4uw	140	21	with	with	IN
cord-001835-0s7ok4uw	140	22	higher	high	JJR
cord-001835-0s7ok4uw	140	23	affinity	affinity	NN
cord-001835-0s7ok4uw	140	24	than	than	IN
cord-001835-0s7ok4uw	140	25	non	non	JJ
cord-001835-0s7ok4uw	140	26	-	-	JJ
cord-001835-0s7ok4uw	140	27	damaged	damaged	JJ
cord-001835-0s7ok4uw	140	28	ssDNA	ssdna	NN
cord-001835-0s7ok4uw	140	29	,	,	,
cord-001835-0s7ok4uw	140	30	indicating	indicate	VBG
cord-001835-0s7ok4uw	140	31	a	a	DT
cord-001835-0s7ok4uw	140	32	direct	direct	JJ
cord-001835-0s7ok4uw	140	33	role	role	NN
cord-001835-0s7ok4uw	140	34	for	for	IN
cord-001835-0s7ok4uw	140	35	oxidised	oxidise	VBN
cord-001835-0s7ok4uw	140	36	hSSB1	hssb1	NN
cord-001835-0s7ok4uw	140	37	in	in	IN
cord-001835-0s7ok4uw	140	38	the	the	DT
cord-001835-0s7ok4uw	140	39	recognition	recognition	NN
cord-001835-0s7ok4uw	140	40	of	of	IN
cord-001835-0s7ok4uw	140	41	8-oxo	8-oxo	CD
cord-001835-0s7ok4uw	140	42	-	-	HYPH
cord-001835-0s7ok4uw	140	43	G	g	NN
cord-001835-0s7ok4uw	140	44	lesions	lesion	NNS
cord-001835-0s7ok4uw	140	45	.	.	.
cord-001835-0s7ok4uw	141	1	As	as	IN
cord-001835-0s7ok4uw	141	2	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	141	3	stress	stress	NN
cord-001835-0s7ok4uw	141	4	is	be	VBZ
cord-001835-0s7ok4uw	141	5	associated	associate	VBN
cord-001835-0s7ok4uw	141	6	with	with	IN
cord-001835-0s7ok4uw	141	7	aging	age	VBG
cord-001835-0s7ok4uw	141	8	,	,	,
cord-001835-0s7ok4uw	141	9	cancer	cancer	NN
cord-001835-0s7ok4uw	141	10	and	and	CC
cord-001835-0s7ok4uw	141	11	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	141	12	's	's	POS
cord-001835-0s7ok4uw	141	13	disease	disease	NN
cord-001835-0s7ok4uw	141	14	,	,	,
cord-001835-0s7ok4uw	141	15	understanding	understand	VBG
cord-001835-0s7ok4uw	141	16	the	the	DT
cord-001835-0s7ok4uw	141	17	molecular	molecular	JJ
cord-001835-0s7ok4uw	141	18	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	141	19	of	of	IN
cord-001835-0s7ok4uw	141	20	how	how	WRB
cord-001835-0s7ok4uw	141	21	cells	cell	NNS
cord-001835-0s7ok4uw	141	22	repair	repair	VBP
cord-001835-0s7ok4uw	141	23	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	141	24	DNA	dna	NN
cord-001835-0s7ok4uw	141	25	damage	damage	NN
cord-001835-0s7ok4uw	141	26	will	will	MD
cord-001835-0s7ok4uw	141	27	be	be	VB
cord-001835-0s7ok4uw	141	28	crucial	crucial	JJ
cord-001835-0s7ok4uw	141	29	in	in	IN
cord-001835-0s7ok4uw	141	30	the	the	DT
cord-001835-0s7ok4uw	141	31	development	development	NN
cord-001835-0s7ok4uw	141	32	of	of	IN
cord-001835-0s7ok4uw	141	33	potential	potential	JJ
cord-001835-0s7ok4uw	141	34	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	141	35	treatments	treatment	NNS
cord-001835-0s7ok4uw	141	36	.	.	.
cord-001835-0s7ok4uw	141	37	 	 	_SP
cord-001835-0s7ok4uw	142	1	Epidemic	epidemic	NN
cord-001835-0s7ok4uw	142	2	typhus	typhus	NN
cord-001835-0s7ok4uw	142	3	,	,	,
cord-001835-0s7ok4uw	142	4	which	which	WDT
cord-001835-0s7ok4uw	142	5	is	be	VBZ
cord-001835-0s7ok4uw	142	6	caused	cause	VBN
cord-001835-0s7ok4uw	142	7	by	by	IN
cord-001835-0s7ok4uw	142	8	the	the	DT
cord-001835-0s7ok4uw	142	9	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	142	10	pathogen	pathogen	NN
cord-001835-0s7ok4uw	142	11	Rickettsia	Rickettsia	NNP
cord-001835-0s7ok4uw	142	12	prowazekii	prowazekii	NNS
cord-001835-0s7ok4uw	142	13	,	,	,
cord-001835-0s7ok4uw	142	14	is	be	VBZ
cord-001835-0s7ok4uw	142	15	a	a	DT
cord-001835-0s7ok4uw	142	16	menacing	menacing	JJ
cord-001835-0s7ok4uw	142	17	disease	disease	NN
cord-001835-0s7ok4uw	142	18	world	world	NN
cord-001835-0s7ok4uw	142	19	wide	wide	JJ
cord-001835-0s7ok4uw	142	20	that	that	IN
cord-001835-0s7ok4uw	142	21	the	the	DT
cord-001835-0s7ok4uw	142	22	NIH	NIH	NNP
cord-001835-0s7ok4uw	142	23	lists	list	NNS
cord-001835-0s7ok4uw	142	24	as	as	IN
cord-001835-0s7ok4uw	142	25	one	one	CD
cord-001835-0s7ok4uw	142	26	of	of	IN
cord-001835-0s7ok4uw	142	27	America	America	NNP
cord-001835-0s7ok4uw	142	28	's	's	POS
cord-001835-0s7ok4uw	142	29	greatest	great	JJS
cord-001835-0s7ok4uw	142	30	biological	biological	JJ
cord-001835-0s7ok4uw	142	31	weapons	weapon	NNS
cord-001835-0s7ok4uw	142	32	threats	threat	NNS
cord-001835-0s7ok4uw	142	33	.	.	.
cord-001835-0s7ok4uw	143	1	This	this	DT
cord-001835-0s7ok4uw	143	2	research	research	NN
cord-001835-0s7ok4uw	143	3	seeks	seek	VBZ
cord-001835-0s7ok4uw	143	4	to	to	TO
cord-001835-0s7ok4uw	143	5	find	find	VB
cord-001835-0s7ok4uw	143	6	novel	novel	JJ
cord-001835-0s7ok4uw	143	7	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	143	8	of	of	IN
cord-001835-0s7ok4uw	143	9	b	b	NNP
cord-001835-0s7ok4uw	143	10	-	-	HYPH
cord-001835-0s7ok4uw	143	11	ketoacyl	ketoacyl	JJ
cord-001835-0s7ok4uw	143	12	-	-	HYPH
cord-001835-0s7ok4uw	143	13	ACP	acp	NN
cord-001835-0s7ok4uw	143	14	-	-	HYPH
cord-001835-0s7ok4uw	143	15	reductase	reductase	NN
cord-001835-0s7ok4uw	143	16	(	(	-LRB-
cord-001835-0s7ok4uw	143	17	FabG	FabG	NNP
cord-001835-0s7ok4uw	143	18	)	)	-RRB-
cord-001835-0s7ok4uw	143	19	,	,	,
cord-001835-0s7ok4uw	143	20	an	an	DT
cord-001835-0s7ok4uw	143	21	enzyme	enzyme	NN
cord-001835-0s7ok4uw	143	22	that	that	WDT
cord-001835-0s7ok4uw	143	23	catalyzes	catalyze	VBZ
cord-001835-0s7ok4uw	143	24	one	one	CD
cord-001835-0s7ok4uw	143	25	of	of	IN
cord-001835-0s7ok4uw	143	26	the	the	DT
cord-001835-0s7ok4uw	143	27	reactions	reaction	NNS
cord-001835-0s7ok4uw	143	28	in	in	IN
cord-001835-0s7ok4uw	143	29	the	the	DT
cord-001835-0s7ok4uw	143	30	fatty	fatty	JJ
cord-001835-0s7ok4uw	143	31	acid	acid	NN
cord-001835-0s7ok4uw	143	32	synthesis	synthesis	NN
cord-001835-0s7ok4uw	143	33	type	type	NN
cord-001835-0s7ok4uw	143	34	II	II	NNP
cord-001835-0s7ok4uw	143	35	system	system	NN
cord-001835-0s7ok4uw	143	36	in	in	IN
cord-001835-0s7ok4uw	143	37	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	143	38	.	.	.
cord-001835-0s7ok4uw	144	1	This	this	DT
cord-001835-0s7ok4uw	144	2	pathway	pathway	NN
cord-001835-0s7ok4uw	144	3	is	be	VBZ
cord-001835-0s7ok4uw	144	4	essential	essential	JJ
cord-001835-0s7ok4uw	144	5	for	for	IN
cord-001835-0s7ok4uw	144	6	survival	survival	NN
cord-001835-0s7ok4uw	144	7	in	in	IN
cord-001835-0s7ok4uw	144	8	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	144	9	.	.	.
cord-001835-0s7ok4uw	145	1	The	the	DT
cord-001835-0s7ok4uw	145	2	FabG	FabG	NNP
cord-001835-0s7ok4uw	145	3	enzyme	enzyme	NN
cord-001835-0s7ok4uw	145	4	uses	use	VBZ
cord-001835-0s7ok4uw	145	5	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	145	6	as	as	IN
cord-001835-0s7ok4uw	145	7	a	a	DT
cord-001835-0s7ok4uw	145	8	substrate	substrate	NN
cord-001835-0s7ok4uw	145	9	,	,	,
cord-001835-0s7ok4uw	145	10	which	which	WDT
cord-001835-0s7ok4uw	145	11	facilitates	facilitate	VBZ
cord-001835-0s7ok4uw	145	12	the	the	DT
cord-001835-0s7ok4uw	145	13	binding	binding	NN
cord-001835-0s7ok4uw	145	14	of	of	IN
cord-001835-0s7ok4uw	145	15	the	the	DT
cord-001835-0s7ok4uw	145	16	second	second	JJ
cord-001835-0s7ok4uw	145	17	substrate	substrate	NN
cord-001835-0s7ok4uw	145	18	,	,	,
cord-001835-0s7ok4uw	145	19	acetoacetyl	acetoacetyl	NNP
cord-001835-0s7ok4uw	145	20	-	-	HYPH
cord-001835-0s7ok4uw	145	21	ACP	ACP	NNP
cord-001835-0s7ok4uw	145	22	into	into	IN
cord-001835-0s7ok4uw	145	23	the	the	DT
cord-001835-0s7ok4uw	145	24	active	active	JJ
cord-001835-0s7ok4uw	145	25	site	site	NN
cord-001835-0s7ok4uw	145	26	.	.	.
cord-001835-0s7ok4uw	146	1	The	the	DT
cord-001835-0s7ok4uw	146	2	acetoacetyl	acetoacetyl	NNP
cord-001835-0s7ok4uw	146	3	-	-	HYPH
cord-001835-0s7ok4uw	146	4	ACP	ACP	NNP
cord-001835-0s7ok4uw	146	5	is	be	VBZ
cord-001835-0s7ok4uw	146	6	subsequently	subsequently	RB
cord-001835-0s7ok4uw	146	7	reduced	reduce	VBN
cord-001835-0s7ok4uw	146	8	into	into	IN
cord-001835-0s7ok4uw	146	9	b	b	LS
cord-001835-0s7ok4uw	146	10	-	-	HYPH
cord-001835-0s7ok4uw	146	11	hydroxyacyl	hydroxyacyl	NNP
cord-001835-0s7ok4uw	146	12	-	-	HYPH
cord-001835-0s7ok4uw	146	13	ACP	ACP	NNP
cord-001835-0s7ok4uw	146	14	.	.	.
cord-001835-0s7ok4uw	147	1	The	the	DT
cord-001835-0s7ok4uw	147	2	coding	code	VBG
cord-001835-0s7ok4uw	147	3	DNA	dna	NN
cord-001835-0s7ok4uw	147	4	sequence	sequence	NN
cord-001835-0s7ok4uw	147	5	for	for	IN
cord-001835-0s7ok4uw	147	6	the	the	DT
cord-001835-0s7ok4uw	147	7	RpFabG	RpFabG	NNP
cord-001835-0s7ok4uw	147	8	protein	protein	NN
cord-001835-0s7ok4uw	147	9	was	be	VBD
cord-001835-0s7ok4uw	147	10	cloned	clone	VBN
cord-001835-0s7ok4uw	147	11	into	into	IN
cord-001835-0s7ok4uw	147	12	a	a	DT
cord-001835-0s7ok4uw	147	13	pNIC	pnic	JJ
cord-001835-0s7ok4uw	147	14	vector	vector	NN
cord-001835-0s7ok4uw	147	15	and	and	CC
cord-001835-0s7ok4uw	147	16	transformed	transform	VBN
cord-001835-0s7ok4uw	147	17	into	into	IN
cord-001835-0s7ok4uw	147	18	E.coli	E.coli	NNS
cord-001835-0s7ok4uw	147	19	BL21(DE3	BL21(DE3	NNP
cord-001835-0s7ok4uw	147	20	)	)	-RRB-
cord-001835-0s7ok4uw	147	21	,	,	,
cord-001835-0s7ok4uw	147	22	then	then	RB
cord-001835-0s7ok4uw	147	23	the	the	DT
cord-001835-0s7ok4uw	147	24	protein	protein	NN
cord-001835-0s7ok4uw	147	25	was	be	VBD
cord-001835-0s7ok4uw	147	26	expressed	express	VBN
cord-001835-0s7ok4uw	147	27	and	and	CC
cord-001835-0s7ok4uw	147	28	purified	purify	VBN
cord-001835-0s7ok4uw	147	29	using	use	VBG
cord-001835-0s7ok4uw	147	30	metal	metal	NN
cord-001835-0s7ok4uw	147	31	affinity	affinity	NN
cord-001835-0s7ok4uw	147	32	and	and	CC
cord-001835-0s7ok4uw	147	33	size	size	NN
cord-001835-0s7ok4uw	147	34	exclusion	exclusion	NN
cord-001835-0s7ok4uw	147	35	chromatography	chromatography	NN
cord-001835-0s7ok4uw	147	36	methods	method	NNS
cord-001835-0s7ok4uw	147	37	.	.	.
cord-001835-0s7ok4uw	148	1	High	high	JJ
cord-001835-0s7ok4uw	148	2	throughput	throughput	NN
cord-001835-0s7ok4uw	148	3	molecular	molecular	JJ
cord-001835-0s7ok4uw	148	4	docking	docking	NN
cord-001835-0s7ok4uw	148	5	software	software	NN
cord-001835-0s7ok4uw	148	6	(	(	-LRB-
cord-001835-0s7ok4uw	148	7	GOLD	gold	NN
cord-001835-0s7ok4uw	148	8	)	)	-RRB-
cord-001835-0s7ok4uw	148	9	was	be	VBD
cord-001835-0s7ok4uw	148	10	used	use	VBN
cord-001835-0s7ok4uw	148	11	to	to	TO
cord-001835-0s7ok4uw	148	12	screen	screen	VB
cord-001835-0s7ok4uw	148	13	a	a	DT
cord-001835-0s7ok4uw	148	14	commercial	commercial	JJ
cord-001835-0s7ok4uw	148	15	library	library	NN
cord-001835-0s7ok4uw	148	16	of	of	IN
cord-001835-0s7ok4uw	148	17	ligands	ligand	NNS
cord-001835-0s7ok4uw	148	18	against	against	IN
cord-001835-0s7ok4uw	148	19	the	the	DT
cord-001835-0s7ok4uw	148	20	acetoacetyl	acetoacetyl	NNP
cord-001835-0s7ok4uw	148	21	-	-	HYPH
cord-001835-0s7ok4uw	148	22	ACP	ACP	NNP
cord-001835-0s7ok4uw	148	23	region	region	NN
cord-001835-0s7ok4uw	148	24	of	of	IN
cord-001835-0s7ok4uw	148	25	the	the	DT
cord-001835-0s7ok4uw	148	26	active	active	JJ
cord-001835-0s7ok4uw	148	27	site	site	NN
cord-001835-0s7ok4uw	148	28	.	.	.
cord-001835-0s7ok4uw	149	1	The	the	DT
cord-001835-0s7ok4uw	149	2	ligands	ligand	NNS
cord-001835-0s7ok4uw	149	3	with	with	IN
cord-001835-0s7ok4uw	149	4	the	the	DT
cord-001835-0s7ok4uw	149	5	best	good	JJS
cord-001835-0s7ok4uw	149	6	GOLD	gold	NN
cord-001835-0s7ok4uw	149	7	scores	score	NNS
cord-001835-0s7ok4uw	149	8	were	be	VBD
cord-001835-0s7ok4uw	149	9	selected	select	VBN
cord-001835-0s7ok4uw	149	10	to	to	TO
cord-001835-0s7ok4uw	149	11	be	be	VB
cord-001835-0s7ok4uw	149	12	tested	test	VBN
cord-001835-0s7ok4uw	149	13	in	in	IN
cord-001835-0s7ok4uw	149	14	vitro	vitro	FW
cord-001835-0s7ok4uw	149	15	.	.	.
cord-001835-0s7ok4uw	150	1	Spectrophotometric	spectrophotometric	JJ
cord-001835-0s7ok4uw	150	2	enzyme	enzyme	NN
cord-001835-0s7ok4uw	150	3	inhibition	inhibition	NN
cord-001835-0s7ok4uw	150	4	assays	assay	NNS
cord-001835-0s7ok4uw	150	5	were	be	VBD
cord-001835-0s7ok4uw	150	6	performed	perform	VBN
cord-001835-0s7ok4uw	150	7	to	to	TO
cord-001835-0s7ok4uw	150	8	determine	determine	VB
cord-001835-0s7ok4uw	150	9	whether	whether	IN
cord-001835-0s7ok4uw	150	10	the	the	DT
cord-001835-0s7ok4uw	150	11	drugs	drug	NNS
cord-001835-0s7ok4uw	150	12	could	could	MD
cord-001835-0s7ok4uw	150	13	inhibit	inhibit	VB
cord-001835-0s7ok4uw	150	14	RpFabG	RpFabG	NNP
cord-001835-0s7ok4uw	150	15	activity	activity	NN
cord-001835-0s7ok4uw	150	16	.	.	.
cord-001835-0s7ok4uw	151	1	Chlorogenic	chlorogenic	JJ
cord-001835-0s7ok4uw	151	2	acid	acid	NN
cord-001835-0s7ok4uw	151	3	,	,	,
cord-001835-0s7ok4uw	151	4	a	a	DT
cord-001835-0s7ok4uw	151	5	previously	previously	RB
cord-001835-0s7ok4uw	151	6	known	know	VBN
cord-001835-0s7ok4uw	151	7	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	151	8	of	of	IN
cord-001835-0s7ok4uw	151	9	homologous	homologous	JJ
cord-001835-0s7ok4uw	151	10	FabGs	FabGs	NNP
cord-001835-0s7ok4uw	151	11	,	,	,
cord-001835-0s7ok4uw	151	12	was	be	VBD
cord-001835-0s7ok4uw	151	13	tested	test	VBN
cord-001835-0s7ok4uw	151	14	along	along	IN
cord-001835-0s7ok4uw	151	15	with	with	IN
cord-001835-0s7ok4uw	151	16	the	the	DT
cord-001835-0s7ok4uw	151	17	other	other	JJ
cord-001835-0s7ok4uw	151	18	potential	potential	JJ
cord-001835-0s7ok4uw	151	19	drugs	drug	NNS
cord-001835-0s7ok4uw	151	20	,	,	,
cord-001835-0s7ok4uw	151	21	and	and	CC
cord-001835-0s7ok4uw	151	22	was	be	VBD
cord-001835-0s7ok4uw	151	23	determined	determine	VBN
cord-001835-0s7ok4uw	151	24	to	to	TO
cord-001835-0s7ok4uw	151	25	have	have	VB
cord-001835-0s7ok4uw	151	26	moderate	moderate	JJ
cord-001835-0s7ok4uw	151	27	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	151	28	effects	effect	NNS
cord-001835-0s7ok4uw	151	29	on	on	IN
cord-001835-0s7ok4uw	151	30	RpFabG.	RpFabG.	NNP
cord-001835-0s7ok4uw	151	31	Loop	Loop	NNP
cord-001835-0s7ok4uw	151	32	modeling	modeling	NN
cord-001835-0s7ok4uw	151	33	using	use	VBG
cord-001835-0s7ok4uw	151	34	ICM	ICM	NNP
cord-001835-0s7ok4uw	151	35	software	software	NN
cord-001835-0s7ok4uw	151	36	was	be	VBD
cord-001835-0s7ok4uw	151	37	performed	perform	VBN
cord-001835-0s7ok4uw	151	38	in	in	IN
cord-001835-0s7ok4uw	151	39	order	order	NN
cord-001835-0s7ok4uw	151	40	to	to	TO
cord-001835-0s7ok4uw	151	41	create	create	VB
cord-001835-0s7ok4uw	151	42	a	a	DT
cord-001835-0s7ok4uw	151	43	prediction	prediction	NN
cord-001835-0s7ok4uw	151	44	of	of	IN
cord-001835-0s7ok4uw	151	45	the	the	DT
cord-001835-0s7ok4uw	151	46	complete	complete	JJ
cord-001835-0s7ok4uw	151	47	RpFabG	RpFabG	NNP
cord-001835-0s7ok4uw	151	48	structure	structure	NN
cord-001835-0s7ok4uw	151	49	,	,	,
cord-001835-0s7ok4uw	151	50	including	include	VBG
cord-001835-0s7ok4uw	151	51	the	the	DT
cord-001835-0s7ok4uw	151	52	disordered	disordered	JJ
cord-001835-0s7ok4uw	151	53	loops	loop	NNS
cord-001835-0s7ok4uw	151	54	that	that	WDT
cord-001835-0s7ok4uw	151	55	are	be	VBP
cord-001835-0s7ok4uw	151	56	not	not	RB
cord-001835-0s7ok4uw	151	57	a	a	DT
cord-001835-0s7ok4uw	151	58	part	part	NN
cord-001835-0s7ok4uw	151	59	of	of	IN
cord-001835-0s7ok4uw	151	60	the	the	DT
cord-001835-0s7ok4uw	151	61	3F9I	3f9i	CD
cord-001835-0s7ok4uw	151	62	PDB	PDB	NNP
cord-001835-0s7ok4uw	151	63	structure	structure	NN
cord-001835-0s7ok4uw	151	64	.	.	.
cord-001835-0s7ok4uw	152	1	Co	co	NN
cord-001835-0s7ok4uw	152	2	-	-	NN
cord-001835-0s7ok4uw	152	3	crystallization	crystallization	NN
cord-001835-0s7ok4uw	152	4	of	of	IN
cord-001835-0s7ok4uw	152	5	RpFabG	RpFabG	NNPS
cord-001835-0s7ok4uw	152	6	with	with	IN
cord-001835-0s7ok4uw	152	7	both	both	DT
cord-001835-0s7ok4uw	152	8	substrates	substrate	NNS
cord-001835-0s7ok4uw	152	9	was	be	VBD
cord-001835-0s7ok4uw	152	10	carried	carry	VBN
cord-001835-0s7ok4uw	152	11	out	out	RP
cord-001835-0s7ok4uw	152	12	in	in	IN
cord-001835-0s7ok4uw	152	13	order	order	NN
cord-001835-0s7ok4uw	152	14	to	to	TO
cord-001835-0s7ok4uw	152	15	obtain	obtain	VB
cord-001835-0s7ok4uw	152	16	a	a	DT
cord-001835-0s7ok4uw	152	17	structure	structure	NN
cord-001835-0s7ok4uw	152	18	,	,	,
cord-001835-0s7ok4uw	152	19	but	but	CC
cord-001835-0s7ok4uw	152	20	only	only	RB
cord-001835-0s7ok4uw	152	21	nondiffracting	nondiffracte	VBG
cord-001835-0s7ok4uw	152	22	crystals	crystal	NNS
cord-001835-0s7ok4uw	152	23	resulted	result	VBD
cord-001835-0s7ok4uw	152	24	.	.	.
cord-001835-0s7ok4uw	153	1	Further	further	JJ
cord-001835-0s7ok4uw	153	2	inhibition	inhibition	NN
cord-001835-0s7ok4uw	153	3	assays	assay	NNS
cord-001835-0s7ok4uw	153	4	and	and	CC
cord-001835-0s7ok4uw	153	5	crystallography	crystallography	NN
cord-001835-0s7ok4uw	153	6	trials	trial	NNS
cord-001835-0s7ok4uw	153	7	are	be	VBP
cord-001835-0s7ok4uw	153	8	being	be	VBG
cord-001835-0s7ok4uw	153	9	performed	perform	VBN
cord-001835-0s7ok4uw	153	10	in	in	IN
cord-001835-0s7ok4uw	153	11	order	order	NN
cord-001835-0s7ok4uw	153	12	to	to	TO
cord-001835-0s7ok4uw	153	13	continue	continue	VB
cord-001835-0s7ok4uw	153	14	the	the	DT
cord-001835-0s7ok4uw	153	15	search	search	NN
cord-001835-0s7ok4uw	153	16	for	for	IN
cord-001835-0s7ok4uw	153	17	a	a	DT
cord-001835-0s7ok4uw	153	18	novel	novel	JJ
cord-001835-0s7ok4uw	153	19	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	153	20	of	of	IN
cord-001835-0s7ok4uw	153	21	RpFabG	RpFabG	NNPS
cord-001835-0s7ok4uw	153	22	and	and	CC
cord-001835-0s7ok4uw	153	23	ultimately	ultimately	RB
cord-001835-0s7ok4uw	153	24	a	a	DT
cord-001835-0s7ok4uw	153	25	treatment	treatment	NN
cord-001835-0s7ok4uw	153	26	for	for	IN
cord-001835-0s7ok4uw	153	27	epidemic	epidemic	NN
cord-001835-0s7ok4uw	153	28	typhus	typhus	NN
cord-001835-0s7ok4uw	153	29	.	.	.
cord-001835-0s7ok4uw	154	1	1	1	LS
cord-001835-0s7ok4uw	155	1	The	the	DT
cord-001835-0s7ok4uw	155	2	University	University	NNP
cord-001835-0s7ok4uw	155	3	of	of	IN
cord-001835-0s7ok4uw	155	4	Hong	Hong	NNP
cord-001835-0s7ok4uw	155	5	Kong	Kong	NNP
cord-001835-0s7ok4uw	155	6	Bioconjugation	Bioconjugation	NNP
cord-001835-0s7ok4uw	155	7	of	of	IN
cord-001835-0s7ok4uw	155	8	proteins	protein	NNS
cord-001835-0s7ok4uw	155	9	has	have	VBZ
cord-001835-0s7ok4uw	155	10	emerged	emerge	VBN
cord-001835-0s7ok4uw	155	11	as	as	IN
cord-001835-0s7ok4uw	155	12	a	a	DT
cord-001835-0s7ok4uw	155	13	useful	useful	JJ
cord-001835-0s7ok4uw	155	14	tool	tool	NN
cord-001835-0s7ok4uw	155	15	in	in	IN
cord-001835-0s7ok4uw	155	16	the	the	DT
cord-001835-0s7ok4uw	155	17	study	study	NN
cord-001835-0s7ok4uw	155	18	of	of	IN
cord-001835-0s7ok4uw	155	19	biological	biological	JJ
cord-001835-0s7ok4uw	155	20	systems	system	NNS
cord-001835-0s7ok4uw	155	21	.	.	.
cord-001835-0s7ok4uw	156	1	There	there	EX
cord-001835-0s7ok4uw	156	2	is	be	VBZ
cord-001835-0s7ok4uw	156	3	an	an	DT
cord-001835-0s7ok4uw	156	4	increasing	increase	VBG
cord-001835-0s7ok4uw	156	5	need	need	NN
cord-001835-0s7ok4uw	156	6	to	to	TO
cord-001835-0s7ok4uw	156	7	develop	develop	VB
cord-001835-0s7ok4uw	156	8	new	new	JJ
cord-001835-0s7ok4uw	156	9	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	156	10	technologies	technology	NNS
cord-001835-0s7ok4uw	156	11	for	for	IN
cord-001835-0s7ok4uw	156	12	the	the	DT
cord-001835-0s7ok4uw	156	13	bioconjugation	bioconjugation	NN
cord-001835-0s7ok4uw	156	14	reaction	reaction	NN
cord-001835-0s7ok4uw	156	15	of	of	IN
cord-001835-0s7ok4uw	156	16	proteins	protein	NNS
cord-001835-0s7ok4uw	156	17	,	,	,
cord-001835-0s7ok4uw	156	18	and	and	CC
cord-001835-0s7ok4uw	156	19	metal	metal	NN
cord-001835-0s7ok4uw	156	20	-	-	HYPH
cord-001835-0s7ok4uw	156	21	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	156	22	site	site	NN
cord-001835-0s7ok4uw	156	23	-	-	HYPH
cord-001835-0s7ok4uw	156	24	selective	selective	JJ
cord-001835-0s7ok4uw	156	25	modification	modification	NN
cord-001835-0s7ok4uw	156	26	of	of	IN
cord-001835-0s7ok4uw	156	27	proteins	protein	NNS
cord-001835-0s7ok4uw	156	28	has	have	VBZ
cord-001835-0s7ok4uw	156	29	attracted	attract	VBN
cord-001835-0s7ok4uw	156	30	considerable	considerable	JJ
cord-001835-0s7ok4uw	156	31	interest	interest	NN
cord-001835-0s7ok4uw	156	32	in	in	IN
cord-001835-0s7ok4uw	156	33	recent	recent	JJ
cord-001835-0s7ok4uw	156	34	years	year	NNS
cord-001835-0s7ok4uw	156	35	.	.	.
cord-001835-0s7ok4uw	157	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	157	2	have	have	VBP
cord-001835-0s7ok4uw	157	3	developed	develop	VBN
cord-001835-0s7ok4uw	157	4	a	a	DT
cord-001835-0s7ok4uw	157	5	ruthenium	ruthenium	JJ
cord-001835-0s7ok4uw	157	6	glycosylated	glycosylated	JJ
cord-001835-0s7ok4uw	157	7	porphyrin	porphyrin	NN
cord-001835-0s7ok4uw	157	8	-	-	HYPH
cord-001835-0s7ok4uw	157	9	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	157	10	carbenoid	carbenoid	NN
cord-001835-0s7ok4uw	157	11	transfer	transfer	NN
cord-001835-0s7ok4uw	157	12	reaction	reaction	NN
cord-001835-0s7ok4uw	157	13	for	for	IN
cord-001835-0s7ok4uw	157	14	the	the	DT
cord-001835-0s7ok4uw	157	15	site	site	NN
cord-001835-0s7ok4uw	157	16	-	-	HYPH
cord-001835-0s7ok4uw	157	17	selective	selective	JJ
cord-001835-0s7ok4uw	157	18	modification	modification	NN
cord-001835-0s7ok4uw	157	19	of	of	IN
cord-001835-0s7ok4uw	157	20	proteins	protein	NNS
cord-001835-0s7ok4uw	157	21	.	.	.
cord-001835-0s7ok4uw	158	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	158	2	firstly	firstly	RB
cord-001835-0s7ok4uw	158	3	applied	apply	VBD
cord-001835-0s7ok4uw	158	4	the	the	DT
cord-001835-0s7ok4uw	158	5	catalysis	catalysis	NN
cord-001835-0s7ok4uw	158	6	to	to	IN
cord-001835-0s7ok4uw	158	7	the	the	DT
cord-001835-0s7ok4uw	158	8	selective	selective	JJ
cord-001835-0s7ok4uw	158	9	modification	modification	NN
cord-001835-0s7ok4uw	158	10	of	of	IN
cord-001835-0s7ok4uw	158	11	the	the	DT
cord-001835-0s7ok4uw	158	12	N	n	CD
cord-001835-0s7ok4uw	158	13	-	-	HYPH
cord-001835-0s7ok4uw	158	14	terminus	terminus	NN
cord-001835-0s7ok4uw	158	15	of	of	IN
cord-001835-0s7ok4uw	158	16	peptides	peptide	NNS
cord-001835-0s7ok4uw	158	17	.	.	.
cord-001835-0s7ok4uw	159	1	By	by	IN
cord-001835-0s7ok4uw	159	2	using	use	VBG
cord-001835-0s7ok4uw	159	3	ruthenium	ruthenium	NN
cord-001835-0s7ok4uw	159	4	glycosylated	glycosylated	JJ
cord-001835-0s7ok4uw	159	5	porphyrin	porphyrin	NN
cord-001835-0s7ok4uw	159	6	as	as	IN
cord-001835-0s7ok4uw	159	7	catalyst	catalyst	NN
cord-001835-0s7ok4uw	159	8	,	,	,
cord-001835-0s7ok4uw	159	9	the	the	DT
cord-001835-0s7ok4uw	159	10	N	n	CD
cord-001835-0s7ok4uw	159	11	-	-	HYPH
cord-001835-0s7ok4uw	159	12	terminus	terminus	NN
cord-001835-0s7ok4uw	159	13	of	of	IN
cord-001835-0s7ok4uw	159	14	a	a	DT
cord-001835-0s7ok4uw	159	15	number	number	NN
cord-001835-0s7ok4uw	159	16	of	of	IN
cord-001835-0s7ok4uw	159	17	peptides	peptide	NNS
cord-001835-0s7ok4uw	159	18	can	can	MD
cord-001835-0s7ok4uw	159	19	be	be	VB
cord-001835-0s7ok4uw	159	20	modified	modify	VBN
cord-001835-0s7ok4uw	159	21	through	through	IN
cord-001835-0s7ok4uw	159	22	carbenoid	carbenoid	NNP
cord-001835-0s7ok4uw	159	23	N	N	NNP
cord-001835-0s7ok4uw	159	24	-	-	HYPH
cord-001835-0s7ok4uw	159	25	H	H	NNP
cord-001835-0s7ok4uw	159	26	bond	bond	NN
cord-001835-0s7ok4uw	159	27	insertion	insertion	NN
cord-001835-0s7ok4uw	159	28	in	in	IN
cord-001835-0s7ok4uw	159	29	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	159	30	media	medium	NNS
cord-001835-0s7ok4uw	159	31	with	with	IN
cord-001835-0s7ok4uw	159	32	moderate	moderate	JJ
cord-001835-0s7ok4uw	159	33	to	to	IN
cord-001835-0s7ok4uw	159	34	excellent	excellent	JJ
cord-001835-0s7ok4uw	159	35	conversion	conversion	NN
cord-001835-0s7ok4uw	159	36	.	.	.
cord-001835-0s7ok4uw	160	1	The	the	DT
cord-001835-0s7ok4uw	160	2	reaction	reaction	NN
cord-001835-0s7ok4uw	160	3	is	be	VBZ
cord-001835-0s7ok4uw	160	4	highly	highly	RB
cord-001835-0s7ok4uw	160	5	selective	selective	JJ
cord-001835-0s7ok4uw	160	6	,	,	,
cord-001835-0s7ok4uw	160	7	for	for	IN
cord-001835-0s7ok4uw	160	8	example	example	NN
cord-001835-0s7ok4uw	160	9	,	,	,
cord-001835-0s7ok4uw	160	10	the	the	DT
cord-001835-0s7ok4uw	160	11	reaction	reaction	NN
cord-001835-0s7ok4uw	160	12	with	with	IN
cord-001835-0s7ok4uw	160	13	YTSSSKNVVR	YTSSSKNVVR	NNP
cord-001835-0s7ok4uw	160	14	,	,	,
cord-001835-0s7ok4uw	160	15	which	which	WDT
cord-001835-0s7ok4uw	160	16	contains	contain	VBZ
cord-001835-0s7ok4uw	160	17	various	various	JJ
cord-001835-0s7ok4uw	160	18	types	type	NNS
cord-001835-0s7ok4uw	160	19	of	of	IN
cord-001835-0s7ok4uw	160	20	oxygenhydrogen	oxygenhydrogen	NNP
cord-001835-0s7ok4uw	160	21	and	and	CC
cord-001835-0s7ok4uw	160	22	nitrogen	nitrogen	NN
cord-001835-0s7ok4uw	160	23	-	-	HYPH
cord-001835-0s7ok4uw	160	24	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	160	25	bonds	bond	NNS
cord-001835-0s7ok4uw	160	26	possibly	possibly	RB
cord-001835-0s7ok4uw	160	27	available	available	JJ
cord-001835-0s7ok4uw	160	28	for	for	IN
cord-001835-0s7ok4uw	160	29	carbenoid	carbenoid	JJ
cord-001835-0s7ok4uw	160	30	insertion	insertion	NN
cord-001835-0s7ok4uw	160	31	,	,	,
cord-001835-0s7ok4uw	160	32	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	160	33	by	by	IN
cord-001835-0s7ok4uw	160	34	the	the	DT
cord-001835-0s7ok4uw	160	35	ruthenium	ruthenium	NN
cord-001835-0s7ok4uw	160	36	glycosylated	glycosylated	JJ
cord-001835-0s7ok4uw	160	37	porphyrin	porphyrin	NN
cord-001835-0s7ok4uw	160	38	gave	give	VBD
cord-001835-0s7ok4uw	160	39	the	the	DT
cord-001835-0s7ok4uw	160	40	N	n	CD
cord-001835-0s7ok4uw	160	41	-	-	HYPH
cord-001835-0s7ok4uw	160	42	terminal	terminal	NN
cord-001835-0s7ok4uw	160	43	-	-	HYPH
cord-001835-0s7ok4uw	160	44	modified	modify	VBN
cord-001835-0s7ok4uw	160	45	product	product	NN
cord-001835-0s7ok4uw	160	46	with	with	IN
cord-001835-0s7ok4uw	160	47	>	>	$
cord-001835-0s7ok4uw	160	48	99	99	CD
cord-001835-0s7ok4uw	160	49	%	%	NN
cord-001835-0s7ok4uw	160	50	conversion	conversion	NN
cord-001835-0s7ok4uw	160	51	and	and	CC
cord-001835-0s7ok4uw	160	52	without	without	IN
cord-001835-0s7ok4uw	160	53	the	the	DT
cord-001835-0s7ok4uw	160	54	formation	formation	NN
cord-001835-0s7ok4uw	160	55	of	of	IN
cord-001835-0s7ok4uw	160	56	other	other	JJ
cord-001835-0s7ok4uw	160	57	modified	modify	VBN
cord-001835-0s7ok4uw	160	58	peptides	peptide	NNS
cord-001835-0s7ok4uw	160	59	including	include	VBG
cord-001835-0s7ok4uw	160	60	doubly	doubly	RB
cord-001835-0s7ok4uw	160	61	modified	modify	VBN
cord-001835-0s7ok4uw	160	62	and	and	CC
cord-001835-0s7ok4uw	160	63	oxygenhydrogen	oxygenhydrogen	NNP
cord-001835-0s7ok4uw	160	64	bond	bond	NN
cord-001835-0s7ok4uw	160	65	insertion	insertion	NN
cord-001835-0s7ok4uw	160	66	products	product	NNS
cord-001835-0s7ok4uw	160	67	.	.	.
cord-001835-0s7ok4uw	161	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	161	2	next	next	RB
cord-001835-0s7ok4uw	161	3	extended	extend	VBD
cord-001835-0s7ok4uw	161	4	the	the	DT
cord-001835-0s7ok4uw	161	5	N	n	CD
cord-001835-0s7ok4uw	161	6	-	-	HYPH
cord-001835-0s7ok4uw	161	7	terminal	terminal	JJ
cord-001835-0s7ok4uw	161	8	modification	modification	NN
cord-001835-0s7ok4uw	161	9	method	method	NN
cord-001835-0s7ok4uw	161	10	to	to	IN
cord-001835-0s7ok4uw	161	11	proteins	protein	NNS
cord-001835-0s7ok4uw	161	12	.	.	.
cord-001835-0s7ok4uw	162	1	Eventually	eventually	RB
cord-001835-0s7ok4uw	162	2	success	success	NN
cord-001835-0s7ok4uw	162	3	was	be	VBD
cord-001835-0s7ok4uw	162	4	attained	attain	VBN
cord-001835-0s7ok4uw	162	5	in	in	IN
cord-001835-0s7ok4uw	162	6	the	the	DT
cord-001835-0s7ok4uw	162	7	modification	modification	NN
cord-001835-0s7ok4uw	162	8	of	of	IN
cord-001835-0s7ok4uw	162	9	RNase	RNase	NNP
cord-001835-0s7ok4uw	162	10	A	A	NNP
cord-001835-0s7ok4uw	162	11	and	and	CC
cord-001835-0s7ok4uw	162	12	insulin	insulin	NN
cord-001835-0s7ok4uw	162	13	.	.	.
cord-001835-0s7ok4uw	163	1	The	the	DT
cord-001835-0s7ok4uw	163	2	reaction	reaction	NN
cord-001835-0s7ok4uw	163	3	of	of	IN
cord-001835-0s7ok4uw	163	4	RNase	RNase	NNP
cord-001835-0s7ok4uw	163	5	A	A	NNP
cord-001835-0s7ok4uw	163	6	with	with	IN
cord-001835-0s7ok4uw	163	7	a	a	DT
cord-001835-0s7ok4uw	163	8	diazoacetate	diazoacetate	NN
cord-001835-0s7ok4uw	163	9	mediated	mediate	VBN
cord-001835-0s7ok4uw	163	10	by	by	IN
cord-001835-0s7ok4uw	163	11	ruthenium	ruthenium	JJ
cord-001835-0s7ok4uw	163	12	glycosylated	glycosylated	JJ
cord-001835-0s7ok4uw	163	13	porphyrin	porphyrin	NN
cord-001835-0s7ok4uw	163	14	gave	give	VBD
cord-001835-0s7ok4uw	163	15	corresponding	correspond	VBG
cord-001835-0s7ok4uw	163	16	N	n	CD
cord-001835-0s7ok4uw	163	17	-	-	HYPH
cord-001835-0s7ok4uw	163	18	terminal	terminal	NN
cord-001835-0s7ok4uw	163	19	-	-	HYPH
cord-001835-0s7ok4uw	163	20	modified	modify	VBN
cord-001835-0s7ok4uw	163	21	protein	protein	NN
cord-001835-0s7ok4uw	163	22	with	with	IN
cord-001835-0s7ok4uw	163	23	65	65	CD
cord-001835-0s7ok4uw	163	24	%	%	NN
cord-001835-0s7ok4uw	163	25	conversion	conversion	NN
cord-001835-0s7ok4uw	163	26	.	.	.
cord-001835-0s7ok4uw	164	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	164	2	also	also	RB
cord-001835-0s7ok4uw	164	3	achieved	achieve	VBD
cord-001835-0s7ok4uw	164	4	a	a	DT
cord-001835-0s7ok4uw	164	5	bioconjugation	bioconjugation	NN
cord-001835-0s7ok4uw	164	6	to	to	TO
cord-001835-0s7ok4uw	164	7	ubiquitin	ubiquitin	VB
cord-001835-0s7ok4uw	164	8	via	via	IN
cord-001835-0s7ok4uw	164	9	ruthenium	ruthenium	JJ
cord-001835-0s7ok4uw	164	10	glycosylated	glycosylated	JJ
cord-001835-0s7ok4uw	164	11	porphyrin	porphyrin	NN
cord-001835-0s7ok4uw	164	12	-	-	HYPH
cord-001835-0s7ok4uw	164	13	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	164	14	alkene	alkene	NN
cord-001835-0s7ok4uw	164	15	cyclopropanation	cyclopropanation	NN
cord-001835-0s7ok4uw	164	16	in	in	IN
cord-001835-0s7ok4uw	164	17	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	164	18	solution	solution	NN
cord-001835-0s7ok4uw	164	19	in	in	IN
cord-001835-0s7ok4uw	164	20	two	two	CD
cord-001835-0s7ok4uw	164	21	steps	step	NNS
cord-001835-0s7ok4uw	164	22	:	:	:
cord-001835-0s7ok4uw	164	23	(	(	-LRB-
cord-001835-0s7ok4uw	164	24	1	1	LS
cord-001835-0s7ok4uw	164	25	)	)	-RRB-
cord-001835-0s7ok4uw	164	26	incorporation	incorporation	NN
cord-001835-0s7ok4uw	164	27	of	of	IN
cord-001835-0s7ok4uw	164	28	an	an	DT
cord-001835-0s7ok4uw	164	29	alkenic	alkenic	NNP
cord-001835-0s7ok4uw	164	30	group	group	NN
cord-001835-0s7ok4uw	164	31	by	by	IN
cord-001835-0s7ok4uw	164	32	the	the	DT
cord-001835-0s7ok4uw	164	33	reaction	reaction	NN
cord-001835-0s7ok4uw	164	34	of	of	IN
cord-001835-0s7ok4uw	164	35	N	n	CD
cord-001835-0s7ok4uw	164	36	-	-	HYPH
cord-001835-0s7ok4uw	164	37	hydroxysuccinimide	hydroxysuccinimide	NN
cord-001835-0s7ok4uw	164	38	ester	ester	NN
cord-001835-0s7ok4uw	164	39	with	with	IN
cord-001835-0s7ok4uw	164	40	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	164	41	and	and	CC
cord-001835-0s7ok4uw	164	42	(	(	-LRB-
cord-001835-0s7ok4uw	164	43	2	2	LS
cord-001835-0s7ok4uw	164	44	)	)	-RRB-
cord-001835-0s7ok4uw	164	45	cyclopropanation	cyclopropanation	NN
cord-001835-0s7ok4uw	164	46	of	of	IN
cord-001835-0s7ok4uw	164	47	the	the	DT
cord-001835-0s7ok4uw	164	48	alkene	alkene	NN
cord-001835-0s7ok4uw	164	49	-	-	HYPH
cord-001835-0s7ok4uw	164	50	tethered	tether	VBN
cord-001835-0s7ok4uw	164	51	Lys6	Lys6	NNP
cord-001835-0s7ok4uw	164	52	ubiquitin	ubiquitin	VB
cord-001835-0s7ok4uw	164	53	with	with	IN
cord-001835-0s7ok4uw	164	54	the	the	DT
cord-001835-0s7ok4uw	164	55	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	164	56	labeled	label	VBN
cord-001835-0s7ok4uw	164	57	diazoacetate	diazoacetate	NN
cord-001835-0s7ok4uw	164	58	in	in	IN
cord-001835-0s7ok4uw	164	59	the	the	DT
cord-001835-0s7ok4uw	164	60	presence	presence	NN
cord-001835-0s7ok4uw	164	61	of	of	IN
cord-001835-0s7ok4uw	164	62	a	a	DT
cord-001835-0s7ok4uw	164	63	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	164	64	amount	amount	NN
cord-001835-0s7ok4uw	164	65	of	of	IN
cord-001835-0s7ok4uw	164	66	ruthenium	ruthenium	JJ
cord-001835-0s7ok4uw	164	67	glycosylated	glycosylated	JJ
cord-001835-0s7ok4uw	164	68	porphyrin	porphyrin	NN
cord-001835-0s7ok4uw	164	69	.	.	.
cord-001835-0s7ok4uw	165	1	The	the	DT
cord-001835-0s7ok4uw	165	2	corresponding	correspond	VBG
cord-001835-0s7ok4uw	165	3	cyclopropanation	cyclopropanation	NN
cord-001835-0s7ok4uw	165	4	product	product	NN
cord-001835-0s7ok4uw	165	5	was	be	VBD
cord-001835-0s7ok4uw	165	6	obtained	obtain	VBN
cord-001835-0s7ok4uw	165	7	with	with	IN
cord-001835-0s7ok4uw	165	8	55	55	CD
cord-001835-0s7ok4uw	165	9	%	%	NN
cord-001835-0s7ok4uw	165	10	conversion	conversion	NN
cord-001835-0s7ok4uw	165	11	based	base	VBN
cord-001835-0s7ok4uw	165	12	on	on	IN
cord-001835-0s7ok4uw	165	13	MALDI	MALDI	NNP
cord-001835-0s7ok4uw	165	14	-	-	HYPH
cord-001835-0s7ok4uw	165	15	TOF	TOF	NNP
cord-001835-0s7ok4uw	165	16	mass	mass	NN
cord-001835-0s7ok4uw	165	17	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	165	18	.	.	.
cord-001835-0s7ok4uw	166	1	In	in	IN
cord-001835-0s7ok4uw	166	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	166	3	,	,	,
cord-001835-0s7ok4uw	166	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	166	5	developed	develop	VBD
cord-001835-0s7ok4uw	166	6	a	a	DT
cord-001835-0s7ok4uw	166	7	ruthenium	ruthenium	NN
cord-001835-0s7ok4uw	166	8	porphyrin	porphyrin	NN
cord-001835-0s7ok4uw	166	9	-	-	HYPH
cord-001835-0s7ok4uw	166	10	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	166	11	siteselective	siteselective	JJ
cord-001835-0s7ok4uw	166	12	modification	modification	NN
cord-001835-0s7ok4uw	166	13	of	of	IN
cord-001835-0s7ok4uw	166	14	peptides	peptide	NNS
cord-001835-0s7ok4uw	166	15	and	and	CC
cord-001835-0s7ok4uw	166	16	proteins	protein	NNS
cord-001835-0s7ok4uw	166	17	in	in	IN
cord-001835-0s7ok4uw	166	18	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	166	19	media	medium	NNS
cord-001835-0s7ok4uw	166	20	.	.	.
cord-001835-0s7ok4uw	167	1	The	the	DT
cord-001835-0s7ok4uw	167	2	method	method	NN
cord-001835-0s7ok4uw	167	3	provides	provide	VBZ
cord-001835-0s7ok4uw	167	4	an	an	DT
cord-001835-0s7ok4uw	167	5	entry	entry	NN
cord-001835-0s7ok4uw	167	6	to	to	IN
cord-001835-0s7ok4uw	167	7	new	new	JJ
cord-001835-0s7ok4uw	167	8	bioconjugation	bioconjugation	NN
cord-001835-0s7ok4uw	167	9	reactions	reaction	NNS
cord-001835-0s7ok4uw	167	10	for	for	IN
cord-001835-0s7ok4uw	167	11	protein	protein	NN
cord-001835-0s7ok4uw	167	12	modifications	modification	NNS
cord-001835-0s7ok4uw	167	13	using	use	VBG
cord-001835-0s7ok4uw	167	14	metalloporphyrins	metalloporphyrin	NNS
cord-001835-0s7ok4uw	167	15	as	as	IN
cord-001835-0s7ok4uw	167	16	catalysts	catalyst	NNS
cord-001835-0s7ok4uw	167	17	.	.	.
cord-001835-0s7ok4uw	168	1	Uridine	Uridine	NNP
cord-001835-0s7ok4uw	168	2	Monophosphate	Monophosphate	NNP
cord-001835-0s7ok4uw	168	3	Synthase	Synthase	NNP
cord-001835-0s7ok4uw	168	4	:	:	:
cord-001835-0s7ok4uw	169	1	Architecture	architecture	NN
cord-001835-0s7ok4uw	169	2	Versatility	versatility	NN
cord-001835-0s7ok4uw	169	3	in	in	IN
cord-001835-0s7ok4uw	169	4	the	the	DT
cord-001835-0s7ok4uw	169	5	Service	Service	NNP
cord-001835-0s7ok4uw	169	6	of	of	IN
cord-001835-0s7ok4uw	169	7	Late	Late	NNP
cord-001835-0s7ok4uw	169	8	Blight	Blight	NNP
cord-001835-0s7ok4uw	169	9	Control	Control	NNP
cord-001835-0s7ok4uw	169	10	Francisco	Francisco	NNP
cord-001835-0s7ok4uw	169	11	Tenjo	Tenjo	NNP
cord-001835-0s7ok4uw	170	1	Castaño	Castaño	NNP
cord-001835-0s7ok4uw	170	2	1,2	1,2	CD
cord-001835-0s7ok4uw	171	1	,	,	,
cord-001835-0s7ok4uw	171	2	Manuel	Manuel	NNP
cord-001835-0s7ok4uw	171	3	Garavito	Garavito	NNP
cord-001835-0s7ok4uw	171	4	1,2	1,2	CD
cord-001835-0s7ok4uw	171	5	,	,	,
cord-001835-0s7ok4uw	171	6	Leonor	Leonor	NNP
cord-001835-0s7ok4uw	171	7	Garc	Garc	NNP
cord-001835-0s7ok4uw	171	8	ıa	ıa	VBZ
cord-001835-0s7ok4uw	171	9	1,2	1,2	CD
cord-001835-0s7ok4uw	171	10	,	,	,
cord-001835-0s7ok4uw	171	11	Silvia	Silvia	NNP
cord-001835-0s7ok4uw	171	12	Restrepo	Restrepo	NNP
cord-001835-0s7ok4uw	171	13	2	2	CD
cord-001835-0s7ok4uw	171	14	,	,	,
cord-001835-0s7ok4uw	171	15	Barbara	Barbara	NNP
cord-001835-0s7ok4uw	171	16	Zimmermann	Zimmermann	NNP
cord-001835-0s7ok4uw	171	17	1	1	CD
cord-001835-0s7ok4uw	171	18	1	1	CD
cord-001835-0s7ok4uw	171	19	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	171	20	and	and	CC
cord-001835-0s7ok4uw	171	21	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	171	22	Biology	Biology	NNP
cord-001835-0s7ok4uw	171	23	Research	Research	NNP
cord-001835-0s7ok4uw	171	24	Group	Group	NNP
cord-001835-0s7ok4uw	171	25	,	,	,
cord-001835-0s7ok4uw	171	26	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	171	27	de	de	IN
cord-001835-0s7ok4uw	171	28	los	los	NNP
cord-001835-0s7ok4uw	171	29	Andes	Andes	NNP
cord-001835-0s7ok4uw	171	30	.	.	NNP
cord-001835-0s7ok4uw	171	31	,	,	,
cord-001835-0s7ok4uw	171	32	2	2	CD
cord-001835-0s7ok4uw	171	33	Mycology	mycology	NN
cord-001835-0s7ok4uw	171	34	and	and	CC
cord-001835-0s7ok4uw	171	35	Plan	Plan	NNP
cord-001835-0s7ok4uw	171	36	Pathology	Pathology	NNP
cord-001835-0s7ok4uw	171	37	Laboratory	Laboratory	NNP
cord-001835-0s7ok4uw	171	38	,	,	,
cord-001835-0s7ok4uw	171	39	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	171	40	de	de	IN
cord-001835-0s7ok4uw	171	41	los	los	NNP
cord-001835-0s7ok4uw	171	42	Andes	Andes	NNP
cord-001835-0s7ok4uw	171	43	Uridine	Uridine	NNP
cord-001835-0s7ok4uw	171	44	monophosphate	monophosphate	NN
cord-001835-0s7ok4uw	171	45	synthase	synthase	NN
cord-001835-0s7ok4uw	171	46	(	(	-LRB-
cord-001835-0s7ok4uw	171	47	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	171	48	)	)	-RRB-
cord-001835-0s7ok4uw	171	49	,	,	,
cord-001835-0s7ok4uw	171	50	a	a	DT
cord-001835-0s7ok4uw	171	51	bifunctional	bifunctional	JJ
cord-001835-0s7ok4uw	171	52	enzyme	enzyme	NN
cord-001835-0s7ok4uw	171	53	in	in	IN
cord-001835-0s7ok4uw	171	54	the	the	DT
cord-001835-0s7ok4uw	171	55	de	de	FW
cord-001835-0s7ok4uw	171	56	novo	novo	NNP
cord-001835-0s7ok4uw	171	57	pyrimidine	pyrimidine	NNP
cord-001835-0s7ok4uw	171	58	biosynthetic	biosynthetic	JJ
cord-001835-0s7ok4uw	171	59	pathway	pathway	NN
cord-001835-0s7ok4uw	171	60	,	,	,
cord-001835-0s7ok4uw	171	61	is	be	VBZ
cord-001835-0s7ok4uw	171	62	a	a	DT
cord-001835-0s7ok4uw	171	63	protein	protein	NN
cord-001835-0s7ok4uw	171	64	comprised	comprise	VBN
cord-001835-0s7ok4uw	171	65	of	of	IN
cord-001835-0s7ok4uw	171	66	orotate	orotate	NNP
cord-001835-0s7ok4uw	171	67	phosphoribosyl	phosphoribosyl	NNP
cord-001835-0s7ok4uw	171	68	transferase	transferase	NNP
cord-001835-0s7ok4uw	171	69	(	(	-LRB-
cord-001835-0s7ok4uw	171	70	OPRTase	OPRTase	NNP
cord-001835-0s7ok4uw	171	71	)	)	-RRB-
cord-001835-0s7ok4uw	171	72	and	and	CC
cord-001835-0s7ok4uw	171	73	orotidine	orotidine	JJ
cord-001835-0s7ok4uw	171	74	monophosphate	monophosphate	NN
cord-001835-0s7ok4uw	171	75	decarboxylase	decarboxylase	NN
cord-001835-0s7ok4uw	172	1	(	(	-LRB-
cord-001835-0s7ok4uw	172	2	ODCase	ODCase	NNP
cord-001835-0s7ok4uw	172	3	)	)	-RRB-
cord-001835-0s7ok4uw	172	4	.	.	.
cord-001835-0s7ok4uw	173	1	Different	different	JJ
cord-001835-0s7ok4uw	173	2	fusion	fusion	NN
cord-001835-0s7ok4uw	173	3	orders	order	NNS
cord-001835-0s7ok4uw	173	4	of	of	IN
cord-001835-0s7ok4uw	173	5	the	the	DT
cord-001835-0s7ok4uw	173	6	two	two	CD
cord-001835-0s7ok4uw	173	7	domains	domain	NNS
cord-001835-0s7ok4uw	173	8	have	have	VBP
cord-001835-0s7ok4uw	173	9	been	be	VBN
cord-001835-0s7ok4uw	173	10	documented	document	VBN
cord-001835-0s7ok4uw	173	11	to	to	TO
cord-001835-0s7ok4uw	173	12	exist	exist	VB
cord-001835-0s7ok4uw	173	13	in	in	IN
cord-001835-0s7ok4uw	173	14	nature	nature	NN
cord-001835-0s7ok4uw	173	15	.	.	.
cord-001835-0s7ok4uw	174	1	In	in	IN
cord-001835-0s7ok4uw	174	2	some	some	DT
cord-001835-0s7ok4uw	174	3	organisms	organism	NNS
cord-001835-0s7ok4uw	174	4	OPRTase	oprtase	NN
cord-001835-0s7ok4uw	175	1	and	and	CC
cord-001835-0s7ok4uw	175	2	ODCase	ODCase	NNP
cord-001835-0s7ok4uw	175	3	are	be	VBP
cord-001835-0s7ok4uw	175	4	monofunctional	monofunctional	JJ
cord-001835-0s7ok4uw	175	5	proteins	protein	NNS
cord-001835-0s7ok4uw	175	6	,	,	,
cord-001835-0s7ok4uw	175	7	and	and	CC
cord-001835-0s7ok4uw	175	8	act	act	VB
cord-001835-0s7ok4uw	175	9	as	as	IN
cord-001835-0s7ok4uw	175	10	a	a	DT
cord-001835-0s7ok4uw	175	11	complex	complex	NN
cord-001835-0s7ok4uw	175	12	.	.	.
cord-001835-0s7ok4uw	176	1	Here	here	RB
cord-001835-0s7ok4uw	176	2	,	,	,
cord-001835-0s7ok4uw	176	3	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	176	4	from	from	IN
cord-001835-0s7ok4uw	176	5	Solanum	Solanum	NNP
cord-001835-0s7ok4uw	176	6	tuberosum	tuberosum	NN
cord-001835-0s7ok4uw	176	7	(	(	-LRB-
cord-001835-0s7ok4uw	176	8	potato	potato	NN
cord-001835-0s7ok4uw	176	9	)	)	-RRB-
cord-001835-0s7ok4uw	176	10	and	and	CC
cord-001835-0s7ok4uw	176	11	from	from	IN
cord-001835-0s7ok4uw	176	12	Phytophthora	Phytophthora	NNP
cord-001835-0s7ok4uw	176	13	infestans	infestan	NNS
cord-001835-0s7ok4uw	176	14	(	(	-LRB-
cord-001835-0s7ok4uw	176	15	an	an	DT
cord-001835-0s7ok4uw	176	16	oomycete	oomycete	NN
cord-001835-0s7ok4uw	176	17	)	)	-RRB-
cord-001835-0s7ok4uw	176	18	were	be	VBD
cord-001835-0s7ok4uw	176	19	examined	examine	VBN
cord-001835-0s7ok4uw	176	20	.	.	.
cord-001835-0s7ok4uw	177	1	P.	P.	NNP
cord-001835-0s7ok4uw	177	2	infestans	infestan	NNS
cord-001835-0s7ok4uw	177	3	causes	cause	VBZ
cord-001835-0s7ok4uw	177	4	late	late	JJ
cord-001835-0s7ok4uw	177	5	blight	blight	NN
cord-001835-0s7ok4uw	177	6	disease	disease	NN
cord-001835-0s7ok4uw	177	7	in	in	IN
cord-001835-0s7ok4uw	177	8	S.	S.	NNP
cord-001835-0s7ok4uw	177	9	tuberosum	tuberosum	NN
cord-001835-0s7ok4uw	177	10	,	,	,
cord-001835-0s7ok4uw	177	11	destroying	destroy	VBG
cord-001835-0s7ok4uw	177	12	crops	crop	NNS
cord-001835-0s7ok4uw	177	13	and	and	CC
cord-001835-0s7ok4uw	177	14	increasing	increase	VBG
cord-001835-0s7ok4uw	177	15	production	production	NN
cord-001835-0s7ok4uw	177	16	costs	cost	NNS
cord-001835-0s7ok4uw	177	17	.	.	.
cord-001835-0s7ok4uw	178	1	Since	since	IN
cord-001835-0s7ok4uw	178	2	pyrimidines	pyrimidine	NNS
cord-001835-0s7ok4uw	178	3	are	be	VBP
cord-001835-0s7ok4uw	178	4	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	178	5	cellular	cellular	JJ
cord-001835-0s7ok4uw	178	6	components	component	NNS
cord-001835-0s7ok4uw	178	7	,	,	,
cord-001835-0s7ok4uw	178	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	178	9	have	have	VBP
cord-001835-0s7ok4uw	178	10	proposed	propose	VBN
cord-001835-0s7ok4uw	178	11	that	that	IN
cord-001835-0s7ok4uw	178	12	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	178	13	could	could	MD
cord-001835-0s7ok4uw	178	14	serve	serve	VB
cord-001835-0s7ok4uw	178	15	as	as	IN
cord-001835-0s7ok4uw	178	16	a	a	DT
cord-001835-0s7ok4uw	178	17	target	target	NN
cord-001835-0s7ok4uw	178	18	to	to	TO
cord-001835-0s7ok4uw	178	19	control	control	VB
cord-001835-0s7ok4uw	178	20	P.	p.	NN
cord-001835-0s7ok4uw	178	21	infestans	infestans	NN
cord-001835-0s7ok4uw	178	22	infection	infection	NN
cord-001835-0s7ok4uw	178	23	.	.	.
cord-001835-0s7ok4uw	179	1	The	the	DT
cord-001835-0s7ok4uw	179	2	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	179	3	from	from	IN
cord-001835-0s7ok4uw	179	4	P.	P.	NNP
cord-001835-0s7ok4uw	179	5	infestans	infestans	NNP
cord-001835-0s7ok4uw	179	6	and	and	CC
cord-001835-0s7ok4uw	179	7	S.	S.	NNP
cord-001835-0s7ok4uw	179	8	tuberosum	tuberosum	NN
cord-001835-0s7ok4uw	179	9	differ	differ	VBP
cord-001835-0s7ok4uw	179	10	in	in	IN
cord-001835-0s7ok4uw	179	11	their	-PRON-	PRP$
cord-001835-0s7ok4uw	179	12	fusion	fusion	NN
cord-001835-0s7ok4uw	179	13	order	order	NN
cord-001835-0s7ok4uw	179	14	of	of	IN
cord-001835-0s7ok4uw	179	15	OPRT	OPRT	NNP
cord-001835-0s7ok4uw	179	16	and	and	CC
cord-001835-0s7ok4uw	179	17	ODC	ODC	NNP
cord-001835-0s7ok4uw	179	18	.	.	.
cord-001835-0s7ok4uw	180	1	The	the	DT
cord-001835-0s7ok4uw	180	2	study	study	NN
cord-001835-0s7ok4uw	180	3	of	of	IN
cord-001835-0s7ok4uw	180	4	these	these	DT
cord-001835-0s7ok4uw	180	5	two	two	CD
cord-001835-0s7ok4uw	180	6	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	180	7	could	could	MD
cord-001835-0s7ok4uw	180	8	facilitate	facilitate	VB
cord-001835-0s7ok4uw	180	9	the	the	DT
cord-001835-0s7ok4uw	180	10	design	design	NN
cord-001835-0s7ok4uw	180	11	of	of	IN
cord-001835-0s7ok4uw	180	12	species	species	NN
cord-001835-0s7ok4uw	180	13	-	-	HYPH
cord-001835-0s7ok4uw	180	14	specific	specific	JJ
cord-001835-0s7ok4uw	180	15	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	180	16	,	,	,
cord-001835-0s7ok4uw	180	17	and	and	CC
cord-001835-0s7ok4uw	180	18	might	may	MD
cord-001835-0s7ok4uw	180	19	shed	shed	VB
cord-001835-0s7ok4uw	180	20	light	light	NN
cord-001835-0s7ok4uw	180	21	on	on	IN
cord-001835-0s7ok4uw	180	22	the	the	DT
cord-001835-0s7ok4uw	180	23	effect	effect	NN
cord-001835-0s7ok4uw	180	24	of	of	IN
cord-001835-0s7ok4uw	180	25	fusing	fuse	VBG
cord-001835-0s7ok4uw	180	26	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	180	27	domains	domain	NNS
cord-001835-0s7ok4uw	180	28	in	in	IN
cord-001835-0s7ok4uw	180	29	one	one	CD
cord-001835-0s7ok4uw	180	30	order	order	NN
cord-001835-0s7ok4uw	180	31	or	or	CC
cord-001835-0s7ok4uw	180	32	the	the	DT
cord-001835-0s7ok4uw	180	33	other	other	JJ
cord-001835-0s7ok4uw	180	34	.	.	.
cord-001835-0s7ok4uw	181	1	To	to	IN
cord-001835-0s7ok4uw	181	2	this	this	DT
cord-001835-0s7ok4uw	181	3	end	end	NN
cord-001835-0s7ok4uw	181	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	181	5	carried	carry	VBD
cord-001835-0s7ok4uw	181	6	out	out	RP
cord-001835-0s7ok4uw	181	7	bioinformatic	bioinformatic	JJ
cord-001835-0s7ok4uw	181	8	and	and	CC
cord-001835-0s7ok4uw	181	9	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	181	10	characterization	characterization	NN
cord-001835-0s7ok4uw	181	11	of	of	IN
cord-001835-0s7ok4uw	181	12	the	the	DT
cord-001835-0s7ok4uw	181	13	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	181	14	.	.	.
cord-001835-0s7ok4uw	182	1	Sequence	sequence	NN
cord-001835-0s7ok4uw	182	2	analyses	analysis	NNS
cord-001835-0s7ok4uw	182	3	showed	show	VBD
cord-001835-0s7ok4uw	182	4	20	20	CD
cord-001835-0s7ok4uw	182	5	residue	residue	NN
cord-001835-0s7ok4uw	182	6	differences	difference	NNS
cord-001835-0s7ok4uw	182	7	among	among	IN
cord-001835-0s7ok4uw	182	8	the	the	DT
cord-001835-0s7ok4uw	182	9	P.	P.	NNP
cord-001835-0s7ok4uw	182	10	infestans	infestans	NN
cord-001835-0s7ok4uw	182	11	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	182	12	sequences	sequence	NNS
cord-001835-0s7ok4uw	182	13	from	from	IN
cord-001835-0s7ok4uw	182	14	three	three	CD
cord-001835-0s7ok4uw	182	15	strains	strain	NNS
cord-001835-0s7ok4uw	182	16	:	:	:
cord-001835-0s7ok4uw	182	17	4084	4084	CD
cord-001835-0s7ok4uw	182	18	,	,	,
cord-001835-0s7ok4uw	182	19	1306	1306	CD
cord-001835-0s7ok4uw	182	20	and	and	CC
cord-001835-0s7ok4uw	182	21	T30	T30	NNP
cord-001835-0s7ok4uw	182	22	-	-	HYPH
cord-001835-0s7ok4uw	182	23	4	4	CD
cord-001835-0s7ok4uw	182	24	.	.	.
cord-001835-0s7ok4uw	183	1	Strain	Strain	NNP
cord-001835-0s7ok4uw	183	2	T30	T30	NNP
cord-001835-0s7ok4uw	183	3	-	-	HYPH
cord-001835-0s7ok4uw	183	4	4	4	NNP
cord-001835-0s7ok4uw	183	5	was	be	VBD
cord-001835-0s7ok4uw	183	6	found	find	VBN
cord-001835-0s7ok4uw	183	7	to	to	TO
cord-001835-0s7ok4uw	183	8	have	have	VB
cord-001835-0s7ok4uw	183	9	a	a	DT
cord-001835-0s7ok4uw	183	10	duplicated	duplicate	VBN
cord-001835-0s7ok4uw	183	11	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	183	12	,	,	,
cord-001835-0s7ok4uw	183	13	but	but	CC
cord-001835-0s7ok4uw	183	14	neither	neither	DT
cord-001835-0s7ok4uw	183	15	sequence	sequence	NN
cord-001835-0s7ok4uw	183	16	corresponded	correspond	VBD
cord-001835-0s7ok4uw	183	17	to	to	IN
cord-001835-0s7ok4uw	183	18	the	the	DT
cord-001835-0s7ok4uw	183	19	ones	one	NNS
cord-001835-0s7ok4uw	183	20	predicted	predict	VBN
cord-001835-0s7ok4uw	183	21	previously	previously	RB
cord-001835-0s7ok4uw	183	22	from	from	IN
cord-001835-0s7ok4uw	183	23	the	the	DT
cord-001835-0s7ok4uw	183	24	genome	genome	NN
cord-001835-0s7ok4uw	183	25	.	.	.
cord-001835-0s7ok4uw	184	1	A	a	DT
cord-001835-0s7ok4uw	184	2	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	184	3	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	184	4	from	from	IN
cord-001835-0s7ok4uw	184	5	4084	4084	CD
cord-001835-0s7ok4uw	184	6	strain	strain	NN
cord-001835-0s7ok4uw	184	7	was	be	VBD
cord-001835-0s7ok4uw	184	8	expressed	express	VBN
cord-001835-0s7ok4uw	184	9	in	in	IN
cord-001835-0s7ok4uw	184	10	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	184	11	and	and	CC
cord-001835-0s7ok4uw	184	12	purified	purify	VBN
cord-001835-0s7ok4uw	184	13	but	but	CC
cord-001835-0s7ok4uw	184	14	it	-PRON-	PRP
cord-001835-0s7ok4uw	184	15	showed	show	VBD
cord-001835-0s7ok4uw	184	16	low	low	JJ
cord-001835-0s7ok4uw	184	17	solubility	solubility	NN
cord-001835-0s7ok4uw	184	18	and	and	CC
cord-001835-0s7ok4uw	184	19	was	be	VBD
cord-001835-0s7ok4uw	184	20	inactive	inactive	JJ
cord-001835-0s7ok4uw	184	21	in	in	IN
cord-001835-0s7ok4uw	184	22	vitro	vitro	FW
cord-001835-0s7ok4uw	184	23	.	.	.
cord-001835-0s7ok4uw	185	1	The	the	DT
cord-001835-0s7ok4uw	185	2	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	185	3	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	185	4	from	from	IN
cord-001835-0s7ok4uw	185	5	the	the	DT
cord-001835-0s7ok4uw	185	6	1306	1306	CD
cord-001835-0s7ok4uw	185	7	strain	strain	NN
cord-001835-0s7ok4uw	185	8	complemented	complement	VBD
cord-001835-0s7ok4uw	185	9	both	both	CC
cord-001835-0s7ok4uw	185	10	OPRTase	oprtase	NN
cord-001835-0s7ok4uw	185	11	and	and	CC
cord-001835-0s7ok4uw	185	12	ODCase	ODCase	NNP
cord-001835-0s7ok4uw	185	13	deficient	deficient	JJ
cord-001835-0s7ok4uw	185	14	E.	E.	NNP
cord-001835-0s7ok4uw	185	15	coli	coli	NNS
cord-001835-0s7ok4uw	185	16	strains	strain	NNS
cord-001835-0s7ok4uw	185	17	.	.	.
cord-001835-0s7ok4uw	186	1	A	a	DT
cord-001835-0s7ok4uw	186	2	soluble	soluble	JJ
cord-001835-0s7ok4uw	186	3	,	,	,
cord-001835-0s7ok4uw	186	4	active	active	JJ
cord-001835-0s7ok4uw	186	5	,	,	,
cord-001835-0s7ok4uw	186	6	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	186	7	protein	protein	NN
cord-001835-0s7ok4uw	186	8	was	be	VBD
cord-001835-0s7ok4uw	186	9	expressed	express	VBN
cord-001835-0s7ok4uw	186	10	and	and	CC
cord-001835-0s7ok4uw	186	11	purified	purify	VBN
cord-001835-0s7ok4uw	186	12	in	in	IN
cord-001835-0s7ok4uw	186	13	the	the	DT
cord-001835-0s7ok4uw	186	14	presence	presence	NN
cord-001835-0s7ok4uw	186	15	of	of	IN
cord-001835-0s7ok4uw	186	16	high	high	JJ
cord-001835-0s7ok4uw	186	17	salt	salt	NN
cord-001835-0s7ok4uw	186	18	and	and	CC
cord-001835-0s7ok4uw	186	19	the	the	DT
cord-001835-0s7ok4uw	186	20	product	product	NN
cord-001835-0s7ok4uw	186	21	UMP	UMP	NNP
cord-001835-0s7ok4uw	186	22	(	(	-LRB-
cord-001835-0s7ok4uw	186	23	specific	specific	JJ
cord-001835-0s7ok4uw	186	24	activity	activity	NN
cord-001835-0s7ok4uw	187	1	0.2	0.2	CD
cord-001835-0s7ok4uw	187	2	lmol	lmol	NNP
cord-001835-0s7ok4uw	187	3	min-1	min-1	NNP
cord-001835-0s7ok4uw	187	4	mg-1	mg-1	NNP
cord-001835-0s7ok4uw	187	5	)	)	-RRB-
cord-001835-0s7ok4uw	187	6	.	.	.
cord-001835-0s7ok4uw	188	1	The	the	DT
cord-001835-0s7ok4uw	188	2	sequence	sequence	NN
cord-001835-0s7ok4uw	188	3	SKQ	SKQ	NNP
cord-001835-0s7ok4uw	188	4	was	be	VBD
cord-001835-0s7ok4uw	188	5	found	find	VBN
cord-001835-0s7ok4uw	188	6	at	at	IN
cord-001835-0s7ok4uw	188	7	the	the	DT
cord-001835-0s7ok4uw	188	8	C	C	NNP
cord-001835-0s7ok4uw	188	9	-	-	HYPH
cord-001835-0s7ok4uw	188	10	terminus	terminus	NN
cord-001835-0s7ok4uw	188	11	of	of	IN
cord-001835-0s7ok4uw	188	12	the	the	DT
cord-001835-0s7ok4uw	188	13	P.	P.	NNP
cord-001835-0s7ok4uw	188	14	infestans	infestans	NNP
cord-001835-0s7ok4uw	188	15	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	188	16	sequences	sequence	NNS
cord-001835-0s7ok4uw	188	17	and	and	CC
cord-001835-0s7ok4uw	188	18	resembles	resemble	VBZ
cord-001835-0s7ok4uw	188	19	a	a	DT
cord-001835-0s7ok4uw	188	20	peroxisome	peroxisome	NN
cord-001835-0s7ok4uw	188	21	signal	signal	NN
cord-001835-0s7ok4uw	188	22	peptide	peptide	NN
cord-001835-0s7ok4uw	188	23	(	(	-LRB-
cord-001835-0s7ok4uw	188	24	SKL	SKL	NNP
cord-001835-0s7ok4uw	188	25	)	)	-RRB-
cord-001835-0s7ok4uw	188	26	.	.	.
cord-001835-0s7ok4uw	189	1	The	the	DT
cord-001835-0s7ok4uw	189	2	predicted	predict	VBN
cord-001835-0s7ok4uw	189	3	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	189	4	of	of	IN
cord-001835-0s7ok4uw	189	5	this	this	DT
cord-001835-0s7ok4uw	189	6	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	189	7	and	and	CC
cord-001835-0s7ok4uw	189	8	its	-PRON-	PRP$
cord-001835-0s7ok4uw	189	9	architecture	architecture	NN
cord-001835-0s7ok4uw	189	10	(	(	-LRB-
cord-001835-0s7ok4uw	189	11	OPRT	OPRT	NNP
cord-001835-0s7ok4uw	189	12	at	at	IN
cord-001835-0s7ok4uw	189	13	the	the	DT
cord-001835-0s7ok4uw	189	14	C	C	NNP
cord-001835-0s7ok4uw	189	15	-	-	HYPH
cord-001835-0s7ok4uw	189	16	terminus	terminus	NN
cord-001835-0s7ok4uw	189	17	and	and	CC
cord-001835-0s7ok4uw	189	18	ODC	ODC	NNP
cord-001835-0s7ok4uw	189	19	at	at	IN
cord-001835-0s7ok4uw	189	20	the	the	DT
cord-001835-0s7ok4uw	189	21	N	n	CD
cord-001835-0s7ok4uw	189	22	-	-	HYPH
cord-001835-0s7ok4uw	189	23	terminus	terminus	NN
cord-001835-0s7ok4uw	189	24	)	)	-RRB-
cord-001835-0s7ok4uw	189	25	resembles	resemble	VBZ
cord-001835-0s7ok4uw	189	26	that	that	DT
cord-001835-0s7ok4uw	189	27	of	of	IN
cord-001835-0s7ok4uw	189	28	the	the	DT
cord-001835-0s7ok4uw	189	29	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	189	30	from	from	IN
cord-001835-0s7ok4uw	189	31	Leishmania	Leishmania	NNP
cord-001835-0s7ok4uw	189	32	donovani	donovani	NNP
cord-001835-0s7ok4uw	189	33	,	,	,
cord-001835-0s7ok4uw	189	34	which	which	WDT
cord-001835-0s7ok4uw	189	35	has	have	VBZ
cord-001835-0s7ok4uw	189	36	been	be	VBN
cord-001835-0s7ok4uw	189	37	localized	localize	VBN
cord-001835-0s7ok4uw	189	38	to	to	IN
cord-001835-0s7ok4uw	189	39	the	the	DT
cord-001835-0s7ok4uw	189	40	peroxisome	peroxisome	NN
cord-001835-0s7ok4uw	189	41	.	.	.
cord-001835-0s7ok4uw	190	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	190	2	suggest	suggest	VBP
cord-001835-0s7ok4uw	190	3	that	that	IN
cord-001835-0s7ok4uw	190	4	P.	P.	NNP
cord-001835-0s7ok4uw	190	5	infestans	infestans	NNP
cord-001835-0s7ok4uw	190	6	UMPS	UMPS	NNP
cord-001835-0s7ok4uw	190	7	could	could	MD
cord-001835-0s7ok4uw	190	8	also	also	RB
cord-001835-0s7ok4uw	190	9	be	be	VB
cord-001835-0s7ok4uw	190	10	located	locate	VBN
cord-001835-0s7ok4uw	190	11	in	in	IN
cord-001835-0s7ok4uw	190	12	this	this	DT
cord-001835-0s7ok4uw	190	13	organelle	organelle	NN
cord-001835-0s7ok4uw	190	14	.	.	.
cord-001835-0s7ok4uw	191	1	In	in	IN
cord-001835-0s7ok4uw	191	2	contrast	contrast	NN
cord-001835-0s7ok4uw	191	3	to	to	IN
cord-001835-0s7ok4uw	191	4	the	the	DT
cord-001835-0s7ok4uw	191	5	oomycete	oomycete	NN
cord-001835-0s7ok4uw	191	6	enzyme	enzyme	NN
cord-001835-0s7ok4uw	191	7	,	,	,
cord-001835-0s7ok4uw	191	8	S.	S.	NNP
cord-001835-0s7ok4uw	191	9	tuberosum	tuberosum	NN
cord-001835-0s7ok4uw	191	10	UMPase	UMPase	NNP
cord-001835-0s7ok4uw	191	11	is	be	VBZ
cord-001835-0s7ok4uw	191	12	highly	highly	RB
cord-001835-0s7ok4uw	191	13	soluble	soluble	JJ
cord-001835-0s7ok4uw	191	14	,	,	,
cord-001835-0s7ok4uw	191	15	and	and	CC
cord-001835-0s7ok4uw	191	16	has	have	VBZ
cord-001835-0s7ok4uw	191	17	a	a	DT
cord-001835-0s7ok4uw	191	18	higher	high	JJR
cord-001835-0s7ok4uw	191	19	specific	specific	JJ
cord-001835-0s7ok4uw	191	20	activity	activity	NN
cord-001835-0s7ok4uw	191	21	(	(	-LRB-
cord-001835-0s7ok4uw	191	22	Vmax5	Vmax5	NNP
cord-001835-0s7ok4uw	191	23	8.8	8.8	CD
cord-001835-0s7ok4uw	191	24	lmol	lmol	NN
cord-001835-0s7ok4uw	191	25	min-1	min-1	NNP
cord-001835-0s7ok4uw	191	26	mg-1	mg-1	NNP
cord-001835-0s7ok4uw	191	27	)	)	-RRB-
cord-001835-0s7ok4uw	191	28	.	.	.
cord-001835-0s7ok4uw	192	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	192	2	measured	measure	VBD
cord-001835-0s7ok4uw	192	3	the	the	DT
cord-001835-0s7ok4uw	192	4	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	192	5	parameters	parameter	NNS
cord-001835-0s7ok4uw	192	6	KM(orotate)5	KM(orotate)5	NNS
cord-001835-0s7ok4uw	192	7	16.2	16.2	CD
cord-001835-0s7ok4uw	192	8	lM	lM	NNP
cord-001835-0s7ok4uw	192	9	,	,	,
cord-001835-0s7ok4uw	192	10	KM(PRPP)5	KM(PRPP)5	NNP
cord-001835-0s7ok4uw	192	11	25.5	25.5	CD
cord-001835-0s7ok4uw	192	12	lM	lM	NNP
cord-001835-0s7ok4uw	192	13	,	,	,
cord-001835-0s7ok4uw	192	14	and	and	CC
cord-001835-0s7ok4uw	192	15	found	find	VBD
cord-001835-0s7ok4uw	192	16	that	that	IN
cord-001835-0s7ok4uw	192	17	it	-PRON-	PRP
cord-001835-0s7ok4uw	192	18	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	192	19	product	product	NN
cord-001835-0s7ok4uw	192	20	inhibition	inhibition	NN
cord-001835-0s7ok4uw	192	21	by	by	IN
cord-001835-0s7ok4uw	192	22	pyrophosphate	pyrophosphate	NN
cord-001835-0s7ok4uw	192	23	.	.	.
cord-001835-0s7ok4uw	193	1	In	in	IN
cord-001835-0s7ok4uw	193	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	193	3	,	,	,
cord-001835-0s7ok4uw	193	4	the	the	DT
cord-001835-0s7ok4uw	193	5	different	different	JJ
cord-001835-0s7ok4uw	193	6	architectures	architecture	NNS
cord-001835-0s7ok4uw	193	7	of	of	IN
cord-001835-0s7ok4uw	193	8	the	the	DT
cord-001835-0s7ok4uw	193	9	two	two	CD
cord-001835-0s7ok4uw	193	10	UMPS	ump	NNS
cord-001835-0s7ok4uw	193	11	might	may	MD
cord-001835-0s7ok4uw	193	12	be	be	VB
cord-001835-0s7ok4uw	193	13	related	relate	VBN
cord-001835-0s7ok4uw	193	14	to	to	IN
cord-001835-0s7ok4uw	193	15	distinct	distinct	JJ
cord-001835-0s7ok4uw	193	16	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	193	17	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	193	18	,	,	,
cord-001835-0s7ok4uw	193	19	further	further	RB
cord-001835-0s7ok4uw	193	20	supporting	support	VBG
cord-001835-0s7ok4uw	193	21	this	this	DT
cord-001835-0s7ok4uw	193	22	protein	protein	NN
cord-001835-0s7ok4uw	193	23	as	as	IN
cord-001835-0s7ok4uw	193	24	a	a	DT
cord-001835-0s7ok4uw	193	25	good	good	JJ
cord-001835-0s7ok4uw	193	26	candidate	candidate	NN
cord-001835-0s7ok4uw	193	27	for	for	IN
cord-001835-0s7ok4uw	193	28	P.	P.	NNP
cord-001835-0s7ok4uw	193	29	infestans	infestans	NNP
cord-001835-0s7ok4uw	193	30	control	control	NN
cord-001835-0s7ok4uw	193	31	.	.	.
cord-001835-0s7ok4uw	194	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	194	2	present	present	VBP
cord-001835-0s7ok4uw	194	3	computer	computer	NN
cord-001835-0s7ok4uw	194	4	simulation	simulation	NN
cord-001835-0s7ok4uw	194	5	studies	study	NNS
cord-001835-0s7ok4uw	194	6	of	of	IN
cord-001835-0s7ok4uw	194	7	three	three	CD
cord-001835-0s7ok4uw	194	8	different	different	JJ
cord-001835-0s7ok4uw	194	9	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	194	10	peptides	peptide	NNS
cord-001835-0s7ok4uw	194	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	194	12	have	have	VBP
cord-001835-0s7ok4uw	194	13	been	be	VBN
cord-001835-0s7ok4uw	194	14	studying	study	VBG
cord-001835-0s7ok4uw	194	15	by	by	IN
cord-001835-0s7ok4uw	194	16	MD	MD	NNP
cord-001835-0s7ok4uw	194	17	computer	computer	NN
cord-001835-0s7ok4uw	194	18	simulation	simulation	NN
cord-001835-0s7ok4uw	194	19	in	in	IN
cord-001835-0s7ok4uw	194	20	collaboration	collaboration	NN
cord-001835-0s7ok4uw	194	21	with	with	IN
cord-001835-0s7ok4uw	194	22	experimentalists	experimentalist	NNS
cord-001835-0s7ok4uw	194	23	.	.	.
cord-001835-0s7ok4uw	195	1	The	the	DT
cord-001835-0s7ok4uw	195	2	first	first	JJ
cord-001835-0s7ok4uw	195	3	is	be	VBZ
cord-001835-0s7ok4uw	195	4	Daptomycin	Daptomycin	NNP
cord-001835-0s7ok4uw	195	5	,	,	,
cord-001835-0s7ok4uw	195	6	a	a	DT
cord-001835-0s7ok4uw	195	7	potent	potent	JJ
cord-001835-0s7ok4uw	195	8	lipopeptide	lipopeptide	NN
cord-001835-0s7ok4uw	195	9	currently	currently	RB
cord-001835-0s7ok4uw	195	10	licensed	license	VBN
cord-001835-0s7ok4uw	195	11	to	to	TO
cord-001835-0s7ok4uw	195	12	treat	treat	VB
cord-001835-0s7ok4uw	195	13	infections	infection	NNS
cord-001835-0s7ok4uw	195	14	caused	cause	VBN
cord-001835-0s7ok4uw	195	15	by	by	IN
cord-001835-0s7ok4uw	195	16	multi	multi	JJ
cord-001835-0s7ok4uw	195	17	-	-	JJ
cord-001835-0s7ok4uw	195	18	drug	drug	JJ
cord-001835-0s7ok4uw	195	19	-	-	HYPH
cord-001835-0s7ok4uw	195	20	resistent	resistent	NN
cord-001835-0s7ok4uw	195	21	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	195	22	.	.	.
cord-001835-0s7ok4uw	196	1	The	the	DT
cord-001835-0s7ok4uw	196	2	mechanism	mechanism	NN
cord-001835-0s7ok4uw	196	3	of	of	IN
cord-001835-0s7ok4uw	196	4	action	action	NN
cord-001835-0s7ok4uw	196	5	of	of	IN
cord-001835-0s7ok4uw	196	6	Daptomycin	Daptomycin	NNP
cord-001835-0s7ok4uw	196	7	is	be	VBZ
cord-001835-0s7ok4uw	196	8	currently	currently	RB
cord-001835-0s7ok4uw	196	9	not	not	RB
cord-001835-0s7ok4uw	196	10	completely	completely	RB
cord-001835-0s7ok4uw	196	11	understood	understand	VBN
cord-001835-0s7ok4uw	196	12	.	.	.
cord-001835-0s7ok4uw	197	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	197	2	have	have	VBP
cord-001835-0s7ok4uw	197	3	solved	solve	VBN
cord-001835-0s7ok4uw	197	4	the	the	DT
cord-001835-0s7ok4uw	197	5	NMR	NMR	NNP
cord-001835-0s7ok4uw	197	6	structure	structure	NN
cord-001835-0s7ok4uw	197	7	of	of	IN
cord-001835-0s7ok4uw	197	8	this	this	DT
cord-001835-0s7ok4uw	197	9	molecule	molecule	NN
cord-001835-0s7ok4uw	197	10	,	,	,
cord-001835-0s7ok4uw	197	11	and	and	CC
cord-001835-0s7ok4uw	197	12	attempted	attempt	VBD
cord-001835-0s7ok4uw	197	13	to	to	TO
cord-001835-0s7ok4uw	197	14	determine	determine	VB
cord-001835-0s7ok4uw	197	15	the	the	DT
cord-001835-0s7ok4uw	197	16	size	size	NN
cord-001835-0s7ok4uw	197	17	of	of	IN
cord-001835-0s7ok4uw	197	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	197	19	oligomer	oligomer	NNP
cord-001835-0s7ok4uw	197	20	by	by	IN
cord-001835-0s7ok4uw	197	21	small	small	JJ
cord-001835-0s7ok4uw	197	22	angle	angle	NN
cord-001835-0s7ok4uw	197	23	neutron	neutron	NN
cord-001835-0s7ok4uw	197	24	scattering	scattering	NN
cord-001835-0s7ok4uw	197	25	(	(	-LRB-
cord-001835-0s7ok4uw	197	26	SANS	sans	NN
cord-001835-0s7ok4uw	197	27	)	)	-RRB-
cord-001835-0s7ok4uw	197	28	supported	support	VBN
cord-001835-0s7ok4uw	197	29	by	by	IN
cord-001835-0s7ok4uw	197	30	computer	computer	NN
cord-001835-0s7ok4uw	197	31	simulation	simulation	NN
cord-001835-0s7ok4uw	197	32	.	.	.
cord-001835-0s7ok4uw	198	1	Feglymycin	Feglymycin	NNP
cord-001835-0s7ok4uw	198	2	is	be	VBZ
cord-001835-0s7ok4uw	198	3	a	a	DT
cord-001835-0s7ok4uw	198	4	13-amino	13-amino	CD
cord-001835-0s7ok4uw	198	5	-	-	HYPH
cord-001835-0s7ok4uw	198	6	acid	acid	NN
cord-001835-0s7ok4uw	198	7	peptide	peptide	NN
cord-001835-0s7ok4uw	198	8	with	with	IN
cord-001835-0s7ok4uw	198	9	a	a	DT
cord-001835-0s7ok4uw	198	10	high	high	JJ
cord-001835-0s7ok4uw	198	11	percentage	percentage	NN
cord-001835-0s7ok4uw	198	12	of	of	IN
cord-001835-0s7ok4uw	198	13	unusual	unusual	JJ
cord-001835-0s7ok4uw	198	14	amino	amino	NN
cord-001835-0s7ok4uw	198	15	acids	acid	NNS
cord-001835-0s7ok4uw	198	16	such	such	JJ
cord-001835-0s7ok4uw	198	17	as	as	IN
cord-001835-0s7ok4uw	198	18	4-hydroxyphenylglycine	4-hydroxyphenylglycine	CD
cord-001835-0s7ok4uw	198	19	and	and	CC
cord-001835-0s7ok4uw	198	20	3,5-dihydroxyphenylglycine	3,5-dihydroxyphenylglycine	CD
cord-001835-0s7ok4uw	198	21	.	.	.
cord-001835-0s7ok4uw	199	1	Feglymicin	Feglymicin	NNP
cord-001835-0s7ok4uw	199	2	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	199	3	MurA	MurA	NNP
cord-001835-0s7ok4uw	199	4	and	and	CC
cord-001835-0s7ok4uw	199	5	MurC	MurC	NNP
cord-001835-0s7ok4uw	199	6	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	199	7	which	which	WDT
cord-001835-0s7ok4uw	199	8	are	be	VBP
cord-001835-0s7ok4uw	199	9	involved	involve	VBN
cord-001835-0s7ok4uw	199	10	in	in	IN
cord-001835-0s7ok4uw	199	11	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	199	12	peptidoglycan	peptidoglycan	NN
cord-001835-0s7ok4uw	199	13	synthesis	synthesis	NN
cord-001835-0s7ok4uw	199	14	,	,	,
cord-001835-0s7ok4uw	199	15	while	while	IN
cord-001835-0s7ok4uw	199	16	also	also	RB
cord-001835-0s7ok4uw	199	17	displaying	display	VBG
cord-001835-0s7ok4uw	199	18	anti	anti	JJ
cord-001835-0s7ok4uw	199	19	-	-	JJ
cord-001835-0s7ok4uw	199	20	HIV	hiv	JJ
cord-001835-0s7ok4uw	199	21	activity	activity	NN
cord-001835-0s7ok4uw	199	22	by	by	IN
cord-001835-0s7ok4uw	199	23	interaction	interaction	NN
cord-001835-0s7ok4uw	199	24	with	with	IN
cord-001835-0s7ok4uw	199	25	the	the	DT
cord-001835-0s7ok4uw	199	26	viral	viral	JJ
cord-001835-0s7ok4uw	199	27	envelope	envelope	NN
cord-001835-0s7ok4uw	199	28	protein	protein	NN
cord-001835-0s7ok4uw	199	29	gp120	gp120	NNP
cord-001835-0s7ok4uw	199	30	.	.	.
cord-001835-0s7ok4uw	200	1	A	a	DT
cord-001835-0s7ok4uw	200	2	previous	previous	JJ
cord-001835-0s7ok4uw	200	3	X	x	NN
cord-001835-0s7ok4uw	200	4	-	-	NN
cord-001835-0s7ok4uw	200	5	ray	ray	JJ
cord-001835-0s7ok4uw	200	6	structure	structure	NN
cord-001835-0s7ok4uw	200	7	shows	show	VBZ
cord-001835-0s7ok4uw	200	8	the	the	DT
cord-001835-0s7ok4uw	200	9	molecule	molecule	NN
cord-001835-0s7ok4uw	200	10	forming	form	VBG
cord-001835-0s7ok4uw	200	11	a	a	DT
cord-001835-0s7ok4uw	200	12	dimer	dimer	NN
cord-001835-0s7ok4uw	200	13	.	.	.
cord-001835-0s7ok4uw	201	1	Here	here	RB
cord-001835-0s7ok4uw	201	2	,	,	,
cord-001835-0s7ok4uw	201	3	the	the	DT
cord-001835-0s7ok4uw	201	4	molecule	molecule	NN
cord-001835-0s7ok4uw	201	5	was	be	VBD
cord-001835-0s7ok4uw	201	6	studied	study	VBN
cord-001835-0s7ok4uw	201	7	by	by	IN
cord-001835-0s7ok4uw	201	8	NMR	NMR	NNP
cord-001835-0s7ok4uw	201	9	in	in	IN
cord-001835-0s7ok4uw	201	10	water	water	NN
cord-001835-0s7ok4uw	201	11	and	and	CC
cord-001835-0s7ok4uw	201	12	DMSO	DMSO	NNP
cord-001835-0s7ok4uw	201	13	.	.	.
cord-001835-0s7ok4uw	202	1	In	in	IN
cord-001835-0s7ok4uw	202	2	water	water	NN
cord-001835-0s7ok4uw	202	3	,	,	,
cord-001835-0s7ok4uw	202	4	the	the	DT
cord-001835-0s7ok4uw	202	5	molecule	molecule	NN
cord-001835-0s7ok4uw	202	6	is	be	VBZ
cord-001835-0s7ok4uw	202	7	clearly	clearly	RB
cord-001835-0s7ok4uw	202	8	at	at	IN
cord-001835-0s7ok4uw	202	9	least	least	JJS
cord-001835-0s7ok4uw	202	10	a	a	DT
cord-001835-0s7ok4uw	202	11	dimer	dimer	NN
cord-001835-0s7ok4uw	202	12	,	,	,
cord-001835-0s7ok4uw	202	13	while	while	IN
cord-001835-0s7ok4uw	202	14	in	in	IN
cord-001835-0s7ok4uw	202	15	DMSO	DMSO	NNP
cord-001835-0s7ok4uw	202	16	it	-PRON-	PRP
cord-001835-0s7ok4uw	202	17	is	be	VBZ
cord-001835-0s7ok4uw	202	18	a	a	DT
cord-001835-0s7ok4uw	202	19	monomer	monomer	NN
cord-001835-0s7ok4uw	202	20	.	.	.
cord-001835-0s7ok4uw	203	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	203	2	have	have	VBP
cord-001835-0s7ok4uw	203	3	performed	perform	VBN
cord-001835-0s7ok4uw	203	4	NOE	NOE	NNP
cord-001835-0s7ok4uw	203	5	refinement	refinement	NN
cord-001835-0s7ok4uw	203	6	simulations	simulation	NNS
cord-001835-0s7ok4uw	203	7	in	in	IN
cord-001835-0s7ok4uw	203	8	order	order	NN
cord-001835-0s7ok4uw	203	9	to	to	TO
cord-001835-0s7ok4uw	203	10	elucidate	elucidate	VB
cord-001835-0s7ok4uw	203	11	a	a	DT
cord-001835-0s7ok4uw	203	12	structure	structure	NN
cord-001835-0s7ok4uw	203	13	,	,	,
cord-001835-0s7ok4uw	203	14	however	however	RB
cord-001835-0s7ok4uw	203	15	,	,	,
cord-001835-0s7ok4uw	203	16	due	due	IN
cord-001835-0s7ok4uw	203	17	to	to	IN
cord-001835-0s7ok4uw	203	18	a	a	DT
cord-001835-0s7ok4uw	203	19	lack	lack	NN
cord-001835-0s7ok4uw	203	20	of	of	IN
cord-001835-0s7ok4uw	203	21	long	long	JJ
cord-001835-0s7ok4uw	203	22	-	-	HYPH
cord-001835-0s7ok4uw	203	23	range	range	NN
cord-001835-0s7ok4uw	203	24	NOE	NOE	NNP
cord-001835-0s7ok4uw	203	25	contacts	contact	NNS
cord-001835-0s7ok4uw	203	26	,	,	,
cord-001835-0s7ok4uw	203	27	a	a	DT
cord-001835-0s7ok4uw	203	28	unique	unique	JJ
cord-001835-0s7ok4uw	203	29	structure	structure	NN
cord-001835-0s7ok4uw	203	30	can	can	MD
cord-001835-0s7ok4uw	203	31	not	not	RB
cord-001835-0s7ok4uw	203	32	be	be	VB
cord-001835-0s7ok4uw	203	33	determined	determine	VBN
cord-001835-0s7ok4uw	203	34	.	.	.
cord-001835-0s7ok4uw	204	1	Labyrinthopeptin	Labyrinthopeptin	NNP
cord-001835-0s7ok4uw	204	2	A2	A2	NNP
cord-001835-0s7ok4uw	204	3	is	be	VBZ
cord-001835-0s7ok4uw	204	4	a	a	DT
cord-001835-0s7ok4uw	204	5	lantibiotic	lantibiotic	NN
cord-001835-0s7ok4uw	204	6	that	that	WDT
cord-001835-0s7ok4uw	204	7	contains	contain	VBZ
cord-001835-0s7ok4uw	204	8	labionin	labionin	NN
cord-001835-0s7ok4uw	204	9	,	,	,
cord-001835-0s7ok4uw	204	10	a	a	DT
cord-001835-0s7ok4uw	204	11	unique	unique	JJ
cord-001835-0s7ok4uw	204	12	carbacyclic	carbacyclic	NN
cord-001835-0s7ok4uw	204	13	posttranslationally	posttranslationally	RB
cord-001835-0s7ok4uw	204	14	modified	modify	VBN
cord-001835-0s7ok4uw	204	15	amino	amino	NN
cord-001835-0s7ok4uw	204	16	acid	acid	NN
cord-001835-0s7ok4uw	204	17	that	that	WDT
cord-001835-0s7ok4uw	204	18	links	link	VBZ
cord-001835-0s7ok4uw	204	19	the	the	DT
cord-001835-0s7ok4uw	204	20	protein	protein	NN
cord-001835-0s7ok4uw	204	21	backbone	backbone	NN
cord-001835-0s7ok4uw	204	22	in	in	IN
cord-001835-0s7ok4uw	204	23	three	three	CD
cord-001835-0s7ok4uw	204	24	different	different	JJ
cord-001835-0s7ok4uw	204	25	locations	location	NNS
cord-001835-0s7ok4uw	204	26	.	.	.
cord-001835-0s7ok4uw	205	1	Labyrinthopeptin	Labyrinthopeptin	NNP
cord-001835-0s7ok4uw	205	2	A2	A2	NNP
cord-001835-0s7ok4uw	205	3	has	have	VBZ
cord-001835-0s7ok4uw	205	4	shown	show	VBN
cord-001835-0s7ok4uw	205	5	promising	promising	JJ
cord-001835-0s7ok4uw	205	6	activity	activity	NN
cord-001835-0s7ok4uw	205	7	as	as	IN
cord-001835-0s7ok4uw	205	8	a	a	DT
cord-001835-0s7ok4uw	205	9	pain	pain	NN
cord-001835-0s7ok4uw	205	10	killer	killer	NN
cord-001835-0s7ok4uw	205	11	.	.	.
cord-001835-0s7ok4uw	206	1	Starting	start	VBG
cord-001835-0s7ok4uw	206	2	from	from	IN
cord-001835-0s7ok4uw	206	3	the	the	DT
cord-001835-0s7ok4uw	206	4	X	x	NN
cord-001835-0s7ok4uw	206	5	-	-	NN
cord-001835-0s7ok4uw	206	6	ray	ray	JJ
cord-001835-0s7ok4uw	206	7	structure	structure	NN
cord-001835-0s7ok4uw	206	8	,	,	,
cord-001835-0s7ok4uw	206	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	206	10	present	present	VBP
cord-001835-0s7ok4uw	206	11	results	result	NNS
cord-001835-0s7ok4uw	206	12	from	from	IN
cord-001835-0s7ok4uw	206	13	the	the	DT
cord-001835-0s7ok4uw	206	14	first	first	JJ
cord-001835-0s7ok4uw	206	15	MD	MD	NNP
cord-001835-0s7ok4uw	206	16	simulation	simulation	NN
cord-001835-0s7ok4uw	206	17	studies	study	NNS
cord-001835-0s7ok4uw	206	18	of	of	IN
cord-001835-0s7ok4uw	206	19	this	this	DT
cord-001835-0s7ok4uw	206	20	unique	unique	JJ
cord-001835-0s7ok4uw	206	21	peptide	peptide	NN
cord-001835-0s7ok4uw	206	22	.	.	.
cord-001835-0s7ok4uw	207	1	Because	because	IN
cord-001835-0s7ok4uw	207	2	of	of	IN
cord-001835-0s7ok4uw	207	3	the	the	DT
cord-001835-0s7ok4uw	207	4	extensive	extensive	JJ
cord-001835-0s7ok4uw	207	5	cross	cross	NN
cord-001835-0s7ok4uw	207	6	-	-	JJ
cord-001835-0s7ok4uw	207	7	linking	linking	NN
cord-001835-0s7ok4uw	207	8	,	,	,
cord-001835-0s7ok4uw	207	9	this	this	DT
cord-001835-0s7ok4uw	207	10	peptide	peptide	NN
cord-001835-0s7ok4uw	207	11	is	be	VBZ
cord-001835-0s7ok4uw	207	12	observed	observe	VBN
cord-001835-0s7ok4uw	207	13	to	to	TO
cord-001835-0s7ok4uw	207	14	be	be	VB
cord-001835-0s7ok4uw	207	15	highly	highly	RB
cord-001835-0s7ok4uw	207	16	rigid	rigid	JJ
cord-001835-0s7ok4uw	207	17	in	in	IN
cord-001835-0s7ok4uw	207	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	207	19	native	native	JJ
cord-001835-0s7ok4uw	207	20	form	form	NN
cord-001835-0s7ok4uw	207	21	.	.	.
cord-001835-0s7ok4uw	208	1	Simulation	simulation	NN
cord-001835-0s7ok4uw	208	2	results	result	NNS
cord-001835-0s7ok4uw	208	3	of	of	IN
cord-001835-0s7ok4uw	208	4	mutants	mutant	NNS
cord-001835-0s7ok4uw	208	5	are	be	VBP
cord-001835-0s7ok4uw	208	6	also	also	RB
cord-001835-0s7ok4uw	208	7	presented	present	VBN
cord-001835-0s7ok4uw	208	8	.	.	.
cord-001835-0s7ok4uw	208	9	 	 	_SP
cord-001835-0s7ok4uw	209	1	Antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	209	2	with	with	IN
cord-001835-0s7ok4uw	209	3	new	new	JJ
cord-001835-0s7ok4uw	209	4	mechanism	mechanism	NN
cord-001835-0s7ok4uw	209	5	of	of	IN
cord-001835-0s7ok4uw	209	6	action	action	NN
cord-001835-0s7ok4uw	209	7	are	be	VBP
cord-001835-0s7ok4uw	209	8	urgently	urgently	RB
cord-001835-0s7ok4uw	209	9	required	require	VBN
cord-001835-0s7ok4uw	209	10	to	to	TO
cord-001835-0s7ok4uw	209	11	combat	combat	VB
cord-001835-0s7ok4uw	209	12	the	the	DT
cord-001835-0s7ok4uw	209	13	growing	grow	VBG
cord-001835-0s7ok4uw	209	14	health	health	NN
cord-001835-0s7ok4uw	209	15	threat	threat	NN
cord-001835-0s7ok4uw	209	16	posed	pose	VBN
cord-001835-0s7ok4uw	209	17	by	by	IN
cord-001835-0s7ok4uw	209	18	resistant	resistant	JJ
cord-001835-0s7ok4uw	209	19	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	209	20	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	209	21	.	.	.
cord-001835-0s7ok4uw	210	1	Here	here	RB
cord-001835-0s7ok4uw	210	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	210	3	report	report	VBP
cord-001835-0s7ok4uw	210	4	the	the	DT
cord-001835-0s7ok4uw	210	5	discovery	discovery	NN
cord-001835-0s7ok4uw	210	6	of	of	IN
cord-001835-0s7ok4uw	210	7	a	a	DT
cord-001835-0s7ok4uw	210	8	new	new	JJ
cord-001835-0s7ok4uw	210	9	peptidomimetic	peptidomimetic	JJ
cord-001835-0s7ok4uw	210	10	antibiotic	antibiotic	NN
cord-001835-0s7ok4uw	210	11	(	(	-LRB-
cord-001835-0s7ok4uw	210	12	L27	L27	NNP
cord-001835-0s7ok4uw	210	13	-	-	HYPH
cord-001835-0s7ok4uw	210	14	11	11	CD
cord-001835-0s7ok4uw	210	15	)	)	-RRB-
cord-001835-0s7ok4uw	210	16	,	,	,
cord-001835-0s7ok4uw	210	17	which	which	WDT
cord-001835-0s7ok4uw	210	18	is	be	VBZ
cord-001835-0s7ok4uw	210	19	active	active	JJ
cord-001835-0s7ok4uw	210	20	with	with	IN
cord-001835-0s7ok4uw	210	21	a	a	DT
cord-001835-0s7ok4uw	210	22	minimum	minimum	JJ
cord-001835-0s7ok4uw	210	23	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	210	24	concentration	concentration	NN
cord-001835-0s7ok4uw	210	25	(	(	-LRB-
cord-001835-0s7ok4uw	210	26	MIC	MIC	NNP
cord-001835-0s7ok4uw	210	27	)	)	-RRB-
cord-001835-0s7ok4uw	210	28	in	in	IN
cord-001835-0s7ok4uw	210	29	the	the	DT
cord-001835-0s7ok4uw	210	30	low	low	JJ
cord-001835-0s7ok4uw	210	31	nanomolar	nanomolar	JJ
cord-001835-0s7ok4uw	210	32	range	range	NN
cord-001835-0s7ok4uw	210	33	,	,	,
cord-001835-0s7ok4uw	210	34	only	only	RB
cord-001835-0s7ok4uw	210	35	against	against	IN
cord-001835-0s7ok4uw	210	36	Pseudomonas	Pseudomonas	NNP
cord-001835-0s7ok4uw	210	37	sp	sp	NNP
cord-001835-0s7ok4uw	210	38	.	.	NNP
cord-001835-0s7ok4uw	210	39	,	,	,
cord-001835-0s7ok4uw	210	40	and	and	CC
cord-001835-0s7ok4uw	210	41	with	with	IN
cord-001835-0s7ok4uw	210	42	a	a	DT
cord-001835-0s7ok4uw	210	43	non	non	JJ
cord-001835-0s7ok4uw	210	44	-	-	JJ
cord-001835-0s7ok4uw	210	45	membrane	membrane	JJ
cord-001835-0s7ok4uw	210	46	-	-	HYPH
cord-001835-0s7ok4uw	210	47	lytic	lytic	JJ
cord-001835-0s7ok4uw	210	48	mechanism	mechanism	NN
cord-001835-0s7ok4uw	210	49	of	of	IN
cord-001835-0s7ok4uw	210	50	action	action	NN
cord-001835-0s7ok4uw	210	51	.	.	.
cord-001835-0s7ok4uw	211	1	A	a	DT
cord-001835-0s7ok4uw	211	2	drug	drug	NN
cord-001835-0s7ok4uw	211	3	target	target	NN
cord-001835-0s7ok4uw	211	4	identified	identify	VBN
cord-001835-0s7ok4uw	211	5	both	both	CC
cord-001835-0s7ok4uw	211	6	in	in	IN
cord-001835-0s7ok4uw	211	7	a	a	DT
cord-001835-0s7ok4uw	211	8	forward	forward	JJ
cord-001835-0s7ok4uw	211	9	genetic	genetic	JJ
cord-001835-0s7ok4uw	211	10	screen	screen	NN
cord-001835-0s7ok4uw	211	11	for	for	IN
cord-001835-0s7ok4uw	211	12	resistance	resistance	NN
cord-001835-0s7ok4uw	211	13	determinants	determinant	NNS
cord-001835-0s7ok4uw	211	14	and	and	CC
cord-001835-0s7ok4uw	211	15	by	by	IN
cord-001835-0s7ok4uw	211	16	photoaffinity	photoaffinity	NN
cord-001835-0s7ok4uw	211	17	labeling	labeling	NN
cord-001835-0s7ok4uw	211	18	is	be	VBZ
cord-001835-0s7ok4uw	211	19	the	the	DT
cord-001835-0s7ok4uw	211	20	ß	ß	NN
cord-001835-0s7ok4uw	211	21	-	-	HYPH
cord-001835-0s7ok4uw	211	22	barrel	barrel	NN
cord-001835-0s7ok4uw	211	23	protein	protein	NN
cord-001835-0s7ok4uw	211	24	LptD	LptD	NNP
cord-001835-0s7ok4uw	211	25	,	,	,
cord-001835-0s7ok4uw	211	26	which	which	WDT
cord-001835-0s7ok4uw	211	27	plays	play	VBZ
cord-001835-0s7ok4uw	211	28	an	an	DT
cord-001835-0s7ok4uw	211	29	important	important	JJ
cord-001835-0s7ok4uw	211	30	role	role	NN
cord-001835-0s7ok4uw	211	31	in	in	IN
cord-001835-0s7ok4uw	211	32	LPS	LPS	NNP
cord-001835-0s7ok4uw	211	33	transport	transport	NN
cord-001835-0s7ok4uw	211	34	and	and	CC
cord-001835-0s7ok4uw	211	35	the	the	DT
cord-001835-0s7ok4uw	211	36	outer	outer	JJ
cord-001835-0s7ok4uw	211	37	membrane	membrane	NN
cord-001835-0s7ok4uw	211	38	biogenesis	biogenesis	NN
cord-001835-0s7ok4uw	211	39	.	.	.
cord-001835-0s7ok4uw	212	1	The	the	DT
cord-001835-0s7ok4uw	212	2	X	x	NN
cord-001835-0s7ok4uw	212	3	-	-	NN
cord-001835-0s7ok4uw	212	4	ray	ray	JJ
cord-001835-0s7ok4uw	212	5	structure	structure	NN
cord-001835-0s7ok4uw	212	6	of	of	IN
cord-001835-0s7ok4uw	212	7	LptD	LptD	NNP
cord-001835-0s7ok4uw	212	8	in	in	IN
cord-001835-0s7ok4uw	212	9	complex	complex	NN
cord-001835-0s7ok4uw	212	10	with	with	IN
cord-001835-0s7ok4uw	212	11	LptE	LptE	NNP
cord-001835-0s7ok4uw	212	12	from	from	IN
cord-001835-0s7ok4uw	212	13	Shigella	Shigella	NNP
cord-001835-0s7ok4uw	212	14	flexneri	flexneri	NN
cord-001835-0s7ok4uw	212	15	shows	show	VBZ
cord-001835-0s7ok4uw	212	16	a	a	DT
cord-001835-0s7ok4uw	212	17	26	26	CD
cord-001835-0s7ok4uw	212	18	stranded	strand	VBN
cord-001835-0s7ok4uw	212	19	b	b	NN
cord-001835-0s7ok4uw	212	20	-	-	HYPH
cord-001835-0s7ok4uw	212	21	barrel	barrel	NN
cord-001835-0s7ok4uw	212	22	linked	link	VBN
cord-001835-0s7ok4uw	212	23	to	to	IN
cord-001835-0s7ok4uw	212	24	a	a	DT
cord-001835-0s7ok4uw	212	25	periplasmatic	periplasmatic	JJ
cord-001835-0s7ok4uw	212	26	N	n	CD
cord-001835-0s7ok4uw	212	27	-	-	HYPH
cord-001835-0s7ok4uw	212	28	terminal	terminal	JJ
cord-001835-0s7ok4uw	212	29	jelly	jelly	NN
cord-001835-0s7ok4uw	212	30	-	-	HYPH
cord-001835-0s7ok4uw	212	31	roll	roll	NN
cord-001835-0s7ok4uw	212	32	domain	domain	NN
cord-001835-0s7ok4uw	212	33	.	.	.
cord-001835-0s7ok4uw	213	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	213	2	the	the	DT
cord-001835-0s7ok4uw	213	3	homology	homology	NN
cord-001835-0s7ok4uw	213	4	model	model	NN
cord-001835-0s7ok4uw	213	5	structure	structure	NN
cord-001835-0s7ok4uw	213	6	for	for	IN
cord-001835-0s7ok4uw	213	7	LptD	LptD	NNP
cord-001835-0s7ok4uw	213	8	from	from	IN
cord-001835-0s7ok4uw	213	9	Pseudomonas	Pseudomonas	NNP
cord-001835-0s7ok4uw	213	10	shows	show	VBZ
cord-001835-0s7ok4uw	213	11	a	a	DT
cord-001835-0s7ok4uw	213	12	significant	significant	JJ
cord-001835-0s7ok4uw	213	13	difference	difference	NN
cord-001835-0s7ok4uw	213	14	:	:	:
cord-001835-0s7ok4uw	213	15	an	an	DT
cord-001835-0s7ok4uw	213	16	insertion	insertion	NN
cord-001835-0s7ok4uw	213	17	of	of	IN
cord-001835-0s7ok4uw	213	18	around	around	RB
cord-001835-0s7ok4uw	213	19	100	100	CD
cord-001835-0s7ok4uw	213	20	amino	amino	NN
cord-001835-0s7ok4uw	213	21	acids	acid	NNS
cord-001835-0s7ok4uw	213	22	in	in	IN
cord-001835-0s7ok4uw	213	23	the	the	DT
cord-001835-0s7ok4uw	213	24	N	n	CD
cord-001835-0s7ok4uw	213	25	-	-	HYPH
cord-001835-0s7ok4uw	213	26	terminal	terminal	NN
cord-001835-0s7ok4uw	213	27	domain	domain	NN
cord-001835-0s7ok4uw	213	28	.	.	.
cord-001835-0s7ok4uw	214	1	The	the	DT
cord-001835-0s7ok4uw	214	2	results	result	NNS
cord-001835-0s7ok4uw	214	3	of	of	IN
cord-001835-0s7ok4uw	214	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	214	5	attempts	attempt	NNS
cord-001835-0s7ok4uw	214	6	to	to	TO
cord-001835-0s7ok4uw	214	7	purify	purify	VB
cord-001835-0s7ok4uw	214	8	and	and	CC
cord-001835-0s7ok4uw	214	9	characterize	characterize	VB
cord-001835-0s7ok4uw	214	10	this	this	DT
cord-001835-0s7ok4uw	214	11	large	large	JJ
cord-001835-0s7ok4uw	214	12	outer	outer	JJ
cord-001835-0s7ok4uw	214	13	membrane	membrane	NN
cord-001835-0s7ok4uw	214	14	protein	protein	NN
cord-001835-0s7ok4uw	214	15	and	and	CC
cord-001835-0s7ok4uw	214	16	to	to	TO
cord-001835-0s7ok4uw	214	17	determine	determine	VB
cord-001835-0s7ok4uw	214	18	the	the	DT
cord-001835-0s7ok4uw	214	19	binding	binding	JJ
cord-001835-0s7ok4uw	214	20	site	site	NN
cord-001835-0s7ok4uw	214	21	of	of	IN
cord-001835-0s7ok4uw	214	22	the	the	DT
cord-001835-0s7ok4uw	214	23	peptidomimetic	peptidomimetic	JJ
cord-001835-0s7ok4uw	214	24	antibiotic	antibiotic	NN
cord-001835-0s7ok4uw	214	25	will	will	MD
cord-001835-0s7ok4uw	214	26	be	be	VB
cord-001835-0s7ok4uw	214	27	shown	show	VBN
cord-001835-0s7ok4uw	214	28	.	.	.
cord-001835-0s7ok4uw	214	29	 	 	_SP
cord-001835-0s7ok4uw	215	1	The	the	DT
cord-001835-0s7ok4uw	215	2	theory	theory	NN
cord-001835-0s7ok4uw	215	3	of	of	IN
cord-001835-0s7ok4uw	215	4	how	how	WRB
cord-001835-0s7ok4uw	215	5	life	life	NN
cord-001835-0s7ok4uw	215	6	on	on	IN
cord-001835-0s7ok4uw	215	7	Earth	Earth	NNP
cord-001835-0s7ok4uw	215	8	begun	begin	VBN
cord-001835-0s7ok4uw	215	9	still	still	RB
cord-001835-0s7ok4uw	215	10	remains	remain	VBZ
cord-001835-0s7ok4uw	215	11	unclear	unclear	JJ
cord-001835-0s7ok4uw	215	12	.	.	.
cord-001835-0s7ok4uw	216	1	Nevertheless	nevertheless	RB
cord-001835-0s7ok4uw	216	2	,	,	,
cord-001835-0s7ok4uw	216	3	according	accord	VBG
cord-001835-0s7ok4uw	216	4	to	to	IN
cord-001835-0s7ok4uw	216	5	some	some	DT
cord-001835-0s7ok4uw	216	6	theories	theory	NNS
cord-001835-0s7ok4uw	216	7	,	,	,
cord-001835-0s7ok4uw	216	8	at	at	IN
cord-001835-0s7ok4uw	216	9	the	the	DT
cord-001835-0s7ok4uw	216	10	beginning	beginning	NN
cord-001835-0s7ok4uw	216	11	level	level	NN
cord-001835-0s7ok4uw	216	12	proteins	protein	NNS
cord-001835-0s7ok4uw	216	13	did	do	VBD
cord-001835-0s7ok4uw	216	14	not	not	RB
cord-001835-0s7ok4uw	216	15	emerge	emerge	VB
cord-001835-0s7ok4uw	216	16	as	as	IN
cord-001835-0s7ok4uw	216	17	a	a	DT
cord-001835-0s7ok4uw	216	18	complex	complex	JJ
cord-001835-0s7ok4uw	216	19	globular	globular	JJ
cord-001835-0s7ok4uw	216	20	forms	form	NNS
cord-001835-0s7ok4uw	216	21	as	as	IN
cord-001835-0s7ok4uw	216	22	know	know	VBP
cord-001835-0s7ok4uw	216	23	today	today	NN
cord-001835-0s7ok4uw	216	24	.	.	.
cord-001835-0s7ok4uw	217	1	At	at	IN
cord-001835-0s7ok4uw	217	2	the	the	DT
cord-001835-0s7ok4uw	217	3	times	time	NNS
cord-001835-0s7ok4uw	217	4	,	,	,
cord-001835-0s7ok4uw	217	5	when	when	WRB
cord-001835-0s7ok4uw	217	6	solely	solely	RB
cord-001835-0s7ok4uw	217	7	RNA	RNA	NNP
cord-001835-0s7ok4uw	217	8	molecules	molecule	NNS
cord-001835-0s7ok4uw	217	9	stored	store	VBD
cord-001835-0s7ok4uw	217	10	both	both	DT
cord-001835-0s7ok4uw	217	11	genetic	genetic	JJ
cord-001835-0s7ok4uw	217	12	information	information	NN
cord-001835-0s7ok4uw	217	13	and	and	CC
cord-001835-0s7ok4uw	217	14	catalyzed	catalyze	VBD
cord-001835-0s7ok4uw	217	15	the	the	DT
cord-001835-0s7ok4uw	217	16	chemical	chemical	JJ
cord-001835-0s7ok4uw	217	17	reactions	reaction	NNS
cord-001835-0s7ok4uw	217	18	in	in	IN
cord-001835-0s7ok4uw	217	19	primitive	primitive	JJ
cord-001835-0s7ok4uw	217	20	cells	cell	NNS
cord-001835-0s7ok4uw	217	21	,	,	,
cord-001835-0s7ok4uw	217	22	peptides	peptide	NNS
cord-001835-0s7ok4uw	217	23	acted	act	VBD
cord-001835-0s7ok4uw	217	24	as	as	IN
cord-001835-0s7ok4uw	217	25	a	a	DT
cord-001835-0s7ok4uw	217	26	proteins	protein	NNS
cord-001835-0s7ok4uw	217	27	nowadays	nowadays	RB
cord-001835-0s7ok4uw	217	28	[	[	-LRB-
cord-001835-0s7ok4uw	217	29	1	1	CD
cord-001835-0s7ok4uw	217	30	,	,	,
cord-001835-0s7ok4uw	217	31	2	2	CD
cord-001835-0s7ok4uw	217	32	]	]	-RRB-
cord-001835-0s7ok4uw	217	33	.	.	.
cord-001835-0s7ok4uw	218	1	Literature	literature	NN
cord-001835-0s7ok4uw	218	2	postulate	postulate	VBP
cord-001835-0s7ok4uw	218	3	that	that	IN
cord-001835-0s7ok4uw	218	4	the	the	DT
cord-001835-0s7ok4uw	218	5	possible	possible	JJ
cord-001835-0s7ok4uw	218	6	role	role	NN
cord-001835-0s7ok4uw	218	7	of	of	IN
cord-001835-0s7ok4uw	218	8	primordial	primordial	JJ
cord-001835-0s7ok4uw	218	9	short	short	JJ
cord-001835-0s7ok4uw	218	10	peptides	peptide	NNS
cord-001835-0s7ok4uw	218	11	was	be	VBD
cord-001835-0s7ok4uw	218	12	to	to	TO
cord-001835-0s7ok4uw	218	13	catalyze	catalyze	VB
cord-001835-0s7ok4uw	218	14	reactions	reaction	NNS
cord-001835-0s7ok4uw	218	15	in	in	IN
cord-001835-0s7ok4uw	218	16	RNA	rna	NN
cord-001835-0s7ok4uw	218	17	-	-	HYPH
cord-001835-0s7ok4uw	218	18	world	world	NN
cord-001835-0s7ok4uw	218	19	,	,	,
cord-001835-0s7ok4uw	218	20	as	as	IN
cord-001835-0s7ok4uw	218	21	they	-PRON-	PRP
cord-001835-0s7ok4uw	218	22	possess	possess	VBP
cord-001835-0s7ok4uw	218	23	an	an	DT
cord-001835-0s7ok4uw	218	24	excellent	excellent	JJ
cord-001835-0s7ok4uw	218	25	ability	ability	NN
cord-001835-0s7ok4uw	218	26	to	to	TO
cord-001835-0s7ok4uw	218	27	self	self	NN
cord-001835-0s7ok4uw	218	28	-	-	HYPH
cord-001835-0s7ok4uw	218	29	assemble	assemble	VB
cord-001835-0s7ok4uw	218	30	into	into	IN
cord-001835-0s7ok4uw	218	31	well	well	RB
cord-001835-0s7ok4uw	218	32	-	-	HYPH
cord-001835-0s7ok4uw	218	33	ordered	order	VBN
cord-001835-0s7ok4uw	218	34	nanostructures	nanostructure	NNS
cord-001835-0s7ok4uw	218	35	[	[	-LRB-
cord-001835-0s7ok4uw	218	36	3	3	CD
cord-001835-0s7ok4uw	218	37	,	,	,
cord-001835-0s7ok4uw	218	38	4	4	CD
cord-001835-0s7ok4uw	218	39	]	]	-RRB-
cord-001835-0s7ok4uw	218	40	.	.	.
cord-001835-0s7ok4uw	219	1	Elementary	Elementary	NNP
cord-001835-0s7ok4uw	219	2	Functional	Functional	NNP
cord-001835-0s7ok4uw	219	3	Loops	Loops	NNP
cord-001835-0s7ok4uw	219	4	(	(	-LRB-
cord-001835-0s7ok4uw	219	5	EFLs	efl	NNS
cord-001835-0s7ok4uw	219	6	)	)	-RRB-
cord-001835-0s7ok4uw	219	7	can	can	MD
cord-001835-0s7ok4uw	219	8	be	be	VB
cord-001835-0s7ok4uw	219	9	considered	consider	VBN
cord-001835-0s7ok4uw	219	10	as	as	IN
cord-001835-0s7ok4uw	219	11	a	a	DT
cord-001835-0s7ok4uw	219	12	small	small	JJ
cord-001835-0s7ok4uw	219	13	structures	structure	NNS
cord-001835-0s7ok4uw	219	14	(	(	-LRB-
cord-001835-0s7ok4uw	219	15	blocks	block	NNS
cord-001835-0s7ok4uw	219	16	)	)	-RRB-
cord-001835-0s7ok4uw	219	17	having	have	VBG
cord-001835-0s7ok4uw	219	18	specific	specific	JJ
cord-001835-0s7ok4uw	219	19	signatures	signature	NNS
cord-001835-0s7ok4uw	219	20	and	and	CC
cord-001835-0s7ok4uw	219	21	providing	provide	VBG
cord-001835-0s7ok4uw	219	22	functional	functional	JJ
cord-001835-0s7ok4uw	219	23	residues	residue	NNS
cord-001835-0s7ok4uw	219	24	important	important	JJ
cord-001835-0s7ok4uw	219	25	for	for	IN
cord-001835-0s7ok4uw	219	26	binding	bind	VBG
cord-001835-0s7ok4uw	219	27	/	/	SYM
cord-001835-0s7ok4uw	219	28	activation	activation	NN
cord-001835-0s7ok4uw	219	29	as	as	RB
cord-001835-0s7ok4uw	219	30	well	well	RB
cord-001835-0s7ok4uw	219	31	as	as	IN
cord-001835-0s7ok4uw	219	32	principal	principal	JJ
cord-001835-0s7ok4uw	219	33	chemical	chemical	NN
cord-001835-0s7ok4uw	219	34	transformation	transformation	NN
cord-001835-0s7ok4uw	219	35	steps	step	NNS
cord-001835-0s7ok4uw	219	36	of	of	IN
cord-001835-0s7ok4uw	219	37	the	the	DT
cord-001835-0s7ok4uw	219	38	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	219	39	reaction	reaction	NN
cord-001835-0s7ok4uw	219	40	[	[	-LRB-
cord-001835-0s7ok4uw	219	41	5	5	CD
cord-001835-0s7ok4uw	219	42	]	]	-RRB-
cord-001835-0s7ok4uw	219	43	.	.	.
cord-001835-0s7ok4uw	220	1	P	p	NN
cord-001835-0s7ok4uw	220	2	-	-	HYPH
cord-001835-0s7ok4uw	220	3	Loop	loop	NN
cord-001835-0s7ok4uw	220	4	EFL	EFL	NNP
cord-001835-0s7ok4uw	220	5	is	be	VBZ
cord-001835-0s7ok4uw	220	6	a	a	DT
cord-001835-0s7ok4uw	220	7	widespread	widespread	JJ
cord-001835-0s7ok4uw	220	8	structure	structure	NN
cord-001835-0s7ok4uw	220	9	across	across	IN
cord-001835-0s7ok4uw	220	10	vast	vast	JJ
cord-001835-0s7ok4uw	220	11	majority	majority	NN
cord-001835-0s7ok4uw	220	12	of	of	IN
cord-001835-0s7ok4uw	220	13	protein	protein	NN
cord-001835-0s7ok4uw	220	14	families	family	NNS
cord-001835-0s7ok4uw	220	15	such	such	JJ
cord-001835-0s7ok4uw	220	16	as	as	IN
cord-001835-0s7ok4uw	220	17	motor	motor	NN
cord-001835-0s7ok4uw	220	18	domains	domain	NNS
cord-001835-0s7ok4uw	220	19	,	,	,
cord-001835-0s7ok4uw	220	20	AAA1	AAA1	NNP
cord-001835-0s7ok4uw	220	21	,	,	,
cord-001835-0s7ok4uw	220	22	RecA	RecA	NNP
cord-001835-0s7ok4uw	220	23	,	,	,
cord-001835-0s7ok4uw	220	24	PEPCK	PEPCK	NNP
cord-001835-0s7ok4uw	220	25	and	and	CC
cord-001835-0s7ok4uw	220	26	many	many	JJ
cord-001835-0s7ok4uw	220	27	others	other	NNS
cord-001835-0s7ok4uw	220	28	.	.	.
cord-001835-0s7ok4uw	221	1	Sequential	sequential	JJ
cord-001835-0s7ok4uw	221	2	alignment	alignment	NN
cord-001835-0s7ok4uw	221	3	of	of	IN
cord-001835-0s7ok4uw	221	4	these	these	DT
cord-001835-0s7ok4uw	221	5	protein	protein	NN
cord-001835-0s7ok4uw	221	6	families	family	NNS
cord-001835-0s7ok4uw	221	7	reveals	reveal	VBZ
cord-001835-0s7ok4uw	221	8	existence	existence	NN
cord-001835-0s7ok4uw	221	9	of	of	IN
cord-001835-0s7ok4uw	221	10	a	a	DT
cord-001835-0s7ok4uw	221	11	conserved	conserved	JJ
cord-001835-0s7ok4uw	221	12	P	p	NN
cord-001835-0s7ok4uw	221	13	-	-	HYPH
cord-001835-0s7ok4uw	221	14	loop	loop	NN
cord-001835-0s7ok4uw	221	15	motif	motif	NN
cord-001835-0s7ok4uw	221	16	,	,	,
cord-001835-0s7ok4uw	221	17	that	that	WDT
cord-001835-0s7ok4uw	221	18	is	be	VBZ
cord-001835-0s7ok4uw	221	19	able	able	JJ
cord-001835-0s7ok4uw	221	20	to	to	TO
cord-001835-0s7ok4uw	221	21	bind	bind	VB
cord-001835-0s7ok4uw	221	22	ATP	ATP	NNP
cord-001835-0s7ok4uw	221	23	molecule	molecule	NN
cord-001835-0s7ok4uw	221	24	.	.	.
cord-001835-0s7ok4uw	222	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	222	2	investigated	investigate	VBD
cord-001835-0s7ok4uw	222	3	the	the	DT
cord-001835-0s7ok4uw	222	4	structure	structure	NN
cord-001835-0s7ok4uw	222	5	and	and	CC
cord-001835-0s7ok4uw	222	6	ATPase	ATPase	NNP
cord-001835-0s7ok4uw	222	7	activity	activity	NN
cord-001835-0s7ok4uw	222	8	of	of	IN
cord-001835-0s7ok4uw	222	9	peptides	peptide	NNS
cord-001835-0s7ok4uw	222	10	,	,	,
cord-001835-0s7ok4uw	222	11	which	which	WDT
cord-001835-0s7ok4uw	222	12	sequences	sequence	NNS
cord-001835-0s7ok4uw	222	13	possessed	possess	VBD
cord-001835-0s7ok4uw	222	14	strongly	strongly	RB
cord-001835-0s7ok4uw	222	15	conserved	conserve	VBN
cord-001835-0s7ok4uw	222	16	GXGK[T	GXGK[T	NNP
cord-001835-0s7ok4uw	222	17	/	/	SYM
cord-001835-0s7ok4uw	222	18	S	s	NN
cord-001835-0s7ok4uw	222	19	]	]	-RRB-
cord-001835-0s7ok4uw	222	20	motif	motif	NN
cord-001835-0s7ok4uw	222	21	from	from	IN
cord-001835-0s7ok4uw	222	22	Ploop	Ploop	NNP
cord-001835-0s7ok4uw	222	23	.	.	.
cord-001835-0s7ok4uw	223	1	The	the	DT
cord-001835-0s7ok4uw	223	2	goal	goal	NN
cord-001835-0s7ok4uw	223	3	of	of	IN
cord-001835-0s7ok4uw	223	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	223	5	work	work	NN
cord-001835-0s7ok4uw	223	6	was	be	VBD
cord-001835-0s7ok4uw	223	7	to	to	TO
cord-001835-0s7ok4uw	223	8	check	check	VB
cord-001835-0s7ok4uw	223	9	if	if	IN
cord-001835-0s7ok4uw	223	10	peptides	peptide	NNS
cord-001835-0s7ok4uw	223	11	corresponding	correspond	VBG
cord-001835-0s7ok4uw	223	12	to	to	IN
cord-001835-0s7ok4uw	223	13	the	the	DT
cord-001835-0s7ok4uw	223	14	most	most	RBS
cord-001835-0s7ok4uw	223	15	conserved	conserved	JJ
cord-001835-0s7ok4uw	223	16	P	p	NN
cord-001835-0s7ok4uw	223	17	-	-	HYPH
cord-001835-0s7ok4uw	223	18	loop	loop	NN
cord-001835-0s7ok4uw	223	19	motif	motif	NN
cord-001835-0s7ok4uw	223	20	fragment	fragment	NN
cord-001835-0s7ok4uw	223	21	are	be	VBP
cord-001835-0s7ok4uw	223	22	able	able	JJ
cord-001835-0s7ok4uw	223	23	to	to	TO
cord-001835-0s7ok4uw	223	24	bind	bind	VB
cord-001835-0s7ok4uw	223	25	and	and	CC
cord-001835-0s7ok4uw	223	26	hydrolyze	hydrolyze	VB
cord-001835-0s7ok4uw	223	27	ATP	ATP	NNP
cord-001835-0s7ok4uw	223	28	molecule	molecule	NN
cord-001835-0s7ok4uw	223	29	.	.	.
cord-001835-0s7ok4uw	224	1	All	all	DT
cord-001835-0s7ok4uw	224	2	peptides	peptide	NNS
cord-001835-0s7ok4uw	224	3	under	under	IN
cord-001835-0s7ok4uw	224	4	study	study	NN
cord-001835-0s7ok4uw	224	5	were	be	VBD
cord-001835-0s7ok4uw	224	6	chemically	chemically	RB
cord-001835-0s7ok4uw	224	7	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	224	8	and	and	CC
cord-001835-0s7ok4uw	224	9	their	-PRON-	PRP$
cord-001835-0s7ok4uw	224	10	structures	structure	NNS
cord-001835-0s7ok4uw	224	11	was	be	VBD
cord-001835-0s7ok4uw	224	12	investigated	investigate	VBN
cord-001835-0s7ok4uw	224	13	by	by	IN
cord-001835-0s7ok4uw	224	14	NMR	NMR	NNP
cord-001835-0s7ok4uw	224	15	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	224	16	.	.	.
cord-001835-0s7ok4uw	225	1	The	the	DT
cord-001835-0s7ok4uw	225	2	ability	ability	NN
cord-001835-0s7ok4uw	225	3	to	to	TO
cord-001835-0s7ok4uw	225	4	bind	bind	VB
cord-001835-0s7ok4uw	225	5	ATP	ATP	NNP
cord-001835-0s7ok4uw	225	6	molecules	molecule	NNS
cord-001835-0s7ok4uw	225	7	was	be	VBD
cord-001835-0s7ok4uw	225	8	analyzed	analyze	VBN
cord-001835-0s7ok4uw	225	9	by	by	IN
cord-001835-0s7ok4uw	225	10	using	use	VBG
cord-001835-0s7ok4uw	225	11	HPLC	HPLC	NNP
cord-001835-0s7ok4uw	225	12	chromatography	chromatography	NN
cord-001835-0s7ok4uw	225	13	.	.	.
cord-001835-0s7ok4uw	226	1	Results	result	NNS
cord-001835-0s7ok4uw	226	2	of	of	IN
cord-001835-0s7ok4uw	226	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	226	4	study	study	NN
cord-001835-0s7ok4uw	226	5	show	show	NN
cord-001835-0s7ok4uw	226	6	,	,	,
cord-001835-0s7ok4uw	226	7	that	that	IN
cord-001835-0s7ok4uw	226	8	peptides	peptide	NNS
cord-001835-0s7ok4uw	226	9	with	with	IN
cord-001835-0s7ok4uw	226	10	conserved	conserved	JJ
cord-001835-0s7ok4uw	226	11	P	p	NN
cord-001835-0s7ok4uw	226	12	-	-	HYPH
cord-001835-0s7ok4uw	226	13	Loop	loop	NN
cord-001835-0s7ok4uw	226	14	motif	motif	NN
cord-001835-0s7ok4uw	226	15	have	have	VBP
cord-001835-0s7ok4uw	226	16	a	a	DT
cord-001835-0s7ok4uw	226	17	suitable	suitable	JJ
cord-001835-0s7ok4uw	226	18	structures	structure	NNS
cord-001835-0s7ok4uw	226	19	to	to	TO
cord-001835-0s7ok4uw	226	20	promote	promote	VB
cord-001835-0s7ok4uw	226	21	binding	binding	NN
cord-001835-0s7ok4uw	226	22	of	of	IN
cord-001835-0s7ok4uw	226	23	the	the	DT
cord-001835-0s7ok4uw	226	24	molecules	molecule	NNS
cord-001835-0s7ok4uw	226	25	with	with	IN
cord-001835-0s7ok4uw	226	26	phosphate	phosphate	NN
cord-001835-0s7ok4uw	226	27	group	group	NN
cord-001835-0s7ok4uw	226	28	,	,	,
cord-001835-0s7ok4uw	226	29	but	but	CC
cord-001835-0s7ok4uw	226	30	can	can	MD
cord-001835-0s7ok4uw	226	31	not	not	RB
cord-001835-0s7ok4uw	226	32	accelerate	accelerate	VB
cord-001835-0s7ok4uw	226	33	pyrophosphate	pyrophosphate	NN
cord-001835-0s7ok4uw	226	34	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	226	35	process	process	NN
cord-001835-0s7ok4uw	226	36	.	.	.
cord-001835-0s7ok4uw	227	1	Conference	conference	NN
cord-001835-0s7ok4uw	227	2	participation	participation	NN
cord-001835-0s7ok4uw	227	3	for	for	IN
cord-001835-0s7ok4uw	227	4	W.	W.	NNP
cord-001835-0s7ok4uw	227	5	_	_	NNP
cord-001835-0s7ok4uw	227	6	Z.	Z.	NNP
cord-001835-0s7ok4uw	227	7	supported	support	VBN
cord-001835-0s7ok4uw	227	8	by	by	IN
cord-001835-0s7ok4uw	227	9	the	the	DT
cord-001835-0s7ok4uw	227	10	FP7	FP7	NNP
cord-001835-0s7ok4uw	227	11	project	project	NN
cord-001835-0s7ok4uw	227	12	MOBI4Health	MOBI4Health	.
cord-001835-0s7ok4uw	228	1	(	(	-LRB-
cord-001835-0s7ok4uw	228	2	grant	grant	NN
cord-001835-0s7ok4uw	228	3	agreement	agreement	NN
cord-001835-0s7ok4uw	228	4	no	no	DT
cord-001835-0s7ok4uw	228	5	316094	316094	CD
cord-001835-0s7ok4uw	228	6	)	)	-RRB-
cord-001835-0s7ok4uw	228	7	.	.	.
cord-001835-0s7ok4uw	229	1	Computational	computational	JJ
cord-001835-0s7ok4uw	229	2	resources	resource	NNS
cord-001835-0s7ok4uw	229	3	were	be	VBD
cord-001835-0s7ok4uw	229	4	provided	provide	VBN
cord-001835-0s7ok4uw	229	5	by	by	IN
cord-001835-0s7ok4uw	229	6	the	the	DT
cord-001835-0s7ok4uw	229	7	Informatics	Informatics	NNP
cord-001835-0s7ok4uw	229	8	Center	Center	NNP
cord-001835-0s7ok4uw	229	9	of	of	IN
cord-001835-0s7ok4uw	229	10	the	the	DT
cord-001835-0s7ok4uw	229	11	Metropolitan	Metropolitan	NNP
cord-001835-0s7ok4uw	229	12	Academic	Academic	NNP
cord-001835-0s7ok4uw	229	13	Network	Network	NNP
cord-001835-0s7ok4uw	229	14	(	(	-LRB-
cord-001835-0s7ok4uw	229	15	IC	IC	NNP
cord-001835-0s7ok4uw	229	16	MAN	MAN	NNP
cord-001835-0s7ok4uw	229	17	TASK	TASK	NNP
cord-001835-0s7ok4uw	229	18	)	)	-RRB-
cord-001835-0s7ok4uw	229	19	in	in	IN
cord-001835-0s7ok4uw	229	20	Gdansk	Gdansk	NNP
cord-001835-0s7ok4uw	229	21	,	,	,
cord-001835-0s7ok4uw	229	22	Poland	Poland	NNP
cord-001835-0s7ok4uw	229	23	.	.	.
cord-001835-0s7ok4uw	229	24	 	 	_SP
cord-001835-0s7ok4uw	230	1	CK2	CK2	NNP
cord-001835-0s7ok4uw	230	2	is	be	VBZ
cord-001835-0s7ok4uw	230	3	a	a	DT
cord-001835-0s7ok4uw	230	4	ubiquitous	ubiquitous	JJ
cord-001835-0s7ok4uw	230	5	serine	serine	NN
cord-001835-0s7ok4uw	230	6	/	/	SYM
cord-001835-0s7ok4uw	230	7	threonine	threonine	NN
cord-001835-0s7ok4uw	230	8	protein	protein	NN
cord-001835-0s7ok4uw	230	9	kinase	kinase	NN
cord-001835-0s7ok4uw	230	10	,	,	,
cord-001835-0s7ok4uw	230	11	being	be	VBG
cord-001835-0s7ok4uw	230	12	one	one	CD
cord-001835-0s7ok4uw	230	13	of	of	IN
cord-001835-0s7ok4uw	230	14	the	the	DT
cord-001835-0s7ok4uw	230	15	most	most	RBS
cord-001835-0s7ok4uw	230	16	pleiotropic	pleiotropic	JJ
cord-001835-0s7ok4uw	230	17	of	of	IN
cord-001835-0s7ok4uw	230	18	all	all	DT
cord-001835-0s7ok4uw	230	19	protein	protein	NN
cord-001835-0s7ok4uw	230	20	kinases1	kinases1	NN
cord-001835-0s7ok4uw	230	21	.	.	.
cord-001835-0s7ok4uw	231	1	CK2	CK2	NNP
cord-001835-0s7ok4uw	231	2	plays	play	VBZ
cord-001835-0s7ok4uw	231	3	a	a	DT
cord-001835-0s7ok4uw	231	4	key	key	JJ
cord-001835-0s7ok4uw	231	5	role	role	NN
cord-001835-0s7ok4uw	231	6	in	in	IN
cord-001835-0s7ok4uw	231	7	cell	cell	NN
cord-001835-0s7ok4uw	231	8	growth	growth	NN
cord-001835-0s7ok4uw	231	9	,	,	,
cord-001835-0s7ok4uw	231	10	differentiation	differentiation	NN
cord-001835-0s7ok4uw	231	11	,	,	,
cord-001835-0s7ok4uw	231	12	cell	cell	NN
cord-001835-0s7ok4uw	231	13	death	death	NN
cord-001835-0s7ok4uw	231	14	and	and	CC
cord-001835-0s7ok4uw	231	15	survival	survival	NN
cord-001835-0s7ok4uw	231	16	,	,	,
cord-001835-0s7ok4uw	231	17	and	and	CC
cord-001835-0s7ok4uw	231	18	become	become	VB
cord-001835-0s7ok4uw	231	19	the	the	DT
cord-001835-0s7ok4uw	231	20	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	231	21	target	target	NN
cord-001835-0s7ok4uw	231	22	in	in	IN
cord-001835-0s7ok4uw	231	23	cancer	cancer	NN
cord-001835-0s7ok4uw	231	24	treatment	treatment	NN
cord-001835-0s7ok4uw	231	25	,	,	,
cord-001835-0s7ok4uw	231	26	since	since	IN
cord-001835-0s7ok4uw	231	27	its	-PRON-	PRP$
cord-001835-0s7ok4uw	231	28	level	level	NN
cord-001835-0s7ok4uw	231	29	is	be	VBZ
cord-001835-0s7ok4uw	231	30	significantly	significantly	RB
cord-001835-0s7ok4uw	231	31	increased	increase	VBN
cord-001835-0s7ok4uw	231	32	in	in	IN
cord-001835-0s7ok4uw	231	33	cancer	cancer	NN
cord-001835-0s7ok4uw	231	34	cells2	cells2	NN
cord-001835-0s7ok4uw	231	35	.	.	.
cord-001835-0s7ok4uw	232	1	Halogenated	halogenated	JJ
cord-001835-0s7ok4uw	232	2	ligands	ligand	NNS
cord-001835-0s7ok4uw	232	3	have	have	VBP
cord-001835-0s7ok4uw	232	4	been	be	VBN
cord-001835-0s7ok4uw	232	5	widely	widely	RB
cord-001835-0s7ok4uw	232	6	developed	develop	VBN
cord-001835-0s7ok4uw	232	7	as	as	IN
cord-001835-0s7ok4uw	232	8	potent	potent	JJ
cord-001835-0s7ok4uw	232	9	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	232	10	of	of	IN
cord-001835-0s7ok4uw	232	11	protein	protein	NN
cord-001835-0s7ok4uw	232	12	kinases	kinase	NNS
cord-001835-0s7ok4uw	232	13	.	.	.
cord-001835-0s7ok4uw	233	1	Among	among	IN
cord-001835-0s7ok4uw	233	2	them	-PRON-	PRP
cord-001835-0s7ok4uw	233	3	4,5,6,7-tetrabromobenzoteriazole	4,5,6,7-tetrabromobenzoteriazole	.
cord-001835-0s7ok4uw	234	1	(	(	-LRB-
cord-001835-0s7ok4uw	234	2	TBBt	TBBt	NNP
cord-001835-0s7ok4uw	234	3	)	)	-RRB-
cord-001835-0s7ok4uw	234	4	is	be	VBZ
cord-001835-0s7ok4uw	234	5	one	one	CD
cord-001835-0s7ok4uw	234	6	of	of	IN
cord-001835-0s7ok4uw	234	7	the	the	DT
cord-001835-0s7ok4uw	234	8	first	first	JJ
cord-001835-0s7ok4uw	234	9	potent	potent	JJ
cord-001835-0s7ok4uw	234	10	and	and	CC
cord-001835-0s7ok4uw	234	11	selective	selective	JJ
cord-001835-0s7ok4uw	234	12	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	234	13	of	of	IN
cord-001835-0s7ok4uw	234	14	CK2a	CK2a	NNP
cord-001835-0s7ok4uw	234	15	,	,	,
cord-001835-0s7ok4uw	234	16	directed	direct	VBN
cord-001835-0s7ok4uw	234	17	towards	towards	IN
cord-001835-0s7ok4uw	234	18	the	the	DT
cord-001835-0s7ok4uw	234	19	conserved	conserve	VBN
cord-001835-0s7ok4uw	234	20	ATP	ATP	NNP
cord-001835-0s7ok4uw	234	21	binding	bind	VBG
cord-001835-0s7ok4uw	234	22	site3	site3	NN
cord-001835-0s7ok4uw	234	23	.	.	.
cord-001835-0s7ok4uw	235	1	To	to	TO
cord-001835-0s7ok4uw	235	2	assess	assess	VB
cord-001835-0s7ok4uw	235	3	contribution	contribution	NN
cord-001835-0s7ok4uw	235	4	of	of	IN
cord-001835-0s7ok4uw	235	5	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	235	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	235	7	to	to	IN
cord-001835-0s7ok4uw	235	8	the	the	DT
cord-001835-0s7ok4uw	235	9	specificity	specificity	NN
cord-001835-0s7ok4uw	235	10	and	and	CC
cord-001835-0s7ok4uw	235	11	strength	strength	NN
cord-001835-0s7ok4uw	235	12	of	of	IN
cord-001835-0s7ok4uw	235	13	binding	binding	NN
cord-001835-0s7ok4uw	235	14	of	of	IN
cord-001835-0s7ok4uw	235	15	multi	multi	JJ
cord-001835-0s7ok4uw	235	16	halogenated	halogenated	JJ
cord-001835-0s7ok4uw	235	17	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	235	18	by	by	IN
cord-001835-0s7ok4uw	235	19	a	a	DT
cord-001835-0s7ok4uw	235	20	protein	protein	NN
cord-001835-0s7ok4uw	235	21	kinase	kinase	NN
cord-001835-0s7ok4uw	235	22	,	,	,
cord-001835-0s7ok4uw	235	23	we	-PRON-	PRP
cord-001835-0s7ok4uw	235	24	have	have	VBP
cord-001835-0s7ok4uw	235	25	studied	study	VBN
cord-001835-0s7ok4uw	235	26	interaction	interaction	NN
cord-001835-0s7ok4uw	235	27	between	between	IN
cord-001835-0s7ok4uw	235	28	CK2a	CK2a	NNP
cord-001835-0s7ok4uw	235	29	and	and	CC
cord-001835-0s7ok4uw	235	30	nine	nine	CD
cord-001835-0s7ok4uw	235	31	benzotriazole	benzotriazole	NNP
cord-001835-0s7ok4uw	235	32	derivatives	derivative	NNS
cord-001835-0s7ok4uw	235	33	,	,	,
cord-001835-0s7ok4uw	235	34	representing	represent	VBG
cord-001835-0s7ok4uw	235	35	all	all	DT
cord-001835-0s7ok4uw	235	36	possible	possible	JJ
cord-001835-0s7ok4uw	235	37	patterns	pattern	NNS
cord-001835-0s7ok4uw	235	38	of	of	IN
cord-001835-0s7ok4uw	235	39	halogenation	halogenation	NN
cord-001835-0s7ok4uw	235	40	on	on	IN
cord-001835-0s7ok4uw	235	41	the	the	DT
cord-001835-0s7ok4uw	235	42	benzene	benzene	NN
cord-001835-0s7ok4uw	235	43	ring	ring	NN
cord-001835-0s7ok4uw	235	44	.	.	.
cord-001835-0s7ok4uw	236	1	Herein	herein	RB
cord-001835-0s7ok4uw	236	2	,	,	,
cord-001835-0s7ok4uw	236	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	236	4	present	present	VBP
cord-001835-0s7ok4uw	236	5	results	result	NNS
cord-001835-0s7ok4uw	236	6	that	that	WDT
cord-001835-0s7ok4uw	236	7	support	support	VBP
cord-001835-0s7ok4uw	236	8	existence	existence	NN
cord-001835-0s7ok4uw	236	9	of	of	IN
cord-001835-0s7ok4uw	236	10	two	two	CD
cord-001835-0s7ok4uw	236	11	alternative	alternative	JJ
cord-001835-0s7ok4uw	236	12	regions	region	NNS
cord-001835-0s7ok4uw	236	13	that	that	WDT
cord-001835-0s7ok4uw	236	14	are	be	VBP
cord-001835-0s7ok4uw	236	15	involved	involve	VBN
cord-001835-0s7ok4uw	236	16	in	in	IN
cord-001835-0s7ok4uw	236	17	ligand	ligand	NN
cord-001835-0s7ok4uw	236	18	binding	binding	NN
cord-001835-0s7ok4uw	236	19	.	.	.
cord-001835-0s7ok4uw	237	1	Aspartic	aspartic	JJ
cord-001835-0s7ok4uw	237	2	acid	acid	NN
cord-001835-0s7ok4uw	237	3	175	175	CD
cord-001835-0s7ok4uw	237	4	is	be	VBZ
cord-001835-0s7ok4uw	237	5	known	know	VBN
cord-001835-0s7ok4uw	237	6	for	for	IN
cord-001835-0s7ok4uw	237	7	its	-PRON-	PRP$
cord-001835-0s7ok4uw	237	8	function	function	NN
cord-001835-0s7ok4uw	237	9	in	in	IN
cord-001835-0s7ok4uw	237	10	coordination	coordination	NN
cord-001835-0s7ok4uw	237	11	of	of	IN
cord-001835-0s7ok4uw	237	12	a	a	DT
cord-001835-0s7ok4uw	237	13	Mg21	Mg21	NNP
cord-001835-0s7ok4uw	237	14	ion	ion	NN
cord-001835-0s7ok4uw	237	15	,	,	,
cord-001835-0s7ok4uw	237	16	which	which	WDT
cord-001835-0s7ok4uw	237	17	is	be	VBZ
cord-001835-0s7ok4uw	237	18	required	require	VBN
cord-001835-0s7ok4uw	237	19	for	for	IN
cord-001835-0s7ok4uw	237	20	ATP	ATP	NNP
cord-001835-0s7ok4uw	237	21	binding	bind	VBG
cord-001835-0s7ok4uw	237	22	4	4	CD
cord-001835-0s7ok4uw	237	23	.	.	.
cord-001835-0s7ok4uw	238	1	Asp175	Asp175	NNP
cord-001835-0s7ok4uw	238	2	has	have	VBZ
cord-001835-0s7ok4uw	238	3	been	be	VBN
cord-001835-0s7ok4uw	238	4	identified	identify	VBN
cord-001835-0s7ok4uw	238	5	in	in	IN
cord-001835-0s7ok4uw	238	6	crystal	crystal	JJ
cord-001835-0s7ok4uw	238	7	structure	structure	NN
cord-001835-0s7ok4uw	238	8	of	of	IN
cord-001835-0s7ok4uw	238	9	CK2	CK2	NNP
cord-001835-0s7ok4uw	238	10	:	:	:
cord-001835-0s7ok4uw	238	11	TBBt	TBBt	NNP
cord-001835-0s7ok4uw	238	12	complex	complex	JJ
cord-001835-0s7ok4uw	238	13	(	(	-LRB-
cord-001835-0s7ok4uw	238	14	PDB1j91	PDB1j91	NNP
cord-001835-0s7ok4uw	238	15	,	,	,
cord-001835-0s7ok4uw	238	16	Fig	Fig	NNP
cord-001835-0s7ok4uw	238	17	.	.	NNP
cord-001835-0s7ok4uw	238	18	1	1	CD
cord-001835-0s7ok4uw	238	19	)	)	-RRB-
cord-001835-0s7ok4uw	238	20	as	as	IN
cord-001835-0s7ok4uw	238	21	the	the	DT
cord-001835-0s7ok4uw	238	22	charged	charged	JJ
cord-001835-0s7ok4uw	238	23	residue	residue	NN
cord-001835-0s7ok4uw	238	24	closest	close	JJS
cord-001835-0s7ok4uw	238	25	to	to	IN
cord-001835-0s7ok4uw	238	26	TBBt	TBBt	NNS
cord-001835-0s7ok4uw	238	27	.	.	.
cord-001835-0s7ok4uw	239	1	There	there	EX
cord-001835-0s7ok4uw	239	2	is	be	VBZ
cord-001835-0s7ok4uw	239	3	also	also	RB
cord-001835-0s7ok4uw	239	4	Lys68	Lys68	NNP
cord-001835-0s7ok4uw	239	5	proximal	proximal	JJ
cord-001835-0s7ok4uw	239	6	to	to	IN
cord-001835-0s7ok4uw	239	7	TBBt	TBBt	NNS
cord-001835-0s7ok4uw	239	8	,	,	,
cord-001835-0s7ok4uw	239	9	interaction	interaction	NN
cord-001835-0s7ok4uw	239	10	with	with	IN
cord-001835-0s7ok4uw	239	11	which	which	WDT
cord-001835-0s7ok4uw	239	12	may	may	MD
cord-001835-0s7ok4uw	239	13	favor	favor	VB
cord-001835-0s7ok4uw	239	14	anionic	anionic	JJ
cord-001835-0s7ok4uw	239	15	form	form	NN
cord-001835-0s7ok4uw	239	16	of	of	IN
cord-001835-0s7ok4uw	239	17	ligands5	ligands5	NN
cord-001835-0s7ok4uw	239	18	(	(	-LRB-
cord-001835-0s7ok4uw	239	19	pK	pK	NNP
cord-001835-0s7ok4uw	239	20	for	for	IN
cord-001835-0s7ok4uw	239	21	TBBt	TBBt	NNS
cord-001835-0s7ok4uw	239	22	<	<	XX
cord-001835-0s7ok4uw	239	23	5	5	CD
cord-001835-0s7ok4uw	239	24	)	)	-RRB-
cord-001835-0s7ok4uw	239	25	,	,	,
cord-001835-0s7ok4uw	239	26	however	however	RB
cord-001835-0s7ok4uw	239	27	it	-PRON-	PRP
cord-001835-0s7ok4uw	239	28	is	be	VBZ
cord-001835-0s7ok4uw	239	29	involved	involve	VBN
cord-001835-0s7ok4uw	239	30	in	in	IN
cord-001835-0s7ok4uw	239	31	the	the	DT
cord-001835-0s7ok4uw	239	32	intramolecular	intramolecular	JJ
cord-001835-0s7ok4uw	239	33	salt	salt	NN
cord-001835-0s7ok4uw	239	34	bridge	bridge	NN
cord-001835-0s7ok4uw	239	35	,	,	,
cord-001835-0s7ok4uw	239	36	and	and	CC
cord-001835-0s7ok4uw	239	37	thus	thus	RB
cord-001835-0s7ok4uw	239	38	its	-PRON-	PRP$
cord-001835-0s7ok4uw	239	39	mutation	mutation	NN
cord-001835-0s7ok4uw	239	40	may	may	MD
cord-001835-0s7ok4uw	239	41	significantly	significantly	RB
cord-001835-0s7ok4uw	239	42	change	change	VB
cord-001835-0s7ok4uw	239	43	stability	stability	NN
cord-001835-0s7ok4uw	239	44	of	of	IN
cord-001835-0s7ok4uw	239	45	the	the	DT
cord-001835-0s7ok4uw	239	46	protein	protein	NN
cord-001835-0s7ok4uw	239	47	.	.	.
cord-001835-0s7ok4uw	240	1	Crystal	crystal	NN
cord-001835-0s7ok4uw	240	2	structure	structure	NN
cord-001835-0s7ok4uw	240	3	of	of	IN
cord-001835-0s7ok4uw	240	4	TBBt	TBBt	NNS
cord-001835-0s7ok4uw	240	5	complexed	complexe	VBN
cord-001835-0s7ok4uw	240	6	with	with	IN
cord-001835-0s7ok4uw	240	7	CK2	CK2	NNP
cord-001835-0s7ok4uw	240	8	(	(	-LRB-
cord-001835-0s7ok4uw	240	9	PDB:1j91	pdb:1j91	JJ
cord-001835-0s7ok4uw	240	10	)	)	-RRB-
cord-001835-0s7ok4uw	240	11	.	.	.
cord-001835-0s7ok4uw	241	1	Residues	residue	NNS
cord-001835-0s7ok4uw	241	2	with	with	IN
cord-001835-0s7ok4uw	241	3	a	a	DT
cord-001835-0s7ok4uw	241	4	distance	distance	NN
cord-001835-0s7ok4uw	241	5	to	to	IN
cord-001835-0s7ok4uw	241	6	TBBt	TBBt	NNP
cord-001835-0s7ok4uw	241	7	(	(	-LRB-
cord-001835-0s7ok4uw	241	8	Magenta	magenta	NN
cord-001835-0s7ok4uw	241	9	)	)	-RRB-
cord-001835-0s7ok4uw	241	10	shorter	short	JJR
cord-001835-0s7ok4uw	241	11	than	than	IN
cord-001835-0s7ok4uw	241	12	5A	5a	CD
cord-001835-0s7ok4uw	241	13	are	be	VBP
cord-001835-0s7ok4uw	241	14	shown	show	VBN
cord-001835-0s7ok4uw	241	15	.	.	.
cord-001835-0s7ok4uw	242	1	Red	red	JJ
cord-001835-0s7ok4uw	242	2	residue	residue	NN
cord-001835-0s7ok4uw	242	3	is	be	VBZ
cord-001835-0s7ok4uw	242	4	negatively	negatively	RB
cord-001835-0s7ok4uw	242	5	charged	charge	VBN
cord-001835-0s7ok4uw	242	6	,	,	,
cord-001835-0s7ok4uw	242	7	blue	blue	JJ
cord-001835-0s7ok4uw	242	8	ones	one	NNS
cord-001835-0s7ok4uw	242	9	are	be	VBP
cord-001835-0s7ok4uw	242	10	protonated	protonated	JJ
cord-001835-0s7ok4uw	242	11	.	.	.
cord-001835-0s7ok4uw	243	1	ABSTRACT	abstract	JJ
cord-001835-0s7ok4uw	243	2	Comparison	comparison	NN
cord-001835-0s7ok4uw	243	3	of	of	IN
cord-001835-0s7ok4uw	243	4	Kdiss	Kdiss	NNP
cord-001835-0s7ok4uw	243	5	values	value	NNS
cord-001835-0s7ok4uw	243	6	determined	determine	VBN
cord-001835-0s7ok4uw	243	7	for	for	IN
cord-001835-0s7ok4uw	243	8	ligands	ligand	NNS
cord-001835-0s7ok4uw	243	9	at	at	IN
cord-001835-0s7ok4uw	243	10	pH	pH	NNP
cord-001835-0s7ok4uw	243	11	8	8	CD
cord-001835-0s7ok4uw	243	12	and	and	CC
cord-001835-0s7ok4uw	243	13	at	at	IN
cord-001835-0s7ok4uw	243	14	pH	pH	NNP
cord-001835-0s7ok4uw	243	15	7	7	CD
cord-001835-0s7ok4uw	243	16	shows	show	VBZ
cord-001835-0s7ok4uw	243	17	that	that	DT
cord-001835-0s7ok4uw	243	18	strength	strength	NN
cord-001835-0s7ok4uw	243	19	of	of	IN
cord-001835-0s7ok4uw	243	20	the	the	DT
cord-001835-0s7ok4uw	243	21	complex	complex	NN
cord-001835-0s7ok4uw	243	22	significantly	significantly	RB
cord-001835-0s7ok4uw	243	23	varies	vary	VBZ
cord-001835-0s7ok4uw	243	24	upon	upon	IN
cord-001835-0s7ok4uw	243	25	deprotonation	deprotonation	NN
cord-001835-0s7ok4uw	243	26	of	of	IN
cord-001835-0s7ok4uw	243	27	the	the	DT
cord-001835-0s7ok4uw	243	28	triazole	triazole	NN
cord-001835-0s7ok4uw	243	29	ring	ring	NN
cord-001835-0s7ok4uw	243	30	.	.	.
cord-001835-0s7ok4uw	244	1	This	this	DT
cord-001835-0s7ok4uw	244	2	confirms	confirm	VBZ
cord-001835-0s7ok4uw	244	3	former	former	JJ
cord-001835-0s7ok4uw	244	4	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	244	5	that	that	IN
cord-001835-0s7ok4uw	244	6	a	a	DT
cord-001835-0s7ok4uw	244	7	negatively	negatively	RB
cord-001835-0s7ok4uw	244	8	charged	charge	VBN
cord-001835-0s7ok4uw	244	9	ligands	ligand	NNS
cord-001835-0s7ok4uw	244	10	cluster	cluster	NN
cord-001835-0s7ok4uw	244	11	at	at	IN
cord-001835-0s7ok4uw	244	12	the	the	DT
cord-001835-0s7ok4uw	244	13	ATP	ATP	NNP
cord-001835-0s7ok4uw	244	14	binding	binding	NN
cord-001835-0s7ok4uw	244	15	site	site	NN
cord-001835-0s7ok4uw	244	16	region	region	NN
cord-001835-0s7ok4uw	244	17	proximal	proximal	JJ
cord-001835-0s7ok4uw	244	18	to	to	IN
cord-001835-0s7ok4uw	244	19	Lys685	Lys685	NNP
cord-001835-0s7ok4uw	244	20	,	,	,
cord-001835-0s7ok4uw	244	21	which	which	WDT
cord-001835-0s7ok4uw	244	22	is	be	VBZ
cord-001835-0s7ok4uw	244	23	beneficial	beneficial	JJ
cord-001835-0s7ok4uw	244	24	both	both	DT
cord-001835-0s7ok4uw	244	25	to	to	IN
cord-001835-0s7ok4uw	244	26	the	the	DT
cord-001835-0s7ok4uw	244	27	specificity	specificity	NN
cord-001835-0s7ok4uw	244	28	and	and	CC
cord-001835-0s7ok4uw	244	29	to	to	IN
cord-001835-0s7ok4uw	244	30	strength	strength	NN
cord-001835-0s7ok4uw	244	31	of	of	IN
cord-001835-0s7ok4uw	244	32	the	the	DT
cord-001835-0s7ok4uw	244	33	binding	binding	NN
cord-001835-0s7ok4uw	244	34	.	.	.
cord-001835-0s7ok4uw	245	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	245	2	have	have	VBP
cord-001835-0s7ok4uw	245	3	also	also	RB
cord-001835-0s7ok4uw	245	4	observed	observe	VBN
cord-001835-0s7ok4uw	245	5	for	for	IN
cord-001835-0s7ok4uw	245	6	the	the	DT
cord-001835-0s7ok4uw	245	7	tested	test	VBN
cord-001835-0s7ok4uw	245	8	ligands	ligand	NNS
cord-001835-0s7ok4uw	245	9	variations	variation	NNS
cord-001835-0s7ok4uw	245	10	in	in	IN
cord-001835-0s7ok4uw	245	11	their	-PRON-	PRP$
cord-001835-0s7ok4uw	245	12	binding	binding	NN
cord-001835-0s7ok4uw	245	13	to	to	IN
cord-001835-0s7ok4uw	245	14	either	either	CC
cord-001835-0s7ok4uw	245	15	wild	wild	JJ
cord-001835-0s7ok4uw	245	16	type	type	NN
cord-001835-0s7ok4uw	245	17	protein	protein	NN
cord-001835-0s7ok4uw	245	18	and	and	CC
cord-001835-0s7ok4uw	245	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	245	20	D175N	d175n	NN
cord-001835-0s7ok4uw	245	21	mutant	mutant	NN
cord-001835-0s7ok4uw	245	22	(	(	-LRB-
cord-001835-0s7ok4uw	245	23	with	with	IN
cord-001835-0s7ok4uw	245	24	less	less	RBR
cord-001835-0s7ok4uw	245	25	negative	negative	JJ
cord-001835-0s7ok4uw	245	26	charge	charge	NN
cord-001835-0s7ok4uw	245	27	distributed	distribute	VBN
cord-001835-0s7ok4uw	245	28	over	over	IN
cord-001835-0s7ok4uw	245	29	ATP	ATP	NNP
cord-001835-0s7ok4uw	245	30	binding	binding	NN
cord-001835-0s7ok4uw	245	31	site	site	NN
cord-001835-0s7ok4uw	245	32	)	)	-RRB-
cord-001835-0s7ok4uw	245	33	.	.	.
cord-001835-0s7ok4uw	246	1	All	all	DT
cord-001835-0s7ok4uw	246	2	ligands	ligand	NNS
cord-001835-0s7ok4uw	246	3	displaying	display	VBG
cord-001835-0s7ok4uw	246	4	higher	high	JJR
cord-001835-0s7ok4uw	246	5	pKa	pKa	NNS
cord-001835-0s7ok4uw	246	6	for	for	IN
cord-001835-0s7ok4uw	246	7	dissociation	dissociation	NN
cord-001835-0s7ok4uw	246	8	of	of	IN
cord-001835-0s7ok4uw	246	9	the	the	DT
cord-001835-0s7ok4uw	246	10	triazole	triazole	NNP
cord-001835-0s7ok4uw	246	11	proton	proton	NNP
cord-001835-0s7ok4uw	246	12	bind	bind	NN
cord-001835-0s7ok4uw	246	13	to	to	IN
cord-001835-0s7ok4uw	246	14	the	the	DT
cord-001835-0s7ok4uw	246	15	mutant	mutant	NN
cord-001835-0s7ok4uw	246	16	visibly	visibly	RB
cord-001835-0s7ok4uw	246	17	weaker	weak	JJR
cord-001835-0s7ok4uw	246	18	than	than	IN
cord-001835-0s7ok4uw	246	19	to	to	IN
cord-001835-0s7ok4uw	246	20	the	the	DT
cord-001835-0s7ok4uw	246	21	wild	wild	JJ
cord-001835-0s7ok4uw	246	22	-	-	HYPH
cord-001835-0s7ok4uw	246	23	type	type	NN
cord-001835-0s7ok4uw	246	24	protein	protein	NN
cord-001835-0s7ok4uw	246	25	.	.	.
cord-001835-0s7ok4uw	247	1	Altogether	altogether	RB
cord-001835-0s7ok4uw	247	2	reveals	reveal	VBZ
cord-001835-0s7ok4uw	247	3	the	the	DT
cord-001835-0s7ok4uw	247	4	predominance	predominance	NN
cord-001835-0s7ok4uw	247	5	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	247	6	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	247	7	interactions	interaction	NNS
cord-001835-0s7ok4uw	247	8	.	.	.
cord-001835-0s7ok4uw	248	1	Although	although	IN
cord-001835-0s7ok4uw	248	2	,	,	,
cord-001835-0s7ok4uw	248	3	negatively	negatively	RB
cord-001835-0s7ok4uw	248	4	charged	charge	VBN
cord-001835-0s7ok4uw	248	5	ligands	ligand	NNS
cord-001835-0s7ok4uw	248	6	most	most	RBS
cord-001835-0s7ok4uw	248	7	probably	probably	RB
cord-001835-0s7ok4uw	248	8	cluster	cluster	JJ
cord-001835-0s7ok4uw	248	9	at	at	IN
cord-001835-0s7ok4uw	248	10	the	the	DT
cord-001835-0s7ok4uw	248	11	ATPbinding	atpbinding	NN
cord-001835-0s7ok4uw	248	12	site	site	NN
cord-001835-0s7ok4uw	248	13	proximal	proximal	JJ
cord-001835-0s7ok4uw	248	14	to	to	IN
cord-001835-0s7ok4uw	248	15	Lys68	Lys68	NNP
cord-001835-0s7ok4uw	248	16	,	,	,
cord-001835-0s7ok4uw	248	17	beneficial	beneficial	JJ
cord-001835-0s7ok4uw	248	18	for	for	IN
cord-001835-0s7ok4uw	248	19	the	the	DT
cord-001835-0s7ok4uw	248	20	strength	strength	NN
cord-001835-0s7ok4uw	248	21	of	of	IN
cord-001835-0s7ok4uw	248	22	binding	binding	NN
cord-001835-0s7ok4uw	248	23	,	,	,
cord-001835-0s7ok4uw	248	24	the	the	DT
cord-001835-0s7ok4uw	248	25	less	less	RBR
cord-001835-0s7ok4uw	248	26	dissociated	dissociated	JJ
cord-001835-0s7ok4uw	248	27	forms	form	NNS
cord-001835-0s7ok4uw	248	28	are	be	VBP
cord-001835-0s7ok4uw	248	29	favored	favor	VBN
cord-001835-0s7ok4uw	248	30	due	due	IN
cord-001835-0s7ok4uw	248	31	to	to	IN
cord-001835-0s7ok4uw	248	32	unfavorable	unfavorable	JJ
cord-001835-0s7ok4uw	248	33	interactions	interaction	NNS
cord-001835-0s7ok4uw	248	34	of	of	IN
cord-001835-0s7ok4uw	248	35	the	the	DT
cord-001835-0s7ok4uw	248	36	anionic	anionic	JJ
cord-001835-0s7ok4uw	248	37	form	form	NN
cord-001835-0s7ok4uw	248	38	of	of	IN
cord-001835-0s7ok4uw	248	39	ligands	ligand	NNS
cord-001835-0s7ok4uw	248	40	with	with	IN
cord-001835-0s7ok4uw	248	41	Asp175	asp175	CD
cord-001835-0s7ok4uw	248	42	.	.	.
cord-001835-0s7ok4uw	249	1	1	1	LS
cord-001835-0s7ok4uw	250	1	There	there	EX
cord-001835-0s7ok4uw	250	2	are	be	VBP
cord-001835-0s7ok4uw	250	3	many	many	JJ
cord-001835-0s7ok4uw	250	4	virulence	virulence	NN
cord-001835-0s7ok4uw	250	5	factors	factor	NNS
cord-001835-0s7ok4uw	250	6	produced	produce	VBN
cord-001835-0s7ok4uw	250	7	by	by	IN
cord-001835-0s7ok4uw	250	8	these	these	DT
cord-001835-0s7ok4uw	250	9	strains	strain	NNS
cord-001835-0s7ok4uw	250	10	,	,	,
cord-001835-0s7ok4uw	250	11	many	many	JJ
cord-001835-0s7ok4uw	250	12	of	of	IN
cord-001835-0s7ok4uw	250	13	which	which	WDT
cord-001835-0s7ok4uw	250	14	are	be	VBP
cord-001835-0s7ok4uw	250	15	encoded	encode	VBN
cord-001835-0s7ok4uw	250	16	on	on	IN
cord-001835-0s7ok4uw	250	17	mobile	mobile	JJ
cord-001835-0s7ok4uw	250	18	genetic	genetic	JJ
cord-001835-0s7ok4uw	250	19	elements	element	NNS
cord-001835-0s7ok4uw	250	20	.	.	.
cord-001835-0s7ok4uw	251	1	2	2	CD
cord-001835-0s7ok4uw	251	2	PSMs	psm	NNS
cord-001835-0s7ok4uw	251	3	are	be	VBP
cord-001835-0s7ok4uw	251	4	of	of	IN
cord-001835-0s7ok4uw	251	5	specific	specific	JJ
cord-001835-0s7ok4uw	251	6	interest	interest	NN
cord-001835-0s7ok4uw	251	7	because	because	IN
cord-001835-0s7ok4uw	251	8	these	these	DT
cord-001835-0s7ok4uw	251	9	virulence	virulence	NN
cord-001835-0s7ok4uw	251	10	factors	factor	NNS
cord-001835-0s7ok4uw	251	11	are	be	VBP
cord-001835-0s7ok4uw	251	12	encoded	encode	VBN
cord-001835-0s7ok4uw	251	13	on	on	IN
cord-001835-0s7ok4uw	251	14	the	the	DT
cord-001835-0s7ok4uw	251	15	core	core	NN
cord-001835-0s7ok4uw	251	16	genome	genome	NN
cord-001835-0s7ok4uw	251	17	of	of	IN
cord-001835-0s7ok4uw	251	18	the	the	DT
cord-001835-0s7ok4uw	251	19	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	251	20	and	and	CC
cord-001835-0s7ok4uw	251	21	therefore	therefore	RB
cord-001835-0s7ok4uw	251	22	all	all	DT
cord-001835-0s7ok4uw	251	23	strains	strain	NNS
cord-001835-0s7ok4uw	251	24	of	of	IN
cord-001835-0s7ok4uw	251	25	staphylococci	staphylococcus	NNS
cord-001835-0s7ok4uw	251	26	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	251	27	produce	produce	VBP
cord-001835-0s7ok4uw	251	28	some	some	DT
cord-001835-0s7ok4uw	251	29	variation	variation	NN
cord-001835-0s7ok4uw	251	30	of	of	IN
cord-001835-0s7ok4uw	251	31	PSMs	psm	NNS
cord-001835-0s7ok4uw	251	32	with	with	IN
cord-001835-0s7ok4uw	251	33	a	a	DT
cord-001835-0s7ok4uw	251	34	variety	variety	NN
cord-001835-0s7ok4uw	251	35	of	of	IN
cord-001835-0s7ok4uw	251	36	biological	biological	JJ
cord-001835-0s7ok4uw	251	37	functions	function	NNS
cord-001835-0s7ok4uw	251	38	.	.	.
cord-001835-0s7ok4uw	252	1	2	2	LS
cord-001835-0s7ok4uw	253	1	The	the	DT
cord-001835-0s7ok4uw	253	2	specific	specific	JJ
cord-001835-0s7ok4uw	253	3	mechanism	mechanism	NN
cord-001835-0s7ok4uw	253	4	by	by	IN
cord-001835-0s7ok4uw	253	5	which	which	WDT
cord-001835-0s7ok4uw	253	6	PSMs	psm	NNS
cord-001835-0s7ok4uw	253	7	act	act	NNP
cord-001835-0s7ok4uw	253	8	as	as	IN
cord-001835-0s7ok4uw	253	9	virulence	virulence	NN
cord-001835-0s7ok4uw	253	10	factors	factor	NNS
cord-001835-0s7ok4uw	253	11	has	have	VBZ
cord-001835-0s7ok4uw	253	12	been	be	VBN
cord-001835-0s7ok4uw	253	13	poorly	poorly	RB
cord-001835-0s7ok4uw	253	14	understood	understand	VBN
cord-001835-0s7ok4uw	253	15	until	until	IN
cord-001835-0s7ok4uw	253	16	recently	recently	RB
cord-001835-0s7ok4uw	253	17	.	.	.
cord-001835-0s7ok4uw	254	1	Biological	biological	JJ
cord-001835-0s7ok4uw	254	2	functions	function	NNS
cord-001835-0s7ok4uw	254	3	of	of	IN
cord-001835-0s7ok4uw	254	4	PSMs	psm	NNS
cord-001835-0s7ok4uw	254	5	include	include	VBP
cord-001835-0s7ok4uw	254	6	cell	cell	NN
cord-001835-0s7ok4uw	254	7	lysis	lysis	NN
cord-001835-0s7ok4uw	254	8	,	,	,
cord-001835-0s7ok4uw	254	9	biofilm	biofilm	NN
cord-001835-0s7ok4uw	254	10	formation	formation	NN
cord-001835-0s7ok4uw	254	11	and	and	CC
cord-001835-0s7ok4uw	254	12	the	the	DT
cord-001835-0s7ok4uw	254	13	ability	ability	NN
cord-001835-0s7ok4uw	254	14	to	to	TO
cord-001835-0s7ok4uw	254	15	kill	kill	VB
cord-001835-0s7ok4uw	254	16	neutrophils	neutrophil	NNS
cord-001835-0s7ok4uw	254	17	after	after	IN
cord-001835-0s7ok4uw	254	18	phagocystosis.1	phagocystosis.1	JJ
cord-001835-0s7ok4uw	254	19	These	these	DT
cord-001835-0s7ok4uw	254	20	toxins	toxin	NNS
cord-001835-0s7ok4uw	254	21	are	be	VBP
cord-001835-0s7ok4uw	254	22	of	of	IN
cord-001835-0s7ok4uw	254	23	special	special	JJ
cord-001835-0s7ok4uw	254	24	interest	interest	NN
cord-001835-0s7ok4uw	254	25	to	to	IN
cord-001835-0s7ok4uw	254	26	our	-PRON-	PRP$
cord-001835-0s7ok4uw	254	27	research	research	NN
cord-001835-0s7ok4uw	254	28	group	group	NN
cord-001835-0s7ok4uw	254	29	due	due	IN
cord-001835-0s7ok4uw	254	30	to	to	IN
cord-001835-0s7ok4uw	254	31	their	-PRON-	PRP$
cord-001835-0s7ok4uw	254	32	genetic	genetic	JJ
cord-001835-0s7ok4uw	254	33	similarities	similarity	NNS
cord-001835-0s7ok4uw	254	34	to	to	IN
cord-001835-0s7ok4uw	254	35	certain	certain	JJ
cord-001835-0s7ok4uw	254	36	bacteriocins	bacteriocin	NNS
cord-001835-0s7ok4uw	254	37	,	,	,
cord-001835-0s7ok4uw	254	38	namely	namely	RB
cord-001835-0s7ok4uw	254	39	leaderless	leaderless	JJ
cord-001835-0s7ok4uw	254	40	bacteriocins	bacteriocin	NNS
cord-001835-0s7ok4uw	254	41	.	.	.
cord-001835-0s7ok4uw	255	1	3	3	LS
cord-001835-0s7ok4uw	256	1	Both	both	DT
cord-001835-0s7ok4uw	256	2	groups	group	NNS
cord-001835-0s7ok4uw	256	3	of	of	IN
cord-001835-0s7ok4uw	256	4	peptides	peptide	NNS
cord-001835-0s7ok4uw	256	5	are	be	VBP
cord-001835-0s7ok4uw	256	6	ribosomally	ribosomally	RB
cord-001835-0s7ok4uw	256	7	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	256	8	with	with	IN
cord-001835-0s7ok4uw	256	9	a	a	DT
cord-001835-0s7ok4uw	256	10	N	n	CD
cord-001835-0s7ok4uw	256	11	-	-	HYPH
cord-001835-0s7ok4uw	256	12	terminal	terminal	NN
cord-001835-0s7ok4uw	256	13	formyl	formyl	NNP
cord-001835-0s7ok4uw	256	14	methionine	methionine	NN
cord-001835-0s7ok4uw	256	15	and	and	CC
cord-001835-0s7ok4uw	256	16	secreted	secrete	VBD
cord-001835-0s7ok4uw	256	17	from	from	IN
cord-001835-0s7ok4uw	256	18	the	the	DT
cord-001835-0s7ok4uw	256	19	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	256	20	by	by	IN
cord-001835-0s7ok4uw	256	21	ATP	ATP	NNP
cord-001835-0s7ok4uw	256	22	-	-	HYPH
cord-001835-0s7ok4uw	256	23	binding	bind	VBG
cord-001835-0s7ok4uw	256	24	cassette	cassette	NN
cord-001835-0s7ok4uw	256	25	(	(	-LRB-
cord-001835-0s7ok4uw	256	26	ABC	ABC	NNP
cord-001835-0s7ok4uw	256	27	)	)	-RRB-
cord-001835-0s7ok4uw	256	28	transporters	transporter	NNS
cord-001835-0s7ok4uw	256	29	without	without	IN
cord-001835-0s7ok4uw	256	30	any	any	DT
cord-001835-0s7ok4uw	256	31	leader	leader	NN
cord-001835-0s7ok4uw	256	32	sequence	sequence	NN
cord-001835-0s7ok4uw	256	33	or	or	CC
cord-001835-0s7ok4uw	256	34	signal	signal	NN
cord-001835-0s7ok4uw	256	35	peptide	peptide	NN
cord-001835-0s7ok4uw	256	36	.	.	.
cord-001835-0s7ok4uw	257	1	ABC	ABC	NNP
cord-001835-0s7ok4uw	257	2	transporters	transporter	NNS
cord-001835-0s7ok4uw	257	3	may	may	MD
cord-001835-0s7ok4uw	257	4	also	also	RB
cord-001835-0s7ok4uw	257	5	play	play	VB
cord-001835-0s7ok4uw	257	6	a	a	DT
cord-001835-0s7ok4uw	257	7	role	role	NN
cord-001835-0s7ok4uw	257	8	in	in	IN
cord-001835-0s7ok4uw	257	9	immunity	immunity	NN
cord-001835-0s7ok4uw	257	10	towards	towards	IN
cord-001835-0s7ok4uw	257	11	PSMs	psm	NNS
cord-001835-0s7ok4uw	257	12	and	and	CC
cord-001835-0s7ok4uw	257	13	leaderless	leaderless	JJ
cord-001835-0s7ok4uw	257	14	bacteriocins	bacteriocin	NNS
cord-001835-0s7ok4uw	257	15	.	.	.
cord-001835-0s7ok4uw	258	1	These	these	DT
cord-001835-0s7ok4uw	258	2	similarities	similarity	NNS
cord-001835-0s7ok4uw	258	3	led	lead	VBD
cord-001835-0s7ok4uw	258	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	258	5	group	group	NN
cord-001835-0s7ok4uw	258	6	to	to	TO
cord-001835-0s7ok4uw	258	7	investigate	investigate	VB
cord-001835-0s7ok4uw	258	8	the	the	DT
cord-001835-0s7ok4uw	258	9	solution	solution	NN
cord-001835-0s7ok4uw	258	10	structure	structure	NN
cord-001835-0s7ok4uw	258	11	of	of	IN
cord-001835-0s7ok4uw	258	12	these	these	DT
cord-001835-0s7ok4uw	258	13	peptides	peptide	NNS
cord-001835-0s7ok4uw	258	14	through	through	IN
cord-001835-0s7ok4uw	258	15	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	258	16	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	258	17	resonance	resonance	NN
cord-001835-0s7ok4uw	258	18	(	(	-LRB-
cord-001835-0s7ok4uw	258	19	NMR	NMR	NNP
cord-001835-0s7ok4uw	258	20	)	)	-RRB-
cord-001835-0s7ok4uw	258	21	.	.	.
cord-001835-0s7ok4uw	259	1	Isolating	isolate	VBG
cord-001835-0s7ok4uw	259	2	PSMs	psm	NNS
cord-001835-0s7ok4uw	259	3	from	from	IN
cord-001835-0s7ok4uw	259	4	the	the	DT
cord-001835-0s7ok4uw	259	5	producer	producer	NN
cord-001835-0s7ok4uw	259	6	organisim	organisim	NN
cord-001835-0s7ok4uw	259	7	,	,	,
cord-001835-0s7ok4uw	259	8	S.	S.	NNP
cord-001835-0s7ok4uw	259	9	aureus	aureus	NN
cord-001835-0s7ok4uw	259	10	,	,	,
cord-001835-0s7ok4uw	259	11	typically	typically	RB
cord-001835-0s7ok4uw	259	12	involves	involve	VBZ
cord-001835-0s7ok4uw	259	13	lengthy	lengthy	JJ
cord-001835-0s7ok4uw	259	14	extractions	extraction	NNS
cord-001835-0s7ok4uw	259	15	and	and	CC
cord-001835-0s7ok4uw	259	16	low	low	JJ
cord-001835-0s7ok4uw	259	17	yields	yield	NNS
cord-001835-0s7ok4uw	259	18	.	.	.
cord-001835-0s7ok4uw	260	1	4	4	LS
cord-001835-0s7ok4uw	261	1	For	for	IN
cord-001835-0s7ok4uw	261	2	these	these	DT
cord-001835-0s7ok4uw	261	3	reasons	reason	NNS
cord-001835-0s7ok4uw	261	4	,	,	,
cord-001835-0s7ok4uw	261	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	261	6	opted	opt	VBD
cord-001835-0s7ok4uw	261	7	to	to	TO
cord-001835-0s7ok4uw	261	8	chemically	chemically	RB
cord-001835-0s7ok4uw	261	9	synthesize	synthesize	VB
cord-001835-0s7ok4uw	261	10	the	the	DT
cord-001835-0s7ok4uw	261	11	desired	desire	VBN
cord-001835-0s7ok4uw	261	12	peptides	peptide	NNS
cord-001835-0s7ok4uw	261	13	using	use	VBG
cord-001835-0s7ok4uw	261	14	solid	solid	JJ
cord-001835-0s7ok4uw	261	15	phase	phase	NN
cord-001835-0s7ok4uw	261	16	peptide	peptide	NN
cord-001835-0s7ok4uw	261	17	synthesis	synthesis	NN
cord-001835-0s7ok4uw	261	18	(	(	-LRB-
cord-001835-0s7ok4uw	261	19	SPPS	SPPS	NNP
cord-001835-0s7ok4uw	261	20	)	)	-RRB-
cord-001835-0s7ok4uw	261	21	.	.	.
cord-001835-0s7ok4uw	262	1	Utilizing	utilize	VBG
cord-001835-0s7ok4uw	262	2	a	a	DT
cord-001835-0s7ok4uw	262	3	variety	variety	NN
cord-001835-0s7ok4uw	262	4	of	of	IN
cord-001835-0s7ok4uw	262	5	SPPS	spp	NNS
cord-001835-0s7ok4uw	262	6	techniques	technique	NNS
cord-001835-0s7ok4uw	262	7	,	,	,
cord-001835-0s7ok4uw	262	8	PSM	PSM	NNP
cord-001835-0s7ok4uw	262	9	a1	a1	NNP
cord-001835-0s7ok4uw	262	10	and	and	CC
cord-001835-0s7ok4uw	262	11	PSM	PSM	NNP
cord-001835-0s7ok4uw	262	12	a3	a3	NNP
cord-001835-0s7ok4uw	262	13	were	be	VBD
cord-001835-0s7ok4uw	262	14	successfully	successfully	RB
cord-001835-0s7ok4uw	262	15	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	262	16	,	,	,
cord-001835-0s7ok4uw	262	17	however	however	RB
cord-001835-0s7ok4uw	262	18	,	,	,
cord-001835-0s7ok4uw	262	19	due	due	IN
cord-001835-0s7ok4uw	262	20	to	to	IN
cord-001835-0s7ok4uw	262	21	the	the	DT
cord-001835-0s7ok4uw	262	22	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	262	23	nature	nature	NN
cord-001835-0s7ok4uw	262	24	of	of	IN
cord-001835-0s7ok4uw	262	25	PSM	PSM	NNP
cord-001835-0s7ok4uw	262	26	b2	b2	NN
cord-001835-0s7ok4uw	262	27	,	,	,
cord-001835-0s7ok4uw	262	28	an	an	DT
cord-001835-0s7ok4uw	262	29	alternate	alternate	JJ
cord-001835-0s7ok4uw	262	30	genetic	genetic	JJ
cord-001835-0s7ok4uw	262	31	approach	approach	NN
cord-001835-0s7ok4uw	262	32	was	be	VBD
cord-001835-0s7ok4uw	262	33	devised	devise	VBN
cord-001835-0s7ok4uw	262	34	to	to	TO
cord-001835-0s7ok4uw	262	35	isolate	isolate	VB
cord-001835-0s7ok4uw	262	36	PSM	PSM	NNP
cord-001835-0s7ok4uw	262	37	b2	b2	NN
cord-001835-0s7ok4uw	262	38	.	.	.
cord-001835-0s7ok4uw	263	1	Formation	formation	NN
cord-001835-0s7ok4uw	263	2	of	of	IN
cord-001835-0s7ok4uw	263	3	a	a	DT
cord-001835-0s7ok4uw	263	4	fusion	fusion	NN
cord-001835-0s7ok4uw	263	5	protein	protein	NN
cord-001835-0s7ok4uw	263	6	between	between	IN
cord-001835-0s7ok4uw	263	7	PSM	PSM	NNP
cord-001835-0s7ok4uw	263	8	b2	b2	NN
cord-001835-0s7ok4uw	263	9	and	and	CC
cord-001835-0s7ok4uw	263	10	the	the	DT
cord-001835-0s7ok4uw	263	11	small	small	JJ
cord-001835-0s7ok4uw	263	12	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	263	13	like	like	IN
cord-001835-0s7ok4uw	263	14	modifier	modifier	NN
cord-001835-0s7ok4uw	263	15	(	(	-LRB-
cord-001835-0s7ok4uw	263	16	SUMO	SUMO	NNP
cord-001835-0s7ok4uw	263	17	)	)	-RRB-
cord-001835-0s7ok4uw	263	18	protein	protein	NN
cord-001835-0s7ok4uw	263	19	allowed	allow	VBN
cord-001835-0s7ok4uw	263	20	for	for	IN
cord-001835-0s7ok4uw	263	21	heterologous	heterologous	JJ
cord-001835-0s7ok4uw	263	22	expression	expression	NN
cord-001835-0s7ok4uw	263	23	.	.	.
cord-001835-0s7ok4uw	264	1	Upon	upon	IN
cord-001835-0s7ok4uw	264	2	cleavage	cleavage	NN
cord-001835-0s7ok4uw	264	3	of	of	IN
cord-001835-0s7ok4uw	264	4	the	the	DT
cord-001835-0s7ok4uw	264	5	fusion	fusion	NN
cord-001835-0s7ok4uw	264	6	protein	protein	NN
cord-001835-0s7ok4uw	264	7	with	with	IN
cord-001835-0s7ok4uw	264	8	SUMO	SUMO	NNP
cord-001835-0s7ok4uw	264	9	protease	protease	NN
cord-001835-0s7ok4uw	264	10	,	,	,
cord-001835-0s7ok4uw	264	11	and	and	CC
cord-001835-0s7ok4uw	264	12	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	264	13	purification	purification	NN
cord-001835-0s7ok4uw	264	14	and	and	CC
cord-001835-0s7ok4uw	264	15	isolation	isolation	NN
cord-001835-0s7ok4uw	264	16	of	of	IN
cord-001835-0s7ok4uw	264	17	the	the	DT
cord-001835-0s7ok4uw	264	18	cut	cut	NN
cord-001835-0s7ok4uw	264	19	peptide	peptide	NN
cord-001835-0s7ok4uw	264	20	,	,	,
cord-001835-0s7ok4uw	264	21	PSM	PSM	NNP
cord-001835-0s7ok4uw	264	22	b2	b2	NN
cord-001835-0s7ok4uw	264	23	was	be	VBD
cord-001835-0s7ok4uw	264	24	obtained	obtain	VBN
cord-001835-0s7ok4uw	264	25	.	.	.
cord-001835-0s7ok4uw	265	1	As	as	IN
cord-001835-0s7ok4uw	265	2	previously	previously	RB
cord-001835-0s7ok4uw	265	3	reported	report	VBN
cord-001835-0s7ok4uw	265	4	,	,	,
cord-001835-0s7ok4uw	265	5	the	the	DT
cord-001835-0s7ok4uw	265	6	PSMs	psm	NNS
cord-001835-0s7ok4uw	265	7	were	be	VBD
cord-001835-0s7ok4uw	265	8	found	find	VBN
cord-001835-0s7ok4uw	265	9	to	to	TO
cord-001835-0s7ok4uw	265	10	be	be	VB
cord-001835-0s7ok4uw	265	11	alpha	alpha	NN
cord-001835-0s7ok4uw	265	12	-	-	JJ
cord-001835-0s7ok4uw	265	13	helical	helical	JJ
cord-001835-0s7ok4uw	265	14	in	in	IN
cord-001835-0s7ok4uw	265	15	structure	structure	NN
cord-001835-0s7ok4uw	265	16	inducing	induce	VBG
cord-001835-0s7ok4uw	265	17	solvents	solvent	NNS
cord-001835-0s7ok4uw	265	18	.	.	.
cord-001835-0s7ok4uw	266	1	5	5	LS
cord-001835-0s7ok4uw	267	1	A	a	DT
cord-001835-0s7ok4uw	267	2	series	series	NN
cord-001835-0s7ok4uw	267	3	of	of	IN
cord-001835-0s7ok4uw	267	4	2	2	CD
cord-001835-0s7ok4uw	267	5	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	267	6	(	(	-LRB-
cord-001835-0s7ok4uw	267	7	2D	2D	NNP
cord-001835-0s7ok4uw	267	8	)	)	-RRB-
cord-001835-0s7ok4uw	267	9	NMR	NMR	NNP
cord-001835-0s7ok4uw	267	10	experiments	experiment	NNS
cord-001835-0s7ok4uw	267	11	were	be	VBD
cord-001835-0s7ok4uw	267	12	ran	run	VBN
cord-001835-0s7ok4uw	267	13	to	to	TO
cord-001835-0s7ok4uw	267	14	determine	determine	VB
cord-001835-0s7ok4uw	267	15	chemical	chemical	JJ
cord-001835-0s7ok4uw	267	16	shift	shift	NN
cord-001835-0s7ok4uw	267	17	assignments	assignment	NNS
cord-001835-0s7ok4uw	267	18	and	and	CC
cord-001835-0s7ok4uw	267	19	to	to	TO
cord-001835-0s7ok4uw	267	20	obtain	obtain	VB
cord-001835-0s7ok4uw	267	21	NOE	NOE	NNP
cord-001835-0s7ok4uw	267	22	data	datum	NNS
cord-001835-0s7ok4uw	267	23	.	.	.
cord-001835-0s7ok4uw	268	1	Importing	import	VBG
cord-001835-0s7ok4uw	268	2	the	the	DT
cord-001835-0s7ok4uw	268	3	chemical	chemical	JJ
cord-001835-0s7ok4uw	268	4	shift	shift	NN
cord-001835-0s7ok4uw	268	5	assignments	assignment	NNS
cord-001835-0s7ok4uw	268	6	and	and	CC
cord-001835-0s7ok4uw	268	7	NOE	NOE	NNP
cord-001835-0s7ok4uw	268	8	data	datum	NNS
cord-001835-0s7ok4uw	268	9	into	into	IN
cord-001835-0s7ok4uw	268	10	the	the	DT
cord-001835-0s7ok4uw	268	11	structure	structure	NN
cord-001835-0s7ok4uw	268	12	calculating	calculate	VBG
cord-001835-0s7ok4uw	268	13	software	software	NN
cord-001835-0s7ok4uw	268	14	,	,	,
cord-001835-0s7ok4uw	268	15	CYANA	CYANA	NNP
cord-001835-0s7ok4uw	268	16	,	,	,
cord-001835-0s7ok4uw	268	17	we	-PRON-	PRP
cord-001835-0s7ok4uw	268	18	were	be	VBD
cord-001835-0s7ok4uw	268	19	able	able	JJ
cord-001835-0s7ok4uw	268	20	to	to	TO
cord-001835-0s7ok4uw	268	21	elucidate	elucidate	VB
cord-001835-0s7ok4uw	268	22	the	the	DT
cord-001835-0s7ok4uw	268	23	solution	solution	NN
cord-001835-0s7ok4uw	268	24	structure	structure	NN
cord-001835-0s7ok4uw	268	25	of	of	IN
cord-001835-0s7ok4uw	268	26	PSM	PSM	NNP
cord-001835-0s7ok4uw	268	27	a1	a1	NNP
cord-001835-0s7ok4uw	268	28	and	and	CC
cord-001835-0s7ok4uw	268	29	PSM	PSM	NNP
cord-001835-0s7ok4uw	268	30	a3	a3	NNP
cord-001835-0s7ok4uw	268	31	and	and	CC
cord-001835-0s7ok4uw	268	32	we	-PRON-	PRP
cord-001835-0s7ok4uw	268	33	are	be	VBP
cord-001835-0s7ok4uw	268	34	currently	currently	RB
cord-001835-0s7ok4uw	268	35	working	work	VBG
cord-001835-0s7ok4uw	268	36	towards	towards	IN
cord-001835-0s7ok4uw	268	37	the	the	DT
cord-001835-0s7ok4uw	268	38	elucidation	elucidation	NN
cord-001835-0s7ok4uw	268	39	of	of	IN
cord-001835-0s7ok4uw	268	40	PSM	PSM	NNP
cord-001835-0s7ok4uw	268	41	b2	b2	NN
cord-001835-0s7ok4uw	268	42	.	.	.
cord-001835-0s7ok4uw	269	1	The	the	DT
cord-001835-0s7ok4uw	269	2	synthesis	synthesis	NN
cord-001835-0s7ok4uw	269	3	,	,	,
cord-001835-0s7ok4uw	269	4	isolation	isolation	NN
cord-001835-0s7ok4uw	269	5	,	,	,
cord-001835-0s7ok4uw	269	6	characterization	characterization	NN
cord-001835-0s7ok4uw	269	7	and	and	CC
cord-001835-0s7ok4uw	269	8	solution	solution	NN
cord-001835-0s7ok4uw	269	9	structures	structure	NNS
cord-001835-0s7ok4uw	269	10	of	of	IN
cord-001835-0s7ok4uw	269	11	the	the	DT
cord-001835-0s7ok4uw	269	12	aforementioned	aforementioned	JJ
cord-001835-0s7ok4uw	269	13	PSMs	psm	NNS
cord-001835-0s7ok4uw	269	14	will	will	MD
cord-001835-0s7ok4uw	269	15	be	be	VB
cord-001835-0s7ok4uw	269	16	discussed	discuss	VBN
cord-001835-0s7ok4uw	269	17	here	here	RB
cord-001835-0s7ok4uw	269	18	.	.	.
cord-001835-0s7ok4uw	270	1	1	1	CD
cord-001835-0s7ok4uw	270	2	Transition	transition	NN
cord-001835-0s7ok4uw	270	3	metals	metal	NNS
cord-001835-0s7ok4uw	270	4	are	be	VBP
cord-001835-0s7ok4uw	270	5	critical	critical	JJ
cord-001835-0s7ok4uw	270	6	for	for	IN
cord-001835-0s7ok4uw	270	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	270	8	function	function	NN
cord-001835-0s7ok4uw	270	9	and	and	CC
cord-001835-0s7ok4uw	270	10	protein	protein	NN
cord-001835-0s7ok4uw	270	11	folding	folding	NN
cord-001835-0s7ok4uw	270	12	,	,	,
cord-001835-0s7ok4uw	270	13	but	but	CC
cord-001835-0s7ok4uw	270	14	their	-PRON-	PRP$
cord-001835-0s7ok4uw	270	15	excess	excess	NN
cord-001835-0s7ok4uw	270	16	can	can	MD
cord-001835-0s7ok4uw	270	17	mediate	mediate	VB
cord-001835-0s7ok4uw	270	18	neurotoxic	neurotoxic	JJ
cord-001835-0s7ok4uw	270	19	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	270	20	processes	process	NNS
cord-001835-0s7ok4uw	270	21	[	[	-LRB-
cord-001835-0s7ok4uw	270	22	1	1	CD
cord-001835-0s7ok4uw	270	23	]	]	-RRB-
cord-001835-0s7ok4uw	270	24	.	.	.
cord-001835-0s7ok4uw	271	1	As	as	IN
cord-001835-0s7ok4uw	271	2	,	,	,
cord-001835-0s7ok4uw	271	3	energy	energy	NN
cord-001835-0s7ok4uw	271	4	production	production	NN
cord-001835-0s7ok4uw	271	5	involves	involve	VBZ
cord-001835-0s7ok4uw	271	6	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	271	7	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	271	8	,	,	,
cord-001835-0s7ok4uw	271	9	a	a	DT
cord-001835-0s7ok4uw	271	10	process	process	NN
cord-001835-0s7ok4uw	271	11	requiring	require	VBG
cord-001835-0s7ok4uw	271	12	a	a	DT
cord-001835-0s7ok4uw	271	13	continuous	continuous	JJ
cord-001835-0s7ok4uw	271	14	flow	flow	NN
cord-001835-0s7ok4uw	271	15	of	of	IN
cord-001835-0s7ok4uw	271	16	electrons	electron	NNS
cord-001835-0s7ok4uw	271	17	,	,	,
cord-001835-0s7ok4uw	271	18	mitochondria	mitochondrion	NNS
cord-001835-0s7ok4uw	271	19	are	be	VBP
cord-001835-0s7ok4uw	271	20	particularly	particularly	RB
cord-001835-0s7ok4uw	271	21	vulnerable	vulnerable	JJ
cord-001835-0s7ok4uw	271	22	to	to	IN
cord-001835-0s7ok4uw	271	23	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	271	24	damage	damage	NN
cord-001835-0s7ok4uw	271	25	[	[	-LRB-
cord-001835-0s7ok4uw	271	26	2	2	CD
cord-001835-0s7ok4uw	271	27	]	]	-RRB-
cord-001835-0s7ok4uw	271	28	.	.	.
cord-001835-0s7ok4uw	272	1	As	as	IN
cord-001835-0s7ok4uw	272	2	such	such	JJ
cord-001835-0s7ok4uw	272	3	,	,	,
cord-001835-0s7ok4uw	272	4	mitochondria	mitochondrion	NNS
cord-001835-0s7ok4uw	272	5	are	be	VBP
cord-001835-0s7ok4uw	272	6	the	the	DT
cord-001835-0s7ok4uw	272	7	major	major	JJ
cord-001835-0s7ok4uw	272	8	sites	site	NNS
cord-001835-0s7ok4uw	272	9	of	of	IN
cord-001835-0s7ok4uw	272	10	Reactive	Reactive	NNP
cord-001835-0s7ok4uw	272	11	Oxygen	Oxygen	NNP
cord-001835-0s7ok4uw	272	12	Species	Species	NNP
cord-001835-0s7ok4uw	272	13	(	(	-LRB-
cord-001835-0s7ok4uw	272	14	ROS	ROS	NNP
cord-001835-0s7ok4uw	272	15	)	)	-RRB-
cord-001835-0s7ok4uw	272	16	generation	generation	NN
cord-001835-0s7ok4uw	272	17	,	,	,
cord-001835-0s7ok4uw	272	18	which	which	WDT
cord-001835-0s7ok4uw	272	19	are	be	VBP
cord-001835-0s7ok4uw	272	20	produced	produce	VBN
cord-001835-0s7ok4uw	272	21	as	as	IN
cord-001835-0s7ok4uw	272	22	byproducts	byproduct	NNS
cord-001835-0s7ok4uw	272	23	of	of	IN
cord-001835-0s7ok4uw	272	24	the	the	DT
cord-001835-0s7ok4uw	272	25	electron	electron	NN
cord-001835-0s7ok4uw	272	26	transport	transport	NN
cord-001835-0s7ok4uw	272	27	chain	chain	NN
cord-001835-0s7ok4uw	272	28	.	.	.
cord-001835-0s7ok4uw	273	1	Since	since	IN
cord-001835-0s7ok4uw	273	2	free	free	JJ
cord-001835-0s7ok4uw	273	3	iron	iron	NN
cord-001835-0s7ok4uw	273	4	and	and	CC
cord-001835-0s7ok4uw	273	5	certain	certain	JJ
cord-001835-0s7ok4uw	273	6	ROS	ROS	NNP
cord-001835-0s7ok4uw	273	7	can	can	MD
cord-001835-0s7ok4uw	273	8	engage	engage	VB
cord-001835-0s7ok4uw	273	9	into	into	IN
cord-001835-0s7ok4uw	273	10	potentially	potentially	RB
cord-001835-0s7ok4uw	273	11	deleterious	deleterious	JJ
cord-001835-0s7ok4uw	273	12	processes	process	NNS
cord-001835-0s7ok4uw	273	13	such	such	JJ
cord-001835-0s7ok4uw	273	14	as	as	IN
cord-001835-0s7ok4uw	273	15	Fenton	Fenton	NNP
cord-001835-0s7ok4uw	273	16	reaction	reaction	NN
cord-001835-0s7ok4uw	273	17	,	,	,
cord-001835-0s7ok4uw	273	18	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	273	19	iron	iron	NN
cord-001835-0s7ok4uw	273	20	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	273	21	must	must	MD
cord-001835-0s7ok4uw	273	22	be	be	VB
cord-001835-0s7ok4uw	273	23	tightly	tightly	RB
cord-001835-0s7ok4uw	273	24	controlled	control	VBN
cord-001835-0s7ok4uw	273	25	,	,	,
cord-001835-0s7ok4uw	273	26	and	and	CC
cord-001835-0s7ok4uw	273	27	dysregulation	dysregulation	NN
cord-001835-0s7ok4uw	273	28	of	of	IN
cord-001835-0s7ok4uw	273	29	iron	iron	NN
cord-001835-0s7ok4uw	273	30	metabolism	metabolism	NN
cord-001835-0s7ok4uw	273	31	in	in	IN
cord-001835-0s7ok4uw	273	32	this	this	DT
cord-001835-0s7ok4uw	273	33	organelle	organelle	NN
cord-001835-0s7ok4uw	273	34	has	have	VBZ
cord-001835-0s7ok4uw	273	35	been	be	VBN
cord-001835-0s7ok4uw	273	36	associated	associate	VBN
cord-001835-0s7ok4uw	273	37	with	with	IN
cord-001835-0s7ok4uw	273	38	various	various	JJ
cord-001835-0s7ok4uw	273	39	diseases	disease	NNS
cord-001835-0s7ok4uw	273	40	,	,	,
cord-001835-0s7ok4uw	273	41	including	include	VBG
cord-001835-0s7ok4uw	273	42	Friedichs	friedichs	JJ
cord-001835-0s7ok4uw	273	43	ataxia	ataxia	NN
cord-001835-0s7ok4uw	273	44	(	(	-LRB-
cord-001835-0s7ok4uw	273	45	FA	FA	NNP
cord-001835-0s7ok4uw	273	46	)	)	-RRB-
cord-001835-0s7ok4uw	273	47	,	,	,
cord-001835-0s7ok4uw	273	48	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	273	49	's	's	POS
cord-001835-0s7ok4uw	273	50	,	,	,
cord-001835-0s7ok4uw	273	51	and	and	CC
cord-001835-0s7ok4uw	273	52	other	other	JJ
cord-001835-0s7ok4uw	273	53	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	273	54	disorders	disorder	NNS
cord-001835-0s7ok4uw	273	55	[	[	-LRB-
cord-001835-0s7ok4uw	273	56	3	3	CD
cord-001835-0s7ok4uw	273	57	]	]	-RRB-
cord-001835-0s7ok4uw	273	58	.	.	.
cord-001835-0s7ok4uw	274	1	Engineering	engineer	VBG
cord-001835-0s7ok4uw	274	2	an	an	DT
cord-001835-0s7ok4uw	274	3	efficient	efficient	JJ
cord-001835-0s7ok4uw	274	4	mitochondriatargeting	mitochondriatargeting	NN
cord-001835-0s7ok4uw	274	5	,	,	,
cord-001835-0s7ok4uw	274	6	cell	cell	NN
cord-001835-0s7ok4uw	274	7	-	-	HYPH
cord-001835-0s7ok4uw	274	8	permeable	permeable	JJ
cord-001835-0s7ok4uw	274	9	vector	vector	NN
cord-001835-0s7ok4uw	274	10	is	be	VBZ
cord-001835-0s7ok4uw	274	11	a	a	DT
cord-001835-0s7ok4uw	274	12	challenge	challenge	NN
cord-001835-0s7ok4uw	274	13	due	due	IN
cord-001835-0s7ok4uw	274	14	to	to	IN
cord-001835-0s7ok4uw	274	15	the	the	DT
cord-001835-0s7ok4uw	274	16	fact	fact	NN
cord-001835-0s7ok4uw	274	17	that	that	IN
cord-001835-0s7ok4uw	274	18	mitochondrion	mitochondrion	NN
cord-001835-0s7ok4uw	274	19	is	be	VBZ
cord-001835-0s7ok4uw	274	20	impermeable	impermeable	JJ
cord-001835-0s7ok4uw	274	21	to	to	IN
cord-001835-0s7ok4uw	274	22	a	a	DT
cord-001835-0s7ok4uw	274	23	wide	wide	JJ
cord-001835-0s7ok4uw	274	24	range	range	NN
cord-001835-0s7ok4uw	274	25	of	of	IN
cord-001835-0s7ok4uw	274	26	molecules	molecule	NNS
cord-001835-0s7ok4uw	274	27	.	.	.
cord-001835-0s7ok4uw	275	1	The	the	DT
cord-001835-0s7ok4uw	275	2	development	development	NN
cord-001835-0s7ok4uw	275	3	of	of	IN
cord-001835-0s7ok4uw	275	4	delivery	delivery	NN
cord-001835-0s7ok4uw	275	5	vectors	vector	NNS
cord-001835-0s7ok4uw	275	6	has	have	VBZ
cord-001835-0s7ok4uw	275	7	been	be	VBN
cord-001835-0s7ok4uw	275	8	made	make	VBN
cord-001835-0s7ok4uw	275	9	possible	possible	JJ
cord-001835-0s7ok4uw	275	10	by	by	IN
cord-001835-0s7ok4uw	275	11	a	a	DT
cord-001835-0s7ok4uw	275	12	greater	great	JJR
cord-001835-0s7ok4uw	275	13	understanding	understanding	NN
cord-001835-0s7ok4uw	275	14	of	of	IN
cord-001835-0s7ok4uw	275	15	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	275	16	structure	structure	NN
cord-001835-0s7ok4uw	275	17	and	and	CC
cord-001835-0s7ok4uw	275	18	chemical	chemical	NN
cord-001835-0s7ok4uw	275	19	features	feature	NNS
cord-001835-0s7ok4uw	275	20	of	of	IN
cord-001835-0s7ok4uw	275	21	molecules	molecule	NNS
cord-001835-0s7ok4uw	275	22	that	that	WDT
cord-001835-0s7ok4uw	275	23	selectively	selectively	RB
cord-001835-0s7ok4uw	275	24	localize	localize	VBP
cord-001835-0s7ok4uw	275	25	within	within	IN
cord-001835-0s7ok4uw	275	26	this	this	DT
cord-001835-0s7ok4uw	275	27	organelle	organelle	NN
cord-001835-0s7ok4uw	275	28	.	.	.
cord-001835-0s7ok4uw	276	1	From	from	IN
cord-001835-0s7ok4uw	276	2	these	these	DT
cord-001835-0s7ok4uw	276	3	findings	finding	NNS
cord-001835-0s7ok4uw	276	4	,	,	,
cord-001835-0s7ok4uw	276	5	two	two	CD
cord-001835-0s7ok4uw	276	6	generalized	generalized	JJ
cord-001835-0s7ok4uw	276	7	requirements	requirement	NNS
cord-001835-0s7ok4uw	276	8	for	for	IN
cord-001835-0s7ok4uw	276	9	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	276	10	localization	localization	NN
cord-001835-0s7ok4uw	276	11	are	be	VBP
cord-001835-0s7ok4uw	276	12	delocalized	delocalize	VBN
cord-001835-0s7ok4uw	276	13	positive	positive	JJ
cord-001835-0s7ok4uw	276	14	charge	charge	NN
cord-001835-0s7ok4uw	276	15	and	and	CC
cord-001835-0s7ok4uw	276	16	lipophilicity	lipophilicity	NN
cord-001835-0s7ok4uw	276	17	[	[	-LRB-
cord-001835-0s7ok4uw	276	18	4	4	CD
cord-001835-0s7ok4uw	276	19	,	,	,
cord-001835-0s7ok4uw	276	20	5	5	CD
cord-001835-0s7ok4uw	276	21	]	]	-RRB-
cord-001835-0s7ok4uw	276	22	.	.	.
cord-001835-0s7ok4uw	277	1	Targeting	target	VBG
cord-001835-0s7ok4uw	277	2	iron	iron	NN
cord-001835-0s7ok4uw	277	3	in	in	IN
cord-001835-0s7ok4uw	277	4	this	this	DT
cord-001835-0s7ok4uw	277	5	organelle	organelle	NN
cord-001835-0s7ok4uw	277	6	is	be	VBZ
cord-001835-0s7ok4uw	277	7	proposed	propose	VBN
cord-001835-0s7ok4uw	277	8	as	as	IN
cord-001835-0s7ok4uw	277	9	a	a	DT
cord-001835-0s7ok4uw	277	10	means	means	NN
cord-001835-0s7ok4uw	277	11	to	to	TO
cord-001835-0s7ok4uw	277	12	ameliorate	ameliorate	VB
cord-001835-0s7ok4uw	277	13	FA	FA	NNP
cord-001835-0s7ok4uw	277	14	symptoms	symptom	NNS
cord-001835-0s7ok4uw	277	15	.	.	.
cord-001835-0s7ok4uw	278	1	Desferrioxamine	Desferrioxamine	NNP
cord-001835-0s7ok4uw	278	2	(	(	-LRB-
cord-001835-0s7ok4uw	278	3	DFO	DFO	NNP
cord-001835-0s7ok4uw	278	4	)	)	-RRB-
cord-001835-0s7ok4uw	278	5	is	be	VBZ
cord-001835-0s7ok4uw	278	6	a	a	DT
cord-001835-0s7ok4uw	278	7	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	278	8	siderophore	siderophore	NN
cord-001835-0s7ok4uw	278	9	with	with	IN
cord-001835-0s7ok4uw	278	10	high	high	JJ
cord-001835-0s7ok4uw	278	11	affinity	affinity	NN
cord-001835-0s7ok4uw	278	12	for	for	IN
cord-001835-0s7ok4uw	278	13	iron	iron	NN
cord-001835-0s7ok4uw	278	14	,	,	,
cord-001835-0s7ok4uw	278	15	but	but	CC
cord-001835-0s7ok4uw	278	16	low	low	JJ
cord-001835-0s7ok4uw	278	17	cell	cell	NN
cord-001835-0s7ok4uw	278	18	penetration	penetration	NN
cord-001835-0s7ok4uw	278	19	.	.	.
cord-001835-0s7ok4uw	279	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	279	2	prepared	prepare	VBD
cord-001835-0s7ok4uw	279	3	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	279	4	of	of	IN
cord-001835-0s7ok4uw	279	5	DFO	DFO	NNP
cord-001835-0s7ok4uw	279	6	with	with	IN
cord-001835-0s7ok4uw	279	7	Mitochondria	Mitochondria	NNP
cord-001835-0s7ok4uw	279	8	Penetrating	Penetrating	NNP
cord-001835-0s7ok4uw	279	9	Peptides	peptide	NNS
cord-001835-0s7ok4uw	279	10	and	and	CC
cord-001835-0s7ok4uw	279	11	studied	study	VBD
cord-001835-0s7ok4uw	279	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	279	13	iron	iron	NN
cord-001835-0s7ok4uw	279	14	-	-	HYPH
cord-001835-0s7ok4uw	279	15	binding	bind	VBG
cord-001835-0s7ok4uw	279	16	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	279	17	in	in	IN
cord-001835-0s7ok4uw	279	18	vitro	vitro	FW
cord-001835-0s7ok4uw	279	19	.	.	.
cord-001835-0s7ok4uw	280	1	The	the	DT
cord-001835-0s7ok4uw	280	2	lipophilic	lipophilic	JJ
cord-001835-0s7ok4uw	280	3	and	and	CC
cord-001835-0s7ok4uw	280	4	charged	charge	VBN
cord-001835-0s7ok4uw	280	5	peptides	peptide	NNS
cord-001835-0s7ok4uw	281	1	TAT49	tat49	NN
cord-001835-0s7ok4uw	281	2	-	-	:
cord-001835-0s7ok4uw	281	3	57	57	CD
cord-001835-0s7ok4uw	282	1	(	(	-LRB-
cord-001835-0s7ok4uw	282	2	H	h	NN
cord-001835-0s7ok4uw	282	3	-	-	HYPH
cord-001835-0s7ok4uw	282	4	Arg	Arg	NNP
cord-001835-0s7ok4uw	282	5	-	-	HYPH
cord-001835-0s7ok4uw	282	6	Lys	Lys	NNP
cord-001835-0s7ok4uw	282	7	-	-	HYPH
cord-001835-0s7ok4uw	282	8	Lys	Lys	NNP
cord-001835-0s7ok4uw	282	9	-	-	HYPH
cord-001835-0s7ok4uw	282	10	Arg	arg	NN
cord-001835-0s7ok4uw	282	11	-	-	HYPH
cord-001835-0s7ok4uw	282	12	Arg	arg	NN
cord-001835-0s7ok4uw	282	13	-	-	HYPH
cord-001835-0s7ok4uw	282	14	Gln	Gln	NNP
cord-001835-0s7ok4uw	282	15	-	-	HYPH
cord-001835-0s7ok4uw	282	16	Arg	arg	NN
cord-001835-0s7ok4uw	282	17	-	-	HYPH
cord-001835-0s7ok4uw	282	18	Arg	arg	NN
cord-001835-0s7ok4uw	282	19	-	-	HYPH
cord-001835-0s7ok4uw	282	20	Arg	arg	NN
cord-001835-0s7ok4uw	282	21	-	-	HYPH
cord-001835-0s7ok4uw	282	22	OH	OH	NNP
cord-001835-0s7ok4uw	282	23	)	)	-RRB-
cord-001835-0s7ok4uw	282	24	[	[	-LRB-
cord-001835-0s7ok4uw	282	25	6	6	CD
cord-001835-0s7ok4uw	282	26	]	]	-RRB-
cord-001835-0s7ok4uw	282	27	,	,	.
cord-001835-0s7ok4uw	283	1	1A	1a	LS
cord-001835-0s7ok4uw	283	2	(	(	-LRB-
cord-001835-0s7ok4uw	283	3	H	H	NNP
cord-001835-0s7ok4uw	283	4	-	-	HYPH
cord-001835-0s7ok4uw	283	5	Cha	cha	NN
cord-001835-0s7ok4uw	283	6	-	-	HYPH
cord-001835-0s7ok4uw	283	7	Arg	arg	NN
cord-001835-0s7ok4uw	283	8	-	-	HYPH
cord-001835-0s7ok4uw	283	9	Cha	Cha	NNP
cord-001835-0s7ok4uw	283	10	-	-	HYPH
cord-001835-0s7ok4uw	283	11	Lys	Lys	NNP
cord-001835-0s7ok4uw	283	12	-	-	HYPH
cord-001835-0s7ok4uw	283	13	Cha	Cha	NNP
cord-001835-0s7ok4uw	283	14	-	-	HYPH
cord-001835-0s7ok4uw	283	15	Arg	arg	NN
cord-001835-0s7ok4uw	283	16	-	-	HYPH
cord-001835-0s7ok4uw	283	17	Cha	Cha	NNP
cord-001835-0s7ok4uw	283	18	-	-	HYPH
cord-001835-0s7ok4uw	283	19	Lys	Lys	NNP
cord-001835-0s7ok4uw	283	20	-	-	HYPH
cord-001835-0s7ok4uw	283	21	NH2	NH2	NNP
cord-001835-0s7ok4uw	283	22	)	)	-RRB-
cord-001835-0s7ok4uw	283	23	[	[	-LRB-
cord-001835-0s7ok4uw	283	24	6	6	CD
cord-001835-0s7ok4uw	283	25	]	]	-RRB-
cord-001835-0s7ok4uw	283	26	,	,	,
cord-001835-0s7ok4uw	283	27	SS-02	SS-02	NNP
cord-001835-0s7ok4uw	283	28	(	(	-LRB-
cord-001835-0s7ok4uw	283	29	H	H	NNP
cord-001835-0s7ok4uw	283	30	-	-	HYPH
cord-001835-0s7ok4uw	283	31	Dmt	Dmt	NNP
cord-001835-0s7ok4uw	283	32	-	-	HYPH
cord-001835-0s7ok4uw	283	33	Arg	arg	NN
cord-001835-0s7ok4uw	283	34	-	-	HYPH
cord-001835-0s7ok4uw	283	35	Phe	Phe	NNP
cord-001835-0s7ok4uw	283	36	-	-	HYPH
cord-001835-0s7ok4uw	283	37	Lys	Lys	NNP
cord-001835-0s7ok4uw	283	38	-	-	HYPH
cord-001835-0s7ok4uw	283	39	NH2	NH2	NNP
cord-001835-0s7ok4uw	283	40	)	)	-RRB-
cord-001835-0s7ok4uw	283	41	[	[	-LRB-
cord-001835-0s7ok4uw	283	42	7	7	CD
cord-001835-0s7ok4uw	283	43	]	]	-RRB-
cord-001835-0s7ok4uw	283	44	and	and	CC
cord-001835-0s7ok4uw	283	45	SS-20	SS-20	NNP
cord-001835-0s7ok4uw	283	46	(	(	-LRB-
cord-001835-0s7ok4uw	283	47	H	H	NNP
cord-001835-0s7ok4uw	283	48	-	-	HYPH
cord-001835-0s7ok4uw	283	49	Phe	phe	NN
cord-001835-0s7ok4uw	283	50	-	-	HYPH
cord-001835-0s7ok4uw	283	51	Arg	arg	NN
cord-001835-0s7ok4uw	283	52	-	-	HYPH
cord-001835-0s7ok4uw	283	53	Phe	Phe	NNP
cord-001835-0s7ok4uw	283	54	-	-	HYPH
cord-001835-0s7ok4uw	283	55	Lys	Lys	NNP
cord-001835-0s7ok4uw	283	56	-	-	HYPH
cord-001835-0s7ok4uw	283	57	NH2	NH2	NNP
cord-001835-0s7ok4uw	283	58	)	)	-RRB-
cord-001835-0s7ok4uw	283	59	[	[	-LRB-
cord-001835-0s7ok4uw	283	60	7	7	CD
cord-001835-0s7ok4uw	283	61	]	]	-RRB-
cord-001835-0s7ok4uw	283	62	,	,	,
cord-001835-0s7ok4uw	283	63	are	be	VBP
cord-001835-0s7ok4uw	283	64	known	know	VBN
cord-001835-0s7ok4uw	283	65	to	to	TO
cord-001835-0s7ok4uw	283	66	permeate	permeate	VB
cord-001835-0s7ok4uw	283	67	cytosolic	cytosolic	JJ
cord-001835-0s7ok4uw	283	68	and	and	CC
cord-001835-0s7ok4uw	283	69	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	283	70	membranes	membrane	NNS
cord-001835-0s7ok4uw	283	71	.	.	.
cord-001835-0s7ok4uw	284	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	284	2	were	be	VBD
cord-001835-0s7ok4uw	284	3	prepared	prepare	VBN
cord-001835-0s7ok4uw	284	4	and	and	CC
cord-001835-0s7ok4uw	284	5	conjugated	conjugate	VBN
cord-001835-0s7ok4uw	284	6	to	to	IN
cord-001835-0s7ok4uw	284	7	DFO	DFO	NNP
cord-001835-0s7ok4uw	284	8	in	in	IN
cord-001835-0s7ok4uw	284	9	solid	solid	JJ
cord-001835-0s7ok4uw	284	10	-	-	HYPH
cord-001835-0s7ok4uw	284	11	phase	phase	NN
cord-001835-0s7ok4uw	284	12	[	[	-LRB-
cord-001835-0s7ok4uw	284	13	8	8	CD
cord-001835-0s7ok4uw	284	14	]	]	-RRB-
cord-001835-0s7ok4uw	284	15	,	,	,
cord-001835-0s7ok4uw	284	16	an	an	DT
cord-001835-0s7ok4uw	284	17	alternative	alternative	JJ
cord-001835-0s7ok4uw	284	18	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	284	19	route	route	NN
cord-001835-0s7ok4uw	284	20	.	.	.
cord-001835-0s7ok4uw	285	1	Once	once	RB
cord-001835-0s7ok4uw	285	2	detached	detached	JJ
cord-001835-0s7ok4uw	285	3	from	from	IN
cord-001835-0s7ok4uw	285	4	the	the	DT
cord-001835-0s7ok4uw	285	5	resin	resin	NN
cord-001835-0s7ok4uw	285	6	,	,	,
cord-001835-0s7ok4uw	285	7	fully	fully	RB
cord-001835-0s7ok4uw	285	8	deprotected	deprotecte	VBN
cord-001835-0s7ok4uw	285	9	,	,	,
cord-001835-0s7ok4uw	285	10	purified	purify	VBN
cord-001835-0s7ok4uw	285	11	and	and	CC
cord-001835-0s7ok4uw	285	12	characterized	characterize	VBN
cord-001835-0s7ok4uw	285	13	by	by	IN
cord-001835-0s7ok4uw	285	14	means	mean	NNS
cord-001835-0s7ok4uw	285	15	of	of	IN
cord-001835-0s7ok4uw	285	16	LC	LC	NNP
cord-001835-0s7ok4uw	285	17	/	/	SYM
cord-001835-0s7ok4uw	285	18	MS	MS	NNP
cord-001835-0s7ok4uw	285	19	and	and	CC
cord-001835-0s7ok4uw	285	20	aminoacid	aminoacid	NNP
cord-001835-0s7ok4uw	285	21	analysis	analysis	NN
cord-001835-0s7ok4uw	285	22	,	,	,
cord-001835-0s7ok4uw	285	23	it	-PRON-	PRP
cord-001835-0s7ok4uw	285	24	was	be	VBD
cord-001835-0s7ok4uw	285	25	observed	observe	VBN
cord-001835-0s7ok4uw	285	26	that	that	IN
cord-001835-0s7ok4uw	285	27	the	the	DT
cord-001835-0s7ok4uw	285	28	DFO	DFO	NNP
cord-001835-0s7ok4uw	285	29	-	-	HYPH
cord-001835-0s7ok4uw	285	30	conjugated	conjugate	VBN
cord-001835-0s7ok4uw	285	31	peptides	peptide	NNS
cord-001835-0s7ok4uw	285	32	displayed	display	VBD
cord-001835-0s7ok4uw	285	33	iron	iron	NN
cord-001835-0s7ok4uw	285	34	-	-	HYPH
cord-001835-0s7ok4uw	285	35	binding	bind	VBG
cord-001835-0s7ok4uw	285	36	abilities	ability	NNS
cord-001835-0s7ok4uw	285	37	identical	identical	JJ
cord-001835-0s7ok4uw	285	38	to	to	IN
cord-001835-0s7ok4uw	285	39	the	the	DT
cord-001835-0s7ok4uw	285	40	free	free	JJ
cord-001835-0s7ok4uw	285	41	chelator	chelator	NN
cord-001835-0s7ok4uw	285	42	DFO	DFO	NNP
cord-001835-0s7ok4uw	285	43	.	.	.
cord-001835-0s7ok4uw	286	1	DFO	DFO	NNP
cord-001835-0s7ok4uw	286	2	-	-	HYPH
cord-001835-0s7ok4uw	286	3	conjugated	conjugate	VBN
cord-001835-0s7ok4uw	286	4	peptides	peptide	NNS
cord-001835-0s7ok4uw	286	5	were	be	VBD
cord-001835-0s7ok4uw	286	6	also	also	RB
cord-001835-0s7ok4uw	286	7	able	able	JJ
cord-001835-0s7ok4uw	286	8	to	to	TO
cord-001835-0s7ok4uw	286	9	quench	quench	VB
cord-001835-0s7ok4uw	286	10	the	the	DT
cord-001835-0s7ok4uw	286	11	iron	iron	NN
cord-001835-0s7ok4uw	286	12	-	-	HYPH
cord-001835-0s7ok4uw	286	13	catalysed	catalyse	VBN
cord-001835-0s7ok4uw	286	14	oxidation	oxidation	NN
cord-001835-0s7ok4uw	286	15	of	of	IN
cord-001835-0s7ok4uw	286	16	ascorbate	ascorbate	NN
cord-001835-0s7ok4uw	286	17	(	(	-LRB-
cord-001835-0s7ok4uw	286	18	a	a	DT
cord-001835-0s7ok4uw	286	19	model	model	NN
cord-001835-0s7ok4uw	286	20	of	of	IN
cord-001835-0s7ok4uw	286	21	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	286	22	stress	stress	NN
cord-001835-0s7ok4uw	286	23	in	in	IN
cord-001835-0s7ok4uw	286	24	plasma	plasma	NN
cord-001835-0s7ok4uw	286	25	of	of	IN
cord-001835-0s7ok4uw	286	26	iron	iron	NN
cord-001835-0s7ok4uw	286	27	-	-	HYPH
cord-001835-0s7ok4uw	286	28	overloaded	overloaded	JJ
cord-001835-0s7ok4uw	286	29	patients	patient	NNS
cord-001835-0s7ok4uw	286	30	)	)	-RRB-
cord-001835-0s7ok4uw	286	31	,	,	,
cord-001835-0s7ok4uw	286	32	as	as	IN
cord-001835-0s7ok4uw	286	33	probed	probe	VBN
cord-001835-0s7ok4uw	286	34	by	by	IN
cord-001835-0s7ok4uw	286	35	a	a	DT
cord-001835-0s7ok4uw	286	36	high	high	JJ
cord-001835-0s7ok4uw	286	37	throughput	throughput	NN
cord-001835-0s7ok4uw	286	38	fluorimetric	fluorimetric	NN
cord-001835-0s7ok4uw	286	39	method	method	NN
cord-001835-0s7ok4uw	286	40	[	[	-LRB-
cord-001835-0s7ok4uw	286	41	9	9	CD
cord-001835-0s7ok4uw	286	42	,	,	,
cord-001835-0s7ok4uw	286	43	10	10	CD
cord-001835-0s7ok4uw	286	44	]	]	-RRB-
cord-001835-0s7ok4uw	286	45	.	.	.
cord-001835-0s7ok4uw	287	1	These	these	DT
cord-001835-0s7ok4uw	287	2	results	result	NNS
cord-001835-0s7ok4uw	287	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	287	4	that	that	IN
cord-001835-0s7ok4uw	287	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	287	6	synthesis	synthesis	NN
cord-001835-0s7ok4uw	287	7	and	and	CC
cord-001835-0s7ok4uw	287	8	conjugation	conjugation	NN
cord-001835-0s7ok4uw	287	9	strategy	strategy	NN
cord-001835-0s7ok4uw	287	10	were	be	VBD
cord-001835-0s7ok4uw	287	11	successful	successful	JJ
cord-001835-0s7ok4uw	287	12	in	in	IN
cord-001835-0s7ok4uw	287	13	preserving	preserve	VBG
cord-001835-0s7ok4uw	287	14	the	the	DT
cord-001835-0s7ok4uw	287	15	iron	iron	NN
cord-001835-0s7ok4uw	287	16	-	-	HYPH
cord-001835-0s7ok4uw	287	17	binding	bind	VBG
cord-001835-0s7ok4uw	287	18	moiety	moiety	NN
cord-001835-0s7ok4uw	287	19	and	and	CC
cord-001835-0s7ok4uw	287	20	the	the	DT
cord-001835-0s7ok4uw	287	21	antioxidant	antioxidant	JJ
cord-001835-0s7ok4uw	287	22	ability	ability	NN
cord-001835-0s7ok4uw	287	23	of	of	IN
cord-001835-0s7ok4uw	287	24	the	the	DT
cord-001835-0s7ok4uw	287	25	free	free	JJ
cord-001835-0s7ok4uw	287	26	chelator	chelator	NN
cord-001835-0s7ok4uw	287	27	DFO	DFO	NNP
cord-001835-0s7ok4uw	287	28	.	.	.
cord-001835-0s7ok4uw	288	1	The	the	DT
cord-001835-0s7ok4uw	288	2	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	288	3	activity	activity	NN
cord-001835-0s7ok4uw	288	4	and	and	CC
cord-001835-0s7ok4uw	288	5	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	288	6	status	status	NN
cord-001835-0s7ok4uw	288	7	of	of	IN
cord-001835-0s7ok4uw	288	8	the	the	DT
cord-001835-0s7ok4uw	288	9	human	human	JJ
cord-001835-0s7ok4uw	288	10	HtrA3	HtrA3	NNP
cord-001835-0s7ok4uw	288	11	protease	protease	NN
cord-001835-0s7ok4uw	288	12	functioning	function	VBG
cord-001835-0s7ok4uw	288	13	as	as	IN
cord-001835-0s7ok4uw	288	14	a	a	DT
cord-001835-0s7ok4uw	288	15	tumor	tumor	NN
cord-001835-0s7ok4uw	288	16	suppressor	suppressor	NN
cord-001835-0s7ok4uw	288	17	of	of	IN
cord-001835-0s7ok4uw	288	18	an	an	DT
cord-001835-0s7ok4uw	288	19	N	n	CD
cord-001835-0s7ok4uw	288	20	-	-	HYPH
cord-001835-0s7ok4uw	288	21	terminal	terminal	NN
cord-001835-0s7ok4uw	288	22	domain	domain	NN
cord-001835-0s7ok4uw	288	23	not	not	RB
cord-001835-0s7ok4uw	288	24	required	require	VBN
cord-001835-0s7ok4uw	288	25	for	for	IN
cord-001835-0s7ok4uw	288	26	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	288	27	activity	activity	NN
cord-001835-0s7ok4uw	288	28	,	,	,
cord-001835-0s7ok4uw	288	29	a	a	DT
cord-001835-0s7ok4uw	288	30	central	central	JJ
cord-001835-0s7ok4uw	288	31	serine	serine	NN
cord-001835-0s7ok4uw	288	32	protease	protease	NN
cord-001835-0s7ok4uw	288	33	domain	domain	NN
cord-001835-0s7ok4uw	288	34	and	and	CC
cord-001835-0s7ok4uw	288	35	a	a	DT
cord-001835-0s7ok4uw	288	36	Cterminal	Cterminal	NNP
cord-001835-0s7ok4uw	288	37	PDZ	PDZ	NNP
cord-001835-0s7ok4uw	288	38	domain	domain	NN
cord-001835-0s7ok4uw	288	39	.	.	.
cord-001835-0s7ok4uw	289	1	The	the	DT
cord-001835-0s7ok4uw	289	2	latter	latter	JJ
cord-001835-0s7ok4uw	289	3	serves	serve	VBZ
cord-001835-0s7ok4uw	289	4	as	as	IN
cord-001835-0s7ok4uw	289	5	a	a	DT
cord-001835-0s7ok4uw	289	6	substrate	substrate	NN
cord-001835-0s7ok4uw	289	7	or	or	CC
cord-001835-0s7ok4uw	289	8	regulator	regulator	NN
cord-001835-0s7ok4uw	289	9	binding	bind	VBG
cord-001835-0s7ok4uw	289	10	domain	domain	NN
cord-001835-0s7ok4uw	289	11	and	and	CC
cord-001835-0s7ok4uw	289	12	may	may	MD
cord-001835-0s7ok4uw	289	13	participate	participate	VB
cord-001835-0s7ok4uw	289	14	in	in	IN
cord-001835-0s7ok4uw	289	15	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	289	16	.	.	.
cord-001835-0s7ok4uw	290	1	HtrA3S	HtrA3S	NNP
cord-001835-0s7ok4uw	290	2	,	,	,
cord-001835-0s7ok4uw	290	3	its	-PRON-	PRP$
cord-001835-0s7ok4uw	290	4	short	short	JJ
cord-001835-0s7ok4uw	290	5	natural	natural	JJ
cord-001835-0s7ok4uw	290	6	isoform	isoform	NN
cord-001835-0s7ok4uw	290	7	,	,	,
cord-001835-0s7ok4uw	290	8	lacks	lack	VBZ
cord-001835-0s7ok4uw	290	9	the	the	DT
cord-001835-0s7ok4uw	290	10	PDZ	PDZ	NNP
cord-001835-0s7ok4uw	290	11	domain	domain	NN
cord-001835-0s7ok4uw	290	12	which	which	WDT
cord-001835-0s7ok4uw	290	13	is	be	VBZ
cord-001835-0s7ok4uw	290	14	substituted	substitute	VBN
cord-001835-0s7ok4uw	290	15	by	by	IN
cord-001835-0s7ok4uw	290	16	a	a	DT
cord-001835-0s7ok4uw	290	17	stretch	stretch	NN
cord-001835-0s7ok4uw	290	18	of	of	IN
cord-001835-0s7ok4uw	290	19	7	7	CD
cord-001835-0s7ok4uw	290	20	C	c	NN
cord-001835-0s7ok4uw	290	21	-	-	HYPH
cord-001835-0s7ok4uw	290	22	terminal	terminal	NN
cord-001835-0s7ok4uw	290	23	amino	amino	NN
cord-001835-0s7ok4uw	290	24	acid	acid	NN
cord-001835-0s7ok4uw	290	25	residues	residue	NNS
cord-001835-0s7ok4uw	290	26	,	,	,
cord-001835-0s7ok4uw	290	27	unique	unique	JJ
cord-001835-0s7ok4uw	290	28	for	for	IN
cord-001835-0s7ok4uw	290	29	this	this	DT
cord-001835-0s7ok4uw	290	30	isoform	isoform	NN
cord-001835-0s7ok4uw	290	31	.	.	.
cord-001835-0s7ok4uw	291	1	Down	down	IN
cord-001835-0s7ok4uw	291	2	-	-	HYPH
cord-001835-0s7ok4uw	291	3	regulation	regulation	NN
cord-001835-0s7ok4uw	291	4	of	of	IN
cord-001835-0s7ok4uw	291	5	HtrA3	HtrA3	NNP
cord-001835-0s7ok4uw	291	6	in	in	IN
cord-001835-0s7ok4uw	291	7	tumors	tumor	NNS
cord-001835-0s7ok4uw	291	8	,	,	,
cord-001835-0s7ok4uw	291	9	shown	show	VBN
cord-001835-0s7ok4uw	291	10	by	by	IN
cord-001835-0s7ok4uw	291	11	other	other	JJ
cord-001835-0s7ok4uw	291	12	groups	group	NNS
cord-001835-0s7ok4uw	291	13	and	and	CC
cord-001835-0s7ok4uw	291	14	us	-PRON-	PRP
cord-001835-0s7ok4uw	291	15	,	,	,
cord-001835-0s7ok4uw	291	16	suggests	suggest	VBZ
cord-001835-0s7ok4uw	291	17	HtrA3s	HtrA3s	NNP
cord-001835-0s7ok4uw	291	18	involvement	involvement	NN
cord-001835-0s7ok4uw	291	19	in	in	IN
cord-001835-0s7ok4uw	291	20	oncogenesis	oncogenesis	NNP
cord-001835-0s7ok4uw	291	21	[	[	-LRB-
cord-001835-0s7ok4uw	291	22	1	1	CD
cord-001835-0s7ok4uw	291	23	]	]	-RRB-
cord-001835-0s7ok4uw	291	24	.	.	.
cord-001835-0s7ok4uw	292	1	HtrA3	HtrA3	NNP
cord-001835-0s7ok4uw	292	2	acts	act	VBZ
cord-001835-0s7ok4uw	292	3	as	as	IN
cord-001835-0s7ok4uw	292	4	a	a	DT
cord-001835-0s7ok4uw	292	5	proapoptotic	proapoptotic	JJ
cord-001835-0s7ok4uw	292	6	protein	protein	NN
cord-001835-0s7ok4uw	292	7	and	and	CC
cord-001835-0s7ok4uw	292	8	is	be	VBZ
cord-001835-0s7ok4uw	292	9	suggested	suggest	VBN
cord-001835-0s7ok4uw	292	10	to	to	TO
cord-001835-0s7ok4uw	292	11	function	function	VB
cord-001835-0s7ok4uw	292	12	as	as	IN
cord-001835-0s7ok4uw	292	13	a	a	DT
cord-001835-0s7ok4uw	292	14	tumor	tumor	NN
cord-001835-0s7ok4uw	292	15	suppressor	suppressor	NN
cord-001835-0s7ok4uw	292	16	.	.	.
cord-001835-0s7ok4uw	293	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	293	2	promotes	promote	VBZ
cord-001835-0s7ok4uw	293	3	cytotoxicity	cytotoxicity	NN
cord-001835-0s7ok4uw	293	4	of	of	IN
cord-001835-0s7ok4uw	293	5	etoposide	etoposide	NN
cord-001835-0s7ok4uw	293	6	and	and	CC
cord-001835-0s7ok4uw	293	7	cisplatin	cisplatin	NN
cord-001835-0s7ok4uw	293	8	in	in	IN
cord-001835-0s7ok4uw	293	9	lung	lung	NN
cord-001835-0s7ok4uw	293	10	cancer	cancer	NN
cord-001835-0s7ok4uw	293	11	cell	cell	NN
cord-001835-0s7ok4uw	293	12	lines	line	NNS
cord-001835-0s7ok4uw	293	13	[	[	-LRB-
cord-001835-0s7ok4uw	293	14	2	2	CD
cord-001835-0s7ok4uw	293	15	,	,	,
cord-001835-0s7ok4uw	293	16	3	3	CD
cord-001835-0s7ok4uw	293	17	]	]	-RRB-
cord-001835-0s7ok4uw	293	18	.	.	.
cord-001835-0s7ok4uw	294	1	To	to	IN
cord-001835-0s7ok4uw	294	2	date	date	NN
cord-001835-0s7ok4uw	294	3	,	,	,
cord-001835-0s7ok4uw	294	4	HtrA3	HtrA3	NNP
cord-001835-0s7ok4uw	294	5	has	have	VBZ
cord-001835-0s7ok4uw	294	6	been	be	VBN
cord-001835-0s7ok4uw	294	7	poorly	poorly	RB
cord-001835-0s7ok4uw	294	8	characterized	characterize	VBN
cord-001835-0s7ok4uw	294	9	from	from	IN
cord-001835-0s7ok4uw	294	10	the	the	DT
cord-001835-0s7ok4uw	294	11	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	294	12	point	point	NN
cord-001835-0s7ok4uw	294	13	of	of	IN
cord-001835-0s7ok4uw	294	14	view	view	NN
cord-001835-0s7ok4uw	294	15	,	,	,
cord-001835-0s7ok4uw	294	16	mainly	mainly	RB
cord-001835-0s7ok4uw	294	17	due	due	IN
cord-001835-0s7ok4uw	294	18	to	to	IN
cord-001835-0s7ok4uw	294	19	the	the	DT
cord-001835-0s7ok4uw	294	20	fact	fact	NN
cord-001835-0s7ok4uw	294	21	that	that	IN
cord-001835-0s7ok4uw	294	22	it	-PRON-	PRP
cord-001835-0s7ok4uw	294	23	is	be	VBZ
cord-001835-0s7ok4uw	294	24	difficult	difficult	JJ
cord-001835-0s7ok4uw	294	25	to	to	TO
cord-001835-0s7ok4uw	294	26	purify	purify	VB
cord-001835-0s7ok4uw	294	27	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	294	28	HtrA3	HtrA3	NNP
cord-001835-0s7ok4uw	294	29	.	.	.
cord-001835-0s7ok4uw	295	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	295	2	were	be	VBD
cord-001835-0s7ok4uw	295	3	able	able	JJ
cord-001835-0s7ok4uw	295	4	to	to	TO
cord-001835-0s7ok4uw	295	5	express	express	VB
cord-001835-0s7ok4uw	295	6	in	in	IN
cord-001835-0s7ok4uw	295	7	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	295	8	system	system	NN
cord-001835-0s7ok4uw	295	9	and	and	CC
cord-001835-0s7ok4uw	295	10	purify	purify	VB
cord-001835-0s7ok4uw	295	11	HtrA3	HtrA3	NNP
cord-001835-0s7ok4uw	295	12	in	in	IN
cord-001835-0s7ok4uw	295	13	quantities	quantity	NNS
cord-001835-0s7ok4uw	295	14	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	295	15	to	to	TO
cord-001835-0s7ok4uw	295	16	perform	perform	VB
cord-001835-0s7ok4uw	295	17	structural	structural	JJ
cord-001835-0s7ok4uw	295	18	studies	study	NNS
cord-001835-0s7ok4uw	295	19	.	.	.
cord-001835-0s7ok4uw	296	1	The	the	DT
cord-001835-0s7ok4uw	296	2	aim	aim	NN
cord-001835-0s7ok4uw	296	3	of	of	IN
cord-001835-0s7ok4uw	296	4	this	this	DT
cord-001835-0s7ok4uw	296	5	study	study	NN
cord-001835-0s7ok4uw	296	6	was	be	VBD
cord-001835-0s7ok4uw	296	7	to	to	TO
cord-001835-0s7ok4uw	296	8	characterize	characterize	VB
cord-001835-0s7ok4uw	296	9	and	and	CC
cord-001835-0s7ok4uw	296	10	compare	compare	VB
cord-001835-0s7ok4uw	296	11	the	the	DT
cord-001835-0s7ok4uw	296	12	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	296	13	properties	property	NNS
cord-001835-0s7ok4uw	296	14	and	and	CC
cord-001835-0s7ok4uw	296	15	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	296	16	structure	structure	NN
cord-001835-0s7ok4uw	296	17	of	of	IN
cord-001835-0s7ok4uw	296	18	the	the	DT
cord-001835-0s7ok4uw	296	19	HtrA3	HtrA3	NNP
cord-001835-0s7ok4uw	296	20	isoforms	isoform	NNS
cord-001835-0s7ok4uw	296	21	.	.	.
cord-001835-0s7ok4uw	297	1	Both	both	DT
cord-001835-0s7ok4uw	297	2	studied	study	VBN
cord-001835-0s7ok4uw	297	3	isoforms	isoform	NNS
cord-001835-0s7ok4uw	297	4	lacked	lack	VBD
cord-001835-0s7ok4uw	297	5	the	the	DT
cord-001835-0s7ok4uw	297	6	N	n	CD
cord-001835-0s7ok4uw	297	7	-	-	HYPH
cord-001835-0s7ok4uw	297	8	terminal	terminal	NN
cord-001835-0s7ok4uw	297	9	domain	domain	NN
cord-001835-0s7ok4uw	297	10	.	.	.
cord-001835-0s7ok4uw	298	1	HtrA3	HtrA3	NNP
cord-001835-0s7ok4uw	298	2	with	with	IN
cord-001835-0s7ok4uw	298	3	the	the	DT
cord-001835-0s7ok4uw	298	4	PDZ	PDZ	NNP
cord-001835-0s7ok4uw	298	5	domain	domain	NN
cord-001835-0s7ok4uw	298	6	removed	remove	VBN
cord-001835-0s7ok4uw	298	7	(	(	-LRB-
cord-001835-0s7ok4uw	298	8	HtrA3-DPDZ	HtrA3-DPDZ	NNP
cord-001835-0s7ok4uw	298	9	)	)	-RRB-
cord-001835-0s7ok4uw	298	10	and	and	CC
cord-001835-0s7ok4uw	298	11	HtrA3S	HtrA3S	NNP
cord-001835-0s7ok4uw	298	12	(	(	-LRB-
cord-001835-0s7ok4uw	298	13	HtrA3S	HtrA3S	NNP
cord-001835-0s7ok4uw	298	14	)	)	-RRB-
cord-001835-0s7ok4uw	298	15	were	be	VBD
cord-001835-0s7ok4uw	298	16	fully	fully	RB
cord-001835-0s7ok4uw	298	17	active	active	JJ
cord-001835-0s7ok4uw	298	18	at	at	IN
cord-001835-0s7ok4uw	298	19	a	a	DT
cord-001835-0s7ok4uw	298	20	wide	wide	JJ
cord-001835-0s7ok4uw	298	21	range	range	NN
cord-001835-0s7ok4uw	298	22	of	of	IN
cord-001835-0s7ok4uw	298	23	temperatures	temperature	NNS
cord-001835-0s7ok4uw	298	24	and	and	CC
cord-001835-0s7ok4uw	298	25	their	-PRON-	PRP$
cord-001835-0s7ok4uw	298	26	substrate	substrate	NN
cord-001835-0s7ok4uw	298	27	affinity	affinity	NN
cord-001835-0s7ok4uw	298	28	was	be	VBD
cord-001835-0s7ok4uw	298	29	not	not	RB
cord-001835-0s7ok4uw	298	30	impaired	impaired	JJ
cord-001835-0s7ok4uw	298	31	.	.	.
cord-001835-0s7ok4uw	299	1	This	this	DT
cord-001835-0s7ok4uw	299	2	indicates	indicate	VBZ
cord-001835-0s7ok4uw	299	3	that	that	IN
cord-001835-0s7ok4uw	299	4	the	the	DT
cord-001835-0s7ok4uw	299	5	PDZ	PDZ	NNP
cord-001835-0s7ok4uw	299	6	domain	domain	NN
cord-001835-0s7ok4uw	299	7	is	be	VBZ
cord-001835-0s7ok4uw	299	8	dispensable	dispensable	JJ
cord-001835-0s7ok4uw	299	9	for	for	IN
cord-001835-0s7ok4uw	299	10	HtrA3	HtrA3	NNP
cord-001835-0s7ok4uw	299	11	activity	activity	NN
cord-001835-0s7ok4uw	299	12	.	.	.
cord-001835-0s7ok4uw	300	1	As	as	IN
cord-001835-0s7ok4uw	300	2	determined	determine	VBN
cord-001835-0s7ok4uw	300	3	by	by	IN
cord-001835-0s7ok4uw	300	4	size	size	NN
cord-001835-0s7ok4uw	300	5	exclusion	exclusion	NN
cord-001835-0s7ok4uw	300	6	chromatography	chromatography	NN
cord-001835-0s7ok4uw	300	7	,	,	,
cord-001835-0s7ok4uw	300	8	HtrA3	HtrA3	NNP
cord-001835-0s7ok4uw	300	9	formed	form	VBD
cord-001835-0s7ok4uw	300	10	stable	stable	JJ
cord-001835-0s7ok4uw	300	11	trimers	trimer	NNS
cord-001835-0s7ok4uw	300	12	while	while	IN
cord-001835-0s7ok4uw	300	13	both	both	DT
cord-001835-0s7ok4uw	300	14	HtrA3-DPDZ	HtrA3-DPDZ	NNP
cord-001835-0s7ok4uw	300	15	and	and	CC
cord-001835-0s7ok4uw	300	16	HtrA3S	HtrA3S	NNP
cord-001835-0s7ok4uw	300	17	were	be	VBD
cord-001835-0s7ok4uw	300	18	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	300	19	.	.	.
cord-001835-0s7ok4uw	301	1	This	this	DT
cord-001835-0s7ok4uw	301	2	suggests	suggest	VBZ
cord-001835-0s7ok4uw	301	3	that	that	IN
cord-001835-0s7ok4uw	301	4	the	the	DT
cord-001835-0s7ok4uw	301	5	presence	presence	NN
cord-001835-0s7ok4uw	301	6	of	of	IN
cord-001835-0s7ok4uw	301	7	the	the	DT
cord-001835-0s7ok4uw	301	8	PDZ	PDZ	NNP
cord-001835-0s7ok4uw	301	9	domain	domain	NN
cord-001835-0s7ok4uw	301	10	,	,	,
cord-001835-0s7ok4uw	301	11	unlike	unlike	IN
cord-001835-0s7ok4uw	301	12	in	in	IN
cord-001835-0s7ok4uw	301	13	other	other	JJ
cord-001835-0s7ok4uw	301	14	human	human	JJ
cord-001835-0s7ok4uw	301	15	HtrAs	htras	NN
cord-001835-0s7ok4uw	301	16	(	(	-LRB-
cord-001835-0s7ok4uw	301	17	HtrA1	HtrA1	NNP
cord-001835-0s7ok4uw	301	18	and	and	CC
cord-001835-0s7ok4uw	301	19	HtrA2	HtrA2	NNP
cord-001835-0s7ok4uw	301	20	)	)	-RRB-
cord-001835-0s7ok4uw	301	21	,	,	,
cord-001835-0s7ok4uw	301	22	influences	influence	VBZ
cord-001835-0s7ok4uw	301	23	HtrA3	HtrA3	NNP
cord-001835-0s7ok4uw	301	24	trimer	trimer	NN
cord-001835-0s7ok4uw	301	25	formation	formation	NN
cord-001835-0s7ok4uw	301	26	.	.	.
cord-001835-0s7ok4uw	302	1	The	the	DT
cord-001835-0s7ok4uw	302	2	unique	unique	JJ
cord-001835-0s7ok4uw	302	3	C	c	NN
cord-001835-0s7ok4uw	302	4	-	-	HYPH
cord-001835-0s7ok4uw	302	5	terminal	terminal	NN
cord-001835-0s7ok4uw	302	6	sequence	sequence	NN
cord-001835-0s7ok4uw	302	7	of	of	IN
cord-001835-0s7ok4uw	302	8	DN	DN	NNP
cord-001835-0s7ok4uw	302	9	-	-	HYPH
cord-001835-0s7ok4uw	302	10	HtrA3S	HtrA3S	NNP
cord-001835-0s7ok4uw	302	11	appeared	appear	VBD
cord-001835-0s7ok4uw	302	12	to	to	TO
cord-001835-0s7ok4uw	302	13	have	have	VB
cord-001835-0s7ok4uw	302	14	little	little	JJ
cord-001835-0s7ok4uw	302	15	effect	effect	NN
cord-001835-0s7ok4uw	302	16	on	on	IN
cord-001835-0s7ok4uw	302	17	activity	activity	NN
cord-001835-0s7ok4uw	302	18	and	and	CC
cord-001835-0s7ok4uw	302	19	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	302	20	[	[	-LRB-
cord-001835-0s7ok4uw	302	21	4	4	CD
cord-001835-0s7ok4uw	302	22	]	]	-RRB-
cord-001835-0s7ok4uw	302	23	.	.	.
cord-001835-0s7ok4uw	302	24	 	 	_SP
cord-001835-0s7ok4uw	303	1	Cyclodextrins	Cyclodextrins	NNP
cord-001835-0s7ok4uw	303	2	(	(	-LRB-
cord-001835-0s7ok4uw	303	3	CDs	cd	NNS
cord-001835-0s7ok4uw	303	4	)	)	-RRB-
cord-001835-0s7ok4uw	303	5	are	be	VBP
cord-001835-0s7ok4uw	303	6	cyclic	cyclic	JJ
cord-001835-0s7ok4uw	303	7	oligosaccharides	oligosaccharide	NNS
cord-001835-0s7ok4uw	303	8	that	that	WDT
cord-001835-0s7ok4uw	303	9	have	have	VBP
cord-001835-0s7ok4uw	303	10	been	be	VBN
cord-001835-0s7ok4uw	303	11	recognized	recognize	VBN
cord-001835-0s7ok4uw	303	12	as	as	IN
cord-001835-0s7ok4uw	303	13	useful	useful	JJ
cord-001835-0s7ok4uw	303	14	pharmaceutical	pharmaceutical	JJ
cord-001835-0s7ok4uw	303	15	excipients	excipient	NNS
cord-001835-0s7ok4uw	303	16	.	.	.
cord-001835-0s7ok4uw	304	1	In	in	IN
cord-001835-0s7ok4uw	304	2	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	304	3	solution	solution	NN
cord-001835-0s7ok4uw	304	4	CDs	cd	NNS
cord-001835-0s7ok4uw	304	5	are	be	VBP
cord-001835-0s7ok4uw	304	6	capable	capable	JJ
cord-001835-0s7ok4uw	304	7	to	to	TO
cord-001835-0s7ok4uw	304	8	form	form	VB
cord-001835-0s7ok4uw	304	9	complexes	complex	NNS
cord-001835-0s7ok4uw	304	10	with	with	IN
cord-001835-0s7ok4uw	304	11	various	various	JJ
cord-001835-0s7ok4uw	304	12	ligands	ligand	NNS
cord-001835-0s7ok4uw	304	13	,	,	,
cord-001835-0s7ok4uw	304	14	hosting	host	VBG
cord-001835-0s7ok4uw	304	15	inside	inside	IN
cord-001835-0s7ok4uw	304	16	their	-PRON-	PRP$
cord-001835-0s7ok4uw	304	17	cavity	cavity	NN
cord-001835-0s7ok4uw	304	18	either	either	CC
cord-001835-0s7ok4uw	304	19	a	a	DT
cord-001835-0s7ok4uw	304	20	whole	whole	JJ
cord-001835-0s7ok4uw	304	21	molecule	molecule	NN
cord-001835-0s7ok4uw	304	22	,	,	,
cord-001835-0s7ok4uw	304	23	or	or	CC
cord-001835-0s7ok4uw	304	24	part	part	NN
cord-001835-0s7ok4uw	304	25	of	of	IN
cord-001835-0s7ok4uw	304	26	a	a	DT
cord-001835-0s7ok4uw	304	27	ligand	ligand	NN
cord-001835-0s7ok4uw	304	28	.	.	.
cord-001835-0s7ok4uw	305	1	Inclusion	inclusion	NN
cord-001835-0s7ok4uw	305	2	complexes	complex	NNS
cord-001835-0s7ok4uw	305	3	with	with	IN
cord-001835-0s7ok4uw	305	4	CDs	cd	NNS
cord-001835-0s7ok4uw	305	5	offers	offer	VBZ
cord-001835-0s7ok4uw	305	6	a	a	DT
cord-001835-0s7ok4uw	305	7	variety	variety	NN
cord-001835-0s7ok4uw	305	8	of	of	IN
cord-001835-0s7ok4uw	305	9	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	305	10	advantages	advantage	NNS
cord-001835-0s7ok4uw	305	11	over	over	IN
cord-001835-0s7ok4uw	305	12	the	the	DT
cord-001835-0s7ok4uw	305	13	biologically	biologically	RB
cord-001835-0s7ok4uw	305	14	active	active	JJ
cord-001835-0s7ok4uw	305	15	ligands	ligand	NNS
cord-001835-0s7ok4uw	305	16	,	,	,
cord-001835-0s7ok4uw	305	17	including	include	VBG
cord-001835-0s7ok4uw	305	18	the	the	DT
cord-001835-0s7ok4uw	305	19	improved	improved	JJ
cord-001835-0s7ok4uw	305	20	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	305	21	solubility	solubility	NN
cord-001835-0s7ok4uw	305	22	,	,	,
cord-001835-0s7ok4uw	305	23	solution	solution	NN
cord-001835-0s7ok4uw	305	24	stability	stability	NN
cord-001835-0s7ok4uw	305	25	or	or	CC
cord-001835-0s7ok4uw	305	26	an	an	DT
cord-001835-0s7ok4uw	305	27	increase	increase	NN
cord-001835-0s7ok4uw	305	28	of	of	IN
cord-001835-0s7ok4uw	305	29	bioavailability	bioavailability	NN
cord-001835-0s7ok4uw	305	30	.	.	.
cord-001835-0s7ok4uw	306	1	CK2	CK2	NNP
cord-001835-0s7ok4uw	306	2	is	be	VBZ
cord-001835-0s7ok4uw	306	3	an	an	DT
cord-001835-0s7ok4uw	306	4	ubiquitous	ubiquitous	JJ
cord-001835-0s7ok4uw	306	5	,	,	,
cord-001835-0s7ok4uw	306	6	highly	highly	RB
cord-001835-0s7ok4uw	306	7	pleiotropic	pleiotropic	JJ
cord-001835-0s7ok4uw	306	8	and	and	CC
cord-001835-0s7ok4uw	306	9	constitutively	constitutively	RB
cord-001835-0s7ok4uw	306	10	active	active	JJ
cord-001835-0s7ok4uw	306	11	Ser	Ser	NNP
cord-001835-0s7ok4uw	306	12	/	/	SYM
cord-001835-0s7ok4uw	306	13	Thr	Thr	NNP
cord-001835-0s7ok4uw	306	14	protein	protein	NN
cord-001835-0s7ok4uw	306	15	kinase	kinase	NN
cord-001835-0s7ok4uw	306	16	.	.	.
cord-001835-0s7ok4uw	307	1	Halogenated	halogenated	JJ
cord-001835-0s7ok4uw	307	2	benzotriazoles	benzotriazole	NNS
cord-001835-0s7ok4uw	307	3	have	have	VBP
cord-001835-0s7ok4uw	307	4	been	be	VBN
cord-001835-0s7ok4uw	307	5	developed	develop	VBN
cord-001835-0s7ok4uw	307	6	as	as	IN
cord-001835-0s7ok4uw	307	7	potent	potent	JJ
cord-001835-0s7ok4uw	307	8	and	and	CC
cord-001835-0s7ok4uw	307	9	selective	selective	JJ
cord-001835-0s7ok4uw	307	10	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	307	11	of	of	IN
cord-001835-0s7ok4uw	307	12	this	this	DT
cord-001835-0s7ok4uw	307	13	enzyme	enzyme	NN
cord-001835-0s7ok4uw	307	14	.	.	.
cord-001835-0s7ok4uw	308	1	The	the	DT
cord-001835-0s7ok4uw	308	2	interaction	interaction	NN
cord-001835-0s7ok4uw	308	3	of	of	IN
cord-001835-0s7ok4uw	308	4	the	the	DT
cord-001835-0s7ok4uw	308	5	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	308	6	domain	domain	NN
cord-001835-0s7ok4uw	308	7	of	of	IN
cord-001835-0s7ok4uw	308	8	human	human	JJ
cord-001835-0s7ok4uw	308	9	protein	protein	NN
cord-001835-0s7ok4uw	308	10	kinase	kinase	NN
cord-001835-0s7ok4uw	308	11	CK2	CK2	NNP
cord-001835-0s7ok4uw	308	12	with	with	IN
cord-001835-0s7ok4uw	308	13	a	a	DT
cord-001835-0s7ok4uw	308	14	series	series	NN
cord-001835-0s7ok4uw	308	15	of	of	IN
cord-001835-0s7ok4uw	308	16	brominated	brominated	JJ
cord-001835-0s7ok4uw	308	17	ligands	ligand	NNS
cord-001835-0s7ok4uw	308	18	,	,	,
cord-001835-0s7ok4uw	308	19	which	which	WDT
cord-001835-0s7ok4uw	308	20	represent	represent	VBP
cord-001835-0s7ok4uw	308	21	all	all	DT
cord-001835-0s7ok4uw	308	22	possible	possible	JJ
cord-001835-0s7ok4uw	308	23	patterns	pattern	NNS
cord-001835-0s7ok4uw	308	24	of	of	IN
cord-001835-0s7ok4uw	308	25	halogen	halogen	NN
cord-001835-0s7ok4uw	308	26	substitutions	substitution	NNS
cord-001835-0s7ok4uw	308	27	to	to	IN
cord-001835-0s7ok4uw	308	28	the	the	DT
cord-001835-0s7ok4uw	308	29	benzene	benzene	NN
cord-001835-0s7ok4uw	308	30	ring	ring	NN
cord-001835-0s7ok4uw	308	31	of	of	IN
cord-001835-0s7ok4uw	308	32	benzotriazole	benzotriazole	NNP
cord-001835-0s7ok4uw	308	33	,	,	,
cord-001835-0s7ok4uw	308	34	was	be	VBD
cord-001835-0s7ok4uw	308	35	previously	previously	RB
cord-001835-0s7ok4uw	308	36	studied	study	VBN
cord-001835-0s7ok4uw	308	37	by	by	IN
cord-001835-0s7ok4uw	308	38	microscale	microscale	JJ
cord-001835-0s7ok4uw	308	39	thermophoresis	thermophoresis	NNP
cord-001835-0s7ok4uw	308	40	(	(	-LRB-
cord-001835-0s7ok4uw	308	41	MST	MST	NNP
cord-001835-0s7ok4uw	308	42	)	)	-RRB-
cord-001835-0s7ok4uw	308	43	[	[	-LRB-
cord-001835-0s7ok4uw	308	44	1	1	CD
cord-001835-0s7ok4uw	308	45	]	]	-RRB-
cord-001835-0s7ok4uw	308	46	.	.	.
cord-001835-0s7ok4uw	309	1	This	this	DT
cord-001835-0s7ok4uw	309	2	method	method	NN
cord-001835-0s7ok4uw	309	3	alloweddetermination	alloweddetermination	NN
cord-001835-0s7ok4uw	309	4	of	of	IN
cord-001835-0s7ok4uw	309	5	binding	bind	VBG
cord-001835-0s7ok4uw	309	6	affinities	affinity	NNS
cord-001835-0s7ok4uw	309	7	for	for	IN
cord-001835-0s7ok4uw	309	8	seven	seven	CD
cord-001835-0s7ok4uw	309	9	ligands	ligand	NNS
cord-001835-0s7ok4uw	309	10	,	,	,
cord-001835-0s7ok4uw	309	11	all	all	DT
cord-001835-0s7ok4uw	309	12	of	of	IN
cord-001835-0s7ok4uw	309	13	which	which	WDT
cord-001835-0s7ok4uw	309	14	were	be	VBD
cord-001835-0s7ok4uw	309	15	found	find	VBN
cord-001835-0s7ok4uw	309	16	consistent	consistent	JJ
cord-001835-0s7ok4uw	309	17	with	with	IN
cord-001835-0s7ok4uw	309	18	the	the	DT
cord-001835-0s7ok4uw	309	19	values	value	NNS
cord-001835-0s7ok4uw	309	20	determined	determine	VBN
cord-001835-0s7ok4uw	309	21	independently	independently	RB
cord-001835-0s7ok4uw	309	22	by	by	IN
cord-001835-0s7ok4uw	309	23	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	309	24	titration	titration	NN
cord-001835-0s7ok4uw	309	25	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	309	26	(	(	-LRB-
cord-001835-0s7ok4uw	309	27	ITC	ITC	NNP
cord-001835-0s7ok4uw	309	28	)	)	-RRB-
cord-001835-0s7ok4uw	309	29	.	.	.
cord-001835-0s7ok4uw	310	1	However	however	RB
cord-001835-0s7ok4uw	310	2	,	,	,
cord-001835-0s7ok4uw	310	3	a	a	DT
cord-001835-0s7ok4uw	310	4	very	very	RB
cord-001835-0s7ok4uw	310	5	limited	limited	JJ
cord-001835-0s7ok4uw	310	6	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	310	7	solubility	solubility	NN
cord-001835-0s7ok4uw	310	8	of	of	IN
cord-001835-0s7ok4uw	310	9	some	some	DT
cord-001835-0s7ok4uw	310	10	brominated	brominate	VBN
cord-001835-0s7ok4uw	310	11	benzotriazoles	benzotriazole	NNS
cord-001835-0s7ok4uw	310	12	may	may	MD
cord-001835-0s7ok4uw	310	13	decrease	decrease	VB
cord-001835-0s7ok4uw	310	14	their	-PRON-	PRP$
cord-001835-0s7ok4uw	310	15	bioavability	bioavability	NN
cord-001835-0s7ok4uw	310	16	,	,	,
cord-001835-0s7ok4uw	310	17	thus	thus	RB
cord-001835-0s7ok4uw	310	18	affectingtheir	affectingtheir	VB
cord-001835-0s7ok4uw	310	19	apparent	apparent	JJ
cord-001835-0s7ok4uw	310	20	activity	activity	NN
cord-001835-0s7ok4uw	310	21	[	[	-LRB-
cord-001835-0s7ok4uw	310	22	2	2	CD
cord-001835-0s7ok4uw	310	23	]	]	-RRB-
cord-001835-0s7ok4uw	310	24	.	.	.
cord-001835-0s7ok4uw	311	1	To	to	TO
cord-001835-0s7ok4uw	311	2	overcome	overcome	VB
cord-001835-0s7ok4uw	311	3	this	this	DT
cord-001835-0s7ok4uw	311	4	limitation	limitation	NN
cord-001835-0s7ok4uw	311	5	,	,	,
cord-001835-0s7ok4uw	311	6	the	the	DT
cord-001835-0s7ok4uw	311	7	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	311	8	solubility	solubility	NN
cord-001835-0s7ok4uw	311	9	of	of	IN
cord-001835-0s7ok4uw	311	10	halogenated	halogenate	VBN
cord-001835-0s7ok4uw	311	11	benzotriazoles	benzotriazole	NNS
cord-001835-0s7ok4uw	311	12	in	in	IN
cord-001835-0s7ok4uw	311	13	the	the	DT
cord-001835-0s7ok4uw	311	14	presence	presence	NN
cord-001835-0s7ok4uw	311	15	of	of	IN
cord-001835-0s7ok4uw	311	16	cyclodextrins	cyclodextrin	NNS
cord-001835-0s7ok4uw	311	17	has	have	VBZ
cord-001835-0s7ok4uw	311	18	been	be	VBN
cord-001835-0s7ok4uw	311	19	tested	test	VBN
cord-001835-0s7ok4uw	311	20	.	.	.
cord-001835-0s7ok4uw	312	1	The	the	DT
cord-001835-0s7ok4uw	312	2	formation	formation	NN
cord-001835-0s7ok4uw	312	3	of	of	IN
cord-001835-0s7ok4uw	312	4	inclusion	inclusion	NN
cord-001835-0s7ok4uw	312	5	complexes	complex	NNS
cord-001835-0s7ok4uw	312	6	with	with	IN
cord-001835-0s7ok4uw	312	7	b	b	NN
cord-001835-0s7ok4uw	312	8	-	-	HYPH
cord-001835-0s7ok4uw	312	9	cyclodextrin	cyclodextrin	NN
cord-001835-0s7ok4uw	312	10	(	(	-LRB-
cord-001835-0s7ok4uw	312	11	b	b	NN
cord-001835-0s7ok4uw	312	12	-	-	:
cord-001835-0s7ok4uw	312	13	CD	CD	NNP
cord-001835-0s7ok4uw	312	14	)	)	-RRB-
cord-001835-0s7ok4uw	312	15	,	,	,
cord-001835-0s7ok4uw	312	16	hydroxypropylb	hydroxypropylb	NN
cord-001835-0s7ok4uw	312	17	-	-	HYPH
cord-001835-0s7ok4uw	312	18	cyclodextrin	cyclodextrin	NN
cord-001835-0s7ok4uw	312	19	(	(	-LRB-
cord-001835-0s7ok4uw	312	20	HP	HP	NNP
cord-001835-0s7ok4uw	312	21	-	-	HYPH
cord-001835-0s7ok4uw	312	22	b	b	NNP
cord-001835-0s7ok4uw	312	23	-	-	HYPH
cord-001835-0s7ok4uw	312	24	CD	CD	NNP
cord-001835-0s7ok4uw	312	25	)	)	-RRB-
cord-001835-0s7ok4uw	312	26	and	and	CC
cord-001835-0s7ok4uw	312	27	g	g	NN
cord-001835-0s7ok4uw	312	28	-	-	HYPH
cord-001835-0s7ok4uw	312	29	cyclodextrin	cyclodextrin	NN
cord-001835-0s7ok4uw	312	30	(	(	-LRB-
cord-001835-0s7ok4uw	312	31	g	g	NN
cord-001835-0s7ok4uw	312	32	-	-	HYPH
cord-001835-0s7ok4uw	312	33	CD	CD	NNP
cord-001835-0s7ok4uw	312	34	)	)	-RRB-
cord-001835-0s7ok4uw	312	35	in	in	IN
cord-001835-0s7ok4uw	312	36	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	312	37	solutions	solution	NNS
cord-001835-0s7ok4uw	312	38	,	,	,
cord-001835-0s7ok4uw	312	39	followed	follow	VBN
cord-001835-0s7ok4uw	312	40	by	by	IN
cord-001835-0s7ok4uw	312	41	UV	uv	NN
cord-001835-0s7ok4uw	312	42	-	-	HYPH
cord-001835-0s7ok4uw	312	43	Vis	vis	NN
cord-001835-0s7ok4uw	312	44	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	312	45	,	,	,
cord-001835-0s7ok4uw	312	46	substantially	substantially	RB
cord-001835-0s7ok4uw	312	47	improved	improve	VBD
cord-001835-0s7ok4uw	312	48	the	the	DT
cord-001835-0s7ok4uw	312	49	solubility	solubility	NN
cord-001835-0s7ok4uw	312	50	of	of	IN
cord-001835-0s7ok4uw	312	51	TBBt	TBBt	NNS
cord-001835-0s7ok4uw	312	52	and	and	CC
cord-001835-0s7ok4uw	312	53	its	-PRON-	PRP$
cord-001835-0s7ok4uw	312	54	derivatives	derivative	NNS
cord-001835-0s7ok4uw	312	55	.	.	.
cord-001835-0s7ok4uw	313	1	The	the	DT
cord-001835-0s7ok4uw	313	2	interaction	interaction	NN
cord-001835-0s7ok4uw	313	3	between	between	IN
cord-001835-0s7ok4uw	313	4	protein	protein	NN
cord-001835-0s7ok4uw	313	5	kinase	kinase	NN
cord-001835-0s7ok4uw	313	6	CK2	CK2	NNP
cord-001835-0s7ok4uw	313	7	and	and	CC
cord-001835-0s7ok4uw	313	8	cyclodextrins	cyclodextrin	NNS
cord-001835-0s7ok4uw	313	9	,	,	,
cord-001835-0s7ok4uw	313	10	and	and	CC
cord-001835-0s7ok4uw	313	11	also	also	RB
cord-001835-0s7ok4uw	313	12	with	with	IN
cord-001835-0s7ok4uw	313	13	their	-PRON-	PRP$
cord-001835-0s7ok4uw	313	14	inclusion	inclusion	NN
cord-001835-0s7ok4uw	313	15	complexes	complex	NNS
cord-001835-0s7ok4uw	313	16	with	with	IN
cord-001835-0s7ok4uw	313	17	halogenated	halogenate	VBN
cord-001835-0s7ok4uw	313	18	benzotriazoles	benzotriazole	NNS
cord-001835-0s7ok4uw	313	19	,	,	,
cord-001835-0s7ok4uw	313	20	was	be	VBD
cord-001835-0s7ok4uw	313	21	followed	follow	VBN
cord-001835-0s7ok4uw	313	22	with	with	IN
cord-001835-0s7ok4uw	313	23	the	the	DT
cord-001835-0s7ok4uw	313	24	aid	aid	NN
cord-001835-0s7ok4uw	313	25	of	of	IN
cord-001835-0s7ok4uw	313	26	the	the	DT
cord-001835-0s7ok4uw	313	27	microscale	microscale	JJ
cord-001835-0s7ok4uw	313	28	thermophoresis	thermophoresis	NN
cord-001835-0s7ok4uw	313	29	.	.	.
cord-001835-0s7ok4uw	314	1	The	the	DT
cord-001835-0s7ok4uw	314	2	results	result	NNS
cord-001835-0s7ok4uw	314	3	obtained	obtain	VBN
cord-001835-0s7ok4uw	314	4	clearly	clearly	RB
cord-001835-0s7ok4uw	314	5	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	314	6	that	that	IN
cord-001835-0s7ok4uw	314	7	the	the	DT
cord-001835-0s7ok4uw	314	8	binding	binding	NN
cord-001835-0s7ok4uw	314	9	of	of	IN
cord-001835-0s7ok4uw	314	10	halogenated	halogenate	VBN
cord-001835-0s7ok4uw	314	11	benzotriazoles	benzotriazole	NNS
cord-001835-0s7ok4uw	314	12	by	by	IN
cord-001835-0s7ok4uw	314	13	CK2	CK2	NNP
cord-001835-0s7ok4uw	314	14	is	be	VBZ
cord-001835-0s7ok4uw	314	15	only	only	RB
cord-001835-0s7ok4uw	314	16	moderately	moderately	RB
cord-001835-0s7ok4uw	314	17	affected	affect	VBN
cord-001835-0s7ok4uw	314	18	by	by	IN
cord-001835-0s7ok4uw	314	19	cyclodextrins	cyclodextrin	NNS
cord-001835-0s7ok4uw	314	20	.	.	.
cord-001835-0s7ok4uw	314	21	 	 	_SP
cord-001835-0s7ok4uw	315	1	Oligonucleotide	Oligonucleotide	NNP
cord-001835-0s7ok4uw	315	2	-	-	HYPH
cord-001835-0s7ok4uw	315	3	based	base	VBN
cord-001835-0s7ok4uw	315	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	315	5	circuits	circuit	NNS
cord-001835-0s7ok4uw	315	6	offer	offer	VBP
cord-001835-0s7ok4uw	315	7	the	the	DT
cord-001835-0s7ok4uw	315	8	exciting	exciting	JJ
cord-001835-0s7ok4uw	315	9	possibility	possibility	NN
cord-001835-0s7ok4uw	315	10	to	to	TO
cord-001835-0s7ok4uw	315	11	introduce	introduce	VB
cord-001835-0s7ok4uw	315	12	autonomous	autonomous	JJ
cord-001835-0s7ok4uw	315	13	signal	signal	NN
cord-001835-0s7ok4uw	315	14	processing	processing	NN
cord-001835-0s7ok4uw	315	15	in	in	IN
cord-001835-0s7ok4uw	315	16	biomedicine	biomedicine	NN
cord-001835-0s7ok4uw	315	17	,	,	,
cord-001835-0s7ok4uw	315	18	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	315	19	biology	biology	NN
cord-001835-0s7ok4uw	315	20	,	,	,
cord-001835-0s7ok4uw	315	21	and	and	CC
cord-001835-0s7ok4uw	315	22	molecular	molecular	JJ
cord-001835-0s7ok4uw	315	23	diagnostics	diagnostic	NNS
cord-001835-0s7ok4uw	315	24	.	.	.
cord-001835-0s7ok4uw	316	1	Here	here	RB
cord-001835-0s7ok4uw	316	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	316	3	introduce	introduce	VBP
cord-001835-0s7ok4uw	316	4	bivalent	bivalent	JJ
cord-001835-0s7ok4uw	316	5	peptide	peptide	NN
cord-001835-0s7ok4uw	316	6	-	-	HYPH
cord-001835-0s7ok4uw	316	7	DNA	dna	NN
cord-001835-0s7ok4uw	316	8	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	316	9	as	as	IN
cord-001835-0s7ok4uw	316	10	generic	generic	JJ
cord-001835-0s7ok4uw	316	11	,	,	,
cord-001835-0s7ok4uw	316	12	noncovalent	noncovalent	JJ
cord-001835-0s7ok4uw	316	13	,	,	,
cord-001835-0s7ok4uw	316	14	and	and	CC
cord-001835-0s7ok4uw	316	15	easily	easily	RB
cord-001835-0s7ok4uw	316	16	applicable	applicable	JJ
cord-001835-0s7ok4uw	316	17	molecular	molecular	JJ
cord-001835-0s7ok4uw	316	18	locks	lock	NNS
cord-001835-0s7ok4uw	316	19	that	that	WDT
cord-001835-0s7ok4uw	316	20	allow	allow	VBP
cord-001835-0s7ok4uw	316	21	the	the	DT
cord-001835-0s7ok4uw	316	22	control	control	NN
cord-001835-0s7ok4uw	316	23	of	of	IN
cord-001835-0s7ok4uw	316	24	antibody	antibody	NN
cord-001835-0s7ok4uw	316	25	activity	activity	NN
cord-001835-0s7ok4uw	316	26	using	use	VBG
cord-001835-0s7ok4uw	316	27	toeholdmediated	toeholdmediate	VBN
cord-001835-0s7ok4uw	316	28	strand	strand	NN
cord-001835-0s7ok4uw	316	29	displacement	displacement	NN
cord-001835-0s7ok4uw	316	30	reactions	reaction	NNS
cord-001835-0s7ok4uw	316	31	.	.	.
cord-001835-0s7ok4uw	317	1	Employing	employ	VBG
cord-001835-0s7ok4uw	317	2	yeast	yeast	NN
cord-001835-0s7ok4uw	317	3	as	as	IN
cord-001835-0s7ok4uw	317	4	a	a	DT
cord-001835-0s7ok4uw	317	5	cellular	cellular	JJ
cord-001835-0s7ok4uw	317	6	model	model	NN
cord-001835-0s7ok4uw	317	7	system	system	NN
cord-001835-0s7ok4uw	317	8	,	,	,
cord-001835-0s7ok4uw	317	9	reversible	reversible	JJ
cord-001835-0s7ok4uw	317	10	control	control	NN
cord-001835-0s7ok4uw	317	11	of	of	IN
cord-001835-0s7ok4uw	317	12	antibody	antibody	NN
cord-001835-0s7ok4uw	317	13	targeting	targeting	NN
cord-001835-0s7ok4uw	317	14	is	be	VBZ
cord-001835-0s7ok4uw	317	15	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	317	16	with	with	IN
cord-001835-0s7ok4uw	317	17	low	low	JJ
cord-001835-0s7ok4uw	317	18	nm	nm	NNP
cord-001835-0s7ok4uw	317	19	concentrations	concentration	NNS
cord-001835-0s7ok4uw	317	20	of	of	IN
cord-001835-0s7ok4uw	317	21	peptide	peptide	JJ
cord-001835-0s7ok4uw	317	22	-	-	HYPH
cord-001835-0s7ok4uw	317	23	DNA	dna	NN
cord-001835-0s7ok4uw	317	24	locks	lock	NNS
cord-001835-0s7ok4uw	317	25	and	and	CC
cord-001835-0s7ok4uw	317	26	oligonucleotide	oligonucleotide	JJ
cord-001835-0s7ok4uw	317	27	displacer	displacer	NN
cord-001835-0s7ok4uw	317	28	strands	strand	NNS
cord-001835-0s7ok4uw	317	29	.	.	.
cord-001835-0s7ok4uw	318	1	Introduction	introduction	NN
cord-001835-0s7ok4uw	318	2	of	of	IN
cord-001835-0s7ok4uw	318	3	two	two	CD
cord-001835-0s7ok4uw	318	4	different	different	JJ
cord-001835-0s7ok4uw	318	5	toehold	toehold	NN
cord-001835-0s7ok4uw	318	6	strands	strand	NNS
cord-001835-0s7ok4uw	318	7	on	on	IN
cord-001835-0s7ok4uw	318	8	the	the	DT
cord-001835-0s7ok4uw	318	9	peptide	peptide	JJ
cord-001835-0s7ok4uw	318	10	-	-	HYPH
cord-001835-0s7ok4uw	318	11	DNA	dna	NN
cord-001835-0s7ok4uw	318	12	lock	lock	NN
cord-001835-0s7ok4uw	318	13	allowed	allow	VBN
cord-001835-0s7ok4uw	318	14	signal	signal	NN
cord-001835-0s7ok4uw	318	15	integration	integration	NN
cord-001835-0s7ok4uw	318	16	of	of	IN
cord-001835-0s7ok4uw	318	17	two	two	CD
cord-001835-0s7ok4uw	318	18	different	different	JJ
cord-001835-0s7ok4uw	318	19	inputs	input	NNS
cord-001835-0s7ok4uw	318	20	,	,	,
cord-001835-0s7ok4uw	318	21	yielding	yield	VBG
cord-001835-0s7ok4uw	318	22	logic	logic	NN
cord-001835-0s7ok4uw	318	23	ORand	orand	JJ
cord-001835-0s7ok4uw	318	24	AND	and	CC
cord-001835-0s7ok4uw	318	25	-	-	HYPH
cord-001835-0s7ok4uw	318	26	gates	gate	NNS
cord-001835-0s7ok4uw	318	27	.	.	.
cord-001835-0s7ok4uw	319	1	The	the	DT
cord-001835-0s7ok4uw	319	2	range	range	NN
cord-001835-0s7ok4uw	319	3	of	of	IN
cord-001835-0s7ok4uw	319	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	319	5	inputs	input	NNS
cord-001835-0s7ok4uw	319	6	could	could	MD
cord-001835-0s7ok4uw	319	7	be	be	VB
cord-001835-0s7ok4uw	319	8	further	further	RB
cord-001835-0s7ok4uw	319	9	extended	extend	VBN
cord-001835-0s7ok4uw	319	10	to	to	IN
cord-001835-0s7ok4uw	319	11	protein	protein	NN
cord-001835-0s7ok4uw	319	12	-	-	HYPH
cord-001835-0s7ok4uw	319	13	based	base	VBN
cord-001835-0s7ok4uw	319	14	triggers	trigger	NNS
cord-001835-0s7ok4uw	319	15	by	by	IN
cord-001835-0s7ok4uw	319	16	using	use	VBG
cord-001835-0s7ok4uw	319	17	proteinbinding	proteinbinde	VBG
cord-001835-0s7ok4uw	319	18	aptamers	aptamer	NNS
cord-001835-0s7ok4uw	319	19	.	.	.
cord-001835-0s7ok4uw	320	1	Insights	insight	NNS
cord-001835-0s7ok4uw	320	2	of	of	IN
cord-001835-0s7ok4uw	320	3	a	a	DT
cord-001835-0s7ok4uw	320	4	novel	novel	JJ
cord-001835-0s7ok4uw	320	5	kind	kind	NN
cord-001835-0s7ok4uw	320	6	of	of	IN
cord-001835-0s7ok4uw	320	7	cell	cell	NN
cord-001835-0s7ok4uw	320	8	wall	wall	NN
cord-001835-0s7ok4uw	320	9	binding	bind	VBG
cord-001835-0s7ok4uw	320	10	domain	domain	NN
cord-001835-0s7ok4uw	320	11	that	that	WDT
cord-001835-0s7ok4uw	320	12	cleaves	cleave	VBZ
cord-001835-0s7ok4uw	320	13	the	the	DT
cord-001835-0s7ok4uw	320	14	peptidoglycan	peptidoglycan	NN
cord-001835-0s7ok4uw	320	15	muropeptide	muropeptide	NNP
cord-001835-0s7ok4uw	320	16	:	:	:
cord-001835-0s7ok4uw	320	17	the	the	DT
cord-001835-0s7ok4uw	320	18	CW_7	CW_7	NNP
cord-001835-0s7ok4uw	320	19	motif	motif	NN
cord-001835-0s7ok4uw	321	1	Noem	Noem	NNP
cord-001835-0s7ok4uw	321	2	ı	ı	NNP
cord-001835-0s7ok4uw	322	1	Bustamante	Bustamante	NNP
cord-001835-0s7ok4uw	322	2	1,3	1,3	CD
cord-001835-0s7ok4uw	322	3	,	,	,
cord-001835-0s7ok4uw	322	4	Manuel	Manuel	NNP
cord-001835-0s7ok4uw	322	5	Iglesias	Iglesias	NNP
cord-001835-0s7ok4uw	322	6	,	,	,
cord-001835-0s7ok4uw	322	7	Noella	Noella	NNP
cord-001835-0s7ok4uw	322	8	Silva	Silva	NNP
cord-001835-0s7ok4uw	322	9	-	-	HYPH
cord-001835-0s7ok4uw	322	10	Mart	Mart	NNP
cord-001835-0s7ok4uw	322	11	ın	ın	RB
cord-001835-0s7ok4uw	322	12	,	,	,
cord-001835-0s7ok4uw	322	13	Isabel	Isabel	NNP
cord-001835-0s7ok4uw	322	14	Uson	Uson	NNP
cord-001835-0s7ok4uw	322	15	,	,	,
cord-001835-0s7ok4uw	322	16	Pedro	Pedro	NNP
cord-001835-0s7ok4uw	322	17	Garc	Garc	NNP
cord-001835-0s7ok4uw	322	18	ıa	ıa	VBZ
cord-001835-0s7ok4uw	322	19	,	,	,
cord-001835-0s7ok4uw	322	20	Juan	Juan	NNP
cord-001835-0s7ok4uw	322	21	Hermoso	Hermoso	NNP
cord-001835-0s7ok4uw	322	22	,	,	,
cord-001835-0s7ok4uw	322	23	Marta	Marta	NNP
cord-001835-0s7ok4uw	322	24	Bruix	Bruix	NNP
cord-001835-0s7ok4uw	322	25	,	,	,
cord-001835-0s7ok4uw	322	26	Margarita	Margarita	NNP
cord-001835-0s7ok4uw	322	27	Men	Men	NNPS
cord-001835-0s7ok4uw	322	28	endez	endez	NNP
cord-001835-0s7ok4uw	322	29	1	1	CD
cord-001835-0s7ok4uw	322	30	Institute	Institute	NNP
cord-001835-0s7ok4uw	322	31	of	of	IN
cord-001835-0s7ok4uw	322	32	Physical	Physical	NNP
cord-001835-0s7ok4uw	322	33	-	-	HYPH
cord-001835-0s7ok4uw	322	34	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	322	35	'	'	''
cord-001835-0s7ok4uw	322	36	Rocasolano	Rocasolano	NNP
cord-001835-0s7ok4uw	322	37	'	'	''
cord-001835-0s7ok4uw	322	38	,	,	,
cord-001835-0s7ok4uw	322	39	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	322	40	,	,	,
cord-001835-0s7ok4uw	322	41	2	2	CD
cord-001835-0s7ok4uw	322	42	Institute	Institute	NNP
cord-001835-0s7ok4uw	322	43	of	of	IN
cord-001835-0s7ok4uw	322	44	Physical	Physical	NNP
cord-001835-0s7ok4uw	322	45	-	-	HYPH
cord-001835-0s7ok4uw	322	46	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	322	47	'	'	''
cord-001835-0s7ok4uw	322	48	Rocasolano	Rocasolano	NNP
cord-001835-0s7ok4uw	322	49	'	'	''
cord-001835-0s7ok4uw	322	50	,	,	,
cord-001835-0s7ok4uw	322	51	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	322	52	,	,	,
cord-001835-0s7ok4uw	322	53	3	3	CD
cord-001835-0s7ok4uw	322	54	Ciber	Ciber	NNP
cord-001835-0s7ok4uw	322	55	of	of	IN
cord-001835-0s7ok4uw	322	56	Respiratory	Respiratory	NNP
cord-001835-0s7ok4uw	322	57	Diseases	Diseases	NNPS
cord-001835-0s7ok4uw	322	58	(	(	-LRB-
cord-001835-0s7ok4uw	322	59	CIBERES	CIBERES	NNP
cord-001835-0s7ok4uw	322	60	)	)	-RRB-
cord-001835-0s7ok4uw	322	61	,	,	,
cord-001835-0s7ok4uw	322	62	4	4	CD
cord-001835-0s7ok4uw	322	63	Center	Center	NNP
cord-001835-0s7ok4uw	322	64	of	of	IN
cord-001835-0s7ok4uw	322	65	Biological	Biological	NNP
cord-001835-0s7ok4uw	322	66	Research	Research	NNP
cord-001835-0s7ok4uw	322	67	(	(	-LRB-
cord-001835-0s7ok4uw	322	68	CIB	CIB	NNP
cord-001835-0s7ok4uw	322	69	)	)	-RRB-
cord-001835-0s7ok4uw	322	70	,	,	,
cord-001835-0s7ok4uw	322	71	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	322	72	,	,	,
cord-001835-0s7ok4uw	322	73	5	5	CD
cord-001835-0s7ok4uw	322	74	 	 	_SP
cord-001835-0s7ok4uw	322	75	Enzybiotics	Enzybiotics	NNP
cord-001835-0s7ok4uw	322	76	constitute	constitute	VBP
cord-001835-0s7ok4uw	322	77	a	a	DT
cord-001835-0s7ok4uw	322	78	hopeful	hopeful	JJ
cord-001835-0s7ok4uw	322	79	alternative	alternative	NN
cord-001835-0s7ok4uw	322	80	to	to	IN
cord-001835-0s7ok4uw	322	81	current	current	JJ
cord-001835-0s7ok4uw	322	82	treatments	treatment	NNS
cord-001835-0s7ok4uw	322	83	to	to	TO
cord-001835-0s7ok4uw	322	84	fight	fight	VB
cord-001835-0s7ok4uw	322	85	against	against	IN
cord-001835-0s7ok4uw	322	86	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	322	87	infections	infection	NNS
cord-001835-0s7ok4uw	322	88	.	.	.
cord-001835-0s7ok4uw	323	1	Phage	phage	NN
cord-001835-0s7ok4uw	323	2	endolysins	endolysin	NNS
cord-001835-0s7ok4uw	323	3	are	be	VBP
cord-001835-0s7ok4uw	323	4	consider	consider	JJ
cord-001835-0s7ok4uw	323	5	as	as	IN
cord-001835-0s7ok4uw	323	6	enzybiotics	enzybiotic	NNS
cord-001835-0s7ok4uw	323	7	due	due	IN
cord-001835-0s7ok4uw	323	8	to	to	IN
cord-001835-0s7ok4uw	323	9	their	-PRON-	PRP$
cord-001835-0s7ok4uw	323	10	capacity	capacity	NN
cord-001835-0s7ok4uw	323	11	to	to	TO
cord-001835-0s7ok4uw	323	12	cleave	cleave	VB
cord-001835-0s7ok4uw	323	13	the	the	DT
cord-001835-0s7ok4uw	323	14	peptidoglycan	peptidoglycan	NN
cord-001835-0s7ok4uw	323	15	(	(	-LRB-
cord-001835-0s7ok4uw	323	16	PG	PG	NNP
cord-001835-0s7ok4uw	323	17	)	)	-RRB-
cord-001835-0s7ok4uw	323	18	of	of	IN
cord-001835-0s7ok4uw	323	19	Gram	gram	NN
cord-001835-0s7ok4uw	323	20	-	-	HYPH
cord-001835-0s7ok4uw	323	21	positive	positive	JJ
cord-001835-0s7ok4uw	323	22	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	323	23	in	in	IN
cord-001835-0s7ok4uw	323	24	a	a	DT
cord-001835-0s7ok4uw	323	25	generally	generally	RB
cord-001835-0s7ok4uw	323	26	species	species	NN
cord-001835-0s7ok4uw	323	27	-	-	HYPH
cord-001835-0s7ok4uw	323	28	specific	specific	JJ
cord-001835-0s7ok4uw	323	29	manner	manner	NN
cord-001835-0s7ok4uw	323	30	and	and	CC
cord-001835-0s7ok4uw	323	31	kill	kill	VB
cord-001835-0s7ok4uw	323	32	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	323	33	when	when	WRB
cord-001835-0s7ok4uw	323	34	exogenously	exogenously	RB
cord-001835-0s7ok4uw	323	35	added	add	VBN
cord-001835-0s7ok4uw	323	36	(	(	-LRB-
cord-001835-0s7ok4uw	323	37	1	1	CD
cord-001835-0s7ok4uw	323	38	,	,	,
cord-001835-0s7ok4uw	323	39	2	2	CD
cord-001835-0s7ok4uw	323	40	)	)	-RRB-
cord-001835-0s7ok4uw	323	41	.	.	.
cord-001835-0s7ok4uw	324	1	The	the	DT
cord-001835-0s7ok4uw	324	2	Cpl-7	Cpl-7	NNP
cord-001835-0s7ok4uw	324	3	endolysin	endolysin	NN
cord-001835-0s7ok4uw	324	4	,	,	,
cord-001835-0s7ok4uw	324	5	a	a	DT
cord-001835-0s7ok4uw	324	6	lysozyme	lysozyme	NN
cord-001835-0s7ok4uw	324	7	encoded	encode	VBN
cord-001835-0s7ok4uw	324	8	by	by	IN
cord-001835-0s7ok4uw	324	9	the	the	DT
cord-001835-0s7ok4uw	324	10	pneumococcal	pneumococcal	JJ
cord-001835-0s7ok4uw	324	11	Cp-7	Cp-7	NNP
cord-001835-0s7ok4uw	324	12	bacteriophage	bacteriophage	NN
cord-001835-0s7ok4uw	324	13	,	,	,
cord-001835-0s7ok4uw	324	14	is	be	VBZ
cord-001835-0s7ok4uw	324	15	a	a	DT
cord-001835-0s7ok4uw	324	16	remarkable	remarkable	JJ
cord-001835-0s7ok4uw	324	17	exception	exception	NN
cord-001835-0s7ok4uw	324	18	among	among	IN
cord-001835-0s7ok4uw	324	19	all	all	PDT
cord-001835-0s7ok4uw	324	20	the	the	DT
cord-001835-0s7ok4uw	324	21	PG	PG	NNP
cord-001835-0s7ok4uw	324	22	hydrolases	hydrolase	NNS
cord-001835-0s7ok4uw	324	23	produced	produce	VBN
cord-001835-0s7ok4uw	324	24	by	by	IN
cord-001835-0s7ok4uw	324	25	Streptococcus	Streptococcus	NNP
cord-001835-0s7ok4uw	324	26	pneumoniae	pneumoniae	NN
cord-001835-0s7ok4uw	324	27	and	and	CC
cord-001835-0s7ok4uw	324	28	its	-PRON-	PRP$
cord-001835-0s7ok4uw	324	29	bacteriophages	bacteriophage	NNS
cord-001835-0s7ok4uw	324	30	due	due	JJ
cord-001835-0s7ok4uw	324	31	to	to	IN
cord-001835-0s7ok4uw	324	32	its	-PRON-	PRP$
cord-001835-0s7ok4uw	324	33	capacity	capacity	NN
cord-001835-0s7ok4uw	324	34	of	of	IN
cord-001835-0s7ok4uw	324	35	degrading	degrade	VBG
cord-001835-0s7ok4uw	324	36	pneumococcal	pneumococcal	JJ
cord-001835-0s7ok4uw	324	37	cell	cell	NN
cord-001835-0s7ok4uw	324	38	walls	wall	NNS
cord-001835-0s7ok4uw	324	39	containing	contain	VBG
cord-001835-0s7ok4uw	324	40	either	either	CC
cord-001835-0s7ok4uw	324	41	choline	choline	NN
cord-001835-0s7ok4uw	324	42	or	or	CC
cord-001835-0s7ok4uw	324	43	ethanolamine	ethanolamine	NN
cord-001835-0s7ok4uw	324	44	(	(	-LRB-
cord-001835-0s7ok4uw	324	45	3	3	CD
cord-001835-0s7ok4uw	324	46	,	,	,
cord-001835-0s7ok4uw	324	47	4	4	CD
cord-001835-0s7ok4uw	324	48	)	)	-RRB-
cord-001835-0s7ok4uw	324	49	.	.	.
cord-001835-0s7ok4uw	325	1	This	this	DT
cord-001835-0s7ok4uw	325	2	fact	fact	NN
cord-001835-0s7ok4uw	325	3	confers	confer	VBZ
cord-001835-0s7ok4uw	325	4	to	to	IN
cord-001835-0s7ok4uw	325	5	Cpl-7	Cpl-7	NNP
cord-001835-0s7ok4uw	325	6	the	the	DT
cord-001835-0s7ok4uw	325	7	advantage	advantage	NN
cord-001835-0s7ok4uw	325	8	of	of	IN
cord-001835-0s7ok4uw	325	9	displaying	display	VBG
cord-001835-0s7ok4uw	325	10	a	a	DT
cord-001835-0s7ok4uw	325	11	broader	broad	JJR
cord-001835-0s7ok4uw	325	12	microbicide	microbicide	NN
cord-001835-0s7ok4uw	325	13	spectrum	spectrum	NN
cord-001835-0s7ok4uw	325	14	comparing	compare	VBG
cord-001835-0s7ok4uw	325	15	to	to	IN
cord-001835-0s7ok4uw	325	16	choline	choline	NN
cord-001835-0s7ok4uw	325	17	binding	bind	VBG
cord-001835-0s7ok4uw	325	18	proteins	protein	NNS
cord-001835-0s7ok4uw	325	19	(	(	-LRB-
cord-001835-0s7ok4uw	325	20	5	5	CD
cord-001835-0s7ok4uw	325	21	)	)	-RRB-
cord-001835-0s7ok4uw	325	22	.	.	.
cord-001835-0s7ok4uw	326	1	This	this	DT
cord-001835-0s7ok4uw	326	2	behavior	behavior	NN
cord-001835-0s7ok4uw	326	3	results	result	VBZ
cord-001835-0s7ok4uw	326	4	from	from	IN
cord-001835-0s7ok4uw	326	5	the	the	DT
cord-001835-0s7ok4uw	326	6	acquisition	acquisition	NN
cord-001835-0s7ok4uw	326	7	of	of	IN
cord-001835-0s7ok4uw	326	8	a	a	DT
cord-001835-0s7ok4uw	326	9	cell	cell	NN
cord-001835-0s7ok4uw	326	10	wall	wall	NN
cord-001835-0s7ok4uw	326	11	binding	bind	VBG
cord-001835-0s7ok4uw	326	12	module	module	NN
cord-001835-0s7ok4uw	326	13	(	(	-LRB-
cord-001835-0s7ok4uw	326	14	CWBM	CWBM	NNP
cord-001835-0s7ok4uw	326	15	)	)	-RRB-
cord-001835-0s7ok4uw	326	16	made	make	VBN
cord-001835-0s7ok4uw	326	17	of	of	IN
cord-001835-0s7ok4uw	326	18	three	three	CD
cord-001835-0s7ok4uw	326	19	identical	identical	JJ
cord-001835-0s7ok4uw	326	20	repeats	repeat	NNS
cord-001835-0s7ok4uw	326	21	of	of	IN
cord-001835-0s7ok4uw	326	22	48	48	CD
cord-001835-0s7ok4uw	326	23	amino	amino	NN
cord-001835-0s7ok4uw	326	24	acids	acid	NNS
cord-001835-0s7ok4uw	326	25	each	each	DT
cord-001835-0s7ok4uw	326	26	(	(	-LRB-
cord-001835-0s7ok4uw	326	27	CW_7	CW_7	NNP
cord-001835-0s7ok4uw	326	28	motifs	motif	NNS
cord-001835-0s7ok4uw	326	29	)	)	-RRB-
cord-001835-0s7ok4uw	326	30	,	,	,
cord-001835-0s7ok4uw	326	31	with	with	IN
cord-001835-0s7ok4uw	326	32	unknown	unknown	JJ
cord-001835-0s7ok4uw	326	33	specificity	specificity	NN
cord-001835-0s7ok4uw	326	34	and	and	CC
cord-001835-0s7ok4uw	326	35	totally	totally	RB
cord-001835-0s7ok4uw	326	36	unrelated	unrelated	JJ
cord-001835-0s7ok4uw	326	37	with	with	IN
cord-001835-0s7ok4uw	326	38	the	the	DT
cord-001835-0s7ok4uw	326	39	choline	choline	NN
cord-001835-0s7ok4uw	326	40	-	-	HYPH
cord-001835-0s7ok4uw	326	41	binding	bind	VBG
cord-001835-0s7ok4uw	326	42	motives	motive	NNS
cord-001835-0s7ok4uw	326	43	present	present	JJ
cord-001835-0s7ok4uw	326	44	in	in	IN
cord-001835-0s7ok4uw	326	45	pneumococcal	pneumococcal	JJ
cord-001835-0s7ok4uw	326	46	hydrolases	hydrolase	NNS
cord-001835-0s7ok4uw	326	47	.	.	.
cord-001835-0s7ok4uw	327	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	327	2	,	,	,
cord-001835-0s7ok4uw	327	3	CW_7	CW_7	NNP
cord-001835-0s7ok4uw	327	4	repeats	repeat	VBZ
cord-001835-0s7ok4uw	327	5	have	have	VBP
cord-001835-0s7ok4uw	327	6	been	be	VBN
cord-001835-0s7ok4uw	327	7	identified	identify	VBN
cord-001835-0s7ok4uw	327	8	in	in	IN
cord-001835-0s7ok4uw	327	9	many	many	JJ
cord-001835-0s7ok4uw	327	10	putative	putative	JJ
cord-001835-0s7ok4uw	327	11	proteins	protein	NNS
cord-001835-0s7ok4uw	327	12	potentially	potentially	RB
cord-001835-0s7ok4uw	327	13	involved	involve	VBN
cord-001835-0s7ok4uw	327	14	in	in	IN
cord-001835-0s7ok4uw	327	15	cell	cell	NN
cord-001835-0s7ok4uw	327	16	wall	wall	NN
cord-001835-0s7ok4uw	327	17	metabolism	metabolism	NN
cord-001835-0s7ok4uw	328	1	(	(	-LRB-
cord-001835-0s7ok4uw	328	2	Pfam	Pfam	NNP
cord-001835-0s7ok4uw	328	3	entry	entry	NN
cord-001835-0s7ok4uw	328	4	:	:	:
cord-001835-0s7ok4uw	328	5	PF08230	pf08230	LS
cord-001835-0s7ok4uw	328	6	)	)	-RRB-
cord-001835-0s7ok4uw	328	7	from	from	IN
cord-001835-0s7ok4uw	328	8	different	different	JJ
cord-001835-0s7ok4uw	328	9	species	specie	NNS
cord-001835-0s7ok4uw	328	10	of	of	IN
cord-001835-0s7ok4uw	328	11	Gram	gram	NN
cord-001835-0s7ok4uw	328	12	positive	positive	JJ
cord-001835-0s7ok4uw	328	13	and	and	CC
cord-001835-0s7ok4uw	328	14	Gram	Gram	NNP
cord-001835-0s7ok4uw	328	15	negative	negative	JJ
cord-001835-0s7ok4uw	328	16	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	328	17	,	,	,
cord-001835-0s7ok4uw	328	18	and	and	CC
cord-001835-0s7ok4uw	328	19	some	some	DT
cord-001835-0s7ok4uw	328	20	bacteriophages	bacteriophage	NNS
cord-001835-0s7ok4uw	328	21	(	(	-LRB-
cord-001835-0s7ok4uw	328	22	6	6	CD
cord-001835-0s7ok4uw	328	23	)	)	-RRB-
cord-001835-0s7ok4uw	328	24	.	.	.
cord-001835-0s7ok4uw	329	1	Preliminary	preliminary	JJ
cord-001835-0s7ok4uw	329	2	studies	study	NNS
cord-001835-0s7ok4uw	329	3	of	of	IN
cord-001835-0s7ok4uw	329	4	thermal	thermal	JJ
cord-001835-0s7ok4uw	329	5	stability	stability	NN
cord-001835-0s7ok4uw	329	6	in	in	IN
cord-001835-0s7ok4uw	329	7	presence	presence	NN
cord-001835-0s7ok4uw	329	8	of	of	IN
cord-001835-0s7ok4uw	329	9	a	a	DT
cord-001835-0s7ok4uw	329	10	small	small	JJ
cord-001835-0s7ok4uw	329	11	cell	cell	NN
cord-001835-0s7ok4uw	329	12	wall	wall	NN
cord-001835-0s7ok4uw	329	13	structural	structural	JJ
cord-001835-0s7ok4uw	329	14	-	-	HYPH
cord-001835-0s7ok4uw	329	15	analogue	analogue	NN
cord-001835-0s7ok4uw	329	16	(	(	-LRB-
cord-001835-0s7ok4uw	329	17	GlcNAc	GlcNAc	NNP
cord-001835-0s7ok4uw	329	18	-	-	HYPH
cord-001835-0s7ok4uw	329	19	MurNAc	MurNAc	NNP
cord-001835-0s7ok4uw	329	20	-	-	HYPH
cord-001835-0s7ok4uw	329	21	L	L	NNP
cord-001835-0s7ok4uw	329	22	-	-	HYPH
cord-001835-0s7ok4uw	329	23	Ala	Ala	NNP
cord-001835-0s7ok4uw	329	24	-	-	HYPH
cord-001835-0s7ok4uw	329	25	D	D	NNP
cord-001835-0s7ok4uw	329	26	-	-	HYPH
cord-001835-0s7ok4uw	329	27	IsoGln	IsoGln	NNP
cord-001835-0s7ok4uw	329	28	)	)	-RRB-
cord-001835-0s7ok4uw	329	29	point	point	NN
cord-001835-0s7ok4uw	329	30	to	to	IN
cord-001835-0s7ok4uw	329	31	the	the	DT
cord-001835-0s7ok4uw	329	32	muropeptide	muropeptide	NN
cord-001835-0s7ok4uw	329	33	as	as	IN
cord-001835-0s7ok4uw	329	34	the	the	DT
cord-001835-0s7ok4uw	329	35	cell	cell	NN
cord-001835-0s7ok4uw	329	36	wall	wall	NN
cord-001835-0s7ok4uw	329	37	target	target	NN
cord-001835-0s7ok4uw	329	38	recognized	recognize	VBN
cord-001835-0s7ok4uw	329	39	by	by	IN
cord-001835-0s7ok4uw	329	40	CW_7	CW_7	NNS
cord-001835-0s7ok4uw	329	41	motifs	motifs	NNP
cord-001835-0s7ok4uw	329	42	(	(	-LRB-
cord-001835-0s7ok4uw	329	43	7	7	CD
cord-001835-0s7ok4uw	329	44	)	)	-RRB-
cord-001835-0s7ok4uw	329	45	.	.	.
cord-001835-0s7ok4uw	330	1	In	in	IN
cord-001835-0s7ok4uw	330	2	this	this	DT
cord-001835-0s7ok4uw	330	3	communication	communication	NN
cord-001835-0s7ok4uw	330	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	330	5	have	have	VBP
cord-001835-0s7ok4uw	330	6	gone	go	VBN
cord-001835-0s7ok4uw	330	7	in	in	IN
cord-001835-0s7ok4uw	330	8	depth	depth	NN
cord-001835-0s7ok4uw	330	9	in	in	IN
cord-001835-0s7ok4uw	330	10	the	the	DT
cord-001835-0s7ok4uw	330	11	characterization	characterization	NN
cord-001835-0s7ok4uw	330	12	of	of	IN
cord-001835-0s7ok4uw	330	13	CW_7	CW_7	NNP
cord-001835-0s7ok4uw	330	14	repeats	repeat	VBZ
cord-001835-0s7ok4uw	330	15	.	.	.
cord-001835-0s7ok4uw	331	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	331	2	present	present	VBP
cord-001835-0s7ok4uw	331	3	the	the	DT
cord-001835-0s7ok4uw	331	4	first	first	JJ
cord-001835-0s7ok4uw	331	5	crystal	crystal	NN
cord-001835-0s7ok4uw	331	6	structure	structure	NN
cord-001835-0s7ok4uw	331	7	of	of	IN
cord-001835-0s7ok4uw	331	8	the	the	DT
cord-001835-0s7ok4uw	331	9	CW_7	CW_7	NNP
cord-001835-0s7ok4uw	331	10	motif	motif	NN
cord-001835-0s7ok4uw	331	11	,	,	,
cord-001835-0s7ok4uw	331	12	which	which	WDT
cord-001835-0s7ok4uw	331	13	reveals	reveal	VBZ
cord-001835-0s7ok4uw	331	14	a	a	DT
cord-001835-0s7ok4uw	331	15	three	three	CD
cord-001835-0s7ok4uw	331	16	-	-	HYPH
cord-001835-0s7ok4uw	331	17	helical	helical	NN
cord-001835-0s7ok4uw	331	18	bundle	bundle	NN
cord-001835-0s7ok4uw	331	19	folding	folding	NN
cord-001835-0s7ok4uw	331	20	.	.	.
cord-001835-0s7ok4uw	332	1	Using	use	VBG
cord-001835-0s7ok4uw	332	2	STD_NMR	std_nmr	NN
cord-001835-0s7ok4uw	332	3	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	332	4	the	the	DT
cord-001835-0s7ok4uw	332	5	epitope	epitope	NN
cord-001835-0s7ok4uw	332	6	of	of	IN
cord-001835-0s7ok4uw	332	7	binding	binding	NN
cord-001835-0s7ok4uw	332	8	of	of	IN
cord-001835-0s7ok4uw	332	9	the	the	DT
cord-001835-0s7ok4uw	332	10	disacharide	disacharide	NN
cord-001835-0s7ok4uw	332	11	dipeptide	dipeptide	JJ
cord-001835-0s7ok4uw	332	12	to	to	IN
cord-001835-0s7ok4uw	332	13	this	this	DT
cord-001835-0s7ok4uw	332	14	repeats	repeat	VBZ
cord-001835-0s7ok4uw	332	15	has	have	VBZ
cord-001835-0s7ok4uw	332	16	been	be	VBN
cord-001835-0s7ok4uw	332	17	identified	identify	VBN
cord-001835-0s7ok4uw	332	18	.	.	.
cord-001835-0s7ok4uw	333	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	333	2	,	,	,
cord-001835-0s7ok4uw	333	3	the	the	DT
cord-001835-0s7ok4uw	333	4	b	b	NNP
cord-001835-0s7ok4uw	333	5	anomer	anomer	NNP
cord-001835-0s7ok4uw	333	6	of	of	IN
cord-001835-0s7ok4uw	333	7	the	the	DT
cord-001835-0s7ok4uw	333	8	MurNAc	MurNAc	NNP
cord-001835-0s7ok4uw	333	9	moiety	moiety	NN
cord-001835-0s7ok4uw	333	10	,	,	,
cord-001835-0s7ok4uw	333	11	the	the	DT
cord-001835-0s7ok4uw	333	12	form	form	NN
cord-001835-0s7ok4uw	333	13	present	present	JJ
cord-001835-0s7ok4uw	333	14	in	in	IN
cord-001835-0s7ok4uw	333	15	the	the	DT
cord-001835-0s7ok4uw	333	16	peptidoglycan	peptidoglycan	NN
cord-001835-0s7ok4uw	333	17	,	,	,
cord-001835-0s7ok4uw	333	18	seems	seem	VBZ
cord-001835-0s7ok4uw	333	19	to	to	TO
cord-001835-0s7ok4uw	333	20	be	be	VB
cord-001835-0s7ok4uw	333	21	preferentially	preferentially	RB
cord-001835-0s7ok4uw	333	22	recognized	recognize	VBN
cord-001835-0s7ok4uw	333	23	with	with	IN
cord-001835-0s7ok4uw	333	24	respect	respect	NN
cord-001835-0s7ok4uw	333	25	to	to	IN
cord-001835-0s7ok4uw	333	26	the	the	DT
cord-001835-0s7ok4uw	333	27	a	a	DT
cord-001835-0s7ok4uw	333	28	anomer	anomer	NN
cord-001835-0s7ok4uw	333	29	.	.	.
cord-001835-0s7ok4uw	334	1	Finally	finally	RB
cord-001835-0s7ok4uw	334	2	,	,	,
cord-001835-0s7ok4uw	334	3	a	a	DT
cord-001835-0s7ok4uw	334	4	docking	docking	NN
cord-001835-0s7ok4uw	334	5	model	model	NN
cord-001835-0s7ok4uw	334	6	of	of	IN
cord-001835-0s7ok4uw	334	7	the	the	DT
cord-001835-0s7ok4uw	334	8	complex	complex	JJ
cord-001835-0s7ok4uw	334	9	CW_7	CW_7	NNS
cord-001835-0s7ok4uw	334	10	/	/	SYM
cord-001835-0s7ok4uw	334	11	GMDP	GMDP	NNP
cord-001835-0s7ok4uw	334	12	compatible	compatible	JJ
cord-001835-0s7ok4uw	334	13	with	with	IN
cord-001835-0s7ok4uw	334	14	STD	STD	NNP
cord-001835-0s7ok4uw	334	15	results	result	NNS
cord-001835-0s7ok4uw	334	16	was	be	VBD
cord-001835-0s7ok4uw	334	17	built	build	VBN
cord-001835-0s7ok4uw	334	18	allowing	allow	VBG
cord-001835-0s7ok4uw	334	19	to	to	TO
cord-001835-0s7ok4uw	334	20	identify	identify	VB
cord-001835-0s7ok4uw	334	21	the	the	DT
cord-001835-0s7ok4uw	334	22	major	major	JJ
cord-001835-0s7ok4uw	334	23	contacts	contact	NNS
cord-001835-0s7ok4uw	334	24	between	between	IN
cord-001835-0s7ok4uw	334	25	the	the	DT
cord-001835-0s7ok4uw	334	26	protein	protein	NN
cord-001835-0s7ok4uw	334	27	and	and	CC
cord-001835-0s7ok4uw	334	28	the	the	DT
cord-001835-0s7ok4uw	334	29	muropeptide	muropeptide	NN
cord-001835-0s7ok4uw	334	30	and	and	CC
cord-001835-0s7ok4uw	334	31	to	to	TO
cord-001835-0s7ok4uw	334	32	propose	propose	VB
cord-001835-0s7ok4uw	334	33	the	the	DT
cord-001835-0s7ok4uw	334	34	relevant	relevant	JJ
cord-001835-0s7ok4uw	334	35	role	role	NN
cord-001835-0s7ok4uw	334	36	of	of	IN
cord-001835-0s7ok4uw	334	37	a	a	DT
cord-001835-0s7ok4uw	334	38	conserved	conserve	VBN
cord-001835-0s7ok4uw	334	39	Arginine	arginine	NN
cord-001835-0s7ok4uw	334	40	residue	residue	NN
cord-001835-0s7ok4uw	334	41	in	in	IN
cord-001835-0s7ok4uw	334	42	this	this	DT
cord-001835-0s7ok4uw	334	43	interaction	interaction	NN
cord-001835-0s7ok4uw	334	44	.	.	.
cord-001835-0s7ok4uw	335	1	1	1	LS
cord-001835-0s7ok4uw	335	2	Energy	energy	NN
cord-001835-0s7ok4uw	335	3	-	-	HYPH
cord-001835-0s7ok4uw	335	4	dependent	dependent	JJ
cord-001835-0s7ok4uw	335	5	AAA1	AAA1	NNP
cord-001835-0s7ok4uw	335	6	proteases	protease	NNS
cord-001835-0s7ok4uw	335	7	carry	carry	VBP
cord-001835-0s7ok4uw	335	8	out	out	RP
cord-001835-0s7ok4uw	335	9	regulated	regulate	VBN
cord-001835-0s7ok4uw	335	10	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	335	11	to	to	TO
cord-001835-0s7ok4uw	335	12	ensure	ensure	VB
cord-001835-0s7ok4uw	335	13	protein	protein	NN
cord-001835-0s7ok4uw	335	14	quality	quality	NN
cord-001835-0s7ok4uw	335	15	control	control	NN
cord-001835-0s7ok4uw	335	16	and	and	CC
cord-001835-0s7ok4uw	335	17	post	post	JJ
cord-001835-0s7ok4uw	335	18	-	-	JJ
cord-001835-0s7ok4uw	335	19	translational	translational	JJ
cord-001835-0s7ok4uw	335	20	regulation	regulation	NN
cord-001835-0s7ok4uw	335	21	of	of	IN
cord-001835-0s7ok4uw	335	22	many	many	JJ
cord-001835-0s7ok4uw	335	23	cellular	cellular	JJ
cord-001835-0s7ok4uw	335	24	processes	process	NNS
cord-001835-0s7ok4uw	335	25	.	.	.
cord-001835-0s7ok4uw	336	1	Control	control	NN
cord-001835-0s7ok4uw	336	2	of	of	IN
cord-001835-0s7ok4uw	336	3	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	336	4	occurs	occur	VBZ
cord-001835-0s7ok4uw	336	5	primarily	primarily	RB
cord-001835-0s7ok4uw	336	6	at	at	IN
cord-001835-0s7ok4uw	336	7	the	the	DT
cord-001835-0s7ok4uw	336	8	level	level	NN
cord-001835-0s7ok4uw	336	9	of	of	IN
cord-001835-0s7ok4uw	336	10	substrate	substrate	NN
cord-001835-0s7ok4uw	336	11	recognition	recognition	NN
cord-001835-0s7ok4uw	336	12	,	,	,
cord-001835-0s7ok4uw	336	13	which	which	WDT
cord-001835-0s7ok4uw	336	14	can	can	MD
cord-001835-0s7ok4uw	336	15	be	be	VB
cord-001835-0s7ok4uw	336	16	modulated	modulate	VBN
cord-001835-0s7ok4uw	336	17	by	by	IN
cord-001835-0s7ok4uw	336	18	adaptor	adaptor	NN
cord-001835-0s7ok4uw	336	19	proteins	protein	NNS
cord-001835-0s7ok4uw	336	20	.	.	.
cord-001835-0s7ok4uw	337	1	The	the	DT
cord-001835-0s7ok4uw	337	2	ClpS	ClpS	NNP
cord-001835-0s7ok4uw	337	3	adaptor	adaptor	NN
cord-001835-0s7ok4uw	337	4	protein	protein	NN
cord-001835-0s7ok4uw	337	5	enhances	enhance	VBZ
cord-001835-0s7ok4uw	337	6	and	and	CC
cord-001835-0s7ok4uw	337	7	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	337	8	degradation	degradation	NN
cord-001835-0s7ok4uw	337	9	of	of	IN
cord-001835-0s7ok4uw	337	10	different	different	JJ
cord-001835-0s7ok4uw	337	11	classes	class	NNS
cord-001835-0s7ok4uw	337	12	of	of	IN
cord-001835-0s7ok4uw	337	13	substrates	substrate	NNS
cord-001835-0s7ok4uw	337	14	,	,	,
cord-001835-0s7ok4uw	337	15	and	and	CC
cord-001835-0s7ok4uw	337	16	thus	thus	RB
cord-001835-0s7ok4uw	337	17	triggers	trigger	VBZ
cord-001835-0s7ok4uw	337	18	a	a	DT
cord-001835-0s7ok4uw	337	19	specificity	specificity	NN
cord-001835-0s7ok4uw	337	20	switch	switch	NN
cord-001835-0s7ok4uw	337	21	in	in	IN
cord-001835-0s7ok4uw	337	22	ClpA.	ClpA.	NNP
cord-001835-0s7ok4uw	338	1	Whereas	whereas	IN
cord-001835-0s7ok4uw	338	2	the	the	DT
cord-001835-0s7ok4uw	338	3	mechanism	mechanism	NN
cord-001835-0s7ok4uw	338	4	for	for	IN
cord-001835-0s7ok4uw	338	5	substrate	substrate	JJ
cord-001835-0s7ok4uw	338	6	delivery	delivery	NN
cord-001835-0s7ok4uw	338	7	by	by	IN
cord-001835-0s7ok4uw	338	8	ClpS	ClpS	NNP
cord-001835-0s7ok4uw	338	9	has	have	VBZ
cord-001835-0s7ok4uw	338	10	been	be	VBN
cord-001835-0s7ok4uw	338	11	described	describe	VBN
cord-001835-0s7ok4uw	338	12	in	in	IN
cord-001835-0s7ok4uw	338	13	detail	detail	NN
cord-001835-0s7ok4uw	338	14	,	,	,
cord-001835-0s7ok4uw	338	15	the	the	DT
cord-001835-0s7ok4uw	338	16	inhibition	inhibition	NN
cord-001835-0s7ok4uw	338	17	mechanism	mechanism	NN
cord-001835-0s7ok4uw	338	18	is	be	VBZ
cord-001835-0s7ok4uw	338	19	poorly	poorly	RB
cord-001835-0s7ok4uw	338	20	understood	understand	VBN
cord-001835-0s7ok4uw	338	21	.	.	.
cord-001835-0s7ok4uw	339	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	339	2	show	show	VBP
cord-001835-0s7ok4uw	339	3	that	that	IN
cord-001835-0s7ok4uw	339	4	ClpS	ClpS	NNP
cord-001835-0s7ok4uw	339	5	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	339	6	ssrA	ssrA	,
cord-001835-0s7ok4uw	339	7	substrate	substrate	NN
cord-001835-0s7ok4uw	339	8	recognition	recognition	NN
cord-001835-0s7ok4uw	339	9	and	and	CC
cord-001835-0s7ok4uw	339	10	processing	processing	NN
cord-001835-0s7ok4uw	339	11	,	,	,
cord-001835-0s7ok4uw	339	12	instead	instead	RB
cord-001835-0s7ok4uw	339	13	of	of	IN
cord-001835-0s7ok4uw	339	14	simply	simply	RB
cord-001835-0s7ok4uw	339	15	preventing	prevent	VBG
cord-001835-0s7ok4uw	339	16	substrate	substrate	NN
cord-001835-0s7ok4uw	339	17	binding	bind	VBG
cord-001835-0s7ok4uw	339	18	.	.	.
cord-001835-0s7ok4uw	340	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	340	2	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	340	3	that	that	IN
cord-001835-0s7ok4uw	340	4	ClpA	ClpA	NNP
cord-001835-0s7ok4uw	340	5	engagement	engagement	NN
cord-001835-0s7ok4uw	340	6	of	of	IN
cord-001835-0s7ok4uw	340	7	the	the	DT
cord-001835-0s7ok4uw	340	8	ClpS	ClpS	NNP
cord-001835-0s7ok4uw	340	9	N	N	NNP
cord-001835-0s7ok4uw	340	10	-	-	HYPH
cord-001835-0s7ok4uw	340	11	terminal	terminal	NN
cord-001835-0s7ok4uw	340	12	extension	extension	NN
cord-001835-0s7ok4uw	340	13	(	(	-LRB-
cord-001835-0s7ok4uw	340	14	NTE	NTE	NNP
cord-001835-0s7ok4uw	340	15	)	)	-RRB-
cord-001835-0s7ok4uw	340	16	is	be	VBZ
cord-001835-0s7ok4uw	340	17	necessary	necessary	JJ
cord-001835-0s7ok4uw	340	18	,	,	,
cord-001835-0s7ok4uw	340	19	and	and	CC
cord-001835-0s7ok4uw	340	20	may	may	MD
cord-001835-0s7ok4uw	340	21	even	even	RB
cord-001835-0s7ok4uw	340	22	be	be	VB
cord-001835-0s7ok4uw	340	23	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	340	24	,	,	,
cord-001835-0s7ok4uw	340	25	for	for	IN
cord-001835-0s7ok4uw	340	26	inhibition	inhibition	NN
cord-001835-0s7ok4uw	340	27	.	.	.
cord-001835-0s7ok4uw	341	1	In	in	IN
cord-001835-0s7ok4uw	341	2	addition	addition	NN
cord-001835-0s7ok4uw	341	3	,	,	,
cord-001835-0s7ok4uw	341	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	341	5	find	find	VBP
cord-001835-0s7ok4uw	341	6	that	that	IN
cord-001835-0s7ok4uw	341	7	inhibition	inhibition	NN
cord-001835-0s7ok4uw	341	8	of	of	IN
cord-001835-0s7ok4uw	341	9	substrate	substrate	JJ
cord-001835-0s7ok4uw	341	10	processing	processing	NN
cord-001835-0s7ok4uw	341	11	requires	require	VBZ
cord-001835-0s7ok4uw	341	12	a	a	DT
cord-001835-0s7ok4uw	341	13	longer	long	JJR
cord-001835-0s7ok4uw	341	14	NTE	NTE	NNP
cord-001835-0s7ok4uw	341	15	,	,	,
cord-001835-0s7ok4uw	341	16	as	as	IN
cord-001835-0s7ok4uw	341	17	compared	compare	VBN
cord-001835-0s7ok4uw	341	18	to	to	IN
cord-001835-0s7ok4uw	341	19	inhibition	inhibition	NN
cord-001835-0s7ok4uw	341	20	of	of	IN
cord-001835-0s7ok4uw	341	21	substrate	substrate	JJ
cord-001835-0s7ok4uw	341	22	recognition	recognition	NN
cord-001835-0s7ok4uw	341	23	.	.	.
cord-001835-0s7ok4uw	342	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	342	2	,	,	,
cord-001835-0s7ok4uw	342	3	the	the	DT
cord-001835-0s7ok4uw	342	4	NTE	NTE	NNP
cord-001835-0s7ok4uw	342	5	length	length	NN
cord-001835-0s7ok4uw	342	6	required	require	VBN
cord-001835-0s7ok4uw	342	7	for	for	IN
cord-001835-0s7ok4uw	342	8	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	342	9	substrate	substrate	NN
cord-001835-0s7ok4uw	342	10	processing	processing	NN
cord-001835-0s7ok4uw	342	11	is	be	VBZ
cord-001835-0s7ok4uw	342	12	also	also	RB
cord-001835-0s7ok4uw	342	13	necessary	necessary	JJ
cord-001835-0s7ok4uw	342	14	for	for	IN
cord-001835-0s7ok4uw	342	15	suppression	suppression	NN
cord-001835-0s7ok4uw	342	16	of	of	IN
cord-001835-0s7ok4uw	342	17	the	the	DT
cord-001835-0s7ok4uw	342	18	ClpA	ClpA	NNP
cord-001835-0s7ok4uw	342	19	ATPase	ATPase	NNP
cord-001835-0s7ok4uw	342	20	rate	rate	NN
cord-001835-0s7ok4uw	342	21	.	.	.
cord-001835-0s7ok4uw	343	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	343	2	,	,	,
cord-001835-0s7ok4uw	343	3	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	343	4	data	data	NN
cord-001835-0s7ok4uw	343	5	suggests	suggest	VBZ
cord-001835-0s7ok4uw	343	6	that	that	IN
cord-001835-0s7ok4uw	343	7	ClpS	ClpS	NNP
cord-001835-0s7ok4uw	343	8	slows	slow	VBZ
cord-001835-0s7ok4uw	343	9	down	down	RP
cord-001835-0s7ok4uw	343	10	substrate	substrate	NN
cord-001835-0s7ok4uw	343	11	translocation	translocation	NN
cord-001835-0s7ok4uw	343	12	.	.	.
cord-001835-0s7ok4uw	344	1	These	these	DT
cord-001835-0s7ok4uw	344	2	results	result	NNS
cord-001835-0s7ok4uw	344	3	support	support	VBP
cord-001835-0s7ok4uw	344	4	a	a	DT
cord-001835-0s7ok4uw	344	5	model	model	NN
cord-001835-0s7ok4uw	344	6	where	where	WRB
cord-001835-0s7ok4uw	344	7	there	there	EX
cord-001835-0s7ok4uw	344	8	is	be	VBZ
cord-001835-0s7ok4uw	344	9	an	an	DT
cord-001835-0s7ok4uw	344	10	ssrA•ClpA•ClpS	ssra•clpa•clps	CD
cord-001835-0s7ok4uw	344	11	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	344	12	complex	complex	NN
cord-001835-0s7ok4uw	344	13	in	in	IN
cord-001835-0s7ok4uw	344	14	which	which	WDT
cord-001835-0s7ok4uw	344	15	the	the	DT
cord-001835-0s7ok4uw	344	16	ClpA	ClpA	NNP
cord-001835-0s7ok4uw	344	17	pore	pore	NN
cord-001835-0s7ok4uw	344	18	engages	engage	VBZ
cord-001835-0s7ok4uw	344	19	the	the	DT
cord-001835-0s7ok4uw	344	20	ClpS	ClpS	NNP
cord-001835-0s7ok4uw	344	21	NTE	NTE	NNP
cord-001835-0s7ok4uw	344	22	.	.	.
cord-001835-0s7ok4uw	345	1	This	this	DT
cord-001835-0s7ok4uw	345	2	engagement	engagement	NN
cord-001835-0s7ok4uw	345	3	of	of	IN
cord-001835-0s7ok4uw	345	4	the	the	DT
cord-001835-0s7ok4uw	345	5	NTE	NTE	NNP
cord-001835-0s7ok4uw	345	6	causes	cause	VBZ
cord-001835-0s7ok4uw	345	7	suppression	suppression	NN
cord-001835-0s7ok4uw	345	8	of	of	IN
cord-001835-0s7ok4uw	345	9	ATPase	ATPase	NNP
cord-001835-0s7ok4uw	345	10	activity	activity	NN
cord-001835-0s7ok4uw	345	11	,	,	,
cord-001835-0s7ok4uw	345	12	and	and	CC
cord-001835-0s7ok4uw	345	13	therefore	therefore	RB
cord-001835-0s7ok4uw	345	14	slower	slow	JJR
cord-001835-0s7ok4uw	345	15	substrate	substrate	NN
cord-001835-0s7ok4uw	345	16	translocation	translocation	NN
cord-001835-0s7ok4uw	345	17	and	and	CC
cord-001835-0s7ok4uw	345	18	processing	processing	NN
cord-001835-0s7ok4uw	345	19	.	.	.
cord-001835-0s7ok4uw	346	1	This	this	DT
cord-001835-0s7ok4uw	346	2	model	model	NN
cord-001835-0s7ok4uw	346	3	illustrates	illustrate	VBZ
cord-001835-0s7ok4uw	346	4	how	how	WRB
cord-001835-0s7ok4uw	346	5	an	an	DT
cord-001835-0s7ok4uw	346	6	adaptor	adaptor	NN
cord-001835-0s7ok4uw	346	7	protein	protein	NN
cord-001835-0s7ok4uw	346	8	can	can	MD
cord-001835-0s7ok4uw	346	9	inhibit	inhibit	VB
cord-001835-0s7ok4uw	346	10	recognition	recognition	NN
cord-001835-0s7ok4uw	346	11	of	of	IN
cord-001835-0s7ok4uw	346	12	one	one	CD
cord-001835-0s7ok4uw	346	13	type	type	NN
cord-001835-0s7ok4uw	346	14	of	of	IN
cord-001835-0s7ok4uw	346	15	substrate	substrate	NN
cord-001835-0s7ok4uw	346	16	while	while	IN
cord-001835-0s7ok4uw	346	17	efficiently	efficiently	RB
cord-001835-0s7ok4uw	346	18	promoting	promote	VBG
cord-001835-0s7ok4uw	346	19	degradation	degradation	NN
cord-001835-0s7ok4uw	346	20	of	of	IN
cord-001835-0s7ok4uw	346	21	a	a	DT
cord-001835-0s7ok4uw	346	22	different	different	JJ
cord-001835-0s7ok4uw	346	23	substrate	substrate	NN
cord-001835-0s7ok4uw	346	24	.	.	.
cord-001835-0s7ok4uw	347	1	Single	single	JJ
cord-001835-0s7ok4uw	347	2	-	-	HYPH
cord-001835-0s7ok4uw	347	3	molecule	molecule	NN
cord-001835-0s7ok4uw	347	4	assay	assay	NN
cord-001835-0s7ok4uw	347	5	development	development	NN
cord-001835-0s7ok4uw	347	6	for	for	IN
cord-001835-0s7ok4uw	347	7	studying	study	VBG
cord-001835-0s7ok4uw	347	8	Human	Human	NNP
cord-001835-0s7ok4uw	347	9	RNA	RNA	NNP
cord-001835-0s7ok4uw	347	10	Polymerase	Polymerase	NNP
cord-001835-0s7ok4uw	347	11	II	II	NNP
cord-001835-0s7ok4uw	347	12	Promoter	Promoter	NNP
cord-001835-0s7ok4uw	347	13	-	-	HYPH
cord-001835-0s7ok4uw	347	14	Proximal	Proximal	NNP
cord-001835-0s7ok4uw	347	15	Pausing	Pausing	NNP
cord-001835-0s7ok4uw	347	16	RNA	RNA	NNP
cord-001835-0s7ok4uw	347	17	Polymerase	Polymerase	NNP
cord-001835-0s7ok4uw	347	18	II	II	NNP
cord-001835-0s7ok4uw	347	19	(	(	-LRB-
cord-001835-0s7ok4uw	347	20	PolII	polii	NN
cord-001835-0s7ok4uw	347	21	)	)	-RRB-
cord-001835-0s7ok4uw	347	22	pausing	pausing	NN
cord-001835-0s7ok4uw	347	23	has	have	VBZ
cord-001835-0s7ok4uw	347	24	been	be	VBN
cord-001835-0s7ok4uw	347	25	shown	show	VBN
cord-001835-0s7ok4uw	347	26	to	to	TO
cord-001835-0s7ok4uw	347	27	play	play	VB
cord-001835-0s7ok4uw	347	28	a	a	DT
cord-001835-0s7ok4uw	347	29	significant	significant	JJ
cord-001835-0s7ok4uw	347	30	role	role	NN
cord-001835-0s7ok4uw	347	31	in	in	IN
cord-001835-0s7ok4uw	347	32	transcription	transcription	NN
cord-001835-0s7ok4uw	347	33	regulation	regulation	NN
cord-001835-0s7ok4uw	347	34	of	of	IN
cord-001835-0s7ok4uw	347	35	elongating	elongate	VBG
cord-001835-0s7ok4uw	347	36	PolII	polii	NN
cord-001835-0s7ok4uw	347	37	complexes	complex	NNS
cord-001835-0s7ok4uw	347	38	in	in	IN
cord-001835-0s7ok4uw	347	39	a	a	DT
cord-001835-0s7ok4uw	347	40	large	large	JJ
cord-001835-0s7ok4uw	347	41	number	number	NN
cord-001835-0s7ok4uw	347	42	of	of	IN
cord-001835-0s7ok4uw	347	43	metazoan	metazoan	NN
cord-001835-0s7ok4uw	347	44	and	and	CC
cord-001835-0s7ok4uw	347	45	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	347	46	genes	gene	NNS
cord-001835-0s7ok4uw	347	47	(	(	-LRB-
cord-001835-0s7ok4uw	347	48	1	1	CD
cord-001835-0s7ok4uw	347	49	)	)	-RRB-
cord-001835-0s7ok4uw	347	50	.	.	.
cord-001835-0s7ok4uw	348	1	The	the	DT
cord-001835-0s7ok4uw	348	2	traditional	traditional	JJ
cord-001835-0s7ok4uw	348	3	understanding	understanding	NN
cord-001835-0s7ok4uw	348	4	of	of	IN
cord-001835-0s7ok4uw	348	5	transcription	transcription	NN
cord-001835-0s7ok4uw	348	6	regulation	regulation	NN
cord-001835-0s7ok4uw	348	7	in	in	IN
cord-001835-0s7ok4uw	348	8	mammals	mammal	NNS
cord-001835-0s7ok4uw	348	9	involved	involve	VBN
cord-001835-0s7ok4uw	348	10	controlling	control	VBG
cord-001835-0s7ok4uw	348	11	PolII	polii	NN
cord-001835-0s7ok4uw	348	12	recruitment	recruitment	NN
cord-001835-0s7ok4uw	348	13	to	to	IN
cord-001835-0s7ok4uw	348	14	promoters	promoter	NNS
cord-001835-0s7ok4uw	348	15	and	and	CC
cord-001835-0s7ok4uw	348	16	controlling	control	VBG
cord-001835-0s7ok4uw	348	17	initial	initial	JJ
cord-001835-0s7ok4uw	348	18	steps	step	NNS
cord-001835-0s7ok4uw	348	19	at	at	IN
cord-001835-0s7ok4uw	348	20	the	the	DT
cord-001835-0s7ok4uw	348	21	promoter	promoter	NN
cord-001835-0s7ok4uw	348	22	,	,	,
cord-001835-0s7ok4uw	348	23	including	include	VBG
cord-001835-0s7ok4uw	348	24	pre	pre	JJ
cord-001835-0s7ok4uw	348	25	-	-	JJ
cord-001835-0s7ok4uw	348	26	initiation	initiation	JJ
cord-001835-0s7ok4uw	348	27	complex	complex	JJ
cord-001835-0s7ok4uw	348	28	formation	formation	NN
cord-001835-0s7ok4uw	348	29	and	and	CC
cord-001835-0s7ok4uw	348	30	promoter	promoter	NN
cord-001835-0s7ok4uw	348	31	escape	escape	NN
cord-001835-0s7ok4uw	348	32	.	.	.
cord-001835-0s7ok4uw	349	1	Most	Most	JJS
cord-001835-0s7ok4uw	349	2	works	work	VBZ
cord-001835-0s7ok4uw	349	3	investigating	investigate	VBG
cord-001835-0s7ok4uw	349	4	promoter	promoter	NN
cord-001835-0s7ok4uw	349	5	-	-	HYPH
cord-001835-0s7ok4uw	349	6	proximal	proximal	JJ
cord-001835-0s7ok4uw	349	7	PolII	PolII	NNP
cord-001835-0s7ok4uw	349	8	pausing	pause	VBG
cord-001835-0s7ok4uw	349	9	have	have	VBP
cord-001835-0s7ok4uw	349	10	employed	employ	VBN
cord-001835-0s7ok4uw	349	11	chromatin	chromatin	NN
cord-001835-0s7ok4uw	349	12	immunoprecipitation	immunoprecipitation	NN
cord-001835-0s7ok4uw	349	13	followed	follow	VBN
cord-001835-0s7ok4uw	349	14	by	by	IN
cord-001835-0s7ok4uw	349	15	sequencing	sequence	VBG
cord-001835-0s7ok4uw	349	16	to	to	TO
cord-001835-0s7ok4uw	349	17	determine	determine	VB
cord-001835-0s7ok4uw	349	18	PolII	polii	NN
cord-001835-0s7ok4uw	349	19	localization	localization	NN
cord-001835-0s7ok4uw	349	20	or	or	CC
cord-001835-0s7ok4uw	349	21	in	in	IN
cord-001835-0s7ok4uw	349	22	vitro	vitro	FW
cord-001835-0s7ok4uw	349	23	transcriptional	transcriptional	JJ
cord-001835-0s7ok4uw	349	24	assays	assay	NNS
cord-001835-0s7ok4uw	349	25	using	use	VBG
cord-001835-0s7ok4uw	349	26	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	349	27	extracts	extract	NNS
cord-001835-0s7ok4uw	349	28	analyzed	analyze	VBN
cord-001835-0s7ok4uw	349	29	with	with	IN
cord-001835-0s7ok4uw	349	30	radio	radio	NN
cord-001835-0s7ok4uw	349	31	-	-	HYPH
cord-001835-0s7ok4uw	349	32	active	active	JJ
cord-001835-0s7ok4uw	349	33	gel	gel	NN
cord-001835-0s7ok4uw	349	34	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	349	35	.	.	.
cord-001835-0s7ok4uw	350	1	In	in	IN
cord-001835-0s7ok4uw	350	2	order	order	NN
cord-001835-0s7ok4uw	350	3	to	to	TO
cord-001835-0s7ok4uw	350	4	gain	gain	VB
cord-001835-0s7ok4uw	350	5	greater	great	JJR
cord-001835-0s7ok4uw	350	6	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	350	7	insight	insight	NN
cord-001835-0s7ok4uw	350	8	into	into	IN
cord-001835-0s7ok4uw	350	9	the	the	DT
cord-001835-0s7ok4uw	350	10	regulation	regulation	NN
cord-001835-0s7ok4uw	350	11	of	of	IN
cord-001835-0s7ok4uw	350	12	promoter	promoter	NN
cord-001835-0s7ok4uw	350	13	-	-	HYPH
cord-001835-0s7ok4uw	350	14	proximal	proximal	JJ
cord-001835-0s7ok4uw	350	15	PolII	polii	NN
cord-001835-0s7ok4uw	350	16	pausing	pause	VBG
cord-001835-0s7ok4uw	350	17	,	,	,
cord-001835-0s7ok4uw	350	18	we	-PRON-	PRP
cord-001835-0s7ok4uw	350	19	have	have	VBP
cord-001835-0s7ok4uw	350	20	been	be	VBN
cord-001835-0s7ok4uw	350	21	developing	develop	VBG
cord-001835-0s7ok4uw	350	22	a	a	DT
cord-001835-0s7ok4uw	350	23	diffusion	diffusion	NN
cord-001835-0s7ok4uw	350	24	-	-	HYPH
cord-001835-0s7ok4uw	350	25	based	base	VBN
cord-001835-0s7ok4uw	350	26	single	single	JJ
cord-001835-0s7ok4uw	350	27	-	-	HYPH
cord-001835-0s7ok4uw	350	28	molecule	molecule	NN
cord-001835-0s7ok4uw	350	29	method	method	NN
cord-001835-0s7ok4uw	350	30	using	use	VBG
cord-001835-0s7ok4uw	350	31	alternating	alternate	VBG
cord-001835-0s7ok4uw	350	32	laser	laser	NN
cord-001835-0s7ok4uw	350	33	excitation	excitation	NN
cord-001835-0s7ok4uw	350	34	on	on	IN
cord-001835-0s7ok4uw	350	35	the	the	DT
cord-001835-0s7ok4uw	350	36	micro	micro	JJ
cord-001835-0s7ok4uw	350	37	-	-	JJ
cord-001835-0s7ok4uw	350	38	second	second	JJ
cord-001835-0s7ok4uw	350	39	timescale	timescale	NN
cord-001835-0s7ok4uw	350	40	(	(	-LRB-
cord-001835-0s7ok4uw	350	41	msALEX	msALEX	NNP
cord-001835-0s7ok4uw	350	42	)	)	-RRB-
cord-001835-0s7ok4uw	350	43	.	.	.
cord-001835-0s7ok4uw	351	1	The	the	DT
cord-001835-0s7ok4uw	351	2	method	method	NN
cord-001835-0s7ok4uw	351	3	detects	detect	VBZ
cord-001835-0s7ok4uw	351	4	RNA	RNA	NNP
cord-001835-0s7ok4uw	351	5	transcripts	transcript	NNS
cord-001835-0s7ok4uw	351	6	generated	generate	VBN
cord-001835-0s7ok4uw	351	7	by	by	IN
cord-001835-0s7ok4uw	351	8	a	a	DT
cord-001835-0s7ok4uw	351	9	reconstituted	reconstitute	VBN
cord-001835-0s7ok4uw	351	10	human	human	JJ
cord-001835-0s7ok4uw	351	11	PolII	polii	NN
cord-001835-0s7ok4uw	351	12	system	system	NN
cord-001835-0s7ok4uw	351	13	in	in	IN
cord-001835-0s7ok4uw	351	14	vitro	vitro	FW
cord-001835-0s7ok4uw	351	15	using	use	VBG
cord-001835-0s7ok4uw	351	16	complementary	complementary	JJ
cord-001835-0s7ok4uw	351	17	doubly	doubly	RB
cord-001835-0s7ok4uw	351	18	dye	dye	NN
cord-001835-0s7ok4uw	351	19	-	-	HYPH
cord-001835-0s7ok4uw	351	20	labeled	label	VBN
cord-001835-0s7ok4uw	351	21	single	single	RB
cord-001835-0s7ok4uw	351	22	-	-	HYPH
cord-001835-0s7ok4uw	351	23	stranded	strand	VBN
cord-001835-0s7ok4uw	351	24	DNA	dna	NN
cord-001835-0s7ok4uw	351	25	(	(	-LRB-
cord-001835-0s7ok4uw	351	26	ssDNA	ssdna	NN
cord-001835-0s7ok4uw	351	27	)	)	-RRB-
cord-001835-0s7ok4uw	351	28	probes	probe	NNS
cord-001835-0s7ok4uw	351	29	.	.	.
cord-001835-0s7ok4uw	352	1	The	the	DT
cord-001835-0s7ok4uw	352	2	human	human	JJ
cord-001835-0s7ok4uw	352	3	gene	gene	NN
cord-001835-0s7ok4uw	352	4	HSPA1B	HSPA1B	NNP
cord-001835-0s7ok4uw	352	5	for	for	IN
cord-001835-0s7ok4uw	352	6	heat	heat	NN
cord-001835-0s7ok4uw	352	7	shock	shock	NN
cord-001835-0s7ok4uw	352	8	protein	protein	NN
cord-001835-0s7ok4uw	352	9	70	70	CD
cord-001835-0s7ok4uw	352	10	(	(	-LRB-
cord-001835-0s7ok4uw	352	11	Hsp70	Hsp70	NNP
cord-001835-0s7ok4uw	352	12	)	)	-RRB-
cord-001835-0s7ok4uw	352	13	is	be	VBZ
cord-001835-0s7ok4uw	352	14	used	use	VBN
cord-001835-0s7ok4uw	352	15	as	as	IN
cord-001835-0s7ok4uw	352	16	a	a	DT
cord-001835-0s7ok4uw	352	17	model	model	NN
cord-001835-0s7ok4uw	352	18	system	system	NN
cord-001835-0s7ok4uw	352	19	due	due	IN
cord-001835-0s7ok4uw	352	20	to	to	IN
cord-001835-0s7ok4uw	352	21	its	-PRON-	PRP$
cord-001835-0s7ok4uw	352	22	extensive	extensive	JJ
cord-001835-0s7ok4uw	352	23	characterization	characterization	NN
cord-001835-0s7ok4uw	352	24	in	in	IN
cord-001835-0s7ok4uw	352	25	drosophila	drosophila	NN
cord-001835-0s7ok4uw	352	26	.	.	.
cord-001835-0s7ok4uw	353	1	The	the	DT
cord-001835-0s7ok4uw	353	2	method	method	NN
cord-001835-0s7ok4uw	353	3	would	would	MD
cord-001835-0s7ok4uw	353	4	provide	provide	VB
cord-001835-0s7ok4uw	353	5	a	a	DT
cord-001835-0s7ok4uw	353	6	rapid	rapid	JJ
cord-001835-0s7ok4uw	353	7	,	,	,
cord-001835-0s7ok4uw	353	8	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	353	9	and	and	CC
cord-001835-0s7ok4uw	353	10	robust	robust	JJ
cord-001835-0s7ok4uw	353	11	avenue	avenue	NN
cord-001835-0s7ok4uw	353	12	to	to	TO
cord-001835-0s7ok4uw	353	13	screen	screen	VB
cord-001835-0s7ok4uw	353	14	for	for	IN
cord-001835-0s7ok4uw	353	15	protein	protein	NN
cord-001835-0s7ok4uw	353	16	factors	factor	NNS
cord-001835-0s7ok4uw	353	17	regulating	regulate	VBG
cord-001835-0s7ok4uw	353	18	promoter	promoter	NN
cord-001835-0s7ok4uw	353	19	-	-	HYPH
cord-001835-0s7ok4uw	353	20	proximal	proximal	JJ
cord-001835-0s7ok4uw	353	21	PolII	polii	NN
cord-001835-0s7ok4uw	353	22	pausing	pause	VBG
cord-001835-0s7ok4uw	353	23	.	.	.
cord-001835-0s7ok4uw	354	1	Controlling	control	VBG
cord-001835-0s7ok4uw	354	2	of	of	IN
cord-001835-0s7ok4uw	354	3	the	the	DT
cord-001835-0s7ok4uw	354	4	PIC	pic	NN
cord-001835-0s7ok4uw	354	5	composition	composition	NN
cord-001835-0s7ok4uw	354	6	using	use	VBG
cord-001835-0s7ok4uw	354	7	the	the	DT
cord-001835-0s7ok4uw	354	8	reconstituted	reconstitute	VBN
cord-001835-0s7ok4uw	354	9	system	system	NN
cord-001835-0s7ok4uw	354	10	allows	allow	VBZ
cord-001835-0s7ok4uw	354	11	for	for	IN
cord-001835-0s7ok4uw	354	12	dissection	dissection	NN
cord-001835-0s7ok4uw	354	13	of	of	IN
cord-001835-0s7ok4uw	354	14	the	the	DT
cord-001835-0s7ok4uw	354	15	functional	functional	JJ
cord-001835-0s7ok4uw	354	16	roles	role	NNS
cord-001835-0s7ok4uw	354	17	of	of	IN
cord-001835-0s7ok4uw	354	18	different	different	JJ
cord-001835-0s7ok4uw	354	19	PIC	pic	NN
cord-001835-0s7ok4uw	354	20	components	component	NNS
cord-001835-0s7ok4uw	354	21	in	in	IN
cord-001835-0s7ok4uw	354	22	facilitating	facilitate	VBG
cord-001835-0s7ok4uw	354	23	regulation	regulation	NN
cord-001835-0s7ok4uw	354	24	of	of	IN
cord-001835-0s7ok4uw	354	25	PolII	polii	NN
cord-001835-0s7ok4uw	354	26	pausing	pause	VBG
cord-001835-0s7ok4uw	354	27	.	.	.
cord-001835-0s7ok4uw	355	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	355	2	have	have	VBP
cord-001835-0s7ok4uw	355	3	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	355	4	the	the	DT
cord-001835-0s7ok4uw	355	5	hybridization	hybridization	NN
cord-001835-0s7ok4uw	355	6	of	of	IN
cord-001835-0s7ok4uw	355	7	double	double	JJ
cord-001835-0s7ok4uw	355	8	dye	dye	NN
cord-001835-0s7ok4uw	355	9	-	-	HYPH
cord-001835-0s7ok4uw	355	10	labeled	label	VBN
cord-001835-0s7ok4uw	355	11	ssDNA	ssdna	NN
cord-001835-0s7ok4uw	355	12	probe	probe	NN
cord-001835-0s7ok4uw	355	13	to	to	IN
cord-001835-0s7ok4uw	355	14	complementary	complementary	JJ
cord-001835-0s7ok4uw	355	15	ssDNA	ssdna	RB
cord-001835-0s7ok4uw	355	16	mimicking	mimic	VBG
cord-001835-0s7ok4uw	355	17	RNA	RNA	NNP
cord-001835-0s7ok4uw	355	18	transcripts	transcript	NNS
cord-001835-0s7ok4uw	355	19	and	and	CC
cord-001835-0s7ok4uw	355	20	to	to	IN
cord-001835-0s7ok4uw	355	21	transcripts	transcript	NNS
cord-001835-0s7ok4uw	355	22	generated	generate	VBN
cord-001835-0s7ok4uw	355	23	with	with	IN
cord-001835-0s7ok4uw	355	24	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	355	25	RNA	RNA	NNP
cord-001835-0s7ok4uw	355	26	polymerase	polymerase	NN
cord-001835-0s7ok4uw	355	27	.	.	.
cord-001835-0s7ok4uw	356	1	Also	also	RB
cord-001835-0s7ok4uw	356	2	,	,	,
cord-001835-0s7ok4uw	356	3	a	a	DT
cord-001835-0s7ok4uw	356	4	functional	functional	JJ
cord-001835-0s7ok4uw	356	5	reconstituted	reconstitute	VBN
cord-001835-0s7ok4uw	356	6	human	human	JJ
cord-001835-0s7ok4uw	356	7	PolII	polii	NN
cord-001835-0s7ok4uw	356	8	system	system	NN
cord-001835-0s7ok4uw	356	9	has	have	VBZ
cord-001835-0s7ok4uw	356	10	been	be	VBN
cord-001835-0s7ok4uw	356	11	verified	verify	VBN
cord-001835-0s7ok4uw	356	12	using	use	VBG
cord-001835-0s7ok4uw	356	13	radioactive	radioactive	JJ
cord-001835-0s7ok4uw	356	14	polyacrylamide	polyacrylamide	NN
cord-001835-0s7ok4uw	356	15	gel	gel	NN
cord-001835-0s7ok4uw	356	16	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	356	17	of	of	IN
cord-001835-0s7ok4uw	356	18	transcripts	transcript	NNS
cord-001835-0s7ok4uw	356	19	from	from	IN
cord-001835-0s7ok4uw	356	20	in	in	IN
cord-001835-0s7ok4uw	356	21	vitro	vitro	FW
cord-001835-0s7ok4uw	356	22	transcription	transcription	NN
cord-001835-0s7ok4uw	356	23	assays	assay	NNS
cord-001835-0s7ok4uw	356	24	.	.	.
cord-001835-0s7ok4uw	357	1	Malaria	malaria	NN
cord-001835-0s7ok4uw	357	2	is	be	VBZ
cord-001835-0s7ok4uw	357	3	a	a	DT
cord-001835-0s7ok4uw	357	4	major	major	JJ
cord-001835-0s7ok4uw	357	5	global	global	JJ
cord-001835-0s7ok4uw	357	6	health	health	NN
cord-001835-0s7ok4uw	357	7	problem	problem	NN
cord-001835-0s7ok4uw	357	8	.	.	.
cord-001835-0s7ok4uw	358	1	In	in	IN
cord-001835-0s7ok4uw	358	2	2013	2013	CD
cord-001835-0s7ok4uw	358	3	,	,	,
cord-001835-0s7ok4uw	358	4	there	there	EX
cord-001835-0s7ok4uw	358	5	were	be	VBD
cord-001835-0s7ok4uw	358	6	an	an	DT
cord-001835-0s7ok4uw	358	7	estimated	estimate	VBN
cord-001835-0s7ok4uw	358	8	128	128	CD
cord-001835-0s7ok4uw	358	9	million	million	CD
cord-001835-0s7ok4uw	358	10	case	case	NN
cord-001835-0s7ok4uw	358	11	of	of	IN
cord-001835-0s7ok4uw	358	12	malaria	malaria	NN
cord-001835-0s7ok4uw	358	13	and	and	CC
cord-001835-0s7ok4uw	358	14	584	584	CD
cord-001835-0s7ok4uw	358	15	000	000	CD
cord-001835-0s7ok4uw	358	16	deaths	death	NNS
cord-001835-0s7ok4uw	358	17	,	,	,
cord-001835-0s7ok4uw	358	18	most	most	JJS
cord-001835-0s7ok4uw	358	19	of	of	IN
cord-001835-0s7ok4uw	358	20	them	-PRON-	PRP
cord-001835-0s7ok4uw	358	21	children	child	NNS
cord-001835-0s7ok4uw	358	22	under	under	IN
cord-001835-0s7ok4uw	358	23	5	5	CD
cord-001835-0s7ok4uw	358	24	years	year	NNS
cord-001835-0s7ok4uw	358	25	old	old	JJ
cord-001835-0s7ok4uw	358	26	[	[	-LRB-
cord-001835-0s7ok4uw	358	27	1	1	CD
cord-001835-0s7ok4uw	358	28	]	]	-RRB-
cord-001835-0s7ok4uw	358	29	.	.	.
cord-001835-0s7ok4uw	359	1	Among	among	IN
cord-001835-0s7ok4uw	359	2	the	the	DT
cord-001835-0s7ok4uw	359	3	5	5	CD
cord-001835-0s7ok4uw	359	4	malaria	malaria	NN
cord-001835-0s7ok4uw	359	5	species	specie	NNS
cord-001835-0s7ok4uw	359	6	that	that	WDT
cord-001835-0s7ok4uw	359	7	affect	affect	VBP
cord-001835-0s7ok4uw	359	8	humans	human	NNS
cord-001835-0s7ok4uw	359	9	,	,	,
cord-001835-0s7ok4uw	359	10	Plasmodium	plasmodium	NN
cord-001835-0s7ok4uw	359	11	falciparum	falciparum	NN
cord-001835-0s7ok4uw	359	12	is	be	VBZ
cord-001835-0s7ok4uw	359	13	the	the	DT
cord-001835-0s7ok4uw	359	14	most	most	RBS
cord-001835-0s7ok4uw	359	15	deadly	deadly	JJ
cord-001835-0s7ok4uw	359	16	form	form	NN
cord-001835-0s7ok4uw	359	17	.	.	.
cord-001835-0s7ok4uw	360	1	Since	since	IN
cord-001835-0s7ok4uw	360	2	no	no	DT
cord-001835-0s7ok4uw	360	3	efficient	efficient	JJ
cord-001835-0s7ok4uw	360	4	vaccine	vaccine	NN
cord-001835-0s7ok4uw	360	5	is	be	VBZ
cord-001835-0s7ok4uw	360	6	available	available	JJ
cord-001835-0s7ok4uw	360	7	yet	yet	RB
cord-001835-0s7ok4uw	360	8	,	,	,
cord-001835-0s7ok4uw	360	9	the	the	DT
cord-001835-0s7ok4uw	360	10	fight	fight	NN
cord-001835-0s7ok4uw	360	11	against	against	IN
cord-001835-0s7ok4uw	360	12	malaria	malaria	NN
cord-001835-0s7ok4uw	360	13	includes	include	VBZ
cord-001835-0s7ok4uw	360	14	vector	vector	NN
cord-001835-0s7ok4uw	360	15	control	control	NN
cord-001835-0s7ok4uw	360	16	,	,	,
cord-001835-0s7ok4uw	360	17	protection	protection	NN
cord-001835-0s7ok4uw	360	18	from	from	IN
cord-001835-0s7ok4uw	360	19	mosquito	mosquito	NN
cord-001835-0s7ok4uw	360	20	bites	bite	NNS
cord-001835-0s7ok4uw	360	21	and	and	CC
cord-001835-0s7ok4uw	360	22	artemisinin	artemisinin	NN
cord-001835-0s7ok4uw	360	23	combined	combine	VBN
cord-001835-0s7ok4uw	360	24	therapy	therapy	NN
cord-001835-0s7ok4uw	360	25	.	.	.
cord-001835-0s7ok4uw	361	1	However	however	RB
cord-001835-0s7ok4uw	361	2	,	,	,
cord-001835-0s7ok4uw	361	3	resistances	resistance	NNS
cord-001835-0s7ok4uw	361	4	to	to	IN
cord-001835-0s7ok4uw	361	5	all	all	DT
cord-001835-0s7ok4uw	361	6	known	know	VBN
cord-001835-0s7ok4uw	361	7	treatments	treatment	NNS
cord-001835-0s7ok4uw	361	8	have	have	VBP
cord-001835-0s7ok4uw	361	9	been	be	VBN
cord-001835-0s7ok4uw	361	10	observed	observe	VBN
cord-001835-0s7ok4uw	361	11	.	.	.
cord-001835-0s7ok4uw	362	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	362	2	,	,	,
cord-001835-0s7ok4uw	362	3	new	new	JJ
cord-001835-0s7ok4uw	362	4	antimalarial	antimalarial	JJ
cord-001835-0s7ok4uw	362	5	strategies	strategy	NNS
cord-001835-0s7ok4uw	362	6	involving	involve	VBG
cord-001835-0s7ok4uw	362	7	novel	novel	JJ
cord-001835-0s7ok4uw	362	8	targets	target	NNS
cord-001835-0s7ok4uw	362	9	and	and	CC
cord-001835-0s7ok4uw	362	10	new	new	JJ
cord-001835-0s7ok4uw	362	11	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	362	12	of	of	IN
cord-001835-0s7ok4uw	362	13	action	action	NN
cord-001835-0s7ok4uw	362	14	are	be	VBP
cord-001835-0s7ok4uw	362	15	needed	need	VBN
cord-001835-0s7ok4uw	362	16	.	.	.
cord-001835-0s7ok4uw	363	1	During	during	IN
cord-001835-0s7ok4uw	363	2	its	-PRON-	PRP$
cord-001835-0s7ok4uw	363	3	life	life	NN
cord-001835-0s7ok4uw	363	4	cycle	cycle	NN
cord-001835-0s7ok4uw	363	5	,	,	,
cord-001835-0s7ok4uw	363	6	in	in	IN
cord-001835-0s7ok4uw	363	7	erythrocytic	erythrocytic	JJ
cord-001835-0s7ok4uw	363	8	stage	stage	NN
cord-001835-0s7ok4uw	363	9	,	,	,
cord-001835-0s7ok4uw	363	10	which	which	WDT
cord-001835-0s7ok4uw	363	11	causes	cause	VBZ
cord-001835-0s7ok4uw	363	12	all	all	PDT
cord-001835-0s7ok4uw	363	13	the	the	DT
cord-001835-0s7ok4uw	363	14	malaria	malaria	NN
cord-001835-0s7ok4uw	363	15	symptoms	symptom	NNS
cord-001835-0s7ok4uw	363	16	,	,	,
cord-001835-0s7ok4uw	363	17	Plasmodium	plasmodium	NN
cord-001835-0s7ok4uw	363	18	falciparum	falciparum	NN
cord-001835-0s7ok4uw	363	19	relies	rely	VBZ
cord-001835-0s7ok4uw	363	20	on	on	IN
cord-001835-0s7ok4uw	363	21	phospholipids	phospholipid	NNS
cord-001835-0s7ok4uw	363	22	to	to	TO
cord-001835-0s7ok4uw	363	23	build	build	VB
cord-001835-0s7ok4uw	363	24	the	the	DT
cord-001835-0s7ok4uw	363	25	membranes	membrane	NNS
cord-001835-0s7ok4uw	363	26	necessary	necessary	JJ
cord-001835-0s7ok4uw	363	27	for	for	IN
cord-001835-0s7ok4uw	363	28	daughter	daughter	NN
cord-001835-0s7ok4uw	363	29	cell	cell	NN
cord-001835-0s7ok4uw	363	30	development	development	NN
cord-001835-0s7ok4uw	363	31	.	.	.
cord-001835-0s7ok4uw	364	1	Approximately	approximately	RB
cord-001835-0s7ok4uw	364	2	85	85	CD
cord-001835-0s7ok4uw	364	3	%	%	NN
cord-001835-0s7ok4uw	364	4	of	of	IN
cord-001835-0s7ok4uw	364	5	parasite	parasite	NN
cord-001835-0s7ok4uw	364	6	phospholipids	phospholipid	NNS
cord-001835-0s7ok4uw	364	7	consist	consist	VBP
cord-001835-0s7ok4uw	364	8	of	of	IN
cord-001835-0s7ok4uw	364	9	phosphatidylcholine	phosphatidylcholine	NN
cord-001835-0s7ok4uw	364	10	(	(	-LRB-
cord-001835-0s7ok4uw	364	11	PC	pc	NN
cord-001835-0s7ok4uw	364	12	)	)	-RRB-
cord-001835-0s7ok4uw	364	13	and	and	CC
cord-001835-0s7ok4uw	364	14	phosphatidylethanolamine	phosphatidylethanolamine	NNP
cord-001835-0s7ok4uw	364	15	(	(	-LRB-
cord-001835-0s7ok4uw	364	16	PE	PE	NNP
cord-001835-0s7ok4uw	364	17	)	)	-RRB-
cord-001835-0s7ok4uw	364	18	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	364	19	by	by	IN
cord-001835-0s7ok4uw	364	20	the	the	DT
cord-001835-0s7ok4uw	364	21	parasite	parasite	NN
cord-001835-0s7ok4uw	364	22	through	through	IN
cord-001835-0s7ok4uw	364	23	the	the	DT
cord-001835-0s7ok4uw	364	24	de	de	FW
cord-001835-0s7ok4uw	364	25	novo	novo	NNP
cord-001835-0s7ok4uw	364	26	Kennedy	Kennedy	NNP
cord-001835-0s7ok4uw	364	27	pathways	pathway	NNS
cord-001835-0s7ok4uw	364	28	.	.	.
cord-001835-0s7ok4uw	365	1	In	in	IN
cord-001835-0s7ok4uw	365	2	the	the	DT
cord-001835-0s7ok4uw	365	3	pathway	pathway	NN
cord-001835-0s7ok4uw	365	4	of	of	IN
cord-001835-0s7ok4uw	365	5	phosphatidylcholine	phosphatidylcholine	NNP
cord-001835-0s7ok4uw	365	6	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	365	7	,	,	,
cord-001835-0s7ok4uw	365	8	the	the	DT
cord-001835-0s7ok4uw	365	9	second	second	JJ
cord-001835-0s7ok4uw	365	10	step	step	NN
cord-001835-0s7ok4uw	365	11	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	365	12	by	by	IN
cord-001835-0s7ok4uw	365	13	CTP	CTP	NNP
cord-001835-0s7ok4uw	365	14	:	:	:
cord-001835-0s7ok4uw	365	15	phosphocholine	phosphocholine	NNP
cord-001835-0s7ok4uw	365	16	cytidylyltransferase	cytidylyltransferase	NNP
cord-001835-0s7ok4uw	365	17	[	[	-LRB-
cord-001835-0s7ok4uw	365	18	EC	EC	NNP
cord-001835-0s7ok4uw	365	19	2.7.7.15	2.7.7.15	CD
cord-001835-0s7ok4uw	365	20	]	]	-RRB-
cord-001835-0s7ok4uw	365	21	is	be	VBZ
cord-001835-0s7ok4uw	365	22	rate	rate	NN
cord-001835-0s7ok4uw	365	23	limiting	limiting	NN
cord-001835-0s7ok4uw	365	24	and	and	CC
cord-001835-0s7ok4uw	365	25	appears	appear	VBZ
cord-001835-0s7ok4uw	365	26	essential	essential	JJ
cord-001835-0s7ok4uw	365	27	for	for	IN
cord-001835-0s7ok4uw	365	28	the	the	DT
cord-001835-0s7ok4uw	365	29	parasite	parasite	JJ
cord-001835-0s7ok4uw	365	30	survival	survival	NN
cord-001835-0s7ok4uw	365	31	at	at	IN
cord-001835-0s7ok4uw	365	32	its	-PRON-	PRP$
cord-001835-0s7ok4uw	365	33	blood	blood	NN
cord-001835-0s7ok4uw	365	34	stage	stage	NN
cord-001835-0s7ok4uw	365	35	[	[	-LRB-
cord-001835-0s7ok4uw	365	36	2	2	CD
cord-001835-0s7ok4uw	365	37	]	]	-RRB-
cord-001835-0s7ok4uw	365	38	[	[	-LRB-
cord-001835-0s7ok4uw	365	39	3	3	CD
cord-001835-0s7ok4uw	365	40	]	]	-RRB-
cord-001835-0s7ok4uw	365	41	.	.	.
cord-001835-0s7ok4uw	366	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	366	2	are	be	VBP
cord-001835-0s7ok4uw	366	3	focused	focus	VBN
cord-001835-0s7ok4uw	366	4	on	on	IN
cord-001835-0s7ok4uw	366	5	the	the	DT
cord-001835-0s7ok4uw	366	6	structural	structural	JJ
cord-001835-0s7ok4uw	366	7	characterization	characterization	NN
cord-001835-0s7ok4uw	366	8	of	of	IN
cord-001835-0s7ok4uw	366	9	this	this	DT
cord-001835-0s7ok4uw	366	10	enzyme	enzyme	NN
cord-001835-0s7ok4uw	366	11	,	,	,
cord-001835-0s7ok4uw	366	12	the	the	DT
cord-001835-0s7ok4uw	366	13	identification	identification	NN
cord-001835-0s7ok4uw	366	14	of	of	IN
cord-001835-0s7ok4uw	366	15	effectors	effector	NNS
cord-001835-0s7ok4uw	366	16	by	by	IN
cord-001835-0s7ok4uw	366	17	fragment	fragment	NN
cord-001835-0s7ok4uw	366	18	-	-	HYPH
cord-001835-0s7ok4uw	366	19	based	base	VBN
cord-001835-0s7ok4uw	366	20	drug	drug	NN
cord-001835-0s7ok4uw	366	21	design	design	NN
cord-001835-0s7ok4uw	366	22	approach	approach	NN
cord-001835-0s7ok4uw	366	23	(	(	-LRB-
cord-001835-0s7ok4uw	366	24	FBDD	FBDD	NNP
cord-001835-0s7ok4uw	366	25	)	)	-RRB-
cord-001835-0s7ok4uw	366	26	and	and	CC
cord-001835-0s7ok4uw	366	27	then	then	RB
cord-001835-0s7ok4uw	366	28	their	-PRON-	PRP$
cord-001835-0s7ok4uw	366	29	optimization	optimization	NN
cord-001835-0s7ok4uw	366	30	to	to	TO
cord-001835-0s7ok4uw	366	31	eventually	eventually	RB
cord-001835-0s7ok4uw	366	32	design	design	VB
cord-001835-0s7ok4uw	366	33	a	a	DT
cord-001835-0s7ok4uw	366	34	lead	lead	NN
cord-001835-0s7ok4uw	366	35	.	.	.
cord-001835-0s7ok4uw	367	1	The	the	DT
cord-001835-0s7ok4uw	367	2	first	first	JJ
cord-001835-0s7ok4uw	367	3	reported	report	VBN
cord-001835-0s7ok4uw	367	4	crystal	crystal	NN
cord-001835-0s7ok4uw	367	5	structure	structure	NN
cord-001835-0s7ok4uw	367	6	of	of	IN
cord-001835-0s7ok4uw	367	7	the	the	DT
cord-001835-0s7ok4uw	367	8	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	367	9	domain	domain	NN
cord-001835-0s7ok4uw	367	10	of	of	IN
cord-001835-0s7ok4uw	367	11	the	the	DT
cord-001835-0s7ok4uw	367	12	enzyme	enzyme	NN
cord-001835-0s7ok4uw	367	13	target	target	NN
cord-001835-0s7ok4uw	367	14	(	(	-LRB-
cord-001835-0s7ok4uw	367	15	PfCCT	PfCCT	NNP
cord-001835-0s7ok4uw	367	16	)	)	-RRB-
cord-001835-0s7ok4uw	367	17	has	have	VBZ
cord-001835-0s7ok4uw	367	18	been	be	VBN
cord-001835-0s7ok4uw	367	19	solved	solve	VBN
cord-001835-0s7ok4uw	367	20	at	at	IN
cord-001835-0s7ok4uw	367	21	resolution	resolution	NN
cord-001835-0s7ok4uw	367	22	2.2	2.2	CD
cord-001835-0s7ok4uw	367	23	Å	å	NN
cord-001835-0s7ok4uw	367	24	,	,	,
cord-001835-0s7ok4uw	367	25	3	3	CD
cord-001835-0s7ok4uw	367	26	enzyme	enzyme	NN
cord-001835-0s7ok4uw	367	27	-	-	HYPH
cord-001835-0s7ok4uw	367	28	substrates	substrate	NNS
cord-001835-0s7ok4uw	367	29	complexes	complex	NNS
cord-001835-0s7ok4uw	367	30	(	(	-LRB-
cord-001835-0s7ok4uw	367	31	CMP-	CMP-	NNP
cord-001835-0s7ok4uw	367	32	,	,	,
cord-001835-0s7ok4uw	367	33	phosphocholine	phosphocholine	JJ
cord-001835-0s7ok4uw	367	34	-	-	HYPH
cord-001835-0s7ok4uw	367	35	and	and	CC
cord-001835-0s7ok4uw	367	36	choline	choline	NN
cord-001835-0s7ok4uw	367	37	-	-	HYPH
cord-001835-0s7ok4uw	367	38	bound	bind	VBN
cord-001835-0s7ok4uw	367	39	forms	form	NNS
cord-001835-0s7ok4uw	367	40	)	)	-RRB-
cord-001835-0s7ok4uw	367	41	at	at	IN
cord-001835-0s7ok4uw	367	42	resolutions	resolution	NNS
cord-001835-0s7ok4uw	367	43	1.9	1.9	CD
cord-001835-0s7ok4uw	367	44	-	-	SYM
cord-001835-0s7ok4uw	367	45	2	2	CD
cord-001835-0s7ok4uw	367	46	Å	å	NN
cord-001835-0s7ok4uw	367	47	and	and	CC
cord-001835-0s7ok4uw	367	48	an	an	DT
cord-001835-0s7ok4uw	367	49	enzyme	enzyme	NN
cord-001835-0s7ok4uw	367	50	-	-	HYPH
cord-001835-0s7ok4uw	367	51	product	product	NN
cord-001835-0s7ok4uw	367	52	(	(	-LRB-
cord-001835-0s7ok4uw	367	53	CDP	CDP	NNP
cord-001835-0s7ok4uw	367	54	-	-	HYPH
cord-001835-0s7ok4uw	367	55	choline	choline	NNP
cord-001835-0s7ok4uw	367	56	)	)	-RRB-
cord-001835-0s7ok4uw	367	57	complex	complex	JJ
cord-001835-0s7ok4uw	367	58	structure	structure	NN
cord-001835-0s7ok4uw	367	59	at	at	IN
cord-001835-0s7ok4uw	367	60	resolution	resolution	NN
cord-001835-0s7ok4uw	367	61	2.4	2.4	CD
cord-001835-0s7ok4uw	367	62	Å	å	NN
cord-001835-0s7ok4uw	367	63	that	that	WDT
cord-001835-0s7ok4uw	367	64	give	give	VBP
cord-001835-0s7ok4uw	367	65	detailed	detailed	JJ
cord-001835-0s7ok4uw	367	66	images	image	NNS
cord-001835-0s7ok4uw	367	67	of	of	IN
cord-001835-0s7ok4uw	367	68	binding	bind	VBG
cord-001835-0s7ok4uw	367	69	pocket	pocket	NN
cord-001835-0s7ok4uw	367	70	,	,	,
cord-001835-0s7ok4uw	367	71	demonstrate	demonstrate	VB
cord-001835-0s7ok4uw	367	72	conformational	conformational	JJ
cord-001835-0s7ok4uw	367	73	changes	change	NNS
cord-001835-0s7ok4uw	367	74	between	between	IN
cord-001835-0s7ok4uw	367	75	apo	apo	NNP
cord-001835-0s7ok4uw	367	76	-	-	HYPH
cord-001835-0s7ok4uw	367	77	and	and	CC
cord-001835-0s7ok4uw	367	78	holo	holo	JJ
cord-001835-0s7ok4uw	367	79	-	-	HYPH
cord-001835-0s7ok4uw	367	80	protein	protein	NN
cord-001835-0s7ok4uw	367	81	forms	form	NNS
cord-001835-0s7ok4uw	367	82	and	and	CC
cord-001835-0s7ok4uw	367	83	provide	provide	VB
cord-001835-0s7ok4uw	367	84	the	the	DT
cord-001835-0s7ok4uw	367	85	information	information	NN
cord-001835-0s7ok4uw	367	86	about	about	IN
cord-001835-0s7ok4uw	367	87	the	the	DT
cord-001835-0s7ok4uw	367	88	mechanism	mechanism	NN
cord-001835-0s7ok4uw	367	89	of	of	IN
cord-001835-0s7ok4uw	367	90	the	the	DT
cord-001835-0s7ok4uw	367	91	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	367	92	reaction	reaction	NN
cord-001835-0s7ok4uw	367	93	at	at	IN
cord-001835-0s7ok4uw	367	94	atomic	atomic	JJ
cord-001835-0s7ok4uw	367	95	level	level	NN
cord-001835-0s7ok4uw	367	96	.	.	.
cord-001835-0s7ok4uw	368	1	The	the	DT
cord-001835-0s7ok4uw	368	2	FBDD	FBDD	NNP
cord-001835-0s7ok4uw	368	3	method	method	NN
cord-001835-0s7ok4uw	368	4	uses	use	VBZ
cord-001835-0s7ok4uw	368	5	a	a	DT
cord-001835-0s7ok4uw	368	6	library	library	NN
cord-001835-0s7ok4uw	368	7	of	of	IN
cord-001835-0s7ok4uw	368	8	small	small	JJ
cord-001835-0s7ok4uw	368	9	molecules	molecule	NNS
cord-001835-0s7ok4uw	368	10	(	(	-LRB-
cord-001835-0s7ok4uw	368	11	fragments	fragment	NNS
cord-001835-0s7ok4uw	368	12	)	)	-RRB-
cord-001835-0s7ok4uw	368	13	with	with	IN
cord-001835-0s7ok4uw	368	14	molecular	molecular	JJ
cord-001835-0s7ok4uw	368	15	weight	weight	NN
cord-001835-0s7ok4uw	368	16	that	that	WDT
cord-001835-0s7ok4uw	368	17	does	do	VBZ
cord-001835-0s7ok4uw	368	18	not	not	RB
cord-001835-0s7ok4uw	368	19	exceed	exceed	VB
cord-001835-0s7ok4uw	368	20	300	300	CD
cord-001835-0s7ok4uw	368	21	Da	Da	NNP
cord-001835-0s7ok4uw	368	22	to	to	TO
cord-001835-0s7ok4uw	368	23	explore	explore	VB
cord-001835-0s7ok4uw	368	24	target	target	NN
cord-001835-0s7ok4uw	368	25	binding	bind	VBG
cord-001835-0s7ok4uw	368	26	sites	site	NNS
cord-001835-0s7ok4uw	368	27	.	.	.
cord-001835-0s7ok4uw	369	1	Although	although	IN
cord-001835-0s7ok4uw	369	2	fragments	fragment	NNS
cord-001835-0s7ok4uw	369	3	often	often	RB
cord-001835-0s7ok4uw	369	4	have	have	VBP
cord-001835-0s7ok4uw	369	5	too	too	RB
cord-001835-0s7ok4uw	369	6	low	low	JJ
cord-001835-0s7ok4uw	369	7	affinities	affinity	NNS
cord-001835-0s7ok4uw	369	8	to	to	TO
cord-001835-0s7ok4uw	369	9	evoke	evoke	VB
cord-001835-0s7ok4uw	369	10	a	a	DT
cord-001835-0s7ok4uw	369	11	biological	biological	JJ
cord-001835-0s7ok4uw	369	12	response	response	NN
cord-001835-0s7ok4uw	369	13	,	,	,
cord-001835-0s7ok4uw	369	14	their	-PRON-	PRP$
cord-001835-0s7ok4uw	369	15	probability	probability	NN
cord-001835-0s7ok4uw	369	16	of	of	IN
cord-001835-0s7ok4uw	369	17	binding	binding	NN
cord-001835-0s7ok4uw	369	18	is	be	VBZ
cord-001835-0s7ok4uw	369	19	high	high	JJ
cord-001835-0s7ok4uw	369	20	because	because	IN
cord-001835-0s7ok4uw	369	21	they	-PRON-	PRP
cord-001835-0s7ok4uw	369	22	are	be	VBP
cord-001835-0s7ok4uw	369	23	small	small	JJ
cord-001835-0s7ok4uw	369	24	enough	enough	RB
cord-001835-0s7ok4uw	369	25	to	to	TO
cord-001835-0s7ok4uw	369	26	prevent	prevent	VB
cord-001835-0s7ok4uw	369	27	unfavorable	unfavorable	JJ
cord-001835-0s7ok4uw	369	28	interactions	interaction	NNS
cord-001835-0s7ok4uw	369	29	with	with	IN
cord-001835-0s7ok4uw	369	30	target	target	NN
cord-001835-0s7ok4uw	369	31	protein	protein	NN
cord-001835-0s7ok4uw	369	32	-	-	HYPH
cord-001835-0s7ok4uw	369	33	binding	bind	VBG
cord-001835-0s7ok4uw	369	34	sites	site	NNS
cord-001835-0s7ok4uw	369	35	.	.	.
cord-001835-0s7ok4uw	370	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	370	2	,	,	,
cord-001835-0s7ok4uw	370	3	they	-PRON-	PRP
cord-001835-0s7ok4uw	370	4	represent	represent	VBP
cord-001835-0s7ok4uw	370	5	more	more	RBR
cord-001835-0s7ok4uw	370	6	attractive	attractive	JJ
cord-001835-0s7ok4uw	370	7	and	and	CC
cord-001835-0s7ok4uw	370	8	synthetically	synthetically	RB
cord-001835-0s7ok4uw	370	9	tractable	tractable	JJ
cord-001835-0s7ok4uw	370	10	starting	start	VBG
cord-001835-0s7ok4uw	370	11	points	point	NNS
cord-001835-0s7ok4uw	370	12	for	for	IN
cord-001835-0s7ok4uw	370	13	medicinal	medicinal	JJ
cord-001835-0s7ok4uw	370	14	chemistry	chemistry	NN
cord-001835-0s7ok4uw	370	15	compared	compare	VBN
cord-001835-0s7ok4uw	370	16	to	to	IN
cord-001835-0s7ok4uw	370	17	more	more	JJR
cord-001835-0s7ok4uw	370	18	complex	complex	JJ
cord-001835-0s7ok4uw	370	19	compounds	compound	NNS
cord-001835-0s7ok4uw	370	20	.	.	.
cord-001835-0s7ok4uw	371	1	As	as	IN
cord-001835-0s7ok4uw	371	2	the	the	DT
cord-001835-0s7ok4uw	371	3	affinity	affinity	NN
cord-001835-0s7ok4uw	371	4	is	be	VBZ
cord-001835-0s7ok4uw	371	5	low	low	JJ
cord-001835-0s7ok4uw	371	6	,	,	,
cord-001835-0s7ok4uw	371	7	fragment	fragment	NN
cord-001835-0s7ok4uw	371	8	screening	screening	NN
cord-001835-0s7ok4uw	371	9	usually	usually	RB
cord-001835-0s7ok4uw	371	10	depends	depend	VBZ
cord-001835-0s7ok4uw	371	11	on	on	IN
cord-001835-0s7ok4uw	371	12	detecting	detect	VBG
cord-001835-0s7ok4uw	371	13	binding	bind	VBG
cord-001835-0s7ok4uw	371	14	rather	rather	RB
cord-001835-0s7ok4uw	371	15	than	than	IN
cord-001835-0s7ok4uw	371	16	inhibition	inhibition	NN
cord-001835-0s7ok4uw	371	17	.	.	.
cord-001835-0s7ok4uw	372	1	Screenings	screening	NNS
cord-001835-0s7ok4uw	372	2	of	of	IN
cord-001835-0s7ok4uw	372	3	a	a	DT
cord-001835-0s7ok4uw	372	4	fragment	fragment	NN
cord-001835-0s7ok4uw	372	5	library	library	NN
cord-001835-0s7ok4uw	372	6	(	(	-LRB-
cord-001835-0s7ok4uw	372	7	300	300	CD
cord-001835-0s7ok4uw	372	8	molecules	molecule	NNS
cord-001835-0s7ok4uw	372	9	)	)	-RRB-
cord-001835-0s7ok4uw	372	10	has	have	VBZ
cord-001835-0s7ok4uw	372	11	been	be	VBN
cord-001835-0s7ok4uw	372	12	performed	perform	VBN
cord-001835-0s7ok4uw	372	13	by	by	IN
cord-001835-0s7ok4uw	372	14	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	372	15	-	-	HYPH
cord-001835-0s7ok4uw	372	16	based	base	VBN
cord-001835-0s7ok4uw	372	17	thermal	thermal	JJ
cord-001835-0s7ok4uw	372	18	shift	shift	NN
cord-001835-0s7ok4uw	372	19	assay	assay	NN
cord-001835-0s7ok4uw	372	20	and	and	CC
cord-001835-0s7ok4uw	372	21	Nuclear	Nuclear	NNP
cord-001835-0s7ok4uw	372	22	Magnetic	magnetic	JJ
cord-001835-0s7ok4uw	372	23	Resonance	resonance	NN
cord-001835-0s7ok4uw	372	24	Saturation	saturation	NN
cord-001835-0s7ok4uw	372	25	Transfer	transfer	NN
cord-001835-0s7ok4uw	372	26	Difference	difference	NN
cord-001835-0s7ok4uw	372	27	(	(	-LRB-
cord-001835-0s7ok4uw	372	28	NMR	NMR	NNP
cord-001835-0s7ok4uw	372	29	STD	STD	NNP
cord-001835-0s7ok4uw	372	30	)	)	-RRB-
cord-001835-0s7ok4uw	372	31	[	[	-LRB-
cord-001835-0s7ok4uw	372	32	4	4	CD
cord-001835-0s7ok4uw	372	33	]	]	-RRB-
cord-001835-0s7ok4uw	372	34	.	.	.
cord-001835-0s7ok4uw	373	1	This	this	DT
cord-001835-0s7ok4uw	373	2	combination	combination	NN
cord-001835-0s7ok4uw	373	3	of	of	IN
cord-001835-0s7ok4uw	373	4	techniques	technique	NNS
cord-001835-0s7ok4uw	373	5	identified	identify	VBN
cord-001835-0s7ok4uw	373	6	so	so	RB
cord-001835-0s7ok4uw	373	7	far	far	RB
cord-001835-0s7ok4uw	373	8	4	4	CD
cord-001835-0s7ok4uw	373	9	fragment	fragment	NN
cord-001835-0s7ok4uw	373	10	hits	hit	NNS
cord-001835-0s7ok4uw	373	11	that	that	WDT
cord-001835-0s7ok4uw	373	12	are	be	VBP
cord-001835-0s7ok4uw	373	13	currently	currently	RB
cord-001835-0s7ok4uw	373	14	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	373	15	for	for	IN
cord-001835-0s7ok4uw	373	16	their	-PRON-	PRP$
cord-001835-0s7ok4uw	373	17	binding	bind	VBG
cord-001835-0s7ok4uw	373	18	modes	mode	NNS
cord-001835-0s7ok4uw	373	19	and	and	CC
cord-001835-0s7ok4uw	373	20	affinities	affinity	NNS
cord-001835-0s7ok4uw	373	21	.	.	.
cord-001835-0s7ok4uw	374	1	Co	co	NN
cord-001835-0s7ok4uw	374	2	-	-	NN
cord-001835-0s7ok4uw	374	3	crystallization	crystallization	NN
cord-001835-0s7ok4uw	374	4	of	of	IN
cord-001835-0s7ok4uw	374	5	the	the	DT
cord-001835-0s7ok4uw	374	6	protein	protein	NN
cord-001835-0s7ok4uw	374	7	-	-	HYPH
cord-001835-0s7ok4uw	374	8	fragments	fragment	NNS
cord-001835-0s7ok4uw	374	9	complexes	complex	NNS
cord-001835-0s7ok4uw	374	10	is	be	VBZ
cord-001835-0s7ok4uw	374	11	carrying	carry	VBG
cord-001835-0s7ok4uw	374	12	out	out	RP
cord-001835-0s7ok4uw	374	13	to	to	TO
cord-001835-0s7ok4uw	374	14	provide	provide	VB
cord-001835-0s7ok4uw	374	15	accurate	accurate	JJ
cord-001835-0s7ok4uw	374	16	information	information	NN
cord-001835-0s7ok4uw	374	17	on	on	IN
cord-001835-0s7ok4uw	374	18	the	the	DT
cord-001835-0s7ok4uw	374	19	molecular	molecular	JJ
cord-001835-0s7ok4uw	374	20	interactions	interaction	NNS
cord-001835-0s7ok4uw	374	21	.	.	.
cord-001835-0s7ok4uw	375	1	Topology	topology	NN
cord-001835-0s7ok4uw	375	2	of	of	IN
cord-001835-0s7ok4uw	375	3	interactions	interaction	NNS
cord-001835-0s7ok4uw	375	4	will	will	MD
cord-001835-0s7ok4uw	375	5	be	be	VB
cord-001835-0s7ok4uw	375	6	used	use	VBN
cord-001835-0s7ok4uw	375	7	to	to	TO
cord-001835-0s7ok4uw	375	8	rationally	rationally	RB
cord-001835-0s7ok4uw	375	9	monitor	monitor	VB
cord-001835-0s7ok4uw	375	10	every	every	DT
cord-001835-0s7ok4uw	375	11	iterative	iterative	JJ
cord-001835-0s7ok4uw	375	12	round	round	NN
cord-001835-0s7ok4uw	375	13	of	of	IN
cord-001835-0s7ok4uw	375	14	the	the	DT
cord-001835-0s7ok4uw	375	15	optimization	optimization	NN
cord-001835-0s7ok4uw	375	16	process	process	NN
cord-001835-0s7ok4uw	375	17	allowing	allow	VBG
cord-001835-0s7ok4uw	375	18	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	375	19	rational	rational	JJ
cord-001835-0s7ok4uw	375	20	design	design	NN
cord-001835-0s7ok4uw	375	21	.	.	.
cord-001835-0s7ok4uw	376	1	[	[	-LRB-
cord-001835-0s7ok4uw	376	2	1	1	CD
cord-001835-0s7ok4uw	376	3	]	]	-RRB-
cord-001835-0s7ok4uw	376	4	World	World	NNP
cord-001835-0s7ok4uw	376	5	Health	Health	NNP
cord-001835-0s7ok4uw	376	6	organization	organization	NN
cord-001835-0s7ok4uw	376	7	,	,	,
cord-001835-0s7ok4uw	376	8	World	World	NNP
cord-001835-0s7ok4uw	376	9	Malaria	Malaria	NNP
cord-001835-0s7ok4uw	376	10	Report	Report	NNP
cord-001835-0s7ok4uw	376	11	(	(	-LRB-
cord-001835-0s7ok4uw	376	12	WHO	WHO	NNP
cord-001835-0s7ok4uw	376	13	Press	Press	NNP
cord-001835-0s7ok4uw	376	14	,	,	,
cord-001835-0s7ok4uw	376	15	Geneva	Geneva	NNP
cord-001835-0s7ok4uw	376	16	,	,	,
cord-001835-0s7ok4uw	376	17	Switzerland	Switzerland	NNP
cord-001835-0s7ok4uw	376	18	)	)	-RRB-
cord-001835-0s7ok4uw	376	19	,	,	,
cord-001835-0s7ok4uw	376	20	http://www	http://www	NNP
cord-001835-0s7ok4uw	376	21	.	.	.
cord-001835-0s7ok4uw	377	1	who.int/malaria/publications/world_malaria_report_2014/wmr-2014-no-profiles.pdf?ua51	who.int/malaria/publications/world_malaria_report_2014/wmr-2014-no-profiles.pdf?ua51	NNP
cord-001835-0s7ok4uw	377	2	 	 	_SP
cord-001835-0s7ok4uw	377	3	Protein	Protein	NNP
cord-001835-0s7ok4uw	377	4	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	377	5	play	play	VBP
cord-001835-0s7ok4uw	377	6	a	a	DT
cord-001835-0s7ok4uw	377	7	crucial	crucial	JJ
cord-001835-0s7ok4uw	377	8	role	role	NN
cord-001835-0s7ok4uw	377	9	in	in	IN
cord-001835-0s7ok4uw	377	10	signaling	signal	VBG
cord-001835-0s7ok4uw	377	11	pathways	pathway	NNS
cord-001835-0s7ok4uw	377	12	by	by	IN
cord-001835-0s7ok4uw	377	13	generating	generate	VBG
cord-001835-0s7ok4uw	377	14	signal	signal	NN
cord-001835-0s7ok4uw	377	15	specificity	specificity	NN
cord-001835-0s7ok4uw	377	16	and	and	CC
cord-001835-0s7ok4uw	377	17	increasing	increase	VBG
cord-001835-0s7ok4uw	377	18	signal	signal	NN
cord-001835-0s7ok4uw	377	19	efficiency	efficiency	NN
cord-001835-0s7ok4uw	377	20	and	and	CC
cord-001835-0s7ok4uw	377	21	amplitude	amplitude	NN
cord-001835-0s7ok4uw	377	22	.	.	.
cord-001835-0s7ok4uw	378	1	Engineered	engineer	VBN
cord-001835-0s7ok4uw	378	2	protein	protein	NN
cord-001835-0s7ok4uw	378	3	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	378	4	can	can	MD
cord-001835-0s7ok4uw	378	5	be	be	VB
cord-001835-0s7ok4uw	378	6	used	use	VBN
cord-001835-0s7ok4uw	378	7	as	as	IN
cord-001835-0s7ok4uw	378	8	key	key	JJ
cord-001835-0s7ok4uw	378	9	regulators	regulator	NNS
cord-001835-0s7ok4uw	378	10	for	for	IN
cord-001835-0s7ok4uw	378	11	signal	signal	NN
cord-001835-0s7ok4uw	378	12	transduction	transduction	NN
cord-001835-0s7ok4uw	378	13	in	in	IN
cord-001835-0s7ok4uw	378	14	artificial	artificial	JJ
cord-001835-0s7ok4uw	378	15	signal	signal	NN
cord-001835-0s7ok4uw	378	16	transduction	transduction	NN
cord-001835-0s7ok4uw	378	17	cascades	cascade	NNS
cord-001835-0s7ok4uw	378	18	where	where	WRB
cord-001835-0s7ok4uw	378	19	they	-PRON-	PRP
cord-001835-0s7ok4uw	378	20	can	can	MD
cord-001835-0s7ok4uw	378	21	regulate	regulate	VB
cord-001835-0s7ok4uw	378	22	in	in	IN
cord-001835-0s7ok4uw	378	23	-	-	HYPH
cord-001835-0s7ok4uw	378	24	and	and	CC
cord-001835-0s7ok4uw	378	25	output	output	NN
cord-001835-0s7ok4uw	378	26	of	of	IN
cord-001835-0s7ok4uw	378	27	the	the	DT
cord-001835-0s7ok4uw	378	28	network	network	NN
cord-001835-0s7ok4uw	378	29	.	.	.
cord-001835-0s7ok4uw	379	1	In	in	IN
cord-001835-0s7ok4uw	379	2	this	this	DT
cord-001835-0s7ok4uw	379	3	research	research	NN
cord-001835-0s7ok4uw	379	4	a	a	DT
cord-001835-0s7ok4uw	379	5	14	14	CD
cord-001835-0s7ok4uw	379	6	-	-	SYM
cord-001835-0s7ok4uw	379	7	3	3	CD
cord-001835-0s7ok4uw	379	8	-	-	SYM
cord-001835-0s7ok4uw	379	9	3	3	CD
cord-001835-0s7ok4uw	379	10	protein	protein	NN
cord-001835-0s7ok4uw	379	11	scaffold	scaffold	NN
cord-001835-0s7ok4uw	379	12	is	be	VBZ
cord-001835-0s7ok4uw	379	13	developed	develop	VBN
cord-001835-0s7ok4uw	379	14	which	which	WDT
cord-001835-0s7ok4uw	379	15	induces	induce	VBZ
cord-001835-0s7ok4uw	379	16	dimerization	dimerization	NN
cord-001835-0s7ok4uw	379	17	of	of	IN
cord-001835-0s7ok4uw	379	18	proteins	protein	NNS
cord-001835-0s7ok4uw	379	19	mediated	mediate	VBN
cord-001835-0s7ok4uw	379	20	by	by	IN
cord-001835-0s7ok4uw	379	21	the	the	DT
cord-001835-0s7ok4uw	379	22	small	small	JJ
cord-001835-0s7ok4uw	379	23	molecule	molecule	NN
cord-001835-0s7ok4uw	379	24	stabilizer	stabilizer	NN
cord-001835-0s7ok4uw	379	25	fusicoccin	fusicoccin	NNS
cord-001835-0s7ok4uw	379	26	.	.	.
cord-001835-0s7ok4uw	380	1	As	as	IN
cord-001835-0s7ok4uw	380	2	proof	proof	NN
cord-001835-0s7ok4uw	380	3	of	of	IN
cord-001835-0s7ok4uw	380	4	principle	principle	JJ
cord-001835-0s7ok4uw	380	5	caspase	caspase	NN
cord-001835-0s7ok4uw	380	6	9	9	CD
cord-001835-0s7ok4uw	380	7	is	be	VBZ
cord-001835-0s7ok4uw	380	8	used	use	VBN
cord-001835-0s7ok4uw	380	9	to	to	TO
cord-001835-0s7ok4uw	380	10	constitute	constitute	VB
cord-001835-0s7ok4uw	380	11	proximity	proximity	NN
cord-001835-0s7ok4uw	380	12	induced	induce	VBN
cord-001835-0s7ok4uw	380	13	dimerization	dimerization	NN
cord-001835-0s7ok4uw	380	14	.	.	.
cord-001835-0s7ok4uw	381	1	Dimerization	Dimerization	NNP
cord-001835-0s7ok4uw	381	2	of	of	IN
cord-001835-0s7ok4uw	381	3	caspase	caspase	NN
cord-001835-0s7ok4uw	381	4	9	9	CD
cord-001835-0s7ok4uw	381	5	leads	lead	NNS
cord-001835-0s7ok4uw	381	6	to	to	IN
cord-001835-0s7ok4uw	381	7	its	-PRON-	PRP$
cord-001835-0s7ok4uw	381	8	activation	activation	NN
cord-001835-0s7ok4uw	381	9	and	and	CC
cord-001835-0s7ok4uw	381	10	consecutively	consecutively	RB
cord-001835-0s7ok4uw	381	11	initiates	initiate	VBZ
cord-001835-0s7ok4uw	381	12	the	the	DT
cord-001835-0s7ok4uw	381	13	caspase	caspase	NN
cord-001835-0s7ok4uw	381	14	cascade	cascade	NN
cord-001835-0s7ok4uw	381	15	involved	involve	VBN
cord-001835-0s7ok4uw	381	16	in	in	IN
cord-001835-0s7ok4uw	381	17	the	the	DT
cord-001835-0s7ok4uw	381	18	programmed	programmed	JJ
cord-001835-0s7ok4uw	381	19	cell	cell	NN
cord-001835-0s7ok4uw	381	20	death	death	NN
cord-001835-0s7ok4uw	381	21	pathway	pathway	NN
cord-001835-0s7ok4uw	381	22	.	.	.
cord-001835-0s7ok4uw	382	1	Caspase	Caspase	NNP
cord-001835-0s7ok4uw	382	2	9	9	CD
cord-001835-0s7ok4uw	382	3	does	do	VBZ
cord-001835-0s7ok4uw	382	4	not	not	RB
cord-001835-0s7ok4uw	382	5	naturally	naturally	RB
cord-001835-0s7ok4uw	382	6	bind	bind	VB
cord-001835-0s7ok4uw	382	7	to	to	IN
cord-001835-0s7ok4uw	382	8	14	14	CD
cord-001835-0s7ok4uw	382	9	-	-	SYM
cord-001835-0s7ok4uw	382	10	3	3	CD
cord-001835-0s7ok4uw	382	11	-	-	SYM
cord-001835-0s7ok4uw	382	12	3	3	CD
cord-001835-0s7ok4uw	382	13	proteins	protein	NNS
cord-001835-0s7ok4uw	382	14	,	,	,
cord-001835-0s7ok4uw	382	15	therefore	therefore	RB
cord-001835-0s7ok4uw	382	16	the	the	DT
cord-001835-0s7ok4uw	382	17	caspase	caspase	NN
cord-001835-0s7ok4uw	382	18	9	9	CD
cord-001835-0s7ok4uw	382	19	monomer	monomer	NN
cord-001835-0s7ok4uw	382	20	is	be	VBZ
cord-001835-0s7ok4uw	382	21	conjugated	conjugate	VBN
cord-001835-0s7ok4uw	382	22	to	to	IN
cord-001835-0s7ok4uw	382	23	a	a	DT
cord-001835-0s7ok4uw	382	24	14	14	CD
cord-001835-0s7ok4uw	382	25	-	-	SYM
cord-001835-0s7ok4uw	382	26	3	3	CD
cord-001835-0s7ok4uw	382	27	-	-	SYM
cord-001835-0s7ok4uw	382	28	3	3	CD
cord-001835-0s7ok4uw	382	29	binding	binding	NN
cord-001835-0s7ok4uw	382	30	motif	motif	NN
cord-001835-0s7ok4uw	382	31	which	which	WDT
cord-001835-0s7ok4uw	382	32	is	be	VBZ
cord-001835-0s7ok4uw	382	33	known	know	VBN
cord-001835-0s7ok4uw	382	34	to	to	TO
cord-001835-0s7ok4uw	382	35	bind	bind	VB
cord-001835-0s7ok4uw	382	36	into	into	IN
cord-001835-0s7ok4uw	382	37	the	the	DT
cord-001835-0s7ok4uw	382	38	binding	bind	VBG
cord-001835-0s7ok4uw	382	39	grooves	groove	NNS
cord-001835-0s7ok4uw	382	40	of	of	IN
cord-001835-0s7ok4uw	382	41	a	a	DT
cord-001835-0s7ok4uw	382	42	14	14	CD
cord-001835-0s7ok4uw	382	43	-	-	SYM
cord-001835-0s7ok4uw	382	44	3	3	CD
cord-001835-0s7ok4uw	382	45	-	-	SYM
cord-001835-0s7ok4uw	382	46	3	3	CD
cord-001835-0s7ok4uw	382	47	dimer	dimer	NN
cord-001835-0s7ok4uw	382	48	.	.	.
cord-001835-0s7ok4uw	383	1	This	this	DT
cord-001835-0s7ok4uw	383	2	interaction	interaction	NN
cord-001835-0s7ok4uw	383	3	can	can	MD
cord-001835-0s7ok4uw	383	4	be	be	VB
cord-001835-0s7ok4uw	383	5	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	383	6	by	by	IN
cord-001835-0s7ok4uw	383	7	the	the	DT
cord-001835-0s7ok4uw	383	8	small	small	JJ
cord-001835-0s7ok4uw	383	9	molecule	molecule	NN
cord-001835-0s7ok4uw	383	10	fusicoccin	fusicoccin	NNS
cord-001835-0s7ok4uw	383	11	.	.	.
cord-001835-0s7ok4uw	384	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	384	2	showed	show	VBD
cord-001835-0s7ok4uw	384	3	that	that	IN
cord-001835-0s7ok4uw	384	4	upon	upon	IN
cord-001835-0s7ok4uw	384	5	addition	addition	NN
cord-001835-0s7ok4uw	384	6	of	of	IN
cord-001835-0s7ok4uw	384	7	small	small	JJ
cord-001835-0s7ok4uw	384	8	molecule	molecule	NN
cord-001835-0s7ok4uw	384	9	fusiccocin	fusiccocin	NNS
cord-001835-0s7ok4uw	384	10	caspase	caspase	NN
cord-001835-0s7ok4uw	384	11	dimerization	dimerization	NN
cord-001835-0s7ok4uw	384	12	is	be	VBZ
cord-001835-0s7ok4uw	384	13	induced	induce	VBN
cord-001835-0s7ok4uw	384	14	,	,	,
cord-001835-0s7ok4uw	384	15	resulting	result	VBG
cord-001835-0s7ok4uw	384	16	in	in	IN
cord-001835-0s7ok4uw	384	17	caspase	caspase	NN
cord-001835-0s7ok4uw	384	18	activity	activity	NN
cord-001835-0s7ok4uw	384	19	which	which	WDT
cord-001835-0s7ok4uw	384	20	is	be	VBZ
cord-001835-0s7ok4uw	384	21	measured	measure	VBN
cord-001835-0s7ok4uw	384	22	using	use	VBG
cord-001835-0s7ok4uw	384	23	a	a	DT
cord-001835-0s7ok4uw	384	24	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	384	25	caspase	caspase	NN
cord-001835-0s7ok4uw	384	26	substrate	substrate	NN
cord-001835-0s7ok4uw	384	27	.	.	.
cord-001835-0s7ok4uw	385	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	385	2	the	the	DT
cord-001835-0s7ok4uw	385	3	biphasic	biphasic	JJ
cord-001835-0s7ok4uw	385	4	effect	effect	NN
cord-001835-0s7ok4uw	385	5	of	of	IN
cord-001835-0s7ok4uw	385	6	the	the	DT
cord-001835-0s7ok4uw	385	7	14	14	CD
cord-001835-0s7ok4uw	385	8	-	-	SYM
cord-001835-0s7ok4uw	385	9	3	3	CD
cord-001835-0s7ok4uw	385	10	-	-	SYM
cord-001835-0s7ok4uw	385	11	3	3	CD
cord-001835-0s7ok4uw	385	12	scaffold	scaffold	NN
cord-001835-0s7ok4uw	385	13	could	could	MD
cord-001835-0s7ok4uw	385	14	be	be	VB
cord-001835-0s7ok4uw	385	15	proven	prove	VBN
cord-001835-0s7ok4uw	385	16	.	.	.
cord-001835-0s7ok4uw	386	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	386	2	,	,	,
cord-001835-0s7ok4uw	386	3	the	the	DT
cord-001835-0s7ok4uw	386	4	activated	activate	VBN
cord-001835-0s7ok4uw	386	5	caspase	caspase	NN
cord-001835-0s7ok4uw	386	6	9	9	CD
cord-001835-0s7ok4uw	386	7	is	be	VBZ
cord-001835-0s7ok4uw	386	8	also	also	RB
cord-001835-0s7ok4uw	386	9	able	able	JJ
cord-001835-0s7ok4uw	386	10	to	to	TO
cord-001835-0s7ok4uw	386	11	cleave	cleave	VB
cord-001835-0s7ok4uw	386	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	386	13	natural	natural	JJ
cord-001835-0s7ok4uw	386	14	substrate	substrate	NN
cord-001835-0s7ok4uw	386	15	caspase	caspase	NN
cord-001835-0s7ok4uw	386	16	3	3	CD
cord-001835-0s7ok4uw	386	17	,	,	,
cord-001835-0s7ok4uw	386	18	downstream	downstream	JJ
cord-001835-0s7ok4uw	386	19	in	in	IN
cord-001835-0s7ok4uw	386	20	the	the	DT
cord-001835-0s7ok4uw	386	21	caspase	caspase	NN
cord-001835-0s7ok4uw	386	22	cascade	cascade	NN
cord-001835-0s7ok4uw	386	23	.	.	.
cord-001835-0s7ok4uw	387	1	These	these	DT
cord-001835-0s7ok4uw	387	2	results	result	NNS
cord-001835-0s7ok4uw	387	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	387	4	that	that	IN
cord-001835-0s7ok4uw	387	5	the	the	DT
cord-001835-0s7ok4uw	387	6	14	14	CD
cord-001835-0s7ok4uw	387	7	-	-	SYM
cord-001835-0s7ok4uw	387	8	3	3	CD
cord-001835-0s7ok4uw	387	9	-	-	SYM
cord-001835-0s7ok4uw	387	10	3	3	CD
cord-001835-0s7ok4uw	387	11	platform	platform	NN
cord-001835-0s7ok4uw	387	12	is	be	VBZ
cord-001835-0s7ok4uw	387	13	a	a	DT
cord-001835-0s7ok4uw	387	14	versatile	versatile	JJ
cord-001835-0s7ok4uw	387	15	small	small	JJ
cord-001835-0s7ok4uw	387	16	molecule	molecule	NN
cord-001835-0s7ok4uw	387	17	induced	induce	VBN
cord-001835-0s7ok4uw	387	18	dimerization	dimerization	NN
cord-001835-0s7ok4uw	387	19	platform	platform	NN
cord-001835-0s7ok4uw	387	20	which	which	WDT
cord-001835-0s7ok4uw	387	21	can	can	MD
cord-001835-0s7ok4uw	387	22	be	be	VB
cord-001835-0s7ok4uw	387	23	used	use	VBN
cord-001835-0s7ok4uw	387	24	as	as	IN
cord-001835-0s7ok4uw	387	25	tool	tool	NN
cord-001835-0s7ok4uw	387	26	for	for	IN
cord-001835-0s7ok4uw	387	27	engineering	engineering	NN
cord-001835-0s7ok4uw	387	28	of	of	IN
cord-001835-0s7ok4uw	387	29	a	a	DT
cord-001835-0s7ok4uw	387	30	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	387	31	signaling	signaling	NN
cord-001835-0s7ok4uw	387	32	network	network	NN
cord-001835-0s7ok4uw	387	33	.	.	.
cord-001835-0s7ok4uw	388	1	The	the	DT
cord-001835-0s7ok4uw	388	2	G308E	G308E	NNP
cord-001835-0s7ok4uw	388	3	variant	variant	NN
cord-001835-0s7ok4uw	388	4	of	of	IN
cord-001835-0s7ok4uw	388	5	the	the	DT
cord-001835-0s7ok4uw	388	6	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	388	7	inducing	induce	VBG
cord-001835-0s7ok4uw	388	8	factor	factor	NN
cord-001835-0s7ok4uw	388	9	,	,	,
cord-001835-0s7ok4uw	388	10	responsible	responsible	JJ
cord-001835-0s7ok4uw	388	11	of	of	IN
cord-001835-0s7ok4uw	388	12	a	a	DT
cord-001835-0s7ok4uw	388	13	rare	rare	JJ
cord-001835-0s7ok4uw	388	14	encephalopathy	encephalopathy	NN
cord-001835-0s7ok4uw	388	15	,	,	,
cord-001835-0s7ok4uw	388	16	is	be	VBZ
cord-001835-0s7ok4uw	388	17	hampered	hamper	VBN
cord-001835-0s7ok4uw	388	18	in	in	IN
cord-001835-0s7ok4uw	388	19	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	388	20	/	/	SYM
cord-001835-0s7ok4uw	388	21	H	h	NN
cord-001835-0s7ok4uw	388	22	binding	bind	VBG
cord-001835-0s7ok4uw	388	23	Luca	Luca	NNP
cord-001835-0s7ok4uw	388	24	Sorrentino	Sorrentino	NNP
cord-001835-0s7ok4uw	388	25	1	1	CD
cord-001835-0s7ok4uw	388	26	,	,	,
cord-001835-0s7ok4uw	388	27	Laura	Laura	NNP
cord-001835-0s7ok4uw	388	28	Rigamonti	Rigamonti	NNP
cord-001835-0s7ok4uw	388	29	1	1	CD
cord-001835-0s7ok4uw	388	30	,	,	,
cord-001835-0s7ok4uw	388	31	Mirvan	Mirvan	NNP
cord-001835-0s7ok4uw	388	32	Krasniqi	Krasniqi	NNP
cord-001835-0s7ok4uw	388	33	1	1	CD
cord-001835-0s7ok4uw	388	34	,	,	,
cord-001835-0s7ok4uw	388	35	Alessandra	Alessandra	NNP
cord-001835-0s7ok4uw	388	36	Calogero	Calogero	NNP
cord-001835-0s7ok4uw	388	37	1	1	CD
cord-001835-0s7ok4uw	388	38	,	,	,
cord-001835-0s7ok4uw	388	39	Vittorio	Vittorio	NNP
cord-001835-0s7ok4uw	388	40	Pandini	Pandini	NNP
cord-001835-0s7ok4uw	388	41	1	1	CD
cord-001835-0s7ok4uw	388	42	,	,	,
cord-001835-0s7ok4uw	388	43	Maria	Maria	NNP
cord-001835-0s7ok4uw	388	44	Antonietta	Antonietta	NNP
cord-001835-0s7ok4uw	388	45	Vanoni	Vanoni	NNP
cord-001835-0s7ok4uw	388	46	1	1	CD
cord-001835-0s7ok4uw	388	47	,	,	,
cord-001835-0s7ok4uw	389	1	Alessandro	Alessandro	NNP
cord-001835-0s7ok4uw	389	2	Aliverti	Aliverti	NNP
cord-001835-0s7ok4uw	389	3	1	1	CD
cord-001835-0s7ok4uw	389	4	1	1	CD
cord-001835-0s7ok4uw	389	5	The	the	DT
cord-001835-0s7ok4uw	389	6	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	389	7	inducing	induce	VBG
cord-001835-0s7ok4uw	389	8	factor	factor	NN
cord-001835-0s7ok4uw	389	9	(	(	-LRB-
cord-001835-0s7ok4uw	389	10	AIF	AIF	NNP
cord-001835-0s7ok4uw	389	11	)	)	-RRB-
cord-001835-0s7ok4uw	389	12	is	be	VBZ
cord-001835-0s7ok4uw	389	13	a	a	DT
cord-001835-0s7ok4uw	389	14	highly	highly	RB
cord-001835-0s7ok4uw	389	15	conserved	conserve	VBN
cord-001835-0s7ok4uw	389	16	mitochondrial	mitochondrial	NN
cord-001835-0s7ok4uw	389	17	flavoprotein	flavoprotein	NNP
cord-001835-0s7ok4uw	389	18	known	know	VBN
cord-001835-0s7ok4uw	389	19	to	to	TO
cord-001835-0s7ok4uw	389	20	play	play	VB
cord-001835-0s7ok4uw	389	21	two	two	CD
cord-001835-0s7ok4uw	389	22	opposite	opposite	JJ
cord-001835-0s7ok4uw	389	23	roles	role	NNS
cord-001835-0s7ok4uw	389	24	in	in	IN
cord-001835-0s7ok4uw	389	25	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	389	26	cells	cell	NNS
cord-001835-0s7ok4uw	389	27	:	:	:
cord-001835-0s7ok4uw	389	28	in	in	IN
cord-001835-0s7ok4uw	389	29	mitochondria	mitochondrion	NNS
cord-001835-0s7ok4uw	389	30	it	-PRON-	PRP
cord-001835-0s7ok4uw	389	31	is	be	VBZ
cord-001835-0s7ok4uw	389	32	required	require	VBN
cord-001835-0s7ok4uw	389	33	for	for	IN
cord-001835-0s7ok4uw	389	34	efficient	efficient	JJ
cord-001835-0s7ok4uw	389	35	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	389	36	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	389	37	(	(	-LRB-
cord-001835-0s7ok4uw	389	38	OXPHOS	OXPHOS	NNP
cord-001835-0s7ok4uw	389	39	)	)	-RRB-
cord-001835-0s7ok4uw	389	40	,	,	,
cord-001835-0s7ok4uw	389	41	while	while	IN
cord-001835-0s7ok4uw	389	42	,	,	,
cord-001835-0s7ok4uw	389	43	when	when	WRB
cord-001835-0s7ok4uw	389	44	released	release	VBN
cord-001835-0s7ok4uw	389	45	into	into	IN
cord-001835-0s7ok4uw	389	46	the	the	DT
cord-001835-0s7ok4uw	389	47	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	389	48	,	,	,
cord-001835-0s7ok4uw	389	49	it	-PRON-	PRP
cord-001835-0s7ok4uw	389	50	triggers	trigger	VBZ
cord-001835-0s7ok4uw	389	51	caspase	caspase	NN
cord-001835-0s7ok4uw	389	52	-	-	HYPH
cord-001835-0s7ok4uw	389	53	independent	independent	JJ
cord-001835-0s7ok4uw	389	54	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	389	55	(	(	-LRB-
cord-001835-0s7ok4uw	389	56	1	1	CD
cord-001835-0s7ok4uw	389	57	)	)	-RRB-
cord-001835-0s7ok4uw	389	58	.	.	.
cord-001835-0s7ok4uw	390	1	The	the	DT
cord-001835-0s7ok4uw	390	2	mechanism	mechanism	NN
cord-001835-0s7ok4uw	390	3	of	of	IN
cord-001835-0s7ok4uw	390	4	AIF	aif	NN
cord-001835-0s7ok4uw	390	5	-	-	HYPH
cord-001835-0s7ok4uw	390	6	induced	induce	VBN
cord-001835-0s7ok4uw	390	7	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	390	8	was	be	VBD
cord-001835-0s7ok4uw	390	9	extensively	extensively	RB
cord-001835-0s7ok4uw	390	10	investigated	investigate	VBN
cord-001835-0s7ok4uw	390	11	,	,	,
cord-001835-0s7ok4uw	390	12	whereas	whereas	IN
cord-001835-0s7ok4uw	390	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	390	14	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	390	15	role	role	NN
cord-001835-0s7ok4uw	390	16	is	be	VBZ
cord-001835-0s7ok4uw	390	17	poorly	poorly	RB
cord-001835-0s7ok4uw	390	18	understood	understand	VBN
cord-001835-0s7ok4uw	390	19	.	.	.
cord-001835-0s7ok4uw	391	1	There	there	EX
cord-001835-0s7ok4uw	391	2	are	be	VBP
cord-001835-0s7ok4uw	391	3	many	many	JJ
cord-001835-0s7ok4uw	391	4	evidences	evidence	NNS
cord-001835-0s7ok4uw	391	5	of	of	IN
cord-001835-0s7ok4uw	391	6	AIF	AIF	NNP
cord-001835-0s7ok4uw	391	7	importance	importance	NN
cord-001835-0s7ok4uw	391	8	for	for	IN
cord-001835-0s7ok4uw	391	9	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	391	10	correct	correct	JJ
cord-001835-0s7ok4uw	391	11	morphology	morphology	NN
cord-001835-0s7ok4uw	391	12	and	and	CC
cord-001835-0s7ok4uw	391	13	functions	function	NNS
cord-001835-0s7ok4uw	391	14	and	and	CC
cord-001835-0s7ok4uw	391	15	recently	recently	RB
cord-001835-0s7ok4uw	391	16	the	the	DT
cord-001835-0s7ok4uw	391	17	discovery	discovery	NN
cord-001835-0s7ok4uw	391	18	of	of	IN
cord-001835-0s7ok4uw	391	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	391	20	direct	direct	JJ
cord-001835-0s7ok4uw	391	21	interaction	interaction	NN
cord-001835-0s7ok4uw	391	22	with	with	IN
cord-001835-0s7ok4uw	391	23	CHCHD4	CHCHD4	NNP
cord-001835-0s7ok4uw	391	24	,	,	,
cord-001835-0s7ok4uw	391	25	a	a	DT
cord-001835-0s7ok4uw	391	26	key	key	JJ
cord-001835-0s7ok4uw	391	27	regulator	regulator	NN
cord-001835-0s7ok4uw	391	28	of	of	IN
cord-001835-0s7ok4uw	391	29	respiratory	respiratory	JJ
cord-001835-0s7ok4uw	391	30	complexes	complex	NNS
cord-001835-0s7ok4uw	391	31	subunits	subunit	NNS
cord-001835-0s7ok4uw	391	32	import	import	NN
cord-001835-0s7ok4uw	391	33	and	and	CC
cord-001835-0s7ok4uw	391	34	folding	fold	VBG
cord-001835-0s7ok4uw	391	35	in	in	IN
cord-001835-0s7ok4uw	391	36	mitochondria	mitochondrion	NNS
cord-001835-0s7ok4uw	391	37	,	,	,
cord-001835-0s7ok4uw	391	38	was	be	VBD
cord-001835-0s7ok4uw	391	39	reported	report	VBN
cord-001835-0s7ok4uw	391	40	(	(	-LRB-
cord-001835-0s7ok4uw	391	41	2	2	CD
cord-001835-0s7ok4uw	391	42	)	)	-RRB-
cord-001835-0s7ok4uw	391	43	.	.	.
cord-001835-0s7ok4uw	392	1	A	a	DT
cord-001835-0s7ok4uw	392	2	unique	unique	JJ
cord-001835-0s7ok4uw	392	3	feature	feature	NN
cord-001835-0s7ok4uw	392	4	of	of	IN
cord-001835-0s7ok4uw	392	5	AIF	AIF	NNP
cord-001835-0s7ok4uw	392	6	,	,	,
cord-001835-0s7ok4uw	392	7	probably	probably	RB
cord-001835-0s7ok4uw	392	8	pivotal	pivotal	JJ
cord-001835-0s7ok4uw	392	9	for	for	IN
cord-001835-0s7ok4uw	392	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	392	11	vital	vital	JJ
cord-001835-0s7ok4uw	392	12	function	function	NN
cord-001835-0s7ok4uw	392	13	,	,	,
cord-001835-0s7ok4uw	392	14	is	be	VBZ
cord-001835-0s7ok4uw	392	15	the	the	DT
cord-001835-0s7ok4uw	392	16	ability	ability	NN
cord-001835-0s7ok4uw	392	17	to	to	TO
cord-001835-0s7ok4uw	392	18	form	form	VB
cord-001835-0s7ok4uw	392	19	a	a	DT
cord-001835-0s7ok4uw	392	20	tight	tight	JJ
cord-001835-0s7ok4uw	392	21	,	,	,
cord-001835-0s7ok4uw	392	22	air	air	NN
cord-001835-0s7ok4uw	392	23	-	-	HYPH
cord-001835-0s7ok4uw	392	24	stable	stable	JJ
cord-001835-0s7ok4uw	392	25	charge	charge	NN
cord-001835-0s7ok4uw	392	26	-	-	HYPH
cord-001835-0s7ok4uw	392	27	transfer	transfer	NN
cord-001835-0s7ok4uw	392	28	(	(	-LRB-
cord-001835-0s7ok4uw	392	29	CT	CT	NNP
cord-001835-0s7ok4uw	392	30	)	)	-RRB-
cord-001835-0s7ok4uw	392	31	complex	complex	NN
cord-001835-0s7ok4uw	392	32	with	with	IN
cord-001835-0s7ok4uw	392	33	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	392	34	and	and	CC
cord-001835-0s7ok4uw	392	35	undergo	undergo	VB
cord-001835-0s7ok4uw	392	36	dimerization	dimerization	NN
cord-001835-0s7ok4uw	392	37	.	.	.
cord-001835-0s7ok4uw	393	1	Although	although	IN
cord-001835-0s7ok4uw	393	2	some	some	DT
cord-001835-0s7ok4uw	393	3	aspects	aspect	NNS
cord-001835-0s7ok4uw	393	4	of	of	IN
cord-001835-0s7ok4uw	393	5	AIF	AIF	NNP
cord-001835-0s7ok4uw	393	6	interaction	interaction	NN
cord-001835-0s7ok4uw	393	7	with	with	IN
cord-001835-0s7ok4uw	393	8	NAD1/	NAD1/	NNP
cord-001835-0s7ok4uw	393	9	H	H	NNP
cord-001835-0s7ok4uw	393	10	have	have	VBP
cord-001835-0s7ok4uw	393	11	been	be	VBN
cord-001835-0s7ok4uw	393	12	analyzed	analyze	VBN
cord-001835-0s7ok4uw	393	13	,	,	,
cord-001835-0s7ok4uw	393	14	its	-PRON-	PRP$
cord-001835-0s7ok4uw	393	15	precise	precise	JJ
cord-001835-0s7ok4uw	393	16	mechanism	mechanism	NN
cord-001835-0s7ok4uw	393	17	is	be	VBZ
cord-001835-0s7ok4uw	393	18	not	not	RB
cord-001835-0s7ok4uw	393	19	fully	fully	RB
cord-001835-0s7ok4uw	393	20	understood	understand	VBN
cord-001835-0s7ok4uw	393	21	.	.	.
cord-001835-0s7ok4uw	394	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	394	2	investigated	investigate	VBD
cord-001835-0s7ok4uw	394	3	the	the	DT
cord-001835-0s7ok4uw	394	4	effect	effect	NN
cord-001835-0s7ok4uw	394	5	of	of	IN
cord-001835-0s7ok4uw	394	6	the	the	DT
cord-001835-0s7ok4uw	394	7	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	394	8	G308E	G308E	NNP
cord-001835-0s7ok4uw	394	9	replacement	replacement	NN
cord-001835-0s7ok4uw	394	10	,	,	,
cord-001835-0s7ok4uw	394	11	associated	associate	VBN
cord-001835-0s7ok4uw	394	12	with	with	IN
cord-001835-0s7ok4uw	394	13	OXPHOS	OXPHOS	NNP
cord-001835-0s7ok4uw	394	14	defect	defect	NN
cord-001835-0s7ok4uw	394	15	and	and	CC
cord-001835-0s7ok4uw	394	16	neurodegeneration	neurodegeneration	NN
cord-001835-0s7ok4uw	394	17	(	(	-LRB-
cord-001835-0s7ok4uw	394	18	3	3	CD
cord-001835-0s7ok4uw	394	19	)	)	-RRB-
cord-001835-0s7ok4uw	394	20	,	,	,
cord-001835-0s7ok4uw	394	21	to	to	TO
cord-001835-0s7ok4uw	394	22	understand	understand	VB
cord-001835-0s7ok4uw	394	23	how	how	WRB
cord-001835-0s7ok4uw	394	24	it	-PRON-	PRP
cord-001835-0s7ok4uw	394	25	could	could	MD
cord-001835-0s7ok4uw	394	26	alter	alter	VB
cord-001835-0s7ok4uw	394	27	AIF	AIF	NNP
cord-001835-0s7ok4uw	394	28	properties	property	NNS
cord-001835-0s7ok4uw	394	29	at	at	IN
cord-001835-0s7ok4uw	394	30	the	the	DT
cord-001835-0s7ok4uw	394	31	molecular	molecular	JJ
cord-001835-0s7ok4uw	394	32	level	level	NN
cord-001835-0s7ok4uw	394	33	.	.	.
cord-001835-0s7ok4uw	395	1	To	to	TO
cord-001835-0s7ok4uw	395	2	do	do	VB
cord-001835-0s7ok4uw	395	3	so	so	RB
cord-001835-0s7ok4uw	395	4	,	,	,
cord-001835-0s7ok4uw	395	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	395	6	analysed	analyse	VBD
cord-001835-0s7ok4uw	395	7	how	how	WRB
cord-001835-0s7ok4uw	395	8	the	the	DT
cord-001835-0s7ok4uw	395	9	wild	wild	JJ
cord-001835-0s7ok4uw	395	10	type	type	NN
cord-001835-0s7ok4uw	395	11	and	and	CC
cord-001835-0s7ok4uw	395	12	the	the	DT
cord-001835-0s7ok4uw	395	13	G307E	G307E	NNP
cord-001835-0s7ok4uw	395	14	forms	form	NNS
cord-001835-0s7ok4uw	395	15	of	of	IN
cord-001835-0s7ok4uw	395	16	murine	murine	JJ
cord-001835-0s7ok4uw	395	17	AIF	AIF	NNP
cord-001835-0s7ok4uw	395	18	interact	interact	VBP
cord-001835-0s7ok4uw	395	19	with	with	IN
cord-001835-0s7ok4uw	395	20	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	395	21	/	/	SYM
cord-001835-0s7ok4uw	395	22	H	h	NN
cord-001835-0s7ok4uw	395	23	and	and	CC
cord-001835-0s7ok4uw	395	24	nicotinamide	nicotinamide	NN
cord-001835-0s7ok4uw	395	25	mononucleotide	mononucleotide	NNP
cord-001835-0s7ok4uw	395	26	(	(	-LRB-
cord-001835-0s7ok4uw	395	27	NMN1/	NMN1/	NNP
cord-001835-0s7ok4uw	395	28	H	H	NNP
cord-001835-0s7ok4uw	395	29	)	)	-RRB-
cord-001835-0s7ok4uw	395	30	,	,	,
cord-001835-0s7ok4uw	395	31	finding	find	VBG
cord-001835-0s7ok4uw	395	32	that	that	IN
cord-001835-0s7ok4uw	395	33	the	the	DT
cord-001835-0s7ok4uw	395	34	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	395	35	replacement	replacement	NN
cord-001835-0s7ok4uw	395	36	resulted	result	VBD
cord-001835-0s7ok4uw	395	37	in	in	IN
cord-001835-0s7ok4uw	395	38	a	a	DT
cord-001835-0s7ok4uw	395	39	dramatic	dramatic	JJ
cord-001835-0s7ok4uw	395	40	and	and	CC
cord-001835-0s7ok4uw	395	41	specific	specific	JJ
cord-001835-0s7ok4uw	395	42	decrease	decrease	NN
cord-001835-0s7ok4uw	395	43	of	of	IN
cord-001835-0s7ok4uw	395	44	the	the	DT
cord-001835-0s7ok4uw	395	45	rate	rate	NN
cord-001835-0s7ok4uw	395	46	for	for	IN
cord-001835-0s7ok4uw	395	47	CT	CT	NNP
cord-001835-0s7ok4uw	395	48	complex	complex	JJ
cord-001835-0s7ok4uw	395	49	formation	formation	NN
cord-001835-0s7ok4uw	395	50	and	and	CC
cord-001835-0s7ok4uw	395	51	consequent	consequent	JJ
cord-001835-0s7ok4uw	395	52	protein	protein	NN
cord-001835-0s7ok4uw	395	53	dimerization	dimerization	NN
cord-001835-0s7ok4uw	395	54	only	only	RB
cord-001835-0s7ok4uw	395	55	in	in	IN
cord-001835-0s7ok4uw	395	56	the	the	DT
cord-001835-0s7ok4uw	395	57	case	case	NN
cord-001835-0s7ok4uw	395	58	of	of	IN
cord-001835-0s7ok4uw	395	59	the	the	DT
cord-001835-0s7ok4uw	395	60	physiological	physiological	JJ
cord-001835-0s7ok4uw	395	61	ligand	ligand	NN
cord-001835-0s7ok4uw	395	62	.	.	.
cord-001835-0s7ok4uw	396	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	396	2	results	result	NNS
cord-001835-0s7ok4uw	396	3	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	396	4	that	that	IN
cord-001835-0s7ok4uw	396	5	the	the	DT
cord-001835-0s7ok4uw	396	6	adenylate	adenylate	NN
cord-001835-0s7ok4uw	396	7	moiety	moiety	NN
cord-001835-0s7ok4uw	396	8	of	of	IN
cord-001835-0s7ok4uw	396	9	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	396	10	/	/	SYM
cord-001835-0s7ok4uw	396	11	H	H	NNP
cord-001835-0s7ok4uw	396	12	is	be	VBZ
cord-001835-0s7ok4uw	396	13	crucial	crucial	JJ
cord-001835-0s7ok4uw	396	14	for	for	IN
cord-001835-0s7ok4uw	396	15	the	the	DT
cord-001835-0s7ok4uw	396	16	ligand	ligand	NN
cord-001835-0s7ok4uw	396	17	binding	binding	NN
cord-001835-0s7ok4uw	396	18	process	process	NN
cord-001835-0s7ok4uw	396	19	and	and	CC
cord-001835-0s7ok4uw	396	20	that	that	IN
cord-001835-0s7ok4uw	396	21	the	the	DT
cord-001835-0s7ok4uw	396	22	G307E	G307E	NNP
cord-001835-0s7ok4uw	396	23	replacement	replacement	NN
cord-001835-0s7ok4uw	396	24	causes	cause	VBZ
cord-001835-0s7ok4uw	396	25	an	an	DT
cord-001835-0s7ok4uw	396	26	alteration	alteration	NN
cord-001835-0s7ok4uw	396	27	of	of	IN
cord-001835-0s7ok4uw	396	28	the	the	DT
cord-001835-0s7ok4uw	396	29	adenylate	adenylate	NN
cord-001835-0s7ok4uw	396	30	-	-	HYPH
cord-001835-0s7ok4uw	396	31	binding	bind	VBG
cord-001835-0s7ok4uw	396	32	site	site	NN
cord-001835-0s7ok4uw	396	33	of	of	IN
cord-001835-0s7ok4uw	396	34	AIF	AIF	NNP
cord-001835-0s7ok4uw	396	35	that	that	WDT
cord-001835-0s7ok4uw	396	36	drastically	drastically	RB
cord-001835-0s7ok4uw	396	37	decreases	decrease	VBZ
cord-001835-0s7ok4uw	396	38	the	the	DT
cord-001835-0s7ok4uw	396	39	affinity	affinity	NN
cord-001835-0s7ok4uw	396	40	for	for	IN
cord-001835-0s7ok4uw	396	41	and	and	CC
cord-001835-0s7ok4uw	396	42	the	the	DT
cord-001835-0s7ok4uw	396	43	association	association	NN
cord-001835-0s7ok4uw	396	44	rate	rate	NN
cord-001835-0s7ok4uw	396	45	of	of	IN
cord-001835-0s7ok4uw	396	46	the	the	DT
cord-001835-0s7ok4uw	396	47	ligand	ligand	NN
cord-001835-0s7ok4uw	396	48	.	.	.
cord-001835-0s7ok4uw	397	1	In	in	IN
cord-001835-0s7ok4uw	397	2	addition	addition	NN
cord-001835-0s7ok4uw	397	3	,	,	,
cord-001835-0s7ok4uw	397	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	397	5	shed	shed	VBP
cord-001835-0s7ok4uw	397	6	new	new	JJ
cord-001835-0s7ok4uw	397	7	light	light	NN
cord-001835-0s7ok4uw	397	8	on	on	IN
cord-001835-0s7ok4uw	397	9	the	the	DT
cord-001835-0s7ok4uw	397	10	mechanism	mechanism	NN
cord-001835-0s7ok4uw	397	11	of	of	IN
cord-001835-0s7ok4uw	397	12	the	the	DT
cord-001835-0s7ok4uw	397	13	dimerization	dimerization	NN
cord-001835-0s7ok4uw	397	14	process	process	NN
cord-001835-0s7ok4uw	397	15	,	,	,
cord-001835-0s7ok4uw	397	16	demonstrating	demonstrate	VBG
cord-001835-0s7ok4uw	397	17	that	that	IN
cord-001835-0s7ok4uw	397	18	FAD	fad	NN
cord-001835-0s7ok4uw	397	19	reduction	reduction	NN
cord-001835-0s7ok4uw	397	20	rather	rather	RB
cord-001835-0s7ok4uw	397	21	than	than	IN
cord-001835-0s7ok4uw	398	1	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	398	2	/	/	SYM
cord-001835-0s7ok4uw	398	3	H	h	NN
cord-001835-0s7ok4uw	398	4	binding	binding	NN
cord-001835-0s7ok4uw	398	5	initiates	initiate	VBZ
cord-001835-0s7ok4uw	398	6	the	the	DT
cord-001835-0s7ok4uw	398	7	conformational	conformational	JJ
cord-001835-0s7ok4uw	398	8	rearrangement	rearrangement	NN
cord-001835-0s7ok4uw	398	9	of	of	IN
cord-001835-0s7ok4uw	398	10	AIF	AIF	NNP
cord-001835-0s7ok4uw	398	11	that	that	WDT
cord-001835-0s7ok4uw	398	12	leads	lead	VBZ
cord-001835-0s7ok4uw	398	13	to	to	IN
cord-001835-0s7ok4uw	398	14	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	398	15	structure	structure	NN
cord-001835-0s7ok4uw	398	16	transitions	transition	NNS
cord-001835-0s7ok4uw	398	17	.	.	.
cord-001835-0s7ok4uw	399	1	Taken	take	VBN
cord-001835-0s7ok4uw	399	2	together	together	RB
cord-001835-0s7ok4uw	399	3	,	,	,
cord-001835-0s7ok4uw	399	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	399	5	results	result	NNS
cord-001835-0s7ok4uw	399	6	contribute	contribute	VBP
cord-001835-0s7ok4uw	399	7	to	to	TO
cord-001835-0s7ok4uw	399	8	define	define	VB
cord-001835-0s7ok4uw	399	9	how	how	WRB
cord-001835-0s7ok4uw	399	10	AIF	AIF	NNP
cord-001835-0s7ok4uw	399	11	works	work	VBZ
cord-001835-0s7ok4uw	399	12	at	at	IN
cord-001835-0s7ok4uw	399	13	the	the	DT
cord-001835-0s7ok4uw	399	14	molecular	molecular	JJ
cord-001835-0s7ok4uw	399	15	level	level	NN
cord-001835-0s7ok4uw	399	16	in	in	IN
cord-001835-0s7ok4uw	399	17	binding	bind	VBG
cord-001835-0s7ok4uw	399	18	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	399	19	/	/	SYM
cord-001835-0s7ok4uw	399	20	H	h	NN
cord-001835-0s7ok4uw	399	21	and	and	CC
cord-001835-0s7ok4uw	399	22	undergoing	undergo	VBG
cord-001835-0s7ok4uw	399	23	dimerization	dimerization	NN
cord-001835-0s7ok4uw	399	24	and	and	CC
cord-001835-0s7ok4uw	399	25	also	also	RB
cord-001835-0s7ok4uw	399	26	point	point	VB
cord-001835-0s7ok4uw	399	27	out	out	RP
cord-001835-0s7ok4uw	399	28	that	that	IN
cord-001835-0s7ok4uw	399	29	the	the	DT
cord-001835-0s7ok4uw	399	30	G308E	G308E	NNP
cord-001835-0s7ok4uw	399	31	replacement	replacement	NN
cord-001835-0s7ok4uw	399	32	,	,	,
cord-001835-0s7ok4uw	399	33	responsible	responsible	JJ
cord-001835-0s7ok4uw	399	34	of	of	IN
cord-001835-0s7ok4uw	399	35	a	a	DT
cord-001835-0s7ok4uw	399	36	rare	rare	JJ
cord-001835-0s7ok4uw	399	37	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	399	38	disease	disease	NN
cord-001835-0s7ok4uw	399	39	,	,	,
cord-001835-0s7ok4uw	399	40	has	have	VBZ
cord-001835-0s7ok4uw	399	41	the	the	DT
cord-001835-0s7ok4uw	399	42	selective	selective	JJ
cord-001835-0s7ok4uw	399	43	effect	effect	NN
cord-001835-0s7ok4uw	399	44	of	of	IN
cord-001835-0s7ok4uw	399	45	slowing	slow	VBG
cord-001835-0s7ok4uw	399	46	down	down	IN
cord-001835-0s7ok4uw	399	47	the	the	DT
cord-001835-0s7ok4uw	399	48	formation	formation	NN
cord-001835-0s7ok4uw	399	49	of	of	IN
cord-001835-0s7ok4uw	399	50	AIF	AIF	NNP
cord-001835-0s7ok4uw	399	51	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	399	52	CT	CT	NNP
cord-001835-0s7ok4uw	399	53	complex	complex	NN
cord-001835-0s7ok4uw	399	54	.	.	.
cord-001835-0s7ok4uw	400	1	Dipartimento	Dipartimento	NNP
cord-001835-0s7ok4uw	400	2	di	di	NNP
cord-001835-0s7ok4uw	400	3	Bioscienze	Bioscienze	NNP
cord-001835-0s7ok4uw	400	4	,	,	,
cord-001835-0s7ok4uw	400	5	Universit	Universit	NNP
cord-001835-0s7ok4uw	400	6	a	a	DT
cord-001835-0s7ok4uw	400	7	degli	degli	NN
cord-001835-0s7ok4uw	400	8	Studi	Studi	NNP
cord-001835-0s7ok4uw	400	9	di	di	FW
cord-001835-0s7ok4uw	400	10	Milano	Milano	NNP
cord-001835-0s7ok4uw	400	11	,	,	,
cord-001835-0s7ok4uw	401	1	2	2	LS
cord-001835-0s7ok4uw	401	2	Dipartimento	Dipartimento	NNP
cord-001835-0s7ok4uw	402	1	di	di	NNP
cord-001835-0s7ok4uw	403	1	Scienze	Scienze	NNP
cord-001835-0s7ok4uw	404	1	Veterinarie	Veterinarie	NNP
cord-001835-0s7ok4uw	405	1	e	e	LS
cord-001835-0s7ok4uw	405	2	Sanit	Sanit	NNP
cord-001835-0s7ok4uw	405	3	a	a	DT
cord-001835-0s7ok4uw	405	4	Pubblica	Pubblica	NNP
cord-001835-0s7ok4uw	405	5	,	,	,
cord-001835-0s7ok4uw	406	1	Universit	Universit	NNP
cord-001835-0s7ok4uw	406	2	a	a	DT
cord-001835-0s7ok4uw	406	3	degli	degli	NN
cord-001835-0s7ok4uw	406	4	Studi	Studi	NNP
cord-001835-0s7ok4uw	406	5	di	di	FW
cord-001835-0s7ok4uw	406	6	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	406	7	,	,	,
cord-001835-0s7ok4uw	406	8	from	from	IN
cord-001835-0s7ok4uw	406	9	the	the	DT
cord-001835-0s7ok4uw	406	10	Molecule	molecule	NN
cord-001835-0s7ok4uw	406	11	Interacting	interact	VBG
cord-001835-0s7ok4uw	406	12	with	with	IN
cord-001835-0s7ok4uw	406	13	CasL	CasL	NNP
cord-001835-0s7ok4uw	406	14	,	,	,
cord-001835-0s7ok4uw	406	15	indicates	indicate	VBZ
cord-001835-0s7ok4uw	406	16	a	a	DT
cord-001835-0s7ok4uw	406	17	family	family	NN
cord-001835-0s7ok4uw	406	18	of	of	IN
cord-001835-0s7ok4uw	406	19	conserved	conserved	JJ
cord-001835-0s7ok4uw	406	20	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	406	21	multidomain	multidomain	NN
cord-001835-0s7ok4uw	406	22	proteins	protein	NNS
cord-001835-0s7ok4uw	406	23	that	that	WDT
cord-001835-0s7ok4uw	406	24	catalyze	catalyze	VBP
cord-001835-0s7ok4uw	406	25	a	a	DT
cord-001835-0s7ok4uw	406	26	NADPH	nadph	NN
cord-001835-0s7ok4uw	406	27	-	-	HYPH
cord-001835-0s7ok4uw	406	28	dependent	dependent	JJ
cord-001835-0s7ok4uw	406	29	F	F	NNP
cord-001835-0s7ok4uw	406	30	-	-	HYPH
cord-001835-0s7ok4uw	406	31	actin	actin	JJ
cord-001835-0s7ok4uw	406	32	depolymerization	depolymerization	NN
cord-001835-0s7ok4uw	406	33	activity	activity	NN
cord-001835-0s7ok4uw	406	34	through	through	IN
cord-001835-0s7ok4uw	406	35	their	-PRON-	PRP$
cord-001835-0s7ok4uw	406	36	essential	essential	JJ
cord-001835-0s7ok4uw	406	37	N	n	CD
cord-001835-0s7ok4uw	406	38	-	-	HYPH
cord-001835-0s7ok4uw	406	39	terminal	terminal	NN
cord-001835-0s7ok4uw	406	40	FAD	fad	NN
cord-001835-0s7ok4uw	406	41	-	-	HYPH
cord-001835-0s7ok4uw	406	42	containing	contain	VBG
cord-001835-0s7ok4uw	406	43	monooxygenase	monooxygenase	NN
cord-001835-0s7ok4uw	406	44	-	-	HYPH
cord-001835-0s7ok4uw	406	45	like	like	JJ
cord-001835-0s7ok4uw	406	46	domain	domain	NN
cord-001835-0s7ok4uw	406	47	(	(	-LRB-
cord-001835-0s7ok4uw	406	48	MO	MO	NNP
cord-001835-0s7ok4uw	406	49	)	)	-RRB-
cord-001835-0s7ok4uw	406	50	in	in	IN
cord-001835-0s7ok4uw	406	51	response	response	NN
cord-001835-0s7ok4uw	406	52	to	to	IN
cord-001835-0s7ok4uw	406	53	semaphorin	semaphorin	NNP
cord-001835-0s7ok4uw	406	54	signaling	signal	VBG
cord-001835-0s7ok4uw	406	55	[	[	-LRB-
cord-001835-0s7ok4uw	406	56	1	1	CD
cord-001835-0s7ok4uw	406	57	]	]	-RRB-
cord-001835-0s7ok4uw	406	58	.	.	.
cord-001835-0s7ok4uw	407	1	This	this	DT
cord-001835-0s7ok4uw	407	2	domain	domain	NN
cord-001835-0s7ok4uw	407	3	is	be	VBZ
cord-001835-0s7ok4uw	407	4	followed	follow	VBN
cord-001835-0s7ok4uw	407	5	by	by	IN
cord-001835-0s7ok4uw	407	6	calponin	calponin	NN
cord-001835-0s7ok4uw	407	7	homology	homology	NN
cord-001835-0s7ok4uw	407	8	(	(	-LRB-
cord-001835-0s7ok4uw	407	9	CH	CH	NNP
cord-001835-0s7ok4uw	407	10	)	)	-RRB-
cord-001835-0s7ok4uw	407	11	and	and	CC
cord-001835-0s7ok4uw	407	12	LIM	LIM	NNP
cord-001835-0s7ok4uw	407	13	domains	domain	NNS
cord-001835-0s7ok4uw	407	14	,	,	,
cord-001835-0s7ok4uw	407	15	proline	proline	NN
cord-001835-0s7ok4uw	407	16	-	-	HYPH
cord-001835-0s7ok4uw	407	17	and	and	CC
cord-001835-0s7ok4uw	407	18	glutamate	glutamate	NN
cord-001835-0s7ok4uw	407	19	-	-	HYPH
cord-001835-0s7ok4uw	407	20	rich	rich	JJ
cord-001835-0s7ok4uw	407	21	regions	region	NNS
cord-001835-0s7ok4uw	407	22	and	and	CC
cord-001835-0s7ok4uw	407	23	a	a	DT
cord-001835-0s7ok4uw	407	24	C	c	NN
cord-001835-0s7ok4uw	407	25	-	-	HYPH
cord-001835-0s7ok4uw	407	26	terminal	terminal	NN
cord-001835-0s7ok4uw	407	27	coiled	coil	VBN
cord-001835-0s7ok4uw	407	28	-	-	HYPH
cord-001835-0s7ok4uw	407	29	coil	coil	NN
cord-001835-0s7ok4uw	407	30	motif	motif	NN
cord-001835-0s7ok4uw	407	31	that	that	WDT
cord-001835-0s7ok4uw	407	32	mediate	mediate	VBP
cord-001835-0s7ok4uw	407	33	the	the	DT
cord-001835-0s7ok4uw	407	34	interaction	interaction	NN
cord-001835-0s7ok4uw	407	35	with	with	IN
cord-001835-0s7ok4uw	407	36	various	various	JJ
cord-001835-0s7ok4uw	407	37	proteins	protein	NNS
cord-001835-0s7ok4uw	407	38	(	(	-LRB-
cord-001835-0s7ok4uw	407	39	e.g	e.g	VBZ
cord-001835-0s7ok4uw	407	40	:	:	:
cord-001835-0s7ok4uw	407	41	CRMP	CRMP	NNP
cord-001835-0s7ok4uw	407	42	,	,	,
cord-001835-0s7ok4uw	407	43	CasL	CasL	NNP
cord-001835-0s7ok4uw	407	44	,	,	,
cord-001835-0s7ok4uw	407	45	Plexin	Plexin	NNP
cord-001835-0s7ok4uw	407	46	,	,	,
cord-001835-0s7ok4uw	407	47	G	g	NN
cord-001835-0s7ok4uw	407	48	proteins	protein	NNS
cord-001835-0s7ok4uw	407	49	,	,	,
cord-001835-0s7ok4uw	407	50	NDR	NDR	NNP
cord-001835-0s7ok4uw	407	51	)	)	-RRB-
cord-001835-0s7ok4uw	407	52	[	[	-LRB-
cord-001835-0s7ok4uw	407	53	1	1	CD
cord-001835-0s7ok4uw	407	54	]	]	-RRB-
cord-001835-0s7ok4uw	407	55	.	.	.
cord-001835-0s7ok4uw	408	1	To	to	TO
cord-001835-0s7ok4uw	408	2	contribute	contribute	VB
cord-001835-0s7ok4uw	408	3	to	to	TO
cord-001835-0s7ok4uw	408	4	establish	establish	VB
cord-001835-0s7ok4uw	408	5	the	the	DT
cord-001835-0s7ok4uw	408	6	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	408	7	properties	property	NNS
cord-001835-0s7ok4uw	408	8	of	of	IN
cord-001835-0s7ok4uw	408	9	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	408	10	MO	MO	NNP
cord-001835-0s7ok4uw	408	11	and	and	CC
cord-001835-0s7ok4uw	408	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	408	13	modulation	modulation	NN
cord-001835-0s7ok4uw	408	14	by	by	IN
cord-001835-0s7ok4uw	408	15	the	the	DT
cord-001835-0s7ok4uw	408	16	additional	additional	JJ
cord-001835-0s7ok4uw	408	17	domains	domain	NNS
cord-001835-0s7ok4uw	408	18	and	and	CC
cord-001835-0s7ok4uw	408	19	by	by	IN
cord-001835-0s7ok4uw	408	20	the	the	DT
cord-001835-0s7ok4uw	408	21	interacting	interact	VBG
cord-001835-0s7ok4uw	408	22	proteins	protein	NNS
cord-001835-0s7ok4uw	408	23	,	,	,
cord-001835-0s7ok4uw	408	24	we	-PRON-	PRP
cord-001835-0s7ok4uw	408	25	have	have	VBP
cord-001835-0s7ok4uw	408	26	produced	produce	VBN
cord-001835-0s7ok4uw	408	27	and	and	CC
cord-001835-0s7ok4uw	408	28	are	be	VBP
cord-001835-0s7ok4uw	408	29	characterizing	characterize	VBG
cord-001835-0s7ok4uw	408	30	the	the	DT
cord-001835-0s7ok4uw	408	31	human	human	JJ
cord-001835-0s7ok4uw	408	32	MICAL1	MICAL1	NNP
cord-001835-0s7ok4uw	408	33	(	(	-LRB-
cord-001835-0s7ok4uw	408	34	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	408	35	-	-	HYPH
cord-001835-0s7ok4uw	408	36	FL	FL	NNP
cord-001835-0s7ok4uw	408	37	)	)	-RRB-
cord-001835-0s7ok4uw	408	38	and	and	CC
cord-001835-0s7ok4uw	408	39	forms	form	NNS
cord-001835-0s7ok4uw	408	40	containing	contain	VBG
cord-001835-0s7ok4uw	408	41	the	the	DT
cord-001835-0s7ok4uw	408	42	MO	MO	NNP
cord-001835-0s7ok4uw	408	43	[	[	-LRB-
cord-001835-0s7ok4uw	408	44	2	2	CD
cord-001835-0s7ok4uw	408	45	]	]	-RRB-
cord-001835-0s7ok4uw	408	46	,	,	,
cord-001835-0s7ok4uw	408	47	MO	MO	NNP
cord-001835-0s7ok4uw	408	48	-	-	HYPH
cord-001835-0s7ok4uw	408	49	CH	CH	NNP
cord-001835-0s7ok4uw	408	50	and	and	CC
cord-001835-0s7ok4uw	408	51	MO	MO	NNP
cord-001835-0s7ok4uw	408	52	-	-	HYPH
cord-001835-0s7ok4uw	408	53	CH	CH	NNP
cord-001835-0s7ok4uw	408	54	-	-	HYPH
cord-001835-0s7ok4uw	408	55	LIM	LIM	NNP
cord-001835-0s7ok4uw	408	56	domains	domain	NNS
cord-001835-0s7ok4uw	408	57	.	.	.
cord-001835-0s7ok4uw	409	1	All	all	DT
cord-001835-0s7ok4uw	409	2	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	409	3	forms	form	NNS
cord-001835-0s7ok4uw	409	4	contain	contain	VBP
cord-001835-0s7ok4uw	409	5	stoichiometric	stoichiometric	JJ
cord-001835-0s7ok4uw	409	6	amounts	amount	NNS
cord-001835-0s7ok4uw	409	7	of	of	IN
cord-001835-0s7ok4uw	409	8	FAD	fad	NN
cord-001835-0s7ok4uw	409	9	in	in	IN
cord-001835-0s7ok4uw	409	10	the	the	DT
cord-001835-0s7ok4uw	409	11	MO	MO	NNP
cord-001835-0s7ok4uw	409	12	domain	domain	NN
cord-001835-0s7ok4uw	409	13	and	and	CC
cord-001835-0s7ok4uw	409	14	2	2	CD
cord-001835-0s7ok4uw	409	15	Zn11	zn11	NN
cord-001835-0s7ok4uw	409	16	ions	ion	NNS
cord-001835-0s7ok4uw	409	17	in	in	IN
cord-001835-0s7ok4uw	409	18	the	the	DT
cord-001835-0s7ok4uw	409	19	LIM	LIM	NNP
cord-001835-0s7ok4uw	409	20	domain	domain	NN
cord-001835-0s7ok4uw	409	21	.	.	.
cord-001835-0s7ok4uw	410	1	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	410	2	-	-	HYPH
cord-001835-0s7ok4uw	410	3	MO	MO	NNP
cord-001835-0s7ok4uw	410	4	catalyzes	catalyze	VBZ
cord-001835-0s7ok4uw	410	5	a	a	DT
cord-001835-0s7ok4uw	410	6	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	410	7	oxidase	oxidase	NN
cord-001835-0s7ok4uw	410	8	(	(	-LRB-
cord-001835-0s7ok4uw	410	9	H2O2-producing	h2o2-produce	VBG
cord-001835-0s7ok4uw	410	10	)	)	-RRB-
cord-001835-0s7ok4uw	410	11	activity	activity	NN
cord-001835-0s7ok4uw	410	12	.	.	.
cord-001835-0s7ok4uw	411	1	The	the	DT
cord-001835-0s7ok4uw	411	2	CH	CH	NNP
cord-001835-0s7ok4uw	411	3	,	,	,
cord-001835-0s7ok4uw	411	4	LIM	LIM	NNP
cord-001835-0s7ok4uw	411	5	and	and	CC
cord-001835-0s7ok4uw	411	6	C	C	NNP
cord-001835-0s7ok4uw	411	7	-	-	HYPH
cord-001835-0s7ok4uw	411	8	terminal	terminal	NN
cord-001835-0s7ok4uw	411	9	domains	domain	NNS
cord-001835-0s7ok4uw	411	10	lower	lower	VBP
cord-001835-0s7ok4uw	411	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	411	12	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	411	13	efficiency	efficiency	NN
cord-001835-0s7ok4uw	411	14	(	(	-LRB-
cord-001835-0s7ok4uw	411	15	kcat	kcat	NNP
cord-001835-0s7ok4uw	411	16	/	/	SYM
cord-001835-0s7ok4uw	411	17	Km	Km	NNP
cord-001835-0s7ok4uw	411	18	,	,	,
cord-001835-0s7ok4uw	411	19	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	411	20	)	)	-RRB-
cord-001835-0s7ok4uw	411	21	mainly	mainly	RB
cord-001835-0s7ok4uw	411	22	due	due	IN
cord-001835-0s7ok4uw	411	23	to	to	IN
cord-001835-0s7ok4uw	411	24	an	an	DT
cord-001835-0s7ok4uw	411	25	increase	increase	NN
cord-001835-0s7ok4uw	411	26	of	of	IN
cord-001835-0s7ok4uw	411	27	Km	Km	NNP
cord-001835-0s7ok4uw	411	28	for	for	IN
cord-001835-0s7ok4uw	411	29	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	411	30	.	.	.
cord-001835-0s7ok4uw	412	1	The	the	DT
cord-001835-0s7ok4uw	412	2	kcat	kcat	NNP
cord-001835-0s7ok4uw	412	3	is	be	VBZ
cord-001835-0s7ok4uw	412	4	similar	similar	JJ
cord-001835-0s7ok4uw	412	5	for	for	IN
cord-001835-0s7ok4uw	412	6	all	all	DT
cord-001835-0s7ok4uw	412	7	forms	form	NNS
cord-001835-0s7ok4uw	412	8	excepted	except	VBN
cord-001835-0s7ok4uw	412	9	for	for	IN
cord-001835-0s7ok4uw	412	10	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	412	11	-	-	HYPH
cord-001835-0s7ok4uw	412	12	FL	FL	NNP
cord-001835-0s7ok4uw	412	13	where	where	WRB
cord-001835-0s7ok4uw	412	14	a	a	DT
cord-001835-0s7ok4uw	412	15	7-fold	7-fold	CD
cord-001835-0s7ok4uw	412	16	drop	drop	NN
cord-001835-0s7ok4uw	412	17	is	be	VBZ
cord-001835-0s7ok4uw	412	18	observed	observe	VBN
cord-001835-0s7ok4uw	412	19	,	,	,
cord-001835-0s7ok4uw	412	20	in	in	IN
cord-001835-0s7ok4uw	412	21	agreement	agreement	NN
cord-001835-0s7ok4uw	412	22	with	with	IN
cord-001835-0s7ok4uw	412	23	the	the	DT
cord-001835-0s7ok4uw	412	24	proposed	propose	VBN
cord-001835-0s7ok4uw	412	25	autoinhibitory	autoinhibitory	JJ
cord-001835-0s7ok4uw	412	26	function	function	NN
cord-001835-0s7ok4uw	412	27	of	of	IN
cord-001835-0s7ok4uw	412	28	the	the	DT
cord-001835-0s7ok4uw	412	29	C	C	NNP
cord-001835-0s7ok4uw	412	30	-	-	HYPH
cord-001835-0s7ok4uw	412	31	terminal	terminal	NN
cord-001835-0s7ok4uw	412	32	domain	domain	NN
cord-001835-0s7ok4uw	412	33	[	[	-LRB-
cord-001835-0s7ok4uw	412	34	3	3	CD
cord-001835-0s7ok4uw	412	35	]	]	-RRB-
cord-001835-0s7ok4uw	412	36	.	.	.
cord-001835-0s7ok4uw	413	1	The	the	DT
cord-001835-0s7ok4uw	413	2	pH	pH	NNP
cord-001835-0s7ok4uw	413	3	dependence	dependence	NN
cord-001835-0s7ok4uw	413	4	of	of	IN
cord-001835-0s7ok4uw	413	5	the	the	DT
cord-001835-0s7ok4uw	413	6	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	413	7	parameters	parameter	NNS
cord-001835-0s7ok4uw	413	8	of	of	IN
cord-001835-0s7ok4uw	413	9	MO	MO	NNP
cord-001835-0s7ok4uw	413	10	,	,	,
cord-001835-0s7ok4uw	413	11	MOCH	MOCH	NNP
cord-001835-0s7ok4uw	413	12	and	and	CC
cord-001835-0s7ok4uw	413	13	MOCHLIM	MOCHLIM	NNP
cord-001835-0s7ok4uw	413	14	is	be	VBZ
cord-001835-0s7ok4uw	413	15	complex	complex	JJ
cord-001835-0s7ok4uw	413	16	suggesting	suggest	VBG
cord-001835-0s7ok4uw	413	17	that	that	IN
cord-001835-0s7ok4uw	413	18	it	-PRON-	PRP
cord-001835-0s7ok4uw	413	19	does	do	VBZ
cord-001835-0s7ok4uw	413	20	not	not	RB
cord-001835-0s7ok4uw	413	21	reflect	reflect	VB
cord-001835-0s7ok4uw	413	22	the	the	DT
cord-001835-0s7ok4uw	413	23	ionization	ionization	NN
cord-001835-0s7ok4uw	413	24	state	state	NN
cord-001835-0s7ok4uw	413	25	of	of	IN
cord-001835-0s7ok4uw	413	26	individual	individual	JJ
cord-001835-0s7ok4uw	413	27	groups	group	NNS
cord-001835-0s7ok4uw	413	28	,	,	,
cord-001835-0s7ok4uw	413	29	but	but	CC
cord-001835-0s7ok4uw	413	30	rather	rather	RB
cord-001835-0s7ok4uw	413	31	the	the	DT
cord-001835-0s7ok4uw	413	32	overall	overall	JJ
cord-001835-0s7ok4uw	413	33	protein	protein	NN
cord-001835-0s7ok4uw	413	34	charge	charge	NN
cord-001835-0s7ok4uw	413	35	.	.	.
cord-001835-0s7ok4uw	414	1	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	414	2	-	-	HYPH
cord-001835-0s7ok4uw	414	3	MO	MO	NNP
cord-001835-0s7ok4uw	414	4	,	,	,
cord-001835-0s7ok4uw	414	5	-MOCH	-MOCH	NNP
cord-001835-0s7ok4uw	415	1	and	and	CC
cord-001835-0s7ok4uw	415	2	-MOCHLIM	-mochlim	RB
cord-001835-0s7ok4uw	415	3	catalyze	catalyze	VB
cord-001835-0s7ok4uw	415	4	a	a	DT
cord-001835-0s7ok4uw	415	5	NADPH	nadph	NN
cord-001835-0s7ok4uw	415	6	-	-	HYPH
cord-001835-0s7ok4uw	415	7	dependent	dependent	JJ
cord-001835-0s7ok4uw	415	8	F	F	NNP
cord-001835-0s7ok4uw	415	9	-	-	HYPH
cord-001835-0s7ok4uw	415	10	actin	actin	JJ
cord-001835-0s7ok4uw	415	11	depolymerization	depolymerization	NN
cord-001835-0s7ok4uw	415	12	with	with	IN
cord-001835-0s7ok4uw	415	13	a	a	DT
cord-001835-0s7ok4uw	415	14	similar	similar	JJ
cord-001835-0s7ok4uw	415	15	apparent	apparent	JJ
cord-001835-0s7ok4uw	415	16	Km	km	NN
cord-001835-0s7ok4uw	415	17	for	for	IN
cord-001835-0s7ok4uw	415	18	actin	actin	NN
cord-001835-0s7ok4uw	415	19	.	.	.
cord-001835-0s7ok4uw	416	1	F	F	NNP
cord-001835-0s7ok4uw	416	2	-	-	HYPH
cord-001835-0s7ok4uw	416	3	actin	actin	NNP
cord-001835-0s7ok4uw	416	4	(	(	-LRB-
cord-001835-0s7ok4uw	416	5	but	but	CC
cord-001835-0s7ok4uw	416	6	not	not	RB
cord-001835-0s7ok4uw	416	7	G	g	NN
cord-001835-0s7ok4uw	416	8	-	-	HYPH
cord-001835-0s7ok4uw	416	9	actin	actin	NN
cord-001835-0s7ok4uw	416	10	)	)	-RRB-
cord-001835-0s7ok4uw	416	11	stimulates	stimulate	VBZ
cord-001835-0s7ok4uw	416	12	the	the	DT
cord-001835-0s7ok4uw	416	13	rate	rate	NN
cord-001835-0s7ok4uw	416	14	of	of	IN
cord-001835-0s7ok4uw	416	15	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	416	16	oxidation	oxidation	NN
cord-001835-0s7ok4uw	416	17	by	by	IN
cord-001835-0s7ok4uw	416	18	increasing	increase	VBG
cord-001835-0s7ok4uw	416	19	kcat	kcat	NNP
cord-001835-0s7ok4uw	416	20	and	and	CC
cord-001835-0s7ok4uw	416	21	lowering	lower	VBG
cord-001835-0s7ok4uw	416	22	KNADPH	KNADPH	NNP
cord-001835-0s7ok4uw	416	23	.	.	.
cord-001835-0s7ok4uw	417	1	The	the	DT
cord-001835-0s7ok4uw	417	2	extent	extent	NN
cord-001835-0s7ok4uw	417	3	of	of	IN
cord-001835-0s7ok4uw	417	4	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	417	5	oxidation	oxidation	NN
cord-001835-0s7ok4uw	417	6	exceeds	exceed	VBZ
cord-001835-0s7ok4uw	417	7	total	total	JJ
cord-001835-0s7ok4uw	417	8	F	F	NNP
cord-001835-0s7ok4uw	417	9	-	-	HYPH
cord-001835-0s7ok4uw	417	10	actin	actin	NNP
cord-001835-0s7ok4uw	417	11	which	which	WDT
cord-001835-0s7ok4uw	417	12	is	be	VBZ
cord-001835-0s7ok4uw	417	13	in	in	IN
cord-001835-0s7ok4uw	417	14	contrast	contrast	NN
cord-001835-0s7ok4uw	417	15	with	with	IN
cord-001835-0s7ok4uw	417	16	the	the	DT
cord-001835-0s7ok4uw	417	17	proposal	proposal	NN
cord-001835-0s7ok4uw	417	18	of	of	IN
cord-001835-0s7ok4uw	417	19	specific	specific	JJ
cord-001835-0s7ok4uw	417	20	modification	modification	NN
cord-001835-0s7ok4uw	417	21	of	of	IN
cord-001835-0s7ok4uw	417	22	actin	actin	NN
cord-001835-0s7ok4uw	417	23	Met44	Met44	NNP
cord-001835-0s7ok4uw	417	24	or	or	CC
cord-001835-0s7ok4uw	417	25	Met46	Met46	NNP
cord-001835-0s7ok4uw	417	26	reported	report	VBD
cord-001835-0s7ok4uw	417	27	for	for	IN
cord-001835-0s7ok4uw	417	28	Drosophila	Drosophila	NNP
cord-001835-0s7ok4uw	417	29	and	and	CC
cord-001835-0s7ok4uw	417	30	mouse	mouse	NN
cord-001835-0s7ok4uw	417	31	MOCH	MOCH	NNP
cord-001835-0s7ok4uw	417	32	[	[	-LRB-
cord-001835-0s7ok4uw	417	33	4	4	CD
cord-001835-0s7ok4uw	417	34	]	]	-RRB-
cord-001835-0s7ok4uw	417	35	[	[	-LRB-
cord-001835-0s7ok4uw	417	36	5	5	CD
cord-001835-0s7ok4uw	417	37	]	]	-RRB-
cord-001835-0s7ok4uw	417	38	,	,	,
cord-001835-0s7ok4uw	417	39	but	but	CC
cord-001835-0s7ok4uw	417	40	it	-PRON-	PRP
cord-001835-0s7ok4uw	417	41	suggests	suggest	VBZ
cord-001835-0s7ok4uw	417	42	that	that	IN
cord-001835-0s7ok4uw	417	43	F	f	NN
cord-001835-0s7ok4uw	417	44	-	-	HYPH
cord-001835-0s7ok4uw	417	45	actin	actin	NNP
cord-001835-0s7ok4uw	417	46	stimulates	stimulate	VBZ
cord-001835-0s7ok4uw	417	47	the	the	DT
cord-001835-0s7ok4uw	417	48	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	417	49	oxidase	oxidase	NN
cord-001835-0s7ok4uw	417	50	activity	activity	NN
cord-001835-0s7ok4uw	417	51	or	or	CC
cord-001835-0s7ok4uw	417	52	a	a	DT
cord-001835-0s7ok4uw	417	53	case	case	NN
cord-001835-0s7ok4uw	417	54	of	of	IN
cord-001835-0s7ok4uw	417	55	substrate	substrate	NN
cord-001835-0s7ok4uw	417	56	recycling	recycling	NN
cord-001835-0s7ok4uw	417	57	.	.	.
cord-001835-0s7ok4uw	418	1	Accordingly	accordingly	RB
cord-001835-0s7ok4uw	418	2	,	,	,
cord-001835-0s7ok4uw	418	3	with	with	IN
cord-001835-0s7ok4uw	418	4	hMICAL	hMICAL	NNP
cord-001835-0s7ok4uw	418	5	MO	MO	NNP
cord-001835-0s7ok4uw	418	6	and	and	CC
cord-001835-0s7ok4uw	418	7	MOCH	MOCH	NNP
cord-001835-0s7ok4uw	418	8	several	several	JJ
cord-001835-0s7ok4uw	418	9	actin	actin	NN
cord-001835-0s7ok4uw	418	10	residues	residue	NNS
cord-001835-0s7ok4uw	418	11	are	be	VBP
cord-001835-0s7ok4uw	418	12	oxidized	oxidize	VBN
cord-001835-0s7ok4uw	418	13	beside	beside	IN
cord-001835-0s7ok4uw	418	14	Met44	Met44	NNP
cord-001835-0s7ok4uw	418	15	and	and	CC
cord-001835-0s7ok4uw	418	16	Met46	Met46	NNP
cord-001835-0s7ok4uw	418	17	.	.	.
cord-001835-0s7ok4uw	419	1	Thus	thus	RB
cord-001835-0s7ok4uw	419	2	,	,	,
cord-001835-0s7ok4uw	419	3	the	the	DT
cord-001835-0s7ok4uw	419	4	CH	CH	NNP
cord-001835-0s7ok4uw	419	5	and	and	CC
cord-001835-0s7ok4uw	419	6	LIM	LIM	NNP
cord-001835-0s7ok4uw	419	7	domains	domain	NNS
cord-001835-0s7ok4uw	419	8	do	do	VBP
cord-001835-0s7ok4uw	419	9	not	not	RB
cord-001835-0s7ok4uw	419	10	seem	seem	VB
cord-001835-0s7ok4uw	419	11	to	to	TO
cord-001835-0s7ok4uw	419	12	be	be	VB
cord-001835-0s7ok4uw	419	13	important	important	JJ
cord-001835-0s7ok4uw	419	14	for	for	IN
cord-001835-0s7ok4uw	419	15	the	the	DT
cord-001835-0s7ok4uw	419	16	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	419	17	-	-	HYPH
cord-001835-0s7ok4uw	419	18	actin	actin	VBG
cord-001835-0s7ok4uw	419	19	interaction	interaction	NN
cord-001835-0s7ok4uw	419	20	and	and	CC
cord-001835-0s7ok4uw	419	21	actin	actin	NN
cord-001835-0s7ok4uw	419	22	modification	modification	NN
cord-001835-0s7ok4uw	419	23	may	may	MD
cord-001835-0s7ok4uw	419	24	be	be	VB
cord-001835-0s7ok4uw	419	25	mediated	mediate	VBN
cord-001835-0s7ok4uw	419	26	by	by	IN
cord-001835-0s7ok4uw	419	27	in	in	IN
cord-001835-0s7ok4uw	419	28	situ	situ	JJ
cord-001835-0s7ok4uw	419	29	H2O2	H2O2	NNP
cord-001835-0s7ok4uw	419	30	production	production	NN
cord-001835-0s7ok4uw	419	31	.	.	.
cord-001835-0s7ok4uw	420	1	In	in	IN
cord-001835-0s7ok4uw	420	2	HEK293	HEK293	NNP
cord-001835-0s7ok4uw	420	3	T	T	NNP
cord-001835-0s7ok4uw	420	4	and	and	CC
cord-001835-0s7ok4uw	420	5	COS-7	COS-7	NNP
cord-001835-0s7ok4uw	420	6	cells	cell	NNS
cord-001835-0s7ok4uw	420	7	mouse	mouse	NN
cord-001835-0s7ok4uw	420	8	collapsin	collapsin	NNP
cord-001835-0s7ok4uw	420	9	response	response	NN
cord-001835-0s7ok4uw	420	10	mediator	mediator	NN
cord-001835-0s7ok4uw	420	11	protein-1	protein-1	NNP
cord-001835-0s7ok4uw	420	12	(	(	-LRB-
cord-001835-0s7ok4uw	420	13	mCRMP1	mCRMP1	NNP
cord-001835-0s7ok4uw	420	14	)	)	-RRB-
cord-001835-0s7ok4uw	420	15	interacts	interact	VBZ
cord-001835-0s7ok4uw	420	16	with	with	IN
cord-001835-0s7ok4uw	420	17	MICAL1	MICAL1	NNS
cord-001835-0s7ok4uw	420	18	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	420	19	H2O2	H2O2	NNP
cord-001835-0s7ok4uw	420	20	production	production	NN
cord-001835-0s7ok4uw	420	21	[	[	-LRB-
cord-001835-0s7ok4uw	420	22	3	3	CD
cord-001835-0s7ok4uw	420	23	]	]	-RRB-
cord-001835-0s7ok4uw	420	24	,	,	,
cord-001835-0s7ok4uw	420	25	suggesting	suggest	VBG
cord-001835-0s7ok4uw	420	26	that	that	IN
cord-001835-0s7ok4uw	420	27	CRMP1	crmp1	DT
cord-001835-0s7ok4uw	420	28	could	could	MD
cord-001835-0s7ok4uw	420	29	be	be	VB
cord-001835-0s7ok4uw	420	30	a	a	DT
cord-001835-0s7ok4uw	420	31	hydroxylatable	hydroxylatable	JJ
cord-001835-0s7ok4uw	420	32	substrate	substrate	NN
cord-001835-0s7ok4uw	420	33	of	of	IN
cord-001835-0s7ok4uw	420	34	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	420	35	-	-	HYPH
cord-001835-0s7ok4uw	420	36	MO	MO	NNP
cord-001835-0s7ok4uw	420	37	.	.	.
cord-001835-0s7ok4uw	421	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	421	2	have	have	VBP
cord-001835-0s7ok4uw	421	3	produced	produce	VBN
cord-001835-0s7ok4uw	421	4	the	the	DT
cord-001835-0s7ok4uw	421	5	same	same	JJ
cord-001835-0s7ok4uw	421	6	mCRMP1	mCRMP1	NNP
cord-001835-0s7ok4uw	421	7	form	form	NN
cord-001835-0s7ok4uw	421	8	(	(	-LRB-
cord-001835-0s7ok4uw	421	9	8	8	CD
cord-001835-0s7ok4uw	421	10	-	-	SYM
cord-001835-0s7ok4uw	421	11	525	525	CD
cord-001835-0s7ok4uw	421	12	aa	aa	NN
cord-001835-0s7ok4uw	421	13	)	)	-RRB-
cord-001835-0s7ok4uw	421	14	and	and	CC
cord-001835-0s7ok4uw	421	15	we	-PRON-	PRP
cord-001835-0s7ok4uw	421	16	have	have	VBP
cord-001835-0s7ok4uw	421	17	shown	show	VBN
cord-001835-0s7ok4uw	421	18	that	that	IN
cord-001835-0s7ok4uw	421	19	under	under	IN
cord-001835-0s7ok4uw	421	20	conditions	condition	NNS
cord-001835-0s7ok4uw	421	21	that	that	WDT
cord-001835-0s7ok4uw	421	22	limit	limit	VBP
cord-001835-0s7ok4uw	421	23	non	non	JJ
cord-001835-0s7ok4uw	421	24	specific	specific	JJ
cord-001835-0s7ok4uw	421	25	interactions	interaction	NNS
cord-001835-0s7ok4uw	421	26	a	a	DT
cord-001835-0s7ok4uw	421	27	mild	mild	JJ
cord-001835-0s7ok4uw	421	28	stimulation	stimulation	NN
cord-001835-0s7ok4uw	421	29	(	(	-LRB-
cord-001835-0s7ok4uw	421	30	up	up	IN
cord-001835-0s7ok4uw	421	31	to	to	TO
cord-001835-0s7ok4uw	421	32	20	20	CD
cord-001835-0s7ok4uw	421	33	%	%	NN
cord-001835-0s7ok4uw	421	34	)	)	-RRB-
cord-001835-0s7ok4uw	421	35	of	of	IN
cord-001835-0s7ok4uw	421	36	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	421	37	oxidation	oxidation	NN
cord-001835-0s7ok4uw	421	38	is	be	VBZ
cord-001835-0s7ok4uw	421	39	observed	observe	VBN
cord-001835-0s7ok4uw	421	40	.	.	.
cord-001835-0s7ok4uw	422	1	F	F	NNP
cord-001835-0s7ok4uw	422	2	-	-	HYPH
cord-001835-0s7ok4uw	422	3	actin	actin	NNP
cord-001835-0s7ok4uw	422	4	reversed	reverse	VBD
cord-001835-0s7ok4uw	422	5	the	the	DT
cord-001835-0s7ok4uw	422	6	effect	effect	NN
cord-001835-0s7ok4uw	422	7	of	of	IN
cord-001835-0s7ok4uw	422	8	mCRMP1	mCRMP1	NNP
cord-001835-0s7ok4uw	422	9	suggesting	suggest	VBG
cord-001835-0s7ok4uw	422	10	their	-PRON-	PRP$
cord-001835-0s7ok4uw	422	11	competition	competition	NN
cord-001835-0s7ok4uw	422	12	for	for	IN
cord-001835-0s7ok4uw	422	13	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	422	14	.	.	.
cord-001835-0s7ok4uw	423	1	These	these	DT
cord-001835-0s7ok4uw	423	2	results	result	NNS
cord-001835-0s7ok4uw	423	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	423	4	that	that	IN
cord-001835-0s7ok4uw	423	5	CRMP1	crmp1	RB
cord-001835-0s7ok4uw	423	6	,	,	,
cord-001835-0s7ok4uw	423	7	a	a	DT
cord-001835-0s7ok4uw	423	8	major	major	JJ
cord-001835-0s7ok4uw	423	9	microtubules	microtubule	NNS
cord-001835-0s7ok4uw	423	10	regulator	regulator	NN
cord-001835-0s7ok4uw	423	11	,	,	,
cord-001835-0s7ok4uw	423	12	is	be	VBZ
cord-001835-0s7ok4uw	423	13	not	not	RB
cord-001835-0s7ok4uw	423	14	the	the	DT
cord-001835-0s7ok4uw	423	15	substrate	substrate	NN
cord-001835-0s7ok4uw	423	16	of	of	IN
cord-001835-0s7ok4uw	423	17	the	the	DT
cord-001835-0s7ok4uw	423	18	MO	MO	NNP
cord-001835-0s7ok4uw	423	19	domain	domain	NN
cord-001835-0s7ok4uw	423	20	,	,	,
cord-001835-0s7ok4uw	423	21	but	but	CC
cord-001835-0s7ok4uw	423	22	actin	actin	NN
cord-001835-0s7ok4uw	423	23	and	and	CC
cord-001835-0s7ok4uw	423	24	microtubules	microtubule	VBZ
cord-001835-0s7ok4uw	423	25	cytoskeleton	cytoskeleton	NN
cord-001835-0s7ok4uw	423	26	components	component	NNS
cord-001835-0s7ok4uw	423	27	may	may	MD
cord-001835-0s7ok4uw	423	28	be	be	VB
cord-001835-0s7ok4uw	423	29	linked	link	VBN
cord-001835-0s7ok4uw	423	30	through	through	IN
cord-001835-0s7ok4uw	423	31	the	the	DT
cord-001835-0s7ok4uw	423	32	formation	formation	NN
cord-001835-0s7ok4uw	423	33	of	of	IN
cord-001835-0s7ok4uw	423	34	CRMP	CRMP	NNP
cord-001835-0s7ok4uw	423	35	-	-	HYPH
cord-001835-0s7ok4uw	423	36	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	423	37	complex	complex	NN
cord-001835-0s7ok4uw	423	38	in	in	IN
cord-001835-0s7ok4uw	423	39	response	response	NN
cord-001835-0s7ok4uw	423	40	to	to	IN
cord-001835-0s7ok4uw	423	41	semaphorin	semaphorin	JJ
cord-001835-0s7ok4uw	423	42	-	-	HYPH
cord-001835-0s7ok4uw	423	43	plexin	plexin	NN
cord-001835-0s7ok4uw	423	44	signaling	signaling	NN
cord-001835-0s7ok4uw	423	45	.	.	.
cord-001835-0s7ok4uw	424	1	Experiments	experiment	NNS
cord-001835-0s7ok4uw	424	2	are	be	VBP
cord-001835-0s7ok4uw	424	3	in	in	IN
cord-001835-0s7ok4uw	424	4	progress	progress	NN
cord-001835-0s7ok4uw	424	5	to	to	TO
cord-001835-0s7ok4uw	424	6	complete	complete	VB
cord-001835-0s7ok4uw	424	7	the	the	DT
cord-001835-0s7ok4uw	424	8	characterization	characterization	NN
cord-001835-0s7ok4uw	424	9	of	of	IN
cord-001835-0s7ok4uw	424	10	MOCHLIM	MOCHLIM	NNP
cord-001835-0s7ok4uw	424	11	and	and	CC
cord-001835-0s7ok4uw	424	12	full	full	JJ
cord-001835-0s7ok4uw	424	13	length	length	NN
cord-001835-0s7ok4uw	424	14	MICAL	MICAL	NNP
cord-001835-0s7ok4uw	424	15	forms	form	NNS
cord-001835-0s7ok4uw	424	16	.	.	.
cord-001835-0s7ok4uw	425	1	Green	green	JJ
cord-001835-0s7ok4uw	425	2	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	425	3	protein	protein	NN
cord-001835-0s7ok4uw	425	4	(	(	-LRB-
cord-001835-0s7ok4uw	425	5	GFP	GFP	NNP
cord-001835-0s7ok4uw	425	6	)	)	-RRB-
cord-001835-0s7ok4uw	425	7	,	,	,
cord-001835-0s7ok4uw	425	8	owing	owe	VBG
cord-001835-0s7ok4uw	425	9	to	to	IN
cord-001835-0s7ok4uw	425	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	425	11	genetically	genetically	RB
cord-001835-0s7ok4uw	425	12	encoded	encode	VBN
cord-001835-0s7ok4uw	425	13	strong	strong	JJ
cord-001835-0s7ok4uw	425	14	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	425	15	,	,	,
cord-001835-0s7ok4uw	425	16	has	have	VBZ
cord-001835-0s7ok4uw	425	17	become	become	VBN
cord-001835-0s7ok4uw	425	18	one	one	CD
cord-001835-0s7ok4uw	425	19	of	of	IN
cord-001835-0s7ok4uw	425	20	the	the	DT
cord-001835-0s7ok4uw	425	21	most	most	RBS
cord-001835-0s7ok4uw	425	22	important	important	JJ
cord-001835-0s7ok4uw	425	23	tools	tool	NNS
cord-001835-0s7ok4uw	425	24	in	in	IN
cord-001835-0s7ok4uw	425	25	modern	modern	JJ
cord-001835-0s7ok4uw	425	26	biology	biology	NN
cord-001835-0s7ok4uw	425	27	[	[	-LRB-
cord-001835-0s7ok4uw	425	28	1	1	CD
cord-001835-0s7ok4uw	425	29	]	]	-RRB-
cord-001835-0s7ok4uw	425	30	.	.	.
cord-001835-0s7ok4uw	426	1	Enhanced	enhanced	JJ
cord-001835-0s7ok4uw	426	2	GFP	GFP	NNP
cord-001835-0s7ok4uw	426	3	(	(	-LRB-
cord-001835-0s7ok4uw	426	4	EGFP	EGFP	NNP
cord-001835-0s7ok4uw	426	5	,	,	,
cord-001835-0s7ok4uw	426	6	F64L	F64L	NNP
cord-001835-0s7ok4uw	426	7	/	/	SYM
cord-001835-0s7ok4uw	426	8	S65T	s65t	NN
cord-001835-0s7ok4uw	426	9	-	-	HYPH
cord-001835-0s7ok4uw	426	10	GFP	GFP	NNP
cord-001835-0s7ok4uw	426	11	)	)	-RRB-
cord-001835-0s7ok4uw	426	12	,	,	,
cord-001835-0s7ok4uw	426	13	frequently	frequently	RB
cord-001835-0s7ok4uw	426	14	used	use	VBN
cord-001835-0s7ok4uw	426	15	variants	variant	NNS
cord-001835-0s7ok4uw	426	16	of	of	IN
cord-001835-0s7ok4uw	426	17	this	this	DT
cord-001835-0s7ok4uw	426	18	protein	protein	NN
cord-001835-0s7ok4uw	426	19	,	,	,
cord-001835-0s7ok4uw	426	20	is	be	VBZ
cord-001835-0s7ok4uw	426	21	thermodynamically	thermodynamically	RB
cord-001835-0s7ok4uw	426	22	more	more	RBR
cord-001835-0s7ok4uw	426	23	stable	stable	JJ
cord-001835-0s7ok4uw	426	24	and	and	CC
cord-001835-0s7ok4uw	426	25	35-times	35-times	CD
cord-001835-0s7ok4uw	426	26	brighter	bright	JJR
cord-001835-0s7ok4uw	426	27	than	than	IN
cord-001835-0s7ok4uw	426	28	GFP	GFP	NNP
cord-001835-0s7ok4uw	426	29	[	[	-LRB-
cord-001835-0s7ok4uw	426	30	2	2	CD
cord-001835-0s7ok4uw	426	31	]	]	-RRB-
cord-001835-0s7ok4uw	426	32	.	.	.
cord-001835-0s7ok4uw	427	1	Due	due	IN
cord-001835-0s7ok4uw	427	2	to	to	IN
cord-001835-0s7ok4uw	427	3	the	the	DT
cord-001835-0s7ok4uw	427	4	improved	improved	JJ
cord-001835-0s7ok4uw	427	5	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	427	6	properties	property	NNS
cord-001835-0s7ok4uw	427	7	,	,	,
cord-001835-0s7ok4uw	427	8	EGFP	EGFP	NNP
cord-001835-0s7ok4uw	427	9	is	be	VBZ
cord-001835-0s7ok4uw	427	10	commonly	commonly	RB
cord-001835-0s7ok4uw	427	11	used	use	VBN
cord-001835-0s7ok4uw	427	12	as	as	IN
cord-001835-0s7ok4uw	427	13	a	a	DT
cord-001835-0s7ok4uw	427	14	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	427	15	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	427	16	marker	marker	NN
cord-001835-0s7ok4uw	427	17	in	in	IN
cord-001835-0s7ok4uw	427	18	bio	bio	NNP
cord-001835-0s7ok4uw	427	19	-	-	NN
cord-001835-0s7ok4uw	427	20	imaging	imaging	NN
cord-001835-0s7ok4uw	427	21	in	in	IN
cord-001835-0s7ok4uw	427	22	vitro	vitro	FW
cord-001835-0s7ok4uw	427	23	and	and	CC
cord-001835-0s7ok4uw	427	24	in	in	IN
cord-001835-0s7ok4uw	427	25	vivo	vivo	NNP
cord-001835-0s7ok4uw	427	26	.	.	.
cord-001835-0s7ok4uw	428	1	Despite	despite	IN
cord-001835-0s7ok4uw	428	2	sustained	sustained	JJ
cord-001835-0s7ok4uw	428	3	interest	interest	NN
cord-001835-0s7ok4uw	428	4	of	of	IN
cord-001835-0s7ok4uw	428	5	the	the	DT
cord-001835-0s7ok4uw	428	6	scientific	scientific	JJ
cord-001835-0s7ok4uw	428	7	community	community	NN
cord-001835-0s7ok4uw	428	8	and	and	CC
cord-001835-0s7ok4uw	428	9	numerous	numerous	JJ
cord-001835-0s7ok4uw	428	10	practical	practical	JJ
cord-001835-0s7ok4uw	428	11	applications	application	NNS
cord-001835-0s7ok4uw	428	12	,	,	,
cord-001835-0s7ok4uw	428	13	the	the	DT
cord-001835-0s7ok4uw	428	14	actual	actual	JJ
cord-001835-0s7ok4uw	428	15	biological	biological	JJ
cord-001835-0s7ok4uw	428	16	role	role	NN
cord-001835-0s7ok4uw	428	17	of	of	IN
cord-001835-0s7ok4uw	428	18	GFP	GFP	NNP
cord-001835-0s7ok4uw	428	19	remains	remain	VBZ
cord-001835-0s7ok4uw	428	20	elusive	elusive	JJ
cord-001835-0s7ok4uw	428	21	.	.	.
cord-001835-0s7ok4uw	429	1	Recent	recent	JJ
cord-001835-0s7ok4uw	429	2	reports	report	NNS
cord-001835-0s7ok4uw	429	3	put	put	VBD
cord-001835-0s7ok4uw	429	4	forward	forward	RP
cord-001835-0s7ok4uw	429	5	a	a	DT
cord-001835-0s7ok4uw	429	6	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	429	7	of	of	IN
cord-001835-0s7ok4uw	429	8	antioxidant	antioxidant	JJ
cord-001835-0s7ok4uw	429	9	and	and	CC
cord-001835-0s7ok4uw	429	10	photo	photo	NN
cord-001835-0s7ok4uw	429	11	-	-	HYPH
cord-001835-0s7ok4uw	429	12	protective	protective	JJ
cord-001835-0s7ok4uw	429	13	functions	function	NNS
cord-001835-0s7ok4uw	429	14	of	of	IN
cord-001835-0s7ok4uw	429	15	GFP	GFP	NNP
cord-001835-0s7ok4uw	429	16	[	[	-LRB-
cord-001835-0s7ok4uw	429	17	3	3	CD
cord-001835-0s7ok4uw	429	18	]	]	-RRB-
cord-001835-0s7ok4uw	429	19	.	.	.
cord-001835-0s7ok4uw	430	1	In	in	IN
cord-001835-0s7ok4uw	430	2	this	this	DT
cord-001835-0s7ok4uw	430	3	study	study	NN
cord-001835-0s7ok4uw	430	4	,	,	,
cord-001835-0s7ok4uw	430	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	430	6	focused	focus	VBD
cord-001835-0s7ok4uw	430	7	on	on	IN
cord-001835-0s7ok4uw	430	8	the	the	DT
cord-001835-0s7ok4uw	430	9	photo	photo	NN
cord-001835-0s7ok4uw	430	10	-	-	HYPH
cord-001835-0s7ok4uw	430	11	protective	protective	JJ
cord-001835-0s7ok4uw	430	12	role	role	NN
cord-001835-0s7ok4uw	430	13	of	of	IN
cord-001835-0s7ok4uw	430	14	EGFP	EGFP	NNP
cord-001835-0s7ok4uw	430	15	against	against	IN
cord-001835-0s7ok4uw	430	16	reactive	reactive	JJ
cord-001835-0s7ok4uw	430	17	oxygen	oxygen	NN
cord-001835-0s7ok4uw	430	18	species	specie	NNS
cord-001835-0s7ok4uw	431	1	(	(	-LRB-
cord-001835-0s7ok4uw	431	2	ROS	ROS	NNP
cord-001835-0s7ok4uw	431	3	)	)	-RRB-
cord-001835-0s7ok4uw	431	4	photo	photo	NN
cord-001835-0s7ok4uw	431	5	-	-	HYPH
cord-001835-0s7ok4uw	431	6	generated	generate	VBN
cord-001835-0s7ok4uw	431	7	by	by	IN
cord-001835-0s7ok4uw	431	8	visible	visible	JJ
cord-001835-0s7ok4uw	431	9	light	light	NN
cord-001835-0s7ok4uw	431	10	in	in	IN
cord-001835-0s7ok4uw	431	11	water	water	NN
cord-001835-0s7ok4uw	431	12	suspensions	suspension	NNS
cord-001835-0s7ok4uw	431	13	of	of	IN
cord-001835-0s7ok4uw	431	14	nano	nano	NN
cord-001835-0s7ok4uw	431	15	-	-	HYPH
cord-001835-0s7ok4uw	431	16	particular	particular	JJ
cord-001835-0s7ok4uw	431	17	nitrogen	nitrogen	NN
cord-001835-0s7ok4uw	431	18	-	-	HYPH
cord-001835-0s7ok4uw	431	19	doped	dope	VBN
cord-001835-0s7ok4uw	431	20	titanium	titanium	NN
cord-001835-0s7ok4uw	431	21	oxide	oxide	NN
cord-001835-0s7ok4uw	431	22	(	(	-LRB-
cord-001835-0s7ok4uw	431	23	N	n	CD
cord-001835-0s7ok4uw	431	24	-	-	HYPH
cord-001835-0s7ok4uw	431	25	doped	dope	VBN
cord-001835-0s7ok4uw	431	26	nano	nano	NNP
cord-001835-0s7ok4uw	431	27	-	-	HYPH
cord-001835-0s7ok4uw	431	28	TiO2	TiO2	NNP
cord-001835-0s7ok4uw	431	29	)	)	-RRB-
cord-001835-0s7ok4uw	431	30	,	,	,
cord-001835-0s7ok4uw	431	31	that	that	DT
cord-001835-0s7ok4uw	431	32	is	be	VBZ
cord-001835-0s7ok4uw	431	33	in	in	IN
cord-001835-0s7ok4uw	431	34	the	the	DT
cord-001835-0s7ok4uw	431	35	system	system	NN
cord-001835-0s7ok4uw	431	36	:	:	:
cord-001835-0s7ok4uw	431	37	'	'	``
cord-001835-0s7ok4uw	431	38	N	n	CD
cord-001835-0s7ok4uw	431	39	-	-	HYPH
cord-001835-0s7ok4uw	431	40	doped	dope	VBN
cord-001835-0s7ok4uw	431	41	nano	nano	NN
cord-001835-0s7ok4uw	431	42	-	-	HYPH
cord-001835-0s7ok4uw	431	43	TiO2)/visible	tio2)/visible	JJ
cord-001835-0s7ok4uw	431	44	light	light	NN
cord-001835-0s7ok4uw	431	45	'	'	''
cord-001835-0s7ok4uw	431	46	.	.	.
cord-001835-0s7ok4uw	432	1	N	n	CD
cord-001835-0s7ok4uw	432	2	-	-	HYPH
cord-001835-0s7ok4uw	432	3	doped	dope	VBN
cord-001835-0s7ok4uw	432	4	nano	nano	NN
cord-001835-0s7ok4uw	432	5	-	-	HYPH
cord-001835-0s7ok4uw	432	6	TiO2	TiO2	NNP
cord-001835-0s7ok4uw	433	1	(	(	-LRB-
cord-001835-0s7ok4uw	433	2	Sumitomo	Sumitomo	NNP
cord-001835-0s7ok4uw	433	3	TP	TP	NNP
cord-001835-0s7ok4uw	433	4	-	-	HYPH
cord-001835-0s7ok4uw	433	5	S201	S201	NNP
cord-001835-0s7ok4uw	433	6	)	)	-RRB-
cord-001835-0s7ok4uw	433	7	was	be	VBD
cord-001835-0s7ok4uw	433	8	chosen	choose	VBN
cord-001835-0s7ok4uw	433	9	as	as	IN
cord-001835-0s7ok4uw	433	10	a	a	DT
cord-001835-0s7ok4uw	433	11	photo	photo	NN
cord-001835-0s7ok4uw	433	12	-	-	HYPH
cord-001835-0s7ok4uw	433	13	catalyst	catalyst	NN
cord-001835-0s7ok4uw	433	14	,	,	,
cord-001835-0s7ok4uw	433	15	since	since	IN
cord-001835-0s7ok4uw	433	16	it	-PRON-	PRP
cord-001835-0s7ok4uw	433	17	is	be	VBZ
cord-001835-0s7ok4uw	433	18	widely	widely	RB
cord-001835-0s7ok4uw	433	19	accepted	accept	VBN
cord-001835-0s7ok4uw	433	20	that	that	IN
cord-001835-0s7ok4uw	433	21	nitrogen	nitrogen	NN
cord-001835-0s7ok4uw	433	22	doping	doping	NN
cord-001835-0s7ok4uw	433	23	enhances	enhance	VBZ
cord-001835-0s7ok4uw	433	24	visible	visible	JJ
cord-001835-0s7ok4uw	433	25	light	light	JJ
cord-001835-0s7ok4uw	433	26	photoactivity	photoactivity	NN
cord-001835-0s7ok4uw	433	27	of	of	IN
cord-001835-0s7ok4uw	433	28	TiO2	TiO2	NNP
cord-001835-0s7ok4uw	433	29	.	.	.
cord-001835-0s7ok4uw	434	1	4-hydroxy-2,2,6,6-tetramethylpiperidine	4-hydroxy-2,2,6,6-tetramethylpiperidine	LS
cord-001835-0s7ok4uw	434	2	-	-	HYPH
cord-001835-0s7ok4uw	434	3	N	N	NNP
cord-001835-0s7ok4uw	434	4	-	-	HYPH
cord-001835-0s7ok4uw	434	5	oxyl	oxyl	NNP
cord-001835-0s7ok4uw	434	6	(	(	-LRB-
cord-001835-0s7ok4uw	434	7	TEMPOL	TEMPOL	NNP
cord-001835-0s7ok4uw	434	8	)	)	-RRB-
cord-001835-0s7ok4uw	434	9	,	,	,
cord-001835-0s7ok4uw	434	10	a	a	DT
cord-001835-0s7ok4uw	434	11	paramagnetic	paramagnetic	JJ
cord-001835-0s7ok4uw	434	12	water	water	NN
cord-001835-0s7ok4uw	434	13	-	-	HYPH
cord-001835-0s7ok4uw	434	14	soluble	soluble	JJ
cord-001835-0s7ok4uw	434	15	compound	compound	NN
cord-001835-0s7ok4uw	434	16	,	,	,
cord-001835-0s7ok4uw	434	17	belonging	belong	VBG
cord-001835-0s7ok4uw	434	18	to	to	IN
cord-001835-0s7ok4uw	434	19	the	the	DT
cord-001835-0s7ok4uw	434	20	nitroxide	nitroxide	NNP
cord-001835-0s7ok4uw	434	21	class	class	NN
cord-001835-0s7ok4uw	434	22	o	o	NN
cord-001835-0s7ok4uw	434	23	superoxide	superoxide	NN
cord-001835-0s7ok4uw	434	24	dismutase	dismutase	NN
cord-001835-0s7ok4uw	434	25	(	(	-LRB-
cord-001835-0s7ok4uw	434	26	SOD	SOD	NNP
cord-001835-0s7ok4uw	434	27	)	)	-RRB-
cord-001835-0s7ok4uw	434	28	mimetics	mimetic	NNS
cord-001835-0s7ok4uw	434	29	,	,	,
cord-001835-0s7ok4uw	434	30	was	be	VBD
cord-001835-0s7ok4uw	434	31	used	use	VBN
cord-001835-0s7ok4uw	434	32	as	as	IN
cord-001835-0s7ok4uw	434	33	a	a	DT
cord-001835-0s7ok4uw	434	34	target	target	NN
cord-001835-0s7ok4uw	434	35	for	for	IN
cord-001835-0s7ok4uw	434	36	photo	photo	NN
cord-001835-0s7ok4uw	434	37	-	-	HYPH
cord-001835-0s7ok4uw	434	38	generated	generate	VBN
cord-001835-0s7ok4uw	434	39	ROS	ROS	NNP
cord-001835-0s7ok4uw	434	40	.	.	.
cord-001835-0s7ok4uw	435	1	A	a	DT
cord-001835-0s7ok4uw	435	2	solar	solar	JJ
cord-001835-0s7ok4uw	435	3	simulator	simulator	NN
cord-001835-0s7ok4uw	435	4	,	,	,
cord-001835-0s7ok4uw	435	5	with	with	IN
cord-001835-0s7ok4uw	435	6	the	the	DT
cord-001835-0s7ok4uw	435	7	flux	flux	NN
cord-001835-0s7ok4uw	435	8	output	output	NN
cord-001835-0s7ok4uw	435	9	intensity	intensity	NN
cord-001835-0s7ok4uw	435	10	of	of	IN
cord-001835-0s7ok4uw	435	11	1	1	CD
cord-001835-0s7ok4uw	435	12	kW	kW	NNP
cord-001835-0s7ok4uw	435	13	/	/	SYM
cord-001835-0s7ok4uw	435	14	m2	m2	NNP
cord-001835-0s7ok4uw	435	15	,	,	,
cord-001835-0s7ok4uw	435	16	was	be	VBD
cord-001835-0s7ok4uw	435	17	used	use	VBN
cord-001835-0s7ok4uw	435	18	as	as	IN
cord-001835-0s7ok4uw	435	19	a	a	DT
cord-001835-0s7ok4uw	435	20	visible	visible	JJ
cord-001835-0s7ok4uw	435	21	light	light	JJ
cord-001835-0s7ok4uw	435	22	source	source	NN
cord-001835-0s7ok4uw	435	23	.	.	.
cord-001835-0s7ok4uw	436	1	Electron	electron	NN
cord-001835-0s7ok4uw	436	2	spin	spin	NN
cord-001835-0s7ok4uw	436	3	resonance	resonance	NN
cord-001835-0s7ok4uw	436	4	(	(	-LRB-
cord-001835-0s7ok4uw	436	5	ESR	ESR	NNP
cord-001835-0s7ok4uw	436	6	)	)	-RRB-
cord-001835-0s7ok4uw	436	7	was	be	VBD
cord-001835-0s7ok4uw	436	8	employed	employ	VBN
cord-001835-0s7ok4uw	436	9	to	to	TO
cord-001835-0s7ok4uw	436	10	monitor	monitor	VB
cord-001835-0s7ok4uw	436	11	the	the	DT
cord-001835-0s7ok4uw	436	12	changes	change	NNS
cord-001835-0s7ok4uw	436	13	in	in	IN
cord-001835-0s7ok4uw	436	14	the	the	DT
cord-001835-0s7ok4uw	436	15	paramagnetic	paramagnetic	JJ
cord-001835-0s7ok4uw	436	16	signal	signal	NN
cord-001835-0s7ok4uw	436	17	of	of	IN
cord-001835-0s7ok4uw	436	18	TEMPOL	TEMPOL	NNP
cord-001835-0s7ok4uw	436	19	exposed	expose	VBN
cord-001835-0s7ok4uw	436	20	to	to	IN
cord-001835-0s7ok4uw	436	21	the	the	DT
cord-001835-0s7ok4uw	436	22	action	action	NN
cord-001835-0s7ok4uw	436	23	of	of	IN
cord-001835-0s7ok4uw	436	24	ROS	ROS	NNP
cord-001835-0s7ok4uw	436	25	in	in	IN
cord-001835-0s7ok4uw	436	26	the	the	DT
cord-001835-0s7ok4uw	436	27	absence	absence	NN
cord-001835-0s7ok4uw	436	28	and	and	CC
cord-001835-0s7ok4uw	436	29	presence	presence	NN
cord-001835-0s7ok4uw	436	30	of	of	IN
cord-001835-0s7ok4uw	436	31	EGFP	EGFP	NNP
cord-001835-0s7ok4uw	436	32	.	.	.
cord-001835-0s7ok4uw	437	1	In	in	IN
cord-001835-0s7ok4uw	437	2	the	the	DT
cord-001835-0s7ok4uw	437	3	absence	absence	NN
cord-001835-0s7ok4uw	437	4	of	of	IN
cord-001835-0s7ok4uw	437	5	EGFP	EGFP	NNP
cord-001835-0s7ok4uw	437	6	and	and	CC
cord-001835-0s7ok4uw	437	7	after	after	IN
cord-001835-0s7ok4uw	437	8	50	50	CD
cord-001835-0s7ok4uw	437	9	min	min	NN
cord-001835-0s7ok4uw	437	10	of	of	IN
cord-001835-0s7ok4uw	437	11	illumination	illumination	NN
cord-001835-0s7ok4uw	437	12	,	,	,
cord-001835-0s7ok4uw	437	13	due	due	IN
cord-001835-0s7ok4uw	437	14	to	to	IN
cord-001835-0s7ok4uw	437	15	a	a	DT
cord-001835-0s7ok4uw	437	16	combined	combine	VBN
cord-001835-0s7ok4uw	437	17	action	action	NN
cord-001835-0s7ok4uw	437	18	of	of	IN
cord-001835-0s7ok4uw	437	19	superoxide	superoxide	NN
cord-001835-0s7ok4uw	437	20	(	(	-LRB-
cord-001835-0s7ok4uw	437	21	O2•-	O2•-	NNPS
cord-001835-0s7ok4uw	437	22	)	)	-RRB-
cord-001835-0s7ok4uw	437	23	and	and	CC
cord-001835-0s7ok4uw	437	24	hydroxyl	hydroxyl	NN
cord-001835-0s7ok4uw	437	25	(	(	-LRB-
cord-001835-0s7ok4uw	437	26	OH•	oh•	NN
cord-001835-0s7ok4uw	437	27	)	)	-RRB-
cord-001835-0s7ok4uw	437	28	radicals	radical	NNS
cord-001835-0s7ok4uw	437	29	generated	generate	VBN
cord-001835-0s7ok4uw	437	30	by	by	IN
cord-001835-0s7ok4uw	437	31	the	the	DT
cord-001835-0s7ok4uw	437	32	system	system	NN
cord-001835-0s7ok4uw	437	33	'	'	''
cord-001835-0s7ok4uw	437	34	N	N	NNP
cord-001835-0s7ok4uw	437	35	-	-	HYPH
cord-001835-0s7ok4uw	437	36	doped	dope	VBN
cord-001835-0s7ok4uw	437	37	nano	nano	NN
cord-001835-0s7ok4uw	437	38	-	-	HYPH
cord-001835-0s7ok4uw	437	39	TiO2)/visible	tio2)/visible	JJ
cord-001835-0s7ok4uw	437	40	light	light	NN
cord-001835-0s7ok4uw	437	41	,	,	,
cord-001835-0s7ok4uw	437	42	the	the	DT
cord-001835-0s7ok4uw	437	43	ESR	ESR	NNP
cord-001835-0s7ok4uw	437	44	signal	signal	NN
cord-001835-0s7ok4uw	437	45	of	of	IN
cord-001835-0s7ok4uw	437	46	100	100	CD
cord-001835-0s7ok4uw	437	47	uM	um	UH
cord-001835-0s7ok4uw	437	48	TEMPOL	TEMPOL	NNP
cord-001835-0s7ok4uw	437	49	decayed	decay	VBN
cord-001835-0s7ok4uw	437	50	by	by	IN
cord-001835-0s7ok4uw	437	51	20	20	CD
cord-001835-0s7ok4uw	437	52	%	%	NN
cord-001835-0s7ok4uw	437	53	.	.	.
cord-001835-0s7ok4uw	438	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	438	2	,	,	,
cord-001835-0s7ok4uw	438	3	the	the	DT
cord-001835-0s7ok4uw	438	4	growth	growth	NN
cord-001835-0s7ok4uw	438	5	of	of	IN
cord-001835-0s7ok4uw	438	6	a	a	DT
cord-001835-0s7ok4uw	438	7	new	new	JJ
cord-001835-0s7ok4uw	438	8	signal	signal	NN
cord-001835-0s7ok4uw	438	9	,	,	,
cord-001835-0s7ok4uw	438	10	interpreted	interpret	VBD
cord-001835-0s7ok4uw	438	11	as	as	IN
cord-001835-0s7ok4uw	438	12	4-oxo-2,2,6,6-tetramethyl-1-piperidinyloxy	4-oxo-2,2,6,6-tetramethyl-1-piperidinyloxy	CD
cord-001835-0s7ok4uw	438	13	(	(	-LRB-
cord-001835-0s7ok4uw	438	14	TEMPONE	TEMPONE	NNP
cord-001835-0s7ok4uw	438	15	)	)	-RRB-
cord-001835-0s7ok4uw	438	16	,	,	,
cord-001835-0s7ok4uw	438	17	resulting	result	VBG
cord-001835-0s7ok4uw	438	18	from	from	IN
cord-001835-0s7ok4uw	438	19	the	the	DT
cord-001835-0s7ok4uw	438	20	attack	attack	NN
cord-001835-0s7ok4uw	438	21	of	of	IN
cord-001835-0s7ok4uw	438	22	OH•radicals	oh•radical	NNS
cord-001835-0s7ok4uw	438	23	on	on	IN
cord-001835-0s7ok4uw	438	24	TEMPOL	TEMPOL	NNP
cord-001835-0s7ok4uw	438	25	,	,	,
cord-001835-0s7ok4uw	438	26	was	be	VBD
cord-001835-0s7ok4uw	438	27	also	also	RB
cord-001835-0s7ok4uw	438	28	observed	observe	VBN
cord-001835-0s7ok4uw	438	29	.	.	.
cord-001835-0s7ok4uw	439	1	In	in	IN
cord-001835-0s7ok4uw	439	2	contrast	contrast	NN
cord-001835-0s7ok4uw	439	3	,	,	,
cord-001835-0s7ok4uw	439	4	in	in	IN
cord-001835-0s7ok4uw	439	5	the	the	DT
cord-001835-0s7ok4uw	439	6	presence	presence	NN
cord-001835-0s7ok4uw	439	7	of	of	IN
cord-001835-0s7ok4uw	439	8	EGFP	EGFP	NNP
cord-001835-0s7ok4uw	439	9	(	(	-LRB-
cord-001835-0s7ok4uw	439	10	7.5	7.5	CD
cord-001835-0s7ok4uw	439	11	uM	um	UH
cord-001835-0s7ok4uw	439	12	)	)	-RRB-
cord-001835-0s7ok4uw	439	13	,	,	,
cord-001835-0s7ok4uw	439	14	the	the	DT
cord-001835-0s7ok4uw	439	15	ROS	ROS	NNP
cord-001835-0s7ok4uw	439	16	-	-	HYPH
cord-001835-0s7ok4uw	439	17	induced	induce	VBN
cord-001835-0s7ok4uw	439	18	decay	decay	NN
cord-001835-0s7ok4uw	439	19	of	of	IN
cord-001835-0s7ok4uw	439	20	the	the	DT
cord-001835-0s7ok4uw	439	21	ESR	ESR	NNP
cord-001835-0s7ok4uw	439	22	signal	signal	NN
cord-001835-0s7ok4uw	439	23	of	of	IN
cord-001835-0s7ok4uw	439	24	TEMPOL	TEMPOL	NNP
cord-001835-0s7ok4uw	439	25	was	be	VBD
cord-001835-0s7ok4uw	439	26	markedly	markedly	RB
cord-001835-0s7ok4uw	439	27	smaller	small	JJR
cord-001835-0s7ok4uw	439	28	,	,	,
cord-001835-0s7ok4uw	439	29	not	not	RB
cord-001835-0s7ok4uw	439	30	exceeding	exceed	VBG
cord-001835-0s7ok4uw	439	31	5	5	CD
cord-001835-0s7ok4uw	439	32	%	%	NN
cord-001835-0s7ok4uw	439	33	.	.	.
cord-001835-0s7ok4uw	440	1	Concomitantly	concomitantly	RB
cord-001835-0s7ok4uw	440	2	,	,	,
cord-001835-0s7ok4uw	440	3	the	the	DT
cord-001835-0s7ok4uw	440	4	growth	growth	NN
cord-001835-0s7ok4uw	440	5	of	of	IN
cord-001835-0s7ok4uw	440	6	the	the	DT
cord-001835-0s7ok4uw	440	7	ESR	ESR	NNP
cord-001835-0s7ok4uw	440	8	signal	signal	NN
cord-001835-0s7ok4uw	440	9	of	of	IN
cord-001835-0s7ok4uw	440	10	TEMPONE	TEMPONE	NNP
cord-001835-0s7ok4uw	440	11	was	be	VBD
cord-001835-0s7ok4uw	440	12	also	also	RB
cord-001835-0s7ok4uw	440	13	partially	partially	RB
cord-001835-0s7ok4uw	440	14	inhibited	inhibit	VBN
cord-001835-0s7ok4uw	440	15	(	(	-LRB-
cord-001835-0s7ok4uw	440	16	30	30	CD
cord-001835-0s7ok4uw	440	17	%	%	NN
cord-001835-0s7ok4uw	440	18	smaller	small	JJR
cord-001835-0s7ok4uw	440	19	amplitude	amplitude	NN
cord-001835-0s7ok4uw	440	20	)	)	-RRB-
cord-001835-0s7ok4uw	440	21	,	,	,
cord-001835-0s7ok4uw	440	22	as	as	IN
cord-001835-0s7ok4uw	440	23	compared	compare	VBN
cord-001835-0s7ok4uw	440	24	to	to	IN
cord-001835-0s7ok4uw	440	25	the	the	DT
cord-001835-0s7ok4uw	440	26	process	process	NN
cord-001835-0s7ok4uw	440	27	performed	perform	VBN
cord-001835-0s7ok4uw	440	28	in	in	IN
cord-001835-0s7ok4uw	440	29	the	the	DT
cord-001835-0s7ok4uw	440	30	absence	absence	NN
cord-001835-0s7ok4uw	440	31	of	of	IN
cord-001835-0s7ok4uw	440	32	EGFP	EGFP	NNP
cord-001835-0s7ok4uw	440	33	.	.	.
cord-001835-0s7ok4uw	441	1	In	in	IN
cord-001835-0s7ok4uw	441	2	summary	summary	NN
cord-001835-0s7ok4uw	441	3	,	,	,
cord-001835-0s7ok4uw	441	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	441	5	results	result	NNS
cord-001835-0s7ok4uw	441	6	point	point	VBP
cord-001835-0s7ok4uw	441	7	to	to	IN
cord-001835-0s7ok4uw	441	8	a	a	DT
cord-001835-0s7ok4uw	441	9	significant	significant	JJ
cord-001835-0s7ok4uw	441	10	inhibition	inhibition	NN
cord-001835-0s7ok4uw	441	11	of	of	IN
cord-001835-0s7ok4uw	441	12	the	the	DT
cord-001835-0s7ok4uw	441	13	photodecomposition	photodecomposition	NN
cord-001835-0s7ok4uw	441	14	of	of	IN
cord-001835-0s7ok4uw	441	15	TEMPOL	TEMPOL	NNP
cord-001835-0s7ok4uw	441	16	in	in	IN
cord-001835-0s7ok4uw	441	17	the	the	DT
cord-001835-0s7ok4uw	441	18	presence	presence	NN
cord-001835-0s7ok4uw	441	19	of	of	IN
cord-001835-0s7ok4uw	441	20	EGFP	EGFP	NNP
cord-001835-0s7ok4uw	441	21	and	and	CC
cord-001835-0s7ok4uw	441	22	support	support	VB
cord-001835-0s7ok4uw	441	23	the	the	DT
cord-001835-0s7ok4uw	441	24	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	441	25	of	of	IN
cord-001835-0s7ok4uw	441	26	the	the	DT
cord-001835-0s7ok4uw	441	27	protective	protective	JJ
cord-001835-0s7ok4uw	441	28	role	role	NN
cord-001835-0s7ok4uw	441	29	of	of	IN
cord-001835-0s7ok4uw	441	30	this	this	DT
cord-001835-0s7ok4uw	441	31	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	441	32	protein	protein	NN
cord-001835-0s7ok4uw	441	33	against	against	IN
cord-001835-0s7ok4uw	441	34	ROS	ROS	NNP
cord-001835-0s7ok4uw	441	35	generated	generate	VBN
cord-001835-0s7ok4uw	441	36	by	by	IN
cord-001835-0s7ok4uw	441	37	the	the	DT
cord-001835-0s7ok4uw	441	38	system	system	NN
cord-001835-0s7ok4uw	441	39	'	'	''
cord-001835-0s7ok4uw	441	40	N	N	NNP
cord-001835-0s7ok4uw	441	41	-	-	HYPH
cord-001835-0s7ok4uw	441	42	doped	dope	VBN
cord-001835-0s7ok4uw	441	43	nano	nano	NN
cord-001835-0s7ok4uw	441	44	-	-	HYPH
cord-001835-0s7ok4uw	441	45	TiO2)/visible	tio2)/visible	JJ
cord-001835-0s7ok4uw	441	46	light	light	NN
cord-001835-0s7ok4uw	441	47	'	'	''
cord-001835-0s7ok4uw	441	48	.	.	.
cord-001835-0s7ok4uw	442	1	School	school	NN
cord-001835-0s7ok4uw	442	2	of	of	IN
cord-001835-0s7ok4uw	442	3	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	442	4	,	,	,
cord-001835-0s7ok4uw	442	5	National	National	NNP
cord-001835-0s7ok4uw	442	6	University	University	NNP
cord-001835-0s7ok4uw	442	7	of	of	IN
cord-001835-0s7ok4uw	442	8	Ireland	Ireland	NNP
cord-001835-0s7ok4uw	442	9	Galway	Galway	NNP
cord-001835-0s7ok4uw	442	10	,	,	,
cord-001835-0s7ok4uw	442	11	2	2	CD
cord-001835-0s7ok4uw	442	12	School	School	NNP
cord-001835-0s7ok4uw	442	13	of	of	IN
cord-001835-0s7ok4uw	442	14	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	442	15	and	and	CC
cord-001835-0s7ok4uw	442	16	Immunology	Immunology	NNP
cord-001835-0s7ok4uw	442	17	,	,	,
cord-001835-0s7ok4uw	442	18	Trinity	Trinity	NNP
cord-001835-0s7ok4uw	442	19	College	College	NNP
cord-001835-0s7ok4uw	442	20	Dublin	Dublin	NNP
cord-001835-0s7ok4uw	443	1	By	by	IN
cord-001835-0s7ok4uw	443	2	studying	study	VBG
cord-001835-0s7ok4uw	443	3	a	a	DT
cord-001835-0s7ok4uw	443	4	variety	variety	NN
cord-001835-0s7ok4uw	443	5	of	of	IN
cord-001835-0s7ok4uw	443	6	anionic	anionic	JJ
cord-001835-0s7ok4uw	443	7	ligands	ligand	NNS
cord-001835-0s7ok4uw	443	8	and	and	CC
cord-001835-0s7ok4uw	443	9	their	-PRON-	PRP$
cord-001835-0s7ok4uw	443	10	interactions	interaction	NNS
cord-001835-0s7ok4uw	443	11	with	with	IN
cord-001835-0s7ok4uw	443	12	cationic	cationic	JJ
cord-001835-0s7ok4uw	443	13	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	443	14	c	c	NN
cord-001835-0s7ok4uw	443	15	,	,	,
cord-001835-0s7ok4uw	443	16	we	-PRON-	PRP
cord-001835-0s7ok4uw	443	17	are	be	VBP
cord-001835-0s7ok4uw	443	18	building	build	VBG
cord-001835-0s7ok4uw	443	19	knowledge	knowledge	NN
cord-001835-0s7ok4uw	443	20	of	of	IN
cord-001835-0s7ok4uw	443	21	protein	protein	NN
cord-001835-0s7ok4uw	443	22	recognition	recognition	NN
cord-001835-0s7ok4uw	443	23	geared	gear	VBN
cord-001835-0s7ok4uw	443	24	towards	towards	IN
cord-001835-0s7ok4uw	443	25	regulating	regulate	VBG
cord-001835-0s7ok4uw	443	26	activity	activity	NN
cord-001835-0s7ok4uw	443	27	.	.	.
cord-001835-0s7ok4uw	444	1	In	in	IN
cord-001835-0s7ok4uw	444	2	previous	previous	JJ
cord-001835-0s7ok4uw	444	3	work	work	NN
cord-001835-0s7ok4uw	444	4	it	-PRON-	PRP
cord-001835-0s7ok4uw	444	5	was	be	VBD
cord-001835-0s7ok4uw	444	6	shown	show	VBN
cord-001835-0s7ok4uw	444	7	that	that	IN
cord-001835-0s7ok4uw	444	8	psulfonatocalix	psulfonatocalix	NNP
cord-001835-0s7ok4uw	444	9	[	[	-LRB-
cord-001835-0s7ok4uw	444	10	4	4	CD
cord-001835-0s7ok4uw	444	11	]	]	-RRB-
cord-001835-0s7ok4uw	444	12	arene	arene	NNP
cord-001835-0s7ok4uw	444	13	selectively	selectively	RB
cord-001835-0s7ok4uw	444	14	binds	bind	VBZ
cord-001835-0s7ok4uw	444	15	to	to	IN
cord-001835-0s7ok4uw	444	16	,	,	,
cord-001835-0s7ok4uw	444	17	and	and	CC
cord-001835-0s7ok4uw	444	18	encapsulates	encapsulate	VBZ
cord-001835-0s7ok4uw	444	19	,	,	,
cord-001835-0s7ok4uw	444	20	three	three	CD
cord-001835-0s7ok4uw	444	21	Lysine	lysine	NN
cord-001835-0s7ok4uw	444	22	side	side	NN
cord-001835-0s7ok4uw	444	23	chains	chain	NNS
cord-001835-0s7ok4uw	444	24	on	on	IN
cord-001835-0s7ok4uw	444	25	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	444	26	c	c	NN
cord-001835-0s7ok4uw	444	27	1	1	CD
cord-001835-0s7ok4uw	444	28	.	.	.
cord-001835-0s7ok4uw	445	1	Here	here	RB
cord-001835-0s7ok4uw	445	2	,	,	,
cord-001835-0s7ok4uw	445	3	the	the	DT
cord-001835-0s7ok4uw	445	4	binding	binding	NN
cord-001835-0s7ok4uw	445	5	of	of	IN
cord-001835-0s7ok4uw	445	6	two	two	CD
cord-001835-0s7ok4uw	445	7	small	small	JJ
cord-001835-0s7ok4uw	445	8	molecule	molecule	NN
cord-001835-0s7ok4uw	445	9	ligands	ligand	NNS
cord-001835-0s7ok4uw	445	10	to	to	IN
cord-001835-0s7ok4uw	445	11	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	445	12	c	c	NN
cord-001835-0s7ok4uw	445	13	was	be	VBD
cord-001835-0s7ok4uw	445	14	investigated	investigate	VBN
cord-001835-0s7ok4uw	445	15	.	.	.
cord-001835-0s7ok4uw	446	1	NMR	NMR	NNP
cord-001835-0s7ok4uw	446	2	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	446	3	was	be	VBD
cord-001835-0s7ok4uw	446	4	used	use	VBN
cord-001835-0s7ok4uw	446	5	and	and	CC
cord-001835-0s7ok4uw	446	6	in	in	IN
cord-001835-0s7ok4uw	446	7	one	one	CD
cord-001835-0s7ok4uw	446	8	case	case	NN
cord-001835-0s7ok4uw	446	9	,	,	,
cord-001835-0s7ok4uw	446	10	a	a	DT
cord-001835-0s7ok4uw	446	11	crystal	crystal	NN
cord-001835-0s7ok4uw	446	12	structure	structure	NN
cord-001835-0s7ok4uw	446	13	of	of	IN
cord-001835-0s7ok4uw	446	14	the	the	DT
cord-001835-0s7ok4uw	446	15	complex	complex	NN
cord-001835-0s7ok4uw	446	16	was	be	VBD
cord-001835-0s7ok4uw	446	17	obtained	obtain	VBN
cord-001835-0s7ok4uw	446	18	(	(	-LRB-
cord-001835-0s7ok4uw	446	19	Fig	Fig	NNP
cord-001835-0s7ok4uw	446	20	1	1	CD
cord-001835-0s7ok4uw	446	21	)	)	-RRB-
cord-001835-0s7ok4uw	446	22	.	.	.
cord-001835-0s7ok4uw	447	1	The	the	DT
cord-001835-0s7ok4uw	447	2	calixarene	calixarene	NN
cord-001835-0s7ok4uw	447	3	bound	bind	VBN
cord-001835-0s7ok4uw	447	4	to	to	IN
cord-001835-0s7ok4uw	447	5	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	447	6	c	c	NN
cord-001835-0s7ok4uw	447	7	,	,	,
cord-001835-0s7ok4uw	447	8	reveals	reveal	VBZ
cord-001835-0s7ok4uw	447	9	a	a	DT
cord-001835-0s7ok4uw	447	10	crystal	crystal	NN
cord-001835-0s7ok4uw	447	11	packing	packing	NN
cord-001835-0s7ok4uw	447	12	assembly	assembly	NN
cord-001835-0s7ok4uw	447	13	that	that	WDT
cord-001835-0s7ok4uw	447	14	suggests	suggest	VBZ
cord-001835-0s7ok4uw	447	15	it	-PRON-	PRP
cord-001835-0s7ok4uw	447	16	is	be	VBZ
cord-001835-0s7ok4uw	447	17	a	a	DT
cord-001835-0s7ok4uw	447	18	key	key	JJ
cord-001835-0s7ok4uw	447	19	mediator	mediator	NN
cord-001835-0s7ok4uw	447	20	of	of	IN
cord-001835-0s7ok4uw	447	21	crystal	crystal	NN
cord-001835-0s7ok4uw	447	22	formation	formation	NN
cord-001835-0s7ok4uw	447	23	.	.	.
cord-001835-0s7ok4uw	448	1	NMR	NMR	NNP
cord-001835-0s7ok4uw	448	2	data	data	NN
cord-001835-0s7ok4uw	448	3	analysis	analysis	NN
cord-001835-0s7ok4uw	448	4	indicates	indicate	VBZ
cord-001835-0s7ok4uw	448	5	the	the	DT
cord-001835-0s7ok4uw	448	6	calixarene	calixarene	NN
cord-001835-0s7ok4uw	448	7	's	's	POS
cord-001835-0s7ok4uw	448	8	binding	binding	NN
cord-001835-0s7ok4uw	448	9	site	site	NN
cord-001835-0s7ok4uw	448	10	on	on	IN
cord-001835-0s7ok4uw	448	11	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	448	12	c.	c.	NN
cord-001835-0s7ok4uw	449	1	The	the	DT
cord-001835-0s7ok4uw	449	2	pillararene	pillararene	NN
cord-001835-0s7ok4uw	449	3	,	,	,
cord-001835-0s7ok4uw	449	4	a	a	DT
cord-001835-0s7ok4uw	449	5	relatively	relatively	RB
cord-001835-0s7ok4uw	449	6	new	new	JJ
cord-001835-0s7ok4uw	449	7	class	class	NN
cord-001835-0s7ok4uw	449	8	of	of	IN
cord-001835-0s7ok4uw	449	9	compound	compound	NN
cord-001835-0s7ok4uw	449	10	,	,	,
cord-001835-0s7ok4uw	449	11	is	be	VBZ
cord-001835-0s7ok4uw	449	12	a	a	DT
cord-001835-0s7ok4uw	449	13	symmetrical	symmetrical	JJ
cord-001835-0s7ok4uw	449	14	arrangement	arrangement	NN
cord-001835-0s7ok4uw	449	15	with	with	IN
cord-001835-0s7ok4uw	449	16	a	a	DT
cord-001835-0s7ok4uw	449	17	p	p	XX
cord-001835-0s7ok4uw	449	18	-	-	HYPH
cord-001835-0s7ok4uw	449	19	rich	rich	JJ
cord-001835-0s7ok4uw	449	20	cavity	cavity	NN
cord-001835-0s7ok4uw	449	21	2	2	CD
cord-001835-0s7ok4uw	449	22	,	,	,
cord-001835-0s7ok4uw	449	23	related	relate	VBN
cord-001835-0s7ok4uw	449	24	structurally	structurally	RB
cord-001835-0s7ok4uw	449	25	to	to	IN
cord-001835-0s7ok4uw	449	26	calixarenes	calixarene	NNS
cord-001835-0s7ok4uw	449	27	.	.	.
cord-001835-0s7ok4uw	450	1	This	this	DT
cord-001835-0s7ok4uw	450	2	suggests	suggest	VBZ
cord-001835-0s7ok4uw	450	3	good	good	JJ
cord-001835-0s7ok4uw	450	4	host	host	NN
cord-001835-0s7ok4uw	450	5	-	-	HYPH
cord-001835-0s7ok4uw	450	6	guest	guest	NN
cord-001835-0s7ok4uw	450	7	complexation	complexation	NN
cord-001835-0s7ok4uw	450	8	properties	property	NNS
cord-001835-0s7ok4uw	450	9	.	.	.
cord-001835-0s7ok4uw	451	1	Previously	previously	RB
cord-001835-0s7ok4uw	451	2	,	,	,
cord-001835-0s7ok4uw	451	3	the	the	DT
cord-001835-0s7ok4uw	451	4	carboxylatopillararene	carboxylatopillararene	NN
cord-001835-0s7ok4uw	451	5	showed	show	VBD
cord-001835-0s7ok4uw	451	6	selective	selective	JJ
cord-001835-0s7ok4uw	451	7	binding	binding	NN
cord-001835-0s7ok4uw	451	8	to	to	IN
cord-001835-0s7ok4uw	451	9	Arginine	arginine	NN
cord-001835-0s7ok4uw	451	10	,	,	,
cord-001835-0s7ok4uw	451	11	Lysine	Lysine	NNP
cord-001835-0s7ok4uw	451	12	and	and	CC
cord-001835-0s7ok4uw	451	13	Histidine	Histidine	NNP
cord-001835-0s7ok4uw	451	14	2	2	CD
cord-001835-0s7ok4uw	451	15	.	.	.
cord-001835-0s7ok4uw	452	1	With	with	IN
cord-001835-0s7ok4uw	452	2	this	this	DT
cord-001835-0s7ok4uw	452	3	ligand	ligand	NN
cord-001835-0s7ok4uw	452	4	,	,	,
cord-001835-0s7ok4uw	452	5	an	an	DT
cord-001835-0s7ok4uw	452	6	interaction	interaction	NN
cord-001835-0s7ok4uw	452	7	with	with	IN
cord-001835-0s7ok4uw	452	8	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	452	9	c	c	NN
cord-001835-0s7ok4uw	452	10	was	be	VBD
cord-001835-0s7ok4uw	452	11	observed	observe	VBN
cord-001835-0s7ok4uw	452	12	and	and	CC
cord-001835-0s7ok4uw	452	13	a	a	DT
cord-001835-0s7ok4uw	452	14	complex	complex	NN
cord-001835-0s7ok4uw	452	15	formed	form	VBN
cord-001835-0s7ok4uw	452	16	.	.	.
cord-001835-0s7ok4uw	453	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	453	2	,	,	,
cord-001835-0s7ok4uw	453	3	biphasic	biphasic	JJ
cord-001835-0s7ok4uw	453	4	binding	binding	NN
cord-001835-0s7ok4uw	453	5	behaviour	behaviour	NN
cord-001835-0s7ok4uw	453	6	was	be	VBD
cord-001835-0s7ok4uw	453	7	observed	observe	VBN
cord-001835-0s7ok4uw	453	8	through	through	IN
cord-001835-0s7ok4uw	453	9	analysis	analysis	NN
cord-001835-0s7ok4uw	453	10	of	of	IN
cord-001835-0s7ok4uw	453	11	the	the	DT
cord-001835-0s7ok4uw	453	12	chemical	chemical	JJ
cord-001835-0s7ok4uw	453	13	shift	shift	NN
cord-001835-0s7ok4uw	453	14	perturbations	perturbation	NNS
cord-001835-0s7ok4uw	453	15	.	.	.
cord-001835-0s7ok4uw	454	1	This	this	DT
cord-001835-0s7ok4uw	454	2	may	may	MD
cord-001835-0s7ok4uw	454	3	indicate	indicate	VB
cord-001835-0s7ok4uw	454	4	more	more	JJR
cord-001835-0s7ok4uw	454	5	than	than	IN
cord-001835-0s7ok4uw	454	6	one	one	CD
cord-001835-0s7ok4uw	454	7	binding	bind	VBG
cord-001835-0s7ok4uw	454	8	event	event	NN
cord-001835-0s7ok4uw	454	9	taking	take	VBG
cord-001835-0s7ok4uw	454	10	place	place	NN
cord-001835-0s7ok4uw	454	11	.	.	.
cord-001835-0s7ok4uw	455	1	The	the	DT
cord-001835-0s7ok4uw	455	2	data	datum	NNS
cord-001835-0s7ok4uw	455	3	from	from	IN
cord-001835-0s7ok4uw	455	4	these	these	DT
cord-001835-0s7ok4uw	455	5	studies	study	NNS
cord-001835-0s7ok4uw	455	6	indicate	indicate	VBP
cord-001835-0s7ok4uw	455	7	that	that	IN
cord-001835-0s7ok4uw	455	8	recognition	recognition	NN
cord-001835-0s7ok4uw	455	9	is	be	VBZ
cord-001835-0s7ok4uw	455	10	occurring	occur	VBG
cord-001835-0s7ok4uw	455	11	and	and	CC
cord-001835-0s7ok4uw	455	12	again	again	RB
cord-001835-0s7ok4uw	455	13	that	that	IN
cord-001835-0s7ok4uw	455	14	Lysine	lysine	NN
cord-001835-0s7ok4uw	455	15	side	side	NN
cord-001835-0s7ok4uw	455	16	chains	chain	NNS
cord-001835-0s7ok4uw	455	17	play	play	VBP
cord-001835-0s7ok4uw	455	18	an	an	DT
cord-001835-0s7ok4uw	455	19	essential	essential	JJ
cord-001835-0s7ok4uw	455	20	role	role	NN
cord-001835-0s7ok4uw	455	21	.	.	.
cord-001835-0s7ok4uw	456	1	The	the	DT
cord-001835-0s7ok4uw	456	2	enzyme	enzyme	NN
cord-001835-0s7ok4uw	456	3	dihydrofolate	dihydrofolate	NN
cord-001835-0s7ok4uw	456	4	reductase	reductase	NN
cord-001835-0s7ok4uw	456	5	(	(	-LRB-
cord-001835-0s7ok4uw	456	6	DHFR	DHFR	NNP
cord-001835-0s7ok4uw	456	7	)	)	-RRB-
cord-001835-0s7ok4uw	457	1	is	be	VBZ
cord-001835-0s7ok4uw	457	2	necessary	necessary	JJ
cord-001835-0s7ok4uw	457	3	for	for	IN
cord-001835-0s7ok4uw	457	4	the	the	DT
cord-001835-0s7ok4uw	457	5	growth	growth	NN
cord-001835-0s7ok4uw	457	6	and	and	CC
cord-001835-0s7ok4uw	457	7	development	development	NN
cord-001835-0s7ok4uw	457	8	of	of	IN
cord-001835-0s7ok4uw	457	9	all	all	DT
cord-001835-0s7ok4uw	457	10	organisms	organism	NNS
cord-001835-0s7ok4uw	457	11	.	.	.
cord-001835-0s7ok4uw	458	1	1	1	LS
cord-001835-0s7ok4uw	459	1	The	the	DT
cord-001835-0s7ok4uw	459	2	structure	structure	NN
cord-001835-0s7ok4uw	459	3	and	and	CC
cord-001835-0s7ok4uw	459	4	function	function	NN
cord-001835-0s7ok4uw	459	5	of	of	IN
cord-001835-0s7ok4uw	459	6	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	459	7	coli	coli	VBZ
cord-001835-0s7ok4uw	459	8	DHFR	DHFR	NNS
cord-001835-0s7ok4uw	459	9	have	have	VBP
cord-001835-0s7ok4uw	459	10	been	be	VBN
cord-001835-0s7ok4uw	459	11	characterized	characterize	VBN
cord-001835-0s7ok4uw	459	12	in	in	IN
cord-001835-0s7ok4uw	459	13	buffer	buffer	NN
cord-001835-0s7ok4uw	459	14	.	.	.
cord-001835-0s7ok4uw	460	1	However	however	RB
cord-001835-0s7ok4uw	460	2	,	,	,
cord-001835-0s7ok4uw	460	3	DHFR	DHFR	NNP
cord-001835-0s7ok4uw	460	4	exists	exist	VBZ
cord-001835-0s7ok4uw	460	5	in	in	IN
cord-001835-0s7ok4uw	460	6	living	living	NN
cord-001835-0s7ok4uw	460	7	cells	cell	NNS
cord-001835-0s7ok4uw	460	8	,	,	,
cord-001835-0s7ok4uw	460	9	where	where	WRB
cord-001835-0s7ok4uw	460	10	the	the	DT
cord-001835-0s7ok4uw	460	11	protein	protein	NN
cord-001835-0s7ok4uw	460	12	concentration	concentration	NN
cord-001835-0s7ok4uw	460	13	can	can	MD
cord-001835-0s7ok4uw	460	14	exceed	exceed	VB
cord-001835-0s7ok4uw	460	15	300	300	CD
cord-001835-0s7ok4uw	460	16	g	g	NN
cord-001835-0s7ok4uw	460	17	/	/	SYM
cord-001835-0s7ok4uw	460	18	L.	L.	NNP
cord-001835-0s7ok4uw	460	19	2	2	CD
cord-001835-0s7ok4uw	461	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	461	2	know	know	VBP
cord-001835-0s7ok4uw	461	3	that	that	IN
cord-001835-0s7ok4uw	461	4	weak	weak	JJ
cord-001835-0s7ok4uw	461	5	,	,	,
cord-001835-0s7ok4uw	461	6	non	non	JJ
cord-001835-0s7ok4uw	461	7	-	-	JJ
cord-001835-0s7ok4uw	461	8	specific	specific	JJ
cord-001835-0s7ok4uw	461	9	chemical	chemical	JJ
cord-001835-0s7ok4uw	461	10	interactions	interaction	NNS
cord-001835-0s7ok4uw	461	11	with	with	IN
cord-001835-0s7ok4uw	461	12	cytosolic	cytosolic	JJ
cord-001835-0s7ok4uw	461	13	proteins	protein	NNS
cord-001835-0s7ok4uw	461	14	alter	alter	VBP
cord-001835-0s7ok4uw	461	15	protein	protein	NN
cord-001835-0s7ok4uw	461	16	conformation	conformation	NN
cord-001835-0s7ok4uw	461	17	and	and	CC
cord-001835-0s7ok4uw	461	18	dynamics,3,4	dynamics,3,4	NN
cord-001835-0s7ok4uw	461	19	both	both	DT
cord-001835-0s7ok4uw	461	20	of	of	IN
cord-001835-0s7ok4uw	461	21	which	which	WDT
cord-001835-0s7ok4uw	461	22	are	be	VBP
cord-001835-0s7ok4uw	461	23	expected	expect	VBN
cord-001835-0s7ok4uw	461	24	to	to	TO
cord-001835-0s7ok4uw	461	25	influence	influence	VB
cord-001835-0s7ok4uw	461	26	DHFR	DHFR	NNP
cord-001835-0s7ok4uw	461	27	catalysis	catalysis	NN
cord-001835-0s7ok4uw	461	28	.	.	.
cord-001835-0s7ok4uw	462	1	Investigators	investigator	NNS
cord-001835-0s7ok4uw	462	2	have	have	VBP
cord-001835-0s7ok4uw	462	3	examined	examine	VBN
cord-001835-0s7ok4uw	462	4	steady	steady	JJ
cord-001835-0s7ok4uw	462	5	-	-	HYPH
cord-001835-0s7ok4uw	462	6	state	state	NN
cord-001835-0s7ok4uw	462	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	462	8	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	462	9	under	under	IN
cord-001835-0s7ok4uw	462	10	crowded	crowded	JJ
cord-001835-0s7ok4uw	462	11	conditions	condition	NNS
cord-001835-0s7ok4uw	462	12	,	,	,
cord-001835-0s7ok4uw	462	13	but	but	CC
cord-001835-0s7ok4uw	462	14	conclusions	conclusion	NNS
cord-001835-0s7ok4uw	462	15	can	can	MD
cord-001835-0s7ok4uw	462	16	be	be	VB
cord-001835-0s7ok4uw	462	17	conflicting	conflict	VBG
cord-001835-0s7ok4uw	462	18	.	.	.
cord-001835-0s7ok4uw	463	1	5	5	CD
cord-001835-0s7ok4uw	463	2	,	,	,
cord-001835-0s7ok4uw	463	3	6	6	CD
cord-001835-0s7ok4uw	464	1	Here	here	RB
cord-001835-0s7ok4uw	464	2	,	,	,
cord-001835-0s7ok4uw	464	3	the	the	DT
cord-001835-0s7ok4uw	464	4	effects	effect	NNS
cord-001835-0s7ok4uw	464	5	of	of	IN
cord-001835-0s7ok4uw	464	6	crowding	crowd	VBG
cord-001835-0s7ok4uw	464	7	on	on	IN
cord-001835-0s7ok4uw	464	8	E.	E.	NNP
cord-001835-0s7ok4uw	464	9	coli	coli	VBZ
cord-001835-0s7ok4uw	464	10	DHFR	DHFR	NNP
cord-001835-0s7ok4uw	464	11	catalysis	catalysis	NN
cord-001835-0s7ok4uw	464	12	are	be	VBP
cord-001835-0s7ok4uw	464	13	assessed	assess	VBN
cord-001835-0s7ok4uw	464	14	through	through	IN
cord-001835-0s7ok4uw	464	15	specific	specific	JJ
cord-001835-0s7ok4uw	464	16	activity	activity	NN
cord-001835-0s7ok4uw	464	17	measurements	measurement	NNS
cord-001835-0s7ok4uw	464	18	in	in	IN
cord-001835-0s7ok4uw	464	19	solutions	solution	NNS
cord-001835-0s7ok4uw	464	20	of	of	IN
cord-001835-0s7ok4uw	464	21	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	464	22	polymers	polymer	NNS
cord-001835-0s7ok4uw	464	23	.	.	.
cord-001835-0s7ok4uw	465	1	These	these	DT
cord-001835-0s7ok4uw	465	2	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	465	3	studies	study	NNS
cord-001835-0s7ok4uw	465	4	are	be	VBP
cord-001835-0s7ok4uw	465	5	complemented	complement	VBN
cord-001835-0s7ok4uw	465	6	by	by	IN
cord-001835-0s7ok4uw	465	7	in	in	IN
cord-001835-0s7ok4uw	465	8	-	-	HYPH
cord-001835-0s7ok4uw	465	9	cell	cell	NN
cord-001835-0s7ok4uw	465	10	and	and	CC
cord-001835-0s7ok4uw	465	11	in	in	IN
cord-001835-0s7ok4uw	465	12	vitro	vitro	FW
cord-001835-0s7ok4uw	465	13	19F	19F	NNP
cord-001835-0s7ok4uw	465	14	NMR	NMR	NNP
cord-001835-0s7ok4uw	465	15	data	datum	NNS
cord-001835-0s7ok4uw	465	16	from	from	IN
cord-001835-0s7ok4uw	465	17	fluorinated	fluorinated	JJ
cord-001835-0s7ok4uw	465	18	tryptophan	tryptophan	NN
cord-001835-0s7ok4uw	465	19	residues	residue	NNS
cord-001835-0s7ok4uw	465	20	.	.	.
cord-001835-0s7ok4uw	466	1	Preliminary	preliminary	JJ
cord-001835-0s7ok4uw	466	2	results	result	NNS
cord-001835-0s7ok4uw	466	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	466	4	that	that	IN
cord-001835-0s7ok4uw	466	5	the	the	DT
cord-001835-0s7ok4uw	466	6	effects	effect	NNS
cord-001835-0s7ok4uw	466	7	of	of	IN
cord-001835-0s7ok4uw	466	8	polymeric	polymeric	JJ
cord-001835-0s7ok4uw	466	9	crowders	crowder	NNS
cord-001835-0s7ok4uw	466	10	on	on	IN
cord-001835-0s7ok4uw	466	11	DHFR	DHFR	NNP
cord-001835-0s7ok4uw	466	12	activity	activity	NN
cord-001835-0s7ok4uw	466	13	are	be	VBP
cord-001835-0s7ok4uw	466	14	non	non	JJ
cord-001835-0s7ok4uw	466	15	-	-	JJ
cord-001835-0s7ok4uw	466	16	monotonic	monotonic	JJ
cord-001835-0s7ok4uw	466	17	,	,	,
cord-001835-0s7ok4uw	466	18	which	which	WDT
cord-001835-0s7ok4uw	466	19	may	may	MD
cord-001835-0s7ok4uw	466	20	arise	arise	VB
cord-001835-0s7ok4uw	466	21	from	from	IN
cord-001835-0s7ok4uw	466	22	the	the	DT
cord-001835-0s7ok4uw	466	23	polymer	polymer	NN
cord-001835-0s7ok4uw	466	24	's	's	POS
cord-001835-0s7ok4uw	466	25	transition	transition	NN
cord-001835-0s7ok4uw	466	26	from	from	IN
cord-001835-0s7ok4uw	466	27	the	the	DT
cord-001835-0s7ok4uw	466	28	dilute	dilute	NN
cord-001835-0s7ok4uw	466	29	to	to	IN
cord-001835-0s7ok4uw	466	30	semi	semi	VB
cord-001835-0s7ok4uw	466	31	-	-	JJ
cord-001835-0s7ok4uw	466	32	dilute	dilute	JJ
cord-001835-0s7ok4uw	466	33	regime	regime	NN
cord-001835-0s7ok4uw	466	34	.	.	.
cord-001835-0s7ok4uw	467	1	The	the	DT
cord-001835-0s7ok4uw	467	2	data	datum	NNS
cord-001835-0s7ok4uw	467	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	467	4	that	that	IN
cord-001835-0s7ok4uw	467	5	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	467	6	polymers	polymer	NNS
cord-001835-0s7ok4uw	467	7	are	be	VBP
cord-001835-0s7ok4uw	467	8	not	not	RB
cord-001835-0s7ok4uw	467	9	a	a	DT
cord-001835-0s7ok4uw	467	10	valid	valid	JJ
cord-001835-0s7ok4uw	467	11	representation	representation	NN
cord-001835-0s7ok4uw	467	12	of	of	IN
cord-001835-0s7ok4uw	467	13	the	the	DT
cord-001835-0s7ok4uw	467	14	cellular	cellular	JJ
cord-001835-0s7ok4uw	467	15	interior	interior	NN
cord-001835-0s7ok4uw	467	16	.	.	.
cord-001835-0s7ok4uw	468	1	Biotechnology	Biotechnology	NNP
cord-001835-0s7ok4uw	468	2	Department	Department	NNP
cord-001835-0s7ok4uw	468	3	,	,	,
cord-001835-0s7ok4uw	468	4	University	University	NNP
cord-001835-0s7ok4uw	468	5	of	of	IN
cord-001835-0s7ok4uw	468	6	Verona	Verona	NNP
cord-001835-0s7ok4uw	468	7	Calcium	Calcium	NNP
cord-001835-0s7ok4uw	468	8	(	(	-LRB-
cord-001835-0s7ok4uw	468	9	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	468	10	)	)	-RRB-
cord-001835-0s7ok4uw	468	11	is	be	VBZ
cord-001835-0s7ok4uw	468	12	one	one	CD
cord-001835-0s7ok4uw	468	13	of	of	IN
cord-001835-0s7ok4uw	468	14	the	the	DT
cord-001835-0s7ok4uw	468	15	most	most	RBS
cord-001835-0s7ok4uw	468	16	important	important	JJ
cord-001835-0s7ok4uw	468	17	second	second	JJ
cord-001835-0s7ok4uw	468	18	messengers	messenger	NNS
cord-001835-0s7ok4uw	468	19	in	in	IN
cord-001835-0s7ok4uw	468	20	eukaryotes	eukaryote	NNS
cord-001835-0s7ok4uw	468	21	.	.	.
cord-001835-0s7ok4uw	469	1	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	470	1	binding	bind	VBG
cord-001835-0s7ok4uw	470	2	proteins	protein	NNS
cord-001835-0s7ok4uw	470	3	can	can	MD
cord-001835-0s7ok4uw	470	4	be	be	VB
cord-001835-0s7ok4uw	470	5	subdivided	subdivide	VBN
cord-001835-0s7ok4uw	470	6	into	into	IN
cord-001835-0s7ok4uw	470	7	two	two	CD
cord-001835-0s7ok4uw	470	8	categories	category	NNS
cord-001835-0s7ok4uw	470	9	:	:	:
cord-001835-0s7ok4uw	470	10	"	"	``
cord-001835-0s7ok4uw	470	11	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	471	1	buffers	buffer	NNS
cord-001835-0s7ok4uw	471	2	"	"	''
cord-001835-0s7ok4uw	471	3	that	that	WDT
cord-001835-0s7ok4uw	471	4	modulate	modulate	VBP
cord-001835-0s7ok4uw	471	5	Ca21	Ca21	.
cord-001835-0s7ok4uw	472	1	ion	ion	NN
cord-001835-0s7ok4uw	472	2	concentrations	concentration	NNS
cord-001835-0s7ok4uw	472	3	in	in	IN
cord-001835-0s7ok4uw	472	4	cells	cell	NNS
cord-001835-0s7ok4uw	472	5	,	,	,
cord-001835-0s7ok4uw	472	6	and	and	CC
cord-001835-0s7ok4uw	472	7	"	"	``
cord-001835-0s7ok4uw	472	8	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	472	9	sensors	sensor	NNS
cord-001835-0s7ok4uw	472	10	"	"	''
cord-001835-0s7ok4uw	472	11	that	that	WDT
cord-001835-0s7ok4uw	472	12	decode	decode	VBP
cord-001835-0s7ok4uw	473	1	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	474	1	signals	signal	NNS
cord-001835-0s7ok4uw	474	2	in	in	IN
cord-001835-0s7ok4uw	474	3	a	a	DT
cord-001835-0s7ok4uw	474	4	wide	wide	JJ
cord-001835-0s7ok4uw	474	5	array	array	NN
cord-001835-0s7ok4uw	474	6	of	of	IN
cord-001835-0s7ok4uw	474	7	physiological	physiological	JJ
cord-001835-0s7ok4uw	474	8	processes	process	NNS
cord-001835-0s7ok4uw	474	9	in	in	IN
cord-001835-0s7ok4uw	474	10	response	response	NN
cord-001835-0s7ok4uw	474	11	to	to	IN
cord-001835-0s7ok4uw	474	12	external	external	JJ
cord-001835-0s7ok4uw	474	13	stimuli	stimulus	NNS
cord-001835-0s7ok4uw	474	14	.	.	.
cord-001835-0s7ok4uw	475	1	Calmodulin	Calmodulin	NNP
cord-001835-0s7ok4uw	475	2	(	(	-LRB-
cord-001835-0s7ok4uw	475	3	CaM	CaM	NNP
cord-001835-0s7ok4uw	475	4	)	)	-RRB-
cord-001835-0s7ok4uw	475	5	is	be	VBZ
cord-001835-0s7ok4uw	475	6	the	the	DT
cord-001835-0s7ok4uw	475	7	prototypical	prototypical	JJ
cord-001835-0s7ok4uw	475	8	example	example	NN
cord-001835-0s7ok4uw	475	9	of	of	IN
cord-001835-0s7ok4uw	475	10	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	476	1	sensor	sensor	NN
cord-001835-0s7ok4uw	476	2	proteins	protein	NNS
cord-001835-0s7ok4uw	476	3	in	in	IN
cord-001835-0s7ok4uw	476	4	both	both	DT
cord-001835-0s7ok4uw	476	5	animals	animal	NNS
cord-001835-0s7ok4uw	476	6	and	and	CC
cord-001835-0s7ok4uw	476	7	plants	plant	NNS
cord-001835-0s7ok4uw	476	8	.	.	.
cord-001835-0s7ok4uw	477	1	In	in	IN
cord-001835-0s7ok4uw	477	2	addition	addition	NN
cord-001835-0s7ok4uw	477	3	to	to	IN
cord-001835-0s7ok4uw	477	4	conserved	conserve	VBN
cord-001835-0s7ok4uw	477	5	CaM	cam	NN
cord-001835-0s7ok4uw	477	6	,	,	,
cord-001835-0s7ok4uw	477	7	plants	plant	NNS
cord-001835-0s7ok4uw	477	8	possess	possess	VBP
cord-001835-0s7ok4uw	477	9	a	a	DT
cord-001835-0s7ok4uw	477	10	unique	unique	JJ
cord-001835-0s7ok4uw	477	11	family	family	NN
cord-001835-0s7ok4uw	477	12	of	of	IN
cord-001835-0s7ok4uw	477	13	50	50	CD
cord-001835-0s7ok4uw	477	14	CaM	cam	NN
cord-001835-0s7ok4uw	477	15	-	-	HYPH
cord-001835-0s7ok4uw	477	16	like	like	JJ
cord-001835-0s7ok4uw	477	17	proteins	protein	NNS
cord-001835-0s7ok4uw	477	18	(	(	-LRB-
cord-001835-0s7ok4uw	477	19	CMLs	CMLs	NNP
cord-001835-0s7ok4uw	477	20	)	)	-RRB-
cord-001835-0s7ok4uw	477	21	.	.	.
cord-001835-0s7ok4uw	478	1	Many	many	JJ
cord-001835-0s7ok4uw	478	2	of	of	IN
cord-001835-0s7ok4uw	478	3	these	these	DT
cord-001835-0s7ok4uw	478	4	CMLs	cml	NNS
cord-001835-0s7ok4uw	478	5	still	still	RB
cord-001835-0s7ok4uw	478	6	remain	remain	VBP
cord-001835-0s7ok4uw	478	7	uncharacterized	uncharacterized	JJ
cord-001835-0s7ok4uw	478	8	and	and	CC
cord-001835-0s7ok4uw	478	9	the	the	DT
cord-001835-0s7ok4uw	478	10	investigation	investigation	NN
cord-001835-0s7ok4uw	478	11	of	of	IN
cord-001835-0s7ok4uw	478	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	478	13	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	478	14	and	and	CC
cord-001835-0s7ok4uw	478	15	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	478	16	properties	property	NNS
cord-001835-0s7ok4uw	478	17	will	will	MD
cord-001835-0s7ok4uw	478	18	provide	provide	VB
cord-001835-0s7ok4uw	478	19	insight	insight	NN
cord-001835-0s7ok4uw	478	20	into	into	IN
cord-001835-0s7ok4uw	478	21	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	479	1	signalling	signal	VBG
cord-001835-0s7ok4uw	479	2	in	in	IN
cord-001835-0s7ok4uw	479	3	plants	plant	NNS
cord-001835-0s7ok4uw	479	4	.	.	.
cord-001835-0s7ok4uw	480	1	Herein	herein	RB
cord-001835-0s7ok4uw	480	2	,	,	,
cord-001835-0s7ok4uw	480	3	a	a	DT
cord-001835-0s7ok4uw	480	4	detailed	detailed	JJ
cord-001835-0s7ok4uw	480	5	characterization	characterization	NN
cord-001835-0s7ok4uw	480	6	of	of	IN
cord-001835-0s7ok4uw	480	7	Arabidopsis	Arabidopsis	NNP
cord-001835-0s7ok4uw	480	8	thaliana	thaliana	NN
cord-001835-0s7ok4uw	480	9	CML14	CML14	NNP
cord-001835-0s7ok4uw	480	10	is	be	VBZ
cord-001835-0s7ok4uw	480	11	reported	report	VBN
cord-001835-0s7ok4uw	480	12	.	.	.
cord-001835-0s7ok4uw	481	1	CML14	CML14	NNP
cord-001835-0s7ok4uw	481	2	is	be	VBZ
cord-001835-0s7ok4uw	481	3	a	a	DT
cord-001835-0s7ok4uw	481	4	protein	protein	NN
cord-001835-0s7ok4uw	481	5	of	of	IN
cord-001835-0s7ok4uw	481	6	148	148	CD
cord-001835-0s7ok4uw	481	7	amino	amino	JJ
cord-001835-0s7ok4uw	481	8	acids	acid	NNS
cord-001835-0s7ok4uw	481	9	with	with	IN
cord-001835-0s7ok4uw	481	10	a	a	DT
cord-001835-0s7ok4uw	481	11	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	481	12	molecular	molecular	JJ
cord-001835-0s7ok4uw	481	13	weight	weight	NN
cord-001835-0s7ok4uw	481	14	of	of	IN
cord-001835-0s7ok4uw	481	15	16,579	16,579	CD
cord-001835-0s7ok4uw	481	16	Da	Da	NNS
cord-001835-0s7ok4uw	481	17	and	and	CC
cord-001835-0s7ok4uw	481	18	50	50	CD
cord-001835-0s7ok4uw	481	19	%	%	NN
cord-001835-0s7ok4uw	481	20	amino	amino	NN
cord-001835-0s7ok4uw	481	21	acid	acid	NN
cord-001835-0s7ok4uw	481	22	sequence	sequence	NN
cord-001835-0s7ok4uw	481	23	identity	identity	NN
cord-001835-0s7ok4uw	481	24	with	with	IN
cord-001835-0s7ok4uw	481	25	AtCaM2	AtCaM2	NNP
cord-001835-0s7ok4uw	481	26	.	.	.
cord-001835-0s7ok4uw	482	1	CML14	CML14	NNP
cord-001835-0s7ok4uw	482	2	is	be	VBZ
cord-001835-0s7ok4uw	482	3	predicted	predict	VBN
cord-001835-0s7ok4uw	482	4	to	to	TO
cord-001835-0s7ok4uw	482	5	have	have	VB
cord-001835-0s7ok4uw	482	6	one	one	CD
cord-001835-0s7ok4uw	482	7	functional	functional	JJ
cord-001835-0s7ok4uw	482	8	Ca21	ca21	NN
cord-001835-0s7ok4uw	483	1	binding	bind	VBG
cord-001835-0s7ok4uw	483	2	site	site	NN
cord-001835-0s7ok4uw	483	3	despite	despite	IN
cord-001835-0s7ok4uw	483	4	the	the	DT
cord-001835-0s7ok4uw	483	5	presence	presence	NN
cord-001835-0s7ok4uw	483	6	of	of	IN
cord-001835-0s7ok4uw	483	7	three	three	CD
cord-001835-0s7ok4uw	483	8	EF	EF	NNP
cord-001835-0s7ok4uw	483	9	-	-	HYPH
cord-001835-0s7ok4uw	483	10	hand	hand	NN
cord-001835-0s7ok4uw	483	11	motifs	motif	NNS
cord-001835-0s7ok4uw	483	12	(	(	-LRB-
cord-001835-0s7ok4uw	483	13	Prosite	Prosite	NNP
cord-001835-0s7ok4uw	483	14	)	)	-RRB-
cord-001835-0s7ok4uw	483	15	.	.	.
cord-001835-0s7ok4uw	484	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	484	2	overexpressed	overexpresse	VBD
cord-001835-0s7ok4uw	484	3	CML14	cml14	RB
cord-001835-0s7ok4uw	484	4	in	in	IN
cord-001835-0s7ok4uw	484	5	E.	E.	NNP
cord-001835-0s7ok4uw	484	6	coli	coli	NNS
cord-001835-0s7ok4uw	484	7	and	and	CC
cord-001835-0s7ok4uw	484	8	analyzed	analyze	VBD
cord-001835-0s7ok4uw	484	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	484	10	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	484	11	and	and	CC
cord-001835-0s7ok4uw	484	12	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	484	13	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	484	14	,	,	,
cord-001835-0s7ok4uw	484	15	i.e.	i.e.	FW
cord-001835-0s7ok4uw	484	16	calcium	calcium	NN
cord-001835-0s7ok4uw	484	17	affinity	affinity	NN
cord-001835-0s7ok4uw	484	18	and	and	CC
cord-001835-0s7ok4uw	484	19	stoichiometry	stoichiometry	NN
cord-001835-0s7ok4uw	484	20	and	and	CC
cord-001835-0s7ok4uw	484	21	eventual	eventual	JJ
cord-001835-0s7ok4uw	484	22	changes	change	NNS
cord-001835-0s7ok4uw	484	23	in	in	IN
cord-001835-0s7ok4uw	484	24	conformation	conformation	NN
cord-001835-0s7ok4uw	484	25	,	,	,
cord-001835-0s7ok4uw	484	26	thermal	thermal	JJ
cord-001835-0s7ok4uw	484	27	stability	stability	NN
cord-001835-0s7ok4uw	484	28	and	and	CC
cord-001835-0s7ok4uw	484	29	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	484	30	susceptibility	susceptibility	NN
cord-001835-0s7ok4uw	484	31	upon	upon	IN
cord-001835-0s7ok4uw	484	32	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	484	33	binding	bind	VBG
cord-001835-0s7ok4uw	484	34	.	.	.
cord-001835-0s7ok4uw	485	1	Isothermal	Isothermal	NNP
cord-001835-0s7ok4uw	485	2	titration	titration	NN
cord-001835-0s7ok4uw	485	3	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	485	4	(	(	-LRB-
cord-001835-0s7ok4uw	485	5	ITC	ITC	NNP
cord-001835-0s7ok4uw	485	6	)	)	-RRB-
cord-001835-0s7ok4uw	485	7	and	and	CC
cord-001835-0s7ok4uw	485	8	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	485	9	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	485	10	resonance	resonance	NN
cord-001835-0s7ok4uw	485	11	(	(	-LRB-
cord-001835-0s7ok4uw	485	12	NMR	NMR	NNP
cord-001835-0s7ok4uw	485	13	)	)	-RRB-
cord-001835-0s7ok4uw	485	14	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	485	15	identified	identify	VBD
cord-001835-0s7ok4uw	485	16	one	one	CD
cord-001835-0s7ok4uw	485	17	Ca21	ca21	NN
cord-001835-0s7ok4uw	486	1	binding	bind	VBG
cord-001835-0s7ok4uw	486	2	site	site	NN
cord-001835-0s7ok4uw	486	3	in	in	IN
cord-001835-0s7ok4uw	486	4	CML14	CML14	NNP
cord-001835-0s7ok4uw	486	5	and	and	CC
cord-001835-0s7ok4uw	486	6	showed	show	VBD
cord-001835-0s7ok4uw	486	7	that	that	IN
cord-001835-0s7ok4uw	486	8	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	487	1	and	and	CC
cord-001835-0s7ok4uw	487	2	Mg21	Mg21	NNPS
cord-001835-0s7ok4uw	487	3	compete	compete	VB
cord-001835-0s7ok4uw	487	4	for	for	IN
cord-001835-0s7ok4uw	487	5	the	the	DT
cord-001835-0s7ok4uw	487	6	same	same	JJ
cord-001835-0s7ok4uw	487	7	binding	binding	NN
cord-001835-0s7ok4uw	487	8	site	site	NN
cord-001835-0s7ok4uw	487	9	.	.	.
cord-001835-0s7ok4uw	488	1	The	the	DT
cord-001835-0s7ok4uw	488	2	Kd	Kd	NNP
cord-001835-0s7ok4uw	488	3	values	value	NNS
cord-001835-0s7ok4uw	488	4	determined	determine	VBN
cord-001835-0s7ok4uw	488	5	by	by	IN
cord-001835-0s7ok4uw	488	6	ITC	ITC	NNP
cord-001835-0s7ok4uw	488	7	established	establish	VBD
cord-001835-0s7ok4uw	488	8	that	that	IN
cord-001835-0s7ok4uw	488	9	CML14	CML14	NNP
cord-001835-0s7ok4uw	488	10	has	have	VBZ
cord-001835-0s7ok4uw	488	11	higher	high	JJR
cord-001835-0s7ok4uw	488	12	affinity	affinity	NN
cord-001835-0s7ok4uw	488	13	for	for	IN
cord-001835-0s7ok4uw	488	14	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	488	15	than	than	IN
cord-001835-0s7ok4uw	488	16	for	for	IN
cord-001835-0s7ok4uw	488	17	Mg21	Mg21	NNS
cord-001835-0s7ok4uw	488	18	.	.	.
cord-001835-0s7ok4uw	489	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	489	2	data	datum	NNS
cord-001835-0s7ok4uw	489	3	were	be	VBD
cord-001835-0s7ok4uw	489	4	consistent	consistent	JJ
cord-001835-0s7ok4uw	489	5	with	with	IN
cord-001835-0s7ok4uw	489	6	the	the	DT
cord-001835-0s7ok4uw	489	7	sequence	sequence	NN
cord-001835-0s7ok4uw	489	8	based	base	VBN
cord-001835-0s7ok4uw	489	9	prediction	prediction	NN
cord-001835-0s7ok4uw	489	10	of	of	IN
cord-001835-0s7ok4uw	489	11	one	one	CD
cord-001835-0s7ok4uw	489	12	functional	functional	JJ
cord-001835-0s7ok4uw	489	13	calcium	calcium	NN
cord-001835-0s7ok4uw	489	14	binding	bind	VBG
cord-001835-0s7ok4uw	489	15	site	site	NN
cord-001835-0s7ok4uw	489	16	.	.	.
cord-001835-0s7ok4uw	490	1	Differential	differential	JJ
cord-001835-0s7ok4uw	490	2	scanning	scanning	NN
cord-001835-0s7ok4uw	490	3	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	490	4	(	(	-LRB-
cord-001835-0s7ok4uw	490	5	DSC	DSC	NNP
cord-001835-0s7ok4uw	490	6	)	)	-RRB-
cord-001835-0s7ok4uw	490	7	showed	show	VBD
cord-001835-0s7ok4uw	490	8	that	that	IN
cord-001835-0s7ok4uw	490	9	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	491	1	and	and	CC
cord-001835-0s7ok4uw	491	2	Mg21	Mg21	NNPS
cord-001835-0s7ok4uw	491	3	have	have	VBP
cord-001835-0s7ok4uw	491	4	the	the	DT
cord-001835-0s7ok4uw	491	5	same	same	JJ
cord-001835-0s7ok4uw	491	6	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	491	7	effects	effect	NNS
cord-001835-0s7ok4uw	491	8	on	on	IN
cord-001835-0s7ok4uw	491	9	protein	protein	NN
cord-001835-0s7ok4uw	491	10	folding	folding	NN
cord-001835-0s7ok4uw	491	11	.	.	.
cord-001835-0s7ok4uw	492	1	Apo	Apo	NNP
cord-001835-0s7ok4uw	492	2	-	-	HYPH
cord-001835-0s7ok4uw	492	3	CML14	CML14	NNP
cord-001835-0s7ok4uw	492	4	undergoes	undergo	VBZ
cord-001835-0s7ok4uw	492	5	two	two	CD
cord-001835-0s7ok4uw	492	6	thermal	thermal	JJ
cord-001835-0s7ok4uw	492	7	unfolding	unfold	VBG
cord-001835-0s7ok4uw	492	8	transitions	transition	NNS
cord-001835-0s7ok4uw	492	9	,	,	,
cord-001835-0s7ok4uw	492	10	but	but	CC
cord-001835-0s7ok4uw	492	11	in	in	IN
cord-001835-0s7ok4uw	492	12	the	the	DT
cord-001835-0s7ok4uw	492	13	presence	presence	NN
cord-001835-0s7ok4uw	492	14	of	of	IN
cord-001835-0s7ok4uw	492	15	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	493	1	or	or	CC
cord-001835-0s7ok4uw	493	2	Mg21	Mg21	NNPS
cord-001835-0s7ok4uw	493	3	only	only	RB
cord-001835-0s7ok4uw	493	4	one	one	CD
cord-001835-0s7ok4uw	493	5	unfolding	unfold	VBG
cord-001835-0s7ok4uw	493	6	event	event	NN
cord-001835-0s7ok4uw	493	7	at	at	IN
cord-001835-0s7ok4uw	493	8	an	an	DT
cord-001835-0s7ok4uw	493	9	intermediate	intermediate	JJ
cord-001835-0s7ok4uw	493	10	temperature	temperature	NN
cord-001835-0s7ok4uw	493	11	occurs	occur	VBZ
cord-001835-0s7ok4uw	493	12	.	.	.
cord-001835-0s7ok4uw	494	1	Limited	limited	JJ
cord-001835-0s7ok4uw	494	2	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	494	3	experiments	experiment	NNS
cord-001835-0s7ok4uw	494	4	showed	show	VBD
cord-001835-0s7ok4uw	494	5	that	that	IN
cord-001835-0s7ok4uw	494	6	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	494	7	binding	binding	NN
cord-001835-0s7ok4uw	494	8	affords	afford	VBZ
cord-001835-0s7ok4uw	494	9	protection	protection	NN
cord-001835-0s7ok4uw	494	10	against	against	IN
cord-001835-0s7ok4uw	494	11	CML14	cml14	JJ
cord-001835-0s7ok4uw	494	12	digestion	digestion	NN
cord-001835-0s7ok4uw	494	13	by	by	IN
cord-001835-0s7ok4uw	494	14	trypsin	trypsin	NN
cord-001835-0s7ok4uw	494	15	.	.	.
cord-001835-0s7ok4uw	495	1	Surprisingly	surprisingly	RB
cord-001835-0s7ok4uw	495	2	,	,	,
cord-001835-0s7ok4uw	495	3	CML14	CML14	NNP
cord-001835-0s7ok4uw	495	4	exhibits	exhibit	VBZ
cord-001835-0s7ok4uw	495	5	very	very	RB
cord-001835-0s7ok4uw	495	6	few	few	JJ
cord-001835-0s7ok4uw	495	7	conformational	conformational	JJ
cord-001835-0s7ok4uw	495	8	changes	change	NNS
cord-001835-0s7ok4uw	495	9	upon	upon	IN
cord-001835-0s7ok4uw	495	10	calcium	calcium	NN
cord-001835-0s7ok4uw	495	11	binding	binding	NN
cord-001835-0s7ok4uw	495	12	,	,	,
cord-001835-0s7ok4uw	495	13	which	which	WDT
cord-001835-0s7ok4uw	495	14	were	be	VBD
cord-001835-0s7ok4uw	495	15	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	495	16	by	by	IN
cord-001835-0s7ok4uw	495	17	ANS	ANS	NNP
cord-001835-0s7ok4uw	495	18	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	495	19	and	and	CC
cord-001835-0s7ok4uw	495	20	Stokes	Stokes	NNP
cord-001835-0s7ok4uw	495	21	radius	radius	NN
cord-001835-0s7ok4uw	495	22	measurements	measurement	NNS
cord-001835-0s7ok4uw	495	23	in	in	IN
cord-001835-0s7ok4uw	495	24	the	the	DT
cord-001835-0s7ok4uw	495	25	apo	apo	NNP
cord-001835-0s7ok4uw	495	26	-	-	HYPH
cord-001835-0s7ok4uw	495	27	and	and	CC
cord-001835-0s7ok4uw	495	28	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	495	29	bound	bind	VBN
cord-001835-0s7ok4uw	495	30	-	-	HYPH
cord-001835-0s7ok4uw	495	31	forms	form	NNS
cord-001835-0s7ok4uw	495	32	.	.	.
cord-001835-0s7ok4uw	496	1	These	these	DT
cord-001835-0s7ok4uw	496	2	results	result	NNS
cord-001835-0s7ok4uw	496	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	496	4	that	that	IN
cord-001835-0s7ok4uw	496	5	CML14	CML14	NNP
cord-001835-0s7ok4uw	496	6	does	do	VBZ
cord-001835-0s7ok4uw	496	7	not	not	RB
cord-001835-0s7ok4uw	496	8	show	show	VB
cord-001835-0s7ok4uw	496	9	the	the	DT
cord-001835-0s7ok4uw	496	10	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	496	11	of	of	IN
cord-001835-0s7ok4uw	496	12	a	a	DT
cord-001835-0s7ok4uw	496	13	classical	classical	JJ
cord-001835-0s7ok4uw	496	14	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	496	15	sensor	sensor	NN
cord-001835-0s7ok4uw	496	16	protein	protein	NN
cord-001835-0s7ok4uw	496	17	.	.	.
cord-001835-0s7ok4uw	497	1	To	to	TO
cord-001835-0s7ok4uw	497	2	better	well	RBR
cord-001835-0s7ok4uw	497	3	understand	understand	VB
cord-001835-0s7ok4uw	497	4	the	the	DT
cord-001835-0s7ok4uw	497	5	physiological	physiological	JJ
cord-001835-0s7ok4uw	497	6	role	role	NN
cord-001835-0s7ok4uw	497	7	of	of	IN
cord-001835-0s7ok4uw	497	8	CML14	CML14	NNP
cord-001835-0s7ok4uw	497	9	in	in	IN
cord-001835-0s7ok4uw	497	10	plants	plant	NNS
cord-001835-0s7ok4uw	497	11	,	,	,
cord-001835-0s7ok4uw	497	12	in	in	IN
cord-001835-0s7ok4uw	497	13	vivo	vivo	NN
cord-001835-0s7ok4uw	497	14	analysis	analysis	NN
cord-001835-0s7ok4uw	497	15	will	will	MD
cord-001835-0s7ok4uw	497	16	be	be	VB
cord-001835-0s7ok4uw	497	17	performed	perform	VBN
cord-001835-0s7ok4uw	497	18	.	.	.
cord-001835-0s7ok4uw	498	1	PB-068	PB-068	NNP
cord-001835-0s7ok4uw	499	1	FBP17	FBP17	NNP
cord-001835-0s7ok4uw	499	2	controls	control	VBZ
cord-001835-0s7ok4uw	499	3	the	the	DT
cord-001835-0s7ok4uw	499	4	hepatocyte	hepatocyte	NN
cord-001835-0s7ok4uw	499	5	morphology	morphology	NN
cord-001835-0s7ok4uw	499	6	through	through	IN
cord-001835-0s7ok4uw	499	7	Rho	Rho	NNP
cord-001835-0s7ok4uw	499	8	signaling	signal	VBG
cord-001835-0s7ok4uw	499	9	Jun	Jun	NNP
cord-001835-0s7ok4uw	499	10	Zhang	Zhang	NNP
cord-001835-0s7ok4uw	499	11	1	1	CD
cord-001835-0s7ok4uw	499	12	,	,	,
cord-001835-0s7ok4uw	499	13	Mingming	Mingming	NNP
cord-001835-0s7ok4uw	499	14	Ling	Ling	NNP
cord-001835-0s7ok4uw	499	15	1	1	CD
cord-001835-0s7ok4uw	499	16	,	,	,
cord-001835-0s7ok4uw	499	17	Qianying	Qianying	NNP
cord-001835-0s7ok4uw	499	18	Zhang	Zhang	NNP
cord-001835-0s7ok4uw	499	19	1	1	CD
cord-001835-0s7ok4uw	499	20	,	,	,
cord-001835-0s7ok4uw	499	21	Yunhong	Yunhong	NNP
cord-001835-0s7ok4uw	499	22	Wang	Wang	NNP
cord-001835-0s7ok4uw	499	23	1	1	CD
cord-001835-0s7ok4uw	499	24	,	,	,
cord-001835-0s7ok4uw	499	25	Deqiang	Deqiang	NNP
cord-001835-0s7ok4uw	499	26	Wang	Wang	NNP
cord-001835-0s7ok4uw	499	27	2	2	CD
cord-001835-0s7ok4uw	499	28	1	1	CD
cord-001835-0s7ok4uw	500	1	The	the	DT
cord-001835-0s7ok4uw	500	2	Department	Department	NNP
cord-001835-0s7ok4uw	500	3	of	of	IN
cord-001835-0s7ok4uw	500	4	Cell	Cell	NNP
cord-001835-0s7ok4uw	500	5	Biology	Biology	NNP
cord-001835-0s7ok4uw	500	6	and	and	CC
cord-001835-0s7ok4uw	500	7	Genetics	Genetics	NNP
cord-001835-0s7ok4uw	500	8	,	,	,
cord-001835-0s7ok4uw	500	9	2	2	CD
cord-001835-0s7ok4uw	500	10	 	 	_SP
cord-001835-0s7ok4uw	500	11	The	the	DT
cord-001835-0s7ok4uw	500	12	formin	formin	NN
cord-001835-0s7ok4uw	500	13	-	-	HYPH
cord-001835-0s7ok4uw	500	14	binding	bind	VBG
cord-001835-0s7ok4uw	500	15	protein	protein	NN
cord-001835-0s7ok4uw	500	16	17	17	CD
cord-001835-0s7ok4uw	500	17	(	(	-LRB-
cord-001835-0s7ok4uw	500	18	FBP17	fbp17	NN
cord-001835-0s7ok4uw	500	19	)	)	-RRB-
cord-001835-0s7ok4uw	500	20	widely	widely	RB
cord-001835-0s7ok4uw	500	21	expressed	express	VBN
cord-001835-0s7ok4uw	500	22	in	in	IN
cord-001835-0s7ok4uw	500	23	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	500	24	cells	cell	NNS
cord-001835-0s7ok4uw	500	25	was	be	VBD
cord-001835-0s7ok4uw	500	26	previously	previously	RB
cord-001835-0s7ok4uw	500	27	identified	identify	VBN
cord-001835-0s7ok4uw	500	28	to	to	TO
cord-001835-0s7ok4uw	500	29	play	play	VB
cord-001835-0s7ok4uw	500	30	a	a	DT
cord-001835-0s7ok4uw	500	31	role	role	NN
cord-001835-0s7ok4uw	500	32	in	in	IN
cord-001835-0s7ok4uw	500	33	morphological	morphological	JJ
cord-001835-0s7ok4uw	500	34	maintenance	maintenance	NN
cord-001835-0s7ok4uw	500	35	in	in	IN
cord-001835-0s7ok4uw	500	36	hepatocyte	hepatocyte	NN
cord-001835-0s7ok4uw	500	37	,	,	,
cord-001835-0s7ok4uw	500	38	but	but	CC
cord-001835-0s7ok4uw	500	39	the	the	DT
cord-001835-0s7ok4uw	500	40	molecular	molecular	JJ
cord-001835-0s7ok4uw	500	41	mechanism	mechanism	NN
cord-001835-0s7ok4uw	500	42	keeps	keep	VBZ
cord-001835-0s7ok4uw	500	43	still	still	RB
cord-001835-0s7ok4uw	500	44	unclear	unclear	JJ
cord-001835-0s7ok4uw	500	45	so	so	RB
cord-001835-0s7ok4uw	500	46	far	far	RB
cord-001835-0s7ok4uw	500	47	.	.	.
cord-001835-0s7ok4uw	501	1	In	in	IN
cord-001835-0s7ok4uw	501	2	the	the	DT
cord-001835-0s7ok4uw	501	3	present	present	JJ
cord-001835-0s7ok4uw	501	4	investigation	investigation	NN
cord-001835-0s7ok4uw	501	5	,	,	,
cord-001835-0s7ok4uw	501	6	it	-PRON-	PRP
cord-001835-0s7ok4uw	501	7	was	be	VBD
cord-001835-0s7ok4uw	501	8	found	find	VBN
cord-001835-0s7ok4uw	501	9	that	that	IN
cord-001835-0s7ok4uw	501	10	Rho	Rho	NNP
cord-001835-0s7ok4uw	501	11	family	family	NN
cord-001835-0s7ok4uw	501	12	proteins	protein	NNS
cord-001835-0s7ok4uw	502	1	CDC42	CDC42	NNP
cord-001835-0s7ok4uw	502	2	/	/	SYM
cord-001835-0s7ok4uw	502	3	RAC1	RAC1	NNP
cord-001835-0s7ok4uw	502	4	signaling	signaling	NN
cord-001835-0s7ok4uw	502	5	was	be	VBD
cord-001835-0s7ok4uw	502	6	involved	involve	VBN
cord-001835-0s7ok4uw	502	7	in	in	IN
cord-001835-0s7ok4uw	502	8	the	the	DT
cord-001835-0s7ok4uw	502	9	morphological	morphological	JJ
cord-001835-0s7ok4uw	502	10	regulation	regulation	NN
cord-001835-0s7ok4uw	502	11	controlled	control	VBN
cord-001835-0s7ok4uw	502	12	by	by	IN
cord-001835-0s7ok4uw	502	13	FBP17	FBP17	NNP
cord-001835-0s7ok4uw	502	14	.	.	.
cord-001835-0s7ok4uw	503	1	Knockdown	knockdown	NN
cord-001835-0s7ok4uw	503	2	of	of	IN
cord-001835-0s7ok4uw	503	3	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	503	4	FBP17	fbp17	CD
cord-001835-0s7ok4uw	503	5	expression	expression	NN
cord-001835-0s7ok4uw	503	6	with	with	IN
cord-001835-0s7ok4uw	503	7	RNAi	RNAi	NNP
cord-001835-0s7ok4uw	503	8	technique	technique	NN
cord-001835-0s7ok4uw	503	9	or	or	CC
cord-001835-0s7ok4uw	503	10	dominant	dominant	JJ
cord-001835-0s7ok4uw	503	11	negative	negative	JJ
cord-001835-0s7ok4uw	503	12	mutant	mutant	NN
cord-001835-0s7ok4uw	503	13	of	of	IN
cord-001835-0s7ok4uw	503	14	FBP17	FBP17	NNP
cord-001835-0s7ok4uw	503	15	could	could	MD
cord-001835-0s7ok4uw	503	16	trigger	trigger	VB
cord-001835-0s7ok4uw	503	17	the	the	DT
cord-001835-0s7ok4uw	503	18	cell	cell	NN
cord-001835-0s7ok4uw	503	19	morphological	morphological	JJ
cord-001835-0s7ok4uw	503	20	remodeling	remodeling	NN
cord-001835-0s7ok4uw	503	21	from	from	IN
cord-001835-0s7ok4uw	503	22	the	the	DT
cord-001835-0s7ok4uw	503	23	epithelioid	epithelioid	NN
cord-001835-0s7ok4uw	503	24	to	to	IN
cord-001835-0s7ok4uw	503	25	fibroid	fibroid	NN
cord-001835-0s7ok4uw	503	26	following	follow	VBG
cord-001835-0s7ok4uw	503	27	the	the	DT
cord-001835-0s7ok4uw	503	28	significant	significant	JJ
cord-001835-0s7ok4uw	503	29	down	down	NN
cord-001835-0s7ok4uw	503	30	-	-	HYPH
cord-001835-0s7ok4uw	503	31	regulation	regulation	NN
cord-001835-0s7ok4uw	503	32	of	of	IN
cord-001835-0s7ok4uw	503	33	CDC42/	CDC42/	NNP
cord-001835-0s7ok4uw	503	34	RAC1	RAC1	NNP
cord-001835-0s7ok4uw	503	35	activities	activity	NNS
cord-001835-0s7ok4uw	503	36	and	and	CC
cord-001835-0s7ok4uw	503	37	dephosphorylation	dephosphorylation	NN
cord-001835-0s7ok4uw	503	38	of	of	IN
cord-001835-0s7ok4uw	503	39	paxillin	paxillin	NNP
cord-001835-0s7ok4uw	503	40	.	.	.
cord-001835-0s7ok4uw	504	1	While	while	IN
cord-001835-0s7ok4uw	504	2	the	the	DT
cord-001835-0s7ok4uw	504	3	Rho	Rho	NNP
cord-001835-0s7ok4uw	504	4	protein	protein	NN
cord-001835-0s7ok4uw	504	5	specific	specific	JJ
cord-001835-0s7ok4uw	504	6	activator	activator	NN
cord-001835-0s7ok4uw	504	7	could	could	MD
cord-001835-0s7ok4uw	504	8	restore	restore	VB
cord-001835-0s7ok4uw	504	9	the	the	DT
cord-001835-0s7ok4uw	504	10	CDC42	CDC42	NNP
cord-001835-0s7ok4uw	504	11	/	/	SYM
cord-001835-0s7ok4uw	504	12	RAC1	RAC1	NNP
cord-001835-0s7ok4uw	504	13	activities	activity	NNS
cord-001835-0s7ok4uw	504	14	,	,	,
cord-001835-0s7ok4uw	504	15	and	and	CC
cord-001835-0s7ok4uw	504	16	in	in	IN
cord-001835-0s7ok4uw	504	17	turn	turn	NN
cord-001835-0s7ok4uw	504	18	abrogated	abrogate	VBD
cord-001835-0s7ok4uw	504	19	the	the	DT
cord-001835-0s7ok4uw	504	20	silence	silence	NN
cord-001835-0s7ok4uw	504	21	effect	effect	NN
cord-001835-0s7ok4uw	504	22	.	.	.
cord-001835-0s7ok4uw	505	1	Overexpression	overexpression	NN
cord-001835-0s7ok4uw	505	2	of	of	IN
cord-001835-0s7ok4uw	505	3	wild	wild	JJ
cord-001835-0s7ok4uw	505	4	type	type	NN
cord-001835-0s7ok4uw	505	5	FBP17	fbp17	PRP
cord-001835-0s7ok4uw	505	6	could	could	MD
cord-001835-0s7ok4uw	505	7	not	not	RB
cord-001835-0s7ok4uw	505	8	result	result	VB
cord-001835-0s7ok4uw	505	9	in	in	IN
cord-001835-0s7ok4uw	505	10	any	any	DT
cord-001835-0s7ok4uw	505	11	of	of	IN
cord-001835-0s7ok4uw	505	12	the	the	DT
cord-001835-0s7ok4uw	505	13	morphological	morphological	JJ
cord-001835-0s7ok4uw	505	14	transition	transition	NN
cord-001835-0s7ok4uw	505	15	.	.	.
cord-001835-0s7ok4uw	506	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	506	2	,	,	,
cord-001835-0s7ok4uw	506	3	withdrawal	withdrawal	NN
cord-001835-0s7ok4uw	506	4	of	of	IN
cord-001835-0s7ok4uw	506	5	the	the	DT
cord-001835-0s7ok4uw	506	6	silence	silence	NN
cord-001835-0s7ok4uw	506	7	could	could	MD
cord-001835-0s7ok4uw	506	8	induce	induce	VB
cord-001835-0s7ok4uw	506	9	morphological	morphological	JJ
cord-001835-0s7ok4uw	506	10	recovery	recovery	NN
cord-001835-0s7ok4uw	506	11	when	when	WRB
cord-001835-0s7ok4uw	506	12	the	the	DT
cord-001835-0s7ok4uw	506	13	FBP17	fbp17	CD
cord-001835-0s7ok4uw	506	14	expression	expression	NN
cord-001835-0s7ok4uw	506	15	,	,	,
cord-001835-0s7ok4uw	506	16	CDC42	CDC42	NNP
cord-001835-0s7ok4uw	506	17	/	/	SYM
cord-001835-0s7ok4uw	506	18	RAC1	RAC1	NNP
cord-001835-0s7ok4uw	506	19	activities	activity	NNS
cord-001835-0s7ok4uw	506	20	and	and	CC
cord-001835-0s7ok4uw	506	21	paxillin	paxillin	JJ
cord-001835-0s7ok4uw	506	22	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	506	23	were	be	VBD
cord-001835-0s7ok4uw	506	24	restored	restore	VBN
cord-001835-0s7ok4uw	506	25	to	to	IN
cord-001835-0s7ok4uw	506	26	the	the	DT
cord-001835-0s7ok4uw	506	27	normal	normal	JJ
cord-001835-0s7ok4uw	506	28	level	level	NN
cord-001835-0s7ok4uw	506	29	.	.	.
cord-001835-0s7ok4uw	507	1	The	the	DT
cord-001835-0s7ok4uw	507	2	experimental	experimental	JJ
cord-001835-0s7ok4uw	507	3	evidences	evidence	NNS
cord-001835-0s7ok4uw	507	4	strongly	strongly	RB
cord-001835-0s7ok4uw	507	5	indicated	indicate	VBD
cord-001835-0s7ok4uw	507	6	that	that	IN
cord-001835-0s7ok4uw	507	7	FBP17	FBP17	NNP
cord-001835-0s7ok4uw	507	8	was	be	VBD
cord-001835-0s7ok4uw	507	9	implicated	implicate	VBN
cord-001835-0s7ok4uw	507	10	in	in	IN
cord-001835-0s7ok4uw	507	11	morphological	morphological	JJ
cord-001835-0s7ok4uw	507	12	control	control	NN
cord-001835-0s7ok4uw	507	13	probably	probably	RB
cord-001835-0s7ok4uw	507	14	via	via	IN
cord-001835-0s7ok4uw	507	15	Rho	Rho	NNP
cord-001835-0s7ok4uw	507	16	signaling	signal	VBG
cord-001835-0s7ok4uw	507	17	pathway	pathway	NN
cord-001835-0s7ok4uw	507	18	in	in	IN
cord-001835-0s7ok4uw	507	19	hepatocyte	hepatocyte	NN
cord-001835-0s7ok4uw	507	20	.	.	.
cord-001835-0s7ok4uw	508	1	Key	key	JJ
cord-001835-0s7ok4uw	508	2	words	word	NNS
cord-001835-0s7ok4uw	508	3	:	:	:
cord-001835-0s7ok4uw	508	4	FBP17	fbp17	LS
cord-001835-0s7ok4uw	508	5	;	;	:
cord-001835-0s7ok4uw	508	6	Rho	Rho	NNP
cord-001835-0s7ok4uw	508	7	signaling	signaling	NN
cord-001835-0s7ok4uw	508	8	;	;	:
cord-001835-0s7ok4uw	508	9	paxillin	paxillin	JJ
cord-001835-0s7ok4uw	508	10	;	;	,
cord-001835-0s7ok4uw	508	11	morphological	morphological	JJ
cord-001835-0s7ok4uw	508	12	control	control	NN
cord-001835-0s7ok4uw	508	13	;	;	:
cord-001835-0s7ok4uw	508	14	hepatocyte	hepatocyte	NN
cord-001835-0s7ok4uw	509	1	This	this	DT
cord-001835-0s7ok4uw	509	2	work	work	NN
cord-001835-0s7ok4uw	509	3	was	be	VBD
cord-001835-0s7ok4uw	509	4	supported	support	VBN
cord-001835-0s7ok4uw	509	5	by	by	IN
cord-001835-0s7ok4uw	509	6	a	a	DT
cord-001835-0s7ok4uw	509	7	grant	grant	NN
cord-001835-0s7ok4uw	509	8	from	from	IN
cord-001835-0s7ok4uw	509	9	National	National	NNP
cord-001835-0s7ok4uw	509	10	Natural	Natural	NNP
cord-001835-0s7ok4uw	509	11	Science	Science	NNP
cord-001835-0s7ok4uw	509	12	Foundation	Foundation	NNP
cord-001835-0s7ok4uw	509	13	of	of	IN
cord-001835-0s7ok4uw	509	14	China	China	NNP
cord-001835-0s7ok4uw	509	15	(	(	-LRB-
cord-001835-0s7ok4uw	509	16	NSFC	NSFC	NNP
cord-001835-0s7ok4uw	509	17	,	,	,
cord-001835-0s7ok4uw	509	18	no	no	UH
cord-001835-0s7ok4uw	509	19	.	.	.
cord-001835-0s7ok4uw	510	1	Cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	510	2	c	c	NN
cord-001835-0s7ok4uw	510	3	oxidase	oxidase	NN
cord-001835-0s7ok4uw	510	4	(	(	-LRB-
cord-001835-0s7ok4uw	510	5	CcO	CcO	NNP
cord-001835-0s7ok4uw	510	6	)	)	-RRB-
cord-001835-0s7ok4uw	510	7	is	be	VBZ
cord-001835-0s7ok4uw	510	8	the	the	DT
cord-001835-0s7ok4uw	510	9	final	final	JJ
cord-001835-0s7ok4uw	510	10	enzyme	enzyme	NN
cord-001835-0s7ok4uw	510	11	in	in	IN
cord-001835-0s7ok4uw	510	12	the	the	DT
cord-001835-0s7ok4uw	510	13	respiratory	respiratory	JJ
cord-001835-0s7ok4uw	510	14	chain	chain	NN
cord-001835-0s7ok4uw	510	15	of	of	IN
cord-001835-0s7ok4uw	510	16	mitochondria	mitochondrion	NNS
cord-001835-0s7ok4uw	510	17	but	but	CC
cord-001835-0s7ok4uw	510	18	also	also	RB
cord-001835-0s7ok4uw	510	19	an	an	DT
cord-001835-0s7ok4uw	510	20	integral	integral	JJ
cord-001835-0s7ok4uw	510	21	part	part	NN
cord-001835-0s7ok4uw	510	22	of	of	IN
cord-001835-0s7ok4uw	510	23	the	the	DT
cord-001835-0s7ok4uw	510	24	metabolism	metabolism	NN
cord-001835-0s7ok4uw	510	25	of	of	IN
cord-001835-0s7ok4uw	510	26	many	many	JJ
cord-001835-0s7ok4uw	510	27	types	type	NNS
cord-001835-0s7ok4uw	510	28	of	of	IN
cord-001835-0s7ok4uw	510	29	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	510	30	.	.	.
cord-001835-0s7ok4uw	511	1	In	in	IN
cord-001835-0s7ok4uw	511	2	a	a	DT
cord-001835-0s7ok4uw	511	3	complex	complex	JJ
cord-001835-0s7ok4uw	511	4	,	,	,
cord-001835-0s7ok4uw	511	5	stepwise	stepwise	JJ
cord-001835-0s7ok4uw	511	6	redox	redox	NN
cord-001835-0s7ok4uw	511	7	-	-	HYPH
cord-001835-0s7ok4uw	511	8	reaction	reaction	NN
cord-001835-0s7ok4uw	511	9	,	,	,
cord-001835-0s7ok4uw	511	10	CcO	CcO	NNP
cord-001835-0s7ok4uw	511	11	catalyzes	catalyze	VBZ
cord-001835-0s7ok4uw	511	12	the	the	DT
cord-001835-0s7ok4uw	511	13	reduction	reduction	NN
cord-001835-0s7ok4uw	511	14	of	of	IN
cord-001835-0s7ok4uw	511	15	molecular	molecular	JJ
cord-001835-0s7ok4uw	511	16	oxygen	oxygen	NN
cord-001835-0s7ok4uw	511	17	to	to	IN
cord-001835-0s7ok4uw	511	18	water	water	NN
cord-001835-0s7ok4uw	511	19	and	and	CC
cord-001835-0s7ok4uw	511	20	utilizes	utilize	VBZ
cord-001835-0s7ok4uw	511	21	the	the	DT
cord-001835-0s7ok4uw	511	22	resulting	result	VBG
cord-001835-0s7ok4uw	511	23	free	free	JJ
cord-001835-0s7ok4uw	511	24	energy	energy	NN
cord-001835-0s7ok4uw	511	25	to	to	TO
cord-001835-0s7ok4uw	511	26	pump	pump	VB
cord-001835-0s7ok4uw	511	27	protons	proton	NNS
cord-001835-0s7ok4uw	511	28	across	across	IN
cord-001835-0s7ok4uw	511	29	the	the	DT
cord-001835-0s7ok4uw	511	30	membrane	membrane	NN
cord-001835-0s7ok4uw	511	31	thereby	thereby	RB
cord-001835-0s7ok4uw	511	32	creating	create	VBG
cord-001835-0s7ok4uw	511	33	an	an	DT
cord-001835-0s7ok4uw	511	34	electrochemical	electrochemical	JJ
cord-001835-0s7ok4uw	511	35	gradient	gradient	NN
cord-001835-0s7ok4uw	511	36	[	[	-LRB-
cord-001835-0s7ok4uw	511	37	1	1	CD
cord-001835-0s7ok4uw	511	38	,	,	,
cord-001835-0s7ok4uw	511	39	2	2	CD
cord-001835-0s7ok4uw	511	40	]	]	-RRB-
cord-001835-0s7ok4uw	511	41	.	.	.
cord-001835-0s7ok4uw	512	1	To	to	TO
cord-001835-0s7ok4uw	512	2	investigate	investigate	VB
cord-001835-0s7ok4uw	512	3	proton	proton	NN
cord-001835-0s7ok4uw	512	4	pumping	pumping	NN
cord-001835-0s7ok4uw	512	5	spectroscopically	spectroscopically	RB
cord-001835-0s7ok4uw	512	6	it	-PRON-	PRP
cord-001835-0s7ok4uw	512	7	is	be	VBZ
cord-001835-0s7ok4uw	512	8	possible	possible	JJ
cord-001835-0s7ok4uw	512	9	to	to	TO
cord-001835-0s7ok4uw	512	10	label	label	VB
cord-001835-0s7ok4uw	512	11	the	the	DT
cord-001835-0s7ok4uw	512	12	entrance	entrance	NN
cord-001835-0s7ok4uw	512	13	of	of	IN
cord-001835-0s7ok4uw	512	14	the	the	DT
cord-001835-0s7ok4uw	512	15	proton	proton	NN
cord-001835-0s7ok4uw	512	16	entrance	entrance	NN
cord-001835-0s7ok4uw	512	17	channel	channel	NN
cord-001835-0s7ok4uw	512	18	with	with	IN
cord-001835-0s7ok4uw	512	19	fluorescein	fluorescein	NNP
cord-001835-0s7ok4uw	512	20	,	,	,
cord-001835-0s7ok4uw	512	21	a	a	DT
cord-001835-0s7ok4uw	512	22	pH	ph	NN
cord-001835-0s7ok4uw	512	23	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	512	24	dye	dye	NN
cord-001835-0s7ok4uw	512	25	,	,	,
cord-001835-0s7ok4uw	512	26	which	which	WDT
cord-001835-0s7ok4uw	512	27	allows	allow	VBZ
cord-001835-0s7ok4uw	512	28	determining	determine	VBG
cord-001835-0s7ok4uw	512	29	time	time	NN
cord-001835-0s7ok4uw	512	30	resolved	resolve	VBD
cord-001835-0s7ok4uw	512	31	local	local	JJ
cord-001835-0s7ok4uw	512	32	changes	change	NNS
cord-001835-0s7ok4uw	512	33	in	in	IN
cord-001835-0s7ok4uw	512	34	proton	proton	NN
cord-001835-0s7ok4uw	512	35	concentration	concentration	NN
cord-001835-0s7ok4uw	512	36	at	at	IN
cord-001835-0s7ok4uw	512	37	the	the	DT
cord-001835-0s7ok4uw	512	38	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	512	39	CcO	cco	NN
cord-001835-0s7ok4uw	512	40	surface	surface	NN
cord-001835-0s7ok4uw	512	41	and	and	CC
cord-001835-0s7ok4uw	512	42	related	related	JJ
cord-001835-0s7ok4uw	512	43	properties	property	NNS
cord-001835-0s7ok4uw	512	44	.	.	.
cord-001835-0s7ok4uw	513	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	513	2	has	have	VBZ
cord-001835-0s7ok4uw	513	3	already	already	RB
cord-001835-0s7ok4uw	513	4	been	be	VBN
cord-001835-0s7ok4uw	513	5	shown	show	VBN
cord-001835-0s7ok4uw	513	6	that	that	IN
cord-001835-0s7ok4uw	513	7	the	the	DT
cord-001835-0s7ok4uw	513	8	redox	redox	JJ
cord-001835-0s7ok4uw	513	9	state	state	NN
cord-001835-0s7ok4uw	513	10	of	of	IN
cord-001835-0s7ok4uw	513	11	copper	copper	NN
cord-001835-0s7ok4uw	513	12	and	and	CC
cord-001835-0s7ok4uw	513	13	heme	heme	NN
cord-001835-0s7ok4uw	513	14	centers	center	NNS
cord-001835-0s7ok4uw	513	15	affects	affect	VBZ
cord-001835-0s7ok4uw	513	16	such	such	JJ
cord-001835-0s7ok4uw	513	17	properties	property	NNS
cord-001835-0s7ok4uw	513	18	at	at	IN
cord-001835-0s7ok4uw	513	19	the	the	DT
cord-001835-0s7ok4uw	513	20	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	513	21	surface	surface	NN
cord-001835-0s7ok4uw	513	22	.	.	.
cord-001835-0s7ok4uw	514	1	[	[	-LRB-
cord-001835-0s7ok4uw	514	2	3	3	CD
cord-001835-0s7ok4uw	514	3	]	]	-RRB-
cord-001835-0s7ok4uw	515	1	This	this	DT
cord-001835-0s7ok4uw	515	2	study	study	NN
cord-001835-0s7ok4uw	515	3	is	be	VBZ
cord-001835-0s7ok4uw	515	4	a	a	DT
cord-001835-0s7ok4uw	515	5	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	515	6	approach	approach	NN
cord-001835-0s7ok4uw	515	7	to	to	TO
cord-001835-0s7ok4uw	515	8	investigate	investigate	VB
cord-001835-0s7ok4uw	515	9	changes	change	NNS
cord-001835-0s7ok4uw	515	10	of	of	IN
cord-001835-0s7ok4uw	515	11	pKA	pKA	NNS
cord-001835-0s7ok4uw	515	12	values	value	NNS
cord-001835-0s7ok4uw	515	13	of	of	IN
cord-001835-0s7ok4uw	515	14	the	the	DT
cord-001835-0s7ok4uw	515	15	fluorescein	fluorescein	NNP
cord-001835-0s7ok4uw	515	16	label	label	NN
cord-001835-0s7ok4uw	515	17	at	at	IN
cord-001835-0s7ok4uw	515	18	the	the	DT
cord-001835-0s7ok4uw	515	19	entrance	entrance	NN
cord-001835-0s7ok4uw	515	20	of	of	IN
cord-001835-0s7ok4uw	515	21	the	the	DT
cord-001835-0s7ok4uw	515	22	K	K	NNP
cord-001835-0s7ok4uw	515	23	-	-	HYPH
cord-001835-0s7ok4uw	515	24	channel	channel	NN
cord-001835-0s7ok4uw	515	25	for	for	IN
cord-001835-0s7ok4uw	515	26	different	different	JJ
cord-001835-0s7ok4uw	515	27	protonation	protonation	NN
cord-001835-0s7ok4uw	515	28	pattern	pattern	NN
cord-001835-0s7ok4uw	515	29	in	in	IN
cord-001835-0s7ok4uw	515	30	both	both	CC
cord-001835-0s7ok4uw	515	31	oxidized	oxidize	VBN
cord-001835-0s7ok4uw	515	32	and	and	CC
cord-001835-0s7ok4uw	515	33	reduced	reduce	VBN
cord-001835-0s7ok4uw	515	34	CcO	CcO	NNS
cord-001835-0s7ok4uw	515	35	by	by	IN
cord-001835-0s7ok4uw	515	36	performing	perform	VBG
cord-001835-0s7ok4uw	515	37	molecular	molecular	JJ
cord-001835-0s7ok4uw	515	38	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	515	39	(	(	-LRB-
cord-001835-0s7ok4uw	515	40	MD	MD	NNP
cord-001835-0s7ok4uw	515	41	)	)	-RRB-
cord-001835-0s7ok4uw	515	42	simulations	simulation	NNS
cord-001835-0s7ok4uw	515	43	.	.	.
cord-001835-0s7ok4uw	516	1	Further	further	JJ
cord-001835-0s7ok4uw	516	2	work	work	NN
cord-001835-0s7ok4uw	516	3	is	be	VBZ
cord-001835-0s7ok4uw	516	4	based	base	VBN
cord-001835-0s7ok4uw	516	5	on	on	IN
cord-001835-0s7ok4uw	516	6	calculations	calculation	NNS
cord-001835-0s7ok4uw	516	7	of	of	IN
cord-001835-0s7ok4uw	516	8	pKA	pKA	NNS
cord-001835-0s7ok4uw	516	9	values	value	NNS
cord-001835-0s7ok4uw	516	10	of	of	IN
cord-001835-0s7ok4uw	516	11	the	the	DT
cord-001835-0s7ok4uw	516	12	fluorescein	fluorescein	NN
cord-001835-0s7ok4uw	516	13	using	use	VBG
cord-001835-0s7ok4uw	516	14	software	software	NN
cord-001835-0s7ok4uw	516	15	Karlsberg1	Karlsberg1	NNP
cord-001835-0s7ok4uw	517	1	[	[	-LRB-
cord-001835-0s7ok4uw	517	2	4	4	CD
cord-001835-0s7ok4uw	517	3	,	,	,
cord-001835-0s7ok4uw	517	4	5	5	CD
cord-001835-0s7ok4uw	517	5	]	]	-RRB-
cord-001835-0s7ok4uw	517	6	.	.	.
cord-001835-0s7ok4uw	517	7	 	 	_SP
cord-001835-0s7ok4uw	518	1	Methods	method	NNS
cord-001835-0s7ok4uw	518	2	for	for	IN
cord-001835-0s7ok4uw	518	3	genetically	genetically	RB
cord-001835-0s7ok4uw	518	4	and	and	CC
cord-001835-0s7ok4uw	518	5	synthetically	synthetically	RB
cord-001835-0s7ok4uw	518	6	manipulating	manipulate	VBG
cord-001835-0s7ok4uw	518	7	protein	protein	NN
cord-001835-0s7ok4uw	518	8	structure	structure	NN
cord-001835-0s7ok4uw	518	9	enable	enable	VBP
cord-001835-0s7ok4uw	518	10	a	a	DT
cord-001835-0s7ok4uw	518	11	greater	great	JJR
cord-001835-0s7ok4uw	518	12	flexibility	flexibility	NN
cord-001835-0s7ok4uw	518	13	in	in	IN
cord-001835-0s7ok4uw	518	14	the	the	DT
cord-001835-0s7ok4uw	518	15	study	study	NN
cord-001835-0s7ok4uw	518	16	of	of	IN
cord-001835-0s7ok4uw	518	17	protein	protein	NN
cord-001835-0s7ok4uw	518	18	function	function	NN
cord-001835-0s7ok4uw	518	19	.	.	.
cord-001835-0s7ok4uw	519	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	519	2	have	have	VBP
cord-001835-0s7ok4uw	519	3	shown	show	VBN
cord-001835-0s7ok4uw	519	4	that	that	IN
cord-001835-0s7ok4uw	519	5	using	use	VBG
cord-001835-0s7ok4uw	519	6	inteins	intein	NNS
cord-001835-0s7ok4uw	519	7	as	as	IN
cord-001835-0s7ok4uw	519	8	traceless	traceless	JJ
cord-001835-0s7ok4uw	519	9	,	,	,
cord-001835-0s7ok4uw	519	10	cleavable	cleavable	JJ
cord-001835-0s7ok4uw	519	11	purification	purification	NN
cord-001835-0s7ok4uw	519	12	tags	tag	NNS
cord-001835-0s7ok4uw	519	13	enables	enable	VBZ
cord-001835-0s7ok4uw	519	14	the	the	DT
cord-001835-0s7ok4uw	519	15	separation	separation	NN
cord-001835-0s7ok4uw	519	16	of	of	IN
cord-001835-0s7ok4uw	519	17	full	full	JJ
cord-001835-0s7ok4uw	519	18	length	length	NN
cord-001835-0s7ok4uw	519	19	unnatural	unnatural	JJ
cord-001835-0s7ok4uw	519	20	amino	amino	NN
cord-001835-0s7ok4uw	519	21	acid	acid	NN
cord-001835-0s7ok4uw	519	22	(	(	-LRB-
cord-001835-0s7ok4uw	519	23	Uaa	Uaa	NNP
cord-001835-0s7ok4uw	519	24	)	)	-RRB-
cord-001835-0s7ok4uw	519	25	containing	contain	VBG
cord-001835-0s7ok4uw	519	26	proteins	protein	NNS
cord-001835-0s7ok4uw	519	27	from	from	IN
cord-001835-0s7ok4uw	519	28	their	-PRON-	PRP$
cord-001835-0s7ok4uw	519	29	corresponding	corresponding	JJ
cord-001835-0s7ok4uw	519	30	truncation	truncation	NN
cord-001835-0s7ok4uw	519	31	products	product	NNS
cord-001835-0s7ok4uw	519	32	.	.	.
cord-001835-0s7ok4uw	520	1	This	this	DT
cord-001835-0s7ok4uw	520	2	method	method	NN
cord-001835-0s7ok4uw	520	3	has	have	VBZ
cord-001835-0s7ok4uw	520	4	been	be	VBN
cord-001835-0s7ok4uw	520	5	used	use	VBN
cord-001835-0s7ok4uw	520	6	to	to	TO
cord-001835-0s7ok4uw	520	7	incorporate	incorporate	VB
cord-001835-0s7ok4uw	520	8	Uaas	Uaas	NNP
cord-001835-0s7ok4uw	520	9	in	in	IN
cord-001835-0s7ok4uw	520	10	previously	previously	RB
cord-001835-0s7ok4uw	520	11	unattainable	unattainable	JJ
cord-001835-0s7ok4uw	520	12	positions	position	NNS
cord-001835-0s7ok4uw	520	13	in	in	IN
cord-001835-0s7ok4uw	520	14	a	a	DT
cord-001835-0s7ok4uw	520	15	variety	variety	NN
cord-001835-0s7ok4uw	520	16	of	of	IN
cord-001835-0s7ok4uw	520	17	proteins	protein	NNS
cord-001835-0s7ok4uw	520	18	using	use	VBG
cord-001835-0s7ok4uw	520	19	a	a	DT
cord-001835-0s7ok4uw	520	20	myriad	myriad	NN
cord-001835-0s7ok4uw	520	21	of	of	IN
cord-001835-0s7ok4uw	520	22	Uaas	Uaas	NNP
cord-001835-0s7ok4uw	520	23	,	,	,
cord-001835-0s7ok4uw	520	24	inteins	intein	NNS
cord-001835-0s7ok4uw	520	25	,	,	,
cord-001835-0s7ok4uw	520	26	and	and	CC
cord-001835-0s7ok4uw	520	27	purification	purification	NN
cord-001835-0s7ok4uw	520	28	tags	tag	NNS
cord-001835-0s7ok4uw	520	29	.	.	.
cord-001835-0s7ok4uw	521	1	In	in	IN
cord-001835-0s7ok4uw	521	2	other	other	JJ
cord-001835-0s7ok4uw	521	3	applications	application	NNS
cord-001835-0s7ok4uw	521	4	,	,	,
cord-001835-0s7ok4uw	521	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	521	6	have	have	VBP
cord-001835-0s7ok4uw	521	7	used	use	VBN
cord-001835-0s7ok4uw	521	8	E.	E.	NNP
cord-001835-0s7ok4uw	521	9	coli	coli	NNS
cord-001835-0s7ok4uw	521	10	aminoacyl	aminoacyl	NNP
cord-001835-0s7ok4uw	521	11	transferase	transferase	NN
cord-001835-0s7ok4uw	521	12	(	(	-LRB-
cord-001835-0s7ok4uw	521	13	AaT	aat	NN
cord-001835-0s7ok4uw	521	14	)	)	-RRB-
cord-001835-0s7ok4uw	521	15	to	to	TO
cord-001835-0s7ok4uw	521	16	selectively	selectively	RB
cord-001835-0s7ok4uw	521	17	modify	modify	VB
cord-001835-0s7ok4uw	521	18	the	the	DT
cord-001835-0s7ok4uw	521	19	N	N	NNP
cord-001835-0s7ok4uw	521	20	-	-	HYPH
cord-001835-0s7ok4uw	521	21	termini	termini	NNP
cord-001835-0s7ok4uw	521	22	of	of	IN
cord-001835-0s7ok4uw	521	23	proteins	protein	NNS
cord-001835-0s7ok4uw	521	24	with	with	IN
cord-001835-0s7ok4uw	521	25	Uaas	Uaas	NNP
cord-001835-0s7ok4uw	521	26	in	in	IN
cord-001835-0s7ok4uw	521	27	denaturing	denaturing	JJ
cord-001835-0s7ok4uw	521	28	conditions	condition	NNS
cord-001835-0s7ok4uw	521	29	and	and	CC
cord-001835-0s7ok4uw	521	30	conditions	condition	NNS
cord-001835-0s7ok4uw	521	31	that	that	WDT
cord-001835-0s7ok4uw	521	32	maintain	maintain	VBP
cord-001835-0s7ok4uw	521	33	folding	folding	NN
cord-001835-0s7ok4uw	521	34	.	.	.
cord-001835-0s7ok4uw	522	1	Applications	application	NNS
cord-001835-0s7ok4uw	522	2	of	of	IN
cord-001835-0s7ok4uw	522	3	particular	particular	JJ
cord-001835-0s7ok4uw	522	4	interest	interest	NN
cord-001835-0s7ok4uw	522	5	include	include	VBP
cord-001835-0s7ok4uw	522	6	overcoming	overcome	VBG
cord-001835-0s7ok4uw	522	7	the	the	DT
cord-001835-0s7ok4uw	522	8	need	need	NN
cord-001835-0s7ok4uw	522	9	for	for	IN
cord-001835-0s7ok4uw	522	10	an	an	DT
cord-001835-0s7ok4uw	522	11	N	n	CD
cord-001835-0s7ok4uw	522	12	-	-	HYPH
cord-001835-0s7ok4uw	522	13	terminal	terminal	JJ
cord-001835-0s7ok4uw	522	14	Cys	Cys	NNP
cord-001835-0s7ok4uw	522	15	residue	residue	NN
cord-001835-0s7ok4uw	522	16	in	in	IN
cord-001835-0s7ok4uw	522	17	expressed	express	VBD
cord-001835-0s7ok4uw	522	18	protein	protein	NN
cord-001835-0s7ok4uw	522	19	ligation	ligation	NN
cord-001835-0s7ok4uw	522	20	,	,	,
cord-001835-0s7ok4uw	522	21	transfer	transfer	NN
cord-001835-0s7ok4uw	522	22	of	of	IN
cord-001835-0s7ok4uw	522	23	reactive	reactive	JJ
cord-001835-0s7ok4uw	522	24	handles	handle	NNS
cord-001835-0s7ok4uw	522	25	for	for	IN
cord-001835-0s7ok4uw	522	26	"	"	``
cord-001835-0s7ok4uw	522	27	click	click	VB
cord-001835-0s7ok4uw	522	28	"	"	''
cord-001835-0s7ok4uw	522	29	chemistry	chemistry	NN
cord-001835-0s7ok4uw	522	30	labeling	labeling	NN
cord-001835-0s7ok4uw	522	31	of	of	IN
cord-001835-0s7ok4uw	522	32	proteins	protein	NNS
cord-001835-0s7ok4uw	522	33	,	,	,
cord-001835-0s7ok4uw	522	34	and	and	CC
cord-001835-0s7ok4uw	522	35	transfer	transfer	NN
cord-001835-0s7ok4uw	522	36	of	of	IN
cord-001835-0s7ok4uw	522	37	fluorogenic	fluorogenic	JJ
cord-001835-0s7ok4uw	522	38	molecules	molecule	NNS
cord-001835-0s7ok4uw	522	39	for	for	IN
cord-001835-0s7ok4uw	522	40	photophysical	photophysical	JJ
cord-001835-0s7ok4uw	522	41	experiments	experiment	NNS
cord-001835-0s7ok4uw	522	42	.	.	.
cord-001835-0s7ok4uw	523	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	523	2	have	have	VBP
cord-001835-0s7ok4uw	523	3	found	find	VBN
cord-001835-0s7ok4uw	523	4	that	that	IN
cord-001835-0s7ok4uw	523	5	AaT	aat	NN
cord-001835-0s7ok4uw	523	6	can	can	MD
cord-001835-0s7ok4uw	523	7	transfer	transfer	VB
cord-001835-0s7ok4uw	523	8	protected	protect	VBN
cord-001835-0s7ok4uw	523	9	cysteine	cysteine	NN
cord-001835-0s7ok4uw	523	10	,	,	,
cord-001835-0s7ok4uw	523	11	homocysteine	homocysteine	NN
cord-001835-0s7ok4uw	523	12	,	,	,
cord-001835-0s7ok4uw	523	13	and	and	CC
cord-001835-0s7ok4uw	523	14	selenocysteine	selenocysteine	NN
cord-001835-0s7ok4uw	523	15	to	to	IN
cord-001835-0s7ok4uw	523	16	expressed	express	VBD
cord-001835-0s7ok4uw	523	17	proteins	protein	NNS
cord-001835-0s7ok4uw	523	18	.	.	.
cord-001835-0s7ok4uw	524	1	After	after	IN
cord-001835-0s7ok4uw	524	2	ligation	ligation	NN
cord-001835-0s7ok4uw	524	3	,	,	,
cord-001835-0s7ok4uw	524	4	these	these	DT
cord-001835-0s7ok4uw	524	5	residues	residue	NNS
cord-001835-0s7ok4uw	524	6	can	can	MD
cord-001835-0s7ok4uw	524	7	be	be	VB
cord-001835-0s7ok4uw	524	8	converted	convert	VBN
cord-001835-0s7ok4uw	524	9	to	to	IN
cord-001835-0s7ok4uw	524	10	Met	Met	NNP
cord-001835-0s7ok4uw	524	11	or	or	CC
cord-001835-0s7ok4uw	524	12	Ala	Ala	NNP
cord-001835-0s7ok4uw	524	13	,	,	,
cord-001835-0s7ok4uw	524	14	making	make	VBG
cord-001835-0s7ok4uw	524	15	the	the	DT
cord-001835-0s7ok4uw	524	16	ligation	ligation	NN
cord-001835-0s7ok4uw	524	17	traceless	traceless	NN
cord-001835-0s7ok4uw	524	18	.	.	.
cord-001835-0s7ok4uw	525	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	525	2	continue	continue	VBP
cord-001835-0s7ok4uw	525	3	to	to	TO
cord-001835-0s7ok4uw	525	4	develop	develop	VB
cord-001835-0s7ok4uw	525	5	variants	variant	NNS
cord-001835-0s7ok4uw	525	6	of	of	IN
cord-001835-0s7ok4uw	525	7	AaT	aat	NN
cord-001835-0s7ok4uw	525	8	to	to	TO
cord-001835-0s7ok4uw	525	9	broaden	broaden	VB
cord-001835-0s7ok4uw	525	10	the	the	DT
cord-001835-0s7ok4uw	525	11	substrate	substrate	JJ
cord-001835-0s7ok4uw	525	12	scope	scope	NN
cord-001835-0s7ok4uw	525	13	of	of	IN
cord-001835-0s7ok4uw	525	14	both	both	CC
cord-001835-0s7ok4uw	525	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	525	16	transferred	transfer	VBN
cord-001835-0s7ok4uw	525	17	substrate	substrate	NN
cord-001835-0s7ok4uw	525	18	and	and	CC
cord-001835-0s7ok4uw	525	19	N	n	CD
cord-001835-0s7ok4uw	525	20	-	-	HYPH
cord-001835-0s7ok4uw	525	21	terminal	terminal	NN
cord-001835-0s7ok4uw	525	22	recognition	recognition	NN
cord-001835-0s7ok4uw	525	23	element	element	NN
cord-001835-0s7ok4uw	525	24	.	.	.
cord-001835-0s7ok4uw	526	1	In	in	IN
cord-001835-0s7ok4uw	526	2	addition	addition	NN
cord-001835-0s7ok4uw	526	3	,	,	,
cord-001835-0s7ok4uw	526	4	expressed	express	VBD
cord-001835-0s7ok4uw	526	5	protein	protein	NN
cord-001835-0s7ok4uw	526	6	ligation	ligation	NN
cord-001835-0s7ok4uw	526	7	is	be	VBZ
cord-001835-0s7ok4uw	526	8	being	be	VBG
cord-001835-0s7ok4uw	526	9	used	use	VBN
cord-001835-0s7ok4uw	526	10	to	to	TO
cord-001835-0s7ok4uw	526	11	incorporate	incorporate	VB
cord-001835-0s7ok4uw	526	12	backbone	backbone	NN
cord-001835-0s7ok4uw	526	13	modifications	modification	NNS
cord-001835-0s7ok4uw	526	14	,	,	,
cord-001835-0s7ok4uw	526	15	such	such	JJ
cord-001835-0s7ok4uw	526	16	as	as	IN
cord-001835-0s7ok4uw	526	17	the	the	DT
cord-001835-0s7ok4uw	526	18	thioamide	thioamide	NNP
cord-001835-0s7ok4uw	526	19	,	,	,
cord-001835-0s7ok4uw	526	20	into	into	IN
cord-001835-0s7ok4uw	526	21	various	various	JJ
cord-001835-0s7ok4uw	526	22	positions	position	NNS
cord-001835-0s7ok4uw	526	23	in	in	IN
cord-001835-0s7ok4uw	526	24	the	the	DT
cord-001835-0s7ok4uw	526	25	protein	protein	NN
cord-001835-0s7ok4uw	526	26	calmodulin	calmodulin	NN
cord-001835-0s7ok4uw	526	27	to	to	TO
cord-001835-0s7ok4uw	526	28	determine	determine	VB
cord-001835-0s7ok4uw	526	29	how	how	WRB
cord-001835-0s7ok4uw	526	30	these	these	DT
cord-001835-0s7ok4uw	526	31	modifications	modification	NNS
cord-001835-0s7ok4uw	526	32	can	can	MD
cord-001835-0s7ok4uw	526	33	impact	impact	VB
cord-001835-0s7ok4uw	526	34	the	the	DT
cord-001835-0s7ok4uw	526	35	structure	structure	NN
cord-001835-0s7ok4uw	526	36	and	and	CC
cord-001835-0s7ok4uw	526	37	function	function	NN
cord-001835-0s7ok4uw	526	38	of	of	IN
cord-001835-0s7ok4uw	526	39	an	an	DT
cord-001835-0s7ok4uw	526	40	ordered	order	VBN
cord-001835-0s7ok4uw	526	41	protein	protein	NN
cord-001835-0s7ok4uw	526	42	.	.	.
cord-001835-0s7ok4uw	527	1	In	in	IN
cord-001835-0s7ok4uw	527	2	general	general	JJ
cord-001835-0s7ok4uw	527	3	,	,	,
cord-001835-0s7ok4uw	527	4	by	by	IN
cord-001835-0s7ok4uw	527	5	working	work	VBG
cord-001835-0s7ok4uw	527	6	at	at	IN
cord-001835-0s7ok4uw	527	7	the	the	DT
cord-001835-0s7ok4uw	527	8	interface	interface	NN
cord-001835-0s7ok4uw	527	9	of	of	IN
cord-001835-0s7ok4uw	527	10	several	several	JJ
cord-001835-0s7ok4uw	527	11	protein	protein	NN
cord-001835-0s7ok4uw	527	12	modification	modification	NN
cord-001835-0s7ok4uw	527	13	technologies	technology	NNS
cord-001835-0s7ok4uw	527	14	,	,	,
cord-001835-0s7ok4uw	527	15	we	-PRON-	PRP
cord-001835-0s7ok4uw	527	16	have	have	VBP
cord-001835-0s7ok4uw	527	17	made	make	VBN
cord-001835-0s7ok4uw	527	18	beneficial	beneficial	JJ
cord-001835-0s7ok4uw	527	19	discoveries	discovery	NNS
cord-001835-0s7ok4uw	527	20	that	that	WDT
cord-001835-0s7ok4uw	527	21	might	may	MD
cord-001835-0s7ok4uw	527	22	be	be	VB
cord-001835-0s7ok4uw	527	23	missed	miss	VBN
cord-001835-0s7ok4uw	527	24	by	by	IN
cord-001835-0s7ok4uw	527	25	more	more	RBR
cord-001835-0s7ok4uw	527	26	focused	focused	JJ
cord-001835-0s7ok4uw	527	27	approaches	approach	NNS
cord-001835-0s7ok4uw	527	28	.	.	.
cord-001835-0s7ok4uw	528	1	Function	function	NN
cord-001835-0s7ok4uw	528	2	and	and	CC
cord-001835-0s7ok4uw	528	3	modularity	modularity	NN
cord-001835-0s7ok4uw	528	4	of	of	IN
cord-001835-0s7ok4uw	528	5	CW_7	CW_7	NNP
cord-001835-0s7ok4uw	528	6	motives	motive	NNS
cord-001835-0s7ok4uw	528	7	in	in	IN
cord-001835-0s7ok4uw	528	8	the	the	DT
cord-001835-0s7ok4uw	528	9	C	C	NNP
cord-001835-0s7ok4uw	528	10	-	-	HYPH
cord-001835-0s7ok4uw	528	11	terminal	terminal	NN
cord-001835-0s7ok4uw	528	12	region	region	NN
cord-001835-0s7ok4uw	528	13	of	of	IN
cord-001835-0s7ok4uw	528	14	the	the	DT
cord-001835-0s7ok4uw	528	15	endolysin	endolysin	NNP
cord-001835-0s7ok4uw	528	16	Cpl-7	Cpl-7	NNP
cord-001835-0s7ok4uw	528	17	encoded	encode	VBN
cord-001835-0s7ok4uw	528	18	by	by	IN
cord-001835-0s7ok4uw	528	19	the	the	DT
cord-001835-0s7ok4uw	528	20	Cp7	cp7	JJ
cord-001835-0s7ok4uw	528	21	pneumococcal	pneumococcal	JJ
cord-001835-0s7ok4uw	528	22	bacteriophage	bacteriophage	NN
cord-001835-0s7ok4uw	528	23	Manuel	Manuel	NNP
cord-001835-0s7ok4uw	528	24	Iglesias	Iglesias	NNP
cord-001835-0s7ok4uw	528	25	-	-	HYPH
cord-001835-0s7ok4uw	528	26	Bexiga	Bexiga	NNP
cord-001835-0s7ok4uw	528	27	1,2	1,2	CD
cord-001835-0s7ok4uw	529	1	,	,	,
cord-001835-0s7ok4uw	529	2	Noelia	Noelia	NNP
cord-001835-0s7ok4uw	529	3	Bernardo	Bernardo	NNP
cord-001835-0s7ok4uw	529	4	-	-	HYPH
cord-001835-0s7ok4uw	529	5	Garc	Garc	NNP
cord-001835-0s7ok4uw	529	6	ıa	ıa	VBZ
cord-001835-0s7ok4uw	529	7	3	3	CD
cord-001835-0s7ok4uw	529	8	,	,	,
cord-001835-0s7ok4uw	530	1	Rub	rub	VB
cord-001835-0s7ok4uw	530	2	en	en	IN
cord-001835-0s7ok4uw	530	3	Mart	Mart	NNP
cord-001835-0s7ok4uw	530	4	ınez	ınez	NN
cord-001835-0s7ok4uw	530	5	-	-	HYPH
cord-001835-0s7ok4uw	530	6	Buey	Buey	NNP
cord-001835-0s7ok4uw	530	7	4	4	CD
cord-001835-0s7ok4uw	530	8	,	,	,
cord-001835-0s7ok4uw	530	9	Noem	Noem	NNP
cord-001835-0s7ok4uw	530	10	ı	ı	NNP
cord-001835-0s7ok4uw	531	1	Bustamante	Bustamante	NNP
cord-001835-0s7ok4uw	531	2	1,2	1,2	CD
cord-001835-0s7ok4uw	531	3	,	,	,
cord-001835-0s7ok4uw	531	4	Guadalupe	Guadalupe	NNP
cord-001835-0s7ok4uw	531	5	Garc	Garc	NNP
cord-001835-0s7ok4uw	531	6	ıa	ıa	VBZ
cord-001835-0s7ok4uw	531	7	1,2	1,2	CD
cord-001835-0s7ok4uw	531	8	,	,	,
cord-001835-0s7ok4uw	531	9	Marta	Marta	NNP
cord-001835-0s7ok4uw	531	10	Bruix	Bruix	NNP
cord-001835-0s7ok4uw	531	11	1	1	CD
cord-001835-0s7ok4uw	531	12	,	,	,
cord-001835-0s7ok4uw	531	13	Juan	Juan	NNP
cord-001835-0s7ok4uw	531	14	Hermoso	Hermoso	NNP
cord-001835-0s7ok4uw	531	15	3	3	CD
cord-001835-0s7ok4uw	531	16	,	,	,
cord-001835-0s7ok4uw	531	17	Margarita	Margarita	NNP
cord-001835-0s7ok4uw	531	18	Men	Men	NNPS
cord-001835-0s7ok4uw	531	19	endez	endez	NNP
cord-001835-0s7ok4uw	531	20	1,2	1,2	CD
cord-001835-0s7ok4uw	531	21	1	1	CD
cord-001835-0s7ok4uw	531	22	Dept	Dept	NNP
cord-001835-0s7ok4uw	531	23	.	.	.
cord-001835-0s7ok4uw	532	1	of	of	IN
cord-001835-0s7ok4uw	532	2	Biological	Biological	NNP
cord-001835-0s7ok4uw	532	3	Physical	Physical	NNP
cord-001835-0s7ok4uw	532	4	-	-	HYPH
cord-001835-0s7ok4uw	532	5	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	532	6	,	,	,
cord-001835-0s7ok4uw	532	7	IQFR	IQFR	NNP
cord-001835-0s7ok4uw	532	8	-	-	HYPH
cord-001835-0s7ok4uw	532	9	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	532	10	,	,	,
cord-001835-0s7ok4uw	532	11	2	2	CD
cord-001835-0s7ok4uw	532	12	Ciber	Ciber	NNP
cord-001835-0s7ok4uw	532	13	of	of	IN
cord-001835-0s7ok4uw	532	14	Respiratory	Respiratory	NNP
cord-001835-0s7ok4uw	532	15	Diseases	Diseases	NNPS
cord-001835-0s7ok4uw	532	16	(	(	-LRB-
cord-001835-0s7ok4uw	532	17	CIBERES	CIBERES	NNP
cord-001835-0s7ok4uw	532	18	)	)	-RRB-
cord-001835-0s7ok4uw	532	19	,	,	,
cord-001835-0s7ok4uw	532	20	3	3	CD
cord-001835-0s7ok4uw	532	21	Department	Department	NNP
cord-001835-0s7ok4uw	532	22	of	of	IN
cord-001835-0s7ok4uw	532	23	Crystallography	Crystallography	NNP
cord-001835-0s7ok4uw	532	24	and	and	CC
cord-001835-0s7ok4uw	532	25	Structural	Structural	NNP
cord-001835-0s7ok4uw	532	26	Biology	Biology	NNP
cord-001835-0s7ok4uw	532	27	,	,	,
cord-001835-0s7ok4uw	532	28	IQFR	IQFR	NNP
cord-001835-0s7ok4uw	532	29	-	-	HYPH
cord-001835-0s7ok4uw	532	30	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	532	31	,	,	,
cord-001835-0s7ok4uw	533	1	4	4	CD
cord-001835-0s7ok4uw	533	2	 	 	_SP
cord-001835-0s7ok4uw	533	3	Bacteriophage	Bacteriophage	NNP
cord-001835-0s7ok4uw	533	4	lytic	lytic	JJ
cord-001835-0s7ok4uw	533	5	murein	murein	NNS
cord-001835-0s7ok4uw	533	6	-	-	HYPH
cord-001835-0s7ok4uw	533	7	hydrolases	hydrolase	NNS
cord-001835-0s7ok4uw	533	8	have	have	VBP
cord-001835-0s7ok4uw	533	9	been	be	VBN
cord-001835-0s7ok4uw	533	10	proposed	propose	VBN
cord-001835-0s7ok4uw	533	11	as	as	IN
cord-001835-0s7ok4uw	533	12	enzybiotics	enzybiotic	NNS
cord-001835-0s7ok4uw	533	13	,	,	,
cord-001835-0s7ok4uw	533	14	an	an	DT
cord-001835-0s7ok4uw	533	15	efficient	efficient	JJ
cord-001835-0s7ok4uw	533	16	way	way	NN
cord-001835-0s7ok4uw	533	17	to	to	TO
cord-001835-0s7ok4uw	533	18	fight	fight	VB
cord-001835-0s7ok4uw	533	19	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	533	20	infections	infection	NNS
cord-001835-0s7ok4uw	533	21	.	.	.
cord-001835-0s7ok4uw	534	1	However	however	RB
cord-001835-0s7ok4uw	534	2	,	,	,
cord-001835-0s7ok4uw	534	3	the	the	DT
cord-001835-0s7ok4uw	534	4	use	use	NN
cord-001835-0s7ok4uw	534	5	of	of	IN
cord-001835-0s7ok4uw	534	6	these	these	DT
cord-001835-0s7ok4uw	534	7	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	534	8	is	be	VBZ
cord-001835-0s7ok4uw	534	9	normally	normally	RB
cord-001835-0s7ok4uw	534	10	restricted	restrict	VBN
cord-001835-0s7ok4uw	534	11	to	to	IN
cord-001835-0s7ok4uw	534	12	Gram	gram	NN
cord-001835-0s7ok4uw	534	13	-	-	HYPH
cord-001835-0s7ok4uw	534	14	positive	positive	JJ
cord-001835-0s7ok4uw	534	15	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	534	16	since	since	IN
cord-001835-0s7ok4uw	534	17	the	the	DT
cord-001835-0s7ok4uw	534	18	outer	outer	JJ
cord-001835-0s7ok4uw	534	19	membrane	membrane	NN
cord-001835-0s7ok4uw	534	20	of	of	IN
cord-001835-0s7ok4uw	534	21	the	the	DT
cord-001835-0s7ok4uw	534	22	Gram	gram	NN
cord-001835-0s7ok4uw	534	23	-	-	HYPH
cord-001835-0s7ok4uw	534	24	negative	negative	JJ
cord-001835-0s7ok4uw	534	25	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	534	26	hampers	hamper	VBZ
cord-001835-0s7ok4uw	534	27	the	the	DT
cord-001835-0s7ok4uw	534	28	access	access	NN
cord-001835-0s7ok4uw	534	29	of	of	IN
cord-001835-0s7ok4uw	534	30	the	the	DT
cord-001835-0s7ok4uw	534	31	hydrolases	hydrolase	NNS
cord-001835-0s7ok4uw	534	32	to	to	IN
cord-001835-0s7ok4uw	534	33	the	the	DT
cord-001835-0s7ok4uw	534	34	peptidoglycan	peptidoglycan	NN
cord-001835-0s7ok4uw	534	35	substrates	substrate	NNS
cord-001835-0s7ok4uw	534	36	.	.	.
cord-001835-0s7ok4uw	535	1	All	all	PDT
cord-001835-0s7ok4uw	535	2	the	the	DT
cord-001835-0s7ok4uw	535	3	murein	murein	NNP
cord-001835-0s7ok4uw	535	4	hydrolases	hydrolase	NNS
cord-001835-0s7ok4uw	535	5	reported	report	VBN
cord-001835-0s7ok4uw	535	6	in	in	IN
cord-001835-0s7ok4uw	535	7	the	the	DT
cord-001835-0s7ok4uw	535	8	pneumococcal	pneumococcal	JJ
cord-001835-0s7ok4uw	535	9	system	system	NN
cord-001835-0s7ok4uw	535	10	,	,	,
cord-001835-0s7ok4uw	535	11	both	both	CC
cord-001835-0s7ok4uw	535	12	from	from	IN
cord-001835-0s7ok4uw	535	13	host	host	NN
cord-001835-0s7ok4uw	535	14	or	or	CC
cord-001835-0s7ok4uw	535	15	phage	phage	NN
cord-001835-0s7ok4uw	535	16	origin	origin	NN
cord-001835-0s7ok4uw	535	17	,	,	,
cord-001835-0s7ok4uw	535	18	depend	depend	VB
cord-001835-0s7ok4uw	535	19	on	on	IN
cord-001835-0s7ok4uw	535	20	the	the	DT
cord-001835-0s7ok4uw	535	21	aminoalcohol	aminoalcohol	NNP
cord-001835-0s7ok4uw	535	22	choline	choline	NN
cord-001835-0s7ok4uw	535	23	to	to	TO
cord-001835-0s7ok4uw	535	24	be	be	VB
cord-001835-0s7ok4uw	535	25	fully	fully	RB
cord-001835-0s7ok4uw	535	26	active	active	JJ
cord-001835-0s7ok4uw	535	27	.	.	.
cord-001835-0s7ok4uw	536	1	There	there	EX
cord-001835-0s7ok4uw	536	2	is	be	VBZ
cord-001835-0s7ok4uw	536	3	only	only	RB
cord-001835-0s7ok4uw	536	4	a	a	DT
cord-001835-0s7ok4uw	536	5	unique	unique	JJ
cord-001835-0s7ok4uw	536	6	exception	exception	NN
cord-001835-0s7ok4uw	536	7	to	to	IN
cord-001835-0s7ok4uw	536	8	this	this	DT
cord-001835-0s7ok4uw	536	9	rule	rule	NN
cord-001835-0s7ok4uw	536	10	,	,	,
cord-001835-0s7ok4uw	536	11	the	the	DT
cord-001835-0s7ok4uw	536	12	Cpl-7	Cpl-7	NNP
cord-001835-0s7ok4uw	536	13	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	536	14	.	.	.
cord-001835-0s7ok4uw	537	1	This	this	DT
cord-001835-0s7ok4uw	537	2	hydrolase	hydrolase	NN
cord-001835-0s7ok4uw	537	3	is	be	VBZ
cord-001835-0s7ok4uw	537	4	encoded	encode	VBN
cord-001835-0s7ok4uw	537	5	by	by	IN
cord-001835-0s7ok4uw	537	6	the	the	DT
cord-001835-0s7ok4uw	537	7	lytic	lytic	JJ
cord-001835-0s7ok4uw	537	8	pneumococcal	pneumococcal	JJ
cord-001835-0s7ok4uw	537	9	phage	phage	NN
cord-001835-0s7ok4uw	537	10	Cp-7	Cp-7	NNP
cord-001835-0s7ok4uw	537	11	and	and	CC
cord-001835-0s7ok4uw	537	12	,	,	,
cord-001835-0s7ok4uw	537	13	instead	instead	RB
cord-001835-0s7ok4uw	537	14	of	of	IN
cord-001835-0s7ok4uw	537	15	the	the	DT
cord-001835-0s7ok4uw	537	16	common	common	JJ
cord-001835-0s7ok4uw	537	17	cell	cell	NN
cord-001835-0s7ok4uw	537	18	wall	wall	NN
cord-001835-0s7ok4uw	537	19	binding	bind	VBG
cord-001835-0s7ok4uw	537	20	module	module	NN
cord-001835-0s7ok4uw	537	21	(	(	-LRB-
cord-001835-0s7ok4uw	537	22	CWBM	CWBM	NNP
cord-001835-0s7ok4uw	537	23	)	)	-RRB-
cord-001835-0s7ok4uw	537	24	that	that	WDT
cord-001835-0s7ok4uw	537	25	recognizes	recognize	VBZ
cord-001835-0s7ok4uw	537	26	choline	choline	NN
cord-001835-0s7ok4uw	537	27	,	,	,
cord-001835-0s7ok4uw	537	28	Cpl-7	Cpl-7	NNP
cord-001835-0s7ok4uw	537	29	harbors	harbor	VBZ
cord-001835-0s7ok4uw	537	30	a	a	DT
cord-001835-0s7ok4uw	537	31	completely	completely	RB
cord-001835-0s7ok4uw	537	32	different	different	JJ
cord-001835-0s7ok4uw	537	33	cell	cell	NN
cord-001835-0s7ok4uw	537	34	wall	wall	NN
cord-001835-0s7ok4uw	537	35	binding	bind	VBG
cord-001835-0s7ok4uw	537	36	structure	structure	NN
cord-001835-0s7ok4uw	537	37	.	.	.
cord-001835-0s7ok4uw	538	1	Recent	recent	JJ
cord-001835-0s7ok4uw	538	2	studies	study	NNS
cord-001835-0s7ok4uw	538	3	have	have	VBP
cord-001835-0s7ok4uw	538	4	revealed	reveal	VBN
cord-001835-0s7ok4uw	538	5	that	that	IN
cord-001835-0s7ok4uw	538	6	reducing	reduce	VBG
cord-001835-0s7ok4uw	538	7	the	the	DT
cord-001835-0s7ok4uw	538	8	net	net	JJ
cord-001835-0s7ok4uw	538	9	charge	charge	NN
cord-001835-0s7ok4uw	538	10	of	of	IN
cord-001835-0s7ok4uw	538	11	the	the	DT
cord-001835-0s7ok4uw	538	12	CWBM	CWBM	NNP
cord-001835-0s7ok4uw	538	13	,	,	,
cord-001835-0s7ok4uw	538	14	from	from	IN
cord-001835-0s7ok4uw	538	15	214.9	214.9	CD
cord-001835-0s7ok4uw	538	16	to	to	IN
cord-001835-0s7ok4uw	538	17	13.0	13.0	CD
cord-001835-0s7ok4uw	538	18	,	,	,
cord-001835-0s7ok4uw	538	19	leads	lead	VBZ
cord-001835-0s7ok4uw	538	20	to	to	IN
cord-001835-0s7ok4uw	538	21	an	an	DT
cord-001835-0s7ok4uw	538	22	improvement	improvement	NN
cord-001835-0s7ok4uw	538	23	in	in	IN
cord-001835-0s7ok4uw	538	24	the	the	DT
cord-001835-0s7ok4uw	538	25	antibacterial	antibacterial	JJ
cord-001835-0s7ok4uw	538	26	activity	activity	NN
cord-001835-0s7ok4uw	538	27	of	of	IN
cord-001835-0s7ok4uw	538	28	Cpl-7	Cpl-7	NNP
cord-001835-0s7ok4uw	538	29	(	(	-LRB-
cord-001835-0s7ok4uw	538	30	1	1	CD
cord-001835-0s7ok4uw	538	31	)	)	-RRB-
cord-001835-0s7ok4uw	538	32	.	.	.
cord-001835-0s7ok4uw	539	1	The	the	DT
cord-001835-0s7ok4uw	539	2	CWBM	CWBM	NNP
cord-001835-0s7ok4uw	539	3	of	of	IN
cord-001835-0s7ok4uw	539	4	Cpl-7	Cpl-7	NNP
cord-001835-0s7ok4uw	539	5	is	be	VBZ
cord-001835-0s7ok4uw	539	6	composed	compose	VBN
cord-001835-0s7ok4uw	539	7	by	by	IN
cord-001835-0s7ok4uw	539	8	three	three	CD
cord-001835-0s7ok4uw	539	9	identical	identical	JJ
cord-001835-0s7ok4uw	539	10	repeats	repeat	NNS
cord-001835-0s7ok4uw	539	11	of	of	IN
cord-001835-0s7ok4uw	539	12	48	48	CD
cord-001835-0s7ok4uw	539	13	amino	amino	JJ
cord-001835-0s7ok4uw	539	14	acids	acid	NNS
cord-001835-0s7ok4uw	539	15	,	,	,
cord-001835-0s7ok4uw	539	16	the	the	DT
cord-001835-0s7ok4uw	539	17	CW_7	CW_7	NNP
cord-001835-0s7ok4uw	539	18	motives	motive	NNS
cord-001835-0s7ok4uw	539	19	,	,	,
cord-001835-0s7ok4uw	539	20	and	and	CC
cord-001835-0s7ok4uw	539	21	it	-PRON-	PRP
cord-001835-0s7ok4uw	539	22	folds	fold	VBZ
cord-001835-0s7ok4uw	539	23	both	both	DT
cord-001835-0s7ok4uw	539	24	in	in	IN
cord-001835-0s7ok4uw	539	25	the	the	DT
cord-001835-0s7ok4uw	539	26	presence	presence	NN
cord-001835-0s7ok4uw	539	27	and	and	CC
cord-001835-0s7ok4uw	539	28	in	in	IN
cord-001835-0s7ok4uw	539	29	the	the	DT
cord-001835-0s7ok4uw	539	30	absence	absence	NN
cord-001835-0s7ok4uw	539	31	of	of	IN
cord-001835-0s7ok4uw	539	32	the	the	DT
cord-001835-0s7ok4uw	539	33	N	n	CD
cord-001835-0s7ok4uw	539	34	-	-	HYPH
cord-001835-0s7ok4uw	539	35	terminal	terminal	JJ
cord-001835-0s7ok4uw	539	36	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	539	37	module	module	NN
cord-001835-0s7ok4uw	539	38	(	(	-LRB-
cord-001835-0s7ok4uw	539	39	2	2	CD
cord-001835-0s7ok4uw	539	40	)	)	-RRB-
cord-001835-0s7ok4uw	539	41	.	.	.
cord-001835-0s7ok4uw	540	1	This	this	DT
cord-001835-0s7ok4uw	540	2	module	module	NN
cord-001835-0s7ok4uw	540	3	shows	show	VBZ
cord-001835-0s7ok4uw	540	4	the	the	DT
cord-001835-0s7ok4uw	540	5	capacity	capacity	NN
cord-001835-0s7ok4uw	540	6	of	of	IN
cord-001835-0s7ok4uw	540	7	recognize	recognize	VB
cord-001835-0s7ok4uw	540	8	the	the	DT
cord-001835-0s7ok4uw	540	9	GlcNAc	GlcNAc	NNP
cord-001835-0s7ok4uw	540	10	-	-	HYPH
cord-001835-0s7ok4uw	540	11	MurNAc	MurNAc	NNP
cord-001835-0s7ok4uw	540	12	-	-	HYPH
cord-001835-0s7ok4uw	540	13	L	L	NNP
cord-001835-0s7ok4uw	540	14	-	-	HYPH
cord-001835-0s7ok4uw	540	15	Ala	Ala	NNP
cord-001835-0s7ok4uw	540	16	-	-	HYPH
cord-001835-0s7ok4uw	540	17	D	D	NNP
cord-001835-0s7ok4uw	540	18	-	-	HYPH
cord-001835-0s7ok4uw	540	19	isoGln	isogln	NN
cord-001835-0s7ok4uw	540	20	muropeptide	muropeptide	FW
cord-001835-0s7ok4uw	540	21	(	(	-LRB-
cord-001835-0s7ok4uw	540	22	GMDP	GMDP	NNP
cord-001835-0s7ok4uw	540	23	)	)	-RRB-
cord-001835-0s7ok4uw	540	24	,	,	,
cord-001835-0s7ok4uw	540	25	structurally	structurally	RB
cord-001835-0s7ok4uw	540	26	related	relate	VBN
cord-001835-0s7ok4uw	540	27	with	with	IN
cord-001835-0s7ok4uw	540	28	the	the	DT
cord-001835-0s7ok4uw	540	29	peptidoglycan	peptidoglycan	JJ
cord-001835-0s7ok4uw	540	30	basic	basic	JJ
cord-001835-0s7ok4uw	540	31	unit	unit	NN
cord-001835-0s7ok4uw	540	32	(	(	-LRB-
cord-001835-0s7ok4uw	540	33	3	3	CD
cord-001835-0s7ok4uw	540	34	)	)	-RRB-
cord-001835-0s7ok4uw	540	35	.	.	.
cord-001835-0s7ok4uw	541	1	Here	here	RB
cord-001835-0s7ok4uw	541	2	,	,	,
cord-001835-0s7ok4uw	541	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	541	4	report	report	VBP
cord-001835-0s7ok4uw	541	5	the	the	DT
cord-001835-0s7ok4uw	541	6	high	high	JJ
cord-001835-0s7ok4uw	541	7	resolution	resolution	NN
cord-001835-0s7ok4uw	541	8	structure	structure	NN
cord-001835-0s7ok4uw	541	9	of	of	IN
cord-001835-0s7ok4uw	541	10	the	the	DT
cord-001835-0s7ok4uw	541	11	cell	cell	NN
cord-001835-0s7ok4uw	541	12	wall	wall	NN
cord-001835-0s7ok4uw	541	13	binding	bind	VBG
cord-001835-0s7ok4uw	541	14	module	module	NN
cord-001835-0s7ok4uw	541	15	of	of	IN
cord-001835-0s7ok4uw	541	16	the	the	DT
cord-001835-0s7ok4uw	541	17	Cpl-7	Cpl-7	NNP
cord-001835-0s7ok4uw	541	18	endolysin	endolysin	NN
cord-001835-0s7ok4uw	541	19	.	.	.
cord-001835-0s7ok4uw	542	1	Each	each	DT
cord-001835-0s7ok4uw	542	2	CW_7	CW_7	NNS
cord-001835-0s7ok4uw	542	3	repeat	repeat	NN
cord-001835-0s7ok4uw	542	4	is	be	VBZ
cord-001835-0s7ok4uw	542	5	composed	compose	VBN
cord-001835-0s7ok4uw	542	6	of	of	IN
cord-001835-0s7ok4uw	542	7	a	a	DT
cord-001835-0s7ok4uw	542	8	bundle	bundle	NN
cord-001835-0s7ok4uw	542	9	of	of	IN
cord-001835-0s7ok4uw	542	10	three	three	CD
cord-001835-0s7ok4uw	542	11	a	a	DT
cord-001835-0s7ok4uw	542	12	-	-	:
cord-001835-0s7ok4uw	542	13	helices	helix	NNS
cord-001835-0s7ok4uw	542	14	with	with	IN
cord-001835-0s7ok4uw	542	15	a	a	DT
cord-001835-0s7ok4uw	542	16	highly	highly	RB
cord-001835-0s7ok4uw	542	17	negative	negative	JJ
cord-001835-0s7ok4uw	542	18	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	542	19	charge	charge	NN
cord-001835-0s7ok4uw	542	20	at	at	IN
cord-001835-0s7ok4uw	542	21	the	the	DT
cord-001835-0s7ok4uw	542	22	surface	surface	NN
cord-001835-0s7ok4uw	542	23	.	.	.
cord-001835-0s7ok4uw	543	1	The	the	DT
cord-001835-0s7ok4uw	543	2	strong	strong	JJ
cord-001835-0s7ok4uw	543	3	inter	inter	JJ
cord-001835-0s7ok4uw	543	4	-	-	JJ
cord-001835-0s7ok4uw	543	5	repeat	repeat	VB
cord-001835-0s7ok4uw	543	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	543	7	and	and	CC
cord-001835-0s7ok4uw	543	8	the	the	DT
cord-001835-0s7ok4uw	543	9	high	high	JJ
cord-001835-0s7ok4uw	543	10	ionic	ionic	JJ
cord-001835-0s7ok4uw	543	11	strength	strength	NN
cord-001835-0s7ok4uw	543	12	used	use	VBN
cord-001835-0s7ok4uw	543	13	in	in	IN
cord-001835-0s7ok4uw	543	14	the	the	DT
cord-001835-0s7ok4uw	543	15	crystallization	crystallization	NN
cord-001835-0s7ok4uw	543	16	conditions	condition	NNS
cord-001835-0s7ok4uw	543	17	allow	allow	VBP
cord-001835-0s7ok4uw	543	18	them	-PRON-	PRP
cord-001835-0s7ok4uw	543	19	overcoming	overcome	VBG
cord-001835-0s7ok4uw	543	20	the	the	DT
cord-001835-0s7ok4uw	543	21	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	543	22	repulsions	repulsion	NNS
cord-001835-0s7ok4uw	543	23	inducing	induce	VBG
cord-001835-0s7ok4uw	543	24	a	a	DT
cord-001835-0s7ok4uw	543	25	closed	close	VBN
cord-001835-0s7ok4uw	543	26	-	-	HYPH
cord-001835-0s7ok4uw	543	27	packed	pack	VBN
cord-001835-0s7ok4uw	543	28	structure	structure	NN
cord-001835-0s7ok4uw	543	29	with	with	IN
cord-001835-0s7ok4uw	543	30	a	a	DT
cord-001835-0s7ok4uw	543	31	three	three	CD
cord-001835-0s7ok4uw	543	32	-	-	HYPH
cord-001835-0s7ok4uw	543	33	fold	fold	NN
cord-001835-0s7ok4uw	543	34	symmetry	symmetry	NN
cord-001835-0s7ok4uw	543	35	.	.	.
cord-001835-0s7ok4uw	544	1	The	the	DT
cord-001835-0s7ok4uw	544	2	module	module	NN
cord-001835-0s7ok4uw	544	3	dimensions	dimension	NNS
cord-001835-0s7ok4uw	544	4	(	(	-LRB-
cord-001835-0s7ok4uw	544	5	49	49	CD
cord-001835-0s7ok4uw	544	6	x	x	SYM
cord-001835-0s7ok4uw	544	7	38	38	CD
cord-001835-0s7ok4uw	544	8	x	x	SYM
cord-001835-0s7ok4uw	544	9	34	34	CD
cord-001835-0s7ok4uw	544	10	Å	å	NN
cord-001835-0s7ok4uw	544	11	)	)	-RRB-
cord-001835-0s7ok4uw	544	12	and	and	CC
cord-001835-0s7ok4uw	544	13	the	the	DT
cord-001835-0s7ok4uw	544	14	repeat	repeat	NN
cord-001835-0s7ok4uw	544	15	arrangement	arrangement	NN
cord-001835-0s7ok4uw	544	16	in	in	IN
cord-001835-0s7ok4uw	544	17	the	the	DT
cord-001835-0s7ok4uw	544	18	crystal	crystal	NN
cord-001835-0s7ok4uw	544	19	structure	structure	NN
cord-001835-0s7ok4uw	544	20	are	be	VBP
cord-001835-0s7ok4uw	544	21	inconsistent	inconsistent	JJ
cord-001835-0s7ok4uw	544	22	with	with	IN
cord-001835-0s7ok4uw	544	23	the	the	DT
cord-001835-0s7ok4uw	544	24	GMDP	GMDP	NNP
cord-001835-0s7ok4uw	544	25	binding	bind	VBG
cord-001835-0s7ok4uw	544	26	characterization	characterization	NN
cord-001835-0s7ok4uw	544	27	,	,	,
cord-001835-0s7ok4uw	544	28	the	the	DT
cord-001835-0s7ok4uw	544	29	activity	activity	NN
cord-001835-0s7ok4uw	544	30	displayed	display	VBN
cord-001835-0s7ok4uw	544	31	by	by	IN
cord-001835-0s7ok4uw	544	32	Cpl-7	Cpl-7	NNP
cord-001835-0s7ok4uw	544	33	truncated	truncated	JJ
cord-001835-0s7ok4uw	544	34	variants	variant	NNS
cord-001835-0s7ok4uw	544	35	with	with	IN
cord-001835-0s7ok4uw	544	36	one	one	CD
cord-001835-0s7ok4uw	544	37	or	or	CC
cord-001835-0s7ok4uw	544	38	two	two	CD
cord-001835-0s7ok4uw	544	39	CW_7	CW_7	NNS
cord-001835-0s7ok4uw	544	40	repeats	repeat	VBZ
cord-001835-0s7ok4uw	544	41	,	,	,
cord-001835-0s7ok4uw	544	42	or	or	CC
cord-001835-0s7ok4uw	544	43	the	the	DT
cord-001835-0s7ok4uw	544	44	experimental	experimental	JJ
cord-001835-0s7ok4uw	544	45	determined	determine	VBD
cord-001835-0s7ok4uw	544	46	hydrodynamic	hydrodynamic	JJ
cord-001835-0s7ok4uw	544	47	properties	property	NNS
cord-001835-0s7ok4uw	544	48	.	.	.
cord-001835-0s7ok4uw	545	1	Using	use	VBG
cord-001835-0s7ok4uw	545	2	the	the	DT
cord-001835-0s7ok4uw	545	3	small	small	JJ
cord-001835-0s7ok4uw	545	4	angle	angle	NN
cord-001835-0s7ok4uw	545	5	X	x	NN
cord-001835-0s7ok4uw	545	6	-	-	NN
cord-001835-0s7ok4uw	545	7	ray	ray	NN
cord-001835-0s7ok4uw	545	8	scattering	scattering	NN
cord-001835-0s7ok4uw	545	9	(	(	-LRB-
cord-001835-0s7ok4uw	545	10	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	545	11	)	)	-RRB-
cord-001835-0s7ok4uw	545	12	technique	technique	NN
cord-001835-0s7ok4uw	545	13	and	and	CC
cord-001835-0s7ok4uw	545	14	the	the	DT
cord-001835-0s7ok4uw	545	15	ATSAS	ATSAS	NNP
cord-001835-0s7ok4uw	545	16	computational	computational	JJ
cord-001835-0s7ok4uw	545	17	platform	platform	NN
cord-001835-0s7ok4uw	545	18	(	(	-LRB-
cord-001835-0s7ok4uw	545	19	4	4	CD
cord-001835-0s7ok4uw	545	20	)	)	-RRB-
cord-001835-0s7ok4uw	545	21	,	,	,
cord-001835-0s7ok4uw	545	22	a	a	DT
cord-001835-0s7ok4uw	545	23	different	different	JJ
cord-001835-0s7ok4uw	545	24	arrangement	arrangement	NN
cord-001835-0s7ok4uw	545	25	of	of	IN
cord-001835-0s7ok4uw	545	26	the	the	DT
cord-001835-0s7ok4uw	545	27	CW_7	CW_7	NNPS
cord-001835-0s7ok4uw	545	28	repeats	repeat	VBZ
cord-001835-0s7ok4uw	545	29	is	be	VBZ
cord-001835-0s7ok4uw	545	30	envisaged	envisage	VBN
cord-001835-0s7ok4uw	545	31	in	in	IN
cord-001835-0s7ok4uw	545	32	solution	solution	NN
cord-001835-0s7ok4uw	545	33	(	(	-LRB-
cord-001835-0s7ok4uw	545	34	Fig	Fig	NNP
cord-001835-0s7ok4uw	545	35	.	.	.
cord-001835-0s7ok4uw	545	36	1	1	CD
cord-001835-0s7ok4uw	545	37	)	)	-RRB-
cord-001835-0s7ok4uw	545	38	,	,	,
cord-001835-0s7ok4uw	545	39	whose	whose	WP$
cord-001835-0s7ok4uw	545	40	rather	rather	RB
cord-001835-0s7ok4uw	545	41	opened	open	VBN
cord-001835-0s7ok4uw	545	42	structure	structure	NN
cord-001835-0s7ok4uw	545	43	(	(	-LRB-
cord-001835-0s7ok4uw	545	44	70	70	CD
cord-001835-0s7ok4uw	545	45	x	x	SYM
cord-001835-0s7ok4uw	545	46	44	44	CD
cord-001835-0s7ok4uw	545	47	x	x	SYM
cord-001835-0s7ok4uw	545	48	46	46	CD
cord-001835-0s7ok4uw	545	49	Å	å	NN
cord-001835-0s7ok4uw	545	50	)	)	-RRB-
cord-001835-0s7ok4uw	545	51	is	be	VBZ
cord-001835-0s7ok4uw	545	52	consistent	consistent	JJ
cord-001835-0s7ok4uw	545	53	with	with	IN
cord-001835-0s7ok4uw	545	54	the	the	DT
cord-001835-0s7ok4uw	545	55	experimental	experimental	JJ
cord-001835-0s7ok4uw	545	56	data	datum	NNS
cord-001835-0s7ok4uw	545	57	.	.	.
cord-001835-0s7ok4uw	546	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	546	2	,	,	,
cord-001835-0s7ok4uw	546	3	employing	employ	VBG
cord-001835-0s7ok4uw	546	4	the	the	DT
cord-001835-0s7ok4uw	546	5	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	546	6	-	-	HYPH
cord-001835-0s7ok4uw	546	7	based	base	VBN
cord-001835-0s7ok4uw	546	8	structure	structure	NN
cord-001835-0s7ok4uw	546	9	and	and	CC
cord-001835-0s7ok4uw	546	10	the	the	DT
cord-001835-0s7ok4uw	546	11	honeycomb	honeycomb	NN
cord-001835-0s7ok4uw	546	12	structure	structure	NN
cord-001835-0s7ok4uw	546	13	proposed	propose	VBN
cord-001835-0s7ok4uw	546	14	for	for	IN
cord-001835-0s7ok4uw	546	15	the	the	DT
cord-001835-0s7ok4uw	546	16	peptidoglycan	peptidoglycan	NN
cord-001835-0s7ok4uw	546	17	,	,	,
cord-001835-0s7ok4uw	546	18	a	a	DT
cord-001835-0s7ok4uw	546	19	model	model	NN
cord-001835-0s7ok4uw	546	20	,	,	,
cord-001835-0s7ok4uw	546	21	where	where	WRB
cord-001835-0s7ok4uw	546	22	each	each	DT
cord-001835-0s7ok4uw	546	23	CW_7	CW_7	NNPS
cord-001835-0s7ok4uw	546	24	repeat	repeat	VBP
cord-001835-0s7ok4uw	546	25	of	of	IN
cord-001835-0s7ok4uw	546	26	the	the	DT
cord-001835-0s7ok4uw	546	27	cell	cell	NN
cord-001835-0s7ok4uw	546	28	wall	wall	NN
cord-001835-0s7ok4uw	546	29	binding	bind	VBG
cord-001835-0s7ok4uw	546	30	module	module	NN
cord-001835-0s7ok4uw	546	31	fit	fit	VBN
cord-001835-0s7ok4uw	546	32	in	in	IN
cord-001835-0s7ok4uw	546	33	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	546	34	glycan	glycan	NN
cord-001835-0s7ok4uw	546	35	chains	chain	NNS
cord-001835-0s7ok4uw	546	36	,	,	,
cord-001835-0s7ok4uw	546	37	has	have	VBZ
cord-001835-0s7ok4uw	546	38	been	be	VBN
cord-001835-0s7ok4uw	546	39	derived	derive	VBN
cord-001835-0s7ok4uw	546	40	.	.	.
cord-001835-0s7ok4uw	546	41	 	 	_SP
cord-001835-0s7ok4uw	547	1	In	in	IN
cord-001835-0s7ok4uw	547	2	2000	2000	CD
cord-001835-0s7ok4uw	547	3	,	,	,
cord-001835-0s7ok4uw	547	4	the	the	DT
cord-001835-0s7ok4uw	547	5	Protein	Protein	NNP
cord-001835-0s7ok4uw	547	6	Structure	Structure	NNP
cord-001835-0s7ok4uw	547	7	Initiative	Initiative	NNP
cord-001835-0s7ok4uw	547	8	(	(	-LRB-
cord-001835-0s7ok4uw	547	9	PSI	PSI	NNP
cord-001835-0s7ok4uw	547	10	)	)	-RRB-
cord-001835-0s7ok4uw	547	11	was	be	VBD
cord-001835-0s7ok4uw	547	12	started	start	VBN
cord-001835-0s7ok4uw	547	13	as	as	IN
cord-001835-0s7ok4uw	547	14	to	to	TO
cord-001835-0s7ok4uw	547	15	determine	determine	VB
cord-001835-0s7ok4uw	547	16	three	three	CD
cord-001835-0s7ok4uw	547	17	-	-	HYPH
cord-001835-0s7ok4uw	547	18	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	547	19	structures	structure	NNS
cord-001835-0s7ok4uw	547	20	of	of	IN
cord-001835-0s7ok4uw	547	21	proteins	protein	NNS
cord-001835-0s7ok4uw	547	22	within	within	IN
cord-001835-0s7ok4uw	547	23	every	every	DT
cord-001835-0s7ok4uw	547	24	family	family	NN
cord-001835-0s7ok4uw	547	25	.	.	.
cord-001835-0s7ok4uw	548	1	Once	once	RB
cord-001835-0s7ok4uw	548	2	solved	solve	VBN
cord-001835-0s7ok4uw	548	3	,	,	,
cord-001835-0s7ok4uw	548	4	structures	structure	NNS
cord-001835-0s7ok4uw	548	5	are	be	VBP
cord-001835-0s7ok4uw	548	6	deposited	deposit	VBN
cord-001835-0s7ok4uw	548	7	into	into	IN
cord-001835-0s7ok4uw	548	8	the	the	DT
cord-001835-0s7ok4uw	548	9	Protein	Protein	NNP
cord-001835-0s7ok4uw	548	10	Data	Data	NNP
cord-001835-0s7ok4uw	548	11	Bank	Bank	NNP
cord-001835-0s7ok4uw	548	12	(	(	-LRB-
cord-001835-0s7ok4uw	548	13	PDB	PDB	NNP
cord-001835-0s7ok4uw	548	14	)	)	-RRB-
cord-001835-0s7ok4uw	548	15	and	and	CC
cord-001835-0s7ok4uw	548	16	termed	term	VBD
cord-001835-0s7ok4uw	548	17	Structural	Structural	NNP
cord-001835-0s7ok4uw	548	18	Genomics	Genomics	NNP
cord-001835-0s7ok4uw	548	19	(	(	-LRB-
cord-001835-0s7ok4uw	548	20	SG	SG	NNP
cord-001835-0s7ok4uw	548	21	)	)	-RRB-
cord-001835-0s7ok4uw	548	22	proteins	protein	NNS
cord-001835-0s7ok4uw	548	23	.	.	.
cord-001835-0s7ok4uw	549	1	As	as	IN
cord-001835-0s7ok4uw	549	2	of	of	IN
cord-001835-0s7ok4uw	549	3	June	June	NNP
cord-001835-0s7ok4uw	549	4	2015	2015	CD
cord-001835-0s7ok4uw	549	5	,	,	,
cord-001835-0s7ok4uw	549	6	there	there	EX
cord-001835-0s7ok4uw	549	7	are	be	VBP
cord-001835-0s7ok4uw	549	8	over	over	IN
cord-001835-0s7ok4uw	549	9	13,300	13,300	CD
cord-001835-0s7ok4uw	549	10	SG	SG	NNP
cord-001835-0s7ok4uw	549	11	proteins	protein	NNS
cord-001835-0s7ok4uw	549	12	deposited	deposit	VBN
cord-001835-0s7ok4uw	549	13	in	in	IN
cord-001835-0s7ok4uw	549	14	the	the	DT
cord-001835-0s7ok4uw	549	15	PDB	PDB	NNP
cord-001835-0s7ok4uw	549	16	and	and	CC
cord-001835-0s7ok4uw	549	17	most	most	JJS
cord-001835-0s7ok4uw	549	18	of	of	IN
cord-001835-0s7ok4uw	549	19	them	-PRON-	PRP
cord-001835-0s7ok4uw	549	20	are	be	VBP
cord-001835-0s7ok4uw	549	21	of	of	IN
cord-001835-0s7ok4uw	549	22	unknown	unknown	JJ
cord-001835-0s7ok4uw	549	23	or	or	CC
cord-001835-0s7ok4uw	549	24	uncertain	uncertain	JJ
cord-001835-0s7ok4uw	549	25	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	549	26	function	function	NN
cord-001835-0s7ok4uw	549	27	.	.	.
cord-001835-0s7ok4uw	550	1	In	in	IN
cord-001835-0s7ok4uw	550	2	addition	addition	NN
cord-001835-0s7ok4uw	550	3	,	,	,
cord-001835-0s7ok4uw	550	4	many	many	JJ
cord-001835-0s7ok4uw	550	5	of	of	IN
cord-001835-0s7ok4uw	550	6	these	these	DT
cord-001835-0s7ok4uw	550	7	SG	SG	NNP
cord-001835-0s7ok4uw	550	8	proteins	protein	NNS
cord-001835-0s7ok4uw	550	9	have	have	VBP
cord-001835-0s7ok4uw	550	10	a	a	DT
cord-001835-0s7ok4uw	550	11	putative	putative	JJ
cord-001835-0s7ok4uw	550	12	functional	functional	JJ
cord-001835-0s7ok4uw	550	13	assignment	assignment	NN
cord-001835-0s7ok4uw	550	14	based	base	VBN
cord-001835-0s7ok4uw	550	15	on	on	IN
cord-001835-0s7ok4uw	550	16	their	-PRON-	PRP$
cord-001835-0s7ok4uw	550	17	sequence	sequence	NN
cord-001835-0s7ok4uw	550	18	and	and	CC
cord-001835-0s7ok4uw	550	19	structural	structural	JJ
cord-001835-0s7ok4uw	550	20	similarities	similarity	NNS
cord-001835-0s7ok4uw	550	21	with	with	IN
cord-001835-0s7ok4uw	550	22	proteins	protein	NNS
cord-001835-0s7ok4uw	550	23	of	of	IN
cord-001835-0s7ok4uw	550	24	known	know	VBN
cord-001835-0s7ok4uw	550	25	function	function	NN
cord-001835-0s7ok4uw	550	26	;	;	:
cord-001835-0s7ok4uw	550	27	such	such	JJ
cord-001835-0s7ok4uw	550	28	comparisons	comparison	NNS
cord-001835-0s7ok4uw	550	29	can	can	MD
cord-001835-0s7ok4uw	550	30	be	be	VB
cord-001835-0s7ok4uw	550	31	made	make	VBN
cord-001835-0s7ok4uw	550	32	against	against	IN
cord-001835-0s7ok4uw	550	33	large	large	JJ
cord-001835-0s7ok4uw	550	34	databases	database	NNS
cord-001835-0s7ok4uw	550	35	using	use	VBG
cord-001835-0s7ok4uw	550	36	programs	program	NNS
cord-001835-0s7ok4uw	550	37	such	such	JJ
cord-001835-0s7ok4uw	550	38	as	as	IN
cord-001835-0s7ok4uw	550	39	BLAST	blast	NN
cord-001835-0s7ok4uw	550	40	or	or	CC
cord-001835-0s7ok4uw	550	41	Dali	Dali	NNP
cord-001835-0s7ok4uw	550	42	.	.	.
cord-001835-0s7ok4uw	551	1	However	however	RB
cord-001835-0s7ok4uw	551	2	,	,	,
cord-001835-0s7ok4uw	551	3	these	these	DT
cord-001835-0s7ok4uw	551	4	putative	putative	JJ
cord-001835-0s7ok4uw	551	5	functional	functional	JJ
cord-001835-0s7ok4uw	551	6	assignments	assignment	NNS
cord-001835-0s7ok4uw	551	7	are	be	VBP
cord-001835-0s7ok4uw	551	8	often	often	RB
cord-001835-0s7ok4uw	551	9	incorrect	incorrect	JJ
cord-001835-0s7ok4uw	551	10	.	.	.
cord-001835-0s7ok4uw	552	1	This	this	DT
cord-001835-0s7ok4uw	552	2	project	project	NN
cord-001835-0s7ok4uw	552	3	analyzes	analyze	VBZ
cord-001835-0s7ok4uw	552	4	members	member	NNS
cord-001835-0s7ok4uw	552	5	of	of	IN
cord-001835-0s7ok4uw	552	6	the	the	DT
cord-001835-0s7ok4uw	552	7	Crotonase	Crotonase	NNP
cord-001835-0s7ok4uw	552	8	Superfamily	Superfamily	NNP
cord-001835-0s7ok4uw	552	9	(	(	-LRB-
cord-001835-0s7ok4uw	552	10	CS	CS	NNP
cord-001835-0s7ok4uw	552	11	)	)	-RRB-
cord-001835-0s7ok4uw	552	12	.	.	.
cord-001835-0s7ok4uw	553	1	The	the	DT
cord-001835-0s7ok4uw	553	2	CS	CS	NNP
cord-001835-0s7ok4uw	553	3	consists	consist	VBZ
cord-001835-0s7ok4uw	553	4	of	of	IN
cord-001835-0s7ok4uw	553	5	five	five	CD
cord-001835-0s7ok4uw	553	6	diverse	diverse	JJ
cord-001835-0s7ok4uw	553	7	functional	functional	JJ
cord-001835-0s7ok4uw	553	8	subgroups	subgroup	NNS
cord-001835-0s7ok4uw	553	9	that	that	WDT
cord-001835-0s7ok4uw	553	10	are	be	VBP
cord-001835-0s7ok4uw	553	11	well	well	RB
cord-001835-0s7ok4uw	553	12	characterized	characterize	VBN
cord-001835-0s7ok4uw	553	13	structurally	structurally	RB
cord-001835-0s7ok4uw	553	14	and	and	CC
cord-001835-0s7ok4uw	553	15	functionally	functionally	RB
cord-001835-0s7ok4uw	553	16	,	,	,
cord-001835-0s7ok4uw	553	17	representing	represent	VBG
cord-001835-0s7ok4uw	553	18	different	different	JJ
cord-001835-0s7ok4uw	553	19	types	type	NNS
cord-001835-0s7ok4uw	553	20	of	of	IN
cord-001835-0s7ok4uw	553	21	reactivity	reactivity	NN
cord-001835-0s7ok4uw	553	22	,	,	,
cord-001835-0s7ok4uw	553	23	including	include	VBG
cord-001835-0s7ok4uw	553	24	hydrolase	hydrolase	NN
cord-001835-0s7ok4uw	553	25	,	,	,
cord-001835-0s7ok4uw	553	26	isomerase	isomerase	NN
cord-001835-0s7ok4uw	553	27	,	,	,
cord-001835-0s7ok4uw	553	28	hydratase	hydratase	NNP
cord-001835-0s7ok4uw	553	29	,	,	,
cord-001835-0s7ok4uw	553	30	and	and	CC
cord-001835-0s7ok4uw	553	31	dehalogenase	dehalogenase	NNP
cord-001835-0s7ok4uw	553	32	activities	activity	NNS
cord-001835-0s7ok4uw	553	33	.	.	.
cord-001835-0s7ok4uw	554	1	This	this	DT
cord-001835-0s7ok4uw	554	2	superfamily	superfamily	NN
cord-001835-0s7ok4uw	554	3	also	also	RB
cord-001835-0s7ok4uw	554	4	contains	contain	VBZ
cord-001835-0s7ok4uw	554	5	at	at	IN
cord-001835-0s7ok4uw	554	6	least	least	RBS
cord-001835-0s7ok4uw	554	7	70	70	CD
cord-001835-0s7ok4uw	554	8	SG	SG	NNP
cord-001835-0s7ok4uw	554	9	proteins	protein	NNS
cord-001835-0s7ok4uw	554	10	,	,	,
cord-001835-0s7ok4uw	554	11	so	so	CC
cord-001835-0s7ok4uw	554	12	it	-PRON-	PRP
cord-001835-0s7ok4uw	554	13	is	be	VBZ
cord-001835-0s7ok4uw	554	14	ideal	ideal	JJ
cord-001835-0s7ok4uw	554	15	to	to	TO
cord-001835-0s7ok4uw	554	16	test	test	VB
cord-001835-0s7ok4uw	554	17	predictions	prediction	NNS
cord-001835-0s7ok4uw	554	18	of	of	IN
cord-001835-0s7ok4uw	554	19	protein	protein	NN
cord-001835-0s7ok4uw	554	20	function	function	NN
cord-001835-0s7ok4uw	554	21	.	.	.
cord-001835-0s7ok4uw	555	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	555	2	approach	approach	NN
cord-001835-0s7ok4uw	555	3	is	be	VBZ
cord-001835-0s7ok4uw	555	4	based	base	VBN
cord-001835-0s7ok4uw	555	5	on	on	IN
cord-001835-0s7ok4uw	555	6	local	local	JJ
cord-001835-0s7ok4uw	555	7	structure	structure	NN
cord-001835-0s7ok4uw	555	8	matching	match	VBG
cord-001835-0s7ok4uw	555	9	at	at	IN
cord-001835-0s7ok4uw	555	10	the	the	DT
cord-001835-0s7ok4uw	555	11	computationally	computationally	RB
cord-001835-0s7ok4uw	555	12	predicted	predict	VBN
cord-001835-0s7ok4uw	555	13	active	active	JJ
cord-001835-0s7ok4uw	555	14	site	site	NN
cord-001835-0s7ok4uw	555	15	.	.	.
cord-001835-0s7ok4uw	556	1	First	first	RB
cord-001835-0s7ok4uw	556	2	,	,	,
cord-001835-0s7ok4uw	556	3	Partial	Partial	NNP
cord-001835-0s7ok4uw	556	4	Order	order	NN
cord-001835-0s7ok4uw	556	5	Optimum	optimum	JJ
cord-001835-0s7ok4uw	556	6	Likelihood	Likelihood	NNP
cord-001835-0s7ok4uw	556	7	(	(	-LRB-
cord-001835-0s7ok4uw	556	8	POOL	pool	NN
cord-001835-0s7ok4uw	556	9	)	)	-RRB-
cord-001835-0s7ok4uw	556	10	is	be	VBZ
cord-001835-0s7ok4uw	556	11	used	use	VBN
cord-001835-0s7ok4uw	556	12	to	to	TO
cord-001835-0s7ok4uw	556	13	predict	predict	VB
cord-001835-0s7ok4uw	556	14	the	the	DT
cord-001835-0s7ok4uw	556	15	functionally	functionally	RB
cord-001835-0s7ok4uw	556	16	important	important	JJ
cord-001835-0s7ok4uw	556	17	residues	residue	NNS
cord-001835-0s7ok4uw	556	18	of	of	IN
cord-001835-0s7ok4uw	556	19	each	each	DT
cord-001835-0s7ok4uw	556	20	SG	SG	NNP
cord-001835-0s7ok4uw	556	21	protein	protein	NN
cord-001835-0s7ok4uw	556	22	and	and	CC
cord-001835-0s7ok4uw	556	23	of	of	IN
cord-001835-0s7ok4uw	556	24	the	the	DT
cord-001835-0s7ok4uw	556	25	proteins	protein	NNS
cord-001835-0s7ok4uw	556	26	of	of	IN
cord-001835-0s7ok4uw	556	27	known	know	VBN
cord-001835-0s7ok4uw	556	28	function	function	NN
cord-001835-0s7ok4uw	556	29	in	in	IN
cord-001835-0s7ok4uw	556	30	the	the	DT
cord-001835-0s7ok4uw	556	31	superfamily	superfamily	NN
cord-001835-0s7ok4uw	556	32	.	.	.
cord-001835-0s7ok4uw	557	1	Next	next	RB
cord-001835-0s7ok4uw	557	2	,	,	,
cord-001835-0s7ok4uw	557	3	Structurally	structurally	RB
cord-001835-0s7ok4uw	557	4	Aligned	align	VBN
cord-001835-0s7ok4uw	557	5	Local	Local	NNP
cord-001835-0s7ok4uw	557	6	Sites	Sites	NNPS
cord-001835-0s7ok4uw	557	7	of	of	IN
cord-001835-0s7ok4uw	557	8	Activity	activity	NN
cord-001835-0s7ok4uw	557	9	(	(	-LRB-
cord-001835-0s7ok4uw	557	10	SALSA	SALSA	NNP
cord-001835-0s7ok4uw	557	11	)	)	-RRB-
cord-001835-0s7ok4uw	557	12	is	be	VBZ
cord-001835-0s7ok4uw	557	13	used	use	VBN
cord-001835-0s7ok4uw	557	14	to	to	TO
cord-001835-0s7ok4uw	557	15	align	align	VB
cord-001835-0s7ok4uw	557	16	the	the	DT
cord-001835-0s7ok4uw	557	17	predicted	predict	VBN
cord-001835-0s7ok4uw	557	18	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	557	19	residues	residue	NNS
cord-001835-0s7ok4uw	557	20	of	of	IN
cord-001835-0s7ok4uw	557	21	the	the	DT
cord-001835-0s7ok4uw	557	22	well	well	RB
cord-001835-0s7ok4uw	557	23	-	-	HYPH
cord-001835-0s7ok4uw	557	24	characterized	characterize	VBN
cord-001835-0s7ok4uw	557	25	members	member	NNS
cord-001835-0s7ok4uw	557	26	in	in	IN
cord-001835-0s7ok4uw	557	27	the	the	DT
cord-001835-0s7ok4uw	557	28	superfamily	superfamily	NN
cord-001835-0s7ok4uw	557	29	.	.	.
cord-001835-0s7ok4uw	558	1	From	from	IN
cord-001835-0s7ok4uw	558	2	this	this	DT
cord-001835-0s7ok4uw	558	3	analysis	analysis	NN
cord-001835-0s7ok4uw	558	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	558	5	generate	generate	VBP
cord-001835-0s7ok4uw	558	6	chemical	chemical	JJ
cord-001835-0s7ok4uw	558	7	signatures	signature	NNS
cord-001835-0s7ok4uw	558	8	for	for	IN
cord-001835-0s7ok4uw	558	9	each	each	DT
cord-001835-0s7ok4uw	558	10	functional	functional	JJ
cord-001835-0s7ok4uw	558	11	subgroup	subgroup	NN
cord-001835-0s7ok4uw	558	12	and	and	CC
cord-001835-0s7ok4uw	558	13	compare	compare	VB
cord-001835-0s7ok4uw	558	14	them	-PRON-	PRP
cord-001835-0s7ok4uw	558	15	to	to	IN
cord-001835-0s7ok4uw	558	16	the	the	DT
cord-001835-0s7ok4uw	558	17	sets	set	NNS
cord-001835-0s7ok4uw	558	18	of	of	IN
cord-001835-0s7ok4uw	558	19	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	558	20	residues	residue	NNS
cord-001835-0s7ok4uw	558	21	predicted	predict	VBN
cord-001835-0s7ok4uw	558	22	for	for	IN
cord-001835-0s7ok4uw	558	23	the	the	DT
cord-001835-0s7ok4uw	558	24	SG	SG	NNP
cord-001835-0s7ok4uw	558	25	proteins	protein	NNS
cord-001835-0s7ok4uw	558	26	.	.	.
cord-001835-0s7ok4uw	559	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	559	2	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	559	3	based	base	VBN
cord-001835-0s7ok4uw	559	4	on	on	IN
cord-001835-0s7ok4uw	559	5	these	these	DT
cord-001835-0s7ok4uw	559	6	computational	computational	JJ
cord-001835-0s7ok4uw	559	7	methods	method	NNS
cord-001835-0s7ok4uw	559	8	that	that	WDT
cord-001835-0s7ok4uw	559	9	the	the	DT
cord-001835-0s7ok4uw	559	10	majority	majority	NN
cord-001835-0s7ok4uw	559	11	of	of	IN
cord-001835-0s7ok4uw	559	12	the	the	DT
cord-001835-0s7ok4uw	559	13	putative	putative	JJ
cord-001835-0s7ok4uw	559	14	annotations	annotation	NNS
cord-001835-0s7ok4uw	559	15	in	in	IN
cord-001835-0s7ok4uw	559	16	the	the	DT
cord-001835-0s7ok4uw	559	17	CS	CS	NNP
cord-001835-0s7ok4uw	559	18	superfamily	superfamily	NN
cord-001835-0s7ok4uw	559	19	are	be	VBP
cord-001835-0s7ok4uw	559	20	likely	likely	RB
cord-001835-0s7ok4uw	559	21	incorrect	incorrect	JJ
cord-001835-0s7ok4uw	559	22	.	.	.
cord-001835-0s7ok4uw	560	1	Currently	currently	RB
cord-001835-0s7ok4uw	560	2	,	,	,
cord-001835-0s7ok4uw	560	3	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	560	4	assays	assay	NNS
cord-001835-0s7ok4uw	560	5	are	be	VBP
cord-001835-0s7ok4uw	560	6	being	be	VBG
cord-001835-0s7ok4uw	560	7	used	use	VBN
cord-001835-0s7ok4uw	560	8	to	to	TO
cord-001835-0s7ok4uw	560	9	test	test	VB
cord-001835-0s7ok4uw	560	10	these	these	DT
cord-001835-0s7ok4uw	560	11	predictions	prediction	NNS
cord-001835-0s7ok4uw	560	12	.	.	.
cord-001835-0s7ok4uw	561	1	Preliminary	preliminary	JJ
cord-001835-0s7ok4uw	561	2	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	561	3	results	result	NNS
cord-001835-0s7ok4uw	561	4	show	show	VBP
cord-001835-0s7ok4uw	561	5	that	that	IN
cord-001835-0s7ok4uw	561	6	one	one	CD
cord-001835-0s7ok4uw	561	7	SG	SG	NNP
cord-001835-0s7ok4uw	561	8	protein	protein	NN
cord-001835-0s7ok4uw	561	9	,	,	,
cord-001835-0s7ok4uw	561	10	Thermus	Thermus	NNP
cord-001835-0s7ok4uw	561	11	thermophilus	thermophilus	NNP
cord-001835-0s7ok4uw	562	1	Q5SLS5_THET8	Q5SLS5_THET8	NNP
cord-001835-0s7ok4uw	562	2	,	,	,
cord-001835-0s7ok4uw	562	3	classified	classify	VBN
cord-001835-0s7ok4uw	562	4	as	as	IN
cord-001835-0s7ok4uw	562	5	a	a	DT
cord-001835-0s7ok4uw	562	6	probable	probable	JJ
cord-001835-0s7ok4uw	562	7	enoyl	enoyl	JJ
cord-001835-0s7ok4uw	562	8	-	-	HYPH
cord-001835-0s7ok4uw	562	9	CoA	CoA	NNP
cord-001835-0s7ok4uw	562	10	hydratase	hydratase	NNP
cord-001835-0s7ok4uw	562	11	,	,	,
cord-001835-0s7ok4uw	562	12	possesses	possess	VBZ
cord-001835-0s7ok4uw	562	13	hydrolase	hydrolase	NN
cord-001835-0s7ok4uw	562	14	activity	activity	NN
cord-001835-0s7ok4uw	562	15	as	as	IN
cord-001835-0s7ok4uw	562	16	predicted	predict	VBN
cord-001835-0s7ok4uw	562	17	by	by	IN
cord-001835-0s7ok4uw	562	18	our	-PRON-	PRP$
cord-001835-0s7ok4uw	562	19	methods	method	NNS
cord-001835-0s7ok4uw	562	20	.	.	.
cord-001835-0s7ok4uw	563	1	The	the	DT
cord-001835-0s7ok4uw	563	2	outcomes	outcome	NNS
cord-001835-0s7ok4uw	563	3	of	of	IN
cord-001835-0s7ok4uw	563	4	this	this	DT
cord-001835-0s7ok4uw	563	5	project	project	NN
cord-001835-0s7ok4uw	563	6	will	will	MD
cord-001835-0s7ok4uw	563	7	be	be	VB
cord-001835-0s7ok4uw	563	8	to	to	TO
cord-001835-0s7ok4uw	563	9	successfully	successfully	RB
cord-001835-0s7ok4uw	563	10	classify	classify	VB
cord-001835-0s7ok4uw	563	11	the	the	DT
cord-001835-0s7ok4uw	563	12	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	563	13	functions	function	NNS
cord-001835-0s7ok4uw	563	14	of	of	IN
cord-001835-0s7ok4uw	563	15	SG	SG	NNP
cord-001835-0s7ok4uw	563	16	proteins	protein	NNS
cord-001835-0s7ok4uw	563	17	based	base	VBN
cord-001835-0s7ok4uw	563	18	on	on	IN
cord-001835-0s7ok4uw	563	19	their	-PRON-	PRP$
cord-001835-0s7ok4uw	563	20	local	local	JJ
cord-001835-0s7ok4uw	563	21	structure	structure	NN
cord-001835-0s7ok4uw	563	22	at	at	IN
cord-001835-0s7ok4uw	563	23	the	the	DT
cord-001835-0s7ok4uw	563	24	predicted	predict	VBN
cord-001835-0s7ok4uw	563	25	active	active	JJ
cord-001835-0s7ok4uw	563	26	sites	site	NNS
cord-001835-0s7ok4uw	563	27	and	and	CC
cord-001835-0s7ok4uw	563	28	to	to	TO
cord-001835-0s7ok4uw	563	29	provide	provide	VB
cord-001835-0s7ok4uw	563	30	a	a	DT
cord-001835-0s7ok4uw	563	31	conceptual	conceptual	JJ
cord-001835-0s7ok4uw	563	32	framework	framework	NN
cord-001835-0s7ok4uw	563	33	for	for	IN
cord-001835-0s7ok4uw	563	34	the	the	DT
cord-001835-0s7ok4uw	563	35	functional	functional	JJ
cord-001835-0s7ok4uw	563	36	classification	classification	NN
cord-001835-0s7ok4uw	563	37	of	of	IN
cord-001835-0s7ok4uw	563	38	the	the	DT
cord-001835-0s7ok4uw	563	39	remaining	remain	VBG
cord-001835-0s7ok4uw	563	40	SG	SG	NNP
cord-001835-0s7ok4uw	563	41	proteins	protein	NNS
cord-001835-0s7ok4uw	563	42	within	within	IN
cord-001835-0s7ok4uw	563	43	the	the	DT
cord-001835-0s7ok4uw	563	44	PDB	PDB	NNP
cord-001835-0s7ok4uw	563	45	.	.	.
cord-001835-0s7ok4uw	564	1	This	this	DT
cord-001835-0s7ok4uw	564	2	work	work	NN
cord-001835-0s7ok4uw	564	3	is	be	VBZ
cord-001835-0s7ok4uw	564	4	supported	support	VBN
cord-001835-0s7ok4uw	564	5	by	by	IN
cord-001835-0s7ok4uw	564	6	NSF	NSF	NNP
cord-001835-0s7ok4uw	564	7	-	-	HYPH
cord-001835-0s7ok4uw	564	8	CHE-1305655	CHE-1305655	NNP
cord-001835-0s7ok4uw	564	9	.	.	.
cord-001835-0s7ok4uw	565	1	Directly	directly	RB
cord-001835-0s7ok4uw	565	2	observing	observe	VBG
cord-001835-0s7ok4uw	565	3	the	the	DT
cord-001835-0s7ok4uw	565	4	synergistic	synergistic	JJ
cord-001835-0s7ok4uw	565	5	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	565	6	in	in	IN
cord-001835-0s7ok4uw	565	7	F	F	NNP
cord-001835-0s7ok4uw	565	8	-	-	HYPH
cord-001835-0s7ok4uw	565	9	actin	actin	NNP
cord-001835-0s7ok4uw	565	10	and	and	CC
cord-001835-0s7ok4uw	565	11	microtubule	microtubule	NN
cord-001835-0s7ok4uw	565	12	assembly	assembly	NN
cord-001835-0s7ok4uw	565	13	Jun	Jun	NNP
cord-001835-0s7ok4uw	565	14	Zhang	Zhang	NNP
cord-001835-0s7ok4uw	565	15	1	1	CD
cord-001835-0s7ok4uw	565	16	,	,	,
cord-001835-0s7ok4uw	565	17	Deqiang	Deqiang	NNP
cord-001835-0s7ok4uw	565	18	Wang	Wang	NNP
cord-001835-0s7ok4uw	565	19	2	2	CD
cord-001835-0s7ok4uw	565	20	1	1	CD
cord-001835-0s7ok4uw	566	1	The	the	DT
cord-001835-0s7ok4uw	566	2	Department	Department	NNP
cord-001835-0s7ok4uw	566	3	of	of	IN
cord-001835-0s7ok4uw	566	4	Cell	Cell	NNP
cord-001835-0s7ok4uw	566	5	Biology	Biology	NNP
cord-001835-0s7ok4uw	566	6	and	and	CC
cord-001835-0s7ok4uw	566	7	Genetics	Genetics	NNP
cord-001835-0s7ok4uw	566	8	,	,	,
cord-001835-0s7ok4uw	566	9	2	2	CD
cord-001835-0s7ok4uw	566	10	Key	Key	NNP
cord-001835-0s7ok4uw	566	11	Laboratory	Laboratory	NNP
cord-001835-0s7ok4uw	566	12	of	of	IN
cord-001835-0s7ok4uw	566	13	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	566	14	Biology	Biology	NNP
cord-001835-0s7ok4uw	566	15	on	on	IN
cord-001835-0s7ok4uw	566	16	Infectious	Infectious	NNP
cord-001835-0s7ok4uw	566	17	Disease	Disease	NNP
cord-001835-0s7ok4uw	567	1	Although	although	IN
cord-001835-0s7ok4uw	567	2	important	important	JJ
cord-001835-0s7ok4uw	567	3	in	in	IN
cord-001835-0s7ok4uw	567	4	cellular	cellular	JJ
cord-001835-0s7ok4uw	567	5	activities	activity	NNS
cord-001835-0s7ok4uw	567	6	,	,	,
cord-001835-0s7ok4uw	567	7	little	little	JJ
cord-001835-0s7ok4uw	567	8	attention	attention	NN
cord-001835-0s7ok4uw	567	9	was	be	VBD
cord-001835-0s7ok4uw	567	10	paid	pay	VBN
cord-001835-0s7ok4uw	567	11	to	to	IN
cord-001835-0s7ok4uw	567	12	the	the	DT
cord-001835-0s7ok4uw	567	13	synergistic	synergistic	JJ
cord-001835-0s7ok4uw	567	14	effects	effect	NNS
cord-001835-0s7ok4uw	567	15	of	of	IN
cord-001835-0s7ok4uw	567	16	actin	actin	NN
cord-001835-0s7ok4uw	567	17	and	and	CC
cord-001835-0s7ok4uw	567	18	microtubule	microtubule	NN
cord-001835-0s7ok4uw	567	19	cytoskeleton	cytoskeleton	NN
cord-001835-0s7ok4uw	567	20	assembly	assembly	NN
cord-001835-0s7ok4uw	567	21	.	.	.
cord-001835-0s7ok4uw	568	1	With	with	IN
cord-001835-0s7ok4uw	568	2	the	the	DT
cord-001835-0s7ok4uw	568	3	time	time	NN
cord-001835-0s7ok4uw	568	4	-	-	HYPH
cord-001835-0s7ok4uw	568	5	lapse	lapse	NN
cord-001835-0s7ok4uw	568	6	atomic	atomic	JJ
cord-001835-0s7ok4uw	568	7	force	force	NN
cord-001835-0s7ok4uw	568	8	microscope	microscope	NN
cord-001835-0s7ok4uw	568	9	(	(	-LRB-
cord-001835-0s7ok4uw	568	10	TL	TL	NNP
cord-001835-0s7ok4uw	568	11	-	-	HYPH
cord-001835-0s7ok4uw	568	12	AFM	AFM	NNP
cord-001835-0s7ok4uw	568	13	)	)	-RRB-
cord-001835-0s7ok4uw	568	14	,	,	,
cord-001835-0s7ok4uw	568	15	we	-PRON-	PRP
cord-001835-0s7ok4uw	568	16	directly	directly	RB
cord-001835-0s7ok4uw	568	17	observed	observe	VBD
cord-001835-0s7ok4uw	568	18	the	the	DT
cord-001835-0s7ok4uw	568	19	large	large	JJ
cord-001835-0s7ok4uw	568	20	-	-	HYPH
cord-001835-0s7ok4uw	568	21	scale	scale	NN
cord-001835-0s7ok4uw	568	22	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	568	23	structure	structure	NN
cord-001835-0s7ok4uw	568	24	of	of	IN
cord-001835-0s7ok4uw	568	25	actin	actin	NN
cord-001835-0s7ok4uw	568	26	filaments	filament	NNS
cord-001835-0s7ok4uw	568	27	formed	form	VBN
cord-001835-0s7ok4uw	568	28	in	in	IN
cord-001835-0s7ok4uw	568	29	the	the	DT
cord-001835-0s7ok4uw	568	30	presence	presence	NN
cord-001835-0s7ok4uw	568	31	or	or	CC
cord-001835-0s7ok4uw	568	32	absence	absence	NN
cord-001835-0s7ok4uw	568	33	of	of	IN
cord-001835-0s7ok4uw	568	34	microtubulin	microtubulin	NNP
cord-001835-0s7ok4uw	568	35	in	in	IN
cord-001835-0s7ok4uw	568	36	solution	solution	NN
cord-001835-0s7ok4uw	568	37	.	.	.
cord-001835-0s7ok4uw	569	1	In	in	IN
cord-001835-0s7ok4uw	569	2	absence	absence	NN
cord-001835-0s7ok4uw	569	3	of	of	IN
cord-001835-0s7ok4uw	569	4	microtubulin	microtubulin	NNP
cord-001835-0s7ok4uw	569	5	,	,	,
cord-001835-0s7ok4uw	569	6	the	the	DT
cord-001835-0s7ok4uw	569	7	G	g	NN
cord-001835-0s7ok4uw	569	8	-	-	HYPH
cord-001835-0s7ok4uw	569	9	actin	actin	NN
cord-001835-0s7ok4uw	569	10	could	could	MD
cord-001835-0s7ok4uw	569	11	be	be	VB
cord-001835-0s7ok4uw	569	12	polymerized	polymerize	VBN
cord-001835-0s7ok4uw	569	13	into	into	IN
cord-001835-0s7ok4uw	569	14	ordered	order	VBN
cord-001835-0s7ok4uw	569	15	filamentous	filamentous	JJ
cord-001835-0s7ok4uw	569	16	structures	structure	NNS
cord-001835-0s7ok4uw	569	17	with	with	IN
cord-001835-0s7ok4uw	569	18	different	different	JJ
cord-001835-0s7ok4uw	569	19	diameter	diameter	NN
cord-001835-0s7ok4uw	569	20	from	from	IN
cord-001835-0s7ok4uw	569	21	the	the	DT
cord-001835-0s7ok4uw	569	22	slimmest	slim	JJS
cord-001835-0s7ok4uw	569	23	filament	filament	NN
cord-001835-0s7ok4uw	569	24	of	of	IN
cord-001835-0s7ok4uw	569	25	single	single	JJ
cord-001835-0s7ok4uw	569	26	F	F	NNP
cord-001835-0s7ok4uw	569	27	-	-	HYPH
cord-001835-0s7ok4uw	569	28	actin	actin	NNP
cord-001835-0s7ok4uw	569	29	to	to	IN
cord-001835-0s7ok4uw	569	30	giant	giant	JJ
cord-001835-0s7ok4uw	569	31	filament	filament	NN
cord-001835-0s7ok4uw	569	32	in	in	IN
cord-001835-0s7ok4uw	569	33	tree	tree	NN
cord-001835-0s7ok4uw	569	34	-	-	HYPH
cord-001835-0s7ok4uw	569	35	like	like	JJ
cord-001835-0s7ok4uw	569	36	branched	branched	JJ
cord-001835-0s7ok4uw	569	37	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	569	38	.	.	.
cord-001835-0s7ok4uw	570	1	The	the	DT
cord-001835-0s7ok4uw	570	2	polymerized	polymerized	JJ
cord-001835-0s7ok4uw	570	3	actin	actin	NN
cord-001835-0s7ok4uw	570	4	filaments	filament	NNS
cord-001835-0s7ok4uw	570	5	,	,	,
cord-001835-0s7ok4uw	570	6	to	to	TO
cord-001835-0s7ok4uw	570	7	which	which	WDT
cord-001835-0s7ok4uw	570	8	our	-PRON-	PRP$
cord-001835-0s7ok4uw	570	9	most	most	RBS
cord-001835-0s7ok4uw	570	10	intense	intense	JJ
cord-001835-0s7ok4uw	570	11	attention	attention	NN
cord-001835-0s7ok4uw	570	12	was	be	VBD
cord-001835-0s7ok4uw	570	13	attracted	attract	VBN
cord-001835-0s7ok4uw	570	14	,	,	,
cord-001835-0s7ok4uw	570	15	was	be	VBD
cord-001835-0s7ok4uw	570	16	discretely	discretely	RB
cord-001835-0s7ok4uw	570	17	arranged	arrange	VBN
cord-001835-0s7ok4uw	570	18	and	and	CC
cord-001835-0s7ok4uw	570	19	showed	show	VBD
cord-001835-0s7ok4uw	570	20	obvious	obvious	JJ
cord-001835-0s7ok4uw	570	21	polymorphism	polymorphism	NN
cord-001835-0s7ok4uw	570	22	in	in	IN
cord-001835-0s7ok4uw	570	23	structures	structure	NNS
cord-001835-0s7ok4uw	570	24	completely	completely	RB
cord-001835-0s7ok4uw	570	25	distinct	distinct	JJ
cord-001835-0s7ok4uw	570	26	from	from	IN
cord-001835-0s7ok4uw	570	27	those	those	DT
cord-001835-0s7ok4uw	570	28	in	in	IN
cord-001835-0s7ok4uw	570	29	the	the	DT
cord-001835-0s7ok4uw	570	30	presence	presence	NN
cord-001835-0s7ok4uw	570	31	of	of	IN
cord-001835-0s7ok4uw	570	32	microtubulin	microtubulin	NNP
cord-001835-0s7ok4uw	570	33	.	.	.
cord-001835-0s7ok4uw	571	1	The	the	DT
cord-001835-0s7ok4uw	571	2	supra	supra	JJ
cord-001835-0s7ok4uw	571	3	-	-	HYPH
cord-001835-0s7ok4uw	571	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	571	5	complex	complex	JJ
cord-001835-0s7ok4uw	571	6	structures	structure	NNS
cord-001835-0s7ok4uw	571	7	of	of	IN
cord-001835-0s7ok4uw	571	8	the	the	DT
cord-001835-0s7ok4uw	571	9	latter	latter	JJ
cord-001835-0s7ok4uw	571	10	were	be	VBD
cord-001835-0s7ok4uw	571	11	mainly	mainly	RB
cord-001835-0s7ok4uw	571	12	composed	compose	VBN
cord-001835-0s7ok4uw	571	13	of	of	IN
cord-001835-0s7ok4uw	571	14	single	single	JJ
cord-001835-0s7ok4uw	571	15	F	F	NNP
cord-001835-0s7ok4uw	571	16	-	-	HYPH
cord-001835-0s7ok4uw	571	17	actin	actin	NNP
cord-001835-0s7ok4uw	571	18	and/or	and/or	CC
cord-001835-0s7ok4uw	571	19	multifilaments	multifilament	NNS
cord-001835-0s7ok4uw	571	20	clearly	clearly	RB
cord-001835-0s7ok4uw	571	21	consisting	consist	VBG
cord-001835-0s7ok4uw	571	22	of	of	IN
cord-001835-0s7ok4uw	571	23	several	several	JJ
cord-001835-0s7ok4uw	571	24	single	single	JJ
cord-001835-0s7ok4uw	571	25	F	f	NN
cord-001835-0s7ok4uw	571	26	-	-	HYPH
cord-001835-0s7ok4uw	571	27	actin	actin	NNP
cord-001835-0s7ok4uw	571	28	and	and	CC
cord-001835-0s7ok4uw	571	29	regularly	regularly	RB
cord-001835-0s7ok4uw	571	30	cross	cross	VB
cord-001835-0s7ok4uw	571	31	-	-	VBN
cord-001835-0s7ok4uw	571	32	linked	link	VBN
cord-001835-0s7ok4uw	571	33	with	with	IN
cord-001835-0s7ok4uw	571	34	the	the	DT
cord-001835-0s7ok4uw	571	35	assembled	assemble	VBN
cord-001835-0s7ok4uw	571	36	microtubular	microtubular	JJ
cord-001835-0s7ok4uw	571	37	bundles	bundle	NNS
cord-001835-0s7ok4uw	571	38	.	.	.
cord-001835-0s7ok4uw	572	1	The	the	DT
cord-001835-0s7ok4uw	572	2	experimental	experimental	JJ
cord-001835-0s7ok4uw	572	3	results	result	NNS
cord-001835-0s7ok4uw	572	4	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	572	5	that	that	IN
cord-001835-0s7ok4uw	572	6	the	the	DT
cord-001835-0s7ok4uw	572	7	F	F	NNP
cord-001835-0s7ok4uw	572	8	-	-	HYPH
cord-001835-0s7ok4uw	572	9	actin	actin	NN
cord-001835-0s7ok4uw	572	10	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	572	11	could	could	MD
cord-001835-0s7ok4uw	572	12	be	be	VB
cord-001835-0s7ok4uw	572	13	coordinated	coordinate	VBN
cord-001835-0s7ok4uw	572	14	by	by	IN
cord-001835-0s7ok4uw	572	15	microtubule	microtubule	NNP
cord-001835-0s7ok4uw	572	16	assembly	assembly	NNP
cord-001835-0s7ok4uw	572	17	.	.	.
cord-001835-0s7ok4uw	573	1	Further	further	JJ
cord-001835-0s7ok4uw	573	2	analyses	analysis	NNS
cord-001835-0s7ok4uw	573	3	implied	imply	VBD
cord-001835-0s7ok4uw	573	4	that	that	IN
cord-001835-0s7ok4uw	573	5	the	the	DT
cord-001835-0s7ok4uw	573	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	573	7	between	between	IN
cord-001835-0s7ok4uw	573	8	F	F	NNP
cord-001835-0s7ok4uw	573	9	-	-	HYPH
cord-001835-0s7ok4uw	573	10	actin	actin	NN
cord-001835-0s7ok4uw	573	11	and	and	CC
cord-001835-0s7ok4uw	573	12	microtubule	microtubule	NN
cord-001835-0s7ok4uw	573	13	could	could	MD
cord-001835-0s7ok4uw	573	14	prevent	prevent	VB
cord-001835-0s7ok4uw	573	15	the	the	DT
cord-001835-0s7ok4uw	573	16	emergence	emergence	NN
cord-001835-0s7ok4uw	573	17	of	of	IN
cord-001835-0s7ok4uw	573	18	structural	structural	JJ
cord-001835-0s7ok4uw	573	19	polymorphism	polymorphism	NN
cord-001835-0s7ok4uw	573	20	of	of	IN
cord-001835-0s7ok4uw	573	21	F	F	NNP
cord-001835-0s7ok4uw	573	22	-	-	HYPH
cord-001835-0s7ok4uw	573	23	actin	actin	NNP
cord-001835-0s7ok4uw	573	24	alone	alone	RB
cord-001835-0s7ok4uw	573	25	,	,	,
cord-001835-0s7ok4uw	573	26	and	and	CC
cord-001835-0s7ok4uw	573	27	give	give	VB
cord-001835-0s7ok4uw	573	28	rise	rise	NN
cord-001835-0s7ok4uw	573	29	to	to	IN
cord-001835-0s7ok4uw	573	30	organization	organization	NN
cord-001835-0s7ok4uw	573	31	of	of	IN
cord-001835-0s7ok4uw	573	32	specific	specific	JJ
cord-001835-0s7ok4uw	573	33	complex	complex	JJ
cord-001835-0s7ok4uw	573	34	structures	structure	NNS
cord-001835-0s7ok4uw	573	35	instead	instead	RB
cord-001835-0s7ok4uw	573	36	.	.	.
cord-001835-0s7ok4uw	574	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	574	2	was	be	VBD
cord-001835-0s7ok4uw	574	3	suggested	suggest	VBN
cord-001835-0s7ok4uw	574	4	that	that	IN
cord-001835-0s7ok4uw	574	5	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	574	6	synergy	synergy	NN
cord-001835-0s7ok4uw	574	7	between	between	IN
cord-001835-0s7ok4uw	574	8	the	the	DT
cord-001835-0s7ok4uw	574	9	F	F	NNP
cord-001835-0s7ok4uw	574	10	-	-	HYPH
cord-001835-0s7ok4uw	574	11	actin	actin	NNP
cord-001835-0s7ok4uw	574	12	and	and	CC
cord-001835-0s7ok4uw	574	13	microtubule	microtubule	NN
cord-001835-0s7ok4uw	574	14	would	would	MD
cord-001835-0s7ok4uw	574	15	be	be	VB
cord-001835-0s7ok4uw	574	16	implicated	implicate	VBN
cord-001835-0s7ok4uw	574	17	in	in	IN
cord-001835-0s7ok4uw	574	18	living	live	VBG
cord-001835-0s7ok4uw	574	19	cells	cell	NNS
cord-001835-0s7ok4uw	574	20	.	.	.
cord-001835-0s7ok4uw	575	1	The	the	DT
cord-001835-0s7ok4uw	575	2	adaptor	adaptor	NN
cord-001835-0s7ok4uw	575	3	protein	protein	NN
cord-001835-0s7ok4uw	575	4	14	14	CD
cord-001835-0s7ok4uw	575	5	-	-	SYM
cord-001835-0s7ok4uw	575	6	3	3	CD
cord-001835-0s7ok4uw	575	7	-	-	SYM
cord-001835-0s7ok4uw	575	8	3	3	CD
cord-001835-0s7ok4uw	575	9	is	be	VBZ
cord-001835-0s7ok4uw	575	10	found	find	VBN
cord-001835-0s7ok4uw	575	11	in	in	IN
cord-001835-0s7ok4uw	575	12	a	a	DT
cord-001835-0s7ok4uw	575	13	diverse	diverse	JJ
cord-001835-0s7ok4uw	575	14	range	range	NN
cord-001835-0s7ok4uw	575	15	of	of	IN
cord-001835-0s7ok4uw	575	16	pathologically	pathologically	RB
cord-001835-0s7ok4uw	575	17	relevant	relevant	JJ
cord-001835-0s7ok4uw	575	18	protein	protein	NN
cord-001835-0s7ok4uw	575	19	-	-	HYPH
cord-001835-0s7ok4uw	575	20	protein	protein	NN
cord-001835-0s7ok4uw	575	21	interactions	interaction	NNS
cord-001835-0s7ok4uw	575	22	(	(	-LRB-
cord-001835-0s7ok4uw	575	23	PPIs	ppi	NNS
cord-001835-0s7ok4uw	575	24	)	)	-RRB-
cord-001835-0s7ok4uw	575	25	.	.	.
cord-001835-0s7ok4uw	576	1	As	as	IN
cord-001835-0s7ok4uw	576	2	14	14	CD
cord-001835-0s7ok4uw	576	3	-	-	SYM
cord-001835-0s7ok4uw	576	4	3	3	CD
cord-001835-0s7ok4uw	576	5	-	-	SYM
cord-001835-0s7ok4uw	576	6	3	3	CD
cord-001835-0s7ok4uw	576	7	is	be	VBZ
cord-001835-0s7ok4uw	576	8	a	a	DT
cord-001835-0s7ok4uw	576	9	hub	hub	NN
cord-001835-0s7ok4uw	576	10	protein	protein	NN
cord-001835-0s7ok4uw	576	11	with	with	IN
cord-001835-0s7ok4uw	576	12	very	very	RB
cord-001835-0s7ok4uw	576	13	diverse	diverse	JJ
cord-001835-0s7ok4uw	576	14	interactions	interaction	NNS
cord-001835-0s7ok4uw	576	15	,	,	,
cord-001835-0s7ok4uw	576	16	it	-PRON-	PRP
cord-001835-0s7ok4uw	576	17	is	be	VBZ
cord-001835-0s7ok4uw	576	18	able	able	JJ
cord-001835-0s7ok4uw	576	19	to	to	TO
cord-001835-0s7ok4uw	576	20	influence	influence	VB
cord-001835-0s7ok4uw	576	21	the	the	DT
cord-001835-0s7ok4uw	576	22	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	576	23	localization	localization	NN
cord-001835-0s7ok4uw	576	24	of	of	IN
cord-001835-0s7ok4uw	576	25	their	-PRON-	PRP$
cord-001835-0s7ok4uw	576	26	binding	bind	VBG
cord-001835-0s7ok4uw	576	27	partners	partner	NNS
cord-001835-0s7ok4uw	576	28	and	and	CC
cord-001835-0s7ok4uw	576	29	they	-PRON-	PRP
cord-001835-0s7ok4uw	576	30	are	be	VBP
cord-001835-0s7ok4uw	576	31	key	key	JJ
cord-001835-0s7ok4uw	576	32	regulators	regulator	NNS
cord-001835-0s7ok4uw	576	33	of	of	IN
cord-001835-0s7ok4uw	576	34	signal	signal	NN
cord-001835-0s7ok4uw	576	35	transduction	transduction	NN
cord-001835-0s7ok4uw	576	36	processes	process	NNS
cord-001835-0s7ok4uw	576	37	as	as	RB
cord-001835-0s7ok4uw	576	38	well	well	RB
cord-001835-0s7ok4uw	576	39	as	as	IN
cord-001835-0s7ok4uw	576	40	regulators	regulator	NNS
cord-001835-0s7ok4uw	576	41	of	of	IN
cord-001835-0s7ok4uw	576	42	cell	cell	NN
cord-001835-0s7ok4uw	576	43	cycle	cycle	NN
cord-001835-0s7ok4uw	576	44	functions	function	NNS
cord-001835-0s7ok4uw	576	45	.	.	.
cord-001835-0s7ok4uw	577	1	Nevertheless	nevertheless	RB
cord-001835-0s7ok4uw	577	2	,	,	,
cord-001835-0s7ok4uw	577	3	there	there	EX
cord-001835-0s7ok4uw	577	4	are	be	VBP
cord-001835-0s7ok4uw	577	5	only	only	RB
cord-001835-0s7ok4uw	577	6	few	few	JJ
cord-001835-0s7ok4uw	577	7	examples	example	NNS
cord-001835-0s7ok4uw	577	8	of	of	IN
cord-001835-0s7ok4uw	577	9	14	14	CD
cord-001835-0s7ok4uw	577	10	-	-	SYM
cord-001835-0s7ok4uw	577	11	3	3	CD
cord-001835-0s7ok4uw	577	12	-	-	SYM
cord-001835-0s7ok4uw	577	13	3	3	CD
cord-001835-0s7ok4uw	577	14	acting	acting	NN
cord-001835-0s7ok4uw	577	15	extracellularly	extracellularly	RB
cord-001835-0s7ok4uw	577	16	.	.	.
cord-001835-0s7ok4uw	578	1	One	one	CD
cord-001835-0s7ok4uw	578	2	of	of	IN
cord-001835-0s7ok4uw	578	3	the	the	DT
cord-001835-0s7ok4uw	578	4	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	578	5	targets	target	NNS
cord-001835-0s7ok4uw	578	6	for	for	IN
cord-001835-0s7ok4uw	578	7	14	14	CD
cord-001835-0s7ok4uw	578	8	-	-	SYM
cord-001835-0s7ok4uw	578	9	3	3	CD
cord-001835-0s7ok4uw	578	10	-	-	SYM
cord-001835-0s7ok4uw	578	11	3	3	CD
cord-001835-0s7ok4uw	578	12	is	be	VBZ
cord-001835-0s7ok4uw	578	13	Aminopeptidase	Aminopeptidase	NNP
cord-001835-0s7ok4uw	578	14	N	N	NNP
cord-001835-0s7ok4uw	578	15	(	(	-LRB-
cord-001835-0s7ok4uw	578	16	APN	APN	NNP
cord-001835-0s7ok4uw	578	17	)	)	-RRB-
cord-001835-0s7ok4uw	578	18	.	.	.
cord-001835-0s7ok4uw	579	1	APN	APN	NNP
cord-001835-0s7ok4uw	579	2	is	be	VBZ
cord-001835-0s7ok4uw	579	3	an	an	DT
cord-001835-0s7ok4uw	579	4	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	579	5	trans	trans	NN
cord-001835-0s7ok4uw	579	6	-	-	NN
cord-001835-0s7ok4uw	579	7	membrane	membrane	NN
cord-001835-0s7ok4uw	579	8	enzyme	enzyme	NN
cord-001835-0s7ok4uw	579	9	that	that	WDT
cord-001835-0s7ok4uw	579	10	acts	act	VBZ
cord-001835-0s7ok4uw	579	11	as	as	IN
cord-001835-0s7ok4uw	579	12	a	a	DT
cord-001835-0s7ok4uw	579	13	receptor	receptor	NN
cord-001835-0s7ok4uw	579	14	for	for	IN
cord-001835-0s7ok4uw	579	15	14	14	CD
cord-001835-0s7ok4uw	579	16	-	-	SYM
cord-001835-0s7ok4uw	579	17	3	3	CD
cord-001835-0s7ok4uw	579	18	-	-	SYM
cord-001835-0s7ok4uw	579	19	3	3	CD
cord-001835-0s7ok4uw	579	20	.	.	.
cord-001835-0s7ok4uw	580	1	Binding	bind	VBG
cord-001835-0s7ok4uw	580	2	to	to	IN
cord-001835-0s7ok4uw	580	3	APN	APN	NNP
cord-001835-0s7ok4uw	580	4	,	,	,
cord-001835-0s7ok4uw	580	5	14	14	CD
cord-001835-0s7ok4uw	580	6	-	-	SYM
cord-001835-0s7ok4uw	580	7	3	3	CD
cord-001835-0s7ok4uw	580	8	-	-	SYM
cord-001835-0s7ok4uw	580	9	3	3	CD
cord-001835-0s7ok4uw	580	10	excreted	excrete	VBN
cord-001835-0s7ok4uw	580	11	by	by	IN
cord-001835-0s7ok4uw	580	12	keratinocytes	keratinocyte	NNS
cord-001835-0s7ok4uw	580	13	can	can	MD
cord-001835-0s7ok4uw	580	14	upregulate	upregulate	VB
cord-001835-0s7ok4uw	580	15	the	the	DT
cord-001835-0s7ok4uw	580	16	excretion	excretion	NN
cord-001835-0s7ok4uw	580	17	of	of	IN
cord-001835-0s7ok4uw	580	18	matrix	matrix	NN
cord-001835-0s7ok4uw	580	19	metalloproteinase-1	metalloproteinase-1	NNP
cord-001835-0s7ok4uw	580	20	(	(	-LRB-
cord-001835-0s7ok4uw	580	21	MMP1	MMP1	NNP
cord-001835-0s7ok4uw	580	22	)	)	-RRB-
cord-001835-0s7ok4uw	580	23	in	in	IN
cord-001835-0s7ok4uw	580	24	fibroblasts	fibroblast	NNS
cord-001835-0s7ok4uw	580	25	.	.	.
cord-001835-0s7ok4uw	581	1	MMP1	MMP1	NNP
cord-001835-0s7ok4uw	581	2	,	,	,
cord-001835-0s7ok4uw	581	3	by	by	IN
cord-001835-0s7ok4uw	581	4	breaking	break	VBG
cord-001835-0s7ok4uw	581	5	down	down	RP
cord-001835-0s7ok4uw	581	6	collagens	collagen	NNS
cord-001835-0s7ok4uw	581	7	,	,	,
cord-001835-0s7ok4uw	581	8	is	be	VBZ
cord-001835-0s7ok4uw	581	9	key	key	JJ
cord-001835-0s7ok4uw	581	10	in	in	IN
cord-001835-0s7ok4uw	581	11	the	the	DT
cord-001835-0s7ok4uw	581	12	remodeling	remodeling	NN
cord-001835-0s7ok4uw	581	13	of	of	IN
cord-001835-0s7ok4uw	581	14	the	the	DT
cord-001835-0s7ok4uw	581	15	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	581	16	matrix	matrix	NN
cord-001835-0s7ok4uw	581	17	.	.	.
cord-001835-0s7ok4uw	582	1	Modulation	modulation	NN
cord-001835-0s7ok4uw	582	2	of	of	IN
cord-001835-0s7ok4uw	582	3	the	the	DT
cord-001835-0s7ok4uw	582	4	14	14	CD
cord-001835-0s7ok4uw	582	5	-	-	SYM
cord-001835-0s7ok4uw	582	6	3	3	CD
cord-001835-0s7ok4uw	582	7	-	-	SYM
cord-001835-0s7ok4uw	582	8	3	3	CD
cord-001835-0s7ok4uw	582	9	/	/	SYM
cord-001835-0s7ok4uw	582	10	APN	APN	NNP
cord-001835-0s7ok4uw	582	11	interaction	interaction	NN
cord-001835-0s7ok4uw	582	12	thereby	thereby	RB
cord-001835-0s7ok4uw	582	13	may	may	MD
cord-001835-0s7ok4uw	582	14	play	play	VB
cord-001835-0s7ok4uw	582	15	a	a	DT
cord-001835-0s7ok4uw	582	16	crucial	crucial	JJ
cord-001835-0s7ok4uw	582	17	role	role	NN
cord-001835-0s7ok4uw	582	18	in	in	IN
cord-001835-0s7ok4uw	582	19	the	the	DT
cord-001835-0s7ok4uw	582	20	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	582	21	understanding	understanding	NN
cord-001835-0s7ok4uw	582	22	and	and	CC
cord-001835-0s7ok4uw	582	23	ultimately	ultimately	RB
cord-001835-0s7ok4uw	582	24	treatment	treatment	NN
cord-001835-0s7ok4uw	582	25	of	of	IN
cord-001835-0s7ok4uw	582	26	wound	wound	NN
cord-001835-0s7ok4uw	582	27	healing	healing	NN
cord-001835-0s7ok4uw	582	28	,	,	,
cord-001835-0s7ok4uw	582	29	respiratory	respiratory	JJ
cord-001835-0s7ok4uw	582	30	diseases	disease	NNS
cord-001835-0s7ok4uw	582	31	and	and	CC
cord-001835-0s7ok4uw	582	32	tumor	tumor	NN
cord-001835-0s7ok4uw	582	33	growth	growth	NN
cord-001835-0s7ok4uw	582	34	.	.	.
cord-001835-0s7ok4uw	583	1	In	in	IN
cord-001835-0s7ok4uw	583	2	the	the	DT
cord-001835-0s7ok4uw	583	3	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	583	4	cell	cell	NN
cord-001835-0s7ok4uw	583	5	,	,	,
cord-001835-0s7ok4uw	583	6	the	the	DT
cord-001835-0s7ok4uw	583	7	14	14	CD
cord-001835-0s7ok4uw	583	8	-	-	SYM
cord-001835-0s7ok4uw	583	9	3	3	CD
cord-001835-0s7ok4uw	583	10	-	-	SYM
cord-001835-0s7ok4uw	583	11	3	3	CD
cord-001835-0s7ok4uw	583	12	dimer	dimer	NN
cord-001835-0s7ok4uw	583	13	operates	operate	VBZ
cord-001835-0s7ok4uw	583	14	as	as	IN
cord-001835-0s7ok4uw	583	15	an	an	DT
cord-001835-0s7ok4uw	583	16	adapter	adapter	NN
cord-001835-0s7ok4uw	583	17	platform	platform	NN
cord-001835-0s7ok4uw	583	18	for	for	IN
cord-001835-0s7ok4uw	583	19	binding	bind	VBG
cord-001835-0s7ok4uw	583	20	partners	partner	NNS
cord-001835-0s7ok4uw	583	21	.	.	.
cord-001835-0s7ok4uw	584	1	A	a	DT
cord-001835-0s7ok4uw	584	2	wide	wide	JJ
cord-001835-0s7ok4uw	584	3	range	range	NN
cord-001835-0s7ok4uw	584	4	of	of	IN
cord-001835-0s7ok4uw	584	5	classes	class	NNS
cord-001835-0s7ok4uw	584	6	of	of	IN
cord-001835-0s7ok4uw	584	7	(	(	-LRB-
cord-001835-0s7ok4uw	584	8	small	small	JJ
cord-001835-0s7ok4uw	584	9	)	)	-RRB-
cord-001835-0s7ok4uw	584	10	molecules	molecule	NNS
cord-001835-0s7ok4uw	584	11	,	,	,
cord-001835-0s7ok4uw	584	12	natural	natural	JJ
cord-001835-0s7ok4uw	584	13	products	product	NNS
cord-001835-0s7ok4uw	584	14	and	and	CC
cord-001835-0s7ok4uw	584	15	peptides	peptide	NNS
cord-001835-0s7ok4uw	584	16	has	have	VBZ
cord-001835-0s7ok4uw	584	17	been	be	VBN
cord-001835-0s7ok4uw	584	18	used	use	VBN
cord-001835-0s7ok4uw	584	19	to	to	TO
cord-001835-0s7ok4uw	584	20	modulate	modulate	VB
cord-001835-0s7ok4uw	584	21	the	the	DT
cord-001835-0s7ok4uw	584	22	PPIs	ppi	NNS
cord-001835-0s7ok4uw	584	23	,	,	,
cord-001835-0s7ok4uw	584	24	providing	provide	VBG
cord-001835-0s7ok4uw	584	25	either	either	CC
cord-001835-0s7ok4uw	584	26	stabilization	stabilization	NN
cord-001835-0s7ok4uw	584	27	or	or	CC
cord-001835-0s7ok4uw	584	28	inhibition	inhibition	NN
cord-001835-0s7ok4uw	584	29	of	of	IN
cord-001835-0s7ok4uw	584	30	the	the	DT
cord-001835-0s7ok4uw	584	31	interactions	interaction	NNS
cord-001835-0s7ok4uw	584	32	of	of	IN
cord-001835-0s7ok4uw	584	33	14	14	CD
cord-001835-0s7ok4uw	584	34	-	-	SYM
cord-001835-0s7ok4uw	584	35	3	3	CD
cord-001835-0s7ok4uw	584	36	-	-	SYM
cord-001835-0s7ok4uw	584	37	3	3	CD
cord-001835-0s7ok4uw	584	38	with	with	IN
cord-001835-0s7ok4uw	584	39	its	-PRON-	PRP$
cord-001835-0s7ok4uw	584	40	binding	bind	VBG
cord-001835-0s7ok4uw	584	41	partner	partner	NN
cord-001835-0s7ok4uw	584	42	.	.	.
cord-001835-0s7ok4uw	585	1	Binding	bind	VBG
cord-001835-0s7ok4uw	585	2	partner	partner	NN
cord-001835-0s7ok4uw	585	3	fragments	fragment	NNS
cord-001835-0s7ok4uw	585	4	or	or	CC
cord-001835-0s7ok4uw	585	5	peptides	peptide	NNS
cord-001835-0s7ok4uw	585	6	are	be	VBP
cord-001835-0s7ok4uw	585	7	known	know	VBN
cord-001835-0s7ok4uw	585	8	to	to	TO
cord-001835-0s7ok4uw	585	9	bind	bind	VB
cord-001835-0s7ok4uw	585	10	to	to	IN
cord-001835-0s7ok4uw	585	11	the	the	DT
cord-001835-0s7ok4uw	585	12	14	14	CD
cord-001835-0s7ok4uw	585	13	-	-	SYM
cord-001835-0s7ok4uw	585	14	3	3	CD
cord-001835-0s7ok4uw	585	15	-	-	SYM
cord-001835-0s7ok4uw	585	16	3	3	CD
cord-001835-0s7ok4uw	585	17	binding	binding	NN
cord-001835-0s7ok4uw	585	18	groove	groove	NN
cord-001835-0s7ok4uw	585	19	via	via	IN
cord-001835-0s7ok4uw	585	20	arecognition	arecognition	NN
cord-001835-0s7ok4uw	585	21	motif	motif	NN
cord-001835-0s7ok4uw	585	22	containing	contain	VBG
cord-001835-0s7ok4uw	585	23	a	a	DT
cord-001835-0s7ok4uw	585	24	phosphorylated	phosphorylated	JJ
cord-001835-0s7ok4uw	585	25	serine	serine	NN
cord-001835-0s7ok4uw	585	26	or	or	CC
cord-001835-0s7ok4uw	585	27	threonine	threonine	NN
cord-001835-0s7ok4uw	585	28	.	.	.
cord-001835-0s7ok4uw	586	1	Making	make	VBG
cord-001835-0s7ok4uw	586	2	use	use	NN
cord-001835-0s7ok4uw	586	3	of	of	IN
cord-001835-0s7ok4uw	586	4	the	the	DT
cord-001835-0s7ok4uw	586	5	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	586	6	structure	structure	NN
cord-001835-0s7ok4uw	586	7	of	of	IN
cord-001835-0s7ok4uw	586	8	14	14	CD
cord-001835-0s7ok4uw	586	9	-	-	SYM
cord-001835-0s7ok4uw	586	10	3	3	CD
cord-001835-0s7ok4uw	586	11	-	-	SYM
cord-001835-0s7ok4uw	586	12	3	3	CD
cord-001835-0s7ok4uw	586	13	,	,	,
cord-001835-0s7ok4uw	586	14	novel	novel	JJ
cord-001835-0s7ok4uw	586	15	small	small	JJ
cord-001835-0s7ok4uw	586	16	-	-	HYPH
cord-001835-0s7ok4uw	586	17	molecule	molecule	NN
cord-001835-0s7ok4uw	586	18	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	586	19	may	may	MD
cord-001835-0s7ok4uw	586	20	be	be	VB
cord-001835-0s7ok4uw	586	21	tethered	tether	VBN
cord-001835-0s7ok4uw	586	22	to	to	TO
cord-001835-0s7ok4uw	586	23	exploit	exploit	VB
cord-001835-0s7ok4uw	586	24	the	the	DT
cord-001835-0s7ok4uw	586	25	bivalent	bivalent	JJ
cord-001835-0s7ok4uw	586	26	effect	effect	NN
cord-001835-0s7ok4uw	586	27	.	.	.
cord-001835-0s7ok4uw	587	1	From	from	IN
cord-001835-0s7ok4uw	587	2	a	a	DT
cord-001835-0s7ok4uw	587	3	large	large	JJ
cord-001835-0s7ok4uw	587	4	virtual	virtual	JJ
cord-001835-0s7ok4uw	587	5	screening	screening	NN
cord-001835-0s7ok4uw	587	6	and	and	CC
cord-001835-0s7ok4uw	587	7	experimental	experimental	JJ
cord-001835-0s7ok4uw	587	8	validation	validation	NN
cord-001835-0s7ok4uw	587	9	,	,	,
cord-001835-0s7ok4uw	587	10	a	a	DT
cord-001835-0s7ok4uw	587	11	scaffold	scaffold	NN
cord-001835-0s7ok4uw	587	12	containing	contain	VBG
cord-001835-0s7ok4uw	587	13	a	a	DT
cord-001835-0s7ok4uw	587	14	phenyl	phenyl	NN
cord-001835-0s7ok4uw	587	15	phosphonic	phosphonic	NNP
cord-001835-0s7ok4uw	587	16	moiety	moiety	NN
cord-001835-0s7ok4uw	587	17	was	be	VBD
cord-001835-0s7ok4uw	587	18	identified	identify	VBN
cord-001835-0s7ok4uw	587	19	,	,	,
cord-001835-0s7ok4uw	587	20	showing	show	VBG
cord-001835-0s7ok4uw	587	21	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	587	22	properties	property	NNS
cord-001835-0s7ok4uw	587	23	for	for	IN
cord-001835-0s7ok4uw	587	24	14	14	CD
cord-001835-0s7ok4uw	587	25	-	-	SYM
cord-001835-0s7ok4uw	587	26	3	3	CD
cord-001835-0s7ok4uw	587	27	-	-	SYM
cord-001835-0s7ok4uw	587	28	3	3	CD
cord-001835-0s7ok4uw	587	29	PPIs	ppi	NNS
cord-001835-0s7ok4uw	587	30	.	.	.
cord-001835-0s7ok4uw	588	1	Potent	potent	JJ
cord-001835-0s7ok4uw	588	2	derivatives	derivative	NNS
cord-001835-0s7ok4uw	588	3	of	of	IN
cord-001835-0s7ok4uw	588	4	this	this	DT
cord-001835-0s7ok4uw	588	5	scaffold	scaffold	NN
cord-001835-0s7ok4uw	588	6	were	be	VBD
cord-001835-0s7ok4uw	588	7	bridged	bridge	VBN
cord-001835-0s7ok4uw	588	8	by	by	IN
cord-001835-0s7ok4uw	588	9	polyethylene	polyethylene	NN
cord-001835-0s7ok4uw	588	10	glycol	glycol	NN
cord-001835-0s7ok4uw	588	11	(	(	-LRB-
cord-001835-0s7ok4uw	588	12	PEG	peg	NN
cord-001835-0s7ok4uw	588	13	)	)	-RRB-
cord-001835-0s7ok4uw	588	14	linkers	linker	NNS
cord-001835-0s7ok4uw	588	15	of	of	IN
cord-001835-0s7ok4uw	588	16	varying	vary	VBG
cord-001835-0s7ok4uw	588	17	lengths	length	NNS
cord-001835-0s7ok4uw	588	18	,	,	,
cord-001835-0s7ok4uw	588	19	thereby	thereby	RB
cord-001835-0s7ok4uw	588	20	facilitating	facilitate	VBG
cord-001835-0s7ok4uw	588	21	the	the	DT
cord-001835-0s7ok4uw	588	22	compound	compound	NN
cord-001835-0s7ok4uw	588	23	to	to	TO
cord-001835-0s7ok4uw	588	24	reach	reach	VB
cord-001835-0s7ok4uw	588	25	both	both	DT
cord-001835-0s7ok4uw	588	26	binding	bind	VBG
cord-001835-0s7ok4uw	588	27	sites	site	NNS
cord-001835-0s7ok4uw	588	28	of	of	IN
cord-001835-0s7ok4uw	588	29	the	the	DT
cord-001835-0s7ok4uw	588	30	14	14	CD
cord-001835-0s7ok4uw	588	31	-	-	SYM
cord-001835-0s7ok4uw	588	32	3	3	CD
cord-001835-0s7ok4uw	588	33	-	-	SYM
cord-001835-0s7ok4uw	588	34	3	3	CD
cord-001835-0s7ok4uw	588	35	dimer	dimer	NN
cord-001835-0s7ok4uw	588	36	and	and	CC
cord-001835-0s7ok4uw	588	37	concurrently	concurrently	RB
cord-001835-0s7ok4uw	588	38	increasing	increase	VBG
cord-001835-0s7ok4uw	588	39	the	the	DT
cord-001835-0s7ok4uw	588	40	compound	compound	NN
cord-001835-0s7ok4uw	588	41	's	's	POS
cord-001835-0s7ok4uw	588	42	solubility	solubility	NN
cord-001835-0s7ok4uw	588	43	in	in	IN
cord-001835-0s7ok4uw	588	44	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	588	45	solution	solution	NN
cord-001835-0s7ok4uw	588	46	.	.	.
cord-001835-0s7ok4uw	589	1	Similar	similar	JJ
cord-001835-0s7ok4uw	589	2	bivalent	bivalent	NN
cord-001835-0s7ok4uw	589	3	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	589	4	have	have	VBP
cord-001835-0s7ok4uw	589	5	been	be	VBN
cord-001835-0s7ok4uw	589	6	proven	prove	VBN
cord-001835-0s7ok4uw	589	7	to	to	TO
cord-001835-0s7ok4uw	589	8	synergistically	synergistically	RB
cord-001835-0s7ok4uw	589	9	increase	increase	VB
cord-001835-0s7ok4uw	589	10	their	-PRON-	PRP$
cord-001835-0s7ok4uw	589	11	efficacy	efficacy	NN
cord-001835-0s7ok4uw	589	12	.	.	.
cord-001835-0s7ok4uw	590	1	Biophysical	biophysical	JJ
cord-001835-0s7ok4uw	590	2	evaluation	evaluation	NN
cord-001835-0s7ok4uw	590	3	by	by	IN
cord-001835-0s7ok4uw	590	4	means	mean	NNS
cord-001835-0s7ok4uw	590	5	of	of	IN
cord-001835-0s7ok4uw	590	6	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	590	7	polarization	polarization	NN
cord-001835-0s7ok4uw	591	1	(	(	-LRB-
cord-001835-0s7ok4uw	591	2	FP	FP	NNP
cord-001835-0s7ok4uw	591	3	)	)	-RRB-
cord-001835-0s7ok4uw	591	4	inhibition	inhibition	NN
cord-001835-0s7ok4uw	591	5	competition	competition	NN
cord-001835-0s7ok4uw	591	6	assays	assay	NNS
cord-001835-0s7ok4uw	591	7	,	,	,
cord-001835-0s7ok4uw	591	8	revealed	reveal	VBD
cord-001835-0s7ok4uw	591	9	an	an	DT
cord-001835-0s7ok4uw	591	10	increase	increase	NN
cord-001835-0s7ok4uw	591	11	of	of	IN
cord-001835-0s7ok4uw	591	12	the	the	DT
cord-001835-0s7ok4uw	591	13	half	half	NN
cord-001835-0s7ok4uw	591	14	maximal	maximal	JJ
cord-001835-0s7ok4uw	591	15	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	591	16	concentration	concentration	NN
cord-001835-0s7ok4uw	591	17	(	(	-LRB-
cord-001835-0s7ok4uw	591	18	IC50	IC50	NNP
cord-001835-0s7ok4uw	591	19	)	)	-RRB-
cord-001835-0s7ok4uw	591	20	from	from	IN
cord-001835-0s7ok4uw	591	21	approximately	approximately	RB
cord-001835-0s7ok4uw	591	22	81	81	CD
cord-001835-0s7ok4uw	591	23	lM	lm	NN
cord-001835-0s7ok4uw	591	24	for	for	IN
cord-001835-0s7ok4uw	591	25	the	the	DT
cord-001835-0s7ok4uw	591	26	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	591	27	phenyl	phenyl	NN
cord-001835-0s7ok4uw	591	28	phosphonate	phosphonate	NNP
cord-001835-0s7ok4uw	591	29	to	to	IN
cord-001835-0s7ok4uw	591	30	approximately	approximately	RB
cord-001835-0s7ok4uw	591	31	1.8	1.8	CD
cord-001835-0s7ok4uw	591	32	lM	lm	NN
cord-001835-0s7ok4uw	591	33	for	for	IN
cord-001835-0s7ok4uw	591	34	the	the	DT
cord-001835-0s7ok4uw	591	35	bivalent	bivalent	JJ
cord-001835-0s7ok4uw	591	36	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	591	37	with	with	IN
cord-001835-0s7ok4uw	591	38	a	a	DT
cord-001835-0s7ok4uw	591	39	60Å	60å	CD
cord-001835-0s7ok4uw	591	40	linker	linker	NN
cord-001835-0s7ok4uw	591	41	.	.	.
cord-001835-0s7ok4uw	592	1	This	this	DT
cord-001835-0s7ok4uw	592	2	demonstrates	demonstrate	VBZ
cord-001835-0s7ok4uw	592	3	a	a	DT
cord-001835-0s7ok4uw	592	4	45-fold	45-fold	CD
cord-001835-0s7ok4uw	592	5	increase	increase	NN
cord-001835-0s7ok4uw	592	6	of	of	IN
cord-001835-0s7ok4uw	592	7	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	592	8	effect	effect	NN
cord-001835-0s7ok4uw	592	9	towards	towards	IN
cord-001835-0s7ok4uw	592	10	14	14	CD
cord-001835-0s7ok4uw	592	11	-	-	SYM
cord-001835-0s7ok4uw	592	12	3	3	CD
cord-001835-0s7ok4uw	592	13	-	-	SYM
cord-001835-0s7ok4uw	592	14	3	3	CD
cord-001835-0s7ok4uw	592	15	and	and	CC
cord-001835-0s7ok4uw	592	16	its	-PRON-	PRP$
cord-001835-0s7ok4uw	592	17	binding	bind	VBG
cord-001835-0s7ok4uw	592	18	partner	partner	NN
cord-001835-0s7ok4uw	592	19	peptide	peptide	NN
cord-001835-0s7ok4uw	592	20	mimic	mimic	VBP
cord-001835-0s7ok4uw	592	21	.	.	.
cord-001835-0s7ok4uw	593	1	Extensive	extensive	JJ
cord-001835-0s7ok4uw	593	2	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	593	3	,	,	,
cord-001835-0s7ok4uw	593	4	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	593	5	and	and	CC
cord-001835-0s7ok4uw	593	6	structural	structural	JJ
cord-001835-0s7ok4uw	593	7	analysis	analysis	NN
cord-001835-0s7ok4uw	593	8	of	of	IN
cord-001835-0s7ok4uw	593	9	the	the	DT
cord-001835-0s7ok4uw	593	10	interaction	interaction	NN
cord-001835-0s7ok4uw	593	11	is	be	VBZ
cord-001835-0s7ok4uw	593	12	in	in	IN
cord-001835-0s7ok4uw	593	13	progress	progress	NN
cord-001835-0s7ok4uw	593	14	.	.	.
cord-001835-0s7ok4uw	594	1	Phosphonic	Phosphonic	NNP
cord-001835-0s7ok4uw	594	2	moieties	moiety	NNS
cord-001835-0s7ok4uw	594	3	have	have	VBP
cord-001835-0s7ok4uw	594	4	been	be	VBN
cord-001835-0s7ok4uw	594	5	shown	show	VBN
cord-001835-0s7ok4uw	594	6	to	to	TO
cord-001835-0s7ok4uw	594	7	pass	pass	VB
cord-001835-0s7ok4uw	594	8	the	the	DT
cord-001835-0s7ok4uw	594	9	cell	cell	NN
cord-001835-0s7ok4uw	594	10	membrane	membrane	NN
cord-001835-0s7ok4uw	594	11	poorly	poorly	RB
cord-001835-0s7ok4uw	594	12	,	,	,
cord-001835-0s7ok4uw	594	13	due	due	IN
cord-001835-0s7ok4uw	594	14	to	to	IN
cord-001835-0s7ok4uw	594	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	594	16	highly	highly	RB
cord-001835-0s7ok4uw	594	17	charged	charge	VBN
cord-001835-0s7ok4uw	594	18	character	character	NN
cord-001835-0s7ok4uw	594	19	.	.	.
cord-001835-0s7ok4uw	595	1	By	by	IN
cord-001835-0s7ok4uw	595	2	being	be	VBG
cord-001835-0s7ok4uw	595	3	able	able	JJ
cord-001835-0s7ok4uw	595	4	to	to	TO
cord-001835-0s7ok4uw	595	5	specifically	specifically	RB
cord-001835-0s7ok4uw	595	6	inhibit	inhibit	VB
cord-001835-0s7ok4uw	595	7	the	the	DT
cord-001835-0s7ok4uw	595	8	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	595	9	interaction	interaction	NN
cord-001835-0s7ok4uw	595	10	between	between	IN
cord-001835-0s7ok4uw	595	11	14	14	CD
cord-001835-0s7ok4uw	595	12	-	-	SYM
cord-001835-0s7ok4uw	595	13	3	3	CD
cord-001835-0s7ok4uw	595	14	-	-	SYM
cord-001835-0s7ok4uw	595	15	3	3	CD
cord-001835-0s7ok4uw	595	16	and	and	CC
cord-001835-0s7ok4uw	595	17	APN	APN	NNP
cord-001835-0s7ok4uw	595	18	,	,	,
cord-001835-0s7ok4uw	595	19	these	these	DT
cord-001835-0s7ok4uw	595	20	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	595	21	are	be	VBP
cord-001835-0s7ok4uw	595	22	prevented	prevent	VBN
cord-001835-0s7ok4uw	595	23	from	from	IN
cord-001835-0s7ok4uw	595	24	interfering	interfere	VBG
cord-001835-0s7ok4uw	595	25	with	with	IN
cord-001835-0s7ok4uw	595	26	the	the	DT
cord-001835-0s7ok4uw	595	27	extensive	extensive	JJ
cord-001835-0s7ok4uw	595	28	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	595	29	14	14	CD
cord-001835-0s7ok4uw	595	30	-	-	SYM
cord-001835-0s7ok4uw	595	31	3	3	CD
cord-001835-0s7ok4uw	595	32	-	-	SYM
cord-001835-0s7ok4uw	595	33	3	3	CD
cord-001835-0s7ok4uw	595	34	interactome	interactome	NN
cord-001835-0s7ok4uw	595	35	.	.	.
cord-001835-0s7ok4uw	596	1	Hence	hence	RB
cord-001835-0s7ok4uw	596	2	,	,	,
cord-001835-0s7ok4uw	596	3	these	these	DT
cord-001835-0s7ok4uw	596	4	bivalent	bivalent	NN
cord-001835-0s7ok4uw	596	5	phenyl	phenyl	NNP
cord-001835-0s7ok4uw	596	6	phosphonate	phosphonate	NNP
cord-001835-0s7ok4uw	596	7	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	596	8	provide	provide	VBP
cord-001835-0s7ok4uw	596	9	a	a	DT
cord-001835-0s7ok4uw	596	10	promising	promising	JJ
cord-001835-0s7ok4uw	596	11	strategy	strategy	NN
cord-001835-0s7ok4uw	596	12	towards	towards	IN
cord-001835-0s7ok4uw	596	13	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	596	14	application	application	NN
cord-001835-0s7ok4uw	596	15	.	.	.
cord-001835-0s7ok4uw	597	1	The	the	DT
cord-001835-0s7ok4uw	597	2	Mre11	Mre11	NNP
cord-001835-0s7ok4uw	597	3	complex	complex	NN
cord-001835-0s7ok4uw	597	4	is	be	VBZ
cord-001835-0s7ok4uw	597	5	an	an	DT
cord-001835-0s7ok4uw	597	6	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	597	7	assembly	assembly	NN
cord-001835-0s7ok4uw	597	8	comprising	comprise	VBG
cord-001835-0s7ok4uw	597	9	of	of	IN
cord-001835-0s7ok4uw	597	10	dimmers	dimmer	NNS
cord-001835-0s7ok4uw	597	11	of	of	IN
cord-001835-0s7ok4uw	597	12	Mre11	Mre11	NNP
cord-001835-0s7ok4uw	597	13	and	and	CC
cord-001835-0s7ok4uw	597	14	Rad50	Rad50	NNP
cord-001835-0s7ok4uw	597	15	proteins	protein	NNS
cord-001835-0s7ok4uw	597	16	in	in	IN
cord-001835-0s7ok4uw	597	17	Archea	Archea	NNP
cord-001835-0s7ok4uw	597	18	and	and	CC
cord-001835-0s7ok4uw	597	19	additionally	additionally	RB
cord-001835-0s7ok4uw	597	20	Nbs1	nbs1	JJ
cord-001835-0s7ok4uw	597	21	subunit	subunit	NN
cord-001835-0s7ok4uw	597	22	present	present	NN
cord-001835-0s7ok4uw	597	23	in	in	IN
cord-001835-0s7ok4uw	597	24	Eukaryote	Eukaryote	NNP
cord-001835-0s7ok4uw	597	25	.	.	.
cord-001835-0s7ok4uw	598	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	598	2	is	be	VBZ
cord-001835-0s7ok4uw	598	3	the	the	DT
cord-001835-0s7ok4uw	598	4	central	central	JJ
cord-001835-0s7ok4uw	598	5	player	player	NN
cord-001835-0s7ok4uw	598	6	in	in	IN
cord-001835-0s7ok4uw	598	7	the	the	DT
cord-001835-0s7ok4uw	598	8	DNA	dna	NN
cord-001835-0s7ok4uw	598	9	damage	damage	NN
cord-001835-0s7ok4uw	598	10	response	response	NN
cord-001835-0s7ok4uw	598	11	-a	-a	HYPH
cord-001835-0s7ok4uw	598	12	functional	functional	JJ
cord-001835-0s7ok4uw	598	13	network	network	NN
cord-001835-0s7ok4uw	598	14	comprising	comprise	VBG
cord-001835-0s7ok4uw	598	15	DNA	dna	NN
cord-001835-0s7ok4uw	598	16	damage	damage	NN
cord-001835-0s7ok4uw	598	17	sensing	sensing	NN
cord-001835-0s7ok4uw	598	18	,	,	,
cord-001835-0s7ok4uw	598	19	signal	signal	NN
cord-001835-0s7ok4uw	598	20	transduction	transduction	NN
cord-001835-0s7ok4uw	598	21	,	,	,
cord-001835-0s7ok4uw	598	22	cell	cell	NN
cord-001835-0s7ok4uw	598	23	cycle	cycle	NN
cord-001835-0s7ok4uw	598	24	regulation	regulation	NN
cord-001835-0s7ok4uw	598	25	and	and	CC
cord-001835-0s7ok4uw	598	26	DNA	dna	NN
cord-001835-0s7ok4uw	598	27	double	double	JJ
cord-001835-0s7ok4uw	598	28	strand	strand	NN
cord-001835-0s7ok4uw	598	29	breaks	break	NNS
cord-001835-0s7ok4uw	598	30	(	(	-LRB-
cord-001835-0s7ok4uw	598	31	DSBs	dsb	NNS
cord-001835-0s7ok4uw	598	32	)	)	-RRB-
cord-001835-0s7ok4uw	598	33	repair	repair	VBP
cord-001835-0s7ok4uw	598	34	[	[	-LRB-
cord-001835-0s7ok4uw	598	35	1	1	CD
cord-001835-0s7ok4uw	598	36	]	]	-RRB-
cord-001835-0s7ok4uw	598	37	.	.	.
cord-001835-0s7ok4uw	599	1	Recent	recent	JJ
cord-001835-0s7ok4uw	599	2	structural	structural	JJ
cord-001835-0s7ok4uw	599	3	studies	study	NNS
cord-001835-0s7ok4uw	599	4	revealed	reveal	VBD
cord-001835-0s7ok4uw	599	5	that	that	IN
cord-001835-0s7ok4uw	599	6	Rad50	Rad50	NNP
cord-001835-0s7ok4uw	599	7	hinge	hinge	NN
cord-001835-0s7ok4uw	599	8	domain	domain	NN
cord-001835-0s7ok4uw	599	9	is	be	VBZ
cord-001835-0s7ok4uw	599	10	rather	rather	RB
cord-001835-0s7ok4uw	599	11	a	a	DT
cord-001835-0s7ok4uw	599	12	short	short	JJ
cord-001835-0s7ok4uw	599	13	kink	kink	NN
cord-001835-0s7ok4uw	599	14	in	in	IN
cord-001835-0s7ok4uw	599	15	the	the	DT
cord-001835-0s7ok4uw	599	16	coiled	coil	VBN
cord-001835-0s7ok4uw	599	17	-	-	HYPH
cord-001835-0s7ok4uw	599	18	coil	coil	NN
cord-001835-0s7ok4uw	599	19	region	region	NN
cord-001835-0s7ok4uw	599	20	and	and	CC
cord-001835-0s7ok4uw	599	21	adopts	adopt	VBZ
cord-001835-0s7ok4uw	599	22	unusual	unusual	JJ
cord-001835-0s7ok4uw	599	23	dimerization	dimerization	NN
cord-001835-0s7ok4uw	599	24	mode	mode	NN
cord-001835-0s7ok4uw	599	25	by	by	IN
cord-001835-0s7ok4uw	599	26	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	599	27	coordination	coordination	NN
cord-001835-0s7ok4uw	599	28	of	of	IN
cord-001835-0s7ok4uw	599	29	Zn(II	Zn(II	NNP
cord-001835-0s7ok4uw	599	30	)	)	-RRB-
cord-001835-0s7ok4uw	599	31	and	and	CC
cord-001835-0s7ok4uw	599	32	formation	formation	NN
cord-001835-0s7ok4uw	599	33	of	of	IN
cord-001835-0s7ok4uw	599	34	so	so	RB
cord-001835-0s7ok4uw	599	35	-	-	HYPH
cord-001835-0s7ok4uw	599	36	called	call	VBN
cord-001835-0s7ok4uw	599	37	zinc	zinc	NN
cord-001835-0s7ok4uw	599	38	hook	hook	NN
cord-001835-0s7ok4uw	599	39	domain	domain	NN
cord-001835-0s7ok4uw	599	40	[	[	-LRB-
cord-001835-0s7ok4uw	599	41	2	2	CD
cord-001835-0s7ok4uw	599	42	]	]	-RRB-
cord-001835-0s7ok4uw	599	43	.	.	.
cord-001835-0s7ok4uw	600	1	To	to	IN
cord-001835-0s7ok4uw	600	2	date	date	NN
cord-001835-0s7ok4uw	600	3	,	,	,
cord-001835-0s7ok4uw	600	4	very	very	RB
cord-001835-0s7ok4uw	600	5	limited	limited	JJ
cord-001835-0s7ok4uw	600	6	structural	structural	JJ
cord-001835-0s7ok4uw	600	7	data	datum	NNS
cord-001835-0s7ok4uw	600	8	on	on	IN
cord-001835-0s7ok4uw	600	9	the	the	DT
cord-001835-0s7ok4uw	600	10	zinc	zinc	NN
cord-001835-0s7ok4uw	600	11	hook	hook	NN
cord-001835-0s7ok4uw	600	12	domain	domain	NN
cord-001835-0s7ok4uw	600	13	have	have	VBP
cord-001835-0s7ok4uw	600	14	been	be	VBN
cord-001835-0s7ok4uw	600	15	reported	report	VBN
cord-001835-0s7ok4uw	600	16	,	,	,
cord-001835-0s7ok4uw	600	17	the	the	DT
cord-001835-0s7ok4uw	600	18	only	only	RB
cord-001835-0s7ok4uw	600	19	known	know	VBN
cord-001835-0s7ok4uw	600	20	structure	structure	NN
cord-001835-0s7ok4uw	600	21	was	be	VBD
cord-001835-0s7ok4uw	600	22	resolved	resolve	VBN
cord-001835-0s7ok4uw	600	23	for	for	IN
cord-001835-0s7ok4uw	600	24	Rad50	Rad50	NNP
cord-001835-0s7ok4uw	600	25	homologue	homologue	NN
cord-001835-0s7ok4uw	600	26	from	from	IN
cord-001835-0s7ok4uw	600	27	hyperthermophilic	hyperthermophilic	NNP
cord-001835-0s7ok4uw	600	28	archaeon	archaeon	NNP
cord-001835-0s7ok4uw	601	1	-P.	-P.	:
cord-001835-0s7ok4uw	602	1	furiosus	furiosus	NNP
cord-001835-0s7ok4uw	602	2	.	.	.
cord-001835-0s7ok4uw	603	1	Unusual	unusual	JJ
cord-001835-0s7ok4uw	603	2	Zn(II	zn(ii	CD
cord-001835-0s7ok4uw	603	3	)	)	-RRB-
cord-001835-0s7ok4uw	603	4	coordination	coordination	NN
cord-001835-0s7ok4uw	603	5	mode	mode	NN
cord-001835-0s7ok4uw	603	6	in	in	IN
cord-001835-0s7ok4uw	603	7	zinc	zinc	NN
cord-001835-0s7ok4uw	603	8	hook	hook	NN
cord-001835-0s7ok4uw	603	9	domain	domain	NN
cord-001835-0s7ok4uw	603	10	raises	raise	VBZ
cord-001835-0s7ok4uw	603	11	question	question	NN
cord-001835-0s7ok4uw	603	12	of	of	IN
cord-001835-0s7ok4uw	603	13	how	how	WRB
cord-001835-0s7ok4uw	603	14	zinc	zinc	NN
cord-001835-0s7ok4uw	603	15	hook	hook	NN
cord-001835-0s7ok4uw	603	16	domain	domain	NN
cord-001835-0s7ok4uw	603	17	assembles	assemble	VBZ
cord-001835-0s7ok4uw	603	18	to	to	TO
cord-001835-0s7ok4uw	603	19	form	form	VB
cord-001835-0s7ok4uw	603	20	interprotein	interprotein	NNP
cord-001835-0s7ok4uw	603	21	zinc	zinc	NN
cord-001835-0s7ok4uw	603	22	binding	bind	VBG
cord-001835-0s7ok4uw	603	23	site	site	NN
cord-001835-0s7ok4uw	603	24	with	with	IN
cord-001835-0s7ok4uw	603	25	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	603	26	stability	stability	NN
cord-001835-0s7ok4uw	603	27	to	to	TO
cord-001835-0s7ok4uw	603	28	function	function	VB
cord-001835-0s7ok4uw	603	29	at	at	IN
cord-001835-0s7ok4uw	603	30	low	low	JJ
cord-001835-0s7ok4uw	603	31	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	603	32	free	free	JJ
cord-001835-0s7ok4uw	603	33	Zn(II	zn(ii	NN
cord-001835-0s7ok4uw	603	34	)	)	-RRB-
cord-001835-0s7ok4uw	603	35	concentrations	concentration	NNS
cord-001835-0s7ok4uw	603	36	[	[	-LRB-
cord-001835-0s7ok4uw	603	37	3	3	CD
cord-001835-0s7ok4uw	603	38	]	]	-RRB-
cord-001835-0s7ok4uw	603	39	.	.	.
cord-001835-0s7ok4uw	604	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	604	2	study	study	NN
cord-001835-0s7ok4uw	604	3	on	on	IN
cord-001835-0s7ok4uw	604	4	minimal	minimal	JJ
cord-001835-0s7ok4uw	604	5	zinc	zinc	NN
cord-001835-0s7ok4uw	604	6	hook	hook	NN
cord-001835-0s7ok4uw	604	7	domain	domain	NN
cord-001835-0s7ok4uw	604	8	fragment	fragment	NN
cord-001835-0s7ok4uw	604	9	(	(	-LRB-
cord-001835-0s7ok4uw	604	10	14	14	CD
cord-001835-0s7ok4uw	604	11	aa	aa	NNP
cord-001835-0s7ok4uw	604	12	)	)	-RRB-
cord-001835-0s7ok4uw	604	13	indicated	indicate	VBD
cord-001835-0s7ok4uw	604	14	low	low	JJ
cord-001835-0s7ok4uw	604	15	femtomolar	femtomolar	NN
cord-001835-0s7ok4uw	604	16	affinity	affinity	NN
cord-001835-0s7ok4uw	604	17	towards	towards	IN
cord-001835-0s7ok4uw	604	18	Zn(II	Zn(II	NNP
cord-001835-0s7ok4uw	604	19	)	)	-RRB-
cord-001835-0s7ok4uw	605	1	[	[	-LRB-
cord-001835-0s7ok4uw	605	2	4	4	CD
cord-001835-0s7ok4uw	605	3	]	]	-RRB-
cord-001835-0s7ok4uw	605	4	.	.	.
cord-001835-0s7ok4uw	606	1	Extended	extended	JJ
cord-001835-0s7ok4uw	606	2	zinc	zinc	NN
cord-001835-0s7ok4uw	606	3	hook	hook	NN
cord-001835-0s7ok4uw	606	4	domain	domain	NN
cord-001835-0s7ok4uw	606	5	fragment	fragment	NN
cord-001835-0s7ok4uw	606	6	(	(	-LRB-
cord-001835-0s7ok4uw	606	7	45	45	CD
cord-001835-0s7ok4uw	606	8	aa	aa	NN
cord-001835-0s7ok4uw	606	9	)	)	-RRB-
cord-001835-0s7ok4uw	606	10	reveals	reveal	VBZ
cord-001835-0s7ok4uw	606	11	even	even	RB
cord-001835-0s7ok4uw	606	12	zeptomolar	zeptomolar	NNP
cord-001835-0s7ok4uw	606	13	affinity	affinity	NN
cord-001835-0s7ok4uw	606	14	.	.	.
cord-001835-0s7ok4uw	607	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	607	2	,	,	,
cord-001835-0s7ok4uw	607	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	607	4	main	main	JJ
cord-001835-0s7ok4uw	607	5	goal	goal	NN
cord-001835-0s7ok4uw	607	6	was	be	VBD
cord-001835-0s7ok4uw	607	7	to	to	TO
cord-001835-0s7ok4uw	607	8	probe	probe	VB
cord-001835-0s7ok4uw	607	9	the	the	DT
cord-001835-0s7ok4uw	607	10	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	607	11	and	and	CC
cord-001835-0s7ok4uw	607	12	structural	structural	JJ
cord-001835-0s7ok4uw	607	13	effects	effect	NNS
cord-001835-0s7ok4uw	607	14	that	that	WDT
cord-001835-0s7ok4uw	607	15	are	be	VBP
cord-001835-0s7ok4uw	607	16	hidden	hide	VBN
cord-001835-0s7ok4uw	607	17	in	in	IN
cord-001835-0s7ok4uw	607	18	the	the	DT
cord-001835-0s7ok4uw	607	19	small	small	JJ
cord-001835-0s7ok4uw	607	20	interprotein	interprotein	NNP
cord-001835-0s7ok4uw	607	21	interface	interface	NN
cord-001835-0s7ok4uw	607	22	and	and	CC
cord-001835-0s7ok4uw	607	23	are	be	VBP
cord-001835-0s7ok4uw	607	24	responsible	responsible	JJ
cord-001835-0s7ok4uw	607	25	for	for	IN
cord-001835-0s7ok4uw	607	26	the	the	DT
cord-001835-0s7ok4uw	607	27	dimerization	dimerization	NN
cord-001835-0s7ok4uw	607	28	of	of	IN
cord-001835-0s7ok4uw	607	29	the	the	DT
cord-001835-0s7ok4uw	607	30	large	large	JJ
cord-001835-0s7ok4uw	607	31	and	and	CC
cord-001835-0s7ok4uw	607	32	critical	critical	JJ
cord-001835-0s7ok4uw	607	33	protein	protein	NN
cord-001835-0s7ok4uw	607	34	machinery	machinery	NN
cord-001835-0s7ok4uw	607	35	.	.	.
cord-001835-0s7ok4uw	608	1	Probing	probe	VBG
cord-001835-0s7ok4uw	608	2	of	of	IN
cord-001835-0s7ok4uw	608	3	those	those	DT
cord-001835-0s7ok4uw	608	4	effects	effect	NNS
cord-001835-0s7ok4uw	608	5	was	be	VBD
cord-001835-0s7ok4uw	608	6	achieved	achieve	VBN
cord-001835-0s7ok4uw	608	7	by	by	IN
cord-001835-0s7ok4uw	608	8	detailed	detailed	JJ
cord-001835-0s7ok4uw	608	9	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	608	10	characterizations	characterization	NNS
cord-001835-0s7ok4uw	608	11	(	(	-LRB-
cord-001835-0s7ok4uw	608	12	including	include	VBG
cord-001835-0s7ok4uw	608	13	potentiometry	potentiometry	NN
cord-001835-0s7ok4uw	608	14	,	,	,
cord-001835-0s7ok4uw	608	15	NMR	NMR	NNP
cord-001835-0s7ok4uw	608	16	,	,	,
cord-001835-0s7ok4uw	608	17	HDX	HDX	NNP
cord-001835-0s7ok4uw	608	18	MS	MS	NNP
cord-001835-0s7ok4uw	608	19	and	and	CC
cord-001835-0s7ok4uw	608	20	CD	CD	NNP
cord-001835-0s7ok4uw	608	21	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	608	22	)	)	-RRB-
cord-001835-0s7ok4uw	608	23	of	of	IN
cord-001835-0s7ok4uw	608	24	18	18	CD
cord-001835-0s7ok4uw	608	25	protein	protein	NN
cord-001835-0s7ok4uw	608	26	fragments	fragment	NNS
cord-001835-0s7ok4uw	608	27	of	of	IN
cord-001835-0s7ok4uw	608	28	zinc	zinc	NN
cord-001835-0s7ok4uw	608	29	hook	hook	NN
cord-001835-0s7ok4uw	608	30	domains	domain	NNS
cord-001835-0s7ok4uw	608	31	with	with	IN
cord-001835-0s7ok4uw	608	32	a	a	DT
cord-001835-0s7ok4uw	608	33	number	number	NN
cord-001835-0s7ok4uw	608	34	of	of	IN
cord-001835-0s7ok4uw	608	35	point	point	NN
cord-001835-0s7ok4uw	608	36	mutations	mutation	NNS
cord-001835-0s7ok4uw	608	37	.	.	.
cord-001835-0s7ok4uw	609	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	609	2	showed	show	VBD
cord-001835-0s7ok4uw	609	3	that	that	IN
cord-001835-0s7ok4uw	609	4	extremely	extremely	RB
cord-001835-0s7ok4uw	609	5	high	high	JJ
cord-001835-0s7ok4uw	609	6	stability	stability	NN
cord-001835-0s7ok4uw	609	7	of	of	IN
cord-001835-0s7ok4uw	609	8	zinc	zinc	NN
cord-001835-0s7ok4uw	609	9	hook	hook	NN
cord-001835-0s7ok4uw	609	10	domain	domain	NN
cord-001835-0s7ok4uw	609	11	from	from	IN
cord-001835-0s7ok4uw	609	12	P.	P.	NNP
cord-001835-0s7ok4uw	609	13	furiosus	furiosus	NNP
cord-001835-0s7ok4uw	609	14	is	be	VBZ
cord-001835-0s7ok4uw	609	15	achieved	achieve	VBN
cord-001835-0s7ok4uw	609	16	by	by	IN
cord-001835-0s7ok4uw	609	17	the	the	DT
cord-001835-0s7ok4uw	609	18	formation	formation	NN
cord-001835-0s7ok4uw	609	19	of	of	IN
cord-001835-0s7ok4uw	609	20	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	609	21	bond	bond	NN
cord-001835-0s7ok4uw	609	22	network	network	NN
cord-001835-0s7ok4uw	609	23	in	in	IN
cord-001835-0s7ok4uw	609	24	b	b	NN
cord-001835-0s7ok4uw	609	25	-	-	:
cord-001835-0s7ok4uw	609	26	hairpins	hairpin	NNS
cord-001835-0s7ok4uw	609	27	and	and	CC
cord-001835-0s7ok4uw	609	28	interprotein	interprotein	NNP
cord-001835-0s7ok4uw	609	29	hydrophobic	hydrophobic	NNP
cord-001835-0s7ok4uw	609	30	core	core	NN
cord-001835-0s7ok4uw	609	31	.	.	.
cord-001835-0s7ok4uw	610	1	Eindhoven	Eindhoven	NNP
cord-001835-0s7ok4uw	610	2	University	University	NNP
cord-001835-0s7ok4uw	610	3	of	of	IN
cord-001835-0s7ok4uw	610	4	Technology	Technology	NNP
cord-001835-0s7ok4uw	610	5	DNA	DNA	NNP
cord-001835-0s7ok4uw	610	6	-	-	HYPH
cord-001835-0s7ok4uw	610	7	based	base	VBN
cord-001835-0s7ok4uw	610	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	610	9	circuits	circuit	NNS
cord-001835-0s7ok4uw	610	10	have	have	VBP
cord-001835-0s7ok4uw	610	11	become	become	VBN
cord-001835-0s7ok4uw	610	12	a	a	DT
cord-001835-0s7ok4uw	610	13	very	very	RB
cord-001835-0s7ok4uw	610	14	attractive	attractive	JJ
cord-001835-0s7ok4uw	610	15	tool	tool	NN
cord-001835-0s7ok4uw	610	16	in	in	IN
cord-001835-0s7ok4uw	610	17	molecular	molecular	JJ
cord-001835-0s7ok4uw	610	18	imaging	imaging	NN
cord-001835-0s7ok4uw	610	19	,	,	,
cord-001835-0s7ok4uw	610	20	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	610	21	biology	biology	NN
cord-001835-0s7ok4uw	610	22	,	,	,
cord-001835-0s7ok4uw	610	23	molecular	molecular	JJ
cord-001835-0s7ok4uw	610	24	diagnostics	diagnostic	NNS
cord-001835-0s7ok4uw	610	25	and	and	CC
cord-001835-0s7ok4uw	610	26	biomolecular	biomolecular	JJ
cord-001835-0s7ok4uw	610	27	computing	computing	NN
cord-001835-0s7ok4uw	610	28	.	.	.
cord-001835-0s7ok4uw	611	1	The	the	DT
cord-001835-0s7ok4uw	611	2	highly	highly	RB
cord-001835-0s7ok4uw	611	3	modular	modular	JJ
cord-001835-0s7ok4uw	611	4	and	and	CC
cord-001835-0s7ok4uw	611	5	predictable	predictable	JJ
cord-001835-0s7ok4uw	611	6	nature	nature	NN
cord-001835-0s7ok4uw	611	7	of	of	IN
cord-001835-0s7ok4uw	611	8	Watson	Watson	NNP
cord-001835-0s7ok4uw	611	9	-	-	HYPH
cord-001835-0s7ok4uw	611	10	Crick	Crick	NNP
cord-001835-0s7ok4uw	611	11	base	base	NN
cord-001835-0s7ok4uw	611	12	pairing	pairing	NN
cord-001835-0s7ok4uw	611	13	allows	allow	VBZ
cord-001835-0s7ok4uw	611	14	the	the	DT
cord-001835-0s7ok4uw	611	15	construction	construction	NN
cord-001835-0s7ok4uw	611	16	of	of	IN
cord-001835-0s7ok4uw	611	17	complex	complex	JJ
cord-001835-0s7ok4uw	611	18	circuits	circuit	NNS
cord-001835-0s7ok4uw	611	19	using	use	VBG
cord-001835-0s7ok4uw	611	20	a	a	DT
cord-001835-0s7ok4uw	611	21	limited	limited	JJ
cord-001835-0s7ok4uw	611	22	set	set	NN
cord-001835-0s7ok4uw	611	23	of	of	IN
cord-001835-0s7ok4uw	611	24	logic	logic	NN
cord-001835-0s7ok4uw	611	25	gates	gate	NNS
cord-001835-0s7ok4uw	611	26	and	and	CC
cord-001835-0s7ok4uw	611	27	building	building	NN
cord-001835-0s7ok4uw	611	28	blocks	block	NNS
cord-001835-0s7ok4uw	611	29	.	.	.
cord-001835-0s7ok4uw	612	1	However	however	RB
cord-001835-0s7ok4uw	612	2	,	,	,
cord-001835-0s7ok4uw	612	3	the	the	DT
cord-001835-0s7ok4uw	612	4	lack	lack	NN
cord-001835-0s7ok4uw	612	5	of	of	IN
cord-001835-0s7ok4uw	612	6	generic	generic	JJ
cord-001835-0s7ok4uw	612	7	approaches	approach	NNS
cord-001835-0s7ok4uw	612	8	to	to	TO
cord-001835-0s7ok4uw	612	9	interface	interface	NN
cord-001835-0s7ok4uw	612	10	DNA	dna	NN
cord-001835-0s7ok4uw	612	11	-	-	HYPH
cord-001835-0s7ok4uw	612	12	based	base	VBN
cord-001835-0s7ok4uw	612	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	612	14	circuits	circuit	NNS
cord-001835-0s7ok4uw	612	15	with	with	IN
cord-001835-0s7ok4uw	612	16	protein	protein	NN
cord-001835-0s7ok4uw	612	17	activity	activity	NN
cord-001835-0s7ok4uw	612	18	limits	limit	VBZ
cord-001835-0s7ok4uw	612	19	their	-PRON-	PRP$
cord-001835-0s7ok4uw	612	20	application	application	NN
cord-001835-0s7ok4uw	612	21	in	in	IN
cord-001835-0s7ok4uw	612	22	biomedicine	biomedicine	NN
cord-001835-0s7ok4uw	612	23	and	and	CC
cord-001835-0s7ok4uw	612	24	molecular	molecular	JJ
cord-001835-0s7ok4uw	612	25	diagnostics	diagnostic	NNS
cord-001835-0s7ok4uw	612	26	.	.	.
cord-001835-0s7ok4uw	613	1	Here	here	RB
cord-001835-0s7ok4uw	613	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	613	3	present	present	VBP
cord-001835-0s7ok4uw	613	4	a	a	DT
cord-001835-0s7ok4uw	613	5	new	new	JJ
cord-001835-0s7ok4uw	613	6	,	,	,
cord-001835-0s7ok4uw	613	7	highly	highly	RB
cord-001835-0s7ok4uw	613	8	modular	modular	JJ
cord-001835-0s7ok4uw	613	9	approach	approach	NN
cord-001835-0s7ok4uw	613	10	to	to	TO
cord-001835-0s7ok4uw	613	11	control	control	VB
cord-001835-0s7ok4uw	613	12	the	the	DT
cord-001835-0s7ok4uw	613	13	activity	activity	NN
cord-001835-0s7ok4uw	613	14	of	of	IN
cord-001835-0s7ok4uw	613	15	a	a	DT
cord-001835-0s7ok4uw	613	16	reporter	reporter	NN
cord-001835-0s7ok4uw	613	17	enzyme	enzyme	NN
cord-001835-0s7ok4uw	613	18	based	base	VBN
cord-001835-0s7ok4uw	613	19	on	on	IN
cord-001835-0s7ok4uw	613	20	the	the	DT
cord-001835-0s7ok4uw	613	21	DNA	dna	NN
cord-001835-0s7ok4uw	613	22	-	-	HYPH
cord-001835-0s7ok4uw	613	23	directed	direct	VBN
cord-001835-0s7ok4uw	613	24	assembly	assembly	NN
cord-001835-0s7ok4uw	613	25	and	and	CC
cord-001835-0s7ok4uw	613	26	disassembly	disassembly	NN
cord-001835-0s7ok4uw	613	27	of	of	IN
cord-001835-0s7ok4uw	613	28	a	a	DT
cord-001835-0s7ok4uw	613	29	complex	complex	NN
cord-001835-0s7ok4uw	613	30	between	between	IN
cord-001835-0s7ok4uw	613	31	TEM1-b	tem1-b	NN
cord-001835-0s7ok4uw	613	32	-	-	HYPH
cord-001835-0s7ok4uw	613	33	lactamase	lactamase	NN
cord-001835-0s7ok4uw	613	34	and	and	CC
cord-001835-0s7ok4uw	613	35	its	-PRON-	PRP$
cord-001835-0s7ok4uw	613	36	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	613	37	protein	protein	NN
cord-001835-0s7ok4uw	613	38	BLIP	blip	NN
cord-001835-0s7ok4uw	613	39	.	.	.
cord-001835-0s7ok4uw	614	1	Both	both	DT
cord-001835-0s7ok4uw	614	2	proteins	protein	NNS
cord-001835-0s7ok4uw	614	3	are	be	VBP
cord-001835-0s7ok4uw	614	4	conjugated	conjugate	VBN
cord-001835-0s7ok4uw	614	5	to	to	IN
cord-001835-0s7ok4uw	614	6	a	a	DT
cord-001835-0s7ok4uw	614	7	unique	unique	JJ
cord-001835-0s7ok4uw	614	8	oligonucleotide	oligonucleotide	NN
cord-001835-0s7ok4uw	614	9	,	,	,
cord-001835-0s7ok4uw	614	10	allowing	allow	VBG
cord-001835-0s7ok4uw	614	11	the	the	DT
cord-001835-0s7ok4uw	614	12	assembly	assembly	NN
cord-001835-0s7ok4uw	614	13	of	of	IN
cord-001835-0s7ok4uw	614	14	the	the	DT
cord-001835-0s7ok4uw	614	15	enzyme	enzyme	NN
cord-001835-0s7ok4uw	614	16	-	-	HYPH
cord-001835-0s7ok4uw	614	17	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	614	18	pair	pair	NN
cord-001835-0s7ok4uw	614	19	and	and	CC
cord-001835-0s7ok4uw	614	20	inhibition	inhibition	NN
cord-001835-0s7ok4uw	614	21	of	of	IN
cord-001835-0s7ok4uw	614	22	enzyme	enzyme	NN
cord-001835-0s7ok4uw	614	23	activity	activity	NN
cord-001835-0s7ok4uw	614	24	by	by	IN
cord-001835-0s7ok4uw	614	25	the	the	DT
cord-001835-0s7ok4uw	614	26	addition	addition	NN
cord-001835-0s7ok4uw	614	27	of	of	IN
cord-001835-0s7ok4uw	614	28	a	a	DT
cord-001835-0s7ok4uw	614	29	complementary	complementary	JJ
cord-001835-0s7ok4uw	614	30	template	template	NN
cord-001835-0s7ok4uw	614	31	strand	strand	NN
cord-001835-0s7ok4uw	614	32	.	.	.
cord-001835-0s7ok4uw	615	1	Addition	addition	NN
cord-001835-0s7ok4uw	615	2	of	of	IN
cord-001835-0s7ok4uw	615	3	an	an	DT
cord-001835-0s7ok4uw	615	4	oligonucleotide	oligonucleotide	NN
cord-001835-0s7ok4uw	615	5	that	that	WDT
cord-001835-0s7ok4uw	615	6	is	be	VBZ
cord-001835-0s7ok4uw	615	7	complementary	complementary	JJ
cord-001835-0s7ok4uw	615	8	to	to	IN
cord-001835-0s7ok4uw	615	9	a	a	DT
cord-001835-0s7ok4uw	615	10	loop	loop	NN
cord-001835-0s7ok4uw	615	11	sequence	sequence	NN
cord-001835-0s7ok4uw	615	12	in	in	IN
cord-001835-0s7ok4uw	615	13	the	the	DT
cord-001835-0s7ok4uw	615	14	template	template	NN
cord-001835-0s7ok4uw	615	15	results	result	NNS
cord-001835-0s7ok4uw	615	16	in	in	IN
cord-001835-0s7ok4uw	615	17	the	the	DT
cord-001835-0s7ok4uw	615	18	formation	formation	NN
cord-001835-0s7ok4uw	615	19	of	of	IN
cord-001835-0s7ok4uw	615	20	a	a	DT
cord-001835-0s7ok4uw	615	21	rigid	rigid	JJ
cord-001835-0s7ok4uw	615	22	dsDNA	dsdna	RB
cord-001835-0s7ok4uw	615	23	spacer	spacer	NN
cord-001835-0s7ok4uw	615	24	that	that	WDT
cord-001835-0s7ok4uw	615	25	disrupts	disrupt	VBZ
cord-001835-0s7ok4uw	615	26	the	the	DT
cord-001835-0s7ok4uw	615	27	enzyme	enzyme	NN
cord-001835-0s7ok4uw	615	28	-	-	HYPH
cord-001835-0s7ok4uw	615	29	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	615	30	complex	complex	NN
cord-001835-0s7ok4uw	615	31	,	,	,
cord-001835-0s7ok4uw	615	32	restoring	restore	VBG
cord-001835-0s7ok4uw	615	33	enzyme	enzyme	NN
cord-001835-0s7ok4uw	615	34	activity	activity	NN
cord-001835-0s7ok4uw	615	35	.	.	.
cord-001835-0s7ok4uw	616	1	Using	use	VBG
cord-001835-0s7ok4uw	616	2	this	this	DT
cord-001835-0s7ok4uw	616	3	noncovalent	noncovalent	NN
cord-001835-0s7ok4uw	616	4	approach	approach	NN
cord-001835-0s7ok4uw	616	5	allowed	allow	VBD
cord-001835-0s7ok4uw	616	6	easy	easy	JJ
cord-001835-0s7ok4uw	616	7	tuning	tuning	NN
cord-001835-0s7ok4uw	616	8	of	of	IN
cord-001835-0s7ok4uw	616	9	the	the	DT
cord-001835-0s7ok4uw	616	10	template	template	NN
cord-001835-0s7ok4uw	616	11	and	and	CC
cord-001835-0s7ok4uw	616	12	target	target	NN
cord-001835-0s7ok4uw	616	13	sequences	sequence	NNS
cord-001835-0s7ok4uw	616	14	with	with	IN
cord-001835-0s7ok4uw	616	15	only	only	RB
cord-001835-0s7ok4uw	616	16	a	a	DT
cord-001835-0s7ok4uw	616	17	single	single	JJ
cord-001835-0s7ok4uw	616	18	set	set	NN
cord-001835-0s7ok4uw	616	19	of	of	IN
cord-001835-0s7ok4uw	616	20	oligonucleotide	oligonucleotide	RB
cord-001835-0s7ok4uw	616	21	-	-	HYPH
cord-001835-0s7ok4uw	616	22	functionalized	functionalize	VBN
cord-001835-0s7ok4uw	616	23	enzyme	enzyme	NN
cord-001835-0s7ok4uw	616	24	and	and	CC
cord-001835-0s7ok4uw	616	25	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	616	26	.	.	.
cord-001835-0s7ok4uw	617	1	To	to	TO
cord-001835-0s7ok4uw	617	2	show	show	VB
cord-001835-0s7ok4uw	617	3	the	the	DT
cord-001835-0s7ok4uw	617	4	modularity	modularity	NN
cord-001835-0s7ok4uw	617	5	of	of	IN
cord-001835-0s7ok4uw	617	6	the	the	DT
cord-001835-0s7ok4uw	617	7	system	system	NN
cord-001835-0s7ok4uw	617	8	,	,	,
cord-001835-0s7ok4uw	617	9	a	a	DT
cord-001835-0s7ok4uw	617	10	panel	panel	NN
cord-001835-0s7ok4uw	617	11	of	of	IN
cord-001835-0s7ok4uw	617	12	8	8	CD
cord-001835-0s7ok4uw	617	13	different	different	JJ
cord-001835-0s7ok4uw	617	14	template	template	NN
cord-001835-0s7ok4uw	617	15	sequences	sequence	NNS
cord-001835-0s7ok4uw	617	16	were	be	VBD
cord-001835-0s7ok4uw	617	17	selected	select	VBN
cord-001835-0s7ok4uw	617	18	.	.	.
cord-001835-0s7ok4uw	618	1	Only	only	RB
cord-001835-0s7ok4uw	618	2	in	in	IN
cord-001835-0s7ok4uw	618	3	the	the	DT
cord-001835-0s7ok4uw	618	4	presence	presence	NN
cord-001835-0s7ok4uw	618	5	of	of	IN
cord-001835-0s7ok4uw	618	6	their	-PRON-	PRP$
cord-001835-0s7ok4uw	618	7	complementary	complementary	JJ
cord-001835-0s7ok4uw	618	8	viral	viral	JJ
cord-001835-0s7ok4uw	618	9	DNA	dna	NN
cord-001835-0s7ok4uw	618	10	sequences	sequence	NNS
cord-001835-0s7ok4uw	618	11	restoration	restoration	NN
cord-001835-0s7ok4uw	618	12	of	of	IN
cord-001835-0s7ok4uw	618	13	enzyme	enzyme	NN
cord-001835-0s7ok4uw	618	14	activity	activity	NN
cord-001835-0s7ok4uw	618	15	was	be	VBD
cord-001835-0s7ok4uw	618	16	observed	observe	VBN
cord-001835-0s7ok4uw	618	17	.	.	.
cord-001835-0s7ok4uw	619	1	In	in	IN
cord-001835-0s7ok4uw	619	2	addition	addition	NN
cord-001835-0s7ok4uw	619	3	to	to	IN
cord-001835-0s7ok4uw	619	4	this	this	DT
cord-001835-0s7ok4uw	619	5	excellent	excellent	JJ
cord-001835-0s7ok4uw	619	6	specificity	specificity	NN
cord-001835-0s7ok4uw	619	7	the	the	DT
cord-001835-0s7ok4uw	619	8	system	system	NN
cord-001835-0s7ok4uw	619	9	showed	show	VBD
cord-001835-0s7ok4uw	619	10	to	to	IN
cord-001835-0s7ok4uw	619	11	by	by	IN
cord-001835-0s7ok4uw	619	12	higly	higly	RB
cord-001835-0s7ok4uw	619	13	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	619	14	towards	towards	IN
cord-001835-0s7ok4uw	619	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	619	16	target	target	NN
cord-001835-0s7ok4uw	619	17	,	,	,
cord-001835-0s7ok4uw	619	18	since	since	IN
cord-001835-0s7ok4uw	619	19	the	the	DT
cord-001835-0s7ok4uw	619	20	presence	presence	NN
cord-001835-0s7ok4uw	619	21	of	of	IN
cord-001835-0s7ok4uw	619	22	as	as	RB
cord-001835-0s7ok4uw	619	23	little	little	JJ
cord-001835-0s7ok4uw	619	24	as	as	IN
cord-001835-0s7ok4uw	619	25	2	2	CD
cord-001835-0s7ok4uw	619	26	fmol	fmol	NNS
cord-001835-0s7ok4uw	619	27	of	of	IN
cord-001835-0s7ok4uw	619	28	target	target	NN
cord-001835-0s7ok4uw	619	29	resulted	result	VBN
cord-001835-0s7ok4uw	619	30	in	in	IN
cord-001835-0s7ok4uw	619	31	an	an	DT
cord-001835-0s7ok4uw	619	32	observable	observable	JJ
cord-001835-0s7ok4uw	619	33	increase	increase	NN
cord-001835-0s7ok4uw	619	34	in	in	IN
cord-001835-0s7ok4uw	619	35	enzyme	enzyme	NN
cord-001835-0s7ok4uw	619	36	activity	activity	NN
cord-001835-0s7ok4uw	619	37	.	.	.
cord-001835-0s7ok4uw	620	1	The	the	DT
cord-001835-0s7ok4uw	620	2	use	use	NN
cord-001835-0s7ok4uw	620	3	of	of	IN
cord-001835-0s7ok4uw	620	4	a	a	DT
cord-001835-0s7ok4uw	620	5	stable	stable	JJ
cord-001835-0s7ok4uw	620	6	and	and	CC
cord-001835-0s7ok4uw	620	7	well	well	RB
cord-001835-0s7ok4uw	620	8	-	-	HYPH
cord-001835-0s7ok4uw	620	9	characterized	characterize	VBN
cord-001835-0s7ok4uw	620	10	enzyme	enzyme	NN
cord-001835-0s7ok4uw	620	11	-	-	HYPH
cord-001835-0s7ok4uw	620	12	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	620	13	pair	pair	NN
cord-001835-0s7ok4uw	620	14	,	,	,
cord-001835-0s7ok4uw	620	15	complemented	complement	VBN
cord-001835-0s7ok4uw	620	16	by	by	IN
cord-001835-0s7ok4uw	620	17	the	the	DT
cord-001835-0s7ok4uw	620	18	modular	modular	JJ
cord-001835-0s7ok4uw	620	19	design	design	NN
cord-001835-0s7ok4uw	620	20	of	of	IN
cord-001835-0s7ok4uw	620	21	our	-PRON-	PRP$
cord-001835-0s7ok4uw	620	22	reversible	reversible	JJ
cord-001835-0s7ok4uw	620	23	DNA	dna	NN
cord-001835-0s7ok4uw	620	24	-	-	HYPH
cord-001835-0s7ok4uw	620	25	directed	direct	VBN
cord-001835-0s7ok4uw	620	26	protein	protein	NN
cord-001835-0s7ok4uw	620	27	switch	switch	NN
cord-001835-0s7ok4uw	620	28	make	make	VBP
cord-001835-0s7ok4uw	620	29	it	-PRON-	PRP
cord-001835-0s7ok4uw	620	30	an	an	DT
cord-001835-0s7ok4uw	620	31	attractive	attractive	JJ
cord-001835-0s7ok4uw	620	32	system	system	NN
cord-001835-0s7ok4uw	620	33	to	to	TO
cord-001835-0s7ok4uw	620	34	implement	implement	VB
cord-001835-0s7ok4uw	620	35	in	in	IN
cord-001835-0s7ok4uw	620	36	DNA	dna	NN
cord-001835-0s7ok4uw	620	37	-	-	HYPH
cord-001835-0s7ok4uw	620	38	based	base	VBN
cord-001835-0s7ok4uw	620	39	molecular	molecular	JJ
cord-001835-0s7ok4uw	620	40	circuits	circuit	NNS
cord-001835-0s7ok4uw	620	41	.	.	.
cord-001835-0s7ok4uw	621	1	Several	several	JJ
cord-001835-0s7ok4uw	621	2	studies	study	NNS
cord-001835-0s7ok4uw	621	3	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	621	4	important	important	JJ
cord-001835-0s7ok4uw	621	5	roles	role	NNS
cord-001835-0s7ok4uw	621	6	of	of	IN
cord-001835-0s7ok4uw	621	7	human	human	JJ
cord-001835-0s7ok4uw	621	8	Carbonic	Carbonic	NNP
cord-001835-0s7ok4uw	621	9	anhydrases	anhydrase	NNS
cord-001835-0s7ok4uw	621	10	(	(	-LRB-
cord-001835-0s7ok4uw	621	11	hCAs	hcas	LS
cord-001835-0s7ok4uw	621	12	)	)	-RRB-
cord-001835-0s7ok4uw	621	13	in	in	IN
cord-001835-0s7ok4uw	621	14	a	a	DT
cord-001835-0s7ok4uw	621	15	variety	variety	NN
cord-001835-0s7ok4uw	621	16	of	of	IN
cord-001835-0s7ok4uw	621	17	physiological	physiological	JJ
cord-001835-0s7ok4uw	621	18	and	and	CC
cord-001835-0s7ok4uw	621	19	pathological	pathological	JJ
cord-001835-0s7ok4uw	621	20	processes	process	NNS
cord-001835-0s7ok4uw	621	21	.	.	.
cord-001835-0s7ok4uw	622	1	Consequently	consequently	RB
cord-001835-0s7ok4uw	622	2	,	,	,
cord-001835-0s7ok4uw	622	3	in	in	IN
cord-001835-0s7ok4uw	622	4	recent	recent	JJ
cord-001835-0s7ok4uw	622	5	years	year	NNS
cord-001835-0s7ok4uw	622	6	the	the	DT
cord-001835-0s7ok4uw	622	7	12	12	CD
cord-001835-0s7ok4uw	622	8	catalytically	catalytically	RB
cord-001835-0s7ok4uw	622	9	active	active	JJ
cord-001835-0s7ok4uw	622	10	hCA	hca	NN
cord-001835-0s7ok4uw	622	11	isoforms	isoform	NNS
cord-001835-0s7ok4uw	622	12	have	have	VBP
cord-001835-0s7ok4uw	622	13	become	become	VBN
cord-001835-0s7ok4uw	622	14	an	an	DT
cord-001835-0s7ok4uw	622	15	interesting	interesting	JJ
cord-001835-0s7ok4uw	622	16	target	target	NN
cord-001835-0s7ok4uw	622	17	for	for	IN
cord-001835-0s7ok4uw	622	18	the	the	DT
cord-001835-0s7ok4uw	622	19	design	design	NN
cord-001835-0s7ok4uw	622	20	of	of	IN
cord-001835-0s7ok4uw	622	21	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	622	22	with	with	IN
cord-001835-0s7ok4uw	622	23	biomedical	biomedical	JJ
cord-001835-0s7ok4uw	622	24	applications	application	NNS
cord-001835-0s7ok4uw	622	25	[	[	-LRB-
cord-001835-0s7ok4uw	622	26	1	1	CD
cord-001835-0s7ok4uw	622	27	]	]	-RRB-
cord-001835-0s7ok4uw	622	28	.	.	.
cord-001835-0s7ok4uw	623	1	Derivatized	Derivatized	NNP
cord-001835-0s7ok4uw	623	2	sulfonamides	sulfonamide	NNS
cord-001835-0s7ok4uw	623	3	of	of	IN
cord-001835-0s7ok4uw	623	4	type	type	NN
cord-001835-0s7ok4uw	623	5	R	r	NN
cord-001835-0s7ok4uw	623	6	-	-	HYPH
cord-001835-0s7ok4uw	623	7	SO2NH2	so2nh2	NN
cord-001835-0s7ok4uw	623	8	represent	represent	VBP
cord-001835-0s7ok4uw	623	9	the	the	DT
cord-001835-0s7ok4uw	623	10	class	class	NN
cord-001835-0s7ok4uw	623	11	of	of	IN
cord-001835-0s7ok4uw	623	12	CA	CA	NNP
cord-001835-0s7ok4uw	623	13	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	623	14	(	(	-LRB-
cord-001835-0s7ok4uw	623	15	CAIs	CAIs	NNP
cord-001835-0s7ok4uw	623	16	)	)	-RRB-
cord-001835-0s7ok4uw	623	17	mostly	mostly	RB
cord-001835-0s7ok4uw	623	18	used	use	VBN
cord-001835-0s7ok4uw	623	19	and	and	CC
cord-001835-0s7ok4uw	623	20	best	best	RB
cord-001835-0s7ok4uw	623	21	characterized	characterize	VBN
cord-001835-0s7ok4uw	623	22	.	.	.
cord-001835-0s7ok4uw	624	1	The	the	DT
cord-001835-0s7ok4uw	624	2	large	large	JJ
cord-001835-0s7ok4uw	624	3	number	number	NN
cord-001835-0s7ok4uw	624	4	of	of	IN
cord-001835-0s7ok4uw	624	5	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	624	6	studies	study	NNS
cord-001835-0s7ok4uw	624	7	so	so	RB
cord-001835-0s7ok4uw	624	8	far	far	RB
cord-001835-0s7ok4uw	624	9	available	available	JJ
cord-001835-0s7ok4uw	624	10	on	on	IN
cord-001835-0s7ok4uw	624	11	these	these	DT
cord-001835-0s7ok4uw	624	12	molecules	molecule	NNS
cord-001835-0s7ok4uw	624	13	clarified	clarify	VBD
cord-001835-0s7ok4uw	624	14	the	the	DT
cord-001835-0s7ok4uw	624	15	main	main	JJ
cord-001835-0s7ok4uw	624	16	factors	factor	NNS
cord-001835-0s7ok4uw	624	17	responsible	responsible	JJ
cord-001835-0s7ok4uw	624	18	for	for	IN
cord-001835-0s7ok4uw	624	19	the	the	DT
cord-001835-0s7ok4uw	624	20	binding	binding	NN
cord-001835-0s7ok4uw	624	21	of	of	IN
cord-001835-0s7ok4uw	624	22	the	the	DT
cord-001835-0s7ok4uw	624	23	sulfonamide	sulfonamide	NN
cord-001835-0s7ok4uw	624	24	moiety	moiety	NN
cord-001835-0s7ok4uw	624	25	to	to	IN
cord-001835-0s7ok4uw	624	26	the	the	DT
cord-001835-0s7ok4uw	624	27	CA	CA	NNP
cord-001835-0s7ok4uw	624	28	active	active	JJ
cord-001835-0s7ok4uw	624	29	site	site	NN
cord-001835-0s7ok4uw	624	30	.	.	.
cord-001835-0s7ok4uw	625	1	1	1	LS
cord-001835-0s7ok4uw	626	1	In	in	IN
cord-001835-0s7ok4uw	626	2	particular	particular	JJ
cord-001835-0s7ok4uw	626	3	,	,	,
cord-001835-0s7ok4uw	626	4	it	-PRON-	PRP
cord-001835-0s7ok4uw	626	5	has	have	VBZ
cord-001835-0s7ok4uw	626	6	been	be	VBN
cord-001835-0s7ok4uw	626	7	highlighted	highlight	VBN
cord-001835-0s7ok4uw	626	8	that	that	IN
cord-001835-0s7ok4uw	626	9	even	even	RB
cord-001835-0s7ok4uw	626	10	though	though	IN
cord-001835-0s7ok4uw	626	11	these	these	DT
cord-001835-0s7ok4uw	626	12	molecules	molecule	NNS
cord-001835-0s7ok4uw	626	13	generally	generally	RB
cord-001835-0s7ok4uw	626	14	behave	behave	VBP
cord-001835-0s7ok4uw	626	15	as	as	RB
cord-001835-0s7ok4uw	626	16	very	very	RB
cord-001835-0s7ok4uw	626	17	potent	potent	JJ
cord-001835-0s7ok4uw	626	18	CAIs	cai	NNS
cord-001835-0s7ok4uw	626	19	,	,	,
cord-001835-0s7ok4uw	626	20	they	-PRON-	PRP
cord-001835-0s7ok4uw	626	21	do	do	VBP
cord-001835-0s7ok4uw	626	22	not	not	RB
cord-001835-0s7ok4uw	626	23	show	show	VB
cord-001835-0s7ok4uw	626	24	selectivity	selectivity	NN
cord-001835-0s7ok4uw	626	25	for	for	IN
cord-001835-0s7ok4uw	626	26	the	the	DT
cord-001835-0s7ok4uw	626	27	different	different	JJ
cord-001835-0s7ok4uw	626	28	isoforms	isoform	NNS
cord-001835-0s7ok4uw	626	29	.	.	.
cord-001835-0s7ok4uw	627	1	Indeed	indeed	RB
cord-001835-0s7ok4uw	627	2	,	,	,
cord-001835-0s7ok4uw	627	3	the	the	DT
cord-001835-0s7ok4uw	627	4	sulfonamide	sulfonamide	NN
cord-001835-0s7ok4uw	627	5	moiety	moiety	NN
cord-001835-0s7ok4uw	627	6	plays	play	VBZ
cord-001835-0s7ok4uw	627	7	a	a	DT
cord-001835-0s7ok4uw	627	8	predominant	predominant	JJ
cord-001835-0s7ok4uw	627	9	role	role	NN
cord-001835-0s7ok4uw	627	10	in	in	IN
cord-001835-0s7ok4uw	627	11	the	the	DT
cord-001835-0s7ok4uw	627	12	interaction	interaction	NN
cord-001835-0s7ok4uw	627	13	with	with	IN
cord-001835-0s7ok4uw	627	14	the	the	DT
cord-001835-0s7ok4uw	627	15	enzyme	enzyme	NN
cord-001835-0s7ok4uw	627	16	,	,	,
cord-001835-0s7ok4uw	627	17	while	while	IN
cord-001835-0s7ok4uw	627	18	any	any	DT
cord-001835-0s7ok4uw	627	19	change	change	NN
cord-001835-0s7ok4uw	627	20	in	in	IN
cord-001835-0s7ok4uw	627	21	the	the	DT
cord-001835-0s7ok4uw	627	22	nature	nature	NN
cord-001835-0s7ok4uw	627	23	of	of	IN
cord-001835-0s7ok4uw	627	24	the	the	DT
cord-001835-0s7ok4uw	627	25	R	r	NN
cord-001835-0s7ok4uw	627	26	substituent	substituent	NN
cord-001835-0s7ok4uw	627	27	has	have	VBZ
cord-001835-0s7ok4uw	627	28	generally	generally	RB
cord-001835-0s7ok4uw	627	29	a	a	DT
cord-001835-0s7ok4uw	627	30	rather	rather	RB
cord-001835-0s7ok4uw	627	31	marginal	marginal	JJ
cord-001835-0s7ok4uw	627	32	effect	effect	NN
cord-001835-0s7ok4uw	627	33	on	on	IN
cord-001835-0s7ok4uw	627	34	the	the	DT
cord-001835-0s7ok4uw	627	35	enzyme	enzyme	NN
cord-001835-0s7ok4uw	627	36	-	-	HYPH
cord-001835-0s7ok4uw	627	37	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	627	38	affinity	affinity	NN
cord-001835-0s7ok4uw	627	39	.	.	.
cord-001835-0s7ok4uw	628	1	These	these	DT
cord-001835-0s7ok4uw	628	2	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	628	3	make	make	VBP
cord-001835-0s7ok4uw	628	4	difficult	difficult	JJ
cord-001835-0s7ok4uw	628	5	the	the	DT
cord-001835-0s7ok4uw	628	6	design	design	NN
cord-001835-0s7ok4uw	628	7	of	of	IN
cord-001835-0s7ok4uw	628	8	sulfonamide	sulfonamide	NN
cord-001835-0s7ok4uw	628	9	derivatives	derivative	NNS
cord-001835-0s7ok4uw	628	10	selective	selective	JJ
cord-001835-0s7ok4uw	628	11	for	for	IN
cord-001835-0s7ok4uw	628	12	the	the	DT
cord-001835-0s7ok4uw	628	13	different	different	JJ
cord-001835-0s7ok4uw	628	14	CA	CA	NNP
cord-001835-0s7ok4uw	628	15	isoforms	isoform	NNS
cord-001835-0s7ok4uw	628	16	.	.	.
cord-001835-0s7ok4uw	629	1	Consequently	consequently	RB
cord-001835-0s7ok4uw	629	2	,	,	,
cord-001835-0s7ok4uw	629	3	much	much	JJ
cord-001835-0s7ok4uw	629	4	efforts	effort	NNS
cord-001835-0s7ok4uw	629	5	were	be	VBD
cord-001835-0s7ok4uw	629	6	dedicated	dedicate	VBN
cord-001835-0s7ok4uw	629	7	in	in	IN
cord-001835-0s7ok4uw	629	8	last	last	JJ
cord-001835-0s7ok4uw	629	9	years	year	NNS
cord-001835-0s7ok4uw	629	10	to	to	IN
cord-001835-0s7ok4uw	629	11	the	the	DT
cord-001835-0s7ok4uw	629	12	development	development	NN
cord-001835-0s7ok4uw	629	13	of	of	IN
cord-001835-0s7ok4uw	629	14	new	new	JJ
cord-001835-0s7ok4uw	629	15	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	629	16	that	that	WDT
cord-001835-0s7ok4uw	629	17	,	,	,
cord-001835-0s7ok4uw	629	18	although	although	IN
cord-001835-0s7ok4uw	629	19	presenting	present	VBG
cord-001835-0s7ok4uw	629	20	lower	low	JJR
cord-001835-0s7ok4uw	629	21	affinity	affinity	NN
cord-001835-0s7ok4uw	629	22	for	for	IN
cord-001835-0s7ok4uw	629	23	the	the	DT
cord-001835-0s7ok4uw	629	24	CA	CA	NNP
cord-001835-0s7ok4uw	629	25	active	active	JJ
cord-001835-0s7ok4uw	629	26	site	site	NN
cord-001835-0s7ok4uw	629	27	,	,	,
cord-001835-0s7ok4uw	629	28	would	would	MD
cord-001835-0s7ok4uw	629	29	be	be	VB
cord-001835-0s7ok4uw	629	30	able	able	JJ
cord-001835-0s7ok4uw	629	31	to	to	TO
cord-001835-0s7ok4uw	629	32	be	be	VB
cord-001835-0s7ok4uw	629	33	more	more	RBR
cord-001835-0s7ok4uw	629	34	selective	selective	JJ
cord-001835-0s7ok4uw	629	35	toward	toward	IN
cord-001835-0s7ok4uw	629	36	the	the	DT
cord-001835-0s7ok4uw	629	37	different	different	JJ
cord-001835-0s7ok4uw	629	38	isoforms	isoform	NNS
cord-001835-0s7ok4uw	629	39	.	.	.
cord-001835-0s7ok4uw	630	1	Carboxylic	carboxylic	JJ
cord-001835-0s7ok4uw	630	2	acids	acid	NNS
cord-001835-0s7ok4uw	630	3	have	have	VBP
cord-001835-0s7ok4uw	630	4	been	be	VBN
cord-001835-0s7ok4uw	630	5	recently	recently	RB
cord-001835-0s7ok4uw	630	6	investigated	investigate	VBN
cord-001835-0s7ok4uw	630	7	as	as	IN
cord-001835-0s7ok4uw	630	8	CAIs	CAIs	NNP
cord-001835-0s7ok4uw	630	9	,	,	,
cord-001835-0s7ok4uw	630	10	showing	show	VBG
cord-001835-0s7ok4uw	630	11	that	that	IN
cord-001835-0s7ok4uw	630	12	these	these	DT
cord-001835-0s7ok4uw	630	13	molecules	molecule	NNS
cord-001835-0s7ok4uw	630	14	can	can	MD
cord-001835-0s7ok4uw	630	15	adopt	adopt	VB
cord-001835-0s7ok4uw	630	16	different	different	JJ
cord-001835-0s7ok4uw	630	17	binding	bind	VBG
cord-001835-0s7ok4uw	630	18	modes	mode	NNS
cord-001835-0s7ok4uw	630	19	to	to	IN
cord-001835-0s7ok4uw	630	20	the	the	DT
cord-001835-0s7ok4uw	630	21	enzyme	enzyme	NN
cord-001835-0s7ok4uw	630	22	active	active	JJ
cord-001835-0s7ok4uw	630	23	site	site	NN
cord-001835-0s7ok4uw	630	24	.	.	.
cord-001835-0s7ok4uw	631	1	In	in	IN
cord-001835-0s7ok4uw	631	2	particular	particular	JJ
cord-001835-0s7ok4uw	631	3	,	,	,
cord-001835-0s7ok4uw	631	4	they	-PRON-	PRP
cord-001835-0s7ok4uw	631	5	can	can	MD
cord-001835-0s7ok4uw	631	6	coordinate	coordinate	VB
cord-001835-0s7ok4uw	631	7	directly	directly	RB
cord-001835-0s7ok4uw	631	8	to	to	IN
cord-001835-0s7ok4uw	631	9	the	the	DT
cord-001835-0s7ok4uw	631	10	zinc	zinc	NN
cord-001835-0s7ok4uw	631	11	ion	ion	NN
cord-001835-0s7ok4uw	631	12	or	or	CC
cord-001835-0s7ok4uw	631	13	be	be	VB
cord-001835-0s7ok4uw	631	14	anchored	anchor	VBN
cord-001835-0s7ok4uw	631	15	to	to	IN
cord-001835-0s7ok4uw	631	16	the	the	DT
cord-001835-0s7ok4uw	631	17	zinc	zinc	NN
cord-001835-0s7ok4uw	631	18	-	-	HYPH
cord-001835-0s7ok4uw	631	19	bound	bind	VBN
cord-001835-0s7ok4uw	631	20	water	water	NN
cord-001835-0s7ok4uw	631	21	molecule	molecule	NN
cord-001835-0s7ok4uw	631	22	.	.	.
cord-001835-0s7ok4uw	632	1	However	however	RB
cord-001835-0s7ok4uw	632	2	,	,	,
cord-001835-0s7ok4uw	632	3	the	the	DT
cord-001835-0s7ok4uw	632	4	structural	structural	JJ
cord-001835-0s7ok4uw	632	5	reasons	reason	NNS
cord-001835-0s7ok4uw	632	6	responsible	responsible	JJ
cord-001835-0s7ok4uw	632	7	of	of	IN
cord-001835-0s7ok4uw	632	8	this	this	DT
cord-001835-0s7ok4uw	632	9	peculiar	peculiar	JJ
cord-001835-0s7ok4uw	632	10	behavior	behavior	NN
cord-001835-0s7ok4uw	632	11	have	have	VBP
cord-001835-0s7ok4uw	632	12	not	not	RB
cord-001835-0s7ok4uw	632	13	been	be	VBN
cord-001835-0s7ok4uw	632	14	clarified	clarify	VBN
cord-001835-0s7ok4uw	632	15	yet	yet	RB
cord-001835-0s7ok4uw	632	16	.	.	.
cord-001835-0s7ok4uw	633	1	In	in	IN
cord-001835-0s7ok4uw	633	2	a	a	DT
cord-001835-0s7ok4uw	633	3	general	general	JJ
cord-001835-0s7ok4uw	633	4	research	research	NN
cord-001835-0s7ok4uw	633	5	project	project	NN
cord-001835-0s7ok4uw	633	6	aimed	aim	VBN
cord-001835-0s7ok4uw	633	7	at	at	IN
cord-001835-0s7ok4uw	633	8	providing	provide	VBG
cord-001835-0s7ok4uw	633	9	insights	insight	NNS
cord-001835-0s7ok4uw	633	10	into	into	IN
cord-001835-0s7ok4uw	633	11	the	the	DT
cord-001835-0s7ok4uw	633	12	binding	binding	NN
cord-001835-0s7ok4uw	633	13	mode	mode	NN
cord-001835-0s7ok4uw	633	14	of	of	IN
cord-001835-0s7ok4uw	633	15	these	these	DT
cord-001835-0s7ok4uw	633	16	molecules	molecule	NNS
cord-001835-0s7ok4uw	633	17	to	to	IN
cord-001835-0s7ok4uw	633	18	CAs	CAs	NNP
cord-001835-0s7ok4uw	633	19	,	,	,
cord-001835-0s7ok4uw	633	20	we	-PRON-	PRP
cord-001835-0s7ok4uw	633	21	have	have	VBP
cord-001835-0s7ok4uw	633	22	undertaken	undertake	VBN
cord-001835-0s7ok4uw	633	23	the	the	DT
cord-001835-0s7ok4uw	633	24	characterization	characterization	NN
cord-001835-0s7ok4uw	633	25	of	of	IN
cord-001835-0s7ok4uw	633	26	two	two	CD
cord-001835-0s7ok4uw	633	27	carboxylic	carboxylic	JJ
cord-001835-0s7ok4uw	633	28	acids	acid	NNS
cord-001835-0s7ok4uw	633	29	,	,	,
cord-001835-0s7ok4uw	633	30	namely	namely	RB
cord-001835-0s7ok4uw	633	31	an	an	DT
cord-001835-0s7ok4uw	633	32	ortho	ortho	NNP
cord-001835-0s7ok4uw	633	33	-	-	HYPH
cord-001835-0s7ok4uw	633	34	substituted	substitute	VBN
cord-001835-0s7ok4uw	633	35	benzoic	benzoic	NN
cord-001835-0s7ok4uw	633	36	acid	acid	NN
cord-001835-0s7ok4uw	633	37	[	[	-LRB-
cord-001835-0s7ok4uw	633	38	2	2	CD
cord-001835-0s7ok4uw	633	39	]	]	-RRB-
cord-001835-0s7ok4uw	633	40	and	and	CC
cord-001835-0s7ok4uw	633	41	a	a	DT
cord-001835-0s7ok4uw	633	42	saccharine	saccharine	JJ
cord-001835-0s7ok4uw	633	43	derivative	derivative	NN
cord-001835-0s7ok4uw	633	44	,	,	,
cord-001835-0s7ok4uw	633	45	by	by	IN
cord-001835-0s7ok4uw	633	46	means	mean	NNS
cord-001835-0s7ok4uw	633	47	of	of	IN
cord-001835-0s7ok4uw	633	48	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	633	49	,	,	,
cord-001835-0s7ok4uw	633	50	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	633	51	and	and	CC
cord-001835-0s7ok4uw	633	52	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	633	53	studies	study	NNS
cord-001835-0s7ok4uw	633	54	.	.	.
cord-001835-0s7ok4uw	633	55	 	 	_SP
cord-001835-0s7ok4uw	634	1	Exploring	explore	VBG
cord-001835-0s7ok4uw	634	2	the	the	DT
cord-001835-0s7ok4uw	634	3	mechanism	mechanism	NN
cord-001835-0s7ok4uw	634	4	of	of	IN
cord-001835-0s7ok4uw	634	5	fibril	fibril	NNP
cord-001835-0s7ok4uw	634	6	formation	formation	NN
cord-001835-0s7ok4uw	634	7	using	use	VBG
cord-001835-0s7ok4uw	634	8	fluorescently	fluorescently	RB
cord-001835-0s7ok4uw	634	9	labelled	label	VBN
cord-001835-0s7ok4uw	634	10	human	human	JJ
cord-001835-0s7ok4uw	634	11	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	634	12	variants	variant	NNS
cord-001835-0s7ok4uw	634	13	Ana	Ana	NNP
cord-001835-0s7ok4uw	634	14	Bernardo	Bernardo	NNP
cord-001835-0s7ok4uw	634	15	Gancedo	Gancedo	NNP
cord-001835-0s7ok4uw	634	16	1	1	CD
cord-001835-0s7ok4uw	634	17	1	1	CD
cord-001835-0s7ok4uw	634	18	'	'	''
cord-001835-0s7ok4uw	634	19	Exploring	explore	VBG
cord-001835-0s7ok4uw	634	20	the	the	DT
cord-001835-0s7ok4uw	634	21	mechanism	mechanism	NN
cord-001835-0s7ok4uw	634	22	of	of	IN
cord-001835-0s7ok4uw	634	23	fibril	fibril	NNP
cord-001835-0s7ok4uw	634	24	formation	formation	NN
cord-001835-0s7ok4uw	634	25	using	use	VBG
cord-001835-0s7ok4uw	634	26	fluorescently	fluorescently	RB
cord-001835-0s7ok4uw	634	27	labelled	label	VBN
cord-001835-0s7ok4uw	634	28	human	human	JJ
cord-001835-0s7ok4uw	634	29	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	634	30	variants	variant	NNS
cord-001835-0s7ok4uw	634	31	'	'	POS
cord-001835-0s7ok4uw	634	32	Human	human	JJ
cord-001835-0s7ok4uw	634	33	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	634	34	is	be	VBZ
cord-001835-0s7ok4uw	634	35	a	a	DT
cord-001835-0s7ok4uw	634	36	widely	widely	RB
cord-001835-0s7ok4uw	634	37	characterised	characterise	VBN
cord-001835-0s7ok4uw	634	38	protein	protein	NN
cord-001835-0s7ok4uw	634	39	whose	whose	WP$
cord-001835-0s7ok4uw	634	40	mutational	mutational	JJ
cord-001835-0s7ok4uw	634	41	variants	variant	NNS
cord-001835-0s7ok4uw	634	42	misfold	misfold	VBP
cord-001835-0s7ok4uw	634	43	into	into	IN
cord-001835-0s7ok4uw	634	44	fibrils	fibril	NNS
cord-001835-0s7ok4uw	634	45	that	that	WDT
cord-001835-0s7ok4uw	634	46	are	be	VBP
cord-001835-0s7ok4uw	634	47	associated	associate	VBN
cord-001835-0s7ok4uw	634	48	with	with	IN
cord-001835-0s7ok4uw	634	49	systemic	systemic	JJ
cord-001835-0s7ok4uw	634	50	amyloidosis	amyloidosis	NN
cord-001835-0s7ok4uw	634	51	(	(	-LRB-
cord-001835-0s7ok4uw	634	52	1	1	CD
cord-001835-0s7ok4uw	634	53	)	)	-RRB-
cord-001835-0s7ok4uw	634	54	.	.	.
cord-001835-0s7ok4uw	635	1	Although	although	IN
cord-001835-0s7ok4uw	635	2	the	the	DT
cord-001835-0s7ok4uw	635	3	process	process	NN
cord-001835-0s7ok4uw	635	4	of	of	IN
cord-001835-0s7ok4uw	635	5	aggregation	aggregation	NN
cord-001835-0s7ok4uw	635	6	for	for	IN
cord-001835-0s7ok4uw	635	7	human	human	JJ
cord-001835-0s7ok4uw	635	8	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	635	9	has	have	VBZ
cord-001835-0s7ok4uw	635	10	been	be	VBN
cord-001835-0s7ok4uw	635	11	well	well	RB
cord-001835-0s7ok4uw	635	12	studied	study	VBN
cord-001835-0s7ok4uw	635	13	,	,	,
cord-001835-0s7ok4uw	635	14	the	the	DT
cord-001835-0s7ok4uw	635	15	details	detail	NNS
cord-001835-0s7ok4uw	635	16	of	of	IN
cord-001835-0s7ok4uw	635	17	early	early	JJ
cord-001835-0s7ok4uw	635	18	events	event	NNS
cord-001835-0s7ok4uw	635	19	within	within	IN
cord-001835-0s7ok4uw	635	20	this	this	DT
cord-001835-0s7ok4uw	635	21	process	process	NN
cord-001835-0s7ok4uw	635	22	are	be	VBP
cord-001835-0s7ok4uw	635	23	not	not	RB
cord-001835-0s7ok4uw	635	24	fully	fully	RB
cord-001835-0s7ok4uw	635	25	characterised	characterise	VBN
cord-001835-0s7ok4uw	635	26	.	.	.
cord-001835-0s7ok4uw	636	1	Single	single	JJ
cord-001835-0s7ok4uw	636	2	molecule	molecule	NN
cord-001835-0s7ok4uw	636	3	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	636	4	microscopy	microscopy	NN
cord-001835-0s7ok4uw	636	5	has	have	VBZ
cord-001835-0s7ok4uw	636	6	been	be	VBN
cord-001835-0s7ok4uw	636	7	used	use	VBN
cord-001835-0s7ok4uw	636	8	to	to	TO
cord-001835-0s7ok4uw	636	9	determine	determine	VB
cord-001835-0s7ok4uw	636	10	the	the	DT
cord-001835-0s7ok4uw	636	11	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	636	12	distributions	distribution	NNS
cord-001835-0s7ok4uw	636	13	present	present	JJ
cord-001835-0s7ok4uw	636	14	in	in	IN
cord-001835-0s7ok4uw	636	15	the	the	DT
cord-001835-0s7ok4uw	636	16	aggregation	aggregation	NN
cord-001835-0s7ok4uw	636	17	process	process	NN
cord-001835-0s7ok4uw	636	18	of	of	IN
cord-001835-0s7ok4uw	636	19	a	a	DT
cord-001835-0s7ok4uw	636	20	number	number	NN
cord-001835-0s7ok4uw	636	21	of	of	IN
cord-001835-0s7ok4uw	636	22	disease	disease	NN
cord-001835-0s7ok4uw	636	23	-	-	HYPH
cord-001835-0s7ok4uw	636	24	related	relate	VBN
cord-001835-0s7ok4uw	636	25	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	636	26	disordered	disordered	JJ
cord-001835-0s7ok4uw	636	27	proteins	protein	NNS
cord-001835-0s7ok4uw	636	28	(	(	-LRB-
cord-001835-0s7ok4uw	636	29	IDPs	IDPs	NNP
cord-001835-0s7ok4uw	636	30	)	)	-RRB-
cord-001835-0s7ok4uw	636	31	(	(	-LRB-
cord-001835-0s7ok4uw	636	32	2	2	CD
cord-001835-0s7ok4uw	636	33	)	)	-RRB-
cord-001835-0s7ok4uw	636	34	.	.	.
cord-001835-0s7ok4uw	637	1	Recent	recent	JJ
cord-001835-0s7ok4uw	637	2	advances	advance	NNS
cord-001835-0s7ok4uw	637	3	in	in	IN
cord-001835-0s7ok4uw	637	4	site	site	NN
cord-001835-0s7ok4uw	637	5	-	-	HYPH
cord-001835-0s7ok4uw	637	6	specific	specific	JJ
cord-001835-0s7ok4uw	637	7	labelling	labelling	NN
cord-001835-0s7ok4uw	637	8	of	of	IN
cord-001835-0s7ok4uw	637	9	human	human	JJ
cord-001835-0s7ok4uw	637	10	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	637	11	(	(	-LRB-
cord-001835-0s7ok4uw	637	12	3	3	LS
cord-001835-0s7ok4uw	637	13	)	)	-RRB-
cord-001835-0s7ok4uw	637	14	have	have	VBP
cord-001835-0s7ok4uw	637	15	made	make	VBN
cord-001835-0s7ok4uw	637	16	this	this	DT
cord-001835-0s7ok4uw	637	17	protein	protein	NN
cord-001835-0s7ok4uw	637	18	amenable	amenable	JJ
cord-001835-0s7ok4uw	637	19	to	to	IN
cord-001835-0s7ok4uw	637	20	these	these	DT
cord-001835-0s7ok4uw	637	21	single	single	JJ
cord-001835-0s7ok4uw	637	22	molecule	molecule	NN
cord-001835-0s7ok4uw	637	23	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	637	24	studies	study	NNS
cord-001835-0s7ok4uw	637	25	.	.	.
cord-001835-0s7ok4uw	638	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	638	2	have	have	VBP
cord-001835-0s7ok4uw	638	3	introduced	introduce	VBN
cord-001835-0s7ok4uw	638	4	Alexa	Alexa	NNP
cord-001835-0s7ok4uw	638	5	-	-	HYPH
cord-001835-0s7ok4uw	638	6	fluorophores	fluorophore	NNS
cord-001835-0s7ok4uw	638	7	into	into	IN
cord-001835-0s7ok4uw	638	8	the	the	DT
cord-001835-0s7ok4uw	638	9	I59	I59	NNP
cord-001835-0s7ok4uw	638	10	T	T	NNP
cord-001835-0s7ok4uw	638	11	variant	variant	NN
cord-001835-0s7ok4uw	638	12	of	of	IN
cord-001835-0s7ok4uw	638	13	human	human	JJ
cord-001835-0s7ok4uw	638	14	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	638	15	and	and	CC
cord-001835-0s7ok4uw	638	16	have	have	VBP
cord-001835-0s7ok4uw	638	17	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	638	18	that	that	IN
cord-001835-0s7ok4uw	638	19	the	the	DT
cord-001835-0s7ok4uw	638	20	process	process	NN
cord-001835-0s7ok4uw	638	21	of	of	IN
cord-001835-0s7ok4uw	638	22	in	in	FW
cord-001835-0s7ok4uw	638	23	vitro	vitro	FW
cord-001835-0s7ok4uw	638	24	fibril	fibril	NNP
cord-001835-0s7ok4uw	638	25	formation	formation	NN
cord-001835-0s7ok4uw	638	26	is	be	VBZ
cord-001835-0s7ok4uw	638	27	not	not	RB
cord-001835-0s7ok4uw	638	28	significantly	significantly	RB
cord-001835-0s7ok4uw	638	29	altered	alter	VBN
cord-001835-0s7ok4uw	638	30	.	.	.
cord-001835-0s7ok4uw	639	1	Using	use	VBG
cord-001835-0s7ok4uw	639	2	these	these	DT
cord-001835-0s7ok4uw	639	3	fluorophore	fluorophore	RB
cord-001835-0s7ok4uw	639	4	-	-	HYPH
cord-001835-0s7ok4uw	639	5	labelled	label	VBN
cord-001835-0s7ok4uw	639	6	proteins	protein	NNS
cord-001835-0s7ok4uw	639	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	639	8	can	can	MD
cord-001835-0s7ok4uw	639	9	apply	apply	VB
cord-001835-0s7ok4uw	639	10	single	single	JJ
cord-001835-0s7ok4uw	639	11	molecule	molecule	NN
cord-001835-0s7ok4uw	639	12	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	639	13	to	to	TO
cord-001835-0s7ok4uw	639	14	study	study	VB
cord-001835-0s7ok4uw	639	15	the	the	DT
cord-001835-0s7ok4uw	639	16	early	early	JJ
cord-001835-0s7ok4uw	639	17	aggregation	aggregation	NN
cord-001835-0s7ok4uw	639	18	events	event	NNS
cord-001835-0s7ok4uw	639	19	within	within	IN
cord-001835-0s7ok4uw	639	20	this	this	DT
cord-001835-0s7ok4uw	639	21	system	system	NN
cord-001835-0s7ok4uw	639	22	,	,	,
cord-001835-0s7ok4uw	639	23	allowing	allow	VBG
cord-001835-0s7ok4uw	639	24	us	-PRON-	PRP
cord-001835-0s7ok4uw	639	25	to	to	TO
cord-001835-0s7ok4uw	639	26	compare	compare	VB
cord-001835-0s7ok4uw	639	27	protein	protein	NN
cord-001835-0s7ok4uw	639	28	aggregation	aggregation	NN
cord-001835-0s7ok4uw	639	29	in	in	IN
cord-001835-0s7ok4uw	639	30	a	a	DT
cord-001835-0s7ok4uw	639	31	globular	globular	JJ
cord-001835-0s7ok4uw	639	32	protein	protein	NN
cord-001835-0s7ok4uw	639	33	and	and	CC
cord-001835-0s7ok4uw	639	34	with	with	IN
cord-001835-0s7ok4uw	639	35	the	the	DT
cord-001835-0s7ok4uw	639	36	aggregation	aggregation	NN
cord-001835-0s7ok4uw	639	37	process	process	NN
cord-001835-0s7ok4uw	639	38	of	of	IN
cord-001835-0s7ok4uw	639	39	IDP	IDP	NNP
cord-001835-0s7ok4uw	639	40	's	's	POS
cord-001835-0s7ok4uw	639	41	.	.	.
cord-001835-0s7ok4uw	640	1	ABSTRACT	abstract	JJ
cord-001835-0s7ok4uw	640	2	protein	protein	NN
cord-001835-0s7ok4uw	640	3	structure	structure	NN
cord-001835-0s7ok4uw	640	4	,	,	,
cord-001835-0s7ok4uw	640	5	folding	folding	NN
cord-001835-0s7ok4uw	640	6	and	and	CC
cord-001835-0s7ok4uw	640	7	function	function	NN
cord-001835-0s7ok4uw	640	8	,	,	,
cord-001835-0s7ok4uw	640	9	while	while	IN
cord-001835-0s7ok4uw	640	10	specific	specific	JJ
cord-001835-0s7ok4uw	640	11	interactions	interaction	NNS
cord-001835-0s7ok4uw	640	12	with	with	IN
cord-001835-0s7ok4uw	640	13	lipid	lipid	NN
cord-001835-0s7ok4uw	640	14	molecules	molecule	NNS
cord-001835-0s7ok4uw	640	15	can	can	MD
cord-001835-0s7ok4uw	640	16	also	also	RB
cord-001835-0s7ok4uw	640	17	contribute	contribute	VB
cord-001835-0s7ok4uw	640	18	towards	towards	IN
cord-001835-0s7ok4uw	640	19	the	the	DT
cord-001835-0s7ok4uw	640	20	biological	biological	JJ
cord-001835-0s7ok4uw	640	21	activity	activity	NN
cord-001835-0s7ok4uw	640	22	of	of	IN
cord-001835-0s7ok4uw	640	23	some	some	DT
cord-001835-0s7ok4uw	640	24	membrane	membrane	NN
cord-001835-0s7ok4uw	640	25	proteins	protein	NNS
cord-001835-0s7ok4uw	640	26	.	.	.
cord-001835-0s7ok4uw	641	1	Improving	improve	VBG
cord-001835-0s7ok4uw	641	2	understanding	understanding	NN
cord-001835-0s7ok4uw	641	3	of	of	IN
cord-001835-0s7ok4uw	641	4	the	the	DT
cord-001835-0s7ok4uw	641	5	interactions	interaction	NNS
cord-001835-0s7ok4uw	641	6	has	have	VBZ
cord-001835-0s7ok4uw	641	7	resulted	result	VBN
cord-001835-0s7ok4uw	641	8	in	in	IN
cord-001835-0s7ok4uw	641	9	the	the	DT
cord-001835-0s7ok4uw	641	10	development	development	NN
cord-001835-0s7ok4uw	641	11	of	of	IN
cord-001835-0s7ok4uw	641	12	artificial	artificial	JJ
cord-001835-0s7ok4uw	641	13	lipid	lipid	NN
cord-001835-0s7ok4uw	641	14	systems	system	NNS
cord-001835-0s7ok4uw	641	15	that	that	WDT
cord-001835-0s7ok4uw	641	16	allow	allow	VBP
cord-001835-0s7ok4uw	641	17	the	the	DT
cord-001835-0s7ok4uw	641	18	bilayer	bilayer	NN
cord-001835-0s7ok4uw	641	19	properties	property	NNS
cord-001835-0s7ok4uw	641	20	to	to	TO
cord-001835-0s7ok4uw	641	21	be	be	VB
cord-001835-0s7ok4uw	641	22	rationally	rationally	RB
cord-001835-0s7ok4uw	641	23	manipulated	manipulate	VBN
cord-001835-0s7ok4uw	641	24	in	in	IN
cord-001835-0s7ok4uw	641	25	vitro	vitro	FW
cord-001835-0s7ok4uw	641	26	to	to	TO
cord-001835-0s7ok4uw	641	27	control	control	VB
cord-001835-0s7ok4uw	641	28	protein	protein	NN
cord-001835-0s7ok4uw	641	29	behaviour	behaviour	NN
cord-001835-0s7ok4uw	641	30	.	.	.
cord-001835-0s7ok4uw	642	1	The	the	DT
cord-001835-0s7ok4uw	642	2	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	642	3	transporter	transporter	NN
cord-001835-0s7ok4uw	642	4	LacY	LacY	NNP
cord-001835-0s7ok4uw	642	5	is	be	VBZ
cord-001835-0s7ok4uw	642	6	a	a	DT
cord-001835-0s7ok4uw	642	7	well	well	RB
cord-001835-0s7ok4uw	642	8	known	know	VBN
cord-001835-0s7ok4uw	642	9	integral	integral	JJ
cord-001835-0s7ok4uw	642	10	membrane	membrane	NN
cord-001835-0s7ok4uw	642	11	protein	protein	NN
cord-001835-0s7ok4uw	642	12	from	from	IN
cord-001835-0s7ok4uw	642	13	the	the	DT
cord-001835-0s7ok4uw	642	14	Major	Major	NNP
cord-001835-0s7ok4uw	642	15	Facilitor	Facilitor	NNP
cord-001835-0s7ok4uw	642	16	Superfamily	Superfamily	NNP
cord-001835-0s7ok4uw	642	17	,	,	,
cord-001835-0s7ok4uw	642	18	responsible	responsible	JJ
cord-001835-0s7ok4uw	642	19	for	for	IN
cord-001835-0s7ok4uw	642	20	the	the	DT
cord-001835-0s7ok4uw	642	21	protondriven	protondriven	JJ
cord-001835-0s7ok4uw	642	22	uptake	uptake	NN
cord-001835-0s7ok4uw	642	23	of	of	IN
cord-001835-0s7ok4uw	642	24	D	d	NN
cord-001835-0s7ok4uw	642	25	-	-	HYPH
cord-001835-0s7ok4uw	642	26	lactose	lactose	NN
cord-001835-0s7ok4uw	642	27	in	in	IN
cord-001835-0s7ok4uw	642	28	E.	E.	NNP
cord-001835-0s7ok4uw	642	29	coli	coli	NNS
cord-001835-0s7ok4uw	642	30	.	.	.
cord-001835-0s7ok4uw	643	1	With	with	IN
cord-001835-0s7ok4uw	643	2	a	a	DT
cord-001835-0s7ok4uw	643	3	high	high	JJ
cord-001835-0s7ok4uw	643	4	resolution	resolution	NN
cord-001835-0s7ok4uw	643	5	structure	structure	NN
cord-001835-0s7ok4uw	643	6	available	available	JJ
cord-001835-0s7ok4uw	643	7	and	and	CC
cord-001835-0s7ok4uw	643	8	considerable	considerable	JJ
cord-001835-0s7ok4uw	643	9	understanding	understanding	NN
cord-001835-0s7ok4uw	643	10	of	of	IN
cord-001835-0s7ok4uw	643	11	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	643	12	detail	detail	NN
cord-001835-0s7ok4uw	643	13	,	,	,
cord-001835-0s7ok4uw	643	14	and	and	CC
cord-001835-0s7ok4uw	643	15	with	with	IN
cord-001835-0s7ok4uw	643	16	observed	observed	JJ
cord-001835-0s7ok4uw	643	17	changes	change	NNS
cord-001835-0s7ok4uw	643	18	to	to	IN
cord-001835-0s7ok4uw	643	19	both	both	DT
cord-001835-0s7ok4uw	643	20	structure	structure	NN
cord-001835-0s7ok4uw	643	21	and	and	CC
cord-001835-0s7ok4uw	643	22	function	function	NN
cord-001835-0s7ok4uw	643	23	in	in	IN
cord-001835-0s7ok4uw	643	24	different	different	JJ
cord-001835-0s7ok4uw	643	25	bilayer	bilayer	NN
cord-001835-0s7ok4uw	643	26	environments	environment	NNS
cord-001835-0s7ok4uw	643	27	,	,	,
cord-001835-0s7ok4uw	643	28	LacY	LacY	NNP
cord-001835-0s7ok4uw	643	29	is	be	VBZ
cord-001835-0s7ok4uw	643	30	a	a	DT
cord-001835-0s7ok4uw	643	31	good	good	JJ
cord-001835-0s7ok4uw	643	32	model	model	NN
cord-001835-0s7ok4uw	643	33	system	system	NN
cord-001835-0s7ok4uw	643	34	for	for	IN
cord-001835-0s7ok4uw	643	35	examining	examine	VBG
cord-001835-0s7ok4uw	643	36	the	the	DT
cord-001835-0s7ok4uw	643	37	behaviour	behaviour	NN
cord-001835-0s7ok4uw	643	38	of	of	IN
cord-001835-0s7ok4uw	643	39	a	a	DT
cord-001835-0s7ok4uw	643	40	major	major	JJ
cord-001835-0s7ok4uw	643	41	class	class	NN
cord-001835-0s7ok4uw	643	42	of	of	IN
cord-001835-0s7ok4uw	643	43	membrane	membrane	NN
cord-001835-0s7ok4uw	643	44	proteins	protein	NNS
cord-001835-0s7ok4uw	643	45	in	in	IN
cord-001835-0s7ok4uw	643	46	these	these	DT
cord-001835-0s7ok4uw	643	47	lipid	lipid	NN
cord-001835-0s7ok4uw	643	48	systems	system	NNS
cord-001835-0s7ok4uw	643	49	.	.	.
cord-001835-0s7ok4uw	644	1	Purified	purify	VBN
cord-001835-0s7ok4uw	644	2	LacY	LacY	NNP
cord-001835-0s7ok4uw	644	3	has	have	VBZ
cord-001835-0s7ok4uw	644	4	been	be	VBN
cord-001835-0s7ok4uw	644	5	reconstituted	reconstitute	VBN
cord-001835-0s7ok4uw	644	6	into	into	IN
cord-001835-0s7ok4uw	644	7	liposomes	liposome	NNS
cord-001835-0s7ok4uw	644	8	and	and	CC
cord-001835-0s7ok4uw	644	9	droplet	droplet	NN
cord-001835-0s7ok4uw	644	10	interface	interface	NN
cord-001835-0s7ok4uw	644	11	bilayer	bilayer	NN
cord-001835-0s7ok4uw	644	12	systems	system	NNS
cord-001835-0s7ok4uw	644	13	of	of	IN
cord-001835-0s7ok4uw	644	14	varying	vary	VBG
cord-001835-0s7ok4uw	644	15	lipid	lipid	NN
cord-001835-0s7ok4uw	644	16	composition	composition	NN
cord-001835-0s7ok4uw	644	17	and	and	CC
cord-001835-0s7ok4uw	644	18	the	the	DT
cord-001835-0s7ok4uw	644	19	effect	effect	NN
cord-001835-0s7ok4uw	644	20	on	on	IN
cord-001835-0s7ok4uw	644	21	protein	protein	NN
cord-001835-0s7ok4uw	644	22	function	function	NN
cord-001835-0s7ok4uw	644	23	and	and	CC
cord-001835-0s7ok4uw	644	24	bilayer	bilayer	NN
cord-001835-0s7ok4uw	644	25	properties	property	NNS
cord-001835-0s7ok4uw	644	26	examined	examine	VBN
cord-001835-0s7ok4uw	644	27	.	.	.
cord-001835-0s7ok4uw	645	1	Targeting	target	VBG
cord-001835-0s7ok4uw	645	2	Abeta	Abeta	NNP
cord-001835-0s7ok4uw	645	3	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	645	4	by	by	IN
cord-001835-0s7ok4uw	645	5	Trehalose	Trehalose	NNP
cord-001835-0s7ok4uw	645	6	-	-	HYPH
cord-001835-0s7ok4uw	645	7	conjugated	conjugate	VBN
cord-001835-0s7ok4uw	645	8	peptides	peptide	NNS
cord-001835-0s7ok4uw	645	9	:	:	:
cord-001835-0s7ok4uw	645	10	a	a	DT
cord-001835-0s7ok4uw	645	11	molecular	molecular	JJ
cord-001835-0s7ok4uw	645	12	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	645	13	study	study	VBP
cord-001835-0s7ok4uw	645	14	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	645	15	's	's	POS
cord-001835-0s7ok4uw	645	16	disease	disease	NN
cord-001835-0s7ok4uw	645	17	(	(	-LRB-
cord-001835-0s7ok4uw	645	18	AD	ad	NN
cord-001835-0s7ok4uw	645	19	)	)	-RRB-
cord-001835-0s7ok4uw	645	20	is	be	VBZ
cord-001835-0s7ok4uw	645	21	currently	currently	RB
cord-001835-0s7ok4uw	645	22	one	one	CD
cord-001835-0s7ok4uw	645	23	of	of	IN
cord-001835-0s7ok4uw	645	24	the	the	DT
cord-001835-0s7ok4uw	645	25	most	most	RBS
cord-001835-0s7ok4uw	645	26	common	common	JJ
cord-001835-0s7ok4uw	645	27	and	and	CC
cord-001835-0s7ok4uw	645	28	devastating	devastating	JJ
cord-001835-0s7ok4uw	645	29	forms	form	NNS
cord-001835-0s7ok4uw	645	30	of	of	IN
cord-001835-0s7ok4uw	645	31	dementia	dementia	NN
cord-001835-0s7ok4uw	645	32	correlated	correlate	VBN
cord-001835-0s7ok4uw	645	33	with	with	IN
cord-001835-0s7ok4uw	645	34	beta	beta	JJ
cord-001835-0s7ok4uw	645	35	-	-	HYPH
cord-001835-0s7ok4uw	645	36	amyloid	amyloid	NN
cord-001835-0s7ok4uw	645	37	peptide	peptide	NN
cord-001835-0s7ok4uw	645	38	(	(	-LRB-
cord-001835-0s7ok4uw	645	39	Abeta	Abeta	NNP
cord-001835-0s7ok4uw	645	40	)	)	-RRB-
cord-001835-0s7ok4uw	645	41	accumulation	accumulation	NN
cord-001835-0s7ok4uw	645	42	in	in	IN
cord-001835-0s7ok4uw	645	43	human	human	JJ
cord-001835-0s7ok4uw	645	44	brain	brain	NN
cord-001835-0s7ok4uw	645	45	tissue	tissue	NN
cord-001835-0s7ok4uw	645	46	[	[	-LRB-
cord-001835-0s7ok4uw	645	47	1	1	CD
cord-001835-0s7ok4uw	645	48	,	,	,
cord-001835-0s7ok4uw	645	49	2	2	CD
cord-001835-0s7ok4uw	645	50	]	]	-RRB-
cord-001835-0s7ok4uw	645	51	.	.	.
cord-001835-0s7ok4uw	646	1	Inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	646	2	Abeta	Abeta	NNP
cord-001835-0s7ok4uw	646	3	selfoligomerization	selfoligomerization	NN
cord-001835-0s7ok4uw	646	4	in	in	IN
cord-001835-0s7ok4uw	646	5	brain	brain	NN
cord-001835-0s7ok4uw	646	6	tissue	tissue	NN
cord-001835-0s7ok4uw	646	7	remains	remain	VBZ
cord-001835-0s7ok4uw	646	8	one	one	CD
cord-001835-0s7ok4uw	646	9	of	of	IN
cord-001835-0s7ok4uw	646	10	the	the	DT
cord-001835-0s7ok4uw	646	11	main	main	JJ
cord-001835-0s7ok4uw	646	12	strategies	strategy	NNS
cord-001835-0s7ok4uw	646	13	to	to	TO
cord-001835-0s7ok4uw	646	14	prevent	prevent	VB
cord-001835-0s7ok4uw	646	15	or	or	CC
cord-001835-0s7ok4uw	646	16	treat	treat	VB
cord-001835-0s7ok4uw	646	17	this	this	DT
cord-001835-0s7ok4uw	646	18	disorder	disorder	NN
cord-001835-0s7ok4uw	646	19	.	.	.
cord-001835-0s7ok4uw	647	1	As	as	IN
cord-001835-0s7ok4uw	647	2	a	a	DT
cord-001835-0s7ok4uw	647	3	consequence	consequence	NN
cord-001835-0s7ok4uw	647	4	,	,	,
cord-001835-0s7ok4uw	647	5	in	in	IN
cord-001835-0s7ok4uw	647	6	recent	recent	JJ
cord-001835-0s7ok4uw	647	7	years	year	NNS
cord-001835-0s7ok4uw	647	8	much	much	JJ
cord-001835-0s7ok4uw	647	9	efforts	effort	NNS
cord-001835-0s7ok4uw	647	10	have	have	VBP
cord-001835-0s7ok4uw	647	11	been	be	VBN
cord-001835-0s7ok4uw	647	12	spent	spend	VBN
cord-001835-0s7ok4uw	647	13	in	in	IN
cord-001835-0s7ok4uw	647	14	the	the	DT
cord-001835-0s7ok4uw	647	15	understanding	understanding	NN
cord-001835-0s7ok4uw	647	16	of	of	IN
cord-001835-0s7ok4uw	647	17	the	the	DT
cord-001835-0s7ok4uw	647	18	amyloid	amyloid	NN
cord-001835-0s7ok4uw	647	19	fibril	fibril	NNP
cord-001835-0s7ok4uw	647	20	growth	growth	NN
cord-001835-0s7ok4uw	647	21	process	process	NN
cord-001835-0s7ok4uw	647	22	and	and	CC
cord-001835-0s7ok4uw	647	23	its	-PRON-	PRP$
cord-001835-0s7ok4uw	647	24	modulation	modulation	NN
cord-001835-0s7ok4uw	647	25	by	by	IN
cord-001835-0s7ok4uw	647	26	putative	putative	JJ
cord-001835-0s7ok4uw	647	27	drug	drug	NN
cord-001835-0s7ok4uw	647	28	molecules	molecule	NNS
cord-001835-0s7ok4uw	647	29	.	.	.
cord-001835-0s7ok4uw	648	1	An	an	DT
cord-001835-0s7ok4uw	648	2	interesting	interesting	JJ
cord-001835-0s7ok4uw	648	3	class	class	NN
cord-001835-0s7ok4uw	648	4	of	of	IN
cord-001835-0s7ok4uw	648	5	compounds	compound	NNS
cord-001835-0s7ok4uw	648	6	able	able	JJ
cord-001835-0s7ok4uw	648	7	to	to	TO
cord-001835-0s7ok4uw	648	8	prevent	prevent	VB
cord-001835-0s7ok4uw	648	9	Abeta	Abeta	NNP
cord-001835-0s7ok4uw	648	10	fibrillogenesis	fibrillogenesis	NN
cord-001835-0s7ok4uw	648	11	,	,	,
cord-001835-0s7ok4uw	648	12	is	be	VBZ
cord-001835-0s7ok4uw	648	13	represented	represent	VBN
cord-001835-0s7ok4uw	648	14	by	by	IN
cord-001835-0s7ok4uw	648	15	beta	beta	JJ
cord-001835-0s7ok4uw	648	16	-	-	HYPH
cord-001835-0s7ok4uw	648	17	sheet	sheet	NN
cord-001835-0s7ok4uw	648	18	-	-	HYPH
cord-001835-0s7ok4uw	648	19	breaker	breaker	NN
cord-001835-0s7ok4uw	648	20	(	(	-LRB-
cord-001835-0s7ok4uw	648	21	BSB	BSB	NNP
cord-001835-0s7ok4uw	648	22	)	)	-RRB-
cord-001835-0s7ok4uw	648	23	peptides	peptide	NNS
cord-001835-0s7ok4uw	648	24	[	[	-LRB-
cord-001835-0s7ok4uw	648	25	3	3	CD
cord-001835-0s7ok4uw	648	26	]	]	-RRB-
cord-001835-0s7ok4uw	648	27	.	.	.
cord-001835-0s7ok4uw	649	1	Although	although	IN
cord-001835-0s7ok4uw	649	2	these	these	DT
cord-001835-0s7ok4uw	649	3	molecules	molecule	NNS
cord-001835-0s7ok4uw	649	4	are	be	VBP
cord-001835-0s7ok4uw	649	5	thought	think	VBN
cord-001835-0s7ok4uw	649	6	to	to	TO
cord-001835-0s7ok4uw	649	7	recognize	recognize	VB
cord-001835-0s7ok4uw	649	8	in	in	IN
cord-001835-0s7ok4uw	649	9	a	a	DT
cord-001835-0s7ok4uw	649	10	self	self	NN
cord-001835-0s7ok4uw	649	11	-	-	HYPH
cord-001835-0s7ok4uw	649	12	complementary	complementary	JJ
cord-001835-0s7ok4uw	649	13	manner	manner	NN
cord-001835-0s7ok4uw	649	14	the	the	DT
cord-001835-0s7ok4uw	649	15	Abeta	Abeta	NNP
cord-001835-0s7ok4uw	649	16	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	649	17	core	core	NN
cord-001835-0s7ok4uw	649	18	region	region	NN
cord-001835-0s7ok4uw	649	19	,	,	,
cord-001835-0s7ok4uw	649	20	however	however	RB
cord-001835-0s7ok4uw	649	21	their	-PRON-	PRP$
cord-001835-0s7ok4uw	649	22	precise	precise	JJ
cord-001835-0s7ok4uw	649	23	mechanism	mechanism	NN
cord-001835-0s7ok4uw	649	24	of	of	IN
cord-001835-0s7ok4uw	649	25	interaction	interaction	NN
cord-001835-0s7ok4uw	649	26	is	be	VBZ
cord-001835-0s7ok4uw	649	27	still	still	RB
cord-001835-0s7ok4uw	649	28	unclear	unclear	JJ
cord-001835-0s7ok4uw	649	29	.	.	.
cord-001835-0s7ok4uw	650	1	In	in	IN
cord-001835-0s7ok4uw	650	2	this	this	DT
cord-001835-0s7ok4uw	650	3	context	context	NN
cord-001835-0s7ok4uw	650	4	,	,	,
cord-001835-0s7ok4uw	650	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	650	6	have	have	VBP
cord-001835-0s7ok4uw	650	7	studied	study	VBN
cord-001835-0s7ok4uw	650	8	the	the	DT
cord-001835-0s7ok4uw	650	9	structural	structural	JJ
cord-001835-0s7ok4uw	650	10	basis	basis	NN
cord-001835-0s7ok4uw	650	11	underlying	underlie	VBG
cord-001835-0s7ok4uw	650	12	the	the	DT
cord-001835-0s7ok4uw	650	13	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	650	14	effect	effect	NN
cord-001835-0s7ok4uw	650	15	of	of	IN
cord-001835-0s7ok4uw	650	16	Abeta(1	abeta(1	NN
cord-001835-0s7ok4uw	650	17	-	-	HYPH
cord-001835-0s7ok4uw	650	18	42	42	CD
cord-001835-0s7ok4uw	650	19	)	)	-RRB-
cord-001835-0s7ok4uw	650	20	fibrillogenesis	fibrillogenesis	NNP
cord-001835-0s7ok4uw	650	21	explicated	explicate	VBN
cord-001835-0s7ok4uw	650	22	by	by	IN
cord-001835-0s7ok4uw	650	23	two	two	CD
cord-001835-0s7ok4uw	650	24	promising	promising	JJ
cord-001835-0s7ok4uw	650	25	trehaloseconjugated	trehaloseconjugate	VBN
cord-001835-0s7ok4uw	650	26	BSB	BSB	NNP
cord-001835-0s7ok4uw	650	27	peptides	peptide	NNS
cord-001835-0s7ok4uw	650	28	(	(	-LRB-
cord-001835-0s7ok4uw	650	29	Ac	Ac	NNP
cord-001835-0s7ok4uw	650	30	-	-	HYPH
cord-001835-0s7ok4uw	650	31	LPFFD	LPFFD	NNP
cord-001835-0s7ok4uw	650	32	-	-	HYPH
cord-001835-0s7ok4uw	650	33	Th	Th	NNP
cord-001835-0s7ok4uw	650	34	(	(	-LRB-
cord-001835-0s7ok4uw	650	35	ThCT	ThCT	NNP
cord-001835-0s7ok4uw	650	36	)	)	-RRB-
cord-001835-0s7ok4uw	650	37	and	and	CC
cord-001835-0s7ok4uw	650	38	Th	Th	NNP
cord-001835-0s7ok4uw	650	39	-	-	HYPH
cord-001835-0s7ok4uw	650	40	Succinyl	Succinyl	NNP
cord-001835-0s7ok4uw	650	41	-	-	HYPH
cord-001835-0s7ok4uw	650	42	LPFFD	LPFFD	NNP
cord-001835-0s7ok4uw	650	43	-	-	HYPH
cord-001835-0s7ok4uw	650	44	NH2	NH2	NNP
cord-001835-0s7ok4uw	650	45	(	(	-LRB-
cord-001835-0s7ok4uw	650	46	ThNT	ThNT	NNP
cord-001835-0s7ok4uw	650	47	)	)	-RRB-
cord-001835-0s7ok4uw	650	48	)	)	-RRB-
cord-001835-0s7ok4uw	650	49	[	[	-LRB-
cord-001835-0s7ok4uw	650	50	4	4	LS
cord-001835-0s7ok4uw	650	51	]	]	-RRB-
cord-001835-0s7ok4uw	650	52	using	use	VBG
cord-001835-0s7ok4uw	650	53	an	an	DT
cord-001835-0s7ok4uw	650	54	all	all	DT
cord-001835-0s7ok4uw	650	55	-	-	HYPH
cord-001835-0s7ok4uw	650	56	atom	atom	NN
cord-001835-0s7ok4uw	650	57	molecular	molecular	JJ
cord-001835-0s7ok4uw	650	58	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	650	59	(	(	-LRB-
cord-001835-0s7ok4uw	650	60	MD	MD	NNP
cord-001835-0s7ok4uw	650	61	)	)	-RRB-
cord-001835-0s7ok4uw	650	62	approach	approach	VBP
cord-001835-0s7ok4uw	650	63	[	[	-LRB-
cord-001835-0s7ok4uw	650	64	5	5	CD
cord-001835-0s7ok4uw	650	65	,	,	,
cord-001835-0s7ok4uw	650	66	6	6	CD
cord-001835-0s7ok4uw	650	67	]	]	-RRB-
cord-001835-0s7ok4uw	650	68	.	.	.
cord-001835-0s7ok4uw	651	1	The	the	DT
cord-001835-0s7ok4uw	651	2	pentameric	pentameric	NN
cord-001835-0s7ok4uw	651	3	NMR	nmr	NN
cord-001835-0s7ok4uw	651	4	structure	structure	NN
cord-001835-0s7ok4uw	651	5	[	[	-LRB-
cord-001835-0s7ok4uw	651	6	7	7	CD
cord-001835-0s7ok4uw	651	7	]	]	-RRB-
cord-001835-0s7ok4uw	651	8	of	of	IN
cord-001835-0s7ok4uw	651	9	Abeta	Abeta	NNP
cord-001835-0s7ok4uw	651	10	has	have	VBZ
cord-001835-0s7ok4uw	651	11	been	be	VBN
cord-001835-0s7ok4uw	651	12	used	use	VBN
cord-001835-0s7ok4uw	651	13	to	to	TO
cord-001835-0s7ok4uw	651	14	model	model	VB
cord-001835-0s7ok4uw	651	15	amyloid	amyloid	NN
cord-001835-0s7ok4uw	651	16	protofibril	protofibril	NNP
cord-001835-0s7ok4uw	651	17	,	,	,
cord-001835-0s7ok4uw	651	18	and	and	CC
cord-001835-0s7ok4uw	651	19	the	the	DT
cord-001835-0s7ok4uw	651	20	two	two	CD
cord-001835-0s7ok4uw	651	21	protofibril	protofibril	NN
cord-001835-0s7ok4uw	651	22	ends	end	NNS
cord-001835-0s7ok4uw	651	23	have	have	VBP
cord-001835-0s7ok4uw	651	24	been	be	VBN
cord-001835-0s7ok4uw	651	25	investigated	investigate	VBN
cord-001835-0s7ok4uw	651	26	as	as	IN
cord-001835-0s7ok4uw	651	27	putative	putative	JJ
cord-001835-0s7ok4uw	651	28	binding	binding	NN
cord-001835-0s7ok4uw	651	29	sites	site	NNS
cord-001835-0s7ok4uw	651	30	.	.	.
cord-001835-0s7ok4uw	652	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	652	2	simulations	simulation	NNS
cord-001835-0s7ok4uw	652	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	652	4	that	that	IN
cord-001835-0s7ok4uw	652	5	the	the	DT
cord-001835-0s7ok4uw	652	6	interaction	interaction	NN
cord-001835-0s7ok4uw	652	7	with	with	IN
cord-001835-0s7ok4uw	652	8	the	the	DT
cord-001835-0s7ok4uw	652	9	two	two	CD
cord-001835-0s7ok4uw	652	10	protofibril	protofibril	NN
cord-001835-0s7ok4uw	652	11	ends	end	VBZ
cord-001835-0s7ok4uw	652	12	occurs	occur	VBZ
cord-001835-0s7ok4uw	652	13	through	through	IN
cord-001835-0s7ok4uw	652	14	different	different	JJ
cord-001835-0s7ok4uw	652	15	binding	binding	NN
cord-001835-0s7ok4uw	652	16	modes	mode	NNS
cord-001835-0s7ok4uw	652	17	.	.	.
cord-001835-0s7ok4uw	653	1	In	in	IN
cord-001835-0s7ok4uw	653	2	particular	particular	JJ
cord-001835-0s7ok4uw	653	3	,	,	,
cord-001835-0s7ok4uw	653	4	binding	bind	VBG
cord-001835-0s7ok4uw	653	5	on	on	IN
cord-001835-0s7ok4uw	653	6	the	the	DT
cord-001835-0s7ok4uw	653	7	odd	odd	JJ
cord-001835-0s7ok4uw	653	8	edge	edge	NN
cord-001835-0s7ok4uw	653	9	(	(	-LRB-
cord-001835-0s7ok4uw	653	10	chain	chain	NN
cord-001835-0s7ok4uw	653	11	A	a	NN
cord-001835-0s7ok4uw	653	12	)	)	-RRB-
cord-001835-0s7ok4uw	653	13	is	be	VBZ
cord-001835-0s7ok4uw	653	14	guided	guide	VBN
cord-001835-0s7ok4uw	653	15	by	by	IN
cord-001835-0s7ok4uw	653	16	a	a	DT
cord-001835-0s7ok4uw	653	17	well	well	RB
cord-001835-0s7ok4uw	653	18	defined	define	VBN
cord-001835-0s7ok4uw	653	19	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	653	20	cleft	cleft	NN
cord-001835-0s7ok4uw	653	21	,	,	,
cord-001835-0s7ok4uw	653	22	which	which	WDT
cord-001835-0s7ok4uw	653	23	is	be	VBZ
cord-001835-0s7ok4uw	653	24	common	common	JJ
cord-001835-0s7ok4uw	653	25	to	to	IN
cord-001835-0s7ok4uw	653	26	both	both	DT
cord-001835-0s7ok4uw	653	27	ligands	ligand	NNS
cord-001835-0s7ok4uw	653	28	(	(	-LRB-
cord-001835-0s7ok4uw	653	29	ThCT	thct	NN
cord-001835-0s7ok4uw	653	30	and	and	CC
cord-001835-0s7ok4uw	653	31	ThNT	ThNT	NNP
cord-001835-0s7ok4uw	653	32	)	)	-RRB-
cord-001835-0s7ok4uw	653	33	.	.	.
cord-001835-0s7ok4uw	654	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	654	2	,	,	,
cord-001835-0s7ok4uw	654	3	targeting	target	VBG
cord-001835-0s7ok4uw	654	4	chain	chain	NN
cord-001835-0s7ok4uw	654	5	A	A	NNP
cord-001835-0s7ok4uw	654	6	entails	entail	VBZ
cord-001835-0s7ok4uw	654	7	a	a	DT
cord-001835-0s7ok4uw	654	8	significant	significant	JJ
cord-001835-0s7ok4uw	654	9	structure	structure	NN
cord-001835-0s7ok4uw	654	10	destabilization	destabilization	NN
cord-001835-0s7ok4uw	654	11	leading	lead	VBG
cord-001835-0s7ok4uw	654	12	to	to	IN
cord-001835-0s7ok4uw	654	13	a	a	DT
cord-001835-0s7ok4uw	654	14	partial	partial	JJ
cord-001835-0s7ok4uw	654	15	loss	loss	NN
cord-001835-0s7ok4uw	654	16	of	of	IN
cord-001835-0s7ok4uw	654	17	b	b	NN
cord-001835-0s7ok4uw	654	18	structure	structure	NN
cord-001835-0s7ok4uw	654	19	and	and	CC
cord-001835-0s7ok4uw	654	20	is	be	VBZ
cord-001835-0s7ok4uw	654	21	an	an	DT
cord-001835-0s7ok4uw	654	22	energetically	energetically	RB
cord-001835-0s7ok4uw	654	23	favoured	favour	VBN
cord-001835-0s7ok4uw	654	24	process	process	NN
cord-001835-0s7ok4uw	654	25	,	,	,
cord-001835-0s7ok4uw	654	26	as	as	IN
cord-001835-0s7ok4uw	654	27	assessed	assess	VBN
cord-001835-0s7ok4uw	654	28	by	by	IN
cord-001835-0s7ok4uw	654	29	MM	MM	NNP
cord-001835-0s7ok4uw	654	30	/	/	SYM
cord-001835-0s7ok4uw	654	31	PBSA	PBSA	NNP
cord-001835-0s7ok4uw	654	32	calculations	calculation	NNS
cord-001835-0s7ok4uw	654	33	.	.	.
cord-001835-0s7ok4uw	655	1	A	a	DT
cord-001835-0s7ok4uw	655	2	significant	significant	JJ
cord-001835-0s7ok4uw	655	3	contribution	contribution	NN
cord-001835-0s7ok4uw	655	4	of	of	IN
cord-001835-0s7ok4uw	655	5	the	the	DT
cord-001835-0s7ok4uw	655	6	trehalose	trehalose	JJ
cord-001835-0s7ok4uw	655	7	moiety	moiety	NN
cord-001835-0s7ok4uw	655	8	to	to	IN
cord-001835-0s7ok4uw	655	9	complexes	complex	NNS
cord-001835-0s7ok4uw	655	10	stabilities	stability	NNS
cord-001835-0s7ok4uw	655	11	emerged	emerge	VBD
cord-001835-0s7ok4uw	655	12	from	from	IN
cord-001835-0s7ok4uw	655	13	our	-PRON-	PRP$
cord-001835-0s7ok4uw	655	14	results	result	NNS
cord-001835-0s7ok4uw	655	15	.	.	.
cord-001835-0s7ok4uw	656	1	The	the	DT
cord-001835-0s7ok4uw	656	2	basic	basic	JJ
cord-001835-0s7ok4uw	656	3	structural	structural	JJ
cord-001835-0s7ok4uw	656	4	unit	unit	NN
cord-001835-0s7ok4uw	656	5	of	of	IN
cord-001835-0s7ok4uw	656	6	chromatin	chromatin	NNP
cord-001835-0s7ok4uw	656	7	is	be	VBZ
cord-001835-0s7ok4uw	656	8	the	the	DT
cord-001835-0s7ok4uw	656	9	nucleosome	nucleosome	NN
cord-001835-0s7ok4uw	656	10	,	,	,
cord-001835-0s7ok4uw	656	11	which	which	WDT
cord-001835-0s7ok4uw	656	12	is	be	VBZ
cord-001835-0s7ok4uw	656	13	composed	compose	VBN
cord-001835-0s7ok4uw	656	14	of	of	IN
cord-001835-0s7ok4uw	656	15	histone	histone	NN
cord-001835-0s7ok4uw	656	16	proteins	protein	NNS
cord-001835-0s7ok4uw	656	17	forming	form	VBG
cord-001835-0s7ok4uw	656	18	a	a	DT
cord-001835-0s7ok4uw	656	19	scaffold	scaffold	NN
cord-001835-0s7ok4uw	656	20	with	with	IN
cord-001835-0s7ok4uw	656	21	about	about	RB
cord-001835-0s7ok4uw	656	22	150	150	CD
cord-001835-0s7ok4uw	656	23	base	base	NN
cord-001835-0s7ok4uw	656	24	pairs	pair	NNS
cord-001835-0s7ok4uw	656	25	of	of	IN
cord-001835-0s7ok4uw	656	26	DNA	DNA	NNP
cord-001835-0s7ok4uw	656	27	wrapped	wrap	VBN
cord-001835-0s7ok4uw	656	28	around	around	RB
cord-001835-0s7ok4uw	656	29	.	.	.
cord-001835-0s7ok4uw	657	1	Chromatin	Chromatin	NNP
cord-001835-0s7ok4uw	657	2	compacts	compact	NNS
cord-001835-0s7ok4uw	657	3	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	657	4	genomes	genome	NNS
cord-001835-0s7ok4uw	657	5	and	and	CC
cord-001835-0s7ok4uw	657	6	regulates	regulate	VBZ
cord-001835-0s7ok4uw	657	7	gene	gene	NN
cord-001835-0s7ok4uw	657	8	activity	activity	NN
cord-001835-0s7ok4uw	657	9	,	,	,
cord-001835-0s7ok4uw	657	10	which	which	WDT
cord-001835-0s7ok4uw	657	11	is	be	VBZ
cord-001835-0s7ok4uw	657	12	mediated	mediate	VBN
cord-001835-0s7ok4uw	657	13	in	in	IN
cord-001835-0s7ok4uw	657	14	part	part	NN
cord-001835-0s7ok4uw	657	15	by	by	IN
cord-001835-0s7ok4uw	657	16	posttranslational	posttranslational	JJ
cord-001835-0s7ok4uw	657	17	modifications	modification	NNS
cord-001835-0s7ok4uw	657	18	(	(	-LRB-
cord-001835-0s7ok4uw	657	19	PTMs	ptm	NNS
cord-001835-0s7ok4uw	657	20	)	)	-RRB-
cord-001835-0s7ok4uw	657	21	on	on	IN
cord-001835-0s7ok4uw	657	22	the	the	DT
cord-001835-0s7ok4uw	657	23	N	n	CD
cord-001835-0s7ok4uw	657	24	-	-	HYPH
cord-001835-0s7ok4uw	657	25	terminal	terminal	NN
cord-001835-0s7ok4uw	657	26	tails	tail	NNS
cord-001835-0s7ok4uw	657	27	of	of	IN
cord-001835-0s7ok4uw	657	28	the	the	DT
cord-001835-0s7ok4uw	657	29	histones	histone	NNS
cord-001835-0s7ok4uw	657	30	.	.	.
cord-001835-0s7ok4uw	658	1	Uncovering	uncover	VBG
cord-001835-0s7ok4uw	658	2	the	the	DT
cord-001835-0s7ok4uw	658	3	detailed	detailed	JJ
cord-001835-0s7ok4uw	658	4	relationship	relationship	NN
cord-001835-0s7ok4uw	658	5	between	between	IN
cord-001835-0s7ok4uw	658	6	histone	histone	NN
cord-001835-0s7ok4uw	658	7	tail	tail	NN
cord-001835-0s7ok4uw	658	8	modifications	modification	NNS
cord-001835-0s7ok4uw	658	9	and	and	CC
cord-001835-0s7ok4uw	658	10	gene	gene	NN
cord-001835-0s7ok4uw	658	11	activity	activity	NN
cord-001835-0s7ok4uw	658	12	is	be	VBZ
cord-001835-0s7ok4uw	658	13	a	a	DT
cord-001835-0s7ok4uw	658	14	major	major	JJ
cord-001835-0s7ok4uw	658	15	topic	topic	NN
cord-001835-0s7ok4uw	658	16	of	of	IN
cord-001835-0s7ok4uw	658	17	biomedical	biomedical	JJ
cord-001835-0s7ok4uw	658	18	sciences	sciences	NNPS
cord-001835-0s7ok4uw	658	19	and	and	CC
cord-001835-0s7ok4uw	658	20	general	general	JJ
cord-001835-0s7ok4uw	658	21	techniques	technique	NNS
cord-001835-0s7ok4uw	658	22	for	for	IN
cord-001835-0s7ok4uw	658	23	generating	generate	VBG
cord-001835-0s7ok4uw	658	24	nucleosomes	nucleosome	NNS
cord-001835-0s7ok4uw	658	25	with	with	IN
cord-001835-0s7ok4uw	658	26	defined	define	VBN
cord-001835-0s7ok4uw	658	27	modification	modification	NN
cord-001835-0s7ok4uw	658	28	patterns	pattern	NNS
cord-001835-0s7ok4uw	658	29	in	in	IN
cord-001835-0s7ok4uw	658	30	large	large	JJ
cord-001835-0s7ok4uw	658	31	numbers	number	NNS
cord-001835-0s7ok4uw	658	32	would	would	MD
cord-001835-0s7ok4uw	658	33	greatly	greatly	RB
cord-001835-0s7ok4uw	658	34	facilitate	facilitate	VB
cord-001835-0s7ok4uw	658	35	such	such	JJ
cord-001835-0s7ok4uw	658	36	investigations	investigation	NNS
cord-001835-0s7ok4uw	658	37	.	.	.
cord-001835-0s7ok4uw	659	1	To	to	IN
cord-001835-0s7ok4uw	659	2	this	this	DT
cord-001835-0s7ok4uw	659	3	end	end	NN
cord-001835-0s7ok4uw	659	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	659	5	are	be	VBP
cord-001835-0s7ok4uw	659	6	establishing	establish	VBG
cord-001835-0s7ok4uw	659	7	a	a	DT
cord-001835-0s7ok4uw	659	8	chemical	chemical	JJ
cord-001835-0s7ok4uw	659	9	toolbox	toolbox	NN
cord-001835-0s7ok4uw	659	10	for	for	IN
cord-001835-0s7ok4uw	659	11	designer	designer	NN
cord-001835-0s7ok4uw	659	12	chromatin	chromatin	NN
cord-001835-0s7ok4uw	659	13	with	with	IN
cord-001835-0s7ok4uw	659	14	defined	define	VBN
cord-001835-0s7ok4uw	659	15	histone	histone	NN
cord-001835-0s7ok4uw	659	16	PTM	PTM	NNP
cord-001835-0s7ok4uw	659	17	patterns	pattern	NNS
cord-001835-0s7ok4uw	659	18	.	.	.
cord-001835-0s7ok4uw	660	1	A	a	DT
cord-001835-0s7ok4uw	660	2	protein	protein	NN
cord-001835-0s7ok4uw	660	3	semysinthesis	semysinthesis	NN
cord-001835-0s7ok4uw	660	4	approach	approach	NN
cord-001835-0s7ok4uw	660	5	is	be	VBZ
cord-001835-0s7ok4uw	660	6	used	use	VBN
cord-001835-0s7ok4uw	660	7	that	that	IN
cord-001835-0s7ok4uw	660	8	bases	basis	NNS
cord-001835-0s7ok4uw	660	9	on	on	IN
cord-001835-0s7ok4uw	660	10	"	"	``
cord-001835-0s7ok4uw	660	11	ligation	ligation	NN
cord-001835-0s7ok4uw	660	12	-	-	HYPH
cord-001835-0s7ok4uw	660	13	ready	ready	JJ
cord-001835-0s7ok4uw	660	14	nucleosomes	nucleosome	NNS
cord-001835-0s7ok4uw	660	15	"	"	''
cord-001835-0s7ok4uw	660	16	with	with	IN
cord-001835-0s7ok4uw	660	17	truncated	truncated	JJ
cord-001835-0s7ok4uw	660	18	histone	histone	NN
cord-001835-0s7ok4uw	660	19	H3	H3	NNP
cord-001835-0s7ok4uw	660	20	that	that	WDT
cord-001835-0s7ok4uw	660	21	can	can	MD
cord-001835-0s7ok4uw	660	22	be	be	VB
cord-001835-0s7ok4uw	660	23	ligated	ligate	VBN
cord-001835-0s7ok4uw	660	24	with	with	IN
cord-001835-0s7ok4uw	660	25	the	the	DT
cord-001835-0s7ok4uw	660	26	corresponding	corresponding	JJ
cord-001835-0s7ok4uw	660	27	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	660	28	histone	histone	NN
cord-001835-0s7ok4uw	660	29	tail	tail	NN
cord-001835-0s7ok4uw	660	30	.	.	.
cord-001835-0s7ok4uw	661	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	661	2	resorted	resort	VBD
cord-001835-0s7ok4uw	661	3	to	to	IN
cord-001835-0s7ok4uw	661	4	sortase	sortase	NNP
cord-001835-0s7ok4uw	661	5	-	-	HYPH
cord-001835-0s7ok4uw	661	6	mediated	mediate	VBN
cord-001835-0s7ok4uw	661	7	ligation	ligation	NN
cord-001835-0s7ok4uw	661	8	as	as	IN
cord-001835-0s7ok4uw	661	9	chemoselective	chemoselective	JJ
cord-001835-0s7ok4uw	661	10	ligation	ligation	NN
cord-001835-0s7ok4uw	661	11	method	method	NN
cord-001835-0s7ok4uw	661	12	.	.	.
cord-001835-0s7ok4uw	662	1	Here	here	RB
cord-001835-0s7ok4uw	662	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	662	3	report	report	VBP
cord-001835-0s7ok4uw	662	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	662	5	recent	recent	JJ
cord-001835-0s7ok4uw	662	6	developments	development	NNS
cord-001835-0s7ok4uw	662	7	in	in	IN
cord-001835-0s7ok4uw	662	8	establishing	establish	VBG
cord-001835-0s7ok4uw	662	9	the	the	DT
cord-001835-0s7ok4uw	662	10	envisioned	envision	VBN
cord-001835-0s7ok4uw	662	11	chemical	chemical	JJ
cord-001835-0s7ok4uw	662	12	toolbox	toolbox	NN
cord-001835-0s7ok4uw	662	13	for	for	IN
cord-001835-0s7ok4uw	662	14	designer	designer	NN
cord-001835-0s7ok4uw	662	15	chromatin	chromatin	NN
cord-001835-0s7ok4uw	662	16	.	.	.
cord-001835-0s7ok4uw	663	1	Evaluating	evaluate	VBG
cord-001835-0s7ok4uw	663	2	cation	cation	NN
cord-001835-0s7ok4uw	663	3	-	-	HYPH
cord-001835-0s7ok4uw	663	4	pi	pi	NN
cord-001835-0s7ok4uw	663	5	and	and	CC
cord-001835-0s7ok4uw	663	6	pi	pi	NN
cord-001835-0s7ok4uw	663	7	-	-	HYPH
cord-001835-0s7ok4uw	663	8	pi	pi	NN
cord-001835-0s7ok4uw	663	9	interaction	interaction	NN
cord-001835-0s7ok4uw	663	10	in	in	IN
cord-001835-0s7ok4uw	663	11	proteins	protein	NNS
cord-001835-0s7ok4uw	663	12	using	use	VBG
cord-001835-0s7ok4uw	663	13	various	various	JJ
cord-001835-0s7ok4uw	663	14	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	663	15	methods	method	NNS
cord-001835-0s7ok4uw	663	16	 	 	_SP
cord-001835-0s7ok4uw	663	17	In	in	IN
cord-001835-0s7ok4uw	663	18	proteins	protein	NNS
cord-001835-0s7ok4uw	663	19	the	the	DT
cord-001835-0s7ok4uw	663	20	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	663	21	residues	residue	NNS
cord-001835-0s7ok4uw	663	22	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	663	23	(	(	-LRB-
cord-001835-0s7ok4uw	663	24	Phe	Phe	NNP
cord-001835-0s7ok4uw	663	25	)	)	-RRB-
cord-001835-0s7ok4uw	663	26	,	,	,
cord-001835-0s7ok4uw	663	27	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	663	28	(	(	-LRB-
cord-001835-0s7ok4uw	663	29	Tyr	Tyr	NNP
cord-001835-0s7ok4uw	663	30	)	)	-RRB-
cord-001835-0s7ok4uw	663	31	,	,	,
cord-001835-0s7ok4uw	663	32	and	and	CC
cord-001835-0s7ok4uw	663	33	tryptophan	tryptophan	NN
cord-001835-0s7ok4uw	663	34	(	(	-LRB-
cord-001835-0s7ok4uw	663	35	Trp	trp	NN
cord-001835-0s7ok4uw	663	36	)	)	-RRB-
cord-001835-0s7ok4uw	663	37	can	can	MD
cord-001835-0s7ok4uw	663	38	be	be	VB
cord-001835-0s7ok4uw	663	39	involved	involve	VBN
cord-001835-0s7ok4uw	663	40	in	in	IN
cord-001835-0s7ok4uw	663	41	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	663	42	interactions	interaction	NNS
cord-001835-0s7ok4uw	663	43	known	know	VBN
cord-001835-0s7ok4uw	663	44	as	as	IN
cord-001835-0s7ok4uw	663	45	cation	cation	NN
cord-001835-0s7ok4uw	663	46	-	-	HYPH
cord-001835-0s7ok4uw	663	47	pi	pi	NN
cord-001835-0s7ok4uw	663	48	and	and	CC
cord-001835-0s7ok4uw	663	49	pi	pi	NN
cord-001835-0s7ok4uw	663	50	-	-	HYPH
cord-001835-0s7ok4uw	663	51	pi	pi	NN
cord-001835-0s7ok4uw	663	52	interactions	interaction	NNS
cord-001835-0s7ok4uw	663	53	(	(	-LRB-
cord-001835-0s7ok4uw	663	54	Dougherty	Dougherty	NNP
cord-001835-0s7ok4uw	663	55	2000	2000	CD
cord-001835-0s7ok4uw	663	56	)	)	-RRB-
cord-001835-0s7ok4uw	663	57	.	.	.
cord-001835-0s7ok4uw	664	1	Compared	compare	VBN
cord-001835-0s7ok4uw	664	2	to	to	IN
cord-001835-0s7ok4uw	664	3	other	other	JJ
cord-001835-0s7ok4uw	664	4	non	non	JJ
cord-001835-0s7ok4uw	664	5	covalent	covalent	JJ
cord-001835-0s7ok4uw	664	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	664	7	in	in	IN
cord-001835-0s7ok4uw	664	8	proteins	protein	NNS
cord-001835-0s7ok4uw	664	9	,	,	,
cord-001835-0s7ok4uw	664	10	like	like	IN
cord-001835-0s7ok4uw	664	11	H	h	NN
cord-001835-0s7ok4uw	664	12	-	-	HYPH
cord-001835-0s7ok4uw	664	13	bonds	bond	NNS
cord-001835-0s7ok4uw	664	14	,	,	,
cord-001835-0s7ok4uw	664	15	dipole	dipole	NN
cord-001835-0s7ok4uw	664	16	-	-	HYPH
cord-001835-0s7ok4uw	664	17	dipole	dipole	NN
cord-001835-0s7ok4uw	664	18	,	,	,
cord-001835-0s7ok4uw	664	19	or	or	CC
cord-001835-0s7ok4uw	664	20	van	van	NNP
cord-001835-0s7ok4uw	664	21	der	der	NNP
cord-001835-0s7ok4uw	664	22	Waals	Waals	NNP
cord-001835-0s7ok4uw	664	23	interactions	interaction	NNS
cord-001835-0s7ok4uw	664	24	,	,	,
cord-001835-0s7ok4uw	664	25	relatively	relatively	RB
cord-001835-0s7ok4uw	664	26	little	little	JJ
cord-001835-0s7ok4uw	664	27	is	be	VBZ
cord-001835-0s7ok4uw	664	28	known	know	VBN
cord-001835-0s7ok4uw	664	29	about	about	IN
cord-001835-0s7ok4uw	664	30	the	the	DT
cord-001835-0s7ok4uw	664	31	pi	pi	NN
cord-001835-0s7ok4uw	664	32	-	-	HYPH
cord-001835-0s7ok4uw	664	33	pi	pi	NN
cord-001835-0s7ok4uw	664	34	and	and	CC
cord-001835-0s7ok4uw	664	35	the	the	DT
cord-001835-0s7ok4uw	664	36	cation	cation	NN
cord-001835-0s7ok4uw	664	37	-	-	HYPH
cord-001835-0s7ok4uw	664	38	pi	pi	NN
cord-001835-0s7ok4uw	664	39	interactions	interaction	NNS
cord-001835-0s7ok4uw	664	40	.	.	.
cord-001835-0s7ok4uw	665	1	The	the	DT
cord-001835-0s7ok4uw	665	2	strength	strength	NN
cord-001835-0s7ok4uw	665	3	of	of	IN
cord-001835-0s7ok4uw	665	4	both	both	DT
cord-001835-0s7ok4uw	665	5	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	665	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	665	7	is	be	VBZ
cord-001835-0s7ok4uw	665	8	dependent	dependent	JJ
cord-001835-0s7ok4uw	665	9	on	on	IN
cord-001835-0s7ok4uw	665	10	the	the	DT
cord-001835-0s7ok4uw	665	11	pi	pi	NN
cord-001835-0s7ok4uw	665	12	-	-	HYPH
cord-001835-0s7ok4uw	665	13	electron	electron	NN
cord-001835-0s7ok4uw	665	14	density	density	NN
cord-001835-0s7ok4uw	665	15	in	in	IN
cord-001835-0s7ok4uw	665	16	the	the	DT
cord-001835-0s7ok4uw	665	17	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	665	18	residues	residue	NNS
cord-001835-0s7ok4uw	665	19	.	.	.
cord-001835-0s7ok4uw	666	1	A	a	DT
cord-001835-0s7ok4uw	666	2	lowering	lowering	NN
cord-001835-0s7ok4uw	666	3	of	of	IN
cord-001835-0s7ok4uw	666	4	electron	electron	NN
cord-001835-0s7ok4uw	666	5	density	density	NN
cord-001835-0s7ok4uw	666	6	can	can	MD
cord-001835-0s7ok4uw	666	7	be	be	VB
cord-001835-0s7ok4uw	666	8	created	create	VBN
cord-001835-0s7ok4uw	666	9	by	by	IN
cord-001835-0s7ok4uw	666	10	introducing	introduce	VBG
cord-001835-0s7ok4uw	666	11	strong	strong	JJ
cord-001835-0s7ok4uw	666	12	electron	electron	NN
cord-001835-0s7ok4uw	666	13	-	-	HYPH
cord-001835-0s7ok4uw	666	14	withdrawing	withdraw	VBG
cord-001835-0s7ok4uw	666	15	substituents	substituent	NNS
cord-001835-0s7ok4uw	666	16	like	like	IN
cord-001835-0s7ok4uw	666	17	fluorine	fluorine	NN
cord-001835-0s7ok4uw	666	18	atoms	atom	NNS
cord-001835-0s7ok4uw	666	19	in	in	IN
cord-001835-0s7ok4uw	666	20	the	the	DT
cord-001835-0s7ok4uw	666	21	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	666	22	ring	ring	NN
cord-001835-0s7ok4uw	666	23	(	(	-LRB-
cord-001835-0s7ok4uw	666	24	Dougherty	Dougherty	NNP
cord-001835-0s7ok4uw	666	25	2000	2000	CD
cord-001835-0s7ok4uw	666	26	)	)	-RRB-
cord-001835-0s7ok4uw	666	27	.	.	.
cord-001835-0s7ok4uw	667	1	In	in	IN
cord-001835-0s7ok4uw	667	2	this	this	DT
cord-001835-0s7ok4uw	667	3	way	way	NN
cord-001835-0s7ok4uw	667	4	a	a	DT
cord-001835-0s7ok4uw	667	5	nearly	nearly	RB
cord-001835-0s7ok4uw	667	6	isosteric	isosteric	JJ
cord-001835-0s7ok4uw	667	7	change	change	NN
cord-001835-0s7ok4uw	667	8	in	in	IN
cord-001835-0s7ok4uw	667	9	the	the	DT
cord-001835-0s7ok4uw	667	10	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	667	11	system	system	NN
cord-001835-0s7ok4uw	667	12	results	result	VBZ
cord-001835-0s7ok4uw	667	13	in	in	IN
cord-001835-0s7ok4uw	667	14	a	a	DT
cord-001835-0s7ok4uw	667	15	marked	marked	JJ
cord-001835-0s7ok4uw	667	16	change	change	NN
cord-001835-0s7ok4uw	667	17	in	in	IN
cord-001835-0s7ok4uw	667	18	electron	electron	NN
cord-001835-0s7ok4uw	667	19	density	density	NN
cord-001835-0s7ok4uw	667	20	.	.	.
cord-001835-0s7ok4uw	668	1	Substitution	substitution	NN
cord-001835-0s7ok4uw	668	2	with	with	IN
cord-001835-0s7ok4uw	668	3	methyl	methyl	NN
cord-001835-0s7ok4uw	668	4	groups	group	NNS
cord-001835-0s7ok4uw	668	5	is	be	VBZ
cord-001835-0s7ok4uw	668	6	known	know	VBN
cord-001835-0s7ok4uw	668	7	to	to	TO
cord-001835-0s7ok4uw	668	8	slightly	slightly	RB
cord-001835-0s7ok4uw	668	9	increase	increase	VB
cord-001835-0s7ok4uw	668	10	the	the	DT
cord-001835-0s7ok4uw	668	11	electron	electron	NN
cord-001835-0s7ok4uw	668	12	density	density	NN
cord-001835-0s7ok4uw	668	13	.	.	.
cord-001835-0s7ok4uw	669	1	The	the	DT
cord-001835-0s7ok4uw	669	2	response	response	NN
cord-001835-0s7ok4uw	669	3	to	to	IN
cord-001835-0s7ok4uw	669	4	low	low	JJ
cord-001835-0s7ok4uw	669	5	cellular	cellular	JJ
cord-001835-0s7ok4uw	669	6	oxygen	oxygen	NN
cord-001835-0s7ok4uw	669	7	levels	level	NNS
cord-001835-0s7ok4uw	669	8	in	in	IN
cord-001835-0s7ok4uw	669	9	humans	human	NNS
cord-001835-0s7ok4uw	669	10	and	and	CC
cord-001835-0s7ok4uw	669	11	other	other	JJ
cord-001835-0s7ok4uw	669	12	animals	animal	NNS
cord-001835-0s7ok4uw	669	13	is	be	VBZ
cord-001835-0s7ok4uw	669	14	induced	induce	VBN
cord-001835-0s7ok4uw	669	15	by	by	IN
cord-001835-0s7ok4uw	669	16	the	the	DT
cord-001835-0s7ok4uw	669	17	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	669	18	inducible	inducible	JJ
cord-001835-0s7ok4uw	669	19	transcription	transcription	NN
cord-001835-0s7ok4uw	669	20	factors	factor	NNS
cord-001835-0s7ok4uw	669	21	(	(	-LRB-
cord-001835-0s7ok4uw	669	22	HIFs	HIFs	NNP
cord-001835-0s7ok4uw	669	23	)	)	-RRB-
cord-001835-0s7ok4uw	669	24	.	.	.
cord-001835-0s7ok4uw	670	1	These	these	DT
cord-001835-0s7ok4uw	670	2	transcription	transcription	NN
cord-001835-0s7ok4uw	670	3	factors	factor	NNS
cord-001835-0s7ok4uw	670	4	are	be	VBP
cord-001835-0s7ok4uw	670	5	regulated	regulate	VBN
cord-001835-0s7ok4uw	670	6	by	by	IN
cord-001835-0s7ok4uw	670	7	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	670	8	inducible	inducible	JJ
cord-001835-0s7ok4uw	670	9	factor	factor	NN
cord-001835-0s7ok4uw	670	10	prolyl	prolyl	FW
cord-001835-0s7ok4uw	670	11	hydroxylases	hydroxylases	NNP
cord-001835-0s7ok4uw	670	12	(	(	-LRB-
cord-001835-0s7ok4uw	670	13	PHDs	PHDs	NNPS
cord-001835-0s7ok4uw	670	14	)	)	-RRB-
cord-001835-0s7ok4uw	670	15	,	,	,
cord-001835-0s7ok4uw	670	16	which	which	WDT
cord-001835-0s7ok4uw	670	17	act	act	VBP
cord-001835-0s7ok4uw	670	18	as	as	IN
cord-001835-0s7ok4uw	670	19	'	'	''
cord-001835-0s7ok4uw	670	20	oxygen	oxygen	NN
cord-001835-0s7ok4uw	670	21	sensors	sensor	NNS
cord-001835-0s7ok4uw	670	22	'	'	''
cord-001835-0s7ok4uw	670	23	by	by	IN
cord-001835-0s7ok4uw	670	24	hydroxylating	hydroxylating	NNP
cord-001835-0s7ok4uw	670	25	HIFs	HIFs	NNP
cord-001835-0s7ok4uw	670	26	,	,	,
cord-001835-0s7ok4uw	670	27	thus	thus	RB
cord-001835-0s7ok4uw	670	28	leading	lead	VBG
cord-001835-0s7ok4uw	670	29	to	to	IN
cord-001835-0s7ok4uw	670	30	the	the	DT
cord-001835-0s7ok4uw	670	31	proteomic	proteomic	JJ
cord-001835-0s7ok4uw	670	32	degradation	degradation	NN
cord-001835-0s7ok4uw	670	33	of	of	IN
cord-001835-0s7ok4uw	670	34	the	the	DT
cord-001835-0s7ok4uw	670	35	transcription	transcription	NN
cord-001835-0s7ok4uw	670	36	factors	factor	NNS
cord-001835-0s7ok4uw	670	37	.	.	.
cord-001835-0s7ok4uw	671	1	Over	over	IN
cord-001835-0s7ok4uw	671	2	the	the	DT
cord-001835-0s7ok4uw	671	3	last	last	JJ
cord-001835-0s7ok4uw	671	4	years	year	NNS
cord-001835-0s7ok4uw	671	5	,	,	,
cord-001835-0s7ok4uw	671	6	there	there	EX
cord-001835-0s7ok4uw	671	7	have	have	VBP
cord-001835-0s7ok4uw	671	8	been	be	VBN
cord-001835-0s7ok4uw	671	9	multiple	multiple	JJ
cord-001835-0s7ok4uw	671	10	reports	report	NNS
cord-001835-0s7ok4uw	671	11	that	that	WDT
cord-001835-0s7ok4uw	671	12	describe	describe	VBP
cord-001835-0s7ok4uw	671	13	additional	additional	JJ
cord-001835-0s7ok4uw	671	14	PHD	phd	NN
cord-001835-0s7ok4uw	671	15	substrates	substrate	NNS
cord-001835-0s7ok4uw	671	16	other	other	JJ
cord-001835-0s7ok4uw	671	17	than	than	IN
cord-001835-0s7ok4uw	671	18	HIFs	hif	NNS
cord-001835-0s7ok4uw	671	19	.	.	.
cord-001835-0s7ok4uw	672	1	Among	among	IN
cord-001835-0s7ok4uw	672	2	them	-PRON-	PRP
cord-001835-0s7ok4uw	672	3	are	be	VBP
cord-001835-0s7ok4uw	672	4	the	the	DT
cord-001835-0s7ok4uw	672	5	large	large	JJ
cord-001835-0s7ok4uw	672	6	subunit	subunit	NN
cord-001835-0s7ok4uw	672	7	of	of	IN
cord-001835-0s7ok4uw	672	8	RNA	RNA	NNP
cord-001835-0s7ok4uw	672	9	Pol	Pol	NNP
cord-001835-0s7ok4uw	672	10	II	II	NNP
cord-001835-0s7ok4uw	672	11	,	,	,
cord-001835-0s7ok4uw	672	12	several	several	JJ
cord-001835-0s7ok4uw	672	13	transcription	transcription	NN
cord-001835-0s7ok4uw	672	14	factors	factor	NNS
cord-001835-0s7ok4uw	672	15	,	,	,
cord-001835-0s7ok4uw	672	16	and	and	CC
cord-001835-0s7ok4uw	672	17	components	component	NNS
cord-001835-0s7ok4uw	672	18	of	of	IN
cord-001835-0s7ok4uw	672	19	signalling	signal	VBG
cord-001835-0s7ok4uw	672	20	pathways	pathway	NNS
cord-001835-0s7ok4uw	672	21	.	.	.
cord-001835-0s7ok4uw	673	1	Validating	validate	VBG
cord-001835-0s7ok4uw	673	2	these	these	DT
cord-001835-0s7ok4uw	673	3	reports	report	NNS
cord-001835-0s7ok4uw	673	4	is	be	VBZ
cord-001835-0s7ok4uw	673	5	of	of	IN
cord-001835-0s7ok4uw	673	6	major	major	JJ
cord-001835-0s7ok4uw	673	7	medicinal	medicinal	JJ
cord-001835-0s7ok4uw	673	8	relevance	relevance	NN
cord-001835-0s7ok4uw	673	9	given	give	VBN
cord-001835-0s7ok4uw	673	10	that	that	IN
cord-001835-0s7ok4uw	673	11	PHD	PHD	NNP
cord-001835-0s7ok4uw	673	12	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	673	13	are	be	VBP
cord-001835-0s7ok4uw	673	14	now	now	RB
cord-001835-0s7ok4uw	673	15	in	in	IN
cord-001835-0s7ok4uw	673	16	the	the	DT
cord-001835-0s7ok4uw	673	17	late	late	JJ
cord-001835-0s7ok4uw	673	18	stage	stage	NN
cord-001835-0s7ok4uw	673	19	Phase	phase	NN
cord-001835-0s7ok4uw	673	20	3	3	CD
cord-001835-0s7ok4uw	673	21	clinical	clinical	JJ
cord-001835-0s7ok4uw	673	22	trials	trial	NNS
cord-001835-0s7ok4uw	673	23	.	.	.
cord-001835-0s7ok4uw	674	1	In	in	IN
cord-001835-0s7ok4uw	674	2	order	order	NN
cord-001835-0s7ok4uw	674	3	to	to	TO
cord-001835-0s7ok4uw	674	4	investigate	investigate	VB
cord-001835-0s7ok4uw	674	5	the	the	DT
cord-001835-0s7ok4uw	674	6	selectivity	selectivity	NN
cord-001835-0s7ok4uw	674	7	of	of	IN
cord-001835-0s7ok4uw	674	8	PHDs	phd	NNS
cord-001835-0s7ok4uw	674	9	,	,	,
cord-001835-0s7ok4uw	674	10	the	the	DT
cord-001835-0s7ok4uw	674	11	reported	report	VBN
cord-001835-0s7ok4uw	674	12	proteins	protein	NNS
cord-001835-0s7ok4uw	674	13	have	have	VBP
cord-001835-0s7ok4uw	674	14	been	be	VBN
cord-001835-0s7ok4uw	674	15	tested	test	VBN
cord-001835-0s7ok4uw	674	16	as	as	IN
cord-001835-0s7ok4uw	674	17	substrates	substrate	NNS
cord-001835-0s7ok4uw	674	18	for	for	IN
cord-001835-0s7ok4uw	674	19	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	674	20	by	by	IN
cord-001835-0s7ok4uw	674	21	Mass	Mass	NNP
cord-001835-0s7ok4uw	674	22	Spectrometry	Spectrometry	NNP
cord-001835-0s7ok4uw	674	23	,	,	,
cord-001835-0s7ok4uw	674	24	and	and	CC
cord-001835-0s7ok4uw	674	25	as	as	IN
cord-001835-0s7ok4uw	674	26	binders	binder	NNS
cord-001835-0s7ok4uw	674	27	or	or	CC
cord-001835-0s7ok4uw	674	28	competitors	competitor	NNS
cord-001835-0s7ok4uw	674	29	of	of	IN
cord-001835-0s7ok4uw	674	30	the	the	DT
cord-001835-0s7ok4uw	674	31	PHDs	phd	NNS
cord-001835-0s7ok4uw	674	32	.	.	.
cord-001835-0s7ok4uw	675	1	Initial	initial	JJ
cord-001835-0s7ok4uw	675	2	work	work	NN
cord-001835-0s7ok4uw	675	3	on	on	IN
cord-001835-0s7ok4uw	675	4	peptides	peptide	NNS
cord-001835-0s7ok4uw	675	5	that	that	WDT
cord-001835-0s7ok4uw	675	6	contain	contain	VBP
cord-001835-0s7ok4uw	675	7	the	the	DT
cord-001835-0s7ok4uw	675	8	putative	putative	JJ
cord-001835-0s7ok4uw	675	9	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	675	10	sites	site	NNS
cord-001835-0s7ok4uw	675	11	has	have	VBZ
cord-001835-0s7ok4uw	675	12	indicated	indicate	VBN
cord-001835-0s7ok4uw	675	13	that	that	IN
cord-001835-0s7ok4uw	675	14	the	the	DT
cord-001835-0s7ok4uw	675	15	PHDs	phd	NNS
cord-001835-0s7ok4uw	675	16	are	be	VBP
cord-001835-0s7ok4uw	675	17	much	much	RB
cord-001835-0s7ok4uw	675	18	more	more	RBR
cord-001835-0s7ok4uw	675	19	selective	selective	JJ
cord-001835-0s7ok4uw	675	20	for	for	IN
cord-001835-0s7ok4uw	675	21	their	-PRON-	PRP$
cord-001835-0s7ok4uw	675	22	well	well	RB
cord-001835-0s7ok4uw	675	23	-	-	HYPH
cord-001835-0s7ok4uw	675	24	established	establish	VBN
cord-001835-0s7ok4uw	675	25	substrate	substrate	NN
cord-001835-0s7ok4uw	675	26	HIF	HIF	NNP
cord-001835-0s7ok4uw	675	27	.	.	.
cord-001835-0s7ok4uw	676	1	However	however	RB
cord-001835-0s7ok4uw	676	2	,	,	,
cord-001835-0s7ok4uw	676	3	in	in	IN
cord-001835-0s7ok4uw	676	4	ongoing	ongoing	JJ
cord-001835-0s7ok4uw	676	5	work	work	NN
cord-001835-0s7ok4uw	676	6	these	these	DT
cord-001835-0s7ok4uw	676	7	initial	initial	JJ
cord-001835-0s7ok4uw	676	8	results	result	NNS
cord-001835-0s7ok4uw	676	9	are	be	VBP
cord-001835-0s7ok4uw	676	10	going	go	VBG
cord-001835-0s7ok4uw	676	11	to	to	TO
cord-001835-0s7ok4uw	676	12	be	be	VB
cord-001835-0s7ok4uw	676	13	validated	validate	VBN
cord-001835-0s7ok4uw	676	14	on	on	IN
cord-001835-0s7ok4uw	676	15	protein	protein	NN
cord-001835-0s7ok4uw	676	16	level	level	NN
cord-001835-0s7ok4uw	676	17	by	by	IN
cord-001835-0s7ok4uw	676	18	co	co	NN
cord-001835-0s7ok4uw	676	19	-	-	JJ
cord-001835-0s7ok4uw	676	20	expressing	express	VBG
cord-001835-0s7ok4uw	676	21	PHDs	phd	NNS
cord-001835-0s7ok4uw	676	22	with	with	IN
cord-001835-0s7ok4uw	676	23	the	the	DT
cord-001835-0s7ok4uw	676	24	reported	report	VBN
cord-001835-0s7ok4uw	676	25	substrates	substrate	NNS
cord-001835-0s7ok4uw	676	26	.	.	.
cord-001835-0s7ok4uw	677	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	677	2	,	,	,
cord-001835-0s7ok4uw	677	3	peptides	peptide	NNS
cord-001835-0s7ok4uw	677	4	of	of	IN
cord-001835-0s7ok4uw	677	5	reported	report	VBN
cord-001835-0s7ok4uw	677	6	substrates	substrate	NNS
cord-001835-0s7ok4uw	677	7	were	be	VBD
cord-001835-0s7ok4uw	677	8	screened	screen	VBN
cord-001835-0s7ok4uw	677	9	for	for	IN
cord-001835-0s7ok4uw	677	10	their	-PRON-	PRP$
cord-001835-0s7ok4uw	677	11	ability	ability	NN
cord-001835-0s7ok4uw	677	12	to	to	TO
cord-001835-0s7ok4uw	677	13	alter	alter	VB
cord-001835-0s7ok4uw	677	14	the	the	DT
cord-001835-0s7ok4uw	677	15	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	677	16	of	of	IN
cord-001835-0s7ok4uw	677	17	HIF	HIF	NNP
cord-001835-0s7ok4uw	677	18	-	-	HYPH
cord-001835-0s7ok4uw	677	19	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	677	20	by	by	IN
cord-001835-0s7ok4uw	677	21	PHD2	PHD2	NNP
cord-001835-0s7ok4uw	677	22	.	.	.
cord-001835-0s7ok4uw	678	1	An	an	DT
cord-001835-0s7ok4uw	678	2	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	678	3	effect	effect	NN
cord-001835-0s7ok4uw	678	4	of	of	IN
cord-001835-0s7ok4uw	678	5	at	at	RB
cord-001835-0s7ok4uw	678	6	least	least	RBS
cord-001835-0s7ok4uw	678	7	two	two	CD
cord-001835-0s7ok4uw	678	8	different	different	JJ
cord-001835-0s7ok4uw	678	9	peptides	peptide	NNS
cord-001835-0s7ok4uw	678	10	on	on	IN
cord-001835-0s7ok4uw	678	11	PHD2	PHD2	NNP
cord-001835-0s7ok4uw	678	12	was	be	VBD
cord-001835-0s7ok4uw	678	13	observed	observe	VBN
cord-001835-0s7ok4uw	678	14	,	,	,
cord-001835-0s7ok4uw	678	15	suggesting	suggest	VBG
cord-001835-0s7ok4uw	678	16	that	that	IN
cord-001835-0s7ok4uw	678	17	there	there	EX
cord-001835-0s7ok4uw	678	18	is	be	VBZ
cord-001835-0s7ok4uw	678	19	an	an	DT
cord-001835-0s7ok4uw	678	20	interaction	interaction	NN
cord-001835-0s7ok4uw	678	21	between	between	IN
cord-001835-0s7ok4uw	678	22	the	the	DT
cord-001835-0s7ok4uw	678	23	prolyl	prolyl	JJ
cord-001835-0s7ok4uw	678	24	hydroxylase	hydroxylase	NN
cord-001835-0s7ok4uw	678	25	and	and	CC
cord-001835-0s7ok4uw	678	26	these	these	DT
cord-001835-0s7ok4uw	678	27	peptides	peptide	NNS
cord-001835-0s7ok4uw	678	28	.	.	.
cord-001835-0s7ok4uw	679	1	In	in	IN
cord-001835-0s7ok4uw	679	2	order	order	NN
cord-001835-0s7ok4uw	679	3	to	to	TO
cord-001835-0s7ok4uw	679	4	investigate	investigate	VB
cord-001835-0s7ok4uw	679	5	the	the	DT
cord-001835-0s7ok4uw	679	6	mode	mode	NN
cord-001835-0s7ok4uw	679	7	of	of	IN
cord-001835-0s7ok4uw	679	8	binding	binding	NN
cord-001835-0s7ok4uw	679	9	and	and	CC
cord-001835-0s7ok4uw	679	10	inhibition	inhibition	NN
cord-001835-0s7ok4uw	679	11	,	,	,
cord-001835-0s7ok4uw	679	12	NMR	NMR	NNP
cord-001835-0s7ok4uw	679	13	studies	study	NNS
cord-001835-0s7ok4uw	679	14	have	have	VBP
cord-001835-0s7ok4uw	679	15	been	be	VBN
cord-001835-0s7ok4uw	679	16	carried	carry	VBN
cord-001835-0s7ok4uw	679	17	out	out	RP
cord-001835-0s7ok4uw	679	18	and	and	CC
cord-001835-0s7ok4uw	679	19	binding	binding	NN
cord-001835-0s7ok4uw	679	20	of	of	IN
cord-001835-0s7ok4uw	679	21	the	the	DT
cord-001835-0s7ok4uw	679	22	two	two	CD
cord-001835-0s7ok4uw	679	23	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	679	24	peptides	peptide	NNS
cord-001835-0s7ok4uw	679	25	on	on	IN
cord-001835-0s7ok4uw	679	26	PHD2	PHD2	NNP
cord-001835-0s7ok4uw	679	27	has	have	VBZ
cord-001835-0s7ok4uw	679	28	been	be	VBN
cord-001835-0s7ok4uw	679	29	shown	show	VBN
cord-001835-0s7ok4uw	679	30	.	.	.
cord-001835-0s7ok4uw	680	1	Altogether	altogether	RB
cord-001835-0s7ok4uw	680	2	,	,	,
cord-001835-0s7ok4uw	680	3	these	these	DT
cord-001835-0s7ok4uw	680	4	results	result	NNS
cord-001835-0s7ok4uw	680	5	indicate	indicate	VBP
cord-001835-0s7ok4uw	680	6	that	that	IN
cord-001835-0s7ok4uw	680	7	,	,	,
cord-001835-0s7ok4uw	680	8	although	although	IN
cord-001835-0s7ok4uw	680	9	PHDs	phd	NNS
cord-001835-0s7ok4uw	680	10	might	may	MD
cord-001835-0s7ok4uw	680	11	be	be	VB
cord-001835-0s7ok4uw	680	12	more	more	RBR
cord-001835-0s7ok4uw	680	13	selective	selective	JJ
cord-001835-0s7ok4uw	680	14	for	for	IN
cord-001835-0s7ok4uw	680	15	HIF	HIF	NNP
cord-001835-0s7ok4uw	680	16	as	as	IN
cord-001835-0s7ok4uw	680	17	a	a	DT
cord-001835-0s7ok4uw	680	18	substrate	substrate	NN
cord-001835-0s7ok4uw	680	19	as	as	IN
cord-001835-0s7ok4uw	680	20	it	-PRON-	PRP
cord-001835-0s7ok4uw	680	21	was	be	VBD
cord-001835-0s7ok4uw	680	22	initially	initially	RB
cord-001835-0s7ok4uw	680	23	thought	think	VBN
cord-001835-0s7ok4uw	680	24	,	,	,
cord-001835-0s7ok4uw	680	25	the	the	DT
cord-001835-0s7ok4uw	680	26	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	680	27	activity	activity	NN
cord-001835-0s7ok4uw	680	28	of	of	IN
cord-001835-0s7ok4uw	680	29	the	the	DT
cord-001835-0s7ok4uw	680	30	prolyl	prolyl	NNP
cord-001835-0s7ok4uw	680	31	hydroxylases	hydroxylases	NNP
cord-001835-0s7ok4uw	680	32	is	be	VBZ
cord-001835-0s7ok4uw	680	33	possibly	possibly	RB
cord-001835-0s7ok4uw	680	34	influenced	influence	VBN
cord-001835-0s7ok4uw	680	35	by	by	IN
cord-001835-0s7ok4uw	680	36	a	a	DT
cord-001835-0s7ok4uw	680	37	number	number	NN
cord-001835-0s7ok4uw	680	38	of	of	IN
cord-001835-0s7ok4uw	680	39	other	other	JJ
cord-001835-0s7ok4uw	680	40	proteins	protein	NNS
cord-001835-0s7ok4uw	680	41	that	that	WDT
cord-001835-0s7ok4uw	680	42	can	can	MD
cord-001835-0s7ok4uw	680	43	directly	directly	RB
cord-001835-0s7ok4uw	680	44	bind	bind	VB
cord-001835-0s7ok4uw	680	45	to	to	IN
cord-001835-0s7ok4uw	680	46	PHDs	phd	NNS
cord-001835-0s7ok4uw	680	47	.	.	.
cord-001835-0s7ok4uw	681	1	Non	non	JJ
cord-001835-0s7ok4uw	681	2	-	-	JJ
cord-001835-0s7ok4uw	681	3	natural	natural	JJ
cord-001835-0s7ok4uw	681	4	aminoacids	aminoacid	NNS
cord-001835-0s7ok4uw	681	5	via	via	IN
cord-001835-0s7ok4uw	681	6	the	the	DT
cord-001835-0s7ok4uw	681	7	MIO	MIO	NNP
cord-001835-0s7ok4uw	681	8	-	-	HYPH
cord-001835-0s7ok4uw	681	9	enzyme	enzyme	NN
cord-001835-0s7ok4uw	681	10	toolkit	toolkit	NN
cord-001835-0s7ok4uw	681	11	Alina	Alina	NNP
cord-001835-0s7ok4uw	681	12	Filip	Filip	NNP
cord-001835-0s7ok4uw	681	13	1	1	CD
cord-001835-0s7ok4uw	681	14	,	,	,
cord-001835-0s7ok4uw	681	15	Judith	Judith	NNP
cord-001835-0s7ok4uw	681	16	H	H	NNP
cord-001835-0s7ok4uw	681	17	Bartha	Bartha	NNP
cord-001835-0s7ok4uw	681	18	-	-	HYPH
cord-001835-0s7ok4uw	681	19	V	V	NNP
cord-001835-0s7ok4uw	681	20	ari	ari	NNP
cord-001835-0s7ok4uw	681	21	1	1	CD
cord-001835-0s7ok4uw	681	22	,	,	,
cord-001835-0s7ok4uw	681	23	Gergely	Gergely	NNP
cord-001835-0s7ok4uw	681	24	B	B	NNP
cord-001835-0s7ok4uw	681	25	an	an	DT
cord-001835-0s7ok4uw	681	26	oczy	oczy	NN
cord-001835-0s7ok4uw	681	27	2	2	CD
cord-001835-0s7ok4uw	681	28	,	,	,
cord-001835-0s7ok4uw	681	29	L	l	NN
cord-001835-0s7ok4uw	681	30	aszl	aszl	NN
cord-001835-0s7ok4uw	681	31	o	o	NNP
cord-001835-0s7ok4uw	681	32	Poppe	Poppe	NNP
cord-001835-0s7ok4uw	681	33	2	2	CD
cord-001835-0s7ok4uw	681	34	,	,	,
cord-001835-0s7ok4uw	681	35	Csaba	Csaba	NNP
cord-001835-0s7ok4uw	681	36	Paizs	Paizs	NNP
cord-001835-0s7ok4uw	681	37	1	1	CD
cord-001835-0s7ok4uw	681	38	,	,	,
cord-001835-0s7ok4uw	681	39	Florin	Florin	NNP
cord-001835-0s7ok4uw	681	40	-	-	HYPH
cord-001835-0s7ok4uw	681	41	Dan	Dan	NNP
cord-001835-0s7ok4uw	681	42	Irimie	Irimie	NNP
cord-001835-0s7ok4uw	681	43	1	1	CD
cord-001835-0s7ok4uw	681	44	1	1	CD
cord-001835-0s7ok4uw	681	45	Biocatalysis	Biocatalysis	NNP
cord-001835-0s7ok4uw	681	46	and	and	CC
cord-001835-0s7ok4uw	681	47	Biotransformation	Biotransformation	NNP
cord-001835-0s7ok4uw	681	48	Research	Research	NNP
cord-001835-0s7ok4uw	681	49	Group	Group	NNP
cord-001835-0s7ok4uw	681	50	,	,	,
cord-001835-0s7ok4uw	681	51	Department	Department	NNP
cord-001835-0s7ok4uw	681	52	of	of	IN
cord-001835-0s7ok4uw	681	53	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	681	54	,	,	,
cord-001835-0s7ok4uw	681	55	UBB	UBB	NNP
cord-001835-0s7ok4uw	681	56	,	,	,
cord-001835-0s7ok4uw	681	57	2	2	CD
cord-001835-0s7ok4uw	681	58	Department	Department	NNP
cord-001835-0s7ok4uw	681	59	of	of	IN
cord-001835-0s7ok4uw	681	60	Organic	Organic	NNP
cord-001835-0s7ok4uw	681	61	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	681	62	and	and	CC
cord-001835-0s7ok4uw	681	63	Technology	Technology	NNP
cord-001835-0s7ok4uw	681	64	An	an	DT
cord-001835-0s7ok4uw	681	65	attractive	attractive	JJ
cord-001835-0s7ok4uw	681	66	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	681	67	route	route	NN
cord-001835-0s7ok4uw	681	68	to	to	IN
cord-001835-0s7ok4uw	681	69	enantiomerically	enantiomerically	RB
cord-001835-0s7ok4uw	681	70	pure	pure	JJ
cord-001835-0s7ok4uw	681	71	to	to	IN
cord-001835-0s7ok4uw	681	72	the	the	DT
cord-001835-0s7ok4uw	681	73	highly	highly	RB
cord-001835-0s7ok4uw	681	74	valuable	valuable	JJ
cord-001835-0s7ok4uw	681	75	a	a	NN
cord-001835-0s7ok4uw	681	76	-	-	HYPH
cord-001835-0s7ok4uw	681	77	or	or	CC
cord-001835-0s7ok4uw	681	78	b	b	NN
cord-001835-0s7ok4uw	681	79	-	-	HYPH
cord-001835-0s7ok4uw	681	80	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	681	81	amino	amino	NN
cord-001835-0s7ok4uw	681	82	acids	acid	NNS
cord-001835-0s7ok4uw	681	83	involves	involve	VBZ
cord-001835-0s7ok4uw	681	84	the	the	DT
cord-001835-0s7ok4uw	681	85	use	use	NN
cord-001835-0s7ok4uw	681	86	of	of	IN
cord-001835-0s7ok4uw	681	87	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	681	88	ammonia	ammonia	NN
cord-001835-0s7ok4uw	681	89	lyases	lyase	NNS
cord-001835-0s7ok4uw	681	90	(	(	-LRB-
cord-001835-0s7ok4uw	681	91	ALs	ALs	NNP
cord-001835-0s7ok4uw	681	92	)	)	-RRB-
cord-001835-0s7ok4uw	681	93	and	and	CC
cord-001835-0s7ok4uw	681	94	aminomutases	aminomutase	NNS
cord-001835-0s7ok4uw	681	95	(	(	-LRB-
cord-001835-0s7ok4uw	681	96	AMs	AMs	NNP
cord-001835-0s7ok4uw	681	97	)	)	-RRB-
cord-001835-0s7ok4uw	681	98	.	.	.
cord-001835-0s7ok4uw	682	1	All	all	PDT
cord-001835-0s7ok4uw	682	2	these	these	DT
cord-001835-0s7ok4uw	682	3	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	682	4	have	have	VBP
cord-001835-0s7ok4uw	682	5	in	in	IN
cord-001835-0s7ok4uw	682	6	common	common	JJ
cord-001835-0s7ok4uw	682	7	an	an	DT
cord-001835-0s7ok4uw	682	8	auto	auto	NN
cord-001835-0s7ok4uw	682	9	-	-	HYPH
cord-001835-0s7ok4uw	682	10	catalically	catalically	NN
cord-001835-0s7ok4uw	682	11	formed	form	VBD
cord-001835-0s7ok4uw	682	12	5-methylene-3,5-dihydroimidazole-4-one	5-methylene-3,5-dihydroimidazole-4-one	CD
cord-001835-0s7ok4uw	682	13	(	(	-LRB-
cord-001835-0s7ok4uw	682	14	MIO	MIO	NNP
cord-001835-0s7ok4uw	682	15	)	)	-RRB-
cord-001835-0s7ok4uw	682	16	electrophilic	electrophilic	JJ
cord-001835-0s7ok4uw	682	17	prosthetic	prosthetic	JJ
cord-001835-0s7ok4uw	682	18	group	group	NN
cord-001835-0s7ok4uw	682	19	,	,	,
cord-001835-0s7ok4uw	682	20	and	and	CC
cord-001835-0s7ok4uw	682	21	show	show	VBP
cord-001835-0s7ok4uw	682	22	high	high	JJ
cord-001835-0s7ok4uw	682	23	structural	structural	NN
cord-001835-0s7ok4uw	682	24	and	and	CC
cord-001835-0s7ok4uw	682	25	sequence	sequence	NN
cord-001835-0s7ok4uw	682	26	similarities	similarity	NNS
cord-001835-0s7ok4uw	682	27	.	.	.
cord-001835-0s7ok4uw	683	1	The	the	DT
cord-001835-0s7ok4uw	683	2	recent	recent	JJ
cord-001835-0s7ok4uw	683	3	advances	advance	NNS
cord-001835-0s7ok4uw	683	4	in	in	IN
cord-001835-0s7ok4uw	683	5	improving	improve	VBG
cord-001835-0s7ok4uw	683	6	the	the	DT
cord-001835-0s7ok4uw	683	7	functional	functional	JJ
cord-001835-0s7ok4uw	683	8	properties	property	NNS
cord-001835-0s7ok4uw	683	9	of	of	IN
cord-001835-0s7ok4uw	683	10	these	these	DT
cord-001835-0s7ok4uw	683	11	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	683	12	increased	increase	VBD
cord-001835-0s7ok4uw	683	13	both	both	DT
cord-001835-0s7ok4uw	683	14	their	-PRON-	PRP$
cord-001835-0s7ok4uw	683	15	biocatalytic	biocatalytic	JJ
cord-001835-0s7ok4uw	683	16	and	and	CC
cord-001835-0s7ok4uw	683	17	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	683	18	applications	application	NNS
cord-001835-0s7ok4uw	683	19	.	.	.
cord-001835-0s7ok4uw	684	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	684	2	aimed	aim	VBD
cord-001835-0s7ok4uw	684	3	to	to	TO
cord-001835-0s7ok4uw	684	4	create	create	VB
cord-001835-0s7ok4uw	684	5	a	a	DT
cord-001835-0s7ok4uw	684	6	library	library	NN
cord-001835-0s7ok4uw	684	7	of	of	IN
cord-001835-0s7ok4uw	684	8	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	684	9	MIO	MIO	NNP
cord-001835-0s7ok4uw	684	10	-	-	HYPH
cord-001835-0s7ok4uw	684	11	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	684	12	consisting	consist	VBG
cord-001835-0s7ok4uw	684	13	of	of	IN
cord-001835-0s7ok4uw	684	14	the	the	DT
cord-001835-0s7ok4uw	684	15	PALs	pal	NNS
cord-001835-0s7ok4uw	684	16	and	and	CC
cord-001835-0s7ok4uw	684	17	PAMs	pam	NNS
cord-001835-0s7ok4uw	684	18	with	with	IN
cord-001835-0s7ok4uw	684	19	large	large	JJ
cord-001835-0s7ok4uw	684	20	substrate	substrate	NN
cord-001835-0s7ok4uw	684	21	promiscuity	promiscuity	NN
cord-001835-0s7ok4uw	684	22	in	in	IN
cord-001835-0s7ok4uw	684	23	order	order	NN
cord-001835-0s7ok4uw	684	24	to	to	TO
cord-001835-0s7ok4uw	684	25	provide	provide	VB
cord-001835-0s7ok4uw	684	26	access	access	NN
cord-001835-0s7ok4uw	684	27	to	to	IN
cord-001835-0s7ok4uw	684	28	various	various	JJ
cord-001835-0s7ok4uw	684	29	non	non	JJ
cord-001835-0s7ok4uw	684	30	-	-	JJ
cord-001835-0s7ok4uw	684	31	natural	natural	JJ
cord-001835-0s7ok4uw	684	32	aminoacids	aminoacid	NNS
cord-001835-0s7ok4uw	684	33	through	through	IN
cord-001835-0s7ok4uw	684	34	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	684	35	ammonia	ammonia	NN
cord-001835-0s7ok4uw	684	36	addition	addition	NN
cord-001835-0s7ok4uw	684	37	and/or	and/or	CC
cord-001835-0s7ok4uw	684	38	ammonia	ammonia	NN
cord-001835-0s7ok4uw	684	39	elimination	elimination	NN
cord-001835-0s7ok4uw	684	40	reactions	reaction	NNS
cord-001835-0s7ok4uw	684	41	of	of	IN
cord-001835-0s7ok4uw	684	42	the	the	DT
cord-001835-0s7ok4uw	684	43	substrate	substrate	NN
cord-001835-0s7ok4uw	684	44	library	library	NN
cord-001835-0s7ok4uw	684	45	already	already	RB
cord-001835-0s7ok4uw	684	46	available	available	JJ
cord-001835-0s7ok4uw	684	47	in	in	IN
cord-001835-0s7ok4uw	684	48	our	-PRON-	PRP$
cord-001835-0s7ok4uw	684	49	researchgroup	researchgroup	NN
cord-001835-0s7ok4uw	684	50	.	.	.
cord-001835-0s7ok4uw	685	1	The	the	DT
cord-001835-0s7ok4uw	685	2	developed	developed	JJ
cord-001835-0s7ok4uw	685	3	complementary	complementary	JJ
cord-001835-0s7ok4uw	685	4	substrate	substrate	NN
cord-001835-0s7ok4uw	685	5	and	and	CC
cord-001835-0s7ok4uw	685	6	enzyme	enzyme	NN
cord-001835-0s7ok4uw	685	7	library	library	NN
cord-001835-0s7ok4uw	685	8	would	would	MD
cord-001835-0s7ok4uw	685	9	provide	provide	VB
cord-001835-0s7ok4uw	685	10	the	the	DT
cord-001835-0s7ok4uw	685	11	MIO	MIO	NNP
cord-001835-0s7ok4uw	685	12	-	-	HYPH
cord-001835-0s7ok4uw	685	13	enzyme	enzyme	NN
cord-001835-0s7ok4uw	685	14	toolkit	toolkit	NN
cord-001835-0s7ok4uw	685	15	useful	useful	JJ
cord-001835-0s7ok4uw	685	16	for	for	IN
cord-001835-0s7ok4uw	685	17	the	the	DT
cord-001835-0s7ok4uw	685	18	synthesis	synthesis	NN
cord-001835-0s7ok4uw	685	19	of	of	IN
cord-001835-0s7ok4uw	685	20	nonnatural	nonnatural	NNP
cord-001835-0s7ok4uw	685	21	aminoacids	aminoacid	NNS
cord-001835-0s7ok4uw	685	22	.	.	.
cord-001835-0s7ok4uw	686	1	The	the	DT
cord-001835-0s7ok4uw	686	2	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	686	3	gene	gene	NN
cord-001835-0s7ok4uw	686	4	of	of	IN
cord-001835-0s7ok4uw	686	5	the	the	DT
cord-001835-0s7ok4uw	686	6	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	686	7	(	(	-LRB-
cord-001835-0s7ok4uw	686	8	PcPAL	PcPAL	NNP
cord-001835-0s7ok4uw	686	9	,	,	,
cord-001835-0s7ok4uw	686	10	RtPAL	RtPAL	NNP
cord-001835-0s7ok4uw	686	11	,	,	,
cord-001835-0s7ok4uw	686	12	AvPAL	AvPAL	NNP
cord-001835-0s7ok4uw	686	13	,	,	,
cord-001835-0s7ok4uw	686	14	PaPAM	papam	ADD
cord-001835-0s7ok4uw	686	15	)	)	-RRB-
cord-001835-0s7ok4uw	686	16	were	be	VBD
cord-001835-0s7ok4uw	686	17	cloned	clone	VBN
cord-001835-0s7ok4uw	686	18	into	into	IN
cord-001835-0s7ok4uw	686	19	pET19b_J906	pET19b_J906	NNP
cord-001835-0s7ok4uw	686	20	expression	expression	NN
cord-001835-0s7ok4uw	686	21	vector	vector	NN
cord-001835-0s7ok4uw	686	22	using	use	VBG
cord-001835-0s7ok4uw	686	23	XhoI	XhoI	NNP
cord-001835-0s7ok4uw	686	24	and	and	CC
cord-001835-0s7ok4uw	686	25	Bpu1102I	Bpu1102I	NNP
cord-001835-0s7ok4uw	686	26	cloning	clone	VBG
cord-001835-0s7ok4uw	686	27	sites	site	NNS
cord-001835-0s7ok4uw	686	28	.	.	.
cord-001835-0s7ok4uw	687	1	The	the	DT
cord-001835-0s7ok4uw	687	2	plasmid	plasmid	NN
cord-001835-0s7ok4uw	687	3	DNA	dna	NN
cord-001835-0s7ok4uw	687	4	was	be	VBD
cord-001835-0s7ok4uw	687	5	transformed	transform	VBN
cord-001835-0s7ok4uw	687	6	to	to	IN
cord-001835-0s7ok4uw	687	7	several	several	JJ
cord-001835-0s7ok4uw	687	8	E.coli	E.coli	NNS
cord-001835-0s7ok4uw	687	9	host	host	NN
cord-001835-0s7ok4uw	687	10	strains	strain	NNS
cord-001835-0s7ok4uw	687	11	(	(	-LRB-
cord-001835-0s7ok4uw	687	12	Rosetta	Rosetta	NNP
cord-001835-0s7ok4uw	687	13	,	,	,
cord-001835-0s7ok4uw	687	14	BL21	BL21	NNP
cord-001835-0s7ok4uw	687	15	,	,	,
cord-001835-0s7ok4uw	687	16	Origami	Origami	NNP
cord-001835-0s7ok4uw	687	17	2	2	CD
cord-001835-0s7ok4uw	687	18	)	)	-RRB-
cord-001835-0s7ok4uw	687	19	in	in	IN
cord-001835-0s7ok4uw	687	20	order	order	NN
cord-001835-0s7ok4uw	687	21	to	to	TO
cord-001835-0s7ok4uw	687	22	optimize	optimize	VB
cord-001835-0s7ok4uw	687	23	the	the	DT
cord-001835-0s7ok4uw	687	24	expression	expression	NN
cord-001835-0s7ok4uw	687	25	yields	yield	NNS
cord-001835-0s7ok4uw	687	26	.	.	.
cord-001835-0s7ok4uw	688	1	The	the	DT
cord-001835-0s7ok4uw	688	2	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	688	3	containing	contain	VBG
cord-001835-0s7ok4uw	688	4	an	an	DT
cord-001835-0s7ok4uw	688	5	N	n	CD
cord-001835-0s7ok4uw	688	6	-	-	HYPH
cord-001835-0s7ok4uw	688	7	terminal	terminal	NN
cord-001835-0s7ok4uw	688	8	His10-tag	His10-tag	NNP
cord-001835-0s7ok4uw	688	9	were	be	VBD
cord-001835-0s7ok4uw	688	10	purified	purify	VBN
cord-001835-0s7ok4uw	688	11	with	with	IN
cord-001835-0s7ok4uw	688	12	affinity	affinity	NN
cord-001835-0s7ok4uw	688	13	chromatography	chromatography	NN
cord-001835-0s7ok4uw	688	14	,	,	,
cord-001835-0s7ok4uw	688	15	followed	follow	VBN
cord-001835-0s7ok4uw	688	16	by	by	IN
cord-001835-0s7ok4uw	688	17	ion	ion	NN
cord-001835-0s7ok4uw	688	18	-	-	HYPH
cord-001835-0s7ok4uw	688	19	exchange	exchange	NN
cord-001835-0s7ok4uw	688	20	or	or	CC
cord-001835-0s7ok4uw	688	21	/	/	SYM
cord-001835-0s7ok4uw	688	22	and	and	CC
cord-001835-0s7ok4uw	688	23	size	size	NN
cord-001835-0s7ok4uw	688	24	-	-	HYPH
cord-001835-0s7ok4uw	688	25	exclusion	exclusion	NN
cord-001835-0s7ok4uw	688	26	chromatography	chromatography	NN
cord-001835-0s7ok4uw	688	27	,	,	,
cord-001835-0s7ok4uw	688	28	obtaining	obtain	VBG
cord-001835-0s7ok4uw	688	29	pure	pure	JJ
cord-001835-0s7ok4uw	688	30	and	and	CC
cord-001835-0s7ok4uw	688	31	homogenous	homogenous	JJ
cord-001835-0s7ok4uw	688	32	proteins	protein	NNS
cord-001835-0s7ok4uw	688	33	,	,	,
cord-001835-0s7ok4uw	688	34	in	in	IN
cord-001835-0s7ok4uw	688	35	their	-PRON-	PRP$
cord-001835-0s7ok4uw	688	36	tetrameric	tetrameric	JJ
cord-001835-0s7ok4uw	688	37	,	,	,
cord-001835-0s7ok4uw	688	38	presumably	presumably	RB
cord-001835-0s7ok4uw	688	39	native	native	JJ
cord-001835-0s7ok4uw	688	40	fold	fold	NN
cord-001835-0s7ok4uw	688	41	.	.	.
cord-001835-0s7ok4uw	689	1	The	the	DT
cord-001835-0s7ok4uw	689	2	enzyme	enzyme	NN
cord-001835-0s7ok4uw	689	3	activity	activity	NN
cord-001835-0s7ok4uw	689	4	and	and	CC
cord-001835-0s7ok4uw	689	5	the	the	DT
cord-001835-0s7ok4uw	689	6	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	689	7	parameters	parameter	NNS
cord-001835-0s7ok4uw	689	8	of	of	IN
cord-001835-0s7ok4uw	689	9	the	the	DT
cord-001835-0s7ok4uw	689	10	purified	purify	VBN
cord-001835-0s7ok4uw	689	11	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	689	12	was	be	VBD
cord-001835-0s7ok4uw	689	13	determined	determine	VBN
cord-001835-0s7ok4uw	689	14	towards	towards	IN
cord-001835-0s7ok4uw	689	15	the	the	DT
cord-001835-0s7ok4uw	689	16	natural	natural	JJ
cord-001835-0s7ok4uw	689	17	substrate	substrate	NN
cord-001835-0s7ok4uw	689	18	L	l	NN
cord-001835-0s7ok4uw	689	19	-	-	HYPH
cord-001835-0s7ok4uw	689	20	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	689	21	,	,	,
cord-001835-0s7ok4uw	689	22	as	as	RB
cord-001835-0s7ok4uw	689	23	well	well	RB
cord-001835-0s7ok4uw	689	24	as	as	IN
cord-001835-0s7ok4uw	689	25	towards	towards	IN
cord-001835-0s7ok4uw	689	26	novel	novel	NN
cord-001835-0s7ok4uw	689	27	bulkier	bulky	JJR
cord-001835-0s7ok4uw	689	28	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	689	29	substrates	substrate	NNS
cord-001835-0s7ok4uw	689	30	(	(	-LRB-
cord-001835-0s7ok4uw	689	31	heteroaryl	heteroaryl	NNP
cord-001835-0s7ok4uw	689	32	alanines	alanines	NNP
cord-001835-0s7ok4uw	689	33	,	,	,
cord-001835-0s7ok4uw	689	34	styryl	styryl	NNP
cord-001835-0s7ok4uw	689	35	alanines	alanines	NNP
cord-001835-0s7ok4uw	689	36	,	,	,
cord-001835-0s7ok4uw	689	37	biphenylalanines	biphenylalanines	NNP
cord-001835-0s7ok4uw	689	38	)	)	-RRB-
cord-001835-0s7ok4uw	689	39	.	.	.
cord-001835-0s7ok4uw	690	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	690	2	to	to	TO
cord-001835-0s7ok4uw	690	3	enhance	enhance	VB
cord-001835-0s7ok4uw	690	4	their	-PRON-	PRP$
cord-001835-0s7ok4uw	690	5	biocatalytic	biocatalytic	JJ
cord-001835-0s7ok4uw	690	6	applicability	applicability	NN
cord-001835-0s7ok4uw	690	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	690	8	covalently	covalently	RB
cord-001835-0s7ok4uw	690	9	immobilized	immobilize	VBD
cord-001835-0s7ok4uw	690	10	the	the	DT
cord-001835-0s7ok4uw	690	11	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	690	12	to	to	IN
cord-001835-0s7ok4uw	690	13	carboxylated	carboxylate	VBN
cord-001835-0s7ok4uw	690	14	single	single	JJ
cord-001835-0s7ok4uw	690	15	-	-	HYPH
cord-001835-0s7ok4uw	690	16	walled	walled	JJ
cord-001835-0s7ok4uw	690	17	carbon	carbon	NN
cord-001835-0s7ok4uw	690	18	nanotubes	nanotube	NNS
cord-001835-0s7ok4uw	690	19	(	(	-LRB-
cord-001835-0s7ok4uw	690	20	SwCNT	SwCNT	NNP
cord-001835-0s7ok4uw	690	21	COOH	COOH	NNP
cord-001835-0s7ok4uw	690	22	)	)	-RRB-
cord-001835-0s7ok4uw	690	23	using	use	VBG
cord-001835-0s7ok4uw	690	24	linkers	linker	NNS
cord-001835-0s7ok4uw	690	25	with	with	IN
cord-001835-0s7ok4uw	690	26	different	different	JJ
cord-001835-0s7ok4uw	690	27	lengths	length	NNS
cord-001835-0s7ok4uw	690	28	,	,	,
cord-001835-0s7ok4uw	690	29	and	and	CC
cord-001835-0s7ok4uw	690	30	tested	test	VBD
cord-001835-0s7ok4uw	690	31	the	the	DT
cord-001835-0s7ok4uw	690	32	activity	activity	NN
cord-001835-0s7ok4uw	690	33	and	and	CC
cord-001835-0s7ok4uw	690	34	recycling	recycling	NN
cord-001835-0s7ok4uw	690	35	of	of	IN
cord-001835-0s7ok4uw	690	36	the	the	DT
cord-001835-0s7ok4uw	690	37	immobilized	immobilized	JJ
cord-001835-0s7ok4uw	690	38	enzyme	enzyme	NN
cord-001835-0s7ok4uw	690	39	.	.	.
cord-001835-0s7ok4uw	691	1	Antibodies	antibody	NNS
cord-001835-0s7ok4uw	691	2	that	that	WDT
cord-001835-0s7ok4uw	691	3	bind	bind	VBP
cord-001835-0s7ok4uw	691	4	protein	protein	NN
cord-001835-0s7ok4uw	691	5	antigens	antigen	NNS
cord-001835-0s7ok4uw	691	6	are	be	VBP
cord-001835-0s7ok4uw	691	7	indispensable	indispensable	JJ
cord-001835-0s7ok4uw	691	8	tools	tool	NNS
cord-001835-0s7ok4uw	691	9	in	in	IN
cord-001835-0s7ok4uw	691	10	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	691	11	research	research	NN
cord-001835-0s7ok4uw	691	12	and	and	CC
cord-001835-0s7ok4uw	691	13	modern	modern	JJ
cord-001835-0s7ok4uw	691	14	medicine	medicine	NN
cord-001835-0s7ok4uw	691	15	.	.	.
cord-001835-0s7ok4uw	692	1	Utilizing	utilize	VBG
cord-001835-0s7ok4uw	692	2	a	a	DT
cord-001835-0s7ok4uw	692	3	phage	phage	NN
cord-001835-0s7ok4uw	692	4	display	display	NN
cord-001835-0s7ok4uw	692	5	selection	selection	NN
cord-001835-0s7ok4uw	692	6	strategy	strategy	NN
cord-001835-0s7ok4uw	692	7	,	,	,
cord-001835-0s7ok4uw	692	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	692	9	have	have	VBP
cord-001835-0s7ok4uw	692	10	obtained	obtain	VBN
cord-001835-0s7ok4uw	692	11	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	692	12	antigen	antigen	NN
cord-001835-0s7ok4uw	692	13	binders	binder	NNS
cord-001835-0s7ok4uw	692	14	(	(	-LRB-
cord-001835-0s7ok4uw	692	15	sABs	sABs	NNP
cord-001835-0s7ok4uw	692	16	)	)	-RRB-
cord-001835-0s7ok4uw	692	17	,	,	,
cord-001835-0s7ok4uw	692	18	based	base	VBN
cord-001835-0s7ok4uw	692	19	on	on	IN
cord-001835-0s7ok4uw	692	20	a	a	DT
cord-001835-0s7ok4uw	692	21	Fab	Fab	NNP
cord-001835-0s7ok4uw	692	22	fragment	fragment	NN
cord-001835-0s7ok4uw	692	23	of	of	IN
cord-001835-0s7ok4uw	692	24	IgG	IgG	NNP
cord-001835-0s7ok4uw	692	25	,	,	,
cord-001835-0s7ok4uw	692	26	to	to	IN
cord-001835-0s7ok4uw	692	27	a	a	DT
cord-001835-0s7ok4uw	692	28	wide	wide	JJ
cord-001835-0s7ok4uw	692	29	array	array	NN
cord-001835-0s7ok4uw	692	30	of	of	IN
cord-001835-0s7ok4uw	692	31	proteins	protein	NNS
cord-001835-0s7ok4uw	692	32	as	as	RB
cord-001835-0s7ok4uw	692	33	distinct	distinct	JJ
cord-001835-0s7ok4uw	692	34	as	as	IN
cord-001835-0s7ok4uw	692	35	membrane	membrane	NN
cord-001835-0s7ok4uw	692	36	proteins	protein	NNS
cord-001835-0s7ok4uw	692	37	,	,	,
cord-001835-0s7ok4uw	692	38	structural	structural	JJ
cord-001835-0s7ok4uw	692	39	proteins	protein	NNS
cord-001835-0s7ok4uw	692	40	,	,	,
cord-001835-0s7ok4uw	692	41	scaffold	scaffold	NN
cord-001835-0s7ok4uw	692	42	proteins	protein	NNS
cord-001835-0s7ok4uw	692	43	and	and	CC
cord-001835-0s7ok4uw	692	44	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	692	45	targets	target	NNS
cord-001835-0s7ok4uw	692	46	.	.	.
cord-001835-0s7ok4uw	693	1	Here	here	RB
cord-001835-0s7ok4uw	693	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	693	3	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	693	4	the	the	DT
cord-001835-0s7ok4uw	693	5	applicability	applicability	NN
cord-001835-0s7ok4uw	693	6	of	of	IN
cord-001835-0s7ok4uw	693	7	the	the	DT
cord-001835-0s7ok4uw	693	8	sABs	sabs	NN
cord-001835-0s7ok4uw	693	9	towards	towards	IN
cord-001835-0s7ok4uw	693	10	the	the	DT
cord-001835-0s7ok4uw	693	11	native	native	JJ
cord-001835-0s7ok4uw	693	12	,	,	,
cord-001835-0s7ok4uw	693	13	full	full	JJ
cord-001835-0s7ok4uw	693	14	-	-	HYPH
cord-001835-0s7ok4uw	693	15	length	length	NN
cord-001835-0s7ok4uw	693	16	proteins	protein	NNS
cord-001835-0s7ok4uw	693	17	in	in	IN
cord-001835-0s7ok4uw	693	18	cells	cell	NNS
cord-001835-0s7ok4uw	693	19	.	.	.
cord-001835-0s7ok4uw	694	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	694	2	show	show	VBP
cord-001835-0s7ok4uw	694	3	that	that	IN
cord-001835-0s7ok4uw	694	4	the	the	DT
cord-001835-0s7ok4uw	694	5	generated	generate	VBN
cord-001835-0s7ok4uw	694	6	sABs	sabs	NN
cord-001835-0s7ok4uw	694	7	are	be	VBP
cord-001835-0s7ok4uw	694	8	able	able	JJ
cord-001835-0s7ok4uw	694	9	to	to	TO
cord-001835-0s7ok4uw	694	10	pull	pull	VB
cord-001835-0s7ok4uw	694	11	-	-	HYPH
cord-001835-0s7ok4uw	694	12	down	down	RP
cord-001835-0s7ok4uw	694	13	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	694	14	proteins	protein	NNS
cord-001835-0s7ok4uw	694	15	from	from	IN
cord-001835-0s7ok4uw	694	16	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	694	17	cell	cell	NN
cord-001835-0s7ok4uw	694	18	extracts	extract	NNS
cord-001835-0s7ok4uw	694	19	along	along	IN
cord-001835-0s7ok4uw	694	20	with	with	IN
cord-001835-0s7ok4uw	694	21	their	-PRON-	PRP$
cord-001835-0s7ok4uw	694	22	natural	natural	JJ
cord-001835-0s7ok4uw	694	23	binding	bind	VBG
cord-001835-0s7ok4uw	694	24	partners	partner	NNS
cord-001835-0s7ok4uw	694	25	.	.	.
cord-001835-0s7ok4uw	695	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	695	2	developed	develop	VBD
cord-001835-0s7ok4uw	695	3	a	a	DT
cord-001835-0s7ok4uw	695	4	method	method	NN
cord-001835-0s7ok4uw	695	5	of	of	IN
cord-001835-0s7ok4uw	695	6	utilizing	utilize	VBG
cord-001835-0s7ok4uw	695	7	our	-PRON-	PRP$
cord-001835-0s7ok4uw	695	8	high	high	JJ
cord-001835-0s7ok4uw	695	9	affinity	affinity	NN
cord-001835-0s7ok4uw	695	10	and	and	CC
cord-001835-0s7ok4uw	695	11	specificity	specificity	NN
cord-001835-0s7ok4uw	695	12	binders	binder	NNS
cord-001835-0s7ok4uw	695	13	as	as	RB
cord-001835-0s7ok4uw	695	14	fluorescently	fluorescently	RB
cord-001835-0s7ok4uw	695	15	labeled	label	VBN
cord-001835-0s7ok4uw	695	16	tools	tool	NNS
cord-001835-0s7ok4uw	695	17	to	to	TO
cord-001835-0s7ok4uw	695	18	visualize	visualize	VB
cord-001835-0s7ok4uw	695	19	target	target	NN
cord-001835-0s7ok4uw	695	20	proteins	protein	NNS
cord-001835-0s7ok4uw	695	21	in	in	IN
cord-001835-0s7ok4uw	695	22	their	-PRON-	PRP$
cord-001835-0s7ok4uw	695	23	native	native	JJ
cord-001835-0s7ok4uw	695	24	environment	environment	NN
cord-001835-0s7ok4uw	695	25	in	in	IN
cord-001835-0s7ok4uw	695	26	the	the	DT
cord-001835-0s7ok4uw	695	27	cells	cell	NNS
cord-001835-0s7ok4uw	695	28	without	without	IN
cord-001835-0s7ok4uw	695	29	the	the	DT
cord-001835-0s7ok4uw	695	30	need	need	NN
cord-001835-0s7ok4uw	695	31	of	of	IN
cord-001835-0s7ok4uw	695	32	secondary	secondary	JJ
cord-001835-0s7ok4uw	695	33	antibodies	antibody	NNS
cord-001835-0s7ok4uw	695	34	or	or	CC
cord-001835-0s7ok4uw	695	35	blocking	block	VBG
cord-001835-0s7ok4uw	695	36	reagents	reagent	NNS
cord-001835-0s7ok4uw	695	37	.	.	.
cord-001835-0s7ok4uw	696	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	696	2	system	system	NN
cord-001835-0s7ok4uw	696	3	also	also	RB
cord-001835-0s7ok4uw	696	4	includes	include	VBZ
cord-001835-0s7ok4uw	696	5	a	a	DT
cord-001835-0s7ok4uw	696	6	method	method	NN
cord-001835-0s7ok4uw	696	7	of	of	IN
cord-001835-0s7ok4uw	696	8	efficient	efficient	JJ
cord-001835-0s7ok4uw	696	9	delivery	delivery	NN
cord-001835-0s7ok4uw	696	10	of	of	IN
cord-001835-0s7ok4uw	696	11	generated	generate	VBN
cord-001835-0s7ok4uw	696	12	antibodies	antibody	NNS
cord-001835-0s7ok4uw	696	13	to	to	IN
cord-001835-0s7ok4uw	696	14	living	living	NN
cord-001835-0s7ok4uw	696	15	cells	cell	NNS
cord-001835-0s7ok4uw	696	16	,	,	,
cord-001835-0s7ok4uw	696	17	where	where	WRB
cord-001835-0s7ok4uw	696	18	they	-PRON-	PRP
cord-001835-0s7ok4uw	696	19	can	can	MD
cord-001835-0s7ok4uw	696	20	perform	perform	VB
cord-001835-0s7ok4uw	696	21	their	-PRON-	PRP$
cord-001835-0s7ok4uw	696	22	function	function	NN
cord-001835-0s7ok4uw	696	23	.	.	.
cord-001835-0s7ok4uw	697	1	The	the	DT
cord-001835-0s7ok4uw	697	2	sABs	sabs	NN
cord-001835-0s7ok4uw	697	3	have	have	VBP
cord-001835-0s7ok4uw	697	4	been	be	VBN
cord-001835-0s7ok4uw	697	5	successfully	successfully	RB
cord-001835-0s7ok4uw	697	6	used	use	VBN
cord-001835-0s7ok4uw	697	7	for	for	IN
cord-001835-0s7ok4uw	697	8	altering	alter	VBG
cord-001835-0s7ok4uw	697	9	biological	biological	JJ
cord-001835-0s7ok4uw	697	10	processes	process	NNS
cord-001835-0s7ok4uw	697	11	in	in	IN
cord-001835-0s7ok4uw	697	12	a	a	DT
cord-001835-0s7ok4uw	697	13	controllable	controllable	JJ
cord-001835-0s7ok4uw	697	14	manner	manner	NN
cord-001835-0s7ok4uw	697	15	.	.	.
cord-001835-0s7ok4uw	698	1	In	in	IN
cord-001835-0s7ok4uw	698	2	vitro	vitro	FW
cord-001835-0s7ok4uw	698	3	evolution	evolution	NN
cord-001835-0s7ok4uw	698	4	from	from	IN
cord-001835-0s7ok4uw	698	5	pluripotent	pluripotent	JJ
cord-001835-0s7ok4uw	698	6	peptide	peptide	JJ
cord-001835-0s7ok4uw	698	7	libraries	library	NNS
cord-001835-0s7ok4uw	698	8	with	with	IN
cord-001835-0s7ok4uw	698	9	natural	natural	JJ
cord-001835-0s7ok4uw	698	10	neurotoxin	neurotoxin	NN
cord-001835-0s7ok4uw	698	11	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	698	12	to	to	TO
cord-001835-0s7ok4uw	698	13	target	target	VB
cord-001835-0s7ok4uw	698	14	receptors	receptor	NNS
cord-001835-0s7ok4uw	698	15	,	,	,
cord-001835-0s7ok4uw	698	16	proteases	protease	NNS
cord-001835-0s7ok4uw	698	17	and	and	CC
cord-001835-0s7ok4uw	698	18	trophic	trophic	NN
cord-001835-0s7ok4uw	698	19	factors	factor	NNS
cord-001835-0s7ok4uw	698	20	Tai	Tai	NNP
cord-001835-0s7ok4uw	698	21	Kubo	Kubo	NNP
cord-001835-0s7ok4uw	698	22	1	1	CD
cord-001835-0s7ok4uw	698	23	,	,	,
cord-001835-0s7ok4uw	698	24	Mohammed	Mohammed	NNP
cord-001835-0s7ok4uw	698	25	Naimuddin	Naimuddin	NNP
cord-001835-0s7ok4uw	698	26	1	1	CD
cord-001835-0s7ok4uw	698	27	,	,	,
cord-001835-0s7ok4uw	698	28	Seigo	Seigo	NNP
cord-001835-0s7ok4uw	698	29	Ono	Ono	NNP
cord-001835-0s7ok4uw	698	30	1	1	CD
cord-001835-0s7ok4uw	698	31	1	1	CD
cord-001835-0s7ok4uw	698	32	National	National	NNP
cord-001835-0s7ok4uw	698	33	Institute	Institute	NNP
cord-001835-0s7ok4uw	698	34	of	of	IN
cord-001835-0s7ok4uw	698	35	Advanced	Advanced	NNP
cord-001835-0s7ok4uw	698	36	Industrial	Industrial	NNP
cord-001835-0s7ok4uw	698	37	Science	Science	NNP
cord-001835-0s7ok4uw	698	38	and	and	CC
cord-001835-0s7ok4uw	698	39	Technology	Technology	NNP
cord-001835-0s7ok4uw	698	40	(	(	-LRB-
cord-001835-0s7ok4uw	698	41	AIST	AIST	NNP
cord-001835-0s7ok4uw	698	42	)	)	-RRB-
cord-001835-0s7ok4uw	699	1	In	in	IN
cord-001835-0s7ok4uw	699	2	vitro	vitro	FW
cord-001835-0s7ok4uw	699	3	evolution	evolution	NN
cord-001835-0s7ok4uw	699	4	from	from	IN
cord-001835-0s7ok4uw	699	5	pluripotent	pluripotent	JJ
cord-001835-0s7ok4uw	699	6	peptide	peptide	JJ
cord-001835-0s7ok4uw	699	7	libraries	library	NNS
cord-001835-0s7ok4uw	699	8	with	with	IN
cord-001835-0s7ok4uw	699	9	natural	natural	JJ
cord-001835-0s7ok4uw	699	10	neurotoxin	neurotoxin	NN
cord-001835-0s7ok4uw	699	11	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	699	12	to	to	TO
cord-001835-0s7ok4uw	699	13	target	target	VB
cord-001835-0s7ok4uw	699	14	receptors	receptor	NNS
cord-001835-0s7ok4uw	699	15	,	,	,
cord-001835-0s7ok4uw	699	16	proteases	protease	NNS
cord-001835-0s7ok4uw	699	17	and	and	CC
cord-001835-0s7ok4uw	699	18	trophic	trophic	NN
cord-001835-0s7ok4uw	699	19	factors	factor	NNS
cord-001835-0s7ok4uw	699	20	Small	small	JJ
cord-001835-0s7ok4uw	699	21	molecule	molecule	NN
cord-001835-0s7ok4uw	699	22	natural	natural	JJ
cord-001835-0s7ok4uw	699	23	products	product	NNS
cord-001835-0s7ok4uw	699	24	are	be	VBP
cord-001835-0s7ok4uw	699	25	precious	precious	JJ
cord-001835-0s7ok4uw	699	26	resources	resource	NNS
cord-001835-0s7ok4uw	699	27	for	for	IN
cord-001835-0s7ok4uw	699	28	drug	drug	NN
cord-001835-0s7ok4uw	699	29	discovery	discovery	NN
cord-001835-0s7ok4uw	699	30	.	.	.
cord-001835-0s7ok4uw	700	1	During	during	IN
cord-001835-0s7ok4uw	700	2	millions	million	NNS
cord-001835-0s7ok4uw	700	3	of	of	IN
cord-001835-0s7ok4uw	700	4	years	year	NNS
cord-001835-0s7ok4uw	700	5	of	of	IN
cord-001835-0s7ok4uw	700	6	evolution	evolution	NN
cord-001835-0s7ok4uw	700	7	,	,	,
cord-001835-0s7ok4uw	700	8	natural	natural	JJ
cord-001835-0s7ok4uw	700	9	products	product	NNS
cord-001835-0s7ok4uw	700	10	must	must	MD
cord-001835-0s7ok4uw	700	11	have	have	VB
cord-001835-0s7ok4uw	700	12	been	be	VBN
cord-001835-0s7ok4uw	700	13	exposed	expose	VBN
cord-001835-0s7ok4uw	700	14	to	to	IN
cord-001835-0s7ok4uw	700	15	various	various	JJ
cord-001835-0s7ok4uw	700	16	selection	selection	NN
cord-001835-0s7ok4uw	700	17	pressures	pressure	NNS
cord-001835-0s7ok4uw	700	18	and	and	CC
cord-001835-0s7ok4uw	700	19	have	have	VBP
cord-001835-0s7ok4uw	700	20	been	be	VBN
cord-001835-0s7ok4uw	700	21	refined	refine	VBN
cord-001835-0s7ok4uw	700	22	in	in	IN
cord-001835-0s7ok4uw	700	23	structure	structure	NN
cord-001835-0s7ok4uw	700	24	and	and	CC
cord-001835-0s7ok4uw	700	25	function	function	NN
cord-001835-0s7ok4uw	700	26	to	to	TO
cord-001835-0s7ok4uw	700	27	obtain	obtain	VB
cord-001835-0s7ok4uw	700	28	the	the	DT
cord-001835-0s7ok4uw	700	29	present	present	JJ
cord-001835-0s7ok4uw	700	30	features	feature	NNS
cord-001835-0s7ok4uw	700	31	.	.	.
cord-001835-0s7ok4uw	701	1	In	in	IN
cord-001835-0s7ok4uw	701	2	some	some	DT
cord-001835-0s7ok4uw	701	3	peptide	peptide	NN
cord-001835-0s7ok4uw	701	4	neurotoxins	neurotoxin	NNS
cord-001835-0s7ok4uw	701	5	,	,	,
cord-001835-0s7ok4uw	701	6	however	however	RB
cord-001835-0s7ok4uw	701	7	,	,	,
cord-001835-0s7ok4uw	701	8	the	the	DT
cord-001835-0s7ok4uw	701	9	basic	basic	JJ
cord-001835-0s7ok4uw	701	10	molecular	molecular	JJ
cord-001835-0s7ok4uw	701	11	scaffold	scaffold	NN
cord-001835-0s7ok4uw	701	12	mainly	mainly	RB
cord-001835-0s7ok4uw	701	13	configured	configure	VBN
cord-001835-0s7ok4uw	701	14	by	by	IN
cord-001835-0s7ok4uw	701	15	disulfide	disulfide	NN
cord-001835-0s7ok4uw	702	1	(	(	-LRB-
cord-001835-0s7ok4uw	702	2	S	S	NNP
cord-001835-0s7ok4uw	702	3	-	-	HYPH
cord-001835-0s7ok4uw	702	4	S	S	NNP
cord-001835-0s7ok4uw	702	5	)	)	-RRB-
cord-001835-0s7ok4uw	702	6	bridges	bridge	NNS
cord-001835-0s7ok4uw	702	7	and/or	and/or	CC
cord-001835-0s7ok4uw	703	1	alpha	alpha	NN
cord-001835-0s7ok4uw	703	2	/	/	SYM
cord-001835-0s7ok4uw	703	3	beta	beta	NN
cord-001835-0s7ok4uw	703	4	structures	structure	NNS
cord-001835-0s7ok4uw	703	5	,	,	,
cord-001835-0s7ok4uw	703	6	is	be	VBZ
cord-001835-0s7ok4uw	703	7	strictly	strictly	RB
cord-001835-0s7ok4uw	703	8	conserved	conserve	VBN
cord-001835-0s7ok4uw	703	9	within	within	IN
cord-001835-0s7ok4uw	703	10	each	each	DT
cord-001835-0s7ok4uw	703	11	family	family	NN
cord-001835-0s7ok4uw	703	12	even	even	RB
cord-001835-0s7ok4uw	703	13	under	under	IN
cord-001835-0s7ok4uw	703	14	the	the	DT
cord-001835-0s7ok4uw	703	15	evolution	evolution	NN
cord-001835-0s7ok4uw	703	16	pressure	pressure	NN
cord-001835-0s7ok4uw	703	17	.	.	.
cord-001835-0s7ok4uw	704	1	On	on	IN
cord-001835-0s7ok4uw	704	2	the	the	DT
cord-001835-0s7ok4uw	704	3	other	other	JJ
cord-001835-0s7ok4uw	704	4	hand	hand	NN
cord-001835-0s7ok4uw	704	5	the	the	DT
cord-001835-0s7ok4uw	704	6	loop	loop	NN
cord-001835-0s7ok4uw	704	7	regions	region	NNS
cord-001835-0s7ok4uw	704	8	,	,	,
cord-001835-0s7ok4uw	704	9	which	which	WDT
cord-001835-0s7ok4uw	704	10	are	be	VBP
cord-001835-0s7ok4uw	704	11	not	not	RB
cord-001835-0s7ok4uw	704	12	heavily	heavily	RB
cord-001835-0s7ok4uw	704	13	involved	involve	VBN
cord-001835-0s7ok4uw	704	14	in	in	IN
cord-001835-0s7ok4uw	704	15	scaffold	scaffold	NN
cord-001835-0s7ok4uw	704	16	formation	formation	NN
cord-001835-0s7ok4uw	704	17	,	,	,
cord-001835-0s7ok4uw	704	18	are	be	VBP
cord-001835-0s7ok4uw	704	19	highly	highly	RB
cord-001835-0s7ok4uw	704	20	diverged	diverge	VBN
cord-001835-0s7ok4uw	704	21	.	.	.
cord-001835-0s7ok4uw	705	1	This	this	DT
cord-001835-0s7ok4uw	705	2	mode	mode	NN
cord-001835-0s7ok4uw	705	3	of	of	IN
cord-001835-0s7ok4uw	705	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	705	5	evolution	evolution	NN
cord-001835-0s7ok4uw	705	6	named	name	VBN
cord-001835-0s7ok4uw	705	7	'	'	``
cord-001835-0s7ok4uw	705	8	accelerated	accelerated	JJ
cord-001835-0s7ok4uw	705	9	evolution	evolution	NN
cord-001835-0s7ok4uw	705	10	'	'	''
cord-001835-0s7ok4uw	705	11	,	,	,
cord-001835-0s7ok4uw	705	12	is	be	VBZ
cord-001835-0s7ok4uw	705	13	reasonable	reasonable	JJ
cord-001835-0s7ok4uw	705	14	to	to	TO
cord-001835-0s7ok4uw	705	15	quickly	quickly	RB
cord-001835-0s7ok4uw	705	16	adapt	adapt	VB
cord-001835-0s7ok4uw	705	17	to	to	IN
cord-001835-0s7ok4uw	705	18	the	the	DT
cord-001835-0s7ok4uw	705	19	vigorous	vigorous	JJ
cord-001835-0s7ok4uw	705	20	change	change	NN
cord-001835-0s7ok4uw	705	21	of	of	IN
cord-001835-0s7ok4uw	705	22	the	the	DT
cord-001835-0s7ok4uw	705	23	environment	environment	NN
cord-001835-0s7ok4uw	705	24	.	.	.
cord-001835-0s7ok4uw	706	1	The	the	DT
cord-001835-0s7ok4uw	706	2	evolutionally	evolutionally	RB
cord-001835-0s7ok4uw	706	3	selected	select	VBN
cord-001835-0s7ok4uw	706	4	scaffold	scaffold	NN
cord-001835-0s7ok4uw	706	5	is	be	VBZ
cord-001835-0s7ok4uw	706	6	compact	compact	JJ
cord-001835-0s7ok4uw	706	7	harboring	harbor	VBG
cord-001835-0s7ok4uw	706	8	both	both	CC
cord-001835-0s7ok4uw	706	9	rigidity	rigidity	NN
cord-001835-0s7ok4uw	706	10	and	and	CC
cord-001835-0s7ok4uw	706	11	flexibility	flexibility	NN
cord-001835-0s7ok4uw	706	12	in	in	IN
cord-001835-0s7ok4uw	706	13	nature	nature	NN
cord-001835-0s7ok4uw	706	14	,	,	,
cord-001835-0s7ok4uw	706	15	and	and	CC
cord-001835-0s7ok4uw	706	16	it	-PRON-	PRP
cord-001835-0s7ok4uw	706	17	may	may	MD
cord-001835-0s7ok4uw	706	18	support	support	VB
cord-001835-0s7ok4uw	706	19	a	a	DT
cord-001835-0s7ok4uw	706	20	topology	topology	NN
cord-001835-0s7ok4uw	706	21	appropriate	appropriate	JJ
cord-001835-0s7ok4uw	706	22	for	for	IN
cord-001835-0s7ok4uw	706	23	target	target	NN
cord-001835-0s7ok4uw	706	24	recognition	recognition	NN
cord-001835-0s7ok4uw	706	25	and	and	CC
cord-001835-0s7ok4uw	706	26	selective	selective	JJ
cord-001835-0s7ok4uw	706	27	interaction	interaction	NN
cord-001835-0s7ok4uw	706	28	.	.	.
cord-001835-0s7ok4uw	707	1	Inspired	inspire	VBN
cord-001835-0s7ok4uw	707	2	by	by	IN
cord-001835-0s7ok4uw	707	3	the	the	DT
cord-001835-0s7ok4uw	707	4	system	system	NN
cord-001835-0s7ok4uw	707	5	,	,	,
cord-001835-0s7ok4uw	707	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	707	7	designed	design	VBD
cord-001835-0s7ok4uw	707	8	random	random	JJ
cord-001835-0s7ok4uw	707	9	peptide	peptide	JJ
cord-001835-0s7ok4uw	707	10	libraries	library	NNS
cord-001835-0s7ok4uw	707	11	from	from	IN
cord-001835-0s7ok4uw	707	12	the	the	DT
cord-001835-0s7ok4uw	707	13	peptide	peptide	JJ
cord-001835-0s7ok4uw	707	14	neurotoxins	neurotoxin	NNS
cord-001835-0s7ok4uw	707	15	of	of	IN
cord-001835-0s7ok4uw	707	16	the	the	DT
cord-001835-0s7ok4uw	707	17	accelerated	accelerated	JJ
cord-001835-0s7ok4uw	707	18	evolution	evolution	NN
cord-001835-0s7ok4uw	707	19	.	.	.
cord-001835-0s7ok4uw	708	1	A	a	DT
cord-001835-0s7ok4uw	708	2	three	three	CD
cord-001835-0s7ok4uw	708	3	-	-	HYPH
cord-001835-0s7ok4uw	708	4	finger	finger	NN
cord-001835-0s7ok4uw	708	5	(	(	-LRB-
cord-001835-0s7ok4uw	708	6	3F	3F	NNP
cord-001835-0s7ok4uw	708	7	)	)	-RRB-
cord-001835-0s7ok4uw	709	1	shaped	shape	VBN
cord-001835-0s7ok4uw	709	2	snake	snake	NN
cord-001835-0s7ok4uw	709	3	neurotoxin	neurotoxin	NN
cord-001835-0s7ok4uw	709	4	consists	consist	VBZ
cord-001835-0s7ok4uw	709	5	of	of	IN
cord-001835-0s7ok4uw	709	6	huge	huge	JJ
cord-001835-0s7ok4uw	709	7	family	family	NN
cord-001835-0s7ok4uw	709	8	evolved	evolve	VBN
cord-001835-0s7ok4uw	709	9	by	by	IN
cord-001835-0s7ok4uw	709	10	accelerated	accelerated	JJ
cord-001835-0s7ok4uw	709	11	gene	gene	NN
cord-001835-0s7ok4uw	709	12	evolution	evolution	NN
cord-001835-0s7ok4uw	709	13	.	.	.
cord-001835-0s7ok4uw	710	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	710	2	prepared	prepare	VBD
cord-001835-0s7ok4uw	710	3	a	a	DT
cord-001835-0s7ok4uw	710	4	3F	3F	NNP
cord-001835-0s7ok4uw	710	5	-	-	HYPH
cord-001835-0s7ok4uw	710	6	peptide	peptide	NN
cord-001835-0s7ok4uw	710	7	library	library	NN
cord-001835-0s7ok4uw	710	8	by	by	IN
cord-001835-0s7ok4uw	710	9	introducing	introduce	VBG
cord-001835-0s7ok4uw	710	10	random	random	JJ
cord-001835-0s7ok4uw	710	11	sequences	sequence	NNS
cord-001835-0s7ok4uw	710	12	in	in	IN
cord-001835-0s7ok4uw	710	13	each	each	DT
cord-001835-0s7ok4uw	710	14	fingertip	fingertip	NN
cord-001835-0s7ok4uw	710	15	.	.	.
cord-001835-0s7ok4uw	711	1	Another	another	DT
cord-001835-0s7ok4uw	711	2	random	random	JJ
cord-001835-0s7ok4uw	711	3	peptide	peptide	NN
cord-001835-0s7ok4uw	711	4	library	library	NN
cord-001835-0s7ok4uw	711	5	with	with	IN
cord-001835-0s7ok4uw	711	6	an	an	DT
cord-001835-0s7ok4uw	711	7	ICK	ICK	NNP
cord-001835-0s7ok4uw	711	8	(	(	-LRB-
cord-001835-0s7ok4uw	711	9	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	711	10	cystine	cystine	NN
cord-001835-0s7ok4uw	711	11	knot	knot	NN
cord-001835-0s7ok4uw	711	12	)	)	-RRB-
cord-001835-0s7ok4uw	711	13	motif	motif	NN
cord-001835-0s7ok4uw	711	14	was	be	VBD
cord-001835-0s7ok4uw	711	15	prepared	prepare	VBN
cord-001835-0s7ok4uw	711	16	based	base	VBN
cord-001835-0s7ok4uw	711	17	on	on	IN
cord-001835-0s7ok4uw	711	18	a	a	DT
cord-001835-0s7ok4uw	711	19	neurotoxin	neurotoxin	NN
cord-001835-0s7ok4uw	711	20	GTx1	GTx1	NNPS
cord-001835-0s7ok4uw	711	21	-	-	:
cord-001835-0s7ok4uw	711	22	15	15	CD
cord-001835-0s7ok4uw	711	23	from	from	IN
cord-001835-0s7ok4uw	711	24	spider	spider	NN
cord-001835-0s7ok4uw	711	25	;	;	:
cord-001835-0s7ok4uw	711	26	originally	originally	RB
cord-001835-0s7ok4uw	711	27	identified	identify	VBN
cord-001835-0s7ok4uw	711	28	as	as	IN
cord-001835-0s7ok4uw	711	29	a	a	DT
cord-001835-0s7ok4uw	711	30	T	t	NN
cord-001835-0s7ok4uw	711	31	-	-	HYPH
cord-001835-0s7ok4uw	711	32	type	type	NN
cord-001835-0s7ok4uw	711	33	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	711	34	channel	channel	NN
cord-001835-0s7ok4uw	711	35	modulator	modulator	NN
cord-001835-0s7ok4uw	711	36	.	.	.
cord-001835-0s7ok4uw	712	1	Each	each	DT
cord-001835-0s7ok4uw	712	2	library	library	NN
cord-001835-0s7ok4uw	712	3	was	be	VBD
cord-001835-0s7ok4uw	712	4	subjected	subject	VBN
cord-001835-0s7ok4uw	712	5	to	to	IN
cord-001835-0s7ok4uw	712	6	in	in	IN
cord-001835-0s7ok4uw	712	7	-	-	HYPH
cord-001835-0s7ok4uw	712	8	vitro	vitro	FW
cord-001835-0s7ok4uw	712	9	evolution	evolution	NN
cord-001835-0s7ok4uw	712	10	directed	direct	VBN
cord-001835-0s7ok4uw	712	11	to	to	IN
cord-001835-0s7ok4uw	712	12	specific	specific	JJ
cord-001835-0s7ok4uw	712	13	target	target	NN
cord-001835-0s7ok4uw	712	14	molecules	molecule	NNS
cord-001835-0s7ok4uw	712	15	.	.	.
cord-001835-0s7ok4uw	713	1	For	for	IN
cord-001835-0s7ok4uw	713	2	the	the	DT
cord-001835-0s7ok4uw	713	3	3F	3F	NNP
cord-001835-0s7ok4uw	713	4	-	-	HYPH
cord-001835-0s7ok4uw	713	5	peptide	peptide	NNP
cord-001835-0s7ok4uw	713	6	library	library	NN
cord-001835-0s7ok4uw	713	7	cDNA	cdna	NN
cord-001835-0s7ok4uw	713	8	display	display	NN
cord-001835-0s7ok4uw	713	9	method	method	NN
cord-001835-0s7ok4uw	713	10	was	be	VBD
cord-001835-0s7ok4uw	713	11	applied	apply	VBN
cord-001835-0s7ok4uw	713	12	to	to	TO
cord-001835-0s7ok4uw	713	13	select	select	VB
cord-001835-0s7ok4uw	713	14	binders	binder	NNS
cord-001835-0s7ok4uw	713	15	.	.	.
cord-001835-0s7ok4uw	714	1	When	when	WRB
cord-001835-0s7ok4uw	714	2	interleukin-6	interleukin-6	NNP
cord-001835-0s7ok4uw	714	3	(	(	-LRB-
cord-001835-0s7ok4uw	714	4	IL-6	IL-6	NNP
cord-001835-0s7ok4uw	714	5	)	)	-RRB-
cord-001835-0s7ok4uw	714	6	receptors	receptor	NNS
cord-001835-0s7ok4uw	714	7	were	be	VBD
cord-001835-0s7ok4uw	714	8	targeted	target	VBN
cord-001835-0s7ok4uw	714	9	,	,	,
cord-001835-0s7ok4uw	714	10	the	the	DT
cord-001835-0s7ok4uw	714	11	selected	select	VBN
cord-001835-0s7ok4uw	714	12	3F	3F	NNP
cord-001835-0s7ok4uw	714	13	peptides	peptide	NNS
cord-001835-0s7ok4uw	714	14	showed	show	VBD
cord-001835-0s7ok4uw	714	15	binding	bind	VBG
cord-001835-0s7ok4uw	714	16	affinities	affinity	NNS
cord-001835-0s7ok4uw	714	17	(	(	-LRB-
cord-001835-0s7ok4uw	714	18	Kd	Kd	NNP
cord-001835-0s7ok4uw	714	19	100	100	CD
cord-001835-0s7ok4uw	714	20	nM	nM	NNP
cord-001835-0s7ok4uw	714	21	)	)	-RRB-
cord-001835-0s7ok4uw	714	22	comparable	comparable	JJ
cord-001835-0s7ok4uw	714	23	to	to	IN
cord-001835-0s7ok4uw	714	24	the	the	DT
cord-001835-0s7ok4uw	714	25	native	native	JJ
cord-001835-0s7ok4uw	714	26	ligand	ligand	NN
cord-001835-0s7ok4uw	714	27	IL-6	IL-6	NNP
cord-001835-0s7ok4uw	714	28	.	.	.
cord-001835-0s7ok4uw	715	1	When	when	WRB
cord-001835-0s7ok4uw	715	2	trypsin	trypsin	NN
cord-001835-0s7ok4uw	715	3	was	be	VBD
cord-001835-0s7ok4uw	715	4	targeted	target	VBN
cord-001835-0s7ok4uw	715	5	,	,	,
cord-001835-0s7ok4uw	715	6	peptides	peptide	NNS
cord-001835-0s7ok4uw	715	7	with	with	IN
cord-001835-0s7ok4uw	715	8	serine	serine	JJ
cord-001835-0s7ok4uw	715	9	protease	protease	NN
cord-001835-0s7ok4uw	715	10	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	715	11	activities	activity	NNS
cord-001835-0s7ok4uw	715	12	similar	similar	JJ
cord-001835-0s7ok4uw	715	13	to	to	IN
cord-001835-0s7ok4uw	715	14	STI	STI	NNP
cord-001835-0s7ok4uw	715	15	and	and	CC
cord-001835-0s7ok4uw	715	16	BPTI	BPTI	NNP
cord-001835-0s7ok4uw	715	17	(	(	-LRB-
cord-001835-0s7ok4uw	715	18	Ki	Ki	NNP
cord-001835-0s7ok4uw	715	19	30	30	CD
cord-001835-0s7ok4uw	715	20	nM	nM	NNP
cord-001835-0s7ok4uw	715	21	)	)	-RRB-
cord-001835-0s7ok4uw	715	22	were	be	VBD
cord-001835-0s7ok4uw	715	23	isolated	isolate	VBN
cord-001835-0s7ok4uw	715	24	.	.	.
cord-001835-0s7ok4uw	716	1	Specific	specific	JJ
cord-001835-0s7ok4uw	716	2	binders	binder	NNS
cord-001835-0s7ok4uw	716	3	to	to	IN
cord-001835-0s7ok4uw	716	4	a	a	DT
cord-001835-0s7ok4uw	716	5	trophic	trophic	JJ
cord-001835-0s7ok4uw	716	6	factor	factor	NN
cord-001835-0s7ok4uw	716	7	VEGF	VEGF	NNP
cord-001835-0s7ok4uw	716	8	were	be	VBD
cord-001835-0s7ok4uw	716	9	also	also	RB
cord-001835-0s7ok4uw	716	10	generated	generate	VBN
cord-001835-0s7ok4uw	716	11	from	from	IN
cord-001835-0s7ok4uw	716	12	the	the	DT
cord-001835-0s7ok4uw	716	13	3F	3F	NNP
cord-001835-0s7ok4uw	716	14	library	library	NNP
cord-001835-0s7ok4uw	716	15	.	.	.
cord-001835-0s7ok4uw	717	1	To	to	TO
cord-001835-0s7ok4uw	717	2	target	target	VB
cord-001835-0s7ok4uw	717	3	membrane	membrane	NN
cord-001835-0s7ok4uw	717	4	proteins	protein	NNS
cord-001835-0s7ok4uw	717	5	,	,	,
cord-001835-0s7ok4uw	717	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	717	7	developed	develop	VBD
cord-001835-0s7ok4uw	717	8	a	a	DT
cord-001835-0s7ok4uw	717	9	unique	unique	JJ
cord-001835-0s7ok4uw	717	10	in	in	IN
cord-001835-0s7ok4uw	717	11	-	-	HYPH
cord-001835-0s7ok4uw	717	12	vitro	vitro	FW
cord-001835-0s7ok4uw	717	13	evolution	evolution	NN
cord-001835-0s7ok4uw	717	14	system	system	NN
cord-001835-0s7ok4uw	717	15	,	,	,
cord-001835-0s7ok4uw	717	16	and	and	CC
cord-001835-0s7ok4uw	717	17	named	name	VBD
cord-001835-0s7ok4uw	717	18	it	-PRON-	PRP
cord-001835-0s7ok4uw	717	19	as	as	IN
cord-001835-0s7ok4uw	717	20	the	the	DT
cord-001835-0s7ok4uw	717	21	PERISS	PERISS	NNP
cord-001835-0s7ok4uw	717	22	(	(	-LRB-
cord-001835-0s7ok4uw	717	23	intra	intra	JJ
cord-001835-0s7ok4uw	717	24	periplasm	periplasm	JJ
cord-001835-0s7ok4uw	717	25	secretion	secretion	NN
cord-001835-0s7ok4uw	717	26	and	and	CC
cord-001835-0s7ok4uw	717	27	selection	selection	NN
cord-001835-0s7ok4uw	717	28	)	)	-RRB-
cord-001835-0s7ok4uw	717	29	method	method	NN
cord-001835-0s7ok4uw	717	30	.	.	.
cord-001835-0s7ok4uw	718	1	In	in	IN
cord-001835-0s7ok4uw	718	2	the	the	DT
cord-001835-0s7ok4uw	718	3	system	system	NN
cord-001835-0s7ok4uw	718	4	,	,	,
cord-001835-0s7ok4uw	718	5	target	target	NN
cord-001835-0s7ok4uw	718	6	membrane	membrane	NN
cord-001835-0s7ok4uw	718	7	proteins	protein	NNS
cord-001835-0s7ok4uw	718	8	are	be	VBP
cord-001835-0s7ok4uw	718	9	expressed	express	VBN
cord-001835-0s7ok4uw	718	10	in	in	IN
cord-001835-0s7ok4uw	718	11	inner	inner	JJ
cord-001835-0s7ok4uw	718	12	membrane	membrane	NN
cord-001835-0s7ok4uw	718	13	of	of	IN
cord-001835-0s7ok4uw	718	14	E.	E.	NNP
cord-001835-0s7ok4uw	718	15	coli	coli	NNS
cord-001835-0s7ok4uw	718	16	and	and	CC
cord-001835-0s7ok4uw	718	17	peptides	peptide	NNS
cord-001835-0s7ok4uw	718	18	are	be	VBP
cord-001835-0s7ok4uw	718	19	secreted	secrete	VBN
cord-001835-0s7ok4uw	718	20	to	to	IN
cord-001835-0s7ok4uw	718	21	the	the	DT
cord-001835-0s7ok4uw	718	22	periplasmic	periplasmic	JJ
cord-001835-0s7ok4uw	718	23	space	space	NN
cord-001835-0s7ok4uw	718	24	,	,	,
cord-001835-0s7ok4uw	718	25	in	in	IN
cord-001835-0s7ok4uw	718	26	between	between	IN
cord-001835-0s7ok4uw	718	27	the	the	DT
cord-001835-0s7ok4uw	718	28	inner	inner	JJ
cord-001835-0s7ok4uw	718	29	and	and	CC
cord-001835-0s7ok4uw	718	30	outer	outer	JJ
cord-001835-0s7ok4uw	718	31	membranes	membrane	NNS
cord-001835-0s7ok4uw	718	32	;	;	:
cord-001835-0s7ok4uw	718	33	and	and	CC
cord-001835-0s7ok4uw	718	34	the	the	DT
cord-001835-0s7ok4uw	718	35	space	space	NN
cord-001835-0s7ok4uw	718	36	is	be	VBZ
cord-001835-0s7ok4uw	718	37	served	serve	VBN
cord-001835-0s7ok4uw	718	38	for	for	IN
cord-001835-0s7ok4uw	718	39	interaction	interaction	NN
cord-001835-0s7ok4uw	718	40	and	and	CC
cord-001835-0s7ok4uw	718	41	selection	selection	NN
cord-001835-0s7ok4uw	718	42	.	.	.
cord-001835-0s7ok4uw	719	1	The	the	DT
cord-001835-0s7ok4uw	719	2	PERISS	periss	JJ
cord-001835-0s7ok4uw	719	3	method	method	NN
cord-001835-0s7ok4uw	719	4	enabled	enable	VBD
cord-001835-0s7ok4uw	719	5	us	-PRON-	PRP
cord-001835-0s7ok4uw	719	6	to	to	TO
cord-001835-0s7ok4uw	719	7	identify	identify	VB
cord-001835-0s7ok4uw	719	8	a	a	DT
cord-001835-0s7ok4uw	719	9	peptide	peptide	NN
cord-001835-0s7ok4uw	719	10	specific	specific	JJ
cord-001835-0s7ok4uw	719	11	to	to	IN
cord-001835-0s7ok4uw	719	12	muscarinic	muscarinic	JJ
cord-001835-0s7ok4uw	719	13	receptor	receptor	NN
cord-001835-0s7ok4uw	719	14	m2	m2	NNP
cord-001835-0s7ok4uw	719	15	subtype	subtype	NN
cord-001835-0s7ok4uw	719	16	from	from	IN
cord-001835-0s7ok4uw	719	17	the	the	DT
cord-001835-0s7ok4uw	719	18	ICK	ICK	NNP
cord-001835-0s7ok4uw	719	19	peptide	peptide	NN
cord-001835-0s7ok4uw	719	20	library	library	NN
cord-001835-0s7ok4uw	719	21	.	.	.
cord-001835-0s7ok4uw	720	1	In	in	IN
cord-001835-0s7ok4uw	720	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	720	3	,	,	,
cord-001835-0s7ok4uw	720	4	it	-PRON-	PRP
cord-001835-0s7ok4uw	720	5	was	be	VBD
cord-001835-0s7ok4uw	720	6	proved	prove	VBN
cord-001835-0s7ok4uw	720	7	that	that	IN
cord-001835-0s7ok4uw	720	8	the	the	DT
cord-001835-0s7ok4uw	720	9	library	library	NN
cord-001835-0s7ok4uw	720	10	designed	design	VBN
cord-001835-0s7ok4uw	720	11	from	from	IN
cord-001835-0s7ok4uw	720	12	the	the	DT
cord-001835-0s7ok4uw	720	13	scaffold	scaffold	NN
cord-001835-0s7ok4uw	720	14	of	of	IN
cord-001835-0s7ok4uw	720	15	peptide	peptide	NN
cord-001835-0s7ok4uw	720	16	toxin	toxin	NN
cord-001835-0s7ok4uw	720	17	,	,	,
cord-001835-0s7ok4uw	720	18	which	which	WDT
cord-001835-0s7ok4uw	720	19	evolved	evolve	VBD
cord-001835-0s7ok4uw	720	20	in	in	IN
cord-001835-0s7ok4uw	720	21	the	the	DT
cord-001835-0s7ok4uw	720	22	mode	mode	NN
cord-001835-0s7ok4uw	720	23	of	of	IN
cord-001835-0s7ok4uw	720	24	accelerated	accelerated	JJ
cord-001835-0s7ok4uw	720	25	gene	gene	NN
cord-001835-0s7ok4uw	720	26	evolution	evolution	NN
cord-001835-0s7ok4uw	720	27	,	,	,
cord-001835-0s7ok4uw	720	28	has	have	VBZ
cord-001835-0s7ok4uw	720	29	pluripotency	pluripotency	NN
cord-001835-0s7ok4uw	720	30	in	in	IN
cord-001835-0s7ok4uw	720	31	target	target	NN
cord-001835-0s7ok4uw	720	32	recognition	recognition	NN
cord-001835-0s7ok4uw	720	33	,	,	,
cord-001835-0s7ok4uw	720	34	interaction	interaction	NN
cord-001835-0s7ok4uw	720	35	and	and	CC
cord-001835-0s7ok4uw	720	36	even	even	RB
cord-001835-0s7ok4uw	720	37	bioactivity	bioactivity	NN
cord-001835-0s7ok4uw	720	38	.	.	.
cord-001835-0s7ok4uw	721	1	Phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	721	2	ammonia	ammonia	NN
cord-001835-0s7ok4uw	721	3	lyase	lyase	NN
cord-001835-0s7ok4uw	721	4	from	from	IN
cord-001835-0s7ok4uw	721	5	Petroselinum	Petroselinum	NNP
cord-001835-0s7ok4uw	721	6	cripsum	cripsum	NN
cord-001835-0s7ok4uw	722	1	(	(	-LRB-
cord-001835-0s7ok4uw	722	2	PcPAL	pcpal	NN
cord-001835-0s7ok4uw	722	3	)	)	-RRB-
cord-001835-0s7ok4uw	722	4	belongs	belong	VBZ
cord-001835-0s7ok4uw	722	5	to	to	IN
cord-001835-0s7ok4uw	722	6	the	the	DT
cord-001835-0s7ok4uw	722	7	class	class	NN
cord-001835-0s7ok4uw	722	8	of	of	IN
cord-001835-0s7ok4uw	722	9	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	722	10	containing	contain	VBG
cord-001835-0s7ok4uw	722	11	4-methylideneimidazole-5-one	4-methylideneimidazole-5-one	CD
cord-001835-0s7ok4uw	722	12	(	(	-LRB-
cord-001835-0s7ok4uw	722	13	MIO	MIO	NNP
cord-001835-0s7ok4uw	722	14	)	)	-RRB-
cord-001835-0s7ok4uw	722	15	as	as	IN
cord-001835-0s7ok4uw	722	16	a	a	DT
cord-001835-0s7ok4uw	722	17	prostetic	prostetic	JJ
cord-001835-0s7ok4uw	722	18	group	group	NN
cord-001835-0s7ok4uw	722	19	and	and	CC
cord-001835-0s7ok4uw	722	20	it	-PRON-	PRP
cord-001835-0s7ok4uw	722	21	is	be	VBZ
cord-001835-0s7ok4uw	722	22	responsible	responsible	JJ
cord-001835-0s7ok4uw	722	23	for	for	IN
cord-001835-0s7ok4uw	722	24	the	the	DT
cord-001835-0s7ok4uw	722	25	conversion	conversion	NN
cord-001835-0s7ok4uw	722	26	of	of	IN
cord-001835-0s7ok4uw	722	27	L	l	NN
cord-001835-0s7ok4uw	722	28	-	-	HYPH
cord-001835-0s7ok4uw	722	29	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	722	30	into	into	IN
cord-001835-0s7ok4uw	722	31	trans	trans	NNP
cord-001835-0s7ok4uw	722	32	-	-	JJ
cord-001835-0s7ok4uw	722	33	cinnamic	cinnamic	JJ
cord-001835-0s7ok4uw	722	34	acid	acid	NN
cord-001835-0s7ok4uw	722	35	.	.	.
cord-001835-0s7ok4uw	723	1	This	this	DT
cord-001835-0s7ok4uw	723	2	reaction	reaction	NN
cord-001835-0s7ok4uw	723	3	is	be	VBZ
cord-001835-0s7ok4uw	723	4	reversibile	reversibile	NN
cord-001835-0s7ok4uw	723	5	under	under	IN
cord-001835-0s7ok4uw	723	6	high	high	JJ
cord-001835-0s7ok4uw	723	7	ammonia	ammonia	NN
cord-001835-0s7ok4uw	723	8	concentration	concentration	NN
cord-001835-0s7ok4uw	723	9	.	.	.
cord-001835-0s7ok4uw	724	1	1	1	LS
cord-001835-0s7ok4uw	725	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	725	2	analyzed	analyze	VBD
cord-001835-0s7ok4uw	725	3	several	several	JJ
cord-001835-0s7ok4uw	725	4	factors	factor	NNS
cord-001835-0s7ok4uw	725	5	that	that	WDT
cord-001835-0s7ok4uw	725	6	can	can	MD
cord-001835-0s7ok4uw	725	7	influence	influence	VB
cord-001835-0s7ok4uw	725	8	the	the	DT
cord-001835-0s7ok4uw	725	9	enantioselective	enantioselective	JJ
cord-001835-0s7ok4uw	725	10	synthesis	synthesis	NN
cord-001835-0s7ok4uw	725	11	of	of	IN
cord-001835-0s7ok4uw	725	12	nitrophenylalanine	nitrophenylalanine	NN
cord-001835-0s7ok4uw	725	13	mediated	mediate	VBN
cord-001835-0s7ok4uw	725	14	by	by	IN
cord-001835-0s7ok4uw	725	15	whole	whole	JJ
cord-001835-0s7ok4uw	725	16	cells	cell	NNS
cord-001835-0s7ok4uw	725	17	as	as	RB
cord-001835-0s7ok4uw	725	18	well	well	RB
cord-001835-0s7ok4uw	725	19	as	as	IN
cord-001835-0s7ok4uw	725	20	purified	purify	VBN
cord-001835-0s7ok4uw	725	21	MIO	MIO	NNP
cord-001835-0s7ok4uw	725	22	-	-	HYPH
cord-001835-0s7ok4uw	725	23	containing	contain	VBG
cord-001835-0s7ok4uw	725	24	and	and	CC
cord-001835-0s7ok4uw	725	25	MIO	MIO	NNP
cord-001835-0s7ok4uw	725	26	-	-	HYPH
cord-001835-0s7ok4uw	725	27	less	less	JJR
cord-001835-0s7ok4uw	725	28	PcPALs	pcpals	NN
cord-001835-0s7ok4uw	725	29	.	.	.
cord-001835-0s7ok4uw	726	1	First	first	RB
cord-001835-0s7ok4uw	726	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	726	3	investigated	investigate	VBD
cord-001835-0s7ok4uw	726	4	the	the	DT
cord-001835-0s7ok4uw	726	5	behaviour	behaviour	NN
cord-001835-0s7ok4uw	726	6	of	of	IN
cord-001835-0s7ok4uw	726	7	the	the	DT
cord-001835-0s7ok4uw	726	8	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	726	9	depending	depend	VBG
cord-001835-0s7ok4uw	726	10	on	on	IN
cord-001835-0s7ok4uw	726	11	the	the	DT
cord-001835-0s7ok4uw	726	12	ammonia	ammonia	NN
cord-001835-0s7ok4uw	726	13	concentration	concentration	NN
cord-001835-0s7ok4uw	726	14	.	.	.
cord-001835-0s7ok4uw	727	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	727	2	also	also	RB
cord-001835-0s7ok4uw	727	3	inspected	inspect	VBD
cord-001835-0s7ok4uw	727	4	the	the	DT
cord-001835-0s7ok4uw	727	5	influence	influence	NN
cord-001835-0s7ok4uw	727	6	of	of	IN
cord-001835-0s7ok4uw	727	7	the	the	DT
cord-001835-0s7ok4uw	727	8	pH	ph	NN
cord-001835-0s7ok4uw	727	9	on	on	IN
cord-001835-0s7ok4uw	727	10	the	the	DT
cord-001835-0s7ok4uw	727	11	PcPAL	PcPAL	NNP
cord-001835-0s7ok4uw	727	12	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	727	13	biotransformations	biotransformation	NNS
cord-001835-0s7ok4uw	727	14	.	.	.
cord-001835-0s7ok4uw	728	1	Based	base	VBN
cord-001835-0s7ok4uw	728	2	on	on	IN
cord-001835-0s7ok4uw	728	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	728	4	results	result	NNS
cord-001835-0s7ok4uw	728	5	,	,	,
cord-001835-0s7ok4uw	728	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	728	7	concluded	conclude	VBD
cord-001835-0s7ok4uw	728	8	that	that	IN
cord-001835-0s7ok4uw	728	9	variation	variation	NN
cord-001835-0s7ok4uw	728	10	of	of	IN
cord-001835-0s7ok4uw	728	11	ammonia	ammonia	NN
cord-001835-0s7ok4uw	728	12	concentration	concentration	NN
cord-001835-0s7ok4uw	728	13	and	and	CC
cord-001835-0s7ok4uw	728	14	the	the	DT
cord-001835-0s7ok4uw	728	15	pH	pH	NNP
cord-001835-0s7ok4uw	728	16	leads	lead	VBZ
cord-001835-0s7ok4uw	728	17	to	to	TO
cord-001835-0s7ok4uw	728	18	decrease	decrease	VB
cord-001835-0s7ok4uw	728	19	of	of	IN
cord-001835-0s7ok4uw	728	20	enantioselectivity	enantioselectivity	NN
cord-001835-0s7ok4uw	728	21	,	,	,
cord-001835-0s7ok4uw	728	22	suggesting	suggest	VBG
cord-001835-0s7ok4uw	728	23	that	that	IN
cord-001835-0s7ok4uw	728	24	PcPAL	PcPAL	NNP
cord-001835-0s7ok4uw	728	25	is	be	VBZ
cord-001835-0s7ok4uw	728	26	able	able	JJ
cord-001835-0s7ok4uw	728	27	to	to	TO
cord-001835-0s7ok4uw	728	28	catalyze	catalyze	VB
cord-001835-0s7ok4uw	728	29	the	the	DT
cord-001835-0s7ok4uw	728	30	formation	formation	NN
cord-001835-0s7ok4uw	728	31	of	of	IN
cord-001835-0s7ok4uw	728	32	both	both	CC
cord-001835-0s7ok4uw	728	33	L	l	NN
cord-001835-0s7ok4uw	728	34	-	-	:
cord-001835-0s7ok4uw	728	35	and	and	CC
cord-001835-0s7ok4uw	728	36	D	D	NNP
cord-001835-0s7ok4uw	728	37	-	-	HYPH
cord-001835-0s7ok4uw	728	38	enantiomers	enantiomer	NNS
cord-001835-0s7ok4uw	728	39	of	of	IN
cord-001835-0s7ok4uw	728	40	electron	electron	NN
cord-001835-0s7ok4uw	728	41	-	-	HYPH
cord-001835-0s7ok4uw	728	42	deficient	deficient	JJ
cord-001835-0s7ok4uw	728	43	structures	structure	NNS
cord-001835-0s7ok4uw	728	44	.	.	.
cord-001835-0s7ok4uw	729	1	all	all	DT
cord-001835-0s7ok4uw	729	2	microbial	microbial	JJ
cord-001835-0s7ok4uw	729	3	cellulase	cellulase	NN
cord-001835-0s7ok4uw	729	4	appears	appear	VBZ
cord-001835-0s7ok4uw	729	5	to	to	TO
cord-001835-0s7ok4uw	729	6	have	have	VB
cord-001835-0s7ok4uw	729	7	a	a	DT
cord-001835-0s7ok4uw	729	8	conserved	conserve	VBN
cord-001835-0s7ok4uw	729	9	'	'	``
cord-001835-0s7ok4uw	729	10	SG	sg	NN
cord-001835-0s7ok4uw	729	11	'	'	POS
cord-001835-0s7ok4uw	729	12	amino	amino	NN
cord-001835-0s7ok4uw	729	13	acid	acid	NN
cord-001835-0s7ok4uw	729	14	sequence	sequence	NN
cord-001835-0s7ok4uw	729	15	at	at	IN
cord-001835-0s7ok4uw	729	16	an	an	DT
cord-001835-0s7ok4uw	729	17	identical	identical	JJ
cord-001835-0s7ok4uw	729	18	position	position	NN
cord-001835-0s7ok4uw	729	19	in	in	IN
cord-001835-0s7ok4uw	729	20	the	the	DT
cord-001835-0s7ok4uw	729	21	N	n	CD
cord-001835-0s7ok4uw	729	22	-	-	HYPH
cord-001835-0s7ok4uw	729	23	terminal	terminal	NN
cord-001835-0s7ok4uw	729	24	domain	domain	NN
cord-001835-0s7ok4uw	729	25	.	.	.
cord-001835-0s7ok4uw	730	1	The	the	DT
cord-001835-0s7ok4uw	730	2	properties	property	NNS
cord-001835-0s7ok4uw	730	3	of	of	IN
cord-001835-0s7ok4uw	730	4	the	the	DT
cord-001835-0s7ok4uw	730	5	N	n	CD
cord-001835-0s7ok4uw	730	6	-	-	HYPH
cord-001835-0s7ok4uw	730	7	terminal	terminal	NN
cord-001835-0s7ok4uw	730	8	15	15	CD
cord-001835-0s7ok4uw	730	9	amino	amino	NN
cord-001835-0s7ok4uw	730	10	acid	acid	NN
cord-001835-0s7ok4uw	730	11	sequence	sequence	NN
cord-001835-0s7ok4uw	730	12	were	be	VBD
cord-001835-0s7ok4uw	730	13	also	also	RB
cord-001835-0s7ok4uw	730	14	predicted	predict	VBN
cord-001835-0s7ok4uw	730	15	computationally	computationally	RB
cord-001835-0s7ok4uw	730	16	.	.	.
cord-001835-0s7ok4uw	731	1	This	this	DT
cord-001835-0s7ok4uw	731	2	analysis	analysis	NN
cord-001835-0s7ok4uw	731	3	showed	show	VBD
cord-001835-0s7ok4uw	731	4	that	that	IN
cord-001835-0s7ok4uw	731	5	N	n	CD
cord-001835-0s7ok4uw	731	6	-	-	HYPH
cord-001835-0s7ok4uw	731	7	terminal	terminal	JJ
cord-001835-0s7ok4uw	731	8	sequence	sequence	NN
cord-001835-0s7ok4uw	731	9	of	of	IN
cord-001835-0s7ok4uw	731	10	the	the	DT
cord-001835-0s7ok4uw	731	11	enzyme	enzyme	NN
cord-001835-0s7ok4uw	731	12	is	be	VBZ
cord-001835-0s7ok4uw	731	13	unstable	unstable	JJ
cord-001835-0s7ok4uw	731	14	.	.	.
cord-001835-0s7ok4uw	732	1	The	the	DT
cord-001835-0s7ok4uw	732	2	Nterminal	Nterminal	NNP
cord-001835-0s7ok4uw	732	3	sequence	sequence	NN
cord-001835-0s7ok4uw	732	4	also	also	RB
cord-001835-0s7ok4uw	732	5	showed	show	VBD
cord-001835-0s7ok4uw	732	6	potential	potential	JJ
cord-001835-0s7ok4uw	732	7	cleavage	cleavage	NN
cord-001835-0s7ok4uw	732	8	sites	site	NNS
cord-001835-0s7ok4uw	732	9	by	by	IN
cord-001835-0s7ok4uw	732	10	different	different	JJ
cord-001835-0s7ok4uw	732	11	proteases	protease	NNS
cord-001835-0s7ok4uw	732	12	which	which	WDT
cord-001835-0s7ok4uw	732	13	may	may	MD
cord-001835-0s7ok4uw	732	14	contribute	contribute	VB
cord-001835-0s7ok4uw	732	15	to	to	IN
cord-001835-0s7ok4uw	732	16	its	-PRON-	PRP$
cord-001835-0s7ok4uw	732	17	instability	instability	NN
cord-001835-0s7ok4uw	732	18	.	.	.
cord-001835-0s7ok4uw	733	1	The	the	DT
cord-001835-0s7ok4uw	733	2	secondary	secondary	JJ
cord-001835-0s7ok4uw	733	3	structure	structure	NN
cord-001835-0s7ok4uw	733	4	analysis	analysis	NN
cord-001835-0s7ok4uw	733	5	showed	show	VBD
cord-001835-0s7ok4uw	733	6	that	that	IN
cord-001835-0s7ok4uw	733	7	the	the	DT
cord-001835-0s7ok4uw	733	8	N	n	CD
cord-001835-0s7ok4uw	733	9	-	-	HYPH
cord-001835-0s7ok4uw	733	10	terminal	terminal	NN
cord-001835-0s7ok4uw	733	11	sequence	sequence	NN
cord-001835-0s7ok4uw	733	12	has	have	VBZ
cord-001835-0s7ok4uw	733	13	40	40	CD
cord-001835-0s7ok4uw	733	14	%	%	NN
cord-001835-0s7ok4uw	733	15	of	of	IN
cord-001835-0s7ok4uw	733	16	the	the	DT
cord-001835-0s7ok4uw	733	17	15	15	CD
cord-001835-0s7ok4uw	733	18	a.a	a.a	NNP
cord-001835-0s7ok4uw	733	19	.	.	NNP
cord-001835-0s7ok4uw	733	20	sequence	sequence	NN
cord-001835-0s7ok4uw	733	21	in	in	IN
cord-001835-0s7ok4uw	733	22	extended	extended	JJ
cord-001835-0s7ok4uw	733	23	strand	strand	NN
cord-001835-0s7ok4uw	733	24	and	and	CC
cord-001835-0s7ok4uw	733	25	60	60	CD
cord-001835-0s7ok4uw	733	26	%	%	NN
cord-001835-0s7ok4uw	733	27	in	in	IN
cord-001835-0s7ok4uw	733	28	random	random	JJ
cord-001835-0s7ok4uw	733	29	coil	coil	NN
cord-001835-0s7ok4uw	733	30	conformation	conformation	NN
cord-001835-0s7ok4uw	733	31	.	.	.
cord-001835-0s7ok4uw	734	1	The	the	DT
cord-001835-0s7ok4uw	734	2	N	n	CD
cord-001835-0s7ok4uw	734	3	-	-	HYPH
cord-001835-0s7ok4uw	734	4	terminal	terminal	NN
cord-001835-0s7ok4uw	734	5	sequence	sequence	NN
cord-001835-0s7ok4uw	734	6	was	be	VBD
cord-001835-0s7ok4uw	734	7	also	also	RB
cord-001835-0s7ok4uw	734	8	analyzed	analyze	VBN
cord-001835-0s7ok4uw	734	9	for	for	IN
cord-001835-0s7ok4uw	734	10	potential	potential	JJ
cord-001835-0s7ok4uw	734	11	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	734	12	sites	site	NNS
cord-001835-0s7ok4uw	734	13	.	.	.
cord-001835-0s7ok4uw	735	1	While	while	IN
cord-001835-0s7ok4uw	735	2	no	no	DT
cord-001835-0s7ok4uw	735	3	potential	potential	JJ
cord-001835-0s7ok4uw	735	4	serine	serine	NN
cord-001835-0s7ok4uw	735	5	and	and	CC
cord-001835-0s7ok4uw	735	6	threonine	threonine	NN
cord-001835-0s7ok4uw	735	7	sites	site	NNS
cord-001835-0s7ok4uw	735	8	were	be	VBD
cord-001835-0s7ok4uw	735	9	predicted	predict	VBN
cord-001835-0s7ok4uw	735	10	,	,	,
cord-001835-0s7ok4uw	735	11	two	two	CD
cord-001835-0s7ok4uw	735	12	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	735	13	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	735	14	sites	site	NNS
cord-001835-0s7ok4uw	735	15	were	be	VBD
cord-001835-0s7ok4uw	735	16	predicted	predict	VBN
cord-001835-0s7ok4uw	735	17	in	in	IN
cord-001835-0s7ok4uw	735	18	the	the	DT
cord-001835-0s7ok4uw	735	19	N	n	CD
cord-001835-0s7ok4uw	735	20	-	-	HYPH
cord-001835-0s7ok4uw	735	21	terminal	terminal	NN
cord-001835-0s7ok4uw	735	22	sequence	sequence	NN
cord-001835-0s7ok4uw	735	23	.	.	.
cord-001835-0s7ok4uw	736	1	The	the	DT
cord-001835-0s7ok4uw	736	2	N	n	CD
cord-001835-0s7ok4uw	736	3	-	-	HYPH
cord-001835-0s7ok4uw	736	4	terminal	terminal	NN
cord-001835-0s7ok4uw	736	5	sequence	sequence	NN
cord-001835-0s7ok4uw	736	6	was	be	VBD
cord-001835-0s7ok4uw	736	7	also	also	RB
cord-001835-0s7ok4uw	736	8	examined	examine	VBN
cord-001835-0s7ok4uw	736	9	for	for	IN
cord-001835-0s7ok4uw	736	10	the	the	DT
cord-001835-0s7ok4uw	736	11	presence	presence	NN
cord-001835-0s7ok4uw	736	12	of	of	IN
cord-001835-0s7ok4uw	736	13	kinase	kinase	DT
cord-001835-0s7ok4uw	736	14	specific	specific	JJ
cord-001835-0s7ok4uw	736	15	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	736	16	sites	site	NNS
cord-001835-0s7ok4uw	736	17	.	.	.
cord-001835-0s7ok4uw	737	1	The	the	DT
cord-001835-0s7ok4uw	737	2	results	result	NNS
cord-001835-0s7ok4uw	737	3	showed	show	VBD
cord-001835-0s7ok4uw	737	4	the	the	DT
cord-001835-0s7ok4uw	737	5	presence	presence	NN
cord-001835-0s7ok4uw	737	6	of	of	IN
cord-001835-0s7ok4uw	737	7	one	one	CD
cord-001835-0s7ok4uw	737	8	potential	potential	JJ
cord-001835-0s7ok4uw	737	9	site	site	NN
cord-001835-0s7ok4uw	737	10	which	which	WDT
cord-001835-0s7ok4uw	737	11	may	may	MD
cord-001835-0s7ok4uw	737	12	be	be	VB
cord-001835-0s7ok4uw	737	13	phosphorylated	phosphorylate	VBN
cord-001835-0s7ok4uw	737	14	by	by	IN
cord-001835-0s7ok4uw	737	15	PKC	PKC	NNP
cord-001835-0s7ok4uw	737	16	at	at	IN
cord-001835-0s7ok4uw	737	17	position	position	NN
cord-001835-0s7ok4uw	737	18	1	1	CD
cord-001835-0s7ok4uw	737	19	of	of	IN
cord-001835-0s7ok4uw	737	20	the	the	DT
cord-001835-0s7ok4uw	737	21	N	n	CD
cord-001835-0s7ok4uw	737	22	-	-	HYPH
cord-001835-0s7ok4uw	737	23	terminal	terminal	NN
cord-001835-0s7ok4uw	737	24	sequence	sequence	NN
cord-001835-0s7ok4uw	737	25	.	.	.
cord-001835-0s7ok4uw	738	1	The	the	DT
cord-001835-0s7ok4uw	738	2	analysis	analysis	NN
cord-001835-0s7ok4uw	738	3	for	for	IN
cord-001835-0s7ok4uw	738	4	the	the	DT
cord-001835-0s7ok4uw	738	5	prediction	prediction	NN
cord-001835-0s7ok4uw	738	6	of	of	IN
cord-001835-0s7ok4uw	738	7	the	the	DT
cord-001835-0s7ok4uw	738	8	presence	presence	NN
cord-001835-0s7ok4uw	738	9	of	of	IN
cord-001835-0s7ok4uw	738	10	OGlcNAc	OGlcNAc	NNP
cord-001835-0s7ok4uw	738	11	sites	site	NNS
cord-001835-0s7ok4uw	738	12	revealed	reveal	VBD
cord-001835-0s7ok4uw	738	13	that	that	IN
cord-001835-0s7ok4uw	738	14	two	two	CD
cord-001835-0s7ok4uw	738	15	such	such	JJ
cord-001835-0s7ok4uw	738	16	sites	site	NNS
cord-001835-0s7ok4uw	738	17	may	may	MD
cord-001835-0s7ok4uw	738	18	potentially	potentially	RB
cord-001835-0s7ok4uw	738	19	be	be	VB
cord-001835-0s7ok4uw	738	20	present	present	JJ
cord-001835-0s7ok4uw	738	21	in	in	IN
cord-001835-0s7ok4uw	738	22	the	the	DT
cord-001835-0s7ok4uw	738	23	sequence	sequence	NN
cord-001835-0s7ok4uw	738	24	.	.	.
cord-001835-0s7ok4uw	739	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	739	2	have	have	VBP
cord-001835-0s7ok4uw	739	3	also	also	RB
cord-001835-0s7ok4uw	739	4	predicted	predict	VBN
cord-001835-0s7ok4uw	739	5	the	the	DT
cord-001835-0s7ok4uw	739	6	ligand	ligand	NN
cord-001835-0s7ok4uw	739	7	binding	binding	NN
cord-001835-0s7ok4uw	739	8	site	site	NN
cord-001835-0s7ok4uw	739	9	in	in	IN
cord-001835-0s7ok4uw	739	10	the	the	DT
cord-001835-0s7ok4uw	739	11	N	n	CD
cord-001835-0s7ok4uw	739	12	-	-	HYPH
cord-001835-0s7ok4uw	739	13	terminal	terminal	JJ
cord-001835-0s7ok4uw	739	14	sequence	sequence	NN
cord-001835-0s7ok4uw	739	15	of	of	IN
cord-001835-0s7ok4uw	739	16	the	the	DT
cord-001835-0s7ok4uw	739	17	protein	protein	NN
cord-001835-0s7ok4uw	739	18	.	.	.
cord-001835-0s7ok4uw	739	19	 	 	_SP
cord-001835-0s7ok4uw	740	1	Protein	protein	NN
cord-001835-0s7ok4uw	740	2	arginine	arginine	NN
cord-001835-0s7ok4uw	740	3	methylation	methylation	NN
cord-001835-0s7ok4uw	740	4	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	740	5	by	by	IN
cord-001835-0s7ok4uw	740	6	protein	protein	NN
cord-001835-0s7ok4uw	740	7	arginine	arginine	NN
cord-001835-0s7ok4uw	740	8	methyltransferases	methyltransferase	NNS
cord-001835-0s7ok4uw	740	9	(	(	-LRB-
cord-001835-0s7ok4uw	740	10	PRMTs	prmt	NNS
cord-001835-0s7ok4uw	740	11	)	)	-RRB-
cord-001835-0s7ok4uw	740	12	,	,	,
cord-001835-0s7ok4uw	740	13	is	be	VBZ
cord-001835-0s7ok4uw	740	14	a	a	DT
cord-001835-0s7ok4uw	740	15	pivotal	pivotal	JJ
cord-001835-0s7ok4uw	740	16	protein	protein	NN
cord-001835-0s7ok4uw	740	17	post	post	JJ
cord-001835-0s7ok4uw	740	18	-	-	JJ
cord-001835-0s7ok4uw	740	19	translational	translational	JJ
cord-001835-0s7ok4uw	740	20	modification	modification	NN
cord-001835-0s7ok4uw	740	21	involved	involve	VBN
cord-001835-0s7ok4uw	740	22	in	in	IN
cord-001835-0s7ok4uw	740	23	a	a	DT
cord-001835-0s7ok4uw	740	24	growing	grow	VBG
cord-001835-0s7ok4uw	740	25	number	number	NN
cord-001835-0s7ok4uw	740	26	of	of	IN
cord-001835-0s7ok4uw	740	27	physiological	physiological	JJ
cord-001835-0s7ok4uw	740	28	and	and	CC
cord-001835-0s7ok4uw	740	29	pathological	pathological	JJ
cord-001835-0s7ok4uw	740	30	processes	process	NNS
cord-001835-0s7ok4uw	740	31	including	include	VBG
cord-001835-0s7ok4uw	740	32	signal	signal	NN
cord-001835-0s7ok4uw	740	33	transduction	transduction	NN
cord-001835-0s7ok4uw	740	34	,	,	,
cord-001835-0s7ok4uw	740	35	proliferation	proliferation	NN
cord-001835-0s7ok4uw	740	36	,	,	,
cord-001835-0s7ok4uw	740	37	differentiation	differentiation	NN
cord-001835-0s7ok4uw	740	38	and	and	CC
cord-001835-0s7ok4uw	740	39	malignancy	malignancy	NN
cord-001835-0s7ok4uw	740	40	.	.	.
cord-001835-0s7ok4uw	741	1	PRMT1	PRMT1	NNP
cord-001835-0s7ok4uw	741	2	accounts	account	VBZ
cord-001835-0s7ok4uw	741	3	for	for	IN
cord-001835-0s7ok4uw	741	4	the	the	DT
cord-001835-0s7ok4uw	741	5	majority	majority	NN
cord-001835-0s7ok4uw	741	6	of	of	IN
cord-001835-0s7ok4uw	741	7	protein	protein	NN
cord-001835-0s7ok4uw	741	8	arginine	arginine	NN
cord-001835-0s7ok4uw	741	9	methyltransferase	methyltransferase	NN
cord-001835-0s7ok4uw	741	10	activity	activity	NN
cord-001835-0s7ok4uw	741	11	in	in	IN
cord-001835-0s7ok4uw	741	12	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	741	13	cells	cell	NNS
cord-001835-0s7ok4uw	741	14	and	and	CC
cord-001835-0s7ok4uw	741	15	,	,	,
cord-001835-0s7ok4uw	741	16	in	in	IN
cord-001835-0s7ok4uw	741	17	consistence	consistence	NN
cord-001835-0s7ok4uw	741	18	,	,	,
cord-001835-0s7ok4uw	741	19	a	a	DT
cord-001835-0s7ok4uw	741	20	large	large	JJ
cord-001835-0s7ok4uw	741	21	amount	amount	NN
cord-001835-0s7ok4uw	741	22	of	of	IN
cord-001835-0s7ok4uw	741	23	cellular	cellular	JJ
cord-001835-0s7ok4uw	741	24	substrates	substrate	NNS
cord-001835-0s7ok4uw	741	25	have	have	VBP
cord-001835-0s7ok4uw	741	26	been	be	VBN
cord-001835-0s7ok4uw	741	27	identified	identify	VBN
cord-001835-0s7ok4uw	741	28	.	.	.
cord-001835-0s7ok4uw	742	1	Several	several	JJ
cord-001835-0s7ok4uw	742	2	studies	study	NNS
cord-001835-0s7ok4uw	742	3	have	have	VBP
cord-001835-0s7ok4uw	742	4	reported	report	VBN
cord-001835-0s7ok4uw	742	5	that	that	IN
cord-001835-0s7ok4uw	742	6	the	the	DT
cord-001835-0s7ok4uw	742	7	activity	activity	NN
cord-001835-0s7ok4uw	742	8	of	of	IN
cord-001835-0s7ok4uw	742	9	PRMT1	prmt1	NN
cord-001835-0s7ok4uw	742	10	changes	change	NNS
cord-001835-0s7ok4uw	742	11	upon	upon	IN
cord-001835-0s7ok4uw	742	12	stimulation	stimulation	NN
cord-001835-0s7ok4uw	742	13	in	in	IN
cord-001835-0s7ok4uw	742	14	various	various	JJ
cord-001835-0s7ok4uw	742	15	cellular	cellular	JJ
cord-001835-0s7ok4uw	742	16	processes	process	NNS
cord-001835-0s7ok4uw	742	17	.	.	.
cord-001835-0s7ok4uw	743	1	In	in	IN
cord-001835-0s7ok4uw	743	2	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	743	3	cells	cell	NNS
cord-001835-0s7ok4uw	743	4	,	,	,
cord-001835-0s7ok4uw	743	5	PRMT1	PRMT1	NNP
cord-001835-0s7ok4uw	743	6	exists	exist	VBZ
cord-001835-0s7ok4uw	743	7	in	in	IN
cord-001835-0s7ok4uw	743	8	a	a	DT
cord-001835-0s7ok4uw	743	9	high	high	JJ
cord-001835-0s7ok4uw	743	10	molecular	molecular	JJ
cord-001835-0s7ok4uw	743	11	weight	weight	NN
cord-001835-0s7ok4uw	743	12	complex	complex	NN
cord-001835-0s7ok4uw	743	13	.	.	.
cord-001835-0s7ok4uw	744	1	The	the	DT
cord-001835-0s7ok4uw	744	2	interacting	interact	VBG
cord-001835-0s7ok4uw	744	3	partners	partner	NNS
cord-001835-0s7ok4uw	744	4	of	of	IN
cord-001835-0s7ok4uw	744	5	PRMT1	PRMT1	NNS
cord-001835-0s7ok4uw	744	6	,	,	,
cord-001835-0s7ok4uw	744	7	such	such	JJ
cord-001835-0s7ok4uw	744	8	as	as	IN
cord-001835-0s7ok4uw	744	9	antiproliferative	antiproliferative	JJ
cord-001835-0s7ok4uw	744	10	proteins	protein	NNS
cord-001835-0s7ok4uw	744	11	BTG1	BTG1	NNP
cord-001835-0s7ok4uw	744	12	and	and	CC
cord-001835-0s7ok4uw	744	13	BTG2	BTG2	NNP
cord-001835-0s7ok4uw	744	14	,	,	,
cord-001835-0s7ok4uw	744	15	protein	protein	NN
cord-001835-0s7ok4uw	744	16	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	744	17	2A	2a	CD
cord-001835-0s7ok4uw	744	18	,	,	,
cord-001835-0s7ok4uw	744	19	the	the	DT
cord-001835-0s7ok4uw	744	20	orphan	orphan	NN
cord-001835-0s7ok4uw	744	21	receptor	receptor	NN
cord-001835-0s7ok4uw	744	22	TR3	TR3	NNP
cord-001835-0s7ok4uw	744	23	,	,	,
cord-001835-0s7ok4uw	744	24	and	and	CC
cord-001835-0s7ok4uw	744	25	CCR4-associated	CCR4-associated	NNP
cord-001835-0s7ok4uw	744	26	factor	factor	NNP
cord-001835-0s7ok4uw	744	27	1(hCAF1	1(hcaf1	CD
cord-001835-0s7ok4uw	744	28	)	)	-RRB-
cord-001835-0s7ok4uw	744	29	are	be	VBP
cord-001835-0s7ok4uw	744	30	shown	show	VBN
cord-001835-0s7ok4uw	744	31	to	to	TO
cord-001835-0s7ok4uw	744	32	play	play	VB
cord-001835-0s7ok4uw	744	33	a	a	DT
cord-001835-0s7ok4uw	744	34	role	role	NN
cord-001835-0s7ok4uw	744	35	in	in	IN
cord-001835-0s7ok4uw	744	36	modulating	modulate	VBG
cord-001835-0s7ok4uw	744	37	the	the	DT
cord-001835-0s7ok4uw	744	38	methyltransferase	methyltransferase	NN
cord-001835-0s7ok4uw	744	39	activity	activity	NN
cord-001835-0s7ok4uw	744	40	and	and	CC
cord-001835-0s7ok4uw	744	41	the	the	DT
cord-001835-0s7ok4uw	744	42	substrate	substrate	JJ
cord-001835-0s7ok4uw	744	43	selectivity	selectivity	NN
cord-001835-0s7ok4uw	744	44	of	of	IN
cord-001835-0s7ok4uw	744	45	PRMT1	PRMT1	NNS
cord-001835-0s7ok4uw	744	46	.	.	.
cord-001835-0s7ok4uw	745	1	Due	due	IN
cord-001835-0s7ok4uw	745	2	to	to	IN
cord-001835-0s7ok4uw	745	3	the	the	DT
cord-001835-0s7ok4uw	745	4	pivotal	pivotal	JJ
cord-001835-0s7ok4uw	745	5	roles	role	NNS
cord-001835-0s7ok4uw	745	6	of	of	IN
cord-001835-0s7ok4uw	745	7	PRMT1	PRMT1	NNS
cord-001835-0s7ok4uw	745	8	in	in	IN
cord-001835-0s7ok4uw	745	9	physiological	physiological	JJ
cord-001835-0s7ok4uw	745	10	and	and	CC
cord-001835-0s7ok4uw	745	11	pathological	pathological	JJ
cord-001835-0s7ok4uw	745	12	conditions	condition	NNS
cord-001835-0s7ok4uw	745	13	,	,	,
cord-001835-0s7ok4uw	745	14	intensive	intensive	JJ
cord-001835-0s7ok4uw	745	15	efforts	effort	NNS
cord-001835-0s7ok4uw	745	16	have	have	VBP
cord-001835-0s7ok4uw	745	17	been	be	VBN
cord-001835-0s7ok4uw	745	18	put	put	VBN
cord-001835-0s7ok4uw	745	19	on	on	IN
cord-001835-0s7ok4uw	745	20	the	the	DT
cord-001835-0s7ok4uw	745	21	search	search	NN
cord-001835-0s7ok4uw	745	22	of	of	IN
cord-001835-0s7ok4uw	745	23	small	small	JJ
cord-001835-0s7ok4uw	745	24	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	745	25	chemical	chemical	NN
cord-001835-0s7ok4uw	745	26	molecules	molecule	NNS
cord-001835-0s7ok4uw	745	27	which	which	WDT
cord-001835-0s7ok4uw	745	28	can	can	MD
cord-001835-0s7ok4uw	745	29	efficiently	efficiently	RB
cord-001835-0s7ok4uw	745	30	modulate	modulate	VB
cord-001835-0s7ok4uw	745	31	the	the	DT
cord-001835-0s7ok4uw	745	32	activity	activity	NN
cord-001835-0s7ok4uw	745	33	of	of	IN
cord-001835-0s7ok4uw	745	34	PRMT1	PRMT1	NNS
cord-001835-0s7ok4uw	745	35	for	for	IN
cord-001835-0s7ok4uw	745	36	the	the	DT
cord-001835-0s7ok4uw	745	37	potential	potential	JJ
cord-001835-0s7ok4uw	745	38	development	development	NN
cord-001835-0s7ok4uw	745	39	of	of	IN
cord-001835-0s7ok4uw	745	40	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	745	41	.	.	.
cord-001835-0s7ok4uw	746	1	In	in	IN
cord-001835-0s7ok4uw	746	2	light	light	NN
cord-001835-0s7ok4uw	746	3	of	of	IN
cord-001835-0s7ok4uw	746	4	this	this	DT
cord-001835-0s7ok4uw	746	5	,	,	,
cord-001835-0s7ok4uw	746	6	the	the	DT
cord-001835-0s7ok4uw	746	7	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	746	8	small	small	JJ
cord-001835-0s7ok4uw	746	9	molecules	molecule	NNS
cord-001835-0s7ok4uw	746	10	that	that	WDT
cord-001835-0s7ok4uw	746	11	either	either	CC
cord-001835-0s7ok4uw	746	12	transmit	transmit	VB
cord-001835-0s7ok4uw	746	13	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	746	14	stimulation	stimulation	NN
cord-001835-0s7ok4uw	746	15	or	or	CC
cord-001835-0s7ok4uw	746	16	act	act	NN
cord-001835-0s7ok4uw	746	17	as	as	IN
cord-001835-0s7ok4uw	746	18	cofactor	cofactor	NN
cord-001835-0s7ok4uw	746	19	to	to	TO
cord-001835-0s7ok4uw	746	20	dictate	dictate	VB
cord-001835-0s7ok4uw	746	21	the	the	DT
cord-001835-0s7ok4uw	746	22	activity	activity	NN
cord-001835-0s7ok4uw	746	23	of	of	IN
cord-001835-0s7ok4uw	746	24	PRMTs	prmt	NNS
cord-001835-0s7ok4uw	746	25	in	in	IN
cord-001835-0s7ok4uw	746	26	cells	cell	NNS
cord-001835-0s7ok4uw	746	27	are	be	VBP
cord-001835-0s7ok4uw	746	28	still	still	RB
cord-001835-0s7ok4uw	746	29	poorly	poorly	RB
cord-001835-0s7ok4uw	746	30	understood	understand	VBN
cord-001835-0s7ok4uw	746	31	.	.	.
cord-001835-0s7ok4uw	747	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	747	2	study	study	NN
cord-001835-0s7ok4uw	747	3	focused	focus	VBD
cord-001835-0s7ok4uw	747	4	on	on	IN
cord-001835-0s7ok4uw	747	5	examining	examine	VBG
cord-001835-0s7ok4uw	747	6	how	how	WRB
cord-001835-0s7ok4uw	747	7	cellular	cellular	JJ
cord-001835-0s7ok4uw	747	8	ions	ion	NNS
cord-001835-0s7ok4uw	747	9	might	may	MD
cord-001835-0s7ok4uw	747	10	affect	affect	VB
cord-001835-0s7ok4uw	747	11	the	the	DT
cord-001835-0s7ok4uw	747	12	activity	activity	NN
cord-001835-0s7ok4uw	747	13	of	of	IN
cord-001835-0s7ok4uw	747	14	PRMT1	PRMT1	NNS
cord-001835-0s7ok4uw	747	15	and	and	CC
cord-001835-0s7ok4uw	747	16	found	find	VBD
cord-001835-0s7ok4uw	747	17	that	that	IN
cord-001835-0s7ok4uw	747	18	divalent	divalent	JJ
cord-001835-0s7ok4uw	747	19	and	and	CC
cord-001835-0s7ok4uw	747	20	monovalent	monovalent	JJ
cord-001835-0s7ok4uw	747	21	ions	ion	NNS
cord-001835-0s7ok4uw	747	22	differentially	differentially	RB
cord-001835-0s7ok4uw	747	23	modulated	modulate	VBD
cord-001835-0s7ok4uw	747	24	the	the	DT
cord-001835-0s7ok4uw	747	25	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	747	26	activity	activity	NN
cord-001835-0s7ok4uw	747	27	of	of	IN
cord-001835-0s7ok4uw	747	28	PRMT1	prmt1	NN
cord-001835-0s7ok4uw	747	29	toward	toward	IN
cord-001835-0s7ok4uw	747	30	different	different	JJ
cord-001835-0s7ok4uw	747	31	substrates	substrate	NNS
cord-001835-0s7ok4uw	747	32	.	.	.
cord-001835-0s7ok4uw	748	1	Oligomerisation	oligomerisation	NN
cord-001835-0s7ok4uw	748	2	properties	property	NNS
cord-001835-0s7ok4uw	748	3	of	of	IN
cord-001835-0s7ok4uw	748	4	light	light	JJ
cord-001835-0s7ok4uw	748	5	-	-	HYPH
cord-001835-0s7ok4uw	748	6	dependent	dependent	JJ
cord-001835-0s7ok4uw	748	7	protochlorophyllide	protochlorophyllide	NN
cord-001835-0s7ok4uw	748	8	oxidoreductase	oxidoreductase	NN
cord-001835-0s7ok4uw	748	9	Prothoracicotropic	Prothoracicotropic	NNP
cord-001835-0s7ok4uw	748	10	hormone	hormone	NN
cord-001835-0s7ok4uw	748	11	(	(	-LRB-
cord-001835-0s7ok4uw	748	12	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	748	13	)	)	-RRB-
cord-001835-0s7ok4uw	748	14	is	be	VBZ
cord-001835-0s7ok4uw	748	15	one	one	CD
cord-001835-0s7ok4uw	748	16	of	of	IN
cord-001835-0s7ok4uw	748	17	the	the	DT
cord-001835-0s7ok4uw	748	18	most	most	RBS
cord-001835-0s7ok4uw	748	19	important	important	JJ
cord-001835-0s7ok4uw	748	20	neuropeptide	neuropeptide	NN
cord-001835-0s7ok4uw	748	21	regulators	regulator	NNS
cord-001835-0s7ok4uw	748	22	for	for	IN
cord-001835-0s7ok4uw	748	23	insect	insect	NN
cord-001835-0s7ok4uw	748	24	molting	molting	NN
cord-001835-0s7ok4uw	748	25	and	and	CC
cord-001835-0s7ok4uw	748	26	metamorphosis	metamorphosis	NN
cord-001835-0s7ok4uw	748	27	.	.	.
cord-001835-0s7ok4uw	749	1	However	however	RB
cord-001835-0s7ok4uw	749	2	,	,	,
cord-001835-0s7ok4uw	749	3	preparation	preparation	NN
cord-001835-0s7ok4uw	749	4	of	of	IN
cord-001835-0s7ok4uw	749	5	its	-PRON-	PRP$
cord-001835-0s7ok4uw	749	6	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	749	7	protein	protein	NN
cord-001835-0s7ok4uw	749	8	has	have	VBZ
cord-001835-0s7ok4uw	749	9	hardly	hardly	RB
cord-001835-0s7ok4uw	749	10	been	be	VBN
cord-001835-0s7ok4uw	749	11	successful	successful	JJ
cord-001835-0s7ok4uw	749	12	,	,	,
cord-001835-0s7ok4uw	749	13	because	because	IN
cord-001835-0s7ok4uw	749	14	it	-PRON-	PRP
cord-001835-0s7ok4uw	749	15	is	be	VBZ
cord-001835-0s7ok4uw	749	16	a	a	DT
cord-001835-0s7ok4uw	749	17	homodimer	homodimer	JJ
cord-001835-0s7ok4uw	749	18	protein	protein	NN
cord-001835-0s7ok4uw	749	19	with	with	IN
cord-001835-0s7ok4uw	749	20	very	very	RB
cord-001835-0s7ok4uw	749	21	complicated	complicated	JJ
cord-001835-0s7ok4uw	749	22	disulfide	disulfide	NN
cord-001835-0s7ok4uw	749	23	-	-	HYPH
cord-001835-0s7ok4uw	749	24	bond	bond	NN
cord-001835-0s7ok4uw	749	25	structure	structure	NN
cord-001835-0s7ok4uw	749	26	.	.	.
cord-001835-0s7ok4uw	750	1	For	for	IN
cord-001835-0s7ok4uw	750	2	example	example	NN
cord-001835-0s7ok4uw	750	3	,	,	,
cord-001835-0s7ok4uw	750	4	silkworm	silkworm	NN
cord-001835-0s7ok4uw	750	5	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	750	6	has	have	VBZ
cord-001835-0s7ok4uw	750	7	three	three	CD
cord-001835-0s7ok4uw	750	8	intramolecular	intramolecular	JJ
cord-001835-0s7ok4uw	750	9	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	750	10	bonds	bond	NNS
cord-001835-0s7ok4uw	750	11	in	in	IN
cord-001835-0s7ok4uw	750	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	750	13	109-residue	109-residue	CD
cord-001835-0s7ok4uw	750	14	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	750	15	chain	chain	NN
cord-001835-0s7ok4uw	750	16	,	,	,
cord-001835-0s7ok4uw	750	17	and	and	CC
cord-001835-0s7ok4uw	750	18	the	the	DT
cord-001835-0s7ok4uw	750	19	two	two	CD
cord-001835-0s7ok4uw	750	20	chains	chain	NNS
cord-001835-0s7ok4uw	750	21	are	be	VBP
cord-001835-0s7ok4uw	750	22	further	further	RB
cord-001835-0s7ok4uw	750	23	linked	link	VBN
cord-001835-0s7ok4uw	750	24	by	by	IN
cord-001835-0s7ok4uw	750	25	an	an	DT
cord-001835-0s7ok4uw	750	26	additional	additional	JJ
cord-001835-0s7ok4uw	750	27	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	750	28	disulfide	disulfide	NN
cord-001835-0s7ok4uw	750	29	bond	bond	NN
cord-001835-0s7ok4uw	750	30	to	to	TO
cord-001835-0s7ok4uw	750	31	form	form	VB
cord-001835-0s7ok4uw	750	32	the	the	DT
cord-001835-0s7ok4uw	750	33	homomeric	homomeric	NNP
cord-001835-0s7ok4uw	750	34	dimer	dimer	NNP
cord-001835-0s7ok4uw	750	35	.	.	.
cord-001835-0s7ok4uw	751	1	Although	although	IN
cord-001835-0s7ok4uw	751	2	the	the	DT
cord-001835-0s7ok4uw	751	3	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	751	4	silkworm	silkworm	NN
cord-001835-0s7ok4uw	751	5	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	751	6	was	be	VBD
cord-001835-0s7ok4uw	751	7	previously	previously	RB
cord-001835-0s7ok4uw	751	8	expressed	express	VBN
cord-001835-0s7ok4uw	751	9	in	in	IN
cord-001835-0s7ok4uw	751	10	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	751	11	coli	coli	NNS
cord-001835-0s7ok4uw	751	12	,	,	,
cord-001835-0s7ok4uw	751	13	the	the	DT
cord-001835-0s7ok4uw	751	14	product	product	NN
cord-001835-0s7ok4uw	751	15	was	be	VBD
cord-001835-0s7ok4uw	751	16	obtained	obtain	VBN
cord-001835-0s7ok4uw	751	17	only	only	RB
cord-001835-0s7ok4uw	751	18	in	in	IN
cord-001835-0s7ok4uw	751	19	precipitation	precipitation	NN
cord-001835-0s7ok4uw	751	20	fractions	fraction	NNS
cord-001835-0s7ok4uw	751	21	,	,	,
cord-001835-0s7ok4uw	751	22	and	and	CC
cord-001835-0s7ok4uw	751	23	refolding	refolde	VBG
cord-001835-0s7ok4uw	751	24	of	of	IN
cord-001835-0s7ok4uw	751	25	the	the	DT
cord-001835-0s7ok4uw	751	26	precipitated	precipitate	VBN
cord-001835-0s7ok4uw	751	27	protein	protein	NN
cord-001835-0s7ok4uw	751	28	provided	provide	VBD
cord-001835-0s7ok4uw	751	29	the	the	DT
cord-001835-0s7ok4uw	751	30	active	active	JJ
cord-001835-0s7ok4uw	751	31	dimer	dimer	NN
cord-001835-0s7ok4uw	751	32	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	751	33	in	in	IN
cord-001835-0s7ok4uw	751	34	very	very	RB
cord-001835-0s7ok4uw	751	35	poor	poor	JJ
cord-001835-0s7ok4uw	751	36	yield	yield	NN
cord-001835-0s7ok4uw	751	37	.	.	.
cord-001835-0s7ok4uw	752	1	Under	under	IN
cord-001835-0s7ok4uw	752	2	such	such	JJ
cord-001835-0s7ok4uw	752	3	reductive	reductive	JJ
cord-001835-0s7ok4uw	752	4	conditions	condition	NNS
cord-001835-0s7ok4uw	752	5	as	as	IN
cord-001835-0s7ok4uw	752	6	in	in	IN
cord-001835-0s7ok4uw	752	7	cytosol	cytosol	NN
cord-001835-0s7ok4uw	752	8	of	of	IN
cord-001835-0s7ok4uw	752	9	the	the	DT
cord-001835-0s7ok4uw	752	10	E.	E.	NNP
cord-001835-0s7ok4uw	752	11	coli	coli	NNS
cord-001835-0s7ok4uw	752	12	cells	cell	NNS
cord-001835-0s7ok4uw	752	13	,	,	,
cord-001835-0s7ok4uw	752	14	formation	formation	NN
cord-001835-0s7ok4uw	752	15	of	of	IN
cord-001835-0s7ok4uw	752	16	the	the	DT
cord-001835-0s7ok4uw	752	17	correct	correct	JJ
cord-001835-0s7ok4uw	752	18	disulfide	disulfide	NN
cord-001835-0s7ok4uw	752	19	-	-	HYPH
cord-001835-0s7ok4uw	752	20	bond	bond	NN
cord-001835-0s7ok4uw	752	21	arrangement	arrangement	NN
cord-001835-0s7ok4uw	752	22	must	must	MD
cord-001835-0s7ok4uw	752	23	be	be	VB
cord-001835-0s7ok4uw	752	24	difficult	difficult	JJ
cord-001835-0s7ok4uw	752	25	.	.	.
cord-001835-0s7ok4uw	753	1	Alternatively	alternatively	RB
cord-001835-0s7ok4uw	753	2	,	,	,
cord-001835-0s7ok4uw	753	3	for	for	IN
cord-001835-0s7ok4uw	753	4	the	the	DT
cord-001835-0s7ok4uw	753	5	heterologous	heterologous	JJ
cord-001835-0s7ok4uw	753	6	expression	expression	NN
cord-001835-0s7ok4uw	753	7	of	of	IN
cord-001835-0s7ok4uw	753	8	the	the	DT
cord-001835-0s7ok4uw	753	9	silkworm	silkworm	NN
cord-001835-0s7ok4uw	753	10	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	753	11	,	,	,
cord-001835-0s7ok4uw	753	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	753	13	employed	employ	VBD
cord-001835-0s7ok4uw	753	14	Brevibacillus	Brevibacillus	NNP
cord-001835-0s7ok4uw	753	15	choshinensis	choshinensis	NNP
cord-001835-0s7ok4uw	753	16	(	(	-LRB-
cord-001835-0s7ok4uw	753	17	formally	formally	RB
cord-001835-0s7ok4uw	753	18	referred	refer	VBN
cord-001835-0s7ok4uw	753	19	to	to	IN
cord-001835-0s7ok4uw	753	20	as	as	IN
cord-001835-0s7ok4uw	753	21	Bacillus	Bacillus	NNP
cord-001835-0s7ok4uw	753	22	brevis	brevis	NNP
cord-001835-0s7ok4uw	753	23	)	)	-RRB-
cord-001835-0s7ok4uw	753	24	,	,	,
cord-001835-0s7ok4uw	753	25	which	which	WDT
cord-001835-0s7ok4uw	753	26	has	have	VBZ
cord-001835-0s7ok4uw	753	27	achieved	achieve	VBN
cord-001835-0s7ok4uw	753	28	good	good	JJ
cord-001835-0s7ok4uw	753	29	results	result	NNS
cord-001835-0s7ok4uw	753	30	in	in	IN
cord-001835-0s7ok4uw	753	31	expression	expression	NN
cord-001835-0s7ok4uw	753	32	of	of	IN
cord-001835-0s7ok4uw	753	33	various	various	JJ
cord-001835-0s7ok4uw	753	34	disulfide	disulfide	NN
cord-001835-0s7ok4uw	753	35	-	-	HYPH
cord-001835-0s7ok4uw	753	36	bond	bond	NN
cord-001835-0s7ok4uw	753	37	-	-	HYPH
cord-001835-0s7ok4uw	753	38	containing	contain	VBG
cord-001835-0s7ok4uw	753	39	proteins	protein	NNS
cord-001835-0s7ok4uw	753	40	.	.	.
cord-001835-0s7ok4uw	754	1	In	in	IN
cord-001835-0s7ok4uw	754	2	this	this	DT
cord-001835-0s7ok4uw	754	3	study	study	NN
cord-001835-0s7ok4uw	754	4	,	,	,
cord-001835-0s7ok4uw	754	5	the	the	DT
cord-001835-0s7ok4uw	754	6	silkworm	silkworm	NN
cord-001835-0s7ok4uw	754	7	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	754	8	was	be	VBD
cord-001835-0s7ok4uw	754	9	expressed	express	VBN
cord-001835-0s7ok4uw	754	10	in	in	IN
cord-001835-0s7ok4uw	754	11	the	the	DT
cord-001835-0s7ok4uw	754	12	Brevibacillus	Brevibacillus	NNP
cord-001835-0s7ok4uw	754	13	cells	cell	NNS
cord-001835-0s7ok4uw	754	14	with	with	IN
cord-001835-0s7ok4uw	754	15	an	an	DT
cord-001835-0s7ok4uw	754	16	additional	additional	JJ
cord-001835-0s7ok4uw	754	17	His6-tag	His6-tag	NNP
cord-001835-0s7ok4uw	754	18	sequence	sequence	NN
cord-001835-0s7ok4uw	754	19	at	at	IN
cord-001835-0s7ok4uw	754	20	the	the	DT
cord-001835-0s7ok4uw	754	21	C	C	NNP
cord-001835-0s7ok4uw	754	22	-	-	HYPH
cord-001835-0s7ok4uw	754	23	terminus	terminus	NN
cord-001835-0s7ok4uw	754	24	,	,	,
cord-001835-0s7ok4uw	754	25	for	for	IN
cord-001835-0s7ok4uw	754	26	easier	easy	JJR
cord-001835-0s7ok4uw	754	27	detection	detection	NN
cord-001835-0s7ok4uw	754	28	and	and	CC
cord-001835-0s7ok4uw	754	29	purification	purification	NN
cord-001835-0s7ok4uw	754	30	.	.	.
cord-001835-0s7ok4uw	755	1	First	first	RB
cord-001835-0s7ok4uw	755	2	of	of	IN
cord-001835-0s7ok4uw	755	3	all	all	DT
cord-001835-0s7ok4uw	755	4	,	,	,
cord-001835-0s7ok4uw	755	5	since	since	IN
cord-001835-0s7ok4uw	755	6	the	the	DT
cord-001835-0s7ok4uw	755	7	Brevibacillus	Brevibacillus	NNP
cord-001835-0s7ok4uw	755	8	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	755	9	are	be	VBP
cord-001835-0s7ok4uw	755	10	equipped	equip	VBN
cord-001835-0s7ok4uw	755	11	with	with	IN
cord-001835-0s7ok4uw	755	12	a	a	DT
cord-001835-0s7ok4uw	755	13	secretory	secretory	JJ
cord-001835-0s7ok4uw	755	14	system	system	NN
cord-001835-0s7ok4uw	755	15	of	of	IN
cord-001835-0s7ok4uw	755	16	the	the	DT
cord-001835-0s7ok4uw	755	17	expressed	express	VBN
cord-001835-0s7ok4uw	755	18	proteins	protein	NNS
cord-001835-0s7ok4uw	755	19	,	,	,
cord-001835-0s7ok4uw	755	20	a	a	DT
cord-001835-0s7ok4uw	755	21	secretory	secretory	JJ
cord-001835-0s7ok4uw	755	22	signal	signal	NN
cord-001835-0s7ok4uw	755	23	sequence	sequence	NN
cord-001835-0s7ok4uw	755	24	to	to	TO
cord-001835-0s7ok4uw	755	25	be	be	VB
cord-001835-0s7ok4uw	755	26	attached	attach	VBN
cord-001835-0s7ok4uw	755	27	before	before	IN
cord-001835-0s7ok4uw	755	28	the	the	DT
cord-001835-0s7ok4uw	755	29	silkworm	silkworm	NN
cord-001835-0s7ok4uw	755	30	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	755	31	was	be	VBD
cord-001835-0s7ok4uw	755	32	carefully	carefully	RB
cord-001835-0s7ok4uw	755	33	selected	select	VBN
cord-001835-0s7ok4uw	755	34	.	.	.
cord-001835-0s7ok4uw	756	1	Among	among	IN
cord-001835-0s7ok4uw	756	2	four	four	CD
cord-001835-0s7ok4uw	756	3	candidates	candidate	NNS
cord-001835-0s7ok4uw	756	4	in	in	IN
cord-001835-0s7ok4uw	756	5	a	a	DT
cord-001835-0s7ok4uw	756	6	commerciallyavailable	commerciallyavailable	JJ
cord-001835-0s7ok4uw	756	7	kit	kit	NN
cord-001835-0s7ok4uw	756	8	,	,	,
cord-001835-0s7ok4uw	756	9	a	a	DT
cord-001835-0s7ok4uw	756	10	signal	signal	JJ
cord-001835-0s7ok4uw	756	11	sequence	sequence	NN
cord-001835-0s7ok4uw	756	12	derived	derive	VBN
cord-001835-0s7ok4uw	756	13	from	from	IN
cord-001835-0s7ok4uw	756	14	an	an	DT
cord-001835-0s7ok4uw	756	15	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	756	16	cell	cell	NN
cord-001835-0s7ok4uw	756	17	-	-	HYPH
cord-001835-0s7ok4uw	756	18	wall	wall	NN
cord-001835-0s7ok4uw	756	19	protein	protein	NN
cord-001835-0s7ok4uw	756	20	MWP	MWP	NNP
cord-001835-0s7ok4uw	756	21	gave	give	VBD
cord-001835-0s7ok4uw	756	22	better	well	JJR
cord-001835-0s7ok4uw	756	23	results	result	NNS
cord-001835-0s7ok4uw	756	24	in	in	IN
cord-001835-0s7ok4uw	756	25	expression	expression	NN
cord-001835-0s7ok4uw	756	26	levels	level	NNS
cord-001835-0s7ok4uw	756	27	of	of	IN
cord-001835-0s7ok4uw	756	28	the	the	DT
cord-001835-0s7ok4uw	756	29	protein	protein	NN
cord-001835-0s7ok4uw	756	30	.	.	.
cord-001835-0s7ok4uw	757	1	Second	second	RB
cord-001835-0s7ok4uw	757	2	,	,	,
cord-001835-0s7ok4uw	757	3	incubation	incubation	NN
cord-001835-0s7ok4uw	757	4	time	time	NN
cord-001835-0s7ok4uw	757	5	of	of	IN
cord-001835-0s7ok4uw	757	6	the	the	DT
cord-001835-0s7ok4uw	757	7	cells	cell	NNS
cord-001835-0s7ok4uw	757	8	was	be	VBD
cord-001835-0s7ok4uw	757	9	optimized	optimize	VBN
cord-001835-0s7ok4uw	757	10	,	,	,
cord-001835-0s7ok4uw	757	11	because	because	IN
cord-001835-0s7ok4uw	757	12	an	an	DT
cord-001835-0s7ok4uw	757	13	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	757	14	state	state	NN
cord-001835-0s7ok4uw	757	15	of	of	IN
cord-001835-0s7ok4uw	757	16	the	the	DT
cord-001835-0s7ok4uw	757	17	secreted	secrete	VBN
cord-001835-0s7ok4uw	757	18	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	757	19	in	in	IN
cord-001835-0s7ok4uw	757	20	the	the	DT
cord-001835-0s7ok4uw	757	21	cell	cell	NN
cord-001835-0s7ok4uw	757	22	culture	culture	NN
cord-001835-0s7ok4uw	757	23	medium	medium	NN
cord-001835-0s7ok4uw	757	24	changed	change	VBD
cord-001835-0s7ok4uw	757	25	with	with	IN
cord-001835-0s7ok4uw	757	26	the	the	DT
cord-001835-0s7ok4uw	757	27	time	time	NN
cord-001835-0s7ok4uw	757	28	.	.	.
cord-001835-0s7ok4uw	758	1	In	in	IN
cord-001835-0s7ok4uw	758	2	the	the	DT
cord-001835-0s7ok4uw	758	3	medium	medium	NN
cord-001835-0s7ok4uw	758	4	,	,	,
cord-001835-0s7ok4uw	758	5	various	various	JJ
cord-001835-0s7ok4uw	758	6	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	758	7	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	758	8	including	include	VBG
cord-001835-0s7ok4uw	758	9	a	a	DT
cord-001835-0s7ok4uw	758	10	monomer	monomer	NN
cord-001835-0s7ok4uw	758	11	and	and	CC
cord-001835-0s7ok4uw	758	12	a	a	DT
cord-001835-0s7ok4uw	758	13	dimer	dimer	NN
cord-001835-0s7ok4uw	758	14	were	be	VBD
cord-001835-0s7ok4uw	758	15	initially	initially	RB
cord-001835-0s7ok4uw	758	16	observed	observe	VBN
cord-001835-0s7ok4uw	758	17	,	,	,
cord-001835-0s7ok4uw	758	18	but	but	CC
cord-001835-0s7ok4uw	758	19	higher	high	JJR
cord-001835-0s7ok4uw	758	20	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	758	21	became	become	VBD
cord-001835-0s7ok4uw	758	22	a	a	DT
cord-001835-0s7ok4uw	758	23	major	major	JJ
cord-001835-0s7ok4uw	758	24	portion	portion	NN
cord-001835-0s7ok4uw	758	25	of	of	IN
cord-001835-0s7ok4uw	758	26	the	the	DT
cord-001835-0s7ok4uw	758	27	secreted	secrete	VBN
cord-001835-0s7ok4uw	758	28	product	product	NN
cord-001835-0s7ok4uw	758	29	after	after	IN
cord-001835-0s7ok4uw	758	30	longer	long	JJR
cord-001835-0s7ok4uw	758	31	incubation	incubation	NN
cord-001835-0s7ok4uw	758	32	than	than	IN
cord-001835-0s7ok4uw	758	33	48	48	CD
cord-001835-0s7ok4uw	758	34	h.	h.	NN
cord-001835-0s7ok4uw	758	35	Incubation	Incubation	NNP
cord-001835-0s7ok4uw	758	36	for	for	IN
cord-001835-0s7ok4uw	758	37	24	24	CD
cord-001835-0s7ok4uw	758	38	-	-	SYM
cord-001835-0s7ok4uw	758	39	36	36	CD
cord-001835-0s7ok4uw	758	40	h	h	NN
cord-001835-0s7ok4uw	758	41	may	may	MD
cord-001835-0s7ok4uw	758	42	be	be	VB
cord-001835-0s7ok4uw	758	43	suitable	suitable	JJ
cord-001835-0s7ok4uw	758	44	for	for	IN
cord-001835-0s7ok4uw	758	45	obtaining	obtain	VBG
cord-001835-0s7ok4uw	758	46	the	the	DT
cord-001835-0s7ok4uw	758	47	native	native	JJ
cord-001835-0s7ok4uw	758	48	dimer	dimer	NN
cord-001835-0s7ok4uw	758	49	form	form	NN
cord-001835-0s7ok4uw	758	50	of	of	IN
cord-001835-0s7ok4uw	758	51	the	the	DT
cord-001835-0s7ok4uw	758	52	silkworm	silkworm	NN
cord-001835-0s7ok4uw	758	53	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	758	54	.	.	.
cord-001835-0s7ok4uw	759	1	To	to	TO
cord-001835-0s7ok4uw	759	2	remove	remove	VB
cord-001835-0s7ok4uw	759	3	the	the	DT
cord-001835-0s7ok4uw	759	4	undesired	undesired	JJ
cord-001835-0s7ok4uw	759	5	monomer	monomer	NN
cord-001835-0s7ok4uw	759	6	and	and	CC
cord-001835-0s7ok4uw	759	7	higher	high	JJR
cord-001835-0s7ok4uw	759	8	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	759	9	,	,	,
cord-001835-0s7ok4uw	759	10	which	which	WDT
cord-001835-0s7ok4uw	759	11	mostly	mostly	RB
cord-001835-0s7ok4uw	759	12	retained	retain	VBD
cord-001835-0s7ok4uw	759	13	free	free	JJ
cord-001835-0s7ok4uw	759	14	sulfhydryl	sulfhydryl	NN
cord-001835-0s7ok4uw	759	15	groups	group	NNS
cord-001835-0s7ok4uw	759	16	,	,	,
cord-001835-0s7ok4uw	759	17	the	the	DT
cord-001835-0s7ok4uw	759	18	secreted	secrete	VBN
cord-001835-0s7ok4uw	759	19	proteins	protein	NNS
cord-001835-0s7ok4uw	759	20	were	be	VBD
cord-001835-0s7ok4uw	759	21	treated	treat	VBN
cord-001835-0s7ok4uw	759	22	with	with	IN
cord-001835-0s7ok4uw	759	23	maleimide	maleimide	NNP
cord-001835-0s7ok4uw	759	24	-	-	HYPH
cord-001835-0s7ok4uw	759	25	PEG2-biotin	PEG2-biotin	NNS
cord-001835-0s7ok4uw	759	26	.	.	.
cord-001835-0s7ok4uw	760	1	In	in	IN
cord-001835-0s7ok4uw	760	2	the	the	DT
cord-001835-0s7ok4uw	760	3	purification	purification	NN
cord-001835-0s7ok4uw	760	4	using	use	VBG
cord-001835-0s7ok4uw	760	5	a	a	DT
cord-001835-0s7ok4uw	760	6	Ni1-NTA	ni1-nta	JJ
cord-001835-0s7ok4uw	760	7	column	column	NN
cord-001835-0s7ok4uw	760	8	,	,	,
cord-001835-0s7ok4uw	760	9	the	the	DT
cord-001835-0s7ok4uw	760	10	dimer	dimer	NN
cord-001835-0s7ok4uw	760	11	of	of	IN
cord-001835-0s7ok4uw	760	12	the	the	DT
cord-001835-0s7ok4uw	760	13	His6-tagged	his6-tagged	CD
cord-001835-0s7ok4uw	760	14	silkworm	silkworm	NN
cord-001835-0s7ok4uw	760	15	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	760	16	was	be	VBD
cord-001835-0s7ok4uw	760	17	eluted	elute	VBN
cord-001835-0s7ok4uw	760	18	with	with	IN
cord-001835-0s7ok4uw	760	19	an	an	DT
cord-001835-0s7ok4uw	760	20	imidazole	imidazole	JJ
cord-001835-0s7ok4uw	760	21	gradient	gradient	NN
cord-001835-0s7ok4uw	760	22	,	,	,
cord-001835-0s7ok4uw	760	23	separately	separately	RB
cord-001835-0s7ok4uw	760	24	ahead	ahead	RB
cord-001835-0s7ok4uw	760	25	of	of	IN
cord-001835-0s7ok4uw	760	26	other	other	JJ
cord-001835-0s7ok4uw	760	27	biotinylated	biotinylated	JJ
cord-001835-0s7ok4uw	760	28	proteins	protein	NNS
cord-001835-0s7ok4uw	760	29	,	,	,
cord-001835-0s7ok4uw	760	30	probably	probably	RB
cord-001835-0s7ok4uw	760	31	due	due	IN
cord-001835-0s7ok4uw	760	32	to	to	IN
cord-001835-0s7ok4uw	760	33	interaction	interaction	NN
cord-001835-0s7ok4uw	760	34	of	of	IN
cord-001835-0s7ok4uw	760	35	the	the	DT
cord-001835-0s7ok4uw	760	36	PEG2	PEG2	NNP
cord-001835-0s7ok4uw	760	37	spacer	spacer	NN
cord-001835-0s7ok4uw	760	38	with	with	IN
cord-001835-0s7ok4uw	760	39	the	the	DT
cord-001835-0s7ok4uw	760	40	Ni1-NTA	ni1-nta	JJ
cord-001835-0s7ok4uw	760	41	groups	group	NNS
cord-001835-0s7ok4uw	760	42	of	of	IN
cord-001835-0s7ok4uw	760	43	the	the	DT
cord-001835-0s7ok4uw	760	44	resin	resin	NN
cord-001835-0s7ok4uw	760	45	.	.	.
cord-001835-0s7ok4uw	761	1	After	after	IN
cord-001835-0s7ok4uw	761	2	the	the	DT
cord-001835-0s7ok4uw	761	3	reversed	reverse	VBN
cord-001835-0s7ok4uw	761	4	-	-	HYPH
cord-001835-0s7ok4uw	761	5	phase	phase	NN
cord-001835-0s7ok4uw	761	6	HPLC	HPLC	NNP
cord-001835-0s7ok4uw	761	7	purification	purification	NN
cord-001835-0s7ok4uw	761	8	,	,	,
cord-001835-0s7ok4uw	761	9	the	the	DT
cord-001835-0s7ok4uw	761	10	final	final	JJ
cord-001835-0s7ok4uw	761	11	product	product	NN
cord-001835-0s7ok4uw	761	12	showed	show	VBD
cord-001835-0s7ok4uw	761	13	a	a	DT
cord-001835-0s7ok4uw	761	14	single	single	JJ
cord-001835-0s7ok4uw	761	15	band	band	NN
cord-001835-0s7ok4uw	761	16	on	on	IN
cord-001835-0s7ok4uw	761	17	the	the	DT
cord-001835-0s7ok4uw	761	18	nonreductive	nonreductive	NNP
cord-001835-0s7ok4uw	761	19	SDS	SDS	NNP
cord-001835-0s7ok4uw	761	20	-	-	HYPH
cord-001835-0s7ok4uw	761	21	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	761	22	,	,	,
cord-001835-0s7ok4uw	761	23	and	and	CC
cord-001835-0s7ok4uw	761	24	it	-PRON-	PRP
cord-001835-0s7ok4uw	761	25	had	have	VBD
cord-001835-0s7ok4uw	761	26	adequate	adequate	JJ
cord-001835-0s7ok4uw	761	27	ecdysone	ecdysone	NN
cord-001835-0s7ok4uw	761	28	-	-	HYPH
cord-001835-0s7ok4uw	761	29	releasing	release	VBG
cord-001835-0s7ok4uw	761	30	activity	activity	NN
cord-001835-0s7ok4uw	761	31	from	from	IN
cord-001835-0s7ok4uw	761	32	isolated	isolate	VBN
cord-001835-0s7ok4uw	761	33	silkworm	silkworm	NN
cord-001835-0s7ok4uw	761	34	prothoracic	prothoracic	NN
cord-001835-0s7ok4uw	761	35	glands	gland	NNS
cord-001835-0s7ok4uw	761	36	.	.	.
cord-001835-0s7ok4uw	762	1	The	the	DT
cord-001835-0s7ok4uw	762	2	Brevibacillus	Brevibacillus	NNP
cord-001835-0s7ok4uw	762	3	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	762	4	are	be	VBP
cord-001835-0s7ok4uw	762	5	most	most	RBS
cord-001835-0s7ok4uw	762	6	promising	promising	JJ
cord-001835-0s7ok4uw	762	7	host	host	NN
cord-001835-0s7ok4uw	762	8	cells	cell	NNS
cord-001835-0s7ok4uw	762	9	for	for	IN
cord-001835-0s7ok4uw	762	10	the	the	DT
cord-001835-0s7ok4uw	762	11	heterologous	heterologous	JJ
cord-001835-0s7ok4uw	762	12	production	production	NN
cord-001835-0s7ok4uw	762	13	of	of	IN
cord-001835-0s7ok4uw	762	14	the	the	DT
cord-001835-0s7ok4uw	762	15	insect	insect	NN
cord-001835-0s7ok4uw	762	16	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	762	17	.	.	.
cord-001835-0s7ok4uw	763	1	Role	role	NN
cord-001835-0s7ok4uw	763	2	of	of	IN
cord-001835-0s7ok4uw	763	3	the	the	DT
cord-001835-0s7ok4uw	763	4	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	763	5	bridges	bridge	NNS
cord-001835-0s7ok4uw	763	6	in	in	IN
cord-001835-0s7ok4uw	763	7	the	the	DT
cord-001835-0s7ok4uw	763	8	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	763	9	region	region	NN
cord-001835-0s7ok4uw	763	10	of	of	IN
cord-001835-0s7ok4uw	763	11	the	the	DT
cord-001835-0s7ok4uw	763	12	insect	insect	NN
cord-001835-0s7ok4uw	763	13	prothoracicotropichormone	prothoracicotropichormone	NN
cord-001835-0s7ok4uw	763	14	receptor	receptor	NN
cord-001835-0s7ok4uw	763	15	,	,	,
cord-001835-0s7ok4uw	763	16	Torso	Torso	NNP
cord-001835-0s7ok4uw	763	17	Torso	Torso	NNP
cord-001835-0s7ok4uw	763	18	is	be	VBZ
cord-001835-0s7ok4uw	763	19	an	an	DT
cord-001835-0s7ok4uw	763	20	insect	insect	NN
cord-001835-0s7ok4uw	763	21	cellular	cellular	JJ
cord-001835-0s7ok4uw	763	22	-	-	HYPH
cord-001835-0s7ok4uw	763	23	membrane	membrane	NN
cord-001835-0s7ok4uw	763	24	protein	protein	NN
cord-001835-0s7ok4uw	763	25	,	,	,
cord-001835-0s7ok4uw	763	26	which	which	WDT
cord-001835-0s7ok4uw	763	27	was	be	VBD
cord-001835-0s7ok4uw	763	28	recently	recently	RB
cord-001835-0s7ok4uw	763	29	identified	identify	VBN
cord-001835-0s7ok4uw	763	30	as	as	IN
cord-001835-0s7ok4uw	763	31	a	a	DT
cord-001835-0s7ok4uw	763	32	receptor	receptor	NN
cord-001835-0s7ok4uw	763	33	for	for	IN
cord-001835-0s7ok4uw	763	34	prothoracicotropic	prothoracicotropic	NNP
cord-001835-0s7ok4uw	763	35	hormone	hormone	NN
cord-001835-0s7ok4uw	763	36	(	(	-LRB-
cord-001835-0s7ok4uw	763	37	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	763	38	)	)	-RRB-
cord-001835-0s7ok4uw	763	39	.	.	.
cord-001835-0s7ok4uw	764	1	Although	although	IN
cord-001835-0s7ok4uw	764	2	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	764	3	is	be	VBZ
cord-001835-0s7ok4uw	764	4	one	one	CD
cord-001835-0s7ok4uw	764	5	of	of	IN
cord-001835-0s7ok4uw	764	6	the	the	DT
cord-001835-0s7ok4uw	764	7	important	important	JJ
cord-001835-0s7ok4uw	764	8	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	764	9	molecules	molecule	NNS
cord-001835-0s7ok4uw	764	10	in	in	IN
cord-001835-0s7ok4uw	764	11	insect	insect	NN
cord-001835-0s7ok4uw	764	12	molting	molting	NN
cord-001835-0s7ok4uw	764	13	and	and	CC
cord-001835-0s7ok4uw	764	14	metamorphosis	metamorphosis	NN
cord-001835-0s7ok4uw	764	15	,	,	,
cord-001835-0s7ok4uw	764	16	activation	activation	NN
cord-001835-0s7ok4uw	764	17	mechanism	mechanism	NN
cord-001835-0s7ok4uw	764	18	of	of	IN
cord-001835-0s7ok4uw	764	19	Torso	Torso	NNP
cord-001835-0s7ok4uw	764	20	by	by	IN
cord-001835-0s7ok4uw	764	21	the	the	DT
cord-001835-0s7ok4uw	764	22	ligand	ligand	NN
cord-001835-0s7ok4uw	764	23	has	have	VBZ
cord-001835-0s7ok4uw	764	24	not	not	RB
cord-001835-0s7ok4uw	764	25	been	be	VBN
cord-001835-0s7ok4uw	764	26	elucidated	elucidate	VBN
cord-001835-0s7ok4uw	764	27	yet	yet	RB
cord-001835-0s7ok4uw	764	28	.	.	.
cord-001835-0s7ok4uw	765	1	In	in	IN
cord-001835-0s7ok4uw	765	2	this	this	DT
cord-001835-0s7ok4uw	765	3	study	study	NN
cord-001835-0s7ok4uw	765	4	,	,	,
cord-001835-0s7ok4uw	765	5	an	an	DT
cord-001835-0s7ok4uw	765	6	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	765	7	manner	manner	NN
cord-001835-0s7ok4uw	765	8	of	of	IN
cord-001835-0s7ok4uw	765	9	the	the	DT
cord-001835-0s7ok4uw	765	10	silkworm	silkworm	NN
cord-001835-0s7ok4uw	765	11	Torso	Torso	NNP
cord-001835-0s7ok4uw	765	12	was	be	VBD
cord-001835-0s7ok4uw	765	13	examined	examine	VBN
cord-001835-0s7ok4uw	765	14	,	,	,
cord-001835-0s7ok4uw	765	15	using	use	VBG
cord-001835-0s7ok4uw	765	16	heterologous	heterologous	JJ
cord-001835-0s7ok4uw	765	17	expression	expression	NN
cord-001835-0s7ok4uw	765	18	in	in	IN
cord-001835-0s7ok4uw	765	19	Drosophila	Drosophila	NNP
cord-001835-0s7ok4uw	765	20	S2	S2	NNP
cord-001835-0s7ok4uw	765	21	cultured	cultured	JJ
cord-001835-0s7ok4uw	765	22	cells	cell	NNS
cord-001835-0s7ok4uw	765	23	,	,	,
cord-001835-0s7ok4uw	765	24	because	because	IN
cord-001835-0s7ok4uw	765	25	Torso	Torso	NNP
cord-001835-0s7ok4uw	765	26	is	be	VBZ
cord-001835-0s7ok4uw	765	27	a	a	DT
cord-001835-0s7ok4uw	765	28	single	single	JJ
cord-001835-0s7ok4uw	765	29	-	-	HYPH
cord-001835-0s7ok4uw	765	30	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	765	31	receptor	receptor	NN
cord-001835-0s7ok4uw	765	32	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	765	33	kinase	kinase	NN
cord-001835-0s7ok4uw	765	34	(	(	-LRB-
cord-001835-0s7ok4uw	765	35	RTK	RTK	NNP
cord-001835-0s7ok4uw	765	36	)	)	-RRB-
cord-001835-0s7ok4uw	765	37	,	,	,
cord-001835-0s7ok4uw	765	38	and	and	CC
cord-001835-0s7ok4uw	765	39	activation	activation	NN
cord-001835-0s7ok4uw	765	40	of	of	IN
cord-001835-0s7ok4uw	765	41	such	such	JJ
cord-001835-0s7ok4uw	765	42	RTKs	rtk	NNS
cord-001835-0s7ok4uw	765	43	is	be	VBZ
cord-001835-0s7ok4uw	765	44	often	often	RB
cord-001835-0s7ok4uw	765	45	triggered	trigger	VBN
cord-001835-0s7ok4uw	765	46	by	by	IN
cord-001835-0s7ok4uw	765	47	the	the	DT
cord-001835-0s7ok4uw	765	48	ligand	ligand	NN
cord-001835-0s7ok4uw	765	49	-	-	HYPH
cord-001835-0s7ok4uw	765	50	induced	induce	VBN
cord-001835-0s7ok4uw	765	51	receptor	receptor	NN
cord-001835-0s7ok4uw	765	52	dimerization	dimerization	NN
cord-001835-0s7ok4uw	765	53	on	on	IN
cord-001835-0s7ok4uw	765	54	the	the	DT
cord-001835-0s7ok4uw	765	55	cellular	cellular	JJ
cord-001835-0s7ok4uw	765	56	membrane	membrane	NN
cord-001835-0s7ok4uw	765	57	.	.	.
cord-001835-0s7ok4uw	766	1	When	when	WRB
cord-001835-0s7ok4uw	766	2	activated	activate	VBN
cord-001835-0s7ok4uw	766	3	with	with	IN
cord-001835-0s7ok4uw	766	4	silkworm	silkworm	NN
cord-001835-0s7ok4uw	766	5	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	766	6	,	,	,
cord-001835-0s7ok4uw	766	7	dimerization	dimerization	NN
cord-001835-0s7ok4uw	766	8	of	of	IN
cord-001835-0s7ok4uw	766	9	the	the	DT
cord-001835-0s7ok4uw	766	10	silkworm	silkworm	NN
cord-001835-0s7ok4uw	766	11	Torso	Torso	NNP
cord-001835-0s7ok4uw	766	12	in	in	IN
cord-001835-0s7ok4uw	766	13	the	the	DT
cord-001835-0s7ok4uw	766	14	S2	s2	NN
cord-001835-0s7ok4uw	766	15	cells	cell	NNS
cord-001835-0s7ok4uw	766	16	was	be	VBD
cord-001835-0s7ok4uw	766	17	observed	observe	VBN
cord-001835-0s7ok4uw	766	18	,	,	,
cord-001835-0s7ok4uw	766	19	using	use	VBG
cord-001835-0s7ok4uw	766	20	a	a	DT
cord-001835-0s7ok4uw	766	21	cross	cross	NN
cord-001835-0s7ok4uw	766	22	-	-	JJ
cord-001835-0s7ok4uw	766	23	linking	link	VBG
cord-001835-0s7ok4uw	766	24	reagent	reagent	NN
cord-001835-0s7ok4uw	766	25	BS3	BS3	NNP
cord-001835-0s7ok4uw	766	26	,	,	,
cord-001835-0s7ok4uw	766	27	and	and	CC
cord-001835-0s7ok4uw	766	28	the	the	DT
cord-001835-0s7ok4uw	766	29	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	766	30	receptor	receptor	NN
cord-001835-0s7ok4uw	766	31	autophosphorylation	autophosphorylation	NN
cord-001835-0s7ok4uw	766	32	and	and	CC
cord-001835-0s7ok4uw	766	33	downstream	downstream	JJ
cord-001835-0s7ok4uw	766	34	ERK	ERK	NNP
cord-001835-0s7ok4uw	766	35	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	766	36	were	be	VBD
cord-001835-0s7ok4uw	766	37	also	also	RB
cord-001835-0s7ok4uw	766	38	detected	detect	VBN
cord-001835-0s7ok4uw	766	39	.	.	.
cord-001835-0s7ok4uw	767	1	Surprisingly	surprisingly	RB
cord-001835-0s7ok4uw	767	2	,	,	,
cord-001835-0s7ok4uw	767	3	however	however	RB
cord-001835-0s7ok4uw	767	4	,	,	,
cord-001835-0s7ok4uw	767	5	the	the	DT
cord-001835-0s7ok4uw	767	6	Torso	torso	JJ
cord-001835-0s7ok4uw	767	7	dimerization	dimerization	NN
cord-001835-0s7ok4uw	767	8	was	be	VBD
cord-001835-0s7ok4uw	767	9	revealed	reveal	VBN
cord-001835-0s7ok4uw	767	10	to	to	TO
cord-001835-0s7ok4uw	767	11	occur	occur	VB
cord-001835-0s7ok4uw	767	12	even	even	RB
cord-001835-0s7ok4uw	767	13	without	without	IN
cord-001835-0s7ok4uw	767	14	the	the	DT
cord-001835-0s7ok4uw	767	15	ligand	ligand	NN
cord-001835-0s7ok4uw	767	16	stimulation	stimulation	NN
cord-001835-0s7ok4uw	767	17	,	,	,
cord-001835-0s7ok4uw	767	18	while	while	IN
cord-001835-0s7ok4uw	767	19	the	the	DT
cord-001835-0s7ok4uw	767	20	autophosphorylation	autophosphorylation	NN
cord-001835-0s7ok4uw	767	21	and	and	CC
cord-001835-0s7ok4uw	767	22	the	the	DT
cord-001835-0s7ok4uw	767	23	ERK	ERK	NNP
cord-001835-0s7ok4uw	767	24	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	767	25	were	be	VBD
cord-001835-0s7ok4uw	767	26	held	hold	VBN
cord-001835-0s7ok4uw	767	27	in	in	IN
cord-001835-0s7ok4uw	767	28	response	response	NN
cord-001835-0s7ok4uw	767	29	to	to	IN
cord-001835-0s7ok4uw	767	30	the	the	DT
cord-001835-0s7ok4uw	767	31	stimulation	stimulation	NN
cord-001835-0s7ok4uw	767	32	.	.	.
cord-001835-0s7ok4uw	768	1	When	when	WRB
cord-001835-0s7ok4uw	768	2	fractionated	fractionate	VBN
cord-001835-0s7ok4uw	768	3	by	by	IN
cord-001835-0s7ok4uw	768	4	non	non	JJ
cord-001835-0s7ok4uw	768	5	-	-	JJ
cord-001835-0s7ok4uw	768	6	reductive	reductive	JJ
cord-001835-0s7ok4uw	768	7	SDS	sds	NN
cord-001835-0s7ok4uw	768	8	-	-	HYPH
cord-001835-0s7ok4uw	768	9	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	768	10	,	,	,
cord-001835-0s7ok4uw	768	11	the	the	DT
cord-001835-0s7ok4uw	768	12	silkworm	silkworm	NN
cord-001835-0s7ok4uw	768	13	Torso	Torso	NNP
cord-001835-0s7ok4uw	768	14	showed	show	VBD
cord-001835-0s7ok4uw	768	15	an	an	DT
cord-001835-0s7ok4uw	768	16	obvious	obvious	JJ
cord-001835-0s7ok4uw	768	17	dimer	dimer	NN
cord-001835-0s7ok4uw	768	18	band	band	NN
cord-001835-0s7ok4uw	768	19	,	,	,
cord-001835-0s7ok4uw	768	20	in	in	IN
cord-001835-0s7ok4uw	768	21	addition	addition	NN
cord-001835-0s7ok4uw	768	22	to	to	IN
cord-001835-0s7ok4uw	768	23	a	a	DT
cord-001835-0s7ok4uw	768	24	faint	faint	JJ
cord-001835-0s7ok4uw	768	25	monomer	monomer	NN
cord-001835-0s7ok4uw	768	26	band	band	NN
cord-001835-0s7ok4uw	768	27	,	,	,
cord-001835-0s7ok4uw	768	28	both	both	CC
cord-001835-0s7ok4uw	768	29	with	with	IN
cord-001835-0s7ok4uw	768	30	and	and	CC
cord-001835-0s7ok4uw	768	31	without	without	IN
cord-001835-0s7ok4uw	768	32	the	the	DT
cord-001835-0s7ok4uw	768	33	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	768	34	simulation	simulation	NN
cord-001835-0s7ok4uw	768	35	,	,	,
cord-001835-0s7ok4uw	768	36	even	even	RB
cord-001835-0s7ok4uw	768	37	though	though	IN
cord-001835-0s7ok4uw	768	38	the	the	DT
cord-001835-0s7ok4uw	768	39	receptor	receptor	NN
cord-001835-0s7ok4uw	768	40	was	be	VBD
cord-001835-0s7ok4uw	768	41	not	not	RB
cord-001835-0s7ok4uw	768	42	treated	treat	VBN
cord-001835-0s7ok4uw	768	43	with	with	IN
cord-001835-0s7ok4uw	768	44	the	the	DT
cord-001835-0s7ok4uw	768	45	cross	cross	NN
cord-001835-0s7ok4uw	768	46	-	-	JJ
cord-001835-0s7ok4uw	768	47	linking	link	VBG
cord-001835-0s7ok4uw	768	48	reagent	reagent	NN
cord-001835-0s7ok4uw	768	49	.	.	.
cord-001835-0s7ok4uw	769	1	This	this	DT
cord-001835-0s7ok4uw	769	2	indicates	indicate	VBZ
cord-001835-0s7ok4uw	769	3	that	that	IN
cord-001835-0s7ok4uw	769	4	the	the	DT
cord-001835-0s7ok4uw	769	5	Torso	torso	JJ
cord-001835-0s7ok4uw	769	6	protein	protein	NN
cord-001835-0s7ok4uw	769	7	is	be	VBZ
cord-001835-0s7ok4uw	769	8	expressed	express	VBN
cord-001835-0s7ok4uw	769	9	originally	originally	RB
cord-001835-0s7ok4uw	769	10	as	as	IN
cord-001835-0s7ok4uw	769	11	a	a	DT
cord-001835-0s7ok4uw	769	12	disulfide	disulfide	NN
cord-001835-0s7ok4uw	769	13	-	-	HYPH
cord-001835-0s7ok4uw	769	14	bond	bond	NN
cord-001835-0s7ok4uw	769	15	-	-	HYPH
cord-001835-0s7ok4uw	769	16	linked	link	VBN
cord-001835-0s7ok4uw	769	17	dimer	dimer	NN
cord-001835-0s7ok4uw	769	18	.	.	.
cord-001835-0s7ok4uw	770	1	In	in	IN
cord-001835-0s7ok4uw	770	2	addition	addition	NN
cord-001835-0s7ok4uw	770	3	,	,	,
cord-001835-0s7ok4uw	770	4	by	by	IN
cord-001835-0s7ok4uw	770	5	examining	examine	VBG
cord-001835-0s7ok4uw	770	6	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	770	7	states	state	NNS
cord-001835-0s7ok4uw	770	8	of	of	IN
cord-001835-0s7ok4uw	770	9	several	several	JJ
cord-001835-0s7ok4uw	770	10	truncation	truncation	NN
cord-001835-0s7ok4uw	770	11	and	and	CC
cord-001835-0s7ok4uw	770	12	substitution	substitution	NN
cord-001835-0s7ok4uw	770	13	mutants	mutant	NNS
cord-001835-0s7ok4uw	770	14	,	,	,
cord-001835-0s7ok4uw	770	15	cysteine	cysteine	NN
cord-001835-0s7ok4uw	770	16	residues	residue	NNS
cord-001835-0s7ok4uw	770	17	in	in	IN
cord-001835-0s7ok4uw	770	18	the	the	DT
cord-001835-0s7ok4uw	770	19	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	770	20	region	region	NN
cord-001835-0s7ok4uw	770	21	were	be	VBD
cord-001835-0s7ok4uw	770	22	found	find	VBN
cord-001835-0s7ok4uw	770	23	to	to	TO
cord-001835-0s7ok4uw	770	24	participate	participate	VB
cord-001835-0s7ok4uw	770	25	in	in	IN
cord-001835-0s7ok4uw	770	26	the	the	DT
cord-001835-0s7ok4uw	770	27	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	770	28	disulfide	disulfide	NN
cord-001835-0s7ok4uw	770	29	bridges	bridge	NNS
cord-001835-0s7ok4uw	770	30	,	,	,
cord-001835-0s7ok4uw	770	31	linking	link	VBG
cord-001835-0s7ok4uw	770	32	the	the	DT
cord-001835-0s7ok4uw	770	33	two	two	CD
cord-001835-0s7ok4uw	770	34	receptor	receptor	NN
cord-001835-0s7ok4uw	770	35	molecules	molecule	NNS
cord-001835-0s7ok4uw	770	36	in	in	IN
cord-001835-0s7ok4uw	770	37	the	the	DT
cord-001835-0s7ok4uw	770	38	dimer	dimer	NN
cord-001835-0s7ok4uw	770	39	.	.	.
cord-001835-0s7ok4uw	771	1	When	when	WRB
cord-001835-0s7ok4uw	771	2	all	all	DT
cord-001835-0s7ok4uw	771	3	of	of	IN
cord-001835-0s7ok4uw	771	4	the	the	DT
cord-001835-0s7ok4uw	771	5	three	three	CD
cord-001835-0s7ok4uw	771	6	cysteines	cysteine	NNS
cord-001835-0s7ok4uw	771	7	in	in	IN
cord-001835-0s7ok4uw	771	8	the	the	DT
cord-001835-0s7ok4uw	771	9	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	771	10	region	region	NN
cord-001835-0s7ok4uw	771	11	were	be	VBD
cord-001835-0s7ok4uw	771	12	replaced	replace	VBN
cord-001835-0s7ok4uw	771	13	by	by	IN
cord-001835-0s7ok4uw	771	14	phenylalanines	phenylalanine	NNS
cord-001835-0s7ok4uw	771	15	,	,	,
cord-001835-0s7ok4uw	771	16	the	the	DT
cord-001835-0s7ok4uw	771	17	disulfide	disulfide	NN
cord-001835-0s7ok4uw	771	18	-	-	HYPH
cord-001835-0s7ok4uw	771	19	bond	bond	NN
cord-001835-0s7ok4uw	771	20	-	-	HYPH
cord-001835-0s7ok4uw	771	21	linked	link	VBN
cord-001835-0s7ok4uw	771	22	Torso	torso	JJ
cord-001835-0s7ok4uw	771	23	dimerization	dimerization	NN
cord-001835-0s7ok4uw	771	24	was	be	VBD
cord-001835-0s7ok4uw	771	25	not	not	RB
cord-001835-0s7ok4uw	771	26	observed	observe	VBN
cord-001835-0s7ok4uw	771	27	,	,	,
cord-001835-0s7ok4uw	771	28	but	but	CC
cord-001835-0s7ok4uw	771	29	spontaneous	spontaneous	JJ
cord-001835-0s7ok4uw	771	30	,	,	,
cord-001835-0s7ok4uw	771	31	ligand	ligand	NN
cord-001835-0s7ok4uw	771	32	-	-	HYPH
cord-001835-0s7ok4uw	771	33	independent	independent	JJ
cord-001835-0s7ok4uw	771	34	association	association	NN
cord-001835-0s7ok4uw	771	35	of	of	IN
cord-001835-0s7ok4uw	771	36	the	the	DT
cord-001835-0s7ok4uw	771	37	Torso	torso	JJ
cord-001835-0s7ok4uw	771	38	molecules	molecule	NNS
cord-001835-0s7ok4uw	771	39	was	be	VBD
cord-001835-0s7ok4uw	771	40	detected	detect	VBN
cord-001835-0s7ok4uw	771	41	using	use	VBG
cord-001835-0s7ok4uw	771	42	the	the	DT
cord-001835-0s7ok4uw	771	43	crosslinker	crosslinker	NNP
cord-001835-0s7ok4uw	771	44	BS3	BS3	NNP
cord-001835-0s7ok4uw	771	45	.	.	.
cord-001835-0s7ok4uw	772	1	This	this	DT
cord-001835-0s7ok4uw	772	2	spontaneous	spontaneous	JJ
cord-001835-0s7ok4uw	772	3	dimerization	dimerization	NN
cord-001835-0s7ok4uw	772	4	caused	cause	VBD
cord-001835-0s7ok4uw	772	5	the	the	DT
cord-001835-0s7ok4uw	772	6	apparent	apparent	JJ
cord-001835-0s7ok4uw	772	7	Torso	torso	JJ
cord-001835-0s7ok4uw	772	8	autophosphorylation	autophosphorylation	NN
cord-001835-0s7ok4uw	772	9	,	,	,
cord-001835-0s7ok4uw	772	10	but	but	CC
cord-001835-0s7ok4uw	772	11	it	-PRON-	PRP
cord-001835-0s7ok4uw	772	12	could	could	MD
cord-001835-0s7ok4uw	772	13	not	not	RB
cord-001835-0s7ok4uw	772	14	induce	induce	VB
cord-001835-0s7ok4uw	772	15	the	the	DT
cord-001835-0s7ok4uw	772	16	downstream	downstream	JJ
cord-001835-0s7ok4uw	772	17	ERK	ERK	NNP
cord-001835-0s7ok4uw	772	18	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	772	19	.	.	.
cord-001835-0s7ok4uw	773	1	Consequently	consequently	RB
cord-001835-0s7ok4uw	773	2	,	,	,
cord-001835-0s7ok4uw	773	3	without	without	IN
cord-001835-0s7ok4uw	773	4	the	the	DT
cord-001835-0s7ok4uw	773	5	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	773	6	disulfide	disulfide	NN
cord-001835-0s7ok4uw	773	7	bridges	bridge	NNS
cord-001835-0s7ok4uw	773	8	,	,	,
cord-001835-0s7ok4uw	773	9	Torso	Torso	NNP
cord-001835-0s7ok4uw	773	10	loses	lose	VBZ
cord-001835-0s7ok4uw	773	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	773	12	responsiveness	responsiveness	NN
cord-001835-0s7ok4uw	773	13	to	to	IN
cord-001835-0s7ok4uw	773	14	the	the	DT
cord-001835-0s7ok4uw	773	15	PTTH	PTTH	NNP
cord-001835-0s7ok4uw	773	16	stimulation	stimulation	NN
cord-001835-0s7ok4uw	773	17	.	.	.
cord-001835-0s7ok4uw	774	1	In	in	IN
cord-001835-0s7ok4uw	774	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	774	3	,	,	,
cord-001835-0s7ok4uw	774	4	the	the	DT
cord-001835-0s7ok4uw	774	5	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	774	6	bridges	bridge	NNS
cord-001835-0s7ok4uw	774	7	in	in	IN
cord-001835-0s7ok4uw	774	8	the	the	DT
cord-001835-0s7ok4uw	774	9	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	774	10	region	region	NN
cord-001835-0s7ok4uw	774	11	may	may	MD
cord-001835-0s7ok4uw	774	12	play	play	VB
cord-001835-0s7ok4uw	774	13	a	a	DT
cord-001835-0s7ok4uw	774	14	role	role	NN
cord-001835-0s7ok4uw	774	15	to	to	TO
cord-001835-0s7ok4uw	774	16	preserve	preserve	VB
cord-001835-0s7ok4uw	774	17	suitable	suitable	JJ
cord-001835-0s7ok4uw	774	18	relative	relative	JJ
cord-001835-0s7ok4uw	774	19	position	position	NN
cord-001835-0s7ok4uw	774	20	between	between	IN
cord-001835-0s7ok4uw	774	21	the	the	DT
cord-001835-0s7ok4uw	774	22	two	two	CD
cord-001835-0s7ok4uw	774	23	Torso	torso	JJ
cord-001835-0s7ok4uw	774	24	molecules	molecule	NNS
cord-001835-0s7ok4uw	774	25	,	,	,
cord-001835-0s7ok4uw	774	26	which	which	WDT
cord-001835-0s7ok4uw	774	27	could	could	MD
cord-001835-0s7ok4uw	774	28	induce	induce	VB
cord-001835-0s7ok4uw	774	29	ligand	ligand	NN
cord-001835-0s7ok4uw	774	30	-	-	HYPH
cord-001835-0s7ok4uw	774	31	dependent	dependent	JJ
cord-001835-0s7ok4uw	774	32	autophosphorylation	autophosphorylation	NN
cord-001835-0s7ok4uw	774	33	leading	lead	VBG
cord-001835-0s7ok4uw	774	34	to	to	IN
cord-001835-0s7ok4uw	774	35	activation	activation	NN
cord-001835-0s7ok4uw	774	36	of	of	IN
cord-001835-0s7ok4uw	774	37	the	the	DT
cord-001835-0s7ok4uw	774	38	downstream	downstream	JJ
cord-001835-0s7ok4uw	774	39	signaling	signal	VBG
cord-001835-0s7ok4uw	774	40	pathways	pathway	NNS
cord-001835-0s7ok4uw	774	41	in	in	IN
cord-001835-0s7ok4uw	774	42	the	the	DT
cord-001835-0s7ok4uw	774	43	cells	cell	NNS
cord-001835-0s7ok4uw	774	44	.	.	.
cord-001835-0s7ok4uw	775	1	The	the	DT
cord-001835-0s7ok4uw	775	2	yeast	yeast	NN
cord-001835-0s7ok4uw	775	3	enzyme	enzyme	NN
cord-001835-0s7ok4uw	775	4	neutral	neutral	JJ
cord-001835-0s7ok4uw	775	5	trehalase	trehalase	NN
cord-001835-0s7ok4uw	776	1	(	(	-LRB-
cord-001835-0s7ok4uw	776	2	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	776	3	,	,	,
cord-001835-0s7ok4uw	776	4	EC	EC	NNP
cord-001835-0s7ok4uw	776	5	3.2.1.28	3.2.1.28	CD
cord-001835-0s7ok4uw	776	6	)	)	-RRB-
cord-001835-0s7ok4uw	776	7	from	from	IN
cord-001835-0s7ok4uw	776	8	Saccharomyces	saccharomyce	NNS
cord-001835-0s7ok4uw	776	9	cerevisiae	cerevisiae	NNS
cord-001835-0s7ok4uw	776	10	hydrolyses	hydrolyse	VBZ
cord-001835-0s7ok4uw	776	11	the	the	DT
cord-001835-0s7ok4uw	776	12	non	non	JJ
cord-001835-0s7ok4uw	776	13	-	-	JJ
cord-001835-0s7ok4uw	776	14	reducing	reducing	JJ
cord-001835-0s7ok4uw	776	15	disaccharide	disaccharide	NN
cord-001835-0s7ok4uw	776	16	trehalose	trehalose	DT
cord-001835-0s7ok4uw	776	17	which	which	WDT
cord-001835-0s7ok4uw	776	18	serves	serve	VBZ
cord-001835-0s7ok4uw	776	19	as	as	IN
cord-001835-0s7ok4uw	776	20	an	an	DT
cord-001835-0s7ok4uw	776	21	energy	energy	NN
cord-001835-0s7ok4uw	776	22	source	source	NN
cord-001835-0s7ok4uw	776	23	and	and	CC
cord-001835-0s7ok4uw	776	24	a	a	DT
cord-001835-0s7ok4uw	776	25	universal	universal	JJ
cord-001835-0s7ok4uw	776	26	stress	stress	NN
cord-001835-0s7ok4uw	776	27	protectant	protectant	NN
cord-001835-0s7ok4uw	776	28	in	in	IN
cord-001835-0s7ok4uw	776	29	many	many	JJ
cord-001835-0s7ok4uw	776	30	different	different	JJ
cord-001835-0s7ok4uw	776	31	organisms	organism	NNS
cord-001835-0s7ok4uw	776	32	.	.	.
cord-001835-0s7ok4uw	777	1	Enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	777	2	activity	activity	NN
cord-001835-0s7ok4uw	777	3	of	of	IN
cord-001835-0s7ok4uw	777	4	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	777	5	is	be	VBZ
cord-001835-0s7ok4uw	777	6	enhanced	enhance	VBN
cord-001835-0s7ok4uw	777	7	by	by	IN
cord-001835-0s7ok4uw	777	8	the	the	DT
cord-001835-0s7ok4uw	777	9	yeast	yeast	NN
cord-001835-0s7ok4uw	777	10	14	14	CD
cord-001835-0s7ok4uw	777	11	-	-	SYM
cord-001835-0s7ok4uw	777	12	3	3	CD
cord-001835-0s7ok4uw	777	13	-	-	SYM
cord-001835-0s7ok4uw	777	14	3	3	CD
cord-001835-0s7ok4uw	777	15	protein	protein	NN
cord-001835-0s7ok4uw	777	16	(	(	-LRB-
cord-001835-0s7ok4uw	777	17	Bmh1	Bmh1	NNP
cord-001835-0s7ok4uw	777	18	and	and	CC
cord-001835-0s7ok4uw	777	19	Bmh2	Bmh2	NNP
cord-001835-0s7ok4uw	777	20	)	)	-RRB-
cord-001835-0s7ok4uw	777	21	binding	bind	VBG
cord-001835-0s7ok4uw	777	22	in	in	IN
cord-001835-0s7ok4uw	777	23	a	a	DT
cord-001835-0s7ok4uw	777	24	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	777	25	-	-	HYPH
cord-001835-0s7ok4uw	777	26	dependent	dependent	JJ
cord-001835-0s7ok4uw	777	27	manner	manner	NN
cord-001835-0s7ok4uw	777	28	.	.	.
cord-001835-0s7ok4uw	778	1	Nth1	nth1	NN
cord-001835-0s7ok4uw	778	2	activity	activity	NN
cord-001835-0s7ok4uw	778	3	is	be	VBZ
cord-001835-0s7ok4uw	778	4	also	also	RB
cord-001835-0s7ok4uw	778	5	regulated	regulate	VBN
cord-001835-0s7ok4uw	778	6	by	by	IN
cord-001835-0s7ok4uw	778	7	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	779	1	binding	bind	VBG
cord-001835-0s7ok4uw	779	2	to	to	IN
cord-001835-0s7ok4uw	779	3	the	the	DT
cord-001835-0s7ok4uw	779	4	EF	EF	NNP
cord-001835-0s7ok4uw	779	5	-	-	HYPH
cord-001835-0s7ok4uw	779	6	hand	hand	NN
cord-001835-0s7ok4uw	779	7	-	-	HYPH
cord-001835-0s7ok4uw	779	8	like	like	JJ
cord-001835-0s7ok4uw	779	9	motif	motif	NN
cord-001835-0s7ok4uw	779	10	containing	contain	VBG
cord-001835-0s7ok4uw	779	11	domain	domain	NN
cord-001835-0s7ok4uw	779	12	of	of	IN
cord-001835-0s7ok4uw	779	13	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	779	14	[	[	-LRB-
cord-001835-0s7ok4uw	779	15	1	1	CD
cord-001835-0s7ok4uw	779	16	]	]	-RRB-
cord-001835-0s7ok4uw	779	17	.The	.The	.
cord-001835-0s7ok4uw	779	18	native	native	JJ
cord-001835-0s7ok4uw	779	19	TBE	TBE	NNP
cord-001835-0s7ok4uw	779	20	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	779	21	and	and	CC
cord-001835-0s7ok4uw	779	22	analytical	analytical	JJ
cord-001835-0s7ok4uw	779	23	ultracentrifugation	ultracentrifugation	NN
cord-001835-0s7ok4uw	779	24	show	show	NN
cord-001835-0s7ok4uw	779	25	that	that	IN
cord-001835-0s7ok4uw	779	26	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	779	27	forms	form	VBZ
cord-001835-0s7ok4uw	779	28	very	very	RB
cord-001835-0s7ok4uw	779	29	stable	stable	JJ
cord-001835-0s7ok4uw	779	30	complexes	complex	NNS
cord-001835-0s7ok4uw	779	31	with	with	IN
cord-001835-0s7ok4uw	779	32	Bmh1	Bmh1	NNP
cord-001835-0s7ok4uw	779	33	and	and	CC
cord-001835-0s7ok4uw	779	34	Bmh2	Bmh2	NNP
cord-001835-0s7ok4uw	779	35	[	[	-LRB-
cord-001835-0s7ok4uw	779	36	1	1	CD
cord-001835-0s7ok4uw	779	37	]	]	-RRB-
cord-001835-0s7ok4uw	779	38	.	.	.
cord-001835-0s7ok4uw	780	1	To	to	TO
cord-001835-0s7ok4uw	780	2	study	study	VB
cord-001835-0s7ok4uw	780	3	the	the	DT
cord-001835-0s7ok4uw	780	4	structure	structure	NN
cord-001835-0s7ok4uw	780	5	of	of	IN
cord-001835-0s7ok4uw	780	6	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	780	7	alone	alone	JJ
cord-001835-0s7ok4uw	780	8	and	and	CC
cord-001835-0s7ok4uw	780	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	780	10	complex	complex	NN
cord-001835-0s7ok4uw	780	11	with	with	IN
cord-001835-0s7ok4uw	780	12	the	the	DT
cord-001835-0s7ok4uw	780	13	14	14	CD
cord-001835-0s7ok4uw	780	14	-	-	SYM
cord-001835-0s7ok4uw	780	15	3	3	CD
cord-001835-0s7ok4uw	780	16	-	-	SYM
cord-001835-0s7ok4uw	780	17	3	3	CD
cord-001835-0s7ok4uw	780	18	protein	protein	NN
cord-001835-0s7ok4uw	780	19	we	-PRON-	PRP
cord-001835-0s7ok4uw	780	20	used	use	VBD
cord-001835-0s7ok4uw	780	21	circular	circular	JJ
cord-001835-0s7ok4uw	780	22	dichroism	dichroism	NN
cord-001835-0s7ok4uw	780	23	,	,	,
cord-001835-0s7ok4uw	780	24	H	H	NNP
cord-001835-0s7ok4uw	780	25	/	/	SYM
cord-001835-0s7ok4uw	780	26	D	d	NN
cord-001835-0s7ok4uw	780	27	exchange	exchange	NN
cord-001835-0s7ok4uw	780	28	coupled	couple	VBN
cord-001835-0s7ok4uw	780	29	to	to	IN
cord-001835-0s7ok4uw	780	30	mass	mass	NN
cord-001835-0s7ok4uw	780	31	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	780	32	,	,	,
cord-001835-0s7ok4uw	780	33	chemical	chemical	NNP
cord-001835-0s7ok4uw	780	34	cross	cross	NN
cord-001835-0s7ok4uw	780	35	-	-	JJ
cord-001835-0s7ok4uw	780	36	linking	link	VBG
cord-001835-0s7ok4uw	780	37	[	[	-LRB-
cord-001835-0s7ok4uw	780	38	2	2	CD
cord-001835-0s7ok4uw	780	39	]	]	-RRB-
cord-001835-0s7ok4uw	780	40	and	and	CC
cord-001835-0s7ok4uw	780	41	small	small	JJ
cord-001835-0s7ok4uw	780	42	angle	angle	NN
cord-001835-0s7ok4uw	780	43	X	x	NN
cord-001835-0s7ok4uw	780	44	-	-	NN
cord-001835-0s7ok4uw	780	45	ray	ray	NN
cord-001835-0s7ok4uw	780	46	scattering	scattering	NN
cord-001835-0s7ok4uw	780	47	(	(	-LRB-
cord-001835-0s7ok4uw	780	48	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	780	49	)	)	-RRB-
cord-001835-0s7ok4uw	780	50	[	[	-LRB-
cord-001835-0s7ok4uw	780	51	3	3	CD
cord-001835-0s7ok4uw	780	52	]	]	-RRB-
cord-001835-0s7ok4uw	780	53	.	.	.
cord-001835-0s7ok4uw	781	1	At	at	IN
cord-001835-0s7ok4uw	781	2	the	the	DT
cord-001835-0s7ok4uw	781	3	same	same	JJ
cord-001835-0s7ok4uw	781	4	time	time	NN
cord-001835-0s7ok4uw	781	5	protein	protein	NN
cord-001835-0s7ok4uw	781	6	crystallography	crystallography	NN
cord-001835-0s7ok4uw	781	7	of	of	IN
cord-001835-0s7ok4uw	781	8	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	781	9	alone	alone	RB
cord-001835-0s7ok4uw	781	10	and	and	CC
cord-001835-0s7ok4uw	781	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	781	12	complex	complex	NN
cord-001835-0s7ok4uw	781	13	with	with	IN
cord-001835-0s7ok4uw	781	14	Bmh1	Bmh1	NNP
cord-001835-0s7ok4uw	781	15	is	be	VBZ
cord-001835-0s7ok4uw	781	16	performed	perform	VBN
cord-001835-0s7ok4uw	781	17	.	.	.
cord-001835-0s7ok4uw	782	1	The	the	DT
cord-001835-0s7ok4uw	782	2	low	low	JJ
cord-001835-0s7ok4uw	782	3	resolution	resolution	NN
cord-001835-0s7ok4uw	782	4	structure	structure	NN
cord-001835-0s7ok4uw	782	5	of	of	IN
cord-001835-0s7ok4uw	782	6	pNth1	pnth1	NN
cord-001835-0s7ok4uw	782	7	:	:	:
cord-001835-0s7ok4uw	783	1	Bmh1	Bmh1	NNP
cord-001835-0s7ok4uw	783	2	protein	protein	NN
cord-001835-0s7ok4uw	783	3	complex	complex	NN
cord-001835-0s7ok4uw	783	4	revealed	reveal	VBD
cord-001835-0s7ok4uw	783	5	that	that	IN
cord-001835-0s7ok4uw	783	6	binding	binding	NN
cord-001835-0s7ok4uw	783	7	of	of	IN
cord-001835-0s7ok4uw	783	8	Bmh1	Bmh1	NNP
cord-001835-0s7ok4uw	783	9	induces	induce	VBZ
cord-001835-0s7ok4uw	783	10	a	a	DT
cord-001835-0s7ok4uw	783	11	rearrangement	rearrangement	NN
cord-001835-0s7ok4uw	783	12	of	of	IN
cord-001835-0s7ok4uw	783	13	the	the	DT
cord-001835-0s7ok4uw	783	14	whole	whole	JJ
cord-001835-0s7ok4uw	783	15	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	783	16	molecule	molecule	NN
cord-001835-0s7ok4uw	783	17	and	and	CC
cord-001835-0s7ok4uw	783	18	that	that	IN
cord-001835-0s7ok4uw	783	19	the	the	DT
cord-001835-0s7ok4uw	783	20	region	region	NN
cord-001835-0s7ok4uw	783	21	containing	contain	VBG
cord-001835-0s7ok4uw	783	22	the	the	DT
cord-001835-0s7ok4uw	783	23	EF	EF	NNP
cord-001835-0s7ok4uw	783	24	-	-	HYPH
cord-001835-0s7ok4uw	783	25	hand	hand	NN
cord-001835-0s7ok4uw	783	26	motif	motif	NN
cord-001835-0s7ok4uw	783	27	forms	form	VBZ
cord-001835-0s7ok4uw	783	28	a	a	DT
cord-001835-0s7ok4uw	783	29	separate	separate	JJ
cord-001835-0s7ok4uw	783	30	domain	domain	NN
cord-001835-0s7ok4uw	783	31	which	which	WDT
cord-001835-0s7ok4uw	783	32	interacts	interact	VBZ
cord-001835-0s7ok4uw	783	33	with	with	IN
cord-001835-0s7ok4uw	783	34	both	both	DT
cord-001835-0s7ok4uw	783	35	Bmh1	Bmh1	NNP
cord-001835-0s7ok4uw	783	36	and	and	CC
cord-001835-0s7ok4uw	783	37	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	783	38	domain	domain	NN
cord-001835-0s7ok4uw	783	39	of	of	IN
cord-001835-0s7ok4uw	783	40	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	783	41	.	.	.
cord-001835-0s7ok4uw	784	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	784	2	proved	prove	VBD
cord-001835-0s7ok4uw	784	3	that	that	IN
cord-001835-0s7ok4uw	784	4	integrity	integrity	NN
cord-001835-0s7ok4uw	784	5	of	of	IN
cord-001835-0s7ok4uw	784	6	the	the	DT
cord-001835-0s7ok4uw	784	7	EF	EF	NNP
cord-001835-0s7ok4uw	784	8	-	-	HYPH
cord-001835-0s7ok4uw	784	9	hand	hand	NN
cord-001835-0s7ok4uw	784	10	motif	motif	NN
cord-001835-0s7ok4uw	784	11	is	be	VBZ
cord-001835-0s7ok4uw	784	12	crucial	crucial	JJ
cord-001835-0s7ok4uw	784	13	for	for	IN
cord-001835-0s7ok4uw	784	14	the	the	DT
cord-001835-0s7ok4uw	784	15	Bmh1	Bmh1	NNP
cord-001835-0s7ok4uw	784	16	mediated	mediate	VBN
cord-001835-0s7ok4uw	784	17	activation	activation	NN
cord-001835-0s7ok4uw	784	18	of	of	IN
cord-001835-0s7ok4uw	784	19	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	784	20	and	and	CC
cord-001835-0s7ok4uw	784	21	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	784	22	binding	bind	VBG
cord-001835-0s7ok4uw	784	23	.	.	.
cord-001835-0s7ok4uw	785	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	785	2	data	datum	NNS
cord-001835-0s7ok4uw	785	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	785	4	that	that	IN
cord-001835-0s7ok4uw	785	5	the	the	DT
cord-001835-0s7ok4uw	785	6	EF	EF	NNP
cord-001835-0s7ok4uw	785	7	hand	hand	NN
cord-001835-0s7ok4uw	785	8	-	-	HYPH
cord-001835-0s7ok4uw	785	9	like	like	JJ
cord-001835-0s7ok4uw	785	10	motif	motif	NN
cord-001835-0s7ok4uw	785	11	functions	function	NNS
cord-001835-0s7ok4uw	785	12	as	as	IN
cord-001835-0s7ok4uw	785	13	the	the	DT
cord-001835-0s7ok4uw	785	14	intermediary	intermediary	NN
cord-001835-0s7ok4uw	785	15	through	through	IN
cord-001835-0s7ok4uw	785	16	which	which	WDT
cord-001835-0s7ok4uw	785	17	Bmh1	Bmh1	NNP
cord-001835-0s7ok4uw	785	18	modulates	modulate	VBZ
cord-001835-0s7ok4uw	785	19	the	the	DT
cord-001835-0s7ok4uw	785	20	function	function	NN
cord-001835-0s7ok4uw	785	21	of	of	IN
cord-001835-0s7ok4uw	785	22	the	the	DT
cord-001835-0s7ok4uw	785	23	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	785	24	domain	domain	NN
cord-001835-0s7ok4uw	785	25	of	of	IN
cord-001835-0s7ok4uw	785	26	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	785	27	.	.	.
cord-001835-0s7ok4uw	786	1	These	these	DT
cord-001835-0s7ok4uw	786	2	structural	structural	JJ
cord-001835-0s7ok4uw	786	3	changes	change	NNS
cord-001835-0s7ok4uw	786	4	probably	probably	RB
cord-001835-0s7ok4uw	786	5	enable	enable	VBP
cord-001835-0s7ok4uw	786	6	the	the	DT
cord-001835-0s7ok4uw	786	7	substrate	substrate	JJ
cord-001835-0s7ok4uw	786	8	entry	entry	NN
cord-001835-0s7ok4uw	786	9	into	into	IN
cord-001835-0s7ok4uw	786	10	the	the	DT
cord-001835-0s7ok4uw	786	11	enzyme	enzyme	NN
cord-001835-0s7ok4uw	786	12	active	active	JJ
cord-001835-0s7ok4uw	786	13	site	site	NN
cord-001835-0s7ok4uw	786	14	[	[	-LRB-
cord-001835-0s7ok4uw	786	15	3	3	CD
cord-001835-0s7ok4uw	786	16	]	]	-RRB-
cord-001835-0s7ok4uw	786	17	.	.	.
cord-001835-0s7ok4uw	787	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	787	2	study	study	NN
cord-001835-0s7ok4uw	787	3	of	of	IN
cord-001835-0s7ok4uw	787	4	14	14	CD
cord-001835-0s7ok4uw	787	5	-	-	SYM
cord-001835-0s7ok4uw	787	6	3	3	CD
cord-001835-0s7ok4uw	787	7	-	-	SYM
cord-001835-0s7ok4uw	787	8	3	3	CD
cord-001835-0s7ok4uw	787	9	protein	protein	NN
cord-001835-0s7ok4uw	787	10	complex	complex	NN
cord-001835-0s7ok4uw	787	11	with	with	IN
cord-001835-0s7ok4uw	787	12	the	the	DT
cord-001835-0s7ok4uw	787	13	fully	fully	RB
cord-001835-0s7ok4uw	787	14	active	active	JJ
cord-001835-0s7ok4uw	787	15	enzyme	enzyme	NN
cord-001835-0s7ok4uw	787	16	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	787	17	offers	offer	VBZ
cord-001835-0s7ok4uw	787	18	a	a	DT
cord-001835-0s7ok4uw	787	19	unique	unique	JJ
cord-001835-0s7ok4uw	787	20	structural	structural	JJ
cord-001835-0s7ok4uw	787	21	view	view	NN
cord-001835-0s7ok4uw	787	22	of	of	IN
cord-001835-0s7ok4uw	787	23	Nth1	Nth1	NNP
cord-001835-0s7ok4uw	787	24	activation	activation	NN
cord-001835-0s7ok4uw	787	25	enabling	enable	VBG
cord-001835-0s7ok4uw	787	26	us	-PRON-	PRP
cord-001835-0s7ok4uw	787	27	to	to	TO
cord-001835-0s7ok4uw	787	28	better	better	RB
cord-001835-0s7ok4uw	787	29	understand	understand	VB
cord-001835-0s7ok4uw	787	30	the	the	DT
cord-001835-0s7ok4uw	787	31	role	role	NN
cord-001835-0s7ok4uw	787	32	of	of	IN
cord-001835-0s7ok4uw	787	33	the	the	DT
cord-001835-0s7ok4uw	787	34	14	14	CD
cord-001835-0s7ok4uw	787	35	-	-	SYM
cord-001835-0s7ok4uw	787	36	3	3	CD
cord-001835-0s7ok4uw	787	37	-	-	SYM
cord-001835-0s7ok4uw	787	38	3	3	CD
cord-001835-0s7ok4uw	787	39	proteins	protein	NNS
cord-001835-0s7ok4uw	787	40	in	in	IN
cord-001835-0s7ok4uw	787	41	regulation	regulation	NN
cord-001835-0s7ok4uw	787	42	of	of	IN
cord-001835-0s7ok4uw	787	43	other	other	JJ
cord-001835-0s7ok4uw	787	44	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	787	45	.	.	.
cord-001835-0s7ok4uw	787	46	 	 	_SP
cord-001835-0s7ok4uw	788	1	The	the	DT
cord-001835-0s7ok4uw	788	2	assembly	assembly	NN
cord-001835-0s7ok4uw	788	3	of	of	IN
cord-001835-0s7ok4uw	788	4	self	self	NN
cord-001835-0s7ok4uw	788	5	-	-	HYPH
cord-001835-0s7ok4uw	788	6	regulating	regulate	VBG
cord-001835-0s7ok4uw	788	7	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	788	8	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	788	9	pathways	pathway	NNS
cord-001835-0s7ok4uw	788	10	in	in	IN
cord-001835-0s7ok4uw	788	11	vitro	vitro	FW
cord-001835-0s7ok4uw	788	12	has	have	VBZ
cord-001835-0s7ok4uw	788	13	great	great	JJ
cord-001835-0s7ok4uw	788	14	potential	potential	NN
cord-001835-0s7ok4uw	788	15	as	as	IN
cord-001835-0s7ok4uw	788	16	alternative	alternative	JJ
cord-001835-0s7ok4uw	788	17	catalysts	catalyst	NNS
cord-001835-0s7ok4uw	788	18	for	for	IN
cord-001835-0s7ok4uw	788	19	the	the	DT
cord-001835-0s7ok4uw	788	20	high	high	JJ
cord-001835-0s7ok4uw	788	21	-	-	HYPH
cord-001835-0s7ok4uw	788	22	yield	yield	NN
cord-001835-0s7ok4uw	788	23	production	production	NN
cord-001835-0s7ok4uw	788	24	of	of	IN
cord-001835-0s7ok4uw	788	25	low	low	JJ
cord-001835-0s7ok4uw	788	26	value	value	NN
cord-001835-0s7ok4uw	788	27	/	/	SYM
cord-001835-0s7ok4uw	788	28	high	high	JJ
cord-001835-0s7ok4uw	788	29	volume	volume	NN
cord-001835-0s7ok4uw	788	30	commodity	commodity	NN
cord-001835-0s7ok4uw	788	31	chemicals	chemical	NNS
cord-001835-0s7ok4uw	788	32	from	from	IN
cord-001835-0s7ok4uw	788	33	biomass	biomass	NN
cord-001835-0s7ok4uw	788	34	.	.	.
cord-001835-0s7ok4uw	789	1	High	high	JJ
cord-001835-0s7ok4uw	789	2	yields	yield	NNS
cord-001835-0s7ok4uw	789	3	of	of	IN
cord-001835-0s7ok4uw	789	4	low	low	JJ
cord-001835-0s7ok4uw	789	5	-	-	HYPH
cord-001835-0s7ok4uw	789	6	value	value	NN
cord-001835-0s7ok4uw	789	7	/	/	SYM
cord-001835-0s7ok4uw	789	8	high	high	JJ
cord-001835-0s7ok4uw	789	9	volume	volume	NN
cord-001835-0s7ok4uw	789	10	compounds	compound	NNS
cord-001835-0s7ok4uw	789	11	that	that	WDT
cord-001835-0s7ok4uw	789	12	are	be	VBP
cord-001835-0s7ok4uw	789	13	required	require	VBN
cord-001835-0s7ok4uw	789	14	for	for	IN
cord-001835-0s7ok4uw	789	15	economic	economic	JJ
cord-001835-0s7ok4uw	789	16	viability	viability	NN
cord-001835-0s7ok4uw	789	17	is	be	VBZ
cord-001835-0s7ok4uw	789	18	particularly	particularly	RB
cord-001835-0s7ok4uw	789	19	difficult	difficult	JJ
cord-001835-0s7ok4uw	789	20	via	via	IN
cord-001835-0s7ok4uw	789	21	traditional	traditional	JJ
cord-001835-0s7ok4uw	789	22	in	in	IN
cord-001835-0s7ok4uw	789	23	vivo	vivo	NN
cord-001835-0s7ok4uw	789	24	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	789	25	engineering	engineering	NN
cord-001835-0s7ok4uw	789	26	of	of	IN
cord-001835-0s7ok4uw	789	27	microbes	microbe	NNS
cord-001835-0s7ok4uw	789	28	due	due	JJ
cord-001835-0s7ok4uw	789	29	to	to	IN
cord-001835-0s7ok4uw	789	30	competing	compete	VBG
cord-001835-0s7ok4uw	789	31	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	789	32	pathways	pathway	NNS
cord-001835-0s7ok4uw	789	33	and	and	CC
cord-001835-0s7ok4uw	789	34	toxicity	toxicity	NN
cord-001835-0s7ok4uw	789	35	.	.	.
cord-001835-0s7ok4uw	790	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	790	2	have	have	VBP
cord-001835-0s7ok4uw	790	3	developed	develop	VBN
cord-001835-0s7ok4uw	790	4	an	an	DT
cord-001835-0s7ok4uw	790	5	alternative	alternative	JJ
cord-001835-0s7ok4uw	790	6	approach	approach	NN
cord-001835-0s7ok4uw	790	7	,	,	,
cord-001835-0s7ok4uw	790	8	called	call	VBN
cord-001835-0s7ok4uw	790	9	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	790	10	biochemistry	biochemistry	NN
cord-001835-0s7ok4uw	790	11	,	,	,
cord-001835-0s7ok4uw	790	12	where	where	WRB
cord-001835-0s7ok4uw	790	13	the	the	DT
cord-001835-0s7ok4uw	790	14	glycolysis	glycolysis	NN
cord-001835-0s7ok4uw	790	15	pathway	pathway	NN
cord-001835-0s7ok4uw	790	16	of	of	IN
cord-001835-0s7ok4uw	790	17	central	central	JJ
cord-001835-0s7ok4uw	790	18	metabolism	metabolism	NN
cord-001835-0s7ok4uw	790	19	is	be	VBZ
cord-001835-0s7ok4uw	790	20	reconstituted	reconstitute	VBN
cord-001835-0s7ok4uw	790	21	in	in	IN
cord-001835-0s7ok4uw	790	22	vitro	vitro	FW
cord-001835-0s7ok4uw	790	23	with	with	IN
cord-001835-0s7ok4uw	790	24	an	an	DT
cord-001835-0s7ok4uw	790	25	anabolic	anabolic	JJ
cord-001835-0s7ok4uw	790	26	pathway	pathway	NN
cord-001835-0s7ok4uw	790	27	that	that	WDT
cord-001835-0s7ok4uw	790	28	can	can	MD
cord-001835-0s7ok4uw	790	29	produce	produce	VB
cord-001835-0s7ok4uw	790	30	useful	useful	JJ
cord-001835-0s7ok4uw	790	31	compounds	compound	NNS
cord-001835-0s7ok4uw	790	32	at	at	IN
cord-001835-0s7ok4uw	790	33	high	high	JJ
cord-001835-0s7ok4uw	790	34	yield	yield	NN
cord-001835-0s7ok4uw	790	35	.	.	.
cord-001835-0s7ok4uw	791	1	In	in	IN
cord-001835-0s7ok4uw	791	2	the	the	DT
cord-001835-0s7ok4uw	791	3	specific	specific	JJ
cord-001835-0s7ok4uw	791	4	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	791	5	biochemistry	biochemistry	NN
cord-001835-0s7ok4uw	791	6	system	system	NN
cord-001835-0s7ok4uw	791	7	described	describe	VBN
cord-001835-0s7ok4uw	791	8	,	,	,
cord-001835-0s7ok4uw	791	9	reducing	reduce	VBG
cord-001835-0s7ok4uw	791	10	equivalents	equivalent	NNS
cord-001835-0s7ok4uw	791	11	,	,	,
cord-001835-0s7ok4uw	791	12	ATP	ATP	NNP
cord-001835-0s7ok4uw	791	13	,	,	,
cord-001835-0s7ok4uw	791	14	and	and	CC
cord-001835-0s7ok4uw	791	15	carbon	carbon	NN
cord-001835-0s7ok4uw	791	16	from	from	IN
cord-001835-0s7ok4uw	791	17	glycolysis	glycolysis	NN
cord-001835-0s7ok4uw	791	18	are	be	VBP
cord-001835-0s7ok4uw	791	19	funneled	funnel	VBN
cord-001835-0s7ok4uw	791	20	through	through	IN
cord-001835-0s7ok4uw	791	21	the	the	DT
cord-001835-0s7ok4uw	791	22	anabolic	anabolic	JJ
cord-001835-0s7ok4uw	791	23	mevalonate	mevalonate	NN
cord-001835-0s7ok4uw	791	24	pathway	pathway	NN
cord-001835-0s7ok4uw	791	25	to	to	TO
cord-001835-0s7ok4uw	791	26	produce	produce	VB
cord-001835-0s7ok4uw	791	27	the	the	DT
cord-001835-0s7ok4uw	791	28	monoterpene	monoterpene	NNP
cord-001835-0s7ok4uw	791	29	limonene	limonene	NN
cord-001835-0s7ok4uw	791	30	from	from	IN
cord-001835-0s7ok4uw	791	31	glucose	glucose	NN
cord-001835-0s7ok4uw	791	32	.	.	.
cord-001835-0s7ok4uw	792	1	The	the	DT
cord-001835-0s7ok4uw	792	2	successful	successful	JJ
cord-001835-0s7ok4uw	792	3	implementation	implementation	NN
cord-001835-0s7ok4uw	792	4	of	of	IN
cord-001835-0s7ok4uw	792	5	the	the	DT
cord-001835-0s7ok4uw	792	6	in	in	FW
cord-001835-0s7ok4uw	792	7	vitro	vitro	FW
cord-001835-0s7ok4uw	792	8	pathway	pathway	NN
cord-001835-0s7ok4uw	792	9	required	require	VBN
cord-001835-0s7ok4uw	792	10	development	development	NN
cord-001835-0s7ok4uw	792	11	of	of	IN
cord-001835-0s7ok4uw	792	12	a	a	DT
cord-001835-0s7ok4uw	792	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	792	14	purge	purge	NN
cord-001835-0s7ok4uw	792	15	-	-	HYPH
cord-001835-0s7ok4uw	792	16	valve	valve	NN
cord-001835-0s7ok4uw	792	17	consisting	consisting	NN
cord-001835-0s7ok4uw	792	18	of	of	IN
cord-001835-0s7ok4uw	792	19	an	an	DT
cord-001835-0s7ok4uw	792	20	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	792	21	and	and	CC
cord-001835-0s7ok4uw	792	22	NADP1	nadp1	JJ
cord-001835-0s7ok4uw	792	23	specific	specific	JJ
cord-001835-0s7ok4uw	792	24	reductase	reductase	NN
cord-001835-0s7ok4uw	792	25	(	(	-LRB-
cord-001835-0s7ok4uw	792	26	ie	ie	NNP
cord-001835-0s7ok4uw	792	27	wild	wild	JJ
cord-001835-0s7ok4uw	792	28	-	-	HYPH
cord-001835-0s7ok4uw	792	29	type	type	NN
cord-001835-0s7ok4uw	792	30	and	and	CC
cord-001835-0s7ok4uw	792	31	mutant	mutant	JJ
cord-001835-0s7ok4uw	792	32	pyruvate	pyruvate	NN
cord-001835-0s7ok4uw	792	33	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	792	34	)	)	-RRB-
cord-001835-0s7ok4uw	792	35	,	,	,
cord-001835-0s7ok4uw	792	36	and	and	CC
cord-001835-0s7ok4uw	792	37	NADH	NADH	NNP
cord-001835-0s7ok4uw	792	38	oxidase	oxidase	NN
cord-001835-0s7ok4uw	792	39	,	,	,
cord-001835-0s7ok4uw	792	40	NoxE	NoxE	NNP
cord-001835-0s7ok4uw	792	41	,	,	,
cord-001835-0s7ok4uw	792	42	to	to	TO
cord-001835-0s7ok4uw	792	43	maintain	maintain	VB
cord-001835-0s7ok4uw	792	44	proper	proper	JJ
cord-001835-0s7ok4uw	792	45	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	792	46	/	/	SYM
cord-001835-0s7ok4uw	792	47	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	792	48	cofactor	cofactor	NN
cord-001835-0s7ok4uw	792	49	balance	balance	NN
cord-001835-0s7ok4uw	792	50	while	while	IN
cord-001835-0s7ok4uw	792	51	allowing	allow	VBG
cord-001835-0s7ok4uw	792	52	continuous	continuous	JJ
cord-001835-0s7ok4uw	792	53	carbon	carbon	NN
cord-001835-0s7ok4uw	792	54	flux	flux	NN
cord-001835-0s7ok4uw	792	55	.	.	.
cord-001835-0s7ok4uw	793	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	793	2	find	find	VBP
cord-001835-0s7ok4uw	793	3	that	that	IN
cord-001835-0s7ok4uw	793	4	the	the	DT
cord-001835-0s7ok4uw	793	5	purge	purge	NN
cord-001835-0s7ok4uw	793	6	-	-	HYPH
cord-001835-0s7ok4uw	793	7	valve	valve	NN
cord-001835-0s7ok4uw	793	8	concept	concept	NN
cord-001835-0s7ok4uw	793	9	is	be	VBZ
cord-001835-0s7ok4uw	793	10	readily	readily	RB
cord-001835-0s7ok4uw	793	11	transportable	transportable	JJ
cord-001835-0s7ok4uw	793	12	to	to	IN
cord-001835-0s7ok4uw	793	13	other	other	JJ
cord-001835-0s7ok4uw	793	14	NAD(P)H	NAD(P)H	NNP
cord-001835-0s7ok4uw	793	15	generating	generate	VBG
cord-001835-0s7ok4uw	793	16	steps	step	NNS
cord-001835-0s7ok4uw	793	17	in	in	IN
cord-001835-0s7ok4uw	793	18	central	central	JJ
cord-001835-0s7ok4uw	793	19	metabolism	metabolism	NN
cord-001835-0s7ok4uw	793	20	and	and	CC
cord-001835-0s7ok4uw	793	21	can	can	MD
cord-001835-0s7ok4uw	793	22	be	be	VB
cord-001835-0s7ok4uw	793	23	used	use	VBN
cord-001835-0s7ok4uw	793	24	to	to	TO
cord-001835-0s7ok4uw	793	25	convert	convert	VB
cord-001835-0s7ok4uw	793	26	glucose	glucose	NN
cord-001835-0s7ok4uw	793	27	to	to	IN
cord-001835-0s7ok4uw	793	28	limonene	limonene	NN
cord-001835-0s7ok4uw	793	29	at	at	IN
cord-001835-0s7ok4uw	793	30	high	high	JJ
cord-001835-0s7ok4uw	793	31	yield	yield	NN
cord-001835-0s7ok4uw	793	32	.	.	.
cord-001835-0s7ok4uw	793	33	 	 	_SP
cord-001835-0s7ok4uw	794	1	Chitinases	chitinase	NNS
cord-001835-0s7ok4uw	794	2	(	(	-LRB-
cord-001835-0s7ok4uw	794	3	EC	EC	NNP
cord-001835-0s7ok4uw	794	4	3.2.1.14	3.2.1.14	CD
cord-001835-0s7ok4uw	794	5	)	)	-RRB-
cord-001835-0s7ok4uw	794	6	are	be	VBP
cord-001835-0s7ok4uw	794	7	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	794	8	that	that	WDT
cord-001835-0s7ok4uw	794	9	randomly	randomly	RB
cord-001835-0s7ok4uw	794	10	hydrolyze	hydrolyze	VBP
cord-001835-0s7ok4uw	794	11	b-1,4	b-1,4	NN
cord-001835-0s7ok4uw	794	12	glycosidic	glycosidic	JJ
cord-001835-0s7ok4uw	794	13	bonds	bond	NNS
cord-001835-0s7ok4uw	794	14	of	of	IN
cord-001835-0s7ok4uw	794	15	chitin	chitin	NN
cord-001835-0s7ok4uw	794	16	and	and	CC
cord-001835-0s7ok4uw	794	17	produce	produce	VB
cord-001835-0s7ok4uw	794	18	N	n	CD
cord-001835-0s7ok4uw	794	19	-	-	HYPH
cord-001835-0s7ok4uw	794	20	acetylchitooligosaccharide	acetylchitooligosaccharide	NNP
cord-001835-0s7ok4uw	794	21	(	(	-LRB-
cord-001835-0s7ok4uw	794	22	(	(	-LRB-
cord-001835-0s7ok4uw	794	23	GlcNAc)n	GlcNAc)n	NNP
cord-001835-0s7ok4uw	794	24	)	)	-RRB-
cord-001835-0s7ok4uw	794	25	that	that	WDT
cord-001835-0s7ok4uw	794	26	has	have	VBZ
cord-001835-0s7ok4uw	794	27	various	various	JJ
cord-001835-0s7ok4uw	794	28	physiological	physiological	JJ
cord-001835-0s7ok4uw	794	29	functions	function	NNS
cord-001835-0s7ok4uw	794	30	such	such	JJ
cord-001835-0s7ok4uw	794	31	as	as	IN
cord-001835-0s7ok4uw	794	32	immunostimulatory	immunostimulatory	NNP
cord-001835-0s7ok4uw	794	33	activity	activity	NN
cord-001835-0s7ok4uw	794	34	.	.	.
cord-001835-0s7ok4uw	795	1	Most	Most	JJS
cord-001835-0s7ok4uw	795	2	of	of	IN
cord-001835-0s7ok4uw	795	3	fish	fish	NN
cord-001835-0s7ok4uw	795	4	takes	take	VBZ
cord-001835-0s7ok4uw	795	5	crustacean	crustacean	NN
cord-001835-0s7ok4uw	795	6	such	such	JJ
cord-001835-0s7ok4uw	795	7	as	as	IN
cord-001835-0s7ok4uw	795	8	shrimp	shrimp	NN
cord-001835-0s7ok4uw	795	9	and	and	CC
cord-001835-0s7ok4uw	795	10	crab	crab	NN
cord-001835-0s7ok4uw	795	11	as	as	IN
cord-001835-0s7ok4uw	795	12	food	food	NN
cord-001835-0s7ok4uw	795	13	.	.	.
cord-001835-0s7ok4uw	796	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	796	2	,	,	,
cord-001835-0s7ok4uw	796	3	the	the	DT
cord-001835-0s7ok4uw	796	4	fish	fish	NN
cord-001835-0s7ok4uw	796	5	has	have	VBZ
cord-001835-0s7ok4uw	796	6	chitinase	chitinase	NN
cord-001835-0s7ok4uw	796	7	in	in	IN
cord-001835-0s7ok4uw	796	8	the	the	DT
cord-001835-0s7ok4uw	796	9	stomach	stomach	NN
cord-001835-0s7ok4uw	796	10	to	to	TO
cord-001835-0s7ok4uw	796	11	chemically	chemically	RB
cord-001835-0s7ok4uw	796	12	disrupt	disrupt	VB
cord-001835-0s7ok4uw	796	13	the	the	DT
cord-001835-0s7ok4uw	796	14	chitinous	chitinous	JJ
cord-001835-0s7ok4uw	796	15	envelope	envelope	NN
cord-001835-0s7ok4uw	796	16	of	of	IN
cord-001835-0s7ok4uw	796	17	crustacean	crustacean	NN
cord-001835-0s7ok4uw	796	18	.	.	.
cord-001835-0s7ok4uw	797	1	Four	four	CD
cord-001835-0s7ok4uw	797	2	chitinase	chitinase	NN
cord-001835-0s7ok4uw	797	3	isozymes	isozyme	NNS
cord-001835-0s7ok4uw	797	4	(	(	-LRB-
cord-001835-0s7ok4uw	797	5	42	42	CD
cord-001835-0s7ok4uw	797	6	-	-	SYM
cord-001835-0s7ok4uw	797	7	60	60	CD
cord-001835-0s7ok4uw	797	8	kDa	kDa	NNPS
cord-001835-0s7ok4uw	797	9	)	)	-RRB-
cord-001835-0s7ok4uw	797	10	,	,	,
cord-001835-0s7ok4uw	797	11	PaChiA	PaChiA	NNP
cord-001835-0s7ok4uw	797	12	[	[	-LRB-
cord-001835-0s7ok4uw	797	13	1	1	CD
cord-001835-0s7ok4uw	797	14	]	]	-RRB-
cord-001835-0s7ok4uw	797	15	and	and	CC
cord-001835-0s7ok4uw	797	16	PaChiB	PaChiB	NNP
cord-001835-0s7ok4uw	797	17	[	[	-LRB-
cord-001835-0s7ok4uw	797	18	2	2	CD
cord-001835-0s7ok4uw	797	19	]	]	-RRB-
cord-001835-0s7ok4uw	797	20	,	,	,
cord-001835-0s7ok4uw	797	21	and	and	CC
cord-001835-0s7ok4uw	797	22	PtChiA	PtChiA	NNP
cord-001835-0s7ok4uw	797	23	and	and	CC
cord-001835-0s7ok4uw	797	24	PtChiB	PtChiB	NNP
cord-001835-0s7ok4uw	797	25	,	,	,
cord-001835-0s7ok4uw	798	1	[	[	-LRB-
cord-001835-0s7ok4uw	798	2	3	3	CD
cord-001835-0s7ok4uw	798	3	]	]	-RRB-
cord-001835-0s7ok4uw	798	4	were	be	VBD
cord-001835-0s7ok4uw	798	5	purified	purify	VBN
cord-001835-0s7ok4uw	798	6	from	from	IN
cord-001835-0s7ok4uw	798	7	the	the	DT
cord-001835-0s7ok4uw	798	8	stomach	stomach	NN
cord-001835-0s7ok4uw	798	9	of	of	IN
cord-001835-0s7ok4uw	798	10	silver	silver	NN
cord-001835-0s7ok4uw	798	11	croaker	croaker	NN
cord-001835-0s7ok4uw	798	12	Pennahia	Pennahia	NNP
cord-001835-0s7ok4uw	798	13	argentatus	argentatus	NN
cord-001835-0s7ok4uw	798	14	and	and	CC
cord-001835-0s7ok4uw	798	15	threeline	threeline	NNP
cord-001835-0s7ok4uw	798	16	grunt	grunt	NNP
cord-001835-0s7ok4uw	799	1	Parapristipoma	Parapristipoma	NNP
cord-001835-0s7ok4uw	799	2	trilineatum	trilineatum	NN
cord-001835-0s7ok4uw	799	3	,	,	,
cord-001835-0s7ok4uw	799	4	by	by	IN
cord-001835-0s7ok4uw	799	5	ammonium	ammonium	NN
cord-001835-0s7ok4uw	799	6	sulfate	sulfate	NN
cord-001835-0s7ok4uw	799	7	fractionation	fractionation	NN
cord-001835-0s7ok4uw	799	8	and	and	CC
cord-001835-0s7ok4uw	799	9	column	column	NN
cord-001835-0s7ok4uw	799	10	chromatographies	chromatography	NNS
cord-001835-0s7ok4uw	799	11	,	,	,
cord-001835-0s7ok4uw	799	12	respectively	respectively	RB
cord-001835-0s7ok4uw	799	13	.	.	.
cord-001835-0s7ok4uw	800	1	All	all	PDT
cord-001835-0s7ok4uw	800	2	the	the	DT
cord-001835-0s7ok4uw	800	3	chitinases	chitinase	NNS
cord-001835-0s7ok4uw	800	4	were	be	VBD
cord-001835-0s7ok4uw	800	5	stable	stable	JJ
cord-001835-0s7ok4uw	800	6	and	and	CC
cord-001835-0s7ok4uw	800	7	showed	show	VBD
cord-001835-0s7ok4uw	800	8	activity	activity	NN
cord-001835-0s7ok4uw	800	9	in	in	IN
cord-001835-0s7ok4uw	800	10	the	the	DT
cord-001835-0s7ok4uw	800	11	acidic	acidic	JJ
cord-001835-0s7ok4uw	800	12	pH	ph	NN
cord-001835-0s7ok4uw	800	13	range	range	NN
cord-001835-0s7ok4uw	800	14	(	(	-LRB-
cord-001835-0s7ok4uw	800	15	pH3	ph3	NN
cord-001835-0s7ok4uw	800	16	-	-	HYPH
cord-001835-0s7ok4uw	800	17	5	5	CD
cord-001835-0s7ok4uw	800	18	)	)	-RRB-
cord-001835-0s7ok4uw	800	19	.	.	.
cord-001835-0s7ok4uw	801	1	PaChiA	PaChiA	NNP
cord-001835-0s7ok4uw	801	2	and	and	CC
cord-001835-0s7ok4uw	801	3	PtChiA	PtChiA	NNP
cord-001835-0s7ok4uw	801	4	preferentially	preferentially	RB
cord-001835-0s7ok4uw	801	5	degraded	degrade	VBD
cord-001835-0s7ok4uw	801	6	the	the	DT
cord-001835-0s7ok4uw	801	7	second	second	JJ
cord-001835-0s7ok4uw	801	8	glycosidic	glycosidic	JJ
cord-001835-0s7ok4uw	801	9	bond	bond	NN
cord-001835-0s7ok4uw	801	10	from	from	IN
cord-001835-0s7ok4uw	801	11	the	the	DT
cord-001835-0s7ok4uw	801	12	non	non	JJ
cord-001835-0s7ok4uw	801	13	-	-	JJ
cord-001835-0s7ok4uw	801	14	reducing	reducing	JJ
cord-001835-0s7ok4uw	801	15	end	end	NN
cord-001835-0s7ok4uw	801	16	of	of	IN
cord-001835-0s7ok4uw	801	17	(	(	-LRB-
cord-001835-0s7ok4uw	801	18	GlcNAc)n	GlcNAc)n	NNP
cord-001835-0s7ok4uw	801	19	and	and	CC
cord-001835-0s7ok4uw	801	20	PaChiB	PaChiB	NNP
cord-001835-0s7ok4uw	801	21	and	and	CC
cord-001835-0s7ok4uw	801	22	PtChiB	PtChiB	NNP
cord-001835-0s7ok4uw	801	23	had	have	VBD
cord-001835-0s7ok4uw	801	24	a	a	DT
cord-001835-0s7ok4uw	801	25	preference	preference	NN
cord-001835-0s7ok4uw	801	26	for	for	IN
cord-001835-0s7ok4uw	801	27	the	the	DT
cord-001835-0s7ok4uw	801	28	third	third	JJ
cord-001835-0s7ok4uw	801	29	glycosidic	glycosidic	JJ
cord-001835-0s7ok4uw	801	30	bond	bond	NN
cord-001835-0s7ok4uw	801	31	of	of	IN
cord-001835-0s7ok4uw	801	32	those	those	DT
cord-001835-0s7ok4uw	801	33	.	.	.
cord-001835-0s7ok4uw	802	1	All	all	PDT
cord-001835-0s7ok4uw	802	2	the	the	DT
cord-001835-0s7ok4uw	802	3	chitinases	chitinase	NNS
cord-001835-0s7ok4uw	802	4	showed	show	VBD
cord-001835-0s7ok4uw	802	5	different	different	JJ
cord-001835-0s7ok4uw	802	6	substrate	substrate	NN
cord-001835-0s7ok4uw	802	7	specificity	specificity	NN
cord-001835-0s7ok4uw	802	8	toward	toward	IN
cord-001835-0s7ok4uw	802	9	insoluble	insoluble	JJ
cord-001835-0s7ok4uw	802	10	long	long	JJ
cord-001835-0s7ok4uw	802	11	substrates	substrate	NNS
cord-001835-0s7ok4uw	802	12	.	.	.
cord-001835-0s7ok4uw	803	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	803	2	,	,	,
cord-001835-0s7ok4uw	803	3	chitinase	chitinase	NNP
cord-001835-0s7ok4uw	803	4	cDNAs	cDNAs	.
cord-001835-0s7ok4uw	804	1	(	(	-LRB-
cord-001835-0s7ok4uw	804	2	PaChi-1	pachi-1	VB
cord-001835-0s7ok4uw	804	3	and	and	CC
cord-001835-0s7ok4uw	804	4	PaChi-2	pachi-2	NN
cord-001835-0s7ok4uw	804	5	)	)	-RRB-
cord-001835-0s7ok4uw	804	6	encoding	encode	VBG
cord-001835-0s7ok4uw	804	7	PaChiA	PaChiA	NNP
cord-001835-0s7ok4uw	804	8	and	and	CC
cord-001835-0s7ok4uw	804	9	PaChiB	PaChiB	NNP
cord-001835-0s7ok4uw	804	10	,	,	,
cord-001835-0s7ok4uw	804	11	and	and	CC
cord-001835-0s7ok4uw	805	1	cDNAs	cDNAs	.
cord-001835-0s7ok4uw	806	1	(	(	-LRB-
cord-001835-0s7ok4uw	806	2	PtChi-1	PtChi-1	NNP
cord-001835-0s7ok4uw	806	3	and	and	CC
cord-001835-0s7ok4uw	806	4	PtChi-2	PtChi-2	NNP
cord-001835-0s7ok4uw	806	5	)	)	-RRB-
cord-001835-0s7ok4uw	807	1	encoding	encode	VBG
cord-001835-0s7ok4uw	807	2	PtChiA	PtChiA	NNP
cord-001835-0s7ok4uw	807	3	and	and	CC
cord-001835-0s7ok4uw	807	4	PtChiB	PtChiB	NNP
cord-001835-0s7ok4uw	807	5	were	be	VBD
cord-001835-0s7ok4uw	807	6	obtained	obtain	VBN
cord-001835-0s7ok4uw	807	7	by	by	IN
cord-001835-0s7ok4uw	807	8	cDNA	cdna	NN
cord-001835-0s7ok4uw	807	9	cloning	cloning	NN
cord-001835-0s7ok4uw	807	10	using	use	VBG
cord-001835-0s7ok4uw	807	11	the	the	DT
cord-001835-0s7ok4uw	807	12	RT	RT	NNP
cord-001835-0s7ok4uw	807	13	-	-	HYPH
cord-001835-0s7ok4uw	807	14	PCR	PCR	NNP
cord-001835-0s7ok4uw	807	15	and	and	CC
cord-001835-0s7ok4uw	807	16	RACE	race	NN
cord-001835-0s7ok4uw	807	17	method	method	NN
cord-001835-0s7ok4uw	807	18	.	.	.
cord-001835-0s7ok4uw	808	1	The	the	DT
cord-001835-0s7ok4uw	808	2	deduced	deduce	VBN
cord-001835-0s7ok4uw	808	3	amino	amino	NN
cord-001835-0s7ok4uw	808	4	acid	acid	NN
cord-001835-0s7ok4uw	808	5	sequences	sequence	NNS
cord-001835-0s7ok4uw	808	6	of	of	IN
cord-001835-0s7ok4uw	808	7	all	all	PDT
cord-001835-0s7ok4uw	808	8	the	the	DT
cord-001835-0s7ok4uw	808	9	chitinase	chitinase	NNP
cord-001835-0s7ok4uw	808	10	cDNAs	cDNAs	NNPS
cord-001835-0s7ok4uw	808	11	contained	contain	VBD
cord-001835-0s7ok4uw	808	12	N	n	CD
cord-001835-0s7ok4uw	808	13	-	-	HYPH
cord-001835-0s7ok4uw	808	14	terminal	terminal	NN
cord-001835-0s7ok4uw	808	15	signal	signal	NN
cord-001835-0s7ok4uw	808	16	peptide	peptide	NN
cord-001835-0s7ok4uw	808	17	,	,	,
cord-001835-0s7ok4uw	808	18	GH	GH	NNP
cord-001835-0s7ok4uw	808	19	family	family	NN
cord-001835-0s7ok4uw	808	20	18	18	CD
cord-001835-0s7ok4uw	808	21	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	808	22	domain	domain	NN
cord-001835-0s7ok4uw	808	23	,	,	,
cord-001835-0s7ok4uw	808	24	linker	linker	NN
cord-001835-0s7ok4uw	808	25	region	region	NN
cord-001835-0s7ok4uw	808	26	,	,	,
cord-001835-0s7ok4uw	808	27	and	and	CC
cord-001835-0s7ok4uw	808	28	chitin	chitin	NN
cord-001835-0s7ok4uw	808	29	-	-	HYPH
cord-001835-0s7ok4uw	808	30	binding	bind	VBG
cord-001835-0s7ok4uw	808	31	domain	domain	NN
cord-001835-0s7ok4uw	808	32	.	.	.
cord-001835-0s7ok4uw	809	1	Phylogenetic	phylogenetic	JJ
cord-001835-0s7ok4uw	809	2	tree	tree	NN
cord-001835-0s7ok4uw	809	3	analysis	analysis	NN
cord-001835-0s7ok4uw	809	4	of	of	IN
cord-001835-0s7ok4uw	809	5	vertebrate	vertebrate	NNP
cord-001835-0s7ok4uw	809	6	chitinase	chitinase	NNP
cord-001835-0s7ok4uw	809	7	revealed	reveal	VBD
cord-001835-0s7ok4uw	809	8	that	that	IN
cord-001835-0s7ok4uw	809	9	fish	fish	NN
cord-001835-0s7ok4uw	809	10	stomach	stomach	NN
cord-001835-0s7ok4uw	809	11	chitinases	chitinase	NNS
cord-001835-0s7ok4uw	809	12	form	form	VBP
cord-001835-0s7ok4uw	809	13	unique	unique	JJ
cord-001835-0s7ok4uw	809	14	chitinase	chitinase	NNP
cord-001835-0s7ok4uw	809	15	isozyme	isozyme	NNP
cord-001835-0s7ok4uw	809	16	groups	group	NNS
cord-001835-0s7ok4uw	809	17	,	,	,
cord-001835-0s7ok4uw	809	18	acidic	acidic	JJ
cord-001835-0s7ok4uw	809	19	fish	fish	NN
cord-001835-0s7ok4uw	809	20	chitinase-1	chitinase-1	NNP
cord-001835-0s7ok4uw	809	21	(	(	-LRB-
cord-001835-0s7ok4uw	809	22	AFCase-1	afcase-1	NN
cord-001835-0s7ok4uw	809	23	)	)	-RRB-
cord-001835-0s7ok4uw	809	24	including	include	VBG
cord-001835-0s7ok4uw	809	25	PaChiA	PaChiA	NNP
cord-001835-0s7ok4uw	809	26	and	and	CC
cord-001835-0s7ok4uw	809	27	PtChiA	PtChiA	NNP
cord-001835-0s7ok4uw	809	28	,	,	,
cord-001835-0s7ok4uw	809	29	and	and	CC
cord-001835-0s7ok4uw	809	30	acidic	acidic	JJ
cord-001835-0s7ok4uw	809	31	fish	fish	NN
cord-001835-0s7ok4uw	809	32	chitinase-2	chitinase-2	NNP
cord-001835-0s7ok4uw	810	1	(	(	-LRB-
cord-001835-0s7ok4uw	810	2	AFCase-2	afcase-2	NN
cord-001835-0s7ok4uw	810	3	)	)	-RRB-
cord-001835-0s7ok4uw	810	4	including	include	VBG
cord-001835-0s7ok4uw	810	5	PaChiB	PaChiB	NNP
cord-001835-0s7ok4uw	810	6	and	and	CC
cord-001835-0s7ok4uw	810	7	PtChiB	PtChiB	NNP
cord-001835-0s7ok4uw	810	8	,	,	,
cord-001835-0s7ok4uw	810	9	which	which	WDT
cord-001835-0s7ok4uw	810	10	was	be	VBD
cord-001835-0s7ok4uw	810	11	different	different	JJ
cord-001835-0s7ok4uw	810	12	from	from	IN
cord-001835-0s7ok4uw	810	13	an	an	DT
cord-001835-0s7ok4uw	810	14	acidic	acidic	JJ
cord-001835-0s7ok4uw	810	15	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	810	16	chitinase	chitinase	NN
cord-001835-0s7ok4uw	810	17	(	(	-LRB-
cord-001835-0s7ok4uw	810	18	AMCase	AMCase	NNP
cord-001835-0s7ok4uw	810	19	)	)	-RRB-
cord-001835-0s7ok4uw	810	20	group	group	NN
cord-001835-0s7ok4uw	810	21	.	.	.
cord-001835-0s7ok4uw	811	1	[	[	-LRB-
cord-001835-0s7ok4uw	811	2	3	3	CD
cord-001835-0s7ok4uw	811	3	,	,	,
cord-001835-0s7ok4uw	811	4	4	4	CD
cord-001835-0s7ok4uw	811	5	]	]	-RRB-
cord-001835-0s7ok4uw	812	1	The	the	DT
cord-001835-0s7ok4uw	812	2	previously	previously	RB
cord-001835-0s7ok4uw	812	3	reported	report	VBN
cord-001835-0s7ok4uw	812	4	purified	purify	VBN
cord-001835-0s7ok4uw	812	5	fish	fish	NN
cord-001835-0s7ok4uw	812	6	stomach	stomach	NN
cord-001835-0s7ok4uw	812	7	chitinases	chitinase	NNS
cord-001835-0s7ok4uw	812	8	[	[	-LRB-
cord-001835-0s7ok4uw	812	9	5	5	CD
cord-001835-0s7ok4uw	812	10	]	]	-RRB-
cord-001835-0s7ok4uw	812	11	can	can	MD
cord-001835-0s7ok4uw	812	12	also	also	RB
cord-001835-0s7ok4uw	812	13	be	be	VB
cord-001835-0s7ok4uw	812	14	classified	classify	VBN
cord-001835-0s7ok4uw	812	15	into	into	IN
cord-001835-0s7ok4uw	812	16	two	two	CD
cord-001835-0s7ok4uw	812	17	chitinase	chitinase	NNP
cord-001835-0s7ok4uw	812	18	isozyme	isozyme	NNP
cord-001835-0s7ok4uw	812	19	groups	group	NNS
cord-001835-0s7ok4uw	812	20	,	,	,
cord-001835-0s7ok4uw	812	21	AFCase-1	AFCase-1	NNP
cord-001835-0s7ok4uw	812	22	and	and	CC
cord-001835-0s7ok4uw	812	23	AFCase-2	AFCase-2	NNP
cord-001835-0s7ok4uw	812	24	,	,	,
cord-001835-0s7ok4uw	812	25	by	by	IN
cord-001835-0s7ok4uw	812	26	the	the	DT
cord-001835-0s7ok4uw	812	27	N	n	CD
cord-001835-0s7ok4uw	812	28	-	-	HYPH
cord-001835-0s7ok4uw	812	29	terminal	terminal	NN
cord-001835-0s7ok4uw	812	30	amino	amino	NN
cord-001835-0s7ok4uw	812	31	acid	acid	NN
cord-001835-0s7ok4uw	812	32	sequence	sequence	NN
cord-001835-0s7ok4uw	812	33	.	.	.
cord-001835-0s7ok4uw	813	1	This	this	DT
cord-001835-0s7ok4uw	813	2	study	study	NN
cord-001835-0s7ok4uw	813	3	suggested	suggest	VBD
cord-001835-0s7ok4uw	813	4	that	that	IN
cord-001835-0s7ok4uw	813	5	fish	fish	NN
cord-001835-0s7ok4uw	813	6	have	have	VBP
cord-001835-0s7ok4uw	813	7	excellent	excellent	JJ
cord-001835-0s7ok4uw	813	8	chitin	chitin	NN
cord-001835-0s7ok4uw	813	9	degrading	degrade	VBG
cord-001835-0s7ok4uw	813	10	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	813	11	system	system	NN
cord-001835-0s7ok4uw	813	12	in	in	IN
cord-001835-0s7ok4uw	813	13	which	which	WDT
cord-001835-0s7ok4uw	813	14	two	two	CD
cord-001835-0s7ok4uw	813	15	different	different	JJ
cord-001835-0s7ok4uw	813	16	chitinases	chitinase	NNS
cord-001835-0s7ok4uw	813	17	isozyme	isozyme	NNS
cord-001835-0s7ok4uw	813	18	groups	group	NNS
cord-001835-0s7ok4uw	813	19	,	,	,
cord-001835-0s7ok4uw	813	20	AFCase-1	AFCase-1	NNP
cord-001835-0s7ok4uw	813	21	and	and	CC
cord-001835-0s7ok4uw	813	22	AFCase-2	AFCase-2	NNP
cord-001835-0s7ok4uw	813	23	,	,	,
cord-001835-0s7ok4uw	813	24	with	with	IN
cord-001835-0s7ok4uw	813	25	different	different	JJ
cord-001835-0s7ok4uw	813	26	degradation	degradation	NN
cord-001835-0s7ok4uw	813	27	patterns	pattern	NNS
cord-001835-0s7ok4uw	813	28	are	be	VBP
cord-001835-0s7ok4uw	813	29	expressed	express	VBN
cord-001835-0s7ok4uw	813	30	in	in	IN
cord-001835-0s7ok4uw	813	31	the	the	DT
cord-001835-0s7ok4uw	813	32	stomach	stomach	NN
cord-001835-0s7ok4uw	813	33	.	.	.
cord-001835-0s7ok4uw	814	1	Recently	recently	RB
cord-001835-0s7ok4uw	814	2	,	,	,
cord-001835-0s7ok4uw	814	3	the	the	DT
cord-001835-0s7ok4uw	814	4	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	814	5	produced	produce	VBN
cord-001835-0s7ok4uw	814	6	by	by	IN
cord-001835-0s7ok4uw	814	7	psychrophilic	psychrophilic	NNP
cord-001835-0s7ok4uw	814	8	organisms	organism	NNS
cord-001835-0s7ok4uw	814	9	have	have	VBP
cord-001835-0s7ok4uw	814	10	gained	gain	VBN
cord-001835-0s7ok4uw	814	11	huge	huge	JJ
cord-001835-0s7ok4uw	814	12	interest	interest	NN
cord-001835-0s7ok4uw	814	13	especially	especially	RB
cord-001835-0s7ok4uw	814	14	in	in	IN
cord-001835-0s7ok4uw	814	15	the	the	DT
cord-001835-0s7ok4uw	814	16	studies	study	NNS
cord-001835-0s7ok4uw	814	17	of	of	IN
cord-001835-0s7ok4uw	814	18	temperature	temperature	NN
cord-001835-0s7ok4uw	814	19	adaptation	adaptation	NN
cord-001835-0s7ok4uw	814	20	of	of	IN
cord-001835-0s7ok4uw	814	21	the	the	DT
cord-001835-0s7ok4uw	814	22	protein	protein	NN
cord-001835-0s7ok4uw	814	23	.	.	.
cord-001835-0s7ok4uw	815	1	Previously	previously	RB
cord-001835-0s7ok4uw	815	2	,	,	,
cord-001835-0s7ok4uw	815	3	a	a	DT
cord-001835-0s7ok4uw	815	4	cold	cold	NN
cord-001835-0s7ok4uw	815	5	-	-	HYPH
cord-001835-0s7ok4uw	815	6	adapted	adapt	VBN
cord-001835-0s7ok4uw	815	7	yeast	yeast	NN
cord-001835-0s7ok4uw	815	8	,	,	,
cord-001835-0s7ok4uw	815	9	Glaciozyma	Glaciozyma	NNP
cord-001835-0s7ok4uw	815	10	antarctica	antarctica	NNP
cord-001835-0s7ok4uw	815	11	PI12	PI12	NNP
cord-001835-0s7ok4uw	815	12	was	be	VBD
cord-001835-0s7ok4uw	815	13	isolated	isolate	VBN
cord-001835-0s7ok4uw	815	14	from	from	IN
cord-001835-0s7ok4uw	815	15	a	a	DT
cord-001835-0s7ok4uw	815	16	marine	marine	JJ
cord-001835-0s7ok4uw	815	17	environment	environment	NN
cord-001835-0s7ok4uw	815	18	in	in	IN
cord-001835-0s7ok4uw	815	19	Antarctica	Antarctica	NNP
cord-001835-0s7ok4uw	815	20	and	and	CC
cord-001835-0s7ok4uw	815	21	the	the	DT
cord-001835-0s7ok4uw	815	22	yeast	yeast	NN
cord-001835-0s7ok4uw	815	23	was	be	VBD
cord-001835-0s7ok4uw	815	24	known	know	VBN
cord-001835-0s7ok4uw	815	25	to	to	TO
cord-001835-0s7ok4uw	815	26	produce	produce	VB
cord-001835-0s7ok4uw	815	27	lipolytic	lipolytic	JJ
cord-001835-0s7ok4uw	815	28	and	and	CC
cord-001835-0s7ok4uw	815	29	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	815	30	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	815	31	.	.	.
cord-001835-0s7ok4uw	816	1	A	a	DT
cord-001835-0s7ok4uw	816	2	gene	gene	NN
cord-001835-0s7ok4uw	816	3	encoding	encode	VBG
cord-001835-0s7ok4uw	816	4	a	a	DT
cord-001835-0s7ok4uw	816	5	unique	unique	JJ
cord-001835-0s7ok4uw	816	6	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	816	7	bifunctional	bifunctional	JJ
cord-001835-0s7ok4uw	816	8	enzyme	enzyme	NN
cord-001835-0s7ok4uw	816	9	(	(	-LRB-
cord-001835-0s7ok4uw	816	10	LipPI12	LipPI12	NNP
cord-001835-0s7ok4uw	816	11	)	)	-RRB-
cord-001835-0s7ok4uw	816	12	with	with	IN
cord-001835-0s7ok4uw	816	13	cold	cold	JJ
cord-001835-0s7ok4uw	816	14	active	active	JJ
cord-001835-0s7ok4uw	816	15	lipase	lipase	NN
cord-001835-0s7ok4uw	816	16	with	with	IN
cord-001835-0s7ok4uw	816	17	protease	protease	NN
cord-001835-0s7ok4uw	816	18	activity	activity	NN
cord-001835-0s7ok4uw	816	19	was	be	VBD
cord-001835-0s7ok4uw	816	20	successfully	successfully	RB
cord-001835-0s7ok4uw	816	21	expressed	express	VBN
cord-001835-0s7ok4uw	816	22	,	,	,
cord-001835-0s7ok4uw	816	23	purified	purify	VBN
cord-001835-0s7ok4uw	816	24	and	and	CC
cord-001835-0s7ok4uw	816	25	characterized	characterize	VBN
cord-001835-0s7ok4uw	816	26	.	.	.
cord-001835-0s7ok4uw	817	1	Temperature	temperature	NN
cord-001835-0s7ok4uw	817	2	profile	profile	NN
cord-001835-0s7ok4uw	817	3	of	of	IN
cord-001835-0s7ok4uw	817	4	the	the	DT
cord-001835-0s7ok4uw	817	5	bifunctional	bifunctional	JJ
cord-001835-0s7ok4uw	817	6	LipPI12	LipPI12	NNP
cord-001835-0s7ok4uw	817	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	817	8	showed	show	VBD
cord-001835-0s7ok4uw	817	9	that	that	IN
cord-001835-0s7ok4uw	817	10	the	the	DT
cord-001835-0s7ok4uw	817	11	lipase	lipase	NN
cord-001835-0s7ok4uw	817	12	functions	function	NNS
cord-001835-0s7ok4uw	817	13	optimally	optimally	RB
cord-001835-0s7ok4uw	817	14	at	at	IN
cord-001835-0s7ok4uw	817	15	208C	208c	CD
cord-001835-0s7ok4uw	817	16	whereas	whereas	IN
cord-001835-0s7ok4uw	817	17	the	the	DT
cord-001835-0s7ok4uw	817	18	protease	protease	NN
cord-001835-0s7ok4uw	817	19	was	be	VBD
cord-001835-0s7ok4uw	817	20	more	more	RBR
cord-001835-0s7ok4uw	817	21	active	active	JJ
cord-001835-0s7ok4uw	817	22	at	at	IN
cord-001835-0s7ok4uw	817	23	408C.	408c.	CD
cord-001835-0s7ok4uw	817	24	pH	pH	NNP
cord-001835-0s7ok4uw	817	25	profile	profile	NN
cord-001835-0s7ok4uw	817	26	showed	show	VBD
cord-001835-0s7ok4uw	817	27	that	that	IN
cord-001835-0s7ok4uw	817	28	both	both	DT
cord-001835-0s7ok4uw	817	29	LipPI12	LipPI12	NNP
cord-001835-0s7ok4uw	817	30	lipase	lipase	NN
cord-001835-0s7ok4uw	817	31	and	and	CC
cord-001835-0s7ok4uw	817	32	protease	protease	NN
cord-001835-0s7ok4uw	817	33	were	be	VBD
cord-001835-0s7ok4uw	817	34	active	active	JJ
cord-001835-0s7ok4uw	817	35	at	at	IN
cord-001835-0s7ok4uw	817	36	near	near	IN
cord-001835-0s7ok4uw	817	37	neutral	neutral	JJ
cord-001835-0s7ok4uw	817	38	condition	condition	NN
cord-001835-0s7ok4uw	817	39	.	.	.
cord-001835-0s7ok4uw	818	1	Activity	activity	NN
cord-001835-0s7ok4uw	818	2	of	of	IN
cord-001835-0s7ok4uw	818	3	LipPI12	LipPI12	NNP
cord-001835-0s7ok4uw	818	4	lipase	lipase	NN
cord-001835-0s7ok4uw	818	5	and	and	CC
cord-001835-0s7ok4uw	818	6	protease	protease	NN
cord-001835-0s7ok4uw	818	7	were	be	VBD
cord-001835-0s7ok4uw	818	8	also	also	RB
cord-001835-0s7ok4uw	818	9	activated	activate	VBN
cord-001835-0s7ok4uw	818	10	in	in	IN
cord-001835-0s7ok4uw	818	11	the	the	DT
cord-001835-0s7ok4uw	818	12	presence	presence	NN
cord-001835-0s7ok4uw	818	13	of	of	IN
cord-001835-0s7ok4uw	818	14	CaCl2	cacl2	NN
cord-001835-0s7ok4uw	818	15	but	but	CC
cord-001835-0s7ok4uw	818	16	its	-PRON-	PRP$
cord-001835-0s7ok4uw	818	17	protease	protease	NN
cord-001835-0s7ok4uw	818	18	counterpart	counterpart	NN
cord-001835-0s7ok4uw	818	19	seemed	seem	VBD
cord-001835-0s7ok4uw	818	20	to	to	TO
cord-001835-0s7ok4uw	818	21	be	be	VB
cord-001835-0s7ok4uw	818	22	more	more	RBR
cord-001835-0s7ok4uw	818	23	active	active	JJ
cord-001835-0s7ok4uw	818	24	in	in	IN
cord-001835-0s7ok4uw	818	25	the	the	DT
cord-001835-0s7ok4uw	818	26	presence	presence	NN
cord-001835-0s7ok4uw	818	27	of	of	IN
cord-001835-0s7ok4uw	818	28	ZnCl2	zncl2	NN
cord-001835-0s7ok4uw	818	29	.	.	.
cord-001835-0s7ok4uw	819	1	Effect	effect	NN
cord-001835-0s7ok4uw	819	2	of	of	IN
cord-001835-0s7ok4uw	819	3	surfactants	surfactant	NNS
cord-001835-0s7ok4uw	819	4	showed	show	VBD
cord-001835-0s7ok4uw	819	5	LipPI12	LipPI12	NNP
cord-001835-0s7ok4uw	819	6	lipase	lipase	NN
cord-001835-0s7ok4uw	819	7	was	be	VBD
cord-001835-0s7ok4uw	819	8	activated	activate	VBN
cord-001835-0s7ok4uw	819	9	by	by	IN
cord-001835-0s7ok4uw	819	10	Tween	Tween	NNP
cord-001835-0s7ok4uw	819	11	80	80	CD
cord-001835-0s7ok4uw	819	12	and	and	CC
cord-001835-0s7ok4uw	819	13	SLS	SLS	NNP
cord-001835-0s7ok4uw	819	14	and	and	CC
cord-001835-0s7ok4uw	819	15	in	in	IN
cord-001835-0s7ok4uw	819	16	contrast	contrast	NN
cord-001835-0s7ok4uw	819	17	,	,	,
cord-001835-0s7ok4uw	819	18	LipPI12	LipPI12	NNP
cord-001835-0s7ok4uw	819	19	protease	protease	NN
cord-001835-0s7ok4uw	819	20	was	be	VBD
cord-001835-0s7ok4uw	819	21	almost	almost	RB
cord-001835-0s7ok4uw	819	22	deactivated	deactivate	VBN
cord-001835-0s7ok4uw	819	23	in	in	IN
cord-001835-0s7ok4uw	819	24	all	all	DT
cord-001835-0s7ok4uw	819	25	surfactants	surfactant	NNS
cord-001835-0s7ok4uw	819	26	tested	test	VBN
cord-001835-0s7ok4uw	819	27	.	.	.
cord-001835-0s7ok4uw	820	1	The	the	DT
cord-001835-0s7ok4uw	820	2	presence	presence	NN
cord-001835-0s7ok4uw	820	3	of	of	IN
cord-001835-0s7ok4uw	820	4	organic	organic	JJ
cord-001835-0s7ok4uw	820	5	solvents	solvent	NNS
cord-001835-0s7ok4uw	820	6	did	do	VBD
cord-001835-0s7ok4uw	820	7	not	not	RB
cord-001835-0s7ok4uw	820	8	affect	affect	VB
cord-001835-0s7ok4uw	820	9	both	both	CC
cord-001835-0s7ok4uw	820	10	the	the	DT
cord-001835-0s7ok4uw	820	11	lipase	lipase	NN
cord-001835-0s7ok4uw	820	12	and	and	CC
cord-001835-0s7ok4uw	820	13	protease	protease	NN
cord-001835-0s7ok4uw	820	14	activities	activity	NNS
cord-001835-0s7ok4uw	820	15	.	.	.
cord-001835-0s7ok4uw	821	1	The	the	DT
cord-001835-0s7ok4uw	821	2	lipase	lipase	NN
cord-001835-0s7ok4uw	821	3	was	be	VBD
cord-001835-0s7ok4uw	821	4	more	more	RBR
cord-001835-0s7ok4uw	821	5	stable	stable	JJ
cord-001835-0s7ok4uw	821	6	at	at	IN
cord-001835-0s7ok4uw	821	7	solvents	solvent	NNS
cord-001835-0s7ok4uw	821	8	with	with	IN
cord-001835-0s7ok4uw	821	9	higher	high	JJR
cord-001835-0s7ok4uw	821	10	log	log	NN
cord-001835-0s7ok4uw	821	11	P	p	NN
cord-001835-0s7ok4uw	821	12	value	value	NN
cord-001835-0s7ok4uw	821	13	whereas	whereas	IN
cord-001835-0s7ok4uw	821	14	the	the	DT
cord-001835-0s7ok4uw	821	15	protease	protease	NN
cord-001835-0s7ok4uw	821	16	was	be	VBD
cord-001835-0s7ok4uw	821	17	slightly	slightly	RB
cord-001835-0s7ok4uw	821	18	activated	activate	VBN
cord-001835-0s7ok4uw	821	19	at	at	IN
cord-001835-0s7ok4uw	821	20	low	low	JJ
cord-001835-0s7ok4uw	821	21	log	log	NN
cord-001835-0s7ok4uw	821	22	P	p	NN
cord-001835-0s7ok4uw	821	23	value	value	NN
cord-001835-0s7ok4uw	821	24	particularly	particularly	RB
cord-001835-0s7ok4uw	821	25	with	with	IN
cord-001835-0s7ok4uw	821	26	dimethylsulfonyl	dimethylsulfonyl	NN
cord-001835-0s7ok4uw	821	27	.	.	.
cord-001835-0s7ok4uw	822	1	Inhibitor	Inhibitor	NNP
cord-001835-0s7ok4uw	822	2	studies	study	NNS
cord-001835-0s7ok4uw	822	3	revealed	reveal	VBD
cord-001835-0s7ok4uw	822	4	that	that	IN
cord-001835-0s7ok4uw	822	5	LipPI12	LipPI12	NNP
cord-001835-0s7ok4uw	822	6	lipase	lipase	NN
cord-001835-0s7ok4uw	822	7	was	be	VBD
cord-001835-0s7ok4uw	822	8	partially	partially	RB
cord-001835-0s7ok4uw	822	9	inhibited	inhibit	VBN
cord-001835-0s7ok4uw	822	10	with	with	IN
cord-001835-0s7ok4uw	822	11	EDTA	EDTA	NNP
cord-001835-0s7ok4uw	822	12	and	and	CC
cord-001835-0s7ok4uw	822	13	PMSF	PMSF	NNP
cord-001835-0s7ok4uw	822	14	whereby	whereby	WRB
cord-001835-0s7ok4uw	822	15	the	the	DT
cord-001835-0s7ok4uw	822	16	LipPI12	LipPI12	NNP
cord-001835-0s7ok4uw	822	17	protease	protease	NN
cord-001835-0s7ok4uw	822	18	was	be	VBD
cord-001835-0s7ok4uw	822	19	inhibited	inhibit	VBN
cord-001835-0s7ok4uw	822	20	by	by	IN
cord-001835-0s7ok4uw	822	21	pepstatin	pepstatin	NNP
cord-001835-0s7ok4uw	822	22	,	,	,
cord-001835-0s7ok4uw	822	23	EDTA	EDTA	NNP
cord-001835-0s7ok4uw	822	24	and	and	CC
cord-001835-0s7ok4uw	822	25	PMSF	PMSF	NNP
cord-001835-0s7ok4uw	822	26	.	.	.
cord-001835-0s7ok4uw	823	1	LipPI12	lippi12	NN
cord-001835-0s7ok4uw	823	2	enzyme	enzyme	NN
cord-001835-0s7ok4uw	823	3	was	be	VBD
cord-001835-0s7ok4uw	823	4	successfully	successfully	RB
cord-001835-0s7ok4uw	823	5	crystallized	crystallize	VBN
cord-001835-0s7ok4uw	823	6	via	via	IN
cord-001835-0s7ok4uw	823	7	vapour	vapour	NN
cord-001835-0s7ok4uw	823	8	diffusion	diffusion	NN
cord-001835-0s7ok4uw	823	9	method	method	NN
cord-001835-0s7ok4uw	823	10	.	.	.
cord-001835-0s7ok4uw	824	1	Crystal	Crystal	NNP
cord-001835-0s7ok4uw	824	2	of	of	IN
cord-001835-0s7ok4uw	824	3	LipPI12	LipPI12	NNP
cord-001835-0s7ok4uw	824	4	enzyme	enzyme	NN
cord-001835-0s7ok4uw	824	5	was	be	VBD
cord-001835-0s7ok4uw	824	6	diffracted	diffract	VBN
cord-001835-0s7ok4uw	824	7	via	via	IN
cord-001835-0s7ok4uw	824	8	synchrotron	synchrotron	NN
cord-001835-0s7ok4uw	824	9	radiation	radiation	NN
cord-001835-0s7ok4uw	824	10	.	.	.
cord-001835-0s7ok4uw	825	1	The	the	DT
cord-001835-0s7ok4uw	825	2	three	three	CD
cord-001835-0s7ok4uw	825	3	-	-	HYPH
cord-001835-0s7ok4uw	825	4	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	825	5	structure	structure	NN
cord-001835-0s7ok4uw	825	6	of	of	IN
cord-001835-0s7ok4uw	825	7	cold	cold	NN
cord-001835-0s7ok4uw	825	8	-	-	HYPH
cord-001835-0s7ok4uw	825	9	adapted	adapt	VBN
cord-001835-0s7ok4uw	825	10	PI12	PI12	NNP
cord-001835-0s7ok4uw	825	11	provided	provide	VBD
cord-001835-0s7ok4uw	825	12	insight	insight	NN
cord-001835-0s7ok4uw	825	13	into	into	IN
cord-001835-0s7ok4uw	825	14	cold	cold	JJ
cord-001835-0s7ok4uw	825	15	adaptation	adaptation	NN
cord-001835-0s7ok4uw	825	16	and	and	CC
cord-001835-0s7ok4uw	825	17	better	well	JJR
cord-001835-0s7ok4uw	825	18	understanding	understanding	NN
cord-001835-0s7ok4uw	825	19	of	of	IN
cord-001835-0s7ok4uw	825	20	the	the	DT
cord-001835-0s7ok4uw	825	21	structural	structural	JJ
cord-001835-0s7ok4uw	825	22	properties	property	NNS
cord-001835-0s7ok4uw	825	23	of	of	IN
cord-001835-0s7ok4uw	825	24	LipPI12	LipPI12	NNP
cord-001835-0s7ok4uw	825	25	enzyme	enzyme	NN
cord-001835-0s7ok4uw	825	26	.	.	.
cord-001835-0s7ok4uw	826	1	The	the	DT
cord-001835-0s7ok4uw	826	2	bifunctional	bifunctional	JJ
cord-001835-0s7ok4uw	826	3	properties	property	NNS
cord-001835-0s7ok4uw	826	4	of	of	IN
cord-001835-0s7ok4uw	826	5	the	the	DT
cord-001835-0s7ok4uw	826	6	enzyme	enzyme	NN
cord-001835-0s7ok4uw	826	7	could	could	MD
cord-001835-0s7ok4uw	826	8	be	be	VB
cord-001835-0s7ok4uw	826	9	potential	potential	JJ
cord-001835-0s7ok4uw	826	10	candidate	candidate	NN
cord-001835-0s7ok4uw	826	11	for	for	IN
cord-001835-0s7ok4uw	826	12	low	low	JJ
cord-001835-0s7ok4uw	826	13	temperature	temperature	NN
cord-001835-0s7ok4uw	826	14	industrial	industrial	JJ
cord-001835-0s7ok4uw	826	15	application	application	NN
cord-001835-0s7ok4uw	826	16	.	.	.
cord-001835-0s7ok4uw	827	1	Conformation	conformation	NN
cord-001835-0s7ok4uw	827	2	-	-	HYPH
cord-001835-0s7ok4uw	827	3	specific	specific	JJ
cord-001835-0s7ok4uw	827	4	antibodies	antibody	NNS
cord-001835-0s7ok4uw	827	5	as	as	IN
cord-001835-0s7ok4uw	827	6	enhancers	enhancer	NNS
cord-001835-0s7ok4uw	827	7	and	and	CC
cord-001835-0s7ok4uw	827	8	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	827	9	of	of	IN
cord-001835-0s7ok4uw	827	10	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	827	11	activity	activity	NN
cord-001835-0s7ok4uw	827	12	of	of	IN
cord-001835-0s7ok4uw	827	13	DEP	DEP	NNP
cord-001835-0s7ok4uw	827	14	1	1	CD
cord-001835-0s7ok4uw	827	15	Malgorzata	Malgorzata	NNP
cord-001835-0s7ok4uw	827	16	Nocula	Nocula	NNP
cord-001835-0s7ok4uw	827	17	-	-	HYPH
cord-001835-0s7ok4uw	827	18	Lugowska	Lugowska	NNP
cord-001835-0s7ok4uw	827	19	1	1	CD
cord-001835-0s7ok4uw	827	20	,	,	,
cord-001835-0s7ok4uw	827	21	Mateusz	Mateusz	NNP
cord-001835-0s7ok4uw	827	22	Lugowski	Lugowski	NNP
cord-001835-0s7ok4uw	827	23	1	1	CD
cord-001835-0s7ok4uw	828	1	,	,	,
cord-001835-0s7ok4uw	828	2	Anthony	Anthony	NNP
cord-001835-0s7ok4uw	828	3	A.	a.	NN
cord-001835-0s7ok4uw	828	4	Kossiakoff	Kossiakoff	NNP
cord-001835-0s7ok4uw	828	5	1	1	CD
cord-001835-0s7ok4uw	828	6	1	1	CD
cord-001835-0s7ok4uw	829	1	The	the	DT
cord-001835-0s7ok4uw	829	2	University	University	NNP
cord-001835-0s7ok4uw	829	3	of	of	IN
cord-001835-0s7ok4uw	829	4	Chicago	Chicago	NNP
cord-001835-0s7ok4uw	829	5	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	830	1	(	(	-LRB-
cord-001835-0s7ok4uw	830	2	CD148	CD148	NNP
cord-001835-0s7ok4uw	830	3	/	/	SYM
cord-001835-0s7ok4uw	830	4	PTP	PTP	NNP
cord-001835-0s7ok4uw	830	5	-	-	HYPH
cord-001835-0s7ok4uw	830	6	h	h	NNP
cord-001835-0s7ok4uw	830	7	)	)	-RRB-
cord-001835-0s7ok4uw	830	8	is	be	VBZ
cord-001835-0s7ok4uw	830	9	a	a	DT
cord-001835-0s7ok4uw	830	10	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	830	11	receptor	receptor	NN
cord-001835-0s7ok4uw	830	12	-	-	HYPH
cord-001835-0s7ok4uw	830	13	like	like	JJ
cord-001835-0s7ok4uw	830	14	protein	protein	NN
cord-001835-0s7ok4uw	830	15	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	830	16	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	830	17	(	(	-LRB-
cord-001835-0s7ok4uw	830	18	PTP	PTP	NNP
cord-001835-0s7ok4uw	830	19	)	)	-RRB-
cord-001835-0s7ok4uw	830	20	that	that	WDT
cord-001835-0s7ok4uw	830	21	has	have	VBZ
cord-001835-0s7ok4uw	830	22	been	be	VBN
cord-001835-0s7ok4uw	830	23	implicated	implicate	VBN
cord-001835-0s7ok4uw	830	24	in	in	IN
cord-001835-0s7ok4uw	830	25	the	the	DT
cord-001835-0s7ok4uw	830	26	density	density	NN
cord-001835-0s7ok4uw	830	27	-	-	HYPH
cord-001835-0s7ok4uw	830	28	dependent	dependent	JJ
cord-001835-0s7ok4uw	830	29	regulation	regulation	NN
cord-001835-0s7ok4uw	830	30	of	of	IN
cord-001835-0s7ok4uw	830	31	cell	cell	NN
cord-001835-0s7ok4uw	830	32	growth	growth	NN
cord-001835-0s7ok4uw	830	33	,	,	,
cord-001835-0s7ok4uw	830	34	differentiation	differentiation	NN
cord-001835-0s7ok4uw	830	35	and	and	CC
cord-001835-0s7ok4uw	830	36	transformation	transformation	NN
cord-001835-0s7ok4uw	830	37	.	.	.
cord-001835-0s7ok4uw	831	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	831	2	counteracts	counteract	VBZ
cord-001835-0s7ok4uw	831	3	protein	protein	NN
cord-001835-0s7ok4uw	831	4	kinases	kinase	NNS
cord-001835-0s7ok4uw	831	5	by	by	IN
cord-001835-0s7ok4uw	831	6	dephosphorylating	dephosphorylate	VBG
cord-001835-0s7ok4uw	831	7	a	a	DT
cord-001835-0s7ok4uw	831	8	number	number	NN
cord-001835-0s7ok4uw	831	9	of	of	IN
cord-001835-0s7ok4uw	831	10	their	-PRON-	PRP$
cord-001835-0s7ok4uw	831	11	substrates	substrate	NNS
cord-001835-0s7ok4uw	831	12	as	as	RB
cord-001835-0s7ok4uw	831	13	well	well	RB
cord-001835-0s7ok4uw	831	14	as	as	IN
cord-001835-0s7ok4uw	831	15	the	the	DT
cord-001835-0s7ok4uw	831	16	kinases	kinase	NNS
cord-001835-0s7ok4uw	831	17	themselves	-PRON-	PRP
cord-001835-0s7ok4uw	831	18	,	,	,
cord-001835-0s7ok4uw	831	19	thus	thus	RB
cord-001835-0s7ok4uw	831	20	potentially	potentially	RB
cord-001835-0s7ok4uw	831	21	controlling	control	VBG
cord-001835-0s7ok4uw	831	22	the	the	DT
cord-001835-0s7ok4uw	831	23	specificity	specificity	NN
cord-001835-0s7ok4uw	831	24	of	of	IN
cord-001835-0s7ok4uw	831	25	signals	signal	NNS
cord-001835-0s7ok4uw	831	26	.	.	.
cord-001835-0s7ok4uw	832	1	For	for	IN
cord-001835-0s7ok4uw	832	2	example	example	NN
cord-001835-0s7ok4uw	832	3	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	832	4	,	,	,
cord-001835-0s7ok4uw	832	5	VEGFR	VEGFR	NNP
cord-001835-0s7ok4uw	832	6	2	2	CD
cord-001835-0s7ok4uw	832	7	,	,	,
cord-001835-0s7ok4uw	832	8	Met	Met	NNP
cord-001835-0s7ok4uw	832	9	,	,	,
cord-001835-0s7ok4uw	832	10	PDGF	PDGF	NNP
cord-001835-0s7ok4uw	832	11	b	b	NN
cord-001835-0s7ok4uw	832	12	receptor	receptor	NN
cord-001835-0s7ok4uw	832	13	have	have	VBP
cord-001835-0s7ok4uw	832	14	been	be	VBN
cord-001835-0s7ok4uw	832	15	shown	show	VBN
cord-001835-0s7ok4uw	832	16	to	to	TO
cord-001835-0s7ok4uw	832	17	be	be	VB
cord-001835-0s7ok4uw	832	18	dephosphorylated	dephosphorylate	VBN
cord-001835-0s7ok4uw	832	19	by	by	IN
cord-001835-0s7ok4uw	832	20	this	this	DT
cord-001835-0s7ok4uw	832	21	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	832	22	.	.	.
cord-001835-0s7ok4uw	833	1	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	833	2	has	have	VBZ
cord-001835-0s7ok4uw	833	3	been	be	VBN
cord-001835-0s7ok4uw	833	4	shown	show	VBN
cord-001835-0s7ok4uw	833	5	to	to	TO
cord-001835-0s7ok4uw	833	6	act	act	VB
cord-001835-0s7ok4uw	833	7	as	as	IN
cord-001835-0s7ok4uw	833	8	a	a	DT
cord-001835-0s7ok4uw	833	9	tumor	tumor	NN
cord-001835-0s7ok4uw	833	10	suppressor	suppressor	NN
cord-001835-0s7ok4uw	833	11	and	and	CC
cord-001835-0s7ok4uw	833	12	it	-PRON-	PRP
cord-001835-0s7ok4uw	833	13	has	have	VBZ
cord-001835-0s7ok4uw	833	14	been	be	VBN
cord-001835-0s7ok4uw	833	15	proposed	propose	VBN
cord-001835-0s7ok4uw	833	16	as	as	IN
cord-001835-0s7ok4uw	833	17	a	a	DT
cord-001835-0s7ok4uw	833	18	molecular	molecular	JJ
cord-001835-0s7ok4uw	833	19	target	target	NN
cord-001835-0s7ok4uw	833	20	in	in	IN
cord-001835-0s7ok4uw	833	21	antiangiogenesis	antiangiogenesis	NN
cord-001835-0s7ok4uw	833	22	therapy	therapy	NN
cord-001835-0s7ok4uw	833	23	.	.	.
cord-001835-0s7ok4uw	834	1	As	as	IN
cord-001835-0s7ok4uw	834	2	a	a	DT
cord-001835-0s7ok4uw	834	3	result	result	NN
cord-001835-0s7ok4uw	834	4	,	,	,
cord-001835-0s7ok4uw	834	5	both	both	DT
cord-001835-0s7ok4uw	834	6	enhancers	enhancer	NNS
cord-001835-0s7ok4uw	834	7	and	and	CC
cord-001835-0s7ok4uw	834	8	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	834	9	of	of	IN
cord-001835-0s7ok4uw	834	10	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	834	11	activity	activity	NN
cord-001835-0s7ok4uw	834	12	have	have	VBP
cord-001835-0s7ok4uw	834	13	the	the	DT
cord-001835-0s7ok4uw	834	14	potential	potential	NN
cord-001835-0s7ok4uw	834	15	of	of	IN
cord-001835-0s7ok4uw	834	16	elucidating	elucidate	VBG
cord-001835-0s7ok4uw	834	17	pathways	pathway	NNS
cord-001835-0s7ok4uw	834	18	responsible	responsible	JJ
cord-001835-0s7ok4uw	834	19	for	for	IN
cord-001835-0s7ok4uw	834	20	abnormal	abnormal	JJ
cord-001835-0s7ok4uw	834	21	cell	cell	NN
cord-001835-0s7ok4uw	834	22	behavior	behavior	NN
cord-001835-0s7ok4uw	834	23	.	.	.
cord-001835-0s7ok4uw	835	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	835	2	generated	generate	VBD
cord-001835-0s7ok4uw	835	3	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	835	4	antibodies	antibody	NNS
cord-001835-0s7ok4uw	835	5	against	against	IN
cord-001835-0s7ok4uw	835	6	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	835	7	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	835	8	domain	domain	NN
cord-001835-0s7ok4uw	835	9	of	of	IN
cord-001835-0s7ok4uw	835	10	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	835	11	that	that	WDT
cord-001835-0s7ok4uw	835	12	act	act	NN
cord-001835-0s7ok4uw	835	13	as	as	IN
cord-001835-0s7ok4uw	835	14	modulators	modulator	NNS
cord-001835-0s7ok4uw	835	15	of	of	IN
cord-001835-0s7ok4uw	835	16	the	the	DT
cord-001835-0s7ok4uw	835	17	enzyme	enzyme	NN
cord-001835-0s7ok4uw	835	18	's	's	POS
cord-001835-0s7ok4uw	835	19	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	835	20	activity	activity	NN
cord-001835-0s7ok4uw	835	21	.	.	.
cord-001835-0s7ok4uw	836	1	By	by	IN
cord-001835-0s7ok4uw	836	2	applying	apply	VBG
cord-001835-0s7ok4uw	836	3	a	a	DT
cord-001835-0s7ok4uw	836	4	combination	combination	NN
cord-001835-0s7ok4uw	836	5	of	of	IN
cord-001835-0s7ok4uw	836	6	selection	selection	NN
cord-001835-0s7ok4uw	836	7	pressures	pressure	VBZ
cord-001835-0s7ok4uw	836	8	an	an	DT
cord-001835-0s7ok4uw	836	9	array	array	NN
cord-001835-0s7ok4uw	836	10	of	of	IN
cord-001835-0s7ok4uw	836	11	antibodies	antibody	NNS
cord-001835-0s7ok4uw	836	12	has	have	VBZ
cord-001835-0s7ok4uw	836	13	been	be	VBN
cord-001835-0s7ok4uw	836	14	raised	raise	VBN
cord-001835-0s7ok4uw	836	15	from	from	IN
cord-001835-0s7ok4uw	836	16	phage	phage	NN
cord-001835-0s7ok4uw	836	17	display	display	NN
cord-001835-0s7ok4uw	836	18	libraries	library	NNS
cord-001835-0s7ok4uw	836	19	of	of	IN
cord-001835-0s7ok4uw	836	20	Fab	fab	JJ
cord-001835-0s7ok4uw	836	21	fragments	fragment	NNS
cord-001835-0s7ok4uw	836	22	which	which	WDT
cord-001835-0s7ok4uw	836	23	are	be	VBP
cord-001835-0s7ok4uw	836	24	capable	capable	JJ
cord-001835-0s7ok4uw	836	25	of	of	IN
cord-001835-0s7ok4uw	836	26	either	either	DT
cord-001835-0s7ok4uw	836	27	enhancing	enhance	VBG
cord-001835-0s7ok4uw	836	28	or	or	CC
cord-001835-0s7ok4uw	836	29	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	836	30	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	836	31	activity	activity	NN
cord-001835-0s7ok4uw	836	32	.	.	.
cord-001835-0s7ok4uw	837	1	In	in	IN
cord-001835-0s7ok4uw	837	2	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	837	3	assays	assay	NNS
cord-001835-0s7ok4uw	837	4	with	with	IN
cord-001835-0s7ok4uw	837	5	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	837	6	domain	domain	NN
cord-001835-0s7ok4uw	837	7	of	of	IN
cord-001835-0s7ok4uw	837	8	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	838	1	the	the	DT
cord-001835-0s7ok4uw	838	2	antibodies	antibody	NNS
cord-001835-0s7ok4uw	838	3	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	838	4	non	non	JJ
cord-001835-0s7ok4uw	838	5	-	-	JJ
cord-001835-0s7ok4uw	838	6	competitive	competitive	JJ
cord-001835-0s7ok4uw	838	7	or	or	CC
cord-001835-0s7ok4uw	838	8	mixed	mixed	JJ
cord-001835-0s7ok4uw	838	9	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	838	10	.	.	.
cord-001835-0s7ok4uw	839	1	The	the	DT
cord-001835-0s7ok4uw	839	2	crystal	crystal	JJ
cord-001835-0s7ok4uw	839	3	structure	structure	NN
cord-001835-0s7ok4uw	839	4	of	of	IN
cord-001835-0s7ok4uw	839	5	DEP-1-inhibitor	dep-1-inhibitor	NN
cord-001835-0s7ok4uw	839	6	complex	complex	NN
cord-001835-0s7ok4uw	839	7	shows	show	VBZ
cord-001835-0s7ok4uw	839	8	that	that	IN
cord-001835-0s7ok4uw	839	9	this	this	DT
cord-001835-0s7ok4uw	839	10	antibody	antibody	NN
cord-001835-0s7ok4uw	839	11	binds	bind	VBZ
cord-001835-0s7ok4uw	839	12	to	to	IN
cord-001835-0s7ok4uw	839	13	the	the	DT
cord-001835-0s7ok4uw	839	14	part	part	NN
cord-001835-0s7ok4uw	839	15	of	of	IN
cord-001835-0s7ok4uw	839	16	the	the	DT
cord-001835-0s7ok4uw	839	17	protein	protein	NN
cord-001835-0s7ok4uw	839	18	that	that	WDT
cord-001835-0s7ok4uw	839	19	is	be	VBZ
cord-001835-0s7ok4uw	839	20	distant	distant	JJ
cord-001835-0s7ok4uw	839	21	from	from	IN
cord-001835-0s7ok4uw	839	22	the	the	DT
cord-001835-0s7ok4uw	839	23	active	active	JJ
cord-001835-0s7ok4uw	839	24	site	site	NN
cord-001835-0s7ok4uw	839	25	and	and	CC
cord-001835-0s7ok4uw	839	26	acts	act	NNS
cord-001835-0s7ok4uw	839	27	by	by	IN
cord-001835-0s7ok4uw	839	28	locking	lock	VBG
cord-001835-0s7ok4uw	839	29	the	the	DT
cord-001835-0s7ok4uw	839	30	enzyme	enzyme	NN
cord-001835-0s7ok4uw	839	31	in	in	IN
cord-001835-0s7ok4uw	839	32	the	the	DT
cord-001835-0s7ok4uw	839	33	nonnatural	nonnatural	NN
cord-001835-0s7ok4uw	839	34	catalytically	catalytically	RB
cord-001835-0s7ok4uw	839	35	inactive	inactive	JJ
cord-001835-0s7ok4uw	839	36	state	state	NN
cord-001835-0s7ok4uw	839	37	by	by	IN
cord-001835-0s7ok4uw	839	38	hindering	hinder	VBG
cord-001835-0s7ok4uw	839	39	the	the	DT
cord-001835-0s7ok4uw	839	40	closure	closure	NN
cord-001835-0s7ok4uw	839	41	of	of	IN
cord-001835-0s7ok4uw	839	42	the	the	DT
cord-001835-0s7ok4uw	839	43	WPD	WPD	NNP
cord-001835-0s7ok4uw	839	44	loop	loop	NN
cord-001835-0s7ok4uw	839	45	which	which	WDT
cord-001835-0s7ok4uw	839	46	is	be	VBZ
cord-001835-0s7ok4uw	839	47	crucial	crucial	JJ
cord-001835-0s7ok4uw	839	48	for	for	IN
cord-001835-0s7ok4uw	839	49	the	the	DT
cord-001835-0s7ok4uw	839	50	reaction	reaction	NN
cord-001835-0s7ok4uw	839	51	to	to	TO
cord-001835-0s7ok4uw	839	52	occur	occur	VB
cord-001835-0s7ok4uw	839	53	.	.	.
cord-001835-0s7ok4uw	840	1	By	by	IN
cord-001835-0s7ok4uw	840	2	contrast	contrast	NN
cord-001835-0s7ok4uw	840	3	,	,	,
cord-001835-0s7ok4uw	840	4	as	as	IN
cord-001835-0s7ok4uw	840	5	judged	judge	VBN
cord-001835-0s7ok4uw	840	6	from	from	IN
cord-001835-0s7ok4uw	840	7	the	the	DT
cord-001835-0s7ok4uw	840	8	crystal	crystal	JJ
cord-001835-0s7ok4uw	840	9	structure	structure	NN
cord-001835-0s7ok4uw	840	10	of	of	IN
cord-001835-0s7ok4uw	840	11	a	a	DT
cord-001835-0s7ok4uw	840	12	complex	complex	NN
cord-001835-0s7ok4uw	840	13	of	of	IN
cord-001835-0s7ok4uw	840	14	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	840	15	with	with	IN
cord-001835-0s7ok4uw	840	16	the	the	DT
cord-001835-0s7ok4uw	840	17	antibody	antibody	NN
cord-001835-0s7ok4uw	840	18	that	that	WDT
cord-001835-0s7ok4uw	840	19	enhances	enhance	VBZ
cord-001835-0s7ok4uw	840	20	its	-PRON-	PRP$
cord-001835-0s7ok4uw	840	21	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	840	22	activity	activity	NN
cord-001835-0s7ok4uw	840	23	,	,	,
cord-001835-0s7ok4uw	840	24	this	this	DT
cord-001835-0s7ok4uw	840	25	antibody	antibody	NN
cord-001835-0s7ok4uw	840	26	seems	seem	VBZ
cord-001835-0s7ok4uw	840	27	to	to	TO
cord-001835-0s7ok4uw	840	28	act	act	VB
cord-001835-0s7ok4uw	840	29	by	by	IN
cord-001835-0s7ok4uw	840	30	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	840	31	the	the	DT
cord-001835-0s7ok4uw	840	32	naturally	naturally	RB
cord-001835-0s7ok4uw	840	33	found	find	VBN
cord-001835-0s7ok4uw	840	34	active	active	JJ
cord-001835-0s7ok4uw	840	35	state	state	NN
cord-001835-0s7ok4uw	840	36	of	of	IN
cord-001835-0s7ok4uw	840	37	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	840	38	with	with	IN
cord-001835-0s7ok4uw	840	39	WPD	WPD	NNP
cord-001835-0s7ok4uw	840	40	loop	loop	NN
cord-001835-0s7ok4uw	840	41	in	in	IN
cord-001835-0s7ok4uw	840	42	the	the	DT
cord-001835-0s7ok4uw	840	43	closed	closed	JJ
cord-001835-0s7ok4uw	840	44	conformation	conformation	NN
cord-001835-0s7ok4uw	840	45	.	.	.
cord-001835-0s7ok4uw	841	1	The	the	DT
cord-001835-0s7ok4uw	841	2	antibodies	antibody	NNS
cord-001835-0s7ok4uw	841	3	are	be	VBP
cord-001835-0s7ok4uw	841	4	also	also	RB
cord-001835-0s7ok4uw	841	5	able	able	JJ
cord-001835-0s7ok4uw	841	6	to	to	TO
cord-001835-0s7ok4uw	841	7	recognize	recognize	VB
cord-001835-0s7ok4uw	841	8	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	841	9	in	in	IN
cord-001835-0s7ok4uw	841	10	cells	cell	NNS
cord-001835-0s7ok4uw	841	11	,	,	,
cord-001835-0s7ok4uw	841	12	as	as	IN
cord-001835-0s7ok4uw	841	13	they	-PRON-	PRP
cord-001835-0s7ok4uw	841	14	stain	stain	VBP
cord-001835-0s7ok4uw	841	15	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	841	16	in	in	IN
cord-001835-0s7ok4uw	841	17	immunofluorescence	immunofluorescence	NN
cord-001835-0s7ok4uw	841	18	experiments	experiment	NNS
cord-001835-0s7ok4uw	841	19	.	.	.
cord-001835-0s7ok4uw	842	1	To	to	TO
cord-001835-0s7ok4uw	842	2	test	test	VB
cord-001835-0s7ok4uw	842	3	the	the	DT
cord-001835-0s7ok4uw	842	4	applicability	applicability	NN
cord-001835-0s7ok4uw	842	5	of	of	IN
cord-001835-0s7ok4uw	842	6	raised	raise	VBN
cord-001835-0s7ok4uw	842	7	antibodies	antibody	NNS
cord-001835-0s7ok4uw	842	8	in	in	IN
cord-001835-0s7ok4uw	842	9	cells	cell	NNS
cord-001835-0s7ok4uw	842	10	the	the	DT
cord-001835-0s7ok4uw	842	11	activator	activator	NN
cord-001835-0s7ok4uw	842	12	was	be	VBD
cord-001835-0s7ok4uw	842	13	additionally	additionally	RB
cord-001835-0s7ok4uw	842	14	used	use	VBN
cord-001835-0s7ok4uw	842	15	to	to	TO
cord-001835-0s7ok4uw	842	16	pull	pull	VB
cord-001835-0s7ok4uw	842	17	down	down	RP
cord-001835-0s7ok4uw	842	18	full	full	JJ
cord-001835-0s7ok4uw	842	19	-	-	HYPH
cord-001835-0s7ok4uw	842	20	length	length	NN
cord-001835-0s7ok4uw	842	21	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	842	22	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	842	23	after	after	IN
cord-001835-0s7ok4uw	842	24	being	be	VBG
cord-001835-0s7ok4uw	842	25	delivered	deliver	VBN
cord-001835-0s7ok4uw	842	26	to	to	TO
cord-001835-0s7ok4uw	842	27	live	live	VB
cord-001835-0s7ok4uw	842	28	cells	cell	NNS
cord-001835-0s7ok4uw	842	29	.	.	.
cord-001835-0s7ok4uw	843	1	Inhibition	inhibition	NN
cord-001835-0s7ok4uw	843	2	and	and	CC
cord-001835-0s7ok4uw	843	3	enhancement	enhancement	NN
cord-001835-0s7ok4uw	843	4	of	of	IN
cord-001835-0s7ok4uw	843	5	DEP-1	DEP-1	NNP
cord-001835-0s7ok4uw	843	6	activity	activity	NN
cord-001835-0s7ok4uw	843	7	by	by	IN
cord-001835-0s7ok4uw	843	8	locking	lock	VBG
cord-001835-0s7ok4uw	843	9	the	the	DT
cord-001835-0s7ok4uw	843	10	enzyme	enzyme	NN
cord-001835-0s7ok4uw	843	11	in	in	IN
cord-001835-0s7ok4uw	843	12	conformations	conformation	NNS
cord-001835-0s7ok4uw	843	13	which	which	WDT
cord-001835-0s7ok4uw	843	14	are	be	VBP
cord-001835-0s7ok4uw	843	15	either	either	CC
cord-001835-0s7ok4uw	843	16	natural	natural	JJ
cord-001835-0s7ok4uw	843	17	or	or	CC
cord-001835-0s7ok4uw	843	18	imposed	impose	VBN
cord-001835-0s7ok4uw	843	19	by	by	IN
cord-001835-0s7ok4uw	843	20	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	843	21	binding	binding	NN
cord-001835-0s7ok4uw	843	22	of	of	IN
cord-001835-0s7ok4uw	843	23	antibodies	antibody	NNS
cord-001835-0s7ok4uw	843	24	seems	seem	VBZ
cord-001835-0s7ok4uw	843	25	to	to	TO
cord-001835-0s7ok4uw	843	26	be	be	VB
cord-001835-0s7ok4uw	843	27	a	a	DT
cord-001835-0s7ok4uw	843	28	mechanism	mechanism	NN
cord-001835-0s7ok4uw	843	29	that	that	WDT
cord-001835-0s7ok4uw	843	30	can	can	MD
cord-001835-0s7ok4uw	843	31	be	be	VB
cord-001835-0s7ok4uw	843	32	utilized	utilize	VBN
cord-001835-0s7ok4uw	843	33	to	to	TO
cord-001835-0s7ok4uw	843	34	modulate	modulate	VB
cord-001835-0s7ok4uw	843	35	activity	activity	NN
cord-001835-0s7ok4uw	843	36	of	of	IN
cord-001835-0s7ok4uw	843	37	other	other	JJ
cord-001835-0s7ok4uw	843	38	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	843	39	phosphatases	phosphatase	NNS
cord-001835-0s7ok4uw	843	40	.	.	.
cord-001835-0s7ok4uw	844	1	Investigating	investigate	VBG
cord-001835-0s7ok4uw	844	2	Acinetobacter	Acinetobacter	NNP
cord-001835-0s7ok4uw	844	3	baumannii	baumannii	NNP
cord-001835-0s7ok4uw	844	4	pathogenesis	pathogenesis	NN
cord-001835-0s7ok4uw	844	5	:	:	:
cord-001835-0s7ok4uw	844	6	crystal	crystal	NN
cord-001835-0s7ok4uw	844	7	structure	structure	NN
cord-001835-0s7ok4uw	844	8	of	of	IN
cord-001835-0s7ok4uw	844	9	WbjB	WbjB	NNP
cord-001835-0s7ok4uw	844	10	epimerase	epimerase	NN
cord-001835-0s7ok4uw	844	11	from	from	IN
cord-001835-0s7ok4uw	844	12	a	a	DT
cord-001835-0s7ok4uw	844	13	polysaccharide	polysaccharide	NN
cord-001835-0s7ok4uw	844	14	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	844	15	cluster	cluster	NN
cord-001835-0s7ok4uw	844	16	 	 	_SP
cord-001835-0s7ok4uw	844	17	Oxygen	Oxygen	NNP
cord-001835-0s7ok4uw	844	18	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	844	19	is	be	VBZ
cord-001835-0s7ok4uw	844	20	regulated	regulate	VBN
cord-001835-0s7ok4uw	844	21	by	by	IN
cord-001835-0s7ok4uw	844	22	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	844	23	inducible	inducible	JJ
cord-001835-0s7ok4uw	844	24	factor	factor	NN
cord-001835-0s7ok4uw	844	25	,	,	,
cord-001835-0s7ok4uw	844	26	a	a	DT
cord-001835-0s7ok4uw	844	27	transcription	transcription	NN
cord-001835-0s7ok4uw	844	28	factor	factor	NN
cord-001835-0s7ok4uw	844	29	.	.	.
cord-001835-0s7ok4uw	845	1	When	when	WRB
cord-001835-0s7ok4uw	845	2	the	the	DT
cord-001835-0s7ok4uw	845	3	oxygen	oxygen	NN
cord-001835-0s7ok4uw	845	4	level	level	NN
cord-001835-0s7ok4uw	845	5	becomes	become	VBZ
cord-001835-0s7ok4uw	845	6	too	too	RB
cord-001835-0s7ok4uw	845	7	low	low	JJ
cord-001835-0s7ok4uw	845	8	(	(	-LRB-
cord-001835-0s7ok4uw	845	9	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	845	10	)	)	-RRB-
cord-001835-0s7ok4uw	845	11	,	,	,
cord-001835-0s7ok4uw	845	12	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	845	13	-	-	HYPH
cord-001835-0s7ok4uw	845	14	inducible	inducible	JJ
cord-001835-0s7ok4uw	845	15	-	-	HYPH
cord-001835-0s7ok4uw	845	16	factor	factor	NN
cord-001835-0s7ok4uw	845	17	1	1	CD
cord-001835-0s7ok4uw	845	18	(	(	-LRB-
cord-001835-0s7ok4uw	845	19	HIF-1a	HIF-1a	NNP
cord-001835-0s7ok4uw	845	20	)	)	-RRB-
cord-001835-0s7ok4uw	845	21	activates	activate	VBZ
cord-001835-0s7ok4uw	845	22	the	the	DT
cord-001835-0s7ok4uw	845	23	expression	expression	NN
cord-001835-0s7ok4uw	845	24	of	of	IN
cord-001835-0s7ok4uw	845	25	over	over	IN
cord-001835-0s7ok4uw	845	26	a	a	DT
cord-001835-0s7ok4uw	845	27	hundred	hundred	CD
cord-001835-0s7ok4uw	845	28	genes	gene	NNS
cord-001835-0s7ok4uw	845	29	,	,	,
cord-001835-0s7ok4uw	845	30	associated	associate	VBN
cord-001835-0s7ok4uw	845	31	with	with	IN
cord-001835-0s7ok4uw	845	32	angiogenesis	angiogenesis	NN
cord-001835-0s7ok4uw	845	33	,	,	,
cord-001835-0s7ok4uw	845	34	erythropoiesis	erythropoiesis	NN
cord-001835-0s7ok4uw	845	35	,	,	,
cord-001835-0s7ok4uw	845	36	VEGF	VEGF	NNP
cord-001835-0s7ok4uw	845	37	(	(	-LRB-
cord-001835-0s7ok4uw	845	38	vascular	vascular	JJ
cord-001835-0s7ok4uw	845	39	endothelial	endothelial	JJ
cord-001835-0s7ok4uw	845	40	growth	growth	NN
cord-001835-0s7ok4uw	845	41	factor	factor	NN
cord-001835-0s7ok4uw	845	42	)	)	-RRB-
cord-001835-0s7ok4uw	845	43	,	,	,
cord-001835-0s7ok4uw	845	44	cell	cell	NN
cord-001835-0s7ok4uw	845	45	migration	migration	NN
cord-001835-0s7ok4uw	845	46	,	,	,
cord-001835-0s7ok4uw	845	47	and	and	CC
cord-001835-0s7ok4uw	845	48	energy	energy	NN
cord-001835-0s7ok4uw	845	49	metabolism	metabolism	NN
cord-001835-0s7ok4uw	845	50	etc	etc	FW
cord-001835-0s7ok4uw	845	51	.	.	.
cord-001835-0s7ok4uw	846	1	HIF-1a	HIF-1a	NNP
cord-001835-0s7ok4uw	846	2	cellular	cellular	JJ
cord-001835-0s7ok4uw	846	3	level	level	NN
cord-001835-0s7ok4uw	846	4	is	be	VBZ
cord-001835-0s7ok4uw	846	5	highly	highly	RB
cord-001835-0s7ok4uw	846	6	dependent	dependent	JJ
cord-001835-0s7ok4uw	846	7	on	on	IN
cord-001835-0s7ok4uw	846	8	oxygen	oxygen	NN
cord-001835-0s7ok4uw	846	9	concentration	concentration	NN
cord-001835-0s7ok4uw	846	10	and	and	CC
cord-001835-0s7ok4uw	846	11	regulated	regulate	VBN
cord-001835-0s7ok4uw	846	12	by	by	IN
cord-001835-0s7ok4uw	846	13	oxygen	oxygen	NN
cord-001835-0s7ok4uw	846	14	sensor	sensor	NN
cord-001835-0s7ok4uw	846	15	enzyme	enzyme	NN
cord-001835-0s7ok4uw	846	16	,	,	,
cord-001835-0s7ok4uw	846	17	HIF	HIF	NNP
cord-001835-0s7ok4uw	846	18	prolyl	prolyl	JJ
cord-001835-0s7ok4uw	846	19	hydroxylase	hydroxylase	NN
cord-001835-0s7ok4uw	846	20	(	(	-LRB-
cord-001835-0s7ok4uw	847	1	PHD2	PHD2	NNP
cord-001835-0s7ok4uw	847	2	Plant	Plant	NNP
cord-001835-0s7ok4uw	847	3	sulphite	sulphite	NN
cord-001835-0s7ok4uw	847	4	reductase	reductase	NN
cord-001835-0s7ok4uw	847	5	(	(	-LRB-
cord-001835-0s7ok4uw	847	6	SiR	SiR	NNP
cord-001835-0s7ok4uw	847	7	)	)	-RRB-
cord-001835-0s7ok4uw	847	8	forms	form	VBZ
cord-001835-0s7ok4uw	847	9	an	an	DT
cord-001835-0s7ok4uw	847	10	electron	electron	NN
cord-001835-0s7ok4uw	847	11	transfer	transfer	NN
cord-001835-0s7ok4uw	847	12	complex	complex	NN
cord-001835-0s7ok4uw	847	13	with	with	IN
cord-001835-0s7ok4uw	847	14	ferredoxin	ferredoxin	NN
cord-001835-0s7ok4uw	847	15	(	(	-LRB-
cord-001835-0s7ok4uw	847	16	Fd	Fd	NNP
cord-001835-0s7ok4uw	847	17	)	)	-RRB-
cord-001835-0s7ok4uw	847	18	for	for	IN
cord-001835-0s7ok4uw	847	19	the	the	DT
cord-001835-0s7ok4uw	847	20	reductive	reductive	JJ
cord-001835-0s7ok4uw	847	21	conversion	conversion	NN
cord-001835-0s7ok4uw	847	22	of	of	IN
cord-001835-0s7ok4uw	847	23	sulphite	sulphite	NN
cord-001835-0s7ok4uw	847	24	to	to	IN
cord-001835-0s7ok4uw	847	25	sulphide	sulphide	NN
cord-001835-0s7ok4uw	847	26	.	.	.
cord-001835-0s7ok4uw	848	1	Although	although	IN
cord-001835-0s7ok4uw	848	2	previous	previous	JJ
cord-001835-0s7ok4uw	848	3	studies	study	NNS
cord-001835-0s7ok4uw	848	4	have	have	VBP
cord-001835-0s7ok4uw	848	5	highlighted	highlight	VBN
cord-001835-0s7ok4uw	848	6	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	848	7	interactions	interaction	NNS
cord-001835-0s7ok4uw	848	8	between	between	IN
cord-001835-0s7ok4uw	848	9	oppositely	oppositely	RB
cord-001835-0s7ok4uw	848	10	-	-	HYPH
cord-001835-0s7ok4uw	848	11	charged	charge	VBN
cord-001835-0s7ok4uw	848	12	residues	residue	NNS
cord-001835-0s7ok4uw	848	13	of	of	IN
cord-001835-0s7ok4uw	848	14	the	the	DT
cord-001835-0s7ok4uw	848	15	two	two	CD
cord-001835-0s7ok4uw	848	16	proteins	protein	NNS
cord-001835-0s7ok4uw	848	17	,	,	,
cord-001835-0s7ok4uw	848	18	detailed	detailed	JJ
cord-001835-0s7ok4uw	848	19	thermoenergetics	thermoenergetic	NNS
cord-001835-0s7ok4uw	848	20	of	of	IN
cord-001835-0s7ok4uw	848	21	the	the	DT
cord-001835-0s7ok4uw	848	22	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	848	23	interaction	interaction	NN
cord-001835-0s7ok4uw	848	24	for	for	IN
cord-001835-0s7ok4uw	848	25	the	the	DT
cord-001835-0s7ok4uw	848	26	complexation	complexation	NN
cord-001835-0s7ok4uw	848	27	remains	remain	VBZ
cord-001835-0s7ok4uw	848	28	unknown	unknown	JJ
cord-001835-0s7ok4uw	848	29	.	.	.
cord-001835-0s7ok4uw	849	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	849	2	herein	herein	RB
cord-001835-0s7ok4uw	849	3	carried	carry	VBD
cord-001835-0s7ok4uw	849	4	out	out	RP
cord-001835-0s7ok4uw	849	5	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	849	6	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	849	7	of	of	IN
cord-001835-0s7ok4uw	849	8	Fd	Fd	NNP
cord-001835-0s7ok4uw	849	9	:	:	:
cord-001835-0s7ok4uw	849	10	SiR	SiR	NNP
cord-001835-0s7ok4uw	849	11	complex	complex	JJ
cord-001835-0s7ok4uw	849	12	formation	formation	NN
cord-001835-0s7ok4uw	849	13	at	at	IN
cord-001835-0s7ok4uw	849	14	various	various	JJ
cord-001835-0s7ok4uw	849	15	NaCl	nacl	NN
cord-001835-0s7ok4uw	849	16	concentrations	concentration	NNS
cord-001835-0s7ok4uw	849	17	.	.	.
cord-001835-0s7ok4uw	850	1	Driving	drive	VBG
cord-001835-0s7ok4uw	850	2	force	force	NN
cord-001835-0s7ok4uw	850	3	plot	plot	NN
cord-001835-0s7ok4uw	850	4	constructed	construct	VBN
cord-001835-0s7ok4uw	850	5	from	from	IN
cord-001835-0s7ok4uw	850	6	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	850	7	showed	show	VBD
cord-001835-0s7ok4uw	850	8	that	that	IN
cord-001835-0s7ok4uw	850	9	the	the	DT
cord-001835-0s7ok4uw	850	10	complex	complex	NN
cord-001835-0s7ok4uw	850	11	was	be	VBD
cord-001835-0s7ok4uw	850	12	thermodynamically	thermodynamically	RB
cord-001835-0s7ok4uw	850	13	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	850	14	by	by	IN
cord-001835-0s7ok4uw	850	15	both	both	CC
cord-001835-0s7ok4uw	850	16	enthalpy	enthalpy	NN
cord-001835-0s7ok4uw	850	17	and	and	CC
cord-001835-0s7ok4uw	850	18	entropy	entropy	NN
cord-001835-0s7ok4uw	850	19	through	through	IN
cord-001835-0s7ok4uw	850	20	favourable	favourable	JJ
cord-001835-0s7ok4uw	850	21	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	850	22	and	and	CC
cord-001835-0s7ok4uw	850	23	non	non	JJ
cord-001835-0s7ok4uw	850	24	-	-	JJ
cord-001835-0s7ok4uw	850	25	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	850	26	interactions	interaction	NNS
cord-001835-0s7ok4uw	850	27	.	.	.
cord-001835-0s7ok4uw	851	1	Increasing	increase	VBG
cord-001835-0s7ok4uw	851	2	NaCl	nacl	NN
cord-001835-0s7ok4uw	851	3	concentrations	concentration	NNS
cord-001835-0s7ok4uw	851	4	weakened	weaken	VBD
cord-001835-0s7ok4uw	851	5	interprotein	interprotein	NNP
cord-001835-0s7ok4uw	851	6	affinity	affinity	NN
cord-001835-0s7ok4uw	851	7	and	and	CC
cord-001835-0s7ok4uw	851	8	contribution	contribution	NN
cord-001835-0s7ok4uw	851	9	of	of	IN
cord-001835-0s7ok4uw	851	10	the	the	DT
cord-001835-0s7ok4uw	851	11	negative	negative	JJ
cord-001835-0s7ok4uw	851	12	enthalpy	enthalpy	NN
cord-001835-0s7ok4uw	851	13	changes	change	NNS
cord-001835-0s7ok4uw	851	14	became	become	VBD
cord-001835-0s7ok4uw	851	15	decreased	decrease	VBN
cord-001835-0s7ok4uw	851	16	,	,	,
cord-001835-0s7ok4uw	851	17	while	while	IN
cord-001835-0s7ok4uw	851	18	no	no	DT
cord-001835-0s7ok4uw	851	19	such	such	JJ
cord-001835-0s7ok4uw	851	20	significant	significant	JJ
cord-001835-0s7ok4uw	851	21	decrease	decrease	NN
cord-001835-0s7ok4uw	851	22	was	be	VBD
cord-001835-0s7ok4uw	851	23	found	find	VBN
cord-001835-0s7ok4uw	851	24	in	in	IN
cord-001835-0s7ok4uw	851	25	the	the	DT
cord-001835-0s7ok4uw	851	26	contribution	contribution	NN
cord-001835-0s7ok4uw	851	27	of	of	IN
cord-001835-0s7ok4uw	851	28	positive	positive	JJ
cord-001835-0s7ok4uw	851	29	entropy	entropy	NN
cord-001835-0s7ok4uw	851	30	changes	change	NNS
cord-001835-0s7ok4uw	851	31	.	.	.
cord-001835-0s7ok4uw	852	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	852	2	,	,	,
cord-001835-0s7ok4uw	852	3	a	a	DT
cord-001835-0s7ok4uw	852	4	negative	negative	JJ
cord-001835-0s7ok4uw	852	5	heat	heat	NN
cord-001835-0s7ok4uw	852	6	capacity	capacity	NN
cord-001835-0s7ok4uw	852	7	change	change	NN
cord-001835-0s7ok4uw	852	8	obtained	obtain	VBN
cord-001835-0s7ok4uw	852	9	from	from	IN
cord-001835-0s7ok4uw	852	10	the	the	DT
cord-001835-0s7ok4uw	852	11	enthalpy	enthalpy	NN
cord-001835-0s7ok4uw	852	12	changes	change	NNS
cord-001835-0s7ok4uw	852	13	at	at	IN
cord-001835-0s7ok4uw	852	14	distinct	distinct	JJ
cord-001835-0s7ok4uw	852	15	temperature	temperature	NN
cord-001835-0s7ok4uw	852	16	indicated	indicate	VBD
cord-001835-0s7ok4uw	852	17	a	a	DT
cord-001835-0s7ok4uw	852	18	contribution	contribution	NN
cord-001835-0s7ok4uw	852	19	of	of	IN
cord-001835-0s7ok4uw	852	20	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	852	21	interactions	interaction	NNS
cord-001835-0s7ok4uw	852	22	.	.	.
cord-001835-0s7ok4uw	853	1	These	these	DT
cord-001835-0s7ok4uw	853	2	findings	finding	NNS
cord-001835-0s7ok4uw	853	3	suggested	suggest	VBD
cord-001835-0s7ok4uw	853	4	that	that	IN
cord-001835-0s7ok4uw	853	5	both	both	CC
cord-001835-0s7ok4uw	853	6	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	853	7	and	and	CC
cord-001835-0s7ok4uw	853	8	nonelectrostatic	nonelectrostatic	JJ
cord-001835-0s7ok4uw	853	9	interprotein	interprotein	NNP
cord-001835-0s7ok4uw	853	10	interactions	interaction	NNS
cord-001835-0s7ok4uw	853	11	were	be	VBD
cord-001835-0s7ok4uw	853	12	energetically	energetically	RB
cord-001835-0s7ok4uw	853	13	important	important	JJ
cord-001835-0s7ok4uw	853	14	for	for	IN
cord-001835-0s7ok4uw	853	15	the	the	DT
cord-001835-0s7ok4uw	853	16	complex	complex	JJ
cord-001835-0s7ok4uw	853	17	formation	formation	NN
cord-001835-0s7ok4uw	853	18	.	.	.
cord-001835-0s7ok4uw	854	1	Fddependent	Fddependent	NNP
cord-001835-0s7ok4uw	854	2	SiR	sir	NN
cord-001835-0s7ok4uw	854	3	activity	activity	NN
cord-001835-0s7ok4uw	854	4	assay	assay	NN
cord-001835-0s7ok4uw	854	5	revealed	reveal	VBD
cord-001835-0s7ok4uw	854	6	a	a	DT
cord-001835-0s7ok4uw	854	7	bell	bell	NN
cord-001835-0s7ok4uw	854	8	shaped	shape	VBN
cord-001835-0s7ok4uw	854	9	activity	activity	NN
cord-001835-0s7ok4uw	854	10	curve	curve	NN
cord-001835-0s7ok4uw	854	11	with	with	IN
cord-001835-0s7ok4uw	854	12	a	a	DT
cord-001835-0s7ok4uw	854	13	maximum	maximum	NN
cord-001835-0s7ok4uw	854	14	under	under	IN
cord-001835-0s7ok4uw	854	15	a	a	DT
cord-001835-0s7ok4uw	854	16	certain	certain	JJ
cord-001835-0s7ok4uw	854	17	NaCl	nacl	NN
cord-001835-0s7ok4uw	854	18	concentration	concentration	NN
cord-001835-0s7ok4uw	854	19	,	,	,
cord-001835-0s7ok4uw	854	20	while	while	IN
cord-001835-0s7ok4uw	854	21	the	the	DT
cord-001835-0s7ok4uw	854	22	methyl	methyl	NN
cord-001835-0s7ok4uw	854	23	viologen	viologen	NN
cord-001835-0s7ok4uw	854	24	-	-	HYPH
cord-001835-0s7ok4uw	854	25	dependent	dependent	JJ
cord-001835-0s7ok4uw	854	26	assay	assay	NN
cord-001835-0s7ok4uw	854	27	of	of	IN
cord-001835-0s7ok4uw	854	28	SiR	SiR	NNP
cord-001835-0s7ok4uw	854	29	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	854	30	a	a	DT
cord-001835-0s7ok4uw	854	31	profile	profile	NN
cord-001835-0s7ok4uw	854	32	of	of	IN
cord-001835-0s7ok4uw	854	33	saturating	saturate	VBG
cord-001835-0s7ok4uw	854	34	curve	curve	NN
cord-001835-0s7ok4uw	854	35	,	,	,
cord-001835-0s7ok4uw	854	36	suggesting	suggest	VBG
cord-001835-0s7ok4uw	854	37	that	that	IN
cord-001835-0s7ok4uw	854	38	an	an	DT
cord-001835-0s7ok4uw	854	39	optimized	optimize	VBN
cord-001835-0s7ok4uw	854	40	interprotein	interprotein	NN
cord-001835-0s7ok4uw	854	41	interaction	interaction	NN
cord-001835-0s7ok4uw	854	42	is	be	VBZ
cord-001835-0s7ok4uw	854	43	a	a	DT
cord-001835-0s7ok4uw	854	44	crucial	crucial	JJ
cord-001835-0s7ok4uw	854	45	factor	factor	NN
cord-001835-0s7ok4uw	854	46	in	in	IN
cord-001835-0s7ok4uw	854	47	control	control	NN
cord-001835-0s7ok4uw	854	48	of	of	IN
cord-001835-0s7ok4uw	854	49	Fd	fd	NN
cord-001835-0s7ok4uw	854	50	-	-	HYPH
cord-001835-0s7ok4uw	854	51	dependent	dependent	JJ
cord-001835-0s7ok4uw	854	52	-	-	HYPH
cord-001835-0s7ok4uw	854	53	SiR	sir	NN
cord-001835-0s7ok4uw	854	54	activity	activity	NN
cord-001835-0s7ok4uw	854	55	.	.	.
cord-001835-0s7ok4uw	855	1	A	a	DT
cord-001835-0s7ok4uw	855	2	residue	residue	NN
cord-001835-0s7ok4uw	855	3	-	-	HYPH
cord-001835-0s7ok4uw	855	4	based	base	VBN
cord-001835-0s7ok4uw	855	5	NMR	NMR	NNP
cord-001835-0s7ok4uw	855	6	measurement	measurement	NN
cord-001835-0s7ok4uw	855	7	of	of	IN
cord-001835-0s7ok4uw	855	8	15N	15N	NNP
cord-001835-0s7ok4uw	855	9	-	-	HYPH
cord-001835-0s7ok4uw	855	10	labeled	label	VBN
cord-001835-0s7ok4uw	855	11	Fd	Fd	NNP
cord-001835-0s7ok4uw	855	12	upon	upon	IN
cord-001835-0s7ok4uw	855	13	complex	complex	JJ
cord-001835-0s7ok4uw	855	14	formation	formation	NN
cord-001835-0s7ok4uw	855	15	with	with	IN
cord-001835-0s7ok4uw	855	16	SiR	SiR	NNP
cord-001835-0s7ok4uw	855	17	revealed	reveal	VBD
cord-001835-0s7ok4uw	855	18	that	that	IN
cord-001835-0s7ok4uw	855	19	charged	charge	VBN
cord-001835-0s7ok4uw	855	20	and	and	CC
cord-001835-0s7ok4uw	855	21	non	non	JJ
cord-001835-0s7ok4uw	855	22	-	-	JJ
cord-001835-0s7ok4uw	855	23	charged	charge	VBN
cord-001835-0s7ok4uw	855	24	residues	residue	NNS
cord-001835-0s7ok4uw	855	25	were	be	VBD
cord-001835-0s7ok4uw	855	26	differentially	differentially	RB
cord-001835-0s7ok4uw	855	27	contributed	contribute	VBN
cord-001835-0s7ok4uw	855	28	in	in	IN
cord-001835-0s7ok4uw	855	29	the	the	DT
cord-001835-0s7ok4uw	855	30	complex	complex	JJ
cord-001835-0s7ok4uw	855	31	formation	formation	NN
cord-001835-0s7ok4uw	855	32	depending	depend	VBG
cord-001835-0s7ok4uw	855	33	on	on	IN
cord-001835-0s7ok4uw	855	34	NaCl	nacl	NN
cord-001835-0s7ok4uw	855	35	concentrations	concentration	NNS
cord-001835-0s7ok4uw	855	36	.	.	.
cord-001835-0s7ok4uw	856	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	856	2	proposed	propose	VBD
cord-001835-0s7ok4uw	856	3	that	that	IN
cord-001835-0s7ok4uw	856	4	non	non	JJ
cord-001835-0s7ok4uw	856	5	-	-	JJ
cord-001835-0s7ok4uw	856	6	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	856	7	forces	force	NNS
cord-001835-0s7ok4uw	856	8	were	be	VBD
cord-001835-0s7ok4uw	856	9	also	also	RB
cord-001835-0s7ok4uw	856	10	critical	critical	JJ
cord-001835-0s7ok4uw	856	11	for	for	IN
cord-001835-0s7ok4uw	856	12	forming	form	VBG
cord-001835-0s7ok4uw	856	13	the	the	DT
cord-001835-0s7ok4uw	856	14	Fd	Fd	NNP
cord-001835-0s7ok4uw	856	15	:	:	:
cord-001835-0s7ok4uw	856	16	SiR	SiR	NNP
cord-001835-0s7ok4uw	856	17	complex	complex	NNP
cord-001835-0s7ok4uw	856	18	,	,	,
cord-001835-0s7ok4uw	856	19	and	and	CC
cord-001835-0s7ok4uw	856	20	an	an	DT
cord-001835-0s7ok4uw	856	21	optimized	optimize	VBN
cord-001835-0s7ok4uw	856	22	complex	complex	JJ
cord-001835-0s7ok4uw	856	23	conformation	conformation	NN
cord-001835-0s7ok4uw	856	24	for	for	IN
cord-001835-0s7ok4uw	856	25	maximum	maximum	JJ
cord-001835-0s7ok4uw	856	26	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	856	27	activity	activity	NN
cord-001835-0s7ok4uw	856	28	was	be	VBD
cord-001835-0s7ok4uw	856	29	achievable	achievable	JJ
cord-001835-0s7ok4uw	856	30	by	by	IN
cord-001835-0s7ok4uw	856	31	a	a	DT
cord-001835-0s7ok4uw	856	32	delicate	delicate	JJ
cord-001835-0s7ok4uw	856	33	balance	balance	NN
cord-001835-0s7ok4uw	856	34	among	among	IN
cord-001835-0s7ok4uw	856	35	non	non	JJ
cord-001835-0s7ok4uw	856	36	-	-	JJ
cord-001835-0s7ok4uw	856	37	covalent	covalent	JJ
cord-001835-0s7ok4uw	856	38	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	856	39	forces	force	NNS
cord-001835-0s7ok4uw	856	40	.	.	.
cord-001835-0s7ok4uw	857	1	These	these	DT
cord-001835-0s7ok4uw	857	2	results	result	NNS
cord-001835-0s7ok4uw	857	3	may	may	MD
cord-001835-0s7ok4uw	857	4	be	be	VB
cord-001835-0s7ok4uw	857	5	extended	extend	VBN
cord-001835-0s7ok4uw	857	6	for	for	IN
cord-001835-0s7ok4uw	857	7	understanding	understanding	NN
cord-001835-0s7ok4uw	857	8	of	of	IN
cord-001835-0s7ok4uw	857	9	complexation	complexation	NN
cord-001835-0s7ok4uw	857	10	between	between	IN
cord-001835-0s7ok4uw	857	11	redox	redox	NN
cord-001835-0s7ok4uw	857	12	proteins	protein	NNS
cord-001835-0s7ok4uw	857	13	containing	contain	VBG
cord-001835-0s7ok4uw	857	14	biased	biased	JJ
cord-001835-0s7ok4uw	857	15	charge	charge	NN
cord-001835-0s7ok4uw	857	16	clusters	cluster	NNS
cord-001835-0s7ok4uw	857	17	.	.	.
cord-001835-0s7ok4uw	858	1	Ornithine	ornithine	JJ
cord-001835-0s7ok4uw	858	2	transcarbamylase	transcarbamylase	NN
cord-001835-0s7ok4uw	858	3	has	have	VBZ
cord-001835-0s7ok4uw	858	4	a	a	DT
cord-001835-0s7ok4uw	858	5	spatially	spatially	RB
cord-001835-0s7ok4uw	858	6	extended	extend	VBN
cord-001835-0s7ok4uw	858	7	active	active	JJ
cord-001835-0s7ok4uw	858	8	site	site	NN
cord-001835-0s7ok4uw	858	9	as	as	IN
cord-001835-0s7ok4uw	858	10	computationally	computationally	RB
cord-001835-0s7ok4uw	858	11	predicted	predict	VBN
cord-001835-0s7ok4uw	858	12	Lisa	Lisa	NNP
cord-001835-0s7ok4uw	858	13	Ngu	Ngu	NNP
cord-001835-0s7ok4uw	858	14	1	1	CD
cord-001835-0s7ok4uw	858	15	,	,	,
cord-001835-0s7ok4uw	858	16	Kevin	Kevin	NNP
cord-001835-0s7ok4uw	858	17	Ramos	Ramos	NNP
cord-001835-0s7ok4uw	858	18	1	1	CD
cord-001835-0s7ok4uw	858	19	,	,	,
cord-001835-0s7ok4uw	858	20	Nicholas	Nicholas	NNP
cord-001835-0s7ok4uw	858	21	DeLateur	DeLateur	NNP
cord-001835-0s7ok4uw	858	22	1	1	CD
cord-001835-0s7ok4uw	858	23	,	,	,
cord-001835-0s7ok4uw	858	24	Penny	Penny	NNP
cord-001835-0s7ok4uw	858	25	Beuning	Beuning	NNP
cord-001835-0s7ok4uw	858	26	1	1	CD
cord-001835-0s7ok4uw	858	27	,	,	,
cord-001835-0s7ok4uw	858	28	Mary	Mary	NNP
cord-001835-0s7ok4uw	858	29	Jo	Jo	NNP
cord-001835-0s7ok4uw	858	30	Ondrechen	Ondrechen	NNP
cord-001835-0s7ok4uw	858	31	1	1	CD
cord-001835-0s7ok4uw	858	32	1	1	CD
cord-001835-0s7ok4uw	858	33	Understanding	understanding	NN
cord-001835-0s7ok4uw	858	34	how	how	WRB
cord-001835-0s7ok4uw	858	35	an	an	DT
cord-001835-0s7ok4uw	858	36	enzyme	enzyme	NN
cord-001835-0s7ok4uw	858	37	catalyzes	catalyze	VBZ
cord-001835-0s7ok4uw	858	38	a	a	DT
cord-001835-0s7ok4uw	858	39	reaction	reaction	NN
cord-001835-0s7ok4uw	858	40	is	be	VBZ
cord-001835-0s7ok4uw	858	41	a	a	DT
cord-001835-0s7ok4uw	858	42	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	858	43	problem	problem	NN
cord-001835-0s7ok4uw	858	44	in	in	IN
cord-001835-0s7ok4uw	858	45	protein	protein	NN
cord-001835-0s7ok4uw	858	46	science	science	NN
cord-001835-0s7ok4uw	858	47	.	.	.
cord-001835-0s7ok4uw	859	1	Biochemical	biochemical	JJ
cord-001835-0s7ok4uw	859	2	experimentation	experimentation	NN
cord-001835-0s7ok4uw	859	3	has	have	VBZ
cord-001835-0s7ok4uw	859	4	revealed	reveal	VBN
cord-001835-0s7ok4uw	859	5	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	859	6	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	859	7	of	of	IN
cord-001835-0s7ok4uw	859	8	many	many	JJ
cord-001835-0s7ok4uw	859	9	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	859	10	;	;	:
cord-001835-0s7ok4uw	859	11	however	however	RB
cord-001835-0s7ok4uw	859	12	these	these	DT
cord-001835-0s7ok4uw	859	13	studies	study	NNS
cord-001835-0s7ok4uw	859	14	have	have	VBP
cord-001835-0s7ok4uw	859	15	focused	focus	VBN
cord-001835-0s7ok4uw	859	16	almost	almost	RB
cord-001835-0s7ok4uw	859	17	exclusively	exclusively	RB
cord-001835-0s7ok4uw	859	18	on	on	IN
cord-001835-0s7ok4uw	859	19	amino	amino	NN
cord-001835-0s7ok4uw	859	20	acid	acid	NN
cord-001835-0s7ok4uw	859	21	residues	residue	NNS
cord-001835-0s7ok4uw	859	22	in	in	IN
cord-001835-0s7ok4uw	859	23	direct	direct	JJ
cord-001835-0s7ok4uw	859	24	contact	contact	NN
cord-001835-0s7ok4uw	859	25	with	with	IN
cord-001835-0s7ok4uw	859	26	the	the	DT
cord-001835-0s7ok4uw	859	27	reacting	react	VBG
cord-001835-0s7ok4uw	859	28	substrate	substrate	NN
cord-001835-0s7ok4uw	859	29	molecule(s	molecule(s	NNP
cord-001835-0s7ok4uw	859	30	)	)	-RRB-
cord-001835-0s7ok4uw	859	31	.	.	.
cord-001835-0s7ok4uw	860	1	Here	here	RB
cord-001835-0s7ok4uw	860	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	860	3	report	report	VBP
cord-001835-0s7ok4uw	860	4	on	on	IN
cord-001835-0s7ok4uw	860	5	the	the	DT
cord-001835-0s7ok4uw	860	6	computational	computational	JJ
cord-001835-0s7ok4uw	860	7	prediction	prediction	NN
cord-001835-0s7ok4uw	860	8	and	and	CC
cord-001835-0s7ok4uw	860	9	experimental	experimental	JJ
cord-001835-0s7ok4uw	860	10	verification	verification	NN
cord-001835-0s7ok4uw	860	11	of	of	IN
cord-001835-0s7ok4uw	860	12	the	the	DT
cord-001835-0s7ok4uw	860	13	importance	importance	NN
cord-001835-0s7ok4uw	860	14	of	of	IN
cord-001835-0s7ok4uw	860	15	distal	distal	JJ
cord-001835-0s7ok4uw	860	16	residues	residue	NNS
cord-001835-0s7ok4uw	860	17	in	in	IN
cord-001835-0s7ok4uw	860	18	enzyme	enzyme	NN
cord-001835-0s7ok4uw	860	19	catalysis	catalysis	NN
cord-001835-0s7ok4uw	860	20	,	,	,
cord-001835-0s7ok4uw	860	21	using	use	VBG
cord-001835-0s7ok4uw	860	22	E.	E.	NNP
cord-001835-0s7ok4uw	860	23	coli	coli	NNS
cord-001835-0s7ok4uw	860	24	ornithine	ornithine	NN
cord-001835-0s7ok4uw	860	25	transcarbamylase	transcarbamylase	NN
cord-001835-0s7ok4uw	860	26	as	as	IN
cord-001835-0s7ok4uw	860	27	an	an	DT
cord-001835-0s7ok4uw	860	28	example	example	NN
cord-001835-0s7ok4uw	860	29	.	.	.
cord-001835-0s7ok4uw	861	1	Partial	partial	JJ
cord-001835-0s7ok4uw	861	2	Order	order	NN
cord-001835-0s7ok4uw	861	3	Optimum	optimum	JJ
cord-001835-0s7ok4uw	861	4	Likelihood	Likelihood	NNP
cord-001835-0s7ok4uw	861	5	(	(	-LRB-
cord-001835-0s7ok4uw	861	6	POOL	pool	NN
cord-001835-0s7ok4uw	861	7	)	)	-RRB-
cord-001835-0s7ok4uw	861	8	,	,	,
cord-001835-0s7ok4uw	861	9	developed	develop	VBN
cord-001835-0s7ok4uw	861	10	at	at	IN
cord-001835-0s7ok4uw	861	11	Northeastern	Northeastern	NNP
cord-001835-0s7ok4uw	861	12	University	University	NNP
cord-001835-0s7ok4uw	861	13	,	,	,
cord-001835-0s7ok4uw	861	14	is	be	VBZ
cord-001835-0s7ok4uw	861	15	a	a	DT
cord-001835-0s7ok4uw	861	16	machine	machine	NN
cord-001835-0s7ok4uw	861	17	learning	learning	NN
cord-001835-0s7ok4uw	861	18	technique	technique	NN
cord-001835-0s7ok4uw	861	19	that	that	WDT
cord-001835-0s7ok4uw	861	20	only	only	RB
cord-001835-0s7ok4uw	861	21	requires	require	VBZ
cord-001835-0s7ok4uw	861	22	the	the	DT
cord-001835-0s7ok4uw	861	23	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	861	24	structure	structure	NN
cord-001835-0s7ok4uw	861	25	of	of	IN
cord-001835-0s7ok4uw	861	26	a	a	DT
cord-001835-0s7ok4uw	861	27	protein	protein	NN
cord-001835-0s7ok4uw	861	28	to	to	TO
cord-001835-0s7ok4uw	861	29	predict	predict	VB
cord-001835-0s7ok4uw	861	30	important	important	JJ
cord-001835-0s7ok4uw	861	31	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	861	32	residues	residue	NNS
cord-001835-0s7ok4uw	861	33	,	,	,
cord-001835-0s7ok4uw	861	34	based	base	VBN
cord-001835-0s7ok4uw	861	35	on	on	IN
cord-001835-0s7ok4uw	861	36	computed	compute	VBN
cord-001835-0s7ok4uw	861	37	,	,	,
cord-001835-0s7ok4uw	861	38	residue	residue	NN
cord-001835-0s7ok4uw	861	39	-	-	HYPH
cord-001835-0s7ok4uw	861	40	specific	specific	JJ
cord-001835-0s7ok4uw	861	41	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	861	42	and	and	CC
cord-001835-0s7ok4uw	861	43	chemical	chemical	JJ
cord-001835-0s7ok4uw	861	44	properties	property	NNS
cord-001835-0s7ok4uw	861	45	.	.	.
cord-001835-0s7ok4uw	862	1	POOL	pool	NN
cord-001835-0s7ok4uw	862	2	has	have	VBZ
cord-001835-0s7ok4uw	862	3	been	be	VBN
cord-001835-0s7ok4uw	862	4	shown	show	VBN
cord-001835-0s7ok4uw	862	5	to	to	TO
cord-001835-0s7ok4uw	862	6	predict	predict	VB
cord-001835-0s7ok4uw	862	7	accurately	accurately	RB
cord-001835-0s7ok4uw	862	8	the	the	DT
cord-001835-0s7ok4uw	862	9	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	862	10	residues	residue	NNS
cord-001835-0s7ok4uw	862	11	and	and	CC
cord-001835-0s7ok4uw	862	12	to	to	TO
cord-001835-0s7ok4uw	862	13	discern	discern	VB
cord-001835-0s7ok4uw	862	14	between	between	IN
cord-001835-0s7ok4uw	862	15	compact	compact	JJ
cord-001835-0s7ok4uw	862	16	and	and	CC
cord-001835-0s7ok4uw	862	17	spatially	spatially	RB
cord-001835-0s7ok4uw	862	18	extended	extend	VBN
cord-001835-0s7ok4uw	862	19	active	active	JJ
cord-001835-0s7ok4uw	862	20	sites	site	NNS
cord-001835-0s7ok4uw	862	21	.	.	.
cord-001835-0s7ok4uw	863	1	Dynamic	dynamic	JJ
cord-001835-0s7ok4uw	863	2	conformational	conformational	JJ
cord-001835-0s7ok4uw	863	3	changes	change	NNS
cord-001835-0s7ok4uw	863	4	during	during	IN
cord-001835-0s7ok4uw	863	5	catalysis	catalysis	NN
cord-001835-0s7ok4uw	863	6	and	and	CC
cord-001835-0s7ok4uw	863	7	strong	strong	JJ
cord-001835-0s7ok4uw	863	8	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	863	9	interactions	interaction	NNS
cord-001835-0s7ok4uw	863	10	give	give	VBP
cord-001835-0s7ok4uw	863	11	rise	rise	NN
cord-001835-0s7ok4uw	863	12	to	to	IN
cord-001835-0s7ok4uw	863	13	significant	significant	JJ
cord-001835-0s7ok4uw	863	14	coupling	coupling	NN
cord-001835-0s7ok4uw	863	15	between	between	IN
cord-001835-0s7ok4uw	863	16	remote	remote	JJ
cord-001835-0s7ok4uw	863	17	residues	residue	NNS
cord-001835-0s7ok4uw	863	18	and	and	CC
cord-001835-0s7ok4uw	863	19	the	the	DT
cord-001835-0s7ok4uw	863	20	canonical	canonical	JJ
cord-001835-0s7ok4uw	863	21	active	active	JJ
cord-001835-0s7ok4uw	863	22	site	site	NN
cord-001835-0s7ok4uw	863	23	residues	residue	NNS
cord-001835-0s7ok4uw	863	24	of	of	IN
cord-001835-0s7ok4uw	863	25	an	an	DT
cord-001835-0s7ok4uw	863	26	enzyme	enzyme	NN
cord-001835-0s7ok4uw	863	27	.	.	.
cord-001835-0s7ok4uw	864	1	This	this	DT
cord-001835-0s7ok4uw	864	2	suggests	suggest	VBZ
cord-001835-0s7ok4uw	864	3	that	that	IN
cord-001835-0s7ok4uw	864	4	at	at	IN
cord-001835-0s7ok4uw	864	5	least	least	JJS
cord-001835-0s7ok4uw	864	6	some	some	DT
cord-001835-0s7ok4uw	864	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	864	8	active	active	JJ
cord-001835-0s7ok4uw	864	9	sites	site	NNS
cord-001835-0s7ok4uw	864	10	are	be	VBP
cord-001835-0s7ok4uw	864	11	spatially	spatially	RB
cord-001835-0s7ok4uw	864	12	extended	extend	VBN
cord-001835-0s7ok4uw	864	13	,	,	,
cord-001835-0s7ok4uw	864	14	with	with	IN
cord-001835-0s7ok4uw	864	15	second	second	JJ
cord-001835-0s7ok4uw	864	16	-	-	HYPH
cord-001835-0s7ok4uw	864	17	and	and	CC
cord-001835-0s7ok4uw	864	18	third	third	JJ
cord-001835-0s7ok4uw	864	19	-	-	HYPH
cord-001835-0s7ok4uw	864	20	shell	shell	NN
cord-001835-0s7ok4uw	864	21	residues	residue	NNS
cord-001835-0s7ok4uw	864	22	playing	play	VBG
cord-001835-0s7ok4uw	864	23	significant	significant	JJ
cord-001835-0s7ok4uw	864	24	roles	role	NNS
cord-001835-0s7ok4uw	864	25	in	in	IN
cord-001835-0s7ok4uw	864	26	catalysis	catalysis	NN
cord-001835-0s7ok4uw	864	27	.	.	.
cord-001835-0s7ok4uw	865	1	In	in	IN
cord-001835-0s7ok4uw	865	2	this	this	DT
cord-001835-0s7ok4uw	865	3	project	project	NN
cord-001835-0s7ok4uw	865	4	,	,	,
cord-001835-0s7ok4uw	865	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	865	6	focus	focus	VBP
cord-001835-0s7ok4uw	865	7	on	on	IN
cord-001835-0s7ok4uw	865	8	ornithine	ornithine	NN
cord-001835-0s7ok4uw	865	9	transcarbamylase	transcarbamylase	NN
cord-001835-0s7ok4uw	865	10	(	(	-LRB-
cord-001835-0s7ok4uw	865	11	OTC	OTC	NNP
cord-001835-0s7ok4uw	865	12	)	)	-RRB-
cord-001835-0s7ok4uw	865	13	,	,	,
cord-001835-0s7ok4uw	865	14	for	for	IN
cord-001835-0s7ok4uw	865	15	which	which	WDT
cord-001835-0s7ok4uw	865	16	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	865	17	processes	process	NNS
cord-001835-0s7ok4uw	865	18	are	be	VBP
cord-001835-0s7ok4uw	865	19	believed	believe	VBN
cord-001835-0s7ok4uw	865	20	to	to	TO
cord-001835-0s7ok4uw	865	21	play	play	VB
cord-001835-0s7ok4uw	865	22	a	a	DT
cord-001835-0s7ok4uw	865	23	role	role	NN
cord-001835-0s7ok4uw	865	24	in	in	IN
cord-001835-0s7ok4uw	865	25	its	-PRON-	PRP$
cord-001835-0s7ok4uw	865	26	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	865	27	mechanism	mechanism	NN
cord-001835-0s7ok4uw	865	28	.	.	.
cord-001835-0s7ok4uw	866	1	OTC	OTC	NNP
cord-001835-0s7ok4uw	866	2	is	be	VBZ
cord-001835-0s7ok4uw	866	3	reported	report	VBN
cord-001835-0s7ok4uw	866	4	to	to	TO
cord-001835-0s7ok4uw	866	5	undergo	undergo	VB
cord-001835-0s7ok4uw	866	6	induced	induce	VBN
cord-001835-0s7ok4uw	866	7	-	-	HYPH
cord-001835-0s7ok4uw	866	8	fit	fit	JJ
cord-001835-0s7ok4uw	866	9	conformational	conformational	JJ
cord-001835-0s7ok4uw	866	10	changes	change	NNS
cord-001835-0s7ok4uw	866	11	upon	upon	IN
cord-001835-0s7ok4uw	866	12	binding	bind	VBG
cord-001835-0s7ok4uw	866	13	carbamoyl	carbamoyl	NN
cord-001835-0s7ok4uw	866	14	phosphate	phosphate	NN
cord-001835-0s7ok4uw	866	15	,	,	,
cord-001835-0s7ok4uw	866	16	which	which	WDT
cord-001835-0s7ok4uw	866	17	affects	affect	VBZ
cord-001835-0s7ok4uw	866	18	the	the	DT
cord-001835-0s7ok4uw	866	19	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	866	20	binding	binding	NN
cord-001835-0s7ok4uw	866	21	of	of	IN
cord-001835-0s7ok4uw	866	22	ornithine	ornithine	NN
cord-001835-0s7ok4uw	866	23	.	.	.
cord-001835-0s7ok4uw	867	1	Residues	residue	NNS
cord-001835-0s7ok4uw	867	2	predicted	predict	VBN
cord-001835-0s7ok4uw	867	3	by	by	IN
cord-001835-0s7ok4uw	867	4	POOL	pool	NN
cord-001835-0s7ok4uw	867	5	to	to	TO
cord-001835-0s7ok4uw	867	6	be	be	VB
cord-001835-0s7ok4uw	867	7	catalytically	catalytically	RB
cord-001835-0s7ok4uw	867	8	important	important	JJ
cord-001835-0s7ok4uw	867	9	include	include	VBP
cord-001835-0s7ok4uw	867	10	five	five	CD
cord-001835-0s7ok4uw	867	11	in	in	IN
cord-001835-0s7ok4uw	867	12	direct	direct	JJ
cord-001835-0s7ok4uw	867	13	contact	contact	NN
cord-001835-0s7ok4uw	867	14	with	with	IN
cord-001835-0s7ok4uw	867	15	the	the	DT
cord-001835-0s7ok4uw	867	16	substrate	substrate	NN
cord-001835-0s7ok4uw	867	17	,	,	,
cord-001835-0s7ok4uw	867	18	R106	R106	NNPS
cord-001835-0s7ok4uw	867	19	,	,	,
cord-001835-0s7ok4uw	867	20	H133	H133	NNP
cord-001835-0s7ok4uw	867	21	,	,	,
cord-001835-0s7ok4uw	867	22	D231	D231	NNP
cord-001835-0s7ok4uw	867	23	,	,	,
cord-001835-0s7ok4uw	867	24	C273	C273	NNPS
cord-001835-0s7ok4uw	867	25	and	and	CC
cord-001835-0s7ok4uw	867	26	R319	r319	NN
cord-001835-0s7ok4uw	867	27	.	.	.
cord-001835-0s7ok4uw	868	1	POOL	pool	NN
cord-001835-0s7ok4uw	868	2	also	also	RB
cord-001835-0s7ok4uw	868	3	predicted	predict	VBD
cord-001835-0s7ok4uw	868	4	remote	remote	JJ
cord-001835-0s7ok4uw	868	5	residues	residue	NNS
cord-001835-0s7ok4uw	868	6	to	to	TO
cord-001835-0s7ok4uw	868	7	form	form	VB
cord-001835-0s7ok4uw	868	8	a	a	DT
cord-001835-0s7ok4uw	868	9	spatially	spatially	RB
cord-001835-0s7ok4uw	868	10	extended	extended	JJ
cord-001835-0s7ok4uw	868	11	,	,	,
cord-001835-0s7ok4uw	868	12	triple	triple	JJ
cord-001835-0s7ok4uw	868	13	-	-	HYPH
cord-001835-0s7ok4uw	868	14	layer	layer	NN
cord-001835-0s7ok4uw	868	15	active	active	JJ
cord-001835-0s7ok4uw	868	16	site	site	NN
cord-001835-0s7ok4uw	868	17	.	.	.
cord-001835-0s7ok4uw	869	1	Guided	guide	VBN
cord-001835-0s7ok4uw	869	2	by	by	IN
cord-001835-0s7ok4uw	869	3	computational	computational	JJ
cord-001835-0s7ok4uw	869	4	predictions	prediction	NNS
cord-001835-0s7ok4uw	869	5	and	and	CC
cord-001835-0s7ok4uw	869	6	using	use	VBG
cord-001835-0s7ok4uw	869	7	site	site	NN
cord-001835-0s7ok4uw	869	8	-	-	HYPH
cord-001835-0s7ok4uw	869	9	directed	direct	VBN
cord-001835-0s7ok4uw	869	10	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	869	11	and	and	CC
cord-001835-0s7ok4uw	869	12	kinetics	kinetics	NN
cord-001835-0s7ok4uw	869	13	assays	assay	NNS
cord-001835-0s7ok4uw	869	14	of	of	IN
cord-001835-0s7ok4uw	869	15	Asp140	asp140	CD
cord-001835-0s7ok4uw	869	16	,	,	,
cord-001835-0s7ok4uw	869	17	His272	his272	CD
cord-001835-0s7ok4uw	869	18	,	,	,
cord-001835-0s7ok4uw	869	19	Glu299	Glu299	NNP
cord-001835-0s7ok4uw	870	1	and	and	CC
cord-001835-0s7ok4uw	870	2	Arg57	Arg57	NNP
cord-001835-0s7ok4uw	870	3	variants	variant	NNS
cord-001835-0s7ok4uw	870	4	,	,	,
cord-001835-0s7ok4uw	870	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	870	6	show	show	VBP
cord-001835-0s7ok4uw	870	7	that	that	IN
cord-001835-0s7ok4uw	870	8	these	these	DT
cord-001835-0s7ok4uw	870	9	POOL	pool	NN
cord-001835-0s7ok4uw	870	10	-	-	HYPH
cord-001835-0s7ok4uw	870	11	predicted	predict	VBN
cord-001835-0s7ok4uw	870	12	remote	remote	JJ
cord-001835-0s7ok4uw	870	13	residues	residue	NNS
cord-001835-0s7ok4uw	870	14	,	,	,
cord-001835-0s7ok4uw	870	15	located	locate	VBN
cord-001835-0s7ok4uw	870	16	in	in	IN
cord-001835-0s7ok4uw	870	17	the	the	DT
cord-001835-0s7ok4uw	870	18	second	second	JJ
cord-001835-0s7ok4uw	870	19	and	and	CC
cord-001835-0s7ok4uw	870	20	third	third	JJ
cord-001835-0s7ok4uw	870	21	layers	layer	NNS
cord-001835-0s7ok4uw	870	22	,	,	,
cord-001835-0s7ok4uw	870	23	are	be	VBP
cord-001835-0s7ok4uw	870	24	important	important	JJ
cord-001835-0s7ok4uw	870	25	for	for	IN
cord-001835-0s7ok4uw	870	26	catalysis	catalysis	NN
cord-001835-0s7ok4uw	870	27	.	.	.
cord-001835-0s7ok4uw	870	28	 	 	_SP
cord-001835-0s7ok4uw	871	1	Alternative	alternative	JJ
cord-001835-0s7ok4uw	871	2	energy	energy	NN
cord-001835-0s7ok4uw	871	3	is	be	VBZ
cord-001835-0s7ok4uw	871	4	a	a	DT
cord-001835-0s7ok4uw	871	5	major	major	JJ
cord-001835-0s7ok4uw	871	6	focus	focus	NN
cord-001835-0s7ok4uw	871	7	of	of	IN
cord-001835-0s7ok4uw	871	8	current	current	JJ
cord-001835-0s7ok4uw	871	9	research	research	NN
cord-001835-0s7ok4uw	871	10	efforts	effort	NNS
cord-001835-0s7ok4uw	871	11	.	.	.
cord-001835-0s7ok4uw	872	1	Biodiesel	biodiesel	NN
cord-001835-0s7ok4uw	872	2	,	,	,
cord-001835-0s7ok4uw	872	3	a	a	DT
cord-001835-0s7ok4uw	872	4	mixture	mixture	NN
cord-001835-0s7ok4uw	872	5	of	of	IN
cord-001835-0s7ok4uw	872	6	fatty	fatty	JJ
cord-001835-0s7ok4uw	872	7	acid	acid	NN
cord-001835-0s7ok4uw	872	8	alkyl	alkyl	NN
cord-001835-0s7ok4uw	872	9	esters	ester	NNS
cord-001835-0s7ok4uw	872	10	,	,	,
cord-001835-0s7ok4uw	872	11	is	be	VBZ
cord-001835-0s7ok4uw	872	12	one	one	CD
cord-001835-0s7ok4uw	872	13	of	of	IN
cord-001835-0s7ok4uw	872	14	the	the	DT
cord-001835-0s7ok4uw	872	15	most	most	RBS
cord-001835-0s7ok4uw	872	16	versatile	versatile	JJ
cord-001835-0s7ok4uw	872	17	alternative	alternative	JJ
cord-001835-0s7ok4uw	872	18	fuels	fuel	NNS
cord-001835-0s7ok4uw	872	19	currently	currently	RB
cord-001835-0s7ok4uw	872	20	in	in	IN
cord-001835-0s7ok4uw	872	21	use	use	NN
cord-001835-0s7ok4uw	872	22	.	.	.
cord-001835-0s7ok4uw	873	1	This	this	DT
cord-001835-0s7ok4uw	873	2	is	be	VBZ
cord-001835-0s7ok4uw	873	3	due	due	JJ
cord-001835-0s7ok4uw	873	4	to	to	IN
cord-001835-0s7ok4uw	873	5	the	the	DT
cord-001835-0s7ok4uw	873	6	fact	fact	NN
cord-001835-0s7ok4uw	873	7	that	that	IN
cord-001835-0s7ok4uw	873	8	it	-PRON-	PRP
cord-001835-0s7ok4uw	873	9	is	be	VBZ
cord-001835-0s7ok4uw	873	10	similar	similar	JJ
cord-001835-0s7ok4uw	873	11	to	to	IN
cord-001835-0s7ok4uw	873	12	gasoline	gasoline	NN
cord-001835-0s7ok4uw	873	13	and	and	CC
cord-001835-0s7ok4uw	873	14	compatible	compatible	JJ
cord-001835-0s7ok4uw	873	15	with	with	IN
cord-001835-0s7ok4uw	873	16	diesel	diesel	NN
cord-001835-0s7ok4uw	873	17	engines	engine	NNS
cord-001835-0s7ok4uw	873	18	found	find	VBN
cord-001835-0s7ok4uw	873	19	throughout	throughout	IN
cord-001835-0s7ok4uw	873	20	the	the	DT
cord-001835-0s7ok4uw	873	21	existing	exist	VBG
cord-001835-0s7ok4uw	873	22	global	global	JJ
cord-001835-0s7ok4uw	873	23	infrastructure	infrastructure	NN
cord-001835-0s7ok4uw	873	24	.	.	.
cord-001835-0s7ok4uw	874	1	Biodiesel	biodiesel	NN
cord-001835-0s7ok4uw	874	2	precursor	precursor	NN
cord-001835-0s7ok4uw	874	3	lipids	lipid	NNS
cord-001835-0s7ok4uw	874	4	are	be	VBP
cord-001835-0s7ok4uw	874	5	abundant	abundant	JJ
cord-001835-0s7ok4uw	874	6	in	in	IN
cord-001835-0s7ok4uw	874	7	cultivated	cultivate	VBN
cord-001835-0s7ok4uw	874	8	feedstock	feedstock	NN
cord-001835-0s7ok4uw	874	9	organisms	organism	NNS
cord-001835-0s7ok4uw	874	10	such	such	JJ
cord-001835-0s7ok4uw	874	11	as	as	IN
cord-001835-0s7ok4uw	874	12	algae	algae	NN
cord-001835-0s7ok4uw	874	13	and	and	CC
cord-001835-0s7ok4uw	874	14	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	874	15	.	.	.
cord-001835-0s7ok4uw	875	1	However	however	RB
cord-001835-0s7ok4uw	875	2	,	,	,
cord-001835-0s7ok4uw	875	3	the	the	DT
cord-001835-0s7ok4uw	875	4	standard	standard	JJ
cord-001835-0s7ok4uw	875	5	process	process	NN
cord-001835-0s7ok4uw	875	6	for	for	IN
cord-001835-0s7ok4uw	875	7	converting	convert	VBG
cord-001835-0s7ok4uw	875	8	oil	oil	NN
cord-001835-0s7ok4uw	875	9	to	to	IN
cord-001835-0s7ok4uw	875	10	biodiesel	biodiesel	NN
cord-001835-0s7ok4uw	875	11	is	be	VBZ
cord-001835-0s7ok4uw	875	12	heat	heat	NN
cord-001835-0s7ok4uw	875	13	-	-	HYPH
cord-001835-0s7ok4uw	875	14	intensive	intensive	JJ
cord-001835-0s7ok4uw	875	15	and	and	CC
cord-001835-0s7ok4uw	875	16	requires	require	VBZ
cord-001835-0s7ok4uw	875	17	complete	complete	JJ
cord-001835-0s7ok4uw	875	18	removal	removal	NN
cord-001835-0s7ok4uw	875	19	of	of	IN
cord-001835-0s7ok4uw	875	20	water	water	NN
cord-001835-0s7ok4uw	875	21	,	,	,
cord-001835-0s7ok4uw	875	22	reducing	reduce	VBG
cord-001835-0s7ok4uw	875	23	the	the	DT
cord-001835-0s7ok4uw	875	24	overall	overall	JJ
cord-001835-0s7ok4uw	875	25	net	net	JJ
cord-001835-0s7ok4uw	875	26	energy	energy	NN
cord-001835-0s7ok4uw	875	27	gained	gain	VBN
cord-001835-0s7ok4uw	875	28	in	in	IN
cord-001835-0s7ok4uw	875	29	its	-PRON-	PRP$
cord-001835-0s7ok4uw	875	30	production	production	NN
cord-001835-0s7ok4uw	875	31	.	.	.
cord-001835-0s7ok4uw	876	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	876	2	work	work	NN
cord-001835-0s7ok4uw	876	3	constitutes	constitute	VBZ
cord-001835-0s7ok4uw	876	4	an	an	DT
cord-001835-0s7ok4uw	876	5	attempt	attempt	NN
cord-001835-0s7ok4uw	876	6	to	to	TO
cord-001835-0s7ok4uw	876	7	explore	explore	VB
cord-001835-0s7ok4uw	876	8	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	876	9	synthesis	synthesis	NN
cord-001835-0s7ok4uw	876	10	of	of	IN
cord-001835-0s7ok4uw	876	11	biodiesel	biodiesel	NN
cord-001835-0s7ok4uw	876	12	from	from	IN
cord-001835-0s7ok4uw	876	13	lipids	lipid	NNS
cord-001835-0s7ok4uw	876	14	such	such	JJ
cord-001835-0s7ok4uw	876	15	as	as	IN
cord-001835-0s7ok4uw	876	16	those	those	DT
cord-001835-0s7ok4uw	876	17	derived	derive	VBN
cord-001835-0s7ok4uw	876	18	from	from	IN
cord-001835-0s7ok4uw	876	19	emerging	emerge	VBG
cord-001835-0s7ok4uw	876	20	fuel	fuel	NN
cord-001835-0s7ok4uw	876	21	crops	crop	NNS
cord-001835-0s7ok4uw	876	22	.	.	.
cord-001835-0s7ok4uw	877	1	Previous	previous	JJ
cord-001835-0s7ok4uw	877	2	literature	literature	NN
cord-001835-0s7ok4uw	877	3	describes	describe	VBZ
cord-001835-0s7ok4uw	877	4	fatty	fatty	JJ
cord-001835-0s7ok4uw	877	5	acid	acid	NN
cord-001835-0s7ok4uw	877	6	alkyl	alkyl	NN
cord-001835-0s7ok4uw	877	7	ester	ester	NN
cord-001835-0s7ok4uw	877	8	formation	formation	NN
cord-001835-0s7ok4uw	877	9	in	in	IN
cord-001835-0s7ok4uw	877	10	human	human	JJ
cord-001835-0s7ok4uw	877	11	patients	patient	NNS
cord-001835-0s7ok4uw	877	12	with	with	IN
cord-001835-0s7ok4uw	877	13	MRSA	MRSA	NNP
cord-001835-0s7ok4uw	877	14	Staphylococcus	Staphylococcus	NNP
cord-001835-0s7ok4uw	877	15	aureus	aureus	NN
cord-001835-0s7ok4uw	877	16	wound	wind	VBD
cord-001835-0s7ok4uw	877	17	lesions	lesion	NNS
cord-001835-0s7ok4uw	877	18	.	.	.
cord-001835-0s7ok4uw	878	1	These	these	DT
cord-001835-0s7ok4uw	878	2	esters	ester	NNS
cord-001835-0s7ok4uw	878	3	are	be	VBP
cord-001835-0s7ok4uw	878	4	formed	form	VBN
cord-001835-0s7ok4uw	878	5	by	by	IN
cord-001835-0s7ok4uw	878	6	partially	partially	RB
cord-001835-0s7ok4uw	878	7	characterized	characterize	VBN
cord-001835-0s7ok4uw	878	8	esterase	esterase	NN
cord-001835-0s7ok4uw	878	9	activity	activity	NN
cord-001835-0s7ok4uw	878	10	from	from	IN
cord-001835-0s7ok4uw	878	11	an	an	DT
cord-001835-0s7ok4uw	878	12	unidentified	unidentified	JJ
cord-001835-0s7ok4uw	878	13	source	source	NN
cord-001835-0s7ok4uw	878	14	.	.	.
cord-001835-0s7ok4uw	879	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	879	2	have	have	VBP
cord-001835-0s7ok4uw	879	3	identified	identify	VBN
cord-001835-0s7ok4uw	879	4	two	two	CD
cord-001835-0s7ok4uw	879	5	MRSA	MRSA	NNP
cord-001835-0s7ok4uw	879	6	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	879	7	responsible	responsible	JJ
cord-001835-0s7ok4uw	879	8	for	for	IN
cord-001835-0s7ok4uw	879	9	this	this	DT
cord-001835-0s7ok4uw	879	10	activity	activity	NN
cord-001835-0s7ok4uw	879	11	by	by	IN
cord-001835-0s7ok4uw	879	12	using	use	VBG
cord-001835-0s7ok4uw	879	13	a	a	DT
cord-001835-0s7ok4uw	879	14	combination	combination	NN
cord-001835-0s7ok4uw	879	15	of	of	IN
cord-001835-0s7ok4uw	879	16	size	size	NN
cord-001835-0s7ok4uw	879	17	exclusion	exclusion	NN
cord-001835-0s7ok4uw	879	18	chromatography	chromatography	NN
cord-001835-0s7ok4uw	879	19	,	,	,
cord-001835-0s7ok4uw	879	20	gas	gas	NN
cord-001835-0s7ok4uw	879	21	chromatography	chromatography	NN
cord-001835-0s7ok4uw	879	22	-	-	HYPH
cord-001835-0s7ok4uw	879	23	mass	mass	NN
cord-001835-0s7ok4uw	879	24	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	879	25	,	,	,
cord-001835-0s7ok4uw	879	26	and	and	CC
cord-001835-0s7ok4uw	879	27	mass	mass	NNP
cord-001835-0s7ok4uw	879	28	spectrometric	spectrometric	NNP
cord-001835-0s7ok4uw	879	29	protein	protein	NN
cord-001835-0s7ok4uw	879	30	sequencing	sequencing	NN
cord-001835-0s7ok4uw	879	31	.	.	.
cord-001835-0s7ok4uw	880	1	These	these	DT
cord-001835-0s7ok4uw	880	2	two	two	CD
cord-001835-0s7ok4uw	880	3	highly	highly	RB
cord-001835-0s7ok4uw	880	4	similar	similar	JJ
cord-001835-0s7ok4uw	880	5	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	880	6	in	in	IN
cord-001835-0s7ok4uw	880	7	the	the	DT
cord-001835-0s7ok4uw	880	8	glycerol	glycerol	NN
cord-001835-0s7ok4uw	880	9	ester	ester	NNP
cord-001835-0s7ok4uw	880	10	hydrolase	hydrolase	NNP
cord-001835-0s7ok4uw	880	11	(	(	-LRB-
cord-001835-0s7ok4uw	880	12	geh	geh	NNP
cord-001835-0s7ok4uw	880	13	)	)	-RRB-
cord-001835-0s7ok4uw	880	14	family	family	NN
cord-001835-0s7ok4uw	880	15	of	of	IN
cord-001835-0s7ok4uw	880	16	proteins	protein	NNS
cord-001835-0s7ok4uw	880	17	catalyze	catalyze	VBP
cord-001835-0s7ok4uw	880	18	the	the	DT
cord-001835-0s7ok4uw	880	19	synthesis	synthesis	NN
cord-001835-0s7ok4uw	880	20	of	of	IN
cord-001835-0s7ok4uw	880	21	fatty	fatty	JJ
cord-001835-0s7ok4uw	880	22	acid	acid	NN
cord-001835-0s7ok4uw	880	23	alkyl	alkyl	NN
cord-001835-0s7ok4uw	880	24	esters	ester	NNS
cord-001835-0s7ok4uw	880	25	in	in	IN
cord-001835-0s7ok4uw	880	26	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	880	27	conditions	condition	NNS
cord-001835-0s7ok4uw	880	28	at	at	IN
cord-001835-0s7ok4uw	880	29	or	or	CC
cord-001835-0s7ok4uw	880	30	near	near	IN
cord-001835-0s7ok4uw	880	31	room	room	NN
cord-001835-0s7ok4uw	880	32	temperature	temperature	NN
cord-001835-0s7ok4uw	880	33	.	.	.
cord-001835-0s7ok4uw	881	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	881	2	have	have	VBP
cord-001835-0s7ok4uw	881	3	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	881	4	that	that	IN
cord-001835-0s7ok4uw	881	5	other	other	JJ
cord-001835-0s7ok4uw	881	6	non	non	JJ
cord-001835-0s7ok4uw	881	7	-	-	JJ
cord-001835-0s7ok4uw	881	8	Staphylococcal	staphylococcal	JJ
cord-001835-0s7ok4uw	881	9	lipases	lipase	NNS
cord-001835-0s7ok4uw	881	10	do	do	VBP
cord-001835-0s7ok4uw	881	11	not	not	RB
cord-001835-0s7ok4uw	881	12	exhibit	exhibit	VB
cord-001835-0s7ok4uw	881	13	this	this	DT
cord-001835-0s7ok4uw	881	14	behavior	behavior	NN
cord-001835-0s7ok4uw	881	15	.	.	.
cord-001835-0s7ok4uw	882	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	882	2	have	have	VBP
cord-001835-0s7ok4uw	882	3	expressed	express	VBN
cord-001835-0s7ok4uw	882	4	these	these	DT
cord-001835-0s7ok4uw	882	5	Staphylococcal	staphylococcal	JJ
cord-001835-0s7ok4uw	882	6	esterases	esterase	NNS
cord-001835-0s7ok4uw	882	7	in	in	IN
cord-001835-0s7ok4uw	882	8	E.	E.	NNP
cord-001835-0s7ok4uw	882	9	coli	coli	NNS
cord-001835-0s7ok4uw	882	10	,	,	,
cord-001835-0s7ok4uw	882	11	and	and	CC
cord-001835-0s7ok4uw	882	12	shown	show	VBN
cord-001835-0s7ok4uw	882	13	via	via	IN
cord-001835-0s7ok4uw	882	14	gas	gas	NN
cord-001835-0s7ok4uw	882	15	chromatography	chromatography	NN
cord-001835-0s7ok4uw	882	16	that	that	WDT
cord-001835-0s7ok4uw	882	17	the	the	DT
cord-001835-0s7ok4uw	882	18	expressed	express	VBN
cord-001835-0s7ok4uw	882	19	proteins	protein	NNS
cord-001835-0s7ok4uw	882	20	catalyze	catalyze	VBP
cord-001835-0s7ok4uw	882	21	the	the	DT
cord-001835-0s7ok4uw	882	22	formation	formation	NN
cord-001835-0s7ok4uw	882	23	of	of	IN
cord-001835-0s7ok4uw	882	24	fatty	fatty	JJ
cord-001835-0s7ok4uw	882	25	acid	acid	NN
cord-001835-0s7ok4uw	882	26	alkyl	alkyl	NN
cord-001835-0s7ok4uw	882	27	esters	ester	NNS
cord-001835-0s7ok4uw	882	28	.	.	.
cord-001835-0s7ok4uw	883	1	Based	base	VBN
cord-001835-0s7ok4uw	883	2	on	on	IN
cord-001835-0s7ok4uw	883	3	sequence	sequence	NN
cord-001835-0s7ok4uw	883	4	similarity	similarity	NN
cord-001835-0s7ok4uw	883	5	to	to	IN
cord-001835-0s7ok4uw	883	6	homologous	homologous	JJ
cord-001835-0s7ok4uw	883	7	proteins	protein	NNS
cord-001835-0s7ok4uw	883	8	that	that	WDT
cord-001835-0s7ok4uw	883	9	have	have	VBP
cord-001835-0s7ok4uw	883	10	already	already	RB
cord-001835-0s7ok4uw	883	11	been	be	VBN
cord-001835-0s7ok4uw	883	12	crystallized	crystallize	VBN
cord-001835-0s7ok4uw	883	13	,	,	,
cord-001835-0s7ok4uw	883	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	883	15	have	have	VBP
cord-001835-0s7ok4uw	883	16	predicted	predict	VBN
cord-001835-0s7ok4uw	883	17	a	a	DT
cord-001835-0s7ok4uw	883	18	structure	structure	NN
cord-001835-0s7ok4uw	883	19	for	for	IN
cord-001835-0s7ok4uw	883	20	these	these	DT
cord-001835-0s7ok4uw	883	21	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	883	22	and	and	CC
cord-001835-0s7ok4uw	883	23	have	have	VBP
cord-001835-0s7ok4uw	883	24	engineered	engineer	VBN
cord-001835-0s7ok4uw	883	25	mutant	mutant	JJ
cord-001835-0s7ok4uw	883	26	fusions	fusion	NNS
cord-001835-0s7ok4uw	883	27	with	with	IN
cord-001835-0s7ok4uw	883	28	higher	high	JJR
cord-001835-0s7ok4uw	883	29	rates	rate	NNS
cord-001835-0s7ok4uw	883	30	of	of	IN
cord-001835-0s7ok4uw	883	31	catalysis	catalysis	NN
cord-001835-0s7ok4uw	883	32	.	.	.
cord-001835-0s7ok4uw	884	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	884	2	design	design	NN
cord-001835-0s7ok4uw	884	3	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	884	4	is	be	VBZ
cord-001835-0s7ok4uw	884	5	that	that	DT
cord-001835-0s7ok4uw	884	6	increased	increase	VBN
cord-001835-0s7ok4uw	884	7	avidity	avidity	NN
cord-001835-0s7ok4uw	884	8	for	for	IN
cord-001835-0s7ok4uw	884	9	substrate	substrate	NN
cord-001835-0s7ok4uw	884	10	molecules	molecule	NNS
cord-001835-0s7ok4uw	884	11	will	will	MD
cord-001835-0s7ok4uw	884	12	yield	yield	VB
cord-001835-0s7ok4uw	884	13	a	a	DT
cord-001835-0s7ok4uw	884	14	higher	high	JJR
cord-001835-0s7ok4uw	884	15	substrate	substrate	NN
cord-001835-0s7ok4uw	884	16	concentration	concentration	NN
cord-001835-0s7ok4uw	884	17	in	in	IN
cord-001835-0s7ok4uw	884	18	the	the	DT
cord-001835-0s7ok4uw	884	19	vicinity	vicinity	NN
cord-001835-0s7ok4uw	884	20	to	to	IN
cord-001835-0s7ok4uw	884	21	the	the	DT
cord-001835-0s7ok4uw	884	22	enzyme	enzyme	NN
cord-001835-0s7ok4uw	884	23	.	.	.
cord-001835-0s7ok4uw	885	1	To	to	TO
cord-001835-0s7ok4uw	885	2	increase	increase	VB
cord-001835-0s7ok4uw	885	3	substrate	substrate	NN
cord-001835-0s7ok4uw	885	4	concentration	concentration	NN
cord-001835-0s7ok4uw	885	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	885	6	have	have	VBP
cord-001835-0s7ok4uw	885	7	designed	design	VBN
cord-001835-0s7ok4uw	885	8	and	and	CC
cord-001835-0s7ok4uw	885	9	expressed	express	VBN
cord-001835-0s7ok4uw	885	10	one	one	CD
cord-001835-0s7ok4uw	885	11	of	of	IN
cord-001835-0s7ok4uw	885	12	the	the	DT
cord-001835-0s7ok4uw	885	13	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	885	14	as	as	IN
cord-001835-0s7ok4uw	885	15	a	a	DT
cord-001835-0s7ok4uw	885	16	chimeric	chimeric	JJ
cord-001835-0s7ok4uw	885	17	fusion	fusion	NN
cord-001835-0s7ok4uw	885	18	with	with	IN
cord-001835-0s7ok4uw	885	19	the	the	DT
cord-001835-0s7ok4uw	885	20	Drosophila	Drosophila	NNP
cord-001835-0s7ok4uw	885	21	melanogaster	melanogaster	NN
cord-001835-0s7ok4uw	885	22	alcohol	alcohol	NN
cord-001835-0s7ok4uw	885	23	-	-	HYPH
cord-001835-0s7ok4uw	885	24	binding	bind	VBG
cord-001835-0s7ok4uw	885	25	protein	protein	NN
cord-001835-0s7ok4uw	885	26	LUSH	lush	RB
cord-001835-0s7ok4uw	885	27	.	.	.
cord-001835-0s7ok4uw	886	1	GC	GC	NNP
cord-001835-0s7ok4uw	886	2	-	-	HYPH
cord-001835-0s7ok4uw	886	3	MS	MS	NNP
cord-001835-0s7ok4uw	886	4	determination	determination	NN
cord-001835-0s7ok4uw	886	5	of	of	IN
cord-001835-0s7ok4uw	886	6	biodiesel	biodiesel	NN
cord-001835-0s7ok4uw	886	7	production	production	NN
cord-001835-0s7ok4uw	886	8	rate	rate	NN
cord-001835-0s7ok4uw	886	9	indicates	indicate	VBZ
cord-001835-0s7ok4uw	886	10	that	that	IN
cord-001835-0s7ok4uw	886	11	the	the	DT
cord-001835-0s7ok4uw	886	12	chimeric	chimeric	JJ
cord-001835-0s7ok4uw	886	13	fusion	fusion	NN
cord-001835-0s7ok4uw	886	14	has	have	VBZ
cord-001835-0s7ok4uw	886	15	a	a	DT
cord-001835-0s7ok4uw	886	16	lower	low	JJR
cord-001835-0s7ok4uw	886	17	-	-	HYPH
cord-001835-0s7ok4uw	886	18	order	order	NN
cord-001835-0s7ok4uw	886	19	rate	rate	NN
cord-001835-0s7ok4uw	886	20	constant	constant	JJ
cord-001835-0s7ok4uw	886	21	with	with	IN
cord-001835-0s7ok4uw	886	22	respect	respect	NN
cord-001835-0s7ok4uw	886	23	to	to	IN
cord-001835-0s7ok4uw	886	24	ethanol	ethanol	NN
cord-001835-0s7ok4uw	886	25	.	.	.
cord-001835-0s7ok4uw	887	1	In	in	IN
cord-001835-0s7ok4uw	887	2	other	other	JJ
cord-001835-0s7ok4uw	887	3	words	word	NNS
cord-001835-0s7ok4uw	887	4	,	,	,
cord-001835-0s7ok4uw	887	5	the	the	DT
cord-001835-0s7ok4uw	887	6	fusion	fusion	NN
cord-001835-0s7ok4uw	887	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	887	8	is	be	VBZ
cord-001835-0s7ok4uw	887	9	less	less	RBR
cord-001835-0s7ok4uw	887	10	dependent	dependent	JJ
cord-001835-0s7ok4uw	887	11	on	on	IN
cord-001835-0s7ok4uw	887	12	substrate	substrate	JJ
cord-001835-0s7ok4uw	887	13	concentration	concentration	NN
cord-001835-0s7ok4uw	887	14	and	and	CC
cord-001835-0s7ok4uw	887	15	is	be	VBZ
cord-001835-0s7ok4uw	887	16	a	a	DT
cord-001835-0s7ok4uw	887	17	superior	superior	JJ
cord-001835-0s7ok4uw	887	18	catalyst	catalyst	NN
cord-001835-0s7ok4uw	887	19	at	at	IN
cord-001835-0s7ok4uw	887	20	low	low	JJ
cord-001835-0s7ok4uw	887	21	ethanol	ethanol	NN
cord-001835-0s7ok4uw	887	22	concentrations	concentration	NNS
cord-001835-0s7ok4uw	887	23	.	.	.
cord-001835-0s7ok4uw	888	1	This	this	DT
cord-001835-0s7ok4uw	888	2	result	result	NN
cord-001835-0s7ok4uw	888	3	indicates	indicate	VBZ
cord-001835-0s7ok4uw	888	4	that	that	IN
cord-001835-0s7ok4uw	888	5	the	the	DT
cord-001835-0s7ok4uw	888	6	rationally	rationally	RB
cord-001835-0s7ok4uw	888	7	designed	design	VBN
cord-001835-0s7ok4uw	888	8	modification	modification	NN
cord-001835-0s7ok4uw	888	9	of	of	IN
cord-001835-0s7ok4uw	888	10	binding	bind	VBG
cord-001835-0s7ok4uw	888	11	avidity	avidity	NN
cord-001835-0s7ok4uw	888	12	constitutes	constitute	VBZ
cord-001835-0s7ok4uw	888	13	a	a	DT
cord-001835-0s7ok4uw	888	14	potential	potential	JJ
cord-001835-0s7ok4uw	888	15	avenue	avenue	NN
cord-001835-0s7ok4uw	888	16	for	for	IN
cord-001835-0s7ok4uw	888	17	improving	improve	VBG
cord-001835-0s7ok4uw	888	18	the	the	DT
cord-001835-0s7ok4uw	888	19	ability	ability	NN
cord-001835-0s7ok4uw	888	20	of	of	IN
cord-001835-0s7ok4uw	888	21	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	888	22	to	to	TO
cord-001835-0s7ok4uw	888	23	catalyze	catalyze	VB
cord-001835-0s7ok4uw	888	24	reactions	reaction	NNS
cord-001835-0s7ok4uw	888	25	with	with	IN
cord-001835-0s7ok4uw	888	26	low	low	JJ
cord-001835-0s7ok4uw	888	27	-	-	HYPH
cord-001835-0s7ok4uw	888	28	concentration	concentration	NN
cord-001835-0s7ok4uw	888	29	or	or	CC
cord-001835-0s7ok4uw	888	30	low	low	JJ
cord-001835-0s7ok4uw	888	31	-	-	HYPH
cord-001835-0s7ok4uw	888	32	solubility	solubility	NN
cord-001835-0s7ok4uw	888	33	substrates	substrate	NNS
cord-001835-0s7ok4uw	888	34	.	.	.
cord-001835-0s7ok4uw	889	1	Functional	functional	JJ
cord-001835-0s7ok4uw	889	2	elements	element	NNS
cord-001835-0s7ok4uw	889	3	of	of	IN
cord-001835-0s7ok4uw	889	4	a	a	DT
cord-001835-0s7ok4uw	889	5	human	human	JJ
cord-001835-0s7ok4uw	889	6	antizyme	antizyme	NNS
cord-001835-0s7ok4uw	889	7	essential	essential	JJ
cord-001835-0s7ok4uw	889	8	for	for	IN
cord-001835-0s7ok4uw	889	9	binding	bind	VBG
cord-001835-0s7ok4uw	889	10	and	and	CC
cord-001835-0s7ok4uw	889	11	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	889	12	human	human	JJ
cord-001835-0s7ok4uw	889	13	ornithine	ornithine	NN
cord-001835-0s7ok4uw	889	14	decarboxylase	decarboxylase	NN
cord-001835-0s7ok4uw	889	15	Proteases	Proteases	NNP
cord-001835-0s7ok4uw	889	16	are	be	VBP
cord-001835-0s7ok4uw	889	17	ubiquitous	ubiquitous	JJ
cord-001835-0s7ok4uw	889	18	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	889	19	that	that	WDT
cord-001835-0s7ok4uw	889	20	catalyze	catalyze	VBP
cord-001835-0s7ok4uw	889	21	the	the	DT
cord-001835-0s7ok4uw	889	22	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	889	23	of	of	IN
cord-001835-0s7ok4uw	889	24	peptide	peptide	NN
cord-001835-0s7ok4uw	889	25	bonds	bond	NNS
cord-001835-0s7ok4uw	889	26	within	within	IN
cord-001835-0s7ok4uw	889	27	protein	protein	NN
cord-001835-0s7ok4uw	889	28	substrates	substrate	NNS
cord-001835-0s7ok4uw	889	29	;	;	:
cord-001835-0s7ok4uw	889	30	they	-PRON-	PRP
cord-001835-0s7ok4uw	889	31	have	have	VBP
cord-001835-0s7ok4uw	889	32	served	serve	VBN
cord-001835-0s7ok4uw	889	33	as	as	IN
cord-001835-0s7ok4uw	889	34	key	key	JJ
cord-001835-0s7ok4uw	889	35	model	model	NN
cord-001835-0s7ok4uw	889	36	enzymes	enzyme	VBZ
cord-001835-0s7ok4uw	889	37	for	for	IN
cord-001835-0s7ok4uw	889	38	studying	study	VBG
cord-001835-0s7ok4uw	889	39	the	the	DT
cord-001835-0s7ok4uw	889	40	molecular	molecular	JJ
cord-001835-0s7ok4uw	889	41	basis	basis	NN
cord-001835-0s7ok4uw	889	42	for	for	IN
cord-001835-0s7ok4uw	889	43	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	889	44	power	power	NN
cord-001835-0s7ok4uw	889	45	and	and	CC
cord-001835-0s7ok4uw	889	46	specificity	specificity	NN
cord-001835-0s7ok4uw	889	47	.	.	.
cord-001835-0s7ok4uw	890	1	Protease	protease	NN
cord-001835-0s7ok4uw	890	2	substrate	substrate	NN
cord-001835-0s7ok4uw	890	3	specificity	specificity	NN
cord-001835-0s7ok4uw	890	4	is	be	VBZ
cord-001835-0s7ok4uw	890	5	most	most	RBS
cord-001835-0s7ok4uw	890	6	often	often	RB
cord-001835-0s7ok4uw	890	7	defined	define	VBN
cord-001835-0s7ok4uw	890	8	in	in	IN
cord-001835-0s7ok4uw	890	9	terms	term	NNS
cord-001835-0s7ok4uw	890	10	of	of	IN
cord-001835-0s7ok4uw	890	11	linear	linear	JJ
cord-001835-0s7ok4uw	890	12	sequence	sequence	NN
cord-001835-0s7ok4uw	890	13	motifs	motif	NNS
cord-001835-0s7ok4uw	890	14	that	that	WDT
cord-001835-0s7ok4uw	890	15	flank	flank	VBP
cord-001835-0s7ok4uw	890	16	the	the	DT
cord-001835-0s7ok4uw	890	17	cleavage	cleavage	NN
cord-001835-0s7ok4uw	890	18	site	site	NN
cord-001835-0s7ok4uw	890	19	;	;	:
cord-001835-0s7ok4uw	890	20	however	however	RB
cord-001835-0s7ok4uw	890	21	,	,	,
cord-001835-0s7ok4uw	890	22	the	the	DT
cord-001835-0s7ok4uw	890	23	natural	natural	JJ
cord-001835-0s7ok4uw	890	24	substrates	substrate	NNS
cord-001835-0s7ok4uw	890	25	of	of	IN
cord-001835-0s7ok4uw	890	26	proteases	protease	NNS
cord-001835-0s7ok4uw	890	27	are	be	VBP
cord-001835-0s7ok4uw	890	28	proteins	protein	NNS
cord-001835-0s7ok4uw	890	29	with	with	IN
cord-001835-0s7ok4uw	890	30	3-dimensional	3-dimensional	CD
cord-001835-0s7ok4uw	890	31	shapes	shape	NNS
cord-001835-0s7ok4uw	890	32	and	and	CC
cord-001835-0s7ok4uw	890	33	complex	complex	JJ
cord-001835-0s7ok4uw	890	34	conformational	conformational	JJ
cord-001835-0s7ok4uw	890	35	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	890	36	that	that	WDT
cord-001835-0s7ok4uw	890	37	are	be	VBP
cord-001835-0s7ok4uw	890	38	not	not	RB
cord-001835-0s7ok4uw	890	39	well	well	RB
cord-001835-0s7ok4uw	890	40	represented	represent	VBN
cord-001835-0s7ok4uw	890	41	by	by	IN
cord-001835-0s7ok4uw	890	42	1-dimensional	1-dimensional	JJ
cord-001835-0s7ok4uw	890	43	sequence	sequence	NN
cord-001835-0s7ok4uw	890	44	alone	alone	RB
cord-001835-0s7ok4uw	890	45	.	.	.
cord-001835-0s7ok4uw	891	1	These	these	DT
cord-001835-0s7ok4uw	891	2	structural	structural	JJ
cord-001835-0s7ok4uw	891	3	and	and	CC
cord-001835-0s7ok4uw	891	4	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	891	5	properties	property	NNS
cord-001835-0s7ok4uw	891	6	can	can	MD
cord-001835-0s7ok4uw	891	7	impact	impact	VB
cord-001835-0s7ok4uw	891	8	recognition	recognition	NN
cord-001835-0s7ok4uw	891	9	and	and	CC
cord-001835-0s7ok4uw	891	10	binding	binding	NN
cord-001835-0s7ok4uw	891	11	of	of	IN
cord-001835-0s7ok4uw	891	12	substrates	substrate	NNS
cord-001835-0s7ok4uw	891	13	by	by	IN
cord-001835-0s7ok4uw	891	14	proteases	protease	NNS
cord-001835-0s7ok4uw	891	15	,	,	,
cord-001835-0s7ok4uw	891	16	as	as	RB
cord-001835-0s7ok4uw	891	17	well	well	RB
cord-001835-0s7ok4uw	891	18	as	as	IN
cord-001835-0s7ok4uw	891	19	the	the	DT
cord-001835-0s7ok4uw	891	20	efficiency	efficiency	NN
cord-001835-0s7ok4uw	891	21	of	of	IN
cord-001835-0s7ok4uw	891	22	catalysis	catalysis	NN
cord-001835-0s7ok4uw	891	23	itself	-PRON-	PRP
cord-001835-0s7ok4uw	891	24	.	.	.
cord-001835-0s7ok4uw	892	1	In	in	IN
cord-001835-0s7ok4uw	892	2	this	this	DT
cord-001835-0s7ok4uw	892	3	study	study	NN
cord-001835-0s7ok4uw	892	4	,	,	,
cord-001835-0s7ok4uw	892	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	892	6	explore	explore	VBP
cord-001835-0s7ok4uw	892	7	the	the	DT
cord-001835-0s7ok4uw	892	8	importance	importance	NN
cord-001835-0s7ok4uw	892	9	of	of	IN
cord-001835-0s7ok4uw	892	10	substrate	substrate	JJ
cord-001835-0s7ok4uw	892	11	structure	structure	NN
cord-001835-0s7ok4uw	892	12	and	and	CC
cord-001835-0s7ok4uw	892	13	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	892	14	for	for	IN
cord-001835-0s7ok4uw	892	15	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	892	16	using	use	VBG
cord-001835-0s7ok4uw	892	17	as	as	IN
cord-001835-0s7ok4uw	892	18	our	-PRON-	PRP$
cord-001835-0s7ok4uw	892	19	model	model	NN
cord-001835-0s7ok4uw	892	20	the	the	DT
cord-001835-0s7ok4uw	892	21	cleavage	cleavage	NN
cord-001835-0s7ok4uw	892	22	of	of	IN
cord-001835-0s7ok4uw	892	23	the	the	DT
cord-001835-0s7ok4uw	892	24	Kunitz	Kunitz	NNP
cord-001835-0s7ok4uw	892	25	-	-	HYPH
cord-001835-0s7ok4uw	892	26	BPTI	BPTI	NNP
cord-001835-0s7ok4uw	892	27	family	family	NN
cord-001835-0s7ok4uw	892	28	of	of	IN
cord-001835-0s7ok4uw	892	29	canonical	canonical	JJ
cord-001835-0s7ok4uw	892	30	serine	serine	NN
cord-001835-0s7ok4uw	892	31	protease	protease	NN
cord-001835-0s7ok4uw	892	32	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	892	33	by	by	IN
cord-001835-0s7ok4uw	892	34	mesotrypsin	mesotrypsin	NNP
cord-001835-0s7ok4uw	892	35	.	.	.
cord-001835-0s7ok4uw	893	1	Bovine	bovine	JJ
cord-001835-0s7ok4uw	893	2	pancreatic	pancreatic	JJ
cord-001835-0s7ok4uw	893	3	trypsin	trypsin	NN
cord-001835-0s7ok4uw	893	4	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	893	5	(	(	-LRB-
cord-001835-0s7ok4uw	893	6	BPTI	BPTI	NNP
cord-001835-0s7ok4uw	893	7	)	)	-RRB-
cord-001835-0s7ok4uw	893	8	,	,	,
cord-001835-0s7ok4uw	893	9	an	an	DT
cord-001835-0s7ok4uw	893	10	archetypal	archetypal	JJ
cord-001835-0s7ok4uw	893	11	serine	serine	NN
cord-001835-0s7ok4uw	893	12	protease	protease	NN
cord-001835-0s7ok4uw	893	13	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	893	14	of	of	IN
cord-001835-0s7ok4uw	893	15	the	the	DT
cord-001835-0s7ok4uw	893	16	Kunitz	Kunitz	NNP
cord-001835-0s7ok4uw	893	17	family	family	NN
cord-001835-0s7ok4uw	893	18	,	,	,
cord-001835-0s7ok4uw	893	19	has	have	VBZ
cord-001835-0s7ok4uw	893	20	a	a	DT
cord-001835-0s7ok4uw	893	21	high	high	JJ
cord-001835-0s7ok4uw	893	22	affinity	affinity	NN
cord-001835-0s7ok4uw	893	23	interaction	interaction	NN
cord-001835-0s7ok4uw	893	24	with	with	IN
cord-001835-0s7ok4uw	893	25	trypsin	trypsin	NN
cord-001835-0s7ok4uw	893	26	,	,	,
cord-001835-0s7ok4uw	893	27	yet	yet	RB
cord-001835-0s7ok4uw	894	1	its	-PRON-	PRP$
cord-001835-0s7ok4uw	894	2	peptide	peptide	NN
cord-001835-0s7ok4uw	894	3	bond	bond	NN
cord-001835-0s7ok4uw	894	4	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	894	5	is	be	VBZ
cord-001835-0s7ok4uw	894	6	many	many	JJ
cord-001835-0s7ok4uw	894	7	orders	order	NNS
cord-001835-0s7ok4uw	894	8	of	of	IN
cord-001835-0s7ok4uw	894	9	magnitude	magnitude	NN
cord-001835-0s7ok4uw	894	10	slower	slow	JJR
cord-001835-0s7ok4uw	894	11	than	than	IN
cord-001835-0s7ok4uw	894	12	other	other	JJ
cord-001835-0s7ok4uw	894	13	peptide	peptide	NN
cord-001835-0s7ok4uw	894	14	substrates	substrate	NNS
cord-001835-0s7ok4uw	894	15	.	.	.
cord-001835-0s7ok4uw	895	1	Mesotrypsin	Mesotrypsin	NNP
cord-001835-0s7ok4uw	895	2	,	,	,
cord-001835-0s7ok4uw	895	3	a	a	DT
cord-001835-0s7ok4uw	895	4	trypsin	trypsin	NN
cord-001835-0s7ok4uw	895	5	variant	variant	NN
cord-001835-0s7ok4uw	895	6	,	,	,
cord-001835-0s7ok4uw	895	7	has	have	VBZ
cord-001835-0s7ok4uw	895	8	been	be	VBN
cord-001835-0s7ok4uw	895	9	shown	show	VBN
cord-001835-0s7ok4uw	895	10	to	to	TO
cord-001835-0s7ok4uw	895	11	hydrolyze	hydrolyze	VB
cord-001835-0s7ok4uw	895	12	Kunitz	Kunitz	NNP
cord-001835-0s7ok4uw	895	13	family	family	NN
cord-001835-0s7ok4uw	895	14	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	895	15	at	at	IN
cord-001835-0s7ok4uw	895	16	accelerated	accelerated	JJ
cord-001835-0s7ok4uw	895	17	rates	rate	NNS
cord-001835-0s7ok4uw	895	18	;	;	:
cord-001835-0s7ok4uw	895	19	this	this	DT
cord-001835-0s7ok4uw	895	20	is	be	VBZ
cord-001835-0s7ok4uw	895	21	especially	especially	RB
cord-001835-0s7ok4uw	895	22	true	true	JJ
cord-001835-0s7ok4uw	895	23	of	of	IN
cord-001835-0s7ok4uw	895	24	human	human	JJ
cord-001835-0s7ok4uw	895	25	Kunitz	Kunitz	NNP
cord-001835-0s7ok4uw	895	26	domain	domain	NN
cord-001835-0s7ok4uw	895	27	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	895	28	.	.	.
cord-001835-0s7ok4uw	896	1	Amyloid	amyloid	NN
cord-001835-0s7ok4uw	896	2	precursor	precursor	NN
cord-001835-0s7ok4uw	896	3	protein	protein	NN
cord-001835-0s7ok4uw	896	4	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	896	5	(	(	-LRB-
cord-001835-0s7ok4uw	896	6	APPI	APPI	NNP
cord-001835-0s7ok4uw	896	7	)	)	-RRB-
cord-001835-0s7ok4uw	896	8	and	and	CC
cord-001835-0s7ok4uw	896	9	amyloid	amyloid	NN
cord-001835-0s7ok4uw	896	10	precursor	precursor	NN
cord-001835-0s7ok4uw	896	11	like	like	IN
cord-001835-0s7ok4uw	896	12	protein-2	protein-2	NNP
cord-001835-0s7ok4uw	896	13	(	(	-LRB-
cord-001835-0s7ok4uw	896	14	APLP2	APLP2	NNP
cord-001835-0s7ok4uw	896	15	)	)	-RRB-
cord-001835-0s7ok4uw	896	16	,	,	,
cord-001835-0s7ok4uw	896	17	two	two	CD
cord-001835-0s7ok4uw	896	18	human	human	JJ
cord-001835-0s7ok4uw	896	19	Kunitz	Kunitz	NNP
cord-001835-0s7ok4uw	896	20	domain	domain	NN
cord-001835-0s7ok4uw	896	21	family	family	NN
cord-001835-0s7ok4uw	896	22	members	member	NNS
cord-001835-0s7ok4uw	896	23	,	,	,
cord-001835-0s7ok4uw	896	24	are	be	VBP
cord-001835-0s7ok4uw	896	25	hydrolyzed	hydrolyze	VBN
cord-001835-0s7ok4uw	896	26	by	by	IN
cord-001835-0s7ok4uw	896	27	mesotrypsin	mesotrypsin	NNP
cord-001835-0s7ok4uw	896	28	several	several	JJ
cord-001835-0s7ok4uw	896	29	hundred	hundred	CD
cord-001835-0s7ok4uw	896	30	times	time	NNS
cord-001835-0s7ok4uw	896	31	faster	fast	RBR
cord-001835-0s7ok4uw	896	32	than	than	IN
cord-001835-0s7ok4uw	896	33	BPTI	BPTI	NNP
cord-001835-0s7ok4uw	896	34	.	.	.
cord-001835-0s7ok4uw	897	1	Here	here	RB
cord-001835-0s7ok4uw	897	2	,	,	,
cord-001835-0s7ok4uw	897	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	897	4	present	present	VBP
cord-001835-0s7ok4uw	897	5	a	a	DT
cord-001835-0s7ok4uw	897	6	new	new	JJ
cord-001835-0s7ok4uw	897	7	,	,	,
cord-001835-0s7ok4uw	897	8	unpublished	unpublished	JJ
cord-001835-0s7ok4uw	897	9	crystal	crystal	NN
cord-001835-0s7ok4uw	897	10	structure	structure	NN
cord-001835-0s7ok4uw	897	11	of	of	IN
cord-001835-0s7ok4uw	897	12	a	a	DT
cord-001835-0s7ok4uw	897	13	cleavage	cleavage	NN
cord-001835-0s7ok4uw	897	14	intermediate	intermediate	JJ
cord-001835-0s7ok4uw	897	15	APLP2	APLP2	NNS
cord-001835-0s7ok4uw	897	16	bound	bind	VBN
cord-001835-0s7ok4uw	897	17	to	to	IN
cord-001835-0s7ok4uw	897	18	mesotrypsin	mesotrypsin	NNP
cord-001835-0s7ok4uw	897	19	,	,	,
cord-001835-0s7ok4uw	897	20	refined	refine	VBN
cord-001835-0s7ok4uw	897	21	to	to	IN
cord-001835-0s7ok4uw	897	22	1.4Å	1.4å	NN
cord-001835-0s7ok4uw	897	23	resolution	resolution	NN
cord-001835-0s7ok4uw	897	24	,	,	,
cord-001835-0s7ok4uw	897	25	revealing	reveal	VBG
cord-001835-0s7ok4uw	897	26	a	a	DT
cord-001835-0s7ok4uw	897	27	dramatic	dramatic	JJ
cord-001835-0s7ok4uw	897	28	substrate	substrate	NN
cord-001835-0s7ok4uw	897	29	conformational	conformational	JJ
cord-001835-0s7ok4uw	897	30	change	change	NN
cord-001835-0s7ok4uw	897	31	we	-PRON-	PRP
cord-001835-0s7ok4uw	897	32	hypothesize	hypothesize	VBP
cord-001835-0s7ok4uw	897	33	to	to	TO
cord-001835-0s7ok4uw	897	34	be	be	VB
cord-001835-0s7ok4uw	897	35	required	require	VBN
cord-001835-0s7ok4uw	897	36	during	during	IN
cord-001835-0s7ok4uw	897	37	cleavage	cleavage	NN
cord-001835-0s7ok4uw	897	38	of	of	IN
cord-001835-0s7ok4uw	897	39	a	a	DT
cord-001835-0s7ok4uw	897	40	Kunitz	Kunitz	NNP
cord-001835-0s7ok4uw	897	41	domain	domain	NN
cord-001835-0s7ok4uw	897	42	.	.	.
cord-001835-0s7ok4uw	898	1	Using	use	VBG
cord-001835-0s7ok4uw	898	2	this	this	DT
cord-001835-0s7ok4uw	898	3	structure	structure	NN
cord-001835-0s7ok4uw	898	4	along	along	IN
cord-001835-0s7ok4uw	898	5	with	with	IN
cord-001835-0s7ok4uw	898	6	published	publish	VBN
cord-001835-0s7ok4uw	898	7	structures	structure	NNS
cord-001835-0s7ok4uw	898	8	of	of	IN
cord-001835-0s7ok4uw	898	9	APPI	APPI	NNP
cord-001835-0s7ok4uw	898	10	and	and	CC
cord-001835-0s7ok4uw	898	11	BPTI	BPTI	NNP
cord-001835-0s7ok4uw	898	12	complexes	complex	NNS
cord-001835-0s7ok4uw	898	13	,	,	,
cord-001835-0s7ok4uw	898	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	898	15	have	have	VBP
cord-001835-0s7ok4uw	898	16	modeled	model	VBN
cord-001835-0s7ok4uw	898	17	acyl	acyl	NN
cord-001835-0s7ok4uw	898	18	-	-	HYPH
cord-001835-0s7ok4uw	898	19	enzyme	enzyme	NN
cord-001835-0s7ok4uw	898	20	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	898	21	of	of	IN
cord-001835-0s7ok4uw	898	22	mesotrypsin	mesotrypsin	NNP
cord-001835-0s7ok4uw	898	23	,	,	,
cord-001835-0s7ok4uw	898	24	and	and	CC
cord-001835-0s7ok4uw	898	25	we	-PRON-	PRP
cord-001835-0s7ok4uw	898	26	have	have	VBP
cord-001835-0s7ok4uw	898	27	carried	carry	VBN
cord-001835-0s7ok4uw	898	28	out	out	RP
cord-001835-0s7ok4uw	898	29	molecular	molecular	JJ
cord-001835-0s7ok4uw	898	30	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	898	31	simulations	simulation	NNS
cord-001835-0s7ok4uw	898	32	that	that	WDT
cord-001835-0s7ok4uw	898	33	explore	explore	VBP
cord-001835-0s7ok4uw	898	34	the	the	DT
cord-001835-0s7ok4uw	898	35	transition	transition	NN
cord-001835-0s7ok4uw	898	36	of	of	IN
cord-001835-0s7ok4uw	898	37	the	the	DT
cord-001835-0s7ok4uw	898	38	initially	initially	RB
cord-001835-0s7ok4uw	898	39	formed	form	VBN
cord-001835-0s7ok4uw	898	40	native	native	JJ
cord-001835-0s7ok4uw	898	41	-	-	HYPH
cord-001835-0s7ok4uw	898	42	like	like	JJ
cord-001835-0s7ok4uw	898	43	acyl	acyl	NN
cord-001835-0s7ok4uw	898	44	-	-	HYPH
cord-001835-0s7ok4uw	898	45	enzyme	enzyme	NN
cord-001835-0s7ok4uw	898	46	through	through	IN
cord-001835-0s7ok4uw	898	47	the	the	DT
cord-001835-0s7ok4uw	898	48	conformational	conformational	JJ
cord-001835-0s7ok4uw	898	49	transformation	transformation	NN
cord-001835-0s7ok4uw	898	50	that	that	WDT
cord-001835-0s7ok4uw	898	51	allows	allow	VBZ
cord-001835-0s7ok4uw	898	52	the	the	DT
cord-001835-0s7ok4uw	898	53	progression	progression	NN
cord-001835-0s7ok4uw	898	54	of	of	IN
cord-001835-0s7ok4uw	898	55	the	the	DT
cord-001835-0s7ok4uw	898	56	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	898	57	reaction	reaction	NN
cord-001835-0s7ok4uw	898	58	.	.	.
cord-001835-0s7ok4uw	899	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	899	2	further	further	RB
cord-001835-0s7ok4uw	899	3	identify	identify	VBP
cord-001835-0s7ok4uw	899	4	a	a	DT
cord-001835-0s7ok4uw	899	5	specific	specific	JJ
cord-001835-0s7ok4uw	899	6	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	899	7	bond	bond	NN
cord-001835-0s7ok4uw	899	8	,	,	,
cord-001835-0s7ok4uw	899	9	present	present	JJ
cord-001835-0s7ok4uw	899	10	in	in	IN
cord-001835-0s7ok4uw	899	11	BPTI	BPTI	NNP
cord-001835-0s7ok4uw	899	12	but	but	CC
cord-001835-0s7ok4uw	899	13	not	not	RB
cord-001835-0s7ok4uw	899	14	APPI	APPI	NNP
cord-001835-0s7ok4uw	899	15	,	,	,
cord-001835-0s7ok4uw	899	16	which	which	WDT
cord-001835-0s7ok4uw	899	17	forms	form	VBZ
cord-001835-0s7ok4uw	899	18	a	a	DT
cord-001835-0s7ok4uw	899	19	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	899	20	feature	feature	NN
cord-001835-0s7ok4uw	899	21	of	of	IN
cord-001835-0s7ok4uw	899	22	the	the	DT
cord-001835-0s7ok4uw	899	23	BPTI	BPTI	NNP
cord-001835-0s7ok4uw	899	24	scaffold	scaffold	NN
cord-001835-0s7ok4uw	899	25	.	.	.
cord-001835-0s7ok4uw	900	1	Using	use	VBG
cord-001835-0s7ok4uw	900	2	site	site	NN
cord-001835-0s7ok4uw	900	3	directed	direct	VBN
cord-001835-0s7ok4uw	900	4	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	900	5	,	,	,
cord-001835-0s7ok4uw	900	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	900	7	probe	probe	VBP
cord-001835-0s7ok4uw	900	8	the	the	DT
cord-001835-0s7ok4uw	900	9	contribution	contribution	NN
cord-001835-0s7ok4uw	900	10	of	of	IN
cord-001835-0s7ok4uw	900	11	this	this	DT
cord-001835-0s7ok4uw	900	12	bond	bond	NN
cord-001835-0s7ok4uw	900	13	to	to	IN
cord-001835-0s7ok4uw	900	14	the	the	DT
cord-001835-0s7ok4uw	900	15	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	900	16	stability	stability	NN
cord-001835-0s7ok4uw	900	17	of	of	IN
cord-001835-0s7ok4uw	900	18	BPTI	BPTI	NNP
cord-001835-0s7ok4uw	900	19	.	.	.
cord-001835-0s7ok4uw	901	1	Collectively	collectively	RB
cord-001835-0s7ok4uw	901	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	901	3	data	datum	NNS
cord-001835-0s7ok4uw	901	4	for	for	IN
cord-001835-0s7ok4uw	901	5	these	these	DT
cord-001835-0s7ok4uw	901	6	highly	highly	RB
cord-001835-0s7ok4uw	901	7	structured	structured	JJ
cord-001835-0s7ok4uw	901	8	substrates	substrate	NNS
cord-001835-0s7ok4uw	901	9	show	show	VBP
cord-001835-0s7ok4uw	901	10	that	that	IN
cord-001835-0s7ok4uw	901	11	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	901	12	rates	rate	NNS
cord-001835-0s7ok4uw	901	13	are	be	VBP
cord-001835-0s7ok4uw	901	14	limited	limit	VBN
cord-001835-0s7ok4uw	901	15	by	by	IN
cord-001835-0s7ok4uw	901	16	a	a	DT
cord-001835-0s7ok4uw	901	17	necessary	necessary	JJ
cord-001835-0s7ok4uw	901	18	conformational	conformational	JJ
cord-001835-0s7ok4uw	901	19	change	change	NN
cord-001835-0s7ok4uw	901	20	in	in	IN
cord-001835-0s7ok4uw	901	21	the	the	DT
cord-001835-0s7ok4uw	901	22	substrate	substrate	NN
cord-001835-0s7ok4uw	901	23	as	as	IN
cord-001835-0s7ok4uw	901	24	the	the	DT
cord-001835-0s7ok4uw	901	25	reaction	reaction	NN
cord-001835-0s7ok4uw	901	26	progresses	progress	VBZ
cord-001835-0s7ok4uw	901	27	.	.	.
cord-001835-0s7ok4uw	902	1	Rigid	rigid	JJ
cord-001835-0s7ok4uw	902	2	substrates	substrate	NNS
cord-001835-0s7ok4uw	902	3	possessing	possess	VBG
cord-001835-0s7ok4uw	902	4	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	902	5	features	feature	NNS
cord-001835-0s7ok4uw	902	6	that	that	WDT
cord-001835-0s7ok4uw	902	7	render	render	VBP
cord-001835-0s7ok4uw	902	8	them	-PRON-	PRP
cord-001835-0s7ok4uw	902	9	highly	highly	RB
cord-001835-0s7ok4uw	902	10	resistant	resistant	JJ
cord-001835-0s7ok4uw	902	11	to	to	IN
cord-001835-0s7ok4uw	902	12	this	this	DT
cord-001835-0s7ok4uw	902	13	conformational	conformational	JJ
cord-001835-0s7ok4uw	902	14	change	change	NN
cord-001835-0s7ok4uw	902	15	are	be	VBP
cord-001835-0s7ok4uw	902	16	proteolyzed	proteolyze	VBN
cord-001835-0s7ok4uw	902	17	more	more	RBR
cord-001835-0s7ok4uw	902	18	slowly	slowly	RB
cord-001835-0s7ok4uw	902	19	than	than	IN
cord-001835-0s7ok4uw	902	20	more	more	RBR
cord-001835-0s7ok4uw	902	21	flexible	flexible	JJ
cord-001835-0s7ok4uw	902	22	substrates	substrate	NNS
cord-001835-0s7ok4uw	902	23	of	of	IN
cord-001835-0s7ok4uw	902	24	similar	similar	JJ
cord-001835-0s7ok4uw	902	25	structure	structure	NN
cord-001835-0s7ok4uw	902	26	.	.	.
cord-001835-0s7ok4uw	903	1	LPMOs	lpmo	NNS
cord-001835-0s7ok4uw	903	2	are	be	VBP
cord-001835-0s7ok4uw	903	3	copper	copper	NN
cord-001835-0s7ok4uw	903	4	metalloenzymes	metalloenzyme	NNS
cord-001835-0s7ok4uw	903	5	that	that	WDT
cord-001835-0s7ok4uw	903	6	carry	carry	VBP
cord-001835-0s7ok4uw	903	7	out	out	RP
cord-001835-0s7ok4uw	903	8	the	the	DT
cord-001835-0s7ok4uw	903	9	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	903	10	cleavage	cleavage	NN
cord-001835-0s7ok4uw	903	11	of	of	IN
cord-001835-0s7ok4uw	903	12	the	the	DT
cord-001835-0s7ok4uw	903	13	b-1,4-glycosidic	b-1,4-glycosidic	NNP
cord-001835-0s7ok4uw	903	14	bond	bond	NN
cord-001835-0s7ok4uw	903	15	,	,	,
cord-001835-0s7ok4uw	903	16	generating	generate	VBG
cord-001835-0s7ok4uw	903	17	new	new	JJ
cord-001835-0s7ok4uw	903	18	chain	chain	NN
cord-001835-0s7ok4uw	903	19	ends	end	VBZ
cord-001835-0s7ok4uw	903	20	that	that	WDT
cord-001835-0s7ok4uw	903	21	can	can	MD
cord-001835-0s7ok4uw	903	22	subsequently	subsequently	RB
cord-001835-0s7ok4uw	903	23	be	be	VB
cord-001835-0s7ok4uw	903	24	processed	process	VBN
cord-001835-0s7ok4uw	903	25	by	by	IN
cord-001835-0s7ok4uw	903	26	cellulases	cellulases	NNP
cord-001835-0s7ok4uw	903	27	,	,	,
cord-001835-0s7ok4uw	903	28	boosting	boost	VBG
cord-001835-0s7ok4uw	903	29	the	the	DT
cord-001835-0s7ok4uw	903	30	cellulose	cellulose	NN
cord-001835-0s7ok4uw	903	31	degradation	degradation	NN
cord-001835-0s7ok4uw	903	32	.	.	.
cord-001835-0s7ok4uw	904	1	LPMOs	lpmo	NNS
cord-001835-0s7ok4uw	904	2	have	have	VBP
cord-001835-0s7ok4uw	904	3	a	a	DT
cord-001835-0s7ok4uw	904	4	b	b	NN
cord-001835-0s7ok4uw	904	5	-	-	HYPH
cord-001835-0s7ok4uw	904	6	sandwich	sandwich	NN
cord-001835-0s7ok4uw	904	7	conformation	conformation	NN
cord-001835-0s7ok4uw	904	8	with	with	IN
cord-001835-0s7ok4uw	904	9	a	a	DT
cord-001835-0s7ok4uw	904	10	flat	flat	JJ
cord-001835-0s7ok4uw	904	11	binding	binding	NN
cord-001835-0s7ok4uw	904	12	surface	surface	NN
cord-001835-0s7ok4uw	904	13	,	,	,
cord-001835-0s7ok4uw	904	14	allowing	allow	VBG
cord-001835-0s7ok4uw	904	15	for	for	IN
cord-001835-0s7ok4uw	904	16	the	the	DT
cord-001835-0s7ok4uw	904	17	enzyme	enzyme	NN
cord-001835-0s7ok4uw	904	18	to	to	TO
cord-001835-0s7ok4uw	904	19	bind	bind	VB
cord-001835-0s7ok4uw	904	20	to	to	IN
cord-001835-0s7ok4uw	904	21	crystalline	crystalline	JJ
cord-001835-0s7ok4uw	904	22	cellulose	cellulose	NN
cord-001835-0s7ok4uw	904	23	.	.	.
cord-001835-0s7ok4uw	905	1	The	the	DT
cord-001835-0s7ok4uw	905	2	Cu21	Cu21	NNP
cord-001835-0s7ok4uw	905	3	ion	ion	NN
cord-001835-0s7ok4uw	905	4	,	,	,
cord-001835-0s7ok4uw	905	5	required	require	VBN
cord-001835-0s7ok4uw	905	6	for	for	IN
cord-001835-0s7ok4uw	905	7	activity	activity	NN
cord-001835-0s7ok4uw	905	8	,	,	,
cord-001835-0s7ok4uw	905	9	is	be	VBZ
cord-001835-0s7ok4uw	905	10	located	locate	VBN
cord-001835-0s7ok4uw	905	11	in	in	IN
cord-001835-0s7ok4uw	905	12	a	a	DT
cord-001835-0s7ok4uw	905	13	so	so	RB
cord-001835-0s7ok4uw	905	14	-	-	HYPH
cord-001835-0s7ok4uw	905	15	called	call	VBN
cord-001835-0s7ok4uw	905	16	"	"	``
cord-001835-0s7ok4uw	905	17	histidine	histidine	NN
cord-001835-0s7ok4uw	905	18	brace	brace	NN
cord-001835-0s7ok4uw	905	19	"	"	''
cord-001835-0s7ok4uw	905	20	,	,	,
cord-001835-0s7ok4uw	905	21	in	in	IN
cord-001835-0s7ok4uw	905	22	which	which	WDT
cord-001835-0s7ok4uw	905	23	the	the	DT
cord-001835-0s7ok4uw	905	24	N	n	CD
cord-001835-0s7ok4uw	905	25	-	-	HYPH
cord-001835-0s7ok4uw	905	26	terminal	terminal	NN
cord-001835-0s7ok4uw	905	27	histidine	histidine	NN
cord-001835-0s7ok4uw	905	28	is	be	VBZ
cord-001835-0s7ok4uw	905	29	highly	highly	RB
cord-001835-0s7ok4uw	905	30	conserved	conserve	VBN
cord-001835-0s7ok4uw	905	31	.	.	.
cord-001835-0s7ok4uw	906	1	REGIOSELECTIVITY	REGIOSELECTIVITY	NNP
cord-001835-0s7ok4uw	907	1	According	accord	VBG
cord-001835-0s7ok4uw	907	2	to	to	IN
cord-001835-0s7ok4uw	907	3	the	the	DT
cord-001835-0s7ok4uw	907	4	carbon	carbon	NN
cord-001835-0s7ok4uw	907	5	atom	atom	NN
cord-001835-0s7ok4uw	907	6	being	be	VBG
cord-001835-0s7ok4uw	907	7	oxidized	oxidize	VBN
cord-001835-0s7ok4uw	907	8	,	,	,
cord-001835-0s7ok4uw	907	9	3	3	CD
cord-001835-0s7ok4uw	907	10	LPMO	LPMO	NNP
cord-001835-0s7ok4uw	907	11	types	type	NNS
cord-001835-0s7ok4uw	907	12	are	be	VBP
cord-001835-0s7ok4uw	907	13	identified	identify	VBN
cord-001835-0s7ok4uw	907	14	:	:	:
cord-001835-0s7ok4uw	907	15	type	type	NN
cord-001835-0s7ok4uw	907	16	1	1	CD
cord-001835-0s7ok4uw	907	17	and	and	CC
cord-001835-0s7ok4uw	907	18	type	type	NN
cord-001835-0s7ok4uw	907	19	2	2	CD
cord-001835-0s7ok4uw	907	20	oxidizing	oxidize	VBG
cord-001835-0s7ok4uw	907	21	at	at	IN
cord-001835-0s7ok4uw	907	22	the	the	DT
cord-001835-0s7ok4uw	907	23	C1	C1	NNP
cord-001835-0s7ok4uw	907	24	and	and	CC
cord-001835-0s7ok4uw	907	25	the	the	DT
cord-001835-0s7ok4uw	907	26	C4	c4	NN
cord-001835-0s7ok4uw	907	27	respectively	respectively	RB
cord-001835-0s7ok4uw	907	28	,	,	,
cord-001835-0s7ok4uw	907	29	type	type	NN
cord-001835-0s7ok4uw	907	30	3	3	CD
cord-001835-0s7ok4uw	907	31	LPMOs	lpmo	NNS
cord-001835-0s7ok4uw	907	32	oxidizing	oxidize	VBG
cord-001835-0s7ok4uw	907	33	both	both	CC
cord-001835-0s7ok4uw	907	34	the	the	DT
cord-001835-0s7ok4uw	907	35	C1	c1	NN
cord-001835-0s7ok4uw	907	36	and	and	CC
cord-001835-0s7ok4uw	907	37	the	the	DT
cord-001835-0s7ok4uw	907	38	C4	c4	NN
cord-001835-0s7ok4uw	908	1	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	908	2	to	to	IN
cord-001835-0s7ok4uw	908	3	the	the	DT
cord-001835-0s7ok4uw	908	4	glycosidic	glycosidic	JJ
cord-001835-0s7ok4uw	908	5	linkage	linkage	NN
cord-001835-0s7ok4uw	908	6	.	.	.
cord-001835-0s7ok4uw	909	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	909	2	were	be	VBD
cord-001835-0s7ok4uw	909	3	able	able	JJ
cord-001835-0s7ok4uw	909	4	to	to	TO
cord-001835-0s7ok4uw	909	5	express	express	VB
cord-001835-0s7ok4uw	909	6	a	a	DT
cord-001835-0s7ok4uw	909	7	type-1	type-1	NN
cord-001835-0s7ok4uw	909	8	LPMO	LPMO	NNP
cord-001835-0s7ok4uw	910	1	(	(	-LRB-
cord-001835-0s7ok4uw	910	2	Phanerochaete	Phanerochaete	NNP
cord-001835-0s7ok4uw	910	3	chrysosporium	chrysosporium	NN
cord-001835-0s7ok4uw	910	4	GH61D	GH61D	NNP
cord-001835-0s7ok4uw	910	5	)	)	-RRB-
cord-001835-0s7ok4uw	911	1	and	and	CC
cord-001835-0s7ok4uw	911	2	a	a	DT
cord-001835-0s7ok4uw	911	3	type-3	type-3	NNP
cord-001835-0s7ok4uw	911	4	LPMO	LPMO	NNP
cord-001835-0s7ok4uw	912	1	(	(	-LRB-
cord-001835-0s7ok4uw	912	2	Trichoderma	Trichoderma	NNP
cord-001835-0s7ok4uw	912	3	reesei	reesei	NN
cord-001835-0s7ok4uw	912	4	Cel61A	Cel61A	NNP
cord-001835-0s7ok4uw	912	5	)	)	-RRB-
cord-001835-0s7ok4uw	912	6	in	in	IN
cord-001835-0s7ok4uw	912	7	P.	P.	NNP
cord-001835-0s7ok4uw	912	8	pastoris	pastoris	NN
cord-001835-0s7ok4uw	912	9	.	.	.
cord-001835-0s7ok4uw	913	1	This	this	DT
cord-001835-0s7ok4uw	913	2	has	have	VBZ
cord-001835-0s7ok4uw	913	3	proven	prove	VBN
cord-001835-0s7ok4uw	913	4	to	to	TO
cord-001835-0s7ok4uw	913	5	be	be	VB
cord-001835-0s7ok4uw	913	6	very	very	RB
cord-001835-0s7ok4uw	913	7	challenging	challenging	JJ
cord-001835-0s7ok4uw	913	8	,	,	,
cord-001835-0s7ok4uw	913	9	as	as	IN
cord-001835-0s7ok4uw	913	10	LPMO	LPMO	NNP
cord-001835-0s7ok4uw	913	11	activity	activity	NN
cord-001835-0s7ok4uw	913	12	requires	require	VBZ
cord-001835-0s7ok4uw	913	13	a	a	DT
cord-001835-0s7ok4uw	913	14	perfect	perfect	JJ
cord-001835-0s7ok4uw	913	15	cleavage	cleavage	NN
cord-001835-0s7ok4uw	913	16	of	of	IN
cord-001835-0s7ok4uw	913	17	the	the	DT
cord-001835-0s7ok4uw	913	18	signal	signal	JJ
cord-001835-0s7ok4uw	913	19	sequence	sequence	NN
cord-001835-0s7ok4uw	913	20	.	.	.
cord-001835-0s7ok4uw	914	1	After	after	IN
cord-001835-0s7ok4uw	914	2	activity	activity	NN
cord-001835-0s7ok4uw	914	3	assays	assay	NNS
cord-001835-0s7ok4uw	914	4	on	on	IN
cord-001835-0s7ok4uw	914	5	PASC	PASC	NNP
cord-001835-0s7ok4uw	914	6	,	,	,
cord-001835-0s7ok4uw	914	7	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	914	8	HPAEC	HPAEC	NNP
cord-001835-0s7ok4uw	914	9	-	-	HYPH
cord-001835-0s7ok4uw	914	10	PAD	pad	NN
cord-001835-0s7ok4uw	914	11	traces	trace	NNS
cord-001835-0s7ok4uw	914	12	were	be	VBD
cord-001835-0s7ok4uw	914	13	obtained	obtain	VBN
cord-001835-0s7ok4uw	914	14	which	which	WDT
cord-001835-0s7ok4uw	914	15	will	will	MD
cord-001835-0s7ok4uw	914	16	serve	serve	VB
cord-001835-0s7ok4uw	914	17	as	as	IN
cord-001835-0s7ok4uw	914	18	a	a	DT
cord-001835-0s7ok4uw	914	19	reference	reference	NN
cord-001835-0s7ok4uw	914	20	for	for	IN
cord-001835-0s7ok4uw	914	21	engineering	engineering	NN
cord-001835-0s7ok4uw	914	22	experiments	experiment	NNS
cord-001835-0s7ok4uw	914	23	.	.	.
cord-001835-0s7ok4uw	915	1	ENZYME	enzyme	NN
cord-001835-0s7ok4uw	915	2	ENGINEERING	engineering	NN
cord-001835-0s7ok4uw	916	1	Using	use	VBG
cord-001835-0s7ok4uw	916	2	the	the	DT
cord-001835-0s7ok4uw	916	3	3DM	3DM	NNP
cord-001835-0s7ok4uw	916	4	database	database	NN
cord-001835-0s7ok4uw	916	5	,	,	,
cord-001835-0s7ok4uw	916	6	a	a	DT
cord-001835-0s7ok4uw	916	7	structure	structure	NN
cord-001835-0s7ok4uw	916	8	based	base	VBN
cord-001835-0s7ok4uw	916	9	multiple	multiple	JJ
cord-001835-0s7ok4uw	916	10	sequence	sequence	NN
cord-001835-0s7ok4uw	916	11	alignment	alignment	NN
cord-001835-0s7ok4uw	916	12	tool	tool	NN
cord-001835-0s7ok4uw	916	13	,	,	,
cord-001835-0s7ok4uw	916	14	it	-PRON-	PRP
cord-001835-0s7ok4uw	916	15	is	be	VBZ
cord-001835-0s7ok4uw	916	16	possible	possible	JJ
cord-001835-0s7ok4uw	916	17	to	to	TO
cord-001835-0s7ok4uw	916	18	identify	identify	VB
cord-001835-0s7ok4uw	916	19	residues	residue	NNS
cord-001835-0s7ok4uw	916	20	specifically	specifically	RB
cord-001835-0s7ok4uw	916	21	conserved	conserve	VBN
cord-001835-0s7ok4uw	916	22	in	in	IN
cord-001835-0s7ok4uw	916	23	subsets	subset	NNS
cord-001835-0s7ok4uw	916	24	of	of	IN
cord-001835-0s7ok4uw	916	25	protein	protein	NN
cord-001835-0s7ok4uw	916	26	sequences	sequence	NNS
cord-001835-0s7ok4uw	916	27	.	.	.
cord-001835-0s7ok4uw	917	1	By	by	IN
cord-001835-0s7ok4uw	917	2	defining	define	VBG
cord-001835-0s7ok4uw	917	3	a	a	DT
cord-001835-0s7ok4uw	917	4	subset	subset	NN
cord-001835-0s7ok4uw	917	5	for	for	IN
cord-001835-0s7ok4uw	917	6	each	each	DT
cord-001835-0s7ok4uw	917	7	LPMO	LPMO	NNP
cord-001835-0s7ok4uw	917	8	type	type	NN
cord-001835-0s7ok4uw	917	9	,	,	,
cord-001835-0s7ok4uw	917	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	917	11	were	be	VBD
cord-001835-0s7ok4uw	917	12	able	able	JJ
cord-001835-0s7ok4uw	917	13	to	to	TO
cord-001835-0s7ok4uw	917	14	identify	identify	VB
cord-001835-0s7ok4uw	917	15	residues	residue	NNS
cord-001835-0s7ok4uw	917	16	contributing	contribute	VBG
cord-001835-0s7ok4uw	917	17	to	to	IN
cord-001835-0s7ok4uw	917	18	regioselectivity	regioselectivity	NN
cord-001835-0s7ok4uw	917	19	.	.	.
cord-001835-0s7ok4uw	918	1	These	these	DT
cord-001835-0s7ok4uw	918	2	positions	position	NNS
cord-001835-0s7ok4uw	918	3	are	be	VBP
cord-001835-0s7ok4uw	918	4	now	now	RB
cord-001835-0s7ok4uw	918	5	being	be	VBG
cord-001835-0s7ok4uw	918	6	rationally	rationally	RB
cord-001835-0s7ok4uw	918	7	engineered	engineer	VBN
cord-001835-0s7ok4uw	918	8	in	in	IN
cord-001835-0s7ok4uw	918	9	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	918	10	rounds	round	NNS
cord-001835-0s7ok4uw	918	11	of	of	IN
cord-001835-0s7ok4uw	918	12	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	918	13	,	,	,
cord-001835-0s7ok4uw	918	14	using	use	VBG
cord-001835-0s7ok4uw	918	15	TrCel61A	trcel61a	CD
cord-001835-0s7ok4uw	918	16	as	as	IN
cord-001835-0s7ok4uw	918	17	a	a	DT
cord-001835-0s7ok4uw	918	18	template	template	NN
cord-001835-0s7ok4uw	918	19	.	.	.
cord-001835-0s7ok4uw	919	1	The	the	DT
cord-001835-0s7ok4uw	919	2	effect	effect	NN
cord-001835-0s7ok4uw	919	3	of	of	IN
cord-001835-0s7ok4uw	919	4	the	the	DT
cord-001835-0s7ok4uw	919	5	mutations	mutation	NNS
cord-001835-0s7ok4uw	919	6	will	will	MD
cord-001835-0s7ok4uw	919	7	be	be	VB
cord-001835-0s7ok4uw	919	8	determined	determine	VBN
cord-001835-0s7ok4uw	919	9	by	by	IN
cord-001835-0s7ok4uw	919	10	analyzing	analyze	VBG
cord-001835-0s7ok4uw	919	11	the	the	DT
cord-001835-0s7ok4uw	919	12	HPAEC	HPAEC	NNP
cord-001835-0s7ok4uw	919	13	-	-	HYPH
cord-001835-0s7ok4uw	919	14	PAD	pad	NN
cord-001835-0s7ok4uw	919	15	trace	trace	NN
cord-001835-0s7ok4uw	919	16	released	release	VBN
cord-001835-0s7ok4uw	919	17	from	from	IN
cord-001835-0s7ok4uw	919	18	PASC	PASC	NNP
cord-001835-0s7ok4uw	919	19	.	.	.
cord-001835-0s7ok4uw	920	1	The	the	DT
cord-001835-0s7ok4uw	920	2	main	main	JJ
cord-001835-0s7ok4uw	920	3	goal	goal	NN
cord-001835-0s7ok4uw	920	4	is	be	VBZ
cord-001835-0s7ok4uw	920	5	to	to	TO
cord-001835-0s7ok4uw	920	6	investigate	investigate	VB
cord-001835-0s7ok4uw	920	7	the	the	DT
cord-001835-0s7ok4uw	920	8	possibility	possibility	NN
cord-001835-0s7ok4uw	920	9	of	of	IN
cord-001835-0s7ok4uw	920	10	deleting	delete	VBG
cord-001835-0s7ok4uw	920	11	the	the	DT
cord-001835-0s7ok4uw	920	12	C4	c4	NN
cord-001835-0s7ok4uw	920	13	specificity	specificity	NN
cord-001835-0s7ok4uw	920	14	in	in	IN
cord-001835-0s7ok4uw	920	15	a	a	DT
cord-001835-0s7ok4uw	920	16	type	type	NN
cord-001835-0s7ok4uw	920	17	3	3	CD
cord-001835-0s7ok4uw	920	18	LPMO	LPMO	NNP
cord-001835-0s7ok4uw	920	19	.	.	.
cord-001835-0s7ok4uw	921	1	Folding	folding	NN
cord-001835-0s7ok4uw	921	2	topology	topology	NN
cord-001835-0s7ok4uw	921	3	determines	determine	VBZ
cord-001835-0s7ok4uw	921	4	substrate	substrate	NN
cord-001835-0s7ok4uw	921	5	binding	bind	VBG
cord-001835-0s7ok4uw	921	6	order	order	NN
cord-001835-0s7ok4uw	921	7	in	in	IN
cord-001835-0s7ok4uw	921	8	the	the	DT
cord-001835-0s7ok4uw	921	9	ribokinase	ribokinase	NN
cord-001835-0s7ok4uw	921	10	superfamily	superfamily	NN
cord-001835-0s7ok4uw	921	11	Alejandra	Alejandra	NNP
cord-001835-0s7ok4uw	921	12	Herrera	Herrera	NNP
cord-001835-0s7ok4uw	921	13	-	-	HYPH
cord-001835-0s7ok4uw	921	14	Morand	Morand	NNP
cord-001835-0s7ok4uw	922	1	e	e	LS
cord-001835-0s7ok4uw	922	2	1	1	CD
cord-001835-0s7ok4uw	922	3	,	,	,
cord-001835-0s7ok4uw	922	4	Victor	Victor	NNP
cord-001835-0s7ok4uw	922	5	Castro	Castro	NNP
cord-001835-0s7ok4uw	922	6	-	-	HYPH
cord-001835-0s7ok4uw	922	7	Fern	Fern	NNP
cord-001835-0s7ok4uw	922	8	andez	andez	VBD
cord-001835-0s7ok4uw	922	9	1	1	CD
cord-001835-0s7ok4uw	922	10	,	,	,
cord-001835-0s7ok4uw	922	11	Madrid	Madrid	NNP
cord-001835-0s7ok4uw	922	12	,	,	,
cord-001835-0s7ok4uw	922	13	España	España	NNP
cord-001835-0s7ok4uw	922	14	Ribokinase	Ribokinase	NNP
cord-001835-0s7ok4uw	922	15	superfamily	superfamily	NN
cord-001835-0s7ok4uw	922	16	comprises	comprise	VBZ
cord-001835-0s7ok4uw	922	17	three	three	CD
cord-001835-0s7ok4uw	922	18	enzyme	enzyme	NN
cord-001835-0s7ok4uw	922	19	families	family	NNS
cord-001835-0s7ok4uw	922	20	:	:	:
cord-001835-0s7ok4uw	922	21	the	the	DT
cord-001835-0s7ok4uw	922	22	ADP	ADP	NNP
cord-001835-0s7ok4uw	922	23	-	-	HYPH
cord-001835-0s7ok4uw	922	24	dependent	dependent	JJ
cord-001835-0s7ok4uw	922	25	sugar	sugar	NN
cord-001835-0s7ok4uw	922	26	kinases	kinase	NNS
cord-001835-0s7ok4uw	922	27	family	family	NN
cord-001835-0s7ok4uw	922	28	,	,	,
cord-001835-0s7ok4uw	922	29	the	the	DT
cord-001835-0s7ok4uw	922	30	ATPdependent	ATPdependent	NNP
cord-001835-0s7ok4uw	922	31	coenzyme	coenzyme	NN
cord-001835-0s7ok4uw	922	32	kinases	kinases	VBP
cord-001835-0s7ok4uw	922	33	family	family	NN
cord-001835-0s7ok4uw	922	34	and	and	CC
cord-001835-0s7ok4uw	922	35	the	the	DT
cord-001835-0s7ok4uw	922	36	ATP	ATP	NNP
cord-001835-0s7ok4uw	922	37	-	-	HYPH
cord-001835-0s7ok4uw	922	38	dependent	dependent	JJ
cord-001835-0s7ok4uw	922	39	sugar	sugar	NN
cord-001835-0s7ok4uw	922	40	kinases	kinase	NNS
cord-001835-0s7ok4uw	922	41	family	family	NN
cord-001835-0s7ok4uw	922	42	.	.	.
cord-001835-0s7ok4uw	923	1	In	in	IN
cord-001835-0s7ok4uw	923	2	all	all	PDT
cord-001835-0s7ok4uw	923	3	these	these	DT
cord-001835-0s7ok4uw	923	4	families	family	NNS
cord-001835-0s7ok4uw	923	5	there	there	EX
cord-001835-0s7ok4uw	923	6	is	be	VBZ
cord-001835-0s7ok4uw	923	7	a	a	DT
cord-001835-0s7ok4uw	923	8	large	large	JJ
cord-001835-0s7ok4uw	923	9	domain	domain	NN
cord-001835-0s7ok4uw	923	10	composed	compose	VBN
cord-001835-0s7ok4uw	923	11	by	by	IN
cord-001835-0s7ok4uw	923	12	a	a	DT
cord-001835-0s7ok4uw	923	13	Rossmann	Rossmann	NNP
cord-001835-0s7ok4uw	923	14	motif	motif	NN
cord-001835-0s7ok4uw	923	15	but	but	CC
cord-001835-0s7ok4uw	923	16	only	only	RB
cord-001835-0s7ok4uw	923	17	the	the	DT
cord-001835-0s7ok4uw	923	18	ATP	ATP	NNP
cord-001835-0s7ok4uw	923	19	-	-	HYPH
cord-001835-0s7ok4uw	923	20	dependent	dependent	JJ
cord-001835-0s7ok4uw	923	21	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	923	22	have	have	VBP
cord-001835-0s7ok4uw	923	23	a	a	DT
cord-001835-0s7ok4uw	923	24	b	b	NN
cord-001835-0s7ok4uw	923	25	-	-	HYPH
cord-001835-0s7ok4uw	923	26	meander	meander	VB
cord-001835-0s7ok4uw	923	27	motif	motif	NN
cord-001835-0s7ok4uw	923	28	in	in	IN
cord-001835-0s7ok4uw	923	29	the	the	DT
cord-001835-0s7ok4uw	923	30	C	c	NN
cord-001835-0s7ok4uw	923	31	-	-	HYPH
cord-001835-0s7ok4uw	923	32	terminal	terminal	NN
cord-001835-0s7ok4uw	923	33	end	end	NN
cord-001835-0s7ok4uw	923	34	.	.	.
cord-001835-0s7ok4uw	924	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	924	2	,	,	,
cord-001835-0s7ok4uw	924	3	these	these	DT
cord-001835-0s7ok4uw	924	4	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	924	5	display	display	VBP
cord-001835-0s7ok4uw	924	6	an	an	DT
cord-001835-0s7ok4uw	924	7	ordered	order	VBN
cord-001835-0s7ok4uw	924	8	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	924	9	mechanism	mechanism	NN
cord-001835-0s7ok4uw	924	10	where	where	WRB
cord-001835-0s7ok4uw	924	11	the	the	DT
cord-001835-0s7ok4uw	924	12	substrate	substrate	NN
cord-001835-0s7ok4uw	924	13	that	that	WDT
cord-001835-0s7ok4uw	924	14	will	will	MD
cord-001835-0s7ok4uw	924	15	be	be	VB
cord-001835-0s7ok4uw	924	16	phosphorylated	phosphorylate	VBN
cord-001835-0s7ok4uw	924	17	binds	bind	VBZ
cord-001835-0s7ok4uw	924	18	first	first	RB
cord-001835-0s7ok4uw	924	19	to	to	IN
cord-001835-0s7ok4uw	924	20	the	the	DT
cord-001835-0s7ok4uw	924	21	enzyme	enzyme	NN
cord-001835-0s7ok4uw	924	22	.	.	.
cord-001835-0s7ok4uw	925	1	The	the	DT
cord-001835-0s7ok4uw	925	2	ADP	ADP	NNP
cord-001835-0s7ok4uw	925	3	-	-	HYPH
cord-001835-0s7ok4uw	925	4	dependent	dependent	JJ
cord-001835-0s7ok4uw	925	5	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	925	6	present	present	VBP
cord-001835-0s7ok4uw	925	7	a	a	DT
cord-001835-0s7ok4uw	925	8	topological	topological	JJ
cord-001835-0s7ok4uw	925	9	re	re	NN
cord-001835-0s7ok4uw	925	10	-	-	NN
cord-001835-0s7ok4uw	925	11	ordering	ordering	NN
cord-001835-0s7ok4uw	925	12	of	of	IN
cord-001835-0s7ok4uw	925	13	the	the	DT
cord-001835-0s7ok4uw	925	14	secondary	secondary	JJ
cord-001835-0s7ok4uw	925	15	structural	structural	JJ
cord-001835-0s7ok4uw	925	16	elements	element	NNS
cord-001835-0s7ok4uw	925	17	which	which	WDT
cord-001835-0s7ok4uw	925	18	produces	produce	VBZ
cord-001835-0s7ok4uw	925	19	an	an	DT
cord-001835-0s7ok4uw	925	20	equivalent	equivalent	JJ
cord-001835-0s7ok4uw	925	21	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	925	22	structure	structure	NN
cord-001835-0s7ok4uw	925	23	,	,	,
cord-001835-0s7ok4uw	925	24	which	which	WDT
cord-001835-0s7ok4uw	925	25	can	can	MD
cord-001835-0s7ok4uw	925	26	be	be	VB
cord-001835-0s7ok4uw	925	27	thought	think	VBN
cord-001835-0s7ok4uw	925	28	as	as	IN
cord-001835-0s7ok4uw	925	29	a	a	DT
cord-001835-0s7ok4uw	925	30	non	non	JJ
cord-001835-0s7ok4uw	925	31	-	-	JJ
cord-001835-0s7ok4uw	925	32	circular	circular	JJ
cord-001835-0s7ok4uw	925	33	permutation	permutation	NN
cord-001835-0s7ok4uw	925	34	(	(	-LRB-
cord-001835-0s7ok4uw	925	35	NCP	NCP	NNP
cord-001835-0s7ok4uw	925	36	)	)	-RRB-
cord-001835-0s7ok4uw	925	37	of	of	IN
cord-001835-0s7ok4uw	925	38	the	the	DT
cord-001835-0s7ok4uw	925	39	bmeander	bmeander	NNP
cord-001835-0s7ok4uw	925	40	region	region	NN
cord-001835-0s7ok4uw	925	41	.	.	.
cord-001835-0s7ok4uw	926	1	These	these	DT
cord-001835-0s7ok4uw	926	2	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	926	3	also	also	RB
cord-001835-0s7ok4uw	926	4	display	display	VBP
cord-001835-0s7ok4uw	926	5	an	an	DT
cord-001835-0s7ok4uw	926	6	ordered	order	VBN
cord-001835-0s7ok4uw	926	7	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	926	8	mechanism	mechanism	NN
cord-001835-0s7ok4uw	926	9	but	but	CC
cord-001835-0s7ok4uw	926	10	with	with	IN
cord-001835-0s7ok4uw	926	11	an	an	DT
cord-001835-0s7ok4uw	926	12	inversed	inversed	JJ
cord-001835-0s7ok4uw	926	13	order	order	NN
cord-001835-0s7ok4uw	926	14	being	be	VBG
cord-001835-0s7ok4uw	926	15	the	the	DT
cord-001835-0s7ok4uw	926	16	nucleotide	nucleotide	NN
cord-001835-0s7ok4uw	926	17	the	the	DT
cord-001835-0s7ok4uw	926	18	first	first	JJ
cord-001835-0s7ok4uw	926	19	substrate	substrate	NN
cord-001835-0s7ok4uw	926	20	to	to	TO
cord-001835-0s7ok4uw	926	21	bind	bind	VB
cord-001835-0s7ok4uw	926	22	to	to	IN
cord-001835-0s7ok4uw	926	23	the	the	DT
cord-001835-0s7ok4uw	926	24	enzyme	enzyme	NN
cord-001835-0s7ok4uw	926	25	.	.	.
cord-001835-0s7ok4uw	927	1	As	as	IN
cord-001835-0s7ok4uw	927	2	this	this	DT
cord-001835-0s7ok4uw	927	3	b	b	NN
cord-001835-0s7ok4uw	927	4	-	-	HYPH
cord-001835-0s7ok4uw	927	5	meander	meander	NN
cord-001835-0s7ok4uw	927	6	region	region	NN
cord-001835-0s7ok4uw	927	7	of	of	IN
cord-001835-0s7ok4uw	927	8	the	the	DT
cord-001835-0s7ok4uw	927	9	proteins	protein	NNS
cord-001835-0s7ok4uw	927	10	constitutes	constitute	VBZ
cord-001835-0s7ok4uw	927	11	almost	almost	RB
cord-001835-0s7ok4uw	927	12	entirely	entirely	RB
cord-001835-0s7ok4uw	927	13	the	the	DT
cord-001835-0s7ok4uw	927	14	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	927	15	binding	bind	VBG
cord-001835-0s7ok4uw	927	16	site	site	NN
cord-001835-0s7ok4uw	927	17	,	,	,
cord-001835-0s7ok4uw	927	18	and	and	CC
cord-001835-0s7ok4uw	927	19	given	give	VBN
cord-001835-0s7ok4uw	927	20	that	that	IN
cord-001835-0s7ok4uw	927	21	the	the	DT
cord-001835-0s7ok4uw	927	22	permutation	permutation	NN
cord-001835-0s7ok4uw	927	23	is	be	VBZ
cord-001835-0s7ok4uw	927	24	the	the	DT
cord-001835-0s7ok4uw	927	25	major	major	JJ
cord-001835-0s7ok4uw	927	26	structural	structural	JJ
cord-001835-0s7ok4uw	927	27	difference	difference	NN
cord-001835-0s7ok4uw	927	28	between	between	IN
cord-001835-0s7ok4uw	927	29	ADP	ADP	NNP
cord-001835-0s7ok4uw	927	30	and	and	CC
cord-001835-0s7ok4uw	927	31	ATP	ATP	NNP
cord-001835-0s7ok4uw	927	32	-	-	HYPH
cord-001835-0s7ok4uw	927	33	dependent	dependent	JJ
cord-001835-0s7ok4uw	927	34	kinases	kinase	NNS
cord-001835-0s7ok4uw	927	35	,	,	,
cord-001835-0s7ok4uw	927	36	it	-PRON-	PRP
cord-001835-0s7ok4uw	927	37	could	could	MD
cord-001835-0s7ok4uw	927	38	the	the	DT
cord-001835-0s7ok4uw	927	39	responsible	responsible	JJ
cord-001835-0s7ok4uw	927	40	for	for	IN
cord-001835-0s7ok4uw	927	41	the	the	DT
cord-001835-0s7ok4uw	927	42	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	927	43	specificity	specificity	NN
cord-001835-0s7ok4uw	927	44	.	.	.
cord-001835-0s7ok4uw	928	1	To	to	TO
cord-001835-0s7ok4uw	928	2	test	test	VB
cord-001835-0s7ok4uw	928	3	this	this	DT
cord-001835-0s7ok4uw	928	4	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	928	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	928	6	introduce	introduce	VBP
cord-001835-0s7ok4uw	928	7	,	,	,
cord-001835-0s7ok4uw	928	8	by	by	IN
cord-001835-0s7ok4uw	928	9	permutation	permutation	NN
cord-001835-0s7ok4uw	928	10	,	,	,
cord-001835-0s7ok4uw	928	11	an	an	DT
cord-001835-0s7ok4uw	928	12	ATP	ATP	NNP
cord-001835-0s7ok4uw	928	13	-	-	HYPH
cord-001835-0s7ok4uw	928	14	dependent	dependent	JJ
cord-001835-0s7ok4uw	928	15	topology	topology	NN
cord-001835-0s7ok4uw	928	16	in	in	IN
cord-001835-0s7ok4uw	928	17	the	the	DT
cord-001835-0s7ok4uw	928	18	homologous	homologous	JJ
cord-001835-0s7ok4uw	928	19	ADP	ADP	NNP
cord-001835-0s7ok4uw	928	20	-	-	HYPH
cord-001835-0s7ok4uw	928	21	dependent	dependent	JJ
cord-001835-0s7ok4uw	928	22	glucokinase	glucokinase	NN
cord-001835-0s7ok4uw	928	23	from	from	IN
cord-001835-0s7ok4uw	928	24	T.	T.	NNP
cord-001835-0s7ok4uw	928	25	litoralis	litoralis	NNP
cord-001835-0s7ok4uw	928	26	(	(	-LRB-
cord-001835-0s7ok4uw	928	27	perGK	perGK	NNP
cord-001835-0s7ok4uw	928	28	)	)	-RRB-
cord-001835-0s7ok4uw	928	29	.	.	.
cord-001835-0s7ok4uw	929	1	Size	size	NN
cord-001835-0s7ok4uw	929	2	exclusion	exclusion	NN
cord-001835-0s7ok4uw	929	3	chromatography	chromatography	NN
cord-001835-0s7ok4uw	929	4	and	and	CC
cord-001835-0s7ok4uw	929	5	circular	circular	JJ
cord-001835-0s7ok4uw	929	6	dichroism	dichroism	NN
cord-001835-0s7ok4uw	929	7	spectra	spectrum	NNS
cord-001835-0s7ok4uw	929	8	show	show	NN
cord-001835-0s7ok4uw	929	9	that	that	IN
cord-001835-0s7ok4uw	929	10	both	both	CC
cord-001835-0s7ok4uw	929	11	the	the	DT
cord-001835-0s7ok4uw	929	12	wild	wild	JJ
cord-001835-0s7ok4uw	929	13	type	type	NN
cord-001835-0s7ok4uw	929	14	and	and	CC
cord-001835-0s7ok4uw	929	15	the	the	DT
cord-001835-0s7ok4uw	929	16	permutated	permutated	JJ
cord-001835-0s7ok4uw	929	17	enzyme	enzyme	NN
cord-001835-0s7ok4uw	929	18	eluted	elute	VBN
cord-001835-0s7ok4uw	929	19	as	as	IN
cord-001835-0s7ok4uw	929	20	monomers	monomer	NNS
cord-001835-0s7ok4uw	929	21	with	with	IN
cord-001835-0s7ok4uw	929	22	similar	similar	JJ
cord-001835-0s7ok4uw	929	23	hydrodynamic	hydrodynamic	JJ
cord-001835-0s7ok4uw	929	24	behavior	behavior	NN
cord-001835-0s7ok4uw	929	25	,	,	,
cord-001835-0s7ok4uw	929	26	and	and	CC
cord-001835-0s7ok4uw	929	27	have	have	VBP
cord-001835-0s7ok4uw	929	28	the	the	DT
cord-001835-0s7ok4uw	929	29	same	same	JJ
cord-001835-0s7ok4uw	929	30	secondary	secondary	JJ
cord-001835-0s7ok4uw	929	31	structure	structure	NN
cord-001835-0s7ok4uw	929	32	content	content	NN
cord-001835-0s7ok4uw	929	33	.	.	.
cord-001835-0s7ok4uw	930	1	Kinetic	kinetic	JJ
cord-001835-0s7ok4uw	930	2	assays	assay	NNS
cord-001835-0s7ok4uw	930	3	employing	employ	VBG
cord-001835-0s7ok4uw	930	4	ATP	ATP	NNP
cord-001835-0s7ok4uw	930	5	or	or	CC
cord-001835-0s7ok4uw	930	6	ADP	ADP	NNP
cord-001835-0s7ok4uw	930	7	as	as	IN
cord-001835-0s7ok4uw	930	8	substrate	substrate	NN
cord-001835-0s7ok4uw	930	9	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	930	10	that	that	IN
cord-001835-0s7ok4uw	930	11	even	even	RB
cord-001835-0s7ok4uw	930	12	in	in	IN
cord-001835-0s7ok4uw	930	13	the	the	DT
cord-001835-0s7ok4uw	930	14	presence	presence	NN
cord-001835-0s7ok4uw	930	15	of	of	IN
cord-001835-0s7ok4uw	930	16	10	10	CD
cord-001835-0s7ok4uw	930	17	mM	mm	CD
cord-001835-0s7ok4uw	930	18	ATP	ATP	NNP
cord-001835-0s7ok4uw	930	19	,	,	,
cord-001835-0s7ok4uw	930	20	the	the	DT
cord-001835-0s7ok4uw	930	21	perGK	perGK	NNP
cord-001835-0s7ok4uw	930	22	enzyme	enzyme	NN
cord-001835-0s7ok4uw	930	23	is	be	VBZ
cord-001835-0s7ok4uw	930	24	not	not	RB
cord-001835-0s7ok4uw	930	25	able	able	JJ
cord-001835-0s7ok4uw	930	26	to	to	TO
cord-001835-0s7ok4uw	930	27	carry	carry	VB
cord-001835-0s7ok4uw	930	28	out	out	RP
cord-001835-0s7ok4uw	930	29	the	the	DT
cord-001835-0s7ok4uw	930	30	phosphoryl	phosphoryl	NNP
cord-001835-0s7ok4uw	930	31	transfer	transfer	NN
cord-001835-0s7ok4uw	930	32	.	.	.
cord-001835-0s7ok4uw	931	1	To	to	TO
cord-001835-0s7ok4uw	931	2	test	test	VB
cord-001835-0s7ok4uw	931	3	if	if	IN
cord-001835-0s7ok4uw	931	4	the	the	DT
cord-001835-0s7ok4uw	931	5	NCP	NCP	NNP
cord-001835-0s7ok4uw	931	6	has	have	VBZ
cord-001835-0s7ok4uw	931	7	an	an	DT
cord-001835-0s7ok4uw	931	8	impact	impact	NN
cord-001835-0s7ok4uw	931	9	in	in	IN
cord-001835-0s7ok4uw	931	10	the	the	DT
cord-001835-0s7ok4uw	931	11	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	931	12	constants	constant	NNS
cord-001835-0s7ok4uw	931	13	and	and	CC
cord-001835-0s7ok4uw	931	14	substrate	substrate	NN
cord-001835-0s7ok4uw	931	15	binding	bind	VBG
cord-001835-0s7ok4uw	931	16	order	order	NN
cord-001835-0s7ok4uw	931	17	we	-PRON-	PRP
cord-001835-0s7ok4uw	931	18	determine	determine	VBP
cord-001835-0s7ok4uw	931	19	the	the	DT
cord-001835-0s7ok4uw	931	20	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	931	21	mechanism	mechanism	NN
cord-001835-0s7ok4uw	931	22	through	through	IN
cord-001835-0s7ok4uw	931	23	classical	classical	JJ
cord-001835-0s7ok4uw	931	24	protocols	protocol	NNS
cord-001835-0s7ok4uw	931	25	,	,	,
cord-001835-0s7ok4uw	931	26	involving	involve	VBG
cord-001835-0s7ok4uw	931	27	initial	initial	JJ
cord-001835-0s7ok4uw	931	28	velocity	velocity	NN
cord-001835-0s7ok4uw	931	29	studies	study	NNS
cord-001835-0s7ok4uw	931	30	,	,	,
cord-001835-0s7ok4uw	931	31	product	product	NN
cord-001835-0s7ok4uw	931	32	inhibition	inhibition	NN
cord-001835-0s7ok4uw	931	33	and	and	CC
cord-001835-0s7ok4uw	931	34	dead	dead	JJ
cord-001835-0s7ok4uw	931	35	end	end	NN
cord-001835-0s7ok4uw	931	36	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	931	37	.	.	.
cord-001835-0s7ok4uw	932	1	The	the	DT
cord-001835-0s7ok4uw	932	2	results	result	NNS
cord-001835-0s7ok4uw	932	3	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	932	4	that	that	IN
cord-001835-0s7ok4uw	932	5	the	the	DT
cord-001835-0s7ok4uw	932	6	perGK	perGK	NNP
cord-001835-0s7ok4uw	932	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	932	8	presents	present	VBZ
cord-001835-0s7ok4uw	932	9	an	an	DT
cord-001835-0s7ok4uw	932	10	altered	alter	VBN
cord-001835-0s7ok4uw	932	11	substrate	substrate	NN
cord-001835-0s7ok4uw	932	12	binding	bind	VBG
cord-001835-0s7ok4uw	932	13	order	order	NN
cord-001835-0s7ok4uw	932	14	compared	compare	VBN
cord-001835-0s7ok4uw	932	15	to	to	IN
cord-001835-0s7ok4uw	932	16	the	the	DT
cord-001835-0s7ok4uw	932	17	wild	wild	JJ
cord-001835-0s7ok4uw	932	18	type	type	NN
cord-001835-0s7ok4uw	932	19	enzyme	enzyme	NN
cord-001835-0s7ok4uw	932	20	,	,	,
cord-001835-0s7ok4uw	932	21	where	where	WRB
cord-001835-0s7ok4uw	932	22	glucose	glucose	NN
cord-001835-0s7ok4uw	932	23	was	be	VBD
cord-001835-0s7ok4uw	932	24	the	the	DT
cord-001835-0s7ok4uw	932	25	first	first	JJ
cord-001835-0s7ok4uw	932	26	substrate	substrate	NN
cord-001835-0s7ok4uw	932	27	to	to	TO
cord-001835-0s7ok4uw	932	28	bind	bind	VB
cord-001835-0s7ok4uw	932	29	to	to	IN
cord-001835-0s7ok4uw	932	30	the	the	DT
cord-001835-0s7ok4uw	932	31	enzyme	enzyme	NN
cord-001835-0s7ok4uw	932	32	and	and	CC
cord-001835-0s7ok4uw	932	33	glucose-6-P	glucose-6-p	NN
cord-001835-0s7ok4uw	932	34	the	the	DT
cord-001835-0s7ok4uw	932	35	last	last	JJ
cord-001835-0s7ok4uw	932	36	product	product	NN
cord-001835-0s7ok4uw	932	37	to	to	TO
cord-001835-0s7ok4uw	932	38	be	be	VB
cord-001835-0s7ok4uw	932	39	released	release	VBN
cord-001835-0s7ok4uw	932	40	.	.	.
cord-001835-0s7ok4uw	933	1	Also	also	RB
cord-001835-0s7ok4uw	933	2	,	,	,
cord-001835-0s7ok4uw	933	3	ligand	ligand	NN
cord-001835-0s7ok4uw	933	4	-	-	HYPH
cord-001835-0s7ok4uw	933	5	induced	induce	VBN
cord-001835-0s7ok4uw	933	6	conformational	conformational	JJ
cord-001835-0s7ok4uw	933	7	changes	change	NNS
cord-001835-0s7ok4uw	933	8	were	be	VBD
cord-001835-0s7ok4uw	933	9	determined	determine	VBN
cord-001835-0s7ok4uw	933	10	in	in	IN
cord-001835-0s7ok4uw	933	11	the	the	DT
cord-001835-0s7ok4uw	933	12	crystal	crystal	NN
cord-001835-0s7ok4uw	933	13	structures	structure	NNS
cord-001835-0s7ok4uw	933	14	.	.	.
cord-001835-0s7ok4uw	934	1	The	the	DT
cord-001835-0s7ok4uw	934	2	apo	apo	NNP
cord-001835-0s7ok4uw	934	3	,	,	,
cord-001835-0s7ok4uw	934	4	the	the	DT
cord-001835-0s7ok4uw	934	5	enzyme	enzyme	NN
cord-001835-0s7ok4uw	934	6	-	-	HYPH
cord-001835-0s7ok4uw	934	7	glucose	glucose	NN
cord-001835-0s7ok4uw	934	8	and	and	CC
cord-001835-0s7ok4uw	934	9	enzyme	enzyme	NN
cord-001835-0s7ok4uw	934	10	-	-	HYPH
cord-001835-0s7ok4uw	934	11	glucose	glucose	NN
cord-001835-0s7ok4uw	934	12	-	-	HYPH
cord-001835-0s7ok4uw	934	13	ADPbS	adpbs	NN
cord-001835-0s7ok4uw	934	14	structures	structure	NNS
cord-001835-0s7ok4uw	934	15	were	be	VBD
cord-001835-0s7ok4uw	934	16	determined	determine	VBN
cord-001835-0s7ok4uw	934	17	at	at	IN
cord-001835-0s7ok4uw	934	18	2.14	2.14	CD
cord-001835-0s7ok4uw	934	19	Å	å	NN
cord-001835-0s7ok4uw	934	20	,	,	,
cord-001835-0s7ok4uw	934	21	1.95	1.95	CD
cord-001835-0s7ok4uw	934	22	Å	å	NN
cord-001835-0s7ok4uw	934	23	and	and	CC
cord-001835-0s7ok4uw	934	24	2.44	2.44	CD
cord-001835-0s7ok4uw	934	25	Å	å	NN
cord-001835-0s7ok4uw	934	26	resolutions	resolution	NNS
cord-001835-0s7ok4uw	934	27	,	,	,
cord-001835-0s7ok4uw	934	28	respectively	respectively	RB
cord-001835-0s7ok4uw	934	29	.	.	.
cord-001835-0s7ok4uw	935	1	Structure	structure	NN
cord-001835-0s7ok4uw	935	2	analysis	analysis	NN
cord-001835-0s7ok4uw	935	3	reveals	reveal	VBZ
cord-001835-0s7ok4uw	935	4	that	that	IN
cord-001835-0s7ok4uw	935	5	glucose	glucose	NN
cord-001835-0s7ok4uw	935	6	binding	binding	NN
cord-001835-0s7ok4uw	935	7	provokes	provoke	VBZ
cord-001835-0s7ok4uw	935	8	major	major	JJ
cord-001835-0s7ok4uw	935	9	conformational	conformational	JJ
cord-001835-0s7ok4uw	935	10	changes	change	NNS
cord-001835-0s7ok4uw	935	11	in	in	IN
cord-001835-0s7ok4uw	935	12	the	the	DT
cord-001835-0s7ok4uw	935	13	perGK	perGK	NNP
cord-001835-0s7ok4uw	935	14	enzyme	enzyme	NN
cord-001835-0s7ok4uw	935	15	,	,	,
cord-001835-0s7ok4uw	935	16	whereas	whereas	IN
cord-001835-0s7ok4uw	935	17	ADP	ADP	NNP
cord-001835-0s7ok4uw	935	18	binding	binding	NN
cord-001835-0s7ok4uw	935	19	does	do	VBZ
cord-001835-0s7ok4uw	935	20	not	not	RB
cord-001835-0s7ok4uw	935	21	cause	cause	VB
cord-001835-0s7ok4uw	935	22	further	further	JJ
cord-001835-0s7ok4uw	935	23	changes	change	NNS
cord-001835-0s7ok4uw	935	24	in	in	IN
cord-001835-0s7ok4uw	935	25	the	the	DT
cord-001835-0s7ok4uw	935	26	conformation	conformation	NN
cord-001835-0s7ok4uw	935	27	of	of	IN
cord-001835-0s7ok4uw	935	28	the	the	DT
cord-001835-0s7ok4uw	935	29	protein	protein	NN
cord-001835-0s7ok4uw	935	30	.	.	.
cord-001835-0s7ok4uw	936	1	The	the	DT
cord-001835-0s7ok4uw	936	2	results	result	NNS
cord-001835-0s7ok4uw	936	3	show	show	VBP
cord-001835-0s7ok4uw	936	4	that	that	IN
cord-001835-0s7ok4uw	936	5	although	although	IN
cord-001835-0s7ok4uw	936	6	the	the	DT
cord-001835-0s7ok4uw	936	7	permutation	permutation	NN
cord-001835-0s7ok4uw	936	8	has	have	VBZ
cord-001835-0s7ok4uw	936	9	no	no	DT
cord-001835-0s7ok4uw	936	10	effect	effect	NN
cord-001835-0s7ok4uw	936	11	on	on	IN
cord-001835-0s7ok4uw	936	12	the	the	DT
cord-001835-0s7ok4uw	936	13	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	936	14	preference	preference	NN
cord-001835-0s7ok4uw	936	15	it	-PRON-	PRP
cord-001835-0s7ok4uw	936	16	provokes	provoke	VBZ
cord-001835-0s7ok4uw	936	17	a	a	DT
cord-001835-0s7ok4uw	936	18	change	change	NN
cord-001835-0s7ok4uw	936	19	in	in	IN
cord-001835-0s7ok4uw	936	20	the	the	DT
cord-001835-0s7ok4uw	936	21	substrate	substrate	NN
cord-001835-0s7ok4uw	936	22	binding	bind	VBG
cord-001835-0s7ok4uw	936	23	order	order	NN
cord-001835-0s7ok4uw	936	24	that	that	WDT
cord-001835-0s7ok4uw	936	25	correlates	correlate	VBZ
cord-001835-0s7ok4uw	936	26	well	well	RB
cord-001835-0s7ok4uw	936	27	with	with	IN
cord-001835-0s7ok4uw	936	28	that	that	IN
cord-001835-0s7ok4uw	936	29	those	those	DT
cord-001835-0s7ok4uw	936	30	observed	observe	VBN
cord-001835-0s7ok4uw	936	31	in	in	IN
cord-001835-0s7ok4uw	936	32	the	the	DT
cord-001835-0s7ok4uw	936	33	crystal	crystal	NN
cord-001835-0s7ok4uw	936	34	structures	structure	NNS
cord-001835-0s7ok4uw	936	35	.	.	.
cord-001835-0s7ok4uw	937	1	Also	also	RB
cord-001835-0s7ok4uw	937	2	,	,	,
cord-001835-0s7ok4uw	937	3	they	-PRON-	PRP
cord-001835-0s7ok4uw	937	4	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	937	5	that	that	IN
cord-001835-0s7ok4uw	937	6	during	during	IN
cord-001835-0s7ok4uw	937	7	the	the	DT
cord-001835-0s7ok4uw	937	8	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	937	9	history	history	NN
cord-001835-0s7ok4uw	937	10	of	of	IN
cord-001835-0s7ok4uw	937	11	the	the	DT
cord-001835-0s7ok4uw	937	12	ribokinase	ribokinase	NNP
cord-001835-0s7ok4uw	937	13	superfamily	superfamily	NN
cord-001835-0s7ok4uw	937	14	folding	fold	VBG
cord-001835-0s7ok4uw	937	15	topology	topology	NN
cord-001835-0s7ok4uw	937	16	dictates	dictate	VBZ
cord-001835-0s7ok4uw	937	17	the	the	DT
cord-001835-0s7ok4uw	937	18	substrate	substrate	NN
cord-001835-0s7ok4uw	937	19	binding	bind	VBG
cord-001835-0s7ok4uw	937	20	order	order	NN
cord-001835-0s7ok4uw	937	21	(	(	-LRB-
cord-001835-0s7ok4uw	937	22	Fondecyt	Fondecyt	NNP
cord-001835-0s7ok4uw	937	23	1150460	1150460	CD
cord-001835-0s7ok4uw	937	24	)	)	-RRB-
cord-001835-0s7ok4uw	937	25	.	.	.
cord-001835-0s7ok4uw	938	1	Background	background	NN
cord-001835-0s7ok4uw	938	2	:	:	:
cord-001835-0s7ok4uw	939	1	Human	human	JJ
cord-001835-0s7ok4uw	939	2	ceruloplasmin	ceruloplasmin	NN
cord-001835-0s7ok4uw	939	3	(	(	-LRB-
cord-001835-0s7ok4uw	939	4	CP	CP	NNP
cord-001835-0s7ok4uw	939	5	)	)	-RRB-
cord-001835-0s7ok4uw	939	6	is	be	VBZ
cord-001835-0s7ok4uw	939	7	a	a	DT
cord-001835-0s7ok4uw	939	8	circulating	circulate	VBG
cord-001835-0s7ok4uw	939	9	copper	copper	NN
cord-001835-0s7ok4uw	939	10	-	-	HYPH
cord-001835-0s7ok4uw	939	11	containing	contain	VBG
cord-001835-0s7ok4uw	939	12	glycoprotein	glycoprotein	NN
cord-001835-0s7ok4uw	939	13	produced	produce	VBN
cord-001835-0s7ok4uw	939	14	in	in	IN
cord-001835-0s7ok4uw	939	15	the	the	DT
cord-001835-0s7ok4uw	939	16	liver	liver	NN
cord-001835-0s7ok4uw	939	17	and	and	CC
cord-001835-0s7ok4uw	939	18	first	first	RB
cord-001835-0s7ok4uw	939	19	described	describe	VBN
cord-001835-0s7ok4uw	939	20	as	as	IN
cord-001835-0s7ok4uw	939	21	a	a	DT
cord-001835-0s7ok4uw	939	22	component	component	NN
cord-001835-0s7ok4uw	939	23	of	of	IN
cord-001835-0s7ok4uw	939	24	alpha2-globulin	alpha2-globulin	JJ
cord-001835-0s7ok4uw	939	25	fraction	fraction	NN
cord-001835-0s7ok4uw	939	26	of	of	IN
cord-001835-0s7ok4uw	939	27	human	human	JJ
cord-001835-0s7ok4uw	939	28	plasma	plasma	NN
cord-001835-0s7ok4uw	939	29	.	.	.
cord-001835-0s7ok4uw	940	1	CP	CP	NNP
cord-001835-0s7ok4uw	940	2	belongs	belong	VBZ
cord-001835-0s7ok4uw	940	3	to	to	IN
cord-001835-0s7ok4uw	940	4	the	the	DT
cord-001835-0s7ok4uw	940	5	multicopper	multicopper	NNP
cord-001835-0s7ok4uw	940	6	oxidase	oxidase	NNP
cord-001835-0s7ok4uw	940	7	family	family	NN
cord-001835-0s7ok4uw	940	8	and	and	CC
cord-001835-0s7ok4uw	940	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	940	10	is	be	VBZ
cord-001835-0s7ok4uw	940	11	nowadays	nowadays	RB
cord-001835-0s7ok4uw	940	12	regarded	regard	VBN
cord-001835-0s7ok4uw	940	13	as	as	IN
cord-001835-0s7ok4uw	940	14	a	a	DT
cord-001835-0s7ok4uw	940	15	"	"	``
cord-001835-0s7ok4uw	940	16	moonlighting	moonlight	VBG
cord-001835-0s7ok4uw	940	17	"	"	''
cord-001835-0s7ok4uw	940	18	protein	protein	NN
cord-001835-0s7ok4uw	940	19	,	,	,
cord-001835-0s7ok4uw	940	20	because	because	IN
cord-001835-0s7ok4uw	940	21	it	-PRON-	PRP
cord-001835-0s7ok4uw	940	22	changes	change	VBZ
cord-001835-0s7ok4uw	940	23	its	-PRON-	PRP$
cord-001835-0s7ok4uw	940	24	function	function	NN
cord-001835-0s7ok4uw	940	25	according	accord	VBG
cord-001835-0s7ok4uw	940	26	to	to	IN
cord-001835-0s7ok4uw	940	27	substrate	substrate	NN
cord-001835-0s7ok4uw	940	28	,	,	,
cord-001835-0s7ok4uw	940	29	localization	localization	NN
cord-001835-0s7ok4uw	940	30	and	and	CC
cord-001835-0s7ok4uw	940	31	expression	expression	NN
cord-001835-0s7ok4uw	940	32	.	.	.
cord-001835-0s7ok4uw	941	1	CP	CP	NNP
cord-001835-0s7ok4uw	941	2	plays	play	VBZ
cord-001835-0s7ok4uw	941	3	a	a	DT
cord-001835-0s7ok4uw	941	4	key	key	JJ
cord-001835-0s7ok4uw	941	5	role	role	NN
cord-001835-0s7ok4uw	941	6	in	in	IN
cord-001835-0s7ok4uw	941	7	copper	copper	NN
cord-001835-0s7ok4uw	941	8	transport	transport	NN
cord-001835-0s7ok4uw	941	9	and	and	CC
cord-001835-0s7ok4uw	941	10	iron	iron	NN
cord-001835-0s7ok4uw	941	11	metabolism	metabolism	NN
cord-001835-0s7ok4uw	941	12	and	and	CC
cord-001835-0s7ok4uw	941	13	it	-PRON-	PRP
cord-001835-0s7ok4uw	941	14	is	be	VBZ
cord-001835-0s7ok4uw	941	15	also	also	RB
cord-001835-0s7ok4uw	941	16	a	a	DT
cord-001835-0s7ok4uw	941	17	potent	potent	JJ
cord-001835-0s7ok4uw	941	18	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	941	19	of	of	IN
cord-001835-0s7ok4uw	941	20	leukocyte	leukocyte	NN
cord-001835-0s7ok4uw	941	21	myeloperoxidase	myeloperoxidase	NN
cord-001835-0s7ok4uw	941	22	(	(	-LRB-
cord-001835-0s7ok4uw	941	23	MPO	MPO	NNP
cord-001835-0s7ok4uw	941	24	)	)	-RRB-
cord-001835-0s7ok4uw	941	25	(	(	-LRB-
cord-001835-0s7ok4uw	941	26	Kd5130nM	Kd5130nM	NNP
cord-001835-0s7ok4uw	941	27	)	)	-RRB-
cord-001835-0s7ok4uw	941	28	,	,	,
cord-001835-0s7ok4uw	941	29	a	a	DT
cord-001835-0s7ok4uw	941	30	major	major	JJ
cord-001835-0s7ok4uw	941	31	source	source	NN
cord-001835-0s7ok4uw	941	32	of	of	IN
cord-001835-0s7ok4uw	941	33	oxidants	oxidant	NNS
cord-001835-0s7ok4uw	941	34	in	in	IN
cord-001835-0s7ok4uw	941	35	vivo	vivo	NNP
cord-001835-0s7ok4uw	941	36	.	.	.
cord-001835-0s7ok4uw	942	1	The	the	DT
cord-001835-0s7ok4uw	942	2	protein	protein	NN
cord-001835-0s7ok4uw	942	3	is	be	VBZ
cord-001835-0s7ok4uw	942	4	extremely	extremely	RB
cord-001835-0s7ok4uw	942	5	susceptible	susceptible	JJ
cord-001835-0s7ok4uw	942	6	to	to	IN
cord-001835-0s7ok4uw	942	7	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	942	8	.	.	.
cord-001835-0s7ok4uw	943	1	In	in	IN
cord-001835-0s7ok4uw	943	2	fact	fact	NN
cord-001835-0s7ok4uw	943	3	,	,	,
cord-001835-0s7ok4uw	943	4	CP	CP	NNP
cord-001835-0s7ok4uw	943	5	is	be	VBZ
cord-001835-0s7ok4uw	943	6	a	a	DT
cord-001835-0s7ok4uw	943	7	structural	structural	JJ
cord-001835-0s7ok4uw	943	8	homolog	homolog	NN
cord-001835-0s7ok4uw	943	9	of	of	IN
cord-001835-0s7ok4uw	943	10	coagulation	coagulation	NN
cord-001835-0s7ok4uw	943	11	factors	factor	NNS
cord-001835-0s7ok4uw	943	12	V	v	NN
cord-001835-0s7ok4uw	943	13	and	and	CC
cord-001835-0s7ok4uw	943	14	VIII	VIII	NNP
cord-001835-0s7ok4uw	943	15	,	,	,
cord-001835-0s7ok4uw	943	16	that	that	WDT
cord-001835-0s7ok4uw	943	17	are	be	VBP
cord-001835-0s7ok4uw	943	18	physiological	physiological	JJ
cord-001835-0s7ok4uw	943	19	substrates	substrate	NNS
cord-001835-0s7ok4uw	943	20	of	of	IN
cord-001835-0s7ok4uw	943	21	thrombin	thrombin	NN
cord-001835-0s7ok4uw	943	22	(	(	-LRB-
cord-001835-0s7ok4uw	943	23	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	943	24	)	)	-RRB-
cord-001835-0s7ok4uw	943	25	.	.	.
cord-001835-0s7ok4uw	944	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	944	2	,	,	,
cord-001835-0s7ok4uw	944	3	thrombin	thrombin	NN
cord-001835-0s7ok4uw	944	4	participates	participate	VBZ
cord-001835-0s7ok4uw	944	5	in	in	IN
cord-001835-0s7ok4uw	944	6	both	both	DT
cord-001835-0s7ok4uw	944	7	haemostatic	haemostatic	JJ
cord-001835-0s7ok4uw	944	8	and	and	CC
cord-001835-0s7ok4uw	944	9	inflammatory	inflammatory	JJ
cord-001835-0s7ok4uw	944	10	responses	response	NNS
cord-001835-0s7ok4uw	944	11	:	:	:
cord-001835-0s7ok4uw	944	12	in	in	IN
cord-001835-0s7ok4uw	944	13	some	some	DT
cord-001835-0s7ok4uw	944	14	focus	focus	NN
cord-001835-0s7ok4uw	944	15	of	of	IN
cord-001835-0s7ok4uw	944	16	inflammation	inflammation	NN
cord-001835-0s7ok4uw	944	17	,	,	,
cord-001835-0s7ok4uw	944	18	such	such	JJ
cord-001835-0s7ok4uw	944	19	as	as	IN
cord-001835-0s7ok4uw	944	20	rheumatoid	rheumatoid	NN
cord-001835-0s7ok4uw	944	21	arthritis	arthritis	NN
cord-001835-0s7ok4uw	944	22	(	(	-LRB-
cord-001835-0s7ok4uw	944	23	RA	RA	NNP
cord-001835-0s7ok4uw	944	24	)	)	-RRB-
cord-001835-0s7ok4uw	944	25	,	,	,
cord-001835-0s7ok4uw	944	26	the	the	DT
cord-001835-0s7ok4uw	944	27	high	high	JJ
cord-001835-0s7ok4uw	944	28	activity	activity	NN
cord-001835-0s7ok4uw	944	29	of	of	IN
cord-001835-0s7ok4uw	944	30	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	944	31	has	have	VBZ
cord-001835-0s7ok4uw	944	32	been	be	VBN
cord-001835-0s7ok4uw	944	33	documented	document	VBN
cord-001835-0s7ok4uw	944	34	.	.	.
cord-001835-0s7ok4uw	945	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	945	2	was	be	VBD
cord-001835-0s7ok4uw	945	3	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	945	4	that	that	IN
cord-001835-0s7ok4uw	945	5	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	945	6	can	can	MD
cord-001835-0s7ok4uw	945	7	promote	promote	VB
cord-001835-0s7ok4uw	945	8	the	the	DT
cord-001835-0s7ok4uw	945	9	chemotaxis	chemotaxis	NN
cord-001835-0s7ok4uw	945	10	of	of	IN
cord-001835-0s7ok4uw	945	11	neutrophils	neutrophil	NNS
cord-001835-0s7ok4uw	945	12	and	and	CC
cord-001835-0s7ok4uw	945	13	monocytes	monocyte	NNS
cord-001835-0s7ok4uw	945	14	and	and	CC
cord-001835-0s7ok4uw	945	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	945	16	adhesion	adhesion	NN
cord-001835-0s7ok4uw	945	17	to	to	IN
cord-001835-0s7ok4uw	945	18	endothelial	endothelial	JJ
cord-001835-0s7ok4uw	945	19	cells	cell	NNS
cord-001835-0s7ok4uw	945	20	,	,	,
cord-001835-0s7ok4uw	945	21	to	to	TO
cord-001835-0s7ok4uw	945	22	increase	increase	VB
cord-001835-0s7ok4uw	945	23	vascular	vascular	JJ
cord-001835-0s7ok4uw	945	24	permeability	permeability	NN
cord-001835-0s7ok4uw	945	25	.	.	.
cord-001835-0s7ok4uw	946	1	All	all	PDT
cord-001835-0s7ok4uw	946	2	these	these	DT
cord-001835-0s7ok4uw	946	3	effect	effect	NN
cord-001835-0s7ok4uw	946	4	are	be	VBP
cord-001835-0s7ok4uw	946	5	mediated	mediate	VBN
cord-001835-0s7ok4uw	946	6	by	by	IN
cord-001835-0s7ok4uw	946	7	PAR-1	PAR-1	NNP
cord-001835-0s7ok4uw	946	8	interaction	interaction	NN
cord-001835-0s7ok4uw	946	9	,	,	,
cord-001835-0s7ok4uw	946	10	that	that	WDT
cord-001835-0s7ok4uw	946	11	are	be	VBP
cord-001835-0s7ok4uw	946	12	abundantly	abundantly	RB
cord-001835-0s7ok4uw	946	13	expressed	express	VBN
cord-001835-0s7ok4uw	946	14	in	in	IN
cord-001835-0s7ok4uw	946	15	inflamed	inflamed	JJ
cord-001835-0s7ok4uw	946	16	rheumatoid	rheumatoid	JJ
cord-001835-0s7ok4uw	946	17	synovial	synovial	JJ
cord-001835-0s7ok4uw	946	18	tissues	tissue	NNS
cord-001835-0s7ok4uw	946	19	.	.	.
cord-001835-0s7ok4uw	947	1	Aims	aim	VBZ
cord-001835-0s7ok4uw	947	2	:	:	:
cord-001835-0s7ok4uw	948	1	In	in	IN
cord-001835-0s7ok4uw	948	2	this	this	DT
cord-001835-0s7ok4uw	948	3	study	study	NN
cord-001835-0s7ok4uw	948	4	the	the	DT
cord-001835-0s7ok4uw	948	5	interaction	interaction	NN
cord-001835-0s7ok4uw	948	6	of	of	IN
cord-001835-0s7ok4uw	948	7	CP	CP	NNP
cord-001835-0s7ok4uw	948	8	with	with	IN
cord-001835-0s7ok4uw	948	9	thrombin	thrombin	NN
cord-001835-0s7ok4uw	948	10	was	be	VBD
cord-001835-0s7ok4uw	948	11	investigated	investigate	VBN
cord-001835-0s7ok4uw	948	12	to	to	TO
cord-001835-0s7ok4uw	948	13	confirm	confirm	VB
cord-001835-0s7ok4uw	948	14	the	the	DT
cord-001835-0s7ok4uw	948	15	participation	participation	NN
cord-001835-0s7ok4uw	948	16	of	of	IN
cord-001835-0s7ok4uw	948	17	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	948	18	in	in	IN
cord-001835-0s7ok4uw	948	19	"	"	``
cord-001835-0s7ok4uw	948	20	spontaneous	spontaneous	JJ
cord-001835-0s7ok4uw	948	21	"	"	''
cord-001835-0s7ok4uw	948	22	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	948	23	degradation	degradation	NN
cord-001835-0s7ok4uw	948	24	of	of	IN
cord-001835-0s7ok4uw	948	25	CP	cp	NN
cord-001835-0s7ok4uw	948	26	.	.	.
cord-001835-0s7ok4uw	949	1	In	in	IN
cord-001835-0s7ok4uw	949	2	fact	fact	NN
cord-001835-0s7ok4uw	949	3	,	,	,
cord-001835-0s7ok4uw	949	4	in	in	IN
cord-001835-0s7ok4uw	949	5	vivo	vivo	FW
cord-001835-0s7ok4uw	949	6	the	the	DT
cord-001835-0s7ok4uw	949	7	integrity	integrity	NN
cord-001835-0s7ok4uw	949	8	of	of	IN
cord-001835-0s7ok4uw	949	9	CP	CP	NNP
cord-001835-0s7ok4uw	949	10	is	be	VBZ
cord-001835-0s7ok4uw	949	11	essential	essential	JJ
cord-001835-0s7ok4uw	949	12	for	for	IN
cord-001835-0s7ok4uw	949	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	949	14	role	role	NN
cord-001835-0s7ok4uw	949	15	in	in	IN
cord-001835-0s7ok4uw	949	16	the	the	DT
cord-001835-0s7ok4uw	949	17	transport	transport	NN
cord-001835-0s7ok4uw	949	18	or	or	CC
cord-001835-0s7ok4uw	949	19	metabolism	metabolism	NN
cord-001835-0s7ok4uw	949	20	of	of	IN
cord-001835-0s7ok4uw	949	21	copper	copper	NN
cord-001835-0s7ok4uw	949	22	.	.	.
cord-001835-0s7ok4uw	950	1	Results	result	NNS
cord-001835-0s7ok4uw	950	2	:	:	:
cord-001835-0s7ok4uw	951	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	951	2	results	result	NNS
cord-001835-0s7ok4uw	951	3	indicated	indicate	VBD
cord-001835-0s7ok4uw	951	4	that	that	IN
cord-001835-0s7ok4uw	951	5	thrombin	thrombin	NN
cord-001835-0s7ok4uw	951	6	cleaves	cleave	VBZ
cord-001835-0s7ok4uw	951	7	CP	CP	NNP
cord-001835-0s7ok4uw	951	8	in	in	IN
cord-001835-0s7ok4uw	951	9	vitro	vitro	FW
cord-001835-0s7ok4uw	951	10	at	at	IN
cord-001835-0s7ok4uw	951	11	481Arg	481arg	CD
cord-001835-0s7ok4uw	951	12	-	-	:
cord-001835-0s7ok4uw	951	13	Ser482	ser482	CD
cord-001835-0s7ok4uw	951	14	and	and	CC
cord-001835-0s7ok4uw	951	15	887Lys	887lys	CD
cord-001835-0s7ok4uw	951	16	-	-	HYPH
cord-001835-0s7ok4uw	951	17	Val888	val888	NN
cord-001835-0s7ok4uw	951	18	bonds	bond	NNS
cord-001835-0s7ok4uw	951	19	,	,	,
cord-001835-0s7ok4uw	951	20	generating	generate	VBG
cord-001835-0s7ok4uw	951	21	a	a	DT
cord-001835-0s7ok4uw	951	22	nicked	nick	VBN
cord-001835-0s7ok4uw	951	23	species	specie	NNS
cord-001835-0s7ok4uw	951	24	that	that	WDT
cord-001835-0s7ok4uw	951	25	retains	retain	VBZ
cord-001835-0s7ok4uw	951	26	the	the	DT
cord-001835-0s7ok4uw	951	27	native	native	JJ
cord-001835-0s7ok4uw	951	28	-	-	HYPH
cord-001835-0s7ok4uw	951	29	like	like	JJ
cord-001835-0s7ok4uw	951	30	fold	fold	NN
cord-001835-0s7ok4uw	951	31	and	and	CC
cord-001835-0s7ok4uw	951	32	the	the	DT
cord-001835-0s7ok4uw	951	33	ferroxidase	ferroxidase	NN
cord-001835-0s7ok4uw	951	34	activity	activity	NN
cord-001835-0s7ok4uw	951	35	of	of	IN
cord-001835-0s7ok4uw	951	36	the	the	DT
cord-001835-0s7ok4uw	951	37	intact	intact	JJ
cord-001835-0s7ok4uw	951	38	protein	protein	NN
cord-001835-0s7ok4uw	951	39	,	,	,
cord-001835-0s7ok4uw	951	40	whereas	whereas	IN
cord-001835-0s7ok4uw	951	41	the	the	DT
cord-001835-0s7ok4uw	951	42	MPO	MPO	NNP
cord-001835-0s7ok4uw	951	43	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	951	44	function	function	NN
cord-001835-0s7ok4uw	951	45	of	of	IN
cord-001835-0s7ok4uw	951	46	CP	CP	NNP
cord-001835-0s7ok4uw	951	47	is	be	VBZ
cord-001835-0s7ok4uw	951	48	abrogated	abrogate	VBN
cord-001835-0s7ok4uw	951	49	.	.	.
cord-001835-0s7ok4uw	952	1	Analysis	analysis	NN
cord-001835-0s7ok4uw	952	2	of	of	IN
cord-001835-0s7ok4uw	952	3	the	the	DT
cord-001835-0s7ok4uw	952	4	synovial	synovial	JJ
cord-001835-0s7ok4uw	952	5	fluid	fluid	NN
cord-001835-0s7ok4uw	952	6	of	of	IN
cord-001835-0s7ok4uw	952	7	24	24	CD
cord-001835-0s7ok4uw	952	8	RA	RA	NNP
cord-001835-0s7ok4uw	952	9	patients	patient	NNS
cord-001835-0s7ok4uw	952	10	reveals	reveal	VBZ
cord-001835-0s7ok4uw	952	11	that	that	IN
cord-001835-0s7ok4uw	952	12	CP	CP	NNP
cord-001835-0s7ok4uw	952	13	is	be	VBZ
cord-001835-0s7ok4uw	952	14	proteolytically	proteolytically	RB
cord-001835-0s7ok4uw	952	15	degraded	degrade	VBN
cord-001835-0s7ok4uw	952	16	to	to	IN
cord-001835-0s7ok4uw	952	17	a	a	DT
cord-001835-0s7ok4uw	952	18	variable	variable	JJ
cord-001835-0s7ok4uw	952	19	extent	extent	NN
cord-001835-0s7ok4uw	952	20	,	,	,
cord-001835-0s7ok4uw	952	21	with	with	IN
cord-001835-0s7ok4uw	952	22	a	a	DT
cord-001835-0s7ok4uw	952	23	fragmentation	fragmentation	NN
cord-001835-0s7ok4uw	952	24	pattern	pattern	NN
cord-001835-0s7ok4uw	952	25	similar	similar	JJ
cord-001835-0s7ok4uw	952	26	to	to	IN
cord-001835-0s7ok4uw	952	27	that	that	DT
cord-001835-0s7ok4uw	952	28	observed	observe	VBN
cord-001835-0s7ok4uw	952	29	with	with	IN
cord-001835-0s7ok4uw	952	30	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	952	31	in	in	IN
cord-001835-0s7ok4uw	952	32	vitro	vitro	FW
cord-001835-0s7ok4uw	952	33	,	,	,
cord-001835-0s7ok4uw	952	34	and	and	CC
cord-001835-0s7ok4uw	952	35	that	that	IN
cord-001835-0s7ok4uw	952	36	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	952	37	is	be	VBZ
cord-001835-0s7ok4uw	952	38	blocked	block	VBN
cord-001835-0s7ok4uw	952	39	by	by	IN
cord-001835-0s7ok4uw	952	40	hirudin	hirudin	NN
cord-001835-0s7ok4uw	952	41	,	,	,
cord-001835-0s7ok4uw	952	42	a	a	DT
cord-001835-0s7ok4uw	952	43	highly	highly	RB
cord-001835-0s7ok4uw	952	44	potent	potent	JJ
cord-001835-0s7ok4uw	952	45	and	and	CC
cord-001835-0s7ok4uw	952	46	specific	specific	JJ
cord-001835-0s7ok4uw	952	47	thrombin	thrombin	JJ
cord-001835-0s7ok4uw	952	48	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	952	49	.	.	.
cord-001835-0s7ok4uw	953	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	953	2	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	953	3	that	that	IN
cord-001835-0s7ok4uw	953	4	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	953	5	has	have	VBZ
cord-001835-0s7ok4uw	953	6	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	953	7	affinity	affinity	NN
cord-001835-0s7ok4uw	953	8	for	for	IN
cord-001835-0s7ok4uw	953	9	CP	cp	NN
cord-001835-0s7ok4uw	954	1	(	(	-LRB-
cord-001835-0s7ok4uw	954	2	Kd	Kd	NNP
cord-001835-0s7ok4uw	954	3	5	5	CD
cord-001835-0s7ok4uw	954	4	60	60	CD
cord-001835-0s7ok4uw	954	5	-	-	SYM
cord-001835-0s7ok4uw	954	6	270	270	CD
cord-001835-0s7ok4uw	954	7	nM	nm	CD
cord-001835-0s7ok4uw	954	8	)	)	-RRB-
cord-001835-0s7ok4uw	954	9	,	,	,
cord-001835-0s7ok4uw	954	10	independently	independently	RB
cord-001835-0s7ok4uw	954	11	of	of	IN
cord-001835-0s7ok4uw	954	12	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	954	13	,	,	,
cord-001835-0s7ok4uw	954	14	and	and	CC
cord-001835-0s7ok4uw	954	15	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	954	16	CP	cp	NN
cord-001835-0s7ok4uw	954	17	ferroxidase	ferroxidase	NN
cord-001835-0s7ok4uw	954	18	activity	activity	NN
cord-001835-0s7ok4uw	955	1	(	(	-LRB-
cord-001835-0s7ok4uw	955	2	KI	KI	NNP
cord-001835-0s7ok4uw	955	3	5	5	CD
cord-001835-0s7ok4uw	955	4	220	220	CD
cord-001835-0s7ok4uw	955	5	6	6	CD
cord-001835-0s7ok4uw	955	6	20	20	CD
cord-001835-0s7ok4uw	955	7	nM	nm	CD
cord-001835-0s7ok4uw	955	8	)	)	-RRB-
cord-001835-0s7ok4uw	955	9	.	.	.
cord-001835-0s7ok4uw	956	1	Mapping	mapping	NN
cord-001835-0s7ok4uw	956	2	of	of	IN
cord-001835-0s7ok4uw	956	3	thrombin	thrombin	JJ
cord-001835-0s7ok4uw	956	4	binding	bind	VBG
cord-001835-0s7ok4uw	956	5	sites	site	NNS
cord-001835-0s7ok4uw	956	6	with	with	IN
cord-001835-0s7ok4uw	956	7	specific	specific	JJ
cord-001835-0s7ok4uw	956	8	exosite	exosite	NN
cord-001835-0s7ok4uw	956	9	-	-	HYPH
cord-001835-0s7ok4uw	956	10	directed	direct	VBN
cord-001835-0s7ok4uw	956	11	ligands	ligand	NNS
cord-001835-0s7ok4uw	956	12	(	(	-LRB-
cord-001835-0s7ok4uw	956	13	i.e.	i.e.	FW
cord-001835-0s7ok4uw	956	14	hirugen	hirugen	NNP
cord-001835-0s7ok4uw	956	15	,	,	,
cord-001835-0s7ok4uw	956	16	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	956	17	gamma	gamma	NN
cord-001835-0s7ok4uw	956	18	-	-	HYPH
cord-001835-0s7ok4uw	956	19	peptide	peptide	NN
cord-001835-0s7ok4uw	956	20	)	)	-RRB-
cord-001835-0s7ok4uw	956	21	and	and	CC
cord-001835-0s7ok4uw	956	22	thrombin	thrombin	JJ
cord-001835-0s7ok4uw	956	23	analogues	analogue	NNS
cord-001835-0s7ok4uw	956	24	having	have	VBG
cord-001835-0s7ok4uw	956	25	the	the	DT
cord-001835-0s7ok4uw	956	26	exosites	exosite	NNS
cord-001835-0s7ok4uw	956	27	variably	variably	RB
cord-001835-0s7ok4uw	956	28	compromised	compromise	VBN
cord-001835-0s7ok4uw	956	29	(	(	-LRB-
cord-001835-0s7ok4uw	956	30	i.e.	i.e.	FW
cord-001835-0s7ok4uw	956	31	prothrombin	prothrombin	NN
cord-001835-0s7ok4uw	956	32	,	,	,
cord-001835-0s7ok4uw	956	33	prethrombin-2	prethrombin-2	RB
cord-001835-0s7ok4uw	956	34	,	,	,
cord-001835-0s7ok4uw	956	35	alpha	alpha	NN
cord-001835-0s7ok4uw	956	36	-	-	HYPH
cord-001835-0s7ok4uw	956	37	thrombin	thrombin	JJ
cord-001835-0s7ok4uw	956	38	)	)	-RRB-
cord-001835-0s7ok4uw	956	39	,	,	,
cord-001835-0s7ok4uw	956	40	reveals	reveal	VBZ
cord-001835-0s7ok4uw	956	41	that	that	IN
cord-001835-0s7ok4uw	956	42	the	the	DT
cord-001835-0s7ok4uw	956	43	positively	positively	RB
cord-001835-0s7ok4uw	956	44	charged	charge	VBN
cord-001835-0s7ok4uw	956	45	exosite	exosite	NNP
cord-001835-0s7ok4uw	956	46	-	-	HYPH
cord-001835-0s7ok4uw	956	47	II	II	NNP
cord-001835-0s7ok4uw	956	48	of	of	IN
cord-001835-0s7ok4uw	956	49	thrombin	thrombin	NN
cord-001835-0s7ok4uw	956	50	binds	bind	VBZ
cord-001835-0s7ok4uw	956	51	to	to	IN
cord-001835-0s7ok4uw	956	52	the	the	DT
cord-001835-0s7ok4uw	956	53	negative	negative	JJ
cord-001835-0s7ok4uw	956	54	upper	upper	JJ
cord-001835-0s7ok4uw	956	55	region	region	NN
cord-001835-0s7ok4uw	956	56	of	of	IN
cord-001835-0s7ok4uw	956	57	CP	CP	NNP
cord-001835-0s7ok4uw	956	58	,	,	,
cord-001835-0s7ok4uw	956	59	while	while	IN
cord-001835-0s7ok4uw	956	60	the	the	DT
cord-001835-0s7ok4uw	956	61	protease	protease	NN
cord-001835-0s7ok4uw	956	62	active	active	JJ
cord-001835-0s7ok4uw	956	63	site	site	NN
cord-001835-0s7ok4uw	956	64	and	and	CC
cord-001835-0s7ok4uw	956	65	exosite	exosite	NN
cord-001835-0s7ok4uw	956	66	-	-	:
cord-001835-0s7ok4uw	956	67	I	-PRON-	PRP
cord-001835-0s7ok4uw	956	68	remain	remain	VBP
cord-001835-0s7ok4uw	956	69	accessible	accessible	JJ
cord-001835-0s7ok4uw	956	70	.	.	.
cord-001835-0s7ok4uw	957	1	These	these	DT
cord-001835-0s7ok4uw	957	2	results	result	NNS
cord-001835-0s7ok4uw	957	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	957	4	that	that	IN
cord-001835-0s7ok4uw	957	5	thrombin	thrombin	NN
cord-001835-0s7ok4uw	957	6	can	can	MD
cord-001835-0s7ok4uw	957	7	exacerbate	exacerbate	VB
cord-001835-0s7ok4uw	957	8	inflammation	inflammation	NN
cord-001835-0s7ok4uw	957	9	in	in	IN
cord-001835-0s7ok4uw	957	10	RA	RA	NNP
cord-001835-0s7ok4uw	957	11	by	by	IN
cord-001835-0s7ok4uw	957	12	impairing	impair	VBG
cord-001835-0s7ok4uw	957	13	via	via	IN
cord-001835-0s7ok4uw	957	14	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	957	15	the	the	DT
cord-001835-0s7ok4uw	957	16	MPO	MPO	NNP
cord-001835-0s7ok4uw	957	17	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	957	18	function	function	NN
cord-001835-0s7ok4uw	957	19	of	of	IN
cord-001835-0s7ok4uw	957	20	CP	CP	NNP
cord-001835-0s7ok4uw	957	21	and	and	CC
cord-001835-0s7ok4uw	957	22	by	by	IN
cord-001835-0s7ok4uw	957	23	competitively	competitively	RB
cord-001835-0s7ok4uw	957	24	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	957	25	CP	cp	NN
cord-001835-0s7ok4uw	957	26	ferroxidase	ferroxidase	NN
cord-001835-0s7ok4uw	957	27	activity	activity	NN
cord-001835-0s7ok4uw	957	28	.	.	.
cord-001835-0s7ok4uw	958	1	An	an	DT
cord-001835-0s7ok4uw	958	2	artificial	artificial	JJ
cord-001835-0s7ok4uw	958	3	pathway	pathway	NN
cord-001835-0s7ok4uw	958	4	for	for	IN
cord-001835-0s7ok4uw	958	5	isobutene	isobutene	JJ
cord-001835-0s7ok4uw	958	6	production	production	NN
cord-001835-0s7ok4uw	958	7	by	by	IN
cord-001835-0s7ok4uw	958	8	direct	direct	JJ
cord-001835-0s7ok4uw	958	9	fermentation	fermentation	NN
cord-001835-0s7ok4uw	958	10	:	:	:
cord-001835-0s7ok4uw	958	11	combining	combine	VBG
cord-001835-0s7ok4uw	958	12	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	958	13	engineering	engineering	NN
cord-001835-0s7ok4uw	958	14	and	and	CC
cord-001835-0s7ok4uw	958	15	protein	protein	NN
cord-001835-0s7ok4uw	958	16	engineering	engineering	NN
cord-001835-0s7ok4uw	958	17	Benoit	Benoit	NNP
cord-001835-0s7ok4uw	958	18	Villiers	Villiers	NNP
cord-001835-0s7ok4uw	958	19	1	1	CD
cord-001835-0s7ok4uw	958	20	,	,	,
cord-001835-0s7ok4uw	959	1	Franc¸ois	Franc¸ois	NNP
cord-001835-0s7ok4uw	959	2	Stricher	Stricher	NNP
cord-001835-0s7ok4uw	959	3	1	1	CD
cord-001835-0s7ok4uw	959	4	1	1	CD
cord-001835-0s7ok4uw	960	1	The	the	DT
cord-001835-0s7ok4uw	960	2	purpose	purpose	NN
cord-001835-0s7ok4uw	960	3	of	of	IN
cord-001835-0s7ok4uw	960	4	Global	Global	NNP
cord-001835-0s7ok4uw	960	5	Bioenergies	Bioenergies	NNPS
cord-001835-0s7ok4uw	960	6	is	be	VBZ
cord-001835-0s7ok4uw	960	7	to	to	TO
cord-001835-0s7ok4uw	960	8	develop	develop	VB
cord-001835-0s7ok4uw	960	9	innovative	innovative	JJ
cord-001835-0s7ok4uw	960	10	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	960	11	pathways	pathway	NNS
cord-001835-0s7ok4uw	960	12	for	for	IN
cord-001835-0s7ok4uw	960	13	the	the	DT
cord-001835-0s7ok4uw	960	14	production	production	NN
cord-001835-0s7ok4uw	960	15	of	of	IN
cord-001835-0s7ok4uw	960	16	light	light	JJ
cord-001835-0s7ok4uw	960	17	olefins	olefin	NNS
cord-001835-0s7ok4uw	960	18	from	from	IN
cord-001835-0s7ok4uw	960	19	renewable	renewable	JJ
cord-001835-0s7ok4uw	960	20	resources	resource	NNS
cord-001835-0s7ok4uw	960	21	,	,	,
cord-001835-0s7ok4uw	960	22	by	by	IN
cord-001835-0s7ok4uw	960	23	direct	direct	JJ
cord-001835-0s7ok4uw	960	24	fermentation	fermentation	NN
cord-001835-0s7ok4uw	960	25	.	.	.
cord-001835-0s7ok4uw	961	1	Light	light	JJ
cord-001835-0s7ok4uw	961	2	olefins	olefin	NNS
cord-001835-0s7ok4uw	961	3	(	(	-LRB-
cord-001835-0s7ok4uw	961	4	ethylene	ethylene	NN
cord-001835-0s7ok4uw	961	5	,	,	,
cord-001835-0s7ok4uw	961	6	propylene	propylene	NN
cord-001835-0s7ok4uw	961	7	,	,	,
cord-001835-0s7ok4uw	961	8	linear	linear	NNP
cord-001835-0s7ok4uw	961	9	butylene	butylene	NNP
cord-001835-0s7ok4uw	961	10	,	,	,
cord-001835-0s7ok4uw	961	11	isobutene	isobutene	NN
cord-001835-0s7ok4uw	961	12	and	and	CC
cord-001835-0s7ok4uw	961	13	butadiene	butadiene	NN
cord-001835-0s7ok4uw	961	14	)	)	-RRB-
cord-001835-0s7ok4uw	961	15	are	be	VBP
cord-001835-0s7ok4uw	961	16	the	the	DT
cord-001835-0s7ok4uw	961	17	core	core	NN
cord-001835-0s7ok4uw	961	18	of	of	IN
cord-001835-0s7ok4uw	961	19	the	the	DT
cord-001835-0s7ok4uw	961	20	petrochemical	petrochemical	NN
cord-001835-0s7ok4uw	961	21	industry	industry	NN
cord-001835-0s7ok4uw	961	22	.	.	.
cord-001835-0s7ok4uw	962	1	However	however	RB
cord-001835-0s7ok4uw	962	2	,	,	,
cord-001835-0s7ok4uw	962	3	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	962	4	do	do	VBP
cord-001835-0s7ok4uw	962	5	not	not	RB
cord-001835-0s7ok4uw	962	6	naturally	naturally	RB
cord-001835-0s7ok4uw	962	7	produce	produce	VB
cord-001835-0s7ok4uw	962	8	light	light	JJ
cord-001835-0s7ok4uw	962	9	olefins	olefin	NNS
cord-001835-0s7ok4uw	962	10	and	and	CC
cord-001835-0s7ok4uw	962	11	no	no	DT
cord-001835-0s7ok4uw	962	12	bioprocess	bioprocess	NN
cord-001835-0s7ok4uw	962	13	to	to	TO
cord-001835-0s7ok4uw	962	14	convert	convert	VB
cord-001835-0s7ok4uw	962	15	renewable	renewable	JJ
cord-001835-0s7ok4uw	962	16	resources	resource	NNS
cord-001835-0s7ok4uw	962	17	to	to	IN
cord-001835-0s7ok4uw	962	18	these	these	DT
cord-001835-0s7ok4uw	962	19	molecules	molecule	NNS
cord-001835-0s7ok4uw	962	20	has	have	VBZ
cord-001835-0s7ok4uw	962	21	been	be	VBN
cord-001835-0s7ok4uw	962	22	industrialized	industrialize	VBN
cord-001835-0s7ok4uw	962	23	so	so	RB
cord-001835-0s7ok4uw	962	24	far	far	RB
cord-001835-0s7ok4uw	962	25	.	.	.
cord-001835-0s7ok4uw	963	1	Global	Global	NNP
cord-001835-0s7ok4uw	963	2	Bioenergies	Bioenergies	NNPS
cord-001835-0s7ok4uw	963	3	has	have	VBZ
cord-001835-0s7ok4uw	963	4	developed	develop	VBN
cord-001835-0s7ok4uw	963	5	an	an	DT
cord-001835-0s7ok4uw	963	6	artificial	artificial	JJ
cord-001835-0s7ok4uw	963	7	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	963	8	pathway	pathway	NN
cord-001835-0s7ok4uw	963	9	including	include	VBG
cord-001835-0s7ok4uw	963	10	all	all	PDT
cord-001835-0s7ok4uw	963	11	the	the	DT
cord-001835-0s7ok4uw	963	12	necessary	necessary	JJ
cord-001835-0s7ok4uw	963	13	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	963	14	reactions	reaction	NNS
cord-001835-0s7ok4uw	963	15	from	from	IN
cord-001835-0s7ok4uw	963	16	feedstock	feedstock	NN
cord-001835-0s7ok4uw	963	17	to	to	IN
cord-001835-0s7ok4uw	963	18	isobutene	isobutene	NN
cord-001835-0s7ok4uw	963	19	.	.	.
cord-001835-0s7ok4uw	964	1	The	the	DT
cord-001835-0s7ok4uw	964	2	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	964	3	route	route	NN
cord-001835-0s7ok4uw	964	4	leading	lead	VBG
cord-001835-0s7ok4uw	964	5	to	to	IN
cord-001835-0s7ok4uw	964	6	isobutene	isobutene	NN
cord-001835-0s7ok4uw	964	7	can	can	MD
cord-001835-0s7ok4uw	964	8	be	be	VB
cord-001835-0s7ok4uw	964	9	divided	divide	VBN
cord-001835-0s7ok4uw	964	10	in	in	IN
cord-001835-0s7ok4uw	964	11	three	three	CD
cord-001835-0s7ok4uw	964	12	parts	part	NNS
cord-001835-0s7ok4uw	964	13	,	,	,
cord-001835-0s7ok4uw	964	14	the	the	DT
cord-001835-0s7ok4uw	964	15	first	first	JJ
cord-001835-0s7ok4uw	964	16	one	one	NN
cord-001835-0s7ok4uw	964	17	being	be	VBG
cord-001835-0s7ok4uw	964	18	the	the	DT
cord-001835-0s7ok4uw	964	19	use	use	NN
cord-001835-0s7ok4uw	964	20	of	of	IN
cord-001835-0s7ok4uw	964	21	natural	natural	JJ
cord-001835-0s7ok4uw	964	22	reactions	reaction	NNS
cord-001835-0s7ok4uw	964	23	occurring	occur	VBG
cord-001835-0s7ok4uw	964	24	in	in	IN
cord-001835-0s7ok4uw	964	25	the	the	DT
cord-001835-0s7ok4uw	964	26	host	host	NN
cord-001835-0s7ok4uw	964	27	microorganism	microorganism	NN
cord-001835-0s7ok4uw	964	28	.	.	.
cord-001835-0s7ok4uw	965	1	Second	second	RB
cord-001835-0s7ok4uw	965	2	,	,	,
cord-001835-0s7ok4uw	965	3	heterologous	heterologous	JJ
cord-001835-0s7ok4uw	965	4	natural	natural	JJ
cord-001835-0s7ok4uw	965	5	reactions	reaction	NNS
cord-001835-0s7ok4uw	965	6	were	be	VBD
cord-001835-0s7ok4uw	965	7	introduced	introduce	VBN
cord-001835-0s7ok4uw	965	8	into	into	IN
cord-001835-0s7ok4uw	965	9	the	the	DT
cord-001835-0s7ok4uw	965	10	same	same	JJ
cord-001835-0s7ok4uw	965	11	host	host	NN
cord-001835-0s7ok4uw	965	12	microorganism	microorganism	NN
cord-001835-0s7ok4uw	965	13	.	.	.
cord-001835-0s7ok4uw	966	1	Finally	finally	RB
cord-001835-0s7ok4uw	966	2	,	,	,
cord-001835-0s7ok4uw	966	3	in	in	IN
cord-001835-0s7ok4uw	966	4	contrast	contrast	NN
cord-001835-0s7ok4uw	966	5	with	with	IN
cord-001835-0s7ok4uw	966	6	most	most	JJS
cord-001835-0s7ok4uw	966	7	former	former	JJ
cord-001835-0s7ok4uw	966	8	approaches	approach	NNS
cord-001835-0s7ok4uw	966	9	,	,	,
cord-001835-0s7ok4uw	966	10	non	non	NNS
cord-001835-0s7ok4uw	966	11	-	-	JJ
cord-001835-0s7ok4uw	966	12	naturally	naturally	RB
cord-001835-0s7ok4uw	966	13	occurring	occur	VBG
cord-001835-0s7ok4uw	966	14	reactions	reaction	NNS
cord-001835-0s7ok4uw	966	15	as	as	IN
cord-001835-0s7ok4uw	966	16	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	966	17	key	key	JJ
cord-001835-0s7ok4uw	966	18	steps	step	NNS
cord-001835-0s7ok4uw	966	19	were	be	VBD
cord-001835-0s7ok4uw	966	20	used	use	VBN
cord-001835-0s7ok4uw	966	21	,	,	,
cord-001835-0s7ok4uw	966	22	for	for	IN
cord-001835-0s7ok4uw	966	23	example	example	NN
cord-001835-0s7ok4uw	966	24	the	the	DT
cord-001835-0s7ok4uw	966	25	decarboxylation	decarboxylation	NN
cord-001835-0s7ok4uw	966	26	of	of	IN
cord-001835-0s7ok4uw	966	27	hydroxyisovaleric	hydroxyisovaleric	JJ
cord-001835-0s7ok4uw	966	28	acid	acid	NN
cord-001835-0s7ok4uw	966	29	into	into	IN
cord-001835-0s7ok4uw	966	30	isobutene	isobutene	NN
cord-001835-0s7ok4uw	966	31	.	.	.
cord-001835-0s7ok4uw	967	1	Such	such	JJ
cord-001835-0s7ok4uw	967	2	non	non	JJ
cord-001835-0s7ok4uw	967	3	-	-	JJ
cord-001835-0s7ok4uw	967	4	natural	natural	JJ
cord-001835-0s7ok4uw	967	5	critical	critical	JJ
cord-001835-0s7ok4uw	967	6	steps	step	NNS
cord-001835-0s7ok4uw	967	7	were	be	VBD
cord-001835-0s7ok4uw	967	8	made	make	VBN
cord-001835-0s7ok4uw	967	9	possible	possible	JJ
cord-001835-0s7ok4uw	967	10	by	by	IN
cord-001835-0s7ok4uw	967	11	taking	take	VBG
cord-001835-0s7ok4uw	967	12	advantages	advantage	NNS
cord-001835-0s7ok4uw	967	13	of	of	IN
cord-001835-0s7ok4uw	967	14	the	the	DT
cord-001835-0s7ok4uw	967	15	natural	natural	JJ
cord-001835-0s7ok4uw	967	16	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	967	17	and	and	CC
cord-001835-0s7ok4uw	967	18	substrate	substrate	JJ
cord-001835-0s7ok4uw	967	19	promiscuity	promiscuity	NN
cord-001835-0s7ok4uw	967	20	of	of	IN
cord-001835-0s7ok4uw	967	21	exogenous	exogenous	JJ
cord-001835-0s7ok4uw	967	22	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	967	23	.	.	.
cord-001835-0s7ok4uw	968	1	Candidate	candidate	NN
cord-001835-0s7ok4uw	968	2	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	968	3	are	be	VBP
cord-001835-0s7ok4uw	968	4	then	then	RB
cord-001835-0s7ok4uw	968	5	evolved	evolve	VBN
cord-001835-0s7ok4uw	968	6	using	use	VBG
cord-001835-0s7ok4uw	968	7	systematic	systematic	JJ
cord-001835-0s7ok4uw	968	8	,	,	,
cord-001835-0s7ok4uw	968	9	random	random	JJ
cord-001835-0s7ok4uw	968	10	and	and	CC
cord-001835-0s7ok4uw	968	11	semi	semi	JJ
cord-001835-0s7ok4uw	968	12	-	-	JJ
cord-001835-0s7ok4uw	968	13	rational	rational	JJ
cord-001835-0s7ok4uw	968	14	approaches	approach	NNS
cord-001835-0s7ok4uw	968	15	in	in	IN
cord-001835-0s7ok4uw	968	16	successive	successive	JJ
cord-001835-0s7ok4uw	968	17	rounds	round	NNS
cord-001835-0s7ok4uw	968	18	in	in	IN
cord-001835-0s7ok4uw	968	19	order	order	NN
cord-001835-0s7ok4uw	968	20	to	to	TO
cord-001835-0s7ok4uw	968	21	reach	reach	VB
cord-001835-0s7ok4uw	968	22	the	the	DT
cord-001835-0s7ok4uw	968	23	desired	desire	VBN
cord-001835-0s7ok4uw	968	24	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	968	25	efficiency	efficiency	NN
cord-001835-0s7ok4uw	968	26	.	.	.
cord-001835-0s7ok4uw	969	1	Since	since	IN
cord-001835-0s7ok4uw	969	2	all	all	PDT
cord-001835-0s7ok4uw	969	3	these	these	DT
cord-001835-0s7ok4uw	969	4	reactions	reaction	NNS
cord-001835-0s7ok4uw	969	5	are	be	VBP
cord-001835-0s7ok4uw	969	6	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	969	7	,	,	,
cord-001835-0s7ok4uw	969	8	isobutene	isobutene	NN
cord-001835-0s7ok4uw	969	9	can	can	MD
cord-001835-0s7ok4uw	969	10	be	be	VB
cord-001835-0s7ok4uw	969	11	obtained	obtain	VBN
cord-001835-0s7ok4uw	969	12	by	by	IN
cord-001835-0s7ok4uw	969	13	direct	direct	JJ
cord-001835-0s7ok4uw	969	14	fermentation	fermentation	NN
cord-001835-0s7ok4uw	969	15	,	,	,
cord-001835-0s7ok4uw	969	16	e.g.	e.g.	RB
cord-001835-0s7ok4uw	969	17	a	a	DT
cord-001835-0s7ok4uw	969	18	process	process	NN
cord-001835-0s7ok4uw	969	19	wherein	wherein	WRB
cord-001835-0s7ok4uw	969	20	all	all	PDT
cord-001835-0s7ok4uw	969	21	the	the	DT
cord-001835-0s7ok4uw	969	22	chemical	chemical	NN
cord-001835-0s7ok4uw	969	23	transformations	transformation	NNS
cord-001835-0s7ok4uw	969	24	are	be	VBP
cord-001835-0s7ok4uw	969	25	carried	carry	VBN
cord-001835-0s7ok4uw	969	26	on	on	RP
cord-001835-0s7ok4uw	969	27	by	by	IN
cord-001835-0s7ok4uw	969	28	the	the	DT
cord-001835-0s7ok4uw	969	29	host	host	NN
cord-001835-0s7ok4uw	969	30	microorganism	microorganism	NN
cord-001835-0s7ok4uw	969	31	.	.	.
cord-001835-0s7ok4uw	970	1	The	the	DT
cord-001835-0s7ok4uw	970	2	scale	scale	NN
cord-001835-0s7ok4uw	970	3	-	-	HYPH
cord-001835-0s7ok4uw	970	4	up	up	NN
cord-001835-0s7ok4uw	970	5	of	of	IN
cord-001835-0s7ok4uw	970	6	this	this	DT
cord-001835-0s7ok4uw	970	7	process	process	NN
cord-001835-0s7ok4uw	970	8	began	begin	VBD
cord-001835-0s7ok4uw	970	9	in	in	IN
cord-001835-0s7ok4uw	970	10	November	November	NNP
cord-001835-0s7ok4uw	970	11	2014	2014	CD
cord-001835-0s7ok4uw	970	12	in	in	IN
cord-001835-0s7ok4uw	970	13	a	a	DT
cord-001835-0s7ok4uw	970	14	pilot	pilot	NN
cord-001835-0s7ok4uw	970	15	plant	plant	NN
cord-001835-0s7ok4uw	970	16	installed	instal	VBN
cord-001835-0s7ok4uw	970	17	in	in	IN
cord-001835-0s7ok4uw	970	18	Pomacle	Pomacle	NNP
cord-001835-0s7ok4uw	970	19	-	-	HYPH
cord-001835-0s7ok4uw	970	20	Bazancourt	Bazancourt	NNP
cord-001835-0s7ok4uw	970	21	,	,	,
cord-001835-0s7ok4uw	970	22	France	France	NNP
cord-001835-0s7ok4uw	970	23	,	,	,
cord-001835-0s7ok4uw	970	24	with	with	IN
cord-001835-0s7ok4uw	970	25	an	an	DT
cord-001835-0s7ok4uw	970	26	annual	annual	JJ
cord-001835-0s7ok4uw	970	27	capacity	capacity	NN
cord-001835-0s7ok4uw	970	28	of	of	IN
cord-001835-0s7ok4uw	970	29	10	10	CD
cord-001835-0s7ok4uw	970	30	tons	ton	NNS
cord-001835-0s7ok4uw	970	31	of	of	IN
cord-001835-0s7ok4uw	970	32	oxidation	oxidation	NN
cord-001835-0s7ok4uw	970	33	-	-	HYPH
cord-001835-0s7ok4uw	970	34	grade	grade	NN
cord-001835-0s7ok4uw	970	35	isobutene	isobutene	NN
cord-001835-0s7ok4uw	970	36	.	.	.
cord-001835-0s7ok4uw	971	1	Importantly	importantly	RB
cord-001835-0s7ok4uw	971	2	,	,	,
cord-001835-0s7ok4uw	971	3	production	production	NN
cord-001835-0s7ok4uw	971	4	of	of	IN
cord-001835-0s7ok4uw	971	5	a	a	DT
cord-001835-0s7ok4uw	971	6	volatile	volatile	JJ
cord-001835-0s7ok4uw	971	7	compound	compound	NN
cord-001835-0s7ok4uw	971	8	such	such	JJ
cord-001835-0s7ok4uw	971	9	as	as	IN
cord-001835-0s7ok4uw	971	10	isobutene	isobutene	NN
cord-001835-0s7ok4uw	971	11	(	(	-LRB-
cord-001835-0s7ok4uw	971	12	and	and	CC
cord-001835-0s7ok4uw	971	13	other	other	JJ
cord-001835-0s7ok4uw	971	14	light	light	JJ
cord-001835-0s7ok4uw	971	15	olefins	olefin	NNS
cord-001835-0s7ok4uw	971	16	)	)	-RRB-
cord-001835-0s7ok4uw	971	17	by	by	IN
cord-001835-0s7ok4uw	971	18	direct	direct	JJ
cord-001835-0s7ok4uw	971	19	fermentation	fermentation	NN
cord-001835-0s7ok4uw	971	20	presents	present	VBZ
cord-001835-0s7ok4uw	971	21	two	two	CD
cord-001835-0s7ok4uw	971	22	major	major	JJ
cord-001835-0s7ok4uw	971	23	advantages	advantage	NNS
cord-001835-0s7ok4uw	971	24	:	:	:
cord-001835-0s7ok4uw	971	25	first	first	RB
cord-001835-0s7ok4uw	971	26	,	,	,
cord-001835-0s7ok4uw	971	27	the	the	DT
cord-001835-0s7ok4uw	971	28	product	product	NN
cord-001835-0s7ok4uw	971	29	is	be	VBZ
cord-001835-0s7ok4uw	971	30	spontaneously	spontaneously	RB
cord-001835-0s7ok4uw	971	31	removed	remove	VBN
cord-001835-0s7ok4uw	971	32	from	from	IN
cord-001835-0s7ok4uw	971	33	the	the	DT
cord-001835-0s7ok4uw	971	34	culture	culture	NN
cord-001835-0s7ok4uw	971	35	broth	broth	NN
cord-001835-0s7ok4uw	971	36	,	,	,
cord-001835-0s7ok4uw	971	37	which	which	WDT
cord-001835-0s7ok4uw	971	38	alleviates	alleviate	VBZ
cord-001835-0s7ok4uw	971	39	the	the	DT
cord-001835-0s7ok4uw	971	40	limitations	limitation	NNS
cord-001835-0s7ok4uw	971	41	linked	link	VBN
cord-001835-0s7ok4uw	971	42	with	with	IN
cord-001835-0s7ok4uw	971	43	titer	titer	NN
cord-001835-0s7ok4uw	971	44	issues	issue	NNS
cord-001835-0s7ok4uw	971	45	.	.	.
cord-001835-0s7ok4uw	972	1	Second	second	RB
cord-001835-0s7ok4uw	972	2	,	,	,
cord-001835-0s7ok4uw	972	3	the	the	DT
cord-001835-0s7ok4uw	972	4	purification	purification	NN
cord-001835-0s7ok4uw	972	5	process	process	NN
cord-001835-0s7ok4uw	972	6	is	be	VBZ
cord-001835-0s7ok4uw	972	7	considerably	considerably	RB
cord-001835-0s7ok4uw	972	8	easier	easy	JJR
cord-001835-0s7ok4uw	972	9	and	and	CC
cord-001835-0s7ok4uw	972	10	cheaper	cheap	JJR
cord-001835-0s7ok4uw	972	11	since	since	IN
cord-001835-0s7ok4uw	972	12	no	no	DT
cord-001835-0s7ok4uw	972	13	energy	energy	NN
cord-001835-0s7ok4uw	972	14	consuming	consume	VBG
cord-001835-0s7ok4uw	972	15	methods	method	NNS
cord-001835-0s7ok4uw	972	16	such	such	JJ
cord-001835-0s7ok4uw	972	17	as	as	IN
cord-001835-0s7ok4uw	972	18	distillation	distillation	NN
cord-001835-0s7ok4uw	972	19	or	or	CC
cord-001835-0s7ok4uw	972	20	phase	phase	NN
cord-001835-0s7ok4uw	972	21	separation	separation	NN
cord-001835-0s7ok4uw	972	22	are	be	VBP
cord-001835-0s7ok4uw	972	23	necessary	necessary	JJ
cord-001835-0s7ok4uw	972	24	to	to	TO
cord-001835-0s7ok4uw	972	25	purify	purify	VB
cord-001835-0s7ok4uw	972	26	the	the	DT
cord-001835-0s7ok4uw	972	27	end	end	NN
cord-001835-0s7ok4uw	972	28	product	product	NN
cord-001835-0s7ok4uw	972	29	.	.	.
cord-001835-0s7ok4uw	973	1	For	for	IN
cord-001835-0s7ok4uw	973	2	the	the	DT
cord-001835-0s7ok4uw	973	3	first	first	JJ
cord-001835-0s7ok4uw	973	4	time	time	NN
cord-001835-0s7ok4uw	973	5	,	,	,
cord-001835-0s7ok4uw	973	6	batches	batch	NNS
cord-001835-0s7ok4uw	973	7	of	of	IN
cord-001835-0s7ok4uw	973	8	industrially	industrially	RB
cord-001835-0s7ok4uw	973	9	produced	produce	VBN
cord-001835-0s7ok4uw	973	10	isobutene	isobutene	NN
cord-001835-0s7ok4uw	973	11	from	from	IN
cord-001835-0s7ok4uw	973	12	renewable	renewable	JJ
cord-001835-0s7ok4uw	973	13	resources	resource	NNS
cord-001835-0s7ok4uw	973	14	have	have	VBP
cord-001835-0s7ok4uw	973	15	been	be	VBN
cord-001835-0s7ok4uw	973	16	obtained	obtain	VBN
cord-001835-0s7ok4uw	973	17	in	in	IN
cord-001835-0s7ok4uw	973	18	the	the	DT
cord-001835-0s7ok4uw	973	19	first	first	JJ
cord-001835-0s7ok4uw	973	20	half	half	NN
cord-001835-0s7ok4uw	973	21	of	of	IN
cord-001835-0s7ok4uw	973	22	2015	2015	CD
cord-001835-0s7ok4uw	973	23	.	.	.
cord-001835-0s7ok4uw	974	1	This	this	DT
cord-001835-0s7ok4uw	974	2	isobutene	isobutene	NN
cord-001835-0s7ok4uw	974	3	has	have	VBZ
cord-001835-0s7ok4uw	974	4	been	be	VBN
cord-001835-0s7ok4uw	974	5	in	in	IN
cord-001835-0s7ok4uw	974	6	turn	turn	NN
cord-001835-0s7ok4uw	974	7	converted	convert	VBN
cord-001835-0s7ok4uw	974	8	into	into	IN
cord-001835-0s7ok4uw	974	9	isooctane	isooctane	NNP
cord-001835-0s7ok4uw	974	10	,	,	,
cord-001835-0s7ok4uw	974	11	an	an	DT
cord-001835-0s7ok4uw	974	12	additive	additive	NN
cord-001835-0s7ok4uw	974	13	currently	currently	RB
cord-001835-0s7ok4uw	974	14	used	use	VBN
cord-001835-0s7ok4uw	974	15	to	to	TO
cord-001835-0s7ok4uw	974	16	improve	improve	VB
cord-001835-0s7ok4uw	974	17	gasoline	gasoline	NN
cord-001835-0s7ok4uw	974	18	quality	quality	NN
cord-001835-0s7ok4uw	974	19	,	,	,
cord-001835-0s7ok4uw	974	20	which	which	WDT
cord-001835-0s7ok4uw	974	21	could	could	MD
cord-001835-0s7ok4uw	974	22	also	also	RB
cord-001835-0s7ok4uw	974	23	be	be	VB
cord-001835-0s7ok4uw	974	24	used	use	VBN
cord-001835-0s7ok4uw	974	25	as	as	IN
cord-001835-0s7ok4uw	974	26	a	a	DT
cord-001835-0s7ok4uw	974	27	standalone	standalone	JJ
cord-001835-0s7ok4uw	974	28	fuel	fuel	NN
cord-001835-0s7ok4uw	974	29	.	.	.
cord-001835-0s7ok4uw	975	1	A	a	DT
cord-001835-0s7ok4uw	975	2	demonstration	demonstration	NN
cord-001835-0s7ok4uw	975	3	plant	plant	NN
cord-001835-0s7ok4uw	975	4	is	be	VBZ
cord-001835-0s7ok4uw	975	5	planned	plan	VBN
cord-001835-0s7ok4uw	975	6	in	in	IN
cord-001835-0s7ok4uw	975	7	Leuna	Leuna	NNP
cord-001835-0s7ok4uw	975	8	,	,	,
cord-001835-0s7ok4uw	975	9	Germany	Germany	NNP
cord-001835-0s7ok4uw	975	10	,	,	,
cord-001835-0s7ok4uw	975	11	with	with	IN
cord-001835-0s7ok4uw	975	12	an	an	DT
cord-001835-0s7ok4uw	975	13	annual	annual	JJ
cord-001835-0s7ok4uw	975	14	capacity	capacity	NN
cord-001835-0s7ok4uw	975	15	of	of	IN
cord-001835-0s7ok4uw	975	16	100	100	CD
cord-001835-0s7ok4uw	975	17	tons	ton	NNS
cord-001835-0s7ok4uw	975	18	of	of	IN
cord-001835-0s7ok4uw	975	19	polymer	polymer	NN
cord-001835-0s7ok4uw	975	20	-	-	HYPH
cord-001835-0s7ok4uw	975	21	grade	grade	NN
cord-001835-0s7ok4uw	975	22	isobutene	isobutene	NN
cord-001835-0s7ok4uw	975	23	and	and	CC
cord-001835-0s7ok4uw	975	24	IBN	IBN	NNP
cord-001835-0s7ok4uw	975	25	-	-	HYPH
cord-001835-0s7ok4uw	975	26	One	One	NNP
cord-001835-0s7ok4uw	975	27	,	,	,
cord-001835-0s7ok4uw	975	28	a	a	DT
cord-001835-0s7ok4uw	975	29	joint	joint	JJ
cord-001835-0s7ok4uw	975	30	venture	venture	NN
cord-001835-0s7ok4uw	975	31	with	with	IN
cord-001835-0s7ok4uw	975	32	Cristal	Cristal	NNP
cord-001835-0s7ok4uw	975	33	Union	Union	NNP
cord-001835-0s7ok4uw	975	34	(	(	-LRB-
cord-001835-0s7ok4uw	975	35	4th	4th	JJ
cord-001835-0s7ok4uw	975	36	European	european	JJ
cord-001835-0s7ok4uw	975	37	beet	beet	NN
cord-001835-0s7ok4uw	975	38	processor	processor	NN
cord-001835-0s7ok4uw	975	39	)	)	-RRB-
cord-001835-0s7ok4uw	975	40	,	,	,
cord-001835-0s7ok4uw	975	41	has	have	VBZ
cord-001835-0s7ok4uw	975	42	been	be	VBN
cord-001835-0s7ok4uw	975	43	formed	form	VBN
cord-001835-0s7ok4uw	975	44	to	to	TO
cord-001835-0s7ok4uw	975	45	build	build	VB
cord-001835-0s7ok4uw	975	46	and	and	CC
cord-001835-0s7ok4uw	975	47	operate	operate	VB
cord-001835-0s7ok4uw	975	48	the	the	DT
cord-001835-0s7ok4uw	975	49	first	first	JJ
cord-001835-0s7ok4uw	975	50	plant	plant	NN
cord-001835-0s7ok4uw	975	51	in	in	IN
cord-001835-0s7ok4uw	975	52	France	France	NNP
cord-001835-0s7ok4uw	975	53	converting	convert	VBG
cord-001835-0s7ok4uw	975	54	renewable	renewable	JJ
cord-001835-0s7ok4uw	975	55	resources	resource	NNS
cord-001835-0s7ok4uw	975	56	into	into	IN
cord-001835-0s7ok4uw	975	57	isobutene	isobutene	NN
cord-001835-0s7ok4uw	975	58	.	.	.
cord-001835-0s7ok4uw	976	1	Finally	finally	RB
cord-001835-0s7ok4uw	976	2	,	,	,
cord-001835-0s7ok4uw	976	3	while	while	IN
cord-001835-0s7ok4uw	976	4	the	the	DT
cord-001835-0s7ok4uw	976	5	isobutene	isobutene	NN
cord-001835-0s7ok4uw	976	6	process	process	NN
cord-001835-0s7ok4uw	976	7	is	be	VBZ
cord-001835-0s7ok4uw	976	8	progressing	progress	VBG
cord-001835-0s7ok4uw	976	9	towards	towards	IN
cord-001835-0s7ok4uw	976	10	industrial	industrial	JJ
cord-001835-0s7ok4uw	976	11	scale	scale	NN
cord-001835-0s7ok4uw	976	12	,	,	,
cord-001835-0s7ok4uw	976	13	Global	Global	NNP
cord-001835-0s7ok4uw	976	14	Bioenergies	Bioenergies	NNPS
cord-001835-0s7ok4uw	976	15	is	be	VBZ
cord-001835-0s7ok4uw	976	16	also	also	RB
cord-001835-0s7ok4uw	976	17	developing	develop	VBG
cord-001835-0s7ok4uw	976	18	new	new	JJ
cord-001835-0s7ok4uw	976	19	artificial	artificial	JJ
cord-001835-0s7ok4uw	976	20	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	976	21	pathways	pathway	NNS
cord-001835-0s7ok4uw	976	22	enabling	enable	VBG
cord-001835-0s7ok4uw	976	23	direct	direct	JJ
cord-001835-0s7ok4uw	976	24	bio	bio	NN
cord-001835-0s7ok4uw	976	25	-	-	NN
cord-001835-0s7ok4uw	976	26	production	production	NN
cord-001835-0s7ok4uw	976	27	of	of	IN
cord-001835-0s7ok4uw	976	28	Butadiene	Butadiene	NNP
cord-001835-0s7ok4uw	976	29	and	and	CC
cord-001835-0s7ok4uw	976	30	Propylene	Propylene	NNP
cord-001835-0s7ok4uw	976	31	.	.	.
cord-001835-0s7ok4uw	977	1	The	the	DT
cord-001835-0s7ok4uw	977	2	development	development	NN
cord-001835-0s7ok4uw	977	3	of	of	IN
cord-001835-0s7ok4uw	977	4	a	a	DT
cord-001835-0s7ok4uw	977	5	coupled	couple	VBN
cord-001835-0s7ok4uw	977	6	enzyme	enzyme	NN
cord-001835-0s7ok4uw	977	7	assay	assay	NN
cord-001835-0s7ok4uw	977	8	to	to	TO
cord-001835-0s7ok4uw	977	9	detect	detect	VB
cord-001835-0s7ok4uw	977	10	isochorismate	isochorismate	NNP
cord-001835-0s7ok4uw	977	11	pyruvate	pyruvate	NN
cord-001835-0s7ok4uw	977	12	lyase	lyase	NN
cord-001835-0s7ok4uw	977	13	activity	activity	NN
cord-001835-0s7ok4uw	977	14	Protein	protein	NN
cord-001835-0s7ok4uw	977	15	folding	folding	NN
cord-001835-0s7ok4uw	977	16	is	be	VBZ
cord-001835-0s7ok4uw	977	17	typically	typically	RB
cord-001835-0s7ok4uw	977	18	defined	define	VBN
cord-001835-0s7ok4uw	977	19	in	in	IN
cord-001835-0s7ok4uw	977	20	terms	term	NNS
cord-001835-0s7ok4uw	977	21	of	of	IN
cord-001835-0s7ok4uw	977	22	the	the	DT
cord-001835-0s7ok4uw	977	23	spatial	spatial	JJ
cord-001835-0s7ok4uw	977	24	arrangement	arrangement	NN
cord-001835-0s7ok4uw	977	25	of	of	IN
cord-001835-0s7ok4uw	977	26	structural	structural	JJ
cord-001835-0s7ok4uw	977	27	elements	element	NNS
cord-001835-0s7ok4uw	977	28	,	,	,
cord-001835-0s7ok4uw	977	29	i.e.	i.e.	FW
cord-001835-0s7ok4uw	977	30	helices	helix	NNS
cord-001835-0s7ok4uw	977	31	,	,	,
cord-001835-0s7ok4uw	977	32	sheets	sheet	NNS
cord-001835-0s7ok4uw	977	33	and	and	CC
cord-001835-0s7ok4uw	977	34	loops	loop	NNS
cord-001835-0s7ok4uw	977	35	.	.	.
cord-001835-0s7ok4uw	978	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	978	2	have	have	VBP
cord-001835-0s7ok4uw	978	3	,	,	,
cord-001835-0s7ok4uw	978	4	however	however	RB
cord-001835-0s7ok4uw	978	5	,	,	,
cord-001835-0s7ok4uw	978	6	been	be	VBN
cord-001835-0s7ok4uw	978	7	developing	develop	VBG
cord-001835-0s7ok4uw	978	8	an	an	DT
cord-001835-0s7ok4uw	978	9	alternative	alternative	JJ
cord-001835-0s7ok4uw	978	10	and	and	CC
cord-001835-0s7ok4uw	978	11	complementary	complementary	JJ
cord-001835-0s7ok4uw	978	12	paradigm	paradigm	NN
cord-001835-0s7ok4uw	978	13	based	base	VBN
cord-001835-0s7ok4uw	978	14	on	on	IN
cord-001835-0s7ok4uw	978	15	conserved	conserve	VBN
cord-001835-0s7ok4uw	978	16	hydropathic	hydropathic	JJ
cord-001835-0s7ok4uw	978	17	interaction	interaction	NN
cord-001835-0s7ok4uw	978	18	networks	network	NNS
cord-001835-0s7ok4uw	978	19	within	within	IN
cord-001835-0s7ok4uw	978	20	proteins	protein	NNS
cord-001835-0s7ok4uw	978	21	.	.	.
cord-001835-0s7ok4uw	979	1	These	these	DT
cord-001835-0s7ok4uw	979	2	networks	network	NNS
cord-001835-0s7ok4uw	979	3	can	can	MD
cord-001835-0s7ok4uw	979	4	be	be	VB
cord-001835-0s7ok4uw	979	5	viewed	view	VBN
cord-001835-0s7ok4uw	979	6	as	as	IN
cord-001835-0s7ok4uw	979	7	environments	environment	NNS
cord-001835-0s7ok4uw	979	8	comprised	comprise	VBN
cord-001835-0s7ok4uw	979	9	of	of	IN
cord-001835-0s7ok4uw	979	10	a	a	DT
cord-001835-0s7ok4uw	979	11	mixture	mixture	NN
cord-001835-0s7ok4uw	979	12	of	of	IN
cord-001835-0s7ok4uw	979	13	polar	polar	JJ
cord-001835-0s7ok4uw	979	14	and	and	CC
cord-001835-0s7ok4uw	979	15	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	979	16	interaction	interaction	NN
cord-001835-0s7ok4uw	979	17	fields	field	NNS
cord-001835-0s7ok4uw	979	18	,	,	,
cord-001835-0s7ok4uw	979	19	and	and	CC
cord-001835-0s7ok4uw	979	20	may	may	MD
cord-001835-0s7ok4uw	979	21	be	be	VB
cord-001835-0s7ok4uw	979	22	the	the	DT
cord-001835-0s7ok4uw	979	23	most	most	RBS
cord-001835-0s7ok4uw	979	24	important	important	JJ
cord-001835-0s7ok4uw	979	25	factor	factor	NN
cord-001835-0s7ok4uw	979	26	driving	drive	VBG
cord-001835-0s7ok4uw	979	27	protein	protein	NN
cord-001835-0s7ok4uw	979	28	folding	folding	NN
cord-001835-0s7ok4uw	979	29	.	.	.
cord-001835-0s7ok4uw	980	1	This	this	DT
cord-001835-0s7ok4uw	980	2	concept	concept	NN
cord-001835-0s7ok4uw	980	3	applies	apply	VBZ
cord-001835-0s7ok4uw	980	4	even	even	RB
cord-001835-0s7ok4uw	980	5	to	to	IN
cord-001835-0s7ok4uw	980	6	the	the	DT
cord-001835-0s7ok4uw	980	7	lowest	low	JJS
cord-001835-0s7ok4uw	980	8	structural	structural	JJ
cord-001835-0s7ok4uw	980	9	level	level	NN
cord-001835-0s7ok4uw	980	10	within	within	IN
cord-001835-0s7ok4uw	980	11	a	a	DT
cord-001835-0s7ok4uw	980	12	protein	protein	NN
cord-001835-0s7ok4uw	980	13	:	:	:
cord-001835-0s7ok4uw	980	14	the	the	DT
cord-001835-0s7ok4uw	980	15	sidechain	sidechain	NN
cord-001835-0s7ok4uw	980	16	conformations	conformation	NNS
cord-001835-0s7ok4uw	980	17	(	(	-LRB-
cord-001835-0s7ok4uw	980	18	or	or	CC
cord-001835-0s7ok4uw	980	19	rotamers	rotamer	NNS
cord-001835-0s7ok4uw	980	20	)	)	-RRB-
cord-001835-0s7ok4uw	980	21	.	.	.
cord-001835-0s7ok4uw	981	1	Exhaustive	exhaustive	JJ
cord-001835-0s7ok4uw	981	2	statistical	statistical	JJ
cord-001835-0s7ok4uw	981	3	analysis	analysis	NN
cord-001835-0s7ok4uw	981	4	of	of	IN
cord-001835-0s7ok4uw	981	5	existing	exist	VBG
cord-001835-0s7ok4uw	981	6	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	981	7	structures	structure	NNS
cord-001835-0s7ok4uw	981	8	of	of	IN
cord-001835-0s7ok4uw	981	9	proteins	protein	NNS
cord-001835-0s7ok4uw	981	10	showed	show	VBD
cord-001835-0s7ok4uw	981	11	rotameric	rotameric	JJ
cord-001835-0s7ok4uw	981	12	preferences	preference	NNS
cord-001835-0s7ok4uw	981	13	and	and	CC
cord-001835-0s7ok4uw	981	14	led	lead	VBD
cord-001835-0s7ok4uw	981	15	to	to	IN
cord-001835-0s7ok4uw	981	16	the	the	DT
cord-001835-0s7ok4uw	981	17	creation	creation	NN
cord-001835-0s7ok4uw	981	18	of	of	IN
cord-001835-0s7ok4uw	981	19	rotamer	rotamer	NNP
cord-001835-0s7ok4uw	981	20	libraries	library	NNS
cord-001835-0s7ok4uw	981	21	frequently	frequently	RB
cord-001835-0s7ok4uw	981	22	used	use	VBN
cord-001835-0s7ok4uw	981	23	in	in	IN
cord-001835-0s7ok4uw	981	24	multiple	multiple	JJ
cord-001835-0s7ok4uw	981	25	aspects	aspect	NNS
cord-001835-0s7ok4uw	981	26	of	of	IN
cord-001835-0s7ok4uw	981	27	structural	structural	JJ
cord-001835-0s7ok4uw	981	28	biology	biology	NN
cord-001835-0s7ok4uw	981	29	,	,	,
cord-001835-0s7ok4uw	981	30	e.g.	e.g.	RB
cord-001835-0s7ok4uw	981	31	,	,	,
cord-001835-0s7ok4uw	981	32	crystallography	crystallography	NN
cord-001835-0s7ok4uw	981	33	of	of	IN
cord-001835-0s7ok4uw	981	34	relatively	relatively	RB
cord-001835-0s7ok4uw	981	35	low	low	JJ
cord-001835-0s7ok4uw	981	36	-	-	HYPH
cord-001835-0s7ok4uw	981	37	resolution	resolution	NN
cord-001835-0s7ok4uw	981	38	structures	structure	NNS
cord-001835-0s7ok4uw	981	39	,	,	,
cord-001835-0s7ok4uw	981	40	homology	homology	NN
cord-001835-0s7ok4uw	981	41	modeling	model	VBG
cord-001835-0s7ok4uw	981	42	and	and	CC
cord-001835-0s7ok4uw	981	43	biomolecular	biomolecular	JJ
cord-001835-0s7ok4uw	981	44	NMR	nmr	NN
cord-001835-0s7ok4uw	981	45	.	.	.
cord-001835-0s7ok4uw	982	1	However	however	RB
cord-001835-0s7ok4uw	982	2	,	,	,
cord-001835-0s7ok4uw	982	3	little	little	JJ
cord-001835-0s7ok4uw	982	4	is	be	VBZ
cord-001835-0s7ok4uw	982	5	actually	actually	RB
cord-001835-0s7ok4uw	982	6	known	know	VBN
cord-001835-0s7ok4uw	982	7	about	about	IN
cord-001835-0s7ok4uw	982	8	the	the	DT
cord-001835-0s7ok4uw	982	9	forces	force	NNS
cord-001835-0s7ok4uw	982	10	and	and	CC
cord-001835-0s7ok4uw	982	11	factors	factor	NNS
cord-001835-0s7ok4uw	982	12	driving	drive	VBG
cord-001835-0s7ok4uw	982	13	the	the	DT
cord-001835-0s7ok4uw	982	14	preference	preference	NN
cord-001835-0s7ok4uw	982	15	or	or	CC
cord-001835-0s7ok4uw	982	16	suitability	suitability	NN
cord-001835-0s7ok4uw	982	17	of	of	IN
cord-001835-0s7ok4uw	982	18	one	one	CD
cord-001835-0s7ok4uw	982	19	rotamer	rotamer	NN
cord-001835-0s7ok4uw	982	20	over	over	IN
cord-001835-0s7ok4uw	982	21	another	another	DT
cord-001835-0s7ok4uw	982	22	.	.	.
cord-001835-0s7ok4uw	983	1	In	in	IN
cord-001835-0s7ok4uw	983	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	983	3	study	study	NN
cord-001835-0s7ok4uw	983	4	,	,	,
cord-001835-0s7ok4uw	983	5	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	983	6	was	be	VBD
cord-001835-0s7ok4uw	983	7	analyzed	analyze	VBN
cord-001835-0s7ok4uw	983	8	since	since	IN
cord-001835-0s7ok4uw	983	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	983	10	sidechain	sidechain	NN
cord-001835-0s7ok4uw	983	11	has	have	VBZ
cord-001835-0s7ok4uw	983	12	a	a	DT
cord-001835-0s7ok4uw	983	13	comprehensive	comprehensive	JJ
cord-001835-0s7ok4uw	983	14	set	set	NN
cord-001835-0s7ok4uw	983	15	of	of	IN
cord-001835-0s7ok4uw	983	16	hydropathic	hydropathic	JJ
cord-001835-0s7ok4uw	983	17	properties	property	NNS
cord-001835-0s7ok4uw	983	18	that	that	WDT
cord-001835-0s7ok4uw	983	19	made	make	VBD
cord-001835-0s7ok4uw	983	20	it	-PRON-	PRP
cord-001835-0s7ok4uw	983	21	ideal	ideal	JJ
cord-001835-0s7ok4uw	983	22	as	as	IN
cord-001835-0s7ok4uw	983	23	a	a	DT
cord-001835-0s7ok4uw	983	24	proof	proof	NN
cord-001835-0s7ok4uw	983	25	of	of	IN
cord-001835-0s7ok4uw	983	26	concept	concept	NN
cord-001835-0s7ok4uw	983	27	residue	residue	NN
cord-001835-0s7ok4uw	983	28	.	.	.
cord-001835-0s7ok4uw	984	1	Construction	Construction	NNP
cord-001835-0s7ok4uw	984	2	of	of	IN
cord-001835-0s7ok4uw	984	3	3D	3D	NNP
cord-001835-0s7ok4uw	984	4	hydropathic	hydropathic	NNP
cord-001835-0s7ok4uw	984	5	interaction	interaction	NN
cord-001835-0s7ok4uw	984	6	maps	map	NNS
cord-001835-0s7ok4uw	984	7	of	of	IN
cord-001835-0s7ok4uw	984	8	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	984	9	residues	residue	NNS
cord-001835-0s7ok4uw	984	10	in	in	IN
cord-001835-0s7ok4uw	984	11	our	-PRON-	PRP$
cord-001835-0s7ok4uw	984	12	dataset	dataset	NN
cord-001835-0s7ok4uw	984	13	,	,	,
cord-001835-0s7ok4uw	984	14	reveals	reveal	VBZ
cord-001835-0s7ok4uw	984	15	the	the	DT
cord-001835-0s7ok4uw	984	16	environment	environment	NN
cord-001835-0s7ok4uw	984	17	around	around	IN
cord-001835-0s7ok4uw	984	18	each	each	DT
cord-001835-0s7ok4uw	984	19	,	,	,
cord-001835-0s7ok4uw	984	20	in	in	IN
cord-001835-0s7ok4uw	984	21	terms	term	NNS
cord-001835-0s7ok4uw	984	22	of	of	IN
cord-001835-0s7ok4uw	984	23	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	984	24	(	(	-LRB-
cord-001835-0s7ok4uw	984	25	p	p	NN
cord-001835-0s7ok4uw	984	26	-	-	HYPH
cord-001835-0s7ok4uw	984	27	p	p	NN
cord-001835-0s7ok4uw	984	28	stacking	stacking	NN
cord-001835-0s7ok4uw	984	29	,	,	,
cord-001835-0s7ok4uw	984	30	etc	etc	FW
cord-001835-0s7ok4uw	984	31	.	.	.
cord-001835-0s7ok4uw	984	32	)	)	-RRB-
cord-001835-0s7ok4uw	984	33	and	and	CC
cord-001835-0s7ok4uw	984	34	polar	polar	JJ
cord-001835-0s7ok4uw	984	35	(	(	-LRB-
cord-001835-0s7ok4uw	984	36	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	984	37	bonding	bonding	NN
cord-001835-0s7ok4uw	984	38	,	,	,
cord-001835-0s7ok4uw	984	39	etc	etc	FW
cord-001835-0s7ok4uw	984	40	.	.	.
cord-001835-0s7ok4uw	984	41	)	)	-RRB-
cord-001835-0s7ok4uw	985	1	interactions	interaction	NNS
cord-001835-0s7ok4uw	985	2	.	.	.
cord-001835-0s7ok4uw	986	1	After	after	IN
cord-001835-0s7ok4uw	986	2	partitioning	partition	VBG
cord-001835-0s7ok4uw	986	3	the	the	DT
cord-001835-0s7ok4uw	986	4	tyrosines	tyrosine	NNS
cord-001835-0s7ok4uw	986	5	into	into	IN
cord-001835-0s7ok4uw	986	6	backbonedependent	backbonedependent	NN
cord-001835-0s7ok4uw	986	7	bins	bin	NNS
cord-001835-0s7ok4uw	986	8	,	,	,
cord-001835-0s7ok4uw	986	9	a	a	DT
cord-001835-0s7ok4uw	986	10	map	map	NN
cord-001835-0s7ok4uw	986	11	similarity	similarity	NN
cord-001835-0s7ok4uw	986	12	metric	metric	NN
cord-001835-0s7ok4uw	986	13	based	base	VBN
cord-001835-0s7ok4uw	986	14	on	on	IN
cord-001835-0s7ok4uw	986	15	the	the	DT
cord-001835-0s7ok4uw	986	16	correlation	correlation	NN
cord-001835-0s7ok4uw	986	17	coefficient	coefficient	NN
cord-001835-0s7ok4uw	986	18	was	be	VBD
cord-001835-0s7ok4uw	986	19	applied	apply	VBN
cord-001835-0s7ok4uw	986	20	to	to	IN
cord-001835-0s7ok4uw	986	21	each	each	DT
cord-001835-0s7ok4uw	986	22	mapmap	mapmap	NNP
cord-001835-0s7ok4uw	986	23	pair	pair	VBP
cord-001835-0s7ok4uw	986	24	to	to	TO
cord-001835-0s7ok4uw	986	25	build	build	VB
cord-001835-0s7ok4uw	986	26	matrices	matrix	NNS
cord-001835-0s7ok4uw	986	27	suitable	suitable	JJ
cord-001835-0s7ok4uw	986	28	for	for	IN
cord-001835-0s7ok4uw	986	29	clustering	clustering	NN
cord-001835-0s7ok4uw	986	30	.	.	.
cord-001835-0s7ok4uw	987	1	Notably	notably	RB
cord-001835-0s7ok4uw	987	2	,	,	,
cord-001835-0s7ok4uw	987	3	the	the	DT
cord-001835-0s7ok4uw	987	4	first	first	JJ
cord-001835-0s7ok4uw	987	5	bin	bin	NNP
cord-001835-0s7ok4uw	987	6	representing	represent	VBG
cord-001835-0s7ok4uw	987	7	631	631	CD
cord-001835-0s7ok4uw	987	8	tyrosines	tyrosine	NNS
cord-001835-0s7ok4uw	987	9	,	,	,
cord-001835-0s7ok4uw	987	10	reduced	reduce	VBN
cord-001835-0s7ok4uw	987	11	to	to	IN
cord-001835-0s7ok4uw	987	12	14	14	CD
cord-001835-0s7ok4uw	987	13	unique	unique	JJ
cord-001835-0s7ok4uw	987	14	hydropathic	hydropathic	JJ
cord-001835-0s7ok4uw	987	15	environments	environment	NNS
cord-001835-0s7ok4uw	987	16	with	with	IN
cord-001835-0s7ok4uw	987	17	most	most	JJS
cord-001835-0s7ok4uw	987	18	diversity	diversity	NN
cord-001835-0s7ok4uw	987	19	arising	arise	VBG
cord-001835-0s7ok4uw	987	20	from	from	IN
cord-001835-0s7ok4uw	987	21	favorable	favorable	JJ
cord-001835-0s7ok4uw	987	22	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	987	23	interactions	interaction	NNS
cord-001835-0s7ok4uw	987	24	with	with	IN
cord-001835-0s7ok4uw	987	25	many	many	JJ
cord-001835-0s7ok4uw	987	26	different	different	JJ
cord-001835-0s7ok4uw	987	27	residue	residue	NN
cord-001835-0s7ok4uw	987	28	partner	partner	NN
cord-001835-0s7ok4uw	987	29	types	type	NNS
cord-001835-0s7ok4uw	987	30	.	.	.
cord-001835-0s7ok4uw	988	1	Polar	polar	JJ
cord-001835-0s7ok4uw	988	2	interactions	interaction	NNS
cord-001835-0s7ok4uw	988	3	for	for	IN
cord-001835-0s7ok4uw	988	4	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	988	5	include	include	VBP
cord-001835-0s7ok4uw	988	6	ubiquitous	ubiquitous	JJ
cord-001835-0s7ok4uw	988	7	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	988	8	bonding	bonding	NN
cord-001835-0s7ok4uw	988	9	with	with	IN
cord-001835-0s7ok4uw	988	10	the	the	DT
cord-001835-0s7ok4uw	988	11	phenolic	phenolic	JJ
cord-001835-0s7ok4uw	988	12	OH	oh	UH
cord-001835-0s7ok4uw	988	13	and	and	CC
cord-001835-0s7ok4uw	988	14	somewhat	somewhat	RB
cord-001835-0s7ok4uw	988	15	surprisingly	surprisingly	RB
cord-001835-0s7ok4uw	988	16	a	a	DT
cord-001835-0s7ok4uw	988	17	handful	handful	NN
cord-001835-0s7ok4uw	988	18	of	of	IN
cord-001835-0s7ok4uw	988	19	unique	unique	JJ
cord-001835-0s7ok4uw	988	20	environments	environment	NNS
cord-001835-0s7ok4uw	988	21	for	for	IN
cord-001835-0s7ok4uw	988	22	the	the	DT
cord-001835-0s7ok4uw	988	23	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	988	24	backbone	backbone	NN
cord-001835-0s7ok4uw	988	25	.	.	.
cord-001835-0s7ok4uw	989	1	All	all	DT
cord-001835-0s7ok4uw	989	2	but	but	IN
cord-001835-0s7ok4uw	989	3	one	one	CD
cord-001835-0s7ok4uw	989	4	of	of	IN
cord-001835-0s7ok4uw	989	5	the	the	DT
cord-001835-0s7ok4uw	989	6	14	14	CD
cord-001835-0s7ok4uw	989	7	environments	environment	NNS
cord-001835-0s7ok4uw	989	8	are	be	VBP
cord-001835-0s7ok4uw	989	9	dominated	dominate	VBN
cord-001835-0s7ok4uw	989	10	by	by	IN
cord-001835-0s7ok4uw	989	11	a	a	DT
cord-001835-0s7ok4uw	989	12	single	single	JJ
cord-001835-0s7ok4uw	989	13	rotamer	rotamer	NNP
cord-001835-0s7ok4uw	989	14	,	,	,
cord-001835-0s7ok4uw	989	15	the	the	DT
cord-001835-0s7ok4uw	989	16	exception	exception	NN
cord-001835-0s7ok4uw	989	17	being	be	VBG
cord-001835-0s7ok4uw	989	18	an	an	DT
cord-001835-0s7ok4uw	989	19	environment	environment	NN
cord-001835-0s7ok4uw	989	20	defined	define	VBN
cord-001835-0s7ok4uw	989	21	by	by	IN
cord-001835-0s7ok4uw	989	22	a	a	DT
cord-001835-0s7ok4uw	989	23	paucity	paucity	NN
cord-001835-0s7ok4uw	989	24	of	of	IN
cord-001835-0s7ok4uw	989	25	interactions	interaction	NNS
cord-001835-0s7ok4uw	989	26	with	with	IN
cord-001835-0s7ok4uw	989	27	the	the	DT
cord-001835-0s7ok4uw	989	28	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	989	29	ring	ring	NN
cord-001835-0s7ok4uw	989	30	and	and	CC
cord-001835-0s7ok4uw	989	31	as	as	IN
cord-001835-0s7ok4uw	989	32	a	a	DT
cord-001835-0s7ok4uw	989	33	consequence	consequence	NN
cord-001835-0s7ok4uw	989	34	its	-PRON-	PRP$
cord-001835-0s7ok4uw	989	35	rotamer	rotamer	NN
cord-001835-0s7ok4uw	989	36	is	be	VBZ
cord-001835-0s7ok4uw	989	37	indeterminate	indeterminate	JJ
cord-001835-0s7ok4uw	989	38	.	.	.
cord-001835-0s7ok4uw	990	1	This	this	DT
cord-001835-0s7ok4uw	990	2	is	be	VBZ
cord-001835-0s7ok4uw	990	3	consistent	consistent	JJ
cord-001835-0s7ok4uw	990	4	with	with	IN
cord-001835-0s7ok4uw	990	5	it	-PRON-	PRP
cord-001835-0s7ok4uw	990	6	being	be	VBG
cord-001835-0s7ok4uw	990	7	composed	compose	VBN
cord-001835-0s7ok4uw	990	8	of	of	IN
cord-001835-0s7ok4uw	990	9	mostly	mostly	RB
cord-001835-0s7ok4uw	990	10	surface	surface	NN
cord-001835-0s7ok4uw	990	11	residues	residue	NNS
cord-001835-0s7ok4uw	990	12	.	.	.
cord-001835-0s7ok4uw	991	1	Each	each	DT
cord-001835-0s7ok4uw	991	2	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	991	3	residue	residue	NN
cord-001835-0s7ok4uw	991	4	attempts	attempt	NNS
cord-001835-0s7ok4uw	991	5	to	to	TO
cord-001835-0s7ok4uw	991	6	fulfill	fulfill	VB
cord-001835-0s7ok4uw	991	7	its	-PRON-	PRP$
cord-001835-0s7ok4uw	991	8	hydropathic	hydropathic	JJ
cord-001835-0s7ok4uw	991	9	valences	valence	NNS
cord-001835-0s7ok4uw	991	10	and	and	CC
cord-001835-0s7ok4uw	991	11	thus	thus	RB
cord-001835-0s7ok4uw	991	12	,	,	,
cord-001835-0s7ok4uw	991	13	structural	structural	JJ
cord-001835-0s7ok4uw	991	14	water	water	NN
cord-001835-0s7ok4uw	991	15	molecules	molecule	NNS
cord-001835-0s7ok4uw	991	16	are	be	VBP
cord-001835-0s7ok4uw	991	17	seen	see	VBN
cord-001835-0s7ok4uw	991	18	in	in	IN
cord-001835-0s7ok4uw	991	19	a	a	DT
cord-001835-0s7ok4uw	991	20	variety	variety	NN
cord-001835-0s7ok4uw	991	21	of	of	IN
cord-001835-0s7ok4uw	991	22	roles	role	NNS
cord-001835-0s7ok4uw	991	23	throughout	throughout	IN
cord-001835-0s7ok4uw	991	24	these	these	DT
cord-001835-0s7ok4uw	991	25	environments	environment	NNS
cord-001835-0s7ok4uw	991	26	.	.	.
cord-001835-0s7ok4uw	992	1	Alanine	Alanine	NNP
cord-001835-0s7ok4uw	992	2	was	be	VBD
cord-001835-0s7ok4uw	992	3	analyzed	analyze	VBN
cord-001835-0s7ok4uw	992	4	using	use	VBG
cord-001835-0s7ok4uw	992	5	the	the	DT
cord-001835-0s7ok4uw	992	6	same	same	JJ
cord-001835-0s7ok4uw	992	7	protocol	protocol	NN
cord-001835-0s7ok4uw	992	8	as	as	RB
cord-001835-0s7ok4uw	992	9	well	well	RB
cord-001835-0s7ok4uw	992	10	.	.	.
cord-001835-0s7ok4uw	993	1	Having	have	VBG
cord-001835-0s7ok4uw	993	2	the	the	DT
cord-001835-0s7ok4uw	993	3	smallest	small	JJS
cord-001835-0s7ok4uw	993	4	sidechain	sidechain	NN
cord-001835-0s7ok4uw	993	5	(	(	-LRB-
cord-001835-0s7ok4uw	993	6	and	and	CC
cord-001835-0s7ok4uw	993	7	small	small	JJ
cord-001835-0s7ok4uw	993	8	hydropathic	hydropathic	JJ
cord-001835-0s7ok4uw	993	9	interaction	interaction	NN
cord-001835-0s7ok4uw	993	10	maps	map	NNS
cord-001835-0s7ok4uw	993	11	)	)	-RRB-
cord-001835-0s7ok4uw	993	12	,	,	,
cord-001835-0s7ok4uw	993	13	alanine	alanine	NN
cord-001835-0s7ok4uw	993	14	allowed	allow	VBD
cord-001835-0s7ok4uw	993	15	us	-PRON-	PRP
cord-001835-0s7ok4uw	993	16	to	to	TO
cord-001835-0s7ok4uw	993	17	investigate	investigate	VB
cord-001835-0s7ok4uw	993	18	a	a	DT
cord-001835-0s7ok4uw	993	19	significantly	significantly	RB
cord-001835-0s7ok4uw	993	20	larger	large	JJR
cord-001835-0s7ok4uw	993	21	database	database	NN
cord-001835-0s7ok4uw	993	22	,	,	,
cord-001835-0s7ok4uw	993	23	permitting	permit	VBG
cord-001835-0s7ok4uw	993	24	us	-PRON-	PRP
cord-001835-0s7ok4uw	993	25	to	to	TO
cord-001835-0s7ok4uw	993	26	examine	examine	VB
cord-001835-0s7ok4uw	993	27	the	the	DT
cord-001835-0s7ok4uw	993	28	correlation	correlation	NN
cord-001835-0s7ok4uw	993	29	between	between	IN
cord-001835-0s7ok4uw	993	30	hydropathic	hydropathic	NNP
cord-001835-0s7ok4uw	993	31	maps	map	NNS
cord-001835-0s7ok4uw	993	32	and	and	CC
cord-001835-0s7ok4uw	993	33	various	various	JJ
cord-001835-0s7ok4uw	993	34	structural	structural	JJ
cord-001835-0s7ok4uw	993	35	features	feature	NNS
cord-001835-0s7ok4uw	993	36	.	.	.
cord-001835-0s7ok4uw	994	1	In	in	IN
cord-001835-0s7ok4uw	994	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	994	3	,	,	,
cord-001835-0s7ok4uw	994	4	the	the	DT
cord-001835-0s7ok4uw	994	5	analysis	analysis	NN
cord-001835-0s7ok4uw	994	6	of	of	IN
cord-001835-0s7ok4uw	994	7	hydropathic	hydropathic	JJ
cord-001835-0s7ok4uw	994	8	environments	environment	NNS
cord-001835-0s7ok4uw	994	9	strongly	strongly	RB
cord-001835-0s7ok4uw	994	10	suggests	suggest	VBZ
cord-001835-0s7ok4uw	994	11	that	that	IN
cord-001835-0s7ok4uw	994	12	the	the	DT
cord-001835-0s7ok4uw	994	13	orientation	orientation	NN
cord-001835-0s7ok4uw	994	14	of	of	IN
cord-001835-0s7ok4uw	994	15	a	a	DT
cord-001835-0s7ok4uw	994	16	residue	residue	NN
cord-001835-0s7ok4uw	994	17	in	in	IN
cord-001835-0s7ok4uw	994	18	a	a	DT
cord-001835-0s7ok4uw	994	19	three	three	CD
cord-001835-0s7ok4uw	994	20	-	-	HYPH
cord-001835-0s7ok4uw	994	21	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	994	22	structure	structure	NN
cord-001835-0s7ok4uw	994	23	is	be	VBZ
cord-001835-0s7ok4uw	994	24	a	a	DT
cord-001835-0s7ok4uw	994	25	direct	direct	JJ
cord-001835-0s7ok4uw	994	26	consequence	consequence	NN
cord-001835-0s7ok4uw	994	27	of	of	IN
cord-001835-0s7ok4uw	994	28	its	-PRON-	PRP$
cord-001835-0s7ok4uw	994	29	hydropathic	hydropathic	JJ
cord-001835-0s7ok4uw	994	30	environment	environment	NN
cord-001835-0s7ok4uw	994	31	,	,	,
cord-001835-0s7ok4uw	994	32	which	which	WDT
cord-001835-0s7ok4uw	994	33	leads	lead	VBZ
cord-001835-0s7ok4uw	994	34	us	-PRON-	PRP
cord-001835-0s7ok4uw	994	35	to	to	TO
cord-001835-0s7ok4uw	994	36	propose	propose	VB
cord-001835-0s7ok4uw	994	37	a	a	DT
cord-001835-0s7ok4uw	994	38	new	new	JJ
cord-001835-0s7ok4uw	994	39	paradigm	paradigm	NN
cord-001835-0s7ok4uw	994	40	,	,	,
cord-001835-0s7ok4uw	994	41	interaction	interaction	NN
cord-001835-0s7ok4uw	994	42	homology	homology	NN
cord-001835-0s7ok4uw	994	43	,	,	,
cord-001835-0s7ok4uw	994	44	as	as	IN
cord-001835-0s7ok4uw	994	45	a	a	DT
cord-001835-0s7ok4uw	994	46	key	key	JJ
cord-001835-0s7ok4uw	994	47	factor	factor	NN
cord-001835-0s7ok4uw	994	48	in	in	IN
cord-001835-0s7ok4uw	994	49	protein	protein	NN
cord-001835-0s7ok4uw	994	50	structure	structure	NN
cord-001835-0s7ok4uw	994	51	.	.	.
cord-001835-0s7ok4uw	995	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	995	2	is	be	VBZ
cord-001835-0s7ok4uw	995	3	not	not	RB
cord-001835-0s7ok4uw	995	4	the	the	DT
cord-001835-0s7ok4uw	995	5	surrounding	surround	VBG
cord-001835-0s7ok4uw	995	6	residues	residue	NNS
cord-001835-0s7ok4uw	995	7	that	that	WDT
cord-001835-0s7ok4uw	995	8	direct	direct	JJ
cord-001835-0s7ok4uw	995	9	sidechain	sidechain	NN
cord-001835-0s7ok4uw	995	10	conformations	conformation	NNS
cord-001835-0s7ok4uw	995	11	,	,	,
cord-001835-0s7ok4uw	995	12	but	but	CC
cord-001835-0s7ok4uw	995	13	rather	rather	RB
cord-001835-0s7ok4uw	995	14	the	the	DT
cord-001835-0s7ok4uw	995	15	hydropathic	hydropathic	JJ
cord-001835-0s7ok4uw	995	16	"	"	``
cord-001835-0s7ok4uw	995	17	field	field	NN
cord-001835-0s7ok4uw	995	18	"	"	''
cord-001835-0s7ok4uw	995	19	of	of	IN
cord-001835-0s7ok4uw	995	20	the	the	DT
cord-001835-0s7ok4uw	995	21	surrounding	surround	VBG
cord-001835-0s7ok4uw	995	22	atoms	atom	NNS
cord-001835-0s7ok4uw	995	23	.	.	.
cord-001835-0s7ok4uw	996	1	Folding	folding	NN
cord-001835-0s7ok4uw	996	2	studies	study	NNS
cord-001835-0s7ok4uw	996	3	of	of	IN
cord-001835-0s7ok4uw	996	4	independent	independent	JJ
cord-001835-0s7ok4uw	996	5	domains	domain	NNS
cord-001835-0s7ok4uw	996	6	of	of	IN
cord-001835-0s7ok4uw	996	7	Lysine	lysine	NN
cord-001835-0s7ok4uw	996	8	,	,	,
cord-001835-0s7ok4uw	996	9	Arginine	Arginine	NNP
cord-001835-0s7ok4uw	996	10	,	,	,
cord-001835-0s7ok4uw	996	11	Ornithine	Ornithine	NNP
cord-001835-0s7ok4uw	996	12	binding	bind	VBG
cord-001835-0s7ok4uw	996	13	protein	protein	NN
cord-001835-0s7ok4uw	996	14	(	(	-LRB-
cord-001835-0s7ok4uw	996	15	LAO	LAO	NNP
cord-001835-0s7ok4uw	996	16	)	)	-RRB-
cord-001835-0s7ok4uw	996	17	Protein	protein	NN
cord-001835-0s7ok4uw	996	18	folding	folding	NN
cord-001835-0s7ok4uw	996	19	problem	problem	NN
cord-001835-0s7ok4uw	996	20	has	have	VBZ
cord-001835-0s7ok4uw	996	21	been	be	VBN
cord-001835-0s7ok4uw	996	22	addressed	address	VBN
cord-001835-0s7ok4uw	996	23	from	from	IN
cord-001835-0s7ok4uw	996	24	the	the	DT
cord-001835-0s7ok4uw	996	25	past	past	JJ
cord-001835-0s7ok4uw	996	26	50	50	CD
cord-001835-0s7ok4uw	996	27	years	year	NNS
cord-001835-0s7ok4uw	996	28	until	until	IN
cord-001835-0s7ok4uw	996	29	nowadays	nowadays	RB
cord-001835-0s7ok4uw	996	30	,	,	,
cord-001835-0s7ok4uw	996	31	however	however	RB
cord-001835-0s7ok4uw	996	32	,	,	,
cord-001835-0s7ok4uw	996	33	we	-PRON-	PRP
cord-001835-0s7ok4uw	996	34	still	still	RB
cord-001835-0s7ok4uw	996	35	can	can	MD
cord-001835-0s7ok4uw	996	36	not	not	RB
cord-001835-0s7ok4uw	996	37	explain	explain	VB
cord-001835-0s7ok4uw	996	38	how	how	WRB
cord-001835-0s7ok4uw	996	39	proteins	protein	NNS
cord-001835-0s7ok4uw	996	40	acquire	acquire	VBP
cord-001835-0s7ok4uw	996	41	their	-PRON-	PRP$
cord-001835-0s7ok4uw	996	42	native	native	JJ
cord-001835-0s7ok4uw	996	43	structure	structure	NN
cord-001835-0s7ok4uw	996	44	from	from	IN
cord-001835-0s7ok4uw	996	45	their	-PRON-	PRP$
cord-001835-0s7ok4uw	996	46	amino	amino	NN
cord-001835-0s7ok4uw	996	47	acid	acid	NN
cord-001835-0s7ok4uw	996	48	sequence	sequence	NN
cord-001835-0s7ok4uw	996	49	.	.	.
cord-001835-0s7ok4uw	997	1	Different	different	JJ
cord-001835-0s7ok4uw	997	2	approaches	approach	NNS
cord-001835-0s7ok4uw	997	3	has	have	VBZ
cord-001835-0s7ok4uw	997	4	been	be	VBN
cord-001835-0s7ok4uw	997	5	taken	take	VBN
cord-001835-0s7ok4uw	997	6	in	in	IN
cord-001835-0s7ok4uw	997	7	order	order	NN
cord-001835-0s7ok4uw	997	8	to	to	TO
cord-001835-0s7ok4uw	997	9	study	study	VB
cord-001835-0s7ok4uw	997	10	protein	protein	NN
cord-001835-0s7ok4uw	997	11	folding	folding	NN
cord-001835-0s7ok4uw	997	12	,	,	,
cord-001835-0s7ok4uw	997	13	for	for	IN
cord-001835-0s7ok4uw	997	14	example	example	NN
cord-001835-0s7ok4uw	997	15	,	,	,
cord-001835-0s7ok4uw	997	16	the	the	DT
cord-001835-0s7ok4uw	997	17	comparative	comparative	JJ
cord-001835-0s7ok4uw	997	18	study	study	NN
cord-001835-0s7ok4uw	997	19	of	of	IN
cord-001835-0s7ok4uw	997	20	folding	fold	VBG
cord-001835-0s7ok4uw	997	21	mechanism	mechanism	NN
cord-001835-0s7ok4uw	997	22	between	between	IN
cord-001835-0s7ok4uw	997	23	homologues	homologue	NNS
cord-001835-0s7ok4uw	997	24	proteins	protein	NNS
cord-001835-0s7ok4uw	997	25	with	with	IN
cord-001835-0s7ok4uw	997	26	high	high	JJ
cord-001835-0s7ok4uw	997	27	identity	identity	NN
cord-001835-0s7ok4uw	997	28	of	of	IN
cord-001835-0s7ok4uw	997	29	sequence	sequence	NN
cord-001835-0s7ok4uw	997	30	and	and	CC
cord-001835-0s7ok4uw	997	31	structure	structure	NN
cord-001835-0s7ok4uw	997	32	,	,	,
cord-001835-0s7ok4uw	997	33	and	and	CC
cord-001835-0s7ok4uw	997	34	the	the	DT
cord-001835-0s7ok4uw	997	35	study	study	NN
cord-001835-0s7ok4uw	997	36	of	of	IN
cord-001835-0s7ok4uw	997	37	independent	independent	JJ
cord-001835-0s7ok4uw	997	38	regions	region	NNS
cord-001835-0s7ok4uw	997	39	within	within	IN
cord-001835-0s7ok4uw	997	40	a	a	DT
cord-001835-0s7ok4uw	997	41	single	single	JJ
cord-001835-0s7ok4uw	997	42	protein	protein	NN
cord-001835-0s7ok4uw	997	43	.	.	.
cord-001835-0s7ok4uw	998	1	Previously	previously	RB
cord-001835-0s7ok4uw	998	2	in	in	IN
cord-001835-0s7ok4uw	998	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	998	4	laboratory	laboratory	NN
cord-001835-0s7ok4uw	998	5	,	,	,
cord-001835-0s7ok4uw	998	6	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	998	7	and	and	CC
cord-001835-0s7ok4uw	998	8	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	998	9	folding	folding	NN
cord-001835-0s7ok4uw	998	10	properties	property	NNS
cord-001835-0s7ok4uw	998	11	of	of	IN
cord-001835-0s7ok4uw	998	12	lysine	lysine	NN
cord-001835-0s7ok4uw	998	13	,	,	,
cord-001835-0s7ok4uw	998	14	ornithine	ornithine	NN
cord-001835-0s7ok4uw	998	15	,	,	,
cord-001835-0s7ok4uw	998	16	arginine	arginine	NN
cord-001835-0s7ok4uw	998	17	binding	bind	VBG
cord-001835-0s7ok4uw	998	18	protein	protein	NN
cord-001835-0s7ok4uw	998	19	(	(	-LRB-
cord-001835-0s7ok4uw	998	20	LAO	LAO	NNP
cord-001835-0s7ok4uw	998	21	)	)	-RRB-
cord-001835-0s7ok4uw	998	22	,	,	,
cord-001835-0s7ok4uw	998	23	a	a	DT
cord-001835-0s7ok4uw	998	24	238	238	CD
cord-001835-0s7ok4uw	998	25	amino	amino	NN
cord-001835-0s7ok4uw	998	26	acid	acid	NN
cord-001835-0s7ok4uw	998	27	periplasmic	periplasmic	JJ
cord-001835-0s7ok4uw	998	28	binding	bind	VBG
cord-001835-0s7ok4uw	998	29	protein	protein	NN
cord-001835-0s7ok4uw	998	30	(	(	-LRB-
cord-001835-0s7ok4uw	998	31	PBP	PBP	NNP
cord-001835-0s7ok4uw	998	32	)	)	-RRB-
cord-001835-0s7ok4uw	998	33	,	,	,
cord-001835-0s7ok4uw	998	34	composed	compose	VBN
cord-001835-0s7ok4uw	998	35	by	by	IN
cord-001835-0s7ok4uw	998	36	two	two	CD
cord-001835-0s7ok4uw	998	37	Rossmann	Rossmann	NNP
cord-001835-0s7ok4uw	998	38	fold	fold	NN
cord-001835-0s7ok4uw	998	39	domains	domain	NNS
cord-001835-0s7ok4uw	998	40	(	(	-LRB-
cord-001835-0s7ok4uw	998	41	one	one	CD
cord-001835-0s7ok4uw	998	42	continuous	continuous	JJ
cord-001835-0s7ok4uw	998	43	and	and	CC
cord-001835-0s7ok4uw	998	44	the	the	DT
cord-001835-0s7ok4uw	998	45	other	other	JJ
cord-001835-0s7ok4uw	998	46	discontinuous	discontinuous	JJ
cord-001835-0s7ok4uw	998	47	)	)	-RRB-
cord-001835-0s7ok4uw	998	48	attached	attach	VBN
cord-001835-0s7ok4uw	998	49	by	by	IN
cord-001835-0s7ok4uw	998	50	a	a	DT
cord-001835-0s7ok4uw	998	51	hinge	hinge	NN
cord-001835-0s7ok4uw	998	52	region	region	NN
cord-001835-0s7ok4uw	998	53	,	,	,
cord-001835-0s7ok4uw	998	54	has	have	VBZ
cord-001835-0s7ok4uw	998	55	been	be	VBN
cord-001835-0s7ok4uw	998	56	studied	study	VBN
cord-001835-0s7ok4uw	998	57	.	.	.
cord-001835-0s7ok4uw	999	1	Even	even	RB
cord-001835-0s7ok4uw	999	2	there	there	EX
cord-001835-0s7ok4uw	999	3	is	be	VBZ
cord-001835-0s7ok4uw	999	4	a	a	DT
cord-001835-0s7ok4uw	999	5	functional	functional	JJ
cord-001835-0s7ok4uw	999	6	research	research	NN
cord-001835-0s7ok4uw	999	7	about	about	IN
cord-001835-0s7ok4uw	999	8	binding	bind	VBG
cord-001835-0s7ok4uw	999	9	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	999	10	of	of	IN
cord-001835-0s7ok4uw	999	11	histidine	histidine	NN
cord-001835-0s7ok4uw	999	12	binding	bind	VBG
cord-001835-0s7ok4uw	999	13	protei	protei	NNP
cord-001835-0s7ok4uw	999	14	ns	ns	IN
cord-001835-0s7ok4uw	999	15	(	(	-LRB-
cord-001835-0s7ok4uw	999	16	His	-PRON-	PRP$
cord-001835-0s7ok4uw	999	17	J	J	NNP
cord-001835-0s7ok4uw	999	18	)	)	-RRB-
cord-001835-0s7ok4uw	999	19	domains	domain	NNS
cord-001835-0s7ok4uw	999	20	of	of	IN
cord-001835-0s7ok4uw	999	21	when	when	WRB
cord-001835-0s7ok4uw	999	22	expressed	express	VBN
cord-001835-0s7ok4uw	999	23	independently	independently	RB
cord-001835-0s7ok4uw	999	24	(	(	-LRB-
cord-001835-0s7ok4uw	999	25	Chu	Chu	NNP
cord-001835-0s7ok4uw	999	26	,	,	,
cord-001835-0s7ok4uw	999	27	B.	B.	NNP
cord-001835-0s7ok4uw	999	28	2013	2013	CD
cord-001835-0s7ok4uw	999	29	)	)	-RRB-
cord-001835-0s7ok4uw	999	30	;	;	:
cord-001835-0s7ok4uw	999	31	there	there	EX
cord-001835-0s7ok4uw	999	32	are	be	VBP
cord-001835-0s7ok4uw	999	33	no	no	DT
cord-001835-0s7ok4uw	999	34	folding	fold	VBG
cord-001835-0s7ok4uw	999	35	studies	study	NNS
cord-001835-0s7ok4uw	999	36	in	in	IN
cord-001835-0s7ok4uw	999	37	these	these	DT
cord-001835-0s7ok4uw	999	38	conditions	condition	NNS
cord-001835-0s7ok4uw	999	39	for	for	IN
cord-001835-0s7ok4uw	999	40	this	this	DT
cord-001835-0s7ok4uw	999	41	or	or	CC
cord-001835-0s7ok4uw	999	42	another	another	DT
cord-001835-0s7ok4uw	999	43	PBPs	pbps	NN
cord-001835-0s7ok4uw	999	44	.	.	.
cord-001835-0s7ok4uw	1000	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1000	2	should	should	MD
cord-001835-0s7ok4uw	1000	3	be	be	VB
cord-001835-0s7ok4uw	1000	4	noted	note	VBN
cord-001835-0s7ok4uw	1000	5	that	that	IN
cord-001835-0s7ok4uw	1000	6	His	-PRON-	PRP$
cord-001835-0s7ok4uw	1000	7	J	J	NNP
cord-001835-0s7ok4uw	1000	8	shares	share	VBZ
cord-001835-0s7ok4uw	1000	9	70	70	CD
cord-001835-0s7ok4uw	1000	10	%	%	NN
cord-001835-0s7ok4uw	1000	11	of	of	IN
cord-001835-0s7ok4uw	1000	12	sequence	sequence	NN
cord-001835-0s7ok4uw	1000	13	identity	identity	NN
cord-001835-0s7ok4uw	1000	14	and	and	CC
cord-001835-0s7ok4uw	1000	15	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	1000	16	structure	structure	NN
cord-001835-0s7ok4uw	1000	17	(	(	-LRB-
cord-001835-0s7ok4uw	1000	18	RMSD	RMSD	NNP
cord-001835-0s7ok4uw	1000	19	1Å	1å	CD
cord-001835-0s7ok4uw	1000	20	)	)	-RRB-
cord-001835-0s7ok4uw	1000	21	with	with	IN
cord-001835-0s7ok4uw	1000	22	LAO	LAO	NNP
cord-001835-0s7ok4uw	1000	23	.	.	.
cord-001835-0s7ok4uw	1001	1	In	in	IN
cord-001835-0s7ok4uw	1001	2	order	order	NN
cord-001835-0s7ok4uw	1001	3	to	to	TO
cord-001835-0s7ok4uw	1001	4	know	know	VB
cord-001835-0s7ok4uw	1001	5	the	the	DT
cord-001835-0s7ok4uw	1001	6	folding	folding	NN
cord-001835-0s7ok4uw	1001	7	effect	effect	NN
cord-001835-0s7ok4uw	1001	8	of	of	IN
cord-001835-0s7ok4uw	1001	9	encoding	encode	VBG
cord-001835-0s7ok4uw	1001	10	different	different	JJ
cord-001835-0s7ok4uw	1001	11	domains	domain	NNS
cord-001835-0s7ok4uw	1001	12	in	in	IN
cord-001835-0s7ok4uw	1001	13	the	the	DT
cord-001835-0s7ok4uw	1001	14	same	same	JJ
cord-001835-0s7ok4uw	1001	15	poly	poly	NNP
cord-001835-0s7ok4uw	1001	16	peptidic	peptidic	NNP
cord-001835-0s7ok4uw	1001	17	chain	chain	NN
cord-001835-0s7ok4uw	1001	18	,	,	,
cord-001835-0s7ok4uw	1001	19	as	as	RB
cord-001835-0s7ok4uw	1001	20	well	well	RB
cord-001835-0s7ok4uw	1001	21	as	as	IN
cord-001835-0s7ok4uw	1001	22	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1001	23	influence	influence	NN
cord-001835-0s7ok4uw	1001	24	in	in	IN
cord-001835-0s7ok4uw	1001	25	function	function	NN
cord-001835-0s7ok4uw	1001	26	,	,	,
cord-001835-0s7ok4uw	1001	27	we	-PRON-	PRP
cord-001835-0s7ok4uw	1001	28	are	be	VBP
cord-001835-0s7ok4uw	1001	29	studying	study	VBG
cord-001835-0s7ok4uw	1001	30	the	the	DT
cord-001835-0s7ok4uw	1001	31	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1001	32	and	and	CC
cord-001835-0s7ok4uw	1001	33	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1001	34	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	1001	35	of	of	IN
cord-001835-0s7ok4uw	1001	36	folding	folding	NN
cord-001835-0s7ok4uw	1001	37	of	of	IN
cord-001835-0s7ok4uw	1001	38	independently	independently	RB
cord-001835-0s7ok4uw	1001	39	expressed	express	VBN
cord-001835-0s7ok4uw	1001	40	lobes	lobe	NNS
cord-001835-0s7ok4uw	1001	41	of	of	IN
cord-001835-0s7ok4uw	1001	42	LAO	LAO	NNP
cord-001835-0s7ok4uw	1001	43	,	,	,
cord-001835-0s7ok4uw	1001	44	and	and	CC
cord-001835-0s7ok4uw	1001	45	comparing	compare	VBG
cord-001835-0s7ok4uw	1001	46	with	with	IN
cord-001835-0s7ok4uw	1001	47	those	those	DT
cord-001835-0s7ok4uw	1001	48	of	of	IN
cord-001835-0s7ok4uw	1001	49	native	native	JJ
cord-001835-0s7ok4uw	1001	50	protein	protein	NN
cord-001835-0s7ok4uw	1001	51	.	.	.
cord-001835-0s7ok4uw	1002	1	By	by	IN
cord-001835-0s7ok4uw	1002	2	now	now	RB
cord-001835-0s7ok4uw	1002	3	,	,	,
cord-001835-0s7ok4uw	1002	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	1002	5	expressed	express	VBD
cord-001835-0s7ok4uw	1002	6	and	and	CC
cord-001835-0s7ok4uw	1002	7	purified	purify	VBD
cord-001835-0s7ok4uw	1002	8	the	the	DT
cord-001835-0s7ok4uw	1002	9	discontinuous	discontinuous	JJ
cord-001835-0s7ok4uw	1002	10	domain	domain	NN
cord-001835-0s7ok4uw	1002	11	.	.	.
cord-001835-0s7ok4uw	1003	1	Circular	circular	JJ
cord-001835-0s7ok4uw	1003	2	dichroism	dichroism	NN
cord-001835-0s7ok4uw	1003	3	(	(	-LRB-
cord-001835-0s7ok4uw	1003	4	CD	cd	NN
cord-001835-0s7ok4uw	1003	5	)	)	-RRB-
cord-001835-0s7ok4uw	1003	6	and	and	CC
cord-001835-0s7ok4uw	1003	7	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1003	8	intensity	intensity	NN
cord-001835-0s7ok4uw	1003	9	spectra	spectrum	NNS
cord-001835-0s7ok4uw	1003	10	show	show	VBP
cord-001835-0s7ok4uw	1003	11	that	that	IN
cord-001835-0s7ok4uw	1003	12	this	this	DT
cord-001835-0s7ok4uw	1003	13	independent	independent	JJ
cord-001835-0s7ok4uw	1003	14	domain	domain	NN
cord-001835-0s7ok4uw	1003	15	has	have	VBZ
cord-001835-0s7ok4uw	1003	16	primary	primary	JJ
cord-001835-0s7ok4uw	1003	17	and	and	CC
cord-001835-0s7ok4uw	1003	18	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	1003	19	structure	structure	NN
cord-001835-0s7ok4uw	1003	20	.	.	.
cord-001835-0s7ok4uw	1004	1	Thermal	thermal	JJ
cord-001835-0s7ok4uw	1004	2	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1004	3	has	have	VBZ
cord-001835-0s7ok4uw	1004	4	a	a	DT
cord-001835-0s7ok4uw	1004	5	single	single	JJ
cord-001835-0s7ok4uw	1004	6	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	1004	7	transition	transition	NN
cord-001835-0s7ok4uw	1004	8	,	,	,
cord-001835-0s7ok4uw	1004	9	which	which	WDT
cord-001835-0s7ok4uw	1004	10	indicates	indicate	VBZ
cord-001835-0s7ok4uw	1004	11	this	this	DT
cord-001835-0s7ok4uw	1004	12	domain	domain	NN
cord-001835-0s7ok4uw	1004	13	is	be	VBZ
cord-001835-0s7ok4uw	1004	14	folded	fold	VBN
cord-001835-0s7ok4uw	1004	15	.	.	.
cord-001835-0s7ok4uw	1005	1	Thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1005	2	analysis	analysis	NN
cord-001835-0s7ok4uw	1005	3	of	of	IN
cord-001835-0s7ok4uw	1005	4	temperature	temperature	NN
cord-001835-0s7ok4uw	1005	5	and	and	CC
cord-001835-0s7ok4uw	1005	6	urea	urea	NN
cord-001835-0s7ok4uw	1005	7	-	-	HYPH
cord-001835-0s7ok4uw	1005	8	induced	induce	VBN
cord-001835-0s7ok4uw	1005	9	experiments	experiment	NNS
cord-001835-0s7ok4uw	1005	10	suggest	suggest	VBP
cord-001835-0s7ok4uw	1005	11	that	that	IN
cord-001835-0s7ok4uw	1005	12	LAO	LAO	NNP
cord-001835-0s7ok4uw	1005	13	's	's	POS
cord-001835-0s7ok4uw	1005	14	folding	folding	NN
cord-001835-0s7ok4uw	1005	15	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	1005	16	are	be	VBP
cord-001835-0s7ok4uw	1005	17	not	not	RB
cord-001835-0s7ok4uw	1005	18	just	just	RB
cord-001835-0s7ok4uw	1005	19	the	the	DT
cord-001835-0s7ok4uw	1005	20	addition	addition	NN
cord-001835-0s7ok4uw	1005	21	of	of	IN
cord-001835-0s7ok4uw	1005	22	those	those	DT
cord-001835-0s7ok4uw	1005	23	from	from	IN
cord-001835-0s7ok4uw	1005	24	independent	independent	JJ
cord-001835-0s7ok4uw	1005	25	domains	domain	NNS
cord-001835-0s7ok4uw	1005	26	.	.	.
cord-001835-0s7ok4uw	1006	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1006	2	,	,	,
cord-001835-0s7ok4uw	1006	3	folding	fold	VBG
cord-001835-0s7ok4uw	1006	4	and	and	CC
cord-001835-0s7ok4uw	1006	5	refolding	refolde	VBG
cord-001835-0s7ok4uw	1006	6	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	1006	7	suggest	suggest	VBP
cord-001835-0s7ok4uw	1006	8	the	the	DT
cord-001835-0s7ok4uw	1006	9	presence	presence	NN
cord-001835-0s7ok4uw	1006	10	of	of	IN
cord-001835-0s7ok4uw	1006	11	a	a	DT
cord-001835-0s7ok4uw	1006	12	burst	burst	NN
cord-001835-0s7ok4uw	1006	13	phase	phase	NN
cord-001835-0s7ok4uw	1006	14	intermediate	intermediate	JJ
cord-001835-0s7ok4uw	1006	15	.	.	.
cord-001835-0s7ok4uw	1007	1	A	a	DT
cord-001835-0s7ok4uw	1007	2	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	1007	3	to	to	TO
cord-001835-0s7ok4uw	1007	4	reconcile	reconcile	VB
cord-001835-0s7ok4uw	1007	5	the	the	DT
cord-001835-0s7ok4uw	1007	6	physical	physical	JJ
cord-001835-0s7ok4uw	1007	7	and	and	CC
cord-001835-0s7ok4uw	1007	8	chemical	chemical	JJ
cord-001835-0s7ok4uw	1007	9	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1007	10	of	of	IN
cord-001835-0s7ok4uw	1007	11	proteins	protein	NNS
cord-001835-0s7ok4uw	1008	1	A	a	DT
cord-001835-0s7ok4uw	1008	2	comprehensive	comprehensive	JJ
cord-001835-0s7ok4uw	1008	3	view	view	NN
cord-001835-0s7ok4uw	1008	4	of	of	IN
cord-001835-0s7ok4uw	1008	5	protein	protein	NN
cord-001835-0s7ok4uw	1008	6	folding	folding	NN
cord-001835-0s7ok4uw	1008	7	is	be	VBZ
cord-001835-0s7ok4uw	1008	8	crucial	crucial	JJ
cord-001835-0s7ok4uw	1008	9	for	for	IN
cord-001835-0s7ok4uw	1008	10	understanding	understanding	NN
cord-001835-0s7ok4uw	1008	11	how	how	WRB
cord-001835-0s7ok4uw	1008	12	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	1008	13	can	can	MD
cord-001835-0s7ok4uw	1008	14	cause	cause	VB
cord-001835-0s7ok4uw	1008	15	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	1008	16	diseases	disease	NNS
cord-001835-0s7ok4uw	1008	17	and	and	CC
cord-001835-0s7ok4uw	1008	18	cancer	cancer	NN
cord-001835-0s7ok4uw	1008	19	.	.	.
cord-001835-0s7ok4uw	1009	1	When	when	WRB
cord-001835-0s7ok4uw	1009	2	using	use	VBG
cord-001835-0s7ok4uw	1009	3	physical	physical	JJ
cord-001835-0s7ok4uw	1009	4	or	or	CC
cord-001835-0s7ok4uw	1009	5	chemical	chemical	JJ
cord-001835-0s7ok4uw	1009	6	perturbations	perturbation	NNS
cord-001835-0s7ok4uw	1009	7	,	,	,
cord-001835-0s7ok4uw	1009	8	NMR	NMR	NNP
cord-001835-0s7ok4uw	1009	9	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1009	10	is	be	VBZ
cord-001835-0s7ok4uw	1009	11	a	a	DT
cord-001835-0s7ok4uw	1009	12	powerful	powerful	JJ
cord-001835-0s7ok4uw	1009	13	tool	tool	NN
cord-001835-0s7ok4uw	1009	14	to	to	TO
cord-001835-0s7ok4uw	1009	15	reveal	reveal	VB
cord-001835-0s7ok4uw	1009	16	a	a	DT
cord-001835-0s7ok4uw	1009	17	shift	shift	NN
cord-001835-0s7ok4uw	1009	18	in	in	IN
cord-001835-0s7ok4uw	1009	19	the	the	DT
cord-001835-0s7ok4uw	1009	20	native	native	JJ
cord-001835-0s7ok4uw	1009	21	conformation	conformation	NN
cord-001835-0s7ok4uw	1009	22	toward	toward	IN
cord-001835-0s7ok4uw	1009	23	local	local	JJ
cord-001835-0s7ok4uw	1009	24	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	1009	25	that	that	WDT
cord-001835-0s7ok4uw	1009	26	act	act	VBP
cord-001835-0s7ok4uw	1009	27	as	as	IN
cord-001835-0s7ok4uw	1009	28	seeds	seed	NNS
cord-001835-0s7ok4uw	1009	29	for	for	IN
cord-001835-0s7ok4uw	1009	30	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	1009	31	.	.	.
cord-001835-0s7ok4uw	1010	1	High	high	JJ
cord-001835-0s7ok4uw	1010	2	pressure	pressure	NN
cord-001835-0s7ok4uw	1010	3	(	(	-LRB-
cord-001835-0s7ok4uw	1010	4	HP	HP	NNP
cord-001835-0s7ok4uw	1010	5	)	)	-RRB-
cord-001835-0s7ok4uw	1010	6	or	or	CC
cord-001835-0s7ok4uw	1010	7	urea	urea	NN
cord-001835-0s7ok4uw	1010	8	is	be	VBZ
cord-001835-0s7ok4uw	1010	9	commonly	commonly	RB
cord-001835-0s7ok4uw	1010	10	used	use	VBN
cord-001835-0s7ok4uw	1010	11	to	to	TO
cord-001835-0s7ok4uw	1010	12	disturb	disturb	VB
cord-001835-0s7ok4uw	1010	13	folding	fold	VBG
cord-001835-0s7ok4uw	1010	14	species	specie	NNS
cord-001835-0s7ok4uw	1010	15	.	.	.
cord-001835-0s7ok4uw	1011	1	Pressure	pressure	NN
cord-001835-0s7ok4uw	1011	2	favors	favor	VBZ
cord-001835-0s7ok4uw	1011	3	the	the	DT
cord-001835-0s7ok4uw	1011	4	reversible	reversible	JJ
cord-001835-0s7ok4uw	1011	5	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1011	6	of	of	IN
cord-001835-0s7ok4uw	1011	7	proteins	protein	NNS
cord-001835-0s7ok4uw	1011	8	by	by	IN
cord-001835-0s7ok4uw	1011	9	causing	cause	VBG
cord-001835-0s7ok4uw	1011	10	changes	change	NNS
cord-001835-0s7ok4uw	1011	11	in	in	IN
cord-001835-0s7ok4uw	1011	12	the	the	DT
cord-001835-0s7ok4uw	1011	13	volumetric	volumetric	JJ
cord-001835-0s7ok4uw	1011	14	properties	property	NNS
cord-001835-0s7ok4uw	1011	15	of	of	IN
cord-001835-0s7ok4uw	1011	16	the	the	DT
cord-001835-0s7ok4uw	1011	17	proteinsolvent	proteinsolvent	NN
cord-001835-0s7ok4uw	1011	18	system	system	NN
cord-001835-0s7ok4uw	1011	19	.	.	.
cord-001835-0s7ok4uw	1012	1	However	however	RB
cord-001835-0s7ok4uw	1012	2	,	,	,
cord-001835-0s7ok4uw	1012	3	no	no	DT
cord-001835-0s7ok4uw	1012	4	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	1012	5	model	model	NN
cord-001835-0s7ok4uw	1012	6	has	have	VBZ
cord-001835-0s7ok4uw	1012	7	fully	fully	RB
cord-001835-0s7ok4uw	1012	8	elucidated	elucidate	VBN
cord-001835-0s7ok4uw	1012	9	the	the	DT
cord-001835-0s7ok4uw	1012	10	effects	effect	NNS
cord-001835-0s7ok4uw	1012	11	of	of	IN
cord-001835-0s7ok4uw	1012	12	urea	urea	NN
cord-001835-0s7ok4uw	1012	13	on	on	IN
cord-001835-0s7ok4uw	1012	14	structure	structure	NN
cord-001835-0s7ok4uw	1012	15	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1012	16	,	,	,
cord-001835-0s7ok4uw	1012	17	even	even	RB
cord-001835-0s7ok4uw	1012	18	though	though	IN
cord-001835-0s7ok4uw	1012	19	protein	protein	NN
cord-001835-0s7ok4uw	1012	20	-	-	HYPH
cord-001835-0s7ok4uw	1012	21	urea	urea	NN
cord-001835-0s7ok4uw	1012	22	interactions	interaction	NNS
cord-001835-0s7ok4uw	1012	23	are	be	VBP
cord-001835-0s7ok4uw	1012	24	considered	consider	VBN
cord-001835-0s7ok4uw	1012	25	to	to	TO
cord-001835-0s7ok4uw	1012	26	be	be	VB
cord-001835-0s7ok4uw	1012	27	crucial	crucial	JJ
cord-001835-0s7ok4uw	1012	28	.	.	.
cord-001835-0s7ok4uw	1013	1	Here	here	RB
cord-001835-0s7ok4uw	1013	2	,	,	,
cord-001835-0s7ok4uw	1013	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1013	4	provide	provide	VBP
cord-001835-0s7ok4uw	1013	5	NMR	NMR	NNP
cord-001835-0s7ok4uw	1013	6	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1013	7	and	and	CC
cord-001835-0s7ok4uw	1013	8	3D	3d	JJ
cord-001835-0s7ok4uw	1013	9	reconstructions	reconstruction	NNS
cord-001835-0s7ok4uw	1013	10	from	from	IN
cord-001835-0s7ok4uw	1013	11	X	x	NN
cord-001835-0s7ok4uw	1013	12	-	-	NN
cord-001835-0s7ok4uw	1013	13	ray	ray	NN
cord-001835-0s7ok4uw	1013	14	scattering	scattering	NN
cord-001835-0s7ok4uw	1013	15	to	to	TO
cord-001835-0s7ok4uw	1013	16	develop	develop	VB
cord-001835-0s7ok4uw	1013	17	the	the	DT
cord-001835-0s7ok4uw	1013	18	"	"	``
cord-001835-0s7ok4uw	1013	19	push	push	VB
cord-001835-0s7ok4uw	1013	20	-	-	HYPH
cord-001835-0s7ok4uw	1013	21	and	and	CC
cord-001835-0s7ok4uw	1013	22	-	-	HYPH
cord-001835-0s7ok4uw	1013	23	pull	pull	VB
cord-001835-0s7ok4uw	1013	24	"	"	''
cord-001835-0s7ok4uw	1013	25	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	1013	26	,	,	,
cord-001835-0s7ok4uw	1013	27	which	which	WDT
cord-001835-0s7ok4uw	1013	28	helps	help	VBZ
cord-001835-0s7ok4uw	1013	29	to	to	TO
cord-001835-0s7ok4uw	1013	30	explain	explain	VB
cord-001835-0s7ok4uw	1013	31	the	the	DT
cord-001835-0s7ok4uw	1013	32	initial	initial	JJ
cord-001835-0s7ok4uw	1013	33	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1013	34	of	of	IN
cord-001835-0s7ok4uw	1013	35	chemical	chemical	NN
cord-001835-0s7ok4uw	1013	36	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1013	37	in	in	IN
cord-001835-0s7ok4uw	1013	38	light	light	NN
cord-001835-0s7ok4uw	1013	39	of	of	IN
cord-001835-0s7ok4uw	1013	40	the	the	DT
cord-001835-0s7ok4uw	1013	41	physical	physical	JJ
cord-001835-0s7ok4uw	1013	42	events	event	NNS
cord-001835-0s7ok4uw	1013	43	triggered	trigger	VBN
cord-001835-0s7ok4uw	1013	44	by	by	IN
cord-001835-0s7ok4uw	1013	45	HP	HP	NNP
cord-001835-0s7ok4uw	1013	46	.	.	.
cord-001835-0s7ok4uw	1014	1	In	in	IN
cord-001835-0s7ok4uw	1014	2	studying	study	VBG
cord-001835-0s7ok4uw	1014	3	MpNep2	mpnep2	NN
cord-001835-0s7ok4uw	1014	4	from	from	IN
cord-001835-0s7ok4uw	1014	5	Moniliophthora	Moniliophthora	NNP
cord-001835-0s7ok4uw	1014	6	perniciosa	perniciosa	NNP
cord-001835-0s7ok4uw	1014	7	,	,	,
cord-001835-0s7ok4uw	1014	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	1014	9	tracked	track	VBD
cord-001835-0s7ok4uw	1014	10	two	two	CD
cord-001835-0s7ok4uw	1014	11	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	1014	12	units	unit	NNS
cord-001835-0s7ok4uw	1014	13	using	use	VBG
cord-001835-0s7ok4uw	1014	14	HP	HP	NNP
cord-001835-0s7ok4uw	1014	15	-	-	HYPH
cord-001835-0s7ok4uw	1014	16	NMR	NMR	NNP
cord-001835-0s7ok4uw	1014	17	as	as	IN
cord-001835-0s7ok4uw	1014	18	MpNep2	MpNep2	NNP
cord-001835-0s7ok4uw	1014	19	moved	move	VBD
cord-001835-0s7ok4uw	1014	20	uphill	uphill	RB
cord-001835-0s7ok4uw	1014	21	in	in	IN
cord-001835-0s7ok4uw	1014	22	the	the	DT
cord-001835-0s7ok4uw	1014	23	energy	energy	NN
cord-001835-0s7ok4uw	1014	24	landscape	landscape	NN
cord-001835-0s7ok4uw	1014	25	;	;	:
cord-001835-0s7ok4uw	1014	26	this	this	DT
cord-001835-0s7ok4uw	1014	27	process	process	NN
cord-001835-0s7ok4uw	1014	28	contrasts	contrast	VBZ
cord-001835-0s7ok4uw	1014	29	with	with	IN
cord-001835-0s7ok4uw	1014	30	the	the	DT
cord-001835-0s7ok4uw	1014	31	overall	overall	JJ
cord-001835-0s7ok4uw	1014	32	structural	structural	JJ
cord-001835-0s7ok4uw	1014	33	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1014	34	that	that	WDT
cord-001835-0s7ok4uw	1014	35	occurs	occur	VBZ
cord-001835-0s7ok4uw	1014	36	upon	upon	IN
cord-001835-0s7ok4uw	1014	37	reaching	reach	VBG
cord-001835-0s7ok4uw	1014	38	a	a	DT
cord-001835-0s7ok4uw	1014	39	threshold	threshold	NN
cord-001835-0s7ok4uw	1014	40	concentration	concentration	NN
cord-001835-0s7ok4uw	1014	41	of	of	IN
cord-001835-0s7ok4uw	1014	42	urea	urea	NN
cord-001835-0s7ok4uw	1014	43	.	.	.
cord-001835-0s7ok4uw	1015	1	At	at	IN
cord-001835-0s7ok4uw	1015	2	subdenaturing	subdenature	VBG
cord-001835-0s7ok4uw	1015	3	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1015	4	of	of	IN
cord-001835-0s7ok4uw	1015	5	urea	urea	NN
cord-001835-0s7ok4uw	1015	6	,	,	,
cord-001835-0s7ok4uw	1015	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	1015	8	were	be	VBD
cord-001835-0s7ok4uw	1015	9	able	able	JJ
cord-001835-0s7ok4uw	1015	10	to	to	TO
cord-001835-0s7ok4uw	1015	11	trap	trap	VB
cord-001835-0s7ok4uw	1015	12	a	a	DT
cord-001835-0s7ok4uw	1015	13	state	state	NN
cord-001835-0s7ok4uw	1015	14	in	in	IN
cord-001835-0s7ok4uw	1015	15	which	which	WDT
cord-001835-0s7ok4uw	1015	16	urea	urea	NN
cord-001835-0s7ok4uw	1015	17	is	be	VBZ
cord-001835-0s7ok4uw	1015	18	preferentially	preferentially	RB
cord-001835-0s7ok4uw	1015	19	bound	bind	VBN
cord-001835-0s7ok4uw	1015	20	to	to	IN
cord-001835-0s7ok4uw	1015	21	the	the	DT
cord-001835-0s7ok4uw	1015	22	protein	protein	NN
cord-001835-0s7ok4uw	1015	23	(	(	-LRB-
cord-001835-0s7ok4uw	1015	24	as	as	IN
cord-001835-0s7ok4uw	1015	25	determined	determine	VBN
cord-001835-0s7ok4uw	1015	26	by	by	IN
cord-001835-0s7ok4uw	1015	27	NMR	NMR	NNP
cord-001835-0s7ok4uw	1015	28	intensities	intensity	NNS
cord-001835-0s7ok4uw	1015	29	and	and	CC
cord-001835-0s7ok4uw	1015	30	chemical	chemical	NN
cord-001835-0s7ok4uw	1015	31	shifts	shift	NNS
cord-001835-0s7ok4uw	1015	32	)	)	-RRB-
cord-001835-0s7ok4uw	1015	33	;	;	:
cord-001835-0s7ok4uw	1015	34	this	this	DT
cord-001835-0s7ok4uw	1015	35	state	state	NN
cord-001835-0s7ok4uw	1015	36	is	be	VBZ
cord-001835-0s7ok4uw	1015	37	still	still	RB
cord-001835-0s7ok4uw	1015	38	folded	fold	VBN
cord-001835-0s7ok4uw	1015	39	and	and	CC
cord-001835-0s7ok4uw	1015	40	not	not	RB
cord-001835-0s7ok4uw	1015	41	additionally	additionally	RB
cord-001835-0s7ok4uw	1015	42	exposed	expose	VBN
cord-001835-0s7ok4uw	1015	43	to	to	IN
cord-001835-0s7ok4uw	1015	44	solvent	solvent	NN
cord-001835-0s7ok4uw	1015	45	[	[	-LRB-
cord-001835-0s7ok4uw	1015	46	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1015	47	and	and	CC
cord-001835-0s7ok4uw	1015	48	small	small	JJ
cord-001835-0s7ok4uw	1015	49	-	-	HYPH
cord-001835-0s7ok4uw	1015	50	angle	angle	NN
cord-001835-0s7ok4uw	1015	51	X	x	NN
cord-001835-0s7ok4uw	1015	52	-	-	NN
cord-001835-0s7ok4uw	1015	53	ray	ray	NN
cord-001835-0s7ok4uw	1015	54	scattering	scattering	NN
cord-001835-0s7ok4uw	1015	55	(	(	-LRB-
cord-001835-0s7ok4uw	1015	56	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	1015	57	)	)	-RRB-
cord-001835-0s7ok4uw	1015	58	]	]	-RRB-
cord-001835-0s7ok4uw	1015	59	.	.	.
cord-001835-0s7ok4uw	1016	1	This	this	DT
cord-001835-0s7ok4uw	1016	2	state	state	NN
cord-001835-0s7ok4uw	1016	3	has	have	VBZ
cord-001835-0s7ok4uw	1016	4	a	a	DT
cord-001835-0s7ok4uw	1016	5	higher	high	JJR
cord-001835-0s7ok4uw	1016	6	susceptibility	susceptibility	NN
cord-001835-0s7ok4uw	1016	7	to	to	TO
cord-001835-0s7ok4uw	1016	8	pressure	pressure	NN
cord-001835-0s7ok4uw	1016	9	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1016	10	(	(	-LRB-
cord-001835-0s7ok4uw	1016	11	lower	low	JJR
cord-001835-0s7ok4uw	1016	12	p1/2	p1/2	NN
cord-001835-0s7ok4uw	1016	13	and	and	CC
cord-001835-0s7ok4uw	1016	14	larger	large	JJR
cord-001835-0s7ok4uw	1016	15	DVu	DVu	NNS
cord-001835-0s7ok4uw	1016	16	)	)	-RRB-
cord-001835-0s7ok4uw	1016	17	;	;	:
cord-001835-0s7ok4uw	1016	18	thus	thus	RB
cord-001835-0s7ok4uw	1016	19	,	,	,
cord-001835-0s7ok4uw	1016	20	urea	urea	NN
cord-001835-0s7ok4uw	1016	21	and	and	CC
cord-001835-0s7ok4uw	1016	22	HP	HP	NNP
cord-001835-0s7ok4uw	1016	23	share	share	VBP
cord-001835-0s7ok4uw	1016	24	concomitant	concomitant	JJ
cord-001835-0s7ok4uw	1016	25	effects	effect	NNS
cord-001835-0s7ok4uw	1016	26	of	of	IN
cord-001835-0s7ok4uw	1016	27	urea	urea	NN
cord-001835-0s7ok4uw	1016	28	binding	binding	NN
cord-001835-0s7ok4uw	1016	29	and	and	CC
cord-001835-0s7ok4uw	1016	30	pulling	pulling	NN
cord-001835-0s7ok4uw	1016	31	and	and	CC
cord-001835-0s7ok4uw	1016	32	water	water	NN
cord-001835-0s7ok4uw	1016	33	-	-	HYPH
cord-001835-0s7ok4uw	1016	34	inducing	induce	VBG
cord-001835-0s7ok4uw	1016	35	pushing	push	VBG
cord-001835-0s7ok4uw	1016	36	,	,	,
cord-001835-0s7ok4uw	1016	37	respectively	respectively	RB
cord-001835-0s7ok4uw	1016	38	.	.	.
cord-001835-0s7ok4uw	1017	1	These	these	DT
cord-001835-0s7ok4uw	1017	2	observations	observation	NNS
cord-001835-0s7ok4uw	1017	3	explain	explain	VBP
cord-001835-0s7ok4uw	1017	4	the	the	DT
cord-001835-0s7ok4uw	1017	5	differences	difference	NNS
cord-001835-0s7ok4uw	1017	6	between	between	IN
cord-001835-0s7ok4uw	1017	7	the	the	DT
cord-001835-0s7ok4uw	1017	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	1017	9	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1017	10	that	that	WDT
cord-001835-0s7ok4uw	1017	11	control	control	VBP
cord-001835-0s7ok4uw	1017	12	the	the	DT
cord-001835-0s7ok4uw	1017	13	physical	physical	JJ
cord-001835-0s7ok4uw	1017	14	and	and	CC
cord-001835-0s7ok4uw	1017	15	chemical	chemical	JJ
cord-001835-0s7ok4uw	1017	16	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1017	17	of	of	IN
cord-001835-0s7ok4uw	1017	18	proteins	protein	NNS
cord-001835-0s7ok4uw	1017	19	,	,	,
cord-001835-0s7ok4uw	1017	20	thus	thus	RB
cord-001835-0s7ok4uw	1017	21	opening	open	VBG
cord-001835-0s7ok4uw	1017	22	up	up	RP
cord-001835-0s7ok4uw	1017	23	new	new	JJ
cord-001835-0s7ok4uw	1017	24	possibilities	possibility	NNS
cord-001835-0s7ok4uw	1017	25	for	for	IN
cord-001835-0s7ok4uw	1017	26	the	the	DT
cord-001835-0s7ok4uw	1017	27	study	study	NN
cord-001835-0s7ok4uw	1017	28	of	of	IN
cord-001835-0s7ok4uw	1017	29	protein	protein	NN
cord-001835-0s7ok4uw	1017	30	folding	folding	NN
cord-001835-0s7ok4uw	1017	31	and	and	CC
cord-001835-0s7ok4uw	1017	32	providing	provide	VBG
cord-001835-0s7ok4uw	1017	33	an	an	DT
cord-001835-0s7ok4uw	1017	34	interpretation	interpretation	NN
cord-001835-0s7ok4uw	1017	35	of	of	IN
cord-001835-0s7ok4uw	1017	36	the	the	DT
cord-001835-0s7ok4uw	1017	37	nature	nature	NN
cord-001835-0s7ok4uw	1017	38	of	of	IN
cord-001835-0s7ok4uw	1017	39	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	1017	40	in	in	IN
cord-001835-0s7ok4uw	1017	41	the	the	DT
cord-001835-0s7ok4uw	1017	42	folding	folding	NN
cord-001835-0s7ok4uw	1017	43	and	and	CC
cord-001835-0s7ok4uw	1017	44	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1017	45	processes	process	NNS
cord-001835-0s7ok4uw	1017	46	.	.	.
cord-001835-0s7ok4uw	1018	1	Zinc	zinc	NN
cord-001835-0s7ok4uw	1018	2	:	:	:
cord-001835-0s7ok4uw	1019	1	A	a	DT
cord-001835-0s7ok4uw	1019	2	Promoter	Promoter	NNP
cord-001835-0s7ok4uw	1019	3	or	or	CC
cord-001835-0s7ok4uw	1019	4	Inhibitor	Inhibitor	NNP
cord-001835-0s7ok4uw	1019	5	for	for	IN
cord-001835-0s7ok4uw	1019	6	IAPP	IAPP	NNP
cord-001835-0s7ok4uw	1019	7	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1019	8	?	?	.
cord-001835-0s7ok4uw	1020	1	Feng	Feng	NNP
cord-001835-0s7ok4uw	1020	2	Ding	Ding	NNP
cord-001835-0s7ok4uw	1020	3	1	1	CD
cord-001835-0s7ok4uw	1020	4	,	,	,
cord-001835-0s7ok4uw	1020	5	Praveen	Praveen	NNP
cord-001835-0s7ok4uw	1020	6	Nedumpully	Nedumpully	NNP
cord-001835-0s7ok4uw	1020	7	-	-	HYPH
cord-001835-0s7ok4uw	1020	8	Govindan	Govindan	NNP
cord-001835-0s7ok4uw	1020	9	1	1	CD
cord-001835-0s7ok4uw	1020	10	1	1	CD
cord-001835-0s7ok4uw	1020	11	Zinc	zinc	NN
cord-001835-0s7ok4uw	1020	12	ions	ion	NNS
cord-001835-0s7ok4uw	1020	13	have	have	VBP
cord-001835-0s7ok4uw	1020	14	been	be	VBN
cord-001835-0s7ok4uw	1020	15	found	find	VBN
cord-001835-0s7ok4uw	1020	16	to	to	TO
cord-001835-0s7ok4uw	1020	17	play	play	VB
cord-001835-0s7ok4uw	1020	18	an	an	DT
cord-001835-0s7ok4uw	1020	19	important	important	JJ
cord-001835-0s7ok4uw	1020	20	and	and	CC
cord-001835-0s7ok4uw	1020	21	yet	yet	RB
cord-001835-0s7ok4uw	1020	22	complex	complex	JJ
cord-001835-0s7ok4uw	1020	23	role	role	NN
cord-001835-0s7ok4uw	1020	24	in	in	IN
cord-001835-0s7ok4uw	1020	25	human	human	JJ
cord-001835-0s7ok4uw	1020	26	islet	islet	NN
cord-001835-0s7ok4uw	1020	27	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1020	28	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	1020	29	(	(	-LRB-
cord-001835-0s7ok4uw	1020	30	hIAPP	hIAPP	NNP
cord-001835-0s7ok4uw	1020	31	)	)	-RRB-
cord-001835-0s7ok4uw	1020	32	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1020	33	,	,	,
cord-001835-0s7ok4uw	1020	34	which	which	WDT
cord-001835-0s7ok4uw	1020	35	is	be	VBZ
cord-001835-0s7ok4uw	1020	36	associated	associate	VBN
cord-001835-0s7ok4uw	1020	37	with	with	IN
cord-001835-0s7ok4uw	1020	38	b	b	NN
cord-001835-0s7ok4uw	1020	39	-	-	HYPH
cord-001835-0s7ok4uw	1020	40	cell	cell	NN
cord-001835-0s7ok4uw	1020	41	death	death	NN
cord-001835-0s7ok4uw	1020	42	in	in	IN
cord-001835-0s7ok4uw	1020	43	type	type	NN
cord-001835-0s7ok4uw	1020	44	-	-	HYPH
cord-001835-0s7ok4uw	1020	45	II	II	NNP
cord-001835-0s7ok4uw	1020	46	diabetes	diabetes	NN
cord-001835-0s7ok4uw	1020	47	(	(	-LRB-
cord-001835-0s7ok4uw	1020	48	T2D	t2d	CD
cord-001835-0s7ok4uw	1020	49	)	)	-RRB-
cord-001835-0s7ok4uw	1020	50	.	.	.
cord-001835-0s7ok4uw	1021	1	Both	both	DT
cord-001835-0s7ok4uw	1021	2	concentration	concentration	NN
cord-001835-0s7ok4uw	1021	3	-	-	HYPH
cord-001835-0s7ok4uw	1021	4	dependent	dependent	JJ
cord-001835-0s7ok4uw	1021	5	promotion	promotion	NN
cord-001835-0s7ok4uw	1021	6	and	and	CC
cord-001835-0s7ok4uw	1021	7	inhibition	inhibition	NN
cord-001835-0s7ok4uw	1021	8	of	of	IN
cord-001835-0s7ok4uw	1021	9	IAPP	IAPP	NNP
cord-001835-0s7ok4uw	1021	10	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1021	11	by	by	IN
cord-001835-0s7ok4uw	1021	12	zinc	zinc	NN
cord-001835-0s7ok4uw	1021	13	ions	ion	NNS
cord-001835-0s7ok4uw	1021	14	have	have	VBP
cord-001835-0s7ok4uw	1021	15	been	be	VBN
cord-001835-0s7ok4uw	1021	16	observed	observe	VBN
cord-001835-0s7ok4uw	1021	17	in	in	IN
cord-001835-0s7ok4uw	1021	18	vitro	vitro	FW
cord-001835-0s7ok4uw	1021	19	.	.	.
cord-001835-0s7ok4uw	1022	1	Similarly	similarly	RB
cord-001835-0s7ok4uw	1022	2	,	,	,
cord-001835-0s7ok4uw	1022	3	at	at	IN
cord-001835-0s7ok4uw	1022	4	the	the	DT
cord-001835-0s7ok4uw	1022	5	population	population	NN
cord-001835-0s7ok4uw	1022	6	level	level	NN
cord-001835-0s7ok4uw	1022	7	,	,	,
cord-001835-0s7ok4uw	1022	8	both	both	DT
cord-001835-0s7ok4uw	1022	9	positive	positive	JJ
cord-001835-0s7ok4uw	1022	10	and	and	CC
cord-001835-0s7ok4uw	1022	11	negative	negative	JJ
cord-001835-0s7ok4uw	1022	12	correlations	correlation	NNS
cord-001835-0s7ok4uw	1022	13	were	be	VBD
cord-001835-0s7ok4uw	1022	14	reported	report	VBN
cord-001835-0s7ok4uw	1022	15	between	between	IN
cord-001835-0s7ok4uw	1022	16	the	the	DT
cord-001835-0s7ok4uw	1022	17	activity	activity	NN
cord-001835-0s7ok4uw	1022	18	of	of	IN
cord-001835-0s7ok4uw	1022	19	a	a	DT
cord-001835-0s7ok4uw	1022	20	b	b	NN
cord-001835-0s7ok4uw	1022	21	-	-	HYPH
cord-001835-0s7ok4uw	1022	22	cell	cell	NN
cord-001835-0s7ok4uw	1022	23	specific	specific	JJ
cord-001835-0s7ok4uw	1022	24	zinc	zinc	NN
cord-001835-0s7ok4uw	1022	25	transporter	transporter	NN
cord-001835-0s7ok4uw	1022	26	and	and	CC
cord-001835-0s7ok4uw	1022	27	T2D	t2d	CD
cord-001835-0s7ok4uw	1022	28	risk	risk	NN
cord-001835-0s7ok4uw	1022	29	.	.	.
cord-001835-0s7ok4uw	1023	1	Zinc	zinc	NN
cord-001835-0s7ok4uw	1023	2	ions	ion	NNS
cord-001835-0s7ok4uw	1023	3	are	be	VBP
cord-001835-0s7ok4uw	1023	4	able	able	JJ
cord-001835-0s7ok4uw	1023	5	to	to	TO
cord-001835-0s7ok4uw	1023	6	bind	bind	VB
cord-001835-0s7ok4uw	1023	7	a	a	DT
cord-001835-0s7ok4uw	1023	8	single	single	JJ
cord-001835-0s7ok4uw	1023	9	histidine	histidine	NN
cord-001835-0s7ok4uw	1023	10	in	in	IN
cord-001835-0s7ok4uw	1023	11	hIAPP	hIAPP	NNP
cord-001835-0s7ok4uw	1023	12	and	and	CC
cord-001835-0s7ok4uw	1023	13	coordinate	coordinate	VB
cord-001835-0s7ok4uw	1023	14	the	the	DT
cord-001835-0s7ok4uw	1023	15	formation	formation	NN
cord-001835-0s7ok4uw	1023	16	of	of	IN
cord-001835-0s7ok4uw	1023	17	zinc	zinc	NN
cord-001835-0s7ok4uw	1023	18	-	-	HYPH
cord-001835-0s7ok4uw	1023	19	bound	bind	VBN
cord-001835-0s7ok4uw	1023	20	hIAPP	hiapp	JJ
cord-001835-0s7ok4uw	1023	21	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	1023	22	.	.	.
cord-001835-0s7ok4uw	1024	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1024	2	hypothesize	hypothesize	VBP
cord-001835-0s7ok4uw	1024	3	that	that	IN
cord-001835-0s7ok4uw	1024	4	the	the	DT
cord-001835-0s7ok4uw	1024	5	relative	relative	JJ
cord-001835-0s7ok4uw	1024	6	zinc	zinc	NN
cord-001835-0s7ok4uw	1024	7	/	/	SYM
cord-001835-0s7ok4uw	1024	8	hIAPP	hiapp	JJ
cord-001835-0s7ok4uw	1024	9	concentration	concentration	NN
cord-001835-0s7ok4uw	1024	10	determines	determine	VBZ
cord-001835-0s7ok4uw	1024	11	the	the	DT
cord-001835-0s7ok4uw	1024	12	population	population	NN
cord-001835-0s7ok4uw	1024	13	of	of	IN
cord-001835-0s7ok4uw	1024	14	zinc	zinc	NN
cord-001835-0s7ok4uw	1024	15	-	-	HYPH
cord-001835-0s7ok4uw	1024	16	bound	bind	VBN
cord-001835-0s7ok4uw	1024	17	hIAPP	hiapp	JJ
cord-001835-0s7ok4uw	1024	18	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	1024	19	with	with	IN
cord-001835-0s7ok4uw	1024	20	different	different	JJ
cord-001835-0s7ok4uw	1024	21	molecular	molecular	JJ
cord-001835-0s7ok4uw	1024	22	weights	weight	NNS
cord-001835-0s7ok4uw	1024	23	.	.	.
cord-001835-0s7ok4uw	1025	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1025	2	have	have	VBP
cord-001835-0s7ok4uw	1025	3	applied	apply	VBN
cord-001835-0s7ok4uw	1025	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	1025	5	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1025	6	(	(	-LRB-
cord-001835-0s7ok4uw	1025	7	MD	MD	NNP
cord-001835-0s7ok4uw	1025	8	)	)	-RRB-
cord-001835-0s7ok4uw	1025	9	simulations	simulation	NNS
cord-001835-0s7ok4uw	1025	10	to	to	TO
cord-001835-0s7ok4uw	1025	11	systematically	systematically	RB
cord-001835-0s7ok4uw	1025	12	study	study	VB
cord-001835-0s7ok4uw	1025	13	the	the	DT
cord-001835-0s7ok4uw	1025	14	structure	structure	NN
cord-001835-0s7ok4uw	1025	15	and	and	CC
cord-001835-0s7ok4uw	1025	16	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1025	17	of	of	IN
cord-001835-0s7ok4uw	1025	18	a	a	DT
cord-001835-0s7ok4uw	1025	19	range	range	NN
cord-001835-0s7ok4uw	1025	20	of	of	IN
cord-001835-0s7ok4uw	1025	21	zinc	zinc	NN
cord-001835-0s7ok4uw	1025	22	-	-	HYPH
cord-001835-0s7ok4uw	1025	23	coordinated	coordinate	VBN
cord-001835-0s7ok4uw	1025	24	hIAPP	hiapp	JJ
cord-001835-0s7ok4uw	1025	25	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	1025	26	,	,	,
cord-001835-0s7ok4uw	1025	27	including	include	VBG
cord-001835-0s7ok4uw	1025	28	monomers	monomer	NNS
cord-001835-0s7ok4uw	1025	29	,	,	,
cord-001835-0s7ok4uw	1025	30	dimers	dimer	NNS
cord-001835-0s7ok4uw	1025	31	,	,	,
cord-001835-0s7ok4uw	1025	32	trimers	trimer	NNS
cord-001835-0s7ok4uw	1025	33	,	,	,
cord-001835-0s7ok4uw	1025	34	tetramers	tetramer	NNS
cord-001835-0s7ok4uw	1025	35	,	,	,
cord-001835-0s7ok4uw	1025	36	and	and	CC
cord-001835-0s7ok4uw	1025	37	hexamers	hexamer	NNS
cord-001835-0s7ok4uw	1025	38	.	.	.
cord-001835-0s7ok4uw	1026	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1026	2	computational	computational	JJ
cord-001835-0s7ok4uw	1026	3	results	result	NNS
cord-001835-0s7ok4uw	1026	4	suggest	suggest	VBP
cord-001835-0s7ok4uw	1026	5	that	that	IN
cord-001835-0s7ok4uw	1026	6	different	different	JJ
cord-001835-0s7ok4uw	1026	7	zinc	zinc	NN
cord-001835-0s7ok4uw	1026	8	-	-	HYPH
cord-001835-0s7ok4uw	1026	9	bound	bind	VBN
cord-001835-0s7ok4uw	1026	10	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	1026	11	have	have	VBP
cord-001835-0s7ok4uw	1026	12	distinct	distinct	JJ
cord-001835-0s7ok4uw	1026	13	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1026	14	propensities	propensity	NNS
cord-001835-0s7ok4uw	1026	15	.	.	.
cord-001835-0s7ok4uw	1027	1	High	high	JJ
cord-001835-0s7ok4uw	1027	2	-	-	HYPH
cord-001835-0s7ok4uw	1027	3	molecular	molecular	JJ
cord-001835-0s7ok4uw	1027	4	weight	weight	NN
cord-001835-0s7ok4uw	1027	5	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	1027	6	(	(	-LRB-
cord-001835-0s7ok4uw	1027	7	2	2	CD
cord-001835-0s7ok4uw	1027	8	peptides	peptide	NNS
cord-001835-0s7ok4uw	1027	9	)	)	-RRB-
cord-001835-0s7ok4uw	1027	10	have	have	VBP
cord-001835-0s7ok4uw	1027	11	higher	high	JJR
cord-001835-0s7ok4uw	1027	12	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1027	13	propensity	propensity	NN
cord-001835-0s7ok4uw	1027	14	than	than	IN
cord-001835-0s7ok4uw	1027	15	zinc	zinc	NN
cord-001835-0s7ok4uw	1027	16	-	-	HYPH
cord-001835-0s7ok4uw	1027	17	free	free	JJ
cord-001835-0s7ok4uw	1027	18	and	and	CC
cord-001835-0s7ok4uw	1027	19	zinc	zinc	NN
cord-001835-0s7ok4uw	1027	20	-	-	HYPH
cord-001835-0s7ok4uw	1027	21	bound	bind	VBN
cord-001835-0s7ok4uw	1027	22	hIAPP	hiapp	JJ
cord-001835-0s7ok4uw	1027	23	monomers	monomer	NNS
cord-001835-0s7ok4uw	1027	24	at	at	IN
cord-001835-0s7ok4uw	1027	25	2	2	CD
cord-001835-0s7ok4uw	1027	26	mM	mm	CD
cord-001835-0s7ok4uw	1027	27	concentration	concentration	NN
cord-001835-0s7ok4uw	1027	28	in	in	IN
cord-001835-0s7ok4uw	1027	29	silico	silico	NNS
cord-001835-0s7ok4uw	1027	30	.	.	.
cord-001835-0s7ok4uw	1028	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	1028	2	,	,	,
cord-001835-0s7ok4uw	1028	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1028	4	results	result	NNS
cord-001835-0s7ok4uw	1028	5	provide	provide	VBP
cord-001835-0s7ok4uw	1028	6	a	a	DT
cord-001835-0s7ok4uw	1028	7	molecular	molecular	JJ
cord-001835-0s7ok4uw	1028	8	insight	insight	NN
cord-001835-0s7ok4uw	1028	9	into	into	IN
cord-001835-0s7ok4uw	1028	10	the	the	DT
cord-001835-0s7ok4uw	1028	11	complex	complex	JJ
cord-001835-0s7ok4uw	1028	12	role	role	NN
cord-001835-0s7ok4uw	1028	13	of	of	IN
cord-001835-0s7ok4uw	1028	14	direct	direct	JJ
cord-001835-0s7ok4uw	1028	15	zinc	zinc	NN
cord-001835-0s7ok4uw	1028	16	binding	bind	VBG
cord-001835-0s7ok4uw	1028	17	on	on	IN
cord-001835-0s7ok4uw	1028	18	hIAPP	hiapp	JJ
cord-001835-0s7ok4uw	1028	19	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1028	20	.	.	.
cord-001835-0s7ok4uw	1029	1	At	at	IN
cord-001835-0s7ok4uw	1029	2	low	low	JJ
cord-001835-0s7ok4uw	1029	3	zinc	zinc	NN
cord-001835-0s7ok4uw	1029	4	/	/	SYM
cord-001835-0s7ok4uw	1029	5	hIAPP	hiapp	JJ
cord-001835-0s7ok4uw	1029	6	stoichiometry	stoichiometry	NN
cord-001835-0s7ok4uw	1029	7	,	,	,
cord-001835-0s7ok4uw	1029	8	zinc	zinc	NN
cord-001835-0s7ok4uw	1029	9	binding	binding	NN
cord-001835-0s7ok4uw	1029	10	promotes	promote	VBZ
cord-001835-0s7ok4uw	1029	11	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1029	12	.	.	.
cord-001835-0s7ok4uw	1030	1	As	as	IN
cord-001835-0s7ok4uw	1030	2	the	the	DT
cord-001835-0s7ok4uw	1030	3	stoichiometry	stoichiometry	NN
cord-001835-0s7ok4uw	1030	4	increases	increase	NNS
cord-001835-0s7ok4uw	1030	5	and	and	CC
cord-001835-0s7ok4uw	1030	6	zinc	zinc	NN
cord-001835-0s7ok4uw	1030	7	ions	ion	NNS
cord-001835-0s7ok4uw	1030	8	bind	bind	VBP
cord-001835-0s7ok4uw	1030	9	to	to	IN
cord-001835-0s7ok4uw	1030	10	single	single	JJ
cord-001835-0s7ok4uw	1030	11	hIAPP	hiapp	JJ
cord-001835-0s7ok4uw	1030	12	peptides	peptide	NNS
cord-001835-0s7ok4uw	1030	13	,	,	,
cord-001835-0s7ok4uw	1030	14	the	the	DT
cord-001835-0s7ok4uw	1030	15	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1030	16	of	of	IN
cord-001835-0s7ok4uw	1030	17	hIAPP	hIAPP	NNP
cord-001835-0s7ok4uw	1030	18	is	be	VBZ
cord-001835-0s7ok4uw	1030	19	inhibited	inhibit	VBN
cord-001835-0s7ok4uw	1030	20	due	due	IN
cord-001835-0s7ok4uw	1030	21	to	to	IN
cord-001835-0s7ok4uw	1030	22	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	1030	23	repulsion	repulsion	NN
cord-001835-0s7ok4uw	1030	24	between	between	IN
cord-001835-0s7ok4uw	1030	25	the	the	DT
cord-001835-0s7ok4uw	1030	26	charged	charge	VBN
cord-001835-0s7ok4uw	1030	27	zinc	zinc	NN
cord-001835-0s7ok4uw	1030	28	ions	ion	NNS
cord-001835-0s7ok4uw	1030	29	.	.	.
cord-001835-0s7ok4uw	1031	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1031	2	computational	computational	JJ
cord-001835-0s7ok4uw	1031	3	study	study	NN
cord-001835-0s7ok4uw	1031	4	sheds	shed	VBZ
cord-001835-0s7ok4uw	1031	5	light	light	NN
cord-001835-0s7ok4uw	1031	6	on	on	IN
cord-001835-0s7ok4uw	1031	7	the	the	DT
cord-001835-0s7ok4uw	1031	8	complex	complex	JJ
cord-001835-0s7ok4uw	1031	9	role	role	NN
cord-001835-0s7ok4uw	1031	10	of	of	IN
cord-001835-0s7ok4uw	1031	11	zinc	zinc	NN
cord-001835-0s7ok4uw	1031	12	on	on	IN
cord-001835-0s7ok4uw	1031	13	hIAPP	hiapp	JJ
cord-001835-0s7ok4uw	1031	14	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1031	15	and	and	CC
cord-001835-0s7ok4uw	1031	16	T2D	t2d	DT
cord-001835-0s7ok4uw	1031	17	development	development	NN
cord-001835-0s7ok4uw	1031	18	.	.	.
cord-001835-0s7ok4uw	1031	19	 	 	_SP
cord-001835-0s7ok4uw	1032	1	Biomolecules	Biomolecules	NNP
cord-001835-0s7ok4uw	1032	2	function	function	VBP
cord-001835-0s7ok4uw	1032	3	in	in	IN
cord-001835-0s7ok4uw	1032	4	the	the	DT
cord-001835-0s7ok4uw	1032	5	densely	densely	RB
cord-001835-0s7ok4uw	1032	6	crowded	crowded	JJ
cord-001835-0s7ok4uw	1032	7	and	and	CC
cord-001835-0s7ok4uw	1032	8	highly	highly	RB
cord-001835-0s7ok4uw	1032	9	heterogeneous	heterogeneous	JJ
cord-001835-0s7ok4uw	1032	10	cell	cell	NN
cord-001835-0s7ok4uw	1032	11	,	,	,
cord-001835-0s7ok4uw	1032	12	which	which	WDT
cord-001835-0s7ok4uw	1032	13	is	be	VBZ
cord-001835-0s7ok4uw	1032	14	filled	fill	VBN
cord-001835-0s7ok4uw	1032	15	up	up	RP
cord-001835-0s7ok4uw	1032	16	to	to	IN
cord-001835-0s7ok4uw	1032	17	a	a	DT
cord-001835-0s7ok4uw	1032	18	volume	volume	NN
cord-001835-0s7ok4uw	1032	19	of	of	IN
cord-001835-0s7ok4uw	1032	20	40	40	CD
cord-001835-0s7ok4uw	1032	21	%	%	NN
cord-001835-0s7ok4uw	1032	22	with	with	IN
cord-001835-0s7ok4uw	1032	23	macromolecules	macromolecule	NNS
cord-001835-0s7ok4uw	1032	24	[	[	-LRB-
cord-001835-0s7ok4uw	1032	25	1	1	CD
cord-001835-0s7ok4uw	1032	26	]	]	-RRB-
cord-001835-0s7ok4uw	1032	27	.	.	.
cord-001835-0s7ok4uw	1033	1	Often	often	RB
cord-001835-0s7ok4uw	1033	2	,	,	,
cord-001835-0s7ok4uw	1033	3	artificial	artificial	JJ
cord-001835-0s7ok4uw	1033	4	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	1033	5	crowding	crowd	VBG
cord-001835-0s7ok4uw	1033	6	agents	agent	NNS
cord-001835-0s7ok4uw	1033	7	are	be	VBP
cord-001835-0s7ok4uw	1033	8	used	use	VBN
cord-001835-0s7ok4uw	1033	9	to	to	TO
cord-001835-0s7ok4uw	1033	10	mimic	mimic	VB
cord-001835-0s7ok4uw	1033	11	these	these	DT
cord-001835-0s7ok4uw	1033	12	conditions	condition	NNS
cord-001835-0s7ok4uw	1033	13	in	in	IN
cord-001835-0s7ok4uw	1033	14	vitro	vitro	FW
cord-001835-0s7ok4uw	1033	15	and	and	CC
cord-001835-0s7ok4uw	1033	16	the	the	DT
cord-001835-0s7ok4uw	1033	17	excluded	exclude	VBN
cord-001835-0s7ok4uw	1033	18	volume	volume	NN
cord-001835-0s7ok4uw	1033	19	theory	theory	NN
cord-001835-0s7ok4uw	1033	20	is	be	VBZ
cord-001835-0s7ok4uw	1033	21	applied	apply	VBN
cord-001835-0s7ok4uw	1033	22	to	to	TO
cord-001835-0s7ok4uw	1033	23	explain	explain	VB
cord-001835-0s7ok4uw	1033	24	the	the	DT
cord-001835-0s7ok4uw	1033	25	observed	observed	JJ
cord-001835-0s7ok4uw	1033	26	effects	effect	NNS
cord-001835-0s7ok4uw	1033	27	[	[	-LRB-
cord-001835-0s7ok4uw	1033	28	2	2	CD
cord-001835-0s7ok4uw	1033	29	]	]	-RRB-
cord-001835-0s7ok4uw	1033	30	.	.	.
cord-001835-0s7ok4uw	1034	1	However	however	RB
cord-001835-0s7ok4uw	1034	2	,	,	,
cord-001835-0s7ok4uw	1034	3	recent	recent	JJ
cord-001835-0s7ok4uw	1034	4	studies	study	NNS
cord-001835-0s7ok4uw	1034	5	emphasize	emphasize	VBP
cord-001835-0s7ok4uw	1034	6	the	the	DT
cord-001835-0s7ok4uw	1034	7	role	role	NN
cord-001835-0s7ok4uw	1034	8	of	of	IN
cord-001835-0s7ok4uw	1034	9	further	further	JJ
cord-001835-0s7ok4uw	1034	10	contributions	contribution	NNS
cord-001835-0s7ok4uw	1034	11	aside	aside	RB
cord-001835-0s7ok4uw	1034	12	from	from	IN
cord-001835-0s7ok4uw	1034	13	a	a	DT
cord-001835-0s7ok4uw	1034	14	pure	pure	JJ
cord-001835-0s7ok4uw	1034	15	volume	volume	NN
cord-001835-0s7ok4uw	1034	16	effect	effect	NN
cord-001835-0s7ok4uw	1034	17	including	include	VBG
cord-001835-0s7ok4uw	1034	18	enthalpic	enthalpic	NN
cord-001835-0s7ok4uw	1034	19	and	and	CC
cord-001835-0s7ok4uw	1034	20	solvent	solvent	NN
cord-001835-0s7ok4uw	1034	21	effects	effect	NNS
cord-001835-0s7ok4uw	1034	22	[	[	-LRB-
cord-001835-0s7ok4uw	1034	23	3	3	CD
cord-001835-0s7ok4uw	1034	24	,	,	,
cord-001835-0s7ok4uw	1034	25	4	4	CD
cord-001835-0s7ok4uw	1034	26	]	]	-RRB-
cord-001835-0s7ok4uw	1034	27	.	.	.
cord-001835-0s7ok4uw	1035	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1035	2	study	study	VBP
cord-001835-0s7ok4uw	1035	3	cosolute	cosolute	JJ
cord-001835-0s7ok4uw	1035	4	effects	effect	NNS
cord-001835-0s7ok4uw	1035	5	at	at	IN
cord-001835-0s7ok4uw	1035	6	high	high	JJ
cord-001835-0s7ok4uw	1035	7	molecular	molecular	JJ
cord-001835-0s7ok4uw	1035	8	and	and	CC
cord-001835-0s7ok4uw	1035	9	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	1035	10	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1035	11	via	via	IN
cord-001835-0s7ok4uw	1035	12	a	a	DT
cord-001835-0s7ok4uw	1035	13	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1035	14	analysis	analysis	NN
cord-001835-0s7ok4uw	1035	15	of	of	IN
cord-001835-0s7ok4uw	1035	16	the	the	DT
cord-001835-0s7ok4uw	1035	17	thermal	thermal	JJ
cord-001835-0s7ok4uw	1035	18	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1035	19	of	of	IN
cord-001835-0s7ok4uw	1035	20	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	1035	21	in	in	IN
cord-001835-0s7ok4uw	1035	22	the	the	DT
cord-001835-0s7ok4uw	1035	23	presence	presence	NN
cord-001835-0s7ok4uw	1035	24	of	of	IN
cord-001835-0s7ok4uw	1035	25	different	different	JJ
cord-001835-0s7ok4uw	1035	26	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1035	27	of	of	IN
cord-001835-0s7ok4uw	1035	28	cosolutes	cosolute	NNS
cord-001835-0s7ok4uw	1035	29	(	(	-LRB-
cord-001835-0s7ok4uw	1035	30	glucose	glucose	NN
cord-001835-0s7ok4uw	1035	31	,	,	,
cord-001835-0s7ok4uw	1035	32	dextran	dextran	NN
cord-001835-0s7ok4uw	1035	33	,	,	,
cord-001835-0s7ok4uw	1035	34	polyethylene	polyethylene	NN
cord-001835-0s7ok4uw	1035	35	glycol	glycol	NN
cord-001835-0s7ok4uw	1035	36	,	,	,
cord-001835-0s7ok4uw	1035	37	potassium	potassium	NN
cord-001835-0s7ok4uw	1035	38	chloride	chloride	NN
cord-001835-0s7ok4uw	1035	39	)	)	-RRB-
cord-001835-0s7ok4uw	1035	40	[	[	-LRB-
cord-001835-0s7ok4uw	1035	41	5	5	CD
cord-001835-0s7ok4uw	1035	42	]	]	-RRB-
cord-001835-0s7ok4uw	1035	43	.	.	.
cord-001835-0s7ok4uw	1036	1	In	in	IN
cord-001835-0s7ok4uw	1036	2	contrast	contrast	NN
cord-001835-0s7ok4uw	1036	3	to	to	IN
cord-001835-0s7ok4uw	1036	4	the	the	DT
cord-001835-0s7ok4uw	1036	5	excluded	exclude	VBN
cord-001835-0s7ok4uw	1036	6	volume	volume	NN
cord-001835-0s7ok4uw	1036	7	theory	theory	NN
cord-001835-0s7ok4uw	1036	8	,	,	,
cord-001835-0s7ok4uw	1036	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	1036	10	observed	observe	VBD
cord-001835-0s7ok4uw	1036	11	enthalpic	enthalpic	JJ
cord-001835-0s7ok4uw	1036	12	stabilization	stabilization	NN
cord-001835-0s7ok4uw	1036	13	and	and	CC
cord-001835-0s7ok4uw	1036	14	entropic	entropic	JJ
cord-001835-0s7ok4uw	1036	15	destabilization	destabilization	NN
cord-001835-0s7ok4uw	1036	16	forces	force	NNS
cord-001835-0s7ok4uw	1036	17	for	for	IN
cord-001835-0s7ok4uw	1036	18	all	all	DT
cord-001835-0s7ok4uw	1036	19	tested	test	VBN
cord-001835-0s7ok4uw	1036	20	cosolutes	cosolute	NNS
cord-001835-0s7ok4uw	1036	21	.	.	.
cord-001835-0s7ok4uw	1037	1	The	the	DT
cord-001835-0s7ok4uw	1037	2	enthalpic	enthalpic	JJ
cord-001835-0s7ok4uw	1037	3	stabilization	stabilization	NN
cord-001835-0s7ok4uw	1037	4	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1037	5	of	of	IN
cord-001835-0s7ok4uw	1037	6	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	1037	7	in	in	IN
cord-001835-0s7ok4uw	1037	8	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	1037	9	polysaccharide	polysaccharide	NN
cord-001835-0s7ok4uw	1037	10	solutions	solution	NNS
cord-001835-0s7ok4uw	1037	11	of	of	IN
cord-001835-0s7ok4uw	1037	12	dextran	dextran	NN
cord-001835-0s7ok4uw	1037	13	was	be	VBD
cord-001835-0s7ok4uw	1037	14	thereby	thereby	RB
cord-001835-0s7ok4uw	1037	15	similar	similar	JJ
cord-001835-0s7ok4uw	1037	16	to	to	IN
cord-001835-0s7ok4uw	1037	17	the	the	DT
cord-001835-0s7ok4uw	1037	18	effects	effect	NNS
cord-001835-0s7ok4uw	1037	19	observed	observe	VBN
cord-001835-0s7ok4uw	1037	20	in	in	IN
cord-001835-0s7ok4uw	1037	21	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	1037	22	glucose	glucose	NN
cord-001835-0s7ok4uw	1037	23	.	.	.
cord-001835-0s7ok4uw	1038	1	Further	further	RB
cord-001835-0s7ok4uw	1038	2	,	,	,
cord-001835-0s7ok4uw	1038	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	1038	4	remains	remain	VBZ
cord-001835-0s7ok4uw	1038	5	unclear	unclear	JJ
cord-001835-0s7ok4uw	1038	6	how	how	WRB
cord-001835-0s7ok4uw	1038	7	such	such	JJ
cord-001835-0s7ok4uw	1038	8	cosolutes	cosolute	NNS
cord-001835-0s7ok4uw	1038	9	reflect	reflect	VBP
cord-001835-0s7ok4uw	1038	10	the	the	DT
cord-001835-0s7ok4uw	1038	11	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	1038	12	properties	property	NNS
cord-001835-0s7ok4uw	1038	13	of	of	IN
cord-001835-0s7ok4uw	1038	14	the	the	DT
cord-001835-0s7ok4uw	1038	15	complex	complex	JJ
cord-001835-0s7ok4uw	1038	16	cell	cell	NN
cord-001835-0s7ok4uw	1038	17	environment	environment	NN
cord-001835-0s7ok4uw	1038	18	as	as	IN
cord-001835-0s7ok4uw	1038	19	a	a	DT
cord-001835-0s7ok4uw	1038	20	characterization	characterization	NN
cord-001835-0s7ok4uw	1038	21	of	of	IN
cord-001835-0s7ok4uw	1038	22	the	the	DT
cord-001835-0s7ok4uw	1038	23	in	in	IN
cord-001835-0s7ok4uw	1038	24	-	-	HYPH
cord-001835-0s7ok4uw	1038	25	cell	cell	NN
cord-001835-0s7ok4uw	1038	26	crowding	crowding	NN
cord-001835-0s7ok4uw	1038	27	effect	effect	NN
cord-001835-0s7ok4uw	1038	28	is	be	VBZ
cord-001835-0s7ok4uw	1038	29	lacking	lack	VBG
cord-001835-0s7ok4uw	1038	30	.	.	.
cord-001835-0s7ok4uw	1039	1	Thus	thus	RB
cord-001835-0s7ok4uw	1039	2	,	,	,
cord-001835-0s7ok4uw	1039	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1039	4	developed	develop	VBD
cord-001835-0s7ok4uw	1039	5	a	a	DT
cord-001835-0s7ok4uw	1039	6	FRET	fret	NN
cord-001835-0s7ok4uw	1039	7	-	-	HYPH
cord-001835-0s7ok4uw	1039	8	based	base	VBN
cord-001835-0s7ok4uw	1039	9	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	1039	10	crowding	crowding	NN
cord-001835-0s7ok4uw	1039	11	sensor	sensor	NN
cord-001835-0s7ok4uw	1039	12	to	to	TO
cord-001835-0s7ok4uw	1039	13	study	study	VB
cord-001835-0s7ok4uw	1039	14	the	the	DT
cord-001835-0s7ok4uw	1039	15	crowding	crowding	NN
cord-001835-0s7ok4uw	1039	16	effect	effect	NN
cord-001835-0s7ok4uw	1039	17	in	in	IN
cord-001835-0s7ok4uw	1039	18	living	living	NN
cord-001835-0s7ok4uw	1039	19	cells	cell	NNS
cord-001835-0s7ok4uw	1039	20	[	[	-LRB-
cord-001835-0s7ok4uw	1039	21	6	6	CD
cord-001835-0s7ok4uw	1039	22	]	]	-RRB-
cord-001835-0s7ok4uw	1039	23	.	.	.
cord-001835-0s7ok4uw	1040	1	The	the	DT
cord-001835-0s7ok4uw	1040	2	averaged	average	VBN
cord-001835-0s7ok4uw	1040	3	conformation	conformation	NN
cord-001835-0s7ok4uw	1040	4	of	of	IN
cord-001835-0s7ok4uw	1040	5	the	the	DT
cord-001835-0s7ok4uw	1040	6	sensor	sensor	NN
cord-001835-0s7ok4uw	1040	7	is	be	VBZ
cord-001835-0s7ok4uw	1040	8	similar	similar	JJ
cord-001835-0s7ok4uw	1040	9	to	to	TO
cord-001835-0s7ok4uw	1040	10	dilute	dilute	VB
cord-001835-0s7ok4uw	1040	11	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	1040	12	buffer	buffer	NN
cord-001835-0s7ok4uw	1040	13	and	and	CC
cord-001835-0s7ok4uw	1040	14	cell	cell	NN
cord-001835-0s7ok4uw	1040	15	lysate	lysate	NN
cord-001835-0s7ok4uw	1040	16	.	.	.
cord-001835-0s7ok4uw	1041	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1041	2	find	find	VBP
cord-001835-0s7ok4uw	1041	3	that	that	IN
cord-001835-0s7ok4uw	1041	4	the	the	DT
cord-001835-0s7ok4uw	1041	5	in	in	IN
cord-001835-0s7ok4uw	1041	6	-	-	HYPH
cord-001835-0s7ok4uw	1041	7	cell	cell	NN
cord-001835-0s7ok4uw	1041	8	crowding	crowding	NN
cord-001835-0s7ok4uw	1041	9	effect	effect	NN
cord-001835-0s7ok4uw	1041	10	is	be	VBZ
cord-001835-0s7ok4uw	1041	11	distributed	distribute	VBN
cord-001835-0s7ok4uw	1041	12	heterogeneously	heterogeneously	RB
cord-001835-0s7ok4uw	1041	13	and	and	CC
cord-001835-0s7ok4uw	1041	14	can	can	MD
cord-001835-0s7ok4uw	1041	15	change	change	VB
cord-001835-0s7ok4uw	1041	16	significantly	significantly	RB
cord-001835-0s7ok4uw	1041	17	upon	upon	IN
cord-001835-0s7ok4uw	1041	18	osmotic	osmotic	JJ
cord-001835-0s7ok4uw	1041	19	stress	stress	NN
cord-001835-0s7ok4uw	1041	20	.	.	.
cord-001835-0s7ok4uw	1042	1	The	the	DT
cord-001835-0s7ok4uw	1042	2	presented	present	VBN
cord-001835-0s7ok4uw	1042	3	method	method	NN
cord-001835-0s7ok4uw	1042	4	allows	allow	VBZ
cord-001835-0s7ok4uw	1042	5	to	to	TO
cord-001835-0s7ok4uw	1042	6	systematically	systematically	RB
cord-001835-0s7ok4uw	1042	7	study	study	VB
cord-001835-0s7ok4uw	1042	8	in	in	IN
cord-001835-0s7ok4uw	1042	9	-	-	HYPH
cord-001835-0s7ok4uw	1042	10	cell	cell	NN
cord-001835-0s7ok4uw	1042	11	crowding	crowding	NN
cord-001835-0s7ok4uw	1042	12	effects	effect	NNS
cord-001835-0s7ok4uw	1042	13	and	and	CC
cord-001835-0s7ok4uw	1042	14	understand	understand	VB
cord-001835-0s7ok4uw	1042	15	them	-PRON-	PRP
cord-001835-0s7ok4uw	1042	16	as	as	IN
cord-001835-0s7ok4uw	1042	17	a	a	DT
cord-001835-0s7ok4uw	1042	18	modulator	modulator	NN
cord-001835-0s7ok4uw	1042	19	of	of	IN
cord-001835-0s7ok4uw	1042	20	biomolecular	biomolecular	JJ
cord-001835-0s7ok4uw	1042	21	function	function	NN
cord-001835-0s7ok4uw	1042	22	.	.	.
cord-001835-0s7ok4uw	1043	1	The	the	DT
cord-001835-0s7ok4uw	1043	2	stability	stability	NN
cord-001835-0s7ok4uw	1043	3	of	of	IN
cord-001835-0s7ok4uw	1043	4	biomolecules	biomolecule	NNS
cord-001835-0s7ok4uw	1043	5	under	under	IN
cord-001835-0s7ok4uw	1043	6	co	co	JJ
cord-001835-0s7ok4uw	1043	7	-	-	JJ
cord-001835-0s7ok4uw	1043	8	solvent	solvent	JJ
cord-001835-0s7ok4uw	1043	9	conditions	condition	NNS
cord-001835-0s7ok4uw	1043	10	is	be	VBZ
cord-001835-0s7ok4uw	1043	11	dependent	dependent	JJ
cord-001835-0s7ok4uw	1043	12	on	on	IN
cord-001835-0s7ok4uw	1043	13	the	the	DT
cord-001835-0s7ok4uw	1043	14	nature	nature	NN
cord-001835-0s7ok4uw	1043	15	of	of	IN
cord-001835-0s7ok4uw	1043	16	the	the	DT
cord-001835-0s7ok4uw	1043	17	co	co	NN
cord-001835-0s7ok4uw	1043	18	-	-	NN
cord-001835-0s7ok4uw	1043	19	solvent	solvent	JJ
cord-001835-0s7ok4uw	1043	20	[	[	-LRB-
cord-001835-0s7ok4uw	1043	21	1	1	CD
cord-001835-0s7ok4uw	1043	22	]	]	-RRB-
cord-001835-0s7ok4uw	1043	23	.	.	.
cord-001835-0s7ok4uw	1044	1	This	this	DT
cord-001835-0s7ok4uw	1044	2	can	can	MD
cord-001835-0s7ok4uw	1044	3	alter	alter	VB
cord-001835-0s7ok4uw	1044	4	a	a	DT
cord-001835-0s7ok4uw	1044	5	protein	protein	NN
cord-001835-0s7ok4uw	1044	6	's	's	POS
cord-001835-0s7ok4uw	1044	7	properties	property	NNS
cord-001835-0s7ok4uw	1044	8	and	and	CC
cord-001835-0s7ok4uw	1044	9	structural	structural	JJ
cord-001835-0s7ok4uw	1044	10	features	feature	NNS
cord-001835-0s7ok4uw	1044	11	through	through	IN
cord-001835-0s7ok4uw	1044	12	biomolecular	biomolecular	JJ
cord-001835-0s7ok4uw	1044	13	interactions	interaction	NNS
cord-001835-0s7ok4uw	1044	14	between	between	IN
cord-001835-0s7ok4uw	1044	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1044	16	functional	functional	JJ
cord-001835-0s7ok4uw	1044	17	groups	group	NNS
cord-001835-0s7ok4uw	1044	18	and	and	CC
cord-001835-0s7ok4uw	1044	19	the	the	DT
cord-001835-0s7ok4uw	1044	20	co	co	NN
cord-001835-0s7ok4uw	1044	21	-	-	NN
cord-001835-0s7ok4uw	1044	22	solvent	solvent	JJ
cord-001835-0s7ok4uw	1044	23	molecules	molecule	NNS
cord-001835-0s7ok4uw	1044	24	.	.	.
cord-001835-0s7ok4uw	1045	1	Ionic	ionic	JJ
cord-001835-0s7ok4uw	1045	2	liquids	liquid	NNS
cord-001835-0s7ok4uw	1045	3	(	(	-LRB-
cord-001835-0s7ok4uw	1045	4	ILs	il	NNS
cord-001835-0s7ok4uw	1045	5	)	)	-RRB-
cord-001835-0s7ok4uw	1045	6	represent	represent	VBP
cord-001835-0s7ok4uw	1045	7	a	a	DT
cord-001835-0s7ok4uw	1045	8	rather	rather	RB
cord-001835-0s7ok4uw	1045	9	diverse	diverse	JJ
cord-001835-0s7ok4uw	1045	10	class	class	NN
cord-001835-0s7ok4uw	1045	11	of	of	IN
cord-001835-0s7ok4uw	1045	12	co	co	NNS
cord-001835-0s7ok4uw	1045	13	-	-	NNS
cord-001835-0s7ok4uw	1045	14	solvents	solvent	NNS
cord-001835-0s7ok4uw	1045	15	.	.	.
cord-001835-0s7ok4uw	1046	1	The	the	DT
cord-001835-0s7ok4uw	1046	2	design	design	NN
cord-001835-0s7ok4uw	1046	3	flexibility	flexibility	NN
cord-001835-0s7ok4uw	1046	4	of	of	IN
cord-001835-0s7ok4uw	1046	5	these	these	DT
cord-001835-0s7ok4uw	1046	6	molten	molten	JJ
cord-001835-0s7ok4uw	1046	7	salts	salt	NNS
cord-001835-0s7ok4uw	1046	8	is	be	VBZ
cord-001835-0s7ok4uw	1046	9	an	an	DT
cord-001835-0s7ok4uw	1046	10	attractive	attractive	JJ
cord-001835-0s7ok4uw	1046	11	feature	feature	NN
cord-001835-0s7ok4uw	1046	12	,	,	,
cord-001835-0s7ok4uw	1046	13	allowing	allow	VBG
cord-001835-0s7ok4uw	1046	14	the	the	DT
cord-001835-0s7ok4uw	1046	15	properties	property	NNS
cord-001835-0s7ok4uw	1046	16	of	of	IN
cord-001835-0s7ok4uw	1046	17	the	the	DT
cord-001835-0s7ok4uw	1046	18	IL	IL	NNP
cord-001835-0s7ok4uw	1046	19	to	to	TO
cord-001835-0s7ok4uw	1046	20	be	be	VB
cord-001835-0s7ok4uw	1046	21	tuned	tune	VBN
cord-001835-0s7ok4uw	1046	22	to	to	TO
cord-001835-0s7ok4uw	1046	23	meet	meet	VB
cord-001835-0s7ok4uw	1046	24	the	the	DT
cord-001835-0s7ok4uw	1046	25	requirements	requirement	NNS
cord-001835-0s7ok4uw	1046	26	of	of	IN
cord-001835-0s7ok4uw	1046	27	different	different	JJ
cord-001835-0s7ok4uw	1046	28	applications	application	NNS
cord-001835-0s7ok4uw	1046	29	[	[	-LRB-
cord-001835-0s7ok4uw	1046	30	2	2	CD
cord-001835-0s7ok4uw	1046	31	]	]	-RRB-
cord-001835-0s7ok4uw	1046	32	.	.	.
cord-001835-0s7ok4uw	1047	1	Particularly	particularly	RB
cord-001835-0s7ok4uw	1047	2	,	,	,
cord-001835-0s7ok4uw	1047	3	the	the	DT
cord-001835-0s7ok4uw	1047	4	modulation	modulation	NN
cord-001835-0s7ok4uw	1047	5	of	of	IN
cord-001835-0s7ok4uw	1047	6	reaction	reaction	NN
cord-001835-0s7ok4uw	1047	7	pathways	pathway	NNS
cord-001835-0s7ok4uw	1047	8	between	between	IN
cord-001835-0s7ok4uw	1047	9	folding	fold	VBG
cord-001835-0s7ok4uw	1047	10	states	state	NNS
cord-001835-0s7ok4uw	1047	11	,	,	,
cord-001835-0s7ok4uw	1047	12	offering	offer	VBG
cord-001835-0s7ok4uw	1047	13	possibilities	possibility	NNS
cord-001835-0s7ok4uw	1047	14	to	to	TO
cord-001835-0s7ok4uw	1047	15	control	control	VB
cord-001835-0s7ok4uw	1047	16	irreversibility	irreversibility	NN
cord-001835-0s7ok4uw	1047	17	in	in	IN
cord-001835-0s7ok4uw	1047	18	non	non	JJ
cord-001835-0s7ok4uw	1047	19	-	-	JJ
cord-001835-0s7ok4uw	1047	20	native	native	JJ
cord-001835-0s7ok4uw	1047	21	protein	protein	NN
cord-001835-0s7ok4uw	1047	22	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1047	23	[	[	-LRB-
cord-001835-0s7ok4uw	1047	24	2	2	CD
cord-001835-0s7ok4uw	1047	25	]	]	-RRB-
cord-001835-0s7ok4uw	1047	26	.	.	.
cord-001835-0s7ok4uw	1048	1	This	this	DT
cord-001835-0s7ok4uw	1048	2	has	have	VBZ
cord-001835-0s7ok4uw	1048	3	led	lead	VBN
cord-001835-0s7ok4uw	1048	4	us	-PRON-	PRP
cord-001835-0s7ok4uw	1048	5	to	to	TO
cord-001835-0s7ok4uw	1048	6	investigate	investigate	VB
cord-001835-0s7ok4uw	1048	7	the	the	DT
cord-001835-0s7ok4uw	1048	8	impact	impact	NN
cord-001835-0s7ok4uw	1048	9	of	of	IN
cord-001835-0s7ok4uw	1048	10	ILs	il	NNS
cord-001835-0s7ok4uw	1048	11	as	as	IN
cord-001835-0s7ok4uw	1048	12	co	co	NN
cord-001835-0s7ok4uw	1048	13	-	-	NNS
cord-001835-0s7ok4uw	1048	14	solvents	solvent	NNS
cord-001835-0s7ok4uw	1048	15	with	with	IN
cord-001835-0s7ok4uw	1048	16	the	the	DT
cord-001835-0s7ok4uw	1048	17	well	well	RB
cord-001835-0s7ok4uw	1048	18	-	-	HYPH
cord-001835-0s7ok4uw	1048	19	known	know	VBN
cord-001835-0s7ok4uw	1048	20	protein	protein	NN
cord-001835-0s7ok4uw	1048	21	denaturant	denaturant	JJ
cord-001835-0s7ok4uw	1048	22	urea	urea	NN
cord-001835-0s7ok4uw	1048	23	.	.	.
cord-001835-0s7ok4uw	1049	1	Urea	urea	NN
cord-001835-0s7ok4uw	1049	2	is	be	VBZ
cord-001835-0s7ok4uw	1049	3	considered	consider	VBN
cord-001835-0s7ok4uw	1049	4	to	to	TO
cord-001835-0s7ok4uw	1049	5	be	be	VB
cord-001835-0s7ok4uw	1049	6	a	a	DT
cord-001835-0s7ok4uw	1049	7	non	non	JJ
cord-001835-0s7ok4uw	1049	8	-	-	JJ
cord-001835-0s7ok4uw	1049	9	ionic	ionic	JJ
cord-001835-0s7ok4uw	1049	10	chaotrope	chaotrope	NN
cord-001835-0s7ok4uw	1049	11	disturbing	disturb	VBG
cord-001835-0s7ok4uw	1049	12	considerable	considerable	JJ
cord-001835-0s7ok4uw	1049	13	the	the	DT
cord-001835-0s7ok4uw	1049	14	grid	grid	NN
cord-001835-0s7ok4uw	1049	15	of	of	IN
cord-001835-0s7ok4uw	1049	16	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	1049	17	bonds	bond	NNS
cord-001835-0s7ok4uw	1049	18	with	with	IN
cord-001835-0s7ok4uw	1049	19	the	the	DT
cord-001835-0s7ok4uw	1049	20	protein	protein	NN
cord-001835-0s7ok4uw	1049	21	backbone	backbone	NN
cord-001835-0s7ok4uw	1049	22	.	.	.
cord-001835-0s7ok4uw	1050	1	Urea	urea	NN
cord-001835-0s7ok4uw	1050	2	interacts	interact	VBZ
cord-001835-0s7ok4uw	1050	3	preferentially	preferentially	RB
cord-001835-0s7ok4uw	1050	4	with	with	IN
cord-001835-0s7ok4uw	1050	5	the	the	DT
cord-001835-0s7ok4uw	1050	6	protein	protein	NN
cord-001835-0s7ok4uw	1050	7	surface	surface	NN
cord-001835-0s7ok4uw	1050	8	,	,	,
cord-001835-0s7ok4uw	1050	9	mainly	mainly	RB
cord-001835-0s7ok4uw	1050	10	apolar	apolar	JJ
cord-001835-0s7ok4uw	1050	11	residues	residue	NNS
cord-001835-0s7ok4uw	1050	12	and	and	CC
cord-001835-0s7ok4uw	1050	13	that	that	DT
cord-001835-0s7ok4uw	1050	14	dispersion	dispersion	NN
cord-001835-0s7ok4uw	1050	15	,	,	,
cord-001835-0s7ok4uw	1050	16	rather	rather	RB
cord-001835-0s7ok4uw	1050	17	than	than	IN
cord-001835-0s7ok4uw	1050	18	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	1050	19	interactions	interaction	NNS
cord-001835-0s7ok4uw	1050	20	,	,	,
cord-001835-0s7ok4uw	1050	21	is	be	VBZ
cord-001835-0s7ok4uw	1050	22	the	the	DT
cord-001835-0s7ok4uw	1050	23	main	main	JJ
cord-001835-0s7ok4uw	1050	24	energetic	energetic	JJ
cord-001835-0s7ok4uw	1050	25	contribution	contribution	NN
cord-001835-0s7ok4uw	1050	26	to	to	TO
cord-001835-0s7ok4uw	1050	27	explain	explain	VB
cord-001835-0s7ok4uw	1050	28	the	the	DT
cord-001835-0s7ok4uw	1050	29	stabilization	stabilization	NN
cord-001835-0s7ok4uw	1050	30	of	of	IN
cord-001835-0s7ok4uw	1050	31	the	the	DT
cord-001835-0s7ok4uw	1050	32	unfolded	unfold	VBN
cord-001835-0s7ok4uw	1050	33	state	state	NN
cord-001835-0s7ok4uw	1050	34	of	of	IN
cord-001835-0s7ok4uw	1050	35	the	the	DT
cord-001835-0s7ok4uw	1050	36	protein	protein	NN
cord-001835-0s7ok4uw	1050	37	and	and	CC
cord-001835-0s7ok4uw	1050	38	the	the	DT
cord-001835-0s7ok4uw	1050	39	irreversibility	irreversibility	NN
cord-001835-0s7ok4uw	1050	40	of	of	IN
cord-001835-0s7ok4uw	1050	41	the	the	DT
cord-001835-0s7ok4uw	1050	42	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1050	43	process	process	NN
cord-001835-0s7ok4uw	1050	44	in	in	IN
cord-001835-0s7ok4uw	1050	45	the	the	DT
cord-001835-0s7ok4uw	1050	46	presence	presence	NN
cord-001835-0s7ok4uw	1050	47	of	of	IN
cord-001835-0s7ok4uw	1050	48	urea	urea	NN
cord-001835-0s7ok4uw	1050	49	[	[	-LRB-
cord-001835-0s7ok4uw	1050	50	3	3	CD
cord-001835-0s7ok4uw	1050	51	]	]	-RRB-
cord-001835-0s7ok4uw	1050	52	.	.	.
cord-001835-0s7ok4uw	1050	53	 	 	_SP
cord-001835-0s7ok4uw	1051	1	A	a	DT
cord-001835-0s7ok4uw	1051	2	large	large	JJ
cord-001835-0s7ok4uw	1051	3	body	body	NN
cord-001835-0s7ok4uw	1051	4	of	of	IN
cord-001835-0s7ok4uw	1051	5	multidomain	multidomain	NN
cord-001835-0s7ok4uw	1051	6	protein	protein	NN
cord-001835-0s7ok4uw	1051	7	folding	folding	NN
cord-001835-0s7ok4uw	1051	8	work	work	NN
cord-001835-0s7ok4uw	1051	9	has	have	VBZ
cord-001835-0s7ok4uw	1051	10	been	be	VBN
cord-001835-0s7ok4uw	1051	11	devoted	devote	VBN
cord-001835-0s7ok4uw	1051	12	to	to	TO
cord-001835-0s7ok4uw	1051	13	study	study	VB
cord-001835-0s7ok4uw	1051	14	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	1051	15	proteins	protein	NNS
cord-001835-0s7ok4uw	1051	16	.	.	.
cord-001835-0s7ok4uw	1052	1	How	how	WRB
cord-001835-0s7ok4uw	1052	2	do	do	VBP
cord-001835-0s7ok4uw	1052	3	multidomain	multidomain	NNP
cord-001835-0s7ok4uw	1052	4	multimeric	multimeric	NNP
cord-001835-0s7ok4uw	1052	5	protein	protein	NN
cord-001835-0s7ok4uw	1052	6	fold	fold	NN
cord-001835-0s7ok4uw	1052	7	,	,	,
cord-001835-0s7ok4uw	1052	8	avoiding	avoid	VBG
cord-001835-0s7ok4uw	1052	9	accumulation	accumulation	NN
cord-001835-0s7ok4uw	1052	10	of	of	IN
cord-001835-0s7ok4uw	1052	11	stable	stable	JJ
cord-001835-0s7ok4uw	1052	12	intermediate	intermediate	NN
cord-001835-0s7ok4uw	1052	13	is	be	VBZ
cord-001835-0s7ok4uw	1052	14	yet	yet	RB
cord-001835-0s7ok4uw	1052	15	to	to	TO
cord-001835-0s7ok4uw	1052	16	be	be	VB
cord-001835-0s7ok4uw	1052	17	studied	study	VBN
cord-001835-0s7ok4uw	1052	18	in	in	IN
cord-001835-0s7ok4uw	1052	19	detail	detail	NN
cord-001835-0s7ok4uw	1052	20	.	.	.
cord-001835-0s7ok4uw	1053	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1053	2	present	present	JJ
cord-001835-0s7ok4uw	1053	3	study	study	NN
cord-001835-0s7ok4uw	1053	4	is	be	VBZ
cord-001835-0s7ok4uw	1053	5	focussed	focusse	VBN
cord-001835-0s7ok4uw	1053	6	on	on	IN
cord-001835-0s7ok4uw	1053	7	understanding	understand	VBG
cord-001835-0s7ok4uw	1053	8	the	the	DT
cord-001835-0s7ok4uw	1053	9	folding	folding	NN
cord-001835-0s7ok4uw	1053	10	and	and	CC
cord-001835-0s7ok4uw	1053	11	assembly	assembly	NN
cord-001835-0s7ok4uw	1053	12	of	of	IN
cord-001835-0s7ok4uw	1053	13	the	the	DT
cord-001835-0s7ok4uw	1053	14	domains	domain	NNS
cord-001835-0s7ok4uw	1053	15	of	of	IN
cord-001835-0s7ok4uw	1053	16	a	a	DT
cord-001835-0s7ok4uw	1053	17	homodimeric	homodimeric	NNP
cord-001835-0s7ok4uw	1053	18	L	L	NNP
cord-001835-0s7ok4uw	1053	19	-	-	HYPH
cord-001835-0s7ok4uw	1053	20	aspraginase	aspraginase	NNP
cord-001835-0s7ok4uw	1053	21	from	from	IN
cord-001835-0s7ok4uw	1053	22	a	a	DT
cord-001835-0s7ok4uw	1053	23	hyperthermophile	hyperthermophile	NNP
cord-001835-0s7ok4uw	1053	24	Pyrococcus	Pyrococcus	NNP
cord-001835-0s7ok4uw	1053	25	furiosus	furiosus	.
cord-001835-0s7ok4uw	1053	26	(	(	-LRB-
cord-001835-0s7ok4uw	1053	27	PfA	pfa	NN
cord-001835-0s7ok4uw	1053	28	)	)	-RRB-
cord-001835-0s7ok4uw	1053	29	.	.	.
cord-001835-0s7ok4uw	1054	1	Each	each	DT
cord-001835-0s7ok4uw	1054	2	monomer	monomer	NN
cord-001835-0s7ok4uw	1054	3	of	of	IN
cord-001835-0s7ok4uw	1054	4	PfA	pfa	NN
cord-001835-0s7ok4uw	1054	5	consists	consist	VBZ
cord-001835-0s7ok4uw	1054	6	of	of	IN
cord-001835-0s7ok4uw	1054	7	distinct	distinct	JJ
cord-001835-0s7ok4uw	1054	8	N	N	NNP
cord-001835-0s7ok4uw	1054	9	-	-	HYPH
cord-001835-0s7ok4uw	1054	10	and	and	CC
cord-001835-0s7ok4uw	1054	11	C	c	NN
cord-001835-0s7ok4uw	1054	12	-	-	HYPH
cord-001835-0s7ok4uw	1054	13	terminal	terminal	NN
cord-001835-0s7ok4uw	1054	14	domains	domain	NNS
cord-001835-0s7ok4uw	1054	15	(	(	-LRB-
cord-001835-0s7ok4uw	1054	16	NPfA	NPfA	NNP
cord-001835-0s7ok4uw	1054	17	and	and	CC
cord-001835-0s7ok4uw	1054	18	CPfA	CPfA	NNP
cord-001835-0s7ok4uw	1054	19	,	,	,
cord-001835-0s7ok4uw	1054	20	respectively	respectively	RB
cord-001835-0s7ok4uw	1054	21	)	)	-RRB-
cord-001835-0s7ok4uw	1054	22	,	,	,
cord-001835-0s7ok4uw	1054	23	connected	connect	VBN
cord-001835-0s7ok4uw	1054	24	by	by	IN
cord-001835-0s7ok4uw	1054	25	a	a	DT
cord-001835-0s7ok4uw	1054	26	linker	linker	NN
cord-001835-0s7ok4uw	1054	27	.	.	.
cord-001835-0s7ok4uw	1055	1	The	the	DT
cord-001835-0s7ok4uw	1055	2	folding	folding	NN
cord-001835-0s7ok4uw	1055	3	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1055	4	of	of	IN
cord-001835-0s7ok4uw	1055	5	each	each	DT
cord-001835-0s7ok4uw	1055	6	domain	domain	NN
cord-001835-0s7ok4uw	1055	7	with	with	IN
cord-001835-0s7ok4uw	1055	8	respect	respect	NN
cord-001835-0s7ok4uw	1055	9	to	to	IN
cord-001835-0s7ok4uw	1055	10	full	full	JJ
cord-001835-0s7ok4uw	1055	11	length	length	NN
cord-001835-0s7ok4uw	1055	12	protein	protein	NN
cord-001835-0s7ok4uw	1055	13	was	be	VBD
cord-001835-0s7ok4uw	1055	14	studied	study	VBN
cord-001835-0s7ok4uw	1055	15	by	by	IN
cord-001835-0s7ok4uw	1055	16	mutating	mutate	VBG
cord-001835-0s7ok4uw	1055	17	one	one	CD
cord-001835-0s7ok4uw	1055	18	out	out	IN
cord-001835-0s7ok4uw	1055	19	of	of	IN
cord-001835-0s7ok4uw	1055	20	two	two	CD
cord-001835-0s7ok4uw	1055	21	tryptophans	tryptophan	NNS
cord-001835-0s7ok4uw	1055	22	,	,	,
cord-001835-0s7ok4uw	1055	23	one	one	CD
cord-001835-0s7ok4uw	1055	24	in	in	IN
cord-001835-0s7ok4uw	1055	25	each	each	DT
cord-001835-0s7ok4uw	1055	26	domain	domain	NN
cord-001835-0s7ok4uw	1055	27	.	.	.
cord-001835-0s7ok4uw	1056	1	Domains	domain	NNS
cord-001835-0s7ok4uw	1056	2	were	be	VBD
cord-001835-0s7ok4uw	1056	3	purified	purify	VBN
cord-001835-0s7ok4uw	1056	4	and	and	CC
cord-001835-0s7ok4uw	1056	5	studied	study	VBN
cord-001835-0s7ok4uw	1056	6	individually	individually	RB
cord-001835-0s7ok4uw	1056	7	to	to	TO
cord-001835-0s7ok4uw	1056	8	obtain	obtain	VB
cord-001835-0s7ok4uw	1056	9	parallel	parallel	JJ
cord-001835-0s7ok4uw	1056	10	account	account	NN
cord-001835-0s7ok4uw	1056	11	of	of	IN
cord-001835-0s7ok4uw	1056	12	the	the	DT
cord-001835-0s7ok4uw	1056	13	folding	folding	NN
cord-001835-0s7ok4uw	1056	14	of	of	IN
cord-001835-0s7ok4uw	1056	15	each	each	DT
cord-001835-0s7ok4uw	1056	16	domain	domain	NN
cord-001835-0s7ok4uw	1056	17	in	in	IN
cord-001835-0s7ok4uw	1056	18	isolation	isolation	NN
cord-001835-0s7ok4uw	1056	19	.	.	.
cord-001835-0s7ok4uw	1057	1	Subunit	Subunit	NNP
cord-001835-0s7ok4uw	1057	2	assembly	assembly	NN
cord-001835-0s7ok4uw	1057	3	was	be	VBD
cord-001835-0s7ok4uw	1057	4	studied	study	VBN
cord-001835-0s7ok4uw	1057	5	by	by	IN
cord-001835-0s7ok4uw	1057	6	analytical	analytical	JJ
cord-001835-0s7ok4uw	1057	7	size	size	NN
cord-001835-0s7ok4uw	1057	8	exclusion	exclusion	NN
cord-001835-0s7ok4uw	1057	9	chromatography	chromatography	NN
cord-001835-0s7ok4uw	1057	10	(	(	-LRB-
cord-001835-0s7ok4uw	1057	11	SEC	SEC	NNP
cord-001835-0s7ok4uw	1057	12	)	)	-RRB-
cord-001835-0s7ok4uw	1057	13	,	,	,
cord-001835-0s7ok4uw	1057	14	Multiangle	Multiangle	NNP
cord-001835-0s7ok4uw	1057	15	light	light	NN
cord-001835-0s7ok4uw	1057	16	scattering	scattering	NN
cord-001835-0s7ok4uw	1057	17	and	and	CC
cord-001835-0s7ok4uw	1057	18	functional	functional	JJ
cord-001835-0s7ok4uw	1057	19	activity	activity	NN
cord-001835-0s7ok4uw	1057	20	.	.	.
cord-001835-0s7ok4uw	1058	1	Through	through	IN
cord-001835-0s7ok4uw	1058	2	far	far	JJ
cord-001835-0s7ok4uw	1058	3	UV	uv	NN
cord-001835-0s7ok4uw	1058	4	CD	cd	NN
cord-001835-0s7ok4uw	1058	5	,	,	,
cord-001835-0s7ok4uw	1058	6	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	1058	7	Trp	trp	NN
cord-001835-0s7ok4uw	1058	8	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1058	9	and	and	CC
cord-001835-0s7ok4uw	1058	10	SEC	SEC	NNP
cord-001835-0s7ok4uw	1058	11	,	,	,
cord-001835-0s7ok4uw	1058	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	1058	13	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	1058	14	that	that	DT
cord-001835-0s7ok4uw	1058	15	domain	domain	NN
cord-001835-0s7ok4uw	1058	16	folding	folding	NN
cord-001835-0s7ok4uw	1058	17	and	and	CC
cord-001835-0s7ok4uw	1058	18	subunit	subunit	NNP
cord-001835-0s7ok4uw	1058	19	association	association	NNP
cord-001835-0s7ok4uw	1058	20	were	be	VBD
cord-001835-0s7ok4uw	1058	21	intimately	intimately	RB
cord-001835-0s7ok4uw	1058	22	linked	link	VBN
cord-001835-0s7ok4uw	1058	23	in	in	IN
cord-001835-0s7ok4uw	1058	24	full	full	JJ
cord-001835-0s7ok4uw	1058	25	length	length	NN
cord-001835-0s7ok4uw	1059	1	PfA.	PfA.	NNP
cord-001835-0s7ok4uw	1060	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	1060	2	,	,	,
cord-001835-0s7ok4uw	1060	3	en	en	IN
cord-001835-0s7ok4uw	1060	4	route	route	NN
cord-001835-0s7ok4uw	1060	5	to	to	IN
cord-001835-0s7ok4uw	1060	6	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1060	7	folding	folding	NN
cord-001835-0s7ok4uw	1060	8	there	there	EX
cord-001835-0s7ok4uw	1060	9	was	be	VBD
cord-001835-0s7ok4uw	1060	10	complete	complete	JJ
cord-001835-0s7ok4uw	1060	11	absence	absence	NN
cord-001835-0s7ok4uw	1060	12	of	of	IN
cord-001835-0s7ok4uw	1060	13	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	1060	14	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	1060	15	as	as	IN
cord-001835-0s7ok4uw	1060	16	probed	probe	VBN
cord-001835-0s7ok4uw	1060	17	by	by	IN
cord-001835-0s7ok4uw	1060	18	ANS	ANS	NNP
cord-001835-0s7ok4uw	1060	19	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1060	20	.	.	.
cord-001835-0s7ok4uw	1061	1	Folding	fold	VBG
cord-001835-0s7ok4uw	1061	2	of	of	IN
cord-001835-0s7ok4uw	1061	3	NPfA	NPfA	NNP
cord-001835-0s7ok4uw	1061	4	was	be	VBD
cord-001835-0s7ok4uw	1061	5	highly	highly	RB
cord-001835-0s7ok4uw	1061	6	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	1061	7	and	and	CC
cord-001835-0s7ok4uw	1061	8	,	,	,
cord-001835-0s7ok4uw	1061	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	1061	10	provides	provide	VBZ
cord-001835-0s7ok4uw	1061	11	interacting	interact	VBG
cord-001835-0s7ok4uw	1061	12	surfaces	surface	NNS
cord-001835-0s7ok4uw	1061	13	for	for	IN
cord-001835-0s7ok4uw	1061	14	CPfA	cpfa	CD
cord-001835-0s7ok4uw	1061	15	to	to	TO
cord-001835-0s7ok4uw	1061	16	fold	fold	VB
cord-001835-0s7ok4uw	1061	17	and	and	CC
cord-001835-0s7ok4uw	1061	18	also	also	RB
cord-001835-0s7ok4uw	1061	19	facilitates	facilitate	VBZ
cord-001835-0s7ok4uw	1061	20	subunit	subunit	NN
cord-001835-0s7ok4uw	1061	21	assembly	assembly	NN
cord-001835-0s7ok4uw	1061	22	.	.	.
cord-001835-0s7ok4uw	1062	1	The	the	DT
cord-001835-0s7ok4uw	1062	2	folding	fold	VBG
cord-001835-0s7ok4uw	1062	3	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	1062	4	of	of	IN
cord-001835-0s7ok4uw	1062	5	isolated	isolate	VBN
cord-001835-0s7ok4uw	1062	6	domains	domain	NNS
cord-001835-0s7ok4uw	1062	7	was	be	VBD
cord-001835-0s7ok4uw	1062	8	very	very	RB
cord-001835-0s7ok4uw	1062	9	less	less	RBR
cord-001835-0s7ok4uw	1062	10	compared	compare	VBN
cord-001835-0s7ok4uw	1062	11	to	to	IN
cord-001835-0s7ok4uw	1062	12	the	the	DT
cord-001835-0s7ok4uw	1062	13	folding	fold	VBG
cord-001835-0s7ok4uw	1062	14	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	1062	15	of	of	IN
cord-001835-0s7ok4uw	1062	16	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1062	17	full	full	JJ
cord-001835-0s7ok4uw	1062	18	length	length	NN
cord-001835-0s7ok4uw	1062	19	counterparts	counterpart	NNS
cord-001835-0s7ok4uw	1062	20	,	,	,
cord-001835-0s7ok4uw	1062	21	as	as	IN
cord-001835-0s7ok4uw	1062	22	indicated	indicate	VBN
cord-001835-0s7ok4uw	1062	23	by	by	IN
cord-001835-0s7ok4uw	1062	24	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	1062	25	m	m	CD
cord-001835-0s7ok4uw	1062	26	values	value	NNS
cord-001835-0s7ok4uw	1062	27	.	.	.
cord-001835-0s7ok4uw	1063	1	To	to	IN
cord-001835-0s7ok4uw	1063	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1063	3	surprise	surprise	NN
cord-001835-0s7ok4uw	1063	4	,	,	,
cord-001835-0s7ok4uw	1063	5	during	during	IN
cord-001835-0s7ok4uw	1063	6	pH	pH	NNP
cord-001835-0s7ok4uw	1063	7	induced	induce	VBN
cord-001835-0s7ok4uw	1063	8	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1063	9	,	,	,
cord-001835-0s7ok4uw	1063	10	at	at	IN
cord-001835-0s7ok4uw	1063	11	pH	pH	NNP
cord-001835-0s7ok4uw	1063	12	2	2	CD
cord-001835-0s7ok4uw	1063	13	and	and	CC
cord-001835-0s7ok4uw	1063	14	13	13	CD
cord-001835-0s7ok4uw	1063	15	,	,	,
cord-001835-0s7ok4uw	1063	16	the	the	DT
cord-001835-0s7ok4uw	1063	17	dimer	dimer	NN
cord-001835-0s7ok4uw	1063	18	dissociates	dissociate	VBZ
cord-001835-0s7ok4uw	1063	19	into	into	IN
cord-001835-0s7ok4uw	1063	20	highly	highly	RB
cord-001835-0s7ok4uw	1063	21	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	1063	22	folded	fold	VBN
cord-001835-0s7ok4uw	1063	23	monomers	monomer	NNS
cord-001835-0s7ok4uw	1063	24	which	which	WDT
cord-001835-0s7ok4uw	1063	25	readily	readily	RB
cord-001835-0s7ok4uw	1063	26	underwent	undergo	VBD
cord-001835-0s7ok4uw	1063	27	amyloidogenesis	amyloidogenesis	NN
cord-001835-0s7ok4uw	1063	28	.	.	.
cord-001835-0s7ok4uw	1064	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1064	2	showed	show	VBD
cord-001835-0s7ok4uw	1064	3	that	that	IN
cord-001835-0s7ok4uw	1064	4	at	at	IN
cord-001835-0s7ok4uw	1064	5	such	such	JJ
cord-001835-0s7ok4uw	1064	6	extreme	extreme	JJ
cord-001835-0s7ok4uw	1064	7	conditions	condition	NNS
cord-001835-0s7ok4uw	1064	8	,	,	,
cord-001835-0s7ok4uw	1064	9	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	1064	10	in	in	IN
cord-001835-0s7ok4uw	1064	11	folding	folding	NN
cord-001835-0s7ok4uw	1064	12	process	process	NN
cord-001835-0s7ok4uw	1064	13	in	in	IN
cord-001835-0s7ok4uw	1064	14	multidomain	multidomain	NNP
cord-001835-0s7ok4uw	1064	15	multimeric	multimeric	NNP
cord-001835-0s7ok4uw	1064	16	protein	protein	NN
cord-001835-0s7ok4uw	1064	17	is	be	VBZ
cord-001835-0s7ok4uw	1064	18	not	not	RB
cord-001835-0s7ok4uw	1064	19	solely	solely	RB
cord-001835-0s7ok4uw	1064	20	governed	govern	VBN
cord-001835-0s7ok4uw	1064	21	by	by	IN
cord-001835-0s7ok4uw	1064	22	the	the	DT
cord-001835-0s7ok4uw	1064	23	folding	folding	NN
cord-001835-0s7ok4uw	1064	24	of	of	IN
cord-001835-0s7ok4uw	1064	25	individual	individual	JJ
cord-001835-0s7ok4uw	1064	26	domains	domain	NNS
cord-001835-0s7ok4uw	1064	27	,	,	,
cord-001835-0s7ok4uw	1064	28	rather	rather	RB
cord-001835-0s7ok4uw	1064	29	by	by	IN
cord-001835-0s7ok4uw	1064	30	concomitant	concomitant	JJ
cord-001835-0s7ok4uw	1064	31	folding	folding	NN
cord-001835-0s7ok4uw	1064	32	and	and	CC
cord-001835-0s7ok4uw	1064	33	association	association	NN
cord-001835-0s7ok4uw	1064	34	of	of	IN
cord-001835-0s7ok4uw	1064	35	domains	domain	NNS
cord-001835-0s7ok4uw	1064	36	directly	directly	RB
cord-001835-0s7ok4uw	1064	37	into	into	IN
cord-001835-0s7ok4uw	1064	38	a	a	DT
cord-001835-0s7ok4uw	1064	39	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	1064	40	structure	structure	NN
cord-001835-0s7ok4uw	1064	41	.	.	.
cord-001835-0s7ok4uw	1065	1	In	in	IN
cord-001835-0s7ok4uw	1065	2	other	other	JJ
cord-001835-0s7ok4uw	1065	3	case	case	NN
cord-001835-0s7ok4uw	1065	4	,	,	,
cord-001835-0s7ok4uw	1065	5	where	where	WRB
cord-001835-0s7ok4uw	1065	6	subunit	subunit	NN
cord-001835-0s7ok4uw	1065	7	folding	folding	NN
cord-001835-0s7ok4uw	1065	8	occurred	occur	VBD
cord-001835-0s7ok4uw	1065	9	prior	prior	RB
cord-001835-0s7ok4uw	1065	10	to	to	IN
cord-001835-0s7ok4uw	1065	11	association	association	NN
cord-001835-0s7ok4uw	1065	12	,	,	,
cord-001835-0s7ok4uw	1065	13	protein	protein	NN
cord-001835-0s7ok4uw	1065	14	readily	readily	RB
cord-001835-0s7ok4uw	1065	15	underwent	undergo	VBD
cord-001835-0s7ok4uw	1065	16	extensive	extensive	JJ
cord-001835-0s7ok4uw	1065	17	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1065	18	.	.	.
cord-001835-0s7ok4uw	1066	1	GroEL	groel	NN
cord-001835-0s7ok4uw	1066	2	assisted	assist	VBN
cord-001835-0s7ok4uw	1066	3	folding	folding	NN
cord-001835-0s7ok4uw	1066	4	of	of	IN
cord-001835-0s7ok4uw	1066	5	multiple	multiple	JJ
cord-001835-0s7ok4uw	1066	6	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1066	7	proteins	protein	NNS
cord-001835-0s7ok4uw	1066	8	simultaneously	simultaneously	RB
cord-001835-0s7ok4uw	1066	9	over	over	RB
cord-001835-0s7ok4uw	1066	10	-	-	HYPH
cord-001835-0s7ok4uw	1066	11	expressed	express	VBN
cord-001835-0s7ok4uw	1066	12	in	in	IN
cord-001835-0s7ok4uw	1066	13	E.coli	E.coli	NNP
cord-001835-0s7ok4uw	1066	14	Megha	Megha	NNP
cord-001835-0s7ok4uw	1066	15	Goyal	Goyal	NNP
cord-001835-0s7ok4uw	1066	16	1	1	CD
cord-001835-0s7ok4uw	1066	17	,	,	,
cord-001835-0s7ok4uw	1066	18	Tapan	Tapan	NNP
cord-001835-0s7ok4uw	1066	19	Kumar	Kumar	NNP
cord-001835-0s7ok4uw	1066	20	Chaudhuri	Chaudhuri	NNP
cord-001835-0s7ok4uw	1066	21	1	1	CD
cord-001835-0s7ok4uw	1066	22	1	1	CD
cord-001835-0s7ok4uw	1066	23	Aggregation	aggregation	NN
cord-001835-0s7ok4uw	1066	24	prone	prone	JJ
cord-001835-0s7ok4uw	1066	25	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1066	26	proteins	protein	NNS
cord-001835-0s7ok4uw	1066	27	very	very	RB
cord-001835-0s7ok4uw	1066	28	often	often	RB
cord-001835-0s7ok4uw	1066	29	form	form	VBP
cord-001835-0s7ok4uw	1066	30	inclusion	inclusion	NN
cord-001835-0s7ok4uw	1066	31	bodies	body	NNS
cord-001835-0s7ok4uw	1066	32	and	and	CC
cord-001835-0s7ok4uw	1066	33	also	also	RB
cord-001835-0s7ok4uw	1066	34	exhibits	exhibit	VBZ
cord-001835-0s7ok4uw	1066	35	poor	poor	JJ
cord-001835-0s7ok4uw	1066	36	yield	yield	NN
cord-001835-0s7ok4uw	1066	37	of	of	IN
cord-001835-0s7ok4uw	1066	38	functional	functional	JJ
cord-001835-0s7ok4uw	1066	39	protein	protein	NN
cord-001835-0s7ok4uw	1066	40	during	during	IN
cord-001835-0s7ok4uw	1066	41	in	in	IN
cord-001835-0s7ok4uw	1066	42	vitro	vitro	FW
cord-001835-0s7ok4uw	1066	43	refolding	refolde	VBG
cord-001835-0s7ok4uw	1066	44	process	process	NN
cord-001835-0s7ok4uw	1066	45	from	from	IN
cord-001835-0s7ok4uw	1066	46	chemically	chemically	RB
cord-001835-0s7ok4uw	1066	47	denatured	denature	VBN
cord-001835-0s7ok4uw	1066	48	form	form	NN
cord-001835-0s7ok4uw	1066	49	.	.	.
cord-001835-0s7ok4uw	1067	1	Bacterial	bacterial	JJ
cord-001835-0s7ok4uw	1067	2	chaperonin	chaperonin	NNS
cord-001835-0s7ok4uw	1067	3	GroEL	groel	NN
cord-001835-0s7ok4uw	1067	4	provides	provide	VBZ
cord-001835-0s7ok4uw	1067	5	folding	fold	VBG
cord-001835-0s7ok4uw	1067	6	assistance	assistance	NN
cord-001835-0s7ok4uw	1067	7	to	to	IN
cord-001835-0s7ok4uw	1067	8	several	several	JJ
cord-001835-0s7ok4uw	1067	9	proteins	protein	NNS
cord-001835-0s7ok4uw	1067	10	,	,	,
cord-001835-0s7ok4uw	1067	11	when	when	WRB
cord-001835-0s7ok4uw	1067	12	over	over	RB
cord-001835-0s7ok4uw	1067	13	-	-	HYPH
cord-001835-0s7ok4uw	1067	14	expressed	express	VBN
cord-001835-0s7ok4uw	1067	15	with	with	IN
cord-001835-0s7ok4uw	1067	16	one	one	CD
cord-001835-0s7ok4uw	1067	17	of	of	IN
cord-001835-0s7ok4uw	1067	18	the	the	DT
cord-001835-0s7ok4uw	1067	19	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1067	20	proteins	protein	NNS
cord-001835-0s7ok4uw	1067	21	.	.	.
cord-001835-0s7ok4uw	1068	1	There	there	EX
cord-001835-0s7ok4uw	1068	2	are	be	VBP
cord-001835-0s7ok4uw	1068	3	instances	instance	NNS
cord-001835-0s7ok4uw	1068	4	that	that	WDT
cord-001835-0s7ok4uw	1068	5	GroEL	groel	VBP
cord-001835-0s7ok4uw	1068	6	in	in	IN
cord-001835-0s7ok4uw	1068	7	presence	presence	NN
cord-001835-0s7ok4uw	1068	8	of	of	IN
cord-001835-0s7ok4uw	1068	9	few	few	JJ
cord-001835-0s7ok4uw	1068	10	other	other	JJ
cord-001835-0s7ok4uw	1068	11	co	co	NNS
cord-001835-0s7ok4uw	1068	12	-	-	JJ
cord-001835-0s7ok4uw	1068	13	expressed	express	VBN
cord-001835-0s7ok4uw	1068	14	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	1068	15	like	like	IN
cord-001835-0s7ok4uw	1068	16	DnaJ	DnaJ	NNP
cord-001835-0s7ok4uw	1068	17	,	,	,
cord-001835-0s7ok4uw	1068	18	DnaK	DnaK	NNP
cord-001835-0s7ok4uw	1068	19	etc	etc	FW
cord-001835-0s7ok4uw	1068	20	provides	provide	VBZ
cord-001835-0s7ok4uw	1068	21	better	well	JJR
cord-001835-0s7ok4uw	1068	22	yield	yield	NN
cord-001835-0s7ok4uw	1068	23	of	of	IN
cord-001835-0s7ok4uw	1068	24	folded	folded	JJ
cord-001835-0s7ok4uw	1068	25	protein	protein	NN
cord-001835-0s7ok4uw	1068	26	during	during	IN
cord-001835-0s7ok4uw	1068	27	homologous	homologous	JJ
cord-001835-0s7ok4uw	1068	28	and	and	CC
cord-001835-0s7ok4uw	1068	29	heterologous	heterologous	JJ
cord-001835-0s7ok4uw	1068	30	expression	expression	NN
cord-001835-0s7ok4uw	1068	31	.	.	.
cord-001835-0s7ok4uw	1069	1	Considering	consider	VBG
cord-001835-0s7ok4uw	1069	2	the	the	DT
cord-001835-0s7ok4uw	1069	3	ongoing	ongoing	JJ
cord-001835-0s7ok4uw	1069	4	events	event	NNS
cord-001835-0s7ok4uw	1069	5	in	in	IN
cord-001835-0s7ok4uw	1069	6	the	the	DT
cord-001835-0s7ok4uw	1069	7	cells	cell	NNS
cord-001835-0s7ok4uw	1069	8	,	,	,
cord-001835-0s7ok4uw	1069	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	1069	10	is	be	VBZ
cord-001835-0s7ok4uw	1069	11	known	know	VBN
cord-001835-0s7ok4uw	1069	12	that	that	IN
cord-001835-0s7ok4uw	1069	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	1069	14	chaperone	chaperone	NN
cord-001835-0s7ok4uw	1069	15	GroEL	groel	NN
cord-001835-0s7ok4uw	1069	16	assists	assist	VBZ
cord-001835-0s7ok4uw	1069	17	in	in	IN
cord-001835-0s7ok4uw	1069	18	the	the	DT
cord-001835-0s7ok4uw	1069	19	folding	folding	NN
cord-001835-0s7ok4uw	1069	20	of	of	IN
cord-001835-0s7ok4uw	1069	21	various	various	JJ
cord-001835-0s7ok4uw	1069	22	proteins	protein	NNS
cord-001835-0s7ok4uw	1069	23	in	in	IN
cord-001835-0s7ok4uw	1069	24	the	the	DT
cord-001835-0s7ok4uw	1069	25	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	1069	26	.	.	.
cord-001835-0s7ok4uw	1070	1	Hence	hence	RB
cord-001835-0s7ok4uw	1070	2	attempt	attempt	VB
cord-001835-0s7ok4uw	1070	3	to	to	TO
cord-001835-0s7ok4uw	1070	4	fold	fold	VB
cord-001835-0s7ok4uw	1070	5	multiple	multiple	JJ
cord-001835-0s7ok4uw	1070	6	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1070	7	proteins	protein	NNS
cord-001835-0s7ok4uw	1070	8	over	over	RB
cord-001835-0s7ok4uw	1070	9	-	-	HYPH
cord-001835-0s7ok4uw	1070	10	expressing	express	VBG
cord-001835-0s7ok4uw	1070	11	simultaneously	simultaneously	RB
cord-001835-0s7ok4uw	1070	12	with	with	IN
cord-001835-0s7ok4uw	1070	13	the	the	DT
cord-001835-0s7ok4uw	1070	14	co	co	NN
cord-001835-0s7ok4uw	1070	15	-	-	NN
cord-001835-0s7ok4uw	1070	16	expression	expression	NN
cord-001835-0s7ok4uw	1070	17	of	of	IN
cord-001835-0s7ok4uw	1070	18	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	1070	19	can	can	MD
cord-001835-0s7ok4uw	1070	20	be	be	VB
cord-001835-0s7ok4uw	1070	21	worth	worth	JJ
cord-001835-0s7ok4uw	1070	22	trying	try	VBG
cord-001835-0s7ok4uw	1070	23	.	.	.
cord-001835-0s7ok4uw	1071	1	This	this	DT
cord-001835-0s7ok4uw	1071	2	approach	approach	NN
cord-001835-0s7ok4uw	1071	3	may	may	MD
cord-001835-0s7ok4uw	1071	4	cut	cut	VB
cord-001835-0s7ok4uw	1071	5	down	down	RP
cord-001835-0s7ok4uw	1071	6	various	various	JJ
cord-001835-0s7ok4uw	1071	7	complexities	complexity	NNS
cord-001835-0s7ok4uw	1071	8	in	in	IN
cord-001835-0s7ok4uw	1071	9	the	the	DT
cord-001835-0s7ok4uw	1071	10	functional	functional	JJ
cord-001835-0s7ok4uw	1071	11	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1071	12	protein	protein	NN
cord-001835-0s7ok4uw	1071	13	preparation	preparation	NN
cord-001835-0s7ok4uw	1071	14	,	,	,
cord-001835-0s7ok4uw	1071	15	including	include	VBG
cord-001835-0s7ok4uw	1071	16	time	time	NN
cord-001835-0s7ok4uw	1071	17	and	and	CC
cord-001835-0s7ok4uw	1071	18	effective	effective	JJ
cord-001835-0s7ok4uw	1071	19	cost	cost	NN
cord-001835-0s7ok4uw	1071	20	.	.	.
cord-001835-0s7ok4uw	1072	1	Keeping	keep	VBG
cord-001835-0s7ok4uw	1072	2	this	this	DT
cord-001835-0s7ok4uw	1072	3	view	view	NN
cord-001835-0s7ok4uw	1072	4	in	in	IN
cord-001835-0s7ok4uw	1072	5	mind	mind	NN
cord-001835-0s7ok4uw	1072	6	,	,	,
cord-001835-0s7ok4uw	1072	7	folding	fold	VBG
cord-001835-0s7ok4uw	1072	8	of	of	IN
cord-001835-0s7ok4uw	1072	9	two	two	CD
cord-001835-0s7ok4uw	1072	10	simultaneously	simultaneously	RB
cord-001835-0s7ok4uw	1072	11	expressed	express	VBD
cord-001835-0s7ok4uw	1072	12	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1072	13	prone	prone	JJ
cord-001835-0s7ok4uw	1072	14	proteins	protein	NNS
cord-001835-0s7ok4uw	1072	15	,	,	,
cord-001835-0s7ok4uw	1072	16	69	69	CD
cord-001835-0s7ok4uw	1072	17	kDa	kDa	NNS
cord-001835-0s7ok4uw	1072	18	E.coli	e.coli	NN
cord-001835-0s7ok4uw	1072	19	maltodextrin	maltodextrin	NN
cord-001835-0s7ok4uw	1072	20	glucosidase	glucosidase	NN
cord-001835-0s7ok4uw	1072	21	(	(	-LRB-
cord-001835-0s7ok4uw	1072	22	MalZ	MalZ	NNP
cord-001835-0s7ok4uw	1072	23	)	)	-RRB-
cord-001835-0s7ok4uw	1072	24	and	and	CC
cord-001835-0s7ok4uw	1072	25	82	82	CD
cord-001835-0s7ok4uw	1072	26	kDa	kDa	NNS
cord-001835-0s7ok4uw	1072	27	yeast	yeast	NN
cord-001835-0s7ok4uw	1072	28	mitochondrial	mitochondrial	NN
cord-001835-0s7ok4uw	1072	29	aconitase	aconitase	NNP
cord-001835-0s7ok4uw	1072	30	have	have	VBP
cord-001835-0s7ok4uw	1072	31	been	be	VBN
cord-001835-0s7ok4uw	1072	32	investigated	investigate	VBN
cord-001835-0s7ok4uw	1072	33	with	with	IN
cord-001835-0s7ok4uw	1072	34	the	the	DT
cord-001835-0s7ok4uw	1072	35	co	co	NN
cord-001835-0s7ok4uw	1072	36	-	-	NN
cord-001835-0s7ok4uw	1072	37	expression	expression	NN
cord-001835-0s7ok4uw	1072	38	of	of	IN
cord-001835-0s7ok4uw	1072	39	GroEL	GroEL	NNP
cord-001835-0s7ok4uw	1072	40	and	and	CC
cord-001835-0s7ok4uw	1072	41	GroES	GroES	NNP
cord-001835-0s7ok4uw	1072	42	in	in	IN
cord-001835-0s7ok4uw	1072	43	E.coli	e.coli	NN
cord-001835-0s7ok4uw	1072	44	cytosol	cytosol	NN
cord-001835-0s7ok4uw	1072	45	.	.	.
cord-001835-0s7ok4uw	1073	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1073	2	has	have	VBZ
cord-001835-0s7ok4uw	1073	3	been	be	VBN
cord-001835-0s7ok4uw	1073	4	previously	previously	RB
cord-001835-0s7ok4uw	1073	5	reported	report	VBN
cord-001835-0s7ok4uw	1073	6	that	that	IN
cord-001835-0s7ok4uw	1073	7	both	both	CC
cord-001835-0s7ok4uw	1073	8	the	the	DT
cord-001835-0s7ok4uw	1073	9	chosen	choose	VBN
cord-001835-0s7ok4uw	1073	10	proteins	protein	NNS
cord-001835-0s7ok4uw	1073	11	undergo	undergo	VBP
cord-001835-0s7ok4uw	1073	12	co	co	VBN
cord-001835-0s7ok4uw	1073	13	-	-	VBD
cord-001835-0s7ok4uw	1073	14	expressed	express	VBN
cord-001835-0s7ok4uw	1073	15	GroEL	GroEL	NNP
cord-001835-0s7ok4uw	1073	16	-	-	HYPH
cord-001835-0s7ok4uw	1073	17	GroES	GroES	NNP
cord-001835-0s7ok4uw	1073	18	assisted	assist	VBN
cord-001835-0s7ok4uw	1073	19	folding	folding	NN
cord-001835-0s7ok4uw	1073	20	in	in	IN
cord-001835-0s7ok4uw	1073	21	E.coli	e.coli	NN
cord-001835-0s7ok4uw	1073	22	cytosol	cytosol	NN
cord-001835-0s7ok4uw	1073	23	,	,	,
cord-001835-0s7ok4uw	1073	24	when	when	WRB
cord-001835-0s7ok4uw	1073	25	they	-PRON-	PRP
cord-001835-0s7ok4uw	1073	26	over	over	RB
cord-001835-0s7ok4uw	1073	27	-	-	HYPH
cord-001835-0s7ok4uw	1073	28	express	express	NN
cord-001835-0s7ok4uw	1073	29	alone	alone	RB
cord-001835-0s7ok4uw	1073	30	.	.	.
cord-001835-0s7ok4uw	1074	1	In	in	IN
cord-001835-0s7ok4uw	1074	2	this	this	DT
cord-001835-0s7ok4uw	1074	3	study	study	NN
cord-001835-0s7ok4uw	1074	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	1074	5	have	have	VBP
cord-001835-0s7ok4uw	1074	6	optimized	optimize	VBN
cord-001835-0s7ok4uw	1074	7	the	the	DT
cord-001835-0s7ok4uw	1074	8	overexpression	overexpression	NN
cord-001835-0s7ok4uw	1074	9	of	of	IN
cord-001835-0s7ok4uw	1074	10	MalZ	MalZ	NNP
cord-001835-0s7ok4uw	1074	11	and	and	CC
cord-001835-0s7ok4uw	1074	12	aconitase	aconitase	NNP
cord-001835-0s7ok4uw	1074	13	simultaneously	simultaneously	RB
cord-001835-0s7ok4uw	1074	14	in	in	IN
cord-001835-0s7ok4uw	1074	15	E.coli	E.coli	NNS
cord-001835-0s7ok4uw	1074	16	.	.	.
cord-001835-0s7ok4uw	1075	1	Further	further	JJ
cord-001835-0s7ok4uw	1075	2	optimisation	optimisation	NN
cord-001835-0s7ok4uw	1075	3	was	be	VBD
cord-001835-0s7ok4uw	1075	4	carried	carry	VBN
cord-001835-0s7ok4uw	1075	5	out	out	RP
cord-001835-0s7ok4uw	1075	6	to	to	TO
cord-001835-0s7ok4uw	1075	7	coexpress	coexpress	VB
cord-001835-0s7ok4uw	1075	8	GroEL	GroEL	NNP
cord-001835-0s7ok4uw	1075	9	along	along	RP
cord-001835-0s7ok4uw	1075	10	with	with	IN
cord-001835-0s7ok4uw	1075	11	MalZ	MalZ	NNP
cord-001835-0s7ok4uw	1075	12	and	and	CC
cord-001835-0s7ok4uw	1075	13	aconitase	aconitase	NNP
cord-001835-0s7ok4uw	1075	14	.	.	.
cord-001835-0s7ok4uw	1076	1	Based	base	VBN
cord-001835-0s7ok4uw	1076	2	on	on	IN
cord-001835-0s7ok4uw	1076	3	the	the	DT
cord-001835-0s7ok4uw	1076	4	basic	basic	JJ
cord-001835-0s7ok4uw	1076	5	philosophy	philosophy	NN
cord-001835-0s7ok4uw	1076	6	that	that	IN
cord-001835-0s7ok4uw	1076	7	soluble	soluble	JJ
cord-001835-0s7ok4uw	1076	8	protein	protein	NN
cord-001835-0s7ok4uw	1076	9	mainly	mainly	RB
cord-001835-0s7ok4uw	1076	10	contains	contain	VBZ
cord-001835-0s7ok4uw	1076	11	folded	fold	VBN
cord-001835-0s7ok4uw	1076	12	fraction	fraction	NN
cord-001835-0s7ok4uw	1076	13	,	,	,
cord-001835-0s7ok4uw	1076	14	the	the	DT
cord-001835-0s7ok4uw	1076	15	event	event	NN
cord-001835-0s7ok4uw	1076	16	of	of	IN
cord-001835-0s7ok4uw	1076	17	GroEL	GroEL	NNP
cord-001835-0s7ok4uw	1076	18	/	/	SYM
cord-001835-0s7ok4uw	1076	19	ES	ES	NNP
cord-001835-0s7ok4uw	1076	20	assisted	assist	VBN
cord-001835-0s7ok4uw	1076	21	folding	folding	NN
cord-001835-0s7ok4uw	1076	22	of	of	IN
cord-001835-0s7ok4uw	1076	23	simultaneously	simultaneously	RB
cord-001835-0s7ok4uw	1076	24	overexpressed	overexpresse	VBN
cord-001835-0s7ok4uw	1076	25	proteins	protein	NNS
cord-001835-0s7ok4uw	1076	26	,	,	,
cord-001835-0s7ok4uw	1076	27	MalZ	MalZ	NNP
cord-001835-0s7ok4uw	1076	28	and	and	CC
cord-001835-0s7ok4uw	1076	29	aconitase	aconitase	NNP
cord-001835-0s7ok4uw	1076	30	was	be	VBD
cord-001835-0s7ok4uw	1076	31	monitored	monitor	VBN
cord-001835-0s7ok4uw	1076	32	through	through	IN
cord-001835-0s7ok4uw	1076	33	the	the	DT
cord-001835-0s7ok4uw	1076	34	attainment	attainment	NN
cord-001835-0s7ok4uw	1076	35	of	of	IN
cord-001835-0s7ok4uw	1076	36	soluble	soluble	JJ
cord-001835-0s7ok4uw	1076	37	proteins	protein	NNS
cord-001835-0s7ok4uw	1076	38	under	under	IN
cord-001835-0s7ok4uw	1076	39	various	various	JJ
cord-001835-0s7ok4uw	1076	40	sets	set	NNS
cord-001835-0s7ok4uw	1076	41	of	of	IN
cord-001835-0s7ok4uw	1076	42	conditions	condition	NNS
cord-001835-0s7ok4uw	1076	43	such	such	JJ
cord-001835-0s7ok4uw	1076	44	as	as	IN
cord-001835-0s7ok4uw	1076	45	temperature	temperature	NN
cord-001835-0s7ok4uw	1076	46	.	.	.
cord-001835-0s7ok4uw	1077	1	The	the	DT
cord-001835-0s7ok4uw	1077	2	major	major	JJ
cord-001835-0s7ok4uw	1077	3	outcome	outcome	NN
cord-001835-0s7ok4uw	1077	4	of	of	IN
cord-001835-0s7ok4uw	1077	5	the	the	DT
cord-001835-0s7ok4uw	1077	6	present	present	JJ
cord-001835-0s7ok4uw	1077	7	study	study	NN
cord-001835-0s7ok4uw	1077	8	is	be	VBZ
cord-001835-0s7ok4uw	1077	9	that	that	IN
cord-001835-0s7ok4uw	1077	10	,	,	,
cord-001835-0s7ok4uw	1077	11	with	with	IN
cord-001835-0s7ok4uw	1077	12	the	the	DT
cord-001835-0s7ok4uw	1077	13	GroEL	GroEL	NNP
cord-001835-0s7ok4uw	1077	14	-	-	HYPH
cord-001835-0s7ok4uw	1077	15	GroES	GroES	NNP
cord-001835-0s7ok4uw	1077	16	assistance	assistance	NN
cord-001835-0s7ok4uw	1077	17	,	,	,
cord-001835-0s7ok4uw	1077	18	the	the	DT
cord-001835-0s7ok4uw	1077	19	yield	yield	NN
cord-001835-0s7ok4uw	1077	20	of	of	IN
cord-001835-0s7ok4uw	1077	21	soluble	soluble	JJ
cord-001835-0s7ok4uw	1077	22	proteins	protein	NNS
cord-001835-0s7ok4uw	1077	23	(	(	-LRB-
cord-001835-0s7ok4uw	1077	24	MalZ	MalZ	NNP
cord-001835-0s7ok4uw	1077	25	and	and	CC
cord-001835-0s7ok4uw	1077	26	aconitase	aconitase	NNP
cord-001835-0s7ok4uw	1077	27	)	)	-RRB-
cord-001835-0s7ok4uw	1077	28	together	together	RB
cord-001835-0s7ok4uw	1077	29	constitutes	constitute	VBZ
cord-001835-0s7ok4uw	1077	30	higher	high	JJR
cord-001835-0s7ok4uw	1077	31	percentage	percentage	NN
cord-001835-0s7ok4uw	1077	32	of	of	IN
cord-001835-0s7ok4uw	1077	33	folded	folded	JJ
cord-001835-0s7ok4uw	1077	34	protein	protein	NN
cord-001835-0s7ok4uw	1077	35	in	in	IN
cord-001835-0s7ok4uw	1077	36	contrast	contrast	NN
cord-001835-0s7ok4uw	1077	37	to	to	IN
cord-001835-0s7ok4uw	1077	38	the	the	DT
cord-001835-0s7ok4uw	1077	39	percent	percent	NN
cord-001835-0s7ok4uw	1077	40	yield	yield	NN
cord-001835-0s7ok4uw	1077	41	when	when	WRB
cord-001835-0s7ok4uw	1077	42	a	a	DT
cord-001835-0s7ok4uw	1077	43	single	single	JJ
cord-001835-0s7ok4uw	1077	44	protein	protein	NN
cord-001835-0s7ok4uw	1077	45	was	be	VBD
cord-001835-0s7ok4uw	1077	46	overexpressed	overexpresse	VBN
cord-001835-0s7ok4uw	1077	47	.	.	.
cord-001835-0s7ok4uw	1078	1	Significance	significance	NN
cord-001835-0s7ok4uw	1078	2	of	of	IN
cord-001835-0s7ok4uw	1078	3	this	this	DT
cord-001835-0s7ok4uw	1078	4	type	type	NN
cord-001835-0s7ok4uw	1078	5	of	of	IN
cord-001835-0s7ok4uw	1078	6	study	study	NN
cord-001835-0s7ok4uw	1078	7	relies	rely	VBZ
cord-001835-0s7ok4uw	1078	8	on	on	IN
cord-001835-0s7ok4uw	1078	9	the	the	DT
cord-001835-0s7ok4uw	1078	10	fact	fact	NN
cord-001835-0s7ok4uw	1078	11	that	that	IN
cord-001835-0s7ok4uw	1078	12	the	the	DT
cord-001835-0s7ok4uw	1078	13	cells	cell	NNS
cord-001835-0s7ok4uw	1078	14	can	can	MD
cord-001835-0s7ok4uw	1078	15	over	over	IN
cord-001835-0s7ok4uw	1078	16	-	-	HYPH
cord-001835-0s7ok4uw	1078	17	produce	produce	NN
cord-001835-0s7ok4uw	1078	18	higher	high	JJR
cord-001835-0s7ok4uw	1078	19	amount	amount	NN
cord-001835-0s7ok4uw	1078	20	of	of	IN
cord-001835-0s7ok4uw	1078	21	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1078	22	proteins	protein	NNS
cord-001835-0s7ok4uw	1078	23	,	,	,
cord-001835-0s7ok4uw	1078	24	when	when	WRB
cord-001835-0s7ok4uw	1078	25	multiple	multiple	JJ
cord-001835-0s7ok4uw	1078	26	over	over	JJ
cord-001835-0s7ok4uw	1078	27	-	-	HYPH
cord-001835-0s7ok4uw	1078	28	expression	expression	NN
cord-001835-0s7ok4uw	1078	29	takes	take	VBZ
cord-001835-0s7ok4uw	1078	30	place	place	NN
cord-001835-0s7ok4uw	1078	31	.	.	.
cord-001835-0s7ok4uw	1079	1	Not	not	RB
cord-001835-0s7ok4uw	1079	2	only	only	RB
cord-001835-0s7ok4uw	1079	3	pushing	push	VBG
cord-001835-0s7ok4uw	1079	4	up	up	RP
cord-001835-0s7ok4uw	1079	5	cell	cell	NN
cord-001835-0s7ok4uw	1079	6	's	's	POS
cord-001835-0s7ok4uw	1079	7	capability	capability	NN
cord-001835-0s7ok4uw	1079	8	of	of	IN
cord-001835-0s7ok4uw	1079	9	over	over	IN
cord-001835-0s7ok4uw	1079	10	-	-	HYPH
cord-001835-0s7ok4uw	1079	11	expression	expression	NN
cord-001835-0s7ok4uw	1079	12	,	,	,
cord-001835-0s7ok4uw	1079	13	co	co	NN
cord-001835-0s7ok4uw	1079	14	-	-	NN
cord-001835-0s7ok4uw	1079	15	expression	expression	NN
cord-001835-0s7ok4uw	1079	16	of	of	IN
cord-001835-0s7ok4uw	1079	17	GroEL	GroEL	NNP
cord-001835-0s7ok4uw	1079	18	and	and	CC
cord-001835-0s7ok4uw	1079	19	GroES	GroES	NNP
cord-001835-0s7ok4uw	1079	20	efficiently	efficiently	RB
cord-001835-0s7ok4uw	1079	21	assists	assist	VBZ
cord-001835-0s7ok4uw	1079	22	in	in	IN
cord-001835-0s7ok4uw	1079	23	the	the	DT
cord-001835-0s7ok4uw	1079	24	folding	folding	NN
cord-001835-0s7ok4uw	1079	25	of	of	IN
cord-001835-0s7ok4uw	1079	26	multiple	multiple	JJ
cord-001835-0s7ok4uw	1079	27	proteins	protein	NNS
cord-001835-0s7ok4uw	1079	28	simultaneously	simultaneously	RB
cord-001835-0s7ok4uw	1079	29	over	over	RB
cord-001835-0s7ok4uw	1079	30	-	-	HYPH
cord-001835-0s7ok4uw	1079	31	expressed	express	VBN
cord-001835-0s7ok4uw	1079	32	in	in	IN
cord-001835-0s7ok4uw	1079	33	E.coli	E.coli	NNS
cord-001835-0s7ok4uw	1079	34	.	.	.
cord-001835-0s7ok4uw	1080	1	Amyloid	amyloid	NN
cord-001835-0s7ok4uw	1080	2	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1080	3	associated	associate	VBN
cord-001835-0s7ok4uw	1080	4	with	with	IN
cord-001835-0s7ok4uw	1080	5	serious	serious	JJ
cord-001835-0s7ok4uw	1080	6	diseases	disease	NNS
cord-001835-0s7ok4uw	1080	7	including	include	VBG
cord-001835-0s7ok4uw	1080	8	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	1080	9	's	's	POS
cord-001835-0s7ok4uw	1080	10	,	,	,
cord-001835-0s7ok4uw	1080	11	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	1080	12	's	's	POS
cord-001835-0s7ok4uw	1080	13	,	,	,
cord-001835-0s7ok4uw	1080	14	and	and	CC
cord-001835-0s7ok4uw	1080	15	prion	prion	NN
cord-001835-0s7ok4uw	1080	16	diseases	disease	NNS
cord-001835-0s7ok4uw	1080	17	promoted	promote	VBD
cord-001835-0s7ok4uw	1080	18	the	the	DT
cord-001835-0s7ok4uw	1080	19	challenge	challenge	NN
cord-001835-0s7ok4uw	1080	20	of	of	IN
cord-001835-0s7ok4uw	1080	21	studying	study	VBG
cord-001835-0s7ok4uw	1080	22	protein	protein	NN
cord-001835-0s7ok4uw	1080	23	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	1080	24	,	,	,
cord-001835-0s7ok4uw	1080	25	leading	lead	VBG
cord-001835-0s7ok4uw	1080	26	to	to	IN
cord-001835-0s7ok4uw	1080	27	the	the	DT
cord-001835-0s7ok4uw	1080	28	development	development	NN
cord-001835-0s7ok4uw	1080	29	of	of	IN
cord-001835-0s7ok4uw	1080	30	amyloid	amyloid	JJ
cord-001835-0s7ok4uw	1080	31	structural	structural	JJ
cord-001835-0s7ok4uw	1080	32	biology	biology	NN
cord-001835-0s7ok4uw	1080	33	.	.	.
cord-001835-0s7ok4uw	1081	1	Amyloid	amyloid	NN
cord-001835-0s7ok4uw	1081	2	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1081	3	form	form	VBP
cord-001835-0s7ok4uw	1081	4	in	in	IN
cord-001835-0s7ok4uw	1081	5	supersaturated	supersaturated	JJ
cord-001835-0s7ok4uw	1081	6	solutions	solution	NNS
cord-001835-0s7ok4uw	1081	7	via	via	IN
cord-001835-0s7ok4uw	1081	8	a	a	DT
cord-001835-0s7ok4uw	1081	9	nucleation	nucleation	NN
cord-001835-0s7ok4uw	1081	10	and	and	CC
cord-001835-0s7ok4uw	1081	11	growth	growth	NN
cord-001835-0s7ok4uw	1081	12	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1081	13	.	.	.
cord-001835-0s7ok4uw	1082	1	Although	although	IN
cord-001835-0s7ok4uw	1082	2	the	the	DT
cord-001835-0s7ok4uw	1082	3	structural	structural	JJ
cord-001835-0s7ok4uw	1082	4	features	feature	NNS
cord-001835-0s7ok4uw	1082	5	of	of	IN
cord-001835-0s7ok4uw	1082	6	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1082	7	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1082	8	have	have	VBP
cord-001835-0s7ok4uw	1082	9	become	become	VBN
cord-001835-0s7ok4uw	1082	10	increasingly	increasingly	RB
cord-001835-0s7ok4uw	1082	11	clearer	clear	JJR
cord-001835-0s7ok4uw	1082	12	,	,	,
cord-001835-0s7ok4uw	1082	13	knowledge	knowledge	NN
cord-001835-0s7ok4uw	1082	14	on	on	IN
cord-001835-0s7ok4uw	1082	15	the	the	DT
cord-001835-0s7ok4uw	1082	16	thermodynamics	thermodynamic	NNS
cord-001835-0s7ok4uw	1082	17	of	of	IN
cord-001835-0s7ok4uw	1082	18	fibrillation	fibrillation	NN
cord-001835-0s7ok4uw	1082	19	is	be	VBZ
cord-001835-0s7ok4uw	1082	20	limited	limit	VBN
cord-001835-0s7ok4uw	1082	21	.	.	.
cord-001835-0s7ok4uw	1083	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1083	2	,	,	,
cord-001835-0s7ok4uw	1083	3	protein	protein	NN
cord-001835-0s7ok4uw	1083	4	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1083	5	is	be	VBZ
cord-001835-0s7ok4uw	1083	6	not	not	RB
cord-001835-0s7ok4uw	1083	7	a	a	DT
cord-001835-0s7ok4uw	1083	8	target	target	NN
cord-001835-0s7ok4uw	1083	9	of	of	IN
cord-001835-0s7ok4uw	1083	10	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	1083	11	,	,	,
cord-001835-0s7ok4uw	1083	12	one	one	CD
cord-001835-0s7ok4uw	1083	13	of	of	IN
cord-001835-0s7ok4uw	1083	14	the	the	DT
cord-001835-0s7ok4uw	1083	15	most	most	RBS
cord-001835-0s7ok4uw	1083	16	powerful	powerful	JJ
cord-001835-0s7ok4uw	1083	17	approaches	approach	NNS
cord-001835-0s7ok4uw	1083	18	used	use	VBN
cord-001835-0s7ok4uw	1083	19	to	to	TO
cord-001835-0s7ok4uw	1083	20	study	study	VB
cord-001835-0s7ok4uw	1083	21	proteins	protein	NNS
cord-001835-0s7ok4uw	1083	22	.	.	.
cord-001835-0s7ok4uw	1084	1	Here	here	RB
cord-001835-0s7ok4uw	1084	2	,	,	,
cord-001835-0s7ok4uw	1084	3	with	with	IN
cord-001835-0s7ok4uw	1084	4	b2-microglobulin	b2-microglobulin	NNP
cord-001835-0s7ok4uw	1084	5	,	,	,
cord-001835-0s7ok4uw	1084	6	a	a	DT
cord-001835-0s7ok4uw	1084	7	protein	protein	NN
cord-001835-0s7ok4uw	1084	8	responsible	responsible	JJ
cord-001835-0s7ok4uw	1084	9	for	for	IN
cord-001835-0s7ok4uw	1084	10	dialysis	dialysis	NN
cord-001835-0s7ok4uw	1084	11	-	-	HYPH
cord-001835-0s7ok4uw	1084	12	related	relate	VBN
cord-001835-0s7ok4uw	1084	13	amyloidosis	amyloidosis	NN
cord-001835-0s7ok4uw	1084	14	,	,	,
cord-001835-0s7ok4uw	1084	15	we	-PRON-	PRP
cord-001835-0s7ok4uw	1084	16	show	show	VBP
cord-001835-0s7ok4uw	1084	17	direct	direct	JJ
cord-001835-0s7ok4uw	1084	18	heat	heat	NN
cord-001835-0s7ok4uw	1084	19	measurements	measurement	NNS
cord-001835-0s7ok4uw	1084	20	of	of	IN
cord-001835-0s7ok4uw	1084	21	the	the	DT
cord-001835-0s7ok4uw	1084	22	formation	formation	NN
cord-001835-0s7ok4uw	1084	23	of	of	IN
cord-001835-0s7ok4uw	1084	24	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1084	25	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1084	26	using	use	VBG
cord-001835-0s7ok4uw	1084	27	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	1084	28	titration	titration	NN
cord-001835-0s7ok4uw	1084	29	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	1084	30	(	(	-LRB-
cord-001835-0s7ok4uw	1084	31	ITC	ITC	NNP
cord-001835-0s7ok4uw	1084	32	)	)	-RRB-
cord-001835-0s7ok4uw	1084	33	.	.	.
cord-001835-0s7ok4uw	1085	1	The	the	DT
cord-001835-0s7ok4uw	1085	2	spontaneous	spontaneous	JJ
cord-001835-0s7ok4uw	1085	3	fibrillation	fibrillation	NN
cord-001835-0s7ok4uw	1085	4	after	after	IN
cord-001835-0s7ok4uw	1085	5	a	a	DT
cord-001835-0s7ok4uw	1085	6	lag	lag	NN
cord-001835-0s7ok4uw	1085	7	phase	phase	NN
cord-001835-0s7ok4uw	1085	8	was	be	VBD
cord-001835-0s7ok4uw	1085	9	accompanied	accompany	VBN
cord-001835-0s7ok4uw	1085	10	by	by	IN
cord-001835-0s7ok4uw	1085	11	exothermic	exothermic	JJ
cord-001835-0s7ok4uw	1085	12	heat	heat	NN
cord-001835-0s7ok4uw	1085	13	.	.	.
cord-001835-0s7ok4uw	1086	1	The	the	DT
cord-001835-0s7ok4uw	1086	2	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1086	3	parameters	parameter	NNS
cord-001835-0s7ok4uw	1086	4	of	of	IN
cord-001835-0s7ok4uw	1086	5	fibrillation	fibrillation	NN
cord-001835-0s7ok4uw	1086	6	obtained	obtain	VBN
cord-001835-0s7ok4uw	1086	7	under	under	IN
cord-001835-0s7ok4uw	1086	8	various	various	JJ
cord-001835-0s7ok4uw	1086	9	protein	protein	NN
cord-001835-0s7ok4uw	1086	10	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1086	11	and	and	CC
cord-001835-0s7ok4uw	1086	12	temperatures	temperature	NNS
cord-001835-0s7ok4uw	1086	13	were	be	VBD
cord-001835-0s7ok4uw	1086	14	consistent	consistent	JJ
cord-001835-0s7ok4uw	1086	15	with	with	IN
cord-001835-0s7ok4uw	1086	16	the	the	DT
cord-001835-0s7ok4uw	1086	17	main	main	JJ
cord-001835-0s7ok4uw	1086	18	-	-	HYPH
cord-001835-0s7ok4uw	1086	19	chain	chain	NN
cord-001835-0s7ok4uw	1086	20	dominated	dominate	VBD
cord-001835-0s7ok4uw	1086	21	structural	structural	JJ
cord-001835-0s7ok4uw	1086	22	model	model	NN
cord-001835-0s7ok4uw	1086	23	of	of	IN
cord-001835-0s7ok4uw	1086	24	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1086	25	,	,	,
cord-001835-0s7ok4uw	1086	26	in	in	IN
cord-001835-0s7ok4uw	1086	27	which	which	WDT
cord-001835-0s7ok4uw	1086	28	overall	overall	JJ
cord-001835-0s7ok4uw	1086	29	packing	packing	NN
cord-001835-0s7ok4uw	1086	30	was	be	VBD
cord-001835-0s7ok4uw	1086	31	less	less	JJR
cord-001835-0s7ok4uw	1086	32	than	than	IN
cord-001835-0s7ok4uw	1086	33	that	that	DT
cord-001835-0s7ok4uw	1086	34	of	of	IN
cord-001835-0s7ok4uw	1086	35	the	the	DT
cord-001835-0s7ok4uw	1086	36	native	native	JJ
cord-001835-0s7ok4uw	1086	37	structures	structure	NNS
cord-001835-0s7ok4uw	1086	38	.	.	.
cord-001835-0s7ok4uw	1087	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1087	2	also	also	RB
cord-001835-0s7ok4uw	1087	3	characterized	characterize	VBD
cord-001835-0s7ok4uw	1087	4	the	the	DT
cord-001835-0s7ok4uw	1087	5	thermodynamics	thermodynamic	NNS
cord-001835-0s7ok4uw	1087	6	of	of	IN
cord-001835-0s7ok4uw	1087	7	amorphous	amorphous	JJ
cord-001835-0s7ok4uw	1087	8	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1087	9	,	,	,
cord-001835-0s7ok4uw	1087	10	enabling	enable	VBG
cord-001835-0s7ok4uw	1087	11	the	the	DT
cord-001835-0s7ok4uw	1087	12	comparison	comparison	NN
cord-001835-0s7ok4uw	1087	13	of	of	IN
cord-001835-0s7ok4uw	1087	14	protein	protein	NN
cord-001835-0s7ok4uw	1087	15	folding	folding	NN
cord-001835-0s7ok4uw	1087	16	,	,	,
cord-001835-0s7ok4uw	1087	17	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1087	18	fibrillation	fibrillation	NN
cord-001835-0s7ok4uw	1087	19	,	,	,
cord-001835-0s7ok4uw	1087	20	and	and	CC
cord-001835-0s7ok4uw	1087	21	amorphous	amorphous	JJ
cord-001835-0s7ok4uw	1087	22	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1087	23	.	.	.
cord-001835-0s7ok4uw	1088	1	In	in	IN
cord-001835-0s7ok4uw	1088	2	order	order	NN
cord-001835-0s7ok4uw	1088	3	to	to	TO
cord-001835-0s7ok4uw	1088	4	obtain	obtain	VB
cord-001835-0s7ok4uw	1088	5	general	general	JJ
cord-001835-0s7ok4uw	1088	6	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1088	7	properties	property	NNS
cord-001835-0s7ok4uw	1088	8	of	of	IN
cord-001835-0s7ok4uw	1088	9	protein	protein	NN
cord-001835-0s7ok4uw	1088	10	aggregations	aggregation	NNS
cord-001835-0s7ok4uw	1088	11	,	,	,
cord-001835-0s7ok4uw	1088	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	1088	13	further	further	RB
cord-001835-0s7ok4uw	1088	14	investigated	investigate	VBD
cord-001835-0s7ok4uw	1088	15	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1088	16	of	of	IN
cord-001835-0s7ok4uw	1088	17	glucagon	glucagon	NN
cord-001835-0s7ok4uw	1088	18	and	and	CC
cord-001835-0s7ok4uw	1088	19	insulin	insulin	NN
cord-001835-0s7ok4uw	1088	20	,	,	,
cord-001835-0s7ok4uw	1088	21	two	two	CD
cord-001835-0s7ok4uw	1088	22	of	of	IN
cord-001835-0s7ok4uw	1088	23	the	the	DT
cord-001835-0s7ok4uw	1088	24	most	most	RBS
cord-001835-0s7ok4uw	1088	25	famous	famous	JJ
cord-001835-0s7ok4uw	1088	26	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	1088	27	peptide	peptide	JJ
cord-001835-0s7ok4uw	1088	28	hormones	hormone	NNS
cord-001835-0s7ok4uw	1088	29	,	,	,
cord-001835-0s7ok4uw	1088	30	using	use	VBG
cord-001835-0s7ok4uw	1088	31	ITC	ITC	NNP
cord-001835-0s7ok4uw	1088	32	.	.	.
cord-001835-0s7ok4uw	1089	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1089	2	also	also	RB
cord-001835-0s7ok4uw	1089	3	observed	observe	VBD
cord-001835-0s7ok4uw	1089	4	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	1089	5	heat	heat	NN
cord-001835-0s7ok4uw	1089	6	of	of	IN
cord-001835-0s7ok4uw	1089	7	spontaneous	spontaneous	JJ
cord-001835-0s7ok4uw	1089	8	amyloid	amyloid	JJ
cord-001835-0s7ok4uw	1089	9	fibrillation	fibrillation	NN
cord-001835-0s7ok4uw	1089	10	of	of	IN
cord-001835-0s7ok4uw	1089	11	both	both	DT
cord-001835-0s7ok4uw	1089	12	proteins	protein	NNS
cord-001835-0s7ok4uw	1089	13	after	after	IN
cord-001835-0s7ok4uw	1089	14	a	a	DT
cord-001835-0s7ok4uw	1089	15	lag	lag	NN
cord-001835-0s7ok4uw	1089	16	time	time	NN
cord-001835-0s7ok4uw	1089	17	.	.	.
cord-001835-0s7ok4uw	1090	1	Taken	take	VBN
cord-001835-0s7ok4uw	1090	2	all	all	DT
cord-001835-0s7ok4uw	1090	3	together	together	RB
cord-001835-0s7ok4uw	1090	4	,	,	,
cord-001835-0s7ok4uw	1090	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1090	6	showed	show	VBD
cord-001835-0s7ok4uw	1090	7	that	that	IN
cord-001835-0s7ok4uw	1090	8	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1090	9	studies	study	NNS
cord-001835-0s7ok4uw	1090	10	on	on	IN
cord-001835-0s7ok4uw	1090	11	amyloid	amyloid	JJ
cord-001835-0s7ok4uw	1090	12	fibrillation	fibrillation	NN
cord-001835-0s7ok4uw	1090	13	and	and	CC
cord-001835-0s7ok4uw	1090	14	amorphous	amorphous	JJ
cord-001835-0s7ok4uw	1090	15	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1090	16	were	be	VBD
cord-001835-0s7ok4uw	1090	17	indeed	indeed	RB
cord-001835-0s7ok4uw	1090	18	possible	possible	JJ
cord-001835-0s7ok4uw	1090	19	by	by	IN
cord-001835-0s7ok4uw	1090	20	means	mean	NNS
cord-001835-0s7ok4uw	1090	21	of	of	IN
cord-001835-0s7ok4uw	1090	22	ITC	ITC	NNP
cord-001835-0s7ok4uw	1090	23	-	-	HYPH
cord-001835-0s7ok4uw	1090	24	based	base	VBN
cord-001835-0s7ok4uw	1090	25	qualitative	qualitative	JJ
cord-001835-0s7ok4uw	1090	26	and	and	CC
cord-001835-0s7ok4uw	1090	27	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	1090	28	calorimetric	calorimetric	JJ
cord-001835-0s7ok4uw	1090	29	analyses	analysis	NNS
cord-001835-0s7ok4uw	1090	30	.	.	.
cord-001835-0s7ok4uw	1091	1	ITC	ITC	NNP
cord-001835-0s7ok4uw	1091	2	will	will	MD
cord-001835-0s7ok4uw	1091	3	become	become	VB
cord-001835-0s7ok4uw	1091	4	a	a	DT
cord-001835-0s7ok4uw	1091	5	promising	promising	JJ
cord-001835-0s7ok4uw	1091	6	approach	approach	NN
cord-001835-0s7ok4uw	1091	7	for	for	IN
cord-001835-0s7ok4uw	1091	8	clarifying	clarify	VBG
cord-001835-0s7ok4uw	1091	9	the	the	DT
cord-001835-0s7ok4uw	1091	10	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1091	11	properties	property	NNS
cord-001835-0s7ok4uw	1091	12	of	of	IN
cord-001835-0s7ok4uw	1091	13	protein	protein	NN
cord-001835-0s7ok4uw	1091	14	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	1091	15	.	.	.
cord-001835-0s7ok4uw	1092	1	The	the	DT
cord-001835-0s7ok4uw	1092	2	more	more	JJR
cord-001835-0s7ok4uw	1092	3	case	case	NN
cord-001835-0s7ok4uw	1092	4	studies	study	NNS
cord-001835-0s7ok4uw	1092	5	are	be	VBP
cord-001835-0s7ok4uw	1092	6	required	require	VBN
cord-001835-0s7ok4uw	1092	7	toward	toward	IN
cord-001835-0s7ok4uw	1092	8	the	the	DT
cord-001835-0s7ok4uw	1092	9	establishment	establishment	NN
cord-001835-0s7ok4uw	1092	10	of	of	IN
cord-001835-0s7ok4uw	1092	11	thermodynamics	thermodynamic	NNS
cord-001835-0s7ok4uw	1092	12	of	of	IN
cord-001835-0s7ok4uw	1092	13	protein	protein	NN
cord-001835-0s7ok4uw	1092	14	misfolding	misfolding	NN
cord-001835-0s7ok4uw	1092	15	and	and	CC
cord-001835-0s7ok4uw	1092	16	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1092	17	When	when	WRB
cord-001835-0s7ok4uw	1092	18	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	1092	19	proteins	protein	NNS
cord-001835-0s7ok4uw	1092	20	are	be	VBP
cord-001835-0s7ok4uw	1092	21	,	,	,
cord-001835-0s7ok4uw	1092	22	for	for	IN
cord-001835-0s7ok4uw	1092	23	any	any	DT
cord-001835-0s7ok4uw	1092	24	reason	reason	NN
cord-001835-0s7ok4uw	1092	25	,	,	,
cord-001835-0s7ok4uw	1092	26	exposed	expose	VBN
cord-001835-0s7ok4uw	1092	27	to	to	IN
cord-001835-0s7ok4uw	1092	28	the	the	DT
cord-001835-0s7ok4uw	1092	29	cytosol	cytosol	NN
cord-001835-0s7ok4uw	1092	30	they	-PRON-	PRP
cord-001835-0s7ok4uw	1092	31	are	be	VBP
cord-001835-0s7ok4uw	1092	32	rapidly	rapidly	RB
cord-001835-0s7ok4uw	1092	33	captured	capture	VBN
cord-001835-0s7ok4uw	1092	34	by	by	IN
cord-001835-0s7ok4uw	1092	35	protective	protective	JJ
cord-001835-0s7ok4uw	1092	36	complexes	complex	NNS
cord-001835-0s7ok4uw	1092	37	which	which	WDT
cord-001835-0s7ok4uw	1092	38	shield	shield	VBP
cord-001835-0s7ok4uw	1092	39	them	-PRON-	PRP
cord-001835-0s7ok4uw	1092	40	from	from	IN
cord-001835-0s7ok4uw	1092	41	the	the	DT
cord-001835-0s7ok4uw	1092	42	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	1092	43	surroundings	surrounding	NNS
cord-001835-0s7ok4uw	1092	44	and	and	CC
cord-001835-0s7ok4uw	1092	45	decide	decide	VB
cord-001835-0s7ok4uw	1092	46	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1092	47	fate	fate	NN
cord-001835-0s7ok4uw	1092	48	(	(	-LRB-
cord-001835-0s7ok4uw	1092	49	by	by	IN
cord-001835-0s7ok4uw	1092	50	either	either	DT
cord-001835-0s7ok4uw	1092	51	targeting	target	VBG
cord-001835-0s7ok4uw	1092	52	them	-PRON-	PRP
cord-001835-0s7ok4uw	1092	53	to	to	IN
cord-001835-0s7ok4uw	1092	54	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1092	55	correct	correct	JJ
cord-001835-0s7ok4uw	1092	56	membrane	membrane	NN
cord-001835-0s7ok4uw	1092	57	homes	home	NNS
cord-001835-0s7ok4uw	1092	58	or	or	CC
cord-001835-0s7ok4uw	1092	59	marking	mark	VBG
cord-001835-0s7ok4uw	1092	60	them	-PRON-	PRP
cord-001835-0s7ok4uw	1092	61	for	for	IN
cord-001835-0s7ok4uw	1092	62	degradation	degradation	NN
cord-001835-0s7ok4uw	1092	63	by	by	IN
cord-001835-0s7ok4uw	1092	64	the	the	DT
cord-001835-0s7ok4uw	1092	65	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	1092	66	/	/	SYM
cord-001835-0s7ok4uw	1092	67	proteasome	proteasome	NN
cord-001835-0s7ok4uw	1092	68	system	system	NN
cord-001835-0s7ok4uw	1092	69	)	)	-RRB-
cord-001835-0s7ok4uw	1092	70	.	.	.
cord-001835-0s7ok4uw	1093	1	The	the	DT
cord-001835-0s7ok4uw	1093	2	BAG6	BAG6	NNP
cord-001835-0s7ok4uw	1093	3	holdase	holdase	NNP
cord-001835-0s7ok4uw	1093	4	is	be	VBZ
cord-001835-0s7ok4uw	1093	5	a	a	DT
cord-001835-0s7ok4uw	1093	6	heterotrimeric	heterotrimeric	NN
cord-001835-0s7ok4uw	1093	7	protein	protein	NN
cord-001835-0s7ok4uw	1093	8	complex	complex	NN
cord-001835-0s7ok4uw	1093	9	,	,	,
cord-001835-0s7ok4uw	1093	10	comprising	comprise	VBG
cord-001835-0s7ok4uw	1093	11	BAG6	BAG6	NNP
cord-001835-0s7ok4uw	1093	12	,	,	,
cord-001835-0s7ok4uw	1093	13	UBL4a	UBL4a	NNP
cord-001835-0s7ok4uw	1093	14	and	and	CC
cord-001835-0s7ok4uw	1093	15	TRC35	TRC35	NNP
cord-001835-0s7ok4uw	1093	16	,	,	,
cord-001835-0s7ok4uw	1093	17	which	which	WDT
cord-001835-0s7ok4uw	1093	18	works	work	VBZ
cord-001835-0s7ok4uw	1093	19	closely	closely	RB
cord-001835-0s7ok4uw	1093	20	with	with	IN
cord-001835-0s7ok4uw	1093	21	the	the	DT
cord-001835-0s7ok4uw	1093	22	cochaperone	cochaperone	NNP
cord-001835-0s7ok4uw	1093	23	SGTA	SGTA	NNP
cord-001835-0s7ok4uw	1093	24	to	to	IN
cord-001835-0s7ok4uw	1093	25	triage	triage	NN
cord-001835-0s7ok4uw	1093	26	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	1093	27	proteins	protein	NNS
cord-001835-0s7ok4uw	1093	28	and	and	CC
cord-001835-0s7ok4uw	1093	29	pass	pass	VB
cord-001835-0s7ok4uw	1093	30	them	-PRON-	PRP
cord-001835-0s7ok4uw	1093	31	along	along	IN
cord-001835-0s7ok4uw	1093	32	the	the	DT
cord-001835-0s7ok4uw	1093	33	appropriate	appropriate	JJ
cord-001835-0s7ok4uw	1093	34	pathway	pathway	NN
cord-001835-0s7ok4uw	1093	35	.	.	.
cord-001835-0s7ok4uw	1094	1	SGTA	SGTA	NNP
cord-001835-0s7ok4uw	1094	2	also	also	RB
cord-001835-0s7ok4uw	1094	3	interacts	interact	VBZ
cord-001835-0s7ok4uw	1094	4	with	with	IN
cord-001835-0s7ok4uw	1094	5	viral	viral	JJ
cord-001835-0s7ok4uw	1094	6	proteins	protein	NNS
cord-001835-0s7ok4uw	1094	7	and	and	CC
cord-001835-0s7ok4uw	1094	8	hormone	hormone	NN
cord-001835-0s7ok4uw	1094	9	receptors	receptor	NNS
cord-001835-0s7ok4uw	1094	10	and	and	CC
cord-001835-0s7ok4uw	1094	11	is	be	VBZ
cord-001835-0s7ok4uw	1094	12	upregulated	upregulate	VBN
cord-001835-0s7ok4uw	1094	13	in	in	IN
cord-001835-0s7ok4uw	1094	14	numerous	numerous	JJ
cord-001835-0s7ok4uw	1094	15	cancer	cancer	NN
cord-001835-0s7ok4uw	1094	16	types	type	NNS
cord-001835-0s7ok4uw	1094	17	.	.	.
cord-001835-0s7ok4uw	1095	1	These	these	DT
cord-001835-0s7ok4uw	1095	2	functions	function	NNS
cord-001835-0s7ok4uw	1095	3	require	require	VBP
cord-001835-0s7ok4uw	1095	4	further	further	JJ
cord-001835-0s7ok4uw	1095	5	investigation	investigation	NN
cord-001835-0s7ok4uw	1095	6	to	to	TO
cord-001835-0s7ok4uw	1095	7	determine	determine	VB
cord-001835-0s7ok4uw	1095	8	the	the	DT
cord-001835-0s7ok4uw	1095	9	scope	scope	NN
cord-001835-0s7ok4uw	1095	10	of	of	IN
cord-001835-0s7ok4uw	1095	11	SGTA	SGTA	NNP
cord-001835-0s7ok4uw	1095	12	as	as	IN
cord-001835-0s7ok4uw	1095	13	a	a	DT
cord-001835-0s7ok4uw	1095	14	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	1095	15	target	target	NN
cord-001835-0s7ok4uw	1095	16	.	.	.
cord-001835-0s7ok4uw	1096	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1096	2	lab	lab	NN
cord-001835-0s7ok4uw	1096	3	has	have	VBZ
cord-001835-0s7ok4uw	1096	4	solved	solve	VBN
cord-001835-0s7ok4uw	1096	5	the	the	DT
cord-001835-0s7ok4uw	1096	6	solution	solution	NN
cord-001835-0s7ok4uw	1096	7	structure	structure	NN
cord-001835-0s7ok4uw	1096	8	of	of	IN
cord-001835-0s7ok4uw	1096	9	the	the	DT
cord-001835-0s7ok4uw	1096	10	N	n	CD
cord-001835-0s7ok4uw	1096	11	-	-	HYPH
cord-001835-0s7ok4uw	1096	12	terminal	terminal	JJ
cord-001835-0s7ok4uw	1096	13	dimerization	dimerization	NN
cord-001835-0s7ok4uw	1096	14	domain	domain	NN
cord-001835-0s7ok4uw	1096	15	of	of	IN
cord-001835-0s7ok4uw	1096	16	SGTA	SGTA	NNP
cord-001835-0s7ok4uw	1096	17	and	and	CC
cord-001835-0s7ok4uw	1096	18	characterised	characterise	VBD
cord-001835-0s7ok4uw	1096	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1096	20	interaction	interaction	NN
cord-001835-0s7ok4uw	1096	21	with	with	IN
cord-001835-0s7ok4uw	1096	22	two	two	CD
cord-001835-0s7ok4uw	1096	23	different	different	JJ
cord-001835-0s7ok4uw	1096	24	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	1096	25	-	-	HYPH
cord-001835-0s7ok4uw	1096	26	like	like	JJ
cord-001835-0s7ok4uw	1096	27	(	(	-LRB-
cord-001835-0s7ok4uw	1096	28	UBL	UBL	NNP
cord-001835-0s7ok4uw	1096	29	)	)	-RRB-
cord-001835-0s7ok4uw	1096	30	domains	domain	NNS
cord-001835-0s7ok4uw	1096	31	in	in	IN
cord-001835-0s7ok4uw	1096	32	the	the	DT
cord-001835-0s7ok4uw	1096	33	BAG6	BAG6	NNP
cord-001835-0s7ok4uw	1096	34	holdase	holdase	NNP
cord-001835-0s7ok4uw	1096	35	(	(	-LRB-
cord-001835-0s7ok4uw	1096	36	one	one	CD
cord-001835-0s7ok4uw	1096	37	from	from	IN
cord-001835-0s7ok4uw	1096	38	UBL4A	ubl4a	CD
cord-001835-0s7ok4uw	1096	39	and	and	CC
cord-001835-0s7ok4uw	1096	40	the	the	DT
cord-001835-0s7ok4uw	1096	41	other	other	JJ
cord-001835-0s7ok4uw	1096	42	from	from	IN
cord-001835-0s7ok4uw	1096	43	BAG6	BAG6	NNP
cord-001835-0s7ok4uw	1096	44	itself	-PRON-	PRP
cord-001835-0s7ok4uw	1096	45	)	)	-RRB-
cord-001835-0s7ok4uw	1096	46	using	use	VBG
cord-001835-0s7ok4uw	1096	47	NMR	NMR	NNP
cord-001835-0s7ok4uw	1096	48	chemical	chemical	JJ
cord-001835-0s7ok4uw	1096	49	shift	shift	NN
cord-001835-0s7ok4uw	1096	50	perturbation	perturbation	NN
cord-001835-0s7ok4uw	1096	51	data	datum	NNS
cord-001835-0s7ok4uw	1096	52	and	and	CC
cord-001835-0s7ok4uw	1096	53	other	other	JJ
cord-001835-0s7ok4uw	1096	54	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	1096	55	techniques	technique	NNS
cord-001835-0s7ok4uw	1096	56	including	include	VBG
cord-001835-0s7ok4uw	1096	57	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	1096	58	titration	titration	NN
cord-001835-0s7ok4uw	1096	59	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	1096	60	and	and	CC
cord-001835-0s7ok4uw	1096	61	microscale	microscale	JJ
cord-001835-0s7ok4uw	1096	62	thermophoresis	thermophoresis	NN
cord-001835-0s7ok4uw	1096	63	.	.	.
cord-001835-0s7ok4uw	1097	1	At	at	IN
cord-001835-0s7ok4uw	1097	2	this	this	DT
cord-001835-0s7ok4uw	1097	3	meeting	meeting	NN
cord-001835-0s7ok4uw	1097	4	I	-PRON-	PRP
cord-001835-0s7ok4uw	1097	5	will	will	MD
cord-001835-0s7ok4uw	1097	6	report	report	VB
cord-001835-0s7ok4uw	1097	7	on	on	IN
cord-001835-0s7ok4uw	1097	8	the	the	DT
cord-001835-0s7ok4uw	1097	9	progress	progress	NN
cord-001835-0s7ok4uw	1097	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	1097	11	have	have	VBP
cord-001835-0s7ok4uw	1097	12	made	make	VBN
cord-001835-0s7ok4uw	1097	13	in	in	IN
cord-001835-0s7ok4uw	1097	14	structurally	structurally	RB
cord-001835-0s7ok4uw	1097	15	characterising	characterise	VBG
cord-001835-0s7ok4uw	1097	16	further	further	JJ
cord-001835-0s7ok4uw	1097	17	key	key	JJ
cord-001835-0s7ok4uw	1097	18	players	player	NNS
cord-001835-0s7ok4uw	1097	19	that	that	WDT
cord-001835-0s7ok4uw	1097	20	participate	participate	VBP
cord-001835-0s7ok4uw	1097	21	in	in	IN
cord-001835-0s7ok4uw	1097	22	this	this	DT
cord-001835-0s7ok4uw	1097	23	quality	quality	NN
cord-001835-0s7ok4uw	1097	24	control	control	NN
cord-001835-0s7ok4uw	1097	25	,	,	,
cord-001835-0s7ok4uw	1097	26	with	with	IN
cord-001835-0s7ok4uw	1097	27	the	the	DT
cord-001835-0s7ok4uw	1097	28	aim	aim	NN
cord-001835-0s7ok4uw	1097	29	of	of	IN
cord-001835-0s7ok4uw	1097	30	clarifying	clarify	VBG
cord-001835-0s7ok4uw	1097	31	the	the	DT
cord-001835-0s7ok4uw	1097	32	intricate	intricate	JJ
cord-001835-0s7ok4uw	1097	33	network	network	NN
cord-001835-0s7ok4uw	1097	34	of	of	IN
cord-001835-0s7ok4uw	1097	35	molecular	molecular	JJ
cord-001835-0s7ok4uw	1097	36	interactions	interaction	NNS
cord-001835-0s7ok4uw	1097	37	that	that	WDT
cord-001835-0s7ok4uw	1097	38	governs	govern	VBZ
cord-001835-0s7ok4uw	1097	39	these	these	DT
cord-001835-0s7ok4uw	1097	40	processes	process	NNS
cord-001835-0s7ok4uw	1097	41	in	in	IN
cord-001835-0s7ok4uw	1097	42	health	health	NN
cord-001835-0s7ok4uw	1097	43	and	and	CC
cord-001835-0s7ok4uw	1097	44	disease	disease	NN
cord-001835-0s7ok4uw	1097	45	.	.	.
cord-001835-0s7ok4uw	1098	1	Ensemble	ensemble	NN
cord-001835-0s7ok4uw	1098	2	,	,	,
cord-001835-0s7ok4uw	1098	3	ribbon	ribbon	NN
cord-001835-0s7ok4uw	1098	4	and	and	CC
cord-001835-0s7ok4uw	1098	5	electrostatics	electrostatic	NNS
cord-001835-0s7ok4uw	1098	6	spacefill	spacefill	NNP
cord-001835-0s7ok4uw	1098	7	views	view	NNS
cord-001835-0s7ok4uw	1098	8	of	of	IN
cord-001835-0s7ok4uw	1098	9	the	the	DT
cord-001835-0s7ok4uw	1098	10	SGTA	SGTA	NNP
cord-001835-0s7ok4uw	1098	11	dimerization	dimerization	NN
cord-001835-0s7ok4uw	1098	12	domain	domain	NN
cord-001835-0s7ok4uw	1098	13	structure	structure	NN
cord-001835-0s7ok4uw	1098	14	.	.	.
cord-001835-0s7ok4uw	1099	1	The	the	DT
cord-001835-0s7ok4uw	1099	2	final	final	JJ
cord-001835-0s7ok4uw	1099	3	panel	panel	NN
cord-001835-0s7ok4uw	1099	4	shows	show	VBZ
cord-001835-0s7ok4uw	1099	5	the	the	DT
cord-001835-0s7ok4uw	1099	6	structure	structure	NN
cord-001835-0s7ok4uw	1099	7	overlaid	overlay	VBN
cord-001835-0s7ok4uw	1099	8	with	with	IN
cord-001835-0s7ok4uw	1099	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1099	10	yeast	yeast	NN
cord-001835-0s7ok4uw	1099	11	homologue	homologue	NN
cord-001835-0s7ok4uw	1099	12	.	.	.
cord-001835-0s7ok4uw	1099	13	 	 	_SP
cord-001835-0s7ok4uw	1100	1	Alpha	Alpha	NNP
cord-001835-0s7ok4uw	1100	2	synuclein	synuclein	NNP
cord-001835-0s7ok4uw	1100	3	is	be	VBZ
cord-001835-0s7ok4uw	1100	4	a	a	DT
cord-001835-0s7ok4uw	1100	5	small	small	JJ
cord-001835-0s7ok4uw	1100	6	protein	protein	NN
cord-001835-0s7ok4uw	1100	7	(	(	-LRB-
cord-001835-0s7ok4uw	1100	8	14	14	CD
cord-001835-0s7ok4uw	1100	9	kDa	kDa	NNS
cord-001835-0s7ok4uw	1100	10	)	)	-RRB-
cord-001835-0s7ok4uw	1100	11	expressed	express	VBD
cord-001835-0s7ok4uw	1100	12	at	at	IN
cord-001835-0s7ok4uw	1100	13	high	high	JJ
cord-001835-0s7ok4uw	1100	14	levels	level	NNS
cord-001835-0s7ok4uw	1100	15	in	in	IN
cord-001835-0s7ok4uw	1100	16	dopaminergic	dopaminergic	JJ
cord-001835-0s7ok4uw	1100	17	neurons	neuron	NNS
cord-001835-0s7ok4uw	1100	18	.	.	.
cord-001835-0s7ok4uw	1101	1	Fibrillar	Fibrillar	NNP
cord-001835-0s7ok4uw	1101	2	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	1101	3	of	of	IN
cord-001835-0s7ok4uw	1101	4	a	a	DT
cord-001835-0s7ok4uw	1101	5	-	-	HYPH
cord-001835-0s7ok4uw	1101	6	synuclein	synuclein	NN
cord-001835-0s7ok4uw	1101	7	inside	inside	IN
cord-001835-0s7ok4uw	1101	8	the	the	DT
cord-001835-0s7ok4uw	1101	9	dopaminergic	dopaminergic	JJ
cord-001835-0s7ok4uw	1101	10	neuron	neuron	NN
cord-001835-0s7ok4uw	1101	11	are	be	VBP
cord-001835-0s7ok4uw	1101	12	the	the	DT
cord-001835-0s7ok4uw	1101	13	major	major	JJ
cord-001835-0s7ok4uw	1101	14	components	component	NNS
cord-001835-0s7ok4uw	1101	15	of	of	IN
cord-001835-0s7ok4uw	1101	16	Lewy	Lewy	NNP
cord-001835-0s7ok4uw	1101	17	bodies	body	NNS
cord-001835-0s7ok4uw	1101	18	and	and	CC
cord-001835-0s7ok4uw	1101	19	Lewy	Lewy	NNP
cord-001835-0s7ok4uw	1101	20	neuritis	neuritis	NN
cord-001835-0s7ok4uw	1101	21	inclusion	inclusion	NN
cord-001835-0s7ok4uw	1101	22	,	,	,
cord-001835-0s7ok4uw	1101	23	which	which	WDT
cord-001835-0s7ok4uw	1101	24	are	be	VBP
cord-001835-0s7ok4uw	1101	25	considered	consider	VBN
cord-001835-0s7ok4uw	1101	26	as	as	IN
cord-001835-0s7ok4uw	1101	27	potential	potential	JJ
cord-001835-0s7ok4uw	1101	28	hallmark	hallmark	NN
cord-001835-0s7ok4uw	1101	29	of	of	IN
cord-001835-0s7ok4uw	1101	30	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	1101	31	's	's	POS
cord-001835-0s7ok4uw	1101	32	disease	disease	NN
cord-001835-0s7ok4uw	1101	33	(	(	-LRB-
cord-001835-0s7ok4uw	1101	34	PD	PD	NNP
cord-001835-0s7ok4uw	1101	35	)	)	-RRB-
cord-001835-0s7ok4uw	1101	36	.	.	.
cord-001835-0s7ok4uw	1102	1	Both	both	DT
cord-001835-0s7ok4uw	1102	2	in	in	IN
cord-001835-0s7ok4uw	1102	3	vitro	vitro	FW
cord-001835-0s7ok4uw	1102	4	as	as	RB
cord-001835-0s7ok4uw	1102	5	well	well	RB
cord-001835-0s7ok4uw	1102	6	as	as	IN
cord-001835-0s7ok4uw	1102	7	in	in	IN
cord-001835-0s7ok4uw	1102	8	vivo	vivo	NNP
cord-001835-0s7ok4uw	1102	9	studies	study	NNS
cord-001835-0s7ok4uw	1102	10	suggest	suggest	VBP
cord-001835-0s7ok4uw	1102	11	that	that	IN
cord-001835-0s7ok4uw	1102	12	the	the	DT
cord-001835-0s7ok4uw	1102	13	soluble	soluble	JJ
cord-001835-0s7ok4uw	1102	14	,	,	,
cord-001835-0s7ok4uw	1102	15	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	1102	16	forms	form	NNS
cord-001835-0s7ok4uw	1102	17	of	of	IN
cord-001835-0s7ok4uw	1102	18	a	a	DT
cord-001835-0s7ok4uw	1102	19	-	-	HYPH
cord-001835-0s7ok4uw	1102	20	Syn	Syn	NNP
cord-001835-0s7ok4uw	1102	21	are	be	VBP
cord-001835-0s7ok4uw	1102	22	the	the	DT
cord-001835-0s7ok4uw	1102	23	more	more	RBR
cord-001835-0s7ok4uw	1102	24	potent	potent	JJ
cord-001835-0s7ok4uw	1102	25	neurotoxic	neurotoxic	JJ
cord-001835-0s7ok4uw	1102	26	species	specie	NNS
cord-001835-0s7ok4uw	1102	27	,	,	,
cord-001835-0s7ok4uw	1102	28	responsible	responsible	JJ
cord-001835-0s7ok4uw	1102	29	for	for	IN
cord-001835-0s7ok4uw	1102	30	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	1102	31	injury	injury	NN
cord-001835-0s7ok4uw	1102	32	and	and	CC
cord-001835-0s7ok4uw	1102	33	death	death	NN
cord-001835-0s7ok4uw	1102	34	in	in	IN
cord-001835-0s7ok4uw	1102	35	PD	PD	NNP
cord-001835-0s7ok4uw	1102	36	.	.	.
cord-001835-0s7ok4uw	1103	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	1103	2	,	,	,
cord-001835-0s7ok4uw	1103	3	molecules	molecule	NNS
cord-001835-0s7ok4uw	1103	4	that	that	WDT
cord-001835-0s7ok4uw	1103	5	inhibit	inhibit	VBP
cord-001835-0s7ok4uw	1103	6	the	the	DT
cord-001835-0s7ok4uw	1103	7	toxicity	toxicity	NN
cord-001835-0s7ok4uw	1103	8	of	of	IN
cord-001835-0s7ok4uw	1103	9	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	1103	10	either	either	CC
cord-001835-0s7ok4uw	1103	11	by	by	IN
cord-001835-0s7ok4uw	1103	12	reducing	reduce	VBG
cord-001835-0s7ok4uw	1103	13	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1103	14	formation	formation	NN
cord-001835-0s7ok4uw	1103	15	or	or	CC
cord-001835-0s7ok4uw	1103	16	by	by	IN
cord-001835-0s7ok4uw	1103	17	converting	convert	VBG
cord-001835-0s7ok4uw	1103	18	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1103	19	more	more	RBR
cord-001835-0s7ok4uw	1103	20	toxic	toxic	JJ
cord-001835-0s7ok4uw	1103	21	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	1103	22	state	state	NN
cord-001835-0s7ok4uw	1103	23	to	to	IN
cord-001835-0s7ok4uw	1103	24	less	less	RBR
cord-001835-0s7ok4uw	1103	25	-	-	HYPH
cord-001835-0s7ok4uw	1103	26	toxic	toxic	JJ
cord-001835-0s7ok4uw	1103	27	fibrillar	fibrillar	JJ
cord-001835-0s7ok4uw	1103	28	state	state	NN
cord-001835-0s7ok4uw	1103	29	would	would	MD
cord-001835-0s7ok4uw	1103	30	be	be	VB
cord-001835-0s7ok4uw	1103	31	effective	effective	JJ
cord-001835-0s7ok4uw	1103	32	agents	agent	NNS
cord-001835-0s7ok4uw	1103	33	for	for	IN
cord-001835-0s7ok4uw	1103	34	the	the	DT
cord-001835-0s7ok4uw	1103	35	drug	drug	NN
cord-001835-0s7ok4uw	1103	36	development	development	NN
cord-001835-0s7ok4uw	1103	37	against	against	IN
cord-001835-0s7ok4uw	1103	38	PD	PD	NNP
cord-001835-0s7ok4uw	1103	39	.	.	.
cord-001835-0s7ok4uw	1104	1	Curcumin	curcumin	NN
cord-001835-0s7ok4uw	1104	2	is	be	VBZ
cord-001835-0s7ok4uw	1104	3	one	one	CD
cord-001835-0s7ok4uw	1104	4	of	of	IN
cord-001835-0s7ok4uw	1104	5	the	the	DT
cord-001835-0s7ok4uw	1104	6	Asian	asian	JJ
cord-001835-0s7ok4uw	1104	7	food	food	NN
cord-001835-0s7ok4uw	1104	8	ingredients	ingredient	NNS
cord-001835-0s7ok4uw	1104	9	which	which	WDT
cord-001835-0s7ok4uw	1104	10	has	have	VBZ
cord-001835-0s7ok4uw	1104	11	shown	show	VBN
cord-001835-0s7ok4uw	1104	12	a	a	DT
cord-001835-0s7ok4uw	1104	13	potential	potential	JJ
cord-001835-0s7ok4uw	1104	14	role	role	NN
cord-001835-0s7ok4uw	1104	15	as	as	IN
cord-001835-0s7ok4uw	1104	16	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	1104	17	agent	agent	NN
cord-001835-0s7ok4uw	1104	18	against	against	IN
cord-001835-0s7ok4uw	1104	19	many	many	JJ
cord-001835-0s7ok4uw	1104	20	neurological	neurological	JJ
cord-001835-0s7ok4uw	1104	21	disorders	disorder	NNS
cord-001835-0s7ok4uw	1104	22	including	include	VBG
cord-001835-0s7ok4uw	1104	23	PD	PD	NNP
cord-001835-0s7ok4uw	1104	24	.	.	.
cord-001835-0s7ok4uw	1105	1	However	however	RB
cord-001835-0s7ok4uw	1105	2	,	,	,
cord-001835-0s7ok4uw	1105	3	the	the	DT
cord-001835-0s7ok4uw	1105	4	instability	instability	NN
cord-001835-0s7ok4uw	1105	5	and	and	CC
cord-001835-0s7ok4uw	1105	6	low	low	JJ
cord-001835-0s7ok4uw	1105	7	solubility	solubility	NN
cord-001835-0s7ok4uw	1105	8	makes	make	VBZ
cord-001835-0s7ok4uw	1105	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	1105	10	less	less	RBR
cord-001835-0s7ok4uw	1105	11	attractive	attractive	JJ
cord-001835-0s7ok4uw	1105	12	for	for	IN
cord-001835-0s7ok4uw	1105	13	use	use	NN
cord-001835-0s7ok4uw	1105	14	as	as	IN
cord-001835-0s7ok4uw	1105	15	potential	potential	JJ
cord-001835-0s7ok4uw	1105	16	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	1105	17	agent	agent	NN
cord-001835-0s7ok4uw	1105	18	.	.	.
cord-001835-0s7ok4uw	1106	1	The	the	DT
cord-001835-0s7ok4uw	1106	2	present	present	JJ
cord-001835-0s7ok4uw	1106	3	work	work	NN
cord-001835-0s7ok4uw	1106	4	focuses	focus	VBZ
cord-001835-0s7ok4uw	1106	5	on	on	IN
cord-001835-0s7ok4uw	1106	6	screening	screening	NN
cord-001835-0s7ok4uw	1106	7	of	of	IN
cord-001835-0s7ok4uw	1106	8	the	the	DT
cord-001835-0s7ok4uw	1106	9	compounds	compound	NNS
cord-001835-0s7ok4uw	1106	10	similar	similar	JJ
cord-001835-0s7ok4uw	1106	11	to	to	IN
cord-001835-0s7ok4uw	1106	12	curcumin	curcumin	NN
cord-001835-0s7ok4uw	1106	13	but	but	CC
cord-001835-0s7ok4uw	1106	14	having	have	VBG
cord-001835-0s7ok4uw	1106	15	better	well	JJR
cord-001835-0s7ok4uw	1106	16	effects	effect	NNS
cord-001835-0s7ok4uw	1106	17	on	on	IN
cord-001835-0s7ok4uw	1106	18	the	the	DT
cord-001835-0s7ok4uw	1106	19	morphology	morphology	NN
cord-001835-0s7ok4uw	1106	20	and	and	CC
cord-001835-0s7ok4uw	1106	21	toxicity	toxicity	NN
cord-001835-0s7ok4uw	1106	22	of	of	IN
cord-001835-0s7ok4uw	1106	23	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	1106	24	and	and	CC
cord-001835-0s7ok4uw	1106	25	fibrillar	fibrillar	NNP
cord-001835-0s7ok4uw	1106	26	assemblies	assembly	NNS
cord-001835-0s7ok4uw	1106	27	of	of	IN
cord-001835-0s7ok4uw	1106	28	a	a	DT
cord-001835-0s7ok4uw	1106	29	-	-	HYPH
cord-001835-0s7ok4uw	1106	30	Syn	Syn	NNP
cord-001835-0s7ok4uw	1106	31	,	,	,
cord-001835-0s7ok4uw	1106	32	which	which	WDT
cord-001835-0s7ok4uw	1106	33	could	could	MD
cord-001835-0s7ok4uw	1106	34	be	be	VB
cord-001835-0s7ok4uw	1106	35	used	use	VBN
cord-001835-0s7ok4uw	1106	36	as	as	IN
cord-001835-0s7ok4uw	1106	37	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	1106	38	agent	agent	NN
cord-001835-0s7ok4uw	1106	39	preferentially	preferentially	RB
cord-001835-0s7ok4uw	1106	40	over	over	IN
cord-001835-0s7ok4uw	1106	41	the	the	DT
cord-001835-0s7ok4uw	1106	42	naturally	naturally	RB
cord-001835-0s7ok4uw	1106	43	occurring	occur	VBG
cord-001835-0s7ok4uw	1106	44	curcumin	curcumin	NN
cord-001835-0s7ok4uw	1106	45	.	.	.
cord-001835-0s7ok4uw	1107	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1107	2	synthesized	synthesize	VBD
cord-001835-0s7ok4uw	1107	3	and	and	CC
cord-001835-0s7ok4uw	1107	4	analyzed	analyze	VBD
cord-001835-0s7ok4uw	1107	5	the	the	DT
cord-001835-0s7ok4uw	1107	6	effects	effect	NNS
cord-001835-0s7ok4uw	1107	7	of	of	IN
cord-001835-0s7ok4uw	1107	8	nine	nine	CD
cord-001835-0s7ok4uw	1107	9	compounds	compound	NNS
cord-001835-0s7ok4uw	1107	10	,	,	,
cord-001835-0s7ok4uw	1107	11	which	which	WDT
cord-001835-0s7ok4uw	1107	12	are	be	VBP
cord-001835-0s7ok4uw	1107	13	structurally	structurally	RB
cord-001835-0s7ok4uw	1107	14	similar	similar	JJ
cord-001835-0s7ok4uw	1107	15	to	to	IN
cord-001835-0s7ok4uw	1107	16	curcumin	curcumin	NN
cord-001835-0s7ok4uw	1107	17	,	,	,
cord-001835-0s7ok4uw	1107	18	on	on	IN
cord-001835-0s7ok4uw	1107	19	different	different	JJ
cord-001835-0s7ok4uw	1107	20	stages	stage	NNS
cord-001835-0s7ok4uw	1107	21	of	of	IN
cord-001835-0s7ok4uw	1107	22	a	a	DT
cord-001835-0s7ok4uw	1107	23	-	-	HYPH
cord-001835-0s7ok4uw	1107	24	Syn	syn	JJ
cord-001835-0s7ok4uw	1107	25	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1107	26	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1107	27	.	.	.
cord-001835-0s7ok4uw	1108	1	Here	here	RB
cord-001835-0s7ok4uw	1108	2	,	,	,
cord-001835-0s7ok4uw	1108	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1108	4	showed	show	VBD
cord-001835-0s7ok4uw	1108	5	that	that	IN
cord-001835-0s7ok4uw	1108	6	curcumin	curcumin	NN
cord-001835-0s7ok4uw	1108	7	and	and	CC
cord-001835-0s7ok4uw	1108	8	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1108	9	analogs	analog	NNS
cord-001835-0s7ok4uw	1108	10	accelerate	accelerate	VBP
cord-001835-0s7ok4uw	1108	11	a	a	DT
cord-001835-0s7ok4uw	1108	12	-	-	HYPH
cord-001835-0s7ok4uw	1108	13	Syn	syn	NN
cord-001835-0s7ok4uw	1108	14	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1108	15	to	to	TO
cord-001835-0s7ok4uw	1108	16	produce	produce	VB
cord-001835-0s7ok4uw	1108	17	morphologically	morphologically	RB
cord-001835-0s7ok4uw	1108	18	different	different	JJ
cord-001835-0s7ok4uw	1108	19	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1108	20	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1108	21	in	in	IN
cord-001835-0s7ok4uw	1108	22	vitro	vitro	FW
cord-001835-0s7ok4uw	1108	23	.	.	.
cord-001835-0s7ok4uw	1109	1	However	however	RB
cord-001835-0s7ok4uw	1109	2	,	,	,
cord-001835-0s7ok4uw	1109	3	there	there	EX
cord-001835-0s7ok4uw	1109	4	is	be	VBZ
cord-001835-0s7ok4uw	1109	5	no	no	DT
cord-001835-0s7ok4uw	1109	6	significant	significant	JJ
cord-001835-0s7ok4uw	1109	7	effect	effect	NN
cord-001835-0s7ok4uw	1109	8	of	of	IN
cord-001835-0s7ok4uw	1109	9	curcumin	curcumin	NN
cord-001835-0s7ok4uw	1109	10	and	and	CC
cord-001835-0s7ok4uw	1109	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1109	12	analogs	analog	NNS
cord-001835-0s7ok4uw	1109	13	on	on	IN
cord-001835-0s7ok4uw	1109	14	the	the	DT
cord-001835-0s7ok4uw	1109	15	secondary	secondary	JJ
cord-001835-0s7ok4uw	1109	16	structure	structure	NN
cord-001835-0s7ok4uw	1109	17	of	of	IN
cord-001835-0s7ok4uw	1109	18	preformed	preformed	JJ
cord-001835-0s7ok4uw	1109	19	a	a	DT
cord-001835-0s7ok4uw	1109	20	-	-	HYPH
cord-001835-0s7ok4uw	1109	21	Syn	syn	NN
cord-001835-0s7ok4uw	1109	22	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1109	23	.	.	.
cord-001835-0s7ok4uw	1110	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1110	2	,	,	,
cord-001835-0s7ok4uw	1110	3	these	these	DT
cord-001835-0s7ok4uw	1110	4	curcumin	curcumin	NN
cord-001835-0s7ok4uw	1110	5	analogs	analog	NNS
cord-001835-0s7ok4uw	1110	6	showed	show	VBD
cord-001835-0s7ok4uw	1110	7	differential	differential	JJ
cord-001835-0s7ok4uw	1110	8	binding	bind	VBG
cord-001835-0s7ok4uw	1110	9	affinities	affinity	NNS
cord-001835-0s7ok4uw	1110	10	with	with	IN
cord-001835-0s7ok4uw	1110	11	the	the	DT
cord-001835-0s7ok4uw	1110	12	preformed	preformed	JJ
cord-001835-0s7ok4uw	1110	13	a	a	DT
cord-001835-0s7ok4uw	1110	14	-	-	HYPH
cord-001835-0s7ok4uw	1110	15	Syn	syn	NN
cord-001835-0s7ok4uw	1110	16	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	1110	17	,	,	,
cord-001835-0s7ok4uw	1110	18	possibly	possibly	RB
cord-001835-0s7ok4uw	1110	19	due	due	JJ
cord-001835-0s7ok4uw	1110	20	to	to	IN
cord-001835-0s7ok4uw	1110	21	difference	difference	NN
cord-001835-0s7ok4uw	1110	22	in	in	IN
cord-001835-0s7ok4uw	1110	23	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1110	24	chemical	chemical	JJ
cord-001835-0s7ok4uw	1110	25	structures	structure	NNS
cord-001835-0s7ok4uw	1110	26	.	.	.
cord-001835-0s7ok4uw	1111	1	The	the	DT
cord-001835-0s7ok4uw	1111	2	present	present	JJ
cord-001835-0s7ok4uw	1111	3	data	datum	NNS
cord-001835-0s7ok4uw	1111	4	suggest	suggest	VBP
cord-001835-0s7ok4uw	1111	5	the	the	DT
cord-001835-0s7ok4uw	1111	6	promising	promising	JJ
cord-001835-0s7ok4uw	1111	7	role	role	NN
cord-001835-0s7ok4uw	1111	8	of	of	IN
cord-001835-0s7ok4uw	1111	9	curcumin	curcumin	NN
cord-001835-0s7ok4uw	1111	10	analogs	analog	NNS
cord-001835-0s7ok4uw	1111	11	in	in	IN
cord-001835-0s7ok4uw	1111	12	the	the	DT
cord-001835-0s7ok4uw	1111	13	treatment	treatment	NN
cord-001835-0s7ok4uw	1111	14	of	of	IN
cord-001835-0s7ok4uw	1111	15	a	a	DT
cord-001835-0s7ok4uw	1111	16	-	-	HYPH
cord-001835-0s7ok4uw	1111	17	synucleinopathy	synucleinopathy	NN
cord-001835-0s7ok4uw	1111	18	disorders	disorder	NNS
cord-001835-0s7ok4uw	1111	19	.	.	.
cord-001835-0s7ok4uw	1112	1	In	in	IN
cord-001835-0s7ok4uw	1112	2	vitro	vitro	FW
cord-001835-0s7ok4uw	1112	3	folding	folding	NN
cord-001835-0s7ok4uw	1112	4	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1112	5	determine	determine	VBP
cord-001835-0s7ok4uw	1112	6	the	the	DT
cord-001835-0s7ok4uw	1112	7	forces	force	NNS
cord-001835-0s7ok4uw	1112	8	applied	apply	VBN
cord-001835-0s7ok4uw	1112	9	during	during	IN
cord-001835-0s7ok4uw	1112	10	co	co	JJ
cord-001835-0s7ok4uw	1112	11	-	-	JJ
cord-001835-0s7ok4uw	1112	12	translational	translational	JJ
cord-001835-0s7ok4uw	1112	13	folding	folding	NN
cord-001835-0s7ok4uw	1112	14	There	there	EX
cord-001835-0s7ok4uw	1112	15	is	be	VBZ
cord-001835-0s7ok4uw	1112	16	currently	currently	RB
cord-001835-0s7ok4uw	1112	17	much	much	JJ
cord-001835-0s7ok4uw	1112	18	debate	debate	NN
cord-001835-0s7ok4uw	1112	19	as	as	IN
cord-001835-0s7ok4uw	1112	20	to	to	IN
cord-001835-0s7ok4uw	1112	21	whether	whether	IN
cord-001835-0s7ok4uw	1112	22	experiments	experiment	NNS
cord-001835-0s7ok4uw	1112	23	conducted	conduct	VBN
cord-001835-0s7ok4uw	1112	24	in	in	IN
cord-001835-0s7ok4uw	1112	25	vitro	vitro	FW
cord-001835-0s7ok4uw	1112	26	describe	describe	VBP
cord-001835-0s7ok4uw	1112	27	the	the	DT
cord-001835-0s7ok4uw	1112	28	folding	folding	NN
cord-001835-0s7ok4uw	1112	29	of	of	IN
cord-001835-0s7ok4uw	1112	30	proteins	protein	NNS
cord-001835-0s7ok4uw	1112	31	in	in	IN
cord-001835-0s7ok4uw	1112	32	vivo	vivo	NN
cord-001835-0s7ok4uw	1112	33	.	.	.
cord-001835-0s7ok4uw	1113	1	In	in	IN
cord-001835-0s7ok4uw	1113	2	particular	particular	JJ
cord-001835-0s7ok4uw	1113	3	,	,	,
cord-001835-0s7ok4uw	1113	4	it	-PRON-	PRP
cord-001835-0s7ok4uw	1113	5	is	be	VBZ
cord-001835-0s7ok4uw	1113	6	often	often	RB
cord-001835-0s7ok4uw	1113	7	suggested	suggest	VBN
cord-001835-0s7ok4uw	1113	8	that	that	IN
cord-001835-0s7ok4uw	1113	9	the	the	DT
cord-001835-0s7ok4uw	1113	10	co	co	JJ
cord-001835-0s7ok4uw	1113	11	-	-	JJ
cord-001835-0s7ok4uw	1113	12	translational	translational	JJ
cord-001835-0s7ok4uw	1113	13	folding	folding	NN
cord-001835-0s7ok4uw	1113	14	of	of	IN
cord-001835-0s7ok4uw	1113	15	nascent	nascent	JJ
cord-001835-0s7ok4uw	1113	16	protein	protein	NN
cord-001835-0s7ok4uw	1113	17	chains	chain	NNS
cord-001835-0s7ok4uw	1113	18	is	be	VBZ
cord-001835-0s7ok4uw	1113	19	dominated	dominate	VBN
cord-001835-0s7ok4uw	1113	20	by	by	IN
cord-001835-0s7ok4uw	1113	21	the	the	DT
cord-001835-0s7ok4uw	1113	22	presence	presence	NN
cord-001835-0s7ok4uw	1113	23	of	of	IN
cord-001835-0s7ok4uw	1113	24	the	the	DT
cord-001835-0s7ok4uw	1113	25	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1113	26	and	and	CC
cord-001835-0s7ok4uw	1113	27	associated	associated	JJ
cord-001835-0s7ok4uw	1113	28	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	1113	29	,	,	,
cord-001835-0s7ok4uw	1113	30	and	and	CC
cord-001835-0s7ok4uw	1113	31	that	that	IN
cord-001835-0s7ok4uw	1113	32	folding	folding	NN
cord-001835-0s7ok4uw	1113	33	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1113	34	will	will	MD
cord-001835-0s7ok4uw	1113	35	be	be	VB
cord-001835-0s7ok4uw	1113	36	affected	affect	VBN
cord-001835-0s7ok4uw	1113	37	by	by	IN
cord-001835-0s7ok4uw	1113	38	the	the	DT
cord-001835-0s7ok4uw	1113	39	vectorial	vectorial	JJ
cord-001835-0s7ok4uw	1113	40	nature	nature	NN
cord-001835-0s7ok4uw	1113	41	of	of	IN
cord-001835-0s7ok4uw	1113	42	translation	translation	NN
cord-001835-0s7ok4uw	1113	43	.	.	.
cord-001835-0s7ok4uw	1114	1	Here	here	RB
cord-001835-0s7ok4uw	1114	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	1114	3	use	use	VBP
cord-001835-0s7ok4uw	1114	4	an	an	DT
cord-001835-0s7ok4uw	1114	5	arrest	arrest	NN
cord-001835-0s7ok4uw	1114	6	peptide	peptide	NN
cord-001835-0s7ok4uw	1114	7	assay	assay	NN
cord-001835-0s7ok4uw	1114	8	to	to	TO
cord-001835-0s7ok4uw	1114	9	investigate	investigate	VB
cord-001835-0s7ok4uw	1114	10	the	the	DT
cord-001835-0s7ok4uw	1114	11	co	co	JJ
cord-001835-0s7ok4uw	1114	12	-	-	JJ
cord-001835-0s7ok4uw	1114	13	translational	translational	JJ
cord-001835-0s7ok4uw	1114	14	folding	folding	NN
cord-001835-0s7ok4uw	1114	15	of	of	IN
cord-001835-0s7ok4uw	1114	16	a	a	DT
cord-001835-0s7ok4uw	1114	17	number	number	NN
cord-001835-0s7ok4uw	1114	18	of	of	IN
cord-001835-0s7ok4uw	1114	19	all	all	DT
cord-001835-0s7ok4uw	1114	20	-	-	HYPH
cord-001835-0s7ok4uw	1114	21	a	a	DT
cord-001835-0s7ok4uw	1114	22	spectrin	spectrin	NN
cord-001835-0s7ok4uw	1114	23	domains	domain	NNS
cord-001835-0s7ok4uw	1114	24	that	that	WDT
cord-001835-0s7ok4uw	1114	25	exhibit	exhibit	VBP
cord-001835-0s7ok4uw	1114	26	a	a	DT
cord-001835-0s7ok4uw	1114	27	range	range	NN
cord-001835-0s7ok4uw	1114	28	of	of	IN
cord-001835-0s7ok4uw	1114	29	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1114	30	stabilities	stability	NNS
cord-001835-0s7ok4uw	1114	31	and	and	CC
cord-001835-0s7ok4uw	1114	32	in	in	IN
cord-001835-0s7ok4uw	1114	33	vitro	vitro	FW
cord-001835-0s7ok4uw	1114	34	folding	folding	NN
cord-001835-0s7ok4uw	1114	35	rates	rate	NNS
cord-001835-0s7ok4uw	1114	36	.	.	.
cord-001835-0s7ok4uw	1115	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1115	2	unexpected	unexpected	JJ
cord-001835-0s7ok4uw	1115	3	finding	finding	NN
cord-001835-0s7ok4uw	1115	4	is	be	VBZ
cord-001835-0s7ok4uw	1115	5	that	that	IN
cord-001835-0s7ok4uw	1115	6	that	that	IN
cord-001835-0s7ok4uw	1115	7	the	the	DT
cord-001835-0s7ok4uw	1115	8	force	force	NN
cord-001835-0s7ok4uw	1115	9	exerted	exert	VBD
cord-001835-0s7ok4uw	1115	10	on	on	IN
cord-001835-0s7ok4uw	1115	11	the	the	DT
cord-001835-0s7ok4uw	1115	12	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1115	13	by	by	IN
cord-001835-0s7ok4uw	1115	14	these	these	DT
cord-001835-0s7ok4uw	1115	15	domains	domain	NNS
cord-001835-0s7ok4uw	1115	16	is	be	VBZ
cord-001835-0s7ok4uw	1115	17	not	not	RB
cord-001835-0s7ok4uw	1115	18	related	relate	VBN
cord-001835-0s7ok4uw	1115	19	to	to	IN
cord-001835-0s7ok4uw	1115	20	either	either	CC
cord-001835-0s7ok4uw	1115	21	the	the	DT
cord-001835-0s7ok4uw	1115	22	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1115	23	stability	stability	NN
cord-001835-0s7ok4uw	1115	24	of	of	IN
cord-001835-0s7ok4uw	1115	25	the	the	DT
cord-001835-0s7ok4uw	1115	26	domain	domain	NN
cord-001835-0s7ok4uw	1115	27	,	,	,
cord-001835-0s7ok4uw	1115	28	or	or	CC
cord-001835-0s7ok4uw	1115	29	to	to	IN
cord-001835-0s7ok4uw	1115	30	the	the	DT
cord-001835-0s7ok4uw	1115	31	folding	folding	NN
cord-001835-0s7ok4uw	1115	32	(	(	-LRB-
cord-001835-0s7ok4uw	1115	33	loading	load	VBG
cord-001835-0s7ok4uw	1115	34	)	)	-RRB-
cord-001835-0s7ok4uw	1115	35	rate	rate	NN
cord-001835-0s7ok4uw	1115	36	,	,	,
cord-001835-0s7ok4uw	1115	37	but	but	CC
cord-001835-0s7ok4uw	1115	38	rather	rather	RB
cord-001835-0s7ok4uw	1115	39	to	to	IN
cord-001835-0s7ok4uw	1115	40	the	the	DT
cord-001835-0s7ok4uw	1115	41	in	in	FW
cord-001835-0s7ok4uw	1115	42	vitro	vitro	FW
cord-001835-0s7ok4uw	1115	43	folding	folding	NN
cord-001835-0s7ok4uw	1115	44	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1115	45	.	.	.
cord-001835-0s7ok4uw	1116	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1116	2	infer	infer	VBP
cord-001835-0s7ok4uw	1116	3	that	that	IN
cord-001835-0s7ok4uw	1116	4	the	the	DT
cord-001835-0s7ok4uw	1116	5	in	in	FW
cord-001835-0s7ok4uw	1116	6	vitro	vitro	FW
cord-001835-0s7ok4uw	1116	7	folding	folding	NN
cord-001835-0s7ok4uw	1116	8	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1116	9	of	of	IN
cord-001835-0s7ok4uw	1116	10	these	these	DT
cord-001835-0s7ok4uw	1116	11	domains	domain	NNS
cord-001835-0s7ok4uw	1116	12	are	be	VBP
cord-001835-0s7ok4uw	1116	13	unaffected	unaffected	JJ
cord-001835-0s7ok4uw	1116	14	by	by	IN
cord-001835-0s7ok4uw	1116	15	the	the	DT
cord-001835-0s7ok4uw	1116	16	presence	presence	NN
cord-001835-0s7ok4uw	1116	17	of	of	IN
cord-001835-0s7ok4uw	1116	18	the	the	DT
cord-001835-0s7ok4uw	1116	19	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1116	20	-even	-even	VBN
cord-001835-0s7ok4uw	1117	1	when	when	WRB
cord-001835-0s7ok4uw	1117	2	part	part	NN
cord-001835-0s7ok4uw	1117	3	of	of	IN
cord-001835-0s7ok4uw	1117	4	the	the	DT
cord-001835-0s7ok4uw	1117	5	nascent	nascent	JJ
cord-001835-0s7ok4uw	1117	6	chain	chain	NN
cord-001835-0s7ok4uw	1117	7	is	be	VBZ
cord-001835-0s7ok4uw	1117	8	retained	retain	VBN
cord-001835-0s7ok4uw	1117	9	within	within	IN
cord-001835-0s7ok4uw	1117	10	the	the	DT
cord-001835-0s7ok4uw	1117	11	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1117	12	exit	exit	NN
cord-001835-0s7ok4uw	1117	13	tunnel	tunnel	NN
cord-001835-0s7ok4uw	1117	14	.	.	.
cord-001835-0s7ok4uw	1118	1	There	there	EX
cord-001835-0s7ok4uw	1118	2	has	have	VBZ
cord-001835-0s7ok4uw	1118	3	been	be	VBN
cord-001835-0s7ok4uw	1118	4	much	much	JJ
cord-001835-0s7ok4uw	1118	5	work	work	NN
cord-001835-0s7ok4uw	1118	6	to	to	IN
cord-001835-0s7ok4uw	1118	7	date	date	NN
cord-001835-0s7ok4uw	1118	8	investigating	investigate	VBG
cord-001835-0s7ok4uw	1118	9	the	the	DT
cord-001835-0s7ok4uw	1118	10	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	1118	11	present	present	JJ
cord-001835-0s7ok4uw	1118	12	in	in	IN
cord-001835-0s7ok4uw	1118	13	stalled	stall	VBN
cord-001835-0s7ok4uw	1118	14	translation	translation	NN
cord-001835-0s7ok4uw	1118	15	complexes	complex	NNS
cord-001835-0s7ok4uw	1118	16	-but	-but	:
cord-001835-0s7ok4uw	1118	17	now	now	RB
cord-001835-0s7ok4uw	1118	18	,	,	,
cord-001835-0s7ok4uw	1118	19	for	for	IN
cord-001835-0s7ok4uw	1118	20	the	the	DT
cord-001835-0s7ok4uw	1118	21	first	first	JJ
cord-001835-0s7ok4uw	1118	22	time	time	NN
cord-001835-0s7ok4uw	1118	23	,	,	,
cord-001835-0s7ok4uw	1118	24	we	-PRON-	PRP
cord-001835-0s7ok4uw	1118	25	can	can	MD
cord-001835-0s7ok4uw	1118	26	begin	begin	VB
cord-001835-0s7ok4uw	1118	27	to	to	TO
cord-001835-0s7ok4uw	1118	28	directly	directly	RB
cord-001835-0s7ok4uw	1118	29	explore	explore	VB
cord-001835-0s7ok4uw	1118	30	the	the	DT
cord-001835-0s7ok4uw	1118	31	rate	rate	NN
cord-001835-0s7ok4uw	1118	32	limiting	limit	VBG
cord-001835-0s7ok4uw	1118	33	transition	transition	NN
cord-001835-0s7ok4uw	1118	34	state	state	NN
cord-001835-0s7ok4uw	1118	35	in	in	IN
cord-001835-0s7ok4uw	1118	36	the	the	DT
cord-001835-0s7ok4uw	1118	37	co	co	JJ
cord-001835-0s7ok4uw	1118	38	-	-	JJ
cord-001835-0s7ok4uw	1118	39	translational	translational	JJ
cord-001835-0s7ok4uw	1118	40	folding	folding	NN
cord-001835-0s7ok4uw	1118	41	of	of	IN
cord-001835-0s7ok4uw	1118	42	homologous	homologous	JJ
cord-001835-0s7ok4uw	1118	43	proteins	protein	NNS
cord-001835-0s7ok4uw	1118	44	.	.	.
cord-001835-0s7ok4uw	1119	1	Can	Can	MD
cord-001835-0s7ok4uw	1119	2	the	the	DT
cord-001835-0s7ok4uw	1119	3	structure	structure	NN
cord-001835-0s7ok4uw	1119	4	of	of	IN
cord-001835-0s7ok4uw	1119	5	a	a	DT
cord-001835-0s7ok4uw	1119	6	protein	protein	NN
cord-001835-0s7ok4uw	1119	7	(	(	-LRB-
cord-001835-0s7ok4uw	1119	8	H3.1	H3.1	NNP
cord-001835-0s7ok4uw	1119	9	)	)	-RRB-
cord-001835-0s7ok4uw	1119	10	depend	depend	VB
cord-001835-0s7ok4uw	1119	11	on	on	IN
cord-001835-0s7ok4uw	1119	12	the	the	DT
cord-001835-0s7ok4uw	1119	13	treatment	treatment	NN
cord-001835-0s7ok4uw	1119	14	of	of	IN
cord-001835-0s7ok4uw	1119	15	a	a	DT
cord-001835-0s7ok4uw	1119	16	solvent	solvent	NN
cord-001835-0s7ok4uw	1119	17	medium	medium	NN
cord-001835-0s7ok4uw	1119	18	(	(	-LRB-
cord-001835-0s7ok4uw	1119	19	explicit	explicit	JJ
cord-001835-0s7ok4uw	1119	20	vs	vs	IN
cord-001835-0s7ok4uw	1119	21	effective	effective	JJ
cord-001835-0s7ok4uw	1119	22	)	)	-RRB-
cord-001835-0s7ok4uw	1119	23	in	in	IN
cord-001835-0s7ok4uw	1119	24	a	a	DT
cord-001835-0s7ok4uw	1119	25	coarse	coarse	RB
cord-001835-0s7ok4uw	1119	26	-	-	HYPH
cord-001835-0s7ok4uw	1119	27	grained	grained	JJ
cord-001835-0s7ok4uw	1119	28	computer	computer	NN
cord-001835-0s7ok4uw	1119	29	simulation	simulation	NN
cord-001835-0s7ok4uw	1119	30	?	?	.
cord-001835-0s7ok4uw	1120	1	Ras	Ras	NNP
cord-001835-0s7ok4uw	1120	2	Pandey	Pandey	NNP
cord-001835-0s7ok4uw	1120	3	1	1	CD
cord-001835-0s7ok4uw	1120	4	,	,	,
cord-001835-0s7ok4uw	1120	5	Barry	Barry	NNP
cord-001835-0s7ok4uw	1120	6	Farmer	Farmer	NNP
cord-001835-0s7ok4uw	1120	7	2	2	CD
cord-001835-0s7ok4uw	1120	8	1	1	CD
cord-001835-0s7ok4uw	1120	9	University	University	NNP
cord-001835-0s7ok4uw	1120	10	of	of	IN
cord-001835-0s7ok4uw	1120	11	Southern	Southern	NNP
cord-001835-0s7ok4uw	1120	12	Mississippi	Mississippi	NNP
cord-001835-0s7ok4uw	1120	13	,	,	,
cord-001835-0s7ok4uw	1120	14	2	2	CD
cord-001835-0s7ok4uw	1120	15	Air	Air	NNP
cord-001835-0s7ok4uw	1120	16	Force	Force	NNP
cord-001835-0s7ok4uw	1120	17	Research	Research	NNP
cord-001835-0s7ok4uw	1120	18	Laboratory	Laboratory	NNP
cord-001835-0s7ok4uw	1120	19	Solvent	Solvent	NNP
cord-001835-0s7ok4uw	1120	20	medium	medium	NN
cord-001835-0s7ok4uw	1120	21	plays	play	VBZ
cord-001835-0s7ok4uw	1120	22	a	a	DT
cord-001835-0s7ok4uw	1120	23	critical	critical	JJ
cord-001835-0s7ok4uw	1120	24	role	role	NN
cord-001835-0s7ok4uw	1120	25	in	in	IN
cord-001835-0s7ok4uw	1120	26	orchestrating	orchestrate	VBG
cord-001835-0s7ok4uw	1120	27	the	the	DT
cord-001835-0s7ok4uw	1120	28	structure	structure	NN
cord-001835-0s7ok4uw	1120	29	and	and	CC
cord-001835-0s7ok4uw	1120	30	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1120	31	of	of	IN
cord-001835-0s7ok4uw	1120	32	a	a	DT
cord-001835-0s7ok4uw	1120	33	protein	protein	NN
cord-001835-0s7ok4uw	1120	34	.	.	.
cord-001835-0s7ok4uw	1121	1	In	in	IN
cord-001835-0s7ok4uw	1121	2	computer	computer	NN
cord-001835-0s7ok4uw	1121	3	simulation	simulation	NN
cord-001835-0s7ok4uw	1121	4	modeling	modeling	NN
cord-001835-0s7ok4uw	1121	5	of	of	IN
cord-001835-0s7ok4uw	1121	6	protein	protein	NN
cord-001835-0s7ok4uw	1121	7	structure	structure	NN
cord-001835-0s7ok4uw	1121	8	in	in	IN
cord-001835-0s7ok4uw	1121	9	a	a	DT
cord-001835-0s7ok4uw	1121	10	solvent	solvent	NN
cord-001835-0s7ok4uw	1121	11	medium	medium	NN
cord-001835-0s7ok4uw	1121	12	,	,	,
cord-001835-0s7ok4uw	1121	13	explicit	explicit	JJ
cord-001835-0s7ok4uw	1121	14	,	,	,
cord-001835-0s7ok4uw	1121	15	implicit	implicit	JJ
cord-001835-0s7ok4uw	1121	16	,	,	,
cord-001835-0s7ok4uw	1121	17	effectivemedium	effectivemedium	NN
cord-001835-0s7ok4uw	1121	18	,	,	,
cord-001835-0s7ok4uw	1121	19	approaches	approach	NNS
cord-001835-0s7ok4uw	1121	20	are	be	VBP
cord-001835-0s7ok4uw	1121	21	often	often	RB
cord-001835-0s7ok4uw	1121	22	adopted	adopt	VBN
cord-001835-0s7ok4uw	1121	23	to	to	TO
cord-001835-0s7ok4uw	1121	24	incorporate	incorporate	VB
cord-001835-0s7ok4uw	1121	25	the	the	DT
cord-001835-0s7ok4uw	1121	26	effects	effect	NNS
cord-001835-0s7ok4uw	1121	27	of	of	IN
cord-001835-0s7ok4uw	1121	28	solvation	solvation	NN
cord-001835-0s7ok4uw	1121	29	.	.	.
cord-001835-0s7ok4uw	1122	1	Because	because	IN
cord-001835-0s7ok4uw	1122	2	of	of	IN
cord-001835-0s7ok4uw	1122	3	the	the	DT
cord-001835-0s7ok4uw	1122	4	complexity	complexity	NN
cord-001835-0s7ok4uw	1122	5	in	in	IN
cord-001835-0s7ok4uw	1122	6	incorporating	incorporate	VBG
cord-001835-0s7ok4uw	1122	7	all	all	DT
cord-001835-0s7ok4uw	1122	8	atomic	atomic	JJ
cord-001835-0s7ok4uw	1122	9	and	and	CC
cord-001835-0s7ok4uw	1122	10	molecular	molecular	JJ
cord-001835-0s7ok4uw	1122	11	details	detail	NNS
cord-001835-0s7ok4uw	1122	12	,	,	,
cord-001835-0s7ok4uw	1122	13	the	the	DT
cord-001835-0s7ok4uw	1122	14	multiple	multiple	JJ
cord-001835-0s7ok4uw	1122	15	components	component	NNS
cord-001835-0s7ok4uw	1122	16	,	,	,
cord-001835-0s7ok4uw	1122	17	reaching	reach	VBG
cord-001835-0s7ok4uw	1122	18	the	the	DT
cord-001835-0s7ok4uw	1122	19	large	large	JJ
cord-001835-0s7ok4uw	1122	20	-	-	HYPH
cord-001835-0s7ok4uw	1122	21	scale	scale	NN
cord-001835-0s7ok4uw	1122	22	,	,	,
cord-001835-0s7ok4uw	1122	23	etc	etc	FW
cord-001835-0s7ok4uw	1122	24	.	.	.
cord-001835-0s7ok4uw	1123	1	implicit	implicit	JJ
cord-001835-0s7ok4uw	1123	2	solvent	solvent	NN
cord-001835-0s7ok4uw	1123	3	or	or	CC
cord-001835-0s7ok4uw	1123	4	effective	effective	JJ
cord-001835-0s7ok4uw	1123	5	medium	medium	JJ
cord-001835-0s7ok4uw	1123	6	approach	approach	NN
cord-001835-0s7ok4uw	1123	7	is	be	VBZ
cord-001835-0s7ok4uw	1123	8	generally	generally	RB
cord-001835-0s7ok4uw	1123	9	more	more	RBR
cord-001835-0s7ok4uw	1123	10	viable	viable	JJ
cord-001835-0s7ok4uw	1123	11	than	than	IN
cord-001835-0s7ok4uw	1123	12	the	the	DT
cord-001835-0s7ok4uw	1123	13	explicit	explicit	JJ
cord-001835-0s7ok4uw	1123	14	solvent	solvent	NN
cord-001835-0s7ok4uw	1123	15	methods	method	NNS
cord-001835-0s7ok4uw	1123	16	.	.	.
cord-001835-0s7ok4uw	1124	1	Some	some	DT
cord-001835-0s7ok4uw	1124	2	of	of	IN
cord-001835-0s7ok4uw	1124	3	the	the	DT
cord-001835-0s7ok4uw	1124	4	pertinent	pertinent	JJ
cord-001835-0s7ok4uw	1124	5	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	1124	6	such	such	JJ
cord-001835-0s7ok4uw	1124	7	as	as	IN
cord-001835-0s7ok4uw	1124	8	excluded	exclude	VBN
cord-001835-0s7ok4uw	1124	9	volume	volume	NN
cord-001835-0s7ok4uw	1124	10	of	of	IN
cord-001835-0s7ok4uw	1124	11	the	the	DT
cord-001835-0s7ok4uw	1124	12	solvent	solvent	NN
cord-001835-0s7ok4uw	1124	13	constituents	constituent	NNS
cord-001835-0s7ok4uw	1124	14	,	,	,
cord-001835-0s7ok4uw	1124	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1124	16	concentration	concentration	NN
cord-001835-0s7ok4uw	1124	17	,	,	,
cord-001835-0s7ok4uw	1124	18	and	and	CC
cord-001835-0s7ok4uw	1124	19	the	the	DT
cord-001835-0s7ok4uw	1124	20	underlying	underlying	JJ
cord-001835-0s7ok4uw	1124	21	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	1124	22	which	which	WDT
cord-001835-0s7ok4uw	1124	23	may	may	MD
cord-001835-0s7ok4uw	1124	24	be	be	VB
cord-001835-0s7ok4uw	1124	25	important	important	JJ
cord-001835-0s7ok4uw	1124	26	in	in	IN
cord-001835-0s7ok4uw	1124	27	probing	probe	VBG
cord-001835-0s7ok4uw	1124	28	some	some	DT
cord-001835-0s7ok4uw	1124	29	issues	issue	NNS
cord-001835-0s7ok4uw	1124	30	are	be	VBP
cord-001835-0s7ok4uw	1124	31	generally	generally	RB
cord-001835-0s7ok4uw	1124	32	ignored	ignore	VBN
cord-001835-0s7ok4uw	1124	33	in	in	IN
cord-001835-0s7ok4uw	1124	34	effective	effective	JJ
cord-001835-0s7ok4uw	1124	35	medium	medium	NN
cord-001835-0s7ok4uw	1124	36	or	or	CC
cord-001835-0s7ok4uw	1124	37	implicit	implicit	JJ
cord-001835-0s7ok4uw	1124	38	solvent	solvent	NN
cord-001835-0s7ok4uw	1124	39	approaches	approach	NNS
cord-001835-0s7ok4uw	1124	40	.	.	.
cord-001835-0s7ok4uw	1125	1	Using	use	VBG
cord-001835-0s7ok4uw	1125	2	a	a	DT
cord-001835-0s7ok4uw	1125	3	coarse	coarse	RB
cord-001835-0s7ok4uw	1125	4	-	-	HYPH
cord-001835-0s7ok4uw	1125	5	grained	grained	JJ
cord-001835-0s7ok4uw	1125	6	approach	approach	NN
cord-001835-0s7ok4uw	1125	7	,	,	,
cord-001835-0s7ok4uw	1125	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	1125	9	investigate	investigate	VBP
cord-001835-0s7ok4uw	1125	10	the	the	DT
cord-001835-0s7ok4uw	1125	11	structure	structure	NN
cord-001835-0s7ok4uw	1125	12	and	and	CC
cord-001835-0s7ok4uw	1125	13	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1125	14	of	of	IN
cord-001835-0s7ok4uw	1125	15	a	a	DT
cord-001835-0s7ok4uw	1125	16	protein	protein	NN
cord-001835-0s7ok4uw	1125	17	(	(	-LRB-
cord-001835-0s7ok4uw	1125	18	a	a	DT
cord-001835-0s7ok4uw	1125	19	histone	histone	NN
cord-001835-0s7ok4uw	1125	20	,	,	,
cord-001835-0s7ok4uw	1125	21	H3.1	H3.1	NNP
cord-001835-0s7ok4uw	1125	22	)	)	-RRB-
cord-001835-0s7ok4uw	1125	23	in	in	IN
cord-001835-0s7ok4uw	1125	24	the	the	DT
cord-001835-0s7ok4uw	1125	25	presence	presence	NN
cord-001835-0s7ok4uw	1125	26	of	of	IN
cord-001835-0s7ok4uw	1125	27	both	both	DT
cord-001835-0s7ok4uw	1125	28	effective	effective	JJ
cord-001835-0s7ok4uw	1125	29	as	as	RB
cord-001835-0s7ok4uw	1125	30	well	well	RB
cord-001835-0s7ok4uw	1125	31	as	as	IN
cord-001835-0s7ok4uw	1125	32	explicit	explicit	JJ
cord-001835-0s7ok4uw	1125	33	solvent	solvent	NN
cord-001835-0s7ok4uw	1125	34	media	medium	NNS
cord-001835-0s7ok4uw	1125	35	over	over	IN
cord-001835-0s7ok4uw	1125	36	a	a	DT
cord-001835-0s7ok4uw	1125	37	range	range	NN
cord-001835-0s7ok4uw	1125	38	of	of	IN
cord-001835-0s7ok4uw	1125	39	temperatures	temperature	NNS
cord-001835-0s7ok4uw	1125	40	with	with	IN
cord-001835-0s7ok4uw	1125	41	the	the	DT
cord-001835-0s7ok4uw	1125	42	Monte	Monte	NNP
cord-001835-0s7ok4uw	1125	43	Carlo	Carlo	NNP
cord-001835-0s7ok4uw	1125	44	simulations	simulation	NNS
cord-001835-0s7ok4uw	1125	45	.	.	.
cord-001835-0s7ok4uw	1126	1	The	the	DT
cord-001835-0s7ok4uw	1126	2	protein	protein	NN
cord-001835-0s7ok4uw	1126	3	is	be	VBZ
cord-001835-0s7ok4uw	1126	4	represented	represent	VBN
cord-001835-0s7ok4uw	1126	5	by	by	IN
cord-001835-0s7ok4uw	1126	6	a	a	DT
cord-001835-0s7ok4uw	1126	7	coarse	coarse	RB
cord-001835-0s7ok4uw	1126	8	-	-	HYPH
cord-001835-0s7ok4uw	1126	9	grained	grained	JJ
cord-001835-0s7ok4uw	1126	10	chain	chain	NN
cord-001835-0s7ok4uw	1126	11	of	of	IN
cord-001835-0s7ok4uw	1126	12	residues	residue	NNS
cord-001835-0s7ok4uw	1126	13	whose	whose	WP$
cord-001835-0s7ok4uw	1126	14	interactions	interaction	NNS
cord-001835-0s7ok4uw	1126	15	are	be	VBP
cord-001835-0s7ok4uw	1126	16	described	describe	VBN
cord-001835-0s7ok4uw	1126	17	by	by	IN
cord-001835-0s7ok4uw	1126	18	knowledge	knowledge	NN
cord-001835-0s7ok4uw	1126	19	-	-	HYPH
cord-001835-0s7ok4uw	1126	20	based	base	VBN
cord-001835-0s7ok4uw	1126	21	residue	residue	NN
cord-001835-0s7ok4uw	1126	22	-	-	HYPH
cord-001835-0s7ok4uw	1126	23	residue	residue	NN
cord-001835-0s7ok4uw	1126	24	and	and	CC
cord-001835-0s7ok4uw	1126	25	hydropathy	hydropathy	JJ
cord-001835-0s7ok4uw	1126	26	-	-	HYPH
cord-001835-0s7ok4uw	1126	27	index	index	NN
cord-001835-0s7ok4uw	1126	28	-	-	HYPH
cord-001835-0s7ok4uw	1126	29	based	base	VBN
cord-001835-0s7ok4uw	1126	30	residuesolvent	residuesolvent	NN
cord-001835-0s7ok4uw	1126	31	interactions	interaction	NNS
cord-001835-0s7ok4uw	1126	32	.	.	.
cord-001835-0s7ok4uw	1127	1	In	in	IN
cord-001835-0s7ok4uw	1127	2	effective	effective	JJ
cord-001835-0s7ok4uw	1127	3	medium	medium	NN
cord-001835-0s7ok4uw	1127	4	approach	approach	NN
cord-001835-0s7ok4uw	1127	5	,	,	,
cord-001835-0s7ok4uw	1127	6	each	each	DT
cord-001835-0s7ok4uw	1127	7	empty	empty	JJ
cord-001835-0s7ok4uw	1127	8	lattice	lattice	NN
cord-001835-0s7ok4uw	1127	9	site	site	NN
cord-001835-0s7ok4uw	1127	10	around	around	IN
cord-001835-0s7ok4uw	1127	11	the	the	DT
cord-001835-0s7ok4uw	1127	12	protein	protein	NN
cord-001835-0s7ok4uw	1127	13	structure	structure	NN
cord-001835-0s7ok4uw	1127	14	acts	act	VBZ
cord-001835-0s7ok4uw	1127	15	as	as	IN
cord-001835-0s7ok4uw	1127	16	a	a	DT
cord-001835-0s7ok4uw	1127	17	solvent	solvent	NN
cord-001835-0s7ok4uw	1127	18	.	.	.
cord-001835-0s7ok4uw	1128	1	Only	only	RB
cord-001835-0s7ok4uw	1128	2	a	a	DT
cord-001835-0s7ok4uw	1128	3	fraction	fraction	NN
cord-001835-0s7ok4uw	1128	4	of	of	IN
cord-001835-0s7ok4uw	1128	5	lattice	lattice	NN
cord-001835-0s7ok4uw	1128	6	sites	site	NNS
cord-001835-0s7ok4uw	1128	7	are	be	VBP
cord-001835-0s7ok4uw	1128	8	occupied	occupy	VBN
cord-001835-0s7ok4uw	1128	9	by	by	IN
cord-001835-0s7ok4uw	1128	10	mobile	mobile	JJ
cord-001835-0s7ok4uw	1128	11	solvent	solvent	NN
cord-001835-0s7ok4uw	1128	12	constituents	constituent	NNS
cord-001835-0s7ok4uw	1128	13	along	along	IN
cord-001835-0s7ok4uw	1128	14	with	with	IN
cord-001835-0s7ok4uw	1128	15	the	the	DT
cord-001835-0s7ok4uw	1128	16	protein	protein	NN
cord-001835-0s7ok4uw	1128	17	chain	chain	NN
cord-001835-0s7ok4uw	1128	18	in	in	IN
cord-001835-0s7ok4uw	1128	19	explicit	explicit	JJ
cord-001835-0s7ok4uw	1128	20	solvent	solvent	NN
cord-001835-0s7ok4uw	1128	21	medium	medium	NN
cord-001835-0s7ok4uw	1128	22	.	.	.
cord-001835-0s7ok4uw	1129	1	Large	large	JJ
cord-001835-0s7ok4uw	1129	2	scale	scale	NN
cord-001835-0s7ok4uw	1129	3	simulations	simulation	NNS
cord-001835-0s7ok4uw	1129	4	are	be	VBP
cord-001835-0s7ok4uw	1129	5	performed	perform	VBN
cord-001835-0s7ok4uw	1129	6	to	to	TO
cord-001835-0s7ok4uw	1129	7	analyze	analyze	VB
cord-001835-0s7ok4uw	1129	8	the	the	DT
cord-001835-0s7ok4uw	1129	9	structure	structure	NN
cord-001835-0s7ok4uw	1129	10	of	of	IN
cord-001835-0s7ok4uw	1129	11	the	the	DT
cord-001835-0s7ok4uw	1129	12	protein	protein	NN
cord-001835-0s7ok4uw	1129	13	for	for	IN
cord-001835-0s7ok4uw	1129	14	a	a	DT
cord-001835-0s7ok4uw	1129	15	range	range	NN
cord-001835-0s7ok4uw	1129	16	of	of	IN
cord-001835-0s7ok4uw	1129	17	residue	residue	NN
cord-001835-0s7ok4uw	1129	18	-	-	HYPH
cord-001835-0s7ok4uw	1129	19	solvent	solvent	NN
cord-001835-0s7ok4uw	1129	20	interactions	interaction	NNS
cord-001835-0s7ok4uw	1129	21	and	and	CC
cord-001835-0s7ok4uw	1129	22	temperature	temperature	NN
cord-001835-0s7ok4uw	1129	23	in	in	IN
cord-001835-0s7ok4uw	1129	24	both	both	DT
cord-001835-0s7ok4uw	1129	25	explicit	explicit	JJ
cord-001835-0s7ok4uw	1129	26	and	and	CC
cord-001835-0s7ok4uw	1129	27	effective	effective	JJ
cord-001835-0s7ok4uw	1129	28	solvent	solvent	NN
cord-001835-0s7ok4uw	1129	29	media	medium	NNS
cord-001835-0s7ok4uw	1129	30	.	.	.
cord-001835-0s7ok4uw	1130	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1130	2	study	study	VBP
cord-001835-0s7ok4uw	1130	3	a	a	DT
cord-001835-0s7ok4uw	1130	4	number	number	NN
cord-001835-0s7ok4uw	1130	5	of	of	IN
cord-001835-0s7ok4uw	1130	6	local	local	JJ
cord-001835-0s7ok4uw	1130	7	(	(	-LRB-
cord-001835-0s7ok4uw	1130	8	e.g.	e.g.	IN
cord-001835-0s7ok4uw	1130	9	solvation	solvation	NN
cord-001835-0s7ok4uw	1130	10	and	and	CC
cord-001835-0s7ok4uw	1130	11	mobility	mobility	NN
cord-001835-0s7ok4uw	1130	12	profiles	profile	NNS
cord-001835-0s7ok4uw	1130	13	)	)	-RRB-
cord-001835-0s7ok4uw	1130	14	and	and	CC
cord-001835-0s7ok4uw	1130	15	global	global	JJ
cord-001835-0s7ok4uw	1130	16	(	(	-LRB-
cord-001835-0s7ok4uw	1130	17	radius	radius	NN
cord-001835-0s7ok4uw	1130	18	of	of	IN
cord-001835-0s7ok4uw	1130	19	gyration	gyration	NN
cord-001835-0s7ok4uw	1130	20	and	and	CC
cord-001835-0s7ok4uw	1130	21	structure	structure	NN
cord-001835-0s7ok4uw	1130	22	factor	factor	NN
cord-001835-0s7ok4uw	1130	23	)	)	-RRB-
cord-001835-0s7ok4uw	1131	1	physical	physical	JJ
cord-001835-0s7ok4uw	1131	2	quantities	quantity	NNS
cord-001835-0s7ok4uw	1131	3	as	as	IN
cord-001835-0s7ok4uw	1131	4	a	a	DT
cord-001835-0s7ok4uw	1131	5	function	function	NN
cord-001835-0s7ok4uw	1131	6	of	of	IN
cord-001835-0s7ok4uw	1131	7	temperature	temperature	NN
cord-001835-0s7ok4uw	1131	8	.	.	.
cord-001835-0s7ok4uw	1132	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1132	2	find	find	VBP
cord-001835-0s7ok4uw	1132	3	that	that	IN
cord-001835-0s7ok4uw	1132	4	the	the	DT
cord-001835-0s7ok4uw	1132	5	response	response	NN
cord-001835-0s7ok4uw	1132	6	of	of	IN
cord-001835-0s7ok4uw	1132	7	the	the	DT
cord-001835-0s7ok4uw	1132	8	radius	radius	NN
cord-001835-0s7ok4uw	1132	9	of	of	IN
cord-001835-0s7ok4uw	1132	10	gyration	gyration	NN
cord-001835-0s7ok4uw	1132	11	of	of	IN
cord-001835-0s7ok4uw	1132	12	the	the	DT
cord-001835-0s7ok4uw	1132	13	protein	protein	NN
cord-001835-0s7ok4uw	1132	14	in	in	IN
cord-001835-0s7ok4uw	1132	15	explicit	explicit	JJ
cord-001835-0s7ok4uw	1132	16	solvent	solvent	NN
cord-001835-0s7ok4uw	1132	17	is	be	VBZ
cord-001835-0s7ok4uw	1132	18	different	different	JJ
cord-001835-0s7ok4uw	1132	19	from	from	IN
cord-001835-0s7ok4uw	1132	20	that	that	DT
cord-001835-0s7ok4uw	1132	21	in	in	IN
cord-001835-0s7ok4uw	1132	22	effective	effective	JJ
cord-001835-0s7ok4uw	1132	23	medium	medium	NN
cord-001835-0s7ok4uw	1132	24	solvent	solvent	NN
cord-001835-0s7ok4uw	1132	25	.	.	.
cord-001835-0s7ok4uw	1133	1	Thus	thus	RB
cord-001835-0s7ok4uw	1133	2	,	,	,
cord-001835-0s7ok4uw	1133	3	the	the	DT
cord-001835-0s7ok4uw	1133	4	presence	presence	NN
cord-001835-0s7ok4uw	1133	5	of	of	IN
cord-001835-0s7ok4uw	1133	6	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	1133	7	in	in	IN
cord-001835-0s7ok4uw	1133	8	explicit	explicit	JJ
cord-001835-0s7ok4uw	1133	9	solvent	solvent	NN
cord-001835-0s7ok4uw	1133	10	approach	approach	NN
cord-001835-0s7ok4uw	1133	11	have	have	VBP
cord-001835-0s7ok4uw	1133	12	considerable	considerable	JJ
cord-001835-0s7ok4uw	1133	13	effects	effect	NNS
cord-001835-0s7ok4uw	1133	14	on	on	IN
cord-001835-0s7ok4uw	1133	15	the	the	DT
cord-001835-0s7ok4uw	1133	16	structure	structure	NN
cord-001835-0s7ok4uw	1133	17	and	and	CC
cord-001835-0s7ok4uw	1133	18	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1133	19	of	of	IN
cord-001835-0s7ok4uw	1133	20	protein	protein	NN
cord-001835-0s7ok4uw	1133	21	H3.1	H3.1	NNP
cord-001835-0s7ok4uw	1133	22	.	.	.
cord-001835-0s7ok4uw	1134	1	Differences	difference	NNS
cord-001835-0s7ok4uw	1134	2	due	due	JJ
cord-001835-0s7ok4uw	1134	3	to	to	IN
cord-001835-0s7ok4uw	1134	4	type	type	NN
cord-001835-0s7ok4uw	1134	5	of	of	IN
cord-001835-0s7ok4uw	1134	6	solvent	solvent	NN
cord-001835-0s7ok4uw	1134	7	on	on	IN
cord-001835-0s7ok4uw	1134	8	the	the	DT
cord-001835-0s7ok4uw	1134	9	response	response	NN
cord-001835-0s7ok4uw	1134	10	of	of	IN
cord-001835-0s7ok4uw	1134	11	some	some	DT
cord-001835-0s7ok4uw	1134	12	of	of	IN
cord-001835-0s7ok4uw	1134	13	these	these	DT
cord-001835-0s7ok4uw	1134	14	quantities	quantity	NNS
cord-001835-0s7ok4uw	1134	15	as	as	IN
cord-001835-0s7ok4uw	1134	16	a	a	DT
cord-001835-0s7ok4uw	1134	17	function	function	NN
cord-001835-0s7ok4uw	1134	18	of	of	IN
cord-001835-0s7ok4uw	1134	19	temperature	temperature	NN
cord-001835-0s7ok4uw	1134	20	as	as	RB
cord-001835-0s7ok4uw	1134	21	well	well	RB
cord-001835-0s7ok4uw	1134	22	as	as	IN
cord-001835-0s7ok4uw	1134	23	general	general	JJ
cord-001835-0s7ok4uw	1134	24	similarities	similarity	NNS
cord-001835-0s7ok4uw	1134	25	will	will	MD
cord-001835-0s7ok4uw	1134	26	be	be	VB
cord-001835-0s7ok4uw	1134	27	presented	present	VBN
cord-001835-0s7ok4uw	1134	28	.	.	.
cord-001835-0s7ok4uw	1135	1	Single	single	JJ
cord-001835-0s7ok4uw	1135	2	-	-	HYPH
cord-001835-0s7ok4uw	1135	3	molecule	molecule	NN
cord-001835-0s7ok4uw	1135	4	vectorial	vectorial	JJ
cord-001835-0s7ok4uw	1135	5	folding	folding	NN
cord-001835-0s7ok4uw	1135	6	and	and	CC
cord-001835-0s7ok4uw	1135	7	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1135	8	through	through	IN
cord-001835-0s7ok4uw	1135	9	membrane	membrane	NN
cord-001835-0s7ok4uw	1135	10	pores	pore	NNS
cord-001835-0s7ok4uw	1135	11	David	David	NNP
cord-001835-0s7ok4uw	1135	12	Protein	Protein	NNP
cord-001835-0s7ok4uw	1135	13	folding	folding	NN
cord-001835-0s7ok4uw	1135	14	and	and	CC
cord-001835-0s7ok4uw	1135	15	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1135	16	in	in	IN
cord-001835-0s7ok4uw	1135	17	vivo	vivo	NNP
cord-001835-0s7ok4uw	1135	18	is	be	VBZ
cord-001835-0s7ok4uw	1135	19	frequently	frequently	RB
cord-001835-0s7ok4uw	1135	20	vectorial	vectorial	JJ
cord-001835-0s7ok4uw	1135	21	.	.	.
cord-001835-0s7ok4uw	1136	1	For	for	IN
cord-001835-0s7ok4uw	1136	2	example	example	NN
cord-001835-0s7ok4uw	1136	3	,	,	,
cord-001835-0s7ok4uw	1136	4	proteins	protein	NNS
cord-001835-0s7ok4uw	1136	5	are	be	VBP
cord-001835-0s7ok4uw	1136	6	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	1136	7	at	at	IN
cord-001835-0s7ok4uw	1136	8	the	the	DT
cord-001835-0s7ok4uw	1136	9	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1136	10	and	and	CC
cord-001835-0s7ok4uw	1136	11	emerge	emerge	VB
cord-001835-0s7ok4uw	1136	12	N	n	CD
cord-001835-0s7ok4uw	1136	13	-	-	HYPH
cord-001835-0s7ok4uw	1136	14	terminal	terminal	NN
cord-001835-0s7ok4uw	1136	15	first	first	RB
cord-001835-0s7ok4uw	1136	16	.	.	.
cord-001835-0s7ok4uw	1137	1	As	as	IN
cord-001835-0s7ok4uw	1137	2	the	the	DT
cord-001835-0s7ok4uw	1137	3	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	1137	4	chain	chain	NN
cord-001835-0s7ok4uw	1137	5	emerges	emerge	VBZ
cord-001835-0s7ok4uw	1137	6	from	from	IN
cord-001835-0s7ok4uw	1137	7	a	a	DT
cord-001835-0s7ok4uw	1137	8	2	2	CD
cord-001835-0s7ok4uw	1137	9	nm	nm	NN
cord-001835-0s7ok4uw	1137	10	wide	wide	JJ
cord-001835-0s7ok4uw	1137	11	pore	pore	NN
cord-001835-0s7ok4uw	1137	12	is	be	VBZ
cord-001835-0s7ok4uw	1137	13	free	free	JJ
cord-001835-0s7ok4uw	1137	14	to	to	TO
cord-001835-0s7ok4uw	1137	15	fold	fold	VB
cord-001835-0s7ok4uw	1137	16	,	,	,
cord-001835-0s7ok4uw	1137	17	interact	interact	VB
cord-001835-0s7ok4uw	1137	18	with	with	IN
cord-001835-0s7ok4uw	1137	19	partners	partner	NNS
cord-001835-0s7ok4uw	1137	20	or	or	CC
cord-001835-0s7ok4uw	1137	21	misfold1	misfold1	NN
cord-001835-0s7ok4uw	1137	22	.	.	.
cord-001835-0s7ok4uw	1138	1	In	in	IN
cord-001835-0s7ok4uw	1138	2	another	another	DT
cord-001835-0s7ok4uw	1138	3	example	example	NN
cord-001835-0s7ok4uw	1138	4	,	,	,
cord-001835-0s7ok4uw	1138	5	proteins	protein	NNS
cord-001835-0s7ok4uw	1138	6	are	be	VBP
cord-001835-0s7ok4uw	1138	7	unfolded	unfold	VBN
cord-001835-0s7ok4uw	1138	8	at	at	IN
cord-001835-0s7ok4uw	1138	9	the	the	DT
cord-001835-0s7ok4uw	1138	10	proteasome	proteasome	NN
cord-001835-0s7ok4uw	1138	11	by	by	IN
cord-001835-0s7ok4uw	1138	12	pulling	pull	VBG
cord-001835-0s7ok4uw	1138	13	from	from	IN
cord-001835-0s7ok4uw	1138	14	either	either	CC
cord-001835-0s7ok4uw	1138	15	the	the	DT
cord-001835-0s7ok4uw	1138	16	N	N	NNP
cord-001835-0s7ok4uw	1138	17	or	or	CC
cord-001835-0s7ok4uw	1138	18	C	C	NNP
cord-001835-0s7ok4uw	1138	19	terminus	terminus	NN
cord-001835-0s7ok4uw	1138	20	against	against	IN
cord-001835-0s7ok4uw	1138	21	a	a	DT
cord-001835-0s7ok4uw	1138	22	1	1	CD
cord-001835-0s7ok4uw	1138	23	-	-	SYM
cord-001835-0s7ok4uw	1138	24	2	2	CD
cord-001835-0s7ok4uw	1138	25	nm	nm	NN
cord-001835-0s7ok4uw	1138	26	wide	wide	JJ
cord-001835-0s7ok4uw	1138	27	pore	pore	NN
cord-001835-0s7ok4uw	1138	28	,	,	,
cord-001835-0s7ok4uw	1138	29	applying	apply	VBG
cord-001835-0s7ok4uw	1138	30	a	a	DT
cord-001835-0s7ok4uw	1138	31	tension	tension	NN
cord-001835-0s7ok4uw	1138	32	on	on	IN
cord-001835-0s7ok4uw	1138	33	the	the	DT
cord-001835-0s7ok4uw	1138	34	residues	residue	NNS
cord-001835-0s7ok4uw	1138	35	surrounding	surround	VBG
cord-001835-0s7ok4uw	1138	36	the	the	DT
cord-001835-0s7ok4uw	1138	37	terminus	terminus	NN
cord-001835-0s7ok4uw	1138	38	of	of	IN
cord-001835-0s7ok4uw	1138	39	the	the	DT
cord-001835-0s7ok4uw	1138	40	protein2	protein2	NN
cord-001835-0s7ok4uw	1138	41	.	.	.
cord-001835-0s7ok4uw	1139	1	Under	under	IN
cord-001835-0s7ok4uw	1139	2	this	this	DT
cord-001835-0s7ok4uw	1139	3	conditions	condition	NNS
cord-001835-0s7ok4uw	1139	4	,	,	,
cord-001835-0s7ok4uw	1139	5	proteins	protein	NNS
cord-001835-0s7ok4uw	1139	6	may	may	MD
cord-001835-0s7ok4uw	1139	7	behave	behave	VB
cord-001835-0s7ok4uw	1139	8	differently	differently	RB
cord-001835-0s7ok4uw	1139	9	than	than	IN
cord-001835-0s7ok4uw	1139	10	when	when	WRB
cord-001835-0s7ok4uw	1139	11	unfolded	unfold	VBN
cord-001835-0s7ok4uw	1139	12	/	/	SYM
cord-001835-0s7ok4uw	1139	13	refolded	refolde	VBD
cord-001835-0s7ok4uw	1139	14	with	with	IN
cord-001835-0s7ok4uw	1139	15	temperature	temperature	NN
cord-001835-0s7ok4uw	1139	16	or	or	CC
cord-001835-0s7ok4uw	1139	17	urea	urea	NN
cord-001835-0s7ok4uw	1139	18	.	.	.
cord-001835-0s7ok4uw	1140	1	This	this	DT
cord-001835-0s7ok4uw	1140	2	may	may	MD
cord-001835-0s7ok4uw	1140	3	have	have	VB
cord-001835-0s7ok4uw	1140	4	important	important	JJ
cord-001835-0s7ok4uw	1140	5	implications	implication	NNS
cord-001835-0s7ok4uw	1140	6	,	,	,
cord-001835-0s7ok4uw	1140	7	as	as	IN
cord-001835-0s7ok4uw	1140	8	protein	protein	NN
cord-001835-0s7ok4uw	1140	9	folding	folding	NN
cord-001835-0s7ok4uw	1140	10	and	and	CC
cord-001835-0s7ok4uw	1140	11	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1140	12	in	in	IN
cord-001835-0s7ok4uw	1140	13	vivo	vivo	NNP
cord-001835-0s7ok4uw	1140	14	is	be	VBZ
cord-001835-0s7ok4uw	1140	15	related	relate	VBN
cord-001835-0s7ok4uw	1140	16	to	to	IN
cord-001835-0s7ok4uw	1140	17	both	both	DT
cord-001835-0s7ok4uw	1140	18	function	function	NN
cord-001835-0s7ok4uw	1140	19	and	and	CC
cord-001835-0s7ok4uw	1140	20	disease	disease	NN
cord-001835-0s7ok4uw	1140	21	.	.	.
cord-001835-0s7ok4uw	1141	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1141	2	noticed	notice	VBD
cord-001835-0s7ok4uw	1141	3	that	that	IN
cord-001835-0s7ok4uw	1141	4	vectorial	vectorial	JJ
cord-001835-0s7ok4uw	1141	5	folding	folding	NN
cord-001835-0s7ok4uw	1141	6	is	be	VBZ
cord-001835-0s7ok4uw	1141	7	inherently	inherently	RB
cord-001835-0s7ok4uw	1141	8	linked	link	VBN
cord-001835-0s7ok4uw	1141	9	to	to	IN
cord-001835-0s7ok4uw	1141	10	nanometer	nanometer	NN
cord-001835-0s7ok4uw	1141	11	size	size	NN
cord-001835-0s7ok4uw	1141	12	pores	pore	NNS
cord-001835-0s7ok4uw	1141	13	.	.	.
cord-001835-0s7ok4uw	1142	1	Making	make	VBG
cord-001835-0s7ok4uw	1142	2	use	use	NN
cord-001835-0s7ok4uw	1142	3	of	of	IN
cord-001835-0s7ok4uw	1142	4	nanopore	nanopore	NNP
cord-001835-0s7ok4uw	1142	5	technology	technology	NN
cord-001835-0s7ok4uw	1142	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	1142	7	developed	develop	VBD
cord-001835-0s7ok4uw	1142	8	a	a	DT
cord-001835-0s7ok4uw	1142	9	method	method	NN
cord-001835-0s7ok4uw	1142	10	to	to	TO
cord-001835-0s7ok4uw	1142	11	monitor	monitor	VB
cord-001835-0s7ok4uw	1142	12	protein	protein	NN
cord-001835-0s7ok4uw	1142	13	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1142	14	during	during	IN
cord-001835-0s7ok4uw	1142	15	membrane	membrane	NN
cord-001835-0s7ok4uw	1142	16	translocation	translocation	NN
cord-001835-0s7ok4uw	1142	17	at	at	IN
cord-001835-0s7ok4uw	1142	18	the	the	DT
cord-001835-0s7ok4uw	1142	19	single	single	JJ
cord-001835-0s7ok4uw	1142	20	-	-	HYPH
cord-001835-0s7ok4uw	1142	21	molecule	molecule	NN
cord-001835-0s7ok4uw	1142	22	level3	level3	NN
cord-001835-0s7ok4uw	1142	23	.	.	.
cord-001835-0s7ok4uw	1143	1	Briefly	briefly	RB
cord-001835-0s7ok4uw	1143	2	,	,	,
cord-001835-0s7ok4uw	1143	3	an	an	DT
cord-001835-0s7ok4uw	1143	4	oligonucleotide	oligonucleotide	NN
cord-001835-0s7ok4uw	1143	5	attached	attach	VBN
cord-001835-0s7ok4uw	1143	6	at	at	IN
cord-001835-0s7ok4uw	1143	7	either	either	DT
cord-001835-0s7ok4uw	1143	8	end	end	NN
cord-001835-0s7ok4uw	1143	9	of	of	IN
cord-001835-0s7ok4uw	1143	10	a	a	DT
cord-001835-0s7ok4uw	1143	11	protein	protein	NN
cord-001835-0s7ok4uw	1143	12	threads	thread	VBZ
cord-001835-0s7ok4uw	1143	13	a	a	DT
cord-001835-0s7ok4uw	1143	14	single	single	JJ
cord-001835-0s7ok4uw	1143	15	protein	protein	NN
cord-001835-0s7ok4uw	1143	16	nanopore	nanopore	NN
cord-001835-0s7ok4uw	1143	17	inserted	insert	VBN
cord-001835-0s7ok4uw	1143	18	in	in	IN
cord-001835-0s7ok4uw	1143	19	a	a	DT
cord-001835-0s7ok4uw	1143	20	lipid	lipid	NN
cord-001835-0s7ok4uw	1143	21	membrane	membrane	NN
cord-001835-0s7ok4uw	1143	22	.	.	.
cord-001835-0s7ok4uw	1144	1	In	in	IN
cord-001835-0s7ok4uw	1144	2	response	response	NN
cord-001835-0s7ok4uw	1144	3	to	to	IN
cord-001835-0s7ok4uw	1144	4	an	an	DT
cord-001835-0s7ok4uw	1144	5	applied	apply	VBN
cord-001835-0s7ok4uw	1144	6	membrane	membrane	NN
cord-001835-0s7ok4uw	1144	7	potential	potential	NN
cord-001835-0s7ok4uw	1144	8	,	,	,
cord-001835-0s7ok4uw	1144	9	the	the	DT
cord-001835-0s7ok4uw	1144	10	oligonucleotide	oligonucleotide	NN
cord-001835-0s7ok4uw	1144	11	pulls	pull	VBZ
cord-001835-0s7ok4uw	1144	12	the	the	DT
cord-001835-0s7ok4uw	1144	13	protein	protein	NN
cord-001835-0s7ok4uw	1144	14	through	through	IN
cord-001835-0s7ok4uw	1144	15	the	the	DT
cord-001835-0s7ok4uw	1144	16	pore	pore	NN
cord-001835-0s7ok4uw	1144	17	and	and	CC
cord-001835-0s7ok4uw	1144	18	as	as	IN
cord-001835-0s7ok4uw	1144	19	it	-PRON-	PRP
cord-001835-0s7ok4uw	1144	20	is	be	VBZ
cord-001835-0s7ok4uw	1144	21	forced	force	VBN
cord-001835-0s7ok4uw	1144	22	to	to	TO
cord-001835-0s7ok4uw	1144	23	translocate	translocate	VB
cord-001835-0s7ok4uw	1144	24	it	-PRON-	PRP
cord-001835-0s7ok4uw	1144	25	unfolds	unfold	VBZ
cord-001835-0s7ok4uw	1144	26	.	.	.
cord-001835-0s7ok4uw	1145	1	Analysing	analyse	VBG
cord-001835-0s7ok4uw	1145	2	the	the	DT
cord-001835-0s7ok4uw	1145	3	ionic	ionic	JJ
cord-001835-0s7ok4uw	1145	4	current	current	NN
cord-001835-0s7ok4uw	1145	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1145	6	obtain	obtain	VBP
cord-001835-0s7ok4uw	1145	7	the	the	DT
cord-001835-0s7ok4uw	1145	8	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1145	9	pathway	pathway	NN
cord-001835-0s7ok4uw	1145	10	and	and	CC
cord-001835-0s7ok4uw	1145	11	information	information	NN
cord-001835-0s7ok4uw	1145	12	on	on	IN
cord-001835-0s7ok4uw	1145	13	the	the	DT
cord-001835-0s7ok4uw	1145	14	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	1145	15	sequence	sequence	NN
cord-001835-0s7ok4uw	1145	16	.	.	.
cord-001835-0s7ok4uw	1146	1	This	this	DT
cord-001835-0s7ok4uw	1146	2	methodology	methodology	NN
cord-001835-0s7ok4uw	1146	3	has	have	VBZ
cord-001835-0s7ok4uw	1146	4	shown	show	VBN
cord-001835-0s7ok4uw	1146	5	that	that	IN
cord-001835-0s7ok4uw	1146	6	proteins	protein	NNS
cord-001835-0s7ok4uw	1146	7	unfold	unfold	VBP
cord-001835-0s7ok4uw	1146	8	with	with	IN
cord-001835-0s7ok4uw	1146	9	different	different	JJ
cord-001835-0s7ok4uw	1146	10	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	1146	11	when	when	WRB
cord-001835-0s7ok4uw	1146	12	pulled	pull	VBN
cord-001835-0s7ok4uw	1146	13	from	from	IN
cord-001835-0s7ok4uw	1146	14	one	one	CD
cord-001835-0s7ok4uw	1146	15	terminus	terminus	NN
cord-001835-0s7ok4uw	1146	16	or	or	CC
cord-001835-0s7ok4uw	1146	17	the	the	DT
cord-001835-0s7ok4uw	1146	18	other4	other4	NN
cord-001835-0s7ok4uw	1146	19	.	.	.
cord-001835-0s7ok4uw	1147	1	Remarkably	remarkably	RB
cord-001835-0s7ok4uw	1147	2	,	,	,
cord-001835-0s7ok4uw	1147	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	1147	4	is	be	VBZ
cord-001835-0s7ok4uw	1147	5	also	also	RB
cord-001835-0s7ok4uw	1147	6	possible	possible	JJ
cord-001835-0s7ok4uw	1147	7	to	to	TO
cord-001835-0s7ok4uw	1147	8	say	say	VB
cord-001835-0s7ok4uw	1147	9	whether	whether	IN
cord-001835-0s7ok4uw	1147	10	the	the	DT
cord-001835-0s7ok4uw	1147	11	protein	protein	NN
cord-001835-0s7ok4uw	1147	12	has	have	VBZ
cord-001835-0s7ok4uw	1147	13	been	be	VBN
cord-001835-0s7ok4uw	1147	14	phosphorylated	phosphorylate	VBN
cord-001835-0s7ok4uw	1147	15	or	or	CC
cord-001835-0s7ok4uw	1147	16	not	not	RB
cord-001835-0s7ok4uw	1147	17	,	,	,
cord-001835-0s7ok4uw	1147	18	and	and	CC
cord-001835-0s7ok4uw	1147	19	where5	where5	NN
cord-001835-0s7ok4uw	1147	20	.	.	.
cord-001835-0s7ok4uw	1148	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1148	2	have	have	VBP
cord-001835-0s7ok4uw	1148	3	recently	recently	RB
cord-001835-0s7ok4uw	1148	4	advanced	advance	VBN
cord-001835-0s7ok4uw	1148	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1148	6	model	model	NN
cord-001835-0s7ok4uw	1148	7	system	system	NN
cord-001835-0s7ok4uw	1148	8	to	to	TO
cord-001835-0s7ok4uw	1148	9	study	study	VB
cord-001835-0s7ok4uw	1148	10	protein	protein	NN
cord-001835-0s7ok4uw	1148	11	folding	folding	NN
cord-001835-0s7ok4uw	1148	12	after	after	IN
cord-001835-0s7ok4uw	1148	13	translocation	translocation	NN
cord-001835-0s7ok4uw	1148	14	at	at	IN
cord-001835-0s7ok4uw	1148	15	the	the	DT
cord-001835-0s7ok4uw	1148	16	singlemolecule	singlemolecule	NNP
cord-001835-0s7ok4uw	1148	17	level6	level6	NNP
cord-001835-0s7ok4uw	1148	18	.	.	.
cord-001835-0s7ok4uw	1149	1	A	a	DT
cord-001835-0s7ok4uw	1149	2	single	single	JJ
cord-001835-0s7ok4uw	1149	3	-	-	HYPH
cord-001835-0s7ok4uw	1149	4	protein	protein	NN
cord-001835-0s7ok4uw	1149	5	molecule	molecule	NN
cord-001835-0s7ok4uw	1149	6	was	be	VBD
cord-001835-0s7ok4uw	1149	7	translocated	translocate	VBN
cord-001835-0s7ok4uw	1149	8	through	through	IN
cord-001835-0s7ok4uw	1149	9	a	a	DT
cord-001835-0s7ok4uw	1149	10	pore	pore	NN
cord-001835-0s7ok4uw	1149	11	and	and	CC
cord-001835-0s7ok4uw	1149	12	forced	force	VBD
cord-001835-0s7ok4uw	1149	13	to	to	TO
cord-001835-0s7ok4uw	1149	14	translocate	translocate	VB
cord-001835-0s7ok4uw	1149	15	back	back	RB
cord-001835-0s7ok4uw	1149	16	at	at	IN
cord-001835-0s7ok4uw	1149	17	predetermined	predetermined	JJ
cord-001835-0s7ok4uw	1149	18	times	time	NNS
cord-001835-0s7ok4uw	1149	19	.	.	.
cord-001835-0s7ok4uw	1150	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1150	2	measured	measure	VBD
cord-001835-0s7ok4uw	1150	3	the	the	DT
cord-001835-0s7ok4uw	1150	4	stability	stability	NN
cord-001835-0s7ok4uw	1150	5	of	of	IN
cord-001835-0s7ok4uw	1150	6	the	the	DT
cord-001835-0s7ok4uw	1150	7	refolded	refolde	VBN
cord-001835-0s7ok4uw	1150	8	state	state	NN
cord-001835-0s7ok4uw	1150	9	at	at	IN
cord-001835-0s7ok4uw	1150	10	different	different	JJ
cord-001835-0s7ok4uw	1150	11	times	time	NNS
cord-001835-0s7ok4uw	1150	12	and	and	CC
cord-001835-0s7ok4uw	1150	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	1150	14	obtained	obtain	VBD
cord-001835-0s7ok4uw	1150	15	the	the	DT
cord-001835-0s7ok4uw	1150	16	vectorial	vectorial	JJ
cord-001835-0s7ok4uw	1150	17	folding	folding	NN
cord-001835-0s7ok4uw	1150	18	pathway	pathway	NN
cord-001835-0s7ok4uw	1150	19	of	of	IN
cord-001835-0s7ok4uw	1150	20	the	the	DT
cord-001835-0s7ok4uw	1150	21	protein	protein	NN
cord-001835-0s7ok4uw	1150	22	.	.	.
cord-001835-0s7ok4uw	1151	1	Further	further	RB
cord-001835-0s7ok4uw	1151	2	,	,	,
cord-001835-0s7ok4uw	1151	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1151	4	observed	observe	VBD
cord-001835-0s7ok4uw	1151	5	that	that	IN
cord-001835-0s7ok4uw	1151	6	the	the	DT
cord-001835-0s7ok4uw	1151	7	protein	protein	NN
cord-001835-0s7ok4uw	1151	8	was	be	VBD
cord-001835-0s7ok4uw	1151	9	capable	capable	JJ
cord-001835-0s7ok4uw	1151	10	of	of	IN
cord-001835-0s7ok4uw	1151	11	co	co	JJ
cord-001835-0s7ok4uw	1151	12	-	-	JJ
cord-001835-0s7ok4uw	1151	13	translocational	translocational	JJ
cord-001835-0s7ok4uw	1151	14	folding	folding	NN
cord-001835-0s7ok4uw	1151	15	and	and	CC
cord-001835-0s7ok4uw	1151	16	that	that	IN
cord-001835-0s7ok4uw	1151	17	this	this	DT
cord-001835-0s7ok4uw	1151	18	premature	premature	JJ
cord-001835-0s7ok4uw	1151	19	folding	folding	NN
cord-001835-0s7ok4uw	1151	20	contributed	contribute	VBD
cord-001835-0s7ok4uw	1151	21	to	to	IN
cord-001835-0s7ok4uw	1151	22	the	the	DT
cord-001835-0s7ok4uw	1151	23	complete	complete	JJ
cord-001835-0s7ok4uw	1151	24	translocation	translocation	NN
cord-001835-0s7ok4uw	1151	25	of	of	IN
cord-001835-0s7ok4uw	1151	26	the	the	DT
cord-001835-0s7ok4uw	1151	27	protein	protein	NN
cord-001835-0s7ok4uw	1151	28	.	.	.
cord-001835-0s7ok4uw	1152	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1152	2	results	result	NNS
cord-001835-0s7ok4uw	1152	3	show	show	VBP
cord-001835-0s7ok4uw	1152	4	that	that	IN
cord-001835-0s7ok4uw	1152	5	nanopore	nanopore	NNP
cord-001835-0s7ok4uw	1152	6	technology	technology	NN
cord-001835-0s7ok4uw	1152	7	applied	apply	VBN
cord-001835-0s7ok4uw	1152	8	to	to	IN
cord-001835-0s7ok4uw	1152	9	proteins	protein	NNS
cord-001835-0s7ok4uw	1152	10	can	can	MD
cord-001835-0s7ok4uw	1152	11	be	be	VB
cord-001835-0s7ok4uw	1152	12	used	use	VBN
cord-001835-0s7ok4uw	1152	13	to	to	TO
cord-001835-0s7ok4uw	1152	14	describe	describe	VB
cord-001835-0s7ok4uw	1152	15	the	the	DT
cord-001835-0s7ok4uw	1152	16	vectorial	vectorial	JJ
cord-001835-0s7ok4uw	1152	17	folding	folding	NN
cord-001835-0s7ok4uw	1152	18	and	and	CC
cord-001835-0s7ok4uw	1152	19	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1152	20	of	of	IN
cord-001835-0s7ok4uw	1152	21	proteins	protein	NNS
cord-001835-0s7ok4uw	1152	22	,	,	,
cord-001835-0s7ok4uw	1152	23	providing	provide	VBG
cord-001835-0s7ok4uw	1152	24	insight	insight	NN
cord-001835-0s7ok4uw	1152	25	to	to	IN
cord-001835-0s7ok4uw	1152	26	how	how	WRB
cord-001835-0s7ok4uw	1152	27	these	these	DT
cord-001835-0s7ok4uw	1152	28	processes	process	NNS
cord-001835-0s7ok4uw	1152	29	may	may	MD
cord-001835-0s7ok4uw	1152	30	work	work	VB
cord-001835-0s7ok4uw	1152	31	in	in	IN
cord-001835-0s7ok4uw	1152	32	vivo	vivo	NN
cord-001835-0s7ok4uw	1152	33	.	.	.
cord-001835-0s7ok4uw	1153	1	Further	further	RB
cord-001835-0s7ok4uw	1153	2	,	,	,
cord-001835-0s7ok4uw	1153	3	single	single	JJ
cord-001835-0s7ok4uw	1153	4	-	-	HYPH
cord-001835-0s7ok4uw	1153	5	molecule	molecule	NN
cord-001835-0s7ok4uw	1153	6	protein	protein	NN
cord-001835-0s7ok4uw	1153	7	sequencing	sequencing	NN
cord-001835-0s7ok4uw	1153	8	is	be	VBZ
cord-001835-0s7ok4uw	1153	9	a	a	DT
cord-001835-0s7ok4uw	1153	10	possibility	possibility	NN
cord-001835-0s7ok4uw	1153	11	that	that	WDT
cord-001835-0s7ok4uw	1153	12	could	could	MD
cord-001835-0s7ok4uw	1153	13	revolutionise	revolutionise	VB
cord-001835-0s7ok4uw	1153	14	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1153	15	knowledge	knowledge	NN
cord-001835-0s7ok4uw	1153	16	on	on	IN
cord-001835-0s7ok4uw	1153	17	biological	biological	JJ
cord-001835-0s7ok4uw	1153	18	processes	process	NNS
cord-001835-0s7ok4uw	1153	19	.	.	.
cord-001835-0s7ok4uw	1154	1	Thermodynamics	thermodynamic	NNS
cord-001835-0s7ok4uw	1154	2	studies	study	NNS
cord-001835-0s7ok4uw	1154	3	of	of	IN
cord-001835-0s7ok4uw	1154	4	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	1154	5	proteins	protein	NNS
cord-001835-0s7ok4uw	1154	6	,	,	,
cord-001835-0s7ok4uw	1154	7	which	which	WDT
cord-001835-0s7ok4uw	1154	8	are	be	VBP
cord-001835-0s7ok4uw	1154	9	the	the	DT
cord-001835-0s7ok4uw	1154	10	dominant	dominant	JJ
cord-001835-0s7ok4uw	1154	11	protein	protein	NN
cord-001835-0s7ok4uw	1154	12	natural	natural	JJ
cord-001835-0s7ok4uw	1154	13	form	form	NN
cord-001835-0s7ok4uw	1154	14	,	,	,
cord-001835-0s7ok4uw	1154	15	have	have	VBP
cord-001835-0s7ok4uw	1154	16	been	be	VBN
cord-001835-0s7ok4uw	1154	17	often	often	RB
cord-001835-0s7ok4uw	1154	18	hampered	hamper	VBN
cord-001835-0s7ok4uw	1154	19	because	because	IN
cord-001835-0s7ok4uw	1154	20	irreversible	irreversible	JJ
cord-001835-0s7ok4uw	1154	21	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1154	22	and/or	and/or	CC
cord-001835-0s7ok4uw	1154	23	slow	slow	JJ
cord-001835-0s7ok4uw	1154	24	reactions	reaction	NNS
cord-001835-0s7ok4uw	1154	25	are	be	VBP
cord-001835-0s7ok4uw	1154	26	common	common	JJ
cord-001835-0s7ok4uw	1154	27	.	.	.
cord-001835-0s7ok4uw	1155	1	There	there	EX
cord-001835-0s7ok4uw	1155	2	is	be	VBZ
cord-001835-0s7ok4uw	1155	3	not	not	RB
cord-001835-0s7ok4uw	1155	4	a	a	DT
cord-001835-0s7ok4uw	1155	5	single	single	JJ
cord-001835-0s7ok4uw	1155	6	report	report	NN
cord-001835-0s7ok4uw	1155	7	on	on	IN
cord-001835-0s7ok4uw	1155	8	the	the	DT
cord-001835-0s7ok4uw	1155	9	reversible	reversible	JJ
cord-001835-0s7ok4uw	1155	10	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	1155	11	thermal	thermal	JJ
cord-001835-0s7ok4uw	1155	12	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1155	13	of	of	IN
cord-001835-0s7ok4uw	1155	14	proteins	protein	NNS
cord-001835-0s7ok4uw	1155	15	composed	compose	VBN
cord-001835-0s7ok4uw	1155	16	by	by	IN
cord-001835-0s7ok4uw	1155	17	(	(	-LRB-
cord-001835-0s7ok4uw	1155	18	b	b	NN
cord-001835-0s7ok4uw	1155	19	/	/	SYM
cord-001835-0s7ok4uw	1155	20	a)8	a)8	NN
cord-001835-0s7ok4uw	1155	21	barrel	barrel	NN
cord-001835-0s7ok4uw	1155	22	subunits	subunit	NNS
cord-001835-0s7ok4uw	1155	23	,	,	,
cord-001835-0s7ok4uw	1155	24	albeit	albeit	IN
cord-001835-0s7ok4uw	1155	25	this	this	DT
cord-001835-0s7ok4uw	1155	26	"	"	``
cord-001835-0s7ok4uw	1155	27	TIM	TIM	NNP
cord-001835-0s7ok4uw	1155	28	barrel	barrel	NN
cord-001835-0s7ok4uw	1155	29	"	"	''
cord-001835-0s7ok4uw	1155	30	topology	topology	NN
cord-001835-0s7ok4uw	1155	31	is	be	VBZ
cord-001835-0s7ok4uw	1155	32	one	one	CD
cord-001835-0s7ok4uw	1155	33	of	of	IN
cord-001835-0s7ok4uw	1155	34	the	the	DT
cord-001835-0s7ok4uw	1155	35	most	most	RBS
cord-001835-0s7ok4uw	1155	36	abundant	abundant	JJ
cord-001835-0s7ok4uw	1155	37	and	and	CC
cord-001835-0s7ok4uw	1155	38	versatile	versatile	JJ
cord-001835-0s7ok4uw	1155	39	in	in	IN
cord-001835-0s7ok4uw	1155	40	nature	nature	NN
cord-001835-0s7ok4uw	1155	41	.	.	.
cord-001835-0s7ok4uw	1156	1	The	the	DT
cord-001835-0s7ok4uw	1156	2	eponymous	eponymous	JJ
cord-001835-0s7ok4uw	1156	3	TIM	TIM	NNP
cord-001835-0s7ok4uw	1156	4	barrel	barrel	NN
cord-001835-0s7ok4uw	1156	5	,	,	,
cord-001835-0s7ok4uw	1156	6	Triosephosphate	Triosephosphate	NNP
cord-001835-0s7ok4uw	1156	7	isomerase	isomerase	NN
cord-001835-0s7ok4uw	1156	8	(	(	-LRB-
cord-001835-0s7ok4uw	1156	9	TIM	TIM	NNP
cord-001835-0s7ok4uw	1156	10	)	)	-RRB-
cord-001835-0s7ok4uw	1156	11	is	be	VBZ
cord-001835-0s7ok4uw	1156	12	a	a	DT
cord-001835-0s7ok4uw	1156	13	ubiquitous	ubiquitous	JJ
cord-001835-0s7ok4uw	1156	14	glycolytic	glycolytic	JJ
cord-001835-0s7ok4uw	1156	15	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1156	16	that	that	WDT
cord-001835-0s7ok4uw	1156	17	catalyzes	catalyze	VBZ
cord-001835-0s7ok4uw	1156	18	the	the	DT
cord-001835-0s7ok4uw	1156	19	isomerization	isomerization	NN
cord-001835-0s7ok4uw	1156	20	of	of	IN
cord-001835-0s7ok4uw	1156	21	glyceraldehyde-3-phosphate	glyceraldehyde-3-phosphate	NNP
cord-001835-0s7ok4uw	1156	22	and	and	CC
cord-001835-0s7ok4uw	1156	23	dihydroxyacetone	dihydroxyacetone	NN
cord-001835-0s7ok4uw	1156	24	phosphate	phosphate	NN
cord-001835-0s7ok4uw	1156	25	.	.	.
cord-001835-0s7ok4uw	1157	1	The	the	DT
cord-001835-0s7ok4uw	1157	2	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1157	3	of	of	IN
cord-001835-0s7ok4uw	1157	4	several	several	JJ
cord-001835-0s7ok4uw	1157	5	TIMs	tim	NNS
cord-001835-0s7ok4uw	1157	6	,	,	,
cord-001835-0s7ok4uw	1157	7	mainly	mainly	RB
cord-001835-0s7ok4uw	1157	8	of	of	IN
cord-001835-0s7ok4uw	1157	9	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	1157	10	organisms	organism	NNS
cord-001835-0s7ok4uw	1157	11	,	,	,
cord-001835-0s7ok4uw	1157	12	has	have	VBZ
cord-001835-0s7ok4uw	1157	13	been	be	VBN
cord-001835-0s7ok4uw	1157	14	extensively	extensively	RB
cord-001835-0s7ok4uw	1157	15	studied	study	VBN
cord-001835-0s7ok4uw	1157	16	.	.	.
cord-001835-0s7ok4uw	1158	1	Regarding	regard	VBG
cord-001835-0s7ok4uw	1158	2	thermal	thermal	JJ
cord-001835-0s7ok4uw	1158	3	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1158	4	,	,	,
cord-001835-0s7ok4uw	1158	5	eighteen	eighteen	CD
cord-001835-0s7ok4uw	1158	6	TIMs	tim	NNS
cord-001835-0s7ok4uw	1158	7	,	,	,
cord-001835-0s7ok4uw	1158	8	mainly	mainly	RB
cord-001835-0s7ok4uw	1158	9	from	from	IN
cord-001835-0s7ok4uw	1158	10	eukaryotes	eukaryote	NNS
cord-001835-0s7ok4uw	1158	11	,	,	,
cord-001835-0s7ok4uw	1158	12	as	as	RB
cord-001835-0s7ok4uw	1158	13	diverse	diverse	JJ
cord-001835-0s7ok4uw	1158	14	as	as	IN
cord-001835-0s7ok4uw	1158	15	Amoebozoa	Amoebozoa	NNP
cord-001835-0s7ok4uw	1158	16	,	,	,
cord-001835-0s7ok4uw	1158	17	Euglenozoa	Euglenozoa	NNP
cord-001835-0s7ok4uw	1158	18	,	,	,
cord-001835-0s7ok4uw	1158	19	Ascomycota	Ascomycota	NNP
cord-001835-0s7ok4uw	1158	20	and	and	CC
cord-001835-0s7ok4uw	1158	21	Chordata	Chordata	NNP
cord-001835-0s7ok4uw	1158	22	,	,	,
cord-001835-0s7ok4uw	1158	23	have	have	VBP
cord-001835-0s7ok4uw	1158	24	been	be	VBN
cord-001835-0s7ok4uw	1158	25	studied	study	VBN
cord-001835-0s7ok4uw	1158	26	.	.	.
cord-001835-0s7ok4uw	1159	1	Even	even	RB
cord-001835-0s7ok4uw	1159	2	though	though	IN
cord-001835-0s7ok4uw	1159	3	a	a	DT
cord-001835-0s7ok4uw	1159	4	full	full	JJ
cord-001835-0s7ok4uw	1159	5	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1159	6	characterization	characterization	NN
cord-001835-0s7ok4uw	1159	7	has	have	VBZ
cord-001835-0s7ok4uw	1159	8	been	be	VBN
cord-001835-0s7ok4uw	1159	9	hampered	hamper	VBN
cord-001835-0s7ok4uw	1159	10	by	by	IN
cord-001835-0s7ok4uw	1159	11	irreversible	irreversible	JJ
cord-001835-0s7ok4uw	1159	12	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1159	13	and/or	and/or	CC
cord-001835-0s7ok4uw	1159	14	the	the	DT
cord-001835-0s7ok4uw	1159	15	presence	presence	NN
cord-001835-0s7ok4uw	1159	16	of	of	IN
cord-001835-0s7ok4uw	1159	17	hysteresis	hysteresis	NN
cord-001835-0s7ok4uw	1159	18	in	in	IN
cord-001835-0s7ok4uw	1159	19	all	all	DT
cord-001835-0s7ok4uw	1159	20	of	of	IN
cord-001835-0s7ok4uw	1159	21	them	-PRON-	PRP
cord-001835-0s7ok4uw	1159	22	,	,	,
cord-001835-0s7ok4uw	1159	23	the	the	DT
cord-001835-0s7ok4uw	1159	24	activation	activation	NN
cord-001835-0s7ok4uw	1159	25	parameters	parameter	NNS
cord-001835-0s7ok4uw	1159	26	that	that	WDT
cord-001835-0s7ok4uw	1159	27	describe	describe	VBP
cord-001835-0s7ok4uw	1159	28	the	the	DT
cord-001835-0s7ok4uw	1159	29	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1159	30	control	control	NN
cord-001835-0s7ok4uw	1159	31	of	of	IN
cord-001835-0s7ok4uw	1159	32	five	five	CD
cord-001835-0s7ok4uw	1159	33	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	1159	34	TIMs	TIMs	NNPS
cord-001835-0s7ok4uw	1159	35	have	have	VBP
cord-001835-0s7ok4uw	1159	36	been	be	VBN
cord-001835-0s7ok4uw	1159	37	reported	report	VBN
cord-001835-0s7ok4uw	1159	38	.	.	.
cord-001835-0s7ok4uw	1160	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1160	2	characterized	characterize	VBD
cord-001835-0s7ok4uw	1160	3	the	the	DT
cord-001835-0s7ok4uw	1160	4	structure	structure	NN
cord-001835-0s7ok4uw	1160	5	,	,	,
cord-001835-0s7ok4uw	1160	6	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1160	7	properties	property	NNS
cord-001835-0s7ok4uw	1160	8	,	,	,
cord-001835-0s7ok4uw	1160	9	association	association	NN
cord-001835-0s7ok4uw	1160	10	state	state	NN
cord-001835-0s7ok4uw	1160	11	and	and	CC
cord-001835-0s7ok4uw	1160	12	temperature	temperature	NN
cord-001835-0s7ok4uw	1160	13	-	-	HYPH
cord-001835-0s7ok4uw	1160	14	induced	induce	VBN
cord-001835-0s7ok4uw	1160	15	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1160	16	of	of	IN
cord-001835-0s7ok4uw	1160	17	the	the	DT
cord-001835-0s7ok4uw	1160	18	eponymous	eponymous	JJ
cord-001835-0s7ok4uw	1160	19	TIM	TIM	NNP
cord-001835-0s7ok4uw	1160	20	barrel	barrel	NN
cord-001835-0s7ok4uw	1160	21	,	,	,
cord-001835-0s7ok4uw	1160	22	Triosephosphate	Triosephosphate	NNP
cord-001835-0s7ok4uw	1160	23	Isomerase	Isomerase	NNP
cord-001835-0s7ok4uw	1160	24	(	(	-LRB-
cord-001835-0s7ok4uw	1160	25	TIM	TIM	NNP
cord-001835-0s7ok4uw	1160	26	)	)	-RRB-
cord-001835-0s7ok4uw	1160	27	,	,	,
cord-001835-0s7ok4uw	1160	28	belonging	belong	VBG
cord-001835-0s7ok4uw	1160	29	to	to	IN
cord-001835-0s7ok4uw	1160	30	five	five	CD
cord-001835-0s7ok4uw	1160	31	species	specie	NNS
cord-001835-0s7ok4uw	1160	32	representative	representative	NN
cord-001835-0s7ok4uw	1160	33	of	of	IN
cord-001835-0s7ok4uw	1160	34	different	different	JJ
cord-001835-0s7ok4uw	1160	35	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	1160	36	taxa	taxon	NNS
cord-001835-0s7ok4uw	1160	37	:	:	:
cord-001835-0s7ok4uw	1160	38	Deinococcus	Deinococcus	NNP
cord-001835-0s7ok4uw	1160	39	radiodurans	radioduran	NNS
cord-001835-0s7ok4uw	1160	40	(	(	-LRB-
cord-001835-0s7ok4uw	1160	41	DrTIM	DrTIM	NNP
cord-001835-0s7ok4uw	1160	42	)	)	-RRB-
cord-001835-0s7ok4uw	1160	43	,	,	,
cord-001835-0s7ok4uw	1160	44	Nostoc	Nostoc	NNP
cord-001835-0s7ok4uw	1160	45	punctiforme	punctiforme	NNP
cord-001835-0s7ok4uw	1160	46	(	(	-LRB-
cord-001835-0s7ok4uw	1160	47	NpTIM	NpTIM	NNP
cord-001835-0s7ok4uw	1160	48	)	)	-RRB-
cord-001835-0s7ok4uw	1160	49	,	,	,
cord-001835-0s7ok4uw	1160	50	Gemmata	Gemmata	NNP
cord-001835-0s7ok4uw	1160	51	obscuriglobus	obscuriglobus	NN
cord-001835-0s7ok4uw	1160	52	(	(	-LRB-
cord-001835-0s7ok4uw	1160	53	GoTIM	GoTIM	NNP
cord-001835-0s7ok4uw	1160	54	)	)	-RRB-
cord-001835-0s7ok4uw	1160	55	,	,	,
cord-001835-0s7ok4uw	1160	56	Clostridium	clostridium	NN
cord-001835-0s7ok4uw	1160	57	perfringens	perfringen	NNS
cord-001835-0s7ok4uw	1160	58	(	(	-LRB-
cord-001835-0s7ok4uw	1160	59	CpTIM	CpTIM	NNP
cord-001835-0s7ok4uw	1160	60	)	)	-RRB-
cord-001835-0s7ok4uw	1160	61	and	and	CC
cord-001835-0s7ok4uw	1160	62	Streptomyces	Streptomyces	NNP
cord-001835-0s7ok4uw	1160	63	coelicolor	coelicolor	NNP
cord-001835-0s7ok4uw	1160	64	(	(	-LRB-
cord-001835-0s7ok4uw	1160	65	ScTIM	ScTIM	NNP
cord-001835-0s7ok4uw	1160	66	)	)	-RRB-
cord-001835-0s7ok4uw	1160	67	.	.	.
cord-001835-0s7ok4uw	1161	1	Irreversibility	irreversibility	NN
cord-001835-0s7ok4uw	1161	2	and	and	CC
cord-001835-0s7ok4uw	1161	3	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1161	4	control	control	NN
cord-001835-0s7ok4uw	1161	5	were	be	VBD
cord-001835-0s7ok4uw	1161	6	observed	observe	VBN
cord-001835-0s7ok4uw	1161	7	in	in	IN
cord-001835-0s7ok4uw	1161	8	the	the	DT
cord-001835-0s7ok4uw	1161	9	thermal	thermal	JJ
cord-001835-0s7ok4uw	1161	10	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1161	11	of	of	IN
cord-001835-0s7ok4uw	1161	12	NpTIM	NpTIM	NNP
cord-001835-0s7ok4uw	1161	13	and	and	CC
cord-001835-0s7ok4uw	1161	14	GoTIM	GoTIM	NNP
cord-001835-0s7ok4uw	1161	15	,	,	,
cord-001835-0s7ok4uw	1161	16	while	while	IN
cord-001835-0s7ok4uw	1161	17	for	for	IN
cord-001835-0s7ok4uw	1161	18	DrTIM	DrTIM	NNP
cord-001835-0s7ok4uw	1161	19	,	,	,
cord-001835-0s7ok4uw	1161	20	ScTIM	ScTIM	NNP
cord-001835-0s7ok4uw	1161	21	and	and	CC
cord-001835-0s7ok4uw	1161	22	CpTIM	CpTIM	NNP
cord-001835-0s7ok4uw	1161	23	,	,	,
cord-001835-0s7ok4uw	1161	24	the	the	DT
cord-001835-0s7ok4uw	1161	25	thermal	thermal	JJ
cord-001835-0s7ok4uw	1161	26	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1161	27	was	be	VBD
cord-001835-0s7ok4uw	1161	28	found	find	VBN
cord-001835-0s7ok4uw	1161	29	to	to	TO
cord-001835-0s7ok4uw	1161	30	follow	follow	VB
cord-001835-0s7ok4uw	1161	31	a	a	DT
cord-001835-0s7ok4uw	1161	32	two	two	CD
cord-001835-0s7ok4uw	1161	33	-	-	HYPH
cord-001835-0s7ok4uw	1161	34	state	state	NN
cord-001835-0s7ok4uw	1161	35	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	1161	36	reversible	reversible	JJ
cord-001835-0s7ok4uw	1161	37	process	process	NN
cord-001835-0s7ok4uw	1161	38	,	,	,
cord-001835-0s7ok4uw	1161	39	a	a	DT
cord-001835-0s7ok4uw	1161	40	behavior	behavior	NN
cord-001835-0s7ok4uw	1161	41	not	not	RB
cord-001835-0s7ok4uw	1161	42	observed	observe	VBD
cord-001835-0s7ok4uw	1161	43	previously	previously	RB
cord-001835-0s7ok4uw	1161	44	for	for	IN
cord-001835-0s7ok4uw	1161	45	others	other	NNS
cord-001835-0s7ok4uw	1161	46	TIMs	TIMs	NNP
cord-001835-0s7ok4uw	1161	47	.	.	.
cord-001835-0s7ok4uw	1162	1	Shifts	shift	NNS
cord-001835-0s7ok4uw	1162	2	in	in	IN
cord-001835-0s7ok4uw	1162	3	the	the	DT
cord-001835-0s7ok4uw	1162	4	global	global	JJ
cord-001835-0s7ok4uw	1162	5	stability	stability	NN
cord-001835-0s7ok4uw	1162	6	curves	curve	NNS
cord-001835-0s7ok4uw	1162	7	of	of	IN
cord-001835-0s7ok4uw	1162	8	these	these	DT
cord-001835-0s7ok4uw	1162	9	three	three	CD
cord-001835-0s7ok4uw	1162	10	proteins	protein	NNS
cord-001835-0s7ok4uw	1162	11	are	be	VBP
cord-001835-0s7ok4uw	1162	12	related	relate	VBN
cord-001835-0s7ok4uw	1162	13	to	to	IN
cord-001835-0s7ok4uw	1162	14	organismal	organismal	JJ
cord-001835-0s7ok4uw	1162	15	temperature	temperature	NN
cord-001835-0s7ok4uw	1162	16	range	range	NN
cord-001835-0s7ok4uw	1162	17	of	of	IN
cord-001835-0s7ok4uw	1162	18	optimal	optimal	JJ
cord-001835-0s7ok4uw	1162	19	growth	growth	NN
cord-001835-0s7ok4uw	1162	20	and	and	CC
cord-001835-0s7ok4uw	1162	21	modulated	modulate	VBN
cord-001835-0s7ok4uw	1162	22	by	by	IN
cord-001835-0s7ok4uw	1162	23	variations	variation	NNS
cord-001835-0s7ok4uw	1162	24	in	in	IN
cord-001835-0s7ok4uw	1162	25	maximum	maximum	JJ
cord-001835-0s7ok4uw	1162	26	stability	stability	NN
cord-001835-0s7ok4uw	1162	27	temperature	temperature	NN
cord-001835-0s7ok4uw	1162	28	and	and	CC
cord-001835-0s7ok4uw	1162	29	in	in	IN
cord-001835-0s7ok4uw	1162	30	the	the	DT
cord-001835-0s7ok4uw	1162	31	enthalpy	enthalpy	NN
cord-001835-0s7ok4uw	1162	32	change	change	NN
cord-001835-0s7ok4uw	1162	33	at	at	IN
cord-001835-0s7ok4uw	1162	34	that	that	DT
cord-001835-0s7ok4uw	1162	35	temperature	temperature	NN
cord-001835-0s7ok4uw	1162	36	.	.	.
cord-001835-0s7ok4uw	1163	1	Reversibility	Reversibility	NNP
cord-001835-0s7ok4uw	1163	2	appears	appear	VBZ
cord-001835-0s7ok4uw	1163	3	to	to	TO
cord-001835-0s7ok4uw	1163	4	correlate	correlate	VB
cord-001835-0s7ok4uw	1163	5	with	with	IN
cord-001835-0s7ok4uw	1163	6	low	low	JJ
cord-001835-0s7ok4uw	1163	7	isoelectric	isoelectric	JJ
cord-001835-0s7ok4uw	1163	8	point	point	NN
cord-001835-0s7ok4uw	1163	9	,	,	,
cord-001835-0s7ok4uw	1163	10	the	the	DT
cord-001835-0s7ok4uw	1163	11	absence	absence	NN
cord-001835-0s7ok4uw	1163	12	of	of	IN
cord-001835-0s7ok4uw	1163	13	residual	residual	JJ
cord-001835-0s7ok4uw	1163	14	structure	structure	NN
cord-001835-0s7ok4uw	1163	15	in	in	IN
cord-001835-0s7ok4uw	1163	16	the	the	DT
cord-001835-0s7ok4uw	1163	17	unfolded	unfold	VBN
cord-001835-0s7ok4uw	1163	18	state	state	NN
cord-001835-0s7ok4uw	1163	19	,	,	,
cord-001835-0s7ok4uw	1163	20	small	small	JJ
cord-001835-0s7ok4uw	1163	21	cavity	cavity	NN
cord-001835-0s7ok4uw	1163	22	volume	volume	NN
cord-001835-0s7ok4uw	1163	23	in	in	IN
cord-001835-0s7ok4uw	1163	24	the	the	DT
cord-001835-0s7ok4uw	1163	25	native	native	JJ
cord-001835-0s7ok4uw	1163	26	state	state	NN
cord-001835-0s7ok4uw	1163	27	structure	structure	NN
cord-001835-0s7ok4uw	1163	28	,	,	,
cord-001835-0s7ok4uw	1163	29	low	low	JJ
cord-001835-0s7ok4uw	1163	30	conformational	conformational	JJ
cord-001835-0s7ok4uw	1163	31	stability	stability	NN
cord-001835-0s7ok4uw	1163	32	and	and	CC
cord-001835-0s7ok4uw	1163	33	a	a	DT
cord-001835-0s7ok4uw	1163	34	low	low	JJ
cord-001835-0s7ok4uw	1163	35	melting	melting	NN
cord-001835-0s7ok4uw	1163	36	temperature	temperature	NN
cord-001835-0s7ok4uw	1163	37	.	.	.
cord-001835-0s7ok4uw	1164	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1164	2	,	,	,
cord-001835-0s7ok4uw	1164	3	the	the	DT
cord-001835-0s7ok4uw	1164	4	strong	strong	JJ
cord-001835-0s7ok4uw	1164	5	coupling	coupling	NN
cord-001835-0s7ok4uw	1164	6	between	between	IN
cord-001835-0s7ok4uw	1164	7	dimer	dimer	NN
cord-001835-0s7ok4uw	1164	8	dissociation	dissociation	NN
cord-001835-0s7ok4uw	1164	9	and	and	CC
cord-001835-0s7ok4uw	1164	10	monomer	monomer	NN
cord-001835-0s7ok4uw	1164	11	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1164	12	may	may	MD
cord-001835-0s7ok4uw	1164	13	reduce	reduce	VB
cord-001835-0s7ok4uw	1164	14	the	the	DT
cord-001835-0s7ok4uw	1164	15	possibility	possibility	NN
cord-001835-0s7ok4uw	1164	16	of	of	IN
cord-001835-0s7ok4uw	1164	17	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1164	18	and	and	CC
cord-001835-0s7ok4uw	1164	19	favor	favor	VBP
cord-001835-0s7ok4uw	1164	20	reversibility	reversibility	NN
cord-001835-0s7ok4uw	1164	21	.	.	.
cord-001835-0s7ok4uw	1165	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1165	2	appears	appear	VBZ
cord-001835-0s7ok4uw	1165	3	that	that	IN
cord-001835-0s7ok4uw	1165	4	there	there	EX
cord-001835-0s7ok4uw	1165	5	is	be	VBZ
cord-001835-0s7ok4uw	1165	6	a	a	DT
cord-001835-0s7ok4uw	1165	7	delicate	delicate	JJ
cord-001835-0s7ok4uw	1165	8	balance	balance	NN
cord-001835-0s7ok4uw	1165	9	between	between	IN
cord-001835-0s7ok4uw	1165	10	several	several	JJ
cord-001835-0s7ok4uw	1165	11	contributions	contribution	NNS
cord-001835-0s7ok4uw	1165	12	whose	whose	WP$
cord-001835-0s7ok4uw	1165	13	concerted	concerted	JJ
cord-001835-0s7ok4uw	1165	14	interplay	interplay	NN
cord-001835-0s7ok4uw	1165	15	is	be	VBZ
cord-001835-0s7ok4uw	1165	16	necessary	necessary	JJ
cord-001835-0s7ok4uw	1165	17	to	to	TO
cord-001835-0s7ok4uw	1165	18	achieve	achieve	VB
cord-001835-0s7ok4uw	1165	19	thermal	thermal	JJ
cord-001835-0s7ok4uw	1165	20	reversibility	reversibility	NN
cord-001835-0s7ok4uw	1165	21	in	in	IN
cord-001835-0s7ok4uw	1165	22	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	1165	23	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	1165	24	.	.	.
cord-001835-0s7ok4uw	1166	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1166	2	,	,	,
cord-001835-0s7ok4uw	1166	3	the	the	DT
cord-001835-0s7ok4uw	1166	4	finding	finding	NN
cord-001835-0s7ok4uw	1166	5	that	that	IN
cord-001835-0s7ok4uw	1166	6	the	the	DT
cord-001835-0s7ok4uw	1166	7	three	three	CD
cord-001835-0s7ok4uw	1166	8	reversible	reversible	JJ
cord-001835-0s7ok4uw	1166	9	proteins	protein	NNS
cord-001835-0s7ok4uw	1166	10	come	come	VBP
cord-001835-0s7ok4uw	1166	11	from	from	IN
cord-001835-0s7ok4uw	1166	12	organisms	organism	NNS
cord-001835-0s7ok4uw	1166	13	from	from	IN
cord-001835-0s7ok4uw	1166	14	different	different	JJ
cord-001835-0s7ok4uw	1166	15	phyla	phylum	NNS
cord-001835-0s7ok4uw	1166	16	suggests	suggest	VBZ
cord-001835-0s7ok4uw	1166	17	that	that	IN
cord-001835-0s7ok4uw	1166	18	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1166	19	reversibility	reversibility	NN
cord-001835-0s7ok4uw	1166	20	may	may	MD
cord-001835-0s7ok4uw	1166	21	be	be	VB
cord-001835-0s7ok4uw	1166	22	more	more	RBR
cord-001835-0s7ok4uw	1166	23	common	common	JJ
cord-001835-0s7ok4uw	1166	24	than	than	IN
cord-001835-0s7ok4uw	1166	25	what	what	WP
cord-001835-0s7ok4uw	1166	26	is	be	VBZ
cord-001835-0s7ok4uw	1166	27	currently	currently	RB
cord-001835-0s7ok4uw	1166	28	known	know	VBN
cord-001835-0s7ok4uw	1166	29	Supported	support	VBN
cord-001835-0s7ok4uw	1166	30	by	by	IN
cord-001835-0s7ok4uw	1166	31	 	 	_SP
cord-001835-0s7ok4uw	1166	32	A	a	DT
cord-001835-0s7ok4uw	1166	33	critical	critical	JJ
cord-001835-0s7ok4uw	1166	34	step	step	NN
cord-001835-0s7ok4uw	1166	35	in	in	IN
cord-001835-0s7ok4uw	1166	36	the	the	DT
cord-001835-0s7ok4uw	1166	37	late	late	JJ
cord-001835-0s7ok4uw	1166	38	phase	phase	NN
cord-001835-0s7ok4uw	1166	39	of	of	IN
cord-001835-0s7ok4uw	1166	40	human	human	JJ
cord-001835-0s7ok4uw	1166	41	immunodeficiency	immunodeficiency	NN
cord-001835-0s7ok4uw	1166	42	virus	virus	NN
cord-001835-0s7ok4uw	1166	43	type	type	NN
cord-001835-0s7ok4uw	1166	44	1	1	CD
cord-001835-0s7ok4uw	1166	45	(	(	-LRB-
cord-001835-0s7ok4uw	1166	46	HIV-1	HIV-1	NNP
cord-001835-0s7ok4uw	1166	47	)	)	-RRB-
cord-001835-0s7ok4uw	1166	48	infection	infection	NN
cord-001835-0s7ok4uw	1166	49	is	be	VBZ
cord-001835-0s7ok4uw	1166	50	targeting	target	VBG
cord-001835-0s7ok4uw	1166	51	of	of	IN
cord-001835-0s7ok4uw	1166	52	the	the	DT
cord-001835-0s7ok4uw	1166	53	virally	virally	RB
cord-001835-0s7ok4uw	1166	54	encoded	encode	VBN
cord-001835-0s7ok4uw	1166	55	Gag	Gag	NNP
cord-001835-0s7ok4uw	1166	56	proteins	protein	NNS
cord-001835-0s7ok4uw	1166	57	to	to	IN
cord-001835-0s7ok4uw	1166	58	the	the	DT
cord-001835-0s7ok4uw	1166	59	plasma	plasma	NN
cord-001835-0s7ok4uw	1166	60	membrane	membrane	NN
cord-001835-0s7ok4uw	1166	61	(	(	-LRB-
cord-001835-0s7ok4uw	1166	62	PM	PM	NNP
cord-001835-0s7ok4uw	1166	63	)	)	-RRB-
cord-001835-0s7ok4uw	1166	64	for	for	IN
cord-001835-0s7ok4uw	1166	65	assembly	assembly	NN
cord-001835-0s7ok4uw	1166	66	.	.	.
cord-001835-0s7ok4uw	1167	1	Prior	prior	RB
cord-001835-0s7ok4uw	1167	2	to	to	IN
cord-001835-0s7ok4uw	1167	3	assembly	assembly	NN
cord-001835-0s7ok4uw	1167	4	,	,	,
cord-001835-0s7ok4uw	1167	5	the	the	DT
cord-001835-0s7ok4uw	1167	6	HIV-1	HIV-1	NNP
cord-001835-0s7ok4uw	1167	7	Gag	Gag	NNP
cord-001835-0s7ok4uw	1167	8	polyprotein	polyprotein	NN
cord-001835-0s7ok4uw	1167	9	adopts	adopt	VBZ
cord-001835-0s7ok4uw	1167	10	a	a	DT
cord-001835-0s7ok4uw	1167	11	compact	compact	JJ
cord-001835-0s7ok4uw	1167	12	"	"	``
cord-001835-0s7ok4uw	1167	13	folded	fold	VBN
cord-001835-0s7ok4uw	1167	14	over	over	RP
cord-001835-0s7ok4uw	1167	15	"	"	``
cord-001835-0s7ok4uw	1167	16	conformation	conformation	NN
cord-001835-0s7ok4uw	1167	17	and	and	CC
cord-001835-0s7ok4uw	1167	18	exists	exist	VBZ
cord-001835-0s7ok4uw	1167	19	in	in	IN
cord-001835-0s7ok4uw	1167	20	the	the	DT
cord-001835-0s7ok4uw	1167	21	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	1167	22	or	or	CC
cord-001835-0s7ok4uw	1167	23	low	low	JJ
cord-001835-0s7ok4uw	1167	24	-	-	HYPH
cord-001835-0s7ok4uw	1167	25	order	order	NN
cord-001835-0s7ok4uw	1167	26	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	1167	27	states	state	NNS
cord-001835-0s7ok4uw	1167	28	.	.	.
cord-001835-0s7ok4uw	1168	1	Whereas	whereas	IN
cord-001835-0s7ok4uw	1168	2	it	-PRON-	PRP
cord-001835-0s7ok4uw	1168	3	is	be	VBZ
cord-001835-0s7ok4uw	1168	4	established	establish	VBN
cord-001835-0s7ok4uw	1168	5	that	that	IN
cord-001835-0s7ok4uw	1168	6	the	the	DT
cord-001835-0s7ok4uw	1168	7	nucleocapsid	nucleocapsid	NNP
cord-001835-0s7ok4uw	1168	8	domain	domain	NN
cord-001835-0s7ok4uw	1168	9	of	of	IN
cord-001835-0s7ok4uw	1168	10	Gag	Gag	NNP
cord-001835-0s7ok4uw	1168	11	specifically	specifically	RB
cord-001835-0s7ok4uw	1168	12	recognizes	recognize	VBZ
cord-001835-0s7ok4uw	1168	13	motifs	motif	NNS
cord-001835-0s7ok4uw	1168	14	in	in	IN
cord-001835-0s7ok4uw	1168	15	the	the	DT
cord-001835-0s7ok4uw	1168	16	viral	viral	JJ
cord-001835-0s7ok4uw	1168	17	RNA	RNA	NNP
cord-001835-0s7ok4uw	1168	18	genome	genome	NN
cord-001835-0s7ok4uw	1168	19	for	for	IN
cord-001835-0s7ok4uw	1168	20	packaging	packaging	NN
cord-001835-0s7ok4uw	1168	21	,	,	,
cord-001835-0s7ok4uw	1168	22	there	there	EX
cord-001835-0s7ok4uw	1168	23	is	be	VBZ
cord-001835-0s7ok4uw	1168	24	compelling	compelling	JJ
cord-001835-0s7ok4uw	1168	25	evidence	evidence	NN
cord-001835-0s7ok4uw	1168	26	that	that	IN
cord-001835-0s7ok4uw	1168	27	the	the	DT
cord-001835-0s7ok4uw	1168	28	myristoylated	myristoylated	JJ
cord-001835-0s7ok4uw	1168	29	matrix	matrix	NN
cord-001835-0s7ok4uw	1168	30	(	(	-LRB-
cord-001835-0s7ok4uw	1168	31	MA	MA	NNP
cord-001835-0s7ok4uw	1168	32	)	)	-RRB-
cord-001835-0s7ok4uw	1168	33	domain	domain	NN
cord-001835-0s7ok4uw	1168	34	also	also	RB
cord-001835-0s7ok4uw	1168	35	binds	bind	VBZ
cord-001835-0s7ok4uw	1168	36	to	to	IN
cord-001835-0s7ok4uw	1168	37	cellular	cellular	JJ
cord-001835-0s7ok4uw	1168	38	RNA	RNA	NNP
cord-001835-0s7ok4uw	1168	39	to	to	TO
cord-001835-0s7ok4uw	1168	40	prevent	prevent	VB
cord-001835-0s7ok4uw	1168	41	premature	premature	JJ
cord-001835-0s7ok4uw	1168	42	Gag	gag	NN
cord-001835-0s7ok4uw	1168	43	targeting	target	VBG
cord-001835-0s7ok4uw	1168	44	to	to	IN
cord-001835-0s7ok4uw	1168	45	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	1168	46	membranes	membrane	NNS
cord-001835-0s7ok4uw	1168	47	.	.	.
cord-001835-0s7ok4uw	1169	1	Upon	upon	IN
cord-001835-0s7ok4uw	1169	2	transport	transport	NN
cord-001835-0s7ok4uw	1169	3	of	of	IN
cord-001835-0s7ok4uw	1169	4	Gag	gag	NN
cord-001835-0s7ok4uw	1169	5	to	to	IN
cord-001835-0s7ok4uw	1169	6	the	the	DT
cord-001835-0s7ok4uw	1169	7	PM	pm	NN
cord-001835-0s7ok4uw	1169	8	,	,	,
cord-001835-0s7ok4uw	1169	9	the	the	DT
cord-001835-0s7ok4uw	1169	10	interaction	interaction	NN
cord-001835-0s7ok4uw	1169	11	of	of	IN
cord-001835-0s7ok4uw	1169	12	MA	MA	NNP
cord-001835-0s7ok4uw	1169	13	with	with	IN
cord-001835-0s7ok4uw	1169	14	RNA	RNA	NNP
cord-001835-0s7ok4uw	1169	15	is	be	VBZ
cord-001835-0s7ok4uw	1169	16	exchanged	exchange	VBN
cord-001835-0s7ok4uw	1169	17	for	for	IN
cord-001835-0s7ok4uw	1169	18	an	an	DT
cord-001835-0s7ok4uw	1169	19	interaction	interaction	NN
cord-001835-0s7ok4uw	1169	20	of	of	IN
cord-001835-0s7ok4uw	1169	21	MA	MA	NNP
cord-001835-0s7ok4uw	1169	22	with	with	IN
cord-001835-0s7ok4uw	1169	23	PM	PM	NNP
cord-001835-0s7ok4uw	1169	24	components	component	NNS
cord-001835-0s7ok4uw	1169	25	.	.	.
cord-001835-0s7ok4uw	1170	1	This	this	DT
cord-001835-0s7ok4uw	1170	2	molecular	molecular	JJ
cord-001835-0s7ok4uw	1170	3	switch	switch	NN
cord-001835-0s7ok4uw	1170	4	induces	induce	VBZ
cord-001835-0s7ok4uw	1170	5	an	an	DT
cord-001835-0s7ok4uw	1170	6	extended	extended	JJ
cord-001835-0s7ok4uw	1170	7	conformation	conformation	NN
cord-001835-0s7ok4uw	1170	8	of	of	IN
cord-001835-0s7ok4uw	1170	9	Gag	Gag	NNP
cord-001835-0s7ok4uw	1170	10	,	,	,
cord-001835-0s7ok4uw	1170	11	leading	lead	VBG
cord-001835-0s7ok4uw	1170	12	to	to	IN
cord-001835-0s7ok4uw	1170	13	formation	formation	NN
cord-001835-0s7ok4uw	1170	14	of	of	IN
cord-001835-0s7ok4uw	1170	15	high	high	JJ
cord-001835-0s7ok4uw	1170	16	-	-	HYPH
cord-001835-0s7ok4uw	1170	17	order	order	NN
cord-001835-0s7ok4uw	1170	18	Gag	Gag	NNP
cord-001835-0s7ok4uw	1170	19	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	1170	20	on	on	IN
cord-001835-0s7ok4uw	1170	21	the	the	DT
cord-001835-0s7ok4uw	1170	22	PM	pm	NN
cord-001835-0s7ok4uw	1170	23	.	.	.
cord-001835-0s7ok4uw	1171	1	Because	because	IN
cord-001835-0s7ok4uw	1171	2	Gag	Gag	NNP
cord-001835-0s7ok4uw	1171	3	is	be	VBZ
cord-001835-0s7ok4uw	1171	4	anchored	anchor	VBN
cord-001835-0s7ok4uw	1171	5	and	and	CC
cord-001835-0s7ok4uw	1171	6	therefore	therefore	RB
cord-001835-0s7ok4uw	1171	7	captured	capture	VBN
cord-001835-0s7ok4uw	1171	8	by	by	IN
cord-001835-0s7ok4uw	1171	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1171	10	interaction	interaction	NN
cord-001835-0s7ok4uw	1171	11	with	with	IN
cord-001835-0s7ok4uw	1171	12	the	the	DT
cord-001835-0s7ok4uw	1171	13	available	available	JJ
cord-001835-0s7ok4uw	1171	14	phospholipids	phospholipid	NNS
cord-001835-0s7ok4uw	1171	15	,	,	,
cord-001835-0s7ok4uw	1171	16	the	the	DT
cord-001835-0s7ok4uw	1171	17	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	1171	18	targeting	targeting	NN
cord-001835-0s7ok4uw	1171	19	of	of	IN
cord-001835-0s7ok4uw	1171	20	Gag	Gag	NNP
cord-001835-0s7ok4uw	1171	21	is	be	VBZ
cord-001835-0s7ok4uw	1171	22	likely	likely	JJ
cord-001835-0s7ok4uw	1171	23	to	to	TO
cord-001835-0s7ok4uw	1171	24	be	be	VB
cord-001835-0s7ok4uw	1171	25	determined	determine	VBN
cord-001835-0s7ok4uw	1171	26	by	by	IN
cord-001835-0s7ok4uw	1171	27	the	the	DT
cord-001835-0s7ok4uw	1171	28	relative	relative	JJ
cord-001835-0s7ok4uw	1171	29	strength	strength	NN
cord-001835-0s7ok4uw	1171	30	of	of	IN
cord-001835-0s7ok4uw	1171	31	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1171	32	interaction	interaction	NN
cord-001835-0s7ok4uw	1171	33	with	with	IN
cord-001835-0s7ok4uw	1171	34	the	the	DT
cord-001835-0s7ok4uw	1171	35	dominant	dominant	JJ
cord-001835-0s7ok4uw	1171	36	lipids	lipid	NNS
cord-001835-0s7ok4uw	1171	37	composing	compose	VBG
cord-001835-0s7ok4uw	1171	38	each	each	DT
cord-001835-0s7ok4uw	1171	39	membrane	membrane	NN
cord-001835-0s7ok4uw	1171	40	subcompartment	subcompartment	NNP
cord-001835-0s7ok4uw	1171	41	.	.	.
cord-001835-0s7ok4uw	1172	1	The	the	DT
cord-001835-0s7ok4uw	1172	2	key	key	NN
cord-001835-0s7ok4uw	1172	3	to	to	IN
cord-001835-0s7ok4uw	1172	4	understanding	understand	VBG
cord-001835-0s7ok4uw	1172	5	this	this	DT
cord-001835-0s7ok4uw	1172	6	essential	essential	JJ
cord-001835-0s7ok4uw	1172	7	molecular	molecular	JJ
cord-001835-0s7ok4uw	1172	8	switch	switch	NN
cord-001835-0s7ok4uw	1172	9	is	be	VBZ
cord-001835-0s7ok4uw	1172	10	elucidating	elucidate	VBG
cord-001835-0s7ok4uw	1172	11	at	at	IN
cord-001835-0s7ok4uw	1172	12	the	the	DT
cord-001835-0s7ok4uw	1172	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	1172	14	level	level	NN
cord-001835-0s7ok4uw	1172	15	the	the	DT
cord-001835-0s7ok4uw	1172	16	interaction	interaction	NN
cord-001835-0s7ok4uw	1172	17	of	of	IN
cord-001835-0s7ok4uw	1172	18	MA	MA	NNP
cord-001835-0s7ok4uw	1172	19	with	with	IN
cord-001835-0s7ok4uw	1172	20	specific	specific	JJ
cord-001835-0s7ok4uw	1172	21	PM	pm	NN
cord-001835-0s7ok4uw	1172	22	components	component	NNS
cord-001835-0s7ok4uw	1172	23	.	.	.
cord-001835-0s7ok4uw	1173	1	For	for	IN
cord-001835-0s7ok4uw	1173	2	over	over	IN
cord-001835-0s7ok4uw	1173	3	two	two	CD
cord-001835-0s7ok4uw	1173	4	decades	decade	NNS
cord-001835-0s7ok4uw	1173	5	,	,	,
cord-001835-0s7ok4uw	1173	6	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	1173	7	,	,	,
cord-001835-0s7ok4uw	1173	8	in	in	IN
cord-001835-0s7ok4uw	1173	9	vivo	vivo	NN
cord-001835-0s7ok4uw	1173	10	,	,	,
cord-001835-0s7ok4uw	1173	11	in	in	IN
cord-001835-0s7ok4uw	1173	12	vitro	vitro	FW
cord-001835-0s7ok4uw	1173	13	and	and	CC
cord-001835-0s7ok4uw	1173	14	genetic	genetic	JJ
cord-001835-0s7ok4uw	1173	15	studies	study	NNS
cord-001835-0s7ok4uw	1173	16	have	have	VBP
cord-001835-0s7ok4uw	1173	17	focused	focus	VBN
cord-001835-0s7ok4uw	1173	18	on	on	IN
cord-001835-0s7ok4uw	1173	19	factors	factor	NNS
cord-001835-0s7ok4uw	1173	20	that	that	WDT
cord-001835-0s7ok4uw	1173	21	modulate	modulate	VBP
cord-001835-0s7ok4uw	1173	22	binding	bind	VBG
cord-001835-0s7ok4uw	1173	23	of	of	IN
cord-001835-0s7ok4uw	1173	24	retroviral	retroviral	JJ
cord-001835-0s7ok4uw	1173	25	Gag	gag	NN
cord-001835-0s7ok4uw	1173	26	proteins	protein	NNS
cord-001835-0s7ok4uw	1173	27	to	to	IN
cord-001835-0s7ok4uw	1173	28	membranes	membrane	NNS
cord-001835-0s7ok4uw	1173	29	but	but	CC
cord-001835-0s7ok4uw	1173	30	only	only	RB
cord-001835-0s7ok4uw	1173	31	recently	recently	RB
cord-001835-0s7ok4uw	1173	32	the	the	DT
cord-001835-0s7ok4uw	1173	33	structural	structural	JJ
cord-001835-0s7ok4uw	1173	34	and	and	CC
cord-001835-0s7ok4uw	1173	35	molecular	molecular	JJ
cord-001835-0s7ok4uw	1173	36	determinants	determinant	NNS
cord-001835-0s7ok4uw	1173	37	of	of	IN
cord-001835-0s7ok4uw	1173	38	Gag	Gag	NNP
cord-001835-0s7ok4uw	1173	39	assembly	assembly	NN
cord-001835-0s7ok4uw	1173	40	have	have	VBP
cord-001835-0s7ok4uw	1173	41	begun	begin	VBN
cord-001835-0s7ok4uw	1173	42	to	to	TO
cord-001835-0s7ok4uw	1173	43	emerge	emerge	VB
cord-001835-0s7ok4uw	1173	44	.	.	.
cord-001835-0s7ok4uw	1174	1	In	in	IN
cord-001835-0s7ok4uw	1174	2	addition	addition	NN
cord-001835-0s7ok4uw	1174	3	to	to	IN
cord-001835-0s7ok4uw	1174	4	the	the	DT
cord-001835-0s7ok4uw	1174	5	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	1174	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	1174	7	between	between	IN
cord-001835-0s7ok4uw	1174	8	a	a	DT
cord-001835-0s7ok4uw	1174	9	highly	highly	RB
cord-001835-0s7ok4uw	1174	10	conserved	conserved	JJ
cord-001835-0s7ok4uw	1174	11	basic	basic	JJ
cord-001835-0s7ok4uw	1174	12	region	region	NN
cord-001835-0s7ok4uw	1174	13	of	of	IN
cord-001835-0s7ok4uw	1174	14	MA	MA	NNP
cord-001835-0s7ok4uw	1174	15	and	and	CC
cord-001835-0s7ok4uw	1174	16	acidic	acidic	JJ
cord-001835-0s7ok4uw	1174	17	phospholipids	phospholipid	NNS
cord-001835-0s7ok4uw	1174	18	,	,	,
cord-001835-0s7ok4uw	1174	19	it	-PRON-	PRP
cord-001835-0s7ok4uw	1174	20	is	be	VBZ
cord-001835-0s7ok4uw	1174	21	now	now	RB
cord-001835-0s7ok4uw	1174	22	believed	believe	VBN
cord-001835-0s7ok4uw	1174	23	that	that	IN
cord-001835-0s7ok4uw	1174	24	the	the	DT
cord-001835-0s7ok4uw	1174	25	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	1174	26	of	of	IN
cord-001835-0s7ok4uw	1174	27	the	the	DT
cord-001835-0s7ok4uw	1174	28	membrane	membrane	NN
cord-001835-0s7ok4uw	1174	29	interior	interior	NN
cord-001835-0s7ok4uw	1174	30	represented	represent	VBN
cord-001835-0s7ok4uw	1174	31	by	by	IN
cord-001835-0s7ok4uw	1174	32	the	the	DT
cord-001835-0s7ok4uw	1174	33	acyl	acyl	NN
cord-001835-0s7ok4uw	1174	34	chains	chain	NNS
cord-001835-0s7ok4uw	1174	35	and	and	CC
cord-001835-0s7ok4uw	1174	36	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	1174	37	also	also	RB
cord-001835-0s7ok4uw	1174	38	play	play	VBP
cord-001835-0s7ok4uw	1174	39	important	important	JJ
cord-001835-0s7ok4uw	1174	40	roles	role	NNS
cord-001835-0s7ok4uw	1174	41	.	.	.
cord-001835-0s7ok4uw	1175	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1175	2	employ	employ	VBP
cord-001835-0s7ok4uw	1175	3	NMR	NMR	NNP
cord-001835-0s7ok4uw	1175	4	methods	method	NNS
cord-001835-0s7ok4uw	1175	5	to	to	TO
cord-001835-0s7ok4uw	1175	6	elucidate	elucidate	VB
cord-001835-0s7ok4uw	1175	7	the	the	DT
cord-001835-0s7ok4uw	1175	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	1175	9	determinants	determinant	NNS
cord-001835-0s7ok4uw	1175	10	of	of	IN
cord-001835-0s7ok4uw	1175	11	Gag	gag	NN
cord-001835-0s7ok4uw	1175	12	binding	bind	VBG
cord-001835-0s7ok4uw	1175	13	to	to	IN
cord-001835-0s7ok4uw	1175	14	the	the	DT
cord-001835-0s7ok4uw	1175	15	membrane	membrane	NN
cord-001835-0s7ok4uw	1175	16	.	.	.
cord-001835-0s7ok4uw	1176	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1176	2	structural	structural	JJ
cord-001835-0s7ok4uw	1176	3	studies	study	NNS
cord-001835-0s7ok4uw	1176	4	revealed	reveal	VBD
cord-001835-0s7ok4uw	1176	5	that	that	IN
cord-001835-0s7ok4uw	1176	6	phosphatidylinositol-4,5-bisphosphate	phosphatidylinositol-4,5-bisphosphate	NN
cord-001835-0s7ok4uw	1176	7	(	(	-LRB-
cord-001835-0s7ok4uw	1176	8	PI	pi	NN
cord-001835-0s7ok4uw	1176	9	(	(	-LRB-
cord-001835-0s7ok4uw	1176	10	The	the	DT
cord-001835-0s7ok4uw	1176	11	production	production	NN
cord-001835-0s7ok4uw	1176	12	of	of	IN
cord-001835-0s7ok4uw	1176	13	functionally	functionally	RB
cord-001835-0s7ok4uw	1176	14	antibodies	antibody	NNS
cord-001835-0s7ok4uw	1176	15	depends	depend	VBZ
cord-001835-0s7ok4uw	1176	16	on	on	IN
cord-001835-0s7ok4uw	1176	17	the	the	DT
cord-001835-0s7ok4uw	1176	18	transition	transition	NN
cord-001835-0s7ok4uw	1176	19	of	of	IN
cord-001835-0s7ok4uw	1176	20	immature	immature	JJ
cord-001835-0s7ok4uw	1176	21	B	b	NN
cord-001835-0s7ok4uw	1176	22	cells	cell	NNS
cord-001835-0s7ok4uw	1176	23	to	to	IN
cord-001835-0s7ok4uw	1176	24	mature	mature	VB
cord-001835-0s7ok4uw	1176	25	plasma	plasma	NN
cord-001835-0s7ok4uw	1176	26	cells	cell	NNS
cord-001835-0s7ok4uw	1176	27	and	and	CC
cord-001835-0s7ok4uw	1176	28	is	be	VBZ
cord-001835-0s7ok4uw	1176	29	tightly	tightly	RB
cord-001835-0s7ok4uw	1176	30	linked	link	VBN
cord-001835-0s7ok4uw	1176	31	to	to	IN
cord-001835-0s7ok4uw	1176	32	several	several	JJ
cord-001835-0s7ok4uw	1176	33	"	"	``
cord-001835-0s7ok4uw	1176	34	quality	quality	NN
cord-001835-0s7ok4uw	1176	35	control	control	NN
cord-001835-0s7ok4uw	1176	36	"	"	''
cord-001835-0s7ok4uw	1176	37	check	check	NN
cord-001835-0s7ok4uw	1176	38	points	point	NNS
cord-001835-0s7ok4uw	1176	39	.	.	.
cord-001835-0s7ok4uw	1177	1	During	during	IN
cord-001835-0s7ok4uw	1177	2	B	b	NN
cord-001835-0s7ok4uw	1177	3	cell	cell	NN
cord-001835-0s7ok4uw	1177	4	development	development	NN
cord-001835-0s7ok4uw	1177	5	,	,	,
cord-001835-0s7ok4uw	1177	6	the	the	DT
cord-001835-0s7ok4uw	1177	7	pre	pre	NN
cord-001835-0s7ok4uw	1177	8	-	-	NN
cord-001835-0s7ok4uw	1177	9	B	b	JJ
cord-001835-0s7ok4uw	1177	10	Cell	Cell	NNP
cord-001835-0s7ok4uw	1177	11	Receptor	receptor	NN
cord-001835-0s7ok4uw	1177	12	(	(	-LRB-
cord-001835-0s7ok4uw	1177	13	pre	pre	JJ
cord-001835-0s7ok4uw	1177	14	-	-	JJ
cord-001835-0s7ok4uw	1177	15	BCR	BCR	NNP
cord-001835-0s7ok4uw	1177	16	)	)	-RRB-
cord-001835-0s7ok4uw	1177	17	is	be	VBZ
cord-001835-0s7ok4uw	1177	18	the	the	DT
cord-001835-0s7ok4uw	1177	19	first	first	JJ
cord-001835-0s7ok4uw	1177	20	checkpoint	checkpoint	NN
cord-001835-0s7ok4uw	1177	21	which	which	WDT
cord-001835-0s7ok4uw	1177	22	determines	determine	VBZ
cord-001835-0s7ok4uw	1177	23	the	the	DT
cord-001835-0s7ok4uw	1177	24	viability	viability	NN
cord-001835-0s7ok4uw	1177	25	and	and	CC
cord-001835-0s7ok4uw	1177	26	proliferation	proliferation	NN
cord-001835-0s7ok4uw	1177	27	of	of	IN
cord-001835-0s7ok4uw	1177	28	the	the	DT
cord-001835-0s7ok4uw	1177	29	pre	pre	JJ
cord-001835-0s7ok4uw	1177	30	-	-	JJ
cord-001835-0s7ok4uw	1177	31	B	b	NN
cord-001835-0s7ok4uw	1177	32	cell	cell	NN
cord-001835-0s7ok4uw	1177	33	.	.	.
cord-001835-0s7ok4uw	1178	1	The	the	DT
cord-001835-0s7ok4uw	1178	2	pre	pre	JJ
cord-001835-0s7ok4uw	1178	3	-	-	JJ
cord-001835-0s7ok4uw	1178	4	BCR	BCR	NNP
cord-001835-0s7ok4uw	1178	5	is	be	VBZ
cord-001835-0s7ok4uw	1178	6	composed	compose	VBN
cord-001835-0s7ok4uw	1178	7	of	of	IN
cord-001835-0s7ok4uw	1178	8	an	an	DT
cord-001835-0s7ok4uw	1178	9	immunoglobulin	immunoglobulin	NN
cord-001835-0s7ok4uw	1178	10	(	(	-LRB-
cord-001835-0s7ok4uw	1178	11	Ig	Ig	NNP
cord-001835-0s7ok4uw	1178	12	)	)	-RRB-
cord-001835-0s7ok4uw	1178	13	heavy	heavy	JJ
cord-001835-0s7ok4uw	1178	14	chain	chain	NN
cord-001835-0s7ok4uw	1178	15	molecule	molecule	NN
cord-001835-0s7ok4uw	1178	16	associated	associate	VBN
cord-001835-0s7ok4uw	1178	17	with	with	IN
cord-001835-0s7ok4uw	1178	18	an	an	DT
cord-001835-0s7ok4uw	1178	19	Ig	Ig	NNP
cord-001835-0s7ok4uw	1178	20	light	light	NN
cord-001835-0s7ok4uw	1178	21	chain	chain	NN
cord-001835-0s7ok4uw	1178	22	-	-	HYPH
cord-001835-0s7ok4uw	1178	23	like	like	JJ
cord-001835-0s7ok4uw	1178	24	molecule	molecule	NN
cord-001835-0s7ok4uw	1178	25	called	call	VBN
cord-001835-0s7ok4uw	1178	26	the	the	DT
cord-001835-0s7ok4uw	1178	27	Surrogate	Surrogate	NNP
cord-001835-0s7ok4uw	1178	28	Light	Light	NNP
cord-001835-0s7ok4uw	1178	29	Chain	Chain	NNP
cord-001835-0s7ok4uw	1178	30	(	(	-LRB-
cord-001835-0s7ok4uw	1178	31	SLC	SLC	NNP
cord-001835-0s7ok4uw	1178	32	)	)	-RRB-
cord-001835-0s7ok4uw	1178	33	.	.	.
cord-001835-0s7ok4uw	1179	1	The	the	DT
cord-001835-0s7ok4uw	1179	2	SLC	SLC	NNP
cord-001835-0s7ok4uw	1179	3	is	be	VBZ
cord-001835-0s7ok4uw	1179	4	composed	compose	VBN
cord-001835-0s7ok4uw	1179	5	by	by	IN
cord-001835-0s7ok4uw	1179	6	two	two	CD
cord-001835-0s7ok4uw	1179	7	proteins	protein	NNS
cord-001835-0s7ok4uw	1179	8	k5	k5	NNP
cord-001835-0s7ok4uw	1179	9	and	and	CC
cord-001835-0s7ok4uw	1179	10	VpreB	VpreB	NNP
cord-001835-0s7ok4uw	1179	11	which	which	WDT
cord-001835-0s7ok4uw	1179	12	possess	possess	VBP
cord-001835-0s7ok4uw	1179	13	a	a	DT
cord-001835-0s7ok4uw	1179	14	unique	unique	JJ
cord-001835-0s7ok4uw	1179	15	region	region	NN
cord-001835-0s7ok4uw	1179	16	at	at	IN
cord-001835-0s7ok4uw	1179	17	the	the	DT
cord-001835-0s7ok4uw	1179	18	N	N	NNP
cord-001835-0s7ok4uw	1179	19	-	-	HYPH
cord-001835-0s7ok4uw	1179	20	or	or	CC
cord-001835-0s7ok4uw	1179	21	C	c	NN
cord-001835-0s7ok4uw	1179	22	-	-	HYPH
cord-001835-0s7ok4uw	1179	23	terminus	terminus	NN
cord-001835-0s7ok4uw	1179	24	,	,	,
cord-001835-0s7ok4uw	1179	25	respectively	respectively	RB
cord-001835-0s7ok4uw	1179	26	.	.	.
cord-001835-0s7ok4uw	1180	1	VpreB	VpreB	NNP
cord-001835-0s7ok4uw	1180	2	lacks	lack	VBZ
cord-001835-0s7ok4uw	1180	3	a	a	DT
cord-001835-0s7ok4uw	1180	4	b	b	NN
cord-001835-0s7ok4uw	1180	5	-	-	HYPH
cord-001835-0s7ok4uw	1180	6	strand	strand	NN
cord-001835-0s7ok4uw	1180	7	which	which	WDT
cord-001835-0s7ok4uw	1180	8	is	be	VBZ
cord-001835-0s7ok4uw	1180	9	provided	provide	VBN
cord-001835-0s7ok4uw	1180	10	by	by	IN
cord-001835-0s7ok4uw	1180	11	the	the	DT
cord-001835-0s7ok4uw	1180	12	k5	k5	NNP
cord-001835-0s7ok4uw	1180	13	protein	protein	NN
cord-001835-0s7ok4uw	1180	14	allowing	allow	VBG
cord-001835-0s7ok4uw	1180	15	the	the	DT
cord-001835-0s7ok4uw	1180	16	non	non	JJ
cord-001835-0s7ok4uw	1180	17	-	-	JJ
cord-001835-0s7ok4uw	1180	18	covalent	covalent	JJ
cord-001835-0s7ok4uw	1180	19	interaction	interaction	NN
cord-001835-0s7ok4uw	1180	20	essential	essential	JJ
cord-001835-0s7ok4uw	1180	21	for	for	IN
cord-001835-0s7ok4uw	1180	22	formation	formation	NN
cord-001835-0s7ok4uw	1180	23	of	of	IN
cord-001835-0s7ok4uw	1180	24	the	the	DT
cord-001835-0s7ok4uw	1180	25	SLC	SLC	NNP
cord-001835-0s7ok4uw	1180	26	heterodimer	heterodimer	NN
cord-001835-0s7ok4uw	1180	27	.	.	.
cord-001835-0s7ok4uw	1181	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1181	2	understandings	understanding	NNS
cord-001835-0s7ok4uw	1181	3	of	of	IN
cord-001835-0s7ok4uw	1181	4	the	the	DT
cord-001835-0s7ok4uw	1181	5	molecular	molecular	JJ
cord-001835-0s7ok4uw	1181	6	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1181	7	of	of	IN
cord-001835-0s7ok4uw	1181	8	SLC	SLC	NNP
cord-001835-0s7ok4uw	1181	9	function	function	NN
cord-001835-0s7ok4uw	1181	10	and	and	CC
cord-001835-0s7ok4uw	1181	11	assembly	assembly	NN
cord-001835-0s7ok4uw	1181	12	are	be	VBP
cord-001835-0s7ok4uw	1181	13	still	still	RB
cord-001835-0s7ok4uw	1181	14	at	at	IN
cord-001835-0s7ok4uw	1181	15	an	an	DT
cord-001835-0s7ok4uw	1181	16	early	early	JJ
cord-001835-0s7ok4uw	1181	17	stage	stage	NN
cord-001835-0s7ok4uw	1181	18	.	.	.
cord-001835-0s7ok4uw	1182	1	In	in	IN
cord-001835-0s7ok4uw	1182	2	particular	particular	JJ
cord-001835-0s7ok4uw	1182	3	,	,	,
cord-001835-0s7ok4uw	1182	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	1182	5	do	do	VBP
cord-001835-0s7ok4uw	1182	6	not	not	RB
cord-001835-0s7ok4uw	1182	7	know	know	VB
cord-001835-0s7ok4uw	1182	8	how	how	WRB
cord-001835-0s7ok4uw	1182	9	the	the	DT
cord-001835-0s7ok4uw	1182	10	SLC	SLC	NNP
cord-001835-0s7ok4uw	1182	11	associates	associate	NNS
cord-001835-0s7ok4uw	1182	12	and	and	CC
cord-001835-0s7ok4uw	1182	13	forms	form	VBZ
cord-001835-0s7ok4uw	1182	14	the	the	DT
cord-001835-0s7ok4uw	1182	15	pre	pre	JJ
cord-001835-0s7ok4uw	1182	16	-	-	NN
cord-001835-0s7ok4uw	1182	17	BCR	BCR	NNP
cord-001835-0s7ok4uw	1182	18	for	for	IN
cord-001835-0s7ok4uw	1182	19	the	the	DT
cord-001835-0s7ok4uw	1182	20	selection	selection	NN
cord-001835-0s7ok4uw	1182	21	of	of	IN
cord-001835-0s7ok4uw	1182	22	all	all	DT
cord-001835-0s7ok4uw	1182	23	heavy	heavy	JJ
cord-001835-0s7ok4uw	1182	24	chains	chain	NNS
cord-001835-0s7ok4uw	1182	25	(	(	-LRB-
cord-001835-0s7ok4uw	1182	26	HCs	HCs	NNP
cord-001835-0s7ok4uw	1182	27	)	)	-RRB-
cord-001835-0s7ok4uw	1182	28	.	.	.
cord-001835-0s7ok4uw	1183	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1183	2	study	study	NN
cord-001835-0s7ok4uw	1183	3	focuses	focus	VBZ
cord-001835-0s7ok4uw	1183	4	on	on	IN
cord-001835-0s7ok4uw	1183	5	dissecting	dissect	VBG
cord-001835-0s7ok4uw	1183	6	the	the	DT
cord-001835-0s7ok4uw	1183	7	"	"	``
cord-001835-0s7ok4uw	1183	8	Fab	fab	JJ
cord-001835-0s7ok4uw	1183	9	fragment	fragment	NN
cord-001835-0s7ok4uw	1183	10	"	"	''
cord-001835-0s7ok4uw	1183	11	of	of	IN
cord-001835-0s7ok4uw	1183	12	the	the	DT
cord-001835-0s7ok4uw	1183	13	pre	pre	JJ
cord-001835-0s7ok4uw	1183	14	-	-	JJ
cord-001835-0s7ok4uw	1183	15	BCR	BCR	NNP
cord-001835-0s7ok4uw	1183	16	to	to	TO
cord-001835-0s7ok4uw	1183	17	study	study	VB
cord-001835-0s7ok4uw	1183	18	the	the	DT
cord-001835-0s7ok4uw	1183	19	effect	effect	NN
cord-001835-0s7ok4uw	1183	20	of	of	IN
cord-001835-0s7ok4uw	1183	21	the	the	DT
cord-001835-0s7ok4uw	1183	22	unexpected	unexpected	JJ
cord-001835-0s7ok4uw	1183	23	structural	structural	JJ
cord-001835-0s7ok4uw	1183	24	features	feature	NNS
cord-001835-0s7ok4uw	1183	25	of	of	IN
cord-001835-0s7ok4uw	1183	26	the	the	DT
cord-001835-0s7ok4uw	1183	27	SLC	SLC	NNP
cord-001835-0s7ok4uw	1183	28	to	to	TO
cord-001835-0s7ok4uw	1183	29	gain	gain	VB
cord-001835-0s7ok4uw	1183	30	insight	insight	NN
cord-001835-0s7ok4uw	1183	31	in	in	IN
cord-001835-0s7ok4uw	1183	32	HC	HC	NNP
cord-001835-0s7ok4uw	1183	33	selection	selection	NN
cord-001835-0s7ok4uw	1183	34	.	.	.
cord-001835-0s7ok4uw	1184	1	The	the	DT
cord-001835-0s7ok4uw	1184	2	analysis	analysis	NN
cord-001835-0s7ok4uw	1184	3	of	of	IN
cord-001835-0s7ok4uw	1184	4	the	the	DT
cord-001835-0s7ok4uw	1184	5	assembly	assembly	NN
cord-001835-0s7ok4uw	1184	6	of	of	IN
cord-001835-0s7ok4uw	1184	7	the	the	DT
cord-001835-0s7ok4uw	1184	8	SLC	SLC	NNP
cord-001835-0s7ok4uw	1184	9	revealed	reveal	VBD
cord-001835-0s7ok4uw	1184	10	a	a	DT
cord-001835-0s7ok4uw	1184	11	significant	significant	JJ
cord-001835-0s7ok4uw	1184	12	difference	difference	NN
cord-001835-0s7ok4uw	1184	13	between	between	IN
cord-001835-0s7ok4uw	1184	14	the	the	DT
cord-001835-0s7ok4uw	1184	15	single	single	JJ
cord-001835-0s7ok4uw	1184	16	domains	domain	NNS
cord-001835-0s7ok4uw	1184	17	and	and	CC
cord-001835-0s7ok4uw	1184	18	the	the	DT
cord-001835-0s7ok4uw	1184	19	complexes	complex	NNS
cord-001835-0s7ok4uw	1184	20	in	in	IN
cord-001835-0s7ok4uw	1184	21	terms	term	NNS
cord-001835-0s7ok4uw	1184	22	of	of	IN
cord-001835-0s7ok4uw	1184	23	stability	stability	NN
cord-001835-0s7ok4uw	1184	24	and	and	CC
cord-001835-0s7ok4uw	1184	25	assembly	assembly	NN
cord-001835-0s7ok4uw	1184	26	.	.	.
cord-001835-0s7ok4uw	1185	1	The	the	DT
cord-001835-0s7ok4uw	1185	2	folding	fold	VBG
cord-001835-0s7ok4uw	1185	3	behavior	behavior	NN
cord-001835-0s7ok4uw	1185	4	of	of	IN
cord-001835-0s7ok4uw	1185	5	the	the	DT
cord-001835-0s7ok4uw	1185	6	CH1	CH1	NNP
cord-001835-0s7ok4uw	1185	7	domain	domain	NN
cord-001835-0s7ok4uw	1185	8	in	in	IN
cord-001835-0s7ok4uw	1185	9	the	the	DT
cord-001835-0s7ok4uw	1185	10	presence	presence	NN
cord-001835-0s7ok4uw	1185	11	of	of	IN
cord-001835-0s7ok4uw	1185	12	the	the	DT
cord-001835-0s7ok4uw	1185	13	SLC	SLC	NNP
cord-001835-0s7ok4uw	1185	14	is	be	VBZ
cord-001835-0s7ok4uw	1185	15	key	key	JJ
cord-001835-0s7ok4uw	1185	16	for	for	IN
cord-001835-0s7ok4uw	1185	17	the	the	DT
cord-001835-0s7ok4uw	1185	18	first	first	JJ
cord-001835-0s7ok4uw	1185	19	quality	quality	NN
cord-001835-0s7ok4uw	1185	20	control	control	NN
cord-001835-0s7ok4uw	1185	21	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1185	22	in	in	IN
cord-001835-0s7ok4uw	1185	23	the	the	DT
cord-001835-0s7ok4uw	1185	24	endoplasmic	endoplasmic	NN
cord-001835-0s7ok4uw	1185	25	reticulum	reticulum	NN
cord-001835-0s7ok4uw	1185	26	(	(	-LRB-
cord-001835-0s7ok4uw	1185	27	ER	ER	NNP
cord-001835-0s7ok4uw	1185	28	)	)	-RRB-
cord-001835-0s7ok4uw	1185	29	prior	prior	RB
cord-001835-0s7ok4uw	1185	30	to	to	IN
cord-001835-0s7ok4uw	1185	31	surface	surface	NN
cord-001835-0s7ok4uw	1185	32	expression	expression	NN
cord-001835-0s7ok4uw	1185	33	.	.	.
cord-001835-0s7ok4uw	1186	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1186	2	results	result	NNS
cord-001835-0s7ok4uw	1186	3	show	show	VBP
cord-001835-0s7ok4uw	1186	4	that	that	IN
cord-001835-0s7ok4uw	1186	5	the	the	DT
cord-001835-0s7ok4uw	1186	6	SLC	SLC	NNP
cord-001835-0s7ok4uw	1186	7	interacts	interact	VBZ
cord-001835-0s7ok4uw	1186	8	with	with	IN
cord-001835-0s7ok4uw	1186	9	CH1	CH1	NNP
cord-001835-0s7ok4uw	1186	10	domain	domain	NN
cord-001835-0s7ok4uw	1186	11	in	in	IN
cord-001835-0s7ok4uw	1186	12	a	a	DT
cord-001835-0s7ok4uw	1186	13	similar	similar	JJ
cord-001835-0s7ok4uw	1186	14	manner	manner	NN
cord-001835-0s7ok4uw	1186	15	to	to	IN
cord-001835-0s7ok4uw	1186	16	the	the	DT
cord-001835-0s7ok4uw	1186	17	CL	CL	NNP
cord-001835-0s7ok4uw	1186	18	domain	domain	NN
cord-001835-0s7ok4uw	1186	19	.	.	.
cord-001835-0s7ok4uw	1187	1	Thus	thus	RB
cord-001835-0s7ok4uw	1187	2	,	,	,
cord-001835-0s7ok4uw	1187	3	the	the	DT
cord-001835-0s7ok4uw	1187	4	folding	folding	NN
cord-001835-0s7ok4uw	1187	5	of	of	IN
cord-001835-0s7ok4uw	1187	6	the	the	DT
cord-001835-0s7ok4uw	1187	7	naturally	naturally	RB
cord-001835-0s7ok4uw	1187	8	disordered	disordered	JJ
cord-001835-0s7ok4uw	1187	9	CH1	CH1	NNP
cord-001835-0s7ok4uw	1187	10	domain	domain	NN
cord-001835-0s7ok4uw	1187	11	upon	upon	IN
cord-001835-0s7ok4uw	1187	12	interaction	interaction	NN
cord-001835-0s7ok4uw	1187	13	with	with	IN
cord-001835-0s7ok4uw	1187	14	the	the	DT
cord-001835-0s7ok4uw	1187	15	SLC	SLC	NNP
cord-001835-0s7ok4uw	1187	16	releases	release	VBZ
cord-001835-0s7ok4uw	1187	17	the	the	DT
cord-001835-0s7ok4uw	1187	18	HC	HC	NNP
cord-001835-0s7ok4uw	1187	19	retention	retention	NN
cord-001835-0s7ok4uw	1187	20	in	in	IN
cord-001835-0s7ok4uw	1187	21	the	the	DT
cord-001835-0s7ok4uw	1187	22	ER	ER	NNP
cord-001835-0s7ok4uw	1187	23	by	by	IN
cord-001835-0s7ok4uw	1187	24	BiP.	BiP.	NNP
cord-001835-0s7ok4uw	1188	1	Taken	take	VBN
cord-001835-0s7ok4uw	1188	2	together	together	RB
cord-001835-0s7ok4uw	1188	3	,	,	,
cord-001835-0s7ok4uw	1188	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1188	5	study	study	NN
cord-001835-0s7ok4uw	1188	6	provides	provide	VBZ
cord-001835-0s7ok4uw	1188	7	new	new	JJ
cord-001835-0s7ok4uw	1188	8	insights	insight	NNS
cord-001835-0s7ok4uw	1188	9	into	into	IN
cord-001835-0s7ok4uw	1188	10	the	the	DT
cord-001835-0s7ok4uw	1188	11	folding	folding	NN
cord-001835-0s7ok4uw	1188	12	and	and	CC
cord-001835-0s7ok4uw	1188	13	assembly	assembly	NN
cord-001835-0s7ok4uw	1188	14	of	of	IN
cord-001835-0s7ok4uw	1188	15	the	the	DT
cord-001835-0s7ok4uw	1188	16	"	"	``
cord-001835-0s7ok4uw	1188	17	Fab	fab	JJ
cord-001835-0s7ok4uw	1188	18	fragment	fragment	NN
cord-001835-0s7ok4uw	1188	19	"	"	''
cord-001835-0s7ok4uw	1188	20	of	of	IN
cord-001835-0s7ok4uw	1188	21	the	the	DT
cord-001835-0s7ok4uw	1188	22	pre	pre	JJ
cord-001835-0s7ok4uw	1188	23	-	-	JJ
cord-001835-0s7ok4uw	1188	24	BCR	BCR	NNP
cord-001835-0s7ok4uw	1188	25	and	and	CC
cord-001835-0s7ok4uw	1188	26	paves	pave	VBZ
cord-001835-0s7ok4uw	1188	27	the	the	DT
cord-001835-0s7ok4uw	1188	28	way	way	NN
cord-001835-0s7ok4uw	1188	29	for	for	IN
cord-001835-0s7ok4uw	1188	30	a	a	DT
cord-001835-0s7ok4uw	1188	31	detailed	detailed	JJ
cord-001835-0s7ok4uw	1188	32	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	1188	33	understanding	understanding	NN
cord-001835-0s7ok4uw	1188	34	of	of	IN
cord-001835-0s7ok4uw	1188	35	HCs	hcs	NN
cord-001835-0s7ok4uw	1188	36	selection	selection	NN
cord-001835-0s7ok4uw	1188	37	by	by	IN
cord-001835-0s7ok4uw	1188	38	the	the	DT
cord-001835-0s7ok4uw	1188	39	unique	unique	JJ
cord-001835-0s7ok4uw	1188	40	SLC	SLC	NNP
cord-001835-0s7ok4uw	1188	41	.	.	.
cord-001835-0s7ok4uw	1189	1	Though	though	IN
cord-001835-0s7ok4uw	1189	2	the	the	DT
cord-001835-0s7ok4uw	1189	3	22	22	CD
cord-001835-0s7ok4uw	1189	4	-	-	SYM
cord-001835-0s7ok4uw	1189	5	29	29	CD
cord-001835-0s7ok4uw	1189	6	(	(	-LRB-
cord-001835-0s7ok4uw	1189	7	SFGAILSS	SFGAILSS	NNP
cord-001835-0s7ok4uw	1189	8	)	)	-RRB-
cord-001835-0s7ok4uw	1189	9	region	region	NN
cord-001835-0s7ok4uw	1189	10	of	of	IN
cord-001835-0s7ok4uw	1189	11	human	human	JJ
cord-001835-0s7ok4uw	1189	12	Islet	Islet	NNP
cord-001835-0s7ok4uw	1189	13	Amyloid	Amyloid	NNP
cord-001835-0s7ok4uw	1189	14	Polypeptide	Polypeptide	NNP
cord-001835-0s7ok4uw	1189	15	(	(	-LRB-
cord-001835-0s7ok4uw	1189	16	hIAPP	hIAPP	NNP
cord-001835-0s7ok4uw	1189	17	)	)	-RRB-
cord-001835-0s7ok4uw	1189	18	has	have	VBZ
cord-001835-0s7ok4uw	1189	19	long	long	RB
cord-001835-0s7ok4uw	1189	20	been	be	VBN
cord-001835-0s7ok4uw	1189	21	known	know	VBN
cord-001835-0s7ok4uw	1189	22	to	to	TO
cord-001835-0s7ok4uw	1189	23	be	be	VB
cord-001835-0s7ok4uw	1189	24	crucial	crucial	JJ
cord-001835-0s7ok4uw	1189	25	for	for	IN
cord-001835-0s7ok4uw	1189	26	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1189	27	fiber	fiber	NN
cord-001835-0s7ok4uw	1189	28	formation	formation	NN
cord-001835-0s7ok4uw	1189	29	,	,	,
cord-001835-0s7ok4uw	1189	30	lack	lack	NN
cord-001835-0s7ok4uw	1189	31	of	of	IN
cord-001835-0s7ok4uw	1189	32	b	b	NN
cord-001835-0s7ok4uw	1189	33	-	-	:
cord-001835-0s7ok4uw	1189	34	ordering	ordering	NN
cord-001835-0s7ok4uw	1189	35	of	of	IN
cord-001835-0s7ok4uw	1189	36	this	this	DT
cord-001835-0s7ok4uw	1189	37	region	region	NN
cord-001835-0s7ok4uw	1189	38	in	in	IN
cord-001835-0s7ok4uw	1189	39	structures	structure	NNS
cord-001835-0s7ok4uw	1189	40	of	of	IN
cord-001835-0s7ok4uw	1189	41	the	the	DT
cord-001835-0s7ok4uw	1189	42	final	final	JJ
cord-001835-0s7ok4uw	1189	43	fiber	fiber	NN
cord-001835-0s7ok4uw	1189	44	as	as	IN
cord-001835-0s7ok4uw	1189	45	determined	determine	VBN
cord-001835-0s7ok4uw	1189	46	by	by	IN
cord-001835-0s7ok4uw	1189	47	both	both	DT
cord-001835-0s7ok4uw	1189	48	NMA	NMA	NNP
cord-001835-0s7ok4uw	1189	49	and	and	CC
cord-001835-0s7ok4uw	1189	50	X	x	NN
cord-001835-0s7ok4uw	1189	51	-	-	NN
cord-001835-0s7ok4uw	1189	52	ray	ray	NN
cord-001835-0s7ok4uw	1189	53	has	have	VBZ
cord-001835-0s7ok4uw	1189	54	been	be	VBN
cord-001835-0s7ok4uw	1189	55	puzzling	puzzle	VBG
cord-001835-0s7ok4uw	1189	56	.	.	.
cord-001835-0s7ok4uw	1190	1	New	new	JJ
cord-001835-0s7ok4uw	1190	2	evidence	evidence	NN
cord-001835-0s7ok4uw	1190	3	now	now	RB
cord-001835-0s7ok4uw	1190	4	suggests	suggest	VBZ
cord-001835-0s7ok4uw	1190	5	that	that	IN
cord-001835-0s7ok4uw	1190	6	the	the	DT
cord-001835-0s7ok4uw	1190	7	FGAIL	FGAIL	NNP
cord-001835-0s7ok4uw	1190	8	region	region	NN
cord-001835-0s7ok4uw	1190	9	forms	form	NNS
cord-001835-0s7ok4uw	1190	10	ordered	order	VBN
cord-001835-0s7ok4uw	1190	11	b	b	NN
cord-001835-0s7ok4uw	1190	12	structures	structure	NNS
cord-001835-0s7ok4uw	1190	13	only	only	RB
cord-001835-0s7ok4uw	1190	14	in	in	IN
cord-001835-0s7ok4uw	1190	15	early	early	JJ
cord-001835-0s7ok4uw	1190	16	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	1190	17	.	.	.
cord-001835-0s7ok4uw	1191	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1191	2	present	present	VBP
cord-001835-0s7ok4uw	1191	3	new	new	JJ
cord-001835-0s7ok4uw	1191	4	2DIR	2dir	CD
cord-001835-0s7ok4uw	1191	5	studies	study	NNS
cord-001835-0s7ok4uw	1191	6	on	on	IN
cord-001835-0s7ok4uw	1191	7	the	the	DT
cord-001835-0s7ok4uw	1191	8	FGAIL	FGAIL	NNP
cord-001835-0s7ok4uw	1191	9	region	region	NN
cord-001835-0s7ok4uw	1191	10	of	of	IN
cord-001835-0s7ok4uw	1191	11	hIAPP	hIAPP	NNP
cord-001835-0s7ok4uw	1191	12	,	,	,
cord-001835-0s7ok4uw	1191	13	with	with	IN
cord-001835-0s7ok4uw	1191	14	uniformly	uniformly	RB
cord-001835-0s7ok4uw	1191	15	13C	13c	CD
cord-001835-0s7ok4uw	1191	16	18O	18o	CD
cord-001835-0s7ok4uw	1191	17	labeled	label	VBN
cord-001835-0s7ok4uw	1191	18	amides	amide	NNS
cord-001835-0s7ok4uw	1191	19	,	,	,
cord-001835-0s7ok4uw	1191	20	along	along	IN
cord-001835-0s7ok4uw	1191	21	with	with	IN
cord-001835-0s7ok4uw	1191	22	spectral	spectral	JJ
cord-001835-0s7ok4uw	1191	23	and	and	CC
cord-001835-0s7ok4uw	1191	24	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1191	25	modelling	modelling	NN
cord-001835-0s7ok4uw	1191	26	.	.	.
cord-001835-0s7ok4uw	1192	1	Evolution	evolution	NN
cord-001835-0s7ok4uw	1192	2	of	of	IN
cord-001835-0s7ok4uw	1192	3	the	the	DT
cord-001835-0s7ok4uw	1192	4	peak	peak	NN
cord-001835-0s7ok4uw	1192	5	frequency	frequency	NN
cord-001835-0s7ok4uw	1192	6	and	and	CC
cord-001835-0s7ok4uw	1192	7	2D	2D	NNP
cord-001835-0s7ok4uw	1192	8	lineshape	lineshape	NNP
cord-001835-0s7ok4uw	1192	9	of	of	IN
cord-001835-0s7ok4uw	1192	10	the	the	DT
cord-001835-0s7ok4uw	1192	11	labeled	label	VBN
cord-001835-0s7ok4uw	1192	12	region	region	NN
cord-001835-0s7ok4uw	1192	13	clearly	clearly	RB
cord-001835-0s7ok4uw	1192	14	present	present	VBP
cord-001835-0s7ok4uw	1192	15	a	a	DT
cord-001835-0s7ok4uw	1192	16	transition	transition	NN
cord-001835-0s7ok4uw	1192	17	from	from	IN
cord-001835-0s7ok4uw	1192	18	random	random	JJ
cord-001835-0s7ok4uw	1192	19	coil	coil	NN
cord-001835-0s7ok4uw	1192	20	to	to	IN
cord-001835-0s7ok4uw	1192	21	a	a	DT
cord-001835-0s7ok4uw	1192	22	stable	stable	JJ
cord-001835-0s7ok4uw	1192	23	b	b	NN
cord-001835-0s7ok4uw	1192	24	sheet	sheet	NN
cord-001835-0s7ok4uw	1192	25	,	,	,
cord-001835-0s7ok4uw	1192	26	a	a	DT
cord-001835-0s7ok4uw	1192	27	conclusion	conclusion	NN
cord-001835-0s7ok4uw	1192	28	which	which	WDT
cord-001835-0s7ok4uw	1192	29	is	be	VBZ
cord-001835-0s7ok4uw	1192	30	substantiated	substantiate	VBN
cord-001835-0s7ok4uw	1192	31	by	by	IN
cord-001835-0s7ok4uw	1192	32	simulation	simulation	NN
cord-001835-0s7ok4uw	1192	33	of	of	IN
cord-001835-0s7ok4uw	1192	34	the	the	DT
cord-001835-0s7ok4uw	1192	35	2D	2d	JJ
cord-001835-0s7ok4uw	1192	36	IR	IR	NNP
cord-001835-0s7ok4uw	1192	37	spectra	spectra	NNP
cord-001835-0s7ok4uw	1192	38	.	.	.
cord-001835-0s7ok4uw	1193	1	As	as	IN
cord-001835-0s7ok4uw	1193	2	determined	determine	VBN
cord-001835-0s7ok4uw	1193	3	from	from	IN
cord-001835-0s7ok4uw	1193	4	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1193	5	modeling	modeling	NN
cord-001835-0s7ok4uw	1193	6	,	,	,
cord-001835-0s7ok4uw	1193	7	the	the	DT
cord-001835-0s7ok4uw	1193	8	FGAIL	FGAIL	NNP
cord-001835-0s7ok4uw	1193	9	b	b	NN
cord-001835-0s7ok4uw	1193	10	-	-	HYPH
cord-001835-0s7ok4uw	1193	11	sheet	sheet	NN
cord-001835-0s7ok4uw	1193	12	creates	create	VBZ
cord-001835-0s7ok4uw	1193	13	a	a	DT
cord-001835-0s7ok4uw	1193	14	free	free	JJ
cord-001835-0s7ok4uw	1193	15	energy	energy	NN
cord-001835-0s7ok4uw	1193	16	barrier	barrier	NN
cord-001835-0s7ok4uw	1193	17	that	that	WDT
cord-001835-0s7ok4uw	1193	18	is	be	VBZ
cord-001835-0s7ok4uw	1193	19	the	the	DT
cord-001835-0s7ok4uw	1193	20	cause	cause	NN
cord-001835-0s7ok4uw	1193	21	of	of	IN
cord-001835-0s7ok4uw	1193	22	the	the	DT
cord-001835-0s7ok4uw	1193	23	lag	lag	NN
cord-001835-0s7ok4uw	1193	24	phase	phase	NN
cord-001835-0s7ok4uw	1193	25	during	during	IN
cord-001835-0s7ok4uw	1193	26	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1193	27	.	.	.
cord-001835-0s7ok4uw	1194	1	These	these	DT
cord-001835-0s7ok4uw	1194	2	findings	finding	NNS
cord-001835-0s7ok4uw	1194	3	help	help	VBP
cord-001835-0s7ok4uw	1194	4	to	to	TO
cord-001835-0s7ok4uw	1194	5	rationalize	rationalize	VB
cord-001835-0s7ok4uw	1194	6	a	a	DT
cord-001835-0s7ok4uw	1194	7	broad	broad	JJ
cord-001835-0s7ok4uw	1194	8	range	range	NN
cord-001835-0s7ok4uw	1194	9	of	of	IN
cord-001835-0s7ok4uw	1194	10	previous	previous	JJ
cord-001835-0s7ok4uw	1194	11	fragment	fragment	NN
cord-001835-0s7ok4uw	1194	12	and	and	CC
cord-001835-0s7ok4uw	1194	13	mutation	mutation	NN
cord-001835-0s7ok4uw	1194	14	studies	study	NNS
cord-001835-0s7ok4uw	1194	15	as	as	RB
cord-001835-0s7ok4uw	1194	16	well	well	RB
cord-001835-0s7ok4uw	1194	17	as	as	IN
cord-001835-0s7ok4uw	1194	18	provide	provide	VB
cord-001835-0s7ok4uw	1194	19	a	a	DT
cord-001835-0s7ok4uw	1194	20	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1194	21	for	for	IN
cord-001835-0s7ok4uw	1194	22	fiber	fiber	NN
cord-001835-0s7ok4uw	1194	23	formation	formation	NN
cord-001835-0s7ok4uw	1194	24	that	that	WDT
cord-001835-0s7ok4uw	1194	25	has	have	VBZ
cord-001835-0s7ok4uw	1194	26	self	self	NN
cord-001835-0s7ok4uw	1194	27	-	-	HYPH
cord-001835-0s7ok4uw	1194	28	consistent	consistent	JJ
cord-001835-0s7ok4uw	1194	29	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	1194	30	and	and	CC
cord-001835-0s7ok4uw	1194	31	structures	structure	NNS
cord-001835-0s7ok4uw	1194	32	.	.	.
cord-001835-0s7ok4uw	1195	1	The	the	DT
cord-001835-0s7ok4uw	1195	2	temperature	temperature	NN
cord-001835-0s7ok4uw	1195	3	dependence	dependence	NN
cord-001835-0s7ok4uw	1195	4	of	of	IN
cord-001835-0s7ok4uw	1195	5	protein	protein	NN
cord-001835-0s7ok4uw	1195	6	stability	stability	NN
cord-001835-0s7ok4uw	1195	7	in	in	IN
cord-001835-0s7ok4uw	1195	8	living	living	NN
cord-001835-0s7ok4uw	1195	9	cells	cell	NNS
cord-001835-0s7ok4uw	1195	10	Studies	study	NNS
cord-001835-0s7ok4uw	1195	11	addressing	address	VBG
cord-001835-0s7ok4uw	1195	12	the	the	DT
cord-001835-0s7ok4uw	1195	13	consequence	consequence	NN
cord-001835-0s7ok4uw	1195	14	of	of	IN
cord-001835-0s7ok4uw	1195	15	crowding	crowd	VBG
cord-001835-0s7ok4uw	1195	16	that	that	WDT
cord-001835-0s7ok4uw	1195	17	exist	exist	VBP
cord-001835-0s7ok4uw	1195	18	in	in	IN
cord-001835-0s7ok4uw	1195	19	the	the	DT
cord-001835-0s7ok4uw	1195	20	interior	interior	NN
cord-001835-0s7ok4uw	1195	21	of	of	IN
cord-001835-0s7ok4uw	1195	22	cells	cell	NNS
cord-001835-0s7ok4uw	1195	23	have	have	VBP
cord-001835-0s7ok4uw	1195	24	reached	reach	VBN
cord-001835-0s7ok4uw	1195	25	an	an	DT
cord-001835-0s7ok4uw	1195	26	interesting	interesting	JJ
cord-001835-0s7ok4uw	1195	27	stage	stage	NN
cord-001835-0s7ok4uw	1195	28	.	.	.
cord-001835-0s7ok4uw	1196	1	Experimental	experimental	JJ
cord-001835-0s7ok4uw	1196	2	data	datum	NNS
cord-001835-0s7ok4uw	1196	3	so	so	RB
cord-001835-0s7ok4uw	1196	4	far	far	RB
cord-001835-0s7ok4uw	1196	5	,	,	,
cord-001835-0s7ok4uw	1196	6	predominantly	predominantly	RB
cord-001835-0s7ok4uw	1196	7	from	from	IN
cord-001835-0s7ok4uw	1196	8	,	,	,
cord-001835-0s7ok4uw	1196	9	small	small	JJ
cord-001835-0s7ok4uw	1196	10	to	to	TO
cord-001835-0s7ok4uw	1196	11	medium	medium	JJ
cord-001835-0s7ok4uw	1196	12	sized	sized	JJ
cord-001835-0s7ok4uw	1196	13	proteins	protein	NNS
cord-001835-0s7ok4uw	1196	14	are	be	VBP
cord-001835-0s7ok4uw	1196	15	indicating	indicate	VBG
cord-001835-0s7ok4uw	1196	16	that	that	IN
cord-001835-0s7ok4uw	1196	17	,	,	,
cord-001835-0s7ok4uw	1196	18	in	in	IN
cord-001835-0s7ok4uw	1196	19	general	general	JJ
cord-001835-0s7ok4uw	1196	20	,	,	,
cord-001835-0s7ok4uw	1196	21	natively	natively	RB
cord-001835-0s7ok4uw	1196	22	folded	fold	VBN
cord-001835-0s7ok4uw	1196	23	proteins	protein	NNS
cord-001835-0s7ok4uw	1196	24	including	include	VBG
cord-001835-0s7ok4uw	1196	25	,	,	,
cord-001835-0s7ok4uw	1196	26	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	1196	27	disordered	disordered	JJ
cord-001835-0s7ok4uw	1196	28	,	,	,
cord-001835-0s7ok4uw	1196	29	gain	gain	VB
cord-001835-0s7ok4uw	1196	30	structure	structure	NN
cord-001835-0s7ok4uw	1196	31	and	and	CC
cord-001835-0s7ok4uw	1196	32	stability	stability	NN
cord-001835-0s7ok4uw	1196	33	under	under	IN
cord-001835-0s7ok4uw	1196	34	conditions	condition	NNS
cord-001835-0s7ok4uw	1196	35	mimicking	mimic	VBG
cord-001835-0s7ok4uw	1196	36	cell	cell	NN
cord-001835-0s7ok4uw	1196	37	interior	interior	NN
cord-001835-0s7ok4uw	1196	38	.	.	.
cord-001835-0s7ok4uw	1197	1	However	however	RB
cord-001835-0s7ok4uw	1197	2	,	,	,
cord-001835-0s7ok4uw	1197	3	on	on	IN
cord-001835-0s7ok4uw	1197	4	the	the	DT
cord-001835-0s7ok4uw	1197	5	other	other	JJ
cord-001835-0s7ok4uw	1197	6	hand	hand	NN
cord-001835-0s7ok4uw	1197	7	,	,	,
cord-001835-0s7ok4uw	1197	8	a	a	DT
cord-001835-0s7ok4uw	1197	9	few	few	JJ
cord-001835-0s7ok4uw	1197	10	studies	study	NNS
cord-001835-0s7ok4uw	1197	11	on	on	IN
cord-001835-0s7ok4uw	1197	12	small	small	JJ
cord-001835-0s7ok4uw	1197	13	proteins	protein	NNS
cord-001835-0s7ok4uw	1197	14	indicate	indicate	VBP
cord-001835-0s7ok4uw	1197	15	destabilization	destabilization	NN
cord-001835-0s7ok4uw	1197	16	of	of	IN
cord-001835-0s7ok4uw	1197	17	the	the	DT
cord-001835-0s7ok4uw	1197	18	native	native	JJ
cord-001835-0s7ok4uw	1197	19	state	state	NN
cord-001835-0s7ok4uw	1197	20	.	.	.
cord-001835-0s7ok4uw	1198	1	In	in	IN
cord-001835-0s7ok4uw	1198	2	very	very	RB
cord-001835-0s7ok4uw	1198	3	few	few	JJ
cord-001835-0s7ok4uw	1198	4	instances	instance	NNS
cord-001835-0s7ok4uw	1198	5	,	,	,
cord-001835-0s7ok4uw	1198	6	crowding	crowd	VBG
cord-001835-0s7ok4uw	1198	7	resulted	result	VBD
cord-001835-0s7ok4uw	1198	8	in	in	IN
cord-001835-0s7ok4uw	1198	9	compaction	compaction	NN
cord-001835-0s7ok4uw	1198	10	and	and	CC
cord-001835-0s7ok4uw	1198	11	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1198	12	of	of	IN
cord-001835-0s7ok4uw	1198	13	the	the	DT
cord-001835-0s7ok4uw	1198	14	unfolded	unfolded	JJ
cord-001835-0s7ok4uw	1198	15	and	and	CC
cord-001835-0s7ok4uw	1198	16	partially	partially	RB
cord-001835-0s7ok4uw	1198	17	folded	fold	VBN
cord-001835-0s7ok4uw	1198	18	states	state	NNS
cord-001835-0s7ok4uw	1198	19	.	.	.
cord-001835-0s7ok4uw	1199	1	Experimental	experimental	JJ
cord-001835-0s7ok4uw	1199	2	data	datum	NNS
cord-001835-0s7ok4uw	1199	3	on	on	IN
cord-001835-0s7ok4uw	1199	4	the	the	DT
cord-001835-0s7ok4uw	1199	5	consequences	consequence	NNS
cord-001835-0s7ok4uw	1199	6	of	of	IN
cord-001835-0s7ok4uw	1199	7	cell	cell	NN
cord-001835-0s7ok4uw	1199	8	-	-	HYPH
cord-001835-0s7ok4uw	1199	9	like	like	JJ
cord-001835-0s7ok4uw	1199	10	crowding	crowd	VBG
cord-001835-0s7ok4uw	1199	11	situation	situation	NN
cord-001835-0s7ok4uw	1199	12	on	on	IN
cord-001835-0s7ok4uw	1199	13	relatively	relatively	RB
cord-001835-0s7ok4uw	1199	14	large	large	JJ
cord-001835-0s7ok4uw	1199	15	proteins	protein	NNS
cord-001835-0s7ok4uw	1199	16	with	with	IN
cord-001835-0s7ok4uw	1199	17	complex	complex	JJ
cord-001835-0s7ok4uw	1199	18	folding	fold	VBG
cord-001835-0s7ok4uw	1199	19	free	free	JJ
cord-001835-0s7ok4uw	1199	20	energy	energy	NN
cord-001835-0s7ok4uw	1199	21	landscape	landscape	NN
cord-001835-0s7ok4uw	1199	22	are	be	VBP
cord-001835-0s7ok4uw	1199	23	absent	absent	JJ
cord-001835-0s7ok4uw	1199	24	.	.	.
cord-001835-0s7ok4uw	1200	1	alpha	alpha	NN
cord-001835-0s7ok4uw	1200	2	subunit	subunit	NN
cord-001835-0s7ok4uw	1200	3	of	of	IN
cord-001835-0s7ok4uw	1200	4	tryptophan	tryptophan	NNP
cord-001835-0s7ok4uw	1200	5	synthase	synthase	NNP
cord-001835-0s7ok4uw	1200	6	,	,	,
cord-001835-0s7ok4uw	1200	7	a	a	DT
cord-001835-0s7ok4uw	1200	8	29	29	CD
cord-001835-0s7ok4uw	1200	9	kDa	kDa	NNP
cord-001835-0s7ok4uw	1200	10	TIM	TIM	NNP
cord-001835-0s7ok4uw	1200	11	barrel	barrel	NN
cord-001835-0s7ok4uw	1200	12	protein	protein	NN
cord-001835-0s7ok4uw	1200	13	,	,	,
cord-001835-0s7ok4uw	1200	14	provides	provide	VBZ
cord-001835-0s7ok4uw	1200	15	a	a	DT
cord-001835-0s7ok4uw	1200	16	unique	unique	JJ
cord-001835-0s7ok4uw	1200	17	opportunity	opportunity	NN
cord-001835-0s7ok4uw	1200	18	to	to	TO
cord-001835-0s7ok4uw	1200	19	address	address	VB
cord-001835-0s7ok4uw	1200	20	the	the	DT
cord-001835-0s7ok4uw	1200	21	consequence	consequence	NN
cord-001835-0s7ok4uw	1200	22	of	of	IN
cord-001835-0s7ok4uw	1200	23	crowding	crowd	VBG
cord-001835-0s7ok4uw	1200	24	on	on	IN
cord-001835-0s7ok4uw	1200	25	the	the	DT
cord-001835-0s7ok4uw	1200	26	structure	structure	NN
cord-001835-0s7ok4uw	1200	27	and	and	CC
cord-001835-0s7ok4uw	1200	28	stability	stability	NN
cord-001835-0s7ok4uw	1200	29	of	of	IN
cord-001835-0s7ok4uw	1200	30	the	the	DT
cord-001835-0s7ok4uw	1200	31	native	native	JJ
cord-001835-0s7ok4uw	1200	32	state	state	NN
cord-001835-0s7ok4uw	1200	33	and	and	CC
cord-001835-0s7ok4uw	1200	34	also	also	RB
cord-001835-0s7ok4uw	1200	35	on	on	IN
cord-001835-0s7ok4uw	1200	36	a	a	DT
cord-001835-0s7ok4uw	1200	37	partially	partially	RB
cord-001835-0s7ok4uw	1200	38	folded	fold	VBN
cord-001835-0s7ok4uw	1200	39	state	state	NN
cord-001835-0s7ok4uw	1200	40	stable	stable	JJ
cord-001835-0s7ok4uw	1200	41	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	1200	42	intermediate	intermediate	NN
cord-001835-0s7ok4uw	1200	43	populated	populate	VBN
cord-001835-0s7ok4uw	1200	44	in	in	IN
cord-001835-0s7ok4uw	1200	45	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1200	46	(	(	-LRB-
cord-001835-0s7ok4uw	1200	47	un)folding	un)folding	NN
cord-001835-0s7ok4uw	1200	48	reactions	reaction	NNS
cord-001835-0s7ok4uw	1200	49	.	.	.
cord-001835-0s7ok4uw	1201	1	In	in	IN
cord-001835-0s7ok4uw	1201	2	the	the	DT
cord-001835-0s7ok4uw	1201	3	presence	presence	NN
cord-001835-0s7ok4uw	1201	4	of	of	IN
cord-001835-0s7ok4uw	1201	5	increasing	increase	VBG
cord-001835-0s7ok4uw	1201	6	amounts	amount	NNS
cord-001835-0s7ok4uw	1201	7	the	the	DT
cord-001835-0s7ok4uw	1201	8	most	most	RBS
cord-001835-0s7ok4uw	1201	9	commonly	commonly	RB
cord-001835-0s7ok4uw	1201	10	used	use	VBN
cord-001835-0s7ok4uw	1201	11	crowding	crowding	NN
cord-001835-0s7ok4uw	1201	12	agent	agent	NN
cord-001835-0s7ok4uw	1201	13	,	,	,
cord-001835-0s7ok4uw	1201	14	Ficoll-70	Ficoll-70	NNP
cord-001835-0s7ok4uw	1201	15	,	,	,
cord-001835-0s7ok4uw	1201	16	a	a	DT
cord-001835-0s7ok4uw	1201	17	non	non	JJ
cord-001835-0s7ok4uw	1201	18	-	-	JJ
cord-001835-0s7ok4uw	1201	19	monotonous	monotonous	JJ
cord-001835-0s7ok4uw	1201	20	increase	increase	NN
cord-001835-0s7ok4uw	1201	21	in	in	IN
cord-001835-0s7ok4uw	1201	22	the	the	DT
cord-001835-0s7ok4uw	1201	23	far	far	JJ
cord-001835-0s7ok4uw	1201	24	UV	uv	NN
cord-001835-0s7ok4uw	1201	25	-	-	HYPH
cord-001835-0s7ok4uw	1201	26	CD	CD	NNP
cord-001835-0s7ok4uw	1201	27	is	be	VBZ
cord-001835-0s7ok4uw	1201	28	observed	observe	VBN
cord-001835-0s7ok4uw	1201	29	for	for	IN
cord-001835-0s7ok4uw	1201	30	the	the	DT
cord-001835-0s7ok4uw	1201	31	native	native	JJ
cord-001835-0s7ok4uw	1201	32	state	state	NN
cord-001835-0s7ok4uw	1201	33	.	.	.
cord-001835-0s7ok4uw	1202	1	A	a	DT
cord-001835-0s7ok4uw	1202	2	steady	steady	JJ
cord-001835-0s7ok4uw	1202	3	increase	increase	NN
cord-001835-0s7ok4uw	1202	4	up	up	RP
cord-001835-0s7ok4uw	1202	5	to	to	IN
cord-001835-0s7ok4uw	1202	6	250mg	250mg	NNP
cord-001835-0s7ok4uw	1202	7	/	/	SYM
cord-001835-0s7ok4uw	1202	8	ml	ml	CC
cord-001835-0s7ok4uw	1202	9	Ficoll	Ficoll	NNP
cord-001835-0s7ok4uw	1202	10	followed	follow	VBD
cord-001835-0s7ok4uw	1202	11	by	by	IN
cord-001835-0s7ok4uw	1202	12	a	a	DT
cord-001835-0s7ok4uw	1202	13	decrease	decrease	NN
cord-001835-0s7ok4uw	1202	14	in	in	IN
cord-001835-0s7ok4uw	1202	15	far	far	JJ
cord-001835-0s7ok4uw	1202	16	-	-	HYPH
cord-001835-0s7ok4uw	1202	17	UV	uv	NN
cord-001835-0s7ok4uw	1202	18	CD	cd	NN
cord-001835-0s7ok4uw	1202	19	region	region	NN
cord-001835-0s7ok4uw	1202	20	is	be	VBZ
cord-001835-0s7ok4uw	1202	21	observed	observe	VBN
cord-001835-0s7ok4uw	1202	22	,	,	,
cord-001835-0s7ok4uw	1202	23	indicating	indicate	VBG
cord-001835-0s7ok4uw	1202	24	loss	loss	NN
cord-001835-0s7ok4uw	1202	25	of	of	IN
cord-001835-0s7ok4uw	1202	26	structure	structure	NN
cord-001835-0s7ok4uw	1202	27	at	at	IN
cord-001835-0s7ok4uw	1202	28	increased	increase	VBN
cord-001835-0s7ok4uw	1202	29	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1202	30	of	of	IN
cord-001835-0s7ok4uw	1202	31	the	the	DT
cord-001835-0s7ok4uw	1202	32	crowding	crowd	VBG
cord-001835-0s7ok4uw	1202	33	agent	agent	NN
cord-001835-0s7ok4uw	1202	34	.	.	.
cord-001835-0s7ok4uw	1203	1	1H-15N	1H-15N	NNP
cord-001835-0s7ok4uw	1203	2	HSQC	HSQC	NNP
cord-001835-0s7ok4uw	1203	3	NMR	NMR	NNP
cord-001835-0s7ok4uw	1203	4	and	and	CC
cord-001835-0s7ok4uw	1203	5	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1203	6	(	(	-LRB-
cord-001835-0s7ok4uw	1203	7	FL	FL	NNP
cord-001835-0s7ok4uw	1203	8	)	)	-RRB-
cord-001835-0s7ok4uw	1203	9	spectra	spectrum	NNS
cord-001835-0s7ok4uw	1203	10	confirm	confirm	VBP
cord-001835-0s7ok4uw	1203	11	the	the	DT
cord-001835-0s7ok4uw	1203	12	of	of	IN
cord-001835-0s7ok4uw	1203	13	loss	loss	NN
cord-001835-0s7ok4uw	1203	14	of	of	IN
cord-001835-0s7ok4uw	1203	15	structure	structure	NN
cord-001835-0s7ok4uw	1203	16	at	at	IN
cord-001835-0s7ok4uw	1203	17	higher	high	JJR
cord-001835-0s7ok4uw	1203	18	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1203	19	of	of	IN
cord-001835-0s7ok4uw	1203	20	Ficoll-70	Ficoll-70	NNS
cord-001835-0s7ok4uw	1203	21	.	.	.
cord-001835-0s7ok4uw	1204	1	Loss	loss	NN
cord-001835-0s7ok4uw	1204	2	of	of	IN
cord-001835-0s7ok4uw	1204	3	native	native	JJ
cord-001835-0s7ok4uw	1204	4	base	base	NN
cord-001835-0s7ok4uw	1204	5	line	line	NN
cord-001835-0s7ok4uw	1204	6	in	in	IN
cord-001835-0s7ok4uw	1204	7	the	the	DT
cord-001835-0s7ok4uw	1204	8	urea	urea	NN
cord-001835-0s7ok4uw	1204	9	induced	induce	VBN
cord-001835-0s7ok4uw	1204	10	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1204	11	reaction	reaction	NN
cord-001835-0s7ok4uw	1204	12	monitored	monitor	VBN
cord-001835-0s7ok4uw	1204	13	by	by	IN
cord-001835-0s7ok4uw	1204	14	CD	CD	NNP
cord-001835-0s7ok4uw	1204	15	and	and	CC
cord-001835-0s7ok4uw	1204	16	FL	FL	NNP
cord-001835-0s7ok4uw	1204	17	clearly	clearly	RB
cord-001835-0s7ok4uw	1204	18	confirms	confirm	VBZ
cord-001835-0s7ok4uw	1204	19	the	the	DT
cord-001835-0s7ok4uw	1204	20	destabilization	destabilization	NN
cord-001835-0s7ok4uw	1204	21	of	of	IN
cord-001835-0s7ok4uw	1204	22	the	the	DT
cord-001835-0s7ok4uw	1204	23	native	native	JJ
cord-001835-0s7ok4uw	1204	24	state	state	NN
cord-001835-0s7ok4uw	1204	25	.	.	.
cord-001835-0s7ok4uw	1205	1	Similar	similar	JJ
cord-001835-0s7ok4uw	1205	2	to	to	IN
cord-001835-0s7ok4uw	1205	3	the	the	DT
cord-001835-0s7ok4uw	1205	4	structural	structural	JJ
cord-001835-0s7ok4uw	1205	5	changes	change	NNS
cord-001835-0s7ok4uw	1205	6	observed	observe	VBN
cord-001835-0s7ok4uw	1205	7	for	for	IN
cord-001835-0s7ok4uw	1205	8	the	the	DT
cord-001835-0s7ok4uw	1205	9	native	native	JJ
cord-001835-0s7ok4uw	1205	10	state	state	NN
cord-001835-0s7ok4uw	1205	11	,	,	,
cord-001835-0s7ok4uw	1205	12	for	for	IN
cord-001835-0s7ok4uw	1205	13	the	the	DT
cord-001835-0s7ok4uw	1205	14	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	1206	1	intermediate	intermediate	JJ
cord-001835-0s7ok4uw	1206	2	state	state	NNP
cord-001835-0s7ok4uw	1206	3	maximally	maximally	RB
cord-001835-0s7ok4uw	1206	4	populated	populated	JJ
cord-001835-0s7ok4uw	1206	5	at	at	IN
cord-001835-0s7ok4uw	1206	6	3	3	CD
cord-001835-0s7ok4uw	1206	7	M	M	NNP
cord-001835-0s7ok4uw	1206	8	urea	urea	NN
cord-001835-0s7ok4uw	1206	9	also	also	RB
cord-001835-0s7ok4uw	1206	10	,	,	,
cord-001835-0s7ok4uw	1206	11	non	non	JJ
cord-001835-0s7ok4uw	1206	12	-	-	JJ
cord-001835-0s7ok4uw	1206	13	monotonous	monotonous	JJ
cord-001835-0s7ok4uw	1206	14	changes	change	NNS
cord-001835-0s7ok4uw	1206	15	in	in	IN
cord-001835-0s7ok4uw	1206	16	the	the	DT
cord-001835-0s7ok4uw	1206	17	far	far	JJ
cord-001835-0s7ok4uw	1206	18	UV	uv	NN
cord-001835-0s7ok4uw	1206	19	CD	cd	NN
cord-001835-0s7ok4uw	1206	20	and	and	CC
cord-001835-0s7ok4uw	1206	21	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1206	22	spectra	spectrum	NNS
cord-001835-0s7ok4uw	1206	23	are	be	VBP
cord-001835-0s7ok4uw	1206	24	observed	observe	VBN
cord-001835-0s7ok4uw	1206	25	.	.	.
cord-001835-0s7ok4uw	1207	1	The	the	DT
cord-001835-0s7ok4uw	1207	2	highly	highly	RB
cord-001835-0s7ok4uw	1207	3	populated	populated	JJ
cord-001835-0s7ok4uw	1207	4	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	1207	5	intermediate	intermediate	NN
cord-001835-0s7ok4uw	1207	6	shows	show	VBZ
cord-001835-0s7ok4uw	1207	7	an	an	DT
cord-001835-0s7ok4uw	1207	8	initial	initial	JJ
cord-001835-0s7ok4uw	1207	9	steady	steady	JJ
cord-001835-0s7ok4uw	1207	10	increase	increase	NN
cord-001835-0s7ok4uw	1207	11	in	in	IN
cord-001835-0s7ok4uw	1207	12	the	the	DT
cord-001835-0s7ok4uw	1207	13	far	far	JJ
cord-001835-0s7ok4uw	1207	14	UV	uv	NN
cord-001835-0s7ok4uw	1207	15	CD	cd	NN
cord-001835-0s7ok4uw	1207	16	signal	signal	NN
cord-001835-0s7ok4uw	1207	17	followed	follow	VBN
cord-001835-0s7ok4uw	1207	18	by	by	IN
cord-001835-0s7ok4uw	1207	19	a	a	DT
cord-001835-0s7ok4uw	1207	20	sudden	sudden	JJ
cord-001835-0s7ok4uw	1207	21	decrease	decrease	NN
cord-001835-0s7ok4uw	1207	22	.	.	.
cord-001835-0s7ok4uw	1208	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1208	2	results	result	NNS
cord-001835-0s7ok4uw	1208	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	1208	4	that	that	IN
cord-001835-0s7ok4uw	1208	5	the	the	DT
cord-001835-0s7ok4uw	1208	6	structure	structure	NN
cord-001835-0s7ok4uw	1208	7	of	of	IN
cord-001835-0s7ok4uw	1208	8	both	both	CC
cord-001835-0s7ok4uw	1208	9	native	native	JJ
cord-001835-0s7ok4uw	1208	10	and	and	CC
cord-001835-0s7ok4uw	1208	11	partially	partially	RB
cord-001835-0s7ok4uw	1208	12	folded	fold	VBN
cord-001835-0s7ok4uw	1208	13	states	state	NNS
cord-001835-0s7ok4uw	1208	14	may	may	MD
cord-001835-0s7ok4uw	1208	15	be	be	VB
cord-001835-0s7ok4uw	1208	16	affected	affect	VBN
cord-001835-0s7ok4uw	1208	17	under	under	IN
cord-001835-0s7ok4uw	1208	18	crowding	crowd	VBG
cord-001835-0s7ok4uw	1208	19	conditions	condition	NNS
cord-001835-0s7ok4uw	1208	20	.	.	.
cord-001835-0s7ok4uw	1209	1	Alpha-1	alpha-1	JJ
cord-001835-0s7ok4uw	1209	2	antitrypsin	antitrypsin	NN
cord-001835-0s7ok4uw	1209	3	(	(	-LRB-
cord-001835-0s7ok4uw	1209	4	AAT	AAT	NNP
cord-001835-0s7ok4uw	1209	5	)	)	-RRB-
cord-001835-0s7ok4uw	1209	6	is	be	VBZ
cord-001835-0s7ok4uw	1209	7	a	a	DT
cord-001835-0s7ok4uw	1209	8	44-kDa	44-kda	CD
cord-001835-0s7ok4uw	1209	9	serine	serine	NN
cord-001835-0s7ok4uw	1209	10	protein	protein	NN
cord-001835-0s7ok4uw	1209	11	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	1209	12	(	(	-LRB-
cord-001835-0s7ok4uw	1209	13	serpin	serpin	NNP
cord-001835-0s7ok4uw	1209	14	)	)	-RRB-
cord-001835-0s7ok4uw	1209	15	,	,	,
cord-001835-0s7ok4uw	1209	16	which	which	WDT
cord-001835-0s7ok4uw	1209	17	acts	act	VBZ
cord-001835-0s7ok4uw	1209	18	as	as	IN
cord-001835-0s7ok4uw	1209	19	an	an	DT
cord-001835-0s7ok4uw	1209	20	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	1209	21	of	of	IN
cord-001835-0s7ok4uw	1209	22	neutrophil	neutrophil	NN
cord-001835-0s7ok4uw	1209	23	elastase	elastase	NN
cord-001835-0s7ok4uw	1209	24	within	within	IN
cord-001835-0s7ok4uw	1209	25	the	the	DT
cord-001835-0s7ok4uw	1209	26	lungs	lung	NNS
cord-001835-0s7ok4uw	1209	27	.	.	.
cord-001835-0s7ok4uw	1210	1	During	during	IN
cord-001835-0s7ok4uw	1210	2	inhibition	inhibition	NN
cord-001835-0s7ok4uw	1210	3	,	,	,
cord-001835-0s7ok4uw	1210	4	the	the	DT
cord-001835-0s7ok4uw	1210	5	protein	protein	NN
cord-001835-0s7ok4uw	1210	6	undergoes	undergo	VBZ
cord-001835-0s7ok4uw	1210	7	a	a	DT
cord-001835-0s7ok4uw	1210	8	dramatic	dramatic	JJ
cord-001835-0s7ok4uw	1210	9	conformational	conformational	JJ
cord-001835-0s7ok4uw	1210	10	change	change	NN
cord-001835-0s7ok4uw	1210	11	in	in	IN
cord-001835-0s7ok4uw	1210	12	which	which	WDT
cord-001835-0s7ok4uw	1210	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1210	14	exposed	expose	VBN
cord-001835-0s7ok4uw	1210	15	reactive	reactive	JJ
cord-001835-0s7ok4uw	1210	16	centre	centre	NN
cord-001835-0s7ok4uw	1210	17	loop	loop	NN
cord-001835-0s7ok4uw	1210	18	(	(	-LRB-
cord-001835-0s7ok4uw	1210	19	RCL	RCL	NNP
cord-001835-0s7ok4uw	1210	20	)	)	-RRB-
cord-001835-0s7ok4uw	1210	21	is	be	VBZ
cord-001835-0s7ok4uw	1210	22	cleaved	cleave	VBN
cord-001835-0s7ok4uw	1210	23	and	and	CC
cord-001835-0s7ok4uw	1210	24	inserts	insert	NNS
cord-001835-0s7ok4uw	1210	25	into	into	IN
cord-001835-0s7ok4uw	1210	26	the	the	DT
cord-001835-0s7ok4uw	1210	27	central	central	JJ
cord-001835-0s7ok4uw	1210	28	A	A	NNP
cord-001835-0s7ok4uw	1210	29	-	-	HYPH
cord-001835-0s7ok4uw	1210	30	sheet	sheet	NN
cord-001835-0s7ok4uw	1210	31	as	as	IN
cord-001835-0s7ok4uw	1210	32	an	an	DT
cord-001835-0s7ok4uw	1210	33	extra	extra	JJ
cord-001835-0s7ok4uw	1210	34	beta	beta	NN
cord-001835-0s7ok4uw	1210	35	-	-	HYPH
cord-001835-0s7ok4uw	1210	36	strand	strand	NN
cord-001835-0s7ok4uw	1210	37	.	.	.
cord-001835-0s7ok4uw	1211	1	This	this	DT
cord-001835-0s7ok4uw	1211	2	highly	highly	RB
cord-001835-0s7ok4uw	1211	3	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	1211	4	protein	protein	NN
cord-001835-0s7ok4uw	1211	5	is	be	VBZ
cord-001835-0s7ok4uw	1211	6	also	also	RB
cord-001835-0s7ok4uw	1211	7	susceptible	susceptible	JJ
cord-001835-0s7ok4uw	1211	8	to	to	IN
cord-001835-0s7ok4uw	1211	9	mutations	mutation	NNS
cord-001835-0s7ok4uw	1211	10	,	,	,
cord-001835-0s7ok4uw	1211	11	resulting	result	VBG
cord-001835-0s7ok4uw	1211	12	in	in	IN
cord-001835-0s7ok4uw	1211	13	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	1211	14	and	and	CC
cord-001835-0s7ok4uw	1211	15	the	the	DT
cord-001835-0s7ok4uw	1211	16	accumulation	accumulation	NN
cord-001835-0s7ok4uw	1211	17	of	of	IN
cord-001835-0s7ok4uw	1211	18	ordered	order	VBN
cord-001835-0s7ok4uw	1211	19	polymers	polymer	NNS
cord-001835-0s7ok4uw	1211	20	as	as	IN
cord-001835-0s7ok4uw	1211	21	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	1211	22	inclusions	inclusion	NNS
cord-001835-0s7ok4uw	1211	23	within	within	IN
cord-001835-0s7ok4uw	1211	24	the	the	DT
cord-001835-0s7ok4uw	1211	25	endoplasmic	endoplasmic	NN
cord-001835-0s7ok4uw	1211	26	reticulum	reticulum	NN
cord-001835-0s7ok4uw	1211	27	of	of	IN
cord-001835-0s7ok4uw	1211	28	hepatocytes	hepatocyte	NNS
cord-001835-0s7ok4uw	1211	29	,	,	,
cord-001835-0s7ok4uw	1211	30	where	where	WRB
cord-001835-0s7ok4uw	1211	31	AAT	AAT	NNP
cord-001835-0s7ok4uw	1211	32	is	be	VBZ
cord-001835-0s7ok4uw	1211	33	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	1211	34	.	.	.
cord-001835-0s7ok4uw	1212	1	Despite	despite	IN
cord-001835-0s7ok4uw	1212	2	much	much	JJ
cord-001835-0s7ok4uw	1212	3	knowledge	knowledge	NN
cord-001835-0s7ok4uw	1212	4	of	of	IN
cord-001835-0s7ok4uw	1212	5	the	the	DT
cord-001835-0s7ok4uw	1212	6	folding	folding	NN
cord-001835-0s7ok4uw	1212	7	and	and	CC
cord-001835-0s7ok4uw	1212	8	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	1212	9	properties	property	NNS
cord-001835-0s7ok4uw	1212	10	of	of	IN
cord-001835-0s7ok4uw	1212	11	AAT	AAT	NNP
cord-001835-0s7ok4uw	1212	12	as	as	IN
cord-001835-0s7ok4uw	1212	13	an	an	DT
cord-001835-0s7ok4uw	1212	14	isolated	isolated	JJ
cord-001835-0s7ok4uw	1212	15	protein	protein	NN
cord-001835-0s7ok4uw	1212	16	,	,	,
cord-001835-0s7ok4uw	1212	17	very	very	RB
cord-001835-0s7ok4uw	1212	18	little	little	JJ
cord-001835-0s7ok4uw	1212	19	is	be	VBZ
cord-001835-0s7ok4uw	1212	20	understood	understand	VBN
cord-001835-0s7ok4uw	1212	21	of	of	IN
cord-001835-0s7ok4uw	1212	22	how	how	WRB
cord-001835-0s7ok4uw	1212	23	AAT	AAT	NNP
cord-001835-0s7ok4uw	1212	24	acquires	acquire	VBZ
cord-001835-0s7ok4uw	1212	25	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1212	26	structure	structure	NN
cord-001835-0s7ok4uw	1212	27	during	during	IN
cord-001835-0s7ok4uw	1212	28	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	1212	29	.	.	.
cord-001835-0s7ok4uw	1213	1	Like	like	IN
cord-001835-0s7ok4uw	1213	2	all	all	DT
cord-001835-0s7ok4uw	1213	3	proteins	protein	NNS
cord-001835-0s7ok4uw	1213	4	,	,	,
cord-001835-0s7ok4uw	1213	5	the	the	DT
cord-001835-0s7ok4uw	1213	6	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	1213	7	of	of	IN
cord-001835-0s7ok4uw	1213	8	AAT	AAT	NNP
cord-001835-0s7ok4uw	1213	9	takes	take	VBZ
cord-001835-0s7ok4uw	1213	10	place	place	NN
cord-001835-0s7ok4uw	1213	11	on	on	IN
cord-001835-0s7ok4uw	1213	12	the	the	DT
cord-001835-0s7ok4uw	1213	13	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1213	14	,	,	,
cord-001835-0s7ok4uw	1213	15	and	and	CC
cord-001835-0s7ok4uw	1213	16	protein	protein	NN
cord-001835-0s7ok4uw	1213	17	folding	folding	NN
cord-001835-0s7ok4uw	1213	18	occurs	occur	VBZ
cord-001835-0s7ok4uw	1213	19	in	in	IN
cord-001835-0s7ok4uw	1213	20	a	a	DT
cord-001835-0s7ok4uw	1213	21	co	co	JJ
cord-001835-0s7ok4uw	1213	22	-	-	JJ
cord-001835-0s7ok4uw	1213	23	translational	translational	JJ
cord-001835-0s7ok4uw	1213	24	manner	manner	NN
cord-001835-0s7ok4uw	1213	25	as	as	IN
cord-001835-0s7ok4uw	1213	26	the	the	DT
cord-001835-0s7ok4uw	1213	27	nascent	nascent	JJ
cord-001835-0s7ok4uw	1213	28	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	1213	29	chain	chain	NN
cord-001835-0s7ok4uw	1213	30	emerges	emerge	VBZ
cord-001835-0s7ok4uw	1213	31	from	from	IN
cord-001835-0s7ok4uw	1213	32	the	the	DT
cord-001835-0s7ok4uw	1213	33	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1213	34	's	's	POS
cord-001835-0s7ok4uw	1213	35	exit	exit	NN
cord-001835-0s7ok4uw	1213	36	tunnel	tunnel	NN
cord-001835-0s7ok4uw	1213	37	.	.	.
cord-001835-0s7ok4uw	1214	1	This	this	DT
cord-001835-0s7ok4uw	1214	2	study	study	NN
cord-001835-0s7ok4uw	1214	3	aims	aim	VBZ
cord-001835-0s7ok4uw	1214	4	to	to	TO
cord-001835-0s7ok4uw	1214	5	develop	develop	VB
cord-001835-0s7ok4uw	1214	6	the	the	DT
cord-001835-0s7ok4uw	1214	7	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	1214	8	and	and	CC
cord-001835-0s7ok4uw	1214	9	NMR	NMR	NNP
cord-001835-0s7ok4uw	1214	10	structural	structural	JJ
cord-001835-0s7ok4uw	1214	11	strategies	strategy	NNS
cord-001835-0s7ok4uw	1214	12	to	to	TO
cord-001835-0s7ok4uw	1214	13	characterize	characterize	VB
cord-001835-0s7ok4uw	1214	14	the	the	DT
cord-001835-0s7ok4uw	1214	15	co	co	JJ
cord-001835-0s7ok4uw	1214	16	-	-	JJ
cord-001835-0s7ok4uw	1214	17	translational	translational	JJ
cord-001835-0s7ok4uw	1214	18	folding	folding	NN
cord-001835-0s7ok4uw	1214	19	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	1214	20	of	of	IN
cord-001835-0s7ok4uw	1214	21	AAT	AAT	NNP
cord-001835-0s7ok4uw	1214	22	as	as	IN
cord-001835-0s7ok4uw	1214	23	it	-PRON-	PRP
cord-001835-0s7ok4uw	1214	24	is	be	VBZ
cord-001835-0s7ok4uw	1214	25	being	be	VBG
cord-001835-0s7ok4uw	1214	26	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	1214	27	on	on	IN
cord-001835-0s7ok4uw	1214	28	the	the	DT
cord-001835-0s7ok4uw	1214	29	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1214	30	.	.	.
cord-001835-0s7ok4uw	1215	1	For	for	IN
cord-001835-0s7ok4uw	1215	2	these	these	DT
cord-001835-0s7ok4uw	1215	3	studies	study	NNS
cord-001835-0s7ok4uw	1215	4	,	,	,
cord-001835-0s7ok4uw	1215	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1215	6	have	have	VBP
cord-001835-0s7ok4uw	1215	7	designed	design	VBN
cord-001835-0s7ok4uw	1215	8	a	a	DT
cord-001835-0s7ok4uw	1215	9	series	series	NN
cord-001835-0s7ok4uw	1215	10	of	of	IN
cord-001835-0s7ok4uw	1215	11	SecM	SecM	NNP
cord-001835-0s7ok4uw	1215	12	-	-	HYPH
cord-001835-0s7ok4uw	1215	13	stalled	stall	VBN
cord-001835-0s7ok4uw	1215	14	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1215	15	nascent	nascent	JJ
cord-001835-0s7ok4uw	1215	16	chain	chain	NN
cord-001835-0s7ok4uw	1215	17	complexes	complex	NNS
cord-001835-0s7ok4uw	1215	18	(	(	-LRB-
cord-001835-0s7ok4uw	1215	19	RNC	RNC	NNP
cord-001835-0s7ok4uw	1215	20	)	)	-RRB-
cord-001835-0s7ok4uw	1215	21	of	of	IN
cord-001835-0s7ok4uw	1215	22	AAT	AAT	NNP
cord-001835-0s7ok4uw	1215	23	of	of	IN
cord-001835-0s7ok4uw	1215	24	different	different	JJ
cord-001835-0s7ok4uw	1215	25	lengths	length	NNS
cord-001835-0s7ok4uw	1215	26	,	,	,
cord-001835-0s7ok4uw	1215	27	which	which	WDT
cord-001835-0s7ok4uw	1215	28	mimics	mimic	VBZ
cord-001835-0s7ok4uw	1215	29	the	the	DT
cord-001835-0s7ok4uw	1215	30	"	"	``
cord-001835-0s7ok4uw	1215	31	snapshots	snapshot	NNS
cord-001835-0s7ok4uw	1215	32	"	"	''
cord-001835-0s7ok4uw	1215	33	of	of	IN
cord-001835-0s7ok4uw	1215	34	the	the	DT
cord-001835-0s7ok4uw	1215	35	protein	protein	NN
cord-001835-0s7ok4uw	1215	36	synthesis	synthesis	NN
cord-001835-0s7ok4uw	1215	37	,	,	,
cord-001835-0s7ok4uw	1215	38	capturing	capture	VBG
cord-001835-0s7ok4uw	1215	39	the	the	DT
cord-001835-0s7ok4uw	1215	40	folding	folding	NN
cord-001835-0s7ok4uw	1215	41	process	process	NN
cord-001835-0s7ok4uw	1215	42	of	of	IN
cord-001835-0s7ok4uw	1215	43	the	the	DT
cord-001835-0s7ok4uw	1215	44	nascent	nascent	JJ
cord-001835-0s7ok4uw	1215	45	chain	chain	NN
cord-001835-0s7ok4uw	1215	46	during	during	IN
cord-001835-0s7ok4uw	1215	47	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1215	48	emergence	emergence	NN
cord-001835-0s7ok4uw	1215	49	from	from	IN
cord-001835-0s7ok4uw	1215	50	the	the	DT
cord-001835-0s7ok4uw	1215	51	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1215	52	.	.	.
cord-001835-0s7ok4uw	1216	1	Using	use	VBG
cord-001835-0s7ok4uw	1216	2	this	this	DT
cord-001835-0s7ok4uw	1216	3	library	library	NN
cord-001835-0s7ok4uw	1216	4	,	,	,
cord-001835-0s7ok4uw	1216	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1216	6	have	have	VBP
cord-001835-0s7ok4uw	1216	7	recently	recently	RB
cord-001835-0s7ok4uw	1216	8	developed	develop	VBN
cord-001835-0s7ok4uw	1216	9	a	a	DT
cord-001835-0s7ok4uw	1216	10	strategy	strategy	NN
cord-001835-0s7ok4uw	1216	11	to	to	TO
cord-001835-0s7ok4uw	1216	12	produce	produce	VB
cord-001835-0s7ok4uw	1216	13	large	large	JJ
cord-001835-0s7ok4uw	1216	14	quantities	quantity	NNS
cord-001835-0s7ok4uw	1216	15	of	of	IN
cord-001835-0s7ok4uw	1216	16	the	the	DT
cord-001835-0s7ok4uw	1216	17	RNCs	rnc	NNS
cord-001835-0s7ok4uw	1216	18	both	both	CC
cord-001835-0s7ok4uw	1216	19	in	in	IN
cord-001835-0s7ok4uw	1216	20	vitro	vitro	FW
cord-001835-0s7ok4uw	1216	21	and	and	CC
cord-001835-0s7ok4uw	1216	22	in	in	IN
cord-001835-0s7ok4uw	1216	23	vivo	vivo	NN
cord-001835-0s7ok4uw	1216	24	within	within	IN
cord-001835-0s7ok4uw	1216	25	E.	E.	NNP
cord-001835-0s7ok4uw	1216	26	coli	coli	NNS
cord-001835-0s7ok4uw	1216	27	,	,	,
cord-001835-0s7ok4uw	1216	28	a	a	DT
cord-001835-0s7ok4uw	1216	29	prerequisite	prerequisite	NN
cord-001835-0s7ok4uw	1216	30	for	for	IN
cord-001835-0s7ok4uw	1216	31	detailed	detailed	JJ
cord-001835-0s7ok4uw	1216	32	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	1216	33	and	and	CC
cord-001835-0s7ok4uw	1216	34	structural	structural	JJ
cord-001835-0s7ok4uw	1216	35	studies	study	NNS
cord-001835-0s7ok4uw	1216	36	.	.	.
cord-001835-0s7ok4uw	1217	1	Using	use	VBG
cord-001835-0s7ok4uw	1217	2	the	the	DT
cord-001835-0s7ok4uw	1217	3	AAT	AAT	NNP
cord-001835-0s7ok4uw	1217	4	-	-	HYPH
cord-001835-0s7ok4uw	1217	5	RNCs	rnc	NNS
cord-001835-0s7ok4uw	1217	6	,	,	,
cord-001835-0s7ok4uw	1217	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	1217	8	are	be	VBP
cord-001835-0s7ok4uw	1217	9	developing	develop	VBG
cord-001835-0s7ok4uw	1217	10	a	a	DT
cord-001835-0s7ok4uw	1217	11	suite	suite	NN
cord-001835-0s7ok4uw	1217	12	of	of	IN
cord-001835-0s7ok4uw	1217	13	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	1217	14	strategies	strategy	NNS
cord-001835-0s7ok4uw	1217	15	to	to	TO
cord-001835-0s7ok4uw	1217	16	probe	probe	VB
cord-001835-0s7ok4uw	1217	17	the	the	DT
cord-001835-0s7ok4uw	1217	18	capacity	capacity	NN
cord-001835-0s7ok4uw	1217	19	for	for	IN
cord-001835-0s7ok4uw	1217	20	AAT	AAT	NNP
cord-001835-0s7ok4uw	1217	21	nascent	nascent	JJ
cord-001835-0s7ok4uw	1217	22	chains	chain	NNS
cord-001835-0s7ok4uw	1217	23	to	to	TO
cord-001835-0s7ok4uw	1217	24	adopt	adopt	VB
cord-001835-0s7ok4uw	1217	25	native	native	JJ
cord-001835-0s7ok4uw	1217	26	structure	structure	NN
cord-001835-0s7ok4uw	1217	27	on	on	IN
cord-001835-0s7ok4uw	1217	28	the	the	DT
cord-001835-0s7ok4uw	1217	29	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1217	30	.	.	.
cord-001835-0s7ok4uw	1218	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1218	2	have	have	VBP
cord-001835-0s7ok4uw	1218	3	combined	combine	VBN
cord-001835-0s7ok4uw	1218	4	protease	protease	NN
cord-001835-0s7ok4uw	1218	5	inhibition	inhibition	NN
cord-001835-0s7ok4uw	1218	6	assays	assay	NNS
cord-001835-0s7ok4uw	1218	7	,	,	,
cord-001835-0s7ok4uw	1218	8	Western	western	JJ
cord-001835-0s7ok4uw	1218	9	blot	blot	NN
cord-001835-0s7ok4uw	1218	10	and	and	CC
cord-001835-0s7ok4uw	1218	11	native	native	JJ
cord-001835-0s7ok4uw	1218	12	-	-	HYPH
cord-001835-0s7ok4uw	1218	13	PAGE	page	NN
cord-001835-0s7ok4uw	1218	14	analysis	analysis	NN
cord-001835-0s7ok4uw	1218	15	to	to	TO
cord-001835-0s7ok4uw	1218	16	demonstrate	demonstrate	VB
cord-001835-0s7ok4uw	1218	17	that	that	IN
cord-001835-0s7ok4uw	1218	18	AAT	AAT	NNP
cord-001835-0s7ok4uw	1218	19	can	can	MD
cord-001835-0s7ok4uw	1218	20	fold	fold	VB
cord-001835-0s7ok4uw	1218	21	while	while	IN
cord-001835-0s7ok4uw	1218	22	bound	bind	VBN
cord-001835-0s7ok4uw	1218	23	to	to	IN
cord-001835-0s7ok4uw	1218	24	the	the	DT
cord-001835-0s7ok4uw	1218	25	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1218	26	.	.	.
cord-001835-0s7ok4uw	1219	1	In	in	IN
cord-001835-0s7ok4uw	1219	2	addition	addition	NN
cord-001835-0s7ok4uw	1219	3	,	,	,
cord-001835-0s7ok4uw	1219	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	1219	5	have	have	VBP
cord-001835-0s7ok4uw	1219	6	employed	employ	VBN
cord-001835-0s7ok4uw	1219	7	a	a	DT
cord-001835-0s7ok4uw	1219	8	cysteine	cysteine	NN
cord-001835-0s7ok4uw	1219	9	-	-	HYPH
cord-001835-0s7ok4uw	1219	10	based	base	VBN
cord-001835-0s7ok4uw	1219	11	modification	modification	NN
cord-001835-0s7ok4uw	1219	12	"	"	``
cord-001835-0s7ok4uw	1219	13	PEGylation	pegylation	NN
cord-001835-0s7ok4uw	1219	14	"	"	''
cord-001835-0s7ok4uw	1219	15	assay	assay	NN
cord-001835-0s7ok4uw	1219	16	to	to	TO
cord-001835-0s7ok4uw	1219	17	probe	probe	VB
cord-001835-0s7ok4uw	1219	18	lowresolution	lowresolution	NN
cord-001835-0s7ok4uw	1219	19	structural	structural	JJ
cord-001835-0s7ok4uw	1219	20	information	information	NN
cord-001835-0s7ok4uw	1219	21	of	of	IN
cord-001835-0s7ok4uw	1219	22	AAT	AAT	NNP
cord-001835-0s7ok4uw	1219	23	-	-	HYPH
cord-001835-0s7ok4uw	1219	24	RNC	RNC	NNP
cord-001835-0s7ok4uw	1219	25	and	and	CC
cord-001835-0s7ok4uw	1219	26	this	this	DT
cord-001835-0s7ok4uw	1219	27	will	will	MD
cord-001835-0s7ok4uw	1219	28	guide	guide	VB
cord-001835-0s7ok4uw	1219	29	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1219	30	structural	structural	JJ
cord-001835-0s7ok4uw	1219	31	studies	study	NNS
cord-001835-0s7ok4uw	1219	32	by	by	IN
cord-001835-0s7ok4uw	1219	33	NMR	NMR	NNP
cord-001835-0s7ok4uw	1219	34	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1219	35	to	to	TO
cord-001835-0s7ok4uw	1219	36	provide	provide	VB
cord-001835-0s7ok4uw	1219	37	a	a	DT
cord-001835-0s7ok4uw	1219	38	detailed	detailed	JJ
cord-001835-0s7ok4uw	1219	39	understanding	understanding	NN
cord-001835-0s7ok4uw	1219	40	of	of	IN
cord-001835-0s7ok4uw	1219	41	AAT	AAT	NNP
cord-001835-0s7ok4uw	1219	42	folding	fold	VBG
cord-001835-0s7ok4uw	1219	43	on	on	IN
cord-001835-0s7ok4uw	1219	44	the	the	DT
cord-001835-0s7ok4uw	1219	45	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1219	46	at	at	IN
cord-001835-0s7ok4uw	1219	47	high	high	JJ
cord-001835-0s7ok4uw	1219	48	resolution	resolution	NN
cord-001835-0s7ok4uw	1219	49	.	.	.
cord-001835-0s7ok4uw	1220	1	Thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1220	2	properties	property	NNS
cord-001835-0s7ok4uw	1220	3	of	of	IN
cord-001835-0s7ok4uw	1220	4	proteins	protein	NNS
cord-001835-0s7ok4uw	1220	5	vary	vary	VBP
cord-001835-0s7ok4uw	1220	6	with	with	IN
cord-001835-0s7ok4uw	1220	7	the	the	DT
cord-001835-0s7ok4uw	1220	8	environmental	environmental	JJ
cord-001835-0s7ok4uw	1220	9	solvent	solvent	NN
cord-001835-0s7ok4uw	1220	10	condition	condition	NN
cord-001835-0s7ok4uw	1220	11	(	(	-LRB-
cord-001835-0s7ok4uw	1220	12	temperature	temperature	NN
cord-001835-0s7ok4uw	1220	13	,	,	,
cord-001835-0s7ok4uw	1220	14	ions	ion	NNS
cord-001835-0s7ok4uw	1220	15	,	,	,
cord-001835-0s7ok4uw	1220	16	pH	pH	NNP
cord-001835-0s7ok4uw	1220	17	,	,	,
cord-001835-0s7ok4uw	1220	18	denaturants	denaturant	NNS
cord-001835-0s7ok4uw	1220	19	,	,	,
cord-001835-0s7ok4uw	1220	20	etc	etc	FW
cord-001835-0s7ok4uw	1220	21	.	.	.
cord-001835-0s7ok4uw	1220	22	)	)	-RRB-
cord-001835-0s7ok4uw	1220	23	.	.	.
cord-001835-0s7ok4uw	1221	1	Although	although	IN
cord-001835-0s7ok4uw	1221	2	the	the	DT
cord-001835-0s7ok4uw	1221	3	effect	effect	NN
cord-001835-0s7ok4uw	1221	4	of	of	IN
cord-001835-0s7ok4uw	1221	5	each	each	DT
cord-001835-0s7ok4uw	1221	6	environmental	environmental	JJ
cord-001835-0s7ok4uw	1221	7	factor	factor	NN
cord-001835-0s7ok4uw	1221	8	on	on	IN
cord-001835-0s7ok4uw	1221	9	proteins	protein	NNS
cord-001835-0s7ok4uw	1221	10	has	have	VBZ
cord-001835-0s7ok4uw	1221	11	been	be	VBN
cord-001835-0s7ok4uw	1221	12	well	well	RB
cord-001835-0s7ok4uw	1221	13	studied	study	VBN
cord-001835-0s7ok4uw	1221	14	,	,	,
cord-001835-0s7ok4uw	1221	15	the	the	DT
cord-001835-0s7ok4uw	1221	16	complex	complex	JJ
cord-001835-0s7ok4uw	1221	17	effect	effect	NN
cord-001835-0s7ok4uw	1221	18	of	of	IN
cord-001835-0s7ok4uw	1221	19	more	more	JJR
cord-001835-0s7ok4uw	1221	20	than	than	IN
cord-001835-0s7ok4uw	1221	21	two	two	CD
cord-001835-0s7ok4uw	1221	22	environmental	environmental	JJ
cord-001835-0s7ok4uw	1221	23	factors	factor	NNS
cord-001835-0s7ok4uw	1221	24	was	be	VBD
cord-001835-0s7ok4uw	1221	25	not	not	RB
cord-001835-0s7ok4uw	1221	26	studied	study	VBN
cord-001835-0s7ok4uw	1221	27	thoroughly	thoroughly	RB
cord-001835-0s7ok4uw	1221	28	.	.	.
cord-001835-0s7ok4uw	1222	1	In	in	IN
cord-001835-0s7ok4uw	1222	2	this	this	DT
cord-001835-0s7ok4uw	1222	3	study	study	NN
cord-001835-0s7ok4uw	1222	4	,	,	,
cord-001835-0s7ok4uw	1222	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1222	6	investigate	investigate	VBP
cord-001835-0s7ok4uw	1222	7	the	the	DT
cord-001835-0s7ok4uw	1222	8	simultaneous	simultaneous	JJ
cord-001835-0s7ok4uw	1222	9	effect	effect	NN
cord-001835-0s7ok4uw	1222	10	of	of	IN
cord-001835-0s7ok4uw	1222	11	urea	urea	NN
cord-001835-0s7ok4uw	1222	12	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1222	13	(	(	-LRB-
cord-001835-0s7ok4uw	1222	14	disruption	disruption	NN
cord-001835-0s7ok4uw	1222	15	of	of	IN
cord-001835-0s7ok4uw	1222	16	non	non	JJ
cord-001835-0s7ok4uw	1222	17	-	-	JJ
cord-001835-0s7ok4uw	1222	18	covalent	covalent	JJ
cord-001835-0s7ok4uw	1222	19	bonds	bond	NNS
cord-001835-0s7ok4uw	1222	20	in	in	IN
cord-001835-0s7ok4uw	1222	21	proteins	protein	NNS
cord-001835-0s7ok4uw	1222	22	)	)	-RRB-
cord-001835-0s7ok4uw	1222	23	and	and	CC
cord-001835-0s7ok4uw	1222	24	acid	acid	NN
cord-001835-0s7ok4uw	1222	25	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1222	26	(	(	-LRB-
cord-001835-0s7ok4uw	1222	27	titration	titration	NN
cord-001835-0s7ok4uw	1222	28	of	of	IN
cord-001835-0s7ok4uw	1222	29	protein	protein	NN
cord-001835-0s7ok4uw	1222	30	residues	residue	NNS
cord-001835-0s7ok4uw	1222	31	)	)	-RRB-
cord-001835-0s7ok4uw	1222	32	on	on	IN
cord-001835-0s7ok4uw	1222	33	the	the	DT
cord-001835-0s7ok4uw	1222	34	nature	nature	NN
cord-001835-0s7ok4uw	1222	35	of	of	IN
cord-001835-0s7ok4uw	1222	36	the	the	DT
cord-001835-0s7ok4uw	1222	37	folding	folding	NN
cord-001835-0s7ok4uw	1222	38	transition	transition	NN
cord-001835-0s7ok4uw	1222	39	for	for	IN
cord-001835-0s7ok4uw	1222	40	2CYU	2cyu	JJ
cord-001835-0s7ok4uw	1222	41	protein	protein	NN
cord-001835-0s7ok4uw	1222	42	.	.	.
cord-001835-0s7ok4uw	1223	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1223	2	performed	perform	VBD
cord-001835-0s7ok4uw	1223	3	the	the	DT
cord-001835-0s7ok4uw	1223	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	1223	5	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1223	6	simulations	simulation	NNS
cord-001835-0s7ok4uw	1223	7	of	of	IN
cord-001835-0s7ok4uw	1223	8	BBL	BBL	NNP
cord-001835-0s7ok4uw	1223	9	(	(	-LRB-
cord-001835-0s7ok4uw	1223	10	PDB	PDB	NNP
cord-001835-0s7ok4uw	1223	11	code	code	NN
cord-001835-0s7ok4uw	1223	12	:	:	:
cord-001835-0s7ok4uw	1224	1	2CYU	2CYU	NNP
cord-001835-0s7ok4uw	1224	2	)	)	-RRB-
cord-001835-0s7ok4uw	1224	3	protein	protein	NN
cord-001835-0s7ok4uw	1224	4	in	in	IN
cord-001835-0s7ok4uw	1224	5	various	various	JJ
cord-001835-0s7ok4uw	1224	6	urea	urea	NN
cord-001835-0s7ok4uw	1224	7	concentration	concentration	NN
cord-001835-0s7ok4uw	1224	8	at	at	IN
cord-001835-0s7ok4uw	1224	9	300K.	300K.	NNP
cord-001835-0s7ok4uw	1225	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1225	2	calculated	calculate	VBD
cord-001835-0s7ok4uw	1225	3	pH	ph	NN
cord-001835-0s7ok4uw	1225	4	-	-	HYPH
cord-001835-0s7ok4uw	1225	5	dependent	dependent	JJ
cord-001835-0s7ok4uw	1225	6	free	free	JJ
cord-001835-0s7ok4uw	1225	7	energy	energy	NN
cord-001835-0s7ok4uw	1225	8	landscape	landscape	NN
cord-001835-0s7ok4uw	1225	9	using	use	VBG
cord-001835-0s7ok4uw	1225	10	the	the	DT
cord-001835-0s7ok4uw	1225	11	extended	extended	JJ
cord-001835-0s7ok4uw	1225	12	Munoz	Munoz	NNP
cord-001835-0s7ok4uw	1225	13	-	-	HYPH
cord-001835-0s7ok4uw	1225	14	Eaton	Eaton	NNP
cord-001835-0s7ok4uw	1225	15	model	model	NN
cord-001835-0s7ok4uw	1225	16	and	and	CC
cord-001835-0s7ok4uw	1225	17	described	describe	VBD
cord-001835-0s7ok4uw	1225	18	the	the	DT
cord-001835-0s7ok4uw	1225	19	phase	phase	NN
cord-001835-0s7ok4uw	1225	20	diagram	diagram	NN
cord-001835-0s7ok4uw	1225	21	for	for	IN
cord-001835-0s7ok4uw	1225	22	the	the	DT
cord-001835-0s7ok4uw	1225	23	folding	folding	NN
cord-001835-0s7ok4uw	1225	24	transition	transition	NN
cord-001835-0s7ok4uw	1225	25	of	of	IN
cord-001835-0s7ok4uw	1225	26	BBL	bbl	NN
cord-001835-0s7ok4uw	1225	27	at	at	IN
cord-001835-0s7ok4uw	1225	28	various	various	JJ
cord-001835-0s7ok4uw	1225	29	pH	ph	NN
cord-001835-0s7ok4uw	1225	30	value	value	NN
cord-001835-0s7ok4uw	1225	31	and	and	CC
cord-001835-0s7ok4uw	1225	32	urea	urea	NN
cord-001835-0s7ok4uw	1225	33	concentration	concentration	NN
cord-001835-0s7ok4uw	1225	34	.	.	.
cord-001835-0s7ok4uw	1226	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1226	2	mapped	map	VBD
cord-001835-0s7ok4uw	1226	3	out	out	RP
cord-001835-0s7ok4uw	1226	4	the	the	DT
cord-001835-0s7ok4uw	1226	5	phase	phase	NN
cord-001835-0s7ok4uw	1226	6	diagram	diagram	NN
cord-001835-0s7ok4uw	1226	7	of	of	IN
cord-001835-0s7ok4uw	1226	8	the	the	DT
cord-001835-0s7ok4uw	1226	9	folding	folding	NN
cord-001835-0s7ok4uw	1226	10	transition	transition	NN
cord-001835-0s7ok4uw	1226	11	of	of	IN
cord-001835-0s7ok4uw	1226	12	2CYU	2cyu	CD
cord-001835-0s7ok4uw	1226	13	,	,	,
cord-001835-0s7ok4uw	1226	14	which	which	WDT
cord-001835-0s7ok4uw	1226	15	clarifies	clarify	VBZ
cord-001835-0s7ok4uw	1226	16	the	the	DT
cord-001835-0s7ok4uw	1226	17	condition	condition	NN
cord-001835-0s7ok4uw	1226	18	with	with	IN
cord-001835-0s7ok4uw	1226	19	which	which	WDT
cord-001835-0s7ok4uw	1226	20	it	-PRON-	PRP
cord-001835-0s7ok4uw	1226	21	undergoes	undergo	VBZ
cord-001835-0s7ok4uw	1226	22	the	the	DT
cord-001835-0s7ok4uw	1226	23	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	1226	24	folding	folding	NN
cord-001835-0s7ok4uw	1226	25	transition	transition	NN
cord-001835-0s7ok4uw	1226	26	or	or	CC
cord-001835-0s7ok4uw	1226	27	the	the	DT
cord-001835-0s7ok4uw	1226	28	barrierless	barrierless	NN
cord-001835-0s7ok4uw	1226	29	folding	fold	VBG
cord-001835-0s7ok4uw	1226	30	transition	transition	NN
cord-001835-0s7ok4uw	1226	31	.	.	.
cord-001835-0s7ok4uw	1227	1	Biophysical	biophysical	JJ
cord-001835-0s7ok4uw	1227	2	analysis	analysis	NN
cord-001835-0s7ok4uw	1227	3	of	of	IN
cord-001835-0s7ok4uw	1227	4	partially	partially	RB
cord-001835-0s7ok4uw	1227	5	folded	fold	VBN
cord-001835-0s7ok4uw	1227	6	states	state	NNS
cord-001835-0s7ok4uw	1227	7	of	of	IN
cord-001835-0s7ok4uw	1227	8	myoglobin	myoglobin	NN
cord-001835-0s7ok4uw	1227	9	in	in	IN
cord-001835-0s7ok4uw	1227	10	presence	presence	NN
cord-001835-0s7ok4uw	1227	11	of	of	IN
cord-001835-0s7ok4uw	1227	12	2,2,2-trifluoroethanol	2,2,2-trifluoroethanol	CD
cord-001835-0s7ok4uw	1227	13	Paurnima	Paurnima	NNP
cord-001835-0s7ok4uw	1227	14	Talele	Talele	NNP
cord-001835-0s7ok4uw	1227	15	1	1	CD
cord-001835-0s7ok4uw	1227	16	,	,	,
cord-001835-0s7ok4uw	1227	17	Nand	Nand	NNP
cord-001835-0s7ok4uw	1227	18	Kishore	Kishore	NNP
cord-001835-0s7ok4uw	1227	19	1	1	CD
cord-001835-0s7ok4uw	1227	20	1	1	CD
cord-001835-0s7ok4uw	1228	1	The	the	DT
cord-001835-0s7ok4uw	1228	2	protein	protein	NN
cord-001835-0s7ok4uw	1228	3	folding	folding	NN
cord-001835-0s7ok4uw	1228	4	process	process	NN
cord-001835-0s7ok4uw	1228	5	involves	involve	VBZ
cord-001835-0s7ok4uw	1228	6	one	one	CD
cord-001835-0s7ok4uw	1228	7	or	or	CC
cord-001835-0s7ok4uw	1228	8	more	more	RBR
cord-001835-0s7ok4uw	1228	9	distinct	distinct	JJ
cord-001835-0s7ok4uw	1228	10	populated	populated	JJ
cord-001835-0s7ok4uw	1228	11	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	1228	12	.	.	.
cord-001835-0s7ok4uw	1229	1	One	one	CD
cord-001835-0s7ok4uw	1229	2	such	such	JJ
cord-001835-0s7ok4uw	1229	3	partially	partially	RB
cord-001835-0s7ok4uw	1229	4	folded	fold	VBN
cord-001835-0s7ok4uw	1229	5	structure	structure	NN
cord-001835-0s7ok4uw	1229	6	of	of	IN
cord-001835-0s7ok4uw	1229	7	particular	particular	JJ
cord-001835-0s7ok4uw	1229	8	importance	importance	NN
cord-001835-0s7ok4uw	1229	9	observed	observe	VBN
cord-001835-0s7ok4uw	1229	10	during	during	IN
cord-001835-0s7ok4uw	1229	11	protein	protein	NN
cord-001835-0s7ok4uw	1229	12	folding	folding	NN
cord-001835-0s7ok4uw	1229	13	pathway	pathway	NN
cord-001835-0s7ok4uw	1229	14	is	be	VBZ
cord-001835-0s7ok4uw	1229	15	molten	molten	JJ
cord-001835-0s7ok4uw	1229	16	globule	globule	NN
cord-001835-0s7ok4uw	1229	17	state	state	NN
cord-001835-0s7ok4uw	1229	18	.	.	.
cord-001835-0s7ok4uw	1230	1	The	the	DT
cord-001835-0s7ok4uw	1230	2	properties	property	NNS
cord-001835-0s7ok4uw	1230	3	of	of	IN
cord-001835-0s7ok4uw	1230	4	a	a	DT
cord-001835-0s7ok4uw	1230	5	molten	molten	JJ
cord-001835-0s7ok4uw	1230	6	globule	globule	NN
cord-001835-0s7ok4uw	1230	7	state	state	NN
cord-001835-0s7ok4uw	1230	8	are	be	VBP
cord-001835-0s7ok4uw	1230	9	intermediate	intermediate	JJ
cord-001835-0s7ok4uw	1230	10	between	between	IN
cord-001835-0s7ok4uw	1230	11	those	those	DT
cord-001835-0s7ok4uw	1230	12	of	of	IN
cord-001835-0s7ok4uw	1230	13	native	native	JJ
cord-001835-0s7ok4uw	1230	14	and	and	CC
cord-001835-0s7ok4uw	1230	15	unfolded	unfolded	JJ
cord-001835-0s7ok4uw	1230	16	protein	protein	NN
cord-001835-0s7ok4uw	1230	17	molecules	molecule	NNS
cord-001835-0s7ok4uw	1230	18	.	.	.
cord-001835-0s7ok4uw	1231	1	The	the	DT
cord-001835-0s7ok4uw	1231	2	importance	importance	NN
cord-001835-0s7ok4uw	1231	3	of	of	IN
cord-001835-0s7ok4uw	1231	4	studying	study	VBG
cord-001835-0s7ok4uw	1231	5	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	1231	6	molten	molten	JJ
cord-001835-0s7ok4uw	1231	7	globule	globule	NN
cord-001835-0s7ok4uw	1231	8	is	be	VBZ
cord-001835-0s7ok4uw	1231	9	in	in	IN
cord-001835-0s7ok4uw	1231	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1231	11	greater	great	JJR
cord-001835-0s7ok4uw	1231	12	stability	stability	NN
cord-001835-0s7ok4uw	1231	13	and	and	CC
cord-001835-0s7ok4uw	1231	14	flexible	flexible	JJ
cord-001835-0s7ok4uw	1231	15	structure	structure	NN
cord-001835-0s7ok4uw	1231	16	which	which	WDT
cord-001835-0s7ok4uw	1231	17	has	have	VBZ
cord-001835-0s7ok4uw	1231	18	been	be	VBN
cord-001835-0s7ok4uw	1231	19	shown	show	VBN
cord-001835-0s7ok4uw	1231	20	to	to	TO
cord-001835-0s7ok4uw	1231	21	bind	bind	VB
cord-001835-0s7ok4uw	1231	22	a	a	DT
cord-001835-0s7ok4uw	1231	23	variety	variety	NN
cord-001835-0s7ok4uw	1231	24	of	of	IN
cord-001835-0s7ok4uw	1231	25	substrates	substrate	NNS
cord-001835-0s7ok4uw	1231	26	and	and	CC
cord-001835-0s7ok4uw	1231	27	play	play	VB
cord-001835-0s7ok4uw	1231	28	a	a	DT
cord-001835-0s7ok4uw	1231	29	definite	definite	JJ
cord-001835-0s7ok4uw	1231	30	role	role	NN
cord-001835-0s7ok4uw	1231	31	in	in	IN
cord-001835-0s7ok4uw	1231	32	certain	certain	JJ
cord-001835-0s7ok4uw	1231	33	human	human	JJ
cord-001835-0s7ok4uw	1231	34	diseases	disease	NNS
cord-001835-0s7ok4uw	1231	35	via	via	IN
cord-001835-0s7ok4uw	1231	36	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1231	37	,	,	,
cord-001835-0s7ok4uw	1231	38	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	1231	39	or	or	CC
cord-001835-0s7ok4uw	1231	40	some	some	DT
cord-001835-0s7ok4uw	1231	41	other	other	JJ
cord-001835-0s7ok4uw	1231	42	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1231	43	.	.	.
cord-001835-0s7ok4uw	1232	1	A	a	DT
cord-001835-0s7ok4uw	1232	2	protein	protein	NN
cord-001835-0s7ok4uw	1232	3	must	must	MD
cord-001835-0s7ok4uw	1232	4	assume	assume	VB
cord-001835-0s7ok4uw	1232	5	a	a	DT
cord-001835-0s7ok4uw	1232	6	stable	stable	JJ
cord-001835-0s7ok4uw	1232	7	and	and	CC
cord-001835-0s7ok4uw	1232	8	precisely	precisely	RB
cord-001835-0s7ok4uw	1232	9	ordered	order	VBN
cord-001835-0s7ok4uw	1232	10	conformation	conformation	NN
cord-001835-0s7ok4uw	1232	11	to	to	TO
cord-001835-0s7ok4uw	1232	12	perform	perform	VB
cord-001835-0s7ok4uw	1232	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1232	14	biological	biological	JJ
cord-001835-0s7ok4uw	1232	15	function	function	NN
cord-001835-0s7ok4uw	1232	16	properly	properly	RB
cord-001835-0s7ok4uw	1232	17	.	.	.
cord-001835-0s7ok4uw	1233	1	The	the	DT
cord-001835-0s7ok4uw	1233	2	stability	stability	NN
cord-001835-0s7ok4uw	1233	3	of	of	IN
cord-001835-0s7ok4uw	1233	4	a	a	DT
cord-001835-0s7ok4uw	1233	5	protein	protein	NN
cord-001835-0s7ok4uw	1233	6	under	under	IN
cord-001835-0s7ok4uw	1233	7	specific	specific	JJ
cord-001835-0s7ok4uw	1233	8	conditions	condition	NNS
cord-001835-0s7ok4uw	1233	9	depends	depend	VBZ
cord-001835-0s7ok4uw	1233	10	on	on	IN
cord-001835-0s7ok4uw	1233	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1233	12	interactions	interaction	NNS
cord-001835-0s7ok4uw	1233	13	with	with	IN
cord-001835-0s7ok4uw	1233	14	the	the	DT
cord-001835-0s7ok4uw	1233	15	solvent	solvent	NN
cord-001835-0s7ok4uw	1233	16	environment	environment	NN
cord-001835-0s7ok4uw	1233	17	.	.	.
cord-001835-0s7ok4uw	1234	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	1234	2	it	-PRON-	PRP
cord-001835-0s7ok4uw	1234	3	is	be	VBZ
cord-001835-0s7ok4uw	1234	4	essential	essential	JJ
cord-001835-0s7ok4uw	1234	5	to	to	TO
cord-001835-0s7ok4uw	1234	6	understand	understand	VB
cord-001835-0s7ok4uw	1234	7	protein	protein	NN
cord-001835-0s7ok4uw	1234	8	folding	folding	NN
cord-001835-0s7ok4uw	1234	9	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	1234	10	,	,	,
cord-001835-0s7ok4uw	1234	11	protein	protein	NN
cord-001835-0s7ok4uw	1234	12	solvent	solvent	NN
cord-001835-0s7ok4uw	1234	13	interactions	interaction	NNS
cord-001835-0s7ok4uw	1234	14	and	and	CC
cord-001835-0s7ok4uw	1234	15	protein	protein	NN
cord-001835-0s7ok4uw	1234	16	stabilization	stabilization	NN
cord-001835-0s7ok4uw	1234	17	.	.	.
cord-001835-0s7ok4uw	1235	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1235	2	have	have	VBP
cord-001835-0s7ok4uw	1235	3	made	make	VBN
cord-001835-0s7ok4uw	1235	4	attempts	attempt	NNS
cord-001835-0s7ok4uw	1235	5	to	to	TO
cord-001835-0s7ok4uw	1235	6	thoroughly	thoroughly	RB
cord-001835-0s7ok4uw	1235	7	investigate	investigate	VB
cord-001835-0s7ok4uw	1235	8	the	the	DT
cord-001835-0s7ok4uw	1235	9	formation	formation	NN
cord-001835-0s7ok4uw	1235	10	of	of	IN
cord-001835-0s7ok4uw	1235	11	stable	stable	JJ
cord-001835-0s7ok4uw	1235	12	molten	molten	JJ
cord-001835-0s7ok4uw	1235	13	globule	globule	NN
cord-001835-0s7ok4uw	1235	14	state	state	NN
cord-001835-0s7ok4uw	1235	15	of	of	IN
cord-001835-0s7ok4uw	1235	16	the	the	DT
cord-001835-0s7ok4uw	1235	17	protein	protein	NN
cord-001835-0s7ok4uw	1235	18	induced	induce	VBN
cord-001835-0s7ok4uw	1235	19	by	by	IN
cord-001835-0s7ok4uw	1235	20	alcohol	alcohol	NN
cord-001835-0s7ok4uw	1235	21	using	use	VBG
cord-001835-0s7ok4uw	1235	22	combination	combination	NN
cord-001835-0s7ok4uw	1235	23	of	of	IN
cord-001835-0s7ok4uw	1235	24	calorimetric	calorimetric	JJ
cord-001835-0s7ok4uw	1235	25	and	and	CC
cord-001835-0s7ok4uw	1235	26	spectroscopic	spectroscopic	JJ
cord-001835-0s7ok4uw	1235	27	techniques	technique	NNS
cord-001835-0s7ok4uw	1235	28	.	.	.
cord-001835-0s7ok4uw	1236	1	The	the	DT
cord-001835-0s7ok4uw	1236	2	presentation	presentation	NN
cord-001835-0s7ok4uw	1236	3	will	will	MD
cord-001835-0s7ok4uw	1236	4	cover	cover	VB
cord-001835-0s7ok4uw	1236	5	the	the	DT
cord-001835-0s7ok4uw	1236	6	topic	topic	NN
cord-001835-0s7ok4uw	1236	7	on	on	IN
cord-001835-0s7ok4uw	1236	8	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	1236	9	studies	study	NNS
cord-001835-0s7ok4uw	1236	10	on	on	IN
cord-001835-0s7ok4uw	1236	11	partially	partially	RB
cord-001835-0s7ok4uw	1236	12	folded	fold	VBN
cord-001835-0s7ok4uw	1236	13	states	state	NNS
cord-001835-0s7ok4uw	1236	14	of	of	IN
cord-001835-0s7ok4uw	1236	15	myoglobin	myoglobin	NN
cord-001835-0s7ok4uw	1236	16	in	in	IN
cord-001835-0s7ok4uw	1236	17	presence	presence	NN
cord-001835-0s7ok4uw	1236	18	of	of	IN
cord-001835-0s7ok4uw	1236	19	2,2,2-trifluoroethanol	2,2,2-trifluoroethanol	CD
cord-001835-0s7ok4uw	1236	20	.	.	.
cord-001835-0s7ok4uw	1237	1	The	the	DT
cord-001835-0s7ok4uw	1237	2	thermal	thermal	JJ
cord-001835-0s7ok4uw	1237	3	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1237	4	of	of	IN
cord-001835-0s7ok4uw	1237	5	myoglobin	myoglobin	NN
cord-001835-0s7ok4uw	1237	6	was	be	VBD
cord-001835-0s7ok4uw	1237	7	studied	study	VBN
cord-001835-0s7ok4uw	1237	8	in	in	IN
cord-001835-0s7ok4uw	1237	9	the	the	DT
cord-001835-0s7ok4uw	1237	10	presence	presence	NN
cord-001835-0s7ok4uw	1237	11	of	of	IN
cord-001835-0s7ok4uw	1237	12	2,2,2-trifluoroethanol	2,2,2-trifluoroethanol	CD
cord-001835-0s7ok4uw	1237	13	(	(	-LRB-
cord-001835-0s7ok4uw	1237	14	TFE	TFE	NNP
cord-001835-0s7ok4uw	1237	15	)	)	-RRB-
cord-001835-0s7ok4uw	1237	16	at	at	IN
cord-001835-0s7ok4uw	1237	17	various	various	JJ
cord-001835-0s7ok4uw	1237	18	pH	ph	NN
cord-001835-0s7ok4uw	1237	19	values	value	NNS
cord-001835-0s7ok4uw	1237	20	using	use	VBG
cord-001835-0s7ok4uw	1237	21	differential	differential	JJ
cord-001835-0s7ok4uw	1237	22	scanning	scanning	NN
cord-001835-0s7ok4uw	1237	23	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	1237	24	and	and	CC
cord-001835-0s7ok4uw	1237	25	UV	uv	NN
cord-001835-0s7ok4uw	1237	26	-	-	HYPH
cord-001835-0s7ok4uw	1237	27	visible	visible	JJ
cord-001835-0s7ok4uw	1237	28	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1237	29	.	.	.
cord-001835-0s7ok4uw	1238	1	The	the	DT
cord-001835-0s7ok4uw	1238	2	most	most	RBS
cord-001835-0s7ok4uw	1238	3	obvious	obvious	JJ
cord-001835-0s7ok4uw	1238	4	effect	effect	NN
cord-001835-0s7ok4uw	1238	5	of	of	IN
cord-001835-0s7ok4uw	1238	6	TFE	TFE	NNP
cord-001835-0s7ok4uw	1238	7	was	be	VBD
cord-001835-0s7ok4uw	1238	8	lowering	lower	VBG
cord-001835-0s7ok4uw	1238	9	of	of	IN
cord-001835-0s7ok4uw	1238	10	the	the	DT
cord-001835-0s7ok4uw	1238	11	transition	transition	NN
cord-001835-0s7ok4uw	1238	12	temperature	temperature	NN
cord-001835-0s7ok4uw	1238	13	with	with	IN
cord-001835-0s7ok4uw	1238	14	increasing	increase	VBG
cord-001835-0s7ok4uw	1238	15	concentration	concentration	NN
cord-001835-0s7ok4uw	1238	16	of	of	IN
cord-001835-0s7ok4uw	1238	17	TFE	TFE	NNP
cord-001835-0s7ok4uw	1238	18	up	up	IN
cord-001835-0s7ok4uw	1238	19	to	to	IN
cord-001835-0s7ok4uw	1238	20	1.5	1.5	CD
cord-001835-0s7ok4uw	1238	21	mol•dm-3	mol•dm-3	NNP
cord-001835-0s7ok4uw	1238	22	,	,	,
cord-001835-0s7ok4uw	1238	23	beyond	beyond	IN
cord-001835-0s7ok4uw	1238	24	which	which	WDT
cord-001835-0s7ok4uw	1238	25	no	no	DT
cord-001835-0s7ok4uw	1238	26	thermal	thermal	JJ
cord-001835-0s7ok4uw	1238	27	transitions	transition	NNS
cord-001835-0s7ok4uw	1238	28	were	be	VBD
cord-001835-0s7ok4uw	1238	29	observed	observe	VBN
cord-001835-0s7ok4uw	1238	30	.	.	.
cord-001835-0s7ok4uw	1239	1	The	the	DT
cord-001835-0s7ok4uw	1239	2	conformation	conformation	NN
cord-001835-0s7ok4uw	1239	3	of	of	IN
cord-001835-0s7ok4uw	1239	4	the	the	DT
cord-001835-0s7ok4uw	1239	5	protein	protein	NN
cord-001835-0s7ok4uw	1239	6	was	be	VBD
cord-001835-0s7ok4uw	1239	7	analyzed	analyze	VBN
cord-001835-0s7ok4uw	1239	8	by	by	IN
cord-001835-0s7ok4uw	1239	9	a	a	DT
cord-001835-0s7ok4uw	1239	10	combination	combination	NN
cord-001835-0s7ok4uw	1239	11	of	of	IN
cord-001835-0s7ok4uw	1239	12	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1239	13	and	and	CC
cord-001835-0s7ok4uw	1239	14	circular	circular	JJ
cord-001835-0s7ok4uw	1239	15	dichroism	dichroism	NN
cord-001835-0s7ok4uw	1239	16	measurements	measurement	NNS
cord-001835-0s7ok4uw	1239	17	.	.	.
cord-001835-0s7ok4uw	1240	1	At	at	IN
cord-001835-0s7ok4uw	1240	2	pH	pH	NNP
cord-001835-0s7ok4uw	1240	3	5.0	5.0	CD
cord-001835-0s7ok4uw	1240	4	and	and	CC
cord-001835-0s7ok4uw	1240	5	11.0	11.0	CD
cord-001835-0s7ok4uw	1240	6	,	,	,
cord-001835-0s7ok4uw	1240	7	partially	partially	RB
cord-001835-0s7ok4uw	1240	8	folded	fold	VBD
cord-001835-0s7ok4uw	1240	9	states	state	NNS
cord-001835-0s7ok4uw	1240	10	of	of	IN
cord-001835-0s7ok4uw	1240	11	myoglobin	myoglobin	NN
cord-001835-0s7ok4uw	1240	12	were	be	VBD
cord-001835-0s7ok4uw	1240	13	confirmed	confirm	VBN
cord-001835-0s7ok4uw	1240	14	by	by	IN
cord-001835-0s7ok4uw	1240	15	CD	cd	NN
cord-001835-0s7ok4uw	1240	16	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1240	17	.	.	.
cord-001835-0s7ok4uw	1241	1	Quantitative	quantitative	JJ
cord-001835-0s7ok4uw	1241	2	binding	binding	NN
cord-001835-0s7ok4uw	1241	3	of	of	IN
cord-001835-0s7ok4uw	1241	4	ANS	an	NNS
cord-001835-0s7ok4uw	1241	5	to	to	IN
cord-001835-0s7ok4uw	1241	6	the	the	DT
cord-001835-0s7ok4uw	1241	7	TFE	TFE	NNP
cord-001835-0s7ok4uw	1241	8	induced	induce	VBD
cord-001835-0s7ok4uw	1241	9	molten	molten	JJ
cord-001835-0s7ok4uw	1241	10	globule	globule	NN
cord-001835-0s7ok4uw	1241	11	state	state	NN
cord-001835-0s7ok4uw	1241	12	of	of	IN
cord-001835-0s7ok4uw	1241	13	myoglobin	myoglobin	NN
cord-001835-0s7ok4uw	1241	14	was	be	VBD
cord-001835-0s7ok4uw	1241	15	studied	study	VBN
cord-001835-0s7ok4uw	1241	16	by	by	IN
cord-001835-0s7ok4uw	1241	17	using	use	VBG
cord-001835-0s7ok4uw	1241	18	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	1241	19	titration	titration	NN
cord-001835-0s7ok4uw	1241	20	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	1241	21	(	(	-LRB-
cord-001835-0s7ok4uw	1241	22	ITC	ITC	NNP
cord-001835-0s7ok4uw	1241	23	)	)	-RRB-
cord-001835-0s7ok4uw	1241	24	.	.	.
cord-001835-0s7ok4uw	1242	1	The	the	DT
cord-001835-0s7ok4uw	1242	2	results	result	NNS
cord-001835-0s7ok4uw	1242	3	enable	enable	VBP
cord-001835-0s7ok4uw	1242	4	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	1242	5	estimation	estimation	NN
cord-001835-0s7ok4uw	1242	6	of	of	IN
cord-001835-0s7ok4uw	1242	7	the	the	DT
cord-001835-0s7ok4uw	1242	8	binding	binding	NN
cord-001835-0s7ok4uw	1242	9	strength	strength	NN
cord-001835-0s7ok4uw	1242	10	of	of	IN
cord-001835-0s7ok4uw	1242	11	ANS	an	NNS
cord-001835-0s7ok4uw	1242	12	with	with	IN
cord-001835-0s7ok4uw	1242	13	the	the	DT
cord-001835-0s7ok4uw	1242	14	molten	molten	JJ
cord-001835-0s7ok4uw	1242	15	globule	globule	NN
cord-001835-0s7ok4uw	1242	16	state	state	NN
cord-001835-0s7ok4uw	1242	17	of	of	IN
cord-001835-0s7ok4uw	1242	18	myoglobin	myoglobin	NN
cord-001835-0s7ok4uw	1242	19	along	along	IN
cord-001835-0s7ok4uw	1242	20	with	with	IN
cord-001835-0s7ok4uw	1242	21	the	the	DT
cord-001835-0s7ok4uw	1242	22	enthalpic	enthalpic	JJ
cord-001835-0s7ok4uw	1242	23	and	and	CC
cord-001835-0s7ok4uw	1242	24	entropic	entropic	JJ
cord-001835-0s7ok4uw	1242	25	contributions	contribution	NNS
cord-001835-0s7ok4uw	1242	26	to	to	IN
cord-001835-0s7ok4uw	1242	27	the	the	DT
cord-001835-0s7ok4uw	1242	28	binding	binding	NN
cord-001835-0s7ok4uw	1242	29	process	process	NN
cord-001835-0s7ok4uw	1242	30	.	.	.
cord-001835-0s7ok4uw	1243	1	The	the	DT
cord-001835-0s7ok4uw	1243	2	results	result	NNS
cord-001835-0s7ok4uw	1243	3	also	also	RB
cord-001835-0s7ok4uw	1243	4	suggest	suggest	VBP
cord-001835-0s7ok4uw	1243	5	occurrence	occurrence	NN
cord-001835-0s7ok4uw	1243	6	of	of	IN
cord-001835-0s7ok4uw	1243	7	common	common	JJ
cord-001835-0s7ok4uw	1243	8	structural	structural	JJ
cord-001835-0s7ok4uw	1243	9	features	feature	NNS
cord-001835-0s7ok4uw	1243	10	of	of	IN
cord-001835-0s7ok4uw	1243	11	the	the	DT
cord-001835-0s7ok4uw	1243	12	molten	molten	JJ
cord-001835-0s7ok4uw	1243	13	globule	globule	NN
cord-001835-0s7ok4uw	1243	14	states	state	NNS
cord-001835-0s7ok4uw	1243	15	of	of	IN
cord-001835-0s7ok4uw	1243	16	proteins	protein	NNS
cord-001835-0s7ok4uw	1243	17	offering	offer	VBG
cord-001835-0s7ok4uw	1243	18	two	two	CD
cord-001835-0s7ok4uw	1243	19	types	type	NNS
cord-001835-0s7ok4uw	1243	20	of	of	IN
cord-001835-0s7ok4uw	1243	21	binding	bind	VBG
cord-001835-0s7ok4uw	1243	22	sites	site	NNS
cord-001835-0s7ok4uw	1243	23	to	to	IN
cord-001835-0s7ok4uw	1243	24	ANS	an	NNS
cord-001835-0s7ok4uw	1243	25	molecules	molecule	NNS
cord-001835-0s7ok4uw	1243	26	which	which	WDT
cord-001835-0s7ok4uw	1243	27	has	have	VBZ
cord-001835-0s7ok4uw	1243	28	been	be	VBN
cord-001835-0s7ok4uw	1243	29	widely	widely	RB
cord-001835-0s7ok4uw	1243	30	used	use	VBN
cord-001835-0s7ok4uw	1243	31	as	as	IN
cord-001835-0s7ok4uw	1243	32	a	a	DT
cord-001835-0s7ok4uw	1243	33	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1243	34	probe	probe	NN
cord-001835-0s7ok4uw	1243	35	to	to	TO
cord-001835-0s7ok4uw	1243	36	characterize	characterize	VB
cord-001835-0s7ok4uw	1243	37	partially	partially	RB
cord-001835-0s7ok4uw	1243	38	folded	fold	VBN
cord-001835-0s7ok4uw	1243	39	states	state	NNS
cord-001835-0s7ok4uw	1243	40	of	of	IN
cord-001835-0s7ok4uw	1243	41	proteins	protein	NNS
cord-001835-0s7ok4uw	1243	42	.	.	.
cord-001835-0s7ok4uw	1244	1	modules	module	NNS
cord-001835-0s7ok4uw	1244	2	.	.	.
cord-001835-0s7ok4uw	1245	1	Each	each	DT
cord-001835-0s7ok4uw	1245	2	CBR	CBR	NNP
cord-001835-0s7ok4uw	1245	3	comprises	comprise	VBZ
cord-001835-0s7ok4uw	1245	4	a	a	DT
cord-001835-0s7ok4uw	1245	5	b	b	NN
cord-001835-0s7ok4uw	1245	6	-	-	HYPH
cord-001835-0s7ok4uw	1245	7	hairpin	hairpin	NN
cord-001835-0s7ok4uw	1245	8	core	core	NN
cord-001835-0s7ok4uw	1245	9	followed	follow	VBN
cord-001835-0s7ok4uw	1245	10	by	by	IN
cord-001835-0s7ok4uw	1245	11	a	a	DT
cord-001835-0s7ok4uw	1245	12	short	short	JJ
cord-001835-0s7ok4uw	1245	13	linker	linker	NN
cord-001835-0s7ok4uw	1245	14	sequence	sequence	NN
cord-001835-0s7ok4uw	1245	15	.	.	.
cord-001835-0s7ok4uw	1246	1	Choline	choline	NN
cord-001835-0s7ok4uw	1246	2	molecules	molecule	NNS
cord-001835-0s7ok4uw	1246	3	are	be	VBP
cord-001835-0s7ok4uw	1246	4	bound	bind	VBN
cord-001835-0s7ok4uw	1246	5	between	between	IN
cord-001835-0s7ok4uw	1246	6	two	two	CD
cord-001835-0s7ok4uw	1246	7	consecutive	consecutive	JJ
cord-001835-0s7ok4uw	1246	8	repeats	repeat	NNS
cord-001835-0s7ok4uw	1246	9	through	through	IN
cord-001835-0s7ok4uw	1246	10	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	1246	11	and	and	CC
cord-001835-0s7ok4uw	1246	12	cation	cation	NN
cord-001835-0s7ok4uw	1246	13	-	-	HYPH
cord-001835-0s7ok4uw	1246	14	p	p	NN
cord-001835-0s7ok4uw	1246	15	interactions	interaction	NNS
cord-001835-0s7ok4uw	1246	16	with	with	IN
cord-001835-0s7ok4uw	1246	17	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	1246	18	side	side	NN
cord-001835-0s7ok4uw	1246	19	chains	chain	NNS
cord-001835-0s7ok4uw	1246	20	.	.	.
cord-001835-0s7ok4uw	1247	1	Apart	apart	RB
cord-001835-0s7ok4uw	1247	2	from	from	IN
cord-001835-0s7ok4uw	1247	3	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1247	4	biotechnological	biotechnological	JJ
cord-001835-0s7ok4uw	1247	5	applications	application	NNS
cord-001835-0s7ok4uw	1247	6	as	as	IN
cord-001835-0s7ok4uw	1247	7	an	an	DT
cord-001835-0s7ok4uw	1247	8	affinity	affinity	NN
cord-001835-0s7ok4uw	1247	9	tag	tag	NN
cord-001835-0s7ok4uw	1247	10	for	for	IN
cord-001835-0s7ok4uw	1247	11	protein	protein	NN
cord-001835-0s7ok4uw	1247	12	immobilization	immobilization	NN
cord-001835-0s7ok4uw	1247	13	and	and	CC
cord-001835-0s7ok4uw	1247	14	purification	purification	NN
cord-001835-0s7ok4uw	1247	15	,	,	,
cord-001835-0s7ok4uw	1247	16	CLytA	CLytA	NNP
cord-001835-0s7ok4uw	1247	17	is	be	VBZ
cord-001835-0s7ok4uw	1247	18	useful	useful	JJ
cord-001835-0s7ok4uw	1247	19	as	as	IN
cord-001835-0s7ok4uw	1247	20	a	a	DT
cord-001835-0s7ok4uw	1247	21	model	model	NN
cord-001835-0s7ok4uw	1247	22	for	for	IN
cord-001835-0s7ok4uw	1247	23	understanding	understand	VBG
cord-001835-0s7ok4uw	1247	24	the	the	DT
cord-001835-0s7ok4uw	1247	25	folding	folding	NN
cord-001835-0s7ok4uw	1247	26	and	and	CC
cord-001835-0s7ok4uw	1247	27	stability	stability	NN
cord-001835-0s7ok4uw	1247	28	of	of	IN
cord-001835-0s7ok4uw	1247	29	repeat	repeat	NN
cord-001835-0s7ok4uw	1247	30	proteins	protein	NNS
cord-001835-0s7ok4uw	1247	31	.	.	.
cord-001835-0s7ok4uw	1248	1	In	in	IN
cord-001835-0s7ok4uw	1248	2	this	this	DT
cord-001835-0s7ok4uw	1248	3	sense	sense	NN
cord-001835-0s7ok4uw	1248	4	,	,	,
cord-001835-0s7ok4uw	1248	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1248	6	proposed	propose	VBD
cord-001835-0s7ok4uw	1248	7	to	to	TO
cord-001835-0s7ok4uw	1248	8	get	get	VB
cord-001835-0s7ok4uw	1248	9	minimal	minimal	JJ
cord-001835-0s7ok4uw	1248	10	peptides	peptide	NNS
cord-001835-0s7ok4uw	1248	11	encompassing	encompass	VBG
cord-001835-0s7ok4uw	1248	12	the	the	DT
cord-001835-0s7ok4uw	1248	13	sequence	sequence	NN
cord-001835-0s7ok4uw	1248	14	of	of	IN
cord-001835-0s7ok4uw	1248	15	a	a	DT
cord-001835-0s7ok4uw	1248	16	single	single	JJ
cord-001835-0s7ok4uw	1248	17	CBR	cbr	NN
cord-001835-0s7ok4uw	1248	18	or	or	CC
cord-001835-0s7ok4uw	1248	19	even	even	RB
cord-001835-0s7ok4uw	1248	20	only	only	RB
cord-001835-0s7ok4uw	1248	21	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1248	22	b	b	NN
cord-001835-0s7ok4uw	1248	23	-	-	HYPH
cord-001835-0s7ok4uw	1248	24	hairpin	hairpin	NN
cord-001835-0s7ok4uw	1248	25	core	core	NN
cord-001835-0s7ok4uw	1248	26	able	able	JJ
cord-001835-0s7ok4uw	1248	27	to	to	TO
cord-001835-0s7ok4uw	1248	28	maintain	maintain	VB
cord-001835-0s7ok4uw	1248	29	the	the	DT
cord-001835-0s7ok4uw	1248	30	native	native	JJ
cord-001835-0s7ok4uw	1248	31	fold	fold	NN
cord-001835-0s7ok4uw	1248	32	and	and	CC
cord-001835-0s7ok4uw	1248	33	the	the	DT
cord-001835-0s7ok4uw	1248	34	ability	ability	NN
cord-001835-0s7ok4uw	1248	35	to	to	TO
cord-001835-0s7ok4uw	1248	36	bind	bind	VB
cord-001835-0s7ok4uw	1248	37	choline	choline	NN
cord-001835-0s7ok4uw	1248	38	.	.	.
cord-001835-0s7ok4uw	1249	1	To	to	IN
cord-001835-0s7ok4uw	1249	2	that	that	DT
cord-001835-0s7ok4uw	1249	3	end	end	NN
cord-001835-0s7ok4uw	1249	4	,	,	,
cord-001835-0s7ok4uw	1249	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1249	6	first	first	RB
cord-001835-0s7ok4uw	1249	7	proceeded	proceed	VBD
cord-001835-0s7ok4uw	1249	8	to	to	TO
cord-001835-0s7ok4uw	1249	9	analyze	analyze	VB
cord-001835-0s7ok4uw	1249	10	the	the	DT
cord-001835-0s7ok4uw	1249	11	peptide	peptide	NN
cord-001835-0s7ok4uw	1249	12	comprising	comprise	VBG
cord-001835-0s7ok4uw	1249	13	the	the	DT
cord-001835-0s7ok4uw	1249	14	third	third	JJ
cord-001835-0s7ok4uw	1249	15	b	b	NN
cord-001835-0s7ok4uw	1249	16	-	-	HYPH
cord-001835-0s7ok4uw	1249	17	hairpin	hairpin	NN
cord-001835-0s7ok4uw	1249	18	core	core	NN
cord-001835-0s7ok4uw	1249	19	,	,	,
cord-001835-0s7ok4uw	1249	20	denoted	denote	VBN
cord-001835-0s7ok4uw	1249	21	as	as	IN
cord-001835-0s7ok4uw	1249	22	CLyt3	CLyt3	NNP
cord-001835-0s7ok4uw	1249	23	.	.	.
cord-001835-0s7ok4uw	1250	1	Based	base	VBN
cord-001835-0s7ok4uw	1250	2	on	on	IN
cord-001835-0s7ok4uw	1250	3	CD	CD	NNP
cord-001835-0s7ok4uw	1250	4	and	and	CC
cord-001835-0s7ok4uw	1250	5	NMR	NMR	NNP
cord-001835-0s7ok4uw	1250	6	data	data	NN
cord-001835-0s7ok4uw	1250	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	1250	8	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	1250	9	that	that	IN
cord-001835-0s7ok4uw	1250	10	the	the	DT
cord-001835-0s7ok4uw	1250	11	peptide	peptide	NN
cord-001835-0s7ok4uw	1250	12	CLyt3	CLyt3	NNP
cord-001835-0s7ok4uw	1250	13	conserves	conserve	VBZ
cord-001835-0s7ok4uw	1250	14	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1250	15	native	native	JJ
cord-001835-0s7ok4uw	1250	16	bhairpin	bhairpin	JJ
cord-001835-0s7ok4uw	1250	17	structure	structure	NN
cord-001835-0s7ok4uw	1250	18	in	in	IN
cord-001835-0s7ok4uw	1250	19	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	1250	20	solution	solution	NN
cord-001835-0s7ok4uw	1250	21	,	,	,
cord-001835-0s7ok4uw	1250	22	but	but	CC
cord-001835-0s7ok4uw	1250	23	forms	form	VBZ
cord-001835-0s7ok4uw	1250	24	a	a	DT
cord-001835-0s7ok4uw	1250	25	stable	stable	JJ
cord-001835-0s7ok4uw	1250	26	,	,	,
cord-001835-0s7ok4uw	1250	27	amphipathic	amphipathic	NNP
cord-001835-0s7ok4uw	1250	28	a	a	DT
cord-001835-0s7ok4uw	1250	29	-	-	HYPH
cord-001835-0s7ok4uw	1250	30	helix	helix	NN
cord-001835-0s7ok4uw	1250	31	in	in	IN
cord-001835-0s7ok4uw	1250	32	detergent	detergent	NN
cord-001835-0s7ok4uw	1250	33	micelles	micelle	NNS
cord-001835-0s7ok4uw	1250	34	and	and	CC
cord-001835-0s7ok4uw	1250	35	as	as	RB
cord-001835-0s7ok4uw	1250	36	well	well	RB
cord-001835-0s7ok4uw	1250	37	as	as	IN
cord-001835-0s7ok4uw	1250	38	in	in	IN
cord-001835-0s7ok4uw	1250	39	small	small	JJ
cord-001835-0s7ok4uw	1250	40	lipid	lipid	NN
cord-001835-0s7ok4uw	1250	41	vesicles	vesicle	NNS
cord-001835-0s7ok4uw	1250	42	[	[	-LRB-
cord-001835-0s7ok4uw	1250	43	1	1	CD
cord-001835-0s7ok4uw	1250	44	]	]	-RRB-
cord-001835-0s7ok4uw	1250	45	.	.	.
cord-001835-0s7ok4uw	1251	1	Considering	consider	VBG
cord-001835-0s7ok4uw	1251	2	the	the	DT
cord-001835-0s7ok4uw	1251	3	great	great	JJ
cord-001835-0s7ok4uw	1251	4	differences	difference	NNS
cord-001835-0s7ok4uw	1251	5	in	in	IN
cord-001835-0s7ok4uw	1251	6	the	the	DT
cord-001835-0s7ok4uw	1251	7	distribution	distribution	NN
cord-001835-0s7ok4uw	1251	8	of	of	IN
cord-001835-0s7ok4uw	1251	9	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	1251	10	and	and	CC
cord-001835-0s7ok4uw	1251	11	polar	polar	JJ
cord-001835-0s7ok4uw	1251	12	side	side	NN
cord-001835-0s7ok4uw	1251	13	chains	chain	NNS
cord-001835-0s7ok4uw	1251	14	shown	show	VBN
cord-001835-0s7ok4uw	1251	15	by	by	IN
cord-001835-0s7ok4uw	1251	16	CLyt3	CLyt3	NNP
cord-001835-0s7ok4uw	1251	17	b	b	NN
cord-001835-0s7ok4uw	1251	18	-	-	HYPH
cord-001835-0s7ok4uw	1251	19	hairpin	hairpin	NN
cord-001835-0s7ok4uw	1251	20	and	and	CC
cord-001835-0s7ok4uw	1251	21	a	a	DT
cord-001835-0s7ok4uw	1251	22	-	-	HYPH
cord-001835-0s7ok4uw	1251	23	helix	helix	NN
cord-001835-0s7ok4uw	1251	24	,	,	,
cord-001835-0s7ok4uw	1251	25	we	-PRON-	PRP
cord-001835-0s7ok4uw	1251	26	propose	propose	VBP
cord-001835-0s7ok4uw	1251	27	that	that	IN
cord-001835-0s7ok4uw	1251	28	amphipathic	amphipathic	JJ
cord-001835-0s7ok4uw	1251	29	structures	structure	NNS
cord-001835-0s7ok4uw	1251	30	are	be	VBP
cord-001835-0s7ok4uw	1251	31	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	1251	32	in	in	IN
cord-001835-0s7ok4uw	1251	33	micelles	micelle	NNS
cord-001835-0s7ok4uw	1251	34	or	or	CC
cord-001835-0s7ok4uw	1251	35	lipid	lipid	NN
cord-001835-0s7ok4uw	1251	36	vesicles	vesicle	NNS
cord-001835-0s7ok4uw	1251	37	.	.	.
cord-001835-0s7ok4uw	1252	1	This	this	DT
cord-001835-0s7ok4uw	1252	2	"	"	``
cord-001835-0s7ok4uw	1252	3	dual	dual	JJ
cord-001835-0s7ok4uw	1252	4	"	"	''
cord-001835-0s7ok4uw	1252	5	behavior	behavior	NN
cord-001835-0s7ok4uw	1252	6	is	be	VBZ
cord-001835-0s7ok4uw	1252	7	the	the	DT
cord-001835-0s7ok4uw	1252	8	only	only	JJ
cord-001835-0s7ok4uw	1252	9	up	up	IN
cord-001835-0s7ok4uw	1252	10	-	-	HYPH
cord-001835-0s7ok4uw	1252	11	to	to	TO
cord-001835-0s7ok4uw	1252	12	-	-	HYPH
cord-001835-0s7ok4uw	1252	13	now	now	RB
cord-001835-0s7ok4uw	1252	14	reported	report	VBN
cord-001835-0s7ok4uw	1252	15	case	case	NN
cord-001835-0s7ok4uw	1252	16	of	of	IN
cord-001835-0s7ok4uw	1252	17	a	a	DT
cord-001835-0s7ok4uw	1252	18	micelle	micelle	NN
cord-001835-0s7ok4uw	1252	19	-	-	HYPH
cord-001835-0s7ok4uw	1252	20	induced	induce	VBN
cord-001835-0s7ok4uw	1252	21	conformational	conformational	JJ
cord-001835-0s7ok4uw	1252	22	transition	transition	NN
cord-001835-0s7ok4uw	1252	23	between	between	IN
cord-001835-0s7ok4uw	1252	24	two	two	CD
cord-001835-0s7ok4uw	1252	25	ordered	order	VBN
cord-001835-0s7ok4uw	1252	26	peptide	peptide	JJ
cord-001835-0s7ok4uw	1252	27	structures	structure	NNS
cord-001835-0s7ok4uw	1252	28	.	.	.
cord-001835-0s7ok4uw	1253	1	To	to	TO
cord-001835-0s7ok4uw	1253	2	check	check	VB
cord-001835-0s7ok4uw	1253	3	whether	whether	IN
cord-001835-0s7ok4uw	1253	4	other	other	JJ
cord-001835-0s7ok4uw	1253	5	CBR	CBR	NNP
cord-001835-0s7ok4uw	1253	6	repeats	repeat	VBZ
cord-001835-0s7ok4uw	1253	7	also	also	RB
cord-001835-0s7ok4uw	1253	8	undertake	undertake	VBP
cord-001835-0s7ok4uw	1253	9	b	b	NN
cord-001835-0s7ok4uw	1253	10	-	-	HYPH
cord-001835-0s7ok4uw	1253	11	hairpin	hairpin	NN
cord-001835-0s7ok4uw	1253	12	to	to	IN
cord-001835-0s7ok4uw	1253	13	a	a	DT
cord-001835-0s7ok4uw	1253	14	-	-	HYPH
cord-001835-0s7ok4uw	1253	15	helix	helix	NN
cord-001835-0s7ok4uw	1253	16	transition	transition	NN
cord-001835-0s7ok4uw	1253	17	in	in	IN
cord-001835-0s7ok4uw	1253	18	the	the	DT
cord-001835-0s7ok4uw	1253	19	presence	presence	NN
cord-001835-0s7ok4uw	1253	20	of	of	IN
cord-001835-0s7ok4uw	1253	21	micelles	micelle	NNS
cord-001835-0s7ok4uw	1253	22	,	,	,
cord-001835-0s7ok4uw	1253	23	so	so	IN
cord-001835-0s7ok4uw	1253	24	that	that	IN
cord-001835-0s7ok4uw	1253	25	it	-PRON-	PRP
cord-001835-0s7ok4uw	1253	26	represents	represent	VBZ
cord-001835-0s7ok4uw	1253	27	a	a	DT
cord-001835-0s7ok4uw	1253	28	general	general	JJ
cord-001835-0s7ok4uw	1253	29	tendency	tendency	NN
cord-001835-0s7ok4uw	1253	30	ascribed	ascribe	VBN
cord-001835-0s7ok4uw	1253	31	to	to	IN
cord-001835-0s7ok4uw	1253	32	all	all	DT
cord-001835-0s7ok4uw	1253	33	pneumococcal	pneumococcal	JJ
cord-001835-0s7ok4uw	1253	34	choline	choline	NN
cord-001835-0s7ok4uw	1253	35	-	-	HYPH
cord-001835-0s7ok4uw	1253	36	binding	bind	VBG
cord-001835-0s7ok4uw	1253	37	modules	module	NNS
cord-001835-0s7ok4uw	1253	38	,	,	,
cord-001835-0s7ok4uw	1253	39	we	-PRON-	PRP
cord-001835-0s7ok4uw	1253	40	will	will	MD
cord-001835-0s7ok4uw	1253	41	show	show	VB
cord-001835-0s7ok4uw	1253	42	new	new	JJ
cord-001835-0s7ok4uw	1253	43	experimental	experimental	JJ
cord-001835-0s7ok4uw	1253	44	evidences	evidence	NNS
cord-001835-0s7ok4uw	1253	45	based	base	VBN
cord-001835-0s7ok4uw	1253	46	on	on	IN
cord-001835-0s7ok4uw	1253	47	CD	CD	NNP
cord-001835-0s7ok4uw	1253	48	and	and	CC
cord-001835-0s7ok4uw	1253	49	NMR	NMR	NNP
cord-001835-0s7ok4uw	1253	50	structural	structural	JJ
cord-001835-0s7ok4uw	1253	51	studies	study	NNS
cord-001835-0s7ok4uw	1253	52	on	on	IN
cord-001835-0s7ok4uw	1253	53	peptides	peptide	NNS
cord-001835-0s7ok4uw	1253	54	derived	derive	VBN
cord-001835-0s7ok4uw	1253	55	from	from	IN
cord-001835-0s7ok4uw	1253	56	the	the	DT
cord-001835-0s7ok4uw	1253	57	bhairpin	bhairpin	NNP
cord-001835-0s7ok4uw	1253	58	cores	core	NNS
cord-001835-0s7ok4uw	1253	59	of	of	IN
cord-001835-0s7ok4uw	1253	60	other	other	JJ
cord-001835-0s7ok4uw	1253	61	CLytA	CLytA	NNP
cord-001835-0s7ok4uw	1253	62	repeats	repeat	NNS
cord-001835-0s7ok4uw	1253	63	,	,	,
cord-001835-0s7ok4uw	1253	64	as	as	RB
cord-001835-0s7ok4uw	1253	65	well	well	RB
cord-001835-0s7ok4uw	1253	66	as	as	IN
cord-001835-0s7ok4uw	1253	67	in	in	IN
cord-001835-0s7ok4uw	1253	68	modified	modify	VBN
cord-001835-0s7ok4uw	1253	69	CLyt3	CLyt3	NNP
cord-001835-0s7ok4uw	1253	70	peptides	peptide	NNS
cord-001835-0s7ok4uw	1253	71	.	.	.
cord-001835-0s7ok4uw	1254	1	Continuing	continue	VBG
cord-001835-0s7ok4uw	1254	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1254	3	studies	study	NNS
cord-001835-0s7ok4uw	1254	4	of	of	IN
cord-001835-0s7ok4uw	1254	5	the	the	DT
cord-001835-0s7ok4uw	1254	6	effect	effect	NN
cord-001835-0s7ok4uw	1254	7	of	of	IN
cord-001835-0s7ok4uw	1254	8	like	like	RB
cord-001835-0s7ok4uw	1254	9	-	-	HYPH
cord-001835-0s7ok4uw	1254	10	charged	charge	VBN
cord-001835-0s7ok4uw	1254	11	residues	residue	NNS
cord-001835-0s7ok4uw	1254	12	on	on	IN
cord-001835-0s7ok4uw	1254	13	protein	protein	NN
cord-001835-0s7ok4uw	1254	14	-	-	HYPH
cord-001835-0s7ok4uw	1254	15	folding	fold	VBG
cord-001835-0s7ok4uw	1254	16	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1254	17	,	,	,
cord-001835-0s7ok4uw	1254	18	in	in	IN
cord-001835-0s7ok4uw	1254	19	this	this	DT
cord-001835-0s7ok4uw	1254	20	work	work	NN
cord-001835-0s7ok4uw	1254	21	,	,	,
cord-001835-0s7ok4uw	1254	22	we	-PRON-	PRP
cord-001835-0s7ok4uw	1254	23	investigated	investigate	VBD
cord-001835-0s7ok4uw	1254	24	,	,	,
cord-001835-0s7ok4uw	1254	25	by	by	IN
cord-001835-0s7ok4uw	1254	26	means	mean	NNS
cord-001835-0s7ok4uw	1254	27	of	of	IN
cord-001835-0s7ok4uw	1254	28	NMR	NMR	NNP
cord-001835-0s7ok4uw	1254	29	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1254	30	and	and	CC
cord-001835-0s7ok4uw	1254	31	molecular	molecular	JJ
cord-001835-0s7ok4uw	1254	32	-	-	HYPH
cord-001835-0s7ok4uw	1254	33	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1254	34	simulations	simulation	NNS
cord-001835-0s7ok4uw	1254	35	,	,	,
cord-001835-0s7ok4uw	1254	36	two	two	CD
cord-001835-0s7ok4uw	1254	37	short	short	JJ
cord-001835-0s7ok4uw	1254	38	fragments	fragment	NNS
cord-001835-0s7ok4uw	1254	39	of	of	IN
cord-001835-0s7ok4uw	1254	40	the	the	DT
cord-001835-0s7ok4uw	1254	41	human	human	JJ
cord-001835-0s7ok4uw	1254	42	Pin1	Pin1	NNP
cord-001835-0s7ok4uw	1254	43	WW	WW	NNP
cord-001835-0s7ok4uw	1254	44	domain	domain	NN
cord-001835-0s7ok4uw	1254	45	[	[	-LRB-
cord-001835-0s7ok4uw	1254	46	hPin1(14	hpin1(14	CD
cord-001835-0s7ok4uw	1254	47	-	-	HYPH
cord-001835-0s7ok4uw	1254	48	24	24	CD
cord-001835-0s7ok4uw	1254	49	)	)	-RRB-
cord-001835-0s7ok4uw	1254	50	;	;	:
cord-001835-0s7ok4uw	1254	51	hPin1(15	hpin1(15	ADD
cord-001835-0s7ok4uw	1254	52	-	-	HYPH
cord-001835-0s7ok4uw	1254	53	23	23	CD
cord-001835-0s7ok4uw	1254	54	)	)	-RRB-
cord-001835-0s7ok4uw	1254	55	]	]	-RRB-
cord-001835-0s7ok4uw	1254	56	and	and	CC
cord-001835-0s7ok4uw	1254	57	one	one	CD
cord-001835-0s7ok4uw	1254	58	single	single	JJ
cord-001835-0s7ok4uw	1254	59	point	point	NN
cord-001835-0s7ok4uw	1254	60	mutation	mutation	NN
cord-001835-0s7ok4uw	1254	61	system	system	NN
cord-001835-0s7ok4uw	1254	62	derived	derive	VBN
cord-001835-0s7ok4uw	1254	63	from	from	IN
cord-001835-0s7ok4uw	1254	64	hPin1(14	hpin1(14	CD
cord-001835-0s7ok4uw	1254	65	-	-	HYPH
cord-001835-0s7ok4uw	1254	66	24	24	CD
cord-001835-0s7ok4uw	1254	67	)	)	-RRB-
cord-001835-0s7ok4uw	1254	68	in	in	IN
cord-001835-0s7ok4uw	1254	69	which	which	WDT
cord-001835-0s7ok4uw	1254	70	the	the	DT
cord-001835-0s7ok4uw	1254	71	original	original	JJ
cord-001835-0s7ok4uw	1254	72	charged	charge	VBN
cord-001835-0s7ok4uw	1254	73	residues	residue	NNS
cord-001835-0s7ok4uw	1254	74	were	be	VBD
cord-001835-0s7ok4uw	1254	75	replaced	replace	VBN
cord-001835-0s7ok4uw	1254	76	with	with	IN
cord-001835-0s7ok4uw	1254	77	non	non	JJ
cord-001835-0s7ok4uw	1254	78	-	-	JJ
cord-001835-0s7ok4uw	1254	79	polar	polar	JJ
cord-001835-0s7ok4uw	1254	80	alanine	alanine	NN
cord-001835-0s7ok4uw	1254	81	residues	residue	NNS
cord-001835-0s7ok4uw	1254	82	.	.	.
cord-001835-0s7ok4uw	1255	1	Results	result	NNS
cord-001835-0s7ok4uw	1255	2	,	,	,
cord-001835-0s7ok4uw	1255	3	for	for	IN
cord-001835-0s7ok4uw	1255	4	both	both	DT
cord-001835-0s7ok4uw	1255	5	original	original	JJ
cord-001835-0s7ok4uw	1255	6	peptide	peptide	NN
cord-001835-0s7ok4uw	1255	7	fragments	fragment	NNS
cord-001835-0s7ok4uw	1255	8	of	of	IN
cord-001835-0s7ok4uw	1255	9	hPin1	hPin1	NNP
cord-001835-0s7ok4uw	1255	10	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	1255	11	the	the	DT
cord-001835-0s7ok4uw	1255	12	presence	presence	NN
cord-001835-0s7ok4uw	1255	13	of	of	IN
cord-001835-0s7ok4uw	1255	14	ensembles	ensemble	NNS
cord-001835-0s7ok4uw	1255	15	of	of	IN
cord-001835-0s7ok4uw	1255	16	structures	structure	NNS
cord-001835-0s7ok4uw	1255	17	with	with	IN
cord-001835-0s7ok4uw	1255	18	a	a	DT
cord-001835-0s7ok4uw	1255	19	tendency	tendency	NN
cord-001835-0s7ok4uw	1255	20	to	to	TO
cord-001835-0s7ok4uw	1255	21	form	form	VB
cord-001835-0s7ok4uw	1255	22	a	a	DT
cord-001835-0s7ok4uw	1255	23	b	b	NN
cord-001835-0s7ok4uw	1255	24	-	-	HYPH
cord-001835-0s7ok4uw	1255	25	chain	chain	NN
cord-001835-0s7ok4uw	1255	26	reversal	reversal	NN
cord-001835-0s7ok4uw	1255	27	.	.	.
cord-001835-0s7ok4uw	1256	1	Understanding	understand	VBG
cord-001835-0s7ok4uw	1256	2	the	the	DT
cord-001835-0s7ok4uw	1256	3	biology	biology	NN
cord-001835-0s7ok4uw	1256	4	of	of	IN
cord-001835-0s7ok4uw	1256	5	Huntington	Huntington	NNP
cord-001835-0s7ok4uw	1256	6	's	's	POS
cord-001835-0s7ok4uw	1256	7	disease	disease	NN
cord-001835-0s7ok4uw	1256	8	via	via	IN
cord-001835-0s7ok4uw	1256	9	the	the	DT
cord-001835-0s7ok4uw	1256	10	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	1256	11	huntingtin	huntingtin	NNPS
cord-001835-0s7ok4uw	1256	12	monomer	monomer	NN
cord-001835-0s7ok4uw	1256	13	Huntington	Huntington	NNP
cord-001835-0s7ok4uw	1256	14	's	's	POS
cord-001835-0s7ok4uw	1256	15	disease	disease	NN
cord-001835-0s7ok4uw	1256	16	(	(	-LRB-
cord-001835-0s7ok4uw	1256	17	HD	HD	NNP
cord-001835-0s7ok4uw	1256	18	)	)	-RRB-
cord-001835-0s7ok4uw	1256	19	is	be	VBZ
cord-001835-0s7ok4uw	1256	20	caused	cause	VBN
cord-001835-0s7ok4uw	1256	21	by	by	IN
cord-001835-0s7ok4uw	1256	22	an	an	DT
cord-001835-0s7ok4uw	1256	23	abnormal	abnormal	JJ
cord-001835-0s7ok4uw	1256	24	extension	extension	NN
cord-001835-0s7ok4uw	1256	25	of	of	IN
cord-001835-0s7ok4uw	1256	26	the	the	DT
cord-001835-0s7ok4uw	1256	27	polyglutamine	polyglutamine	NN
cord-001835-0s7ok4uw	1256	28	(	(	-LRB-
cord-001835-0s7ok4uw	1256	29	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	1256	30	)	)	-RRB-
cord-001835-0s7ok4uw	1256	31	region	region	NN
cord-001835-0s7ok4uw	1256	32	within	within	IN
cord-001835-0s7ok4uw	1256	33	exon	exon	NN
cord-001835-0s7ok4uw	1256	34	1	1	CD
cord-001835-0s7ok4uw	1256	35	of	of	IN
cord-001835-0s7ok4uw	1256	36	the	the	DT
cord-001835-0s7ok4uw	1256	37	protein	protein	NN
cord-001835-0s7ok4uw	1256	38	huntingtin	huntingtin	NNS
cord-001835-0s7ok4uw	1256	39	from	from	IN
cord-001835-0s7ok4uw	1256	40	typically	typically	RB
cord-001835-0s7ok4uw	1256	41	25	25	CD
cord-001835-0s7ok4uw	1256	42	glutamines	glutamine	NNS
cord-001835-0s7ok4uw	1256	43	to	to	IN
cord-001835-0s7ok4uw	1256	44	over	over	IN
cord-001835-0s7ok4uw	1256	45	36	36	CD
cord-001835-0s7ok4uw	1256	46	.	.	.
cord-001835-0s7ok4uw	1257	1	Disease	Disease	NNP
cord-001835-0s7ok4uw	1257	2	onset	onset	NN
cord-001835-0s7ok4uw	1257	3	correlates	correlate	VBZ
cord-001835-0s7ok4uw	1257	4	with	with	IN
cord-001835-0s7ok4uw	1257	5	the	the	DT
cord-001835-0s7ok4uw	1257	6	huntingtin	huntingtin	NNS
cord-001835-0s7ok4uw	1257	7	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	1257	8	and	and	CC
cord-001835-0s7ok4uw	1257	9	causing	cause	VBG
cord-001835-0s7ok4uw	1257	10	the	the	DT
cord-001835-0s7ok4uw	1257	11	formation	formation	NN
cord-001835-0s7ok4uw	1257	12	of	of	IN
cord-001835-0s7ok4uw	1257	13	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	1257	14	,	,	,
cord-001835-0s7ok4uw	1257	15	however	however	RB
cord-001835-0s7ok4uw	1257	16	recent	recent	JJ
cord-001835-0s7ok4uw	1257	17	studies	study	NNS
cord-001835-0s7ok4uw	1257	18	have	have	VBP
cord-001835-0s7ok4uw	1257	19	postulated	postulate	VBN
cord-001835-0s7ok4uw	1257	20	that	that	IN
cord-001835-0s7ok4uw	1257	21	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	1257	22	huntingtin	huntingtin	NNS
cord-001835-0s7ok4uw	1257	23	monomer	monomer	NN
cord-001835-0s7ok4uw	1257	24	may	may	MD
cord-001835-0s7ok4uw	1257	25	form	form	VB
cord-001835-0s7ok4uw	1257	26	compact	compact	JJ
cord-001835-0s7ok4uw	1257	27	structures	structure	NNS
cord-001835-0s7ok4uw	1257	28	that	that	WDT
cord-001835-0s7ok4uw	1257	29	are	be	VBP
cord-001835-0s7ok4uw	1257	30	responsible	responsible	JJ
cord-001835-0s7ok4uw	1257	31	for	for	IN
cord-001835-0s7ok4uw	1257	32	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	1257	33	toxicity	toxicity	NN
cord-001835-0s7ok4uw	1257	34	in	in	IN
cord-001835-0s7ok4uw	1257	35	HD	hd	NN
cord-001835-0s7ok4uw	1257	36	.	.	.
cord-001835-0s7ok4uw	1258	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1258	2	sought	seek	VBD
cord-001835-0s7ok4uw	1258	3	to	to	TO
cord-001835-0s7ok4uw	1258	4	examine	examine	VB
cord-001835-0s7ok4uw	1258	5	the	the	DT
cord-001835-0s7ok4uw	1258	6	conformation	conformation	NN
cord-001835-0s7ok4uw	1258	7	of	of	IN
cord-001835-0s7ok4uw	1258	8	huntingtin	huntingtin	NNS
cord-001835-0s7ok4uw	1258	9	monomers	monomer	NNS
cord-001835-0s7ok4uw	1258	10	,	,	,
cord-001835-0s7ok4uw	1258	11	how	how	WRB
cord-001835-0s7ok4uw	1258	12	polyQ	polyq	JJ
cord-001835-0s7ok4uw	1258	13	sequence	sequence	NN
cord-001835-0s7ok4uw	1258	14	length	length	NN
cord-001835-0s7ok4uw	1258	15	affects	affect	VBZ
cord-001835-0s7ok4uw	1258	16	monomer	monomer	NN
cord-001835-0s7ok4uw	1258	17	structure	structure	NN
cord-001835-0s7ok4uw	1258	18	and	and	CC
cord-001835-0s7ok4uw	1258	19	which	which	WDT
cord-001835-0s7ok4uw	1258	20	protein	protein	NN
cord-001835-0s7ok4uw	1258	21	-	-	HYPH
cord-001835-0s7ok4uw	1258	22	binding	bind	VBG
cord-001835-0s7ok4uw	1258	23	partners	partner	NNS
cord-001835-0s7ok4uw	1258	24	in	in	IN
cord-001835-0s7ok4uw	1258	25	the	the	DT
cord-001835-0s7ok4uw	1258	26	cell	cell	NN
cord-001835-0s7ok4uw	1258	27	may	may	MD
cord-001835-0s7ok4uw	1258	28	exert	exert	VB
cord-001835-0s7ok4uw	1258	29	a	a	DT
cord-001835-0s7ok4uw	1258	30	gain	gain	NN
cord-001835-0s7ok4uw	1258	31	-	-	HYPH
cord-001835-0s7ok4uw	1258	32	of	of	IN
cord-001835-0s7ok4uw	1258	33	-	-	HYPH
cord-001835-0s7ok4uw	1258	34	toxic	toxic	JJ
cord-001835-0s7ok4uw	1258	35	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1258	36	in	in	IN
cord-001835-0s7ok4uw	1258	37	pathology	pathology	NN
cord-001835-0s7ok4uw	1258	38	.	.	.
cord-001835-0s7ok4uw	1259	1	Hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	1259	2	-	-	HYPH
cord-001835-0s7ok4uw	1259	3	deuterium	deuterium	NN
cord-001835-0s7ok4uw	1259	4	exchange	exchange	NN
cord-001835-0s7ok4uw	1259	5	mass	mass	NN
cord-001835-0s7ok4uw	1259	6	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	1259	7	was	be	VBD
cord-001835-0s7ok4uw	1259	8	used	use	VBN
cord-001835-0s7ok4uw	1259	9	to	to	TO
cord-001835-0s7ok4uw	1259	10	measure	measure	VB
cord-001835-0s7ok4uw	1259	11	the	the	DT
cord-001835-0s7ok4uw	1259	12	degree	degree	NN
cord-001835-0s7ok4uw	1259	13	of	of	IN
cord-001835-0s7ok4uw	1259	14	structure	structure	NN
cord-001835-0s7ok4uw	1259	15	in	in	IN
cord-001835-0s7ok4uw	1259	16	both	both	CC
cord-001835-0s7ok4uw	1259	17	non	non	JJ
cord-001835-0s7ok4uw	1259	18	-	-	JJ
cord-001835-0s7ok4uw	1259	19	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	1259	20	(	(	-LRB-
cord-001835-0s7ok4uw	1259	21	25Q	25Q	NNP
cord-001835-0s7ok4uw	1259	22	)	)	-RRB-
cord-001835-0s7ok4uw	1259	23	and	and	CC
cord-001835-0s7ok4uw	1259	24	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	1259	25	(	(	-LRB-
cord-001835-0s7ok4uw	1259	26	46Q	46q	LS
cord-001835-0s7ok4uw	1259	27	)	)	-RRB-
cord-001835-0s7ok4uw	1259	28	huntingtin	huntingtin	NNPS
cord-001835-0s7ok4uw	1259	29	,	,	,
cord-001835-0s7ok4uw	1259	30	with	with	IN
cord-001835-0s7ok4uw	1259	31	results	result	NNS
cord-001835-0s7ok4uw	1259	32	showing	show	VBG
cord-001835-0s7ok4uw	1259	33	that	that	IN
cord-001835-0s7ok4uw	1259	34	both	both	DT
cord-001835-0s7ok4uw	1259	35	forms	form	NNS
cord-001835-0s7ok4uw	1259	36	exchanged	exchange	VBD
cord-001835-0s7ok4uw	1259	37	79	79	CD
cord-001835-0s7ok4uw	1259	38	%	%	NN
cord-001835-0s7ok4uw	1259	39	of	of	IN
cord-001835-0s7ok4uw	1259	40	potential	potential	JJ
cord-001835-0s7ok4uw	1259	41	NH	NH	NNP
cord-001835-0s7ok4uw	1259	42	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	1259	43	bond	bond	NN
cord-001835-0s7ok4uw	1259	44	donors	donor	NNS
cord-001835-0s7ok4uw	1259	45	within	within	IN
cord-001835-0s7ok4uw	1259	46	30	30	CD
cord-001835-0s7ok4uw	1259	47	seconds	second	NNS
cord-001835-0s7ok4uw	1259	48	(	(	-LRB-
cord-001835-0s7ok4uw	1259	49	n53	n53	NN
cord-001835-0s7ok4uw	1259	50	)	)	-RRB-
cord-001835-0s7ok4uw	1259	51	,	,	,
cord-001835-0s7ok4uw	1259	52	with	with	IN
cord-001835-0s7ok4uw	1259	53	little	little	JJ
cord-001835-0s7ok4uw	1259	54	to	to	TO
cord-001835-0s7ok4uw	1259	55	no	no	DT
cord-001835-0s7ok4uw	1259	56	further	further	JJ
cord-001835-0s7ok4uw	1259	57	exchange	exchange	NN
cord-001835-0s7ok4uw	1259	58	over	over	IN
cord-001835-0s7ok4uw	1259	59	the	the	DT
cord-001835-0s7ok4uw	1259	60	following	following	JJ
cord-001835-0s7ok4uw	1259	61	ten	ten	CD
cord-001835-0s7ok4uw	1259	62	minutes	minute	NNS
cord-001835-0s7ok4uw	1259	63	.	.	.
cord-001835-0s7ok4uw	1260	1	This	this	DT
cord-001835-0s7ok4uw	1260	2	result	result	NN
cord-001835-0s7ok4uw	1260	3	suggested	suggest	VBD
cord-001835-0s7ok4uw	1260	4	that	that	IN
cord-001835-0s7ok4uw	1260	5	the	the	DT
cord-001835-0s7ok4uw	1260	6	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	1260	7	conformations	conformation	NNS
cord-001835-0s7ok4uw	1260	8	are	be	VBP
cord-001835-0s7ok4uw	1260	9	not	not	RB
cord-001835-0s7ok4uw	1260	10	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	1260	11	by	by	IN
cord-001835-0s7ok4uw	1260	12	slow	slow	JJ
cord-001835-0s7ok4uw	1260	13	exchanging	exchange	VBG
cord-001835-0s7ok4uw	1260	14	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	1260	15	bonds	bond	NNS
cord-001835-0s7ok4uw	1260	16	.	.	.
cord-001835-0s7ok4uw	1261	1	Binding	bind	VBG
cord-001835-0s7ok4uw	1261	2	partners	partner	NNS
cord-001835-0s7ok4uw	1261	3	to	to	IN
cord-001835-0s7ok4uw	1261	4	the	the	DT
cord-001835-0s7ok4uw	1261	5	monomer	monomer	NN
cord-001835-0s7ok4uw	1261	6	were	be	VBD
cord-001835-0s7ok4uw	1261	7	assessed	assess	VBN
cord-001835-0s7ok4uw	1261	8	in	in	IN
cord-001835-0s7ok4uw	1261	9	Neuro2a	Neuro2a	NNP
cord-001835-0s7ok4uw	1261	10	cell	cell	NN
cord-001835-0s7ok4uw	1261	11	culture	culture	NN
cord-001835-0s7ok4uw	1261	12	by	by	IN
cord-001835-0s7ok4uw	1261	13	immunoprecipitation	immunoprecipitation	NN
cord-001835-0s7ok4uw	1261	14	and	and	CC
cord-001835-0s7ok4uw	1261	15	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	1261	16	MS/	MS/	NNP
cord-001835-0s7ok4uw	1261	17	MS	MS	NNP
cord-001835-0s7ok4uw	1261	18	proteomics	proteomic	NNS
cord-001835-0s7ok4uw	1261	19	approaches	approach	NNS
cord-001835-0s7ok4uw	1261	20	after	after	IN
cord-001835-0s7ok4uw	1261	21	depletion	depletion	NN
cord-001835-0s7ok4uw	1261	22	of	of	IN
cord-001835-0s7ok4uw	1261	23	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	1261	24	by	by	IN
cord-001835-0s7ok4uw	1261	25	pelleting	pellete	VBG
cord-001835-0s7ok4uw	1261	26	.	.	.
cord-001835-0s7ok4uw	1262	1	Proteins	protein	NNS
cord-001835-0s7ok4uw	1262	2	that	that	WDT
cord-001835-0s7ok4uw	1262	3	more	more	RBR
cord-001835-0s7ok4uw	1262	4	prevalently	prevalently	RB
cord-001835-0s7ok4uw	1262	5	co	co	JJ
cord-001835-0s7ok4uw	1262	6	-	-	VBN
cord-001835-0s7ok4uw	1262	7	precipitated	precipitate	VBN
cord-001835-0s7ok4uw	1262	8	with	with	IN
cord-001835-0s7ok4uw	1262	9	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	1262	10	huntingtin	huntingtin	NNS
cord-001835-0s7ok4uw	1262	11	included	include	VBD
cord-001835-0s7ok4uw	1262	12	Fused	fuse	VBN
cord-001835-0s7ok4uw	1262	13	in	in	IN
cord-001835-0s7ok4uw	1262	14	sarcoma	sarcoma	NN
cord-001835-0s7ok4uw	1262	15	(	(	-LRB-
cord-001835-0s7ok4uw	1262	16	Fus	Fus	NNP
cord-001835-0s7ok4uw	1262	17	)	)	-RRB-
cord-001835-0s7ok4uw	1262	18	,	,	,
cord-001835-0s7ok4uw	1262	19	glycine	glycine	NN
cord-001835-0s7ok4uw	1262	20	-	-	HYPH
cord-001835-0s7ok4uw	1262	21	tRNA	trna	NN
cord-001835-0s7ok4uw	1262	22	ligase	ligase	NN
cord-001835-0s7ok4uw	1262	23	(	(	-LRB-
cord-001835-0s7ok4uw	1262	24	Gars	Gars	NNP
cord-001835-0s7ok4uw	1262	25	)	)	-RRB-
cord-001835-0s7ok4uw	1262	26	,	,	,
cord-001835-0s7ok4uw	1262	27	peroxiredoxin	peroxiredoxin	NNP
cord-001835-0s7ok4uw	1262	28	6	6	CD
cord-001835-0s7ok4uw	1262	29	(	(	-LRB-
cord-001835-0s7ok4uw	1262	30	Prdx6	Prdx6	NNP
cord-001835-0s7ok4uw	1262	31	)	)	-RRB-
cord-001835-0s7ok4uw	1262	32	,	,	,
cord-001835-0s7ok4uw	1262	33	phosphatidylethanolamine	phosphatidylethanolamine	NN
cord-001835-0s7ok4uw	1262	34	-	-	HYPH
cord-001835-0s7ok4uw	1262	35	binding	bind	VBG
cord-001835-0s7ok4uw	1262	36	protein	protein	NN
cord-001835-0s7ok4uw	1262	37	1	1	CD
cord-001835-0s7ok4uw	1262	38	(	(	-LRB-
cord-001835-0s7ok4uw	1262	39	Pebp1	pebp1	JJ
cord-001835-0s7ok4uw	1262	40	/	/	SYM
cord-001835-0s7ok4uw	1262	41	Rkip	Rkip	NNP
cord-001835-0s7ok4uw	1262	42	)	)	-RRB-
cord-001835-0s7ok4uw	1262	43	,	,	,
cord-001835-0s7ok4uw	1262	44	and	and	CC
cord-001835-0s7ok4uw	1262	45	histone	histone	NN
cord-001835-0s7ok4uw	1262	46	subunit	subunit	NN
cord-001835-0s7ok4uw	1262	47	Hist1H4a	Hist1H4a	NNP
cord-001835-0s7ok4uw	1262	48	,	,	,
cord-001835-0s7ok4uw	1262	49	all	all	DT
cord-001835-0s7ok4uw	1262	50	of	of	IN
cord-001835-0s7ok4uw	1262	51	which	which	WDT
cord-001835-0s7ok4uw	1262	52	were	be	VBD
cord-001835-0s7ok4uw	1262	53	significantly	significantly	RB
cord-001835-0s7ok4uw	1262	54	enriched	enrich	VBN
cord-001835-0s7ok4uw	1262	55	by	by	IN
cord-001835-0s7ok4uw	1262	56	two	two	CD
cord-001835-0s7ok4uw	1262	57	-	-	RB
cord-001835-0s7ok4uw	1262	58	fold	fold	NN
cord-001835-0s7ok4uw	1262	59	or	or	CC
cord-001835-0s7ok4uw	1262	60	greater	great	JJR
cord-001835-0s7ok4uw	1262	61	.	.	.
cord-001835-0s7ok4uw	1263	1	RNA	RNA	NNP
cord-001835-0s7ok4uw	1263	2	-	-	HYPH
cord-001835-0s7ok4uw	1263	3	seq	seq	NN
cord-001835-0s7ok4uw	1263	4	analysis	analysis	NN
cord-001835-0s7ok4uw	1263	5	indicated	indicate	VBD
cord-001835-0s7ok4uw	1263	6	that	that	IN
cord-001835-0s7ok4uw	1263	7	none	none	NN
cord-001835-0s7ok4uw	1263	8	of	of	IN
cord-001835-0s7ok4uw	1263	9	these	these	DT
cord-001835-0s7ok4uw	1263	10	proteins	protein	NNS
cord-001835-0s7ok4uw	1263	11	had	have	VBD
cord-001835-0s7ok4uw	1263	12	altered	alter	VBN
cord-001835-0s7ok4uw	1263	13	expression	expression	NN
cord-001835-0s7ok4uw	1263	14	levels	level	NNS
cord-001835-0s7ok4uw	1263	15	,	,	,
cord-001835-0s7ok4uw	1263	16	suggesting	suggest	VBG
cord-001835-0s7ok4uw	1263	17	that	that	IN
cord-001835-0s7ok4uw	1263	18	the	the	DT
cord-001835-0s7ok4uw	1263	19	binding	bind	VBG
cord-001835-0s7ok4uw	1263	20	interactions	interaction	NNS
cord-001835-0s7ok4uw	1263	21	are	be	VBP
cord-001835-0s7ok4uw	1263	22	not	not	RB
cord-001835-0s7ok4uw	1263	23	due	due	JJ
cord-001835-0s7ok4uw	1263	24	to	to	IN
cord-001835-0s7ok4uw	1263	25	changes	change	NNS
cord-001835-0s7ok4uw	1263	26	in	in	IN
cord-001835-0s7ok4uw	1263	27	background	background	NN
cord-001835-0s7ok4uw	1263	28	abundance	abundance	NN
cord-001835-0s7ok4uw	1263	29	.	.	.
cord-001835-0s7ok4uw	1264	1	Overall	overall	RB
cord-001835-0s7ok4uw	1264	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	1264	3	found	find	VBD
cord-001835-0s7ok4uw	1264	4	that	that	IN
cord-001835-0s7ok4uw	1264	5	the	the	DT
cord-001835-0s7ok4uw	1264	6	conformational	conformational	JJ
cord-001835-0s7ok4uw	1264	7	differences	difference	NNS
cord-001835-0s7ok4uw	1264	8	are	be	VBP
cord-001835-0s7ok4uw	1264	9	subtle	subtle	JJ
cord-001835-0s7ok4uw	1264	10	,	,	,
cord-001835-0s7ok4uw	1264	11	yet	yet	CC
cord-001835-0s7ok4uw	1264	12	are	be	VBP
cord-001835-0s7ok4uw	1264	13	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	1264	14	to	to	TO
cord-001835-0s7ok4uw	1264	15	generate	generate	VB
cord-001835-0s7ok4uw	1264	16	several	several	JJ
cord-001835-0s7ok4uw	1264	17	specific	specific	JJ
cord-001835-0s7ok4uw	1264	18	proteome	proteome	NN
cord-001835-0s7ok4uw	1264	19	interactions	interaction	NNS
cord-001835-0s7ok4uw	1264	20	that	that	WDT
cord-001835-0s7ok4uw	1264	21	offer	offer	VBP
cord-001835-0s7ok4uw	1264	22	clues	clue	NNS
cord-001835-0s7ok4uw	1264	23	to	to	IN
cord-001835-0s7ok4uw	1264	24	a	a	DT
cord-001835-0s7ok4uw	1264	25	toxic	toxic	JJ
cord-001835-0s7ok4uw	1264	26	gain	gain	NN
cord-001835-0s7ok4uw	1264	27	-	-	HYPH
cord-001835-0s7ok4uw	1264	28	of	of	IN
cord-001835-0s7ok4uw	1264	29	-	-	HYPH
cord-001835-0s7ok4uw	1264	30	function	function	NN
cord-001835-0s7ok4uw	1264	31	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1264	32	in	in	IN
cord-001835-0s7ok4uw	1264	33	pathology	pathology	NN
cord-001835-0s7ok4uw	1264	34	.	.	.
cord-001835-0s7ok4uw	1265	1	Work	work	NN
cord-001835-0s7ok4uw	1265	2	is	be	VBZ
cord-001835-0s7ok4uw	1265	3	ongoing	ongoing	JJ
cord-001835-0s7ok4uw	1265	4	to	to	TO
cord-001835-0s7ok4uw	1265	5	probe	probe	VB
cord-001835-0s7ok4uw	1265	6	the	the	DT
cord-001835-0s7ok4uw	1265	7	more	more	RBR
cord-001835-0s7ok4uw	1265	8	subtle	subtle	JJ
cord-001835-0s7ok4uw	1265	9	changes	change	NNS
cord-001835-0s7ok4uw	1265	10	in	in	IN
cord-001835-0s7ok4uw	1265	11	conformation	conformation	NN
cord-001835-0s7ok4uw	1265	12	and	and	CC
cord-001835-0s7ok4uw	1265	13	the	the	DT
cord-001835-0s7ok4uw	1265	14	importance	importance	NN
cord-001835-0s7ok4uw	1265	15	of	of	IN
cord-001835-0s7ok4uw	1265	16	these	these	DT
cord-001835-0s7ok4uw	1265	17	interactors	interactor	NNS
cord-001835-0s7ok4uw	1265	18	to	to	IN
cord-001835-0s7ok4uw	1265	19	mediating	mediate	VBG
cord-001835-0s7ok4uw	1265	20	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1265	21	of	of	IN
cord-001835-0s7ok4uw	1265	22	dysfunction	dysfunction	NN
cord-001835-0s7ok4uw	1265	23	.	.	.
cord-001835-0s7ok4uw	1265	24	 	 	_SP
cord-001835-0s7ok4uw	1266	1	Hereditary	hereditary	JJ
cord-001835-0s7ok4uw	1266	2	tyrosinemia	tyrosinemia	NN
cord-001835-0s7ok4uw	1266	3	type	type	NN
cord-001835-0s7ok4uw	1267	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	1267	2	is	be	VBZ
cord-001835-0s7ok4uw	1267	3	an	an	DT
cord-001835-0s7ok4uw	1267	4	autosomal	autosomal	JJ
cord-001835-0s7ok4uw	1267	5	recesive	recesive	NN
cord-001835-0s7ok4uw	1267	6	disorder	disorder	NN
cord-001835-0s7ok4uw	1267	7	caused	cause	VBN
cord-001835-0s7ok4uw	1267	8	by	by	IN
cord-001835-0s7ok4uw	1267	9	deficiency	deficiency	NN
cord-001835-0s7ok4uw	1267	10	of	of	IN
cord-001835-0s7ok4uw	1267	11	fumarylacetoacetate	fumarylacetoacetate	NNP
cord-001835-0s7ok4uw	1267	12	hydrolase	hydrolase	NN
cord-001835-0s7ok4uw	1267	13	(	(	-LRB-
cord-001835-0s7ok4uw	1267	14	FAH	FAH	NNP
cord-001835-0s7ok4uw	1267	15	)	)	-RRB-
cord-001835-0s7ok4uw	1267	16	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1267	17	.	.	.
cord-001835-0s7ok4uw	1268	1	Deficiency	deficiency	NN
cord-001835-0s7ok4uw	1268	2	of	of	IN
cord-001835-0s7ok4uw	1268	3	FAH	FAH	NNP
cord-001835-0s7ok4uw	1268	4	leads	lead	VBZ
cord-001835-0s7ok4uw	1268	5	to	to	IN
cord-001835-0s7ok4uw	1268	6	cellular	cellular	JJ
cord-001835-0s7ok4uw	1268	7	accumulation	accumulation	NN
cord-001835-0s7ok4uw	1268	8	of	of	IN
cord-001835-0s7ok4uw	1268	9	toxic	toxic	JJ
cord-001835-0s7ok4uw	1268	10	metabolites	metabolite	NNS
cord-001835-0s7ok4uw	1268	11	which	which	WDT
cord-001835-0s7ok4uw	1268	12	include	include	VBP
cord-001835-0s7ok4uw	1268	13	mainly	mainly	RB
cord-001835-0s7ok4uw	1268	14	,	,	,
cord-001835-0s7ok4uw	1268	15	succinylacetone	succinylacetone	NNP
cord-001835-0s7ok4uw	1268	16	(	(	-LRB-
cord-001835-0s7ok4uw	1268	17	SA	SA	NNP
cord-001835-0s7ok4uw	1268	18	)	)	-RRB-
cord-001835-0s7ok4uw	1268	19	,	,	,
cord-001835-0s7ok4uw	1268	20	maleylacetoacetate	maleylacetoacetate	NNP
cord-001835-0s7ok4uw	1268	21	(	(	-LRB-
cord-001835-0s7ok4uw	1268	22	MAA	MAA	NNP
cord-001835-0s7ok4uw	1268	23	)	)	-RRB-
cord-001835-0s7ok4uw	1268	24	and	and	CC
cord-001835-0s7ok4uw	1268	25	fumarylacetoacetate	fumarylacetoacetate	NNP
cord-001835-0s7ok4uw	1268	26	(	(	-LRB-
cord-001835-0s7ok4uw	1268	27	FAA	FAA	NNP
cord-001835-0s7ok4uw	1268	28	)	)	-RRB-
cord-001835-0s7ok4uw	1268	29	in	in	IN
cord-001835-0s7ok4uw	1268	30	many	many	JJ
cord-001835-0s7ok4uw	1268	31	body	body	NN
cord-001835-0s7ok4uw	1268	32	tissues	tissue	NNS
cord-001835-0s7ok4uw	1268	33	.	.	.
cord-001835-0s7ok4uw	1269	1	FAH	FAH	NNP
cord-001835-0s7ok4uw	1269	2	is	be	VBZ
cord-001835-0s7ok4uw	1269	3	mainly	mainly	RB
cord-001835-0s7ok4uw	1269	4	expressed	express	VBN
cord-001835-0s7ok4uw	1269	5	in	in	IN
cord-001835-0s7ok4uw	1269	6	hepatocytes	hepatocyte	NNS
cord-001835-0s7ok4uw	1269	7	and	and	CC
cord-001835-0s7ok4uw	1269	8	renal	renal	JJ
cord-001835-0s7ok4uw	1269	9	proximal	proximal	JJ
cord-001835-0s7ok4uw	1269	10	tubular	tubular	JJ
cord-001835-0s7ok4uw	1269	11	epithelium	epithelium	NN
cord-001835-0s7ok4uw	1269	12	.	.	.
cord-001835-0s7ok4uw	1270	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	1270	2	,	,	,
cord-001835-0s7ok4uw	1270	3	liver	liver	NN
cord-001835-0s7ok4uw	1270	4	and	and	CC
cord-001835-0s7ok4uw	1270	5	kidney	kidney	NN
cord-001835-0s7ok4uw	1270	6	are	be	VBP
cord-001835-0s7ok4uw	1270	7	the	the	DT
cord-001835-0s7ok4uw	1270	8	two	two	CD
cord-001835-0s7ok4uw	1270	9	primary	primary	JJ
cord-001835-0s7ok4uw	1270	10	organs	organ	NNS
cord-001835-0s7ok4uw	1270	11	affected	affect	VBN
cord-001835-0s7ok4uw	1270	12	by	by	IN
cord-001835-0s7ok4uw	1270	13	this	this	DT
cord-001835-0s7ok4uw	1270	14	disorder	disorder	NN
cord-001835-0s7ok4uw	1270	15	,	,	,
cord-001835-0s7ok4uw	1270	16	and	and	CC
cord-001835-0s7ok4uw	1270	17	development	development	NN
cord-001835-0s7ok4uw	1270	18	of	of	IN
cord-001835-0s7ok4uw	1270	19	hepatocellular	hepatocellular	JJ
cord-001835-0s7ok4uw	1270	20	carcinoma	carcinoma	NN
cord-001835-0s7ok4uw	1270	21	is	be	VBZ
cord-001835-0s7ok4uw	1270	22	the	the	DT
cord-001835-0s7ok4uw	1270	23	major	major	JJ
cord-001835-0s7ok4uw	1270	24	symptom	symptom	NN
cord-001835-0s7ok4uw	1270	25	.	.	.
cord-001835-0s7ok4uw	1271	1	Missense	missense	NN
cord-001835-0s7ok4uw	1271	2	mutations	mutation	NNS
cord-001835-0s7ok4uw	1271	3	leads	lead	VBZ
cord-001835-0s7ok4uw	1271	4	to	to	IN
cord-001835-0s7ok4uw	1271	5	a	a	DT
cord-001835-0s7ok4uw	1271	6	loss	loss	NN
cord-001835-0s7ok4uw	1271	7	of	of	IN
cord-001835-0s7ok4uw	1271	8	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	1271	9	efficiency	efficiency	NN
cord-001835-0s7ok4uw	1271	10	which	which	WDT
cord-001835-0s7ok4uw	1271	11	,	,	,
cord-001835-0s7ok4uw	1271	12	in	in	IN
cord-001835-0s7ok4uw	1271	13	a	a	DT
cord-001835-0s7ok4uw	1271	14	high	high	JJ
cord-001835-0s7ok4uw	1271	15	number	number	NN
cord-001835-0s7ok4uw	1271	16	of	of	IN
cord-001835-0s7ok4uw	1271	17	mutations	mutation	NNS
cord-001835-0s7ok4uw	1271	18	,	,	,
cord-001835-0s7ok4uw	1271	19	correlates	correlate	VBZ
cord-001835-0s7ok4uw	1271	20	with	with	IN
cord-001835-0s7ok4uw	1271	21	loss	loss	NN
cord-001835-0s7ok4uw	1271	22	of	of	IN
cord-001835-0s7ok4uw	1271	23	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1271	24	and	and	CC
cord-001835-0s7ok4uw	1271	25	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1271	26	stability	stability	NN
cord-001835-0s7ok4uw	1271	27	of	of	IN
cord-001835-0s7ok4uw	1271	28	the	the	DT
cord-001835-0s7ok4uw	1271	29	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1271	30	.	.	.
cord-001835-0s7ok4uw	1272	1	In	in	IN
cord-001835-0s7ok4uw	1272	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1272	3	ongoing	ongoing	JJ
cord-001835-0s7ok4uw	1272	4	project	project	NN
cord-001835-0s7ok4uw	1272	5	,	,	,
cord-001835-0s7ok4uw	1272	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	1272	7	are	be	VBP
cord-001835-0s7ok4uw	1272	8	trying	try	VBG
cord-001835-0s7ok4uw	1272	9	to	to	TO
cord-001835-0s7ok4uw	1272	10	elucidate	elucidate	VB
cord-001835-0s7ok4uw	1272	11	the	the	DT
cord-001835-0s7ok4uw	1272	12	molecular	molecular	JJ
cord-001835-0s7ok4uw	1272	13	basis	basis	NN
cord-001835-0s7ok4uw	1272	14	of	of	IN
cord-001835-0s7ok4uw	1272	15	tyrosinemia	tyrosinemia	NNP
cord-001835-0s7ok4uw	1272	16	by	by	IN
cord-001835-0s7ok4uw	1272	17	means	mean	NNS
cord-001835-0s7ok4uw	1272	18	of	of	IN
cord-001835-0s7ok4uw	1272	19	biophisical	biophisical	JJ
cord-001835-0s7ok4uw	1272	20	and	and	CC
cord-001835-0s7ok4uw	1272	21	structural	structural	JJ
cord-001835-0s7ok4uw	1272	22	characterization	characterization	NN
cord-001835-0s7ok4uw	1272	23	of	of	IN
cord-001835-0s7ok4uw	1272	24	FAH	FAH	NNP
cord-001835-0s7ok4uw	1272	25	wild	wild	JJ
cord-001835-0s7ok4uw	1272	26	type	type	NN
cord-001835-0s7ok4uw	1272	27	along	along	IN
cord-001835-0s7ok4uw	1272	28	with	with	IN
cord-001835-0s7ok4uw	1272	29	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1272	30	mutations	mutation	NNS
cord-001835-0s7ok4uw	1272	31	.	.	.
cord-001835-0s7ok4uw	1273	1	This	this	DT
cord-001835-0s7ok4uw	1273	2	knowledge	knowledge	NN
cord-001835-0s7ok4uw	1273	3	should	should	MD
cord-001835-0s7ok4uw	1273	4	help	help	VB
cord-001835-0s7ok4uw	1273	5	us	-PRON-	PRP
cord-001835-0s7ok4uw	1273	6	design	design	VB
cord-001835-0s7ok4uw	1273	7	new	new	JJ
cord-001835-0s7ok4uw	1273	8	therapies	therapy	NNS
cord-001835-0s7ok4uw	1273	9	based	base	VBN
cord-001835-0s7ok4uw	1273	10	on	on	IN
cord-001835-0s7ok4uw	1273	11	the	the	DT
cord-001835-0s7ok4uw	1273	12	identification	identification	NN
cord-001835-0s7ok4uw	1273	13	of	of	IN
cord-001835-0s7ok4uw	1273	14	pharmacological	pharmacological	JJ
cord-001835-0s7ok4uw	1273	15	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	1273	16	that	that	WDT
cord-001835-0s7ok4uw	1273	17	could	could	MD
cord-001835-0s7ok4uw	1273	18	restore	restore	VB
cord-001835-0s7ok4uw	1273	19	the	the	DT
cord-001835-0s7ok4uw	1273	20	altered	alter	VBN
cord-001835-0s7ok4uw	1273	21	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	1273	22	stability	stability	NN
cord-001835-0s7ok4uw	1273	23	of	of	IN
cord-001835-0s7ok4uw	1273	24	the	the	DT
cord-001835-0s7ok4uw	1273	25	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1273	26	.	.	.
cord-001835-0s7ok4uw	1274	1	Human	human	JJ
cord-001835-0s7ok4uw	1274	2	FAH	FAH	NNP
cord-001835-0s7ok4uw	1274	3	wild	wild	JJ
cord-001835-0s7ok4uw	1274	4	type	type	NN
cord-001835-0s7ok4uw	1274	5	and	and	CC
cord-001835-0s7ok4uw	1274	6	19	19	CD
cord-001835-0s7ok4uw	1274	7	selected	select	VBN
cord-001835-0s7ok4uw	1274	8	mutants	mutant	NNS
cord-001835-0s7ok4uw	1274	9	were	be	VBD
cord-001835-0s7ok4uw	1274	10	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	1274	11	and	and	CC
cord-001835-0s7ok4uw	1274	12	inserted	insert	VBN
cord-001835-0s7ok4uw	1274	13	in	in	IN
cord-001835-0s7ok4uw	1274	14	an	an	DT
cord-001835-0s7ok4uw	1274	15	expression	expression	NN
cord-001835-0s7ok4uw	1274	16	vector	vector	NN
cord-001835-0s7ok4uw	1274	17	for	for	IN
cord-001835-0s7ok4uw	1274	18	E.	E.	NNP
cord-001835-0s7ok4uw	1274	19	coli	coli	NNS
cord-001835-0s7ok4uw	1274	20	.	.	.
cord-001835-0s7ok4uw	1275	1	The	the	DT
cord-001835-0s7ok4uw	1275	2	proteins	protein	NNS
cord-001835-0s7ok4uw	1275	3	were	be	VBD
cord-001835-0s7ok4uw	1275	4	purified	purify	VBN
cord-001835-0s7ok4uw	1275	5	in	in	IN
cord-001835-0s7ok4uw	1275	6	a	a	DT
cord-001835-0s7ok4uw	1275	7	FPLC	FPLC	NNP
cord-001835-0s7ok4uw	1275	8	and	and	CC
cord-001835-0s7ok4uw	1275	9	,	,	,
cord-001835-0s7ok4uw	1275	10	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1275	11	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1275	12	and	and	CC
cord-001835-0s7ok4uw	1275	13	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1275	14	stability	stability	NN
cord-001835-0s7ok4uw	1275	15	investigated	investigate	VBN
cord-001835-0s7ok4uw	1275	16	using	use	VBG
cord-001835-0s7ok4uw	1275	17	circular	circular	JJ
cord-001835-0s7ok4uw	1275	18	dichroism	dichroism	NN
cord-001835-0s7ok4uw	1275	19	.	.	.
cord-001835-0s7ok4uw	1276	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1276	2	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	1276	3	results	result	NNS
cord-001835-0s7ok4uw	1276	4	confirm	confirm	VBP
cord-001835-0s7ok4uw	1276	5	the	the	DT
cord-001835-0s7ok4uw	1276	6	loss	loss	NN
cord-001835-0s7ok4uw	1276	7	of	of	IN
cord-001835-0s7ok4uw	1276	8	termodinamic	termodinamic	JJ
cord-001835-0s7ok4uw	1276	9	stability	stability	NN
cord-001835-0s7ok4uw	1276	10	of	of	IN
cord-001835-0s7ok4uw	1276	11	different	different	JJ
cord-001835-0s7ok4uw	1276	12	mutants	mutant	NNS
cord-001835-0s7ok4uw	1276	13	and	and	CC
cord-001835-0s7ok4uw	1276	14	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1276	15	variability	variability	NN
cord-001835-0s7ok4uw	1276	16	compared	compare	VBN
cord-001835-0s7ok4uw	1276	17	to	to	IN
cord-001835-0s7ok4uw	1276	18	wild	wild	JJ
cord-001835-0s7ok4uw	1276	19	type	type	NN
cord-001835-0s7ok4uw	1276	20	protein	protein	NN
cord-001835-0s7ok4uw	1276	21	.	.	.
cord-001835-0s7ok4uw	1277	1	Repulsion	repulsion	NN
cord-001835-0s7ok4uw	1277	2	between	between	IN
cord-001835-0s7ok4uw	1277	3	net	net	JJ
cord-001835-0s7ok4uw	1277	4	charges	charge	NNS
cord-001835-0s7ok4uw	1277	5	of	of	IN
cord-001835-0s7ok4uw	1277	6	subunits	subunit	NNS
cord-001835-0s7ok4uw	1277	7	during	during	IN
cord-001835-0s7ok4uw	1277	8	ferritin	ferritin	NN
cord-001835-0s7ok4uw	1277	9	assembly	assembly	NN
cord-001835-0s7ok4uw	1277	10	Daisuke	Daisuke	NNP
cord-001835-0s7ok4uw	1277	11	Sato	Sato	NNP
cord-001835-0s7ok4uw	1277	12	1	1	CD
cord-001835-0s7ok4uw	1277	13	,	,	,
cord-001835-0s7ok4uw	1277	14	Hideaki	Hideaki	NNP
cord-001835-0s7ok4uw	1277	15	Ohtomo	Ohtomo	NNP
cord-001835-0s7ok4uw	1277	16	1	1	CD
cord-001835-0s7ok4uw	1277	17	,	,	,
cord-001835-0s7ok4uw	1277	18	Atsushi	Atsushi	NNP
cord-001835-0s7ok4uw	1277	19	Kurobe	Kurobe	NNP
cord-001835-0s7ok4uw	1277	20	1	1	CD
cord-001835-0s7ok4uw	1277	21	,	,	,
cord-001835-0s7ok4uw	1277	22	Satsuki	Satsuki	NNP
cord-001835-0s7ok4uw	1277	23	Takebe	Takebe	NNP
cord-001835-0s7ok4uw	1277	24	1	1	CD
cord-001835-0s7ok4uw	1277	25	,	,	,
cord-001835-0s7ok4uw	1277	26	Yoshiteru	Yoshiteru	NNP
cord-001835-0s7ok4uw	1277	27	Yamada	Yamada	NNP
cord-001835-0s7ok4uw	1277	28	2	2	CD
cord-001835-0s7ok4uw	1277	29	,	,	,
cord-001835-0s7ok4uw	1277	30	Kazuo	Kazuo	NNP
cord-001835-0s7ok4uw	1277	31	Fujiwara	Fujiwara	NNP
cord-001835-0s7ok4uw	1277	32	1	1	CD
cord-001835-0s7ok4uw	1277	33	,	,	,
cord-001835-0s7ok4uw	1277	34	Masamichi	Masamichi	NNP
cord-001835-0s7ok4uw	1277	35	Ikeguchi	Ikeguchi	NNP
cord-001835-0s7ok4uw	1277	36	1	1	CD
cord-001835-0s7ok4uw	1277	37	1	1	CD
cord-001835-0s7ok4uw	1277	38	Department	Department	NNP
cord-001835-0s7ok4uw	1277	39	of	of	IN
cord-001835-0s7ok4uw	1277	40	Bioinformatics	Bioinformatics	NNP
cord-001835-0s7ok4uw	1277	41	,	,	,
cord-001835-0s7ok4uw	1277	42	Graduate	Graduate	NNP
cord-001835-0s7ok4uw	1277	43	School	School	NNP
cord-001835-0s7ok4uw	1277	44	of	of	IN
cord-001835-0s7ok4uw	1277	45	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	1277	46	,	,	,
cord-001835-0s7ok4uw	1277	47	Soka	Soka	NNP
cord-001835-0s7ok4uw	1277	48	University	University	NNP
cord-001835-0s7ok4uw	1277	49	,	,	,
cord-001835-0s7ok4uw	1278	1	2	2	CD
cord-001835-0s7ok4uw	1278	2	JASRI	JASRI	NNP
cord-001835-0s7ok4uw	1278	3	/	/	SYM
cord-001835-0s7ok4uw	1278	4	SPring-8	SPring-8	NNP
cord-001835-0s7ok4uw	1279	1	The	the	DT
cord-001835-0s7ok4uw	1279	2	organisms	organism	NNS
cord-001835-0s7ok4uw	1279	3	have	have	VBP
cord-001835-0s7ok4uw	1279	4	a	a	DT
cord-001835-0s7ok4uw	1279	5	lot	lot	NN
cord-001835-0s7ok4uw	1279	6	of	of	IN
cord-001835-0s7ok4uw	1279	7	spherical	spherical	JJ
cord-001835-0s7ok4uw	1279	8	shell	shell	NN
cord-001835-0s7ok4uw	1279	9	-	-	HYPH
cord-001835-0s7ok4uw	1279	10	shaped	shape	VBN
cord-001835-0s7ok4uw	1279	11	supermolecules	supermolecule	NNS
cord-001835-0s7ok4uw	1279	12	consisting	consist	VBG
cord-001835-0s7ok4uw	1279	13	of	of	IN
cord-001835-0s7ok4uw	1279	14	identical	identical	JJ
cord-001835-0s7ok4uw	1279	15	or	or	CC
cord-001835-0s7ok4uw	1279	16	distinct	distinct	JJ
cord-001835-0s7ok4uw	1279	17	subunits	subunit	NNS
cord-001835-0s7ok4uw	1279	18	(	(	-LRB-
cord-001835-0s7ok4uw	1279	19	e.g.	e.g.	RB
cord-001835-0s7ok4uw	1279	20	,	,	,
cord-001835-0s7ok4uw	1279	21	ferritin	ferritin	NN
cord-001835-0s7ok4uw	1279	22	,	,	,
cord-001835-0s7ok4uw	1279	23	virus	virus	NN
cord-001835-0s7ok4uw	1279	24	capsid	capsid	NN
cord-001835-0s7ok4uw	1279	25	,	,	,
cord-001835-0s7ok4uw	1279	26	lumazine	lumazine	JJ
cord-001835-0s7ok4uw	1279	27	synthase	synthase	NN
cord-001835-0s7ok4uw	1279	28	and	and	CC
cord-001835-0s7ok4uw	1279	29	encapsulin	encapsulin	NNP
cord-001835-0s7ok4uw	1279	30	)	)	-RRB-
cord-001835-0s7ok4uw	1279	31	.	.	.
cord-001835-0s7ok4uw	1280	1	Such	such	JJ
cord-001835-0s7ok4uw	1280	2	multimeric	multimeric	JJ
cord-001835-0s7ok4uw	1280	3	proteins	protein	NNS
cord-001835-0s7ok4uw	1280	4	spontaneously	spontaneously	RB
cord-001835-0s7ok4uw	1280	5	assemble	assemble	VBP
cord-001835-0s7ok4uw	1280	6	into	into	IN
cord-001835-0s7ok4uw	1280	7	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1280	8	native	native	JJ
cord-001835-0s7ok4uw	1280	9	structures	structure	NNS
cord-001835-0s7ok4uw	1280	10	from	from	IN
cord-001835-0s7ok4uw	1280	11	the	the	DT
cord-001835-0s7ok4uw	1280	12	subunits	subunit	NNS
cord-001835-0s7ok4uw	1280	13	to	to	TO
cord-001835-0s7ok4uw	1280	14	acquire	acquire	VB
cord-001835-0s7ok4uw	1280	15	the	the	DT
cord-001835-0s7ok4uw	1280	16	specific	specific	JJ
cord-001835-0s7ok4uw	1280	17	functions	function	NNS
cord-001835-0s7ok4uw	1280	18	.	.	.
cord-001835-0s7ok4uw	1281	1	However	however	RB
cord-001835-0s7ok4uw	1281	2	,	,	,
cord-001835-0s7ok4uw	1281	3	the	the	DT
cord-001835-0s7ok4uw	1281	4	assembly	assembly	NN
cord-001835-0s7ok4uw	1281	5	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1281	6	of	of	IN
cord-001835-0s7ok4uw	1281	7	such	such	JJ
cord-001835-0s7ok4uw	1281	8	supermolecules	supermolecule	NNS
cord-001835-0s7ok4uw	1281	9	has	have	VBZ
cord-001835-0s7ok4uw	1281	10	not	not	RB
cord-001835-0s7ok4uw	1281	11	been	be	VBN
cord-001835-0s7ok4uw	1281	12	understood	understand	VBN
cord-001835-0s7ok4uw	1281	13	in	in	IN
cord-001835-0s7ok4uw	1281	14	detail	detail	NN
cord-001835-0s7ok4uw	1281	15	.	.	.
cord-001835-0s7ok4uw	1282	1	Hence	hence	RB
cord-001835-0s7ok4uw	1282	2	,	,	,
cord-001835-0s7ok4uw	1282	3	to	to	TO
cord-001835-0s7ok4uw	1282	4	investigate	investigate	VB
cord-001835-0s7ok4uw	1282	5	the	the	DT
cord-001835-0s7ok4uw	1282	6	assembly	assembly	NN
cord-001835-0s7ok4uw	1282	7	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1282	8	is	be	VBZ
cord-001835-0s7ok4uw	1282	9	biologically	biologically	RB
cord-001835-0s7ok4uw	1282	10	important	important	JJ
cord-001835-0s7ok4uw	1282	11	.	.	.
cord-001835-0s7ok4uw	1283	1	Escherichia	escherichia	NN
cord-001835-0s7ok4uw	1283	2	coli	coli	VBZ
cord-001835-0s7ok4uw	1283	3	non	non	JJ
cord-001835-0s7ok4uw	1283	4	-	-	JJ
cord-001835-0s7ok4uw	1283	5	heme	heme	JJ
cord-001835-0s7ok4uw	1283	6	ferritin	ferritin	NN
cord-001835-0s7ok4uw	1283	7	(	(	-LRB-
cord-001835-0s7ok4uw	1283	8	Ftn	Ftn	NNP
cord-001835-0s7ok4uw	1283	9	)	)	-RRB-
cord-001835-0s7ok4uw	1283	10	consists	consist	VBZ
cord-001835-0s7ok4uw	1283	11	of	of	IN
cord-001835-0s7ok4uw	1283	12	24	24	CD
cord-001835-0s7ok4uw	1283	13	identical	identical	JJ
cord-001835-0s7ok4uw	1283	14	subunits	subunit	NNS
cord-001835-0s7ok4uw	1283	15	,	,	,
cord-001835-0s7ok4uw	1283	16	which	which	WDT
cord-001835-0s7ok4uw	1283	17	are	be	VBP
cord-001835-0s7ok4uw	1283	18	assembled	assemble	VBN
cord-001835-0s7ok4uw	1283	19	into	into	IN
cord-001835-0s7ok4uw	1283	20	a	a	DT
cord-001835-0s7ok4uw	1283	21	spherical	spherical	JJ
cord-001835-0s7ok4uw	1283	22	shell	shell	NN
cord-001835-0s7ok4uw	1283	23	-	-	HYPH
cord-001835-0s7ok4uw	1283	24	shape	shape	NN
cord-001835-0s7ok4uw	1283	25	with	with	IN
cord-001835-0s7ok4uw	1283	26	4/3/2	4/3/2	CD
cord-001835-0s7ok4uw	1283	27	symmetry	symmetry	NN
cord-001835-0s7ok4uw	1283	28	.	.	.
cord-001835-0s7ok4uw	1284	1	Ftn	Ftn	NNP
cord-001835-0s7ok4uw	1284	2	is	be	VBZ
cord-001835-0s7ok4uw	1284	3	able	able	JJ
cord-001835-0s7ok4uw	1284	4	to	to	TO
cord-001835-0s7ok4uw	1284	5	store	store	VB
cord-001835-0s7ok4uw	1284	6	iron	iron	NN
cord-001835-0s7ok4uw	1284	7	inside	inside	IN
cord-001835-0s7ok4uw	1284	8	cavity	cavity	NN
cord-001835-0s7ok4uw	1284	9	.	.	.
cord-001835-0s7ok4uw	1285	1	The	the	DT
cord-001835-0s7ok4uw	1285	2	subunit	subunit	NN
cord-001835-0s7ok4uw	1285	3	includes	include	VBZ
cord-001835-0s7ok4uw	1285	4	A	a	DT
cord-001835-0s7ok4uw	1285	5	-	-	HYPH
cord-001835-0s7ok4uw	1285	6	D	d	JJ
cord-001835-0s7ok4uw	1285	7	helices	helix	NNS
cord-001835-0s7ok4uw	1285	8	forming	form	VBG
cord-001835-0s7ok4uw	1285	9	4-helix	4-helix	CD
cord-001835-0s7ok4uw	1285	10	bundle	bundle	NN
cord-001835-0s7ok4uw	1285	11	,	,	,
cord-001835-0s7ok4uw	1285	12	a	a	DT
cord-001835-0s7ok4uw	1285	13	long	long	JJ
cord-001835-0s7ok4uw	1285	14	BC	BC	NNP
cord-001835-0s7ok4uw	1285	15	-	-	HYPH
cord-001835-0s7ok4uw	1285	16	loop	loop	NN
cord-001835-0s7ok4uw	1285	17	between	between	IN
cord-001835-0s7ok4uw	1285	18	B	b	NN
cord-001835-0s7ok4uw	1285	19	and	and	CC
cord-001835-0s7ok4uw	1285	20	C	C	NNP
cord-001835-0s7ok4uw	1285	21	-	-	HYPH
cord-001835-0s7ok4uw	1285	22	helices	helix	NNS
cord-001835-0s7ok4uw	1285	23	and	and	CC
cord-001835-0s7ok4uw	1285	24	a	a	DT
cord-001835-0s7ok4uw	1285	25	short	short	JJ
cord-001835-0s7ok4uw	1285	26	E	e	NN
cord-001835-0s7ok4uw	1285	27	-	-	NN
cord-001835-0s7ok4uw	1285	28	helix	helix	NN
cord-001835-0s7ok4uw	1285	29	at	at	IN
cord-001835-0s7ok4uw	1285	30	the	the	DT
cord-001835-0s7ok4uw	1285	31	C	C	NNP
cord-001835-0s7ok4uw	1285	32	-	-	HYPH
cord-001835-0s7ok4uw	1285	33	terminal	terminal	NN
cord-001835-0s7ok4uw	1285	34	.	.	.
cord-001835-0s7ok4uw	1286	1	Ftn	Ftn	NNP
cord-001835-0s7ok4uw	1286	2	dissociates	dissociate	VBZ
cord-001835-0s7ok4uw	1286	3	into	into	IN
cord-001835-0s7ok4uw	1286	4	dimers	dimer	NNS
cord-001835-0s7ok4uw	1286	5	at	at	IN
cord-001835-0s7ok4uw	1286	6	acidic	acidic	JJ
cord-001835-0s7ok4uw	1286	7	pH.	ph.	NN
cord-001835-0s7ok4uw	1287	1	The	the	DT
cord-001835-0s7ok4uw	1287	2	dimer	dimer	NN
cord-001835-0s7ok4uw	1287	3	was	be	VBD
cord-001835-0s7ok4uw	1287	4	shown	show	VBN
cord-001835-0s7ok4uw	1287	5	to	to	TO
cord-001835-0s7ok4uw	1287	6	maintain	maintain	VB
cord-001835-0s7ok4uw	1287	7	the	the	DT
cord-001835-0s7ok4uw	1287	8	native	native	JJ
cord-001835-0s7ok4uw	1287	9	-	-	HYPH
cord-001835-0s7ok4uw	1287	10	like	like	JJ
cord-001835-0s7ok4uw	1287	11	secondary	secondary	JJ
cord-001835-0s7ok4uw	1287	12	and	and	CC
cord-001835-0s7ok4uw	1287	13	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	1287	14	structures	structure	NNS
cord-001835-0s7ok4uw	1287	15	by	by	IN
cord-001835-0s7ok4uw	1287	16	circular	circular	JJ
cord-001835-0s7ok4uw	1287	17	dichroism	dichroism	NN
cord-001835-0s7ok4uw	1287	18	spectra	spectra	JJ
cord-001835-0s7ok4uw	1287	19	and	and	CC
cord-001835-0s7ok4uw	1287	20	small	small	JJ
cord-001835-0s7ok4uw	1287	21	angle	angle	NN
cord-001835-0s7ok4uw	1287	22	X	x	NN
cord-001835-0s7ok4uw	1287	23	-	-	NN
cord-001835-0s7ok4uw	1287	24	ray	ray	NN
cord-001835-0s7ok4uw	1287	25	scattering	scattering	NN
cord-001835-0s7ok4uw	1287	26	(	(	-LRB-
cord-001835-0s7ok4uw	1287	27	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	1287	28	)	)	-RRB-
cord-001835-0s7ok4uw	1287	29	.	.	.
cord-001835-0s7ok4uw	1288	1	The	the	DT
cord-001835-0s7ok4uw	1288	2	acid	acid	NN
cord-001835-0s7ok4uw	1288	3	-	-	HYPH
cord-001835-0s7ok4uw	1288	4	dissociated	dissociated	JJ
cord-001835-0s7ok4uw	1288	5	Ftn	Ftn	NNP
cord-001835-0s7ok4uw	1288	6	is	be	VBZ
cord-001835-0s7ok4uw	1288	7	able	able	JJ
cord-001835-0s7ok4uw	1288	8	to	to	TO
cord-001835-0s7ok4uw	1288	9	reassemble	reassemble	VB
cord-001835-0s7ok4uw	1288	10	into	into	IN
cord-001835-0s7ok4uw	1288	11	the	the	DT
cord-001835-0s7ok4uw	1288	12	native	native	JJ
cord-001835-0s7ok4uw	1288	13	structure	structure	NN
cord-001835-0s7ok4uw	1288	14	when	when	WRB
cord-001835-0s7ok4uw	1288	15	pH	pH	NNP
cord-001835-0s7ok4uw	1288	16	increases	increase	NNS
cord-001835-0s7ok4uw	1288	17	.	.	.
cord-001835-0s7ok4uw	1289	1	To	to	TO
cord-001835-0s7ok4uw	1289	2	clarify	clarify	VB
cord-001835-0s7ok4uw	1289	3	Ftn	Ftn	NNP
cord-001835-0s7ok4uw	1289	4	assembly	assembly	NN
cord-001835-0s7ok4uw	1289	5	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1289	6	,	,	,
cord-001835-0s7ok4uw	1289	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	1289	8	performed	perform	VBD
cord-001835-0s7ok4uw	1289	9	the	the	DT
cord-001835-0s7ok4uw	1289	10	stopped	stop	VBN
cord-001835-0s7ok4uw	1289	11	-	-	HYPH
cord-001835-0s7ok4uw	1289	12	flow	flow	NN
cord-001835-0s7ok4uw	1289	13	time	time	NN
cord-001835-0s7ok4uw	1289	14	-	-	HYPH
cord-001835-0s7ok4uw	1289	15	resolved	resolve	VBN
cord-001835-0s7ok4uw	1289	16	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	1289	17	(	(	-LRB-
cord-001835-0s7ok4uw	1289	18	TR	tr	NN
cord-001835-0s7ok4uw	1289	19	-	-	HYPH
cord-001835-0s7ok4uw	1289	20	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	1289	21	)	)	-RRB-
cord-001835-0s7ok4uw	1289	22	experiments	experiment	NNS
cord-001835-0s7ok4uw	1289	23	.	.	.
cord-001835-0s7ok4uw	1290	1	The	the	DT
cord-001835-0s7ok4uw	1290	2	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	1290	3	profiles	profile	NNS
cord-001835-0s7ok4uw	1290	4	could	could	MD
cord-001835-0s7ok4uw	1290	5	be	be	VB
cord-001835-0s7ok4uw	1290	6	acquired	acquire	VBN
cord-001835-0s7ok4uw	1290	7	every	every	DT
cord-001835-0s7ok4uw	1290	8	15	15	CD
cord-001835-0s7ok4uw	1290	9	ms	m	NNS
cord-001835-0s7ok4uw	1290	10	after	after	IN
cord-001835-0s7ok4uw	1290	11	the	the	DT
cord-001835-0s7ok4uw	1290	12	initiation	initiation	NN
cord-001835-0s7ok4uw	1290	13	of	of	IN
cord-001835-0s7ok4uw	1290	14	reassembly	reassembly	NN
cord-001835-0s7ok4uw	1290	15	.	.	.
cord-001835-0s7ok4uw	1291	1	The	the	DT
cord-001835-0s7ok4uw	1291	2	initial	initial	JJ
cord-001835-0s7ok4uw	1291	3	velocity	velocity	NN
cord-001835-0s7ok4uw	1291	4	calculated	calculate	VBN
cord-001835-0s7ok4uw	1291	5	from	from	IN
cord-001835-0s7ok4uw	1291	6	the	the	DT
cord-001835-0s7ok4uw	1291	7	forward	forward	JJ
cord-001835-0s7ok4uw	1291	8	scattering	scatter	VBG
cord-001835-0s7ok4uw	1291	9	intensity	intensity	NN
cord-001835-0s7ok4uw	1291	10	increment	increment	NN
cord-001835-0s7ok4uw	1291	11	was	be	VBD
cord-001835-0s7ok4uw	1291	12	proportional	proportional	JJ
cord-001835-0s7ok4uw	1291	13	to	to	IN
cord-001835-0s7ok4uw	1291	14	the	the	DT
cord-001835-0s7ok4uw	1291	15	square	square	NN
cord-001835-0s7ok4uw	1291	16	of	of	IN
cord-001835-0s7ok4uw	1291	17	the	the	DT
cord-001835-0s7ok4uw	1291	18	protein	protein	NN
cord-001835-0s7ok4uw	1291	19	concentration	concentration	NN
cord-001835-0s7ok4uw	1291	20	,	,	,
cord-001835-0s7ok4uw	1291	21	implying	imply	VBG
cord-001835-0s7ok4uw	1291	22	that	that	IN
cord-001835-0s7ok4uw	1291	23	the	the	DT
cord-001835-0s7ok4uw	1291	24	reaction	reaction	NN
cord-001835-0s7ok4uw	1291	25	is	be	VBZ
cord-001835-0s7ok4uw	1291	26	second	second	JJ
cord-001835-0s7ok4uw	1291	27	-	-	HYPH
cord-001835-0s7ok4uw	1291	28	order	order	NN
cord-001835-0s7ok4uw	1291	29	.	.	.
cord-001835-0s7ok4uw	1292	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1292	2	propose	propose	VBP
cord-001835-0s7ok4uw	1292	3	the	the	DT
cord-001835-0s7ok4uw	1292	4	sequential	sequential	JJ
cord-001835-0s7ok4uw	1292	5	bimolecular	bimolecular	NNP
cord-001835-0s7ok4uw	1292	6	reaction	reaction	NN
cord-001835-0s7ok4uw	1292	7	,	,	,
cord-001835-0s7ok4uw	1292	8	in	in	IN
cord-001835-0s7ok4uw	1292	9	which	which	WDT
cord-001835-0s7ok4uw	1292	10	two	two	CD
cord-001835-0s7ok4uw	1292	11	dimers	dimer	NNS
cord-001835-0s7ok4uw	1292	12	bind	bind	VBP
cord-001835-0s7ok4uw	1292	13	to	to	TO
cord-001835-0s7ok4uw	1292	14	form	form	VB
cord-001835-0s7ok4uw	1292	15	tetramer	tetramer	NN
cord-001835-0s7ok4uw	1292	16	,	,	,
cord-001835-0s7ok4uw	1292	17	then	then	RB
cord-001835-0s7ok4uw	1292	18	another	another	DT
cord-001835-0s7ok4uw	1292	19	dimer	dimer	NN
cord-001835-0s7ok4uw	1292	20	attaches	attach	VBZ
cord-001835-0s7ok4uw	1292	21	to	to	IN
cord-001835-0s7ok4uw	1292	22	the	the	DT
cord-001835-0s7ok4uw	1292	23	tetramer	tetramer	NN
cord-001835-0s7ok4uw	1292	24	to	to	TO
cord-001835-0s7ok4uw	1292	25	form	form	VB
cord-001835-0s7ok4uw	1292	26	a	a	DT
cord-001835-0s7ok4uw	1292	27	hexamer	hexamer	NN
cord-001835-0s7ok4uw	1292	28	,	,	,
cord-001835-0s7ok4uw	1292	29	and	and	CC
cord-001835-0s7ok4uw	1292	30	so	so	RB
cord-001835-0s7ok4uw	1292	31	on	on	RB
cord-001835-0s7ok4uw	1292	32	.	.	.
cord-001835-0s7ok4uw	1293	1	The	the	DT
cord-001835-0s7ok4uw	1293	2	assembly	assembly	NN
cord-001835-0s7ok4uw	1293	3	rate	rate	NN
cord-001835-0s7ok4uw	1293	4	depended	depend	VBD
cord-001835-0s7ok4uw	1293	5	on	on	IN
cord-001835-0s7ok4uw	1293	6	pH	ph	NN
cord-001835-0s7ok4uw	1293	7	and	and	CC
cord-001835-0s7ok4uw	1293	8	ion	ion	NN
cord-001835-0s7ok4uw	1293	9	strength	strength	NN
cord-001835-0s7ok4uw	1293	10	,	,	,
cord-001835-0s7ok4uw	1293	11	indicating	indicate	VBG
cord-001835-0s7ok4uw	1293	12	that	that	IN
cord-001835-0s7ok4uw	1293	13	the	the	DT
cord-001835-0s7ok4uw	1293	14	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	1293	15	interaction	interaction	NN
cord-001835-0s7ok4uw	1293	16	plays	play	VBZ
cord-001835-0s7ok4uw	1293	17	an	an	DT
cord-001835-0s7ok4uw	1293	18	important	important	JJ
cord-001835-0s7ok4uw	1293	19	role	role	NN
cord-001835-0s7ok4uw	1293	20	in	in	IN
cord-001835-0s7ok4uw	1293	21	the	the	DT
cord-001835-0s7ok4uw	1293	22	assembly	assembly	NN
cord-001835-0s7ok4uw	1293	23	reaction	reaction	NN
cord-001835-0s7ok4uw	1293	24	.	.	.
cord-001835-0s7ok4uw	1294	1	The	the	DT
cord-001835-0s7ok4uw	1294	2	assembly	assembly	NN
cord-001835-0s7ok4uw	1294	3	rate	rate	NN
cord-001835-0s7ok4uw	1294	4	decreased	decrease	VBD
cord-001835-0s7ok4uw	1294	5	with	with	IN
cord-001835-0s7ok4uw	1294	6	increasing	increase	VBG
cord-001835-0s7ok4uw	1294	7	pH	ph	NN
cord-001835-0s7ok4uw	1294	8	in	in	IN
cord-001835-0s7ok4uw	1294	9	the	the	DT
cord-001835-0s7ok4uw	1294	10	range	range	NN
cord-001835-0s7ok4uw	1294	11	from	from	IN
cord-001835-0s7ok4uw	1294	12	6.0	6.0	CD
cord-001835-0s7ok4uw	1294	13	to	to	IN
cord-001835-0s7ok4uw	1294	14	8.0	8.0	CD
cord-001835-0s7ok4uw	1294	15	and	and	CC
cord-001835-0s7ok4uw	1294	16	increased	increase	VBD
cord-001835-0s7ok4uw	1294	17	with	with	IN
cord-001835-0s7ok4uw	1294	18	increasing	increase	VBG
cord-001835-0s7ok4uw	1294	19	NaCl	nacl	NN
cord-001835-0s7ok4uw	1294	20	concentration	concentration	NN
cord-001835-0s7ok4uw	1294	21	.	.	.
cord-001835-0s7ok4uw	1295	1	This	this	DT
cord-001835-0s7ok4uw	1295	2	indicates	indicate	VBZ
cord-001835-0s7ok4uw	1295	3	that	that	IN
cord-001835-0s7ok4uw	1295	4	there	there	EX
cord-001835-0s7ok4uw	1295	5	are	be	VBP
cord-001835-0s7ok4uw	1295	6	repulsive	repulsive	JJ
cord-001835-0s7ok4uw	1295	7	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	1295	8	interactions	interaction	NNS
cord-001835-0s7ok4uw	1295	9	between	between	IN
cord-001835-0s7ok4uw	1295	10	assembly	assembly	NN
cord-001835-0s7ok4uw	1295	11	units	unit	NNS
cord-001835-0s7ok4uw	1295	12	and	and	CC
cord-001835-0s7ok4uw	1295	13	that	that	IN
cord-001835-0s7ok4uw	1295	14	they	-PRON-	PRP
cord-001835-0s7ok4uw	1295	15	increases	increase	VBZ
cord-001835-0s7ok4uw	1295	16	with	with	IN
cord-001835-0s7ok4uw	1295	17	increasing	increase	VBG
cord-001835-0s7ok4uw	1295	18	pH	ph	NN
cord-001835-0s7ok4uw	1295	19	from	from	IN
cord-001835-0s7ok4uw	1295	20	6.0	6.0	CD
cord-001835-0s7ok4uw	1295	21	to	to	IN
cord-001835-0s7ok4uw	1295	22	8.0	8.0	CD
cord-001835-0s7ok4uw	1295	23	.	.	.
cord-001835-0s7ok4uw	1296	1	A	a	DT
cord-001835-0s7ok4uw	1296	2	possible	possible	JJ
cord-001835-0s7ok4uw	1296	3	interaction	interaction	NN
cord-001835-0s7ok4uw	1296	4	is	be	VBZ
cord-001835-0s7ok4uw	1296	5	the	the	DT
cord-001835-0s7ok4uw	1296	6	repulsion	repulsion	NN
cord-001835-0s7ok4uw	1296	7	between	between	IN
cord-001835-0s7ok4uw	1296	8	net	net	JJ
cord-001835-0s7ok4uw	1296	9	charges	charge	NNS
cord-001835-0s7ok4uw	1296	10	of	of	IN
cord-001835-0s7ok4uw	1296	11	dimers	dimer	NNS
cord-001835-0s7ok4uw	1296	12	since	since	IN
cord-001835-0s7ok4uw	1296	13	pI	pI	NNP
cord-001835-0s7ok4uw	1296	14	of	of	IN
cord-001835-0s7ok4uw	1296	15	Ftn	Ftn	NNP
cord-001835-0s7ok4uw	1296	16	is	be	VBZ
cord-001835-0s7ok4uw	1296	17	expected	expect	VBN
cord-001835-0s7ok4uw	1296	18	to	to	TO
cord-001835-0s7ok4uw	1296	19	be	be	VB
cord-001835-0s7ok4uw	1296	20	4.6	4.6	CD
cord-001835-0s7ok4uw	1296	21	.	.	.
cord-001835-0s7ok4uw	1297	1	To	to	TO
cord-001835-0s7ok4uw	1297	2	test	test	VB
cord-001835-0s7ok4uw	1297	3	this	this	DT
cord-001835-0s7ok4uw	1297	4	possibility	possibility	NN
cord-001835-0s7ok4uw	1297	5	,	,	,
cord-001835-0s7ok4uw	1297	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	1297	7	made	make	VBD
cord-001835-0s7ok4uw	1297	8	several	several	JJ
cord-001835-0s7ok4uw	1297	9	mutants	mutant	NNS
cord-001835-0s7ok4uw	1297	10	with	with	IN
cord-001835-0s7ok4uw	1297	11	different	different	JJ
cord-001835-0s7ok4uw	1297	12	net	net	JJ
cord-001835-0s7ok4uw	1297	13	charges	charge	NNS
cord-001835-0s7ok4uw	1297	14	.	.	.
cord-001835-0s7ok4uw	1298	1	As	as	IN
cord-001835-0s7ok4uw	1298	2	mutational	mutational	JJ
cord-001835-0s7ok4uw	1298	3	sites	site	NNS
cord-001835-0s7ok4uw	1298	4	,	,	,
cord-001835-0s7ok4uw	1298	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1298	6	selected	select	VBD
cord-001835-0s7ok4uw	1298	7	charged	charge	VBD
cord-001835-0s7ok4uw	1298	8	residues	residue	NNS
cord-001835-0s7ok4uw	1298	9	that	that	WDT
cord-001835-0s7ok4uw	1298	10	are	be	VBP
cord-001835-0s7ok4uw	1298	11	far	far	RB
cord-001835-0s7ok4uw	1298	12	from	from	IN
cord-001835-0s7ok4uw	1298	13	the	the	DT
cord-001835-0s7ok4uw	1298	14	subunit	subunit	NN
cord-001835-0s7ok4uw	1298	15	interface	interface	NN
cord-001835-0s7ok4uw	1298	16	.	.	.
cord-001835-0s7ok4uw	1299	1	Selected	select	VBN
cord-001835-0s7ok4uw	1299	2	sites	site	NNS
cord-001835-0s7ok4uw	1299	3	were	be	VBD
cord-001835-0s7ok4uw	1299	4	Glu5	Glu5	VBN
cord-001835-0s7ok4uw	1299	5	,	,	,
cord-001835-0s7ok4uw	1299	6	Glu8	Glu8	NNP
cord-001835-0s7ok4uw	1299	7	,	,	,
cord-001835-0s7ok4uw	1299	8	Glu12	Glu12	NNP
cord-001835-0s7ok4uw	1299	9	,	,	,
cord-001835-0s7ok4uw	1299	10	Glu85	Glu85	NNP
cord-001835-0s7ok4uw	1299	11	and	and	CC
cord-001835-0s7ok4uw	1299	12	Glu89	Glu89	NNP
cord-001835-0s7ok4uw	1299	13	.	.	.
cord-001835-0s7ok4uw	1300	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1300	2	constructed	construct	VBD
cord-001835-0s7ok4uw	1300	3	the	the	DT
cord-001835-0s7ok4uw	1300	4	mutants	mutant	NNS
cord-001835-0s7ok4uw	1300	5	with	with	IN
cord-001835-0s7ok4uw	1300	6	one	one	CD
cord-001835-0s7ok4uw	1300	7	,	,	,
cord-001835-0s7ok4uw	1300	8	two	two	CD
cord-001835-0s7ok4uw	1300	9	,	,	,
cord-001835-0s7ok4uw	1300	10	three	three	CD
cord-001835-0s7ok4uw	1300	11	or	or	CC
cord-001835-0s7ok4uw	1300	12	four	four	CD
cord-001835-0s7ok4uw	1300	13	Glu	Glu	NNP
cord-001835-0s7ok4uw	1300	14	-	-	HYPH
cord-001835-0s7ok4uw	1300	15	>	>	XX
cord-001835-0s7ok4uw	1301	1	Gln	Gln	NNP
cord-001835-0s7ok4uw	1301	2	substitutions	substitution	NNS
cord-001835-0s7ok4uw	1301	3	of	of	IN
cord-001835-0s7ok4uw	1301	4	selected	select	VBN
cord-001835-0s7ok4uw	1301	5	sites	site	NNS
cord-001835-0s7ok4uw	1301	6	.	.	.
cord-001835-0s7ok4uw	1302	1	The	the	DT
cord-001835-0s7ok4uw	1302	2	structures	structure	NNS
cord-001835-0s7ok4uw	1302	3	of	of	IN
cord-001835-0s7ok4uw	1302	4	those	those	DT
cord-001835-0s7ok4uw	1302	5	mutants	mutant	NNS
cord-001835-0s7ok4uw	1302	6	were	be	VBD
cord-001835-0s7ok4uw	1302	7	similar	similar	JJ
cord-001835-0s7ok4uw	1302	8	to	to	IN
cord-001835-0s7ok4uw	1302	9	that	that	DT
cord-001835-0s7ok4uw	1302	10	of	of	IN
cord-001835-0s7ok4uw	1302	11	wild	wild	JJ
cord-001835-0s7ok4uw	1302	12	-	-	HYPH
cord-001835-0s7ok4uw	1302	13	type	type	NN
cord-001835-0s7ok4uw	1302	14	Ftn	Ftn	NNP
cord-001835-0s7ok4uw	1302	15	.	.	.
cord-001835-0s7ok4uw	1303	1	If	if	IN
cord-001835-0s7ok4uw	1303	2	aforementioned	aforementioned	JJ
cord-001835-0s7ok4uw	1303	3	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	1303	4	is	be	VBZ
cord-001835-0s7ok4uw	1303	5	correct	correct	JJ
cord-001835-0s7ok4uw	1303	6	,	,	,
cord-001835-0s7ok4uw	1303	7	the	the	DT
cord-001835-0s7ok4uw	1303	8	assembly	assembly	NN
cord-001835-0s7ok4uw	1303	9	rate	rate	NN
cord-001835-0s7ok4uw	1303	10	is	be	VBZ
cord-001835-0s7ok4uw	1303	11	expected	expect	VBN
cord-001835-0s7ok4uw	1303	12	to	to	TO
cord-001835-0s7ok4uw	1303	13	increase	increase	VB
cord-001835-0s7ok4uw	1303	14	with	with	IN
cord-001835-0s7ok4uw	1303	15	increasing	increase	VBG
cord-001835-0s7ok4uw	1303	16	the	the	DT
cord-001835-0s7ok4uw	1303	17	number	number	NN
cord-001835-0s7ok4uw	1303	18	of	of	IN
cord-001835-0s7ok4uw	1303	19	substitution	substitution	NN
cord-001835-0s7ok4uw	1303	20	.	.	.
cord-001835-0s7ok4uw	1304	1	The	the	DT
cord-001835-0s7ok4uw	1304	2	result	result	NN
cord-001835-0s7ok4uw	1304	3	agreed	agree	VBD
cord-001835-0s7ok4uw	1304	4	well	well	RB
cord-001835-0s7ok4uw	1304	5	with	with	IN
cord-001835-0s7ok4uw	1304	6	this	this	DT
cord-001835-0s7ok4uw	1304	7	expectation	expectation	NN
cord-001835-0s7ok4uw	1304	8	and	and	CC
cord-001835-0s7ok4uw	1304	9	strongly	strongly	RB
cord-001835-0s7ok4uw	1304	10	suggested	suggest	VBD
cord-001835-0s7ok4uw	1304	11	that	that	IN
cord-001835-0s7ok4uw	1304	12	the	the	DT
cord-001835-0s7ok4uw	1304	13	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	1304	14	repulsion	repulsion	NN
cord-001835-0s7ok4uw	1304	15	between	between	IN
cord-001835-0s7ok4uw	1304	16	dimers	dimer	NNS
cord-001835-0s7ok4uw	1304	17	is	be	VBZ
cord-001835-0s7ok4uw	1304	18	an	an	DT
cord-001835-0s7ok4uw	1304	19	important	important	JJ
cord-001835-0s7ok4uw	1304	20	factor	factor	NN
cord-001835-0s7ok4uw	1304	21	determining	determine	VBG
cord-001835-0s7ok4uw	1304	22	the	the	DT
cord-001835-0s7ok4uw	1304	23	assembly	assembly	NN
cord-001835-0s7ok4uw	1304	24	rate	rate	NN
cord-001835-0s7ok4uw	1304	25	of	of	IN
cord-001835-0s7ok4uw	1304	26	Ftn	Ftn	NNP
cord-001835-0s7ok4uw	1304	27	.	.	.
cord-001835-0s7ok4uw	1305	1	Improved	improved	JJ
cord-001835-0s7ok4uw	1305	2	modeling	modeling	NN
cord-001835-0s7ok4uw	1305	3	of	of	IN
cord-001835-0s7ok4uw	1305	4	protein	protein	NN
cord-001835-0s7ok4uw	1305	5	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1305	6	rates	rate	NNS
cord-001835-0s7ok4uw	1305	7	and	and	CC
cord-001835-0s7ok4uw	1305	8	pathways	pathway	NNS
cord-001835-0s7ok4uw	1305	9	through	through	IN
cord-001835-0s7ok4uw	1305	10	solvation	solvation	NN
cord-001835-0s7ok4uw	1305	11	and	and	CC
cord-001835-0s7ok4uw	1305	12	modeling	modeling	NN
cord-001835-0s7ok4uw	1305	13	of	of	IN
cord-001835-0s7ok4uw	1305	14	beta	beta	NN
cord-001835-0s7ok4uw	1305	15	-	-	HYPH
cord-001835-0s7ok4uw	1305	16	barrels	barrel	NNS
cord-001835-0s7ok4uw	1305	17	Benjamin	Benjamin	NNP
cord-001835-0s7ok4uw	1305	18	Walcott	Walcott	NNP
cord-001835-0s7ok4uw	1305	19	1,2	1,2	CD
cord-001835-0s7ok4uw	1306	1	,	,	,
cord-001835-0s7ok4uw	1306	2	Lu	Lu	NNP
cord-001835-0s7ok4uw	1306	3	ıs	ı	VBZ
cord-001835-0s7ok4uw	1306	4	Garreta	Garreta	NNP
cord-001835-0s7ok4uw	1306	5	3	3	CD
cord-001835-0s7ok4uw	1306	6	,	,	,
cord-001835-0s7ok4uw	1306	7	Christopher	Christopher	NNP
cord-001835-0s7ok4uw	1306	8	Bystroff	Bystroff	NNP
cord-001835-0s7ok4uw	1306	9	1,2,4	1,2,4	CD
cord-001835-0s7ok4uw	1306	10	1	1	CD
cord-001835-0s7ok4uw	1306	11	Department	Department	NNP
cord-001835-0s7ok4uw	1306	12	of	of	IN
cord-001835-0s7ok4uw	1306	13	Biology	Biology	NNP
cord-001835-0s7ok4uw	1306	14	,	,	,
cord-001835-0s7ok4uw	1306	15	Rensselaer	Rensselaer	NNP
cord-001835-0s7ok4uw	1306	16	Polytechnic	Polytechnic	NNP
cord-001835-0s7ok4uw	1306	17	Institute	Institute	NNP
cord-001835-0s7ok4uw	1306	18	,	,	,
cord-001835-0s7ok4uw	1306	19	2	2	CD
cord-001835-0s7ok4uw	1306	20	Center	Center	NNP
cord-001835-0s7ok4uw	1306	21	for	for	IN
cord-001835-0s7ok4uw	1306	22	Biotechnology	Biotechnology	NNP
cord-001835-0s7ok4uw	1306	23	and	and	CC
cord-001835-0s7ok4uw	1306	24	Interdisciplinary	Interdisciplinary	NNP
cord-001835-0s7ok4uw	1306	25	Studies	Studies	NNPS
cord-001835-0s7ok4uw	1306	26	,	,	,
cord-001835-0s7ok4uw	1306	27	3	3	CD
cord-001835-0s7ok4uw	1306	28	Department	Department	NNP
cord-001835-0s7ok4uw	1306	29	of	of	IN
cord-001835-0s7ok4uw	1306	30	Computer	Computer	NNP
cord-001835-0s7ok4uw	1306	31	Science	Science	NNP
cord-001835-0s7ok4uw	1306	32	,	,	,
cord-001835-0s7ok4uw	1306	33	Universdad	Universdad	NNP
cord-001835-0s7ok4uw	1306	34	del	del	NNP
cord-001835-0s7ok4uw	1306	35	Valle	Valle	NNP
cord-001835-0s7ok4uw	1306	36	,	,	,
cord-001835-0s7ok4uw	1306	37	4	4	CD
cord-001835-0s7ok4uw	1306	38	Department	Department	NNP
cord-001835-0s7ok4uw	1306	39	of	of	IN
cord-001835-0s7ok4uw	1306	40	Computer	Computer	NNP
cord-001835-0s7ok4uw	1306	41	Science	Science	NNP
cord-001835-0s7ok4uw	1306	42	,	,	,
cord-001835-0s7ok4uw	1307	1	Rensselaer	Rensselaer	NNP
cord-001835-0s7ok4uw	1307	2	Polytechnic	Polytechnic	NNP
cord-001835-0s7ok4uw	1307	3	Intitute	Intitute	NNP
cord-001835-0s7ok4uw	1308	1	An	an	DT
cord-001835-0s7ok4uw	1308	2	understanding	understanding	NN
cord-001835-0s7ok4uw	1308	3	of	of	IN
cord-001835-0s7ok4uw	1308	4	the	the	DT
cord-001835-0s7ok4uw	1308	5	folding	folding	NN
cord-001835-0s7ok4uw	1308	6	and	and	CC
cord-001835-0s7ok4uw	1308	7	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1308	8	pathways	pathway	NNS
cord-001835-0s7ok4uw	1308	9	of	of	IN
cord-001835-0s7ok4uw	1308	10	proteins	protein	NNS
cord-001835-0s7ok4uw	1308	11	is	be	VBZ
cord-001835-0s7ok4uw	1308	12	integral	integral	JJ
cord-001835-0s7ok4uw	1308	13	to	to	IN
cord-001835-0s7ok4uw	1308	14	improving	improve	VBG
cord-001835-0s7ok4uw	1308	15	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1308	16	ability	ability	NN
cord-001835-0s7ok4uw	1308	17	to	to	TO
cord-001835-0s7ok4uw	1308	18	associate	associate	VB
cord-001835-0s7ok4uw	1308	19	the	the	DT
cord-001835-0s7ok4uw	1308	20	structural	structural	JJ
cord-001835-0s7ok4uw	1308	21	impact	impact	NN
cord-001835-0s7ok4uw	1308	22	of	of	IN
cord-001835-0s7ok4uw	1308	23	point	point	NN
cord-001835-0s7ok4uw	1308	24	mutations	mutation	NNS
cord-001835-0s7ok4uw	1308	25	and	and	CC
cord-001835-0s7ok4uw	1308	26	disease	disease	NN
cord-001835-0s7ok4uw	1308	27	etiology	etiology	NN
cord-001835-0s7ok4uw	1308	28	.	.	.
cord-001835-0s7ok4uw	1309	1	Information	information	NN
cord-001835-0s7ok4uw	1309	2	gained	gain	VBN
cord-001835-0s7ok4uw	1309	3	here	here	RB
cord-001835-0s7ok4uw	1309	4	can	can	MD
cord-001835-0s7ok4uw	1309	5	also	also	RB
cord-001835-0s7ok4uw	1309	6	be	be	VB
cord-001835-0s7ok4uw	1309	7	used	use	VBN
cord-001835-0s7ok4uw	1309	8	for	for	IN
cord-001835-0s7ok4uw	1309	9	protein	protein	NN
cord-001835-0s7ok4uw	1309	10	structure	structure	NN
cord-001835-0s7ok4uw	1309	11	prediction	prediction	NN
cord-001835-0s7ok4uw	1309	12	and	and	CC
cord-001835-0s7ok4uw	1309	13	design	design	NN
cord-001835-0s7ok4uw	1309	14	.	.	.
cord-001835-0s7ok4uw	1310	1	To	to	TO
cord-001835-0s7ok4uw	1310	2	model	model	VB
cord-001835-0s7ok4uw	1310	3	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1310	4	pathways	pathway	NNS
cord-001835-0s7ok4uw	1310	5	in	in	IN
cord-001835-0s7ok4uw	1310	6	proteins	protein	NNS
cord-001835-0s7ok4uw	1310	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	1310	8	utilize	utilize	VBP
cord-001835-0s7ok4uw	1310	9	a	a	DT
cord-001835-0s7ok4uw	1310	10	computational	computational	JJ
cord-001835-0s7ok4uw	1310	11	method	method	NN
cord-001835-0s7ok4uw	1310	12	called	call	VBN
cord-001835-0s7ok4uw	1310	13	GeoFold	GeoFold	NNP
cord-001835-0s7ok4uw	1310	14	.	.	.
cord-001835-0s7ok4uw	1311	1	This	this	DT
cord-001835-0s7ok4uw	1311	2	approach	approach	NN
cord-001835-0s7ok4uw	1311	3	uses	use	VBZ
cord-001835-0s7ok4uw	1311	4	recursive	recursive	JJ
cord-001835-0s7ok4uw	1311	5	hierarchical	hierarchical	JJ
cord-001835-0s7ok4uw	1311	6	partitioning	partitioning	NN
cord-001835-0s7ok4uw	1311	7	of	of	IN
cord-001835-0s7ok4uw	1311	8	protein	protein	NN
cord-001835-0s7ok4uw	1311	9	structure	structure	NN
cord-001835-0s7ok4uw	1311	10	and	and	CC
cord-001835-0s7ok4uw	1311	11	finite	finite	JJ
cord-001835-0s7ok4uw	1311	12	elements	element	NNS
cord-001835-0s7ok4uw	1311	13	simulation	simulation	NN
cord-001835-0s7ok4uw	1311	14	.	.	.
cord-001835-0s7ok4uw	1312	1	GeoFold	GeoFold	NNP
cord-001835-0s7ok4uw	1312	2	considers	consider	VBZ
cord-001835-0s7ok4uw	1312	3	three	three	CD
cord-001835-0s7ok4uw	1312	4	types	type	NNS
cord-001835-0s7ok4uw	1312	5	of	of	IN
cord-001835-0s7ok4uw	1312	6	partitioning	partitioning	NN
cord-001835-0s7ok4uw	1312	7	operations	operation	NNS
cord-001835-0s7ok4uw	1312	8	:	:	:
cord-001835-0s7ok4uw	1312	9	translational	translational	JJ
cord-001835-0s7ok4uw	1312	10	motion	motion	NN
cord-001835-0s7ok4uw	1312	11	(	(	-LRB-
cord-001835-0s7ok4uw	1312	12	break	break	NN
cord-001835-0s7ok4uw	1312	13	)	)	-RRB-
cord-001835-0s7ok4uw	1312	14	,	,	,
cord-001835-0s7ok4uw	1312	15	single	single	JJ
cord-001835-0s7ok4uw	1312	16	point	point	NN
cord-001835-0s7ok4uw	1312	17	revolute	revolute	JJ
cord-001835-0s7ok4uw	1312	18	joints	joint	NNS
cord-001835-0s7ok4uw	1312	19	(	(	-LRB-
cord-001835-0s7ok4uw	1312	20	pivot	pivot	NN
cord-001835-0s7ok4uw	1312	21	)	)	-RRB-
cord-001835-0s7ok4uw	1312	22	,	,	,
cord-001835-0s7ok4uw	1312	23	and	and	CC
cord-001835-0s7ok4uw	1312	24	rotation	rotation	VB
cord-001835-0s7ok4uw	1312	25	around	around	RB
cord-001835-0s7ok4uw	1312	26	two	two	CD
cord-001835-0s7ok4uw	1312	27	points	point	NNS
cord-001835-0s7ok4uw	1312	28	(	(	-LRB-
cord-001835-0s7ok4uw	1312	29	hinge	hinge	NN
cord-001835-0s7ok4uw	1312	30	)	)	-RRB-
cord-001835-0s7ok4uw	1312	31	.	.	.
cord-001835-0s7ok4uw	1313	1	From	from	IN
cord-001835-0s7ok4uw	1313	2	these	these	DT
cord-001835-0s7ok4uw	1313	3	operations	operation	NNS
cord-001835-0s7ok4uw	1313	4	,	,	,
cord-001835-0s7ok4uw	1313	5	a	a	DT
cord-001835-0s7ok4uw	1313	6	directed	direct	VBN
cord-001835-0s7ok4uw	1313	7	acyclic	acyclic	JJ
cord-001835-0s7ok4uw	1313	8	graph	graph	NN
cord-001835-0s7ok4uw	1313	9	(	(	-LRB-
cord-001835-0s7ok4uw	1313	10	DAG	DAG	NNP
cord-001835-0s7ok4uw	1313	11	)	)	-RRB-
cord-001835-0s7ok4uw	1313	12	is	be	VBZ
cord-001835-0s7ok4uw	1313	13	constructed	construct	VBN
cord-001835-0s7ok4uw	1313	14	where	where	WRB
cord-001835-0s7ok4uw	1313	15	nodes	node	NNS
cord-001835-0s7ok4uw	1313	16	correspond	correspond	VBP
cord-001835-0s7ok4uw	1313	17	to	to	IN
cord-001835-0s7ok4uw	1313	18	the	the	DT
cord-001835-0s7ok4uw	1313	19	substructures	substructure	NNS
cord-001835-0s7ok4uw	1313	20	created	create	VBN
cord-001835-0s7ok4uw	1313	21	by	by	IN
cord-001835-0s7ok4uw	1313	22	these	these	DT
cord-001835-0s7ok4uw	1313	23	operations	operation	NNS
cord-001835-0s7ok4uw	1313	24	and	and	CC
cord-001835-0s7ok4uw	1313	25	the	the	DT
cord-001835-0s7ok4uw	1313	26	edges	edge	NNS
cord-001835-0s7ok4uw	1313	27	represent	represent	VBP
cord-001835-0s7ok4uw	1313	28	the	the	DT
cord-001835-0s7ok4uw	1313	29	operations	operation	NNS
cord-001835-0s7ok4uw	1313	30	.	.	.
cord-001835-0s7ok4uw	1314	1	For	for	IN
cord-001835-0s7ok4uw	1314	2	each	each	DT
cord-001835-0s7ok4uw	1314	3	operation	operation	NN
cord-001835-0s7ok4uw	1314	4	in	in	IN
cord-001835-0s7ok4uw	1314	5	the	the	DT
cord-001835-0s7ok4uw	1314	6	DAG	DAG	NNP
cord-001835-0s7ok4uw	1314	7	,	,	,
cord-001835-0s7ok4uw	1314	8	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1314	9	dissociation	dissociation	NN
cord-001835-0s7ok4uw	1314	10	and	and	CC
cord-001835-0s7ok4uw	1314	11	reassociation	reassociation	NN
cord-001835-0s7ok4uw	1314	12	rates	rate	NNS
cord-001835-0s7ok4uw	1314	13	are	be	VBP
cord-001835-0s7ok4uw	1314	14	determined	determine	VBN
cord-001835-0s7ok4uw	1314	15	as	as	IN
cord-001835-0s7ok4uw	1314	16	a	a	DT
cord-001835-0s7ok4uw	1314	17	function	function	NN
cord-001835-0s7ok4uw	1314	18	of	of	IN
cord-001835-0s7ok4uw	1314	19	solventaccessible	solventaccessible	JJ
cord-001835-0s7ok4uw	1314	20	surface	surface	NN
cord-001835-0s7ok4uw	1314	21	area	area	NN
cord-001835-0s7ok4uw	1314	22	,	,	,
cord-001835-0s7ok4uw	1314	23	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	1314	24	bonds	bond	NNS
cord-001835-0s7ok4uw	1314	25	,	,	,
cord-001835-0s7ok4uw	1314	26	voids	void	NNS
cord-001835-0s7ok4uw	1314	27	,	,	,
cord-001835-0s7ok4uw	1314	28	and	and	CC
cord-001835-0s7ok4uw	1314	29	conformational	conformational	JJ
cord-001835-0s7ok4uw	1314	30	entropy	entropy	NN
cord-001835-0s7ok4uw	1314	31	.	.	.
cord-001835-0s7ok4uw	1315	1	Finite	finite	JJ
cord-001835-0s7ok4uw	1315	2	element	element	NN
cord-001835-0s7ok4uw	1315	3	simulations	simulation	NNS
cord-001835-0s7ok4uw	1315	4	are	be	VBP
cord-001835-0s7ok4uw	1315	5	carried	carry	VBN
cord-001835-0s7ok4uw	1315	6	out	out	RP
cord-001835-0s7ok4uw	1315	7	to	to	TO
cord-001835-0s7ok4uw	1315	8	simulate	simulate	VB
cord-001835-0s7ok4uw	1315	9	the	the	DT
cord-001835-0s7ok4uw	1315	10	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	1315	11	of	of	IN
cord-001835-0s7ok4uw	1315	12	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1315	13	.	.	.
cord-001835-0s7ok4uw	1316	1	This	this	DT
cord-001835-0s7ok4uw	1316	2	model	model	NN
cord-001835-0s7ok4uw	1316	3	accurately	accurately	RB
cord-001835-0s7ok4uw	1316	4	predicts	predict	VBZ
cord-001835-0s7ok4uw	1316	5	changes	change	NNS
cord-001835-0s7ok4uw	1316	6	in	in	IN
cord-001835-0s7ok4uw	1316	7	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1316	8	pathways	pathway	NNS
cord-001835-0s7ok4uw	1316	9	due	due	JJ
cord-001835-0s7ok4uw	1316	10	to	to	IN
cord-001835-0s7ok4uw	1316	11	disulfides	disulfide	NNS
cord-001835-0s7ok4uw	1316	12	in	in	IN
cord-001835-0s7ok4uw	1316	13	a	a	DT
cord-001835-0s7ok4uw	1316	14	four	four	CD
cord-001835-0s7ok4uw	1316	15	-	-	HYPH
cord-001835-0s7ok4uw	1316	16	protein	protein	NN
cord-001835-0s7ok4uw	1316	17	case	case	NN
cord-001835-0s7ok4uw	1316	18	-	-	HYPH
cord-001835-0s7ok4uw	1316	19	study	study	NN
cord-001835-0s7ok4uw	1316	20	,	,	,
cord-001835-0s7ok4uw	1316	21	but	but	CC
cord-001835-0s7ok4uw	1316	22	it	-PRON-	PRP
cord-001835-0s7ok4uw	1316	23	fails	fail	VBZ
cord-001835-0s7ok4uw	1316	24	to	to	TO
cord-001835-0s7ok4uw	1316	25	produce	produce	VB
cord-001835-0s7ok4uw	1316	26	a	a	DT
cord-001835-0s7ok4uw	1316	27	realistic	realistic	JJ
cord-001835-0s7ok4uw	1316	28	pathway	pathway	NN
cord-001835-0s7ok4uw	1316	29	for	for	IN
cord-001835-0s7ok4uw	1316	30	b	b	NN
cord-001835-0s7ok4uw	1316	31	-	-	HYPH
cord-001835-0s7ok4uw	1316	32	barrel	barrel	NN
cord-001835-0s7ok4uw	1316	33	proteins	protein	NNS
cord-001835-0s7ok4uw	1316	34	such	such	JJ
cord-001835-0s7ok4uw	1316	35	as	as	IN
cord-001835-0s7ok4uw	1316	36	green	green	JJ
cord-001835-0s7ok4uw	1316	37	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	1316	38	protein	protein	NN
cord-001835-0s7ok4uw	1316	39	(	(	-LRB-
cord-001835-0s7ok4uw	1316	40	GFP	GFP	NNP
cord-001835-0s7ok4uw	1316	41	)	)	-RRB-
cord-001835-0s7ok4uw	1316	42	.	.	.
cord-001835-0s7ok4uw	1317	1	To	to	TO
cord-001835-0s7ok4uw	1317	2	better	well	RBR
cord-001835-0s7ok4uw	1317	3	model	model	VB
cord-001835-0s7ok4uw	1317	4	these	these	DT
cord-001835-0s7ok4uw	1317	5	barrel	barrel	NN
cord-001835-0s7ok4uw	1317	6	proteins	protein	NNS
cord-001835-0s7ok4uw	1317	7	,	,	,
cord-001835-0s7ok4uw	1317	8	a	a	DT
cord-001835-0s7ok4uw	1317	9	new	new	JJ
cord-001835-0s7ok4uw	1317	10	partitioning	partitioning	NN
cord-001835-0s7ok4uw	1317	11	operation	operation	NN
cord-001835-0s7ok4uw	1317	12	is	be	VBZ
cord-001835-0s7ok4uw	1317	13	introduced	introduce	VBN
cord-001835-0s7ok4uw	1317	14	involving	involve	VBG
cord-001835-0s7ok4uw	1317	15	the	the	DT
cord-001835-0s7ok4uw	1317	16	breaking	breaking	NN
cord-001835-0s7ok4uw	1317	17	of	of	IN
cord-001835-0s7ok4uw	1317	18	all	all	DT
cord-001835-0s7ok4uw	1317	19	contacts	contact	NNS
cord-001835-0s7ok4uw	1317	20	between	between	IN
cord-001835-0s7ok4uw	1317	21	an	an	DT
cord-001835-0s7ok4uw	1317	22	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	1317	23	set	set	NN
cord-001835-0s7ok4uw	1317	24	of	of	IN
cord-001835-0s7ok4uw	1317	25	b	b	NN
cord-001835-0s7ok4uw	1317	26	-	-	HYPH
cord-001835-0s7ok4uw	1317	27	strands	strand	NNS
cord-001835-0s7ok4uw	1317	28	,	,	,
cord-001835-0s7ok4uw	1317	29	called	call	VBD
cord-001835-0s7ok4uw	1317	30	a	a	DT
cord-001835-0s7ok4uw	1317	31	seam	seam	NN
cord-001835-0s7ok4uw	1317	32	.	.	.
cord-001835-0s7ok4uw	1318	1	In	in	IN
cord-001835-0s7ok4uw	1318	2	addition	addition	NN
cord-001835-0s7ok4uw	1318	3	,	,	,
cord-001835-0s7ok4uw	1318	4	to	to	TO
cord-001835-0s7ok4uw	1318	5	improve	improve	VB
cord-001835-0s7ok4uw	1318	6	the	the	DT
cord-001835-0s7ok4uw	1318	7	accuracy	accuracy	NN
cord-001835-0s7ok4uw	1318	8	of	of	IN
cord-001835-0s7ok4uw	1318	9	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1318	10	modeling	modeling	NN
cord-001835-0s7ok4uw	1318	11	,	,	,
cord-001835-0s7ok4uw	1318	12	several	several	JJ
cord-001835-0s7ok4uw	1318	13	updates	update	NNS
cord-001835-0s7ok4uw	1318	14	have	have	VBP
cord-001835-0s7ok4uw	1318	15	been	be	VBN
cord-001835-0s7ok4uw	1318	16	made	make	VBN
cord-001835-0s7ok4uw	1318	17	to	to	IN
cord-001835-0s7ok4uw	1318	18	the	the	DT
cord-001835-0s7ok4uw	1318	19	energy	energy	NN
cord-001835-0s7ok4uw	1318	20	function	function	NN
cord-001835-0s7ok4uw	1318	21	,	,	,
cord-001835-0s7ok4uw	1318	22	including	include	VBG
cord-001835-0s7ok4uw	1318	23	an	an	DT
cord-001835-0s7ok4uw	1318	24	improved	improve	VBN
cord-001835-0s7ok4uw	1318	25	solvation	solvation	NN
cord-001835-0s7ok4uw	1318	26	model	model	NN
cord-001835-0s7ok4uw	1318	27	and	and	CC
cord-001835-0s7ok4uw	1318	28	a	a	DT
cord-001835-0s7ok4uw	1318	29	contact	contact	NN
cord-001835-0s7ok4uw	1318	30	-	-	HYPH
cord-001835-0s7ok4uw	1318	31	orderbased	orderbase	VBN
cord-001835-0s7ok4uw	1318	32	estimation	estimation	NN
cord-001835-0s7ok4uw	1318	33	of	of	IN
cord-001835-0s7ok4uw	1318	34	the	the	DT
cord-001835-0s7ok4uw	1318	35	reassociation	reassociation	NN
cord-001835-0s7ok4uw	1318	36	rates	rate	NNS
cord-001835-0s7ok4uw	1318	37	.	.	.
cord-001835-0s7ok4uw	1319	1	The	the	DT
cord-001835-0s7ok4uw	1319	2	predicted	predict	VBN
cord-001835-0s7ok4uw	1319	3	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1319	4	rates	rate	NNS
cord-001835-0s7ok4uw	1319	5	and	and	CC
cord-001835-0s7ok4uw	1319	6	pathways	pathway	NNS
cord-001835-0s7ok4uw	1319	7	using	use	VBG
cord-001835-0s7ok4uw	1319	8	this	this	DT
cord-001835-0s7ok4uw	1319	9	improved	improve	VBN
cord-001835-0s7ok4uw	1319	10	GeoFold	GeoFold	NNP
cord-001835-0s7ok4uw	1319	11	are	be	VBP
cord-001835-0s7ok4uw	1319	12	compared	compare	VBN
cord-001835-0s7ok4uw	1319	13	with	with	IN
cord-001835-0s7ok4uw	1319	14	experimentally	experimentally	RB
cord-001835-0s7ok4uw	1319	15	measured	measure	VBN
cord-001835-0s7ok4uw	1319	16	values	value	NNS
cord-001835-0s7ok4uw	1319	17	in	in	IN
cord-001835-0s7ok4uw	1319	18	KineticDB	KineticDB	NNS
cord-001835-0s7ok4uw	1319	19	for	for	IN
cord-001835-0s7ok4uw	1319	20	proteins	protein	NNS
cord-001835-0s7ok4uw	1319	21	with	with	IN
cord-001835-0s7ok4uw	1319	22	multi	multi	JJ
cord-001835-0s7ok4uw	1319	23	-	-	JJ
cord-001835-0s7ok4uw	1319	24	state	state	JJ
cord-001835-0s7ok4uw	1319	25	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1319	26	kinetics	kinetics	NN
cord-001835-0s7ok4uw	1319	27	,	,	,
cord-001835-0s7ok4uw	1319	28	point	point	NN
cord-001835-0s7ok4uw	1319	29	mutations	mutation	NNS
cord-001835-0s7ok4uw	1319	30	,	,	,
cord-001835-0s7ok4uw	1319	31	circular	circular	JJ
cord-001835-0s7ok4uw	1319	32	permutations	permutation	NNS
cord-001835-0s7ok4uw	1319	33	,	,	,
cord-001835-0s7ok4uw	1319	34	and	and	CC
cord-001835-0s7ok4uw	1319	35	engineered	engineer	VBN
cord-001835-0s7ok4uw	1319	36	disulfides	disulfide	NNS
cord-001835-0s7ok4uw	1319	37	.	.	.
cord-001835-0s7ok4uw	1320	1	The	the	DT
cord-001835-0s7ok4uw	1320	2	presence	presence	NN
cord-001835-0s7ok4uw	1320	3	of	of	IN
cord-001835-0s7ok4uw	1320	4	multiple	multiple	JJ
cord-001835-0s7ok4uw	1320	5	domains	domain	NNS
cord-001835-0s7ok4uw	1320	6	in	in	IN
cord-001835-0s7ok4uw	1320	7	a	a	DT
cord-001835-0s7ok4uw	1320	8	protein	protein	NN
cord-001835-0s7ok4uw	1320	9	can	can	MD
cord-001835-0s7ok4uw	1320	10	result	result	VB
cord-001835-0s7ok4uw	1320	11	in	in	IN
cord-001835-0s7ok4uw	1320	12	the	the	DT
cord-001835-0s7ok4uw	1320	13	formation	formation	NN
cord-001835-0s7ok4uw	1320	14	of	of	IN
cord-001835-0s7ok4uw	1320	15	partially	partially	RB
cord-001835-0s7ok4uw	1320	16	folded	fold	VBN
cord-001835-0s7ok4uw	1320	17	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	1320	18	,	,	,
cord-001835-0s7ok4uw	1320	19	leading	lead	VBG
cord-001835-0s7ok4uw	1320	20	to	to	IN
cord-001835-0s7ok4uw	1320	21	increased	increase	VBN
cord-001835-0s7ok4uw	1320	22	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1320	23	propensity	propensity	NN
cord-001835-0s7ok4uw	1320	24	.	.	.
cord-001835-0s7ok4uw	1321	1	This	this	DT
cord-001835-0s7ok4uw	1321	2	can	can	MD
cord-001835-0s7ok4uw	1321	3	be	be	VB
cord-001835-0s7ok4uw	1321	4	reduced	reduce	VBN
cord-001835-0s7ok4uw	1321	5	by	by	IN
cord-001835-0s7ok4uw	1321	6	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	1321	7	,	,	,
cord-001835-0s7ok4uw	1321	8	all	all	DT
cord-001835-0s7ok4uw	1321	9	-	-	HYPH
cord-001835-0s7ok4uw	1321	10	or	or	CC
cord-001835-0s7ok4uw	1321	11	-	-	HYPH
cord-001835-0s7ok4uw	1321	12	nothing	nothing	NN
cord-001835-0s7ok4uw	1321	13	folding	folding	NN
cord-001835-0s7ok4uw	1321	14	of	of	IN
cord-001835-0s7ok4uw	1321	15	the	the	DT
cord-001835-0s7ok4uw	1321	16	multi	multi	JJ
cord-001835-0s7ok4uw	1321	17	-	-	JJ
cord-001835-0s7ok4uw	1321	18	domain	domain	JJ
cord-001835-0s7ok4uw	1321	19	protein	protein	NN
cord-001835-0s7ok4uw	1321	20	.	.	.
cord-001835-0s7ok4uw	1322	1	In	in	IN
cord-001835-0s7ok4uw	1322	2	good	good	JJ
cord-001835-0s7ok4uw	1322	3	agreement	agreement	NN
cord-001835-0s7ok4uw	1322	4	with	with	IN
cord-001835-0s7ok4uw	1322	5	ensemble	ensemble	JJ
cord-001835-0s7ok4uw	1322	6	folding	fold	VBG
cord-001835-0s7ok4uw	1322	7	experiments	experiment	NNS
cord-001835-0s7ok4uw	1322	8	,	,	,
cord-001835-0s7ok4uw	1322	9	a	a	DT
cord-001835-0s7ok4uw	1322	10	coarsegrained	coarsegraine	VBN
cord-001835-0s7ok4uw	1322	11	structure	structure	NN
cord-001835-0s7ok4uw	1322	12	-	-	HYPH
cord-001835-0s7ok4uw	1322	13	based	base	VBN
cord-001835-0s7ok4uw	1322	14	model	model	NN
cord-001835-0s7ok4uw	1322	15	of	of	IN
cord-001835-0s7ok4uw	1322	16	E.	E.	NNP
cord-001835-0s7ok4uw	1322	17	coli	coli	NNS
cord-001835-0s7ok4uw	1322	18	Adenylate	Adenylate	NNP
cord-001835-0s7ok4uw	1322	19	kinase	kinase	NN
cord-001835-0s7ok4uw	1322	20	(	(	-LRB-
cord-001835-0s7ok4uw	1322	21	AKE	AKE	NNP
cord-001835-0s7ok4uw	1322	22	)	)	-RRB-
cord-001835-0s7ok4uw	1322	23	folds	fold	VBZ
cord-001835-0s7ok4uw	1322	24	cooperatively	cooperatively	RB
cord-001835-0s7ok4uw	1322	25	.	.	.
cord-001835-0s7ok4uw	1323	1	AKE	AKE	NNP
cord-001835-0s7ok4uw	1323	2	has	have	VBZ
cord-001835-0s7ok4uw	1323	3	three	three	CD
cord-001835-0s7ok4uw	1323	4	domains	domain	NNS
cord-001835-0s7ok4uw	1323	5	,	,	,
cord-001835-0s7ok4uw	1323	6	NMP	NMP	NNP
cord-001835-0s7ok4uw	1323	7	,	,	,
cord-001835-0s7ok4uw	1323	8	LID	lid	NN
cord-001835-0s7ok4uw	1323	9	and	and	CC
cord-001835-0s7ok4uw	1323	10	CORE	core	NN
cord-001835-0s7ok4uw	1323	11	.	.	.
cord-001835-0s7ok4uw	1324	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1324	2	examine	examine	VBP
cord-001835-0s7ok4uw	1324	3	the	the	DT
cord-001835-0s7ok4uw	1324	4	role	role	NN
cord-001835-0s7ok4uw	1324	5	of	of	IN
cord-001835-0s7ok4uw	1324	6	the	the	DT
cord-001835-0s7ok4uw	1324	7	interfaces	interface	NNS
cord-001835-0s7ok4uw	1324	8	between	between	IN
cord-001835-0s7ok4uw	1324	9	these	these	DT
cord-001835-0s7ok4uw	1324	10	domains	domain	NNS
cord-001835-0s7ok4uw	1324	11	in	in	IN
cord-001835-0s7ok4uw	1324	12	facilitating	facilitate	VBG
cord-001835-0s7ok4uw	1324	13	folding	fold	VBG
cord-001835-0s7ok4uw	1324	14	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	1324	15	in	in	IN
cord-001835-0s7ok4uw	1324	16	AKE	AKE	NNP
cord-001835-0s7ok4uw	1324	17	.	.	.
cord-001835-0s7ok4uw	1325	1	Mutants	mutant	NNS
cord-001835-0s7ok4uw	1325	2	in	in	IN
cord-001835-0s7ok4uw	1325	3	which	which	WDT
cord-001835-0s7ok4uw	1325	4	these	these	DT
cord-001835-0s7ok4uw	1325	5	interfaces	interface	NNS
cord-001835-0s7ok4uw	1325	6	are	be	VBP
cord-001835-0s7ok4uw	1325	7	deleted	delete	VBN
cord-001835-0s7ok4uw	1325	8	exhibit	exhibit	NN
cord-001835-0s7ok4uw	1325	9	similar	similar	JJ
cord-001835-0s7ok4uw	1325	10	folding	folding	NN
cord-001835-0s7ok4uw	1325	11	cooperativities	cooperativitie	NNS
cord-001835-0s7ok4uw	1325	12	as	as	IN
cord-001835-0s7ok4uw	1325	13	wild	wild	JJ
cord-001835-0s7ok4uw	1325	14	-	-	HYPH
cord-001835-0s7ok4uw	1325	15	type	type	NN
cord-001835-0s7ok4uw	1325	16	AKE	AKE	NNP
cord-001835-0s7ok4uw	1325	17	.	.	.
cord-001835-0s7ok4uw	1326	1	On	on	IN
cord-001835-0s7ok4uw	1326	2	closer	close	JJR
cord-001835-0s7ok4uw	1326	3	inspection	inspection	NN
cord-001835-0s7ok4uw	1326	4	,	,	,
cord-001835-0s7ok4uw	1326	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1326	6	observe	observe	VBP
cord-001835-0s7ok4uw	1326	7	that	that	IN
cord-001835-0s7ok4uw	1326	8	unlike	unlike	IN
cord-001835-0s7ok4uw	1326	9	a	a	DT
cord-001835-0s7ok4uw	1326	10	typical	typical	JJ
cord-001835-0s7ok4uw	1326	11	multi	multi	JJ
cord-001835-0s7ok4uw	1326	12	-	-	JJ
cord-001835-0s7ok4uw	1326	13	domain	domain	JJ
cord-001835-0s7ok4uw	1326	14	protein	protein	NN
cord-001835-0s7ok4uw	1326	15	in	in	IN
cord-001835-0s7ok4uw	1326	16	which	which	WDT
cord-001835-0s7ok4uw	1326	17	one	one	CD
cord-001835-0s7ok4uw	1326	18	domain	domain	NN
cord-001835-0s7ok4uw	1326	19	is	be	VBZ
cord-001835-0s7ok4uw	1326	20	singly	singly	RB
cord-001835-0s7ok4uw	1326	21	-	-	HYPH
cord-001835-0s7ok4uw	1326	22	linked	link	VBN
cord-001835-0s7ok4uw	1326	23	to	to	IN
cord-001835-0s7ok4uw	1326	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1326	25	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	1326	26	domain	domain	NN
cord-001835-0s7ok4uw	1326	27	,	,	,
cord-001835-0s7ok4uw	1326	28	NMP	NMP	NNP
cord-001835-0s7ok4uw	1326	29	and	and	CC
cord-001835-0s7ok4uw	1326	30	LID	LID	NNP
cord-001835-0s7ok4uw	1326	31	are	be	VBP
cord-001835-0s7ok4uw	1326	32	inserted	insert	VBN
cord-001835-0s7ok4uw	1326	33	into	into	IN
cord-001835-0s7ok4uw	1326	34	CORE	core	NN
cord-001835-0s7ok4uw	1326	35	,	,	,
cord-001835-0s7ok4uw	1327	1	i.e.	i.e.	FW
cord-001835-0s7ok4uw	1327	2	they	-PRON-	PRP
cord-001835-0s7ok4uw	1327	3	are	be	VBP
cord-001835-0s7ok4uw	1327	4	both	both	RB
cord-001835-0s7ok4uw	1327	5	connected	connect	VBN
cord-001835-0s7ok4uw	1327	6	to	to	IN
cord-001835-0s7ok4uw	1327	7	CORE	core	NN
cord-001835-0s7ok4uw	1327	8	by	by	IN
cord-001835-0s7ok4uw	1327	9	two	two	CD
cord-001835-0s7ok4uw	1327	10	linkers	linker	NNS
cord-001835-0s7ok4uw	1327	11	each	each	DT
cord-001835-0s7ok4uw	1327	12	.	.	.
cord-001835-0s7ok4uw	1328	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1328	2	create	create	VBP
cord-001835-0s7ok4uw	1328	3	circular	circular	JJ
cord-001835-0s7ok4uw	1328	4	permutants	permutant	NNS
cord-001835-0s7ok4uw	1328	5	of	of	IN
cord-001835-0s7ok4uw	1328	6	AKE	AKE	NNP
cord-001835-0s7ok4uw	1328	7	in	in	IN
cord-001835-0s7ok4uw	1328	8	which	which	WDT
cord-001835-0s7ok4uw	1328	9	the	the	DT
cord-001835-0s7ok4uw	1328	10	inserted	insert	VBN
cord-001835-0s7ok4uw	1328	11	domains	domain	NNS
cord-001835-0s7ok4uw	1328	12	are	be	VBP
cord-001835-0s7ok4uw	1328	13	converted	convert	VBN
cord-001835-0s7ok4uw	1328	14	to	to	IN
cord-001835-0s7ok4uw	1328	15	singly	singly	RB
cord-001835-0s7ok4uw	1328	16	-	-	HYPH
cord-001835-0s7ok4uw	1328	17	linked	link	VBN
cord-001835-0s7ok4uw	1328	18	domains	domain	NNS
cord-001835-0s7ok4uw	1328	19	,	,	,
cord-001835-0s7ok4uw	1328	20	and	and	CC
cord-001835-0s7ok4uw	1328	21	find	find	VB
cord-001835-0s7ok4uw	1328	22	that	that	IN
cord-001835-0s7ok4uw	1328	23	they	-PRON-	PRP
cord-001835-0s7ok4uw	1328	24	fold	fold	VBP
cord-001835-0s7ok4uw	1328	25	less	less	RBR
cord-001835-0s7ok4uw	1328	26	cooperatively	cooperatively	RB
cord-001835-0s7ok4uw	1328	27	than	than	IN
cord-001835-0s7ok4uw	1328	28	wild	wild	JJ
cord-001835-0s7ok4uw	1328	29	-	-	HYPH
cord-001835-0s7ok4uw	1328	30	type	type	NN
cord-001835-0s7ok4uw	1328	31	AKE	AKE	NNP
cord-001835-0s7ok4uw	1328	32	.	.	.
cord-001835-0s7ok4uw	1329	1	Domain	domain	NN
cord-001835-0s7ok4uw	1329	2	insertion	insertion	NN
cord-001835-0s7ok4uw	1329	3	in	in	IN
cord-001835-0s7ok4uw	1329	4	wild	wild	JJ
cord-001835-0s7ok4uw	1329	5	-	-	HYPH
cord-001835-0s7ok4uw	1329	6	type	type	NN
cord-001835-0s7ok4uw	1329	7	AKE	AKE	NNP
cord-001835-0s7ok4uw	1329	8	facilitates	facilitate	VBZ
cord-001835-0s7ok4uw	1329	9	folding	fold	VBG
cord-001835-0s7ok4uw	1329	10	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	1329	11	even	even	RB
cord-001835-0s7ok4uw	1329	12	when	when	WRB
cord-001835-0s7ok4uw	1329	13	the	the	DT
cord-001835-0s7ok4uw	1329	14	inserted	insert	VBN
cord-001835-0s7ok4uw	1329	15	domains	domain	NNS
cord-001835-0s7ok4uw	1329	16	have	have	VBP
cord-001835-0s7ok4uw	1329	17	lower	low	JJR
cord-001835-0s7ok4uw	1329	18	stabilities	stability	NNS
cord-001835-0s7ok4uw	1329	19	.	.	.
cord-001835-0s7ok4uw	1330	1	The	the	DT
cord-001835-0s7ok4uw	1330	2	N	N	NNP
cord-001835-0s7ok4uw	1330	3	-	-	HYPH
cord-001835-0s7ok4uw	1330	4	and	and	CC
cord-001835-0s7ok4uw	1330	5	C	C	NNP
cord-001835-0s7ok4uw	1330	6	-	-	HYPH
cord-001835-0s7ok4uw	1330	7	termini	termini	NNP
cord-001835-0s7ok4uw	1330	8	of	of	IN
cord-001835-0s7ok4uw	1330	9	NMP	NMP	NNP
cord-001835-0s7ok4uw	1330	10	and	and	CC
cord-001835-0s7ok4uw	1330	11	LID	lid	NN
cord-001835-0s7ok4uw	1330	12	are	be	VBP
cord-001835-0s7ok4uw	1330	13	constrained	constrain	VBN
cord-001835-0s7ok4uw	1330	14	upon	upon	IN
cord-001835-0s7ok4uw	1330	15	the	the	DT
cord-001835-0s7ok4uw	1330	16	folding	folding	NN
cord-001835-0s7ok4uw	1330	17	of	of	IN
cord-001835-0s7ok4uw	1330	18	CORE	core	NN
cord-001835-0s7ok4uw	1330	19	and	and	CC
cord-001835-0s7ok4uw	1330	20	this	this	DT
cord-001835-0s7ok4uw	1330	21	facilitates	facilitate	VBZ
cord-001835-0s7ok4uw	1330	22	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1330	23	folding	folding	NN
cord-001835-0s7ok4uw	1330	24	.	.	.
cord-001835-0s7ok4uw	1331	1	Thus	thus	RB
cord-001835-0s7ok4uw	1331	2	,	,	,
cord-001835-0s7ok4uw	1331	3	NMP	NMP	NNP
cord-001835-0s7ok4uw	1331	4	and	and	CC
cord-001835-0s7ok4uw	1331	5	LID	lid	NN
cord-001835-0s7ok4uw	1331	6	which	which	WDT
cord-001835-0s7ok4uw	1331	7	undergo	undergo	VBP
cord-001835-0s7ok4uw	1331	8	large	large	JJ
cord-001835-0s7ok4uw	1331	9	conformational	conformational	JJ
cord-001835-0s7ok4uw	1331	10	changes	change	NNS
cord-001835-0s7ok4uw	1331	11	during	during	IN
cord-001835-0s7ok4uw	1331	12	catalysis	catalysis	NN
cord-001835-0s7ok4uw	1331	13	can	can	MD
cord-001835-0s7ok4uw	1331	14	be	be	VB
cord-001835-0s7ok4uw	1331	15	smaller	small	JJR
cord-001835-0s7ok4uw	1331	16	with	with	IN
cord-001835-0s7ok4uw	1331	17	fewer	few	JJR
cord-001835-0s7ok4uw	1331	18	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	1331	19	interactions	interaction	NNS
cord-001835-0s7ok4uw	1331	20	.	.	.
cord-001835-0s7ok4uw	1332	1	In	in	IN
cord-001835-0s7ok4uw	1332	2	addition	addition	NN
cord-001835-0s7ok4uw	1332	3	,	,	,
cord-001835-0s7ok4uw	1332	4	inter	inter	JJ
cord-001835-0s7ok4uw	1332	5	-	-	NN
cord-001835-0s7ok4uw	1332	6	domain	domain	NN
cord-001835-0s7ok4uw	1332	7	interactions	interaction	NNS
cord-001835-0s7ok4uw	1332	8	need	nee	MD
cord-001835-0s7ok4uw	1332	9	not	not	RB
cord-001835-0s7ok4uw	1332	10	be	be	VB
cord-001835-0s7ok4uw	1332	11	optimized	optimize	VBN
cord-001835-0s7ok4uw	1332	12	for	for	IN
cord-001835-0s7ok4uw	1332	13	folding	folding	NN
cord-001835-0s7ok4uw	1332	14	,	,	,
cord-001835-0s7ok4uw	1332	15	and	and	CC
cord-001835-0s7ok4uw	1332	16	can	can	MD
cord-001835-0s7ok4uw	1332	17	be	be	VB
cord-001835-0s7ok4uw	1332	18	tuned	tune	VBN
cord-001835-0s7ok4uw	1332	19	for	for	IN
cord-001835-0s7ok4uw	1332	20	substrate	substrate	NN
cord-001835-0s7ok4uw	1332	21	binding	bind	VBG
cord-001835-0s7ok4uw	1332	22	,	,	,
cord-001835-0s7ok4uw	1332	23	conformational	conformational	JJ
cord-001835-0s7ok4uw	1332	24	transition	transition	NN
cord-001835-0s7ok4uw	1332	25	and	and	CC
cord-001835-0s7ok4uw	1332	26	catalysis	catalysis	NN
cord-001835-0s7ok4uw	1332	27	.	.	.
cord-001835-0s7ok4uw	1333	1	Analysis	analysis	NN
cord-001835-0s7ok4uw	1333	2	of	of	IN
cord-001835-0s7ok4uw	1333	3	protein	protein	NN
cord-001835-0s7ok4uw	1333	4	domains	domain	NNS
cord-001835-0s7ok4uw	1333	5	using	use	VBG
cord-001835-0s7ok4uw	1333	6	structural	structural	JJ
cord-001835-0s7ok4uw	1333	7	bioinformatics	bioinformatics	NN
cord-001835-0s7ok4uw	1333	8	suggests	suggest	VBZ
cord-001835-0s7ok4uw	1333	9	several	several	JJ
cord-001835-0s7ok4uw	1333	10	examples	example	NNS
cord-001835-0s7ok4uw	1333	11	of	of	IN
cord-001835-0s7ok4uw	1333	12	multi	multi	JJ
cord-001835-0s7ok4uw	1333	13	-	-	JJ
cord-001835-0s7ok4uw	1333	14	domain	domain	NN
cord-001835-0s7ok4uw	1333	15	proteins	protein	NNS
cord-001835-0s7ok4uw	1333	16	in	in	IN
cord-001835-0s7ok4uw	1333	17	which	which	WDT
cord-001835-0s7ok4uw	1333	18	domain	domain	NN
cord-001835-0s7ok4uw	1333	19	insertion	insertion	NN
cord-001835-0s7ok4uw	1333	20	is	be	VBZ
cord-001835-0s7ok4uw	1333	21	likely	likely	JJ
cord-001835-0s7ok4uw	1333	22	to	to	TO
cord-001835-0s7ok4uw	1333	23	facilitate	facilitate	VB
cord-001835-0s7ok4uw	1333	24	folding	fold	VBG
cord-001835-0s7ok4uw	1333	25	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	1333	26	.	.	.
cord-001835-0s7ok4uw	1334	1	Tuning	tune	VBG
cord-001835-0s7ok4uw	1334	2	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	1334	3	on	on	IN
cord-001835-0s7ok4uw	1334	4	the	the	DT
cord-001835-0s7ok4uw	1334	5	free	free	JJ
cord-001835-0s7ok4uw	1334	6	energy	energy	NN
cord-001835-0s7ok4uw	1334	7	landscape	landscape	NN
cord-001835-0s7ok4uw	1334	8	of	of	IN
cord-001835-0s7ok4uw	1334	9	protein	protein	NN
cord-001835-0s7ok4uw	1334	10	folding	fold	VBG
cord-001835-0s7ok4uw	1334	11	Pooja	Pooja	NNP
cord-001835-0s7ok4uw	1334	12	Malhotra	Malhotra	NNP
cord-001835-0s7ok4uw	1334	13	1	1	CD
cord-001835-0s7ok4uw	1334	14	,	,	,
cord-001835-0s7ok4uw	1334	15	Jayant	Jayant	NNP
cord-001835-0s7ok4uw	1334	16	Udgaonkar	Udgaonkar	NNP
cord-001835-0s7ok4uw	1334	17	1	1	CD
cord-001835-0s7ok4uw	1334	18	1	1	CD
cord-001835-0s7ok4uw	1334	19	National	National	NNP
cord-001835-0s7ok4uw	1334	20	Centre	Centre	NNP
cord-001835-0s7ok4uw	1334	21	for	for	IN
cord-001835-0s7ok4uw	1334	22	Biological	Biological	NNP
cord-001835-0s7ok4uw	1334	23	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	1334	24	,	,	,
cord-001835-0s7ok4uw	1334	25	Tata	Tata	NNP
cord-001835-0s7ok4uw	1334	26	Institute	Institute	NNP
cord-001835-0s7ok4uw	1334	27	of	of	IN
cord-001835-0s7ok4uw	1334	28	Fundamental	Fundamental	NNP
cord-001835-0s7ok4uw	1334	29	Research	Research	NNP
cord-001835-0s7ok4uw	1335	1	The	the	DT
cord-001835-0s7ok4uw	1335	2	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1335	3	by	by	IN
cord-001835-0s7ok4uw	1335	4	which	which	WDT
cord-001835-0s7ok4uw	1335	5	a	a	DT
cord-001835-0s7ok4uw	1335	6	protein	protein	NN
cord-001835-0s7ok4uw	1335	7	explores	explore	VBZ
cord-001835-0s7ok4uw	1335	8	the	the	DT
cord-001835-0s7ok4uw	1335	9	free	free	JJ
cord-001835-0s7ok4uw	1335	10	energy	energy	NN
cord-001835-0s7ok4uw	1335	11	landscape	landscape	NN
cord-001835-0s7ok4uw	1335	12	during	during	IN
cord-001835-0s7ok4uw	1335	13	a	a	DT
cord-001835-0s7ok4uw	1335	14	folding	folding	NN
cord-001835-0s7ok4uw	1335	15	or	or	CC
cord-001835-0s7ok4uw	1335	16	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1335	17	reaction	reaction	NN
cord-001835-0s7ok4uw	1335	18	is	be	VBZ
cord-001835-0s7ok4uw	1335	19	poorly	poorly	RB
cord-001835-0s7ok4uw	1335	20	understood	understand	VBN
cord-001835-0s7ok4uw	1335	21	.	.	.
cord-001835-0s7ok4uw	1336	1	Determining	determine	VBG
cord-001835-0s7ok4uw	1336	2	whether	whether	IN
cord-001835-0s7ok4uw	1336	3	these	these	DT
cord-001835-0s7ok4uw	1336	4	reactions	reaction	NNS
cord-001835-0s7ok4uw	1336	5	are	be	VBP
cord-001835-0s7ok4uw	1336	6	slowed	slow	VBN
cord-001835-0s7ok4uw	1336	7	down	down	RP
cord-001835-0s7ok4uw	1336	8	by	by	IN
cord-001835-0s7ok4uw	1336	9	a	a	DT
cord-001835-0s7ok4uw	1336	10	continuum	continuum	NN
cord-001835-0s7ok4uw	1336	11	of	of	IN
cord-001835-0s7ok4uw	1336	12	small	small	JJ
cord-001835-0s7ok4uw	1336	13	(	(	-LRB-
cord-001835-0s7ok4uw	1336	14	kBT	kbt	VB
cord-001835-0s7ok4uw	1336	15	)	)	-RRB-
cord-001835-0s7ok4uw	1336	16	free	free	JJ
cord-001835-0s7ok4uw	1336	17	energy	energy	NN
cord-001835-0s7ok4uw	1336	18	barriers	barrier	NNS
cord-001835-0s7ok4uw	1336	19	or	or	CC
cord-001835-0s7ok4uw	1336	20	by	by	IN
cord-001835-0s7ok4uw	1336	21	a	a	DT
cord-001835-0s7ok4uw	1336	22	few	few	JJ
cord-001835-0s7ok4uw	1336	23	large	large	JJ
cord-001835-0s7ok4uw	1336	24	(	(	-LRB-
cord-001835-0s7ok4uw	1336	25	>	>	NN
cord-001835-0s7ok4uw	1336	26	3	3	CD
cord-001835-0s7ok4uw	1336	27	kBT	kbt	VB
cord-001835-0s7ok4uw	1336	28	)	)	-RRB-
cord-001835-0s7ok4uw	1336	29	free	free	JJ
cord-001835-0s7ok4uw	1336	30	energy	energy	NN
cord-001835-0s7ok4uw	1336	31	barriers	barrier	NNS
cord-001835-0s7ok4uw	1336	32	is	be	VBZ
cord-001835-0s7ok4uw	1336	33	a	a	DT
cord-001835-0s7ok4uw	1336	34	major	major	JJ
cord-001835-0s7ok4uw	1336	35	challenge	challenge	NN
cord-001835-0s7ok4uw	1336	36	.	.	.
cord-001835-0s7ok4uw	1337	1	In	in	IN
cord-001835-0s7ok4uw	1337	2	this	this	DT
cord-001835-0s7ok4uw	1337	3	study	study	NN
cord-001835-0s7ok4uw	1337	4	the	the	DT
cord-001835-0s7ok4uw	1337	5	free	free	JJ
cord-001835-0s7ok4uw	1337	6	energy	energy	NN
cord-001835-0s7ok4uw	1337	7	landscape	landscape	NN
cord-001835-0s7ok4uw	1337	8	accessible	accessible	JJ
cord-001835-0s7ok4uw	1337	9	to	to	IN
cord-001835-0s7ok4uw	1337	10	a	a	DT
cord-001835-0s7ok4uw	1337	11	small	small	JJ
cord-001835-0s7ok4uw	1337	12	protein	protein	NN
cord-001835-0s7ok4uw	1337	13	monellin	monellin	NNP
cord-001835-0s7ok4uw	1337	14	is	be	VBZ
cord-001835-0s7ok4uw	1337	15	characterized	characterize	VBN
cord-001835-0s7ok4uw	1337	16	under	under	IN
cord-001835-0s7ok4uw	1337	17	native	native	JJ
cord-001835-0s7ok4uw	1337	18	-	-	HYPH
cord-001835-0s7ok4uw	1337	19	like	like	JJ
cord-001835-0s7ok4uw	1337	20	conditions	condition	NNS
cord-001835-0s7ok4uw	1337	21	using	use	VBG
cord-001835-0s7ok4uw	1337	22	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	1337	23	exchange	exchange	NN
cord-001835-0s7ok4uw	1337	24	in	in	IN
cord-001835-0s7ok4uw	1337	25	conjunction	conjunction	NN
cord-001835-0s7ok4uw	1337	26	with	with	IN
cord-001835-0s7ok4uw	1337	27	mass	mass	NN
cord-001835-0s7ok4uw	1337	28	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	1337	29	.	.	.
cord-001835-0s7ok4uw	1338	1	Cooperative	cooperative	JJ
cord-001835-0s7ok4uw	1338	2	and	and	CC
cord-001835-0s7ok4uw	1338	3	noncooperative	noncooperative	JJ
cord-001835-0s7ok4uw	1338	4	opening	opening	NN
cord-001835-0s7ok4uw	1338	5	processes	process	NNS
cord-001835-0s7ok4uw	1338	6	could	could	MD
cord-001835-0s7ok4uw	1338	7	be	be	VB
cord-001835-0s7ok4uw	1338	8	directly	directly	RB
cord-001835-0s7ok4uw	1338	9	distinguished	distinguish	VBN
cord-001835-0s7ok4uw	1338	10	from	from	IN
cord-001835-0s7ok4uw	1338	11	the	the	DT
cord-001835-0s7ok4uw	1338	12	mass	mass	NN
cord-001835-0s7ok4uw	1338	13	distributions	distribution	NNS
cord-001835-0s7ok4uw	1338	14	obtained	obtain	VBN
cord-001835-0s7ok4uw	1338	15	in	in	IN
cord-001835-0s7ok4uw	1338	16	the	the	DT
cord-001835-0s7ok4uw	1338	17	EX1	EX1	NNP
cord-001835-0s7ok4uw	1338	18	limit	limit	NN
cord-001835-0s7ok4uw	1338	19	.	.	.
cord-001835-0s7ok4uw	1339	1	Under	under	IN
cord-001835-0s7ok4uw	1339	2	native	native	JJ
cord-001835-0s7ok4uw	1339	3	conditions	condition	NNS
cord-001835-0s7ok4uw	1339	4	,	,	,
cord-001835-0s7ok4uw	1339	5	where	where	WRB
cord-001835-0s7ok4uw	1339	6	the	the	DT
cord-001835-0s7ok4uw	1339	7	native	native	JJ
cord-001835-0s7ok4uw	1339	8	state	state	NN
cord-001835-0s7ok4uw	1339	9	is	be	VBZ
cord-001835-0s7ok4uw	1339	10	maximally	maximally	RB
cord-001835-0s7ok4uw	1339	11	stable	stable	JJ
cord-001835-0s7ok4uw	1339	12	,	,	,
cord-001835-0s7ok4uw	1339	13	the	the	DT
cord-001835-0s7ok4uw	1339	14	unfolded	unfold	VBN
cord-001835-0s7ok4uw	1339	15	state	state	NN
cord-001835-0s7ok4uw	1339	16	is	be	VBZ
cord-001835-0s7ok4uw	1339	17	transiently	transiently	RB
cord-001835-0s7ok4uw	1339	18	sampled	sample	VBN
cord-001835-0s7ok4uw	1339	19	in	in	IN
cord-001835-0s7ok4uw	1339	20	an	an	DT
cord-001835-0s7ok4uw	1339	21	entirely	entirely	RB
cord-001835-0s7ok4uw	1339	22	non	non	JJ
cord-001835-0s7ok4uw	1339	23	-	-	JJ
cord-001835-0s7ok4uw	1339	24	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	1339	25	and	and	CC
cord-001835-0s7ok4uw	1339	26	gradual	gradual	JJ
cord-001835-0s7ok4uw	1339	27	manner	manner	NN
cord-001835-0s7ok4uw	1339	28	.	.	.
cord-001835-0s7ok4uw	1340	1	Under	under	IN
cord-001835-0s7ok4uw	1340	2	conditions	condition	NNS
cord-001835-0s7ok4uw	1340	3	which	which	WDT
cord-001835-0s7ok4uw	1340	4	stabilize	stabilize	VBP
cord-001835-0s7ok4uw	1340	5	the	the	DT
cord-001835-0s7ok4uw	1340	6	unfolded	unfold	VBN
cord-001835-0s7ok4uw	1340	7	state	state	NN
cord-001835-0s7ok4uw	1340	8	or	or	CC
cord-001835-0s7ok4uw	1340	9	destabilize	destabilize	VB
cord-001835-0s7ok4uw	1340	10	the	the	DT
cord-001835-0s7ok4uw	1340	11	native	native	JJ
cord-001835-0s7ok4uw	1340	12	state	state	NN
cord-001835-0s7ok4uw	1340	13	of	of	IN
cord-001835-0s7ok4uw	1340	14	the	the	DT
cord-001835-0s7ok4uw	1340	15	protein	protein	NN
cord-001835-0s7ok4uw	1340	16	,	,	,
cord-001835-0s7ok4uw	1340	17	the	the	DT
cord-001835-0s7ok4uw	1340	18	slowest	slow	JJS
cord-001835-0s7ok4uw	1340	19	structure	structure	NN
cord-001835-0s7ok4uw	1340	20	opening	opening	NN
cord-001835-0s7ok4uw	1340	21	event	event	NN
cord-001835-0s7ok4uw	1340	22	becomes	become	VBZ
cord-001835-0s7ok4uw	1340	23	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	1340	24	.	.	.
cord-001835-0s7ok4uw	1341	1	The	the	DT
cord-001835-0s7ok4uw	1341	2	present	present	JJ
cord-001835-0s7ok4uw	1341	3	study	study	NN
cord-001835-0s7ok4uw	1341	4	provides	provide	VBZ
cord-001835-0s7ok4uw	1341	5	an	an	DT
cord-001835-0s7ok4uw	1341	6	understanding	understanding	NN
cord-001835-0s7ok4uw	1341	7	of	of	IN
cord-001835-0s7ok4uw	1341	8	the	the	DT
cord-001835-0s7ok4uw	1341	9	relationship	relationship	NN
cord-001835-0s7ok4uw	1341	10	between	between	IN
cord-001835-0s7ok4uw	1341	11	stability	stability	NN
cord-001835-0s7ok4uw	1341	12	and	and	CC
cord-001835-0s7ok4uw	1341	13	folding	fold	VBG
cord-001835-0s7ok4uw	1341	14	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	1341	15	.	.	.
cord-001835-0s7ok4uw	1342	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1342	2	suggests	suggest	VBZ
cord-001835-0s7ok4uw	1342	3	that	that	IN
cord-001835-0s7ok4uw	1342	4	the	the	DT
cord-001835-0s7ok4uw	1342	5	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	1342	6	transitions	transition	NNS
cord-001835-0s7ok4uw	1342	7	observed	observe	VBN
cord-001835-0s7ok4uw	1342	8	in	in	IN
cord-001835-0s7ok4uw	1342	9	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1342	10	reactions	reaction	NNS
cord-001835-0s7ok4uw	1342	11	maybe	maybe	RB
cord-001835-0s7ok4uw	1342	12	a	a	DT
cord-001835-0s7ok4uw	1342	13	consequence	consequence	NN
cord-001835-0s7ok4uw	1342	14	of	of	IN
cord-001835-0s7ok4uw	1342	15	the	the	DT
cord-001835-0s7ok4uw	1342	16	changes	change	NNS
cord-001835-0s7ok4uw	1342	17	in	in	IN
cord-001835-0s7ok4uw	1342	18	the	the	DT
cord-001835-0s7ok4uw	1342	19	stabilities	stability	NNS
cord-001835-0s7ok4uw	1342	20	of	of	IN
cord-001835-0s7ok4uw	1342	21	the	the	DT
cord-001835-0s7ok4uw	1342	22	unfolded	unfold	VBN
cord-001835-0s7ok4uw	1342	23	state	state	NN
cord-001835-0s7ok4uw	1342	24	and	and	CC
cord-001835-0s7ok4uw	1342	25	the	the	DT
cord-001835-0s7ok4uw	1342	26	transition	transition	NN
cord-001835-0s7ok4uw	1342	27	state	state	NN
cord-001835-0s7ok4uw	1342	28	.	.	.
cord-001835-0s7ok4uw	1343	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1343	2	also	also	RB
cord-001835-0s7ok4uw	1343	3	provides	provide	VBZ
cord-001835-0s7ok4uw	1343	4	rare	rare	JJ
cord-001835-0s7ok4uw	1343	5	experimental	experimental	JJ
cord-001835-0s7ok4uw	1343	6	evidence	evidence	NN
cord-001835-0s7ok4uw	1343	7	for	for	IN
cord-001835-0s7ok4uw	1343	8	a	a	DT
cord-001835-0s7ok4uw	1343	9	gradual	gradual	JJ
cord-001835-0s7ok4uw	1343	10	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1343	11	transition	transition	NN
cord-001835-0s7ok4uw	1343	12	on	on	IN
cord-001835-0s7ok4uw	1343	13	a	a	DT
cord-001835-0s7ok4uw	1343	14	very	very	RB
cord-001835-0s7ok4uw	1343	15	slow	slow	JJ
cord-001835-0s7ok4uw	1343	16	timescale	timescale	NN
cord-001835-0s7ok4uw	1343	17	.	.	.
cord-001835-0s7ok4uw	1344	1	Role	role	NN
cord-001835-0s7ok4uw	1344	2	of	of	IN
cord-001835-0s7ok4uw	1344	3	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	1344	4	repulsion	repulsion	NN
cord-001835-0s7ok4uw	1344	5	between	between	IN
cord-001835-0s7ok4uw	1344	6	unique	unique	JJ
cord-001835-0s7ok4uw	1344	7	arginine	arginine	NN
cord-001835-0s7ok4uw	1344	8	residues	residue	NNS
cord-001835-0s7ok4uw	1344	9	on	on	IN
cord-001835-0s7ok4uw	1344	10	the	the	DT
cord-001835-0s7ok4uw	1344	11	assembly	assembly	NN
cord-001835-0s7ok4uw	1344	12	of	of	IN
cord-001835-0s7ok4uw	1344	13	a	a	DT
cord-001835-0s7ok4uw	1344	14	trimeric	trimeric	NNP
cord-001835-0s7ok4uw	1344	15	autotransporter	autotransporter	JJ
cord-001835-0s7ok4uw	1344	16	translocator	translocator	NN
cord-001835-0s7ok4uw	1344	17	domain	domain	NN
cord-001835-0s7ok4uw	1344	18	Eriko	Eriko	NNP
cord-001835-0s7ok4uw	1344	19	Aoki	Aoki	NNP
cord-001835-0s7ok4uw	1344	20	1	1	CD
cord-001835-0s7ok4uw	1344	21	,	,	,
cord-001835-0s7ok4uw	1344	22	Kazuo	Kazuo	NNP
cord-001835-0s7ok4uw	1344	23	Fujiwara	Fujiwara	NNP
cord-001835-0s7ok4uw	1344	24	1	1	CD
cord-001835-0s7ok4uw	1344	25	,	,	,
cord-001835-0s7ok4uw	1344	26	Masamichi	Masamichi	NNP
cord-001835-0s7ok4uw	1344	27	Ikeguchi	Ikeguchi	NNP
cord-001835-0s7ok4uw	1344	28	1	1	CD
cord-001835-0s7ok4uw	1344	29	1	1	CD
cord-001835-0s7ok4uw	1344	30	Haemophilus	Haemophilus	NNP
cord-001835-0s7ok4uw	1344	31	influenzae	influenzae	NN
cord-001835-0s7ok4uw	1344	32	adhesin	adhesin	NN
cord-001835-0s7ok4uw	1344	33	(	(	-LRB-
cord-001835-0s7ok4uw	1344	34	Hia	Hia	NNP
cord-001835-0s7ok4uw	1344	35	)	)	-RRB-
cord-001835-0s7ok4uw	1344	36	belongs	belong	VBZ
cord-001835-0s7ok4uw	1344	37	to	to	IN
cord-001835-0s7ok4uw	1344	38	the	the	DT
cord-001835-0s7ok4uw	1344	39	trimeric	trimeric	NNP
cord-001835-0s7ok4uw	1344	40	autotransporter	autotransporter	NNP
cord-001835-0s7ok4uw	1344	41	family	family	NN
cord-001835-0s7ok4uw	1344	42	.	.	.
cord-001835-0s7ok4uw	1345	1	The	the	DT
cord-001835-0s7ok4uw	1345	2	autotransporter	autotransporter	NN
cord-001835-0s7ok4uw	1345	3	consists	consist	VBZ
cord-001835-0s7ok4uw	1345	4	of	of	IN
cord-001835-0s7ok4uw	1345	5	an	an	DT
cord-001835-0s7ok4uw	1345	6	N	n	CD
cord-001835-0s7ok4uw	1345	7	-	-	HYPH
cord-001835-0s7ok4uw	1345	8	terminal	terminal	NN
cord-001835-0s7ok4uw	1345	9	signal	signal	NN
cord-001835-0s7ok4uw	1345	10	peptide	peptide	NN
cord-001835-0s7ok4uw	1345	11	,	,	,
cord-001835-0s7ok4uw	1345	12	an	an	DT
cord-001835-0s7ok4uw	1345	13	internal	internal	JJ
cord-001835-0s7ok4uw	1345	14	passenger	passenger	NN
cord-001835-0s7ok4uw	1345	15	domain	domain	NN
cord-001835-0s7ok4uw	1345	16	and	and	CC
cord-001835-0s7ok4uw	1345	17	a	a	DT
cord-001835-0s7ok4uw	1345	18	C	c	NN
cord-001835-0s7ok4uw	1345	19	-	-	HYPH
cord-001835-0s7ok4uw	1345	20	terminal	terminal	NN
cord-001835-0s7ok4uw	1345	21	translocator	translocator	NN
cord-001835-0s7ok4uw	1345	22	domain	domain	NN
cord-001835-0s7ok4uw	1345	23	.	.	.
cord-001835-0s7ok4uw	1346	1	The	the	DT
cord-001835-0s7ok4uw	1346	2	signal	signal	NN
cord-001835-0s7ok4uw	1346	3	peptide	peptide	NN
cord-001835-0s7ok4uw	1346	4	directs	direct	VBZ
cord-001835-0s7ok4uw	1346	5	to	to	TO
cord-001835-0s7ok4uw	1346	6	export	export	VB
cord-001835-0s7ok4uw	1346	7	across	across	IN
cord-001835-0s7ok4uw	1346	8	the	the	DT
cord-001835-0s7ok4uw	1346	9	inner	inner	JJ
cord-001835-0s7ok4uw	1346	10	membrane	membrane	NN
cord-001835-0s7ok4uw	1346	11	via	via	IN
cord-001835-0s7ok4uw	1346	12	the	the	DT
cord-001835-0s7ok4uw	1346	13	Sec	Sec	NNP
cord-001835-0s7ok4uw	1346	14	system	system	NN
cord-001835-0s7ok4uw	1346	15	and	and	CC
cord-001835-0s7ok4uw	1346	16	is	be	VBZ
cord-001835-0s7ok4uw	1346	17	cleaved	cleave	VBN
cord-001835-0s7ok4uw	1346	18	,	,	,
cord-001835-0s7ok4uw	1346	19	the	the	DT
cord-001835-0s7ok4uw	1346	20	passenger	passenger	NN
cord-001835-0s7ok4uw	1346	21	domain	domain	NN
cord-001835-0s7ok4uw	1346	22	is	be	VBZ
cord-001835-0s7ok4uw	1346	23	a	a	DT
cord-001835-0s7ok4uw	1346	24	virulence	virulence	NN
cord-001835-0s7ok4uw	1346	25	factor	factor	NN
cord-001835-0s7ok4uw	1346	26	,	,	,
cord-001835-0s7ok4uw	1346	27	and	and	CC
cord-001835-0s7ok4uw	1346	28	the	the	DT
cord-001835-0s7ok4uw	1346	29	translocator	translocator	NN
cord-001835-0s7ok4uw	1346	30	domain	domain	NN
cord-001835-0s7ok4uw	1346	31	(	(	-LRB-
cord-001835-0s7ok4uw	1346	32	HiaT	HiaT	NNP
cord-001835-0s7ok4uw	1346	33	)	)	-RRB-
cord-001835-0s7ok4uw	1346	34	is	be	VBZ
cord-001835-0s7ok4uw	1346	35	embedded	embed	VBN
cord-001835-0s7ok4uw	1346	36	in	in	IN
cord-001835-0s7ok4uw	1346	37	the	the	DT
cord-001835-0s7ok4uw	1346	38	outer	outer	JJ
cord-001835-0s7ok4uw	1346	39	membrane	membrane	NN
cord-001835-0s7ok4uw	1346	40	.	.	.
cord-001835-0s7ok4uw	1347	1	The	the	DT
cord-001835-0s7ok4uw	1347	2	crystal	crystal	JJ
cord-001835-0s7ok4uw	1347	3	structure	structure	NN
cord-001835-0s7ok4uw	1347	4	of	of	IN
cord-001835-0s7ok4uw	1347	5	Hia	Hia	NNP
cord-001835-0s7ok4uw	1347	6	translocator	translocator	NN
cord-001835-0s7ok4uw	1347	7	domain	domain	NN
cord-001835-0s7ok4uw	1347	8	(	(	-LRB-
cord-001835-0s7ok4uw	1347	9	HiaT	HiaT	NNP
cord-001835-0s7ok4uw	1347	10	)	)	-RRB-
cord-001835-0s7ok4uw	1347	11	has	have	VBZ
cord-001835-0s7ok4uw	1347	12	shown	show	VBN
cord-001835-0s7ok4uw	1347	13	that	that	IN
cord-001835-0s7ok4uw	1347	14	HiaT	HiaT	NNP
cord-001835-0s7ok4uw	1347	15	forms	form	VBZ
cord-001835-0s7ok4uw	1347	16	a	a	DT
cord-001835-0s7ok4uw	1347	17	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	1347	18	b	b	NN
cord-001835-0s7ok4uw	1347	19	-	-	HYPH
cord-001835-0s7ok4uw	1347	20	barrel	barrel	NN
cord-001835-0s7ok4uw	1347	21	of	of	IN
cord-001835-0s7ok4uw	1347	22	12	12	CD
cord-001835-0s7ok4uw	1347	23	b	b	NN
cord-001835-0s7ok4uw	1347	24	-	-	HYPH
cord-001835-0s7ok4uw	1347	25	strands	strand	NNS
cord-001835-0s7ok4uw	1347	26	,	,	,
cord-001835-0s7ok4uw	1347	27	four	four	CD
cord-001835-0s7ok4uw	1347	28	of	of	IN
cord-001835-0s7ok4uw	1347	29	which	which	WDT
cord-001835-0s7ok4uw	1347	30	are	be	VBP
cord-001835-0s7ok4uw	1347	31	provided	provide	VBN
cord-001835-0s7ok4uw	1347	32	from	from	IN
cord-001835-0s7ok4uw	1347	33	each	each	DT
cord-001835-0s7ok4uw	1347	34	subunit	subunit	NN
cord-001835-0s7ok4uw	1347	35	.	.	.
cord-001835-0s7ok4uw	1348	1	The	the	DT
cord-001835-0s7ok4uw	1348	2	b	b	NN
cord-001835-0s7ok4uw	1348	3	-	-	HYPH
cord-001835-0s7ok4uw	1348	4	barrel	barrel	NN
cord-001835-0s7ok4uw	1348	5	has	have	VBZ
cord-001835-0s7ok4uw	1348	6	a	a	DT
cord-001835-0s7ok4uw	1348	7	pore	pore	NN
cord-001835-0s7ok4uw	1348	8	that	that	WDT
cord-001835-0s7ok4uw	1348	9	is	be	VBZ
cord-001835-0s7ok4uw	1348	10	traversed	traverse	VBN
cord-001835-0s7ok4uw	1348	11	by	by	IN
cord-001835-0s7ok4uw	1348	12	three	three	CD
cord-001835-0s7ok4uw	1348	13	a	a	DT
cord-001835-0s7ok4uw	1348	14	-	-	:
cord-001835-0s7ok4uw	1348	15	helices	helix	NNS
cord-001835-0s7ok4uw	1348	16	,	,	,
cord-001835-0s7ok4uw	1348	17	one	one	CD
cord-001835-0s7ok4uw	1348	18	of	of	IN
cord-001835-0s7ok4uw	1348	19	which	which	WDT
cord-001835-0s7ok4uw	1348	20	is	be	VBZ
cord-001835-0s7ok4uw	1348	21	provided	provide	VBN
cord-001835-0s7ok4uw	1348	22	from	from	IN
cord-001835-0s7ok4uw	1348	23	each	each	DT
cord-001835-0s7ok4uw	1348	24	subunit	subunit	NN
cord-001835-0s7ok4uw	1348	25	.	.	.
cord-001835-0s7ok4uw	1349	1	The	the	DT
cord-001835-0s7ok4uw	1349	2	protein	protein	NN
cord-001835-0s7ok4uw	1349	3	has	have	VBZ
cord-001835-0s7ok4uw	1349	4	a	a	DT
cord-001835-0s7ok4uw	1349	5	unique	unique	JJ
cord-001835-0s7ok4uw	1349	6	arginine	arginine	NN
cord-001835-0s7ok4uw	1349	7	residue	residue	NN
cord-001835-0s7ok4uw	1349	8	at	at	IN
cord-001835-0s7ok4uw	1349	9	1077	1077	CD
cord-001835-0s7ok4uw	1349	10	.	.	.
cord-001835-0s7ok4uw	1350	1	Arg1077	arg1077	JJ
cord-001835-0s7ok4uw	1350	2	side	side	NN
cord-001835-0s7ok4uw	1350	3	chains	chain	NNS
cord-001835-0s7ok4uw	1350	4	from	from	IN
cord-001835-0s7ok4uw	1350	5	three	three	CD
cord-001835-0s7ok4uw	1350	6	subunits	subunit	NNS
cord-001835-0s7ok4uw	1350	7	protrude	protrude	VBP
cord-001835-0s7ok4uw	1350	8	from	from	IN
cord-001835-0s7ok4uw	1350	9	the	the	DT
cord-001835-0s7ok4uw	1350	10	b	b	NN
cord-001835-0s7ok4uw	1350	11	-	-	HYPH
cord-001835-0s7ok4uw	1350	12	strand	strand	NN
cord-001835-0s7ok4uw	1350	13	toward	toward	IN
cord-001835-0s7ok4uw	1350	14	the	the	DT
cord-001835-0s7ok4uw	1350	15	center	center	NN
cord-001835-0s7ok4uw	1350	16	of	of	IN
cord-001835-0s7ok4uw	1350	17	the	the	DT
cord-001835-0s7ok4uw	1350	18	barrel	barrel	NN
cord-001835-0s7ok4uw	1350	19	and	and	CC
cord-001835-0s7ok4uw	1350	20	are	be	VBP
cord-001835-0s7ok4uw	1350	21	close	close	JJ
cord-001835-0s7ok4uw	1350	22	to	to	IN
cord-001835-0s7ok4uw	1350	23	each	each	DT
cord-001835-0s7ok4uw	1350	24	other	other	JJ
cord-001835-0s7ok4uw	1350	25	.	.	.
cord-001835-0s7ok4uw	1351	1	These	these	DT
cord-001835-0s7ok4uw	1351	2	residues	residue	NNS
cord-001835-0s7ok4uw	1351	3	seem	seem	VBP
cord-001835-0s7ok4uw	1351	4	to	to	TO
cord-001835-0s7ok4uw	1351	5	have	have	VB
cord-001835-0s7ok4uw	1351	6	an	an	DT
cord-001835-0s7ok4uw	1351	7	unfavorable	unfavorable	JJ
cord-001835-0s7ok4uw	1351	8	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	1351	9	effect	effect	NN
cord-001835-0s7ok4uw	1351	10	on	on	IN
cord-001835-0s7ok4uw	1351	11	the	the	DT
cord-001835-0s7ok4uw	1351	12	assembly	assembly	NN
cord-001835-0s7ok4uw	1351	13	and	and	CC
cord-001835-0s7ok4uw	1351	14	decrease	decrease	VB
cord-001835-0s7ok4uw	1351	15	the	the	DT
cord-001835-0s7ok4uw	1351	16	trimer	trimer	NN
cord-001835-0s7ok4uw	1351	17	stability	stability	NN
cord-001835-0s7ok4uw	1351	18	.	.	.
cord-001835-0s7ok4uw	1352	1	To	to	TO
cord-001835-0s7ok4uw	1352	2	investigate	investigate	VB
cord-001835-0s7ok4uw	1352	3	the	the	DT
cord-001835-0s7ok4uw	1352	4	role	role	NN
cord-001835-0s7ok4uw	1352	5	of	of	IN
cord-001835-0s7ok4uw	1352	6	this	this	DT
cord-001835-0s7ok4uw	1352	7	residue	residue	NN
cord-001835-0s7ok4uw	1352	8	on	on	IN
cord-001835-0s7ok4uw	1352	9	the	the	DT
cord-001835-0s7ok4uw	1352	10	trimer	trimer	NN
cord-001835-0s7ok4uw	1352	11	assembly	assembly	NN
cord-001835-0s7ok4uw	1352	12	and	and	CC
cord-001835-0s7ok4uw	1352	13	stability	stability	NN
cord-001835-0s7ok4uw	1352	14	of	of	IN
cord-001835-0s7ok4uw	1352	15	HiaT	HiaT	NNP
cord-001835-0s7ok4uw	1352	16	,	,	,
cord-001835-0s7ok4uw	1352	17	we	-PRON-	PRP
cord-001835-0s7ok4uw	1352	18	replaced	replace	VBD
cord-001835-0s7ok4uw	1352	19	this	this	DT
cord-001835-0s7ok4uw	1352	20	arginine	arginine	NN
cord-001835-0s7ok4uw	1352	21	with	with	IN
cord-001835-0s7ok4uw	1352	22	the	the	DT
cord-001835-0s7ok4uw	1352	23	neutral	neutral	JJ
cord-001835-0s7ok4uw	1352	24	amino	amino	NN
cord-001835-0s7ok4uw	1352	25	acid	acid	NN
cord-001835-0s7ok4uw	1352	26	,	,	,
cord-001835-0s7ok4uw	1352	27	methionine	methionine	FW
cord-001835-0s7ok4uw	1352	28	(	(	-LRB-
cord-001835-0s7ok4uw	1352	29	R1077	R1077	NNP
cord-001835-0s7ok4uw	1352	30	M	M	NNP
cord-001835-0s7ok4uw	1352	31	)	)	-RRB-
cord-001835-0s7ok4uw	1352	32	or	or	CC
cord-001835-0s7ok4uw	1352	33	the	the	DT
cord-001835-0s7ok4uw	1352	34	positively	positively	RB
cord-001835-0s7ok4uw	1352	35	charged	charge	VBN
cord-001835-0s7ok4uw	1352	36	residue	residue	NN
cord-001835-0s7ok4uw	1352	37	,	,	,
cord-001835-0s7ok4uw	1352	38	lysine	lysine	NN
cord-001835-0s7ok4uw	1352	39	(	(	-LRB-
cord-001835-0s7ok4uw	1352	40	R1077	R1077	NNP
cord-001835-0s7ok4uw	1352	41	K	K	NNP
cord-001835-0s7ok4uw	1352	42	)	)	-RRB-
cord-001835-0s7ok4uw	1352	43	,	,	,
cord-001835-0s7ok4uw	1352	44	and	and	CC
cord-001835-0s7ok4uw	1352	45	properties	property	NNS
cord-001835-0s7ok4uw	1352	46	of	of	IN
cord-001835-0s7ok4uw	1352	47	these	these	DT
cord-001835-0s7ok4uw	1352	48	mutants	mutant	NNS
cord-001835-0s7ok4uw	1352	49	were	be	VBD
cord-001835-0s7ok4uw	1352	50	investigated	investigate	VBN
cord-001835-0s7ok4uw	1352	51	.	.	.
cord-001835-0s7ok4uw	1353	1	HiaT	HiaT	NNP
cord-001835-0s7ok4uw	1353	2	and	and	CC
cord-001835-0s7ok4uw	1353	3	two	two	CD
cord-001835-0s7ok4uw	1353	4	mutants	mutant	NNS
cord-001835-0s7ok4uw	1353	5	were	be	VBD
cord-001835-0s7ok4uw	1353	6	dissociated	dissociate	VBN
cord-001835-0s7ok4uw	1353	7	by	by	IN
cord-001835-0s7ok4uw	1353	8	formic	formic	JJ
cord-001835-0s7ok4uw	1353	9	-	-	HYPH
cord-001835-0s7ok4uw	1353	10	acid	acid	NN
cord-001835-0s7ok4uw	1353	11	treatment	treatment	NN
cord-001835-0s7ok4uw	1353	12	,	,	,
cord-001835-0s7ok4uw	1353	13	and	and	CC
cord-001835-0s7ok4uw	1353	14	they	-PRON-	PRP
cord-001835-0s7ok4uw	1353	15	were	be	VBD
cord-001835-0s7ok4uw	1353	16	able	able	JJ
cord-001835-0s7ok4uw	1353	17	to	to	TO
cord-001835-0s7ok4uw	1353	18	reassemble	reassemble	VB
cord-001835-0s7ok4uw	1353	19	in	in	IN
cord-001835-0s7ok4uw	1353	20	the	the	DT
cord-001835-0s7ok4uw	1353	21	presence	presence	NN
cord-001835-0s7ok4uw	1353	22	of	of	IN
cord-001835-0s7ok4uw	1353	23	the	the	DT
cord-001835-0s7ok4uw	1353	24	detergent	detergent	NN
cord-001835-0s7ok4uw	1353	25	.	.	.
cord-001835-0s7ok4uw	1354	1	To	to	TO
cord-001835-0s7ok4uw	1354	2	measure	measure	VB
cord-001835-0s7ok4uw	1354	3	the	the	DT
cord-001835-0s7ok4uw	1354	4	time	time	NN
cord-001835-0s7ok4uw	1354	5	course	course	NN
cord-001835-0s7ok4uw	1354	6	of	of	IN
cord-001835-0s7ok4uw	1354	7	trimer	trimer	NN
cord-001835-0s7ok4uw	1354	8	reassembly	reassembly	RB
cord-001835-0s7ok4uw	1354	9	,	,	,
cord-001835-0s7ok4uw	1354	10	amounts	amount	NNS
cord-001835-0s7ok4uw	1354	11	of	of	IN
cord-001835-0s7ok4uw	1354	12	reassembled	reassemble	VBN
cord-001835-0s7ok4uw	1354	13	trimer	trimer	NN
cord-001835-0s7ok4uw	1354	14	and	and	CC
cord-001835-0s7ok4uw	1354	15	monomer	monomer	NN
cord-001835-0s7ok4uw	1354	16	were	be	VBD
cord-001835-0s7ok4uw	1354	17	quantified	quantify	VBN
cord-001835-0s7ok4uw	1354	18	by	by	IN
cord-001835-0s7ok4uw	1354	19	SDS	SDS	NNP
cord-001835-0s7ok4uw	1354	20	-	-	HYPH
cord-001835-0s7ok4uw	1354	21	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	1354	22	at	at	IN
cord-001835-0s7ok4uw	1354	23	different	different	JJ
cord-001835-0s7ok4uw	1354	24	assembly	assembly	NN
cord-001835-0s7ok4uw	1354	25	times	time	NNS
cord-001835-0s7ok4uw	1354	26	.	.	.
cord-001835-0s7ok4uw	1355	1	Although	although	IN
cord-001835-0s7ok4uw	1355	2	the	the	DT
cord-001835-0s7ok4uw	1355	3	neutralized	neutralize	VBN
cord-001835-0s7ok4uw	1355	4	mutation	mutation	NN
cord-001835-0s7ok4uw	1355	5	increased	increase	VBD
cord-001835-0s7ok4uw	1355	6	the	the	DT
cord-001835-0s7ok4uw	1355	7	rate	rate	NN
cord-001835-0s7ok4uw	1355	8	of	of	IN
cord-001835-0s7ok4uw	1355	9	reassembly	reassembly	NN
cord-001835-0s7ok4uw	1355	10	,	,	,
cord-001835-0s7ok4uw	1355	11	the	the	DT
cord-001835-0s7ok4uw	1355	12	final	final	JJ
cord-001835-0s7ok4uw	1355	13	amount	amount	NN
cord-001835-0s7ok4uw	1355	14	of	of	IN
cord-001835-0s7ok4uw	1355	15	reassembled	reassemble	VBN
cord-001835-0s7ok4uw	1355	16	trimer	trimer	NN
cord-001835-0s7ok4uw	1355	17	decreased	decrease	VBD
cord-001835-0s7ok4uw	1355	18	,	,	,
cord-001835-0s7ok4uw	1355	19	especially	especially	RB
cord-001835-0s7ok4uw	1355	20	at	at	IN
cord-001835-0s7ok4uw	1355	21	higher	high	JJR
cord-001835-0s7ok4uw	1355	22	protein	protein	NN
cord-001835-0s7ok4uw	1355	23	concentration	concentration	NN
cord-001835-0s7ok4uw	1355	24	.	.	.
cord-001835-0s7ok4uw	1356	1	These	these	DT
cord-001835-0s7ok4uw	1356	2	suggest	suggest	VBP
cord-001835-0s7ok4uw	1356	3	that	that	IN
cord-001835-0s7ok4uw	1356	4	the	the	DT
cord-001835-0s7ok4uw	1356	5	neutralized	neutralize	VBN
cord-001835-0s7ok4uw	1356	6	mutation	mutation	NN
cord-001835-0s7ok4uw	1356	7	cause	cause	VBP
cord-001835-0s7ok4uw	1356	8	the	the	DT
cord-001835-0s7ok4uw	1356	9	incorrect	incorrect	JJ
cord-001835-0s7ok4uw	1356	10	oligomer	oligomer	NNP
cord-001835-0s7ok4uw	1356	11	formation	formation	NN
cord-001835-0s7ok4uw	1356	12	.	.	.
cord-001835-0s7ok4uw	1357	1	The	the	DT
cord-001835-0s7ok4uw	1357	2	far	far	JJ
cord-001835-0s7ok4uw	1357	3	-	-	HYPH
cord-001835-0s7ok4uw	1357	4	UV	uv	NN
cord-001835-0s7ok4uw	1357	5	CD	cd	NN
cord-001835-0s7ok4uw	1357	6	spectrum	spectrum	NN
cord-001835-0s7ok4uw	1357	7	of	of	IN
cord-001835-0s7ok4uw	1358	1	reassembled	reassemble	VBN
cord-001835-0s7ok4uw	1358	2	WT	WT	NNP
cord-001835-0s7ok4uw	1358	3	HiaT	HiaT	NNP
cord-001835-0s7ok4uw	1358	4	was	be	VBD
cord-001835-0s7ok4uw	1358	5	nearly	nearly	RB
cord-001835-0s7ok4uw	1358	6	identical	identical	JJ
cord-001835-0s7ok4uw	1358	7	with	with	IN
cord-001835-0s7ok4uw	1358	8	that	that	DT
cord-001835-0s7ok4uw	1358	9	of	of	IN
cord-001835-0s7ok4uw	1358	10	the	the	DT
cord-001835-0s7ok4uw	1358	11	native	native	JJ
cord-001835-0s7ok4uw	1358	12	WT	WT	NNP
cord-001835-0s7ok4uw	1358	13	HiaT.	HiaT.	NNP
cord-001835-0s7ok4uw	1359	1	However	however	RB
cord-001835-0s7ok4uw	1359	2	,	,	,
cord-001835-0s7ok4uw	1359	3	the	the	DT
cord-001835-0s7ok4uw	1359	4	spectrum	spectrum	NN
cord-001835-0s7ok4uw	1359	5	of	of	IN
cord-001835-0s7ok4uw	1359	6	the	the	DT
cord-001835-0s7ok4uw	1359	7	reassembled	reassemble	VBN
cord-001835-0s7ok4uw	1359	8	R1077	R1077	NNP
cord-001835-0s7ok4uw	1359	9	M	M	NNP
cord-001835-0s7ok4uw	1359	10	mutant	mutant	NN
cord-001835-0s7ok4uw	1359	11	was	be	VBD
cord-001835-0s7ok4uw	1359	12	more	more	RBR
cord-001835-0s7ok4uw	1359	13	intense	intense	JJ
cord-001835-0s7ok4uw	1359	14	that	that	DT
cord-001835-0s7ok4uw	1359	15	of	of	IN
cord-001835-0s7ok4uw	1359	16	the	the	DT
cord-001835-0s7ok4uw	1359	17	native	native	JJ
cord-001835-0s7ok4uw	1359	18	R1077	R1077	NNP
cord-001835-0s7ok4uw	1359	19	M	M	NNP
cord-001835-0s7ok4uw	1359	20	mutant	mutant	NN
cord-001835-0s7ok4uw	1359	21	,	,	,
cord-001835-0s7ok4uw	1359	22	although	although	IN
cord-001835-0s7ok4uw	1359	23	the	the	DT
cord-001835-0s7ok4uw	1359	24	proportion	proportion	NN
cord-001835-0s7ok4uw	1359	25	of	of	IN
cord-001835-0s7ok4uw	1359	26	trimer	trimer	NN
cord-001835-0s7ok4uw	1359	27	was	be	VBD
cord-001835-0s7ok4uw	1359	28	much	much	RB
cord-001835-0s7ok4uw	1359	29	lower	low	JJR
cord-001835-0s7ok4uw	1359	30	than	than	IN
cord-001835-0s7ok4uw	1359	31	that	that	DT
cord-001835-0s7ok4uw	1359	32	of	of	IN
cord-001835-0s7ok4uw	1359	33	the	the	DT
cord-001835-0s7ok4uw	1359	34	WT	WT	NNP
cord-001835-0s7ok4uw	1359	35	HiaT.	HiaT.	NNP
cord-001835-0s7ok4uw	1360	1	This	this	DT
cord-001835-0s7ok4uw	1360	2	suggests	suggest	VBZ
cord-001835-0s7ok4uw	1360	3	that	that	IN
cord-001835-0s7ok4uw	1360	4	the	the	DT
cord-001835-0s7ok4uw	1360	5	incorrect	incorrect	JJ
cord-001835-0s7ok4uw	1360	6	oligomer	oligomer	NNP
cord-001835-0s7ok4uw	1360	7	has	have	VBZ
cord-001835-0s7ok4uw	1360	8	a	a	DT
cord-001835-0s7ok4uw	1360	9	secondary	secondary	JJ
cord-001835-0s7ok4uw	1360	10	structure	structure	NN
cord-001835-0s7ok4uw	1360	11	different	different	JJ
cord-001835-0s7ok4uw	1360	12	from	from	IN
cord-001835-0s7ok4uw	1360	13	the	the	DT
cord-001835-0s7ok4uw	1360	14	WT	WT	NNP
cord-001835-0s7ok4uw	1360	15	HiaT.	HiaT.	NNP
cord-001835-0s7ok4uw	1361	1	R1077	R1077	NNP
cord-001835-0s7ok4uw	1361	2	K	K	NNP
cord-001835-0s7ok4uw	1361	3	mutant	mutant	NN
cord-001835-0s7ok4uw	1361	4	showed	show	VBD
cord-001835-0s7ok4uw	1361	5	assembly	assembly	NN
cord-001835-0s7ok4uw	1361	6	properties	property	NNS
cord-001835-0s7ok4uw	1361	7	similar	similar	JJ
cord-001835-0s7ok4uw	1361	8	to	to	IN
cord-001835-0s7ok4uw	1361	9	those	those	DT
cord-001835-0s7ok4uw	1361	10	of	of	IN
cord-001835-0s7ok4uw	1361	11	the	the	DT
cord-001835-0s7ok4uw	1361	12	WT	WT	NNP
cord-001835-0s7ok4uw	1361	13	HiaT.	HiaT.	NNP
cord-001835-0s7ok4uw	1362	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	1362	2	,	,	,
cord-001835-0s7ok4uw	1362	3	the	the	DT
cord-001835-0s7ok4uw	1362	4	repulsion	repulsion	NN
cord-001835-0s7ok4uw	1362	5	between	between	IN
cord-001835-0s7ok4uw	1362	6	positively	positively	RB
cord-001835-0s7ok4uw	1362	7	charged	charge	VBN
cord-001835-0s7ok4uw	1362	8	residues	residue	NNS
cord-001835-0s7ok4uw	1362	9	seems	seem	VBZ
cord-001835-0s7ok4uw	1362	10	to	to	TO
cord-001835-0s7ok4uw	1362	11	be	be	VB
cord-001835-0s7ok4uw	1362	12	important	important	JJ
cord-001835-0s7ok4uw	1362	13	for	for	IN
cord-001835-0s7ok4uw	1362	14	preventing	prevent	VBG
cord-001835-0s7ok4uw	1362	15	HiaT	HiaT	NNP
cord-001835-0s7ok4uw	1362	16	from	from	IN
cord-001835-0s7ok4uw	1362	17	misassembly	misassembly	RB
cord-001835-0s7ok4uw	1362	18	.	.	.
cord-001835-0s7ok4uw	1363	1	Similar	similar	JJ
cord-001835-0s7ok4uw	1363	2	proximity	proximity	NN
cord-001835-0s7ok4uw	1363	3	of	of	IN
cord-001835-0s7ok4uw	1363	4	arginine	arginine	NN
cord-001835-0s7ok4uw	1363	5	residues	residue	NNS
cord-001835-0s7ok4uw	1363	6	is	be	VBZ
cord-001835-0s7ok4uw	1363	7	observed	observe	VBN
cord-001835-0s7ok4uw	1363	8	for	for	IN
cord-001835-0s7ok4uw	1363	9	HIV	HIV	NNP
cord-001835-0s7ok4uw	1363	10	capsid	capsid	NN
cord-001835-0s7ok4uw	1363	11	protein	protein	NN
cord-001835-0s7ok4uw	1363	12	,	,	,
cord-001835-0s7ok4uw	1363	13	carboxysome	carboxysome	NNP
cord-001835-0s7ok4uw	1363	14	shell	shell	NNP
cord-001835-0s7ok4uw	1363	15	protein	protein	NN
cord-001835-0s7ok4uw	1363	16	,	,	,
cord-001835-0s7ok4uw	1363	17	lumazine	lumazine	NNP
cord-001835-0s7ok4uw	1363	18	synthase	synthase	NN
cord-001835-0s7ok4uw	1363	19	and	and	CC
cord-001835-0s7ok4uw	1363	20	so	so	RB
cord-001835-0s7ok4uw	1363	21	on	on	RB
cord-001835-0s7ok4uw	1363	22	.	.	.
cord-001835-0s7ok4uw	1364	1	The	the	DT
cord-001835-0s7ok4uw	1364	2	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	1364	3	repulsion	repulsion	NN
cord-001835-0s7ok4uw	1364	4	between	between	IN
cord-001835-0s7ok4uw	1364	5	arginine	arginine	NN
cord-001835-0s7ok4uw	1364	6	residues	residue	NNS
cord-001835-0s7ok4uw	1364	7	may	may	MD
cord-001835-0s7ok4uw	1364	8	be	be	VB
cord-001835-0s7ok4uw	1364	9	a	a	DT
cord-001835-0s7ok4uw	1364	10	general	general	JJ
cord-001835-0s7ok4uw	1364	11	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1364	12	for	for	IN
cord-001835-0s7ok4uw	1364	13	protein	protein	NN
cord-001835-0s7ok4uw	1364	14	assembly	assembly	NNP
cord-001835-0s7ok4uw	1364	15	.	.	.
cord-001835-0s7ok4uw	1365	1	Department	Department	NNP
cord-001835-0s7ok4uw	1365	2	of	of	IN
cord-001835-0s7ok4uw	1365	3	Veterinary	Veterinary	NNP
cord-001835-0s7ok4uw	1365	4	Pathobiology	Pathobiology	NNP
cord-001835-0s7ok4uw	1365	5	,	,	,
cord-001835-0s7ok4uw	1365	6	Kagoshima	Kagoshima	NNP
cord-001835-0s7ok4uw	1365	7	University	University	NNP
cord-001835-0s7ok4uw	1365	8	,	,	,
cord-001835-0s7ok4uw	1365	9	2	2	CD
cord-001835-0s7ok4uw	1365	10	Institute	Institute	NNP
cord-001835-0s7ok4uw	1365	11	for	for	IN
cord-001835-0s7ok4uw	1365	12	Food	Food	NNP
cord-001835-0s7ok4uw	1365	13	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	1365	14	,	,	,
cord-001835-0s7ok4uw	1365	15	Hirosaki	Hirosaki	NNP
cord-001835-0s7ok4uw	1365	16	University	University	NNP
cord-001835-0s7ok4uw	1365	17	,	,	,
cord-001835-0s7ok4uw	1365	18	3	3	CD
cord-001835-0s7ok4uw	1365	19	Faculty	Faculty	NNP
cord-001835-0s7ok4uw	1365	20	of	of	IN
cord-001835-0s7ok4uw	1365	21	Fisheries	Fisheries	NNP
cord-001835-0s7ok4uw	1365	22	,	,	,
cord-001835-0s7ok4uw	1365	23	Kagoshima	Kagoshima	NNP
cord-001835-0s7ok4uw	1365	24	University	University	NNP
cord-001835-0s7ok4uw	1365	25	,	,	,
cord-001835-0s7ok4uw	1365	26	4	4	CD
cord-001835-0s7ok4uw	1365	27	Department	Department	NNP
cord-001835-0s7ok4uw	1365	28	of	of	IN
cord-001835-0s7ok4uw	1365	29	Veterinary	Veterinary	NNP
cord-001835-0s7ok4uw	1365	30	Histopathology	Histopathology	NNP
cord-001835-0s7ok4uw	1365	31	,	,	,
cord-001835-0s7ok4uw	1365	32	Kagoshima	Kagoshima	NNP
cord-001835-0s7ok4uw	1365	33	University	University	NNP
cord-001835-0s7ok4uw	1365	34	,	,	,
cord-001835-0s7ok4uw	1365	35	5	5	CD
cord-001835-0s7ok4uw	1365	36	Veterinary	Veterinary	NNP
cord-001835-0s7ok4uw	1365	37	Clinical	Clinical	NNP
cord-001835-0s7ok4uw	1365	38	Training	Training	NNP
cord-001835-0s7ok4uw	1365	39	Center	Center	NNP
cord-001835-0s7ok4uw	1365	40	,	,	,
cord-001835-0s7ok4uw	1365	41	Kagoshima	Kagoshima	NNP
cord-001835-0s7ok4uw	1365	42	University	University	NNP
cord-001835-0s7ok4uw	1365	43	,	,	,
cord-001835-0s7ok4uw	1365	44	6	6	CD
cord-001835-0s7ok4uw	1365	45	Department	Department	NNP
cord-001835-0s7ok4uw	1365	46	of	of	IN
cord-001835-0s7ok4uw	1365	47	Veterinary	Veterinary	NNP
cord-001835-0s7ok4uw	1365	48	Anatomy	Anatomy	NNP
cord-001835-0s7ok4uw	1365	49	,	,	,
cord-001835-0s7ok4uw	1365	50	Kagoshima	Kagoshima	NNP
cord-001835-0s7ok4uw	1365	51	University	University	NNP
cord-001835-0s7ok4uw	1365	52	,	,	,
cord-001835-0s7ok4uw	1365	53	7	7	CD
cord-001835-0s7ok4uw	1365	54	Sakamoto	Sakamoto	NNP
cord-001835-0s7ok4uw	1365	55	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1365	56	Inc.	Inc.	NNP
cord-001835-0s7ok4uw	1365	57	,	,	,
cord-001835-0s7ok4uw	1365	58	8	8	CD
cord-001835-0s7ok4uw	1366	1	The	the	DT
cord-001835-0s7ok4uw	1366	2	United	United	NNP
cord-001835-0s7ok4uw	1366	3	Graduate	Graduate	NNP
cord-001835-0s7ok4uw	1366	4	School	School	NNP
cord-001835-0s7ok4uw	1366	5	of	of	IN
cord-001835-0s7ok4uw	1366	6	Agricultural	Agricultural	NNP
cord-001835-0s7ok4uw	1366	7	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	1366	8	,	,	,
cord-001835-0s7ok4uw	1366	9	Kagoshima	Kagoshima	NNP
cord-001835-0s7ok4uw	1366	10	University	University	NNP
cord-001835-0s7ok4uw	1366	11	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1366	12	is	be	VBZ
cord-001835-0s7ok4uw	1366	13	a	a	DT
cord-001835-0s7ok4uw	1366	14	traditional	traditional	JJ
cord-001835-0s7ok4uw	1366	15	Japanese	japanese	JJ
cord-001835-0s7ok4uw	1366	16	rice	rice	NN
cord-001835-0s7ok4uw	1366	17	vinegar	vinegar	NN
cord-001835-0s7ok4uw	1366	18	.	.	.
cord-001835-0s7ok4uw	1367	1	During	during	IN
cord-001835-0s7ok4uw	1367	2	fermentation	fermentation	NN
cord-001835-0s7ok4uw	1367	3	and	and	CC
cord-001835-0s7ok4uw	1367	4	aging	aging	NN
cord-001835-0s7ok4uw	1367	5	of	of	IN
cord-001835-0s7ok4uw	1367	6	the	the	DT
cord-001835-0s7ok4uw	1367	7	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1367	8	liquid	liquid	NN
cord-001835-0s7ok4uw	1367	9	in	in	IN
cord-001835-0s7ok4uw	1367	10	an	an	DT
cord-001835-0s7ok4uw	1367	11	earthenware	earthenware	JJ
cord-001835-0s7ok4uw	1367	12	jar	jar	NN
cord-001835-0s7ok4uw	1367	13	over	over	IN
cord-001835-0s7ok4uw	1367	14	1	1	CD
cord-001835-0s7ok4uw	1367	15	year	year	NN
cord-001835-0s7ok4uw	1367	16	,	,	,
cord-001835-0s7ok4uw	1367	17	solid	solid	JJ
cord-001835-0s7ok4uw	1367	18	residue	residue	NN
cord-001835-0s7ok4uw	1367	19	called	call	VBN
cord-001835-0s7ok4uw	1367	20	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1367	21	Moromi	Moromi	NNP
cord-001835-0s7ok4uw	1367	22	is	be	VBZ
cord-001835-0s7ok4uw	1367	23	produced	produce	VBN
cord-001835-0s7ok4uw	1367	24	.	.	.
cord-001835-0s7ok4uw	1368	1	In	in	IN
cord-001835-0s7ok4uw	1368	2	the	the	DT
cord-001835-0s7ok4uw	1368	3	present	present	JJ
cord-001835-0s7ok4uw	1368	4	study	study	NN
cord-001835-0s7ok4uw	1368	5	,	,	,
cord-001835-0s7ok4uw	1368	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	1368	7	evaluated	evaluate	VBD
cord-001835-0s7ok4uw	1368	8	whether	whether	IN
cord-001835-0s7ok4uw	1368	9	concentrated	concentrated	JJ
cord-001835-0s7ok4uw	1368	10	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1368	11	or	or	CC
cord-001835-0s7ok4uw	1368	12	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1368	13	Moromi	Moromi	NNP
cord-001835-0s7ok4uw	1368	14	could	could	MD
cord-001835-0s7ok4uw	1368	15	ameliorate	ameliorate	VB
cord-001835-0s7ok4uw	1368	16	cognitive	cognitive	JJ
cord-001835-0s7ok4uw	1368	17	dysfunction	dysfunction	NN
cord-001835-0s7ok4uw	1368	18	in	in	IN
cord-001835-0s7ok4uw	1368	19	the	the	DT
cord-001835-0s7ok4uw	1368	20	senescence	senescence	NN
cord-001835-0s7ok4uw	1368	21	accelerated	accelerate	VBD
cord-001835-0s7ok4uw	1368	22	P8	P8	NNP
cord-001835-0s7ok4uw	1368	23	mouse	mouse	NN
cord-001835-0s7ok4uw	1368	24	.	.	.
cord-001835-0s7ok4uw	1369	1	Senescence	senescence	NN
cord-001835-0s7ok4uw	1369	2	accelerated	accelerate	VBD
cord-001835-0s7ok4uw	1369	3	P8	P8	NNP
cord-001835-0s7ok4uw	1369	4	mice	mouse	NNS
cord-001835-0s7ok4uw	1369	5	were	be	VBD
cord-001835-0s7ok4uw	1369	6	fed	feed	VBN
cord-001835-0s7ok4uw	1369	7	0.25	0.25	CD
cord-001835-0s7ok4uw	1369	8	%	%	NN
cord-001835-0s7ok4uw	1369	9	(	(	-LRB-
cord-001835-0s7ok4uw	1369	10	w	w	NNP
cord-001835-0s7ok4uw	1369	11	/	/	SYM
cord-001835-0s7ok4uw	1369	12	w	w	NN
cord-001835-0s7ok4uw	1369	13	)	)	-RRB-
cord-001835-0s7ok4uw	1369	14	concentrated	concentrate	VBD
cord-001835-0s7ok4uw	1369	15	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1369	16	or	or	CC
cord-001835-0s7ok4uw	1369	17	0.5	0.5	CD
cord-001835-0s7ok4uw	1369	18	%	%	NN
cord-001835-0s7ok4uw	1370	1	(	(	-LRB-
cord-001835-0s7ok4uw	1370	2	w	w	NNP
cord-001835-0s7ok4uw	1370	3	/	/	SYM
cord-001835-0s7ok4uw	1370	4	w	w	NN
cord-001835-0s7ok4uw	1370	5	)	)	-RRB-
cord-001835-0s7ok4uw	1370	6	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1370	7	Moromi	Moromi	NNP
cord-001835-0s7ok4uw	1370	8	for	for	IN
cord-001835-0s7ok4uw	1370	9	4	4	CD
cord-001835-0s7ok4uw	1370	10	or	or	CC
cord-001835-0s7ok4uw	1370	11	25	25	CD
cord-001835-0s7ok4uw	1370	12	weeks	week	NNS
cord-001835-0s7ok4uw	1370	13	.	.	.
cord-001835-0s7ok4uw	1371	1	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1371	2	suppressed	suppress	VBD
cord-001835-0s7ok4uw	1371	3	cognitive	cognitive	JJ
cord-001835-0s7ok4uw	1371	4	dysfunction	dysfunction	NN
cord-001835-0s7ok4uw	1371	5	and	and	CC
cord-001835-0s7ok4uw	1371	6	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1371	7	accumulation	accumulation	NN
cord-001835-0s7ok4uw	1371	8	in	in	IN
cord-001835-0s7ok4uw	1371	9	the	the	DT
cord-001835-0s7ok4uw	1371	10	brain	brain	NN
cord-001835-0s7ok4uw	1371	11	,	,	,
cord-001835-0s7ok4uw	1371	12	while	while	IN
cord-001835-0s7ok4uw	1371	13	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1371	14	Moromi	Moromi	NNP
cord-001835-0s7ok4uw	1371	15	showed	show	VBD
cord-001835-0s7ok4uw	1371	16	a	a	DT
cord-001835-0s7ok4uw	1371	17	tendency	tendency	NN
cord-001835-0s7ok4uw	1371	18	to	to	TO
cord-001835-0s7ok4uw	1371	19	ameliorate	ameliorate	VB
cord-001835-0s7ok4uw	1371	20	cognitive	cognitive	JJ
cord-001835-0s7ok4uw	1371	21	dysfunction	dysfunction	NN
cord-001835-0s7ok4uw	1371	22	,	,	,
cord-001835-0s7ok4uw	1371	23	but	but	CC
cord-001835-0s7ok4uw	1371	24	the	the	DT
cord-001835-0s7ok4uw	1371	25	effect	effect	NN
cord-001835-0s7ok4uw	1371	26	was	be	VBD
cord-001835-0s7ok4uw	1371	27	not	not	RB
cord-001835-0s7ok4uw	1371	28	significant	significant	JJ
cord-001835-0s7ok4uw	1371	29	.	.	.
cord-001835-0s7ok4uw	1372	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1372	2	hypothesize	hypothesize	VBP
cord-001835-0s7ok4uw	1372	3	the	the	DT
cord-001835-0s7ok4uw	1372	4	effect	effect	NN
cord-001835-0s7ok4uw	1372	5	is	be	VBZ
cord-001835-0s7ok4uw	1372	6	caused	cause	VBN
cord-001835-0s7ok4uw	1372	7	by	by	IN
cord-001835-0s7ok4uw	1372	8	the	the	DT
cord-001835-0s7ok4uw	1372	9	antioxidant	antioxidant	JJ
cord-001835-0s7ok4uw	1372	10	effect	effect	NN
cord-001835-0s7ok4uw	1372	11	of	of	IN
cord-001835-0s7ok4uw	1372	12	concentrated	concentrated	JJ
cord-001835-0s7ok4uw	1372	13	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1372	14	,	,	,
cord-001835-0s7ok4uw	1372	15	however	however	RB
cord-001835-0s7ok4uw	1372	16	,	,	,
cord-001835-0s7ok4uw	1372	17	the	the	DT
cord-001835-0s7ok4uw	1372	18	level	level	NN
cord-001835-0s7ok4uw	1372	19	of	of	IN
cord-001835-0s7ok4uw	1372	20	lipid	lipid	NN
cord-001835-0s7ok4uw	1372	21	peroxidation	peroxidation	NN
cord-001835-0s7ok4uw	1372	22	in	in	IN
cord-001835-0s7ok4uw	1372	23	the	the	DT
cord-001835-0s7ok4uw	1372	24	brain	brain	NN
cord-001835-0s7ok4uw	1372	25	did	do	VBD
cord-001835-0s7ok4uw	1372	26	not	not	RB
cord-001835-0s7ok4uw	1372	27	differ	differ	VB
cord-001835-0s7ok4uw	1372	28	in	in	IN
cord-001835-0s7ok4uw	1372	29	senescence	senescence	NN
cord-001835-0s7ok4uw	1372	30	accelerated	accelerate	VBD
cord-001835-0s7ok4uw	1372	31	P8	P8	NNP
cord-001835-0s7ok4uw	1372	32	mice	mouse	NNS
cord-001835-0s7ok4uw	1372	33	.	.	.
cord-001835-0s7ok4uw	1373	1	DNA	dna	NN
cord-001835-0s7ok4uw	1373	2	microarray	microarray	NN
cord-001835-0s7ok4uw	1373	3	analysis	analysis	NN
cord-001835-0s7ok4uw	1373	4	indicated	indicate	VBD
cord-001835-0s7ok4uw	1373	5	that	that	IN
cord-001835-0s7ok4uw	1373	6	concentrated	concentrate	VBN
cord-001835-0s7ok4uw	1373	7	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1373	8	increased	increase	VBD
cord-001835-0s7ok4uw	1373	9	HSPA1A	HSPA1A	NNP
cord-001835-0s7ok4uw	1373	10	mRNA	mrna	NN
cord-001835-0s7ok4uw	1373	11	expression	expression	NN
cord-001835-0s7ok4uw	1373	12	,	,	,
cord-001835-0s7ok4uw	1373	13	a	a	DT
cord-001835-0s7ok4uw	1373	14	protein	protein	NN
cord-001835-0s7ok4uw	1373	15	that	that	WDT
cord-001835-0s7ok4uw	1373	16	prevents	prevent	VBZ
cord-001835-0s7ok4uw	1373	17	protein	protein	NN
cord-001835-0s7ok4uw	1373	18	misfolding	misfolding	NN
cord-001835-0s7ok4uw	1373	19	and	and	CC
cord-001835-0s7ok4uw	1373	20	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1373	21	.	.	.
cord-001835-0s7ok4uw	1374	1	The	the	DT
cord-001835-0s7ok4uw	1374	2	increase	increase	NN
cord-001835-0s7ok4uw	1374	3	in	in	IN
cord-001835-0s7ok4uw	1374	4	HSPA1A	hspa1a	JJ
cord-001835-0s7ok4uw	1374	5	expression	expression	NN
cord-001835-0s7ok4uw	1374	6	by	by	IN
cord-001835-0s7ok4uw	1374	7	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1374	8	was	be	VBD
cord-001835-0s7ok4uw	1374	9	confirmed	confirm	VBN
cord-001835-0s7ok4uw	1374	10	using	use	VBG
cord-001835-0s7ok4uw	1374	11	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	1374	12	real	real	JJ
cord-001835-0s7ok4uw	1374	13	-	-	HYPH
cord-001835-0s7ok4uw	1374	14	time	time	NN
cord-001835-0s7ok4uw	1374	15	PCR	PCR	NNP
cord-001835-0s7ok4uw	1374	16	and	and	CC
cord-001835-0s7ok4uw	1374	17	immunoblotting	immunoblotting	NN
cord-001835-0s7ok4uw	1374	18	methods	method	NNS
cord-001835-0s7ok4uw	1374	19	.	.	.
cord-001835-0s7ok4uw	1375	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	1375	2	,	,	,
cord-001835-0s7ok4uw	1375	3	the	the	DT
cord-001835-0s7ok4uw	1375	4	suppression	suppression	NN
cord-001835-0s7ok4uw	1375	5	of	of	IN
cord-001835-0s7ok4uw	1375	6	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1375	7	accumulation	accumulation	NN
cord-001835-0s7ok4uw	1375	8	by	by	IN
cord-001835-0s7ok4uw	1375	9	concentrated	concentrated	JJ
cord-001835-0s7ok4uw	1375	10	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1375	11	may	may	MD
cord-001835-0s7ok4uw	1375	12	be	be	VB
cord-001835-0s7ok4uw	1375	13	associated	associate	VBN
cord-001835-0s7ok4uw	1375	14	with	with	IN
cord-001835-0s7ok4uw	1375	15	HSPA1A	HSPA1A	NNP
cord-001835-0s7ok4uw	1375	16	induction	induction	NN
cord-001835-0s7ok4uw	1375	17	.	.	.
cord-001835-0s7ok4uw	1376	1	However	however	RB
cord-001835-0s7ok4uw	1376	2	,	,	,
cord-001835-0s7ok4uw	1376	3	concentrated	concentrated	JJ
cord-001835-0s7ok4uw	1376	4	Kurozu	Kurozu	NNP
cord-001835-0s7ok4uw	1376	5	could	could	MD
cord-001835-0s7ok4uw	1376	6	not	not	RB
cord-001835-0s7ok4uw	1376	7	increase	increase	VB
cord-001835-0s7ok4uw	1376	8	HSPA1A	hspa1a	JJ
cord-001835-0s7ok4uw	1376	9	expression	expression	NN
cord-001835-0s7ok4uw	1376	10	in	in	IN
cord-001835-0s7ok4uw	1376	11	mouse	mouse	NN
cord-001835-0s7ok4uw	1376	12	primary	primary	JJ
cord-001835-0s7ok4uw	1376	13	neurons	neuron	NNS
cord-001835-0s7ok4uw	1376	14	,	,	,
cord-001835-0s7ok4uw	1376	15	suggesting	suggest	VBG
cord-001835-0s7ok4uw	1376	16	it	-PRON-	PRP
cord-001835-0s7ok4uw	1376	17	may	may	MD
cord-001835-0s7ok4uw	1376	18	not	not	RB
cord-001835-0s7ok4uw	1376	19	directly	directly	RB
cord-001835-0s7ok4uw	1376	20	affect	affect	VB
cord-001835-0s7ok4uw	1376	21	neurons	neuron	NNS
cord-001835-0s7ok4uw	1376	22	.	.	.
cord-001835-0s7ok4uw	1377	1	Young	Young	NNP
cord-001835-0s7ok4uw	1377	2	-	-	HYPH
cord-001835-0s7ok4uw	1377	3	Ho	Ho	NNP
cord-001835-0s7ok4uw	1377	4	Lee	Lee	NNP
cord-001835-0s7ok4uw	1377	5	1	1	CD
cord-001835-0s7ok4uw	1378	1	Although	although	IN
cord-001835-0s7ok4uw	1378	2	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1378	3	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1378	4	are	be	VBP
cord-001835-0s7ok4uw	1378	5	associated	associate	VBN
cord-001835-0s7ok4uw	1378	6	with	with	IN
cord-001835-0s7ok4uw	1378	7	a	a	DT
cord-001835-0s7ok4uw	1378	8	number	number	NN
cord-001835-0s7ok4uw	1378	9	of	of	IN
cord-001835-0s7ok4uw	1378	10	pathologies	pathology	NNS
cord-001835-0s7ok4uw	1378	11	,	,	,
cord-001835-0s7ok4uw	1378	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1378	13	conformational	conformational	JJ
cord-001835-0s7ok4uw	1378	14	stability	stability	NN
cord-001835-0s7ok4uw	1378	15	remains	remain	VBZ
cord-001835-0s7ok4uw	1378	16	largely	largely	RB
cord-001835-0s7ok4uw	1378	17	unclear	unclear	JJ
cord-001835-0s7ok4uw	1378	18	.	.	.
cord-001835-0s7ok4uw	1379	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1379	2	herein	herein	RB
cord-001835-0s7ok4uw	1379	3	investigated	investigate	VBD
cord-001835-0s7ok4uw	1379	4	the	the	DT
cord-001835-0s7ok4uw	1379	5	thermal	thermal	JJ
cord-001835-0s7ok4uw	1379	6	stability	stability	NN
cord-001835-0s7ok4uw	1379	7	of	of	IN
cord-001835-0s7ok4uw	1379	8	various	various	JJ
cord-001835-0s7ok4uw	1379	9	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1379	10	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1379	11	.	.	.
cord-001835-0s7ok4uw	1380	1	a	a	LS
cord-001835-0s7ok4uw	1380	2	-	-	HYPH
cord-001835-0s7ok4uw	1380	3	Synuclein	Synuclein	NNP
cord-001835-0s7ok4uw	1380	4	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1380	5	,	,	,
cord-001835-0s7ok4uw	1380	6	freshly	freshly	RB
cord-001835-0s7ok4uw	1380	7	prepared	prepare	VBN
cord-001835-0s7ok4uw	1380	8	at	at	IN
cord-001835-0s7ok4uw	1380	9	37	37	CD
cord-001835-0s7ok4uw	1380	10	C	c	NN
cord-001835-0s7ok4uw	1380	11	at	at	IN
cord-001835-0s7ok4uw	1380	12	neutral	neutral	JJ
cord-001835-0s7ok4uw	1380	13	pH	pH	NNP
cord-001835-0s7ok4uw	1380	14	,	,	,
cord-001835-0s7ok4uw	1380	15	cold	cold	JJ
cord-001835-0s7ok4uw	1380	16	-	-	HYPH
cord-001835-0s7ok4uw	1380	17	denatured	denature	VBN
cord-001835-0s7ok4uw	1380	18	to	to	IN
cord-001835-0s7ok4uw	1380	19	monomers	monomer	NNS
cord-001835-0s7ok4uw	1380	20	at	at	IN
cord-001835-0s7ok4uw	1380	21	0	0	CD
cord-001835-0s7ok4uw	1380	22	-	-	SYM
cord-001835-0s7ok4uw	1380	23	20	20	CD
cord-001835-0s7ok4uw	1380	24	C	c	NN
cord-001835-0s7ok4uw	1380	25	and	and	CC
cord-001835-0s7ok4uw	1380	26	heat	heat	NN
cord-001835-0s7ok4uw	1380	27	-	-	HYPH
cord-001835-0s7ok4uw	1380	28	denatured	denature	VBN
cord-001835-0s7ok4uw	1380	29	at	at	IN
cord-001835-0s7ok4uw	1380	30	60	60	CD
cord-001835-0s7ok4uw	1380	31	-	-	SYM
cord-001835-0s7ok4uw	1380	32	110	110	CD
cord-001835-0s7ok4uw	1380	33	C.	c.	NN
cord-001835-0s7ok4uw	1381	1	Meanwhile	meanwhile	RB
cord-001835-0s7ok4uw	1381	2	,	,	,
cord-001835-0s7ok4uw	1381	3	the	the	DT
cord-001835-0s7ok4uw	1381	4	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1381	5	of	of	IN
cord-001835-0s7ok4uw	1381	6	b2-microglobulin	b2-microglobulin	NNP
cord-001835-0s7ok4uw	1381	7	,	,	,
cord-001835-0s7ok4uw	1381	8	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	1381	9	's	's	POS
cord-001835-0s7ok4uw	1381	10	Ab1	ab1	NN
cord-001835-0s7ok4uw	1381	11	-	-	SYM
cord-001835-0s7ok4uw	1381	12	40	40	CD
cord-001835-0s7ok4uw	1381	13	/	/	SYM
cord-001835-0s7ok4uw	1381	14	Ab1	ab1	CD
cord-001835-0s7ok4uw	1381	15	-	-	SYM
cord-001835-0s7ok4uw	1381	16	42	42	CD
cord-001835-0s7ok4uw	1381	17	peptides	peptide	NNS
cord-001835-0s7ok4uw	1381	18	,	,	,
cord-001835-0s7ok4uw	1381	19	and	and	CC
cord-001835-0s7ok4uw	1381	20	insulin	insulin	NN
cord-001835-0s7ok4uw	1381	21	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	1381	22	only	only	RB
cord-001835-0s7ok4uw	1381	23	heat	heat	NN
cord-001835-0s7ok4uw	1381	24	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1381	25	,	,	,
cord-001835-0s7ok4uw	1381	26	although	although	IN
cord-001835-0s7ok4uw	1381	27	they	-PRON-	PRP
cord-001835-0s7ok4uw	1381	28	showed	show	VBD
cord-001835-0s7ok4uw	1381	29	a	a	DT
cord-001835-0s7ok4uw	1381	30	decrease	decrease	NN
cord-001835-0s7ok4uw	1381	31	in	in	IN
cord-001835-0s7ok4uw	1381	32	conformational	conformational	JJ
cord-001835-0s7ok4uw	1381	33	stability	stability	NN
cord-001835-0s7ok4uw	1381	34	at	at	IN
cord-001835-0s7ok4uw	1381	35	low	low	JJ
cord-001835-0s7ok4uw	1381	36	temperature	temperature	NN
cord-001835-0s7ok4uw	1381	37	in	in	IN
cord-001835-0s7ok4uw	1381	38	the	the	DT
cord-001835-0s7ok4uw	1381	39	presence	presence	NN
cord-001835-0s7ok4uw	1381	40	of	of	IN
cord-001835-0s7ok4uw	1381	41	chemical	chemical	NN
cord-001835-0s7ok4uw	1381	42	denaturants	denaturant	NNS
cord-001835-0s7ok4uw	1381	43	.	.	.
cord-001835-0s7ok4uw	1382	1	A	a	DT
cord-001835-0s7ok4uw	1382	2	comparison	comparison	NN
cord-001835-0s7ok4uw	1382	3	of	of	IN
cord-001835-0s7ok4uw	1382	4	structural	structural	JJ
cord-001835-0s7ok4uw	1382	5	parameters	parameter	NNS
cord-001835-0s7ok4uw	1382	6	with	with	IN
cord-001835-0s7ok4uw	1382	7	positive	positive	JJ
cord-001835-0s7ok4uw	1382	8	enthalpy	enthalpy	NN
cord-001835-0s7ok4uw	1382	9	and	and	CC
cord-001835-0s7ok4uw	1382	10	heat	heat	NN
cord-001835-0s7ok4uw	1382	11	capacity	capacity	NN
cord-001835-0s7ok4uw	1382	12	changes	change	NNS
cord-001835-0s7ok4uw	1382	13	which	which	WDT
cord-001835-0s7ok4uw	1382	14	showed	show	VBD
cord-001835-0s7ok4uw	1382	15	opposite	opposite	JJ
cord-001835-0s7ok4uw	1382	16	signs	sign	NNS
cord-001835-0s7ok4uw	1382	17	to	to	IN
cord-001835-0s7ok4uw	1382	18	protein	protein	NN
cord-001835-0s7ok4uw	1382	19	folding	folding	NN
cord-001835-0s7ok4uw	1382	20	suggested	suggest	VBD
cord-001835-0s7ok4uw	1382	21	that	that	IN
cord-001835-0s7ok4uw	1382	22	the	the	DT
cord-001835-0s7ok4uw	1382	23	burial	burial	NN
cord-001835-0s7ok4uw	1382	24	of	of	IN
cord-001835-0s7ok4uw	1382	25	charged	charged	JJ
cord-001835-0s7ok4uw	1382	26	residues	residue	NNS
cord-001835-0s7ok4uw	1382	27	in	in	IN
cord-001835-0s7ok4uw	1382	28	the	the	DT
cord-001835-0s7ok4uw	1382	29	fibril	fibril	NNP
cord-001835-0s7ok4uw	1382	30	cores	core	NNS
cord-001835-0s7ok4uw	1382	31	contributed	contribute	VBD
cord-001835-0s7ok4uw	1382	32	to	to	IN
cord-001835-0s7ok4uw	1382	33	the	the	DT
cord-001835-0s7ok4uw	1382	34	cold	cold	JJ
cord-001835-0s7ok4uw	1382	35	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1382	36	of	of	IN
cord-001835-0s7ok4uw	1382	37	a	a	DT
cord-001835-0s7ok4uw	1382	38	-	-	HYPH
cord-001835-0s7ok4uw	1382	39	synuclein	synuclein	NN
cord-001835-0s7ok4uw	1382	40	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1382	41	.	.	.
cord-001835-0s7ok4uw	1383	1	Reinforced	reinforce	VBN
cord-001835-0s7ok4uw	1383	2	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	1383	3	repulsion	repulsion	NN
cord-001835-0s7ok4uw	1383	4	at	at	IN
cord-001835-0s7ok4uw	1383	5	low	low	JJ
cord-001835-0s7ok4uw	1383	6	temperatures	temperature	NNS
cord-001835-0s7ok4uw	1383	7	may	may	MD
cord-001835-0s7ok4uw	1383	8	promote	promote	VB
cord-001835-0s7ok4uw	1383	9	cold	cold	JJ
cord-001835-0s7ok4uw	1383	10	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1383	11	,	,	,
cord-001835-0s7ok4uw	1383	12	leading	lead	VBG
cord-001835-0s7ok4uw	1383	13	to	to	IN
cord-001835-0s7ok4uw	1383	14	a	a	DT
cord-001835-0s7ok4uw	1383	15	unique	unique	JJ
cord-001835-0s7ok4uw	1383	16	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1383	17	property	property	NN
cord-001835-0s7ok4uw	1383	18	of	of	IN
cord-001835-0s7ok4uw	1383	19	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1383	20	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1383	21	.	.	.
cord-001835-0s7ok4uw	1384	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1384	2	propose	propose	VBP
cord-001835-0s7ok4uw	1384	3	that	that	IN
cord-001835-0s7ok4uw	1384	4	although	although	IN
cord-001835-0s7ok4uw	1384	5	cold	cold	JJ
cord-001835-0s7ok4uw	1384	6	-	-	HYPH
cord-001835-0s7ok4uw	1384	7	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1384	8	is	be	VBZ
cord-001835-0s7ok4uw	1384	9	common	common	JJ
cord-001835-0s7ok4uw	1384	10	to	to	IN
cord-001835-0s7ok4uw	1384	11	both	both	DT
cord-001835-0s7ok4uw	1384	12	native	native	JJ
cord-001835-0s7ok4uw	1384	13	proteins	protein	NNS
cord-001835-0s7ok4uw	1384	14	and	and	CC
cord-001835-0s7ok4uw	1384	15	misfolded	misfolde	VBD
cord-001835-0s7ok4uw	1384	16	fibrillar	fibrillar	NNP
cord-001835-0s7ok4uw	1384	17	states	state	NNS
cord-001835-0s7ok4uw	1384	18	,	,	,
cord-001835-0s7ok4uw	1384	19	the	the	DT
cord-001835-0s7ok4uw	1384	20	main	main	JJ
cord-001835-0s7ok4uw	1384	21	-	-	HYPH
cord-001835-0s7ok4uw	1384	22	chain	chain	NN
cord-001835-0s7ok4uw	1384	23	dominated	dominate	VBN
cord-001835-0s7ok4uw	1384	24	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1384	25	structures	structure	NNS
cord-001835-0s7ok4uw	1384	26	may	may	MD
cord-001835-0s7ok4uw	1384	27	explain	explain	VB
cord-001835-0s7ok4uw	1384	28	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1384	29	-	-	HYPH
cord-001835-0s7ok4uw	1384	30	specific	specific	JJ
cord-001835-0s7ok4uw	1384	31	cold	cold	JJ
cord-001835-0s7ok4uw	1384	32	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1384	33	due	due	IN
cord-001835-0s7ok4uw	1384	34	to	to	IN
cord-001835-0s7ok4uw	1384	35	the	the	DT
cord-001835-0s7ok4uw	1384	36	unfavorable	unfavorable	JJ
cord-001835-0s7ok4uw	1384	37	burial	burial	NN
cord-001835-0s7ok4uw	1384	38	of	of	IN
cord-001835-0s7ok4uw	1384	39	charged	charge	VBN
cord-001835-0s7ok4uw	1384	40	side	side	NN
cord-001835-0s7ok4uw	1384	41	-	-	HYPH
cord-001835-0s7ok4uw	1384	42	chains	chain	NNS
cord-001835-0s7ok4uw	1384	43	in	in	IN
cord-001835-0s7ok4uw	1384	44	fibril	fibril	NNP
cord-001835-0s7ok4uw	1384	45	cores	core	NNS
cord-001835-0s7ok4uw	1384	46	.	.	.
cord-001835-0s7ok4uw	1385	1	Key	key	JJ
cord-001835-0s7ok4uw	1385	2	structural	structural	JJ
cord-001835-0s7ok4uw	1385	3	differences	difference	NNS
cord-001835-0s7ok4uw	1385	4	between	between	IN
cord-001835-0s7ok4uw	1385	5	TbTIM	TbTIM	NNP
cord-001835-0s7ok4uw	1385	6	and	and	CC
cord-001835-0s7ok4uw	1385	7	TcTIM	TcTIM	NNP
cord-001835-0s7ok4uw	1385	8	revealed	reveal	VBD
cord-001835-0s7ok4uw	1385	9	by	by	IN
cord-001835-0s7ok4uw	1385	10	thermal	thermal	JJ
cord-001835-0s7ok4uw	1385	11	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1385	12	molecular	molecular	JJ
cord-001835-0s7ok4uw	1385	13	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1385	14	simulations	simulation	NNS
cord-001835-0s7ok4uw	1385	15	Angel	Angel	NNP
cord-001835-0s7ok4uw	1385	16	Piñeiro	Piñeiro	NNP
cord-001835-0s7ok4uw	1385	17	1	1	CD
cord-001835-0s7ok4uw	1385	18	,	,	,
cord-001835-0s7ok4uw	1385	19	Miguel	Miguel	NNP
cord-001835-0s7ok4uw	1385	20	Costas	Costas	NNP
cord-001835-0s7ok4uw	1385	21	2	2	CD
cord-001835-0s7ok4uw	1385	22	,	,	,
cord-001835-0s7ok4uw	1386	1	Andrea	Andrea	NNP
cord-001835-0s7ok4uw	1386	2	Guti	Guti	NNP
cord-001835-0s7ok4uw	1386	3	errez	errez	NNP
cord-001835-0s7ok4uw	1386	4	-	-	HYPH
cord-001835-0s7ok4uw	1386	5	Quezada	Quezada	NNP
cord-001835-0s7ok4uw	1386	6	2	2	CD
cord-001835-0s7ok4uw	1386	7	1	1	CD
cord-001835-0s7ok4uw	1386	8	Dept	Dept	NNP
cord-001835-0s7ok4uw	1386	9	of	of	IN
cord-001835-0s7ok4uw	1386	10	Applied	Applied	NNP
cord-001835-0s7ok4uw	1386	11	Physics	Physics	NNP
cord-001835-0s7ok4uw	1386	12	,	,	,
cord-001835-0s7ok4uw	1386	13	University	University	NNP
cord-001835-0s7ok4uw	1386	14	of	of	IN
cord-001835-0s7ok4uw	1386	15	Santiago	Santiago	NNP
cord-001835-0s7ok4uw	1386	16	de	de	NNP
cord-001835-0s7ok4uw	1386	17	Compostela	Compostela	NNP
cord-001835-0s7ok4uw	1386	18	,	,	,
cord-001835-0s7ok4uw	1386	19	2	2	CD
cord-001835-0s7ok4uw	1386	20	Lab	lab	NN
cord-001835-0s7ok4uw	1386	21	.	.	.
cord-001835-0s7ok4uw	1386	22	of	of	IN
cord-001835-0s7ok4uw	1386	23	Biophys	Biophys	NNP
cord-001835-0s7ok4uw	1386	24	.	.	.
cord-001835-0s7ok4uw	1387	1	Chem	Chem	NNP
cord-001835-0s7ok4uw	1387	2	.	.	.
cord-001835-0s7ok4uw	1388	1	,	,	,
cord-001835-0s7ok4uw	1388	2	Dept	Dept	NNP
cord-001835-0s7ok4uw	1388	3	of	of	IN
cord-001835-0s7ok4uw	1388	4	Physical	Physical	NNP
cord-001835-0s7ok4uw	1388	5	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	1388	6	,	,	,
cord-001835-0s7ok4uw	1388	7	Fac	Fac	NNP
cord-001835-0s7ok4uw	1388	8	.	.	.
cord-001835-0s7ok4uw	1389	1	of	of	IN
cord-001835-0s7ok4uw	1389	2	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	1389	3	,	,	,
cord-001835-0s7ok4uw	1389	4	UNAM	UNAM	NNP
cord-001835-0s7ok4uw	1389	5	The	the	DT
cord-001835-0s7ok4uw	1389	6	thermal	thermal	JJ
cord-001835-0s7ok4uw	1389	7	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1389	8	pattern	pattern	NN
cord-001835-0s7ok4uw	1389	9	obtained	obtain	VBN
cord-001835-0s7ok4uw	1389	10	by	by	IN
cord-001835-0s7ok4uw	1389	11	differential	differential	JJ
cord-001835-0s7ok4uw	1389	12	scanning	scanning	NN
cord-001835-0s7ok4uw	1389	13	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	1389	14	for	for	IN
cord-001835-0s7ok4uw	1389	15	Trypanosoma	Trypanosoma	NNP
cord-001835-0s7ok4uw	1389	16	cruzi	cruzi	NNP
cord-001835-0s7ok4uw	1389	17	and	and	CC
cord-001835-0s7ok4uw	1389	18	Trypanosoma	Trypanosoma	NNP
cord-001835-0s7ok4uw	1389	19	brucei	brucei	NNP
cord-001835-0s7ok4uw	1389	20	triosephosphate	triosephosphate	NNP
cord-001835-0s7ok4uw	1389	21	isomerase	isomerase	NN
cord-001835-0s7ok4uw	1389	22	(	(	-LRB-
cord-001835-0s7ok4uw	1389	23	TcIM	TcIM	NNP
cord-001835-0s7ok4uw	1389	24	and	and	CC
cord-001835-0s7ok4uw	1389	25	TcTIM	TcTIM	NNP
cord-001835-0s7ok4uw	1389	26	)	)	-RRB-
cord-001835-0s7ok4uw	1389	27	are	be	VBP
cord-001835-0s7ok4uw	1389	28	significantly	significantly	RB
cord-001835-0s7ok4uw	1389	29	different	different	JJ
cord-001835-0s7ok4uw	1389	30	although	although	IN
cord-001835-0s7ok4uw	1389	31	the	the	DT
cord-001835-0s7ok4uw	1389	32	crystal	crystal	NN
cord-001835-0s7ok4uw	1389	33	structure	structure	NN
cord-001835-0s7ok4uw	1389	34	of	of	IN
cord-001835-0s7ok4uw	1389	35	both	both	DT
cord-001835-0s7ok4uw	1389	36	proteins	protein	NNS
cord-001835-0s7ok4uw	1389	37	is	be	VBZ
cord-001835-0s7ok4uw	1389	38	almost	almost	RB
cord-001835-0s7ok4uw	1389	39	indistinguishable	indistinguishable	JJ
cord-001835-0s7ok4uw	1389	40	and	and	CC
cord-001835-0s7ok4uw	1389	41	the	the	DT
cord-001835-0s7ok4uw	1389	42	sequences	sequence	NNS
cord-001835-0s7ok4uw	1389	43	are	be	VBP
cord-001835-0s7ok4uw	1389	44	highly	highly	RB
cord-001835-0s7ok4uw	1389	45	homogolous	homogolous	JJ
cord-001835-0s7ok4uw	1389	46	.	.	.
cord-001835-0s7ok4uw	1390	1	In	in	IN
cord-001835-0s7ok4uw	1390	2	order	order	NN
cord-001835-0s7ok4uw	1390	3	to	to	TO
cord-001835-0s7ok4uw	1390	4	explain	explain	VB
cord-001835-0s7ok4uw	1390	5	these	these	DT
cord-001835-0s7ok4uw	1390	6	differences	difference	NNS
cord-001835-0s7ok4uw	1390	7	at	at	IN
cord-001835-0s7ok4uw	1390	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	1390	9	level	level	NN
cord-001835-0s7ok4uw	1390	10	a	a	DT
cord-001835-0s7ok4uw	1390	11	set	set	NN
cord-001835-0s7ok4uw	1390	12	of	of	IN
cord-001835-0s7ok4uw	1390	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	1390	14	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1390	15	simulations	simulation	NNS
cord-001835-0s7ok4uw	1390	16	were	be	VBD
cord-001835-0s7ok4uw	1390	17	performed	perform	VBN
cord-001835-0s7ok4uw	1390	18	at	at	IN
cord-001835-0s7ok4uw	1390	19	different	different	JJ
cord-001835-0s7ok4uw	1390	20	temperatures	temperature	NNS
cord-001835-0s7ok4uw	1390	21	between	between	IN
cord-001835-0s7ok4uw	1390	22	400	400	CD
cord-001835-0s7ok4uw	1390	23	and	and	CC
cord-001835-0s7ok4uw	1390	24	700	700	CD
cord-001835-0s7ok4uw	1390	25	K.	K.	NNP
cord-001835-0s7ok4uw	1391	1	The	the	DT
cord-001835-0s7ok4uw	1391	2	obtained	obtain	VBN
cord-001835-0s7ok4uw	1391	3	trajectories	trajectory	NNS
cord-001835-0s7ok4uw	1391	4	were	be	VBD
cord-001835-0s7ok4uw	1391	5	analyzed	analyze	VBN
cord-001835-0s7ok4uw	1391	6	in	in	IN
cord-001835-0s7ok4uw	1391	7	detail	detail	NN
cord-001835-0s7ok4uw	1391	8	and	and	CC
cord-001835-0s7ok4uw	1391	9	the	the	DT
cord-001835-0s7ok4uw	1391	10	residues	residue	NNS
cord-001835-0s7ok4uw	1391	11	that	that	WDT
cord-001835-0s7ok4uw	1391	12	showed	show	VBD
cord-001835-0s7ok4uw	1391	13	to	to	TO
cord-001835-0s7ok4uw	1391	14	be	be	VB
cord-001835-0s7ok4uw	1391	15	key	key	JJ
cord-001835-0s7ok4uw	1391	16	in	in	IN
cord-001835-0s7ok4uw	1391	17	the	the	DT
cord-001835-0s7ok4uw	1391	18	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1391	19	pathway	pathway	NN
cord-001835-0s7ok4uw	1391	20	of	of	IN
cord-001835-0s7ok4uw	1391	21	each	each	DT
cord-001835-0s7ok4uw	1391	22	species	specie	NNS
cord-001835-0s7ok4uw	1391	23	were	be	VBD
cord-001835-0s7ok4uw	1391	24	identified	identify	VBN
cord-001835-0s7ok4uw	1391	25	.	.	.
cord-001835-0s7ok4uw	1392	1	A	a	DT
cord-001835-0s7ok4uw	1392	2	set	set	NN
cord-001835-0s7ok4uw	1392	3	of	of	IN
cord-001835-0s7ok4uw	1392	4	residues	residue	NNS
cord-001835-0s7ok4uw	1392	5	that	that	WDT
cord-001835-0s7ok4uw	1392	6	behave	behave	VBP
cord-001835-0s7ok4uw	1392	7	significantly	significantly	RB
cord-001835-0s7ok4uw	1392	8	different	different	JJ
cord-001835-0s7ok4uw	1392	9	between	between	IN
cord-001835-0s7ok4uw	1392	10	both	both	DT
cord-001835-0s7ok4uw	1392	11	proteins	protein	NNS
cord-001835-0s7ok4uw	1392	12	were	be	VBD
cord-001835-0s7ok4uw	1392	13	selected	select	VBN
cord-001835-0s7ok4uw	1392	14	and	and	CC
cord-001835-0s7ok4uw	1392	15	proposed	propose	VBN
cord-001835-0s7ok4uw	1392	16	for	for	IN
cord-001835-0s7ok4uw	1392	17	mutations	mutation	NNS
cord-001835-0s7ok4uw	1392	18	.	.	.
cord-001835-0s7ok4uw	1393	1	The	the	DT
cord-001835-0s7ok4uw	1393	2	general	general	JJ
cord-001835-0s7ok4uw	1393	3	aim	aim	NN
cord-001835-0s7ok4uw	1393	4	is	be	VBZ
cord-001835-0s7ok4uw	1393	5	to	to	TO
cord-001835-0s7ok4uw	1393	6	identify	identify	VB
cord-001835-0s7ok4uw	1393	7	the	the	DT
cord-001835-0s7ok4uw	1393	8	minimum	minimum	NN
cord-001835-0s7ok4uw	1393	9	amount	amount	NN
cord-001835-0s7ok4uw	1393	10	of	of	IN
cord-001835-0s7ok4uw	1393	11	residue	residue	NN
cord-001835-0s7ok4uw	1393	12	mutations	mutation	NNS
cord-001835-0s7ok4uw	1393	13	that	that	WDT
cord-001835-0s7ok4uw	1393	14	allow	allow	VBP
cord-001835-0s7ok4uw	1393	15	providing	provide	VBG
cord-001835-0s7ok4uw	1393	16	TbTIM	TbTIM	NNP
cord-001835-0s7ok4uw	1393	17	with	with	IN
cord-001835-0s7ok4uw	1393	18	the	the	DT
cord-001835-0s7ok4uw	1393	19	behaviour	behaviour	NN
cord-001835-0s7ok4uw	1393	20	of	of	IN
cord-001835-0s7ok4uw	1393	21	TcTIM	TcTIM	NNP
cord-001835-0s7ok4uw	1393	22	and	and	CC
cord-001835-0s7ok4uw	1393	23	vice	vice	NN
cord-001835-0s7ok4uw	1393	24	versa	versa	RB
cord-001835-0s7ok4uw	1393	25	.	.	.
cord-001835-0s7ok4uw	1394	1	Experimental	experimental	JJ
cord-001835-0s7ok4uw	1394	2	complementary	complementary	JJ
cord-001835-0s7ok4uw	1394	3	work	work	NN
cord-001835-0s7ok4uw	1394	4	is	be	VBZ
cord-001835-0s7ok4uw	1394	5	also	also	RB
cord-001835-0s7ok4uw	1394	6	being	be	VBG
cord-001835-0s7ok4uw	1394	7	performed	perform	VBN
cord-001835-0s7ok4uw	1394	8	on	on	IN
cord-001835-0s7ok4uw	1394	9	the	the	DT
cord-001835-0s7ok4uw	1394	10	same	same	JJ
cord-001835-0s7ok4uw	1394	11	protein	protein	NN
cord-001835-0s7ok4uw	1394	12	.	.	.
cord-001835-0s7ok4uw	1395	1	Repositioning	reposition	VBG
cord-001835-0s7ok4uw	1395	2	SOM0226	SOM0226	NNP
cord-001835-0s7ok4uw	1395	3	as	as	IN
cord-001835-0s7ok4uw	1395	4	a	a	DT
cord-001835-0s7ok4uw	1395	5	potent	potent	JJ
cord-001835-0s7ok4uw	1395	6	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	1395	7	of	of	IN
cord-001835-0s7ok4uw	1395	8	transthyretin	transthyretin	NNP
cord-001835-0s7ok4uw	1395	9	amyloidogenesis	amyloidogenesis	NNP
cord-001835-0s7ok4uw	1395	10	and	and	CC
cord-001835-0s7ok4uw	1395	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1395	12	associated	associate	VBN
cord-001835-0s7ok4uw	1395	13	cellular	cellular	JJ
cord-001835-0s7ok4uw	1395	14	toxicity	toxicity	NN
cord-001835-0s7ok4uw	1395	15	Salvador	Salvador	NNP
cord-001835-0s7ok4uw	1395	16	Ventura	Ventura	NNP
cord-001835-0s7ok4uw	1395	17	1	1	CD
cord-001835-0s7ok4uw	1395	18	,	,	,
cord-001835-0s7ok4uw	1395	19	Ricardo	Ricardo	NNP
cord-001835-0s7ok4uw	1395	20	Sant'Anna	Sant'Anna	NNP
cord-001835-0s7ok4uw	1395	21	1	1	CD
cord-001835-0s7ok4uw	1395	22	,	,	,
cord-001835-0s7ok4uw	1395	23	Maria	Maria	NNP
cord-001835-0s7ok4uw	1395	24	Ros	Ros	NNP
cord-001835-0s7ok4uw	1395	25	ario	ario	NN
cord-001835-0s7ok4uw	1395	26	Almeida	Almeida	NNP
cord-001835-0s7ok4uw	1395	27	2	2	CD
cord-001835-0s7ok4uw	1396	1	,	,	,
cord-001835-0s7ok4uw	1396	2	Nat	Nat	NNP
cord-001835-0s7ok4uw	1396	3	alia	alia	VBD
cord-001835-0s7ok4uw	1396	4	Reixach	Reixach	NNP
cord-001835-0s7ok4uw	1396	5	3	3	CD
cord-001835-0s7ok4uw	1396	6	,	,	,
cord-001835-0s7ok4uw	1396	7	Raul	Raul	NNP
cord-001835-0s7ok4uw	1396	8	Insa	Insa	NNP
cord-001835-0s7ok4uw	1396	9	4	4	CD
cord-001835-0s7ok4uw	1396	10	,	,	,
cord-001835-0s7ok4uw	1396	11	Adrian	Adrian	NNP
cord-001835-0s7ok4uw	1396	12	Velazquez	Velazquez	NNP
cord-001835-0s7ok4uw	1396	13	-	-	HYPH
cord-001835-0s7ok4uw	1396	14	Campoy	Campoy	NNP
cord-001835-0s7ok4uw	1396	15	5	5	CD
cord-001835-0s7ok4uw	1396	16	,	,	,
cord-001835-0s7ok4uw	1396	17	David	David	NNP
cord-001835-0s7ok4uw	1396	18	Reverter	Reverter	NNP
cord-001835-0s7ok4uw	1396	19	1	1	CD
cord-001835-0s7ok4uw	1396	20	,	,	,
cord-001835-0s7ok4uw	1396	21	N	n	CD
cord-001835-0s7ok4uw	1396	22	uria	uria	NNP
cord-001835-0s7ok4uw	1396	23	Reig	Reig	NNP
cord-001835-0s7ok4uw	1396	24	4	4	CD
cord-001835-0s7ok4uw	1396	25	1	1	CD
cord-001835-0s7ok4uw	1396	26	Universitat	Universitat	NNP
cord-001835-0s7ok4uw	1396	27	Aut	Aut	NNP
cord-001835-0s7ok4uw	1396	28	onoma	onoma	NN
cord-001835-0s7ok4uw	1396	29	de	de	NNP
cord-001835-0s7ok4uw	1396	30	Barcelona	Barcelona	NNP
cord-001835-0s7ok4uw	1396	31	,	,	,
cord-001835-0s7ok4uw	1396	32	2	2	CD
cord-001835-0s7ok4uw	1396	33	Instituto	Instituto	NNP
cord-001835-0s7ok4uw	1396	34	de	de	NNP
cord-001835-0s7ok4uw	1396	35	Biologia	Biologia	NNP
cord-001835-0s7ok4uw	1396	36	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	1396	37	e	e	NNP
cord-001835-0s7ok4uw	1396	38	Celular	Celular	NNP
cord-001835-0s7ok4uw	1396	39	,	,	,
cord-001835-0s7ok4uw	1396	40	ICBAS	ICBAS	NNP
cord-001835-0s7ok4uw	1396	41	,	,	,
cord-001835-0s7ok4uw	1396	42	3	3	CD
cord-001835-0s7ok4uw	1397	1	The	the	DT
cord-001835-0s7ok4uw	1397	2	Scripps	Scripps	NNP
cord-001835-0s7ok4uw	1397	3	Research	Research	NNP
cord-001835-0s7ok4uw	1397	4	Institute	Institute	NNP
cord-001835-0s7ok4uw	1397	5	,	,	,
cord-001835-0s7ok4uw	1397	6	4	4	CD
cord-001835-0s7ok4uw	1397	7	SOM	SOM	NNP
cord-001835-0s7ok4uw	1397	8	-	-	HYPH
cord-001835-0s7ok4uw	1397	9	Biotech	Biotech	NNP
cord-001835-0s7ok4uw	1397	10	,	,	,
cord-001835-0s7ok4uw	1397	11	5	5	CD
cord-001835-0s7ok4uw	1397	12	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	1397	13	de	de	IN
cord-001835-0s7ok4uw	1397	14	Zaragoza	Zaragoza	NNP
cord-001835-0s7ok4uw	1397	15	Transthyretin	Transthyretin	NNP
cord-001835-0s7ok4uw	1397	16	(	(	-LRB-
cord-001835-0s7ok4uw	1397	17	TTR	TTR	NNP
cord-001835-0s7ok4uw	1397	18	)	)	-RRB-
cord-001835-0s7ok4uw	1397	19	is	be	VBZ
cord-001835-0s7ok4uw	1397	20	a	a	DT
cord-001835-0s7ok4uw	1397	21	plasma	plasma	NN
cord-001835-0s7ok4uw	1397	22	homotetrameric	homotetrameric	NN
cord-001835-0s7ok4uw	1397	23	protein	protein	NN
cord-001835-0s7ok4uw	1397	24	implicated	implicate	VBN
cord-001835-0s7ok4uw	1397	25	in	in	IN
cord-001835-0s7ok4uw	1397	26	fatal	fatal	JJ
cord-001835-0s7ok4uw	1397	27	amyloidosis	amyloidosis	NN
cord-001835-0s7ok4uw	1397	28	.	.	.
cord-001835-0s7ok4uw	1398	1	TTR	TTR	NNP
cord-001835-0s7ok4uw	1398	2	tetramer	tetramer	NN
cord-001835-0s7ok4uw	1398	3	dissociation	dissociation	NN
cord-001835-0s7ok4uw	1398	4	precedes	precede	VBZ
cord-001835-0s7ok4uw	1398	5	pathological	pathological	JJ
cord-001835-0s7ok4uw	1398	6	TTR	TTR	NNP
cord-001835-0s7ok4uw	1398	7	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1398	8	.	.	.
cord-001835-0s7ok4uw	1399	1	Despite	despite	IN
cord-001835-0s7ok4uw	1399	2	TTR	TTR	NNP
cord-001835-0s7ok4uw	1399	3	stabilizers	stabilizer	NNS
cord-001835-0s7ok4uw	1399	4	are	be	VBP
cord-001835-0s7ok4uw	1399	5	promising	promise	VBG
cord-001835-0s7ok4uw	1399	6	drugs	drug	NNS
cord-001835-0s7ok4uw	1399	7	to	to	TO
cord-001835-0s7ok4uw	1399	8	treat	treat	VB
cord-001835-0s7ok4uw	1399	9	TTR	TTR	NNP
cord-001835-0s7ok4uw	1399	10	amyloidoses	amyloidose	NNS
cord-001835-0s7ok4uw	1399	11	,	,	,
cord-001835-0s7ok4uw	1399	12	none	none	NN
cord-001835-0s7ok4uw	1399	13	of	of	IN
cord-001835-0s7ok4uw	1399	14	them	-PRON-	PRP
cord-001835-0s7ok4uw	1399	15	is	be	VBZ
cord-001835-0s7ok4uw	1399	16	approved	approve	VBN
cord-001835-0s7ok4uw	1399	17	by	by	IN
cord-001835-0s7ok4uw	1399	18	the	the	DT
cord-001835-0s7ok4uw	1399	19	Food	Food	NNP
cord-001835-0s7ok4uw	1399	20	and	and	CC
cord-001835-0s7ok4uw	1399	21	Drug	Drug	NNP
cord-001835-0s7ok4uw	1399	22	Administration	Administration	NNP
cord-001835-0s7ok4uw	1399	23	(	(	-LRB-
cord-001835-0s7ok4uw	1399	24	FDA	FDA	NNP
cord-001835-0s7ok4uw	1399	25	)	)	-RRB-
cord-001835-0s7ok4uw	1399	26	.	.	.
cord-001835-0s7ok4uw	1400	1	Repositioning	reposition	VBG
cord-001835-0s7ok4uw	1400	2	existing	exist	VBG
cord-001835-0s7ok4uw	1400	3	drugs	drug	NNS
cord-001835-0s7ok4uw	1400	4	for	for	IN
cord-001835-0s7ok4uw	1400	5	new	new	JJ
cord-001835-0s7ok4uw	1400	6	indications	indication	NNS
cord-001835-0s7ok4uw	1400	7	is	be	VBZ
cord-001835-0s7ok4uw	1400	8	becoming	become	VBG
cord-001835-0s7ok4uw	1400	9	increasingly	increasingly	RB
cord-001835-0s7ok4uw	1400	10	important	important	JJ
cord-001835-0s7ok4uw	1400	11	in	in	IN
cord-001835-0s7ok4uw	1400	12	drug	drug	NN
cord-001835-0s7ok4uw	1400	13	development	development	NN
cord-001835-0s7ok4uw	1400	14	.	.	.
cord-001835-0s7ok4uw	1401	1	Here	here	RB
cord-001835-0s7ok4uw	1401	2	,	,	,
cord-001835-0s7ok4uw	1401	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1401	4	repurposed	repurpose	VBD
cord-001835-0s7ok4uw	1401	5	SOM0226	som0226	NN
cord-001835-0s7ok4uw	1401	6	,	,	,
cord-001835-0s7ok4uw	1401	7	an	an	DT
cord-001835-0s7ok4uw	1401	8	FDA	FDA	NNP
cord-001835-0s7ok4uw	1401	9	-	-	HYPH
cord-001835-0s7ok4uw	1401	10	approved	approve	VBN
cord-001835-0s7ok4uw	1401	11	molecule	molecule	NN
cord-001835-0s7ok4uw	1401	12	for	for	IN
cord-001835-0s7ok4uw	1401	13	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	1401	14	diseases	disease	NNS
cord-001835-0s7ok4uw	1401	15	,	,	,
cord-001835-0s7ok4uw	1401	16	as	as	IN
cord-001835-0s7ok4uw	1401	17	a	a	DT
cord-001835-0s7ok4uw	1401	18	very	very	RB
cord-001835-0s7ok4uw	1401	19	potent	potent	JJ
cord-001835-0s7ok4uw	1401	20	TTR	TTR	NNP
cord-001835-0s7ok4uw	1401	21	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1401	22	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	1401	23	.	.	.
cord-001835-0s7ok4uw	1402	1	SOM0226	SOM0226	NNP
cord-001835-0s7ok4uw	1402	2	binds	bind	VBZ
cord-001835-0s7ok4uw	1402	3	specifically	specifically	RB
cord-001835-0s7ok4uw	1402	4	to	to	IN
cord-001835-0s7ok4uw	1402	5	TTR	TTR	NNP
cord-001835-0s7ok4uw	1402	6	in	in	IN
cord-001835-0s7ok4uw	1402	7	human	human	JJ
cord-001835-0s7ok4uw	1402	8	plasma	plasma	NN
cord-001835-0s7ok4uw	1402	9	,	,	,
cord-001835-0s7ok4uw	1402	10	stabilizes	stabilize	VBZ
cord-001835-0s7ok4uw	1402	11	the	the	DT
cord-001835-0s7ok4uw	1402	12	tetramer	tetramer	NN
cord-001835-0s7ok4uw	1402	13	in	in	IN
cord-001835-0s7ok4uw	1402	14	vivo	vivo	NNP
cord-001835-0s7ok4uw	1402	15	and	and	CC
cord-001835-0s7ok4uw	1402	16	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	1402	17	TTR	TTR	NNP
cord-001835-0s7ok4uw	1402	18	cytotoxicity	cytotoxicity	NN
cord-001835-0s7ok4uw	1402	19	.	.	.
cord-001835-0s7ok4uw	1403	1	In	in	IN
cord-001835-0s7ok4uw	1403	2	contrast	contrast	NN
cord-001835-0s7ok4uw	1403	3	to	to	IN
cord-001835-0s7ok4uw	1403	4	most	most	JJS
cord-001835-0s7ok4uw	1403	5	TTR	TTR	NNP
cord-001835-0s7ok4uw	1403	6	stabilizers	stabilizer	NNS
cord-001835-0s7ok4uw	1403	7	,	,	,
cord-001835-0s7ok4uw	1403	8	it	-PRON-	PRP
cord-001835-0s7ok4uw	1403	9	exhibits	exhibit	VBZ
cord-001835-0s7ok4uw	1403	10	high	high	JJ
cord-001835-0s7ok4uw	1403	11	affinity	affinity	NN
cord-001835-0s7ok4uw	1403	12	for	for	IN
cord-001835-0s7ok4uw	1403	13	both	both	DT
cord-001835-0s7ok4uw	1403	14	TTR	TTR	NNP
cord-001835-0s7ok4uw	1403	15	thyroxine	thyroxine	NN
cord-001835-0s7ok4uw	1403	16	-binding	-binding	NN
cord-001835-0s7ok4uw	1403	17	sites	site	NNS
cord-001835-0s7ok4uw	1403	18	.	.	.
cord-001835-0s7ok4uw	1404	1	The	the	DT
cord-001835-0s7ok4uw	1404	2	crystal	crystal	NN
cord-001835-0s7ok4uw	1404	3	structure	structure	NN
cord-001835-0s7ok4uw	1404	4	of	of	IN
cord-001835-0s7ok4uw	1404	5	SOM0226-bound	SOM0226-bound	NNP
cord-001835-0s7ok4uw	1405	1	TTR	TTR	NNP
cord-001835-0s7ok4uw	1405	2	explains	explain	VBZ
cord-001835-0s7ok4uw	1405	3	why	why	WRB
cord-001835-0s7ok4uw	1405	4	this	this	DT
cord-001835-0s7ok4uw	1405	5	molecule	molecule	NN
cord-001835-0s7ok4uw	1405	6	is	be	VBZ
cord-001835-0s7ok4uw	1405	7	a	a	DT
cord-001835-0s7ok4uw	1405	8	better	well	JJR
cord-001835-0s7ok4uw	1405	9	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1405	10	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	1405	11	than	than	IN
cord-001835-0s7ok4uw	1405	12	Tafamidis	Tafamidis	NNP
cord-001835-0s7ok4uw	1405	13	,	,	,
cord-001835-0s7ok4uw	1405	14	so	so	RB
cord-001835-0s7ok4uw	1405	15	far	far	RB
cord-001835-0s7ok4uw	1405	16	the	the	DT
cord-001835-0s7ok4uw	1405	17	only	only	JJ
cord-001835-0s7ok4uw	1405	18	drug	drug	NN
cord-001835-0s7ok4uw	1405	19	in	in	IN
cord-001835-0s7ok4uw	1405	20	the	the	DT
cord-001835-0s7ok4uw	1405	21	market	market	NN
cord-001835-0s7ok4uw	1405	22	to	to	TO
cord-001835-0s7ok4uw	1405	23	treat	treat	VB
cord-001835-0s7ok4uw	1405	24	the	the	DT
cord-001835-0s7ok4uw	1405	25	TTR	TTR	NNP
cord-001835-0s7ok4uw	1405	26	amyloidoses	amyloidose	NNS
cord-001835-0s7ok4uw	1405	27	.	.	.
cord-001835-0s7ok4uw	1406	1	Overall	overall	RB
cord-001835-0s7ok4uw	1406	2	,	,	,
cord-001835-0s7ok4uw	1406	3	SOM0226	SOM0226	NNP
cord-001835-0s7ok4uw	1406	4	,	,	,
cord-001835-0s7ok4uw	1406	5	already	already	RB
cord-001835-0s7ok4uw	1406	6	in	in	IN
cord-001835-0s7ok4uw	1406	7	clinical	clinical	JJ
cord-001835-0s7ok4uw	1406	8	trials	trial	NNS
cord-001835-0s7ok4uw	1406	9	,	,	,
cord-001835-0s7ok4uw	1406	10	is	be	VBZ
cord-001835-0s7ok4uw	1406	11	a	a	DT
cord-001835-0s7ok4uw	1406	12	strong	strong	JJ
cord-001835-0s7ok4uw	1406	13	candidate	candidate	NN
cord-001835-0s7ok4uw	1406	14	for	for	IN
cord-001835-0s7ok4uw	1406	15	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	1406	16	intervention	intervention	NN
cord-001835-0s7ok4uw	1406	17	in	in	IN
cord-001835-0s7ok4uw	1406	18	these	these	DT
cord-001835-0s7ok4uw	1406	19	diseases	disease	NNS
cord-001835-0s7ok4uw	1406	20	.	.	.
cord-001835-0s7ok4uw	1407	1	Neurometals	neurometal	NNS
cord-001835-0s7ok4uw	1407	2	as	as	IN
cord-001835-0s7ok4uw	1407	3	modulators	modulator	NNS
cord-001835-0s7ok4uw	1407	4	of	of	IN
cord-001835-0s7ok4uw	1407	5	protein	protein	NN
cord-001835-0s7ok4uw	1407	6	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1407	7	in	in	IN
cord-001835-0s7ok4uw	1407	8	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	1407	9	diseases	disease	NNS
cord-001835-0s7ok4uw	1408	1	S	S	NNP
cord-001835-0s7ok4uw	1408	2	onia	onia	NNP
cord-001835-0s7ok4uw	1408	3	S.	S.	NNP
cord-001835-0s7ok4uw	1408	4	Leal	Leal	NNP
cord-001835-0s7ok4uw	1408	5	1	1	CD
cord-001835-0s7ok4uw	1408	6	,	,	,
cord-001835-0s7ok4uw	1408	7	Joana	Joana	NNP
cord-001835-0s7ok4uw	1408	8	S.	S.	NNP
cord-001835-0s7ok4uw	1408	9	Crist	Crist	NNP
cord-001835-0s7ok4uw	1408	10	ovão	ovão	VBZ
cord-001835-0s7ok4uw	1408	11	1	1	CD
cord-001835-0s7ok4uw	1408	12	,	,	,
cord-001835-0s7ok4uw	1409	1	Cl	Cl	NNP
cord-001835-0s7ok4uw	1409	2	audio	audio	NN
cord-001835-0s7ok4uw	1409	3	M.	M.	NNP
cord-001835-0s7ok4uw	1409	4	Gomes	Gomes	NNP
cord-001835-0s7ok4uw	1410	1	1	1	CD
cord-001835-0s7ok4uw	1410	2	1	1	CD
cord-001835-0s7ok4uw	1410	3	Protein	protein	NN
cord-001835-0s7ok4uw	1410	4	misfolding	misfolding	NN
cord-001835-0s7ok4uw	1410	5	and	and	CC
cord-001835-0s7ok4uw	1410	6	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1410	7	is	be	VBZ
cord-001835-0s7ok4uw	1410	8	a	a	DT
cord-001835-0s7ok4uw	1410	9	hallmark	hallmark	NN
cord-001835-0s7ok4uw	1410	10	across	across	IN
cord-001835-0s7ok4uw	1410	11	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	1410	12	diseases	disease	NNS
cord-001835-0s7ok4uw	1410	13	such	such	JJ
cord-001835-0s7ok4uw	1410	14	as	as	IN
cord-001835-0s7ok4uw	1410	15	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	1410	16	's	's	POS
cord-001835-0s7ok4uw	1410	17	disease	disease	NN
cord-001835-0s7ok4uw	1410	18	and	and	CC
cord-001835-0s7ok4uw	1410	19	Amyotrophic	amyotrophic	JJ
cord-001835-0s7ok4uw	1410	20	lateral	lateral	JJ
cord-001835-0s7ok4uw	1410	21	sclerosis	sclerosis	NN
cord-001835-0s7ok4uw	1410	22	(	(	-LRB-
cord-001835-0s7ok4uw	1410	23	ALS	ALS	NNP
cord-001835-0s7ok4uw	1410	24	)	)	-RRB-
cord-001835-0s7ok4uw	1410	25	.	.	.
cord-001835-0s7ok4uw	1411	1	Since	since	IN
cord-001835-0s7ok4uw	1411	2	these	these	DT
cord-001835-0s7ok4uw	1411	3	diseases	disease	NNS
cord-001835-0s7ok4uw	1411	4	are	be	VBP
cord-001835-0s7ok4uw	1411	5	mostly	mostly	RB
cord-001835-0s7ok4uw	1411	6	sporadic	sporadic	JJ
cord-001835-0s7ok4uw	1411	7	,	,	,
cord-001835-0s7ok4uw	1411	8	the	the	DT
cord-001835-0s7ok4uw	1411	9	formation	formation	NN
cord-001835-0s7ok4uw	1411	10	of	of	IN
cord-001835-0s7ok4uw	1411	11	protein	protein	NN
cord-001835-0s7ok4uw	1411	12	amyloids	amyloid	NNS
cord-001835-0s7ok4uw	1411	13	in	in	IN
cord-001835-0s7ok4uw	1411	14	the	the	DT
cord-001835-0s7ok4uw	1411	15	nervous	nervous	JJ
cord-001835-0s7ok4uw	1411	16	system	system	NN
cord-001835-0s7ok4uw	1411	17	depends	depend	VBZ
cord-001835-0s7ok4uw	1411	18	of	of	IN
cord-001835-0s7ok4uw	1411	19	chemical	chemical	NN
cord-001835-0s7ok4uw	1411	20	and	and	CC
cord-001835-0s7ok4uw	1411	21	biological	biological	JJ
cord-001835-0s7ok4uw	1411	22	triggers	trigger	NNS
cord-001835-0s7ok4uw	1411	23	within	within	IN
cord-001835-0s7ok4uw	1411	24	the	the	DT
cord-001835-0s7ok4uw	1411	25	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	1411	26	environment	environment	NN
cord-001835-0s7ok4uw	1411	27	,	,	,
cord-001835-0s7ok4uw	1411	28	such	such	JJ
cord-001835-0s7ok4uw	1411	29	as	as	IN
cord-001835-0s7ok4uw	1411	30	metal	metal	NN
cord-001835-0s7ok4uw	1411	31	ions	ion	NNS
cord-001835-0s7ok4uw	1411	32	[	[	-LRB-
cord-001835-0s7ok4uw	1411	33	1	1	CD
cord-001835-0s7ok4uw	1411	34	]	]	-RRB-
cord-001835-0s7ok4uw	1411	35	.	.	.
cord-001835-0s7ok4uw	1412	1	In	in	IN
cord-001835-0s7ok4uw	1412	2	this	this	DT
cord-001835-0s7ok4uw	1412	3	communication	communication	NN
cord-001835-0s7ok4uw	1412	4	I	-PRON-	PRP
cord-001835-0s7ok4uw	1412	5	will	will	MD
cord-001835-0s7ok4uw	1412	6	overview	overview	VB
cord-001835-0s7ok4uw	1412	7	the	the	DT
cord-001835-0s7ok4uw	1412	8	metallobiology	metallobiology	NN
cord-001835-0s7ok4uw	1412	9	of	of	IN
cord-001835-0s7ok4uw	1412	10	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	1412	11	calcium	calcium	NN
cord-001835-0s7ok4uw	1412	12	,	,	,
cord-001835-0s7ok4uw	1412	13	zinc	zinc	NN
cord-001835-0s7ok4uw	1412	14	and	and	CC
cord-001835-0s7ok4uw	1412	15	copper	copper	NN
cord-001835-0s7ok4uw	1412	16	,	,	,
cord-001835-0s7ok4uw	1412	17	which	which	WDT
cord-001835-0s7ok4uw	1412	18	are	be	VBP
cord-001835-0s7ok4uw	1412	19	key	key	JJ
cord-001835-0s7ok4uw	1412	20	players	player	NNS
cord-001835-0s7ok4uw	1412	21	in	in	IN
cord-001835-0s7ok4uw	1412	22	brain	brain	NN
cord-001835-0s7ok4uw	1412	23	function	function	NN
cord-001835-0s7ok4uw	1412	24	and	and	CC
cord-001835-0s7ok4uw	1412	25	have	have	VBP
cord-001835-0s7ok4uw	1412	26	altered	alter	VBN
cord-001835-0s7ok4uw	1412	27	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	1412	28	in	in	IN
cord-001835-0s7ok4uw	1412	29	most	most	JJS
cord-001835-0s7ok4uw	1412	30	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	1412	31	conditions	condition	NNS
cord-001835-0s7ok4uw	1412	32	.	.	.
cord-001835-0s7ok4uw	1413	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1413	2	recent	recent	JJ
cord-001835-0s7ok4uw	1413	3	work	work	NN
cord-001835-0s7ok4uw	1413	4	will	will	MD
cord-001835-0s7ok4uw	1413	5	illustrate	illustrate	VB
cord-001835-0s7ok4uw	1413	6	how	how	WRB
cord-001835-0s7ok4uw	1413	7	this	this	DT
cord-001835-0s7ok4uw	1413	8	allows	allow	VBZ
cord-001835-0s7ok4uw	1413	9	establishing	establish	VBG
cord-001835-0s7ok4uw	1413	10	molecular	molecular	JJ
cord-001835-0s7ok4uw	1413	11	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1413	12	in	in	IN
cord-001835-0s7ok4uw	1413	13	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	1413	14	diseases	disease	NNS
cord-001835-0s7ok4uw	1413	15	[	[	-LRB-
cord-001835-0s7ok4uw	1413	16	2	2	CD
cord-001835-0s7ok4uw	1413	17	]	]	-RRB-
cord-001835-0s7ok4uw	1413	18	[	[	-LRB-
cord-001835-0s7ok4uw	1413	19	3	3	CD
cord-001835-0s7ok4uw	1413	20	]	]	-RRB-
cord-001835-0s7ok4uw	1413	21	[	[	-LRB-
cord-001835-0s7ok4uw	1413	22	4	4	CD
cord-001835-0s7ok4uw	1413	23	]	]	-RRB-
cord-001835-0s7ok4uw	1413	24	[	[	-LRB-
cord-001835-0s7ok4uw	1413	25	5	5	CD
cord-001835-0s7ok4uw	1413	26	]	]	-RRB-
cord-001835-0s7ok4uw	1413	27	[	[	-LRB-
cord-001835-0s7ok4uw	1413	28	6	6	CD
cord-001835-0s7ok4uw	1413	29	]	]	-RRB-
cord-001835-0s7ok4uw	1413	30	.	.	.
cord-001835-0s7ok4uw	1414	1	In	in	IN
cord-001835-0s7ok4uw	1414	2	the	the	DT
cord-001835-0s7ok4uw	1414	3	pursuit	pursuit	NN
cord-001835-0s7ok4uw	1414	4	of	of	IN
cord-001835-0s7ok4uw	1414	5	this	this	DT
cord-001835-0s7ok4uw	1414	6	goal	goal	NN
cord-001835-0s7ok4uw	1414	7	,	,	,
cord-001835-0s7ok4uw	1414	8	in	in	IN
cord-001835-0s7ok4uw	1414	9	the	the	DT
cord-001835-0s7ok4uw	1414	10	last	last	JJ
cord-001835-0s7ok4uw	1414	11	years	year	NNS
cord-001835-0s7ok4uw	1414	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	1414	13	have	have	VBP
cord-001835-0s7ok4uw	1414	14	been	be	VBN
cord-001835-0s7ok4uw	1414	15	investigating	investigate	VBG
cord-001835-0s7ok4uw	1414	16	superoxide	superoxide	NN
cord-001835-0s7ok4uw	1414	17	dismutase	dismutase	NN
cord-001835-0s7ok4uw	1414	18	1	1	CD
cord-001835-0s7ok4uw	1414	19	(	(	-LRB-
cord-001835-0s7ok4uw	1414	20	SOD1	SOD1	NNP
cord-001835-0s7ok4uw	1414	21	)	)	-RRB-
cord-001835-0s7ok4uw	1414	22	,	,	,
cord-001835-0s7ok4uw	1414	23	a	a	DT
cord-001835-0s7ok4uw	1414	24	Cu	Cu	NNP
cord-001835-0s7ok4uw	1414	25	/	/	SYM
cord-001835-0s7ok4uw	1414	26	Zn	Zn	NNP
cord-001835-0s7ok4uw	1414	27	metalloenzyme	metalloenzyme	NNS
cord-001835-0s7ok4uw	1414	28	that	that	IN
cord-001835-0s7ok4uw	1414	29	aggregates	aggregate	VBZ
cord-001835-0s7ok4uw	1414	30	in	in	IN
cord-001835-0s7ok4uw	1414	31	the	the	DT
cord-001835-0s7ok4uw	1414	32	fatal	fatal	JJ
cord-001835-0s7ok4uw	1414	33	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	1414	34	disorder	disorder	NN
cord-001835-0s7ok4uw	1414	35	ALS	als	NN
cord-001835-0s7ok4uw	1414	36	,	,	,
cord-001835-0s7ok4uw	1414	37	as	as	IN
cord-001835-0s7ok4uw	1414	38	a	a	DT
cord-001835-0s7ok4uw	1414	39	model	model	NN
cord-001835-0s7ok4uw	1414	40	.	.	.
cord-001835-0s7ok4uw	1415	1	In	in	IN
cord-001835-0s7ok4uw	1415	2	SOD1-ALS	SOD1-ALS	NNP
cord-001835-0s7ok4uw	1415	3	cases	case	NNS
cord-001835-0s7ok4uw	1415	4	,	,	,
cord-001835-0s7ok4uw	1415	5	this	this	DT
cord-001835-0s7ok4uw	1415	6	ubiquitous	ubiquitous	JJ
cord-001835-0s7ok4uw	1415	7	protein	protein	NN
cord-001835-0s7ok4uw	1415	8	selectively	selectively	RB
cord-001835-0s7ok4uw	1415	9	aggregates	aggregate	VBZ
cord-001835-0s7ok4uw	1415	10	in	in	IN
cord-001835-0s7ok4uw	1415	11	motor	motor	NN
cord-001835-0s7ok4uw	1415	12	neurons	neuron	NNS
cord-001835-0s7ok4uw	1415	13	,	,	,
cord-001835-0s7ok4uw	1415	14	implicating	implicate	VBG
cord-001835-0s7ok4uw	1415	15	a	a	DT
cord-001835-0s7ok4uw	1415	16	local	local	JJ
cord-001835-0s7ok4uw	1415	17	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	1415	18	factor	factor	NN
cord-001835-0s7ok4uw	1415	19	in	in	IN
cord-001835-0s7ok4uw	1415	20	the	the	DT
cord-001835-0s7ok4uw	1415	21	process	process	NN
cord-001835-0s7ok4uw	1415	22	:	:	:
cord-001835-0s7ok4uw	1415	23	interestingly	interestingly	RB
cord-001835-0s7ok4uw	1415	24	,	,	,
cord-001835-0s7ok4uw	1415	25	Zn21	zn21	XX
cord-001835-0s7ok4uw	1416	1	and	and	CC
cord-001835-0s7ok4uw	1416	2	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	1416	3	levels	level	NNS
cord-001835-0s7ok4uw	1416	4	are	be	VBP
cord-001835-0s7ok4uw	1416	5	upregulated	upregulate	VBN
cord-001835-0s7ok4uw	1416	6	in	in	IN
cord-001835-0s7ok4uw	1416	7	the	the	DT
cord-001835-0s7ok4uw	1416	8	spinal	spinal	JJ
cord-001835-0s7ok4uw	1416	9	and	and	CC
cord-001835-0s7ok4uw	1416	10	brain	brain	NN
cord-001835-0s7ok4uw	1416	11	stem	stem	NN
cord-001835-0s7ok4uw	1416	12	motor	motor	NN
cord-001835-0s7ok4uw	1416	13	neurons	neuron	NNS
cord-001835-0s7ok4uw	1416	14	of	of	IN
cord-001835-0s7ok4uw	1416	15	ALS	als	NN
cord-001835-0s7ok4uw	1416	16	patients	patient	NNS
cord-001835-0s7ok4uw	1416	17	,	,	,
cord-001835-0s7ok4uw	1416	18	and	and	CC
cord-001835-0s7ok4uw	1416	19	increased	increase	VBN
cord-001835-0s7ok4uw	1416	20	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	1416	21	triggers	trigger	VBZ
cord-001835-0s7ok4uw	1416	22	multiple	multiple	JJ
cord-001835-0s7ok4uw	1416	23	pathophysiological	pathophysiological	JJ
cord-001835-0s7ok4uw	1416	24	processes	process	NNS
cord-001835-0s7ok4uw	1416	25	which	which	WDT
cord-001835-0s7ok4uw	1416	26	include	include	VBP
cord-001835-0s7ok4uw	1416	27	direct	direct	JJ
cord-001835-0s7ok4uw	1416	28	effects	effect	NNS
cord-001835-0s7ok4uw	1416	29	on	on	IN
cord-001835-0s7ok4uw	1416	30	the	the	DT
cord-001835-0s7ok4uw	1416	31	SOD1	SOD1	NNP
cord-001835-0s7ok4uw	1416	32	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1416	33	cascade	cascade	NN
cord-001835-0s7ok4uw	1416	34	[	[	-LRB-
cord-001835-0s7ok4uw	1416	35	2	2	CD
cord-001835-0s7ok4uw	1416	36	,	,	,
cord-001835-0s7ok4uw	1416	37	3	3	CD
cord-001835-0s7ok4uw	1416	38	]	]	-RRB-
cord-001835-0s7ok4uw	1416	39	.	.	.
cord-001835-0s7ok4uw	1417	1	Recently	recently	RB
cord-001835-0s7ok4uw	1417	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	1417	3	established	establish	VBD
cord-001835-0s7ok4uw	1417	4	that	that	IN
cord-001835-0s7ok4uw	1417	5	calcium	calcium	NN
cord-001835-0s7ok4uw	1417	6	ions	ion	NNS
cord-001835-0s7ok4uw	1417	7	promote	promote	VBP
cord-001835-0s7ok4uw	1417	8	SOD1	SOD1	NNP
cord-001835-0s7ok4uw	1417	9	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1417	10	into	into	IN
cord-001835-0s7ok4uw	1417	11	non	non	JJ
cord-001835-0s7ok4uw	1417	12	-	-	JJ
cord-001835-0s7ok4uw	1417	13	fibrillar	fibrillar	JJ
cord-001835-0s7ok4uw	1417	14	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1417	15	,	,	,
cord-001835-0s7ok4uw	1417	16	suggesting	suggest	VBG
cord-001835-0s7ok4uw	1417	17	a	a	DT
cord-001835-0s7ok4uw	1417	18	link	link	NN
cord-001835-0s7ok4uw	1417	19	to	to	IN
cord-001835-0s7ok4uw	1417	20	toxic	toxic	JJ
cord-001835-0s7ok4uw	1417	21	effects	effect	NNS
cord-001835-0s7ok4uw	1417	22	of	of	IN
cord-001835-0s7ok4uw	1417	23	calcium	calcium	NN
cord-001835-0s7ok4uw	1417	24	overload	overload	NN
cord-001835-0s7ok4uw	1417	25	in	in	IN
cord-001835-0s7ok4uw	1417	26	ALS	ALS	NNP
cord-001835-0s7ok4uw	1417	27	[	[	-LRB-
cord-001835-0s7ok4uw	1417	28	4	4	CD
cord-001835-0s7ok4uw	1417	29	]	]	-RRB-
cord-001835-0s7ok4uw	1417	30	.	.	.
cord-001835-0s7ok4uw	1418	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1418	2	showed	show	VBD
cord-001835-0s7ok4uw	1418	3	that	that	IN
cord-001835-0s7ok4uw	1418	4	under	under	IN
cord-001835-0s7ok4uw	1418	5	physiological	physiological	JJ
cord-001835-0s7ok4uw	1418	6	conditions	condition	NNS
cord-001835-0s7ok4uw	1418	7	,	,	,
cord-001835-0s7ok4uw	1418	8	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	1418	9	induces	induce	VBZ
cord-001835-0s7ok4uw	1418	10	conformational	conformational	JJ
cord-001835-0s7ok4uw	1418	11	changes	change	NNS
cord-001835-0s7ok4uw	1418	12	on	on	IN
cord-001835-0s7ok4uw	1418	13	SOD1	SOD1	NNP
cord-001835-0s7ok4uw	1418	14	that	that	WDT
cord-001835-0s7ok4uw	1418	15	increase	increase	VBP
cord-001835-0s7ok4uw	1418	16	SOD1	SOD1	NNP
cord-001835-0s7ok4uw	1418	17	b	b	NN
cord-001835-0s7ok4uw	1418	18	-	-	HYPH
cord-001835-0s7ok4uw	1418	19	sheet	sheet	NN
cord-001835-0s7ok4uw	1418	20	content	content	NN
cord-001835-0s7ok4uw	1418	21	and	and	CC
cord-001835-0s7ok4uw	1418	22	decrease	decrease	VB
cord-001835-0s7ok4uw	1418	23	SOD1	SOD1	NNP
cord-001835-0s7ok4uw	1419	1	critical	critical	JJ
cord-001835-0s7ok4uw	1419	2	concentration	concentration	NN
cord-001835-0s7ok4uw	1419	3	and	and	CC
cord-001835-0s7ok4uw	1419	4	nucleation	nucleation	NN
cord-001835-0s7ok4uw	1419	5	time	time	NN
cord-001835-0s7ok4uw	1419	6	during	during	IN
cord-001835-0s7ok4uw	1419	7	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1419	8	kinetics	kinetics	NNP
cord-001835-0s7ok4uw	1419	9	.	.	.
cord-001835-0s7ok4uw	1420	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1420	2	also	also	RB
cord-001835-0s7ok4uw	1420	3	observed	observe	VBD
cord-001835-0s7ok4uw	1420	4	that	that	IN
cord-001835-0s7ok4uw	1420	5	calcium	calcium	NN
cord-001835-0s7ok4uw	1420	6	diverts	divert	VBZ
cord-001835-0s7ok4uw	1420	7	SOD1	SOD1	NNP
cord-001835-0s7ok4uw	1420	8	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1420	9	from	from	IN
cord-001835-0s7ok4uw	1420	10	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1420	11	towards	towards	IN
cord-001835-0s7ok4uw	1420	12	amorphous	amorphous	JJ
cord-001835-0s7ok4uw	1420	13	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	1420	14	.	.	.
cord-001835-0s7ok4uw	1421	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	1421	2	,	,	,
cord-001835-0s7ok4uw	1421	3	the	the	DT
cord-001835-0s7ok4uw	1421	4	same	same	JJ
cord-001835-0s7ok4uw	1421	5	heterogeneity	heterogeneity	NN
cord-001835-0s7ok4uw	1421	6	of	of	IN
cord-001835-0s7ok4uw	1421	7	conformations	conformation	NNS
cord-001835-0s7ok4uw	1421	8	is	be	VBZ
cord-001835-0s7ok4uw	1421	9	found	find	VBN
cord-001835-0s7ok4uw	1421	10	in	in	IN
cord-001835-0s7ok4uw	1421	11	ALS	als	NN
cord-001835-0s7ok4uw	1421	12	-	-	HYPH
cord-001835-0s7ok4uw	1421	13	derived	derive	VBN
cord-001835-0s7ok4uw	1421	14	protein	protein	NN
cord-001835-0s7ok4uw	1421	15	inclusions	inclusion	NNS
cord-001835-0s7ok4uw	1421	16	.	.	.
cord-001835-0s7ok4uw	1422	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1422	2	thus	thus	RB
cord-001835-0s7ok4uw	1422	3	hypothesized	hypothesize	VBD
cord-001835-0s7ok4uw	1422	4	that	that	IN
cord-001835-0s7ok4uw	1422	5	transient	transient	JJ
cord-001835-0s7ok4uw	1422	6	variations	variation	NNS
cord-001835-0s7ok4uw	1422	7	and	and	CC
cord-001835-0s7ok4uw	1422	8	dysregulation	dysregulation	NN
cord-001835-0s7ok4uw	1422	9	of	of	IN
cord-001835-0s7ok4uw	1422	10	cellular	cellular	JJ
cord-001835-0s7ok4uw	1422	11	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	1422	12	and	and	CC
cord-001835-0s7ok4uw	1422	13	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	1422	14	levels	level	NNS
cord-001835-0s7ok4uw	1422	15	contribute	contribute	VBP
cord-001835-0s7ok4uw	1422	16	to	to	IN
cord-001835-0s7ok4uw	1422	17	the	the	DT
cord-001835-0s7ok4uw	1422	18	formation	formation	NN
cord-001835-0s7ok4uw	1422	19	of	of	IN
cord-001835-0s7ok4uw	1422	20	SOD1	SOD1	NNP
cord-001835-0s7ok4uw	1422	21	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	1422	22	in	in	IN
cord-001835-0s7ok4uw	1422	23	ALS	als	NN
cord-001835-0s7ok4uw	1422	24	patients	patient	NNS
cord-001835-0s7ok4uw	1422	25	[	[	-LRB-
cord-001835-0s7ok4uw	1422	26	4	4	CD
cord-001835-0s7ok4uw	1422	27	,	,	,
cord-001835-0s7ok4uw	1422	28	5	5	CD
cord-001835-0s7ok4uw	1422	29	]	]	-RRB-
cord-001835-0s7ok4uw	1422	30	.	.	.
cord-001835-0s7ok4uw	1423	1	In	in	IN
cord-001835-0s7ok4uw	1423	2	a	a	DT
cord-001835-0s7ok4uw	1423	3	follow	follow	NN
cord-001835-0s7ok4uw	1423	4	up	up	RP
cord-001835-0s7ok4uw	1423	5	study	study	NN
cord-001835-0s7ok4uw	1423	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	1423	7	combined	combine	VBD
cord-001835-0s7ok4uw	1423	8	experimental	experimental	JJ
cord-001835-0s7ok4uw	1423	9	and	and	CC
cord-001835-0s7ok4uw	1423	10	computational	computational	JJ
cord-001835-0s7ok4uw	1423	11	approaches	approach	NNS
cord-001835-0s7ok4uw	1423	12	to	to	TO
cord-001835-0s7ok4uw	1423	13	show	show	VB
cord-001835-0s7ok4uw	1423	14	that	that	IN
cord-001835-0s7ok4uw	1423	15	the	the	DT
cord-001835-0s7ok4uw	1423	16	most	most	RBS
cord-001835-0s7ok4uw	1423	17	frequent	frequent	JJ
cord-001835-0s7ok4uw	1423	18	ligands	ligand	NNS
cord-001835-0s7ok4uw	1423	19	for	for	IN
cord-001835-0s7ok4uw	1423	20	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	1423	21	are	be	VBP
cord-001835-0s7ok4uw	1423	22	negatively	negatively	RB
cord-001835-0s7ok4uw	1423	23	-	-	HYPH
cord-001835-0s7ok4uw	1423	24	charged	charge	VBN
cord-001835-0s7ok4uw	1423	25	gatekeeper	gatekeeper	NN
cord-001835-0s7ok4uw	1423	26	residues	residue	NNS
cord-001835-0s7ok4uw	1423	27	located	locate	VBN
cord-001835-0s7ok4uw	1423	28	in	in	IN
cord-001835-0s7ok4uw	1423	29	boundary	boundary	JJ
cord-001835-0s7ok4uw	1423	30	positions	position	NNS
cord-001835-0s7ok4uw	1423	31	with	with	IN
cord-001835-0s7ok4uw	1423	32	respect	respect	NN
cord-001835-0s7ok4uw	1423	33	to	to	IN
cord-001835-0s7ok4uw	1423	34	segments	segment	NNS
cord-001835-0s7ok4uw	1423	35	highly	highly	RB
cord-001835-0s7ok4uw	1423	36	prone	prone	JJ
cord-001835-0s7ok4uw	1423	37	to	to	IN
cord-001835-0s7ok4uw	1423	38	edge	edge	VB
cord-001835-0s7ok4uw	1423	39	-	-	HYPH
cord-001835-0s7ok4uw	1423	40	to	to	IN
cord-001835-0s7ok4uw	1423	41	-	-	HYPH
cord-001835-0s7ok4uw	1423	42	edge	edge	NN
cord-001835-0s7ok4uw	1423	43	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1423	44	.	.	.
cord-001835-0s7ok4uw	1424	1	Calcium	calcium	NN
cord-001835-0s7ok4uw	1424	2	interactions	interaction	NNS
cord-001835-0s7ok4uw	1424	3	thus	thus	RB
cord-001835-0s7ok4uw	1424	4	diminish	diminish	VBP
cord-001835-0s7ok4uw	1424	5	gatekeeping	gatekeepe	VBG
cord-001835-0s7ok4uw	1424	6	roles	role	NNS
cord-001835-0s7ok4uw	1424	7	by	by	IN
cord-001835-0s7ok4uw	1424	8	shielding	shield	VBG
cord-001835-0s7ok4uw	1424	9	repulsive	repulsive	JJ
cord-001835-0s7ok4uw	1424	10	interactions	interaction	NNS
cord-001835-0s7ok4uw	1424	11	via	via	IN
cord-001835-0s7ok4uw	1424	12	stacking	stack	VBG
cord-001835-0s7ok4uw	1424	13	between	between	IN
cord-001835-0s7ok4uw	1424	14	aggregating	aggregate	VBG
cord-001835-0s7ok4uw	1424	15	b	b	NN
cord-001835-0s7ok4uw	1424	16	-	-	HYPH
cord-001835-0s7ok4uw	1424	17	sheets	sheet	NNS
cord-001835-0s7ok4uw	1424	18	,	,	,
cord-001835-0s7ok4uw	1424	19	partly	partly	RB
cord-001835-0s7ok4uw	1424	20	blocking	block	VBG
cord-001835-0s7ok4uw	1424	21	fibril	fibril	NN
cord-001835-0s7ok4uw	1424	22	formation	formation	NN
cord-001835-0s7ok4uw	1424	23	and	and	CC
cord-001835-0s7ok4uw	1424	24	promoting	promote	VBG
cord-001835-0s7ok4uw	1424	25	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	1424	26	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	1424	27	such	such	JJ
cord-001835-0s7ok4uw	1424	28	as	as	IN
cord-001835-0s7ok4uw	1424	29	those	those	DT
cord-001835-0s7ok4uw	1424	30	found	find	VBN
cord-001835-0s7ok4uw	1424	31	in	in	IN
cord-001835-0s7ok4uw	1424	32	ALS	als	NN
cord-001835-0s7ok4uw	1424	33	inclusions	inclusion	NNS
cord-001835-0s7ok4uw	1424	34	.	.	.
cord-001835-0s7ok4uw	1425	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	1425	2	,	,	,
cord-001835-0s7ok4uw	1425	3	many	many	JJ
cord-001835-0s7ok4uw	1425	4	fALS	fals	NN
cord-001835-0s7ok4uw	1425	5	mutations	mutation	NNS
cord-001835-0s7ok4uw	1425	6	occur	occur	VBP
cord-001835-0s7ok4uw	1425	7	at	at	IN
cord-001835-0s7ok4uw	1425	8	these	these	DT
cord-001835-0s7ok4uw	1425	9	positions	position	NNS
cord-001835-0s7ok4uw	1425	10	,	,	,
cord-001835-0s7ok4uw	1425	11	disclosing	disclose	VBG
cord-001835-0s7ok4uw	1425	12	how	how	WRB
cord-001835-0s7ok4uw	1425	13	Ca21	Ca21	.
cord-001835-0s7ok4uw	1426	1	interactions	interaction	NNS
cord-001835-0s7ok4uw	1426	2	recreate	recreate	VBP
cord-001835-0s7ok4uw	1426	3	effects	effect	NNS
cord-001835-0s7ok4uw	1426	4	similar	similar	JJ
cord-001835-0s7ok4uw	1426	5	to	to	IN
cord-001835-0s7ok4uw	1426	6	those	those	DT
cord-001835-0s7ok4uw	1426	7	of	of	IN
cord-001835-0s7ok4uw	1426	8	genetic	genetic	JJ
cord-001835-0s7ok4uw	1426	9	defects	defect	NNS
cord-001835-0s7ok4uw	1426	10	,	,	,
cord-001835-0s7ok4uw	1426	11	a	a	DT
cord-001835-0s7ok4uw	1426	12	finding	finding	NN
cord-001835-0s7ok4uw	1426	13	with	with	IN
cord-001835-0s7ok4uw	1426	14	relevance	relevance	NN
cord-001835-0s7ok4uw	1426	15	to	to	TO
cord-001835-0s7ok4uw	1426	16	understand	understand	VB
cord-001835-0s7ok4uw	1426	17	sporadic	sporadic	JJ
cord-001835-0s7ok4uw	1426	18	ALS	als	NN
cord-001835-0s7ok4uw	1426	19	pathomechanisms	pathomechanism	NNS
cord-001835-0s7ok4uw	1426	20	[	[	-LRB-
cord-001835-0s7ok4uw	1426	21	6	6	CD
cord-001835-0s7ok4uw	1426	22	]	]	-RRB-
cord-001835-0s7ok4uw	1426	23	.	.	.
cord-001835-0s7ok4uw	1427	1	The	the	DT
cord-001835-0s7ok4uw	1427	2	amino	amino	NN
cord-001835-0s7ok4uw	1427	3	acid	acid	NN
cord-001835-0s7ok4uw	1427	4	proline	proline	NN
cord-001835-0s7ok4uw	1427	5	is	be	VBZ
cord-001835-0s7ok4uw	1427	6	well	well	RB
cord-001835-0s7ok4uw	1427	7	-	-	HYPH
cord-001835-0s7ok4uw	1427	8	known	know	VBN
cord-001835-0s7ok4uw	1427	9	by	by	IN
cord-001835-0s7ok4uw	1427	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1427	11	disorder	disorder	NN
cord-001835-0s7ok4uw	1427	12	promoting	promote	VBG
cord-001835-0s7ok4uw	1427	13	and	and	CC
cord-001835-0s7ok4uw	1427	14	helix	helix	NN
cord-001835-0s7ok4uw	1427	15	breaking	breaking	NN
cord-001835-0s7ok4uw	1427	16	properties	property	NNS
cord-001835-0s7ok4uw	1427	17	.	.	.
cord-001835-0s7ok4uw	1428	1	Prolines	proline	NNS
cord-001835-0s7ok4uw	1428	2	can	can	MD
cord-001835-0s7ok4uw	1428	3	be	be	VB
cord-001835-0s7ok4uw	1428	4	accommodated	accommodate	VBN
cord-001835-0s7ok4uw	1428	5	within	within	IN
cord-001835-0s7ok4uw	1428	6	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	1428	7	(	(	-LRB-
cord-001835-0s7ok4uw	1428	8	TM	TM	NNP
cord-001835-0s7ok4uw	1428	9	)	)	-RRB-
cord-001835-0s7ok4uw	1428	10	alpha	alpha	NN
cord-001835-0s7ok4uw	1428	11	-	-	HYPH
cord-001835-0s7ok4uw	1428	12	helices	helix	NNS
cord-001835-0s7ok4uw	1428	13	and	and	CC
cord-001835-0s7ok4uw	1428	14	participate	participate	VB
cord-001835-0s7ok4uw	1428	15	in	in	IN
cord-001835-0s7ok4uw	1428	16	important	important	JJ
cord-001835-0s7ok4uw	1428	17	biological	biological	JJ
cord-001835-0s7ok4uw	1428	18	tasks	task	NNS
cord-001835-0s7ok4uw	1428	19	like	like	IN
cord-001835-0s7ok4uw	1428	20	signal	signal	NN
cord-001835-0s7ok4uw	1428	21	transduction	transduction	NN
cord-001835-0s7ok4uw	1428	22	,	,	,
cord-001835-0s7ok4uw	1428	23	ligand	ligand	NN
cord-001835-0s7ok4uw	1428	24	binding	binding	NN
cord-001835-0s7ok4uw	1428	25	and	and	CC
cord-001835-0s7ok4uw	1428	26	helix	helix	NN
cord-001835-0s7ok4uw	1428	27	-	-	HYPH
cord-001835-0s7ok4uw	1428	28	helix	helix	NN
cord-001835-0s7ok4uw	1428	29	packing	packing	NN
cord-001835-0s7ok4uw	1428	30	.	.	.
cord-001835-0s7ok4uw	1429	1	X	x	NN
cord-001835-0s7ok4uw	1429	2	-	-	NN
cord-001835-0s7ok4uw	1429	3	ray	ray	NN
cord-001835-0s7ok4uw	1429	4	crystallography	crystallography	NN
cord-001835-0s7ok4uw	1429	5	and	and	CC
cord-001835-0s7ok4uw	1429	6	NMR	NMR	NNP
cord-001835-0s7ok4uw	1429	7	indicate	indicate	VBP
cord-001835-0s7ok4uw	1429	8	that	that	IN
cord-001835-0s7ok4uw	1429	9	proline	proline	NN
cord-001835-0s7ok4uw	1429	10	residues	residue	NNS
cord-001835-0s7ok4uw	1429	11	in	in	IN
cord-001835-0s7ok4uw	1429	12	membrane	membrane	NN
cord-001835-0s7ok4uw	1429	13	proteins	protein	NNS
cord-001835-0s7ok4uw	1429	14	induce	induce	VBP
cord-001835-0s7ok4uw	1429	15	distortions	distortion	NNS
cord-001835-0s7ok4uw	1429	16	of	of	IN
cord-001835-0s7ok4uw	1429	17	the	the	DT
cord-001835-0s7ok4uw	1429	18	helix	helix	NN
cord-001835-0s7ok4uw	1429	19	geometry	geometry	NN
cord-001835-0s7ok4uw	1429	20	to	to	IN
cord-001835-0s7ok4uw	1429	21	different	different	JJ
cord-001835-0s7ok4uw	1429	22	extents	extent	NNS
cord-001835-0s7ok4uw	1429	23	ranging	range	VBG
cord-001835-0s7ok4uw	1429	24	from	from	IN
cord-001835-0s7ok4uw	1429	25	small	small	JJ
cord-001835-0s7ok4uw	1429	26	bends	bend	NNS
cord-001835-0s7ok4uw	1429	27	to	to	IN
cord-001835-0s7ok4uw	1429	28	severe	severe	JJ
cord-001835-0s7ok4uw	1429	29	kinks	kink	NNS
cord-001835-0s7ok4uw	1429	30	.	.	.
cord-001835-0s7ok4uw	1430	1	However	however	RB
cord-001835-0s7ok4uw	1430	2	,	,	,
cord-001835-0s7ok4uw	1430	3	such	such	JJ
cord-001835-0s7ok4uw	1430	4	studies	study	NNS
cord-001835-0s7ok4uw	1430	5	provide	provide	VBP
cord-001835-0s7ok4uw	1430	6	essentially	essentially	RB
cord-001835-0s7ok4uw	1430	7	a	a	DT
cord-001835-0s7ok4uw	1430	8	static	static	JJ
cord-001835-0s7ok4uw	1430	9	snapshot	snapshot	NN
cord-001835-0s7ok4uw	1430	10	of	of	IN
cord-001835-0s7ok4uw	1430	11	membrane	membrane	NN
cord-001835-0s7ok4uw	1430	12	-	-	HYPH
cord-001835-0s7ok4uw	1430	13	embedded	embed	VBN
cord-001835-0s7ok4uw	1430	14	helices	helix	NNS
cord-001835-0s7ok4uw	1430	15	.	.	.
cord-001835-0s7ok4uw	1431	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	1431	2	,	,	,
cord-001835-0s7ok4uw	1431	3	the	the	DT
cord-001835-0s7ok4uw	1431	4	link	link	NN
cord-001835-0s7ok4uw	1431	5	between	between	IN
cord-001835-0s7ok4uw	1431	6	proline	proline	NN
cord-001835-0s7ok4uw	1431	7	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1431	8	and	and	CC
cord-001835-0s7ok4uw	1431	9	function	function	NN
cord-001835-0s7ok4uw	1431	10	is	be	VBZ
cord-001835-0s7ok4uw	1431	11	not	not	RB
cord-001835-0s7ok4uw	1431	12	completely	completely	RB
cord-001835-0s7ok4uw	1431	13	understood	understand	VBN
cord-001835-0s7ok4uw	1431	14	.	.	.
cord-001835-0s7ok4uw	1432	1	In	in	IN
cord-001835-0s7ok4uw	1432	2	this	this	DT
cord-001835-0s7ok4uw	1432	3	work	work	NN
cord-001835-0s7ok4uw	1432	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	1432	5	have	have	VBP
cord-001835-0s7ok4uw	1432	6	used	use	VBN
cord-001835-0s7ok4uw	1432	7	singlemolecule	singlemolecule	JJ
cord-001835-0s7ok4uw	1432	8	F€	F€	NNP
cord-001835-0s7ok4uw	1432	9	orster	orster	NN
cord-001835-0s7ok4uw	1432	10	resonance	resonance	NN
cord-001835-0s7ok4uw	1432	11	energy	energy	NN
cord-001835-0s7ok4uw	1432	12	transfer	transfer	NN
cord-001835-0s7ok4uw	1432	13	(	(	-LRB-
cord-001835-0s7ok4uw	1432	14	smFRET	smfret	NN
cord-001835-0s7ok4uw	1432	15	)	)	-RRB-
cord-001835-0s7ok4uw	1432	16	and	and	CC
cord-001835-0s7ok4uw	1432	17	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1432	18	correlation	correlation	NN
cord-001835-0s7ok4uw	1432	19	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1432	20	(	(	-LRB-
cord-001835-0s7ok4uw	1432	21	FCS	FCS	NNP
cord-001835-0s7ok4uw	1432	22	)	)	-RRB-
cord-001835-0s7ok4uw	1432	23	to	to	TO
cord-001835-0s7ok4uw	1432	24	probe	probe	VB
cord-001835-0s7ok4uw	1432	25	the	the	DT
cord-001835-0s7ok4uw	1432	26	structure	structure	NN
cord-001835-0s7ok4uw	1432	27	and	and	CC
cord-001835-0s7ok4uw	1432	28	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1432	29	of	of	IN
cord-001835-0s7ok4uw	1432	30	the	the	DT
cord-001835-0s7ok4uw	1432	31	TM	TM	NNP
cord-001835-0s7ok4uw	1432	32	domain	domain	NN
cord-001835-0s7ok4uw	1432	33	of	of	IN
cord-001835-0s7ok4uw	1432	34	human	human	JJ
cord-001835-0s7ok4uw	1432	35	glycophorin	glycophorin	NN
cord-001835-0s7ok4uw	1432	36	A	A	NNP
cord-001835-0s7ok4uw	1432	37	(	(	-LRB-
cord-001835-0s7ok4uw	1432	38	GpA	GpA	NNP
cord-001835-0s7ok4uw	1432	39	)	)	-RRB-
cord-001835-0s7ok4uw	1432	40	,	,	,
cord-001835-0s7ok4uw	1432	41	a	a	DT
cord-001835-0s7ok4uw	1432	42	widely	widely	RB
cord-001835-0s7ok4uw	1432	43	used	use	VBN
cord-001835-0s7ok4uw	1432	44	model	model	NN
cord-001835-0s7ok4uw	1432	45	membrane	membrane	NN
cord-001835-0s7ok4uw	1432	46	protein	protein	NN
cord-001835-0s7ok4uw	1432	47	for	for	IN
cord-001835-0s7ok4uw	1432	48	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	1432	49	studies	study	NNS
cord-001835-0s7ok4uw	1432	50	.	.	.
cord-001835-0s7ok4uw	1433	1	A	a	DT
cord-001835-0s7ok4uw	1433	2	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	1433	3	dye	dye	NN
cord-001835-0s7ok4uw	1433	4	pair	pair	NN
cord-001835-0s7ok4uw	1433	5	has	have	VBZ
cord-001835-0s7ok4uw	1433	6	been	be	VBN
cord-001835-0s7ok4uw	1433	7	attached	attach	VBN
cord-001835-0s7ok4uw	1433	8	to	to	IN
cord-001835-0s7ok4uw	1433	9	both	both	DT
cord-001835-0s7ok4uw	1433	10	ends	end	NNS
cord-001835-0s7ok4uw	1433	11	of	of	IN
cord-001835-0s7ok4uw	1433	12	the	the	DT
cord-001835-0s7ok4uw	1433	13	membrane	membrane	NN
cord-001835-0s7ok4uw	1433	14	-	-	HYPH
cord-001835-0s7ok4uw	1433	15	spanning	span	VBG
cord-001835-0s7ok4uw	1433	16	region	region	NN
cord-001835-0s7ok4uw	1433	17	of	of	IN
cord-001835-0s7ok4uw	1433	18	GpA	GpA	NNP
cord-001835-0s7ok4uw	1433	19	,	,	,
cord-001835-0s7ok4uw	1433	20	which	which	WDT
cord-001835-0s7ok4uw	1433	21	allowed	allow	VBD
cord-001835-0s7ok4uw	1433	22	monitoring	monitor	VBG
cord-001835-0s7ok4uw	1433	23	the	the	DT
cord-001835-0s7ok4uw	1433	24	average	average	JJ
cord-001835-0s7ok4uw	1433	25	distance	distance	NN
cord-001835-0s7ok4uw	1433	26	and	and	CC
cord-001835-0s7ok4uw	1433	27	distance	distance	NN
cord-001835-0s7ok4uw	1433	28	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	1433	29	between	between	IN
cord-001835-0s7ok4uw	1433	30	the	the	DT
cord-001835-0s7ok4uw	1433	31	attachment	attachment	NN
cord-001835-0s7ok4uw	1433	32	points	point	NNS
cord-001835-0s7ok4uw	1433	33	.	.	.
cord-001835-0s7ok4uw	1434	1	Site	site	NN
cord-001835-0s7ok4uw	1434	2	-	-	:
cord-001835-0s7ok4uw	1434	3	specifically	specifically	RB
cord-001835-0s7ok4uw	1434	4	double	double	RB
cord-001835-0s7ok4uw	1434	5	-	-	HYPH
cord-001835-0s7ok4uw	1434	6	labeled	label	VBN
cord-001835-0s7ok4uw	1434	7	GpA	gpa	NN
cord-001835-0s7ok4uw	1434	8	has	have	VBZ
cord-001835-0s7ok4uw	1434	9	been	be	VBN
cord-001835-0s7ok4uw	1434	10	reconstituted	reconstitute	VBN
cord-001835-0s7ok4uw	1434	11	into	into	IN
cord-001835-0s7ok4uw	1434	12	two	two	CD
cord-001835-0s7ok4uw	1434	13	membrane	membrane	NN
cord-001835-0s7ok4uw	1434	14	-	-	HYPH
cord-001835-0s7ok4uw	1434	15	mimetic	mimetic	NN
cord-001835-0s7ok4uw	1434	16	systems	system	NNS
cord-001835-0s7ok4uw	1434	17	:	:	:
cord-001835-0s7ok4uw	1434	18	SDS	SDS	NNP
cord-001835-0s7ok4uw	1434	19	micelles	micelle	NNS
cord-001835-0s7ok4uw	1434	20	and	and	CC
cord-001835-0s7ok4uw	1434	21	phospholipid	phospholipid	NN
cord-001835-0s7ok4uw	1434	22	bilayers	bilayer	NNS
cord-001835-0s7ok4uw	1434	23	assembled	assemble	VBN
cord-001835-0s7ok4uw	1434	24	into	into	IN
cord-001835-0s7ok4uw	1434	25	nanodiscs	nanodiscs	NNP
cord-001835-0s7ok4uw	1434	26	.	.	.
cord-001835-0s7ok4uw	1435	1	Using	use	VBG
cord-001835-0s7ok4uw	1435	2	proline	proline	NN
cord-001835-0s7ok4uw	1435	3	-	-	HYPH
cord-001835-0s7ok4uw	1435	4	scanning	scanning	NN
cord-001835-0s7ok4uw	1435	5	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	1435	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	1435	7	have	have	VBP
cord-001835-0s7ok4uw	1435	8	systematically	systematically	RB
cord-001835-0s7ok4uw	1435	9	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	1435	10	the	the	DT
cord-001835-0s7ok4uw	1435	11	impact	impact	NN
cord-001835-0s7ok4uw	1435	12	of	of	IN
cord-001835-0s7ok4uw	1435	13	proline	proline	NN
cord-001835-0s7ok4uw	1435	14	residues	residue	NNS
cord-001835-0s7ok4uw	1435	15	in	in	IN
cord-001835-0s7ok4uw	1435	16	different	different	JJ
cord-001835-0s7ok4uw	1435	17	positions	position	NNS
cord-001835-0s7ok4uw	1435	18	along	along	IN
cord-001835-0s7ok4uw	1435	19	the	the	DT
cord-001835-0s7ok4uw	1435	20	membrane	membrane	NN
cord-001835-0s7ok4uw	1435	21	normal	normal	JJ
cord-001835-0s7ok4uw	1435	22	on	on	IN
cord-001835-0s7ok4uw	1435	23	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	1435	24	helix	helix	NN
cord-001835-0s7ok4uw	1435	25	length	length	NN
cord-001835-0s7ok4uw	1435	26	and	and	CC
cord-001835-0s7ok4uw	1435	27	lateral	lateral	JJ
cord-001835-0s7ok4uw	1435	28	packing	packing	NN
cord-001835-0s7ok4uw	1435	29	.	.	.
cord-001835-0s7ok4uw	1436	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1436	2	,	,	,
cord-001835-0s7ok4uw	1436	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1436	4	have	have	VBP
cord-001835-0s7ok4uw	1436	5	investigated	investigate	VBN
cord-001835-0s7ok4uw	1436	6	the	the	DT
cord-001835-0s7ok4uw	1436	7	distance	distance	NN
cord-001835-0s7ok4uw	1436	8	distribution	distribution	NN
cord-001835-0s7ok4uw	1436	9	in	in	IN
cord-001835-0s7ok4uw	1436	10	TM	TM	NNP
cord-001835-0s7ok4uw	1436	11	helices	helix	NNS
cord-001835-0s7ok4uw	1436	12	containing	contain	VBG
cord-001835-0s7ok4uw	1436	13	native	native	JJ
cord-001835-0s7ok4uw	1436	14	prolines	proline	NNS
cord-001835-0s7ok4uw	1436	15	,	,	,
cord-001835-0s7ok4uw	1436	16	namely	namely	RB
cord-001835-0s7ok4uw	1436	17	the	the	DT
cord-001835-0s7ok4uw	1436	18	insulin	insulin	NN
cord-001835-0s7ok4uw	1436	19	receptor	receptor	NN
cord-001835-0s7ok4uw	1436	20	and	and	CC
cord-001835-0s7ok4uw	1436	21	the	the	DT
cord-001835-0s7ok4uw	1436	22	nesprin	nesprin	NNP
cord-001835-0s7ok4uw	1436	23	protein	protein	NN
cord-001835-0s7ok4uw	1436	24	.	.	.
cord-001835-0s7ok4uw	1437	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1437	2	results	result	NNS
cord-001835-0s7ok4uw	1437	3	shed	shed	VBP
cord-001835-0s7ok4uw	1437	4	light	light	NN
cord-001835-0s7ok4uw	1437	5	into	into	IN
cord-001835-0s7ok4uw	1437	6	the	the	DT
cord-001835-0s7ok4uw	1437	7	relation	relation	NN
cord-001835-0s7ok4uw	1437	8	between	between	IN
cord-001835-0s7ok4uw	1437	9	proline	proline	NN
cord-001835-0s7ok4uw	1437	10	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1437	11	and	and	CC
cord-001835-0s7ok4uw	1437	12	the	the	DT
cord-001835-0s7ok4uw	1437	13	folding	folding	NN
cord-001835-0s7ok4uw	1437	14	and	and	CC
cord-001835-0s7ok4uw	1437	15	function	function	NN
cord-001835-0s7ok4uw	1437	16	of	of	IN
cord-001835-0s7ok4uw	1437	17	TM	TM	NNP
cord-001835-0s7ok4uw	1437	18	helices	helix	NNS
cord-001835-0s7ok4uw	1437	19	.	.	.
cord-001835-0s7ok4uw	1438	1	Thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1438	2	contributions	contribution	NNS
cord-001835-0s7ok4uw	1438	3	of	of	IN
cord-001835-0s7ok4uw	1438	4	specific	specific	JJ
cord-001835-0s7ok4uw	1438	5	mutations	mutation	NNS
cord-001835-0s7ok4uw	1438	6	of	of	IN
cord-001835-0s7ok4uw	1438	7	L30e	L30e	NNS
cord-001835-0s7ok4uw	1438	8	protein	protein	NN
cord-001835-0s7ok4uw	1438	9	in	in	IN
cord-001835-0s7ok4uw	1438	10	the	the	DT
cord-001835-0s7ok4uw	1438	11	RNA	RNA	NNP
cord-001835-0s7ok4uw	1438	12	:	:	:
cord-001835-0s7ok4uw	1438	13	protein	protein	NN
cord-001835-0s7ok4uw	1438	14	interface	interface	NN
cord-001835-0s7ok4uw	1438	15	region	region	NN
cord-001835-0s7ok4uw	1438	16	measured	measure	VBN
cord-001835-0s7ok4uw	1438	17	by	by	IN
cord-001835-0s7ok4uw	1438	18	analytical	analytical	JJ
cord-001835-0s7ok4uw	1438	19	ultracentrifugation	ultracentrifugation	NNP
cord-001835-0s7ok4uw	1438	20	and	and	CC
cord-001835-0s7ok4uw	1438	21	gel	gel	NN
cord-001835-0s7ok4uw	1438	22	shift	shift	NN
cord-001835-0s7ok4uw	1438	23	assay	assay	NN
cord-001835-0s7ok4uw	1438	24	Bashkim	Bashkim	NNP
cord-001835-0s7ok4uw	1438	25	Kokona	Kokona	NNP
cord-001835-0s7ok4uw	1438	26	1,2	1,2	CD
cord-001835-0s7ok4uw	1438	27	,	,	,
cord-001835-0s7ok4uw	1438	28	Sara	Sara	NNP
cord-001835-0s7ok4uw	1438	29	Kim	Kim	NNP
cord-001835-0s7ok4uw	1438	30	1	1	CD
cord-001835-0s7ok4uw	1438	31	,	,	,
cord-001835-0s7ok4uw	1438	32	Margaret	Margaret	NNP
cord-001835-0s7ok4uw	1438	33	Patchin	Patchin	NNP
cord-001835-0s7ok4uw	1438	34	1	1	CD
cord-001835-0s7ok4uw	1438	35	,	,	,
cord-001835-0s7ok4uw	1438	36	Britt	Britt	NNP
cord-001835-0s7ok4uw	1438	37	Benner	Benner	NNP
cord-001835-0s7ok4uw	1438	38	1	1	CD
cord-001835-0s7ok4uw	1439	1	,	,	,
cord-001835-0s7ok4uw	1439	2	Susan	Susan	NNP
cord-001835-0s7ok4uw	1439	3	White	White	NNP
cord-001835-0s7ok4uw	1439	4	1	1	CD
cord-001835-0s7ok4uw	1439	5	1	1	CD
cord-001835-0s7ok4uw	1440	1	In	in	IN
cord-001835-0s7ok4uw	1440	2	Saccharomyces	Saccharomyces	NNP
cord-001835-0s7ok4uw	1440	3	cerevisiae	cerevisiae	NNS
cord-001835-0s7ok4uw	1440	4	,	,	,
cord-001835-0s7ok4uw	1440	5	ribosomal	ribosomal	JJ
cord-001835-0s7ok4uw	1440	6	protein	protein	NN
cord-001835-0s7ok4uw	1440	7	L30e	l30e	WDT
cord-001835-0s7ok4uw	1440	8	acts	act	VBZ
cord-001835-0s7ok4uw	1440	9	as	as	IN
cord-001835-0s7ok4uw	1440	10	an	an	DT
cord-001835-0s7ok4uw	1440	11	autoregulator	autoregulator	NN
cord-001835-0s7ok4uw	1440	12	by	by	IN
cord-001835-0s7ok4uw	1440	13	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	1440	14	the	the	DT
cord-001835-0s7ok4uw	1440	15	splicing	splicing	NN
cord-001835-0s7ok4uw	1440	16	of	of	IN
cord-001835-0s7ok4uw	1440	17	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1440	18	pre	pre	JJ
cord-001835-0s7ok4uw	1440	19	-	-	NN
cord-001835-0s7ok4uw	1440	20	mRNA	mrna	NN
cord-001835-0s7ok4uw	1440	21	and	and	CC
cord-001835-0s7ok4uw	1440	22	translation	translation	NN
cord-001835-0s7ok4uw	1440	23	of	of	IN
cord-001835-0s7ok4uw	1440	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1440	25	mRNA	mrna	NN
cord-001835-0s7ok4uw	1440	26	.	.	.
cord-001835-0s7ok4uw	1441	1	The	the	DT
cord-001835-0s7ok4uw	1441	2	L30e	L30e	NNP
cord-001835-0s7ok4uw	1441	3	protein	protein	NN
cord-001835-0s7ok4uw	1441	4	-	-	HYPH
cord-001835-0s7ok4uw	1441	5	RNA	RNA	NNP
cord-001835-0s7ok4uw	1441	6	binding	binding	NN
cord-001835-0s7ok4uw	1441	7	site	site	NN
cord-001835-0s7ok4uw	1441	8	has	have	VBZ
cord-001835-0s7ok4uw	1441	9	been	be	VBN
cord-001835-0s7ok4uw	1441	10	previously	previously	RB
cord-001835-0s7ok4uw	1441	11	studied	study	VBN
cord-001835-0s7ok4uw	1441	12	,	,	,
cord-001835-0s7ok4uw	1441	13	revealing	reveal	VBG
cord-001835-0s7ok4uw	1441	14	a	a	DT
cord-001835-0s7ok4uw	1441	15	RNA	RNA	NNP
cord-001835-0s7ok4uw	1441	16	kink	kink	NN
cord-001835-0s7ok4uw	1441	17	-	-	HYPH
cord-001835-0s7ok4uw	1441	18	turn	turn	JJ
cord-001835-0s7ok4uw	1441	19	motif	motif	NN
cord-001835-0s7ok4uw	1441	20	,	,	,
cord-001835-0s7ok4uw	1441	21	which	which	WDT
cord-001835-0s7ok4uw	1441	22	is	be	VBZ
cord-001835-0s7ok4uw	1441	23	characterized	characterize	VBN
cord-001835-0s7ok4uw	1441	24	by	by	IN
cord-001835-0s7ok4uw	1441	25	a	a	DT
cord-001835-0s7ok4uw	1441	26	sharp	sharp	JJ
cord-001835-0s7ok4uw	1441	27	bend	bend	NN
cord-001835-0s7ok4uw	1441	28	in	in	IN
cord-001835-0s7ok4uw	1441	29	the	the	DT
cord-001835-0s7ok4uw	1441	30	phosphodiester	phosphodiester	NN
cord-001835-0s7ok4uw	1441	31	backbone	backbone	NN
cord-001835-0s7ok4uw	1441	32	due	due	JJ
cord-001835-0s7ok4uw	1441	33	to	to	IN
cord-001835-0s7ok4uw	1441	34	unpaired	unpaired	JJ
cord-001835-0s7ok4uw	1441	35	nucleotides	nucleotide	NNS
cord-001835-0s7ok4uw	1441	36	and	and	CC
cord-001835-0s7ok4uw	1441	37	internal	internal	JJ
cord-001835-0s7ok4uw	1441	38	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	1441	39	interactions	interaction	NNS
cord-001835-0s7ok4uw	1441	40	.	.	.
cord-001835-0s7ok4uw	1442	1	L30e	l30e	IN
cord-001835-0s7ok4uw	1442	2	structural	structural	JJ
cord-001835-0s7ok4uw	1442	3	flexibility	flexibility	NN
cord-001835-0s7ok4uw	1442	4	at	at	IN
cord-001835-0s7ok4uw	1442	5	the	the	DT
cord-001835-0s7ok4uw	1442	6	RNA	RNA	NNP
cord-001835-0s7ok4uw	1442	7	-	-	HYPH
cord-001835-0s7ok4uw	1442	8	binding	bind	VBG
cord-001835-0s7ok4uw	1442	9	interface	interface	NN
cord-001835-0s7ok4uw	1442	10	makes	make	VBZ
cord-001835-0s7ok4uw	1442	11	such	such	JJ
cord-001835-0s7ok4uw	1442	12	interaction	interaction	NN
cord-001835-0s7ok4uw	1442	13	an	an	DT
cord-001835-0s7ok4uw	1442	14	excellent	excellent	JJ
cord-001835-0s7ok4uw	1442	15	model	model	NN
cord-001835-0s7ok4uw	1442	16	to	to	TO
cord-001835-0s7ok4uw	1442	17	explore	explore	VB
cord-001835-0s7ok4uw	1442	18	the	the	DT
cord-001835-0s7ok4uw	1442	19	energetics	energetic	NNS
cord-001835-0s7ok4uw	1442	20	of	of	IN
cord-001835-0s7ok4uw	1442	21	RNA	RNA	NNP
cord-001835-0s7ok4uw	1442	22	protein	protein	NN
cord-001835-0s7ok4uw	1442	23	binding	binding	NN
cord-001835-0s7ok4uw	1442	24	.	.	.
cord-001835-0s7ok4uw	1443	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1443	2	made	make	VBD
cord-001835-0s7ok4uw	1443	3	L30e	L30e	NNS
cord-001835-0s7ok4uw	1443	4	K28A	K28A	NNP
cord-001835-0s7ok4uw	1443	5	,	,	,
cord-001835-0s7ok4uw	1443	6	F85A	F85A	NNP
cord-001835-0s7ok4uw	1443	7	,	,	,
cord-001835-0s7ok4uw	1443	8	and	and	CC
cord-001835-0s7ok4uw	1443	9	F85W	F85W	NNP
cord-001835-0s7ok4uw	1443	10	mutants	mutant	NNS
cord-001835-0s7ok4uw	1443	11	to	to	TO
cord-001835-0s7ok4uw	1443	12	quantify	quantify	VB
cord-001835-0s7ok4uw	1443	13	the	the	DT
cord-001835-0s7ok4uw	1443	14	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	1443	15	contributions	contribution	NNS
cord-001835-0s7ok4uw	1443	16	of	of	IN
cord-001835-0s7ok4uw	1443	17	such	such	JJ
cord-001835-0s7ok4uw	1443	18	interactions	interaction	NNS
cord-001835-0s7ok4uw	1443	19	to	to	IN
cord-001835-0s7ok4uw	1443	20	the	the	DT
cord-001835-0s7ok4uw	1443	21	protein	protein	NN
cord-001835-0s7ok4uw	1443	22	-	-	HYPH
cord-001835-0s7ok4uw	1443	23	RNA	RNA	NNP
cord-001835-0s7ok4uw	1443	24	complex	complex	NN
cord-001835-0s7ok4uw	1443	25	.	.	.
cord-001835-0s7ok4uw	1444	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1444	2	used	use	VBD
cord-001835-0s7ok4uw	1444	3	analytical	analytical	JJ
cord-001835-0s7ok4uw	1444	4	ultracentrifugation	ultracentrifugation	NN
cord-001835-0s7ok4uw	1444	5	sedimentation	sedimentation	NN
cord-001835-0s7ok4uw	1444	6	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	1444	7	(	(	-LRB-
cord-001835-0s7ok4uw	1444	8	SE	SE	NNP
cord-001835-0s7ok4uw	1444	9	)	)	-RRB-
cord-001835-0s7ok4uw	1444	10	and	and	CC
cord-001835-0s7ok4uw	1444	11	sedimentation	sedimentation	NN
cord-001835-0s7ok4uw	1444	12	velocity	velocity	NN
cord-001835-0s7ok4uw	1444	13	(	(	-LRB-
cord-001835-0s7ok4uw	1444	14	SV	sv	NN
cord-001835-0s7ok4uw	1444	15	)	)	-RRB-
cord-001835-0s7ok4uw	1444	16	to	to	TO
cord-001835-0s7ok4uw	1444	17	investigate	investigate	VB
cord-001835-0s7ok4uw	1444	18	conformational	conformational	JJ
cord-001835-0s7ok4uw	1444	19	changes	change	NNS
cord-001835-0s7ok4uw	1444	20	and	and	CC
cord-001835-0s7ok4uw	1444	21	protein	protein	NN
cord-001835-0s7ok4uw	1444	22	-	-	HYPH
cord-001835-0s7ok4uw	1444	23	RNA	rna	NN
cord-001835-0s7ok4uw	1444	24	binding	bind	VBG
cord-001835-0s7ok4uw	1444	25	free	free	JJ
cord-001835-0s7ok4uw	1444	26	energy	energy	NN
cord-001835-0s7ok4uw	1444	27	changes	change	NNS
cord-001835-0s7ok4uw	1444	28	due	due	JJ
cord-001835-0s7ok4uw	1444	29	to	to	IN
cord-001835-0s7ok4uw	1444	30	mutations	mutation	NNS
cord-001835-0s7ok4uw	1444	31	.	.	.
cord-001835-0s7ok4uw	1445	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1445	2	computed	compute	VBN
cord-001835-0s7ok4uw	1445	3	changes	change	NNS
cord-001835-0s7ok4uw	1445	4	of	of	IN
cord-001835-0s7ok4uw	1445	5	binding	bind	VBG
cord-001835-0s7ok4uw	1445	6	free	free	JJ
cord-001835-0s7ok4uw	1445	7	energy	energy	NN
cord-001835-0s7ok4uw	1445	8	based	base	VBN
cord-001835-0s7ok4uw	1445	9	on	on	IN
cord-001835-0s7ok4uw	1445	10	the	the	DT
cord-001835-0s7ok4uw	1445	11	sedimentation	sedimentation	NN
cord-001835-0s7ok4uw	1445	12	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	1445	13	experiments	experiment	NNS
cord-001835-0s7ok4uw	1445	14	were	be	VBD
cord-001835-0s7ok4uw	1445	15	consistent	consistent	JJ
cord-001835-0s7ok4uw	1445	16	with	with	IN
cord-001835-0s7ok4uw	1445	17	the	the	DT
cord-001835-0s7ok4uw	1445	18	gel	gel	NN
cord-001835-0s7ok4uw	1445	19	shift	shift	NN
cord-001835-0s7ok4uw	1445	20	assay	assay	NN
cord-001835-0s7ok4uw	1445	21	results	result	NNS
cord-001835-0s7ok4uw	1445	22	.	.	.
cord-001835-0s7ok4uw	1446	1	In	in	IN
cord-001835-0s7ok4uw	1446	2	addition	addition	NN
cord-001835-0s7ok4uw	1446	3	,	,	,
cord-001835-0s7ok4uw	1446	4	sedimentation	sedimentation	NN
cord-001835-0s7ok4uw	1446	5	velocity	velocity	NN
cord-001835-0s7ok4uw	1446	6	experiments	experiment	NNS
cord-001835-0s7ok4uw	1446	7	on	on	IN
cord-001835-0s7ok4uw	1446	8	the	the	DT
cord-001835-0s7ok4uw	1446	9	L30e	L30e	NNS
cord-001835-0s7ok4uw	1446	10	wild	wild	JJ
cord-001835-0s7ok4uw	1446	11	type	type	NN
cord-001835-0s7ok4uw	1446	12	indicate	indicate	VBP
cord-001835-0s7ok4uw	1446	13	that	that	IN
cord-001835-0s7ok4uw	1446	14	protein	protein	NN
cord-001835-0s7ok4uw	1446	15	-	-	HYPH
cord-001835-0s7ok4uw	1446	16	RNA	rna	NN
cord-001835-0s7ok4uw	1446	17	interaction	interaction	NN
cord-001835-0s7ok4uw	1446	18	is	be	VBZ
cord-001835-0s7ok4uw	1446	19	highly	highly	RB
cord-001835-0s7ok4uw	1446	20	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	1446	21	and	and	CC
cord-001835-0s7ok4uw	1446	22	involves	involve	VBZ
cord-001835-0s7ok4uw	1446	23	conformational	conformational	JJ
cord-001835-0s7ok4uw	1446	24	changes	change	NNS
cord-001835-0s7ok4uw	1446	25	of	of	IN
cord-001835-0s7ok4uw	1446	26	the	the	DT
cord-001835-0s7ok4uw	1446	27	kink	kink	NN
cord-001835-0s7ok4uw	1446	28	-	-	HYPH
cord-001835-0s7ok4uw	1446	29	turn	turn	NN
cord-001835-0s7ok4uw	1446	30	RNA	RNA	NNP
cord-001835-0s7ok4uw	1446	31	induced	induce	VBN
cord-001835-0s7ok4uw	1446	32	by	by	IN
cord-001835-0s7ok4uw	1446	33	L30e	l30e	WDT
cord-001835-0s7ok4uw	1446	34	protein	protein	NN
cord-001835-0s7ok4uw	1446	35	.	.	.
cord-001835-0s7ok4uw	1447	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1447	2	results	result	NNS
cord-001835-0s7ok4uw	1447	3	provide	provide	VBP
cord-001835-0s7ok4uw	1447	4	new	new	JJ
cord-001835-0s7ok4uw	1447	5	insights	insight	NNS
cord-001835-0s7ok4uw	1447	6	on	on	IN
cord-001835-0s7ok4uw	1447	7	understanding	understand	VBG
cord-001835-0s7ok4uw	1447	8	the	the	DT
cord-001835-0s7ok4uw	1447	9	binding	binding	NN
cord-001835-0s7ok4uw	1447	10	between	between	IN
cord-001835-0s7ok4uw	1447	11	ribosomal	ribosomal	JJ
cord-001835-0s7ok4uw	1447	12	proteins	protein	NNS
cord-001835-0s7ok4uw	1447	13	and	and	CC
cord-001835-0s7ok4uw	1447	14	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1447	15	RNA	RNA	NNP
cord-001835-0s7ok4uw	1447	16	molecules	molecule	NNS
cord-001835-0s7ok4uw	1447	17	counterpart	counterpart	NN
cord-001835-0s7ok4uw	1447	18	,	,	,
cord-001835-0s7ok4uw	1447	19	which	which	WDT
cord-001835-0s7ok4uw	1447	20	can	can	MD
cord-001835-0s7ok4uw	1447	21	be	be	VB
cord-001835-0s7ok4uw	1447	22	used	use	VBN
cord-001835-0s7ok4uw	1447	23	to	to	TO
cord-001835-0s7ok4uw	1447	24	complement	complement	VB
cord-001835-0s7ok4uw	1447	25	the	the	DT
cord-001835-0s7ok4uw	1447	26	x	x	NN
cord-001835-0s7ok4uw	1447	27	-	-	NN
cord-001835-0s7ok4uw	1447	28	ray	ray	NN
cord-001835-0s7ok4uw	1447	29	structure	structure	NN
cord-001835-0s7ok4uw	1447	30	.	.	.
cord-001835-0s7ok4uw	1448	1	Role	role	NN
cord-001835-0s7ok4uw	1448	2	of	of	IN
cord-001835-0s7ok4uw	1448	3	a	a	DT
cord-001835-0s7ok4uw	1448	4	non	non	JJ
cord-001835-0s7ok4uw	1448	5	-	-	JJ
cord-001835-0s7ok4uw	1448	6	native	native	JJ
cord-001835-0s7ok4uw	1448	7	a	a	DT
cord-001835-0s7ok4uw	1448	8	-	-	HYPH
cord-001835-0s7ok4uw	1448	9	helix	helix	NN
cord-001835-0s7ok4uw	1448	10	in	in	IN
cord-001835-0s7ok4uw	1448	11	the	the	DT
cord-001835-0s7ok4uw	1448	12	folding	folding	NN
cord-001835-0s7ok4uw	1448	13	of	of	IN
cord-001835-0s7ok4uw	1448	14	equine	equine	NN
cord-001835-0s7ok4uw	1448	15	b	b	NN
cord-001835-0s7ok4uw	1448	16	-	-	:
cord-001835-0s7ok4uw	1448	17	lactoglobulin	lactoglobulin	NNP
cord-001835-0s7ok4uw	1448	18	Takahiro	Takahiro	NNP
cord-001835-0s7ok4uw	1448	19	Okabe	Okabe	NNP
cord-001835-0s7ok4uw	1448	20	1	1	CD
cord-001835-0s7ok4uw	1448	21	,	,	,
cord-001835-0s7ok4uw	1448	22	Toshiaki	Toshiaki	NNP
cord-001835-0s7ok4uw	1448	23	Miyajima	Miyajima	NNP
cord-001835-0s7ok4uw	1448	24	1	1	CD
cord-001835-0s7ok4uw	1448	25	,	,	,
cord-001835-0s7ok4uw	1448	26	Kanako	Kanako	NNP
cord-001835-0s7ok4uw	1448	27	Nakagawa	Nakagawa	NNP
cord-001835-0s7ok4uw	1448	28	1	1	CD
cord-001835-0s7ok4uw	1448	29	,	,	,
cord-001835-0s7ok4uw	1448	30	Seiichi	Seiichi	NNP
cord-001835-0s7ok4uw	1448	31	Tsukamoto	Tsukamoto	NNP
cord-001835-0s7ok4uw	1448	32	1	1	CD
cord-001835-0s7ok4uw	1448	33	,	,	,
cord-001835-0s7ok4uw	1448	34	Kazuo	Kazuo	NNP
cord-001835-0s7ok4uw	1448	35	Fujiwara	Fujiwara	NNP
cord-001835-0s7ok4uw	1448	36	1	1	CD
cord-001835-0s7ok4uw	1448	37	,	,	,
cord-001835-0s7ok4uw	1449	1	Masamichi	Masamichi	NNP
cord-001835-0s7ok4uw	1449	2	Ikeguchi	Ikeguchi	NNP
cord-001835-0s7ok4uw	1449	3	1	1	CD
cord-001835-0s7ok4uw	1449	4	1	1	CD
cord-001835-0s7ok4uw	1449	5	Equine	Equine	NNP
cord-001835-0s7ok4uw	1449	6	b	b	NN
cord-001835-0s7ok4uw	1449	7	-	-	:
cord-001835-0s7ok4uw	1449	8	lactoglobulin	lactoglobulin	NNP
cord-001835-0s7ok4uw	1449	9	is	be	VBZ
cord-001835-0s7ok4uw	1449	10	a	a	DT
cord-001835-0s7ok4uw	1449	11	small	small	JJ
cord-001835-0s7ok4uw	1449	12	globular	globular	JJ
cord-001835-0s7ok4uw	1449	13	protein	protein	NN
cord-001835-0s7ok4uw	1449	14	(	(	-LRB-
cord-001835-0s7ok4uw	1449	15	162	162	CD
cord-001835-0s7ok4uw	1449	16	residues	residue	NNS
cord-001835-0s7ok4uw	1449	17	)	)	-RRB-
cord-001835-0s7ok4uw	1449	18	.	.	.
cord-001835-0s7ok4uw	1450	1	Although	although	IN
cord-001835-0s7ok4uw	1450	2	ELG	ELG	NNP
cord-001835-0s7ok4uw	1450	3	adopts	adopt	VBZ
cord-001835-0s7ok4uw	1450	4	a	a	DT
cord-001835-0s7ok4uw	1450	5	predominantly	predominantly	RB
cord-001835-0s7ok4uw	1450	6	b	b	NN
cord-001835-0s7ok4uw	1450	7	-	-	HYPH
cord-001835-0s7ok4uw	1450	8	sheet	sheet	NN
cord-001835-0s7ok4uw	1450	9	structure	structure	NN
cord-001835-0s7ok4uw	1450	10	consisting	consist	VBG
cord-001835-0s7ok4uw	1450	11	of	of	IN
cord-001835-0s7ok4uw	1450	12	nine	nine	CD
cord-001835-0s7ok4uw	1450	13	anti	anti	JJ
cord-001835-0s7ok4uw	1450	14	-	-	JJ
cord-001835-0s7ok4uw	1450	15	parallel	parallel	JJ
cord-001835-0s7ok4uw	1450	16	b	b	NN
cord-001835-0s7ok4uw	1450	17	-	-	HYPH
cord-001835-0s7ok4uw	1450	18	strands	strand	NNS
cord-001835-0s7ok4uw	1450	19	(	(	-LRB-
cord-001835-0s7ok4uw	1450	20	A	a	NN
cord-001835-0s7ok4uw	1450	21	-	-	:
cord-001835-0s7ok4uw	1450	22	I	i	NN
cord-001835-0s7ok4uw	1450	23	)	)	-RRB-
cord-001835-0s7ok4uw	1450	24	and	and	CC
cord-001835-0s7ok4uw	1450	25	one	one	CD
cord-001835-0s7ok4uw	1450	26	major	major	JJ
cord-001835-0s7ok4uw	1450	27	a	a	DT
cord-001835-0s7ok4uw	1450	28	-	-	HYPH
cord-001835-0s7ok4uw	1450	29	helix	helix	NN
cord-001835-0s7ok4uw	1450	30	in	in	IN
cord-001835-0s7ok4uw	1450	31	the	the	DT
cord-001835-0s7ok4uw	1450	32	native	native	JJ
cord-001835-0s7ok4uw	1450	33	state	state	NN
cord-001835-0s7ok4uw	1450	34	,	,	,
cord-001835-0s7ok4uw	1450	35	it	-PRON-	PRP
cord-001835-0s7ok4uw	1450	36	has	have	VBZ
cord-001835-0s7ok4uw	1450	37	been	be	VBN
cord-001835-0s7ok4uw	1450	38	shown	show	VBN
cord-001835-0s7ok4uw	1450	39	that	that	IN
cord-001835-0s7ok4uw	1450	40	a	a	DT
cord-001835-0s7ok4uw	1450	41	non	non	JJ
cord-001835-0s7ok4uw	1450	42	-	-	JJ
cord-001835-0s7ok4uw	1450	43	native	native	JJ
cord-001835-0s7ok4uw	1450	44	a	a	DT
cord-001835-0s7ok4uw	1450	45	-	-	HYPH
cord-001835-0s7ok4uw	1450	46	helical	helical	JJ
cord-001835-0s7ok4uw	1450	47	intermediate	intermediate	NN
cord-001835-0s7ok4uw	1450	48	accumulates	accumulate	VBZ
cord-001835-0s7ok4uw	1450	49	during	during	IN
cord-001835-0s7ok4uw	1450	50	the	the	DT
cord-001835-0s7ok4uw	1450	51	burstphase	burstphase	NN
cord-001835-0s7ok4uw	1450	52	of	of	IN
cord-001835-0s7ok4uw	1450	53	folding	fold	VBG
cord-001835-0s7ok4uw	1450	54	reaction	reaction	NN
cord-001835-0s7ok4uw	1450	55	from	from	IN
cord-001835-0s7ok4uw	1450	56	the	the	DT
cord-001835-0s7ok4uw	1450	57	unfolded	unfold	VBN
cord-001835-0s7ok4uw	1450	58	state	state	NN
cord-001835-0s7ok4uw	1450	59	in	in	IN
cord-001835-0s7ok4uw	1450	60	the	the	DT
cord-001835-0s7ok4uw	1450	61	concentrated	concentrated	JJ
cord-001835-0s7ok4uw	1450	62	denaturant	denaturant	JJ
cord-001835-0s7ok4uw	1450	63	.	.	.
cord-001835-0s7ok4uw	1451	1	To	to	TO
cord-001835-0s7ok4uw	1451	2	ask	ask	VB
cord-001835-0s7ok4uw	1451	3	whether	whether	IN
cord-001835-0s7ok4uw	1451	4	the	the	DT
cord-001835-0s7ok4uw	1451	5	non	non	JJ
cord-001835-0s7ok4uw	1451	6	-	-	JJ
cord-001835-0s7ok4uw	1451	7	native	native	JJ
cord-001835-0s7ok4uw	1451	8	helix	helix	NN
cord-001835-0s7ok4uw	1451	9	formation	formation	NN
cord-001835-0s7ok4uw	1451	10	is	be	VBZ
cord-001835-0s7ok4uw	1451	11	important	important	JJ
cord-001835-0s7ok4uw	1451	12	for	for	IN
cord-001835-0s7ok4uw	1451	13	acquiring	acquire	VBG
cord-001835-0s7ok4uw	1451	14	the	the	DT
cord-001835-0s7ok4uw	1451	15	native	native	JJ
cord-001835-0s7ok4uw	1451	16	b	b	NN
cord-001835-0s7ok4uw	1451	17	-	-	HYPH
cord-001835-0s7ok4uw	1451	18	sheet	sheet	NN
cord-001835-0s7ok4uw	1451	19	structure	structure	NN
cord-001835-0s7ok4uw	1451	20	,	,	,
cord-001835-0s7ok4uw	1451	21	we	-PRON-	PRP
cord-001835-0s7ok4uw	1451	22	determined	determine	VBD
cord-001835-0s7ok4uw	1451	23	first	first	RB
cord-001835-0s7ok4uw	1451	24	where	where	WRB
cord-001835-0s7ok4uw	1451	25	the	the	DT
cord-001835-0s7ok4uw	1451	26	non	non	JJ
cord-001835-0s7ok4uw	1451	27	-	-	JJ
cord-001835-0s7ok4uw	1451	28	native	native	JJ
cord-001835-0s7ok4uw	1451	29	a	a	DT
cord-001835-0s7ok4uw	1451	30	-	-	HYPH
cord-001835-0s7ok4uw	1451	31	helix	helix	NN
cord-001835-0s7ok4uw	1451	32	is	be	VBZ
cord-001835-0s7ok4uw	1451	33	formed	form	VBN
cord-001835-0s7ok4uw	1451	34	.	.	.
cord-001835-0s7ok4uw	1452	1	A	a	DT
cord-001835-0s7ok4uw	1452	2	stable	stable	JJ
cord-001835-0s7ok4uw	1452	3	analogue	analogue	NN
cord-001835-0s7ok4uw	1452	4	of	of	IN
cord-001835-0s7ok4uw	1452	5	the	the	DT
cord-001835-0s7ok4uw	1452	6	burst	burst	NN
cord-001835-0s7ok4uw	1452	7	-	-	HYPH
cord-001835-0s7ok4uw	1452	8	phase	phase	NN
cord-001835-0s7ok4uw	1452	9	folding	folding	NN
cord-001835-0s7ok4uw	1452	10	intermediate	intermediate	JJ
cord-001835-0s7ok4uw	1452	11	was	be	VBD
cord-001835-0s7ok4uw	1452	12	observed	observe	VBN
cord-001835-0s7ok4uw	1452	13	at	at	IN
cord-001835-0s7ok4uw	1452	14	acid	acid	NN
cord-001835-0s7ok4uw	1452	15	pH	pH	NNP
cord-001835-0s7ok4uw	1452	16	(	(	-LRB-
cord-001835-0s7ok4uw	1452	17	A	a	DT
cord-001835-0s7ok4uw	1452	18	state	state	NN
cord-001835-0s7ok4uw	1452	19	)	)	-RRB-
cord-001835-0s7ok4uw	1452	20	.	.	.
cord-001835-0s7ok4uw	1453	1	The	the	DT
cord-001835-0s7ok4uw	1453	2	amide	amide	NN
cord-001835-0s7ok4uw	1453	3	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	1453	4	exchange	exchange	NN
cord-001835-0s7ok4uw	1453	5	experiment	experiment	NN
cord-001835-0s7ok4uw	1453	6	and	and	CC
cord-001835-0s7ok4uw	1453	7	proline	proline	NN
cord-001835-0s7ok4uw	1453	8	-	-	HYPH
cord-001835-0s7ok4uw	1453	9	scanning	scan	VBG
cord-001835-0s7ok4uw	1453	10	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	1453	11	experiment	experiment	NN
cord-001835-0s7ok4uw	1453	12	have	have	VBP
cord-001835-0s7ok4uw	1453	13	shown	show	VBN
cord-001835-0s7ok4uw	1453	14	that	that	IN
cord-001835-0s7ok4uw	1453	15	the	the	DT
cord-001835-0s7ok4uw	1453	16	non	non	JJ
cord-001835-0s7ok4uw	1453	17	-	-	JJ
cord-001835-0s7ok4uw	1453	18	native	native	JJ
cord-001835-0s7ok4uw	1453	19	a	a	DT
cord-001835-0s7ok4uw	1453	20	-	-	HYPH
cord-001835-0s7ok4uw	1453	21	helix	helix	NN
cord-001835-0s7ok4uw	1453	22	is	be	VBZ
cord-001835-0s7ok4uw	1453	23	formed	form	VBN
cord-001835-0s7ok4uw	1453	24	at	at	IN
cord-001835-0s7ok4uw	1453	25	the	the	DT
cord-001835-0s7ok4uw	1453	26	region	region	NN
cord-001835-0s7ok4uw	1453	27	corresponding	correspond	VBG
cord-001835-0s7ok4uw	1453	28	to	to	IN
cord-001835-0s7ok4uw	1453	29	the	the	DT
cord-001835-0s7ok4uw	1453	30	H	H	NNP
cord-001835-0s7ok4uw	1453	31	strand	strand	NN
cord-001835-0s7ok4uw	1453	32	in	in	IN
cord-001835-0s7ok4uw	1453	33	the	the	DT
cord-001835-0s7ok4uw	1453	34	A	A	NNP
cord-001835-0s7ok4uw	1453	35	state	state	NN
cord-001835-0s7ok4uw	1453	36	.	.	.
cord-001835-0s7ok4uw	1454	1	To	to	TO
cord-001835-0s7ok4uw	1454	2	investigate	investigate	VB
cord-001835-0s7ok4uw	1454	3	the	the	DT
cord-001835-0s7ok4uw	1454	4	role	role	NN
cord-001835-0s7ok4uw	1454	5	of	of	IN
cord-001835-0s7ok4uw	1454	6	this	this	DT
cord-001835-0s7ok4uw	1454	7	non	non	JJ
cord-001835-0s7ok4uw	1454	8	-	-	JJ
cord-001835-0s7ok4uw	1454	9	native	native	JJ
cord-001835-0s7ok4uw	1454	10	a	a	DT
cord-001835-0s7ok4uw	1454	11	-	-	HYPH
cord-001835-0s7ok4uw	1454	12	helix	helix	NN
cord-001835-0s7ok4uw	1454	13	on	on	IN
cord-001835-0s7ok4uw	1454	14	refolding	refolde	VBG
cord-001835-0s7ok4uw	1454	15	reaction	reaction	NN
cord-001835-0s7ok4uw	1454	16	of	of	IN
cord-001835-0s7ok4uw	1454	17	ELG	ELG	NNP
cord-001835-0s7ok4uw	1454	18	,	,	,
cord-001835-0s7ok4uw	1454	19	we	-PRON-	PRP
cord-001835-0s7ok4uw	1454	20	constructed	construct	VBD
cord-001835-0s7ok4uw	1454	21	several	several	JJ
cord-001835-0s7ok4uw	1454	22	mutant	mutant	JJ
cord-001835-0s7ok4uw	1454	23	proteins	protein	NNS
cord-001835-0s7ok4uw	1454	24	,	,	,
cord-001835-0s7ok4uw	1454	25	which	which	WDT
cord-001835-0s7ok4uw	1454	26	were	be	VBD
cord-001835-0s7ok4uw	1454	27	designed	design	VBN
cord-001835-0s7ok4uw	1454	28	to	to	TO
cord-001835-0s7ok4uw	1454	29	destabilize	destabilize	VB
cord-001835-0s7ok4uw	1454	30	the	the	DT
cord-001835-0s7ok4uw	1454	31	nonnative	nonnative	JJ
cord-001835-0s7ok4uw	1454	32	a	a	DT
cord-001835-0s7ok4uw	1454	33	-	-	HYPH
cord-001835-0s7ok4uw	1454	34	helix	helix	NN
cord-001835-0s7ok4uw	1454	35	in	in	IN
cord-001835-0s7ok4uw	1454	36	the	the	DT
cord-001835-0s7ok4uw	1454	37	folding	folding	NN
cord-001835-0s7ok4uw	1454	38	intermediate	intermediate	JJ
cord-001835-0s7ok4uw	1454	39	without	without	IN
cord-001835-0s7ok4uw	1454	40	perturbation	perturbation	NN
cord-001835-0s7ok4uw	1454	41	on	on	IN
cord-001835-0s7ok4uw	1454	42	the	the	DT
cord-001835-0s7ok4uw	1454	43	native	native	JJ
cord-001835-0s7ok4uw	1454	44	structure	structure	NN
cord-001835-0s7ok4uw	1454	45	.	.	.
cord-001835-0s7ok4uw	1455	1	A	a	DT
cord-001835-0s7ok4uw	1455	2	mutant	mutant	NN
cord-001835-0s7ok4uw	1455	3	,	,	,
cord-001835-0s7ok4uw	1455	4	A123	A123	NNP
cord-001835-0s7ok4uw	1455	5	T	T	NNP
cord-001835-0s7ok4uw	1455	6	,	,	,
cord-001835-0s7ok4uw	1455	7	fulfilled	fulfil	VBD
cord-001835-0s7ok4uw	1455	8	this	this	DT
cord-001835-0s7ok4uw	1455	9	requirement	requirement	NN
cord-001835-0s7ok4uw	1455	10	,	,	,
cord-001835-0s7ok4uw	1455	11	that	that	RB
cord-001835-0s7ok4uw	1455	12	is	is	RB
cord-001835-0s7ok4uw	1455	13	,	,	,
cord-001835-0s7ok4uw	1455	14	A123	A123	NNP
cord-001835-0s7ok4uw	1455	15	T	T	NNP
cord-001835-0s7ok4uw	1455	16	showed	show	VBD
cord-001835-0s7ok4uw	1455	17	a	a	DT
cord-001835-0s7ok4uw	1455	18	native	native	JJ
cord-001835-0s7ok4uw	1455	19	structure	structure	NN
cord-001835-0s7ok4uw	1455	20	similar	similar	JJ
cord-001835-0s7ok4uw	1455	21	to	to	IN
cord-001835-0s7ok4uw	1455	22	that	that	DT
cord-001835-0s7ok4uw	1455	23	of	of	IN
cord-001835-0s7ok4uw	1455	24	the	the	DT
cord-001835-0s7ok4uw	1455	25	wildtype	wildtype	JJ
cord-001835-0s7ok4uw	1455	26	protein	protein	NN
cord-001835-0s7ok4uw	1455	27	,	,	,
cord-001835-0s7ok4uw	1455	28	and	and	CC
cord-001835-0s7ok4uw	1455	29	largely	largely	RB
cord-001835-0s7ok4uw	1455	30	reduced	reduce	VBN
cord-001835-0s7ok4uw	1455	31	CD	cd	NN
cord-001835-0s7ok4uw	1455	32	intensity	intensity	NN
cord-001835-0s7ok4uw	1455	33	in	in	IN
cord-001835-0s7ok4uw	1455	34	the	the	DT
cord-001835-0s7ok4uw	1455	35	A	A	NNP
cord-001835-0s7ok4uw	1455	36	state	state	NN
cord-001835-0s7ok4uw	1455	37	.	.	.
cord-001835-0s7ok4uw	1456	1	Then	then	RB
cord-001835-0s7ok4uw	1456	2	,	,	,
cord-001835-0s7ok4uw	1456	3	the	the	DT
cord-001835-0s7ok4uw	1456	4	refolding	refolde	VBG
cord-001835-0s7ok4uw	1456	5	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	1456	6	were	be	VBD
cord-001835-0s7ok4uw	1456	7	investigated	investigate	VBN
cord-001835-0s7ok4uw	1456	8	by	by	IN
cord-001835-0s7ok4uw	1456	9	the	the	DT
cord-001835-0s7ok4uw	1456	10	CD	cd	NN
cord-001835-0s7ok4uw	1456	11	and	and	CC
cord-001835-0s7ok4uw	1456	12	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1456	13	stopped	stop	VBD
cord-001835-0s7ok4uw	1456	14	-	-	HYPH
cord-001835-0s7ok4uw	1456	15	flow	flow	NN
cord-001835-0s7ok4uw	1456	16	method	method	NN
cord-001835-0s7ok4uw	1456	17	.	.	.
cord-001835-0s7ok4uw	1457	1	A123	A123	NNP
cord-001835-0s7ok4uw	1457	2	T	T	NNP
cord-001835-0s7ok4uw	1457	3	mutation	mutation	NN
cord-001835-0s7ok4uw	1457	4	resulted	result	VBD
cord-001835-0s7ok4uw	1457	5	in	in	IN
cord-001835-0s7ok4uw	1457	6	reduction	reduction	NN
cord-001835-0s7ok4uw	1457	7	of	of	IN
cord-001835-0s7ok4uw	1457	8	the	the	DT
cord-001835-0s7ok4uw	1457	9	burst	burst	NN
cord-001835-0s7ok4uw	1457	10	-	-	HYPH
cord-001835-0s7ok4uw	1457	11	phase	phase	NN
cord-001835-0s7ok4uw	1457	12	CD	cd	NN
cord-001835-0s7ok4uw	1457	13	intensity	intensity	NN
cord-001835-0s7ok4uw	1457	14	,	,	,
cord-001835-0s7ok4uw	1457	15	which	which	WDT
cord-001835-0s7ok4uw	1457	16	confirmed	confirm	VBD
cord-001835-0s7ok4uw	1457	17	that	that	IN
cord-001835-0s7ok4uw	1457	18	the	the	DT
cord-001835-0s7ok4uw	1457	19	non	non	JJ
cord-001835-0s7ok4uw	1457	20	-	-	JJ
cord-001835-0s7ok4uw	1457	21	native	native	JJ
cord-001835-0s7ok4uw	1457	22	a	a	DT
cord-001835-0s7ok4uw	1457	23	-	-	HYPH
cord-001835-0s7ok4uw	1457	24	helix	helix	NN
cord-001835-0s7ok4uw	1457	25	is	be	VBZ
cord-001835-0s7ok4uw	1457	26	formed	form	VBN
cord-001835-0s7ok4uw	1457	27	around	around	IN
cord-001835-0s7ok4uw	1457	28	the	the	DT
cord-001835-0s7ok4uw	1457	29	H	h	NN
cord-001835-0s7ok4uw	1457	30	strand	strand	NN
cord-001835-0s7ok4uw	1457	31	region	region	NN
cord-001835-0s7ok4uw	1457	32	.	.	.
cord-001835-0s7ok4uw	1458	1	Subsequent	subsequent	JJ
cord-001835-0s7ok4uw	1458	2	to	to	IN
cord-001835-0s7ok4uw	1458	3	the	the	DT
cord-001835-0s7ok4uw	1458	4	burst	burst	NN
cord-001835-0s7ok4uw	1458	5	-	-	HYPH
cord-001835-0s7ok4uw	1458	6	phase	phase	NN
cord-001835-0s7ok4uw	1458	7	,	,	,
cord-001835-0s7ok4uw	1458	8	four	four	CD
cord-001835-0s7ok4uw	1458	9	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1458	10	phases	phase	NNS
cord-001835-0s7ok4uw	1458	11	were	be	VBD
cord-001835-0s7ok4uw	1458	12	observed	observe	VBN
cord-001835-0s7ok4uw	1458	13	for	for	IN
cord-001835-0s7ok4uw	1458	14	A123	A123	NNP
cord-001835-0s7ok4uw	1458	15	T	T	NNP
cord-001835-0s7ok4uw	1458	16	and	and	CC
cord-001835-0s7ok4uw	1458	17	the	the	DT
cord-001835-0s7ok4uw	1458	18	wildtype	wildtype	JJ
cord-001835-0s7ok4uw	1458	19	protein	protein	NN
cord-001835-0s7ok4uw	1458	20	.	.	.
cord-001835-0s7ok4uw	1459	1	Importantly	importantly	RB
cord-001835-0s7ok4uw	1459	2	,	,	,
cord-001835-0s7ok4uw	1459	3	the	the	DT
cord-001835-0s7ok4uw	1459	4	folding	folding	NN
cord-001835-0s7ok4uw	1459	5	rate	rate	NN
cord-001835-0s7ok4uw	1459	6	constants	constant	NNS
cord-001835-0s7ok4uw	1459	7	of	of	IN
cord-001835-0s7ok4uw	1459	8	the	the	DT
cord-001835-0s7ok4uw	1459	9	four	four	CD
cord-001835-0s7ok4uw	1459	10	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1459	11	phases	phase	NNS
cord-001835-0s7ok4uw	1459	12	were	be	VBD
cord-001835-0s7ok4uw	1459	13	similar	similar	JJ
cord-001835-0s7ok4uw	1459	14	between	between	IN
cord-001835-0s7ok4uw	1459	15	both	both	DT
cord-001835-0s7ok4uw	1459	16	proteins	protein	NNS
cord-001835-0s7ok4uw	1459	17	.	.	.
cord-001835-0s7ok4uw	1460	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1460	2	,	,	,
cord-001835-0s7ok4uw	1460	3	interrupted	interrupted	JJ
cord-001835-0s7ok4uw	1460	4	refolding	refolde	VBG
cord-001835-0s7ok4uw	1460	5	experiments	experiment	NNS
cord-001835-0s7ok4uw	1460	6	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	1460	7	that	that	IN
cord-001835-0s7ok4uw	1460	8	the	the	DT
cord-001835-0s7ok4uw	1460	9	native	native	JJ
cord-001835-0s7ok4uw	1460	10	state	state	NN
cord-001835-0s7ok4uw	1460	11	was	be	VBD
cord-001835-0s7ok4uw	1460	12	formed	form	VBN
cord-001835-0s7ok4uw	1460	13	in	in	IN
cord-001835-0s7ok4uw	1460	14	the	the	DT
cord-001835-0s7ok4uw	1460	15	two	two	CD
cord-001835-0s7ok4uw	1460	16	parallel	parallel	JJ
cord-001835-0s7ok4uw	1460	17	pathways	pathway	NNS
cord-001835-0s7ok4uw	1460	18	in	in	IN
cord-001835-0s7ok4uw	1460	19	the	the	DT
cord-001835-0s7ok4uw	1460	20	two	two	CD
cord-001835-0s7ok4uw	1460	21	slower	slow	JJR
cord-001835-0s7ok4uw	1460	22	phases	phase	NNS
cord-001835-0s7ok4uw	1460	23	of	of	IN
cord-001835-0s7ok4uw	1460	24	the	the	DT
cord-001835-0s7ok4uw	1460	25	four	four	CD
cord-001835-0s7ok4uw	1460	26	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1460	27	phases	phase	NNS
cord-001835-0s7ok4uw	1460	28	.	.	.
cord-001835-0s7ok4uw	1461	1	The	the	DT
cord-001835-0s7ok4uw	1461	2	relative	relative	JJ
cord-001835-0s7ok4uw	1461	3	amplitudes	amplitude	NNS
cord-001835-0s7ok4uw	1461	4	of	of	IN
cord-001835-0s7ok4uw	1461	5	the	the	DT
cord-001835-0s7ok4uw	1461	6	two	two	CD
cord-001835-0s7ok4uw	1461	7	pathways	pathway	NNS
cord-001835-0s7ok4uw	1461	8	were	be	VBD
cord-001835-0s7ok4uw	1461	9	similar	similar	JJ
cord-001835-0s7ok4uw	1461	10	between	between	IN
cord-001835-0s7ok4uw	1461	11	A123	A123	NNS
cord-001835-0s7ok4uw	1461	12	T	T	NNP
cord-001835-0s7ok4uw	1461	13	and	and	CC
cord-001835-0s7ok4uw	1461	14	the	the	DT
cord-001835-0s7ok4uw	1461	15	wild	wild	JJ
cord-001835-0s7ok4uw	1461	16	-	-	HYPH
cord-001835-0s7ok4uw	1461	17	type	type	NN
cord-001835-0s7ok4uw	1461	18	protein	protein	NN
cord-001835-0s7ok4uw	1461	19	.	.	.
cord-001835-0s7ok4uw	1462	1	These	these	DT
cord-001835-0s7ok4uw	1462	2	results	result	NNS
cord-001835-0s7ok4uw	1462	3	clearly	clearly	RB
cord-001835-0s7ok4uw	1462	4	showed	show	VBD
cord-001835-0s7ok4uw	1462	5	that	that	IN
cord-001835-0s7ok4uw	1462	6	the	the	DT
cord-001835-0s7ok4uw	1462	7	formation	formation	NN
cord-001835-0s7ok4uw	1462	8	of	of	IN
cord-001835-0s7ok4uw	1462	9	the	the	DT
cord-001835-0s7ok4uw	1462	10	non	non	JJ
cord-001835-0s7ok4uw	1462	11	-	-	JJ
cord-001835-0s7ok4uw	1462	12	native	native	JJ
cord-001835-0s7ok4uw	1462	13	helix	helix	NN
cord-001835-0s7ok4uw	1462	14	has	have	VBZ
cord-001835-0s7ok4uw	1462	15	little	little	JJ
cord-001835-0s7ok4uw	1462	16	effect	effect	NN
cord-001835-0s7ok4uw	1462	17	on	on	IN
cord-001835-0s7ok4uw	1462	18	the	the	DT
cord-001835-0s7ok4uw	1462	19	folding	folding	NN
cord-001835-0s7ok4uw	1462	20	rates	rate	NNS
cord-001835-0s7ok4uw	1462	21	and	and	CC
cord-001835-0s7ok4uw	1462	22	pathways	pathway	NNS
cord-001835-0s7ok4uw	1462	23	,	,	,
cord-001835-0s7ok4uw	1462	24	and	and	CC
cord-001835-0s7ok4uw	1462	25	suggested	suggest	VBD
cord-001835-0s7ok4uw	1462	26	that	that	IN
cord-001835-0s7ok4uw	1462	27	the	the	DT
cord-001835-0s7ok4uw	1462	28	non	non	JJ
cord-001835-0s7ok4uw	1462	29	-	-	JJ
cord-001835-0s7ok4uw	1462	30	native	native	JJ
cord-001835-0s7ok4uw	1462	31	helix	helix	NN
cord-001835-0s7ok4uw	1462	32	formation	formation	NN
cord-001835-0s7ok4uw	1462	33	may	may	MD
cord-001835-0s7ok4uw	1462	34	not	not	RB
cord-001835-0s7ok4uw	1462	35	be	be	VB
cord-001835-0s7ok4uw	1462	36	a	a	DT
cord-001835-0s7ok4uw	1462	37	severe	severe	JJ
cord-001835-0s7ok4uw	1462	38	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1462	39	trap	trap	NN
cord-001835-0s7ok4uw	1462	40	for	for	IN
cord-001835-0s7ok4uw	1462	41	protein	protein	NN
cord-001835-0s7ok4uw	1462	42	folding	folding	NN
cord-001835-0s7ok4uw	1462	43	reaction	reaction	NN
cord-001835-0s7ok4uw	1462	44	.	.	.
cord-001835-0s7ok4uw	1463	1	Impact	impact	NN
cord-001835-0s7ok4uw	1463	2	of	of	IN
cord-001835-0s7ok4uw	1463	3	the	the	DT
cord-001835-0s7ok4uw	1463	4	chaperonin	chaperonin	NNS
cord-001835-0s7ok4uw	1463	5	CCT	CCT	NNP
cord-001835-0s7ok4uw	1463	6	in	in	IN
cord-001835-0s7ok4uw	1463	7	a	a	DT
cord-001835-0s7ok4uw	1463	8	-	-	HYPH
cord-001835-0s7ok4uw	1463	9	Synuclein(A53	Synuclein(A53	NNP
cord-001835-0s7ok4uw	1463	10	T	t	NN
cord-001835-0s7ok4uw	1463	11	)	)	-RRB-
cord-001835-0s7ok4uw	1463	12	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1463	13	fibrils	fibril	NNS
cord-001835-0s7ok4uw	1463	14	assembly	assembly	NN
cord-001835-0s7ok4uw	1464	1	Ahudrey	Ahudrey	NNP
cord-001835-0s7ok4uw	1464	2	Leal_Quintero	leal_quintero	CD
cord-001835-0s7ok4uw	1464	3	1	1	CD
cord-001835-0s7ok4uw	1465	1	,	,	,
cord-001835-0s7ok4uw	1465	2	Javier	Javier	NNP
cord-001835-0s7ok4uw	1465	3	Martinez	Martinez	NNP
cord-001835-0s7ok4uw	1465	4	-	-	HYPH
cord-001835-0s7ok4uw	1465	5	Sabando	Sabando	NNP
cord-001835-0s7ok4uw	1465	6	1	1	CD
cord-001835-0s7ok4uw	1465	7	,	,	,
cord-001835-0s7ok4uw	1465	8	Jose	Jose	NNP
cord-001835-0s7ok4uw	1465	9	Mar	Mar	NNP
cord-001835-0s7ok4uw	1465	10	ıa	ıa	VBZ
cord-001835-0s7ok4uw	1465	11	Valpuesta	Valpuesta	NNP
cord-001835-0s7ok4uw	1465	12	1	1	CD
cord-001835-0s7ok4uw	1466	1	,	,	,
cord-001835-0s7ok4uw	1466	2	Begoña	Begoña	NNP
cord-001835-0s7ok4uw	1466	3	Sot	Sot	NNP
cord-001835-0s7ok4uw	1466	4	1	1	CD
cord-001835-0s7ok4uw	1466	5	1	1	CD
cord-001835-0s7ok4uw	1466	6	Centro	Centro	NNP
cord-001835-0s7ok4uw	1466	7	Nacional	Nacional	NNP
cord-001835-0s7ok4uw	1466	8	de	de	NNP
cord-001835-0s7ok4uw	1466	9	Biotecnolog	Biotecnolog	NNP
cord-001835-0s7ok4uw	1466	10	ıa	ıa	.
cord-001835-0s7ok4uw	1466	11	(	(	-LRB-
cord-001835-0s7ok4uw	1466	12	CNB	CNB	NNP
cord-001835-0s7ok4uw	1466	13	/	/	SYM
cord-001835-0s7ok4uw	1466	14	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	1466	15	)	)	-RRB-
cord-001835-0s7ok4uw	1466	16	.	.	.
cord-001835-0s7ok4uw	1467	1	,	,	,
cord-001835-0s7ok4uw	1467	2	2	2	CD
cord-001835-0s7ok4uw	1467	3	Centro	Centro	NNP
cord-001835-0s7ok4uw	1467	4	Nacional	Nacional	NNP
cord-001835-0s7ok4uw	1467	5	de	de	NNP
cord-001835-0s7ok4uw	1467	6	Biotecnolog	Biotecnolog	NNP
cord-001835-0s7ok4uw	1467	7	ıa	ıa	.
cord-001835-0s7ok4uw	1467	8	(	(	-LRB-
cord-001835-0s7ok4uw	1467	9	CNB	CNB	NNP
cord-001835-0s7ok4uw	1467	10	/	/	SYM
cord-001835-0s7ok4uw	1467	11	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	1467	12	)	)	-RRB-
cord-001835-0s7ok4uw	1467	13	.	.	.
cord-001835-0s7ok4uw	1468	1	,	,	,
cord-001835-0s7ok4uw	1468	2	3	3	CD
cord-001835-0s7ok4uw	1468	3	Centro	Centro	NNP
cord-001835-0s7ok4uw	1468	4	Nacional	Nacional	NNP
cord-001835-0s7ok4uw	1468	5	de	de	NNP
cord-001835-0s7ok4uw	1468	6	Biotecnolog	Biotecnolog	NNP
cord-001835-0s7ok4uw	1468	7	ıa	ıa	.
cord-001835-0s7ok4uw	1468	8	(	(	-LRB-
cord-001835-0s7ok4uw	1468	9	CNB	CNB	NNP
cord-001835-0s7ok4uw	1468	10	/	/	SYM
cord-001835-0s7ok4uw	1468	11	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	1468	12	)	)	-RRB-
cord-001835-0s7ok4uw	1468	13	.	.	.
cord-001835-0s7ok4uw	1469	1	,	,	,
cord-001835-0s7ok4uw	1469	2	4	4	CD
cord-001835-0s7ok4uw	1469	3	Centro	Centro	NNP
cord-001835-0s7ok4uw	1469	4	Nacional	Nacional	NNP
cord-001835-0s7ok4uw	1469	5	de	de	NNP
cord-001835-0s7ok4uw	1469	6	Biotecnolog	Biotecnolog	NNP
cord-001835-0s7ok4uw	1469	7	ıa	ıa	.
cord-001835-0s7ok4uw	1469	8	(	(	-LRB-
cord-001835-0s7ok4uw	1469	9	CNB	CNB	NNP
cord-001835-0s7ok4uw	1469	10	/	/	SYM
cord-001835-0s7ok4uw	1469	11	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	1469	12	)	)	-RRB-
cord-001835-0s7ok4uw	1469	13	and	and	CC
cord-001835-0s7ok4uw	1469	14	Fundaci	Fundaci	NNP
cord-001835-0s7ok4uw	1469	15	on	on	IN
cord-001835-0s7ok4uw	1469	16	IMDEA	IMDEA	NNP
cord-001835-0s7ok4uw	1469	17	-	-	HYPH
cord-001835-0s7ok4uw	1469	18	Nanociencia	Nanociencia	NNP
cord-001835-0s7ok4uw	1469	19	CCT	CCT	NNP
cord-001835-0s7ok4uw	1469	20	is	be	VBZ
cord-001835-0s7ok4uw	1469	21	a	a	DT
cord-001835-0s7ok4uw	1469	22	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	1469	23	chaperonin	chaperonin	NNS
cord-001835-0s7ok4uw	1469	24	that	that	WDT
cord-001835-0s7ok4uw	1469	25	uses	use	VBZ
cord-001835-0s7ok4uw	1469	26	ATP	ATP	NNP
cord-001835-0s7ok4uw	1469	27	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	1469	28	to	to	TO
cord-001835-0s7ok4uw	1469	29	encapsulate	encapsulate	VB
cord-001835-0s7ok4uw	1469	30	and	and	CC
cord-001835-0s7ok4uw	1469	31	fold	fold	VB
cord-001835-0s7ok4uw	1469	32	nascent	nascent	JJ
cord-001835-0s7ok4uw	1469	33	protein	protein	NN
cord-001835-0s7ok4uw	1469	34	chains	chain	NNS
cord-001835-0s7ok4uw	1469	35	.	.	.
cord-001835-0s7ok4uw	1470	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	1470	2	,	,	,
cord-001835-0s7ok4uw	1470	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	1470	4	has	have	VBZ
cord-001835-0s7ok4uw	1470	5	recently	recently	RB
cord-001835-0s7ok4uw	1470	6	been	be	VBN
cord-001835-0s7ok4uw	1470	7	shown	show	VBN
cord-001835-0s7ok4uw	1470	8	that	that	IN
cord-001835-0s7ok4uw	1470	9	CCT	CCT	NNP
cord-001835-0s7ok4uw	1470	10	is	be	VBZ
cord-001835-0s7ok4uw	1470	11	able	able	JJ
cord-001835-0s7ok4uw	1470	12	to	to	TO
cord-001835-0s7ok4uw	1470	13	inhibit	inhibit	VB
cord-001835-0s7ok4uw	1470	14	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1470	15	fibers	fiber	NNS
cord-001835-0s7ok4uw	1470	16	assembly	assembly	NN
cord-001835-0s7ok4uw	1470	17	and	and	CC
cord-001835-0s7ok4uw	1470	18	toxicity	toxicity	NN
cord-001835-0s7ok4uw	1470	19	of	of	IN
cord-001835-0s7ok4uw	1470	20	the	the	DT
cord-001835-0s7ok4uw	1470	21	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	1470	22	extended	extend	VBN
cord-001835-0s7ok4uw	1470	23	mutant	mutant	NN
cord-001835-0s7ok4uw	1470	24	of	of	IN
cord-001835-0s7ok4uw	1470	25	Huntingtin	Huntingtin	NNP
cord-001835-0s7ok4uw	1470	26	,	,	,
cord-001835-0s7ok4uw	1470	27	the	the	DT
cord-001835-0s7ok4uw	1470	28	protein	protein	NN
cord-001835-0s7ok4uw	1470	29	responsible	responsible	JJ
cord-001835-0s7ok4uw	1470	30	of	of	IN
cord-001835-0s7ok4uw	1470	31	Huntington	Huntington	NNP
cord-001835-0s7ok4uw	1470	32	disease	disease	NN
cord-001835-0s7ok4uw	1470	33	.	.	.
cord-001835-0s7ok4uw	1471	1	Although	although	IN
cord-001835-0s7ok4uw	1471	2	this	this	DT
cord-001835-0s7ok4uw	1471	3	opens	open	VBZ
cord-001835-0s7ok4uw	1471	4	the	the	DT
cord-001835-0s7ok4uw	1471	5	possibility	possibility	NN
cord-001835-0s7ok4uw	1471	6	of	of	IN
cord-001835-0s7ok4uw	1471	7	CCT	CCT	NNP
cord-001835-0s7ok4uw	1471	8	being	be	VBG
cord-001835-0s7ok4uw	1471	9	also	also	RB
cord-001835-0s7ok4uw	1471	10	able	able	JJ
cord-001835-0s7ok4uw	1471	11	to	to	TO
cord-001835-0s7ok4uw	1471	12	modulate	modulate	VB
cord-001835-0s7ok4uw	1471	13	other	other	JJ
cord-001835-0s7ok4uw	1471	14	amyloidopathies	amyloidopathie	NNS
cord-001835-0s7ok4uw	1471	15	,	,	,
cord-001835-0s7ok4uw	1471	16	this	this	DT
cord-001835-0s7ok4uw	1471	17	has	have	VBZ
cord-001835-0s7ok4uw	1471	18	not	not	RB
cord-001835-0s7ok4uw	1471	19	addressed	address	VBN
cord-001835-0s7ok4uw	1471	20	yet	yet	RB
cord-001835-0s7ok4uw	1471	21	.	.	.
cord-001835-0s7ok4uw	1472	1	The	the	DT
cord-001835-0s7ok4uw	1472	2	work	work	NN
cord-001835-0s7ok4uw	1472	3	presented	present	VBN
cord-001835-0s7ok4uw	1472	4	here	here	RB
cord-001835-0s7ok4uw	1472	5	intends	intend	VBZ
cord-001835-0s7ok4uw	1472	6	to	to	TO
cord-001835-0s7ok4uw	1472	7	determine	determine	VB
cord-001835-0s7ok4uw	1472	8	the	the	DT
cord-001835-0s7ok4uw	1472	9	effect	effect	NN
cord-001835-0s7ok4uw	1472	10	of	of	IN
cord-001835-0s7ok4uw	1472	11	CCT	CCT	NNP
cord-001835-0s7ok4uw	1472	12	in	in	IN
cord-001835-0s7ok4uw	1472	13	the	the	DT
cord-001835-0s7ok4uw	1472	14	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1472	15	fibers	fiber	NNS
cord-001835-0s7ok4uw	1472	16	assembly	assembly	NN
cord-001835-0s7ok4uw	1472	17	of	of	IN
cord-001835-0s7ok4uw	1472	18	a	a	DT
cord-001835-0s7ok4uw	1472	19	-	-	HYPH
cord-001835-0s7ok4uw	1472	20	Synuclein(A53	Synuclein(A53	NNP
cord-001835-0s7ok4uw	1472	21	T	T	NNP
cord-001835-0s7ok4uw	1472	22	)	)	-RRB-
cord-001835-0s7ok4uw	1472	23	,	,	,
cord-001835-0s7ok4uw	1472	24	one	one	CD
cord-001835-0s7ok4uw	1472	25	of	of	IN
cord-001835-0s7ok4uw	1472	26	the	the	DT
cord-001835-0s7ok4uw	1472	27	mutants	mutant	NNS
cord-001835-0s7ok4uw	1472	28	responsible	responsible	JJ
cord-001835-0s7ok4uw	1472	29	of	of	IN
cord-001835-0s7ok4uw	1472	30	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	1472	31	disease	disease	NN
cord-001835-0s7ok4uw	1472	32	.	.	.
cord-001835-0s7ok4uw	1473	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1473	2	is	be	VBZ
cord-001835-0s7ok4uw	1473	3	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	1473	4	that	that	IN
cord-001835-0s7ok4uw	1473	5	CCT	CCT	NNP
cord-001835-0s7ok4uw	1473	6	is	be	VBZ
cord-001835-0s7ok4uw	1473	7	able	able	JJ
cord-001835-0s7ok4uw	1473	8	to	to	TO
cord-001835-0s7ok4uw	1473	9	inhibit	inhibit	VB
cord-001835-0s7ok4uw	1473	10	a	a	DT
cord-001835-0s7ok4uw	1473	11	-	-	HYPH
cord-001835-0s7ok4uw	1473	12	Synuclein(A53	Synuclein(A53	NNP
cord-001835-0s7ok4uw	1473	13	T	t	NN
cord-001835-0s7ok4uw	1473	14	)	)	-RRB-
cord-001835-0s7ok4uw	1473	15	fibrillation	fibrillation	NN
cord-001835-0s7ok4uw	1473	16	in	in	IN
cord-001835-0s7ok4uw	1473	17	a	a	DT
cord-001835-0s7ok4uw	1473	18	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	1473	19	independent	independent	JJ
cord-001835-0s7ok4uw	1473	20	way	way	NN
cord-001835-0s7ok4uw	1473	21	,	,	,
cord-001835-0s7ok4uw	1473	22	suggesting	suggest	VBG
cord-001835-0s7ok4uw	1473	23	that	that	IN
cord-001835-0s7ok4uw	1473	24	this	this	DT
cord-001835-0s7ok4uw	1473	25	effect	effect	NN
cord-001835-0s7ok4uw	1473	26	is	be	VBZ
cord-001835-0s7ok4uw	1473	27	based	base	VBN
cord-001835-0s7ok4uw	1473	28	on	on	IN
cord-001835-0s7ok4uw	1473	29	binding	bind	VBG
cord-001835-0s7ok4uw	1473	30	rather	rather	RB
cord-001835-0s7ok4uw	1473	31	than	than	IN
cord-001835-0s7ok4uw	1473	32	on	on	IN
cord-001835-0s7ok4uw	1473	33	active	active	JJ
cord-001835-0s7ok4uw	1473	34	folding	folding	NN
cord-001835-0s7ok4uw	1473	35	.	.	.
cord-001835-0s7ok4uw	1474	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1474	2	,	,	,
cord-001835-0s7ok4uw	1474	3	using	use	VBG
cord-001835-0s7ok4uw	1474	4	deletion	deletion	NN
cord-001835-0s7ok4uw	1474	5	mutants	mutant	NNS
cord-001835-0s7ok4uw	1474	6	and	and	CC
cord-001835-0s7ok4uw	1474	7	assaying	assay	VBG
cord-001835-0s7ok4uw	1474	8	the	the	DT
cord-001835-0s7ok4uw	1474	9	interaction	interaction	NN
cord-001835-0s7ok4uw	1474	10	of	of	IN
cord-001835-0s7ok4uw	1474	11	CCT	CCT	NNP
cord-001835-0s7ok4uw	1474	12	with	with	IN
cord-001835-0s7ok4uw	1474	13	monomers	monomer	NNS
cord-001835-0s7ok4uw	1474	14	,	,	,
cord-001835-0s7ok4uw	1474	15	soluble	soluble	JJ
cord-001835-0s7ok4uw	1474	16	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	1474	17	and	and	CC
cord-001835-0s7ok4uw	1474	18	fibres	fibre	NNS
cord-001835-0s7ok4uw	1474	19	,	,	,
cord-001835-0s7ok4uw	1474	20	it	-PRON-	PRP
cord-001835-0s7ok4uw	1474	21	has	have	VBZ
cord-001835-0s7ok4uw	1474	22	been	be	VBN
cord-001835-0s7ok4uw	1474	23	possible	possible	JJ
cord-001835-0s7ok4uw	1474	24	to	to	TO
cord-001835-0s7ok4uw	1474	25	unravel	unravel	VB
cord-001835-0s7ok4uw	1474	26	the	the	DT
cord-001835-0s7ok4uw	1474	27	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1474	28	of	of	IN
cord-001835-0s7ok4uw	1474	29	this	this	DT
cord-001835-0s7ok4uw	1474	30	inhibition	inhibition	NN
cord-001835-0s7ok4uw	1474	31	:	:	:
cord-001835-0s7ok4uw	1474	32	CCT	CCT	NNP
cord-001835-0s7ok4uw	1474	33	interferes	interfere	VBZ
cord-001835-0s7ok4uw	1474	34	with	with	IN
cord-001835-0s7ok4uw	1474	35	fibers	fiber	NNS
cord-001835-0s7ok4uw	1474	36	assembly	assembly	NN
cord-001835-0s7ok4uw	1474	37	by	by	IN
cord-001835-0s7ok4uw	1474	38	interacting	interact	VBG
cord-001835-0s7ok4uw	1474	39	with	with	IN
cord-001835-0s7ok4uw	1474	40	a	a	DT
cord-001835-0s7ok4uw	1474	41	-	-	HYPH
cord-001835-0s7ok4uw	1474	42	Synuclein(A53	Synuclein(A53	NNP
cord-001835-0s7ok4uw	1474	43	T	t	NN
cord-001835-0s7ok4uw	1474	44	)	)	-RRB-
cord-001835-0s7ok4uw	1474	45	NAC	NAC	NNP
cord-001835-0s7ok4uw	1474	46	domain	domain	NN
cord-001835-0s7ok4uw	1474	47	once	once	IN
cord-001835-0s7ok4uw	1474	48	soluble	soluble	JJ
cord-001835-0s7ok4uw	1474	49	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	1474	50	are	be	VBP
cord-001835-0s7ok4uw	1474	51	formed	form	VBN
cord-001835-0s7ok4uw	1474	52	,	,	,
cord-001835-0s7ok4uw	1474	53	thus	thus	RB
cord-001835-0s7ok4uw	1474	54	blocking	block	VBG
cord-001835-0s7ok4uw	1474	55	the	the	DT
cord-001835-0s7ok4uw	1474	56	reaction	reaction	NN
cord-001835-0s7ok4uw	1474	57	before	before	IN
cord-001835-0s7ok4uw	1474	58	the	the	DT
cord-001835-0s7ok4uw	1474	59	fibers	fiber	NNS
cord-001835-0s7ok4uw	1474	60	start	start	VBP
cord-001835-0s7ok4uw	1474	61	to	to	TO
cord-001835-0s7ok4uw	1474	62	grow	grow	VB
cord-001835-0s7ok4uw	1474	63	.	.	.
cord-001835-0s7ok4uw	1475	1	Amyloid	amyloid	NN
cord-001835-0s7ok4uw	1475	2	-	-	HYPH
cord-001835-0s7ok4uw	1475	3	like	like	JJ
cord-001835-0s7ok4uw	1475	4	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1475	5	of	of	IN
cord-001835-0s7ok4uw	1475	6	Nucleophosmin	Nucleophosmin	NNP
cord-001835-0s7ok4uw	1475	7	regions	region	NNS
cord-001835-0s7ok4uw	1475	8	associated	associate	VBN
cord-001835-0s7ok4uw	1475	9	with	with	IN
cord-001835-0s7ok4uw	1475	10	acute	acute	JJ
cord-001835-0s7ok4uw	1475	11	myeloid	myeloid	JJ
cord-001835-0s7ok4uw	1475	12	leukemia	leukemia	NN
cord-001835-0s7ok4uw	1475	13	mutations	mutation	NNS
cord-001835-0s7ok4uw	1475	14	Daniela	Daniela	NNP
cord-001835-0s7ok4uw	1475	15	Marasco	Marasco	NNP
cord-001835-0s7ok4uw	1475	16	1	1	CD
cord-001835-0s7ok4uw	1475	17	,	,	,
cord-001835-0s7ok4uw	1475	18	Concetta	Concetta	NNP
cord-001835-0s7ok4uw	1475	19	Di	Di	NNP
cord-001835-0s7ok4uw	1475	20	Natale	Natale	NNP
cord-001835-0s7ok4uw	1475	21	1	1	CD
cord-001835-0s7ok4uw	1475	22	,	,	,
cord-001835-0s7ok4uw	1475	23	Valentina	Valentina	NNP
cord-001835-0s7ok4uw	1475	24	Punzo	Punzo	NNP
cord-001835-0s7ok4uw	1475	25	1	1	CD
cord-001835-0s7ok4uw	1475	26	,	,	,
cord-001835-0s7ok4uw	1475	27	Domenico	Domenico	NNP
cord-001835-0s7ok4uw	1475	28	Riccardi	Riccardi	NNPS
cord-001835-0s7ok4uw	1475	29	1	1	CD
cord-001835-0s7ok4uw	1475	30	,	,	,
cord-001835-0s7ok4uw	1475	31	Pasqualina	Pasqualina	NNP
cord-001835-0s7ok4uw	1475	32	Scognamiglio	Scognamiglio	NNP
cord-001835-0s7ok4uw	1475	33	1	1	CD
cord-001835-0s7ok4uw	1475	34	,	,	,
cord-001835-0s7ok4uw	1475	35	Roberta	Roberta	NNP
cord-001835-0s7ok4uw	1475	36	Cascella	Cascella	NNP
cord-001835-0s7ok4uw	1475	37	2	2	CD
cord-001835-0s7ok4uw	1475	38	,	,	,
cord-001835-0s7ok4uw	1475	39	Cristina	Cristina	NNP
cord-001835-0s7ok4uw	1475	40	Cecchi	Cecchi	NNP
cord-001835-0s7ok4uw	1475	41	2	2	CD
cord-001835-0s7ok4uw	1475	42	,	,	,
cord-001835-0s7ok4uw	1475	43	Fabrizio	Fabrizio	NNP
cord-001835-0s7ok4uw	1475	44	Chiti	Chiti	NNP
cord-001835-0s7ok4uw	1475	45	2	2	CD
cord-001835-0s7ok4uw	1475	46	,	,	,
cord-001835-0s7ok4uw	1475	47	Marilisa	Marilisa	NNP
cord-001835-0s7ok4uw	1475	48	Leone	Leone	NNP
cord-001835-0s7ok4uw	1475	49	3	3	CD
cord-001835-0s7ok4uw	1475	50	,	,	,
cord-001835-0s7ok4uw	1475	51	Luigi	Luigi	NNP
cord-001835-0s7ok4uw	1475	52	Vitagliano	Vitagliano	NNP
cord-001835-0s7ok4uw	1475	53	3	3	CD
cord-001835-0s7ok4uw	1475	54	1	1	CD
cord-001835-0s7ok4uw	1475	55	Department	Department	NNP
cord-001835-0s7ok4uw	1475	56	of	of	IN
cord-001835-0s7ok4uw	1475	57	Pharmacy	Pharmacy	NNP
cord-001835-0s7ok4uw	1475	58	,	,	,
cord-001835-0s7ok4uw	1475	59	CIRPEB	CIRPEB	NNP
cord-001835-0s7ok4uw	1475	60	:	:	:
cord-001835-0s7ok4uw	1476	1	Centro	Centro	NNP
cord-001835-0s7ok4uw	1476	2	Interuniversitario	Interuniversitario	NNP
cord-001835-0s7ok4uw	1476	3	di	di	NNP
cord-001835-0s7ok4uw	1476	4	Ricerca	Ricerca	NNP
cord-001835-0s7ok4uw	1476	5	sui	sui	NN
cord-001835-0s7ok4uw	1476	6	Pepti	Pepti	NNP
cord-001835-0s7ok4uw	1476	7	,	,	,
cord-001835-0s7ok4uw	1476	8	2	2	CD
cord-001835-0s7ok4uw	1476	9	Section	section	NN
cord-001835-0s7ok4uw	1476	10	of	of	IN
cord-001835-0s7ok4uw	1476	11	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	1476	12	,	,	,
cord-001835-0s7ok4uw	1476	13	Department	Department	NNP
cord-001835-0s7ok4uw	1476	14	of	of	IN
cord-001835-0s7ok4uw	1476	15	Biomedical	Biomedical	NNP
cord-001835-0s7ok4uw	1476	16	Experimental	Experimental	NNP
cord-001835-0s7ok4uw	1476	17	and	and	CC
cord-001835-0s7ok4uw	1476	18	Clinical	Clinical	NNP
cord-001835-0s7ok4uw	1476	19	Scie	Scie	NNP
cord-001835-0s7ok4uw	1476	20	,	,	,
cord-001835-0s7ok4uw	1476	21	3	3	CD
cord-001835-0s7ok4uw	1476	22	Institute	Institute	NNP
cord-001835-0s7ok4uw	1476	23	of	of	IN
cord-001835-0s7ok4uw	1476	24	Biostructures	Biostructures	NNP
cord-001835-0s7ok4uw	1476	25	and	and	CC
cord-001835-0s7ok4uw	1476	26	Bioimaging	Bioimaging	NNP
cord-001835-0s7ok4uw	1476	27	Nucleophosmin	Nucleophosmin	NNP
cord-001835-0s7ok4uw	1477	1	(	(	-LRB-
cord-001835-0s7ok4uw	1477	2	NPM1	NPM1	NNP
cord-001835-0s7ok4uw	1477	3	)	)	-RRB-
cord-001835-0s7ok4uw	1477	4	is	be	VBZ
cord-001835-0s7ok4uw	1477	5	a	a	DT
cord-001835-0s7ok4uw	1477	6	multifunctional	multifunctional	JJ
cord-001835-0s7ok4uw	1477	7	protein	protein	NN
cord-001835-0s7ok4uw	1477	8	involved	involve	VBN
cord-001835-0s7ok4uw	1477	9	in	in	IN
cord-001835-0s7ok4uw	1477	10	a	a	DT
cord-001835-0s7ok4uw	1477	11	variety	variety	NN
cord-001835-0s7ok4uw	1477	12	of	of	IN
cord-001835-0s7ok4uw	1477	13	biological	biological	JJ
cord-001835-0s7ok4uw	1477	14	processes	process	NNS
cord-001835-0s7ok4uw	1477	15	and	and	CC
cord-001835-0s7ok4uw	1477	16	implicated	implicate	VBN
cord-001835-0s7ok4uw	1477	17	in	in	IN
cord-001835-0s7ok4uw	1477	18	the	the	DT
cord-001835-0s7ok4uw	1477	19	pathogenesis	pathogenesis	NN
cord-001835-0s7ok4uw	1477	20	of	of	IN
cord-001835-0s7ok4uw	1477	21	several	several	JJ
cord-001835-0s7ok4uw	1477	22	human	human	JJ
cord-001835-0s7ok4uw	1477	23	malignancies	malignancy	NNS
cord-001835-0s7ok4uw	1477	24	.	.	.
cord-001835-0s7ok4uw	1478	1	NPM1	NPM1	NNP
cord-001835-0s7ok4uw	1478	2	has	have	VBZ
cord-001835-0s7ok4uw	1478	3	been	be	VBN
cord-001835-0s7ok4uw	1478	4	identified	identify	VBN
cord-001835-0s7ok4uw	1478	5	as	as	IN
cord-001835-0s7ok4uw	1478	6	the	the	DT
cord-001835-0s7ok4uw	1478	7	most	most	RBS
cord-001835-0s7ok4uw	1478	8	frequently	frequently	RB
cord-001835-0s7ok4uw	1478	9	mutated	mutate	VBN
cord-001835-0s7ok4uw	1478	10	gene	gene	NN
cord-001835-0s7ok4uw	1478	11	in	in	IN
cord-001835-0s7ok4uw	1478	12	acute	acute	JJ
cord-001835-0s7ok4uw	1478	13	myeloid	myeloid	NN
cord-001835-0s7ok4uw	1478	14	leukemia	leukemia	NN
cord-001835-0s7ok4uw	1478	15	(	(	-LRB-
cord-001835-0s7ok4uw	1478	16	AML	AML	NNP
cord-001835-0s7ok4uw	1478	17	)	)	-RRB-
cord-001835-0s7ok4uw	1478	18	patients	patient	NNS
cord-001835-0s7ok4uw	1478	19	,	,	,
cord-001835-0s7ok4uw	1478	20	accounting	account	VBG
cord-001835-0s7ok4uw	1478	21	for	for	IN
cord-001835-0s7ok4uw	1478	22	approximately	approximately	RB
cord-001835-0s7ok4uw	1478	23	30	30	CD
cord-001835-0s7ok4uw	1478	24	%	%	NN
cord-001835-0s7ok4uw	1478	25	of	of	IN
cord-001835-0s7ok4uw	1478	26	cases	case	NNS
cord-001835-0s7ok4uw	1478	27	(	(	-LRB-
cord-001835-0s7ok4uw	1478	28	1	1	CD
cord-001835-0s7ok4uw	1478	29	)	)	-RRB-
cord-001835-0s7ok4uw	1478	30	.	.	.
cord-001835-0s7ok4uw	1479	1	The	the	DT
cord-001835-0s7ok4uw	1479	2	most	most	RBS
cord-001835-0s7ok4uw	1479	3	frequent	frequent	JJ
cord-001835-0s7ok4uw	1479	4	human	human	JJ
cord-001835-0s7ok4uw	1479	5	NPM1	NPM1	NNP
cord-001835-0s7ok4uw	1479	6	mutations	mutation	NNS
cord-001835-0s7ok4uw	1479	7	lead	lead	VBP
cord-001835-0s7ok4uw	1479	8	to	to	IN
cord-001835-0s7ok4uw	1479	9	variants	variant	NNS
cord-001835-0s7ok4uw	1479	10	with	with	IN
cord-001835-0s7ok4uw	1479	11	altered	alter	VBN
cord-001835-0s7ok4uw	1479	12	C	c	NN
cord-001835-0s7ok4uw	1479	13	-	-	HYPH
cord-001835-0s7ok4uw	1479	14	terminal	terminal	NN
cord-001835-0s7ok4uw	1479	15	sequences	sequence	NNS
cord-001835-0s7ok4uw	1479	16	of	of	IN
cord-001835-0s7ok4uw	1479	17	the	the	DT
cord-001835-0s7ok4uw	1479	18	C	C	NNP
cord-001835-0s7ok4uw	1479	19	-	-	HYPH
cord-001835-0s7ok4uw	1479	20	Terminal	Terminal	NNP
cord-001835-0s7ok4uw	1479	21	Domain	Domain	NNP
cord-001835-0s7ok4uw	1479	22	(	(	-LRB-
cord-001835-0s7ok4uw	1479	23	CTD	CTD	NNP
cord-001835-0s7ok4uw	1479	24	)	)	-RRB-
cord-001835-0s7ok4uw	1479	25	that	that	IN
cord-001835-0s7ok4uw	1479	26	,	,	,
cord-001835-0s7ok4uw	1479	27	in	in	IN
cord-001835-0s7ok4uw	1479	28	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1479	29	wild	wild	JJ
cord-001835-0s7ok4uw	1479	30	form	form	NN
cord-001835-0s7ok4uw	1479	31	,	,	,
cord-001835-0s7ok4uw	1479	32	folds	fold	VBZ
cord-001835-0s7ok4uw	1479	33	as	as	IN
cord-001835-0s7ok4uw	1479	34	a	a	DT
cord-001835-0s7ok4uw	1479	35	three	three	CD
cord-001835-0s7ok4uw	1479	36	helix	helix	NN
cord-001835-0s7ok4uw	1479	37	bundle	bundle	NN
cord-001835-0s7ok4uw	1479	38	.	.	.
cord-001835-0s7ok4uw	1480	1	AML	AML	NNP
cord-001835-0s7ok4uw	1480	2	modifications	modification	NNS
cord-001835-0s7ok4uw	1480	3	lead	lead	VBP
cord-001835-0s7ok4uw	1480	4	to	to	IN
cord-001835-0s7ok4uw	1480	5	(	(	-LRB-
cord-001835-0s7ok4uw	1480	6	a	a	LS
cord-001835-0s7ok4uw	1480	7	)	)	-RRB-
cord-001835-0s7ok4uw	1480	8	an	an	DT
cord-001835-0s7ok4uw	1480	9	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1480	10	of	of	IN
cord-001835-0s7ok4uw	1480	11	the	the	DT
cord-001835-0s7ok4uw	1480	12	CTD	CTD	NNP
cord-001835-0s7ok4uw	1480	13	in	in	IN
cord-001835-0s7ok4uw	1480	14	the	the	DT
cord-001835-0s7ok4uw	1480	15	mutated	mutate	VBN
cord-001835-0s7ok4uw	1480	16	protein	protein	NN
cord-001835-0s7ok4uw	1480	17	and	and	CC
cord-001835-0s7ok4uw	1480	18	(	(	-LRB-
cord-001835-0s7ok4uw	1480	19	b	b	NN
cord-001835-0s7ok4uw	1480	20	)	)	-RRB-
cord-001835-0s7ok4uw	1480	21	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1480	22	accumulation	accumulation	NN
cord-001835-0s7ok4uw	1480	23	in	in	IN
cord-001835-0s7ok4uw	1480	24	the	the	DT
cord-001835-0s7ok4uw	1480	25	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	1480	26	due	due	IN
cord-001835-0s7ok4uw	1480	27	to	to	IN
cord-001835-0s7ok4uw	1480	28	the	the	DT
cord-001835-0s7ok4uw	1480	29	loss	loss	NN
cord-001835-0s7ok4uw	1480	30	of	of	IN
cord-001835-0s7ok4uw	1480	31	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	1480	32	localization	localization	NN
cord-001835-0s7ok4uw	1480	33	sequences	sequence	NNS
cord-001835-0s7ok4uw	1480	34	with	with	IN
cord-001835-0s7ok4uw	1480	35	mutations	mutation	NNS
cord-001835-0s7ok4uw	1480	36	of	of	IN
cord-001835-0s7ok4uw	1480	37	Trp290	Trp290	NNP
cord-001835-0s7ok4uw	1480	38	(	(	-LRB-
cord-001835-0s7ok4uw	1480	39	mut	mut	NNP
cord-001835-0s7ok4uw	1480	40	E	E	NNP
cord-001835-0s7ok4uw	1480	41	)	)	-RRB-
cord-001835-0s7ok4uw	1480	42	and	and	CC
cord-001835-0s7ok4uw	1480	43	also	also	RB
cord-001835-0s7ok4uw	1480	44	of	of	IN
cord-001835-0s7ok4uw	1480	45	Trp288	trp288	LS
cord-001835-0s7ok4uw	1480	46	(	(	-LRB-
cord-001835-0s7ok4uw	1480	47	mut	mut	NNP
cord-001835-0s7ok4uw	1480	48	A	A	NNP
cord-001835-0s7ok4uw	1480	49	)	)	-RRB-
cord-001835-0s7ok4uw	1480	50	(	(	-LRB-
cord-001835-0s7ok4uw	1480	51	2	2	CD
cord-001835-0s7ok4uw	1480	52	)	)	-RRB-
cord-001835-0s7ok4uw	1480	53	.	.	.
cord-001835-0s7ok4uw	1481	1	To	to	TO
cord-001835-0s7ok4uw	1481	2	gain	gain	VB
cord-001835-0s7ok4uw	1481	3	insights	insight	NNS
cord-001835-0s7ok4uw	1481	4	into	into	IN
cord-001835-0s7ok4uw	1481	5	the	the	DT
cord-001835-0s7ok4uw	1481	6	role	role	NN
cord-001835-0s7ok4uw	1481	7	of	of	IN
cord-001835-0s7ok4uw	1481	8	isolated	isolated	JJ
cord-001835-0s7ok4uw	1481	9	fragments	fragment	NNS
cord-001835-0s7ok4uw	1481	10	in	in	IN
cord-001835-0s7ok4uw	1481	11	NPM1	NPM1	NNP
cord-001835-0s7ok4uw	1481	12	activities	activity	NNS
cord-001835-0s7ok4uw	1481	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	1481	14	dissected	dissect	VBD
cord-001835-0s7ok4uw	1481	15	the	the	DT
cord-001835-0s7ok4uw	1481	16	CTD	CTD	NNP
cord-001835-0s7ok4uw	1481	17	in	in	IN
cord-001835-0s7ok4uw	1481	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1481	19	helical	helical	JJ
cord-001835-0s7ok4uw	1481	20	fragments	fragment	NNS
cord-001835-0s7ok4uw	1481	21	.	.	.
cord-001835-0s7ok4uw	1482	1	Here	here	RB
cord-001835-0s7ok4uw	1482	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	1482	3	describe	describe	VBP
cord-001835-0s7ok4uw	1482	4	the	the	DT
cord-001835-0s7ok4uw	1482	5	unexpected	unexpected	JJ
cord-001835-0s7ok4uw	1482	6	structural	structural	JJ
cord-001835-0s7ok4uw	1482	7	behavior	behavior	NN
cord-001835-0s7ok4uw	1482	8	of	of	IN
cord-001835-0s7ok4uw	1482	9	the	the	DT
cord-001835-0s7ok4uw	1482	10	fragments	fragment	NNS
cord-001835-0s7ok4uw	1482	11	corresponding	correspond	VBG
cord-001835-0s7ok4uw	1482	12	to	to	IN
cord-001835-0s7ok4uw	1482	13	the	the	DT
cord-001835-0s7ok4uw	1482	14	helices	helix	NNS
cord-001835-0s7ok4uw	1482	15	H2	H2	NNP
cord-001835-0s7ok4uw	1482	16	and	and	CC
cord-001835-0s7ok4uw	1482	17	H3	H3	NNP
cord-001835-0s7ok4uw	1482	18	in	in	IN
cord-001835-0s7ok4uw	1482	19	both	both	DT
cord-001835-0s7ok4uw	1482	20	wild	wild	JJ
cord-001835-0s7ok4uw	1482	21	-	-	HYPH
cord-001835-0s7ok4uw	1482	22	type	type	NN
cord-001835-0s7ok4uw	1482	23	and	and	CC
cord-001835-0s7ok4uw	1482	24	AML	aml	NN
cord-001835-0s7ok4uw	1482	25	-	-	HYPH
cord-001835-0s7ok4uw	1482	26	mutated	mutate	VBN
cord-001835-0s7ok4uw	1482	27	variants	variant	NNS
cord-001835-0s7ok4uw	1482	28	.	.	.
cord-001835-0s7ok4uw	1483	1	H2	H2	NNP
cord-001835-0s7ok4uw	1483	2	region	region	NN
cord-001835-0s7ok4uw	1483	3	shows	show	VBZ
cord-001835-0s7ok4uw	1483	4	a	a	DT
cord-001835-0s7ok4uw	1483	5	remarkable	remarkable	JJ
cord-001835-0s7ok4uw	1483	6	tendency	tendency	NN
cord-001835-0s7ok4uw	1483	7	to	to	TO
cord-001835-0s7ok4uw	1483	8	form	form	VB
cord-001835-0s7ok4uw	1483	9	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1483	10	-	-	HYPH
cord-001835-0s7ok4uw	1483	11	like	like	JJ
cord-001835-0s7ok4uw	1483	12	assemblies	assembly	NNS
cord-001835-0s7ok4uw	1483	13	while	while	IN
cord-001835-0s7ok4uw	1483	14	only	only	RB
cord-001835-0s7ok4uw	1483	15	the	the	DT
cord-001835-0s7ok4uw	1483	16	MutA	MutA	NNP
cord-001835-0s7ok4uw	1483	17	sequence	sequence	NN
cord-001835-0s7ok4uw	1483	18	of	of	IN
cord-001835-0s7ok4uw	1483	19	H3	H3	NNP
cord-001835-0s7ok4uw	1483	20	region	region	NN
cord-001835-0s7ok4uw	1483	21	is	be	VBZ
cord-001835-0s7ok4uw	1483	22	endowed	endow	VBN
cord-001835-0s7ok4uw	1483	23	with	with	IN
cord-001835-0s7ok4uw	1483	24	and	and	CC
cord-001835-0s7ok4uw	1483	25	b	b	NN
cord-001835-0s7ok4uw	1483	26	-	-	HYPH
cord-001835-0s7ok4uw	1483	27	sheet	sheet	NN
cord-001835-0s7ok4uw	1483	28	structure	structure	NN
cord-001835-0s7ok4uw	1483	29	,	,	,
cord-001835-0s7ok4uw	1483	30	under	under	IN
cord-001835-0s7ok4uw	1483	31	physiological	physiological	JJ
cord-001835-0s7ok4uw	1483	32	conditions	condition	NNS
cord-001835-0s7ok4uw	1483	33	,	,	,
cord-001835-0s7ok4uw	1483	34	as	as	IN
cord-001835-0s7ok4uw	1483	35	shown	show	VBN
cord-001835-0s7ok4uw	1483	36	by	by	IN
cord-001835-0s7ok4uw	1483	37	circular	circular	JJ
cord-001835-0s7ok4uw	1483	38	dichroism	dichroism	NN
cord-001835-0s7ok4uw	1483	39	,	,	,
cord-001835-0s7ok4uw	1483	40	Thioflavin	Thioflavin	NNP
cord-001835-0s7ok4uw	1483	41	T	T	NNP
cord-001835-0s7ok4uw	1483	42	and	and	CC
cord-001835-0s7ok4uw	1483	43	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	1483	44	light	light	JJ
cord-001835-0s7ok4uw	1483	45	scattering	scattering	NN
cord-001835-0s7ok4uw	1483	46	.	.	.
cord-001835-0s7ok4uw	1484	1	The	the	DT
cord-001835-0s7ok4uw	1484	2	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	1484	3	of	of	IN
cord-001835-0s7ok4uw	1484	4	H2	H2	NNP
cord-001835-0s7ok4uw	1484	5	,	,	,
cord-001835-0s7ok4uw	1484	6	are	be	VBP
cord-001835-0s7ok4uw	1484	7	also	also	RB
cord-001835-0s7ok4uw	1484	8	toxic	toxic	JJ
cord-001835-0s7ok4uw	1484	9	to	to	IN
cord-001835-0s7ok4uw	1484	10	neuroblastoma	neuroblastoma	NN
cord-001835-0s7ok4uw	1484	11	cells	cell	NNS
cord-001835-0s7ok4uw	1484	12	,	,	,
cord-001835-0s7ok4uw	1484	13	as	as	IN
cord-001835-0s7ok4uw	1484	14	determined	determine	VBN
cord-001835-0s7ok4uw	1484	15	by	by	IN
cord-001835-0s7ok4uw	1484	16	using	use	VBG
cord-001835-0s7ok4uw	1484	17	the	the	DT
cord-001835-0s7ok4uw	1484	18	MTT	MTT	NNP
cord-001835-0s7ok4uw	1484	19	reduction	reduction	NN
cord-001835-0s7ok4uw	1484	20	and	and	CC
cord-001835-0s7ok4uw	1484	21	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	1485	1	influx	influx	JJ
cord-001835-0s7ok4uw	1485	2	assays	assay	NNS
cord-001835-0s7ok4uw	1485	3	(	(	-LRB-
cord-001835-0s7ok4uw	1485	4	3	3	CD
cord-001835-0s7ok4uw	1485	5	)	)	-RRB-
cord-001835-0s7ok4uw	1485	6	.	.	.
cord-001835-0s7ok4uw	1486	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1486	2	the	the	DT
cord-001835-0s7ok4uw	1486	3	effects	effect	NNS
cord-001835-0s7ok4uw	1486	4	of	of	IN
cord-001835-0s7ok4uw	1486	5	the	the	DT
cord-001835-0s7ok4uw	1486	6	local	local	JJ
cord-001835-0s7ok4uw	1486	7	context	context	NN
cord-001835-0s7ok4uw	1486	8	on	on	IN
cord-001835-0s7ok4uw	1486	9	the	the	DT
cord-001835-0s7ok4uw	1486	10	different	different	JJ
cord-001835-0s7ok4uw	1486	11	tendencies	tendency	NNS
cord-001835-0s7ok4uw	1486	12	to	to	TO
cord-001835-0s7ok4uw	1486	13	aggregate	aggregate	VB
cord-001835-0s7ok4uw	1486	14	of	of	IN
cord-001835-0s7ok4uw	1486	15	H2	H2	NNP
cord-001835-0s7ok4uw	1486	16	and	and	CC
cord-001835-0s7ok4uw	1486	17	H3	H3	NNP
cord-001835-0s7ok4uw	1486	18	were	be	VBD
cord-001835-0s7ok4uw	1486	19	investigated	investigate	VBN
cord-001835-0s7ok4uw	1486	20	and	and	CC
cord-001835-0s7ok4uw	1486	21	appeared	appear	VBD
cord-001835-0s7ok4uw	1486	22	to	to	TO
cord-001835-0s7ok4uw	1486	23	influence	influence	VB
cord-001835-0s7ok4uw	1486	24	for	for	IN
cord-001835-0s7ok4uw	1486	25	the	the	DT
cord-001835-0s7ok4uw	1486	26	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1486	27	propensity	propensity	NN
cord-001835-0s7ok4uw	1486	28	of	of	IN
cord-001835-0s7ok4uw	1486	29	the	the	DT
cord-001835-0s7ok4uw	1486	30	entire	entire	JJ
cord-001835-0s7ok4uw	1486	31	CTD	CTD	NNP
cord-001835-0s7ok4uw	1486	32	.	.	.
cord-001835-0s7ok4uw	1487	1	Since	since	IN
cord-001835-0s7ok4uw	1487	2	in	in	IN
cord-001835-0s7ok4uw	1487	3	AML	AML	NNP
cord-001835-0s7ok4uw	1487	4	mutants	mutant	NNS
cord-001835-0s7ok4uw	1487	5	the	the	DT
cord-001835-0s7ok4uw	1487	6	CTD	CTD	NNP
cord-001835-0s7ok4uw	1487	7	is	be	VBZ
cord-001835-0s7ok4uw	1487	8	not	not	RB
cord-001835-0s7ok4uw	1487	9	properly	properly	RB
cord-001835-0s7ok4uw	1487	10	folded	fold	VBN
cord-001835-0s7ok4uw	1487	11	,	,	,
cord-001835-0s7ok4uw	1487	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	1487	13	hypothesize	hypothesize	VBP
cord-001835-0s7ok4uw	1487	14	that	that	IN
cord-001835-0s7ok4uw	1487	15	the	the	DT
cord-001835-0s7ok4uw	1487	16	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1487	17	propensity	propensity	NN
cord-001835-0s7ok4uw	1487	18	of	of	IN
cord-001835-0s7ok4uw	1487	19	NPM1	NPM1	NNP
cord-001835-0s7ok4uw	1487	20	regions	region	NNS
cord-001835-0s7ok4uw	1487	21	may	may	MD
cord-001835-0s7ok4uw	1487	22	be	be	VB
cord-001835-0s7ok4uw	1487	23	implicated	implicate	VBN
cord-001835-0s7ok4uw	1487	24	in	in	IN
cord-001835-0s7ok4uw	1487	25	AML	AML	NNP
cord-001835-0s7ok4uw	1487	26	etiology	etiology	NN
cord-001835-0s7ok4uw	1487	27	.	.	.
cord-001835-0s7ok4uw	1488	1	These	these	DT
cord-001835-0s7ok4uw	1488	2	findings	finding	NNS
cord-001835-0s7ok4uw	1488	3	have	have	VBP
cord-001835-0s7ok4uw	1488	4	implications	implication	NNS
cord-001835-0s7ok4uw	1488	5	to	to	TO
cord-001835-0s7ok4uw	1488	6	elucidate	elucidate	VB
cord-001835-0s7ok4uw	1488	7	the	the	DT
cord-001835-0s7ok4uw	1488	8	pathogenesis	pathogenesis	NN
cord-001835-0s7ok4uw	1488	9	of	of	IN
cord-001835-0s7ok4uw	1488	10	AML	AML	NNP
cord-001835-0s7ok4uw	1488	11	caused	cause	VBN
cord-001835-0s7ok4uw	1488	12	by	by	IN
cord-001835-0s7ok4uw	1488	13	NPM1	NPM1	NNP
cord-001835-0s7ok4uw	1488	14	mutants	mutant	NNS
cord-001835-0s7ok4uw	1488	15	and	and	CC
cord-001835-0s7ok4uw	1488	16	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1488	17	phenomena	phenomenon	NNS
cord-001835-0s7ok4uw	1488	18	should	should	MD
cord-001835-0s7ok4uw	1488	19	be	be	VB
cord-001835-0s7ok4uw	1488	20	seriously	seriously	RB
cord-001835-0s7ok4uw	1488	21	considered	consider	VBN
cord-001835-0s7ok4uw	1488	22	in	in	IN
cord-001835-0s7ok4uw	1488	23	studies	study	NNS
cord-001835-0s7ok4uw	1488	24	aimed	aim	VBN
cord-001835-0s7ok4uw	1488	25	at	at	IN
cord-001835-0s7ok4uw	1488	26	unveiling	unveil	VBG
cord-001835-0s7ok4uw	1488	27	the	the	DT
cord-001835-0s7ok4uw	1488	28	molecular	molecular	JJ
cord-001835-0s7ok4uw	1488	29	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1488	30	of	of	IN
cord-001835-0s7ok4uw	1488	31	this	this	DT
cord-001835-0s7ok4uw	1488	32	pathology	pathology	NN
cord-001835-0s7ok4uw	1488	33	.	.	.
cord-001835-0s7ok4uw	1488	34	 	 	_SP
cord-001835-0s7ok4uw	1489	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1489	2	report	report	VBP
cord-001835-0s7ok4uw	1489	3	a	a	DT
cord-001835-0s7ok4uw	1489	4	resume	resume	NN
cord-001835-0s7ok4uw	1489	5	of	of	IN
cord-001835-0s7ok4uw	1489	6	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1489	7	study	study	NN
cord-001835-0s7ok4uw	1489	8	regarding	regard	VBG
cord-001835-0s7ok4uw	1489	9	the	the	DT
cord-001835-0s7ok4uw	1489	10	effects	effect	NNS
cord-001835-0s7ok4uw	1489	11	of	of	IN
cord-001835-0s7ok4uw	1489	12	microwaves	microwave	NNS
cord-001835-0s7ok4uw	1489	13	in	in	IN
cord-001835-0s7ok4uw	1489	14	the	the	DT
cord-001835-0s7ok4uw	1489	15	range	range	NN
cord-001835-0s7ok4uw	1489	16	900	900	CD
cord-001835-0s7ok4uw	1489	17	-	-	HYPH
cord-001835-0s7ok4uw	1489	18	1800	1800	CD
cord-001835-0s7ok4uw	1489	19	MHz	MHz	NNS
cord-001835-0s7ok4uw	1489	20	on	on	IN
cord-001835-0s7ok4uw	1489	21	a	a	DT
cord-001835-0s7ok4uw	1489	22	typical	typical	JJ
cord-001835-0s7ok4uw	1489	23	protein	protein	NN
cord-001835-0s7ok4uw	1489	24	,	,	,
cord-001835-0s7ok4uw	1489	25	Myglobin	Myglobin	NNP
cord-001835-0s7ok4uw	1489	26	.	.	.
cord-001835-0s7ok4uw	1490	1	Previous	previous	JJ
cord-001835-0s7ok4uw	1490	2	literature	literature	NN
cord-001835-0s7ok4uw	1490	3	have	have	VBP
cord-001835-0s7ok4uw	1490	4	concerned	concern	VBN
cord-001835-0s7ok4uw	1490	5	the	the	DT
cord-001835-0s7ok4uw	1490	6	effects	effect	NNS
cord-001835-0s7ok4uw	1490	7	on	on	IN
cord-001835-0s7ok4uw	1490	8	living	living	NN
cord-001835-0s7ok4uw	1490	9	and	and	CC
cord-001835-0s7ok4uw	1490	10	in	in	IN
cord-001835-0s7ok4uw	1490	11	vitro	vitro	FW
cord-001835-0s7ok4uw	1490	12	organic	organic	JJ
cord-001835-0s7ok4uw	1490	13	systems	system	NNS
cord-001835-0s7ok4uw	1490	14	induced	induce	VBN
cord-001835-0s7ok4uw	1490	15	by	by	IN
cord-001835-0s7ok4uw	1490	16	high	high	JJ
cord-001835-0s7ok4uw	1490	17	frequencies	frequency	NNS
cord-001835-0s7ok4uw	1490	18	electromagnetic	electromagnetic	VBP
cord-001835-0s7ok4uw	1490	19	fields	field	NNS
cord-001835-0s7ok4uw	1490	20	.	.	.
cord-001835-0s7ok4uw	1491	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1491	2	have	have	VBP
cord-001835-0s7ok4uw	1491	3	focused	focus	VBN
cord-001835-0s7ok4uw	1491	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1491	5	attention	attention	NN
cord-001835-0s7ok4uw	1491	6	on	on	IN
cord-001835-0s7ok4uw	1491	7	a	a	DT
cord-001835-0s7ok4uw	1491	8	typical	typical	JJ
cord-001835-0s7ok4uw	1491	9	protein	protein	NN
cord-001835-0s7ok4uw	1491	10	,	,	,
cord-001835-0s7ok4uw	1491	11	Myoglobin	myoglobin	NN
cord-001835-0s7ok4uw	1491	12	,	,	,
cord-001835-0s7ok4uw	1491	13	because	because	IN
cord-001835-0s7ok4uw	1491	14	proteins	protein	NNS
cord-001835-0s7ok4uw	1491	15	are	be	VBP
cord-001835-0s7ok4uw	1491	16	the	the	DT
cord-001835-0s7ok4uw	1491	17	simplest	simplest	JJ
cord-001835-0s7ok4uw	1491	18	organic	organic	JJ
cord-001835-0s7ok4uw	1491	19	systems	system	NNS
cord-001835-0s7ok4uw	1491	20	that	that	WDT
cord-001835-0s7ok4uw	1491	21	are	be	VBP
cord-001835-0s7ok4uw	1491	22	fundamentals	fundamental	NNS
cord-001835-0s7ok4uw	1491	23	in	in	IN
cord-001835-0s7ok4uw	1491	24	organic	organic	JJ
cord-001835-0s7ok4uw	1491	25	functions	function	NNS
cord-001835-0s7ok4uw	1491	26	of	of	IN
cord-001835-0s7ok4uw	1491	27	livings	living	NNS
cord-001835-0s7ok4uw	1491	28	.	.	.
cord-001835-0s7ok4uw	1492	1	Myoglobin	myoglobin	NN
cord-001835-0s7ok4uw	1492	2	is	be	VBZ
cord-001835-0s7ok4uw	1492	3	a	a	DT
cord-001835-0s7ok4uw	1492	4	protein	protein	NN
cord-001835-0s7ok4uw	1492	5	found	find	VBN
cord-001835-0s7ok4uw	1492	6	mainly	mainly	RB
cord-001835-0s7ok4uw	1492	7	in	in	IN
cord-001835-0s7ok4uw	1492	8	muscle	muscle	NN
cord-001835-0s7ok4uw	1492	9	tissue	tissue	NN
cord-001835-0s7ok4uw	1492	10	of	of	IN
cord-001835-0s7ok4uw	1492	11	vertebrates	vertebrate	NNS
cord-001835-0s7ok4uw	1492	12	,	,	,
cord-001835-0s7ok4uw	1492	13	consisting	consist	VBG
cord-001835-0s7ok4uw	1492	14	of	of	IN
cord-001835-0s7ok4uw	1492	15	a	a	DT
cord-001835-0s7ok4uw	1492	16	single	single	JJ
cord-001835-0s7ok4uw	1492	17	protein	protein	NN
cord-001835-0s7ok4uw	1492	18	chain	chain	NN
cord-001835-0s7ok4uw	1492	19	with	with	IN
cord-001835-0s7ok4uw	1492	20	153	153	CD
cord-001835-0s7ok4uw	1492	21	amino	amino	JJ
cord-001835-0s7ok4uw	1492	22	acids	acid	NNS
cord-001835-0s7ok4uw	1492	23	and	and	CC
cord-001835-0s7ok4uw	1492	24	one	one	CD
cord-001835-0s7ok4uw	1492	25	heme	heme	NN
cord-001835-0s7ok4uw	1492	26	group	group	NN
cord-001835-0s7ok4uw	1492	27	that	that	WDT
cord-001835-0s7ok4uw	1492	28	stores	store	VBZ
cord-001835-0s7ok4uw	1492	29	oxygen	oxygen	NN
cord-001835-0s7ok4uw	1492	30	in	in	IN
cord-001835-0s7ok4uw	1492	31	the	the	DT
cord-001835-0s7ok4uw	1492	32	muscle	muscle	NN
cord-001835-0s7ok4uw	1492	33	cells	cell	NNS
cord-001835-0s7ok4uw	1492	34	.	.	.
cord-001835-0s7ok4uw	1493	1	The	the	DT
cord-001835-0s7ok4uw	1493	2	physiological	physiological	JJ
cord-001835-0s7ok4uw	1493	3	importance	importance	NN
cord-001835-0s7ok4uw	1493	4	of	of	IN
cord-001835-0s7ok4uw	1493	5	Myoglobin	myoglobin	NN
cord-001835-0s7ok4uw	1493	6	is	be	VBZ
cord-001835-0s7ok4uw	1493	7	mainly	mainly	RB
cord-001835-0s7ok4uw	1493	8	related	relate	VBN
cord-001835-0s7ok4uw	1493	9	to	to	IN
cord-001835-0s7ok4uw	1493	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1493	11	ability	ability	NN
cord-001835-0s7ok4uw	1493	12	to	to	TO
cord-001835-0s7ok4uw	1493	13	bind	bind	VB
cord-001835-0s7ok4uw	1493	14	molecular	molecular	JJ
cord-001835-0s7ok4uw	1493	15	oxygen	oxygen	NN
cord-001835-0s7ok4uw	1493	16	.	.	.
cord-001835-0s7ok4uw	1494	1	In	in	IN
cord-001835-0s7ok4uw	1494	2	particular	particular	JJ
cord-001835-0s7ok4uw	1494	3	,	,	,
cord-001835-0s7ok4uw	1494	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	1494	5	focused	focus	VBD
cord-001835-0s7ok4uw	1494	6	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1494	7	attention	attention	NN
cord-001835-0s7ok4uw	1494	8	on	on	IN
cord-001835-0s7ok4uw	1494	9	the	the	DT
cord-001835-0s7ok4uw	1494	10	secondary	secondary	JJ
cord-001835-0s7ok4uw	1494	11	structure	structure	NN
cord-001835-0s7ok4uw	1494	12	of	of	IN
cord-001835-0s7ok4uw	1494	13	this	this	DT
cord-001835-0s7ok4uw	1494	14	protein	protein	NN
cord-001835-0s7ok4uw	1494	15	in	in	IN
cord-001835-0s7ok4uw	1494	16	order	order	NN
cord-001835-0s7ok4uw	1494	17	to	to	TO
cord-001835-0s7ok4uw	1494	18	highlight	highlight	VB
cord-001835-0s7ok4uw	1494	19	whether	whether	IN
cord-001835-0s7ok4uw	1494	20	exposure	exposure	NN
cord-001835-0s7ok4uw	1494	21	to	to	IN
cord-001835-0s7ok4uw	1494	22	microwaves	microwave	NNS
cord-001835-0s7ok4uw	1494	23	unfold	unfold	VBP
cord-001835-0s7ok4uw	1494	24	the	the	DT
cord-001835-0s7ok4uw	1494	25	protein	protein	NN
cord-001835-0s7ok4uw	1494	26	producing	produce	VBG
cord-001835-0s7ok4uw	1494	27	transitions	transition	NNS
cord-001835-0s7ok4uw	1494	28	from	from	IN
cord-001835-0s7ok4uw	1494	29	a	a	DT
cord-001835-0s7ok4uw	1494	30	-	-	HYPH
cord-001835-0s7ok4uw	1494	31	helix	helix	NN
cord-001835-0s7ok4uw	1494	32	component	component	NN
cord-001835-0s7ok4uw	1494	33	to	to	IN
cord-001835-0s7ok4uw	1494	34	b	b	NN
cord-001835-0s7ok4uw	1494	35	-	-	HYPH
cord-001835-0s7ok4uw	1494	36	sheet	sheet	NN
cord-001835-0s7ok4uw	1494	37	features	feature	NNS
cord-001835-0s7ok4uw	1494	38	.	.	.
cord-001835-0s7ok4uw	1495	1	To	to	IN
cord-001835-0s7ok4uw	1495	2	this	this	DT
cord-001835-0s7ok4uw	1495	3	aim	aim	VB
cord-001835-0s7ok4uw	1495	4	Fourier	Fourier	NNP
cord-001835-0s7ok4uw	1495	5	Transform	Transform	NNP
cord-001835-0s7ok4uw	1495	6	Infrared	Infrared	NNP
cord-001835-0s7ok4uw	1495	7	(	(	-LRB-
cord-001835-0s7ok4uw	1495	8	FTIR	FTIR	NNP
cord-001835-0s7ok4uw	1495	9	)	)	-RRB-
cord-001835-0s7ok4uw	1495	10	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1495	11	have	have	VBP
cord-001835-0s7ok4uw	1495	12	been	be	VBN
cord-001835-0s7ok4uw	1495	13	used	use	VBN
cord-001835-0s7ok4uw	1495	14	.	.	.
cord-001835-0s7ok4uw	1496	1	The	the	DT
cord-001835-0s7ok4uw	1496	2	importance	importance	NN
cord-001835-0s7ok4uw	1496	3	of	of	IN
cord-001835-0s7ok4uw	1496	4	this	this	DT
cord-001835-0s7ok4uw	1496	5	study	study	NN
cord-001835-0s7ok4uw	1496	6	is	be	VBZ
cord-001835-0s7ok4uw	1496	7	related	relate	VBN
cord-001835-0s7ok4uw	1496	8	to	to	IN
cord-001835-0s7ok4uw	1496	9	previous	previous	JJ
cord-001835-0s7ok4uw	1496	10	literature	literature	NN
cord-001835-0s7ok4uw	1496	11	which	which	WDT
cord-001835-0s7ok4uw	1496	12	indicated	indicate	VBD
cord-001835-0s7ok4uw	1496	13	that	that	IN
cord-001835-0s7ok4uw	1496	14	transition	transition	NN
cord-001835-0s7ok4uw	1496	15	from	from	IN
cord-001835-0s7ok4uw	1496	16	a	a	DT
cord-001835-0s7ok4uw	1496	17	-	-	HYPH
cord-001835-0s7ok4uw	1496	18	helix	helix	NN
cord-001835-0s7ok4uw	1496	19	to	to	IN
cord-001835-0s7ok4uw	1496	20	b	b	NN
cord-001835-0s7ok4uw	1496	21	-	-	HYPH
cord-001835-0s7ok4uw	1496	22	sheet	sheet	NN
cord-001835-0s7ok4uw	1496	23	structure	structure	NN
cord-001835-0s7ok4uw	1496	24	in	in	IN
cord-001835-0s7ok4uw	1496	25	a	a	DT
cord-001835-0s7ok4uw	1496	26	protein	protein	NN
cord-001835-0s7ok4uw	1496	27	can	can	MD
cord-001835-0s7ok4uw	1496	28	be	be	VB
cord-001835-0s7ok4uw	1496	29	responsible	responsible	JJ
cord-001835-0s7ok4uw	1496	30	for	for	IN
cord-001835-0s7ok4uw	1496	31	aggregation	aggregation	NN
cord-001835-0s7ok4uw	1496	32	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1496	33	that	that	WDT
cord-001835-0s7ok4uw	1496	34	can	can	MD
cord-001835-0s7ok4uw	1496	35	lead	lead	VB
cord-001835-0s7ok4uw	1496	36	to	to	IN
cord-001835-0s7ok4uw	1496	37	neurotoxicity	neurotoxicity	NN
cord-001835-0s7ok4uw	1496	38	and	and	CC
cord-001835-0s7ok4uw	1496	39	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	1496	40	disorders	disorder	NNS
cord-001835-0s7ok4uw	1496	41	that	that	WDT
cord-001835-0s7ok4uw	1496	42	can	can	MD
cord-001835-0s7ok4uw	1496	43	be	be	VB
cord-001835-0s7ok4uw	1496	44	considered	consider	VBN
cord-001835-0s7ok4uw	1496	45	as	as	IN
cord-001835-0s7ok4uw	1496	46	the	the	DT
cord-001835-0s7ok4uw	1496	47	first	first	JJ
cord-001835-0s7ok4uw	1496	48	step	step	NN
cord-001835-0s7ok4uw	1496	49	to	to	IN
cord-001835-0s7ok4uw	1496	50	some	some	DT
cord-001835-0s7ok4uw	1496	51	pathologies	pathology	NNS
cord-001835-0s7ok4uw	1496	52	[	[	-LRB-
cord-001835-0s7ok4uw	1496	53	1	1	CD
cord-001835-0s7ok4uw	1496	54	]	]	-RRB-
cord-001835-0s7ok4uw	1496	55	[	[	-LRB-
cord-001835-0s7ok4uw	1496	56	2	2	CD
cord-001835-0s7ok4uw	1496	57	]	]	-RRB-
cord-001835-0s7ok4uw	1496	58	[	[	-LRB-
cord-001835-0s7ok4uw	1496	59	3	3	CD
cord-001835-0s7ok4uw	1496	60	]	]	-RRB-
cord-001835-0s7ok4uw	1496	61	.	.	.
cord-001835-0s7ok4uw	1497	1	The	the	DT
cord-001835-0s7ok4uw	1497	2	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	1497	3	consist	consist	VBP
cord-001835-0s7ok4uw	1497	4	of	of	IN
cord-001835-0s7ok4uw	1497	5	fibers	fiber	NNS
cord-001835-0s7ok4uw	1497	6	containing	contain	VBG
cord-001835-0s7ok4uw	1497	7	unfolded	unfold	VBN
cord-001835-0s7ok4uw	1497	8	proteins	protein	NNS
cord-001835-0s7ok4uw	1497	9	with	with	IN
cord-001835-0s7ok4uw	1497	10	a	a	DT
cord-001835-0s7ok4uw	1497	11	prevalent	prevalent	JJ
cord-001835-0s7ok4uw	1497	12	b	b	NN
cord-001835-0s7ok4uw	1497	13	-	-	HYPH
cord-001835-0s7ok4uw	1497	14	sheet	sheet	NN
cord-001835-0s7ok4uw	1497	15	structure	structure	NN
cord-001835-0s7ok4uw	1497	16	termed	term	VBN
cord-001835-0s7ok4uw	1497	17	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1497	18	[	[	-LRB-
cord-001835-0s7ok4uw	1497	19	4	4	CD
cord-001835-0s7ok4uw	1497	20	]	]	-RRB-
cord-001835-0s7ok4uw	1497	21	.	.	.
cord-001835-0s7ok4uw	1498	1	In	in	IN
cord-001835-0s7ok4uw	1498	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1498	3	studies	study	NNS
cord-001835-0s7ok4uw	1498	4	Myoglobin	myoglobin	NN
cord-001835-0s7ok4uw	1498	5	in	in	IN
cord-001835-0s7ok4uw	1498	6	deuterium	deuterium	NN
cord-001835-0s7ok4uw	1498	7	oxide	oxide	NN
cord-001835-0s7ok4uw	1499	1	(	(	-LRB-
cord-001835-0s7ok4uw	1499	2	D2O	d2o	NN
cord-001835-0s7ok4uw	1499	3	)	)	-RRB-
cord-001835-0s7ok4uw	1499	4	solution	solution	NN
cord-001835-0s7ok4uw	1499	5	was	be	VBD
cord-001835-0s7ok4uw	1499	6	exposed	expose	VBN
cord-001835-0s7ok4uw	1499	7	for	for	IN
cord-001835-0s7ok4uw	1499	8	3	3	CD
cord-001835-0s7ok4uw	1499	9	h	h	NN
cord-001835-0s7ok4uw	1499	10	to	to	IN
cord-001835-0s7ok4uw	1499	11	mobile	mobile	JJ
cord-001835-0s7ok4uw	1499	12	phone	phone	NN
cord-001835-0s7ok4uw	1499	13	microwaves	microwave	NNS
cord-001835-0s7ok4uw	1499	14	at	at	IN
cord-001835-0s7ok4uw	1499	15	900	900	CD
cord-001835-0s7ok4uw	1499	16	and	and	CC
cord-001835-0s7ok4uw	1499	17	1800	1800	CD
cord-001835-0s7ok4uw	1499	18	MHz	MHz	NNS
cord-001835-0s7ok4uw	1499	19	at	at	IN
cord-001835-0s7ok4uw	1499	20	a	a	DT
cord-001835-0s7ok4uw	1499	21	power	power	NN
cord-001835-0s7ok4uw	1499	22	density	density	NN
cord-001835-0s7ok4uw	1499	23	of	of	IN
cord-001835-0s7ok4uw	1499	24	1	1	CD
cord-001835-0s7ok4uw	1499	25	W	W	NNP
cord-001835-0s7ok4uw	1499	26	/	/	SYM
cord-001835-0s7ok4uw	1499	27	m2	m2	NNP
cord-001835-0s7ok4uw	1499	28	.	.	.
cord-001835-0s7ok4uw	1500	1	FTIR	FTIR	NNP
cord-001835-0s7ok4uw	1500	2	spectra	spectrum	NNS
cord-001835-0s7ok4uw	1500	3	were	be	VBD
cord-001835-0s7ok4uw	1500	4	recorded	record	VBN
cord-001835-0s7ok4uw	1500	5	by	by	IN
cord-001835-0s7ok4uw	1500	6	a	a	DT
cord-001835-0s7ok4uw	1500	7	spectrometer	spectrometer	NN
cord-001835-0s7ok4uw	1500	8	Vertex	Vertex	NNP
cord-001835-0s7ok4uw	1500	9	80v	80v	NNPS
cord-001835-0s7ok4uw	1500	10	from	from	IN
cord-001835-0s7ok4uw	1500	11	Bruker	Bruker	NNP
cord-001835-0s7ok4uw	1500	12	Optics	Optics	NNP
cord-001835-0s7ok4uw	1500	13	,	,	,
cord-001835-0s7ok4uw	1500	14	following	follow	VBG
cord-001835-0s7ok4uw	1500	15	the	the	DT
cord-001835-0s7ok4uw	1500	16	protocol	protocol	NN
cord-001835-0s7ok4uw	1500	17	accurately	accurately	RB
cord-001835-0s7ok4uw	1500	18	described	describe	VBN
cord-001835-0s7ok4uw	1500	19	in	in	IN
cord-001835-0s7ok4uw	1500	20	[	[	-LRB-
cord-001835-0s7ok4uw	1500	21	5	5	CD
cord-001835-0s7ok4uw	1500	22	]	]	-RRB-
cord-001835-0s7ok4uw	1500	23	[	[	-LRB-
cord-001835-0s7ok4uw	1500	24	6	6	CD
cord-001835-0s7ok4uw	1500	25	]	]	-RRB-
cord-001835-0s7ok4uw	1500	26	[	[	-LRB-
cord-001835-0s7ok4uw	1500	27	7	7	CD
cord-001835-0s7ok4uw	1500	28	]	]	-RRB-
cord-001835-0s7ok4uw	1500	29	.	.	.
cord-001835-0s7ok4uw	1501	1	FTIR	FTIR	NNP
cord-001835-0s7ok4uw	1501	2	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1501	3	analysis	analysis	NN
cord-001835-0s7ok4uw	1501	4	evidenced	evidence	VBD
cord-001835-0s7ok4uw	1501	5	an	an	DT
cord-001835-0s7ok4uw	1501	6	increase	increase	NN
cord-001835-0s7ok4uw	1501	7	in	in	IN
cord-001835-0s7ok4uw	1501	8	intensity	intensity	NN
cord-001835-0s7ok4uw	1501	9	of	of	IN
cord-001835-0s7ok4uw	1501	10	b	b	NN
cord-001835-0s7ok4uw	1501	11	-	-	HYPH
cord-001835-0s7ok4uw	1501	12	sheet	sheet	NN
cord-001835-0s7ok4uw	1501	13	structures	structure	NNS
cord-001835-0s7ok4uw	1501	14	and	and	CC
cord-001835-0s7ok4uw	1501	15	a	a	DT
cord-001835-0s7ok4uw	1501	16	significant	significant	JJ
cord-001835-0s7ok4uw	1501	17	shift	shift	NN
cord-001835-0s7ok4uw	1501	18	to	to	TO
cord-001835-0s7ok4uw	1501	19	lower	lower	VB
cord-001835-0s7ok4uw	1501	20	frequencies	frequency	NNS
cord-001835-0s7ok4uw	1501	21	of	of	IN
cord-001835-0s7ok4uw	1501	22	about	about	RB
cord-001835-0s7ok4uw	1501	23	2.5	2.5	CD
cord-001835-0s7ok4uw	1501	24	cm-1	cm-1	XX
cord-001835-0s7ok4uw	1501	25	of	of	IN
cord-001835-0s7ok4uw	1501	26	the	the	DT
cord-001835-0s7ok4uw	1501	27	amide	amide	NN
cord-001835-0s7ok4uw	1501	28	I	-PRON-	PRP
cord-001835-0s7ok4uw	1501	29	vibration	vibration	NN
cord-001835-0s7ok4uw	1501	30	after	after	IN
cord-001835-0s7ok4uw	1501	31	exposure	exposure	NN
cord-001835-0s7ok4uw	1501	32	[	[	-LRB-
cord-001835-0s7ok4uw	1501	33	8	8	CD
cord-001835-0s7ok4uw	1501	34	,	,	,
cord-001835-0s7ok4uw	1501	35	9	9	CD
cord-001835-0s7ok4uw	1501	36	]	]	-RRB-
cord-001835-0s7ok4uw	1501	37	.	.	.
cord-001835-0s7ok4uw	1502	1	These	these	DT
cord-001835-0s7ok4uw	1502	2	results	result	NNS
cord-001835-0s7ok4uw	1502	3	led	lead	VBD
cord-001835-0s7ok4uw	1502	4	to	to	TO
cord-001835-0s7ok4uw	1502	5	conclude	conclude	VB
cord-001835-0s7ok4uw	1502	6	that	that	IN
cord-001835-0s7ok4uw	1502	7	mobile	mobile	JJ
cord-001835-0s7ok4uw	1502	8	phone	phone	NN
cord-001835-0s7ok4uw	1502	9	microwaves	microwave	NNS
cord-001835-0s7ok4uw	1502	10	induce	induce	VBP
cord-001835-0s7ok4uw	1502	11	proteins	protein	NNS
cord-001835-0s7ok4uw	1502	12	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1502	13	and	and	CC
cord-001835-0s7ok4uw	1502	14	formation	formation	NN
cord-001835-0s7ok4uw	1502	15	of	of	IN
cord-001835-0s7ok4uw	1502	16	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	1502	17	[	[	-LRB-
cord-001835-0s7ok4uw	1502	18	10	10	CD
cord-001835-0s7ok4uw	1502	19	,	,	,
cord-001835-0s7ok4uw	1502	20	11	11	CD
cord-001835-0s7ok4uw	1502	21	]	]	-RRB-
cord-001835-0s7ok4uw	1502	22	.	.	.
cord-001835-0s7ok4uw	1502	23	 	 	_SP
cord-001835-0s7ok4uw	1503	1	Membrane	membrane	NN
cord-001835-0s7ok4uw	1503	2	proteins	protein	NNS
cord-001835-0s7ok4uw	1503	3	play	play	VBP
cord-001835-0s7ok4uw	1503	4	a	a	DT
cord-001835-0s7ok4uw	1503	5	vital	vital	JJ
cord-001835-0s7ok4uw	1503	6	role	role	NN
cord-001835-0s7ok4uw	1503	7	in	in	IN
cord-001835-0s7ok4uw	1503	8	many	many	JJ
cord-001835-0s7ok4uw	1503	9	biological	biological	JJ
cord-001835-0s7ok4uw	1503	10	processes	process	NNS
cord-001835-0s7ok4uw	1503	11	,	,	,
cord-001835-0s7ok4uw	1503	12	and	and	CC
cord-001835-0s7ok4uw	1503	13	yet	yet	RB
cord-001835-0s7ok4uw	1503	14	remain	remain	VBP
cord-001835-0s7ok4uw	1503	15	poorly	poorly	RB
cord-001835-0s7ok4uw	1503	16	understood	understand	VBN
cord-001835-0s7ok4uw	1503	17	as	as	IN
cord-001835-0s7ok4uw	1503	18	they	-PRON-	PRP
cord-001835-0s7ok4uw	1503	19	are	be	VBP
cord-001835-0s7ok4uw	1503	20	frequently	frequently	RB
cord-001835-0s7ok4uw	1503	21	unstable	unstable	JJ
cord-001835-0s7ok4uw	1503	22	in	in	IN
cord-001835-0s7ok4uw	1503	23	vitro	vitro	FW
cord-001835-0s7ok4uw	1503	24	.	.	.
cord-001835-0s7ok4uw	1504	1	The	the	DT
cord-001835-0s7ok4uw	1504	2	goal	goal	NN
cord-001835-0s7ok4uw	1504	3	of	of	IN
cord-001835-0s7ok4uw	1504	4	this	this	DT
cord-001835-0s7ok4uw	1504	5	project	project	NN
cord-001835-0s7ok4uw	1504	6	is	be	VBZ
cord-001835-0s7ok4uw	1504	7	to	to	TO
cord-001835-0s7ok4uw	1504	8	investigate	investigate	VB
cord-001835-0s7ok4uw	1504	9	the	the	DT
cord-001835-0s7ok4uw	1504	10	insertion	insertion	NN
cord-001835-0s7ok4uw	1504	11	and	and	CC
cord-001835-0s7ok4uw	1504	12	folding	folding	NN
cord-001835-0s7ok4uw	1504	13	of	of	IN
cord-001835-0s7ok4uw	1504	14	membrane	membrane	NN
cord-001835-0s7ok4uw	1504	15	proteins	protein	NNS
cord-001835-0s7ok4uw	1504	16	into	into	IN
cord-001835-0s7ok4uw	1504	17	lipid	lipid	NN
cord-001835-0s7ok4uw	1504	18	bilayers	bilayer	NNS
cord-001835-0s7ok4uw	1504	19	,	,	,
cord-001835-0s7ok4uw	1504	20	using	use	VBG
cord-001835-0s7ok4uw	1504	21	a	a	DT
cord-001835-0s7ok4uw	1504	22	cell	cell	NN
cord-001835-0s7ok4uw	1504	23	free	free	JJ
cord-001835-0s7ok4uw	1504	24	expression	expression	NN
cord-001835-0s7ok4uw	1504	25	system	system	NN
cord-001835-0s7ok4uw	1504	26	.	.	.
cord-001835-0s7ok4uw	1505	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1505	2	have	have	VBP
cord-001835-0s7ok4uw	1505	3	used	use	VBN
cord-001835-0s7ok4uw	1505	4	both	both	DT
cord-001835-0s7ok4uw	1505	5	E.colibased	e.colibased	JJ
cord-001835-0s7ok4uw	1505	6	cell	cell	NN
cord-001835-0s7ok4uw	1505	7	extracts	extract	NNS
cord-001835-0s7ok4uw	1505	8	(	(	-LRB-
cord-001835-0s7ok4uw	1505	9	S30	S30	NNP
cord-001835-0s7ok4uw	1505	10	)	)	-RRB-
cord-001835-0s7ok4uw	1505	11	,	,	,
cord-001835-0s7ok4uw	1505	12	and	and	CC
cord-001835-0s7ok4uw	1505	13	commercial	commercial	JJ
cord-001835-0s7ok4uw	1505	14	translation	translation	NN
cord-001835-0s7ok4uw	1505	15	systems	system	NNS
cord-001835-0s7ok4uw	1505	16	(	(	-LRB-
cord-001835-0s7ok4uw	1505	17	PURExpress	PURExpress	NNP
cord-001835-0s7ok4uw	1505	18	)	)	-RRB-
cord-001835-0s7ok4uw	1505	19	in	in	IN
cord-001835-0s7ok4uw	1505	20	combination	combination	NN
cord-001835-0s7ok4uw	1505	21	with	with	IN
cord-001835-0s7ok4uw	1505	22	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	1505	23	liposomes	liposome	NNS
cord-001835-0s7ok4uw	1505	24	of	of	IN
cord-001835-0s7ok4uw	1505	25	defined	define	VBN
cord-001835-0s7ok4uw	1505	26	lipid	lipid	NN
cord-001835-0s7ok4uw	1505	27	composition	composition	NN
cord-001835-0s7ok4uw	1505	28	.	.	.
cord-001835-0s7ok4uw	1506	1	These	these	DT
cord-001835-0s7ok4uw	1506	2	studies	study	NNS
cord-001835-0s7ok4uw	1506	3	will	will	MD
cord-001835-0s7ok4uw	1506	4	aid	aid	VB
cord-001835-0s7ok4uw	1506	5	understanding	understanding	NN
cord-001835-0s7ok4uw	1506	6	of	of	IN
cord-001835-0s7ok4uw	1506	7	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	1506	8	folding	folding	NN
cord-001835-0s7ok4uw	1506	9	,	,	,
cord-001835-0s7ok4uw	1506	10	folding	folding	NN
cord-001835-0s7ok4uw	1506	11	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	1506	12	,	,	,
cord-001835-0s7ok4uw	1506	13	and	and	CC
cord-001835-0s7ok4uw	1506	14	the	the	DT
cord-001835-0s7ok4uw	1506	15	effects	effect	NNS
cord-001835-0s7ok4uw	1506	16	of	of	IN
cord-001835-0s7ok4uw	1506	17	the	the	DT
cord-001835-0s7ok4uw	1506	18	lipid	lipid	NN
cord-001835-0s7ok4uw	1506	19	bilayer	bilayer	NN
cord-001835-0s7ok4uw	1506	20	on	on	IN
cord-001835-0s7ok4uw	1506	21	folding	folding	NN
cord-001835-0s7ok4uw	1506	22	and	and	CC
cord-001835-0s7ok4uw	1506	23	insertion	insertion	NN
cord-001835-0s7ok4uw	1506	24	.	.	.
cord-001835-0s7ok4uw	1507	1	Model	model	NN
cord-001835-0s7ok4uw	1507	2	E.coli	E.coli	NNS
cord-001835-0s7ok4uw	1507	3	proteins	protein	NNS
cord-001835-0s7ok4uw	1507	4	have	have	VBP
cord-001835-0s7ok4uw	1507	5	been	be	VBN
cord-001835-0s7ok4uw	1507	6	investigated	investigate	VBN
cord-001835-0s7ok4uw	1507	7	,	,	,
cord-001835-0s7ok4uw	1507	8	as	as	IN
cord-001835-0s7ok4uw	1507	9	they	-PRON-	PRP
cord-001835-0s7ok4uw	1507	10	can	can	MD
cord-001835-0s7ok4uw	1507	11	offer	offer	VB
cord-001835-0s7ok4uw	1507	12	important	important	JJ
cord-001835-0s7ok4uw	1507	13	insights	insight	NNS
cord-001835-0s7ok4uw	1507	14	into	into	IN
cord-001835-0s7ok4uw	1507	15	other	other	JJ
cord-001835-0s7ok4uw	1507	16	proteins	protein	NNS
cord-001835-0s7ok4uw	1507	17	,	,	,
cord-001835-0s7ok4uw	1507	18	and	and	CC
cord-001835-0s7ok4uw	1507	19	thus	thus	RB
cord-001835-0s7ok4uw	1507	20	facilitate	facilitate	VB
cord-001835-0s7ok4uw	1507	21	the	the	DT
cord-001835-0s7ok4uw	1507	22	further	further	JJ
cord-001835-0s7ok4uw	1507	23	study	study	NN
cord-001835-0s7ok4uw	1507	24	of	of	IN
cord-001835-0s7ok4uw	1507	25	more	more	RBR
cord-001835-0s7ok4uw	1507	26	biologically	biologically	RB
cord-001835-0s7ok4uw	1507	27	relevant	relevant	JJ
cord-001835-0s7ok4uw	1507	28	proteins	protein	NNS
cord-001835-0s7ok4uw	1507	29	.	.	.
cord-001835-0s7ok4uw	1508	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1508	2	has	have	VBZ
cord-001835-0s7ok4uw	1508	3	been	be	VBN
cord-001835-0s7ok4uw	1508	4	found	find	VBN
cord-001835-0s7ok4uw	1508	5	that	that	IN
cord-001835-0s7ok4uw	1508	6	the	the	DT
cord-001835-0s7ok4uw	1508	7	rhomboid	rhomboid	JJ
cord-001835-0s7ok4uw	1508	8	protease	protease	NN
cord-001835-0s7ok4uw	1508	9	GlpG	GlpG	NNP
cord-001835-0s7ok4uw	1508	10	spontaneously	spontaneously	RB
cord-001835-0s7ok4uw	1508	11	inserts	insert	VBZ
cord-001835-0s7ok4uw	1508	12	into	into	IN
cord-001835-0s7ok4uw	1508	13	liposomes	liposome	NNS
cord-001835-0s7ok4uw	1508	14	without	without	IN
cord-001835-0s7ok4uw	1508	15	the	the	DT
cord-001835-0s7ok4uw	1508	16	aid	aid	NN
cord-001835-0s7ok4uw	1508	17	of	of	IN
cord-001835-0s7ok4uw	1508	18	an	an	DT
cord-001835-0s7ok4uw	1508	19	insertase	insertase	NN
cord-001835-0s7ok4uw	1508	20	such	such	JJ
cord-001835-0s7ok4uw	1508	21	as	as	IN
cord-001835-0s7ok4uw	1508	22	SecYEG	SecYEG	NNP
cord-001835-0s7ok4uw	1508	23	.	.	.
cord-001835-0s7ok4uw	1509	1	This	this	DT
cord-001835-0s7ok4uw	1509	2	spontaneously	spontaneously	RB
cord-001835-0s7ok4uw	1509	3	inserted	insert	VBD
cord-001835-0s7ok4uw	1509	4	GlpG	GlpG	NNP
cord-001835-0s7ok4uw	1509	5	is	be	VBZ
cord-001835-0s7ok4uw	1509	6	functional	functional	JJ
cord-001835-0s7ok4uw	1509	7	,	,	,
cord-001835-0s7ok4uw	1509	8	and	and	CC
cord-001835-0s7ok4uw	1509	9	is	be	VBZ
cord-001835-0s7ok4uw	1509	10	able	able	JJ
cord-001835-0s7ok4uw	1509	11	to	to	TO
cord-001835-0s7ok4uw	1509	12	cleave	cleave	VB
cord-001835-0s7ok4uw	1509	13	BODIPY	BODIPY	NNP
cord-001835-0s7ok4uw	1509	14	-	-	HYPH
cord-001835-0s7ok4uw	1509	15	labeled	label	VBN
cord-001835-0s7ok4uw	1509	16	casein	casein	NN
cord-001835-0s7ok4uw	1509	17	,	,	,
cord-001835-0s7ok4uw	1509	18	yielding	yield	VBG
cord-001835-0s7ok4uw	1509	19	a	a	DT
cord-001835-0s7ok4uw	1509	20	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	1509	21	product	product	NN
cord-001835-0s7ok4uw	1509	22	.	.	.
cord-001835-0s7ok4uw	1510	1	The	the	DT
cord-001835-0s7ok4uw	1510	2	Major	Major	NNP
cord-001835-0s7ok4uw	1510	3	Facilitator	Facilitator	NNP
cord-001835-0s7ok4uw	1510	4	Superfamily	Superfamily	NNP
cord-001835-0s7ok4uw	1510	5	(	(	-LRB-
cord-001835-0s7ok4uw	1510	6	MFS	MFS	NNP
cord-001835-0s7ok4uw	1510	7	)	)	-RRB-
cord-001835-0s7ok4uw	1510	8	transport	transport	NN
cord-001835-0s7ok4uw	1510	9	proteins	protein	NNS
cord-001835-0s7ok4uw	1510	10	LacY	LacY	NNP
cord-001835-0s7ok4uw	1510	11	,	,	,
cord-001835-0s7ok4uw	1510	12	GalP	GalP	NNP
cord-001835-0s7ok4uw	1510	13	and	and	CC
cord-001835-0s7ok4uw	1510	14	GlpT	GlpT	NNP
cord-001835-0s7ok4uw	1510	15	have	have	VBP
cord-001835-0s7ok4uw	1510	16	also	also	RB
cord-001835-0s7ok4uw	1510	17	been	be	VBN
cord-001835-0s7ok4uw	1510	18	found	find	VBN
cord-001835-0s7ok4uw	1510	19	to	to	TO
cord-001835-0s7ok4uw	1510	20	insert	insert	VB
cord-001835-0s7ok4uw	1510	21	spontaneously	spontaneously	RB
cord-001835-0s7ok4uw	1510	22	into	into	IN
cord-001835-0s7ok4uw	1510	23	liposomes	liposome	NNS
cord-001835-0s7ok4uw	1510	24	.	.	.
cord-001835-0s7ok4uw	1511	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1511	2	has	have	VBZ
cord-001835-0s7ok4uw	1511	3	been	be	VBN
cord-001835-0s7ok4uw	1511	4	shown	show	VBN
cord-001835-0s7ok4uw	1511	5	that	that	IN
cord-001835-0s7ok4uw	1511	6	the	the	DT
cord-001835-0s7ok4uw	1511	7	lipid	lipid	NN
cord-001835-0s7ok4uw	1511	8	composition	composition	NN
cord-001835-0s7ok4uw	1511	9	of	of	IN
cord-001835-0s7ok4uw	1511	10	the	the	DT
cord-001835-0s7ok4uw	1511	11	liposomes	liposome	NNS
cord-001835-0s7ok4uw	1511	12	has	have	VBZ
cord-001835-0s7ok4uw	1511	13	an	an	DT
cord-001835-0s7ok4uw	1511	14	effect	effect	NN
cord-001835-0s7ok4uw	1511	15	on	on	IN
cord-001835-0s7ok4uw	1511	16	the	the	DT
cord-001835-0s7ok4uw	1511	17	amount	amount	NN
cord-001835-0s7ok4uw	1511	18	of	of	IN
cord-001835-0s7ok4uw	1511	19	protein	protein	NN
cord-001835-0s7ok4uw	1511	20	inserted	insert	VBN
cord-001835-0s7ok4uw	1511	21	into	into	IN
cord-001835-0s7ok4uw	1511	22	the	the	DT
cord-001835-0s7ok4uw	1511	23	bilayer	bilayer	NN
cord-001835-0s7ok4uw	1511	24	,	,	,
cord-001835-0s7ok4uw	1511	25	with	with	IN
cord-001835-0s7ok4uw	1511	26	all	all	DT
cord-001835-0s7ok4uw	1511	27	proteins	protein	NNS
cord-001835-0s7ok4uw	1511	28	tested	test	VBN
cord-001835-0s7ok4uw	1511	29	to	to	IN
cord-001835-0s7ok4uw	1511	30	date	date	NN
cord-001835-0s7ok4uw	1511	31	preferring	preferring	NN
cord-001835-0s7ok4uw	1511	32	liposomes	liposome	NNS
cord-001835-0s7ok4uw	1511	33	containing	contain	VBG
cord-001835-0s7ok4uw	1511	34	at	at	RB
cord-001835-0s7ok4uw	1511	35	least	least	JJS
cord-001835-0s7ok4uw	1511	36	50	50	CD
cord-001835-0s7ok4uw	1511	37	mol%	mol%	JJ
cord-001835-0s7ok4uw	1511	38	DOPG	DOPG	NNP
cord-001835-0s7ok4uw	1511	39	.	.	.
cord-001835-0s7ok4uw	1512	1	Ongoing	ongoing	JJ
cord-001835-0s7ok4uw	1512	2	and	and	CC
cord-001835-0s7ok4uw	1512	3	future	future	JJ
cord-001835-0s7ok4uw	1512	4	work	work	NN
cord-001835-0s7ok4uw	1512	5	will	will	MD
cord-001835-0s7ok4uw	1512	6	involve	involve	VB
cord-001835-0s7ok4uw	1512	7	the	the	DT
cord-001835-0s7ok4uw	1512	8	use	use	NN
cord-001835-0s7ok4uw	1512	9	of	of	IN
cord-001835-0s7ok4uw	1512	10	rare	rare	JJ
cord-001835-0s7ok4uw	1512	11	codons	codon	NNS
cord-001835-0s7ok4uw	1512	12	to	to	TO
cord-001835-0s7ok4uw	1512	13	alter	alter	VB
cord-001835-0s7ok4uw	1512	14	the	the	DT
cord-001835-0s7ok4uw	1512	15	rate	rate	NN
cord-001835-0s7ok4uw	1512	16	of	of	IN
cord-001835-0s7ok4uw	1512	17	translation	translation	NN
cord-001835-0s7ok4uw	1512	18	,	,	,
cord-001835-0s7ok4uw	1512	19	to	to	TO
cord-001835-0s7ok4uw	1512	20	investigate	investigate	VB
cord-001835-0s7ok4uw	1512	21	the	the	DT
cord-001835-0s7ok4uw	1512	22	effect	effect	NN
cord-001835-0s7ok4uw	1512	23	this	this	DT
cord-001835-0s7ok4uw	1512	24	has	have	VBZ
cord-001835-0s7ok4uw	1512	25	on	on	IN
cord-001835-0s7ok4uw	1512	26	the	the	DT
cord-001835-0s7ok4uw	1512	27	final	final	JJ
cord-001835-0s7ok4uw	1512	28	folded	folded	JJ
cord-001835-0s7ok4uw	1512	29	structure	structure	NN
cord-001835-0s7ok4uw	1512	30	of	of	IN
cord-001835-0s7ok4uw	1512	31	the	the	DT
cord-001835-0s7ok4uw	1512	32	protein	protein	NN
cord-001835-0s7ok4uw	1512	33	.	.	.
cord-001835-0s7ok4uw	1513	1	Preliminary	preliminary	JJ
cord-001835-0s7ok4uw	1513	2	work	work	NN
cord-001835-0s7ok4uw	1513	3	is	be	VBZ
cord-001835-0s7ok4uw	1513	4	also	also	RB
cord-001835-0s7ok4uw	1513	5	currently	currently	RB
cord-001835-0s7ok4uw	1513	6	being	be	VBG
cord-001835-0s7ok4uw	1513	7	done	do	VBN
cord-001835-0s7ok4uw	1513	8	into	into	IN
cord-001835-0s7ok4uw	1513	9	whether	whether	IN
cord-001835-0s7ok4uw	1513	10	the	the	DT
cord-001835-0s7ok4uw	1513	11	two	two	CD
cord-001835-0s7ok4uw	1513	12	domains	domain	NNS
cord-001835-0s7ok4uw	1513	13	of	of	IN
cord-001835-0s7ok4uw	1513	14	the	the	DT
cord-001835-0s7ok4uw	1513	15	MFS	MFS	NNP
cord-001835-0s7ok4uw	1513	16	family	family	NN
cord-001835-0s7ok4uw	1513	17	transporters	transporter	NNS
cord-001835-0s7ok4uw	1513	18	fold	fold	VBP
cord-001835-0s7ok4uw	1513	19	cooperatively	cooperatively	RB
cord-001835-0s7ok4uw	1513	20	or	or	CC
cord-001835-0s7ok4uw	1513	21	independently	independently	RB
cord-001835-0s7ok4uw	1513	22	,	,	,
cord-001835-0s7ok4uw	1513	23	thus	thus	RB
cord-001835-0s7ok4uw	1513	24	aiding	aid	VBG
cord-001835-0s7ok4uw	1513	25	understanding	understanding	NN
cord-001835-0s7ok4uw	1513	26	into	into	IN
cord-001835-0s7ok4uw	1513	27	the	the	DT
cord-001835-0s7ok4uw	1513	28	folding	folding	NN
cord-001835-0s7ok4uw	1513	29	and	and	CC
cord-001835-0s7ok4uw	1513	30	stability	stability	NN
cord-001835-0s7ok4uw	1513	31	of	of	IN
cord-001835-0s7ok4uw	1513	32	membrane	membrane	NN
cord-001835-0s7ok4uw	1513	33	transport	transport	NN
cord-001835-0s7ok4uw	1513	34	proteins	protein	NNS
cord-001835-0s7ok4uw	1513	35	.	.	.
cord-001835-0s7ok4uw	1514	1	Frederic	Frederic	NNP
cord-001835-0s7ok4uw	1514	2	Greco	Greco	NNP
cord-001835-0s7ok4uw	1514	3	1	1	CD
cord-001835-0s7ok4uw	1514	4	,	,	,
cord-001835-0s7ok4uw	1514	5	Audrey	Audrey	NNP
cord-001835-0s7ok4uw	1514	6	Toinon	Toinon	NNP
cord-001835-0s7ok4uw	1514	7	1	1	CD
cord-001835-0s7ok4uw	1514	8	,	,	,
cord-001835-0s7ok4uw	1514	9	Nadege	Nadege	NNP
cord-001835-0s7ok4uw	1514	10	Moreno	Moreno	NNP
cord-001835-0s7ok4uw	1514	11	1	1	CD
cord-001835-0s7ok4uw	1515	1	,	,	,
cord-001835-0s7ok4uw	1515	2	Marie	Marie	NNP
cord-001835-0s7ok4uw	1515	3	Claire	Claire	NNP
cord-001835-0s7ok4uw	1515	4	Nicola€	Nicola€	NNP
cord-001835-0s7ok4uw	1516	1	ı	ı	LS
cord-001835-0s7ok4uw	1516	2	1	1	CD
cord-001835-0s7ok4uw	1516	3	Rabies	Rabies	NNP
cord-001835-0s7ok4uw	1516	4	remains	remain	VBZ
cord-001835-0s7ok4uw	1516	5	an	an	DT
cord-001835-0s7ok4uw	1516	6	important	important	JJ
cord-001835-0s7ok4uw	1516	7	worldwide	worldwide	JJ
cord-001835-0s7ok4uw	1516	8	health	health	NN
cord-001835-0s7ok4uw	1516	9	problem	problem	NN
cord-001835-0s7ok4uw	1516	10	that	that	WDT
cord-001835-0s7ok4uw	1516	11	causes	cause	VBZ
cord-001835-0s7ok4uw	1516	12	a	a	DT
cord-001835-0s7ok4uw	1516	13	fatal	fatal	JJ
cord-001835-0s7ok4uw	1516	14	encephalomyelitis	encephalomyelitis	NN
cord-001835-0s7ok4uw	1516	15	[	[	-LRB-
cord-001835-0s7ok4uw	1516	16	1	1	CD
cord-001835-0s7ok4uw	1516	17	]	]	-RRB-
cord-001835-0s7ok4uw	1516	18	.	.	.
cord-001835-0s7ok4uw	1517	1	Currently	currently	RB
cord-001835-0s7ok4uw	1517	2	,	,	,
cord-001835-0s7ok4uw	1517	3	rabies	rabie	NNS
cord-001835-0s7ok4uw	1517	4	in	in	IN
cord-001835-0s7ok4uw	1517	5	humans	human	NNS
cord-001835-0s7ok4uw	1517	6	is	be	VBZ
cord-001835-0s7ok4uw	1517	7	under	under	IN
cord-001835-0s7ok4uw	1517	8	control	control	NN
cord-001835-0s7ok4uw	1517	9	in	in	IN
cord-001835-0s7ok4uw	1517	10	Europe	Europe	NNP
cord-001835-0s7ok4uw	1517	11	and	and	CC
cord-001835-0s7ok4uw	1517	12	North	North	NNP
cord-001835-0s7ok4uw	1517	13	America	America	NNP
cord-001835-0s7ok4uw	1517	14	following	follow	VBG
cord-001835-0s7ok4uw	1517	15	the	the	DT
cord-001835-0s7ok4uw	1517	16	use	use	NN
cord-001835-0s7ok4uw	1517	17	of	of	IN
cord-001835-0s7ok4uw	1517	18	efficient	efficient	JJ
cord-001835-0s7ok4uw	1517	19	vaccines	vaccine	NNS
cord-001835-0s7ok4uw	1517	20	for	for	IN
cord-001835-0s7ok4uw	1517	21	dogs	dog	NNS
cord-001835-0s7ok4uw	1517	22	and	and	CC
cord-001835-0s7ok4uw	1517	23	wild	wild	JJ
cord-001835-0s7ok4uw	1517	24	animals	animal	NNS
cord-001835-0s7ok4uw	1517	25	.	.	.
cord-001835-0s7ok4uw	1518	1	However	however	RB
cord-001835-0s7ok4uw	1518	2	,	,	,
cord-001835-0s7ok4uw	1518	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	1518	4	still	still	RB
cord-001835-0s7ok4uw	1518	5	kills	kill	VBZ
cord-001835-0s7ok4uw	1518	6	more	more	JJR
cord-001835-0s7ok4uw	1518	7	than	than	IN
cord-001835-0s7ok4uw	1518	8	55,000	55,000	CD
cord-001835-0s7ok4uw	1518	9	people	people	NNS
cord-001835-0s7ok4uw	1518	10	every	every	DT
cord-001835-0s7ok4uw	1518	11	year	year	NN
cord-001835-0s7ok4uw	1518	12	mainly	mainly	RB
cord-001835-0s7ok4uw	1518	13	in	in	IN
cord-001835-0s7ok4uw	1518	14	Africa	Africa	NNP
cord-001835-0s7ok4uw	1518	15	and	and	CC
cord-001835-0s7ok4uw	1518	16	Asia	Asia	NNP
cord-001835-0s7ok4uw	1518	17	[	[	-LRB-
cord-001835-0s7ok4uw	1518	18	2	2	CD
cord-001835-0s7ok4uw	1518	19	]	]	-RRB-
cord-001835-0s7ok4uw	1518	20	.	.	.
cord-001835-0s7ok4uw	1519	1	Human	human	JJ
cord-001835-0s7ok4uw	1519	2	vaccination	vaccination	NN
cord-001835-0s7ok4uw	1519	3	prevents	prevent	VBZ
cord-001835-0s7ok4uw	1519	4	infection	infection	NN
cord-001835-0s7ok4uw	1519	5	with	with	IN
cord-001835-0s7ok4uw	1519	6	very	very	RB
cord-001835-0s7ok4uw	1519	7	high	high	JJ
cord-001835-0s7ok4uw	1519	8	efficacy	efficacy	NN
cord-001835-0s7ok4uw	1519	9	.	.	.
cord-001835-0s7ok4uw	1520	1	The	the	DT
cord-001835-0s7ok4uw	1520	2	vaccine	vaccine	NN
cord-001835-0s7ok4uw	1520	3	contains	contain	VBZ
cord-001835-0s7ok4uw	1520	4	an	an	DT
cord-001835-0s7ok4uw	1520	5	inactivated	inactivate	VBN
cord-001835-0s7ok4uw	1520	6	RABV	rabv	NN
cord-001835-0s7ok4uw	1520	7	produced	produce	VBN
cord-001835-0s7ok4uw	1520	8	on	on	IN
cord-001835-0s7ok4uw	1520	9	Vero	Vero	NNP
cord-001835-0s7ok4uw	1520	10	cells	cell	NNS
cord-001835-0s7ok4uw	1520	11	.	.	.
cord-001835-0s7ok4uw	1521	1	RABV	RABV	NNP
cord-001835-0s7ok4uw	1521	2	is	be	VBZ
cord-001835-0s7ok4uw	1521	3	an	an	DT
cord-001835-0s7ok4uw	1521	4	enveloped	envelop	VBN
cord-001835-0s7ok4uw	1521	5	,	,	,
cord-001835-0s7ok4uw	1521	6	negative	negative	JJ
cord-001835-0s7ok4uw	1521	7	single	single	JJ
cord-001835-0s7ok4uw	1521	8	stranded	strand	VBN
cord-001835-0s7ok4uw	1521	9	RNA	RNA	NNP
cord-001835-0s7ok4uw	1521	10	virus	virus	NN
cord-001835-0s7ok4uw	1521	11	which	which	WDT
cord-001835-0s7ok4uw	1521	12	encodes	encode	VBZ
cord-001835-0s7ok4uw	1521	13	five	five	CD
cord-001835-0s7ok4uw	1521	14	proteins	protein	NNS
cord-001835-0s7ok4uw	1521	15	,	,	,
cord-001835-0s7ok4uw	1521	16	namely	namely	RB
cord-001835-0s7ok4uw	1521	17	the	the	DT
cord-001835-0s7ok4uw	1521	18	nucleoprotein	nucleoprotein	NNP
cord-001835-0s7ok4uw	1521	19	(	(	-LRB-
cord-001835-0s7ok4uw	1521	20	N	N	NNP
cord-001835-0s7ok4uw	1521	21	)	)	-RRB-
cord-001835-0s7ok4uw	1521	22	,	,	,
cord-001835-0s7ok4uw	1521	23	the	the	DT
cord-001835-0s7ok4uw	1521	24	phosphoprotein	phosphoprotein	NN
cord-001835-0s7ok4uw	1521	25	(	(	-LRB-
cord-001835-0s7ok4uw	1521	26	P	p	NN
cord-001835-0s7ok4uw	1521	27	)	)	-RRB-
cord-001835-0s7ok4uw	1521	28	,	,	,
cord-001835-0s7ok4uw	1521	29	the	the	DT
cord-001835-0s7ok4uw	1521	30	matrix	matrix	NN
cord-001835-0s7ok4uw	1521	31	protein	protein	NN
cord-001835-0s7ok4uw	1521	32	(	(	-LRB-
cord-001835-0s7ok4uw	1521	33	M	M	NNP
cord-001835-0s7ok4uw	1521	34	)	)	-RRB-
cord-001835-0s7ok4uw	1521	35	,	,	,
cord-001835-0s7ok4uw	1521	36	the	the	DT
cord-001835-0s7ok4uw	1521	37	glycoprotein	glycoprotein	NN
cord-001835-0s7ok4uw	1521	38	(	(	-LRB-
cord-001835-0s7ok4uw	1521	39	G	G	NNP
cord-001835-0s7ok4uw	1521	40	)	)	-RRB-
cord-001835-0s7ok4uw	1521	41	,	,	,
cord-001835-0s7ok4uw	1521	42	and	and	CC
cord-001835-0s7ok4uw	1521	43	the	the	DT
cord-001835-0s7ok4uw	1521	44	viral	viral	JJ
cord-001835-0s7ok4uw	1521	45	RNA	rna	NN
cord-001835-0s7ok4uw	1521	46	polymerase	polymerase	NN
cord-001835-0s7ok4uw	1521	47	(	(	-LRB-
cord-001835-0s7ok4uw	1521	48	L	l	NN
cord-001835-0s7ok4uw	1521	49	)	)	-RRB-
cord-001835-0s7ok4uw	1521	50	[	[	-LRB-
cord-001835-0s7ok4uw	1521	51	3	3	CD
cord-001835-0s7ok4uw	1521	52	]	]	-RRB-
cord-001835-0s7ok4uw	1521	53	.	.	.
cord-001835-0s7ok4uw	1522	1	The	the	DT
cord-001835-0s7ok4uw	1522	2	viral	viral	JJ
cord-001835-0s7ok4uw	1522	3	envelope	envelope	NN
cord-001835-0s7ok4uw	1522	4	is	be	VBZ
cord-001835-0s7ok4uw	1522	5	covered	cover	VBN
cord-001835-0s7ok4uw	1522	6	by	by	IN
cord-001835-0s7ok4uw	1522	7	trimer	trimer	NN
cord-001835-0s7ok4uw	1522	8	spikes	spike	NNS
cord-001835-0s7ok4uw	1522	9	of	of	IN
cord-001835-0s7ok4uw	1522	10	G	g	NN
cord-001835-0s7ok4uw	1522	11	-	-	HYPH
cord-001835-0s7ok4uw	1522	12	glycoprotein	glycoprotein	NN
cord-001835-0s7ok4uw	1522	13	which	which	WDT
cord-001835-0s7ok4uw	1522	14	is	be	VBZ
cord-001835-0s7ok4uw	1522	15	the	the	DT
cord-001835-0s7ok4uw	1522	16	most	most	RBS
cord-001835-0s7ok4uw	1522	17	significant	significant	JJ
cord-001835-0s7ok4uw	1522	18	surface	surface	NN
cord-001835-0s7ok4uw	1522	19	antigen	antigen	NN
cord-001835-0s7ok4uw	1522	20	for	for	IN
cord-001835-0s7ok4uw	1522	21	generating	generate	VBG
cord-001835-0s7ok4uw	1522	22	virus	virus	NN
cord-001835-0s7ok4uw	1522	23	-	-	HYPH
cord-001835-0s7ok4uw	1522	24	neutralizing	neutralize	VBG
cord-001835-0s7ok4uw	1522	25	antibodies	antibody	NNS
cord-001835-0s7ok4uw	1522	26	.	.	.
cord-001835-0s7ok4uw	1523	1	Here	here	RB
cord-001835-0s7ok4uw	1523	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	1523	3	illustrate	illustrate	VBP
cord-001835-0s7ok4uw	1523	4	the	the	DT
cord-001835-0s7ok4uw	1523	5	use	use	NN
cord-001835-0s7ok4uw	1523	6	of	of	IN
cord-001835-0s7ok4uw	1523	7	DSC	DSC	NNP
cord-001835-0s7ok4uw	1523	8	(	(	-LRB-
cord-001835-0s7ok4uw	1523	9	Differential	differential	JJ
cord-001835-0s7ok4uw	1523	10	Scanning	scanning	NN
cord-001835-0s7ok4uw	1523	11	Calorimetry	Calorimetry	NNP
cord-001835-0s7ok4uw	1523	12	)	)	-RRB-
cord-001835-0s7ok4uw	1523	13	to	to	TO
cord-001835-0s7ok4uw	1523	14	identify	identify	VB
cord-001835-0s7ok4uw	1523	15	structural	structural	JJ
cord-001835-0s7ok4uw	1523	16	domains	domain	NNS
cord-001835-0s7ok4uw	1523	17	or	or	CC
cord-001835-0s7ok4uw	1523	18	proteins	protein	NNS
cord-001835-0s7ok4uw	1523	19	involved	involve	VBN
cord-001835-0s7ok4uw	1523	20	in	in	IN
cord-001835-0s7ok4uw	1523	21	thermal	thermal	JJ
cord-001835-0s7ok4uw	1523	22	transitions	transition	NNS
cord-001835-0s7ok4uw	1523	23	.	.	.
cord-001835-0s7ok4uw	1524	1	The	the	DT
cord-001835-0s7ok4uw	1524	2	DSC	DSC	NNP
cord-001835-0s7ok4uw	1524	3	thermogram	thermogram	NN
cord-001835-0s7ok4uw	1524	4	for	for	IN
cord-001835-0s7ok4uw	1524	5	intact	intact	JJ
cord-001835-0s7ok4uw	1524	6	Beta	beta	NN
cord-001835-0s7ok4uw	1524	7	-	-	HYPH
cord-001835-0s7ok4uw	1524	8	propiolactone	propiolactone	NN
cord-001835-0s7ok4uw	1524	9	inactivated	inactivate	VBN
cord-001835-0s7ok4uw	1524	10	RABV	RABV	NNP
cord-001835-0s7ok4uw	1524	11	samples	sample	NNS
cord-001835-0s7ok4uw	1524	12	in	in	IN
cord-001835-0s7ok4uw	1524	13	PBS	PBS	NNP
cord-001835-0s7ok4uw	1524	14	buffer	buffer	NN
cord-001835-0s7ok4uw	1525	1	reveals	reveal	VBZ
cord-001835-0s7ok4uw	1525	2	two	two	CD
cord-001835-0s7ok4uw	1525	3	major	major	JJ
cord-001835-0s7ok4uw	1525	4	thermal	thermal	JJ
cord-001835-0s7ok4uw	1525	5	transitions	transition	NNS
cord-001835-0s7ok4uw	1525	6	with	with	IN
cord-001835-0s7ok4uw	1525	7	a	a	DT
cord-001835-0s7ok4uw	1525	8	Tm	Tm	NNP
cord-001835-0s7ok4uw	1525	9	respectively	respectively	RB
cord-001835-0s7ok4uw	1525	10	at	at	IN
cord-001835-0s7ok4uw	1525	11	618C	618c	CD
cord-001835-0s7ok4uw	1526	1	and	and	CC
cord-001835-0s7ok4uw	1526	2	718C.	718c.	CD
cord-001835-0s7ok4uw	1527	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1527	2	have	have	VBP
cord-001835-0s7ok4uw	1527	3	initially	initially	RB
cord-001835-0s7ok4uw	1527	4	focused	focus	VBN
cord-001835-0s7ok4uw	1527	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1527	6	investigations	investigation	NNS
cord-001835-0s7ok4uw	1527	7	on	on	IN
cord-001835-0s7ok4uw	1527	8	one	one	CD
cord-001835-0s7ok4uw	1527	9	of	of	IN
cord-001835-0s7ok4uw	1527	10	the	the	DT
cord-001835-0s7ok4uw	1527	11	major	major	JJ
cord-001835-0s7ok4uw	1527	12	proteins	protein	NNS
cord-001835-0s7ok4uw	1527	13	encode	encode	VBP
cord-001835-0s7ok4uw	1527	14	in	in	IN
cord-001835-0s7ok4uw	1527	15	RABV	RABV	NNP
cord-001835-0s7ok4uw	1527	16	,	,	,
cord-001835-0s7ok4uw	1527	17	Glycoprotein	Glycoprotein	NNP
cord-001835-0s7ok4uw	1527	18	G	G	NNP
cord-001835-0s7ok4uw	1527	19	[	[	-LRB-
cord-001835-0s7ok4uw	1527	20	4	4	CD
cord-001835-0s7ok4uw	1527	21	]	]	-RRB-
cord-001835-0s7ok4uw	1527	22	.	.	.
cord-001835-0s7ok4uw	1528	1	Glycoprotein	Glycoprotein	NNP
cord-001835-0s7ok4uw	1528	2	G	g	NN
cord-001835-0s7ok4uw	1528	3	contains	contain	VBZ
cord-001835-0s7ok4uw	1528	4	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	1528	5	bridges	bridge	NNS
cord-001835-0s7ok4uw	1528	6	on	on	IN
cord-001835-0s7ok4uw	1528	7	the	the	DT
cord-001835-0s7ok4uw	1528	8	ectodomain	ectodomain	NN
cord-001835-0s7ok4uw	1528	9	[	[	-LRB-
cord-001835-0s7ok4uw	1528	10	6	6	CD
cord-001835-0s7ok4uw	1528	11	]	]	-RRB-
cord-001835-0s7ok4uw	1528	12	,	,	,
cord-001835-0s7ok4uw	1528	13	is	be	VBZ
cord-001835-0s7ok4uw	1528	14	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	1528	15	to	to	IN
cord-001835-0s7ok4uw	1528	16	Bromelain	bromelain	NN
cord-001835-0s7ok4uw	1528	17	cleavage	cleavage	NN
cord-001835-0s7ok4uw	1528	18	[	[	-LRB-
cord-001835-0s7ok4uw	1528	19	5	5	CD
cord-001835-0s7ok4uw	1528	20	]	]	-RRB-
cord-001835-0s7ok4uw	1528	21	and	and	CC
cord-001835-0s7ok4uw	1528	22	shows	show	VBZ
cord-001835-0s7ok4uw	1528	23	reversible	reversible	JJ
cord-001835-0s7ok4uw	1528	24	conformation	conformation	NN
cord-001835-0s7ok4uw	1528	25	changes	change	NNS
cord-001835-0s7ok4uw	1528	26	at	at	IN
cord-001835-0s7ok4uw	1528	27	low	low	JJ
cord-001835-0s7ok4uw	1528	28	pH	pH	.
cord-001835-0s7ok4uw	1528	29	[	[	-LRB-
cord-001835-0s7ok4uw	1528	30	7	7	CD
cord-001835-0s7ok4uw	1528	31	]	]	-RRB-
cord-001835-0s7ok4uw	1528	32	.	.	.
cord-001835-0s7ok4uw	1529	1	Considering	consider	VBG
cord-001835-0s7ok4uw	1529	2	these	these	DT
cord-001835-0s7ok4uw	1529	3	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	1529	4	,	,	,
cord-001835-0s7ok4uw	1529	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1529	6	results	result	NNS
cord-001835-0s7ok4uw	1529	7	provide	provide	VBP
cord-001835-0s7ok4uw	1529	8	evidence	evidence	NN
cord-001835-0s7ok4uw	1529	9	on	on	IN
cord-001835-0s7ok4uw	1529	10	the	the	DT
cord-001835-0s7ok4uw	1529	11	identity	identity	NN
cord-001835-0s7ok4uw	1529	12	of	of	IN
cord-001835-0s7ok4uw	1529	13	one	one	CD
cord-001835-0s7ok4uw	1529	14	thermal	thermal	JJ
cord-001835-0s7ok4uw	1529	15	transition	transition	NN
cord-001835-0s7ok4uw	1529	16	observed	observe	VBN
cord-001835-0s7ok4uw	1529	17	by	by	IN
cord-001835-0s7ok4uw	1529	18	DSC	DSC	NNP
cord-001835-0s7ok4uw	1529	19	.	.	.
cord-001835-0s7ok4uw	1530	1	Keywords	keyword	NNS
cord-001835-0s7ok4uw	1530	2	:	:	:
cord-001835-0s7ok4uw	1531	1	rabies	rabies	NNP
cord-001835-0s7ok4uw	1531	2	virus	virus	NN
cord-001835-0s7ok4uw	1531	3	,	,	,
cord-001835-0s7ok4uw	1531	4	Differential	differential	JJ
cord-001835-0s7ok4uw	1531	5	Scanning	Scanning	NNP
cord-001835-0s7ok4uw	1531	6	Calorimetry	Calorimetry	NNP
cord-001835-0s7ok4uw	1531	7	,	,	,
cord-001835-0s7ok4uw	1531	8	protein	protein	NN
cord-001835-0s7ok4uw	1531	9	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1531	10	Domain	domain	NN
cord-001835-0s7ok4uw	1531	11	swapping	swapping	NN
cord-001835-0s7ok4uw	1531	12	of	of	IN
cord-001835-0s7ok4uw	1531	13	the	the	DT
cord-001835-0s7ok4uw	1531	14	DNA	dna	NN
cord-001835-0s7ok4uw	1531	15	-	-	HYPH
cord-001835-0s7ok4uw	1531	16	binding	bind	VBG
cord-001835-0s7ok4uw	1531	17	domain	domain	NN
cord-001835-0s7ok4uw	1531	18	of	of	IN
cord-001835-0s7ok4uw	1531	19	human	human	JJ
cord-001835-0s7ok4uw	1531	20	FoxP1	FoxP1	NNP
cord-001835-0s7ok4uw	1531	21	is	be	VBZ
cord-001835-0s7ok4uw	1531	22	facilitated	facilitate	VBN
cord-001835-0s7ok4uw	1531	23	by	by	IN
cord-001835-0s7ok4uw	1531	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1531	25	low	low	JJ
cord-001835-0s7ok4uw	1531	26	folding	folding	NN
cord-001835-0s7ok4uw	1531	27	stability	stability	NN
cord-001835-0s7ok4uw	1532	1	Exequiel	Exequiel	NNP
cord-001835-0s7ok4uw	1532	2	Medina	Medina	NNP
cord-001835-0s7ok4uw	1532	3	,	,	,
cord-001835-0s7ok4uw	1532	4	Sandro	Sandro	NNP
cord-001835-0s7ok4uw	1532	5	L.	L.	NNP
cord-001835-0s7ok4uw	1532	6	Valenzuela	Valenzuela	NNP
cord-001835-0s7ok4uw	1532	7	,	,	,
cord-001835-0s7ok4uw	1532	8	Crist	Crist	NNP
cord-001835-0s7ok4uw	1532	9	obal	obal	NNP
cord-001835-0s7ok4uw	1532	10	C	C	NNP
cord-001835-0s7ok4uw	1532	11	ordova	ordova	NNP
cord-001835-0s7ok4uw	1532	12	,	,	,
cord-001835-0s7ok4uw	1532	13	C	C	NNP
cord-001835-0s7ok4uw	1532	14	esar	esar	NN
cord-001835-0s7ok4uw	1532	15	A.	a.	NN
cord-001835-0s7ok4uw	1532	16	Ram	ram	NN
cord-001835-0s7ok4uw	1532	17	ırez	ırez	NN
cord-001835-0s7ok4uw	1532	18	-	-	HYPH
cord-001835-0s7ok4uw	1532	19	Sarmiento	Sarmiento	NNP
cord-001835-0s7ok4uw	1532	20	and	and	CC
cord-001835-0s7ok4uw	1532	21	Jorge	Jorge	NNP
cord-001835-0s7ok4uw	1532	22	Babul	Babul	NNP
cord-001835-0s7ok4uw	1532	23	Departamento	Departamento	NNP
cord-001835-0s7ok4uw	1532	24	de	de	NNP
cord-001835-0s7ok4uw	1532	25	Biolog	Biolog	NNP
cord-001835-0s7ok4uw	1532	26	ıa	ıa	NNS
cord-001835-0s7ok4uw	1532	27	,	,	,
cord-001835-0s7ok4uw	1532	28	Facultad	Facultad	NNP
cord-001835-0s7ok4uw	1532	29	de	de	NNP
cord-001835-0s7ok4uw	1532	30	Ciencias	Ciencias	NNP
cord-001835-0s7ok4uw	1532	31	,	,	,
cord-001835-0s7ok4uw	1532	32	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	1532	33	de	de	NNP
cord-001835-0s7ok4uw	1532	34	Chile	Chile	NNP
cord-001835-0s7ok4uw	1532	35	,	,	,
cord-001835-0s7ok4uw	1532	36	Santiago	Santiago	NNP
cord-001835-0s7ok4uw	1532	37	,	,	,
cord-001835-0s7ok4uw	1532	38	Chile	Chile	NNP
cord-001835-0s7ok4uw	1532	39	Protein	Protein	NNP
cord-001835-0s7ok4uw	1532	40	folding	folding	NN
cord-001835-0s7ok4uw	1532	41	and	and	CC
cord-001835-0s7ok4uw	1532	42	dimerization	dimerization	NN
cord-001835-0s7ok4uw	1532	43	(	(	-LRB-
cord-001835-0s7ok4uw	1532	44	or	or	CC
cord-001835-0s7ok4uw	1532	45	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	1532	46	)	)	-RRB-
cord-001835-0s7ok4uw	1532	47	are	be	VBP
cord-001835-0s7ok4uw	1532	48	biologically	biologically	RB
cord-001835-0s7ok4uw	1532	49	relevant	relevant	JJ
cord-001835-0s7ok4uw	1532	50	processes	process	NNS
cord-001835-0s7ok4uw	1532	51	when	when	WRB
cord-001835-0s7ok4uw	1532	52	reaching	reach	VBG
cord-001835-0s7ok4uw	1532	53	the	the	DT
cord-001835-0s7ok4uw	1532	54	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	1532	55	structure	structure	NN
cord-001835-0s7ok4uw	1532	56	is	be	VBZ
cord-001835-0s7ok4uw	1532	57	required	require	VBN
cord-001835-0s7ok4uw	1532	58	for	for	IN
cord-001835-0s7ok4uw	1532	59	function	function	NN
cord-001835-0s7ok4uw	1532	60	.	.	.
cord-001835-0s7ok4uw	1533	1	Proteins	protein	NNS
cord-001835-0s7ok4uw	1533	2	that	that	WDT
cord-001835-0s7ok4uw	1533	3	form	form	VBP
cord-001835-0s7ok4uw	1533	4	dimers	dimer	NNS
cord-001835-0s7ok4uw	1533	5	by	by	IN
cord-001835-0s7ok4uw	1533	6	exchanging	exchange	VBG
cord-001835-0s7ok4uw	1533	7	segments	segment	NNS
cord-001835-0s7ok4uw	1533	8	or	or	CC
cord-001835-0s7ok4uw	1533	9	domains	domain	NNS
cord-001835-0s7ok4uw	1533	10	of	of	IN
cord-001835-0s7ok4uw	1533	11	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1533	12	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	1533	13	structure	structure	NN
cord-001835-0s7ok4uw	1533	14	with	with	IN
cord-001835-0s7ok4uw	1533	15	another	another	DT
cord-001835-0s7ok4uw	1533	16	subunit	subunit	NN
cord-001835-0s7ok4uw	1533	17	,	,	,
cord-001835-0s7ok4uw	1533	18	the	the	DT
cord-001835-0s7ok4uw	1533	19	so	so	RB
cord-001835-0s7ok4uw	1533	20	-	-	HYPH
cord-001835-0s7ok4uw	1533	21	called	call	VBN
cord-001835-0s7ok4uw	1533	22	domain	domain	NN
cord-001835-0s7ok4uw	1533	23	swapping	swapping	NN
cord-001835-0s7ok4uw	1533	24	phenomenon	phenomenon	NN
cord-001835-0s7ok4uw	1533	25	,	,	,
cord-001835-0s7ok4uw	1533	26	are	be	VBP
cord-001835-0s7ok4uw	1533	27	examples	example	NNS
cord-001835-0s7ok4uw	1533	28	where	where	WRB
cord-001835-0s7ok4uw	1533	29	folding	folding	NN
cord-001835-0s7ok4uw	1533	30	and	and	CC
cord-001835-0s7ok4uw	1533	31	dimerization	dimerization	NN
cord-001835-0s7ok4uw	1533	32	are	be	VBP
cord-001835-0s7ok4uw	1533	33	tightly	tightly	RB
cord-001835-0s7ok4uw	1533	34	concerted	concert	VBN
cord-001835-0s7ok4uw	1533	35	processes	process	NNS
cord-001835-0s7ok4uw	1533	36	.	.	.
cord-001835-0s7ok4uw	1534	1	Previous	previous	JJ
cord-001835-0s7ok4uw	1534	2	studies	study	NNS
cord-001835-0s7ok4uw	1534	3	on	on	IN
cord-001835-0s7ok4uw	1534	4	domain	domain	NN
cord-001835-0s7ok4uw	1534	5	swapping	swapping	NN
cord-001835-0s7ok4uw	1534	6	proteins	protein	NNS
cord-001835-0s7ok4uw	1534	7	,	,	,
cord-001835-0s7ok4uw	1534	8	such	such	JJ
cord-001835-0s7ok4uw	1534	9	as	as	IN
cord-001835-0s7ok4uw	1534	10	p13suc1	p13suc1	NNP
cord-001835-0s7ok4uw	1534	11	and	and	CC
cord-001835-0s7ok4uw	1534	12	diphtheria	diphtheria	NN
cord-001835-0s7ok4uw	1534	13	toxin	toxin	NN
cord-001835-0s7ok4uw	1534	14	,	,	,
cord-001835-0s7ok4uw	1534	15	have	have	VBP
cord-001835-0s7ok4uw	1534	16	shown	show	VBN
cord-001835-0s7ok4uw	1534	17	that	that	IN
cord-001835-0s7ok4uw	1534	18	,	,	,
cord-001835-0s7ok4uw	1534	19	in	in	IN
cord-001835-0s7ok4uw	1534	20	general	general	JJ
cord-001835-0s7ok4uw	1534	21	,	,	,
cord-001835-0s7ok4uw	1534	22	a	a	DT
cord-001835-0s7ok4uw	1534	23	high	high	JJ
cord-001835-0s7ok4uw	1534	24	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1534	25	barrier	barrier	NN
cord-001835-0s7ok4uw	1534	26	separates	separate	VBZ
cord-001835-0s7ok4uw	1534	27	monomers	monomer	NNS
cord-001835-0s7ok4uw	1534	28	and	and	CC
cord-001835-0s7ok4uw	1534	29	domain	domain	NN
cord-001835-0s7ok4uw	1534	30	swapped	swap	VBN
cord-001835-0s7ok4uw	1534	31	dimers	dimer	NNS
cord-001835-0s7ok4uw	1534	32	,	,	,
cord-001835-0s7ok4uw	1534	33	and	and	CC
cord-001835-0s7ok4uw	1534	34	that	that	IN
cord-001835-0s7ok4uw	1534	35	this	this	DT
cord-001835-0s7ok4uw	1534	36	barrier	barrier	NN
cord-001835-0s7ok4uw	1534	37	can	can	MD
cord-001835-0s7ok4uw	1534	38	be	be	VB
cord-001835-0s7ok4uw	1534	39	lowered	lower	VBN
cord-001835-0s7ok4uw	1534	40	by	by	IN
cord-001835-0s7ok4uw	1534	41	promoting	promote	VBG
cord-001835-0s7ok4uw	1534	42	protein	protein	NN
cord-001835-0s7ok4uw	1534	43	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1534	44	and	and	CC
cord-001835-0s7ok4uw	1534	45	refolding	refolde	VBG
cord-001835-0s7ok4uw	1534	46	at	at	IN
cord-001835-0s7ok4uw	1534	47	high	high	JJ
cord-001835-0s7ok4uw	1534	48	protein	protein	NN
cord-001835-0s7ok4uw	1534	49	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1534	50	,	,	,
cord-001835-0s7ok4uw	1534	51	thus	thus	RB
cord-001835-0s7ok4uw	1534	52	favoring	favor	VBG
cord-001835-0s7ok4uw	1534	53	the	the	DT
cord-001835-0s7ok4uw	1534	54	swapped	swap	VBN
cord-001835-0s7ok4uw	1534	55	oligomer	oligomer	NNP
cord-001835-0s7ok4uw	1534	56	.	.	.
cord-001835-0s7ok4uw	1535	1	Recent	recent	JJ
cord-001835-0s7ok4uw	1535	2	crystal	crystal	NN
cord-001835-0s7ok4uw	1535	3	structures	structure	NNS
cord-001835-0s7ok4uw	1535	4	of	of	IN
cord-001835-0s7ok4uw	1535	5	the	the	DT
cord-001835-0s7ok4uw	1535	6	DNA	dna	NN
cord-001835-0s7ok4uw	1535	7	-	-	HYPH
cord-001835-0s7ok4uw	1535	8	binding	bind	VBG
cord-001835-0s7ok4uw	1535	9	domain	domain	NN
cord-001835-0s7ok4uw	1535	10	of	of	IN
cord-001835-0s7ok4uw	1535	11	several	several	JJ
cord-001835-0s7ok4uw	1535	12	human	human	JJ
cord-001835-0s7ok4uw	1535	13	forkhead	forkhead	NNP
cord-001835-0s7ok4uw	1535	14	box	box	NNP
cord-001835-0s7ok4uw	1535	15	(	(	-LRB-
cord-001835-0s7ok4uw	1535	16	Fox	Fox	NNP
cord-001835-0s7ok4uw	1535	17	)	)	-RRB-
cord-001835-0s7ok4uw	1535	18	proteins	protein	NNS
cord-001835-0s7ok4uw	1535	19	have	have	VBP
cord-001835-0s7ok4uw	1535	20	shown	show	VBN
cord-001835-0s7ok4uw	1535	21	that	that	IN
cord-001835-0s7ok4uw	1535	22	the	the	DT
cord-001835-0s7ok4uw	1535	23	P	p	NN
cord-001835-0s7ok4uw	1535	24	subfamily	subfamily	NN
cord-001835-0s7ok4uw	1535	25	of	of	IN
cord-001835-0s7ok4uw	1535	26	these	these	DT
cord-001835-0s7ok4uw	1535	27	transcription	transcription	NN
cord-001835-0s7ok4uw	1535	28	factors	factor	NNS
cord-001835-0s7ok4uw	1535	29	(	(	-LRB-
cord-001835-0s7ok4uw	1535	30	FoxP	FoxP	NNP
cord-001835-0s7ok4uw	1535	31	)	)	-RRB-
cord-001835-0s7ok4uw	1535	32	can	can	MD
cord-001835-0s7ok4uw	1535	33	form	form	VB
cord-001835-0s7ok4uw	1535	34	swapped	swap	VBN
cord-001835-0s7ok4uw	1535	35	dimers	dimer	NNS
cord-001835-0s7ok4uw	1535	36	.	.	.
cord-001835-0s7ok4uw	1536	1	The	the	DT
cord-001835-0s7ok4uw	1536	2	human	human	JJ
cord-001835-0s7ok4uw	1536	3	FoxP	FoxP	NNP
cord-001835-0s7ok4uw	1536	4	proteins	protein	NNS
cord-001835-0s7ok4uw	1536	5	are	be	VBP
cord-001835-0s7ok4uw	1536	6	interesting	interesting	JJ
cord-001835-0s7ok4uw	1536	7	models	model	NNS
cord-001835-0s7ok4uw	1536	8	of	of	IN
cord-001835-0s7ok4uw	1536	9	domain	domain	NN
cord-001835-0s7ok4uw	1536	10	swapping	swapping	NN
cord-001835-0s7ok4uw	1536	11	,	,	,
cord-001835-0s7ok4uw	1536	12	because	because	IN
cord-001835-0s7ok4uw	1536	13	mutations	mutation	NNS
cord-001835-0s7ok4uw	1536	14	of	of	IN
cord-001835-0s7ok4uw	1536	15	the	the	DT
cord-001835-0s7ok4uw	1536	16	DNA	dna	NN
cord-001835-0s7ok4uw	1536	17	-	-	HYPH
cord-001835-0s7ok4uw	1536	18	binding	bind	VBG
cord-001835-0s7ok4uw	1536	19	domain	domain	NN
cord-001835-0s7ok4uw	1536	20	of	of	IN
cord-001835-0s7ok4uw	1536	21	these	these	DT
cord-001835-0s7ok4uw	1536	22	proteins	protein	NNS
cord-001835-0s7ok4uw	1536	23	are	be	VBP
cord-001835-0s7ok4uw	1536	24	linked	link	VBN
cord-001835-0s7ok4uw	1536	25	to	to	IN
cord-001835-0s7ok4uw	1536	26	diverse	diverse	JJ
cord-001835-0s7ok4uw	1536	27	inherited	inherit	VBN
cord-001835-0s7ok4uw	1536	28	disorders	disorder	NNS
cord-001835-0s7ok4uw	1536	29	in	in	IN
cord-001835-0s7ok4uw	1536	30	humans	human	NNS
cord-001835-0s7ok4uw	1536	31	,	,	,
cord-001835-0s7ok4uw	1536	32	such	such	JJ
cord-001835-0s7ok4uw	1536	33	as	as	IN
cord-001835-0s7ok4uw	1536	34	IPEX	IPEX	NNP
cord-001835-0s7ok4uw	1536	35	and	and	CC
cord-001835-0s7ok4uw	1536	36	language	language	NN
cord-001835-0s7ok4uw	1536	37	deficits	deficit	NNS
cord-001835-0s7ok4uw	1536	38	,	,	,
cord-001835-0s7ok4uw	1536	39	and	and	CC
cord-001835-0s7ok4uw	1536	40	some	some	DT
cord-001835-0s7ok4uw	1536	41	of	of	IN
cord-001835-0s7ok4uw	1536	42	these	these	DT
cord-001835-0s7ok4uw	1536	43	mutations	mutation	NNS
cord-001835-0s7ok4uw	1536	44	are	be	VBP
cord-001835-0s7ok4uw	1536	45	located	locate	VBN
cord-001835-0s7ok4uw	1536	46	in	in	IN
cord-001835-0s7ok4uw	1536	47	the	the	DT
cord-001835-0s7ok4uw	1536	48	hinge	hinge	NN
cord-001835-0s7ok4uw	1536	49	region	region	NN
cord-001835-0s7ok4uw	1536	50	that	that	WDT
cord-001835-0s7ok4uw	1536	51	connects	connect	VBZ
cord-001835-0s7ok4uw	1536	52	the	the	DT
cord-001835-0s7ok4uw	1536	53	exchanged	exchange	VBN
cord-001835-0s7ok4uw	1536	54	segment	segment	NN
cord-001835-0s7ok4uw	1536	55	with	with	IN
cord-001835-0s7ok4uw	1536	56	the	the	DT
cord-001835-0s7ok4uw	1536	57	rest	rest	NN
cord-001835-0s7ok4uw	1536	58	of	of	IN
cord-001835-0s7ok4uw	1536	59	the	the	DT
cord-001835-0s7ok4uw	1536	60	protein	protein	NN
cord-001835-0s7ok4uw	1536	61	.	.	.
cord-001835-0s7ok4uw	1537	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	1537	2	,	,	,
cord-001835-0s7ok4uw	1537	3	FoxP1	FoxP1	NNP
cord-001835-0s7ok4uw	1537	4	and	and	CC
cord-001835-0s7ok4uw	1537	5	FoxP2	FoxP2	NNP
cord-001835-0s7ok4uw	1537	6	have	have	VBP
cord-001835-0s7ok4uw	1537	7	been	be	VBN
cord-001835-0s7ok4uw	1537	8	described	describe	VBN
cord-001835-0s7ok4uw	1537	9	to	to	TO
cord-001835-0s7ok4uw	1537	10	reach	reach	VB
cord-001835-0s7ok4uw	1537	11	monomer	monomer	NN
cord-001835-0s7ok4uw	1537	12	-	-	HYPH
cord-001835-0s7ok4uw	1537	13	dimer	dimer	NN
cord-001835-0s7ok4uw	1537	14	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	1537	15	in	in	IN
cord-001835-0s7ok4uw	1537	16	solution	solution	NN
cord-001835-0s7ok4uw	1537	17	after	after	IN
cord-001835-0s7ok4uw	1537	18	hours	hour	NNS
cord-001835-0s7ok4uw	1537	19	of	of	IN
cord-001835-0s7ok4uw	1537	20	incubation	incubation	NN
cord-001835-0s7ok4uw	1537	21	,	,	,
cord-001835-0s7ok4uw	1537	22	suggesting	suggest	VBG
cord-001835-0s7ok4uw	1537	23	that	that	IN
cord-001835-0s7ok4uw	1537	24	a	a	DT
cord-001835-0s7ok4uw	1537	25	low	low	JJ
cord-001835-0s7ok4uw	1537	26	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1537	27	barrier	barrier	NN
cord-001835-0s7ok4uw	1537	28	separates	separate	VBZ
cord-001835-0s7ok4uw	1537	29	both	both	DT
cord-001835-0s7ok4uw	1537	30	species	specie	NNS
cord-001835-0s7ok4uw	1537	31	.	.	.
cord-001835-0s7ok4uw	1538	1	Using	use	VBG
cord-001835-0s7ok4uw	1538	2	FoxP1	FoxP1	NNP
cord-001835-0s7ok4uw	1538	3	as	as	IN
cord-001835-0s7ok4uw	1538	4	a	a	DT
cord-001835-0s7ok4uw	1538	5	model	model	NN
cord-001835-0s7ok4uw	1538	6	of	of	IN
cord-001835-0s7ok4uw	1538	7	domain	domain	NN
cord-001835-0s7ok4uw	1538	8	swapping	swapping	NN
cord-001835-0s7ok4uw	1538	9	,	,	,
cord-001835-0s7ok4uw	1538	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	1538	11	analyzed	analyze	VBD
cord-001835-0s7ok4uw	1538	12	the	the	DT
cord-001835-0s7ok4uw	1538	13	temperature	temperature	NN
cord-001835-0s7ok4uw	1538	14	and	and	CC
cord-001835-0s7ok4uw	1538	15	protein	protein	NN
cord-001835-0s7ok4uw	1538	16	concentration	concentration	NN
cord-001835-0s7ok4uw	1538	17	effects	effect	NNS
cord-001835-0s7ok4uw	1538	18	on	on	IN
cord-001835-0s7ok4uw	1538	19	the	the	DT
cord-001835-0s7ok4uw	1538	20	dimer	dimer	NN
cord-001835-0s7ok4uw	1538	21	dissociation	dissociation	NN
cord-001835-0s7ok4uw	1538	22	,	,	,
cord-001835-0s7ok4uw	1538	23	obtaining	obtain	VBG
cord-001835-0s7ok4uw	1538	24	the	the	DT
cord-001835-0s7ok4uw	1538	25	free	free	JJ
cord-001835-0s7ok4uw	1538	26	energy	energy	NN
cord-001835-0s7ok4uw	1538	27	change	change	NN
cord-001835-0s7ok4uw	1538	28	and	and	CC
cord-001835-0s7ok4uw	1538	29	enthalpy	enthalpy	NN
cord-001835-0s7ok4uw	1538	30	of	of	IN
cord-001835-0s7ok4uw	1538	31	the	the	DT
cord-001835-0s7ok4uw	1538	32	process	process	NN
cord-001835-0s7ok4uw	1538	33	by	by	IN
cord-001835-0s7ok4uw	1538	34	van't	van't	VBZ
cord-001835-0s7ok4uw	1538	35	Hoff	Hoff	NNP
cord-001835-0s7ok4uw	1538	36	analysis	analysis	NN
cord-001835-0s7ok4uw	1538	37	(	(	-LRB-
cord-001835-0s7ok4uw	1538	38	DH8	dh8	NN
cord-001835-0s7ok4uw	1538	39	of	of	IN
cord-001835-0s7ok4uw	1538	40	23.1	23.1	CD
cord-001835-0s7ok4uw	1538	41	kcal•mol-1	kcal•mol-1	NNP
cord-001835-0s7ok4uw	1538	42	,	,	,
cord-001835-0s7ok4uw	1538	43	DS8	DS8	NNP
cord-001835-0s7ok4uw	1538	44	of	of	IN
cord-001835-0s7ok4uw	1538	45	0.082	0.082	CD
cord-001835-0s7ok4uw	1538	46	kcal•mol-1•K-1	kcal•mol-1•k-1	CD
cord-001835-0s7ok4uw	1538	47	and	and	CC
cord-001835-0s7ok4uw	1538	48	DG8	dg8	NN
cord-001835-0s7ok4uw	1538	49	at	at	IN
cord-001835-0s7ok4uw	1538	50	258C	258c	CD
cord-001835-0s7ok4uw	1538	51	of	of	IN
cord-001835-0s7ok4uw	1538	52	20.95	20.95	CD
cord-001835-0s7ok4uw	1538	53	kcal•mol-1	kcal•mol-1	NNP
cord-001835-0s7ok4uw	1538	54	)	)	-RRB-
cord-001835-0s7ok4uw	1538	55	.	.	.
cord-001835-0s7ok4uw	1539	1	These	these	DT
cord-001835-0s7ok4uw	1539	2	results	result	NNS
cord-001835-0s7ok4uw	1539	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	1539	4	that	that	IN
cord-001835-0s7ok4uw	1539	5	the	the	DT
cord-001835-0s7ok4uw	1539	6	monomer	monomer	NN
cord-001835-0s7ok4uw	1539	7	-	-	HYPH
cord-001835-0s7ok4uw	1539	8	monomer	monomer	NN
cord-001835-0s7ok4uw	1539	9	association	association	NN
cord-001835-0s7ok4uw	1539	10	is	be	VBZ
cord-001835-0s7ok4uw	1539	11	an	an	DT
cord-001835-0s7ok4uw	1539	12	example	example	NN
cord-001835-0s7ok4uw	1539	13	of	of	IN
cord-001835-0s7ok4uw	1539	14	an	an	DT
cord-001835-0s7ok4uw	1539	15	enthalpy	enthalpy	NN
cord-001835-0s7ok4uw	1539	16	-	-	HYPH
cord-001835-0s7ok4uw	1539	17	driven	drive	VBN
cord-001835-0s7ok4uw	1539	18	process	process	NN
cord-001835-0s7ok4uw	1539	19	.	.	.
cord-001835-0s7ok4uw	1540	1	To	to	TO
cord-001835-0s7ok4uw	1540	2	understand	understand	VB
cord-001835-0s7ok4uw	1540	3	how	how	WRB
cord-001835-0s7ok4uw	1540	4	FoxP1	FoxP1	NNP
cord-001835-0s7ok4uw	1540	5	domains	domain	NNS
cord-001835-0s7ok4uw	1540	6	swap	swap	VBP
cord-001835-0s7ok4uw	1540	7	without	without	IN
cord-001835-0s7ok4uw	1540	8	protein	protein	NN
cord-001835-0s7ok4uw	1540	9	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1540	10	,	,	,
cord-001835-0s7ok4uw	1540	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	1540	12	performed	perform	VBD
cord-001835-0s7ok4uw	1540	13	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	1540	14	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1540	15	experiments	experiment	NNS
cord-001835-0s7ok4uw	1540	16	using	use	VBG
cord-001835-0s7ok4uw	1540	17	GndHCl	GndHCl	NNP
cord-001835-0s7ok4uw	1540	18	as	as	IN
cord-001835-0s7ok4uw	1540	19	denaturant	denaturant	JJ
cord-001835-0s7ok4uw	1540	20	,	,	,
cord-001835-0s7ok4uw	1540	21	showing	show	VBG
cord-001835-0s7ok4uw	1540	22	that	that	IN
cord-001835-0s7ok4uw	1540	23	the	the	DT
cord-001835-0s7ok4uw	1540	24	wild	wild	JJ
cord-001835-0s7ok4uw	1540	25	-	-	HYPH
cord-001835-0s7ok4uw	1540	26	type	type	NN
cord-001835-0s7ok4uw	1540	27	protein	protein	NN
cord-001835-0s7ok4uw	1540	28	has	have	VBZ
cord-001835-0s7ok4uw	1540	29	a	a	DT
cord-001835-0s7ok4uw	1540	30	low	low	JJ
cord-001835-0s7ok4uw	1540	31	stability	stability	NN
cord-001835-0s7ok4uw	1540	32	(	(	-LRB-
cord-001835-0s7ok4uw	1540	33	DGU	DGU	NNP
cord-001835-0s7ok4uw	1540	34	5	5	CD
cord-001835-0s7ok4uw	1540	35	6	6	CD
cord-001835-0s7ok4uw	1540	36	kcal•mol-1	kcal•mol-1	NNP
cord-001835-0s7ok4uw	1540	37	,	,	,
cord-001835-0s7ok4uw	1540	38	Cm	Cm	NNP
cord-001835-0s7ok4uw	1540	39	53.5	53.5	CD
cord-001835-0s7ok4uw	1540	40	M	m	NN
cord-001835-0s7ok4uw	1540	41	at	at	IN
cord-001835-0s7ok4uw	1540	42	258C	258c	CD
cord-001835-0s7ok4uw	1540	43	)	)	-RRB-
cord-001835-0s7ok4uw	1540	44	,	,	,
cord-001835-0s7ok4uw	1540	45	in	in	IN
cord-001835-0s7ok4uw	1540	46	contrast	contrast	NN
cord-001835-0s7ok4uw	1540	47	to	to	IN
cord-001835-0s7ok4uw	1540	48	other	other	JJ
cord-001835-0s7ok4uw	1540	49	domain	domain	NN
cord-001835-0s7ok4uw	1540	50	swapping	swap	VBG
cord-001835-0s7ok4uw	1540	51	proteins	protein	NNS
cord-001835-0s7ok4uw	1540	52	with	with	IN
cord-001835-0s7ok4uw	1540	53	high	high	JJ
cord-001835-0s7ok4uw	1540	54	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1540	55	barriers	barrier	NNS
cord-001835-0s7ok4uw	1540	56	.	.	.
cord-001835-0s7ok4uw	1541	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1541	2	further	further	RB
cord-001835-0s7ok4uw	1541	3	explore	explore	VBP
cord-001835-0s7ok4uw	1541	4	the	the	DT
cord-001835-0s7ok4uw	1541	5	domain	domain	NN
cord-001835-0s7ok4uw	1541	6	swapping	swapping	NN
cord-001835-0s7ok4uw	1541	7	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1541	8	of	of	IN
cord-001835-0s7ok4uw	1541	9	FoxP1	FoxP1	NNP
cord-001835-0s7ok4uw	1541	10	through	through	IN
cord-001835-0s7ok4uw	1541	11	biased	biased	JJ
cord-001835-0s7ok4uw	1541	12	targeted	targeted	JJ
cord-001835-0s7ok4uw	1541	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	1541	14	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1541	15	simulations	simulation	NNS
cord-001835-0s7ok4uw	1541	16	,	,	,
cord-001835-0s7ok4uw	1541	17	showing	show	VBG
cord-001835-0s7ok4uw	1541	18	that	that	IN
cord-001835-0s7ok4uw	1541	19	the	the	DT
cord-001835-0s7ok4uw	1541	20	exchange	exchange	NN
cord-001835-0s7ok4uw	1541	21	process	process	NN
cord-001835-0s7ok4uw	1541	22	can	can	MD
cord-001835-0s7ok4uw	1541	23	occur	occur	VB
cord-001835-0s7ok4uw	1541	24	by	by	IN
cord-001835-0s7ok4uw	1541	25	specific	specific	JJ
cord-001835-0s7ok4uw	1541	26	local	local	JJ
cord-001835-0s7ok4uw	1541	27	destabilization	destabilization	NN
cord-001835-0s7ok4uw	1541	28	and	and	CC
cord-001835-0s7ok4uw	1541	29	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1541	30	of	of	IN
cord-001835-0s7ok4uw	1541	31	the	the	DT
cord-001835-0s7ok4uw	1541	32	hinge	hinge	NN
cord-001835-0s7ok4uw	1541	33	region	region	NN
cord-001835-0s7ok4uw	1541	34	and	and	CC
cord-001835-0s7ok4uw	1541	35	helix	helix	NN
cord-001835-0s7ok4uw	1541	36	H3	H3	NNP
cord-001835-0s7ok4uw	1541	37	.	.	.
cord-001835-0s7ok4uw	1542	1	To	to	TO
cord-001835-0s7ok4uw	1542	2	further	further	RB
cord-001835-0s7ok4uw	1542	3	corroborate	corroborate	VB
cord-001835-0s7ok4uw	1542	4	that	that	IN
cord-001835-0s7ok4uw	1542	5	the	the	DT
cord-001835-0s7ok4uw	1542	6	low	low	JJ
cord-001835-0s7ok4uw	1542	7	stability	stability	NN
cord-001835-0s7ok4uw	1542	8	of	of	IN
cord-001835-0s7ok4uw	1542	9	wild	wild	JJ
cord-001835-0s7ok4uw	1542	10	-	-	HYPH
cord-001835-0s7ok4uw	1542	11	type	type	NN
cord-001835-0s7ok4uw	1542	12	FoxP1	FoxP1	NNP
cord-001835-0s7ok4uw	1542	13	facilitates	facilitate	VBZ
cord-001835-0s7ok4uw	1542	14	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1542	15	domain	domain	NN
cord-001835-0s7ok4uw	1542	16	swapping	swapping	NN
cord-001835-0s7ok4uw	1542	17	,	,	,
cord-001835-0s7ok4uw	1542	18	we	-PRON-	PRP
cord-001835-0s7ok4uw	1542	19	engineered	engineer	VBD
cord-001835-0s7ok4uw	1542	20	a	a	DT
cord-001835-0s7ok4uw	1542	21	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	1542	22	version	version	NN
cord-001835-0s7ok4uw	1542	23	of	of	IN
cord-001835-0s7ok4uw	1542	24	FoxP1	FoxP1	NNP
cord-001835-0s7ok4uw	1542	25	through	through	IN
cord-001835-0s7ok4uw	1542	26	a	a	DT
cord-001835-0s7ok4uw	1542	27	single	single	JJ
cord-001835-0s7ok4uw	1542	28	-	-	HYPH
cord-001835-0s7ok4uw	1542	29	point	point	NN
cord-001835-0s7ok4uw	1542	30	mutation	mutation	NN
cord-001835-0s7ok4uw	1542	31	in	in	IN
cord-001835-0s7ok4uw	1542	32	the	the	DT
cord-001835-0s7ok4uw	1542	33	hinge	hinge	NN
cord-001835-0s7ok4uw	1542	34	region	region	NN
cord-001835-0s7ok4uw	1542	35	,	,	,
cord-001835-0s7ok4uw	1542	36	which	which	WDT
cord-001835-0s7ok4uw	1542	37	has	have	VBZ
cord-001835-0s7ok4uw	1542	38	been	be	VBN
cord-001835-0s7ok4uw	1542	39	previously	previously	RB
cord-001835-0s7ok4uw	1542	40	described	describe	VBN
cord-001835-0s7ok4uw	1542	41	in	in	IN
cord-001835-0s7ok4uw	1542	42	the	the	DT
cord-001835-0s7ok4uw	1542	43	literature	literature	NN
cord-001835-0s7ok4uw	1542	44	,	,	,
cord-001835-0s7ok4uw	1542	45	and	and	CC
cord-001835-0s7ok4uw	1542	46	used	use	VBD
cord-001835-0s7ok4uw	1542	47	this	this	DT
cord-001835-0s7ok4uw	1542	48	protein	protein	NN
cord-001835-0s7ok4uw	1542	49	to	to	TO
cord-001835-0s7ok4uw	1542	50	visualize	visualize	VB
cord-001835-0s7ok4uw	1542	51	the	the	DT
cord-001835-0s7ok4uw	1542	52	effect	effect	NN
cord-001835-0s7ok4uw	1542	53	of	of	IN
cord-001835-0s7ok4uw	1542	54	monomer	monomer	NN
cord-001835-0s7ok4uw	1542	55	stability	stability	NN
cord-001835-0s7ok4uw	1542	56	in	in	IN
cord-001835-0s7ok4uw	1542	57	the	the	DT
cord-001835-0s7ok4uw	1542	58	dimer	dimer	NN
cord-001835-0s7ok4uw	1542	59	formation	formation	NN
cord-001835-0s7ok4uw	1542	60	.	.	.
cord-001835-0s7ok4uw	1543	1	Comparison	comparison	NN
cord-001835-0s7ok4uw	1543	2	of	of	IN
cord-001835-0s7ok4uw	1543	3	the	the	DT
cord-001835-0s7ok4uw	1543	4	folding	folding	NN
cord-001835-0s7ok4uw	1543	5	stability	stability	NN
cord-001835-0s7ok4uw	1543	6	of	of	IN
cord-001835-0s7ok4uw	1543	7	the	the	DT
cord-001835-0s7ok4uw	1543	8	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	1543	9	mutant	mutant	JJ
cord-001835-0s7ok4uw	1543	10	A39P	A39P	NNS
cord-001835-0s7ok4uw	1543	11	and	and	CC
cord-001835-0s7ok4uw	1543	12	wild	wild	JJ
cord-001835-0s7ok4uw	1543	13	-	-	HYPH
cord-001835-0s7ok4uw	1543	14	type	type	NN
cord-001835-0s7ok4uw	1543	15	FoxP1	FoxP1	NNP
cord-001835-0s7ok4uw	1543	16	shows	show	VBZ
cord-001835-0s7ok4uw	1543	17	that	that	IN
cord-001835-0s7ok4uw	1543	18	DDGU	DDGU	NNP
cord-001835-0s7ok4uw	1543	19	(	(	-LRB-
cord-001835-0s7ok4uw	1543	20	mutant	mutant	JJ
cord-001835-0s7ok4uw	1543	21	-	-	HYPH
cord-001835-0s7ok4uw	1543	22	wild	wild	JJ
cord-001835-0s7ok4uw	1543	23	-	-	HYPH
cord-001835-0s7ok4uw	1543	24	type	type	NN
cord-001835-0s7ok4uw	1543	25	)	)	-RRB-
cord-001835-0s7ok4uw	1543	26	is	be	VBZ
cord-001835-0s7ok4uw	1543	27	2.5	2.5	CD
cord-001835-0s7ok4uw	1543	28	kcal	kcal	NNP
cord-001835-0s7ok4uw	1543	29	/	/	SYM
cord-001835-0s7ok4uw	1543	30	mol	mol	NN
cord-001835-0s7ok4uw	1543	31	,	,	,
cord-001835-0s7ok4uw	1543	32	concluding	conclude	VBG
cord-001835-0s7ok4uw	1543	33	that	that	IN
cord-001835-0s7ok4uw	1543	34	the	the	DT
cord-001835-0s7ok4uw	1543	35	ability	ability	NN
cord-001835-0s7ok4uw	1543	36	of	of	IN
cord-001835-0s7ok4uw	1543	37	FoxP1	FoxP1	NNP
cord-001835-0s7ok4uw	1543	38	to	to	TO
cord-001835-0s7ok4uw	1543	39	domain	domain	NN
cord-001835-0s7ok4uw	1543	40	swap	swap	NN
cord-001835-0s7ok4uw	1543	41	rapidly	rapidly	RB
cord-001835-0s7ok4uw	1543	42	can	can	MD
cord-001835-0s7ok4uw	1543	43	be	be	VB
cord-001835-0s7ok4uw	1543	44	explained	explain	VBN
cord-001835-0s7ok4uw	1543	45	through	through	IN
cord-001835-0s7ok4uw	1543	46	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1543	47	low	low	JJ
cord-001835-0s7ok4uw	1543	48	monomer	monomer	NN
cord-001835-0s7ok4uw	1543	49	stability	stability	NN
cord-001835-0s7ok4uw	1543	50	and	and	CC
cord-001835-0s7ok4uw	1543	51	local	local	JJ
cord-001835-0s7ok4uw	1543	52	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1543	53	of	of	IN
cord-001835-0s7ok4uw	1543	54	the	the	DT
cord-001835-0s7ok4uw	1543	55	exchange	exchange	NN
cord-001835-0s7ok4uw	1543	56	region	region	NN
cord-001835-0s7ok4uw	1543	57	.	.	.
cord-001835-0s7ok4uw	1544	1	Funding	funding	NN
cord-001835-0s7ok4uw	1544	2	:	:	:
cord-001835-0s7ok4uw	1544	3	FONDECYT	FONDECYT	NNP
cord-001835-0s7ok4uw	1544	4	1130510	1130510	CD
cord-001835-0s7ok4uw	1544	5	and	and	CC
cord-001835-0s7ok4uw	1544	6	11140601	11140601	CD
cord-001835-0s7ok4uw	1544	7	.	.	.
cord-001835-0s7ok4uw	1545	1	Determining	determine	VBG
cord-001835-0s7ok4uw	1545	2	the	the	DT
cord-001835-0s7ok4uw	1545	3	coupled	coupled	JJ
cord-001835-0s7ok4uw	1545	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	1545	5	that	that	WDT
cord-001835-0s7ok4uw	1545	6	stabilize	stabilize	VBP
cord-001835-0s7ok4uw	1545	7	the	the	DT
cord-001835-0s7ok4uw	1545	8	structural	structural	JJ
cord-001835-0s7ok4uw	1545	9	framework	framework	NN
cord-001835-0s7ok4uw	1545	10	of	of	IN
cord-001835-0s7ok4uw	1545	11	the	the	DT
cord-001835-0s7ok4uw	1545	12	ß	ß	NN
cord-001835-0s7ok4uw	1545	13	-	-	HYPH
cord-001835-0s7ok4uw	1545	14	propeller	propeller	NN
cord-001835-0s7ok4uw	1545	15	fold	fold	NN
cord-001835-0s7ok4uw	1545	16	Loretta	Loretta	NNP
cord-001835-0s7ok4uw	1545	17	Au	Au	NNP
cord-001835-0s7ok4uw	1545	18	1	1	CD
cord-001835-0s7ok4uw	1545	19	,	,	,
cord-001835-0s7ok4uw	1545	20	David	David	NNP
cord-001835-0s7ok4uw	1545	21	Green	Green	NNP
cord-001835-0s7ok4uw	1545	22	2,3,4	2,3,4	CD
cord-001835-0s7ok4uw	1545	23	1	1	CD
cord-001835-0s7ok4uw	1545	24	Department	Department	NNP
cord-001835-0s7ok4uw	1545	25	of	of	IN
cord-001835-0s7ok4uw	1545	26	Statistics	Statistics	NNPS
cord-001835-0s7ok4uw	1545	27	,	,	,
cord-001835-0s7ok4uw	1545	28	The	the	DT
cord-001835-0s7ok4uw	1545	29	University	University	NNP
cord-001835-0s7ok4uw	1545	30	of	of	IN
cord-001835-0s7ok4uw	1545	31	Chicago	Chicago	NNP
cord-001835-0s7ok4uw	1545	32	,	,	,
cord-001835-0s7ok4uw	1545	33	2	2	CD
cord-001835-0s7ok4uw	1545	34	Department	Department	NNP
cord-001835-0s7ok4uw	1545	35	of	of	IN
cord-001835-0s7ok4uw	1545	36	Applied	Applied	NNP
cord-001835-0s7ok4uw	1545	37	Mathematics	Mathematics	NNP
cord-001835-0s7ok4uw	1545	38	and	and	CC
cord-001835-0s7ok4uw	1545	39	Statistics	Statistics	NNPS
cord-001835-0s7ok4uw	1545	40	,	,	,
cord-001835-0s7ok4uw	1545	41	Stony	Stony	NNP
cord-001835-0s7ok4uw	1545	42	Brook	Brook	NNP
cord-001835-0s7ok4uw	1545	43	University	University	NNP
cord-001835-0s7ok4uw	1545	44	,	,	,
cord-001835-0s7ok4uw	1545	45	3	3	CD
cord-001835-0s7ok4uw	1545	46	Graduate	Graduate	NNP
cord-001835-0s7ok4uw	1545	47	Program	Program	NNP
cord-001835-0s7ok4uw	1545	48	in	in	IN
cord-001835-0s7ok4uw	1545	49	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	1545	50	and	and	CC
cord-001835-0s7ok4uw	1545	51	Structural	Structural	NNP
cord-001835-0s7ok4uw	1545	52	Biology	Biology	NNP
cord-001835-0s7ok4uw	1545	53	,	,	,
cord-001835-0s7ok4uw	1545	54	Stony	Stony	NNP
cord-001835-0s7ok4uw	1545	55	Brook	Brook	NNP
cord-001835-0s7ok4uw	1545	56	University	University	NNP
cord-001835-0s7ok4uw	1545	57	,	,	,
cord-001835-0s7ok4uw	1545	58	4	4	CD
cord-001835-0s7ok4uw	1545	59	Laufer	Laufer	NNP
cord-001835-0s7ok4uw	1545	60	Center	Center	NNP
cord-001835-0s7ok4uw	1545	61	of	of	IN
cord-001835-0s7ok4uw	1545	62	Physical	Physical	NNP
cord-001835-0s7ok4uw	1545	63	and	and	CC
cord-001835-0s7ok4uw	1545	64	Quantitative	Quantitative	NNP
cord-001835-0s7ok4uw	1545	65	Biology	Biology	NNP
cord-001835-0s7ok4uw	1545	66	,	,	,
cord-001835-0s7ok4uw	1545	67	Stony	Stony	NNP
cord-001835-0s7ok4uw	1545	68	Brook	Brook	NNP
cord-001835-0s7ok4uw	1545	69	University	University	NNP
cord-001835-0s7ok4uw	1545	70	b	b	NN
cord-001835-0s7ok4uw	1545	71	-	-	HYPH
cord-001835-0s7ok4uw	1545	72	propeller	propeller	NN
cord-001835-0s7ok4uw	1545	73	proteins	protein	NNS
cord-001835-0s7ok4uw	1545	74	are	be	VBP
cord-001835-0s7ok4uw	1545	75	a	a	DT
cord-001835-0s7ok4uw	1545	76	highly	highly	RB
cord-001835-0s7ok4uw	1545	77	evolved	evolve	VBN
cord-001835-0s7ok4uw	1545	78	family	family	NN
cord-001835-0s7ok4uw	1545	79	of	of	IN
cord-001835-0s7ok4uw	1545	80	repeat	repeat	NN
cord-001835-0s7ok4uw	1545	81	proteins	protein	NNS
cord-001835-0s7ok4uw	1545	82	that	that	WDT
cord-001835-0s7ok4uw	1545	83	are	be	VBP
cord-001835-0s7ok4uw	1545	84	involved	involve	VBN
cord-001835-0s7ok4uw	1545	85	in	in	IN
cord-001835-0s7ok4uw	1545	86	several	several	JJ
cord-001835-0s7ok4uw	1545	87	biological	biological	JJ
cord-001835-0s7ok4uw	1545	88	pathways	pathway	NNS
cord-001835-0s7ok4uw	1545	89	,	,	,
cord-001835-0s7ok4uw	1545	90	such	such	JJ
cord-001835-0s7ok4uw	1545	91	as	as	IN
cord-001835-0s7ok4uw	1545	92	signal	signal	NN
cord-001835-0s7ok4uw	1545	93	transduction	transduction	NN
cord-001835-0s7ok4uw	1545	94	,	,	,
cord-001835-0s7ok4uw	1545	95	cell	cell	NN
cord-001835-0s7ok4uw	1545	96	-	-	HYPH
cord-001835-0s7ok4uw	1545	97	cycle	cycle	NN
cord-001835-0s7ok4uw	1545	98	modulation	modulation	NN
cord-001835-0s7ok4uw	1545	99	and	and	CC
cord-001835-0s7ok4uw	1545	100	transcription	transcription	NN
cord-001835-0s7ok4uw	1545	101	regulation	regulation	NN
cord-001835-0s7ok4uw	1545	102	,	,	,
cord-001835-0s7ok4uw	1545	103	through	through	IN
cord-001835-0s7ok4uw	1545	104	interactions	interaction	NNS
cord-001835-0s7ok4uw	1545	105	with	with	IN
cord-001835-0s7ok4uw	1545	106	diverse	diverse	JJ
cord-001835-0s7ok4uw	1545	107	binding	bind	VBG
cord-001835-0s7ok4uw	1545	108	partners	partner	NNS
cord-001835-0s7ok4uw	1545	109	,	,	,
cord-001835-0s7ok4uw	1545	110	despite	despite	IN
cord-001835-0s7ok4uw	1545	111	having	have	VBG
cord-001835-0s7ok4uw	1545	112	a	a	DT
cord-001835-0s7ok4uw	1545	113	similar	similar	JJ
cord-001835-0s7ok4uw	1545	114	fold	fold	NN
cord-001835-0s7ok4uw	1545	115	.	.	.
cord-001835-0s7ok4uw	1546	1	As	as	IN
cord-001835-0s7ok4uw	1546	2	for	for	IN
cord-001835-0s7ok4uw	1546	3	all	all	DT
cord-001835-0s7ok4uw	1546	4	repeat	repeat	VBP
cord-001835-0s7ok4uw	1546	5	protein	protein	NN
cord-001835-0s7ok4uw	1546	6	families	family	NNS
cord-001835-0s7ok4uw	1546	7	,	,	,
cord-001835-0s7ok4uw	1546	8	there	there	EX
cord-001835-0s7ok4uw	1546	9	is	be	VBZ
cord-001835-0s7ok4uw	1546	10	a	a	DT
cord-001835-0s7ok4uw	1546	11	consistent	consistent	JJ
cord-001835-0s7ok4uw	1546	12	pattern	pattern	NN
cord-001835-0s7ok4uw	1546	13	in	in	IN
cord-001835-0s7ok4uw	1546	14	secondary	secondary	JJ
cord-001835-0s7ok4uw	1546	15	structure	structure	NN
cord-001835-0s7ok4uw	1546	16	for	for	IN
cord-001835-0s7ok4uw	1546	17	each	each	DT
cord-001835-0s7ok4uw	1546	18	repetitive	repetitive	JJ
cord-001835-0s7ok4uw	1546	19	region	region	NN
cord-001835-0s7ok4uw	1546	20	,	,	,
cord-001835-0s7ok4uw	1546	21	in	in	IN
cord-001835-0s7ok4uw	1546	22	addition	addition	NN
cord-001835-0s7ok4uw	1546	23	to	to	IN
cord-001835-0s7ok4uw	1546	24	the	the	DT
cord-001835-0s7ok4uw	1546	25	entire	entire	JJ
cord-001835-0s7ok4uw	1546	26	family	family	NN
cord-001835-0s7ok4uw	1546	27	.	.	.
cord-001835-0s7ok4uw	1547	1	Typically	typically	RB
cord-001835-0s7ok4uw	1547	2	,	,	,
cord-001835-0s7ok4uw	1547	3	four	four	CD
cord-001835-0s7ok4uw	1547	4	to	to	TO
cord-001835-0s7ok4uw	1547	5	ten	ten	CD
cord-001835-0s7ok4uw	1547	6	propeller	propeller	NN
cord-001835-0s7ok4uw	1547	7	blades	blade	NNS
cord-001835-0s7ok4uw	1547	8	(	(	-LRB-
cord-001835-0s7ok4uw	1547	9	each	each	DT
cord-001835-0s7ok4uw	1547	10	containing	contain	VBG
cord-001835-0s7ok4uw	1547	11	four	four	CD
cord-001835-0s7ok4uw	1547	12	anti	anti	JJ
cord-001835-0s7ok4uw	1547	13	-	-	JJ
cord-001835-0s7ok4uw	1547	14	parallel	parallel	JJ
cord-001835-0s7ok4uw	1547	15	b	b	NN
cord-001835-0s7ok4uw	1547	16	-	-	HYPH
cord-001835-0s7ok4uw	1547	17	sheets	sheet	NNS
cord-001835-0s7ok4uw	1547	18	)	)	-RRB-
cord-001835-0s7ok4uw	1547	19	are	be	VBP
cord-001835-0s7ok4uw	1547	20	arranged	arrange	VBN
cord-001835-0s7ok4uw	1547	21	in	in	IN
cord-001835-0s7ok4uw	1547	22	a	a	DT
cord-001835-0s7ok4uw	1547	23	toroidal	toroidal	JJ
cord-001835-0s7ok4uw	1547	24	shape	shape	NN
cord-001835-0s7ok4uw	1547	25	,	,	,
cord-001835-0s7ok4uw	1547	26	thus	thus	RB
cord-001835-0s7ok4uw	1547	27	providing	provide	VBG
cord-001835-0s7ok4uw	1547	28	a	a	DT
cord-001835-0s7ok4uw	1547	29	large	large	JJ
cord-001835-0s7ok4uw	1547	30	binding	binding	NN
cord-001835-0s7ok4uw	1547	31	surface	surface	NN
cord-001835-0s7ok4uw	1547	32	for	for	IN
cord-001835-0s7ok4uw	1547	33	ligands	ligand	NNS
cord-001835-0s7ok4uw	1547	34	or	or	CC
cord-001835-0s7ok4uw	1547	35	other	other	JJ
cord-001835-0s7ok4uw	1547	36	proteins	protein	NNS
cord-001835-0s7ok4uw	1547	37	.	.	.
cord-001835-0s7ok4uw	1548	1	About	about	RB
cord-001835-0s7ok4uw	1548	2	1	1	CD
cord-001835-0s7ok4uw	1548	3	%	%	NN
cord-001835-0s7ok4uw	1548	4	of	of	IN
cord-001835-0s7ok4uw	1548	5	known	know	VBN
cord-001835-0s7ok4uw	1548	6	proteins	protein	NNS
cord-001835-0s7ok4uw	1548	7	adopt	adopt	VBP
cord-001835-0s7ok4uw	1548	8	this	this	DT
cord-001835-0s7ok4uw	1548	9	distinctive	distinctive	JJ
cord-001835-0s7ok4uw	1548	10	fold	fold	NN
cord-001835-0s7ok4uw	1548	11	,	,	,
cord-001835-0s7ok4uw	1548	12	and	and	CC
cord-001835-0s7ok4uw	1548	13	although	although	IN
cord-001835-0s7ok4uw	1548	14	the	the	DT
cord-001835-0s7ok4uw	1548	15	requirements	requirement	NNS
cord-001835-0s7ok4uw	1548	16	for	for	IN
cord-001835-0s7ok4uw	1548	17	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	1548	18	structure	structure	NN
cord-001835-0s7ok4uw	1548	19	and	and	CC
cord-001835-0s7ok4uw	1548	20	protein	protein	NN
cord-001835-0s7ok4uw	1548	21	function	function	NN
cord-001835-0s7ok4uw	1548	22	are	be	VBP
cord-001835-0s7ok4uw	1548	23	fundamentally	fundamentally	RB
cord-001835-0s7ok4uw	1548	24	encoded	encode	VBN
cord-001835-0s7ok4uw	1548	25	in	in	IN
cord-001835-0s7ok4uw	1548	26	primary	primary	JJ
cord-001835-0s7ok4uw	1548	27	structure	structure	NN
cord-001835-0s7ok4uw	1548	28	,	,	,
cord-001835-0s7ok4uw	1548	29	this	this	DT
cord-001835-0s7ok4uw	1548	30	relationship	relationship	NN
cord-001835-0s7ok4uw	1548	31	is	be	VBZ
cord-001835-0s7ok4uw	1548	32	not	not	RB
cord-001835-0s7ok4uw	1548	33	fully	fully	RB
cord-001835-0s7ok4uw	1548	34	understood	understand	VBN
cord-001835-0s7ok4uw	1548	35	,	,	,
cord-001835-0s7ok4uw	1548	36	and	and	CC
cord-001835-0s7ok4uw	1548	37	addressing	address	VBG
cord-001835-0s7ok4uw	1548	38	it	-PRON-	PRP
cord-001835-0s7ok4uw	1548	39	could	could	MD
cord-001835-0s7ok4uw	1548	40	provide	provide	VB
cord-001835-0s7ok4uw	1548	41	insight	insight	NN
cord-001835-0s7ok4uw	1548	42	on	on	IN
cord-001835-0s7ok4uw	1548	43	why	why	WRB
cord-001835-0s7ok4uw	1548	44	the	the	DT
cord-001835-0s7ok4uw	1548	45	b	b	NN
cord-001835-0s7ok4uw	1548	46	-	-	HYPH
cord-001835-0s7ok4uw	1548	47	propeller	propeller	NN
cord-001835-0s7ok4uw	1548	48	fold	fold	NN
cord-001835-0s7ok4uw	1548	49	is	be	VBZ
cord-001835-0s7ok4uw	1548	50	common	common	JJ
cord-001835-0s7ok4uw	1548	51	.	.	.
cord-001835-0s7ok4uw	1549	1	Many	many	JJ
cord-001835-0s7ok4uw	1549	2	techniques	technique	NNS
cord-001835-0s7ok4uw	1549	3	in	in	IN
cord-001835-0s7ok4uw	1549	4	comparative	comparative	JJ
cord-001835-0s7ok4uw	1549	5	sequence	sequence	NN
cord-001835-0s7ok4uw	1549	6	analysis	analysis	NN
cord-001835-0s7ok4uw	1549	7	can	can	MD
cord-001835-0s7ok4uw	1549	8	successfully	successfully	RB
cord-001835-0s7ok4uw	1549	9	identify	identify	VB
cord-001835-0s7ok4uw	1549	10	amino	amino	NN
cord-001835-0s7ok4uw	1549	11	-	-	HYPH
cord-001835-0s7ok4uw	1549	12	acid	acid	NN
cord-001835-0s7ok4uw	1549	13	conservation	conservation	NN
cord-001835-0s7ok4uw	1549	14	between	between	IN
cord-001835-0s7ok4uw	1549	15	closely	closely	RB
cord-001835-0s7ok4uw	1549	16	related	related	JJ
cord-001835-0s7ok4uw	1549	17	proteins	protein	NNS
cord-001835-0s7ok4uw	1549	18	,	,	,
cord-001835-0s7ok4uw	1549	19	but	but	CC
cord-001835-0s7ok4uw	1549	20	molecular	molecular	JJ
cord-001835-0s7ok4uw	1549	21	interactions	interaction	NNS
cord-001835-0s7ok4uw	1549	22	between	between	IN
cord-001835-0s7ok4uw	1549	23	amino	amino	NN
cord-001835-0s7ok4uw	1549	24	acids	acid	NNS
cord-001835-0s7ok4uw	1549	25	are	be	VBP
cord-001835-0s7ok4uw	1549	26	often	often	RB
cord-001835-0s7ok4uw	1549	27	neglected	neglect	VBN
cord-001835-0s7ok4uw	1549	28	,	,	,
cord-001835-0s7ok4uw	1549	29	and	and	CC
cord-001835-0s7ok4uw	1549	30	further	further	JJ
cord-001835-0s7ok4uw	1549	31	experimentation	experimentation	NN
cord-001835-0s7ok4uw	1549	32	is	be	VBZ
cord-001835-0s7ok4uw	1549	33	still	still	RB
cord-001835-0s7ok4uw	1549	34	needed	need	VBN
cord-001835-0s7ok4uw	1549	35	to	to	TO
cord-001835-0s7ok4uw	1549	36	determine	determine	VB
cord-001835-0s7ok4uw	1549	37	the	the	DT
cord-001835-0s7ok4uw	1549	38	reasons	reason	NNS
cord-001835-0s7ok4uw	1549	39	underlying	underlie	VBG
cord-001835-0s7ok4uw	1549	40	conservation	conservation	NN
cord-001835-0s7ok4uw	1549	41	.	.	.
cord-001835-0s7ok4uw	1550	1	To	to	TO
cord-001835-0s7ok4uw	1550	2	explore	explore	VB
cord-001835-0s7ok4uw	1550	3	how	how	WRB
cord-001835-0s7ok4uw	1550	4	primary	primary	JJ
cord-001835-0s7ok4uw	1550	5	structure	structure	NN
cord-001835-0s7ok4uw	1550	6	can	can	MD
cord-001835-0s7ok4uw	1550	7	dictate	dictate	VB
cord-001835-0s7ok4uw	1550	8	fold	fold	VB
cord-001835-0s7ok4uw	1550	9	and	and	CC
cord-001835-0s7ok4uw	1550	10	function	function	VB
cord-001835-0s7ok4uw	1550	11	,	,	,
cord-001835-0s7ok4uw	1550	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	1550	13	devised	devise	VBD
cord-001835-0s7ok4uw	1550	14	a	a	DT
cord-001835-0s7ok4uw	1550	15	computational	computational	JJ
cord-001835-0s7ok4uw	1550	16	approach	approach	NN
cord-001835-0s7ok4uw	1550	17	to	to	TO
cord-001835-0s7ok4uw	1550	18	perform	perform	VB
cord-001835-0s7ok4uw	1550	19	large	large	JJ
cord-001835-0s7ok4uw	1550	20	-	-	HYPH
cord-001835-0s7ok4uw	1550	21	scale	scale	NN
cord-001835-0s7ok4uw	1550	22	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	1550	23	,	,	,
cord-001835-0s7ok4uw	1550	24	by	by	IN
cord-001835-0s7ok4uw	1550	25	adapting	adapt	VBG
cord-001835-0s7ok4uw	1550	26	the	the	DT
cord-001835-0s7ok4uw	1550	27	dead	dead	JJ
cord-001835-0s7ok4uw	1550	28	-	-	HYPH
cord-001835-0s7ok4uw	1550	29	end	end	NN
cord-001835-0s7ok4uw	1550	30	elimination	elimination	NN
cord-001835-0s7ok4uw	1550	31	and	and	CC
cord-001835-0s7ok4uw	1550	32	A	a	DT
cord-001835-0s7ok4uw	1550	33	*	*	NFP
cord-001835-0s7ok4uw	1550	34	search	search	NN
cord-001835-0s7ok4uw	1550	35	algorithms	algorithm	NNS
cord-001835-0s7ok4uw	1550	36	(	(	-LRB-
cord-001835-0s7ok4uw	1550	37	DEE	DEE	NNP
cord-001835-0s7ok4uw	1550	38	/	/	SYM
cord-001835-0s7ok4uw	1550	39	A	A	NNP
cord-001835-0s7ok4uw	1550	40	*	*	NFP
cord-001835-0s7ok4uw	1550	41	)	)	-RRB-
cord-001835-0s7ok4uw	1550	42	,	,	,
cord-001835-0s7ok4uw	1550	43	and	and	CC
cord-001835-0s7ok4uw	1550	44	also	also	RB
cord-001835-0s7ok4uw	1550	45	leveraged	leverage	VBD
cord-001835-0s7ok4uw	1550	46	the	the	DT
cord-001835-0s7ok4uw	1550	47	structural	structural	JJ
cord-001835-0s7ok4uw	1550	48	conservation	conservation	NN
cord-001835-0s7ok4uw	1550	49	of	of	IN
cord-001835-0s7ok4uw	1550	50	each	each	DT
cord-001835-0s7ok4uw	1550	51	repeating	repeat	VBG
cord-001835-0s7ok4uw	1550	52	region	region	NN
cord-001835-0s7ok4uw	1550	53	to	to	TO
cord-001835-0s7ok4uw	1550	54	understand	understand	VB
cord-001835-0s7ok4uw	1550	55	how	how	WRB
cord-001835-0s7ok4uw	1550	56	sequence	sequence	NN
cord-001835-0s7ok4uw	1550	57	variation	variation	NN
cord-001835-0s7ok4uw	1550	58	influences	influence	VBZ
cord-001835-0s7ok4uw	1550	59	protein	protein	NN
cord-001835-0s7ok4uw	1550	60	fitness	fitness	NN
cord-001835-0s7ok4uw	1550	61	,	,	,
cord-001835-0s7ok4uw	1550	62	defined	define	VBN
cord-001835-0s7ok4uw	1550	63	here	here	RB
cord-001835-0s7ok4uw	1550	64	as	as	IN
cord-001835-0s7ok4uw	1550	65	a	a	DT
cord-001835-0s7ok4uw	1550	66	combination	combination	NN
cord-001835-0s7ok4uw	1550	67	of	of	IN
cord-001835-0s7ok4uw	1550	68	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	1550	69	and	and	CC
cord-001835-0s7ok4uw	1550	70	binding	bind	VBG
cord-001835-0s7ok4uw	1550	71	interactions	interaction	NNS
cord-001835-0s7ok4uw	1550	72	.	.	.
cord-001835-0s7ok4uw	1551	1	DEE	DEE	NNP
cord-001835-0s7ok4uw	1551	2	/	/	SYM
cord-001835-0s7ok4uw	1551	3	A	A	NNP
cord-001835-0s7ok4uw	1551	4	*	*	NFP
cord-001835-0s7ok4uw	1551	5	can	can	MD
cord-001835-0s7ok4uw	1551	6	evaluate	evaluate	VB
cord-001835-0s7ok4uw	1551	7	low	low	JJ
cord-001835-0s7ok4uw	1551	8	-	-	HYPH
cord-001835-0s7ok4uw	1551	9	energy	energy	NN
cord-001835-0s7ok4uw	1551	10	protein	protein	NN
cord-001835-0s7ok4uw	1551	11	sequences	sequence	NNS
cord-001835-0s7ok4uw	1551	12	and	and	CC
cord-001835-0s7ok4uw	1551	13	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1551	14	corresponding	corresponding	JJ
cord-001835-0s7ok4uw	1551	15	three	three	CD
cord-001835-0s7ok4uw	1551	16	-	-	HYPH
cord-001835-0s7ok4uw	1551	17	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	1551	18	structures	structure	NNS
cord-001835-0s7ok4uw	1551	19	,	,	,
cord-001835-0s7ok4uw	1551	20	and	and	CC
cord-001835-0s7ok4uw	1551	21	we	-PRON-	PRP
cord-001835-0s7ok4uw	1551	22	used	use	VBD
cord-001835-0s7ok4uw	1551	23	the	the	DT
cord-001835-0s7ok4uw	1551	24	bsubunit	bsubunit	NNS
cord-001835-0s7ok4uw	1551	25	of	of	IN
cord-001835-0s7ok4uw	1551	26	a	a	DT
cord-001835-0s7ok4uw	1551	27	G	g	NN
cord-001835-0s7ok4uw	1551	28	-	-	HYPH
cord-001835-0s7ok4uw	1551	29	protein	protein	NN
cord-001835-0s7ok4uw	1551	30	heterotrimer	heterotrimer	NN
cord-001835-0s7ok4uw	1551	31	(	(	-LRB-
cord-001835-0s7ok4uw	1551	32	PDB	PDB	NNP
cord-001835-0s7ok4uw	1551	33	:	:	:
cord-001835-0s7ok4uw	1551	34	1GP2	1gp2	CD
cord-001835-0s7ok4uw	1551	35	,	,	,
cord-001835-0s7ok4uw	1551	36	Gia1b1g2	Gia1b1g2	NNP
cord-001835-0s7ok4uw	1551	37	)	)	-RRB-
cord-001835-0s7ok4uw	1551	38	as	as	IN
cord-001835-0s7ok4uw	1551	39	a	a	DT
cord-001835-0s7ok4uw	1551	40	model	model	NN
cord-001835-0s7ok4uw	1551	41	system	system	NN
cord-001835-0s7ok4uw	1551	42	to	to	TO
cord-001835-0s7ok4uw	1551	43	demonstrate	demonstrate	VB
cord-001835-0s7ok4uw	1551	44	:	:	:
cord-001835-0s7ok4uw	1551	45	(	(	-LRB-
cord-001835-0s7ok4uw	1551	46	1	1	LS
cord-001835-0s7ok4uw	1551	47	)	)	-RRB-
cord-001835-0s7ok4uw	1551	48	how	how	WRB
cord-001835-0s7ok4uw	1551	49	the	the	DT
cord-001835-0s7ok4uw	1551	50	multiple	multiple	JJ
cord-001835-0s7ok4uw	1551	51	roles	role	NNS
cord-001835-0s7ok4uw	1551	52	of	of	IN
cord-001835-0s7ok4uw	1551	53	individual	individual	JJ
cord-001835-0s7ok4uw	1551	54	amino	amino	NN
cord-001835-0s7ok4uw	1551	55	acids	acid	NNS
cord-001835-0s7ok4uw	1551	56	in	in	IN
cord-001835-0s7ok4uw	1551	57	protein	protein	NN
cord-001835-0s7ok4uw	1551	58	fitness	fitness	NN
cord-001835-0s7ok4uw	1551	59	can	can	MD
cord-001835-0s7ok4uw	1551	60	be	be	VB
cord-001835-0s7ok4uw	1551	61	deconvolved	deconvolve	VBN
cord-001835-0s7ok4uw	1551	62	,	,	,
cord-001835-0s7ok4uw	1551	63	and	and	CC
cord-001835-0s7ok4uw	1551	64	(	(	-LRB-
cord-001835-0s7ok4uw	1551	65	2	2	LS
cord-001835-0s7ok4uw	1551	66	)	)	-RRB-
cord-001835-0s7ok4uw	1551	67	how	how	WRB
cord-001835-0s7ok4uw	1551	68	epistatic	epistatic	JJ
cord-001835-0s7ok4uw	1551	69	interactions	interaction	NNS
cord-001835-0s7ok4uw	1551	70	between	between	IN
cord-001835-0s7ok4uw	1551	71	them	-PRON-	PRP
cord-001835-0s7ok4uw	1551	72	can	can	MD
cord-001835-0s7ok4uw	1551	73	contribute	contribute	VB
cord-001835-0s7ok4uw	1551	74	to	to	IN
cord-001835-0s7ok4uw	1551	75	structural	structural	JJ
cord-001835-0s7ok4uw	1551	76	stability	stability	NN
cord-001835-0s7ok4uw	1551	77	.	.	.
cord-001835-0s7ok4uw	1552	1	In	in	IN
cord-001835-0s7ok4uw	1552	2	doing	do	VBG
cord-001835-0s7ok4uw	1552	3	so	so	RB
cord-001835-0s7ok4uw	1552	4	,	,	,
cord-001835-0s7ok4uw	1552	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1552	6	were	be	VBD
cord-001835-0s7ok4uw	1552	7	able	able	JJ
cord-001835-0s7ok4uw	1552	8	to	to	TO
cord-001835-0s7ok4uw	1552	9	identify	identify	VB
cord-001835-0s7ok4uw	1552	10	important	important	JJ
cord-001835-0s7ok4uw	1552	11	patterns	pattern	NNS
cord-001835-0s7ok4uw	1552	12	in	in	IN
cord-001835-0s7ok4uw	1552	13	sequence	sequence	NN
cord-001835-0s7ok4uw	1552	14	complementarity	complementarity	NN
cord-001835-0s7ok4uw	1552	15	between	between	IN
cord-001835-0s7ok4uw	1552	16	repeating	repeat	VBG
cord-001835-0s7ok4uw	1552	17	regions	region	NNS
cord-001835-0s7ok4uw	1552	18	that	that	WDT
cord-001835-0s7ok4uw	1552	19	can	can	MD
cord-001835-0s7ok4uw	1552	20	not	not	RB
cord-001835-0s7ok4uw	1552	21	be	be	VB
cord-001835-0s7ok4uw	1552	22	found	find	VBN
cord-001835-0s7ok4uw	1552	23	using	use	VBG
cord-001835-0s7ok4uw	1552	24	sequencebased	sequencebase	VBN
cord-001835-0s7ok4uw	1552	25	methods	method	NNS
cord-001835-0s7ok4uw	1552	26	alone	alone	RB
cord-001835-0s7ok4uw	1552	27	.	.	.
cord-001835-0s7ok4uw	1553	1	These	these	DT
cord-001835-0s7ok4uw	1553	2	results	result	NNS
cord-001835-0s7ok4uw	1553	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	1553	4	that	that	IN
cord-001835-0s7ok4uw	1553	5	computational	computational	JJ
cord-001835-0s7ok4uw	1553	6	approaches	approach	NNS
cord-001835-0s7ok4uw	1553	7	can	can	MD
cord-001835-0s7ok4uw	1553	8	be	be	VB
cord-001835-0s7ok4uw	1553	9	used	use	VBN
cord-001835-0s7ok4uw	1553	10	to	to	TO
cord-001835-0s7ok4uw	1553	11	determine	determine	VB
cord-001835-0s7ok4uw	1553	12	important	important	JJ
cord-001835-0s7ok4uw	1553	13	protein	protein	NN
cord-001835-0s7ok4uw	1553	14	interactions	interaction	NNS
cord-001835-0s7ok4uw	1553	15	,	,	,
cord-001835-0s7ok4uw	1553	16	and	and	CC
cord-001835-0s7ok4uw	1553	17	help	help	VB
cord-001835-0s7ok4uw	1553	18	elucidate	elucidate	VB
cord-001835-0s7ok4uw	1553	19	the	the	DT
cord-001835-0s7ok4uw	1553	20	prevalence	prevalence	NN
cord-001835-0s7ok4uw	1553	21	of	of	IN
cord-001835-0s7ok4uw	1553	22	b	b	NN
cord-001835-0s7ok4uw	1553	23	-	-	HYPH
cord-001835-0s7ok4uw	1553	24	propeller	propeller	NN
cord-001835-0s7ok4uw	1553	25	proteins	protein	NNS
cord-001835-0s7ok4uw	1553	26	in	in	IN
cord-001835-0s7ok4uw	1553	27	biology	biology	NN
cord-001835-0s7ok4uw	1553	28	.	.	.
cord-001835-0s7ok4uw	1554	1	Temperature	temperature	NN
cord-001835-0s7ok4uw	1554	2	induced	induce	VBN
cord-001835-0s7ok4uw	1554	3	conformational	conformational	JJ
cord-001835-0s7ok4uw	1554	4	changes	change	NNS
cord-001835-0s7ok4uw	1554	5	of	of	IN
cord-001835-0s7ok4uw	1554	6	the	the	DT
cord-001835-0s7ok4uw	1554	7	villin	villin	NNP
cord-001835-0s7ok4uw	1554	8	headpiece	headpiece	NN
cord-001835-0s7ok4uw	1554	9	miniprotein	miniprotein	NNP
cord-001835-0s7ok4uw	1554	10	Stanislaw	Stanislaw	NNP
cord-001835-0s7ok4uw	1554	11	Oldziej	Oldziej	NNP
cord-001835-0s7ok4uw	1554	12	1	1	CD
cord-001835-0s7ok4uw	1554	13	,	,	,
cord-001835-0s7ok4uw	1554	14	Wioletta	Wioletta	NNP
cord-001835-0s7ok4uw	1554	15	_	_	NNP
cord-001835-0s7ok4uw	1554	16	Zmudzi	Zmudzi	NNP
cord-001835-0s7ok4uw	1554	17	nska	nska	NNP
cord-001835-0s7ok4uw	1554	18	1	1	CD
cord-001835-0s7ok4uw	1554	19	,	,	,
cord-001835-0s7ok4uw	1554	20	Anna	Anna	NNP
cord-001835-0s7ok4uw	1554	21	Hałabis	Hałabis	NNP
cord-001835-0s7ok4uw	1554	22	1	1	CD
cord-001835-0s7ok4uw	1554	23	1	1	CD
cord-001835-0s7ok4uw	1555	1	The	the	DT
cord-001835-0s7ok4uw	1555	2	C	c	NN
cord-001835-0s7ok4uw	1555	3	-	-	HYPH
cord-001835-0s7ok4uw	1555	4	terminal	terminal	NN
cord-001835-0s7ok4uw	1555	5	subdomain	subdomain	NN
cord-001835-0s7ok4uw	1555	6	of	of	IN
cord-001835-0s7ok4uw	1555	7	the	the	DT
cord-001835-0s7ok4uw	1555	8	actin	actin	NN
cord-001835-0s7ok4uw	1555	9	-	-	HYPH
cord-001835-0s7ok4uw	1555	10	binding	bind	VBG
cord-001835-0s7ok4uw	1555	11	protein	protein	NN
cord-001835-0s7ok4uw	1555	12	villin	villin	NN
cord-001835-0s7ok4uw	1555	13	called	call	VBN
cord-001835-0s7ok4uw	1555	14	HP35	HP35	NNP
cord-001835-0s7ok4uw	1555	15	(	(	-LRB-
cord-001835-0s7ok4uw	1555	16	villin	villin	NNP
cord-001835-0s7ok4uw	1555	17	headpiece	headpiece	NN
cord-001835-0s7ok4uw	1555	18	)	)	-RRB-
cord-001835-0s7ok4uw	1555	19	has	have	VBZ
cord-001835-0s7ok4uw	1555	20	been	be	VBN
cord-001835-0s7ok4uw	1555	21	used	use	VBN
cord-001835-0s7ok4uw	1555	22	as	as	IN
cord-001835-0s7ok4uw	1555	23	a	a	DT
cord-001835-0s7ok4uw	1555	24	model	model	NN
cord-001835-0s7ok4uw	1555	25	protein	protein	NN
cord-001835-0s7ok4uw	1555	26	in	in	IN
cord-001835-0s7ok4uw	1555	27	a	a	DT
cord-001835-0s7ok4uw	1555	28	number	number	NN
cord-001835-0s7ok4uw	1555	29	of	of	IN
cord-001835-0s7ok4uw	1555	30	studies	study	NNS
cord-001835-0s7ok4uw	1555	31	of	of	IN
cord-001835-0s7ok4uw	1555	32	protein	protein	NN
cord-001835-0s7ok4uw	1555	33	folding	folding	NN
cord-001835-0s7ok4uw	1555	34	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	1555	35	and	and	CC
cord-001835-0s7ok4uw	1555	36	protein	protein	NN
cord-001835-0s7ok4uw	1555	37	folding	folding	NN
cord-001835-0s7ok4uw	1555	38	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1555	39	[	[	-LRB-
cord-001835-0s7ok4uw	1555	40	1	1	CD
cord-001835-0s7ok4uw	1555	41	,	,	,
cord-001835-0s7ok4uw	1555	42	2	2	CD
cord-001835-0s7ok4uw	1555	43	]	]	-RRB-
cord-001835-0s7ok4uw	1555	44	.	.	.
cord-001835-0s7ok4uw	1556	1	The	the	DT
cord-001835-0s7ok4uw	1556	2	HP35	HP35	NNP
cord-001835-0s7ok4uw	1556	3	is	be	VBZ
cord-001835-0s7ok4uw	1556	4	a	a	DT
cord-001835-0s7ok4uw	1556	5	35	35	CD
cord-001835-0s7ok4uw	1556	6	residue	residue	NN
cord-001835-0s7ok4uw	1556	7	miniprotein	miniprotein	NNP
cord-001835-0s7ok4uw	1556	8	with	with	IN
cord-001835-0s7ok4uw	1556	9	an	an	DT
cord-001835-0s7ok4uw	1556	10	alpha	alpha	JJ
cord-001835-0s7ok4uw	1556	11	-	-	HYPH
cord-001835-0s7ok4uw	1556	12	helix	helix	NN
cord-001835-0s7ok4uw	1556	13	bundle	bundle	NN
cord-001835-0s7ok4uw	1556	14	three	three	CD
cord-001835-0s7ok4uw	1556	15	-	-	HYPH
cord-001835-0s7ok4uw	1556	16	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	1556	17	fold	fold	NN
cord-001835-0s7ok4uw	1556	18	.	.	.
cord-001835-0s7ok4uw	1557	1	The	the	DT
cord-001835-0s7ok4uw	1557	2	goal	goal	NN
cord-001835-0s7ok4uw	1557	3	of	of	IN
cord-001835-0s7ok4uw	1557	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1557	5	work	work	NN
cord-001835-0s7ok4uw	1557	6	was	be	VBD
cord-001835-0s7ok4uw	1557	7	to	to	TO
cord-001835-0s7ok4uw	1557	8	determine	determine	VB
cord-001835-0s7ok4uw	1557	9	conformational	conformational	JJ
cord-001835-0s7ok4uw	1557	10	ensemble	ensemble	NN
cord-001835-0s7ok4uw	1557	11	of	of	IN
cord-001835-0s7ok4uw	1557	12	polypeptide	polypeptide	JJ
cord-001835-0s7ok4uw	1557	13	chain	chain	NN
cord-001835-0s7ok4uw	1557	14	of	of	IN
cord-001835-0s7ok4uw	1557	15	the	the	DT
cord-001835-0s7ok4uw	1557	16	investigated	investigate	VBN
cord-001835-0s7ok4uw	1557	17	miniprotein	miniprotein	NNP
cord-001835-0s7ok4uw	1557	18	at	at	IN
cord-001835-0s7ok4uw	1557	19	a	a	DT
cord-001835-0s7ok4uw	1557	20	wide	wide	JJ
cord-001835-0s7ok4uw	1557	21	range	range	NN
cord-001835-0s7ok4uw	1557	22	of	of	IN
cord-001835-0s7ok4uw	1557	23	temperatures	temperature	NNS
cord-001835-0s7ok4uw	1557	24	to	to	TO
cord-001835-0s7ok4uw	1557	25	get	get	VB
cord-001835-0s7ok4uw	1557	26	detailed	detailed	JJ
cord-001835-0s7ok4uw	1557	27	information	information	NN
cord-001835-0s7ok4uw	1557	28	about	about	IN
cord-001835-0s7ok4uw	1557	29	how	how	WRB
cord-001835-0s7ok4uw	1557	30	protein	protein	NN
cord-001835-0s7ok4uw	1557	31	structure	structure	NN
cord-001835-0s7ok4uw	1557	32	is	be	VBZ
cord-001835-0s7ok4uw	1557	33	influenced	influence	VBN
cord-001835-0s7ok4uw	1557	34	by	by	IN
cord-001835-0s7ok4uw	1557	35	temperature	temperature	NN
cord-001835-0s7ok4uw	1557	36	.	.	.
cord-001835-0s7ok4uw	1558	1	2D	2D	NNP
cord-001835-0s7ok4uw	1558	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	1558	3	spectra	spectrum	NNS
cord-001835-0s7ok4uw	1558	4	of	of	IN
cord-001835-0s7ok4uw	1558	5	the	the	DT
cord-001835-0s7ok4uw	1558	6	title	title	NN
cord-001835-0s7ok4uw	1558	7	miniprotein	miniprotein	NNP
cord-001835-0s7ok4uw	1558	8	were	be	VBD
cord-001835-0s7ok4uw	1558	9	registered	register	VBN
cord-001835-0s7ok4uw	1558	10	at	at	IN
cord-001835-0s7ok4uw	1558	11	278	278	CD
cord-001835-0s7ok4uw	1558	12	,	,	,
cord-001835-0s7ok4uw	1558	13	293	293	CD
cord-001835-0s7ok4uw	1558	14	and	and	CC
cord-001835-0s7ok4uw	1558	15	313	313	CD
cord-001835-0s7ok4uw	1558	16	K.	K.	NNP
cord-001835-0s7ok4uw	1559	1	The	the	DT
cord-001835-0s7ok4uw	1559	2	three	three	CD
cord-001835-0s7ok4uw	1559	3	-	-	HYPH
cord-001835-0s7ok4uw	1559	4	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	1559	5	structure	structure	NN
cord-001835-0s7ok4uw	1559	6	of	of	IN
cord-001835-0s7ok4uw	1559	7	the	the	DT
cord-001835-0s7ok4uw	1559	8	HP35	HP35	NNP
cord-001835-0s7ok4uw	1559	9	based	base	VBN
cord-001835-0s7ok4uw	1559	10	on	on	IN
cord-001835-0s7ok4uw	1559	11	restraints	restraint	NNS
cord-001835-0s7ok4uw	1559	12	derived	derive	VBN
cord-001835-0s7ok4uw	1559	13	from	from	IN
cord-001835-0s7ok4uw	1559	14	NMR	NMR	NNP
cord-001835-0s7ok4uw	1559	15	spectra	spectrum	NNS
cord-001835-0s7ok4uw	1559	16	registered	register	VBN
cord-001835-0s7ok4uw	1559	17	at	at	IN
cord-001835-0s7ok4uw	1559	18	278	278	CD
cord-001835-0s7ok4uw	1559	19	K	K	NNP
cord-001835-0s7ok4uw	1559	20	is	be	VBZ
cord-001835-0s7ok4uw	1559	21	almost	almost	RB
cord-001835-0s7ok4uw	1559	22	identical	identical	JJ
cord-001835-0s7ok4uw	1559	23	with	with	IN
cord-001835-0s7ok4uw	1559	24	structure	structure	NN
cord-001835-0s7ok4uw	1559	25	deposited	deposit	VBN
cord-001835-0s7ok4uw	1559	26	in	in	IN
cord-001835-0s7ok4uw	1559	27	the	the	DT
cord-001835-0s7ok4uw	1559	28	PDB	PDB	NNP
cord-001835-0s7ok4uw	1559	29	database	database	NN
cord-001835-0s7ok4uw	1559	30	in	in	IN
cord-001835-0s7ok4uw	1559	31	the	the	DT
cord-001835-0s7ok4uw	1559	32	record	record	NN
cord-001835-0s7ok4uw	1559	33	2F4	2f4	CD
cord-001835-0s7ok4uw	1559	34	K	K	NNP
cord-001835-0s7ok4uw	1559	35	[	[	-LRB-
cord-001835-0s7ok4uw	1559	36	2	2	CD
cord-001835-0s7ok4uw	1559	37	]	]	-RRB-
cord-001835-0s7ok4uw	1559	38	.	.	.
cord-001835-0s7ok4uw	1560	1	At	at	IN
cord-001835-0s7ok4uw	1560	2	higher	high	JJR
cord-001835-0s7ok4uw	1560	3	temperatures	temperature	NNS
cord-001835-0s7ok4uw	1560	4	(	(	-LRB-
cord-001835-0s7ok4uw	1560	5	293	293	CD
cord-001835-0s7ok4uw	1560	6	and	and	CC
cord-001835-0s7ok4uw	1560	7	313	313	CD
cord-001835-0s7ok4uw	1560	8	K	K	NNP
cord-001835-0s7ok4uw	1560	9	)	)	-RRB-
cord-001835-0s7ok4uw	1560	10	the	the	DT
cord-001835-0s7ok4uw	1560	11	general	general	JJ
cord-001835-0s7ok4uw	1560	12	shape	shape	NN
cord-001835-0s7ok4uw	1560	13	of	of	IN
cord-001835-0s7ok4uw	1560	14	the	the	DT
cord-001835-0s7ok4uw	1560	15	protein	protein	NN
cord-001835-0s7ok4uw	1560	16	remains	remain	VBZ
cord-001835-0s7ok4uw	1560	17	unchanged	unchanged	JJ
cord-001835-0s7ok4uw	1560	18	,	,	,
cord-001835-0s7ok4uw	1560	19	with	with	IN
cord-001835-0s7ok4uw	1560	20	well	well	RB
cord-001835-0s7ok4uw	1560	21	packed	packed	JJ
cord-001835-0s7ok4uw	1560	22	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	1560	23	core	core	NN
cord-001835-0s7ok4uw	1560	24	.	.	.
cord-001835-0s7ok4uw	1561	1	However	however	RB
cord-001835-0s7ok4uw	1561	2	,	,	,
cord-001835-0s7ok4uw	1561	3	with	with	IN
cord-001835-0s7ok4uw	1561	4	temperature	temperature	NN
cord-001835-0s7ok4uw	1561	5	increase	increase	NN
cord-001835-0s7ok4uw	1561	6	alpha	alpha	NN
cord-001835-0s7ok4uw	1561	7	-	-	HYPH
cord-001835-0s7ok4uw	1561	8	helices	helix	NNS
cord-001835-0s7ok4uw	1561	9	start	start	VBP
cord-001835-0s7ok4uw	1561	10	to	to	TO
cord-001835-0s7ok4uw	1561	11	melt	melt	VB
cord-001835-0s7ok4uw	1561	12	.	.	.
cord-001835-0s7ok4uw	1562	1	At	at	IN
cord-001835-0s7ok4uw	1562	2	313	313	CD
cord-001835-0s7ok4uw	1562	3	K	K	NNP
cord-001835-0s7ok4uw	1562	4	structure	structure	NN
cord-001835-0s7ok4uw	1562	5	of	of	IN
cord-001835-0s7ok4uw	1562	6	the	the	DT
cord-001835-0s7ok4uw	1562	7	protein	protein	NN
cord-001835-0s7ok4uw	1562	8	remains	remain	VBZ
cord-001835-0s7ok4uw	1562	9	compact	compact	JJ
cord-001835-0s7ok4uw	1562	10	and	and	CC
cord-001835-0s7ok4uw	1562	11	in	in	IN
cord-001835-0s7ok4uw	1562	12	general	general	JJ
cord-001835-0s7ok4uw	1562	13	shape	shape	NN
cord-001835-0s7ok4uw	1562	14	similar	similar	JJ
cord-001835-0s7ok4uw	1562	15	to	to	IN
cord-001835-0s7ok4uw	1562	16	structure	structure	NN
cord-001835-0s7ok4uw	1562	17	observed	observe	VBN
cord-001835-0s7ok4uw	1562	18	at	at	IN
cord-001835-0s7ok4uw	1562	19	278	278	CD
cord-001835-0s7ok4uw	1562	20	K	K	NNP
cord-001835-0s7ok4uw	1562	21	,	,	,
cord-001835-0s7ok4uw	1562	22	but	but	CC
cord-001835-0s7ok4uw	1562	23	none	none	NN
cord-001835-0s7ok4uw	1562	24	of	of	IN
cord-001835-0s7ok4uw	1562	25	the	the	DT
cord-001835-0s7ok4uw	1562	26	alpha	alpha	NN
cord-001835-0s7ok4uw	1562	27	-	-	HYPH
cord-001835-0s7ok4uw	1562	28	helices	helix	NNS
cord-001835-0s7ok4uw	1562	29	could	could	MD
cord-001835-0s7ok4uw	1562	30	be	be	VB
cord-001835-0s7ok4uw	1562	31	observed	observe	VBN
cord-001835-0s7ok4uw	1562	32	.	.	.
cord-001835-0s7ok4uw	1563	1	Results	result	NNS
cord-001835-0s7ok4uw	1563	2	obtained	obtain	VBN
cord-001835-0s7ok4uw	1563	3	for	for	IN
cord-001835-0s7ok4uw	1563	4	HP35	HP35	NNP
cord-001835-0s7ok4uw	1563	5	protein	protein	NN
cord-001835-0s7ok4uw	1564	1	are	be	VBP
cord-001835-0s7ok4uw	1564	2	in	in	IN
cord-001835-0s7ok4uw	1564	3	agreement	agreement	NN
cord-001835-0s7ok4uw	1564	4	with	with	IN
cord-001835-0s7ok4uw	1564	5	previous	previous	JJ
cord-001835-0s7ok4uw	1564	6	observation	observation	NN
cord-001835-0s7ok4uw	1564	7	for	for	IN
cord-001835-0s7ok4uw	1564	8	the	the	DT
cord-001835-0s7ok4uw	1564	9	Trp	Trp	NNP
cord-001835-0s7ok4uw	1564	10	-	-	HYPH
cord-001835-0s7ok4uw	1564	11	cage	cage	NN
cord-001835-0s7ok4uw	1564	12	miniprotein	miniprotein	NNP
cord-001835-0s7ok4uw	1564	13	[	[	-LRB-
cord-001835-0s7ok4uw	1564	14	3	3	CD
cord-001835-0s7ok4uw	1564	15	]	]	-RRB-
cord-001835-0s7ok4uw	1564	16	,	,	,
cord-001835-0s7ok4uw	1564	17	that	that	IN
cord-001835-0s7ok4uw	1564	18	with	with	IN
cord-001835-0s7ok4uw	1564	19	temperature	temperature	NN
cord-001835-0s7ok4uw	1564	20	increase	increase	VBP
cord-001835-0s7ok4uw	1564	21	regular	regular	JJ
cord-001835-0s7ok4uw	1564	22	secondary	secondary	JJ
cord-001835-0s7ok4uw	1564	23	structure	structure	NN
cord-001835-0s7ok4uw	1564	24	elements	element	NNS
cord-001835-0s7ok4uw	1564	25	melt	melt	VBP
cord-001835-0s7ok4uw	1564	26	first	first	RB
cord-001835-0s7ok4uw	1564	27	before	before	IN
cord-001835-0s7ok4uw	1564	28	the	the	DT
cord-001835-0s7ok4uw	1564	29	break	break	NN
cord-001835-0s7ok4uw	1564	30	-	-	HYPH
cord-001835-0s7ok4uw	1564	31	up	up	NN
cord-001835-0s7ok4uw	1564	32	of	of	IN
cord-001835-0s7ok4uw	1564	33	the	the	DT
cord-001835-0s7ok4uw	1564	34	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	1564	35	core	core	NN
cord-001835-0s7ok4uw	1564	36	of	of	IN
cord-001835-0s7ok4uw	1564	37	the	the	DT
cord-001835-0s7ok4uw	1564	38	protein	protein	NN
cord-001835-0s7ok4uw	1564	39	.	.	.
cord-001835-0s7ok4uw	1564	40	 	 	_SP
cord-001835-0s7ok4uw	1565	1	Biological	biological	JJ
cord-001835-0s7ok4uw	1565	2	membranes	membrane	NNS
cord-001835-0s7ok4uw	1565	3	provide	provide	VBP
cord-001835-0s7ok4uw	1565	4	a	a	DT
cord-001835-0s7ok4uw	1565	5	selective	selective	JJ
cord-001835-0s7ok4uw	1565	6	and	and	CC
cord-001835-0s7ok4uw	1565	7	chemically	chemically	RB
cord-001835-0s7ok4uw	1565	8	sealed	seal	VBN
cord-001835-0s7ok4uw	1565	9	barrier	barrier	NN
cord-001835-0s7ok4uw	1565	10	for	for	IN
cord-001835-0s7ok4uw	1565	11	cells	cell	NNS
cord-001835-0s7ok4uw	1565	12	.	.	.
cord-001835-0s7ok4uw	1566	1	Transport	transport	NN
cord-001835-0s7ok4uw	1566	2	of	of	IN
cord-001835-0s7ok4uw	1566	3	ions	ion	NNS
cord-001835-0s7ok4uw	1566	4	and	and	CC
cord-001835-0s7ok4uw	1566	5	small	small	JJ
cord-001835-0s7ok4uw	1566	6	molecules	molecule	NNS
cord-001835-0s7ok4uw	1566	7	across	across	IN
cord-001835-0s7ok4uw	1566	8	the	the	DT
cord-001835-0s7ok4uw	1566	9	membrane	membrane	NN
cord-001835-0s7ok4uw	1566	10	is	be	VBZ
cord-001835-0s7ok4uw	1566	11	mediated	mediate	VBN
cord-001835-0s7ok4uw	1566	12	by	by	IN
cord-001835-0s7ok4uw	1566	13	transporter	transporter	NN
cord-001835-0s7ok4uw	1566	14	proteins	protein	NNS
cord-001835-0s7ok4uw	1566	15	and	and	CC
cord-001835-0s7ok4uw	1566	16	the	the	DT
cord-001835-0s7ok4uw	1566	17	breakdown	breakdown	NN
cord-001835-0s7ok4uw	1566	18	of	of	IN
cord-001835-0s7ok4uw	1566	19	a	a	DT
cord-001835-0s7ok4uw	1566	20	cell	cell	NN
cord-001835-0s7ok4uw	1566	21	's	's	POS
cord-001835-0s7ok4uw	1566	22	ability	ability	NN
cord-001835-0s7ok4uw	1566	23	to	to	TO
cord-001835-0s7ok4uw	1566	24	produce	produce	VB
cord-001835-0s7ok4uw	1566	25	functionally	functionally	RB
cord-001835-0s7ok4uw	1566	26	folded	fold	VBN
cord-001835-0s7ok4uw	1566	27	membrane	membrane	NN
cord-001835-0s7ok4uw	1566	28	transport	transport	NN
cord-001835-0s7ok4uw	1566	29	proteins	protein	NNS
cord-001835-0s7ok4uw	1566	30	can	can	MD
cord-001835-0s7ok4uw	1566	31	lead	lead	VB
cord-001835-0s7ok4uw	1566	32	to	to	IN
cord-001835-0s7ok4uw	1566	33	dysfunction	dysfunction	NN
cord-001835-0s7ok4uw	1566	34	and	and	CC
cord-001835-0s7ok4uw	1566	35	has	have	VBZ
cord-001835-0s7ok4uw	1566	36	been	be	VBN
cord-001835-0s7ok4uw	1566	37	implicated	implicate	VBN
cord-001835-0s7ok4uw	1566	38	in	in	IN
cord-001835-0s7ok4uw	1566	39	many	many	JJ
cord-001835-0s7ok4uw	1566	40	diseases1	diseases1	NN
cord-001835-0s7ok4uw	1566	41	.	.	.
cord-001835-0s7ok4uw	1567	1	However	however	RB
cord-001835-0s7ok4uw	1567	2	little	little	JJ
cord-001835-0s7ok4uw	1567	3	is	be	VBZ
cord-001835-0s7ok4uw	1567	4	known	know	VBN
cord-001835-0s7ok4uw	1567	5	about	about	IN
cord-001835-0s7ok4uw	1567	6	the	the	DT
cord-001835-0s7ok4uw	1567	7	processes	process	NNS
cord-001835-0s7ok4uw	1567	8	that	that	WDT
cord-001835-0s7ok4uw	1567	9	govern	govern	VBP
cord-001835-0s7ok4uw	1567	10	the	the	DT
cord-001835-0s7ok4uw	1567	11	misfolding	misfolding	NN
cord-001835-0s7ok4uw	1567	12	of	of	IN
cord-001835-0s7ok4uw	1567	13	a	a	DT
cord-001835-0s7ok4uw	1567	14	-	-	HYPH
cord-001835-0s7ok4uw	1567	15	helical	helical	JJ
cord-001835-0s7ok4uw	1567	16	integral	integral	JJ
cord-001835-0s7ok4uw	1567	17	membrane	membrane	NN
cord-001835-0s7ok4uw	1567	18	proteins	protein	NNS
cord-001835-0s7ok4uw	1567	19	,	,	,
cord-001835-0s7ok4uw	1567	20	taking	take	VBG
cord-001835-0s7ok4uw	1567	21	into	into	IN
cord-001835-0s7ok4uw	1567	22	account	account	NN
cord-001835-0s7ok4uw	1567	23	that	that	IN
cord-001835-0s7ok4uw	1567	24	these	these	DT
cord-001835-0s7ok4uw	1567	25	proteins	protein	NNS
cord-001835-0s7ok4uw	1567	26	fold	fold	VBP
cord-001835-0s7ok4uw	1567	27	and	and	CC
cord-001835-0s7ok4uw	1567	28	maintain	maintain	VBP
cord-001835-0s7ok4uw	1567	29	functional	functional	JJ
cord-001835-0s7ok4uw	1567	30	structures	structure	NNS
cord-001835-0s7ok4uw	1567	31	within	within	IN
cord-001835-0s7ok4uw	1567	32	membranes	membrane	NNS
cord-001835-0s7ok4uw	1567	33	of	of	IN
cord-001835-0s7ok4uw	1567	34	various	various	JJ
cord-001835-0s7ok4uw	1567	35	organelles	organelle	NNS
cord-001835-0s7ok4uw	1567	36	.	.	.
cord-001835-0s7ok4uw	1568	1	The	the	DT
cord-001835-0s7ok4uw	1568	2	neurotransmitter	neurotransmitter	NN
cord-001835-0s7ok4uw	1568	3	sodium	sodium	NN
cord-001835-0s7ok4uw	1568	4	symporter	symporter	NN
cord-001835-0s7ok4uw	1568	5	(	(	-LRB-
cord-001835-0s7ok4uw	1568	6	NSS	NSS	NNP
cord-001835-0s7ok4uw	1568	7	)	)	-RRB-
cord-001835-0s7ok4uw	1568	8	protein	protein	NN
cord-001835-0s7ok4uw	1568	9	family	family	NN
cord-001835-0s7ok4uw	1568	10	is	be	VBZ
cord-001835-0s7ok4uw	1568	11	an	an	DT
cord-001835-0s7ok4uw	1568	12	example	example	NN
cord-001835-0s7ok4uw	1568	13	of	of	IN
cord-001835-0s7ok4uw	1568	14	a	a	DT
cord-001835-0s7ok4uw	1568	15	-	-	HYPH
cord-001835-0s7ok4uw	1568	16	helical	helical	JJ
cord-001835-0s7ok4uw	1568	17	transporter	transporter	NN
cord-001835-0s7ok4uw	1568	18	proteins	protein	NNS
cord-001835-0s7ok4uw	1568	19	.	.	.
cord-001835-0s7ok4uw	1569	1	The	the	DT
cord-001835-0s7ok4uw	1569	2	NSS	NSS	NNP
cord-001835-0s7ok4uw	1569	3	family	family	NN
cord-001835-0s7ok4uw	1569	4	encompasses	encompass	VBZ
cord-001835-0s7ok4uw	1569	5	a	a	DT
cord-001835-0s7ok4uw	1569	6	wide	wide	JJ
cord-001835-0s7ok4uw	1569	7	range	range	NN
cord-001835-0s7ok4uw	1569	8	of	of	IN
cord-001835-0s7ok4uw	1569	9	prokaryotic	prokaryotic	JJ
cord-001835-0s7ok4uw	1569	10	and	and	CC
cord-001835-0s7ok4uw	1569	11	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	1569	12	ion	ion	NN
cord-001835-0s7ok4uw	1569	13	-	-	HYPH
cord-001835-0s7ok4uw	1569	14	coupled	couple	VBN
cord-001835-0s7ok4uw	1569	15	transporters	transporter	NNS
cord-001835-0s7ok4uw	1569	16	that	that	WDT
cord-001835-0s7ok4uw	1569	17	regulate	regulate	VBP
cord-001835-0s7ok4uw	1569	18	the	the	DT
cord-001835-0s7ok4uw	1569	19	transport	transport	NN
cord-001835-0s7ok4uw	1569	20	of	of	IN
cord-001835-0s7ok4uw	1569	21	neurotransmitter	neurotransmitter	NN
cord-001835-0s7ok4uw	1569	22	molecules	molecule	NNS
cord-001835-0s7ok4uw	1569	23	whose	whose	WP$
cord-001835-0s7ok4uw	1569	24	dysfunction	dysfunction	NN
cord-001835-0s7ok4uw	1569	25	has	have	VBZ
cord-001835-0s7ok4uw	1569	26	been	be	VBN
cord-001835-0s7ok4uw	1569	27	implicated	implicate	VBN
cord-001835-0s7ok4uw	1569	28	in	in	IN
cord-001835-0s7ok4uw	1569	29	multiple	multiple	JJ
cord-001835-0s7ok4uw	1569	30	diseases	disease	NNS
cord-001835-0s7ok4uw	1569	31	and	and	CC
cord-001835-0s7ok4uw	1569	32	disor	disor	NN
cord-001835-0s7ok4uw	1569	33	-	-	HYPH
cord-001835-0s7ok4uw	1569	34	ders2	ders2	JJ
cord-001835-0s7ok4uw	1569	35	.	.	.
cord-001835-0s7ok4uw	1570	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1570	2	have	have	VBP
cord-001835-0s7ok4uw	1570	3	investigated	investigate	VBN
cord-001835-0s7ok4uw	1570	4	the	the	DT
cord-001835-0s7ok4uw	1570	5	folding	folding	NN
cord-001835-0s7ok4uw	1570	6	processes	process	NNS
cord-001835-0s7ok4uw	1570	7	of	of	IN
cord-001835-0s7ok4uw	1570	8	prokaryotic	prokaryotic	JJ
cord-001835-0s7ok4uw	1570	9	homologue	homologue	NN
cord-001835-0s7ok4uw	1570	10	of	of	IN
cord-001835-0s7ok4uw	1570	11	the	the	DT
cord-001835-0s7ok4uw	1570	12	NSS	NSS	NNP
cord-001835-0s7ok4uw	1570	13	family	family	NN
cord-001835-0s7ok4uw	1570	14	LeuT	LeuT	NNP
cord-001835-0s7ok4uw	1570	15	responsible	responsible	JJ
cord-001835-0s7ok4uw	1570	16	for	for	IN
cord-001835-0s7ok4uw	1570	17	the	the	DT
cord-001835-0s7ok4uw	1570	18	transport	transport	NN
cord-001835-0s7ok4uw	1570	19	of	of	IN
cord-001835-0s7ok4uw	1570	20	neurotransmitters	neurotransmitter	NNS
cord-001835-0s7ok4uw	1570	21	and	and	CC
cord-001835-0s7ok4uw	1570	22	amino	amino	JJ
cord-001835-0s7ok4uw	1570	23	acids	acid	NNS
cord-001835-0s7ok4uw	1570	24	to	to	IN
cord-001835-0s7ok4uw	1570	25	the	the	DT
cord-001835-0s7ok4uw	1570	26	sodium	sodium	NN
cord-001835-0s7ok4uw	1570	27	electrochemical	electrochemical	JJ
cord-001835-0s7ok4uw	1570	28	gradient	gradient	NN
cord-001835-0s7ok4uw	1570	29	.	.	.
cord-001835-0s7ok4uw	1571	1	Previously	previously	RB
cord-001835-0s7ok4uw	1571	2	folding	fold	VBG
cord-001835-0s7ok4uw	1571	3	processes	process	NNS
cord-001835-0s7ok4uw	1571	4	of	of	IN
cord-001835-0s7ok4uw	1571	5	membrane	membrane	NN
cord-001835-0s7ok4uw	1571	6	transporters	transporter	NNS
cord-001835-0s7ok4uw	1571	7	have	have	VBP
cord-001835-0s7ok4uw	1571	8	mainly	mainly	RB
cord-001835-0s7ok4uw	1571	9	been	be	VBN
cord-001835-0s7ok4uw	1571	10	characterised	characterise	VBN
cord-001835-0s7ok4uw	1571	11	within	within	IN
cord-001835-0s7ok4uw	1571	12	detergent	detergent	NN
cord-001835-0s7ok4uw	1571	13	micelles	micelle	NNS
cord-001835-0s7ok4uw	1571	14	.	.	.
cord-001835-0s7ok4uw	1572	1	However	however	RB
cord-001835-0s7ok4uw	1572	2	,	,	,
cord-001835-0s7ok4uw	1572	3	detergent	detergent	NN
cord-001835-0s7ok4uw	1572	4	micelles	micelle	NNS
cord-001835-0s7ok4uw	1572	5	are	be	VBP
cord-001835-0s7ok4uw	1572	6	not	not	RB
cord-001835-0s7ok4uw	1572	7	an	an	DT
cord-001835-0s7ok4uw	1572	8	accurate	accurate	JJ
cord-001835-0s7ok4uw	1572	9	depiction	depiction	NN
cord-001835-0s7ok4uw	1572	10	of	of	IN
cord-001835-0s7ok4uw	1572	11	the	the	DT
cord-001835-0s7ok4uw	1572	12	environment	environment	NN
cord-001835-0s7ok4uw	1572	13	of	of	IN
cord-001835-0s7ok4uw	1572	14	the	the	DT
cord-001835-0s7ok4uw	1572	15	membrane	membrane	NN
cord-001835-0s7ok4uw	1572	16	bilayer	bilayer	NN
cord-001835-0s7ok4uw	1572	17	,	,	,
cord-001835-0s7ok4uw	1572	18	with	with	IN
cord-001835-0s7ok4uw	1572	19	this	this	DT
cord-001835-0s7ok4uw	1572	20	in	in	IN
cord-001835-0s7ok4uw	1572	21	mind	mind	NN
cord-001835-0s7ok4uw	1572	22	we	-PRON-	PRP
cord-001835-0s7ok4uw	1572	23	have	have	VBP
cord-001835-0s7ok4uw	1572	24	also	also	RB
cord-001835-0s7ok4uw	1572	25	attempted	attempt	VBN
cord-001835-0s7ok4uw	1572	26	to	to	TO
cord-001835-0s7ok4uw	1572	27	investigate	investigate	VB
cord-001835-0s7ok4uw	1572	28	folding	folding	NN
cord-001835-0s7ok4uw	1572	29	processes	process	NNS
cord-001835-0s7ok4uw	1572	30	within	within	IN
cord-001835-0s7ok4uw	1572	31	a	a	DT
cord-001835-0s7ok4uw	1572	32	bilayer	bilayer	NN
cord-001835-0s7ok4uw	1572	33	PD-051	PD-051	NNP
cord-001835-0s7ok4uw	1572	34	NMR	NMR	NNP
cord-001835-0s7ok4uw	1572	35	Investigation	Investigation	NNP
cord-001835-0s7ok4uw	1572	36	of	of	IN
cord-001835-0s7ok4uw	1572	37	pH	pH	NNP
cord-001835-0s7ok4uw	1572	38	-	-	HYPH
cord-001835-0s7ok4uw	1572	39	induced	induce	VBN
cord-001835-0s7ok4uw	1572	40	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1572	41	of	of	IN
cord-001835-0s7ok4uw	1572	42	B	b	NN
cord-001835-0s7ok4uw	1572	43	domain	domain	NN
cord-001835-0s7ok4uw	1572	44	of	of	IN
cord-001835-0s7ok4uw	1572	45	an	an	DT
cord-001835-0s7ok4uw	1572	46	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	1572	47	Coli	Coli	NNP
cord-001835-0s7ok4uw	1572	48	mannitol	mannitol	NN
cord-001835-0s7ok4uw	1572	49	transporter	transporter	NN
cord-001835-0s7ok4uw	1572	50	II	II	NNP
cord-001835-0s7ok4uw	1572	51	Mannitol	Mannitol	NNP
cord-001835-0s7ok4uw	1572	52	in	in	IN
cord-001835-0s7ok4uw	1572	53	the	the	DT
cord-001835-0s7ok4uw	1572	54	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	1572	55	phosphotransferase	phosphotransferase	NN
cord-001835-0s7ok4uw	1572	56	system	system	NN
cord-001835-0s7ok4uw	1572	57	Kim	Kim	NNP
cord-001835-0s7ok4uw	1572	58	Gowoon	Gowoon	NNP
cord-001835-0s7ok4uw	1572	59	1	1	CD
cord-001835-0s7ok4uw	1572	60	,	,	,
cord-001835-0s7ok4uw	1572	61	Yu	Yu	NNP
cord-001835-0s7ok4uw	1572	62	Taekyung	Taekyung	NNP
cord-001835-0s7ok4uw	1572	63	1	1	CD
cord-001835-0s7ok4uw	1572	64	,	,	,
cord-001835-0s7ok4uw	1572	65	Suh	Suh	NNP
cord-001835-0s7ok4uw	1572	66	Jeongyong	Jeongyong	NNP
cord-001835-0s7ok4uw	1572	67	1	1	CD
cord-001835-0s7ok4uw	1572	68	1	1	CD
cord-001835-0s7ok4uw	1573	1	The	the	DT
cord-001835-0s7ok4uw	1573	2	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	1573	3	phosphotransferase	phosphotransferase	NN
cord-001835-0s7ok4uw	1573	4	system	system	NN
cord-001835-0s7ok4uw	1573	5	(	(	-LRB-
cord-001835-0s7ok4uw	1573	6	PTS	PTS	NNP
cord-001835-0s7ok4uw	1573	7	)	)	-RRB-
cord-001835-0s7ok4uw	1573	8	mediates	mediate	VBZ
cord-001835-0s7ok4uw	1573	9	sugar	sugar	NN
cord-001835-0s7ok4uw	1573	10	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	1573	11	and	and	CC
cord-001835-0s7ok4uw	1573	12	translocation	translocation	NN
cord-001835-0s7ok4uw	1573	13	across	across	IN
cord-001835-0s7ok4uw	1573	14	the	the	DT
cord-001835-0s7ok4uw	1573	15	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	1573	16	membrane	membrane	NN
cord-001835-0s7ok4uw	1573	17	.	.	.
cord-001835-0s7ok4uw	1574	1	Cytoplasmic	Cytoplasmic	NNP
cord-001835-0s7ok4uw	1574	2	B	B	NNP
cord-001835-0s7ok4uw	1574	3	domain	domain	NN
cord-001835-0s7ok4uw	1574	4	(	(	-LRB-
cord-001835-0s7ok4uw	1574	5	IIB	IIB	NNP
cord-001835-0s7ok4uw	1574	6	Mtl	Mtl	NNP
cord-001835-0s7ok4uw	1574	7	)	)	-RRB-
cord-001835-0s7ok4uw	1574	8	of	of	IN
cord-001835-0s7ok4uw	1574	9	the	the	DT
cord-001835-0s7ok4uw	1574	10	mannitol	mannitol	NN
cord-001835-0s7ok4uw	1574	11	transporter	transporter	NN
cord-001835-0s7ok4uw	1574	12	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1574	13	II	II	NNP
cord-001835-0s7ok4uw	1574	14	Mannitol	Mannitol	NNP
cord-001835-0s7ok4uw	1574	15	,	,	,
cord-001835-0s7ok4uw	1574	16	a	a	DT
cord-001835-0s7ok4uw	1574	17	PTS	PTS	NNP
cord-001835-0s7ok4uw	1574	18	family	family	NN
cord-001835-0s7ok4uw	1574	19	protein	protein	NN
cord-001835-0s7ok4uw	1574	20	,	,	,
cord-001835-0s7ok4uw	1574	21	delivers	deliver	VBZ
cord-001835-0s7ok4uw	1574	22	a	a	DT
cord-001835-0s7ok4uw	1574	23	phosphoryl	phosphoryl	NN
cord-001835-0s7ok4uw	1574	24	group	group	NN
cord-001835-0s7ok4uw	1574	25	from	from	IN
cord-001835-0s7ok4uw	1574	26	A	a	DT
cord-001835-0s7ok4uw	1574	27	domain	domain	NN
cord-001835-0s7ok4uw	1574	28	to	to	IN
cord-001835-0s7ok4uw	1574	29	an	an	DT
cord-001835-0s7ok4uw	1574	30	incoming	incoming	JJ
cord-001835-0s7ok4uw	1574	31	mannitol	mannitol	NN
cord-001835-0s7ok4uw	1574	32	that	that	WDT
cord-001835-0s7ok4uw	1574	33	is	be	VBZ
cord-001835-0s7ok4uw	1574	34	translocated	translocate	VBN
cord-001835-0s7ok4uw	1574	35	across	across	IN
cord-001835-0s7ok4uw	1574	36	the	the	DT
cord-001835-0s7ok4uw	1574	37	membrane	membrane	NN
cord-001835-0s7ok4uw	1574	38	.	.	.
cord-001835-0s7ok4uw	1575	1	IIB	IIB	NNP
cord-001835-0s7ok4uw	1575	2	Mtl	Mtl	NNP
cord-001835-0s7ok4uw	1575	3	is	be	VBZ
cord-001835-0s7ok4uw	1575	4	comprised	comprise	VBN
cord-001835-0s7ok4uw	1575	5	of	of	IN
cord-001835-0s7ok4uw	1575	6	a	a	DT
cord-001835-0s7ok4uw	1575	7	four	four	CD
cord-001835-0s7ok4uw	1575	8	-	-	HYPH
cord-001835-0s7ok4uw	1575	9	stranded	strand	VBN
cord-001835-0s7ok4uw	1575	10	ß	ß	NN
cord-001835-0s7ok4uw	1575	11	-	-	HYPH
cord-001835-0s7ok4uw	1575	12	sheet	sheet	NN
cord-001835-0s7ok4uw	1575	13	and	and	CC
cord-001835-0s7ok4uw	1575	14	three	three	CD
cord-001835-0s7ok4uw	1575	15	helices	helix	NNS
cord-001835-0s7ok4uw	1575	16	,	,	,
cord-001835-0s7ok4uw	1575	17	representing	represent	VBG
cord-001835-0s7ok4uw	1575	18	a	a	DT
cord-001835-0s7ok4uw	1575	19	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	1575	20	Rossmann	Rossmann	NNP
cord-001835-0s7ok4uw	1575	21	fold	fold	NN
cord-001835-0s7ok4uw	1575	22	.	.	.
cord-001835-0s7ok4uw	1576	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1576	2	found	find	VBD
cord-001835-0s7ok4uw	1576	3	that	that	IN
cord-001835-0s7ok4uw	1576	4	the	the	DT
cord-001835-0s7ok4uw	1576	5	IIB	IIB	NNP
cord-001835-0s7ok4uw	1576	6	Mtl	Mtl	NNP
cord-001835-0s7ok4uw	1576	7	of	of	IN
cord-001835-0s7ok4uw	1576	8	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	1576	9	coli	coli	NNS
cord-001835-0s7ok4uw	1576	10	unfolded	unfold	VBN
cord-001835-0s7ok4uw	1576	11	at	at	IN
cord-001835-0s7ok4uw	1576	12	a	a	DT
cord-001835-0s7ok4uw	1576	13	mildly	mildly	RB
cord-001835-0s7ok4uw	1576	14	acidic	acidic	JJ
cord-001835-0s7ok4uw	1576	15	condition	condition	NN
cord-001835-0s7ok4uw	1576	16	.	.	.
cord-001835-0s7ok4uw	1577	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1577	2	made	make	VBD
cord-001835-0s7ok4uw	1577	3	IIB	IIB	NNP
cord-001835-0s7ok4uw	1577	4	Mtl	Mtl	NNP
cord-001835-0s7ok4uw	1577	5	mutants	mutant	NNS
cord-001835-0s7ok4uw	1577	6	to	to	TO
cord-001835-0s7ok4uw	1577	7	investigate	investigate	VB
cord-001835-0s7ok4uw	1577	8	the	the	DT
cord-001835-0s7ok4uw	1577	9	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1577	10	of	of	IN
cord-001835-0s7ok4uw	1577	11	the	the	DT
cord-001835-0s7ok4uw	1577	12	pH	ph	NN
cord-001835-0s7ok4uw	1577	13	-	-	HYPH
cord-001835-0s7ok4uw	1577	14	induced	induce	VBN
cord-001835-0s7ok4uw	1577	15	unfolding	unfold	VBG
cord-001835-0s7ok4uw	1577	16	using	use	VBG
cord-001835-0s7ok4uw	1577	17	NMR	NMR	NNP
cord-001835-0s7ok4uw	1577	18	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1577	19	.	.	.
cord-001835-0s7ok4uw	1578	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1578	2	monitored	monitor	VBD
cord-001835-0s7ok4uw	1578	3	backbone	backbone	NN
cord-001835-0s7ok4uw	1578	4	amide	amide	NN
cord-001835-0s7ok4uw	1578	5	groups	group	NNS
cord-001835-0s7ok4uw	1578	6	and	and	CC
cord-001835-0s7ok4uw	1578	7	side	side	NN
cord-001835-0s7ok4uw	1578	8	chain	chain	NN
cord-001835-0s7ok4uw	1578	9	imidazole	imidazole	NN
cord-001835-0s7ok4uw	1578	10	groups	group	NNS
cord-001835-0s7ok4uw	1578	11	of	of	IN
cord-001835-0s7ok4uw	1578	12	histidine	histidine	NN
cord-001835-0s7ok4uw	1578	13	residues	residue	NNS
cord-001835-0s7ok4uw	1578	14	using	use	VBG
cord-001835-0s7ok4uw	1578	15	2D	2D	NNP
cord-001835-0s7ok4uw	1578	16	HSQC	HSQC	NNP
cord-001835-0s7ok4uw	1578	17	NMR	NMR	NNP
cord-001835-0s7ok4uw	1578	18	,	,	,
cord-001835-0s7ok4uw	1578	19	and	and	CC
cord-001835-0s7ok4uw	1578	20	pointed	point	VBD
cord-001835-0s7ok4uw	1578	21	out	out	RP
cord-001835-0s7ok4uw	1578	22	a	a	DT
cord-001835-0s7ok4uw	1578	23	potential	potential	JJ
cord-001835-0s7ok4uw	1578	24	histidine	histidine	NN
cord-001835-0s7ok4uw	1578	25	residue	residue	NN
cord-001835-0s7ok4uw	1578	26	that	that	WDT
cord-001835-0s7ok4uw	1578	27	might	may	MD
cord-001835-0s7ok4uw	1578	28	be	be	VB
cord-001835-0s7ok4uw	1578	29	responsible	responsible	JJ
cord-001835-0s7ok4uw	1578	30	for	for	IN
cord-001835-0s7ok4uw	1578	31	the	the	DT
cord-001835-0s7ok4uw	1578	32	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1578	33	.	.	.
cord-001835-0s7ok4uw	1579	1	Histidine	histidine	NN
cord-001835-0s7ok4uw	1579	2	residues	residue	NNS
cord-001835-0s7ok4uw	1579	3	may	may	MD
cord-001835-0s7ok4uw	1579	4	be	be	VB
cord-001835-0s7ok4uw	1579	5	generally	generally	RB
cord-001835-0s7ok4uw	1579	6	important	important	JJ
cord-001835-0s7ok4uw	1579	7	to	to	IN
cord-001835-0s7ok4uw	1579	8	the	the	DT
cord-001835-0s7ok4uw	1579	9	folding	folding	NN
cord-001835-0s7ok4uw	1579	10	stability	stability	NN
cord-001835-0s7ok4uw	1579	11	in	in	IN
cord-001835-0s7ok4uw	1579	12	response	response	NN
cord-001835-0s7ok4uw	1579	13	to	to	IN
cord-001835-0s7ok4uw	1579	14	environmental	environmental	JJ
cord-001835-0s7ok4uw	1579	15	pH	ph	NN
cord-001835-0s7ok4uw	1579	16	changes	change	NNS
cord-001835-0s7ok4uw	1579	17	.	.	.
cord-001835-0s7ok4uw	1580	1	Can	Can	MD
cord-001835-0s7ok4uw	1580	2	site	site	NN
cord-001835-0s7ok4uw	1580	3	-	-	HYPH
cord-001835-0s7ok4uw	1580	4	directed	direct	VBN
cord-001835-0s7ok4uw	1580	5	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	1580	6	shed	shed	VBD
cord-001835-0s7ok4uw	1580	7	light	light	NN
cord-001835-0s7ok4uw	1580	8	on	on	IN
cord-001835-0s7ok4uw	1580	9	the	the	DT
cord-001835-0s7ok4uw	1580	10	refolding	refolding	JJ
cord-001835-0s7ok4uw	1580	11	pattern	pattern	NN
cord-001835-0s7ok4uw	1580	12	of	of	IN
cord-001835-0s7ok4uw	1580	13	human	human	JJ
cord-001835-0s7ok4uw	1580	14	glucose	glucose	NN
cord-001835-0s7ok4uw	1580	15	6-phosphate	6-phosphate	NN
cord-001835-0s7ok4uw	1580	16	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	1580	17	(	(	-LRB-
cord-001835-0s7ok4uw	1580	18	G6PD	G6PD	NNP
cord-001835-0s7ok4uw	1580	19	)	)	-RRB-
cord-001835-0s7ok4uw	1580	20	?	?	.
cord-001835-0s7ok4uw	1581	1	Nurriza	Nurriza	NNP
cord-001835-0s7ok4uw	1581	2	Ab	Ab	NNP
cord-001835-0s7ok4uw	1581	3	Latif	Latif	NNP
cord-001835-0s7ok4uw	1581	4	1,2	1,2	CD
cord-001835-0s7ok4uw	1582	1	,	,	,
cord-001835-0s7ok4uw	1582	2	Paul	Paul	NNP
cord-001835-0s7ok4uw	1582	3	Engel	Engel	NNP
cord-001835-0s7ok4uw	1582	4	1	1	CD
cord-001835-0s7ok4uw	1582	5	1	1	CD
cord-001835-0s7ok4uw	1582	6	Conway	Conway	NNP
cord-001835-0s7ok4uw	1582	7	Institute	Institute	NNP
cord-001835-0s7ok4uw	1582	8	,	,	,
cord-001835-0s7ok4uw	1582	9	Univerversity	Univerversity	NNP
cord-001835-0s7ok4uw	1582	10	College	College	NNP
cord-001835-0s7ok4uw	1582	11	Dublin	Dublin	NNP
cord-001835-0s7ok4uw	1582	12	,	,	,
cord-001835-0s7ok4uw	1582	13	2	2	CD
cord-001835-0s7ok4uw	1582	14	Faculty	Faculty	NNP
cord-001835-0s7ok4uw	1582	15	of	of	IN
cord-001835-0s7ok4uw	1582	16	Biosciences	Biosciences	NNPS
cord-001835-0s7ok4uw	1582	17	and	and	CC
cord-001835-0s7ok4uw	1582	18	Medical	Medical	NNP
cord-001835-0s7ok4uw	1582	19	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	1582	20	,	,	,
cord-001835-0s7ok4uw	1582	21	Universiti	Universiti	NNP
cord-001835-0s7ok4uw	1582	22	Teknologi	Teknologi	NNP
cord-001835-0s7ok4uw	1582	23	Malaysia	Malaysia	NNP
cord-001835-0s7ok4uw	1582	24	Human	Human	NNP
cord-001835-0s7ok4uw	1582	25	glucose	glucose	NN
cord-001835-0s7ok4uw	1582	26	6-phosphate	6-phosphate	NN
cord-001835-0s7ok4uw	1582	27	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	1582	28	(	(	-LRB-
cord-001835-0s7ok4uw	1582	29	G6PD	G6PD	NNP
cord-001835-0s7ok4uw	1582	30	)	)	-RRB-
cord-001835-0s7ok4uw	1582	31	is	be	VBZ
cord-001835-0s7ok4uw	1582	32	the	the	DT
cord-001835-0s7ok4uw	1582	33	first	first	JJ
cord-001835-0s7ok4uw	1582	34	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1582	35	involved	involve	VBN
cord-001835-0s7ok4uw	1582	36	in	in	IN
cord-001835-0s7ok4uw	1582	37	the	the	DT
cord-001835-0s7ok4uw	1582	38	pentose	pentose	NN
cord-001835-0s7ok4uw	1582	39	phosphate	phosphate	NN
cord-001835-0s7ok4uw	1582	40	pathway	pathway	NN
cord-001835-0s7ok4uw	1582	41	(	(	-LRB-
cord-001835-0s7ok4uw	1582	42	PPP	PPP	NNP
cord-001835-0s7ok4uw	1582	43	)	)	-RRB-
cord-001835-0s7ok4uw	1582	44	.	.	.
cord-001835-0s7ok4uw	1583	1	This	this	DT
cord-001835-0s7ok4uw	1583	2	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	1583	3	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1583	4	catalyses	catalyse	VBZ
cord-001835-0s7ok4uw	1583	5	the	the	DT
cord-001835-0s7ok4uw	1583	6	reaction	reaction	NN
cord-001835-0s7ok4uw	1583	7	of	of	IN
cord-001835-0s7ok4uw	1583	8	glucose	glucose	NN
cord-001835-0s7ok4uw	1583	9	6-phosphate	6-phosphate	NN
cord-001835-0s7ok4uw	1583	10	to	to	TO
cord-001835-0s7ok4uw	1583	11	form	form	VB
cord-001835-0s7ok4uw	1583	12	6phosphogluconolactone	6phosphogluconolactone	CD
cord-001835-0s7ok4uw	1583	13	with	with	IN
cord-001835-0s7ok4uw	1583	14	concomitant	concomitant	JJ
cord-001835-0s7ok4uw	1583	15	reduction	reduction	NN
cord-001835-0s7ok4uw	1583	16	of	of	IN
cord-001835-0s7ok4uw	1583	17	NADP1	nadp1	NN
cord-001835-0s7ok4uw	1583	18	to	to	IN
cord-001835-0s7ok4uw	1583	19	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	1583	20	.	.	.
cord-001835-0s7ok4uw	1584	1	In	in	IN
cord-001835-0s7ok4uw	1584	2	erythrocytes	erythrocyte	NNS
cord-001835-0s7ok4uw	1584	3	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	1584	4	is	be	VBZ
cord-001835-0s7ok4uw	1584	5	important	important	JJ
cord-001835-0s7ok4uw	1584	6	mainly	mainly	RB
cord-001835-0s7ok4uw	1584	7	for	for	IN
cord-001835-0s7ok4uw	1584	8	protection	protection	NN
cord-001835-0s7ok4uw	1584	9	against	against	IN
cord-001835-0s7ok4uw	1584	10	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	1584	11	stress	stress	NN
cord-001835-0s7ok4uw	1584	12	.	.	.
cord-001835-0s7ok4uw	1585	1	In	in	IN
cord-001835-0s7ok4uw	1585	2	connection	connection	NN
cord-001835-0s7ok4uw	1585	3	with	with	IN
cord-001835-0s7ok4uw	1585	4	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1585	5	role	role	NN
cord-001835-0s7ok4uw	1585	6	as	as	IN
cord-001835-0s7ok4uw	1585	7	the	the	DT
cord-001835-0s7ok4uw	1585	8	sole	sole	JJ
cord-001835-0s7ok4uw	1585	9	source	source	NN
cord-001835-0s7ok4uw	1585	10	of	of	IN
cord-001835-0s7ok4uw	1585	11	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	1585	12	,	,	,
cord-001835-0s7ok4uw	1585	13	G6PD	G6PD	NNP
cord-001835-0s7ok4uw	1585	14	deficiency	deficiency	NN
cord-001835-0s7ok4uw	1585	15	commonly	commonly	RB
cord-001835-0s7ok4uw	1585	16	causes	cause	VBZ
cord-001835-0s7ok4uw	1585	17	haemolytic	haemolytic	JJ
cord-001835-0s7ok4uw	1585	18	disease	disease	NN
cord-001835-0s7ok4uw	1585	19	and	and	CC
cord-001835-0s7ok4uw	1585	20	is	be	VBZ
cord-001835-0s7ok4uw	1585	21	known	know	VBN
cord-001835-0s7ok4uw	1585	22	as	as	IN
cord-001835-0s7ok4uw	1585	23	the	the	DT
cord-001835-0s7ok4uw	1585	24	most	most	RBS
cord-001835-0s7ok4uw	1585	25	common	common	JJ
cord-001835-0s7ok4uw	1585	26	human	human	JJ
cord-001835-0s7ok4uw	1585	27	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1585	28	deficiency	deficiency	NN
cord-001835-0s7ok4uw	1585	29	globally	globally	RB
cord-001835-0s7ok4uw	1585	30	.	.	.
cord-001835-0s7ok4uw	1586	1	Protein	protein	NN
cord-001835-0s7ok4uw	1586	2	folding	folding	NN
cord-001835-0s7ok4uw	1586	3	problems	problem	NNS
cord-001835-0s7ok4uw	1586	4	and	and	CC
cord-001835-0s7ok4uw	1586	5	instability	instability	NN
cord-001835-0s7ok4uw	1586	6	are	be	VBP
cord-001835-0s7ok4uw	1586	7	believed	believe	VBN
cord-001835-0s7ok4uw	1586	8	to	to	TO
cord-001835-0s7ok4uw	1586	9	be	be	VB
cord-001835-0s7ok4uw	1586	10	the	the	DT
cord-001835-0s7ok4uw	1586	11	major	major	JJ
cord-001835-0s7ok4uw	1586	12	defects	defect	NNS
cord-001835-0s7ok4uw	1586	13	in	in	IN
cord-001835-0s7ok4uw	1586	14	the	the	DT
cord-001835-0s7ok4uw	1586	15	deficient	deficient	JJ
cord-001835-0s7ok4uw	1586	16	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	1586	17	.	.	.
cord-001835-0s7ok4uw	1587	1	In	in	IN
cord-001835-0s7ok4uw	1587	2	this	this	DT
cord-001835-0s7ok4uw	1587	3	study	study	NN
cord-001835-0s7ok4uw	1587	4	,	,	,
cord-001835-0s7ok4uw	1587	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1587	6	employed	employ	VBD
cord-001835-0s7ok4uw	1587	7	site	site	NN
cord-001835-0s7ok4uw	1587	8	directed	direct	VBN
cord-001835-0s7ok4uw	1587	9	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	1587	10	with	with	IN
cord-001835-0s7ok4uw	1587	11	hope	hope	NN
cord-001835-0s7ok4uw	1587	12	to	to	TO
cord-001835-0s7ok4uw	1587	13	give	give	VB
cord-001835-0s7ok4uw	1587	14	more	more	JJR
cord-001835-0s7ok4uw	1587	15	information	information	NN
cord-001835-0s7ok4uw	1587	16	on	on	IN
cord-001835-0s7ok4uw	1587	17	the	the	DT
cord-001835-0s7ok4uw	1587	18	role	role	NN
cord-001835-0s7ok4uw	1587	19	of	of	IN
cord-001835-0s7ok4uw	1587	20	-SH	-SH	NNS
cord-001835-0s7ok4uw	1587	21	groups	group	NNS
cord-001835-0s7ok4uw	1587	22	in	in	IN
cord-001835-0s7ok4uw	1587	23	the	the	DT
cord-001835-0s7ok4uw	1587	24	refolding	refolding	NN
cord-001835-0s7ok4uw	1587	25	of	of	IN
cord-001835-0s7ok4uw	1587	26	human	human	JJ
cord-001835-0s7ok4uw	1587	27	G6PD	G6PD	NNP
cord-001835-0s7ok4uw	1587	28	.	.	.
cord-001835-0s7ok4uw	1588	1	Two	two	CD
cord-001835-0s7ok4uw	1588	2	mutants	mutant	NNS
cord-001835-0s7ok4uw	1588	3	were	be	VBD
cord-001835-0s7ok4uw	1588	4	created	create	VBN
cord-001835-0s7ok4uw	1588	5	:	:	:
cord-001835-0s7ok4uw	1588	6	1	1	LS
cord-001835-0s7ok4uw	1588	7	)	)	-RRB-
cord-001835-0s7ok4uw	1588	8	one	one	CD
cord-001835-0s7ok4uw	1588	9	in	in	IN
cord-001835-0s7ok4uw	1588	10	which	which	WDT
cord-001835-0s7ok4uw	1588	11	all	all	DT
cord-001835-0s7ok4uw	1588	12	8	8	CD
cord-001835-0s7ok4uw	1588	13	Cys	Cys	NNP
cord-001835-0s7ok4uw	1588	14	residues	residue	NNS
cord-001835-0s7ok4uw	1588	15	were	be	VBD
cord-001835-0s7ok4uw	1588	16	replaced	replace	VBN
cord-001835-0s7ok4uw	1588	17	by	by	IN
cord-001835-0s7ok4uw	1588	18	Ser	Ser	NNP
cord-001835-0s7ok4uw	1588	19	and	and	CC
cord-001835-0s7ok4uw	1588	20	2	2	CD
cord-001835-0s7ok4uw	1588	21	)	)	-RRB-
cord-001835-0s7ok4uw	1588	22	one	one	CD
cord-001835-0s7ok4uw	1588	23	in	in	IN
cord-001835-0s7ok4uw	1588	24	which	which	WDT
cord-001835-0s7ok4uw	1588	25	only	only	RB
cord-001835-0s7ok4uw	1588	26	C13	C13	NNP
cord-001835-0s7ok4uw	1588	27	and	and	CC
cord-001835-0s7ok4uw	1588	28	C446	C446	NNPS
cord-001835-0s7ok4uw	1588	29	were	be	VBD
cord-001835-0s7ok4uw	1588	30	retained	retain	VBN
cord-001835-0s7ok4uw	1588	31	.	.	.
cord-001835-0s7ok4uw	1589	1	The	the	DT
cord-001835-0s7ok4uw	1589	2	refolding	refolding	NN
cord-001835-0s7ok4uw	1589	3	of	of	IN
cord-001835-0s7ok4uw	1589	4	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1589	5	human	human	JJ
cord-001835-0s7ok4uw	1589	6	G6PD	G6PD	NNP
cord-001835-0s7ok4uw	1589	7	has	have	VBZ
cord-001835-0s7ok4uw	1589	8	been	be	VBN
cord-001835-0s7ok4uw	1589	9	studied	study	VBN
cord-001835-0s7ok4uw	1589	10	primarily	primarily	RB
cord-001835-0s7ok4uw	1589	11	by	by	IN
cord-001835-0s7ok4uw	1589	12	measuring	measure	VBG
cord-001835-0s7ok4uw	1589	13	the	the	DT
cord-001835-0s7ok4uw	1589	14	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1589	15	activity	activity	NN
cord-001835-0s7ok4uw	1589	16	after	after	IN
cord-001835-0s7ok4uw	1589	17	refolding	refolde	VBG
cord-001835-0s7ok4uw	1589	18	.	.	.
cord-001835-0s7ok4uw	1590	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1590	2	also	also	RB
cord-001835-0s7ok4uw	1590	3	used	use	VBD
cord-001835-0s7ok4uw	1590	4	a	a	DT
cord-001835-0s7ok4uw	1590	5	combination	combination	NN
cord-001835-0s7ok4uw	1590	6	of	of	IN
cord-001835-0s7ok4uw	1590	7	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	1590	8	protein	protein	NN
cord-001835-0s7ok4uw	1590	9	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1590	10	,	,	,
cord-001835-0s7ok4uw	1590	11	ANS	ANS	NNP
cord-001835-0s7ok4uw	1590	12	(	(	-LRB-
cord-001835-0s7ok4uw	1590	13	8-anilino-1-naphthalenesulphonic	8-anilino-1-naphthalenesulphonic	CD
cord-001835-0s7ok4uw	1590	14	acid	acid	NN
cord-001835-0s7ok4uw	1590	15	)	)	-RRB-
cord-001835-0s7ok4uw	1590	16	binding	bind	VBG
cord-001835-0s7ok4uw	1590	17	and	and	CC
cord-001835-0s7ok4uw	1590	18	limited	limited	JJ
cord-001835-0s7ok4uw	1590	19	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	1590	20	to	to	TO
cord-001835-0s7ok4uw	1590	21	look	look	VB
cord-001835-0s7ok4uw	1590	22	at	at	IN
cord-001835-0s7ok4uw	1590	23	the	the	DT
cord-001835-0s7ok4uw	1590	24	conformational	conformational	JJ
cord-001835-0s7ok4uw	1590	25	change	change	NN
cord-001835-0s7ok4uw	1590	26	during	during	IN
cord-001835-0s7ok4uw	1590	27	the	the	DT
cord-001835-0s7ok4uw	1590	28	refolding	refolding	NN
cord-001835-0s7ok4uw	1590	29	.	.	.
cord-001835-0s7ok4uw	1591	1	The	the	DT
cord-001835-0s7ok4uw	1591	2	results	result	NNS
cord-001835-0s7ok4uw	1591	3	showed	show	VBD
cord-001835-0s7ok4uw	1591	4	that	that	IN
cord-001835-0s7ok4uw	1591	5	GdnHCl	gdnhcl	NN
cord-001835-0s7ok4uw	1591	6	-	-	HYPH
cord-001835-0s7ok4uw	1591	7	denatured	denature	VBN
cord-001835-0s7ok4uw	1591	8	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1591	9	human	human	NN
cord-001835-0s7ok4uw	1591	10	G6PD	G6PD	NNP
cord-001835-0s7ok4uw	1591	11	wild	wild	JJ
cord-001835-0s7ok4uw	1591	12	type	type	NN
cord-001835-0s7ok4uw	1591	13	could	could	MD
cord-001835-0s7ok4uw	1591	14	be	be	VB
cord-001835-0s7ok4uw	1591	15	refolded	refolde	VBN
cord-001835-0s7ok4uw	1591	16	and	and	CC
cord-001835-0s7ok4uw	1591	17	reactivated	reactivate	VBN
cord-001835-0s7ok4uw	1591	18	by	by	IN
cord-001835-0s7ok4uw	1591	19	rapid	rapid	JJ
cord-001835-0s7ok4uw	1591	20	dilution	dilution	NN
cord-001835-0s7ok4uw	1591	21	technique	technique	NN
cord-001835-0s7ok4uw	1591	22	.	.	.
cord-001835-0s7ok4uw	1592	1	Even	even	RB
cord-001835-0s7ok4uw	1592	2	though	though	RB
cord-001835-0s7ok4uw	1592	3	,	,	,
cord-001835-0s7ok4uw	1592	4	as	as	IN
cord-001835-0s7ok4uw	1592	5	recombinants	recombinant	NNS
cord-001835-0s7ok4uw	1592	6	in	in	IN
cord-001835-0s7ok4uw	1592	7	E.	E.	NNP
cord-001835-0s7ok4uw	1592	8	coli	coli	NNS
cord-001835-0s7ok4uw	1592	9	,	,	,
cord-001835-0s7ok4uw	1592	10	the	the	DT
cord-001835-0s7ok4uw	1592	11	mutants	mutant	NNS
cord-001835-0s7ok4uw	1592	12	were	be	VBD
cord-001835-0s7ok4uw	1592	13	well	well	RB
cord-001835-0s7ok4uw	1592	14	expressed	expressed	JJ
cord-001835-0s7ok4uw	1592	15	and	and	CC
cord-001835-0s7ok4uw	1592	16	active	active	JJ
cord-001835-0s7ok4uw	1592	17	,	,	,
cord-001835-0s7ok4uw	1592	18	they	-PRON-	PRP
cord-001835-0s7ok4uw	1592	19	remained	remain	VBD
cord-001835-0s7ok4uw	1592	20	inactive	inactive	JJ
cord-001835-0s7ok4uw	1592	21	after	after	IN
cord-001835-0s7ok4uw	1592	22	attempts	attempt	NNS
cord-001835-0s7ok4uw	1592	23	were	be	VBD
cord-001835-0s7ok4uw	1592	24	made	make	VBN
cord-001835-0s7ok4uw	1592	25	to	to	TO
cord-001835-0s7ok4uw	1592	26	refold	refold	VB
cord-001835-0s7ok4uw	1592	27	them	-PRON-	PRP
cord-001835-0s7ok4uw	1592	28	in	in	IN
cord-001835-0s7ok4uw	1592	29	vitro	vitro	FW
cord-001835-0s7ok4uw	1592	30	.	.	.
cord-001835-0s7ok4uw	1593	1	The	the	DT
cord-001835-0s7ok4uw	1593	2	methods	method	NNS
cord-001835-0s7ok4uw	1593	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1593	4	applied	apply	VBD
cord-001835-0s7ok4uw	1593	5	may	may	MD
cord-001835-0s7ok4uw	1593	6	have	have	VB
cord-001835-0s7ok4uw	1593	7	provided	provide	VBN
cord-001835-0s7ok4uw	1593	8	some	some	DT
cord-001835-0s7ok4uw	1593	9	insights	insight	NNS
cord-001835-0s7ok4uw	1593	10	on	on	IN
cord-001835-0s7ok4uw	1593	11	the	the	DT
cord-001835-0s7ok4uw	1593	12	refolding	refolding	JJ
cord-001835-0s7ok4uw	1593	13	pattern	pattern	NN
cord-001835-0s7ok4uw	1593	14	of	of	IN
cord-001835-0s7ok4uw	1593	15	this	this	DT
cord-001835-0s7ok4uw	1593	16	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	1593	17	protein	protein	NN
cord-001835-0s7ok4uw	1593	18	,	,	,
cord-001835-0s7ok4uw	1593	19	albeit	albeit	RB
cord-001835-0s7ok4uw	1593	20	qualitatively	qualitatively	RB
cord-001835-0s7ok4uw	1593	21	rather	rather	RB
cord-001835-0s7ok4uw	1593	22	than	than	IN
cord-001835-0s7ok4uw	1593	23	quantitatively	quantitatively	RB
cord-001835-0s7ok4uw	1593	24	.	.	.
cord-001835-0s7ok4uw	1594	1	A	a	DT
cord-001835-0s7ok4uw	1594	2	single	single	JJ
cord-001835-0s7ok4uw	1594	3	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	1594	4	core	core	NN
cord-001835-0s7ok4uw	1594	5	mutation	mutation	NN
cord-001835-0s7ok4uw	1594	6	converts	convert	VBZ
cord-001835-0s7ok4uw	1594	7	a	a	DT
cord-001835-0s7ok4uw	1594	8	designed	design	VBN
cord-001835-0s7ok4uw	1594	9	'	'	``
cord-001835-0s7ok4uw	1594	10	primitive	primitive	JJ
cord-001835-0s7ok4uw	1594	11	'	'	''
cord-001835-0s7ok4uw	1594	12	protein	protein	NN
cord-001835-0s7ok4uw	1594	13	from	from	IN
cord-001835-0s7ok4uw	1594	14	halophile	halophile	NNP
cord-001835-0s7ok4uw	1594	15	to	to	IN
cord-001835-0s7ok4uw	1594	16	mesophile	mesophile	VB
cord-001835-0s7ok4uw	1594	17	folding	fold	VBG
cord-001835-0s7ok4uw	1594	18	Connie	Connie	NNP
cord-001835-0s7ok4uw	1594	19	Tenorio	Tenorio	NNP
cord-001835-0s7ok4uw	1594	20	1	1	CD
cord-001835-0s7ok4uw	1594	21	,	,	,
cord-001835-0s7ok4uw	1594	22	Liam	Liam	NNP
cord-001835-0s7ok4uw	1594	23	Longo	Longo	NNP
cord-001835-0s7ok4uw	1594	24	1	1	CD
cord-001835-0s7ok4uw	1594	25	,	,	,
cord-001835-0s7ok4uw	1594	26	Ozan	Ozan	NNP
cord-001835-0s7ok4uw	1594	27	S.	S.	NNP
cord-001835-0s7ok4uw	1594	28	Kumru	Kumru	NNP
cord-001835-0s7ok4uw	1594	29	2	2	CD
cord-001835-0s7ok4uw	1594	30	,	,	,
cord-001835-0s7ok4uw	1594	31	C.	C.	NNP
cord-001835-0s7ok4uw	1594	32	Russell	Russell	NNP
cord-001835-0s7ok4uw	1594	33	Middaugh	Middaugh	NNP
cord-001835-0s7ok4uw	1594	34	2	2	CD
cord-001835-0s7ok4uw	1594	35	,	,	,
cord-001835-0s7ok4uw	1594	36	Michael	Michael	NNP
cord-001835-0s7ok4uw	1594	37	Blaber	Blaber	NNP
cord-001835-0s7ok4uw	1594	38	1	1	CD
cord-001835-0s7ok4uw	1594	39	1	1	CD
cord-001835-0s7ok4uw	1594	40	Department	Department	NNP
cord-001835-0s7ok4uw	1594	41	of	of	IN
cord-001835-0s7ok4uw	1594	42	Biomedical	Biomedical	NNP
cord-001835-0s7ok4uw	1594	43	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	1594	44	,	,	,
cord-001835-0s7ok4uw	1594	45	Florida	Florida	NNP
cord-001835-0s7ok4uw	1594	46	State	State	NNP
cord-001835-0s7ok4uw	1594	47	University	University	NNP
cord-001835-0s7ok4uw	1594	48	,	,	,
cord-001835-0s7ok4uw	1594	49	2	2	CD
cord-001835-0s7ok4uw	1594	50	Department	Department	NNP
cord-001835-0s7ok4uw	1594	51	of	of	IN
cord-001835-0s7ok4uw	1594	52	Pharmaceutical	Pharmaceutical	NNP
cord-001835-0s7ok4uw	1594	53	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	1594	54	,	,	,
cord-001835-0s7ok4uw	1594	55	University	University	NNP
cord-001835-0s7ok4uw	1594	56	of	of	IN
cord-001835-0s7ok4uw	1594	57	Kansas	Kansas	NNP
cord-001835-0s7ok4uw	1594	58	Experiments	Experiments	NNPS
cord-001835-0s7ok4uw	1594	59	in	in	IN
cord-001835-0s7ok4uw	1594	60	prebiotic	prebiotic	JJ
cord-001835-0s7ok4uw	1594	61	protein	protein	NN
cord-001835-0s7ok4uw	1594	62	design	design	NN
cord-001835-0s7ok4uw	1594	63	suggest	suggest	VBP
cord-001835-0s7ok4uw	1594	64	that	that	IN
cord-001835-0s7ok4uw	1594	65	the	the	DT
cord-001835-0s7ok4uw	1594	66	origin	origin	NN
cord-001835-0s7ok4uw	1594	67	of	of	IN
cord-001835-0s7ok4uw	1594	68	folded	folded	JJ
cord-001835-0s7ok4uw	1594	69	proteins	protein	NNS
cord-001835-0s7ok4uw	1594	70	may	may	MD
cord-001835-0s7ok4uw	1594	71	have	have	VB
cord-001835-0s7ok4uw	1594	72	favored	favor	VBN
cord-001835-0s7ok4uw	1594	73	halophile	halophile	NNP
cord-001835-0s7ok4uw	1594	74	conditions	condition	NNS
cord-001835-0s7ok4uw	1594	75	.	.	.
cord-001835-0s7ok4uw	1595	1	These	these	DT
cord-001835-0s7ok4uw	1595	2	results	result	NNS
cord-001835-0s7ok4uw	1595	3	are	be	VBP
cord-001835-0s7ok4uw	1595	4	consistent	consistent	JJ
cord-001835-0s7ok4uw	1595	5	with	with	IN
cord-001835-0s7ok4uw	1595	6	salt	salt	NN
cord-001835-0s7ok4uw	1595	7	induced	induce	VBN
cord-001835-0s7ok4uw	1595	8	peptide	peptide	NN
cord-001835-0s7ok4uw	1595	9	formation	formation	NN
cord-001835-0s7ok4uw	1595	10	which	which	WDT
cord-001835-0s7ok4uw	1595	11	shows	show	VBZ
cord-001835-0s7ok4uw	1595	12	that	that	IN
cord-001835-0s7ok4uw	1595	13	polymerization	polymerization	NN
cord-001835-0s7ok4uw	1595	14	of	of	IN
cord-001835-0s7ok4uw	1595	15	amino	amino	JJ
cord-001835-0s7ok4uw	1595	16	acids	acid	NNS
cord-001835-0s7ok4uw	1595	17	is	be	VBZ
cord-001835-0s7ok4uw	1595	18	also	also	RB
cord-001835-0s7ok4uw	1595	19	promoted	promote	VBN
cord-001835-0s7ok4uw	1595	20	by	by	IN
cord-001835-0s7ok4uw	1595	21	high	high	JJ
cord-001835-0s7ok4uw	1595	22	salt	salt	NN
cord-001835-0s7ok4uw	1595	23	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1595	24	.	.	.
cord-001835-0s7ok4uw	1596	1	As	as	IN
cord-001835-0s7ok4uw	1596	2	a	a	DT
cord-001835-0s7ok4uw	1596	3	result	result	NN
cord-001835-0s7ok4uw	1596	4	of	of	IN
cord-001835-0s7ok4uw	1596	5	various	various	JJ
cord-001835-0s7ok4uw	1596	6	origin	origin	NN
cord-001835-0s7ok4uw	1596	7	of	of	IN
cord-001835-0s7ok4uw	1596	8	life	life	NN
cord-001835-0s7ok4uw	1596	9	studies	study	NNS
cord-001835-0s7ok4uw	1596	10	,	,	,
cord-001835-0s7ok4uw	1596	11	a	a	DT
cord-001835-0s7ok4uw	1596	12	consensus	consensus	NN
cord-001835-0s7ok4uw	1596	13	on	on	IN
cord-001835-0s7ok4uw	1596	14	which	which	WDT
cord-001835-0s7ok4uw	1596	15	amino	amino	JJ
cord-001835-0s7ok4uw	1596	16	acids	acid	NNS
cord-001835-0s7ok4uw	1596	17	likely	likely	RB
cord-001835-0s7ok4uw	1596	18	populated	populated	JJ
cord-001835-0s7ok4uw	1596	19	early	early	JJ
cord-001835-0s7ok4uw	1596	20	earth	earth	NN
cord-001835-0s7ok4uw	1596	21	has	have	VBZ
cord-001835-0s7ok4uw	1596	22	emerged	emerge	VBN
cord-001835-0s7ok4uw	1596	23	.	.	.
cord-001835-0s7ok4uw	1597	1	These	these	DT
cord-001835-0s7ok4uw	1597	2	residues	residue	NNS
cord-001835-0s7ok4uw	1597	3	were	be	VBD
cord-001835-0s7ok4uw	1597	4	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	1597	5	by	by	IN
cord-001835-0s7ok4uw	1597	6	abiotic	abiotic	JJ
cord-001835-0s7ok4uw	1597	7	chemical	chemical	NN
cord-001835-0s7ok4uw	1597	8	and	and	CC
cord-001835-0s7ok4uw	1597	9	physical	physical	JJ
cord-001835-0s7ok4uw	1597	10	processes	process	NNS
cord-001835-0s7ok4uw	1597	11	from	from	IN
cord-001835-0s7ok4uw	1597	12	molecules	molecule	NNS
cord-001835-0s7ok4uw	1597	13	present	present	JJ
cord-001835-0s7ok4uw	1597	14	in	in	IN
cord-001835-0s7ok4uw	1597	15	the	the	DT
cord-001835-0s7ok4uw	1597	16	surrounding	surround	VBG
cord-001835-0s7ok4uw	1597	17	environment	environment	NN
cord-001835-0s7ok4uw	1597	18	.	.	.
cord-001835-0s7ok4uw	1598	1	The	the	DT
cord-001835-0s7ok4uw	1598	2	properties	property	NNS
cord-001835-0s7ok4uw	1598	3	of	of	IN
cord-001835-0s7ok4uw	1598	4	the	the	DT
cord-001835-0s7ok4uw	1598	5	consensus	consensus	NN
cord-001835-0s7ok4uw	1598	6	set	set	VBN
cord-001835-0s7ok4uw	1598	7	of	of	IN
cord-001835-0s7ok4uw	1598	8	common	common	JJ
cord-001835-0s7ok4uw	1598	9	prebiotic	prebiotic	JJ
cord-001835-0s7ok4uw	1598	10	amino	amino	NN
cord-001835-0s7ok4uw	1598	11	acids	acid	NNS
cord-001835-0s7ok4uw	1598	12	(	(	-LRB-
cord-001835-0s7ok4uw	1598	13	A	A	NNP
cord-001835-0s7ok4uw	1598	14	,	,	,
cord-001835-0s7ok4uw	1598	15	D	D	NNP
cord-001835-0s7ok4uw	1598	16	,	,	,
cord-001835-0s7ok4uw	1598	17	E	E	NNP
cord-001835-0s7ok4uw	1598	18	,	,	,
cord-001835-0s7ok4uw	1598	19	G	G	NNP
cord-001835-0s7ok4uw	1598	20	,	,	,
cord-001835-0s7ok4uw	1598	21	I	-PRON-	PRP
cord-001835-0s7ok4uw	1598	22	,	,	,
cord-001835-0s7ok4uw	1598	23	L	L	NNP
cord-001835-0s7ok4uw	1598	24	,	,	,
cord-001835-0s7ok4uw	1598	25	P	P	NNP
cord-001835-0s7ok4uw	1598	26	,	,	,
cord-001835-0s7ok4uw	1598	27	S	S	NNP
cord-001835-0s7ok4uw	1598	28	,	,	,
cord-001835-0s7ok4uw	1598	29	T	T	NNP
cord-001835-0s7ok4uw	1598	30	,	,	,
cord-001835-0s7ok4uw	1598	31	V	v	NN
cord-001835-0s7ok4uw	1598	32	)	)	-RRB-
cord-001835-0s7ok4uw	1598	33	are	be	VBP
cord-001835-0s7ok4uw	1598	34	compatible	compatible	JJ
cord-001835-0s7ok4uw	1598	35	with	with	IN
cord-001835-0s7ok4uw	1598	36	known	know	VBN
cord-001835-0s7ok4uw	1598	37	features	feature	NNS
cord-001835-0s7ok4uw	1598	38	of	of	IN
cord-001835-0s7ok4uw	1598	39	halophile	halophile	NNP
cord-001835-0s7ok4uw	1598	40	proteins	protein	NNS
cord-001835-0s7ok4uw	1598	41	,	,	,
cord-001835-0s7ok4uw	1598	42	meaning	mean	VBG
cord-001835-0s7ok4uw	1598	43	these	these	DT
cord-001835-0s7ok4uw	1598	44	proteins	protein	NNS
cord-001835-0s7ok4uw	1598	45	are	be	VBP
cord-001835-0s7ok4uw	1598	46	only	only	RB
cord-001835-0s7ok4uw	1598	47	stable	stable	JJ
cord-001835-0s7ok4uw	1598	48	in	in	IN
cord-001835-0s7ok4uw	1598	49	the	the	DT
cord-001835-0s7ok4uw	1598	50	presence	presence	NN
cord-001835-0s7ok4uw	1598	51	of	of	IN
cord-001835-0s7ok4uw	1598	52	high	high	JJ
cord-001835-0s7ok4uw	1598	53	salt	salt	NN
cord-001835-0s7ok4uw	1598	54	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1598	55	.	.	.
cord-001835-0s7ok4uw	1599	1	The	the	DT
cord-001835-0s7ok4uw	1599	2	halophile	halophile	NNP
cord-001835-0s7ok4uw	1599	3	environment	environment	NN
cord-001835-0s7ok4uw	1599	4	,	,	,
cord-001835-0s7ok4uw	1599	5	thus	thus	RB
cord-001835-0s7ok4uw	1599	6	,	,	,
cord-001835-0s7ok4uw	1599	7	has	have	VBZ
cord-001835-0s7ok4uw	1599	8	a	a	DT
cord-001835-0s7ok4uw	1599	9	number	number	NN
cord-001835-0s7ok4uw	1599	10	of	of	IN
cord-001835-0s7ok4uw	1599	11	compelling	compelling	JJ
cord-001835-0s7ok4uw	1599	12	aspects	aspect	NNS
cord-001835-0s7ok4uw	1599	13	with	with	IN
cord-001835-0s7ok4uw	1599	14	regard	regard	NN
cord-001835-0s7ok4uw	1599	15	to	to	IN
cord-001835-0s7ok4uw	1599	16	the	the	DT
cord-001835-0s7ok4uw	1599	17	origin	origin	NN
cord-001835-0s7ok4uw	1599	18	of	of	IN
cord-001835-0s7ok4uw	1599	19	structured	structured	JJ
cord-001835-0s7ok4uw	1599	20	polypeptides	polypeptide	NNS
cord-001835-0s7ok4uw	1599	21	.	.	.
cord-001835-0s7ok4uw	1600	1	Consequently	consequently	RB
cord-001835-0s7ok4uw	1600	2	,	,	,
cord-001835-0s7ok4uw	1600	3	a	a	DT
cord-001835-0s7ok4uw	1600	4	proposed	propose	VBN
cord-001835-0s7ok4uw	1600	5	key	key	JJ
cord-001835-0s7ok4uw	1600	6	step	step	NN
cord-001835-0s7ok4uw	1600	7	in	in	IN
cord-001835-0s7ok4uw	1600	8	evolution	evolution	NN
cord-001835-0s7ok4uw	1600	9	was	be	VBD
cord-001835-0s7ok4uw	1600	10	,	,	,
cord-001835-0s7ok4uw	1600	11	movement	movement	NN
cord-001835-0s7ok4uw	1600	12	out	out	IN
cord-001835-0s7ok4uw	1600	13	of	of	IN
cord-001835-0s7ok4uw	1600	14	the	the	DT
cord-001835-0s7ok4uw	1600	15	halophile	halophile	NNP
cord-001835-0s7ok4uw	1600	16	regime	regime	NN
cord-001835-0s7ok4uw	1600	17	into	into	IN
cord-001835-0s7ok4uw	1600	18	a	a	DT
cord-001835-0s7ok4uw	1600	19	mesophile	mesophile	JJ
cord-001835-0s7ok4uw	1600	20	one	one	CD
cord-001835-0s7ok4uw	1600	21	commensurate	commensurate	NN
cord-001835-0s7ok4uw	1600	22	with	with	IN
cord-001835-0s7ok4uw	1600	23	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	1600	24	of	of	IN
cord-001835-0s7ok4uw	1600	25	"	"	``
cord-001835-0s7ok4uw	1600	26	phase	phase	NN
cord-001835-0s7ok4uw	1600	27	2	2	CD
cord-001835-0s7ok4uw	1600	28	"	"	''
cord-001835-0s7ok4uw	1600	29	amino	amino	JJ
cord-001835-0s7ok4uw	1600	30	acids	acid	NNS
cord-001835-0s7ok4uw	1601	1	-including	-include	VBG
cord-001835-0s7ok4uw	1602	1	the	the	DT
cord-001835-0s7ok4uw	1602	2	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	1602	3	and	and	CC
cord-001835-0s7ok4uw	1602	4	basic	basic	JJ
cord-001835-0s7ok4uw	1602	5	amino	amino	NN
cord-001835-0s7ok4uw	1602	6	acids	acid	NNS
cord-001835-0s7ok4uw	1602	7	.	.	.
cord-001835-0s7ok4uw	1603	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1603	2	tested	test	VBD
cord-001835-0s7ok4uw	1603	3	the	the	DT
cord-001835-0s7ok4uw	1603	4	effects	effect	NNS
cord-001835-0s7ok4uw	1603	5	of	of	IN
cord-001835-0s7ok4uw	1603	6	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	1603	7	residue	residue	NN
cord-001835-0s7ok4uw	1603	8	addition	addition	NN
cord-001835-0s7ok4uw	1603	9	to	to	IN
cord-001835-0s7ok4uw	1603	10	the	the	DT
cord-001835-0s7ok4uw	1603	11	core	core	NN
cord-001835-0s7ok4uw	1603	12	of	of	IN
cord-001835-0s7ok4uw	1603	13	a	a	DT
cord-001835-0s7ok4uw	1603	14	"	"	``
cord-001835-0s7ok4uw	1603	15	primitive	primitive	JJ
cord-001835-0s7ok4uw	1603	16	"	"	''
cord-001835-0s7ok4uw	1603	17	designed	design	VBN
cord-001835-0s7ok4uw	1603	18	protein	protein	NN
cord-001835-0s7ok4uw	1603	19	enriched	enrich	VBN
cord-001835-0s7ok4uw	1603	20	for	for	IN
cord-001835-0s7ok4uw	1603	21	the	the	DT
cord-001835-0s7ok4uw	1603	22	prebiotic	prebiotic	JJ
cord-001835-0s7ok4uw	1603	23	amino	amino	NN
cord-001835-0s7ok4uw	1603	24	acids	acid	NNS
cord-001835-0s7ok4uw	1603	25	(	(	-LRB-
cord-001835-0s7ok4uw	1603	26	A	A	NNP
cord-001835-0s7ok4uw	1603	27	,	,	,
cord-001835-0s7ok4uw	1603	28	D	D	NNP
cord-001835-0s7ok4uw	1603	29	,	,	,
cord-001835-0s7ok4uw	1603	30	E	E	NNP
cord-001835-0s7ok4uw	1603	31	,	,	,
cord-001835-0s7ok4uw	1603	32	G	G	NNP
cord-001835-0s7ok4uw	1603	33	,	,	,
cord-001835-0s7ok4uw	1603	34	I	-PRON-	PRP
cord-001835-0s7ok4uw	1603	35	,	,	,
cord-001835-0s7ok4uw	1603	36	L	L	NNP
cord-001835-0s7ok4uw	1603	37	,	,	,
cord-001835-0s7ok4uw	1603	38	P	P	NNP
cord-001835-0s7ok4uw	1603	39	,	,	,
cord-001835-0s7ok4uw	1603	40	S	S	NNP
cord-001835-0s7ok4uw	1603	41	,	,	,
cord-001835-0s7ok4uw	1603	42	T	T	NNP
cord-001835-0s7ok4uw	1603	43	,	,	,
cord-001835-0s7ok4uw	1603	44	V	v	NN
cord-001835-0s7ok4uw	1603	45	)	)	-RRB-
cord-001835-0s7ok4uw	1603	46	that	that	WDT
cord-001835-0s7ok4uw	1603	47	required	require	VBD
cord-001835-0s7ok4uw	1603	48	halophilic	halophilic	NNP
cord-001835-0s7ok4uw	1603	49	conditions	condition	NNS
cord-001835-0s7ok4uw	1603	50	for	for	IN
cord-001835-0s7ok4uw	1603	51	folding	folding	NN
cord-001835-0s7ok4uw	1603	52	.	.	.
cord-001835-0s7ok4uw	1604	1	The	the	DT
cord-001835-0s7ok4uw	1604	2	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	1604	3	results	result	NNS
cord-001835-0s7ok4uw	1604	4	show	show	VBP
cord-001835-0s7ok4uw	1604	5	that	that	IN
cord-001835-0s7ok4uw	1604	6	the	the	DT
cord-001835-0s7ok4uw	1604	7	inclusion	inclusion	NN
cord-001835-0s7ok4uw	1604	8	of	of	IN
cord-001835-0s7ok4uw	1604	9	just	just	RB
cord-001835-0s7ok4uw	1604	10	a	a	DT
cord-001835-0s7ok4uw	1604	11	single	single	JJ
cord-001835-0s7ok4uw	1604	12	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	1604	13	residue	residue	NN
cord-001835-0s7ok4uw	1604	14	was	be	VBD
cord-001835-0s7ok4uw	1604	15	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	1604	16	for	for	IN
cord-001835-0s7ok4uw	1604	17	movement	movement	NN
cord-001835-0s7ok4uw	1604	18	to	to	IN
cord-001835-0s7ok4uw	1604	19	a	a	DT
cord-001835-0s7ok4uw	1604	20	mesophile	mesophile	NN
cord-001835-0s7ok4uw	1604	21	folding	folding	NN
cord-001835-0s7ok4uw	1604	22	environment	environment	NN
cord-001835-0s7ok4uw	1604	23	.	.	.
cord-001835-0s7ok4uw	1605	1	Thus	thus	RB
cord-001835-0s7ok4uw	1605	2	,	,	,
cord-001835-0s7ok4uw	1605	3	the	the	DT
cord-001835-0s7ok4uw	1605	4	inclusion	inclusion	NN
cord-001835-0s7ok4uw	1605	5	of	of	IN
cord-001835-0s7ok4uw	1605	6	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	1605	7	residues	residue	NNS
cord-001835-0s7ok4uw	1605	8	into	into	IN
cord-001835-0s7ok4uw	1605	9	the	the	DT
cord-001835-0s7ok4uw	1605	10	codon	codon	NN
cord-001835-0s7ok4uw	1605	11	table	table	NN
cord-001835-0s7ok4uw	1605	12	could	could	MD
cord-001835-0s7ok4uw	1605	13	have	have	VB
cord-001835-0s7ok4uw	1605	14	conferred	confer	VBN
cord-001835-0s7ok4uw	1605	15	key	key	JJ
cord-001835-0s7ok4uw	1605	16	stability	stability	NN
cord-001835-0s7ok4uw	1605	17	to	to	IN
cord-001835-0s7ok4uw	1605	18	early	early	JJ
cord-001835-0s7ok4uw	1605	19	proteins	protein	NNS
cord-001835-0s7ok4uw	1605	20	enabling	enable	VBG
cord-001835-0s7ok4uw	1605	21	adaptive	adaptive	JJ
cord-001835-0s7ok4uw	1605	22	radiation	radiation	NN
cord-001835-0s7ok4uw	1605	23	outside	outside	IN
cord-001835-0s7ok4uw	1605	24	of	of	IN
cord-001835-0s7ok4uw	1605	25	a	a	DT
cord-001835-0s7ok4uw	1605	26	halophile	halophile	JJ
cord-001835-0s7ok4uw	1605	27	environment	environment	NN
cord-001835-0s7ok4uw	1605	28	.	.	.
cord-001835-0s7ok4uw	1606	1	Contact	contact	NN
cord-001835-0s7ok4uw	1606	2	prediction	prediction	NN
cord-001835-0s7ok4uw	1606	3	methods	method	NNS
cord-001835-0s7ok4uw	1606	4	that	that	WDT
cord-001835-0s7ok4uw	1606	5	rely	rely	VBP
cord-001835-0s7ok4uw	1606	6	on	on	IN
cord-001835-0s7ok4uw	1606	7	sequence	sequence	NN
cord-001835-0s7ok4uw	1606	8	information	information	NN
cord-001835-0s7ok4uw	1606	9	alone	alone	RB
cord-001835-0s7ok4uw	1606	10	,	,	,
cord-001835-0s7ok4uw	1606	11	such	such	JJ
cord-001835-0s7ok4uw	1606	12	as	as	IN
cord-001835-0s7ok4uw	1606	13	EVfold	EVfold	NNP
cord-001835-0s7ok4uw	1606	14	,	,	,
cord-001835-0s7ok4uw	1606	15	can	can	MD
cord-001835-0s7ok4uw	1606	16	be	be	VB
cord-001835-0s7ok4uw	1606	17	used	use	VBN
cord-001835-0s7ok4uw	1606	18	for	for	IN
cord-001835-0s7ok4uw	1606	19	de	de	NNP
cord-001835-0s7ok4uw	1606	20	novo	novo	NNP
cord-001835-0s7ok4uw	1606	21	3D	3D	NNP
cord-001835-0s7ok4uw	1606	22	structure	structure	NNP
cord-001835-0s7ok4uw	1606	23	prediction	prediction	NN
cord-001835-0s7ok4uw	1606	24	and	and	CC
cord-001835-0s7ok4uw	1606	25	identification	identification	NN
cord-001835-0s7ok4uw	1606	26	of	of	IN
cord-001835-0s7ok4uw	1606	27	functionally	functionally	RB
cord-001835-0s7ok4uw	1606	28	important	important	JJ
cord-001835-0s7ok4uw	1606	29	residues	residue	NNS
cord-001835-0s7ok4uw	1606	30	in	in	IN
cord-001835-0s7ok4uw	1606	31	proteins	protein	NNS
cord-001835-0s7ok4uw	1606	32	.	.	.
cord-001835-0s7ok4uw	1607	1	Large	large	JJ
cord-001835-0s7ok4uw	1607	2	multiple	multiple	JJ
cord-001835-0s7ok4uw	1607	3	sequence	sequence	NN
cord-001835-0s7ok4uw	1607	4	alignments	alignment	NNS
cord-001835-0s7ok4uw	1607	5	of	of	IN
cord-001835-0s7ok4uw	1607	6	protein	protein	NN
cord-001835-0s7ok4uw	1607	7	families	family	NNS
cord-001835-0s7ok4uw	1607	8	consisting	consist	VBG
cord-001835-0s7ok4uw	1607	9	of	of	IN
cord-001835-0s7ok4uw	1607	10	evolutionarily	evolutionarily	RB
cord-001835-0s7ok4uw	1607	11	related	related	JJ
cord-001835-0s7ok4uw	1607	12	and	and	CC
cord-001835-0s7ok4uw	1607	13	plausibly	plausibly	RB
cord-001835-0s7ok4uw	1607	14	isostructural	isostructural	JJ
cord-001835-0s7ok4uw	1607	15	members	member	NNS
cord-001835-0s7ok4uw	1607	16	reveal	reveal	VBP
cord-001835-0s7ok4uw	1607	17	co	co	NN
cord-001835-0s7ok4uw	1607	18	-	-	JJ
cord-001835-0s7ok4uw	1607	19	variation	variation	JJ
cord-001835-0s7ok4uw	1607	20	patterns	pattern	NNS
cord-001835-0s7ok4uw	1607	21	that	that	WDT
cord-001835-0s7ok4uw	1607	22	can	can	MD
cord-001835-0s7ok4uw	1607	23	be	be	VB
cord-001835-0s7ok4uw	1607	24	used	use	VBN
cord-001835-0s7ok4uw	1607	25	to	to	TO
cord-001835-0s7ok4uw	1607	26	identify	identify	VB
cord-001835-0s7ok4uw	1607	27	interactions	interaction	NNS
cord-001835-0s7ok4uw	1607	28	between	between	IN
cord-001835-0s7ok4uw	1607	29	pairs	pair	NNS
cord-001835-0s7ok4uw	1607	30	of	of	IN
cord-001835-0s7ok4uw	1607	31	amino	amino	JJ
cord-001835-0s7ok4uw	1607	32	acids	acid	NNS
cord-001835-0s7ok4uw	1607	33	.	.	.
cord-001835-0s7ok4uw	1608	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1608	2	use	use	VBP
cord-001835-0s7ok4uw	1608	3	a	a	DT
cord-001835-0s7ok4uw	1608	4	global	global	JJ
cord-001835-0s7ok4uw	1608	5	probability	probability	NN
cord-001835-0s7ok4uw	1608	6	model	model	NN
cord-001835-0s7ok4uw	1608	7	to	to	TO
cord-001835-0s7ok4uw	1608	8	disambiguate	disambiguate	VB
cord-001835-0s7ok4uw	1608	9	direct	direct	JJ
cord-001835-0s7ok4uw	1608	10	and	and	CC
cord-001835-0s7ok4uw	1608	11	indirect	indirect	JJ
cord-001835-0s7ok4uw	1608	12	correlations	correlation	NNS
cord-001835-0s7ok4uw	1608	13	.	.	.
cord-001835-0s7ok4uw	1609	1	Specifically	specifically	RB
cord-001835-0s7ok4uw	1609	2	,	,	,
cord-001835-0s7ok4uw	1609	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1609	4	use	use	VBP
cord-001835-0s7ok4uw	1609	5	a	a	DT
cord-001835-0s7ok4uw	1609	6	maximum	maximum	JJ
cord-001835-0s7ok4uw	1609	7	entropy	entropy	NN
cord-001835-0s7ok4uw	1609	8	approach	approach	NN
cord-001835-0s7ok4uw	1609	9	called	call	VBN
cord-001835-0s7ok4uw	1609	10	pseudo	pseudo	JJ
cord-001835-0s7ok4uw	1609	11	-	-	JJ
cord-001835-0s7ok4uw	1609	12	likelihood	likelihood	JJ
cord-001835-0s7ok4uw	1609	13	maximization	maximization	NN
cord-001835-0s7ok4uw	1609	14	(	(	-LRB-
cord-001835-0s7ok4uw	1609	15	PLM	PLM	NNP
cord-001835-0s7ok4uw	1609	16	)	)	-RRB-
cord-001835-0s7ok4uw	1609	17	to	to	TO
cord-001835-0s7ok4uw	1609	18	distinguish	distinguish	VB
cord-001835-0s7ok4uw	1609	19	causation	causation	NN
cord-001835-0s7ok4uw	1609	20	(	(	-LRB-
cord-001835-0s7ok4uw	1609	21	residue	residue	NN
cord-001835-0s7ok4uw	1609	22	interactions	interaction	NNS
cord-001835-0s7ok4uw	1609	23	)	)	-RRB-
cord-001835-0s7ok4uw	1609	24	from	from	IN
cord-001835-0s7ok4uw	1609	25	correlation	correlation	NN
cord-001835-0s7ok4uw	1609	26	(	(	-LRB-
cord-001835-0s7ok4uw	1609	27	correlated	correlate	VBN
cord-001835-0s7ok4uw	1609	28	mutations	mutation	NNS
cord-001835-0s7ok4uw	1609	29	)	)	-RRB-
cord-001835-0s7ok4uw	1609	30	and	and	CC
cord-001835-0s7ok4uw	1609	31	compute	compute	VB
cord-001835-0s7ok4uw	1609	32	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	1609	33	couplings	coupling	NNS
cord-001835-0s7ok4uw	1609	34	(	(	-LRB-
cord-001835-0s7ok4uw	1609	35	ECs	ECs	NNP
cord-001835-0s7ok4uw	1609	36	)	)	-RRB-
cord-001835-0s7ok4uw	1609	37	.	.	.
cord-001835-0s7ok4uw	1610	1	The	the	DT
cord-001835-0s7ok4uw	1610	2	inferred	infer	VBN
cord-001835-0s7ok4uw	1610	3	set	set	NN
cord-001835-0s7ok4uw	1610	4	of	of	IN
cord-001835-0s7ok4uw	1610	5	residue	residue	NN
cord-001835-0s7ok4uw	1610	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	1610	7	can	can	MD
cord-001835-0s7ok4uw	1610	8	then	then	RB
cord-001835-0s7ok4uw	1610	9	be	be	VB
cord-001835-0s7ok4uw	1610	10	interpreted	interpret	VBN
cord-001835-0s7ok4uw	1610	11	as	as	IN
cord-001835-0s7ok4uw	1610	12	physical	physical	JJ
cord-001835-0s7ok4uw	1610	13	contacts	contact	NNS
cord-001835-0s7ok4uw	1610	14	and	and	CC
cord-001835-0s7ok4uw	1610	15	used	use	VBN
cord-001835-0s7ok4uw	1610	16	in	in	IN
cord-001835-0s7ok4uw	1610	17	de	de	NNP
cord-001835-0s7ok4uw	1610	18	novo	novo	NNP
cord-001835-0s7ok4uw	1610	19	3D	3D	NNP
cord-001835-0s7ok4uw	1610	20	structure	structure	NNP
cord-001835-0s7ok4uw	1610	21	prediction	prediction	NN
cord-001835-0s7ok4uw	1610	22	.	.	.
cord-001835-0s7ok4uw	1611	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1611	2	,	,	,
cord-001835-0s7ok4uw	1611	3	the	the	DT
cord-001835-0s7ok4uw	1611	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	1611	5	that	that	WDT
cord-001835-0s7ok4uw	1611	6	are	be	VBP
cord-001835-0s7ok4uw	1611	7	inferred	infer	VBN
cord-001835-0s7ok4uw	1611	8	can	can	MD
cord-001835-0s7ok4uw	1611	9	help	help	VB
cord-001835-0s7ok4uw	1611	10	guide	guide	VB
cord-001835-0s7ok4uw	1611	11	experiments	experiment	NNS
cord-001835-0s7ok4uw	1611	12	that	that	WDT
cord-001835-0s7ok4uw	1611	13	measure	measure	VBP
cord-001835-0s7ok4uw	1611	14	the	the	DT
cord-001835-0s7ok4uw	1611	15	phenotypic	phenotypic	JJ
cord-001835-0s7ok4uw	1611	16	consequences	consequence	NNS
cord-001835-0s7ok4uw	1611	17	of	of	IN
cord-001835-0s7ok4uw	1611	18	protein	protein	NN
cord-001835-0s7ok4uw	1611	19	substitutions	substitution	NNS
cord-001835-0s7ok4uw	1611	20	,	,	,
cord-001835-0s7ok4uw	1611	21	making	make	VBG
cord-001835-0s7ok4uw	1611	22	the	the	DT
cord-001835-0s7ok4uw	1611	23	method	method	NN
cord-001835-0s7ok4uw	1611	24	useful	useful	JJ
cord-001835-0s7ok4uw	1611	25	for	for	IN
cord-001835-0s7ok4uw	1611	26	functional	functional	JJ
cord-001835-0s7ok4uw	1611	27	studies	study	NNS
cord-001835-0s7ok4uw	1611	28	.	.	.
cord-001835-0s7ok4uw	1612	1	The	the	DT
cord-001835-0s7ok4uw	1612	2	present	present	JJ
cord-001835-0s7ok4uw	1612	3	work	work	NN
cord-001835-0s7ok4uw	1612	4	can	can	MD
cord-001835-0s7ok4uw	1612	5	be	be	VB
cord-001835-0s7ok4uw	1612	6	divided	divide	VBN
cord-001835-0s7ok4uw	1612	7	into	into	IN
cord-001835-0s7ok4uw	1612	8	three	three	CD
cord-001835-0s7ok4uw	1612	9	areas	area	NNS
cord-001835-0s7ok4uw	1612	10	:	:	:
cord-001835-0s7ok4uw	1612	11	(	(	-LRB-
cord-001835-0s7ok4uw	1612	12	i	i	NN
cord-001835-0s7ok4uw	1612	13	)	)	-RRB-
cord-001835-0s7ok4uw	1612	14	methodological	methodological	JJ
cord-001835-0s7ok4uw	1612	15	improvements	improvement	NNS
cord-001835-0s7ok4uw	1612	16	related	relate	VBN
cord-001835-0s7ok4uw	1612	17	to	to	IN
cord-001835-0s7ok4uw	1612	18	alignment	alignment	NN
cord-001835-0s7ok4uw	1612	19	,	,	,
cord-001835-0s7ok4uw	1612	20	folding	fold	VBG
cord-001835-0s7ok4uw	1612	21	procedure	procedure	NN
cord-001835-0s7ok4uw	1612	22	,	,	,
cord-001835-0s7ok4uw	1612	23	structure	structure	NN
cord-001835-0s7ok4uw	1612	24	refinement	refinement	NN
cord-001835-0s7ok4uw	1612	25	and	and	CC
cord-001835-0s7ok4uw	1612	26	ranking	ranking	NN
cord-001835-0s7ok4uw	1612	27	;	;	:
cord-001835-0s7ok4uw	1612	28	(	(	-LRB-
cord-001835-0s7ok4uw	1612	29	ii	ii	NN
cord-001835-0s7ok4uw	1612	30	)	)	-RRB-
cord-001835-0s7ok4uw	1612	31	folding	folding	NN
cord-001835-0s7ok4uw	1612	32	of	of	IN
cord-001835-0s7ok4uw	1612	33	proteins	protein	NNS
cord-001835-0s7ok4uw	1612	34	of	of	IN
cord-001835-0s7ok4uw	1612	35	known	know	VBN
cord-001835-0s7ok4uw	1612	36	structure	structure	NN
cord-001835-0s7ok4uw	1612	37	for	for	IN
cord-001835-0s7ok4uw	1612	38	benchmarking	benchmarking	NN
cord-001835-0s7ok4uw	1612	39	and	and	CC
cord-001835-0s7ok4uw	1612	40	prediction	prediction	NN
cord-001835-0s7ok4uw	1612	41	of	of	IN
cord-001835-0s7ok4uw	1612	42	proteins	protein	NNS
cord-001835-0s7ok4uw	1612	43	of	of	IN
cord-001835-0s7ok4uw	1612	44	unknown	unknown	JJ
cord-001835-0s7ok4uw	1612	45	structure	structure	NN
cord-001835-0s7ok4uw	1612	46	;	;	,
cord-001835-0s7ok4uw	1612	47	and	and	CC
cord-001835-0s7ok4uw	1612	48	(	(	-LRB-
cord-001835-0s7ok4uw	1612	49	iii	iii	NN
cord-001835-0s7ok4uw	1612	50	)	)	-RRB-
cord-001835-0s7ok4uw	1612	51	focused	focus	VBN
cord-001835-0s7ok4uw	1612	52	exploration	exploration	NN
cord-001835-0s7ok4uw	1612	53	of	of	IN
cord-001835-0s7ok4uw	1612	54	specific	specific	JJ
cord-001835-0s7ok4uw	1612	55	cases	case	NNS
cord-001835-0s7ok4uw	1612	56	of	of	IN
cord-001835-0s7ok4uw	1612	57	interest	interest	NN
cord-001835-0s7ok4uw	1612	58	.	.	.
cord-001835-0s7ok4uw	1613	1	Developing	develop	VBG
cord-001835-0s7ok4uw	1613	2	SHuffle	SHuffle	NNP
cord-001835-0s7ok4uw	1613	3	as	as	IN
cord-001835-0s7ok4uw	1613	4	a	a	DT
cord-001835-0s7ok4uw	1613	5	platform	platform	NN
cord-001835-0s7ok4uw	1613	6	for	for	IN
cord-001835-0s7ok4uw	1613	7	expression	expression	NN
cord-001835-0s7ok4uw	1613	8	and	and	CC
cord-001835-0s7ok4uw	1613	9	engineering	engineering	NN
cord-001835-0s7ok4uw	1613	10	of	of	IN
cord-001835-0s7ok4uw	1613	11	antibodies	antibody	NNS
cord-001835-0s7ok4uw	1613	12	Na	Na	NNP
cord-001835-0s7ok4uw	1613	13	Ke	Ke	NNP
cord-001835-0s7ok4uw	1613	14	1	1	CD
cord-001835-0s7ok4uw	1613	15	,	,	,
cord-001835-0s7ok4uw	1613	16	Alana	Alana	NNP
cord-001835-0s7ok4uw	1613	17	Ali	Ali	NNP
cord-001835-0s7ok4uw	1613	18	-	-	HYPH
cord-001835-0s7ok4uw	1613	19	Reynolds	Reynolds	NNP
cord-001835-0s7ok4uw	1613	20	1	1	CD
cord-001835-0s7ok4uw	1613	21	,	,	,
cord-001835-0s7ok4uw	1613	22	Bryce	Bryce	NNP
cord-001835-0s7ok4uw	1613	23	Causey	Causey	NNP
cord-001835-0s7ok4uw	1613	24	1	1	CD
cord-001835-0s7ok4uw	1613	25	,	,	,
cord-001835-0s7ok4uw	1613	26	Berkmen	Berkmen	NNP
cord-001835-0s7ok4uw	1613	27	Berkmen	Berkmen	NNP
cord-001835-0s7ok4uw	1614	1	1	1	CD
cord-001835-0s7ok4uw	1614	2	1	1	CD
cord-001835-0s7ok4uw	1614	3	SHuffle	SHuffle	NNP
cord-001835-0s7ok4uw	1614	4	is	be	VBZ
cord-001835-0s7ok4uw	1614	5	a	a	DT
cord-001835-0s7ok4uw	1614	6	genetically	genetically	RB
cord-001835-0s7ok4uw	1614	7	engineered	engineer	VBN
cord-001835-0s7ok4uw	1614	8	E.coli	e.coli	NN
cord-001835-0s7ok4uw	1614	9	strain	strain	NN
cord-001835-0s7ok4uw	1614	10	that	that	WDT
cord-001835-0s7ok4uw	1614	11	allows	allow	VBZ
cord-001835-0s7ok4uw	1614	12	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	1614	13	bond	bond	NN
cord-001835-0s7ok4uw	1614	14	formationin	formationin	NNP
cord-001835-0s7ok4uw	1614	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1614	16	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	1614	17	with	with	IN
cord-001835-0s7ok4uw	1614	18	high	high	JJ
cord-001835-0s7ok4uw	1614	19	fidelity	fidelity	NN
cord-001835-0s7ok4uw	1614	20	.	.	.
cord-001835-0s7ok4uw	1615	1	Many	many	JJ
cord-001835-0s7ok4uw	1615	2	proteins	protein	NNS
cord-001835-0s7ok4uw	1615	3	containing	contain	VBG
cord-001835-0s7ok4uw	1615	4	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	1615	5	bonds	bond	NNS
cord-001835-0s7ok4uw	1615	6	have	have	VBP
cord-001835-0s7ok4uw	1615	7	been	be	VBN
cord-001835-0s7ok4uw	1615	8	successfully	successfully	RB
cord-001835-0s7ok4uw	1615	9	expressed	express	VBN
cord-001835-0s7ok4uw	1615	10	in	in	IN
cord-001835-0s7ok4uw	1615	11	SHuffle	SHuffle	NNP
cord-001835-0s7ok4uw	1615	12	.	.	.
cord-001835-0s7ok4uw	1616	1	In	in	IN
cord-001835-0s7ok4uw	1616	2	this	this	DT
cord-001835-0s7ok4uw	1616	3	study	study	NN
cord-001835-0s7ok4uw	1616	4	,	,	,
cord-001835-0s7ok4uw	1616	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1616	6	expressed	express	VBD
cord-001835-0s7ok4uw	1616	7	,	,	,
cord-001835-0s7ok4uw	1616	8	purified	purify	VBN
cord-001835-0s7ok4uw	1616	9	and	and	CC
cord-001835-0s7ok4uw	1616	10	characterized	characterize	VBN
cord-001835-0s7ok4uw	1616	11	full	full	JJ
cord-001835-0s7ok4uw	1616	12	-	-	HYPH
cord-001835-0s7ok4uw	1616	13	length	length	NN
cord-001835-0s7ok4uw	1616	14	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	1616	15	antibody	antibody	NN
cord-001835-0s7ok4uw	1616	16	IgG	igg	NN
cord-001835-0s7ok4uw	1616	17	in	in	IN
cord-001835-0s7ok4uw	1616	18	SHuffle	SHuffle	NNP
cord-001835-0s7ok4uw	1616	19	.	.	.
cord-001835-0s7ok4uw	1617	1	For	for	IN
cord-001835-0s7ok4uw	1617	2	the	the	DT
cord-001835-0s7ok4uw	1617	3	first	first	JJ
cord-001835-0s7ok4uw	1617	4	time	time	NN
cord-001835-0s7ok4uw	1617	5	,	,	,
cord-001835-0s7ok4uw	1617	6	a	a	DT
cord-001835-0s7ok4uw	1617	7	fulllength	fulllength	NN
cord-001835-0s7ok4uw	1617	8	IgG	igg	NN
cord-001835-0s7ok4uw	1617	9	can	can	MD
cord-001835-0s7ok4uw	1617	10	be	be	VB
cord-001835-0s7ok4uw	1617	11	functionally	functionally	RB
cord-001835-0s7ok4uw	1617	12	expressed	express	VBN
cord-001835-0s7ok4uw	1617	13	in	in	IN
cord-001835-0s7ok4uw	1617	14	the	the	DT
cord-001835-0s7ok4uw	1617	15	cytoplasm	cytoplasm	JJ
cord-001835-0s7ok4uw	1617	16	compartment	compartment	NN
cord-001835-0s7ok4uw	1617	17	of	of	IN
cord-001835-0s7ok4uw	1617	18	an	an	DT
cord-001835-0s7ok4uw	1617	19	E.coli	e.coli	NN
cord-001835-0s7ok4uw	1617	20	strain	strain	NN
cord-001835-0s7ok4uw	1617	21	.	.	.
cord-001835-0s7ok4uw	1618	1	In	in	IN
cord-001835-0s7ok4uw	1618	2	order	order	NN
cord-001835-0s7ok4uw	1618	3	to	to	TO
cord-001835-0s7ok4uw	1618	4	improve	improve	VB
cord-001835-0s7ok4uw	1618	5	the	the	DT
cord-001835-0s7ok4uw	1618	6	folding	folding	NN
cord-001835-0s7ok4uw	1618	7	and	and	CC
cord-001835-0s7ok4uw	1618	8	assembly	assembly	NN
cord-001835-0s7ok4uw	1618	9	of	of	IN
cord-001835-0s7ok4uw	1618	10	IgG	IgG	NNP
cord-001835-0s7ok4uw	1618	11	,	,	,
cord-001835-0s7ok4uw	1618	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	1618	13	have	have	VBP
cord-001835-0s7ok4uw	1618	14	investigated	investigate	VBN
cord-001835-0s7ok4uw	1618	15	the	the	DT
cord-001835-0s7ok4uw	1618	16	expression	expression	NN
cord-001835-0s7ok4uw	1618	17	of	of	IN
cord-001835-0s7ok4uw	1618	18	IgG	igg	NN
cord-001835-0s7ok4uw	1618	19	in	in	IN
cord-001835-0s7ok4uw	1618	20	various	various	JJ
cord-001835-0s7ok4uw	1618	21	formats	format	NNS
cord-001835-0s7ok4uw	1618	22	and	and	CC
cord-001835-0s7ok4uw	1618	23	vectors	vector	NNS
cord-001835-0s7ok4uw	1618	24	;	;	:
cord-001835-0s7ok4uw	1618	25	we	-PRON-	PRP
cord-001835-0s7ok4uw	1618	26	have	have	VBP
cord-001835-0s7ok4uw	1618	27	co	co	VBN
cord-001835-0s7ok4uw	1618	28	-	-	VBN
cord-001835-0s7ok4uw	1618	29	expressed	express	VBN
cord-001835-0s7ok4uw	1618	30	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	1618	31	and	and	CC
cord-001835-0s7ok4uw	1618	32	other	other	JJ
cord-001835-0s7ok4uw	1618	33	helper	helper	NN
cord-001835-0s7ok4uw	1618	34	proteins	protein	NNS
cord-001835-0s7ok4uw	1618	35	with	with	IN
cord-001835-0s7ok4uw	1618	36	IgG.	IgG.	NNP
cord-001835-0s7ok4uw	1618	37	Several	several	JJ
cord-001835-0s7ok4uw	1618	38	-	-	HYPH
cord-001835-0s7ok4uw	1618	39	fold	fold	JJ
cord-001835-0s7ok4uw	1618	40	increase	increase	NN
cord-001835-0s7ok4uw	1618	41	in	in	IN
cord-001835-0s7ok4uw	1618	42	the	the	DT
cord-001835-0s7ok4uw	1618	43	yield	yield	NN
cord-001835-0s7ok4uw	1618	44	of	of	IN
cord-001835-0s7ok4uw	1618	45	fulllength	fulllength	NN
cord-001835-0s7ok4uw	1618	46	IgG	IgG	NNP
cord-001835-0s7ok4uw	1618	47	was	be	VBD
cord-001835-0s7ok4uw	1618	48	observed	observe	VBN
cord-001835-0s7ok4uw	1618	49	.	.	.
cord-001835-0s7ok4uw	1619	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1619	2	characterized	characterize	VBD
cord-001835-0s7ok4uw	1619	3	the	the	DT
cord-001835-0s7ok4uw	1619	4	SHuffle	SHuffle	NNP
cord-001835-0s7ok4uw	1619	5	produced	produce	VBD
cord-001835-0s7ok4uw	1619	6	IgG	igg	NN
cord-001835-0s7ok4uw	1619	7	and	and	CC
cord-001835-0s7ok4uw	1619	8	found	find	VBD
cord-001835-0s7ok4uw	1619	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	1619	10	comparable	comparable	JJ
cord-001835-0s7ok4uw	1619	11	to	to	IN
cord-001835-0s7ok4uw	1619	12	hybridoma	hybridoma	NN
cord-001835-0s7ok4uw	1619	13	produced	produce	VBN
cord-001835-0s7ok4uw	1620	1	IgG.	IgG.	NNP
cord-001835-0s7ok4uw	1621	1	Optimization	optimization	NN
cord-001835-0s7ok4uw	1621	2	of	of	IN
cord-001835-0s7ok4uw	1621	3	fermentation	fermentation	NN
cord-001835-0s7ok4uw	1621	4	conditions	condition	NNS
cord-001835-0s7ok4uw	1621	5	for	for	IN
cord-001835-0s7ok4uw	1621	6	a	a	DT
cord-001835-0s7ok4uw	1621	7	large	large	JJ
cord-001835-0s7ok4uw	1621	8	-	-	HYPH
cord-001835-0s7ok4uw	1621	9	scale	scale	NN
cord-001835-0s7ok4uw	1621	10	production	production	NN
cord-001835-0s7ok4uw	1621	11	is	be	VBZ
cord-001835-0s7ok4uw	1621	12	in	in	IN
cord-001835-0s7ok4uw	1621	13	progress	progress	NN
cord-001835-0s7ok4uw	1621	14	.	.	.
cord-001835-0s7ok4uw	1622	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1622	2	aim	aim	VBP
cord-001835-0s7ok4uw	1622	3	to	to	TO
cord-001835-0s7ok4uw	1622	4	develop	develop	VB
cord-001835-0s7ok4uw	1622	5	SHuffle	SHuffle	NNP
cord-001835-0s7ok4uw	1622	6	as	as	IN
cord-001835-0s7ok4uw	1622	7	an	an	DT
cord-001835-0s7ok4uw	1622	8	easy	easy	JJ
cord-001835-0s7ok4uw	1622	9	,	,	,
cord-001835-0s7ok4uw	1622	10	fast	fast	JJ
cord-001835-0s7ok4uw	1622	11	,	,	,
cord-001835-0s7ok4uw	1622	12	robust	robust	JJ
cord-001835-0s7ok4uw	1622	13	platform	platform	NN
cord-001835-0s7ok4uw	1622	14	for	for	IN
cord-001835-0s7ok4uw	1622	15	antibody	antibody	NN
cord-001835-0s7ok4uw	1622	16	engineering	engineering	NN
cord-001835-0s7ok4uw	1622	17	,	,	,
cord-001835-0s7ok4uw	1622	18	screening	screening	NN
cord-001835-0s7ok4uw	1622	19	and	and	CC
cord-001835-0s7ok4uw	1622	20	expression	expression	NN
cord-001835-0s7ok4uw	1622	21	.	.	.
cord-001835-0s7ok4uw	1623	1	Experimental	experimental	JJ
cord-001835-0s7ok4uw	1623	2	and	and	CC
cord-001835-0s7ok4uw	1623	3	computational	computational	JJ
cord-001835-0s7ok4uw	1623	4	studies	study	NNS
cord-001835-0s7ok4uw	1623	5	of	of	IN
cord-001835-0s7ok4uw	1623	6	the	the	DT
cord-001835-0s7ok4uw	1623	7	effects	effect	NNS
cord-001835-0s7ok4uw	1623	8	of	of	IN
cord-001835-0s7ok4uw	1623	9	highly	highly	RB
cord-001835-0s7ok4uw	1623	10	concentrated	concentrated	JJ
cord-001835-0s7ok4uw	1623	11	solutes	solute	NNS
cord-001835-0s7ok4uw	1623	12	on	on	IN
cord-001835-0s7ok4uw	1623	13	proteins	protein	NNS
cord-001835-0s7ok4uw	1623	14	:	:	:
cord-001835-0s7ok4uw	1623	15	Insights	insight	NNS
cord-001835-0s7ok4uw	1623	16	into	into	IN
cord-001835-0s7ok4uw	1623	17	the	the	DT
cord-001835-0s7ok4uw	1623	18	causes	cause	NNS
cord-001835-0s7ok4uw	1623	19	and	and	CC
cord-001835-0s7ok4uw	1623	20	consequences	consequence	NNS
cord-001835-0s7ok4uw	1623	21	of	of	IN
cord-001835-0s7ok4uw	1623	22	quinary	quinary	JJ
cord-001835-0s7ok4uw	1623	23	protein	protein	NN
cord-001835-0s7ok4uw	1623	24	structure	structure	NN
cord-001835-0s7ok4uw	1623	25	and	and	CC
cord-001835-0s7ok4uw	1623	26	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	1623	27	organization	organization	NN
cord-001835-0s7ok4uw	1624	1	Most	Most	JJS
cord-001835-0s7ok4uw	1624	2	studies	study	NNS
cord-001835-0s7ok4uw	1624	3	of	of	IN
cord-001835-0s7ok4uw	1624	4	protein	protein	NN
cord-001835-0s7ok4uw	1624	5	structure	structure	NN
cord-001835-0s7ok4uw	1624	6	and	and	CC
cord-001835-0s7ok4uw	1624	7	function	function	NN
cord-001835-0s7ok4uw	1624	8	focus	focus	NN
cord-001835-0s7ok4uw	1624	9	on	on	IN
cord-001835-0s7ok4uw	1624	10	pure	pure	JJ
cord-001835-0s7ok4uw	1624	11	,	,	,
cord-001835-0s7ok4uw	1624	12	diluted	diluted	JJ
cord-001835-0s7ok4uw	1624	13	samples	sample	NNS
cord-001835-0s7ok4uw	1624	14	;	;	:
cord-001835-0s7ok4uw	1624	15	however	however	RB
cord-001835-0s7ok4uw	1624	16	,	,	,
cord-001835-0s7ok4uw	1624	17	real	real	JJ
cord-001835-0s7ok4uw	1624	18	-	-	HYPH
cord-001835-0s7ok4uw	1624	19	world	world	NN
cord-001835-0s7ok4uw	1624	20	biochemistry	biochemistry	NN
cord-001835-0s7ok4uw	1624	21	and	and	CC
cord-001835-0s7ok4uw	1624	22	typical	typical	JJ
cord-001835-0s7ok4uw	1624	23	biotechnological	biotechnological	JJ
cord-001835-0s7ok4uw	1624	24	applications	application	NNS
cord-001835-0s7ok4uw	1624	25	of	of	IN
cord-001835-0s7ok4uw	1624	26	proteins	protein	NNS
cord-001835-0s7ok4uw	1624	27	take	take	VBP
cord-001835-0s7ok4uw	1624	28	place	place	NN
cord-001835-0s7ok4uw	1624	29	in	in	IN
cord-001835-0s7ok4uw	1624	30	complex	complex	JJ
cord-001835-0s7ok4uw	1624	31	media	medium	NNS
cord-001835-0s7ok4uw	1624	32	with	with	IN
cord-001835-0s7ok4uw	1624	33	very	very	RB
cord-001835-0s7ok4uw	1624	34	high	high	JJ
cord-001835-0s7ok4uw	1624	35	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1624	36	of	of	IN
cord-001835-0s7ok4uw	1624	37	solutes	solute	NNS
cord-001835-0s7ok4uw	1624	38	(	(	-LRB-
cord-001835-0s7ok4uw	1624	39	100	100	CD
cord-001835-0s7ok4uw	1624	40	-	-	SYM
cord-001835-0s7ok4uw	1624	41	400	400	CD
cord-001835-0s7ok4uw	1624	42	g	g	NN
cord-001835-0s7ok4uw	1624	43	/	/	SYM
cord-001835-0s7ok4uw	1624	44	L	L	NNP
cord-001835-0s7ok4uw	1624	45	)	)	-RRB-
cord-001835-0s7ok4uw	1624	46	of	of	IN
cord-001835-0s7ok4uw	1624	47	varied	varied	JJ
cord-001835-0s7ok4uw	1624	48	size	size	NN
cord-001835-0s7ok4uw	1624	49	and	and	CC
cord-001835-0s7ok4uw	1624	50	chemical	chemical	NN
cord-001835-0s7ok4uw	1624	51	nature	nature	NN
cord-001835-0s7ok4uw	1624	52	.	.	.
cord-001835-0s7ok4uw	1625	1	On	on	IN
cord-001835-0s7ok4uw	1625	2	one	one	CD
cord-001835-0s7ok4uw	1625	3	side	side	NN
cord-001835-0s7ok4uw	1625	4	,	,	,
cord-001835-0s7ok4uw	1625	5	this	this	DT
cord-001835-0s7ok4uw	1625	6	has	have	VBZ
cord-001835-0s7ok4uw	1625	7	recently	recently	RB
cord-001835-0s7ok4uw	1625	8	fostered	foster	VBN
cord-001835-0s7ok4uw	1625	9	the	the	DT
cord-001835-0s7ok4uw	1625	10	study	study	NN
cord-001835-0s7ok4uw	1625	11	of	of	IN
cord-001835-0s7ok4uw	1625	12	proteins	protein	NNS
cord-001835-0s7ok4uw	1625	13	in	in	IN
cord-001835-0s7ok4uw	1625	14	vivo	vivo	NN
cord-001835-0s7ok4uw	1625	15	,	,	,
cord-001835-0s7ok4uw	1625	16	in	in	IN
cord-001835-0s7ok4uw	1625	17	cell	cell	NN
cord-001835-0s7ok4uw	1625	18	,	,	,
cord-001835-0s7ok4uw	1625	19	or	or	CC
cord-001835-0s7ok4uw	1625	20	at	at	IN
cord-001835-0s7ok4uw	1625	21	least	least	JJS
cord-001835-0s7ok4uw	1625	22	in	in	IN
cord-001835-0s7ok4uw	1625	23	media	medium	NNS
cord-001835-0s7ok4uw	1625	24	mimicking	mimic	VBG
cord-001835-0s7ok4uw	1625	25	the	the	DT
cord-001835-0s7ok4uw	1625	26	native	native	JJ
cord-001835-0s7ok4uw	1625	27	conditions	condition	NNS
cord-001835-0s7ok4uw	1625	28	.	.	.
cord-001835-0s7ok4uw	1626	1	On	on	IN
cord-001835-0s7ok4uw	1626	2	the	the	DT
cord-001835-0s7ok4uw	1626	3	other	other	JJ
cord-001835-0s7ok4uw	1626	4	hand	hand	NN
cord-001835-0s7ok4uw	1626	5	,	,	,
cord-001835-0s7ok4uw	1626	6	physical	physical	JJ
cord-001835-0s7ok4uw	1626	7	chemistry	chemistry	NN
cord-001835-0s7ok4uw	1626	8	has	have	VBZ
cord-001835-0s7ok4uw	1626	9	for	for	IN
cord-001835-0s7ok4uw	1626	10	a	a	DT
cord-001835-0s7ok4uw	1626	11	long	long	JJ
cord-001835-0s7ok4uw	1626	12	time	time	NN
cord-001835-0s7ok4uw	1626	13	studied	study	VBD
cord-001835-0s7ok4uw	1626	14	the	the	DT
cord-001835-0s7ok4uw	1626	15	general	general	JJ
cord-001835-0s7ok4uw	1626	16	effects	effect	NNS
cord-001835-0s7ok4uw	1626	17	of	of	IN
cord-001835-0s7ok4uw	1626	18	crowded	crowded	JJ
cord-001835-0s7ok4uw	1626	19	and	and	CC
cord-001835-0s7ok4uw	1626	20	viscous	viscous	JJ
cord-001835-0s7ok4uw	1626	21	conditions	condition	NNS
cord-001835-0s7ok4uw	1626	22	on	on	IN
cord-001835-0s7ok4uw	1626	23	proteins	protein	NNS
cord-001835-0s7ok4uw	1626	24	,	,	,
cord-001835-0s7ok4uw	1626	25	looking	look	VBG
cord-001835-0s7ok4uw	1626	26	mainly	mainly	RB
cord-001835-0s7ok4uw	1626	27	at	at	IN
cord-001835-0s7ok4uw	1626	28	coarse	coarse	JJ
cord-001835-0s7ok4uw	1626	29	traits	trait	NNS
cord-001835-0s7ok4uw	1626	30	like	like	IN
cord-001835-0s7ok4uw	1626	31	diffusion	diffusion	NN
cord-001835-0s7ok4uw	1626	32	and	and	CC
cord-001835-0s7ok4uw	1626	33	stability	stability	NN
cord-001835-0s7ok4uw	1626	34	.	.	.
cord-001835-0s7ok4uw	1627	1	But	but	CC
cord-001835-0s7ok4uw	1627	2	the	the	DT
cord-001835-0s7ok4uw	1627	3	general	general	JJ
cord-001835-0s7ok4uw	1627	4	effects	effect	NNS
cord-001835-0s7ok4uw	1627	5	on	on	IN
cord-001835-0s7ok4uw	1627	6	traits	trait	NNS
cord-001835-0s7ok4uw	1627	7	relevant	relevant	JJ
cord-001835-0s7ok4uw	1627	8	at	at	IN
cord-001835-0s7ok4uw	1627	9	atomic	atomic	JJ
cord-001835-0s7ok4uw	1627	10	/	/	SYM
cord-001835-0s7ok4uw	1627	11	residue	residue	NN
cord-001835-0s7ok4uw	1627	12	resolutions	resolution	NNS
cord-001835-0s7ok4uw	1627	13	have	have	VBP
cord-001835-0s7ok4uw	1627	14	been	be	VBN
cord-001835-0s7ok4uw	1627	15	less	less	RBR
cord-001835-0s7ok4uw	1627	16	studied	study	VBN
cord-001835-0s7ok4uw	1627	17	,	,	,
cord-001835-0s7ok4uw	1627	18	and	and	CC
cord-001835-0s7ok4uw	1627	19	one	one	CD
cord-001835-0s7ok4uw	1627	20	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	1627	21	issue	issue	NN
cord-001835-0s7ok4uw	1627	22	remains	remain	VBZ
cord-001835-0s7ok4uw	1627	23	unsolved	unsolved	JJ
cord-001835-0s7ok4uw	1627	24	:	:	:
cord-001835-0s7ok4uw	1627	25	to	to	TO
cord-001835-0s7ok4uw	1627	26	what	what	WDT
cord-001835-0s7ok4uw	1627	27	extent	extent	NN
cord-001835-0s7ok4uw	1627	28	are	be	VBP
cord-001835-0s7ok4uw	1627	29	proteins	protein	NNS
cord-001835-0s7ok4uw	1627	30	forced	force	VBN
cord-001835-0s7ok4uw	1627	31	into	into	IN
cord-001835-0s7ok4uw	1627	32	interactions	interaction	NNS
cord-001835-0s7ok4uw	1627	33	with	with	IN
cord-001835-0s7ok4uw	1627	34	highly	highly	RB
cord-001835-0s7ok4uw	1627	35	concentrated	concentrated	JJ
cord-001835-0s7ok4uw	1627	36	solutes	solute	NNS
cord-001835-0s7ok4uw	1627	37	,	,	,
cord-001835-0s7ok4uw	1627	38	and	and	CC
cord-001835-0s7ok4uw	1627	39	with	with	IN
cord-001835-0s7ok4uw	1627	40	what	what	WP
cord-001835-0s7ok4uw	1627	41	direct	direct	JJ
cord-001835-0s7ok4uw	1627	42	consequences	consequence	NNS
cord-001835-0s7ok4uw	1627	43	?	?	.
cord-001835-0s7ok4uw	1628	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	1628	2	will	will	MD
cord-001835-0s7ok4uw	1628	3	present	present	VB
cord-001835-0s7ok4uw	1628	4	here	here	RB
cord-001835-0s7ok4uw	1628	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1628	6	ongoing	ongoing	JJ
cord-001835-0s7ok4uw	1628	7	efforts	effort	NNS
cord-001835-0s7ok4uw	1628	8	to	to	TO
cord-001835-0s7ok4uw	1628	9	dissect	dissect	VB
cord-001835-0s7ok4uw	1628	10	the	the	DT
cord-001835-0s7ok4uw	1628	11	fine	fine	JJ
cord-001835-0s7ok4uw	1628	12	effects	effect	NNS
cord-001835-0s7ok4uw	1628	13	of	of	IN
cord-001835-0s7ok4uw	1628	14	high	high	JJ
cord-001835-0s7ok4uw	1628	15	solute	solute	NN
cord-001835-0s7ok4uw	1628	16	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1628	17	and	and	CC
cord-001835-0s7ok4uw	1628	18	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	1628	19	crowding	crowd	VBG
cord-001835-0s7ok4uw	1628	20	on	on	IN
cord-001835-0s7ok4uw	1628	21	proteins	protein	NNS
cord-001835-0s7ok4uw	1628	22	,	,	,
cord-001835-0s7ok4uw	1628	23	based	base	VBN
cord-001835-0s7ok4uw	1628	24	on	on	IN
cord-001835-0s7ok4uw	1628	25	NMR	NMR	NNP
cord-001835-0s7ok4uw	1628	26	experiments	experiment	NNS
cord-001835-0s7ok4uw	1628	27	and	and	CC
cord-001835-0s7ok4uw	1628	28	MD	MD	NNP
cord-001835-0s7ok4uw	1628	29	simulations	simulation	NNS
cord-001835-0s7ok4uw	1628	30	,	,	,
cord-001835-0s7ok4uw	1628	31	two	two	CD
cord-001835-0s7ok4uw	1628	32	complementary	complementary	JJ
cord-001835-0s7ok4uw	1628	33	techniques	technique	NNS
cord-001835-0s7ok4uw	1628	34	of	of	IN
cord-001835-0s7ok4uw	1628	35	high	high	JJ
cord-001835-0s7ok4uw	1628	36	spatial	spatial	JJ
cord-001835-0s7ok4uw	1628	37	and	and	CC
cord-001835-0s7ok4uw	1628	38	temporal	temporal	JJ
cord-001835-0s7ok4uw	1628	39	resolutions	resolution	NNS
cord-001835-0s7ok4uw	1628	40	.	.	.
cord-001835-0s7ok4uw	1629	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1629	2	results	result	NNS
cord-001835-0s7ok4uw	1629	3	show	show	VBP
cord-001835-0s7ok4uw	1629	4	that	that	IN
cord-001835-0s7ok4uw	1629	5	smaller	small	JJR
cord-001835-0s7ok4uw	1629	6	solutes	solute	NNS
cord-001835-0s7ok4uw	1629	7	are	be	VBP
cord-001835-0s7ok4uw	1629	8	prone	prone	JJ
cord-001835-0s7ok4uw	1629	9	to	to	IN
cord-001835-0s7ok4uw	1629	10	extensive	extensive	JJ
cord-001835-0s7ok4uw	1629	11	interactions	interaction	NNS
cord-001835-0s7ok4uw	1629	12	with	with	IN
cord-001835-0s7ok4uw	1629	13	proteins	protein	NNS
cord-001835-0s7ok4uw	1629	14	when	when	WRB
cord-001835-0s7ok4uw	1629	15	at	at	IN
cord-001835-0s7ok4uw	1629	16	high	high	JJ
cord-001835-0s7ok4uw	1629	17	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1629	18	while	while	IN
cord-001835-0s7ok4uw	1629	19	large	large	JJ
cord-001835-0s7ok4uw	1629	20	solutes	solute	NNS
cord-001835-0s7ok4uw	1629	21	act	act	VBP
cord-001835-0s7ok4uw	1629	22	chiefly	chiefly	RB
cord-001835-0s7ok4uw	1629	23	through	through	IN
cord-001835-0s7ok4uw	1629	24	excluded	exclude	VBN
cord-001835-0s7ok4uw	1629	25	-	-	HYPH
cord-001835-0s7ok4uw	1629	26	volume	volume	NN
cord-001835-0s7ok4uw	1629	27	effects	effect	NNS
cord-001835-0s7ok4uw	1629	28	.	.	.
cord-001835-0s7ok4uw	1630	1	Overall	overall	RB
cord-001835-0s7ok4uw	1630	2	,	,	,
cord-001835-0s7ok4uw	1630	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1630	4	observe	observe	VBP
cord-001835-0s7ok4uw	1630	5	location	location	NN
cord-001835-0s7ok4uw	1630	6	-	-	HYPH
cord-001835-0s7ok4uw	1630	7	specific	specific	JJ
cord-001835-0s7ok4uw	1630	8	perturbations	perturbation	NNS
cord-001835-0s7ok4uw	1630	9	of	of	IN
cord-001835-0s7ok4uw	1630	10	a	a	DT
cord-001835-0s7ok4uw	1630	11	protein	protein	NN
cord-001835-0s7ok4uw	1630	12	's	's	POS
cord-001835-0s7ok4uw	1630	13	surface	surface	NN
cord-001835-0s7ok4uw	1630	14	,	,	,
cord-001835-0s7ok4uw	1630	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1630	16	internal	internal	JJ
cord-001835-0s7ok4uw	1630	17	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1630	18	and	and	CC
cord-001835-0s7ok4uw	1630	19	internal	internal	JJ
cord-001835-0s7ok4uw	1630	20	dielectrics	dielectric	NNS
cord-001835-0s7ok4uw	1630	21	,	,	,
cord-001835-0s7ok4uw	1630	22	and	and	CC
cord-001835-0s7ok4uw	1630	23	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1630	24	hydration	hydration	NN
cord-001835-0s7ok4uw	1630	25	,	,	,
cord-001835-0s7ok4uw	1630	26	all	all	DT
cord-001835-0s7ok4uw	1630	27	very	very	RB
cord-001835-0s7ok4uw	1630	28	dependently	dependently	RB
cord-001835-0s7ok4uw	1630	29	on	on	IN
cord-001835-0s7ok4uw	1630	30	the	the	DT
cord-001835-0s7ok4uw	1630	31	solute	solute	NN
cord-001835-0s7ok4uw	1630	32	's	's	POS
cord-001835-0s7ok4uw	1630	33	size	size	NN
cord-001835-0s7ok4uw	1630	34	and	and	CC
cord-001835-0s7ok4uw	1630	35	chemical	chemical	NN
cord-001835-0s7ok4uw	1630	36	nature	nature	NN
cord-001835-0s7ok4uw	1630	37	.	.	.
cord-001835-0s7ok4uw	1631	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1631	2	results	result	NNS
cord-001835-0s7ok4uw	1631	3	support	support	VBP
cord-001835-0s7ok4uw	1631	4	the	the	DT
cord-001835-0s7ok4uw	1631	5	growing	grow	VBG
cord-001835-0s7ok4uw	1631	6	notion	notion	NN
cord-001835-0s7ok4uw	1631	7	that	that	IN
cord-001835-0s7ok4uw	1631	8	proteins	protein	NNS
cord-001835-0s7ok4uw	1631	9	should	should	MD
cord-001835-0s7ok4uw	1631	10	be	be	VB
cord-001835-0s7ok4uw	1631	11	studied	study	VBN
cord-001835-0s7ok4uw	1631	12	in	in	IN
cord-001835-0s7ok4uw	1631	13	native	native	JJ
cord-001835-0s7ok4uw	1631	14	-	-	HYPH
cord-001835-0s7ok4uw	1631	15	like	like	JJ
cord-001835-0s7ok4uw	1631	16	media	medium	NNS
cord-001835-0s7ok4uw	1631	17	,	,	,
cord-001835-0s7ok4uw	1631	18	adding	add	VBG
cord-001835-0s7ok4uw	1631	19	that	that	IN
cord-001835-0s7ok4uw	1631	20	not	not	RB
cord-001835-0s7ok4uw	1631	21	only	only	RB
cord-001835-0s7ok4uw	1631	22	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	1631	23	crowders	crowder	NNS
cord-001835-0s7ok4uw	1631	24	but	but	CC
cord-001835-0s7ok4uw	1631	25	also	also	RB
cord-001835-0s7ok4uw	1631	26	small	small	JJ
cord-001835-0s7ok4uw	1631	27	molecules	molecule	NNS
cord-001835-0s7ok4uw	1631	28	should	should	MD
cord-001835-0s7ok4uw	1631	29	be	be	VB
cord-001835-0s7ok4uw	1631	30	considered	consider	VBN
cord-001835-0s7ok4uw	1631	31	in	in	IN
cord-001835-0s7ok4uw	1631	32	these	these	DT
cord-001835-0s7ok4uw	1631	33	studies	study	NNS
cord-001835-0s7ok4uw	1631	34	.	.	.
cord-001835-0s7ok4uw	1632	1	Last	last	RB
cord-001835-0s7ok4uw	1632	2	,	,	,
cord-001835-0s7ok4uw	1632	3	the	the	DT
cord-001835-0s7ok4uw	1632	4	fact	fact	NN
cord-001835-0s7ok4uw	1632	5	that	that	IN
cord-001835-0s7ok4uw	1632	6	high	high	JJ
cord-001835-0s7ok4uw	1632	7	-	-	HYPH
cord-001835-0s7ok4uw	1632	8	concentration	concentration	NN
cord-001835-0s7ok4uw	1632	9	conditions	condition	NNS
cord-001835-0s7ok4uw	1632	10	affect	affect	VBP
cord-001835-0s7ok4uw	1632	11	far	far	RB
cord-001835-0s7ok4uw	1632	12	more	more	JJR
cord-001835-0s7ok4uw	1632	13	than	than	IN
cord-001835-0s7ok4uw	1632	14	a	a	DT
cord-001835-0s7ok4uw	1632	15	protein	protein	NN
cord-001835-0s7ok4uw	1632	16	's	's	POS
cord-001835-0s7ok4uw	1632	17	diffusion	diffusion	NN
cord-001835-0s7ok4uw	1632	18	rate	rate	NN
cord-001835-0s7ok4uw	1632	19	and	and	CC
cord-001835-0s7ok4uw	1632	20	stability	stability	NN
cord-001835-0s7ok4uw	1632	21	suggests	suggest	VBZ
cord-001835-0s7ok4uw	1632	22	critical	critical	JJ
cord-001835-0s7ok4uw	1632	23	consequences	consequence	NNS
cord-001835-0s7ok4uw	1632	24	of	of	IN
cord-001835-0s7ok4uw	1632	25	quinary	quinary	JJ
cord-001835-0s7ok4uw	1632	26	protein	protein	NN
cord-001835-0s7ok4uw	1632	27	structure	structure	NN
cord-001835-0s7ok4uw	1632	28	and	and	CC
cord-001835-0s7ok4uw	1632	29	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	1632	30	organization	organization	NN
cord-001835-0s7ok4uw	1632	31	on	on	IN
cord-001835-0s7ok4uw	1632	32	the	the	DT
cord-001835-0s7ok4uw	1632	33	regulation	regulation	NN
cord-001835-0s7ok4uw	1632	34	of	of	IN
cord-001835-0s7ok4uw	1632	35	proteins	protein	NNS
cord-001835-0s7ok4uw	1632	36	within	within	IN
cord-001835-0s7ok4uw	1632	37	cellular	cellular	JJ
cord-001835-0s7ok4uw	1632	38	biochemistry	biochemistry	NN
cord-001835-0s7ok4uw	1632	39	.	.	.
cord-001835-0s7ok4uw	1633	1	Aldona	Aldona	NNP
cord-001835-0s7ok4uw	1633	2	Jeli	Jeli	NNP
cord-001835-0s7ok4uw	1633	3	nska	nska	NNP
cord-001835-0s7ok4uw	1633	4	1	1	CD
cord-001835-0s7ok4uw	1633	5	,	,	,
cord-001835-0s7ok4uw	1633	6	Anna	Anna	NNP
cord-001835-0s7ok4uw	1633	7	Lewandrowska	Lewandrowska	NNP
cord-001835-0s7ok4uw	1633	8	1	1	CD
cord-001835-0s7ok4uw	1633	9	,	,	,
cord-001835-0s7ok4uw	1633	10	Robert	Robert	NNP
cord-001835-0s7ok4uw	1633	11	Hołyst	Hołyst	NNP
cord-001835-0s7ok4uw	1633	12	1	1	CD
cord-001835-0s7ok4uw	1633	13	1	1	CD
cord-001835-0s7ok4uw	1634	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1634	2	developed	develop	VBD
cord-001835-0s7ok4uw	1634	3	an	an	DT
cord-001835-0s7ok4uw	1634	4	analytical	analytical	JJ
cord-001835-0s7ok4uw	1634	5	technique	technique	NN
cord-001835-0s7ok4uw	1634	6	for	for	IN
cord-001835-0s7ok4uw	1634	7	the	the	DT
cord-001835-0s7ok4uw	1634	8	study	study	NN
cord-001835-0s7ok4uw	1634	9	of	of	IN
cord-001835-0s7ok4uw	1634	10	interactions	interaction	NNS
cord-001835-0s7ok4uw	1634	11	of	of	IN
cord-001835-0s7ok4uw	1634	12	ligands	ligand	NNS
cord-001835-0s7ok4uw	1634	13	(	(	-LRB-
cord-001835-0s7ok4uw	1634	14	e.g.	e.g.	RB
cord-001835-0s7ok4uw	1634	15	cefaclor	cefaclor	NNP
cord-001835-0s7ok4uw	1634	16	,	,	,
cord-001835-0s7ok4uw	1634	17	etodolac	etodolac	NNP
cord-001835-0s7ok4uw	1634	18	,	,	,
cord-001835-0s7ok4uw	1634	19	sulindac	sulindac	NNP
cord-001835-0s7ok4uw	1634	20	)	)	-RRB-
cord-001835-0s7ok4uw	1634	21	with	with	IN
cord-001835-0s7ok4uw	1634	22	most	most	JJS
cord-001835-0s7ok4uw	1634	23	abundant	abundant	JJ
cord-001835-0s7ok4uw	1634	24	blood	blood	NN
cord-001835-0s7ok4uw	1634	25	protein	protein	NN
cord-001835-0s7ok4uw	1634	26	(	(	-LRB-
cord-001835-0s7ok4uw	1634	27	e.g.	e.g.	JJ
cord-001835-0s7ok4uw	1634	28	bovine	bovine	JJ
cord-001835-0s7ok4uw	1634	29	serum	serum	NN
cord-001835-0s7ok4uw	1634	30	albumin	albumin	NN
cord-001835-0s7ok4uw	1634	31	)	)	-RRB-
cord-001835-0s7ok4uw	1634	32	using	use	VBG
cord-001835-0s7ok4uw	1634	33	the	the	DT
cord-001835-0s7ok4uw	1634	34	Flow	Flow	NNP
cord-001835-0s7ok4uw	1634	35	Injection	Injection	NNP
cord-001835-0s7ok4uw	1634	36	Method	Method	NNP
cord-001835-0s7ok4uw	1634	37	.	.	.
cord-001835-0s7ok4uw	1635	1	The	the	DT
cord-001835-0s7ok4uw	1635	2	experiments	experiment	NNS
cord-001835-0s7ok4uw	1635	3	were	be	VBD
cord-001835-0s7ok4uw	1635	4	conducted	conduct	VBN
cord-001835-0s7ok4uw	1635	5	at	at	IN
cord-001835-0s7ok4uw	1635	6	high	high	JJ
cord-001835-0s7ok4uw	1635	7	flow	flow	NN
cord-001835-0s7ok4uw	1635	8	rates	rate	NNS
cord-001835-0s7ok4uw	1635	9	(	(	-LRB-
cord-001835-0s7ok4uw	1635	10	31	31	CD
cord-001835-0s7ok4uw	1635	11	cm	cm	NNS
cord-001835-0s7ok4uw	1635	12	/	/	SYM
cord-001835-0s7ok4uw	1635	13	s	s	NN
cord-001835-0s7ok4uw	1635	14	)	)	-RRB-
cord-001835-0s7ok4uw	1635	15	in	in	IN
cord-001835-0s7ok4uw	1635	16	a	a	DT
cord-001835-0s7ok4uw	1635	17	long	long	JJ
cord-001835-0s7ok4uw	1635	18	(	(	-LRB-
cord-001835-0s7ok4uw	1635	19	>	>	NFP
cord-001835-0s7ok4uw	1635	20	15	15	CD
cord-001835-0s7ok4uw	1635	21	m	m	CD
cord-001835-0s7ok4uw	1635	22	)	)	-RRB-
cord-001835-0s7ok4uw	1635	23	,	,	,
cord-001835-0s7ok4uw	1635	24	thin	thin	JJ
cord-001835-0s7ok4uw	1635	25	(	(	-LRB-
cord-001835-0s7ok4uw	1635	26	250	250	CD
cord-001835-0s7ok4uw	1635	27	mm	mm	NNS
cord-001835-0s7ok4uw	1635	28	)	)	-RRB-
cord-001835-0s7ok4uw	1635	29	and	and	CC
cord-001835-0s7ok4uw	1635	30	coiled	coiled	JJ
cord-001835-0s7ok4uw	1635	31	capillaries	capillary	NNS
cord-001835-0s7ok4uw	1635	32	.	.	.
cord-001835-0s7ok4uw	1636	1	The	the	DT
cord-001835-0s7ok4uw	1636	2	compound	compound	NN
cord-001835-0s7ok4uw	1636	3	of	of	IN
cord-001835-0s7ok4uw	1636	4	interest	interest	NN
cord-001835-0s7ok4uw	1636	5	(	(	-LRB-
cord-001835-0s7ok4uw	1636	6	10	10	CD
cord-001835-0s7ok4uw	1636	7	ml	ml	NN
cord-001835-0s7ok4uw	1636	8	)	)	-RRB-
cord-001835-0s7ok4uw	1636	9	was	be	VBD
cord-001835-0s7ok4uw	1636	10	injected	inject	VBN
cord-001835-0s7ok4uw	1636	11	into	into	IN
cord-001835-0s7ok4uw	1636	12	carrier	carrier	NN
cord-001835-0s7ok4uw	1636	13	phase	phase	NN
cord-001835-0s7ok4uw	1636	14	,	,	,
cord-001835-0s7ok4uw	1636	15	which	which	WDT
cord-001835-0s7ok4uw	1636	16	moved	move	VBD
cord-001835-0s7ok4uw	1636	17	by	by	IN
cord-001835-0s7ok4uw	1636	18	the	the	DT
cord-001835-0s7ok4uw	1636	19	Poisseule	Poisseule	NNP
cord-001835-0s7ok4uw	1636	20	laminar	laminar	JJ
cord-001835-0s7ok4uw	1636	21	flow	flow	NN
cord-001835-0s7ok4uw	1636	22	.	.	.
cord-001835-0s7ok4uw	1637	1	At	at	IN
cord-001835-0s7ok4uw	1637	2	the	the	DT
cord-001835-0s7ok4uw	1637	3	detection	detection	NN
cord-001835-0s7ok4uw	1637	4	point	point	NN
cord-001835-0s7ok4uw	1637	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1637	6	measure	measure	VBP
cord-001835-0s7ok4uw	1637	7	the	the	DT
cord-001835-0s7ok4uw	1637	8	concentration	concentration	NN
cord-001835-0s7ok4uw	1637	9	distribution	distribution	NN
cord-001835-0s7ok4uw	1637	10	of	of	IN
cord-001835-0s7ok4uw	1637	11	the	the	DT
cord-001835-0s7ok4uw	1637	12	analyte	analyte	NN
cord-001835-0s7ok4uw	1637	13	.	.	.
cord-001835-0s7ok4uw	1638	1	The	the	DT
cord-001835-0s7ok4uw	1638	2	width	width	NN
cord-001835-0s7ok4uw	1638	3	of	of	IN
cord-001835-0s7ok4uw	1638	4	the	the	DT
cord-001835-0s7ok4uw	1638	5	final	final	JJ
cord-001835-0s7ok4uw	1638	6	profile	profile	NN
cord-001835-0s7ok4uw	1638	7	of	of	IN
cord-001835-0s7ok4uw	1638	8	the	the	DT
cord-001835-0s7ok4uw	1638	9	analyte	analyte	JJ
cord-001835-0s7ok4uw	1638	10	concentration	concentration	NN
cord-001835-0s7ok4uw	1638	11	is	be	VBZ
cord-001835-0s7ok4uw	1638	12	inversely	inversely	RB
cord-001835-0s7ok4uw	1638	13	proportional	proportional	JJ
cord-001835-0s7ok4uw	1638	14	to	to	IN
cord-001835-0s7ok4uw	1638	15	the	the	DT
cord-001835-0s7ok4uw	1638	16	effective	effective	JJ
cord-001835-0s7ok4uw	1638	17	diffusion	diffusion	NN
cord-001835-0s7ok4uw	1638	18	coefficient	coefficient	NN
cord-001835-0s7ok4uw	1638	19	of	of	IN
cord-001835-0s7ok4uw	1638	20	the	the	DT
cord-001835-0s7ok4uw	1638	21	analyte	analyte	NN
cord-001835-0s7ok4uw	1638	22	.	.	.
cord-001835-0s7ok4uw	1639	1	From	from	IN
cord-001835-0s7ok4uw	1639	2	the	the	DT
cord-001835-0s7ok4uw	1639	3	differences	difference	NNS
cord-001835-0s7ok4uw	1639	4	between	between	IN
cord-001835-0s7ok4uw	1639	5	the	the	DT
cord-001835-0s7ok4uw	1639	6	widths	width	NNS
cord-001835-0s7ok4uw	1639	7	of	of	IN
cord-001835-0s7ok4uw	1639	8	the	the	DT
cord-001835-0s7ok4uw	1639	9	concentration	concentration	NN
cord-001835-0s7ok4uw	1639	10	distribution	distribution	NN
cord-001835-0s7ok4uw	1639	11	of	of	IN
cord-001835-0s7ok4uw	1639	12	free	free	JJ
cord-001835-0s7ok4uw	1639	13	and	and	CC
cord-001835-0s7ok4uw	1639	14	bound	bound	JJ
cord-001835-0s7ok4uw	1639	15	ligand	ligand	NN
cord-001835-0s7ok4uw	1639	16	we	-PRON-	PRP
cord-001835-0s7ok4uw	1639	17	can	can	MD
cord-001835-0s7ok4uw	1639	18	determine	determine	VB
cord-001835-0s7ok4uw	1639	19	value	value	NN
cord-001835-0s7ok4uw	1639	20	of	of	IN
cord-001835-0s7ok4uw	1639	21	the	the	DT
cord-001835-0s7ok4uw	1639	22	association	association	NN
cord-001835-0s7ok4uw	1639	23	constant	constant	NN
cord-001835-0s7ok4uw	1639	24	.	.	.
cord-001835-0s7ok4uw	1640	1	Carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	1640	2	binding	bind	VBG
cord-001835-0s7ok4uw	1640	3	modules	module	NNS
cord-001835-0s7ok4uw	1640	4	(	(	-LRB-
cord-001835-0s7ok4uw	1640	5	CBMs	CBMs	NNP
cord-001835-0s7ok4uw	1640	6	)	)	-RRB-
cord-001835-0s7ok4uw	1640	7	,	,	,
cord-001835-0s7ok4uw	1640	8	which	which	WDT
cord-001835-0s7ok4uw	1640	9	are	be	VBP
cord-001835-0s7ok4uw	1640	10	defined	define	VBN
cord-001835-0s7ok4uw	1640	11	as	as	IN
cord-001835-0s7ok4uw	1640	12	contiguous	contiguous	JJ
cord-001835-0s7ok4uw	1640	13	amino	amino	NN
cord-001835-0s7ok4uw	1640	14	acid	acid	NN
cord-001835-0s7ok4uw	1640	15	sequences	sequence	NNS
cord-001835-0s7ok4uw	1640	16	within	within	IN
cord-001835-0s7ok4uw	1640	17	a	a	DT
cord-001835-0s7ok4uw	1640	18	carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	1640	19	-	-	HYPH
cord-001835-0s7ok4uw	1640	20	active	active	JJ
cord-001835-0s7ok4uw	1640	21	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1640	22	,	,	,
cord-001835-0s7ok4uw	1640	23	have	have	VBP
cord-001835-0s7ok4uw	1640	24	been	be	VBN
cord-001835-0s7ok4uw	1640	25	found	find	VBN
cord-001835-0s7ok4uw	1640	26	in	in	IN
cord-001835-0s7ok4uw	1640	27	both	both	CC
cord-001835-0s7ok4uw	1640	28	hydrolytic	hydrolytic	JJ
cord-001835-0s7ok4uw	1640	29	and	and	CC
cord-001835-0s7ok4uw	1640	30	non	non	JJ
cord-001835-0s7ok4uw	1640	31	-	-	JJ
cord-001835-0s7ok4uw	1640	32	hydrolytic	hydrolytic	JJ
cord-001835-0s7ok4uw	1640	33	proteins	protein	NNS
cord-001835-0s7ok4uw	1640	34	and	and	CC
cord-001835-0s7ok4uw	1640	35	are	be	VBP
cord-001835-0s7ok4uw	1640	36	classified	classify	VBN
cord-001835-0s7ok4uw	1640	37	into	into	IN
cord-001835-0s7ok4uw	1640	38	71	71	CD
cord-001835-0s7ok4uw	1640	39	families	family	NNS
cord-001835-0s7ok4uw	1640	40	,	,	,
cord-001835-0s7ok4uw	1640	41	according	accord	VBG
cord-001835-0s7ok4uw	1640	42	to	to	IN
cord-001835-0s7ok4uw	1640	43	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1640	44	primary	primary	JJ
cord-001835-0s7ok4uw	1640	45	structure	structure	NN
cord-001835-0s7ok4uw	1640	46	similarity	similarity	NN
cord-001835-0s7ok4uw	1640	47	.	.	.
cord-001835-0s7ok4uw	1641	1	The	the	DT
cord-001835-0s7ok4uw	1641	2	characterization	characterization	NN
cord-001835-0s7ok4uw	1641	3	of	of	IN
cord-001835-0s7ok4uw	1641	4	CBMs	cbm	NNS
cord-001835-0s7ok4uw	1641	5	by	by	IN
cord-001835-0s7ok4uw	1641	6	different	different	JJ
cord-001835-0s7ok4uw	1641	7	methods	method	NNS
cord-001835-0s7ok4uw	1641	8	has	have	VBZ
cord-001835-0s7ok4uw	1641	9	shown	show	VBN
cord-001835-0s7ok4uw	1641	10	that	that	IN
cord-001835-0s7ok4uw	1641	11	these	these	DT
cord-001835-0s7ok4uw	1641	12	modules	module	NNS
cord-001835-0s7ok4uw	1641	13	concentrate	concentrate	VBP
cord-001835-0s7ok4uw	1641	14	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	1641	15	on	on	IN
cord-001835-0s7ok4uw	1641	16	the	the	DT
cord-001835-0s7ok4uw	1641	17	surface	surface	NN
cord-001835-0s7ok4uw	1641	18	of	of	IN
cord-001835-0s7ok4uw	1641	19	polysaccharide	polysaccharide	NN
cord-001835-0s7ok4uw	1641	20	substrates	substrate	NNS
cord-001835-0s7ok4uw	1641	21	.	.	.
cord-001835-0s7ok4uw	1642	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1642	2	is	be	VBZ
cord-001835-0s7ok4uw	1642	3	thought	think	VBN
cord-001835-0s7ok4uw	1642	4	that	that	IN
cord-001835-0s7ok4uw	1642	5	maintaining	maintain	VBG
cord-001835-0s7ok4uw	1642	6	the	the	DT
cord-001835-0s7ok4uw	1642	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1642	8	in	in	IN
cord-001835-0s7ok4uw	1642	9	proximity	proximity	NN
cord-001835-0s7ok4uw	1642	10	with	with	IN
cord-001835-0s7ok4uw	1642	11	the	the	DT
cord-001835-0s7ok4uw	1642	12	substrate	substrate	NN
cord-001835-0s7ok4uw	1642	13	leads	lead	VBZ
cord-001835-0s7ok4uw	1642	14	to	to	IN
cord-001835-0s7ok4uw	1642	15	more	more	RBR
cord-001835-0s7ok4uw	1642	16	rapid	rapid	JJ
cord-001835-0s7ok4uw	1642	17	degradation	degradation	NN
cord-001835-0s7ok4uw	1642	18	of	of	IN
cord-001835-0s7ok4uw	1642	19	the	the	DT
cord-001835-0s7ok4uw	1642	20	polysaccharide	polysaccharide	NN
cord-001835-0s7ok4uw	1642	21	.	.	.
cord-001835-0s7ok4uw	1643	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	1643	2	,	,	,
cord-001835-0s7ok4uw	1643	3	the	the	DT
cord-001835-0s7ok4uw	1643	4	study	study	NN
cord-001835-0s7ok4uw	1643	5	of	of	IN
cord-001835-0s7ok4uw	1643	6	these	these	DT
cord-001835-0s7ok4uw	1643	7	kinds	kind	NNS
cord-001835-0s7ok4uw	1643	8	of	of	IN
cord-001835-0s7ok4uw	1643	9	modules	module	NNS
cord-001835-0s7ok4uw	1643	10	or	or	CC
cord-001835-0s7ok4uw	1643	11	domains	domain	NNS
cord-001835-0s7ok4uw	1643	12	is	be	VBZ
cord-001835-0s7ok4uw	1643	13	relevant	relevant	JJ
cord-001835-0s7ok4uw	1643	14	,	,	,
cord-001835-0s7ok4uw	1643	15	since	since	IN
cord-001835-0s7ok4uw	1643	16	they	-PRON-	PRP
cord-001835-0s7ok4uw	1643	17	are	be	VBP
cord-001835-0s7ok4uw	1643	18	involved	involve	VBN
cord-001835-0s7ok4uw	1643	19	in	in	IN
cord-001835-0s7ok4uw	1643	20	multiple	multiple	JJ
cord-001835-0s7ok4uw	1643	21	processes	process	NNS
cord-001835-0s7ok4uw	1643	22	in	in	IN
cord-001835-0s7ok4uw	1643	23	organisms	organism	NNS
cord-001835-0s7ok4uw	1643	24	,	,	,
cord-001835-0s7ok4uw	1643	25	like	like	IN
cord-001835-0s7ok4uw	1643	26	signaling	signaling	NN
cord-001835-0s7ok4uw	1643	27	,	,	,
cord-001835-0s7ok4uw	1643	28	defense	defense	NN
cord-001835-0s7ok4uw	1643	29	and	and	CC
cord-001835-0s7ok4uw	1643	30	metabolism	metabolism	NN
cord-001835-0s7ok4uw	1643	31	;	;	:
cord-001835-0s7ok4uw	1643	32	and	and	CC
cord-001835-0s7ok4uw	1643	33	some	some	DT
cord-001835-0s7ok4uw	1643	34	of	of	IN
cord-001835-0s7ok4uw	1643	35	them	-PRON-	PRP
cord-001835-0s7ok4uw	1643	36	are	be	VBP
cord-001835-0s7ok4uw	1643	37	involved	involve	VBN
cord-001835-0s7ok4uw	1643	38	in	in	IN
cord-001835-0s7ok4uw	1643	39	allergenic	allergenic	JJ
cord-001835-0s7ok4uw	1643	40	responses	response	NNS
cord-001835-0s7ok4uw	1643	41	.	.	.
cord-001835-0s7ok4uw	1644	1	In	in	IN
cord-001835-0s7ok4uw	1644	2	the	the	DT
cord-001835-0s7ok4uw	1644	3	present	present	JJ
cord-001835-0s7ok4uw	1644	4	work	work	NN
cord-001835-0s7ok4uw	1644	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1644	6	studied	study	VBD
cord-001835-0s7ok4uw	1644	7	two	two	CD
cord-001835-0s7ok4uw	1644	8	different	different	JJ
cord-001835-0s7ok4uw	1644	9	models	model	NNS
cord-001835-0s7ok4uw	1644	10	:	:	:
cord-001835-0s7ok4uw	1645	1	The	the	DT
cord-001835-0s7ok4uw	1645	2	first	first	JJ
cord-001835-0s7ok4uw	1645	3	one	one	NN
cord-001835-0s7ok4uw	1645	4	is	be	VBZ
cord-001835-0s7ok4uw	1645	5	a	a	DT
cord-001835-0s7ok4uw	1645	6	CBM	CBM	NNP
cord-001835-0s7ok4uw	1645	7	of	of	IN
cord-001835-0s7ok4uw	1645	8	the	the	DT
cord-001835-0s7ok4uw	1645	9	family	family	NN
cord-001835-0s7ok4uw	1645	10	26	26	CD
cord-001835-0s7ok4uw	1645	11	from	from	IN
cord-001835-0s7ok4uw	1645	12	Lactobacillus	lactobacillus	NN
cord-001835-0s7ok4uw	1645	13	amylovorus	amylovorus	NNP
cord-001835-0s7ok4uw	1645	14	(	(	-LRB-
cord-001835-0s7ok4uw	1645	15	LaCBM26	LaCBM26	NNP
cord-001835-0s7ok4uw	1645	16	)	)	-RRB-
cord-001835-0s7ok4uw	1645	17	that	that	WDT
cord-001835-0s7ok4uw	1645	18	binds	bind	VBZ
cord-001835-0s7ok4uw	1645	19	starch	starch	NN
cord-001835-0s7ok4uw	1645	20	These	these	DT
cord-001835-0s7ok4uw	1645	21	domains	domain	NNS
cord-001835-0s7ok4uw	1645	22	are	be	VBP
cord-001835-0s7ok4uw	1645	23	present	present	JJ
cord-001835-0s7ok4uw	1645	24	in	in	IN
cord-001835-0s7ok4uw	1645	25	a	a	DT
cord-001835-0s7ok4uw	1645	26	a	a	DT
cord-001835-0s7ok4uw	1645	27	-	-	HYPH
cord-001835-0s7ok4uw	1645	28	amylase	amylase	NN
cord-001835-0s7ok4uw	1645	29	like	like	IN
cord-001835-0s7ok4uw	1645	30	a	a	DT
cord-001835-0s7ok4uw	1645	31	repetitive	repetitive	JJ
cord-001835-0s7ok4uw	1645	32	tandem	tandem	NN
cord-001835-0s7ok4uw	1645	33	of	of	IN
cord-001835-0s7ok4uw	1645	34	five	five	CD
cord-001835-0s7ok4uw	1645	35	modules	module	NNS
cord-001835-0s7ok4uw	1645	36	that	that	WDT
cord-001835-0s7ok4uw	1645	37	are	be	VBP
cord-001835-0s7ok4uw	1645	38	consecutive	consecutive	JJ
cord-001835-0s7ok4uw	1645	39	and	and	CC
cord-001835-0s7ok4uw	1645	40	do	do	VBP
cord-001835-0s7ok4uw	1645	41	not	not	RB
cord-001835-0s7ok4uw	1645	42	present	present	VB
cord-001835-0s7ok4uw	1645	43	connectors	connector	NNS
cord-001835-0s7ok4uw	1645	44	.	.	.
cord-001835-0s7ok4uw	1646	1	By	by	IN
cord-001835-0s7ok4uw	1646	2	means	mean	NNS
cord-001835-0s7ok4uw	1646	3	of	of	IN
cord-001835-0s7ok4uw	1646	4	ITC	ITC	NNP
cord-001835-0s7ok4uw	1646	5	and	and	CC
cord-001835-0s7ok4uw	1646	6	using	use	VBG
cord-001835-0s7ok4uw	1646	7	a	a	DT
cord-001835-0s7ok4uw	1646	8	single	single	JJ
cord-001835-0s7ok4uw	1646	9	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1646	10	LaCBM26	LaCBM26	NNP
cord-001835-0s7ok4uw	1646	11	domain	domain	NN
cord-001835-0s7ok4uw	1646	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	1646	13	determined	determine	VBD
cord-001835-0s7ok4uw	1646	14	a	a	DT
cord-001835-0s7ok4uw	1646	15	Ka	Ka	NNP
cord-001835-0s7ok4uw	1646	16	5	5	CD
cord-001835-0s7ok4uw	1646	17	2.31x104	2.31x104	CD
cord-001835-0s7ok4uw	1646	18	M-1	M-1	NNP
cord-001835-0s7ok4uw	1646	19	for	for	IN
cord-001835-0s7ok4uw	1646	20	b	b	NN
cord-001835-0s7ok4uw	1646	21	-	-	HYPH
cord-001835-0s7ok4uw	1646	22	cyclodextrin	cyclodextrin	NN
cord-001835-0s7ok4uw	1646	23	and	and	CC
cord-001835-0s7ok4uw	1646	24	a	a	DT
cord-001835-0s7ok4uw	1646	25	Ka	Ka	NNP
cord-001835-0s7ok4uw	1646	26	5	5	CD
cord-001835-0s7ok4uw	1646	27	8.54x104	8.54x104	CD
cord-001835-0s7ok4uw	1646	28	M-1	M-1	NNP
cord-001835-0s7ok4uw	1646	29	for	for	IN
cord-001835-0s7ok4uw	1646	30	acyclodextrin	acyclodextrin	NNP
cord-001835-0s7ok4uw	1646	31	.	.	.
cord-001835-0s7ok4uw	1647	1	When	when	WRB
cord-001835-0s7ok4uw	1647	2	the	the	DT
cord-001835-0s7ok4uw	1647	3	number	number	NN
cord-001835-0s7ok4uw	1647	4	of	of	IN
cord-001835-0s7ok4uw	1647	5	consecutive	consecutive	JJ
cord-001835-0s7ok4uw	1647	6	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1647	7	modules	module	NNS
cord-001835-0s7ok4uw	1647	8	increased	increase	VBD
cord-001835-0s7ok4uw	1647	9	to	to	IN
cord-001835-0s7ok4uw	1647	10	three	three	CD
cord-001835-0s7ok4uw	1647	11	or	or	CC
cord-001835-0s7ok4uw	1647	12	five	five	CD
cord-001835-0s7ok4uw	1647	13	tandem	tandem	NN
cord-001835-0s7ok4uw	1647	14	modules	module	NNS
cord-001835-0s7ok4uw	1647	15	,	,	,
cord-001835-0s7ok4uw	1647	16	the	the	DT
cord-001835-0s7ok4uw	1647	17	Ka	Ka	NNP
cord-001835-0s7ok4uw	1647	18	values	value	NNS
cord-001835-0s7ok4uw	1647	19	increased	increase	VBD
cord-001835-0s7ok4uw	1647	20	to	to	IN
cord-001835-0s7ok4uw	1647	21	106	106	CD
cord-001835-0s7ok4uw	1647	22	M-1	M-1	NNP
cord-001835-0s7ok4uw	1647	23	;	;	:
cord-001835-0s7ok4uw	1647	24	however	however	RB
cord-001835-0s7ok4uw	1647	25	,	,	,
cord-001835-0s7ok4uw	1647	26	these	these	DT
cord-001835-0s7ok4uw	1647	27	constants	constant	NNS
cord-001835-0s7ok4uw	1647	28	did	do	VBD
cord-001835-0s7ok4uw	1647	29	not	not	RB
cord-001835-0s7ok4uw	1647	30	show	show	VB
cord-001835-0s7ok4uw	1647	31	an	an	DT
cord-001835-0s7ok4uw	1647	32	additive	additive	NN
cord-001835-0s7ok4uw	1647	33	or	or	CC
cord-001835-0s7ok4uw	1647	34	a	a	DT
cord-001835-0s7ok4uw	1647	35	synergic	synergic	JJ
cord-001835-0s7ok4uw	1647	36	effect	effect	NN
cord-001835-0s7ok4uw	1647	37	.	.	.
cord-001835-0s7ok4uw	1648	1	For	for	IN
cord-001835-0s7ok4uw	1648	2	these	these	DT
cord-001835-0s7ok4uw	1648	3	experiments	experiment	NNS
cord-001835-0s7ok4uw	1648	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	1648	5	fitted	fit	VBD
cord-001835-0s7ok4uw	1648	6	the	the	DT
cord-001835-0s7ok4uw	1648	7	isotherms	isotherm	NNS
cord-001835-0s7ok4uw	1648	8	to	to	IN
cord-001835-0s7ok4uw	1648	9	different	different	JJ
cord-001835-0s7ok4uw	1648	10	models	model	NNS
cord-001835-0s7ok4uw	1648	11	and	and	CC
cord-001835-0s7ok4uw	1648	12	used	use	VBD
cord-001835-0s7ok4uw	1648	13	different	different	JJ
cord-001835-0s7ok4uw	1648	14	algorithms	algorithm	NNS
cord-001835-0s7ok4uw	1648	15	.	.	.
cord-001835-0s7ok4uw	1649	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	1649	2	,	,	,
cord-001835-0s7ok4uw	1649	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1649	4	used	use	VBD
cord-001835-0s7ok4uw	1649	5	circular	circular	JJ
cord-001835-0s7ok4uw	1649	6	dichroism	dichroism	NN
cord-001835-0s7ok4uw	1649	7	in	in	IN
cord-001835-0s7ok4uw	1649	8	the	the	DT
cord-001835-0s7ok4uw	1649	9	UV	uv	NN
cord-001835-0s7ok4uw	1649	10	-	-	HYPH
cord-001835-0s7ok4uw	1649	11	far	far	JJ
cord-001835-0s7ok4uw	1649	12	region	region	NN
cord-001835-0s7ok4uw	1649	13	to	to	TO
cord-001835-0s7ok4uw	1649	14	determine	determine	VB
cord-001835-0s7ok4uw	1649	15	if	if	IN
cord-001835-0s7ok4uw	1649	16	there	there	EX
cord-001835-0s7ok4uw	1649	17	existed	exist	VBN
cord-001835-0s7ok4uw	1649	18	conformational	conformational	JJ
cord-001835-0s7ok4uw	1649	19	changes	change	NNS
cord-001835-0s7ok4uw	1649	20	upon	upon	IN
cord-001835-0s7ok4uw	1649	21	binding	bind	VBG
cord-001835-0s7ok4uw	1649	22	of	of	IN
cord-001835-0s7ok4uw	1649	23	the	the	DT
cord-001835-0s7ok4uw	1649	24	cyclodextrin	cyclodextrin	NN
cord-001835-0s7ok4uw	1649	25	molecules	molecule	NNS
cord-001835-0s7ok4uw	1649	26	to	to	IN
cord-001835-0s7ok4uw	1649	27	the	the	DT
cord-001835-0s7ok4uw	1649	28	different	different	JJ
cord-001835-0s7ok4uw	1649	29	tandem	tandem	NN
cord-001835-0s7ok4uw	1649	30	modules	module	NNS
cord-001835-0s7ok4uw	1649	31	.	.	.
cord-001835-0s7ok4uw	1650	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1650	2	could	could	MD
cord-001835-0s7ok4uw	1650	3	only	only	RB
cord-001835-0s7ok4uw	1650	4	observe	observe	VB
cord-001835-0s7ok4uw	1650	5	slight	slight	JJ
cord-001835-0s7ok4uw	1650	6	changes	change	NNS
cord-001835-0s7ok4uw	1650	7	in	in	IN
cord-001835-0s7ok4uw	1650	8	a	a	DT
cord-001835-0s7ok4uw	1650	9	positive	positive	JJ
cord-001835-0s7ok4uw	1650	10	band	band	NN
cord-001835-0s7ok4uw	1650	11	centered	center	VBN
cord-001835-0s7ok4uw	1650	12	around	around	IN
cord-001835-0s7ok4uw	1650	13	220	220	CD
cord-001835-0s7ok4uw	1650	14	-	-	SYM
cord-001835-0s7ok4uw	1650	15	240	240	CD
cord-001835-0s7ok4uw	1650	16	nm	nm	NN
cord-001835-0s7ok4uw	1650	17	,	,	,
cord-001835-0s7ok4uw	1650	18	which	which	WDT
cord-001835-0s7ok4uw	1650	19	has	have	VBZ
cord-001835-0s7ok4uw	1650	20	been	be	VBN
cord-001835-0s7ok4uw	1650	21	explained	explain	VBN
cord-001835-0s7ok4uw	1650	22	in	in	IN
cord-001835-0s7ok4uw	1650	23	terms	term	NNS
cord-001835-0s7ok4uw	1650	24	of	of	IN
cord-001835-0s7ok4uw	1650	25	p	p	NN
cord-001835-0s7ok4uw	1650	26	-	-	HYPH
cord-001835-0s7ok4uw	1650	27	p	p	NN
cord-001835-0s7ok4uw	1650	28	;	;	:
cord-001835-0s7ok4uw	1650	29	interactions	interaction	NNS
cord-001835-0s7ok4uw	1650	30	of	of	IN
cord-001835-0s7ok4uw	1650	31	the	the	DT
cord-001835-0s7ok4uw	1650	32	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	1650	33	residues	residue	NNS
cord-001835-0s7ok4uw	1650	34	at	at	IN
cord-001835-0s7ok4uw	1650	35	the	the	DT
cord-001835-0s7ok4uw	1650	36	binding	binding	NN
cord-001835-0s7ok4uw	1650	37	site	site	NN
cord-001835-0s7ok4uw	1650	38	.	.	.
cord-001835-0s7ok4uw	1651	1	These	these	DT
cord-001835-0s7ok4uw	1651	2	CBMs	cbm	NNS
cord-001835-0s7ok4uw	1651	3	have	have	VBP
cord-001835-0s7ok4uw	1651	4	been	be	VBN
cord-001835-0s7ok4uw	1651	5	used	use	VBN
cord-001835-0s7ok4uw	1651	6	as	as	IN
cord-001835-0s7ok4uw	1651	7	carriers	carrier	NNS
cord-001835-0s7ok4uw	1651	8	for	for	IN
cord-001835-0s7ok4uw	1651	9	in	in	IN
cord-001835-0s7ok4uw	1651	10	vivo	vivo	NN
cord-001835-0s7ok4uw	1651	11	vaccine	vaccine	NN
cord-001835-0s7ok4uw	1651	12	delivery	delivery	NN
cord-001835-0s7ok4uw	1651	13	and	and	CC
cord-001835-0s7ok4uw	1651	14	affinity	affinity	NN
cord-001835-0s7ok4uw	1651	15	tags	tag	NNS
cord-001835-0s7ok4uw	1651	16	.	.	.
cord-001835-0s7ok4uw	1652	1	The	the	DT
cord-001835-0s7ok4uw	1652	2	second	second	JJ
cord-001835-0s7ok4uw	1652	3	model	model	NN
cord-001835-0s7ok4uw	1652	4	is	be	VBZ
cord-001835-0s7ok4uw	1652	5	a	a	DT
cord-001835-0s7ok4uw	1652	6	hevein	hevein	NN
cord-001835-0s7ok4uw	1652	7	-	-	HYPH
cord-001835-0s7ok4uw	1652	8	like	like	JJ
cord-001835-0s7ok4uw	1652	9	CBM	CBM	NNP
cord-001835-0s7ok4uw	1652	10	of	of	IN
cord-001835-0s7ok4uw	1652	11	the	the	DT
cord-001835-0s7ok4uw	1652	12	family	family	NN
cord-001835-0s7ok4uw	1652	13	18	18	CD
cord-001835-0s7ok4uw	1652	14	present	present	JJ
cord-001835-0s7ok4uw	1652	15	in	in	IN
cord-001835-0s7ok4uw	1652	16	a	a	DT
cord-001835-0s7ok4uw	1652	17	chitinase	chitinase	NN
cord-001835-0s7ok4uw	1652	18	-	-	HYPH
cord-001835-0s7ok4uw	1652	19	like	like	JJ
cord-001835-0s7ok4uw	1652	20	protein	protein	NN
cord-001835-0s7ok4uw	1652	21	from	from	IN
cord-001835-0s7ok4uw	1652	22	Hevea	Hevea	NNP
cord-001835-0s7ok4uw	1652	23	brasiliensis	brasiliensis	NN
cord-001835-0s7ok4uw	1652	24	(	(	-LRB-
cord-001835-0s7ok4uw	1652	25	HbCBM18	HbCBM18	NNP
cord-001835-0s7ok4uw	1652	26	)	)	-RRB-
cord-001835-0s7ok4uw	1652	27	.	.	.
cord-001835-0s7ok4uw	1653	1	Hevein	Hevein	NNP
cord-001835-0s7ok4uw	1653	2	is	be	VBZ
cord-001835-0s7ok4uw	1653	3	a	a	DT
cord-001835-0s7ok4uw	1653	4	lectin	lectin	NN
cord-001835-0s7ok4uw	1653	5	from	from	IN
cord-001835-0s7ok4uw	1653	6	H.	h.	NN
cord-001835-0s7ok4uw	1653	7	brasiliensis	brasiliensis	NN
cord-001835-0s7ok4uw	1653	8	that	that	WDT
cord-001835-0s7ok4uw	1653	9	shows	show	VBZ
cord-001835-0s7ok4uw	1653	10	a	a	DT
cord-001835-0s7ok4uw	1653	11	63	63	CD
cord-001835-0s7ok4uw	1653	12	%	%	NN
cord-001835-0s7ok4uw	1653	13	identity	identity	NN
cord-001835-0s7ok4uw	1653	14	with	with	IN
cord-001835-0s7ok4uw	1653	15	HbCBM18	HbCBM18	NNP
cord-001835-0s7ok4uw	1653	16	.	.	.
cord-001835-0s7ok4uw	1654	1	These	these	DT
cord-001835-0s7ok4uw	1654	2	CMBs	cmb	NNS
cord-001835-0s7ok4uw	1654	3	are	be	VBP
cord-001835-0s7ok4uw	1654	4	connected	connect	VBN
cord-001835-0s7ok4uw	1654	5	to	to	IN
cord-001835-0s7ok4uw	1654	6	the	the	DT
cord-001835-0s7ok4uw	1654	7	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1654	8	domain	domain	NN
cord-001835-0s7ok4uw	1654	9	,	,	,
cord-001835-0s7ok4uw	1654	10	in	in	IN
cord-001835-0s7ok4uw	1654	11	proteins	protein	NNS
cord-001835-0s7ok4uw	1654	12	such	such	JJ
cord-001835-0s7ok4uw	1654	13	as	as	IN
cord-001835-0s7ok4uw	1654	14	chitinases	chitinase	NNS
cord-001835-0s7ok4uw	1654	15	,	,	,
cord-001835-0s7ok4uw	1654	16	by	by	IN
cord-001835-0s7ok4uw	1654	17	a	a	DT
cord-001835-0s7ok4uw	1654	18	linker	linker	NN
cord-001835-0s7ok4uw	1654	19	of	of	IN
cord-001835-0s7ok4uw	1654	20	approximately	approximately	RB
cord-001835-0s7ok4uw	1654	21	10	10	CD
cord-001835-0s7ok4uw	1654	22	residues	residue	NNS
cord-001835-0s7ok4uw	1654	23	.	.	.
cord-001835-0s7ok4uw	1655	1	In	in	IN
cord-001835-0s7ok4uw	1655	2	these	these	DT
cord-001835-0s7ok4uw	1655	3	experiments	experiment	NNS
cord-001835-0s7ok4uw	1655	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	1655	5	used	use	VBD
cord-001835-0s7ok4uw	1655	6	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1655	7	techniques	technique	NNS
cord-001835-0s7ok4uw	1655	8	to	to	TO
cord-001835-0s7ok4uw	1655	9	determine	determine	VB
cord-001835-0s7ok4uw	1655	10	the	the	DT
cord-001835-0s7ok4uw	1655	11	affinity	affinity	NN
cord-001835-0s7ok4uw	1655	12	constants	constant	NNS
cord-001835-0s7ok4uw	1655	13	for	for	IN
cord-001835-0s7ok4uw	1655	14	chitotriose	chitotriose	NNS
cord-001835-0s7ok4uw	1655	15	.	.	.
cord-001835-0s7ok4uw	1656	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1656	2	previously	previously	RB
cord-001835-0s7ok4uw	1656	3	reported	report	VBD
cord-001835-0s7ok4uw	1656	4	a	a	DT
cord-001835-0s7ok4uw	1656	5	Ka	Ka	NNP
cord-001835-0s7ok4uw	1656	6	5	5	CD
cord-001835-0s7ok4uw	1656	7	2.08x106	2.08x106	CD
cord-001835-0s7ok4uw	1656	8	M-1	M-1	NNP
cord-001835-0s7ok4uw	1656	9	when	when	WRB
cord-001835-0s7ok4uw	1656	10	using	use	VBG
cord-001835-0s7ok4uw	1656	11	a	a	DT
cord-001835-0s7ok4uw	1656	12	HbCBM18	HbCBM18	NNP
cord-001835-0s7ok4uw	1656	13	that	that	WDT
cord-001835-0s7ok4uw	1656	14	has	have	VBZ
cord-001835-0s7ok4uw	1656	15	a	a	DT
cord-001835-0s7ok4uw	1656	16	Met	Met	NNP
cord-001835-0s7ok4uw	1656	17	residue	residue	NN
cord-001835-0s7ok4uw	1656	18	at	at	IN
cord-001835-0s7ok4uw	1656	19	the	the	DT
cord-001835-0s7ok4uw	1656	20	Nterminal	Nterminal	NNP
cord-001835-0s7ok4uw	1656	21	region	region	NN
cord-001835-0s7ok4uw	1656	22	.	.	.
cord-001835-0s7ok4uw	1657	1	Besides	besides	IN
cord-001835-0s7ok4uw	1657	2	the	the	DT
cord-001835-0s7ok4uw	1657	3	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	1657	4	residues	residue	NNS
cord-001835-0s7ok4uw	1657	5	at	at	IN
cord-001835-0s7ok4uw	1657	6	the	the	DT
cord-001835-0s7ok4uw	1657	7	binding	binding	NN
cord-001835-0s7ok4uw	1657	8	site	site	NN
cord-001835-0s7ok4uw	1657	9	,	,	,
cord-001835-0s7ok4uw	1657	10	the	the	DT
cord-001835-0s7ok4uw	1657	11	Met	Met	NNP
cord-001835-0s7ok4uw	1657	12	residue	residue	NN
cord-001835-0s7ok4uw	1657	13	also	also	RB
cord-001835-0s7ok4uw	1657	14	interacts	interact	VBZ
cord-001835-0s7ok4uw	1657	15	with	with	IN
cord-001835-0s7ok4uw	1657	16	the	the	DT
cord-001835-0s7ok4uw	1657	17	ligand	ligand	NN
cord-001835-0s7ok4uw	1657	18	,	,	,
cord-001835-0s7ok4uw	1657	19	as	as	IN
cord-001835-0s7ok4uw	1657	20	determined	determine	VBN
cord-001835-0s7ok4uw	1657	21	using	use	VBG
cord-001835-0s7ok4uw	1657	22	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	1657	23	and	and	CC
cord-001835-0s7ok4uw	1657	24	docking	docking	NN
cord-001835-0s7ok4uw	1657	25	techniques	technique	NNS
cord-001835-0s7ok4uw	1657	26	.	.	.
cord-001835-0s7ok4uw	1658	1	The	the	DT
cord-001835-0s7ok4uw	1658	2	mutant	mutant	JJ
cord-001835-0s7ok4uw	1658	3	HbCBM18-R5W	hbcbm18-r5w	NN
cord-001835-0s7ok4uw	1658	4	that	that	WDT
cord-001835-0s7ok4uw	1658	5	does	do	VBZ
cord-001835-0s7ok4uw	1658	6	not	not	RB
cord-001835-0s7ok4uw	1658	7	have	have	VB
cord-001835-0s7ok4uw	1658	8	the	the	DT
cord-001835-0s7ok4uw	1658	9	Met	Met	NNP
cord-001835-0s7ok4uw	1658	10	residue	residue	NN
cord-001835-0s7ok4uw	1658	11	showed	show	VBD
cord-001835-0s7ok4uw	1658	12	a	a	DT
cord-001835-0s7ok4uw	1658	13	Ka	Ka	NNP
cord-001835-0s7ok4uw	1658	14	of	of	IN
cord-001835-0s7ok4uw	1658	15	2.8x104	2.8x104	CD
cord-001835-0s7ok4uw	1658	16	M-1	M-1	NNP
cord-001835-0s7ok4uw	1658	17	with	with	IN
cord-001835-0s7ok4uw	1658	18	chitotriose	chitotriose	NNS
cord-001835-0s7ok4uw	1658	19	,	,	,
cord-001835-0s7ok4uw	1658	20	similar	similar	JJ
cord-001835-0s7ok4uw	1658	21	to	to	IN
cord-001835-0s7ok4uw	1658	22	the	the	DT
cord-001835-0s7ok4uw	1658	23	value	value	NN
cord-001835-0s7ok4uw	1658	24	reported	report	VBN
cord-001835-0s7ok4uw	1658	25	for	for	IN
cord-001835-0s7ok4uw	1658	26	hevein	hevein	NNP
cord-001835-0s7ok4uw	1658	27	using	use	VBG
cord-001835-0s7ok4uw	1658	28	ITC	ITC	NNP
cord-001835-0s7ok4uw	1658	29	(	(	-LRB-
cord-001835-0s7ok4uw	1658	30	Ka	Ka	NNP
cord-001835-0s7ok4uw	1658	31	1.42x104	1.42x104	CD
cord-001835-0s7ok4uw	1658	32	M-1	M-1	NNP
cord-001835-0s7ok4uw	1658	33	)	)	-RRB-
cord-001835-0s7ok4uw	1658	34	.	.	.
cord-001835-0s7ok4uw	1659	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	1659	2	,	,	,
cord-001835-0s7ok4uw	1659	3	there	there	EX
cord-001835-0s7ok4uw	1659	4	exists	exist	VBZ
cord-001835-0s7ok4uw	1659	5	an	an	DT
cord-001835-0s7ok4uw	1659	6	isoform	isoform	NN
cord-001835-0s7ok4uw	1659	7	of	of	IN
cord-001835-0s7ok4uw	1659	8	the	the	DT
cord-001835-0s7ok4uw	1659	9	HbCBM18	HbCBM18	NNP
cord-001835-0s7ok4uw	1659	10	that	that	WDT
cord-001835-0s7ok4uw	1659	11	has	have	VBZ
cord-001835-0s7ok4uw	1659	12	a	a	DT
cord-001835-0s7ok4uw	1659	13	connector	connector	NN
cord-001835-0s7ok4uw	1659	14	between	between	IN
cord-001835-0s7ok4uw	1659	15	one	one	CD
cord-001835-0s7ok4uw	1659	16	CBM18	CBM18	NNP
cord-001835-0s7ok4uw	1659	17	and	and	CC
cord-001835-0s7ok4uw	1659	18	a	a	DT
cord-001835-0s7ok4uw	1659	19	half	half	NN
cord-001835-0s7ok4uw	1659	20	CBM18	CBM18	NNP
cord-001835-0s7ok4uw	1659	21	(	(	-LRB-
cord-001835-0s7ok4uw	1659	22	1.5xHbCBM18	1.5xHbCBM18	NNP
cord-001835-0s7ok4uw	1659	23	)	)	-RRB-
cord-001835-0s7ok4uw	1659	24	.	.	.
cord-001835-0s7ok4uw	1660	1	This	this	DT
cord-001835-0s7ok4uw	1660	2	protein	protein	NN
cord-001835-0s7ok4uw	1660	3	has	have	VBZ
cord-001835-0s7ok4uw	1660	4	a	a	DT
cord-001835-0s7ok4uw	1660	5	Ka	Ka	NNP
cord-001835-0s7ok4uw	1660	6	of	of	IN
cord-001835-0s7ok4uw	1660	7	6.7x105	6.7x105	CD
cord-001835-0s7ok4uw	1660	8	M-1	M-1	NNP
cord-001835-0s7ok4uw	1660	9	with	with	IN
cord-001835-0s7ok4uw	1660	10	the	the	DT
cord-001835-0s7ok4uw	1660	11	same	same	JJ
cord-001835-0s7ok4uw	1660	12	ligand	ligand	NN
cord-001835-0s7ok4uw	1660	13	.	.	.
cord-001835-0s7ok4uw	1661	1	Initiating	initiate	VBG
cord-001835-0s7ok4uw	1661	2	vesicle	vesicle	NN
cord-001835-0s7ok4uw	1661	3	formation	formation	NN
cord-001835-0s7ok4uw	1661	4	at	at	IN
cord-001835-0s7ok4uw	1661	5	the	the	DT
cord-001835-0s7ok4uw	1661	6	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	1661	7	complex	complex	NN
cord-001835-0s7ok4uw	1661	8	:	:	:
cord-001835-0s7ok4uw	1661	9	auto	auto	NN
cord-001835-0s7ok4uw	1661	10	-	-	HYPH
cord-001835-0s7ok4uw	1661	11	regulation	regulation	NN
cord-001835-0s7ok4uw	1661	12	and	and	CC
cord-001835-0s7ok4uw	1661	13	protein	protein	NN
cord-001835-0s7ok4uw	1661	14	interactions	interaction	NNS
cord-001835-0s7ok4uw	1661	15	govern	govern	VBP
cord-001835-0s7ok4uw	1661	16	the	the	DT
cord-001835-0s7ok4uw	1661	17	Arf	Arf	NNP
cord-001835-0s7ok4uw	1661	18	-	-	HYPH
cord-001835-0s7ok4uw	1661	19	GEFs	GEFs	NNP
cord-001835-0s7ok4uw	1661	20	Gea1	Gea1	NNP
cord-001835-0s7ok4uw	1661	21	and	and	CC
cord-001835-0s7ok4uw	1661	22	Gea2	Gea2	NNP
cord-001835-0s7ok4uw	1661	23	Margaret	Margaret	NNP
cord-001835-0s7ok4uw	1661	24	Gustafson	Gustafson	NNP
cord-001835-0s7ok4uw	1661	25	1	1	CD
cord-001835-0s7ok4uw	1661	26	,	,	,
cord-001835-0s7ok4uw	1661	27	J.	J.	NNP
cord-001835-0s7ok4uw	1661	28	Chris	Chris	NNP
cord-001835-0s7ok4uw	1661	29	Fromme	Fromme	NNP
cord-001835-0s7ok4uw	1661	30	1	1	CD
cord-001835-0s7ok4uw	1661	31	1	1	CD
cord-001835-0s7ok4uw	1661	32	Molecular	molecular	JJ
cord-001835-0s7ok4uw	1661	33	decision	decision	NN
cord-001835-0s7ok4uw	1661	34	-	-	HYPH
cord-001835-0s7ok4uw	1661	35	makers	maker	NNS
cord-001835-0s7ok4uw	1661	36	play	play	VBP
cord-001835-0s7ok4uw	1661	37	critical	critical	JJ
cord-001835-0s7ok4uw	1661	38	roles	role	NNS
cord-001835-0s7ok4uw	1661	39	in	in	IN
cord-001835-0s7ok4uw	1661	40	the	the	DT
cord-001835-0s7ok4uw	1661	41	effort	effort	NN
cord-001835-0s7ok4uw	1661	42	to	to	TO
cord-001835-0s7ok4uw	1661	43	maintain	maintain	VB
cord-001835-0s7ok4uw	1661	44	efficient	efficient	JJ
cord-001835-0s7ok4uw	1661	45	and	and	CC
cord-001835-0s7ok4uw	1661	46	accurate	accurate	JJ
cord-001835-0s7ok4uw	1661	47	cellular	cellular	JJ
cord-001835-0s7ok4uw	1661	48	functions	function	NNS
cord-001835-0s7ok4uw	1661	49	.	.	.
cord-001835-0s7ok4uw	1662	1	In	in	IN
cord-001835-0s7ok4uw	1662	2	the	the	DT
cord-001835-0s7ok4uw	1662	3	case	case	NN
cord-001835-0s7ok4uw	1662	4	of	of	IN
cord-001835-0s7ok4uw	1662	5	vesicular	vesicular	JJ
cord-001835-0s7ok4uw	1662	6	traffic	traffic	NN
cord-001835-0s7ok4uw	1662	7	at	at	IN
cord-001835-0s7ok4uw	1662	8	the	the	DT
cord-001835-0s7ok4uw	1662	9	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	1662	10	complex	complex	NN
cord-001835-0s7ok4uw	1662	11	,	,	,
cord-001835-0s7ok4uw	1662	12	the	the	DT
cord-001835-0s7ok4uw	1662	13	decision	decision	NN
cord-001835-0s7ok4uw	1662	14	to	to	TO
cord-001835-0s7ok4uw	1662	15	initiate	initiate	VB
cord-001835-0s7ok4uw	1662	16	vesicle	vesicle	NN
cord-001835-0s7ok4uw	1662	17	formation	formation	NN
cord-001835-0s7ok4uw	1662	18	is	be	VBZ
cord-001835-0s7ok4uw	1662	19	made	make	VBN
cord-001835-0s7ok4uw	1662	20	by	by	IN
cord-001835-0s7ok4uw	1662	21	a	a	DT
cord-001835-0s7ok4uw	1662	22	set	set	NN
cord-001835-0s7ok4uw	1662	23	of	of	IN
cord-001835-0s7ok4uw	1662	24	guanine	guanine	NN
cord-001835-0s7ok4uw	1662	25	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	1662	26	exchange	exchange	NN
cord-001835-0s7ok4uw	1662	27	factors	factor	NNS
cord-001835-0s7ok4uw	1662	28	(	(	-LRB-
cord-001835-0s7ok4uw	1662	29	GEFs	GEFs	NNP
cord-001835-0s7ok4uw	1662	30	)	)	-RRB-
cord-001835-0s7ok4uw	1662	31	that	that	WDT
cord-001835-0s7ok4uw	1662	32	activate	activate	VBP
cord-001835-0s7ok4uw	1662	33	the	the	DT
cord-001835-0s7ok4uw	1662	34	small	small	JJ
cord-001835-0s7ok4uw	1662	35	GTPase	GTPase	NNP
cord-001835-0s7ok4uw	1662	36	Arf1	Arf1	NNP
cord-001835-0s7ok4uw	1662	37	,	,	,
cord-001835-0s7ok4uw	1662	38	which	which	WDT
cord-001835-0s7ok4uw	1662	39	is	be	VBZ
cord-001835-0s7ok4uw	1662	40	the	the	DT
cord-001835-0s7ok4uw	1662	41	master	master	NN
cord-001835-0s7ok4uw	1662	42	controller	controller	NN
cord-001835-0s7ok4uw	1662	43	for	for	IN
cord-001835-0s7ok4uw	1662	44	the	the	DT
cord-001835-0s7ok4uw	1662	45	recruitment	recruitment	NN
cord-001835-0s7ok4uw	1662	46	of	of	IN
cord-001835-0s7ok4uw	1662	47	cargos	cargo	NNS
cord-001835-0s7ok4uw	1662	48	and	and	CC
cord-001835-0s7ok4uw	1662	49	coat	coat	NN
cord-001835-0s7ok4uw	1662	50	proteins	protein	NNS
cord-001835-0s7ok4uw	1662	51	.	.	.
cord-001835-0s7ok4uw	1663	1	Saccharomyces	saccharomyce	NNS
cord-001835-0s7ok4uw	1663	2	cerevisiae	cerevisiae	NNS
cord-001835-0s7ok4uw	1663	3	possess	possess	VBP
cord-001835-0s7ok4uw	1663	4	three	three	CD
cord-001835-0s7ok4uw	1663	5	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	1663	6	Arf	Arf	NNP
cord-001835-0s7ok4uw	1663	7	-	-	HYPH
cord-001835-0s7ok4uw	1663	8	GEFs	GEFs	NNP
cord-001835-0s7ok4uw	1663	9	,	,	,
cord-001835-0s7ok4uw	1663	10	Gea1	Gea1	NNP
cord-001835-0s7ok4uw	1663	11	,	,	,
cord-001835-0s7ok4uw	1663	12	Gea2	Gea2	NNP
cord-001835-0s7ok4uw	1663	13	,	,	,
cord-001835-0s7ok4uw	1663	14	and	and	CC
cord-001835-0s7ok4uw	1663	15	Sec7	Sec7	NNP
cord-001835-0s7ok4uw	1663	16	,	,	,
cord-001835-0s7ok4uw	1663	17	which	which	WDT
cord-001835-0s7ok4uw	1663	18	work	work	VBP
cord-001835-0s7ok4uw	1663	19	at	at	IN
cord-001835-0s7ok4uw	1663	20	distinct	distinct	JJ
cord-001835-0s7ok4uw	1663	21	sub	sub	NN
cord-001835-0s7ok4uw	1663	22	-	-	HYPH
cord-001835-0s7ok4uw	1663	23	compartments	compartment	NNS
cord-001835-0s7ok4uw	1663	24	of	of	IN
cord-001835-0s7ok4uw	1663	25	the	the	DT
cord-001835-0s7ok4uw	1663	26	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	1663	27	to	to	TO
cord-001835-0s7ok4uw	1663	28	activate	activate	VB
cord-001835-0s7ok4uw	1663	29	Arf1	Arf1	NNP
cord-001835-0s7ok4uw	1663	30	only	only	RB
cord-001835-0s7ok4uw	1663	31	when	when	WRB
cord-001835-0s7ok4uw	1663	32	and	and	CC
cord-001835-0s7ok4uw	1663	33	where	where	WRB
cord-001835-0s7ok4uw	1663	34	appropriate	appropriate	JJ
cord-001835-0s7ok4uw	1663	35	.	.	.
cord-001835-0s7ok4uw	1664	1	In	in	IN
cord-001835-0s7ok4uw	1664	2	the	the	DT
cord-001835-0s7ok4uw	1664	3	case	case	NN
cord-001835-0s7ok4uw	1664	4	of	of	IN
cord-001835-0s7ok4uw	1664	5	Sec7	Sec7	NNP
cord-001835-0s7ok4uw	1664	6	at	at	IN
cord-001835-0s7ok4uw	1664	7	the	the	DT
cord-001835-0s7ok4uw	1664	8	trans	trans	NNP
cord-001835-0s7ok4uw	1664	9	-	-	NNP
cord-001835-0s7ok4uw	1664	10	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	1664	11	network	network	NN
cord-001835-0s7ok4uw	1664	12	(	(	-LRB-
cord-001835-0s7ok4uw	1664	13	TGN	TGN	NNP
cord-001835-0s7ok4uw	1664	14	)	)	-RRB-
cord-001835-0s7ok4uw	1664	15	,	,	,
cord-001835-0s7ok4uw	1664	16	this	this	DT
cord-001835-0s7ok4uw	1664	17	requires	require	VBZ
cord-001835-0s7ok4uw	1664	18	a	a	DT
cord-001835-0s7ok4uw	1664	19	positive	positive	JJ
cord-001835-0s7ok4uw	1664	20	feedback	feedback	NN
cord-001835-0s7ok4uw	1664	21	loop	loop	NN
cord-001835-0s7ok4uw	1664	22	in	in	IN
cord-001835-0s7ok4uw	1664	23	which	which	WDT
cord-001835-0s7ok4uw	1664	24	active	active	JJ
cord-001835-0s7ok4uw	1664	25	Arf1	Arf1	NNP
cord-001835-0s7ok4uw	1664	26	relieves	relieve	VBZ
cord-001835-0s7ok4uw	1664	27	autoinhibition	autoinhibition	NN
cord-001835-0s7ok4uw	1664	28	of	of	IN
cord-001835-0s7ok4uw	1664	29	Sec7	Sec7	NNP
cord-001835-0s7ok4uw	1664	30	,	,	,
cord-001835-0s7ok4uw	1664	31	as	as	RB
cord-001835-0s7ok4uw	1664	32	well	well	RB
cord-001835-0s7ok4uw	1664	33	as	as	IN
cord-001835-0s7ok4uw	1664	34	recruitment	recruitment	NN
cord-001835-0s7ok4uw	1664	35	to	to	IN
cord-001835-0s7ok4uw	1664	36	the	the	DT
cord-001835-0s7ok4uw	1664	37	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	1664	38	membrane	membrane	NN
cord-001835-0s7ok4uw	1664	39	and	and	CC
cord-001835-0s7ok4uw	1664	40	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1664	41	stimulation	stimulation	NN
cord-001835-0s7ok4uw	1664	42	by	by	IN
cord-001835-0s7ok4uw	1664	43	signaling	signal	VBG
cord-001835-0s7ok4uw	1664	44	Rab	Rab	NNP
cord-001835-0s7ok4uw	1664	45	GTPases	gtpase	NNS
cord-001835-0s7ok4uw	1664	46	.	.	.
cord-001835-0s7ok4uw	1665	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1665	2	know	know	VBP
cord-001835-0s7ok4uw	1665	3	far	far	RB
cord-001835-0s7ok4uw	1665	4	less	less	JJR
cord-001835-0s7ok4uw	1665	5	about	about	IN
cord-001835-0s7ok4uw	1665	6	the	the	DT
cord-001835-0s7ok4uw	1665	7	decisionmaking	decisionmaking	NN
cord-001835-0s7ok4uw	1665	8	process	process	NN
cord-001835-0s7ok4uw	1665	9	for	for	IN
cord-001835-0s7ok4uw	1665	10	Gea1	Gea1	NNP
cord-001835-0s7ok4uw	1665	11	and	and	CC
cord-001835-0s7ok4uw	1665	12	Gea2	Gea2	NNP
cord-001835-0s7ok4uw	1665	13	,	,	,
cord-001835-0s7ok4uw	1665	14	which	which	WDT
cord-001835-0s7ok4uw	1665	15	are	be	VBP
cord-001835-0s7ok4uw	1665	16	responsible	responsible	JJ
cord-001835-0s7ok4uw	1665	17	for	for	IN
cord-001835-0s7ok4uw	1665	18	retrograde	retrograde	JJ
cord-001835-0s7ok4uw	1665	19	traffic	traffic	NN
cord-001835-0s7ok4uw	1665	20	within	within	IN
cord-001835-0s7ok4uw	1665	21	the	the	DT
cord-001835-0s7ok4uw	1665	22	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	1665	23	and	and	CC
cord-001835-0s7ok4uw	1665	24	to	to	IN
cord-001835-0s7ok4uw	1665	25	the	the	DT
cord-001835-0s7ok4uw	1665	26	endoplasmic	endoplasmic	NN
cord-001835-0s7ok4uw	1665	27	reticulum	reticulum	NN
cord-001835-0s7ok4uw	1665	28	.	.	.
cord-001835-0s7ok4uw	1666	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	1666	2	have	have	VBP
cord-001835-0s7ok4uw	1666	3	found	find	VBN
cord-001835-0s7ok4uw	1666	4	that	that	IN
cord-001835-0s7ok4uw	1666	5	both	both	DT
cord-001835-0s7ok4uw	1666	6	Gea1	Gea1	NNP
cord-001835-0s7ok4uw	1666	7	and	and	CC
cord-001835-0s7ok4uw	1666	8	Gea2	Gea2	NNP
cord-001835-0s7ok4uw	1666	9	can	can	MD
cord-001835-0s7ok4uw	1666	10	bind	bind	VB
cord-001835-0s7ok4uw	1666	11	membranes	membrane	NNS
cord-001835-0s7ok4uw	1666	12	weakly	weakly	RB
cord-001835-0s7ok4uw	1666	13	in	in	IN
cord-001835-0s7ok4uw	1666	14	vitro	vitro	FW
cord-001835-0s7ok4uw	1666	15	,	,	,
cord-001835-0s7ok4uw	1666	16	an	an	DT
cord-001835-0s7ok4uw	1666	17	ability	ability	NN
cord-001835-0s7ok4uw	1666	18	which	which	WDT
cord-001835-0s7ok4uw	1666	19	is	be	VBZ
cord-001835-0s7ok4uw	1666	20	counteracted	counteract	VBN
cord-001835-0s7ok4uw	1666	21	by	by	IN
cord-001835-0s7ok4uw	1666	22	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1666	23	C	c	NN
cord-001835-0s7ok4uw	1666	24	-	-	HYPH
cord-001835-0s7ok4uw	1666	25	terminal	terminal	NN
cord-001835-0s7ok4uw	1666	26	HDS3	HDS3	NNP
cord-001835-0s7ok4uw	1666	27	domains	domain	NNS
cord-001835-0s7ok4uw	1666	28	.	.	.
cord-001835-0s7ok4uw	1667	1	In	in	IN
cord-001835-0s7ok4uw	1667	2	addition	addition	NN
cord-001835-0s7ok4uw	1667	3	,	,	,
cord-001835-0s7ok4uw	1667	4	I	-PRON-	PRP
cord-001835-0s7ok4uw	1667	5	have	have	VBP
cord-001835-0s7ok4uw	1667	6	discovered	discover	VBN
cord-001835-0s7ok4uw	1667	7	membrane	membrane	NN
cord-001835-0s7ok4uw	1667	8	recruitment	recruitment	NN
cord-001835-0s7ok4uw	1667	9	in	in	IN
cord-001835-0s7ok4uw	1667	10	vitro	vitro	FW
cord-001835-0s7ok4uw	1667	11	is	be	VBZ
cord-001835-0s7ok4uw	1667	12	aided	aid	VBN
cord-001835-0s7ok4uw	1667	13	by	by	IN
cord-001835-0s7ok4uw	1667	14	the	the	DT
cord-001835-0s7ok4uw	1667	15	Rab	Rab	NNP
cord-001835-0s7ok4uw	1667	16	GTPase	GTPase	NNP
cord-001835-0s7ok4uw	1667	17	Ypt1	Ypt1	NNP
cord-001835-0s7ok4uw	1667	18	.	.	.
cord-001835-0s7ok4uw	1668	1	However	however	RB
cord-001835-0s7ok4uw	1668	2	,	,	,
cord-001835-0s7ok4uw	1668	3	these	these	DT
cord-001835-0s7ok4uw	1668	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	1668	5	can	can	MD
cord-001835-0s7ok4uw	1668	6	not	not	RB
cord-001835-0s7ok4uw	1668	7	fully	fully	RB
cord-001835-0s7ok4uw	1668	8	explain	explain	VB
cord-001835-0s7ok4uw	1668	9	the	the	DT
cord-001835-0s7ok4uw	1668	10	distinct	distinct	JJ
cord-001835-0s7ok4uw	1668	11	localization	localization	NN
cord-001835-0s7ok4uw	1668	12	patterns	pattern	NNS
cord-001835-0s7ok4uw	1668	13	of	of	IN
cord-001835-0s7ok4uw	1668	14	Gea1	Gea1	NNP
cord-001835-0s7ok4uw	1668	15	,	,	,
cord-001835-0s7ok4uw	1668	16	Gea2	Gea2	NNP
cord-001835-0s7ok4uw	1668	17	,	,	,
cord-001835-0s7ok4uw	1668	18	and	and	CC
cord-001835-0s7ok4uw	1668	19	Sec7	Sec7	NNP
cord-001835-0s7ok4uw	1668	20	,	,	,
cord-001835-0s7ok4uw	1668	21	as	as	IN
cord-001835-0s7ok4uw	1668	22	all	all	DT
cord-001835-0s7ok4uw	1668	23	three	three	CD
cord-001835-0s7ok4uw	1668	24	have	have	VBP
cord-001835-0s7ok4uw	1668	25	been	be	VBN
cord-001835-0s7ok4uw	1668	26	shown	show	VBN
cord-001835-0s7ok4uw	1668	27	to	to	TO
cord-001835-0s7ok4uw	1668	28	be	be	VB
cord-001835-0s7ok4uw	1668	29	recruited	recruit	VBN
cord-001835-0s7ok4uw	1668	30	by	by	IN
cord-001835-0s7ok4uw	1668	31	Ypt1	Ypt1	NNP
cord-001835-0s7ok4uw	1668	32	,	,	,
cord-001835-0s7ok4uw	1668	33	which	which	WDT
cord-001835-0s7ok4uw	1668	34	is	be	VBZ
cord-001835-0s7ok4uw	1668	35	found	find	VBN
cord-001835-0s7ok4uw	1668	36	throughout	throughout	IN
cord-001835-0s7ok4uw	1668	37	the	the	DT
cord-001835-0s7ok4uw	1668	38	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	1668	39	.	.	.
cord-001835-0s7ok4uw	1669	1	My	-PRON-	PRP$
cord-001835-0s7ok4uw	1669	2	work	work	NN
cord-001835-0s7ok4uw	1669	3	has	have	VBZ
cord-001835-0s7ok4uw	1669	4	revealed	reveal	VBN
cord-001835-0s7ok4uw	1669	5	that	that	IN
cord-001835-0s7ok4uw	1669	6	in	in	IN
cord-001835-0s7ok4uw	1669	7	addition	addition	NN
cord-001835-0s7ok4uw	1669	8	to	to	IN
cord-001835-0s7ok4uw	1669	9	the	the	DT
cord-001835-0s7ok4uw	1669	10	well	well	RB
cord-001835-0s7ok4uw	1669	11	-	-	HYPH
cord-001835-0s7ok4uw	1669	12	established	establish	VBN
cord-001835-0s7ok4uw	1669	13	distinct	distinct	JJ
cord-001835-0s7ok4uw	1669	14	localization	localization	NN
cord-001835-0s7ok4uw	1669	15	from	from	IN
cord-001835-0s7ok4uw	1669	16	Sec7	Sec7	NNP
cord-001835-0s7ok4uw	1669	17	,	,	,
cord-001835-0s7ok4uw	1669	18	Gea1	Gea1	NNP
cord-001835-0s7ok4uw	1669	19	also	also	RB
cord-001835-0s7ok4uw	1669	20	occupies	occupy	VBZ
cord-001835-0s7ok4uw	1669	21	different	different	JJ
cord-001835-0s7ok4uw	1669	22	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	1669	23	compartments	compartment	NNS
cord-001835-0s7ok4uw	1669	24	from	from	IN
cord-001835-0s7ok4uw	1669	25	Gea2	Gea2	NNP
cord-001835-0s7ok4uw	1669	26	,	,	,
cord-001835-0s7ok4uw	1669	27	so	so	RB
cord-001835-0s7ok4uw	1669	28	specific	specific	JJ
cord-001835-0s7ok4uw	1669	29	signals	signal	NNS
cord-001835-0s7ok4uw	1669	30	must	must	MD
cord-001835-0s7ok4uw	1669	31	exist	exist	VB
cord-001835-0s7ok4uw	1669	32	which	which	WDT
cord-001835-0s7ok4uw	1669	33	help	help	VBP
cord-001835-0s7ok4uw	1669	34	the	the	DT
cord-001835-0s7ok4uw	1669	35	GEFs	GEFs	NNPS
cord-001835-0s7ok4uw	1669	36	decide	decide	VB
cord-001835-0s7ok4uw	1669	37	where	where	WRB
cord-001835-0s7ok4uw	1669	38	to	to	TO
cord-001835-0s7ok4uw	1669	39	go	go	VB
cord-001835-0s7ok4uw	1669	40	.	.	.
cord-001835-0s7ok4uw	1670	1	My	-PRON-	PRP$
cord-001835-0s7ok4uw	1670	2	current	current	JJ
cord-001835-0s7ok4uw	1670	3	efforts	effort	NNS
cord-001835-0s7ok4uw	1670	4	focus	focus	VBP
cord-001835-0s7ok4uw	1670	5	on	on	IN
cord-001835-0s7ok4uw	1670	6	understanding	understand	VBG
cord-001835-0s7ok4uw	1670	7	the	the	DT
cord-001835-0s7ok4uw	1670	8	roles	role	NNS
cord-001835-0s7ok4uw	1670	9	of	of	IN
cord-001835-0s7ok4uw	1670	10	the	the	DT
cord-001835-0s7ok4uw	1670	11	other	other	JJ
cord-001835-0s7ok4uw	1670	12	domains	domain	NNS
cord-001835-0s7ok4uw	1670	13	of	of	IN
cord-001835-0s7ok4uw	1670	14	Gea1	Gea1	NNP
cord-001835-0s7ok4uw	1670	15	and	and	CC
cord-001835-0s7ok4uw	1670	16	Gea2	Gea2	NNP
cord-001835-0s7ok4uw	1670	17	,	,	,
cord-001835-0s7ok4uw	1670	18	identifying	identify	VBG
cord-001835-0s7ok4uw	1670	19	the	the	DT
cord-001835-0s7ok4uw	1670	20	signals	signal	NNS
cord-001835-0s7ok4uw	1670	21	which	which	WDT
cord-001835-0s7ok4uw	1670	22	send	send	VBP
cord-001835-0s7ok4uw	1670	23	them	-PRON-	PRP
cord-001835-0s7ok4uw	1670	24	to	to	IN
cord-001835-0s7ok4uw	1670	25	different	different	JJ
cord-001835-0s7ok4uw	1670	26	parts	part	NNS
cord-001835-0s7ok4uw	1670	27	of	of	IN
cord-001835-0s7ok4uw	1670	28	the	the	DT
cord-001835-0s7ok4uw	1670	29	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	1670	30	,	,	,
cord-001835-0s7ok4uw	1670	31	and	and	CC
cord-001835-0s7ok4uw	1670	32	unraveling	unravel	VBG
cord-001835-0s7ok4uw	1670	33	the	the	DT
cord-001835-0s7ok4uw	1670	34	different	different	JJ
cord-001835-0s7ok4uw	1670	35	roles	role	NNS
cord-001835-0s7ok4uw	1670	36	they	-PRON-	PRP
cord-001835-0s7ok4uw	1670	37	play	play	VBP
cord-001835-0s7ok4uw	1670	38	in	in	IN
cord-001835-0s7ok4uw	1670	39	vesicle	vesicle	NN
cord-001835-0s7ok4uw	1670	40	trafficking	traffic	VBG
cord-001835-0s7ok4uw	1670	41	pathways	pathway	NNS
cord-001835-0s7ok4uw	1670	42	.	.	.
cord-001835-0s7ok4uw	1671	1	Sequence	sequence	NN
cord-001835-0s7ok4uw	1671	2	variation	variation	NN
cord-001835-0s7ok4uw	1671	3	in	in	IN
cord-001835-0s7ok4uw	1671	4	Archaea	Archaea	NNP
cord-001835-0s7ok4uw	1671	5	through	through	IN
cord-001835-0s7ok4uw	1671	6	diversity	diversity	NN
cord-001835-0s7ok4uw	1671	7	-	-	HYPH
cord-001835-0s7ok4uw	1671	8	generating	generate	VBG
cord-001835-0s7ok4uw	1671	9	retroelements	retroelement	NNS
cord-001835-0s7ok4uw	1671	10	Sumit	Sumit	NNP
cord-001835-0s7ok4uw	1671	11	Handa	Handa	NNP
cord-001835-0s7ok4uw	1671	12	1	1	CD
cord-001835-0s7ok4uw	1671	13	,	,	,
cord-001835-0s7ok4uw	1671	14	Blair	Blair	NNP
cord-001835-0s7ok4uw	1671	15	G	G	NNP
cord-001835-0s7ok4uw	1671	16	Paul	Paul	NNP
cord-001835-0s7ok4uw	1671	17	2	2	CD
cord-001835-0s7ok4uw	1671	18	,	,	,
cord-001835-0s7ok4uw	1671	19	Kharissa	Kharissa	NNP
cord-001835-0s7ok4uw	1671	20	L	L	NNP
cord-001835-0s7ok4uw	1671	21	Shaw	Shaw	NNP
cord-001835-0s7ok4uw	1671	22	1	1	CD
cord-001835-0s7ok4uw	1671	23	,	,	,
cord-001835-0s7ok4uw	1671	24	David	David	NNP
cord-001835-0s7ok4uw	1671	25	L	L	NNP
cord-001835-0s7ok4uw	1671	26	Valentine	Valentine	NNP
cord-001835-0s7ok4uw	1671	27	2	2	CD
cord-001835-0s7ok4uw	1671	28	,	,	,
cord-001835-0s7ok4uw	1671	29	Partho	Partho	NNP
cord-001835-0s7ok4uw	1671	30	Ghosh	Ghosh	NNP
cord-001835-0s7ok4uw	1671	31	1	1	CD
cord-001835-0s7ok4uw	1671	32	1	1	CD
cord-001835-0s7ok4uw	1671	33	Department	Department	NNP
cord-001835-0s7ok4uw	1671	34	of	of	IN
cord-001835-0s7ok4uw	1671	35	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	1671	36	and	and	CC
cord-001835-0s7ok4uw	1671	37	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	1671	38	,	,	,
cord-001835-0s7ok4uw	1671	39	University	University	NNP
cord-001835-0s7ok4uw	1671	40	of	of	IN
cord-001835-0s7ok4uw	1671	41	California	California	NNP
cord-001835-0s7ok4uw	1671	42	San	San	NNP
cord-001835-0s7ok4uw	1671	43	Diego	Diego	NNP
cord-001835-0s7ok4uw	1671	44	,	,	,
cord-001835-0s7ok4uw	1672	1	2	2	LS
cord-001835-0s7ok4uw	1672	2	Marine	Marine	NNP
cord-001835-0s7ok4uw	1672	3	Science	Science	NNP
cord-001835-0s7ok4uw	1672	4	Institute	Institute	NNP
cord-001835-0s7ok4uw	1672	5	,	,	,
cord-001835-0s7ok4uw	1672	6	University	University	NNP
cord-001835-0s7ok4uw	1672	7	of	of	IN
cord-001835-0s7ok4uw	1672	8	California	California	NNP
cord-001835-0s7ok4uw	1672	9	Protein	Protein	NNP
cord-001835-0s7ok4uw	1672	10	diversification	diversification	NN
cord-001835-0s7ok4uw	1672	11	is	be	VBZ
cord-001835-0s7ok4uw	1672	12	an	an	DT
cord-001835-0s7ok4uw	1672	13	essential	essential	JJ
cord-001835-0s7ok4uw	1672	14	tool	tool	NN
cord-001835-0s7ok4uw	1672	15	for	for	IN
cord-001835-0s7ok4uw	1672	16	the	the	DT
cord-001835-0s7ok4uw	1672	17	survival	survival	NN
cord-001835-0s7ok4uw	1672	18	and	and	CC
cord-001835-0s7ok4uw	1672	19	evolution	evolution	NN
cord-001835-0s7ok4uw	1672	20	for	for	IN
cord-001835-0s7ok4uw	1672	21	various	various	JJ
cord-001835-0s7ok4uw	1672	22	species	specie	NNS
cord-001835-0s7ok4uw	1672	23	.	.	.
cord-001835-0s7ok4uw	1673	1	Diversitygenerating	diversitygenerate	VBG
cord-001835-0s7ok4uw	1673	2	retroelements	retroelement	NNS
cord-001835-0s7ok4uw	1673	3	(	(	-LRB-
cord-001835-0s7ok4uw	1673	4	DGR	DGR	NNP
cord-001835-0s7ok4uw	1673	5	)	)	-RRB-
cord-001835-0s7ok4uw	1673	6	in	in	IN
cord-001835-0s7ok4uw	1673	7	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	1673	8	is	be	VBZ
cord-001835-0s7ok4uw	1673	9	known	know	VBN
cord-001835-0s7ok4uw	1673	10	to	to	TO
cord-001835-0s7ok4uw	1673	11	generate	generate	VB
cord-001835-0s7ok4uw	1673	12	massive	massive	JJ
cord-001835-0s7ok4uw	1673	13	variation	variation	NN
cord-001835-0s7ok4uw	1673	14	in	in	IN
cord-001835-0s7ok4uw	1673	15	DNA	dna	NN
cord-001835-0s7ok4uw	1673	16	through	through	IN
cord-001835-0s7ok4uw	1673	17	an	an	DT
cord-001835-0s7ok4uw	1673	18	error	error	NN
cord-001835-0s7ok4uw	1673	19	prone	prone	JJ
cord-001835-0s7ok4uw	1673	20	reverse	reverse	JJ
cord-001835-0s7ok4uw	1673	21	transcriptase	transcriptase	NN
cord-001835-0s7ok4uw	1673	22	and	and	CC
cord-001835-0s7ok4uw	1673	23	retrohoming	retrohoming	NN
cord-001835-0s7ok4uw	1673	24	,	,	,
cord-001835-0s7ok4uw	1673	25	which	which	WDT
cord-001835-0s7ok4uw	1673	26	leads	lead	VBZ
cord-001835-0s7ok4uw	1673	27	to	to	IN
cord-001835-0s7ok4uw	1673	28	variation	variation	NN
cord-001835-0s7ok4uw	1673	29	in	in	IN
cord-001835-0s7ok4uw	1673	30	protein	protein	NN
cord-001835-0s7ok4uw	1673	31	sequence	sequence	NN
cord-001835-0s7ok4uw	1673	32	.	.	.
cord-001835-0s7ok4uw	1674	1	Recent	recent	JJ
cord-001835-0s7ok4uw	1674	2	discovery	discovery	NN
cord-001835-0s7ok4uw	1674	3	of	of	IN
cord-001835-0s7ok4uw	1674	4	DGRs	dgr	NNS
cord-001835-0s7ok4uw	1674	5	in	in	IN
cord-001835-0s7ok4uw	1674	6	intraterrestrial	intraterrestrial	JJ
cord-001835-0s7ok4uw	1674	7	archaeal	archaeal	JJ
cord-001835-0s7ok4uw	1674	8	systems	system	NNS
cord-001835-0s7ok4uw	1674	9	have	have	VBP
cord-001835-0s7ok4uw	1674	10	opened	open	VBN
cord-001835-0s7ok4uw	1674	11	an	an	DT
cord-001835-0s7ok4uw	1674	12	opportunity	opportunity	NN
cord-001835-0s7ok4uw	1674	13	to	to	TO
cord-001835-0s7ok4uw	1674	14	study	study	VB
cord-001835-0s7ok4uw	1674	15	this	this	DT
cord-001835-0s7ok4uw	1674	16	massive	massive	JJ
cord-001835-0s7ok4uw	1674	17	sequence	sequence	NN
cord-001835-0s7ok4uw	1674	18	variation	variation	NN
cord-001835-0s7ok4uw	1674	19	in	in	IN
cord-001835-0s7ok4uw	1674	20	third	third	JJ
cord-001835-0s7ok4uw	1674	21	domain	domain	NN
cord-001835-0s7ok4uw	1674	22	of	of	IN
cord-001835-0s7ok4uw	1674	23	life	life	NN
cord-001835-0s7ok4uw	1674	24	(	(	-LRB-
cord-001835-0s7ok4uw	1674	25	Paul	Paul	NNP
cord-001835-0s7ok4uw	1674	26	BG	BG	NNP
cord-001835-0s7ok4uw	1674	27	,	,	,
cord-001835-0s7ok4uw	1674	28	et	et	NNP
cord-001835-0s7ok4uw	1674	29	al	al	NNP
cord-001835-0s7ok4uw	1674	30	.	.	.
cord-001835-0s7ok4uw	1675	1	Nat	Nat	NNP
cord-001835-0s7ok4uw	1675	2	.	.	.
cord-001835-0s7ok4uw	1676	1	Comm	Comm	NNP
cord-001835-0s7ok4uw	1676	2	.	.	.
cord-001835-0s7ok4uw	1676	3	)	)	-RRB-
cord-001835-0s7ok4uw	1677	1	Here	here	RB
cord-001835-0s7ok4uw	1677	2	,	,	,
cord-001835-0s7ok4uw	1677	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1677	4	present	present	VBP
cord-001835-0s7ok4uw	1677	5	the	the	DT
cord-001835-0s7ok4uw	1677	6	first	first	JJ
cord-001835-0s7ok4uw	1677	7	crystal	crystal	NN
cord-001835-0s7ok4uw	1677	8	structure	structure	NN
cord-001835-0s7ok4uw	1677	9	of	of	IN
cord-001835-0s7ok4uw	1677	10	variable	variable	JJ
cord-001835-0s7ok4uw	1677	11	protein	protein	NN
cord-001835-0s7ok4uw	1677	12	from	from	IN
cord-001835-0s7ok4uw	1677	13	archaea	archaea	NNS
cord-001835-0s7ok4uw	1677	14	with	with	IN
cord-001835-0s7ok4uw	1677	15	ligand	ligand	NN
cord-001835-0s7ok4uw	1677	16	-	-	HYPH
cord-001835-0s7ok4uw	1677	17	binding	bind	VBG
cord-001835-0s7ok4uw	1677	18	pocket	pocket	NN
cord-001835-0s7ok4uw	1677	19	is	be	VBZ
cord-001835-0s7ok4uw	1677	20	surface	surface	NN
cord-001835-0s7ok4uw	1677	21	exposed	expose	VBN
cord-001835-0s7ok4uw	1677	22	.	.	.
cord-001835-0s7ok4uw	1678	1	Also	also	RB
cord-001835-0s7ok4uw	1678	2	,	,	,
cord-001835-0s7ok4uw	1678	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	1678	4	has	have	VBZ
cord-001835-0s7ok4uw	1678	5	conserved	conserve	VBN
cord-001835-0s7ok4uw	1678	6	C	c	NN
cord-001835-0s7ok4uw	1678	7	-	-	HYPH
cord-001835-0s7ok4uw	1678	8	type	type	NN
cord-001835-0s7ok4uw	1678	9	lectin	lectin	NN
cord-001835-0s7ok4uw	1678	10	(	(	-LRB-
cord-001835-0s7ok4uw	1678	11	CLec	CLec	NNP
cord-001835-0s7ok4uw	1678	12	)	)	-RRB-
cord-001835-0s7ok4uw	1678	13	fold	fold	VBP
cord-001835-0s7ok4uw	1678	14	,	,	,
cord-001835-0s7ok4uw	1678	15	as	as	IN
cord-001835-0s7ok4uw	1678	16	shown	show	VBN
cord-001835-0s7ok4uw	1678	17	by	by	IN
cord-001835-0s7ok4uw	1678	18	previous	previous	JJ
cord-001835-0s7ok4uw	1678	19	work	work	NN
cord-001835-0s7ok4uw	1678	20	on	on	IN
cord-001835-0s7ok4uw	1678	21	variable	variable	JJ
cord-001835-0s7ok4uw	1678	22	proteins	protein	NNS
cord-001835-0s7ok4uw	1678	23	,	,	,
cord-001835-0s7ok4uw	1678	24	major	major	JJ
cord-001835-0s7ok4uw	1678	25	tropism	tropism	NN
cord-001835-0s7ok4uw	1678	26	determinant	determinant	NN
cord-001835-0s7ok4uw	1678	27	(	(	-LRB-
cord-001835-0s7ok4uw	1678	28	Mtd	Mtd	NNP
cord-001835-0s7ok4uw	1678	29	)	)	-RRB-
cord-001835-0s7ok4uw	1678	30	and	and	CC
cord-001835-0s7ok4uw	1678	31	Treponema	Treponema	NNP
cord-001835-0s7ok4uw	1678	32	variable	variable	JJ
cord-001835-0s7ok4uw	1678	33	protein	protein	NN
cord-001835-0s7ok4uw	1679	1	A	a	DT
cord-001835-0s7ok4uw	1679	2	(	(	-LRB-
cord-001835-0s7ok4uw	1679	3	TvpA	TvpA	NNP
cord-001835-0s7ok4uw	1679	4	)	)	-RRB-
cord-001835-0s7ok4uw	1679	5	which	which	WDT
cord-001835-0s7ok4uw	1679	6	bind	bind	VBP
cord-001835-0s7ok4uw	1679	7	ligands	ligand	NNS
cord-001835-0s7ok4uw	1679	8	through	through	IN
cord-001835-0s7ok4uw	1679	9	the	the	DT
cord-001835-0s7ok4uw	1679	10	CLec	CLec	NNPS
cord-001835-0s7ok4uw	1679	11	fold	fold	JJ
cord-001835-0s7ok4uw	1679	12	.	.	.
cord-001835-0s7ok4uw	1680	1	Despite	despite	IN
cord-001835-0s7ok4uw	1680	2	weak	weak	JJ
cord-001835-0s7ok4uw	1680	3	sequence	sequence	NN
cord-001835-0s7ok4uw	1680	4	identities	identity	NNS
cord-001835-0s7ok4uw	1680	5	(	(	-LRB-
cord-001835-0s7ok4uw	1680	6	10	10	CD
cord-001835-0s7ok4uw	1680	7	-	-	SYM
cord-001835-0s7ok4uw	1680	8	15	15	CD
cord-001835-0s7ok4uw	1680	9	%	%	NN
cord-001835-0s7ok4uw	1680	10	)	)	-RRB-
cord-001835-0s7ok4uw	1680	11	among	among	IN
cord-001835-0s7ok4uw	1680	12	these	these	DT
cord-001835-0s7ok4uw	1680	13	variable	variable	JJ
cord-001835-0s7ok4uw	1680	14	proteins	protein	NNS
cord-001835-0s7ok4uw	1680	15	,	,	,
cord-001835-0s7ok4uw	1680	16	CLec	CLec	NNPS
cord-001835-0s7ok4uw	1680	17	fold	fold	NN
cord-001835-0s7ok4uw	1680	18	was	be	VBD
cord-001835-0s7ok4uw	1680	19	found	find	VBN
cord-001835-0s7ok4uw	1680	20	to	to	TO
cord-001835-0s7ok4uw	1680	21	be	be	VB
cord-001835-0s7ok4uw	1680	22	conserved	conserve	VBN
cord-001835-0s7ok4uw	1680	23	.	.	.
cord-001835-0s7ok4uw	1681	1	This	this	DT
cord-001835-0s7ok4uw	1681	2	variable	variable	JJ
cord-001835-0s7ok4uw	1681	3	ligand	ligand	NN
cord-001835-0s7ok4uw	1681	4	-	-	HYPH
cord-001835-0s7ok4uw	1681	5	binding	bind	VBG
cord-001835-0s7ok4uw	1681	6	site	site	NN
cord-001835-0s7ok4uw	1681	7	for	for	IN
cord-001835-0s7ok4uw	1681	8	archaea	archaea	NNP
cord-001835-0s7ok4uw	1681	9	variable	variable	JJ
cord-001835-0s7ok4uw	1681	10	proteins	protein	NNS
cord-001835-0s7ok4uw	1681	11	can	can	MD
cord-001835-0s7ok4uw	1681	12	potentially	potentially	RB
cord-001835-0s7ok4uw	1681	13	generate	generate	VB
cord-001835-0s7ok4uw	1681	14	1013	1013	CD
cord-001835-0s7ok4uw	1681	15	variants	variant	NNS
cord-001835-0s7ok4uw	1681	16	.	.	.
cord-001835-0s7ok4uw	1682	1	Protein	protein	NN
cord-001835-0s7ok4uw	1682	2	synthesis	synthesis	NN
cord-001835-0s7ok4uw	1682	3	is	be	VBZ
cord-001835-0s7ok4uw	1682	4	a	a	DT
cord-001835-0s7ok4uw	1682	5	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	1682	6	process	process	NN
cord-001835-0s7ok4uw	1682	7	mediated	mediate	VBN
cord-001835-0s7ok4uw	1682	8	by	by	IN
cord-001835-0s7ok4uw	1682	9	a	a	DT
cord-001835-0s7ok4uw	1682	10	variety	variety	NN
cord-001835-0s7ok4uw	1682	11	of	of	IN
cord-001835-0s7ok4uw	1682	12	proteins	protein	NNS
cord-001835-0s7ok4uw	1682	13	and	and	CC
cord-001835-0s7ok4uw	1682	14	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	1682	15	.	.	.
cord-001835-0s7ok4uw	1683	1	Recent	recent	JJ
cord-001835-0s7ok4uw	1683	2	studies	study	NNS
cord-001835-0s7ok4uw	1683	3	have	have	VBP
cord-001835-0s7ok4uw	1683	4	shown	show	VBN
cord-001835-0s7ok4uw	1683	5	that	that	IN
cord-001835-0s7ok4uw	1683	6	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	1683	7	is	be	VBZ
cord-001835-0s7ok4uw	1683	8	a	a	DT
cord-001835-0s7ok4uw	1683	9	key	key	JJ
cord-001835-0s7ok4uw	1683	10	post	post	JJ
cord-001835-0s7ok4uw	1683	11	-	-	JJ
cord-001835-0s7ok4uw	1683	12	translational	translational	JJ
cord-001835-0s7ok4uw	1683	13	modification	modification	NN
cord-001835-0s7ok4uw	1683	14	involved	involve	VBN
cord-001835-0s7ok4uw	1683	15	in	in	IN
cord-001835-0s7ok4uw	1683	16	translation	translation	NN
cord-001835-0s7ok4uw	1683	17	termination	termination	NN
cord-001835-0s7ok4uw	1683	18	.	.	.
cord-001835-0s7ok4uw	1684	1	In	in	IN
cord-001835-0s7ok4uw	1684	2	particular	particular	JJ
cord-001835-0s7ok4uw	1684	3	,	,	,
cord-001835-0s7ok4uw	1684	4	the	the	DT
cord-001835-0s7ok4uw	1684	5	Fe(II)-and	fe(ii)-and	NN
cord-001835-0s7ok4uw	1684	6	2-oxoglutarate	2-oxoglutarate	CD
cord-001835-0s7ok4uw	1684	7	-	-	HYPH
cord-001835-0s7ok4uw	1684	8	dependent	dependent	JJ
cord-001835-0s7ok4uw	1684	9	oxygenase	oxygenase	NN
cord-001835-0s7ok4uw	1684	10	,	,	,
cord-001835-0s7ok4uw	1684	11	Jumonji	Jumonji	NNP
cord-001835-0s7ok4uw	1684	12	domaincontaining	domaincontaine	VBG
cord-001835-0s7ok4uw	1684	13	4	4	CD
cord-001835-0s7ok4uw	1684	14	(	(	-LRB-
cord-001835-0s7ok4uw	1684	15	JMJD4	JMJD4	NNP
cord-001835-0s7ok4uw	1684	16	)	)	-RRB-
cord-001835-0s7ok4uw	1684	17	,	,	,
cord-001835-0s7ok4uw	1684	18	regulates	regulate	VBZ
cord-001835-0s7ok4uw	1684	19	translation	translation	NN
cord-001835-0s7ok4uw	1684	20	termination	termination	NN
cord-001835-0s7ok4uw	1684	21	via	via	IN
cord-001835-0s7ok4uw	1684	22	the	the	DT
cord-001835-0s7ok4uw	1684	23	carbon	carbon	NN
cord-001835-0s7ok4uw	1684	24	4	4	CD
cord-001835-0s7ok4uw	1684	25	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	1684	26	of	of	IN
cord-001835-0s7ok4uw	1684	27	an	an	DT
cord-001835-0s7ok4uw	1684	28	invariant	invariant	JJ
cord-001835-0s7ok4uw	1684	29	lysine	lysine	NN
cord-001835-0s7ok4uw	1684	30	residue	residue	NN
cord-001835-0s7ok4uw	1684	31	,	,	,
cord-001835-0s7ok4uw	1684	32	K63	K63	NNP
cord-001835-0s7ok4uw	1684	33	,	,	,
cord-001835-0s7ok4uw	1684	34	of	of	IN
cord-001835-0s7ok4uw	1684	35	the	the	DT
cord-001835-0s7ok4uw	1684	36	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	1684	37	release	release	NN
cord-001835-0s7ok4uw	1684	38	factor	factor	NN
cord-001835-0s7ok4uw	1684	39	,	,	,
cord-001835-0s7ok4uw	1685	1	eRF1	erf1	RB
cord-001835-0s7ok4uw	1685	2	.	.	.
cord-001835-0s7ok4uw	1686	1	In	in	IN
cord-001835-0s7ok4uw	1686	2	eukaryotes	eukaryote	NNS
cord-001835-0s7ok4uw	1686	3	,	,	,
cord-001835-0s7ok4uw	1686	4	translation	translation	NN
cord-001835-0s7ok4uw	1686	5	termination	termination	NN
cord-001835-0s7ok4uw	1686	6	is	be	VBZ
cord-001835-0s7ok4uw	1686	7	mediated	mediate	VBN
cord-001835-0s7ok4uw	1686	8	by	by	IN
cord-001835-0s7ok4uw	1686	9	a	a	DT
cord-001835-0s7ok4uw	1686	10	release	release	NN
cord-001835-0s7ok4uw	1686	11	factor	factor	NN
cord-001835-0s7ok4uw	1686	12	complex	complex	NN
cord-001835-0s7ok4uw	1686	13	that	that	WDT
cord-001835-0s7ok4uw	1686	14	includes	include	VBZ
cord-001835-0s7ok4uw	1686	15	eRF1	erf1	RB
cord-001835-0s7ok4uw	1686	16	.	.	.
cord-001835-0s7ok4uw	1687	1	eRF1	eRF1	NNP
cord-001835-0s7ok4uw	1687	2	is	be	VBZ
cord-001835-0s7ok4uw	1687	3	comprised	comprise	VBN
cord-001835-0s7ok4uw	1687	4	of	of	IN
cord-001835-0s7ok4uw	1687	5	three	three	CD
cord-001835-0s7ok4uw	1687	6	domains	domain	NNS
cord-001835-0s7ok4uw	1687	7	,	,	,
cord-001835-0s7ok4uw	1687	8	and	and	CC
cord-001835-0s7ok4uw	1687	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	1687	10	is	be	VBZ
cord-001835-0s7ok4uw	1687	11	responsible	responsible	JJ
cord-001835-0s7ok4uw	1687	12	for	for	IN
cord-001835-0s7ok4uw	1687	13	recognizing	recognize	VBG
cord-001835-0s7ok4uw	1687	14	stop	stop	VB
cord-001835-0s7ok4uw	1687	15	codons	codon	NNS
cord-001835-0s7ok4uw	1687	16	in	in	IN
cord-001835-0s7ok4uw	1687	17	mRNA	mRNA	NNP
cord-001835-0s7ok4uw	1687	18	transcripts	transcript	NNS
cord-001835-0s7ok4uw	1687	19	before	before	IN
cord-001835-0s7ok4uw	1687	20	triggering	trigger	VBG
cord-001835-0s7ok4uw	1687	21	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	1687	22	release	release	NN
cord-001835-0s7ok4uw	1687	23	from	from	IN
cord-001835-0s7ok4uw	1687	24	the	the	DT
cord-001835-0s7ok4uw	1687	25	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1687	26	.	.	.
cord-001835-0s7ok4uw	1688	1	The	the	DT
cord-001835-0s7ok4uw	1688	2	lysine	lysine	NN
cord-001835-0s7ok4uw	1688	3	residue	residue	NN
cord-001835-0s7ok4uw	1688	4	hydroxylated	hydroxylate	VBN
cord-001835-0s7ok4uw	1688	5	by	by	IN
cord-001835-0s7ok4uw	1688	6	JMJD4	JMJD4	NNP
cord-001835-0s7ok4uw	1688	7	falls	fall	VBZ
cord-001835-0s7ok4uw	1688	8	within	within	IN
cord-001835-0s7ok4uw	1688	9	the	the	DT
cord-001835-0s7ok4uw	1688	10	N	n	CD
cord-001835-0s7ok4uw	1688	11	-	-	HYPH
cord-001835-0s7ok4uw	1688	12	terminal	terminal	NN
cord-001835-0s7ok4uw	1688	13	domain	domain	NN
cord-001835-0s7ok4uw	1688	14	and	and	CC
cord-001835-0s7ok4uw	1688	15	more	more	JJR
cord-001835-0s7ok4uw	1688	16	specifically	specifically	RB
cord-001835-0s7ok4uw	1688	17	within	within	IN
cord-001835-0s7ok4uw	1688	18	the	the	DT
cord-001835-0s7ok4uw	1688	19	highly	highly	RB
cord-001835-0s7ok4uw	1688	20	conserved	conserved	JJ
cord-001835-0s7ok4uw	1688	21	NIKS	niks	NN
cord-001835-0s7ok4uw	1688	22	motif	motif	NN
cord-001835-0s7ok4uw	1688	23	.	.	.
cord-001835-0s7ok4uw	1689	1	This	this	DT
cord-001835-0s7ok4uw	1689	2	motif	motif	NN
cord-001835-0s7ok4uw	1689	3	has	have	VBZ
cord-001835-0s7ok4uw	1689	4	been	be	VBN
cord-001835-0s7ok4uw	1689	5	identified	identify	VBN
cord-001835-0s7ok4uw	1689	6	by	by	IN
cord-001835-0s7ok4uw	1689	7	cross	cross	NN
cord-001835-0s7ok4uw	1689	8	-	-	JJ
cord-001835-0s7ok4uw	1689	9	linking	linking	JJ
cord-001835-0s7ok4uw	1689	10	and	and	CC
cord-001835-0s7ok4uw	1689	11	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	1689	12	studies	study	NNS
cord-001835-0s7ok4uw	1689	13	to	to	TO
cord-001835-0s7ok4uw	1689	14	play	play	VB
cord-001835-0s7ok4uw	1689	15	an	an	DT
cord-001835-0s7ok4uw	1689	16	essential	essential	JJ
cord-001835-0s7ok4uw	1689	17	role	role	NN
cord-001835-0s7ok4uw	1689	18	in	in	IN
cord-001835-0s7ok4uw	1689	19	stop	stop	NN
cord-001835-0s7ok4uw	1689	20	codon	codon	NN
cord-001835-0s7ok4uw	1689	21	recognition	recognition	NN
cord-001835-0s7ok4uw	1689	22	.	.	.
cord-001835-0s7ok4uw	1690	1	While	while	IN
cord-001835-0s7ok4uw	1690	2	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	1690	3	of	of	IN
cord-001835-0s7ok4uw	1690	4	K63	K63	NNP
cord-001835-0s7ok4uw	1690	5	by	by	IN
cord-001835-0s7ok4uw	1690	6	JMJD4	JMJD4	NNP
cord-001835-0s7ok4uw	1690	7	has	have	VBZ
cord-001835-0s7ok4uw	1690	8	been	be	VBN
cord-001835-0s7ok4uw	1690	9	found	find	VBN
cord-001835-0s7ok4uw	1690	10	to	to	TO
cord-001835-0s7ok4uw	1690	11	increase	increase	VB
cord-001835-0s7ok4uw	1690	12	translational	translational	JJ
cord-001835-0s7ok4uw	1690	13	termination	termination	NN
cord-001835-0s7ok4uw	1690	14	efficiency	efficiency	NN
cord-001835-0s7ok4uw	1690	15	,	,	,
cord-001835-0s7ok4uw	1690	16	the	the	DT
cord-001835-0s7ok4uw	1690	17	exact	exact	JJ
cord-001835-0s7ok4uw	1690	18	molecular	molecular	JJ
cord-001835-0s7ok4uw	1690	19	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1690	20	by	by	IN
cord-001835-0s7ok4uw	1690	21	which	which	WDT
cord-001835-0s7ok4uw	1690	22	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	1690	23	influences	influence	NNS
cord-001835-0s7ok4uw	1690	24	termination	termination	NN
cord-001835-0s7ok4uw	1690	25	remains	remain	VBZ
cord-001835-0s7ok4uw	1690	26	unclear	unclear	JJ
cord-001835-0s7ok4uw	1690	27	.	.	.
cord-001835-0s7ok4uw	1691	1	This	this	DT
cord-001835-0s7ok4uw	1691	2	work	work	NN
cord-001835-0s7ok4uw	1691	3	aims	aim	VBZ
cord-001835-0s7ok4uw	1691	4	to	to	TO
cord-001835-0s7ok4uw	1691	5	understand	understand	VB
cord-001835-0s7ok4uw	1691	6	how	how	WRB
cord-001835-0s7ok4uw	1691	7	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	1691	8	of	of	IN
cord-001835-0s7ok4uw	1691	9	eRF1	eRF1	NNP
cord-001835-0s7ok4uw	1691	10	affects	affect	VBZ
cord-001835-0s7ok4uw	1691	11	translation	translation	NN
cord-001835-0s7ok4uw	1691	12	termination	termination	NN
cord-001835-0s7ok4uw	1691	13	by	by	IN
cord-001835-0s7ok4uw	1691	14	exploring	explore	VBG
cord-001835-0s7ok4uw	1691	15	the	the	DT
cord-001835-0s7ok4uw	1691	16	effect	effect	NN
cord-001835-0s7ok4uw	1691	17	of	of	IN
cord-001835-0s7ok4uw	1691	18	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	1691	19	on	on	IN
cord-001835-0s7ok4uw	1691	20	the	the	DT
cord-001835-0s7ok4uw	1691	21	structure	structure	NN
cord-001835-0s7ok4uw	1691	22	,	,	,
cord-001835-0s7ok4uw	1691	23	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1691	24	,	,	,
cord-001835-0s7ok4uw	1691	25	stability	stability	NN
cord-001835-0s7ok4uw	1691	26	,	,	,
cord-001835-0s7ok4uw	1691	27	and	and	CC
cord-001835-0s7ok4uw	1691	28	binding	binding	NN
cord-001835-0s7ok4uw	1691	29	of	of	IN
cord-001835-0s7ok4uw	1691	30	the	the	DT
cord-001835-0s7ok4uw	1691	31	N	n	CD
cord-001835-0s7ok4uw	1691	32	-	-	HYPH
cord-001835-0s7ok4uw	1691	33	terminal	terminal	NN
cord-001835-0s7ok4uw	1691	34	domain	domain	NN
cord-001835-0s7ok4uw	1691	35	of	of	IN
cord-001835-0s7ok4uw	1691	36	eRF1	eRF1	NNP
cord-001835-0s7ok4uw	1691	37	(	(	-LRB-
cord-001835-0s7ok4uw	1691	38	eRF1-N	eRF1-N	NNP
cord-001835-0s7ok4uw	1691	39	)	)	-RRB-
cord-001835-0s7ok4uw	1691	40	using	use	VBG
cord-001835-0s7ok4uw	1691	41	mass	mass	NN
cord-001835-0s7ok4uw	1691	42	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	1691	43	,	,	,
cord-001835-0s7ok4uw	1691	44	protein	protein	NN
cord-001835-0s7ok4uw	1691	45	NMR	NMR	NNP
cord-001835-0s7ok4uw	1691	46	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1691	47	,	,	,
cord-001835-0s7ok4uw	1691	48	circular	circular	JJ
cord-001835-0s7ok4uw	1691	49	dichroism	dichroism	NN
cord-001835-0s7ok4uw	1691	50	and	and	CC
cord-001835-0s7ok4uw	1691	51	differential	differential	JJ
cord-001835-0s7ok4uw	1691	52	scanning	scanning	NN
cord-001835-0s7ok4uw	1691	53	fluorimetry	fluorimetry	NN
cord-001835-0s7ok4uw	1691	54	.	.	.
cord-001835-0s7ok4uw	1692	1	In	in	IN
cord-001835-0s7ok4uw	1692	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1692	3	efforts	effort	NNS
cord-001835-0s7ok4uw	1692	4	to	to	TO
cord-001835-0s7ok4uw	1692	5	understand	understand	VB
cord-001835-0s7ok4uw	1692	6	the	the	DT
cord-001835-0s7ok4uw	1692	7	effect	effect	NN
cord-001835-0s7ok4uw	1692	8	of	of	IN
cord-001835-0s7ok4uw	1692	9	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	1692	10	,	,	,
cord-001835-0s7ok4uw	1692	11	an	an	DT
cord-001835-0s7ok4uw	1692	12	additional	additional	JJ
cord-001835-0s7ok4uw	1692	13	JMJD4-catalyzed	JMJD4-catalyzed	NNP
cord-001835-0s7ok4uw	1692	14	modification	modification	NN
cord-001835-0s7ok4uw	1692	15	,	,	,
cord-001835-0s7ok4uw	1692	16	characterized	characterize	VBN
cord-001835-0s7ok4uw	1692	17	by	by	IN
cord-001835-0s7ok4uw	1692	18	a	a	DT
cord-001835-0s7ok4uw	1692	19	130	130	CD
cord-001835-0s7ok4uw	1692	20	Da	Da	NNP
cord-001835-0s7ok4uw	1692	21	mass	mass	JJ
cord-001835-0s7ok4uw	1692	22	shift	shift	NN
cord-001835-0s7ok4uw	1692	23	on	on	IN
cord-001835-0s7ok4uw	1692	24	K63	K63	NNP
cord-001835-0s7ok4uw	1692	25	,	,	,
cord-001835-0s7ok4uw	1692	26	was	be	VBD
cord-001835-0s7ok4uw	1692	27	identified	identify	VBN
cord-001835-0s7ok4uw	1692	28	in	in	IN
cord-001835-0s7ok4uw	1692	29	vitro	vitro	FW
cord-001835-0s7ok4uw	1692	30	.	.	.
cord-001835-0s7ok4uw	1693	1	The	the	DT
cord-001835-0s7ok4uw	1693	2	effect	effect	NN
cord-001835-0s7ok4uw	1693	3	of	of	IN
cord-001835-0s7ok4uw	1693	4	this	this	DT
cord-001835-0s7ok4uw	1693	5	modification	modification	NN
cord-001835-0s7ok4uw	1693	6	on	on	IN
cord-001835-0s7ok4uw	1693	7	eRF1	eRF1	NNP
cord-001835-0s7ok4uw	1693	8	was	be	VBD
cord-001835-0s7ok4uw	1693	9	similarly	similarly	RB
cord-001835-0s7ok4uw	1693	10	explored	explore	VBN
cord-001835-0s7ok4uw	1693	11	.	.	.
cord-001835-0s7ok4uw	1694	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1694	2	findings	finding	NNS
cord-001835-0s7ok4uw	1694	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	1694	4	that	that	IN
cord-001835-0s7ok4uw	1694	5	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	1694	6	has	have	VBZ
cord-001835-0s7ok4uw	1694	7	no	no	DT
cord-001835-0s7ok4uw	1694	8	effect	effect	NN
cord-001835-0s7ok4uw	1694	9	on	on	IN
cord-001835-0s7ok4uw	1694	10	the	the	DT
cord-001835-0s7ok4uw	1694	11	in	in	IN
cord-001835-0s7ok4uw	1694	12	-	-	HYPH
cord-001835-0s7ok4uw	1694	13	solution	solution	NN
cord-001835-0s7ok4uw	1694	14	NMR	NMR	NNP
cord-001835-0s7ok4uw	1694	15	structure	structure	NN
cord-001835-0s7ok4uw	1694	16	of	of	IN
cord-001835-0s7ok4uw	1694	17	eRF1-N	eRF1-N	NNP
cord-001835-0s7ok4uw	1694	18	,	,	,
cord-001835-0s7ok4uw	1694	19	which	which	WDT
cord-001835-0s7ok4uw	1694	20	experiences	experience	VBZ
cord-001835-0s7ok4uw	1694	21	chemical	chemical	NN
cord-001835-0s7ok4uw	1694	22	shift	shift	NN
cord-001835-0s7ok4uw	1694	23	changes	change	NNS
cord-001835-0s7ok4uw	1694	24	localized	localize	VBN
cord-001835-0s7ok4uw	1694	25	to	to	IN
cord-001835-0s7ok4uw	1694	26	the	the	DT
cord-001835-0s7ok4uw	1694	27	target	target	NN
cord-001835-0s7ok4uw	1694	28	lysine	lysine	NN
cord-001835-0s7ok4uw	1694	29	residue	residue	NN
cord-001835-0s7ok4uw	1694	30	.	.	.
cord-001835-0s7ok4uw	1695	1	Correspondingly	correspondingly	RB
cord-001835-0s7ok4uw	1695	2	,	,	,
cord-001835-0s7ok4uw	1695	3	there	there	EX
cord-001835-0s7ok4uw	1695	4	are	be	VBP
cord-001835-0s7ok4uw	1695	5	no	no	DT
cord-001835-0s7ok4uw	1695	6	significant	significant	JJ
cord-001835-0s7ok4uw	1695	7	differences	difference	NNS
cord-001835-0s7ok4uw	1695	8	in	in	IN
cord-001835-0s7ok4uw	1695	9	secondary	secondary	JJ
cord-001835-0s7ok4uw	1695	10	structure	structure	NN
cord-001835-0s7ok4uw	1695	11	content	content	NN
cord-001835-0s7ok4uw	1695	12	between	between	IN
cord-001835-0s7ok4uw	1695	13	wild	wild	JJ
cord-001835-0s7ok4uw	1695	14	type	type	NN
cord-001835-0s7ok4uw	1695	15	and	and	CC
cord-001835-0s7ok4uw	1695	16	hydroxylated	hydroxylated	NNP
cord-001835-0s7ok4uw	1695	17	eRF1-N.	erf1-n.	XX
cord-001835-0s7ok4uw	1696	1	Hydroxylation	Hydroxylation	NNP
cord-001835-0s7ok4uw	1696	2	was	be	VBD
cord-001835-0s7ok4uw	1696	3	also	also	RB
cord-001835-0s7ok4uw	1696	4	found	find	VBN
cord-001835-0s7ok4uw	1696	5	to	to	TO
cord-001835-0s7ok4uw	1696	6	have	have	VB
cord-001835-0s7ok4uw	1696	7	no	no	DT
cord-001835-0s7ok4uw	1696	8	effect	effect	NN
cord-001835-0s7ok4uw	1696	9	on	on	IN
cord-001835-0s7ok4uw	1696	10	protein	protein	NN
cord-001835-0s7ok4uw	1696	11	stability	stability	NN
cord-001835-0s7ok4uw	1696	12	or	or	CC
cord-001835-0s7ok4uw	1696	13	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1696	14	.	.	.
cord-001835-0s7ok4uw	1697	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	1697	2	however	however	RB
cord-001835-0s7ok4uw	1697	3	,	,	,
cord-001835-0s7ok4uw	1697	4	the	the	DT
cord-001835-0s7ok4uw	1697	5	130	130	CD
cord-001835-0s7ok4uw	1697	6	Da	Da	NNP
cord-001835-0s7ok4uw	1697	7	modification	modification	NN
cord-001835-0s7ok4uw	1697	8	appears	appear	VBZ
cord-001835-0s7ok4uw	1697	9	to	to	TO
cord-001835-0s7ok4uw	1697	10	cause	cause	VB
cord-001835-0s7ok4uw	1697	11	more	more	RBR
cord-001835-0s7ok4uw	1697	12	significant	significant	JJ
cord-001835-0s7ok4uw	1697	13	chemical	chemical	NN
cord-001835-0s7ok4uw	1697	14	shift	shift	NN
cord-001835-0s7ok4uw	1697	15	changes	change	NNS
cord-001835-0s7ok4uw	1697	16	dispersed	disperse	VBD
cord-001835-0s7ok4uw	1697	17	beyond	beyond	IN
cord-001835-0s7ok4uw	1697	18	the	the	DT
cord-001835-0s7ok4uw	1697	19	NIKS	NIKS	NNP
cord-001835-0s7ok4uw	1697	20	motif	motif	NN
cord-001835-0s7ok4uw	1697	21	.	.	.
cord-001835-0s7ok4uw	1698	1	This	this	DT
cord-001835-0s7ok4uw	1698	2	suggests	suggest	VBZ
cord-001835-0s7ok4uw	1698	3	a	a	DT
cord-001835-0s7ok4uw	1698	4	more	more	RBR
cord-001835-0s7ok4uw	1698	5	global	global	JJ
cord-001835-0s7ok4uw	1698	6	effect	effect	NN
cord-001835-0s7ok4uw	1698	7	on	on	IN
cord-001835-0s7ok4uw	1698	8	the	the	DT
cord-001835-0s7ok4uw	1698	9	in	in	IN
cord-001835-0s7ok4uw	1698	10	-	-	HYPH
cord-001835-0s7ok4uw	1698	11	solution	solution	NN
cord-001835-0s7ok4uw	1698	12	NMR	NMR	NNP
cord-001835-0s7ok4uw	1698	13	structure	structure	NN
cord-001835-0s7ok4uw	1698	14	despite	despite	IN
cord-001835-0s7ok4uw	1698	15	the	the	DT
cord-001835-0s7ok4uw	1698	16	little	little	JJ
cord-001835-0s7ok4uw	1698	17	differences	difference	NNS
cord-001835-0s7ok4uw	1698	18	observed	observe	VBN
cord-001835-0s7ok4uw	1698	19	in	in	IN
cord-001835-0s7ok4uw	1698	20	protein	protein	NN
cord-001835-0s7ok4uw	1698	21	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1698	22	and	and	CC
cord-001835-0s7ok4uw	1698	23	secondary	secondary	JJ
cord-001835-0s7ok4uw	1698	24	structure	structure	NN
cord-001835-0s7ok4uw	1698	25	content	content	NN
cord-001835-0s7ok4uw	1698	26	.	.	.
cord-001835-0s7ok4uw	1699	1	The	the	DT
cord-001835-0s7ok4uw	1699	2	130	130	CD
cord-001835-0s7ok4uw	1699	3	Da	Da	NNP
cord-001835-0s7ok4uw	1699	4	modification	modification	NN
cord-001835-0s7ok4uw	1699	5	was	be	VBD
cord-001835-0s7ok4uw	1699	6	also	also	RB
cord-001835-0s7ok4uw	1699	7	found	find	VBN
cord-001835-0s7ok4uw	1699	8	to	to	TO
cord-001835-0s7ok4uw	1699	9	have	have	VB
cord-001835-0s7ok4uw	1699	10	a	a	DT
cord-001835-0s7ok4uw	1699	11	destabilizing	destabilizing	JJ
cord-001835-0s7ok4uw	1699	12	effect	effect	NN
cord-001835-0s7ok4uw	1699	13	on	on	IN
cord-001835-0s7ok4uw	1699	14	eRF1-N.	eRF1-N.	NNP
cord-001835-0s7ok4uw	1700	1	Neither	neither	CC
cord-001835-0s7ok4uw	1700	2	hydroxylated	hydroxylated	JJ
cord-001835-0s7ok4uw	1700	3	nor	nor	CC
cord-001835-0s7ok4uw	1700	4	130	130	CD
cord-001835-0s7ok4uw	1700	5	Da	Da	NNP
cord-001835-0s7ok4uw	1700	6	modified	modify	VBN
cord-001835-0s7ok4uw	1700	7	eRF1-N	erf1-n	CD
cord-001835-0s7ok4uw	1700	8	exhibited	exhibit	VBN
cord-001835-0s7ok4uw	1700	9	differences	difference	NNS
cord-001835-0s7ok4uw	1700	10	in	in	IN
cord-001835-0s7ok4uw	1700	11	rRNA	rrna	NN
cord-001835-0s7ok4uw	1700	12	binding	binding	NN
cord-001835-0s7ok4uw	1700	13	.	.	.
cord-001835-0s7ok4uw	1701	1	While	while	IN
cord-001835-0s7ok4uw	1701	2	hydroxylation	hydroxylation	NN
cord-001835-0s7ok4uw	1701	3	of	of	IN
cord-001835-0s7ok4uw	1701	4	eRF1	eRF1	NNP
cord-001835-0s7ok4uw	1701	5	was	be	VBD
cord-001835-0s7ok4uw	1701	6	found	find	VBN
cord-001835-0s7ok4uw	1701	7	to	to	TO
cord-001835-0s7ok4uw	1701	8	have	have	VB
cord-001835-0s7ok4uw	1701	9	little	little	JJ
cord-001835-0s7ok4uw	1701	10	effect	effect	NN
cord-001835-0s7ok4uw	1701	11	on	on	IN
cord-001835-0s7ok4uw	1701	12	protein	protein	NN
cord-001835-0s7ok4uw	1701	13	structure	structure	NN
cord-001835-0s7ok4uw	1701	14	,	,	,
cord-001835-0s7ok4uw	1701	15	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1701	16	,	,	,
cord-001835-0s7ok4uw	1701	17	stability	stability	NN
cord-001835-0s7ok4uw	1701	18	,	,	,
cord-001835-0s7ok4uw	1701	19	or	or	CC
cord-001835-0s7ok4uw	1701	20	binding	binding	NN
cord-001835-0s7ok4uw	1701	21	,	,	,
cord-001835-0s7ok4uw	1701	22	the	the	DT
cord-001835-0s7ok4uw	1701	23	130	130	CD
cord-001835-0s7ok4uw	1701	24	Da	Da	NNP
cord-001835-0s7ok4uw	1701	25	modification	modification	NN
cord-001835-0s7ok4uw	1701	26	has	have	VBZ
cord-001835-0s7ok4uw	1701	27	marked	mark	VBN
cord-001835-0s7ok4uw	1701	28	effects	effect	NNS
cord-001835-0s7ok4uw	1701	29	on	on	IN
cord-001835-0s7ok4uw	1701	30	protein	protein	NN
cord-001835-0s7ok4uw	1701	31	structure	structure	NN
cord-001835-0s7ok4uw	1701	32	and	and	CC
cord-001835-0s7ok4uw	1701	33	stability	stability	NN
cord-001835-0s7ok4uw	1701	34	.	.	.
cord-001835-0s7ok4uw	1702	1	Such	such	JJ
cord-001835-0s7ok4uw	1702	2	differences	difference	NNS
cord-001835-0s7ok4uw	1702	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	1702	4	that	that	IN
cord-001835-0s7ok4uw	1702	5	this	this	DT
cord-001835-0s7ok4uw	1702	6	modification	modification	NN
cord-001835-0s7ok4uw	1702	7	has	have	VBZ
cord-001835-0s7ok4uw	1702	8	the	the	DT
cord-001835-0s7ok4uw	1702	9	potential	potential	NN
cord-001835-0s7ok4uw	1702	10	to	to	TO
cord-001835-0s7ok4uw	1702	11	play	play	VB
cord-001835-0s7ok4uw	1702	12	an	an	DT
cord-001835-0s7ok4uw	1702	13	important	important	JJ
cord-001835-0s7ok4uw	1702	14	role	role	NN
cord-001835-0s7ok4uw	1702	15	in	in	IN
cord-001835-0s7ok4uw	1702	16	translation	translation	NN
cord-001835-0s7ok4uw	1702	17	.	.	.
cord-001835-0s7ok4uw	1703	1	Functional	functional	JJ
cord-001835-0s7ok4uw	1703	2	and	and	CC
cord-001835-0s7ok4uw	1703	3	structural	structural	JJ
cord-001835-0s7ok4uw	1703	4	analysis	analysis	NN
cord-001835-0s7ok4uw	1703	5	of	of	IN
cord-001835-0s7ok4uw	1703	6	a	a	DT
cord-001835-0s7ok4uw	1703	7	GH20	GH20	NNP
cord-001835-0s7ok4uw	1703	8	ß	ß	NN
cord-001835-0s7ok4uw	1703	9	-	-	HYPH
cord-001835-0s7ok4uw	1703	10	N	n	NN
cord-001835-0s7ok4uw	1703	11	-	-	HYPH
cord-001835-0s7ok4uw	1703	12	acetylglucosaminidase	acetylglucosaminidase	NN
cord-001835-0s7ok4uw	1703	13	from	from	IN
cord-001835-0s7ok4uw	1703	14	the	the	DT
cord-001835-0s7ok4uw	1703	15	marine	marine	JJ
cord-001835-0s7ok4uw	1703	16	bacterium	bacterium	NN
cord-001835-0s7ok4uw	1703	17	Vibrio	Vibrio	NNP
cord-001835-0s7ok4uw	1703	18	harveyi	harveyi	NN
cord-001835-0s7ok4uw	1704	1	Piyanat	Piyanat	NNP
cord-001835-0s7ok4uw	1704	2	Meekrathok	Meekrathok	NNP
cord-001835-0s7ok4uw	1704	3	1	1	CD
cord-001835-0s7ok4uw	1704	4	,	,	,
cord-001835-0s7ok4uw	1704	5	Arthur	Arthur	NNP
cord-001835-0s7ok4uw	1704	6	T.	T.	NNP
cord-001835-0s7ok4uw	1704	7	Porfetye	Porfetye	NNP
cord-001835-0s7ok4uw	1704	8	2	2	CD
cord-001835-0s7ok4uw	1704	9	,	,	,
cord-001835-0s7ok4uw	1704	10	Marco	Marco	NNP
cord-001835-0s7ok4uw	1704	11	B€	B€	NNP
cord-001835-0s7ok4uw	1704	12	urger	urger	NNP
cord-001835-0s7ok4uw	1704	13	2	2	CD
cord-001835-0s7ok4uw	1704	14	,	,	,
cord-001835-0s7ok4uw	1704	15	Ingrid	Ingrid	NNP
cord-001835-0s7ok4uw	1704	16	R.	R.	NNP
cord-001835-0s7ok4uw	1704	17	Vetter	Vetter	NNP
cord-001835-0s7ok4uw	1704	18	2	2	CD
cord-001835-0s7ok4uw	1705	1	,	,	,
cord-001835-0s7ok4uw	1705	2	Wipa	Wipa	NNP
cord-001835-0s7ok4uw	1705	3	Suginta	Suginta	NNP
cord-001835-0s7ok4uw	1705	4	1	1	CD
cord-001835-0s7ok4uw	1705	5	1	1	CD
cord-001835-0s7ok4uw	1705	6	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	1705	7	-	-	HYPH
cord-001835-0s7ok4uw	1705	8	Electrochemistry	Electrochemistry	NNP
cord-001835-0s7ok4uw	1705	9	Research	Research	NNP
cord-001835-0s7ok4uw	1705	10	Unit	Unit	NNP
cord-001835-0s7ok4uw	1705	11	,	,	,
cord-001835-0s7ok4uw	1705	12	Suranaree	Suranaree	NNP
cord-001835-0s7ok4uw	1705	13	University	University	NNP
cord-001835-0s7ok4uw	1705	14	of	of	IN
cord-001835-0s7ok4uw	1705	15	Technology	Technology	NNP
cord-001835-0s7ok4uw	1705	16	,	,	,
cord-001835-0s7ok4uw	1705	17	2	2	CD
cord-001835-0s7ok4uw	1705	18	Max	Max	NNP
cord-001835-0s7ok4uw	1705	19	Planck	Planck	NNP
cord-001835-0s7ok4uw	1705	20	Institute	Institute	NNP
cord-001835-0s7ok4uw	1705	21	of	of	IN
cord-001835-0s7ok4uw	1705	22	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	1705	23	Physiology	Physiology	NNP
cord-001835-0s7ok4uw	1705	24	Vibrio	Vibrio	NNP
cord-001835-0s7ok4uw	1705	25	harveyi	harveyi	NN
cord-001835-0s7ok4uw	1705	26	b	b	NNP
cord-001835-0s7ok4uw	1705	27	-	-	:
cord-001835-0s7ok4uw	1705	28	N	N	NNP
cord-001835-0s7ok4uw	1705	29	-	-	HYPH
cord-001835-0s7ok4uw	1705	30	acetylglucosaminidase	acetylglucosaminidase	NNP
cord-001835-0s7ok4uw	1705	31	(	(	-LRB-
cord-001835-0s7ok4uw	1705	32	so	so	RB
cord-001835-0s7ok4uw	1705	33	-	-	HYPH
cord-001835-0s7ok4uw	1705	34	called	call	VBN
cord-001835-0s7ok4uw	1705	35	VhGlcNAcase	vhglcnacase	NN
cord-001835-0s7ok4uw	1705	36	)	)	-RRB-
cord-001835-0s7ok4uw	1705	37	is	be	VBZ
cord-001835-0s7ok4uw	1705	38	a	a	DT
cord-001835-0s7ok4uw	1705	39	new	new	JJ
cord-001835-0s7ok4uw	1705	40	member	member	NN
cord-001835-0s7ok4uw	1705	41	of	of	IN
cord-001835-0s7ok4uw	1705	42	the	the	DT
cord-001835-0s7ok4uw	1705	43	GH20	GH20	NNP
cord-001835-0s7ok4uw	1705	44	glycoside	glycoside	NN
cord-001835-0s7ok4uw	1705	45	hydrolase	hydrolase	NN
cord-001835-0s7ok4uw	1705	46	family	family	NN
cord-001835-0s7ok4uw	1705	47	responsible	responsible	JJ
cord-001835-0s7ok4uw	1705	48	for	for	IN
cord-001835-0s7ok4uw	1705	49	the	the	DT
cord-001835-0s7ok4uw	1705	50	complete	complete	JJ
cord-001835-0s7ok4uw	1705	51	degradation	degradation	NN
cord-001835-0s7ok4uw	1705	52	of	of	IN
cord-001835-0s7ok4uw	1705	53	chitin	chitin	NN
cord-001835-0s7ok4uw	1705	54	fragments	fragment	NNS
cord-001835-0s7ok4uw	1705	55	,	,	,
cord-001835-0s7ok4uw	1705	56	with	with	IN
cord-001835-0s7ok4uw	1705	57	Nacetylglucosamine	Nacetylglucosamine	NNP
cord-001835-0s7ok4uw	1705	58	(	(	-LRB-
cord-001835-0s7ok4uw	1705	59	GlcNAc	GlcNAc	NNP
cord-001835-0s7ok4uw	1705	60	)	)	-RRB-
cord-001835-0s7ok4uw	1705	61	monomers	monomer	NNS
cord-001835-0s7ok4uw	1705	62	as	as	IN
cord-001835-0s7ok4uw	1705	63	the	the	DT
cord-001835-0s7ok4uw	1705	64	final	final	JJ
cord-001835-0s7ok4uw	1705	65	products	product	NNS
cord-001835-0s7ok4uw	1705	66	.	.	.
cord-001835-0s7ok4uw	1706	1	However	however	RB
cord-001835-0s7ok4uw	1706	2	,	,	,
cord-001835-0s7ok4uw	1706	3	the	the	DT
cord-001835-0s7ok4uw	1706	4	3D	3d	JJ
cord-001835-0s7ok4uw	1706	5	structure	structure	NN
cord-001835-0s7ok4uw	1706	6	of	of	IN
cord-001835-0s7ok4uw	1706	7	GlcNAcase	glcnacase	NN
cord-001835-0s7ok4uw	1706	8	is	be	VBZ
cord-001835-0s7ok4uw	1706	9	still	still	RB
cord-001835-0s7ok4uw	1706	10	unknown	unknown	JJ
cord-001835-0s7ok4uw	1706	11	.	.	.
cord-001835-0s7ok4uw	1707	1	In	in	IN
cord-001835-0s7ok4uw	1707	2	this	this	DT
cord-001835-0s7ok4uw	1707	3	study	study	NN
cord-001835-0s7ok4uw	1707	4	,	,	,
cord-001835-0s7ok4uw	1707	5	crystal	crystal	NN
cord-001835-0s7ok4uw	1707	6	structure	structure	NN
cord-001835-0s7ok4uw	1707	7	and	and	CC
cord-001835-0s7ok4uw	1707	8	function	function	NN
cord-001835-0s7ok4uw	1707	9	of	of	IN
cord-001835-0s7ok4uw	1707	10	GlcNAcase	glcnacase	NN
cord-001835-0s7ok4uw	1707	11	were	be	VBD
cord-001835-0s7ok4uw	1707	12	investigated	investigate	VBN
cord-001835-0s7ok4uw	1707	13	based	base	VBN
cord-001835-0s7ok4uw	1707	14	on	on	IN
cord-001835-0s7ok4uw	1707	15	protein	protein	NN
cord-001835-0s7ok4uw	1707	16	crystallography	crystallography	NN
cord-001835-0s7ok4uw	1707	17	.	.	.
cord-001835-0s7ok4uw	1708	1	Size	size	NN
cord-001835-0s7ok4uw	1708	2	-	-	HYPH
cord-001835-0s7ok4uw	1708	3	exclusion	exclusion	NN
cord-001835-0s7ok4uw	1708	4	chromatography	chromatography	NN
cord-001835-0s7ok4uw	1708	5	and	and	CC
cord-001835-0s7ok4uw	1708	6	the	the	DT
cord-001835-0s7ok4uw	1708	7	Native	Native	NNP
cord-001835-0s7ok4uw	1708	8	-	-	HYPH
cord-001835-0s7ok4uw	1708	9	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	1708	10	were	be	VBD
cord-001835-0s7ok4uw	1708	11	employed	employ	VBN
cord-001835-0s7ok4uw	1708	12	to	to	TO
cord-001835-0s7ok4uw	1708	13	verify	verify	VB
cord-001835-0s7ok4uw	1708	14	the	the	DT
cord-001835-0s7ok4uw	1708	15	protein	protein	NN
cord-001835-0s7ok4uw	1708	16	state	state	NN
cord-001835-0s7ok4uw	1708	17	of	of	IN
cord-001835-0s7ok4uw	1708	18	GlcNAcase	glcnacase	NN
cord-001835-0s7ok4uw	1708	19	in	in	IN
cord-001835-0s7ok4uw	1708	20	a	a	DT
cord-001835-0s7ok4uw	1708	21	native	native	JJ
cord-001835-0s7ok4uw	1708	22	form	form	NN
cord-001835-0s7ok4uw	1708	23	and	and	CC
cord-001835-0s7ok4uw	1708	24	the	the	DT
cord-001835-0s7ok4uw	1708	25	acidic	acidic	JJ
cord-001835-0s7ok4uw	1708	26	active	active	JJ
cord-001835-0s7ok4uw	1708	27	-	-	HYPH
cord-001835-0s7ok4uw	1708	28	site	site	NN
cord-001835-0s7ok4uw	1708	29	residues	residue	NNS
cord-001835-0s7ok4uw	1708	30	were	be	VBD
cord-001835-0s7ok4uw	1708	31	mutated	mutate	VBN
cord-001835-0s7ok4uw	1708	32	using	use	VBG
cord-001835-0s7ok4uw	1708	33	sitedirected	sitedirected	JJ
cord-001835-0s7ok4uw	1708	34	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	1708	35	method	method	NN
cord-001835-0s7ok4uw	1708	36	.	.	.
cord-001835-0s7ok4uw	1709	1	The	the	DT
cord-001835-0s7ok4uw	1709	2	effects	effect	NNS
cord-001835-0s7ok4uw	1709	3	of	of	IN
cord-001835-0s7ok4uw	1709	4	mutations	mutation	NNS
cord-001835-0s7ok4uw	1709	5	on	on	IN
cord-001835-0s7ok4uw	1709	6	the	the	DT
cord-001835-0s7ok4uw	1709	7	binding	binding	JJ
cord-001835-0s7ok4uw	1709	8	and	and	CC
cord-001835-0s7ok4uw	1709	9	hydrolytic	hydrolytic	JJ
cord-001835-0s7ok4uw	1709	10	activities	activity	NNS
cord-001835-0s7ok4uw	1709	11	were	be	VBD
cord-001835-0s7ok4uw	1709	12	studied	study	VBN
cord-001835-0s7ok4uw	1709	13	by	by	IN
cord-001835-0s7ok4uw	1709	14	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1709	15	kinetics	kinetics	NN
cord-001835-0s7ok4uw	1709	16	.	.	.
cord-001835-0s7ok4uw	1710	1	To	to	TO
cord-001835-0s7ok4uw	1710	2	provide	provide	VB
cord-001835-0s7ok4uw	1710	3	a	a	DT
cord-001835-0s7ok4uw	1710	4	structural	structural	JJ
cord-001835-0s7ok4uw	1710	5	basis	basis	NN
cord-001835-0s7ok4uw	1710	6	of	of	IN
cord-001835-0s7ok4uw	1710	7	GlcNAcase	glcnacase	NN
cord-001835-0s7ok4uw	1710	8	,	,	,
cord-001835-0s7ok4uw	1710	9	the	the	DT
cord-001835-0s7ok4uw	1710	10	wild	wild	JJ
cord-001835-0s7ok4uw	1710	11	-	-	HYPH
cord-001835-0s7ok4uw	1710	12	type	type	NN
cord-001835-0s7ok4uw	1710	13	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1710	14	was	be	VBD
cord-001835-0s7ok4uw	1710	15	crystalized	crystalize	VBN
cord-001835-0s7ok4uw	1710	16	at	at	IN
cord-001835-0s7ok4uw	1710	17	293	293	CD
cord-001835-0s7ok4uw	1710	18	K	k	NN
cord-001835-0s7ok4uw	1710	19	using	use	VBG
cord-001835-0s7ok4uw	1710	20	a	a	DT
cord-001835-0s7ok4uw	1710	21	solution	solution	NN
cord-001835-0s7ok4uw	1710	22	containing	contain	VBG
cord-001835-0s7ok4uw	1710	23	0.1	0.1	CD
cord-001835-0s7ok4uw	1710	24	M	M	NNP
cord-001835-0s7ok4uw	1710	25	sodium	sodium	NN
cord-001835-0s7ok4uw	1710	26	acetate	acetate	NN
cord-001835-0s7ok4uw	1710	27	pH	pH	NNP
cord-001835-0s7ok4uw	1710	28	4.6	4.6	CD
cord-001835-0s7ok4uw	1710	29	and	and	CC
cord-001835-0s7ok4uw	1710	30	1.3	1.3	CD
cord-001835-0s7ok4uw	1710	31	M	m	NN
cord-001835-0s7ok4uw	1710	32	sodium	sodium	NN
cord-001835-0s7ok4uw	1710	33	malonate	malonate	NN
cord-001835-0s7ok4uw	1710	34	and	and	CC
cord-001835-0s7ok4uw	1710	35	recorded	recorded	JJ
cord-001835-0s7ok4uw	1710	36	X	x	NN
cord-001835-0s7ok4uw	1710	37	-	-	NN
cord-001835-0s7ok4uw	1710	38	ray	ray	NN
cord-001835-0s7ok4uw	1710	39	data	datum	NNS
cord-001835-0s7ok4uw	1710	40	.	.	.
cord-001835-0s7ok4uw	1711	1	The	the	DT
cord-001835-0s7ok4uw	1711	2	wild	wild	JJ
cord-001835-0s7ok4uw	1711	3	-	-	HYPH
cord-001835-0s7ok4uw	1711	4	type	type	NN
cord-001835-0s7ok4uw	1711	5	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1711	6	was	be	VBD
cord-001835-0s7ok4uw	1711	7	crystallized	crystallize	VBN
cord-001835-0s7ok4uw	1711	8	within	within	IN
cord-001835-0s7ok4uw	1711	9	3	3	CD
cord-001835-0s7ok4uw	1711	10	days	day	NNS
cord-001835-0s7ok4uw	1711	11	in	in	IN
cord-001835-0s7ok4uw	1711	12	the	the	DT
cord-001835-0s7ok4uw	1711	13	monoclinic	monoclinic	JJ
cord-001835-0s7ok4uw	1711	14	crystal	crystal	NN
cord-001835-0s7ok4uw	1711	15	form	form	NN
cord-001835-0s7ok4uw	1711	16	,	,	,
cord-001835-0s7ok4uw	1711	17	belonging	belong	VBG
cord-001835-0s7ok4uw	1711	18	to	to	IN
cord-001835-0s7ok4uw	1711	19	space	space	NN
cord-001835-0s7ok4uw	1711	20	group	group	NN
cord-001835-0s7ok4uw	1711	21	P21	P21	NNP
cord-001835-0s7ok4uw	1711	22	,	,	,
cord-001835-0s7ok4uw	1711	23	with	with	IN
cord-001835-0s7ok4uw	1711	24	unit	unit	NN
cord-001835-0s7ok4uw	1711	25	-	-	HYPH
cord-001835-0s7ok4uw	1711	26	cell	cell	NN
cord-001835-0s7ok4uw	1711	27	parameters	parameter	NNS
cord-001835-0s7ok4uw	1711	28	a	a	DT
cord-001835-0s7ok4uw	1711	29	5	5	CD
cord-001835-0s7ok4uw	1711	30	90.2	90.2	CD
cord-001835-0s7ok4uw	1711	31	,	,	,
cord-001835-0s7ok4uw	1711	32	b	b	NN
cord-001835-0s7ok4uw	1711	33	5	5	CD
cord-001835-0s7ok4uw	1711	34	130.7	130.7	CD
cord-001835-0s7ok4uw	1711	35	,	,	,
cord-001835-0s7ok4uw	1711	36	c	c	NN
cord-001835-0s7ok4uw	1711	37	5	5	CD
cord-001835-0s7ok4uw	1711	38	98.5	98.5	CD
cord-001835-0s7ok4uw	1712	1	Å.	å.	NN
cord-001835-0s7ok4uw	1713	1	The	the	DT
cord-001835-0s7ok4uw	1713	2	crystal	crystal	NN
cord-001835-0s7ok4uw	1713	3	structures	structure	NNS
cord-001835-0s7ok4uw	1713	4	of	of	IN
cord-001835-0s7ok4uw	1713	5	V.	V.	NNP
cord-001835-0s7ok4uw	1713	6	harveyi	harveyi	NNP
cord-001835-0s7ok4uw	1713	7	GlcNAcase	GlcNAcase	NNP
cord-001835-0s7ok4uw	1713	8	were	be	VBD
cord-001835-0s7ok4uw	1713	9	solved	solve	VBN
cord-001835-0s7ok4uw	1713	10	and	and	CC
cord-001835-0s7ok4uw	1713	11	refined	refine	VBN
cord-001835-0s7ok4uw	1713	12	to	to	IN
cord-001835-0s7ok4uw	1713	13	highest	high	JJS
cord-001835-0s7ok4uw	1713	14	resolution	resolution	NN
cord-001835-0s7ok4uw	1713	15	of	of	IN
cord-001835-0s7ok4uw	1713	16	2.4	2.4	CD
cord-001835-0s7ok4uw	1713	17	Å.	Å.	NNP
cord-001835-0s7ok4uw	1713	18	Structural	Structural	NNP
cord-001835-0s7ok4uw	1713	19	investigation	investigation	NN
cord-001835-0s7ok4uw	1713	20	revealed	reveal	VBD
cord-001835-0s7ok4uw	1713	21	that	that	IN
cord-001835-0s7ok4uw	1713	22	GlcNAcase	glcnacase	NN
cord-001835-0s7ok4uw	1713	23	comprises	comprise	VBZ
cord-001835-0s7ok4uw	1713	24	three	three	CD
cord-001835-0s7ok4uw	1713	25	distinct	distinct	JJ
cord-001835-0s7ok4uw	1713	26	domains	domain	NNS
cord-001835-0s7ok4uw	1713	27	,	,	,
cord-001835-0s7ok4uw	1713	28	designated	designate	VBN
cord-001835-0s7ok4uw	1713	29	as	as	IN
cord-001835-0s7ok4uw	1713	30	the	the	DT
cord-001835-0s7ok4uw	1713	31	N	n	CD
cord-001835-0s7ok4uw	1713	32	-	-	HYPH
cord-001835-0s7ok4uw	1713	33	terminal	terminal	NN
cord-001835-0s7ok4uw	1713	34	carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	1713	35	-	-	HYPH
cord-001835-0s7ok4uw	1713	36	binding	bind	VBG
cord-001835-0s7ok4uw	1713	37	domain	domain	NN
cord-001835-0s7ok4uw	1713	38	,	,	,
cord-001835-0s7ok4uw	1713	39	the	the	DT
cord-001835-0s7ok4uw	1713	40	a1b	a1b	NN
cord-001835-0s7ok4uw	1713	41	topology	topology	NN
cord-001835-0s7ok4uw	1713	42	domain	domain	NN
cord-001835-0s7ok4uw	1713	43	and	and	CC
cord-001835-0s7ok4uw	1713	44	the	the	DT
cord-001835-0s7ok4uw	1713	45	TIM	TIM	NNP
cord-001835-0s7ok4uw	1713	46	-	-	HYPH
cord-001835-0s7ok4uw	1713	47	barrel	barrel	NN
cord-001835-0s7ok4uw	1713	48	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1713	49	domain	domain	NN
cord-001835-0s7ok4uw	1713	50	.	.	.
cord-001835-0s7ok4uw	1714	1	The	the	DT
cord-001835-0s7ok4uw	1714	2	substrate	substrate	NN
cord-001835-0s7ok4uw	1714	3	binding	bind	VBG
cord-001835-0s7ok4uw	1714	4	groove	groove	NN
cord-001835-0s7ok4uw	1714	5	of	of	IN
cord-001835-0s7ok4uw	1714	6	GlcNAcase	glcnacase	NN
cord-001835-0s7ok4uw	1714	7	is	be	VBZ
cord-001835-0s7ok4uw	1714	8	a	a	DT
cord-001835-0s7ok4uw	1714	9	small	small	JJ
cord-001835-0s7ok4uw	1714	10	pocket	pocket	NN
cord-001835-0s7ok4uw	1714	11	,	,	,
cord-001835-0s7ok4uw	1714	12	which	which	WDT
cord-001835-0s7ok4uw	1714	13	is	be	VBZ
cord-001835-0s7ok4uw	1714	14	suitable	suitable	JJ
cord-001835-0s7ok4uw	1714	15	to	to	TO
cord-001835-0s7ok4uw	1714	16	accommodate	accommodate	VB
cord-001835-0s7ok4uw	1714	17	a	a	DT
cord-001835-0s7ok4uw	1714	18	shortchain	shortchain	NN
cord-001835-0s7ok4uw	1714	19	chitooligosaccharide	chitooligosaccharide	NN
cord-001835-0s7ok4uw	1714	20	.	.	.
cord-001835-0s7ok4uw	1715	1	Kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1715	2	analysis	analysis	NN
cord-001835-0s7ok4uw	1715	3	revealed	reveal	VBD
cord-001835-0s7ok4uw	1715	4	that	that	IN
cord-001835-0s7ok4uw	1715	5	a	a	DT
cord-001835-0s7ok4uw	1715	6	group	group	NN
cord-001835-0s7ok4uw	1715	7	of	of	IN
cord-001835-0s7ok4uw	1715	8	the	the	DT
cord-001835-0s7ok4uw	1715	9	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	1715	10	D303-H373-E438	D303-H373-E438	NNP
cord-001835-0s7ok4uw	1715	11	showed	show	VBD
cord-001835-0s7ok4uw	1715	12	a	a	DT
cord-001835-0s7ok4uw	1715	13	significantly	significantly	RB
cord-001835-0s7ok4uw	1715	14	decreased	decrease	VBN
cord-001835-0s7ok4uw	1715	15	activity	activity	NN
cord-001835-0s7ok4uw	1715	16	as	as	IN
cord-001835-0s7ok4uw	1715	17	compared	compare	VBN
cord-001835-0s7ok4uw	1715	18	with	with	IN
cord-001835-0s7ok4uw	1715	19	the	the	DT
cord-001835-0s7ok4uw	1715	20	wild	wild	JJ
cord-001835-0s7ok4uw	1715	21	-	-	HYPH
cord-001835-0s7ok4uw	1715	22	type	type	NN
cord-001835-0s7ok4uw	1715	23	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1715	24	,	,	,
cord-001835-0s7ok4uw	1715	25	and	and	CC
cord-001835-0s7ok4uw	1715	26	these	these	DT
cord-001835-0s7ok4uw	1715	27	residues	residue	NNS
cord-001835-0s7ok4uw	1715	28	might	may	MD
cord-001835-0s7ok4uw	1715	29	be	be	VB
cord-001835-0s7ok4uw	1715	30	important	important	JJ
cord-001835-0s7ok4uw	1715	31	for	for	IN
cord-001835-0s7ok4uw	1715	32	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1715	33	catalysis	catalysis	NN
cord-001835-0s7ok4uw	1715	34	.	.	.
cord-001835-0s7ok4uw	1716	1	Silencing	silence	VBG
cord-001835-0s7ok4uw	1716	2	the	the	DT
cord-001835-0s7ok4uw	1716	3	molecular	molecular	JJ
cord-001835-0s7ok4uw	1716	4	timekeeper	timekeeper	NN
cord-001835-0s7ok4uw	1716	5	in	in	IN
cord-001835-0s7ok4uw	1716	6	human	human	JJ
cord-001835-0s7ok4uw	1716	7	cancer	cancer	NN
cord-001835-0s7ok4uw	1716	8	Alicia	Alicia	NNP
cord-001835-0s7ok4uw	1716	9	Michael	Michael	NNP
cord-001835-0s7ok4uw	1716	10	1	1	CD
cord-001835-0s7ok4uw	1716	11	,	,	,
cord-001835-0s7ok4uw	1716	12	Stacy	Stacy	NNP
cord-001835-0s7ok4uw	1716	13	Harvey	Harvey	NNP
cord-001835-0s7ok4uw	1716	14	1	1	CD
cord-001835-0s7ok4uw	1716	15	,	,	,
cord-001835-0s7ok4uw	1716	16	Patrick	Patrick	NNP
cord-001835-0s7ok4uw	1716	17	Sammons	Sammons	NNP
cord-001835-0s7ok4uw	1716	18	1	1	CD
cord-001835-0s7ok4uw	1716	19	,	,	,
cord-001835-0s7ok4uw	1716	20	Amanda	Amanda	NNP
cord-001835-0s7ok4uw	1716	21	Anderson	Anderson	NNP
cord-001835-0s7ok4uw	1716	22	2	2	CD
cord-001835-0s7ok4uw	1716	23	,	,	,
cord-001835-0s7ok4uw	1716	24	Hema	Hema	NNP
cord-001835-0s7ok4uw	1716	25	Kopalle	Kopalle	NNP
cord-001835-0s7ok4uw	1716	26	1	1	CD
cord-001835-0s7ok4uw	1716	27	,	,	,
cord-001835-0s7ok4uw	1716	28	Alison	Alison	NNP
cord-001835-0s7ok4uw	1716	29	Banham	Banham	NNP
cord-001835-0s7ok4uw	1716	30	2	2	CD
cord-001835-0s7ok4uw	1716	31	,	,	,
cord-001835-0s7ok4uw	1716	32	Carrie	Carrie	NNP
cord-001835-0s7ok4uw	1716	33	Partch	Partch	NNP
cord-001835-0s7ok4uw	1716	34	1	1	CD
cord-001835-0s7ok4uw	1716	35	1	1	CD
cord-001835-0s7ok4uw	1716	36	University	University	NNP
cord-001835-0s7ok4uw	1716	37	of	of	IN
cord-001835-0s7ok4uw	1716	38	California	California	NNP
cord-001835-0s7ok4uw	1716	39	-Santa	-Santa	NNP
cord-001835-0s7ok4uw	1716	40	Cruz	Cruz	NNP
cord-001835-0s7ok4uw	1716	41	,	,	,
cord-001835-0s7ok4uw	1716	42	2	2	CD
cord-001835-0s7ok4uw	1716	43	University	University	NNP
cord-001835-0s7ok4uw	1716	44	of	of	IN
cord-001835-0s7ok4uw	1716	45	Oxford	Oxford	NNP
cord-001835-0s7ok4uw	1716	46	The	the	DT
cord-001835-0s7ok4uw	1716	47	circadian	circadian	NN
cord-001835-0s7ok4uw	1716	48	clock	clock	NN
cord-001835-0s7ok4uw	1716	49	coordinates	coordinate	VBZ
cord-001835-0s7ok4uw	1716	50	temporal	temporal	JJ
cord-001835-0s7ok4uw	1716	51	control	control	NN
cord-001835-0s7ok4uw	1716	52	of	of	IN
cord-001835-0s7ok4uw	1716	53	physiology	physiology	NN
cord-001835-0s7ok4uw	1716	54	by	by	IN
cord-001835-0s7ok4uw	1716	55	regulating	regulate	VBG
cord-001835-0s7ok4uw	1716	56	the	the	DT
cord-001835-0s7ok4uw	1716	57	expression	expression	NN
cord-001835-0s7ok4uw	1716	58	of	of	IN
cord-001835-0s7ok4uw	1716	59	at	at	RB
cord-001835-0s7ok4uw	1716	60	least	least	RBS
cord-001835-0s7ok4uw	1716	61	40	40	CD
cord-001835-0s7ok4uw	1716	62	%	%	NN
cord-001835-0s7ok4uw	1716	63	of	of	IN
cord-001835-0s7ok4uw	1716	64	the	the	DT
cord-001835-0s7ok4uw	1716	65	genome	genome	NN
cord-001835-0s7ok4uw	1716	66	on	on	IN
cord-001835-0s7ok4uw	1716	67	a	a	DT
cord-001835-0s7ok4uw	1716	68	daily	daily	JJ
cord-001835-0s7ok4uw	1716	69	basis.1	basis.1	JJ
cord-001835-0s7ok4uw	1716	70	Disruption	disruption	NN
cord-001835-0s7ok4uw	1716	71	of	of	IN
cord-001835-0s7ok4uw	1716	72	circadian	circadian	NN
cord-001835-0s7ok4uw	1716	73	rhythms	rhythm	NNS
cord-001835-0s7ok4uw	1716	74	through	through	IN
cord-001835-0s7ok4uw	1716	75	environmental	environmental	JJ
cord-001835-0s7ok4uw	1716	76	stimuli	stimulus	NNS
cord-001835-0s7ok4uw	1716	77	(	(	-LRB-
cord-001835-0s7ok4uw	1716	78	e.g.	e.g.	RB
cord-001835-0s7ok4uw	1716	79	light	light	NN
cord-001835-0s7ok4uw	1716	80	at	at	IN
cord-001835-0s7ok4uw	1716	81	night	night	NN
cord-001835-0s7ok4uw	1716	82	)	)	-RRB-
cord-001835-0s7ok4uw	1716	83	or	or	CC
cord-001835-0s7ok4uw	1716	84	genetic	genetic	JJ
cord-001835-0s7ok4uw	1716	85	means	mean	NNS
cord-001835-0s7ok4uw	1716	86	can	can	MD
cord-001835-0s7ok4uw	1716	87	lead	lead	VB
cord-001835-0s7ok4uw	1716	88	to	to	IN
cord-001835-0s7ok4uw	1716	89	the	the	DT
cord-001835-0s7ok4uw	1716	90	onset	onset	NN
cord-001835-0s7ok4uw	1716	91	of	of	IN
cord-001835-0s7ok4uw	1716	92	diseases	disease	NNS
cord-001835-0s7ok4uw	1716	93	such	such	JJ
cord-001835-0s7ok4uw	1716	94	as	as	IN
cord-001835-0s7ok4uw	1716	95	:	:	:
cord-001835-0s7ok4uw	1716	96	diabetes	diabetes	NN
cord-001835-0s7ok4uw	1716	97	,	,	,
cord-001835-0s7ok4uw	1716	98	cardiovascular	cardiovascular	JJ
cord-001835-0s7ok4uw	1716	99	disease	disease	NN
cord-001835-0s7ok4uw	1716	100	,	,	,
cord-001835-0s7ok4uw	1716	101	premature	premature	JJ
cord-001835-0s7ok4uw	1716	102	aging	aging	NN
cord-001835-0s7ok4uw	1716	103	and	and	CC
cord-001835-0s7ok4uw	1716	104	cancer.2	cancer.2	NN
cord-001835-0s7ok4uw	1716	105	-	-	HYPH
cord-001835-0s7ok4uw	1716	106	5	5	CD
cord-001835-0s7ok4uw	1717	1	The	the	DT
cord-001835-0s7ok4uw	1717	2	circadian	circadian	NN
cord-001835-0s7ok4uw	1717	3	clock	clock	NN
cord-001835-0s7ok4uw	1717	4	orchestrates	orchestrate	VBZ
cord-001835-0s7ok4uw	1717	5	global	global	JJ
cord-001835-0s7ok4uw	1717	6	changes	change	NNS
cord-001835-0s7ok4uw	1717	7	in	in	IN
cord-001835-0s7ok4uw	1717	8	transcriptional	transcriptional	JJ
cord-001835-0s7ok4uw	1717	9	regulation	regulation	NN
cord-001835-0s7ok4uw	1717	10	via	via	IN
cord-001835-0s7ok4uw	1717	11	the	the	DT
cord-001835-0s7ok4uw	1717	12	bHLH	bhlh	JJ
cord-001835-0s7ok4uw	1717	13	-	-	HYPH
cord-001835-0s7ok4uw	1717	14	PAS	pas	NN
cord-001835-0s7ok4uw	1717	15	transcription	transcription	NN
cord-001835-0s7ok4uw	1717	16	factor	factor	NN
cord-001835-0s7ok4uw	1717	17	CLOCK	clock	NN
cord-001835-0s7ok4uw	1717	18	:	:	:
cord-001835-0s7ok4uw	1718	1	BMAL1	BMAL1	NNP
cord-001835-0s7ok4uw	1718	2	.	.	.
cord-001835-0s7ok4uw	1719	1	Pathways	pathway	NNS
cord-001835-0s7ok4uw	1719	2	driven	drive	VBN
cord-001835-0s7ok4uw	1719	3	by	by	IN
cord-001835-0s7ok4uw	1719	4	other	other	JJ
cord-001835-0s7ok4uw	1719	5	bHLH	bhlh	JJ
cord-001835-0s7ok4uw	1719	6	-	-	HYPH
cord-001835-0s7ok4uw	1719	7	PAS	pas	NN
cord-001835-0s7ok4uw	1719	8	transcription	transcription	NN
cord-001835-0s7ok4uw	1719	9	factors	factor	NNS
cord-001835-0s7ok4uw	1719	10	have	have	VBP
cord-001835-0s7ok4uw	1719	11	a	a	DT
cord-001835-0s7ok4uw	1719	12	homologous	homologous	JJ
cord-001835-0s7ok4uw	1719	13	repressor	repressor	NN
cord-001835-0s7ok4uw	1719	14	that	that	WDT
cord-001835-0s7ok4uw	1719	15	modulates	modulate	VBZ
cord-001835-0s7ok4uw	1719	16	activity	activity	NN
cord-001835-0s7ok4uw	1719	17	on	on	IN
cord-001835-0s7ok4uw	1719	18	a	a	DT
cord-001835-0s7ok4uw	1719	19	tissue	tissue	NN
cord-001835-0s7ok4uw	1719	20	-	-	HYPH
cord-001835-0s7ok4uw	1719	21	specific	specific	JJ
cord-001835-0s7ok4uw	1719	22	basis	basis	NN
cord-001835-0s7ok4uw	1719	23	,	,	,
cord-001835-0s7ok4uw	1719	24	but	but	CC
cord-001835-0s7ok4uw	1719	25	none	none	NN
cord-001835-0s7ok4uw	1719	26	have	have	VBP
cord-001835-0s7ok4uw	1719	27	been	be	VBN
cord-001835-0s7ok4uw	1719	28	identified	identify	VBN
cord-001835-0s7ok4uw	1719	29	for	for	IN
cord-001835-0s7ok4uw	1719	30	CLOCK	clock	NN
cord-001835-0s7ok4uw	1719	31	:	:	:
cord-001835-0s7ok4uw	1720	1	BMAL1	BMAL1	NNP
cord-001835-0s7ok4uw	1720	2	.	.	.
cord-001835-0s7ok4uw	1721	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1721	2	discovered	discover	VBD
cord-001835-0s7ok4uw	1721	3	that	that	IN
cord-001835-0s7ok4uw	1721	4	the	the	DT
cord-001835-0s7ok4uw	1721	5	cancer	cancer	NN
cord-001835-0s7ok4uw	1721	6	/	/	SYM
cord-001835-0s7ok4uw	1721	7	testis	testis	NN
cord-001835-0s7ok4uw	1721	8	antigen	antigen	NN
cord-001835-0s7ok4uw	1721	9	PASD1	PASD1	NNP
cord-001835-0s7ok4uw	1721	10	fulfills	fulfill	VBZ
cord-001835-0s7ok4uw	1721	11	this	this	DT
cord-001835-0s7ok4uw	1721	12	role	role	NN
cord-001835-0s7ok4uw	1721	13	to	to	TO
cord-001835-0s7ok4uw	1721	14	suppress	suppress	VB
cord-001835-0s7ok4uw	1721	15	circadian	circadian	NN
cord-001835-0s7ok4uw	1721	16	rhythms	rhythm	NNS
cord-001835-0s7ok4uw	1721	17	.	.	.
cord-001835-0s7ok4uw	1722	1	PASD1	PASD1	NNP
cord-001835-0s7ok4uw	1722	2	is	be	VBZ
cord-001835-0s7ok4uw	1722	3	evolutionarily	evolutionarily	RB
cord-001835-0s7ok4uw	1722	4	related	related	JJ
cord-001835-0s7ok4uw	1722	5	to	to	IN
cord-001835-0s7ok4uw	1722	6	CLOCK	clock	NN
cord-001835-0s7ok4uw	1722	7	and	and	CC
cord-001835-0s7ok4uw	1722	8	interacts	interact	VBZ
cord-001835-0s7ok4uw	1722	9	with	with	IN
cord-001835-0s7ok4uw	1722	10	the	the	DT
cord-001835-0s7ok4uw	1722	11	CLOCK	clock	NN
cord-001835-0s7ok4uw	1722	12	:	:	:
cord-001835-0s7ok4uw	1723	1	BMAL1	BMAL1	NNP
cord-001835-0s7ok4uw	1723	2	complex	complex	NNP
cord-001835-0s7ok4uw	1724	1	to	to	TO
cord-001835-0s7ok4uw	1724	2	repress	repress	VB
cord-001835-0s7ok4uw	1724	3	transcriptional	transcriptional	JJ
cord-001835-0s7ok4uw	1724	4	activation	activation	NN
cord-001835-0s7ok4uw	1724	5	.	.	.
cord-001835-0s7ok4uw	1725	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1725	2	,	,	,
cord-001835-0s7ok4uw	1725	3	deletion	deletion	NN
cord-001835-0s7ok4uw	1725	4	of	of	IN
cord-001835-0s7ok4uw	1725	5	one	one	CD
cord-001835-0s7ok4uw	1725	6	region	region	NN
cord-001835-0s7ok4uw	1725	7	,	,	,
cord-001835-0s7ok4uw	1725	8	highly	highly	RB
cord-001835-0s7ok4uw	1725	9	conserved	conserve	VBN
cord-001835-0s7ok4uw	1725	10	with	with	IN
cord-001835-0s7ok4uw	1725	11	CLOCK	CLOCK	NNP
cord-001835-0s7ok4uw	1725	12	Exon	Exon	NNP
cord-001835-0s7ok4uw	1725	13	19	19	CD
cord-001835-0s7ok4uw	1725	14	,	,	,
cord-001835-0s7ok4uw	1725	15	alleviates	alleviate	VBZ
cord-001835-0s7ok4uw	1725	16	repression	repression	NN
cord-001835-0s7ok4uw	1725	17	by	by	IN
cord-001835-0s7ok4uw	1725	18	PASD1	PASD1	NNS
cord-001835-0s7ok4uw	1725	19	to	to	TO
cord-001835-0s7ok4uw	1725	20	suggest	suggest	VB
cord-001835-0s7ok4uw	1725	21	that	that	IN
cord-001835-0s7ok4uw	1725	22	it	-PRON-	PRP
cord-001835-0s7ok4uw	1725	23	utilizes	utilize	VBZ
cord-001835-0s7ok4uw	1725	24	molecular	molecular	JJ
cord-001835-0s7ok4uw	1725	25	mimicry	mimicry	NN
cord-001835-0s7ok4uw	1725	26	to	to	TO
cord-001835-0s7ok4uw	1725	27	interfere	interfere	VB
cord-001835-0s7ok4uw	1725	28	with	with	IN
cord-001835-0s7ok4uw	1725	29	CLOCK	clock	NN
cord-001835-0s7ok4uw	1725	30	:	:	:
cord-001835-0s7ok4uw	1726	1	BMAL1	BMAL1	NNP
cord-001835-0s7ok4uw	1726	2	function	function	NN
cord-001835-0s7ok4uw	1726	3	.	.	.
cord-001835-0s7ok4uw	1727	1	Structural	structural	JJ
cord-001835-0s7ok4uw	1727	2	and	and	CC
cord-001835-0s7ok4uw	1727	3	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	1727	4	studies	study	NNS
cord-001835-0s7ok4uw	1727	5	of	of	IN
cord-001835-0s7ok4uw	1727	6	the	the	DT
cord-001835-0s7ok4uw	1727	7	direct	direct	JJ
cord-001835-0s7ok4uw	1727	8	interaction	interaction	NN
cord-001835-0s7ok4uw	1727	9	of	of	IN
cord-001835-0s7ok4uw	1727	10	PASD1	PASD1	NNS
cord-001835-0s7ok4uw	1727	11	with	with	IN
cord-001835-0s7ok4uw	1727	12	the	the	DT
cord-001835-0s7ok4uw	1727	13	CLOCK	clock	NN
cord-001835-0s7ok4uw	1727	14	:	:	:
cord-001835-0s7ok4uw	1728	1	BMAL1	BMAL1	NNP
cord-001835-0s7ok4uw	1729	1	complex	complex	JJ
cord-001835-0s7ok4uw	1729	2	using	use	VBG
cord-001835-0s7ok4uw	1729	3	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1729	4	protein	protein	NN
cord-001835-0s7ok4uw	1729	5	expression	expression	NN
cord-001835-0s7ok4uw	1729	6	and	and	CC
cord-001835-0s7ok4uw	1729	7	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	1729	8	techniques	technique	NNS
cord-001835-0s7ok4uw	1729	9	are	be	VBP
cord-001835-0s7ok4uw	1729	10	currently	currently	RB
cord-001835-0s7ok4uw	1729	11	underway	underway	JJ
cord-001835-0s7ok4uw	1729	12	.	.	.
cord-001835-0s7ok4uw	1730	1	As	as	IN
cord-001835-0s7ok4uw	1730	2	a	a	DT
cord-001835-0s7ok4uw	1730	3	cancer	cancer	NN
cord-001835-0s7ok4uw	1730	4	/	/	SYM
cord-001835-0s7ok4uw	1730	5	testis	testis	NN
cord-001835-0s7ok4uw	1730	6	antigen	antigen	NN
cord-001835-0s7ok4uw	1730	7	,	,	,
cord-001835-0s7ok4uw	1730	8	expression	expression	NN
cord-001835-0s7ok4uw	1730	9	of	of	IN
cord-001835-0s7ok4uw	1730	10	PASD1	pasd1	NN
cord-001835-0s7ok4uw	1730	11	is	be	VBZ
cord-001835-0s7ok4uw	1730	12	natively	natively	RB
cord-001835-0s7ok4uw	1730	13	restricted	restrict	VBN
cord-001835-0s7ok4uw	1730	14	to	to	IN
cord-001835-0s7ok4uw	1730	15	gametogenic	gametogenic	JJ
cord-001835-0s7ok4uw	1730	16	tissues	tissue	NNS
cord-001835-0s7ok4uw	1730	17	but	but	CC
cord-001835-0s7ok4uw	1730	18	can	can	MD
cord-001835-0s7ok4uw	1730	19	be	be	VB
cord-001835-0s7ok4uw	1730	20	upregulated	upregulate	VBN
cord-001835-0s7ok4uw	1730	21	in	in	IN
cord-001835-0s7ok4uw	1730	22	somatic	somatic	JJ
cord-001835-0s7ok4uw	1730	23	tissues	tissue	NNS
cord-001835-0s7ok4uw	1730	24	as	as	IN
cord-001835-0s7ok4uw	1730	25	a	a	DT
cord-001835-0s7ok4uw	1730	26	consequence	consequence	NN
cord-001835-0s7ok4uw	1730	27	of	of	IN
cord-001835-0s7ok4uw	1730	28	oncogenic	oncogenic	JJ
cord-001835-0s7ok4uw	1730	29	transformation	transformation	NN
cord-001835-0s7ok4uw	1730	30	.	.	.
cord-001835-0s7ok4uw	1731	1	Reducing	reduce	VBG
cord-001835-0s7ok4uw	1731	2	PASD1	PASD1	NNS
cord-001835-0s7ok4uw	1731	3	in	in	IN
cord-001835-0s7ok4uw	1731	4	human	human	JJ
cord-001835-0s7ok4uw	1731	5	cancer	cancer	NN
cord-001835-0s7ok4uw	1731	6	cells	cell	NNS
cord-001835-0s7ok4uw	1731	7	significantly	significantly	RB
cord-001835-0s7ok4uw	1731	8	increases	increase	VBZ
cord-001835-0s7ok4uw	1731	9	the	the	DT
cord-001835-0s7ok4uw	1731	10	amplitude	amplitude	NN
cord-001835-0s7ok4uw	1731	11	of	of	IN
cord-001835-0s7ok4uw	1731	12	transcriptional	transcriptional	JJ
cord-001835-0s7ok4uw	1731	13	oscillations	oscillation	NNS
cord-001835-0s7ok4uw	1731	14	to	to	TO
cord-001835-0s7ok4uw	1731	15	generate	generate	VB
cord-001835-0s7ok4uw	1731	16	more	more	RBR
cord-001835-0s7ok4uw	1731	17	robust	robust	JJ
cord-001835-0s7ok4uw	1731	18	circadian	circadian	NN
cord-001835-0s7ok4uw	1731	19	rhythms	rhythm	NNS
cord-001835-0s7ok4uw	1731	20	.	.	.
cord-001835-0s7ok4uw	1732	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1732	2	work	work	NN
cord-001835-0s7ok4uw	1732	3	suggests	suggest	VBZ
cord-001835-0s7ok4uw	1732	4	that	that	IN
cord-001835-0s7ok4uw	1732	5	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1732	6	to	to	TO
cord-001835-0s7ok4uw	1732	7	suppress	suppress	VB
cord-001835-0s7ok4uw	1732	8	circadian	circadian	NN
cord-001835-0s7ok4uw	1732	9	cycling	cycling	NN
cord-001835-0s7ok4uw	1732	10	can	can	MD
cord-001835-0s7ok4uw	1732	11	be	be	VB
cord-001835-0s7ok4uw	1732	12	hard	hard	RB
cord-001835-0s7ok4uw	1732	13	-	-	HYPH
cord-001835-0s7ok4uw	1732	14	wired	wired	JJ
cord-001835-0s7ok4uw	1732	15	in	in	IN
cord-001835-0s7ok4uw	1732	16	a	a	DT
cord-001835-0s7ok4uw	1732	17	tissue	tissue	NN
cord-001835-0s7ok4uw	1732	18	-	-	HYPH
cord-001835-0s7ok4uw	1732	19	specific	specific	JJ
cord-001835-0s7ok4uw	1732	20	manner	manner	NN
cord-001835-0s7ok4uw	1732	21	and	and	CC
cord-001835-0s7ok4uw	1732	22	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1732	23	data	datum	NNS
cord-001835-0s7ok4uw	1732	24	show	show	VBP
cord-001835-0s7ok4uw	1732	25	that	that	IN
cord-001835-0s7ok4uw	1732	26	they	-PRON-	PRP
cord-001835-0s7ok4uw	1732	27	can	can	MD
cord-001835-0s7ok4uw	1732	28	be	be	VB
cord-001835-0s7ok4uw	1732	29	co	co	VBN
cord-001835-0s7ok4uw	1732	30	-	-	VBN
cord-001835-0s7ok4uw	1732	31	opted	opt	VBN
cord-001835-0s7ok4uw	1732	32	in	in	IN
cord-001835-0s7ok4uw	1732	33	cancer	cancer	NN
cord-001835-0s7ok4uw	1732	34	cells	cell	NNS
cord-001835-0s7ok4uw	1732	35	to	to	TO
cord-001835-0s7ok4uw	1732	36	attenuate	attenuate	VB
cord-001835-0s7ok4uw	1732	37	clock	clock	NN
cord-001835-0s7ok4uw	1732	38	function	function	NN
cord-001835-0s7ok4uw	1732	39	.	.	.
cord-001835-0s7ok4uw	1732	40	 	 	_SP
cord-001835-0s7ok4uw	1733	1	The	the	DT
cord-001835-0s7ok4uw	1733	2	scaffolding	scaffold	VBG
cord-001835-0s7ok4uw	1733	3	protein	protein	NN
cord-001835-0s7ok4uw	1733	4	IQGAP1	IQGAP1	NNP
cord-001835-0s7ok4uw	1733	5	participates	participate	VBZ
cord-001835-0s7ok4uw	1733	6	in	in	IN
cord-001835-0s7ok4uw	1733	7	various	various	JJ
cord-001835-0s7ok4uw	1733	8	cellular	cellular	JJ
cord-001835-0s7ok4uw	1733	9	functions	function	NNS
cord-001835-0s7ok4uw	1733	10	such	such	JJ
cord-001835-0s7ok4uw	1733	11	as	as	IN
cord-001835-0s7ok4uw	1733	12	cell	cell	NN
cord-001835-0s7ok4uw	1733	13	-	-	HYPH
cord-001835-0s7ok4uw	1733	14	cell	cell	NN
cord-001835-0s7ok4uw	1733	15	adhesion	adhesion	NN
cord-001835-0s7ok4uw	1733	16	,	,	,
cord-001835-0s7ok4uw	1733	17	cell	cell	NN
cord-001835-0s7ok4uw	1733	18	polarization	polarization	NN
cord-001835-0s7ok4uw	1733	19	and	and	CC
cord-001835-0s7ok4uw	1733	20	migration	migration	NN
cord-001835-0s7ok4uw	1733	21	,	,	,
cord-001835-0s7ok4uw	1733	22	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	1733	23	motility	motility	NN
cord-001835-0s7ok4uw	1733	24	,	,	,
cord-001835-0s7ok4uw	1733	25	and	and	CC
cord-001835-0s7ok4uw	1733	26	tumor	tumor	NN
cord-001835-0s7ok4uw	1733	27	cell	cell	NN
cord-001835-0s7ok4uw	1733	28	invasion	invasion	NN
cord-001835-0s7ok4uw	1733	29	by	by	IN
cord-001835-0s7ok4uw	1733	30	binding	bind	VBG
cord-001835-0s7ok4uw	1733	31	to	to	TO
cord-001835-0s7ok4uw	1733	32	target	target	VB
cord-001835-0s7ok4uw	1733	33	proteins	protein	NNS
cord-001835-0s7ok4uw	1733	34	,	,	,
cord-001835-0s7ok4uw	1733	35	including	include	VBG
cord-001835-0s7ok4uw	1733	36	Rac1	Rac1	NNP
cord-001835-0s7ok4uw	1733	37	and	and	CC
cord-001835-0s7ok4uw	1733	38	Cdc42	Cdc42	NNP
cord-001835-0s7ok4uw	1733	39	,	,	,
cord-001835-0s7ok4uw	1733	40	two	two	CD
cord-001835-0s7ok4uw	1733	41	members	member	NNS
cord-001835-0s7ok4uw	1733	42	of	of	IN
cord-001835-0s7ok4uw	1733	43	the	the	DT
cord-001835-0s7ok4uw	1733	44	Rho	Rho	NNP
cord-001835-0s7ok4uw	1733	45	family	family	NN
cord-001835-0s7ok4uw	1733	46	.	.	.
cord-001835-0s7ok4uw	1734	1	To	to	TO
cord-001835-0s7ok4uw	1734	2	better	well	RBR
cord-001835-0s7ok4uw	1734	3	understand	understand	VB
cord-001835-0s7ok4uw	1734	4	the	the	DT
cord-001835-0s7ok4uw	1734	5	molecular	molecular	JJ
cord-001835-0s7ok4uw	1734	6	basis	basis	NN
cord-001835-0s7ok4uw	1734	7	of	of	IN
cord-001835-0s7ok4uw	1734	8	these	these	DT
cord-001835-0s7ok4uw	1734	9	interactions	interaction	NNS
cord-001835-0s7ok4uw	1734	10	,	,	,
cord-001835-0s7ok4uw	1734	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	1734	12	utilized	utilize	VBD
cord-001835-0s7ok4uw	1734	13	in	in	IN
cord-001835-0s7ok4uw	1734	14	this	this	DT
cord-001835-0s7ok4uw	1734	15	study	study	NN
cord-001835-0s7ok4uw	1734	16	a	a	DT
cord-001835-0s7ok4uw	1734	17	novel	novel	JJ
cord-001835-0s7ok4uw	1734	18	time	time	NN
cord-001835-0s7ok4uw	1734	19	-	-	HYPH
cord-001835-0s7ok4uw	1734	20	resolved	resolve	VBN
cord-001835-0s7ok4uw	1734	21	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1734	22	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1734	23	to	to	TO
cord-001835-0s7ok4uw	1734	24	determine	determine	VB
cord-001835-0s7ok4uw	1734	25	individual	individual	JJ
cord-001835-0s7ok4uw	1734	26	rate	rate	NN
cord-001835-0s7ok4uw	1734	27	constants	constant	NNS
cord-001835-0s7ok4uw	1734	28	for	for	IN
cord-001835-0s7ok4uw	1734	29	IQGAP1	iqgap1	NN
cord-001835-0s7ok4uw	1734	30	interaction	interaction	NN
cord-001835-0s7ok4uw	1734	31	with	with	IN
cord-001835-0s7ok4uw	1734	32	fourteen	fourteen	CD
cord-001835-0s7ok4uw	1734	33	different	different	JJ
cord-001835-0s7ok4uw	1734	34	Rho	rho	NN
cord-001835-0s7ok4uw	1734	35	proteins	protein	NNS
cord-001835-0s7ok4uw	1734	36	.	.	.
cord-001835-0s7ok4uw	1735	1	The	the	DT
cord-001835-0s7ok4uw	1735	2	results	result	NNS
cord-001835-0s7ok4uw	1735	3	indicated	indicate	VBD
cord-001835-0s7ok4uw	1735	4	that	that	IN
cord-001835-0s7ok4uw	1735	5	IQGAP1	iqgap1	NN
cord-001835-0s7ok4uw	1735	6	binds	bind	VBZ
cord-001835-0s7ok4uw	1735	7	among	among	IN
cord-001835-0s7ok4uw	1735	8	Rho	rho	NN
cord-001835-0s7ok4uw	1735	9	proteins	protein	NNS
cord-001835-0s7ok4uw	1735	10	selectively	selectively	RB
cord-001835-0s7ok4uw	1735	11	to	to	IN
cord-001835-0s7ok4uw	1735	12	Rac	Rac	NNP
cord-001835-0s7ok4uw	1735	13	-	-	,
cord-001835-0s7ok4uw	1735	14	and	and	CC
cord-001835-0s7ok4uw	1735	15	Cdc42-like	cdc42-like	JJ
cord-001835-0s7ok4uw	1735	16	proteins	protein	NNS
cord-001835-0s7ok4uw	1735	17	only	only	RB
cord-001835-0s7ok4uw	1735	18	in	in	IN
cord-001835-0s7ok4uw	1735	19	a	a	DT
cord-001835-0s7ok4uw	1735	20	GTP	gtp	NN
cord-001835-0s7ok4uw	1735	21	-	-	HYPH
cord-001835-0s7ok4uw	1735	22	dependent	dependent	JJ
cord-001835-0s7ok4uw	1735	23	manner	manner	NN
cord-001835-0s7ok4uw	1735	24	.	.	.
cord-001835-0s7ok4uw	1736	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	1736	2	,	,	,
cord-001835-0s7ok4uw	1736	3	the	the	DT
cord-001835-0s7ok4uw	1736	4	interaction	interaction	NN
cord-001835-0s7ok4uw	1736	5	of	of	IN
cord-001835-0s7ok4uw	1736	6	Rho	rho	NN
cord-001835-0s7ok4uw	1736	7	proteins	protein	NNS
cord-001835-0s7ok4uw	1736	8	with	with	IN
cord-001835-0s7ok4uw	1736	9	the	the	DT
cord-001835-0s7ok4uw	1736	10	C	C	NNP
cord-001835-0s7ok4uw	1736	11	-	-	HYPH
cord-001835-0s7ok4uw	1736	12	terminal	terminal	NN
cord-001835-0s7ok4uw	1736	13	half	half	NN
cord-001835-0s7ok4uw	1736	14	of	of	IN
cord-001835-0s7ok4uw	1736	15	IQGAP1	iqgap1	NN
cord-001835-0s7ok4uw	1737	1	(	(	-LRB-
cord-001835-0s7ok4uw	1737	2	GRD	GRD	NNP
cord-001835-0s7ok4uw	1737	3	-	-	HYPH
cord-001835-0s7ok4uw	1737	4	C	C	NNP
cord-001835-0s7ok4uw	1737	5	)	)	-RRB-
cord-001835-0s7ok4uw	1737	6	,	,	,
cord-001835-0s7ok4uw	1737	7	shorter	short	JJR
cord-001835-0s7ok4uw	1737	8	fragment	fragment	NN
cord-001835-0s7ok4uw	1737	9	contains	contain	VBZ
cord-001835-0s7ok4uw	1737	10	GRD	GRD	NNP
cord-001835-0s7ok4uw	1737	11	-	-	HYPH
cord-001835-0s7ok4uw	1737	12	GBD	GBD	NNP
cord-001835-0s7ok4uw	1737	13	,	,	,
cord-001835-0s7ok4uw	1737	14	only	only	RB
cord-001835-0s7ok4uw	1737	15	the	the	DT
cord-001835-0s7ok4uw	1737	16	GRD	GRD	NNP
cord-001835-0s7ok4uw	1737	17	and	and	CC
cord-001835-0s7ok4uw	1737	18	also	also	RB
cord-001835-0s7ok4uw	1737	19	GRD	GRD	NNP
cord-001835-0s7ok4uw	1737	20	-	-	HYPH
cord-001835-0s7ok4uw	1737	21	GBD	GBD	NNP
cord-001835-0s7ok4uw	1737	22	with	with	IN
cord-001835-0s7ok4uw	1737	23	single	single	JJ
cord-001835-0s7ok4uw	1737	24	and	and	CC
cord-001835-0s7ok4uw	1737	25	double	double	JJ
cord-001835-0s7ok4uw	1737	26	phosphomimetic	phosphomimetic	JJ
cord-001835-0s7ok4uw	1737	27	mutations	mutation	NNS
cord-001835-0s7ok4uw	1738	1	S1441E	S1441E	NNP
cord-001835-0s7ok4uw	1739	1	and	and	CC
cord-001835-0s7ok4uw	1739	2	S1443D	S1443D	NNP
cord-001835-0s7ok4uw	1739	3	was	be	VBD
cord-001835-0s7ok4uw	1739	4	performed	perform	VBN
cord-001835-0s7ok4uw	1739	5	.	.	.
cord-001835-0s7ok4uw	1740	1	Obtained	obtain	VBN
cord-001835-0s7ok4uw	1740	2	results	result	NNS
cord-001835-0s7ok4uw	1740	3	showed	show	VBD
cord-001835-0s7ok4uw	1740	4	that	that	IN
cord-001835-0s7ok4uw	1740	5	,	,	,
cord-001835-0s7ok4uw	1740	6	when	when	WRB
cord-001835-0s7ok4uw	1740	7	both	both	CC
cord-001835-0s7ok4uw	1740	8	GRD	GRD	NNP
cord-001835-0s7ok4uw	1740	9	and	and	CC
cord-001835-0s7ok4uw	1740	10	GBD	GBD	NNP
cord-001835-0s7ok4uw	1740	11	are	be	VBP
cord-001835-0s7ok4uw	1740	12	existing	exist	VBG
cord-001835-0s7ok4uw	1740	13	,	,	,
cord-001835-0s7ok4uw	1740	14	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1740	15	changes	change	NNS
cord-001835-0s7ok4uw	1740	16	is	be	VBZ
cord-001835-0s7ok4uw	1740	17	detected	detect	VBN
cord-001835-0s7ok4uw	1740	18	but	but	CC
cord-001835-0s7ok4uw	1740	19	for	for	IN
cord-001835-0s7ok4uw	1740	20	GRD	GRD	NNP
cord-001835-0s7ok4uw	1740	21	alone	alone	RB
cord-001835-0s7ok4uw	1740	22	or	or	CC
cord-001835-0s7ok4uw	1740	23	in	in	IN
cord-001835-0s7ok4uw	1740	24	the	the	DT
cord-001835-0s7ok4uw	1740	25	case	case	NN
cord-001835-0s7ok4uw	1740	26	of	of	IN
cord-001835-0s7ok4uw	1740	27	S1443D	S1443D	NNP
cord-001835-0s7ok4uw	1740	28	or	or	CC
cord-001835-0s7ok4uw	1740	29	S1441E/	S1441E/	NNPS
cord-001835-0s7ok4uw	1741	1	S1443D	s1443d	NN
cord-001835-0s7ok4uw	1742	1	no	no	DT
cord-001835-0s7ok4uw	1742	2	change	change	NN
cord-001835-0s7ok4uw	1742	3	was	be	VBD
cord-001835-0s7ok4uw	1742	4	observed	observe	VBN
cord-001835-0s7ok4uw	1742	5	,	,	,
cord-001835-0s7ok4uw	1742	6	suggesting	suggest	VBG
cord-001835-0s7ok4uw	1742	7	that	that	IN
cord-001835-0s7ok4uw	1742	8	GBD	GBD	NNP
cord-001835-0s7ok4uw	1742	9	and	and	CC
cord-001835-0s7ok4uw	1742	10	specifically	specifically	RB
cord-001835-0s7ok4uw	1742	11	,	,	,
cord-001835-0s7ok4uw	1742	12	cysteine	cysteine	NN
cord-001835-0s7ok4uw	1742	13	1443	1443	CD
cord-001835-0s7ok4uw	1742	14	is	be	VBZ
cord-001835-0s7ok4uw	1742	15	critical	critical	JJ
cord-001835-0s7ok4uw	1742	16	for	for	IN
cord-001835-0s7ok4uw	1742	17	this	this	DT
cord-001835-0s7ok4uw	1742	18	interaction	interaction	NN
cord-001835-0s7ok4uw	1742	19	.	.	.
cord-001835-0s7ok4uw	1743	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1743	2	,	,	,
cord-001835-0s7ok4uw	1743	3	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1743	4	polarization	polarization	NN
cord-001835-0s7ok4uw	1743	5	results	result	NNS
cord-001835-0s7ok4uw	1743	6	showed	show	VBD
cord-001835-0s7ok4uw	1743	7	that	that	IN
cord-001835-0s7ok4uw	1743	8	the	the	DT
cord-001835-0s7ok4uw	1743	9	GRD	GRD	NNP
cord-001835-0s7ok4uw	1743	10	-	-	HYPH
cord-001835-0s7ok4uw	1743	11	C	C	NNP
cord-001835-0s7ok4uw	1743	12	interact	interact	VBP
cord-001835-0s7ok4uw	1743	13	with	with	IN
cord-001835-0s7ok4uw	1743	14	Cdc42	Cdc42	NNP
cord-001835-0s7ok4uw	1743	15	and	and	CC
cord-001835-0s7ok4uw	1743	16	Rac1	Rac1	NNP
cord-001835-0s7ok4uw	1743	17	but	but	CC
cord-001835-0s7ok4uw	1743	18	not	not	RB
cord-001835-0s7ok4uw	1743	19	with	with	IN
cord-001835-0s7ok4uw	1743	20	RhoA	RhoA	NNP
cord-001835-0s7ok4uw	1743	21	,	,	,
cord-001835-0s7ok4uw	1743	22	and	and	CC
cord-001835-0s7ok4uw	1743	23	interestingly	interestingly	RB
cord-001835-0s7ok4uw	1743	24	the	the	DT
cord-001835-0s7ok4uw	1743	25	GRD	GRD	NNP
cord-001835-0s7ok4uw	1743	26	domain	domain	NN
cord-001835-0s7ok4uw	1743	27	showed	show	VBD
cord-001835-0s7ok4uw	1743	28	similar	similar	JJ
cord-001835-0s7ok4uw	1743	29	behavior	behavior	NN
cord-001835-0s7ok4uw	1743	30	,	,	,
cord-001835-0s7ok4uw	1743	31	but	but	CC
cord-001835-0s7ok4uw	1743	32	with	with	IN
cord-001835-0s7ok4uw	1743	33	10	10	CD
cord-001835-0s7ok4uw	1743	34	to	to	TO
cord-001835-0s7ok4uw	1743	35	15	15	CD
cord-001835-0s7ok4uw	1743	36	folds	fold	NNS
cord-001835-0s7ok4uw	1743	37	lower	low	JJR
cord-001835-0s7ok4uw	1743	38	affinity	affinity	NN
cord-001835-0s7ok4uw	1743	39	as	as	IN
cord-001835-0s7ok4uw	1743	40	compared	compare	VBN
cord-001835-0s7ok4uw	1743	41	with	with	IN
cord-001835-0s7ok4uw	1743	42	the	the	DT
cord-001835-0s7ok4uw	1743	43	GRD	GRD	NNP
cord-001835-0s7ok4uw	1743	44	-	-	HYPH
cord-001835-0s7ok4uw	1743	45	C.	C.	NNP
cord-001835-0s7ok4uw	1743	46	Consistent	Consistent	NNP
cord-001835-0s7ok4uw	1743	47	with	with	IN
cord-001835-0s7ok4uw	1743	48	this	this	DT
cord-001835-0s7ok4uw	1743	49	,	,	,
cord-001835-0s7ok4uw	1743	50	a	a	DT
cord-001835-0s7ok4uw	1743	51	GDP	gdp	NN
cord-001835-0s7ok4uw	1743	52	-	-	HYPH
cord-001835-0s7ok4uw	1743	53	bound	bind	VBN
cord-001835-0s7ok4uw	1743	54	form	form	NN
cord-001835-0s7ok4uw	1743	55	of	of	IN
cord-001835-0s7ok4uw	1743	56	Cdc42	Cdc42	NNP
cord-001835-0s7ok4uw	1743	57	showed	show	VBD
cord-001835-0s7ok4uw	1743	58	interaction	interaction	NN
cord-001835-0s7ok4uw	1743	59	with	with	IN
cord-001835-0s7ok4uw	1743	60	both	both	CC
cord-001835-0s7ok4uw	1743	61	GRD	GRD	NNP
cord-001835-0s7ok4uw	1743	62	and	and	CC
cord-001835-0s7ok4uw	1743	63	the	the	DT
cord-001835-0s7ok4uw	1743	64	GRD	GRD	NNP
cord-001835-0s7ok4uw	1743	65	-	-	HYPH
cord-001835-0s7ok4uw	1743	66	C	C	NNP
cord-001835-0s7ok4uw	1743	67	in	in	IN
cord-001835-0s7ok4uw	1743	68	quiet	quiet	JJ
cord-001835-0s7ok4uw	1743	69	comparable	comparable	JJ
cord-001835-0s7ok4uw	1743	70	affinities	affinity	NNS
cord-001835-0s7ok4uw	1743	71	.	.	.
cord-001835-0s7ok4uw	1744	1	At	at	IN
cord-001835-0s7ok4uw	1744	2	last	last	JJ
cord-001835-0s7ok4uw	1744	3	,	,	,
cord-001835-0s7ok4uw	1744	4	competition	competition	NN
cord-001835-0s7ok4uw	1744	5	experiments	experiment	NNS
cord-001835-0s7ok4uw	1744	6	utilizing	utilize	VBG
cord-001835-0s7ok4uw	1744	7	interacting	interact	VBG
cord-001835-0s7ok4uw	1744	8	partners	partner	NNS
cord-001835-0s7ok4uw	1744	9	of	of	IN
cord-001835-0s7ok4uw	1744	10	Rac1	Rac1	NNP
cord-001835-0s7ok4uw	1744	11	,	,	,
cord-001835-0s7ok4uw	1744	12	e.g.	e.g.	RB
cord-001835-0s7ok4uw	1744	13	Tiam1	Tiam1	NNP
cord-001835-0s7ok4uw	1744	14	,	,	,
cord-001835-0s7ok4uw	1744	15	p50RhoGAP	p50rhogap	NN
cord-001835-0s7ok4uw	1744	16	,	,	,
cord-001835-0s7ok4uw	1744	17	Plexin	Plexin	NNP
cord-001835-0s7ok4uw	1744	18	-	-	HYPH
cord-001835-0s7ok4uw	1744	19	B1	b1	NN
cord-001835-0s7ok4uw	1744	20	,	,	,
cord-001835-0s7ok4uw	1744	21	p67phox	p67phox	NN
cord-001835-0s7ok4uw	1744	22	,	,	,
cord-001835-0s7ok4uw	1744	23	PAK1	PAK1	NNP
cord-001835-0s7ok4uw	1744	24	and	and	CC
cord-001835-0s7ok4uw	1744	25	RhoGDIa	RhoGDIa	VBD
cord-001835-0s7ok4uw	1744	26	,	,	,
cord-001835-0s7ok4uw	1744	27	along	along	IN
cord-001835-0s7ok4uw	1744	28	with	with	IN
cord-001835-0s7ok4uw	1744	29	structural	structural	JJ
cord-001835-0s7ok4uw	1744	30	analysis	analysis	NN
cord-001835-0s7ok4uw	1744	31	,	,	,
cord-001835-0s7ok4uw	1744	32	revealed	reveal	VBD
cord-001835-0s7ok4uw	1744	33	two	two	CD
cord-001835-0s7ok4uw	1744	34	negative	negative	JJ
cord-001835-0s7ok4uw	1744	35	charged	charge	VBN
cord-001835-0s7ok4uw	1744	36	areas	area	NNS
cord-001835-0s7ok4uw	1744	37	on	on	IN
cord-001835-0s7ok4uw	1744	38	the	the	DT
cord-001835-0s7ok4uw	1744	39	surface	surface	NN
cord-001835-0s7ok4uw	1744	40	of	of	IN
cord-001835-0s7ok4uw	1744	41	Rho	rho	NN
cord-001835-0s7ok4uw	1744	42	-	-	:
cord-001835-0s7ok4uw	1744	43	and	and	CC
cord-001835-0s7ok4uw	1744	44	Rnd	Rnd	NNP
cord-001835-0s7ok4uw	1744	45	-	-	HYPH
cord-001835-0s7ok4uw	1744	46	like	like	JJ
cord-001835-0s7ok4uw	1744	47	proteins	protein	NNS
cord-001835-0s7ok4uw	1744	48	,	,	,
cord-001835-0s7ok4uw	1744	49	which	which	WDT
cord-001835-0s7ok4uw	1744	50	might	may	MD
cord-001835-0s7ok4uw	1744	51	explain	explain	VB
cord-001835-0s7ok4uw	1744	52	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1744	53	inaccessible	inaccessible	JJ
cord-001835-0s7ok4uw	1744	54	interaction	interaction	NN
cord-001835-0s7ok4uw	1744	55	with	with	IN
cord-001835-0s7ok4uw	1744	56	IQGAP1	iqgap1	NN
cord-001835-0s7ok4uw	1744	57	.	.	.
cord-001835-0s7ok4uw	1745	1	The	the	DT
cord-001835-0s7ok4uw	1745	2	overlapping	overlap	VBG
cord-001835-0s7ok4uw	1745	3	binding	binding	NN
cord-001835-0s7ok4uw	1745	4	site	site	NN
cord-001835-0s7ok4uw	1745	5	of	of	IN
cord-001835-0s7ok4uw	1745	6	Cdc42	Cdc42	NNP
cord-001835-0s7ok4uw	1745	7	and	and	CC
cord-001835-0s7ok4uw	1745	8	Rac1	Rac1	NNP
cord-001835-0s7ok4uw	1745	9	on	on	IN
cord-001835-0s7ok4uw	1745	10	the	the	DT
cord-001835-0s7ok4uw	1745	11	surface	surface	NN
cord-001835-0s7ok4uw	1745	12	of	of	IN
cord-001835-0s7ok4uw	1745	13	IQGAP1	iqgap1	NN
cord-001835-0s7ok4uw	1745	14	together	together	RB
cord-001835-0s7ok4uw	1745	15	with	with	IN
cord-001835-0s7ok4uw	1745	16	the	the	DT
cord-001835-0s7ok4uw	1745	17	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1745	18	details	detail	NNS
cord-001835-0s7ok4uw	1745	19	of	of	IN
cord-001835-0s7ok4uw	1745	20	the	the	DT
cord-001835-0s7ok4uw	1745	21	selective	selective	JJ
cord-001835-0s7ok4uw	1745	22	interaction	interaction	NN
cord-001835-0s7ok4uw	1745	23	of	of	IN
cord-001835-0s7ok4uw	1745	24	IQGAP1	iqgap1	NN
cord-001835-0s7ok4uw	1745	25	with	with	IN
cord-001835-0s7ok4uw	1745	26	Rac	Rac	NNP
cord-001835-0s7ok4uw	1745	27	-	-	,
cord-001835-0s7ok4uw	1745	28	and	and	CC
cord-001835-0s7ok4uw	1745	29	Cdc42-like	cdc42-like	JJ
cord-001835-0s7ok4uw	1745	30	proteins	protein	NNS
cord-001835-0s7ok4uw	1745	31	suggests	suggest	VBZ
cord-001835-0s7ok4uw	1745	32	that	that	IN
cord-001835-0s7ok4uw	1745	33	these	these	DT
cord-001835-0s7ok4uw	1745	34	interactions	interaction	NNS
cord-001835-0s7ok4uw	1745	35	are	be	VBP
cord-001835-0s7ok4uw	1745	36	most	most	RBS
cord-001835-0s7ok4uw	1745	37	likely	likely	RB
cord-001835-0s7ok4uw	1745	38	mediated	mediate	VBN
cord-001835-0s7ok4uw	1745	39	via	via	IN
cord-001835-0s7ok4uw	1745	40	the	the	DT
cord-001835-0s7ok4uw	1745	41	same	same	JJ
cord-001835-0s7ok4uw	1745	42	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1745	43	.	.	.
cord-001835-0s7ok4uw	1746	1	ING4	ING4	NNP
cord-001835-0s7ok4uw	1746	2	dimerizes	dimerize	NNS
cord-001835-0s7ok4uw	1746	3	through	through	IN
cord-001835-0s7ok4uw	1746	4	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1746	5	N	n	CD
cord-001835-0s7ok4uw	1746	6	-	-	HYPH
cord-001835-0s7ok4uw	1746	7	terminal	terminal	NN
cord-001835-0s7ok4uw	1746	8	domain	domain	NN
cord-001835-0s7ok4uw	1746	9	,	,	,
cord-001835-0s7ok4uw	1746	10	with	with	IN
cord-001835-0s7ok4uw	1746	11	a	a	DT
cord-001835-0s7ok4uw	1746	12	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	1746	13	antiparallel	antiparallel	NN
cord-001835-0s7ok4uw	1746	14	coiled	coil	VBN
cord-001835-0s7ok4uw	1746	15	-	-	HYPH
cord-001835-0s7ok4uw	1746	16	coil	coil	NN
cord-001835-0s7ok4uw	1746	17	structure3	structure3	NN
cord-001835-0s7ok4uw	1746	18	,	,	,
cord-001835-0s7ok4uw	1746	19	making	make	VBG
cord-001835-0s7ok4uw	1746	20	it	-PRON-	PRP
cord-001835-0s7ok4uw	1746	21	a	a	DT
cord-001835-0s7ok4uw	1746	22	bivalent	bivalent	JJ
cord-001835-0s7ok4uw	1746	23	reader	reader	NN
cord-001835-0s7ok4uw	1746	24	of	of	IN
cord-001835-0s7ok4uw	1746	25	the	the	DT
cord-001835-0s7ok4uw	1746	26	H3K4me3	h3k4me3	NN
cord-001835-0s7ok4uw	1746	27	mark	mark	NN
cord-001835-0s7ok4uw	1746	28	.	.	.
cord-001835-0s7ok4uw	1747	1	ING5	ING5	NNP
cord-001835-0s7ok4uw	1747	2	is	be	VBZ
cord-001835-0s7ok4uw	1747	3	highly	highly	RB
cord-001835-0s7ok4uw	1747	4	homologous	homologous	JJ
cord-001835-0s7ok4uw	1747	5	with	with	IN
cord-001835-0s7ok4uw	1747	6	ING4	ING4	NNP
cord-001835-0s7ok4uw	1747	7	,	,	,
cord-001835-0s7ok4uw	1747	8	but	but	CC
cord-001835-0s7ok4uw	1747	9	forms	form	VBZ
cord-001835-0s7ok4uw	1747	10	part	part	NN
cord-001835-0s7ok4uw	1747	11	of	of	IN
cord-001835-0s7ok4uw	1747	12	a	a	DT
cord-001835-0s7ok4uw	1747	13	different	different	JJ
cord-001835-0s7ok4uw	1747	14	histone	histone	NN
cord-001835-0s7ok4uw	1747	15	acetyl	acetyl	NN
cord-001835-0s7ok4uw	1747	16	transferase	transferase	NN
cord-001835-0s7ok4uw	1747	17	complex1	complex1	NN
cord-001835-0s7ok4uw	1747	18	.	.	.
cord-001835-0s7ok4uw	1748	1	Here	here	RB
cord-001835-0s7ok4uw	1748	2	,	,	,
cord-001835-0s7ok4uw	1748	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1748	4	show	show	VBP
cord-001835-0s7ok4uw	1748	5	that	that	IN
cord-001835-0s7ok4uw	1748	6	ING5	ING5	NNP
cord-001835-0s7ok4uw	1748	7	is	be	VBZ
cord-001835-0s7ok4uw	1748	8	also	also	RB
cord-001835-0s7ok4uw	1748	9	a	a	DT
cord-001835-0s7ok4uw	1748	10	dimer	dimer	NN
cord-001835-0s7ok4uw	1748	11	and	and	CC
cord-001835-0s7ok4uw	1748	12	thus	thus	RB
cord-001835-0s7ok4uw	1748	13	a	a	DT
cord-001835-0s7ok4uw	1748	14	bivalent	bivalent	JJ
cord-001835-0s7ok4uw	1748	15	reader	reader	NN
cord-001835-0s7ok4uw	1748	16	of	of	IN
cord-001835-0s7ok4uw	1748	17	the	the	DT
cord-001835-0s7ok4uw	1748	18	H3K4me3	h3k4me3	NN
cord-001835-0s7ok4uw	1748	19	mark	mark	NN
cord-001835-0s7ok4uw	1748	20	.	.	.
cord-001835-0s7ok4uw	1749	1	However	however	RB
cord-001835-0s7ok4uw	1749	2	,	,	,
cord-001835-0s7ok4uw	1749	3	the	the	DT
cord-001835-0s7ok4uw	1749	4	crystal	crystal	NN
cord-001835-0s7ok4uw	1749	5	structure	structure	NN
cord-001835-0s7ok4uw	1749	6	of	of	IN
cord-001835-0s7ok4uw	1749	7	the	the	DT
cord-001835-0s7ok4uw	1749	8	N	n	CD
cord-001835-0s7ok4uw	1749	9	-	-	HYPH
cord-001835-0s7ok4uw	1749	10	terminal	terminal	NN
cord-001835-0s7ok4uw	1749	11	domain	domain	NN
cord-001835-0s7ok4uw	1749	12	of	of	IN
cord-001835-0s7ok4uw	1749	13	ING5	ING5	NNP
cord-001835-0s7ok4uw	1749	14	shows	show	VBZ
cord-001835-0s7ok4uw	1749	15	an	an	DT
cord-001835-0s7ok4uw	1749	16	asymmetric	asymmetric	JJ
cord-001835-0s7ok4uw	1749	17	dimer	dimer	NN
cord-001835-0s7ok4uw	1749	18	,	,	,
cord-001835-0s7ok4uw	1749	19	different	different	JJ
cord-001835-0s7ok4uw	1749	20	from	from	IN
cord-001835-0s7ok4uw	1749	21	the	the	DT
cord-001835-0s7ok4uw	1749	22	homologous	homologous	JJ
cord-001835-0s7ok4uw	1749	23	ING4	ING4	NNP
cord-001835-0s7ok4uw	1749	24	domain	domain	NN
cord-001835-0s7ok4uw	1749	25	.	.	.
cord-001835-0s7ok4uw	1750	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	1750	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	1750	3	data	datum	NNS
cord-001835-0s7ok4uw	1750	4	(	(	-LRB-
cord-001835-0s7ok4uw	1750	5	backbone	backbone	NN
cord-001835-0s7ok4uw	1750	6	assignment	assignment	NN
cord-001835-0s7ok4uw	1750	7	and	and	CC
cord-001835-0s7ok4uw	1750	8	paramagnetic	paramagnetic	JJ
cord-001835-0s7ok4uw	1750	9	relaxation	relaxation	NN
cord-001835-0s7ok4uw	1750	10	effects	effect	NNS
cord-001835-0s7ok4uw	1750	11	)	)	-RRB-
cord-001835-0s7ok4uw	1750	12	and	and	CC
cord-001835-0s7ok4uw	1750	13	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	1750	14	data	datum	NNS
cord-001835-0s7ok4uw	1750	15	indicate	indicate	VBP
cord-001835-0s7ok4uw	1750	16	that	that	IN
cord-001835-0s7ok4uw	1750	17	the	the	DT
cord-001835-0s7ok4uw	1750	18	structure	structure	NN
cord-001835-0s7ok4uw	1750	19	of	of	IN
cord-001835-0s7ok4uw	1750	20	the	the	DT
cord-001835-0s7ok4uw	1750	21	N	n	CD
cord-001835-0s7ok4uw	1750	22	-	-	HYPH
cord-001835-0s7ok4uw	1750	23	terminal	terminal	NN
cord-001835-0s7ok4uw	1750	24	domain	domain	NN
cord-001835-0s7ok4uw	1750	25	of	of	IN
cord-001835-0s7ok4uw	1750	26	ING5	ING5	NNP
cord-001835-0s7ok4uw	1750	27	in	in	IN
cord-001835-0s7ok4uw	1750	28	solution	solution	NN
cord-001835-0s7ok4uw	1750	29	is	be	VBZ
cord-001835-0s7ok4uw	1750	30	similar	similar	JJ
cord-001835-0s7ok4uw	1750	31	to	to	IN
cord-001835-0s7ok4uw	1750	32	ING4	ING4	NNP
cord-001835-0s7ok4uw	1750	33	,	,	,
cord-001835-0s7ok4uw	1750	34	suggesting	suggest	VBG
cord-001835-0s7ok4uw	1750	35	that	that	IN
cord-001835-0s7ok4uw	1750	36	the	the	DT
cord-001835-0s7ok4uw	1750	37	crystal	crystal	NN
cord-001835-0s7ok4uw	1750	38	structure	structure	NN
cord-001835-0s7ok4uw	1750	39	of	of	IN
cord-001835-0s7ok4uw	1750	40	ING5	ING5	NNP
cord-001835-0s7ok4uw	1750	41	is	be	VBZ
cord-001835-0s7ok4uw	1750	42	likely	likely	RB
cord-001835-0s7ok4uw	1750	43	a	a	DT
cord-001835-0s7ok4uw	1750	44	crystallization	crystallization	NN
cord-001835-0s7ok4uw	1750	45	artifact	artifact	NN
cord-001835-0s7ok4uw	1750	46	.	.	.
cord-001835-0s7ok4uw	1751	1	Three	three	CD
cord-001835-0s7ok4uw	1751	2	point	point	NN
cord-001835-0s7ok4uw	1751	3	mutations	mutation	NNS
cord-001835-0s7ok4uw	1751	4	in	in	IN
cord-001835-0s7ok4uw	1751	5	the	the	DT
cord-001835-0s7ok4uw	1751	6	N	n	CD
cord-001835-0s7ok4uw	1751	7	-	-	HYPH
cord-001835-0s7ok4uw	1751	8	terminal	terminal	NN
cord-001835-0s7ok4uw	1751	9	domain	domain	NN
cord-001835-0s7ok4uw	1751	10	of	of	IN
cord-001835-0s7ok4uw	1751	11	ING5	ING5	NNP
cord-001835-0s7ok4uw	1751	12	have	have	VBP
cord-001835-0s7ok4uw	1751	13	been	be	VBN
cord-001835-0s7ok4uw	1751	14	described	describe	VBN
cord-001835-0s7ok4uw	1751	15	in	in	IN
cord-001835-0s7ok4uw	1751	16	oral	oral	JJ
cord-001835-0s7ok4uw	1751	17	squamous	squamous	JJ
cord-001835-0s7ok4uw	1751	18	cell	cell	NN
cord-001835-0s7ok4uw	1751	19	carcinoma	carcinoma	NN
cord-001835-0s7ok4uw	1751	20	:	:	:
cord-001835-0s7ok4uw	1751	21	Q33R	Q33R	NNP
cord-001835-0s7ok4uw	1751	22	,	,	,
cord-001835-0s7ok4uw	1751	23	I68V	I68V	NNPS
cord-001835-0s7ok4uw	1751	24	,	,	,
cord-001835-0s7ok4uw	1751	25	and	and	CC
cord-001835-0s7ok4uw	1751	26	C75R4	C75R4	NNP
cord-001835-0s7ok4uw	1751	27	.	.	.
cord-001835-0s7ok4uw	1752	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1752	2	have	have	VBP
cord-001835-0s7ok4uw	1752	3	found	find	VBN
cord-001835-0s7ok4uw	1752	4	that	that	IN
cord-001835-0s7ok4uw	1752	5	the	the	DT
cord-001835-0s7ok4uw	1752	6	N	n	CD
cord-001835-0s7ok4uw	1752	7	-	-	HYPH
cord-001835-0s7ok4uw	1752	8	terminal	terminal	NN
cord-001835-0s7ok4uw	1752	9	domains	domain	NNS
cord-001835-0s7ok4uw	1752	10	of	of	IN
cord-001835-0s7ok4uw	1752	11	the	the	DT
cord-001835-0s7ok4uw	1752	12	three	three	CD
cord-001835-0s7ok4uw	1752	13	mutants	mutant	NNS
cord-001835-0s7ok4uw	1752	14	are	be	VBP
cord-001835-0s7ok4uw	1752	15	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	1752	16	coiled	coil	VBN
cord-001835-0s7ok4uw	1752	17	-	-	HYPH
cord-001835-0s7ok4uw	1752	18	coils	coil	NNS
cord-001835-0s7ok4uw	1752	19	but	but	CC
cord-001835-0s7ok4uw	1752	20	with	with	IN
cord-001835-0s7ok4uw	1752	21	different	different	JJ
cord-001835-0s7ok4uw	1752	22	stability	stability	NN
cord-001835-0s7ok4uw	1752	23	,	,	,
cord-001835-0s7ok4uw	1752	24	as	as	IN
cord-001835-0s7ok4uw	1752	25	measured	measure	VBN
cord-001835-0s7ok4uw	1752	26	by	by	IN
cord-001835-0s7ok4uw	1752	27	thermal	thermal	JJ
cord-001835-0s7ok4uw	1752	28	denaturation	denaturation	NN
cord-001835-0s7ok4uw	1752	29	.	.	.
cord-001835-0s7ok4uw	1753	1	While	while	IN
cord-001835-0s7ok4uw	1753	2	the	the	DT
cord-001835-0s7ok4uw	1753	3	Q33R	Q33R	NNP
cord-001835-0s7ok4uw	1753	4	mutant	mutant	JJ
cord-001835-0s7ok4uw	1753	5	is	be	VBZ
cord-001835-0s7ok4uw	1753	6	as	as	RB
cord-001835-0s7ok4uw	1753	7	stable	stable	JJ
cord-001835-0s7ok4uw	1753	8	as	as	IN
cord-001835-0s7ok4uw	1753	9	the	the	DT
cord-001835-0s7ok4uw	1753	10	wild	wild	JJ
cord-001835-0s7ok4uw	1753	11	type	type	NN
cord-001835-0s7ok4uw	1753	12	,	,	,
cord-001835-0s7ok4uw	1753	13	the	the	DT
cord-001835-0s7ok4uw	1753	14	I68V	I68V	NNS
cord-001835-0s7ok4uw	1753	15	and	and	CC
cord-001835-0s7ok4uw	1753	16	C75R	C75R	NNP
cord-001835-0s7ok4uw	1753	17	mutants	mutant	NNS
cord-001835-0s7ok4uw	1753	18	are	be	VBP
cord-001835-0s7ok4uw	1753	19	strongly	strongly	RB
cord-001835-0s7ok4uw	1753	20	destabilized	destabilize	VBN
cord-001835-0s7ok4uw	1753	21	,	,	,
cord-001835-0s7ok4uw	1753	22	suggesting	suggest	VBG
cord-001835-0s7ok4uw	1753	23	a	a	DT
cord-001835-0s7ok4uw	1753	24	role	role	NN
cord-001835-0s7ok4uw	1753	25	in	in	IN
cord-001835-0s7ok4uw	1753	26	cancer	cancer	NN
cord-001835-0s7ok4uw	1753	27	development	development	NN
cord-001835-0s7ok4uw	1753	28	at	at	IN
cord-001835-0s7ok4uw	1753	29	least	least	JJS
cord-001835-0s7ok4uw	1753	30	for	for	IN
cord-001835-0s7ok4uw	1753	31	these	these	DT
cord-001835-0s7ok4uw	1753	32	two	two	CD
cord-001835-0s7ok4uw	1753	33	mutants	mutant	NNS
cord-001835-0s7ok4uw	1753	34	.	.	.
cord-001835-0s7ok4uw	1753	35	 	 	_SP
cord-001835-0s7ok4uw	1754	1	Efforts	effort	NNS
cord-001835-0s7ok4uw	1754	2	so	so	RB
cord-001835-0s7ok4uw	1754	3	far	far	RB
cord-001835-0s7ok4uw	1754	4	,	,	,
cord-001835-0s7ok4uw	1754	5	to	to	TO
cord-001835-0s7ok4uw	1754	6	combat	combat	VB
cord-001835-0s7ok4uw	1754	7	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	1754	8	's	's	POS
cord-001835-0s7ok4uw	1754	9	disease	disease	NN
cord-001835-0s7ok4uw	1754	10	(	(	-LRB-
cord-001835-0s7ok4uw	1754	11	AD	ad	NN
cord-001835-0s7ok4uw	1754	12	)	)	-RRB-
cord-001835-0s7ok4uw	1754	13	have	have	VBP
cord-001835-0s7ok4uw	1754	14	focused	focus	VBN
cord-001835-0s7ok4uw	1754	15	predominantly	predominantly	RB
cord-001835-0s7ok4uw	1754	16	on	on	IN
cord-001835-0s7ok4uw	1754	17	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	1754	18	the	the	DT
cord-001835-0s7ok4uw	1754	19	activity	activity	NN
cord-001835-0s7ok4uw	1754	20	of	of	IN
cord-001835-0s7ok4uw	1754	21	enzyme(s	enzyme(s	NNP
cord-001835-0s7ok4uw	1754	22	)	)	-RRB-
cord-001835-0s7ok4uw	1754	23	that	that	WDT
cord-001835-0s7ok4uw	1754	24	are	be	VBP
cord-001835-0s7ok4uw	1754	25	responsible	responsible	JJ
cord-001835-0s7ok4uw	1754	26	for	for	IN
cord-001835-0s7ok4uw	1754	27	the	the	DT
cord-001835-0s7ok4uw	1754	28	production	production	NN
cord-001835-0s7ok4uw	1754	29	of	of	IN
cord-001835-0s7ok4uw	1754	30	the	the	DT
cord-001835-0s7ok4uw	1754	31	main	main	JJ
cord-001835-0s7ok4uw	1754	32	causative	causative	JJ
cord-001835-0s7ok4uw	1754	33	beta	beta	NN
cord-001835-0s7ok4uw	1754	34	amyloid	amyloid	NN
cord-001835-0s7ok4uw	1754	35	forming	form	VBG
cord-001835-0s7ok4uw	1754	36	peptide	peptide	JJ
cord-001835-0s7ok4uw	1754	37	.	.	.
cord-001835-0s7ok4uw	1755	1	However	however	RB
cord-001835-0s7ok4uw	1755	2	,	,	,
cord-001835-0s7ok4uw	1755	3	the	the	DT
cord-001835-0s7ok4uw	1755	4	inherent	inherent	JJ
cord-001835-0s7ok4uw	1755	5	complexity	complexity	NN
cord-001835-0s7ok4uw	1755	6	associated	associate	VBN
cord-001835-0s7ok4uw	1755	7	with	with	IN
cord-001835-0s7ok4uw	1755	8	the	the	DT
cord-001835-0s7ok4uw	1755	9	network	network	NN
cord-001835-0s7ok4uw	1755	10	of	of	IN
cord-001835-0s7ok4uw	1755	11	pathways	pathway	NNS
cord-001835-0s7ok4uw	1755	12	leading	lead	VBG
cord-001835-0s7ok4uw	1755	13	to	to	IN
cord-001835-0s7ok4uw	1755	14	the	the	DT
cord-001835-0s7ok4uw	1755	15	progress	progress	NN
cord-001835-0s7ok4uw	1755	16	of	of	IN
cord-001835-0s7ok4uw	1755	17	the	the	DT
cord-001835-0s7ok4uw	1755	18	disease	disease	NN
cord-001835-0s7ok4uw	1755	19	may	may	MD
cord-001835-0s7ok4uw	1755	20	involve	involve	VB
cord-001835-0s7ok4uw	1755	21	additional	additional	JJ
cord-001835-0s7ok4uw	1755	22	targets	target	NNS
cord-001835-0s7ok4uw	1755	23	for	for	IN
cord-001835-0s7ok4uw	1755	24	designing	design	VBG
cord-001835-0s7ok4uw	1755	25	effective	effective	JJ
cord-001835-0s7ok4uw	1755	26	therapies	therapy	NNS
cord-001835-0s7ok4uw	1755	27	.	.	.
cord-001835-0s7ok4uw	1756	1	Recent	recent	JJ
cord-001835-0s7ok4uw	1756	2	experimental	experimental	JJ
cord-001835-0s7ok4uw	1756	3	findings	finding	NNS
cord-001835-0s7ok4uw	1756	4	have	have	VBP
cord-001835-0s7ok4uw	1756	5	identified	identify	VBN
cord-001835-0s7ok4uw	1756	6	Abelson	Abelson	NNP
cord-001835-0s7ok4uw	1756	7	's	's	POS
cord-001835-0s7ok4uw	1756	8	Tyrosine	Tyrosine	NNP
cord-001835-0s7ok4uw	1756	9	Kinase	Kinase	NNP
cord-001835-0s7ok4uw	1756	10	(	(	-LRB-
cord-001835-0s7ok4uw	1756	11	c	c	NN
cord-001835-0s7ok4uw	1756	12	-	-	:
cord-001835-0s7ok4uw	1756	13	Abl	Abl	NNP
cord-001835-0s7ok4uw	1756	14	)	)	-RRB-
cord-001835-0s7ok4uw	1756	15	,	,	,
cord-001835-0s7ok4uw	1756	16	a	a	DT
cord-001835-0s7ok4uw	1756	17	non	non	JJ
cord-001835-0s7ok4uw	1756	18	-	-	JJ
cord-001835-0s7ok4uw	1756	19	receptor	receptor	JJ
cord-001835-0s7ok4uw	1756	20	kinase	kinase	NNS
cord-001835-0s7ok4uw	1756	21	involved	involve	VBN
cord-001835-0s7ok4uw	1756	22	in	in	IN
cord-001835-0s7ok4uw	1756	23	a	a	DT
cord-001835-0s7ok4uw	1756	24	variety	variety	NN
cord-001835-0s7ok4uw	1756	25	of	of	IN
cord-001835-0s7ok4uw	1756	26	cellular	cellular	JJ
cord-001835-0s7ok4uw	1756	27	functions	function	NNS
cord-001835-0s7ok4uw	1756	28	as	as	IN
cord-001835-0s7ok4uw	1756	29	a	a	DT
cord-001835-0s7ok4uw	1756	30	new	new	JJ
cord-001835-0s7ok4uw	1756	31	target	target	NN
cord-001835-0s7ok4uw	1756	32	for	for	IN
cord-001835-0s7ok4uw	1756	33	AD	ad	NN
cord-001835-0s7ok4uw	1756	34	.	.	.
cord-001835-0s7ok4uw	1757	1	In	in	IN
cord-001835-0s7ok4uw	1757	2	the	the	DT
cord-001835-0s7ok4uw	1757	3	present	present	JJ
cord-001835-0s7ok4uw	1757	4	study	study	NN
cord-001835-0s7ok4uw	1757	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1757	6	employed	employ	VBD
cord-001835-0s7ok4uw	1757	7	energy	energy	NN
cord-001835-0s7ok4uw	1757	8	optimized	optimize	VBD
cord-001835-0s7ok4uw	1757	9	multiple	multiple	JJ
cord-001835-0s7ok4uw	1757	10	pharmacophore	pharmacophore	NN
cord-001835-0s7ok4uw	1757	11	modeling	modeling	NN
cord-001835-0s7ok4uw	1757	12	strategy	strategy	NN
cord-001835-0s7ok4uw	1757	13	from	from	IN
cord-001835-0s7ok4uw	1757	14	multiple	multiple	JJ
cord-001835-0s7ok4uw	1757	15	c	c	NN
cord-001835-0s7ok4uw	1757	16	-	-	:
cord-001835-0s7ok4uw	1757	17	Abl	abl	JJ
cord-001835-0s7ok4uw	1757	18	structures	structure	NNS
cord-001835-0s7ok4uw	1757	19	bound	bind	VBN
cord-001835-0s7ok4uw	1757	20	with	with	IN
cord-001835-0s7ok4uw	1757	21	ligands	ligand	NNS
cord-001835-0s7ok4uw	1757	22	in	in	IN
cord-001835-0s7ok4uw	1757	23	the	the	DT
cord-001835-0s7ok4uw	1757	24	inactive	inactive	JJ
cord-001835-0s7ok4uw	1757	25	ATP	ATP	NNP
cord-001835-0s7ok4uw	1757	26	binding	bind	VBG
cord-001835-0s7ok4uw	1757	27	conformation	conformation	NN
cord-001835-0s7ok4uw	1757	28	.	.	.
cord-001835-0s7ok4uw	1758	1	Virtual	virtual	JJ
cord-001835-0s7ok4uw	1758	2	screening	screening	NN
cord-001835-0s7ok4uw	1758	3	followed	follow	VBN
cord-001835-0s7ok4uw	1758	4	by	by	IN
cord-001835-0s7ok4uw	1758	5	docking	docking	NN
cord-001835-0s7ok4uw	1758	6	of	of	IN
cord-001835-0s7ok4uw	1758	7	molecules	molecule	NNS
cord-001835-0s7ok4uw	1758	8	from	from	IN
cord-001835-0s7ok4uw	1758	9	ChemBridge_CNS	ChemBridge_CNS	NNP
cord-001835-0s7ok4uw	1758	10	database	database	NN
cord-001835-0s7ok4uw	1758	11	,	,	,
cord-001835-0s7ok4uw	1758	12	and	and	CC
cord-001835-0s7ok4uw	1758	13	Maybridge	Maybridge	NNP
cord-001835-0s7ok4uw	1758	14	databases	database	NNS
cord-001835-0s7ok4uw	1758	15	resulted	result	VBD
cord-001835-0s7ok4uw	1758	16	in	in	IN
cord-001835-0s7ok4uw	1758	17	the	the	DT
cord-001835-0s7ok4uw	1758	18	identification	identification	NN
cord-001835-0s7ok4uw	1758	19	of	of	IN
cord-001835-0s7ok4uw	1758	20	15	15	CD
cord-001835-0s7ok4uw	1758	21	best	well	RBS
cord-001835-0s7ok4uw	1758	22	scoring	scoring	NN
cord-001835-0s7ok4uw	1758	23	molecules	molecule	NNS
cord-001835-0s7ok4uw	1758	24	.	.	.
cord-001835-0s7ok4uw	1759	1	Based	base	VBN
cord-001835-0s7ok4uw	1759	2	on	on	IN
cord-001835-0s7ok4uw	1759	3	docking	docking	NN
cord-001835-0s7ok4uw	1759	4	score	score	NN
cord-001835-0s7ok4uw	1759	5	and	and	CC
cord-001835-0s7ok4uw	1759	6	selectivity	selectivity	NN
cord-001835-0s7ok4uw	1759	7	assessment	assessment	NN
cord-001835-0s7ok4uw	1759	8	and	and	CC
cord-001835-0s7ok4uw	1759	9	druggability	druggability	NN
cord-001835-0s7ok4uw	1759	10	parameters	parameter	NNS
cord-001835-0s7ok4uw	1759	11	,	,	,
cord-001835-0s7ok4uw	1759	12	four	four	CD
cord-001835-0s7ok4uw	1759	13	out	out	IN
cord-001835-0s7ok4uw	1759	14	of	of	IN
cord-001835-0s7ok4uw	1759	15	the	the	DT
cord-001835-0s7ok4uw	1759	16	15	15	CD
cord-001835-0s7ok4uw	1759	17	molecules	molecule	NNS
cord-001835-0s7ok4uw	1759	18	are	be	VBP
cord-001835-0s7ok4uw	1759	19	predicted	predict	VBN
cord-001835-0s7ok4uw	1759	20	to	to	TO
cord-001835-0s7ok4uw	1759	21	show	show	VB
cord-001835-0s7ok4uw	1759	22	increased	increase	VBN
cord-001835-0s7ok4uw	1759	23	specificity	specificity	NN
cord-001835-0s7ok4uw	1759	24	for	for	IN
cord-001835-0s7ok4uw	1759	25	c	c	NN
cord-001835-0s7ok4uw	1759	26	-	-	:
cord-001835-0s7ok4uw	1759	27	Abl	Abl	NNP
cord-001835-0s7ok4uw	1759	28	in	in	IN
cord-001835-0s7ok4uw	1759	29	comparison	comparison	NN
cord-001835-0s7ok4uw	1759	30	to	to	IN
cord-001835-0s7ok4uw	1759	31	closely	closely	RB
cord-001835-0s7ok4uw	1759	32	related	relate	VBN
cord-001835-0s7ok4uw	1759	33	kinases	kinase	NNS
cord-001835-0s7ok4uw	1759	34	.	.	.
cord-001835-0s7ok4uw	1760	1	Given	give	VBN
cord-001835-0s7ok4uw	1760	2	the	the	DT
cord-001835-0s7ok4uw	1760	3	implied	implied	JJ
cord-001835-0s7ok4uw	1760	4	role	role	NN
cord-001835-0s7ok4uw	1760	5	of	of	IN
cord-001835-0s7ok4uw	1760	6	c	c	NN
cord-001835-0s7ok4uw	1760	7	-	-	:
cord-001835-0s7ok4uw	1760	8	Abl	Abl	NNP
cord-001835-0s7ok4uw	1760	9	not	not	RB
cord-001835-0s7ok4uw	1760	10	only	only	RB
cord-001835-0s7ok4uw	1760	11	in	in	IN
cord-001835-0s7ok4uw	1760	12	AD	ad	NN
cord-001835-0s7ok4uw	1760	13	but	but	CC
cord-001835-0s7ok4uw	1760	14	in	in	IN
cord-001835-0s7ok4uw	1760	15	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	1760	16	's	's	POS
cord-001835-0s7ok4uw	1760	17	disease	disease	NN
cord-001835-0s7ok4uw	1760	18	,	,	,
cord-001835-0s7ok4uw	1760	19	the	the	DT
cord-001835-0s7ok4uw	1760	20	identified	identify	VBN
cord-001835-0s7ok4uw	1760	21	compounds	compound	NNS
cord-001835-0s7ok4uw	1760	22	may	may	MD
cord-001835-0s7ok4uw	1760	23	serve	serve	VB
cord-001835-0s7ok4uw	1760	24	as	as	IN
cord-001835-0s7ok4uw	1760	25	leads	lead	NNS
cord-001835-0s7ok4uw	1760	26	to	to	TO
cord-001835-0s7ok4uw	1760	27	be	be	VB
cord-001835-0s7ok4uw	1760	28	developed	develop	VBN
cord-001835-0s7ok4uw	1760	29	as	as	IN
cord-001835-0s7ok4uw	1760	30	effective	effective	JJ
cord-001835-0s7ok4uw	1760	31	neurotherapeutics	neurotherapeutic	NNS
cord-001835-0s7ok4uw	1760	32	.	.	.
cord-001835-0s7ok4uw	1761	1	Rafael	Rafael	NNP
cord-001835-0s7ok4uw	1761	2	Palomino	Palomino	NNP
cord-001835-0s7ok4uw	1761	3	1	1	CD
cord-001835-0s7ok4uw	1761	4	,	,	,
cord-001835-0s7ok4uw	1761	5	Glenn	Glenn	NNP
cord-001835-0s7ok4uw	1761	6	Millhauser	Millhauser	NNP
cord-001835-0s7ok4uw	1761	7	2	2	CD
cord-001835-0s7ok4uw	1761	8	,	,	,
cord-001835-0s7ok4uw	1761	9	Pietro	Pietro	NNP
cord-001835-0s7ok4uw	1761	10	Sanna	Sanna	NNP
cord-001835-0s7ok4uw	1761	11	2	2	CD
cord-001835-0s7ok4uw	1761	12	1	1	CD
cord-001835-0s7ok4uw	1761	13	University	University	NNP
cord-001835-0s7ok4uw	1761	14	of	of	IN
cord-001835-0s7ok4uw	1761	15	California	California	NNP
cord-001835-0s7ok4uw	1761	16	Santa	Santa	NNP
cord-001835-0s7ok4uw	1761	17	Cruz	Cruz	NNP
cord-001835-0s7ok4uw	1761	18	,	,	,
cord-001835-0s7ok4uw	1761	19	2	2	CD
cord-001835-0s7ok4uw	1762	1	The	the	DT
cord-001835-0s7ok4uw	1762	2	Scripps	Scripps	NNP
cord-001835-0s7ok4uw	1762	3	Research	Research	NNP
cord-001835-0s7ok4uw	1762	4	Institute	Institute	NNP
cord-001835-0s7ok4uw	1763	1	The	the	DT
cord-001835-0s7ok4uw	1763	2	central	central	JJ
cord-001835-0s7ok4uw	1763	3	melanocortin	melanocortin	NNP
cord-001835-0s7ok4uw	1763	4	system	system	NN
cord-001835-0s7ok4uw	1763	5	is	be	VBZ
cord-001835-0s7ok4uw	1763	6	recognized	recognize	VBN
cord-001835-0s7ok4uw	1763	7	as	as	IN
cord-001835-0s7ok4uw	1763	8	a	a	DT
cord-001835-0s7ok4uw	1763	9	key	key	JJ
cord-001835-0s7ok4uw	1763	10	regulator	regulator	NN
cord-001835-0s7ok4uw	1763	11	of	of	IN
cord-001835-0s7ok4uw	1763	12	energy	energy	NN
cord-001835-0s7ok4uw	1763	13	balance	balance	NN
cord-001835-0s7ok4uw	1763	14	and	and	CC
cord-001835-0s7ok4uw	1763	15	appetite	appetite	NN
cord-001835-0s7ok4uw	1763	16	.	.	.
cord-001835-0s7ok4uw	1764	1	The	the	DT
cord-001835-0s7ok4uw	1764	2	hypothalamic	hypothalamic	JJ
cord-001835-0s7ok4uw	1764	3	melanocortin	melanocortin	NNP
cord-001835-0s7ok4uw	1764	4	receptor	receptor	NN
cord-001835-0s7ok4uw	1764	5	,	,	,
cord-001835-0s7ok4uw	1764	6	MC4R	MC4R	NNP
cord-001835-0s7ok4uw	1764	7	,	,	,
cord-001835-0s7ok4uw	1764	8	is	be	VBZ
cord-001835-0s7ok4uw	1764	9	a	a	DT
cord-001835-0s7ok4uw	1764	10	G	g	NN
cord-001835-0s7ok4uw	1764	11	-	-	HYPH
cord-001835-0s7ok4uw	1764	12	protein	protein	NN
cord-001835-0s7ok4uw	1764	13	coupled	couple	VBN
cord-001835-0s7ok4uw	1764	14	receptor	receptor	NN
cord-001835-0s7ok4uw	1764	15	that	that	WDT
cord-001835-0s7ok4uw	1764	16	is	be	VBZ
cord-001835-0s7ok4uw	1764	17	antagonized	antagonize	VBN
cord-001835-0s7ok4uw	1764	18	by	by	IN
cord-001835-0s7ok4uw	1764	19	the	the	DT
cord-001835-0s7ok4uw	1764	20	peptide	peptide	NN
cord-001835-0s7ok4uw	1764	21	ligand	ligand	NN
cord-001835-0s7ok4uw	1764	22	,	,	,
cord-001835-0s7ok4uw	1764	23	agouti	agouti	NN
cord-001835-0s7ok4uw	1764	24	-	-	HYPH
cord-001835-0s7ok4uw	1764	25	related	relate	VBN
cord-001835-0s7ok4uw	1764	26	peptide	peptide	NN
cord-001835-0s7ok4uw	1764	27	(	(	-LRB-
cord-001835-0s7ok4uw	1764	28	AgRP	AgRP	NNP
cord-001835-0s7ok4uw	1764	29	)	)	-RRB-
cord-001835-0s7ok4uw	1764	30	,	,	,
cord-001835-0s7ok4uw	1764	31	leading	lead	VBG
cord-001835-0s7ok4uw	1764	32	to	to	IN
cord-001835-0s7ok4uw	1764	33	increased	increase	VBN
cord-001835-0s7ok4uw	1764	34	feeding	feeding	NN
cord-001835-0s7ok4uw	1764	35	and	and	CC
cord-001835-0s7ok4uw	1764	36	weight	weight	NN
cord-001835-0s7ok4uw	1764	37	gain	gain	NN
cord-001835-0s7ok4uw	1764	38	.	.	.
cord-001835-0s7ok4uw	1765	1	While	while	IN
cord-001835-0s7ok4uw	1765	2	much	much	JJ
cord-001835-0s7ok4uw	1765	3	research	research	NN
cord-001835-0s7ok4uw	1765	4	has	have	VBZ
cord-001835-0s7ok4uw	1765	5	gone	go	VBN
cord-001835-0s7ok4uw	1765	6	into	into	IN
cord-001835-0s7ok4uw	1765	7	how	how	WRB
cord-001835-0s7ok4uw	1765	8	this	this	DT
cord-001835-0s7ok4uw	1765	9	ligand	ligand	NN
cord-001835-0s7ok4uw	1765	10	exerts	exert	VBZ
cord-001835-0s7ok4uw	1765	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1765	12	effects	effect	NNS
cord-001835-0s7ok4uw	1765	13	at	at	IN
cord-001835-0s7ok4uw	1765	14	the	the	DT
cord-001835-0s7ok4uw	1765	15	receptor	receptor	NN
cord-001835-0s7ok4uw	1765	16	,	,	,
cord-001835-0s7ok4uw	1765	17	less	less	JJR
cord-001835-0s7ok4uw	1765	18	is	be	VBZ
cord-001835-0s7ok4uw	1765	19	known	know	VBN
cord-001835-0s7ok4uw	1765	20	regarding	regard	VBG
cord-001835-0s7ok4uw	1765	21	nonmelanocortin	nonmelanocortin	NNP
cord-001835-0s7ok4uw	1765	22	components	component	NNS
cord-001835-0s7ok4uw	1765	23	of	of	IN
cord-001835-0s7ok4uw	1765	24	the	the	DT
cord-001835-0s7ok4uw	1765	25	pathway	pathway	NN
cord-001835-0s7ok4uw	1765	26	.	.	.
cord-001835-0s7ok4uw	1766	1	Syndecan-3	Syndecan-3	NNP
cord-001835-0s7ok4uw	1766	2	,	,	,
cord-001835-0s7ok4uw	1766	3	a	a	DT
cord-001835-0s7ok4uw	1766	4	heparan	heparan	JJ
cord-001835-0s7ok4uw	1766	5	sulfate	sulfate	NN
cord-001835-0s7ok4uw	1766	6	proteoglycan	proteoglycan	NN
cord-001835-0s7ok4uw	1766	7	,	,	,
cord-001835-0s7ok4uw	1766	8	has	have	VBZ
cord-001835-0s7ok4uw	1766	9	previously	previously	RB
cord-001835-0s7ok4uw	1766	10	been	be	VBN
cord-001835-0s7ok4uw	1766	11	implicated	implicate	VBN
cord-001835-0s7ok4uw	1766	12	in	in	IN
cord-001835-0s7ok4uw	1766	13	potentiating	potentiate	VBG
cord-001835-0s7ok4uw	1766	14	AgRP	agrp	NN
cord-001835-0s7ok4uw	1766	15	antagonism	antagonism	NN
cord-001835-0s7ok4uw	1766	16	,	,	,
cord-001835-0s7ok4uw	1766	17	however	however	RB
cord-001835-0s7ok4uw	1766	18	details	detail	NNS
cord-001835-0s7ok4uw	1766	19	of	of	IN
cord-001835-0s7ok4uw	1766	20	this	this	DT
cord-001835-0s7ok4uw	1766	21	interaction	interaction	NN
cord-001835-0s7ok4uw	1766	22	are	be	VBP
cord-001835-0s7ok4uw	1766	23	unclear	unclear	JJ
cord-001835-0s7ok4uw	1766	24	.	.	.
cord-001835-0s7ok4uw	1767	1	This	this	DT
cord-001835-0s7ok4uw	1767	2	work	work	NN
cord-001835-0s7ok4uw	1767	3	aims	aim	VBZ
cord-001835-0s7ok4uw	1767	4	to	to	TO
cord-001835-0s7ok4uw	1767	5	investigate	investigate	VB
cord-001835-0s7ok4uw	1767	6	the	the	DT
cord-001835-0s7ok4uw	1767	7	role	role	NN
cord-001835-0s7ok4uw	1767	8	of	of	IN
cord-001835-0s7ok4uw	1767	9	syndecans	syndecan	NNS
cord-001835-0s7ok4uw	1767	10	at	at	IN
cord-001835-0s7ok4uw	1767	11	both	both	CC
cord-001835-0s7ok4uw	1767	12	a	a	DT
cord-001835-0s7ok4uw	1767	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	1767	14	level	level	NN
cord-001835-0s7ok4uw	1767	15	and	and	CC
cord-001835-0s7ok4uw	1767	16	in	in	IN
cord-001835-0s7ok4uw	1767	17	vivo	vivo	NNP
cord-001835-0s7ok4uw	1767	18	.	.	.
cord-001835-0s7ok4uw	1768	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1768	2	hypothesize	hypothesize	VBP
cord-001835-0s7ok4uw	1768	3	that	that	IN
cord-001835-0s7ok4uw	1768	4	AgRP	AgRP	NNP
cord-001835-0s7ok4uw	1768	5	binds	bind	VBZ
cord-001835-0s7ok4uw	1768	6	the	the	DT
cord-001835-0s7ok4uw	1768	7	glycosaminoglycan	glycosaminoglycan	NNP
cord-001835-0s7ok4uw	1768	8	(	(	-LRB-
cord-001835-0s7ok4uw	1768	9	GAG	gag	NN
cord-001835-0s7ok4uw	1768	10	)	)	-RRB-
cord-001835-0s7ok4uw	1768	11	components	component	NNS
cord-001835-0s7ok4uw	1768	12	of	of	IN
cord-001835-0s7ok4uw	1768	13	syndecans	syndecans	NNP
cord-001835-0s7ok4uw	1768	14	,	,	,
cord-001835-0s7ok4uw	1768	15	and	and	CC
cord-001835-0s7ok4uw	1768	16	that	that	IN
cord-001835-0s7ok4uw	1768	17	this	this	DT
cord-001835-0s7ok4uw	1768	18	interaction	interaction	NN
cord-001835-0s7ok4uw	1768	19	increases	increase	VBZ
cord-001835-0s7ok4uw	1768	20	the	the	DT
cord-001835-0s7ok4uw	1768	21	local	local	JJ
cord-001835-0s7ok4uw	1768	22	concentration	concentration	NN
cord-001835-0s7ok4uw	1768	23	of	of	IN
cord-001835-0s7ok4uw	1768	24	the	the	DT
cord-001835-0s7ok4uw	1768	25	peptide	peptide	NN
cord-001835-0s7ok4uw	1768	26	near	near	IN
cord-001835-0s7ok4uw	1768	27	MC4R.	MC4R.	NNP
cord-001835-0s7ok4uw	1769	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1769	2	,	,	,
cord-001835-0s7ok4uw	1769	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1769	4	have	have	VBP
cord-001835-0s7ok4uw	1769	5	previously	previously	RB
cord-001835-0s7ok4uw	1769	6	shown	show	VBN
cord-001835-0s7ok4uw	1769	7	that	that	WDT
cord-001835-0s7ok4uw	1769	8	designed	design	VBD
cord-001835-0s7ok4uw	1769	9	positive	positive	JJ
cord-001835-0s7ok4uw	1769	10	charge	charge	NN
cord-001835-0s7ok4uw	1769	11	mutations	mutation	NNS
cord-001835-0s7ok4uw	1769	12	to	to	IN
cord-001835-0s7ok4uw	1769	13	AgRP	AgRP	NNP
cord-001835-0s7ok4uw	1769	14	lead	lead	NN
cord-001835-0s7ok4uw	1769	15	to	to	IN
cord-001835-0s7ok4uw	1769	16	increased	increase	VBN
cord-001835-0s7ok4uw	1769	17	in	in	IN
cord-001835-0s7ok4uw	1769	18	vivo	vivo	NN
cord-001835-0s7ok4uw	1769	19	efficacy	efficacy	NN
cord-001835-0s7ok4uw	1769	20	that	that	WDT
cord-001835-0s7ok4uw	1769	21	is	be	VBZ
cord-001835-0s7ok4uw	1769	22	independent	independent	JJ
cord-001835-0s7ok4uw	1769	23	of	of	IN
cord-001835-0s7ok4uw	1769	24	MC4R	MC4R	NNP
cord-001835-0s7ok4uw	1769	25	activity	activity	NN
cord-001835-0s7ok4uw	1769	26	,	,	,
cord-001835-0s7ok4uw	1769	27	and	and	CC
cord-001835-0s7ok4uw	1769	28	we	-PRON-	PRP
cord-001835-0s7ok4uw	1769	29	hypothesize	hypothesize	VBP
cord-001835-0s7ok4uw	1769	30	that	that	IN
cord-001835-0s7ok4uw	1769	31	this	this	DT
cord-001835-0s7ok4uw	1769	32	is	be	VBZ
cord-001835-0s7ok4uw	1769	33	due	due	JJ
cord-001835-0s7ok4uw	1769	34	to	to	IN
cord-001835-0s7ok4uw	1769	35	greater	great	JJR
cord-001835-0s7ok4uw	1769	36	affinity	affinity	NN
cord-001835-0s7ok4uw	1769	37	for	for	IN
cord-001835-0s7ok4uw	1769	38	the	the	DT
cord-001835-0s7ok4uw	1769	39	negatively	negatively	RB
cord-001835-0s7ok4uw	1769	40	charged	charge	VBN
cord-001835-0s7ok4uw	1769	41	GAGs	gag	NNS
cord-001835-0s7ok4uw	1769	42	.	.	.
cord-001835-0s7ok4uw	1770	1	Using	use	VBG
cord-001835-0s7ok4uw	1770	2	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	1770	3	titration	titration	NN
cord-001835-0s7ok4uw	1770	4	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	1770	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1770	6	have	have	VBP
cord-001835-0s7ok4uw	1770	7	shown	show	VBN
cord-001835-0s7ok4uw	1770	8	tight	tight	JJ
cord-001835-0s7ok4uw	1770	9	binding	binding	NN
cord-001835-0s7ok4uw	1770	10	between	between	IN
cord-001835-0s7ok4uw	1770	11	AgRP	agrp	NN
cord-001835-0s7ok4uw	1770	12	and	and	CC
cord-001835-0s7ok4uw	1770	13	heparan	heparan	NN
cord-001835-0s7ok4uw	1770	14	sulfate	sulfate	NN
cord-001835-0s7ok4uw	1770	15	,	,	,
cord-001835-0s7ok4uw	1770	16	the	the	DT
cord-001835-0s7ok4uw	1770	17	major	major	JJ
cord-001835-0s7ok4uw	1770	18	GAG	gag	NN
cord-001835-0s7ok4uw	1770	19	component	component	NN
cord-001835-0s7ok4uw	1770	20	of	of	IN
cord-001835-0s7ok4uw	1770	21	syndecan-3	syndecan-3	NN
cord-001835-0s7ok4uw	1770	22	,	,	,
cord-001835-0s7ok4uw	1770	23	and	and	CC
cord-001835-0s7ok4uw	1770	24	this	this	DT
cord-001835-0s7ok4uw	1770	25	affinity	affinity	NN
cord-001835-0s7ok4uw	1770	26	is	be	VBZ
cord-001835-0s7ok4uw	1770	27	strengthened	strengthen	VBN
cord-001835-0s7ok4uw	1770	28	by	by	IN
cord-001835-0s7ok4uw	1770	29	additional	additional	JJ
cord-001835-0s7ok4uw	1770	30	peptide	peptide	JJ
cord-001835-0s7ok4uw	1770	31	positive	positive	JJ
cord-001835-0s7ok4uw	1770	32	charge	charge	NN
cord-001835-0s7ok4uw	1770	33	.	.	.
cord-001835-0s7ok4uw	1771	1	Through	through	IN
cord-001835-0s7ok4uw	1771	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	1771	3	,	,	,
cord-001835-0s7ok4uw	1771	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	1771	5	see	see	VBP
cord-001835-0s7ok4uw	1771	6	that	that	IN
cord-001835-0s7ok4uw	1771	7	both	both	DT
cord-001835-0s7ok4uw	1771	8	positively	positively	RB
cord-001835-0s7ok4uw	1771	9	charged	charge	VBN
cord-001835-0s7ok4uw	1771	10	and	and	CC
cord-001835-0s7ok4uw	1771	11	polar	polar	JJ
cord-001835-0s7ok4uw	1771	12	residues	residue	NNS
cord-001835-0s7ok4uw	1771	13	are	be	VBP
cord-001835-0s7ok4uw	1771	14	necessary	necessary	JJ
cord-001835-0s7ok4uw	1771	15	for	for	IN
cord-001835-0s7ok4uw	1771	16	binding	bind	VBG
cord-001835-0s7ok4uw	1771	17	various	various	JJ
cord-001835-0s7ok4uw	1771	18	heparan	heparan	NN
cord-001835-0s7ok4uw	1771	19	sulfate	sulfate	NN
cord-001835-0s7ok4uw	1771	20	polymers	polymer	NNS
cord-001835-0s7ok4uw	1771	21	.	.	.
cord-001835-0s7ok4uw	1772	1	These	these	DT
cord-001835-0s7ok4uw	1772	2	data	datum	NNS
cord-001835-0s7ok4uw	1772	3	implicate	implicate	VBP
cord-001835-0s7ok4uw	1772	4	a	a	DT
cord-001835-0s7ok4uw	1772	5	specific	specific	JJ
cord-001835-0s7ok4uw	1772	6	region	region	NN
cord-001835-0s7ok4uw	1772	7	of	of	IN
cord-001835-0s7ok4uw	1772	8	AgRP	AgRP	NNP
cord-001835-0s7ok4uw	1772	9	that	that	WDT
cord-001835-0s7ok4uw	1772	10	is	be	VBZ
cord-001835-0s7ok4uw	1772	11	not	not	RB
cord-001835-0s7ok4uw	1772	12	required	require	VBN
cord-001835-0s7ok4uw	1772	13	for	for	IN
cord-001835-0s7ok4uw	1772	14	MC4R	MC4R	NNP
cord-001835-0s7ok4uw	1772	15	binding	bind	VBG
cord-001835-0s7ok4uw	1772	16	as	as	IN
cord-001835-0s7ok4uw	1772	17	being	be	VBG
cord-001835-0s7ok4uw	1772	18	necessary	necessary	JJ
cord-001835-0s7ok4uw	1772	19	in	in	IN
cord-001835-0s7ok4uw	1772	20	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1772	21	role	role	NN
cord-001835-0s7ok4uw	1772	22	as	as	IN
cord-001835-0s7ok4uw	1772	23	a	a	DT
cord-001835-0s7ok4uw	1772	24	heparan	heparan	NN
cord-001835-0s7ok4uw	1772	25	sulfate	sulfate	NN
cord-001835-0s7ok4uw	1772	26	binding	bind	VBG
cord-001835-0s7ok4uw	1772	27	protein	protein	NN
cord-001835-0s7ok4uw	1772	28	.	.	.
cord-001835-0s7ok4uw	1773	1	Expanding	expand	VBG
cord-001835-0s7ok4uw	1773	2	on	on	IN
cord-001835-0s7ok4uw	1773	3	these	these	DT
cord-001835-0s7ok4uw	1773	4	findings	finding	NNS
cord-001835-0s7ok4uw	1773	5	,	,	,
cord-001835-0s7ok4uw	1773	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	1773	7	are	be	VBP
cord-001835-0s7ok4uw	1773	8	now	now	RB
cord-001835-0s7ok4uw	1773	9	using	use	VBG
cord-001835-0s7ok4uw	1773	10	a	a	DT
cord-001835-0s7ok4uw	1773	11	syndecan	syndecan	JJ
cord-001835-0s7ok4uw	1773	12	knockout	knockout	NN
cord-001835-0s7ok4uw	1773	13	mouse	mouse	NN
cord-001835-0s7ok4uw	1773	14	line	line	NN
cord-001835-0s7ok4uw	1773	15	to	to	TO
cord-001835-0s7ok4uw	1773	16	explore	explore	VB
cord-001835-0s7ok4uw	1773	17	the	the	DT
cord-001835-0s7ok4uw	1773	18	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1773	19	of	of	IN
cord-001835-0s7ok4uw	1773	20	differential	differential	JJ
cord-001835-0s7ok4uw	1773	21	feeding	feeding	NN
cord-001835-0s7ok4uw	1773	22	in	in	IN
cord-001835-0s7ok4uw	1773	23	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1773	24	designed	design	VBN
cord-001835-0s7ok4uw	1773	25	mutants	mutant	NNS
cord-001835-0s7ok4uw	1773	26	.	.	.
cord-001835-0s7ok4uw	1774	1	Preliminary	preliminary	JJ
cord-001835-0s7ok4uw	1774	2	results	result	NNS
cord-001835-0s7ok4uw	1774	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	1774	4	a	a	DT
cord-001835-0s7ok4uw	1774	5	reduction	reduction	NN
cord-001835-0s7ok4uw	1774	6	in	in	IN
cord-001835-0s7ok4uw	1774	7	weight	weight	NN
cord-001835-0s7ok4uw	1774	8	gain	gain	NN
cord-001835-0s7ok4uw	1774	9	in	in	IN
cord-001835-0s7ok4uw	1774	10	knockouts	knockout	NNS
cord-001835-0s7ok4uw	1774	11	compared	compare	VBN
cord-001835-0s7ok4uw	1774	12	to	to	IN
cord-001835-0s7ok4uw	1774	13	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1774	14	wildtype	wildtype	NN
cord-001835-0s7ok4uw	1774	15	littermates	littermates	NNPS
cord-001835-0s7ok4uw	1774	16	post	post	NNP
cord-001835-0s7ok4uw	1774	17	peptide	peptide	NNP
cord-001835-0s7ok4uw	1774	18	administration	administration	NN
cord-001835-0s7ok4uw	1774	19	.	.	.
cord-001835-0s7ok4uw	1775	1	Collectively	collectively	RB
cord-001835-0s7ok4uw	1775	2	,	,	,
cord-001835-0s7ok4uw	1775	3	these	these	DT
cord-001835-0s7ok4uw	1775	4	data	datum	NNS
cord-001835-0s7ok4uw	1775	5	show	show	VBP
cord-001835-0s7ok4uw	1775	6	that	that	IN
cord-001835-0s7ok4uw	1775	7	the	the	DT
cord-001835-0s7ok4uw	1775	8	physiologically	physiologically	RB
cord-001835-0s7ok4uw	1775	9	relevant	relevant	JJ
cord-001835-0s7ok4uw	1775	10	form	form	NN
cord-001835-0s7ok4uw	1775	11	of	of	IN
cord-001835-0s7ok4uw	1775	12	AgRP	AgRP	NNP
cord-001835-0s7ok4uw	1775	13	,	,	,
cord-001835-0s7ok4uw	1775	14	previously	previously	RB
cord-001835-0s7ok4uw	1775	15	considered	consider	VBN
cord-001835-0s7ok4uw	1775	16	unable	unable	JJ
cord-001835-0s7ok4uw	1775	17	to	to	TO
cord-001835-0s7ok4uw	1775	18	interact	interact	VB
cord-001835-0s7ok4uw	1775	19	with	with	IN
cord-001835-0s7ok4uw	1775	20	syndecans	syndecans	NNP
cord-001835-0s7ok4uw	1775	21	,	,	,
cord-001835-0s7ok4uw	1775	22	is	be	VBZ
cord-001835-0s7ok4uw	1775	23	indeed	indeed	RB
cord-001835-0s7ok4uw	1775	24	a	a	DT
cord-001835-0s7ok4uw	1775	25	heparan	heparan	JJ
cord-001835-0s7ok4uw	1775	26	sulfate	sulfate	NN
cord-001835-0s7ok4uw	1775	27	binding	bind	VBG
cord-001835-0s7ok4uw	1775	28	protein	protein	NN
cord-001835-0s7ok4uw	1775	29	.	.	.
cord-001835-0s7ok4uw	1776	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1776	2	,	,	,
cord-001835-0s7ok4uw	1776	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1776	4	designed	design	VBN
cord-001835-0s7ok4uw	1776	5	mutants	mutant	NNS
cord-001835-0s7ok4uw	1776	6	have	have	VBP
cord-001835-0s7ok4uw	1776	7	differential	differential	JJ
cord-001835-0s7ok4uw	1776	8	affinities	affinity	NNS
cord-001835-0s7ok4uw	1776	9	for	for	IN
cord-001835-0s7ok4uw	1776	10	GAGs	gag	NNS
cord-001835-0s7ok4uw	1776	11	,	,	,
cord-001835-0s7ok4uw	1776	12	with	with	IN
cord-001835-0s7ok4uw	1776	13	increased	increase	VBN
cord-001835-0s7ok4uw	1776	14	affinity	affinity	NN
cord-001835-0s7ok4uw	1776	15	correlating	correlate	VBG
cord-001835-0s7ok4uw	1776	16	to	to	IN
cord-001835-0s7ok4uw	1776	17	increased	increase	VBN
cord-001835-0s7ok4uw	1776	18	feeding	feeding	NN
cord-001835-0s7ok4uw	1776	19	potency	potency	NN
cord-001835-0s7ok4uw	1776	20	.	.	.
cord-001835-0s7ok4uw	1777	1	Finally	finally	RB
cord-001835-0s7ok4uw	1777	2	,	,	,
cord-001835-0s7ok4uw	1777	3	as	as	IN
cord-001835-0s7ok4uw	1777	4	the	the	DT
cord-001835-0s7ok4uw	1777	5	MC4R	MC4R	NNP
cord-001835-0s7ok4uw	1777	6	pathway	pathway	NN
cord-001835-0s7ok4uw	1777	7	is	be	VBZ
cord-001835-0s7ok4uw	1777	8	thought	think	VBN
cord-001835-0s7ok4uw	1777	9	to	to	TO
cord-001835-0s7ok4uw	1777	10	be	be	VB
cord-001835-0s7ok4uw	1777	11	a	a	DT
cord-001835-0s7ok4uw	1777	12	viable	viable	JJ
cord-001835-0s7ok4uw	1777	13	target	target	NN
cord-001835-0s7ok4uw	1777	14	for	for	IN
cord-001835-0s7ok4uw	1777	15	wasting	waste	VBG
cord-001835-0s7ok4uw	1777	16	disorders	disorder	NNS
cord-001835-0s7ok4uw	1777	17	such	such	JJ
cord-001835-0s7ok4uw	1777	18	as	as	IN
cord-001835-0s7ok4uw	1777	19	cachexia	cachexia	NN
cord-001835-0s7ok4uw	1777	20	,	,	,
cord-001835-0s7ok4uw	1777	21	we	-PRON-	PRP
cord-001835-0s7ok4uw	1777	22	are	be	VBP
cord-001835-0s7ok4uw	1777	23	interested	interested	JJ
cord-001835-0s7ok4uw	1777	24	in	in	IN
cord-001835-0s7ok4uw	1777	25	leveraging	leverage	VBG
cord-001835-0s7ok4uw	1777	26	this	this	DT
cord-001835-0s7ok4uw	1777	27	data	datum	NNS
cord-001835-0s7ok4uw	1777	28	to	to	TO
cord-001835-0s7ok4uw	1777	29	improve	improve	VB
cord-001835-0s7ok4uw	1777	30	the	the	DT
cord-001835-0s7ok4uw	1777	31	potency	potency	NN
cord-001835-0s7ok4uw	1777	32	and	and	CC
cord-001835-0s7ok4uw	1777	33	stability	stability	NN
cord-001835-0s7ok4uw	1777	34	of	of	IN
cord-001835-0s7ok4uw	1777	35	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1777	36	designed	design	VBN
cord-001835-0s7ok4uw	1777	37	AgRP	agrp	NN
cord-001835-0s7ok4uw	1777	38	mutants	mutant	NNS
cord-001835-0s7ok4uw	1777	39	.	.	.
cord-001835-0s7ok4uw	1778	1	Taken	take	VBN
cord-001835-0s7ok4uw	1778	2	together	together	RB
cord-001835-0s7ok4uw	1778	3	,	,	,
cord-001835-0s7ok4uw	1778	4	this	this	DT
cord-001835-0s7ok4uw	1778	5	work	work	NN
cord-001835-0s7ok4uw	1778	6	aims	aim	VBZ
cord-001835-0s7ok4uw	1778	7	to	to	TO
cord-001835-0s7ok4uw	1778	8	develop	develop	VB
cord-001835-0s7ok4uw	1778	9	new	new	JJ
cord-001835-0s7ok4uw	1778	10	insights	insight	NNS
cord-001835-0s7ok4uw	1778	11	and	and	CC
cord-001835-0s7ok4uw	1778	12	probe	probe	VB
cord-001835-0s7ok4uw	1778	13	the	the	DT
cord-001835-0s7ok4uw	1778	14	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	1778	15	potential	potential	NN
cord-001835-0s7ok4uw	1778	16	of	of	IN
cord-001835-0s7ok4uw	1778	17	a	a	DT
cord-001835-0s7ok4uw	1778	18	critical	critical	JJ
cord-001835-0s7ok4uw	1778	19	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	1778	20	pathway	pathway	NN
cord-001835-0s7ok4uw	1778	21	.	.	.
cord-001835-0s7ok4uw	1779	1	Evidence	evidence	NN
cord-001835-0s7ok4uw	1779	2	of	of	IN
cord-001835-0s7ok4uw	1779	3	a	a	DT
cord-001835-0s7ok4uw	1779	4	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	1779	5	phenomenon	phenomenon	NN
cord-001835-0s7ok4uw	1779	6	in	in	IN
cord-001835-0s7ok4uw	1779	7	the	the	DT
cord-001835-0s7ok4uw	1779	8	starch	starch	NN
cord-001835-0s7ok4uw	1779	9	binding	bind	VBG
cord-001835-0s7ok4uw	1779	10	domain	domain	NN
cord-001835-0s7ok4uw	1779	11	of	of	IN
cord-001835-0s7ok4uw	1779	12	the	the	DT
cord-001835-0s7ok4uw	1779	13	a	a	DT
cord-001835-0s7ok4uw	1779	14	-	-	HYPH
cord-001835-0s7ok4uw	1779	15	amylase	amylase	NN
cord-001835-0s7ok4uw	1779	16	from	from	IN
cord-001835-0s7ok4uw	1779	17	Lactobacillus	Lactobacillus	NNP
cord-001835-0s7ok4uw	1779	18	amylovorus	amylovorus	NNP
cord-001835-0s7ok4uw	1780	1	Zaira	zaira	NN
cord-001835-0s7ok4uw	1781	1	Esmeralda	Esmeralda	NNP
cord-001835-0s7ok4uw	1781	2	S	S	NNP
cord-001835-0s7ok4uw	1782	1	anchez	anchez	NNP
cord-001835-0s7ok4uw	1782	2	Cuapio	Cuapio	NNP
cord-001835-0s7ok4uw	1782	3	1	1	CD
cord-001835-0s7ok4uw	1782	4	,	,	,
cord-001835-0s7ok4uw	1782	5	Alejandra	Alejandra	NNP
cord-001835-0s7ok4uw	1782	6	Hern	Hern	NNP
cord-001835-0s7ok4uw	1783	1	andez	andez	NNP
cord-001835-0s7ok4uw	1783	2	Santoyo	Santoyo	NNP
cord-001835-0s7ok4uw	1783	3	2	2	CD
cord-001835-0s7ok4uw	1783	4	,	,	,
cord-001835-0s7ok4uw	1783	5	Sergio	Sergio	NNP
cord-001835-0s7ok4uw	1783	6	S	S	NNP
cord-001835-0s7ok4uw	1783	7	anchez	anchez	NN
cord-001835-0s7ok4uw	1783	8	Esquivel	Esquivel	NNP
cord-001835-0s7ok4uw	1783	9	1	1	CD
cord-001835-0s7ok4uw	1783	10	,	,	,
cord-001835-0s7ok4uw	1783	11	Romina	Romina	NNP
cord-001835-0s7ok4uw	1783	12	Rodr	Rodr	NNP
cord-001835-0s7ok4uw	1783	13	ıguez	ıguez	NN
cord-001835-0s7ok4uw	1783	14	Sanoja	Sanoja	NNP
cord-001835-0s7ok4uw	1783	15	1	1	CD
cord-001835-0s7ok4uw	1783	16	1	1	CD
cord-001835-0s7ok4uw	1783	17	Instituto	Instituto	NNP
cord-001835-0s7ok4uw	1783	18	de	de	NNP
cord-001835-0s7ok4uw	1783	19	Investigaciones	Investigaciones	NNP
cord-001835-0s7ok4uw	1783	20	Biom	Biom	NNP
cord-001835-0s7ok4uw	1783	21	edicas	edicas	NN
cord-001835-0s7ok4uw	1783	22	,	,	,
cord-001835-0s7ok4uw	1783	23	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	1783	24	Nacional	Nacional	NNP
cord-001835-0s7ok4uw	1783	25	Aut	Aut	NNP
cord-001835-0s7ok4uw	1783	26	onoma	onoma	NN
cord-001835-0s7ok4uw	1783	27	de	de	NNP
cord-001835-0s7ok4uw	1783	28	M	M	NNP
cord-001835-0s7ok4uw	1783	29	exico	exico	NN
cord-001835-0s7ok4uw	1783	30	,	,	,
cord-001835-0s7ok4uw	1783	31	2	2	CD
cord-001835-0s7ok4uw	1783	32	Instituto	Instituto	NNP
cord-001835-0s7ok4uw	1783	33	de	de	NNP
cord-001835-0s7ok4uw	1783	34	Qu	Qu	NNP
cord-001835-0s7ok4uw	1783	35	ımica	ımica	NNP
cord-001835-0s7ok4uw	1783	36	,	,	,
cord-001835-0s7ok4uw	1784	1	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	1784	2	Nacional	Nacional	NNP
cord-001835-0s7ok4uw	1784	3	Aut	Aut	NNP
cord-001835-0s7ok4uw	1784	4	onoma	onoma	NN
cord-001835-0s7ok4uw	1784	5	de	de	NNP
cord-001835-0s7ok4uw	1784	6	M	M	NNP
cord-001835-0s7ok4uw	1784	7	exico	exico	NN
cord-001835-0s7ok4uw	1785	1	a	a	LS
cord-001835-0s7ok4uw	1785	2	-	-	HYPH
cord-001835-0s7ok4uw	1785	3	amylases	amylase	NNS
cord-001835-0s7ok4uw	1785	4	are	be	VBP
cord-001835-0s7ok4uw	1785	5	glycoside	glycoside	NN
cord-001835-0s7ok4uw	1785	6	-	-	HYPH
cord-001835-0s7ok4uw	1785	7	hydrolases	hydrolase	NNS
cord-001835-0s7ok4uw	1785	8	that	that	WDT
cord-001835-0s7ok4uw	1785	9	catalyze	catalyze	VBP
cord-001835-0s7ok4uw	1785	10	the	the	DT
cord-001835-0s7ok4uw	1785	11	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	1785	12	of	of	IN
cord-001835-0s7ok4uw	1785	13	internal	internal	JJ
cord-001835-0s7ok4uw	1785	14	a-1,4	a-1,4	NNP
cord-001835-0s7ok4uw	1785	15	glycosidic	glycosidic	JJ
cord-001835-0s7ok4uw	1785	16	bonds	bond	NNS
cord-001835-0s7ok4uw	1785	17	in	in	IN
cord-001835-0s7ok4uw	1785	18	starch	starch	NN
cord-001835-0s7ok4uw	1785	19	and	and	CC
cord-001835-0s7ok4uw	1785	20	glycogen	glycogen	NN
cord-001835-0s7ok4uw	1785	21	generating	generate	VBG
cord-001835-0s7ok4uw	1785	22	smaller	small	JJR
cord-001835-0s7ok4uw	1785	23	oligosaccharides	oligosaccharide	NNS
cord-001835-0s7ok4uw	1785	24	(	(	-LRB-
cord-001835-0s7ok4uw	1785	25	1	1	CD
cord-001835-0s7ok4uw	1785	26	)	)	-RRB-
cord-001835-0s7ok4uw	1785	27	.	.	.
cord-001835-0s7ok4uw	1786	1	These	these	DT
cord-001835-0s7ok4uw	1786	2	multidomain	multidomain	NN
cord-001835-0s7ok4uw	1786	3	proteins	protein	NNS
cord-001835-0s7ok4uw	1786	4	contain	contain	VBP
cord-001835-0s7ok4uw	1786	5	a	a	DT
cord-001835-0s7ok4uw	1786	6	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1786	7	barrel	barrel	NN
cord-001835-0s7ok4uw	1786	8	(	(	-LRB-
cord-001835-0s7ok4uw	1786	9	b	b	NN
cord-001835-0s7ok4uw	1786	10	/	/	SYM
cord-001835-0s7ok4uw	1786	11	a)8	a)8	NN
cord-001835-0s7ok4uw	1786	12	and	and	CC
cord-001835-0s7ok4uw	1786	13	,	,	,
cord-001835-0s7ok4uw	1786	14	in	in	IN
cord-001835-0s7ok4uw	1786	15	some	some	DT
cord-001835-0s7ok4uw	1786	16	cases	case	NNS
cord-001835-0s7ok4uw	1786	17	,	,	,
cord-001835-0s7ok4uw	1786	18	one	one	CD
cord-001835-0s7ok4uw	1786	19	or	or	CC
cord-001835-0s7ok4uw	1786	20	more	more	JJR
cord-001835-0s7ok4uw	1786	21	non	non	JJ
cord-001835-0s7ok4uw	1786	22	-	-	JJ
cord-001835-0s7ok4uw	1786	23	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1786	24	domains	domain	NNS
cord-001835-0s7ok4uw	1786	25	whose	whose	WP$
cord-001835-0s7ok4uw	1786	26	function	function	NN
cord-001835-0s7ok4uw	1786	27	is	be	VBZ
cord-001835-0s7ok4uw	1786	28	generally	generally	RB
cord-001835-0s7ok4uw	1786	29	described	describe	VBN
cord-001835-0s7ok4uw	1786	30	as	as	IN
cord-001835-0s7ok4uw	1786	31	carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	1786	32	binding	binding	NN
cord-001835-0s7ok4uw	1786	33	module	module	NN
cord-001835-0s7ok4uw	1786	34	(	(	-LRB-
cord-001835-0s7ok4uw	1786	35	CBM	CBM	NNP
cord-001835-0s7ok4uw	1786	36	)	)	-RRB-
cord-001835-0s7ok4uw	1786	37	and	and	CC
cord-001835-0s7ok4uw	1786	38	particularly	particularly	RB
cord-001835-0s7ok4uw	1786	39	as	as	IN
cord-001835-0s7ok4uw	1786	40	starch	starch	NN
cord-001835-0s7ok4uw	1786	41	-	-	HYPH
cord-001835-0s7ok4uw	1786	42	binding	bind	VBG
cord-001835-0s7ok4uw	1786	43	domains	domain	NNS
cord-001835-0s7ok4uw	1786	44	(	(	-LRB-
cord-001835-0s7ok4uw	1786	45	SBD	SBD	NNP
cord-001835-0s7ok4uw	1786	46	)	)	-RRB-
cord-001835-0s7ok4uw	1786	47	.	.	.
cord-001835-0s7ok4uw	1787	1	The	the	DT
cord-001835-0s7ok4uw	1787	2	SBD	SBD	NNP
cord-001835-0s7ok4uw	1787	3	can	can	MD
cord-001835-0s7ok4uw	1787	4	bind	bind	VB
cord-001835-0s7ok4uw	1787	5	granular	granular	JJ
cord-001835-0s7ok4uw	1787	6	starch	starch	NN
cord-001835-0s7ok4uw	1787	7	increasing	increase	VBG
cord-001835-0s7ok4uw	1787	8	the	the	DT
cord-001835-0s7ok4uw	1787	9	local	local	JJ
cord-001835-0s7ok4uw	1787	10	concentration	concentration	NN
cord-001835-0s7ok4uw	1787	11	of	of	IN
cord-001835-0s7ok4uw	1787	12	substrate	substrate	NN
cord-001835-0s7ok4uw	1787	13	at	at	IN
cord-001835-0s7ok4uw	1787	14	the	the	DT
cord-001835-0s7ok4uw	1787	15	active	active	JJ
cord-001835-0s7ok4uw	1787	16	site	site	NN
cord-001835-0s7ok4uw	1787	17	of	of	IN
cord-001835-0s7ok4uw	1787	18	the	the	DT
cord-001835-0s7ok4uw	1787	19	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1787	20	and	and	CC
cord-001835-0s7ok4uw	1787	21	may	may	MD
cord-001835-0s7ok4uw	1787	22	also	also	RB
cord-001835-0s7ok4uw	1787	23	disrupt	disrupt	VB
cord-001835-0s7ok4uw	1787	24	the	the	DT
cord-001835-0s7ok4uw	1787	25	structure	structure	NN
cord-001835-0s7ok4uw	1787	26	of	of	IN
cord-001835-0s7ok4uw	1787	27	the	the	DT
cord-001835-0s7ok4uw	1787	28	starch	starch	NN
cord-001835-0s7ok4uw	1787	29	surface	surface	NN
cord-001835-0s7ok4uw	1787	30	(	(	-LRB-
cord-001835-0s7ok4uw	1787	31	2	2	CD
cord-001835-0s7ok4uw	1787	32	)	)	-RRB-
cord-001835-0s7ok4uw	1787	33	.	.	.
cord-001835-0s7ok4uw	1788	1	The	the	DT
cord-001835-0s7ok4uw	1788	2	a	a	DT
cord-001835-0s7ok4uw	1788	3	-	-	HYPH
cord-001835-0s7ok4uw	1788	4	amylase	amylase	NN
cord-001835-0s7ok4uw	1788	5	from	from	IN
cord-001835-0s7ok4uw	1788	6	Lactobacillus	Lactobacillus	NNP
cord-001835-0s7ok4uw	1788	7	amylovorus	amylovorus	NNP
cord-001835-0s7ok4uw	1788	8	has	have	VBZ
cord-001835-0s7ok4uw	1788	9	a	a	DT
cord-001835-0s7ok4uw	1788	10	structure	structure	NN
cord-001835-0s7ok4uw	1788	11	that	that	WDT
cord-001835-0s7ok4uw	1788	12	consists	consist	VBZ
cord-001835-0s7ok4uw	1788	13	of	of	IN
cord-001835-0s7ok4uw	1788	14	a	a	DT
cord-001835-0s7ok4uw	1788	15	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1788	16	domain	domain	NN
cord-001835-0s7ok4uw	1788	17	(	(	-LRB-
cord-001835-0s7ok4uw	1788	18	CD	CD	NNP
cord-001835-0s7ok4uw	1788	19	)	)	-RRB-
cord-001835-0s7ok4uw	1788	20	and	and	CC
cord-001835-0s7ok4uw	1788	21	an	an	DT
cord-001835-0s7ok4uw	1788	22	unusual	unusual	JJ
cord-001835-0s7ok4uw	1788	23	carboxy	carboxy	JJ
cord-001835-0s7ok4uw	1788	24	-	-	HYPH
cord-001835-0s7ok4uw	1788	25	terminal	terminal	NN
cord-001835-0s7ok4uw	1788	26	starch	starch	NN
cord-001835-0s7ok4uw	1788	27	-	-	HYPH
cord-001835-0s7ok4uw	1788	28	binding	bind	VBG
cord-001835-0s7ok4uw	1788	29	domain	domain	NN
cord-001835-0s7ok4uw	1788	30	with	with	IN
cord-001835-0s7ok4uw	1788	31	5	5	CD
cord-001835-0s7ok4uw	1788	32	identical	identical	JJ
cord-001835-0s7ok4uw	1788	33	CBMs	cbm	NNS
cord-001835-0s7ok4uw	1788	34	(	(	-LRB-
cord-001835-0s7ok4uw	1788	35	belonging	belong	VBG
cord-001835-0s7ok4uw	1788	36	to	to	IN
cord-001835-0s7ok4uw	1788	37	family	family	NN
cord-001835-0s7ok4uw	1788	38	26	26	CD
cord-001835-0s7ok4uw	1788	39	)	)	-RRB-
cord-001835-0s7ok4uw	1788	40	in	in	IN
cord-001835-0s7ok4uw	1788	41	tandem	tandem	NN
cord-001835-0s7ok4uw	1788	42	(	(	-LRB-
cord-001835-0s7ok4uw	1788	43	3	3	CD
cord-001835-0s7ok4uw	1788	44	)	)	-RRB-
cord-001835-0s7ok4uw	1788	45	.	.	.
cord-001835-0s7ok4uw	1789	1	Each	each	DT
cord-001835-0s7ok4uw	1789	2	repeat	repeat	NN
cord-001835-0s7ok4uw	1789	3	acts	act	VBZ
cord-001835-0s7ok4uw	1789	4	as	as	IN
cord-001835-0s7ok4uw	1789	5	an	an	DT
cord-001835-0s7ok4uw	1789	6	independent	independent	JJ
cord-001835-0s7ok4uw	1789	7	fixing	fixing	NN
cord-001835-0s7ok4uw	1789	8	module	module	NN
cord-001835-0s7ok4uw	1789	9	with	with	IN
cord-001835-0s7ok4uw	1789	10	an	an	DT
cord-001835-0s7ok4uw	1789	11	additive	additive	NN
cord-001835-0s7ok4uw	1789	12	or	or	CC
cord-001835-0s7ok4uw	1789	13	synergic	synergic	JJ
cord-001835-0s7ok4uw	1789	14	effect	effect	NN
cord-001835-0s7ok4uw	1789	15	between	between	IN
cord-001835-0s7ok4uw	1789	16	the	the	DT
cord-001835-0s7ok4uw	1789	17	units	unit	NNS
cord-001835-0s7ok4uw	1789	18	(	(	-LRB-
cord-001835-0s7ok4uw	1789	19	4	4	CD
cord-001835-0s7ok4uw	1789	20	)	)	-RRB-
cord-001835-0s7ok4uw	1789	21	.	.	.
cord-001835-0s7ok4uw	1790	1	When	when	WRB
cord-001835-0s7ok4uw	1790	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	1790	3	stored	store	VBD
cord-001835-0s7ok4uw	1790	4	pure	pure	JJ
cord-001835-0s7ok4uw	1790	5	SBD	SBD	NNP
cord-001835-0s7ok4uw	1790	6	from	from	IN
cord-001835-0s7ok4uw	1790	7	L.	L.	NNP
cord-001835-0s7ok4uw	1790	8	amylovorus	amylovorus	NNP
cord-001835-0s7ok4uw	1790	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	1790	10	found	find	VBD
cord-001835-0s7ok4uw	1790	11	multiple	multiple	JJ
cord-001835-0s7ok4uw	1790	12	forms	form	NNS
cord-001835-0s7ok4uw	1790	13	of	of	IN
cord-001835-0s7ok4uw	1790	14	low	low	JJ
cord-001835-0s7ok4uw	1790	15	molecular	molecular	JJ
cord-001835-0s7ok4uw	1790	16	weight	weight	NN
cord-001835-0s7ok4uw	1790	17	with	with	IN
cord-001835-0s7ok4uw	1790	18	a	a	DT
cord-001835-0s7ok4uw	1790	19	constant	constant	JJ
cord-001835-0s7ok4uw	1790	20	pattern	pattern	NN
cord-001835-0s7ok4uw	1790	21	,	,	,
cord-001835-0s7ok4uw	1790	22	which	which	WDT
cord-001835-0s7ok4uw	1790	23	does	do	VBZ
cord-001835-0s7ok4uw	1790	24	not	not	RB
cord-001835-0s7ok4uw	1790	25	correspond	correspond	VB
cord-001835-0s7ok4uw	1790	26	to	to	IN
cord-001835-0s7ok4uw	1790	27	random	random	JJ
cord-001835-0s7ok4uw	1790	28	degradation	degradation	NN
cord-001835-0s7ok4uw	1790	29	.	.	.
cord-001835-0s7ok4uw	1791	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	1791	2	,	,	,
cord-001835-0s7ok4uw	1791	3	when	when	WRB
cord-001835-0s7ok4uw	1791	4	the	the	DT
cord-001835-0s7ok4uw	1791	5	protein	protein	NN
cord-001835-0s7ok4uw	1791	6	is	be	VBZ
cord-001835-0s7ok4uw	1791	7	stored	store	VBN
cord-001835-0s7ok4uw	1791	8	at	at	IN
cord-001835-0s7ok4uw	1791	9	pH	pH	NNP
cord-001835-0s7ok4uw	1791	10	close	close	JJ
cord-001835-0s7ok4uw	1791	11	to	to	IN
cord-001835-0s7ok4uw	1791	12	5	5	CD
cord-001835-0s7ok4uw	1791	13	and	and	CC
cord-001835-0s7ok4uw	1791	14	EDTA	EDTA	NNP
cord-001835-0s7ok4uw	1791	15	is	be	VBZ
cord-001835-0s7ok4uw	1791	16	added	add	VBN
cord-001835-0s7ok4uw	1791	17	,	,	,
cord-001835-0s7ok4uw	1791	18	such	such	JJ
cord-001835-0s7ok4uw	1791	19	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	1791	20	appears	appear	VBZ
cord-001835-0s7ok4uw	1791	21	to	to	TO
cord-001835-0s7ok4uw	1791	22	decrease	decrease	VB
cord-001835-0s7ok4uw	1791	23	.	.	.
cord-001835-0s7ok4uw	1792	1	So	so	RB
cord-001835-0s7ok4uw	1792	2	far	far	RB
cord-001835-0s7ok4uw	1792	3	,	,	,
cord-001835-0s7ok4uw	1792	4	there	there	EX
cord-001835-0s7ok4uw	1792	5	is	be	VBZ
cord-001835-0s7ok4uw	1792	6	little	little	JJ
cord-001835-0s7ok4uw	1792	7	information	information	NN
cord-001835-0s7ok4uw	1792	8	about	about	IN
cord-001835-0s7ok4uw	1792	9	the	the	DT
cord-001835-0s7ok4uw	1792	10	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	1792	11	process	process	NN
cord-001835-0s7ok4uw	1792	12	of	of	IN
cord-001835-0s7ok4uw	1792	13	amylases	amylase	NNS
cord-001835-0s7ok4uw	1792	14	and	and	CC
cord-001835-0s7ok4uw	1792	15	the	the	DT
cord-001835-0s7ok4uw	1792	16	nature	nature	NN
cord-001835-0s7ok4uw	1792	17	of	of	IN
cord-001835-0s7ok4uw	1792	18	it	-PRON-	PRP
cord-001835-0s7ok4uw	1792	19	.	.	.
cord-001835-0s7ok4uw	1793	1	Here	here	RB
cord-001835-0s7ok4uw	1793	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	1793	3	show	show	VBP
cord-001835-0s7ok4uw	1793	4	that	that	IN
cord-001835-0s7ok4uw	1793	5	divalent	divalent	JJ
cord-001835-0s7ok4uw	1793	6	ions	ion	NNS
cord-001835-0s7ok4uw	1793	7	induce	induce	VBP
cord-001835-0s7ok4uw	1793	8	a	a	DT
cord-001835-0s7ok4uw	1793	9	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	1793	10	cleavage	cleavage	NN
cord-001835-0s7ok4uw	1793	11	of	of	IN
cord-001835-0s7ok4uw	1793	12	the	the	DT
cord-001835-0s7ok4uw	1793	13	SBD	SBD	NNP
cord-001835-0s7ok4uw	1793	14	,	,	,
cord-001835-0s7ok4uw	1793	15	raising	raise	VBG
cord-001835-0s7ok4uw	1793	16	the	the	DT
cord-001835-0s7ok4uw	1793	17	possibility	possibility	NN
cord-001835-0s7ok4uw	1793	18	of	of	IN
cord-001835-0s7ok4uw	1793	19	an	an	DT
cord-001835-0s7ok4uw	1793	20	autoproteolytic	autoproteolytic	JJ
cord-001835-0s7ok4uw	1793	21	activity	activity	NN
cord-001835-0s7ok4uw	1793	22	.	.	.
cord-001835-0s7ok4uw	1794	1	Acknowledgments	acknowledgment	NNS
cord-001835-0s7ok4uw	1794	2	:	:	:
cord-001835-0s7ok4uw	1794	3	This	this	DT
cord-001835-0s7ok4uw	1794	4	work	work	NN
cord-001835-0s7ok4uw	1794	5	is	be	VBZ
cord-001835-0s7ok4uw	1794	6	supported	support	VBN
cord-001835-0s7ok4uw	1794	7	by	by	IN
cord-001835-0s7ok4uw	1794	8	grants	grant	NNS
cord-001835-0s7ok4uw	1794	9	PAPIIT	PAPIIT	NNP
cord-001835-0s7ok4uw	1794	10	IN222113	IN222113	NNP
cord-001835-0s7ok4uw	1794	11	-	-	HYPH
cord-001835-0s7ok4uw	1794	12	3	3	NNP
cord-001835-0s7ok4uw	1794	13	and	and	CC
cord-001835-0s7ok4uw	1794	14	CONACyT	CONACyT	NNP
cord-001835-0s7ok4uw	1794	15	131149	131149	CD
cord-001835-0s7ok4uw	1794	16	.	.	.
cord-001835-0s7ok4uw	1795	1	S	S	NNP
cord-001835-0s7ok4uw	1795	2	anchez	anchez	NNP
cord-001835-0s7ok4uw	1795	3	Cuapio	Cuapio	NNP
cord-001835-0s7ok4uw	1795	4	Z	Z	NNP
cord-001835-0s7ok4uw	1795	5	is	be	VBZ
cord-001835-0s7ok4uw	1795	6	supported	support	VBN
cord-001835-0s7ok4uw	1795	7	by	by	IN
cord-001835-0s7ok4uw	1795	8	a	a	DT
cord-001835-0s7ok4uw	1795	9	personal	personal	JJ
cord-001835-0s7ok4uw	1795	10	grant	grant	NN
cord-001835-0s7ok4uw	1795	11	from	from	IN
cord-001835-0s7ok4uw	1795	12	Consejo	Consejo	NNP
cord-001835-0s7ok4uw	1795	13	Nacional	Nacional	NNP
cord-001835-0s7ok4uw	1795	14	de	de	NNP
cord-001835-0s7ok4uw	1795	15	Ciencia	Ciencia	NNP
cord-001835-0s7ok4uw	1795	16	y	y	NNP
cord-001835-0s7ok4uw	1795	17	Tecnolog	Tecnolog	NNP
cord-001835-0s7ok4uw	1795	18	ıa	ıa	NNS
cord-001835-0s7ok4uw	1795	19	,	,	,
cord-001835-0s7ok4uw	1795	20	M	M	NNP
cord-001835-0s7ok4uw	1795	21	exico	exico	NN
cord-001835-0s7ok4uw	1795	22	.	.	.
cord-001835-0s7ok4uw	1795	23	 	 	_SP
cord-001835-0s7ok4uw	1796	1	Unnatural	unnatural	JJ
cord-001835-0s7ok4uw	1796	2	amino	amino	NN
cord-001835-0s7ok4uw	1796	3	acid	acid	NN
cord-001835-0s7ok4uw	1796	4	and	and	CC
cord-001835-0s7ok4uw	1796	5	related	related	JJ
cord-001835-0s7ok4uw	1796	6	methods	method	NNS
cord-001835-0s7ok4uw	1796	7	provided	provide	VBD
cord-001835-0s7ok4uw	1796	8	a	a	DT
cord-001835-0s7ok4uw	1796	9	special	special	JJ
cord-001835-0s7ok4uw	1796	10	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1796	11	to	to	TO
cord-001835-0s7ok4uw	1796	12	implement	implement	VB
cord-001835-0s7ok4uw	1796	13	site	site	NN
cord-001835-0s7ok4uw	1796	14	-	-	HYPH
cord-001835-0s7ok4uw	1796	15	specific	specific	JJ
cord-001835-0s7ok4uw	1796	16	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1796	17	active	active	JJ
cord-001835-0s7ok4uw	1796	18	probe	probe	NN
cord-001835-0s7ok4uw	1796	19	incorporation	incorporation	NN
cord-001835-0s7ok4uw	1796	20	in	in	IN
cord-001835-0s7ok4uw	1796	21	a	a	DT
cord-001835-0s7ok4uw	1796	22	specific	specific	JJ
cord-001835-0s7ok4uw	1796	23	membrane	membrane	NN
cord-001835-0s7ok4uw	1796	24	protein	protein	NN
cord-001835-0s7ok4uw	1796	25	in	in	IN
cord-001835-0s7ok4uw	1796	26	cells	cell	NNS
cord-001835-0s7ok4uw	1796	27	.	.	.
cord-001835-0s7ok4uw	1797	1	The	the	DT
cord-001835-0s7ok4uw	1797	2	site	site	NN
cord-001835-0s7ok4uw	1797	3	specific	specific	JJ
cord-001835-0s7ok4uw	1797	4	incorporation	incorporation	NN
cord-001835-0s7ok4uw	1797	5	resulted	result	VBD
cord-001835-0s7ok4uw	1797	6	in	in	IN
cord-001835-0s7ok4uw	1797	7	a	a	DT
cord-001835-0s7ok4uw	1797	8	single	single	JJ
cord-001835-0s7ok4uw	1797	9	signal	signal	NN
cord-001835-0s7ok4uw	1797	10	during	during	IN
cord-001835-0s7ok4uw	1797	11	acquisition	acquisition	NN
cord-001835-0s7ok4uw	1797	12	,	,	,
cord-001835-0s7ok4uw	1797	13	resulting	result	VBG
cord-001835-0s7ok4uw	1797	14	in	in	IN
cord-001835-0s7ok4uw	1797	15	unambiguous	unambiguous	JJ
cord-001835-0s7ok4uw	1797	16	signal	signal	NN
cord-001835-0s7ok4uw	1797	17	assignment	assignment	NN
cord-001835-0s7ok4uw	1797	18	.	.	.
cord-001835-0s7ok4uw	1798	1	The	the	DT
cord-001835-0s7ok4uw	1798	2	protein	protein	NN
cord-001835-0s7ok4uw	1798	3	specific	specific	JJ
cord-001835-0s7ok4uw	1798	4	labeling	labeling	NN
cord-001835-0s7ok4uw	1798	5	makes	make	VBZ
cord-001835-0s7ok4uw	1798	6	it	-PRON-	PRP
cord-001835-0s7ok4uw	1798	7	possible	possible	JJ
cord-001835-0s7ok4uw	1798	8	for	for	IN
cord-001835-0s7ok4uw	1798	9	in	in	IN
cord-001835-0s7ok4uw	1798	10	situ	situ	JJ
cord-001835-0s7ok4uw	1798	11	membrane	membrane	NN
cord-001835-0s7ok4uw	1798	12	protein	protein	NN
cord-001835-0s7ok4uw	1798	13	analysis	analysis	NN
cord-001835-0s7ok4uw	1798	14	using	use	VBG
cord-001835-0s7ok4uw	1798	15	NMR	NMR	NNP
cord-001835-0s7ok4uw	1798	16	or	or	CC
cord-001835-0s7ok4uw	1798	17	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1798	18	detection	detection	NN
cord-001835-0s7ok4uw	1798	19	.	.	.
cord-001835-0s7ok4uw	1799	1	The	the	DT
cord-001835-0s7ok4uw	1799	2	19F	19f	NN
cord-001835-0s7ok4uw	1799	3	containing	contain	VBG
cord-001835-0s7ok4uw	1799	4	unnatural	unnatural	JJ
cord-001835-0s7ok4uw	1799	5	amino	amino	NN
cord-001835-0s7ok4uw	1799	6	acid	acid	NN
cord-001835-0s7ok4uw	1799	7	incorporation	incorporation	NN
cord-001835-0s7ok4uw	1799	8	has	have	VBZ
cord-001835-0s7ok4uw	1799	9	been	be	VBN
cord-001835-0s7ok4uw	1799	10	applied	apply	VBN
cord-001835-0s7ok4uw	1799	11	for	for	IN
cord-001835-0s7ok4uw	1799	12	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	1799	13	studies	study	NNS
cord-001835-0s7ok4uw	1799	14	of	of	IN
cord-001835-0s7ok4uw	1799	15	transporters	transporter	NNS
cord-001835-0s7ok4uw	1799	16	in	in	IN
cord-001835-0s7ok4uw	1799	17	native	native	JJ
cord-001835-0s7ok4uw	1799	18	lipid	lipid	NN
cord-001835-0s7ok4uw	1799	19	membrane	membrane	NN
cord-001835-0s7ok4uw	1799	20	,	,	,
cord-001835-0s7ok4uw	1799	21	and	and	CC
cord-001835-0s7ok4uw	1799	22	the	the	DT
cord-001835-0s7ok4uw	1799	23	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	1799	24	quantification	quantification	NN
cord-001835-0s7ok4uw	1799	25	analysis	analysis	NN
cord-001835-0s7ok4uw	1799	26	for	for	IN
cord-001835-0s7ok4uw	1799	27	Tyrosine	Tyrosine	NNP
cord-001835-0s7ok4uw	1799	28	kinase	kinase	NN
cord-001835-0s7ok4uw	1799	29	in	in	IN
cord-001835-0s7ok4uw	1799	30	native	native	JJ
cord-001835-0s7ok4uw	1799	31	lipid	lipid	NN
cord-001835-0s7ok4uw	1799	32	membrane	membrane	NN
cord-001835-0s7ok4uw	1799	33	with	with	IN
cord-001835-0s7ok4uw	1799	34	the	the	DT
cord-001835-0s7ok4uw	1799	35	aid	aid	NN
cord-001835-0s7ok4uw	1799	36	of	of	IN
cord-001835-0s7ok4uw	1799	37	lipodisc	lipodisc	NNP
cord-001835-0s7ok4uw	1799	38	.	.	.
cord-001835-0s7ok4uw	1800	1	The	the	DT
cord-001835-0s7ok4uw	1800	2	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	1800	3	unnatural	unnatural	JJ
cord-001835-0s7ok4uw	1800	4	amino	amino	NN
cord-001835-0s7ok4uw	1800	5	acid	acid	NN
cord-001835-0s7ok4uw	1800	6	incorporation	incorporation	NN
cord-001835-0s7ok4uw	1800	7	enabled	enable	VBD
cord-001835-0s7ok4uw	1800	8	the	the	DT
cord-001835-0s7ok4uw	1800	9	site	site	NN
cord-001835-0s7ok4uw	1800	10	-	-	HYPH
cord-001835-0s7ok4uw	1800	11	specific	specific	JJ
cord-001835-0s7ok4uw	1800	12	channel	channel	NN
cord-001835-0s7ok4uw	1800	13	responses	response	NNS
cord-001835-0s7ok4uw	1800	14	analysis	analysis	NN
cord-001835-0s7ok4uw	1800	15	upon	upon	IN
cord-001835-0s7ok4uw	1800	16	ligand	ligand	NN
cord-001835-0s7ok4uw	1800	17	binding	binding	NN
cord-001835-0s7ok4uw	1800	18	in	in	IN
cord-001835-0s7ok4uw	1800	19	a	a	DT
cord-001835-0s7ok4uw	1800	20	single	single	JJ
cord-001835-0s7ok4uw	1800	21	cell	cell	NN
cord-001835-0s7ok4uw	1800	22	.	.	.
cord-001835-0s7ok4uw	1801	1	Heather	Heather	NNP
cord-001835-0s7ok4uw	1801	2	Wiebe	Wiebe	NNP
cord-001835-0s7ok4uw	1801	3	1	1	CD
cord-001835-0s7ok4uw	1801	4	,	,	,
cord-001835-0s7ok4uw	1801	5	Noham	Noham	NNP
cord-001835-0s7ok4uw	1801	6	Weinberg	Weinberg	NNP
cord-001835-0s7ok4uw	1801	7	1,2	1,2	CD
cord-001835-0s7ok4uw	1801	8	1	1	CD
cord-001835-0s7ok4uw	1801	9	Department	Department	NNP
cord-001835-0s7ok4uw	1801	10	of	of	IN
cord-001835-0s7ok4uw	1801	11	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	1801	12	,	,	,
cord-001835-0s7ok4uw	1801	13	Simon	Simon	NNP
cord-001835-0s7ok4uw	1801	14	Fraser	Fraser	NNP
cord-001835-0s7ok4uw	1801	15	University	University	NNP
cord-001835-0s7ok4uw	1801	16	,	,	,
cord-001835-0s7ok4uw	1801	17	2	2	CD
cord-001835-0s7ok4uw	1801	18	Department	Department	NNP
cord-001835-0s7ok4uw	1801	19	of	of	IN
cord-001835-0s7ok4uw	1801	20	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	1801	21	,	,	,
cord-001835-0s7ok4uw	1801	22	University	University	NNP
cord-001835-0s7ok4uw	1801	23	of	of	IN
cord-001835-0s7ok4uw	1801	24	the	the	DT
cord-001835-0s7ok4uw	1801	25	Fraser	Fraser	NNP
cord-001835-0s7ok4uw	1801	26	Valley	Valley	NNP
cord-001835-0s7ok4uw	1802	1	The	the	DT
cord-001835-0s7ok4uw	1802	2	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1802	3	by	by	IN
cord-001835-0s7ok4uw	1802	4	which	which	WDT
cord-001835-0s7ok4uw	1802	5	conformational	conformational	JJ
cord-001835-0s7ok4uw	1802	6	changes	change	NNS
cord-001835-0s7ok4uw	1802	7	,	,	,
cord-001835-0s7ok4uw	1802	8	particularly	particularly	RB
cord-001835-0s7ok4uw	1802	9	folding	fold	VBG
cord-001835-0s7ok4uw	1802	10	and	and	CC
cord-001835-0s7ok4uw	1802	11	unfolding	unfolding	NN
cord-001835-0s7ok4uw	1802	12	,	,	,
cord-001835-0s7ok4uw	1802	13	occur	occur	VBP
cord-001835-0s7ok4uw	1802	14	in	in	IN
cord-001835-0s7ok4uw	1802	15	proteins	protein	NNS
cord-001835-0s7ok4uw	1802	16	and	and	CC
cord-001835-0s7ok4uw	1802	17	other	other	JJ
cord-001835-0s7ok4uw	1802	18	biopolymers	biopolymer	NNS
cord-001835-0s7ok4uw	1802	19	has	have	VBZ
cord-001835-0s7ok4uw	1802	20	been	be	VBN
cord-001835-0s7ok4uw	1802	21	widely	widely	RB
cord-001835-0s7ok4uw	1802	22	discussed	discuss	VBN
cord-001835-0s7ok4uw	1802	23	in	in	IN
cord-001835-0s7ok4uw	1802	24	the	the	DT
cord-001835-0s7ok4uw	1802	25	literature	literature	NN
cord-001835-0s7ok4uw	1802	26	.	.	.
cord-001835-0s7ok4uw	1803	1	Molecular	molecular	JJ
cord-001835-0s7ok4uw	1803	2	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	1803	3	(	(	-LRB-
cord-001835-0s7ok4uw	1803	4	MD	MD	NNP
cord-001835-0s7ok4uw	1803	5	)	)	-RRB-
cord-001835-0s7ok4uw	1803	6	simulations	simulation	NNS
cord-001835-0s7ok4uw	1803	7	of	of	IN
cord-001835-0s7ok4uw	1803	8	protein	protein	NN
cord-001835-0s7ok4uw	1803	9	folding	folding	NN
cord-001835-0s7ok4uw	1803	10	present	present	VBP
cord-001835-0s7ok4uw	1803	11	a	a	DT
cord-001835-0s7ok4uw	1803	12	formidable	formidable	JJ
cord-001835-0s7ok4uw	1803	13	challenge	challenge	NN
cord-001835-0s7ok4uw	1803	14	since	since	IN
cord-001835-0s7ok4uw	1803	15	these	these	DT
cord-001835-0s7ok4uw	1803	16	conformational	conformational	JJ
cord-001835-0s7ok4uw	1803	17	changes	change	NNS
cord-001835-0s7ok4uw	1803	18	occur	occur	VBP
cord-001835-0s7ok4uw	1803	19	on	on	IN
cord-001835-0s7ok4uw	1803	20	a	a	DT
cord-001835-0s7ok4uw	1803	21	time	time	NN
cord-001835-0s7ok4uw	1803	22	scale	scale	NN
cord-001835-0s7ok4uw	1803	23	much	much	RB
cord-001835-0s7ok4uw	1803	24	longer	long	RBR
cord-001835-0s7ok4uw	1803	25	than	than	IN
cord-001835-0s7ok4uw	1803	26	what	what	WP
cord-001835-0s7ok4uw	1803	27	can	can	MD
cord-001835-0s7ok4uw	1803	28	be	be	VB
cord-001835-0s7ok4uw	1803	29	afforded	afford	VBN
cord-001835-0s7ok4uw	1803	30	at	at	IN
cord-001835-0s7ok4uw	1803	31	the	the	DT
cord-001835-0s7ok4uw	1803	32	current	current	JJ
cord-001835-0s7ok4uw	1803	33	level	level	NN
cord-001835-0s7ok4uw	1803	34	of	of	IN
cord-001835-0s7ok4uw	1803	35	computational	computational	JJ
cord-001835-0s7ok4uw	1803	36	technology	technology	NN
cord-001835-0s7ok4uw	1803	37	.	.	.
cord-001835-0s7ok4uw	1804	1	Transition	transition	NN
cord-001835-0s7ok4uw	1804	2	state	state	NN
cord-001835-0s7ok4uw	1804	3	(	(	-LRB-
cord-001835-0s7ok4uw	1804	4	TS	TS	NNP
cord-001835-0s7ok4uw	1804	5	)	)	-RRB-
cord-001835-0s7ok4uw	1804	6	theory	theory	NN
cord-001835-0s7ok4uw	1804	7	offers	offer	VBZ
cord-001835-0s7ok4uw	1804	8	a	a	DT
cord-001835-0s7ok4uw	1804	9	more	more	RBR
cord-001835-0s7ok4uw	1804	10	economic	economic	JJ
cord-001835-0s7ok4uw	1804	11	description	description	NN
cord-001835-0s7ok4uw	1804	12	of	of	IN
cord-001835-0s7ok4uw	1804	13	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	1804	14	properties	property	NNS
cord-001835-0s7ok4uw	1804	15	of	of	IN
cord-001835-0s7ok4uw	1804	16	a	a	DT
cord-001835-0s7ok4uw	1804	17	reaction	reaction	NN
cord-001835-0s7ok4uw	1804	18	system	system	NN
cord-001835-0s7ok4uw	1804	19	by	by	IN
cord-001835-0s7ok4uw	1804	20	relating	relate	VBG
cord-001835-0s7ok4uw	1804	21	them	-PRON-	PRP
cord-001835-0s7ok4uw	1804	22	to	to	IN
cord-001835-0s7ok4uw	1804	23	the	the	DT
cord-001835-0s7ok4uw	1804	24	properties	property	NNS
cord-001835-0s7ok4uw	1804	25	of	of	IN
cord-001835-0s7ok4uw	1804	26	the	the	DT
cord-001835-0s7ok4uw	1804	27	TS	TS	NNP
cord-001835-0s7ok4uw	1804	28	,	,	,
cord-001835-0s7ok4uw	1804	29	or	or	CC
cord-001835-0s7ok4uw	1804	30	for	for	IN
cord-001835-0s7ok4uw	1804	31	flexible	flexible	JJ
cord-001835-0s7ok4uw	1804	32	systems	system	NNS
cord-001835-0s7ok4uw	1804	33	,	,	,
cord-001835-0s7ok4uw	1804	34	the	the	DT
cord-001835-0s7ok4uw	1804	35	TS	TS	NNP
cord-001835-0s7ok4uw	1804	36	ensemble	ensemble	NN
cord-001835-0s7ok4uw	1804	37	(	(	-LRB-
cord-001835-0s7ok4uw	1804	38	TSE	TSE	NNP
cord-001835-0s7ok4uw	1804	39	)	)	-RRB-
cord-001835-0s7ok4uw	1804	40	.	.	.
cord-001835-0s7ok4uw	1805	1	The	the	DT
cord-001835-0s7ok4uw	1805	2	application	application	NN
cord-001835-0s7ok4uw	1805	3	of	of	IN
cord-001835-0s7ok4uw	1805	4	TS	TS	NNP
cord-001835-0s7ok4uw	1805	5	theory	theory	NN
cord-001835-0s7ok4uw	1805	6	to	to	IN
cord-001835-0s7ok4uw	1805	7	protein	protein	NN
cord-001835-0s7ok4uw	1805	8	folding	folding	NN
cord-001835-0s7ok4uw	1805	9	is	be	VBZ
cord-001835-0s7ok4uw	1805	10	limited	limit	VBN
cord-001835-0s7ok4uw	1805	11	by	by	IN
cord-001835-0s7ok4uw	1805	12	ambiguity	ambiguity	NN
cord-001835-0s7ok4uw	1805	13	in	in	IN
cord-001835-0s7ok4uw	1805	14	the	the	DT
cord-001835-0s7ok4uw	1805	15	definition	definition	NN
cord-001835-0s7ok4uw	1805	16	of	of	IN
cord-001835-0s7ok4uw	1805	17	the	the	DT
cord-001835-0s7ok4uw	1805	18	TSE	TSE	NNP
cord-001835-0s7ok4uw	1805	19	,	,	,
cord-001835-0s7ok4uw	1805	20	although	although	IN
cord-001835-0s7ok4uw	1805	21	the	the	DT
cord-001835-0s7ok4uw	1805	22	experimentally	experimentally	RB
cord-001835-0s7ok4uw	1805	23	observed	observe	VBN
cord-001835-0s7ok4uw	1805	24	first	first	JJ
cord-001835-0s7ok4uw	1805	25	-	-	HYPH
cord-001835-0s7ok4uw	1805	26	order	order	NN
cord-001835-0s7ok4uw	1805	27	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	1805	28	for	for	IN
cord-001835-0s7ok4uw	1805	29	folding	fold	VBG
cord-001835-0s7ok4uw	1805	30	of	of	IN
cord-001835-0s7ok4uw	1805	31	small	small	JJ
cord-001835-0s7ok4uw	1805	32	single	single	JJ
cord-001835-0s7ok4uw	1805	33	-	-	HYPH
cord-001835-0s7ok4uw	1805	34	domain	domain	NN
cord-001835-0s7ok4uw	1805	35	proteins	protein	NNS
cord-001835-0s7ok4uw	1805	36	lends	lend	VBZ
cord-001835-0s7ok4uw	1805	37	itself	-PRON-	PRP
cord-001835-0s7ok4uw	1805	38	to	to	IN
cord-001835-0s7ok4uw	1805	39	interpretation	interpretation	NN
cord-001835-0s7ok4uw	1805	40	by	by	IN
cord-001835-0s7ok4uw	1805	41	this	this	DT
cord-001835-0s7ok4uw	1805	42	theory	theory	NN
cord-001835-0s7ok4uw	1805	43	.	.	.
cord-001835-0s7ok4uw	1806	1	The	the	DT
cord-001835-0s7ok4uw	1806	2	pressure	pressure	NN
cord-001835-0s7ok4uw	1806	3	dependences	dependence	NNS
cord-001835-0s7ok4uw	1806	4	of	of	IN
cord-001835-0s7ok4uw	1806	5	the	the	DT
cord-001835-0s7ok4uw	1806	6	folding	folding	NN
cord-001835-0s7ok4uw	1806	7	rate	rate	NN
cord-001835-0s7ok4uw	1806	8	constant	constant	NN
cord-001835-0s7ok4uw	1806	9	can	can	MD
cord-001835-0s7ok4uw	1806	10	be	be	VB
cord-001835-0s7ok4uw	1806	11	used	use	VBN
cord-001835-0s7ok4uw	1806	12	to	to	TO
cord-001835-0s7ok4uw	1806	13	obtain	obtain	VB
cord-001835-0s7ok4uw	1806	14	activation	activation	NN
cord-001835-0s7ok4uw	1806	15	energies	energy	NNS
cord-001835-0s7ok4uw	1806	16	and	and	CC
cord-001835-0s7ok4uw	1806	17	activation	activation	NN
cord-001835-0s7ok4uw	1806	18	volumes	volume	NNS
cord-001835-0s7ok4uw	1806	19	,	,	,
cord-001835-0s7ok4uw	1806	20	which	which	WDT
cord-001835-0s7ok4uw	1806	21	are	be	VBP
cord-001835-0s7ok4uw	1806	22	rationalized	rationalize	VBN
cord-001835-0s7ok4uw	1806	23	as	as	IN
cord-001835-0s7ok4uw	1806	24	the	the	DT
cord-001835-0s7ok4uw	1806	25	properties	property	NNS
cord-001835-0s7ok4uw	1806	26	of	of	IN
cord-001835-0s7ok4uw	1806	27	the	the	DT
cord-001835-0s7ok4uw	1806	28	folding	folding	NN
cord-001835-0s7ok4uw	1806	29	TSE	TSE	NNP
cord-001835-0s7ok4uw	1806	30	.	.	.
cord-001835-0s7ok4uw	1807	1	The	the	DT
cord-001835-0s7ok4uw	1807	2	large	large	JJ
cord-001835-0s7ok4uw	1807	3	amount	amount	NN
cord-001835-0s7ok4uw	1807	4	of	of	IN
cord-001835-0s7ok4uw	1807	5	activation	activation	NN
cord-001835-0s7ok4uw	1807	6	volume	volume	NN
cord-001835-0s7ok4uw	1807	7	data	datum	NNS
cord-001835-0s7ok4uw	1807	8	in	in	IN
cord-001835-0s7ok4uw	1807	9	the	the	DT
cord-001835-0s7ok4uw	1807	10	literature	literature	NN
cord-001835-0s7ok4uw	1807	11	has	have	VBZ
cord-001835-0s7ok4uw	1807	12	gone	go	VBN
cord-001835-0s7ok4uw	1807	13	largely	largely	RB
cord-001835-0s7ok4uw	1807	14	uninterpreted	uninterpreted	JJ
cord-001835-0s7ok4uw	1807	15	at	at	IN
cord-001835-0s7ok4uw	1807	16	the	the	DT
cord-001835-0s7ok4uw	1807	17	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	1807	18	level	level	NN
cord-001835-0s7ok4uw	1807	19	.	.	.
cord-001835-0s7ok4uw	1808	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1808	2	propose	propose	VBP
cord-001835-0s7ok4uw	1808	3	to	to	TO
cord-001835-0s7ok4uw	1808	4	utilize	utilize	VB
cord-001835-0s7ok4uw	1808	5	this	this	DT
cord-001835-0s7ok4uw	1808	6	data	datum	NNS
cord-001835-0s7ok4uw	1808	7	in	in	IN
cord-001835-0s7ok4uw	1808	8	conjunction	conjunction	NN
cord-001835-0s7ok4uw	1808	9	with	with	IN
cord-001835-0s7ok4uw	1808	10	MD	MD	NNP
cord-001835-0s7ok4uw	1808	11	-	-	HYPH
cord-001835-0s7ok4uw	1808	12	calculated	calculate	VBN
cord-001835-0s7ok4uw	1808	13	volumetric	volumetric	JJ
cord-001835-0s7ok4uw	1808	14	properties	property	NNS
cord-001835-0s7ok4uw	1808	15	to	to	TO
cord-001835-0s7ok4uw	1808	16	identify	identify	VB
cord-001835-0s7ok4uw	1808	17	the	the	DT
cord-001835-0s7ok4uw	1808	18	TSE	TSE	NNP
cord-001835-0s7ok4uw	1808	19	for	for	IN
cord-001835-0s7ok4uw	1808	20	protein	protein	NN
cord-001835-0s7ok4uw	1808	21	folding	folding	NN
cord-001835-0s7ok4uw	1808	22	.	.	.
cord-001835-0s7ok4uw	1809	1	The	the	DT
cord-001835-0s7ok4uw	1809	2	effect	effect	NN
cord-001835-0s7ok4uw	1809	3	of	of	IN
cord-001835-0s7ok4uw	1809	4	pressure	pressure	NN
cord-001835-0s7ok4uw	1809	5	on	on	IN
cord-001835-0s7ok4uw	1809	6	reaction	reaction	NN
cord-001835-0s7ok4uw	1809	7	rates	rate	NNS
cord-001835-0s7ok4uw	1809	8	is	be	VBZ
cord-001835-0s7ok4uw	1809	9	expressed	express	VBN
cord-001835-0s7ok4uw	1809	10	in	in	IN
cord-001835-0s7ok4uw	1809	11	terms	term	NNS
cord-001835-0s7ok4uw	1809	12	of	of	IN
cord-001835-0s7ok4uw	1809	13	logarithmic	logarithmic	JJ
cord-001835-0s7ok4uw	1809	14	pressure	pressure	NN
cord-001835-0s7ok4uw	1809	15	derivatives	derivative	NNS
cord-001835-0s7ok4uw	1809	16	,	,	,
cord-001835-0s7ok4uw	1809	17	known	know	VBN
cord-001835-0s7ok4uw	1809	18	as	as	IN
cord-001835-0s7ok4uw	1809	19	activation	activation	NN
cord-001835-0s7ok4uw	1809	20	volumes	volume	NNS
cord-001835-0s7ok4uw	1809	21	.	.	.
cord-001835-0s7ok4uw	1810	1	According	accord	VBG
cord-001835-0s7ok4uw	1810	2	to	to	IN
cord-001835-0s7ok4uw	1810	3	TS	TS	NNP
cord-001835-0s7ok4uw	1810	4	theory	theory	NN
cord-001835-0s7ok4uw	1810	5	,	,	,
cord-001835-0s7ok4uw	1810	6	activation	activation	NN
cord-001835-0s7ok4uw	1810	7	volumes	volume	NNS
cord-001835-0s7ok4uw	1810	8	can	can	MD
cord-001835-0s7ok4uw	1810	9	be	be	VB
cord-001835-0s7ok4uw	1810	10	identified	identify	VBN
cord-001835-0s7ok4uw	1810	11	as	as	IN
cord-001835-0s7ok4uw	1810	12	the	the	DT
cord-001835-0s7ok4uw	1810	13	difference	difference	NN
cord-001835-0s7ok4uw	1810	14	in	in	IN
cord-001835-0s7ok4uw	1810	15	volume	volume	NN
cord-001835-0s7ok4uw	1810	16	between	between	IN
cord-001835-0s7ok4uw	1810	17	the	the	DT
cord-001835-0s7ok4uw	1810	18	TS	ts	NN
cord-001835-0s7ok4uw	1810	19	and	and	CC
cord-001835-0s7ok4uw	1810	20	reactant	reactant	NN
cord-001835-0s7ok4uw	1810	21	species	specie	NNS
cord-001835-0s7ok4uw	1810	22	:	:	:
cord-001835-0s7ok4uw	1810	23	Activation	activation	NN
cord-001835-0s7ok4uw	1810	24	volumes	volume	NNS
cord-001835-0s7ok4uw	1810	25	DV	DV	NNP
cord-001835-0s7ok4uw	1810	26	‡	‡	NNP
cord-001835-0s7ok4uw	1810	27	have	have	VBP
cord-001835-0s7ok4uw	1810	28	been	be	VBN
cord-001835-0s7ok4uw	1810	29	experimentally	experimentally	RB
cord-001835-0s7ok4uw	1810	30	determined	determine	VBN
cord-001835-0s7ok4uw	1810	31	for	for	IN
cord-001835-0s7ok4uw	1810	32	the	the	DT
cord-001835-0s7ok4uw	1810	33	folding	folding	NN
cord-001835-0s7ok4uw	1810	34	of	of	IN
cord-001835-0s7ok4uw	1810	35	several	several	JJ
cord-001835-0s7ok4uw	1810	36	proteins	protein	NNS
cord-001835-0s7ok4uw	1810	37	.	.	.
cord-001835-0s7ok4uw	1811	1	The	the	DT
cord-001835-0s7ok4uw	1811	2	concept	concept	NN
cord-001835-0s7ok4uw	1811	3	of	of	IN
cord-001835-0s7ok4uw	1811	4	activation	activation	NN
cord-001835-0s7ok4uw	1811	5	volume	volume	NN
cord-001835-0s7ok4uw	1811	6	can	can	MD
cord-001835-0s7ok4uw	1811	7	be	be	VB
cord-001835-0s7ok4uw	1811	8	extended	extend	VBN
cord-001835-0s7ok4uw	1811	9	to	to	IN
cord-001835-0s7ok4uw	1811	10	that	that	DT
cord-001835-0s7ok4uw	1811	11	of	of	IN
cord-001835-0s7ok4uw	1811	12	a	a	DT
cord-001835-0s7ok4uw	1811	13	volume	volume	NN
cord-001835-0s7ok4uw	1811	14	profile	profile	NN
cord-001835-0s7ok4uw	1811	15	,	,	,
cord-001835-0s7ok4uw	1811	16	DV(y	DV(y	NNP
cord-001835-0s7ok4uw	1811	17	)	)	-RRB-
cord-001835-0s7ok4uw	1811	18	,	,	,
cord-001835-0s7ok4uw	1811	19	which	which	WDT
cord-001835-0s7ok4uw	1811	20	describes	describe	VBZ
cord-001835-0s7ok4uw	1811	21	how	how	WRB
cord-001835-0s7ok4uw	1811	22	the	the	DT
cord-001835-0s7ok4uw	1811	23	volume	volume	NN
cord-001835-0s7ok4uw	1811	24	of	of	IN
cord-001835-0s7ok4uw	1811	25	a	a	DT
cord-001835-0s7ok4uw	1811	26	system	system	NN
cord-001835-0s7ok4uw	1811	27	changes	change	VBZ
cord-001835-0s7ok4uw	1811	28	along	along	IN
cord-001835-0s7ok4uw	1811	29	reaction	reaction	NN
cord-001835-0s7ok4uw	1811	30	coordinate	coordinate	NNP
cord-001835-0s7ok4uw	1811	31	y.	y.	NN
cord-001835-0s7ok4uw	1812	1	If	if	IN
cord-001835-0s7ok4uw	1812	2	the	the	DT
cord-001835-0s7ok4uw	1812	3	position	position	NN
cord-001835-0s7ok4uw	1812	4	y	y	NNP
cord-001835-0s7ok4uw	1812	5	‡	‡	NNP
cord-001835-0s7ok4uw	1812	6	of	of	IN
cord-001835-0s7ok4uw	1812	7	the	the	DT
cord-001835-0s7ok4uw	1812	8	TS	TS	NNP
cord-001835-0s7ok4uw	1812	9	along	along	IN
cord-001835-0s7ok4uw	1812	10	the	the	DT
cord-001835-0s7ok4uw	1812	11	reaction	reaction	NN
cord-001835-0s7ok4uw	1812	12	coordinate	coordinate	NN
cord-001835-0s7ok4uw	1812	13	is	be	VBZ
cord-001835-0s7ok4uw	1812	14	unknown	unknown	JJ
cord-001835-0s7ok4uw	1812	15	,	,	,
cord-001835-0s7ok4uw	1812	16	it	-PRON-	PRP
cord-001835-0s7ok4uw	1812	17	can	can	MD
cord-001835-0s7ok4uw	1812	18	be	be	VB
cord-001835-0s7ok4uw	1812	19	found	find	VBN
cord-001835-0s7ok4uw	1812	20	by	by	IN
cord-001835-0s7ok4uw	1812	21	locating	locate	VBG
cord-001835-0s7ok4uw	1812	22	DV	DV	NNP
cord-001835-0s7ok4uw	1812	23	‡	‡	NNP
cord-001835-0s7ok4uw	1812	24	on	on	IN
cord-001835-0s7ok4uw	1812	25	the	the	DT
cord-001835-0s7ok4uw	1812	26	volume	volume	NN
cord-001835-0s7ok4uw	1812	27	profile	profile	NN
cord-001835-0s7ok4uw	1812	28	:	:	:
cord-001835-0s7ok4uw	1812	29	Such	such	JJ
cord-001835-0s7ok4uw	1812	30	volume	volume	NN
cord-001835-0s7ok4uw	1812	31	profiles	profile	NNS
cord-001835-0s7ok4uw	1812	32	can	can	MD
cord-001835-0s7ok4uw	1812	33	be	be	VB
cord-001835-0s7ok4uw	1812	34	built	build	VBN
cord-001835-0s7ok4uw	1812	35	using	use	VBG
cord-001835-0s7ok4uw	1812	36	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1812	37	recently	recently	RB
cord-001835-0s7ok4uw	1812	38	developed	develop	VBN
cord-001835-0s7ok4uw	1812	39	MD	MD	NNP
cord-001835-0s7ok4uw	1812	40	-	-	HYPH
cord-001835-0s7ok4uw	1812	41	based	base	VBN
cord-001835-0s7ok4uw	1812	42	displacement	displacement	NN
cord-001835-0s7ok4uw	1812	43	volume	volume	NN
cord-001835-0s7ok4uw	1812	44	method	method	NN
cord-001835-0s7ok4uw	1812	45	.	.	.
cord-001835-0s7ok4uw	1813	1	*	*	NFP
cord-001835-0s7ok4uw	1813	2	Using	use	VBG
cord-001835-0s7ok4uw	1813	3	this	this	DT
cord-001835-0s7ok4uw	1813	4	method	method	NN
cord-001835-0s7ok4uw	1813	5	,	,	,
cord-001835-0s7ok4uw	1813	6	volumes	volume	NNS
cord-001835-0s7ok4uw	1813	7	of	of	IN
cord-001835-0s7ok4uw	1813	8	single	single	JJ
cord-001835-0s7ok4uw	1813	9	molecules	molecule	NNS
cord-001835-0s7ok4uw	1813	10	can	can	MD
cord-001835-0s7ok4uw	1813	11	be	be	VB
cord-001835-0s7ok4uw	1813	12	calculated	calculate	VBN
cord-001835-0s7ok4uw	1813	13	by	by	IN
cord-001835-0s7ok4uw	1813	14	taking	take	VBG
cord-001835-0s7ok4uw	1813	15	the	the	DT
cord-001835-0s7ok4uw	1813	16	difference	difference	NN
cord-001835-0s7ok4uw	1813	17	between	between	IN
cord-001835-0s7ok4uw	1813	18	the	the	DT
cord-001835-0s7ok4uw	1813	19	volume	volume	NN
cord-001835-0s7ok4uw	1813	20	of	of	IN
cord-001835-0s7ok4uw	1813	21	pure	pure	JJ
cord-001835-0s7ok4uw	1813	22	solvent	solvent	NN
cord-001835-0s7ok4uw	1813	23	and	and	CC
cord-001835-0s7ok4uw	1813	24	solvent	solvent	NN
cord-001835-0s7ok4uw	1813	25	containing	contain	VBG
cord-001835-0s7ok4uw	1813	26	the	the	DT
cord-001835-0s7ok4uw	1813	27	desired	desire	VBN
cord-001835-0s7ok4uw	1813	28	solute	solute	NN
cord-001835-0s7ok4uw	1813	29	.	.	.
cord-001835-0s7ok4uw	1814	1	This	this	DT
cord-001835-0s7ok4uw	1814	2	method	method	NN
cord-001835-0s7ok4uw	1814	3	takes	take	VBZ
cord-001835-0s7ok4uw	1814	4	into	into	IN
cord-001835-0s7ok4uw	1814	5	account	account	NN
cord-001835-0s7ok4uw	1814	6	the	the	DT
cord-001835-0s7ok4uw	1814	7	strength	strength	NN
cord-001835-0s7ok4uw	1814	8	and	and	CC
cord-001835-0s7ok4uw	1814	9	type	type	NN
cord-001835-0s7ok4uw	1814	10	of	of	IN
cord-001835-0s7ok4uw	1814	11	solvent	solvent	NN
cord-001835-0s7ok4uw	1814	12	-	-	HYPH
cord-001835-0s7ok4uw	1814	13	solute	solute	NN
cord-001835-0s7ok4uw	1814	14	interactions	interaction	NNS
cord-001835-0s7ok4uw	1814	15	as	as	RB
cord-001835-0s7ok4uw	1814	16	well	well	RB
cord-001835-0s7ok4uw	1814	17	as	as	IN
cord-001835-0s7ok4uw	1814	18	the	the	DT
cord-001835-0s7ok4uw	1814	19	geometrical	geometrical	JJ
cord-001835-0s7ok4uw	1814	20	configuration	configuration	NN
cord-001835-0s7ok4uw	1814	21	of	of	IN
cord-001835-0s7ok4uw	1814	22	the	the	DT
cord-001835-0s7ok4uw	1814	23	solute	solute	NN
cord-001835-0s7ok4uw	1814	24	.	.	.
cord-001835-0s7ok4uw	1815	1	In	in	IN
cord-001835-0s7ok4uw	1815	2	this	this	DT
cord-001835-0s7ok4uw	1815	3	work	work	NN
cord-001835-0s7ok4uw	1815	4	,	,	,
cord-001835-0s7ok4uw	1815	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1815	6	present	present	VBP
cord-001835-0s7ok4uw	1815	7	the	the	DT
cord-001835-0s7ok4uw	1815	8	successful	successful	JJ
cord-001835-0s7ok4uw	1815	9	application	application	NN
cord-001835-0s7ok4uw	1815	10	of	of	IN
cord-001835-0s7ok4uw	1815	11	this	this	DT
cord-001835-0s7ok4uw	1815	12	method	method	NN
cord-001835-0s7ok4uw	1815	13	to	to	IN
cord-001835-0s7ok4uw	1815	14	several	several	JJ
cord-001835-0s7ok4uw	1815	15	conformationally	conformationally	RB
cord-001835-0s7ok4uw	1815	16	flexible	flexible	JJ
cord-001835-0s7ok4uw	1815	17	systems	system	NNS
cord-001835-0s7ok4uw	1815	18	.	.	.
cord-001835-0s7ok4uw	1815	19	 	 	_SP
cord-001835-0s7ok4uw	1816	1	Structure	structure	NN
cord-001835-0s7ok4uw	1816	2	of	of	IN
cord-001835-0s7ok4uw	1816	3	the	the	DT
cord-001835-0s7ok4uw	1816	4	P15PAF	P15PAF	NNP
cord-001835-0s7ok4uw	1816	5	/	/	SYM
cord-001835-0s7ok4uw	1816	6	PCNA	PCNA	NNP
cord-001835-0s7ok4uw	1816	7	complex	complex	NN
cord-001835-0s7ok4uw	1816	8	and	and	CC
cord-001835-0s7ok4uw	1816	9	implications	implication	NNS
cord-001835-0s7ok4uw	1816	10	for	for	IN
cord-001835-0s7ok4uw	1816	11	clamp	clamp	NN
cord-001835-0s7ok4uw	1816	12	sliding	slide	VBG
cord-001835-0s7ok4uw	1816	13	on	on	IN
cord-001835-0s7ok4uw	1816	14	the	the	DT
cord-001835-0s7ok4uw	1816	15	DNA	dna	NN
cord-001835-0s7ok4uw	1816	16	during	during	IN
cord-001835-0s7ok4uw	1816	17	replication	replication	NN
cord-001835-0s7ok4uw	1816	18	and	and	CC
cord-001835-0s7ok4uw	1816	19	repair	repair	NN
cord-001835-0s7ok4uw	1816	20	to	to	IN
cord-001835-0s7ok4uw	1816	21	the	the	DT
cord-001835-0s7ok4uw	1816	22	canonical	canonical	JJ
cord-001835-0s7ok4uw	1816	23	PIP	PIP	NNP
cord-001835-0s7ok4uw	1816	24	-	-	HYPH
cord-001835-0s7ok4uw	1816	25	box	box	NN
cord-001835-0s7ok4uw	1816	26	binding	binding	NN
cord-001835-0s7ok4uw	1816	27	groove	groove	NN
cord-001835-0s7ok4uw	1816	28	on	on	IN
cord-001835-0s7ok4uw	1816	29	the	the	DT
cord-001835-0s7ok4uw	1816	30	PCNA	PCNA	NNP
cord-001835-0s7ok4uw	1816	31	front	front	NN
cord-001835-0s7ok4uw	1816	32	face	face	NN
cord-001835-0s7ok4uw	1816	33	.	.	.
cord-001835-0s7ok4uw	1817	1	In	in	IN
cord-001835-0s7ok4uw	1817	2	contrast	contrast	NN
cord-001835-0s7ok4uw	1817	3	to	to	IN
cord-001835-0s7ok4uw	1817	4	other	other	JJ
cord-001835-0s7ok4uw	1817	5	PCNA	PCNA	NNS
cord-001835-0s7ok4uw	1817	6	interacting	interact	VBG
cord-001835-0s7ok4uw	1817	7	proteins	protein	NNS
cord-001835-0s7ok4uw	1817	8	,	,	,
cord-001835-0s7ok4uw	1817	9	however	however	RB
cord-001835-0s7ok4uw	1817	10	,	,	,
cord-001835-0s7ok4uw	1817	11	p15PAF	p15PAF	NNP
cord-001835-0s7ok4uw	1817	12	also	also	RB
cord-001835-0s7ok4uw	1817	13	contacts	contact	VBZ
cord-001835-0s7ok4uw	1817	14	the	the	DT
cord-001835-0s7ok4uw	1817	15	inside	inside	NN
cord-001835-0s7ok4uw	1817	16	of	of	IN
cord-001835-0s7ok4uw	1817	17	,	,	,
cord-001835-0s7ok4uw	1817	18	and	and	CC
cord-001835-0s7ok4uw	1817	19	passes	pass	VBZ
cord-001835-0s7ok4uw	1817	20	through	through	RP
cord-001835-0s7ok4uw	1817	21	,	,	,
cord-001835-0s7ok4uw	1817	22	the	the	DT
cord-001835-0s7ok4uw	1817	23	PCNA	PCNA	NNP
cord-001835-0s7ok4uw	1817	24	ring	ring	NN
cord-001835-0s7ok4uw	1817	25	.	.	.
cord-001835-0s7ok4uw	1818	1	The	the	DT
cord-001835-0s7ok4uw	1818	2	mostly	mostly	RB
cord-001835-0s7ok4uw	1818	3	disordered	disordered	JJ
cord-001835-0s7ok4uw	1818	4	p15PAF	p15paf	NN
cord-001835-0s7ok4uw	1818	5	chain	chain	NN
cord-001835-0s7ok4uw	1818	6	termini	terminus	NNS
cord-001835-0s7ok4uw	1818	7	thus	thus	RB
cord-001835-0s7ok4uw	1818	8	emerge	emerge	VBP
cord-001835-0s7ok4uw	1818	9	at	at	IN
cord-001835-0s7ok4uw	1818	10	opposite	opposite	JJ
cord-001835-0s7ok4uw	1818	11	faces	face	NNS
cord-001835-0s7ok4uw	1818	12	of	of	IN
cord-001835-0s7ok4uw	1818	13	the	the	DT
cord-001835-0s7ok4uw	1818	14	ring	ring	NN
cord-001835-0s7ok4uw	1818	15	,	,	,
cord-001835-0s7ok4uw	1818	16	but	but	CC
cord-001835-0s7ok4uw	1818	17	remain	remain	VBP
cord-001835-0s7ok4uw	1818	18	protected	protect	VBN
cord-001835-0s7ok4uw	1818	19	from	from	IN
cord-001835-0s7ok4uw	1818	20	degradation	degradation	NN
cord-001835-0s7ok4uw	1818	21	by	by	IN
cord-001835-0s7ok4uw	1818	22	the	the	DT
cord-001835-0s7ok4uw	1818	23	20S	20S	NNP
cord-001835-0s7ok4uw	1818	24	core	core	NN
cord-001835-0s7ok4uw	1818	25	proteasome	proteasome	NN
cord-001835-0s7ok4uw	1818	26	.	.	.
cord-001835-0s7ok4uw	1819	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1819	2	also	also	RB
cord-001835-0s7ok4uw	1819	3	unveil	unveil	VBP
cord-001835-0s7ok4uw	1819	4	a	a	DT
cord-001835-0s7ok4uw	1819	5	novel	novel	JJ
cord-001835-0s7ok4uw	1819	6	DNA	dna	NN
cord-001835-0s7ok4uw	1819	7	binding	binding	NN
cord-001835-0s7ok4uw	1819	8	activity	activity	NN
cord-001835-0s7ok4uw	1819	9	of	of	IN
cord-001835-0s7ok4uw	1819	10	p15PAF	p15paf	NN
cord-001835-0s7ok4uw	1819	11	,	,	,
cord-001835-0s7ok4uw	1819	12	both	both	CC
cord-001835-0s7ok4uw	1819	13	free	free	JJ
cord-001835-0s7ok4uw	1819	14	and	and	CC
cord-001835-0s7ok4uw	1819	15	bound	bind	VBN
cord-001835-0s7ok4uw	1819	16	to	to	IN
cord-001835-0s7ok4uw	1819	17	PCNA	PCNA	NNP
cord-001835-0s7ok4uw	1819	18	,	,	,
cord-001835-0s7ok4uw	1819	19	which	which	WDT
cord-001835-0s7ok4uw	1819	20	is	be	VBZ
cord-001835-0s7ok4uw	1819	21	mainly	mainly	RB
cord-001835-0s7ok4uw	1819	22	mediated	mediate	VBN
cord-001835-0s7ok4uw	1819	23	by	by	IN
cord-001835-0s7ok4uw	1819	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1819	25	conserved	conserved	JJ
cord-001835-0s7ok4uw	1819	26	histone	histone	NN
cord-001835-0s7ok4uw	1819	27	-	-	HYPH
cord-001835-0s7ok4uw	1819	28	like	like	JJ
cord-001835-0s7ok4uw	1819	29	N	n	CD
cord-001835-0s7ok4uw	1819	30	-	-	HYPH
cord-001835-0s7ok4uw	1819	31	terminal	terminal	NN
cord-001835-0s7ok4uw	1819	32	tail	tail	NN
cord-001835-0s7ok4uw	1819	33	.	.	.
cord-001835-0s7ok4uw	1820	1	Molecular	molecular	JJ
cord-001835-0s7ok4uw	1820	2	modeling	modeling	NN
cord-001835-0s7ok4uw	1820	3	shows	show	VBZ
cord-001835-0s7ok4uw	1820	4	that	that	IN
cord-001835-0s7ok4uw	1820	5	a	a	DT
cord-001835-0s7ok4uw	1820	6	ternary	ternary	JJ
cord-001835-0s7ok4uw	1820	7	complex	complex	NN
cord-001835-0s7ok4uw	1820	8	with	with	IN
cord-001835-0s7ok4uw	1820	9	a	a	DT
cord-001835-0s7ok4uw	1820	10	duplex	duplex	JJ
cord-001835-0s7ok4uw	1820	11	DNA	dna	NN
cord-001835-0s7ok4uw	1820	12	inside	inside	IN
cord-001835-0s7ok4uw	1820	13	the	the	DT
cord-001835-0s7ok4uw	1820	14	PCNA	PCNA	NNP
cord-001835-0s7ok4uw	1820	15	ring	ring	NN
cord-001835-0s7ok4uw	1820	16	is	be	VBZ
cord-001835-0s7ok4uw	1820	17	energetically	energetically	RB
cord-001835-0s7ok4uw	1820	18	feasible	feasible	JJ
cord-001835-0s7ok4uw	1820	19	and	and	CC
cord-001835-0s7ok4uw	1820	20	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1820	21	electron	electron	NN
cord-001835-0s7ok4uw	1820	22	micrographs	micrograph	NNS
cord-001835-0s7ok4uw	1820	23	show	show	VBP
cord-001835-0s7ok4uw	1820	24	increased	increase	VBN
cord-001835-0s7ok4uw	1820	25	density	density	NN
cord-001835-0s7ok4uw	1820	26	inside	inside	IN
cord-001835-0s7ok4uw	1820	27	the	the	DT
cord-001835-0s7ok4uw	1820	28	ring	ring	NN
cord-001835-0s7ok4uw	1820	29	.	.	.
cord-001835-0s7ok4uw	1821	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1821	2	propose	propose	VBP
cord-001835-0s7ok4uw	1821	3	that	that	IN
cord-001835-0s7ok4uw	1821	4	p15PAF	p15paf	NN
cord-001835-0s7ok4uw	1821	5	acts	act	VBZ
cord-001835-0s7ok4uw	1821	6	as	as	IN
cord-001835-0s7ok4uw	1821	7	a	a	DT
cord-001835-0s7ok4uw	1821	8	flexible	flexible	JJ
cord-001835-0s7ok4uw	1821	9	drag	drag	NN
cord-001835-0s7ok4uw	1821	10	that	that	WDT
cord-001835-0s7ok4uw	1821	11	regulates	regulate	VBZ
cord-001835-0s7ok4uw	1821	12	PCNA	PCNA	NNS
cord-001835-0s7ok4uw	1821	13	sliding	slide	VBG
cord-001835-0s7ok4uw	1821	14	along	along	IN
cord-001835-0s7ok4uw	1821	15	the	the	DT
cord-001835-0s7ok4uw	1821	16	DNA	dna	NN
cord-001835-0s7ok4uw	1821	17	,	,	,
cord-001835-0s7ok4uw	1821	18	and	and	CC
cord-001835-0s7ok4uw	1821	19	may	may	MD
cord-001835-0s7ok4uw	1821	20	facilitate	facilitate	VB
cord-001835-0s7ok4uw	1821	21	the	the	DT
cord-001835-0s7ok4uw	1821	22	switch	switch	NN
cord-001835-0s7ok4uw	1821	23	from	from	IN
cord-001835-0s7ok4uw	1821	24	replicative	replicative	JJ
cord-001835-0s7ok4uw	1821	25	to	to	IN
cord-001835-0s7ok4uw	1821	26	translesion	translesion	NN
cord-001835-0s7ok4uw	1821	27	synthesis	synthesis	NN
cord-001835-0s7ok4uw	1821	28	polymerase	polymerase	NN
cord-001835-0s7ok4uw	1821	29	binding	bind	VBG
cord-001835-0s7ok4uw	1821	30	upon	upon	IN
cord-001835-0s7ok4uw	1821	31	DNA	dna	NN
cord-001835-0s7ok4uw	1821	32	damage	damage	NN
cord-001835-0s7ok4uw	1821	33	.	.	.
cord-001835-0s7ok4uw	1822	1	Acknowledgements	acknowledgement	NNS
cord-001835-0s7ok4uw	1822	2	:	:	:
cord-001835-0s7ok4uw	1823	1	This	this	DT
cord-001835-0s7ok4uw	1823	2	work	work	NN
cord-001835-0s7ok4uw	1823	3	has	have	VBZ
cord-001835-0s7ok4uw	1823	4	been	be	VBN
cord-001835-0s7ok4uw	1823	5	mainly	mainly	RB
cord-001835-0s7ok4uw	1823	6	sponsored	sponsor	VBN
cord-001835-0s7ok4uw	1823	7	by	by	IN
cord-001835-0s7ok4uw	1823	8	MINECO	MINECO	NNP
cord-001835-0s7ok4uw	1823	9	grant	grant	VBP
cord-001835-0s7ok4uw	1823	10	CTQ2011	CTQ2011	NNP
cord-001835-0s7ok4uw	1823	11	-	-	HYPH
cord-001835-0s7ok4uw	1823	12	28680	28680	CD
cord-001835-0s7ok4uw	1823	13	and	and	CC
cord-001835-0s7ok4uw	1823	14	Juan	Juan	NNP
cord-001835-0s7ok4uw	1823	15	de	de	NNP
cord-001835-0s7ok4uw	1823	16	la	la	NNP
cord-001835-0s7ok4uw	1823	17	Cierva-2010	Cierva-2010	NNP
cord-001835-0s7ok4uw	1823	18	contract	contract	NN
cord-001835-0s7ok4uw	1823	19	to	to	IN
cord-001835-0s7ok4uw	1823	20	Alfredo	Alfredo	NNP
cord-001835-0s7ok4uw	1823	21	De	De	NNP
cord-001835-0s7ok4uw	1823	22	Biasio	Biasio	NNP
cord-001835-0s7ok4uw	1823	23	.	.	.
cord-001835-0s7ok4uw	1824	1	Metabolic	metabolic	JJ
cord-001835-0s7ok4uw	1824	2	syndrome	syndrome	NN
cord-001835-0s7ok4uw	1824	3	(	(	-LRB-
cord-001835-0s7ok4uw	1824	4	MetS	MetS	NNP
cord-001835-0s7ok4uw	1824	5	)	)	-RRB-
cord-001835-0s7ok4uw	1824	6	is	be	VBZ
cord-001835-0s7ok4uw	1824	7	one	one	CD
cord-001835-0s7ok4uw	1824	8	of	of	IN
cord-001835-0s7ok4uw	1824	9	the	the	DT
cord-001835-0s7ok4uw	1824	10	leading	lead	VBG
cord-001835-0s7ok4uw	1824	11	causes	cause	NNS
cord-001835-0s7ok4uw	1824	12	of	of	IN
cord-001835-0s7ok4uw	1824	13	the	the	DT
cord-001835-0s7ok4uw	1824	14	death	death	NN
cord-001835-0s7ok4uw	1824	15	worldwide	worldwide	RB
cord-001835-0s7ok4uw	1824	16	;	;	:
cord-001835-0s7ok4uw	1824	17	however	however	RB
cord-001835-0s7ok4uw	1824	18	,	,	,
cord-001835-0s7ok4uw	1824	19	exact	exact	JJ
cord-001835-0s7ok4uw	1824	20	pathophysiological	pathophysiological	JJ
cord-001835-0s7ok4uw	1824	21	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1824	22	of	of	IN
cord-001835-0s7ok4uw	1824	23	MetS	met	NNS
cord-001835-0s7ok4uw	1824	24	remain	remain	VBP
cord-001835-0s7ok4uw	1824	25	largely	largely	RB
cord-001835-0s7ok4uw	1824	26	unknown	unknown	JJ
cord-001835-0s7ok4uw	1824	27	.	.	.
cord-001835-0s7ok4uw	1825	1	Growing	grow	VBG
cord-001835-0s7ok4uw	1825	2	evidence	evidence	NN
cord-001835-0s7ok4uw	1825	3	suggests	suggest	VBZ
cord-001835-0s7ok4uw	1825	4	that	that	IN
cord-001835-0s7ok4uw	1825	5	the	the	DT
cord-001835-0s7ok4uw	1825	6	increased	increase	VBN
cord-001835-0s7ok4uw	1825	7	availability	availability	NN
cord-001835-0s7ok4uw	1825	8	of	of	IN
cord-001835-0s7ok4uw	1825	9	glucocorticoids	glucocorticoid	NNS
cord-001835-0s7ok4uw	1825	10	at	at	IN
cord-001835-0s7ok4uw	1825	11	the	the	DT
cord-001835-0s7ok4uw	1825	12	tissue	tissue	NN
cord-001835-0s7ok4uw	1825	13	level	level	NN
cord-001835-0s7ok4uw	1825	14	play	play	VBP
cord-001835-0s7ok4uw	1825	15	an	an	DT
cord-001835-0s7ok4uw	1825	16	important	important	JJ
cord-001835-0s7ok4uw	1825	17	in	in	IN
cord-001835-0s7ok4uw	1825	18	MetS	MetS	NNP
cord-001835-0s7ok4uw	1825	19	development	development	NN
cord-001835-0s7ok4uw	1825	20	.	.	.
cord-001835-0s7ok4uw	1826	1	One	one	CD
cord-001835-0s7ok4uw	1826	2	of	of	IN
cord-001835-0s7ok4uw	1826	3	the	the	DT
cord-001835-0s7ok4uw	1826	4	major	major	JJ
cord-001835-0s7ok4uw	1826	5	determinants	determinant	NNS
cord-001835-0s7ok4uw	1826	6	of	of	IN
cord-001835-0s7ok4uw	1826	7	glucocorticoid	glucocorticoid	JJ
cord-001835-0s7ok4uw	1826	8	local	local	JJ
cord-001835-0s7ok4uw	1826	9	action	action	NN
cord-001835-0s7ok4uw	1826	10	seems	seem	VBZ
cord-001835-0s7ok4uw	1826	11	to	to	TO
cord-001835-0s7ok4uw	1826	12	be	be	VB
cord-001835-0s7ok4uw	1826	13	the	the	DT
cord-001835-0s7ok4uw	1826	14	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1826	15	11b	11b	NNS
cord-001835-0s7ok4uw	1826	16	-	-	:
cord-001835-0s7ok4uw	1826	17	hydroxysteroid	hydroxysteroid	NN
cord-001835-0s7ok4uw	1826	18	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	1826	19	1	1	CD
cord-001835-0s7ok4uw	1826	20	(	(	-LRB-
cord-001835-0s7ok4uw	1826	21	11b	11b	NNS
cord-001835-0s7ok4uw	1826	22	-	-	:
cord-001835-0s7ok4uw	1826	23	HSD1	HSD1	NNP
cord-001835-0s7ok4uw	1826	24	)	)	-RRB-
cord-001835-0s7ok4uw	1826	25	.	.	.
cord-001835-0s7ok4uw	1827	1	This	this	DT
cord-001835-0s7ok4uw	1827	2	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1827	3	is	be	VBZ
cord-001835-0s7ok4uw	1827	4	a	a	DT
cord-001835-0s7ok4uw	1827	5	well	well	RB
cord-001835-0s7ok4uw	1827	6	-	-	HYPH
cord-001835-0s7ok4uw	1827	7	known	know	VBN
cord-001835-0s7ok4uw	1827	8	member	member	NN
cord-001835-0s7ok4uw	1827	9	of	of	IN
cord-001835-0s7ok4uw	1827	10	the	the	DT
cord-001835-0s7ok4uw	1827	11	short	short	JJ
cord-001835-0s7ok4uw	1827	12	-	-	HYPH
cord-001835-0s7ok4uw	1827	13	chain	chain	NN
cord-001835-0s7ok4uw	1827	14	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	1827	15	/	/	SYM
cord-001835-0s7ok4uw	1827	16	reductase	reductase	NN
cord-001835-0s7ok4uw	1827	17	(	(	-LRB-
cord-001835-0s7ok4uw	1827	18	SDR	SDR	NNP
cord-001835-0s7ok4uw	1827	19	)	)	-RRB-
cord-001835-0s7ok4uw	1827	20	superfamily	superfamily	NN
cord-001835-0s7ok4uw	1827	21	.	.	.
cord-001835-0s7ok4uw	1828	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1828	2	is	be	VBZ
cord-001835-0s7ok4uw	1828	3	an	an	DT
cord-001835-0s7ok4uw	1828	4	important	important	JJ
cord-001835-0s7ok4uw	1828	5	carbonyl	carbonyl	NN
cord-001835-0s7ok4uw	1828	6	reducing	reduce	VBG
cord-001835-0s7ok4uw	1828	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1828	8	that	that	WDT
cord-001835-0s7ok4uw	1828	9	,	,	,
cord-001835-0s7ok4uw	1828	10	besides	besides	IN
cord-001835-0s7ok4uw	1828	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1828	12	role	role	NN
cord-001835-0s7ok4uw	1828	13	fine	fine	RB
cord-001835-0s7ok4uw	1828	14	-	-	HYPH
cord-001835-0s7ok4uw	1828	15	tuning	tuning	NN
cord-001835-0s7ok4uw	1828	16	of	of	IN
cord-001835-0s7ok4uw	1828	17	glucocorticoids	glucocorticoid	NNS
cord-001835-0s7ok4uw	1828	18	actions	action	NNS
cord-001835-0s7ok4uw	1828	19	,	,	,
cord-001835-0s7ok4uw	1828	20	is	be	VBZ
cord-001835-0s7ok4uw	1828	21	involved	involve	VBN
cord-001835-0s7ok4uw	1828	22	in	in	IN
cord-001835-0s7ok4uw	1828	23	the	the	DT
cord-001835-0s7ok4uw	1828	24	biotransformation	biotransformation	NN
cord-001835-0s7ok4uw	1828	25	of	of	IN
cord-001835-0s7ok4uw	1828	26	drugs	drug	NNS
cord-001835-0s7ok4uw	1828	27	and	and	CC
cord-001835-0s7ok4uw	1828	28	in	in	IN
cord-001835-0s7ok4uw	1828	29	the	the	DT
cord-001835-0s7ok4uw	1828	30	development	development	NN
cord-001835-0s7ok4uw	1828	31	of	of	IN
cord-001835-0s7ok4uw	1828	32	lung	lung	NN
cord-001835-0s7ok4uw	1828	33	cancer	cancer	NN
cord-001835-0s7ok4uw	1828	34	through	through	IN
cord-001835-0s7ok4uw	1828	35	metabolism	metabolism	NN
cord-001835-0s7ok4uw	1828	36	of	of	IN
cord-001835-0s7ok4uw	1828	37	the	the	DT
cord-001835-0s7ok4uw	1828	38	tobacco	tobacco	NN
cord-001835-0s7ok4uw	1828	39	specific	specific	JJ
cord-001835-0s7ok4uw	1828	40	carcinogen	carcinogen	NN
cord-001835-0s7ok4uw	1828	41	NNK	NNK	NNP
cord-001835-0s7ok4uw	1828	42	.	.	.
cord-001835-0s7ok4uw	1829	1	The	the	DT
cord-001835-0s7ok4uw	1829	2	phylogenetically	phylogenetically	RB
cord-001835-0s7ok4uw	1829	3	closest	close	JJS
cord-001835-0s7ok4uw	1829	4	relative	relative	NN
cord-001835-0s7ok4uw	1829	5	of	of	IN
cord-001835-0s7ok4uw	1829	6	11b	11b	NNS
cord-001835-0s7ok4uw	1829	7	-	-	:
cord-001835-0s7ok4uw	1829	8	HSD1	HSD1	NNP
cord-001835-0s7ok4uw	1829	9	is	be	VBZ
cord-001835-0s7ok4uw	1829	10	DHRS7	dhrs7	NN
cord-001835-0s7ok4uw	1829	11	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1829	12	from	from	IN
cord-001835-0s7ok4uw	1829	13	the	the	DT
cord-001835-0s7ok4uw	1829	14	same	same	JJ
cord-001835-0s7ok4uw	1829	15	superfamily	superfamily	NN
cord-001835-0s7ok4uw	1829	16	.	.	.
cord-001835-0s7ok4uw	1830	1	Unlike	unlike	IN
cord-001835-0s7ok4uw	1830	2	11b	11b	NNS
cord-001835-0s7ok4uw	1830	3	-	-	:
cord-001835-0s7ok4uw	1830	4	HSD1	HSD1	NNP
cord-001835-0s7ok4uw	1830	5	,	,	,
cord-001835-0s7ok4uw	1830	6	DHRS7	DHRS7	NNP
cord-001835-0s7ok4uw	1830	7	is	be	VBZ
cord-001835-0s7ok4uw	1830	8	poorly	poorly	RB
cord-001835-0s7ok4uw	1830	9	characterized	characterize	VBN
cord-001835-0s7ok4uw	1831	1	however	however	RB
cord-001835-0s7ok4uw	1831	2	it	-PRON-	PRP
cord-001835-0s7ok4uw	1831	3	can	can	MD
cord-001835-0s7ok4uw	1831	4	be	be	VB
cord-001835-0s7ok4uw	1831	5	supposed	suppose	VBN
cord-001835-0s7ok4uw	1831	6	at	at	IN
cord-001835-0s7ok4uw	1831	7	least	least	JJS
cord-001835-0s7ok4uw	1831	8	partially	partially	RB
cord-001835-0s7ok4uw	1831	9	overlapping	overlap	VBG
cord-001835-0s7ok4uw	1831	10	function	function	NN
cord-001835-0s7ok4uw	1831	11	to	to	IN
cord-001835-0s7ok4uw	1831	12	11b	11b	NNS
cord-001835-0s7ok4uw	1831	13	-	-	:
cord-001835-0s7ok4uw	1831	14	HSD1	HSD1	NNP
cord-001835-0s7ok4uw	1831	15	.	.	.
cord-001835-0s7ok4uw	1832	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	1832	2	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1832	3	possible	possible	JJ
cord-001835-0s7ok4uw	1832	4	association	association	NN
cord-001835-0s7ok4uw	1832	5	with	with	IN
cord-001835-0s7ok4uw	1832	6	similar	similar	JJ
cord-001835-0s7ok4uw	1832	7	pathological	pathological	JJ
cord-001835-0s7ok4uw	1832	8	conditions	condition	NNS
cord-001835-0s7ok4uw	1832	9	in	in	IN
cord-001835-0s7ok4uw	1832	10	human	human	NN
cord-001835-0s7ok4uw	1832	11	as	as	IN
cord-001835-0s7ok4uw	1832	12	11b	11b	NNS
cord-001835-0s7ok4uw	1832	13	-	-	:
cord-001835-0s7ok4uw	1832	14	HSD1	HSD1	NNP
cord-001835-0s7ok4uw	1832	15	has	have	VBZ
cord-001835-0s7ok4uw	1832	16	already	already	RB
cord-001835-0s7ok4uw	1832	17	been	be	VBN
cord-001835-0s7ok4uw	1832	18	indicated	indicate	VBN
cord-001835-0s7ok4uw	1832	19	by	by	IN
cord-001835-0s7ok4uw	1832	20	several	several	JJ
cord-001835-0s7ok4uw	1832	21	studies	study	NNS
cord-001835-0s7ok4uw	1832	22	.	.	.
cord-001835-0s7ok4uw	1833	1	The	the	DT
cord-001835-0s7ok4uw	1833	2	aim	aim	NN
cord-001835-0s7ok4uw	1833	3	of	of	IN
cord-001835-0s7ok4uw	1833	4	this	this	DT
cord-001835-0s7ok4uw	1833	5	study	study	NN
cord-001835-0s7ok4uw	1833	6	is	be	VBZ
cord-001835-0s7ok4uw	1833	7	the	the	DT
cord-001835-0s7ok4uw	1833	8	basic	basic	JJ
cord-001835-0s7ok4uw	1833	9	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	1833	10	characterization	characterization	NN
cord-001835-0s7ok4uw	1833	11	of	of	IN
cord-001835-0s7ok4uw	1833	12	DHRS7	DHRS7	NNP
cord-001835-0s7ok4uw	1833	13	.	.	.
cord-001835-0s7ok4uw	1834	1	The	the	DT
cord-001835-0s7ok4uw	1834	2	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1834	3	is	be	VBZ
cord-001835-0s7ok4uw	1834	4	a	a	DT
cord-001835-0s7ok4uw	1834	5	member	member	NN
cord-001835-0s7ok4uw	1834	6	of	of	IN
cord-001835-0s7ok4uw	1834	7	cluster	cluster	NN
cord-001835-0s7ok4uw	1834	8	3	3	CD
cord-001835-0s7ok4uw	1834	9	of	of	IN
cord-001835-0s7ok4uw	1834	10	"	"	``
cord-001835-0s7ok4uw	1834	11	classical	classical	JJ
cord-001835-0s7ok4uw	1834	12	"	"	''
cord-001835-0s7ok4uw	1834	13	SDR	SDR	NNP
cord-001835-0s7ok4uw	1834	14	;	;	,
cord-001835-0s7ok4uw	1834	15	such	such	JJ
cord-001835-0s7ok4uw	1834	16	members	member	NNS
cord-001835-0s7ok4uw	1834	17	are	be	VBP
cord-001835-0s7ok4uw	1834	18	considered	consider	VBN
cord-001835-0s7ok4uw	1834	19	to	to	TO
cord-001835-0s7ok4uw	1834	20	be	be	VB
cord-001835-0s7ok4uw	1834	21	retinoid	retinoid	NN
cord-001835-0s7ok4uw	1834	22	and	and	CC
cord-001835-0s7ok4uw	1834	23	steroid	steroid	NN
cord-001835-0s7ok4uw	1834	24	metabolizing	metabolize	VBG
cord-001835-0s7ok4uw	1834	25	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	1834	26	,	,	,
cord-001835-0s7ok4uw	1834	27	so	so	RB
cord-001835-0s7ok4uw	1834	28	characterization	characterization	NN
cord-001835-0s7ok4uw	1834	29	the	the	DT
cord-001835-0s7ok4uw	1834	30	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1834	31	was	be	VBD
cord-001835-0s7ok4uw	1834	32	based	base	VBN
cord-001835-0s7ok4uw	1834	33	on	on	IN
cord-001835-0s7ok4uw	1834	34	this	this	DT
cord-001835-0s7ok4uw	1834	35	assumption	assumption	NN
cord-001835-0s7ok4uw	1834	36	.	.	.
cord-001835-0s7ok4uw	1835	1	DHRS7	DHRS7	NNP
cord-001835-0s7ok4uw	1835	2	was	be	VBD
cord-001835-0s7ok4uw	1835	3	prepared	prepare	VBN
cord-001835-0s7ok4uw	1835	4	in	in	IN
cord-001835-0s7ok4uw	1835	5	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1835	6	form	form	NN
cord-001835-0s7ok4uw	1835	7	in	in	IN
cord-001835-0s7ok4uw	1835	8	the	the	DT
cord-001835-0s7ok4uw	1835	9	Sf9	sf9	NN
cord-001835-0s7ok4uw	1835	10	cell	cell	NN
cord-001835-0s7ok4uw	1835	11	line	line	NN
cord-001835-0s7ok4uw	1835	12	.	.	.
cord-001835-0s7ok4uw	1836	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1836	2	was	be	VBD
cord-001835-0s7ok4uw	1836	3	proved	prove	VBN
cord-001835-0s7ok4uw	1836	4	that	that	IN
cord-001835-0s7ok4uw	1836	5	this	this	DT
cord-001835-0s7ok4uw	1836	6	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	1836	7	is	be	VBZ
cord-001835-0s7ok4uw	1836	8	an	an	DT
cord-001835-0s7ok4uw	1836	9	integral	integral	JJ
cord-001835-0s7ok4uw	1836	10	membrane	membrane	NN
cord-001835-0s7ok4uw	1836	11	-	-	HYPH
cord-001835-0s7ok4uw	1836	12	bound	bind	VBN
cord-001835-0s7ok4uw	1836	13	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1836	14	localized	localize	VBN
cord-001835-0s7ok4uw	1836	15	in	in	IN
cord-001835-0s7ok4uw	1836	16	the	the	DT
cord-001835-0s7ok4uw	1836	17	endoplasmic	endoplasmic	NN
cord-001835-0s7ok4uw	1836	18	reticulum	reticulum	NN
cord-001835-0s7ok4uw	1836	19	with	with	IN
cord-001835-0s7ok4uw	1836	20	luminal	luminal	JJ
cord-001835-0s7ok4uw	1836	21	orientation	orientation	NN
cord-001835-0s7ok4uw	1836	22	,	,	,
cord-001835-0s7ok4uw	1836	23	similarly	similarly	RB
cord-001835-0s7ok4uw	1836	24	to	to	IN
cord-001835-0s7ok4uw	1836	25	11b	11b	NNS
cord-001835-0s7ok4uw	1836	26	-	-	:
cord-001835-0s7ok4uw	1836	27	HSD1	HSD1	NNP
cord-001835-0s7ok4uw	1836	28	.	.	.
cord-001835-0s7ok4uw	1837	1	Known	know	VBN
cord-001835-0s7ok4uw	1837	2	substrates	substrate	NNS
cord-001835-0s7ok4uw	1837	3	of	of	IN
cord-001835-0s7ok4uw	1837	4	11b	11b	NNS
cord-001835-0s7ok4uw	1837	5	-	-	:
cord-001835-0s7ok4uw	1837	6	HSD1	HSD1	NNP
cord-001835-0s7ok4uw	1837	7	and	and	CC
cord-001835-0s7ok4uw	1837	8	related	related	JJ
cord-001835-0s7ok4uw	1837	9	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	1837	10	were	be	VBD
cord-001835-0s7ok4uw	1837	11	tested	test	VBN
cord-001835-0s7ok4uw	1837	12	also	also	RB
cord-001835-0s7ok4uw	1837	13	as	as	IN
cord-001835-0s7ok4uw	1837	14	substrates	substrate	NNS
cord-001835-0s7ok4uw	1837	15	of	of	IN
cord-001835-0s7ok4uw	1837	16	DHRS7	DHRS7	NNP
cord-001835-0s7ok4uw	1837	17	.	.	.
cord-001835-0s7ok4uw	1838	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1838	2	was	be	VBD
cord-001835-0s7ok4uw	1838	3	proved	prove	VBN
cord-001835-0s7ok4uw	1838	4	that	that	IN
cord-001835-0s7ok4uw	1838	5	DHRS7	dhrs7	NN
cord-001835-0s7ok4uw	1838	6	is	be	VBZ
cord-001835-0s7ok4uw	1838	7	NADPH	nadph	NN
cord-001835-0s7ok4uw	1838	8	-	-	HYPH
cord-001835-0s7ok4uw	1838	9	dependent	dependent	JJ
cord-001835-0s7ok4uw	1838	10	reductase	reductase	NN
cord-001835-0s7ok4uw	1838	11	with	with	IN
cord-001835-0s7ok4uw	1838	12	important	important	JJ
cord-001835-0s7ok4uw	1838	13	substrates	substrate	NNS
cord-001835-0s7ok4uw	1838	14	as	as	IN
cord-001835-0s7ok4uw	1838	15	steroid	steroid	NN
cord-001835-0s7ok4uw	1838	16	hormones	hormone	NNS
cord-001835-0s7ok4uw	1838	17	cortisone	cortisone	NN
cord-001835-0s7ok4uw	1838	18	and	and	CC
cord-001835-0s7ok4uw	1838	19	androstene-3,14-dione	androstene-3,14-dione	NNP
cord-001835-0s7ok4uw	1838	20	,	,	,
cord-001835-0s7ok4uw	1838	21	all	all	RB
cord-001835-0s7ok4uw	1838	22	-	-	HYPH
cord-001835-0s7ok4uw	1838	23	transretinal	transretinal	JJ
cord-001835-0s7ok4uw	1838	24	and	and	CC
cord-001835-0s7ok4uw	1838	25	also	also	RB
cord-001835-0s7ok4uw	1838	26	xenobiotics	xenobiotic	NNS
cord-001835-0s7ok4uw	1838	27	as	as	IN
cord-001835-0s7ok4uw	1838	28	1,2-naphtoquinone	1,2-naphtoquinone	CD
cord-001835-0s7ok4uw	1838	29	or	or	CC
cord-001835-0s7ok4uw	1838	30	carcinogen	carcinogen	NN
cord-001835-0s7ok4uw	1838	31	NNK	NNK	NNP
cord-001835-0s7ok4uw	1838	32	at	at	IN
cord-001835-0s7ok4uw	1838	33	least	least	JJS
cord-001835-0s7ok4uw	1838	34	in	in	IN
cord-001835-0s7ok4uw	1838	35	vitro	vitro	FW
cord-001835-0s7ok4uw	1838	36	.	.	.
cord-001835-0s7ok4uw	1839	1	For	for	IN
cord-001835-0s7ok4uw	1839	2	better	well	JJR
cord-001835-0s7ok4uw	1839	3	understanding	understanding	NN
cord-001835-0s7ok4uw	1839	4	of	of	IN
cord-001835-0s7ok4uw	1839	5	the	the	DT
cord-001835-0s7ok4uw	1839	6	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1839	7	function	function	NN
cord-001835-0s7ok4uw	1839	8	of	of	IN
cord-001835-0s7ok4uw	1839	9	DHRS7	DHRS7	NNP
cord-001835-0s7ok4uw	1840	1	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1840	2	structural	structural	JJ
cord-001835-0s7ok4uw	1840	3	model	model	NN
cord-001835-0s7ok4uw	1840	4	was	be	VBD
cord-001835-0s7ok4uw	1840	5	prepared	prepared	JJ
cord-001835-0s7ok4uw	1840	6	and	and	CC
cord-001835-0s7ok4uw	1840	7	it	-PRON-	PRP
cord-001835-0s7ok4uw	1840	8	is	be	VBZ
cord-001835-0s7ok4uw	1840	9	used	use	VBN
cord-001835-0s7ok4uw	1840	10	also	also	RB
cord-001835-0s7ok4uw	1840	11	for	for	IN
cord-001835-0s7ok4uw	1840	12	the	the	DT
cord-001835-0s7ok4uw	1840	13	identification	identification	NN
cord-001835-0s7ok4uw	1840	14	of	of	IN
cord-001835-0s7ok4uw	1840	15	additional	additional	JJ
cord-001835-0s7ok4uw	1840	16	substrates	substrate	NNS
cord-001835-0s7ok4uw	1840	17	by	by	IN
cord-001835-0s7ok4uw	1840	18	ligand	ligand	NN
cord-001835-0s7ok4uw	1840	19	virtual	virtual	JJ
cord-001835-0s7ok4uw	1840	20	screening	screening	NN
cord-001835-0s7ok4uw	1840	21	.	.	.
cord-001835-0s7ok4uw	1841	1	DHRS7	DHRS7	NNP
cord-001835-0s7ok4uw	1841	2	enzyme	enzyme	NNP
cord-001835-0s7ok4uw	1841	3	is	be	VBZ
cord-001835-0s7ok4uw	1841	4	expressed	express	VBN
cord-001835-0s7ok4uw	1841	5	in	in	IN
cord-001835-0s7ok4uw	1841	6	several	several	JJ
cord-001835-0s7ok4uw	1841	7	human	human	JJ
cord-001835-0s7ok4uw	1841	8	tissues	tissue	NNS
cord-001835-0s7ok4uw	1841	9	as	as	IN
cord-001835-0s7ok4uw	1841	10	adrenals	adrenal	NNS
cord-001835-0s7ok4uw	1841	11	,	,	,
cord-001835-0s7ok4uw	1841	12	liver	liver	NN
cord-001835-0s7ok4uw	1841	13	,	,	,
cord-001835-0s7ok4uw	1841	14	prostate	prostate	NN
cord-001835-0s7ok4uw	1841	15	,	,	,
cord-001835-0s7ok4uw	1841	16	small	small	JJ
cord-001835-0s7ok4uw	1841	17	intestine	intestine	NN
cord-001835-0s7ok4uw	1841	18	and	and	CC
cord-001835-0s7ok4uw	1841	19	kidney	kidney	NN
cord-001835-0s7ok4uw	1841	20	.	.	.
cord-001835-0s7ok4uw	1842	1	These	these	DT
cord-001835-0s7ok4uw	1842	2	brand	brand	NN
cord-001835-0s7ok4uw	1842	3	new	new	JJ
cord-001835-0s7ok4uw	1842	4	initial	initial	JJ
cord-001835-0s7ok4uw	1842	5	results	result	NNS
cord-001835-0s7ok4uw	1842	6	point	point	NN
cord-001835-0s7ok4uw	1842	7	to	to	IN
cord-001835-0s7ok4uw	1842	8	the	the	DT
cord-001835-0s7ok4uw	1842	9	possible	possible	JJ
cord-001835-0s7ok4uw	1842	10	involvement	involvement	NN
cord-001835-0s7ok4uw	1842	11	of	of	IN
cord-001835-0s7ok4uw	1842	12	DHRS7	dhrs7	NN
cord-001835-0s7ok4uw	1842	13	in	in	IN
cord-001835-0s7ok4uw	1842	14	important	important	JJ
cord-001835-0s7ok4uw	1842	15	cellular	cellular	JJ
cord-001835-0s7ok4uw	1842	16	processes	process	NNS
cord-001835-0s7ok4uw	1842	17	that	that	WDT
cord-001835-0s7ok4uw	1842	18	deserve	deserve	VBP
cord-001835-0s7ok4uw	1842	19	further	further	JJ
cord-001835-0s7ok4uw	1842	20	investigation	investigation	NN
cord-001835-0s7ok4uw	1842	21	.	.	.
cord-001835-0s7ok4uw	1843	1	These	these	DT
cord-001835-0s7ok4uw	1843	2	results	result	NNS
cord-001835-0s7ok4uw	1843	3	will	will	MD
cord-001835-0s7ok4uw	1843	4	lay	lay	VB
cord-001835-0s7ok4uw	1843	5	the	the	DT
cord-001835-0s7ok4uw	1843	6	foundation	foundation	NN
cord-001835-0s7ok4uw	1843	7	for	for	IN
cord-001835-0s7ok4uw	1843	8	an	an	DT
cord-001835-0s7ok4uw	1843	9	understanding	understanding	NN
cord-001835-0s7ok4uw	1843	10	of	of	IN
cord-001835-0s7ok4uw	1843	11	DHRS7	dhrs7	NN
cord-001835-0s7ok4uw	1843	12	role	role	NN
cord-001835-0s7ok4uw	1843	13	in	in	IN
cord-001835-0s7ok4uw	1843	14	human	human	JJ
cord-001835-0s7ok4uw	1843	15	physiology	physiology	NN
cord-001835-0s7ok4uw	1843	16	resp	resp	NNP
cord-001835-0s7ok4uw	1843	17	.	.	.
cord-001835-0s7ok4uw	1844	1	pathophysiology	pathophysiology	NN
cord-001835-0s7ok4uw	1844	2	.	.	.
cord-001835-0s7ok4uw	1845	1	This	this	DT
cord-001835-0s7ok4uw	1845	2	project	project	NN
cord-001835-0s7ok4uw	1845	3	was	be	VBD
cord-001835-0s7ok4uw	1845	4	supported	support	VBN
cord-001835-0s7ok4uw	1845	5	by	by	IN
cord-001835-0s7ok4uw	1845	6	Grant	Grant	NNP
cord-001835-0s7ok4uw	1845	7	Agency	Agency	NNP
cord-001835-0s7ok4uw	1845	8	of	of	IN
cord-001835-0s7ok4uw	1845	9	Charles	Charles	NNP
cord-001835-0s7ok4uw	1845	10	University	University	NNP
cord-001835-0s7ok4uw	1845	11	(	(	-LRB-
cord-001835-0s7ok4uw	1845	12	677012	677012	CD
cord-001835-0s7ok4uw	1845	13	/	/	SYM
cord-001835-0s7ok4uw	1845	14	C/2012	C/2012	NNP
cord-001835-0s7ok4uw	1845	15	)	)	-RRB-
cord-001835-0s7ok4uw	1845	16	and	and	CC
cord-001835-0s7ok4uw	1845	17	UNCE	UNCE	NNP
cord-001835-0s7ok4uw	1845	18	204026/2012	204026/2012	CD
cord-001835-0s7ok4uw	1845	19	)	)	-RRB-
cord-001835-0s7ok4uw	1845	20	.	.	.
cord-001835-0s7ok4uw	1846	1	Structure	structure	NN
cord-001835-0s7ok4uw	1846	2	-	-	HYPH
cord-001835-0s7ok4uw	1846	3	based	base	VBN
cord-001835-0s7ok4uw	1846	4	functional	functional	JJ
cord-001835-0s7ok4uw	1846	5	identification	identification	NN
cord-001835-0s7ok4uw	1846	6	of	of	IN
cord-001835-0s7ok4uw	1846	7	Helicobacter	Helicobacter	NNP
cord-001835-0s7ok4uw	1846	8	pylori	pylori	NN
cord-001835-0s7ok4uw	1846	9	HP0268	HP0268	NNP
cord-001835-0s7ok4uw	1846	10	as	as	IN
cord-001835-0s7ok4uw	1846	11	a	a	DT
cord-001835-0s7ok4uw	1846	12	nuclease	nuclease	NN
cord-001835-0s7ok4uw	1846	13	with	with	IN
cord-001835-0s7ok4uw	1846	14	both	both	CC
cord-001835-0s7ok4uw	1846	15	DNA	dna	NN
cord-001835-0s7ok4uw	1846	16	nicking	nicking	NN
cord-001835-0s7ok4uw	1846	17	and	and	CC
cord-001835-0s7ok4uw	1846	18	Rnase	Rnase	NNP
cord-001835-0s7ok4uw	1846	19	activities	activity	NNS
cord-001835-0s7ok4uw	1847	1	Bong	Bong	NNP
cord-001835-0s7ok4uw	1847	2	-	-	HYPH
cord-001835-0s7ok4uw	1847	3	Jin	Jin	NNP
cord-001835-0s7ok4uw	1847	4	Lee	Lee	NNP
cord-001835-0s7ok4uw	1847	5	1	1	CD
cord-001835-0s7ok4uw	1847	6	,	,	,
cord-001835-0s7ok4uw	1847	7	Ki	Ki	NNP
cord-001835-0s7ok4uw	1847	8	-	-	HYPH
cord-001835-0s7ok4uw	1847	9	Young	Young	NNP
cord-001835-0s7ok4uw	1847	10	Lee	Lee	NNP
cord-001835-0s7ok4uw	1848	1	1	1	CD
cord-001835-0s7ok4uw	1848	2	1	1	CD
cord-001835-0s7ok4uw	1848	3	HP0268	hp0268	NN
cord-001835-0s7ok4uw	1848	4	is	be	VBZ
cord-001835-0s7ok4uw	1848	5	a	a	DT
cord-001835-0s7ok4uw	1848	6	conserved	conserved	JJ
cord-001835-0s7ok4uw	1848	7	,	,	,
cord-001835-0s7ok4uw	1848	8	uncharacterized	uncharacterized	JJ
cord-001835-0s7ok4uw	1848	9	protein	protein	NN
cord-001835-0s7ok4uw	1848	10	from	from	IN
cord-001835-0s7ok4uw	1848	11	Helicobacter	Helicobacter	NNP
cord-001835-0s7ok4uw	1848	12	pylori	pylori	NN
cord-001835-0s7ok4uw	1848	13	.	.	.
cord-001835-0s7ok4uw	1849	1	Here	here	RB
cord-001835-0s7ok4uw	1849	2	,	,	,
cord-001835-0s7ok4uw	1849	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1849	4	determined	determine	VBD
cord-001835-0s7ok4uw	1849	5	the	the	DT
cord-001835-0s7ok4uw	1849	6	solution	solution	NN
cord-001835-0s7ok4uw	1849	7	structure	structure	NN
cord-001835-0s7ok4uw	1849	8	of	of	IN
cord-001835-0s7ok4uw	1849	9	HP0268	HP0268	NNP
cord-001835-0s7ok4uw	1849	10	using	use	VBG
cord-001835-0s7ok4uw	1849	11	three	three	CD
cord-001835-0s7ok4uw	1849	12	-	-	HYPH
cord-001835-0s7ok4uw	1849	13	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	1849	14	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	1849	15	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	1849	16	resonance	resonance	NN
cord-001835-0s7ok4uw	1849	17	(	(	-LRB-
cord-001835-0s7ok4uw	1849	18	NMR	NMR	NNP
cord-001835-0s7ok4uw	1849	19	)	)	-RRB-
cord-001835-0s7ok4uw	1849	20	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1849	21	,	,	,
cord-001835-0s7ok4uw	1849	22	revealing	reveal	VBG
cord-001835-0s7ok4uw	1849	23	that	that	IN
cord-001835-0s7ok4uw	1849	24	this	this	DT
cord-001835-0s7ok4uw	1849	25	protein	protein	NN
cord-001835-0s7ok4uw	1849	26	is	be	VBZ
cord-001835-0s7ok4uw	1849	27	structurally	structurally	RB
cord-001835-0s7ok4uw	1849	28	most	most	RBS
cord-001835-0s7ok4uw	1849	29	similar	similar	JJ
cord-001835-0s7ok4uw	1849	30	to	to	IN
cord-001835-0s7ok4uw	1849	31	a	a	DT
cord-001835-0s7ok4uw	1849	32	small	small	JJ
cord-001835-0s7ok4uw	1849	33	MutS	MutS	NNP
cord-001835-0s7ok4uw	1849	34	-	-	HYPH
cord-001835-0s7ok4uw	1849	35	related	relate	VBN
cord-001835-0s7ok4uw	1849	36	(	(	-LRB-
cord-001835-0s7ok4uw	1849	37	SMR	SMR	NNP
cord-001835-0s7ok4uw	1849	38	)	)	-RRB-
cord-001835-0s7ok4uw	1849	39	domain	domain	NN
cord-001835-0s7ok4uw	1849	40	that	that	WDT
cord-001835-0s7ok4uw	1849	41	exhibits	exhibit	VBZ
cord-001835-0s7ok4uw	1849	42	nicking	nick	VBG
cord-001835-0s7ok4uw	1849	43	endonuclease	endonuclease	NN
cord-001835-0s7ok4uw	1849	44	activity	activity	NN
cord-001835-0s7ok4uw	1849	45	.	.	.
cord-001835-0s7ok4uw	1850	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1850	2	also	also	RB
cord-001835-0s7ok4uw	1850	3	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	1850	4	for	for	IN
cord-001835-0s7ok4uw	1850	5	the	the	DT
cord-001835-0s7ok4uw	1850	6	first	first	JJ
cord-001835-0s7ok4uw	1850	7	time	time	NN
cord-001835-0s7ok4uw	1850	8	that	that	WDT
cord-001835-0s7ok4uw	1850	9	HP0268	HP0268	NNP
cord-001835-0s7ok4uw	1850	10	is	be	VBZ
cord-001835-0s7ok4uw	1850	11	a	a	DT
cord-001835-0s7ok4uw	1850	12	nicking	nicking	NN
cord-001835-0s7ok4uw	1850	13	endonuclease	endonuclease	NN
cord-001835-0s7ok4uw	1850	14	and	and	CC
cord-001835-0s7ok4uw	1850	15	a	a	DT
cord-001835-0s7ok4uw	1850	16	purine	purine	NN
cord-001835-0s7ok4uw	1850	17	-	-	HYPH
cord-001835-0s7ok4uw	1850	18	specific	specific	JJ
cord-001835-0s7ok4uw	1850	19	ribonuclease	ribonuclease	NN
cord-001835-0s7ok4uw	1850	20	through	through	IN
cord-001835-0s7ok4uw	1850	21	gel	gel	NN
cord-001835-0s7ok4uw	1850	22	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	1850	23	and	and	CC
cord-001835-0s7ok4uw	1850	24	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	1850	25	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1850	26	.	.	.
cord-001835-0s7ok4uw	1851	1	The	the	DT
cord-001835-0s7ok4uw	1851	2	nuclease	nuclease	NN
cord-001835-0s7ok4uw	1851	3	activities	activitie	VBZ
cord-001835-0s7ok4uw	1851	4	for	for	IN
cord-001835-0s7ok4uw	1851	5	DNA	DNA	NNP
cord-001835-0s7ok4uw	1851	6	and	and	CC
cord-001835-0s7ok4uw	1851	7	RNA	RNA	NNP
cord-001835-0s7ok4uw	1851	8	were	be	VBD
cord-001835-0s7ok4uw	1851	9	maximally	maximally	RB
cord-001835-0s7ok4uw	1851	10	increased	increase	VBN
cord-001835-0s7ok4uw	1851	11	by	by	IN
cord-001835-0s7ok4uw	1851	12	Mn(21	Mn(21	NNS
cord-001835-0s7ok4uw	1851	13	)	)	-RRB-
cord-001835-0s7ok4uw	1851	14	and	and	CC
cord-001835-0s7ok4uw	1851	15	Mg(21	Mg(21	NNS
cord-001835-0s7ok4uw	1851	16	)	)	-RRB-
cord-001835-0s7ok4uw	1851	17	ions	ion	NNS
cord-001835-0s7ok4uw	1851	18	,	,	,
cord-001835-0s7ok4uw	1851	19	respectively	respectively	RB
cord-001835-0s7ok4uw	1851	20	,	,	,
cord-001835-0s7ok4uw	1851	21	and	and	CC
cord-001835-0s7ok4uw	1851	22	decreased	decrease	VBD
cord-001835-0s7ok4uw	1851	23	by	by	IN
cord-001835-0s7ok4uw	1851	24	Cu	Cu	NNP
cord-001835-0s7ok4uw	1851	25	(	(	-LRB-
cord-001835-0s7ok4uw	1851	26	21	21	CD
cord-001835-0s7ok4uw	1851	27	)	)	-RRB-
cord-001835-0s7ok4uw	1851	28	ions	ion	NNS
cord-001835-0s7ok4uw	1851	29	.	.	.
cord-001835-0s7ok4uw	1852	1	Using	use	VBG
cord-001835-0s7ok4uw	1852	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	1852	3	chemical	chemical	NN
cord-001835-0s7ok4uw	1852	4	shift	shift	NN
cord-001835-0s7ok4uw	1852	5	perturbations	perturbation	NNS
cord-001835-0s7ok4uw	1852	6	,	,	,
cord-001835-0s7ok4uw	1852	7	the	the	DT
cord-001835-0s7ok4uw	1852	8	metal	metal	NN
cord-001835-0s7ok4uw	1852	9	and	and	CC
cord-001835-0s7ok4uw	1852	10	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	1852	11	binding	binding	NN
cord-001835-0s7ok4uw	1852	12	sites	site	NNS
cord-001835-0s7ok4uw	1852	13	of	of	IN
cord-001835-0s7ok4uw	1852	14	HP0268	HP0268	NNP
cord-001835-0s7ok4uw	1852	15	were	be	VBD
cord-001835-0s7ok4uw	1852	16	determined	determine	VBN
cord-001835-0s7ok4uw	1852	17	to	to	TO
cord-001835-0s7ok4uw	1852	18	be	be	VB
cord-001835-0s7ok4uw	1852	19	spatially	spatially	RB
cord-001835-0s7ok4uw	1852	20	divided	divided	JJ
cord-001835-0s7ok4uw	1852	21	but	but	CC
cord-001835-0s7ok4uw	1852	22	close	close	JJ
cord-001835-0s7ok4uw	1852	23	to	to	IN
cord-001835-0s7ok4uw	1852	24	each	each	DT
cord-001835-0s7ok4uw	1852	25	other	other	JJ
cord-001835-0s7ok4uw	1852	26	.	.	.
cord-001835-0s7ok4uw	1853	1	The	the	DT
cord-001835-0s7ok4uw	1853	2	lysine	lysine	NN
cord-001835-0s7ok4uw	1853	3	residues	residue	NNS
cord-001835-0s7ok4uw	1853	4	(	(	-LRB-
cord-001835-0s7ok4uw	1853	5	Lys7	Lys7	NNP
cord-001835-0s7ok4uw	1853	6	,	,	,
cord-001835-0s7ok4uw	1853	7	Lys11	Lys11	NNP
cord-001835-0s7ok4uw	1853	8	and	and	CC
cord-001835-0s7ok4uw	1853	9	Lys43	Lys43	NNP
cord-001835-0s7ok4uw	1853	10	)	)	-RRB-
cord-001835-0s7ok4uw	1853	11	are	be	VBP
cord-001835-0s7ok4uw	1853	12	clustered	cluster	VBN
cord-001835-0s7ok4uw	1853	13	and	and	CC
cord-001835-0s7ok4uw	1853	14	form	form	VB
cord-001835-0s7ok4uw	1853	15	the	the	DT
cord-001835-0s7ok4uw	1853	16	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	1853	17	binding	bind	VBG
cord-001835-0s7ok4uw	1853	18	site	site	NN
cord-001835-0s7ok4uw	1853	19	.	.	.
cord-001835-0s7ok4uw	1854	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	1854	2	,	,	,
cord-001835-0s7ok4uw	1854	3	site	site	NN
cord-001835-0s7ok4uw	1854	4	-	-	HYPH
cord-001835-0s7ok4uw	1854	5	directed	direct	VBN
cord-001835-0s7ok4uw	1854	6	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	1854	7	was	be	VBD
cord-001835-0s7ok4uw	1854	8	used	use	VBN
cord-001835-0s7ok4uw	1854	9	to	to	TO
cord-001835-0s7ok4uw	1854	10	define	define	VB
cord-001835-0s7ok4uw	1854	11	the	the	DT
cord-001835-0s7ok4uw	1854	12	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1854	13	active	active	JJ
cord-001835-0s7ok4uw	1854	14	site	site	NN
cord-001835-0s7ok4uw	1854	15	of	of	IN
cord-001835-0s7ok4uw	1854	16	HP0268	HP0268	NNP
cord-001835-0s7ok4uw	1854	17	,	,	,
cord-001835-0s7ok4uw	1854	18	revealing	reveal	VBG
cord-001835-0s7ok4uw	1854	19	that	that	IN
cord-001835-0s7ok4uw	1854	20	this	this	DT
cord-001835-0s7ok4uw	1854	21	site	site	NN
cord-001835-0s7ok4uw	1854	22	contains	contain	VBZ
cord-001835-0s7ok4uw	1854	23	two	two	CD
cord-001835-0s7ok4uw	1854	24	acidic	acidic	JJ
cord-001835-0s7ok4uw	1854	25	residues	residue	NNS
cord-001835-0s7ok4uw	1854	26	,	,	,
cord-001835-0s7ok4uw	1854	27	Asp50	Asp50	NNP
cord-001835-0s7ok4uw	1854	28	and	and	CC
cord-001835-0s7ok4uw	1854	29	Glu54	Glu54	NNP
cord-001835-0s7ok4uw	1854	30	,	,	,
cord-001835-0s7ok4uw	1854	31	in	in	IN
cord-001835-0s7ok4uw	1854	32	the	the	DT
cord-001835-0s7ok4uw	1854	33	metal	metal	NN
cord-001835-0s7ok4uw	1854	34	binding	bind	VBG
cord-001835-0s7ok4uw	1854	35	site	site	NN
cord-001835-0s7ok4uw	1854	36	.	.	.
cord-001835-0s7ok4uw	1855	1	The	the	DT
cord-001835-0s7ok4uw	1855	2	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	1855	3	binding	binding	NN
cord-001835-0s7ok4uw	1855	4	and	and	CC
cord-001835-0s7ok4uw	1855	5	active	active	JJ
cord-001835-0s7ok4uw	1855	6	sites	site	NNS
cord-001835-0s7ok4uw	1855	7	are	be	VBP
cord-001835-0s7ok4uw	1855	8	not	not	RB
cord-001835-0s7ok4uw	1855	9	conserved	conserve	VBN
cord-001835-0s7ok4uw	1855	10	in	in	IN
cord-001835-0s7ok4uw	1855	11	the	the	DT
cord-001835-0s7ok4uw	1855	12	structural	structural	JJ
cord-001835-0s7ok4uw	1855	13	homologues	homologue	NNS
cord-001835-0s7ok4uw	1855	14	of	of	IN
cord-001835-0s7ok4uw	1855	15	HP0268	hp0268	NN
cord-001835-0s7ok4uw	1855	16	.	.	.
cord-001835-0s7ok4uw	1856	1	This	this	DT
cord-001835-0s7ok4uw	1856	2	study	study	NN
cord-001835-0s7ok4uw	1856	3	will	will	MD
cord-001835-0s7ok4uw	1856	4	contribute	contribute	VB
cord-001835-0s7ok4uw	1856	5	to	to	IN
cord-001835-0s7ok4uw	1856	6	improving	improve	VBG
cord-001835-0s7ok4uw	1856	7	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1856	8	understanding	understanding	NN
cord-001835-0s7ok4uw	1856	9	of	of	IN
cord-001835-0s7ok4uw	1856	10	the	the	DT
cord-001835-0s7ok4uw	1856	11	structure	structure	NN
cord-001835-0s7ok4uw	1856	12	and	and	CC
cord-001835-0s7ok4uw	1856	13	functionality	functionality	NN
cord-001835-0s7ok4uw	1856	14	of	of	IN
cord-001835-0s7ok4uw	1856	15	a	a	DT
cord-001835-0s7ok4uw	1856	16	wide	wide	JJ
cord-001835-0s7ok4uw	1856	17	spectrum	spectrum	NN
cord-001835-0s7ok4uw	1856	18	of	of	IN
cord-001835-0s7ok4uw	1856	19	nucleases	nuclease	NNS
cord-001835-0s7ok4uw	1856	20	.	.	.
cord-001835-0s7ok4uw	1857	1	High	high	JJ
cord-001835-0s7ok4uw	1857	2	-	-	HYPH
cord-001835-0s7ok4uw	1857	3	fidelity	fidelity	NN
cord-001835-0s7ok4uw	1857	4	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1857	5	protein	protein	NN
cord-001835-0s7ok4uw	1857	6	production	production	NN
cord-001835-0s7ok4uw	1857	7	in	in	IN
cord-001835-0s7ok4uw	1857	8	a	a	DT
cord-001835-0s7ok4uw	1857	9	silkworm	silkworm	NN
cord-001835-0s7ok4uw	1857	10	bioreactor	bioreactor	NN
cord-001835-0s7ok4uw	1857	11	Sungjo	Sungjo	NNP
cord-001835-0s7ok4uw	1857	12	Park	Park	NNP
cord-001835-0s7ok4uw	1857	13	1	1	CD
cord-001835-0s7ok4uw	1857	14	,	,	,
cord-001835-0s7ok4uw	1857	15	In	in	IN
cord-001835-0s7ok4uw	1857	16	-	-	HYPH
cord-001835-0s7ok4uw	1857	17	Wook	Wook	NNP
cord-001835-0s7ok4uw	1857	18	Hwang	Hwang	NNP
cord-001835-0s7ok4uw	1857	19	1	1	CD
cord-001835-0s7ok4uw	1857	20	,	,	,
cord-001835-0s7ok4uw	1857	21	Tatsuya	Tatsuya	NNP
cord-001835-0s7ok4uw	1857	22	Kato	Kato	NNP
cord-001835-0s7ok4uw	1857	23	2	2	CD
cord-001835-0s7ok4uw	1857	24	,	,	,
cord-001835-0s7ok4uw	1857	25	Enoch	Enoch	NNP
cord-001835-0s7ok4uw	1857	26	Park	Park	NNP
cord-001835-0s7ok4uw	1857	27	2	2	CD
cord-001835-0s7ok4uw	1857	28	,	,	,
cord-001835-0s7ok4uw	1857	29	Andre	Andre	NNP
cord-001835-0s7ok4uw	1857	30	Terzic	Terzic	NNP
cord-001835-0s7ok4uw	1857	31	1	1	CD
cord-001835-0s7ok4uw	1857	32	1	1	CD
cord-001835-0s7ok4uw	1857	33	Center	Center	NNP
cord-001835-0s7ok4uw	1857	34	for	for	IN
cord-001835-0s7ok4uw	1857	35	Regenerative	Regenerative	NNP
cord-001835-0s7ok4uw	1857	36	Medicine	Medicine	NNP
cord-001835-0s7ok4uw	1857	37	,	,	,
cord-001835-0s7ok4uw	1857	38	Mayo	Mayo	NNP
cord-001835-0s7ok4uw	1857	39	Clinic	Clinic	NNP
cord-001835-0s7ok4uw	1857	40	,	,	,
cord-001835-0s7ok4uw	1857	41	2	2	CD
cord-001835-0s7ok4uw	1857	42	Laboratory	Laboratory	NNP
cord-001835-0s7ok4uw	1857	43	of	of	IN
cord-001835-0s7ok4uw	1857	44	Biotechnology	Biotechnology	NNP
cord-001835-0s7ok4uw	1857	45	,	,	,
cord-001835-0s7ok4uw	1857	46	Shizuoka	Shizuoka	NNP
cord-001835-0s7ok4uw	1857	47	University	University	NNP
cord-001835-0s7ok4uw	1858	1	The	the	DT
cord-001835-0s7ok4uw	1858	2	domesticated	domesticated	JJ
cord-001835-0s7ok4uw	1858	3	silkworm	silkworm	NN
cord-001835-0s7ok4uw	1858	4	,	,	,
cord-001835-0s7ok4uw	1858	5	Bombyx	Bombyx	NNP
cord-001835-0s7ok4uw	1858	6	mori	mori	NNP
cord-001835-0s7ok4uw	1858	7	,	,	,
cord-001835-0s7ok4uw	1858	8	is	be	VBZ
cord-001835-0s7ok4uw	1858	9	an	an	DT
cord-001835-0s7ok4uw	1858	10	attractive	attractive	JJ
cord-001835-0s7ok4uw	1858	11	host	host	NN
cord-001835-0s7ok4uw	1858	12	naturally	naturally	RB
cord-001835-0s7ok4uw	1858	13	equipped	equip	VBN
cord-001835-0s7ok4uw	1858	14	with	with	IN
cord-001835-0s7ok4uw	1858	15	a	a	DT
cord-001835-0s7ok4uw	1858	16	proficient	proficient	JJ
cord-001835-0s7ok4uw	1858	17	posttranslational	posttranslational	JJ
cord-001835-0s7ok4uw	1858	18	modification	modification	NN
cord-001835-0s7ok4uw	1858	19	machinery	machinery	NN
cord-001835-0s7ok4uw	1858	20	adequate	adequate	JJ
cord-001835-0s7ok4uw	1858	21	to	to	TO
cord-001835-0s7ok4uw	1858	22	fulfill	fulfill	VB
cord-001835-0s7ok4uw	1858	23	stringent	stringent	JJ
cord-001835-0s7ok4uw	1858	24	demands	demand	NNS
cord-001835-0s7ok4uw	1858	25	of	of	IN
cord-001835-0s7ok4uw	1858	26	authentic	authentic	JJ
cord-001835-0s7ok4uw	1858	27	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1858	28	protein	protein	NN
cord-001835-0s7ok4uw	1858	29	production	production	NN
cord-001835-0s7ok4uw	1858	30	.	.	.
cord-001835-0s7ok4uw	1859	1	Silkworm	silkworm	NN
cord-001835-0s7ok4uw	1859	2	-	-	HYPH
cord-001835-0s7ok4uw	1859	3	based	base	VBN
cord-001835-0s7ok4uw	1859	4	protein	protein	NN
cord-001835-0s7ok4uw	1859	5	expression	expression	NN
cord-001835-0s7ok4uw	1859	6	has	have	VBZ
cord-001835-0s7ok4uw	1859	7	originally	originally	RB
cord-001835-0s7ok4uw	1859	8	relied	rely	VBN
cord-001835-0s7ok4uw	1859	9	on	on	IN
cord-001835-0s7ok4uw	1859	10	a	a	DT
cord-001835-0s7ok4uw	1859	11	prototype	prototype	NN
cord-001835-0s7ok4uw	1859	12	baculovirus	baculovirus	NN
cord-001835-0s7ok4uw	1859	13	vector	vector	NN
cord-001835-0s7ok4uw	1859	14	system	system	NN
cord-001835-0s7ok4uw	1859	15	that	that	WDT
cord-001835-0s7ok4uw	1859	16	employs	employ	VBZ
cord-001835-0s7ok4uw	1859	17	silkworm	silkworm	NN
cord-001835-0s7ok4uw	1859	18	as	as	IN
cord-001835-0s7ok4uw	1859	19	a	a	DT
cord-001835-0s7ok4uw	1859	20	bioreactor	bioreactor	NN
cord-001835-0s7ok4uw	1859	21	in	in	IN
cord-001835-0s7ok4uw	1859	22	place	place	NN
cord-001835-0s7ok4uw	1859	23	of	of	IN
cord-001835-0s7ok4uw	1859	24	more	more	JJR
cord-001835-0s7ok4uw	1859	25	traditional	traditional	JJ
cord-001835-0s7ok4uw	1859	26	cell	cell	NN
cord-001835-0s7ok4uw	1859	27	lines	line	NNS
cord-001835-0s7ok4uw	1859	28	.	.	.
cord-001835-0s7ok4uw	1860	1	Recent	recent	JJ
cord-001835-0s7ok4uw	1860	2	development	development	NN
cord-001835-0s7ok4uw	1860	3	of	of	IN
cord-001835-0s7ok4uw	1860	4	the	the	DT
cord-001835-0s7ok4uw	1860	5	silkworm	silkworm	NN
cord-001835-0s7ok4uw	1860	6	trophic	trophic	NNP
cord-001835-0s7ok4uw	1860	7	B.	B.	NNP
cord-001835-0s7ok4uw	1860	8	mori	mori	NNP
cord-001835-0s7ok4uw	1860	9	nucleopolyhedrovirus	nucleopolyhedrovirus	NNP
cord-001835-0s7ok4uw	1860	10	(	(	-LRB-
cord-001835-0s7ok4uw	1860	11	BmNPV	BmNPV	NNP
cord-001835-0s7ok4uw	1860	12	)	)	-RRB-
cord-001835-0s7ok4uw	1860	13	bacmid	bacmid	NNP
cord-001835-0s7ok4uw	1860	14	launches	launch	VBZ
cord-001835-0s7ok4uw	1860	15	a	a	DT
cord-001835-0s7ok4uw	1860	16	second	second	JJ
cord-001835-0s7ok4uw	1860	17	generation	generation	NN
cord-001835-0s7ok4uw	1860	18	of	of	IN
cord-001835-0s7ok4uw	1860	19	silkworm	silkworm	NN
cord-001835-0s7ok4uw	1860	20	-	-	HYPH
cord-001835-0s7ok4uw	1860	21	based	base	VBN
cord-001835-0s7ok4uw	1860	22	protein	protein	NN
cord-001835-0s7ok4uw	1860	23	production	production	NN
cord-001835-0s7ok4uw	1860	24	technology	technology	NN
cord-001835-0s7ok4uw	1860	25	.	.	.
cord-001835-0s7ok4uw	1861	1	Introducing	introduce	VBG
cord-001835-0s7ok4uw	1861	2	the	the	DT
cord-001835-0s7ok4uw	1861	3	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1861	4	bacmid	bacmid	NNP
cord-001835-0s7ok4uw	1861	5	DNA	DNA	NNP
cord-001835-0s7ok4uw	1861	6	into	into	IN
cord-001835-0s7ok4uw	1861	7	silkworms	silkworm	NNS
cord-001835-0s7ok4uw	1861	8	expedites	expedite	VBZ
cord-001835-0s7ok4uw	1861	9	heterologous	heterologous	JJ
cord-001835-0s7ok4uw	1861	10	protein	protein	NN
cord-001835-0s7ok4uw	1861	11	expression	expression	NN
cord-001835-0s7ok4uw	1861	12	by	by	IN
cord-001835-0s7ok4uw	1861	13	eliminating	eliminate	VBG
cord-001835-0s7ok4uw	1861	14	prior	prior	JJ
cord-001835-0s7ok4uw	1861	15	virus	virus	NN
cord-001835-0s7ok4uw	1861	16	construction	construction	NN
cord-001835-0s7ok4uw	1861	17	and	and	CC
cord-001835-0s7ok4uw	1861	18	amplification	amplification	NN
cord-001835-0s7ok4uw	1861	19	steps	step	NNS
cord-001835-0s7ok4uw	1861	20	.	.	.
cord-001835-0s7ok4uw	1862	1	Salient	salient	JJ
cord-001835-0s7ok4uw	1862	2	examples	example	NNS
cord-001835-0s7ok4uw	1862	3	of	of	IN
cord-001835-0s7ok4uw	1862	4	heterologous	heterologous	JJ
cord-001835-0s7ok4uw	1862	5	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	1862	6	proteins	protein	NNS
cord-001835-0s7ok4uw	1862	7	produced	produce	VBN
cord-001835-0s7ok4uw	1862	8	in	in	IN
cord-001835-0s7ok4uw	1862	9	silkworms	silkworm	NNS
cord-001835-0s7ok4uw	1862	10	are	be	VBP
cord-001835-0s7ok4uw	1862	11	acetyl	acetyl	NN
cord-001835-0s7ok4uw	1862	12	-	-	HYPH
cord-001835-0s7ok4uw	1862	13	CoA	coa	NN
cord-001835-0s7ok4uw	1862	14	carboxylase	carboxylase	NN
cord-001835-0s7ok4uw	1862	15	2	2	CD
cord-001835-0s7ok4uw	1862	16	,	,	,
cord-001835-0s7ok4uw	1862	17	malonyl	malonyl	NNP
cord-001835-0s7ok4uw	1862	18	-	-	HYPH
cord-001835-0s7ok4uw	1862	19	CoA	coa	NN
cord-001835-0s7ok4uw	1862	20	decarboxylase	decarboxylase	NN
cord-001835-0s7ok4uw	1862	21	,	,	,
cord-001835-0s7ok4uw	1862	22	Spot14	Spot14	NNP
cord-001835-0s7ok4uw	1862	23	/	/	SYM
cord-001835-0s7ok4uw	1862	24	Mig12	Mig12	NNP
cord-001835-0s7ok4uw	1862	25	heterodimer	heterodimer	NN
cord-001835-0s7ok4uw	1862	26	and	and	CC
cord-001835-0s7ok4uw	1862	27	a2,6-sialyltransferase	a2,6-sialyltransferase	XX
cord-001835-0s7ok4uw	1862	28	with	with	IN
cord-001835-0s7ok4uw	1862	29	consistent	consistent	JJ
cord-001835-0s7ok4uw	1862	30	high	high	JJ
cord-001835-0s7ok4uw	1862	31	levels	level	NNS
cord-001835-0s7ok4uw	1862	32	of	of	IN
cord-001835-0s7ok4uw	1862	33	protein	protein	NN
cord-001835-0s7ok4uw	1862	34	expression	expression	NN
cord-001835-0s7ok4uw	1862	35	.	.	.
cord-001835-0s7ok4uw	1863	1	Thus	thus	RB
cord-001835-0s7ok4uw	1863	2	,	,	,
cord-001835-0s7ok4uw	1863	3	equipped	equip	VBN
cord-001835-0s7ok4uw	1863	4	with	with	IN
cord-001835-0s7ok4uw	1863	5	a	a	DT
cord-001835-0s7ok4uw	1863	6	fail	fail	VB
cord-001835-0s7ok4uw	1863	7	-	-	HYPH
cord-001835-0s7ok4uw	1863	8	safe	safe	JJ
cord-001835-0s7ok4uw	1863	9	post	post	JJ
cord-001835-0s7ok4uw	1863	10	-	-	JJ
cord-001835-0s7ok4uw	1863	11	translational	translational	JJ
cord-001835-0s7ok4uw	1863	12	modification	modification	NN
cord-001835-0s7ok4uw	1863	13	machinery	machinery	NN
cord-001835-0s7ok4uw	1863	14	,	,	,
cord-001835-0s7ok4uw	1863	15	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	1863	16	proteins	protein	NNS
cord-001835-0s7ok4uw	1863	17	are	be	VBP
cord-001835-0s7ok4uw	1863	18	readily	readily	RB
cord-001835-0s7ok4uw	1863	19	bioengineered	bioengineere	VBN
cord-001835-0s7ok4uw	1863	20	using	use	VBG
cord-001835-0s7ok4uw	1863	21	a	a	DT
cord-001835-0s7ok4uw	1863	22	silkworm	silkworm	NN
cord-001835-0s7ok4uw	1863	23	-	-	HYPH
cord-001835-0s7ok4uw	1863	24	based	base	VBN
cord-001835-0s7ok4uw	1863	25	protein	protein	NN
cord-001835-0s7ok4uw	1863	26	expression	expression	NN
cord-001835-0s7ok4uw	1863	27	platform	platform	NN
cord-001835-0s7ok4uw	1863	28	.	.	.
cord-001835-0s7ok4uw	1864	1	Studies	study	NNS
cord-001835-0s7ok4uw	1864	2	exploring	explore	VBG
cord-001835-0s7ok4uw	1864	3	potential	potential	JJ
cord-001835-0s7ok4uw	1864	4	applications	application	NNS
cord-001835-0s7ok4uw	1864	5	of	of	IN
cord-001835-0s7ok4uw	1864	6	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	1864	7	antifreeze	antifreeze	NN
cord-001835-0s7ok4uw	1864	8	proteins	protein	NNS
cord-001835-0s7ok4uw	1864	9	in	in	IN
cord-001835-0s7ok4uw	1864	10	the	the	DT
cord-001835-0s7ok4uw	1864	11	frozen	frozen	JJ
cord-001835-0s7ok4uw	1864	12	food	food	NN
cord-001835-0s7ok4uw	1864	13	industry	industry	NN
cord-001835-0s7ok4uw	1864	14	Ho	Ho	NNP
cord-001835-0s7ok4uw	1864	15	Zee	Zee	NNP
cord-001835-0s7ok4uw	1864	16	(	(	-LRB-
cord-001835-0s7ok4uw	1864	17	Charles	Charles	NNP
cord-001835-0s7ok4uw	1864	18	)	)	-RRB-
cord-001835-0s7ok4uw	1864	19	Kong	Kong	NNP
cord-001835-0s7ok4uw	1864	20	1	1	CD
cord-001835-0s7ok4uw	1864	21	,	,	,
cord-001835-0s7ok4uw	1864	22	Conrad	Conrad	NNP
cord-001835-0s7ok4uw	1864	23	Perera	Perera	NNP
cord-001835-0s7ok4uw	1864	24	1	1	CD
cord-001835-0s7ok4uw	1864	25	,	,	,
cord-001835-0s7ok4uw	1864	26	Ivanhoe	Ivanhoe	NNP
cord-001835-0s7ok4uw	1864	27	Leung	Leung	NNP
cord-001835-0s7ok4uw	1864	28	1	1	CD
cord-001835-0s7ok4uw	1864	29	,	,	,
cord-001835-0s7ok4uw	1864	30	Nazimah	Nazimah	NNP
cord-001835-0s7ok4uw	1864	31	Hamid	Hamid	NNP
cord-001835-0s7ok4uw	1864	32	2	2	CD
cord-001835-0s7ok4uw	1864	33	,	,	,
cord-001835-0s7ok4uw	1864	34	Viji	Viji	NNP
cord-001835-0s7ok4uw	1864	35	Sarojini	Sarojini	NNP
cord-001835-0s7ok4uw	1864	36	1	1	CD
cord-001835-0s7ok4uw	1864	37	1	1	CD
cord-001835-0s7ok4uw	1864	38	School	School	NNP
cord-001835-0s7ok4uw	1864	39	of	of	IN
cord-001835-0s7ok4uw	1864	40	Chemical	Chemical	NNP
cord-001835-0s7ok4uw	1864	41	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	1864	42	,	,	,
cord-001835-0s7ok4uw	1864	43	The	the	DT
cord-001835-0s7ok4uw	1864	44	University	University	NNP
cord-001835-0s7ok4uw	1864	45	of	of	IN
cord-001835-0s7ok4uw	1864	46	Auckland	Auckland	NNP
cord-001835-0s7ok4uw	1864	47	.	.	.
cord-001835-0s7ok4uw	1865	1	,	,	,
cord-001835-0s7ok4uw	1865	2	2	2	CD
cord-001835-0s7ok4uw	1865	3	School	School	NNP
cord-001835-0s7ok4uw	1865	4	of	of	IN
cord-001835-0s7ok4uw	1865	5	Applied	Applied	NNP
cord-001835-0s7ok4uw	1865	6	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	1865	7	,	,	,
cord-001835-0s7ok4uw	1865	8	Auckland	Auckland	NNP
cord-001835-0s7ok4uw	1865	9	University	University	NNP
cord-001835-0s7ok4uw	1865	10	of	of	IN
cord-001835-0s7ok4uw	1865	11	Technology	Technology	NNP
cord-001835-0s7ok4uw	1866	1	In	in	IN
cord-001835-0s7ok4uw	1866	2	nature	nature	NN
cord-001835-0s7ok4uw	1866	3	,	,	,
cord-001835-0s7ok4uw	1866	4	certain	certain	JJ
cord-001835-0s7ok4uw	1866	5	species	specie	NNS
cord-001835-0s7ok4uw	1866	6	of	of	IN
cord-001835-0s7ok4uw	1866	7	plants	plant	NNS
cord-001835-0s7ok4uw	1866	8	,	,	,
cord-001835-0s7ok4uw	1866	9	insects	insect	NNS
cord-001835-0s7ok4uw	1866	10	and	and	CC
cord-001835-0s7ok4uw	1866	11	fish	fish	NN
cord-001835-0s7ok4uw	1866	12	produce	produce	VBP
cord-001835-0s7ok4uw	1866	13	a	a	DT
cord-001835-0s7ok4uw	1866	14	group	group	NN
cord-001835-0s7ok4uw	1866	15	of	of	IN
cord-001835-0s7ok4uw	1866	16	antifreeze	antifreeze	NN
cord-001835-0s7ok4uw	1866	17	glycoproteins	glycoprotein	NNS
cord-001835-0s7ok4uw	1866	18	and	and	CC
cord-001835-0s7ok4uw	1866	19	polypeptides	polypeptide	NNS
cord-001835-0s7ok4uw	1866	20	which	which	WDT
cord-001835-0s7ok4uw	1866	21	enable	enable	VBP
cord-001835-0s7ok4uw	1866	22	them	-PRON-	PRP
cord-001835-0s7ok4uw	1866	23	to	to	TO
cord-001835-0s7ok4uw	1866	24	survive	survive	VB
cord-001835-0s7ok4uw	1866	25	the	the	DT
cord-001835-0s7ok4uw	1866	26	freezing	freeze	VBG
cord-001835-0s7ok4uw	1866	27	temperatures	temperature	NNS
cord-001835-0s7ok4uw	1866	28	of	of	IN
cord-001835-0s7ok4uw	1866	29	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1866	30	natural	natural	JJ
cord-001835-0s7ok4uw	1866	31	habitat	habitat	NN
cord-001835-0s7ok4uw	1866	32	.	.	.
cord-001835-0s7ok4uw	1867	1	These	these	DT
cord-001835-0s7ok4uw	1867	2	naturally	naturally	RB
cord-001835-0s7ok4uw	1867	3	occurring	occur	VBG
cord-001835-0s7ok4uw	1867	4	antifreeze	antifreeze	NN
cord-001835-0s7ok4uw	1867	5	proteins	protein	NNS
cord-001835-0s7ok4uw	1867	6	(	(	-LRB-
cord-001835-0s7ok4uw	1867	7	AFPs	afp	NNS
cord-001835-0s7ok4uw	1867	8	)	)	-RRB-
cord-001835-0s7ok4uw	1867	9	were	be	VBD
cord-001835-0s7ok4uw	1867	10	first	first	RB
cord-001835-0s7ok4uw	1867	11	discovered	discover	VBN
cord-001835-0s7ok4uw	1867	12	in	in	IN
cord-001835-0s7ok4uw	1867	13	polar	polar	JJ
cord-001835-0s7ok4uw	1867	14	fishes	fish	NNS
cord-001835-0s7ok4uw	1867	15	such	such	JJ
cord-001835-0s7ok4uw	1867	16	as	as	IN
cord-001835-0s7ok4uw	1867	17	antarctic	antarctic	NNP
cord-001835-0s7ok4uw	1867	18	notothenioids	notothenioids	NNP
cord-001835-0s7ok4uw	1867	19	and	and	CC
cord-001835-0s7ok4uw	1867	20	winter	winter	NN
cord-001835-0s7ok4uw	1867	21	flounder	flounder	NN
cord-001835-0s7ok4uw	1867	22	.	.	.
cord-001835-0s7ok4uw	1868	1	These	these	DT
cord-001835-0s7ok4uw	1868	2	AFPs	afp	NNS
cord-001835-0s7ok4uw	1868	3	have	have	VBP
cord-001835-0s7ok4uw	1868	4	the	the	DT
cord-001835-0s7ok4uw	1868	5	ability	ability	NN
cord-001835-0s7ok4uw	1868	6	to	to	TO
cord-001835-0s7ok4uw	1868	7	bind	bind	VB
cord-001835-0s7ok4uw	1868	8	to	to	IN
cord-001835-0s7ok4uw	1868	9	ice	ice	NN
cord-001835-0s7ok4uw	1868	10	crystals	crystal	NNS
cord-001835-0s7ok4uw	1868	11	and	and	CC
cord-001835-0s7ok4uw	1868	12	restrict	restrict	VB
cord-001835-0s7ok4uw	1868	13	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1868	14	size	size	NN
cord-001835-0s7ok4uw	1868	15	and	and	CC
cord-001835-0s7ok4uw	1868	16	morphology	morphology	NN
cord-001835-0s7ok4uw	1868	17	;	;	:
cord-001835-0s7ok4uw	1868	18	decrease	decrease	VB
cord-001835-0s7ok4uw	1868	19	the	the	DT
cord-001835-0s7ok4uw	1868	20	freezing	freezing	JJ
cord-001835-0s7ok4uw	1868	21	point	point	NN
cord-001835-0s7ok4uw	1868	22	of	of	IN
cord-001835-0s7ok4uw	1868	23	water	water	NN
cord-001835-0s7ok4uw	1868	24	and	and	CC
cord-001835-0s7ok4uw	1868	25	inhibit	inhibit	VB
cord-001835-0s7ok4uw	1868	26	the	the	DT
cord-001835-0s7ok4uw	1868	27	ice	ice	NN
cord-001835-0s7ok4uw	1868	28	recrystallization	recrystallization	NN
cord-001835-0s7ok4uw	1868	29	processes	process	NNS
cord-001835-0s7ok4uw	1868	30	.	.	.
cord-001835-0s7ok4uw	1869	1	Ice	ice	NN
cord-001835-0s7ok4uw	1869	2	crystal	crystal	NN
cord-001835-0s7ok4uw	1869	3	formation	formation	NN
cord-001835-0s7ok4uw	1869	4	is	be	VBZ
cord-001835-0s7ok4uw	1869	5	of	of	IN
cord-001835-0s7ok4uw	1869	6	primary	primary	JJ
cord-001835-0s7ok4uw	1869	7	concern	concern	NN
cord-001835-0s7ok4uw	1869	8	to	to	IN
cord-001835-0s7ok4uw	1869	9	the	the	DT
cord-001835-0s7ok4uw	1869	10	frozen	frozen	JJ
cord-001835-0s7ok4uw	1869	11	food	food	NN
cord-001835-0s7ok4uw	1869	12	industry	industry	NN
cord-001835-0s7ok4uw	1869	13	,	,	,
cord-001835-0s7ok4uw	1869	14	as	as	IN
cord-001835-0s7ok4uw	1869	15	ice	ice	NN
cord-001835-0s7ok4uw	1869	16	crystal	crystal	NN
cord-001835-0s7ok4uw	1869	17	formation	formation	NN
cord-001835-0s7ok4uw	1869	18	during	during	IN
cord-001835-0s7ok4uw	1869	19	freezing	freezing	NN
cord-001835-0s7ok4uw	1869	20	can	can	MD
cord-001835-0s7ok4uw	1869	21	be	be	VB
cord-001835-0s7ok4uw	1869	22	disruptive	disruptive	JJ
cord-001835-0s7ok4uw	1869	23	to	to	IN
cord-001835-0s7ok4uw	1869	24	and	and	CC
cord-001835-0s7ok4uw	1869	25	cause	cause	VB
cord-001835-0s7ok4uw	1869	26	damage	damage	NN
cord-001835-0s7ok4uw	1869	27	to	to	IN
cord-001835-0s7ok4uw	1869	28	the	the	DT
cord-001835-0s7ok4uw	1869	29	cellular	cellular	JJ
cord-001835-0s7ok4uw	1869	30	structures	structure	NNS
cord-001835-0s7ok4uw	1869	31	in	in	IN
cord-001835-0s7ok4uw	1869	32	food	food	NN
cord-001835-0s7ok4uw	1869	33	.	.	.
cord-001835-0s7ok4uw	1870	1	The	the	DT
cord-001835-0s7ok4uw	1870	2	unique	unique	JJ
cord-001835-0s7ok4uw	1870	3	properties	property	NNS
cord-001835-0s7ok4uw	1870	4	of	of	IN
cord-001835-0s7ok4uw	1870	5	AFPs	afp	NNS
cord-001835-0s7ok4uw	1870	6	can	can	MD
cord-001835-0s7ok4uw	1870	7	be	be	VB
cord-001835-0s7ok4uw	1870	8	developed	develop	VBN
cord-001835-0s7ok4uw	1870	9	into	into	IN
cord-001835-0s7ok4uw	1870	10	a	a	DT
cord-001835-0s7ok4uw	1870	11	potential	potential	JJ
cord-001835-0s7ok4uw	1870	12	solution	solution	NN
cord-001835-0s7ok4uw	1870	13	to	to	TO
cord-001835-0s7ok4uw	1870	14	minimize	minimize	VB
cord-001835-0s7ok4uw	1870	15	freeze	freeze	NN
cord-001835-0s7ok4uw	1870	16	-	-	HYPH
cord-001835-0s7ok4uw	1870	17	thaw	thaw	VB
cord-001835-0s7ok4uw	1870	18	damage	damage	NN
cord-001835-0s7ok4uw	1870	19	to	to	IN
cord-001835-0s7ok4uw	1870	20	frozen	frozen	JJ
cord-001835-0s7ok4uw	1870	21	food	food	NN
cord-001835-0s7ok4uw	1870	22	.	.	.
cord-001835-0s7ok4uw	1871	1	A	a	DT
cord-001835-0s7ok4uw	1871	2	number	number	NN
cord-001835-0s7ok4uw	1871	3	of	of	IN
cord-001835-0s7ok4uw	1871	4	tailor	tailor	NN
cord-001835-0s7ok4uw	1871	5	made	make	VBD
cord-001835-0s7ok4uw	1871	6	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	1871	7	analogues	analogue	NNS
cord-001835-0s7ok4uw	1871	8	based	base	VBN
cord-001835-0s7ok4uw	1871	9	on	on	IN
cord-001835-0s7ok4uw	1871	10	the	the	DT
cord-001835-0s7ok4uw	1871	11	naturally	naturally	RB
cord-001835-0s7ok4uw	1871	12	occurring	occur	VBG
cord-001835-0s7ok4uw	1871	13	AFPs	afp	NNS
cord-001835-0s7ok4uw	1871	14	were	be	VBD
cord-001835-0s7ok4uw	1871	15	successfully	successfully	RB
cord-001835-0s7ok4uw	1871	16	designed	design	VBN
cord-001835-0s7ok4uw	1871	17	and	and	CC
cord-001835-0s7ok4uw	1871	18	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	1871	19	.	.	.
cord-001835-0s7ok4uw	1872	1	Antifreeze	antifreeze	NN
cord-001835-0s7ok4uw	1872	2	activity	activity	NN
cord-001835-0s7ok4uw	1872	3	studies	study	NNS
cord-001835-0s7ok4uw	1872	4	of	of	IN
cord-001835-0s7ok4uw	1872	5	the	the	DT
cord-001835-0s7ok4uw	1872	6	AFPs	afp	NNS
cord-001835-0s7ok4uw	1872	7	were	be	VBD
cord-001835-0s7ok4uw	1872	8	carried	carry	VBN
cord-001835-0s7ok4uw	1872	9	out	out	RP
cord-001835-0s7ok4uw	1872	10	using	use	VBG
cord-001835-0s7ok4uw	1872	11	the	the	DT
cord-001835-0s7ok4uw	1872	12	Clifton	Clifton	NNP
cord-001835-0s7ok4uw	1872	13	nanoliter	nanoliter	NNP
cord-001835-0s7ok4uw	1872	14	osmometer	osmometer	NN
cord-001835-0s7ok4uw	1872	15	attached	attach	VBN
cord-001835-0s7ok4uw	1872	16	with	with	IN
cord-001835-0s7ok4uw	1872	17	a	a	DT
cord-001835-0s7ok4uw	1872	18	microscope	microscope	NN
cord-001835-0s7ok4uw	1872	19	.	.	.
cord-001835-0s7ok4uw	1873	1	The	the	DT
cord-001835-0s7ok4uw	1873	2	AFPs	afp	NNS
cord-001835-0s7ok4uw	1873	3	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	1873	4	thermal	thermal	JJ
cord-001835-0s7ok4uw	1873	5	hysteresis	hysteresis	NN
cord-001835-0s7ok4uw	1873	6	as	as	RB
cord-001835-0s7ok4uw	1873	7	well	well	RB
cord-001835-0s7ok4uw	1873	8	as	as	IN
cord-001835-0s7ok4uw	1873	9	modification	modification	NN
cord-001835-0s7ok4uw	1873	10	of	of	IN
cord-001835-0s7ok4uw	1873	11	ice	ice	NN
cord-001835-0s7ok4uw	1873	12	crystal	crystal	NN
cord-001835-0s7ok4uw	1873	13	morphology	morphology	NN
cord-001835-0s7ok4uw	1873	14	,	,	,
cord-001835-0s7ok4uw	1873	15	confirming	confirm	VBG
cord-001835-0s7ok4uw	1873	16	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1873	17	antifreeze	antifreeze	NN
cord-001835-0s7ok4uw	1873	18	activity	activity	NN
cord-001835-0s7ok4uw	1873	19	in	in	IN
cord-001835-0s7ok4uw	1873	20	vitro	vitro	FW
cord-001835-0s7ok4uw	1873	21	.	.	.
cord-001835-0s7ok4uw	1874	1	The	the	DT
cord-001835-0s7ok4uw	1874	2	ability	ability	NN
cord-001835-0s7ok4uw	1874	3	of	of	IN
cord-001835-0s7ok4uw	1874	4	these	these	DT
cord-001835-0s7ok4uw	1874	5	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	1874	6	AFPs	afp	NNS
cord-001835-0s7ok4uw	1874	7	in	in	IN
cord-001835-0s7ok4uw	1874	8	preserving	preserve	VBG
cord-001835-0s7ok4uw	1874	9	the	the	DT
cord-001835-0s7ok4uw	1874	10	texture	texture	NN
cord-001835-0s7ok4uw	1874	11	and	and	CC
cord-001835-0s7ok4uw	1874	12	structure	structure	NN
cord-001835-0s7ok4uw	1874	13	of	of	IN
cord-001835-0s7ok4uw	1874	14	frozen	frozen	JJ
cord-001835-0s7ok4uw	1874	15	food	food	NN
cord-001835-0s7ok4uw	1874	16	was	be	VBD
cord-001835-0s7ok4uw	1874	17	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	1874	18	using	use	VBG
cord-001835-0s7ok4uw	1874	19	the	the	DT
cord-001835-0s7ok4uw	1874	20	techniques	technique	NNS
cord-001835-0s7ok4uw	1874	21	of	of	IN
cord-001835-0s7ok4uw	1874	22	scanning	scan	VBG
cord-001835-0s7ok4uw	1874	23	electron	electron	NN
cord-001835-0s7ok4uw	1874	24	microscopy	microscopy	NN
cord-001835-0s7ok4uw	1874	25	.	.	.
cord-001835-0s7ok4uw	1875	1	The	the	DT
cord-001835-0s7ok4uw	1875	2	AFPs	afp	NNS
cord-001835-0s7ok4uw	1875	3	showed	show	VBD
cord-001835-0s7ok4uw	1875	4	great	great	JJ
cord-001835-0s7ok4uw	1875	5	potential	potential	NN
cord-001835-0s7ok4uw	1875	6	to	to	TO
cord-001835-0s7ok4uw	1875	7	preserve	preserve	VB
cord-001835-0s7ok4uw	1875	8	the	the	DT
cord-001835-0s7ok4uw	1875	9	cellular	cellular	JJ
cord-001835-0s7ok4uw	1875	10	structures	structure	NNS
cord-001835-0s7ok4uw	1875	11	of	of	IN
cord-001835-0s7ok4uw	1875	12	frozen	frozen	JJ
cord-001835-0s7ok4uw	1875	13	food	food	NN
cord-001835-0s7ok4uw	1875	14	samples	sample	NNS
cord-001835-0s7ok4uw	1875	15	during	during	IN
cord-001835-0s7ok4uw	1875	16	freeze	freeze	NN
cord-001835-0s7ok4uw	1875	17	-	-	HYPH
cord-001835-0s7ok4uw	1875	18	thaw	thaw	NN
cord-001835-0s7ok4uw	1875	19	process	process	NN
cord-001835-0s7ok4uw	1875	20	.	.	.
cord-001835-0s7ok4uw	1876	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	1876	2	,	,	,
cord-001835-0s7ok4uw	1876	3	secondary	secondary	JJ
cord-001835-0s7ok4uw	1876	4	structure	structure	NN
cord-001835-0s7ok4uw	1876	5	analysis	analysis	NN
cord-001835-0s7ok4uw	1876	6	of	of	IN
cord-001835-0s7ok4uw	1876	7	the	the	DT
cord-001835-0s7ok4uw	1876	8	AFPs	AFPs	NNPS
cord-001835-0s7ok4uw	1876	9	was	be	VBD
cord-001835-0s7ok4uw	1876	10	carried	carry	VBN
cord-001835-0s7ok4uw	1876	11	out	out	RP
cord-001835-0s7ok4uw	1876	12	using	use	VBG
cord-001835-0s7ok4uw	1876	13	circular	circular	JJ
cord-001835-0s7ok4uw	1876	14	dichroism	dichroism	NN
cord-001835-0s7ok4uw	1876	15	.	.	.
cord-001835-0s7ok4uw	1877	1	This	this	DT
cord-001835-0s7ok4uw	1877	2	presentation	presentation	NN
cord-001835-0s7ok4uw	1877	3	will	will	MD
cord-001835-0s7ok4uw	1877	4	summarize	summarize	VB
cord-001835-0s7ok4uw	1877	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1877	6	current	current	JJ
cord-001835-0s7ok4uw	1877	7	results	result	NNS
cord-001835-0s7ok4uw	1877	8	on	on	IN
cord-001835-0s7ok4uw	1877	9	the	the	DT
cord-001835-0s7ok4uw	1877	10	design	design	NN
cord-001835-0s7ok4uw	1877	11	,	,	,
cord-001835-0s7ok4uw	1877	12	synthesis	synthesis	NN
cord-001835-0s7ok4uw	1877	13	and	and	CC
cord-001835-0s7ok4uw	1877	14	anti	anti	JJ
cord-001835-0s7ok4uw	1877	15	-	-	JJ
cord-001835-0s7ok4uw	1877	16	freeze	freeze	JJ
cord-001835-0s7ok4uw	1877	17	activity	activity	NN
cord-001835-0s7ok4uw	1877	18	analysis	analysis	NN
cord-001835-0s7ok4uw	1877	19	of	of	IN
cord-001835-0s7ok4uw	1877	20	the	the	DT
cord-001835-0s7ok4uw	1877	21	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	1877	22	AFPs	afp	NNS
cord-001835-0s7ok4uw	1877	23	.	.	.
cord-001835-0s7ok4uw	1878	1	Invasive	invasive	JJ
cord-001835-0s7ok4uw	1878	2	fungal	fungal	JJ
cord-001835-0s7ok4uw	1878	3	infections	infection	NNS
cord-001835-0s7ok4uw	1878	4	remain	remain	VBP
cord-001835-0s7ok4uw	1878	5	a	a	DT
cord-001835-0s7ok4uw	1878	6	leading	leading	JJ
cord-001835-0s7ok4uw	1878	7	cause	cause	NN
cord-001835-0s7ok4uw	1878	8	of	of	IN
cord-001835-0s7ok4uw	1878	9	death	death	NN
cord-001835-0s7ok4uw	1878	10	in	in	IN
cord-001835-0s7ok4uw	1878	11	immunocompromised	immunocompromised	JJ
cord-001835-0s7ok4uw	1878	12	patients	patient	NNS
cord-001835-0s7ok4uw	1878	13	.	.	.
cord-001835-0s7ok4uw	1879	1	Current	current	JJ
cord-001835-0s7ok4uw	1879	2	antifungal	antifungal	JJ
cord-001835-0s7ok4uw	1879	3	agents	agent	NNS
cord-001835-0s7ok4uw	1879	4	have	have	VBP
cord-001835-0s7ok4uw	1879	5	a	a	DT
cord-001835-0s7ok4uw	1879	6	host	host	NN
cord-001835-0s7ok4uw	1879	7	of	of	IN
cord-001835-0s7ok4uw	1879	8	issues	issue	NNS
cord-001835-0s7ok4uw	1879	9	including	include	VBG
cord-001835-0s7ok4uw	1879	10	limited	limited	JJ
cord-001835-0s7ok4uw	1879	11	efficacy	efficacy	NN
cord-001835-0s7ok4uw	1879	12	,	,	,
cord-001835-0s7ok4uw	1879	13	host	host	NN
cord-001835-0s7ok4uw	1879	14	toxicity	toxicity	NN
cord-001835-0s7ok4uw	1879	15	and	and	CC
cord-001835-0s7ok4uw	1879	16	an	an	DT
cord-001835-0s7ok4uw	1879	17	alarming	alarming	JJ
cord-001835-0s7ok4uw	1879	18	increase	increase	NN
cord-001835-0s7ok4uw	1879	19	in	in	IN
cord-001835-0s7ok4uw	1879	20	resistance	resistance	NN
cord-001835-0s7ok4uw	1879	21	.	.	.
cord-001835-0s7ok4uw	1880	1	Current	current	JJ
cord-001835-0s7ok4uw	1880	2	research	research	NN
cord-001835-0s7ok4uw	1880	3	in	in	IN
cord-001835-0s7ok4uw	1880	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1880	5	laboratories	laboratory	NNS
cord-001835-0s7ok4uw	1880	6	is	be	VBZ
cord-001835-0s7ok4uw	1880	7	focused	focus	VBN
cord-001835-0s7ok4uw	1880	8	on	on	IN
cord-001835-0s7ok4uw	1880	9	targeting	target	VBG
cord-001835-0s7ok4uw	1880	10	the	the	DT
cord-001835-0s7ok4uw	1880	11	calcineurin	calcineurin	NN
cord-001835-0s7ok4uw	1880	12	signaling	signal	VBG
cord-001835-0s7ok4uw	1880	13	pathway	pathway	NN
cord-001835-0s7ok4uw	1880	14	that	that	WDT
cord-001835-0s7ok4uw	1880	15	has	have	VBZ
cord-001835-0s7ok4uw	1880	16	been	be	VBN
cord-001835-0s7ok4uw	1880	17	shown	show	VBN
cord-001835-0s7ok4uw	1880	18	to	to	TO
cord-001835-0s7ok4uw	1880	19	be	be	VB
cord-001835-0s7ok4uw	1880	20	required	require	VBN
cord-001835-0s7ok4uw	1880	21	for	for	IN
cord-001835-0s7ok4uw	1880	22	fungal	fungal	JJ
cord-001835-0s7ok4uw	1880	23	pathogenesis	pathogenesis	NN
cord-001835-0s7ok4uw	1880	24	.	.	.
cord-001835-0s7ok4uw	1881	1	Calcineurin	Calcineurin	NNP
cord-001835-0s7ok4uw	1881	2	is	be	VBZ
cord-001835-0s7ok4uw	1881	3	a	a	DT
cord-001835-0s7ok4uw	1881	4	highly	highly	RB
cord-001835-0s7ok4uw	1881	5	conserved	conserve	VBN
cord-001835-0s7ok4uw	1881	6	serine	serine	NN
cord-001835-0s7ok4uw	1881	7	-	-	HYPH
cord-001835-0s7ok4uw	1881	8	threonine	threonine	NN
cord-001835-0s7ok4uw	1881	9	-	-	HYPH
cord-001835-0s7ok4uw	1881	10	specific	specific	JJ
cord-001835-0s7ok4uw	1881	11	Ca21-calmodulin	Ca21-calmodulin	NNP
cord-001835-0s7ok4uw	1881	12	-	-	HYPH
cord-001835-0s7ok4uw	1881	13	activated	activate	VBN
cord-001835-0s7ok4uw	1881	14	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	1881	15	important	important	JJ
cord-001835-0s7ok4uw	1881	16	in	in	IN
cord-001835-0s7ok4uw	1881	17	mediating	mediate	VBG
cord-001835-0s7ok4uw	1881	18	fungal	fungal	JJ
cord-001835-0s7ok4uw	1881	19	pathogenesis	pathogenesis	NN
cord-001835-0s7ok4uw	1881	20	and	and	CC
cord-001835-0s7ok4uw	1881	21	stress	stress	NN
cord-001835-0s7ok4uw	1881	22	responses	response	NNS
cord-001835-0s7ok4uw	1881	23	.	.	.
cord-001835-0s7ok4uw	1882	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1882	2	is	be	VBZ
cord-001835-0s7ok4uw	1882	3	a	a	DT
cord-001835-0s7ok4uw	1882	4	key	key	JJ
cord-001835-0s7ok4uw	1882	5	regulator	regulator	NN
cord-001835-0s7ok4uw	1882	6	of	of	IN
cord-001835-0s7ok4uw	1882	7	a	a	DT
cord-001835-0s7ok4uw	1882	8	signal	signal	NN
cord-001835-0s7ok4uw	1882	9	transduction	transduction	NN
cord-001835-0s7ok4uw	1882	10	network	network	NN
cord-001835-0s7ok4uw	1882	11	required	require	VBN
cord-001835-0s7ok4uw	1882	12	for	for	IN
cord-001835-0s7ok4uw	1882	13	survival	survival	NN
cord-001835-0s7ok4uw	1882	14	of	of	IN
cord-001835-0s7ok4uw	1882	15	the	the	DT
cord-001835-0s7ok4uw	1882	16	most	most	RBS
cord-001835-0s7ok4uw	1882	17	common	common	JJ
cord-001835-0s7ok4uw	1882	18	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	1882	19	fungi	fungus	NNS
cord-001835-0s7ok4uw	1882	20	in	in	IN
cord-001835-0s7ok4uw	1882	21	humans	human	NNS
cord-001835-0s7ok4uw	1882	22	,	,	,
cord-001835-0s7ok4uw	1882	23	making	make	VBG
cord-001835-0s7ok4uw	1882	24	it	-PRON-	PRP
cord-001835-0s7ok4uw	1882	25	an	an	DT
cord-001835-0s7ok4uw	1882	26	ideal	ideal	JJ
cord-001835-0s7ok4uw	1882	27	target	target	NN
cord-001835-0s7ok4uw	1882	28	for	for	IN
cord-001835-0s7ok4uw	1882	29	fungal	fungal	JJ
cord-001835-0s7ok4uw	1882	30	drug	drug	NN
cord-001835-0s7ok4uw	1882	31	development	development	NN
cord-001835-0s7ok4uw	1882	32	.	.	.
cord-001835-0s7ok4uw	1883	1	Calcineurin	Calcineurin	NNP
cord-001835-0s7ok4uw	1883	2	is	be	VBZ
cord-001835-0s7ok4uw	1883	3	a	a	DT
cord-001835-0s7ok4uw	1883	4	heterodimer	heterodimer	NN
cord-001835-0s7ok4uw	1883	5	of	of	IN
cord-001835-0s7ok4uw	1883	6	a	a	DT
cord-001835-0s7ok4uw	1883	7	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1883	8	(	(	-LRB-
cord-001835-0s7ok4uw	1883	9	A	a	NN
cord-001835-0s7ok4uw	1883	10	)	)	-RRB-
cord-001835-0s7ok4uw	1883	11	and	and	CC
cord-001835-0s7ok4uw	1883	12	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	1883	13	(	(	-LRB-
cord-001835-0s7ok4uw	1883	14	B	b	NN
cord-001835-0s7ok4uw	1883	15	)	)	-RRB-
cord-001835-0s7ok4uw	1883	16	subunit	subunit	NN
cord-001835-0s7ok4uw	1883	17	.	.	.
cord-001835-0s7ok4uw	1884	1	Phosphatase	phosphatase	JJ
cord-001835-0s7ok4uw	1884	2	activity	activity	NN
cord-001835-0s7ok4uw	1884	3	requires	require	VBZ
cord-001835-0s7ok4uw	1884	4	association	association	NN
cord-001835-0s7ok4uw	1884	5	of	of	IN
cord-001835-0s7ok4uw	1884	6	the	the	DT
cord-001835-0s7ok4uw	1884	7	two	two	CD
cord-001835-0s7ok4uw	1884	8	subunits	subunit	NNS
cord-001835-0s7ok4uw	1884	9	.	.	.
cord-001835-0s7ok4uw	1885	1	Calcineurin	Calcineurin	NNP
cord-001835-0s7ok4uw	1885	2	is	be	VBZ
cord-001835-0s7ok4uw	1885	3	also	also	RB
cord-001835-0s7ok4uw	1885	4	the	the	DT
cord-001835-0s7ok4uw	1885	5	target	target	NN
cord-001835-0s7ok4uw	1885	6	of	of	IN
cord-001835-0s7ok4uw	1885	7	the	the	DT
cord-001835-0s7ok4uw	1885	8	immunosuppressant	immunosuppressant	JJ
cord-001835-0s7ok4uw	1885	9	FK506	FK506	NNP
cord-001835-0s7ok4uw	1885	10	,	,	,
cord-001835-0s7ok4uw	1885	11	which	which	WDT
cord-001835-0s7ok4uw	1885	12	functions	function	VBZ
cord-001835-0s7ok4uw	1885	13	as	as	IN
cord-001835-0s7ok4uw	1885	14	an	an	DT
cord-001835-0s7ok4uw	1885	15	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	1885	16	by	by	IN
cord-001835-0s7ok4uw	1885	17	first	first	RB
cord-001835-0s7ok4uw	1885	18	complexing	complexe	VBG
cord-001835-0s7ok4uw	1885	19	with	with	IN
cord-001835-0s7ok4uw	1885	20	the	the	DT
cord-001835-0s7ok4uw	1885	21	peptidyl	peptidyl	NNP
cord-001835-0s7ok4uw	1885	22	-	-	HYPH
cord-001835-0s7ok4uw	1885	23	prolyl	prolyl	NNP
cord-001835-0s7ok4uw	1885	24	cis	cis	NNP
cord-001835-0s7ok4uw	1885	25	-	-	HYPH
cord-001835-0s7ok4uw	1885	26	trans	trans	NNP
cord-001835-0s7ok4uw	1885	27	isomerase	isomerase	NN
cord-001835-0s7ok4uw	1885	28	immunophilin	immunophilin	NNP
cord-001835-0s7ok4uw	1885	29	,	,	,
cord-001835-0s7ok4uw	1885	30	FKBP12	FKBP12	NNP
cord-001835-0s7ok4uw	1885	31	.	.	.
cord-001835-0s7ok4uw	1886	1	The	the	DT
cord-001835-0s7ok4uw	1886	2	FKBP12-FK506	FKBP12-FK506	NNP
cord-001835-0s7ok4uw	1886	3	complex	complex	NN
cord-001835-0s7ok4uw	1886	4	subsequently	subsequently	RB
cord-001835-0s7ok4uw	1886	5	binds	bind	VBZ
cord-001835-0s7ok4uw	1886	6	to	to	IN
cord-001835-0s7ok4uw	1886	7	calcineurin	calcineurin	VB
cord-001835-0s7ok4uw	1886	8	in	in	IN
cord-001835-0s7ok4uw	1886	9	a	a	DT
cord-001835-0s7ok4uw	1886	10	groove	groove	NN
cord-001835-0s7ok4uw	1886	11	between	between	IN
cord-001835-0s7ok4uw	1886	12	the	the	DT
cord-001835-0s7ok4uw	1886	13	A	a	NN
cord-001835-0s7ok4uw	1886	14	and	and	CC
cord-001835-0s7ok4uw	1886	15	B	b	NN
cord-001835-0s7ok4uw	1886	16	subunits	subunit	NNS
cord-001835-0s7ok4uw	1886	17	and	and	CC
cord-001835-0s7ok4uw	1886	18	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	1886	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1886	20	activity	activity	NN
cord-001835-0s7ok4uw	1886	21	.	.	.
cord-001835-0s7ok4uw	1887	1	Although	although	IN
cord-001835-0s7ok4uw	1887	2	fungal	fungal	JJ
cord-001835-0s7ok4uw	1887	3	calcineurins	calcineurin	NNS
cord-001835-0s7ok4uw	1887	4	are	be	VBP
cord-001835-0s7ok4uw	1887	5	targeted	target	VBN
cord-001835-0s7ok4uw	1887	6	by	by	IN
cord-001835-0s7ok4uw	1887	7	FK506	FK506	NNP
cord-001835-0s7ok4uw	1887	8	,	,	,
cord-001835-0s7ok4uw	1887	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	1887	10	also	also	RB
cord-001835-0s7ok4uw	1887	11	targets	target	VBZ
cord-001835-0s7ok4uw	1887	12	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	1887	13	calcineurin	calcineurin	NN
cord-001835-0s7ok4uw	1887	14	and	and	CC
cord-001835-0s7ok4uw	1887	15	is	be	VBZ
cord-001835-0s7ok4uw	1887	16	thus	thus	RB
cord-001835-0s7ok4uw	1887	17	immunosuppressive	immunosuppressive	JJ
cord-001835-0s7ok4uw	1887	18	in	in	IN
cord-001835-0s7ok4uw	1887	19	the	the	DT
cord-001835-0s7ok4uw	1887	20	host	host	NN
cord-001835-0s7ok4uw	1887	21	.	.	.
cord-001835-0s7ok4uw	1888	1	In	in	IN
cord-001835-0s7ok4uw	1888	2	order	order	NN
cord-001835-0s7ok4uw	1888	3	to	to	TO
cord-001835-0s7ok4uw	1888	4	improve	improve	VB
cord-001835-0s7ok4uw	1888	5	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	1888	6	efficacy	efficacy	NN
cord-001835-0s7ok4uw	1888	7	,	,	,
cord-001835-0s7ok4uw	1888	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	1888	9	have	have	VBP
cord-001835-0s7ok4uw	1888	10	undertaken	undertake	VBN
cord-001835-0s7ok4uw	1888	11	a	a	DT
cord-001835-0s7ok4uw	1888	12	unique	unique	JJ
cord-001835-0s7ok4uw	1888	13	effort	effort	NN
cord-001835-0s7ok4uw	1888	14	that	that	WDT
cord-001835-0s7ok4uw	1888	15	utilizes	utilize	VBZ
cord-001835-0s7ok4uw	1888	16	both	both	DT
cord-001835-0s7ok4uw	1888	17	structural	structural	JJ
cord-001835-0s7ok4uw	1888	18	biology	biology	NN
cord-001835-0s7ok4uw	1888	19	and	and	CC
cord-001835-0s7ok4uw	1888	20	molecular	molecular	JJ
cord-001835-0s7ok4uw	1888	21	mycology	mycology	NN
cord-001835-0s7ok4uw	1888	22	in	in	IN
cord-001835-0s7ok4uw	1888	23	an	an	DT
cord-001835-0s7ok4uw	1888	24	effort	effort	NN
cord-001835-0s7ok4uw	1888	25	to	to	TO
cord-001835-0s7ok4uw	1888	26	overcome	overcome	VB
cord-001835-0s7ok4uw	1888	27	the	the	DT
cord-001835-0s7ok4uw	1888	28	fungal	fungal	NN
cord-001835-0s7ok4uw	1888	29	versus	versus	IN
cord-001835-0s7ok4uw	1888	30	human	human	JJ
cord-001835-0s7ok4uw	1888	31	specificity	specificity	NN
cord-001835-0s7ok4uw	1888	32	barrier	barrier	NN
cord-001835-0s7ok4uw	1888	33	.	.	.
cord-001835-0s7ok4uw	1889	1	The	the	DT
cord-001835-0s7ok4uw	1889	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	1889	3	studies	study	NNS
cord-001835-0s7ok4uw	1889	4	to	to	TO
cord-001835-0s7ok4uw	1889	5	be	be	VB
cord-001835-0s7ok4uw	1889	6	presented	present	VBN
cord-001835-0s7ok4uw	1889	7	here	here	RB
cord-001835-0s7ok4uw	1889	8	have	have	VBP
cord-001835-0s7ok4uw	1889	9	been	be	VBN
cord-001835-0s7ok4uw	1889	10	focused	focus	VBN
cord-001835-0s7ok4uw	1889	11	on	on	IN
cord-001835-0s7ok4uw	1889	12	determining	determine	VBG
cord-001835-0s7ok4uw	1889	13	the	the	DT
cord-001835-0s7ok4uw	1889	14	resonance	resonance	NN
cord-001835-0s7ok4uw	1889	15	assignments	assignment	NNS
cord-001835-0s7ok4uw	1889	16	and	and	CC
cord-001835-0s7ok4uw	1889	17	solution	solution	NN
cord-001835-0s7ok4uw	1889	18	structures	structure	NNS
cord-001835-0s7ok4uw	1889	19	for	for	IN
cord-001835-0s7ok4uw	1889	20	the	the	DT
cord-001835-0s7ok4uw	1889	21	FKBP12	FKBP12	NNP
cord-001835-0s7ok4uw	1889	22	proteins	protein	NNS
cord-001835-0s7ok4uw	1889	23	from	from	IN
cord-001835-0s7ok4uw	1889	24	the	the	DT
cord-001835-0s7ok4uw	1889	25	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	1889	26	fungi	fungus	NNS
cord-001835-0s7ok4uw	1889	27	Candida	candida	NN
cord-001835-0s7ok4uw	1889	28	albicans	albican	NNS
cord-001835-0s7ok4uw	1889	29	,	,	,
cord-001835-0s7ok4uw	1889	30	Candida	Candida	NNP
cord-001835-0s7ok4uw	1889	31	glabrata	glabrata	NN
cord-001835-0s7ok4uw	1889	32	and	and	CC
cord-001835-0s7ok4uw	1889	33	Aspergillus	aspergillus	NN
cord-001835-0s7ok4uw	1889	34	fumigatus	fumigatus	NN
cord-001835-0s7ok4uw	1889	35	.	.	.
cord-001835-0s7ok4uw	1890	1	Notably	notably	RB
cord-001835-0s7ok4uw	1890	2	,	,	,
cord-001835-0s7ok4uw	1890	3	the	the	DT
cord-001835-0s7ok4uw	1890	4	X	x	NN
cord-001835-0s7ok4uw	1890	5	-	-	NN
cord-001835-0s7ok4uw	1890	6	ray	ray	NN
cord-001835-0s7ok4uw	1890	7	crystallography	crystallography	NN
cord-001835-0s7ok4uw	1890	8	structures	structure	NNS
cord-001835-0s7ok4uw	1890	9	of	of	IN
cord-001835-0s7ok4uw	1890	10	the	the	DT
cord-001835-0s7ok4uw	1890	11	wild	wild	JJ
cord-001835-0s7ok4uw	1890	12	-	-	HYPH
cord-001835-0s7ok4uw	1890	13	type	type	NN
cord-001835-0s7ok4uw	1890	14	Candida	Candida	NNP
cord-001835-0s7ok4uw	1890	15	albicans	albican	NNS
cord-001835-0s7ok4uw	1890	16	and	and	CC
cord-001835-0s7ok4uw	1890	17	Aspergillus	aspergillus	NN
cord-001835-0s7ok4uw	1890	18	fumigatus	fumigatus	NN
cord-001835-0s7ok4uw	1890	19	FKBP12	FKBP12	NNP
cord-001835-0s7ok4uw	1890	20	proteins	protein	NNS
cord-001835-0s7ok4uw	1890	21	revealed	reveal	VBD
cord-001835-0s7ok4uw	1890	22	an	an	DT
cord-001835-0s7ok4uw	1890	23	intriguing	intriguing	JJ
cord-001835-0s7ok4uw	1890	24	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	1890	25	interaction	interaction	NN
cord-001835-0s7ok4uw	1890	26	involving	involve	VBG
cord-001835-0s7ok4uw	1890	27	four	four	CD
cord-001835-0s7ok4uw	1890	28	residues	residue	NNS
cord-001835-0s7ok4uw	1890	29	in	in	IN
cord-001835-0s7ok4uw	1890	30	the	the	DT
cord-001835-0s7ok4uw	1890	31	80	80	CD
cord-001835-0s7ok4uw	1890	32	's	's	POS
cord-001835-0s7ok4uw	1890	33	loop	loop	NN
cord-001835-0s7ok4uw	1890	34	including	include	VBG
cord-001835-0s7ok4uw	1890	35	Pro104	pro104	NN
cord-001835-0s7ok4uw	1890	36	(	(	-LRB-
cord-001835-0s7ok4uw	1890	37	in	in	IN
cord-001835-0s7ok4uw	1890	38	C.	C.	NNP
cord-001835-0s7ok4uw	1890	39	albicans	albican	NNS
cord-001835-0s7ok4uw	1890	40	)	)	-RRB-
cord-001835-0s7ok4uw	1890	41	and	and	CC
cord-001835-0s7ok4uw	1890	42	Pro90	Pro90	NNP
cord-001835-0s7ok4uw	1890	43	(	(	-LRB-
cord-001835-0s7ok4uw	1890	44	in	in	IN
cord-001835-0s7ok4uw	1890	45	A.	a.	NN
cord-001835-0s7ok4uw	1890	46	fumigatus	fumigatus	NN
cord-001835-0s7ok4uw	1890	47	)	)	-RRB-
cord-001835-0s7ok4uw	1890	48	which	which	WDT
cord-001835-0s7ok4uw	1890	49	are	be	VBP
cord-001835-0s7ok4uw	1890	50	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	1890	51	in	in	IN
cord-001835-0s7ok4uw	1890	52	the	the	DT
cord-001835-0s7ok4uw	1890	53	cis	cis	NNP
cord-001835-0s7ok4uw	1890	54	conformation	conformation	NN
cord-001835-0s7ok4uw	1890	55	.	.	.
cord-001835-0s7ok4uw	1891	1	These	these	DT
cord-001835-0s7ok4uw	1891	2	data	datum	NNS
cord-001835-0s7ok4uw	1891	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	1891	4	that	that	IN
cord-001835-0s7ok4uw	1891	5	the	the	DT
cord-001835-0s7ok4uw	1891	6	protein	protein	NN
cord-001835-0s7ok4uw	1891	7	might	may	MD
cord-001835-0s7ok4uw	1891	8	use	use	VB
cord-001835-0s7ok4uw	1891	9	itself	-PRON-	PRP
cord-001835-0s7ok4uw	1891	10	as	as	IN
cord-001835-0s7ok4uw	1891	11	an	an	DT
cord-001835-0s7ok4uw	1891	12	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1891	13	substrate	substrate	NN
cord-001835-0s7ok4uw	1891	14	.	.	.
cord-001835-0s7ok4uw	1892	1	In	in	IN
cord-001835-0s7ok4uw	1892	2	efforts	effort	NNS
cord-001835-0s7ok4uw	1892	3	to	to	TO
cord-001835-0s7ok4uw	1892	4	establish	establish	VB
cord-001835-0s7ok4uw	1892	5	if	if	IN
cord-001835-0s7ok4uw	1892	6	this	this	DT
cord-001835-0s7ok4uw	1892	7	interaction	interaction	NN
cord-001835-0s7ok4uw	1892	8	remains	remain	VBZ
cord-001835-0s7ok4uw	1892	9	in	in	IN
cord-001835-0s7ok4uw	1892	10	a	a	DT
cord-001835-0s7ok4uw	1892	11	solution	solution	NN
cord-001835-0s7ok4uw	1892	12	environment	environment	NN
cord-001835-0s7ok4uw	1892	13	,	,	,
cord-001835-0s7ok4uw	1892	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	1892	15	have	have	VBP
cord-001835-0s7ok4uw	1892	16	determined	determine	VBN
cord-001835-0s7ok4uw	1892	17	the	the	DT
cord-001835-0s7ok4uw	1892	18	NMR	NMR	NNP
cord-001835-0s7ok4uw	1892	19	structure	structure	NN
cord-001835-0s7ok4uw	1892	20	and	and	CC
cord-001835-0s7ok4uw	1892	21	measured	measure	VBD
cord-001835-0s7ok4uw	1892	22	the	the	DT
cord-001835-0s7ok4uw	1892	23	T2	T2	NNP
cord-001835-0s7ok4uw	1892	24	relaxation	relaxation	NN
cord-001835-0s7ok4uw	1892	25	rates	rate	NNS
cord-001835-0s7ok4uw	1892	26	for	for	IN
cord-001835-0s7ok4uw	1892	27	the	the	DT
cord-001835-0s7ok4uw	1892	28	wild	wild	JJ
cord-001835-0s7ok4uw	1892	29	-	-	HYPH
cord-001835-0s7ok4uw	1892	30	type	type	NN
cord-001835-0s7ok4uw	1892	31	A.	a.	NN
cord-001835-0s7ok4uw	1892	32	fumigatus	fumigatus	NN
cord-001835-0s7ok4uw	1892	33	FKBP12	FKBP12	NNP
cord-001835-0s7ok4uw	1892	34	protein	protein	NN
cord-001835-0s7ok4uw	1892	35	and	and	CC
cord-001835-0s7ok4uw	1892	36	for	for	IN
cord-001835-0s7ok4uw	1892	37	the	the	DT
cord-001835-0s7ok4uw	1892	38	P90	P90	NNP
cord-001835-0s7ok4uw	1892	39	G	G	NNP
cord-001835-0s7ok4uw	1892	40	mutant	mutant	NN
cord-001835-0s7ok4uw	1892	41	variant	variant	NN
cord-001835-0s7ok4uw	1892	42	that	that	WDT
cord-001835-0s7ok4uw	1892	43	adopts	adopt	VBZ
cord-001835-0s7ok4uw	1892	44	a	a	DT
cord-001835-0s7ok4uw	1892	45	dramatically	dramatically	RB
cord-001835-0s7ok4uw	1892	46	different	different	JJ
cord-001835-0s7ok4uw	1892	47	orientation	orientation	NN
cord-001835-0s7ok4uw	1892	48	of	of	IN
cord-001835-0s7ok4uw	1892	49	the	the	DT
cord-001835-0s7ok4uw	1892	50	80	80	CD
cord-001835-0s7ok4uw	1892	51	's	's	POS
cord-001835-0s7ok4uw	1892	52	loop	loop	NN
cord-001835-0s7ok4uw	1892	53	and	and	CC
cord-001835-0s7ok4uw	1892	54	does	do	VBZ
cord-001835-0s7ok4uw	1892	55	not	not	RB
cord-001835-0s7ok4uw	1892	56	form	form	VB
cord-001835-0s7ok4uw	1892	57	an	an	DT
cord-001835-0s7ok4uw	1892	58	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	1892	59	interaction	interaction	NN
cord-001835-0s7ok4uw	1892	60	in	in	IN
cord-001835-0s7ok4uw	1892	61	the	the	DT
cord-001835-0s7ok4uw	1892	62	crystal	crystal	NN
cord-001835-0s7ok4uw	1892	63	structure	structure	NN
cord-001835-0s7ok4uw	1892	64	.	.	.
cord-001835-0s7ok4uw	1893	1	The	the	DT
cord-001835-0s7ok4uw	1893	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	1893	3	chemical	chemical	NN
cord-001835-0s7ok4uw	1893	4	shift	shift	NN
cord-001835-0s7ok4uw	1893	5	data	datum	NNS
cord-001835-0s7ok4uw	1893	6	indicate	indicate	VBP
cord-001835-0s7ok4uw	1893	7	that	that	IN
cord-001835-0s7ok4uw	1893	8	,	,	,
cord-001835-0s7ok4uw	1893	9	while	while	IN
cord-001835-0s7ok4uw	1893	10	the	the	DT
cord-001835-0s7ok4uw	1893	11	remainder	remainder	NN
cord-001835-0s7ok4uw	1893	12	of	of	IN
cord-001835-0s7ok4uw	1893	13	the	the	DT
cord-001835-0s7ok4uw	1893	14	protein	protein	NN
cord-001835-0s7ok4uw	1893	15	structure	structure	NN
cord-001835-0s7ok4uw	1893	16	remains	remain	VBZ
cord-001835-0s7ok4uw	1893	17	unchanged	unchanged	JJ
cord-001835-0s7ok4uw	1893	18	,	,	,
cord-001835-0s7ok4uw	1893	19	the	the	DT
cord-001835-0s7ok4uw	1893	20	80	80	CD
cord-001835-0s7ok4uw	1893	21	's	's	POS
cord-001835-0s7ok4uw	1893	22	loops	loop	NNS
cord-001835-0s7ok4uw	1893	23	in	in	IN
cord-001835-0s7ok4uw	1893	24	the	the	DT
cord-001835-0s7ok4uw	1893	25	two	two	CD
cord-001835-0s7ok4uw	1893	26	variants	variant	NNS
cord-001835-0s7ok4uw	1893	27	are	be	VBP
cord-001835-0s7ok4uw	1893	28	indeed	indeed	RB
cord-001835-0s7ok4uw	1893	29	different	different	JJ
cord-001835-0s7ok4uw	1893	30	.	.	.
cord-001835-0s7ok4uw	1894	1	In	in	IN
cord-001835-0s7ok4uw	1894	2	addition	addition	NN
cord-001835-0s7ok4uw	1894	3	,	,	,
cord-001835-0s7ok4uw	1894	4	the	the	DT
cord-001835-0s7ok4uw	1894	5	T2	T2	NNP
cord-001835-0s7ok4uw	1894	6	relaxation	relaxation	NN
cord-001835-0s7ok4uw	1894	7	rates	rate	NNS
cord-001835-0s7ok4uw	1894	8	of	of	IN
cord-001835-0s7ok4uw	1894	9	the	the	DT
cord-001835-0s7ok4uw	1894	10	residues	residue	NNS
cord-001835-0s7ok4uw	1894	11	in	in	IN
cord-001835-0s7ok4uw	1894	12	this	this	DT
cord-001835-0s7ok4uw	1894	13	region	region	NN
cord-001835-0s7ok4uw	1894	14	are	be	VBP
cord-001835-0s7ok4uw	1894	15	dramatically	dramatically	RB
cord-001835-0s7ok4uw	1894	16	dissimilar	dissimilar	JJ
cord-001835-0s7ok4uw	1894	17	in	in	IN
cord-001835-0s7ok4uw	1894	18	the	the	DT
cord-001835-0s7ok4uw	1894	19	two	two	CD
cord-001835-0s7ok4uw	1894	20	variants	variant	NNS
cord-001835-0s7ok4uw	1894	21	,	,	,
cord-001835-0s7ok4uw	1894	22	but	but	CC
cord-001835-0s7ok4uw	1894	23	remain	remain	VBP
cord-001835-0s7ok4uw	1894	24	identical	identical	JJ
cord-001835-0s7ok4uw	1894	25	throughout	throughout	IN
cord-001835-0s7ok4uw	1894	26	the	the	DT
cord-001835-0s7ok4uw	1894	27	rest	rest	NN
cord-001835-0s7ok4uw	1894	28	of	of	IN
cord-001835-0s7ok4uw	1894	29	the	the	DT
cord-001835-0s7ok4uw	1894	30	protein	protein	NN
cord-001835-0s7ok4uw	1894	31	.	.	.
cord-001835-0s7ok4uw	1895	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1895	2	have	have	VBP
cord-001835-0s7ok4uw	1895	3	also	also	RB
cord-001835-0s7ok4uw	1895	4	begun	begin	VBN
cord-001835-0s7ok4uw	1895	5	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	1895	6	binding	bind	VBG
cord-001835-0s7ok4uw	1895	7	studies	study	NNS
cord-001835-0s7ok4uw	1895	8	of	of	IN
cord-001835-0s7ok4uw	1895	9	all	all	DT
cord-001835-0s7ok4uw	1895	10	of	of	IN
cord-001835-0s7ok4uw	1895	11	the	the	DT
cord-001835-0s7ok4uw	1895	12	FKBP12	FKBP12	NNP
cord-001835-0s7ok4uw	1895	13	proteins	protein	NNS
cord-001835-0s7ok4uw	1895	14	from	from	IN
cord-001835-0s7ok4uw	1895	15	each	each	DT
cord-001835-0s7ok4uw	1895	16	of	of	IN
cord-001835-0s7ok4uw	1895	17	the	the	DT
cord-001835-0s7ok4uw	1895	18	pathogens	pathogen	NNS
cord-001835-0s7ok4uw	1895	19	by	by	IN
cord-001835-0s7ok4uw	1895	20	titrating	titrate	VBG
cord-001835-0s7ok4uw	1895	21	the	the	DT
cord-001835-0s7ok4uw	1895	22	FK506	fk506	JJ
cord-001835-0s7ok4uw	1895	23	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	1895	24	into	into	IN
cord-001835-0s7ok4uw	1895	25	native	native	JJ
cord-001835-0s7ok4uw	1895	26	and	and	CC
cord-001835-0s7ok4uw	1895	27	mutant	mutant	JJ
cord-001835-0s7ok4uw	1895	28	FKBP12	FKBP12	NNP
cord-001835-0s7ok4uw	1895	29	proteins	protein	NNS
cord-001835-0s7ok4uw	1895	30	in	in	IN
cord-001835-0s7ok4uw	1895	31	order	order	NN
cord-001835-0s7ok4uw	1895	32	to	to	TO
cord-001835-0s7ok4uw	1895	33	examine	examine	VB
cord-001835-0s7ok4uw	1895	34	conformational	conformational	JJ
cord-001835-0s7ok4uw	1895	35	changes	change	NNS
cord-001835-0s7ok4uw	1895	36	associated	associate	VBN
cord-001835-0s7ok4uw	1895	37	in	in	IN
cord-001835-0s7ok4uw	1895	38	the	the	DT
cord-001835-0s7ok4uw	1895	39	protein	protein	NN
cord-001835-0s7ok4uw	1895	40	upon	upon	IN
cord-001835-0s7ok4uw	1895	41	complex	complex	JJ
cord-001835-0s7ok4uw	1895	42	formation	formation	NN
cord-001835-0s7ok4uw	1895	43	.	.	.
cord-001835-0s7ok4uw	1896	1	Using	use	VBG
cord-001835-0s7ok4uw	1896	2	this	this	DT
cord-001835-0s7ok4uw	1896	3	approach	approach	NN
cord-001835-0s7ok4uw	1896	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	1896	5	plan	plan	VBP
cord-001835-0s7ok4uw	1896	6	to	to	TO
cord-001835-0s7ok4uw	1896	7	determine	determine	VB
cord-001835-0s7ok4uw	1896	8	the	the	DT
cord-001835-0s7ok4uw	1896	9	relative	relative	JJ
cord-001835-0s7ok4uw	1896	10	Kd	Kd	NNP
cord-001835-0s7ok4uw	1896	11	values	value	NNS
cord-001835-0s7ok4uw	1896	12	for	for	IN
cord-001835-0s7ok4uw	1896	13	binding	bind	VBG
cord-001835-0s7ok4uw	1896	14	of	of	IN
cord-001835-0s7ok4uw	1896	15	each	each	DT
cord-001835-0s7ok4uw	1896	16	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	1896	17	to	to	IN
cord-001835-0s7ok4uw	1896	18	the	the	DT
cord-001835-0s7ok4uw	1896	19	FKBP12	FKBP12	NNP
cord-001835-0s7ok4uw	1896	20	protein	protein	NN
cord-001835-0s7ok4uw	1896	21	from	from	IN
cord-001835-0s7ok4uw	1896	22	each	each	DT
cord-001835-0s7ok4uw	1896	23	pathogen	pathogen	NN
cord-001835-0s7ok4uw	1896	24	for	for	IN
cord-001835-0s7ok4uw	1896	25	comparison	comparison	NN
cord-001835-0s7ok4uw	1896	26	of	of	IN
cord-001835-0s7ok4uw	1896	27	binding	bind	VBG
cord-001835-0s7ok4uw	1896	28	proclivities	proclivity	NNS
cord-001835-0s7ok4uw	1896	29	.	.	.
cord-001835-0s7ok4uw	1897	1	Lupin	Lupin	NNP
cord-001835-0s7ok4uw	1897	2	(	(	-LRB-
cord-001835-0s7ok4uw	1897	3	Lupinus	Lupinus	NNP
cord-001835-0s7ok4uw	1897	4	angustifolius	angustifolius	NN
cord-001835-0s7ok4uw	1897	5	L.	L.	NNP
cord-001835-0s7ok4uw	1897	6	)	)	-RRB-
cord-001835-0s7ok4uw	1897	7	b	b	NNP
cord-001835-0s7ok4uw	1897	8	-	-	:
cord-001835-0s7ok4uw	1897	9	conglutin	conglutin	NNP
cord-001835-0s7ok4uw	1897	10	proteins	protein	NNS
cord-001835-0s7ok4uw	1897	11	:	:	:
cord-001835-0s7ok4uw	1898	1	Structure	structure	NN
cord-001835-0s7ok4uw	1898	2	functional	functional	JJ
cord-001835-0s7ok4uw	1898	3	features	feature	NNS
cord-001835-0s7ok4uw	1898	4	,	,	,
cord-001835-0s7ok4uw	1898	5	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1898	6	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1898	7	modeling	modeling	NN
cord-001835-0s7ok4uw	1898	8	and	and	CC
cord-001835-0s7ok4uw	1898	9	cross	cross	NN
cord-001835-0s7ok4uw	1898	10	-	-	JJ
cord-001835-0s7ok4uw	1898	11	allergenicity	allergenicity	JJ
cord-001835-0s7ok4uw	1898	12	identification	identification	NN
cord-001835-0s7ok4uw	1898	13	using	use	VBG
cord-001835-0s7ok4uw	1898	14	protein	protein	NN
cord-001835-0s7ok4uw	1898	15	threading	threading	NN
cord-001835-0s7ok4uw	1898	16	and	and	CC
cord-001835-0s7ok4uw	1898	17	molecular	molecular	JJ
cord-001835-0s7ok4uw	1898	18	docking	docking	NN
cord-001835-0s7ok4uw	1898	19	methods	method	NNS
cord-001835-0s7ok4uw	1899	1	Lupin	Lupin	NNP
cord-001835-0s7ok4uw	1899	2	is	be	VBZ
cord-001835-0s7ok4uw	1899	3	an	an	DT
cord-001835-0s7ok4uw	1899	4	important	important	JJ
cord-001835-0s7ok4uw	1899	5	PULSE	pulse	NN
cord-001835-0s7ok4uw	1899	6	,	,	,
cord-001835-0s7ok4uw	1899	7	which	which	WDT
cord-001835-0s7ok4uw	1899	8	displays	display	VBZ
cord-001835-0s7ok4uw	1899	9	a	a	DT
cord-001835-0s7ok4uw	1899	10	wide	wide	JJ
cord-001835-0s7ok4uw	1899	11	range	range	NN
cord-001835-0s7ok4uw	1899	12	of	of	IN
cord-001835-0s7ok4uw	1899	13	benefits	benefit	NNS
cord-001835-0s7ok4uw	1899	14	in	in	IN
cord-001835-0s7ok4uw	1899	15	agriculture	agriculture	NN
cord-001835-0s7ok4uw	1899	16	,	,	,
cord-001835-0s7ok4uw	1899	17	particularly	particularly	RB
cord-001835-0s7ok4uw	1899	18	these	these	DT
cord-001835-0s7ok4uw	1899	19	involved	involve	VBN
cord-001835-0s7ok4uw	1899	20	in	in	IN
cord-001835-0s7ok4uw	1899	21	possible	possible	JJ
cord-001835-0s7ok4uw	1899	22	plant	plant	NN
cord-001835-0s7ok4uw	1899	23	pathogen	pathogen	NN
cord-001835-0s7ok4uw	1899	24	suppression	suppression	NN
cord-001835-0s7ok4uw	1899	25	.	.	.
cord-001835-0s7ok4uw	1900	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1900	2	,	,	,
cord-001835-0s7ok4uw	1900	3	lupin	lupin	NNP
cord-001835-0s7ok4uw	1900	4	seed	seed	NN
cord-001835-0s7ok4uw	1900	5	proteins	protein	NNS
cord-001835-0s7ok4uw	1900	6	promote	promote	VBP
cord-001835-0s7ok4uw	1900	7	different	different	JJ
cord-001835-0s7ok4uw	1900	8	positive	positive	JJ
cord-001835-0s7ok4uw	1900	9	health	health	NN
cord-001835-0s7ok4uw	1900	10	aspects	aspect	NNS
cord-001835-0s7ok4uw	1900	11	,	,	,
cord-001835-0s7ok4uw	1900	12	preventing	prevent	VBG
cord-001835-0s7ok4uw	1900	13	cardiovascular	cardiovascular	JJ
cord-001835-0s7ok4uw	1900	14	disease	disease	NN
cord-001835-0s7ok4uw	1900	15	,	,	,
cord-001835-0s7ok4uw	1900	16	and	and	CC
cord-001835-0s7ok4uw	1900	17	reduction	reduction	NN
cord-001835-0s7ok4uw	1900	18	of	of	IN
cord-001835-0s7ok4uw	1900	19	glucose	glucose	NN
cord-001835-0s7ok4uw	1900	20	and	and	CC
cord-001835-0s7ok4uw	1900	21	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	1900	22	blood	blood	NN
cord-001835-0s7ok4uw	1900	23	levels	level	NNS
cord-001835-0s7ok4uw	1900	24	.	.	.
cord-001835-0s7ok4uw	1901	1	"	"	''
cord-001835-0s7ok4uw	1902	1	Sweet	sweet	JJ
cord-001835-0s7ok4uw	1902	2	lupine	lupine	NN
cord-001835-0s7ok4uw	1902	3	"	"	''
cord-001835-0s7ok4uw	1902	4	seeds	seed	NNS
cord-001835-0s7ok4uw	1902	5	seem	seem	VBP
cord-001835-0s7ok4uw	1902	6	to	to	TO
cord-001835-0s7ok4uw	1902	7	be	be	VB
cord-001835-0s7ok4uw	1902	8	promising	promising	JJ
cord-001835-0s7ok4uw	1902	9	as	as	IN
cord-001835-0s7ok4uw	1902	10	a	a	DT
cord-001835-0s7ok4uw	1902	11	source	source	NN
cord-001835-0s7ok4uw	1902	12	of	of	IN
cord-001835-0s7ok4uw	1902	13	innovative	innovative	JJ
cord-001835-0s7ok4uw	1902	14	food	food	NN
cord-001835-0s7ok4uw	1902	15	ingredients	ingredient	NNS
cord-001835-0s7ok4uw	1902	16	due	due	JJ
cord-001835-0s7ok4uw	1902	17	to	to	IN
cord-001835-0s7ok4uw	1902	18	averaged	average	VBN
cord-001835-0s7ok4uw	1902	19	protein	protein	NN
cord-001835-0s7ok4uw	1902	20	content	content	NN
cord-001835-0s7ok4uw	1902	21	similar	similar	JJ
cord-001835-0s7ok4uw	1902	22	to	to	IN
cord-001835-0s7ok4uw	1902	23	soybean	soybean	NN
cord-001835-0s7ok4uw	1902	24	and	and	CC
cord-001835-0s7ok4uw	1902	25	an	an	DT
cord-001835-0s7ok4uw	1902	26	adequate	adequate	JJ
cord-001835-0s7ok4uw	1902	27	composition	composition	NN
cord-001835-0s7ok4uw	1902	28	of	of	IN
cord-001835-0s7ok4uw	1902	29	essential	essential	JJ
cord-001835-0s7ok4uw	1902	30	amino	amino	JJ
cord-001835-0s7ok4uw	1902	31	acids	acid	NNS
cord-001835-0s7ok4uw	1902	32	.	.	.
cord-001835-0s7ok4uw	1903	1	Thus	thus	RB
cord-001835-0s7ok4uw	1903	2	,	,	,
cord-001835-0s7ok4uw	1903	3	lupin	lupin	NNP
cord-001835-0s7ok4uw	1903	4	seeds	seed	NNS
cord-001835-0s7ok4uw	1903	5	may	may	MD
cord-001835-0s7ok4uw	1903	6	be	be	VB
cord-001835-0s7ok4uw	1903	7	important	important	JJ
cord-001835-0s7ok4uw	1903	8	source	source	NN
cord-001835-0s7ok4uw	1903	9	of	of	IN
cord-001835-0s7ok4uw	1903	10	proteins	protein	NNS
cord-001835-0s7ok4uw	1903	11	for	for	IN
cord-001835-0s7ok4uw	1903	12	human	human	JJ
cord-001835-0s7ok4uw	1903	13	and	and	CC
cord-001835-0s7ok4uw	1903	14	animal	animal	NN
cord-001835-0s7ok4uw	1903	15	consumption	consumption	NN
cord-001835-0s7ok4uw	1903	16	.	.	.
cord-001835-0s7ok4uw	1904	1	However	however	RB
cord-001835-0s7ok4uw	1904	2	,	,	,
cord-001835-0s7ok4uw	1904	3	and	and	CC
cord-001835-0s7ok4uw	1904	4	as	as	IN
cord-001835-0s7ok4uw	1904	5	drawback	drawback	NN
cord-001835-0s7ok4uw	1904	6	feature	feature	NN
cord-001835-0s7ok4uw	1904	7	,	,	,
cord-001835-0s7ok4uw	1904	8	the	the	DT
cord-001835-0s7ok4uw	1904	9	number	number	NN
cord-001835-0s7ok4uw	1904	10	of	of	IN
cord-001835-0s7ok4uw	1904	11	allergic	allergic	JJ
cord-001835-0s7ok4uw	1904	12	people	people	NNS
cord-001835-0s7ok4uw	1904	13	to	to	IN
cord-001835-0s7ok4uw	1904	14	lupin	lupin	NNP
cord-001835-0s7ok4uw	1904	15	seed	seed	NN
cord-001835-0s7ok4uw	1904	16	proteins	protein	NNS
cord-001835-0s7ok4uw	1904	17	is	be	VBZ
cord-001835-0s7ok4uw	1904	18	rising	rise	VBG
cord-001835-0s7ok4uw	1904	19	,	,	,
cord-001835-0s7ok4uw	1904	20	becoming	become	VBG
cord-001835-0s7ok4uw	1904	21	a	a	DT
cord-001835-0s7ok4uw	1904	22	serious	serious	JJ
cord-001835-0s7ok4uw	1904	23	and	and	CC
cord-001835-0s7ok4uw	1904	24	a	a	DT
cord-001835-0s7ok4uw	1904	25	growing	grow	VBG
cord-001835-0s7ok4uw	1904	26	problem	problem	NN
cord-001835-0s7ok4uw	1904	27	in	in	IN
cord-001835-0s7ok4uw	1904	28	the	the	DT
cord-001835-0s7ok4uw	1904	29	Western	western	JJ
cord-001835-0s7ok4uw	1904	30	world	world	NN
cord-001835-0s7ok4uw	1904	31	,	,	,
cord-001835-0s7ok4uw	1904	32	because	because	IN
cord-001835-0s7ok4uw	1904	33	of	of	IN
cord-001835-0s7ok4uw	1904	34	the	the	DT
cord-001835-0s7ok4uw	1904	35	rapid	rapid	JJ
cord-001835-0s7ok4uw	1904	36	introduction	introduction	NN
cord-001835-0s7ok4uw	1904	37	of	of	IN
cord-001835-0s7ok4uw	1904	38	lupin	lupin	NNP
cord-001835-0s7ok4uw	1904	39	seeds	seed	NNS
cord-001835-0s7ok4uw	1904	40	as	as	IN
cord-001835-0s7ok4uw	1904	41	new	new	JJ
cord-001835-0s7ok4uw	1904	42	ingredients	ingredient	NNS
cord-001835-0s7ok4uw	1904	43	in	in	IN
cord-001835-0s7ok4uw	1904	44	traditional	traditional	JJ
cord-001835-0s7ok4uw	1904	45	and	and	CC
cord-001835-0s7ok4uw	1904	46	novel	novel	JJ
cord-001835-0s7ok4uw	1904	47	foods	food	NNS
cord-001835-0s7ok4uw	1904	48	.	.	.
cord-001835-0s7ok4uw	1905	1	The	the	DT
cord-001835-0s7ok4uw	1905	2	goals	goal	NNS
cord-001835-0s7ok4uw	1905	3	of	of	IN
cord-001835-0s7ok4uw	1905	4	this	this	DT
cord-001835-0s7ok4uw	1905	5	study	study	NN
cord-001835-0s7ok4uw	1905	6	are	be	VBP
cord-001835-0s7ok4uw	1905	7	the	the	DT
cord-001835-0s7ok4uw	1905	8	characterization	characterization	NN
cord-001835-0s7ok4uw	1905	9	the	the	DT
cord-001835-0s7ok4uw	1905	10	structure	structure	NN
cord-001835-0s7ok4uw	1905	11	-	-	HYPH
cord-001835-0s7ok4uw	1905	12	functional	functional	JJ
cord-001835-0s7ok4uw	1905	13	properties	property	NNS
cord-001835-0s7ok4uw	1905	14	of	of	IN
cord-001835-0s7ok4uw	1905	15	Lupinus	Lupinus	NNP
cord-001835-0s7ok4uw	1905	16	angustifolius	angustifolius	NN
cord-001835-0s7ok4uw	1905	17	L	L	NNP
cord-001835-0s7ok4uw	1905	18	or	or	CC
cord-001835-0s7ok4uw	1905	19	Narrow	Narrow	NNP
cord-001835-0s7ok4uw	1905	20	leafed	leafed	JJ
cord-001835-0s7ok4uw	1905	21	lupin	lupin	NN
cord-001835-0s7ok4uw	1905	22	(	(	-LRB-
cord-001835-0s7ok4uw	1905	23	NLL	NLL	NNP
cord-001835-0s7ok4uw	1905	24	)	)	-RRB-
cord-001835-0s7ok4uw	1905	25	b	b	NNP
cord-001835-0s7ok4uw	1905	26	-	-	:
cord-001835-0s7ok4uw	1905	27	conglutin	conglutin	NNP
cord-001835-0s7ok4uw	1905	28	proteins	protein	NNS
cord-001835-0s7ok4uw	1905	29	,	,	,
cord-001835-0s7ok4uw	1905	30	with	with	IN
cord-001835-0s7ok4uw	1905	31	a	a	DT
cord-001835-0s7ok4uw	1905	32	focus	focus	NN
cord-001835-0s7ok4uw	1905	33	in	in	IN
cord-001835-0s7ok4uw	1905	34	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1905	35	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1905	36	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1905	37	,	,	,
cord-001835-0s7ok4uw	1905	38	and	and	CC
cord-001835-0s7ok4uw	1905	39	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1905	40	molecular	molecular	JJ
cord-001835-0s7ok4uw	1905	41	cross	cross	NN
cord-001835-0s7ok4uw	1905	42	-	-	NN
cord-001835-0s7ok4uw	1905	43	allergenicity	allergenicity	NN
cord-001835-0s7ok4uw	1905	44	with	with	IN
cord-001835-0s7ok4uw	1905	45	other	other	JJ
cord-001835-0s7ok4uw	1905	46	legumes	legume	NNS
cord-001835-0s7ok4uw	1905	47	,	,	,
cord-001835-0s7ok4uw	1905	48	i.e.	i.e.	FW
cord-001835-0s7ok4uw	1905	49	peanut	peanut	NN
cord-001835-0s7ok4uw	1905	50	,	,	,
cord-001835-0s7ok4uw	1905	51	by	by	IN
cord-001835-0s7ok4uw	1905	52	extensive	extensive	JJ
cord-001835-0s7ok4uw	1905	53	analysis	analysis	NN
cord-001835-0s7ok4uw	1905	54	using	use	VBG
cord-001835-0s7ok4uw	1905	55	different	different	JJ
cord-001835-0s7ok4uw	1905	56	computer	computer	NN
cord-001835-0s7ok4uw	1905	57	-	-	HYPH
cord-001835-0s7ok4uw	1905	58	aided	aid	VBN
cord-001835-0s7ok4uw	1905	59	molecular	molecular	JJ
cord-001835-0s7ok4uw	1905	60	approaches	approach	NNS
cord-001835-0s7ok4uw	1905	61	covering	cover	VBG
cord-001835-0s7ok4uw	1905	62	(	(	-LRB-
cord-001835-0s7ok4uw	1905	63	i	i	NN
cord-001835-0s7ok4uw	1905	64	)	)	-RRB-
cord-001835-0s7ok4uw	1905	65	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	1905	66	properties	property	NNS
cord-001835-0s7ok4uw	1905	67	and	and	CC
cord-001835-0s7ok4uw	1905	68	functional	functional	JJ
cord-001835-0s7ok4uw	1905	69	-	-	HYPH
cord-001835-0s7ok4uw	1905	70	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	1905	71	motifs	motif	NNS
cord-001835-0s7ok4uw	1905	72	,	,	,
cord-001835-0s7ok4uw	1905	73	(	(	-LRB-
cord-001835-0s7ok4uw	1905	74	ii	ii	NN
cord-001835-0s7ok4uw	1905	75	)	)	-RRB-
cord-001835-0s7ok4uw	1905	76	sequence	sequence	NN
cord-001835-0s7ok4uw	1905	77	analysis	analysis	NN
cord-001835-0s7ok4uw	1905	78	,	,	,
cord-001835-0s7ok4uw	1905	79	2-D	2-D	NNP
cord-001835-0s7ok4uw	1905	80	and	and	CC
cord-001835-0s7ok4uw	1905	81	3D	3d	JJ
cord-001835-0s7ok4uw	1905	82	structural	structural	JJ
cord-001835-0s7ok4uw	1905	83	(	(	-LRB-
cord-001835-0s7ok4uw	1905	84	threading	threading	NN
cord-001835-0s7ok4uw	1905	85	)	)	-RRB-
cord-001835-0s7ok4uw	1905	86	modeling	model	VBG
cord-001835-0s7ok4uw	1905	87	comparative	comparative	JJ
cord-001835-0s7ok4uw	1905	88	study	study	NN
cord-001835-0s7ok4uw	1905	89	and	and	CC
cord-001835-0s7ok4uw	1905	90	molecular	molecular	JJ
cord-001835-0s7ok4uw	1905	91	docking	docking	NN
cord-001835-0s7ok4uw	1905	92	,	,	,
cord-001835-0s7ok4uw	1905	93	(	(	-LRB-
cord-001835-0s7ok4uw	1905	94	iii	iii	NN
cord-001835-0s7ok4uw	1905	95	)	)	-RRB-
cord-001835-0s7ok4uw	1905	96	conservational	conservational	JJ
cord-001835-0s7ok4uw	1905	97	and	and	CC
cord-001835-0s7ok4uw	1905	98	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	1905	99	analysis	analysis	NN
cord-001835-0s7ok4uw	1905	100	,	,	,
cord-001835-0s7ok4uw	1905	101	(	(	-LRB-
cord-001835-0s7ok4uw	1905	102	iv	iv	LS
cord-001835-0s7ok4uw	1905	103	)	)	-RRB-
cord-001835-0s7ok4uw	1905	104	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	1905	105	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1905	106	modeling	modeling	NN
cord-001835-0s7ok4uw	1905	107	,	,	,
cord-001835-0s7ok4uw	1905	108	and	and	CC
cord-001835-0s7ok4uw	1905	109	(	(	-LRB-
cord-001835-0s7ok4uw	1905	110	v	v	NN
cord-001835-0s7ok4uw	1905	111	)	)	-RRB-
cord-001835-0s7ok4uw	1905	112	sequence	sequence	NN
cord-001835-0s7ok4uw	1905	113	,	,	,
cord-001835-0s7ok4uw	1905	114	structure	structure	NN
cord-001835-0s7ok4uw	1905	115	-	-	HYPH
cord-001835-0s7ok4uw	1905	116	docking	docking	NN
cord-001835-0s7ok4uw	1906	1	based	base	VBN
cord-001835-0s7ok4uw	1906	2	b	b	NN
cord-001835-0s7ok4uw	1906	3	-	-	HYPH
cord-001835-0s7ok4uw	1906	4	cell	cell	NN
cord-001835-0s7ok4uw	1906	5	epitopes	epitope	NNS
cord-001835-0s7ok4uw	1906	6	prediction	prediction	NN
cord-001835-0s7ok4uw	1906	7	,	,	,
cord-001835-0s7ok4uw	1906	8	while	while	IN
cord-001835-0s7ok4uw	1906	9	T	t	NN
cord-001835-0s7ok4uw	1906	10	-	-	HYPH
cord-001835-0s7ok4uw	1906	11	cell	cell	NN
cord-001835-0s7ok4uw	1906	12	epitopes	epitope	NNS
cord-001835-0s7ok4uw	1906	13	were	be	VBD
cord-001835-0s7ok4uw	1906	14	predicted	predict	VBN
cord-001835-0s7ok4uw	1906	15	by	by	IN
cord-001835-0s7ok4uw	1906	16	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	1906	17	concentration	concentration	NN
cord-001835-0s7ok4uw	1906	18	and	and	CC
cord-001835-0s7ok4uw	1906	19	binding	binding	NN
cord-001835-0s7ok4uw	1906	20	score	score	NN
cord-001835-0s7ok4uw	1906	21	methods	method	NNS
cord-001835-0s7ok4uw	1906	22	.	.	.
cord-001835-0s7ok4uw	1907	1	b	b	LS
cord-001835-0s7ok4uw	1907	2	-	-	:
cord-001835-0s7ok4uw	1907	3	conglutins	conglutins	NNP
cord-001835-0s7ok4uw	1907	4	(	(	-LRB-
cord-001835-0s7ok4uw	1907	5	vicilin	vicilin	JJ
cord-001835-0s7ok4uw	1907	6	-	-	HYPH
cord-001835-0s7ok4uw	1907	7	like	like	JJ
cord-001835-0s7ok4uw	1907	8	or	or	CC
cord-001835-0s7ok4uw	1907	9	7S	7s	JJ
cord-001835-0s7ok4uw	1907	10	proteins	protein	NNS
cord-001835-0s7ok4uw	1907	11	)	)	-RRB-
cord-001835-0s7ok4uw	1907	12	are	be	VBP
cord-001835-0s7ok4uw	1907	13	seed	seed	NN
cord-001835-0s7ok4uw	1907	14	proteins	protein	NNS
cord-001835-0s7ok4uw	1907	15	typically	typically	RB
cord-001835-0s7ok4uw	1907	16	found	find	VBN
cord-001835-0s7ok4uw	1907	17	in	in	IN
cord-001835-0s7ok4uw	1907	18	reserve	reserve	NN
cord-001835-0s7ok4uw	1907	19	tissues	tissue	NNS
cord-001835-0s7ok4uw	1907	20	(	(	-LRB-
cord-001835-0s7ok4uw	1907	21	endosperm	endosperm	NN
cord-001835-0s7ok4uw	1907	22	and	and	CC
cord-001835-0s7ok4uw	1907	23	cotyledon	cotyledon	NN
cord-001835-0s7ok4uw	1907	24	)	)	-RRB-
cord-001835-0s7ok4uw	1907	25	.	.	.
cord-001835-0s7ok4uw	1908	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	1908	2	belong	belong	VBP
cord-001835-0s7ok4uw	1908	3	to	to	IN
cord-001835-0s7ok4uw	1908	4	the	the	DT
cord-001835-0s7ok4uw	1908	5	Cupin	Cupin	NNP
cord-001835-0s7ok4uw	1908	6	superfamily	superfamily	NN
cord-001835-0s7ok4uw	1908	7	of	of	IN
cord-001835-0s7ok4uw	1908	8	proteins	protein	NNS
cord-001835-0s7ok4uw	1908	9	,	,	,
cord-001835-0s7ok4uw	1908	10	containing	contain	VBG
cord-001835-0s7ok4uw	1908	11	a	a	DT
cord-001835-0s7ok4uw	1908	12	globular	globular	JJ
cord-001835-0s7ok4uw	1908	13	domain	domain	NN
cord-001835-0s7ok4uw	1908	14	constituted	constitute	VBN
cord-001835-0s7ok4uw	1908	15	by	by	IN
cord-001835-0s7ok4uw	1908	16	a	a	DT
cord-001835-0s7ok4uw	1908	17	conserved	conserve	VBN
cord-001835-0s7ok4uw	1908	18	b	b	NN
cord-001835-0s7ok4uw	1908	19	-	-	HYPH
cord-001835-0s7ok4uw	1908	20	barrel	barrel	NN
cord-001835-0s7ok4uw	1908	21	.	.	.
cord-001835-0s7ok4uw	1909	1	Two	two	CD
cord-001835-0s7ok4uw	1909	2	barrels	barrel	NNS
cord-001835-0s7ok4uw	1909	3	were	be	VBD
cord-001835-0s7ok4uw	1909	4	found	find	VBN
cord-001835-0s7ok4uw	1909	5	in	in	IN
cord-001835-0s7ok4uw	1909	6	all	all	DT
cord-001835-0s7ok4uw	1909	7	b	b	NN
cord-001835-0s7ok4uw	1909	8	-	-	HYPH
cord-001835-0s7ok4uw	1909	9	conglutin	conglutin	NNP
cord-001835-0s7ok4uw	1909	10	protein	protein	NN
cord-001835-0s7ok4uw	1909	11	isoforms	isoform	NNS
cord-001835-0s7ok4uw	1909	12	and	and	CC
cord-001835-0s7ok4uw	1909	13	an	an	DT
cord-001835-0s7ok4uw	1909	14	additional	additional	JJ
cord-001835-0s7ok4uw	1909	15	mobile	mobile	JJ
cord-001835-0s7ok4uw	1909	16	N	n	CD
cord-001835-0s7ok4uw	1909	17	-	-	HYPH
cord-001835-0s7ok4uw	1909	18	terminal	terminal	JJ
cord-001835-0s7ok4uw	1909	19	arm	arm	NN
cord-001835-0s7ok4uw	1909	20	constituted	constitute	VBD
cord-001835-0s7ok4uw	1909	21	bye	bye	UH
cord-001835-0s7ok4uw	1909	22	a	a	DT
cord-001835-0s7ok4uw	1909	23	-	-	:
cord-001835-0s7ok4uw	1909	24	helices	helix	NNS
cord-001835-0s7ok4uw	1909	25	.	.	.
cord-001835-0s7ok4uw	1910	1	Molecular	molecular	JJ
cord-001835-0s7ok4uw	1910	2	modeling	modeling	NN
cord-001835-0s7ok4uw	1910	3	analysis	analysis	NN
cord-001835-0s7ok4uw	1910	4	has	have	VBZ
cord-001835-0s7ok4uw	1910	5	shown	show	VBN
cord-001835-0s7ok4uw	1910	6	that	that	IN
cord-001835-0s7ok4uw	1910	7	one	one	CD
cord-001835-0s7ok4uw	1910	8	of	of	IN
cord-001835-0s7ok4uw	1910	9	this	this	DT
cord-001835-0s7ok4uw	1910	10	barrel	barrel	NN
cord-001835-0s7ok4uw	1910	11	contain	contain	VBP
cord-001835-0s7ok4uw	1910	12	a	a	DT
cord-001835-0s7ok4uw	1910	13	semi	semi	JJ
cord-001835-0s7ok4uw	1910	14	-	-	JJ
cord-001835-0s7ok4uw	1910	15	conserved	conserved	JJ
cord-001835-0s7ok4uw	1910	16	metal	metal	NN
cord-001835-0s7ok4uw	1910	17	binding	bind	VBG
cord-001835-0s7ok4uw	1910	18	motive	motive	NN
cord-001835-0s7ok4uw	1910	19	(	(	-LRB-
cord-001835-0s7ok4uw	1910	20	HYX	HYX	NNP
cord-001835-0s7ok4uw	1910	21	.	.	.
cord-001835-0s7ok4uw	1910	22	.	.	.
cord-001835-0s7ok4uw	1911	1	.R	.r	LS
cord-001835-0s7ok4uw	1911	2	)	)	-RRB-
cord-001835-0s7ok4uw	1911	3	,	,	,
cord-001835-0s7ok4uw	1911	4	typically	typically	RB
cord-001835-0s7ok4uw	1911	5	found	find	VBN
cord-001835-0s7ok4uw	1911	6	in	in	IN
cord-001835-0s7ok4uw	1911	7	Oxalate	oxalate	NN
cord-001835-0s7ok4uw	1911	8	oxidase	oxidase	NN
cord-001835-0s7ok4uw	1911	9	(	(	-LRB-
cord-001835-0s7ok4uw	1911	10	OXOX	OXOX	NNP
cord-001835-0s7ok4uw	1911	11	)	)	-RRB-
cord-001835-0s7ok4uw	1911	12	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	1911	13	.	.	.
cord-001835-0s7ok4uw	1912	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	1912	2	,	,	,
cord-001835-0s7ok4uw	1912	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1912	4	results	result	NNS
cord-001835-0s7ok4uw	1912	5	revealed	reveal	VBD
cord-001835-0s7ok4uw	1912	6	considerable	considerable	JJ
cord-001835-0s7ok4uw	1912	7	structural	structural	JJ
cord-001835-0s7ok4uw	1912	8	differences	difference	NNS
cord-001835-0s7ok4uw	1912	9	between	between	IN
cord-001835-0s7ok4uw	1912	10	b	b	LS
cord-001835-0s7ok4uw	1912	11	-	-	HYPH
cord-001835-0s7ok4uw	1912	12	conglutin	conglutin	NNP
cord-001835-0s7ok4uw	1912	13	isoforms	isoform	NNS
cord-001835-0s7ok4uw	1912	14	,	,	,
cord-001835-0s7ok4uw	1912	15	particularly	particularly	RB
cord-001835-0s7ok4uw	1912	16	affecting	affect	VBG
cord-001835-0s7ok4uw	1912	17	2-D	2-d	JJ
cord-001835-0s7ok4uw	1912	18	elements	element	NNS
cord-001835-0s7ok4uw	1912	19	(	(	-LRB-
cord-001835-0s7ok4uw	1912	20	loops	loop	NNS
cord-001835-0s7ok4uw	1912	21	and	and	CC
cord-001835-0s7ok4uw	1912	22	coils	coil	NNS
cord-001835-0s7ok4uw	1912	23	)	)	-RRB-
cord-001835-0s7ok4uw	1912	24	,	,	,
cord-001835-0s7ok4uw	1912	25	and	and	CC
cord-001835-0s7ok4uw	1912	26	numerous	numerous	JJ
cord-001835-0s7ok4uw	1912	27	micro	micro	NNS
cord-001835-0s7ok4uw	1912	28	-	-	NNS
cord-001835-0s7ok4uw	1912	29	heterogeneities	heterogeneity	NNS
cord-001835-0s7ok4uw	1912	30	are	be	VBP
cord-001835-0s7ok4uw	1912	31	present	present	JJ
cord-001835-0s7ok4uw	1912	32	in	in	IN
cord-001835-0s7ok4uw	1912	33	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	1912	34	residues	residue	NNS
cord-001835-0s7ok4uw	1912	35	directly	directly	RB
cord-001835-0s7ok4uw	1912	36	involved	involve	VBN
cord-001835-0s7ok4uw	1912	37	in	in	IN
cord-001835-0s7ok4uw	1912	38	epitopes	epitopes	NN
cord-001835-0s7ok4uw	1912	39	variability	variability	NN
cord-001835-0s7ok4uw	1912	40	,	,	,
cord-001835-0s7ok4uw	1912	41	which	which	WDT
cord-001835-0s7ok4uw	1912	42	might	may	MD
cord-001835-0s7ok4uw	1912	43	be	be	VB
cord-001835-0s7ok4uw	1912	44	a	a	DT
cord-001835-0s7ok4uw	1912	45	major	major	JJ
cord-001835-0s7ok4uw	1912	46	contributor	contributor	NN
cord-001835-0s7ok4uw	1912	47	to	to	IN
cord-001835-0s7ok4uw	1912	48	the	the	DT
cord-001835-0s7ok4uw	1912	49	observed	observed	JJ
cord-001835-0s7ok4uw	1912	50	differences	difference	NNS
cord-001835-0s7ok4uw	1912	51	in	in	IN
cord-001835-0s7ok4uw	1912	52	cross	cross	NN
cord-001835-0s7ok4uw	1912	53	-	-	NN
cord-001835-0s7ok4uw	1912	54	reactivity	reactivity	NN
cord-001835-0s7ok4uw	1912	55	among	among	IN
cord-001835-0s7ok4uw	1912	56	legumes	legume	NNS
cord-001835-0s7ok4uw	1912	57	.	.	.
cord-001835-0s7ok4uw	1913	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1913	2	also	also	RB
cord-001835-0s7ok4uw	1913	3	identified	identify	VBD
cord-001835-0s7ok4uw	1913	4	multiple	multiple	JJ
cord-001835-0s7ok4uw	1913	5	forms	form	NNS
cord-001835-0s7ok4uw	1913	6	of	of	IN
cord-001835-0s7ok4uw	1913	7	b	b	NN
cord-001835-0s7ok4uw	1913	8	-	-	HYPH
cord-001835-0s7ok4uw	1913	9	conglutins	conglutin	NNS
cord-001835-0s7ok4uw	1913	10	polypeptides	polypeptide	NNS
cord-001835-0s7ok4uw	1913	11	ranging	range	VBG
cord-001835-0s7ok4uw	1913	12	from	from	IN
cord-001835-0s7ok4uw	1913	13	15	15	CD
cord-001835-0s7ok4uw	1913	14	-	-	HYPH
cord-001835-0s7ok4uw	1913	15	80kDa	80kda	CD
cord-001835-0s7ok4uw	1913	16	,	,	,
cord-001835-0s7ok4uw	1913	17	with	with	IN
cord-001835-0s7ok4uw	1913	18	IgE	ige	NN
cord-001835-0s7ok4uw	1913	19	-	-	HYPH
cord-001835-0s7ok4uw	1913	20	binding	bind	VBG
cord-001835-0s7ok4uw	1913	21	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	1913	22	in	in	IN
cord-001835-0s7ok4uw	1913	23	atopic	atopic	JJ
cord-001835-0s7ok4uw	1913	24	patients	patient	NNS
cord-001835-0s7ok4uw	1913	25	.	.	.
cord-001835-0s7ok4uw	1914	1	Thus	thus	RB
cord-001835-0s7ok4uw	1914	2	,	,	,
cord-001835-0s7ok4uw	1914	3	b	b	NN
cord-001835-0s7ok4uw	1914	4	-	-	HYPH
cord-001835-0s7ok4uw	1914	5	conglutins	conglutin	NNS
cord-001835-0s7ok4uw	1914	6	might	may	MD
cord-001835-0s7ok4uw	1914	7	be	be	VB
cord-001835-0s7ok4uw	1914	8	considered	consider	VBN
cord-001835-0s7ok4uw	1914	9	as	as	IN
cord-001835-0s7ok4uw	1914	10	major	major	JJ
cord-001835-0s7ok4uw	1914	11	allergen	allergen	NN
cord-001835-0s7ok4uw	1914	12	in	in	IN
cord-001835-0s7ok4uw	1914	13	different	different	JJ
cord-001835-0s7ok4uw	1914	14	species	specie	NNS
cord-001835-0s7ok4uw	1914	15	of	of	IN
cord-001835-0s7ok4uw	1914	16	lupin	lupin	NN
cord-001835-0s7ok4uw	1914	17	,	,	,
cord-001835-0s7ok4uw	1914	18	including	include	VBG
cord-001835-0s7ok4uw	1914	19	the	the	DT
cord-001835-0s7ok4uw	1914	20	"	"	``
cord-001835-0s7ok4uw	1914	21	sweet	sweet	JJ
cord-001835-0s7ok4uw	1914	22	lupin	lupin	NNP
cord-001835-0s7ok4uw	1914	23	"	"	''
cord-001835-0s7ok4uw	1914	24	group	group	NN
cord-001835-0s7ok4uw	1914	25	,	,	,
cord-001835-0s7ok4uw	1914	26	since	since	IN
cord-001835-0s7ok4uw	1914	27	several	several	JJ
cord-001835-0s7ok4uw	1914	28	of	of	IN
cord-001835-0s7ok4uw	1914	29	these	these	DT
cord-001835-0s7ok4uw	1914	30	polypeptides	polypeptide	NNS
cord-001835-0s7ok4uw	1914	31	were	be	VBD
cord-001835-0s7ok4uw	1914	32	recognized	recognize	VBN
cord-001835-0s7ok4uw	1914	33	by	by	IN
cord-001835-0s7ok4uw	1914	34	human	human	JJ
cord-001835-0s7ok4uw	1914	35	IgEs	iges	NN
cord-001835-0s7ok4uw	1914	36	,	,	,
cord-001835-0s7ok4uw	1914	37	having	have	VBG
cord-001835-0s7ok4uw	1914	38	the	the	DT
cord-001835-0s7ok4uw	1914	39	potential	potential	NN
cord-001835-0s7ok4uw	1914	40	to	to	TO
cord-001835-0s7ok4uw	1914	41	trigger	trigger	VB
cord-001835-0s7ok4uw	1914	42	an	an	DT
cord-001835-0s7ok4uw	1914	43	immune	immune	JJ
cord-001835-0s7ok4uw	1914	44	response	response	NN
cord-001835-0s7ok4uw	1914	45	leading	lead	VBG
cord-001835-0s7ok4uw	1914	46	to	to	IN
cord-001835-0s7ok4uw	1914	47	allergy	allergy	NN
cord-001835-0s7ok4uw	1914	48	symptoms	symptom	NNS
cord-001835-0s7ok4uw	1914	49	.	.	.
cord-001835-0s7ok4uw	1915	1	1	1	CD
cord-001835-0s7ok4uw	1915	2	 	 	_SP
cord-001835-0s7ok4uw	1916	1	Influenza	influenza	NN
cord-001835-0s7ok4uw	1916	2	virus	virus	NN
cord-001835-0s7ok4uw	1916	3	is	be	VBZ
cord-001835-0s7ok4uw	1916	4	one	one	CD
cord-001835-0s7ok4uw	1916	5	of	of	IN
cord-001835-0s7ok4uw	1916	6	the	the	DT
cord-001835-0s7ok4uw	1916	7	most	most	RBS
cord-001835-0s7ok4uw	1916	8	prevalent	prevalent	JJ
cord-001835-0s7ok4uw	1916	9	pathogens	pathogen	NNS
cord-001835-0s7ok4uw	1916	10	causing	cause	VBG
cord-001835-0s7ok4uw	1916	11	respiratory	respiratory	JJ
cord-001835-0s7ok4uw	1916	12	illness	illness	NN
cord-001835-0s7ok4uw	1916	13	which	which	WDT
cord-001835-0s7ok4uw	1916	14	often	often	RB
cord-001835-0s7ok4uw	1916	15	leads	lead	VBZ
cord-001835-0s7ok4uw	1916	16	to	to	IN
cord-001835-0s7ok4uw	1916	17	serious	serious	JJ
cord-001835-0s7ok4uw	1916	18	post	post	NN
cord-001835-0s7ok4uw	1916	19	influenza	influenza	NN
cord-001835-0s7ok4uw	1916	20	complications	complication	NNS
cord-001835-0s7ok4uw	1916	21	such	such	JJ
cord-001835-0s7ok4uw	1916	22	as	as	IN
cord-001835-0s7ok4uw	1916	23	pneumonia	pneumonia	NN
cord-001835-0s7ok4uw	1916	24	and	and	CC
cord-001835-0s7ok4uw	1916	25	myocarditis	myocarditis	NN
cord-001835-0s7ok4uw	1916	26	.	.	.
cord-001835-0s7ok4uw	1917	1	Some	some	DT
cord-001835-0s7ok4uw	1917	2	viruses	virus	NNS
cord-001835-0s7ok4uw	1917	3	,	,	,
cord-001835-0s7ok4uw	1917	4	as	as	IN
cord-001835-0s7ok4uw	1917	5	the	the	DT
cord-001835-0s7ok4uw	1917	6	avian	avian	JJ
cord-001835-0s7ok4uw	1917	7	influenza	influenza	NN
cord-001835-0s7ok4uw	1917	8	H5N1	H5N1	NNP
cord-001835-0s7ok4uw	1917	9	,	,	,
cord-001835-0s7ok4uw	1917	10	are	be	VBP
cord-001835-0s7ok4uw	1917	11	especially	especially	RB
cord-001835-0s7ok4uw	1917	12	dangerous	dangerous	JJ
cord-001835-0s7ok4uw	1917	13	and	and	CC
cord-001835-0s7ok4uw	1917	14	draw	draw	VB
cord-001835-0s7ok4uw	1917	15	special	special	JJ
cord-001835-0s7ok4uw	1917	16	attention	attention	NN
cord-001835-0s7ok4uw	1917	17	of	of	IN
cord-001835-0s7ok4uw	1917	18	WHO	WHO	NNP
cord-001835-0s7ok4uw	1917	19	.	.	.
cord-001835-0s7ok4uw	1918	1	This	this	DT
cord-001835-0s7ok4uw	1918	2	highly	highly	RB
cord-001835-0s7ok4uw	1918	3	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	1918	4	virus	virus	NN
cord-001835-0s7ok4uw	1918	5	spreads	spread	VBZ
cord-001835-0s7ok4uw	1918	6	quickly	quickly	RB
cord-001835-0s7ok4uw	1918	7	among	among	IN
cord-001835-0s7ok4uw	1918	8	domestic	domestic	JJ
cord-001835-0s7ok4uw	1918	9	poultry	poultry	NN
cord-001835-0s7ok4uw	1918	10	and	and	CC
cord-001835-0s7ok4uw	1918	11	wild	wild	JJ
cord-001835-0s7ok4uw	1918	12	birds	bird	NNS
cord-001835-0s7ok4uw	1918	13	resulting	result	VBG
cord-001835-0s7ok4uw	1918	14	in	in	IN
cord-001835-0s7ok4uw	1918	15	high	high	JJ
cord-001835-0s7ok4uw	1918	16	mortality	mortality	NN
cord-001835-0s7ok4uw	1918	17	.	.	.
cord-001835-0s7ok4uw	1919	1	What	what	WP
cord-001835-0s7ok4uw	1919	2	is	be	VBZ
cord-001835-0s7ok4uw	1919	3	more	more	RBR
cord-001835-0s7ok4uw	1919	4	distressing	distressing	JJ
cord-001835-0s7ok4uw	1919	5	,	,	,
cord-001835-0s7ok4uw	1919	6	the	the	DT
cord-001835-0s7ok4uw	1919	7	H5N1	H5N1	NNP
cord-001835-0s7ok4uw	1919	8	virus	virus	NN
cord-001835-0s7ok4uw	1919	9	may	may	MD
cord-001835-0s7ok4uw	1919	10	be	be	VB
cord-001835-0s7ok4uw	1919	11	transmitted	transmit	VBN
cord-001835-0s7ok4uw	1919	12	to	to	IN
cord-001835-0s7ok4uw	1919	13	humans	human	NNS
cord-001835-0s7ok4uw	1919	14	.	.	.
cord-001835-0s7ok4uw	1920	1	Because	because	IN
cord-001835-0s7ok4uw	1920	2	of	of	IN
cord-001835-0s7ok4uw	1920	3	antigenic	antigenic	JJ
cord-001835-0s7ok4uw	1920	4	drift	drift	NN
cord-001835-0s7ok4uw	1920	5	it	-PRON-	PRP
cord-001835-0s7ok4uw	1920	6	is	be	VBZ
cord-001835-0s7ok4uw	1920	7	impossible	impossible	JJ
cord-001835-0s7ok4uw	1920	8	to	to	TO
cord-001835-0s7ok4uw	1920	9	deliver	deliver	VB
cord-001835-0s7ok4uw	1920	10	an	an	DT
cord-001835-0s7ok4uw	1920	11	effective	effective	JJ
cord-001835-0s7ok4uw	1920	12	vaccine	vaccine	NN
cord-001835-0s7ok4uw	1920	13	against	against	IN
cord-001835-0s7ok4uw	1920	14	all	all	DT
cord-001835-0s7ok4uw	1920	15	subtypes	subtype	NNS
cord-001835-0s7ok4uw	1920	16	of	of	IN
cord-001835-0s7ok4uw	1920	17	the	the	DT
cord-001835-0s7ok4uw	1920	18	H5N1	H5N1	NNP
cord-001835-0s7ok4uw	1920	19	virus	virus	NN
cord-001835-0s7ok4uw	1920	20	.	.	.
cord-001835-0s7ok4uw	1921	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	1921	2	,	,	,
cord-001835-0s7ok4uw	1921	3	traditional	traditional	JJ
cord-001835-0s7ok4uw	1921	4	egg	egg	NN
cord-001835-0s7ok4uw	1921	5	-	-	HYPH
cord-001835-0s7ok4uw	1921	6	based	base	VBN
cord-001835-0s7ok4uw	1921	7	production	production	NN
cord-001835-0s7ok4uw	1921	8	of	of	IN
cord-001835-0s7ok4uw	1921	9	influenza	influenza	NN
cord-001835-0s7ok4uw	1921	10	vaccines	vaccine	NNS
cord-001835-0s7ok4uw	1921	11	is	be	VBZ
cord-001835-0s7ok4uw	1921	12	time	time	NN
cord-001835-0s7ok4uw	1921	13	-	-	HYPH
cord-001835-0s7ok4uw	1921	14	and	and	CC
cord-001835-0s7ok4uw	1921	15	cost	cost	NN
cord-001835-0s7ok4uw	1921	16	-	-	HYPH
cord-001835-0s7ok4uw	1921	17	consuming	consume	VBG
cord-001835-0s7ok4uw	1921	18	,	,	,
cord-001835-0s7ok4uw	1921	19	what	what	WP
cord-001835-0s7ok4uw	1921	20	makes	make	VBZ
cord-001835-0s7ok4uw	1921	21	it	-PRON-	PRP
cord-001835-0s7ok4uw	1921	22	inadequate	inadequate	JJ
cord-001835-0s7ok4uw	1921	23	in	in	IN
cord-001835-0s7ok4uw	1921	24	case	case	NN
cord-001835-0s7ok4uw	1921	25	of	of	IN
cord-001835-0s7ok4uw	1921	26	a	a	DT
cord-001835-0s7ok4uw	1921	27	pandemic	pandemic	NN
cord-001835-0s7ok4uw	1921	28	.	.	.
cord-001835-0s7ok4uw	1922	1	Hence	hence	RB
cord-001835-0s7ok4uw	1922	2	,	,	,
cord-001835-0s7ok4uw	1922	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1922	4	have	have	VBP
cord-001835-0s7ok4uw	1922	5	developed	develop	VBN
cord-001835-0s7ok4uw	1922	6	an	an	DT
cord-001835-0s7ok4uw	1922	7	efficient	efficient	JJ
cord-001835-0s7ok4uw	1922	8	production	production	NN
cord-001835-0s7ok4uw	1922	9	process	process	NN
cord-001835-0s7ok4uw	1922	10	of	of	IN
cord-001835-0s7ok4uw	1922	11	influenza	influenza	NN
cord-001835-0s7ok4uw	1922	12	vaccine	vaccine	NN
cord-001835-0s7ok4uw	1922	13	based	base	VBN
cord-001835-0s7ok4uw	1922	14	on	on	IN
cord-001835-0s7ok4uw	1922	15	a	a	DT
cord-001835-0s7ok4uw	1922	16	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1922	17	hemagglutinin	hemagglutinin	NN
cord-001835-0s7ok4uw	1922	18	antigen	antigen	NN
cord-001835-0s7ok4uw	1922	19	(	(	-LRB-
cord-001835-0s7ok4uw	1922	20	rHA	rHA	NNP
cord-001835-0s7ok4uw	1922	21	)	)	-RRB-
cord-001835-0s7ok4uw	1922	22	.	.	.
cord-001835-0s7ok4uw	1923	1	Recombinant	recombinant	JJ
cord-001835-0s7ok4uw	1923	2	vaccines	vaccine	NNS
cord-001835-0s7ok4uw	1923	3	underlay	underlay	VBP
cord-001835-0s7ok4uw	1923	4	strict	strict	JJ
cord-001835-0s7ok4uw	1923	5	regulations	regulation	NNS
cord-001835-0s7ok4uw	1923	6	and	and	CC
cord-001835-0s7ok4uw	1923	7	quality	quality	NN
cord-001835-0s7ok4uw	1923	8	requirements	requirement	NNS
cord-001835-0s7ok4uw	1923	9	.	.	.
cord-001835-0s7ok4uw	1924	1	The	the	DT
cord-001835-0s7ok4uw	1924	2	purpose	purpose	NN
cord-001835-0s7ok4uw	1924	3	of	of	IN
cord-001835-0s7ok4uw	1924	4	this	this	DT
cord-001835-0s7ok4uw	1924	5	work	work	NN
cord-001835-0s7ok4uw	1924	6	was	be	VBD
cord-001835-0s7ok4uw	1924	7	to	to	TO
cord-001835-0s7ok4uw	1924	8	develop	develop	VB
cord-001835-0s7ok4uw	1924	9	a	a	DT
cord-001835-0s7ok4uw	1924	10	battery	battery	NN
cord-001835-0s7ok4uw	1924	11	of	of	IN
cord-001835-0s7ok4uw	1924	12	analytical	analytical	JJ
cord-001835-0s7ok4uw	1924	13	methods	method	NNS
cord-001835-0s7ok4uw	1924	14	that	that	WDT
cord-001835-0s7ok4uw	1924	15	allow	allow	VBP
cord-001835-0s7ok4uw	1924	16	to	to	TO
cord-001835-0s7ok4uw	1924	17	evaluate	evaluate	VB
cord-001835-0s7ok4uw	1924	18	key	key	JJ
cord-001835-0s7ok4uw	1924	19	quality	quality	NN
cord-001835-0s7ok4uw	1924	20	attributes	attribute	NNS
cord-001835-0s7ok4uw	1924	21	of	of	IN
cord-001835-0s7ok4uw	1924	22	rHA	rHA	NNS
cord-001835-0s7ok4uw	1924	23	on	on	IN
cord-001835-0s7ok4uw	1924	24	each	each	DT
cord-001835-0s7ok4uw	1924	25	stage	stage	NN
cord-001835-0s7ok4uw	1924	26	of	of	IN
cord-001835-0s7ok4uw	1924	27	production	production	NN
cord-001835-0s7ok4uw	1924	28	.	.	.
cord-001835-0s7ok4uw	1925	1	At	at	IN
cord-001835-0s7ok4uw	1925	2	first	first	RB
cord-001835-0s7ok4uw	1925	3	,	,	,
cord-001835-0s7ok4uw	1925	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	1925	5	have	have	VBP
cord-001835-0s7ok4uw	1925	6	focused	focus	VBN
cord-001835-0s7ok4uw	1925	7	on	on	IN
cord-001835-0s7ok4uw	1925	8	rHA	rHA	NNP
cord-001835-0s7ok4uw	1925	9	structure	structure	NN
cord-001835-0s7ok4uw	1925	10	as	as	IN
cord-001835-0s7ok4uw	1925	11	a	a	DT
cord-001835-0s7ok4uw	1925	12	crucial	crucial	JJ
cord-001835-0s7ok4uw	1925	13	issue	issue	NN
cord-001835-0s7ok4uw	1925	14	for	for	IN
cord-001835-0s7ok4uw	1925	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1925	16	activity	activity	NN
cord-001835-0s7ok4uw	1925	17	.	.	.
cord-001835-0s7ok4uw	1926	1	The	the	DT
cord-001835-0s7ok4uw	1926	2	primary	primary	JJ
cord-001835-0s7ok4uw	1926	3	structure	structure	NN
cord-001835-0s7ok4uw	1926	4	of	of	IN
cord-001835-0s7ok4uw	1926	5	rHA	rHA	NNP
cord-001835-0s7ok4uw	1926	6	was	be	VBD
cord-001835-0s7ok4uw	1926	7	confirmed	confirm	VBN
cord-001835-0s7ok4uw	1926	8	by	by	IN
cord-001835-0s7ok4uw	1926	9	peptide	peptide	NN
cord-001835-0s7ok4uw	1926	10	mapping	mapping	NN
cord-001835-0s7ok4uw	1926	11	and	and	CC
cord-001835-0s7ok4uw	1926	12	TOF	TOF	NNP
cord-001835-0s7ok4uw	1926	13	/	/	SYM
cord-001835-0s7ok4uw	1926	14	TOF	TOF	NNP
cord-001835-0s7ok4uw	1926	15	fragmentation	fragmentation	NN
cord-001835-0s7ok4uw	1926	16	(	(	-LRB-
cord-001835-0s7ok4uw	1926	17	HPLC	HPLC	NNP
cord-001835-0s7ok4uw	1926	18	,	,	,
cord-001835-0s7ok4uw	1926	19	MALDI	MALDI	NNP
cord-001835-0s7ok4uw	1926	20	TOF	TOF	NNP
cord-001835-0s7ok4uw	1926	21	/	/	SYM
cord-001835-0s7ok4uw	1926	22	TOF	TOF	NNP
cord-001835-0s7ok4uw	1926	23	)	)	-RRB-
cord-001835-0s7ok4uw	1926	24	.	.	.
cord-001835-0s7ok4uw	1927	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	1927	2	,	,	,
cord-001835-0s7ok4uw	1927	3	FTIR	FTIR	NNP
cord-001835-0s7ok4uw	1927	4	analysis	analysis	NN
cord-001835-0s7ok4uw	1927	5	was	be	VBD
cord-001835-0s7ok4uw	1927	6	used	use	VBN
cord-001835-0s7ok4uw	1927	7	to	to	TO
cord-001835-0s7ok4uw	1927	8	evaluate	evaluate	VB
cord-001835-0s7ok4uw	1927	9	the	the	DT
cord-001835-0s7ok4uw	1927	10	secondary	secondary	JJ
cord-001835-0s7ok4uw	1927	11	structure	structure	NN
cord-001835-0s7ok4uw	1927	12	of	of	IN
cord-001835-0s7ok4uw	1927	13	the	the	DT
cord-001835-0s7ok4uw	1927	14	protein	protein	NN
cord-001835-0s7ok4uw	1927	15	.	.	.
cord-001835-0s7ok4uw	1928	1	The	the	DT
cord-001835-0s7ok4uw	1928	2	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	1928	3	bonds	bond	NNS
cord-001835-0s7ok4uw	1928	4	,	,	,
cord-001835-0s7ok4uw	1928	5	which	which	WDT
cord-001835-0s7ok4uw	1928	6	stabilize	stabilize	VBP
cord-001835-0s7ok4uw	1928	7	the	the	DT
cord-001835-0s7ok4uw	1928	8	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	1928	9	structure	structure	NN
cord-001835-0s7ok4uw	1928	10	,	,	,
cord-001835-0s7ok4uw	1928	11	were	be	VBD
cord-001835-0s7ok4uw	1928	12	assigned	assign	VBN
cord-001835-0s7ok4uw	1928	13	by	by	IN
cord-001835-0s7ok4uw	1928	14	peptide	peptide	NN
cord-001835-0s7ok4uw	1928	15	mapping	mapping	NN
cord-001835-0s7ok4uw	1928	16	.	.	.
cord-001835-0s7ok4uw	1929	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	1929	2	,	,	,
cord-001835-0s7ok4uw	1929	3	free	free	JJ
cord-001835-0s7ok4uw	1929	4	thiols	thiol	NNS
cord-001835-0s7ok4uw	1929	5	were	be	VBD
cord-001835-0s7ok4uw	1929	6	measured	measure	VBN
cord-001835-0s7ok4uw	1929	7	using	use	VBG
cord-001835-0s7ok4uw	1929	8	Ellman	Ellman	NNP
cord-001835-0s7ok4uw	1929	9	's	's	POS
cord-001835-0s7ok4uw	1929	10	reagent	reagent	NN
cord-001835-0s7ok4uw	1929	11	.	.	.
cord-001835-0s7ok4uw	1930	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	1930	2	,	,	,
cord-001835-0s7ok4uw	1930	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1930	4	have	have	VBP
cord-001835-0s7ok4uw	1930	5	employed	employ	VBN
cord-001835-0s7ok4uw	1930	6	RP	rp	NN
cord-001835-0s7ok4uw	1930	7	-	-	HYPH
cord-001835-0s7ok4uw	1930	8	HPLC	HPLC	NNP
cord-001835-0s7ok4uw	1930	9	,	,	,
cord-001835-0s7ok4uw	1930	10	SEC	SEC	NNP
cord-001835-0s7ok4uw	1930	11	-	-	HYPH
cord-001835-0s7ok4uw	1930	12	MALS	MALS	NNP
cord-001835-0s7ok4uw	1930	13	and	and	CC
cord-001835-0s7ok4uw	1930	14	DLS	DLS	NNP
cord-001835-0s7ok4uw	1930	15	to	to	TO
cord-001835-0s7ok4uw	1930	16	explore	explore	VB
cord-001835-0s7ok4uw	1930	17	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	1930	18	of	of	IN
cord-001835-0s7ok4uw	1930	19	rHA	rHA	NNP
cord-001835-0s7ok4uw	1930	20	.	.	.
cord-001835-0s7ok4uw	1931	1	These	these	DT
cord-001835-0s7ok4uw	1931	2	techniques	technique	NNS
cord-001835-0s7ok4uw	1931	3	appeared	appear	VBD
cord-001835-0s7ok4uw	1931	4	to	to	TO
cord-001835-0s7ok4uw	1931	5	be	be	VB
cord-001835-0s7ok4uw	1931	6	useful	useful	JJ
cord-001835-0s7ok4uw	1931	7	not	not	RB
cord-001835-0s7ok4uw	1931	8	only	only	RB
cord-001835-0s7ok4uw	1931	9	to	to	TO
cord-001835-0s7ok4uw	1931	10	confirm	confirm	VB
cord-001835-0s7ok4uw	1931	11	existence	existence	NN
cord-001835-0s7ok4uw	1931	12	of	of	IN
cord-001835-0s7ok4uw	1931	13	native	native	JJ
cord-001835-0s7ok4uw	1931	14	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	1931	15	,	,	,
cord-001835-0s7ok4uw	1931	16	but	but	CC
cord-001835-0s7ok4uw	1931	17	also	also	RB
cord-001835-0s7ok4uw	1931	18	to	to	TO
cord-001835-0s7ok4uw	1931	19	find	find	VB
cord-001835-0s7ok4uw	1931	20	and	and	CC
cord-001835-0s7ok4uw	1931	21	discard	discard	VB
cord-001835-0s7ok4uw	1931	22	misfolded	misfolde	VBN
cord-001835-0s7ok4uw	1931	23	fraction	fraction	NN
cord-001835-0s7ok4uw	1931	24	,	,	,
cord-001835-0s7ok4uw	1931	25	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	1931	26	and	and	CC
cord-001835-0s7ok4uw	1931	27	truncated	truncated	JJ
cord-001835-0s7ok4uw	1931	28	forms	form	NNS
cord-001835-0s7ok4uw	1931	29	.	.	.
cord-001835-0s7ok4uw	1932	1	In	in	IN
cord-001835-0s7ok4uw	1932	2	addition	addition	NN
cord-001835-0s7ok4uw	1932	3	,	,	,
cord-001835-0s7ok4uw	1932	4	two	two	CD
cord-001835-0s7ok4uw	1932	5	analytical	analytical	JJ
cord-001835-0s7ok4uw	1932	6	methods	method	NNS
cord-001835-0s7ok4uw	1932	7	(	(	-LRB-
cord-001835-0s7ok4uw	1932	8	RP	RP	NNP
cord-001835-0s7ok4uw	1932	9	-	-	HYPH
cord-001835-0s7ok4uw	1932	10	HPLC	HPLC	NNP
cord-001835-0s7ok4uw	1932	11	and	and	CC
cord-001835-0s7ok4uw	1932	12	CGE	CGE	NNP
cord-001835-0s7ok4uw	1932	13	)	)	-RRB-
cord-001835-0s7ok4uw	1932	14	were	be	VBD
cord-001835-0s7ok4uw	1932	15	developed	develop	VBN
cord-001835-0s7ok4uw	1932	16	to	to	TO
cord-001835-0s7ok4uw	1932	17	assess	assess	VB
cord-001835-0s7ok4uw	1932	18	the	the	DT
cord-001835-0s7ok4uw	1932	19	purity	purity	NN
cord-001835-0s7ok4uw	1932	20	of	of	IN
cord-001835-0s7ok4uw	1932	21	rHA	rHA	NNP
cord-001835-0s7ok4uw	1932	22	as	as	IN
cord-001835-0s7ok4uw	1932	23	required	require	VBN
cord-001835-0s7ok4uw	1932	24	by	by	IN
cord-001835-0s7ok4uw	1932	25	ICH	ICH	NNP
cord-001835-0s7ok4uw	1932	26	guidelines	guideline	NNS
cord-001835-0s7ok4uw	1932	27	.	.	.
cord-001835-0s7ok4uw	1933	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1933	2	also	also	RB
cord-001835-0s7ok4uw	1933	3	have	have	VBP
cord-001835-0s7ok4uw	1933	4	determined	determine	VBN
cord-001835-0s7ok4uw	1933	5	isoelectric	isoelectric	JJ
cord-001835-0s7ok4uw	1933	6	point	point	NN
cord-001835-0s7ok4uw	1933	7	and	and	CC
cord-001835-0s7ok4uw	1933	8	heterogeneity	heterogeneity	NN
cord-001835-0s7ok4uw	1933	9	of	of	IN
cord-001835-0s7ok4uw	1933	10	rHA	rHA	NNS
cord-001835-0s7ok4uw	1933	11	by	by	IN
cord-001835-0s7ok4uw	1933	12	cIEF	cIEF	NNS
cord-001835-0s7ok4uw	1933	13	.	.	.
cord-001835-0s7ok4uw	1934	1	Afterward	afterward	RB
cord-001835-0s7ok4uw	1934	2	,	,	,
cord-001835-0s7ok4uw	1934	3	developed	develop	VBN
cord-001835-0s7ok4uw	1934	4	methods	method	NNS
cord-001835-0s7ok4uw	1934	5	were	be	VBD
cord-001835-0s7ok4uw	1934	6	applied	apply	VBN
cord-001835-0s7ok4uw	1934	7	in	in	IN
cord-001835-0s7ok4uw	1934	8	the	the	DT
cord-001835-0s7ok4uw	1934	9	stability	stability	NN
cord-001835-0s7ok4uw	1934	10	studies	study	NNS
cord-001835-0s7ok4uw	1934	11	that	that	WDT
cord-001835-0s7ok4uw	1934	12	provide	provide	VBP
cord-001835-0s7ok4uw	1934	13	a	a	DT
cord-001835-0s7ok4uw	1934	14	valuable	valuable	JJ
cord-001835-0s7ok4uw	1934	15	insight	insight	NN
cord-001835-0s7ok4uw	1934	16	into	into	IN
cord-001835-0s7ok4uw	1934	17	a	a	DT
cord-001835-0s7ok4uw	1934	18	chemical	chemical	JJ
cord-001835-0s7ok4uw	1934	19	degradation	degradation	NN
cord-001835-0s7ok4uw	1934	20	process	process	NN
cord-001835-0s7ok4uw	1934	21	and	and	CC
cord-001835-0s7ok4uw	1934	22	conformational	conformational	JJ
cord-001835-0s7ok4uw	1934	23	changes	change	NNS
cord-001835-0s7ok4uw	1934	24	of	of	IN
cord-001835-0s7ok4uw	1934	25	rHA	rHA	NNP
cord-001835-0s7ok4uw	1934	26	during	during	IN
cord-001835-0s7ok4uw	1934	27	storage	storage	NN
cord-001835-0s7ok4uw	1934	28	.	.	.
cord-001835-0s7ok4uw	1935	1	This	this	DT
cord-001835-0s7ok4uw	1935	2	work	work	NN
cord-001835-0s7ok4uw	1935	3	was	be	VBD
cord-001835-0s7ok4uw	1935	4	supported	support	VBN
cord-001835-0s7ok4uw	1935	5	by	by	IN
cord-001835-0s7ok4uw	1935	6	Innovative	Innovative	NNP
cord-001835-0s7ok4uw	1935	7	Economy	Economy	NNP
cord-001835-0s7ok4uw	1935	8	Operational	Operational	NNP
cord-001835-0s7ok4uw	1935	9	Program	Program	NNP
cord-001835-0s7ok4uw	1935	10	,	,	,
cord-001835-0s7ok4uw	1935	11	Grant	Grant	NNP
cord-001835-0s7ok4uw	1935	12	No	No	NNP
cord-001835-0s7ok4uw	1935	13	.	.	.
cord-001835-0s7ok4uw	1936	1	WND-	WND-	NNP
cord-001835-0s7ok4uw	1937	1	POIG.01.01.02	poig.01.01.02	JJ
cord-001835-0s7ok4uw	1937	2	-	-	HYPH
cord-001835-0s7ok4uw	1937	3	00	00	NFP
cord-001835-0s7ok4uw	1937	4	-	-	HYPH
cord-001835-0s7ok4uw	1937	5	007/08	007/08	CD
cord-001835-0s7ok4uw	1937	6	-	-	HYPH
cord-001835-0s7ok4uw	1937	7	00	00	NFP
cord-001835-0s7ok4uw	1937	8	as	as	IN
cord-001835-0s7ok4uw	1937	9	a	a	DT
cord-001835-0s7ok4uw	1937	10	part	part	NN
cord-001835-0s7ok4uw	1937	11	of	of	IN
cord-001835-0s7ok4uw	1937	12	project	project	NN
cord-001835-0s7ok4uw	1937	13	"	"	''
cord-001835-0s7ok4uw	1937	14	Centre	Centre	NNP
cord-001835-0s7ok4uw	1937	15	of	of	IN
cord-001835-0s7ok4uw	1937	16	medicinal	medicinal	JJ
cord-001835-0s7ok4uw	1937	17	product	product	NN
cord-001835-0s7ok4uw	1937	18	biotechnology	biotechnology	NN
cord-001835-0s7ok4uw	1937	19	.	.	.
cord-001835-0s7ok4uw	1938	1	Package	package	NN
cord-001835-0s7ok4uw	1938	2	of	of	IN
cord-001835-0s7ok4uw	1938	3	innovative	innovative	JJ
cord-001835-0s7ok4uw	1938	4	biopharmaceuticals	biopharmaceutical	NNS
cord-001835-0s7ok4uw	1938	5	for	for	IN
cord-001835-0s7ok4uw	1938	6	human	human	JJ
cord-001835-0s7ok4uw	1938	7	and	and	CC
cord-001835-0s7ok4uw	1938	8	animal	animal	NN
cord-001835-0s7ok4uw	1938	9	therapy	therapy	NN
cord-001835-0s7ok4uw	1938	10	and	and	CC
cord-001835-0s7ok4uw	1938	11	prophylactics	prophylactic	NNS
cord-001835-0s7ok4uw	1938	12	.	.	.
cord-001835-0s7ok4uw	1939	1	"	"	``
cord-001835-0s7ok4uw	1939	2	Muscle	muscle	NN
cord-001835-0s7ok4uw	1939	3	cell	cell	NN
cord-001835-0s7ok4uw	1939	4	atrophy	atrophy	NN
cord-001835-0s7ok4uw	1939	5	via	via	IN
cord-001835-0s7ok4uw	1939	6	HSP	HSP	NNP
cord-001835-0s7ok4uw	1939	7	gene	gene	NN
cord-001835-0s7ok4uw	1939	8	silencing	silencing	NN
cord-001835-0s7ok4uw	1939	9	was	be	VBD
cord-001835-0s7ok4uw	1939	10	counteracted	counteract	VBN
cord-001835-0s7ok4uw	1939	11	by	by	IN
cord-001835-0s7ok4uw	1939	12	celastrol	celastrol	NNP
cord-001835-0s7ok4uw	1939	13	-	-	HYPH
cord-001835-0s7ok4uw	1939	14	mediated	mediate	VBN
cord-001835-0s7ok4uw	1939	15	HSP	HSP	NNP
cord-001835-0s7ok4uw	1939	16	overexpression	overexpression	NN
cord-001835-0s7ok4uw	1939	17	Molecular	molecular	JJ
cord-001835-0s7ok4uw	1939	18	chaperone	chaperone	NN
cord-001835-0s7ok4uw	1939	19	heat	heat	NN
cord-001835-0s7ok4uw	1939	20	shock	shock	NN
cord-001835-0s7ok4uw	1939	21	proteins	protein	NNS
cord-001835-0s7ok4uw	1939	22	(	(	-LRB-
cord-001835-0s7ok4uw	1939	23	HSP	HSP	NNP
cord-001835-0s7ok4uw	1939	24	)	)	-RRB-
cord-001835-0s7ok4uw	1939	25	are	be	VBP
cord-001835-0s7ok4uw	1939	26	known	know	VBN
cord-001835-0s7ok4uw	1939	27	to	to	TO
cord-001835-0s7ok4uw	1939	28	assist	assist	VB
cord-001835-0s7ok4uw	1939	29	protein	protein	NN
cord-001835-0s7ok4uw	1939	30	quality	quality	NN
cord-001835-0s7ok4uw	1939	31	control	control	NN
cord-001835-0s7ok4uw	1939	32	under	under	IN
cord-001835-0s7ok4uw	1939	33	various	various	JJ
cord-001835-0s7ok4uw	1939	34	stresses	stress	NNS
cord-001835-0s7ok4uw	1939	35	.	.	.
cord-001835-0s7ok4uw	1940	1	Although	although	IN
cord-001835-0s7ok4uw	1940	2	overexpression	overexpression	NN
cord-001835-0s7ok4uw	1940	3	of	of	IN
cord-001835-0s7ok4uw	1940	4	HSP70	HSP70	NNP
cord-001835-0s7ok4uw	1940	5	was	be	VBD
cord-001835-0s7ok4uw	1940	6	found	find	VBN
cord-001835-0s7ok4uw	1940	7	to	to	TO
cord-001835-0s7ok4uw	1940	8	promote	promote	VB
cord-001835-0s7ok4uw	1940	9	muscle	muscle	NN
cord-001835-0s7ok4uw	1940	10	mass	mass	NN
cord-001835-0s7ok4uw	1940	11	retention	retention	NN
cord-001835-0s7ok4uw	1940	12	in	in	IN
cord-001835-0s7ok4uw	1940	13	an	an	DT
cord-001835-0s7ok4uw	1940	14	unloading	unloading	NN
cord-001835-0s7ok4uw	1940	15	state	state	NN
cord-001835-0s7ok4uw	1940	16	,	,	,
cord-001835-0s7ok4uw	1940	17	it	-PRON-	PRP
cord-001835-0s7ok4uw	1940	18	is	be	VBZ
cord-001835-0s7ok4uw	1940	19	unclear	unclear	JJ
cord-001835-0s7ok4uw	1940	20	whether	whether	IN
cord-001835-0s7ok4uw	1940	21	muscle	muscle	NN
cord-001835-0s7ok4uw	1940	22	atrophy	atrophy	NN
cord-001835-0s7ok4uw	1940	23	is	be	VBZ
cord-001835-0s7ok4uw	1940	24	induced	induce	VBN
cord-001835-0s7ok4uw	1940	25	by	by	IN
cord-001835-0s7ok4uw	1940	26	suppression	suppression	NN
cord-001835-0s7ok4uw	1940	27	of	of	IN
cord-001835-0s7ok4uw	1940	28	HSP	HSP	NNP
cord-001835-0s7ok4uw	1940	29	expression	expression	NN
cord-001835-0s7ok4uw	1940	30	and	and	CC
cord-001835-0s7ok4uw	1940	31	is	be	VBZ
cord-001835-0s7ok4uw	1940	32	counteracted	counteract	VBN
cord-001835-0s7ok4uw	1940	33	by	by	IN
cord-001835-0s7ok4uw	1940	34	active	active	JJ
cord-001835-0s7ok4uw	1940	35	HSP	HSP	NNP
cord-001835-0s7ok4uw	1940	36	overexpression	overexpression	NN
cord-001835-0s7ok4uw	1940	37	.	.	.
cord-001835-0s7ok4uw	1941	1	In	in	IN
cord-001835-0s7ok4uw	1941	2	this	this	DT
cord-001835-0s7ok4uw	1941	3	study	study	NN
cord-001835-0s7ok4uw	1941	4	,	,	,
cord-001835-0s7ok4uw	1941	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1941	6	pre	pre	VBD
cord-001835-0s7ok4uw	1941	7	-	-	VBD
cord-001835-0s7ok4uw	1941	8	treated	treat	VBN
cord-001835-0s7ok4uw	1941	9	Hsp70	Hsp70	NNP
cord-001835-0s7ok4uw	1941	10	siRNA	siRNA	NNP
cord-001835-0s7ok4uw	1941	11	to	to	TO
cord-001835-0s7ok4uw	1941	12	rat	rat	VB
cord-001835-0s7ok4uw	1941	13	L6	L6	NNP
cord-001835-0s7ok4uw	1941	14	cells	cell	NNS
cord-001835-0s7ok4uw	1941	15	for	for	IN
cord-001835-0s7ok4uw	1941	16	the	the	DT
cord-001835-0s7ok4uw	1941	17	HSP	HSP	NNP
cord-001835-0s7ok4uw	1941	18	gene	gene	NN
cord-001835-0s7ok4uw	1941	19	-	-	HYPH
cord-001835-0s7ok4uw	1941	20	silencing	silencing	NN
cord-001835-0s7ok4uw	1941	21	,	,	,
cord-001835-0s7ok4uw	1941	22	and	and	CC
cord-001835-0s7ok4uw	1941	23	determined	determine	VBD
cord-001835-0s7ok4uw	1941	24	myotube	myotube	NN
cord-001835-0s7ok4uw	1941	25	diameter	diameter	NN
cord-001835-0s7ok4uw	1941	26	,	,	,
cord-001835-0s7ok4uw	1941	27	HSP72	HSP72	NNP
cord-001835-0s7ok4uw	1941	28	expression	expression	NN
cord-001835-0s7ok4uw	1941	29	and	and	CC
cord-001835-0s7ok4uw	1941	30	anabolic	anabolic	JJ
cord-001835-0s7ok4uw	1941	31	and	and	CC
cord-001835-0s7ok4uw	1941	32	catabolic	catabolic	JJ
cord-001835-0s7ok4uw	1941	33	signaling	signal	VBG
cord-001835-0s7ok4uw	1941	34	activities	activity	NNS
cord-001835-0s7ok4uw	1941	35	in	in	IN
cord-001835-0s7ok4uw	1941	36	the	the	DT
cord-001835-0s7ok4uw	1941	37	absence	absence	NN
cord-001835-0s7ok4uw	1941	38	or	or	CC
cord-001835-0s7ok4uw	1941	39	presence	presence	NN
cord-001835-0s7ok4uw	1941	40	of	of	IN
cord-001835-0s7ok4uw	1941	41	triterpene	triterpene	NNP
cord-001835-0s7ok4uw	1941	42	celastrol	celastrol	NNP
cord-001835-0s7ok4uw	1941	43	(	(	-LRB-
cord-001835-0s7ok4uw	1941	44	CEL	CEL	NNP
cord-001835-0s7ok4uw	1941	45	)	)	-RRB-
cord-001835-0s7ok4uw	1941	46	,	,	,
cord-001835-0s7ok4uw	1941	47	the	the	DT
cord-001835-0s7ok4uw	1941	48	HSP70	HSP70	NNP
cord-001835-0s7ok4uw	1941	49	inducer	inducer	NN
cord-001835-0s7ok4uw	1941	50	.	.	.
cord-001835-0s7ok4uw	1942	1	Relative	relative	JJ
cord-001835-0s7ok4uw	1942	2	to	to	IN
cord-001835-0s7ok4uw	1942	3	a	a	DT
cord-001835-0s7ok4uw	1942	4	negative	negative	JJ
cord-001835-0s7ok4uw	1942	5	control	control	NN
cord-001835-0s7ok4uw	1942	6	(	(	-LRB-
cord-001835-0s7ok4uw	1942	7	NC	NC	NNP
cord-001835-0s7ok4uw	1942	8	)	)	-RRB-
cord-001835-0s7ok4uw	1942	9	,	,	,
cord-001835-0s7ok4uw	1942	10	muscle	muscle	NN
cord-001835-0s7ok4uw	1942	11	cell	cell	NN
cord-001835-0s7ok4uw	1942	12	diameter	diameter	NN
cord-001835-0s7ok4uw	1942	13	was	be	VBD
cord-001835-0s7ok4uw	1942	14	reduced	reduce	VBN
cord-001835-0s7ok4uw	1942	15	by	by	IN
cord-001835-0s7ok4uw	1942	16	11	11	CD
cord-001835-0s7ok4uw	1942	17	%	%	NN
cord-001835-0s7ok4uw	1942	18	in	in	IN
cord-001835-0s7ok4uw	1942	19	the	the	DT
cord-001835-0s7ok4uw	1942	20	siRNA	siRNA	NNP
cord-001835-0s7ok4uw	1942	21	-	-	HYPH
cord-001835-0s7ok4uw	1942	22	treated	treat	VBN
cord-001835-0s7ok4uw	1942	23	group	group	NN
cord-001835-0s7ok4uw	1942	24	,	,	,
cord-001835-0s7ok4uw	1942	25	increased	increase	VBD
cord-001835-0s7ok4uw	1942	26	1.2-fold	1.2-fold	CD
cord-001835-0s7ok4uw	1942	27	in	in	IN
cord-001835-0s7ok4uw	1942	28	the	the	DT
cord-001835-0s7ok4uw	1942	29	CEL	cel	NN
cord-001835-0s7ok4uw	1942	30	-	-	HYPH
cord-001835-0s7ok4uw	1942	31	treated	treat	VBN
cord-001835-0s7ok4uw	1942	32	group	group	NN
cord-001835-0s7ok4uw	1942	33	and	and	CC
cord-001835-0s7ok4uw	1942	34	remained	remain	VBD
cord-001835-0s7ok4uw	1942	35	at	at	IN
cord-001835-0s7ok4uw	1942	36	the	the	DT
cord-001835-0s7ok4uw	1942	37	size	size	NN
cord-001835-0s7ok4uw	1942	38	of	of	IN
cord-001835-0s7ok4uw	1942	39	NC	NC	NNP
cord-001835-0s7ok4uw	1942	40	in	in	IN
cord-001835-0s7ok4uw	1942	41	the	the	DT
cord-001835-0s7ok4uw	1942	42	siRNA1CEL	siRNA1CEL	NNP
cord-001835-0s7ok4uw	1942	43	group	group	NN
cord-001835-0s7ok4uw	1942	44	.	.	.
cord-001835-0s7ok4uw	1943	1	HSP72	hsp72	IN
cord-001835-0s7ok4uw	1943	2	expression	expression	NN
cord-001835-0s7ok4uw	1943	3	was	be	VBD
cord-001835-0s7ok4uw	1943	4	decreased	decrease	VBN
cord-001835-0s7ok4uw	1943	5	65	65	CD
cord-001835-0s7ok4uw	1943	6	%	%	NN
cord-001835-0s7ok4uw	1943	7	by	by	IN
cord-001835-0s7ok4uw	1943	8	siRNA	siRNA	NNP
cord-001835-0s7ok4uw	1943	9	whereas	whereas	IN
cord-001835-0s7ok4uw	1943	10	the	the	DT
cord-001835-0s7ok4uw	1943	11	level	level	NN
cord-001835-0s7ok4uw	1943	12	was	be	VBD
cord-001835-0s7ok4uw	1943	13	increased	increase	VBN
cord-001835-0s7ok4uw	1943	14	6-to	6-to	CD
cord-001835-0s7ok4uw	1943	15	8-fold	8-fold	CD
cord-001835-0s7ok4uw	1943	16	in	in	IN
cord-001835-0s7ok4uw	1943	17	the	the	DT
cord-001835-0s7ok4uw	1943	18	CEL	cel	NN
cord-001835-0s7ok4uw	1943	19	and	and	CC
cord-001835-0s7ok4uw	1943	20	siRNA1CEL	siRNA1CEL	NNP
cord-001835-0s7ok4uw	1943	21	groups	group	NNS
cord-001835-0s7ok4uw	1943	22	.	.	.
cord-001835-0s7ok4uw	1944	1	Expression	expression	NN
cord-001835-0s7ok4uw	1944	2	of	of	IN
cord-001835-0s7ok4uw	1944	3	FoxO3	FoxO3	NNP
cord-001835-0s7ok4uw	1944	4	and	and	CC
cord-001835-0s7ok4uw	1944	5	atrogin-1	atrogin-1	NNP
cord-001835-0s7ok4uw	1944	6	was	be	VBD
cord-001835-0s7ok4uw	1944	7	increased	increase	VBN
cord-001835-0s7ok4uw	1944	8	1.8-to	1.8-to	CD
cord-001835-0s7ok4uw	1944	9	4.8-fold	4.8-fold	CD
cord-001835-0s7ok4uw	1944	10	by	by	IN
cord-001835-0s7ok4uw	1944	11	siRNA	siRNA	NNP
cord-001835-0s7ok4uw	1944	12	,	,	,
cord-001835-0s7ok4uw	1944	13	which	which	WDT
cord-001835-0s7ok4uw	1944	14	was	be	VBD
cord-001835-0s7ok4uw	1944	15	abolished	abolish	VBN
cord-001835-0s7ok4uw	1944	16	by	by	IN
cord-001835-0s7ok4uw	1944	17	CEL	CEL	NNP
cord-001835-0s7ok4uw	1944	18	treatment	treatment	NN
cord-001835-0s7ok4uw	1944	19	.	.	.
cord-001835-0s7ok4uw	1945	1	Finally	finally	RB
cord-001835-0s7ok4uw	1945	2	,	,	,
cord-001835-0s7ok4uw	1945	3	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	1945	4	of	of	IN
cord-001835-0s7ok4uw	1945	5	Akt1	Akt1	NNP
cord-001835-0s7ok4uw	1945	6	,	,	,
cord-001835-0s7ok4uw	1945	7	S6	S6	NNP
cord-001835-0s7ok4uw	1945	8	K	K	NNP
cord-001835-0s7ok4uw	1945	9	and	and	CC
cord-001835-0s7ok4uw	1945	10	ERK1/2	ERK1/2	NNP
cord-001835-0s7ok4uw	1945	11	was	be	VBD
cord-001835-0s7ok4uw	1945	12	not	not	RB
cord-001835-0s7ok4uw	1945	13	affected	affect	VBN
cord-001835-0s7ok4uw	1945	14	by	by	IN
cord-001835-0s7ok4uw	1945	15	siRNA	siRNA	NNP
cord-001835-0s7ok4uw	1945	16	,	,	,
cord-001835-0s7ok4uw	1945	17	but	but	CC
cord-001835-0s7ok4uw	1945	18	was	be	VBD
cord-001835-0s7ok4uw	1945	19	elevated	elevate	VBN
cord-001835-0s7ok4uw	1945	20	2-to	2-to	CD
cord-001835-0s7ok4uw	1945	21	6-fold	6-fold	CD
cord-001835-0s7ok4uw	1945	22	in	in	IN
cord-001835-0s7ok4uw	1945	23	the	the	DT
cord-001835-0s7ok4uw	1945	24	CEL	cel	NN
cord-001835-0s7ok4uw	1945	25	and	and	CC
cord-001835-0s7ok4uw	1945	26	siRNA1CEL	siRNA1CEL	NNP
cord-001835-0s7ok4uw	1945	27	groups	group	NNS
cord-001835-0s7ok4uw	1945	28	.	.	.
cord-001835-0s7ok4uw	1946	1	These	these	DT
cord-001835-0s7ok4uw	1946	2	results	result	NNS
cord-001835-0s7ok4uw	1946	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	1946	4	that	that	IN
cord-001835-0s7ok4uw	1946	5	HSP	HSP	NNP
cord-001835-0s7ok4uw	1946	6	downregulation	downregulation	NN
cord-001835-0s7ok4uw	1946	7	by	by	IN
cord-001835-0s7ok4uw	1946	8	Hsp	Hsp	NNP
cord-001835-0s7ok4uw	1946	9	gene	gene	NN
cord-001835-0s7ok4uw	1946	10	-	-	HYPH
cord-001835-0s7ok4uw	1946	11	silencing	silencing	NN
cord-001835-0s7ok4uw	1946	12	led	lead	VBD
cord-001835-0s7ok4uw	1946	13	to	to	IN
cord-001835-0s7ok4uw	1946	14	muscle	muscle	NN
cord-001835-0s7ok4uw	1946	15	cell	cell	NN
cord-001835-0s7ok4uw	1946	16	atrophy	atrophy	NN
cord-001835-0s7ok4uw	1946	17	principally	principally	RB
cord-001835-0s7ok4uw	1946	18	via	via	IN
cord-001835-0s7ok4uw	1946	19	elevation	elevation	NN
cord-001835-0s7ok4uw	1946	20	of	of	IN
cord-001835-0s7ok4uw	1946	21	catabolic	catabolic	JJ
cord-001835-0s7ok4uw	1946	22	activities	activity	NNS
cord-001835-0s7ok4uw	1946	23	.	.	.
cord-001835-0s7ok4uw	1947	1	Such	such	JJ
cord-001835-0s7ok4uw	1947	2	anti	anti	JJ
cord-001835-0s7ok4uw	1947	3	-	-	JJ
cord-001835-0s7ok4uw	1947	4	atrophic	atrophic	JJ
cord-001835-0s7ok4uw	1947	5	effect	effect	NN
cord-001835-0s7ok4uw	1947	6	was	be	VBD
cord-001835-0s7ok4uw	1947	7	counteracted	counteract	VBN
cord-001835-0s7ok4uw	1947	8	by	by	IN
cord-001835-0s7ok4uw	1947	9	CEL	cel	NN
cord-001835-0s7ok4uw	1947	10	-	-	HYPH
cord-001835-0s7ok4uw	1947	11	mediated	mediate	VBN
cord-001835-0s7ok4uw	1947	12	HSP	HSP	NNP
cord-001835-0s7ok4uw	1947	13	overexpression	overexpression	NN
cord-001835-0s7ok4uw	1947	14	.	.	.
cord-001835-0s7ok4uw	1947	15	 	 	_SP
cord-001835-0s7ok4uw	1948	1	The	the	DT
cord-001835-0s7ok4uw	1948	2	Centers	Centers	NNPS
cord-001835-0s7ok4uw	1948	3	for	for	IN
cord-001835-0s7ok4uw	1948	4	Disease	Disease	NNP
cord-001835-0s7ok4uw	1948	5	Control	Control	NNP
cord-001835-0s7ok4uw	1948	6	and	and	CC
cord-001835-0s7ok4uw	1948	7	Prevention	Prevention	NNP
cord-001835-0s7ok4uw	1948	8	report	report	VBP
cord-001835-0s7ok4uw	1948	9	that	that	IN
cord-001835-0s7ok4uw	1948	10	at	at	RB
cord-001835-0s7ok4uw	1948	11	least	least	JJS
cord-001835-0s7ok4uw	1948	12	2	2	CD
cord-001835-0s7ok4uw	1948	13	million	million	CD
cord-001835-0s7ok4uw	1948	14	people	people	NNS
cord-001835-0s7ok4uw	1948	15	in	in	IN
cord-001835-0s7ok4uw	1948	16	the	the	DT
cord-001835-0s7ok4uw	1948	17	United	United	NNP
cord-001835-0s7ok4uw	1948	18	States	States	NNP
cord-001835-0s7ok4uw	1948	19	will	will	MD
cord-001835-0s7ok4uw	1948	20	become	become	VB
cord-001835-0s7ok4uw	1948	21	ill	ill	RB
cord-001835-0s7ok4uw	1948	22	due	due	IN
cord-001835-0s7ok4uw	1948	23	to	to	IN
cord-001835-0s7ok4uw	1948	24	antibiotic	antibiotic	JJ
cord-001835-0s7ok4uw	1948	25	resistant	resistant	JJ
cord-001835-0s7ok4uw	1948	26	pathogens	pathogen	NNS
cord-001835-0s7ok4uw	1948	27	leading	lead	VBG
cord-001835-0s7ok4uw	1948	28	to	to	IN
cord-001835-0s7ok4uw	1948	29	23,000	23,000	CD
cord-001835-0s7ok4uw	1948	30	deaths	death	NNS
cord-001835-0s7ok4uw	1948	31	each	each	DT
cord-001835-0s7ok4uw	1948	32	year	year	NN
cord-001835-0s7ok4uw	1948	33	.	.	.
cord-001835-0s7ok4uw	1949	1	In	in	IN
cord-001835-0s7ok4uw	1949	2	order	order	NN
cord-001835-0s7ok4uw	1949	3	to	to	TO
cord-001835-0s7ok4uw	1949	4	circumvent	circumvent	VB
cord-001835-0s7ok4uw	1949	5	these	these	DT
cord-001835-0s7ok4uw	1949	6	resistance	resistance	NN
cord-001835-0s7ok4uw	1949	7	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	1949	8	,	,	,
cord-001835-0s7ok4uw	1949	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	1949	10	is	be	VBZ
cord-001835-0s7ok4uw	1949	11	essential	essential	JJ
cord-001835-0s7ok4uw	1949	12	to	to	TO
cord-001835-0s7ok4uw	1949	13	quantitatively	quantitatively	RB
cord-001835-0s7ok4uw	1949	14	understand	understand	VB
cord-001835-0s7ok4uw	1949	15	how	how	WRB
cord-001835-0s7ok4uw	1949	16	the	the	DT
cord-001835-0s7ok4uw	1949	17	function	function	NN
cord-001835-0s7ok4uw	1949	18	of	of	IN
cord-001835-0s7ok4uw	1949	19	the	the	DT
cord-001835-0s7ok4uw	1949	20	protein(s	protein(s	NNP
cord-001835-0s7ok4uw	1949	21	)	)	-RRB-
cord-001835-0s7ok4uw	1949	22	involved	involve	VBN
cord-001835-0s7ok4uw	1949	23	relates	relate	VBZ
cord-001835-0s7ok4uw	1949	24	directly	directly	RB
cord-001835-0s7ok4uw	1949	25	to	to	IN
cord-001835-0s7ok4uw	1949	26	resistance	resistance	NN
cord-001835-0s7ok4uw	1949	27	.	.	.
cord-001835-0s7ok4uw	1950	1	Integral	integral	JJ
cord-001835-0s7ok4uw	1950	2	membrane	membrane	NN
cord-001835-0s7ok4uw	1950	3	efflux	efflux	NN
cord-001835-0s7ok4uw	1950	4	pumps	pump	NNS
cord-001835-0s7ok4uw	1950	5	are	be	VBP
cord-001835-0s7ok4uw	1950	6	known	know	VBN
cord-001835-0s7ok4uw	1950	7	determinants	determinant	NNS
cord-001835-0s7ok4uw	1950	8	of	of	IN
cord-001835-0s7ok4uw	1950	9	single	single	JJ
cord-001835-0s7ok4uw	1950	10	-	-	HYPH
cord-001835-0s7ok4uw	1950	11	drug	drug	NN
cord-001835-0s7ok4uw	1950	12	and	and	CC
cord-001835-0s7ok4uw	1950	13	multi	multi	JJ
cord-001835-0s7ok4uw	1950	14	-	-	JJ
cord-001835-0s7ok4uw	1950	15	drug	drug	JJ
cord-001835-0s7ok4uw	1950	16	resistance	resistance	NN
cord-001835-0s7ok4uw	1950	17	in	in	IN
cord-001835-0s7ok4uw	1950	18	a	a	DT
cord-001835-0s7ok4uw	1950	19	wide	wide	JJ
cord-001835-0s7ok4uw	1950	20	variety	variety	NN
cord-001835-0s7ok4uw	1950	21	of	of	IN
cord-001835-0s7ok4uw	1950	22	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	1950	23	organisms	organism	NNS
cord-001835-0s7ok4uw	1950	24	.	.	.
cord-001835-0s7ok4uw	1951	1	These	these	DT
cord-001835-0s7ok4uw	1951	2	transporters	transporter	NNS
cord-001835-0s7ok4uw	1951	3	are	be	VBP
cord-001835-0s7ok4uw	1951	4	proteins	protein	NNS
cord-001835-0s7ok4uw	1951	5	whose	whose	WP$
cord-001835-0s7ok4uw	1951	6	characterization	characterization	NN
cord-001835-0s7ok4uw	1951	7	typically	typically	RB
cord-001835-0s7ok4uw	1951	8	requires	require	VBZ
cord-001835-0s7ok4uw	1951	9	reconstitution	reconstitution	NN
cord-001835-0s7ok4uw	1951	10	in	in	IN
cord-001835-0s7ok4uw	1951	11	an	an	DT
cord-001835-0s7ok4uw	1951	12	artificial	artificial	JJ
cord-001835-0s7ok4uw	1951	13	membrane	membrane	NN
cord-001835-0s7ok4uw	1951	14	.	.	.
cord-001835-0s7ok4uw	1952	1	Subsequently	subsequently	RB
cord-001835-0s7ok4uw	1952	2	,	,	,
cord-001835-0s7ok4uw	1952	3	these	these	DT
cord-001835-0s7ok4uw	1952	4	important	important	JJ
cord-001835-0s7ok4uw	1952	5	proteins	protein	NNS
cord-001835-0s7ok4uw	1952	6	are	be	VBP
cord-001835-0s7ok4uw	1952	7	difficult	difficult	JJ
cord-001835-0s7ok4uw	1952	8	to	to	TO
cord-001835-0s7ok4uw	1952	9	characterize	characterize	VB
cord-001835-0s7ok4uw	1952	10	by	by	IN
cord-001835-0s7ok4uw	1952	11	traditional	traditional	JJ
cord-001835-0s7ok4uw	1952	12	in	in	IN
cord-001835-0s7ok4uw	1952	13	vitro	vitro	FW
cord-001835-0s7ok4uw	1952	14	studies	study	NNS
cord-001835-0s7ok4uw	1952	15	.	.	.
cord-001835-0s7ok4uw	1953	1	My	-PRON-	PRP$
cord-001835-0s7ok4uw	1953	2	project	project	NN
cord-001835-0s7ok4uw	1953	3	aims	aim	VBZ
cord-001835-0s7ok4uw	1953	4	to	to	TO
cord-001835-0s7ok4uw	1953	5	determine	determine	VB
cord-001835-0s7ok4uw	1953	6	the	the	DT
cord-001835-0s7ok4uw	1953	7	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	1953	8	parameters	parameter	NNS
cord-001835-0s7ok4uw	1953	9	of	of	IN
cord-001835-0s7ok4uw	1953	10	the	the	DT
cord-001835-0s7ok4uw	1953	11	efflux	efflux	NN
cord-001835-0s7ok4uw	1953	12	pump	pump	NN
cord-001835-0s7ok4uw	1953	13	TetB	TetB	NNP
cord-001835-0s7ok4uw	1953	14	utilizing	utilize	VBG
cord-001835-0s7ok4uw	1953	15	molecular	molecular	JJ
cord-001835-0s7ok4uw	1953	16	biology	biology	NN
cord-001835-0s7ok4uw	1953	17	and	and	CC
cord-001835-0s7ok4uw	1953	18	mathematical	mathematical	JJ
cord-001835-0s7ok4uw	1953	19	modeling	modeling	NN
cord-001835-0s7ok4uw	1953	20	.	.	.
cord-001835-0s7ok4uw	1954	1	TetB	TetB	NNP
cord-001835-0s7ok4uw	1954	2	is	be	VBZ
cord-001835-0s7ok4uw	1954	3	composed	compose	VBN
cord-001835-0s7ok4uw	1954	4	of	of	IN
cord-001835-0s7ok4uw	1954	5	12	12	CD
cord-001835-0s7ok4uw	1954	6	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	1954	7	(	(	-LRB-
cord-001835-0s7ok4uw	1954	8	TM	TM	NNP
cord-001835-0s7ok4uw	1954	9	)	)	-RRB-
cord-001835-0s7ok4uw	1954	10	alpha	alpha	NN
cord-001835-0s7ok4uw	1954	11	-	-	HYPH
cord-001835-0s7ok4uw	1954	12	helices	helix	NNS
cord-001835-0s7ok4uw	1954	13	and	and	CC
cord-001835-0s7ok4uw	1954	14	is	be	VBZ
cord-001835-0s7ok4uw	1954	15	found	find	VBN
cord-001835-0s7ok4uw	1954	16	within	within	IN
cord-001835-0s7ok4uw	1954	17	the	the	DT
cord-001835-0s7ok4uw	1954	18	inner	inner	JJ
cord-001835-0s7ok4uw	1954	19	membrane	membrane	NN
cord-001835-0s7ok4uw	1954	20	of	of	IN
cord-001835-0s7ok4uw	1954	21	Gram	gram	NN
cord-001835-0s7ok4uw	1954	22	-	-	HYPH
cord-001835-0s7ok4uw	1954	23	negative	negative	JJ
cord-001835-0s7ok4uw	1954	24	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	1954	25	.	.	.
cord-001835-0s7ok4uw	1955	1	This	this	DT
cord-001835-0s7ok4uw	1955	2	protein	protein	NN
cord-001835-0s7ok4uw	1955	3	allows	allow	VBZ
cord-001835-0s7ok4uw	1955	4	for	for	IN
cord-001835-0s7ok4uw	1955	5	the	the	DT
cord-001835-0s7ok4uw	1955	6	efflux	efflux	NN
cord-001835-0s7ok4uw	1955	7	of	of	IN
cord-001835-0s7ok4uw	1955	8	tetracycline	tetracycline	NNP
cord-001835-0s7ok4uw	1955	9	(	(	-LRB-
cord-001835-0s7ok4uw	1955	10	TET	TET	NNP
cord-001835-0s7ok4uw	1955	11	)	)	-RRB-
cord-001835-0s7ok4uw	1955	12	,	,	,
cord-001835-0s7ok4uw	1955	13	doxycycline	doxycycline	FW
cord-001835-0s7ok4uw	1955	14	(	(	-LRB-
cord-001835-0s7ok4uw	1955	15	DOX	DOX	NNP
cord-001835-0s7ok4uw	1955	16	)	)	-RRB-
cord-001835-0s7ok4uw	1955	17	,	,	,
cord-001835-0s7ok4uw	1955	18	and	and	CC
cord-001835-0s7ok4uw	1955	19	minocycline	minocycline	NNP
cord-001835-0s7ok4uw	1955	20	(	(	-LRB-
cord-001835-0s7ok4uw	1955	21	MCN	MCN	NNP
cord-001835-0s7ok4uw	1955	22	)	)	-RRB-
cord-001835-0s7ok4uw	1955	23	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	1955	24	from	from	IN
cord-001835-0s7ok4uw	1955	25	the	the	DT
cord-001835-0s7ok4uw	1955	26	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	1955	27	into	into	IN
cord-001835-0s7ok4uw	1955	28	the	the	DT
cord-001835-0s7ok4uw	1955	29	periplasm	periplasm	NN
cord-001835-0s7ok4uw	1955	30	.	.	.
cord-001835-0s7ok4uw	1956	1	These	these	DT
cord-001835-0s7ok4uw	1956	2	tetracyclines	tetracycline	NNS
cord-001835-0s7ok4uw	1956	3	are	be	VBP
cord-001835-0s7ok4uw	1956	4	a	a	DT
cord-001835-0s7ok4uw	1956	5	bacteriostatic	bacteriostatic	JJ
cord-001835-0s7ok4uw	1956	6	class	class	NN
cord-001835-0s7ok4uw	1956	7	of	of	IN
cord-001835-0s7ok4uw	1956	8	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	1956	9	that	that	WDT
cord-001835-0s7ok4uw	1956	10	inhibit	inhibit	VBP
cord-001835-0s7ok4uw	1956	11	protein	protein	NN
cord-001835-0s7ok4uw	1956	12	synthesis	synthesis	NN
cord-001835-0s7ok4uw	1956	13	by	by	IN
cord-001835-0s7ok4uw	1956	14	binding	bind	VBG
cord-001835-0s7ok4uw	1956	15	to	to	IN
cord-001835-0s7ok4uw	1956	16	the	the	DT
cord-001835-0s7ok4uw	1956	17	30S	30s	CD
cord-001835-0s7ok4uw	1956	18	ribosomal	ribosomal	NN
cord-001835-0s7ok4uw	1956	19	,	,	,
cord-001835-0s7ok4uw	1956	20	therefore	therefore	RB
cord-001835-0s7ok4uw	1956	21	,	,	,
cord-001835-0s7ok4uw	1956	22	blocking	block	VBG
cord-001835-0s7ok4uw	1956	23	the	the	DT
cord-001835-0s7ok4uw	1956	24	binding	binding	NN
cord-001835-0s7ok4uw	1956	25	of	of	IN
cord-001835-0s7ok4uw	1956	26	aminoacyl	aminoacyl	NNP
cord-001835-0s7ok4uw	1956	27	-	-	HYPH
cord-001835-0s7ok4uw	1956	28	tRNA	trna	NN
cord-001835-0s7ok4uw	1956	29	.	.	.
cord-001835-0s7ok4uw	1957	1	For	for	IN
cord-001835-0s7ok4uw	1957	2	cells	cell	NNS
cord-001835-0s7ok4uw	1957	3	grown	grow	VBN
cord-001835-0s7ok4uw	1957	4	in	in	IN
cord-001835-0s7ok4uw	1957	5	tetracyclines	tetracycline	NNS
cord-001835-0s7ok4uw	1957	6	,	,	,
cord-001835-0s7ok4uw	1957	7	the	the	DT
cord-001835-0s7ok4uw	1957	8	efflux	efflux	NN
cord-001835-0s7ok4uw	1957	9	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1957	10	of	of	IN
cord-001835-0s7ok4uw	1957	11	TetB	TetB	NNP
cord-001835-0s7ok4uw	1957	12	decreases	decrease	VBZ
cord-001835-0s7ok4uw	1957	13	the	the	DT
cord-001835-0s7ok4uw	1957	14	cytosolic	cytosolic	JJ
cord-001835-0s7ok4uw	1957	15	antibiotic	antibiotic	JJ
cord-001835-0s7ok4uw	1957	16	concentration	concentration	NN
cord-001835-0s7ok4uw	1957	17	allowing	allow	VBG
cord-001835-0s7ok4uw	1957	18	for	for	IN
cord-001835-0s7ok4uw	1957	19	the	the	DT
cord-001835-0s7ok4uw	1957	20	rate	rate	NN
cord-001835-0s7ok4uw	1957	21	of	of	IN
cord-001835-0s7ok4uw	1957	22	protein	protein	NN
cord-001835-0s7ok4uw	1957	23	translation	translation	NN
cord-001835-0s7ok4uw	1957	24	to	to	TO
cord-001835-0s7ok4uw	1957	25	increase	increase	VB
cord-001835-0s7ok4uw	1957	26	.	.	.
cord-001835-0s7ok4uw	1958	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	1958	2	have	have	VBP
cord-001835-0s7ok4uw	1958	3	inserted	insert	VBN
cord-001835-0s7ok4uw	1958	4	a	a	DT
cord-001835-0s7ok4uw	1958	5	tet(B	tet(b	JJ
cord-001835-0s7ok4uw	1958	6	)	)	-RRB-
cord-001835-0s7ok4uw	1958	7	expression	expression	NN
cord-001835-0s7ok4uw	1958	8	system	system	NN
cord-001835-0s7ok4uw	1958	9	into	into	IN
cord-001835-0s7ok4uw	1958	10	the	the	DT
cord-001835-0s7ok4uw	1958	11	chromosome	chromosome	NN
cord-001835-0s7ok4uw	1958	12	of	of	IN
cord-001835-0s7ok4uw	1958	13	an	an	DT
cord-001835-0s7ok4uw	1958	14	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	1958	15	coli	coli	NNS
cord-001835-0s7ok4uw	1958	16	lab	lab	NN
cord-001835-0s7ok4uw	1958	17	strain	strain	NN
cord-001835-0s7ok4uw	1958	18	and	and	CC
cord-001835-0s7ok4uw	1958	19	have	have	VBP
cord-001835-0s7ok4uw	1958	20	determined	determine	VBN
cord-001835-0s7ok4uw	1958	21	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1958	22	growth	growth	NN
cord-001835-0s7ok4uw	1958	23	profile	profile	NN
cord-001835-0s7ok4uw	1958	24	under	under	IN
cord-001835-0s7ok4uw	1958	25	various	various	JJ
cord-001835-0s7ok4uw	1958	26	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1958	27	of	of	IN
cord-001835-0s7ok4uw	1958	28	TET	TET	NNP
cord-001835-0s7ok4uw	1958	29	,	,	,
cord-001835-0s7ok4uw	1958	30	MCN	MCN	NNP
cord-001835-0s7ok4uw	1958	31	,	,	,
cord-001835-0s7ok4uw	1958	32	and	and	CC
cord-001835-0s7ok4uw	1958	33	DOX	DOX	NNP
cord-001835-0s7ok4uw	1958	34	using	use	VBG
cord-001835-0s7ok4uw	1958	35	a	a	DT
cord-001835-0s7ok4uw	1958	36	high	high	JJ
cord-001835-0s7ok4uw	1958	37	-	-	HYPH
cord-001835-0s7ok4uw	1958	38	throughput	throughput	NN
cord-001835-0s7ok4uw	1958	39	96-well	96-well	CD
cord-001835-0s7ok4uw	1958	40	plate	plate	NN
cord-001835-0s7ok4uw	1958	41	format	format	NN
cord-001835-0s7ok4uw	1958	42	.	.	.
cord-001835-0s7ok4uw	1959	1	The	the	DT
cord-001835-0s7ok4uw	1959	2	growth	growth	NN
cord-001835-0s7ok4uw	1959	3	rate	rate	NN
cord-001835-0s7ok4uw	1959	4	profiles	profile	NNS
cord-001835-0s7ok4uw	1959	5	correlate	correlate	VBP
cord-001835-0s7ok4uw	1959	6	with	with	IN
cord-001835-0s7ok4uw	1959	7	TetB	TetB	NNP
cord-001835-0s7ok4uw	1959	8	pumping	pump	VBG
cord-001835-0s7ok4uw	1959	9	rates	rate	NNS
cord-001835-0s7ok4uw	1959	10	for	for	IN
cord-001835-0s7ok4uw	1959	11	each	each	DT
cord-001835-0s7ok4uw	1959	12	drug	drug	NN
cord-001835-0s7ok4uw	1959	13	.	.	.
cord-001835-0s7ok4uw	1960	1	TetB	TetB	NNP
cord-001835-0s7ok4uw	1960	2	more	more	RBR
cord-001835-0s7ok4uw	1960	3	readily	readily	RB
cord-001835-0s7ok4uw	1960	4	pumps	pump	VBZ
cord-001835-0s7ok4uw	1960	5	out	out	RP
cord-001835-0s7ok4uw	1960	6	TET	TET	NNP
cord-001835-0s7ok4uw	1960	7	compared	compare	VBN
cord-001835-0s7ok4uw	1960	8	with	with	IN
cord-001835-0s7ok4uw	1960	9	DOX	DOX	NNP
cord-001835-0s7ok4uw	1960	10	and	and	CC
cord-001835-0s7ok4uw	1960	11	MCN	MCN	NNP
cord-001835-0s7ok4uw	1960	12	and	and	CC
cord-001835-0s7ok4uw	1960	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	1960	14	observe	observe	VBP
cord-001835-0s7ok4uw	1960	15	that	that	IN
cord-001835-0s7ok4uw	1960	16	cells	cell	NNS
cord-001835-0s7ok4uw	1960	17	expressing	express	VBG
cord-001835-0s7ok4uw	1960	18	TetB	TetB	NNP
cord-001835-0s7ok4uw	1960	19	can	can	MD
cord-001835-0s7ok4uw	1960	20	grow	grow	VB
cord-001835-0s7ok4uw	1960	21	at	at	IN
cord-001835-0s7ok4uw	1960	22	higher	high	JJR
cord-001835-0s7ok4uw	1960	23	TET	TET	NNP
cord-001835-0s7ok4uw	1960	24	concentrations	concentration	NNS
cord-001835-0s7ok4uw	1960	25	compared	compare	VBN
cord-001835-0s7ok4uw	1960	26	with	with	IN
cord-001835-0s7ok4uw	1960	27	DOX	DOX	NNP
cord-001835-0s7ok4uw	1960	28	and	and	CC
cord-001835-0s7ok4uw	1960	29	MCN	MCN	NNP
cord-001835-0s7ok4uw	1960	30	.	.	.
cord-001835-0s7ok4uw	1961	1	The	the	DT
cord-001835-0s7ok4uw	1961	2	shapes	shape	NNS
cord-001835-0s7ok4uw	1961	3	of	of	IN
cord-001835-0s7ok4uw	1961	4	the	the	DT
cord-001835-0s7ok4uw	1961	5	growth	growth	NN
cord-001835-0s7ok4uw	1961	6	rate	rate	NN
cord-001835-0s7ok4uw	1961	7	profiles	profile	NNS
cord-001835-0s7ok4uw	1961	8	produced	produce	VBN
cord-001835-0s7ok4uw	1961	9	in	in	IN
cord-001835-0s7ok4uw	1961	10	the	the	DT
cord-001835-0s7ok4uw	1961	11	different	different	JJ
cord-001835-0s7ok4uw	1961	12	drugs	drug	NNS
cord-001835-0s7ok4uw	1961	13	give	give	VBP
cord-001835-0s7ok4uw	1961	14	insight	insight	NN
cord-001835-0s7ok4uw	1961	15	into	into	IN
cord-001835-0s7ok4uw	1961	16	the	the	DT
cord-001835-0s7ok4uw	1961	17	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	1961	18	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1961	19	of	of	IN
cord-001835-0s7ok4uw	1961	20	TetB.	tetb.	NN
cord-001835-0s7ok4uw	1962	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1962	2	have	have	VBP
cord-001835-0s7ok4uw	1962	3	built	build	VBN
cord-001835-0s7ok4uw	1962	4	a	a	DT
cord-001835-0s7ok4uw	1962	5	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	1962	6	mathematical	mathematical	JJ
cord-001835-0s7ok4uw	1962	7	model	model	NN
cord-001835-0s7ok4uw	1962	8	that	that	WDT
cord-001835-0s7ok4uw	1962	9	can	can	MD
cord-001835-0s7ok4uw	1962	10	simulate	simulate	VB
cord-001835-0s7ok4uw	1962	11	these	these	DT
cord-001835-0s7ok4uw	1962	12	growth	growth	NN
cord-001835-0s7ok4uw	1962	13	profiles	profile	NNS
cord-001835-0s7ok4uw	1962	14	and	and	CC
cord-001835-0s7ok4uw	1962	15	predict	predict	VB
cord-001835-0s7ok4uw	1962	16	efflux	efflux	NN
cord-001835-0s7ok4uw	1962	17	pump	pump	NN
cord-001835-0s7ok4uw	1962	18	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	1962	19	parameters	parameter	NNS
cord-001835-0s7ok4uw	1962	20	.	.	.
cord-001835-0s7ok4uw	1963	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1963	2	are	be	VBP
cord-001835-0s7ok4uw	1963	3	currently	currently	RB
cord-001835-0s7ok4uw	1963	4	working	work	VBG
cord-001835-0s7ok4uw	1963	5	on	on	IN
cord-001835-0s7ok4uw	1963	6	understanding	understand	VBG
cord-001835-0s7ok4uw	1963	7	how	how	WRB
cord-001835-0s7ok4uw	1963	8	efflux	efflux	NN
cord-001835-0s7ok4uw	1963	9	expression	expression	NN
cord-001835-0s7ok4uw	1963	10	effects	effect	NNS
cord-001835-0s7ok4uw	1963	11	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	1963	12	growth	growth	NN
cord-001835-0s7ok4uw	1963	13	by	by	IN
cord-001835-0s7ok4uw	1963	14	testing	test	VBG
cord-001835-0s7ok4uw	1963	15	ribosome	ribosome	NN
cord-001835-0s7ok4uw	1963	16	binding	binding	NN
cord-001835-0s7ok4uw	1963	17	site	site	NN
cord-001835-0s7ok4uw	1963	18	(	(	-LRB-
cord-001835-0s7ok4uw	1963	19	RBS	RBS	NNP
cord-001835-0s7ok4uw	1963	20	)	)	-RRB-
cord-001835-0s7ok4uw	1963	21	sequences	sequence	NNS
cord-001835-0s7ok4uw	1963	22	of	of	IN
cord-001835-0s7ok4uw	1963	23	varying	vary	VBG
cord-001835-0s7ok4uw	1963	24	strengths	strength	NNS
cord-001835-0s7ok4uw	1963	25	in	in	IN
cord-001835-0s7ok4uw	1963	26	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1963	27	tet(B	tet(b	JJ
cord-001835-0s7ok4uw	1963	28	)	)	-RRB-
cord-001835-0s7ok4uw	1963	29	expression	expression	NN
cord-001835-0s7ok4uw	1963	30	system	system	NN
cord-001835-0s7ok4uw	1963	31	.	.	.
cord-001835-0s7ok4uw	1964	1	Future	future	JJ
cord-001835-0s7ok4uw	1964	2	work	work	NN
cord-001835-0s7ok4uw	1964	3	is	be	VBZ
cord-001835-0s7ok4uw	1964	4	geared	gear	VBN
cord-001835-0s7ok4uw	1964	5	toward	toward	IN
cord-001835-0s7ok4uw	1964	6	modeling	model	VBG
cord-001835-0s7ok4uw	1964	7	more	more	RBR
cord-001835-0s7ok4uw	1964	8	complex	complex	JJ
cord-001835-0s7ok4uw	1964	9	efflux	efflux	NN
cord-001835-0s7ok4uw	1964	10	pumps	pump	NNS
cord-001835-0s7ok4uw	1964	11	such	such	JJ
cord-001835-0s7ok4uw	1964	12	as	as	IN
cord-001835-0s7ok4uw	1964	13	the	the	DT
cord-001835-0s7ok4uw	1964	14	tripartite	tripartite	JJ
cord-001835-0s7ok4uw	1964	15	pumps	pump	NNS
cord-001835-0s7ok4uw	1964	16	which	which	WDT
cord-001835-0s7ok4uw	1964	17	traverse	traverse	VBP
cord-001835-0s7ok4uw	1964	18	both	both	DT
cord-001835-0s7ok4uw	1964	19	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	1964	20	membranes	membrane	NNS
cord-001835-0s7ok4uw	1964	21	and	and	CC
cord-001835-0s7ok4uw	1964	22	cause	cause	VB
cord-001835-0s7ok4uw	1964	23	multi	multi	JJ
cord-001835-0s7ok4uw	1964	24	-	-	JJ
cord-001835-0s7ok4uw	1964	25	drug	drug	JJ
cord-001835-0s7ok4uw	1964	26	resistance	resistance	NN
cord-001835-0s7ok4uw	1964	27	.	.	.
cord-001835-0s7ok4uw	1965	1	Collectively	collectively	RB
cord-001835-0s7ok4uw	1965	2	,	,	,
cord-001835-0s7ok4uw	1965	3	this	this	DT
cord-001835-0s7ok4uw	1965	4	project	project	NN
cord-001835-0s7ok4uw	1965	5	aims	aim	VBZ
cord-001835-0s7ok4uw	1965	6	to	to	TO
cord-001835-0s7ok4uw	1965	7	build	build	VB
cord-001835-0s7ok4uw	1965	8	an	an	DT
cord-001835-0s7ok4uw	1965	9	in	in	IN
cord-001835-0s7ok4uw	1965	10	vivo	vivo	NN
cord-001835-0s7ok4uw	1965	11	system	system	NN
cord-001835-0s7ok4uw	1965	12	which	which	WDT
cord-001835-0s7ok4uw	1965	13	will	will	MD
cord-001835-0s7ok4uw	1965	14	allow	allow	VB
cord-001835-0s7ok4uw	1965	15	for	for	IN
cord-001835-0s7ok4uw	1965	16	the	the	DT
cord-001835-0s7ok4uw	1965	17	characterization	characterization	NN
cord-001835-0s7ok4uw	1965	18	of	of	IN
cord-001835-0s7ok4uw	1965	19	a	a	DT
cord-001835-0s7ok4uw	1965	20	variety	variety	NN
cord-001835-0s7ok4uw	1965	21	of	of	IN
cord-001835-0s7ok4uw	1965	22	efflux	efflux	NN
cord-001835-0s7ok4uw	1965	23	pumps	pump	NNS
cord-001835-0s7ok4uw	1965	24	without	without	IN
cord-001835-0s7ok4uw	1965	25	the	the	DT
cord-001835-0s7ok4uw	1965	26	arduous	arduous	JJ
cord-001835-0s7ok4uw	1965	27	tasks	task	NNS
cord-001835-0s7ok4uw	1965	28	of	of	IN
cord-001835-0s7ok4uw	1965	29	protein	protein	NN
cord-001835-0s7ok4uw	1965	30	purification	purification	NN
cord-001835-0s7ok4uw	1965	31	and	and	CC
cord-001835-0s7ok4uw	1965	32	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	1965	33	reconstitution	reconstitution	NN
cord-001835-0s7ok4uw	1965	34	.	.	.
cord-001835-0s7ok4uw	1966	1	(	(	-LRB-
cord-001835-0s7ok4uw	1966	2	2007	2007	CD
cord-001835-0s7ok4uw	1966	3	)	)	-RRB-
cord-001835-0s7ok4uw	1966	4	identified	identify	VBD
cord-001835-0s7ok4uw	1966	5	a	a	DT
cord-001835-0s7ok4uw	1966	6	small	small	JJ
cord-001835-0s7ok4uw	1966	7	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	1966	8	region	region	NN
cord-001835-0s7ok4uw	1966	9	of	of	IN
cord-001835-0s7ok4uw	1966	10	both	both	DT
cord-001835-0s7ok4uw	1966	11	KCNE1	KCNE1	NNS
cord-001835-0s7ok4uw	1966	12	and	and	CC
cord-001835-0s7ok4uw	1966	13	KCNE3	kcne3	XX
cord-001835-0s7ok4uw	1966	14	that	that	WDT
cord-001835-0s7ok4uw	1966	15	are	be	VBP
cord-001835-0s7ok4uw	1966	16	essential	essential	JJ
cord-001835-0s7ok4uw	1966	17	for	for	IN
cord-001835-0s7ok4uw	1966	18	their	-PRON-	PRP$
cord-001835-0s7ok4uw	1966	19	unique	unique	JJ
cord-001835-0s7ok4uw	1966	20	modulation	modulation	NN
cord-001835-0s7ok4uw	1966	21	of	of	IN
cord-001835-0s7ok4uw	1966	22	the	the	DT
cord-001835-0s7ok4uw	1966	23	KCNQ1	KCNQ1	NNP
cord-001835-0s7ok4uw	1966	24	channel	channel	NNP
cord-001835-0s7ok4uw	1966	25	.	.	.
cord-001835-0s7ok4uw	1967	1	By	by	IN
cord-001835-0s7ok4uw	1967	2	swapping	swap	VBG
cord-001835-0s7ok4uw	1967	3	a	a	DT
cord-001835-0s7ok4uw	1967	4	triplet	triplet	NN
cord-001835-0s7ok4uw	1967	5	motif	motif	NN
cord-001835-0s7ok4uw	1967	6	in	in	IN
cord-001835-0s7ok4uw	1967	7	the	the	DT
cord-001835-0s7ok4uw	1967	8	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	1967	9	region	region	NN
cord-001835-0s7ok4uw	1967	10	of	of	IN
cord-001835-0s7ok4uw	1967	11	KCNE1	kcne1	NN
cord-001835-0s7ok4uw	1967	12	and	and	CC
cord-001835-0s7ok4uw	1967	13	KCNE3	KCNE3	NNPS
cord-001835-0s7ok4uw	1967	14	,	,	,
cord-001835-0s7ok4uw	1967	15	we	-PRON-	PRP
cord-001835-0s7ok4uw	1967	16	can	can	MD
cord-001835-0s7ok4uw	1967	17	flip	flip	VB
cord-001835-0s7ok4uw	1967	18	the	the	DT
cord-001835-0s7ok4uw	1967	19	primary	primary	JJ
cord-001835-0s7ok4uw	1967	20	function	function	NN
cord-001835-0s7ok4uw	1967	21	of	of	IN
cord-001835-0s7ok4uw	1967	22	these	these	DT
cord-001835-0s7ok4uw	1967	23	two	two	CD
cord-001835-0s7ok4uw	1967	24	proteins	protein	NNS
cord-001835-0s7ok4uw	1967	25	.	.	.
cord-001835-0s7ok4uw	1968	1	While	while	IN
cord-001835-0s7ok4uw	1968	2	the	the	DT
cord-001835-0s7ok4uw	1968	3	key	key	NN
cord-001835-0s7ok4uw	1968	4	for	for	IN
cord-001835-0s7ok4uw	1968	5	KCNE1	KCNE1	NNS
cord-001835-0s7ok4uw	1968	6	and	and	CC
cord-001835-0s7ok4uw	1968	7	KCNE3	KCNE3	NNP
cord-001835-0s7ok4uw	1968	8	's	's	POS
cord-001835-0s7ok4uw	1968	9	unique	unique	JJ
cord-001835-0s7ok4uw	1968	10	modulating	modulating	NN
cord-001835-0s7ok4uw	1968	11	is	be	VBZ
cord-001835-0s7ok4uw	1968	12	believed	believe	VBN
cord-001835-0s7ok4uw	1968	13	to	to	TO
cord-001835-0s7ok4uw	1968	14	lie	lie	VB
cord-001835-0s7ok4uw	1968	15	in	in	IN
cord-001835-0s7ok4uw	1968	16	this	this	DT
cord-001835-0s7ok4uw	1968	17	triplet	triplet	NN
cord-001835-0s7ok4uw	1968	18	motif	motif	NN
cord-001835-0s7ok4uw	1968	19	,	,	,
cord-001835-0s7ok4uw	1968	20	the	the	DT
cord-001835-0s7ok4uw	1968	21	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1968	22	and	and	CC
cord-001835-0s7ok4uw	1968	23	structural	structural	JJ
cord-001835-0s7ok4uw	1968	24	changes	change	NNS
cord-001835-0s7ok4uw	1968	25	involved	involve	VBN
cord-001835-0s7ok4uw	1968	26	in	in	IN
cord-001835-0s7ok4uw	1968	27	this	this	DT
cord-001835-0s7ok4uw	1968	28	modulation	modulation	NN
cord-001835-0s7ok4uw	1968	29	is	be	VBZ
cord-001835-0s7ok4uw	1968	30	not	not	RB
cord-001835-0s7ok4uw	1968	31	fully	fully	RB
cord-001835-0s7ok4uw	1968	32	understood	understand	VBN
cord-001835-0s7ok4uw	1968	33	.	.	.
cord-001835-0s7ok4uw	1969	1	By	by	IN
cord-001835-0s7ok4uw	1969	2	using	use	VBG
cord-001835-0s7ok4uw	1969	3	NMR	NMR	NNP
cord-001835-0s7ok4uw	1969	4	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1969	5	,	,	,
cord-001835-0s7ok4uw	1969	6	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	1969	7	studies	study	NNS
cord-001835-0s7ok4uw	1969	8	,	,	,
cord-001835-0s7ok4uw	1969	9	and	and	CC
cord-001835-0s7ok4uw	1969	10	computational	computational	JJ
cord-001835-0s7ok4uw	1969	11	docking	docking	NN
cord-001835-0s7ok4uw	1969	12	,	,	,
cord-001835-0s7ok4uw	1969	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	1969	14	aim	aim	VBP
cord-001835-0s7ok4uw	1969	15	to	to	TO
cord-001835-0s7ok4uw	1969	16	look	look	VB
cord-001835-0s7ok4uw	1969	17	at	at	IN
cord-001835-0s7ok4uw	1969	18	the	the	DT
cord-001835-0s7ok4uw	1969	19	structural	structural	JJ
cord-001835-0s7ok4uw	1969	20	and	and	CC
cord-001835-0s7ok4uw	1969	21	conformational	conformational	JJ
cord-001835-0s7ok4uw	1969	22	differences	difference	NNS
cord-001835-0s7ok4uw	1969	23	between	between	IN
cord-001835-0s7ok4uw	1969	24	KCNE1	kcne1	NN
cord-001835-0s7ok4uw	1969	25	and	and	CC
cord-001835-0s7ok4uw	1969	26	the	the	DT
cord-001835-0s7ok4uw	1969	27	triple	triple	JJ
cord-001835-0s7ok4uw	1969	28	mutant	mutant	JJ
cord-001835-0s7ok4uw	1969	29	KCNE1	KCNE1	NNS
cord-001835-0s7ok4uw	1969	30	substituted	substitute	VBN
cord-001835-0s7ok4uw	1969	31	with	with	IN
cord-001835-0s7ok4uw	1969	32	the	the	DT
cord-001835-0s7ok4uw	1969	33	three	three	CD
cord-001835-0s7ok4uw	1969	34	essential	essential	JJ
cord-001835-0s7ok4uw	1969	35	KCNE3	kcne3	JJ
cord-001835-0s7ok4uw	1969	36	residues	residue	NNS
cord-001835-0s7ok4uw	1969	37	.	.	.
cord-001835-0s7ok4uw	1970	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	1970	2	have	have	VBP
cord-001835-0s7ok4uw	1970	3	expressed	express	VBN
cord-001835-0s7ok4uw	1970	4	and	and	CC
cord-001835-0s7ok4uw	1970	5	purified	purify	VBN
cord-001835-0s7ok4uw	1970	6	15N	15n	CD
cord-001835-0s7ok4uw	1970	7	-	-	HYPH
cord-001835-0s7ok4uw	1970	8	labled	lable	VBN
cord-001835-0s7ok4uw	1970	9	KCNE1	kcne1	NN
cord-001835-0s7ok4uw	1970	10	triple	triple	JJ
cord-001835-0s7ok4uw	1970	11	-	-	HYPH
cord-001835-0s7ok4uw	1970	12	mutant	mutant	JJ
cord-001835-0s7ok4uw	1970	13	in	in	IN
cord-001835-0s7ok4uw	1970	14	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	1970	15	quantities	quantity	NNS
cord-001835-0s7ok4uw	1970	16	for	for	IN
cord-001835-0s7ok4uw	1970	17	NMR	NMR	NNP
cord-001835-0s7ok4uw	1970	18	studies	study	NNS
cord-001835-0s7ok4uw	1970	19	in	in	IN
cord-001835-0s7ok4uw	1970	20	LMPG	LMPG	NNP
cord-001835-0s7ok4uw	1970	21	detergent	detergent	NN
cord-001835-0s7ok4uw	1970	22	micelles	micelle	NNS
cord-001835-0s7ok4uw	1970	23	and	and	CC
cord-001835-0s7ok4uw	1970	24	other	other	JJ
cord-001835-0s7ok4uw	1970	25	membrane	membrane	NN
cord-001835-0s7ok4uw	1970	26	mimetics	mimetic	NNS
cord-001835-0s7ok4uw	1970	27	,	,	,
cord-001835-0s7ok4uw	1970	28	and	and	CC
cord-001835-0s7ok4uw	1970	29	we	-PRON-	PRP
cord-001835-0s7ok4uw	1970	30	have	have	VBP
cord-001835-0s7ok4uw	1970	31	collected	collect	VBN
cord-001835-0s7ok4uw	1970	32	2D	2d	JJ
cord-001835-0s7ok4uw	1970	33	NMR	NMR	NNP
cord-001835-0s7ok4uw	1970	34	spectra	spectrum	NNS
cord-001835-0s7ok4uw	1970	35	using	use	VBG
cord-001835-0s7ok4uw	1970	36	a	a	DT
cord-001835-0s7ok4uw	1970	37	TROSY	TROSY	NNP
cord-001835-0s7ok4uw	1970	38	-	-	HYPH
cord-001835-0s7ok4uw	1970	39	based	base	VBN
cord-001835-0s7ok4uw	1970	40	pulse	pulse	NN
cord-001835-0s7ok4uw	1970	41	sequence	sequence	NN
cord-001835-0s7ok4uw	1970	42	.	.	.
cord-001835-0s7ok4uw	1971	1	Partial	partial	JJ
cord-001835-0s7ok4uw	1971	2	backbone	backbone	NN
cord-001835-0s7ok4uw	1971	3	assignments	assignment	NNS
cord-001835-0s7ok4uw	1971	4	of	of	IN
cord-001835-0s7ok4uw	1971	5	KCNE1	kcne1	NN
cord-001835-0s7ok4uw	1971	6	triple	triple	JJ
cord-001835-0s7ok4uw	1971	7	mutant	mutant	JJ
cord-001835-0s7ok4uw	1971	8	have	have	VBP
cord-001835-0s7ok4uw	1971	9	been	be	VBN
cord-001835-0s7ok4uw	1971	10	determined	determine	VBN
cord-001835-0s7ok4uw	1971	11	by	by	IN
cord-001835-0s7ok4uw	1971	12	aligning	align	VBG
cord-001835-0s7ok4uw	1971	13	and	and	CC
cord-001835-0s7ok4uw	1971	14	transfer	transfer	VB
cord-001835-0s7ok4uw	1971	15	assignments	assignment	NNS
cord-001835-0s7ok4uw	1971	16	of	of	IN
cord-001835-0s7ok4uw	1971	17	the	the	DT
cord-001835-0s7ok4uw	1971	18	WT	WT	NNP
cord-001835-0s7ok4uw	1971	19	KCNE1	KCNE1	NNS
cord-001835-0s7ok4uw	1972	1	previous	previous	JJ
cord-001835-0s7ok4uw	1972	2	determined	determine	VBN
cord-001835-0s7ok4uw	1972	3	in	in	IN
cord-001835-0s7ok4uw	1972	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	1972	5	lab	lab	NN
cord-001835-0s7ok4uw	1972	6	.	.	.
cord-001835-0s7ok4uw	1973	1	With	with	IN
cord-001835-0s7ok4uw	1973	2	the	the	DT
cord-001835-0s7ok4uw	1973	3	structure	structure	NN
cord-001835-0s7ok4uw	1973	4	of	of	IN
cord-001835-0s7ok4uw	1973	5	KCNE1	kcne1	NN
cord-001835-0s7ok4uw	1973	6	triple	triple	JJ
cord-001835-0s7ok4uw	1973	7	mutant	mutant	NN
cord-001835-0s7ok4uw	1973	8	determined	determine	VBN
cord-001835-0s7ok4uw	1973	9	,	,	,
cord-001835-0s7ok4uw	1973	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	1973	11	aim	aim	VBP
cord-001835-0s7ok4uw	1973	12	to	to	TO
cord-001835-0s7ok4uw	1973	13	computationally	computationally	RB
cord-001835-0s7ok4uw	1973	14	dock	dock	VB
cord-001835-0s7ok4uw	1973	15	the	the	DT
cord-001835-0s7ok4uw	1973	16	triple	triple	JJ
cord-001835-0s7ok4uw	1973	17	mutant	mutant	NN
cord-001835-0s7ok4uw	1973	18	into	into	IN
cord-001835-0s7ok4uw	1973	19	a	a	DT
cord-001835-0s7ok4uw	1973	20	model	model	NN
cord-001835-0s7ok4uw	1973	21	of	of	IN
cord-001835-0s7ok4uw	1973	22	the	the	DT
cord-001835-0s7ok4uw	1973	23	full	full	JJ
cord-001835-0s7ok4uw	1973	24	-	-	HYPH
cord-001835-0s7ok4uw	1973	25	length	length	NN
cord-001835-0s7ok4uw	1973	26	KCNQ1	KCNQ1	NNS
cord-001835-0s7ok4uw	1973	27	channel	channel	NN
cord-001835-0s7ok4uw	1973	28	in	in	IN
cord-001835-0s7ok4uw	1973	29	the	the	DT
cord-001835-0s7ok4uw	1973	30	open	open	JJ
cord-001835-0s7ok4uw	1973	31	and	and	CC
cord-001835-0s7ok4uw	1973	32	closed	closed	JJ
cord-001835-0s7ok4uw	1973	33	state	state	NN
cord-001835-0s7ok4uw	1973	34	.	.	.
cord-001835-0s7ok4uw	1974	1	Lastly	lastly	RB
cord-001835-0s7ok4uw	1974	2	,	,	,
cord-001835-0s7ok4uw	1974	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	1974	4	will	will	MD
cord-001835-0s7ok4uw	1974	5	compare	compare	VB
cord-001835-0s7ok4uw	1974	6	the	the	DT
cord-001835-0s7ok4uw	1974	7	known	know	VBN
cord-001835-0s7ok4uw	1974	8	structure	structure	NN
cord-001835-0s7ok4uw	1974	9	of	of	IN
cord-001835-0s7ok4uw	1974	10	KCNE1	kcne1	NN
cord-001835-0s7ok4uw	1974	11	docked	dock	VBN
cord-001835-0s7ok4uw	1974	12	to	to	IN
cord-001835-0s7ok4uw	1974	13	a	a	DT
cord-001835-0s7ok4uw	1974	14	model	model	NN
cord-001835-0s7ok4uw	1974	15	of	of	IN
cord-001835-0s7ok4uw	1974	16	KCNQ1	KCNQ1	NNS
cord-001835-0s7ok4uw	1974	17	to	to	IN
cord-001835-0s7ok4uw	1974	18	that	that	DT
cord-001835-0s7ok4uw	1974	19	of	of	IN
cord-001835-0s7ok4uw	1974	20	the	the	DT
cord-001835-0s7ok4uw	1974	21	KCNE1	kcne1	NN
cord-001835-0s7ok4uw	1974	22	triple	triple	NN
cord-001835-0s7ok4uw	1974	23	mutant	mutant	NN
cord-001835-0s7ok4uw	1974	24	to	to	TO
cord-001835-0s7ok4uw	1974	25	determine	determine	VB
cord-001835-0s7ok4uw	1974	26	key	key	JJ
cord-001835-0s7ok4uw	1974	27	interactions	interaction	NNS
cord-001835-0s7ok4uw	1974	28	,	,	,
cord-001835-0s7ok4uw	1974	29	significant	significant	JJ
cord-001835-0s7ok4uw	1974	30	structural	structural	JJ
cord-001835-0s7ok4uw	1974	31	and	and	CC
cord-001835-0s7ok4uw	1974	32	conformational	conformational	JJ
cord-001835-0s7ok4uw	1974	33	changes	change	NNS
cord-001835-0s7ok4uw	1974	34	,	,	,
cord-001835-0s7ok4uw	1974	35	and	and	CC
cord-001835-0s7ok4uw	1974	36	how	how	WRB
cord-001835-0s7ok4uw	1974	37	the	the	DT
cord-001835-0s7ok4uw	1974	38	triple	triple	JJ
cord-001835-0s7ok4uw	1974	39	motif	motif	NN
cord-001835-0s7ok4uw	1974	40	region	region	NN
cord-001835-0s7ok4uw	1974	41	gives	give	VBZ
cord-001835-0s7ok4uw	1974	42	rise	rise	NN
cord-001835-0s7ok4uw	1974	43	to	to	IN
cord-001835-0s7ok4uw	1974	44	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1974	45	specific	specific	JJ
cord-001835-0s7ok4uw	1974	46	structural	structural	JJ
cord-001835-0s7ok4uw	1974	47	and	and	CC
cord-001835-0s7ok4uw	1974	48	functional	functional	JJ
cord-001835-0s7ok4uw	1974	49	differences	difference	NNS
cord-001835-0s7ok4uw	1974	50	.	.	.
cord-001835-0s7ok4uw	1975	1	With	with	IN
cord-001835-0s7ok4uw	1975	2	this	this	DT
cord-001835-0s7ok4uw	1975	3	information	information	NN
cord-001835-0s7ok4uw	1975	4	,	,	,
cord-001835-0s7ok4uw	1975	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	1975	6	can	can	MD
cord-001835-0s7ok4uw	1975	7	begin	begin	VB
cord-001835-0s7ok4uw	1975	8	to	to	TO
cord-001835-0s7ok4uw	1975	9	understand	understand	VB
cord-001835-0s7ok4uw	1975	10	the	the	DT
cord-001835-0s7ok4uw	1975	11	mechanism	mechanism	NN
cord-001835-0s7ok4uw	1975	12	of	of	IN
cord-001835-0s7ok4uw	1975	13	the	the	DT
cord-001835-0s7ok4uw	1975	14	functional	functional	JJ
cord-001835-0s7ok4uw	1975	15	diversity	diversity	NN
cord-001835-0s7ok4uw	1975	16	of	of	IN
cord-001835-0s7ok4uw	1975	17	the	the	DT
cord-001835-0s7ok4uw	1975	18	KCNE	KCNE	NNP
cord-001835-0s7ok4uw	1975	19	family	family	NN
cord-001835-0s7ok4uw	1975	20	on	on	IN
cord-001835-0s7ok4uw	1975	21	KCNQ1	KCNQ1	NNP
cord-001835-0s7ok4uw	1975	22	potassium	potassium	NN
cord-001835-0s7ok4uw	1975	23	channel	channel	NN
cord-001835-0s7ok4uw	1975	24	.	.	.
cord-001835-0s7ok4uw	1976	1	Biochemical	biochemical	JJ
cord-001835-0s7ok4uw	1976	2	characterization	characterization	NN
cord-001835-0s7ok4uw	1976	3	of	of	IN
cord-001835-0s7ok4uw	1976	4	Brassica	Brassica	NNP
cord-001835-0s7ok4uw	1976	5	napus	napus	NNP
cord-001835-0s7ok4uw	1976	6	diacylglycerol	diacylglycerol	NNP
cord-001835-0s7ok4uw	1976	7	acyltransferase	acyltransferase	NNP
cord-001835-0s7ok4uw	1976	8	1	1	CD
cord-001835-0s7ok4uw	1976	9	and	and	CC
cord-001835-0s7ok4uw	1976	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1976	11	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	1976	12	domain	domain	NN
cord-001835-0s7ok4uw	1976	13	.a	.a	.
cord-001835-0s7ok4uw	1976	14	)	)	-RRB-
cord-001835-0s7ok4uw	1976	15	expressed	express	VBD
cord-001835-0s7ok4uw	1976	16	in	in	IN
cord-001835-0s7ok4uw	1976	17	Saccharomyces	Saccharomyces	NNP
cord-001835-0s7ok4uw	1976	18	cerevisiae	cerevisiae	NNS
cord-001835-0s7ok4uw	1976	19	.	.	.
cord-001835-0s7ok4uw	1977	1	Purified	purify	VBN
cord-001835-0s7ok4uw	1977	2	BnaDGAT1	BnaDGAT1	NNP
cord-001835-0s7ok4uw	1977	3	in	in	IN
cord-001835-0s7ok4uw	1977	4	n	n	JJ
cord-001835-0s7ok4uw	1977	5	-	-	HYPH
cord-001835-0s7ok4uw	1977	6	dodecyl	dodecyl	NNP
cord-001835-0s7ok4uw	1977	7	-	-	HYPH
cord-001835-0s7ok4uw	1977	8	b	b	NN
cord-001835-0s7ok4uw	1977	9	-	-	HYPH
cord-001835-0s7ok4uw	1977	10	D	d	NN
cord-001835-0s7ok4uw	1977	11	-	-	HYPH
cord-001835-0s7ok4uw	1977	12	maltopyranoside	maltopyranoside	NN
cord-001835-0s7ok4uw	1977	13	(	(	-LRB-
cord-001835-0s7ok4uw	1977	14	DDM	DDM	NNP
cord-001835-0s7ok4uw	1977	15	)	)	-RRB-
cord-001835-0s7ok4uw	1977	16	micelles	micelle	NNS
cord-001835-0s7ok4uw	1977	17	behaves	behave	VBZ
cord-001835-0s7ok4uw	1977	18	as	as	IN
cord-001835-0s7ok4uw	1977	19	dimers	dimer	NNS
cord-001835-0s7ok4uw	1977	20	,	,	,
cord-001835-0s7ok4uw	1977	21	which	which	WDT
cord-001835-0s7ok4uw	1977	22	can	can	MD
cord-001835-0s7ok4uw	1977	23	associate	associate	VB
cord-001835-0s7ok4uw	1977	24	further	further	RB
cord-001835-0s7ok4uw	1977	25	to	to	TO
cord-001835-0s7ok4uw	1977	26	form	form	VB
cord-001835-0s7ok4uw	1977	27	tetramers	tetramer	NNS
cord-001835-0s7ok4uw	1977	28	.	.	.
cord-001835-0s7ok4uw	1978	1	The	the	DT
cord-001835-0s7ok4uw	1978	2	acyl	acyl	NN
cord-001835-0s7ok4uw	1978	3	donor	donor	NN
cord-001835-0s7ok4uw	1978	4	preference	preference	NN
cord-001835-0s7ok4uw	1978	5	of	of	IN
cord-001835-0s7ok4uw	1978	6	the	the	DT
cord-001835-0s7ok4uw	1978	7	major	major	JJ
cord-001835-0s7ok4uw	1978	8	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	1978	9	form	form	NN
cord-001835-0s7ok4uw	1978	10	with	with	IN
cord-001835-0s7ok4uw	1978	11	sn-1,2-diolein	sn-1,2-diolein	NNP
cord-001835-0s7ok4uw	1978	12	as	as	IN
cord-001835-0s7ok4uw	1978	13	acceptor	acceptor	NN
cord-001835-0s7ok4uw	1978	14	follows	follow	VBZ
cord-001835-0s7ok4uw	1978	15	the	the	DT
cord-001835-0s7ok4uw	1978	16	following	following	JJ
cord-001835-0s7ok4uw	1978	17	order	order	NN
cord-001835-0s7ok4uw	1978	18	:	:	:
cord-001835-0s7ok4uw	1978	19	a	a	LS
cord-001835-0s7ok4uw	1978	20	-	-	HYPH
cord-001835-0s7ok4uw	1978	21	linolenoyl	linolenoyl	NNP
cord-001835-0s7ok4uw	1978	22	-	-	HYPH
cord-001835-0s7ok4uw	1978	23	CoA	CoA	NNP
cord-001835-0s7ok4uw	1978	24	>	>	XX
cord-001835-0s7ok4uw	1978	25	oleoyl	oleoyl	NNP
cord-001835-0s7ok4uw	1978	26	-	-	HYPH
cord-001835-0s7ok4uw	1978	27	CoA	CoA	NNP
cord-001835-0s7ok4uw	1978	28	5	5	CD
cord-001835-0s7ok4uw	1978	29	palmitoyl	palmitoyl	JJ
cord-001835-0s7ok4uw	1978	30	-	-	HYPH
cord-001835-0s7ok4uw	1978	31	CoA	coa	NN
cord-001835-0s7ok4uw	1978	32	>	>	XX
cord-001835-0s7ok4uw	1978	33	linoleoyl	linoleoyl	JJ
cord-001835-0s7ok4uw	1978	34	-	-	HYPH
cord-001835-0s7ok4uw	1978	35	CoA	coa	NN
cord-001835-0s7ok4uw	1978	36	>	>	XX
cord-001835-0s7ok4uw	1979	1	stearoyl	stearoyl	NNP
cord-001835-0s7ok4uw	1979	2	-	-	HYPH
cord-001835-0s7ok4uw	1979	3	CoA.	CoA.	NNP
cord-001835-0s7ok4uw	1980	1	The	the	DT
cord-001835-0s7ok4uw	1980	2	first	first	JJ
cord-001835-0s7ok4uw	1980	3	113	113	CD
cord-001835-0s7ok4uw	1980	4	residues	residue	NNS
cord-001835-0s7ok4uw	1980	5	of	of	IN
cord-001835-0s7ok4uw	1980	6	BnaC.DG	BnaC.DG	NNP
cord-001835-0s7ok4uw	1980	7	-	-	:
cord-001835-0s7ok4uw	1980	8	AT1.a	AT1.a	NNP
cord-001835-0s7ok4uw	1980	9	corresponding	correspond	VBG
cord-001835-0s7ok4uw	1980	10	to	to	IN
cord-001835-0s7ok4uw	1980	11	a	a	DT
cord-001835-0s7ok4uw	1980	12	soluble	soluble	JJ
cord-001835-0s7ok4uw	1980	13	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	1980	14	region	region	NN
cord-001835-0s7ok4uw	1980	15	was	be	VBD
cord-001835-0s7ok4uw	1980	16	expressed	express	VBN
cord-001835-0s7ok4uw	1980	17	in	in	IN
cord-001835-0s7ok4uw	1980	18	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	1980	19	coli	coli	NNS
cord-001835-0s7ok4uw	1980	20	and	and	CC
cord-001835-0s7ok4uw	1980	21	purified	purify	VBN
cord-001835-0s7ok4uw	1980	22	.	.	.
cord-001835-0s7ok4uw	1981	1	Truncation	truncation	NN
cord-001835-0s7ok4uw	1981	2	of	of	IN
cord-001835-0s7ok4uw	1981	3	this	this	DT
cord-001835-0s7ok4uw	1981	4	soluble	soluble	JJ
cord-001835-0s7ok4uw	1981	5	domain	domain	NN
cord-001835-0s7ok4uw	1981	6	reveals	reveal	VBZ
cord-001835-0s7ok4uw	1981	7	that	that	IN
cord-001835-0s7ok4uw	1981	8	the	the	DT
cord-001835-0s7ok4uw	1981	9	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	1981	10	interface	interface	NN
cord-001835-0s7ok4uw	1981	11	is	be	VBZ
cord-001835-0s7ok4uw	1981	12	located	locate	VBN
cord-001835-0s7ok4uw	1981	13	within	within	IN
cord-001835-0s7ok4uw	1981	14	residues	residue	NNS
cord-001835-0s7ok4uw	1981	15	49	49	CD
cord-001835-0s7ok4uw	1981	16	-	-	SYM
cord-001835-0s7ok4uw	1981	17	113	113	CD
cord-001835-0s7ok4uw	1981	18	,	,	,
cord-001835-0s7ok4uw	1981	19	while	while	IN
cord-001835-0s7ok4uw	1981	20	the	the	DT
cord-001835-0s7ok4uw	1981	21	first	first	JJ
cord-001835-0s7ok4uw	1981	22	48	48	CD
cord-001835-0s7ok4uw	1981	23	residues	residue	NNS
cord-001835-0s7ok4uw	1981	24	allow	allow	VBP
cord-001835-0s7ok4uw	1981	25	formation	formation	NN
cord-001835-0s7ok4uw	1981	26	of	of	IN
cord-001835-0s7ok4uw	1981	27	tetramers	tetramer	NNS
cord-001835-0s7ok4uw	1981	28	.	.	.
cord-001835-0s7ok4uw	1982	1	This	this	DT
cord-001835-0s7ok4uw	1982	2	N	n	CD
cord-001835-0s7ok4uw	1982	3	-	-	HYPH
cord-001835-0s7ok4uw	1982	4	terminal	terminal	NN
cord-001835-0s7ok4uw	1982	5	region	region	NN
cord-001835-0s7ok4uw	1982	6	was	be	VBD
cord-001835-0s7ok4uw	1982	7	implicated	implicate	VBN
cord-001835-0s7ok4uw	1982	8	as	as	IN
cord-001835-0s7ok4uw	1982	9	an	an	DT
cord-001835-0s7ok4uw	1982	10	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	1982	11	exosite	exosite	NN
cord-001835-0s7ok4uw	1982	12	for	for	IN
cord-001835-0s7ok4uw	1982	13	acyl	acyl	NNP
cord-001835-0s7ok4uw	1982	14	-	-	HYPH
cord-001835-0s7ok4uw	1982	15	CoAs	CoAs	NNP
cord-001835-0s7ok4uw	1982	16	as	as	IN
cord-001835-0s7ok4uw	1982	17	revealed	reveal	VBN
cord-001835-0s7ok4uw	1982	18	by	by	IN
cord-001835-0s7ok4uw	1982	19	previous	previous	JJ
cord-001835-0s7ok4uw	1982	20	Lipidex-1000	Lipidex-1000	NNP
cord-001835-0s7ok4uw	1982	21	binding	binding	NN
cord-001835-0s7ok4uw	1982	22	studies	study	NNS
cord-001835-0s7ok4uw	1982	23	.	.	.
cord-001835-0s7ok4uw	1983	1	In	in	IN
cord-001835-0s7ok4uw	1983	2	the	the	DT
cord-001835-0s7ok4uw	1983	3	current	current	JJ
cord-001835-0s7ok4uw	1983	4	study	study	NN
cord-001835-0s7ok4uw	1983	5	,	,	,
cord-001835-0s7ok4uw	1983	6	circular	circular	JJ
cord-001835-0s7ok4uw	1983	7	dichroism	dichroism	NN
cord-001835-0s7ok4uw	1983	8	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	1983	9	and	and	CC
cord-001835-0s7ok4uw	1983	10	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	1983	11	titration	titration	NN
cord-001835-0s7ok4uw	1983	12	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	1983	13	were	be	VBD
cord-001835-0s7ok4uw	1983	14	used	use	VBN
cord-001835-0s7ok4uw	1983	15	to	to	TO
cord-001835-0s7ok4uw	1983	16	probe	probe	VB
cord-001835-0s7ok4uw	1983	17	the	the	DT
cord-001835-0s7ok4uw	1983	18	binding	bind	VBG
cord-001835-0s7ok4uw	1983	19	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	1983	20	and	and	CC
cord-001835-0s7ok4uw	1983	21	thermodynamics	thermodynamic	NNS
cord-001835-0s7ok4uw	1983	22	.	.	.
cord-001835-0s7ok4uw	1984	1	DGAT1	DGAT1	NNP
cord-001835-0s7ok4uw	1984	2	appears	appear	VBZ
cord-001835-0s7ok4uw	1984	3	to	to	TO
cord-001835-0s7ok4uw	1984	4	shift	shift	VB
cord-001835-0s7ok4uw	1984	5	between	between	IN
cord-001835-0s7ok4uw	1984	6	two	two	CD
cord-001835-0s7ok4uw	1984	7	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	1984	8	states	state	NNS
cord-001835-0s7ok4uw	1984	9	,	,	,
cord-001835-0s7ok4uw	1984	10	a	a	DT
cord-001835-0s7ok4uw	1984	11	phenomenon	phenomenon	NN
cord-001835-0s7ok4uw	1984	12	that	that	WDT
cord-001835-0s7ok4uw	1984	13	may	may	MD
cord-001835-0s7ok4uw	1984	14	be	be	VB
cord-001835-0s7ok4uw	1984	15	related	relate	VBN
cord-001835-0s7ok4uw	1984	16	to	to	IN
cord-001835-0s7ok4uw	1984	17	regulation	regulation	NN
cord-001835-0s7ok4uw	1984	18	of	of	IN
cord-001835-0s7ok4uw	1984	19	enzyme	enzyme	NN
cord-001835-0s7ok4uw	1984	20	activity	activity	NN
cord-001835-0s7ok4uw	1984	21	and	and	CC
cord-001835-0s7ok4uw	1984	22	mediated	mediate	VBN
cord-001835-0s7ok4uw	1984	23	by	by	IN
cord-001835-0s7ok4uw	1984	24	the	the	DT
cord-001835-0s7ok4uw	1984	25	N	n	CD
cord-001835-0s7ok4uw	1984	26	-	-	HYPH
cord-001835-0s7ok4uw	1984	27	terminal	terminal	NN
cord-001835-0s7ok4uw	1984	28	domain	domain	NN
cord-001835-0s7ok4uw	1984	29	.	.	.
cord-001835-0s7ok4uw	1985	1	Alteration	alteration	NN
cord-001835-0s7ok4uw	1985	2	of	of	IN
cord-001835-0s7ok4uw	1985	3	lysine	lysine	NN
cord-001835-0s7ok4uw	1985	4	and	and	CC
cord-001835-0s7ok4uw	1985	5	arginine	arginine	NN
cord-001835-0s7ok4uw	1985	6	content	content	NN
cord-001835-0s7ok4uw	1985	7	as	as	IN
cord-001835-0s7ok4uw	1985	8	a	a	DT
cord-001835-0s7ok4uw	1985	9	strategy	strategy	NN
cord-001835-0s7ok4uw	1985	10	to	to	TO
cord-001835-0s7ok4uw	1985	11	modify	modify	VB
cord-001835-0s7ok4uw	1985	12	Such	such	PDT
cord-001835-0s7ok4uw	1985	13	an	an	DT
cord-001835-0s7ok4uw	1985	14	interaction	interaction	NN
cord-001835-0s7ok4uw	1985	15	was	be	VBD
cord-001835-0s7ok4uw	1985	16	found	find	VBN
cord-001835-0s7ok4uw	1985	17	to	to	TO
cord-001835-0s7ok4uw	1985	18	increase	increase	VB
cord-001835-0s7ok4uw	1985	19	the	the	DT
cord-001835-0s7ok4uw	1985	20	activity	activity	NN
cord-001835-0s7ok4uw	1985	21	of	of	IN
cord-001835-0s7ok4uw	1985	22	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1985	23	in	in	IN
cord-001835-0s7ok4uw	1985	24	vitro	vitro	FW
cord-001835-0s7ok4uw	1985	25	.	.	.
cord-001835-0s7ok4uw	1986	1	Further	further	RB
cord-001835-0s7ok4uw	1986	2	,	,	,
cord-001835-0s7ok4uw	1986	3	deletion	deletion	NN
cord-001835-0s7ok4uw	1986	4	of	of	IN
cord-001835-0s7ok4uw	1986	5	C	c	NN
cord-001835-0s7ok4uw	1986	6	terminal	terminal	NN
cord-001835-0s7ok4uw	1986	7	43	43	CD
cord-001835-0s7ok4uw	1986	8	amino	amino	NN
cord-001835-0s7ok4uw	1986	9	acid	acid	NN
cord-001835-0s7ok4uw	1986	10	residues	residue	NNS
cord-001835-0s7ok4uw	1986	11	also	also	RB
cord-001835-0s7ok4uw	1986	12	resulted	result	VBD
cord-001835-0s7ok4uw	1986	13	in	in	IN
cord-001835-0s7ok4uw	1986	14	increase	increase	NN
cord-001835-0s7ok4uw	1986	15	in	in	IN
cord-001835-0s7ok4uw	1986	16	the	the	DT
cord-001835-0s7ok4uw	1986	17	polymerase	polymerase	NN
cord-001835-0s7ok4uw	1986	18	activity	activity	NN
cord-001835-0s7ok4uw	1986	19	that	that	WDT
cord-001835-0s7ok4uw	1986	20	was	be	VBD
cord-001835-0s7ok4uw	1986	21	comparable	comparable	JJ
cord-001835-0s7ok4uw	1986	22	to	to	IN
cord-001835-0s7ok4uw	1986	23	the	the	DT
cord-001835-0s7ok4uw	1986	24	full	full	JJ
cord-001835-0s7ok4uw	1986	25	length	length	NN
cord-001835-0s7ok4uw	1986	26	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1986	27	-	-	HYPH
cord-001835-0s7ok4uw	1986	28	P10	P10	NNP
cord-001835-0s7ok4uw	1986	29	complex	complex	NN
cord-001835-0s7ok4uw	1986	30	.	.	.
cord-001835-0s7ok4uw	1987	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	1987	2	was	be	VBD
cord-001835-0s7ok4uw	1987	3	proposed	propose	VBN
cord-001835-0s7ok4uw	1987	4	that	that	IN
cord-001835-0s7ok4uw	1987	5	the	the	DT
cord-001835-0s7ok4uw	1987	6	conserved	conserve	VBN
cord-001835-0s7ok4uw	1987	7	C	C	NNP
cord-001835-0s7ok4uw	1987	8	terminal	terminal	NN
cord-001835-0s7ok4uw	1987	9	disordered	disordered	JJ
cord-001835-0s7ok4uw	1987	10	domain	domain	NN
cord-001835-0s7ok4uw	1987	11	of	of	IN
cord-001835-0s7ok4uw	1987	12	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1987	13	was	be	VBD
cord-001835-0s7ok4uw	1987	14	responsible	responsible	JJ
cord-001835-0s7ok4uw	1987	15	for	for	IN
cord-001835-0s7ok4uw	1987	16	interaction	interaction	NN
cord-001835-0s7ok4uw	1987	17	with	with	IN
cord-001835-0s7ok4uw	1987	18	P10	p10	NN
cord-001835-0s7ok4uw	1987	19	and	and	CC
cord-001835-0s7ok4uw	1987	20	modulation	modulation	NN
cord-001835-0s7ok4uw	1987	21	of	of	IN
cord-001835-0s7ok4uw	1987	22	the	the	DT
cord-001835-0s7ok4uw	1987	23	activity	activity	NN
cord-001835-0s7ok4uw	1987	24	.	.	.
cord-001835-0s7ok4uw	1988	1	In	in	IN
cord-001835-0s7ok4uw	1988	2	the	the	DT
cord-001835-0s7ok4uw	1988	3	present	present	JJ
cord-001835-0s7ok4uw	1988	4	study	study	NN
cord-001835-0s7ok4uw	1988	5	,	,	,
cord-001835-0s7ok4uw	1988	6	role	role	NN
cord-001835-0s7ok4uw	1988	7	of	of	IN
cord-001835-0s7ok4uw	1988	8	the	the	DT
cord-001835-0s7ok4uw	1988	9	C	C	NNP
cord-001835-0s7ok4uw	1988	10	terminal	terminal	NN
cord-001835-0s7ok4uw	1988	11	disordered	disordered	JJ
cord-001835-0s7ok4uw	1988	12	domain	domain	NN
cord-001835-0s7ok4uw	1988	13	was	be	VBD
cord-001835-0s7ok4uw	1988	14	further	further	RB
cord-001835-0s7ok4uw	1988	15	investigated	investigate	VBN
cord-001835-0s7ok4uw	1988	16	by	by	IN
cord-001835-0s7ok4uw	1988	17	determining	determine	VBG
cord-001835-0s7ok4uw	1988	18	the	the	DT
cord-001835-0s7ok4uw	1988	19	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	1988	20	status	status	NN
cord-001835-0s7ok4uw	1988	21	of	of	IN
cord-001835-0s7ok4uw	1988	22	the	the	DT
cord-001835-0s7ok4uw	1988	23	complex	complex	NN
cord-001835-0s7ok4uw	1988	24	and	and	CC
cord-001835-0s7ok4uw	1988	25	the	the	DT
cord-001835-0s7ok4uw	1988	26	C	C	NNP
cord-001835-0s7ok4uw	1988	27	terminal	terminal	NN
cord-001835-0s7ok4uw	1988	28	deletion	deletion	NN
cord-001835-0s7ok4uw	1988	29	mutants	mutant	NNS
cord-001835-0s7ok4uw	1988	30	of	of	IN
cord-001835-0s7ok4uw	1988	31	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1988	32	and	and	CC
cord-001835-0s7ok4uw	1988	33	also	also	RB
cord-001835-0s7ok4uw	1988	34	by	by	IN
cord-001835-0s7ok4uw	1988	35	quantitating	quantitate	VBG
cord-001835-0s7ok4uw	1988	36	the	the	DT
cord-001835-0s7ok4uw	1988	37	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1988	38	-	-	HYPH
cord-001835-0s7ok4uw	1988	39	P10	p10	NN
cord-001835-0s7ok4uw	1988	40	interaction	interaction	NN
cord-001835-0s7ok4uw	1988	41	using	use	VBG
cord-001835-0s7ok4uw	1988	42	surface	surface	NN
cord-001835-0s7ok4uw	1988	43	plasmon	plasmon	JJ
cord-001835-0s7ok4uw	1988	44	resonance	resonance	NN
cord-001835-0s7ok4uw	1988	45	.	.	.
cord-001835-0s7ok4uw	1989	1	Size	size	NN
cord-001835-0s7ok4uw	1989	2	exclusion	exclusion	NN
cord-001835-0s7ok4uw	1989	3	chromatography	chromatography	NN
cord-001835-0s7ok4uw	1989	4	revealed	reveal	VBD
cord-001835-0s7ok4uw	1989	5	that	that	IN
cord-001835-0s7ok4uw	1989	6	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1989	7	eluted	elute	VBD
cord-001835-0s7ok4uw	1989	8	in	in	IN
cord-001835-0s7ok4uw	1989	9	the	the	DT
cord-001835-0s7ok4uw	1989	10	void	void	JJ
cord-001835-0s7ok4uw	1989	11	volume	volume	NN
cord-001835-0s7ok4uw	1989	12	of	of	IN
cord-001835-0s7ok4uw	1989	13	the	the	DT
cord-001835-0s7ok4uw	1989	14	column	column	NN
cord-001835-0s7ok4uw	1989	15	whereas	whereas	IN
cord-001835-0s7ok4uw	1989	16	a	a	DT
cord-001835-0s7ok4uw	1989	17	significant	significant	JJ
cord-001835-0s7ok4uw	1989	18	fraction	fraction	NN
cord-001835-0s7ok4uw	1989	19	of	of	IN
cord-001835-0s7ok4uw	1989	20	the	the	DT
cord-001835-0s7ok4uw	1989	21	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1989	22	-	-	HYPH
cord-001835-0s7ok4uw	1989	23	P10	P10	NNP
cord-001835-0s7ok4uw	1989	24	complex	complex	NN
cord-001835-0s7ok4uw	1989	25	eluted	elute	VBN
cord-001835-0s7ok4uw	1989	26	at	at	IN
cord-001835-0s7ok4uw	1989	27	a	a	DT
cord-001835-0s7ok4uw	1989	28	position	position	NN
cord-001835-0s7ok4uw	1989	29	corresponding	correspond	VBG
cord-001835-0s7ok4uw	1989	30	to	to	IN
cord-001835-0s7ok4uw	1989	31	the	the	DT
cord-001835-0s7ok4uw	1989	32	size	size	NN
cord-001835-0s7ok4uw	1989	33	of	of	IN
cord-001835-0s7ok4uw	1989	34	the	the	DT
cord-001835-0s7ok4uw	1989	35	1:1	1:1	CD
cord-001835-0s7ok4uw	1989	36	complex	complex	NN
cord-001835-0s7ok4uw	1989	37	of	of	IN
cord-001835-0s7ok4uw	1989	38	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1989	39	and	and	CC
cord-001835-0s7ok4uw	1989	40	P10	P10	NNP
cord-001835-0s7ok4uw	1989	41	(	(	-LRB-
cord-001835-0s7ok4uw	1989	42	77KDa	77kda	CD
cord-001835-0s7ok4uw	1989	43	)	)	-RRB-
cord-001835-0s7ok4uw	1989	44	.	.	.
cord-001835-0s7ok4uw	1990	1	Activity	activity	NN
cord-001835-0s7ok4uw	1990	2	measurements	measurement	NNS
cord-001835-0s7ok4uw	1990	3	indicated	indicate	VBD
cord-001835-0s7ok4uw	1990	4	that	that	IN
cord-001835-0s7ok4uw	1990	5	the	the	DT
cord-001835-0s7ok4uw	1990	6	heterodimeric	heterodimeric	JJ
cord-001835-0s7ok4uw	1990	7	complex	complex	NN
cord-001835-0s7ok4uw	1990	8	was	be	VBD
cord-001835-0s7ok4uw	1990	9	more	more	RBR
cord-001835-0s7ok4uw	1990	10	active	active	JJ
cord-001835-0s7ok4uw	1990	11	than	than	IN
cord-001835-0s7ok4uw	1990	12	the	the	DT
cord-001835-0s7ok4uw	1990	13	aggregate	aggregate	NN
cord-001835-0s7ok4uw	1990	14	eluting	elute	VBG
cord-001835-0s7ok4uw	1990	15	in	in	IN
cord-001835-0s7ok4uw	1990	16	the	the	DT
cord-001835-0s7ok4uw	1990	17	void	void	JJ
cord-001835-0s7ok4uw	1990	18	fraction	fraction	NN
cord-001835-0s7ok4uw	1990	19	.	.	.
cord-001835-0s7ok4uw	1991	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	1991	2	,	,	,
cord-001835-0s7ok4uw	1991	3	the	the	DT
cord-001835-0s7ok4uw	1991	4	C	C	NNP
cord-001835-0s7ok4uw	1991	5	terminal	terminal	NN
cord-001835-0s7ok4uw	1991	6	deletion	deletion	NN
cord-001835-0s7ok4uw	1991	7	mutants	mutant	NNS
cord-001835-0s7ok4uw	1991	8	of	of	IN
cord-001835-0s7ok4uw	1991	9	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1992	1	(	(	-LRB-
cord-001835-0s7ok4uw	1992	2	C	C	NNP
cord-001835-0s7ok4uw	1992	3	del	del	NNP
cord-001835-0s7ok4uw	1992	4	43	43	CD
cord-001835-0s7ok4uw	1992	5	&	&	CC
cord-001835-0s7ok4uw	1992	6	C	C	NNP
cord-001835-0s7ok4uw	1992	7	del	del	NNP
cord-001835-0s7ok4uw	1992	8	72	72	CD
cord-001835-0s7ok4uw	1992	9	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1992	10	)	)	-RRB-
cord-001835-0s7ok4uw	1992	11	were	be	VBD
cord-001835-0s7ok4uw	1992	12	also	also	RB
cord-001835-0s7ok4uw	1992	13	found	find	VBN
cord-001835-0s7ok4uw	1992	14	to	to	TO
cord-001835-0s7ok4uw	1992	15	be	be	VB
cord-001835-0s7ok4uw	1992	16	less	less	RBR
cord-001835-0s7ok4uw	1992	17	aggregated	aggregate	VBN
cord-001835-0s7ok4uw	1992	18	as	as	IN
cord-001835-0s7ok4uw	1992	19	compared	compare	VBN
cord-001835-0s7ok4uw	1992	20	to	to	IN
cord-001835-0s7ok4uw	1992	21	full	full	JJ
cord-001835-0s7ok4uw	1992	22	length	length	NN
cord-001835-0s7ok4uw	1992	23	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1992	24	and	and	CC
cord-001835-0s7ok4uw	1992	25	some	some	DT
cord-001835-0s7ok4uw	1992	26	of	of	IN
cord-001835-0s7ok4uw	1992	27	the	the	DT
cord-001835-0s7ok4uw	1992	28	protein	protein	NN
cord-001835-0s7ok4uw	1992	29	eluted	elute	VBN
cord-001835-0s7ok4uw	1992	30	at	at	IN
cord-001835-0s7ok4uw	1992	31	a	a	DT
cord-001835-0s7ok4uw	1992	32	position	position	NN
cord-001835-0s7ok4uw	1992	33	corresponding	correspond	VBG
cord-001835-0s7ok4uw	1992	34	to	to	IN
cord-001835-0s7ok4uw	1992	35	the	the	DT
cord-001835-0s7ok4uw	1992	36	respective	respective	JJ
cord-001835-0s7ok4uw	1992	37	monomers	monomer	NNS
cord-001835-0s7ok4uw	1992	38	.	.	.
cord-001835-0s7ok4uw	1993	1	These	these	DT
cord-001835-0s7ok4uw	1993	2	monomers	monomer	NNS
cord-001835-0s7ok4uw	1993	3	were	be	VBD
cord-001835-0s7ok4uw	1993	4	also	also	RB
cord-001835-0s7ok4uw	1993	5	more	more	RBR
cord-001835-0s7ok4uw	1993	6	active	active	JJ
cord-001835-0s7ok4uw	1993	7	than	than	IN
cord-001835-0s7ok4uw	1993	8	the	the	DT
cord-001835-0s7ok4uw	1993	9	aggregate	aggregate	JJ
cord-001835-0s7ok4uw	1993	10	fractions	fraction	NNS
cord-001835-0s7ok4uw	1993	11	.	.	.
cord-001835-0s7ok4uw	1994	1	These	these	DT
cord-001835-0s7ok4uw	1994	2	results	result	NNS
cord-001835-0s7ok4uw	1994	3	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	1994	4	that	that	IN
cord-001835-0s7ok4uw	1994	5	the	the	DT
cord-001835-0s7ok4uw	1994	6	increase	increase	NN
cord-001835-0s7ok4uw	1994	7	in	in	IN
cord-001835-0s7ok4uw	1994	8	activity	activity	NN
cord-001835-0s7ok4uw	1994	9	observed	observe	VBN
cord-001835-0s7ok4uw	1994	10	either	either	CC
cord-001835-0s7ok4uw	1994	11	upon	upon	IN
cord-001835-0s7ok4uw	1994	12	interaction	interaction	NN
cord-001835-0s7ok4uw	1994	13	with	with	IN
cord-001835-0s7ok4uw	1994	14	P10	p10	NN
cord-001835-0s7ok4uw	1994	15	or	or	CC
cord-001835-0s7ok4uw	1994	16	deletion	deletion	NN
cord-001835-0s7ok4uw	1994	17	of	of	IN
cord-001835-0s7ok4uw	1994	18	the	the	DT
cord-001835-0s7ok4uw	1994	19	C	C	NNP
cord-001835-0s7ok4uw	1994	20	terminal	terminal	NN
cord-001835-0s7ok4uw	1994	21	domain	domain	NN
cord-001835-0s7ok4uw	1994	22	could	could	MD
cord-001835-0s7ok4uw	1994	23	be	be	VB
cord-001835-0s7ok4uw	1994	24	due	due	JJ
cord-001835-0s7ok4uw	1994	25	to	to	IN
cord-001835-0s7ok4uw	1994	26	the	the	DT
cord-001835-0s7ok4uw	1994	27	change	change	NN
cord-001835-0s7ok4uw	1994	28	in	in	IN
cord-001835-0s7ok4uw	1994	29	the	the	DT
cord-001835-0s7ok4uw	1994	30	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	1994	31	state	state	NN
cord-001835-0s7ok4uw	1994	32	of	of	IN
cord-001835-0s7ok4uw	1994	33	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1994	34	.	.	.
cord-001835-0s7ok4uw	1995	1	In	in	IN
cord-001835-0s7ok4uw	1995	2	order	order	NN
cord-001835-0s7ok4uw	1995	3	to	to	TO
cord-001835-0s7ok4uw	1995	4	further	further	RB
cord-001835-0s7ok4uw	1995	5	analyze	analyze	VB
cord-001835-0s7ok4uw	1995	6	the	the	DT
cord-001835-0s7ok4uw	1995	7	interaction	interaction	NN
cord-001835-0s7ok4uw	1995	8	of	of	IN
cord-001835-0s7ok4uw	1995	9	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1995	10	with	with	IN
cord-001835-0s7ok4uw	1995	11	P10	P10	NNP
cord-001835-0s7ok4uw	1995	12	surface	surface	NN
cord-001835-0s7ok4uw	1995	13	plasmon	plasmon	JJ
cord-001835-0s7ok4uw	1995	14	resonance	resonance	NN
cord-001835-0s7ok4uw	1995	15	was	be	VBD
cord-001835-0s7ok4uw	1995	16	used	use	VBN
cord-001835-0s7ok4uw	1995	17	.	.	.
cord-001835-0s7ok4uw	1996	1	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1996	2	and	and	CC
cord-001835-0s7ok4uw	1996	3	its	-PRON-	PRP$
cord-001835-0s7ok4uw	1996	4	deletion	deletion	NN
cord-001835-0s7ok4uw	1996	5	mutants	mutant	NNS
cord-001835-0s7ok4uw	1996	6	were	be	VBD
cord-001835-0s7ok4uw	1996	7	immobilized	immobilize	VBN
cord-001835-0s7ok4uw	1996	8	on	on	IN
cord-001835-0s7ok4uw	1996	9	Biacore	Biacore	NNP
cord-001835-0s7ok4uw	1996	10	sensor	sensor	NN
cord-001835-0s7ok4uw	1996	11	surface	surface	NN
cord-001835-0s7ok4uw	1996	12	and	and	CC
cord-001835-0s7ok4uw	1996	13	P10	P10	NNP
cord-001835-0s7ok4uw	1996	14	protein	protein	NN
cord-001835-0s7ok4uw	1996	15	was	be	VBD
cord-001835-0s7ok4uw	1996	16	used	use	VBN
cord-001835-0s7ok4uw	1996	17	as	as	IN
cord-001835-0s7ok4uw	1996	18	an	an	DT
cord-001835-0s7ok4uw	1996	19	analyte	analyte	NN
cord-001835-0s7ok4uw	1996	20	.	.	.
cord-001835-0s7ok4uw	1997	1	Full	full	JJ
cord-001835-0s7ok4uw	1997	2	length	length	NN
cord-001835-0s7ok4uw	1997	3	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1997	4	and	and	CC
cord-001835-0s7ok4uw	1997	5	C	C	NNP
cord-001835-0s7ok4uw	1997	6	del	del	NNP
cord-001835-0s7ok4uw	1997	7	43	43	CD
cord-001835-0s7ok4uw	1997	8	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1997	9	were	be	VBD
cord-001835-0s7ok4uw	1997	10	shown	show	VBN
cord-001835-0s7ok4uw	1997	11	to	to	TO
cord-001835-0s7ok4uw	1997	12	interact	interact	VB
cord-001835-0s7ok4uw	1997	13	with	with	IN
cord-001835-0s7ok4uw	1997	14	P10	P10	NNP
cord-001835-0s7ok4uw	1997	15	with	with	IN
cord-001835-0s7ok4uw	1997	16	KD	KD	NNP
cord-001835-0s7ok4uw	1997	17	values	value	NNS
cord-001835-0s7ok4uw	1997	18	of	of	IN
cord-001835-0s7ok4uw	1997	19	0.6	0.6	CD
cord-001835-0s7ok4uw	1997	20	and	and	CC
cord-001835-0s7ok4uw	1997	21	1	1	CD
cord-001835-0s7ok4uw	1997	22	uM	um	UH
cord-001835-0s7ok4uw	1997	23	respectively	respectively	RB
cord-001835-0s7ok4uw	1997	24	.	.	.
cord-001835-0s7ok4uw	1998	1	However	however	RB
cord-001835-0s7ok4uw	1998	2	,	,	,
cord-001835-0s7ok4uw	1998	3	C	C	NNP
cord-001835-0s7ok4uw	1998	4	del	del	NNP
cord-001835-0s7ok4uw	1998	5	72	72	CD
cord-001835-0s7ok4uw	1998	6	and	and	CC
cord-001835-0s7ok4uw	1998	7	C	C	NNP
cord-001835-0s7ok4uw	1998	8	del	del	NNP
cord-001835-0s7ok4uw	1998	9	85	85	CD
cord-001835-0s7ok4uw	1998	10	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1998	11	did	do	VBD
cord-001835-0s7ok4uw	1998	12	not	not	RB
cord-001835-0s7ok4uw	1998	13	show	show	VB
cord-001835-0s7ok4uw	1998	14	any	any	DT
cord-001835-0s7ok4uw	1998	15	binding	binding	NN
cord-001835-0s7ok4uw	1998	16	with	with	IN
cord-001835-0s7ok4uw	1998	17	P10	P10	NNP
cord-001835-0s7ok4uw	1998	18	.	.	.
cord-001835-0s7ok4uw	1999	1	These	these	DT
cord-001835-0s7ok4uw	1999	2	results	result	NNS
cord-001835-0s7ok4uw	1999	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	1999	4	that	that	IN
cord-001835-0s7ok4uw	1999	5	the	the	DT
cord-001835-0s7ok4uw	1999	6	region	region	NN
cord-001835-0s7ok4uw	1999	7	43	43	CD
cord-001835-0s7ok4uw	1999	8	-	-	SYM
cord-001835-0s7ok4uw	1999	9	72	72	CD
cord-001835-0s7ok4uw	1999	10	from	from	IN
cord-001835-0s7ok4uw	1999	11	the	the	DT
cord-001835-0s7ok4uw	1999	12	C	C	NNP
cord-001835-0s7ok4uw	1999	13	terminus	terminus	NN
cord-001835-0s7ok4uw	1999	14	of	of	IN
cord-001835-0s7ok4uw	1999	15	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	1999	16	is	be	VBZ
cord-001835-0s7ok4uw	1999	17	essential	essential	JJ
cord-001835-0s7ok4uw	1999	18	for	for	IN
cord-001835-0s7ok4uw	1999	19	the	the	DT
cord-001835-0s7ok4uw	1999	20	interaction	interaction	NN
cord-001835-0s7ok4uw	1999	21	with	with	IN
cord-001835-0s7ok4uw	1999	22	P10	P10	NNP
cord-001835-0s7ok4uw	1999	23	.	.	.
cord-001835-0s7ok4uw	2000	1	Further	further	RB
cord-001835-0s7ok4uw	2000	2	,	,	,
cord-001835-0s7ok4uw	2000	3	the	the	DT
cord-001835-0s7ok4uw	2000	4	C	C	NNP
cord-001835-0s7ok4uw	2000	5	del	del	NNP
cord-001835-0s7ok4uw	2000	6	85	85	CD
cord-001835-0s7ok4uw	2000	7	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	2000	8	was	be	VBD
cord-001835-0s7ok4uw	2000	9	inactive	inactive	JJ
cord-001835-0s7ok4uw	2000	10	although	although	IN
cord-001835-0s7ok4uw	2000	11	C	C	NNP
cord-001835-0s7ok4uw	2000	12	del	del	NNP
cord-001835-0s7ok4uw	2000	13	72	72	CD
cord-001835-0s7ok4uw	2000	14	RdRp	rdrp	NN
cord-001835-0s7ok4uw	2000	15	continued	continue	VBD
cord-001835-0s7ok4uw	2000	16	to	to	TO
cord-001835-0s7ok4uw	2000	17	be	be	VB
cord-001835-0s7ok4uw	2000	18	active	active	JJ
cord-001835-0s7ok4uw	2000	19	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2000	20	that	that	IN
cord-001835-0s7ok4uw	2000	21	residues	residue	NNS
cord-001835-0s7ok4uw	2000	22	72	72	CD
cord-001835-0s7ok4uw	2000	23	-	-	SYM
cord-001835-0s7ok4uw	2000	24	85	85	CD
cord-001835-0s7ok4uw	2000	25	from	from	IN
cord-001835-0s7ok4uw	2000	26	the	the	DT
cord-001835-0s7ok4uw	2000	27	C	C	NNP
cord-001835-0s7ok4uw	2000	28	terminus	terminus	NN
cord-001835-0s7ok4uw	2000	29	are	be	VBP
cord-001835-0s7ok4uw	2000	30	crucial	crucial	JJ
cord-001835-0s7ok4uw	2000	31	for	for	IN
cord-001835-0s7ok4uw	2000	32	RdRp	RdRp	NNP
cord-001835-0s7ok4uw	2000	33	activity	activity	NN
cord-001835-0s7ok4uw	2000	34	.	.	.
cord-001835-0s7ok4uw	2001	1	Further	further	JJ
cord-001835-0s7ok4uw	2001	2	studies	study	NNS
cord-001835-0s7ok4uw	2001	3	are	be	VBP
cord-001835-0s7ok4uw	2001	4	in	in	IN
cord-001835-0s7ok4uw	2001	5	progress	progress	NN
cord-001835-0s7ok4uw	2001	6	to	to	TO
cord-001835-0s7ok4uw	2001	7	identify	identify	VB
cord-001835-0s7ok4uw	2001	8	the	the	DT
cord-001835-0s7ok4uw	2001	9	residues	residue	NNS
cord-001835-0s7ok4uw	2001	10	within	within	IN
cord-001835-0s7ok4uw	2001	11	these	these	DT
cord-001835-0s7ok4uw	2001	12	motifs	motif	NNS
cord-001835-0s7ok4uw	2001	13	that	that	WDT
cord-001835-0s7ok4uw	2001	14	may	may	MD
cord-001835-0s7ok4uw	2001	15	be	be	VB
cord-001835-0s7ok4uw	2001	16	essential	essential	JJ
cord-001835-0s7ok4uw	2001	17	for	for	IN
cord-001835-0s7ok4uw	2001	18	the	the	DT
cord-001835-0s7ok4uw	2001	19	activity	activity	NN
cord-001835-0s7ok4uw	2001	20	or	or	CC
cord-001835-0s7ok4uw	2001	21	interaction	interaction	NN
cord-001835-0s7ok4uw	2001	22	with	with	IN
cord-001835-0s7ok4uw	2001	23	P10	P10	NNP
cord-001835-0s7ok4uw	2001	24	.	.	.
cord-001835-0s7ok4uw	2002	1	Aggregation	aggregation	NN
cord-001835-0s7ok4uw	2002	2	of	of	IN
cord-001835-0s7ok4uw	2002	3	androgen	androgen	NN
cord-001835-0s7ok4uw	2002	4	receptor	receptor	NN
cord-001835-0s7ok4uw	2002	5	in	in	IN
cord-001835-0s7ok4uw	2002	6	spinal	spinal	JJ
cord-001835-0s7ok4uw	2002	7	bulbar	bulbar	JJ
cord-001835-0s7ok4uw	2002	8	muscular	muscular	JJ
cord-001835-0s7ok4uw	2002	9	atrophy	atrophy	NN
cord-001835-0s7ok4uw	2002	10	is	be	VBZ
cord-001835-0s7ok4uw	2002	11	a	a	DT
cord-001835-0s7ok4uw	2002	12	multistep	multistep	JJ
cord-001835-0s7ok4uw	2002	13	process	process	NN
cord-001835-0s7ok4uw	2002	14	Spinal	spinal	JJ
cord-001835-0s7ok4uw	2002	15	bulbar	bulbar	NN
cord-001835-0s7ok4uw	2002	16	muscular	muscular	JJ
cord-001835-0s7ok4uw	2002	17	atrophy	atrophy	NN
cord-001835-0s7ok4uw	2002	18	(	(	-LRB-
cord-001835-0s7ok4uw	2002	19	SBMA	SBMA	NNP
cord-001835-0s7ok4uw	2002	20	)	)	-RRB-
cord-001835-0s7ok4uw	2002	21	is	be	VBZ
cord-001835-0s7ok4uw	2002	22	a	a	DT
cord-001835-0s7ok4uw	2002	23	member	member	NN
cord-001835-0s7ok4uw	2002	24	of	of	IN
cord-001835-0s7ok4uw	2002	25	the	the	DT
cord-001835-0s7ok4uw	2002	26	polyglutamine	polyglutamine	NNP
cord-001835-0s7ok4uw	2002	27	(	(	-LRB-
cord-001835-0s7ok4uw	2002	28	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2002	29	)	)	-RRB-
cord-001835-0s7ok4uw	2002	30	expansion	expansion	NN
cord-001835-0s7ok4uw	2002	31	diseases	disease	NNS
cord-001835-0s7ok4uw	2002	32	,	,	,
cord-001835-0s7ok4uw	2002	33	like	like	IN
cord-001835-0s7ok4uw	2002	34	Huntington	Huntington	NNP
cord-001835-0s7ok4uw	2002	35	disease	disease	NN
cord-001835-0s7ok4uw	2002	36	,	,	,
cord-001835-0s7ok4uw	2002	37	and	and	CC
cord-001835-0s7ok4uw	2002	38	it	-PRON-	PRP
cord-001835-0s7ok4uw	2002	39	is	be	VBZ
cord-001835-0s7ok4uw	2002	40	caused	cause	VBN
cord-001835-0s7ok4uw	2002	41	by	by	IN
cord-001835-0s7ok4uw	2002	42	a	a	DT
cord-001835-0s7ok4uw	2002	43	genetic	genetic	JJ
cord-001835-0s7ok4uw	2002	44	expansion	expansion	NN
cord-001835-0s7ok4uw	2002	45	of	of	IN
cord-001835-0s7ok4uw	2002	46	the	the	DT
cord-001835-0s7ok4uw	2002	47	polyCAG	polycag	NN
cord-001835-0s7ok4uw	2002	48	tract	tract	NN
cord-001835-0s7ok4uw	2002	49	in	in	IN
cord-001835-0s7ok4uw	2002	50	exon	exon	NN
cord-001835-0s7ok4uw	2002	51	1	1	CD
cord-001835-0s7ok4uw	2002	52	of	of	IN
cord-001835-0s7ok4uw	2002	53	androgen	androgen	NN
cord-001835-0s7ok4uw	2002	54	receptor	receptor	NN
cord-001835-0s7ok4uw	2002	55	(	(	-LRB-
cord-001835-0s7ok4uw	2002	56	AR	AR	NNP
cord-001835-0s7ok4uw	2002	57	)	)	-RRB-
cord-001835-0s7ok4uw	2003	1	that	that	IN
cord-001835-0s7ok4uw	2003	2	codes	code	NNS
cord-001835-0s7ok4uw	2003	3	for	for	IN
cord-001835-0s7ok4uw	2003	4	the	the	DT
cord-001835-0s7ok4uw	2003	5	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2003	6	region	region	NN
cord-001835-0s7ok4uw	2003	7	.	.	.
cord-001835-0s7ok4uw	2004	1	SBMA	SBMA	NNP
cord-001835-0s7ok4uw	2004	2	is	be	VBZ
cord-001835-0s7ok4uw	2004	3	a	a	DT
cord-001835-0s7ok4uw	2004	4	late	late	JJ
cord-001835-0s7ok4uw	2004	5	onset	onset	NN
cord-001835-0s7ok4uw	2004	6	disease	disease	NN
cord-001835-0s7ok4uw	2004	7	,	,	,
cord-001835-0s7ok4uw	2004	8	which	which	WDT
cord-001835-0s7ok4uw	2004	9	involves	involve	VBZ
cord-001835-0s7ok4uw	2004	10	a	a	DT
cord-001835-0s7ok4uw	2004	11	progressive	progressive	JJ
cord-001835-0s7ok4uw	2004	12	degeneration	degeneration	NN
cord-001835-0s7ok4uw	2004	13	of	of	IN
cord-001835-0s7ok4uw	2004	14	the	the	DT
cord-001835-0s7ok4uw	2004	15	motor	motor	NN
cord-001835-0s7ok4uw	2004	16	neurons	neuron	NNS
cord-001835-0s7ok4uw	2004	17	and	and	CC
cord-001835-0s7ok4uw	2004	18	consequent	consequent	JJ
cord-001835-0s7ok4uw	2004	19	muscular	muscular	JJ
cord-001835-0s7ok4uw	2004	20	atrophy	atrophy	NN
cord-001835-0s7ok4uw	2004	21	.	.	.
cord-001835-0s7ok4uw	2005	1	There	there	EX
cord-001835-0s7ok4uw	2005	2	is	be	VBZ
cord-001835-0s7ok4uw	2005	3	still	still	RB
cord-001835-0s7ok4uw	2005	4	no	no	DT
cord-001835-0s7ok4uw	2005	5	treatment	treatment	NN
cord-001835-0s7ok4uw	2005	6	available	available	JJ
cord-001835-0s7ok4uw	2005	7	for	for	IN
cord-001835-0s7ok4uw	2005	8	this	this	DT
cord-001835-0s7ok4uw	2005	9	disease	disease	NN
cord-001835-0s7ok4uw	2005	10	.	.	.
cord-001835-0s7ok4uw	2006	1	AR	AR	NNP
cord-001835-0s7ok4uw	2006	2	is	be	VBZ
cord-001835-0s7ok4uw	2006	3	a	a	DT
cord-001835-0s7ok4uw	2006	4	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	2006	5	receptor	receptor	NN
cord-001835-0s7ok4uw	2006	6	that	that	WDT
cord-001835-0s7ok4uw	2006	7	responds	respond	VBZ
cord-001835-0s7ok4uw	2006	8	to	to	IN
cord-001835-0s7ok4uw	2006	9	testosterone	testosterone	NN
cord-001835-0s7ok4uw	2006	10	and	and	CC
cord-001835-0s7ok4uw	2006	11	that	that	DT
cord-001835-0s7ok4uw	2006	12	regulates	regulate	VBZ
cord-001835-0s7ok4uw	2006	13	the	the	DT
cord-001835-0s7ok4uw	2006	14	expression	expression	NN
cord-001835-0s7ok4uw	2006	15	of	of	IN
cord-001835-0s7ok4uw	2006	16	the	the	DT
cord-001835-0s7ok4uw	2006	17	masculine	masculine	JJ
cord-001835-0s7ok4uw	2006	18	phenotype	phenotype	NN
cord-001835-0s7ok4uw	2006	19	.	.	.
cord-001835-0s7ok4uw	2007	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2007	2	is	be	VBZ
cord-001835-0s7ok4uw	2007	3	composed	compose	VBN
cord-001835-0s7ok4uw	2007	4	of	of	IN
cord-001835-0s7ok4uw	2007	5	an	an	DT
cord-001835-0s7ok4uw	2007	6	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2007	7	disordered	disordered	JJ
cord-001835-0s7ok4uw	2007	8	Nterminal	Nterminal	NNP
cord-001835-0s7ok4uw	2007	9	domain	domain	NN
cord-001835-0s7ok4uw	2007	10	(	(	-LRB-
cord-001835-0s7ok4uw	2007	11	NTD	NTD	NNP
cord-001835-0s7ok4uw	2007	12	)	)	-RRB-
cord-001835-0s7ok4uw	2007	13	that	that	WDT
cord-001835-0s7ok4uw	2007	14	bears	bear	VBZ
cord-001835-0s7ok4uw	2007	15	the	the	DT
cord-001835-0s7ok4uw	2007	16	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2007	17	tract	tract	NN
cord-001835-0s7ok4uw	2007	18	,	,	,
cord-001835-0s7ok4uw	2007	19	a	a	DT
cord-001835-0s7ok4uw	2007	20	DNA	dna	NN
cord-001835-0s7ok4uw	2007	21	binding	binding	NN
cord-001835-0s7ok4uw	2007	22	domain	domain	NN
cord-001835-0s7ok4uw	2007	23	and	and	CC
cord-001835-0s7ok4uw	2007	24	a	a	DT
cord-001835-0s7ok4uw	2007	25	ligand	ligand	NN
cord-001835-0s7ok4uw	2007	26	binding	bind	VBG
cord-001835-0s7ok4uw	2007	27	domain	domain	NN
cord-001835-0s7ok4uw	2007	28	.	.	.
cord-001835-0s7ok4uw	2008	1	Aggregates	Aggregates	NNPS
cord-001835-0s7ok4uw	2008	2	of	of	IN
cord-001835-0s7ok4uw	2008	3	AR	AR	NNP
cord-001835-0s7ok4uw	2008	4	protein	protein	NN
cord-001835-0s7ok4uw	2008	5	with	with	IN
cord-001835-0s7ok4uw	2008	6	an	an	DT
cord-001835-0s7ok4uw	2008	7	extended	extended	JJ
cord-001835-0s7ok4uw	2008	8	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2008	9	are	be	VBP
cord-001835-0s7ok4uw	2008	10	observed	observe	VBN
cord-001835-0s7ok4uw	2008	11	in	in	IN
cord-001835-0s7ok4uw	2008	12	the	the	DT
cord-001835-0s7ok4uw	2008	13	motor	motor	NN
cord-001835-0s7ok4uw	2008	14	neurons	neuron	NNS
cord-001835-0s7ok4uw	2008	15	of	of	IN
cord-001835-0s7ok4uw	2008	16	SBMA	SBMA	NNP
cord-001835-0s7ok4uw	2008	17	patients	patient	NNS
cord-001835-0s7ok4uw	2008	18	.	.	.
cord-001835-0s7ok4uw	2009	1	In	in	IN
cord-001835-0s7ok4uw	2009	2	vitro	vitro	FW
cord-001835-0s7ok4uw	2009	3	studies	study	NNS
cord-001835-0s7ok4uw	2009	4	showed	show	VBD
cord-001835-0s7ok4uw	2009	5	that	that	IN
cord-001835-0s7ok4uw	2009	6	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2009	7	of	of	IN
cord-001835-0s7ok4uw	2009	8	Androgen	Androgen	NNP
cord-001835-0s7ok4uw	2009	9	Receptor	Receptor	NNP
cord-001835-0s7ok4uw	2009	10	takes	take	VBZ
cord-001835-0s7ok4uw	2009	11	place	place	NN
cord-001835-0s7ok4uw	2009	12	only	only	RB
cord-001835-0s7ok4uw	2009	13	in	in	IN
cord-001835-0s7ok4uw	2009	14	presence	presence	NN
cord-001835-0s7ok4uw	2009	15	of	of	IN
cord-001835-0s7ok4uw	2009	16	testosterone1	testosterone1	NN
cord-001835-0s7ok4uw	2009	17	and	and	CC
cord-001835-0s7ok4uw	2009	18	that	that	IN
cord-001835-0s7ok4uw	2009	19	the	the	DT
cord-001835-0s7ok4uw	2009	20	cleavage	cleavage	NN
cord-001835-0s7ok4uw	2009	21	of	of	IN
cord-001835-0s7ok4uw	2009	22	the	the	DT
cord-001835-0s7ok4uw	2009	23	protein	protein	NN
cord-001835-0s7ok4uw	2009	24	by	by	IN
cord-001835-0s7ok4uw	2009	25	caspase	caspase	NN
cord-001835-0s7ok4uw	2009	26	3	3	CD
cord-001835-0s7ok4uw	2009	27	is	be	VBZ
cord-001835-0s7ok4uw	2009	28	a	a	DT
cord-001835-0s7ok4uw	2009	29	crucial	crucial	JJ
cord-001835-0s7ok4uw	2009	30	event	event	NN
cord-001835-0s7ok4uw	2009	31	for	for	IN
cord-001835-0s7ok4uw	2009	32	cytotoxicity	cytotoxicity	NN
cord-001835-0s7ok4uw	2009	33	.	.	.
cord-001835-0s7ok4uw	2010	1	However	however	RB
cord-001835-0s7ok4uw	2010	2	,	,	,
cord-001835-0s7ok4uw	2010	3	there	there	EX
cord-001835-0s7ok4uw	2010	4	is	be	VBZ
cord-001835-0s7ok4uw	2010	5	no	no	DT
cord-001835-0s7ok4uw	2010	6	clear	clear	JJ
cord-001835-0s7ok4uw	2010	7	knowledge	knowledge	NN
cord-001835-0s7ok4uw	2010	8	of	of	IN
cord-001835-0s7ok4uw	2010	9	the	the	DT
cord-001835-0s7ok4uw	2010	10	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2010	11	of	of	IN
cord-001835-0s7ok4uw	2010	12	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2010	13	,	,	,
cord-001835-0s7ok4uw	2010	14	for	for	IN
cord-001835-0s7ok4uw	2010	15	this	this	DT
cord-001835-0s7ok4uw	2010	16	protein	protein	NN
cord-001835-0s7ok4uw	2010	17	.	.	.
cord-001835-0s7ok4uw	2011	1	An	an	DT
cord-001835-0s7ok4uw	2011	2	increasing	increase	VBG
cord-001835-0s7ok4uw	2011	3	body	body	NN
cord-001835-0s7ok4uw	2011	4	of	of	IN
cord-001835-0s7ok4uw	2011	5	evidence	evidence	NN
cord-001835-0s7ok4uw	2011	6	supports	support	VBZ
cord-001835-0s7ok4uw	2011	7	the	the	DT
cord-001835-0s7ok4uw	2011	8	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	2011	9	that	that	IN
cord-001835-0s7ok4uw	2011	10	the	the	DT
cord-001835-0s7ok4uw	2011	11	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2011	12	of	of	IN
cord-001835-0s7ok4uw	2011	13	these	these	DT
cord-001835-0s7ok4uw	2011	14	proteins	protein	NNS
cord-001835-0s7ok4uw	2011	15	is	be	VBZ
cord-001835-0s7ok4uw	2011	16	controlled	control	VBN
cord-001835-0s7ok4uw	2011	17	by	by	IN
cord-001835-0s7ok4uw	2011	18	regions	region	NNS
cord-001835-0s7ok4uw	2011	19	flanking	flank	VBG
cord-001835-0s7ok4uw	2011	20	the	the	DT
cord-001835-0s7ok4uw	2011	21	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2011	22	tract	tract	NN
cord-001835-0s7ok4uw	2011	23	,	,	,
cord-001835-0s7ok4uw	2011	24	by	by	IN
cord-001835-0s7ok4uw	2011	25	regulating	regulate	VBG
cord-001835-0s7ok4uw	2011	26	the	the	DT
cord-001835-0s7ok4uw	2011	27	rate	rate	NN
cord-001835-0s7ok4uw	2011	28	of	of	IN
cord-001835-0s7ok4uw	2011	29	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2011	30	depending	depend	VBG
cord-001835-0s7ok4uw	2011	31	on	on	IN
cord-001835-0s7ok4uw	2011	32	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2011	33	secondary	secondary	JJ
cord-001835-0s7ok4uw	2011	34	structure	structure	NN
cord-001835-0s7ok4uw	2011	35	.	.	.
cord-001835-0s7ok4uw	2012	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2012	2	have	have	VBP
cord-001835-0s7ok4uw	2012	3	applied	apply	VBN
cord-001835-0s7ok4uw	2012	4	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	2012	5	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	2012	6	resonance	resonance	NN
cord-001835-0s7ok4uw	2012	7	(	(	-LRB-
cord-001835-0s7ok4uw	2012	8	NMR	NMR	NNP
cord-001835-0s7ok4uw	2012	9	)	)	-RRB-
cord-001835-0s7ok4uw	2012	10	and	and	CC
cord-001835-0s7ok4uw	2012	11	circular	circular	JJ
cord-001835-0s7ok4uw	2012	12	dichroism	dichroism	NN
cord-001835-0s7ok4uw	2012	13	for	for	IN
cord-001835-0s7ok4uw	2012	14	generating	generate	VBG
cord-001835-0s7ok4uw	2012	15	information	information	NN
cord-001835-0s7ok4uw	2012	16	on	on	IN
cord-001835-0s7ok4uw	2012	17	the	the	DT
cord-001835-0s7ok4uw	2012	18	secondary	secondary	JJ
cord-001835-0s7ok4uw	2012	19	structure	structure	NN
cord-001835-0s7ok4uw	2012	20	of	of	IN
cord-001835-0s7ok4uw	2012	21	the	the	DT
cord-001835-0s7ok4uw	2012	22	N	n	CD
cord-001835-0s7ok4uw	2012	23	-	-	HYPH
cord-001835-0s7ok4uw	2012	24	terminal	terminal	NN
cord-001835-0s7ok4uw	2012	25	cleavage	cleavage	NN
cord-001835-0s7ok4uw	2012	26	product	product	NN
cord-001835-0s7ok4uw	2012	27	of	of	IN
cord-001835-0s7ok4uw	2012	28	AR	AR	NNP
cord-001835-0s7ok4uw	2012	29	by	by	IN
cord-001835-0s7ok4uw	2012	30	caspase	caspase	NN
cord-001835-0s7ok4uw	2012	31	3	3	CD
cord-001835-0s7ok4uw	2013	1	and	and	CC
cord-001835-0s7ok4uw	2013	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2013	3	have	have	VBP
cord-001835-0s7ok4uw	2013	4	studied	study	VBN
cord-001835-0s7ok4uw	2013	5	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2013	6	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2013	7	with	with	IN
cord-001835-0s7ok4uw	2013	8	a	a	DT
cord-001835-0s7ok4uw	2013	9	set	set	NN
cord-001835-0s7ok4uw	2013	10	of	of	IN
cord-001835-0s7ok4uw	2013	11	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	2013	12	methods	method	NNS
cord-001835-0s7ok4uw	2013	13	,	,	,
cord-001835-0s7ok4uw	2013	14	like	like	IN
cord-001835-0s7ok4uw	2013	15	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2013	16	light	light	JJ
cord-001835-0s7ok4uw	2013	17	scattering	scattering	NN
cord-001835-0s7ok4uw	2013	18	,	,	,
cord-001835-0s7ok4uw	2013	19	an	an	DT
cord-001835-0s7ok4uw	2013	20	HPLC	HPLC	NNP
cord-001835-0s7ok4uw	2013	21	sedimentation	sedimentation	NN
cord-001835-0s7ok4uw	2013	22	assay	assay	NN
cord-001835-0s7ok4uw	2013	23	and	and	CC
cord-001835-0s7ok4uw	2013	24	transmission	transmission	NN
cord-001835-0s7ok4uw	2013	25	electron	electron	NN
cord-001835-0s7ok4uw	2013	26	microscopy	microscopy	NN
cord-001835-0s7ok4uw	2013	27	.	.	.
cord-001835-0s7ok4uw	2014	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2014	2	have	have	VBP
cord-001835-0s7ok4uw	2014	3	found	find	VBN
cord-001835-0s7ok4uw	2014	4	that	that	IN
cord-001835-0s7ok4uw	2014	5	the	the	DT
cord-001835-0s7ok4uw	2014	6	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2014	7	tract	tract	NN
cord-001835-0s7ok4uw	2014	8	of	of	IN
cord-001835-0s7ok4uw	2014	9	AR	AR	NNP
cord-001835-0s7ok4uw	2014	10	presents	present	VBZ
cord-001835-0s7ok4uw	2014	11	a	a	DT
cord-001835-0s7ok4uw	2014	12	high	high	JJ
cord-001835-0s7ok4uw	2014	13	degree	degree	NN
cord-001835-0s7ok4uw	2014	14	of	of	IN
cord-001835-0s7ok4uw	2014	15	helicity	helicity	NN
cord-001835-0s7ok4uw	2014	16	.	.	.
cord-001835-0s7ok4uw	2015	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2015	2	attribute	attribute	VBP
cord-001835-0s7ok4uw	2015	3	this	this	DT
cord-001835-0s7ok4uw	2015	4	conformation	conformation	NN
cord-001835-0s7ok4uw	2015	5	to	to	IN
cord-001835-0s7ok4uw	2015	6	the	the	DT
cord-001835-0s7ok4uw	2015	7	N	n	CD
cord-001835-0s7ok4uw	2015	8	-	-	HYPH
cord-001835-0s7ok4uw	2015	9	terminal	terminal	JJ
cord-001835-0s7ok4uw	2015	10	flanking	flank	VBG
cord-001835-0s7ok4uw	2015	11	region	region	NN
cord-001835-0s7ok4uw	2015	12	,	,	,
cord-001835-0s7ok4uw	2015	13	characterized	characterize	VBN
cord-001835-0s7ok4uw	2015	14	by	by	IN
cord-001835-0s7ok4uw	2015	15	high	high	JJ
cord-001835-0s7ok4uw	2015	16	helicity	helicity	NN
cord-001835-0s7ok4uw	2015	17	and	and	CC
cord-001835-0s7ok4uw	2015	18	we	-PRON-	PRP
cord-001835-0s7ok4uw	2015	19	have	have	VBP
cord-001835-0s7ok4uw	2015	20	tested	test	VBN
cord-001835-0s7ok4uw	2015	21	this	this	DT
cord-001835-0s7ok4uw	2015	22	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	2015	23	by	by	IN
cord-001835-0s7ok4uw	2015	24	performing	perform	VBG
cord-001835-0s7ok4uw	2015	25	mutations	mutation	NNS
cord-001835-0s7ok4uw	2015	26	.	.	.
cord-001835-0s7ok4uw	2016	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2016	2	have	have	VBP
cord-001835-0s7ok4uw	2016	3	also	also	RB
cord-001835-0s7ok4uw	2016	4	observed	observe	VBN
cord-001835-0s7ok4uw	2016	5	that	that	IN
cord-001835-0s7ok4uw	2016	6	the	the	DT
cord-001835-0s7ok4uw	2016	7	rate	rate	NN
cord-001835-0s7ok4uw	2016	8	of	of	IN
cord-001835-0s7ok4uw	2016	9	the	the	DT
cord-001835-0s7ok4uw	2016	10	first	first	JJ
cord-001835-0s7ok4uw	2016	11	step	step	NN
cord-001835-0s7ok4uw	2016	12	of	of	IN
cord-001835-0s7ok4uw	2016	13	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	2016	14	is	be	VBZ
cord-001835-0s7ok4uw	2016	15	not	not	RB
cord-001835-0s7ok4uw	2016	16	dependent	dependent	JJ
cord-001835-0s7ok4uw	2016	17	on	on	IN
cord-001835-0s7ok4uw	2016	18	the	the	DT
cord-001835-0s7ok4uw	2016	19	number	number	NN
cord-001835-0s7ok4uw	2016	20	of	of	IN
cord-001835-0s7ok4uw	2016	21	glutamine	glutamine	NN
cord-001835-0s7ok4uw	2016	22	repeats	repeat	NNS
cord-001835-0s7ok4uw	2016	23	,	,	,
cord-001835-0s7ok4uw	2016	24	but	but	CC
cord-001835-0s7ok4uw	2016	25	instead	instead	RB
cord-001835-0s7ok4uw	2016	26	is	be	VBZ
cord-001835-0s7ok4uw	2016	27	due	due	JJ
cord-001835-0s7ok4uw	2016	28	to	to	IN
cord-001835-0s7ok4uw	2016	29	self	self	NN
cord-001835-0s7ok4uw	2016	30	interactions	interaction	NNS
cord-001835-0s7ok4uw	2016	31	of	of	IN
cord-001835-0s7ok4uw	2016	32	a	a	DT
cord-001835-0s7ok4uw	2016	33	region	region	NN
cord-001835-0s7ok4uw	2016	34	N	n	CD
cord-001835-0s7ok4uw	2016	35	-	-	HYPH
cord-001835-0s7ok4uw	2016	36	terminal	terminal	NN
cord-001835-0s7ok4uw	2016	37	to	to	IN
cord-001835-0s7ok4uw	2016	38	and	and	CC
cord-001835-0s7ok4uw	2016	39	far	far	RB
cord-001835-0s7ok4uw	2016	40	from	from	IN
cord-001835-0s7ok4uw	2016	41	the	the	DT
cord-001835-0s7ok4uw	2016	42	polyQ.	polyq.	NN
cord-001835-0s7ok4uw	2017	1	Its	-PRON-	PRP$
cord-001835-0s7ok4uw	2017	2	progression	progression	NN
cord-001835-0s7ok4uw	2017	3	to	to	IN
cord-001835-0s7ok4uw	2017	4	fibril	fibril	NNP
cord-001835-0s7ok4uw	2017	5	is	be	VBZ
cord-001835-0s7ok4uw	2017	6	dependent	dependent	JJ
cord-001835-0s7ok4uw	2017	7	to	to	IN
cord-001835-0s7ok4uw	2017	8	the	the	DT
cord-001835-0s7ok4uw	2017	9	number	number	NN
cord-001835-0s7ok4uw	2017	10	of	of	IN
cord-001835-0s7ok4uw	2017	11	glutamines	glutamine	NNS
cord-001835-0s7ok4uw	2017	12	in	in	IN
cord-001835-0s7ok4uw	2017	13	the	the	DT
cord-001835-0s7ok4uw	2017	14	tract	tract	NN
cord-001835-0s7ok4uw	2017	15	.	.	.
cord-001835-0s7ok4uw	2018	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2018	2	have	have	VBP
cord-001835-0s7ok4uw	2018	3	therefore	therefore	RB
cord-001835-0s7ok4uw	2018	4	identified	identify	VBN
cord-001835-0s7ok4uw	2018	5	two	two	CD
cord-001835-0s7ok4uw	2018	6	steps	step	NNS
cord-001835-0s7ok4uw	2018	7	in	in	IN
cord-001835-0s7ok4uw	2018	8	the	the	DT
cord-001835-0s7ok4uw	2018	9	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2018	10	process	process	NN
cord-001835-0s7ok4uw	2018	11	of	of	IN
cord-001835-0s7ok4uw	2018	12	AR	AR	NNP
cord-001835-0s7ok4uw	2018	13	,	,	,
cord-001835-0s7ok4uw	2018	14	where	where	WRB
cord-001835-0s7ok4uw	2018	15	a	a	DT
cord-001835-0s7ok4uw	2018	16	motif	motif	NN
cord-001835-0s7ok4uw	2018	17	far	far	RB
cord-001835-0s7ok4uw	2018	18	from	from	IN
cord-001835-0s7ok4uw	2018	19	the	the	DT
cord-001835-0s7ok4uw	2018	20	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2018	21	at	at	IN
cord-001835-0s7ok4uw	2018	22	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2018	23	N	n	CD
cord-001835-0s7ok4uw	2018	24	-	-	HYPH
cord-001835-0s7ok4uw	2018	25	terminal	terminal	NN
cord-001835-0s7ok4uw	2018	26	drives	drive	NNS
cord-001835-0s7ok4uw	2018	27	the	the	DT
cord-001835-0s7ok4uw	2018	28	early	early	JJ
cord-001835-0s7ok4uw	2018	29	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	2018	30	,	,	,
cord-001835-0s7ok4uw	2018	31	followed	follow	VBN
cord-001835-0s7ok4uw	2018	32	by	by	IN
cord-001835-0s7ok4uw	2018	33	the	the	DT
cord-001835-0s7ok4uw	2018	34	interaction	interaction	NN
cord-001835-0s7ok4uw	2018	35	of	of	IN
cord-001835-0s7ok4uw	2018	36	the	the	DT
cord-001835-0s7ok4uw	2018	37	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2018	38	chains	chain	NNS
cord-001835-0s7ok4uw	2018	39	that	that	WDT
cord-001835-0s7ok4uw	2018	40	stabilize	stabilize	VBP
cord-001835-0s7ok4uw	2018	41	it	-PRON-	PRP
cord-001835-0s7ok4uw	2018	42	and	and	CC
cord-001835-0s7ok4uw	2018	43	determine	determine	VB
cord-001835-0s7ok4uw	2018	44	the	the	DT
cord-001835-0s7ok4uw	2018	45	progression	progression	NN
cord-001835-0s7ok4uw	2018	46	to	to	IN
cord-001835-0s7ok4uw	2018	47	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2018	48	.	.	.
cord-001835-0s7ok4uw	2019	1	These	these	DT
cord-001835-0s7ok4uw	2019	2	findings	finding	NNS
cord-001835-0s7ok4uw	2019	3	shed	shed	VBD
cord-001835-0s7ok4uw	2019	4	a	a	DT
cord-001835-0s7ok4uw	2019	5	light	light	NN
cord-001835-0s7ok4uw	2019	6	for	for	IN
cord-001835-0s7ok4uw	2019	7	possible	possible	JJ
cord-001835-0s7ok4uw	2019	8	interventions	intervention	NNS
cord-001835-0s7ok4uw	2019	9	on	on	IN
cord-001835-0s7ok4uw	2019	10	the	the	DT
cord-001835-0s7ok4uw	2019	11	AR	AR	NNP
cord-001835-0s7ok4uw	2019	12	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	2019	13	process	process	NN
cord-001835-0s7ok4uw	2019	14	,	,	,
cord-001835-0s7ok4uw	2019	15	thus	thus	RB
cord-001835-0s7ok4uw	2019	16	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2019	17	a	a	DT
cord-001835-0s7ok4uw	2019	18	different	different	JJ
cord-001835-0s7ok4uw	2019	19	strategy	strategy	NN
cord-001835-0s7ok4uw	2019	20	to	to	TO
cord-001835-0s7ok4uw	2019	21	study	study	VB
cord-001835-0s7ok4uw	2019	22	the	the	DT
cord-001835-0s7ok4uw	2019	23	onset	onset	NN
cord-001835-0s7ok4uw	2019	24	of	of	IN
cord-001835-0s7ok4uw	2019	25	the	the	DT
cord-001835-0s7ok4uw	2019	26	disease	disease	NN
cord-001835-0s7ok4uw	2019	27	in	in	IN
cord-001835-0s7ok4uw	2019	28	SBMA	SBMA	NNP
cord-001835-0s7ok4uw	2019	29	patients	patient	NNS
cord-001835-0s7ok4uw	2019	30	.	.	.
cord-001835-0s7ok4uw	2020	1	Destabilizing	destabilize	VBG
cord-001835-0s7ok4uw	2020	2	the	the	DT
cord-001835-0s7ok4uw	2020	3	Transient	Transient	NNP
cord-001835-0s7ok4uw	2020	4	Helical	Helical	NNP
cord-001835-0s7ok4uw	2020	5	Conformation	Conformation	NNP
cord-001835-0s7ok4uw	2020	6	of	of	IN
cord-001835-0s7ok4uw	2020	7	Islet	Islet	NNP
cord-001835-0s7ok4uw	2020	8	Amyloid	Amyloid	NNP
cord-001835-0s7ok4uw	2020	9	Polypeptide	Polypeptide	NNP
cord-001835-0s7ok4uw	2020	10	Hastens	hasten	VBZ
cord-001835-0s7ok4uw	2020	11	Peptide	Peptide	NNP
cord-001835-0s7ok4uw	2020	12	Self	Self	NNP
cord-001835-0s7ok4uw	2020	13	-	-	HYPH
cord-001835-0s7ok4uw	2020	14	Assembly	Assembly	NNP
cord-001835-0s7ok4uw	2020	15	and	and	CC
cord-001835-0s7ok4uw	2020	16	Potentiates	Potentiates	NNP
cord-001835-0s7ok4uw	2020	17	Cytotoxicity	Cytotoxicity	NNP
cord-001835-0s7ok4uw	2020	18	Carole	Carole	NNP
cord-001835-0s7ok4uw	2020	19	Anne	Anne	NNP
cord-001835-0s7ok4uw	2020	20	de	de	NNP
cord-001835-0s7ok4uw	2020	21	Carufel	Carufel	NNP
cord-001835-0s7ok4uw	2020	22	1	1	CD
cord-001835-0s7ok4uw	2020	23	,	,	,
cord-001835-0s7ok4uw	2020	24	Phuong	Phuong	NNP
cord-001835-0s7ok4uw	2020	25	Trang	Trang	NNP
cord-001835-0s7ok4uw	2020	26	Nguyen	Nguyen	NNP
cord-001835-0s7ok4uw	2020	27	1	1	CD
cord-001835-0s7ok4uw	2020	28	,	,	,
cord-001835-0s7ok4uw	2020	29	Alexandre	Alexandre	NNP
cord-001835-0s7ok4uw	2020	30	Arnold	Arnold	NNP
cord-001835-0s7ok4uw	2020	31	1	1	CD
cord-001835-0s7ok4uw	2020	32	,	,	,
cord-001835-0s7ok4uw	2020	33	Isabelle	Isabelle	NNP
cord-001835-0s7ok4uw	2020	34	Marcotte	Marcotte	NNP
cord-001835-0s7ok4uw	2020	35	1	1	CD
cord-001835-0s7ok4uw	2020	36	,	,	,
cord-001835-0s7ok4uw	2020	37	Steve	Steve	NNP
cord-001835-0s7ok4uw	2020	38	Bourgault	Bourgault	NNP
cord-001835-0s7ok4uw	2020	39	1	1	CD
cord-001835-0s7ok4uw	2020	40	1	1	CD
cord-001835-0s7ok4uw	2020	41	Amyloidogenic	Amyloidogenic	NNP
cord-001835-0s7ok4uw	2020	42	polypeptides	polypeptide	NNS
cord-001835-0s7ok4uw	2020	43	can	can	MD
cord-001835-0s7ok4uw	2020	44	be	be	VB
cord-001835-0s7ok4uw	2020	45	divided	divide	VBN
cord-001835-0s7ok4uw	2020	46	into	into	IN
cord-001835-0s7ok4uw	2020	47	two	two	CD
cord-001835-0s7ok4uw	2020	48	different	different	JJ
cord-001835-0s7ok4uw	2020	49	structural	structural	JJ
cord-001835-0s7ok4uw	2020	50	classes	class	NNS
cord-001835-0s7ok4uw	2020	51	:	:	:
cord-001835-0s7ok4uw	2020	52	those	those	DT
cord-001835-0s7ok4uw	2020	53	that	that	WDT
cord-001835-0s7ok4uw	2020	54	are	be	VBP
cord-001835-0s7ok4uw	2020	55	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2020	56	disordered	disordered	JJ
cord-001835-0s7ok4uw	2020	57	and	and	CC
cord-001835-0s7ok4uw	2020	58	those	those	DT
cord-001835-0s7ok4uw	2020	59	that	that	WDT
cord-001835-0s7ok4uw	2020	60	show	show	VBP
cord-001835-0s7ok4uw	2020	61	a	a	DT
cord-001835-0s7ok4uw	2020	62	well	well	RB
cord-001835-0s7ok4uw	2020	63	-	-	HYPH
cord-001835-0s7ok4uw	2020	64	defined	define	VBN
cord-001835-0s7ok4uw	2020	65	structure	structure	NN
cord-001835-0s7ok4uw	2020	66	in	in	IN
cord-001835-0s7ok4uw	2020	67	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2020	68	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	2020	69	soluble	soluble	JJ
cord-001835-0s7ok4uw	2020	70	state	state	NN
cord-001835-0s7ok4uw	2020	71	.	.	.
cord-001835-0s7ok4uw	2021	1	Natively	natively	RB
cord-001835-0s7ok4uw	2021	2	folded	fold	VBN
cord-001835-0s7ok4uw	2021	3	proteins	protein	NNS
cord-001835-0s7ok4uw	2021	4	,	,	,
cord-001835-0s7ok4uw	2021	5	such	such	JJ
cord-001835-0s7ok4uw	2021	6	as	as	IN
cord-001835-0s7ok4uw	2021	7	transthyretin	transthyretin	NNP
cord-001835-0s7ok4uw	2021	8	,	,	,
cord-001835-0s7ok4uw	2021	9	have	have	VBP
cord-001835-0s7ok4uw	2021	10	to	to	TO
cord-001835-0s7ok4uw	2021	11	unfold	unfold	VB
cord-001835-0s7ok4uw	2021	12	(	(	-LRB-
cord-001835-0s7ok4uw	2021	13	or	or	CC
cord-001835-0s7ok4uw	2021	14	misfold	misfold	VB
cord-001835-0s7ok4uw	2021	15	)	)	-RRB-
cord-001835-0s7ok4uw	2021	16	,	,	,
cord-001835-0s7ok4uw	2021	17	at	at	IN
cord-001835-0s7ok4uw	2021	18	least	least	JJS
cord-001835-0s7ok4uw	2021	19	partially	partially	RB
cord-001835-0s7ok4uw	2021	20	,	,	,
cord-001835-0s7ok4uw	2021	21	to	to	TO
cord-001835-0s7ok4uw	2021	22	form	form	VB
cord-001835-0s7ok4uw	2021	23	amyloids	amyloid	NNS
cord-001835-0s7ok4uw	2021	24	.	.	.
cord-001835-0s7ok4uw	2022	1	In	in	IN
cord-001835-0s7ok4uw	2022	2	contrast	contrast	NN
cord-001835-0s7ok4uw	2022	3	,	,	,
cord-001835-0s7ok4uw	2022	4	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2022	5	disordered	disordered	JJ
cord-001835-0s7ok4uw	2022	6	polypeptides	polypeptide	NNS
cord-001835-0s7ok4uw	2022	7	,	,	,
cord-001835-0s7ok4uw	2022	8	such	such	JJ
cord-001835-0s7ok4uw	2022	9	as	as	IN
cord-001835-0s7ok4uw	2022	10	the	the	DT
cord-001835-0s7ok4uw	2022	11	islet	islet	NN
cord-001835-0s7ok4uw	2022	12	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2022	13	polypeptides	polypeptide	NNS
cord-001835-0s7ok4uw	2022	14	(	(	-LRB-
cord-001835-0s7ok4uw	2022	15	IAPP	IAPP	NNP
cord-001835-0s7ok4uw	2022	16	)	)	-RRB-
cord-001835-0s7ok4uw	2022	17	and	and	CC
cord-001835-0s7ok4uw	2022	18	Abeta	Abeta	NNP
cord-001835-0s7ok4uw	2022	19	peptide	peptide	NN
cord-001835-0s7ok4uw	2022	20	,	,	,
cord-001835-0s7ok4uw	2022	21	need	need	VBP
cord-001835-0s7ok4uw	2022	22	to	to	TO
cord-001835-0s7ok4uw	2022	23	undergo	undergo	VB
cord-001835-0s7ok4uw	2022	24	conformational	conformational	JJ
cord-001835-0s7ok4uw	2022	25	rearrangements	rearrangement	NNS
cord-001835-0s7ok4uw	2022	26	allowing	allow	VBG
cord-001835-0s7ok4uw	2022	27	the	the	DT
cord-001835-0s7ok4uw	2022	28	formation	formation	NN
cord-001835-0s7ok4uw	2022	29	of	of	IN
cord-001835-0s7ok4uw	2022	30	locally	locally	RB
cord-001835-0s7ok4uw	2022	31	ordered	order	VBN
cord-001835-0s7ok4uw	2022	32	structure(s	structure(s	NN
cord-001835-0s7ok4uw	2022	33	)	)	-RRB-
cord-001835-0s7ok4uw	2022	34	to	to	TO
cord-001835-0s7ok4uw	2022	35	initiate	initiate	VB
cord-001835-0s7ok4uw	2022	36	the	the	DT
cord-001835-0s7ok4uw	2022	37	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	2022	38	process	process	NN
cord-001835-0s7ok4uw	2022	39	.	.	.
cord-001835-0s7ok4uw	2023	1	Studies	study	NNS
cord-001835-0s7ok4uw	2023	2	have	have	VBP
cord-001835-0s7ok4uw	2023	3	shown	show	VBN
cord-001835-0s7ok4uw	2023	4	that	that	IN
cord-001835-0s7ok4uw	2023	5	IAPP	IAPP	NNP
cord-001835-0s7ok4uw	2023	6	and	and	CC
cord-001835-0s7ok4uw	2023	7	Abeta	Abeta	NNP
cord-001835-0s7ok4uw	2023	8	adopt	adopt	VB
cord-001835-0s7ok4uw	2023	9	an	an	DT
cord-001835-0s7ok4uw	2023	10	alphahelix	alphahelix	JJ
cord-001835-0s7ok4uw	2023	11	conformation	conformation	NN
cord-001835-0s7ok4uw	2023	12	in	in	IN
cord-001835-0s7ok4uw	2023	13	the	the	DT
cord-001835-0s7ok4uw	2023	14	initial	initial	JJ
cord-001835-0s7ok4uw	2023	15	steps	step	NNS
cord-001835-0s7ok4uw	2023	16	of	of	IN
cord-001835-0s7ok4uw	2023	17	amyloidogenesis	amyloidogenesis	NNP
cord-001835-0s7ok4uw	2023	18	.	.	.
cord-001835-0s7ok4uw	2024	1	This	this	DT
cord-001835-0s7ok4uw	2024	2	intermediate	intermediate	NN
cord-001835-0s7ok4uw	2024	3	is	be	VBZ
cord-001835-0s7ok4uw	2024	4	believed	believe	VBN
cord-001835-0s7ok4uw	2024	5	to	to	TO
cord-001835-0s7ok4uw	2024	6	be	be	VB
cord-001835-0s7ok4uw	2024	7	on	on	IN
cord-001835-0s7ok4uw	2024	8	-	-	HYPH
cord-001835-0s7ok4uw	2024	9	pathway	pathway	NN
cord-001835-0s7ok4uw	2024	10	to	to	IN
cord-001835-0s7ok4uw	2024	11	fibril	fibril	NNP
cord-001835-0s7ok4uw	2024	12	formation	formation	NN
cord-001835-0s7ok4uw	2024	13	,	,	,
cord-001835-0s7ok4uw	2024	14	although	although	IN
cord-001835-0s7ok4uw	2024	15	this	this	DT
cord-001835-0s7ok4uw	2024	16	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	2024	17	is	be	VBZ
cord-001835-0s7ok4uw	2024	18	still	still	RB
cord-001835-0s7ok4uw	2024	19	the	the	DT
cord-001835-0s7ok4uw	2024	20	matter	matter	NN
cord-001835-0s7ok4uw	2024	21	of	of	IN
cord-001835-0s7ok4uw	2024	22	debate	debate	NN
cord-001835-0s7ok4uw	2024	23	.	.	.
cord-001835-0s7ok4uw	2025	1	In	in	IN
cord-001835-0s7ok4uw	2025	2	this	this	DT
cord-001835-0s7ok4uw	2025	3	study	study	NN
cord-001835-0s7ok4uw	2025	4	,	,	,
cord-001835-0s7ok4uw	2025	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2025	6	designed	design	VBD
cord-001835-0s7ok4uw	2025	7	human	human	JJ
cord-001835-0s7ok4uw	2025	8	IAPP	IAPP	NNP
cord-001835-0s7ok4uw	2025	9	(	(	-LRB-
cord-001835-0s7ok4uw	2025	10	hIAPP	hIAPP	NNP
cord-001835-0s7ok4uw	2025	11	)	)	-RRB-
cord-001835-0s7ok4uw	2025	12	derivatives	derivative	NNS
cord-001835-0s7ok4uw	2025	13	in	in	IN
cord-001835-0s7ok4uw	2025	14	which	which	WDT
cord-001835-0s7ok4uw	2025	15	alpha	alpha	NN
cord-001835-0s7ok4uw	2025	16	-	-	HYPH
cord-001835-0s7ok4uw	2025	17	helix	helix	NN
cord-001835-0s7ok4uw	2025	18	destabilizing	destabilizing	JJ
cord-001835-0s7ok4uw	2025	19	substitutions	substitution	NNS
cord-001835-0s7ok4uw	2025	20	were	be	VBD
cord-001835-0s7ok4uw	2025	21	incorporated	incorporate	VBN
cord-001835-0s7ok4uw	2025	22	into	into	IN
cord-001835-0s7ok4uw	2025	23	the	the	DT
cord-001835-0s7ok4uw	2025	24	putative	putative	JJ
cord-001835-0s7ok4uw	2025	25	helical	helical	JJ
cord-001835-0s7ok4uw	2025	26	segment	segment	NN
cord-001835-0s7ok4uw	2025	27	of	of	IN
cord-001835-0s7ok4uw	2025	28	IAPP	IAPP	NNP
cord-001835-0s7ok4uw	2025	29	to	to	TO
cord-001835-0s7ok4uw	2025	30	probe	probe	VB
cord-001835-0s7ok4uw	2025	31	the	the	DT
cord-001835-0s7ok4uw	2025	32	initial	initial	JJ
cord-001835-0s7ok4uw	2025	33	structural	structural	JJ
cord-001835-0s7ok4uw	2025	34	event	event	NN
cord-001835-0s7ok4uw	2025	35	in	in	IN
cord-001835-0s7ok4uw	2025	36	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2025	37	formation	formation	NN
cord-001835-0s7ok4uw	2025	38	.	.	.
cord-001835-0s7ok4uw	2026	1	Using	use	VBG
cord-001835-0s7ok4uw	2026	2	trifluoroethanol	trifluoroethanol	JJ
cord-001835-0s7ok4uw	2026	3	titration	titration	NN
cord-001835-0s7ok4uw	2026	4	,	,	,
cord-001835-0s7ok4uw	2026	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2026	6	observed	observe	VBD
cord-001835-0s7ok4uw	2026	7	by	by	IN
cord-001835-0s7ok4uw	2026	8	CD	CD	NNP
cord-001835-0s7ok4uw	2026	9	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2026	10	that	that	IN
cord-001835-0s7ok4uw	2026	11	strategic	strategic	JJ
cord-001835-0s7ok4uw	2026	12	incorporation	incorporation	NN
cord-001835-0s7ok4uw	2026	13	of	of	IN
cord-001835-0s7ok4uw	2026	14	D	d	NN
cord-001835-0s7ok4uw	2026	15	-	-	HYPH
cord-001835-0s7ok4uw	2026	16	amino	amino	JJ
cord-001835-0s7ok4uw	2026	17	acids	acid	NNS
cord-001835-0s7ok4uw	2026	18	at	at	IN
cord-001835-0s7ok4uw	2026	19	positions	position	NNS
cord-001835-0s7ok4uw	2026	20	15	15	CD
cord-001835-0s7ok4uw	2026	21	and	and	CC
cord-001835-0s7ok4uw	2026	22	16	16	CD
cord-001835-0s7ok4uw	2026	23	leads	lead	VBZ
cord-001835-0s7ok4uw	2026	24	to	to	IN
cord-001835-0s7ok4uw	2026	25	an	an	DT
cord-001835-0s7ok4uw	2026	26	IAPP	IAPP	NNP
cord-001835-0s7ok4uw	2026	27	derivative	derivative	JJ
cord-001835-0s7ok4uw	2026	28	(	(	-LRB-
cord-001835-0s7ok4uw	2026	29	dIAPP	diapp	NN
cord-001835-0s7ok4uw	2026	30	)	)	-RRB-
cord-001835-0s7ok4uw	2026	31	that	that	WDT
cord-001835-0s7ok4uw	2026	32	can	can	MD
cord-001835-0s7ok4uw	2026	33	not	not	RB
cord-001835-0s7ok4uw	2026	34	fold	fold	VB
cord-001835-0s7ok4uw	2026	35	into	into	IN
cord-001835-0s7ok4uw	2026	36	a	a	DT
cord-001835-0s7ok4uw	2026	37	helix	helix	NN
cord-001835-0s7ok4uw	2026	38	.	.	.
cord-001835-0s7ok4uw	2027	1	In	in	IN
cord-001835-0s7ok4uw	2027	2	homogeneous	homogeneous	JJ
cord-001835-0s7ok4uw	2027	3	solution	solution	NN
cord-001835-0s7ok4uw	2027	4	,	,	,
cord-001835-0s7ok4uw	2027	5	hIAPP	hIAPP	NNP
cord-001835-0s7ok4uw	2027	6	and	and	CC
cord-001835-0s7ok4uw	2027	7	dIAPP	dIAPP	NNP
cord-001835-0s7ok4uw	2027	8	show	show	VBP
cord-001835-0s7ok4uw	2027	9	similar	similar	JJ
cord-001835-0s7ok4uw	2027	10	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2027	11	of	of	IN
cord-001835-0s7ok4uw	2027	12	fibrillization	fibrillization	NN
cord-001835-0s7ok4uw	2027	13	,	,	,
cord-001835-0s7ok4uw	2027	14	as	as	IN
cord-001835-0s7ok4uw	2027	15	measured	measure	VBN
cord-001835-0s7ok4uw	2027	16	by	by	IN
cord-001835-0s7ok4uw	2027	17	Thioflavin	Thioflavin	NNP
cord-001835-0s7ok4uw	2027	18	T	T	NNP
cord-001835-0s7ok4uw	2027	19	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2027	20	.	.	.
cord-001835-0s7ok4uw	2028	1	Although	although	IN
cord-001835-0s7ok4uw	2028	2	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2028	3	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2028	4	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2028	5	display	display	VBP
cord-001835-0s7ok4uw	2028	6	different	different	JJ
cord-001835-0s7ok4uw	2028	7	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	2028	8	by	by	IN
cord-001835-0s7ok4uw	2028	9	AFM	AFM	NNP
cord-001835-0s7ok4uw	2028	10	,	,	,
cord-001835-0s7ok4uw	2028	11	IAPP	IAPP	NNP
cord-001835-0s7ok4uw	2028	12	and	and	CC
cord-001835-0s7ok4uw	2028	13	dIAPP	dIAPP	NNP
cord-001835-0s7ok4uw	2028	14	are	be	VBP
cord-001835-0s7ok4uw	2028	15	able	able	JJ
cord-001835-0s7ok4uw	2028	16	to	to	TO
cord-001835-0s7ok4uw	2028	17	self	self	NN
cord-001835-0s7ok4uw	2028	18	-	-	HYPH
cord-001835-0s7ok4uw	2028	19	associate	associate	NN
cord-001835-0s7ok4uw	2028	20	to	to	TO
cord-001835-0s7ok4uw	2028	21	form	form	VB
cord-001835-0s7ok4uw	2028	22	amyloids	amyloids	NNP
cord-001835-0s7ok4uw	2028	23	when	when	WRB
cord-001835-0s7ok4uw	2028	24	mixed	mix	VBN
cord-001835-0s7ok4uw	2028	25	together	together	RB
cord-001835-0s7ok4uw	2028	26	and	and	CC
cord-001835-0s7ok4uw	2028	27	when	when	WRB
cord-001835-0s7ok4uw	2028	28	seeded	seed	VBN
cord-001835-0s7ok4uw	2028	29	with	with	IN
cord-001835-0s7ok4uw	2028	30	one	one	CD
cord-001835-0s7ok4uw	2028	31	another	another	DT
cord-001835-0s7ok4uw	2028	32	.	.	.
cord-001835-0s7ok4uw	2029	1	Studies	study	NNS
cord-001835-0s7ok4uw	2029	2	in	in	IN
cord-001835-0s7ok4uw	2029	3	heterogeneous	heterogeneous	JJ
cord-001835-0s7ok4uw	2029	4	environment	environment	NN
cord-001835-0s7ok4uw	2029	5	,	,	,
cord-001835-0s7ok4uw	2029	6	notably	notably	RB
cord-001835-0s7ok4uw	2029	7	in	in	IN
cord-001835-0s7ok4uw	2029	8	presence	presence	NN
cord-001835-0s7ok4uw	2029	9	of	of	IN
cord-001835-0s7ok4uw	2029	10	glycosaminoglycans	glycosaminoglycan	NNS
cord-001835-0s7ok4uw	2029	11	and	and	CC
cord-001835-0s7ok4uw	2029	12	model	model	NN
cord-001835-0s7ok4uw	2029	13	membranes	membrane	NNS
cord-001835-0s7ok4uw	2029	14	of	of	IN
cord-001835-0s7ok4uw	2029	15	DOPC	DOPC	NNP
cord-001835-0s7ok4uw	2029	16	/	/	SYM
cord-001835-0s7ok4uw	2029	17	DOPG	DOPG	NNP
cord-001835-0s7ok4uw	2029	18	(	(	-LRB-
cord-001835-0s7ok4uw	2029	19	7:3	7:3	CD
cord-001835-0s7ok4uw	2029	20	)	)	-RRB-
cord-001835-0s7ok4uw	2029	21	,	,	,
cord-001835-0s7ok4uw	2029	22	showed	show	VBD
cord-001835-0s7ok4uw	2029	23	a	a	DT
cord-001835-0s7ok4uw	2029	24	helical	helical	JJ
cord-001835-0s7ok4uw	2029	25	intermediate	intermediate	NN
cord-001835-0s7ok4uw	2029	26	for	for	IN
cord-001835-0s7ok4uw	2029	27	hIAPP	hIAPP	NNP
cord-001835-0s7ok4uw	2029	28	while	while	IN
cord-001835-0s7ok4uw	2029	29	only	only	RB
cord-001835-0s7ok4uw	2029	30	a	a	DT
cord-001835-0s7ok4uw	2029	31	beta	beta	JJ
cord-001835-0s7ok4uw	2029	32	-	-	HYPH
cord-001835-0s7ok4uw	2029	33	sheet	sheet	NN
cord-001835-0s7ok4uw	2029	34	secondary	secondary	JJ
cord-001835-0s7ok4uw	2029	35	structure	structure	NN
cord-001835-0s7ok4uw	2029	36	was	be	VBD
cord-001835-0s7ok4uw	2029	37	apparent	apparent	JJ
cord-001835-0s7ok4uw	2029	38	for	for	IN
cord-001835-0s7ok4uw	2029	39	dIAPP	dIAPP	NNP
cord-001835-0s7ok4uw	2029	40	.	.	.
cord-001835-0s7ok4uw	2030	1	While	while	IN
cord-001835-0s7ok4uw	2030	2	the	the	DT
cord-001835-0s7ok4uw	2030	3	rate	rate	NN
cord-001835-0s7ok4uw	2030	4	of	of	IN
cord-001835-0s7ok4uw	2030	5	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2030	6	fibril	fibril	NNP
cord-001835-0s7ok4uw	2030	7	formation	formation	NN
cord-001835-0s7ok4uw	2030	8	was	be	VBD
cord-001835-0s7ok4uw	2030	9	increased	increase	VBN
cord-001835-0s7ok4uw	2030	10	for	for	IN
cord-001835-0s7ok4uw	2030	11	both	both	DT
cord-001835-0s7ok4uw	2030	12	peptides	peptide	NNS
cord-001835-0s7ok4uw	2030	13	,	,	,
cord-001835-0s7ok4uw	2030	14	dIAPP	dIAPP	NNP
cord-001835-0s7ok4uw	2030	15	was	be	VBD
cord-001835-0s7ok4uw	2030	16	drastically	drastically	RB
cord-001835-0s7ok4uw	2030	17	affected	affect	VBN
cord-001835-0s7ok4uw	2030	18	by	by	IN
cord-001835-0s7ok4uw	2030	19	these	these	DT
cord-001835-0s7ok4uw	2030	20	anionic	anionic	JJ
cord-001835-0s7ok4uw	2030	21	biomolecules	biomolecule	NNS
cord-001835-0s7ok4uw	2030	22	with	with	IN
cord-001835-0s7ok4uw	2030	23	an	an	DT
cord-001835-0s7ok4uw	2030	24	absence	absence	NN
cord-001835-0s7ok4uw	2030	25	of	of	IN
cord-001835-0s7ok4uw	2030	26	lag	lag	NN
cord-001835-0s7ok4uw	2030	27	phase	phase	NN
cord-001835-0s7ok4uw	2030	28	.	.	.
cord-001835-0s7ok4uw	2031	1	The	the	DT
cord-001835-0s7ok4uw	2031	2	incapacity	incapacity	NN
cord-001835-0s7ok4uw	2031	3	of	of	IN
cord-001835-0s7ok4uw	2031	4	adopting	adopt	VBG
cord-001835-0s7ok4uw	2031	5	a	a	DT
cord-001835-0s7ok4uw	2031	6	transient	transient	JJ
cord-001835-0s7ok4uw	2031	7	helical	helical	JJ
cord-001835-0s7ok4uw	2031	8	conformation	conformation	NN
cord-001835-0s7ok4uw	2031	9	accentuates	accentuate	VBZ
cord-001835-0s7ok4uw	2031	10	cell	cell	NN
cord-001835-0s7ok4uw	2031	11	toxicity	toxicity	NN
cord-001835-0s7ok4uw	2031	12	,	,	,
cord-001835-0s7ok4uw	2031	13	supported	support	VBN
cord-001835-0s7ok4uw	2031	14	by	by	IN
cord-001835-0s7ok4uw	2031	15	the	the	DT
cord-001835-0s7ok4uw	2031	16	caspase	caspase	NN
cord-001835-0s7ok4uw	2031	17	3/7	3/7	CD
cord-001835-0s7ok4uw	2031	18	activation	activation	NN
cord-001835-0s7ok4uw	2031	19	level	level	NN
cord-001835-0s7ok4uw	2031	20	and	and	CC
cord-001835-0s7ok4uw	2031	21	the	the	DT
cord-001835-0s7ok4uw	2031	22	increase	increase	NN
cord-001835-0s7ok4uw	2031	23	in	in	IN
cord-001835-0s7ok4uw	2031	24	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	2031	25	calcium	calcium	NN
cord-001835-0s7ok4uw	2031	26	level	level	NN
cord-001835-0s7ok4uw	2031	27	.	.	.
cord-001835-0s7ok4uw	2032	1	Overall	overall	RB
cord-001835-0s7ok4uw	2032	2	,	,	,
cord-001835-0s7ok4uw	2032	3	this	this	DT
cord-001835-0s7ok4uw	2032	4	study	study	NN
cord-001835-0s7ok4uw	2032	5	indicates	indicate	VBZ
cord-001835-0s7ok4uw	2032	6	that	that	IN
cord-001835-0s7ok4uw	2032	7	the	the	DT
cord-001835-0s7ok4uw	2032	8	helical	helical	JJ
cord-001835-0s7ok4uw	2032	9	intermediate	intermediate	NN
cord-001835-0s7ok4uw	2032	10	is	be	VBZ
cord-001835-0s7ok4uw	2032	11	offpathway	offpathway	JJ
cord-001835-0s7ok4uw	2032	12	to	to	IN
cord-001835-0s7ok4uw	2032	13	IAPP	IAPP	NNP
cord-001835-0s7ok4uw	2032	14	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2032	15	formation	formation	NN
cord-001835-0s7ok4uw	2032	16	and	and	CC
cord-001835-0s7ok4uw	2032	17	offers	offer	VBZ
cord-001835-0s7ok4uw	2032	18	novel	novel	JJ
cord-001835-0s7ok4uw	2032	19	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	2032	20	insights	insight	NNS
cord-001835-0s7ok4uw	2032	21	for	for	IN
cord-001835-0s7ok4uw	2032	22	the	the	DT
cord-001835-0s7ok4uw	2032	23	development	development	NN
cord-001835-0s7ok4uw	2032	24	of	of	IN
cord-001835-0s7ok4uw	2032	25	molecular	molecular	JJ
cord-001835-0s7ok4uw	2032	26	identities	identity	NNS
cord-001835-0s7ok4uw	2032	27	modulating	modulate	VBG
cord-001835-0s7ok4uw	2032	28	peptide	peptide	JJ
cord-001835-0s7ok4uw	2032	29	self	self	NN
cord-001835-0s7ok4uw	2032	30	-	-	HYPH
cord-001835-0s7ok4uw	2032	31	assembly	assembly	NN
cord-001835-0s7ok4uw	2032	32	and	and	CC
cord-001835-0s7ok4uw	2032	33	IAPP	IAPP	NNP
cord-001835-0s7ok4uw	2032	34	-	-	HYPH
cord-001835-0s7ok4uw	2032	35	induced	induce	VBN
cord-001835-0s7ok4uw	2032	36	cytotoxicity	cytotoxicity	NN
cord-001835-0s7ok4uw	2032	37	.	.	.
cord-001835-0s7ok4uw	2033	1	For	for	IN
cord-001835-0s7ok4uw	2033	2	an	an	DT
cord-001835-0s7ok4uw	2033	3	organism	organism	NN
cord-001835-0s7ok4uw	2033	4	to	to	TO
cord-001835-0s7ok4uw	2033	5	survive	survive	VB
cord-001835-0s7ok4uw	2033	6	,	,	,
cord-001835-0s7ok4uw	2033	7	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2033	8	proteins	protein	NNS
cord-001835-0s7ok4uw	2033	9	must	must	MD
cord-001835-0s7ok4uw	2033	10	adopt	adopt	VB
cord-001835-0s7ok4uw	2033	11	complex	complex	JJ
cord-001835-0s7ok4uw	2033	12	conformations	conformation	NNS
cord-001835-0s7ok4uw	2033	13	in	in	IN
cord-001835-0s7ok4uw	2033	14	a	a	DT
cord-001835-0s7ok4uw	2033	15	challenging	challenging	JJ
cord-001835-0s7ok4uw	2033	16	environment	environment	NN
cord-001835-0s7ok4uw	2033	17	where	where	WRB
cord-001835-0s7ok4uw	2033	18	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	2033	19	crowding	crowding	NN
cord-001835-0s7ok4uw	2033	20	can	can	MD
cord-001835-0s7ok4uw	2033	21	derail	derail	VB
cord-001835-0s7ok4uw	2033	22	even	even	RB
cord-001835-0s7ok4uw	2033	23	robust	robust	JJ
cord-001835-0s7ok4uw	2033	24	biological	biological	JJ
cord-001835-0s7ok4uw	2033	25	pathways	pathway	NNS
cord-001835-0s7ok4uw	2033	26	.	.	.
cord-001835-0s7ok4uw	2034	1	The	the	DT
cord-001835-0s7ok4uw	2034	2	situation	situation	NN
cord-001835-0s7ok4uw	2034	3	is	be	VBZ
cord-001835-0s7ok4uw	2034	4	perilous	perilous	JJ
cord-001835-0s7ok4uw	2034	5	:	:	:
cord-001835-0s7ok4uw	2034	6	many	many	JJ
cord-001835-0s7ok4uw	2034	7	diseases	disease	NNS
cord-001835-0s7ok4uw	2034	8	arise	arise	VBP
cord-001835-0s7ok4uw	2034	9	from	from	IN
cord-001835-0s7ok4uw	2034	10	improper	improper	JJ
cord-001835-0s7ok4uw	2034	11	folding	folding	NN
cord-001835-0s7ok4uw	2034	12	of	of	IN
cord-001835-0s7ok4uw	2034	13	just	just	RB
cord-001835-0s7ok4uw	2034	14	a	a	DT
cord-001835-0s7ok4uw	2034	15	single	single	JJ
cord-001835-0s7ok4uw	2034	16	protein	protein	NN
cord-001835-0s7ok4uw	2034	17	.	.	.
cord-001835-0s7ok4uw	2035	1	To	to	TO
cord-001835-0s7ok4uw	2035	2	cope	cope	VB
cord-001835-0s7ok4uw	2035	3	,	,	,
cord-001835-0s7ok4uw	2035	4	cells	cell	NNS
cord-001835-0s7ok4uw	2035	5	employ	employ	VBP
cord-001835-0s7ok4uw	2035	6	a	a	DT
cord-001835-0s7ok4uw	2035	7	repertoire	repertoire	NN
cord-001835-0s7ok4uw	2035	8	of	of	IN
cord-001835-0s7ok4uw	2035	9	molecular	molecular	JJ
cord-001835-0s7ok4uw	2035	10	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	2035	11	and	and	CC
cord-001835-0s7ok4uw	2035	12	remodeling	remodeling	NN
cord-001835-0s7ok4uw	2035	13	factors	factor	NNS
cord-001835-0s7ok4uw	2035	14	that	that	WDT
cord-001835-0s7ok4uw	2035	15	usher	usher	VBP
cord-001835-0s7ok4uw	2035	16	unfolded	unfold	VBD
cord-001835-0s7ok4uw	2035	17	proteins	protein	NNS
cord-001835-0s7ok4uw	2035	18	into	into	IN
cord-001835-0s7ok4uw	2035	19	active	active	JJ
cord-001835-0s7ok4uw	2035	20	conformations	conformation	NNS
cord-001835-0s7ok4uw	2035	21	,	,	,
cord-001835-0s7ok4uw	2035	22	sequester	sequester	VB
cord-001835-0s7ok4uw	2035	23	them	-PRON-	PRP
cord-001835-0s7ok4uw	2035	24	,	,	,
cord-001835-0s7ok4uw	2035	25	or	or	CC
cord-001835-0s7ok4uw	2035	26	target	target	VB
cord-001835-0s7ok4uw	2035	27	them	-PRON-	PRP
cord-001835-0s7ok4uw	2035	28	for	for	IN
cord-001835-0s7ok4uw	2035	29	degradation	degradation	NN
cord-001835-0s7ok4uw	2035	30	.	.	.
cord-001835-0s7ok4uw	2036	1	Yet	yet	CC
cord-001835-0s7ok4uw	2036	2	,	,	,
cord-001835-0s7ok4uw	2036	3	not	not	RB
cord-001835-0s7ok4uw	2036	4	all	all	DT
cord-001835-0s7ok4uw	2036	5	aggregated	aggregate	VBN
cord-001835-0s7ok4uw	2036	6	proteins	protein	NNS
cord-001835-0s7ok4uw	2036	7	are	be	VBP
cord-001835-0s7ok4uw	2036	8	the	the	DT
cord-001835-0s7ok4uw	2036	9	result	result	NN
cord-001835-0s7ok4uw	2036	10	of	of	IN
cord-001835-0s7ok4uw	2036	11	mis	mis	NN
cord-001835-0s7ok4uw	2036	12	-	-	HYPH
cord-001835-0s7ok4uw	2036	13	folding	folding	NN
cord-001835-0s7ok4uw	2036	14	.	.	.
cord-001835-0s7ok4uw	2037	1	Yeast	yeast	NN
cord-001835-0s7ok4uw	2037	2	prions	prion	NNS
cord-001835-0s7ok4uw	2037	3	are	be	VBP
cord-001835-0s7ok4uw	2037	4	self	self	NN
cord-001835-0s7ok4uw	2037	5	-	-	HYPH
cord-001835-0s7ok4uw	2037	6	templating	template	VBG
cord-001835-0s7ok4uw	2037	7	protein	protein	NN
cord-001835-0s7ok4uw	2037	8	-	-	HYPH
cord-001835-0s7ok4uw	2037	9	based	base	VBN
cord-001835-0s7ok4uw	2037	10	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	2037	11	of	of	IN
cord-001835-0s7ok4uw	2037	12	inheritance	inheritance	NN
cord-001835-0s7ok4uw	2037	13	that	that	WDT
cord-001835-0s7ok4uw	2037	14	rely	rely	VBP
cord-001835-0s7ok4uw	2037	15	upon	upon	IN
cord-001835-0s7ok4uw	2037	16	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	2037	17	for	for	IN
cord-001835-0s7ok4uw	2037	18	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2037	19	propagation	propagation	NN
cord-001835-0s7ok4uw	2037	20	.	.	.
cord-001835-0s7ok4uw	2038	1	The	the	DT
cord-001835-0s7ok4uw	2038	2	best	well	RBS
cord-001835-0s7ok4uw	2038	3	studied	study	VBN
cord-001835-0s7ok4uw	2038	4	of	of	IN
cord-001835-0s7ok4uw	2038	5	these	these	DT
cord-001835-0s7ok4uw	2038	6	is	be	VBZ
cord-001835-0s7ok4uw	2038	7	the	the	DT
cord-001835-0s7ok4uw	2038	8	prion	prion	NN
cord-001835-0s7ok4uw	2038	9	domain	domain	NN
cord-001835-0s7ok4uw	2038	10	(	(	-LRB-
cord-001835-0s7ok4uw	2038	11	NM	NM	NNP
cord-001835-0s7ok4uw	2038	12	)	)	-RRB-
cord-001835-0s7ok4uw	2038	13	of	of	IN
cord-001835-0s7ok4uw	2038	14	Sup35	Sup35	NNP
cord-001835-0s7ok4uw	2038	15	,	,	,
cord-001835-0s7ok4uw	2038	16	which	which	WDT
cord-001835-0s7ok4uw	2038	17	forms	form	VBZ
cord-001835-0s7ok4uw	2038	18	an	an	DT
cord-001835-0s7ok4uw	2038	19	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2038	20	that	that	WDT
cord-001835-0s7ok4uw	2038	21	can	can	MD
cord-001835-0s7ok4uw	2038	22	adopt	adopt	VB
cord-001835-0s7ok4uw	2038	23	several	several	JJ
cord-001835-0s7ok4uw	2038	24	distinct	distinct	JJ
cord-001835-0s7ok4uw	2038	25	conformations	conformation	NNS
cord-001835-0s7ok4uw	2038	26	(	(	-LRB-
cord-001835-0s7ok4uw	2038	27	strains	strain	NNS
cord-001835-0s7ok4uw	2038	28	)	)	-RRB-
cord-001835-0s7ok4uw	2038	29	that	that	WDT
cord-001835-0s7ok4uw	2038	30	produce	produce	VBP
cord-001835-0s7ok4uw	2038	31	distinct	distinct	JJ
cord-001835-0s7ok4uw	2038	32	phenotypes	phenotype	NNS
cord-001835-0s7ok4uw	2038	33	.	.	.
cord-001835-0s7ok4uw	2039	1	Using	use	VBG
cord-001835-0s7ok4uw	2039	2	genetic	genetic	JJ
cord-001835-0s7ok4uw	2039	3	,	,	,
cord-001835-0s7ok4uw	2039	4	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	2039	5	,	,	,
cord-001835-0s7ok4uw	2039	6	spectroscopic	spectroscopic	JJ
cord-001835-0s7ok4uw	2039	7	,	,	,
cord-001835-0s7ok4uw	2039	8	and	and	CC
cord-001835-0s7ok4uw	2039	9	solid	solid	JJ
cord-001835-0s7ok4uw	2039	10	state	state	NN
cord-001835-0s7ok4uw	2039	11	NMR	nmr	NN
cord-001835-0s7ok4uw	2039	12	techniques	technique	NNS
cord-001835-0s7ok4uw	2039	13	,	,	,
cord-001835-0s7ok4uw	2039	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	2039	15	investigated	investigate	VBD
cord-001835-0s7ok4uw	2039	16	the	the	DT
cord-001835-0s7ok4uw	2039	17	structural	structural	JJ
cord-001835-0s7ok4uw	2039	18	and	and	CC
cord-001835-0s7ok4uw	2039	19	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2039	20	underpinnings	underpinning	NNS
cord-001835-0s7ok4uw	2039	21	of	of	IN
cord-001835-0s7ok4uw	2039	22	Sup35	Sup35	NNP
cord-001835-0s7ok4uw	2039	23	amyloids	amyloids	NNP
cord-001835-0s7ok4uw	2039	24	and	and	CC
cord-001835-0s7ok4uw	2039	25	found	find	VBD
cord-001835-0s7ok4uw	2039	26	that	that	IN
cord-001835-0s7ok4uw	2039	27	prion	prion	NN
cord-001835-0s7ok4uw	2039	28	strains	strain	NNS
cord-001835-0s7ok4uw	2039	29	differ	differ	VBP
cord-001835-0s7ok4uw	2039	30	in	in	IN
cord-001835-0s7ok4uw	2039	31	both	both	CC
cord-001835-0s7ok4uw	2039	32	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2039	33	atomic	atomic	JJ
cord-001835-0s7ok4uw	2039	34	structure	structure	NN
cord-001835-0s7ok4uw	2039	35	as	as	RB
cord-001835-0s7ok4uw	2039	36	well	well	RB
cord-001835-0s7ok4uw	2039	37	as	as	IN
cord-001835-0s7ok4uw	2039	38	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2039	39	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2039	40	motions	motion	NNS
cord-001835-0s7ok4uw	2039	41	.	.	.
cord-001835-0s7ok4uw	2040	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	2040	2	,	,	,
cord-001835-0s7ok4uw	2040	3	these	these	DT
cord-001835-0s7ok4uw	2040	4	mobility	mobility	NN
cord-001835-0s7ok4uw	2040	5	differences	difference	NNS
cord-001835-0s7ok4uw	2040	6	correlate	correlate	VBP
cord-001835-0s7ok4uw	2040	7	with	with	IN
cord-001835-0s7ok4uw	2040	8	differences	difference	NNS
cord-001835-0s7ok4uw	2040	9	in	in	IN
cord-001835-0s7ok4uw	2040	10	the	the	DT
cord-001835-0s7ok4uw	2040	11	interaction	interaction	NN
cord-001835-0s7ok4uw	2040	12	with	with	IN
cord-001835-0s7ok4uw	2040	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	2040	14	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	2040	15	in	in	IN
cord-001835-0s7ok4uw	2040	16	vivo	vivo	NN
cord-001835-0s7ok4uw	2040	17	.	.	.
cord-001835-0s7ok4uw	2041	1	Limitations	limitation	NNS
cord-001835-0s7ok4uw	2041	2	on	on	IN
cord-001835-0s7ok4uw	2041	3	the	the	DT
cord-001835-0s7ok4uw	2041	4	specificity	specificity	NN
cord-001835-0s7ok4uw	2041	5	and	and	CC
cord-001835-0s7ok4uw	2041	6	sensitivity	sensitivity	NN
cord-001835-0s7ok4uw	2041	7	of	of	IN
cord-001835-0s7ok4uw	2041	8	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	2041	9	techniques	technique	NNS
cord-001835-0s7ok4uw	2041	10	typically	typically	RB
cord-001835-0s7ok4uw	2041	11	restrict	restrict	VBP
cord-001835-0s7ok4uw	2041	12	structural	structural	JJ
cord-001835-0s7ok4uw	2041	13	investigations	investigation	NNS
cord-001835-0s7ok4uw	2041	14	to	to	IN
cord-001835-0s7ok4uw	2041	15	purified	purify	VBN
cord-001835-0s7ok4uw	2041	16	systems	system	NNS
cord-001835-0s7ok4uw	2041	17	at	at	IN
cord-001835-0s7ok4uw	2041	18	concentrations	concentration	NNS
cord-001835-0s7ok4uw	2041	19	that	that	WDT
cord-001835-0s7ok4uw	2041	20	are	be	VBP
cord-001835-0s7ok4uw	2041	21	orders	order	NNS
cord-001835-0s7ok4uw	2041	22	of	of	IN
cord-001835-0s7ok4uw	2041	23	magnitude	magnitude	NN
cord-001835-0s7ok4uw	2041	24	above	above	IN
cord-001835-0s7ok4uw	2041	25	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	2041	26	levels	level	NNS
cord-001835-0s7ok4uw	2041	27	.	.	.
cord-001835-0s7ok4uw	2042	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	2042	2	,	,	,
cord-001835-0s7ok4uw	2042	3	I	-PRON-	PRP
cord-001835-0s7ok4uw	2042	4	developed	develop	VBD
cord-001835-0s7ok4uw	2042	5	an	an	DT
cord-001835-0s7ok4uw	2042	6	approach	approach	NN
cord-001835-0s7ok4uw	2042	7	to	to	TO
cord-001835-0s7ok4uw	2042	8	apply	apply	VB
cord-001835-0s7ok4uw	2042	9	a	a	DT
cord-001835-0s7ok4uw	2042	10	sensitivity	sensitivity	NN
cord-001835-0s7ok4uw	2042	11	-	-	HYPH
cord-001835-0s7ok4uw	2042	12	enhancement	enhancement	NN
cord-001835-0s7ok4uw	2042	13	technique	technique	NN
cord-001835-0s7ok4uw	2042	14	for	for	IN
cord-001835-0s7ok4uw	2042	15	NMR	NMR	NNP
cord-001835-0s7ok4uw	2042	16	,	,	,
cord-001835-0s7ok4uw	2042	17	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2042	18	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	2042	19	polarization	polarization	NN
cord-001835-0s7ok4uw	2042	20	(	(	-LRB-
cord-001835-0s7ok4uw	2042	21	DNP	DNP	NNP
cord-001835-0s7ok4uw	2042	22	)	)	-RRB-
cord-001835-0s7ok4uw	2042	23	,	,	,
cord-001835-0s7ok4uw	2042	24	to	to	TO
cord-001835-0s7ok4uw	2042	25	investigate	investigate	VB
cord-001835-0s7ok4uw	2042	26	interactions	interaction	NNS
cord-001835-0s7ok4uw	2042	27	between	between	IN
cord-001835-0s7ok4uw	2042	28	Sup35	Sup35	NNP
cord-001835-0s7ok4uw	2042	29	and	and	CC
cord-001835-0s7ok4uw	2042	30	molecular	molecular	JJ
cord-001835-0s7ok4uw	2042	31	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	2042	32	at	at	IN
cord-001835-0s7ok4uw	2042	33	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	2042	34	concentrations	concentration	NNS
cord-001835-0s7ok4uw	2042	35	in	in	IN
cord-001835-0s7ok4uw	2042	36	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2042	37	native	native	JJ
cord-001835-0s7ok4uw	2042	38	environments	environment	NNS
cord-001835-0s7ok4uw	2042	39	.	.	.
cord-001835-0s7ok4uw	2043	1	Critically	critically	RB
cord-001835-0s7ok4uw	2043	2	,	,	,
cord-001835-0s7ok4uw	2043	3	I	-PRON-	PRP
cord-001835-0s7ok4uw	2043	4	found	find	VBD
cord-001835-0s7ok4uw	2043	5	that	that	IN
cord-001835-0s7ok4uw	2043	6	the	the	DT
cord-001835-0s7ok4uw	2043	7	cellular	cellular	JJ
cord-001835-0s7ok4uw	2043	8	environment	environment	NN
cord-001835-0s7ok4uw	2043	9	induced	induce	VBD
cord-001835-0s7ok4uw	2043	10	structural	structural	JJ
cord-001835-0s7ok4uw	2043	11	changes	change	NNS
cord-001835-0s7ok4uw	2043	12	in	in	IN
cord-001835-0s7ok4uw	2043	13	a	a	DT
cord-001835-0s7ok4uw	2043	14	region	region	NN
cord-001835-0s7ok4uw	2043	15	of	of	IN
cord-001835-0s7ok4uw	2043	16	Sup35	Sup35	NNP
cord-001835-0s7ok4uw	2043	17	that	that	WDT
cord-001835-0s7ok4uw	2043	18	is	be	VBZ
cord-001835-0s7ok4uw	2043	19	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2043	20	disordered	disordered	JJ
cord-001835-0s7ok4uw	2043	21	in	in	IN
cord-001835-0s7ok4uw	2043	22	purified	purify	VBN
cord-001835-0s7ok4uw	2043	23	samples	sample	NNS
cord-001835-0s7ok4uw	2043	24	but	but	CC
cord-001835-0s7ok4uw	2043	25	known	know	VBN
cord-001835-0s7ok4uw	2043	26	genetically	genetically	RB
cord-001835-0s7ok4uw	2043	27	to	to	TO
cord-001835-0s7ok4uw	2043	28	influence	influence	VB
cord-001835-0s7ok4uw	2043	29	prion	prion	NN
cord-001835-0s7ok4uw	2043	30	propagation	propagation	NN
cord-001835-0s7ok4uw	2043	31	from	from	IN
cord-001835-0s7ok4uw	2043	32	one	one	CD
cord-001835-0s7ok4uw	2043	33	generation	generation	NN
cord-001835-0s7ok4uw	2043	34	to	to	IN
cord-001835-0s7ok4uw	2043	35	the	the	DT
cord-001835-0s7ok4uw	2043	36	next	next	JJ
cord-001835-0s7ok4uw	2043	37	.	.	.
cord-001835-0s7ok4uw	2044	1	This	this	DT
cord-001835-0s7ok4uw	2044	2	approach	approach	NN
cord-001835-0s7ok4uw	2044	3	enables	enable	VBZ
cord-001835-0s7ok4uw	2044	4	structural	structural	JJ
cord-001835-0s7ok4uw	2044	5	and	and	CC
cord-001835-0s7ok4uw	2044	6	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	2044	7	investigation	investigation	NN
cord-001835-0s7ok4uw	2044	8	of	of	IN
cord-001835-0s7ok4uw	2044	9	proteins	protein	NNS
cord-001835-0s7ok4uw	2044	10	in	in	IN
cord-001835-0s7ok4uw	2044	11	biologically	biologically	RB
cord-001835-0s7ok4uw	2044	12	relevant	relevant	JJ
cord-001835-0s7ok4uw	2044	13	contexts	contexts	NN
cord-001835-0s7ok4uw	2044	14	.	.	.
cord-001835-0s7ok4uw	2045	1	Genetic	genetic	JJ
cord-001835-0s7ok4uw	2045	2	instability	instability	NN
cord-001835-0s7ok4uw	2046	1	within	within	IN
cord-001835-0s7ok4uw	2046	2	regions	region	NNS
cord-001835-0s7ok4uw	2046	3	encoding	encode	VBG
cord-001835-0s7ok4uw	2046	4	repetitive	repetitive	JJ
cord-001835-0s7ok4uw	2046	5	proteins	protein	NNS
cord-001835-0s7ok4uw	2046	6	as	as	IN
cord-001835-0s7ok4uw	2046	7	a	a	DT
cord-001835-0s7ok4uw	2046	8	driver	driver	NN
cord-001835-0s7ok4uw	2046	9	of	of	IN
cord-001835-0s7ok4uw	2046	10	adaptation	adaptation	NN
cord-001835-0s7ok4uw	2046	11	Stephen	Stephen	NNP
cord-001835-0s7ok4uw	2046	12	Fuchs	Fuchs	NNP
cord-001835-0s7ok4uw	2047	1	1	1	LS
cord-001835-0s7ok4uw	2047	2	1	1	CD
cord-001835-0s7ok4uw	2047	3	More	More	JJR
cord-001835-0s7ok4uw	2047	4	than	than	IN
cord-001835-0s7ok4uw	2047	5	ten	ten	CD
cord-001835-0s7ok4uw	2047	6	percent	percent	NN
cord-001835-0s7ok4uw	2047	7	of	of	IN
cord-001835-0s7ok4uw	2047	8	all	all	DT
cord-001835-0s7ok4uw	2047	9	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	2047	10	proteins	protein	NNS
cord-001835-0s7ok4uw	2047	11	contain	contain	VBP
cord-001835-0s7ok4uw	2047	12	within	within	IN
cord-001835-0s7ok4uw	2047	13	them	-PRON-	PRP
cord-001835-0s7ok4uw	2047	14	a	a	DT
cord-001835-0s7ok4uw	2047	15	region	region	NN
cord-001835-0s7ok4uw	2047	16	of	of	IN
cord-001835-0s7ok4uw	2047	17	repetitive	repetitive	JJ
cord-001835-0s7ok4uw	2047	18	amino	amino	NN
cord-001835-0s7ok4uw	2047	19	acid	acid	NN
cord-001835-0s7ok4uw	2047	20	sequence	sequence	NN
cord-001835-0s7ok4uw	2047	21	.	.	.
cord-001835-0s7ok4uw	2048	1	These	these	DT
cord-001835-0s7ok4uw	2048	2	repetitive	repetitive	JJ
cord-001835-0s7ok4uw	2048	3	domains	domain	NNS
cord-001835-0s7ok4uw	2048	4	range	range	VBP
cord-001835-0s7ok4uw	2048	5	from	from	IN
cord-001835-0s7ok4uw	2048	6	short	short	JJ
cord-001835-0s7ok4uw	2048	7	stretches	stretch	NNS
cord-001835-0s7ok4uw	2048	8	of	of	IN
cord-001835-0s7ok4uw	2048	9	a	a	DT
cord-001835-0s7ok4uw	2048	10	single	single	JJ
cord-001835-0s7ok4uw	2048	11	amino	amino	NN
cord-001835-0s7ok4uw	2048	12	acid	acid	NN
cord-001835-0s7ok4uw	2048	13	to	to	IN
cord-001835-0s7ok4uw	2048	14	multiple	multiple	JJ
cord-001835-0s7ok4uw	2048	15	copies	copy	NNS
cord-001835-0s7ok4uw	2048	16	of	of	IN
cord-001835-0s7ok4uw	2048	17	longer	long	JJR
cord-001835-0s7ok4uw	2048	18	,	,	,
cord-001835-0s7ok4uw	2048	19	heterogeneous	heterogeneous	JJ
cord-001835-0s7ok4uw	2048	20	amino	amino	NN
cord-001835-0s7ok4uw	2048	21	acid	acid	NN
cord-001835-0s7ok4uw	2048	22	sequences	sequence	NNS
cord-001835-0s7ok4uw	2048	23	and	and	CC
cord-001835-0s7ok4uw	2048	24	generally	generally	RB
cord-001835-0s7ok4uw	2048	25	show	show	VBP
cord-001835-0s7ok4uw	2048	26	lack	lack	NN
cord-001835-0s7ok4uw	2048	27	of	of	IN
cord-001835-0s7ok4uw	2048	28	defined	define	VBN
cord-001835-0s7ok4uw	2048	29	structure	structure	NN
cord-001835-0s7ok4uw	2048	30	.	.	.
cord-001835-0s7ok4uw	2049	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	2049	2	play	play	VBP
cord-001835-0s7ok4uw	2049	3	diverse	diverse	JJ
cord-001835-0s7ok4uw	2049	4	roles	role	NNS
cord-001835-0s7ok4uw	2049	5	in	in	IN
cord-001835-0s7ok4uw	2049	6	cells	cell	NNS
cord-001835-0s7ok4uw	2049	7	including	include	VBG
cord-001835-0s7ok4uw	2049	8	acting	act	VBG
cord-001835-0s7ok4uw	2049	9	as	as	IN
cord-001835-0s7ok4uw	2049	10	structural	structural	JJ
cord-001835-0s7ok4uw	2049	11	proteins	protein	NNS
cord-001835-0s7ok4uw	2049	12	,	,	,
cord-001835-0s7ok4uw	2049	13	promoting	promote	VBG
cord-001835-0s7ok4uw	2049	14	cell	cell	NN
cord-001835-0s7ok4uw	2049	15	-	-	HYPH
cord-001835-0s7ok4uw	2049	16	cell	cell	NN
cord-001835-0s7ok4uw	2049	17	interactions	interaction	NNS
cord-001835-0s7ok4uw	2049	18	,	,	,
cord-001835-0s7ok4uw	2049	19	and	and	CC
cord-001835-0s7ok4uw	2049	20	mediating	mediate	VBG
cord-001835-0s7ok4uw	2049	21	the	the	DT
cord-001835-0s7ok4uw	2049	22	assembly	assembly	NN
cord-001835-0s7ok4uw	2049	23	of	of	IN
cord-001835-0s7ok4uw	2049	24	molecular	molecular	JJ
cord-001835-0s7ok4uw	2049	25	machines	machine	NNS
cord-001835-0s7ok4uw	2049	26	.	.	.
cord-001835-0s7ok4uw	2050	1	Tandem	tandem	JJ
cord-001835-0s7ok4uw	2050	2	repeat	repeat	NN
cord-001835-0s7ok4uw	2050	3	proteins	protein	NNS
cord-001835-0s7ok4uw	2050	4	are	be	VBP
cord-001835-0s7ok4uw	2050	5	known	know	VBN
cord-001835-0s7ok4uw	2050	6	to	to	TO
cord-001835-0s7ok4uw	2050	7	be	be	VB
cord-001835-0s7ok4uw	2050	8	variable	variable	JJ
cord-001835-0s7ok4uw	2050	9	in	in	IN
cord-001835-0s7ok4uw	2050	10	length	length	NN
cord-001835-0s7ok4uw	2050	11	within	within	IN
cord-001835-0s7ok4uw	2050	12	cellular	cellular	JJ
cord-001835-0s7ok4uw	2050	13	populations	population	NNS
cord-001835-0s7ok4uw	2050	14	although	although	IN
cord-001835-0s7ok4uw	2050	15	the	the	DT
cord-001835-0s7ok4uw	2050	16	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	2050	17	dictating	dictate	VBG
cord-001835-0s7ok4uw	2050	18	this	this	DT
cord-001835-0s7ok4uw	2050	19	variability	variability	NN
cord-001835-0s7ok4uw	2050	20	have	have	VBP
cord-001835-0s7ok4uw	2050	21	not	not	RB
cord-001835-0s7ok4uw	2050	22	been	be	VBN
cord-001835-0s7ok4uw	2050	23	elucidated	elucidate	VBN
cord-001835-0s7ok4uw	2050	24	.	.	.
cord-001835-0s7ok4uw	2051	1	Here	here	RB
cord-001835-0s7ok4uw	2051	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2051	3	describe	describe	VBP
cord-001835-0s7ok4uw	2051	4	work	work	NN
cord-001835-0s7ok4uw	2051	5	uncovering	uncover	VBG
cord-001835-0s7ok4uw	2051	6	specific	specific	JJ
cord-001835-0s7ok4uw	2051	7	features	feature	NNS
cord-001835-0s7ok4uw	2051	8	within	within	IN
cord-001835-0s7ok4uw	2051	9	the	the	DT
cord-001835-0s7ok4uw	2051	10	coding	code	VBG
cord-001835-0s7ok4uw	2051	11	sequences	sequence	NNS
cord-001835-0s7ok4uw	2051	12	of	of	IN
cord-001835-0s7ok4uw	2051	13	repetitive	repetitive	JJ
cord-001835-0s7ok4uw	2051	14	proteins	protein	NNS
cord-001835-0s7ok4uw	2051	15	that	that	WDT
cord-001835-0s7ok4uw	2051	16	contribute	contribute	VBP
cord-001835-0s7ok4uw	2051	17	to	to	TO
cord-001835-0s7ok4uw	2051	18	tandem	tandem	JJ
cord-001835-0s7ok4uw	2051	19	repeat	repeat	NN
cord-001835-0s7ok4uw	2051	20	instability	instability	NN
cord-001835-0s7ok4uw	2051	21	in	in	IN
cord-001835-0s7ok4uw	2051	22	yeast	yeast	NN
cord-001835-0s7ok4uw	2051	23	.	.	.
cord-001835-0s7ok4uw	2052	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	2052	2	,	,	,
cord-001835-0s7ok4uw	2052	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2052	4	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	2052	5	that	that	IN
cord-001835-0s7ok4uw	2052	6	cells	cell	NNS
cord-001835-0s7ok4uw	2052	7	will	will	MD
cord-001835-0s7ok4uw	2052	8	expand	expand	VB
cord-001835-0s7ok4uw	2052	9	and/or	and/or	CC
cord-001835-0s7ok4uw	2052	10	contract	contract	VB
cord-001835-0s7ok4uw	2052	11	repetitive	repetitive	JJ
cord-001835-0s7ok4uw	2052	12	regions	region	NNS
cord-001835-0s7ok4uw	2052	13	in	in	IN
cord-001835-0s7ok4uw	2052	14	order	order	NN
cord-001835-0s7ok4uw	2052	15	to	to	TO
cord-001835-0s7ok4uw	2052	16	adapt	adapt	VB
cord-001835-0s7ok4uw	2052	17	to	to	IN
cord-001835-0s7ok4uw	2052	18	environmental	environmental	JJ
cord-001835-0s7ok4uw	2052	19	stresses	stress	NNS
cord-001835-0s7ok4uw	2052	20	and	and	CC
cord-001835-0s7ok4uw	2052	21	describe	describe	VB
cord-001835-0s7ok4uw	2052	22	a	a	DT
cord-001835-0s7ok4uw	2052	23	role	role	NN
cord-001835-0s7ok4uw	2052	24	for	for	IN
cord-001835-0s7ok4uw	2052	25	DNA	dna	NN
cord-001835-0s7ok4uw	2052	26	repair	repair	NN
cord-001835-0s7ok4uw	2052	27	proteins	protein	NNS
cord-001835-0s7ok4uw	2052	28	in	in	IN
cord-001835-0s7ok4uw	2052	29	this	this	DT
cord-001835-0s7ok4uw	2052	30	process	process	NN
cord-001835-0s7ok4uw	2052	31	.	.	.
cord-001835-0s7ok4uw	2053	1	Lastly	lastly	RB
cord-001835-0s7ok4uw	2053	2	,	,	,
cord-001835-0s7ok4uw	2053	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2053	4	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	2053	5	how	how	WRB
cord-001835-0s7ok4uw	2053	6	these	these	DT
cord-001835-0s7ok4uw	2053	7	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	2053	8	are	be	VBP
cord-001835-0s7ok4uw	2053	9	likely	likely	RB
cord-001835-0s7ok4uw	2053	10	conserved	conserve	VBN
cord-001835-0s7ok4uw	2053	11	in	in	IN
cord-001835-0s7ok4uw	2053	12	higher	high	JJR
cord-001835-0s7ok4uw	2053	13	eukaryotes	eukaryote	NNS
cord-001835-0s7ok4uw	2053	14	,	,	,
cord-001835-0s7ok4uw	2053	15	including	include	VBG
cord-001835-0s7ok4uw	2053	16	humans	human	NNS
cord-001835-0s7ok4uw	2053	17	.	.	.
cord-001835-0s7ok4uw	2054	1	This	this	DT
cord-001835-0s7ok4uw	2054	2	study	study	NN
cord-001835-0s7ok4uw	2054	3	uncovers	uncover	VBZ
cord-001835-0s7ok4uw	2054	4	the	the	DT
cord-001835-0s7ok4uw	2054	5	molecular	molecular	JJ
cord-001835-0s7ok4uw	2054	6	basis	basis	NN
cord-001835-0s7ok4uw	2054	7	for	for	IN
cord-001835-0s7ok4uw	2054	8	an	an	DT
cord-001835-0s7ok4uw	2054	9	important	important	JJ
cord-001835-0s7ok4uw	2054	10	aspect	aspect	NN
cord-001835-0s7ok4uw	2054	11	of	of	IN
cord-001835-0s7ok4uw	2054	12	natural	natural	JJ
cord-001835-0s7ok4uw	2054	13	protein	protein	NN
cord-001835-0s7ok4uw	2054	14	evolution	evolution	NN
cord-001835-0s7ok4uw	2054	15	and	and	CC
cord-001835-0s7ok4uw	2054	16	describes	describe	VBZ
cord-001835-0s7ok4uw	2054	17	a	a	DT
cord-001835-0s7ok4uw	2054	18	novel	novel	JJ
cord-001835-0s7ok4uw	2054	19	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2054	20	for	for	IN
cord-001835-0s7ok4uw	2054	21	adaptation	adaptation	NN
cord-001835-0s7ok4uw	2054	22	in	in	IN
cord-001835-0s7ok4uw	2054	23	response	response	NN
cord-001835-0s7ok4uw	2054	24	to	to	IN
cord-001835-0s7ok4uw	2054	25	environmental	environmental	JJ
cord-001835-0s7ok4uw	2054	26	changes	change	NNS
cord-001835-0s7ok4uw	2054	27	.	.	.
cord-001835-0s7ok4uw	2055	1	A	a	DT
cord-001835-0s7ok4uw	2055	2	Proline	proline	NN
cord-001835-0s7ok4uw	2055	3	-	-	HYPH
cord-001835-0s7ok4uw	2055	4	Tryptophan	tryptophan	NN
cord-001835-0s7ok4uw	2055	5	turn	turn	NN
cord-001835-0s7ok4uw	2055	6	in	in	IN
cord-001835-0s7ok4uw	2055	7	the	the	DT
cord-001835-0s7ok4uw	2055	8	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2055	9	disordered	disordered	JJ
cord-001835-0s7ok4uw	2055	10	domain	domain	NN
cord-001835-0s7ok4uw	2055	11	2	2	CD
cord-001835-0s7ok4uw	2055	12	of	of	IN
cord-001835-0s7ok4uw	2056	1	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2057	1	protein	protein	NN
cord-001835-0s7ok4uw	2057	2	is	be	VBZ
cord-001835-0s7ok4uw	2057	3	essential	essential	JJ
cord-001835-0s7ok4uw	2057	4	for	for	IN
cord-001835-0s7ok4uw	2057	5	Hepatitis	Hepatitis	NNP
cord-001835-0s7ok4uw	2057	6	Hepatitis	Hepatitis	NNP
cord-001835-0s7ok4uw	2057	7	C	C	NNP
cord-001835-0s7ok4uw	2057	8	virus	virus	NN
cord-001835-0s7ok4uw	2057	9	(	(	-LRB-
cord-001835-0s7ok4uw	2057	10	HCV	HCV	NNP
cord-001835-0s7ok4uw	2057	11	)	)	-RRB-
cord-001835-0s7ok4uw	2057	12	nonstructural	nonstructural	JJ
cord-001835-0s7ok4uw	2057	13	protein	protein	NN
cord-001835-0s7ok4uw	2057	14	5A	5a	NN
cord-001835-0s7ok4uw	2057	15	(	(	-LRB-
cord-001835-0s7ok4uw	2057	16	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2057	17	)	)	-RRB-
cord-001835-0s7ok4uw	2057	18	and	and	CC
cord-001835-0s7ok4uw	2057	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2057	20	interaction	interaction	NN
cord-001835-0s7ok4uw	2057	21	with	with	IN
cord-001835-0s7ok4uw	2057	22	the	the	DT
cord-001835-0s7ok4uw	2057	23	human	human	JJ
cord-001835-0s7ok4uw	2057	24	chaperone	chaperone	NN
cord-001835-0s7ok4uw	2057	25	cyclophilin	cyclophilin	NNP
cord-001835-0s7ok4uw	2057	26	A	A	NNP
cord-001835-0s7ok4uw	2057	27	(	(	-LRB-
cord-001835-0s7ok4uw	2057	28	CypA	CypA	NNP
cord-001835-0s7ok4uw	2057	29	)	)	-RRB-
cord-001835-0s7ok4uw	2057	30	,	,	,
cord-001835-0s7ok4uw	2057	31	a	a	DT
cord-001835-0s7ok4uw	2057	32	peptidyl	peptidyl	NNP
cord-001835-0s7ok4uw	2057	33	-	-	HYPH
cord-001835-0s7ok4uw	2057	34	prolyl	prolyl	NNP
cord-001835-0s7ok4uw	2057	35	cis	cis	NNP
cord-001835-0s7ok4uw	2057	36	-	-	HYPH
cord-001835-0s7ok4uw	2057	37	trans	trans	NNP
cord-001835-0s7ok4uw	2057	38	isomerase	isomerase	NN
cord-001835-0s7ok4uw	2057	39	(	(	-LRB-
cord-001835-0s7ok4uw	2057	40	PPIase	PPIase	NNP
cord-001835-0s7ok4uw	2057	41	)	)	-RRB-
cord-001835-0s7ok4uw	2057	42	,	,	,
cord-001835-0s7ok4uw	2057	43	are	be	VBP
cord-001835-0s7ok4uw	2057	44	both	both	DT
cord-001835-0s7ok4uw	2057	45	targets	target	NNS
cord-001835-0s7ok4uw	2057	46	for	for	IN
cord-001835-0s7ok4uw	2057	47	highly	highly	RB
cord-001835-0s7ok4uw	2057	48	potent	potent	JJ
cord-001835-0s7ok4uw	2057	49	and	and	CC
cord-001835-0s7ok4uw	2057	50	promising	promising	JJ
cord-001835-0s7ok4uw	2057	51	antiviral	antiviral	JJ
cord-001835-0s7ok4uw	2057	52	drugs	drug	NNS
cord-001835-0s7ok4uw	2057	53	that	that	WDT
cord-001835-0s7ok4uw	2057	54	are	be	VBP
cord-001835-0s7ok4uw	2057	55	in	in	IN
cord-001835-0s7ok4uw	2057	56	late	late	JJ
cord-001835-0s7ok4uw	2057	57	stage	stage	NN
cord-001835-0s7ok4uw	2057	58	of	of	IN
cord-001835-0s7ok4uw	2057	59	clinical	clinical	JJ
cord-001835-0s7ok4uw	2057	60	development	development	NN
cord-001835-0s7ok4uw	2057	61	[	[	-LRB-
cord-001835-0s7ok4uw	2057	62	1	1	CD
cord-001835-0s7ok4uw	2057	63	,	,	,
cord-001835-0s7ok4uw	2057	64	2	2	CD
cord-001835-0s7ok4uw	2057	65	]	]	-RRB-
cord-001835-0s7ok4uw	2057	66	.	.	.
cord-001835-0s7ok4uw	2058	1	Despite	despite	IN
cord-001835-0s7ok4uw	2058	2	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2058	3	high	high	JJ
cord-001835-0s7ok4uw	2058	4	interest	interest	NN
cord-001835-0s7ok4uw	2058	5	in	in	IN
cord-001835-0s7ok4uw	2058	6	the	the	DT
cord-001835-0s7ok4uw	2058	7	development	development	NN
cord-001835-0s7ok4uw	2058	8	of	of	IN
cord-001835-0s7ok4uw	2058	9	drugs	drug	NNS
cord-001835-0s7ok4uw	2058	10	to	to	TO
cord-001835-0s7ok4uw	2058	11	counteract	counteract	VB
cord-001835-0s7ok4uw	2058	12	the	the	DT
cord-001835-0s7ok4uw	2058	13	worldwide	worldwide	JJ
cord-001835-0s7ok4uw	2058	14	HCV	HCV	NNP
cord-001835-0s7ok4uw	2058	15	burden	burden	NN
cord-001835-0s7ok4uw	2058	16	,	,	,
cord-001835-0s7ok4uw	2058	17	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2058	18	is	be	VBZ
cord-001835-0s7ok4uw	2058	19	still	still	RB
cord-001835-0s7ok4uw	2058	20	an	an	DT
cord-001835-0s7ok4uw	2058	21	enigmatic	enigmatic	JJ
cord-001835-0s7ok4uw	2058	22	multifunctional	multifunctional	JJ
cord-001835-0s7ok4uw	2058	23	protein	protein	NN
cord-001835-0s7ok4uw	2058	24	poorly	poorly	RB
cord-001835-0s7ok4uw	2058	25	characterized	characterize	VBN
cord-001835-0s7ok4uw	2058	26	at	at	IN
cord-001835-0s7ok4uw	2058	27	the	the	DT
cord-001835-0s7ok4uw	2058	28	molecular	molecular	JJ
cord-001835-0s7ok4uw	2058	29	level	level	NN
cord-001835-0s7ok4uw	2058	30	.	.	.
cord-001835-0s7ok4uw	2059	1	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2059	2	is	be	VBZ
cord-001835-0s7ok4uw	2059	3	required	require	VBN
cord-001835-0s7ok4uw	2059	4	for	for	IN
cord-001835-0s7ok4uw	2059	5	HCV	HCV	NNP
cord-001835-0s7ok4uw	2059	6	RNA	RNA	NNP
cord-001835-0s7ok4uw	2059	7	replication	replication	NN
cord-001835-0s7ok4uw	2059	8	and	and	CC
cord-001835-0s7ok4uw	2059	9	is	be	VBZ
cord-001835-0s7ok4uw	2059	10	involved	involve	VBN
cord-001835-0s7ok4uw	2059	11	in	in	IN
cord-001835-0s7ok4uw	2059	12	viral	viral	JJ
cord-001835-0s7ok4uw	2059	13	particles	particle	NNS
cord-001835-0s7ok4uw	2059	14	formation	formation	NN
cord-001835-0s7ok4uw	2059	15	and	and	CC
cord-001835-0s7ok4uw	2059	16	regulation	regulation	NN
cord-001835-0s7ok4uw	2059	17	of	of	IN
cord-001835-0s7ok4uw	2059	18	host	host	NN
cord-001835-0s7ok4uw	2059	19	pathways	pathway	NNS
cord-001835-0s7ok4uw	2059	20	.	.	.
cord-001835-0s7ok4uw	2060	1	Thus	thus	RB
cord-001835-0s7ok4uw	2060	2	far	far	RB
cord-001835-0s7ok4uw	2060	3	,	,	,
cord-001835-0s7ok4uw	2060	4	no	no	DT
cord-001835-0s7ok4uw	2060	5	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	2060	6	activity	activity	NN
cord-001835-0s7ok4uw	2060	7	or	or	CC
cord-001835-0s7ok4uw	2060	8	precise	precise	JJ
cord-001835-0s7ok4uw	2060	9	molecular	molecular	JJ
cord-001835-0s7ok4uw	2060	10	function	function	NN
cord-001835-0s7ok4uw	2060	11	has	have	VBZ
cord-001835-0s7ok4uw	2060	12	been	be	VBN
cord-001835-0s7ok4uw	2060	13	ascribed	ascribe	VBN
cord-001835-0s7ok4uw	2060	14	to	to	IN
cord-001835-0s7ok4uw	2060	15	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2060	16	that	that	WDT
cord-001835-0s7ok4uw	2060	17	is	be	VBZ
cord-001835-0s7ok4uw	2060	18	composed	compose	VBN
cord-001835-0s7ok4uw	2060	19	of	of	IN
cord-001835-0s7ok4uw	2060	20	a	a	DT
cord-001835-0s7ok4uw	2060	21	highly	highly	RB
cord-001835-0s7ok4uw	2060	22	structured	structured	JJ
cord-001835-0s7ok4uw	2060	23	domain	domain	NN
cord-001835-0s7ok4uw	2060	24	1	1	CD
cord-001835-0s7ok4uw	2060	25	(	(	-LRB-
cord-001835-0s7ok4uw	2060	26	-D1	-D1	NFP
cord-001835-0s7ok4uw	2060	27	)	)	-RRB-
cord-001835-0s7ok4uw	2060	28	,	,	,
cord-001835-0s7ok4uw	2060	29	as	as	RB
cord-001835-0s7ok4uw	2060	30	well	well	RB
cord-001835-0s7ok4uw	2060	31	as	as	IN
cord-001835-0s7ok4uw	2060	32	two	two	CD
cord-001835-0s7ok4uw	2060	33	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2060	34	disordered	disordered	JJ
cord-001835-0s7ok4uw	2060	35	domains	domain	NNS
cord-001835-0s7ok4uw	2060	36	2	2	CD
cord-001835-0s7ok4uw	2060	37	(	(	-LRB-
cord-001835-0s7ok4uw	2060	38	-D2	-D2	NNS
cord-001835-0s7ok4uw	2060	39	)	)	-RRB-
cord-001835-0s7ok4uw	2060	40	and	and	CC
cord-001835-0s7ok4uw	2060	41	3	3	LS
cord-001835-0s7ok4uw	2060	42	(	(	-LRB-
cord-001835-0s7ok4uw	2060	43	-D3	-D3	''
cord-001835-0s7ok4uw	2060	44	)	)	-RRB-
cord-001835-0s7ok4uw	2060	45	.	.	.
cord-001835-0s7ok4uw	2061	1	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2061	2	-	-	HYPH
cord-001835-0s7ok4uw	2061	3	D1	d1	NN
cord-001835-0s7ok4uw	2061	4	structure	structure	NN
cord-001835-0s7ok4uw	2061	5	has	have	VBZ
cord-001835-0s7ok4uw	2061	6	been	be	VBN
cord-001835-0s7ok4uw	2061	7	solved	solve	VBN
cord-001835-0s7ok4uw	2061	8	by	by	IN
cord-001835-0s7ok4uw	2061	9	X	x	NN
cord-001835-0s7ok4uw	2061	10	-	-	NN
cord-001835-0s7ok4uw	2061	11	ray	ray	NN
cord-001835-0s7ok4uw	2061	12	crystallography	crystallography	NN
cord-001835-0s7ok4uw	2061	13	and	and	CC
cord-001835-0s7ok4uw	2061	14	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2061	15	-	-	HYPH
cord-001835-0s7ok4uw	2061	16	D2	d2	NN
cord-001835-0s7ok4uw	2061	17	and	and	CC
cord-001835-0s7ok4uw	2062	1	-D3	-D3	:
cord-001835-0s7ok4uw	2062	2	have	have	VBP
cord-001835-0s7ok4uw	2062	3	been	be	VBN
cord-001835-0s7ok4uw	2062	4	characterized	characterize	VBN
cord-001835-0s7ok4uw	2062	5	by	by	IN
cord-001835-0s7ok4uw	2062	6	NMR	NMR	NNP
cord-001835-0s7ok4uw	2062	7	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2062	8	.	.	.
cord-001835-0s7ok4uw	2063	1	These	these	DT
cord-001835-0s7ok4uw	2063	2	two	two	CD
cord-001835-0s7ok4uw	2063	3	last	last	JJ
cord-001835-0s7ok4uw	2063	4	domains	domain	NNS
cord-001835-0s7ok4uw	2063	5	do	do	VBP
cord-001835-0s7ok4uw	2063	6	not	not	RB
cord-001835-0s7ok4uw	2063	7	adopt	adopt	VB
cord-001835-0s7ok4uw	2063	8	a	a	DT
cord-001835-0s7ok4uw	2063	9	stable	stable	JJ
cord-001835-0s7ok4uw	2063	10	3D	3d	JJ
cord-001835-0s7ok4uw	2063	11	structure	structure	NN
cord-001835-0s7ok4uw	2063	12	but	but	CC
cord-001835-0s7ok4uw	2063	13	rather	rather	RB
cord-001835-0s7ok4uw	2063	14	exist	exist	VBP
cord-001835-0s7ok4uw	2063	15	as	as	IN
cord-001835-0s7ok4uw	2063	16	an	an	DT
cord-001835-0s7ok4uw	2063	17	ensemble	ensemble	NN
cord-001835-0s7ok4uw	2063	18	of	of	IN
cord-001835-0s7ok4uw	2063	19	highly	highly	RB
cord-001835-0s7ok4uw	2063	20	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2063	21	conformers	conformer	NNS
cord-001835-0s7ok4uw	2063	22	.	.	.
cord-001835-0s7ok4uw	2064	1	Using	use	VBG
cord-001835-0s7ok4uw	2064	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	2064	3	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2064	4	,	,	,
cord-001835-0s7ok4uw	2064	5	HCV	HCV	NNP
cord-001835-0s7ok4uw	2064	6	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2064	7	-	-	HYPH
cord-001835-0s7ok4uw	2064	8	D2	D2	NNP
cord-001835-0s7ok4uw	2064	9	has	have	VBZ
cord-001835-0s7ok4uw	2064	10	been	be	VBN
cord-001835-0s7ok4uw	2064	11	shown	show	VBN
cord-001835-0s7ok4uw	2064	12	to	to	TO
cord-001835-0s7ok4uw	2064	13	establish	establish	VB
cord-001835-0s7ok4uw	2064	14	a	a	DT
cord-001835-0s7ok4uw	2064	15	direct	direct	JJ
cord-001835-0s7ok4uw	2064	16	interaction	interaction	NN
cord-001835-0s7ok4uw	2064	17	with	with	IN
cord-001835-0s7ok4uw	2064	18	the	the	DT
cord-001835-0s7ok4uw	2064	19	human	human	NN
cord-001835-0s7ok4uw	2064	20	CypA	CypA	NNP
cord-001835-0s7ok4uw	2064	21	and	and	CC
cord-001835-0s7ok4uw	2064	22	to	to	TO
cord-001835-0s7ok4uw	2064	23	be	be	VB
cord-001835-0s7ok4uw	2064	24	a	a	DT
cord-001835-0s7ok4uw	2064	25	substrate	substrate	NN
cord-001835-0s7ok4uw	2064	26	for	for	IN
cord-001835-0s7ok4uw	2064	27	the	the	DT
cord-001835-0s7ok4uw	2064	28	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	2064	29	PPIase	PPIase	NNP
cord-001835-0s7ok4uw	2064	30	activity	activity	NN
cord-001835-0s7ok4uw	2064	31	of	of	IN
cord-001835-0s7ok4uw	2064	32	CypA	CypA	NNP
cord-001835-0s7ok4uw	2064	33	[	[	-LRB-
cord-001835-0s7ok4uw	2064	34	3	3	CD
cord-001835-0s7ok4uw	2064	35	]	]	-RRB-
cord-001835-0s7ok4uw	2064	36	.	.	.
cord-001835-0s7ok4uw	2065	1	The	the	DT
cord-001835-0s7ok4uw	2065	2	CypA	CypA	NNP
cord-001835-0s7ok4uw	2065	3	interaction	interaction	NN
cord-001835-0s7ok4uw	2065	4	site	site	NN
cord-001835-0s7ok4uw	2065	5	in	in	IN
cord-001835-0s7ok4uw	2065	6	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2065	7	-	-	HYPH
cord-001835-0s7ok4uw	2065	8	D2	D2	NNP
cord-001835-0s7ok4uw	2065	9	is	be	VBZ
cord-001835-0s7ok4uw	2065	10	composed	compose	VBN
cord-001835-0s7ok4uw	2065	11	of	of	IN
cord-001835-0s7ok4uw	2065	12	nearly	nearly	RB
cord-001835-0s7ok4uw	2065	13	15	15	CD
cord-001835-0s7ok4uw	2065	14	residues	residue	NNS
cord-001835-0s7ok4uw	2065	15	that	that	WDT
cord-001835-0s7ok4uw	2065	16	correspond	correspond	VBP
cord-001835-0s7ok4uw	2065	17	to	to	IN
cord-001835-0s7ok4uw	2065	18	the	the	DT
cord-001835-0s7ok4uw	2065	19	most	most	RBS
cord-001835-0s7ok4uw	2065	20	conserved	conserve	VBN
cord-001835-0s7ok4uw	2065	21	region	region	NN
cord-001835-0s7ok4uw	2065	22	of	of	IN
cord-001835-0s7ok4uw	2065	23	the	the	DT
cord-001835-0s7ok4uw	2065	24	domain	domain	NN
cord-001835-0s7ok4uw	2065	25	,	,	,
cord-001835-0s7ok4uw	2065	26	with	with	IN
cord-001835-0s7ok4uw	2065	27	3	3	CD
cord-001835-0s7ok4uw	2065	28	Proline	proline	NN
cord-001835-0s7ok4uw	2065	29	residues	residue	NNS
cord-001835-0s7ok4uw	2065	30	being	be	VBG
cord-001835-0s7ok4uw	2065	31	strictly	strictly	RB
cord-001835-0s7ok4uw	2065	32	conserved	conserve	VBN
cord-001835-0s7ok4uw	2065	33	among	among	IN
cord-001835-0s7ok4uw	2065	34	all	all	DT
cord-001835-0s7ok4uw	2065	35	HCV	HCV	NNP
cord-001835-0s7ok4uw	2065	36	genotypes	genotype	NNS
cord-001835-0s7ok4uw	2065	37	.	.	.
cord-001835-0s7ok4uw	2066	1	Whereas	whereas	IN
cord-001835-0s7ok4uw	2066	2	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2066	3	-	-	HYPH
cord-001835-0s7ok4uw	2066	4	D2	D2	NNP
cord-001835-0s7ok4uw	2066	5	is	be	VBZ
cord-001835-0s7ok4uw	2066	6	mainly	mainly	RB
cord-001835-0s7ok4uw	2066	7	disordered	disordered	JJ
cord-001835-0s7ok4uw	2066	8	,	,	,
cord-001835-0s7ok4uw	2066	9	some	some	DT
cord-001835-0s7ok4uw	2066	10	of	of	IN
cord-001835-0s7ok4uw	2066	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2066	12	NMR	NMR	NNP
cord-001835-0s7ok4uw	2066	13	resonances	resonance	NNS
cord-001835-0s7ok4uw	2066	14	,	,	,
cord-001835-0s7ok4uw	2066	15	corresponding	correspond	VBG
cord-001835-0s7ok4uw	2066	16	to	to	IN
cord-001835-0s7ok4uw	2066	17	residues	residue	NNS
cord-001835-0s7ok4uw	2066	18	in	in	IN
cord-001835-0s7ok4uw	2066	19	the	the	DT
cord-001835-0s7ok4uw	2066	20	CypA	CypA	NNP
cord-001835-0s7ok4uw	2066	21	binding	bind	VBG
cord-001835-0s7ok4uw	2066	22	site	site	NN
cord-001835-0s7ok4uw	2066	23	,	,	,
cord-001835-0s7ok4uw	2066	24	display	display	VBP
cord-001835-0s7ok4uw	2066	25	unexpected	unexpected	JJ
cord-001835-0s7ok4uw	2066	26	1H	1h	CD
cord-001835-0s7ok4uw	2066	27	and	and	CC
cord-001835-0s7ok4uw	2066	28	15N	15n	CD
cord-001835-0s7ok4uw	2066	29	NMR	NMR	NNP
cord-001835-0s7ok4uw	2066	30	chemical	chemical	NN
cord-001835-0s7ok4uw	2066	31	shifts	shift	NNS
cord-001835-0s7ok4uw	2066	32	for	for	IN
cord-001835-0s7ok4uw	2066	33	an	an	DT
cord-001835-0s7ok4uw	2066	34	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2066	35	disordered	disordered	JJ
cord-001835-0s7ok4uw	2066	36	domain	domain	NN
cord-001835-0s7ok4uw	2066	37	.	.	.
cord-001835-0s7ok4uw	2067	1	Thus	thus	RB
cord-001835-0s7ok4uw	2067	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2067	3	have	have	VBP
cord-001835-0s7ok4uw	2067	4	further	further	RB
cord-001835-0s7ok4uw	2067	5	characterized	characterize	VBN
cord-001835-0s7ok4uw	2067	6	this	this	DT
cord-001835-0s7ok4uw	2067	7	region	region	NN
cord-001835-0s7ok4uw	2067	8	by	by	IN
cord-001835-0s7ok4uw	2067	9	NMR	NMR	NNP
cord-001835-0s7ok4uw	2067	10	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2067	11	.	.	.
cord-001835-0s7ok4uw	2068	1	A	a	DT
cord-001835-0s7ok4uw	2068	2	short	short	JJ
cord-001835-0s7ok4uw	2068	3	structural	structural	JJ
cord-001835-0s7ok4uw	2068	4	motif	motif	NN
cord-001835-0s7ok4uw	2068	5	in	in	IN
cord-001835-0s7ok4uw	2068	6	the	the	DT
cord-001835-0s7ok4uw	2068	7	disordered	disordered	JJ
cord-001835-0s7ok4uw	2068	8	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2068	9	-	-	HYPH
cord-001835-0s7ok4uw	2068	10	D2	D2	NNP
cord-001835-0s7ok4uw	2068	11	has	have	VBZ
cord-001835-0s7ok4uw	2068	12	been	be	VBN
cord-001835-0s7ok4uw	2068	13	identified	identify	VBN
cord-001835-0s7ok4uw	2068	14	and	and	CC
cord-001835-0s7ok4uw	2068	15	we	-PRON-	PRP
cord-001835-0s7ok4uw	2068	16	solved	solve	VBD
cord-001835-0s7ok4uw	2068	17	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2068	18	NMR	NMR	NNP
cord-001835-0s7ok4uw	2068	19	structure	structure	NN
cord-001835-0s7ok4uw	2068	20	.	.	.
cord-001835-0s7ok4uw	2069	1	In	in	IN
cord-001835-0s7ok4uw	2069	2	a	a	DT
cord-001835-0s7ok4uw	2069	3	cellular	cellular	JJ
cord-001835-0s7ok4uw	2069	4	assay	assay	NN
cord-001835-0s7ok4uw	2069	5	,	,	,
cord-001835-0s7ok4uw	2069	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	2069	7	showed	show	VBD
cord-001835-0s7ok4uw	2069	8	that	that	IN
cord-001835-0s7ok4uw	2069	9	this	this	DT
cord-001835-0s7ok4uw	2069	10	structural	structural	JJ
cord-001835-0s7ok4uw	2069	11	motif	motif	NN
cord-001835-0s7ok4uw	2069	12	,	,	,
cord-001835-0s7ok4uw	2069	13	a	a	DT
cord-001835-0s7ok4uw	2069	14	minimal	minimal	JJ
cord-001835-0s7ok4uw	2069	15	Pro314-Trp316	Pro314-Trp316	NNP
cord-001835-0s7ok4uw	2069	16	turn	turn	NN
cord-001835-0s7ok4uw	2069	17	,	,	,
cord-001835-0s7ok4uw	2069	18	is	be	VBZ
cord-001835-0s7ok4uw	2069	19	essential	essential	JJ
cord-001835-0s7ok4uw	2069	20	for	for	IN
cord-001835-0s7ok4uw	2069	21	HCV	HCV	NNP
cord-001835-0s7ok4uw	2069	22	RNA	RNA	NNP
cord-001835-0s7ok4uw	2069	23	replication	replication	NN
cord-001835-0s7ok4uw	2069	24	.	.	.
cord-001835-0s7ok4uw	2070	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2070	2	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	2070	3	that	that	IN
cord-001835-0s7ok4uw	2070	4	this	this	DT
cord-001835-0s7ok4uw	2070	5	Pro	pro	JJ
cord-001835-0s7ok4uw	2070	6	-	-	JJ
cord-001835-0s7ok4uw	2070	7	Trp	trp	JJ
cord-001835-0s7ok4uw	2070	8	(	(	-LRB-
cord-001835-0s7ok4uw	2070	9	PW	pw	NN
cord-001835-0s7ok4uw	2070	10	)	)	-RRB-
cord-001835-0s7ok4uw	2070	11	turn	turn	NN
cord-001835-0s7ok4uw	2070	12	is	be	VBZ
cord-001835-0s7ok4uw	2070	13	required	require	VBN
cord-001835-0s7ok4uw	2070	14	for	for	IN
cord-001835-0s7ok4uw	2070	15	proper	proper	JJ
cord-001835-0s7ok4uw	2070	16	interaction	interaction	NN
cord-001835-0s7ok4uw	2070	17	with	with	IN
cord-001835-0s7ok4uw	2070	18	the	the	DT
cord-001835-0s7ok4uw	2070	19	host	host	NN
cord-001835-0s7ok4uw	2070	20	CypA	CypA	NNP
cord-001835-0s7ok4uw	2070	21	and	and	CC
cord-001835-0s7ok4uw	2070	22	influenced	influence	VBD
cord-001835-0s7ok4uw	2070	23	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2070	24	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	2070	25	PPIase	PPIase	NNP
cord-001835-0s7ok4uw	2070	26	activity	activity	NN
cord-001835-0s7ok4uw	2070	27	on	on	IN
cord-001835-0s7ok4uw	2070	28	residue	residue	NN
cord-001835-0s7ok4uw	2070	29	P314	P314	NNP
cord-001835-0s7ok4uw	2070	30	of	of	IN
cord-001835-0s7ok4uw	2070	31	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2070	32	-	-	HYPH
cord-001835-0s7ok4uw	2070	33	D2	D2	NNP
cord-001835-0s7ok4uw	2070	34	.	.	.
cord-001835-0s7ok4uw	2071	1	This	this	DT
cord-001835-0s7ok4uw	2071	2	work	work	NN
cord-001835-0s7ok4uw	2071	3	provides	provide	VBZ
cord-001835-0s7ok4uw	2071	4	a	a	DT
cord-001835-0s7ok4uw	2071	5	molecular	molecular	JJ
cord-001835-0s7ok4uw	2071	6	basis	basis	NN
cord-001835-0s7ok4uw	2071	7	for	for	IN
cord-001835-0s7ok4uw	2071	8	further	further	JJ
cord-001835-0s7ok4uw	2071	9	understanding	understanding	NN
cord-001835-0s7ok4uw	2071	10	of	of	IN
cord-001835-0s7ok4uw	2071	11	the	the	DT
cord-001835-0s7ok4uw	2071	12	function	function	NN
cord-001835-0s7ok4uw	2071	13	of	of	IN
cord-001835-0s7ok4uw	2071	14	the	the	DT
cord-001835-0s7ok4uw	2071	15	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2071	16	disordered	disordered	JJ
cord-001835-0s7ok4uw	2071	17	domain	domain	NN
cord-001835-0s7ok4uw	2071	18	2	2	CD
cord-001835-0s7ok4uw	2071	19	of	of	IN
cord-001835-0s7ok4uw	2071	20	HCV	HCV	NNP
cord-001835-0s7ok4uw	2071	21	NS5A	NS5A	NNP
cord-001835-0s7ok4uw	2071	22	protein	protein	NN
cord-001835-0s7ok4uw	2071	23	.	.	.
cord-001835-0s7ok4uw	2072	1	In	in	IN
cord-001835-0s7ok4uw	2072	2	addition	addition	NN
cord-001835-0s7ok4uw	2072	3	,	,	,
cord-001835-0s7ok4uw	2072	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2072	5	work	work	NN
cord-001835-0s7ok4uw	2072	6	highlights	highlight	VBZ
cord-001835-0s7ok4uw	2072	7	how	how	WRB
cord-001835-0s7ok4uw	2072	8	very	very	RB
cord-001835-0s7ok4uw	2072	9	small	small	JJ
cord-001835-0s7ok4uw	2072	10	structural	structural	JJ
cord-001835-0s7ok4uw	2072	11	motifs	motif	NNS
cord-001835-0s7ok4uw	2072	12	present	present	JJ
cord-001835-0s7ok4uw	2072	13	in	in	IN
cord-001835-0s7ok4uw	2072	14	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2072	15	disordered	disordered	JJ
cord-001835-0s7ok4uw	2072	16	proteins	protein	NNS
cord-001835-0s7ok4uw	2072	17	can	can	MD
cord-001835-0s7ok4uw	2072	18	exert	exert	VB
cord-001835-0s7ok4uw	2072	19	a	a	DT
cord-001835-0s7ok4uw	2072	20	specific	specific	JJ
cord-001835-0s7ok4uw	2072	21	function	function	NN
cord-001835-0s7ok4uw	2072	22	.	.	.
cord-001835-0s7ok4uw	2073	1	[	[	-LRB-
cord-001835-0s7ok4uw	2073	2	1	1	CD
cord-001835-0s7ok4uw	2073	3	]	]	-RRB-
cord-001835-0s7ok4uw	2073	4	[	[	-LRB-
cord-001835-0s7ok4uw	2073	5	2	2	CD
cord-001835-0s7ok4uw	2073	6	]	]	-RRB-
cord-001835-0s7ok4uw	2073	7	.	.	.
cord-001835-0s7ok4uw	2074	1	This	this	DT
cord-001835-0s7ok4uw	2074	2	27-residue	27-residue	CD
cord-001835-0s7ok4uw	2074	3	peptide	peptide	NN
cord-001835-0s7ok4uw	2074	4	also	also	RB
cord-001835-0s7ok4uw	2074	5	shows	show	VBZ
cord-001835-0s7ok4uw	2074	6	toxicity	toxicity	NN
cord-001835-0s7ok4uw	2074	7	towards	towards	IN
cord-001835-0s7ok4uw	2074	8	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	2074	9	cells	cell	NNS
cord-001835-0s7ok4uw	2074	10	but	but	CC
cord-001835-0s7ok4uw	2074	11	at	at	IN
cord-001835-0s7ok4uw	2074	12	higher	high	JJR
cord-001835-0s7ok4uw	2074	13	concentrations	concentration	NNS
cord-001835-0s7ok4uw	2074	14	,	,	,
cord-001835-0s7ok4uw	2074	15	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2074	16	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2074	17	possible	possible	JJ
cord-001835-0s7ok4uw	2074	18	usefulness	usefulness	NN
cord-001835-0s7ok4uw	2074	19	as	as	IN
cord-001835-0s7ok4uw	2074	20	a	a	DT
cord-001835-0s7ok4uw	2074	21	treatment	treatment	NN
cord-001835-0s7ok4uw	2074	22	for	for	IN
cord-001835-0s7ok4uw	2074	23	trypanosomiasis	trypanosomiasis	NN
cord-001835-0s7ok4uw	2074	24	.	.	.
cord-001835-0s7ok4uw	2075	1	Here	here	RB
cord-001835-0s7ok4uw	2075	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2075	3	present	present	VBP
cord-001835-0s7ok4uw	2075	4	the	the	DT
cord-001835-0s7ok4uw	2075	5	peptide	peptide	NN
cord-001835-0s7ok4uw	2075	6	's	's	POS
cord-001835-0s7ok4uw	2075	7	relative	relative	JJ
cord-001835-0s7ok4uw	2075	8	cytotoxicity	cytotoxicity	NN
cord-001835-0s7ok4uw	2075	9	for	for	IN
cord-001835-0s7ok4uw	2075	10	bloodstream	bloodstream	NN
cord-001835-0s7ok4uw	2075	11	and	and	CC
cord-001835-0s7ok4uw	2075	12	procyclic	procyclic	JJ
cord-001835-0s7ok4uw	2075	13	forms	form	NNS
cord-001835-0s7ok4uw	2075	14	of	of	IN
cord-001835-0s7ok4uw	2075	15	T.	T.	NNP
cord-001835-0s7ok4uw	2075	16	brucei	brucei	NN
cord-001835-0s7ok4uw	2075	17	and	and	CC
cord-001835-0s7ok4uw	2075	18	for	for	IN
cord-001835-0s7ok4uw	2075	19	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	2075	20	cells	cell	NNS
cord-001835-0s7ok4uw	2075	21	,	,	,
cord-001835-0s7ok4uw	2075	22	the	the	DT
cord-001835-0s7ok4uw	2075	23	fate	fate	NN
cord-001835-0s7ok4uw	2075	24	of	of	IN
cord-001835-0s7ok4uw	2075	25	the	the	DT
cord-001835-0s7ok4uw	2075	26	peptide	peptide	NN
cord-001835-0s7ok4uw	2075	27	in	in	IN
cord-001835-0s7ok4uw	2075	28	T.	T.	NNP
cord-001835-0s7ok4uw	2075	29	brucei	brucei	NNP
cord-001835-0s7ok4uw	2075	30	using	use	VBG
cord-001835-0s7ok4uw	2075	31	fluorescently	fluorescently	RB
cord-001835-0s7ok4uw	2075	32	-	-	HYPH
cord-001835-0s7ok4uw	2075	33	labelled	label	VBN
cord-001835-0s7ok4uw	2075	34	Bt-6	Bt-6	NNP
cord-001835-0s7ok4uw	2075	35	,	,	,
cord-001835-0s7ok4uw	2075	36	and	and	CC
cord-001835-0s7ok4uw	2075	37	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2075	38	three	three	CD
cord-001835-0s7ok4uw	2075	39	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	2075	40	structure	structure	NN
cord-001835-0s7ok4uw	2075	41	using	use	VBG
cord-001835-0s7ok4uw	2075	42	NMR	NMR	NNP
cord-001835-0s7ok4uw	2075	43	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2075	44	.	.	.
cord-001835-0s7ok4uw	2076	1	Minimum	minimum	JJ
cord-001835-0s7ok4uw	2076	2	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	2076	3	assays	assay	NNS
cord-001835-0s7ok4uw	2076	4	confirmed	confirm	VBD
cord-001835-0s7ok4uw	2076	5	the	the	DT
cord-001835-0s7ok4uw	2076	6	peptide	peptide	NN
cord-001835-0s7ok4uw	2076	7	's	's	POS
cord-001835-0s7ok4uw	2076	8	selective	selective	JJ
cord-001835-0s7ok4uw	2076	9	toxicity	toxicity	NN
cord-001835-0s7ok4uw	2076	10	towards	towards	IN
cord-001835-0s7ok4uw	2076	11	both	both	CC
cord-001835-0s7ok4uw	2076	12	bloodstream	bloodstream	NN
cord-001835-0s7ok4uw	2076	13	and	and	CC
cord-001835-0s7ok4uw	2076	14	procyclic	procyclic	JJ
cord-001835-0s7ok4uw	2076	15	forms	form	NNS
cord-001835-0s7ok4uw	2076	16	of	of	IN
cord-001835-0s7ok4uw	2076	17	T.	T.	NNP
cord-001835-0s7ok4uw	2076	18	brucei	brucei	NNP
cord-001835-0s7ok4uw	2076	19	,	,	,
cord-001835-0s7ok4uw	2076	20	demonstrating	demonstrate	VBG
cord-001835-0s7ok4uw	2076	21	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2076	22	potential	potential	NN
cord-001835-0s7ok4uw	2076	23	to	to	TO
cord-001835-0s7ok4uw	2076	24	serve	serve	VB
cord-001835-0s7ok4uw	2076	25	as	as	IN
cord-001835-0s7ok4uw	2076	26	a	a	DT
cord-001835-0s7ok4uw	2076	27	starting	starting	NN
cord-001835-0s7ok4uw	2076	28	point	point	NN
cord-001835-0s7ok4uw	2076	29	for	for	IN
cord-001835-0s7ok4uw	2076	30	a	a	DT
cord-001835-0s7ok4uw	2076	31	trypanocidal	trypanocidal	JJ
cord-001835-0s7ok4uw	2076	32	drug	drug	NN
cord-001835-0s7ok4uw	2076	33	.	.	.
cord-001835-0s7ok4uw	2077	1	Fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2077	2	spectrophotometric	spectrophotometric	JJ
cord-001835-0s7ok4uw	2077	3	experiments	experiment	NNS
cord-001835-0s7ok4uw	2077	4	,	,	,
cord-001835-0s7ok4uw	2077	5	carried	carry	VBD
cord-001835-0s7ok4uw	2077	6	out	out	RP
cord-001835-0s7ok4uw	2077	7	using	use	VBG
cord-001835-0s7ok4uw	2077	8	fluorescein	fluorescein	NN
cord-001835-0s7ok4uw	2077	9	labelled	label	VBN
cord-001835-0s7ok4uw	2077	10	Bt-6	Bt-6	NNP
cord-001835-0s7ok4uw	2077	11	,	,	,
cord-001835-0s7ok4uw	2077	12	show	show	VB
cord-001835-0s7ok4uw	2077	13	that	that	IN
cord-001835-0s7ok4uw	2077	14	the	the	DT
cord-001835-0s7ok4uw	2077	15	peptide	peptide	NN
cord-001835-0s7ok4uw	2077	16	is	be	VBZ
cord-001835-0s7ok4uw	2077	17	released	release	VBN
cord-001835-0s7ok4uw	2077	18	from	from	IN
cord-001835-0s7ok4uw	2077	19	the	the	DT
cord-001835-0s7ok4uw	2077	20	external	external	JJ
cord-001835-0s7ok4uw	2077	21	surface	surface	NN
cord-001835-0s7ok4uw	2077	22	of	of	IN
cord-001835-0s7ok4uw	2077	23	the	the	DT
cord-001835-0s7ok4uw	2077	24	parasite	parasite	NN
cord-001835-0s7ok4uw	2077	25	into	into	IN
cord-001835-0s7ok4uw	2077	26	the	the	DT
cord-001835-0s7ok4uw	2077	27	suspending	suspend	VBG
cord-001835-0s7ok4uw	2077	28	medium	medium	NN
cord-001835-0s7ok4uw	2077	29	under	under	IN
cord-001835-0s7ok4uw	2077	30	de	de	JJ
cord-001835-0s7ok4uw	2077	31	-	-	JJ
cord-001835-0s7ok4uw	2077	32	energized	energize	VBN
cord-001835-0s7ok4uw	2077	33	conditions	condition	NNS
cord-001835-0s7ok4uw	2077	34	but	but	CC
cord-001835-0s7ok4uw	2077	35	retained	retain	VBN
cord-001835-0s7ok4uw	2077	36	in	in	IN
cord-001835-0s7ok4uw	2077	37	energized	energized	JJ
cord-001835-0s7ok4uw	2077	38	cells	cell	NNS
cord-001835-0s7ok4uw	2077	39	.	.	.
cord-001835-0s7ok4uw	2078	1	Heteronuclear	Heteronuclear	NNP
cord-001835-0s7ok4uw	2078	2	and	and	CC
cord-001835-0s7ok4uw	2078	3	homonuclear	homonuclear	VB
cord-001835-0s7ok4uw	2078	4	biomolecular	biomolecular	JJ
cord-001835-0s7ok4uw	2078	5	NMR	NMR	NNP
cord-001835-0s7ok4uw	2078	6	experiments	experiment	NNS
cord-001835-0s7ok4uw	2078	7	(	(	-LRB-
cord-001835-0s7ok4uw	2078	8	TOCSY	TOCSY	NNP
cord-001835-0s7ok4uw	2078	9	,	,	,
cord-001835-0s7ok4uw	2078	10	NOESY	NOESY	NNP
cord-001835-0s7ok4uw	2078	11	,	,	,
cord-001835-0s7ok4uw	2078	12	1H-13C	1h-13c	CD
cord-001835-0s7ok4uw	2078	13	-	-	HYPH
cord-001835-0s7ok4uw	2078	14	HSQC,1H-15N	HSQC,1H-15N	NNP
cord-001835-0s7ok4uw	2078	15	-	-	HYPH
cord-001835-0s7ok4uw	2078	16	HSQC	HSQC	NNP
cord-001835-0s7ok4uw	2078	17	,	,	,
cord-001835-0s7ok4uw	2078	18	etc	etc	FW
cord-001835-0s7ok4uw	2078	19	)	)	-RRB-
cord-001835-0s7ok4uw	2079	1	folowed	folowe	VBN
cord-001835-0s7ok4uw	2079	2	by	by	IN
cord-001835-0s7ok4uw	2079	3	structural	structural	JJ
cord-001835-0s7ok4uw	2079	4	calculations	calculation	NNS
cord-001835-0s7ok4uw	2079	5	(	(	-LRB-
cord-001835-0s7ok4uw	2079	6	chemical	chemical	JJ
cord-001835-0s7ok4uw	2079	7	-	-	HYPH
cord-001835-0s7ok4uw	2079	8	shift	shift	NN
cord-001835-0s7ok4uw	2079	9	based	base	VBN
cord-001835-0s7ok4uw	2079	10	as	as	RB
cord-001835-0s7ok4uw	2079	11	well	well	RB
cord-001835-0s7ok4uw	2079	12	as	as	IN
cord-001835-0s7ok4uw	2079	13	simulated	simulated	JJ
cord-001835-0s7ok4uw	2079	14	annealing	annealing	NN
cord-001835-0s7ok4uw	2079	15	techniques	technique	NNS
cord-001835-0s7ok4uw	2079	16	)	)	-RRB-
cord-001835-0s7ok4uw	2079	17	in	in	IN
cord-001835-0s7ok4uw	2079	18	the	the	DT
cord-001835-0s7ok4uw	2079	19	free	free	JJ
cord-001835-0s7ok4uw	2079	20	state	state	NN
cord-001835-0s7ok4uw	2079	21	indicate	indicate	VBP
cord-001835-0s7ok4uw	2079	22	that	that	IN
cord-001835-0s7ok4uw	2079	23	this	this	DT
cord-001835-0s7ok4uw	2079	24	peptide	peptide	NN
cord-001835-0s7ok4uw	2079	25	is	be	VBZ
cord-001835-0s7ok4uw	2079	26	mostly	mostly	RB
cord-001835-0s7ok4uw	2079	27	unstructured	unstructured	JJ
cord-001835-0s7ok4uw	2079	28	in	in	IN
cord-001835-0s7ok4uw	2079	29	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	2079	30	solution	solution	NN
cord-001835-0s7ok4uw	2079	31	,	,	,
cord-001835-0s7ok4uw	2079	32	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2079	33	that	that	IN
cord-001835-0s7ok4uw	2079	34	there	there	EX
cord-001835-0s7ok4uw	2079	35	is	be	VBZ
cord-001835-0s7ok4uw	2079	36	a	a	DT
cord-001835-0s7ok4uw	2079	37	major	major	JJ
cord-001835-0s7ok4uw	2079	38	conformational	conformational	JJ
cord-001835-0s7ok4uw	2079	39	change	change	NN
cord-001835-0s7ok4uw	2079	40	upon	upon	IN
cord-001835-0s7ok4uw	2079	41	binding	bind	VBG
cord-001835-0s7ok4uw	2079	42	to	to	IN
cord-001835-0s7ok4uw	2079	43	T.	T.	NNP
cord-001835-0s7ok4uw	2079	44	brucei	brucei	NN
cord-001835-0s7ok4uw	2079	45	that	that	WDT
cord-001835-0s7ok4uw	2079	46	is	be	VBZ
cord-001835-0s7ok4uw	2079	47	required	require	VBN
cord-001835-0s7ok4uw	2079	48	for	for	IN
cord-001835-0s7ok4uw	2079	49	uptake	uptake	NN
cord-001835-0s7ok4uw	2079	50	.	.	.
cord-001835-0s7ok4uw	2080	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2080	2	suggest	suggest	VBP
cord-001835-0s7ok4uw	2080	3	that	that	IN
cord-001835-0s7ok4uw	2080	4	the	the	DT
cord-001835-0s7ok4uw	2080	5	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	2080	6	pressure	pressure	NN
cord-001835-0s7ok4uw	2080	7	that	that	WDT
cord-001835-0s7ok4uw	2080	8	selected	select	VBD
cord-001835-0s7ok4uw	2080	9	for	for	IN
cord-001835-0s7ok4uw	2080	10	the	the	DT
cord-001835-0s7ok4uw	2080	11	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2080	12	disordered	disordered	JJ
cord-001835-0s7ok4uw	2080	13	structure	structure	NN
cord-001835-0s7ok4uw	2080	14	of	of	IN
cord-001835-0s7ok4uw	2080	15	this	this	DT
cord-001835-0s7ok4uw	2080	16	peptide	peptide	NN
cord-001835-0s7ok4uw	2080	17	was	be	VBD
cord-001835-0s7ok4uw	2080	18	the	the	DT
cord-001835-0s7ok4uw	2080	19	advantage	advantage	NN
cord-001835-0s7ok4uw	2080	20	it	-PRON-	PRP
cord-001835-0s7ok4uw	2080	21	conferred	confer	VBD
cord-001835-0s7ok4uw	2080	22	upon	upon	IN
cord-001835-0s7ok4uw	2080	23	the	the	DT
cord-001835-0s7ok4uw	2080	24	host	host	NN
cord-001835-0s7ok4uw	2080	25	to	to	TO
cord-001835-0s7ok4uw	2080	26	bind	bind	VB
cord-001835-0s7ok4uw	2080	27	to	to	IN
cord-001835-0s7ok4uw	2080	28	many	many	JJ
cord-001835-0s7ok4uw	2080	29	different	different	JJ
cord-001835-0s7ok4uw	2080	30	surface	surface	NN
cord-001835-0s7ok4uw	2080	31	structures	structure	NNS
cord-001835-0s7ok4uw	2080	32	throughout	throughout	IN
cord-001835-0s7ok4uw	2080	33	the	the	DT
cord-001835-0s7ok4uw	2080	34	microbiological	microbiological	JJ
cord-001835-0s7ok4uw	2080	35	world	world	NN
cord-001835-0s7ok4uw	2080	36	.	.	.
cord-001835-0s7ok4uw	2081	1	Physikalische	Physikalische	NNP
cord-001835-0s7ok4uw	2081	2	Biologie	Biologie	NNP
cord-001835-0s7ok4uw	2081	3	,	,	,
cord-001835-0s7ok4uw	2081	4	Heinrich	Heinrich	NNP
cord-001835-0s7ok4uw	2081	5	Heine	Heine	NNP
cord-001835-0s7ok4uw	2081	6	University	University	NNP
cord-001835-0s7ok4uw	2081	7	,	,	,
cord-001835-0s7ok4uw	2081	8	2	2	CD
cord-001835-0s7ok4uw	2081	9	Structural	Structural	NNP
cord-001835-0s7ok4uw	2081	10	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	2081	11	(	(	-LRB-
cord-001835-0s7ok4uw	2081	12	ICS-6	ICS-6	NNP
cord-001835-0s7ok4uw	2081	13	)	)	-RRB-
cord-001835-0s7ok4uw	2081	14	,	,	,
cord-001835-0s7ok4uw	2081	15	Research	Research	NNP
cord-001835-0s7ok4uw	2081	16	Centre	Centre	NNP
cord-001835-0s7ok4uw	2081	17	J€	J€	NNP
cord-001835-0s7ok4uw	2081	18	ulich	ulich	NN
cord-001835-0s7ok4uw	2081	19	,	,	,
cord-001835-0s7ok4uw	2081	20	3	3	CD
cord-001835-0s7ok4uw	2081	21	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	2081	22	and	and	CC
cord-001835-0s7ok4uw	2081	23	Biotechnology	Biotechnology	NNP
cord-001835-0s7ok4uw	2081	24	,	,	,
cord-001835-0s7ok4uw	2081	25	Swedish	Swedish	NNP
cord-001835-0s7ok4uw	2081	26	University	University	NNP
cord-001835-0s7ok4uw	2081	27	of	of	IN
cord-001835-0s7ok4uw	2081	28	Agricultural	Agricultural	NNP
cord-001835-0s7ok4uw	2081	29	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	2081	30	(	(	-LRB-
cord-001835-0s7ok4uw	2081	31	SLU	SLU	NNP
cord-001835-0s7ok4uw	2081	32	)	)	-RRB-
cord-001835-0s7ok4uw	2082	1	The	the	DT
cord-001835-0s7ok4uw	2082	2	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	2082	3	and	and	CC
cord-001835-0s7ok4uw	2082	4	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2082	5	formation	formation	NN
cord-001835-0s7ok4uw	2082	6	of	of	IN
cord-001835-0s7ok4uw	2082	7	proteins	protein	NNS
cord-001835-0s7ok4uw	2082	8	featuring	feature	VBG
cord-001835-0s7ok4uw	2082	9	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2082	10	disordered	disordered	JJ
cord-001835-0s7ok4uw	2082	11	regions	region	NNS
cord-001835-0s7ok4uw	2082	12	is	be	VBZ
cord-001835-0s7ok4uw	2082	13	a	a	DT
cord-001835-0s7ok4uw	2082	14	pathological	pathological	JJ
cord-001835-0s7ok4uw	2082	15	hallmark	hallmark	NN
cord-001835-0s7ok4uw	2082	16	of	of	IN
cord-001835-0s7ok4uw	2082	17	several	several	JJ
cord-001835-0s7ok4uw	2082	18	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	2082	19	diseases	disease	NNS
cord-001835-0s7ok4uw	2082	20	,	,	,
cord-001835-0s7ok4uw	2082	21	including	include	VBG
cord-001835-0s7ok4uw	2082	22	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	2082	23	's	's	POS
cord-001835-0s7ok4uw	2082	24	disease	disease	NN
cord-001835-0s7ok4uw	2082	25	and	and	CC
cord-001835-0s7ok4uw	2082	26	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	2082	27	's	's	POS
cord-001835-0s7ok4uw	2082	28	disease	disease	NN
cord-001835-0s7ok4uw	2082	29	.	.	.
cord-001835-0s7ok4uw	2083	1	Engineered	engineer	VBN
cord-001835-0s7ok4uw	2083	2	binding	binding	NN
cord-001835-0s7ok4uw	2083	3	proteins	protein	NNS
cord-001835-0s7ok4uw	2083	4	targeting	target	VBG
cord-001835-0s7ok4uw	2083	5	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	2083	6	proteins	protein	NNS
cord-001835-0s7ok4uw	2083	7	aid	aid	VBP
cord-001835-0s7ok4uw	2083	8	in	in	IN
cord-001835-0s7ok4uw	2083	9	the	the	DT
cord-001835-0s7ok4uw	2083	10	elucidation	elucidation	NN
cord-001835-0s7ok4uw	2083	11	of	of	IN
cord-001835-0s7ok4uw	2083	12	the	the	DT
cord-001835-0s7ok4uw	2083	13	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2083	14	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2083	15	and	and	CC
cord-001835-0s7ok4uw	2083	16	suggest	suggest	VBP
cord-001835-0s7ok4uw	2083	17	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	2083	18	strategies	strategy	NNS
cord-001835-0s7ok4uw	2083	19	.	.	.
cord-001835-0s7ok4uw	2084	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2084	2	have	have	VBP
cord-001835-0s7ok4uw	2084	3	constructed	construct	VBN
cord-001835-0s7ok4uw	2084	4	phage	phage	NN
cord-001835-0s7ok4uw	2084	5	display	display	NN
cord-001835-0s7ok4uw	2084	6	libraries	library	NNS
cord-001835-0s7ok4uw	2084	7	enriched	enrich	VBN
cord-001835-0s7ok4uw	2084	8	in	in	IN
cord-001835-0s7ok4uw	2084	9	binders	binder	NNS
cord-001835-0s7ok4uw	2084	10	to	to	IN
cord-001835-0s7ok4uw	2084	11	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	2084	12	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2084	13	disordered	disordered	JJ
cord-001835-0s7ok4uw	2084	14	proteins	protein	NNS
cord-001835-0s7ok4uw	2084	15	,	,	,
cord-001835-0s7ok4uw	2084	16	using	use	VBG
cord-001835-0s7ok4uw	2084	17	ZAb3	ZAb3	NNP
cord-001835-0s7ok4uw	2084	18	,	,	,
cord-001835-0s7ok4uw	2084	19	a	a	DT
cord-001835-0s7ok4uw	2084	20	protein	protein	NN
cord-001835-0s7ok4uw	2084	21	with	with	IN
cord-001835-0s7ok4uw	2084	22	high	high	JJ
cord-001835-0s7ok4uw	2084	23	affinity	affinity	NN
cord-001835-0s7ok4uw	2084	24	for	for	IN
cord-001835-0s7ok4uw	2084	25	the	the	DT
cord-001835-0s7ok4uw	2084	26	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2084	27	-	-	HYPH
cord-001835-0s7ok4uw	2084	28	beta	beta	NN
cord-001835-0s7ok4uw	2084	29	peptide	peptide	NN
cord-001835-0s7ok4uw	2084	30	,	,	,
cord-001835-0s7ok4uw	2084	31	as	as	IN
cord-001835-0s7ok4uw	2084	32	a	a	DT
cord-001835-0s7ok4uw	2084	33	scaffold	scaffold	NN
cord-001835-0s7ok4uw	2084	34	.	.	.
cord-001835-0s7ok4uw	2085	1	Binding	bind	VBG
cord-001835-0s7ok4uw	2085	2	proteins	protein	NNS
cord-001835-0s7ok4uw	2085	3	selected	select	VBN
cord-001835-0s7ok4uw	2085	4	from	from	IN
cord-001835-0s7ok4uw	2085	5	these	these	DT
cord-001835-0s7ok4uw	2085	6	libraries	library	NNS
cord-001835-0s7ok4uw	2085	7	are	be	VBP
cord-001835-0s7ok4uw	2085	8	termed	term	VBN
cord-001835-0s7ok4uw	2085	9	beta	beta	NN
cord-001835-0s7ok4uw	2085	10	-	-	HYPH
cord-001835-0s7ok4uw	2085	11	wrapins	wrapin	NNS
cord-001835-0s7ok4uw	2085	12	(	(	-LRB-
cord-001835-0s7ok4uw	2085	13	beta	beta	JJ
cord-001835-0s7ok4uw	2085	14	-	-	HYPH
cord-001835-0s7ok4uw	2085	15	wrap	wrap	NN
cord-001835-0s7ok4uw	2085	16	proteins	protein	NNS
cord-001835-0s7ok4uw	2085	17	)	)	-RRB-
cord-001835-0s7ok4uw	2085	18	.	.	.
cord-001835-0s7ok4uw	2086	1	The	the	DT
cord-001835-0s7ok4uw	2086	2	beta	beta	NN
cord-001835-0s7ok4uw	2086	3	-	-	HYPH
cord-001835-0s7ok4uw	2086	4	wrapins	wrapin	NNS
cord-001835-0s7ok4uw	2086	5	AS69	AS69	NNP
cord-001835-0s7ok4uw	2086	6	and	and	CC
cord-001835-0s7ok4uw	2086	7	HI18	HI18	NNP
cord-001835-0s7ok4uw	2086	8	exhibit	exhibit	VB
cord-001835-0s7ok4uw	2086	9	nanomolar	nanomolar	JJ
cord-001835-0s7ok4uw	2086	10	affinity	affinity	NN
cord-001835-0s7ok4uw	2086	11	for	for	IN
cord-001835-0s7ok4uw	2086	12	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	2086	13	alpha	alpha	NN
cord-001835-0s7ok4uw	2086	14	-	-	HYPH
cord-001835-0s7ok4uw	2086	15	synuclein	synuclein	NNP
cord-001835-0s7ok4uw	2086	16	or	or	CC
cord-001835-0s7ok4uw	2086	17	islet	islet	NN
cord-001835-0s7ok4uw	2086	18	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2086	19	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	2086	20	,	,	,
cord-001835-0s7ok4uw	2086	21	respectively	respectively	RB
cord-001835-0s7ok4uw	2086	22	.	.	.
cord-001835-0s7ok4uw	2087	1	AS69	AS69	NNP
cord-001835-0s7ok4uw	2087	2	and	and	CC
cord-001835-0s7ok4uw	2087	3	HI18	HI18	NNP
cord-001835-0s7ok4uw	2087	4	potently	potently	RB
cord-001835-0s7ok4uw	2087	5	inhibit	inhibit	VB
cord-001835-0s7ok4uw	2087	6	in	in	IN
cord-001835-0s7ok4uw	2087	7	vitro	vitro	FW
cord-001835-0s7ok4uw	2087	8	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2087	9	formation	formation	NN
cord-001835-0s7ok4uw	2087	10	and	and	CC
cord-001835-0s7ok4uw	2087	11	toxicity	toxicity	NN
cord-001835-0s7ok4uw	2087	12	at	at	IN
cord-001835-0s7ok4uw	2087	13	substoichiometric	substoichiometric	JJ
cord-001835-0s7ok4uw	2087	14	concentration	concentration	NN
cord-001835-0s7ok4uw	2087	15	ratios	ratio	NNS
cord-001835-0s7ok4uw	2087	16	,	,	,
cord-001835-0s7ok4uw	2087	17	indicating	indicate	VBG
cord-001835-0s7ok4uw	2087	18	that	that	IN
cord-001835-0s7ok4uw	2087	19	they	-PRON-	PRP
cord-001835-0s7ok4uw	2087	20	interfere	interfere	VBP
cord-001835-0s7ok4uw	2087	21	with	with	IN
cord-001835-0s7ok4uw	2087	22	the	the	DT
cord-001835-0s7ok4uw	2087	23	nucleation	nucleation	NN
cord-001835-0s7ok4uw	2087	24	and/or	and/or	CC
cord-001835-0s7ok4uw	2087	25	elongation	elongation	NN
cord-001835-0s7ok4uw	2087	26	of	of	IN
cord-001835-0s7ok4uw	2087	27	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2087	28	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2087	29	.	.	.
cord-001835-0s7ok4uw	2088	1	The	the	DT
cord-001835-0s7ok4uw	2088	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	2088	3	structures	structure	NNS
cord-001835-0s7ok4uw	2088	4	of	of	IN
cord-001835-0s7ok4uw	2088	5	the	the	DT
cord-001835-0s7ok4uw	2088	6	betawrapin	betawrapin	NNP
cord-001835-0s7ok4uw	2088	7	:	:	:
cord-001835-0s7ok4uw	2089	1	target	target	NN
cord-001835-0s7ok4uw	2089	2	complexes	complex	NNS
cord-001835-0s7ok4uw	2089	3	reveal	reveal	VBP
cord-001835-0s7ok4uw	2089	4	beta	beta	NN
cord-001835-0s7ok4uw	2089	5	-	-	HYPH
cord-001835-0s7ok4uw	2089	6	hairpin	hairpin	JJ
cord-001835-0s7ok4uw	2089	7	motifs	motif	NNS
cord-001835-0s7ok4uw	2089	8	in	in	IN
cord-001835-0s7ok4uw	2089	9	alpha	alpha	NN
cord-001835-0s7ok4uw	2089	10	-	-	HYPH
cord-001835-0s7ok4uw	2089	11	synuclein	synuclein	NN
cord-001835-0s7ok4uw	2089	12	and	and	CC
cord-001835-0s7ok4uw	2089	13	islet	islet	NN
cord-001835-0s7ok4uw	2089	14	amyloid	amyloid	NNP
cord-001835-0s7ok4uw	2089	15	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	2089	16	which	which	WDT
cord-001835-0s7ok4uw	2089	17	are	be	VBP
cord-001835-0s7ok4uw	2089	18	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	2089	19	by	by	IN
cord-001835-0s7ok4uw	2089	20	coupled	couple	VBN
cord-001835-0s7ok4uw	2089	21	folding	folding	NN
cord-001835-0s7ok4uw	2089	22	and	and	CC
cord-001835-0s7ok4uw	2089	23	binding	binding	NN
cord-001835-0s7ok4uw	2089	24	.	.	.
cord-001835-0s7ok4uw	2090	1	In	in	IN
cord-001835-0s7ok4uw	2090	2	the	the	DT
cord-001835-0s7ok4uw	2090	3	case	case	NN
cord-001835-0s7ok4uw	2090	4	of	of	IN
cord-001835-0s7ok4uw	2090	5	alpha	alpha	NN
cord-001835-0s7ok4uw	2090	6	-	-	HYPH
cord-001835-0s7ok4uw	2090	7	synuclein	synuclein	NNP
cord-001835-0s7ok4uw	2090	8	,	,	,
cord-001835-0s7ok4uw	2090	9	the	the	DT
cord-001835-0s7ok4uw	2090	10	beta	beta	NN
cord-001835-0s7ok4uw	2090	11	-	-	HYPH
cord-001835-0s7ok4uw	2090	12	hairpin	hairpin	NN
cord-001835-0s7ok4uw	2090	13	is	be	VBZ
cord-001835-0s7ok4uw	2090	14	formed	form	VBN
cord-001835-0s7ok4uw	2090	15	in	in	IN
cord-001835-0s7ok4uw	2090	16	the	the	DT
cord-001835-0s7ok4uw	2090	17	sequence	sequence	NN
cord-001835-0s7ok4uw	2090	18	region	region	NN
cord-001835-0s7ok4uw	2090	19	35	35	CD
cord-001835-0s7ok4uw	2090	20	-	-	SYM
cord-001835-0s7ok4uw	2090	21	59	59	CD
cord-001835-0s7ok4uw	2090	22	which	which	WDT
cord-001835-0s7ok4uw	2090	23	contains	contain	VBZ
cord-001835-0s7ok4uw	2090	24	the	the	DT
cord-001835-0s7ok4uw	2090	25	beta	beta	JJ
cord-001835-0s7ok4uw	2090	26	-	-	HYPH
cord-001835-0s7ok4uw	2090	27	strand	strand	NN
cord-001835-0s7ok4uw	2090	28	segments	segment	NNS
cord-001835-0s7ok4uw	2090	29	b1	b1	NN
cord-001835-0s7ok4uw	2090	30	and	and	CC
cord-001835-0s7ok4uw	2090	31	b2	b2	NN
cord-001835-0s7ok4uw	2090	32	of	of	IN
cord-001835-0s7ok4uw	2090	33	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2090	34	fibril	fibril	NNP
cord-001835-0s7ok4uw	2090	35	models	model	NNS
cord-001835-0s7ok4uw	2090	36	and	and	CC
cord-001835-0s7ok4uw	2090	37	most	most	JJS
cord-001835-0s7ok4uw	2090	38	disease	disease	NN
cord-001835-0s7ok4uw	2090	39	-	-	HYPH
cord-001835-0s7ok4uw	2090	40	related	relate	VBN
cord-001835-0s7ok4uw	2090	41	mutations	mutation	NNS
cord-001835-0s7ok4uw	2090	42	.	.	.
cord-001835-0s7ok4uw	2091	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2091	2	show	show	VBP
cord-001835-0s7ok4uw	2091	3	by	by	IN
cord-001835-0s7ok4uw	2091	4	disulfide	disulfide	NN
cord-001835-0s7ok4uw	2091	5	engineering	engineering	NN
cord-001835-0s7ok4uw	2091	6	,	,	,
cord-001835-0s7ok4uw	2091	7	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	2091	8	techniques	technique	NNS
cord-001835-0s7ok4uw	2091	9	,	,	,
cord-001835-0s7ok4uw	2091	10	and	and	CC
cord-001835-0s7ok4uw	2091	11	cell	cell	NN
cord-001835-0s7ok4uw	2091	12	viability	viability	NN
cord-001835-0s7ok4uw	2091	13	assays	assay	NNS
cord-001835-0s7ok4uw	2091	14	that	that	WDT
cord-001835-0s7ok4uw	2091	15	intramolecular	intramolecular	JJ
cord-001835-0s7ok4uw	2091	16	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	2091	17	interactions	interaction	NNS
cord-001835-0s7ok4uw	2091	18	between	between	IN
cord-001835-0s7ok4uw	2091	19	the	the	DT
cord-001835-0s7ok4uw	2091	20	b1	b1	NN
cord-001835-0s7ok4uw	2091	21	and	and	CC
cord-001835-0s7ok4uw	2091	22	b2	b2	NN
cord-001835-0s7ok4uw	2091	23	segments	segment	NNS
cord-001835-0s7ok4uw	2091	24	of	of	IN
cord-001835-0s7ok4uw	2091	25	alpha	alpha	NN
cord-001835-0s7ok4uw	2091	26	-	-	HYPH
cord-001835-0s7ok4uw	2091	27	synuclein	synuclein	NN
cord-001835-0s7ok4uw	2091	28	interfere	interfere	VB
cord-001835-0s7ok4uw	2091	29	with	with	IN
cord-001835-0s7ok4uw	2091	30	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2091	31	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2091	32	,	,	,
cord-001835-0s7ok4uw	2091	33	and	and	CC
cord-001835-0s7ok4uw	2091	34	moreover	moreover	RB
cord-001835-0s7ok4uw	2091	35	inhibit	inhibit	VB
cord-001835-0s7ok4uw	2091	36	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2091	37	of	of	IN
cord-001835-0s7ok4uw	2091	38	amyloid	amyloid	JJ
cord-001835-0s7ok4uw	2091	39	-	-	HYPH
cord-001835-0s7ok4uw	2091	40	beta	beta	NN
cord-001835-0s7ok4uw	2091	41	peptide	peptide	NN
cord-001835-0s7ok4uw	2091	42	and	and	CC
cord-001835-0s7ok4uw	2091	43	islet	islet	NN
cord-001835-0s7ok4uw	2091	44	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2091	45	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	2091	46	.	.	.
cord-001835-0s7ok4uw	2092	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2092	2	results	result	NNS
cord-001835-0s7ok4uw	2092	3	reveal	reveal	VBP
cord-001835-0s7ok4uw	2092	4	a	a	DT
cord-001835-0s7ok4uw	2092	5	common	common	JJ
cord-001835-0s7ok4uw	2092	6	preference	preference	NN
cord-001835-0s7ok4uw	2092	7	of	of	IN
cord-001835-0s7ok4uw	2092	8	different	different	JJ
cord-001835-0s7ok4uw	2092	9	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	2092	10	proteins	protein	NNS
cord-001835-0s7ok4uw	2092	11	for	for	IN
cord-001835-0s7ok4uw	2092	12	formation	formation	NN
cord-001835-0s7ok4uw	2092	13	of	of	IN
cord-001835-0s7ok4uw	2092	14	beta	beta	NN
cord-001835-0s7ok4uw	2092	15	-	-	HYPH
cord-001835-0s7ok4uw	2092	16	hairpin	hairpin	JJ
cord-001835-0s7ok4uw	2092	17	motifs	motif	NNS
cord-001835-0s7ok4uw	2092	18	and	and	CC
cord-001835-0s7ok4uw	2092	19	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	2092	20	a	a	DT
cord-001835-0s7ok4uw	2092	21	critical	critical	JJ
cord-001835-0s7ok4uw	2092	22	role	role	NN
cord-001835-0s7ok4uw	2092	23	of	of	IN
cord-001835-0s7ok4uw	2092	24	hairpin	hairpin	JJ
cord-001835-0s7ok4uw	2092	25	conformers	conformer	NNS
cord-001835-0s7ok4uw	2092	26	in	in	IN
cord-001835-0s7ok4uw	2092	27	the	the	DT
cord-001835-0s7ok4uw	2092	28	control	control	NN
cord-001835-0s7ok4uw	2092	29	of	of	IN
cord-001835-0s7ok4uw	2092	30	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2092	31	formation	formation	NN
cord-001835-0s7ok4uw	2092	32	.	.	.
cord-001835-0s7ok4uw	2093	1	Interaction	interaction	NN
cord-001835-0s7ok4uw	2093	2	Profiling	profile	VBG
cord-001835-0s7ok4uw	2093	3	through	through	IN
cord-001835-0s7ok4uw	2093	4	Proteomic	Proteomic	NNP
cord-001835-0s7ok4uw	2093	5	Peptide	Peptide	NNP
cord-001835-0s7ok4uw	2093	6	Phage	Phage	NNP
cord-001835-0s7ok4uw	2094	1	Display	display	NN
cord-001835-0s7ok4uw	2094	2	Cecilia	Cecilia	NNP
cord-001835-0s7ok4uw	2094	3	Blikstad	Blikstad	NNP
cord-001835-0s7ok4uw	2094	4	1	1	CD
cord-001835-0s7ok4uw	2094	5	,	,	,
cord-001835-0s7ok4uw	2095	1	Moon	Moon	NNP
cord-001835-0s7ok4uw	2095	2	-	-	HYPH
cord-001835-0s7ok4uw	2095	3	Hyeong	Hyeong	NNP
cord-001835-0s7ok4uw	2095	4	Seo	Seo	NNP
cord-001835-0s7ok4uw	2095	5	2	2	CD
cord-001835-0s7ok4uw	2095	6	,	,	,
cord-001835-0s7ok4uw	2095	7	Norman	Norman	NNP
cord-001835-0s7ok4uw	2095	8	Davey	Davey	NNP
cord-001835-0s7ok4uw	2095	9	3	3	CD
cord-001835-0s7ok4uw	2096	1	,	,	,
cord-001835-0s7ok4uw	2096	2	Roland	Roland	NNP
cord-001835-0s7ok4uw	2096	3	Arnold	Arnold	NNP
cord-001835-0s7ok4uw	2096	4	2	2	CD
cord-001835-0s7ok4uw	2096	5	,	,	,
cord-001835-0s7ok4uw	2096	6	Sachdev	Sachdev	NNP
cord-001835-0s7ok4uw	2096	7	S	S	NNP
cord-001835-0s7ok4uw	2096	8	Sidhu	Sidhu	NNP
cord-001835-0s7ok4uw	2096	9	2	2	CD
cord-001835-0s7ok4uw	2096	10	,	,	,
cord-001835-0s7ok4uw	2096	11	Philip	Philip	NNP
cord-001835-0s7ok4uw	2096	12	M	M	NNP
cord-001835-0s7ok4uw	2096	13	Kim	Kim	NNP
cord-001835-0s7ok4uw	2096	14	2	2	CD
cord-001835-0s7ok4uw	2096	15	,	,	,
cord-001835-0s7ok4uw	2096	16	Ylva	Ylva	NNP
cord-001835-0s7ok4uw	2096	17	Ivarsson	Ivarsson	NNP
cord-001835-0s7ok4uw	2096	18	1	1	CD
cord-001835-0s7ok4uw	2096	19	1	1	CD
cord-001835-0s7ok4uw	2096	20	Department	Department	NNP
cord-001835-0s7ok4uw	2096	21	of	of	IN
cord-001835-0s7ok4uw	2096	22	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	2096	23	-BMC	-BMC	:
cord-001835-0s7ok4uw	2096	24	,	,	,
cord-001835-0s7ok4uw	2096	25	2	2	CD
cord-001835-0s7ok4uw	2096	26	Donnelly	Donnelly	NNP
cord-001835-0s7ok4uw	2096	27	Centre	Centre	NNP
cord-001835-0s7ok4uw	2096	28	A	a	DT
cord-001835-0s7ok4uw	2096	29	considerable	considerable	JJ
cord-001835-0s7ok4uw	2096	30	part	part	NN
cord-001835-0s7ok4uw	2096	31	of	of	IN
cord-001835-0s7ok4uw	2096	32	the	the	DT
cord-001835-0s7ok4uw	2096	33	human	human	JJ
cord-001835-0s7ok4uw	2096	34	proteome	proteome	NN
cord-001835-0s7ok4uw	2096	35	is	be	VBZ
cord-001835-0s7ok4uw	2096	36	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2096	37	disordered	disordered	JJ
cord-001835-0s7ok4uw	2096	38	.	.	.
cord-001835-0s7ok4uw	2097	1	The	the	DT
cord-001835-0s7ok4uw	2097	2	disordered	disordered	JJ
cord-001835-0s7ok4uw	2097	3	regions	region	NNS
cord-001835-0s7ok4uw	2097	4	are	be	VBP
cord-001835-0s7ok4uw	2097	5	enriched	enrich	VBN
cord-001835-0s7ok4uw	2097	6	in	in	IN
cord-001835-0s7ok4uw	2097	7	short	short	JJ
cord-001835-0s7ok4uw	2097	8	motifs	motif	NNS
cord-001835-0s7ok4uw	2097	9	serving	serve	VBG
cord-001835-0s7ok4uw	2097	10	as	as	IN
cord-001835-0s7ok4uw	2097	11	docking	docking	NN
cord-001835-0s7ok4uw	2097	12	sites	site	NNS
cord-001835-0s7ok4uw	2097	13	for	for	IN
cord-001835-0s7ok4uw	2097	14	peptide	peptide	NN
cord-001835-0s7ok4uw	2097	15	binding	binding	NN
cord-001835-0s7ok4uw	2097	16	domains	domain	NNS
cord-001835-0s7ok4uw	2097	17	.	.	.
cord-001835-0s7ok4uw	2098	1	Domain	domain	NN
cord-001835-0s7ok4uw	2098	2	-	-	HYPH
cord-001835-0s7ok4uw	2098	3	motif	motif	NN
cord-001835-0s7ok4uw	2098	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	2098	5	are	be	VBP
cord-001835-0s7ok4uw	2098	6	crucial	crucial	JJ
cord-001835-0s7ok4uw	2098	7	for	for	IN
cord-001835-0s7ok4uw	2098	8	the	the	DT
cord-001835-0s7ok4uw	2098	9	wiring	wiring	NN
cord-001835-0s7ok4uw	2098	10	of	of	IN
cord-001835-0s7ok4uw	2098	11	signaling	signal	VBG
cord-001835-0s7ok4uw	2098	12	pathways	pathway	NNS
cord-001835-0s7ok4uw	2098	13	.	.	.
cord-001835-0s7ok4uw	2099	1	These	these	DT
cord-001835-0s7ok4uw	2099	2	interactions	interaction	NNS
cord-001835-0s7ok4uw	2099	3	are	be	VBP
cord-001835-0s7ok4uw	2099	4	typically	typically	RB
cord-001835-0s7ok4uw	2099	5	transient	transient	JJ
cord-001835-0s7ok4uw	2099	6	and	and	CC
cord-001835-0s7ok4uw	2099	7	difficult	difficult	JJ
cord-001835-0s7ok4uw	2099	8	to	to	TO
cord-001835-0s7ok4uw	2099	9	capture	capture	VB
cord-001835-0s7ok4uw	2099	10	through	through	IN
cord-001835-0s7ok4uw	2099	11	most	most	JJS
cord-001835-0s7ok4uw	2099	12	conventional	conventional	JJ
cord-001835-0s7ok4uw	2099	13	high	high	JJ
cord-001835-0s7ok4uw	2099	14	-	-	HYPH
cord-001835-0s7ok4uw	2099	15	throughput	throughput	NN
cord-001835-0s7ok4uw	2099	16	methods	method	NNS
cord-001835-0s7ok4uw	2099	17	.	.	.
cord-001835-0s7ok4uw	2100	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2100	2	therefore	therefore	RB
cord-001835-0s7ok4uw	2100	3	developed	develop	VBD
cord-001835-0s7ok4uw	2100	4	a	a	DT
cord-001835-0s7ok4uw	2100	5	novel	novel	JJ
cord-001835-0s7ok4uw	2100	6	approach	approach	NN
cord-001835-0s7ok4uw	2100	7	for	for	IN
cord-001835-0s7ok4uw	2100	8	the	the	DT
cord-001835-0s7ok4uw	2100	9	large	large	JJ
cord-001835-0s7ok4uw	2100	10	-	-	HYPH
cord-001835-0s7ok4uw	2100	11	scale	scale	NN
cord-001835-0s7ok4uw	2100	12	profiling	profiling	NN
cord-001835-0s7ok4uw	2100	13	of	of	IN
cord-001835-0s7ok4uw	2100	14	domain	domain	NN
cord-001835-0s7ok4uw	2100	15	-	-	HYPH
cord-001835-0s7ok4uw	2100	16	motifs	motifs	NN
cord-001835-0s7ok4uw	2100	17	interactions	interaction	NNS
cord-001835-0s7ok4uw	2100	18	called	call	VBN
cord-001835-0s7ok4uw	2100	19	Proteomic	Proteomic	NNP
cord-001835-0s7ok4uw	2100	20	Peptide	Peptide	NNP
cord-001835-0s7ok4uw	2100	21	Phage	Phage	NNP
cord-001835-0s7ok4uw	2100	22	Display	display	NN
cord-001835-0s7ok4uw	2100	23	(	(	-LRB-
cord-001835-0s7ok4uw	2100	24	ProP	ProP	NNP
cord-001835-0s7ok4uw	2100	25	-	-	HYPH
cord-001835-0s7ok4uw	2100	26	PD	PD	NNP
cord-001835-0s7ok4uw	2100	27	)	)	-RRB-
cord-001835-0s7ok4uw	2100	28	(	(	-LRB-
cord-001835-0s7ok4uw	2100	29	1	1	CD
cord-001835-0s7ok4uw	2100	30	)	)	-RRB-
cord-001835-0s7ok4uw	2100	31	.	.	.
cord-001835-0s7ok4uw	2101	1	In	in	IN
cord-001835-0s7ok4uw	2101	2	ProP	ProP	NNP
cord-001835-0s7ok4uw	2101	3	-	-	HYPH
cord-001835-0s7ok4uw	2101	4	PD	PD	NNP
cord-001835-0s7ok4uw	2101	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2101	6	combine	combine	VBP
cord-001835-0s7ok4uw	2101	7	bioinformatics	bioinformatic	NNS
cord-001835-0s7ok4uw	2101	8	,	,	,
cord-001835-0s7ok4uw	2101	9	oligonucleotide	oligonucleotide	JJ
cord-001835-0s7ok4uw	2101	10	arrays	array	NNS
cord-001835-0s7ok4uw	2101	11	,	,	,
cord-001835-0s7ok4uw	2101	12	peptide	peptide	NN
cord-001835-0s7ok4uw	2101	13	phage	phage	NN
cord-001835-0s7ok4uw	2101	14	display	display	NN
cord-001835-0s7ok4uw	2101	15	and	and	CC
cord-001835-0s7ok4uw	2101	16	next	next	JJ
cord-001835-0s7ok4uw	2101	17	-	-	HYPH
cord-001835-0s7ok4uw	2101	18	generation	generation	NN
cord-001835-0s7ok4uw	2101	19	sequencing	sequencing	NN
cord-001835-0s7ok4uw	2101	20	.	.	.
cord-001835-0s7ok4uw	2102	1	This	this	DT
cord-001835-0s7ok4uw	2102	2	allows	allow	VBZ
cord-001835-0s7ok4uw	2102	3	the	the	DT
cord-001835-0s7ok4uw	2102	4	interrogation	interrogation	NN
cord-001835-0s7ok4uw	2102	5	of	of	IN
cord-001835-0s7ok4uw	2102	6	domain	domain	NN
cord-001835-0s7ok4uw	2102	7	-	-	HYPH
cord-001835-0s7ok4uw	2102	8	motif	motif	NN
cord-001835-0s7ok4uw	2102	9	interactions	interaction	NNS
cord-001835-0s7ok4uw	2102	10	on	on	IN
cord-001835-0s7ok4uw	2102	11	a	a	DT
cord-001835-0s7ok4uw	2102	12	proteome	proteome	NN
cord-001835-0s7ok4uw	2102	13	-	-	HYPH
cord-001835-0s7ok4uw	2102	14	wide	wide	JJ
cord-001835-0s7ok4uw	2102	15	scale	scale	NN
cord-001835-0s7ok4uw	2102	16	and	and	CC
cord-001835-0s7ok4uw	2102	17	the	the	DT
cord-001835-0s7ok4uw	2102	18	de	de	FW
cord-001835-0s7ok4uw	2102	19	novo	novo	NNP
cord-001835-0s7ok4uw	2102	20	motif	motif	NNP
cord-001835-0s7ok4uw	2102	21	discovery	discovery	NN
cord-001835-0s7ok4uw	2102	22	.	.	.
cord-001835-0s7ok4uw	2103	1	In	in	IN
cord-001835-0s7ok4uw	2103	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2103	3	pilot	pilot	NN
cord-001835-0s7ok4uw	2103	4	experiment	experiment	NN
cord-001835-0s7ok4uw	2103	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2103	6	generated	generate	VBD
cord-001835-0s7ok4uw	2103	7	two	two	CD
cord-001835-0s7ok4uw	2103	8	distinct	distinct	JJ
cord-001835-0s7ok4uw	2103	9	phage	phage	NN
cord-001835-0s7ok4uw	2103	10	libraries	library	NNS
cord-001835-0s7ok4uw	2103	11	,	,	,
cord-001835-0s7ok4uw	2103	12	one	one	CD
cord-001835-0s7ok4uw	2103	13	displaying	display	VBG
cord-001835-0s7ok4uw	2103	14	all	all	DT
cord-001835-0s7ok4uw	2103	15	human	human	JJ
cord-001835-0s7ok4uw	2103	16	C	c	NN
cord-001835-0s7ok4uw	2103	17	-	-	HYPH
cord-001835-0s7ok4uw	2103	18	terminal	terminal	NN
cord-001835-0s7ok4uw	2103	19	sequences	sequence	NNS
cord-001835-0s7ok4uw	2103	20	and	and	CC
cord-001835-0s7ok4uw	2103	21	one	one	CD
cord-001835-0s7ok4uw	2103	22	displaying	display	VBG
cord-001835-0s7ok4uw	2103	23	C	c	NN
cord-001835-0s7ok4uw	2103	24	-	-	HYPH
cord-001835-0s7ok4uw	2103	25	termini	terminus	NNS
cord-001835-0s7ok4uw	2103	26	of	of	IN
cord-001835-0s7ok4uw	2103	27	known	know	VBN
cord-001835-0s7ok4uw	2103	28	virus	virus	NN
cord-001835-0s7ok4uw	2103	29	proteins	protein	NNS
cord-001835-0s7ok4uw	2103	30	.	.	.
cord-001835-0s7ok4uw	2104	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2104	2	used	use	VBD
cord-001835-0s7ok4uw	2104	3	the	the	DT
cord-001835-0s7ok4uw	2104	4	ProP	ProP	NNP
cord-001835-0s7ok4uw	2104	5	-	-	HYPH
cord-001835-0s7ok4uw	2104	6	PD	PD	NNP
cord-001835-0s7ok4uw	2104	7	libraries	library	NNS
cord-001835-0s7ok4uw	2104	8	to	to	TO
cord-001835-0s7ok4uw	2104	9	identify	identify	VB
cord-001835-0s7ok4uw	2104	10	interactions	interaction	NNS
cord-001835-0s7ok4uw	2104	11	of	of	IN
cord-001835-0s7ok4uw	2104	12	human	human	JJ
cord-001835-0s7ok4uw	2104	13	postsynaptic	postsynaptic	JJ
cord-001835-0s7ok4uw	2104	14	density	density	NN
cord-001835-0s7ok4uw	2104	15	95	95	CD
cord-001835-0s7ok4uw	2104	16	/	/	SYM
cord-001835-0s7ok4uw	2104	17	discs	disc	NNS
cord-001835-0s7ok4uw	2104	18	large	large	JJ
cord-001835-0s7ok4uw	2105	1	/zonula	/zonula	,
cord-001835-0s7ok4uw	2105	2	occludens-1	occludens-1	NNP
cord-001835-0s7ok4uw	2105	3	(	(	-LRB-
cord-001835-0s7ok4uw	2105	4	PDZ	PDZ	NNP
cord-001835-0s7ok4uw	2105	5	)	)	-RRB-
cord-001835-0s7ok4uw	2105	6	domains	domain	NNS
cord-001835-0s7ok4uw	2105	7	.	.	.
cord-001835-0s7ok4uw	2106	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2106	2	successfully	successfully	RB
cord-001835-0s7ok4uw	2106	3	identified	identify	VBD
cord-001835-0s7ok4uw	2106	4	novel	novel	NN
cord-001835-0s7ok4uw	2106	5	PDZ	PDZ	NNP
cord-001835-0s7ok4uw	2106	6	domain	domain	NN
cord-001835-0s7ok4uw	2106	7	interactions	interaction	NNS
cord-001835-0s7ok4uw	2106	8	of	of	IN
cord-001835-0s7ok4uw	2106	9	potential	potential	JJ
cord-001835-0s7ok4uw	2106	10	relevance	relevance	NN
cord-001835-0s7ok4uw	2106	11	to	to	IN
cord-001835-0s7ok4uw	2106	12	cellular	cellular	JJ
cord-001835-0s7ok4uw	2106	13	signaling	signal	VBG
cord-001835-0s7ok4uw	2106	14	pathways	pathway	NNS
cord-001835-0s7ok4uw	2106	15	and	and	CC
cord-001835-0s7ok4uw	2106	16	validated	validate	VBD
cord-001835-0s7ok4uw	2106	17	a	a	DT
cord-001835-0s7ok4uw	2106	18	subset	subset	NN
cord-001835-0s7ok4uw	2106	19	of	of	IN
cord-001835-0s7ok4uw	2106	20	interactions	interaction	NNS
cord-001835-0s7ok4uw	2106	21	with	with	IN
cord-001835-0s7ok4uw	2106	22	a	a	DT
cord-001835-0s7ok4uw	2106	23	high	high	JJ
cord-001835-0s7ok4uw	2106	24	success	success	NN
cord-001835-0s7ok4uw	2106	25	rate	rate	NN
cord-001835-0s7ok4uw	2106	26	.	.	.
cord-001835-0s7ok4uw	2107	1	Recently	recently	RB
cord-001835-0s7ok4uw	2107	2	,	,	,
cord-001835-0s7ok4uw	2107	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2107	4	created	create	VBD
cord-001835-0s7ok4uw	2107	5	a	a	DT
cord-001835-0s7ok4uw	2107	6	ProP	ProP	NNP
cord-001835-0s7ok4uw	2107	7	-	-	HYPH
cord-001835-0s7ok4uw	2107	8	PD	PD	NNP
cord-001835-0s7ok4uw	2107	9	library	library	NN
cord-001835-0s7ok4uw	2107	10	that	that	WDT
cord-001835-0s7ok4uw	2107	11	displays	display	VBZ
cord-001835-0s7ok4uw	2107	12	peptides	peptide	NNS
cord-001835-0s7ok4uw	2107	13	representing	represent	VBG
cord-001835-0s7ok4uw	2107	14	the	the	DT
cord-001835-0s7ok4uw	2107	15	disordered	disordered	JJ
cord-001835-0s7ok4uw	2107	16	regions	region	NNS
cord-001835-0s7ok4uw	2107	17	of	of	IN
cord-001835-0s7ok4uw	2107	18	the	the	DT
cord-001835-0s7ok4uw	2107	19	human	human	JJ
cord-001835-0s7ok4uw	2107	20	proteome	proteome	NN
cord-001835-0s7ok4uw	2107	21	.	.	.
cord-001835-0s7ok4uw	2108	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2108	2	validate	validate	VBP
cord-001835-0s7ok4uw	2108	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2108	4	disorderome	disorderome	NN
cord-001835-0s7ok4uw	2108	5	library	library	NN
cord-001835-0s7ok4uw	2108	6	against	against	IN
cord-001835-0s7ok4uw	2108	7	a	a	DT
cord-001835-0s7ok4uw	2108	8	range	range	NN
cord-001835-0s7ok4uw	2108	9	of	of	IN
cord-001835-0s7ok4uw	2108	10	peptide	peptide	NN
cord-001835-0s7ok4uw	2108	11	binding	binding	NN
cord-001835-0s7ok4uw	2108	12	domains	domain	NNS
cord-001835-0s7ok4uw	2108	13	,	,	,
cord-001835-0s7ok4uw	2108	14	which	which	WDT
cord-001835-0s7ok4uw	2108	15	provides	provide	VBZ
cord-001835-0s7ok4uw	2108	16	novel	novel	JJ
cord-001835-0s7ok4uw	2108	17	insights	insight	NNS
cord-001835-0s7ok4uw	2108	18	into	into	IN
cord-001835-0s7ok4uw	2108	19	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2108	20	binding	binding	NN
cord-001835-0s7ok4uw	2108	21	preferences	preference	NNS
cord-001835-0s7ok4uw	2108	22	and	and	CC
cord-001835-0s7ok4uw	2108	23	suggest	suggest	VBP
cord-001835-0s7ok4uw	2108	24	interactions	interaction	NNS
cord-001835-0s7ok4uw	2108	25	of	of	IN
cord-001835-0s7ok4uw	2108	26	potential	potential	JJ
cord-001835-0s7ok4uw	2108	27	biological	biological	JJ
cord-001835-0s7ok4uw	2108	28	relevance	relevance	NN
cord-001835-0s7ok4uw	2108	29	as	as	IN
cord-001835-0s7ok4uw	2108	30	will	will	MD
cord-001835-0s7ok4uw	2108	31	be	be	VB
cord-001835-0s7ok4uw	2108	32	presented	present	VBN
cord-001835-0s7ok4uw	2108	33	here	here	RB
cord-001835-0s7ok4uw	2108	34	.	.	.
cord-001835-0s7ok4uw	2109	1	ProP	ProP	NNP
cord-001835-0s7ok4uw	2109	2	-	-	HYPH
cord-001835-0s7ok4uw	2109	3	PD	PD	NNP
cord-001835-0s7ok4uw	2109	4	can	can	MD
cord-001835-0s7ok4uw	2109	5	be	be	VB
cord-001835-0s7ok4uw	2109	6	used	use	VBN
cord-001835-0s7ok4uw	2109	7	to	to	TO
cord-001835-0s7ok4uw	2109	8	uncover	uncover	VB
cord-001835-0s7ok4uw	2109	9	protein	protein	NN
cord-001835-0s7ok4uw	2109	10	-	-	HYPH
cord-001835-0s7ok4uw	2109	11	protein	protein	NN
cord-001835-0s7ok4uw	2109	12	interactions	interaction	NNS
cord-001835-0s7ok4uw	2109	13	of	of	IN
cord-001835-0s7ok4uw	2109	14	potential	potential	JJ
cord-001835-0s7ok4uw	2109	15	biological	biological	JJ
cord-001835-0s7ok4uw	2109	16	relevance	relevance	NN
cord-001835-0s7ok4uw	2109	17	in	in	IN
cord-001835-0s7ok4uw	2109	18	high	high	JJ
cord-001835-0s7ok4uw	2109	19	-	-	HYPH
cord-001835-0s7ok4uw	2109	20	throughput	throughput	NN
cord-001835-0s7ok4uw	2109	21	experiments	experiment	NNS
cord-001835-0s7ok4uw	2109	22	and	and	CC
cord-001835-0s7ok4uw	2109	23	provides	provide	VBZ
cord-001835-0s7ok4uw	2109	24	information	information	NN
cord-001835-0s7ok4uw	2109	25	that	that	WDT
cord-001835-0s7ok4uw	2109	26	is	be	VBZ
cord-001835-0s7ok4uw	2109	27	complementary	complementary	JJ
cord-001835-0s7ok4uw	2109	28	to	to	IN
cord-001835-0s7ok4uw	2109	29	other	other	JJ
cord-001835-0s7ok4uw	2109	30	methods	method	NNS
cord-001835-0s7ok4uw	2109	31	.	.	.
cord-001835-0s7ok4uw	2110	1	ProP	ProP	NNP
cord-001835-0s7ok4uw	2110	2	-	-	HYPH
cord-001835-0s7ok4uw	2110	3	PD	PD	NNP
cord-001835-0s7ok4uw	2110	4	is	be	VBZ
cord-001835-0s7ok4uw	2110	5	scalable	scalable	JJ
cord-001835-0s7ok4uw	2110	6	and	and	CC
cord-001835-0s7ok4uw	2110	7	can	can	MD
cord-001835-0s7ok4uw	2110	8	be	be	VB
cord-001835-0s7ok4uw	2110	9	developed	develop	VBN
cord-001835-0s7ok4uw	2110	10	to	to	IN
cord-001835-0s7ok4uw	2110	11	any	any	DT
cord-001835-0s7ok4uw	2110	12	target	target	NN
cord-001835-0s7ok4uw	2110	13	proteome	proteome	NN
cord-001835-0s7ok4uw	2110	14	of	of	IN
cord-001835-0s7ok4uw	2110	15	interest	interest	NN
cord-001835-0s7ok4uw	2110	16	.	.	.
cord-001835-0s7ok4uw	2111	1	Phosducin	Phosducin	NNP
cord-001835-0s7ok4uw	2111	2	is	be	VBZ
cord-001835-0s7ok4uw	2111	3	a	a	DT
cord-001835-0s7ok4uw	2111	4	30	30	CD
cord-001835-0s7ok4uw	2111	5	kDa	kDa	NNS
cord-001835-0s7ok4uw	2111	6	phosphoprotein	phosphoprotein	NN
cord-001835-0s7ok4uw	2111	7	that	that	WDT
cord-001835-0s7ok4uw	2111	8	regulates	regulate	VBZ
cord-001835-0s7ok4uw	2111	9	visual	visual	JJ
cord-001835-0s7ok4uw	2111	10	signal	signal	NN
cord-001835-0s7ok4uw	2111	11	transduction	transduction	NN
cord-001835-0s7ok4uw	2111	12	by	by	IN
cord-001835-0s7ok4uw	2111	13	interacting	interact	VBG
cord-001835-0s7ok4uw	2111	14	with	with	IN
cord-001835-0s7ok4uw	2111	15	the	the	DT
cord-001835-0s7ok4uw	2111	16	Gtbg	Gtbg	NNP
cord-001835-0s7ok4uw	2111	17	;	;	,
cord-001835-0s7ok4uw	2111	18	subunit	subunit	NN
cord-001835-0s7ok4uw	2111	19	of	of	IN
cord-001835-0s7ok4uw	2111	20	the	the	DT
cord-001835-0s7ok4uw	2111	21	retinal	retinal	JJ
cord-001835-0s7ok4uw	2111	22	G	g	NN
cord-001835-0s7ok4uw	2111	23	-	-	HYPH
cord-001835-0s7ok4uw	2111	24	protein	protein	NN
cord-001835-0s7ok4uw	2111	25	transducin	transducin	NNS
cord-001835-0s7ok4uw	2111	26	.	.	.
cord-001835-0s7ok4uw	2112	1	The	the	DT
cord-001835-0s7ok4uw	2112	2	function	function	NN
cord-001835-0s7ok4uw	2112	3	of	of	IN
cord-001835-0s7ok4uw	2112	4	Pdc	Pdc	NNP
cord-001835-0s7ok4uw	2112	5	is	be	VBZ
cord-001835-0s7ok4uw	2112	6	regulated	regulate	VBN
cord-001835-0s7ok4uw	2112	7	by	by	IN
cord-001835-0s7ok4uw	2112	8	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	2112	9	at	at	IN
cord-001835-0s7ok4uw	2112	10	Ser54	Ser54	NNP
cord-001835-0s7ok4uw	2112	11	and	and	CC
cord-001835-0s7ok4uw	2112	12	Ser73	Ser73	NNP
cord-001835-0s7ok4uw	2112	13	in	in	IN
cord-001835-0s7ok4uw	2112	14	a	a	DT
cord-001835-0s7ok4uw	2112	15	process	process	NN
cord-001835-0s7ok4uw	2112	16	that	that	WDT
cord-001835-0s7ok4uw	2112	17	involves	involve	VBZ
cord-001835-0s7ok4uw	2112	18	the	the	DT
cord-001835-0s7ok4uw	2112	19	binding	binding	NN
cord-001835-0s7ok4uw	2112	20	of	of	IN
cord-001835-0s7ok4uw	2112	21	phosphorylated	phosphorylated	JJ
cord-001835-0s7ok4uw	2112	22	Pdc	Pdc	NNP
cord-001835-0s7ok4uw	2112	23	to	to	IN
cord-001835-0s7ok4uw	2112	24	the	the	DT
cord-001835-0s7ok4uw	2112	25	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	2112	26	14	14	CD
cord-001835-0s7ok4uw	2112	27	-	-	SYM
cord-001835-0s7ok4uw	2112	28	3	3	CD
cord-001835-0s7ok4uw	2112	29	-	-	SYM
cord-001835-0s7ok4uw	2112	30	3	3	CD
cord-001835-0s7ok4uw	2112	31	protein	protein	NN
cord-001835-0s7ok4uw	2112	32	,	,	,
cord-001835-0s7ok4uw	2112	33	but	but	CC
cord-001835-0s7ok4uw	2112	34	the	the	DT
cord-001835-0s7ok4uw	2112	35	molecular	molecular	JJ
cord-001835-0s7ok4uw	2112	36	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2112	37	of	of	IN
cord-001835-0s7ok4uw	2112	38	the	the	DT
cord-001835-0s7ok4uw	2112	39	regulation	regulation	NN
cord-001835-0s7ok4uw	2112	40	by	by	IN
cord-001835-0s7ok4uw	2112	41	14	14	CD
cord-001835-0s7ok4uw	2112	42	-	-	SYM
cord-001835-0s7ok4uw	2112	43	3	3	CD
cord-001835-0s7ok4uw	2112	44	-	-	SYM
cord-001835-0s7ok4uw	2112	45	3	3	CD
cord-001835-0s7ok4uw	2112	46	protein	protein	NN
cord-001835-0s7ok4uw	2112	47	is	be	VBZ
cord-001835-0s7ok4uw	2112	48	still	still	RB
cord-001835-0s7ok4uw	2112	49	unknown	unknown	JJ
cord-001835-0s7ok4uw	2112	50	.	.	.
cord-001835-0s7ok4uw	2113	1	Pdc	Pdc	NNP
cord-001835-0s7ok4uw	2113	2	was	be	VBD
cord-001835-0s7ok4uw	2113	3	also	also	RB
cord-001835-0s7ok4uw	2113	4	suggested	suggest	VBN
cord-001835-0s7ok4uw	2113	5	to	to	TO
cord-001835-0s7ok4uw	2113	6	be	be	VB
cord-001835-0s7ok4uw	2113	7	involved	involve	VBN
cord-001835-0s7ok4uw	2113	8	in	in	IN
cord-001835-0s7ok4uw	2113	9	transcriptional	transcriptional	JJ
cord-001835-0s7ok4uw	2113	10	control	control	NN
cord-001835-0s7ok4uw	2113	11	,	,	,
cord-001835-0s7ok4uw	2113	12	the	the	DT
cord-001835-0s7ok4uw	2113	13	regulation	regulation	NN
cord-001835-0s7ok4uw	2113	14	of	of	IN
cord-001835-0s7ok4uw	2113	15	transmission	transmission	NN
cord-001835-0s7ok4uw	2113	16	at	at	IN
cord-001835-0s7ok4uw	2113	17	the	the	DT
cord-001835-0s7ok4uw	2113	18	photoreceptorto	photoreceptorto	NN
cord-001835-0s7ok4uw	2113	19	-	-	HYPH
cord-001835-0s7ok4uw	2113	20	ON	on	IN
cord-001835-0s7ok4uw	2113	21	-	-	HYPH
cord-001835-0s7ok4uw	2113	22	bipolar	bipolar	JJ
cord-001835-0s7ok4uw	2113	23	cell	cell	NN
cord-001835-0s7ok4uw	2113	24	synapse	synapse	NN
cord-001835-0s7ok4uw	2113	25	,	,	,
cord-001835-0s7ok4uw	2113	26	and	and	CC
cord-001835-0s7ok4uw	2113	27	the	the	DT
cord-001835-0s7ok4uw	2113	28	regulation	regulation	NN
cord-001835-0s7ok4uw	2113	29	of	of	IN
cord-001835-0s7ok4uw	2113	30	the	the	DT
cord-001835-0s7ok4uw	2113	31	sympathetic	sympathetic	JJ
cord-001835-0s7ok4uw	2113	32	activity	activity	NN
cord-001835-0s7ok4uw	2113	33	and	and	CC
cord-001835-0s7ok4uw	2113	34	blood	blood	NN
cord-001835-0s7ok4uw	2113	35	pressure	pressure	NN
cord-001835-0s7ok4uw	2113	36	[	[	-LRB-
cord-001835-0s7ok4uw	2113	37	1	1	CD
cord-001835-0s7ok4uw	2113	38	]	]	-RRB-
cord-001835-0s7ok4uw	2113	39	[	[	-LRB-
cord-001835-0s7ok4uw	2113	40	2	2	CD
cord-001835-0s7ok4uw	2113	41	]	]	-RRB-
cord-001835-0s7ok4uw	2113	42	[	[	-LRB-
cord-001835-0s7ok4uw	2113	43	3	3	CD
cord-001835-0s7ok4uw	2113	44	]	]	-RRB-
cord-001835-0s7ok4uw	2113	45	.	.	.
cord-001835-0s7ok4uw	2114	1	Here	here	RB
cord-001835-0s7ok4uw	2114	2	,	,	,
cord-001835-0s7ok4uw	2114	3	the	the	DT
cord-001835-0s7ok4uw	2114	4	solution	solution	NN
cord-001835-0s7ok4uw	2114	5	structure	structure	NN
cord-001835-0s7ok4uw	2114	6	of	of	IN
cord-001835-0s7ok4uw	2114	7	Pdc	Pdc	NNP
cord-001835-0s7ok4uw	2114	8	and	and	CC
cord-001835-0s7ok4uw	2114	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2114	10	interaction	interaction	NN
cord-001835-0s7ok4uw	2114	11	with	with	IN
cord-001835-0s7ok4uw	2114	12	the	the	DT
cord-001835-0s7ok4uw	2114	13	14	14	CD
cord-001835-0s7ok4uw	2114	14	-	-	SYM
cord-001835-0s7ok4uw	2114	15	3	3	CD
cord-001835-0s7ok4uw	2114	16	-	-	SYM
cord-001835-0s7ok4uw	2114	17	3	3	CD
cord-001835-0s7ok4uw	2114	18	protein	protein	NN
cord-001835-0s7ok4uw	2114	19	were	be	VBD
cord-001835-0s7ok4uw	2114	20	investigated	investigate	VBN
cord-001835-0s7ok4uw	2114	21	using	use	VBG
cord-001835-0s7ok4uw	2114	22	small	small	JJ
cord-001835-0s7ok4uw	2114	23	angle	angle	NN
cord-001835-0s7ok4uw	2114	24	X	x	NN
cord-001835-0s7ok4uw	2114	25	-	-	NN
cord-001835-0s7ok4uw	2114	26	ray	ray	NN
cord-001835-0s7ok4uw	2114	27	scattering	scattering	NN
cord-001835-0s7ok4uw	2114	28	,	,	,
cord-001835-0s7ok4uw	2114	29	circular	circular	JJ
cord-001835-0s7ok4uw	2114	30	dichroism	dichroism	NN
cord-001835-0s7ok4uw	2114	31	,	,	,
cord-001835-0s7ok4uw	2114	32	quenching	quenching	NN
cord-001835-0s7ok4uw	2114	33	of	of	IN
cord-001835-0s7ok4uw	2114	34	tryptophan	tryptophan	NN
cord-001835-0s7ok4uw	2114	35	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2114	36	,	,	,
cord-001835-0s7ok4uw	2114	37	analytical	analytical	JJ
cord-001835-0s7ok4uw	2114	38	ultracentrifugation	ultracentrifugation	NN
cord-001835-0s7ok4uw	2114	39	,	,	,
cord-001835-0s7ok4uw	2114	40	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2114	41	-	-	HYPH
cord-001835-0s7ok4uw	2114	42	deuterium	deuterium	NN
cord-001835-0s7ok4uw	2114	43	exchange	exchange	NN
cord-001835-0s7ok4uw	2114	44	coupled	couple	VBN
cord-001835-0s7ok4uw	2114	45	to	to	IN
cord-001835-0s7ok4uw	2114	46	mass	mass	NN
cord-001835-0s7ok4uw	2114	47	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	2114	48	and	and	CC
cord-001835-0s7ok4uw	2114	49	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	2114	50	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	2114	51	resonance	resonance	NN
cord-001835-0s7ok4uw	2114	52	.	.	.
cord-001835-0s7ok4uw	2115	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2115	2	show	show	VBP
cord-001835-0s7ok4uw	2115	3	that	that	IN
cord-001835-0s7ok4uw	2115	4	the	the	DT
cord-001835-0s7ok4uw	2115	5	14	14	CD
cord-001835-0s7ok4uw	2115	6	-	-	SYM
cord-001835-0s7ok4uw	2115	7	3	3	CD
cord-001835-0s7ok4uw	2115	8	-	-	SYM
cord-001835-0s7ok4uw	2115	9	3	3	CD
cord-001835-0s7ok4uw	2115	10	protein	protein	NN
cord-001835-0s7ok4uw	2115	11	interacts	interact	VBZ
cord-001835-0s7ok4uw	2115	12	with	with	IN
cord-001835-0s7ok4uw	2115	13	and	and	CC
cord-001835-0s7ok4uw	2115	14	sterically	sterically	RB
cord-001835-0s7ok4uw	2115	15	occludes	occlude	VBZ
cord-001835-0s7ok4uw	2115	16	both	both	CC
cord-001835-0s7ok4uw	2115	17	the	the	DT
cord-001835-0s7ok4uw	2115	18	N	N	NNP
cord-001835-0s7ok4uw	2115	19	-	-	HYPH
cord-001835-0s7ok4uw	2115	20	and	and	CC
cord-001835-0s7ok4uw	2115	21	C	C	NNP
cord-001835-0s7ok4uw	2115	22	-	-	HYPH
cord-001835-0s7ok4uw	2115	23	terminal	terminal	NN
cord-001835-0s7ok4uw	2115	24	Gtbg	Gtbg	NNP
cord-001835-0s7ok4uw	2115	25	binding	bind	VBG
cord-001835-0s7ok4uw	2115	26	interfaces	interface	NNS
cord-001835-0s7ok4uw	2115	27	of	of	IN
cord-001835-0s7ok4uw	2115	28	phosphorylated	phosphorylated	JJ
cord-001835-0s7ok4uw	2115	29	Pdc	Pdc	NNP
cord-001835-0s7ok4uw	2115	30	,	,	,
cord-001835-0s7ok4uw	2115	31	thus	thus	RB
cord-001835-0s7ok4uw	2115	32	providing	provide	VBG
cord-001835-0s7ok4uw	2115	33	a	a	DT
cord-001835-0s7ok4uw	2115	34	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	2115	35	explanation	explanation	NN
cord-001835-0s7ok4uw	2115	36	for	for	IN
cord-001835-0s7ok4uw	2115	37	the	the	DT
cord-001835-0s7ok4uw	2115	38	14	14	CD
cord-001835-0s7ok4uw	2115	39	-	-	SYM
cord-001835-0s7ok4uw	2115	40	3	3	CD
cord-001835-0s7ok4uw	2115	41	-	-	HYPH
cord-001835-0s7ok4uw	2115	42	3depedent	3depedent	CD
cord-001835-0s7ok4uw	2115	43	inhibition	inhibition	NN
cord-001835-0s7ok4uw	2115	44	of	of	IN
cord-001835-0s7ok4uw	2115	45	Pdc	Pdc	NNP
cord-001835-0s7ok4uw	2115	46	function	function	NN
cord-001835-0s7ok4uw	2115	47	.	.	.
cord-001835-0s7ok4uw	2116	1	The	the	DT
cord-001835-0s7ok4uw	2116	2	14	14	CD
cord-001835-0s7ok4uw	2116	3	-	-	SYM
cord-001835-0s7ok4uw	2116	4	3	3	CD
cord-001835-0s7ok4uw	2116	5	-	-	SYM
cord-001835-0s7ok4uw	2116	6	3	3	CD
cord-001835-0s7ok4uw	2116	7	protein	protein	NN
cord-001835-0s7ok4uw	2116	8	dimer	dimer	NN
cord-001835-0s7ok4uw	2116	9	interacts	interact	VBZ
cord-001835-0s7ok4uw	2116	10	with	with	IN
cord-001835-0s7ok4uw	2116	11	Pdc	Pdc	NNP
cord-001835-0s7ok4uw	2116	12	using	use	VBG
cord-001835-0s7ok4uw	2116	13	surfaces	surface	NNS
cord-001835-0s7ok4uw	2116	14	both	both	CC
cord-001835-0s7ok4uw	2116	15	inside	inside	IN
cord-001835-0s7ok4uw	2116	16	and	and	CC
cord-001835-0s7ok4uw	2116	17	outside	outside	IN
cord-001835-0s7ok4uw	2116	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2116	19	central	central	JJ
cord-001835-0s7ok4uw	2116	20	channel	channel	NN
cord-001835-0s7ok4uw	2116	21	.	.	.
cord-001835-0s7ok4uw	2117	1	The	the	DT
cord-001835-0s7ok4uw	2117	2	N	n	CD
cord-001835-0s7ok4uw	2117	3	-	-	HYPH
cord-001835-0s7ok4uw	2117	4	terminal	terminal	NN
cord-001835-0s7ok4uw	2117	5	domain	domain	NN
cord-001835-0s7ok4uw	2117	6	of	of	IN
cord-001835-0s7ok4uw	2117	7	Pdc	Pdc	NNP
cord-001835-0s7ok4uw	2117	8	,	,	,
cord-001835-0s7ok4uw	2117	9	where	where	WRB
cord-001835-0s7ok4uw	2117	10	both	both	DT
cord-001835-0s7ok4uw	2117	11	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	2117	12	sites	site	NNS
cord-001835-0s7ok4uw	2117	13	and	and	CC
cord-001835-0s7ok4uw	2117	14	the	the	DT
cord-001835-0s7ok4uw	2117	15	14	14	CD
cord-001835-0s7ok4uw	2117	16	-	-	SYM
cord-001835-0s7ok4uw	2117	17	3	3	CD
cord-001835-0s7ok4uw	2117	18	-	-	SYM
cord-001835-0s7ok4uw	2117	19	3	3	CD
cord-001835-0s7ok4uw	2117	20	binding	binding	NN
cord-001835-0s7ok4uw	2117	21	motifs	motif	NNS
cord-001835-0s7ok4uw	2117	22	are	be	VBP
cord-001835-0s7ok4uw	2117	23	located	locate	VBN
cord-001835-0s7ok4uw	2117	24	,	,	,
cord-001835-0s7ok4uw	2117	25	is	be	VBZ
cord-001835-0s7ok4uw	2117	26	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2117	27	disordered	disordered	JJ
cord-001835-0s7ok4uw	2117	28	protein	protein	NN
cord-001835-0s7ok4uw	2117	29	which	which	WDT
cord-001835-0s7ok4uw	2117	30	remains	remain	VBZ
cord-001835-0s7ok4uw	2117	31	likely	likely	RB
cord-001835-0s7ok4uw	2117	32	highly	highly	RB
cord-001835-0s7ok4uw	2117	33	flexible	flexible	JJ
cord-001835-0s7ok4uw	2117	34	when	when	WRB
cord-001835-0s7ok4uw	2117	35	bound	bind	VBN
cord-001835-0s7ok4uw	2117	36	to	to	IN
cord-001835-0s7ok4uw	2117	37	14	14	CD
cord-001835-0s7ok4uw	2117	38	-	-	SYM
cord-001835-0s7ok4uw	2117	39	3	3	CD
cord-001835-0s7ok4uw	2117	40	-	-	SYM
cord-001835-0s7ok4uw	2117	41	3	3	CD
cord-001835-0s7ok4uw	2117	42	indicating	indicate	VBG
cord-001835-0s7ok4uw	2117	43	the	the	DT
cord-001835-0s7ok4uw	2117	44	fuzzy	fuzzy	JJ
cord-001835-0s7ok4uw	2117	45	-	-	HYPH
cord-001835-0s7ok4uw	2117	46	like	like	JJ
cord-001835-0s7ok4uw	2117	47	character	character	NN
cord-001835-0s7ok4uw	2117	48	of	of	IN
cord-001835-0s7ok4uw	2117	49	this	this	DT
cord-001835-0s7ok4uw	2117	50	complex	complex	NN
cord-001835-0s7ok4uw	2117	51	.	.	.
cord-001835-0s7ok4uw	2118	1	In	in	IN
cord-001835-0s7ok4uw	2118	2	addition	addition	NN
cord-001835-0s7ok4uw	2118	3	,	,	,
cord-001835-0s7ok4uw	2118	4	it	-PRON-	PRP
cord-001835-0s7ok4uw	2118	5	has	have	VBZ
cord-001835-0s7ok4uw	2118	6	been	be	VBN
cord-001835-0s7ok4uw	2118	7	speculated	speculate	VBN
cord-001835-0s7ok4uw	2118	8	that	that	IN
cord-001835-0s7ok4uw	2118	9	the	the	DT
cord-001835-0s7ok4uw	2118	10	14	14	CD
cord-001835-0s7ok4uw	2118	11	-	-	SYM
cord-001835-0s7ok4uw	2118	12	3	3	CD
cord-001835-0s7ok4uw	2118	13	-	-	SYM
cord-001835-0s7ok4uw	2118	14	3	3	CD
cord-001835-0s7ok4uw	2118	15	protein	protein	NN
cord-001835-0s7ok4uw	2118	16	binding	binding	NN
cord-001835-0s7ok4uw	2118	17	decreases	decrease	VBZ
cord-001835-0s7ok4uw	2118	18	the	the	DT
cord-001835-0s7ok4uw	2118	19	rate	rate	NN
cord-001835-0s7ok4uw	2118	20	of	of	IN
cord-001835-0s7ok4uw	2118	21	Pdc	Pdc	NNP
cord-001835-0s7ok4uw	2118	22	dephosphorylation	dephosphorylation	NN
cord-001835-0s7ok4uw	2118	23	after	after	IN
cord-001835-0s7ok4uw	2118	24	a	a	DT
cord-001835-0s7ok4uw	2118	25	light	light	JJ
cord-001835-0s7ok4uw	2118	26	stimulus	stimulus	NN
cord-001835-0s7ok4uw	2118	27	through	through	IN
cord-001835-0s7ok4uw	2118	28	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2118	29	interaction	interaction	NN
cord-001835-0s7ok4uw	2118	30	with	with	IN
cord-001835-0s7ok4uw	2118	31	phosphorylated	phosphorylated	JJ
cord-001835-0s7ok4uw	2118	32	Ser54	Ser54	NNP
cord-001835-0s7ok4uw	2118	33	and	and	CC
cord-001835-0s7ok4uw	2118	34	Ser73	Ser73	NNP
cord-001835-0s7ok4uw	2118	35	,	,	,
cord-001835-0s7ok4uw	2118	36	thus	thus	RB
cord-001835-0s7ok4uw	2118	37	lengthening	lengthen	VBG
cord-001835-0s7ok4uw	2118	38	the	the	DT
cord-001835-0s7ok4uw	2118	39	time	time	NN
cord-001835-0s7ok4uw	2118	40	that	that	WDT
cord-001835-0s7ok4uw	2118	41	Pdc	Pdc	NNP
cord-001835-0s7ok4uw	2118	42	remains	remain	VBZ
cord-001835-0s7ok4uw	2118	43	phosphorylated	phosphorylate	VBN
cord-001835-0s7ok4uw	2118	44	after	after	IN
cord-001835-0s7ok4uw	2118	45	a	a	DT
cord-001835-0s7ok4uw	2118	46	light	light	JJ
cord-001835-0s7ok4uw	2118	47	exposure	exposure	NN
cord-001835-0s7ok4uw	2118	48	.	.	.
cord-001835-0s7ok4uw	2119	1	Pdc	Pdc	NNP
cord-001835-0s7ok4uw	2119	2	is	be	VBZ
cord-001835-0s7ok4uw	2119	3	dephosphorylated	dephosphorylate	VBN
cord-001835-0s7ok4uw	2119	4	in	in	IN
cord-001835-0s7ok4uw	2119	5	vivo	vivo	NN
cord-001835-0s7ok4uw	2119	6	by	by	IN
cord-001835-0s7ok4uw	2119	7	protein	protein	NN
cord-001835-0s7ok4uw	2119	8	phosphatases	phosphatase	NNS
cord-001835-0s7ok4uw	2119	9	known	know	VBN
cord-001835-0s7ok4uw	2119	10	to	to	TO
cord-001835-0s7ok4uw	2119	11	cause	cause	VB
cord-001835-0s7ok4uw	2119	12	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	2119	13	disease	disease	NN
cord-001835-0s7ok4uw	2119	14	in	in	IN
cord-001835-0s7ok4uw	2119	15	a	a	DT
cord-001835-0s7ok4uw	2119	16	polyglutamine	polyglutamine	JJ
cord-001835-0s7ok4uw	2119	17	-	-	HYPH
cord-001835-0s7ok4uw	2119	18	length	length	NN
cord-001835-0s7ok4uw	2119	19	dependent	dependent	JJ
cord-001835-0s7ok4uw	2119	20	manner	manner	NN
cord-001835-0s7ok4uw	2119	21	.	.	.
cord-001835-0s7ok4uw	2120	1	Despite	despite	IN
cord-001835-0s7ok4uw	2120	2	intense	intense	JJ
cord-001835-0s7ok4uw	2120	3	study	study	NN
cord-001835-0s7ok4uw	2120	4	,	,	,
cord-001835-0s7ok4uw	2120	5	the	the	DT
cord-001835-0s7ok4uw	2120	6	molecular	molecular	JJ
cord-001835-0s7ok4uw	2120	7	basis	basis	NN
cord-001835-0s7ok4uw	2120	8	of	of	IN
cord-001835-0s7ok4uw	2120	9	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2120	10	toxicity	toxicity	NN
cord-001835-0s7ok4uw	2120	11	in	in	IN
cord-001835-0s7ok4uw	2120	12	HD	hd	NN
cord-001835-0s7ok4uw	2120	13	or	or	CC
cord-001835-0s7ok4uw	2120	14	any	any	DT
cord-001835-0s7ok4uw	2120	15	of	of	IN
cord-001835-0s7ok4uw	2120	16	the	the	DT
cord-001835-0s7ok4uw	2120	17	other	other	JJ
cord-001835-0s7ok4uw	2120	18	diseases	disease	NNS
cord-001835-0s7ok4uw	2120	19	has	have	VBZ
cord-001835-0s7ok4uw	2120	20	only	only	RB
cord-001835-0s7ok4uw	2120	21	partially	partially	RB
cord-001835-0s7ok4uw	2120	22	been	be	VBN
cord-001835-0s7ok4uw	2120	23	elucidated	elucidate	VBN
cord-001835-0s7ok4uw	2120	24	and	and	CC
cord-001835-0s7ok4uw	2120	25	potential	potential	JJ
cord-001835-0s7ok4uw	2120	26	routes	route	NNS
cord-001835-0s7ok4uw	2120	27	to	to	IN
cord-001835-0s7ok4uw	2120	28	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	2120	29	intervention	intervention	NN
cord-001835-0s7ok4uw	2120	30	are	be	VBP
cord-001835-0s7ok4uw	2120	31	sparse	sparse	JJ
cord-001835-0s7ok4uw	2120	32	.	.	.
cord-001835-0s7ok4uw	2121	1	The	the	DT
cord-001835-0s7ok4uw	2121	2	use	use	NN
cord-001835-0s7ok4uw	2121	3	of	of	IN
cord-001835-0s7ok4uw	2121	4	genetically	genetically	RB
cord-001835-0s7ok4uw	2121	5	tractable	tractable	JJ
cord-001835-0s7ok4uw	2121	6	model	model	NN
cord-001835-0s7ok4uw	2121	7	organisms	organism	NNS
cord-001835-0s7ok4uw	2121	8	to	to	TO
cord-001835-0s7ok4uw	2121	9	identify	identify	VB
cord-001835-0s7ok4uw	2121	10	the	the	DT
cord-001835-0s7ok4uw	2121	11	cellular	cellular	JJ
cord-001835-0s7ok4uw	2121	12	pathologies	pathology	NNS
cord-001835-0s7ok4uw	2121	13	caused	cause	VBN
cord-001835-0s7ok4uw	2121	14	by	by	IN
cord-001835-0s7ok4uw	2121	15	mutant	mutant	JJ
cord-001835-0s7ok4uw	2121	16	huntingtin	huntingtin	NNP
cord-001835-0s7ok4uw	2121	17	expression	expression	NN
cord-001835-0s7ok4uw	2121	18	is	be	VBZ
cord-001835-0s7ok4uw	2121	19	essential	essential	JJ
cord-001835-0s7ok4uw	2121	20	to	to	IN
cord-001835-0s7ok4uw	2121	21	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2121	22	understanding	understanding	NN
cord-001835-0s7ok4uw	2121	23	of	of	IN
cord-001835-0s7ok4uw	2121	24	the	the	DT
cord-001835-0s7ok4uw	2121	25	disease	disease	NN
cord-001835-0s7ok4uw	2121	26	pathology	pathology	NN
cord-001835-0s7ok4uw	2121	27	in	in	IN
cord-001835-0s7ok4uw	2121	28	humans	human	NNS
cord-001835-0s7ok4uw	2121	29	.	.	.
cord-001835-0s7ok4uw	2122	1	In	in	IN
cord-001835-0s7ok4uw	2122	2	eukaryotes	eukaryote	NNS
cord-001835-0s7ok4uw	2122	3	,	,	,
cord-001835-0s7ok4uw	2122	4	many	many	JJ
cord-001835-0s7ok4uw	2122	5	of	of	IN
cord-001835-0s7ok4uw	2122	6	the	the	DT
cord-001835-0s7ok4uw	2122	7	protein	protein	NN
cord-001835-0s7ok4uw	2122	8	folding	fold	VBG
cord-001835-0s7ok4uw	2122	9	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	2122	10	pathways	pathway	NNS
cord-001835-0s7ok4uw	2122	11	are	be	VBP
cord-001835-0s7ok4uw	2123	1	highly	highly	RB
cord-001835-0s7ok4uw	2123	2	conserved	conserved	JJ
cord-001835-0s7ok4uw	2123	3	and	and	CC
cord-001835-0s7ok4uw	2123	4	yeast	yeast	NN
cord-001835-0s7ok4uw	2123	5	cells	cell	NNS
cord-001835-0s7ok4uw	2123	6	expressing	express	VBG
cord-001835-0s7ok4uw	2123	7	a	a	DT
cord-001835-0s7ok4uw	2123	8	glutamine	glutamine	NN
cord-001835-0s7ok4uw	2123	9	-	-	HYPH
cord-001835-0s7ok4uw	2123	10	expanded	expand	VBN
cord-001835-0s7ok4uw	2123	11	fragment	fragment	NN
cord-001835-0s7ok4uw	2123	12	of	of	IN
cord-001835-0s7ok4uw	2123	13	huntingtin	huntingtin	NNPS
cord-001835-0s7ok4uw	2123	14	exon	exon	NN
cord-001835-0s7ok4uw	2123	15	1	1	CD
cord-001835-0s7ok4uw	2123	16	exhibit	exhibit	NN
cord-001835-0s7ok4uw	2123	17	a	a	DT
cord-001835-0s7ok4uw	2123	18	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2123	19	length	length	NN
cord-001835-0s7ok4uw	2123	20	-	-	HYPH
cord-001835-0s7ok4uw	2123	21	dependent	dependent	JJ
cord-001835-0s7ok4uw	2123	22	toxicity	toxicity	NN
cord-001835-0s7ok4uw	2123	23	that	that	WDT
cord-001835-0s7ok4uw	2123	24	recapitulates	recapitulate	VBZ
cord-001835-0s7ok4uw	2123	25	many	many	JJ
cord-001835-0s7ok4uw	2123	26	of	of	IN
cord-001835-0s7ok4uw	2123	27	the	the	DT
cord-001835-0s7ok4uw	2123	28	basic	basic	JJ
cord-001835-0s7ok4uw	2123	29	protein	protein	NN
cord-001835-0s7ok4uw	2123	30	folding	folding	NN
cord-001835-0s7ok4uw	2123	31	defects	defect	NNS
cord-001835-0s7ok4uw	2123	32	associated	associate	VBN
cord-001835-0s7ok4uw	2123	33	with	with	IN
cord-001835-0s7ok4uw	2123	34	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2123	35	diseases	disease	NNS
cord-001835-0s7ok4uw	2123	36	in	in	IN
cord-001835-0s7ok4uw	2123	37	neurons	neuron	NNS
cord-001835-0s7ok4uw	2123	38	.	.	.
cord-001835-0s7ok4uw	2124	1	Taking	take	VBG
cord-001835-0s7ok4uw	2124	2	an	an	DT
cord-001835-0s7ok4uw	2124	3	unbiased	unbiased	JJ
cord-001835-0s7ok4uw	2124	4	approach	approach	NN
cord-001835-0s7ok4uw	2124	5	,	,	,
cord-001835-0s7ok4uw	2124	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	2124	7	screened	screen	VBD
cord-001835-0s7ok4uw	2124	8	an	an	DT
cord-001835-0s7ok4uw	2124	9	overexpression	overexpression	NN
cord-001835-0s7ok4uw	2124	10	library	library	NN
cord-001835-0s7ok4uw	2124	11	of	of	IN
cord-001835-0s7ok4uw	2124	12	the	the	DT
cord-001835-0s7ok4uw	2124	13	entire	entire	JJ
cord-001835-0s7ok4uw	2124	14	yeast	yeast	NN
cord-001835-0s7ok4uw	2124	15	genome	genome	NN
cord-001835-0s7ok4uw	2124	16	for	for	IN
cord-001835-0s7ok4uw	2124	17	suppressors	suppressor	NNS
cord-001835-0s7ok4uw	2124	18	and	and	CC
cord-001835-0s7ok4uw	2124	19	enhancers	enhancer	NNS
cord-001835-0s7ok4uw	2124	20	of	of	IN
cord-001835-0s7ok4uw	2124	21	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2124	22	toxicity	toxicity	NN
cord-001835-0s7ok4uw	2124	23	and	and	CC
cord-001835-0s7ok4uw	2124	24	identified	identify	VBD
cord-001835-0s7ok4uw	2124	25	seven	seven	CD
cord-001835-0s7ok4uw	2124	26	proteins	protein	NNS
cord-001835-0s7ok4uw	2124	27	with	with	IN
cord-001835-0s7ok4uw	2124	28	prion	prion	NN
cord-001835-0s7ok4uw	2124	29	-	-	HYPH
cord-001835-0s7ok4uw	2124	30	like	like	JJ
cord-001835-0s7ok4uw	2124	31	,	,	,
cord-001835-0s7ok4uw	2124	32	Q	q	NN
cord-001835-0s7ok4uw	2124	33	-	-	HYPH
cord-001835-0s7ok4uw	2124	34	rich	rich	JJ
cord-001835-0s7ok4uw	2124	35	domains	domain	NNS
cord-001835-0s7ok4uw	2124	36	that	that	WDT
cord-001835-0s7ok4uw	2124	37	are	be	VBP
cord-001835-0s7ok4uw	2124	38	strong	strong	JJ
cord-001835-0s7ok4uw	2124	39	suppressors	suppressor	NNS
cord-001835-0s7ok4uw	2124	40	in	in	IN
cord-001835-0s7ok4uw	2124	41	yeast	yeast	NN
cord-001835-0s7ok4uw	2124	42	.	.	.
cord-001835-0s7ok4uw	2125	1	Intriguingly	intriguingly	RB
cord-001835-0s7ok4uw	2125	2	,	,	,
cord-001835-0s7ok4uw	2125	3	the	the	DT
cord-001835-0s7ok4uw	2125	4	Q	q	NN
cord-001835-0s7ok4uw	2125	5	-	-	HYPH
cord-001835-0s7ok4uw	2125	6	rich	rich	JJ
cord-001835-0s7ok4uw	2125	7	domains	domain	NNS
cord-001835-0s7ok4uw	2125	8	of	of	IN
cord-001835-0s7ok4uw	2125	9	these	these	DT
cord-001835-0s7ok4uw	2125	10	proteins	protein	NNS
cord-001835-0s7ok4uw	2125	11	,	,	,
cord-001835-0s7ok4uw	2125	12	and	and	CC
cord-001835-0s7ok4uw	2125	13	several	several	JJ
cord-001835-0s7ok4uw	2125	14	other	other	JJ
cord-001835-0s7ok4uw	2125	15	Q	q	NN
cord-001835-0s7ok4uw	2125	16	-	-	HYPH
cord-001835-0s7ok4uw	2125	17	rich	rich	JJ
cord-001835-0s7ok4uw	2125	18	domains	domain	NNS
cord-001835-0s7ok4uw	2125	19	,	,	,
cord-001835-0s7ok4uw	2125	20	suppress	suppress	VB
cord-001835-0s7ok4uw	2125	21	toxicity	toxicity	NN
cord-001835-0s7ok4uw	2125	22	when	when	WRB
cord-001835-0s7ok4uw	2125	23	expressed	express	VBN
cord-001835-0s7ok4uw	2125	24	in	in	IN
cord-001835-0s7ok4uw	2125	25	isolation	isolation	NN
cord-001835-0s7ok4uw	2125	26	.	.	.
cord-001835-0s7ok4uw	2126	1	These	these	DT
cord-001835-0s7ok4uw	2126	2	suppressors	suppressor	NNS
cord-001835-0s7ok4uw	2126	3	are	be	VBP
cord-001835-0s7ok4uw	2126	4	also	also	RB
cord-001835-0s7ok4uw	2126	5	efficacious	efficacious	JJ
cord-001835-0s7ok4uw	2126	6	in	in	IN
cord-001835-0s7ok4uw	2126	7	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	2126	8	cells	cell	NNS
cord-001835-0s7ok4uw	2126	9	and	and	CC
cord-001835-0s7ok4uw	2126	10	,	,	,
cord-001835-0s7ok4uw	2126	11	strikingly	strikingly	RB
cord-001835-0s7ok4uw	2126	12	,	,	,
cord-001835-0s7ok4uw	2126	13	one	one	CD
cord-001835-0s7ok4uw	2126	14	suppressor	suppressor	NN
cord-001835-0s7ok4uw	2126	15	was	be	VBD
cord-001835-0s7ok4uw	2126	16	independently	independently	RB
cord-001835-0s7ok4uw	2126	17	shown	show	VBN
cord-001835-0s7ok4uw	2126	18	to	to	TO
cord-001835-0s7ok4uw	2126	19	alleviate	alleviate	VB
cord-001835-0s7ok4uw	2126	20	polyQ	polyQ	NNP
cord-001835-0s7ok4uw	2126	21	-	-	HYPH
cord-001835-0s7ok4uw	2126	22	expanded	expand	VBN
cord-001835-0s7ok4uw	2126	23	ataxin-3	ataxin-3	NN
cord-001835-0s7ok4uw	2126	24	toxicity	toxicity	NN
cord-001835-0s7ok4uw	2126	25	in	in	IN
cord-001835-0s7ok4uw	2126	26	a	a	DT
cord-001835-0s7ok4uw	2126	27	Drosophila	drosophila	JJ
cord-001835-0s7ok4uw	2126	28	model	model	NN
cord-001835-0s7ok4uw	2126	29	.	.	.
cord-001835-0s7ok4uw	2127	1	In	in	IN
cord-001835-0s7ok4uw	2127	2	yeast	yeast	NN
cord-001835-0s7ok4uw	2127	3	,	,	,
cord-001835-0s7ok4uw	2127	4	the	the	DT
cord-001835-0s7ok4uw	2127	5	suppressors	suppressor	NNS
cord-001835-0s7ok4uw	2127	6	co	co	VBP
cord-001835-0s7ok4uw	2127	7	-	-	VBN
cord-001835-0s7ok4uw	2127	8	aggregated	aggregated	JJ
cord-001835-0s7ok4uw	2128	1	with	with	IN
cord-001835-0s7ok4uw	2128	2	an	an	DT
cord-001835-0s7ok4uw	2128	3	otherwise	otherwise	RB
cord-001835-0s7ok4uw	2128	4	highly	highly	RB
cord-001835-0s7ok4uw	2128	5	toxic	toxic	JJ
cord-001835-0s7ok4uw	2128	6	103glutamine	103glutamine	NN
cord-001835-0s7ok4uw	2128	7	expanded	expand	VBD
cord-001835-0s7ok4uw	2128	8	huntingtin	huntingtin	NN
cord-001835-0s7ok4uw	2128	9	exon	exon	NN
cord-001835-0s7ok4uw	2128	10	1	1	CD
cord-001835-0s7ok4uw	2128	11	protein	protein	NN
cord-001835-0s7ok4uw	2128	12	(	(	-LRB-
cord-001835-0s7ok4uw	2128	13	Htt103Q	Htt103Q	NNP
cord-001835-0s7ok4uw	2128	14	)	)	-RRB-
cord-001835-0s7ok4uw	2128	15	,	,	,
cord-001835-0s7ok4uw	2128	16	resulting	result	VBG
cord-001835-0s7ok4uw	2128	17	in	in	IN
cord-001835-0s7ok4uw	2128	18	a	a	DT
cord-001835-0s7ok4uw	2128	19	non	non	JJ
cord-001835-0s7ok4uw	2128	20	-	-	JJ
cord-001835-0s7ok4uw	2128	21	toxic	toxic	JJ
cord-001835-0s7ok4uw	2128	22	aggregate	aggregate	NN
cord-001835-0s7ok4uw	2128	23	and	and	CC
cord-001835-0s7ok4uw	2128	24	eliminating	eliminate	VBG
cord-001835-0s7ok4uw	2128	25	populations	population	NNS
cord-001835-0s7ok4uw	2128	26	of	of	IN
cord-001835-0s7ok4uw	2128	27	diffusible	diffusible	JJ
cord-001835-0s7ok4uw	2128	28	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2128	29	species	specie	NNS
cord-001835-0s7ok4uw	2128	30	.	.	.
cord-001835-0s7ok4uw	2129	1	Using	use	VBG
cord-001835-0s7ok4uw	2129	2	a	a	DT
cord-001835-0s7ok4uw	2129	3	transcriptional	transcriptional	JJ
cord-001835-0s7ok4uw	2129	4	sensor	sensor	NN
cord-001835-0s7ok4uw	2129	5	for	for	IN
cord-001835-0s7ok4uw	2129	6	protein	protein	NN
cord-001835-0s7ok4uw	2129	7	coaggregation	coaggregation	NN
cord-001835-0s7ok4uw	2129	8	,	,	,
cord-001835-0s7ok4uw	2129	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	2129	10	determined	determine	VBD
cord-001835-0s7ok4uw	2129	11	that	that	IN
cord-001835-0s7ok4uw	2129	12	yeast	yeast	NN
cord-001835-0s7ok4uw	2129	13	and	and	CC
cord-001835-0s7ok4uw	2129	14	human	human	JJ
cord-001835-0s7ok4uw	2129	15	proteins	protein	NNS
cord-001835-0s7ok4uw	2129	16	that	that	WDT
cord-001835-0s7ok4uw	2129	17	normally	normally	RB
cord-001835-0s7ok4uw	2129	18	co	co	VBD
cord-001835-0s7ok4uw	2129	19	-	-	VBN
cord-001835-0s7ok4uw	2129	20	aggregated	aggregate	VBN
cord-001835-0s7ok4uw	2129	21	with	with	IN
cord-001835-0s7ok4uw	2129	22	Htt103Q	Htt103Q	NNP
cord-001835-0s7ok4uw	2129	23	did	do	VBD
cord-001835-0s7ok4uw	2129	24	not	not	RB
cord-001835-0s7ok4uw	2129	25	co	co	VB
cord-001835-0s7ok4uw	2129	26	-	-	VB
cord-001835-0s7ok4uw	2129	27	aggregate	aggregate	VB
cord-001835-0s7ok4uw	2129	28	with	with	IN
cord-001835-0s7ok4uw	2129	29	these	these	DT
cord-001835-0s7ok4uw	2129	30	hetero	hetero	NNS
cord-001835-0s7ok4uw	2129	31	-	-	HYPH
cord-001835-0s7ok4uw	2129	32	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	2129	33	.	.	.
cord-001835-0s7ok4uw	2130	1	Thus	thus	RB
cord-001835-0s7ok4uw	2130	2	,	,	,
cord-001835-0s7ok4uw	2130	3	these	these	DT
cord-001835-0s7ok4uw	2130	4	Q	q	NN
cord-001835-0s7ok4uw	2130	5	-	-	HYPH
cord-001835-0s7ok4uw	2130	6	rich	rich	JJ
cord-001835-0s7ok4uw	2130	7	domains	domain	NNS
cord-001835-0s7ok4uw	2130	8	may	may	MD
cord-001835-0s7ok4uw	2130	9	suppress	suppress	VB
cord-001835-0s7ok4uw	2130	10	Htt103Q	htt103q	JJ
cord-001835-0s7ok4uw	2130	11	toxicity	toxicity	NN
cord-001835-0s7ok4uw	2130	12	by	by	IN
cord-001835-0s7ok4uw	2130	13	two	two	CD
cord-001835-0s7ok4uw	2130	14	complementary	complementary	JJ
cord-001835-0s7ok4uw	2130	15	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	2130	16	:	:	:
cord-001835-0s7ok4uw	2130	17	trapping	trap	VBG
cord-001835-0s7ok4uw	2130	18	potentially	potentially	RB
cord-001835-0s7ok4uw	2130	19	toxic	toxic	JJ
cord-001835-0s7ok4uw	2130	20	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2130	21	in	in	IN
cord-001835-0s7ok4uw	2130	22	larger	large	JJR
cord-001835-0s7ok4uw	2130	23	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	2130	24	and	and	CC
cord-001835-0s7ok4uw	2130	25	by	by	IN
cord-001835-0s7ok4uw	2130	26	limiting	limit	VBG
cord-001835-0s7ok4uw	2130	27	the	the	DT
cord-001835-0s7ok4uw	2130	28	interactome	interactome	NNP
cord-001835-0s7ok4uw	2130	29	of	of	IN
cord-001835-0s7ok4uw	2130	30	the	the	DT
cord-001835-0s7ok4uw	2130	31	larger	large	JJR
cord-001835-0s7ok4uw	2130	32	Htt103Q	Htt103Q	NNP
cord-001835-0s7ok4uw	2130	33	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	2130	34	.	.	.
cord-001835-0s7ok4uw	2131	1	Structuring	structuring	NN
cord-001835-0s7ok4uw	2131	2	disorder	disorder	NN
cord-001835-0s7ok4uw	2131	3	:	:	:
cord-001835-0s7ok4uw	2132	1	the	the	DT
cord-001835-0s7ok4uw	2132	2	case	case	NN
cord-001835-0s7ok4uw	2132	3	of	of	IN
cord-001835-0s7ok4uw	2132	4	the	the	DT
cord-001835-0s7ok4uw	2132	5	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2132	6	disordered	disordered	JJ
cord-001835-0s7ok4uw	2132	7	Unique	unique	JJ
cord-001835-0s7ok4uw	2132	8	domain	domain	NN
cord-001835-0s7ok4uw	2132	9	of	of	IN
cord-001835-0s7ok4uw	2132	10	c	c	NNP
cord-001835-0s7ok4uw	2132	11	-	-	HYPH
cord-001835-0s7ok4uw	2132	12	Src	Src	NNP
cord-001835-0s7ok4uw	2132	13	Mariano	Mariano	NNP
cord-001835-0s7ok4uw	2132	14	Maffei	Maffei	NNP
cord-001835-0s7ok4uw	2132	15	1	1	CD
cord-001835-0s7ok4uw	2132	16	1	1	CD
cord-001835-0s7ok4uw	2132	17	About	about	RB
cord-001835-0s7ok4uw	2132	18	two	two	CD
cord-001835-0s7ok4uw	2132	19	thirds	third	NNS
cord-001835-0s7ok4uw	2132	20	of	of	IN
cord-001835-0s7ok4uw	2132	21	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	2132	22	proteins	protein	NNS
cord-001835-0s7ok4uw	2132	23	contain	contain	VBP
cord-001835-0s7ok4uw	2132	24	large	large	JJ
cord-001835-0s7ok4uw	2132	25	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2132	26	disordered	disordered	JJ
cord-001835-0s7ok4uw	2132	27	regions	region	NNS
cord-001835-0s7ok4uw	2132	28	.	.	.
cord-001835-0s7ok4uw	2133	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	2133	2	represent	represent	VBP
cord-001835-0s7ok4uw	2133	3	a	a	DT
cord-001835-0s7ok4uw	2133	4	change	change	NN
cord-001835-0s7ok4uw	2133	5	of	of	IN
cord-001835-0s7ok4uw	2133	6	paradigm	paradigm	NN
cord-001835-0s7ok4uw	2133	7	from	from	IN
cord-001835-0s7ok4uw	2133	8	"	"	``
cord-001835-0s7ok4uw	2133	9	structure	structure	NN
cord-001835-0s7ok4uw	2133	10	-	-	HYPH
cord-001835-0s7ok4uw	2133	11	function	function	NN
cord-001835-0s7ok4uw	2133	12	"	"	''
cord-001835-0s7ok4uw	2133	13	to	to	IN
cord-001835-0s7ok4uw	2133	14	"	"	``
cord-001835-0s7ok4uw	2133	15	information	information	NN
cord-001835-0s7ok4uw	2133	16	-	-	HYPH
cord-001835-0s7ok4uw	2133	17	function	function	NN
cord-001835-0s7ok4uw	2133	18	"	"	''
cord-001835-0s7ok4uw	2133	19	(	(	-LRB-
cord-001835-0s7ok4uw	2133	20	Uversky	Uversky	NNP
cord-001835-0s7ok4uw	2133	21	,	,	,
cord-001835-0s7ok4uw	2133	22	2011	2011	CD
cord-001835-0s7ok4uw	2133	23	;	;	:
cord-001835-0s7ok4uw	2133	24	Babu	Babu	NNP
cord-001835-0s7ok4uw	2133	25	et	et	NNP
cord-001835-0s7ok4uw	2133	26	al	al	NNP
cord-001835-0s7ok4uw	2133	27	.	.	NNP
cord-001835-0s7ok4uw	2133	28	,	,	,
cord-001835-0s7ok4uw	2133	29	2011	2011	CD
cord-001835-0s7ok4uw	2133	30	)	)	-RRB-
cord-001835-0s7ok4uw	2133	31	.	.	.
cord-001835-0s7ok4uw	2134	1	Structured	structured	JJ
cord-001835-0s7ok4uw	2134	2	proteins	protein	NNS
cord-001835-0s7ok4uw	2134	3	are	be	VBP
cord-001835-0s7ok4uw	2134	4	information	information	NN
cord-001835-0s7ok4uw	2134	5	rich	rich	JJ
cord-001835-0s7ok4uw	2134	6	,	,	,
cord-001835-0s7ok4uw	2134	7	but	but	CC
cord-001835-0s7ok4uw	2134	8	the	the	DT
cord-001835-0s7ok4uw	2134	9	current	current	JJ
cord-001835-0s7ok4uw	2134	10	challenge	challenge	NN
cord-001835-0s7ok4uw	2134	11	is	be	VBZ
cord-001835-0s7ok4uw	2134	12	to	to	TO
cord-001835-0s7ok4uw	2134	13	discover	discover	VB
cord-001835-0s7ok4uw	2134	14	how	how	WRB
cord-001835-0s7ok4uw	2134	15	information	information	NN
cord-001835-0s7ok4uw	2134	16	is	be	VBZ
cord-001835-0s7ok4uw	2134	17	stored	store	VBN
cord-001835-0s7ok4uw	2134	18	in	in	IN
cord-001835-0s7ok4uw	2134	19	disordered	disordered	JJ
cord-001835-0s7ok4uw	2134	20	protein	protein	NN
cord-001835-0s7ok4uw	2134	21	.	.	.
cord-001835-0s7ok4uw	2135	1	Regulation	regulation	NN
cord-001835-0s7ok4uw	2135	2	of	of	IN
cord-001835-0s7ok4uw	2135	3	c	c	NNP
cord-001835-0s7ok4uw	2135	4	-	-	HYPH
cord-001835-0s7ok4uw	2135	5	Src	Src	NNP
cord-001835-0s7ok4uw	2135	6	activity	activity	NN
cord-001835-0s7ok4uw	2135	7	,	,	,
cord-001835-0s7ok4uw	2135	8	the	the	DT
cord-001835-0s7ok4uw	2135	9	first	first	RB
cord-001835-0s7ok4uw	2135	10	discovered	discover	VBN
cord-001835-0s7ok4uw	2135	11	oncoprotein	oncoprotein	NNP
cord-001835-0s7ok4uw	2135	12	,	,	,
cord-001835-0s7ok4uw	2135	13	by	by	IN
cord-001835-0s7ok4uw	2135	14	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2135	15	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2135	16	disordered	disordered	JJ
cord-001835-0s7ok4uw	2135	17	N	n	CD
cord-001835-0s7ok4uw	2135	18	-	-	HYPH
cord-001835-0s7ok4uw	2135	19	terminal	terminal	NN
cord-001835-0s7ok4uw	2135	20	region	region	NN
cord-001835-0s7ok4uw	2135	21	has	have	VBZ
cord-001835-0s7ok4uw	2135	22	been	be	VBN
cord-001835-0s7ok4uw	2135	23	recently	recently	RB
cord-001835-0s7ok4uw	2135	24	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	2135	25	(	(	-LRB-
cord-001835-0s7ok4uw	2135	26	Perez	Perez	NNP
cord-001835-0s7ok4uw	2135	27	et	et	NNP
cord-001835-0s7ok4uw	2135	28	al	al	NNP
cord-001835-0s7ok4uw	2135	29	.	.	NNP
cord-001835-0s7ok4uw	2135	30	,	,	,
cord-001835-0s7ok4uw	2135	31	2013	2013	CD
cord-001835-0s7ok4uw	2135	32	)	)	-RRB-
cord-001835-0s7ok4uw	2135	33	.	.	.
cord-001835-0s7ok4uw	2136	1	Functional	functional	JJ
cord-001835-0s7ok4uw	2136	2	studies	study	NNS
cord-001835-0s7ok4uw	2136	3	have	have	VBP
cord-001835-0s7ok4uw	2136	4	revealed	reveal	VBN
cord-001835-0s7ok4uw	2136	5	that	that	IN
cord-001835-0s7ok4uw	2136	6	mutations	mutation	NNS
cord-001835-0s7ok4uw	2136	7	in	in	IN
cord-001835-0s7ok4uw	2136	8	the	the	DT
cord-001835-0s7ok4uw	2136	9	ULBR	ULBR	NNP
cord-001835-0s7ok4uw	2136	10	cause	cause	VB
cord-001835-0s7ok4uw	2136	11	strong	strong	JJ
cord-001835-0s7ok4uw	2136	12	phenotypes	phenotype	NNS
cord-001835-0s7ok4uw	2136	13	when	when	WRB
cord-001835-0s7ok4uw	2136	14	introduced	introduce	VBN
cord-001835-0s7ok4uw	2136	15	in	in	IN
cord-001835-0s7ok4uw	2136	16	fulllength	fulllength	NN
cord-001835-0s7ok4uw	2136	17	c	c	NNP
cord-001835-0s7ok4uw	2136	18	-	-	:
cord-001835-0s7ok4uw	2136	19	Src	Src	NNP
cord-001835-0s7ok4uw	2136	20	and	and	CC
cord-001835-0s7ok4uw	2136	21	expressed	express	VBD
cord-001835-0s7ok4uw	2136	22	in	in	IN
cord-001835-0s7ok4uw	2136	23	Xenopus	Xenopus	NNP
cord-001835-0s7ok4uw	2136	24	laevis	laevi	NNS
cord-001835-0s7ok4uw	2136	25	oocytes	oocyte	NNS
cord-001835-0s7ok4uw	2136	26	(	(	-LRB-
cord-001835-0s7ok4uw	2136	27	Perez	Perez	NNP
cord-001835-0s7ok4uw	2136	28	et	et	NNP
cord-001835-0s7ok4uw	2136	29	al	al	NNP
cord-001835-0s7ok4uw	2136	30	.	.	NNP
cord-001835-0s7ok4uw	2136	31	,	,	,
cord-001835-0s7ok4uw	2136	32	2013	2013	CD
cord-001835-0s7ok4uw	2136	33	)	)	-RRB-
cord-001835-0s7ok4uw	2136	34	or	or	CC
cord-001835-0s7ok4uw	2136	35	in	in	IN
cord-001835-0s7ok4uw	2136	36	human	human	JJ
cord-001835-0s7ok4uw	2136	37	SW620	SW620	NNP
cord-001835-0s7ok4uw	2136	38	colorectal	colorectal	JJ
cord-001835-0s7ok4uw	2136	39	cancer	cancer	NN
cord-001835-0s7ok4uw	2136	40	cells	cell	NNS
cord-001835-0s7ok4uw	2136	41	(	(	-LRB-
cord-001835-0s7ok4uw	2136	42	unpublished	unpublished	JJ
cord-001835-0s7ok4uw	2136	43	)	)	-RRB-
cord-001835-0s7ok4uw	2136	44	.	.	.
cord-001835-0s7ok4uw	2137	1	However	however	RB
cord-001835-0s7ok4uw	2137	2	,	,	,
cord-001835-0s7ok4uw	2137	3	the	the	DT
cord-001835-0s7ok4uw	2137	4	connection	connection	NN
cord-001835-0s7ok4uw	2137	5	with	with	IN
cord-001835-0s7ok4uw	2137	6	the	the	DT
cord-001835-0s7ok4uw	2137	7	classical	classical	JJ
cord-001835-0s7ok4uw	2137	8	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	2137	9	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	2137	10	is	be	VBZ
cord-001835-0s7ok4uw	2137	11	still	still	RB
cord-001835-0s7ok4uw	2137	12	missing	miss	VBG
cord-001835-0s7ok4uw	2137	13	.	.	.
cord-001835-0s7ok4uw	2138	1	c	c	LS
cord-001835-0s7ok4uw	2138	2	-	-	HYPH
cord-001835-0s7ok4uw	2138	3	Src	Src	NNP
cord-001835-0s7ok4uw	2138	4	domain	domain	NN
cord-001835-0s7ok4uw	2138	5	structure	structure	NN
cord-001835-0s7ok4uw	2138	6	consists	consist	VBZ
cord-001835-0s7ok4uw	2138	7	of	of	IN
cord-001835-0s7ok4uw	2138	8	four	four	CD
cord-001835-0s7ok4uw	2138	9	"	"	``
cord-001835-0s7ok4uw	2138	10	Src	src	NN
cord-001835-0s7ok4uw	2138	11	-	-	HYPH
cord-001835-0s7ok4uw	2138	12	homology	homology	NN
cord-001835-0s7ok4uw	2138	13	"	"	''
cord-001835-0s7ok4uw	2138	14	domains	domain	NNS
cord-001835-0s7ok4uw	2138	15	:	:	:
cord-001835-0s7ok4uw	2138	16	SH4	SH4	NNP
cord-001835-0s7ok4uw	2138	17	,	,	,
cord-001835-0s7ok4uw	2138	18	SH3	SH3	NNP
cord-001835-0s7ok4uw	2138	19	,	,	,
cord-001835-0s7ok4uw	2138	20	SH2	SH2	NNP
cord-001835-0s7ok4uw	2138	21	and	and	CC
cord-001835-0s7ok4uw	2138	22	SH1	SH1	NNP
cord-001835-0s7ok4uw	2138	23	,	,	,
cord-001835-0s7ok4uw	2138	24	arranged	arrange	VBN
cord-001835-0s7ok4uw	2138	25	in	in	IN
cord-001835-0s7ok4uw	2138	26	this	this	DT
cord-001835-0s7ok4uw	2138	27	order	order	NN
cord-001835-0s7ok4uw	2138	28	from	from	IN
cord-001835-0s7ok4uw	2138	29	the	the	DT
cord-001835-0s7ok4uw	2138	30	N	N	NNP
cord-001835-0s7ok4uw	2138	31	-	-	HYPH
cord-001835-0s7ok4uw	2138	32	terminus	terminus	NN
cord-001835-0s7ok4uw	2138	33	to	to	IN
cord-001835-0s7ok4uw	2138	34	the	the	DT
cord-001835-0s7ok4uw	2138	35	C	C	NNP
cord-001835-0s7ok4uw	2138	36	-	-	HYPH
cord-001835-0s7ok4uw	2138	37	terminus	terminus	NN
cord-001835-0s7ok4uw	2138	38	,	,	,
cord-001835-0s7ok4uw	2138	39	with	with	IN
cord-001835-0s7ok4uw	2138	40	the	the	DT
cord-001835-0s7ok4uw	2138	41	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2138	42	disordered	disordered	JJ
cord-001835-0s7ok4uw	2138	43	"	"	``
cord-001835-0s7ok4uw	2138	44	Unique	unique	JJ
cord-001835-0s7ok4uw	2138	45	"	"	''
cord-001835-0s7ok4uw	2138	46	domain	domain	NN
cord-001835-0s7ok4uw	2138	47	separating	separate	VBG
cord-001835-0s7ok4uw	2138	48	the	the	DT
cord-001835-0s7ok4uw	2138	49	SH4	SH4	NNP
cord-001835-0s7ok4uw	2138	50	and	and	CC
cord-001835-0s7ok4uw	2138	51	SH3	SH3	NNP
cord-001835-0s7ok4uw	2138	52	domains	domain	NNS
cord-001835-0s7ok4uw	2138	53	.	.	.
cord-001835-0s7ok4uw	2139	1	Classically	classically	RB
cord-001835-0s7ok4uw	2139	2	,	,	,
cord-001835-0s7ok4uw	2139	3	the	the	DT
cord-001835-0s7ok4uw	2139	4	SH3	SH3	NNP
cord-001835-0s7ok4uw	2139	5	and	and	CC
cord-001835-0s7ok4uw	2139	6	SH2	SH2	NNP
cord-001835-0s7ok4uw	2139	7	domains	domain	NNS
cord-001835-0s7ok4uw	2139	8	are	be	VBP
cord-001835-0s7ok4uw	2139	9	involved	involve	VBN
cord-001835-0s7ok4uw	2139	10	in	in	IN
cord-001835-0s7ok4uw	2139	11	regulation	regulation	NN
cord-001835-0s7ok4uw	2139	12	and	and	CC
cord-001835-0s7ok4uw	2139	13	the	the	DT
cord-001835-0s7ok4uw	2139	14	SH4	SH4	NNP
cord-001835-0s7ok4uw	2139	15	domain	domain	NN
cord-001835-0s7ok4uw	2139	16	is	be	VBZ
cord-001835-0s7ok4uw	2139	17	the	the	DT
cord-001835-0s7ok4uw	2139	18	membrane	membrane	NN
cord-001835-0s7ok4uw	2139	19	anchoring	anchor	VBG
cord-001835-0s7ok4uw	2139	20	site	site	NN
cord-001835-0s7ok4uw	2139	21	.	.	.
cord-001835-0s7ok4uw	2140	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2140	2	will	will	MD
cord-001835-0s7ok4uw	2140	3	present	present	VB
cord-001835-0s7ok4uw	2140	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2140	5	recent	recent	JJ
cord-001835-0s7ok4uw	2140	6	results	result	NNS
cord-001835-0s7ok4uw	2140	7	showing	show	VBG
cord-001835-0s7ok4uw	2140	8	that	that	IN
cord-001835-0s7ok4uw	2140	9	the	the	DT
cord-001835-0s7ok4uw	2140	10	Unique	unique	JJ
cord-001835-0s7ok4uw	2140	11	domain	domain	NN
cord-001835-0s7ok4uw	2140	12	is	be	VBZ
cord-001835-0s7ok4uw	2140	13	part	part	NN
cord-001835-0s7ok4uw	2140	14	of	of	IN
cord-001835-0s7ok4uw	2140	15	a	a	DT
cord-001835-0s7ok4uw	2140	16	long	long	JJ
cord-001835-0s7ok4uw	2140	17	loop	loop	NN
cord-001835-0s7ok4uw	2140	18	closed	close	VBN
cord-001835-0s7ok4uw	2140	19	by	by	IN
cord-001835-0s7ok4uw	2140	20	the	the	DT
cord-001835-0s7ok4uw	2140	21	interaction	interaction	NN
cord-001835-0s7ok4uw	2140	22	of	of	IN
cord-001835-0s7ok4uw	2140	23	the	the	DT
cord-001835-0s7ok4uw	2140	24	SH4	SH4	NNP
cord-001835-0s7ok4uw	2140	25	and	and	CC
cord-001835-0s7ok4uw	2140	26	SH3	SH3	NNP
cord-001835-0s7ok4uw	2140	27	domains	domain	NNS
cord-001835-0s7ok4uw	2140	28	(	(	-LRB-
cord-001835-0s7ok4uw	2140	29	Maffei	Maffei	NNP
cord-001835-0s7ok4uw	2140	30	et	et	NNP
cord-001835-0s7ok4uw	2140	31	al	al	NNP
cord-001835-0s7ok4uw	2140	32	.	.	NNP
cord-001835-0s7ok4uw	2140	33	,	,	,
cord-001835-0s7ok4uw	2140	34	2015	2015	CD
cord-001835-0s7ok4uw	2140	35	)	)	-RRB-
cord-001835-0s7ok4uw	2140	36	.	.	.
cord-001835-0s7ok4uw	2141	1	The	the	DT
cord-001835-0s7ok4uw	2141	2	conformational	conformational	JJ
cord-001835-0s7ok4uw	2141	3	freedom	freedom	NN
cord-001835-0s7ok4uw	2141	4	of	of	IN
cord-001835-0s7ok4uw	2141	5	this	this	DT
cord-001835-0s7ok4uw	2141	6	disordered	disordered	JJ
cord-001835-0s7ok4uw	2141	7	region	region	NN
cord-001835-0s7ok4uw	2141	8	is	be	VBZ
cord-001835-0s7ok4uw	2141	9	further	further	RB
cord-001835-0s7ok4uw	2141	10	restricted	restrict	VBN
cord-001835-0s7ok4uw	2141	11	through	through	IN
cord-001835-0s7ok4uw	2141	12	direct	direct	JJ
cord-001835-0s7ok4uw	2141	13	contacts	contact	NNS
cord-001835-0s7ok4uw	2141	14	between	between	IN
cord-001835-0s7ok4uw	2141	15	the	the	DT
cord-001835-0s7ok4uw	2141	16	RT	rt	NN
cord-001835-0s7ok4uw	2141	17	-	-	HYPH
cord-001835-0s7ok4uw	2141	18	loop	loop	NN
cord-001835-0s7ok4uw	2141	19	of	of	IN
cord-001835-0s7ok4uw	2141	20	the	the	DT
cord-001835-0s7ok4uw	2141	21	SH3	SH3	NNP
cord-001835-0s7ok4uw	2141	22	domain	domain	NN
cord-001835-0s7ok4uw	2141	23	and	and	CC
cord-001835-0s7ok4uw	2141	24	,	,	,
cord-001835-0s7ok4uw	2141	25	primarily	primarily	RB
cord-001835-0s7ok4uw	2141	26	,	,	,
cord-001835-0s7ok4uw	2141	27	residues	residue	NNS
cord-001835-0s7ok4uw	2141	28	located	locate	VBN
cord-001835-0s7ok4uw	2141	29	within	within	IN
cord-001835-0s7ok4uw	2141	30	the	the	DT
cord-001835-0s7ok4uw	2141	31	recently	recently	RB
cord-001835-0s7ok4uw	2141	32	discovered	discover	VBN
cord-001835-0s7ok4uw	2141	33	Unique	unique	JJ
cord-001835-0s7ok4uw	2141	34	lipid	lipid	NN
cord-001835-0s7ok4uw	2141	35	binding	bind	VBG
cord-001835-0s7ok4uw	2141	36	region	region	NN
cord-001835-0s7ok4uw	2141	37	(	(	-LRB-
cord-001835-0s7ok4uw	2141	38	ULBR	ULBR	NNP
cord-001835-0s7ok4uw	2141	39	)	)	-RRB-
cord-001835-0s7ok4uw	2141	40	.	.	.
cord-001835-0s7ok4uw	2142	1	The	the	DT
cord-001835-0s7ok4uw	2142	2	interaction	interaction	NN
cord-001835-0s7ok4uw	2142	3	between	between	IN
cord-001835-0s7ok4uw	2142	4	the	the	DT
cord-001835-0s7ok4uw	2142	5	Unique	Unique	NNP
cord-001835-0s7ok4uw	2142	6	and	and	CC
cord-001835-0s7ok4uw	2142	7	SH3	SH3	NNP
cord-001835-0s7ok4uw	2142	8	domains	domain	NNS
cord-001835-0s7ok4uw	2142	9	is	be	VBZ
cord-001835-0s7ok4uw	2142	10	allosterically	allosterically	RB
cord-001835-0s7ok4uw	2142	11	modulated	modulate	VBN
cord-001835-0s7ok4uw	2142	12	by	by	IN
cord-001835-0s7ok4uw	2142	13	a	a	DT
cord-001835-0s7ok4uw	2142	14	poly	poly	JJ
cord-001835-0s7ok4uw	2142	15	-	-	HYPH
cord-001835-0s7ok4uw	2142	16	proline	proline	NN
cord-001835-0s7ok4uw	2142	17	ligand	ligand	NN
cord-001835-0s7ok4uw	2142	18	binding	bind	VBG
cord-001835-0s7ok4uw	2142	19	to	to	IN
cord-001835-0s7ok4uw	2142	20	the	the	DT
cord-001835-0s7ok4uw	2142	21	canonical	canonical	JJ
cord-001835-0s7ok4uw	2142	22	binding	binding	NN
cord-001835-0s7ok4uw	2142	23	site	site	NN
cord-001835-0s7ok4uw	2142	24	of	of	IN
cord-001835-0s7ok4uw	2142	25	the	the	DT
cord-001835-0s7ok4uw	2142	26	SH3	SH3	NNP
cord-001835-0s7ok4uw	2142	27	domain	domain	NN
cord-001835-0s7ok4uw	2142	28	(	(	-LRB-
cord-001835-0s7ok4uw	2142	29	Maffei	Maffei	NNP
cord-001835-0s7ok4uw	2142	30	et	et	NNP
cord-001835-0s7ok4uw	2142	31	al	al	NNP
cord-001835-0s7ok4uw	2142	32	.	.	NNP
cord-001835-0s7ok4uw	2142	33	,	,	,
cord-001835-0s7ok4uw	2142	34	2015	2015	CD
cord-001835-0s7ok4uw	2142	35	)	)	-RRB-
cord-001835-0s7ok4uw	2142	36	.	.	.
cord-001835-0s7ok4uw	2143	1	These	these	DT
cord-001835-0s7ok4uw	2143	2	results	result	NNS
cord-001835-0s7ok4uw	2143	3	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	2143	4	a	a	DT
cord-001835-0s7ok4uw	2143	5	direct	direct	JJ
cord-001835-0s7ok4uw	2143	6	connection	connection	NN
cord-001835-0s7ok4uw	2143	7	between	between	IN
cord-001835-0s7ok4uw	2143	8	classical	classical	JJ
cord-001835-0s7ok4uw	2143	9	c	c	NNP
cord-001835-0s7ok4uw	2143	10	-	-	HYPH
cord-001835-0s7ok4uw	2143	11	Src	Src	NNP
cord-001835-0s7ok4uw	2143	12	regulation	regulation	NN
cord-001835-0s7ok4uw	2143	13	involving	involve	VBG
cord-001835-0s7ok4uw	2143	14	the	the	DT
cord-001835-0s7ok4uw	2143	15	SH3	SH3	NNP
cord-001835-0s7ok4uw	2143	16	domain	domain	NN
cord-001835-0s7ok4uw	2143	17	and	and	CC
cord-001835-0s7ok4uw	2143	18	the	the	DT
cord-001835-0s7ok4uw	2143	19	new	new	JJ
cord-001835-0s7ok4uw	2143	20	regulation	regulation	NN
cord-001835-0s7ok4uw	2143	21	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	2143	22	involving	involve	VBG
cord-001835-0s7ok4uw	2143	23	the	the	DT
cord-001835-0s7ok4uw	2143	24	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2143	25	disordered	disordered	JJ
cord-001835-0s7ok4uw	2143	26	regions	region	NNS
cord-001835-0s7ok4uw	2143	27	and	and	CC
cord-001835-0s7ok4uw	2143	28	provide	provide	VB
cord-001835-0s7ok4uw	2143	29	new	new	JJ
cord-001835-0s7ok4uw	2143	30	evidence	evidence	NN
cord-001835-0s7ok4uw	2143	31	of	of	IN
cord-001835-0s7ok4uw	2143	32	the	the	DT
cord-001835-0s7ok4uw	2143	33	functional	functional	JJ
cord-001835-0s7ok4uw	2143	34	importance	importance	NN
cord-001835-0s7ok4uw	2143	35	and	and	CC
cord-001835-0s7ok4uw	2143	36	the	the	DT
cord-001835-0s7ok4uw	2143	37	underlying	underlying	JJ
cord-001835-0s7ok4uw	2143	38	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2143	39	behind	behind	IN
cord-001835-0s7ok4uw	2143	40	regulation	regulation	NN
cord-001835-0s7ok4uw	2143	41	of	of	IN
cord-001835-0s7ok4uw	2143	42	signalling	signal	VBG
cord-001835-0s7ok4uw	2143	43	pathways	pathway	NNS
cord-001835-0s7ok4uw	2143	44	by	by	IN
cord-001835-0s7ok4uw	2143	45	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2143	46	disordered	disordered	JJ
cord-001835-0s7ok4uw	2143	47	domains	domain	NNS
cord-001835-0s7ok4uw	2143	48	.	.	.
cord-001835-0s7ok4uw	2144	1	In	in	IN
cord-001835-0s7ok4uw	2144	2	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	2144	3	cells	cell	NNS
cord-001835-0s7ok4uw	2144	4	,	,	,
cord-001835-0s7ok4uw	2144	5	the	the	DT
cord-001835-0s7ok4uw	2144	6	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	2144	7	reassembly	reassembly	NN
cord-001835-0s7ok4uw	2144	8	and	and	CC
cord-001835-0s7ok4uw	2144	9	stacking	stack	VBG
cord-001835-0s7ok4uw	2144	10	proteins	protein	NNS
cord-001835-0s7ok4uw	2144	11	(	(	-LRB-
cord-001835-0s7ok4uw	2144	12	GRASP55	grasp55	VB
cord-001835-0s7ok4uw	2144	13	and	and	CC
cord-001835-0s7ok4uw	2144	14	GRASP65	GRASP65	NNP
cord-001835-0s7ok4uw	2144	15	)	)	-RRB-
cord-001835-0s7ok4uw	2144	16	are	be	VBP
cord-001835-0s7ok4uw	2144	17	involved	involve	VBN
cord-001835-0s7ok4uw	2144	18	in	in	IN
cord-001835-0s7ok4uw	2144	19	the	the	DT
cord-001835-0s7ok4uw	2144	20	stacking	stacking	NN
cord-001835-0s7ok4uw	2144	21	of	of	IN
cord-001835-0s7ok4uw	2144	22	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	2144	23	apparatus	apparatus	NN
cord-001835-0s7ok4uw	2144	24	cisternae	cisternae	NN
cord-001835-0s7ok4uw	2144	25	and	and	CC
cord-001835-0s7ok4uw	2144	26	in	in	IN
cord-001835-0s7ok4uw	2144	27	the	the	DT
cord-001835-0s7ok4uw	2144	28	formation	formation	NN
cord-001835-0s7ok4uw	2144	29	of	of	IN
cord-001835-0s7ok4uw	2144	30	the	the	DT
cord-001835-0s7ok4uw	2144	31	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	2144	32	ribbon	ribbon	NN
cord-001835-0s7ok4uw	2144	33	.	.	.
cord-001835-0s7ok4uw	2145	1	Since	since	IN
cord-001835-0s7ok4uw	2145	2	GRASPs	grasp	NNS
cord-001835-0s7ok4uw	2145	3	have	have	VBP
cord-001835-0s7ok4uw	2145	4	been	be	VBN
cord-001835-0s7ok4uw	2145	5	identified	identify	VBN
cord-001835-0s7ok4uw	2145	6	in	in	IN
cord-001835-0s7ok4uw	2145	7	many	many	JJ
cord-001835-0s7ok4uw	2145	8	organisms	organism	NNS
cord-001835-0s7ok4uw	2145	9	,	,	,
cord-001835-0s7ok4uw	2145	10	other	other	JJ
cord-001835-0s7ok4uw	2145	11	roles	role	NNS
cord-001835-0s7ok4uw	2145	12	for	for	IN
cord-001835-0s7ok4uw	2145	13	GRASPs	grasp	NNS
cord-001835-0s7ok4uw	2145	14	have	have	VBP
cord-001835-0s7ok4uw	2145	15	already	already	RB
cord-001835-0s7ok4uw	2145	16	been	be	VBN
cord-001835-0s7ok4uw	2145	17	pointed	point	VBN
cord-001835-0s7ok4uw	2145	18	out	out	RP
cord-001835-0s7ok4uw	2145	19	,	,	,
cord-001835-0s7ok4uw	2145	20	such	such	JJ
cord-001835-0s7ok4uw	2145	21	as	as	IN
cord-001835-0s7ok4uw	2145	22	chaperoning	chaperone	VBG
cord-001835-0s7ok4uw	2145	23	and	and	CC
cord-001835-0s7ok4uw	2145	24	transport	transport	NN
cord-001835-0s7ok4uw	2145	25	of	of	IN
cord-001835-0s7ok4uw	2145	26	other	other	JJ
cord-001835-0s7ok4uw	2145	27	proteins	protein	NNS
cord-001835-0s7ok4uw	2145	28	,	,	,
cord-001835-0s7ok4uw	2145	29	involvement	involvement	NN
cord-001835-0s7ok4uw	2145	30	in	in	IN
cord-001835-0s7ok4uw	2145	31	cell	cell	NN
cord-001835-0s7ok4uw	2145	32	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	2145	33	,	,	,
cord-001835-0s7ok4uw	2145	34	cell	cell	NN
cord-001835-0s7ok4uw	2145	35	migration	migration	NN
cord-001835-0s7ok4uw	2145	36	,	,	,
cord-001835-0s7ok4uw	2145	37	unconventional	unconventional	JJ
cord-001835-0s7ok4uw	2145	38	secretion	secretion	NN
cord-001835-0s7ok4uw	2145	39	,	,	,
cord-001835-0s7ok4uw	2145	40	and	and	CC
cord-001835-0s7ok4uw	2145	41	in	in	IN
cord-001835-0s7ok4uw	2145	42	mitosis	mitosis	NN
cord-001835-0s7ok4uw	2145	43	.	.	.
cord-001835-0s7ok4uw	2146	1	In	in	IN
cord-001835-0s7ok4uw	2146	2	Saccharomyces	Saccharomyces	NNP
cord-001835-0s7ok4uw	2146	3	cerevisiae	cerevisiae	NNS
cord-001835-0s7ok4uw	2146	4	,	,	,
cord-001835-0s7ok4uw	2146	5	it	-PRON-	PRP
cord-001835-0s7ok4uw	2146	6	is	be	VBZ
cord-001835-0s7ok4uw	2146	7	observed	observe	VBN
cord-001835-0s7ok4uw	2146	8	that	that	IN
cord-001835-0s7ok4uw	2146	9	only	only	RB
cord-001835-0s7ok4uw	2146	10	40	40	CD
cord-001835-0s7ok4uw	2146	11	%	%	NN
cord-001835-0s7ok4uw	2146	12	of	of	IN
cord-001835-0s7ok4uw	2146	13	the	the	DT
cord-001835-0s7ok4uw	2146	14	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	2146	15	cisternae	cisternae	NNP
cord-001835-0s7ok4uw	2146	16	are	be	VBP
cord-001835-0s7ok4uw	2146	17	in	in	IN
cord-001835-0s7ok4uw	2146	18	stacks	stack	NNS
cord-001835-0s7ok4uw	2146	19	and	and	CC
cord-001835-0s7ok4uw	2146	20	do	do	VBP
cord-001835-0s7ok4uw	2146	21	not	not	RB
cord-001835-0s7ok4uw	2146	22	form	form	VB
cord-001835-0s7ok4uw	2146	23	ribbon	ribbon	NN
cord-001835-0s7ok4uw	2146	24	structures	structure	NNS
cord-001835-0s7ok4uw	2146	25	.	.	.
cord-001835-0s7ok4uw	2147	1	This	this	DT
cord-001835-0s7ok4uw	2147	2	build	build	NN
cord-001835-0s7ok4uw	2147	3	yeast	yeast	NN
cord-001835-0s7ok4uw	2147	4	contains	contain	VBZ
cord-001835-0s7ok4uw	2147	5	a	a	DT
cord-001835-0s7ok4uw	2147	6	single	single	JJ
cord-001835-0s7ok4uw	2147	7	GRASP	grasp	NN
cord-001835-0s7ok4uw	2147	8	,	,	,
cord-001835-0s7ok4uw	2147	9	called	call	VBN
cord-001835-0s7ok4uw	2147	10	Grh1	Grh1	NNP
cord-001835-0s7ok4uw	2147	11	,	,	,
cord-001835-0s7ok4uw	2147	12	that	that	RB
cord-001835-0s7ok4uw	2147	13	is	be	VBZ
cord-001835-0s7ok4uw	2147	14	analogue	analogue	JJ
cord-001835-0s7ok4uw	2147	15	to	to	IN
cord-001835-0s7ok4uw	2147	16	GRASP65	GRASP65	NNP
cord-001835-0s7ok4uw	2147	17	.	.	.
cord-001835-0s7ok4uw	2148	1	The	the	DT
cord-001835-0s7ok4uw	2148	2	structural	structural	JJ
cord-001835-0s7ok4uw	2148	3	differences	difference	NNS
cord-001835-0s7ok4uw	2148	4	of	of	IN
cord-001835-0s7ok4uw	2148	5	the	the	DT
cord-001835-0s7ok4uw	2148	6	Golgi	Golgi	NNP
cord-001835-0s7ok4uw	2148	7	apparatus	apparatus	NN
cord-001835-0s7ok4uw	2148	8	and	and	CC
cord-001835-0s7ok4uw	2148	9	the	the	DT
cord-001835-0s7ok4uw	2148	10	functional	functional	JJ
cord-001835-0s7ok4uw	2148	11	repertoire	repertoire	NN
cord-001835-0s7ok4uw	2148	12	of	of	IN
cord-001835-0s7ok4uw	2148	13	GRASPs	grasp	NNS
cord-001835-0s7ok4uw	2148	14	suggest	suggest	VBP
cord-001835-0s7ok4uw	2148	15	a	a	DT
cord-001835-0s7ok4uw	2148	16	structural	structural	JJ
cord-001835-0s7ok4uw	2148	17	dynamic	dynamic	NN
cord-001835-0s7ok4uw	2148	18	of	of	IN
cord-001835-0s7ok4uw	2148	19	these	these	DT
cord-001835-0s7ok4uw	2148	20	proteins	protein	NNS
cord-001835-0s7ok4uw	2148	21	.	.	.
cord-001835-0s7ok4uw	2149	1	Here	here	RB
cord-001835-0s7ok4uw	2149	2	,	,	,
cord-001835-0s7ok4uw	2149	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2149	4	used	use	VBD
cord-001835-0s7ok4uw	2149	5	a	a	DT
cord-001835-0s7ok4uw	2149	6	combination	combination	NN
cord-001835-0s7ok4uw	2149	7	of	of	IN
cord-001835-0s7ok4uw	2149	8	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	2149	9	/	/	SYM
cord-001835-0s7ok4uw	2149	10	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	2149	11	methods	method	NNS
cord-001835-0s7ok4uw	2149	12	to	to	TO
cord-001835-0s7ok4uw	2149	13	investigate	investigate	VB
cord-001835-0s7ok4uw	2149	14	the	the	DT
cord-001835-0s7ok4uw	2149	15	behavior	behavior	NN
cord-001835-0s7ok4uw	2149	16	of	of	IN
cord-001835-0s7ok4uw	2149	17	Grh1	Grh1	NNP
cord-001835-0s7ok4uw	2149	18	.	.	.
cord-001835-0s7ok4uw	2150	1	Bioinformatics	bioinformatic	NNS
cord-001835-0s7ok4uw	2150	2	and	and	CC
cord-001835-0s7ok4uw	2150	3	circular	circular	JJ
cord-001835-0s7ok4uw	2150	4	dichroism	dichroism	NN
cord-001835-0s7ok4uw	2150	5	(	(	-LRB-
cord-001835-0s7ok4uw	2150	6	CD	CD	NNP
cord-001835-0s7ok4uw	2150	7	)	)	-RRB-
cord-001835-0s7ok4uw	2150	8	analyses	analysis	NNS
cord-001835-0s7ok4uw	2150	9	of	of	IN
cord-001835-0s7ok4uw	2150	10	Grh1	Grh1	NNP
cord-001835-0s7ok4uw	2150	11	indicated	indicate	VBD
cord-001835-0s7ok4uw	2150	12	a	a	DT
cord-001835-0s7ok4uw	2150	13	high	high	JJ
cord-001835-0s7ok4uw	2150	14	percentage	percentage	NN
cord-001835-0s7ok4uw	2150	15	of	of	IN
cord-001835-0s7ok4uw	2150	16	either	either	CC
cord-001835-0s7ok4uw	2150	17	flexible	flexible	JJ
cord-001835-0s7ok4uw	2150	18	regions	region	NNS
cord-001835-0s7ok4uw	2150	19	or	or	CC
cord-001835-0s7ok4uw	2150	20	extended	extended	JJ
cord-001835-0s7ok4uw	2150	21	loops	loop	NNS
cord-001835-0s7ok4uw	2150	22	.	.	.
cord-001835-0s7ok4uw	2151	1	The	the	DT
cord-001835-0s7ok4uw	2151	2	partial	partial	JJ
cord-001835-0s7ok4uw	2151	3	unfolded	unfold	VBN
cord-001835-0s7ok4uw	2151	4	Grh1	Grh1	NNP
cord-001835-0s7ok4uw	2151	5	structure	structure	NN
cord-001835-0s7ok4uw	2151	6	in	in	IN
cord-001835-0s7ok4uw	2151	7	solution	solution	NN
cord-001835-0s7ok4uw	2151	8	folded	fold	VBN
cord-001835-0s7ok4uw	2151	9	into	into	IN
cord-001835-0s7ok4uw	2151	10	more	more	JJR
cord-001835-0s7ok4uw	2151	11	ordered	order	VBN
cord-001835-0s7ok4uw	2151	12	structures	structure	NNS
cord-001835-0s7ok4uw	2151	13	under	under	IN
cord-001835-0s7ok4uw	2151	14	temperature	temperature	NN
cord-001835-0s7ok4uw	2151	15	increasing	increase	VBG
cord-001835-0s7ok4uw	2151	16	,	,	,
cord-001835-0s7ok4uw	2151	17	dehydration	dehydration	NN
cord-001835-0s7ok4uw	2151	18	onto	onto	IN
cord-001835-0s7ok4uw	2151	19	a	a	DT
cord-001835-0s7ok4uw	2151	20	surface	surface	NN
cord-001835-0s7ok4uw	2151	21	and	and	CC
cord-001835-0s7ok4uw	2151	22	nonaqueous	nonaqueous	JJ
cord-001835-0s7ok4uw	2151	23	solvents	solvent	NNS
cord-001835-0s7ok4uw	2151	24	as	as	IN
cord-001835-0s7ok4uw	2151	25	reported	report	VBN
cord-001835-0s7ok4uw	2151	26	also	also	RB
cord-001835-0s7ok4uw	2151	27	by	by	IN
cord-001835-0s7ok4uw	2151	28	CD	CD	NNP
cord-001835-0s7ok4uw	2151	29	.	.	.
cord-001835-0s7ok4uw	2152	1	Hydration	hydration	NN
cord-001835-0s7ok4uw	2152	2	of	of	IN
cord-001835-0s7ok4uw	2152	3	the	the	DT
cord-001835-0s7ok4uw	2152	4	dehydrated	dehydrated	JJ
cord-001835-0s7ok4uw	2152	5	folded	fold	VBN
cord-001835-0s7ok4uw	2152	6	protein	protein	NN
cord-001835-0s7ok4uw	2152	7	is	be	VBZ
cord-001835-0s7ok4uw	2152	8	a	a	DT
cord-001835-0s7ok4uw	2152	9	reversible	reversible	JJ
cord-001835-0s7ok4uw	2152	10	process	process	NN
cord-001835-0s7ok4uw	2152	11	that	that	WDT
cord-001835-0s7ok4uw	2152	12	is	be	VBZ
cord-001835-0s7ok4uw	2152	13	accompanied	accompany	VBN
cord-001835-0s7ok4uw	2152	14	by	by	IN
cord-001835-0s7ok4uw	2152	15	unfolding	unfold	VBG
cord-001835-0s7ok4uw	2152	16	.	.	.
cord-001835-0s7ok4uw	2153	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	2153	2	,	,	,
cord-001835-0s7ok4uw	2153	3	Grh1	Grh1	NNP
cord-001835-0s7ok4uw	2153	4	showed	show	VBD
cord-001835-0s7ok4uw	2153	5	slow	slow	JJ
cord-001835-0s7ok4uw	2153	6	migration	migration	NN
cord-001835-0s7ok4uw	2153	7	in	in	IN
cord-001835-0s7ok4uw	2153	8	SDS	SDS	NNP
cord-001835-0s7ok4uw	2153	9	-	-	HYPH
cord-001835-0s7ok4uw	2153	10	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	2153	11	,	,	,
cord-001835-0s7ok4uw	2153	12	high	high	JJ
cord-001835-0s7ok4uw	2153	13	susceptibility	susceptibility	NN
cord-001835-0s7ok4uw	2153	14	to	to	IN
cord-001835-0s7ok4uw	2153	15	proteases	protease	NNS
cord-001835-0s7ok4uw	2153	16	and	and	CC
cord-001835-0s7ok4uw	2153	17	low	low	JJ
cord-001835-0s7ok4uw	2153	18	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	2153	19	of	of	IN
cord-001835-0s7ok4uw	2153	20	the	the	DT
cord-001835-0s7ok4uw	2153	21	chemical	chemical	NN
cord-001835-0s7ok4uw	2153	22	-	-	HYPH
cord-001835-0s7ok4uw	2153	23	induced	induce	VBN
cord-001835-0s7ok4uw	2153	24	unfolding	unfold	VBG
cord-001835-0s7ok4uw	2153	25	process	process	NN
cord-001835-0s7ok4uw	2153	26	.	.	.
cord-001835-0s7ok4uw	2154	1	Fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2154	2	of	of	IN
cord-001835-0s7ok4uw	2154	3	Trp	trp	NN
cord-001835-0s7ok4uw	2154	4	residues	residue	NNS
cord-001835-0s7ok4uw	2154	5	along	along	IN
cord-001835-0s7ok4uw	2154	6	with	with	IN
cord-001835-0s7ok4uw	2154	7	CD	CD	NNP
cord-001835-0s7ok4uw	2154	8	data	datum	NNS
cord-001835-0s7ok4uw	2154	9	showed	show	VBD
cord-001835-0s7ok4uw	2154	10	Grh1	Grh1	NNP
cord-001835-0s7ok4uw	2154	11	preserves	preserve	VBZ
cord-001835-0s7ok4uw	2154	12	a	a	DT
cord-001835-0s7ok4uw	2154	13	considerable	considerable	JJ
cord-001835-0s7ok4uw	2154	14	amount	amount	NN
cord-001835-0s7ok4uw	2154	15	of	of	IN
cord-001835-0s7ok4uw	2154	16	residual	residual	JJ
cord-001835-0s7ok4uw	2154	17	secondary	secondary	JJ
cord-001835-0s7ok4uw	2154	18	structure	structure	NN
cord-001835-0s7ok4uw	2154	19	,	,	,
cord-001835-0s7ok4uw	2154	20	and	and	CC
cord-001835-0s7ok4uw	2154	21	the	the	DT
cord-001835-0s7ok4uw	2154	22	unfolding	unfold	VBG
cord-001835-0s7ok4uw	2154	23	transition	transition	NN
cord-001835-0s7ok4uw	2154	24	monitored	monitor	VBN
cord-001835-0s7ok4uw	2154	25	by	by	IN
cord-001835-0s7ok4uw	2154	26	Trp	Trp	NNP
cord-001835-0s7ok4uw	2154	27	presented	present	VBD
cord-001835-0s7ok4uw	2154	28	higher	high	JJR
cord-001835-0s7ok4uw	2154	29	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	2154	30	.	.	.
cord-001835-0s7ok4uw	2155	1	Another	another	DT
cord-001835-0s7ok4uw	2155	2	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	2155	3	transition	transition	NN
cord-001835-0s7ok4uw	2155	4	was	be	VBD
cord-001835-0s7ok4uw	2155	5	also	also	RB
cord-001835-0s7ok4uw	2155	6	reported	report	VBN
cord-001835-0s7ok4uw	2155	7	by	by	IN
cord-001835-0s7ok4uw	2155	8	the	the	DT
cord-001835-0s7ok4uw	2155	9	extrinsic	extrinsic	JJ
cord-001835-0s7ok4uw	2155	10	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	2155	11	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2155	12	probe	probe	NN
cord-001835-0s7ok4uw	2155	13	ANS	an	NNS
cord-001835-0s7ok4uw	2155	14	upon	upon	IN
cord-001835-0s7ok4uw	2155	15	chemical	chemical	JJ
cord-001835-0s7ok4uw	2155	16	denaturation	denaturation	NN
cord-001835-0s7ok4uw	2155	17	.	.	.
cord-001835-0s7ok4uw	2156	1	These	these	DT
cord-001835-0s7ok4uw	2156	2	set	set	NN
cord-001835-0s7ok4uw	2156	3	of	of	IN
cord-001835-0s7ok4uw	2156	4	experiments	experiment	NNS
cord-001835-0s7ok4uw	2156	5	indicate	indicate	VBP
cord-001835-0s7ok4uw	2156	6	that	that	IN
cord-001835-0s7ok4uw	2156	7	Grh1	Grh1	NNP
cord-001835-0s7ok4uw	2156	8	behaves	behave	VBZ
cord-001835-0s7ok4uw	2156	9	as	as	IN
cord-001835-0s7ok4uw	2156	10	a	a	DT
cord-001835-0s7ok4uw	2156	11	protein	protein	NN
cord-001835-0s7ok4uw	2156	12	containing	contain	VBG
cord-001835-0s7ok4uw	2156	13	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2156	14	disordered	disordered	JJ
cord-001835-0s7ok4uw	2156	15	regions	region	NNS
cord-001835-0s7ok4uw	2156	16	(	(	-LRB-
cord-001835-0s7ok4uw	2156	17	IDRs	IDRs	NNP
cord-001835-0s7ok4uw	2156	18	)	)	-RRB-
cord-001835-0s7ok4uw	2156	19	,	,	,
cord-001835-0s7ok4uw	2156	20	characterized	characterize	VBN
cord-001835-0s7ok4uw	2156	21	by	by	IN
cord-001835-0s7ok4uw	2156	22	unstructured	unstructured	JJ
cord-001835-0s7ok4uw	2156	23	regions	region	NNS
cord-001835-0s7ok4uw	2156	24	of	of	IN
cord-001835-0s7ok4uw	2156	25	high	high	JJ
cord-001835-0s7ok4uw	2156	26	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	2156	27	mobility	mobility	NN
cord-001835-0s7ok4uw	2156	28	experiencing	experience	VBG
cord-001835-0s7ok4uw	2156	29	many	many	JJ
cord-001835-0s7ok4uw	2156	30	conformations	conformation	NNS
cord-001835-0s7ok4uw	2156	31	.	.	.
cord-001835-0s7ok4uw	2157	1	These	these	DT
cord-001835-0s7ok4uw	2157	2	findings	finding	NNS
cord-001835-0s7ok4uw	2157	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	2157	4	that	that	IN
cord-001835-0s7ok4uw	2157	5	an	an	DT
cord-001835-0s7ok4uw	2157	6	IDP	IDP	NNP
cord-001835-0s7ok4uw	2157	7	-	-	HYPH
cord-001835-0s7ok4uw	2157	8	like	like	JJ
cord-001835-0s7ok4uw	2157	9	behavior	behavior	NN
cord-001835-0s7ok4uw	2157	10	may	may	MD
cord-001835-0s7ok4uw	2157	11	be	be	VB
cord-001835-0s7ok4uw	2157	12	the	the	DT
cord-001835-0s7ok4uw	2157	13	solution	solution	NN
cord-001835-0s7ok4uw	2157	14	found	find	VBN
cord-001835-0s7ok4uw	2157	15	by	by	IN
cord-001835-0s7ok4uw	2157	16	Nature	Nature	NNP
cord-001835-0s7ok4uw	2157	17	to	to	TO
cord-001835-0s7ok4uw	2157	18	account	account	VB
cord-001835-0s7ok4uw	2157	19	for	for	IN
cord-001835-0s7ok4uw	2157	20	Grh1	grh1	JJ
cord-001835-0s7ok4uw	2157	21	functional	functional	JJ
cord-001835-0s7ok4uw	2157	22	need	need	NN
cord-001835-0s7ok4uw	2157	23	for	for	IN
cord-001835-0s7ok4uw	2157	24	interactions	interaction	NNS
cord-001835-0s7ok4uw	2157	25	with	with	IN
cord-001835-0s7ok4uw	2157	26	several	several	JJ
cord-001835-0s7ok4uw	2157	27	different	different	JJ
cord-001835-0s7ok4uw	2157	28	partners	partner	NNS
cord-001835-0s7ok4uw	2157	29	in	in	IN
cord-001835-0s7ok4uw	2157	30	the	the	DT
cord-001835-0s7ok4uw	2157	31	cell	cell	NN
cord-001835-0s7ok4uw	2157	32	.	.	.
cord-001835-0s7ok4uw	2158	1	Conformational	Conformational	NNP
cord-001835-0s7ok4uw	2158	2	changes	change	VBZ
cord-001835-0s7ok4uw	2158	3	governing	govern	VBG
cord-001835-0s7ok4uw	2158	4	dengue	dengue	NN
cord-001835-0s7ok4uw	2158	5	virus	virus	NN
cord-001835-0s7ok4uw	2158	6	capsid	capsid	NN
cord-001835-0s7ok4uw	2158	7	protein	protein	NN
cord-001835-0s7ok4uw	2158	8	function	function	NN
cord-001835-0s7ok4uw	2158	9	and	and	CC
cord-001835-0s7ok4uw	2158	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2158	11	inhibition	inhibition	NN
cord-001835-0s7ok4uw	2158	12	by	by	IN
cord-001835-0s7ok4uw	2158	13	pep14	pep14	CD
cord-001835-0s7ok4uw	2158	14	23	23	CD
cord-001835-0s7ok4uw	2158	15	Andr	Andr	NNP
cord-001835-0s7ok4uw	2158	16	e	e	NN
cord-001835-0s7ok4uw	2158	17	F.	F.	NNP
cord-001835-0s7ok4uw	2158	18	ABSTRACT	ABSTRACT	NNP
cord-001835-0s7ok4uw	2158	19	Dengue	Dengue	NNP
cord-001835-0s7ok4uw	2158	20	virus	virus	NN
cord-001835-0s7ok4uw	2158	21	(	(	-LRB-
cord-001835-0s7ok4uw	2158	22	DENV	DENV	NNP
cord-001835-0s7ok4uw	2158	23	)	)	-RRB-
cord-001835-0s7ok4uw	2158	24	infection	infection	NN
cord-001835-0s7ok4uw	2158	25	affects	affect	VBZ
cord-001835-0s7ok4uw	2158	26	millions	million	NNS
cord-001835-0s7ok4uw	2158	27	of	of	IN
cord-001835-0s7ok4uw	2158	28	people	people	NNS
cord-001835-0s7ok4uw	2158	29	and	and	CC
cord-001835-0s7ok4uw	2158	30	is	be	VBZ
cord-001835-0s7ok4uw	2158	31	becoming	become	VBG
cord-001835-0s7ok4uw	2158	32	a	a	DT
cord-001835-0s7ok4uw	2158	33	major	major	JJ
cord-001835-0s7ok4uw	2158	34	global	global	JJ
cord-001835-0s7ok4uw	2158	35	disease	disease	NN
cord-001835-0s7ok4uw	2158	36	for	for	IN
cord-001835-0s7ok4uw	2158	37	which	which	WDT
cord-001835-0s7ok4uw	2158	38	there	there	EX
cord-001835-0s7ok4uw	2158	39	is	be	VBZ
cord-001835-0s7ok4uw	2158	40	no	no	DT
cord-001835-0s7ok4uw	2158	41	specific	specific	JJ
cord-001835-0s7ok4uw	2158	42	treatment	treatment	NN
cord-001835-0s7ok4uw	2158	43	available	available	JJ
cord-001835-0s7ok4uw	2158	44	.	.	.
cord-001835-0s7ok4uw	2159	1	The	the	DT
cord-001835-0s7ok4uw	2159	2	interaction	interaction	NN
cord-001835-0s7ok4uw	2159	3	of	of	IN
cord-001835-0s7ok4uw	2159	4	DENV	DENV	NNP
cord-001835-0s7ok4uw	2159	5	capsid	capsid	NN
cord-001835-0s7ok4uw	2159	6	(	(	-LRB-
cord-001835-0s7ok4uw	2159	7	C	C	NNP
cord-001835-0s7ok4uw	2159	8	)	)	-RRB-
cord-001835-0s7ok4uw	2159	9	protein	protein	NN
cord-001835-0s7ok4uw	2159	10	with	with	IN
cord-001835-0s7ok4uw	2159	11	host	host	NN
cord-001835-0s7ok4uw	2159	12	lipid	lipid	NN
cord-001835-0s7ok4uw	2159	13	droplets	droplet	NNS
cord-001835-0s7ok4uw	2159	14	(	(	-LRB-
cord-001835-0s7ok4uw	2159	15	LDs	LDs	NNP
cord-001835-0s7ok4uw	2159	16	)	)	-RRB-
cord-001835-0s7ok4uw	2159	17	is	be	VBZ
cord-001835-0s7ok4uw	2159	18	essential	essential	JJ
cord-001835-0s7ok4uw	2159	19	for	for	IN
cord-001835-0s7ok4uw	2159	20	viral	viral	JJ
cord-001835-0s7ok4uw	2159	21	replication	replication	NN
cord-001835-0s7ok4uw	2159	22	.	.	.
cord-001835-0s7ok4uw	2160	1	pep14	pep14	CD
cord-001835-0s7ok4uw	2160	2	-	-	SYM
cord-001835-0s7ok4uw	2160	3	23	23	CD
cord-001835-0s7ok4uw	2160	4	,	,	,
cord-001835-0s7ok4uw	2160	5	a	a	DT
cord-001835-0s7ok4uw	2160	6	peptide	peptide	NN
cord-001835-0s7ok4uw	2160	7	designed	design	VBN
cord-001835-0s7ok4uw	2160	8	based	base	VBN
cord-001835-0s7ok4uw	2160	9	on	on	IN
cord-001835-0s7ok4uw	2160	10	a	a	DT
cord-001835-0s7ok4uw	2160	11	DENV	DENV	NNP
cord-001835-0s7ok4uw	2160	12	C	C	NNP
cord-001835-0s7ok4uw	2160	13	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2160	14	disordered	disorder	VBD
cord-001835-0s7ok4uw	2160	15	conserved	conserved	JJ
cord-001835-0s7ok4uw	2160	16	region	region	NN
cord-001835-0s7ok4uw	2160	17	,	,	,
cord-001835-0s7ok4uw	2160	18	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	2160	19	this	this	DT
cord-001835-0s7ok4uw	2160	20	crucial	crucial	JJ
cord-001835-0s7ok4uw	2160	21	interaction	interaction	NN
cord-001835-0s7ok4uw	2160	22	.	.	.
cord-001835-0s7ok4uw	2161	1	Combining	combine	VBG
cord-001835-0s7ok4uw	2161	2	bioinformatics	bioinformatic	NNS
cord-001835-0s7ok4uw	2161	3	and	and	CC
cord-001835-0s7ok4uw	2161	4	biophysics	biophysic	NNS
cord-001835-0s7ok4uw	2161	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2161	6	determined	determine	VBD
cord-001835-0s7ok4uw	2161	7	pep14	pep14	CD
cord-001835-0s7ok4uw	2161	8	-	-	HYPH
cord-001835-0s7ok4uw	2161	9	23	23	CD
cord-001835-0s7ok4uw	2161	10	structure	structure	NN
cord-001835-0s7ok4uw	2161	11	and	and	CC
cord-001835-0s7ok4uw	2161	12	ability	ability	NN
cord-001835-0s7ok4uw	2161	13	to	to	TO
cord-001835-0s7ok4uw	2161	14	bind	bind	VB
cord-001835-0s7ok4uw	2161	15	different	different	JJ
cord-001835-0s7ok4uw	2161	16	phospholipids	phospholipid	NNS
cord-001835-0s7ok4uw	2161	17	,	,	,
cord-001835-0s7ok4uw	2161	18	in	in	IN
cord-001835-0s7ok4uw	2161	19	the	the	DT
cord-001835-0s7ok4uw	2161	20	context	context	NN
cord-001835-0s7ok4uw	2161	21	of	of	IN
cord-001835-0s7ok4uw	2161	22	DENV	DENV	NNP
cord-001835-0s7ok4uw	2161	23	C	C	NNP
cord-001835-0s7ok4uw	2161	24	function	function	NN
cord-001835-0s7ok4uw	2161	25	.	.	.
cord-001835-0s7ok4uw	2162	1	pep14	pep14	LS
cord-001835-0s7ok4uw	2162	2	-	-	SYM
cord-001835-0s7ok4uw	2162	3	23	23	CD
cord-001835-0s7ok4uw	2162	4	becomes	become	VBZ
cord-001835-0s7ok4uw	2162	5	a	a	DT
cord-001835-0s7ok4uw	2162	6	-	-	HYPH
cord-001835-0s7ok4uw	2162	7	helical	helical	JJ
cord-001835-0s7ok4uw	2162	8	upon	upon	IN
cord-001835-0s7ok4uw	2162	9	binding	bind	VBG
cord-001835-0s7ok4uw	2162	10	to	to	IN
cord-001835-0s7ok4uw	2162	11	anionic	anionic	JJ
cord-001835-0s7ok4uw	2162	12	phospholipids	phospholipid	NNS
cord-001835-0s7ok4uw	2162	13	.	.	.
cord-001835-0s7ok4uw	2163	1	Structure	structure	NN
cord-001835-0s7ok4uw	2163	2	prediction	prediction	NN
cord-001835-0s7ok4uw	2163	3	of	of	IN
cord-001835-0s7ok4uw	2163	4	DENV	DENV	NNP
cord-001835-0s7ok4uw	2163	5	C	C	NNP
cord-001835-0s7ok4uw	2163	6	N	N	NNP
cord-001835-0s7ok4uw	2163	7	-	-	HYPH
cord-001835-0s7ok4uw	2163	8	terminal	terminal	NN
cord-001835-0s7ok4uw	2163	9	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2163	10	disordered	disordered	JJ
cord-001835-0s7ok4uw	2163	11	region	region	NN
cord-001835-0s7ok4uw	2163	12	reveals	reveal	VBZ
cord-001835-0s7ok4uw	2163	13	orientations	orientation	NNS
cord-001835-0s7ok4uw	2163	14	that	that	WDT
cord-001835-0s7ok4uw	2163	15	alternatively	alternatively	RB
cord-001835-0s7ok4uw	2163	16	shield	shield	VBP
cord-001835-0s7ok4uw	2163	17	or	or	CC
cord-001835-0s7ok4uw	2163	18	expose	expose	VB
cord-001835-0s7ok4uw	2163	19	DENV	DENV	NNP
cord-001835-0s7ok4uw	2163	20	C	C	NNP
cord-001835-0s7ok4uw	2163	21	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	2163	22	pocket	pocket	NN
cord-001835-0s7ok4uw	2163	23	,	,	,
cord-001835-0s7ok4uw	2163	24	supporting	support	VBG
cord-001835-0s7ok4uw	2163	25	a	a	DT
cord-001835-0s7ok4uw	2163	26	novel	novel	JJ
cord-001835-0s7ok4uw	2163	27	autoinhibitory	autoinhibitory	JJ
cord-001835-0s7ok4uw	2163	28	role	role	NN
cord-001835-0s7ok4uw	2163	29	for	for	IN
cord-001835-0s7ok4uw	2163	30	this	this	DT
cord-001835-0s7ok4uw	2163	31	region	region	NN
cord-001835-0s7ok4uw	2163	32	.	.	.
cord-001835-0s7ok4uw	2164	1	These	these	DT
cord-001835-0s7ok4uw	2164	2	findings	finding	NNS
cord-001835-0s7ok4uw	2164	3	pave	pave	VBP
cord-001835-0s7ok4uw	2164	4	the	the	DT
cord-001835-0s7ok4uw	2164	5	way	way	NN
cord-001835-0s7ok4uw	2164	6	for	for	IN
cord-001835-0s7ok4uw	2164	7	similar	similar	JJ
cord-001835-0s7ok4uw	2164	8	studies	study	NNS
cord-001835-0s7ok4uw	2164	9	to	to	TO
cord-001835-0s7ok4uw	2164	10	understand	understand	VB
cord-001835-0s7ok4uw	2164	11	disordered	disordered	JJ
cord-001835-0s7ok4uw	2164	12	proteins	protein	NNS
cord-001835-0s7ok4uw	2164	13	and	and	CC
cord-001835-0s7ok4uw	2164	14	improved	improve	VBD
cord-001835-0s7ok4uw	2164	15	peptidomimetics	peptidomimetics	NNP
cord-001835-0s7ok4uw	2164	16	drug	drug	NNP
cord-001835-0s7ok4uw	2164	17	development	development	NN
cord-001835-0s7ok4uw	2164	18	strategies	strategy	NNS
cord-001835-0s7ok4uw	2164	19	against	against	IN
cord-001835-0s7ok4uw	2164	20	flaviviruses	flavivirus	NNS
cord-001835-0s7ok4uw	2164	21	.	.	.
cord-001835-0s7ok4uw	2165	1	TOPICS	topic	NNS
cord-001835-0s7ok4uw	2166	1	Intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2166	2	Disordered	disordered	JJ
cord-001835-0s7ok4uw	2166	3	Proteins	Proteins	NNP
cord-001835-0s7ok4uw	2166	4	Protein	Protein	NNP
cord-001835-0s7ok4uw	2166	5	-	-	HYPH
cord-001835-0s7ok4uw	2166	6	Lipid	Lipid	NNP
cord-001835-0s7ok4uw	2166	7	Interactions	Interactions	NNPS
cord-001835-0s7ok4uw	2167	1	PF-015	pf-015	JJ
cord-001835-0s7ok4uw	2167	2	Developing	develop	VBG
cord-001835-0s7ok4uw	2167	3	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	2167	4	insight	insight	NN
cord-001835-0s7ok4uw	2167	5	into	into	IN
cord-001835-0s7ok4uw	2167	6	modulators	modulator	NNS
cord-001835-0s7ok4uw	2167	7	of	of	IN
cord-001835-0s7ok4uw	2167	8	tau	tau	NN
cord-001835-0s7ok4uw	2167	9	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2167	10	Eri	Eri	NNP
cord-001835-0s7ok4uw	2167	11	Nakatani	Nakatani	NNP
cord-001835-0s7ok4uw	2167	12	-	-	HYPH
cord-001835-0s7ok4uw	2167	13	Webster	Webster	NNP
cord-001835-0s7ok4uw	2167	14	1	1	CD
cord-001835-0s7ok4uw	2167	15	,	,	,
cord-001835-0s7ok4uw	2167	16	Hannah	Hannah	NNP
cord-001835-0s7ok4uw	2167	17	Baughman	Baughman	NNP
cord-001835-0s7ok4uw	2167	18	1	1	CD
cord-001835-0s7ok4uw	2167	19	,	,	,
cord-001835-0s7ok4uw	2167	20	Shaylin	Shaylin	NNP
cord-001835-0s7ok4uw	2167	21	Higgins	Higgins	NNP
cord-001835-0s7ok4uw	2167	22	1	1	CD
cord-001835-0s7ok4uw	2167	23	,	,	,
cord-001835-0s7ok4uw	2167	24	Abhinav	Abhinav	NNP
cord-001835-0s7ok4uw	2167	25	Nath	Nath	NNP
cord-001835-0s7ok4uw	2167	26	1	1	CD
cord-001835-0s7ok4uw	2167	27	1	1	CD
cord-001835-0s7ok4uw	2168	1	The	the	DT
cord-001835-0s7ok4uw	2168	2	pathological	pathological	JJ
cord-001835-0s7ok4uw	2168	3	self	self	NN
cord-001835-0s7ok4uw	2168	4	-	-	HYPH
cord-001835-0s7ok4uw	2168	5	association	association	NN
cord-001835-0s7ok4uw	2168	6	of	of	IN
cord-001835-0s7ok4uw	2168	7	microtubule	microtubule	NNP
cord-001835-0s7ok4uw	2168	8	-	-	HYPH
cord-001835-0s7ok4uw	2168	9	associated	associate	VBN
cord-001835-0s7ok4uw	2168	10	protein	protein	NN
cord-001835-0s7ok4uw	2168	11	tau	tau	NNP
cord-001835-0s7ok4uw	2168	12	is	be	VBZ
cord-001835-0s7ok4uw	2168	13	implicated	implicate	VBN
cord-001835-0s7ok4uw	2168	14	in	in	IN
cord-001835-0s7ok4uw	2168	15	a	a	DT
cord-001835-0s7ok4uw	2168	16	range	range	NN
cord-001835-0s7ok4uw	2168	17	of	of	IN
cord-001835-0s7ok4uw	2168	18	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	2168	19	disorders	disorder	NNS
cord-001835-0s7ok4uw	2168	20	collectively	collectively	RB
cord-001835-0s7ok4uw	2168	21	called	call	VBN
cord-001835-0s7ok4uw	2168	22	tauopathies	tauopathie	NNS
cord-001835-0s7ok4uw	2168	23	,	,	,
cord-001835-0s7ok4uw	2168	24	perhaps	perhaps	RB
cord-001835-0s7ok4uw	2168	25	the	the	DT
cord-001835-0s7ok4uw	2168	26	most	most	RBS
cord-001835-0s7ok4uw	2168	27	prominent	prominent	JJ
cord-001835-0s7ok4uw	2168	28	of	of	IN
cord-001835-0s7ok4uw	2168	29	which	which	WDT
cord-001835-0s7ok4uw	2168	30	are	be	VBP
cord-001835-0s7ok4uw	2168	31	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	2168	32	's	's	POS
cord-001835-0s7ok4uw	2168	33	disease	disease	NN
cord-001835-0s7ok4uw	2168	34	(	(	-LRB-
cord-001835-0s7ok4uw	2168	35	AD	ad	NN
cord-001835-0s7ok4uw	2168	36	)	)	-RRB-
cord-001835-0s7ok4uw	2168	37	and	and	CC
cord-001835-0s7ok4uw	2168	38	chronic	chronic	JJ
cord-001835-0s7ok4uw	2168	39	traumatic	traumatic	JJ
cord-001835-0s7ok4uw	2168	40	encephalopathy	encephalopathy	NN
cord-001835-0s7ok4uw	2168	41	(	(	-LRB-
cord-001835-0s7ok4uw	2168	42	CTE	CTE	NNP
cord-001835-0s7ok4uw	2168	43	)	)	-RRB-
cord-001835-0s7ok4uw	2168	44	.	.	.
cord-001835-0s7ok4uw	2169	1	Tau	Tau	NNP
cord-001835-0s7ok4uw	2169	2	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2169	3	in	in	IN
cord-001835-0s7ok4uw	2169	4	vitro	vitro	FW
cord-001835-0s7ok4uw	2169	5	shares	share	VBZ
cord-001835-0s7ok4uw	2169	6	many	many	JJ
cord-001835-0s7ok4uw	2169	7	features	feature	NNS
cord-001835-0s7ok4uw	2169	8	in	in	IN
cord-001835-0s7ok4uw	2169	9	common	common	JJ
cord-001835-0s7ok4uw	2169	10	with	with	IN
cord-001835-0s7ok4uw	2169	11	fibril	fibril	NNP
cord-001835-0s7ok4uw	2169	12	formation	formation	NN
cord-001835-0s7ok4uw	2169	13	by	by	IN
cord-001835-0s7ok4uw	2169	14	other	other	JJ
cord-001835-0s7ok4uw	2169	15	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2169	16	-	-	HYPH
cord-001835-0s7ok4uw	2169	17	forming	form	VBG
cord-001835-0s7ok4uw	2169	18	proteins	protein	NNS
cord-001835-0s7ok4uw	2169	19	:	:	:
cord-001835-0s7ok4uw	2170	1	a	a	DT
cord-001835-0s7ok4uw	2170	2	nucleationdependent	nucleationdependent	JJ
cord-001835-0s7ok4uw	2170	3	polymerization	polymerization	NN
cord-001835-0s7ok4uw	2170	4	reaction	reaction	NN
cord-001835-0s7ok4uw	2170	5	progressing	progress	VBG
cord-001835-0s7ok4uw	2170	6	via	via	IN
cord-001835-0s7ok4uw	2170	7	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2170	8	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	2170	9	into	into	IN
cord-001835-0s7ok4uw	2170	10	b	b	NN
cord-001835-0s7ok4uw	2170	11	-	-	HYPH
cord-001835-0s7ok4uw	2170	12	sheet	sheet	NN
cord-001835-0s7ok4uw	2170	13	-	-	HYPH
cord-001835-0s7ok4uw	2170	14	rich	rich	JJ
cord-001835-0s7ok4uw	2170	15	fibrillar	fibrillar	NNP
cord-001835-0s7ok4uw	2170	16	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	2170	17	,	,	,
cord-001835-0s7ok4uw	2170	18	characterized	characterize	VBN
cord-001835-0s7ok4uw	2170	19	by	by	IN
cord-001835-0s7ok4uw	2170	20	a	a	DT
cord-001835-0s7ok4uw	2170	21	distinctive	distinctive	JJ
cord-001835-0s7ok4uw	2170	22	sigmoidal	sigmoidal	JJ
cord-001835-0s7ok4uw	2170	23	kinetic	kinetic	NN
cord-001835-0s7ok4uw	2170	24	.	.	.
cord-001835-0s7ok4uw	2171	1	Over	over	IN
cord-001835-0s7ok4uw	2171	2	the	the	DT
cord-001835-0s7ok4uw	2171	3	years	year	NNS
cord-001835-0s7ok4uw	2171	4	,	,	,
cord-001835-0s7ok4uw	2171	5	many	many	JJ
cord-001835-0s7ok4uw	2171	6	investigators	investigator	NNS
cord-001835-0s7ok4uw	2171	7	have	have	VBP
cord-001835-0s7ok4uw	2171	8	advanced	advance	VBN
cord-001835-0s7ok4uw	2171	9	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2171	10	understanding	understanding	NN
cord-001835-0s7ok4uw	2171	11	of	of	IN
cord-001835-0s7ok4uw	2171	12	how	how	WRB
cord-001835-0s7ok4uw	2171	13	these	these	DT
cord-001835-0s7ok4uw	2171	14	time	time	NN
cord-001835-0s7ok4uw	2171	15	-	-	HYPH
cord-001835-0s7ok4uw	2171	16	courses	course	NNS
cord-001835-0s7ok4uw	2171	17	might	may	MD
cord-001835-0s7ok4uw	2171	18	best	best	RB
cord-001835-0s7ok4uw	2171	19	be	be	VB
cord-001835-0s7ok4uw	2171	20	characterized	characterize	VBN
cord-001835-0s7ok4uw	2171	21	and	and	CC
cord-001835-0s7ok4uw	2171	22	interpreted	interpret	VBN
cord-001835-0s7ok4uw	2171	23	.	.	.
cord-001835-0s7ok4uw	2172	1	In	in	IN
cord-001835-0s7ok4uw	2172	2	particular	particular	JJ
cord-001835-0s7ok4uw	2172	3	,	,	,
cord-001835-0s7ok4uw	2172	4	elegant	elegant	JJ
cord-001835-0s7ok4uw	2172	5	analytical	analytical	JJ
cord-001835-0s7ok4uw	2172	6	and	and	CC
cord-001835-0s7ok4uw	2172	7	numerical	numerical	JJ
cord-001835-0s7ok4uw	2172	8	approaches	approach	NNS
cord-001835-0s7ok4uw	2172	9	have	have	VBP
cord-001835-0s7ok4uw	2172	10	been	be	VBN
cord-001835-0s7ok4uw	2172	11	developed	develop	VBN
cord-001835-0s7ok4uw	2172	12	that	that	WDT
cord-001835-0s7ok4uw	2172	13	supersede	supersede	VBP
cord-001835-0s7ok4uw	2172	14	the	the	DT
cord-001835-0s7ok4uw	2172	15	empirical	empirical	JJ
cord-001835-0s7ok4uw	2172	16	sigmoidal	sigmoidal	JJ
cord-001835-0s7ok4uw	2172	17	equations	equation	NNS
cord-001835-0s7ok4uw	2172	18	typically	typically	RB
cord-001835-0s7ok4uw	2172	19	used	use	VBN
cord-001835-0s7ok4uw	2172	20	to	to	TO
cord-001835-0s7ok4uw	2172	21	fit	fit	VB
cord-001835-0s7ok4uw	2172	22	fibril	fibril	NNP
cord-001835-0s7ok4uw	2172	23	formation	formation	NN
cord-001835-0s7ok4uw	2172	24	traces	trace	NNS
cord-001835-0s7ok4uw	2172	25	.	.	.
cord-001835-0s7ok4uw	2173	1	These	these	DT
cord-001835-0s7ok4uw	2173	2	modern	modern	JJ
cord-001835-0s7ok4uw	2173	3	approaches	approach	NNS
cord-001835-0s7ok4uw	2173	4	have	have	VBP
cord-001835-0s7ok4uw	2173	5	enabled	enable	VBN
cord-001835-0s7ok4uw	2173	6	more	more	RBR
cord-001835-0s7ok4uw	2173	7	rigorous	rigorous	JJ
cord-001835-0s7ok4uw	2173	8	insight	insight	NN
cord-001835-0s7ok4uw	2173	9	into	into	IN
cord-001835-0s7ok4uw	2173	10	the	the	DT
cord-001835-0s7ok4uw	2173	11	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2173	12	of	of	IN
cord-001835-0s7ok4uw	2173	13	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2173	14	formation	formation	NN
cord-001835-0s7ok4uw	2173	15	,	,	,
cord-001835-0s7ok4uw	2173	16	and	and	CC
cord-001835-0s7ok4uw	2173	17	into	into	IN
cord-001835-0s7ok4uw	2173	18	how	how	WRB
cord-001835-0s7ok4uw	2173	19	small	small	JJ
cord-001835-0s7ok4uw	2173	20	molecules	molecule	NNS
cord-001835-0s7ok4uw	2173	21	,	,	,
cord-001835-0s7ok4uw	2173	22	protein	protein	NN
cord-001835-0s7ok4uw	2173	23	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	2173	24	,	,	,
cord-001835-0s7ok4uw	2173	25	and	and	CC
cord-001835-0s7ok4uw	2173	26	other	other	JJ
cord-001835-0s7ok4uw	2173	27	binding	bind	VBG
cord-001835-0s7ok4uw	2173	28	partners	partner	NNS
cord-001835-0s7ok4uw	2173	29	can	can	MD
cord-001835-0s7ok4uw	2173	30	modulate	modulate	VB
cord-001835-0s7ok4uw	2173	31	the	the	DT
cord-001835-0s7ok4uw	2173	32	process	process	NN
cord-001835-0s7ok4uw	2173	33	.	.	.
cord-001835-0s7ok4uw	2174	1	An	an	DT
cord-001835-0s7ok4uw	2174	2	understanding	understanding	NN
cord-001835-0s7ok4uw	2174	3	of	of	IN
cord-001835-0s7ok4uw	2174	4	a	a	DT
cord-001835-0s7ok4uw	2174	5	modulator	modulator	NN
cord-001835-0s7ok4uw	2174	6	's	's	POS
cord-001835-0s7ok4uw	2174	7	effects	effect	NNS
cord-001835-0s7ok4uw	2174	8	on	on	IN
cord-001835-0s7ok4uw	2174	9	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2174	10	formation	formation	NN
cord-001835-0s7ok4uw	2174	11	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2174	12	is	be	VBZ
cord-001835-0s7ok4uw	2174	13	necessary	necessary	JJ
cord-001835-0s7ok4uw	2174	14	in	in	IN
cord-001835-0s7ok4uw	2174	15	order	order	NN
cord-001835-0s7ok4uw	2174	16	for	for	IN
cord-001835-0s7ok4uw	2174	17	us	-PRON-	PRP
cord-001835-0s7ok4uw	2174	18	to	to	TO
cord-001835-0s7ok4uw	2174	19	predict	predict	VB
cord-001835-0s7ok4uw	2174	20	and	and	CC
cord-001835-0s7ok4uw	2174	21	engineer	engineer	VB
cord-001835-0s7ok4uw	2174	22	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2174	23	effects	effect	NNS
cord-001835-0s7ok4uw	2174	24	on	on	IN
cord-001835-0s7ok4uw	2174	25	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2174	26	pathology	pathology	NN
cord-001835-0s7ok4uw	2174	27	in	in	IN
cord-001835-0s7ok4uw	2174	28	a	a	DT
cord-001835-0s7ok4uw	2174	29	biological	biological	JJ
cord-001835-0s7ok4uw	2174	30	context	context	NN
cord-001835-0s7ok4uw	2174	31	.	.	.
cord-001835-0s7ok4uw	2175	1	A	a	DT
cord-001835-0s7ok4uw	2175	2	given	give	VBN
cord-001835-0s7ok4uw	2175	3	modulator	modulator	NN
cord-001835-0s7ok4uw	2175	4	may	may	MD
cord-001835-0s7ok4uw	2175	5	affect	affect	VB
cord-001835-0s7ok4uw	2175	6	rates	rate	NNS
cord-001835-0s7ok4uw	2175	7	of	of	IN
cord-001835-0s7ok4uw	2175	8	primary	primary	JJ
cord-001835-0s7ok4uw	2175	9	or	or	CC
cord-001835-0s7ok4uw	2175	10	secondary	secondary	JJ
cord-001835-0s7ok4uw	2175	11	nucleation	nucleation	NN
cord-001835-0s7ok4uw	2175	12	,	,	,
cord-001835-0s7ok4uw	2175	13	elongation	elongation	NN
cord-001835-0s7ok4uw	2175	14	,	,	,
cord-001835-0s7ok4uw	2175	15	or	or	CC
cord-001835-0s7ok4uw	2175	16	fibril	fibril	NN
cord-001835-0s7ok4uw	2175	17	fragmentation	fragmentation	NN
cord-001835-0s7ok4uw	2175	18	to	to	IN
cord-001835-0s7ok4uw	2175	19	different	different	JJ
cord-001835-0s7ok4uw	2175	20	extents	extent	NNS
cord-001835-0s7ok4uw	2175	21	.	.	.
cord-001835-0s7ok4uw	2176	1	Each	each	DT
cord-001835-0s7ok4uw	2176	2	of	of	IN
cord-001835-0s7ok4uw	2176	3	these	these	DT
cord-001835-0s7ok4uw	2176	4	perturbations	perturbation	NNS
cord-001835-0s7ok4uw	2176	5	,	,	,
cord-001835-0s7ok4uw	2176	6	individually	individually	RB
cord-001835-0s7ok4uw	2176	7	or	or	CC
cord-001835-0s7ok4uw	2176	8	in	in	IN
cord-001835-0s7ok4uw	2176	9	combination	combination	NN
cord-001835-0s7ok4uw	2176	10	,	,	,
cord-001835-0s7ok4uw	2176	11	can	can	MD
cord-001835-0s7ok4uw	2176	12	alter	alter	VB
cord-001835-0s7ok4uw	2176	13	the	the	DT
cord-001835-0s7ok4uw	2176	14	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2176	15	of	of	IN
cord-001835-0s7ok4uw	2176	16	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2176	17	,	,	,
cord-001835-0s7ok4uw	2176	18	the	the	DT
cord-001835-0s7ok4uw	2176	19	final	final	JJ
cord-001835-0s7ok4uw	2176	20	state	state	NN
cord-001835-0s7ok4uw	2176	21	of	of	IN
cord-001835-0s7ok4uw	2176	22	the	the	DT
cord-001835-0s7ok4uw	2176	23	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2176	24	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2176	25	,	,	,
cord-001835-0s7ok4uw	2176	26	and	and	CC
cord-001835-0s7ok4uw	2176	27	the	the	DT
cord-001835-0s7ok4uw	2176	28	sampled	sample	VBN
cord-001835-0s7ok4uw	2176	29	ensemble	ensemble	NN
cord-001835-0s7ok4uw	2176	30	of	of	IN
cord-001835-0s7ok4uw	2176	31	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2176	32	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	2176	33	.	.	.
cord-001835-0s7ok4uw	2177	1	Unfortunately	unfortunately	RB
cord-001835-0s7ok4uw	2177	2	,	,	,
cord-001835-0s7ok4uw	2177	3	fitting	fitting	JJ
cord-001835-0s7ok4uw	2177	4	of	of	IN
cord-001835-0s7ok4uw	2177	5	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	2177	6	models	model	NNS
cord-001835-0s7ok4uw	2177	7	to	to	IN
cord-001835-0s7ok4uw	2177	8	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2177	9	formation	formation	NN
cord-001835-0s7ok4uw	2177	10	kinetics	kinetics	NN
cord-001835-0s7ok4uw	2177	11	is	be	VBZ
cord-001835-0s7ok4uw	2177	12	an	an	DT
cord-001835-0s7ok4uw	2177	13	example	example	NN
cord-001835-0s7ok4uw	2177	14	of	of	IN
cord-001835-0s7ok4uw	2177	15	an	an	DT
cord-001835-0s7ok4uw	2177	16	"	"	``
cord-001835-0s7ok4uw	2177	17	ill	ill	RB
cord-001835-0s7ok4uw	2177	18	-	-	HYPH
cord-001835-0s7ok4uw	2177	19	posed	pose	VBN
cord-001835-0s7ok4uw	2177	20	problem	problem	NN
cord-001835-0s7ok4uw	2177	21	"	"	''
cord-001835-0s7ok4uw	2177	22	,	,	,
cord-001835-0s7ok4uw	2177	23	in	in	IN
cord-001835-0s7ok4uw	2177	24	that	that	DT
cord-001835-0s7ok4uw	2177	25	dramatically	dramatically	RB
cord-001835-0s7ok4uw	2177	26	different	different	JJ
cord-001835-0s7ok4uw	2177	27	combinations	combination	NNS
cord-001835-0s7ok4uw	2177	28	of	of	IN
cord-001835-0s7ok4uw	2177	29	elementary	elementary	JJ
cord-001835-0s7ok4uw	2177	30	parameters	parameter	NNS
cord-001835-0s7ok4uw	2177	31	can	can	MD
cord-001835-0s7ok4uw	2177	32	nevertheless	nevertheless	RB
cord-001835-0s7ok4uw	2177	33	generate	generate	VB
cord-001835-0s7ok4uw	2177	34	very	very	RB
cord-001835-0s7ok4uw	2177	35	similar	similar	JJ
cord-001835-0s7ok4uw	2177	36	sigmoidal	sigmoidal	JJ
cord-001835-0s7ok4uw	2177	37	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	2177	38	traces	trace	NNS
cord-001835-0s7ok4uw	2177	39	.	.	.
cord-001835-0s7ok4uw	2178	1	This	this	DT
cord-001835-0s7ok4uw	2178	2	has	have	VBZ
cord-001835-0s7ok4uw	2178	3	typically	typically	RB
cord-001835-0s7ok4uw	2178	4	necessitated	necessitate	VBN
cord-001835-0s7ok4uw	2178	5	global	global	JJ
cord-001835-0s7ok4uw	2178	6	analysis	analysis	NN
cord-001835-0s7ok4uw	2178	7	of	of	IN
cord-001835-0s7ok4uw	2178	8	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2178	9	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	2178	10	traces	trace	NNS
cord-001835-0s7ok4uw	2178	11	collected	collect	VBN
cord-001835-0s7ok4uw	2178	12	over	over	IN
cord-001835-0s7ok4uw	2178	13	a	a	DT
cord-001835-0s7ok4uw	2178	14	broad	broad	JJ
cord-001835-0s7ok4uw	2178	15	range	range	NN
cord-001835-0s7ok4uw	2178	16	of	of	IN
cord-001835-0s7ok4uw	2178	17	protein	protein	NN
cord-001835-0s7ok4uw	2178	18	concentrations	concentration	NNS
cord-001835-0s7ok4uw	2178	19	-a	-a	:
cord-001835-0s7ok4uw	2178	20	substantial	substantial	JJ
cord-001835-0s7ok4uw	2178	21	expenditure	expenditure	NN
cord-001835-0s7ok4uw	2178	22	of	of	IN
cord-001835-0s7ok4uw	2178	23	time	time	NN
cord-001835-0s7ok4uw	2178	24	,	,	,
cord-001835-0s7ok4uw	2178	25	effort	effort	NN
cord-001835-0s7ok4uw	2178	26	and	and	CC
cord-001835-0s7ok4uw	2178	27	material	material	NN
cord-001835-0s7ok4uw	2178	28	that	that	WDT
cord-001835-0s7ok4uw	2178	29	must	must	MD
cord-001835-0s7ok4uw	2178	30	then	then	RB
cord-001835-0s7ok4uw	2178	31	be	be	VB
cord-001835-0s7ok4uw	2178	32	repeated	repeat	VBN
cord-001835-0s7ok4uw	2178	33	in	in	IN
cord-001835-0s7ok4uw	2178	34	the	the	DT
cord-001835-0s7ok4uw	2178	35	presence	presence	NN
cord-001835-0s7ok4uw	2178	36	of	of	IN
cord-001835-0s7ok4uw	2178	37	a	a	DT
cord-001835-0s7ok4uw	2178	38	modulator	modulator	NN
cord-001835-0s7ok4uw	2178	39	in	in	IN
cord-001835-0s7ok4uw	2178	40	order	order	NN
cord-001835-0s7ok4uw	2178	41	to	to	TO
cord-001835-0s7ok4uw	2178	42	gain	gain	VB
cord-001835-0s7ok4uw	2178	43	insight	insight	NN
cord-001835-0s7ok4uw	2178	44	into	into	IN
cord-001835-0s7ok4uw	2178	45	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2178	46	effects	effect	NNS
cord-001835-0s7ok4uw	2178	47	.	.	.
cord-001835-0s7ok4uw	2179	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2179	2	propose	propose	VBP
cord-001835-0s7ok4uw	2179	3	an	an	DT
cord-001835-0s7ok4uw	2179	4	alternative	alternative	JJ
cord-001835-0s7ok4uw	2179	5	approach	approach	NN
cord-001835-0s7ok4uw	2179	6	:	:	:
cord-001835-0s7ok4uw	2179	7	to	to	TO
cord-001835-0s7ok4uw	2179	8	fit	fit	VB
cord-001835-0s7ok4uw	2179	9	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2179	10	formation	formation	NN
cord-001835-0s7ok4uw	2179	11	traces	trace	VBZ
cord-001835-0s7ok4uw	2179	12	to	to	IN
cord-001835-0s7ok4uw	2179	13	a	a	DT
cord-001835-0s7ok4uw	2179	14	large	large	JJ
cord-001835-0s7ok4uw	2179	15	distribution	distribution	NN
cord-001835-0s7ok4uw	2179	16	of	of	IN
cord-001835-0s7ok4uw	2179	17	parameter	parameter	NN
cord-001835-0s7ok4uw	2179	18	sets	set	NNS
cord-001835-0s7ok4uw	2179	19	,	,	,
cord-001835-0s7ok4uw	2179	20	and	and	CC
cord-001835-0s7ok4uw	2179	21	determine	determine	VB
cord-001835-0s7ok4uw	2179	22	how	how	WRB
cord-001835-0s7ok4uw	2179	23	various	various	JJ
cord-001835-0s7ok4uw	2179	24	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2179	25	modulators	modulator	NNS
cord-001835-0s7ok4uw	2179	26	affect	affect	VBP
cord-001835-0s7ok4uw	2179	27	the	the	DT
cord-001835-0s7ok4uw	2179	28	distribution	distribution	NN
cord-001835-0s7ok4uw	2179	29	of	of	IN
cord-001835-0s7ok4uw	2179	30	parameters	parameter	NNS
cord-001835-0s7ok4uw	2179	31	.	.	.
cord-001835-0s7ok4uw	2180	1	This	this	DT
cord-001835-0s7ok4uw	2180	2	socalled	socalled	JJ
cord-001835-0s7ok4uw	2180	3	"	"	``
cord-001835-0s7ok4uw	2180	4	parameter	parameter	NN
cord-001835-0s7ok4uw	2180	5	distribution	distribution	NN
cord-001835-0s7ok4uw	2180	6	analysis	analysis	NN
cord-001835-0s7ok4uw	2180	7	"	"	''
cord-001835-0s7ok4uw	2180	8	enables	enable	VBZ
cord-001835-0s7ok4uw	2180	9	the	the	DT
cord-001835-0s7ok4uw	2180	10	inference	inference	NN
cord-001835-0s7ok4uw	2180	11	of	of	IN
cord-001835-0s7ok4uw	2180	12	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	2180	13	effects	effect	NNS
cord-001835-0s7ok4uw	2180	14	from	from	IN
cord-001835-0s7ok4uw	2180	15	measurements	measurement	NNS
cord-001835-0s7ok4uw	2180	16	at	at	IN
cord-001835-0s7ok4uw	2180	17	a	a	DT
cord-001835-0s7ok4uw	2180	18	single	single	JJ
cord-001835-0s7ok4uw	2180	19	protein	protein	NN
cord-001835-0s7ok4uw	2180	20	concentration	concentration	NN
cord-001835-0s7ok4uw	2180	21	.	.	.
cord-001835-0s7ok4uw	2181	1	Parameter	parameter	NN
cord-001835-0s7ok4uw	2181	2	distribution	distribution	NN
cord-001835-0s7ok4uw	2181	3	analysis	analysis	NN
cord-001835-0s7ok4uw	2181	4	based	base	VBN
cord-001835-0s7ok4uw	2181	5	on	on	IN
cord-001835-0s7ok4uw	2181	6	numerical	numerical	JJ
cord-001835-0s7ok4uw	2181	7	modeling	modeling	NN
cord-001835-0s7ok4uw	2181	8	has	have	VBZ
cord-001835-0s7ok4uw	2181	9	been	be	VBN
cord-001835-0s7ok4uw	2181	10	made	make	VBN
cord-001835-0s7ok4uw	2181	11	tractable	tractable	JJ
cord-001835-0s7ok4uw	2181	12	by	by	IN
cord-001835-0s7ok4uw	2181	13	advances	advance	NNS
cord-001835-0s7ok4uw	2181	14	in	in	IN
cord-001835-0s7ok4uw	2181	15	computer	computer	NN
cord-001835-0s7ok4uw	2181	16	hardware	hardware	NN
cord-001835-0s7ok4uw	2181	17	and	and	CC
cord-001835-0s7ok4uw	2181	18	software	software	NN
cord-001835-0s7ok4uw	2181	19	,	,	,
cord-001835-0s7ok4uw	2181	20	and	and	CC
cord-001835-0s7ok4uw	2181	21	can	can	MD
cord-001835-0s7ok4uw	2181	22	be	be	VB
cord-001835-0s7ok4uw	2181	23	easily	easily	RB
cord-001835-0s7ok4uw	2181	24	extended	extend	VBN
cord-001835-0s7ok4uw	2181	25	to	to	TO
cord-001835-0s7ok4uw	2181	26	include	include	VB
cord-001835-0s7ok4uw	2181	27	additional	additional	JJ
cord-001835-0s7ok4uw	2181	28	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	2181	29	or	or	CC
cord-001835-0s7ok4uw	2181	30	phases	phase	NNS
cord-001835-0s7ok4uw	2181	31	relevant	relevant	JJ
cord-001835-0s7ok4uw	2181	32	to	to	IN
cord-001835-0s7ok4uw	2181	33	a	a	DT
cord-001835-0s7ok4uw	2181	34	protein	protein	NN
cord-001835-0s7ok4uw	2181	35	or	or	CC
cord-001835-0s7ok4uw	2181	36	modulator	modulator	NN
cord-001835-0s7ok4uw	2181	37	of	of	IN
cord-001835-0s7ok4uw	2181	38	interest	interest	NN
cord-001835-0s7ok4uw	2181	39	.	.	.
cord-001835-0s7ok4uw	2182	1	Here	here	RB
cord-001835-0s7ok4uw	2182	2	,	,	,
cord-001835-0s7ok4uw	2182	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2182	4	illustrate	illustrate	VBP
cord-001835-0s7ok4uw	2182	5	how	how	WRB
cord-001835-0s7ok4uw	2182	6	parameter	parameter	NN
cord-001835-0s7ok4uw	2182	7	distribution	distribution	NN
cord-001835-0s7ok4uw	2182	8	analysis	analysis	NN
cord-001835-0s7ok4uw	2182	9	,	,	,
cord-001835-0s7ok4uw	2182	10	complemented	complement	VBN
cord-001835-0s7ok4uw	2182	11	by	by	IN
cord-001835-0s7ok4uw	2182	12	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2182	13	correlation	correlation	NN
cord-001835-0s7ok4uw	2182	14	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2182	15	(	(	-LRB-
cord-001835-0s7ok4uw	2182	16	FCS	FCS	NNP
cord-001835-0s7ok4uw	2182	17	)	)	-RRB-
cord-001835-0s7ok4uw	2182	18	,	,	,
cord-001835-0s7ok4uw	2182	19	electron	electron	NN
cord-001835-0s7ok4uw	2182	20	microscopy	microscopy	NN
cord-001835-0s7ok4uw	2182	21	(	(	-LRB-
cord-001835-0s7ok4uw	2182	22	EM	EM	NNP
cord-001835-0s7ok4uw	2182	23	)	)	-RRB-
cord-001835-0s7ok4uw	2182	24	and	and	CC
cord-001835-0s7ok4uw	2182	25	other	other	JJ
cord-001835-0s7ok4uw	2182	26	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	2182	27	techniques	technique	NNS
cord-001835-0s7ok4uw	2182	28	,	,	,
cord-001835-0s7ok4uw	2182	29	can	can	MD
cord-001835-0s7ok4uw	2182	30	shed	shed	VB
cord-001835-0s7ok4uw	2182	31	light	light	NN
cord-001835-0s7ok4uw	2182	32	on	on	IN
cord-001835-0s7ok4uw	2182	33	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	2182	34	aspects	aspect	NNS
cord-001835-0s7ok4uw	2182	35	of	of	IN
cord-001835-0s7ok4uw	2182	36	tau	tau	NNP
cord-001835-0s7ok4uw	2182	37	amyloidogenesis	amyloidogenesis	NNP
cord-001835-0s7ok4uw	2182	38	.	.	.
cord-001835-0s7ok4uw	2183	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2183	2	examine	examine	VBP
cord-001835-0s7ok4uw	2183	3	the	the	DT
cord-001835-0s7ok4uw	2183	4	disparate	disparate	JJ
cord-001835-0s7ok4uw	2183	5	effects	effect	NNS
cord-001835-0s7ok4uw	2183	6	that	that	WDT
cord-001835-0s7ok4uw	2183	7	natural	natural	JJ
cord-001835-0s7ok4uw	2183	8	products	product	NNS
cord-001835-0s7ok4uw	2183	9	,	,	,
cord-001835-0s7ok4uw	2183	10	pharmacotherapies	pharmacotherapie	NNS
cord-001835-0s7ok4uw	2183	11	and	and	CC
cord-001835-0s7ok4uw	2183	12	protein	protein	NN
cord-001835-0s7ok4uw	2183	13	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	2183	14	can	can	MD
cord-001835-0s7ok4uw	2183	15	have	have	VB
cord-001835-0s7ok4uw	2183	16	on	on	IN
cord-001835-0s7ok4uw	2183	17	the	the	DT
cord-001835-0s7ok4uw	2183	18	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2183	19	of	of	IN
cord-001835-0s7ok4uw	2183	20	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2183	21	,	,	,
cord-001835-0s7ok4uw	2183	22	and	and	CC
cord-001835-0s7ok4uw	2183	23	also	also	RB
cord-001835-0s7ok4uw	2183	24	discuss	discuss	VB
cord-001835-0s7ok4uw	2183	25	the	the	DT
cord-001835-0s7ok4uw	2183	26	effects	effect	NNS
cord-001835-0s7ok4uw	2183	27	of	of	IN
cord-001835-0s7ok4uw	2183	28	heparin	heparin	NN
cord-001835-0s7ok4uw	2183	29	(	(	-LRB-
cord-001835-0s7ok4uw	2183	30	widely	widely	RB
cord-001835-0s7ok4uw	2183	31	used	use	VBN
cord-001835-0s7ok4uw	2183	32	as	as	IN
cord-001835-0s7ok4uw	2183	33	an	an	DT
cord-001835-0s7ok4uw	2183	34	inducer	inducer	NN
cord-001835-0s7ok4uw	2183	35	of	of	IN
cord-001835-0s7ok4uw	2183	36	tau	tau	NNP
cord-001835-0s7ok4uw	2183	37	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2183	38	)	)	-RRB-
cord-001835-0s7ok4uw	2183	39	.	.	.
cord-001835-0s7ok4uw	2184	1	These	these	DT
cord-001835-0s7ok4uw	2184	2	insights	insight	NNS
cord-001835-0s7ok4uw	2184	3	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	2184	4	the	the	DT
cord-001835-0s7ok4uw	2184	5	value	value	NN
cord-001835-0s7ok4uw	2184	6	of	of	IN
cord-001835-0s7ok4uw	2184	7	parameter	parameter	NN
cord-001835-0s7ok4uw	2184	8	distribution	distribution	NN
cord-001835-0s7ok4uw	2184	9	analysis	analysis	NN
cord-001835-0s7ok4uw	2184	10	as	as	IN
cord-001835-0s7ok4uw	2184	11	applied	apply	VBN
cord-001835-0s7ok4uw	2184	12	to	to	IN
cord-001835-0s7ok4uw	2184	13	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2184	14	formation	formation	NN
cord-001835-0s7ok4uw	2184	15	and	and	CC
cord-001835-0s7ok4uw	2184	16	other	other	JJ
cord-001835-0s7ok4uw	2184	17	ill	ill	RB
cord-001835-0s7ok4uw	2184	18	-	-	HYPH
cord-001835-0s7ok4uw	2184	19	posed	pose	VBN
cord-001835-0s7ok4uw	2184	20	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	2184	21	problems	problem	NNS
cord-001835-0s7ok4uw	2184	22	.	.	.
cord-001835-0s7ok4uw	2185	1	New	new	JJ
cord-001835-0s7ok4uw	2185	2	insights	insight	NNS
cord-001835-0s7ok4uw	2185	3	into	into	IN
cord-001835-0s7ok4uw	2185	4	amyloidogenesis	amyloidogenesis	NN
cord-001835-0s7ok4uw	2185	5	of	of	IN
cord-001835-0s7ok4uw	2185	6	Tau	Tau	NNP
cord-001835-0s7ok4uw	2185	7	protein	protein	NN
cord-001835-0s7ok4uw	2185	8	induced	induce	VBN
cord-001835-0s7ok4uw	2185	9	by	by	IN
cord-001835-0s7ok4uw	2185	10	enantiomers	enantiomer	NNS
cord-001835-0s7ok4uw	2185	11	of	of	IN
cord-001835-0s7ok4uw	2185	12	polyglutamic	polyglutamic	JJ
cord-001835-0s7ok4uw	2185	13	acid	acid	NN
cord-001835-0s7ok4uw	2185	14	Amyloidogenesis	Amyloidogenesis	NNP
cord-001835-0s7ok4uw	2185	15	of	of	IN
cord-001835-0s7ok4uw	2185	16	Tau	Tau	NNP
cord-001835-0s7ok4uw	2185	17	protein	protein	NN
cord-001835-0s7ok4uw	2185	18	leads	lead	VBZ
cord-001835-0s7ok4uw	2185	19	to	to	IN
cord-001835-0s7ok4uw	2185	20	the	the	DT
cord-001835-0s7ok4uw	2185	21	formation	formation	NN
cord-001835-0s7ok4uw	2185	22	of	of	IN
cord-001835-0s7ok4uw	2185	23	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2185	24	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2185	25	(	(	-LRB-
cord-001835-0s7ok4uw	2185	26	ordered	order	VBN
cord-001835-0s7ok4uw	2185	27	fibrillar	fibrillar	NNP
cord-001835-0s7ok4uw	2185	28	protein	protein	NN
cord-001835-0s7ok4uw	2185	29	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	2185	30	)	)	-RRB-
cord-001835-0s7ok4uw	2185	31	which	which	WDT
cord-001835-0s7ok4uw	2185	32	are	be	VBP
cord-001835-0s7ok4uw	2185	33	accumulated	accumulate	VBN
cord-001835-0s7ok4uw	2185	34	in	in	IN
cord-001835-0s7ok4uw	2185	35	neurons	neuron	NNS
cord-001835-0s7ok4uw	2185	36	of	of	IN
cord-001835-0s7ok4uw	2185	37	central	central	JJ
cord-001835-0s7ok4uw	2185	38	nervous	nervous	JJ
cord-001835-0s7ok4uw	2185	39	system	system	NN
cord-001835-0s7ok4uw	2185	40	during	during	IN
cord-001835-0s7ok4uw	2185	41	the	the	DT
cord-001835-0s7ok4uw	2185	42	course	course	NN
cord-001835-0s7ok4uw	2185	43	of	of	IN
cord-001835-0s7ok4uw	2185	44	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	2185	45	diseases	disease	NNS
cord-001835-0s7ok4uw	2185	46	called	call	VBN
cord-001835-0s7ok4uw	2185	47	tauopathies	tauopathie	NNS
cord-001835-0s7ok4uw	2185	48	.	.	.
cord-001835-0s7ok4uw	2186	1	Studying	study	VBG
cord-001835-0s7ok4uw	2186	2	Tau	Tau	NNP
cord-001835-0s7ok4uw	2186	3	(	(	-LRB-
cord-001835-0s7ok4uw	2186	4	a	a	DT
cord-001835-0s7ok4uw	2186	5	typical	typical	JJ
cord-001835-0s7ok4uw	2186	6	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2186	7	disordered	disordered	JJ
cord-001835-0s7ok4uw	2186	8	protein	protein	NN
cord-001835-0s7ok4uw	2186	9	)	)	-RRB-
cord-001835-0s7ok4uw	2186	10	amyloidogenesis	amyloidogenesis	NNP
cord-001835-0s7ok4uw	2186	11	has	have	VBZ
cord-001835-0s7ok4uw	2186	12	been	be	VBN
cord-001835-0s7ok4uw	2186	13	challenging	challenge	VBG
cord-001835-0s7ok4uw	2186	14	for	for	IN
cord-001835-0s7ok4uw	2186	15	many	many	JJ
cord-001835-0s7ok4uw	2186	16	reasons	reason	NNS
cord-001835-0s7ok4uw	2186	17	.	.	.
cord-001835-0s7ok4uw	2187	1	Positive	positive	JJ
cord-001835-0s7ok4uw	2187	2	charge	charge	NN
cord-001835-0s7ok4uw	2187	3	on	on	IN
cord-001835-0s7ok4uw	2187	4	the	the	DT
cord-001835-0s7ok4uw	2187	5	Tau	Tau	NNP
cord-001835-0s7ok4uw	2187	6	molecule	molecule	NN
cord-001835-0s7ok4uw	2187	7	must	must	MD
cord-001835-0s7ok4uw	2187	8	be	be	VB
cord-001835-0s7ok4uw	2187	9	compensated	compensate	VBN
cord-001835-0s7ok4uw	2187	10	(	(	-LRB-
cord-001835-0s7ok4uw	2187	11	e.g.	e.g.	RB
cord-001835-0s7ok4uw	2187	12	in	in	IN
cord-001835-0s7ok4uw	2187	13	the	the	DT
cord-001835-0s7ok4uw	2187	14	presence	presence	NN
cord-001835-0s7ok4uw	2187	15	of	of	IN
cord-001835-0s7ok4uw	2187	16	polyanions	polyanion	NNS
cord-001835-0s7ok4uw	2187	17	)	)	-RRB-
cord-001835-0s7ok4uw	2187	18	in	in	IN
cord-001835-0s7ok4uw	2187	19	order	order	NN
cord-001835-0s7ok4uw	2187	20	to	to	TO
cord-001835-0s7ok4uw	2187	21	initiate	initiate	VB
cord-001835-0s7ok4uw	2187	22	the	the	DT
cord-001835-0s7ok4uw	2187	23	process	process	NN
cord-001835-0s7ok4uw	2187	24	.	.	.
cord-001835-0s7ok4uw	2188	1	Heparin	Heparin	NNP
cord-001835-0s7ok4uw	2188	2	(	(	-LRB-
cord-001835-0s7ok4uw	2188	3	glycosaminoglycan	glycosaminoglycan	NNP
cord-001835-0s7ok4uw	2188	4	)	)	-RRB-
cord-001835-0s7ok4uw	2188	5	has	have	VBZ
cord-001835-0s7ok4uw	2188	6	been	be	VBN
cord-001835-0s7ok4uw	2188	7	the	the	DT
cord-001835-0s7ok4uw	2188	8	most	most	RBS
cord-001835-0s7ok4uw	2188	9	intensively	intensively	RB
cord-001835-0s7ok4uw	2188	10	studied	study	VBN
cord-001835-0s7ok4uw	2188	11	charge	charge	NN
cord-001835-0s7ok4uw	2188	12	-	-	HYPH
cord-001835-0s7ok4uw	2188	13	compensating	compensate	VBG
cord-001835-0s7ok4uw	2188	14	agent	agent	NN
cord-001835-0s7ok4uw	2188	15	in	in	IN
cord-001835-0s7ok4uw	2188	16	this	this	DT
cord-001835-0s7ok4uw	2188	17	context	context	NN
cord-001835-0s7ok4uw	2188	18	.	.	.
cord-001835-0s7ok4uw	2189	1	On	on	IN
cord-001835-0s7ok4uw	2189	2	the	the	DT
cord-001835-0s7ok4uw	2189	3	other	other	JJ
cord-001835-0s7ok4uw	2189	4	hand	hand	NN
cord-001835-0s7ok4uw	2189	5	induction	induction	NN
cord-001835-0s7ok4uw	2189	6	of	of	IN
cord-001835-0s7ok4uw	2189	7	Tau	Tau	NNP
cord-001835-0s7ok4uw	2189	8	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2189	9	by	by	IN
cord-001835-0s7ok4uw	2189	10	polyglutamic	polyglutamic	JJ
cord-001835-0s7ok4uw	2189	11	acid	acid	NN
cord-001835-0s7ok4uw	2189	12	is	be	VBZ
cord-001835-0s7ok4uw	2189	13	poorly	poorly	RB
cord-001835-0s7ok4uw	2189	14	characterized	characterize	VBN
cord-001835-0s7ok4uw	2189	15	.	.	.
cord-001835-0s7ok4uw	2190	1	Mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	2190	2	responsible	responsible	JJ
cord-001835-0s7ok4uw	2190	3	for	for	IN
cord-001835-0s7ok4uw	2190	4	the	the	DT
cord-001835-0s7ok4uw	2190	5	propagation	propagation	NN
cord-001835-0s7ok4uw	2190	6	of	of	IN
cord-001835-0s7ok4uw	2190	7	Tau	Tau	NNP
cord-001835-0s7ok4uw	2190	8	conformations	conformation	NNS
cord-001835-0s7ok4uw	2190	9	has	have	VBZ
cord-001835-0s7ok4uw	2190	10	become	become	VBN
cord-001835-0s7ok4uw	2190	11	an	an	DT
cord-001835-0s7ok4uw	2190	12	interesting	interesting	JJ
cord-001835-0s7ok4uw	2190	13	research	research	NN
cord-001835-0s7ok4uw	2190	14	objective	objective	NN
cord-001835-0s7ok4uw	2190	15	.	.	.
cord-001835-0s7ok4uw	2191	1	Prion	prion	NN
cord-001835-0s7ok4uw	2191	2	-	-	HYPH
cord-001835-0s7ok4uw	2191	3	like	like	JJ
cord-001835-0s7ok4uw	2191	4	features	feature	NNS
cord-001835-0s7ok4uw	2191	5	of	of	IN
cord-001835-0s7ok4uw	2191	6	Tau	Tau	NNP
cord-001835-0s7ok4uw	2191	7	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2191	8	can	can	MD
cord-001835-0s7ok4uw	2191	9	be	be	VB
cord-001835-0s7ok4uw	2191	10	studied	study	VBN
cord-001835-0s7ok4uw	2191	11	in	in	IN
cord-001835-0s7ok4uw	2191	12	vitro	vitro	FW
cord-001835-0s7ok4uw	2191	13	also	also	RB
cord-001835-0s7ok4uw	2191	14	in	in	IN
cord-001835-0s7ok4uw	2191	15	the	the	DT
cord-001835-0s7ok4uw	2191	16	seed	seed	NN
cord-001835-0s7ok4uw	2191	17	-	-	HYPH
cord-001835-0s7ok4uw	2191	18	induced	induce	VBN
cord-001835-0s7ok4uw	2191	19	regime	regime	NN
cord-001835-0s7ok4uw	2191	20	of	of	IN
cord-001835-0s7ok4uw	2191	21	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2191	22	.	.	.
cord-001835-0s7ok4uw	2192	1	Tau	Tau	NNP
cord-001835-0s7ok4uw	2192	2	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2192	3	seeds	seed	NNS
cord-001835-0s7ok4uw	2192	4	can	can	MD
cord-001835-0s7ok4uw	2192	5	act	act	VB
cord-001835-0s7ok4uw	2192	6	as	as	IN
cord-001835-0s7ok4uw	2192	7	nuclei	nucleus	NNS
cord-001835-0s7ok4uw	2192	8	for	for	IN
cord-001835-0s7ok4uw	2192	9	amyloidogenesis	amyloidogenesis	NN
cord-001835-0s7ok4uw	2192	10	.	.	.
cord-001835-0s7ok4uw	2193	1	Such	such	JJ
cord-001835-0s7ok4uw	2193	2	seeds	seed	NNS
cord-001835-0s7ok4uw	2193	3	can	can	MD
cord-001835-0s7ok4uw	2193	4	be	be	VB
cord-001835-0s7ok4uw	2193	5	obtained	obtain	VBN
cord-001835-0s7ok4uw	2193	6	by	by	IN
cord-001835-0s7ok4uw	2193	7	fragmentation	fragmentation	NN
cord-001835-0s7ok4uw	2193	8	of	of	IN
cord-001835-0s7ok4uw	2193	9	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2193	10	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2193	11	by	by	IN
cord-001835-0s7ok4uw	2193	12	means	mean	NNS
cord-001835-0s7ok4uw	2193	13	of	of	IN
cord-001835-0s7ok4uw	2193	14	sonication	sonication	NN
cord-001835-0s7ok4uw	2193	15	.	.	.
cord-001835-0s7ok4uw	2194	1	Given	give	VBN
cord-001835-0s7ok4uw	2194	2	that	that	DT
cord-001835-0s7ok4uw	2194	3	amyloidogenesis	amyloidogenesis	NN
cord-001835-0s7ok4uw	2194	4	can	can	MD
cord-001835-0s7ok4uw	2194	5	proceed	proceed	VB
cord-001835-0s7ok4uw	2194	6	through	through	IN
cord-001835-0s7ok4uw	2194	7	various	various	JJ
cord-001835-0s7ok4uw	2194	8	assembly	assembly	NN
cord-001835-0s7ok4uw	2194	9	pathways	pathway	NNS
cord-001835-0s7ok4uw	2194	10	resulting	result	VBG
cord-001835-0s7ok4uw	2194	11	in	in	IN
cord-001835-0s7ok4uw	2194	12	distinct	distinct	JJ
cord-001835-0s7ok4uw	2194	13	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2194	14	'	'	``
cord-001835-0s7ok4uw	2194	15	strains	strain	NNS
cord-001835-0s7ok4uw	2194	16	'	'	''
cord-001835-0s7ok4uw	2194	17	(	(	-LRB-
cord-001835-0s7ok4uw	2194	18	self	self	NN
cord-001835-0s7ok4uw	2194	19	-	-	HYPH
cord-001835-0s7ok4uw	2194	20	propagating	propagate	VBG
cord-001835-0s7ok4uw	2194	21	structural	structural	JJ
cord-001835-0s7ok4uw	2194	22	variants	variant	NNS
cord-001835-0s7ok4uw	2194	23	of	of	IN
cord-001835-0s7ok4uw	2194	24	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2194	25	)	)	-RRB-
cord-001835-0s7ok4uw	2194	26	we	-PRON-	PRP
cord-001835-0s7ok4uw	2194	27	have	have	VBP
cord-001835-0s7ok4uw	2194	28	used	use	VBN
cord-001835-0s7ok4uw	2194	29	poly	poly	NNP
cord-001835-0s7ok4uw	2194	30	-	-	HYPH
cord-001835-0s7ok4uw	2194	31	L	l	NN
cord-001835-0s7ok4uw	2194	32	-	-	HYPH
cord-001835-0s7ok4uw	2194	33	glutamic	glutamic	NN
cord-001835-0s7ok4uw	2194	34	acid	acid	NN
cord-001835-0s7ok4uw	2194	35	(	(	-LRB-
cord-001835-0s7ok4uw	2194	36	PLGA	PLGA	NNP
cord-001835-0s7ok4uw	2194	37	)	)	-RRB-
cord-001835-0s7ok4uw	2194	38	and	and	CC
cord-001835-0s7ok4uw	2194	39	poly	poly	JJ
cord-001835-0s7ok4uw	2194	40	-	-	HYPH
cord-001835-0s7ok4uw	2194	41	D	d	JJ
cord-001835-0s7ok4uw	2194	42	-	-	HYPH
cord-001835-0s7ok4uw	2194	43	glutamic	glutamic	NN
cord-001835-0s7ok4uw	2194	44	acid	acid	NN
cord-001835-0s7ok4uw	2194	45	(	(	-LRB-
cord-001835-0s7ok4uw	2194	46	PDGA	PDGA	NNP
cord-001835-0s7ok4uw	2194	47	)	)	-RRB-
cord-001835-0s7ok4uw	2194	48	to	to	TO
cord-001835-0s7ok4uw	2194	49	direct	direct	VB
cord-001835-0s7ok4uw	2194	50	Tau	Tau	NNP
cord-001835-0s7ok4uw	2194	51	onto	onto	IN
cord-001835-0s7ok4uw	2194	52	different	different	JJ
cord-001835-0s7ok4uw	2194	53	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	2194	54	pathways	pathway	NNS
cord-001835-0s7ok4uw	2194	55	.	.	.
cord-001835-0s7ok4uw	2195	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2195	2	have	have	VBP
cord-001835-0s7ok4uw	2195	3	hypothesized	hypothesize	VBN
cord-001835-0s7ok4uw	2195	4	that	that	IN
cord-001835-0s7ok4uw	2195	5	the	the	DT
cord-001835-0s7ok4uw	2195	6	chirality	chirality	NN
cord-001835-0s7ok4uw	2195	7	of	of	IN
cord-001835-0s7ok4uw	2195	8	the	the	DT
cord-001835-0s7ok4uw	2195	9	inducers	inducer	NNS
cord-001835-0s7ok4uw	2195	10	could	could	MD
cord-001835-0s7ok4uw	2195	11	lead	lead	VB
cord-001835-0s7ok4uw	2195	12	to	to	IN
cord-001835-0s7ok4uw	2195	13	fibril	fibril	NNP
cord-001835-0s7ok4uw	2195	14	polymorphism	polymorphism	NN
cord-001835-0s7ok4uw	2195	15	.	.	.
cord-001835-0s7ok4uw	2196	1	In	in	IN
cord-001835-0s7ok4uw	2196	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2196	3	studies	study	NNS
cord-001835-0s7ok4uw	2196	4	,	,	,
cord-001835-0s7ok4uw	2196	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2196	6	have	have	VBP
cord-001835-0s7ok4uw	2196	7	used	use	VBN
cord-001835-0s7ok4uw	2196	8	a	a	DT
cord-001835-0s7ok4uw	2196	9	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	2196	10	human	human	JJ
cord-001835-0s7ok4uw	2196	11	2N4R	2n4r	CD
cord-001835-0s7ok4uw	2196	12	Tau	Tau	NNP
cord-001835-0s7ok4uw	2196	13	isoform	isoform	NN
cord-001835-0s7ok4uw	2196	14	.	.	.
cord-001835-0s7ok4uw	2197	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2197	2	have	have	VBP
cord-001835-0s7ok4uw	2197	3	been	be	VBN
cord-001835-0s7ok4uw	2197	4	using	use	VBG
cord-001835-0s7ok4uw	2197	5	transmission	transmission	NN
cord-001835-0s7ok4uw	2197	6	electron	electron	NN
cord-001835-0s7ok4uw	2197	7	microscopy	microscopy	NN
cord-001835-0s7ok4uw	2197	8	(	(	-LRB-
cord-001835-0s7ok4uw	2197	9	TEM	TEM	NNP
cord-001835-0s7ok4uw	2197	10	)	)	-RRB-
cord-001835-0s7ok4uw	2197	11	,	,	,
cord-001835-0s7ok4uw	2197	12	sedimentation	sedimentation	NN
cord-001835-0s7ok4uw	2197	13	and	and	CC
cord-001835-0s7ok4uw	2197	14	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	2197	15	measurment	measurment	NN
cord-001835-0s7ok4uw	2197	16	.	.	.
cord-001835-0s7ok4uw	2198	1	Firstly	firstly	RB
cord-001835-0s7ok4uw	2198	2	,	,	,
cord-001835-0s7ok4uw	2198	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2198	4	have	have	VBP
cord-001835-0s7ok4uw	2198	5	characterized	characterize	VBN
cord-001835-0s7ok4uw	2198	6	unseeded	unseeded	JJ
cord-001835-0s7ok4uw	2198	7	PLGA-/PDGA	PLGA-/PDGA	NNP
cord-001835-0s7ok4uw	2198	8	-	-	HYPH
cord-001835-0s7ok4uw	2198	9	induced	induce	VBN
cord-001835-0s7ok4uw	2198	10	Tau	Tau	NNP
cord-001835-0s7ok4uw	2198	11	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2198	12	to	to	TO
cord-001835-0s7ok4uw	2198	13	find	find	VB
cord-001835-0s7ok4uw	2198	14	out	out	RP
cord-001835-0s7ok4uw	2198	15	that	that	IN
cord-001835-0s7ok4uw	2198	16	corresponding	correspond	VBG
cord-001835-0s7ok4uw	2198	17	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2198	18	were	be	VBD
cord-001835-0s7ok4uw	2198	19	significantly	significantly	RB
cord-001835-0s7ok4uw	2198	20	different	different	JJ
cord-001835-0s7ok4uw	2198	21	.	.	.
cord-001835-0s7ok4uw	2199	1	Secondly	secondly	RB
cord-001835-0s7ok4uw	2199	2	,	,	,
cord-001835-0s7ok4uw	2199	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2199	4	have	have	VBP
cord-001835-0s7ok4uw	2199	5	used	use	VBN
cord-001835-0s7ok4uw	2199	6	sonicated	sonicate	VBN
cord-001835-0s7ok4uw	2199	7	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2199	8	to	to	TO
cord-001835-0s7ok4uw	2199	9	characterize	characterize	VB
cord-001835-0s7ok4uw	2199	10	the	the	DT
cord-001835-0s7ok4uw	2199	11	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2199	12	of	of	IN
cord-001835-0s7ok4uw	2199	13	seeded	seeded	JJ
cord-001835-0s7ok4uw	2199	14	processes	process	NNS
cord-001835-0s7ok4uw	2199	15	.	.	.
cord-001835-0s7ok4uw	2200	1	Both	both	DT
cord-001835-0s7ok4uw	2200	2	PLGA-/PDGA	PLGA-/PDGA	NNP
cord-001835-0s7ok4uw	2200	3	-	-	HYPH
cord-001835-0s7ok4uw	2200	4	induced	induce	VBN
cord-001835-0s7ok4uw	2200	5	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2200	6	seeds	seed	NNS
cord-001835-0s7ok4uw	2200	7	were	be	VBD
cord-001835-0s7ok4uw	2200	8	able	able	JJ
cord-001835-0s7ok4uw	2200	9	to	to	TO
cord-001835-0s7ok4uw	2200	10	efficiently	efficiently	RB
cord-001835-0s7ok4uw	2200	11	seed	seed	VB
cord-001835-0s7ok4uw	2200	12	Tau	Tau	NNP
cord-001835-0s7ok4uw	2200	13	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2200	14	in	in	IN
cord-001835-0s7ok4uw	2200	15	the	the	DT
cord-001835-0s7ok4uw	2200	16	presence	presence	NN
cord-001835-0s7ok4uw	2200	17	of	of	IN
cord-001835-0s7ok4uw	2200	18	PLGA	PLGA	NNP
cord-001835-0s7ok4uw	2200	19	,	,	,
cord-001835-0s7ok4uw	2200	20	whereas	whereas	IN
cord-001835-0s7ok4uw	2200	21	in	in	IN
cord-001835-0s7ok4uw	2200	22	the	the	DT
cord-001835-0s7ok4uw	2200	23	presence	presence	NN
cord-001835-0s7ok4uw	2200	24	of	of	IN
cord-001835-0s7ok4uw	2200	25	PDGA	PDGA	NNP
cord-001835-0s7ok4uw	2200	26	the	the	DT
cord-001835-0s7ok4uw	2200	27	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2200	28	was	be	VBD
cord-001835-0s7ok4uw	2200	29	much	much	RB
cord-001835-0s7ok4uw	2200	30	less	less	RBR
cord-001835-0s7ok4uw	2200	31	effective	effective	JJ
cord-001835-0s7ok4uw	2200	32	.	.	.
cord-001835-0s7ok4uw	2201	1	Surprisingly	surprisingly	RB
cord-001835-0s7ok4uw	2201	2	,	,	,
cord-001835-0s7ok4uw	2201	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2201	4	found	find	VBD
cord-001835-0s7ok4uw	2201	5	that	that	IN
cord-001835-0s7ok4uw	2201	6	PDGAinduced	pdgainduce	VBN
cord-001835-0s7ok4uw	2201	7	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2201	8	seeds	seed	NNS
cord-001835-0s7ok4uw	2201	9	were	be	VBD
cord-001835-0s7ok4uw	2201	10	able	able	JJ
cord-001835-0s7ok4uw	2201	11	to	to	TO
cord-001835-0s7ok4uw	2201	12	catalyze	catalyze	VB
cord-001835-0s7ok4uw	2201	13	fibrillogenesis	fibrillogenesi	NNS
cord-001835-0s7ok4uw	2201	14	of	of	IN
cord-001835-0s7ok4uw	2201	15	Tau	Tau	NNP
cord-001835-0s7ok4uw	2201	16	more	more	RBR
cord-001835-0s7ok4uw	2201	17	clearly	clearly	RB
cord-001835-0s7ok4uw	2201	18	in	in	IN
cord-001835-0s7ok4uw	2201	19	the	the	DT
cord-001835-0s7ok4uw	2201	20	presence	presence	NN
cord-001835-0s7ok4uw	2201	21	of	of	IN
cord-001835-0s7ok4uw	2201	22	soluble	soluble	JJ
cord-001835-0s7ok4uw	2201	23	PLGA	PLGA	NNP
cord-001835-0s7ok4uw	2201	24	than	than	IN
cord-001835-0s7ok4uw	2201	25	in	in	IN
cord-001835-0s7ok4uw	2201	26	the	the	DT
cord-001835-0s7ok4uw	2201	27	presence	presence	NN
cord-001835-0s7ok4uw	2201	28	of	of	IN
cord-001835-0s7ok4uw	2201	29	PDGA	PDGA	NNP
cord-001835-0s7ok4uw	2201	30	-the	-the	DT
cord-001835-0s7ok4uw	2201	31	primary	primary	JJ
cord-001835-0s7ok4uw	2201	32	inducer	inducer	NN
cord-001835-0s7ok4uw	2201	33	.	.	.
cord-001835-0s7ok4uw	2202	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2202	2	could	could	MD
cord-001835-0s7ok4uw	2202	3	not	not	RB
cord-001835-0s7ok4uw	2202	4	induce	induce	VB
cord-001835-0s7ok4uw	2202	5	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2202	6	of	of	IN
cord-001835-0s7ok4uw	2202	7	Tau	Tau	NNP
cord-001835-0s7ok4uw	2202	8	in	in	IN
cord-001835-0s7ok4uw	2202	9	the	the	DT
cord-001835-0s7ok4uw	2202	10	absence	absence	NN
cord-001835-0s7ok4uw	2202	11	of	of	IN
cord-001835-0s7ok4uw	2202	12	polyglutamic	polyglutamic	JJ
cord-001835-0s7ok4uw	2202	13	acids	acid	NNS
cord-001835-0s7ok4uw	2202	14	which	which	WDT
cord-001835-0s7ok4uw	2202	15	indicates	indicate	VBZ
cord-001835-0s7ok4uw	2202	16	that	that	IN
cord-001835-0s7ok4uw	2202	17	positive	positive	JJ
cord-001835-0s7ok4uw	2202	18	charge	charge	NN
cord-001835-0s7ok4uw	2202	19	on	on	IN
cord-001835-0s7ok4uw	2202	20	Tau	Tau	NNP
cord-001835-0s7ok4uw	2202	21	molecules	molecule	NNS
cord-001835-0s7ok4uw	2202	22	must	must	MD
cord-001835-0s7ok4uw	2202	23	be	be	VB
cord-001835-0s7ok4uw	2202	24	unconditionally	unconditionally	RB
cord-001835-0s7ok4uw	2202	25	compensated	compensate	VBN
cord-001835-0s7ok4uw	2202	26	in	in	IN
cord-001835-0s7ok4uw	2202	27	order	order	NN
cord-001835-0s7ok4uw	2202	28	to	to	TO
cord-001835-0s7ok4uw	2202	29	promote	promote	VB
cord-001835-0s7ok4uw	2202	30	amyloidogenesis	amyloidogenesis	NN
cord-001835-0s7ok4uw	2202	31	.	.	.
cord-001835-0s7ok4uw	2203	1	Thirdly	thirdly	RB
cord-001835-0s7ok4uw	2203	2	,	,	,
cord-001835-0s7ok4uw	2203	3	using	use	VBG
cord-001835-0s7ok4uw	2203	4	TEM	tem	NN
cord-001835-0s7ok4uw	2203	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2203	6	have	have	VBP
cord-001835-0s7ok4uw	2203	7	characterized	characterize	VBN
cord-001835-0s7ok4uw	2203	8	different	different	JJ
cord-001835-0s7ok4uw	2203	9	morphologies	morphology	NNS
cord-001835-0s7ok4uw	2203	10	of	of	IN
cord-001835-0s7ok4uw	2203	11	Tau	Tau	NNP
cord-001835-0s7ok4uw	2203	12	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2203	13	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2203	14	generated	generate	VBN
cord-001835-0s7ok4uw	2203	15	in	in	IN
cord-001835-0s7ok4uw	2203	16	unseeded	unseeded	JJ
cord-001835-0s7ok4uw	2203	17	and	and	CC
cord-001835-0s7ok4uw	2203	18	seeded	seeded	JJ
cord-001835-0s7ok4uw	2203	19	processes	process	NNS
cord-001835-0s7ok4uw	2203	20	.	.	.
cord-001835-0s7ok4uw	2204	1	Finally	finally	RB
cord-001835-0s7ok4uw	2204	2	,	,	,
cord-001835-0s7ok4uw	2204	3	to	to	TO
cord-001835-0s7ok4uw	2204	4	further	further	RB
cord-001835-0s7ok4uw	2204	5	characterize	characterize	VB
cord-001835-0s7ok4uw	2204	6	properties	property	NNS
cord-001835-0s7ok4uw	2204	7	of	of	IN
cord-001835-0s7ok4uw	2204	8	the	the	DT
cord-001835-0s7ok4uw	2204	9	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2204	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	2204	11	have	have	VBP
cord-001835-0s7ok4uw	2204	12	performed	perform	VBN
cord-001835-0s7ok4uw	2204	13	sedimentation	sedimentation	NN
cord-001835-0s7ok4uw	2204	14	experiments	experiment	NNS
cord-001835-0s7ok4uw	2204	15	.	.	.
cord-001835-0s7ok4uw	2205	1	Fibrils	fibril	NNS
cord-001835-0s7ok4uw	2205	2	induced	induce	VBN
cord-001835-0s7ok4uw	2205	3	by	by	IN
cord-001835-0s7ok4uw	2205	4	PLGA	PLGA	NNP
cord-001835-0s7ok4uw	2205	5	,	,	,
cord-001835-0s7ok4uw	2205	6	PDGA	PDGA	NNP
cord-001835-0s7ok4uw	2205	7	and	and	CC
cord-001835-0s7ok4uw	2205	8	heparin	heparin	NN
cord-001835-0s7ok4uw	2205	9	revealed	reveal	VBD
cord-001835-0s7ok4uw	2205	10	different	different	JJ
cord-001835-0s7ok4uw	2205	11	sedimentation	sedimentation	NN
cord-001835-0s7ok4uw	2205	12	properties	property	NNS
cord-001835-0s7ok4uw	2205	13	.	.	.
cord-001835-0s7ok4uw	2206	1	Heparin	Heparin	NNP
cord-001835-0s7ok4uw	2206	2	-	-	HYPH
cord-001835-0s7ok4uw	2206	3	induced	induce	VBN
cord-001835-0s7ok4uw	2206	4	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2206	5	underwent	undergo	VBD
cord-001835-0s7ok4uw	2206	6	sedimentation	sedimentation	NN
cord-001835-0s7ok4uw	2206	7	more	more	RBR
cord-001835-0s7ok4uw	2206	8	readily	readily	RB
cord-001835-0s7ok4uw	2206	9	than	than	IN
cord-001835-0s7ok4uw	2206	10	PDGA	PDGA	NNP
cord-001835-0s7ok4uw	2206	11	-	-	HYPH
cord-001835-0s7ok4uw	2206	12	induced	induce	VBN
cord-001835-0s7ok4uw	2206	13	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2206	14	,	,	,
cord-001835-0s7ok4uw	2206	15	whereas	whereas	IN
cord-001835-0s7ok4uw	2206	16	PLGA	PLGA	NNP
cord-001835-0s7ok4uw	2206	17	-	-	HYPH
cord-001835-0s7ok4uw	2206	18	induced	induce	VBN
cord-001835-0s7ok4uw	2206	19	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2206	20	remained	remain	VBD
cord-001835-0s7ok4uw	2206	21	in	in	IN
cord-001835-0s7ok4uw	2206	22	the	the	DT
cord-001835-0s7ok4uw	2206	23	supernatant	supernatant	NN
cord-001835-0s7ok4uw	2206	24	.	.	.
cord-001835-0s7ok4uw	2207	1	These	these	DT
cord-001835-0s7ok4uw	2207	2	results	result	NNS
cord-001835-0s7ok4uw	2207	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	2207	4	distinct	distinct	JJ
cord-001835-0s7ok4uw	2207	5	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	2207	6	properties	property	NNS
cord-001835-0s7ok4uw	2207	7	of	of	IN
cord-001835-0s7ok4uw	2207	8	these	these	DT
cord-001835-0s7ok4uw	2207	9	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2207	10	.	.	.
cord-001835-0s7ok4uw	2208	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2208	2	believe	believe	VBP
cord-001835-0s7ok4uw	2208	3	that	that	IN
cord-001835-0s7ok4uw	2208	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2208	5	findings	finding	NNS
cord-001835-0s7ok4uw	2208	6	will	will	MD
cord-001835-0s7ok4uw	2208	7	contribute	contribute	VB
cord-001835-0s7ok4uw	2208	8	to	to	IN
cord-001835-0s7ok4uw	2208	9	the	the	DT
cord-001835-0s7ok4uw	2208	10	current	current	JJ
cord-001835-0s7ok4uw	2208	11	understanding	understanding	NN
cord-001835-0s7ok4uw	2208	12	of	of	IN
cord-001835-0s7ok4uw	2208	13	the	the	DT
cord-001835-0s7ok4uw	2208	14	molecular	molecular	JJ
cord-001835-0s7ok4uw	2208	15	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2208	16	of	of	IN
cord-001835-0s7ok4uw	2208	17	Tau	Tau	NNP
cord-001835-0s7ok4uw	2208	18	amyloidogenesis	amyloidogenesis	NN
cord-001835-0s7ok4uw	2208	19	.	.	.
cord-001835-0s7ok4uw	2209	1	Self	self	NN
cord-001835-0s7ok4uw	2209	2	-	-	HYPH
cord-001835-0s7ok4uw	2209	3	organizing	organize	VBG
cord-001835-0s7ok4uw	2209	4	structures	structure	NNS
cord-001835-0s7ok4uw	2209	5	of	of	IN
cord-001835-0s7ok4uw	2209	6	alpha	alpha	NN
cord-001835-0s7ok4uw	2209	7	-	-	HYPH
cord-001835-0s7ok4uw	2209	8	synulceins	synulcein	NNS
cord-001835-0s7ok4uw	2209	9	and	and	CC
cord-001835-0s7ok4uw	2209	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2209	11	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	2209	12	by	by	IN
cord-001835-0s7ok4uw	2209	13	a	a	DT
cord-001835-0s7ok4uw	2209	14	coarse	coarse	RB
cord-001835-0s7ok4uw	2209	15	-	-	HYPH
cord-001835-0s7ok4uw	2209	16	grained	grained	JJ
cord-001835-0s7ok4uw	2209	17	Monte	Monte	NNP
cord-001835-0s7ok4uw	2209	18	Carlo	Carlo	NNP
cord-001835-0s7ok4uw	2209	19	simulation	simulation	NN
cord-001835-0s7ok4uw	2209	20	Ras	Ras	NNP
cord-001835-0s7ok4uw	2209	21	Pandey	Pandey	NNP
cord-001835-0s7ok4uw	2209	22	1	1	CD
cord-001835-0s7ok4uw	2209	23	,	,	,
cord-001835-0s7ok4uw	2209	24	Peter	Peter	NNP
cord-001835-0s7ok4uw	2209	25	Mirau	Mirau	NNP
cord-001835-0s7ok4uw	2209	26	2	2	CD
cord-001835-0s7ok4uw	2209	27	,	,	,
cord-001835-0s7ok4uw	2209	28	Barry	Barry	NNP
cord-001835-0s7ok4uw	2209	29	Farmer	Farmer	NNP
cord-001835-0s7ok4uw	2209	30	2	2	CD
cord-001835-0s7ok4uw	2209	31	1	1	CD
cord-001835-0s7ok4uw	2209	32	Alpha	Alpha	NNP
cord-001835-0s7ok4uw	2209	33	-	-	HYPH
cord-001835-0s7ok4uw	2209	34	synuclein	synuclein	NNP
cord-001835-0s7ok4uw	2209	35	(	(	-LRB-
cord-001835-0s7ok4uw	2209	36	ASN	ASN	NNP
cord-001835-0s7ok4uw	2209	37	)	)	-RRB-
cord-001835-0s7ok4uw	2209	38	consisting	consist	VBG
cord-001835-0s7ok4uw	2209	39	of	of	IN
cord-001835-0s7ok4uw	2209	40	140	140	CD
cord-001835-0s7ok4uw	2209	41	residues	residue	NNS
cord-001835-0s7ok4uw	2209	42	,	,	,
cord-001835-0s7ok4uw	2209	43	an	an	DT
cord-001835-0s7ok4uw	2209	44	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2209	45	disordered	disordered	JJ
cord-001835-0s7ok4uw	2209	46	protein	protein	NN
cord-001835-0s7ok4uw	2209	47	,	,	,
cord-001835-0s7ok4uw	2209	48	is	be	VBZ
cord-001835-0s7ok4uw	2209	49	linked	link	VBN
cord-001835-0s7ok4uw	2209	50	to	to	IN
cord-001835-0s7ok4uw	2209	51	such	such	JJ
cord-001835-0s7ok4uw	2209	52	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	2209	53	diseases	disease	NNS
cord-001835-0s7ok4uw	2209	54	as	as	IN
cord-001835-0s7ok4uw	2209	55	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	2209	56	's	's	POS
cord-001835-0s7ok4uw	2209	57	disease	disease	NN
cord-001835-0s7ok4uw	2209	58	(	(	-LRB-
cord-001835-0s7ok4uw	2209	59	PD	PD	NNP
cord-001835-0s7ok4uw	2209	60	)	)	-RRB-
cord-001835-0s7ok4uw	2209	61	and	and	CC
cord-001835-0s7ok4uw	2209	62	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	2209	63	disease	disease	NN
cord-001835-0s7ok4uw	2209	64	via	via	IN
cord-001835-0s7ok4uw	2209	65	toxic	toxic	JJ
cord-001835-0s7ok4uw	2209	66	clumping	clumping	NN
cord-001835-0s7ok4uw	2209	67	into	into	IN
cord-001835-0s7ok4uw	2209	68	ABSTRACT	abstract	JJ
cord-001835-0s7ok4uw	2209	69	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2209	70	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2209	71	.	.	.
cord-001835-0s7ok4uw	2210	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2210	2	investigate	investigate	VBP
cord-001835-0s7ok4uw	2210	3	the	the	DT
cord-001835-0s7ok4uw	2210	4	structure	structure	NN
cord-001835-0s7ok4uw	2210	5	and	and	CC
cord-001835-0s7ok4uw	2210	6	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2210	7	of	of	IN
cord-001835-0s7ok4uw	2210	8	an	an	DT
cord-001835-0s7ok4uw	2210	9	ASN	ASN	NNP
cord-001835-0s7ok4uw	2210	10	chain	chain	NN
cord-001835-0s7ok4uw	2210	11	as	as	IN
cord-001835-0s7ok4uw	2210	12	a	a	DT
cord-001835-0s7ok4uw	2210	13	function	function	NN
cord-001835-0s7ok4uw	2210	14	of	of	IN
cord-001835-0s7ok4uw	2210	15	temperature	temperature	NN
cord-001835-0s7ok4uw	2210	16	by	by	IN
cord-001835-0s7ok4uw	2210	17	a	a	DT
cord-001835-0s7ok4uw	2210	18	coarse	coarse	RB
cord-001835-0s7ok4uw	2210	19	-	-	HYPH
cord-001835-0s7ok4uw	2210	20	grained	grained	JJ
cord-001835-0s7ok4uw	2210	21	approach	approach	NN
cord-001835-0s7ok4uw	2210	22	where	where	WRB
cord-001835-0s7ok4uw	2210	23	a	a	DT
cord-001835-0s7ok4uw	2210	24	residue	residue	NN
cord-001835-0s7ok4uw	2210	25	is	be	VBZ
cord-001835-0s7ok4uw	2210	26	represented	represent	VBN
cord-001835-0s7ok4uw	2210	27	by	by	IN
cord-001835-0s7ok4uw	2210	28	a	a	DT
cord-001835-0s7ok4uw	2210	29	node	node	NN
cord-001835-0s7ok4uw	2210	30	.	.	.
cord-001835-0s7ok4uw	2211	1	In	in	IN
cord-001835-0s7ok4uw	2211	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2211	3	coarse	coarse	RB
cord-001835-0s7ok4uw	2211	4	-	-	HYPH
cord-001835-0s7ok4uw	2211	5	grained	grained	JJ
cord-001835-0s7ok4uw	2211	6	approach	approach	NN
cord-001835-0s7ok4uw	2211	7	,	,	,
cord-001835-0s7ok4uw	2211	8	a	a	DT
cord-001835-0s7ok4uw	2211	9	residue	residue	NN
cord-001835-0s7ok4uw	2211	10	is	be	VBZ
cord-001835-0s7ok4uw	2211	11	represented	represent	VBN
cord-001835-0s7ok4uw	2211	12	by	by	IN
cord-001835-0s7ok4uw	2211	13	a	a	DT
cord-001835-0s7ok4uw	2211	14	node	node	NN
cord-001835-0s7ok4uw	2211	15	.	.	.
cord-001835-0s7ok4uw	2212	1	The	the	DT
cord-001835-0s7ok4uw	2212	2	basic	basic	JJ
cord-001835-0s7ok4uw	2212	3	idea	idea	NN
cord-001835-0s7ok4uw	2212	4	is	be	VBZ
cord-001835-0s7ok4uw	2212	5	borrowed	borrow	VBN
cord-001835-0s7ok4uw	2212	6	from	from	IN
cord-001835-0s7ok4uw	2212	7	the	the	DT
cord-001835-0s7ok4uw	2212	8	'	'	``
cord-001835-0s7ok4uw	2212	9	united	united	NNP
cord-001835-0s7ok4uw	2212	10	atom	atom	NNP
cord-001835-0s7ok4uw	2212	11	'	'	''
cord-001835-0s7ok4uw	2212	12	approach	approach	NN
cord-001835-0s7ok4uw	2212	13	in	in	IN
cord-001835-0s7ok4uw	2212	14	polymer	polymer	NN
cord-001835-0s7ok4uw	2212	15	chain	chain	NN
cord-001835-0s7ok4uw	2212	16	modeling	modeling	NN
cord-001835-0s7ok4uw	2212	17	that	that	WDT
cord-001835-0s7ok4uw	2212	18	has	have	VBZ
cord-001835-0s7ok4uw	2212	19	been	be	VBN
cord-001835-0s7ok4uw	2212	20	used	use	VBN
cord-001835-0s7ok4uw	2212	21	extensively	extensively	RB
cord-001835-0s7ok4uw	2212	22	where	where	WRB
cord-001835-0s7ok4uw	2212	23	the	the	DT
cord-001835-0s7ok4uw	2212	24	benefits	benefit	NNS
cord-001835-0s7ok4uw	2212	25	and	and	CC
cord-001835-0s7ok4uw	2212	26	pitfalls	pitfall	NNS
cord-001835-0s7ok4uw	2212	27	of	of	IN
cord-001835-0s7ok4uw	2212	28	the	the	DT
cord-001835-0s7ok4uw	2212	29	method	method	NN
cord-001835-0s7ok4uw	2212	30	is	be	VBZ
cord-001835-0s7ok4uw	2212	31	explored	explore	VBN
cord-001835-0s7ok4uw	2212	32	for	for	IN
cord-001835-0s7ok4uw	2212	33	decades	decade	NNS
cord-001835-0s7ok4uw	2212	34	.	.	.
cord-001835-0s7ok4uw	2213	1	Such	such	JJ
cord-001835-0s7ok4uw	2213	2	coarse	coarse	RB
cord-001835-0s7ok4uw	2213	3	-	-	HYPH
cord-001835-0s7ok4uw	2213	4	grained	grained	JJ
cord-001835-0s7ok4uw	2213	5	method	method	NN
cord-001835-0s7ok4uw	2213	6	has	have	VBZ
cord-001835-0s7ok4uw	2213	7	also	also	RB
cord-001835-0s7ok4uw	2213	8	been	be	VBN
cord-001835-0s7ok4uw	2213	9	used	use	VBN
cord-001835-0s7ok4uw	2213	10	protein	protein	NN
cord-001835-0s7ok4uw	2213	11	chain	chain	NN
cord-001835-0s7ok4uw	2213	12	modeling	modeling	NN
cord-001835-0s7ok4uw	2213	13	in	in	IN
cord-001835-0s7ok4uw	2213	14	recent	recent	JJ
cord-001835-0s7ok4uw	2213	15	years	year	NNS
cord-001835-0s7ok4uw	2213	16	(	(	-LRB-
cord-001835-0s7ok4uw	2213	17	e.g.	e.g.	RB
cord-001835-0s7ok4uw	2213	18	AIP	AIP	NNP
cord-001835-0s7ok4uw	2213	19	Advances	advance	VBZ
cord-001835-0s7ok4uw	2213	20	5	5	CD
cord-001835-0s7ok4uw	2213	21	,	,	,
cord-001835-0s7ok4uw	2213	22	092502	092502	CD
cord-001835-0s7ok4uw	2213	23	(	(	-LRB-
cord-001835-0s7ok4uw	2213	24	2015	2015	CD
cord-001835-0s7ok4uw	2213	25	)	)	-RRB-
cord-001835-0s7ok4uw	2213	26	)	)	-RRB-
cord-001835-0s7ok4uw	2213	27	.	.	.
cord-001835-0s7ok4uw	2214	1	Although	although	IN
cord-001835-0s7ok4uw	2214	2	the	the	DT
cord-001835-0s7ok4uw	2214	3	atomic	atomic	JJ
cord-001835-0s7ok4uw	2214	4	scale	scale	NN
cord-001835-0s7ok4uw	2214	5	structural	structural	JJ
cord-001835-0s7ok4uw	2214	6	resolution	resolution	NN
cord-001835-0s7ok4uw	2214	7	is	be	VBZ
cord-001835-0s7ok4uw	2214	8	sacrificed	sacrifice	VBN
cord-001835-0s7ok4uw	2214	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2214	10	specificity	specificity	NN
cord-001835-0s7ok4uw	2214	11	is	be	VBZ
cord-001835-0s7ok4uw	2214	12	captured	capture	VBN
cord-001835-0s7ok4uw	2214	13	via	via	IN
cord-001835-0s7ok4uw	2214	14	a	a	DT
cord-001835-0s7ok4uw	2214	15	set	set	NN
cord-001835-0s7ok4uw	2214	16	of	of	IN
cord-001835-0s7ok4uw	2214	17	unique	unique	JJ
cord-001835-0s7ok4uw	2214	18	knowledge	knowledge	NN
cord-001835-0s7ok4uw	2214	19	-	-	HYPH
cord-001835-0s7ok4uw	2214	20	based	base	VBN
cord-001835-0s7ok4uw	2214	21	residue	residue	NN
cord-001835-0s7ok4uw	2214	22	-	-	HYPH
cord-001835-0s7ok4uw	2214	23	residue	residue	NN
cord-001835-0s7ok4uw	2214	24	interactions	interaction	NNS
cord-001835-0s7ok4uw	2214	25	matrix	matrix	NN
cord-001835-0s7ok4uw	2214	26	(	(	-LRB-
cord-001835-0s7ok4uw	2214	27	e.g.	e.g.	IN
cord-001835-0s7ok4uw	2214	28	classic	classic	JJ
cord-001835-0s7ok4uw	2214	29	Miyazawa	Miyazawa	NNP
cord-001835-0s7ok4uw	2214	30	-	-	HYPH
cord-001835-0s7ok4uw	2214	31	Jernigan	Jernigan	NNP
cord-001835-0s7ok4uw	2214	32	matrix	matrix	NN
cord-001835-0s7ok4uw	2214	33	,	,	,
cord-001835-0s7ok4uw	2214	34	Macromolecules	Macromolecules	NNP
cord-001835-0s7ok4uw	2214	35	18	18	CD
cord-001835-0s7ok4uw	2214	36	,	,	,
cord-001835-0s7ok4uw	2214	37	534	534	CD
cord-001835-0s7ok4uw	2214	38	(	(	-LRB-
cord-001835-0s7ok4uw	2214	39	1985	1985	CD
cord-001835-0s7ok4uw	2214	40	)	)	-RRB-
cord-001835-0s7ok4uw	2214	41	)	)	-RRB-
cord-001835-0s7ok4uw	2214	42	.	.	.
cord-001835-0s7ok4uw	2215	1	A	a	DT
cord-001835-0s7ok4uw	2215	2	number	number	NN
cord-001835-0s7ok4uw	2215	3	of	of	IN
cord-001835-0s7ok4uw	2215	4	local	local	JJ
cord-001835-0s7ok4uw	2215	5	and	and	CC
cord-001835-0s7ok4uw	2215	6	global	global	JJ
cord-001835-0s7ok4uw	2215	7	physical	physical	JJ
cord-001835-0s7ok4uw	2215	8	quantities	quantity	NNS
cord-001835-0s7ok4uw	2215	9	are	be	VBP
cord-001835-0s7ok4uw	2215	10	analyzed	analyze	VBN
cord-001835-0s7ok4uw	2215	11	such	such	JJ
cord-001835-0s7ok4uw	2215	12	as	as	IN
cord-001835-0s7ok4uw	2215	13	contact	contact	NN
cord-001835-0s7ok4uw	2215	14	map	map	NN
cord-001835-0s7ok4uw	2215	15	,	,	,
cord-001835-0s7ok4uw	2215	16	neighborhood	neighborhood	NN
cord-001835-0s7ok4uw	2215	17	and	and	CC
cord-001835-0s7ok4uw	2215	18	mobility	mobility	NN
cord-001835-0s7ok4uw	2215	19	profiles	profile	NNS
cord-001835-0s7ok4uw	2215	20	,	,	,
cord-001835-0s7ok4uw	2215	21	mean	mean	VBP
cord-001835-0s7ok4uw	2215	22	square	square	JJ
cord-001835-0s7ok4uw	2215	23	displacement	displacement	NN
cord-001835-0s7ok4uw	2215	24	of	of	IN
cord-001835-0s7ok4uw	2215	25	protein	protein	NN
cord-001835-0s7ok4uw	2215	26	,	,	,
cord-001835-0s7ok4uw	2215	27	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2215	28	radius	radius	NN
cord-001835-0s7ok4uw	2215	29	of	of	IN
cord-001835-0s7ok4uw	2215	30	gyration	gyration	NN
cord-001835-0s7ok4uw	2215	31	and	and	CC
cord-001835-0s7ok4uw	2215	32	the	the	DT
cord-001835-0s7ok4uw	2215	33	structure	structure	NN
cord-001835-0s7ok4uw	2215	34	factor	factor	NN
cord-001835-0s7ok4uw	2215	35	.	.	.
cord-001835-0s7ok4uw	2216	1	Based	base	VBN
cord-001835-0s7ok4uw	2216	2	on	on	IN
cord-001835-0s7ok4uw	2216	3	the	the	DT
cord-001835-0s7ok4uw	2216	4	mobility	mobility	NN
cord-001835-0s7ok4uw	2216	5	profile	profile	NN
cord-001835-0s7ok4uw	2216	6	,	,	,
cord-001835-0s7ok4uw	2216	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	2216	8	are	be	VBP
cord-001835-0s7ok4uw	2216	9	able	able	JJ
cord-001835-0s7ok4uw	2216	10	to	to	TO
cord-001835-0s7ok4uw	2216	11	identify	identify	VB
cord-001835-0s7ok4uw	2216	12	three	three	CD
cord-001835-0s7ok4uw	2216	13	distinct	distinct	JJ
cord-001835-0s7ok4uw	2216	14	segment	segment	NN
cord-001835-0s7ok4uw	2216	15	of	of	IN
cord-001835-0s7ok4uw	2216	16	ASN	ASN	NNP
cord-001835-0s7ok4uw	2216	17	along	along	IN
cord-001835-0s7ok4uw	2216	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2216	19	contour	contour	NN
cord-001835-0s7ok4uw	2216	20	,	,	,
cord-001835-0s7ok4uw	2216	21	i.e.	i.e.	FW
cord-001835-0s7ok4uw	2216	22	sluggish	sluggish	JJ
cord-001835-0s7ok4uw	2216	23	Nterminal	Nterminal	NNP
cord-001835-0s7ok4uw	2216	24	(	(	-LRB-
cord-001835-0s7ok4uw	2216	25	1	1	CD
cord-001835-0s7ok4uw	2216	26	-	-	SYM
cord-001835-0s7ok4uw	2216	27	60	60	CD
cord-001835-0s7ok4uw	2216	28	)	)	-RRB-
cord-001835-0s7ok4uw	2216	29	and	and	CC
cord-001835-0s7ok4uw	2216	30	C	c	NN
cord-001835-0s7ok4uw	2216	31	-	-	HYPH
cord-001835-0s7ok4uw	2216	32	terminal	terminal	NN
cord-001835-0s7ok4uw	2216	33	(	(	-LRB-
cord-001835-0s7ok4uw	2216	34	96	96	CD
cord-001835-0s7ok4uw	2216	35	-	-	SYM
cord-001835-0s7ok4uw	2216	36	140	140	CD
cord-001835-0s7ok4uw	2216	37	,	,	,
cord-001835-0s7ok4uw	2216	38	least	least	JJS
cord-001835-0s7ok4uw	2216	39	mobile	mobile	JJ
cord-001835-0s7ok4uw	2216	40	)	)	-RRB-
cord-001835-0s7ok4uw	2216	41	separated	separate	VBN
cord-001835-0s7ok4uw	2216	42	by	by	IN
cord-001835-0s7ok4uw	2216	43	the	the	DT
cord-001835-0s7ok4uw	2216	44	central	central	JJ
cord-001835-0s7ok4uw	2216	45	region	region	NN
cord-001835-0s7ok4uw	2216	46	(	(	-LRB-
cord-001835-0s7ok4uw	2216	47	61	61	CD
cord-001835-0s7ok4uw	2216	48	-	-	SYM
cord-001835-0s7ok4uw	2216	49	95	95	CD
cord-001835-0s7ok4uw	2216	50	)	)	-RRB-
cord-001835-0s7ok4uw	2216	51	,	,	,
cord-001835-0s7ok4uw	2216	52	the	the	DT
cord-001835-0s7ok4uw	2216	53	nonamyloid	nonamyloid	NNP
cord-001835-0s7ok4uw	2216	54	component	component	NN
cord-001835-0s7ok4uw	2216	55	(	(	-LRB-
cord-001835-0s7ok4uw	2216	56	NAC	NAC	NNP
cord-001835-0s7ok4uw	2216	57	)	)	-RRB-
cord-001835-0s7ok4uw	2216	58	with	with	IN
cord-001835-0s7ok4uw	2216	59	higher	high	JJR
cord-001835-0s7ok4uw	2216	60	mobility	mobility	NN
cord-001835-0s7ok4uw	2216	61	.	.	.
cord-001835-0s7ok4uw	2217	1	Contact	contact	NN
cord-001835-0s7ok4uw	2217	2	profile	profile	NN
cord-001835-0s7ok4uw	2217	3	shows	show	VBZ
cord-001835-0s7ok4uw	2217	4	that	that	IN
cord-001835-0s7ok4uw	2217	5	the	the	DT
cord-001835-0s7ok4uw	2217	6	probability	probability	NN
cord-001835-0s7ok4uw	2217	7	of	of	IN
cord-001835-0s7ok4uw	2217	8	intrachain	intrachain	NN
cord-001835-0s7ok4uw	2217	9	residue	residue	NN
cord-001835-0s7ok4uw	2217	10	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2217	11	(	(	-LRB-
cord-001835-0s7ok4uw	2217	12	clumping	clumping	NN
cord-001835-0s7ok4uw	2217	13	)	)	-RRB-
cord-001835-0s7ok4uw	2217	14	is	be	VBZ
cord-001835-0s7ok4uw	2217	15	higher	high	JJR
cord-001835-0s7ok4uw	2217	16	in	in	IN
cord-001835-0s7ok4uw	2217	17	the	the	DT
cord-001835-0s7ok4uw	2217	18	N	n	CD
cord-001835-0s7ok4uw	2217	19	-	-	HYPH
cord-001835-0s7ok4uw	2217	20	terminal	terminal	NN
cord-001835-0s7ok4uw	2217	21	region	region	NN
cord-001835-0s7ok4uw	2217	22	than	than	IN
cord-001835-0s7ok4uw	2217	23	the	the	DT
cord-001835-0s7ok4uw	2217	24	C	c	NN
cord-001835-0s7ok4uw	2217	25	-	-	HYPH
cord-001835-0s7ok4uw	2217	26	terminal	terminal	NN
cord-001835-0s7ok4uw	2217	27	with	with	IN
cord-001835-0s7ok4uw	2217	28	least	least	JJS
cord-001835-0s7ok4uw	2217	29	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2217	30	in	in	IN
cord-001835-0s7ok4uw	2217	31	the	the	DT
cord-001835-0s7ok4uw	2217	32	NAC	NAC	NNP
cord-001835-0s7ok4uw	2217	33	region	region	NN
cord-001835-0s7ok4uw	2217	34	.	.	.
cord-001835-0s7ok4uw	2218	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2218	2	find	find	VBP
cord-001835-0s7ok4uw	2218	3	that	that	IN
cord-001835-0s7ok4uw	2218	4	the	the	DT
cord-001835-0s7ok4uw	2218	5	radius	radius	NN
cord-001835-0s7ok4uw	2218	6	of	of	IN
cord-001835-0s7ok4uw	2218	7	gyration	gyration	NN
cord-001835-0s7ok4uw	2218	8	(	(	-LRB-
cord-001835-0s7ok4uw	2218	9	Rg	Rg	NNP
cord-001835-0s7ok4uw	2218	10	)	)	-RRB-
cord-001835-0s7ok4uw	2218	11	decays	decay	VBZ
cord-001835-0s7ok4uw	2218	12	monotonically	monotonically	RB
cord-001835-0s7ok4uw	2218	13	with	with	IN
cord-001835-0s7ok4uw	2218	14	the	the	DT
cord-001835-0s7ok4uw	2218	15	temperature	temperature	NN
cord-001835-0s7ok4uw	2218	16	,	,	,
cord-001835-0s7ok4uw	2218	17	consistent	consistent	JJ
cord-001835-0s7ok4uw	2218	18	with	with	IN
cord-001835-0s7ok4uw	2218	19	the	the	DT
cord-001835-0s7ok4uw	2218	20	finding	finding	NN
cord-001835-0s7ok4uw	2218	21	of	of	IN
cord-001835-0s7ok4uw	2218	22	Allison	Allison	NNP
cord-001835-0s7ok4uw	2218	23	et	et	NNP
cord-001835-0s7ok4uw	2218	24	al	al	NNP
cord-001835-0s7ok4uw	2218	25	.	.	.
cord-001835-0s7ok4uw	2219	1	(	(	-LRB-
cord-001835-0s7ok4uw	2219	2	JACS	JACS	NNP
cord-001835-0s7ok4uw	2219	3	,	,	,
cord-001835-0s7ok4uw	2219	4	131	131	CD
cord-001835-0s7ok4uw	2219	5	,	,	,
cord-001835-0s7ok4uw	2219	6	18314	18314	CD
cord-001835-0s7ok4uw	2219	7	(	(	-LRB-
cord-001835-0s7ok4uw	2219	8	2009	2009	CD
cord-001835-0s7ok4uw	2219	9	)	)	-RRB-
cord-001835-0s7ok4uw	2219	10	)	)	-RRB-
cord-001835-0s7ok4uw	2219	11	.	.	.
cord-001835-0s7ok4uw	2220	1	From	from	IN
cord-001835-0s7ok4uw	2220	2	the	the	DT
cord-001835-0s7ok4uw	2220	3	detail	detail	NN
cord-001835-0s7ok4uw	2220	4	analysis	analysis	NN
cord-001835-0s7ok4uw	2220	5	of	of	IN
cord-001835-0s7ok4uw	2220	6	the	the	DT
cord-001835-0s7ok4uw	2220	7	structure	structure	NN
cord-001835-0s7ok4uw	2220	8	factor	factor	NN
cord-001835-0s7ok4uw	2220	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	2220	10	are	be	VBP
cord-001835-0s7ok4uw	2220	11	able	able	JJ
cord-001835-0s7ok4uw	2220	12	to	to	TO
cord-001835-0s7ok4uw	2220	13	predict	predict	VB
cord-001835-0s7ok4uw	2220	14	the	the	DT
cord-001835-0s7ok4uw	2220	15	variation	variation	NN
cord-001835-0s7ok4uw	2220	16	of	of	IN
cord-001835-0s7ok4uw	2220	17	the	the	DT
cord-001835-0s7ok4uw	2220	18	spatial	spatial	JJ
cord-001835-0s7ok4uw	2220	19	mass	mass	NN
cord-001835-0s7ok4uw	2220	20	distribution	distribution	NN
cord-001835-0s7ok4uw	2220	21	with	with	IN
cord-001835-0s7ok4uw	2220	22	the	the	DT
cord-001835-0s7ok4uw	2220	23	temperature	temperature	NN
cord-001835-0s7ok4uw	2220	24	as	as	IN
cord-001835-0s7ok4uw	2220	25	the	the	DT
cord-001835-0s7ok4uw	2220	26	residues	residue	NNS
cord-001835-0s7ok4uw	2220	27	in	in	IN
cord-001835-0s7ok4uw	2220	28	ASN	asn	NN
cord-001835-0s7ok4uw	2220	29	chain	chain	NN
cord-001835-0s7ok4uw	2220	30	organize	organize	VB
cord-001835-0s7ok4uw	2220	31	and	and	CC
cord-001835-0s7ok4uw	2220	32	disperse	disperse	VB
cord-001835-0s7ok4uw	2220	33	by	by	IN
cord-001835-0s7ok4uw	2220	34	evaluating	evaluate	VBG
cord-001835-0s7ok4uw	2220	35	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2220	36	effective	effective	JJ
cord-001835-0s7ok4uw	2220	37	dimension	dimension	NN
cord-001835-0s7ok4uw	2221	1	D.	D.	NNP
cord-001835-0s7ok4uw	2222	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2222	2	find	find	VBP
cord-001835-0s7ok4uw	2222	3	the	the	DT
cord-001835-0s7ok4uw	2222	4	protein	protein	NN
cord-001835-0s7ok4uw	2222	5	conforms	conform	VBZ
cord-001835-0s7ok4uw	2222	6	to	to	IN
cord-001835-0s7ok4uw	2222	7	a	a	DT
cord-001835-0s7ok4uw	2222	8	globular	globular	JJ
cord-001835-0s7ok4uw	2222	9	structure	structure	NN
cord-001835-0s7ok4uw	2222	10	(	(	-LRB-
cord-001835-0s7ok4uw	2222	11	D3	D3	NNP
cord-001835-0s7ok4uw	2222	12	)	)	-RRB-
cord-001835-0s7ok4uw	2222	13	at	at	IN
cord-001835-0s7ok4uw	2222	14	the	the	DT
cord-001835-0s7ok4uw	2222	15	low	low	JJ
cord-001835-0s7ok4uw	2222	16	temperatures	temperature	NNS
cord-001835-0s7ok4uw	2222	17	and	and	CC
cord-001835-0s7ok4uw	2222	18	to	to	IN
cord-001835-0s7ok4uw	2222	19	a	a	DT
cord-001835-0s7ok4uw	2222	20	random	random	JJ
cord-001835-0s7ok4uw	2222	21	coil	coil	NN
cord-001835-0s7ok4uw	2222	22	(	(	-LRB-
cord-001835-0s7ok4uw	2222	23	D2	d2	NN
cord-001835-0s7ok4uw	2222	24	)	)	-RRB-
cord-001835-0s7ok4uw	2222	25	at	at	IN
cord-001835-0s7ok4uw	2222	26	high	high	JJ
cord-001835-0s7ok4uw	2222	27	temperatures	temperature	NNS
cord-001835-0s7ok4uw	2222	28	which	which	WDT
cord-001835-0s7ok4uw	2222	29	is	be	VBZ
cord-001835-0s7ok4uw	2222	30	consistent	consistent	JJ
cord-001835-0s7ok4uw	2222	31	with	with	IN
cord-001835-0s7ok4uw	2222	32	the	the	DT
cord-001835-0s7ok4uw	2222	33	estimates	estimate	NNS
cord-001835-0s7ok4uw	2222	34	of	of	IN
cord-001835-0s7ok4uw	2222	35	Uversky	Uversky	NNP
cord-001835-0s7ok4uw	2222	36	et	et	NNP
cord-001835-0s7ok4uw	2222	37	al	al	NNP
cord-001835-0s7ok4uw	2222	38	.	.	.
cord-001835-0s7ok4uw	2223	1	(	(	-LRB-
cord-001835-0s7ok4uw	2223	2	J.	J.	NNP
cord-001835-0s7ok4uw	2223	3	Biol	Biol	NNP
cord-001835-0s7ok4uw	2223	4	.	.	.
cord-001835-0s7ok4uw	2224	1	Chem	Chem	NNP
cord-001835-0s7ok4uw	2224	2	.	.	.
cord-001835-0s7ok4uw	2225	1	277	277	CD
cord-001835-0s7ok4uw	2225	2	,	,	,
cord-001835-0s7ok4uw	2225	3	11970	11970	CD
cord-001835-0s7ok4uw	2225	4	(	(	-LRB-
cord-001835-0s7ok4uw	2225	5	2002	2002	CD
cord-001835-0s7ok4uw	2225	6	)	)	-RRB-
cord-001835-0s7ok4uw	2225	7	)	)	-RRB-
cord-001835-0s7ok4uw	2225	8	.	.	.
cord-001835-0s7ok4uw	2226	1	In	in	IN
cord-001835-0s7ok4uw	2226	2	addition	addition	NN
cord-001835-0s7ok4uw	2226	3	,	,	,
cord-001835-0s7ok4uw	2226	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	2226	5	provide	provide	VBP
cord-001835-0s7ok4uw	2226	6	the	the	DT
cord-001835-0s7ok4uw	2226	7	estimates	estimate	NNS
cord-001835-0s7ok4uw	2226	8	of	of	IN
cord-001835-0s7ok4uw	2226	9	D	D	NNP
cord-001835-0s7ok4uw	2226	10	(	(	-LRB-
cord-001835-0s7ok4uw	2226	11	3	3	CD
cord-001835-0s7ok4uw	2226	12	D	d	NN
cord-001835-0s7ok4uw	2226	13	2	2	CD
cord-001835-0s7ok4uw	2226	14	)	)	-RRB-
cord-001835-0s7ok4uw	2226	15	for	for	IN
cord-001835-0s7ok4uw	2226	16	the	the	DT
cord-001835-0s7ok4uw	2226	17	intermediate	intermediate	JJ
cord-001835-0s7ok4uw	2226	18	structures	structure	NNS
cord-001835-0s7ok4uw	2226	19	as	as	IN
cord-001835-0s7ok4uw	2226	20	the	the	DT
cord-001835-0s7ok4uw	2226	21	protein	protein	NN
cord-001835-0s7ok4uw	2226	22	chain	chain	NN
cord-001835-0s7ok4uw	2226	23	makes	make	VBZ
cord-001835-0s7ok4uw	2226	24	a	a	DT
cord-001835-0s7ok4uw	2226	25	transition	transition	NN
cord-001835-0s7ok4uw	2226	26	from	from	IN
cord-001835-0s7ok4uw	2226	27	globular	globular	JJ
cord-001835-0s7ok4uw	2226	28	to	to	IN
cord-001835-0s7ok4uw	2226	29	random	random	JJ
cord-001835-0s7ok4uw	2226	30	coil	coil	NN
cord-001835-0s7ok4uw	2226	31	.	.	.
cord-001835-0s7ok4uw	2227	1	Questions	question	NNS
cord-001835-0s7ok4uw	2227	2	under	under	IN
cord-001835-0s7ok4uw	2227	3	-	-	HYPH
cord-001835-0s7ok4uw	2227	4	investigation	investigation	NN
cord-001835-0s7ok4uw	2227	5	includes	include	VBZ
cord-001835-0s7ok4uw	2227	6	what	what	WP
cord-001835-0s7ok4uw	2227	7	are	be	VBP
cord-001835-0s7ok4uw	2227	8	the	the	DT
cord-001835-0s7ok4uw	2227	9	effects	effect	NNS
cord-001835-0s7ok4uw	2227	10	of	of	IN
cord-001835-0s7ok4uw	2227	11	mutations	mutation	NNS
cord-001835-0s7ok4uw	2227	12	(	(	-LRB-
cord-001835-0s7ok4uw	2227	13	e.g.	e.g.	RB
cord-001835-0s7ok4uw	2227	14	b	b	NN
cord-001835-0s7ok4uw	2227	15	-	-	:
cord-001835-0s7ok4uw	2227	16	and	and	CC
cord-001835-0s7ok4uw	2227	17	g	g	NNP
cord-001835-0s7ok4uw	2227	18	-	-	HYPH
cord-001835-0s7ok4uw	2227	19	synuclein	synuclein	NNP
cord-001835-0s7ok4uw	2227	20	)	)	-RRB-
cord-001835-0s7ok4uw	2227	21	,	,	,
cord-001835-0s7ok4uw	2227	22	how	how	WRB
cord-001835-0s7ok4uw	2227	23	does	do	VBZ
cord-001835-0s7ok4uw	2227	24	the	the	DT
cord-001835-0s7ok4uw	2227	25	structure	structure	NN
cord-001835-0s7ok4uw	2227	26	of	of	IN
cord-001835-0s7ok4uw	2227	27	an	an	DT
cord-001835-0s7ok4uw	2227	28	isolated	isolated	JJ
cord-001835-0s7ok4uw	2227	29	ASN	asn	NN
cord-001835-0s7ok4uw	2227	30	chain	chain	NN
cord-001835-0s7ok4uw	2227	31	change	change	NN
cord-001835-0s7ok4uw	2227	32	in	in	IN
cord-001835-0s7ok4uw	2227	33	presence	presence	NN
cord-001835-0s7ok4uw	2227	34	of	of	IN
cord-001835-0s7ok4uw	2227	35	many	many	JJ
cord-001835-0s7ok4uw	2227	36	interacting	interact	VBG
cord-001835-0s7ok4uw	2227	37	protein	protein	NN
cord-001835-0s7ok4uw	2227	38	chains	chain	NNS
cord-001835-0s7ok4uw	2227	39	,	,	,
cord-001835-0s7ok4uw	2227	40	and	and	CC
cord-001835-0s7ok4uw	2227	41	how	how	WRB
cord-001835-0s7ok4uw	2227	42	do	do	VBP
cord-001835-0s7ok4uw	2227	43	they	-PRON-	PRP
cord-001835-0s7ok4uw	2227	44	organize	organize	VB
cord-001835-0s7ok4uw	2227	45	over	over	IN
cord-001835-0s7ok4uw	2227	46	the	the	DT
cord-001835-0s7ok4uw	2227	47	multiple	multiple	JJ
cord-001835-0s7ok4uw	2227	48	length	length	NN
cord-001835-0s7ok4uw	2227	49	scales	scale	NNS
cord-001835-0s7ok4uw	2227	50	?	?	.
cord-001835-0s7ok4uw	2228	1	Attempts	attempt	NNS
cord-001835-0s7ok4uw	2228	2	will	will	MD
cord-001835-0s7ok4uw	2228	3	be	be	VB
cord-001835-0s7ok4uw	2228	4	made	make	VBN
cord-001835-0s7ok4uw	2228	5	to	to	TO
cord-001835-0s7ok4uw	2228	6	address	address	VB
cord-001835-0s7ok4uw	2228	7	some	some	DT
cord-001835-0s7ok4uw	2228	8	of	of	IN
cord-001835-0s7ok4uw	2228	9	these	these	DT
cord-001835-0s7ok4uw	2228	10	issues	issue	NNS
cord-001835-0s7ok4uw	2228	11	as	as	IN
cord-001835-0s7ok4uw	2228	12	the	the	DT
cord-001835-0s7ok4uw	2228	13	data	datum	NNS
cord-001835-0s7ok4uw	2228	14	become	become	VBP
cord-001835-0s7ok4uw	2228	15	available	available	JJ
cord-001835-0s7ok4uw	2228	16	.	.	.
cord-001835-0s7ok4uw	2229	1	Tear	tear	VB
cord-001835-0s7ok4uw	2229	2	down	down	RP
cord-001835-0s7ok4uw	2229	3	the	the	DT
cord-001835-0s7ok4uw	2229	4	wall	wall	NN
cord-001835-0s7ok4uw	2229	5	:	:	:
cord-001835-0s7ok4uw	2229	6	dismantling	dismantle	VBG
cord-001835-0s7ok4uw	2229	7	the	the	DT
cord-001835-0s7ok4uw	2229	8	biofilm	biofilm	NN
cord-001835-0s7ok4uw	2229	9	scaffold	scaffold	NN
cord-001835-0s7ok4uw	2229	10	of	of	IN
cord-001835-0s7ok4uw	2229	11	E.coli	E.coli	NNS
cord-001835-0s7ok4uw	2229	12	Cesyen	Cesyen	NNP
cord-001835-0s7ok4uw	2229	13	Cedeno	Cedeno	NNP
cord-001835-0s7ok4uw	2229	14	1	1	CD
cord-001835-0s7ok4uw	2229	15	,	,	,
cord-001835-0s7ok4uw	2229	16	Nani	Nani	NNP
cord-001835-0s7ok4uw	2229	17	Van	Van	NNP
cord-001835-0s7ok4uw	2229	18	Gerven	Gerven	NNP
cord-001835-0s7ok4uw	2229	19	1	1	CD
cord-001835-0s7ok4uw	2229	20	,	,	,
cord-001835-0s7ok4uw	2229	21	Wim	Wim	NNP
cord-001835-0s7ok4uw	2229	22	Jonckheere	Jonckheere	NNP
cord-001835-0s7ok4uw	2229	23	1	1	CD
cord-001835-0s7ok4uw	2229	24	,	,	,
cord-001835-0s7ok4uw	2229	25	Imke	Imke	NNP
cord-001835-0s7ok4uw	2229	26	Van	Van	NNP
cord-001835-0s7ok4uw	2229	27	den	den	NNP
cord-001835-0s7ok4uw	2229	28	Broek	Broek	NNP
cord-001835-0s7ok4uw	2229	29	1	1	CD
cord-001835-0s7ok4uw	2229	30	,	,	,
cord-001835-0s7ok4uw	2229	31	Han	Han	NNP
cord-001835-0s7ok4uw	2229	32	Remaut	Remaut	NNP
cord-001835-0s7ok4uw	2229	33	1	1	CD
cord-001835-0s7ok4uw	2229	34	,	,	,
cord-001835-0s7ok4uw	2229	35	Peter	Peter	NNP
cord-001835-0s7ok4uw	2229	36	Tompa	Tompa	NNP
cord-001835-0s7ok4uw	2229	37	1	1	CD
cord-001835-0s7ok4uw	2229	38	1	1	CD
cord-001835-0s7ok4uw	2229	39	CsgA	CsgA	NNP
cord-001835-0s7ok4uw	2229	40	is	be	VBZ
cord-001835-0s7ok4uw	2229	41	the	the	DT
cord-001835-0s7ok4uw	2229	42	major	major	JJ
cord-001835-0s7ok4uw	2229	43	subunit	subunit	NN
cord-001835-0s7ok4uw	2229	44	of	of	IN
cord-001835-0s7ok4uw	2229	45	the	the	DT
cord-001835-0s7ok4uw	2229	46	so	so	RB
cord-001835-0s7ok4uw	2229	47	-	-	HYPH
cord-001835-0s7ok4uw	2229	48	called	call	VBN
cord-001835-0s7ok4uw	2229	49	curli	curli	NN
cord-001835-0s7ok4uw	2229	50	fiber	fiber	NN
cord-001835-0s7ok4uw	2229	51	system	system	NN
cord-001835-0s7ok4uw	2229	52	.	.	.
cord-001835-0s7ok4uw	2230	1	This	this	DT
cord-001835-0s7ok4uw	2230	2	is	be	VBZ
cord-001835-0s7ok4uw	2230	3	an	an	DT
cord-001835-0s7ok4uw	2230	4	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2230	5	structure	structure	NN
cord-001835-0s7ok4uw	2230	6	formed	form	VBN
cord-001835-0s7ok4uw	2230	7	in	in	IN
cord-001835-0s7ok4uw	2230	8	the	the	DT
cord-001835-0s7ok4uw	2230	9	outer	outer	JJ
cord-001835-0s7ok4uw	2230	10	membrane	membrane	NN
cord-001835-0s7ok4uw	2230	11	on	on	IN
cord-001835-0s7ok4uw	2230	12	E.coli	E.coli	NNS
cord-001835-0s7ok4uw	2230	13	and	and	CC
cord-001835-0s7ok4uw	2230	14	acts	act	VBZ
cord-001835-0s7ok4uw	2230	15	as	as	IN
cord-001835-0s7ok4uw	2230	16	a	a	DT
cord-001835-0s7ok4uw	2230	17	scaffold	scaffold	NN
cord-001835-0s7ok4uw	2230	18	for	for	IN
cord-001835-0s7ok4uw	2230	19	the	the	DT
cord-001835-0s7ok4uw	2230	20	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	2230	21	machinery	machinery	NN
cord-001835-0s7ok4uw	2230	22	/	/	SYM
cord-001835-0s7ok4uw	2230	23	matrix	matrix	NN
cord-001835-0s7ok4uw	2230	24	in	in	IN
cord-001835-0s7ok4uw	2230	25	the	the	DT
cord-001835-0s7ok4uw	2230	26	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	2230	27	milieu	milieu	NN
cord-001835-0s7ok4uw	2230	28	(	(	-LRB-
cord-001835-0s7ok4uw	2230	29	biofilms	biofilm	NNS
cord-001835-0s7ok4uw	2230	30	)	)	-RRB-
cord-001835-0s7ok4uw	2230	31	.	.	.
cord-001835-0s7ok4uw	2231	1	Extracellular	Extracellular	NNP
cord-001835-0s7ok4uw	2231	2	matrices	matrix	NNS
cord-001835-0s7ok4uw	2231	3	of	of	IN
cord-001835-0s7ok4uw	2231	4	this	this	DT
cord-001835-0s7ok4uw	2231	5	nature	nature	NN
cord-001835-0s7ok4uw	2231	6	are	be	VBP
cord-001835-0s7ok4uw	2231	7	robust	robust	JJ
cord-001835-0s7ok4uw	2231	8	platforms	platform	NNS
cord-001835-0s7ok4uw	2231	9	helping	help	VBG
cord-001835-0s7ok4uw	2231	10	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	2231	11	colonization	colonization	NN
cord-001835-0s7ok4uw	2231	12	;	;	:
cord-001835-0s7ok4uw	2231	13	in	in	IN
cord-001835-0s7ok4uw	2231	14	this	this	DT
cord-001835-0s7ok4uw	2231	15	context	context	NN
cord-001835-0s7ok4uw	2231	16	CsgA	CsgA	NNP
cord-001835-0s7ok4uw	2231	17	becomes	become	VBZ
cord-001835-0s7ok4uw	2231	18	a	a	DT
cord-001835-0s7ok4uw	2231	19	key	key	JJ
cord-001835-0s7ok4uw	2231	20	target	target	NN
cord-001835-0s7ok4uw	2231	21	in	in	IN
cord-001835-0s7ok4uw	2231	22	order	order	NN
cord-001835-0s7ok4uw	2231	23	to	to	TO
cord-001835-0s7ok4uw	2231	24	break	break	VB
cord-001835-0s7ok4uw	2231	25	the	the	DT
cord-001835-0s7ok4uw	2231	26	architecture	architecture	NN
cord-001835-0s7ok4uw	2231	27	within	within	IN
cord-001835-0s7ok4uw	2231	28	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	2231	29	biofilms	biofilm	NNS
cord-001835-0s7ok4uw	2231	30	.	.	.
cord-001835-0s7ok4uw	2232	1	Chaperones	chaperone	NNS
cord-001835-0s7ok4uw	2232	2	are	be	VBP
cord-001835-0s7ok4uw	2232	3	molecular	molecular	JJ
cord-001835-0s7ok4uw	2232	4	machines	machine	NNS
cord-001835-0s7ok4uw	2232	5	able	able	JJ
cord-001835-0s7ok4uw	2232	6	to	to	TO
cord-001835-0s7ok4uw	2232	7	stabilize	stabilize	VB
cord-001835-0s7ok4uw	2232	8	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	2232	9	prone	prone	JJ
cord-001835-0s7ok4uw	2232	10	proteins	protein	NNS
cord-001835-0s7ok4uw	2232	11	or	or	CC
cord-001835-0s7ok4uw	2232	12	even	even	RB
cord-001835-0s7ok4uw	2232	13	retrieve	retrieve	VB
cord-001835-0s7ok4uw	2232	14	proteins	protein	NNS
cord-001835-0s7ok4uw	2232	15	trapped	trap	VBN
cord-001835-0s7ok4uw	2232	16	in	in	IN
cord-001835-0s7ok4uw	2232	17	non	non	JJ
cord-001835-0s7ok4uw	2232	18	-	-	JJ
cord-001835-0s7ok4uw	2232	19	physiological	physiological	JJ
cord-001835-0s7ok4uw	2232	20	states	state	NNS
cord-001835-0s7ok4uw	2232	21	.	.	.
cord-001835-0s7ok4uw	2233	1	Here	here	RB
cord-001835-0s7ok4uw	2233	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2233	3	show	show	VBP
cord-001835-0s7ok4uw	2233	4	how	how	WRB
cord-001835-0s7ok4uw	2233	5	ERD14	erd14	DT
cord-001835-0s7ok4uw	2233	6	acts	act	VBZ
cord-001835-0s7ok4uw	2233	7	as	as	IN
cord-001835-0s7ok4uw	2233	8	a	a	DT
cord-001835-0s7ok4uw	2233	9	molecular	molecular	JJ
cord-001835-0s7ok4uw	2233	10	chaperone	chaperone	NN
cord-001835-0s7ok4uw	2233	11	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	2233	12	the	the	DT
cord-001835-0s7ok4uw	2233	13	formation	formation	NN
cord-001835-0s7ok4uw	2233	14	of	of	IN
cord-001835-0s7ok4uw	2233	15	CsgA	CsgA	NNP
cord-001835-0s7ok4uw	2233	16	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2233	17	fibers	fiber	NNS
cord-001835-0s7ok4uw	2233	18	in	in	IN
cord-001835-0s7ok4uw	2233	19	vitro	vitro	FW
cord-001835-0s7ok4uw	2233	20	.	.	.
cord-001835-0s7ok4uw	2234	1	This	this	DT
cord-001835-0s7ok4uw	2234	2	work	work	NN
cord-001835-0s7ok4uw	2234	3	illustrates	illustrate	VBZ
cord-001835-0s7ok4uw	2234	4	an	an	DT
cord-001835-0s7ok4uw	2234	5	alternative	alternative	JJ
cord-001835-0s7ok4uw	2234	6	approach	approach	NN
cord-001835-0s7ok4uw	2234	7	towards	towards	IN
cord-001835-0s7ok4uw	2234	8	biofilm	biofilm	NN
cord-001835-0s7ok4uw	2234	9	treatment	treatment	NN
cord-001835-0s7ok4uw	2234	10	at	at	IN
cord-001835-0s7ok4uw	2234	11	a	a	DT
cord-001835-0s7ok4uw	2234	12	molecular	molecular	JJ
cord-001835-0s7ok4uw	2234	13	level	level	NN
cord-001835-0s7ok4uw	2234	14	.	.	.
cord-001835-0s7ok4uw	2235	1	Coupled	coupled	JJ
cord-001835-0s7ok4uw	2235	2	folding	folding	NN
cord-001835-0s7ok4uw	2235	3	and	and	CC
cord-001835-0s7ok4uw	2235	4	binding	binding	NN
cord-001835-0s7ok4uw	2235	5	of	of	IN
cord-001835-0s7ok4uw	2235	6	transcription	transcription	NN
cord-001835-0s7ok4uw	2235	7	factors	factor	NNS
cord-001835-0s7ok4uw	2235	8	Sarah	Sarah	NNP
cord-001835-0s7ok4uw	2235	9	Shammas	Shammas	NNP
cord-001835-0s7ok4uw	2235	10	1	1	CD
cord-001835-0s7ok4uw	2235	11	,	,	,
cord-001835-0s7ok4uw	2235	12	Alexandra	Alexandra	NNP
cord-001835-0s7ok4uw	2235	13	Travis	Travis	NNP
cord-001835-0s7ok4uw	2235	14	1	1	CD
cord-001835-0s7ok4uw	2236	1	,	,	,
cord-001835-0s7ok4uw	2236	2	Jane	Jane	NNP
cord-001835-0s7ok4uw	2236	3	Clarke	Clarke	NNP
cord-001835-0s7ok4uw	2236	4	1	1	CD
cord-001835-0s7ok4uw	2236	5	1	1	CD
cord-001835-0s7ok4uw	2236	6	Intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	2236	7	protein	protein	NN
cord-001835-0s7ok4uw	2236	8	disorder	disorder	NN
cord-001835-0s7ok4uw	2236	9	is	be	VBZ
cord-001835-0s7ok4uw	2236	10	ubiquitous	ubiquitous	JJ
cord-001835-0s7ok4uw	2236	11	in	in	IN
cord-001835-0s7ok4uw	2236	12	transcription	transcription	NN
cord-001835-0s7ok4uw	2236	13	,	,	,
cord-001835-0s7ok4uw	2236	14	particularly	particularly	RB
cord-001835-0s7ok4uw	2236	15	within	within	IN
cord-001835-0s7ok4uw	2236	16	transcription	transcription	NN
cord-001835-0s7ok4uw	2236	17	factors	factor	NNS
cord-001835-0s7ok4uw	2236	18	,	,	,
cord-001835-0s7ok4uw	2236	19	which	which	WDT
cord-001835-0s7ok4uw	2236	20	frequently	frequently	RB
cord-001835-0s7ok4uw	2236	21	fold	fold	VBP
cord-001835-0s7ok4uw	2236	22	into	into	IN
cord-001835-0s7ok4uw	2236	23	structures	structure	NNS
cord-001835-0s7ok4uw	2236	24	upon	upon	IN
cord-001835-0s7ok4uw	2236	25	binding	bind	VBG
cord-001835-0s7ok4uw	2236	26	to	to	IN
cord-001835-0s7ok4uw	2236	27	partner	partner	NN
cord-001835-0s7ok4uw	2236	28	molecules	molecule	NNS
cord-001835-0s7ok4uw	2236	29	(	(	-LRB-
cord-001835-0s7ok4uw	2236	30	DNA	dna	NN
cord-001835-0s7ok4uw	2236	31	or	or	CC
cord-001835-0s7ok4uw	2236	32	protein	protein	NN
cord-001835-0s7ok4uw	2236	33	)	)	-RRB-
cord-001835-0s7ok4uw	2236	34	.	.	.
cord-001835-0s7ok4uw	2237	1	The	the	DT
cord-001835-0s7ok4uw	2237	2	coupled	coupled	JJ
cord-001835-0s7ok4uw	2237	3	folding	folding	NN
cord-001835-0s7ok4uw	2237	4	and	and	CC
cord-001835-0s7ok4uw	2237	5	binding	bind	VBG
cord-001835-0s7ok4uw	2237	6	reactions	reaction	NNS
cord-001835-0s7ok4uw	2237	7	that	that	WDT
cord-001835-0s7ok4uw	2237	8	take	take	VBP
cord-001835-0s7ok4uw	2237	9	place	place	NN
cord-001835-0s7ok4uw	2237	10	between	between	IN
cord-001835-0s7ok4uw	2237	11	individual	individual	JJ
cord-001835-0s7ok4uw	2237	12	transcription	transcription	NN
cord-001835-0s7ok4uw	2237	13	factors	factor	NNS
cord-001835-0s7ok4uw	2237	14	and	and	CC
cord-001835-0s7ok4uw	2237	15	the	the	DT
cord-001835-0s7ok4uw	2237	16	key	key	JJ
cord-001835-0s7ok4uw	2237	17	hub	hub	NN
cord-001835-0s7ok4uw	2237	18	co	co	NN
cord-001835-0s7ok4uw	2237	19	-	-	NN
cord-001835-0s7ok4uw	2237	20	activator	activator	NN
cord-001835-0s7ok4uw	2237	21	proteins	protein	NNS
cord-001835-0s7ok4uw	2237	22	are	be	VBP
cord-001835-0s7ok4uw	2237	23	crucial	crucial	JJ
cord-001835-0s7ok4uw	2237	24	in	in	IN
cord-001835-0s7ok4uw	2237	25	determining	determine	VBG
cord-001835-0s7ok4uw	2237	26	the	the	DT
cord-001835-0s7ok4uw	2237	27	expression	expression	NN
cord-001835-0s7ok4uw	2237	28	profile	profile	NN
cord-001835-0s7ok4uw	2237	29	of	of	IN
cord-001835-0s7ok4uw	2237	30	the	the	DT
cord-001835-0s7ok4uw	2237	31	cell	cell	NN
cord-001835-0s7ok4uw	2237	32	,	,	,
cord-001835-0s7ok4uw	2237	33	and	and	CC
cord-001835-0s7ok4uw	2237	34	hence	hence	RB
cord-001835-0s7ok4uw	2237	35	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2237	36	phenotype	phenotype	NN
cord-001835-0s7ok4uw	2237	37	.	.	.
cord-001835-0s7ok4uw	2238	1	These	these	DT
cord-001835-0s7ok4uw	2238	2	interactions	interaction	NNS
cord-001835-0s7ok4uw	2238	3	have	have	VBP
cord-001835-0s7ok4uw	2238	4	been	be	VBN
cord-001835-0s7ok4uw	2238	5	well	well	RB
cord-001835-0s7ok4uw	2238	6	studied	study	VBN
cord-001835-0s7ok4uw	2238	7	by	by	IN
cord-001835-0s7ok4uw	2238	8	structural	structural	JJ
cord-001835-0s7ok4uw	2238	9	and	and	CC
cord-001835-0s7ok4uw	2238	10	equilibrium	equilibrium	JJ
cord-001835-0s7ok4uw	2238	11	methods	method	NNS
cord-001835-0s7ok4uw	2238	12	.	.	.
cord-001835-0s7ok4uw	2239	1	Here	here	RB
cord-001835-0s7ok4uw	2239	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2239	3	present	present	VBP
cord-001835-0s7ok4uw	2239	4	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	2239	5	insights	insight	NNS
cord-001835-0s7ok4uw	2239	6	into	into	IN
cord-001835-0s7ok4uw	2239	7	the	the	DT
cord-001835-0s7ok4uw	2239	8	process	process	NN
cord-001835-0s7ok4uw	2239	9	,	,	,
cord-001835-0s7ok4uw	2239	10	gained	gain	VBD
cord-001835-0s7ok4uw	2239	11	through	through	IN
cord-001835-0s7ok4uw	2239	12	complementary	complementary	JJ
cord-001835-0s7ok4uw	2239	13	kinetics	kinetics	NN
cord-001835-0s7ok4uw	2239	14	experiments	experiment	NNS
cord-001835-0s7ok4uw	2239	15	,	,	,
cord-001835-0s7ok4uw	2239	16	for	for	IN
cord-001835-0s7ok4uw	2239	17	the	the	DT
cord-001835-0s7ok4uw	2239	18	binding	binding	NN
cord-001835-0s7ok4uw	2239	19	of	of	IN
cord-001835-0s7ok4uw	2239	20	five	five	CD
cord-001835-0s7ok4uw	2239	21	separate	separate	JJ
cord-001835-0s7ok4uw	2239	22	transcription	transcription	NN
cord-001835-0s7ok4uw	2239	23	factors	factor	NNS
cord-001835-0s7ok4uw	2239	24	to	to	IN
cord-001835-0s7ok4uw	2239	25	a	a	DT
cord-001835-0s7ok4uw	2239	26	single	single	JJ
cord-001835-0s7ok4uw	2239	27	prototypical	prototypical	JJ
cord-001835-0s7ok4uw	2239	28	co	co	NN
cord-001835-0s7ok4uw	2239	29	-	-	NN
cord-001835-0s7ok4uw	2239	30	activator	activator	NN
cord-001835-0s7ok4uw	2239	31	(	(	-LRB-
cord-001835-0s7ok4uw	2239	32	CBP	CBP	NNP
cord-001835-0s7ok4uw	2239	33	KIX	KIX	NNP
cord-001835-0s7ok4uw	2239	34	)	)	-RRB-
cord-001835-0s7ok4uw	2239	35	.	.	.
cord-001835-0s7ok4uw	2240	1	The	the	DT
cord-001835-0s7ok4uw	2240	2	transcription	transcription	NN
cord-001835-0s7ok4uw	2240	3	factors	factor	NNS
cord-001835-0s7ok4uw	2240	4	investigated	investigate	VBN
cord-001835-0s7ok4uw	2240	5	belong	belong	VBP
cord-001835-0s7ok4uw	2240	6	to	to	IN
cord-001835-0s7ok4uw	2240	7	cellular	cellular	JJ
cord-001835-0s7ok4uw	2240	8	(	(	-LRB-
cord-001835-0s7ok4uw	2240	9	cMyb	cMyb	NNP
cord-001835-0s7ok4uw	2240	10	,	,	,
cord-001835-0s7ok4uw	2240	11	MLL	MLL	NNP
cord-001835-0s7ok4uw	2240	12	,	,	,
cord-001835-0s7ok4uw	2240	13	CREB	CREB	NNP
cord-001835-0s7ok4uw	2240	14	,	,	,
cord-001835-0s7ok4uw	2240	15	E2A	e2a	NN
cord-001835-0s7ok4uw	2240	16	)	)	-RRB-
cord-001835-0s7ok4uw	2240	17	and	and	CC
cord-001835-0s7ok4uw	2240	18	viral	viral	JJ
cord-001835-0s7ok4uw	2240	19	(	(	-LRB-
cord-001835-0s7ok4uw	2240	20	HTLV-1	HTLV-1	NNP
cord-001835-0s7ok4uw	2240	21	bLZ	bLZ	NNP
cord-001835-0s7ok4uw	2240	22	)	)	-RRB-
cord-001835-0s7ok4uw	2240	23	classes	class	NNS
cord-001835-0s7ok4uw	2240	24	.	.	.
cord-001835-0s7ok4uw	2241	1	These	these	DT
cord-001835-0s7ok4uw	2241	2	reactions	reaction	NNS
cord-001835-0s7ok4uw	2241	3	are	be	VBP
cord-001835-0s7ok4uw	2241	4	remarkably	remarkably	RB
cord-001835-0s7ok4uw	2241	5	fast	fast	JJ
cord-001835-0s7ok4uw	2241	6	;	;	:
cord-001835-0s7ok4uw	2241	7	after	after	IN
cord-001835-0s7ok4uw	2241	8	removing	remove	VBG
cord-001835-0s7ok4uw	2241	9	the	the	DT
cord-001835-0s7ok4uw	2241	10	effect	effect	NN
cord-001835-0s7ok4uw	2241	11	of	of	IN
cord-001835-0s7ok4uw	2241	12	long	long	JJ
cord-001835-0s7ok4uw	2241	13	-	-	HYPH
cord-001835-0s7ok4uw	2241	14	range	range	NN
cord-001835-0s7ok4uw	2241	15	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	2241	16	rate	rate	NN
cord-001835-0s7ok4uw	2241	17	enhancement	enhancement	NN
cord-001835-0s7ok4uw	2241	18	the	the	DT
cord-001835-0s7ok4uw	2241	19	association	association	NN
cord-001835-0s7ok4uw	2241	20	rate	rate	NN
cord-001835-0s7ok4uw	2241	21	constant	constant	NN
cord-001835-0s7ok4uw	2241	22	is	be	VBZ
cord-001835-0s7ok4uw	2241	23	still	still	RB
cord-001835-0s7ok4uw	2241	24	approximately	approximately	RB
cord-001835-0s7ok4uw	2241	25	2	2	CD
cord-001835-0s7ok4uw	2241	26	x	x	SYM
cord-001835-0s7ok4uw	2241	27	10	10	CD
cord-001835-0s7ok4uw	2241	28	7	7	CD
cord-001835-0s7ok4uw	2241	29	M-1s-1	M-1s-1	NNP
cord-001835-0s7ok4uw	2241	30	,	,	,
cord-001835-0s7ok4uw	2241	31	which	which	WDT
cord-001835-0s7ok4uw	2241	32	is	be	VBZ
cord-001835-0s7ok4uw	2241	33	just	just	RB
cord-001835-0s7ok4uw	2241	34	above	above	IN
cord-001835-0s7ok4uw	2241	35	the	the	DT
cord-001835-0s7ok4uw	2241	36	typically	typically	RB
cord-001835-0s7ok4uw	2241	37	quoted	quote	VBN
cord-001835-0s7ok4uw	2241	38	upper	upper	JJ
cord-001835-0s7ok4uw	2241	39	limit	limit	NN
cord-001835-0s7ok4uw	2241	40	for	for	IN
cord-001835-0s7ok4uw	2241	41	diffusion	diffusion	NN
cord-001835-0s7ok4uw	2241	42	-	-	HYPH
cord-001835-0s7ok4uw	2241	43	limited	limit	VBN
cord-001835-0s7ok4uw	2241	44	reactions	reaction	NNS
cord-001835-0s7ok4uw	2241	45	between	between	IN
cord-001835-0s7ok4uw	2241	46	pairs	pair	NNS
cord-001835-0s7ok4uw	2241	47	of	of	IN
cord-001835-0s7ok4uw	2241	48	proteins	protein	NNS
cord-001835-0s7ok4uw	2241	49	(	(	-LRB-
cord-001835-0s7ok4uw	2241	50	10	10	CD
cord-001835-0s7ok4uw	2241	51	5	5	CD
cord-001835-0s7ok4uw	2241	52	-10	-10	CD
cord-001835-0s7ok4uw	2241	53	6	6	CD
cord-001835-0s7ok4uw	2241	54	M-1s-1	M-1s-1	NNP
cord-001835-0s7ok4uw	2241	55	)	)	-RRB-
cord-001835-0s7ok4uw	2241	56	,	,	,
cord-001835-0s7ok4uw	2241	57	and	and	CC
cord-001835-0s7ok4uw	2241	58	is	be	VBZ
cord-001835-0s7ok4uw	2241	59	also	also	RB
cord-001835-0s7ok4uw	2241	60	the	the	DT
cord-001835-0s7ok4uw	2241	61	highest	high	JJS
cord-001835-0s7ok4uw	2241	62	such	such	JJ
cord-001835-0s7ok4uw	2241	63	value	value	NN
cord-001835-0s7ok4uw	2241	64	we	-PRON-	PRP
cord-001835-0s7ok4uw	2241	65	have	have	VBP
cord-001835-0s7ok4uw	2241	66	found	find	VBN
cord-001835-0s7ok4uw	2241	67	reported	report	VBN
cord-001835-0s7ok4uw	2241	68	.	.	.
cord-001835-0s7ok4uw	2242	1	This	this	DT
cord-001835-0s7ok4uw	2242	2	,	,	,
cord-001835-0s7ok4uw	2242	3	combined	combine	VBN
cord-001835-0s7ok4uw	2242	4	with	with	IN
cord-001835-0s7ok4uw	2242	5	the	the	DT
cord-001835-0s7ok4uw	2242	6	apparent	apparent	JJ
cord-001835-0s7ok4uw	2242	7	insensitivity	insensitivity	NN
cord-001835-0s7ok4uw	2242	8	of	of	IN
cord-001835-0s7ok4uw	2242	9	the	the	DT
cord-001835-0s7ok4uw	2242	10	association	association	NN
cord-001835-0s7ok4uw	2242	11	rate	rate	NN
cord-001835-0s7ok4uw	2242	12	to	to	IN
cord-001835-0s7ok4uw	2242	13	residual	residual	JJ
cord-001835-0s7ok4uw	2242	14	structure	structure	NN
cord-001835-0s7ok4uw	2242	15	within	within	IN
cord-001835-0s7ok4uw	2242	16	the	the	DT
cord-001835-0s7ok4uw	2242	17	unbound	unbound	JJ
cord-001835-0s7ok4uw	2242	18	state	state	NN
cord-001835-0s7ok4uw	2242	19	,	,	,
cord-001835-0s7ok4uw	2242	20	indicates	indicate	VBZ
cord-001835-0s7ok4uw	2242	21	that	that	IN
cord-001835-0s7ok4uw	2242	22	binding	bind	VBG
cord-001835-0s7ok4uw	2242	23	preceeds	preceeds	NN
cord-001835-0s7ok4uw	2242	24	folding	fold	VBG
cord-001835-0s7ok4uw	2242	25	(	(	-LRB-
cord-001835-0s7ok4uw	2242	26	induced	induce	VBN
cord-001835-0s7ok4uw	2242	27	fit	fit	JJ
cord-001835-0s7ok4uw	2242	28	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2242	29	)	)	-RRB-
cord-001835-0s7ok4uw	2242	30	.	.	.
cord-001835-0s7ok4uw	2243	1	Interactions	interaction	NNS
cord-001835-0s7ok4uw	2243	2	between	between	IN
cord-001835-0s7ok4uw	2243	3	KIX	KIX	NNP
cord-001835-0s7ok4uw	2243	4	and	and	CC
cord-001835-0s7ok4uw	2243	5	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2243	6	transcription	transcription	NN
cord-001835-0s7ok4uw	2243	7	factors	factor	NNS
cord-001835-0s7ok4uw	2243	8	are	be	VBP
cord-001835-0s7ok4uw	2243	9	additionally	additionally	RB
cord-001835-0s7ok4uw	2243	10	modulated	modulate	VBN
cord-001835-0s7ok4uw	2243	11	by	by	IN
cord-001835-0s7ok4uw	2243	12	allostery	allostery	NN
cord-001835-0s7ok4uw	2243	13	between	between	IN
cord-001835-0s7ok4uw	2243	14	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2243	15	two	two	CD
cord-001835-0s7ok4uw	2243	16	binding	bind	VBG
cord-001835-0s7ok4uw	2243	17	sites	site	NNS
cord-001835-0s7ok4uw	2243	18	.	.	.
cord-001835-0s7ok4uw	2244	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2244	2	investigate	investigate	VBP
cord-001835-0s7ok4uw	2244	3	the	the	DT
cord-001835-0s7ok4uw	2244	4	basis	basis	NN
cord-001835-0s7ok4uw	2244	5	for	for	IN
cord-001835-0s7ok4uw	2244	6	this	this	DT
cord-001835-0s7ok4uw	2244	7	,	,	,
cord-001835-0s7ok4uw	2244	8	finding	find	VBG
cord-001835-0s7ok4uw	2244	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	2244	10	to	to	TO
cord-001835-0s7ok4uw	2244	11	be	be	VB
cord-001835-0s7ok4uw	2244	12	mediated	mediate	VBN
cord-001835-0s7ok4uw	2244	13	by	by	IN
cord-001835-0s7ok4uw	2244	14	changes	change	NNS
cord-001835-0s7ok4uw	2244	15	in	in	IN
cord-001835-0s7ok4uw	2244	16	protein	protein	NN
cord-001835-0s7ok4uw	2244	17	flexibility	flexibility	NN
cord-001835-0s7ok4uw	2244	18	.	.	.
cord-001835-0s7ok4uw	2245	1	Alternative	alternative	JJ
cord-001835-0s7ok4uw	2245	2	hit	hit	VBD
cord-001835-0s7ok4uw	2245	3	finding	find	VBG
cord-001835-0s7ok4uw	2245	4	strategies	strategy	NNS
cord-001835-0s7ok4uw	2245	5	for	for	IN
cord-001835-0s7ok4uw	2245	6	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2245	7	disordered	disordered	JJ
cord-001835-0s7ok4uw	2245	8	proteins	protein	NNS
cord-001835-0s7ok4uw	2245	9	,	,	,
cord-001835-0s7ok4uw	2245	10	exemplified	exemplify	VBN
cord-001835-0s7ok4uw	2245	11	by	by	IN
cord-001835-0s7ok4uw	2245	12	forkheadbox	forkheadbox	NN
cord-001835-0s7ok4uw	2245	13	transcription	transcription	NN
cord-001835-0s7ok4uw	2245	14	factors	factor	NNS
cord-001835-0s7ok4uw	2245	15	Harm	Harm	NNP
cord-001835-0s7ok4uw	2245	16	Jan	Jan	NNP
cord-001835-0s7ok4uw	2245	17	(	(	-LRB-
cord-001835-0s7ok4uw	2245	18	Arjan	Arjan	NNP
cord-001835-0s7ok4uw	2245	19	)	)	-RRB-
cord-001835-0s7ok4uw	2245	20	Snijder	snijder	NN
cord-001835-0s7ok4uw	2245	21	1	1	CD
cord-001835-0s7ok4uw	2245	22	,	,	,
cord-001835-0s7ok4uw	2245	23	Maria	Maria	NNP
cord-001835-0s7ok4uw	2245	24	Saline	Saline	NNP
cord-001835-0s7ok4uw	2245	25	1	1	CD
cord-001835-0s7ok4uw	2245	26	,	,	,
cord-001835-0s7ok4uw	2245	27	Tomas	Tomas	NNP
cord-001835-0s7ok4uw	2245	28	Jacso	Jacso	NNP
cord-001835-0s7ok4uw	2245	29	1	1	CD
cord-001835-0s7ok4uw	2245	30	,	,	,
cord-001835-0s7ok4uw	2245	31	Frank	Frank	NNP
cord-001835-0s7ok4uw	2245	32	Janssen	Janssen	NNP
cord-001835-0s7ok4uw	2245	33	1	1	CD
cord-001835-0s7ok4uw	2245	34	,	,	,
cord-001835-0s7ok4uw	2245	35	Mattias	Mattias	NNP
cord-001835-0s7ok4uw	2245	36	Rohman	Rohman	NNP
cord-001835-0s7ok4uw	2245	37	1	1	CD
cord-001835-0s7ok4uw	2245	38	,	,	,
cord-001835-0s7ok4uw	2245	39	Tyrrell	Tyrrell	NNP
cord-001835-0s7ok4uw	2245	40	Norris	Norris	NNP
cord-001835-0s7ok4uw	2245	41	1	1	CD
cord-001835-0s7ok4uw	2245	42	1	1	CD
cord-001835-0s7ok4uw	2245	43	Astrazeneca	Astrazeneca	NNP
cord-001835-0s7ok4uw	2245	44	R&D	R&D	NNP
cord-001835-0s7ok4uw	2245	45	,	,	,
cord-001835-0s7ok4uw	2245	46	Discovery	Discovery	NNP
cord-001835-0s7ok4uw	2245	47	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	2245	48	,	,	,
cord-001835-0s7ok4uw	2246	1	SE-431	SE-431	NNP
cord-001835-0s7ok4uw	2246	2	83,Pepparedsleden	83,pepparedsleden	CD
cord-001835-0s7ok4uw	2247	1	1	1	CD
cord-001835-0s7ok4uw	2247	2	Forkhead	Forkhead	NNP
cord-001835-0s7ok4uw	2247	3	box	box	NN
cord-001835-0s7ok4uw	2247	4	O	o	NN
cord-001835-0s7ok4uw	2247	5	(	(	-LRB-
cord-001835-0s7ok4uw	2247	6	FOXO	FOXO	NNP
cord-001835-0s7ok4uw	2247	7	)	)	-RRB-
cord-001835-0s7ok4uw	2247	8	proteins	protein	NNS
cord-001835-0s7ok4uw	2247	9	are	be	VBP
cord-001835-0s7ok4uw	2247	10	emerging	emerge	VBG
cord-001835-0s7ok4uw	2247	11	as	as	IN
cord-001835-0s7ok4uw	2247	12	key	key	JJ
cord-001835-0s7ok4uw	2247	13	transcription	transcription	NN
cord-001835-0s7ok4uw	2247	14	factors	factor	NNS
cord-001835-0s7ok4uw	2247	15	in	in	IN
cord-001835-0s7ok4uw	2247	16	insulin	insulin	NN
cord-001835-0s7ok4uw	2247	17	and	and	CC
cord-001835-0s7ok4uw	2247	18	glucose	glucose	NN
cord-001835-0s7ok4uw	2247	19	metabolism	metabolism	NN
cord-001835-0s7ok4uw	2247	20	,	,	,
cord-001835-0s7ok4uw	2247	21	regulation	regulation	NN
cord-001835-0s7ok4uw	2247	22	of	of	IN
cord-001835-0s7ok4uw	2247	23	immune	immune	JJ
cord-001835-0s7ok4uw	2247	24	responses	response	NNS
cord-001835-0s7ok4uw	2247	25	,	,	,
cord-001835-0s7ok4uw	2247	26	and	and	CC
cord-001835-0s7ok4uw	2247	27	to	to	TO
cord-001835-0s7ok4uw	2247	28	balance	balance	VB
cord-001835-0s7ok4uw	2247	29	cell	cell	NN
cord-001835-0s7ok4uw	2247	30	proliferation	proliferation	NN
cord-001835-0s7ok4uw	2247	31	,	,	,
cord-001835-0s7ok4uw	2247	32	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	2247	33	and	and	CC
cord-001835-0s7ok4uw	2247	34	senescence	senescence	NN
cord-001835-0s7ok4uw	2247	35	.	.	.
cord-001835-0s7ok4uw	2248	1	FOXO	foxo	NN
cord-001835-0s7ok4uw	2248	2	proteins	protein	NNS
cord-001835-0s7ok4uw	2248	3	are	be	VBP
cord-001835-0s7ok4uw	2248	4	predicted	predict	VBN
cord-001835-0s7ok4uw	2248	5	to	to	TO
cord-001835-0s7ok4uw	2248	6	be	be	VB
cord-001835-0s7ok4uw	2248	7	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2248	8	disordered	disordered	JJ
cord-001835-0s7ok4uw	2248	9	proteins	protein	NNS
cord-001835-0s7ok4uw	2248	10	(	(	-LRB-
cord-001835-0s7ok4uw	2248	11	IDPs	IDPs	NNP
cord-001835-0s7ok4uw	2248	12	)	)	-RRB-
cord-001835-0s7ok4uw	2248	13	;	;	:
cord-001835-0s7ok4uw	2248	14	IDPs	IDPs	NNP
cord-001835-0s7ok4uw	2248	15	are	be	VBP
cord-001835-0s7ok4uw	2248	16	largely	largely	RB
cord-001835-0s7ok4uw	2248	17	unstructured	unstructured	JJ
cord-001835-0s7ok4uw	2248	18	and	and	CC
cord-001835-0s7ok4uw	2248	19	often	often	RB
cord-001835-0s7ok4uw	2248	20	function	function	VBP
cord-001835-0s7ok4uw	2248	21	as	as	IN
cord-001835-0s7ok4uw	2248	22	hubs	hub	NNS
cord-001835-0s7ok4uw	2248	23	mediating	mediate	VBG
cord-001835-0s7ok4uw	2248	24	multiple	multiple	JJ
cord-001835-0s7ok4uw	2248	25	interactions	interaction	NNS
cord-001835-0s7ok4uw	2248	26	.	.	.
cord-001835-0s7ok4uw	2249	1	IDPs	IDPs	NNP
cord-001835-0s7ok4uw	2249	2	are	be	VBP
cord-001835-0s7ok4uw	2249	3	considered	consider	VBN
cord-001835-0s7ok4uw	2249	4	to	to	TO
cord-001835-0s7ok4uw	2249	5	be	be	VB
cord-001835-0s7ok4uw	2249	6	largely	largely	RB
cord-001835-0s7ok4uw	2249	7	evasive	evasive	JJ
cord-001835-0s7ok4uw	2249	8	from	from	IN
cord-001835-0s7ok4uw	2249	9	classical	classical	JJ
cord-001835-0s7ok4uw	2249	10	small	small	JJ
cord-001835-0s7ok4uw	2249	11	molecule	molecule	NN
cord-001835-0s7ok4uw	2249	12	interference	interference	NN
cord-001835-0s7ok4uw	2249	13	and	and	CC
cord-001835-0s7ok4uw	2249	14	lead	lead	NN
cord-001835-0s7ok4uw	2249	15	-	-	HYPH
cord-001835-0s7ok4uw	2249	16	generation	generation	NN
cord-001835-0s7ok4uw	2249	17	approaches	approach	NNS
cord-001835-0s7ok4uw	2249	18	,	,	,
cord-001835-0s7ok4uw	2249	19	as	as	IN
cord-001835-0s7ok4uw	2249	20	they	-PRON-	PRP
cord-001835-0s7ok4uw	2249	21	lack	lack	VBP
cord-001835-0s7ok4uw	2249	22	defined	define	VBN
cord-001835-0s7ok4uw	2249	23	binding	bind	VBG
cord-001835-0s7ok4uw	2249	24	pockets	pocket	NNS
cord-001835-0s7ok4uw	2249	25	.	.	.
cord-001835-0s7ok4uw	2250	1	The	the	DT
cord-001835-0s7ok4uw	2250	2	available	available	JJ
cord-001835-0s7ok4uw	2250	3	methods	method	NNS
cord-001835-0s7ok4uw	2250	4	for	for	IN
cord-001835-0s7ok4uw	2250	5	addressing	address	VBG
cord-001835-0s7ok4uw	2250	6	these	these	DT
cord-001835-0s7ok4uw	2250	7	targets	target	NNS
cord-001835-0s7ok4uw	2250	8	have	have	VBP
cord-001835-0s7ok4uw	2250	9	been	be	VBN
cord-001835-0s7ok4uw	2250	10	lagging	lag	VBG
cord-001835-0s7ok4uw	2250	11	behind	behind	RB
cord-001835-0s7ok4uw	2250	12	and	and	CC
cord-001835-0s7ok4uw	2250	13	needs	need	VBZ
cord-001835-0s7ok4uw	2250	14	to	to	TO
cord-001835-0s7ok4uw	2250	15	be	be	VB
cord-001835-0s7ok4uw	2250	16	developed	develop	VBN
cord-001835-0s7ok4uw	2250	17	to	to	TO
cord-001835-0s7ok4uw	2250	18	assess	assess	VB
cord-001835-0s7ok4uw	2250	19	tractability	tractability	NN
cord-001835-0s7ok4uw	2250	20	of	of	IN
cord-001835-0s7ok4uw	2250	21	this	this	DT
cord-001835-0s7ok4uw	2250	22	target	target	NN
cord-001835-0s7ok4uw	2250	23	class	class	NN
cord-001835-0s7ok4uw	2250	24	.	.	.
cord-001835-0s7ok4uw	2251	1	Here	here	RB
cord-001835-0s7ok4uw	2251	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2251	3	have	have	VBP
cord-001835-0s7ok4uw	2251	4	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	2251	5	the	the	DT
cord-001835-0s7ok4uw	2251	6	tractability	tractability	NN
cord-001835-0s7ok4uw	2251	7	of	of	IN
cord-001835-0s7ok4uw	2251	8	fragment	fragment	NN
cord-001835-0s7ok4uw	2251	9	screening	screening	NN
cord-001835-0s7ok4uw	2251	10	on	on	IN
cord-001835-0s7ok4uw	2251	11	various	various	JJ
cord-001835-0s7ok4uw	2251	12	domains	domain	NNS
cord-001835-0s7ok4uw	2251	13	of	of	IN
cord-001835-0s7ok4uw	2251	14	a	a	DT
cord-001835-0s7ok4uw	2251	15	Forkhead	Forkhead	NNP
cord-001835-0s7ok4uw	2251	16	box	box	NN
cord-001835-0s7ok4uw	2251	17	O	o	NN
cord-001835-0s7ok4uw	2251	18	member	member	NN
cord-001835-0s7ok4uw	2251	19	.	.	.
cord-001835-0s7ok4uw	2252	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2252	2	could	could	MD
cord-001835-0s7ok4uw	2252	3	confirm	confirm	VB
cord-001835-0s7ok4uw	2252	4	the	the	DT
cord-001835-0s7ok4uw	2252	5	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2252	6	disordered	disordered	JJ
cord-001835-0s7ok4uw	2252	7	character	character	NN
cord-001835-0s7ok4uw	2252	8	of	of	IN
cord-001835-0s7ok4uw	2252	9	FOXO	FOXO	NNP
cord-001835-0s7ok4uw	2252	10	and	and	CC
cord-001835-0s7ok4uw	2252	11	used	use	VBD
cord-001835-0s7ok4uw	2252	12	NMR	nmr	NN
cord-001835-0s7ok4uw	2252	13	screening	screening	NN
cord-001835-0s7ok4uw	2252	14	to	to	TO
cord-001835-0s7ok4uw	2252	15	identify	identify	VB
cord-001835-0s7ok4uw	2252	16	fragments	fragment	NNS
cord-001835-0s7ok4uw	2252	17	that	that	WDT
cord-001835-0s7ok4uw	2252	18	interact	interact	VBP
cord-001835-0s7ok4uw	2252	19	with	with	IN
cord-001835-0s7ok4uw	2252	20	FOXO	FOXO	NNP
cord-001835-0s7ok4uw	2252	21	.	.	.
cord-001835-0s7ok4uw	2253	1	One	one	CD
cord-001835-0s7ok4uw	2253	2	of	of	IN
cord-001835-0s7ok4uw	2253	3	these	these	DT
cord-001835-0s7ok4uw	2253	4	fragments	fragment	NNS
cord-001835-0s7ok4uw	2253	5	was	be	VBD
cord-001835-0s7ok4uw	2253	6	subsequently	subsequently	RB
cord-001835-0s7ok4uw	2253	7	confirmed	confirm	VBN
cord-001835-0s7ok4uw	2253	8	as	as	IN
cord-001835-0s7ok4uw	2253	9	a	a	DT
cord-001835-0s7ok4uw	2253	10	direct	direct	JJ
cord-001835-0s7ok4uw	2253	11	FOXO	foxo	NN
cord-001835-0s7ok4uw	2253	12	binder	binder	NN
cord-001835-0s7ok4uw	2253	13	in	in	IN
cord-001835-0s7ok4uw	2253	14	2D	2D	NNP
cord-001835-0s7ok4uw	2253	15	HSQC	HSQC	NNP
cord-001835-0s7ok4uw	2253	16	-	-	HYPH
cord-001835-0s7ok4uw	2253	17	NMR	NMR	NNP
cord-001835-0s7ok4uw	2253	18	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2253	19	and	and	CC
cord-001835-0s7ok4uw	2253	20	this	this	DT
cord-001835-0s7ok4uw	2253	21	fragment	fragment	NN
cord-001835-0s7ok4uw	2253	22	showed	show	VBD
cord-001835-0s7ok4uw	2253	23	an	an	DT
cord-001835-0s7ok4uw	2253	24	effect	effect	NN
cord-001835-0s7ok4uw	2253	25	in	in	IN
cord-001835-0s7ok4uw	2253	26	a	a	DT
cord-001835-0s7ok4uw	2253	27	FOXO	FOXO	NNP
cord-001835-0s7ok4uw	2253	28	reporter	reporter	NN
cord-001835-0s7ok4uw	2253	29	gene	gene	NN
cord-001835-0s7ok4uw	2253	30	assay	assay	NN
cord-001835-0s7ok4uw	2253	31	.	.	.
cord-001835-0s7ok4uw	2254	1	These	these	DT
cord-001835-0s7ok4uw	2254	2	results	result	NNS
cord-001835-0s7ok4uw	2254	3	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	2254	4	that	that	DT
cord-001835-0s7ok4uw	2254	5	fragment	fragment	NN
cord-001835-0s7ok4uw	2254	6	screening	screening	NN
cord-001835-0s7ok4uw	2254	7	may	may	MD
cord-001835-0s7ok4uw	2254	8	be	be	VB
cord-001835-0s7ok4uw	2254	9	a	a	DT
cord-001835-0s7ok4uw	2254	10	valuable	valuable	JJ
cord-001835-0s7ok4uw	2254	11	approach	approach	NN
cord-001835-0s7ok4uw	2254	12	for	for	IN
cord-001835-0s7ok4uw	2254	13	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2254	14	disordered	disordered	JJ
cord-001835-0s7ok4uw	2254	15	proteins	protein	NNS
cord-001835-0s7ok4uw	2254	16	although	although	IN
cord-001835-0s7ok4uw	2254	17	challenges	challenge	NNS
cord-001835-0s7ok4uw	2254	18	remain	remain	VBP
cord-001835-0s7ok4uw	2254	19	to	to	TO
cord-001835-0s7ok4uw	2254	20	expand	expand	VB
cord-001835-0s7ok4uw	2254	21	these	these	DT
cord-001835-0s7ok4uw	2254	22	fragments	fragment	NNS
cord-001835-0s7ok4uw	2254	23	into	into	IN
cord-001835-0s7ok4uw	2254	24	more	more	RBR
cord-001835-0s7ok4uw	2254	25	potent	potent	JJ
cord-001835-0s7ok4uw	2254	26	hits	hit	NNS
cord-001835-0s7ok4uw	2254	27	in	in	IN
cord-001835-0s7ok4uw	2254	28	the	the	DT
cord-001835-0s7ok4uw	2254	29	absence	absence	NN
cord-001835-0s7ok4uw	2254	30	of	of	IN
cord-001835-0s7ok4uw	2254	31	detailed	detailed	JJ
cord-001835-0s7ok4uw	2254	32	structural	structural	JJ
cord-001835-0s7ok4uw	2254	33	data	datum	NNS
cord-001835-0s7ok4uw	2254	34	.	.	.
cord-001835-0s7ok4uw	2255	1	The	the	DT
cord-001835-0s7ok4uw	2255	2	characterization	characterization	NN
cord-001835-0s7ok4uw	2255	3	of	of	IN
cord-001835-0s7ok4uw	2255	4	amyloid	amyloid	JJ
cord-001835-0s7ok4uw	2255	5	-	-	HYPH
cord-001835-0s7ok4uw	2255	6	beta	beta	NN
cord-001835-0s7ok4uw	2255	7	peptide	peptide	NN
cord-001835-0s7ok4uw	2255	8	(	(	-LRB-
cord-001835-0s7ok4uw	2255	9	Abeta	Abeta	NNP
cord-001835-0s7ok4uw	2255	10	)	)	-RRB-
cord-001835-0s7ok4uw	2255	11	oligomer	oligomer	NNP
cord-001835-0s7ok4uw	2255	12	samples	sample	NNS
cord-001835-0s7ok4uw	2255	13	is	be	VBZ
cord-001835-0s7ok4uw	2255	14	critical	critical	JJ
cord-001835-0s7ok4uw	2255	15	to	to	TO
cord-001835-0s7ok4uw	2255	16	advance	advance	VB
cord-001835-0s7ok4uw	2255	17	in	in	IN
cord-001835-0s7ok4uw	2255	18	the	the	DT
cord-001835-0s7ok4uw	2255	19	field	field	NN
cord-001835-0s7ok4uw	2255	20	of	of	IN
cord-001835-0s7ok4uw	2255	21	Alzheime	Alzheime	NNP
cord-001835-0s7ok4uw	2255	22	rs	rs	NN
cord-001835-0s7ok4uw	2255	23	disease	disease	NN
cord-001835-0s7ok4uw	2255	24	(	(	-LRB-
cord-001835-0s7ok4uw	2255	25	AD	ad	NN
cord-001835-0s7ok4uw	2255	26	)	)	-RRB-
cord-001835-0s7ok4uw	2255	27	.	.	.
cord-001835-0s7ok4uw	2256	1	Here	here	RB
cord-001835-0s7ok4uw	2256	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2256	3	report	report	VBP
cord-001835-0s7ok4uw	2256	4	a	a	DT
cord-001835-0s7ok4uw	2256	5	critical	critical	JJ
cord-001835-0s7ok4uw	2256	6	evaluation	evaluation	NN
cord-001835-0s7ok4uw	2256	7	of	of	IN
cord-001835-0s7ok4uw	2256	8	two	two	CD
cord-001835-0s7ok4uw	2256	9	methods	method	NNS
cord-001835-0s7ok4uw	2256	10	used	use	VBN
cord-001835-0s7ok4uw	2256	11	for	for	IN
cord-001835-0s7ok4uw	2256	12	this	this	DT
cord-001835-0s7ok4uw	2256	13	purpose	purpose	NN
cord-001835-0s7ok4uw	2256	14	,	,	,
cord-001835-0s7ok4uw	2256	15	namely	namely	RB
cord-001835-0s7ok4uw	2256	16	sodium	sodium	NN
cord-001835-0s7ok4uw	2256	17	dodecyl	dodecyl	NNP
cord-001835-0s7ok4uw	2256	18	sulfate	sulfate	NN
cord-001835-0s7ok4uw	2256	19	polyacrylamide	polyacrylamide	NN
cord-001835-0s7ok4uw	2256	20	gel	gel	NN
cord-001835-0s7ok4uw	2256	21	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	2256	22	(	(	-LRB-
cord-001835-0s7ok4uw	2256	23	SDS	SDS	NNP
cord-001835-0s7ok4uw	2256	24	-	-	HYPH
cord-001835-0s7ok4uw	2256	25	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	2256	26	)	)	-RRB-
cord-001835-0s7ok4uw	2256	27	,	,	,
cord-001835-0s7ok4uw	2256	28	extensively	extensively	RB
cord-001835-0s7ok4uw	2256	29	used	use	VBN
cord-001835-0s7ok4uw	2256	30	in	in	IN
cord-001835-0s7ok4uw	2256	31	the	the	DT
cord-001835-0s7ok4uw	2256	32	field	field	NN
cord-001835-0s7ok4uw	2256	33	,	,	,
cord-001835-0s7ok4uw	2256	34	and	and	CC
cord-001835-0s7ok4uw	2256	35	electrospray	electrospray	JJ
cord-001835-0s7ok4uw	2256	36	ionization	ionization	NN
cord-001835-0s7ok4uw	2256	37	ion	ion	NN
cord-001835-0s7ok4uw	2256	38	mobility	mobility	NN
cord-001835-0s7ok4uw	2256	39	coupled	couple	VBN
cord-001835-0s7ok4uw	2256	40	to	to	IN
cord-001835-0s7ok4uw	2256	41	mass	mass	NN
cord-001835-0s7ok4uw	2256	42	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	2256	43	(	(	-LRB-
cord-001835-0s7ok4uw	2256	44	ESI	ESI	NNP
cord-001835-0s7ok4uw	2256	45	-	-	HYPH
cord-001835-0s7ok4uw	2256	46	IM	IM	NNP
cord-001835-0s7ok4uw	2256	47	-	-	HYPH
cord-001835-0s7ok4uw	2256	48	MS	MS	NNP
cord-001835-0s7ok4uw	2256	49	)	)	-RRB-
cord-001835-0s7ok4uw	2256	50	,	,	,
cord-001835-0s7ok4uw	2256	51	an	an	DT
cord-001835-0s7ok4uw	2256	52	emerging	emerge	VBG
cord-001835-0s7ok4uw	2256	53	technique	technique	NN
cord-001835-0s7ok4uw	2256	54	with	with	IN
cord-001835-0s7ok4uw	2256	55	great	great	JJ
cord-001835-0s7ok4uw	2256	56	potential	potential	NN
cord-001835-0s7ok4uw	2256	57	for	for	IN
cord-001835-0s7ok4uw	2256	58	oligomer	oligomer	NNP
cord-001835-0s7ok4uw	2256	59	characterization	characterization	NN
cord-001835-0s7ok4uw	2256	60	.	.	.
cord-001835-0s7ok4uw	2257	1	To	to	TO
cord-001835-0s7ok4uw	2257	2	evaluate	evaluate	VB
cord-001835-0s7ok4uw	2257	3	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2257	4	performance	performance	NN
cord-001835-0s7ok4uw	2257	5	,	,	,
cord-001835-0s7ok4uw	2257	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	2257	7	first	first	RB
cord-001835-0s7ok4uw	2257	8	obtained	obtain	VBD
cord-001835-0s7ok4uw	2257	9	pure	pure	JJ
cord-001835-0s7ok4uw	2257	10	cross	cross	NN
cord-001835-0s7ok4uw	2257	11	-	-	VBN
cord-001835-0s7ok4uw	2257	12	linked	link	VBN
cord-001835-0s7ok4uw	2257	13	Abeta40	Abeta40	NNP
cord-001835-0s7ok4uw	2257	14	and	and	CC
cord-001835-0s7ok4uw	2257	15	Abeta42	Abeta42	NNP
cord-001835-0s7ok4uw	2257	16	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2257	17	of	of	IN
cord-001835-0s7ok4uw	2257	18	specific	specific	JJ
cord-001835-0s7ok4uw	2257	19	order	order	NN
cord-001835-0s7ok4uw	2257	20	.	.	.
cord-001835-0s7ok4uw	2258	1	Analysis	analysis	NN
cord-001835-0s7ok4uw	2258	2	of	of	IN
cord-001835-0s7ok4uw	2258	3	these	these	DT
cord-001835-0s7ok4uw	2258	4	samples	sample	NNS
cord-001835-0s7ok4uw	2258	5	by	by	IN
cord-001835-0s7ok4uw	2258	6	SDS	SDS	NNP
cord-001835-0s7ok4uw	2258	7	-	-	HYPH
cord-001835-0s7ok4uw	2258	8	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	2258	9	revealed	reveal	VBD
cord-001835-0s7ok4uw	2258	10	that	that	IN
cord-001835-0s7ok4uw	2258	11	SDS	SDS	NNP
cord-001835-0s7ok4uw	2258	12	affects	affect	VBZ
cord-001835-0s7ok4uw	2258	13	the	the	DT
cord-001835-0s7ok4uw	2258	14	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	2258	15	state	state	NN
cord-001835-0s7ok4uw	2258	16	of	of	IN
cord-001835-0s7ok4uw	2258	17	Abeta42	Abeta42	NNP
cord-001835-0s7ok4uw	2258	18	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2258	19	,	,	,
cord-001835-0s7ok4uw	2258	20	thus	thus	RB
cord-001835-0s7ok4uw	2258	21	providing	provide	VBG
cord-001835-0s7ok4uw	2258	22	flawed	flawed	JJ
cord-001835-0s7ok4uw	2258	23	information	information	NN
cord-001835-0s7ok4uw	2258	24	on	on	IN
cord-001835-0s7ok4uw	2258	25	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2258	26	order	order	NN
cord-001835-0s7ok4uw	2258	27	and	and	CC
cord-001835-0s7ok4uw	2258	28	distribution	distribution	NN
cord-001835-0s7ok4uw	2258	29	.	.	.
cord-001835-0s7ok4uw	2259	1	In	in	IN
cord-001835-0s7ok4uw	2259	2	contrast	contrast	NN
cord-001835-0s7ok4uw	2259	3	,	,	,
cord-001835-0s7ok4uw	2259	4	ESI	ESI	NNP
cord-001835-0s7ok4uw	2259	5	-	-	HYPH
cord-001835-0s7ok4uw	2259	6	IM	IM	NNP
cord-001835-0s7ok4uw	2259	7	-	-	HYPH
cord-001835-0s7ok4uw	2259	8	MS	MS	NNP
cord-001835-0s7ok4uw	2259	9	provided	provide	VBD
cord-001835-0s7ok4uw	2259	10	accurate	accurate	JJ
cord-001835-0s7ok4uw	2259	11	information	information	NN
cord-001835-0s7ok4uw	2259	12	,	,	,
cord-001835-0s7ok4uw	2259	13	while	while	IN
cord-001835-0s7ok4uw	2259	14	also	also	RB
cord-001835-0s7ok4uw	2259	15	reported	report	VBD
cord-001835-0s7ok4uw	2259	16	on	on	IN
cord-001835-0s7ok4uw	2259	17	the	the	DT
cord-001835-0s7ok4uw	2259	18	chemical	chemical	JJ
cord-001835-0s7ok4uw	2259	19	modifications	modification	NNS
cord-001835-0s7ok4uw	2259	20	and	and	CC
cord-001835-0s7ok4uw	2259	21	on	on	IN
cord-001835-0s7ok4uw	2259	22	the	the	DT
cord-001835-0s7ok4uw	2259	23	structure	structure	NN
cord-001835-0s7ok4uw	2259	24	of	of	IN
cord-001835-0s7ok4uw	2259	25	the	the	DT
cord-001835-0s7ok4uw	2259	26	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2259	27	.	.	.
cord-001835-0s7ok4uw	2260	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2260	2	findings	finding	NNS
cord-001835-0s7ok4uw	2260	3	have	have	VBP
cord-001835-0s7ok4uw	2260	4	important	important	JJ
cord-001835-0s7ok4uw	2260	5	implications	implication	NNS
cord-001835-0s7ok4uw	2260	6	as	as	IN
cord-001835-0s7ok4uw	2260	7	they	-PRON-	PRP
cord-001835-0s7ok4uw	2260	8	challenge	challenge	VBP
cord-001835-0s7ok4uw	2260	9	scientific	scientific	JJ
cord-001835-0s7ok4uw	2260	10	paradigms	paradigm	NNS
cord-001835-0s7ok4uw	2260	11	in	in	IN
cord-001835-0s7ok4uw	2260	12	the	the	DT
cord-001835-0s7ok4uw	2260	13	AD	ad	NN
cord-001835-0s7ok4uw	2260	14	field	field	NN
cord-001835-0s7ok4uw	2260	15	built	build	VBN
cord-001835-0s7ok4uw	2260	16	upon	upon	IN
cord-001835-0s7ok4uw	2260	17	the	the	DT
cord-001835-0s7ok4uw	2260	18	SDS	SDS	NNP
cord-001835-0s7ok4uw	2260	19	-	-	HYPH
cord-001835-0s7ok4uw	2260	20	PAGE	page	NN
cord-001835-0s7ok4uw	2260	21	characterization	characterization	NN
cord-001835-0s7ok4uw	2260	22	of	of	IN
cord-001835-0s7ok4uw	2260	23	Abeta	Abeta	NNP
cord-001835-0s7ok4uw	2260	24	oligomer	oligomer	NN
cord-001835-0s7ok4uw	2260	25	samples	sample	NNS
cord-001835-0s7ok4uw	2260	26	.	.	.
cord-001835-0s7ok4uw	2261	1	Coarse	coarse	JJ
cord-001835-0s7ok4uw	2261	2	-	-	HYPH
cord-001835-0s7ok4uw	2261	3	grained	grained	JJ
cord-001835-0s7ok4uw	2261	4	simulation	simulation	NN
cord-001835-0s7ok4uw	2261	5	of	of	IN
cord-001835-0s7ok4uw	2261	6	protein	protein	NNP
cord-001835-0s7ok4uw	2261	7	association	association	NNP
cord-001835-0s7ok4uw	2261	8	:	:	:
cord-001835-0s7ok4uw	2261	9	application	application	NN
cord-001835-0s7ok4uw	2261	10	to	to	TO
cord-001835-0s7ok4uw	2261	11	rate	rate	VB
cord-001835-0s7ok4uw	2261	12	prediction	prediction	NN
cord-001835-0s7ok4uw	2261	13	and	and	CC
cord-001835-0s7ok4uw	2261	14	implication	implication	NN
cord-001835-0s7ok4uw	2261	15	for	for	IN
cord-001835-0s7ok4uw	2261	16	association	association	NN
cord-001835-0s7ok4uw	2261	17	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	2261	18	Yinghao	Yinghao	NNP
cord-001835-0s7ok4uw	2261	19	Wu	Wu	NNP
cord-001835-0s7ok4uw	2261	20	1	1	CD
cord-001835-0s7ok4uw	2261	21	,	,	,
cord-001835-0s7ok4uw	2262	1	1	1	CD
cord-001835-0s7ok4uw	2262	2	 	 	_SP
cord-001835-0s7ok4uw	2263	1	The	the	DT
cord-001835-0s7ok4uw	2263	2	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2263	3	of	of	IN
cord-001835-0s7ok4uw	2263	4	protein	protein	NN
cord-001835-0s7ok4uw	2263	5	binding	binding	NN
cord-001835-0s7ok4uw	2263	6	is	be	VBZ
cord-001835-0s7ok4uw	2263	7	of	of	IN
cord-001835-0s7ok4uw	2263	8	paramount	paramount	JJ
cord-001835-0s7ok4uw	2263	9	importance	importance	NN
cord-001835-0s7ok4uw	2263	10	for	for	IN
cord-001835-0s7ok4uw	2263	11	understanding	understand	VBG
cord-001835-0s7ok4uw	2263	12	cellular	cellular	JJ
cord-001835-0s7ok4uw	2263	13	functions	function	NNS
cord-001835-0s7ok4uw	2263	14	.	.	.
cord-001835-0s7ok4uw	2264	1	For	for	IN
cord-001835-0s7ok4uw	2264	2	instance	instance	NN
cord-001835-0s7ok4uw	2264	3	,	,	,
cord-001835-0s7ok4uw	2264	4	the	the	DT
cord-001835-0s7ok4uw	2264	5	binding	bind	VBG
cord-001835-0s7ok4uw	2264	6	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2264	7	between	between	IN
cord-001835-0s7ok4uw	2264	8	membrane	membrane	NN
cord-001835-0s7ok4uw	2264	9	receptors	receptor	NNS
cord-001835-0s7ok4uw	2264	10	and	and	CC
cord-001835-0s7ok4uw	2264	11	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2264	12	ligands	ligand	NNS
cord-001835-0s7ok4uw	2264	13	control	control	VBP
cord-001835-0s7ok4uw	2264	14	the	the	DT
cord-001835-0s7ok4uw	2264	15	speed	speed	NN
cord-001835-0s7ok4uw	2264	16	of	of	IN
cord-001835-0s7ok4uw	2264	17	signal	signal	NN
cord-001835-0s7ok4uw	2264	18	transduction	transduction	NN
cord-001835-0s7ok4uw	2264	19	after	after	IN
cord-001835-0s7ok4uw	2264	20	cells	cell	NNS
cord-001835-0s7ok4uw	2264	21	are	be	VBP
cord-001835-0s7ok4uw	2264	22	exposed	expose	VBN
cord-001835-0s7ok4uw	2264	23	to	to	IN
cord-001835-0s7ok4uw	2264	24	stimulation	stimulation	NN
cord-001835-0s7ok4uw	2264	25	.	.	.
cord-001835-0s7ok4uw	2265	1	The	the	DT
cord-001835-0s7ok4uw	2265	2	experimentally	experimentally	RB
cord-001835-0s7ok4uw	2265	3	measured	measure	VBN
cord-001835-0s7ok4uw	2265	4	association	association	NN
cord-001835-0s7ok4uw	2265	5	rates	rate	NNS
cord-001835-0s7ok4uw	2265	6	of	of	IN
cord-001835-0s7ok4uw	2265	7	protein	protein	NN
cord-001835-0s7ok4uw	2265	8	binding	bind	VBG
cord-001835-0s7ok4uw	2265	9	span	span	NN
cord-001835-0s7ok4uw	2265	10	ten	ten	CD
cord-001835-0s7ok4uw	2265	11	orders	order	NNS
cord-001835-0s7ok4uw	2265	12	of	of	IN
cord-001835-0s7ok4uw	2265	13	magnitude	magnitude	NN
cord-001835-0s7ok4uw	2265	14	,	,	,
cord-001835-0s7ok4uw	2265	15	a	a	DT
cord-001835-0s7ok4uw	2265	16	range	range	NN
cord-001835-0s7ok4uw	2265	17	that	that	WDT
cord-001835-0s7ok4uw	2265	18	was	be	VBD
cord-001835-0s7ok4uw	2265	19	divided	divide	VBN
cord-001835-0s7ok4uw	2265	20	into	into	IN
cord-001835-0s7ok4uw	2265	21	two	two	CD
cord-001835-0s7ok4uw	2265	22	regimes	regime	NNS
cord-001835-0s7ok4uw	2265	23	.	.	.
cord-001835-0s7ok4uw	2266	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2266	2	was	be	VBD
cord-001835-0s7ok4uw	2266	3	proposed	propose	VBN
cord-001835-0s7ok4uw	2266	4	that	that	IN
cord-001835-0s7ok4uw	2266	5	a	a	DT
cord-001835-0s7ok4uw	2266	6	fast	fast	JJ
cord-001835-0s7ok4uw	2266	7	association	association	NN
cord-001835-0s7ok4uw	2266	8	regime	regime	NN
cord-001835-0s7ok4uw	2266	9	is	be	VBZ
cord-001835-0s7ok4uw	2266	10	limited	limit	VBN
cord-001835-0s7ok4uw	2266	11	by	by	IN
cord-001835-0s7ok4uw	2266	12	protein	protein	NN
cord-001835-0s7ok4uw	2266	13	diffusion	diffusion	NN
cord-001835-0s7ok4uw	2266	14	,	,	,
cord-001835-0s7ok4uw	2266	15	while	while	IN
cord-001835-0s7ok4uw	2266	16	the	the	DT
cord-001835-0s7ok4uw	2266	17	other	other	JJ
cord-001835-0s7ok4uw	2266	18	side	side	NN
cord-001835-0s7ok4uw	2266	19	of	of	IN
cord-001835-0s7ok4uw	2266	20	the	the	DT
cord-001835-0s7ok4uw	2266	21	spectrum	spectrum	NN
cord-001835-0s7ok4uw	2266	22	is	be	VBZ
cord-001835-0s7ok4uw	2266	23	controlled	control	VBN
cord-001835-0s7ok4uw	2266	24	by	by	IN
cord-001835-0s7ok4uw	2266	25	conformational	conformational	JJ
cord-001835-0s7ok4uw	2266	26	changes	change	NNS
cord-001835-0s7ok4uw	2266	27	.	.	.
cord-001835-0s7ok4uw	2267	1	Consequently	consequently	RB
cord-001835-0s7ok4uw	2267	2	,	,	,
cord-001835-0s7ok4uw	2267	3	all	all	DT
cord-001835-0s7ok4uw	2267	4	previous	previous	JJ
cord-001835-0s7ok4uw	2267	5	simulation	simulation	NN
cord-001835-0s7ok4uw	2267	6	methods	method	NNS
cord-001835-0s7ok4uw	2267	7	neglected	neglect	VBD
cord-001835-0s7ok4uw	2267	8	conformational	conformational	JJ
cord-001835-0s7ok4uw	2267	9	changes	change	NNS
cord-001835-0s7ok4uw	2267	10	when	when	WRB
cord-001835-0s7ok4uw	2267	11	calculating	calculate	VBG
cord-001835-0s7ok4uw	2267	12	the	the	DT
cord-001835-0s7ok4uw	2267	13	association	association	NN
cord-001835-0s7ok4uw	2267	14	rate	rate	NN
cord-001835-0s7ok4uw	2267	15	of	of	IN
cord-001835-0s7ok4uw	2267	16	a	a	DT
cord-001835-0s7ok4uw	2267	17	diffusion	diffusion	NN
cord-001835-0s7ok4uw	2267	18	-	-	HYPH
cord-001835-0s7ok4uw	2267	19	limited	limit	VBN
cord-001835-0s7ok4uw	2267	20	regime	regime	NN
cord-001835-0s7ok4uw	2267	21	.	.	.
cord-001835-0s7ok4uw	2268	1	However	however	RB
cord-001835-0s7ok4uw	2268	2	,	,	,
cord-001835-0s7ok4uw	2268	3	the	the	DT
cord-001835-0s7ok4uw	2268	4	most	most	RBS
cord-001835-0s7ok4uw	2268	5	updated	updated	JJ
cord-001835-0s7ok4uw	2268	6	theory	theory	NN
cord-001835-0s7ok4uw	2268	7	of	of	IN
cord-001835-0s7ok4uw	2268	8	protein	protein	NN
cord-001835-0s7ok4uw	2268	9	binding	binding	NN
cord-001835-0s7ok4uw	2268	10	suggests	suggest	VBZ
cord-001835-0s7ok4uw	2268	11	that	that	IN
cord-001835-0s7ok4uw	2268	12	a	a	DT
cord-001835-0s7ok4uw	2268	13	protein	protein	NN
cord-001835-0s7ok4uw	2268	14	remains	remain	VBZ
cord-001835-0s7ok4uw	2268	15	in	in	IN
cord-001835-0s7ok4uw	2268	16	a	a	DT
cord-001835-0s7ok4uw	2268	17	pre	pre	JJ
cord-001835-0s7ok4uw	2268	18	-	-	JJ
cord-001835-0s7ok4uw	2268	19	existing	existing	JJ
cord-001835-0s7ok4uw	2268	20	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	2268	21	of	of	IN
cord-001835-0s7ok4uw	2268	22	unbound	unbound	JJ
cord-001835-0s7ok4uw	2268	23	conformations	conformation	NNS
cord-001835-0s7ok4uw	2268	24	.	.	.
cord-001835-0s7ok4uw	2269	1	Binding	binding	NN
cord-001835-0s7ok4uw	2269	2	shifts	shift	VBZ
cord-001835-0s7ok4uw	2269	3	the	the	DT
cord-001835-0s7ok4uw	2269	4	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	2269	5	toward	toward	IN
cord-001835-0s7ok4uw	2269	6	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2269	7	bound	bind	VBN
cord-001835-0s7ok4uw	2269	8	state	state	NN
cord-001835-0s7ok4uw	2269	9	.	.	.
cord-001835-0s7ok4uw	2270	1	This	this	DT
cord-001835-0s7ok4uw	2270	2	highlights	highlight	VBZ
cord-001835-0s7ok4uw	2270	3	the	the	DT
cord-001835-0s7ok4uw	2270	4	importance	importance	NN
cord-001835-0s7ok4uw	2270	5	of	of	IN
cord-001835-0s7ok4uw	2270	6	conformational	conformational	JJ
cord-001835-0s7ok4uw	2270	7	factors	factor	NNS
cord-001835-0s7ok4uw	2270	8	for	for	IN
cord-001835-0s7ok4uw	2270	9	regulating	regulate	VBG
cord-001835-0s7ok4uw	2270	10	protein	protein	NN
cord-001835-0s7ok4uw	2270	11	binding	bind	VBG
cord-001835-0s7ok4uw	2270	12	.	.	.
cord-001835-0s7ok4uw	2271	1	Enlightened	enlighten	VBN
cord-001835-0s7ok4uw	2271	2	by	by	IN
cord-001835-0s7ok4uw	2271	3	this	this	DT
cord-001835-0s7ok4uw	2271	4	conformational	conformational	JJ
cord-001835-0s7ok4uw	2271	5	selection	selection	NN
cord-001835-0s7ok4uw	2271	6	model	model	NN
cord-001835-0s7ok4uw	2271	7	,	,	,
cord-001835-0s7ok4uw	2271	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	2271	9	hypothesize	hypothesize	VBP
cord-001835-0s7ok4uw	2271	10	that	that	IN
cord-001835-0s7ok4uw	2271	11	the	the	DT
cord-001835-0s7ok4uw	2271	12	conformational	conformational	JJ
cord-001835-0s7ok4uw	2271	13	flexibility	flexibility	NN
cord-001835-0s7ok4uw	2271	14	of	of	IN
cord-001835-0s7ok4uw	2271	15	protein	protein	NN
cord-001835-0s7ok4uw	2271	16	structures	structure	NNS
cord-001835-0s7ok4uw	2271	17	regulates	regulate	VBZ
cord-001835-0s7ok4uw	2271	18	association	association	NN
cord-001835-0s7ok4uw	2271	19	more	more	RBR
cord-001835-0s7ok4uw	2271	20	widely	widely	RB
cord-001835-0s7ok4uw	2271	21	than	than	IN
cord-001835-0s7ok4uw	2271	22	previously	previously	RB
cord-001835-0s7ok4uw	2271	23	anticipated	anticipate	VBN
cord-001835-0s7ok4uw	2271	24	.	.	.
cord-001835-0s7ok4uw	2272	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2272	2	develop	develop	VBP
cord-001835-0s7ok4uw	2272	3	a	a	DT
cord-001835-0s7ok4uw	2272	4	new	new	JJ
cord-001835-0s7ok4uw	2272	5	coarse	coarse	RB
cord-001835-0s7ok4uw	2272	6	-	-	HYPH
cord-001835-0s7ok4uw	2272	7	grained	grained	JJ
cord-001835-0s7ok4uw	2272	8	model	model	NN
cord-001835-0s7ok4uw	2272	9	to	to	TO
cord-001835-0s7ok4uw	2272	10	simulate	simulate	VB
cord-001835-0s7ok4uw	2272	11	the	the	DT
cord-001835-0s7ok4uw	2272	12	process	process	NN
cord-001835-0s7ok4uw	2272	13	of	of	IN
cord-001835-0s7ok4uw	2272	14	protein	protein	NNP
cord-001835-0s7ok4uw	2272	15	association	association	NNP
cord-001835-0s7ok4uw	2272	16	via	via	IN
cord-001835-0s7ok4uw	2272	17	the	the	DT
cord-001835-0s7ok4uw	2272	18	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	2272	19	Monte	Monte	NNP
cord-001835-0s7ok4uw	2272	20	Carlo	Carlo	NNP
cord-001835-0s7ok4uw	2272	21	(	(	-LRB-
cord-001835-0s7ok4uw	2272	22	KMC	KMC	NNP
cord-001835-0s7ok4uw	2272	23	)	)	-RRB-
cord-001835-0s7ok4uw	2272	24	algorithm	algorithm	NN
cord-001835-0s7ok4uw	2272	25	.	.	.
cord-001835-0s7ok4uw	2273	1	Each	each	DT
cord-001835-0s7ok4uw	2273	2	residue	residue	NN
cord-001835-0s7ok4uw	2273	3	in	in	IN
cord-001835-0s7ok4uw	2273	4	this	this	DT
cord-001835-0s7ok4uw	2273	5	model	model	NN
cord-001835-0s7ok4uw	2273	6	is	be	VBZ
cord-001835-0s7ok4uw	2273	7	represented	represent	VBN
cord-001835-0s7ok4uw	2273	8	by	by	IN
cord-001835-0s7ok4uw	2273	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2273	10	Ca	Ca	NNP
cord-001835-0s7ok4uw	2273	11	atom	atom	NN
cord-001835-0s7ok4uw	2273	12	and	and	CC
cord-001835-0s7ok4uw	2273	13	a	a	DT
cord-001835-0s7ok4uw	2273	14	side	side	NN
cord-001835-0s7ok4uw	2273	15	-	-	HYPH
cord-001835-0s7ok4uw	2273	16	chain	chain	NN
cord-001835-0s7ok4uw	2273	17	functional	functional	JJ
cord-001835-0s7ok4uw	2273	18	site	site	NN
cord-001835-0s7ok4uw	2273	19	.	.	.
cord-001835-0s7ok4uw	2274	1	A	a	DT
cord-001835-0s7ok4uw	2274	2	simple	simple	JJ
cord-001835-0s7ok4uw	2274	3	physically	physically	RB
cord-001835-0s7ok4uw	2274	4	based	base	VBN
cord-001835-0s7ok4uw	2274	5	potential	potential	NN
cord-001835-0s7ok4uw	2274	6	is	be	VBZ
cord-001835-0s7ok4uw	2274	7	used	use	VBN
cord-001835-0s7ok4uw	2274	8	to	to	TO
cord-001835-0s7ok4uw	2274	9	guide	guide	VB
cord-001835-0s7ok4uw	2274	10	the	the	DT
cord-001835-0s7ok4uw	2274	11	relative	relative	JJ
cord-001835-0s7ok4uw	2274	12	diffusion	diffusion	NN
cord-001835-0s7ok4uw	2274	13	of	of	IN
cord-001835-0s7ok4uw	2274	14	two	two	CD
cord-001835-0s7ok4uw	2274	15	interacting	interact	VBG
cord-001835-0s7ok4uw	2274	16	proteins	protein	NNS
cord-001835-0s7ok4uw	2274	17	.	.	.
cord-001835-0s7ok4uw	2275	1	Given	give	VBN
cord-001835-0s7ok4uw	2275	2	the	the	DT
cord-001835-0s7ok4uw	2275	3	size	size	NN
cord-001835-0s7ok4uw	2275	4	of	of	IN
cord-001835-0s7ok4uw	2275	5	the	the	DT
cord-001835-0s7ok4uw	2275	6	simulation	simulation	NN
cord-001835-0s7ok4uw	2275	7	box	box	NN
cord-001835-0s7ok4uw	2275	8	and	and	CC
cord-001835-0s7ok4uw	2275	9	the	the	DT
cord-001835-0s7ok4uw	2275	10	length	length	NN
cord-001835-0s7ok4uw	2275	11	of	of	IN
cord-001835-0s7ok4uw	2275	12	the	the	DT
cord-001835-0s7ok4uw	2275	13	simulation	simulation	NN
cord-001835-0s7ok4uw	2275	14	,	,	,
cord-001835-0s7ok4uw	2275	15	the	the	DT
cord-001835-0s7ok4uw	2275	16	association	association	NN
cord-001835-0s7ok4uw	2275	17	rate	rate	NN
cord-001835-0s7ok4uw	2275	18	constant	constant	NN
cord-001835-0s7ok4uw	2275	19	can	can	MD
cord-001835-0s7ok4uw	2275	20	be	be	VB
cord-001835-0s7ok4uw	2275	21	derived	derive	VBN
cord-001835-0s7ok4uw	2275	22	by	by	IN
cord-001835-0s7ok4uw	2275	23	counting	count	VBG
cord-001835-0s7ok4uw	2275	24	the	the	DT
cord-001835-0s7ok4uw	2275	25	frequency	frequency	NN
cord-001835-0s7ok4uw	2275	26	of	of	IN
cord-001835-0s7ok4uw	2275	27	dimerization	dimerization	NN
cord-001835-0s7ok4uw	2275	28	among	among	IN
cord-001835-0s7ok4uw	2275	29	a	a	DT
cord-001835-0s7ok4uw	2275	30	large	large	JJ
cord-001835-0s7ok4uw	2275	31	number	number	NN
cord-001835-0s7ok4uw	2275	32	of	of	IN
cord-001835-0s7ok4uw	2275	33	simulation	simulation	NN
cord-001835-0s7ok4uw	2275	34	trajectories	trajectory	NNS
cord-001835-0s7ok4uw	2275	35	.	.	.
cord-001835-0s7ok4uw	2276	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2276	2	further	further	RB
cord-001835-0s7ok4uw	2276	3	designed	design	VBD
cord-001835-0s7ok4uw	2276	4	a	a	DT
cord-001835-0s7ok4uw	2276	5	prediction	prediction	NN
cord-001835-0s7ok4uw	2276	6	strategy	strategy	NN
cord-001835-0s7ok4uw	2276	7	that	that	WDT
cord-001835-0s7ok4uw	2276	8	accounts	account	VBZ
cord-001835-0s7ok4uw	2276	9	for	for	IN
cord-001835-0s7ok4uw	2276	10	both	both	CC
cord-001835-0s7ok4uw	2276	11	the	the	DT
cord-001835-0s7ok4uw	2276	12	conformational	conformational	JJ
cord-001835-0s7ok4uw	2276	13	and	and	CC
cord-001835-0s7ok4uw	2276	14	energetic	energetic	JJ
cord-001835-0s7ok4uw	2276	15	factors	factor	NNS
cord-001835-0s7ok4uw	2276	16	of	of	IN
cord-001835-0s7ok4uw	2276	17	binding	bind	VBG
cord-001835-0s7ok4uw	2276	18	.	.	.
cord-001835-0s7ok4uw	2277	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2277	2	method	method	NN
cord-001835-0s7ok4uw	2277	3	is	be	VBZ
cord-001835-0s7ok4uw	2277	4	able	able	JJ
cord-001835-0s7ok4uw	2277	5	to	to	TO
cord-001835-0s7ok4uw	2277	6	predict	predict	VB
cord-001835-0s7ok4uw	2277	7	rates	rate	NNS
cord-001835-0s7ok4uw	2277	8	of	of	IN
cord-001835-0s7ok4uw	2277	9	protein	protein	NNP
cord-001835-0s7ok4uw	2277	10	association	association	NNP
cord-001835-0s7ok4uw	2277	11	that	that	WDT
cord-001835-0s7ok4uw	2277	12	are	be	VBP
cord-001835-0s7ok4uw	2277	13	highly	highly	RB
cord-001835-0s7ok4uw	2277	14	correlated	correlate	VBN
cord-001835-0s7ok4uw	2277	15	with	with	IN
cord-001835-0s7ok4uw	2277	16	experimentally	experimentally	RB
cord-001835-0s7ok4uw	2277	17	measured	measure	VBN
cord-001835-0s7ok4uw	2277	18	values	value	NNS
cord-001835-0s7ok4uw	2277	19	.	.	.
cord-001835-0s7ok4uw	2278	1	Due	due	IN
cord-001835-0s7ok4uw	2278	2	to	to	IN
cord-001835-0s7ok4uw	2278	3	the	the	DT
cord-001835-0s7ok4uw	2278	4	coarse	coarse	RB
cord-001835-0s7ok4uw	2278	5	-	-	HYPH
cord-001835-0s7ok4uw	2278	6	grained	grained	JJ
cord-001835-0s7ok4uw	2278	7	feature	feature	NN
cord-001835-0s7ok4uw	2278	8	,	,	,
cord-001835-0s7ok4uw	2278	9	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2278	10	model	model	NN
cord-001835-0s7ok4uw	2278	11	was	be	VBD
cord-001835-0s7ok4uw	2278	12	further	further	RB
cord-001835-0s7ok4uw	2278	13	applied	apply	VBN
cord-001835-0s7ok4uw	2278	14	to	to	IN
cord-001835-0s7ok4uw	2278	15	several	several	JJ
cord-001835-0s7ok4uw	2278	16	special	special	JJ
cord-001835-0s7ok4uw	2278	17	cases	case	NNS
cord-001835-0s7ok4uw	2278	18	of	of	IN
cord-001835-0s7ok4uw	2278	19	protein	protein	NNP
cord-001835-0s7ok4uw	2278	20	association	association	NNP
cord-001835-0s7ok4uw	2278	21	.	.	.
cord-001835-0s7ok4uw	2279	1	In	in	IN
cord-001835-0s7ok4uw	2279	2	one	one	CD
cord-001835-0s7ok4uw	2279	3	example	example	NN
cord-001835-0s7ok4uw	2279	4	,	,	,
cord-001835-0s7ok4uw	2279	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2279	6	studied	study	VBD
cord-001835-0s7ok4uw	2279	7	the	the	DT
cord-001835-0s7ok4uw	2279	8	binding	bind	VBG
cord-001835-0s7ok4uw	2279	9	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2279	10	of	of	IN
cord-001835-0s7ok4uw	2279	11	proteins	protein	NNS
cord-001835-0s7ok4uw	2279	12	with	with	IN
cord-001835-0s7ok4uw	2279	13	flexible	flexible	JJ
cord-001835-0s7ok4uw	2279	14	linkers	linker	NNS
cord-001835-0s7ok4uw	2279	15	.	.	.
cord-001835-0s7ok4uw	2280	1	The	the	DT
cord-001835-0s7ok4uw	2280	2	interaction	interaction	NN
cord-001835-0s7ok4uw	2280	3	between	between	IN
cord-001835-0s7ok4uw	2280	4	thrombin	thrombin	NN
cord-001835-0s7ok4uw	2280	5	and	and	CC
cord-001835-0s7ok4uw	2280	6	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2280	7	functional	functional	JJ
cord-001835-0s7ok4uw	2280	8	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	2280	9	,	,	,
cord-001835-0s7ok4uw	2280	10	rhodniin	rhodniin	NNP
cord-001835-0s7ok4uw	2280	11	,	,	,
cord-001835-0s7ok4uw	2280	12	was	be	VBD
cord-001835-0s7ok4uw	2280	13	used	use	VBN
cord-001835-0s7ok4uw	2280	14	as	as	IN
cord-001835-0s7ok4uw	2280	15	a	a	DT
cord-001835-0s7ok4uw	2280	16	testing	testing	NN
cord-001835-0s7ok4uw	2280	17	system	system	NN
cord-001835-0s7ok4uw	2280	18	.	.	.
cord-001835-0s7ok4uw	2281	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2281	2	captured	capture	VBD
cord-001835-0s7ok4uw	2281	3	the	the	DT
cord-001835-0s7ok4uw	2281	4	conformational	conformational	JJ
cord-001835-0s7ok4uw	2281	5	changes	change	NNS
cord-001835-0s7ok4uw	2281	6	of	of	IN
cord-001835-0s7ok4uw	2281	7	flexible	flexible	JJ
cord-001835-0s7ok4uw	2281	8	linkers	linker	NNS
cord-001835-0s7ok4uw	2281	9	from	from	IN
cord-001835-0s7ok4uw	2281	10	the	the	DT
cord-001835-0s7ok4uw	2281	11	all	all	DT
cord-001835-0s7ok4uw	2281	12	-	-	HYPH
cord-001835-0s7ok4uw	2281	13	atom	atom	NN
cord-001835-0s7ok4uw	2281	14	molecular	molecular	JJ
cord-001835-0s7ok4uw	2281	15	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2281	16	simulations	simulation	NNS
cord-001835-0s7ok4uw	2281	17	.	.	.
cord-001835-0s7ok4uw	2282	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2282	2	found	find	VBD
cord-001835-0s7ok4uw	2282	3	that	that	IN
cord-001835-0s7ok4uw	2282	4	the	the	DT
cord-001835-0s7ok4uw	2282	5	association	association	NN
cord-001835-0s7ok4uw	2282	6	with	with	IN
cord-001835-0s7ok4uw	2282	7	full	full	JJ
cord-001835-0s7ok4uw	2282	8	-	-	HYPH
cord-001835-0s7ok4uw	2282	9	length	length	NN
cord-001835-0s7ok4uw	2282	10	flexible	flexible	JJ
cord-001835-0s7ok4uw	2282	11	rhodniin	rhodniin	NN
cord-001835-0s7ok4uw	2282	12	was	be	VBD
cord-001835-0s7ok4uw	2282	13	faster	fast	JJR
cord-001835-0s7ok4uw	2282	14	than	than	IN
cord-001835-0s7ok4uw	2282	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2282	16	two	two	CD
cord-001835-0s7ok4uw	2282	17	individual	individual	JJ
cord-001835-0s7ok4uw	2282	18	domains	domain	NNS
cord-001835-0s7ok4uw	2282	19	and	and	CC
cord-001835-0s7ok4uw	2282	20	that	that	IN
cord-001835-0s7ok4uw	2282	21	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2282	22	dissociation	dissociation	NN
cord-001835-0s7ok4uw	2282	23	was	be	VBD
cord-001835-0s7ok4uw	2282	24	more	more	RBR
cord-001835-0s7ok4uw	2282	25	difficult	difficult	JJ
cord-001835-0s7ok4uw	2282	26	,	,	,
cord-001835-0s7ok4uw	2282	27	supporting	support	VBG
cord-001835-0s7ok4uw	2282	28	a	a	DT
cord-001835-0s7ok4uw	2282	29	"	"	``
cord-001835-0s7ok4uw	2282	30	flycasting	flycasting	NN
cord-001835-0s7ok4uw	2282	31	"	"	''
cord-001835-0s7ok4uw	2282	32	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2282	33	in	in	IN
cord-001835-0s7ok4uw	2282	34	which	which	WDT
cord-001835-0s7ok4uw	2282	35	partial	partial	JJ
cord-001835-0s7ok4uw	2282	36	structures	structure	NNS
cord-001835-0s7ok4uw	2282	37	of	of	IN
cord-001835-0s7ok4uw	2282	38	an	an	DT
cord-001835-0s7ok4uw	2282	39	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	2282	40	disordered	disordered	JJ
cord-001835-0s7ok4uw	2282	41	protein	protein	NN
cord-001835-0s7ok4uw	2282	42	(	(	-LRB-
cord-001835-0s7ok4uw	2282	43	IDP	IDP	NNP
cord-001835-0s7ok4uw	2282	44	)	)	-RRB-
cord-001835-0s7ok4uw	2282	45	dock	dock	NN
cord-001835-0s7ok4uw	2282	46	to	to	IN
cord-001835-0s7ok4uw	2282	47	the	the	DT
cord-001835-0s7ok4uw	2282	48	target	target	NN
cord-001835-0s7ok4uw	2282	49	first	first	RB
cord-001835-0s7ok4uw	2282	50	,	,	,
cord-001835-0s7ok4uw	2282	51	while	while	IN
cord-001835-0s7ok4uw	2282	52	the	the	DT
cord-001835-0s7ok4uw	2282	53	remaining	remain	VBG
cord-001835-0s7ok4uw	2282	54	segments	segment	NNS
cord-001835-0s7ok4uw	2282	55	undergo	undergo	VBP
cord-001835-0s7ok4uw	2282	56	conformational	conformational	JJ
cord-001835-0s7ok4uw	2282	57	searches	search	NNS
cord-001835-0s7ok4uw	2282	58	and	and	CC
cord-001835-0s7ok4uw	2282	59	sequentially	sequentially	RB
cord-001835-0s7ok4uw	2282	60	coalesce	coalesce	VB
cord-001835-0s7ok4uw	2282	61	around	around	IN
cord-001835-0s7ok4uw	2282	62	the	the	DT
cord-001835-0s7ok4uw	2282	63	target	target	NN
cord-001835-0s7ok4uw	2282	64	.	.	.
cord-001835-0s7ok4uw	2283	1	In	in	IN
cord-001835-0s7ok4uw	2283	2	another	another	DT
cord-001835-0s7ok4uw	2283	3	example	example	NN
cord-001835-0s7ok4uw	2283	4	,	,	,
cord-001835-0s7ok4uw	2283	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2283	6	studied	study	VBD
cord-001835-0s7ok4uw	2283	7	the	the	DT
cord-001835-0s7ok4uw	2283	8	binding	bind	VBG
cord-001835-0s7ok4uw	2283	9	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2283	10	of	of	IN
cord-001835-0s7ok4uw	2283	11	membrane	membrane	NN
cord-001835-0s7ok4uw	2283	12	receptors	receptor	NNS
cord-001835-0s7ok4uw	2283	13	from	from	IN
cord-001835-0s7ok4uw	2283	14	cellular	cellular	JJ
cord-001835-0s7ok4uw	2283	15	interfaces	interface	NNS
cord-001835-0s7ok4uw	2283	16	.	.	.
cord-001835-0s7ok4uw	2284	1	The	the	DT
cord-001835-0s7ok4uw	2284	2	interaction	interaction	NN
cord-001835-0s7ok4uw	2284	3	between	between	IN
cord-001835-0s7ok4uw	2284	4	membrane	membrane	NN
cord-001835-0s7ok4uw	2284	5	proteins	protein	NNS
cord-001835-0s7ok4uw	2284	6	CD2	CD2	NNP
cord-001835-0s7ok4uw	2284	7	and	and	CC
cord-001835-0s7ok4uw	2284	8	CD58	CD58	NNP
cord-001835-0s7ok4uw	2284	9	,	,	,
cord-001835-0s7ok4uw	2284	10	cell	cell	NN
cord-001835-0s7ok4uw	2284	11	adhesion	adhesion	NN
cord-001835-0s7ok4uw	2284	12	molecules	molecule	NNS
cord-001835-0s7ok4uw	2284	13	known	know	VBN
cord-001835-0s7ok4uw	2284	14	to	to	TO
cord-001835-0s7ok4uw	2284	15	mediate	mediate	VB
cord-001835-0s7ok4uw	2284	16	the	the	DT
cord-001835-0s7ok4uw	2284	17	activation	activation	NN
cord-001835-0s7ok4uw	2284	18	of	of	IN
cord-001835-0s7ok4uw	2284	19	T	T	NNP
cord-001835-0s7ok4uw	2284	20	cells	cell	NNS
cord-001835-0s7ok4uw	2284	21	and	and	CC
cord-001835-0s7ok4uw	2284	22	natural	natural	JJ
cord-001835-0s7ok4uw	2284	23	killer	killer	NN
cord-001835-0s7ok4uw	2284	24	cells	cell	NNS
cord-001835-0s7ok4uw	2284	25	,	,	,
cord-001835-0s7ok4uw	2284	26	was	be	VBD
cord-001835-0s7ok4uw	2284	27	used	use	VBN
cord-001835-0s7ok4uw	2284	28	as	as	IN
cord-001835-0s7ok4uw	2284	29	a	a	DT
cord-001835-0s7ok4uw	2284	30	testing	testing	NN
cord-001835-0s7ok4uw	2284	31	system	system	NN
cord-001835-0s7ok4uw	2284	32	.	.	.
cord-001835-0s7ok4uw	2285	1	The	the	DT
cord-001835-0s7ok4uw	2285	2	diffusive	diffusive	JJ
cord-001835-0s7ok4uw	2285	3	properties	property	NNS
cord-001835-0s7ok4uw	2285	4	of	of	IN
cord-001835-0s7ok4uw	2285	5	these	these	DT
cord-001835-0s7ok4uw	2285	6	proteins	protein	NNS
cord-001835-0s7ok4uw	2285	7	on	on	IN
cord-001835-0s7ok4uw	2285	8	lipid	lipid	NN
cord-001835-0s7ok4uw	2285	9	bilayer	bilayer	NN
cord-001835-0s7ok4uw	2285	10	were	be	VBD
cord-001835-0s7ok4uw	2285	11	captured	capture	VBN
cord-001835-0s7ok4uw	2285	12	from	from	IN
cord-001835-0s7ok4uw	2285	13	all	all	DT
cord-001835-0s7ok4uw	2285	14	-	-	HYPH
cord-001835-0s7ok4uw	2285	15	atom	atom	NN
cord-001835-0s7ok4uw	2285	16	molecular	molecular	JJ
cord-001835-0s7ok4uw	2285	17	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2285	18	simulations	simulation	NNS
cord-001835-0s7ok4uw	2285	19	.	.	.
cord-001835-0s7ok4uw	2286	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2286	2	showed	show	VBD
cord-001835-0s7ok4uw	2286	3	that	that	IN
cord-001835-0s7ok4uw	2286	4	both	both	DT
cord-001835-0s7ok4uw	2286	5	3D	3D	NNP
cord-001835-0s7ok4uw	2286	6	and	and	CC
cord-001835-0s7ok4uw	2286	7	2D	2D	NNP
cord-001835-0s7ok4uw	2286	8	association	association	NNP
cord-001835-0s7ok4uw	2286	9	rates	rate	NNS
cord-001835-0s7ok4uw	2286	10	could	could	MD
cord-001835-0s7ok4uw	2286	11	be	be	VB
cord-001835-0s7ok4uw	2286	12	simulated	simulate	VBN
cord-001835-0s7ok4uw	2286	13	quantitatively	quantitatively	RB
cord-001835-0s7ok4uw	2286	14	with	with	IN
cord-001835-0s7ok4uw	2286	15	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2286	16	method	method	NN
cord-001835-0s7ok4uw	2286	17	.	.	.
cord-001835-0s7ok4uw	2287	1	The	the	DT
cord-001835-0s7ok4uw	2287	2	calculated	calculate	VBN
cord-001835-0s7ok4uw	2287	3	values	value	NNS
cord-001835-0s7ok4uw	2287	4	were	be	VBD
cord-001835-0s7ok4uw	2287	5	close	close	JJ
cord-001835-0s7ok4uw	2287	6	to	to	IN
cord-001835-0s7ok4uw	2287	7	the	the	DT
cord-001835-0s7ok4uw	2287	8	experimental	experimental	JJ
cord-001835-0s7ok4uw	2287	9	measurements	measurement	NNS
cord-001835-0s7ok4uw	2287	10	.	.	.
cord-001835-0s7ok4uw	2288	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2288	2	also	also	RB
cord-001835-0s7ok4uw	2288	3	provided	provide	VBD
cord-001835-0s7ok4uw	2288	4	detailed	detailed	JJ
cord-001835-0s7ok4uw	2288	5	analysis	analysis	NN
cord-001835-0s7ok4uw	2288	6	of	of	IN
cord-001835-0s7ok4uw	2288	7	how	how	WRB
cord-001835-0s7ok4uw	2288	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	2288	9	diffusions	diffusion	NNS
cord-001835-0s7ok4uw	2288	10	and	and	CC
cord-001835-0s7ok4uw	2288	11	membrane	membrane	NN
cord-001835-0s7ok4uw	2288	12	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	2288	13	affected	affect	VBD
cord-001835-0s7ok4uw	2288	14	2D	2D	NNP
cord-001835-0s7ok4uw	2288	15	association	association	NNP
cord-001835-0s7ok4uw	2288	16	.	.	.
cord-001835-0s7ok4uw	2289	1	PF-023	pf-023	LS
cord-001835-0s7ok4uw	2289	2	(	(	-LRB-
cord-001835-0s7ok4uw	2289	3	Un)structure	un)structure	CD
cord-001835-0s7ok4uw	2289	4	-	-	HYPH
cord-001835-0s7ok4uw	2289	5	function	function	NN
cord-001835-0s7ok4uw	2289	6	relationships	relationship	NNS
cord-001835-0s7ok4uw	2289	7	on	on	IN
cord-001835-0s7ok4uw	2289	8	the	the	DT
cord-001835-0s7ok4uw	2289	9	UreG	UreG	NNP
cord-001835-0s7ok4uw	2289	10	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2289	11	in	in	IN
cord-001835-0s7ok4uw	2289	12	the	the	DT
cord-001835-0s7ok4uw	2289	13	nickel	nickel	NN
cord-001835-0s7ok4uw	2289	14	-	-	HYPH
cord-001835-0s7ok4uw	2289	15	dependent	dependent	JJ
cord-001835-0s7ok4uw	2289	16	urease	urease	NN
cord-001835-0s7ok4uw	2289	17	system	system	NN
cord-001835-0s7ok4uw	2289	18	Barbara	Barbara	NNP
cord-001835-0s7ok4uw	2289	19	Zambelli	Zambelli	NNP
cord-001835-0s7ok4uw	2289	20	1	1	CD
cord-001835-0s7ok4uw	2289	21	,	,	,
cord-001835-0s7ok4uw	2289	22	Francesco	Francesco	NNP
cord-001835-0s7ok4uw	2289	23	Musiani	Musiani	NNP
cord-001835-0s7ok4uw	2289	24	1	1	CD
cord-001835-0s7ok4uw	2289	25	,	,	,
cord-001835-0s7ok4uw	2289	26	Stefano	Stefano	NNP
cord-001835-0s7ok4uw	2289	27	Ciurli	Ciurli	NNP
cord-001835-0s7ok4uw	2289	28	1	1	CD
cord-001835-0s7ok4uw	2289	29	1	1	CD
cord-001835-0s7ok4uw	2289	30	Urease	Urease	NNP
cord-001835-0s7ok4uw	2289	31	is	be	VBZ
cord-001835-0s7ok4uw	2289	32	an	an	DT
cord-001835-0s7ok4uw	2289	33	essential	essential	JJ
cord-001835-0s7ok4uw	2289	34	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2289	35	for	for	IN
cord-001835-0s7ok4uw	2289	36	many	many	JJ
cord-001835-0s7ok4uw	2289	37	pathogens	pathogen	NNS
cord-001835-0s7ok4uw	2289	38	and	and	CC
cord-001835-0s7ok4uw	2289	39	soil	soil	NN
cord-001835-0s7ok4uw	2289	40	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	2289	41	.	.	.
cord-001835-0s7ok4uw	2290	1	Its	-PRON-	PRP$
cord-001835-0s7ok4uw	2290	2	activity	activity	NN
cord-001835-0s7ok4uw	2290	3	relies	rely	VBZ
cord-001835-0s7ok4uw	2290	4	on	on	IN
cord-001835-0s7ok4uw	2290	5	the	the	DT
cord-001835-0s7ok4uw	2290	6	presence	presence	NN
cord-001835-0s7ok4uw	2290	7	of	of	IN
cord-001835-0s7ok4uw	2290	8	nickel	nickel	NN
cord-001835-0s7ok4uw	2290	9	in	in	IN
cord-001835-0s7ok4uw	2290	10	the	the	DT
cord-001835-0s7ok4uw	2290	11	active	active	JJ
cord-001835-0s7ok4uw	2290	12	site	site	NN
cord-001835-0s7ok4uw	2290	13	(	(	-LRB-
cord-001835-0s7ok4uw	2290	14	1	1	CD
cord-001835-0s7ok4uw	2290	15	)	)	-RRB-
cord-001835-0s7ok4uw	2290	16	.	.	.
cord-001835-0s7ok4uw	2291	1	The	the	DT
cord-001835-0s7ok4uw	2291	2	incorporation	incorporation	NN
cord-001835-0s7ok4uw	2291	3	of	of	IN
cord-001835-0s7ok4uw	2291	4	this	this	DT
cord-001835-0s7ok4uw	2291	5	metal	metal	NN
cord-001835-0s7ok4uw	2291	6	ion	ion	NN
cord-001835-0s7ok4uw	2291	7	into	into	IN
cord-001835-0s7ok4uw	2291	8	the	the	DT
cord-001835-0s7ok4uw	2291	9	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2291	10	requires	require	VBZ
cord-001835-0s7ok4uw	2291	11	the	the	DT
cord-001835-0s7ok4uw	2291	12	formation	formation	NN
cord-001835-0s7ok4uw	2291	13	of	of	IN
cord-001835-0s7ok4uw	2291	14	a	a	DT
cord-001835-0s7ok4uw	2291	15	supra	supra	JJ
cord-001835-0s7ok4uw	2291	16	-	-	HYPH
cord-001835-0s7ok4uw	2291	17	molecular	molecular	JJ
cord-001835-0s7ok4uw	2291	18	chaperone	chaperone	NN
cord-001835-0s7ok4uw	2291	19	involving	involve	VBG
cord-001835-0s7ok4uw	2291	20	four	four	CD
cord-001835-0s7ok4uw	2291	21	accessory	accessory	NN
cord-001835-0s7ok4uw	2291	22	proteins	protein	NNS
cord-001835-0s7ok4uw	2291	23	,	,	,
cord-001835-0s7ok4uw	2291	24	named	name	VBN
cord-001835-0s7ok4uw	2291	25	UreD	UreD	NNP
cord-001835-0s7ok4uw	2291	26	,	,	,
cord-001835-0s7ok4uw	2291	27	UreF	UreF	NNP
cord-001835-0s7ok4uw	2291	28	,	,	,
cord-001835-0s7ok4uw	2291	29	UreG	UreG	NNP
cord-001835-0s7ok4uw	2291	30	and	and	CC
cord-001835-0s7ok4uw	2291	31	UreE.	UreE.	NNP
cord-001835-0s7ok4uw	2292	1	UreE	UreE	NNP
cord-001835-0s7ok4uw	2292	2	is	be	VBZ
cord-001835-0s7ok4uw	2292	3	a	a	DT
cord-001835-0s7ok4uw	2292	4	metallo	metallo	NN
cord-001835-0s7ok4uw	2292	5	-	-	HYPH
cord-001835-0s7ok4uw	2292	6	chaperone	chaperone	NN
cord-001835-0s7ok4uw	2292	7	involved	involve	VBN
cord-001835-0s7ok4uw	2292	8	in	in	IN
cord-001835-0s7ok4uw	2292	9	nickel	nickel	NN
cord-001835-0s7ok4uw	2292	10	binding	binding	NN
cord-001835-0s7ok4uw	2292	11	and	and	CC
cord-001835-0s7ok4uw	2292	12	delivery	delivery	NN
cord-001835-0s7ok4uw	2292	13	into	into	IN
cord-001835-0s7ok4uw	2292	14	the	the	DT
cord-001835-0s7ok4uw	2292	15	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2292	16	active	active	JJ
cord-001835-0s7ok4uw	2292	17	site	site	NN
cord-001835-0s7ok4uw	2292	18	.	.	.
cord-001835-0s7ok4uw	2293	1	UreG	UreG	NNP
cord-001835-0s7ok4uw	2293	2	is	be	VBZ
cord-001835-0s7ok4uw	2293	3	a	a	DT
cord-001835-0s7ok4uw	2293	4	GTPase	GTPase	NNP
cord-001835-0s7ok4uw	2293	5	essential	essential	JJ
cord-001835-0s7ok4uw	2293	6	for	for	IN
cord-001835-0s7ok4uw	2293	7	providing	provide	VBG
cord-001835-0s7ok4uw	2293	8	energy	energy	NN
cord-001835-0s7ok4uw	2293	9	to	to	IN
cord-001835-0s7ok4uw	2293	10	the	the	DT
cord-001835-0s7ok4uw	2293	11	process	process	NN
cord-001835-0s7ok4uw	2293	12	of	of	IN
cord-001835-0s7ok4uw	2293	13	nickel	nickel	NN
cord-001835-0s7ok4uw	2293	14	site	site	NN
cord-001835-0s7ok4uw	2293	15	assembly	assembly	NN
cord-001835-0s7ok4uw	2293	16	.	.	.
cord-001835-0s7ok4uw	2294	1	UreF	UreF	NNP
cord-001835-0s7ok4uw	2294	2	and	and	CC
cord-001835-0s7ok4uw	2294	3	UreD	UreD	NNP
cord-001835-0s7ok4uw	2294	4	form	form	VB
cord-001835-0s7ok4uw	2294	5	a	a	DT
cord-001835-0s7ok4uw	2294	6	complex	complex	NN
cord-001835-0s7ok4uw	2294	7	that	that	WDT
cord-001835-0s7ok4uw	2294	8	regulates	regulate	VBZ
cord-001835-0s7ok4uw	2294	9	the	the	DT
cord-001835-0s7ok4uw	2294	10	GTPase	GTPase	NNP
cord-001835-0s7ok4uw	2294	11	activity	activity	NN
cord-001835-0s7ok4uw	2294	12	of	of	IN
cord-001835-0s7ok4uw	2294	13	UreG.	UreG.	NNP
cord-001835-0s7ok4uw	2295	1	The	the	DT
cord-001835-0s7ok4uw	2295	2	present	present	JJ
cord-001835-0s7ok4uw	2295	3	work	work	NN
cord-001835-0s7ok4uw	2295	4	focuses	focus	VBZ
cord-001835-0s7ok4uw	2295	5	on	on	IN
cord-001835-0s7ok4uw	2295	6	UreG	UreG	NNP
cord-001835-0s7ok4uw	2295	7	,	,	,
cord-001835-0s7ok4uw	2295	8	which	which	WDT
cord-001835-0s7ok4uw	2295	9	exists	exist	VBZ
cord-001835-0s7ok4uw	2295	10	in	in	IN
cord-001835-0s7ok4uw	2295	11	solution	solution	NN
cord-001835-0s7ok4uw	2295	12	as	as	IN
cord-001835-0s7ok4uw	2295	13	an	an	DT
cord-001835-0s7ok4uw	2295	14	ensemble	ensemble	NN
cord-001835-0s7ok4uw	2295	15	of	of	IN
cord-001835-0s7ok4uw	2295	16	inter	inter	JJ
cord-001835-0s7ok4uw	2295	17	-	-	JJ
cord-001835-0s7ok4uw	2295	18	converting	converting	JJ
cord-001835-0s7ok4uw	2295	19	conformations	conformation	NNS
cord-001835-0s7ok4uw	2295	20	(	(	-LRB-
cord-001835-0s7ok4uw	2295	21	2	2	CD
cord-001835-0s7ok4uw	2295	22	)	)	-RRB-
cord-001835-0s7ok4uw	2295	23	.	.	.
cord-001835-0s7ok4uw	2296	1	This	this	DT
cord-001835-0s7ok4uw	2296	2	observation	observation	NN
cord-001835-0s7ok4uw	2296	3	made	make	VBD
cord-001835-0s7ok4uw	2296	4	this	this	DT
cord-001835-0s7ok4uw	2296	5	protein	protein	NN
cord-001835-0s7ok4uw	2296	6	the	the	DT
cord-001835-0s7ok4uw	2296	7	firstly	firstly	RB
cord-001835-0s7ok4uw	2296	8	discovered	discover	VBN
cord-001835-0s7ok4uw	2296	9	natural	natural	JJ
cord-001835-0s7ok4uw	2296	10	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2296	11	with	with	IN
cord-001835-0s7ok4uw	2296	12	an	an	DT
cord-001835-0s7ok4uw	2296	13	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2296	14	disordered	disordered	JJ
cord-001835-0s7ok4uw	2296	15	behavior	behavior	NN
cord-001835-0s7ok4uw	2296	16	,	,	,
cord-001835-0s7ok4uw	2296	17	possibly	possibly	RB
cord-001835-0s7ok4uw	2296	18	allowing	allow	VBG
cord-001835-0s7ok4uw	2296	19	it	-PRON-	PRP
cord-001835-0s7ok4uw	2296	20	to	to	TO
cord-001835-0s7ok4uw	2296	21	interact	interact	VB
cord-001835-0s7ok4uw	2296	22	with	with	IN
cord-001835-0s7ok4uw	2296	23	different	different	JJ
cord-001835-0s7ok4uw	2296	24	protein	protein	NN
cord-001835-0s7ok4uw	2296	25	partners	partner	NNS
cord-001835-0s7ok4uw	2296	26	,	,	,
cord-001835-0s7ok4uw	2296	27	such	such	JJ
cord-001835-0s7ok4uw	2296	28	as	as	IN
cord-001835-0s7ok4uw	2296	29	UreE	UreE	NNP
cord-001835-0s7ok4uw	2296	30	(	(	-LRB-
cord-001835-0s7ok4uw	2296	31	3	3	CD
cord-001835-0s7ok4uw	2296	32	,	,	,
cord-001835-0s7ok4uw	2296	33	4	4	CD
cord-001835-0s7ok4uw	2296	34	)	)	-RRB-
cord-001835-0s7ok4uw	2296	35	and	and	CC
cord-001835-0s7ok4uw	2296	36	UreF	UreF	NNP
cord-001835-0s7ok4uw	2296	37	(	(	-LRB-
cord-001835-0s7ok4uw	2296	38	5	5	CD
cord-001835-0s7ok4uw	2296	39	)	)	-RRB-
cord-001835-0s7ok4uw	2296	40	and	and	CC
cord-001835-0s7ok4uw	2296	41	cofactors	cofactor	NNS
cord-001835-0s7ok4uw	2296	42	,	,	,
cord-001835-0s7ok4uw	2296	43	such	such	JJ
cord-001835-0s7ok4uw	2296	44	as	as	IN
cord-001835-0s7ok4uw	2296	45	metal	metal	NN
cord-001835-0s7ok4uw	2296	46	ions	ion	NNS
cord-001835-0s7ok4uw	2296	47	(	(	-LRB-
cord-001835-0s7ok4uw	2296	48	6	6	CD
cord-001835-0s7ok4uw	2296	49	)	)	-RRB-
cord-001835-0s7ok4uw	2296	50	,	,	,
cord-001835-0s7ok4uw	2296	51	in	in	IN
cord-001835-0s7ok4uw	2296	52	the	the	DT
cord-001835-0s7ok4uw	2296	53	urease	urease	NNP
cord-001835-0s7ok4uw	2296	54	activation	activation	NN
cord-001835-0s7ok4uw	2296	55	network	network	NN
cord-001835-0s7ok4uw	2296	56	.	.	.
cord-001835-0s7ok4uw	2297	1	UreG	UreG	NNP
cord-001835-0s7ok4uw	2297	2	folding	folding	NN
cord-001835-0s7ok4uw	2297	3	was	be	VBD
cord-001835-0s7ok4uw	2297	4	studied	study	VBN
cord-001835-0s7ok4uw	2297	5	perturbing	perturb	VBG
cord-001835-0s7ok4uw	2297	6	protein	protein	NN
cord-001835-0s7ok4uw	2297	7	conformation	conformation	NN
cord-001835-0s7ok4uw	2297	8	with	with	IN
cord-001835-0s7ok4uw	2297	9	temperature	temperature	NN
cord-001835-0s7ok4uw	2297	10	and	and	CC
cord-001835-0s7ok4uw	2297	11	denaturants	denaturant	NNS
cord-001835-0s7ok4uw	2297	12	,	,	,
cord-001835-0s7ok4uw	2297	13	and	and	CC
cord-001835-0s7ok4uw	2297	14	investigating	investigate	VBG
cord-001835-0s7ok4uw	2297	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2297	16	folding	folding	NN
cord-001835-0s7ok4uw	2297	17	response	response	NN
cord-001835-0s7ok4uw	2297	18	using	use	VBG
cord-001835-0s7ok4uw	2297	19	circular	circular	JJ
cord-001835-0s7ok4uw	2297	20	dichroism	dichroism	NN
cord-001835-0s7ok4uw	2297	21	,	,	,
cord-001835-0s7ok4uw	2297	22	NMR	nmr	NN
cord-001835-0s7ok4uw	2297	23	and	and	CC
cord-001835-0s7ok4uw	2297	24	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2297	25	(	(	-LRB-
cord-001835-0s7ok4uw	2297	26	7	7	CD
cord-001835-0s7ok4uw	2297	27	)	)	-RRB-
cord-001835-0s7ok4uw	2297	28	.	.	.
cord-001835-0s7ok4uw	2298	1	A	a	DT
cord-001835-0s7ok4uw	2298	2	combination	combination	NN
cord-001835-0s7ok4uw	2298	3	of	of	IN
cord-001835-0s7ok4uw	2298	4	light	light	JJ
cord-001835-0s7ok4uw	2298	5	scattering	scattering	NN
cord-001835-0s7ok4uw	2298	6	,	,	,
cord-001835-0s7ok4uw	2298	7	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	2298	8	,	,	,
cord-001835-0s7ok4uw	2298	9	mass	mass	NN
cord-001835-0s7ok4uw	2298	10	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	2298	11	,	,	,
cord-001835-0s7ok4uw	2298	12	and	and	CC
cord-001835-0s7ok4uw	2298	13	NMR	NMR	NNP
cord-001835-0s7ok4uw	2298	14	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2298	15	shed	shed	VBN
cord-001835-0s7ok4uw	2298	16	light	light	NN
cord-001835-0s7ok4uw	2298	17	on	on	IN
cord-001835-0s7ok4uw	2298	18	the	the	DT
cord-001835-0s7ok4uw	2298	19	effect	effect	NN
cord-001835-0s7ok4uw	2298	20	of	of	IN
cord-001835-0s7ok4uw	2298	21	metal	metal	NN
cord-001835-0s7ok4uw	2298	22	ion	ion	NN
cord-001835-0s7ok4uw	2298	23	binding	binding	NN
cord-001835-0s7ok4uw	2298	24	onto	onto	IN
cord-001835-0s7ok4uw	2298	25	the	the	DT
cord-001835-0s7ok4uw	2298	26	conformational	conformational	JJ
cord-001835-0s7ok4uw	2298	27	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	2298	28	of	of	IN
cord-001835-0s7ok4uw	2298	29	UreG	UreG	NNP
cord-001835-0s7ok4uw	2298	30	ensemble	ensemble	NN
cord-001835-0s7ok4uw	2298	31	(	(	-LRB-
cord-001835-0s7ok4uw	2298	32	8)	8)	NNP
cord-001835-0s7ok4uw	2298	33	.	.	.
cord-001835-0s7ok4uw	2299	1	The	the	DT
cord-001835-0s7ok4uw	2299	2	results	result	NNS
cord-001835-0s7ok4uw	2299	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	2299	4	that	that	IN
cord-001835-0s7ok4uw	2299	5	metal	metal	NN
cord-001835-0s7ok4uw	2299	6	binding	binding	NN
cord-001835-0s7ok4uw	2299	7	and	and	CC
cord-001835-0s7ok4uw	2299	8	solution	solution	NN
cord-001835-0s7ok4uw	2299	9	conditions	condition	NNS
cord-001835-0s7ok4uw	2299	10	modulate	modulate	VBP
cord-001835-0s7ok4uw	2299	11	affect	affect	VB
cord-001835-0s7ok4uw	2299	12	the	the	DT
cord-001835-0s7ok4uw	2299	13	protein	protein	NN
cord-001835-0s7ok4uw	2299	14	-	-	HYPH
cord-001835-0s7ok4uw	2299	15	protein	protein	NN
cord-001835-0s7ok4uw	2299	16	interactions	interaction	NNS
cord-001835-0s7ok4uw	2299	17	and	and	CC
cord-001835-0s7ok4uw	2299	18	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	2299	19	activity	activity	NN
cord-001835-0s7ok4uw	2299	20	of	of	IN
cord-001835-0s7ok4uw	2299	21	UreG.	UreG.	NNP
cord-001835-0s7ok4uw	2299	22	 	 	_SP
cord-001835-0s7ok4uw	2299	23	Nuclear	Nuclear	NNP
cord-001835-0s7ok4uw	2299	24	Inclusion	Inclusion	NNP
cord-001835-0s7ok4uw	2299	25	protein	protein	NN
cord-001835-0s7ok4uw	2299	26	A	a	NN
cord-001835-0s7ok4uw	2299	27	-	-	HYPH
cord-001835-0s7ok4uw	2299	28	protease	protease	NN
cord-001835-0s7ok4uw	2299	29	(	(	-LRB-
cord-001835-0s7ok4uw	2299	30	NIa	nia	JJ
cord-001835-0s7ok4uw	2299	31	-	-	HYPH
cord-001835-0s7ok4uw	2299	32	pro	pro	NNP
cord-001835-0s7ok4uw	2299	33	)	)	-RRB-
cord-001835-0s7ok4uw	2299	34	is	be	VBZ
cord-001835-0s7ok4uw	2299	35	a	a	DT
cord-001835-0s7ok4uw	2299	36	protease	protease	NN
cord-001835-0s7ok4uw	2299	37	involved	involve	VBN
cord-001835-0s7ok4uw	2299	38	in	in	IN
cord-001835-0s7ok4uw	2299	39	processing	processing	NN
cord-001835-0s7ok4uw	2299	40	of	of	IN
cord-001835-0s7ok4uw	2299	41	Pepper	Pepper	NNP
cord-001835-0s7ok4uw	2299	42	vein	vein	NN
cord-001835-0s7ok4uw	2299	43	banding	banding	NN
cord-001835-0s7ok4uw	2299	44	virus	virus	NN
cord-001835-0s7ok4uw	2299	45	(	(	-LRB-
cord-001835-0s7ok4uw	2299	46	PVBV	PVBV	NNP
cord-001835-0s7ok4uw	2299	47	)	)	-RRB-
cord-001835-0s7ok4uw	2299	48	encoded	encode	VBD
cord-001835-0s7ok4uw	2299	49	polyprotein	polyprotein	NN
cord-001835-0s7ok4uw	2299	50	to	to	TO
cord-001835-0s7ok4uw	2299	51	generate	generate	VB
cord-001835-0s7ok4uw	2299	52	various	various	JJ
cord-001835-0s7ok4uw	2299	53	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	2299	54	and	and	CC
cord-001835-0s7ok4uw	2299	55	mature	mature	VB
cord-001835-0s7ok4uw	2299	56	proteins	protein	NNS
cord-001835-0s7ok4uw	2299	57	at	at	IN
cord-001835-0s7ok4uw	2299	58	different	different	JJ
cord-001835-0s7ok4uw	2299	59	stages	stage	NNS
cord-001835-0s7ok4uw	2299	60	of	of	IN
cord-001835-0s7ok4uw	2299	61	the	the	DT
cord-001835-0s7ok4uw	2299	62	viral	viral	JJ
cord-001835-0s7ok4uw	2299	63	life	life	NN
cord-001835-0s7ok4uw	2299	64	-	-	HYPH
cord-001835-0s7ok4uw	2299	65	cycle	cycle	NN
cord-001835-0s7ok4uw	2299	66	.	.	.
cord-001835-0s7ok4uw	2300	1	NIa	NIa	NNP
cord-001835-0s7ok4uw	2300	2	-	-	HYPH
cord-001835-0s7ok4uw	2300	3	Pro	Pro	NNP
cord-001835-0s7ok4uw	2300	4	has	have	VBZ
cord-001835-0s7ok4uw	2300	5	two	two	CD
cord-001835-0s7ok4uw	2300	6	domains	domain	NNS
cord-001835-0s7ok4uw	2300	7	-	-	HYPH
cord-001835-0s7ok4uw	2300	8	N	n	NN
cord-001835-0s7ok4uw	2300	9	-	-	HYPH
cord-001835-0s7ok4uw	2300	10	terminal	terminal	NN
cord-001835-0s7ok4uw	2300	11	Viral	Viral	NNP
cord-001835-0s7ok4uw	2300	12	protein	protein	NN
cord-001835-0s7ok4uw	2300	13	genome	genome	NN
cord-001835-0s7ok4uw	2300	14	linked	link	VBN
cord-001835-0s7ok4uw	2300	15	(	(	-LRB-
cord-001835-0s7ok4uw	2300	16	VPg	VPg	NNS
cord-001835-0s7ok4uw	2300	17	)	)	-RRB-
cord-001835-0s7ok4uw	2300	18	and	and	CC
cord-001835-0s7ok4uw	2300	19	the	the	DT
cord-001835-0s7ok4uw	2300	20	C	C	NNP
cord-001835-0s7ok4uw	2300	21	-	-	HYPH
cord-001835-0s7ok4uw	2300	22	terminal	terminal	NN
cord-001835-0s7ok4uw	2300	23	protease	protease	NN
cord-001835-0s7ok4uw	2300	24	domain	domain	NN
cord-001835-0s7ok4uw	2300	25	(	(	-LRB-
cord-001835-0s7ok4uw	2300	26	Pro).VPg	pro).vpg	NN
cord-001835-0s7ok4uw	2300	27	belongs	belong	VBZ
cord-001835-0s7ok4uw	2300	28	to	to	IN
cord-001835-0s7ok4uw	2300	29	the	the	DT
cord-001835-0s7ok4uw	2300	30	group	group	NN
cord-001835-0s7ok4uw	2300	31	of	of	IN
cord-001835-0s7ok4uw	2300	32	proteins	protein	NNS
cord-001835-0s7ok4uw	2300	33	that	that	WDT
cord-001835-0s7ok4uw	2300	34	are	be	VBP
cord-001835-0s7ok4uw	2300	35	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2300	36	disordered	disordered	JJ
cord-001835-0s7ok4uw	2300	37	,	,	,
cord-001835-0s7ok4uw	2300	38	but	but	CC
cord-001835-0s7ok4uw	2300	39	attain	attain	VB
cord-001835-0s7ok4uw	2300	40	stable	stable	JJ
cord-001835-0s7ok4uw	2300	41	structures	structure	NNS
cord-001835-0s7ok4uw	2300	42	upon	upon	IN
cord-001835-0s7ok4uw	2300	43	interaction	interaction	NN
cord-001835-0s7ok4uw	2300	44	with	with	IN
cord-001835-0s7ok4uw	2300	45	other	other	JJ
cord-001835-0s7ok4uw	2300	46	globular	globular	JJ
cord-001835-0s7ok4uw	2300	47	proteins	protein	NNS
cord-001835-0s7ok4uw	2300	48	.	.	.
cord-001835-0s7ok4uw	2301	1	Such	such	JJ
cord-001835-0s7ok4uw	2301	2	proteinprotein	proteinprotein	NNP
cord-001835-0s7ok4uw	2301	3	interactions	interaction	NNS
cord-001835-0s7ok4uw	2301	4	have	have	VBP
cord-001835-0s7ok4uw	2301	5	a	a	DT
cord-001835-0s7ok4uw	2301	6	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	2301	7	role	role	NN
cord-001835-0s7ok4uw	2301	8	on	on	IN
cord-001835-0s7ok4uw	2301	9	the	the	DT
cord-001835-0s7ok4uw	2301	10	function	function	NN
cord-001835-0s7ok4uw	2301	11	of	of	IN
cord-001835-0s7ok4uw	2301	12	the	the	DT
cord-001835-0s7ok4uw	2301	13	interacting	interact	VBG
cord-001835-0s7ok4uw	2301	14	partners	partner	NNS
cord-001835-0s7ok4uw	2301	15	.	.	.
cord-001835-0s7ok4uw	2302	1	Previously	previously	RB
cord-001835-0s7ok4uw	2302	2	,	,	,
cord-001835-0s7ok4uw	2302	3	the	the	DT
cord-001835-0s7ok4uw	2302	4	influence	influence	NN
cord-001835-0s7ok4uw	2302	5	of	of	IN
cord-001835-0s7ok4uw	2302	6	VPg	VPg	NNS
cord-001835-0s7ok4uw	2302	7	domain	domain	NN
cord-001835-0s7ok4uw	2302	8	on	on	IN
cord-001835-0s7ok4uw	2302	9	the	the	DT
cord-001835-0s7ok4uw	2302	10	activity	activity	NN
cord-001835-0s7ok4uw	2302	11	of	of	IN
cord-001835-0s7ok4uw	2302	12	Pro	Pro	NNP
cord-001835-0s7ok4uw	2302	13	was	be	VBD
cord-001835-0s7ok4uw	2302	14	studied	study	VBN
cord-001835-0s7ok4uw	2302	15	and	and	CC
cord-001835-0s7ok4uw	2302	16	it	-PRON-	PRP
cord-001835-0s7ok4uw	2302	17	was	be	VBD
cord-001835-0s7ok4uw	2302	18	shown	show	VBN
cord-001835-0s7ok4uw	2302	19	that	that	IN
cord-001835-0s7ok4uw	2302	20	there	there	EX
cord-001835-0s7ok4uw	2302	21	was	be	VBD
cord-001835-0s7ok4uw	2302	22	a	a	DT
cord-001835-0s7ok4uw	2302	23	substantial	substantial	JJ
cord-001835-0s7ok4uw	2302	24	increase	increase	NN
cord-001835-0s7ok4uw	2302	25	in	in	IN
cord-001835-0s7ok4uw	2302	26	the	the	DT
cord-001835-0s7ok4uw	2302	27	protease	protease	NN
cord-001835-0s7ok4uw	2302	28	activity	activity	NN
cord-001835-0s7ok4uw	2302	29	upon	upon	IN
cord-001835-0s7ok4uw	2302	30	interaction	interaction	NN
cord-001835-0s7ok4uw	2302	31	with	with	IN
cord-001835-0s7ok4uw	2302	32	VPg	VPg	NNS
cord-001835-0s7ok4uw	2302	33	(	(	-LRB-
cord-001835-0s7ok4uw	2302	34	both	both	DT
cord-001835-0s7ok4uw	2302	35	in	in	IN
cord-001835-0s7ok4uw	2302	36	cis	cis	NNP
cord-001835-0s7ok4uw	2302	37	and	and	CC
cord-001835-0s7ok4uw	2302	38	in	in	IN
cord-001835-0s7ok4uw	2302	39	trans	trans	NNP
cord-001835-0s7ok4uw	2302	40	)	)	-RRB-
cord-001835-0s7ok4uw	2302	41	.	.	.
cord-001835-0s7ok4uw	2303	1	In	in	IN
cord-001835-0s7ok4uw	2303	2	the	the	DT
cord-001835-0s7ok4uw	2303	3	present	present	JJ
cord-001835-0s7ok4uw	2303	4	investigation	investigation	NN
cord-001835-0s7ok4uw	2303	5	,	,	,
cord-001835-0s7ok4uw	2303	6	several	several	JJ
cord-001835-0s7ok4uw	2303	7	deletion	deletion	NN
cord-001835-0s7ok4uw	2303	8	mutants	mutant	NNS
cord-001835-0s7ok4uw	2303	9	of	of	IN
cord-001835-0s7ok4uw	2303	10	VPg	VPg	NNS
cord-001835-0s7ok4uw	2303	11	and	and	CC
cord-001835-0s7ok4uw	2303	12	NIa	NIa	NNP
cord-001835-0s7ok4uw	2303	13	were	be	VBD
cord-001835-0s7ok4uw	2303	14	constructed	construct	VBN
cord-001835-0s7ok4uw	2303	15	with	with	IN
cord-001835-0s7ok4uw	2303	16	a	a	DT
cord-001835-0s7ok4uw	2303	17	view	view	NN
cord-001835-0s7ok4uw	2303	18	to	to	TO
cord-001835-0s7ok4uw	2303	19	delineate	delineate	VB
cord-001835-0s7ok4uw	2303	20	the	the	DT
cord-001835-0s7ok4uw	2303	21	domain	domain	NN
cord-001835-0s7ok4uw	2303	22	of	of	IN
cord-001835-0s7ok4uw	2303	23	VPg	VPg	NNS
cord-001835-0s7ok4uw	2303	24	involved	involve	VBN
cord-001835-0s7ok4uw	2303	25	in	in	IN
cord-001835-0s7ok4uw	2303	26	interaction	interaction	NN
cord-001835-0s7ok4uw	2303	27	with	with	IN
cord-001835-0s7ok4uw	2303	28	Pro	Pro	NNP
cord-001835-0s7ok4uw	2303	29	.	.	.
cord-001835-0s7ok4uw	2304	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2304	2	was	be	VBD
cord-001835-0s7ok4uw	2304	3	observed	observe	VBN
cord-001835-0s7ok4uw	2304	4	that	that	IN
cord-001835-0s7ok4uw	2304	5	deletion	deletion	NN
cord-001835-0s7ok4uw	2304	6	of	of	IN
cord-001835-0s7ok4uw	2304	7	residues	residue	NNS
cord-001835-0s7ok4uw	2304	8	from	from	IN
cord-001835-0s7ok4uw	2304	9	Nterminus	Nterminus	NNP
cord-001835-0s7ok4uw	2304	10	of	of	IN
cord-001835-0s7ok4uw	2304	11	VPg	VPg	NNS
cord-001835-0s7ok4uw	2304	12	resulted	result	VBD
cord-001835-0s7ok4uw	2304	13	in	in	IN
cord-001835-0s7ok4uw	2304	14	a	a	DT
cord-001835-0s7ok4uw	2304	15	decrease	decrease	NN
cord-001835-0s7ok4uw	2304	16	in	in	IN
cord-001835-0s7ok4uw	2304	17	the	the	DT
cord-001835-0s7ok4uw	2304	18	activity	activity	NN
cord-001835-0s7ok4uw	2304	19	of	of	IN
cord-001835-0s7ok4uw	2304	20	Pro	Pro	NNP
cord-001835-0s7ok4uw	2304	21	in	in	IN
cord-001835-0s7ok4uw	2304	22	cis	cis	NNP
cord-001835-0s7ok4uw	2304	23	and	and	CC
cord-001835-0s7ok4uw	2304	24	in	in	IN
cord-001835-0s7ok4uw	2304	25	trans	trans	NNP
cord-001835-0s7ok4uw	2304	26	probably	probably	RB
cord-001835-0s7ok4uw	2304	27	because	because	IN
cord-001835-0s7ok4uw	2304	28	of	of	IN
cord-001835-0s7ok4uw	2304	29	the	the	DT
cord-001835-0s7ok4uw	2304	30	abrogation	abrogation	NN
cord-001835-0s7ok4uw	2304	31	of	of	IN
cord-001835-0s7ok4uw	2304	32	interaction	interaction	NN
cord-001835-0s7ok4uw	2304	33	between	between	IN
cord-001835-0s7ok4uw	2304	34	the	the	DT
cord-001835-0s7ok4uw	2304	35	two	two	CD
cord-001835-0s7ok4uw	2304	36	domains	domain	NNS
cord-001835-0s7ok4uw	2304	37	.	.	.
cord-001835-0s7ok4uw	2305	1	Interaction	interaction	NN
cord-001835-0s7ok4uw	2305	2	studies	study	NNS
cord-001835-0s7ok4uw	2305	3	using	use	VBG
cord-001835-0s7ok4uw	2305	4	SPR	SPR	NNP
cord-001835-0s7ok4uw	2305	5	(	(	-LRB-
cord-001835-0s7ok4uw	2305	6	Surface	Surface	NNP
cord-001835-0s7ok4uw	2305	7	Plasmon	Plasmon	NNP
cord-001835-0s7ok4uw	2305	8	Resonance	Resonance	NNP
cord-001835-0s7ok4uw	2305	9	)	)	-RRB-
cord-001835-0s7ok4uw	2305	10	and	and	CC
cord-001835-0s7ok4uw	2305	11	ELISA	ELISA	NNP
cord-001835-0s7ok4uw	2305	12	confirmed	confirm	VBD
cord-001835-0s7ok4uw	2305	13	that	that	IN
cord-001835-0s7ok4uw	2305	14	the	the	DT
cord-001835-0s7ok4uw	2305	15	N	n	CD
cord-001835-0s7ok4uw	2305	16	-	-	HYPH
cord-001835-0s7ok4uw	2305	17	terminal	terminal	JJ
cord-001835-0s7ok4uw	2305	18	22	22	CD
cord-001835-0s7ok4uw	2305	19	residues	residue	NNS
cord-001835-0s7ok4uw	2305	20	of	of	IN
cord-001835-0s7ok4uw	2305	21	VPg	VPg	NNS
cord-001835-0s7ok4uw	2305	22	are	be	VBP
cord-001835-0s7ok4uw	2305	23	important	important	JJ
cord-001835-0s7ok4uw	2305	24	for	for	IN
cord-001835-0s7ok4uw	2305	25	interaction	interaction	NN
cord-001835-0s7ok4uw	2305	26	with	with	IN
cord-001835-0s7ok4uw	2305	27	Pro	Pro	NNP
cord-001835-0s7ok4uw	2305	28	.	.	.
cord-001835-0s7ok4uw	2306	1	The	the	DT
cord-001835-0s7ok4uw	2306	2	N	n	CD
cord-001835-0s7ok4uw	2306	3	-	-	HYPH
cord-001835-0s7ok4uw	2306	4	terminal	terminal	JJ
cord-001835-0s7ok4uw	2306	5	22	22	CD
cord-001835-0s7ok4uw	2306	6	residues	residue	NNS
cord-001835-0s7ok4uw	2306	7	of	of	IN
cord-001835-0s7ok4uw	2306	8	VPg	VPg	NNS
cord-001835-0s7ok4uw	2306	9	are	be	VBP
cord-001835-0s7ok4uw	2306	10	a	a	DT
cord-001835-0s7ok4uw	2306	11	part	part	NN
cord-001835-0s7ok4uw	2306	12	of	of	IN
cord-001835-0s7ok4uw	2306	13	the	the	DT
cord-001835-0s7ok4uw	2306	14	disordered	disordered	JJ
cord-001835-0s7ok4uw	2306	15	region	region	NN
cord-001835-0s7ok4uw	2306	16	of	of	IN
cord-001835-0s7ok4uw	2306	17	VPg	VPg	NNS
cord-001835-0s7ok4uw	2306	18	and	and	CC
cord-001835-0s7ok4uw	2306	19	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2306	20	deletion	deletion	NN
cord-001835-0s7ok4uw	2306	21	resulted	result	VBD
cord-001835-0s7ok4uw	2306	22	in	in	IN
cord-001835-0s7ok4uw	2306	23	the	the	DT
cord-001835-0s7ok4uw	2306	24	change	change	NN
cord-001835-0s7ok4uw	2306	25	in	in	IN
cord-001835-0s7ok4uw	2306	26	the	the	DT
cord-001835-0s7ok4uw	2306	27	secondary	secondary	JJ
cord-001835-0s7ok4uw	2306	28	structure	structure	NN
cord-001835-0s7ok4uw	2306	29	of	of	IN
cord-001835-0s7ok4uw	2306	30	the	the	DT
cord-001835-0s7ok4uw	2306	31	VPg	VPg	NNS
cord-001835-0s7ok4uw	2306	32	and	and	CC
cord-001835-0s7ok4uw	2306	33	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2306	34	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2306	35	state	state	NN
cord-001835-0s7ok4uw	2306	36	.	.	.
cord-001835-0s7ok4uw	2307	1	The	the	DT
cord-001835-0s7ok4uw	2307	2	Ser	Ser	NNP
cord-001835-0s7ok4uw	2307	3	129	129	CD
cord-001835-0s7ok4uw	2307	4	and	and	CC
cord-001835-0s7ok4uw	2307	5	Trp	Trp	NNP
cord-001835-0s7ok4uw	2307	6	143	143	CD
cord-001835-0s7ok4uw	2307	7	residues	residue	NNS
cord-001835-0s7ok4uw	2307	8	of	of	IN
cord-001835-0s7ok4uw	2307	9	Pro	pro	JJ
cord-001835-0s7ok4uw	2307	10	domain	domain	NN
cord-001835-0s7ok4uw	2307	11	were	be	VBD
cord-001835-0s7ok4uw	2307	12	shown	show	VBN
cord-001835-0s7ok4uw	2307	13	to	to	TO
cord-001835-0s7ok4uw	2307	14	be	be	VB
cord-001835-0s7ok4uw	2307	15	important	important	JJ
cord-001835-0s7ok4uw	2307	16	both	both	DT
cord-001835-0s7ok4uw	2307	17	for	for	IN
cord-001835-0s7ok4uw	2307	18	the	the	DT
cord-001835-0s7ok4uw	2307	19	interaction	interaction	NN
cord-001835-0s7ok4uw	2307	20	of	of	IN
cord-001835-0s7ok4uw	2307	21	the	the	DT
cord-001835-0s7ok4uw	2307	22	two	two	CD
cord-001835-0s7ok4uw	2307	23	domains	domain	NNS
cord-001835-0s7ok4uw	2307	24	and	and	CC
cord-001835-0s7ok4uw	2307	25	for	for	IN
cord-001835-0s7ok4uw	2307	26	the	the	DT
cord-001835-0s7ok4uw	2307	27	activity	activity	NN
cord-001835-0s7ok4uw	2307	28	of	of	IN
cord-001835-0s7ok4uw	2307	29	protease	protease	NN
cord-001835-0s7ok4uw	2307	30	by	by	IN
cord-001835-0s7ok4uw	2307	31	mutational	mutational	JJ
cord-001835-0s7ok4uw	2307	32	analysis	analysis	NN
cord-001835-0s7ok4uw	2307	33	earlier	early	RBR
cord-001835-0s7ok4uw	2307	34	.	.	.
cord-001835-0s7ok4uw	2308	1	These	these	DT
cord-001835-0s7ok4uw	2308	2	residues	residue	NNS
cord-001835-0s7ok4uw	2308	3	were	be	VBD
cord-001835-0s7ok4uw	2308	4	identified	identify	VBN
cord-001835-0s7ok4uw	2308	5	to	to	TO
cord-001835-0s7ok4uw	2308	6	be	be	VB
cord-001835-0s7ok4uw	2308	7	a	a	DT
cord-001835-0s7ok4uw	2308	8	part	part	NN
cord-001835-0s7ok4uw	2308	9	of	of	IN
cord-001835-0s7ok4uw	2308	10	WC	WC	NNP
cord-001835-0s7ok4uw	2308	11	loop	loop	NN
cord-001835-0s7ok4uw	2308	12	(	(	-LRB-
cord-001835-0s7ok4uw	2308	13	W143-C151	W143-C151	NNP
cord-001835-0s7ok4uw	2308	14	)	)	-RRB-
cord-001835-0s7ok4uw	2308	15	which	which	WDT
cord-001835-0s7ok4uw	2308	16	relay	relay	VBP
cord-001835-0s7ok4uw	2308	17	the	the	DT
cord-001835-0s7ok4uw	2308	18	conformational	conformational	JJ
cord-001835-0s7ok4uw	2308	19	changes	change	NNS
cord-001835-0s7ok4uw	2308	20	to	to	IN
cord-001835-0s7ok4uw	2308	21	the	the	DT
cord-001835-0s7ok4uw	2308	22	active	active	JJ
cord-001835-0s7ok4uw	2308	23	site	site	NN
cord-001835-0s7ok4uw	2308	24	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2308	25	triad	triad	NN
cord-001835-0s7ok4uw	2308	26	(	(	-LRB-
cord-001835-0s7ok4uw	2308	27	His	-PRON-	PRP$
cord-001835-0s7ok4uw	2308	28	46	46	CD
cord-001835-0s7ok4uw	2308	29	,	,	,
cord-001835-0s7ok4uw	2308	30	Asp	Asp	NNP
cord-001835-0s7ok4uw	2308	31	81	81	CD
cord-001835-0s7ok4uw	2308	32	and	and	CC
cord-001835-0s7ok4uw	2308	33	Cys	Cys	NNP
cord-001835-0s7ok4uw	2308	34	151	151	CD
cord-001835-0s7ok4uw	2308	35	)	)	-RRB-
cord-001835-0s7ok4uw	2308	36	leading	lead	VBG
cord-001835-0s7ok4uw	2308	37	to	to	IN
cord-001835-0s7ok4uw	2308	38	activation	activation	NN
cord-001835-0s7ok4uw	2308	39	.	.	.
cord-001835-0s7ok4uw	2309	1	However	however	RB
cord-001835-0s7ok4uw	2309	2	,	,	,
cord-001835-0s7ok4uw	2309	3	mutations	mutation	NNS
cord-001835-0s7ok4uw	2309	4	of	of	IN
cord-001835-0s7ok4uw	2309	5	these	these	DT
cord-001835-0s7ok4uw	2309	6	residues	residue	NNS
cord-001835-0s7ok4uw	2309	7	did	do	VBD
cord-001835-0s7ok4uw	2309	8	not	not	RB
cord-001835-0s7ok4uw	2309	9	completely	completely	RB
cord-001835-0s7ok4uw	2309	10	abolish	abolish	VB
cord-001835-0s7ok4uw	2309	11	the	the	DT
cord-001835-0s7ok4uw	2309	12	protease	protease	NN
cord-001835-0s7ok4uw	2309	13	activity	activity	NN
cord-001835-0s7ok4uw	2309	14	as	as	RB
cord-001835-0s7ok4uw	2309	15	well	well	RB
cord-001835-0s7ok4uw	2309	16	as	as	IN
cord-001835-0s7ok4uw	2309	17	the	the	DT
cord-001835-0s7ok4uw	2309	18	interaction	interaction	NN
cord-001835-0s7ok4uw	2309	19	with	with	IN
cord-001835-0s7ok4uw	2309	20	VPg	VPg	NNS
cord-001835-0s7ok4uw	2309	21	.	.	.
cord-001835-0s7ok4uw	2310	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	2310	2	,	,	,
cord-001835-0s7ok4uw	2310	3	in	in	IN
cord-001835-0s7ok4uw	2310	4	the	the	DT
cord-001835-0s7ok4uw	2310	5	present	present	JJ
cord-001835-0s7ok4uw	2310	6	study	study	NN
cord-001835-0s7ok4uw	2310	7	H142	H142	NNS
cord-001835-0s7ok4uw	2310	8	and	and	CC
cord-001835-0s7ok4uw	2310	9	H167	H167	NNS
cord-001835-0s7ok4uw	2310	10	which	which	WDT
cord-001835-0s7ok4uw	2310	11	are	be	VBP
cord-001835-0s7ok4uw	2310	12	observed	observe	VBN
cord-001835-0s7ok4uw	2310	13	to	to	TO
cord-001835-0s7ok4uw	2310	14	interact	interact	VB
cord-001835-0s7ok4uw	2310	15	with	with	IN
cord-001835-0s7ok4uw	2310	16	Trp143	trp143	CD
cord-001835-0s7ok4uw	2310	17	and	and	CC
cord-001835-0s7ok4uw	2310	18	C151	C151	.
cord-001835-0s7ok4uw	2311	1	(	(	-LRB-
cord-001835-0s7ok4uw	2311	2	via	via	IN
cord-001835-0s7ok4uw	2311	3	non	non	JJ
cord-001835-0s7ok4uw	2311	4	-	-	JJ
cord-001835-0s7ok4uw	2311	5	covalent	covalent	JJ
cord-001835-0s7ok4uw	2311	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	2311	7	)	)	-RRB-
cord-001835-0s7ok4uw	2311	8	were	be	VBD
cord-001835-0s7ok4uw	2311	9	mutated	mutate	VBN
cord-001835-0s7ok4uw	2311	10	to	to	IN
cord-001835-0s7ok4uw	2311	11	alanine	alanine	NN
cord-001835-0s7ok4uw	2311	12	and	and	CC
cord-001835-0s7ok4uw	2311	13	the	the	DT
cord-001835-0s7ok4uw	2311	14	H142A	H142A	NNP
cord-001835-0s7ok4uw	2311	15	and	and	CC
cord-001835-0s7ok4uw	2311	16	H167A	H167A	NNP
cord-001835-0s7ok4uw	2311	17	mutants	mutant	NNS
cord-001835-0s7ok4uw	2311	18	showed	show	VBD
cord-001835-0s7ok4uw	2311	19	a	a	DT
cord-001835-0s7ok4uw	2311	20	drastic	drastic	JJ
cord-001835-0s7ok4uw	2311	21	reduction	reduction	NN
cord-001835-0s7ok4uw	2311	22	in	in	IN
cord-001835-0s7ok4uw	2311	23	the	the	DT
cord-001835-0s7ok4uw	2311	24	activity	activity	NN
cord-001835-0s7ok4uw	2311	25	of	of	IN
cord-001835-0s7ok4uw	2311	26	Protease	Protease	NNP
cord-001835-0s7ok4uw	2311	27	.	.	.
cord-001835-0s7ok4uw	2312	1	Molecular	molecular	JJ
cord-001835-0s7ok4uw	2312	2	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2312	3	simulations	simulation	NNS
cord-001835-0s7ok4uw	2312	4	of	of	IN
cord-001835-0s7ok4uw	2312	5	the	the	DT
cord-001835-0s7ok4uw	2312	6	wild	wild	JJ
cord-001835-0s7ok4uw	2312	7	type	type	NN
cord-001835-0s7ok4uw	2312	8	pro	pro	JJ
cord-001835-0s7ok4uw	2312	9	and	and	CC
cord-001835-0s7ok4uw	2312	10	the	the	DT
cord-001835-0s7ok4uw	2312	11	mutants	mutant	NNS
cord-001835-0s7ok4uw	2312	12	revealed	reveal	VBD
cord-001835-0s7ok4uw	2312	13	that	that	IN
cord-001835-0s7ok4uw	2312	14	Trp	Trp	NNP
cord-001835-0s7ok4uw	2312	15	143	143	CD
cord-001835-0s7ok4uw	2312	16	-His	-his	SYM
cord-001835-0s7ok4uw	2312	17	142	142	CD
cord-001835-0s7ok4uw	2312	18	-His	-his	SYM
cord-001835-0s7ok4uw	2312	19	167	167	CD
cord-001835-0s7ok4uw	2312	20	-Cys	-cys	SYM
cord-001835-0s7ok4uw	2312	21	151	151	CD
cord-001835-0s7ok4uw	2312	22	interaction	interaction	NN
cord-001835-0s7ok4uw	2312	23	pathway	pathway	NN
cord-001835-0s7ok4uw	2312	24	of	of	IN
cord-001835-0s7ok4uw	2312	25	the	the	DT
cord-001835-0s7ok4uw	2312	26	wild	wild	JJ
cord-001835-0s7ok4uw	2312	27	type	type	NN
cord-001835-0s7ok4uw	2312	28	Pro	Pro	NNP
cord-001835-0s7ok4uw	2312	29	was	be	VBD
cord-001835-0s7ok4uw	2312	30	disrupted	disrupt	VBN
cord-001835-0s7ok4uw	2312	31	in	in	IN
cord-001835-0s7ok4uw	2312	32	the	the	DT
cord-001835-0s7ok4uw	2312	33	mutants	mutant	NNS
cord-001835-0s7ok4uw	2312	34	and	and	CC
cord-001835-0s7ok4uw	2312	35	additional	additional	JJ
cord-001835-0s7ok4uw	2312	36	residues	residue	NNS
cord-001835-0s7ok4uw	2312	37	were	be	VBD
cord-001835-0s7ok4uw	2312	38	involved	involve	VBN
cord-001835-0s7ok4uw	2312	39	in	in	IN
cord-001835-0s7ok4uw	2312	40	the	the	DT
cord-001835-0s7ok4uw	2312	41	interaction	interaction	NN
cord-001835-0s7ok4uw	2312	42	pathway	pathway	NN
cord-001835-0s7ok4uw	2312	43	,	,	,
cord-001835-0s7ok4uw	2312	44	such	such	JJ
cord-001835-0s7ok4uw	2312	45	alterations	alteration	NNS
cord-001835-0s7ok4uw	2312	46	in	in	IN
cord-001835-0s7ok4uw	2312	47	the	the	DT
cord-001835-0s7ok4uw	2312	48	network	network	NN
cord-001835-0s7ok4uw	2312	49	of	of	IN
cord-001835-0s7ok4uw	2312	50	interactions	interaction	NNS
cord-001835-0s7ok4uw	2312	51	could	could	MD
cord-001835-0s7ok4uw	2312	52	be	be	VB
cord-001835-0s7ok4uw	2312	53	responsible	responsible	JJ
cord-001835-0s7ok4uw	2312	54	for	for	IN
cord-001835-0s7ok4uw	2312	55	the	the	DT
cord-001835-0s7ok4uw	2312	56	loss	loss	NN
cord-001835-0s7ok4uw	2312	57	of	of	IN
cord-001835-0s7ok4uw	2312	58	activity	activity	NN
cord-001835-0s7ok4uw	2312	59	.	.	.
cord-001835-0s7ok4uw	2313	1	However	however	RB
cord-001835-0s7ok4uw	2313	2	,	,	,
cord-001835-0s7ok4uw	2313	3	a	a	DT
cord-001835-0s7ok4uw	2313	4	change	change	NN
cord-001835-0s7ok4uw	2313	5	in	in	IN
cord-001835-0s7ok4uw	2313	6	the	the	DT
cord-001835-0s7ok4uw	2313	7	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2313	8	status	status	NN
cord-001835-0s7ok4uw	2313	9	of	of	IN
cord-001835-0s7ok4uw	2313	10	these	these	DT
cord-001835-0s7ok4uw	2313	11	mutants	mutant	NNS
cord-001835-0s7ok4uw	2313	12	was	be	VBD
cord-001835-0s7ok4uw	2313	13	also	also	RB
cord-001835-0s7ok4uw	2313	14	observed	observe	VBN
cord-001835-0s7ok4uw	2313	15	as	as	IN
cord-001835-0s7ok4uw	2313	16	compared	compare	VBN
cord-001835-0s7ok4uw	2313	17	to	to	IN
cord-001835-0s7ok4uw	2313	18	the	the	DT
cord-001835-0s7ok4uw	2313	19	wild	wild	JJ
cord-001835-0s7ok4uw	2313	20	-	-	HYPH
cord-001835-0s7ok4uw	2313	21	type	type	NN
cord-001835-0s7ok4uw	2313	22	Pro	Pro	NNP
cord-001835-0s7ok4uw	2313	23	,	,	,
cord-001835-0s7ok4uw	2313	24	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2313	25	that	that	IN
cord-001835-0s7ok4uw	2313	26	these	these	DT
cord-001835-0s7ok4uw	2313	27	residues	residue	NNS
cord-001835-0s7ok4uw	2313	28	are	be	VBP
cord-001835-0s7ok4uw	2313	29	important	important	JJ
cord-001835-0s7ok4uw	2313	30	for	for	IN
cord-001835-0s7ok4uw	2313	31	both	both	CC
cord-001835-0s7ok4uw	2313	32	the	the	DT
cord-001835-0s7ok4uw	2313	33	structural	structural	JJ
cord-001835-0s7ok4uw	2313	34	and	and	CC
cord-001835-0s7ok4uw	2313	35	functional	functional	JJ
cord-001835-0s7ok4uw	2313	36	integrity	integrity	NN
cord-001835-0s7ok4uw	2313	37	of	of	IN
cord-001835-0s7ok4uw	2313	38	Pro	Pro	NNP
cord-001835-0s7ok4uw	2313	39	and	and	CC
cord-001835-0s7ok4uw	2313	40	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2313	41	interaction	interaction	NN
cord-001835-0s7ok4uw	2313	42	with	with	IN
cord-001835-0s7ok4uw	2313	43	VPg	VPg	NNS
cord-001835-0s7ok4uw	2313	44	.	.	.
cord-001835-0s7ok4uw	2314	1	Thus	thus	RB
cord-001835-0s7ok4uw	2314	2	,	,	,
cord-001835-0s7ok4uw	2314	3	these	these	DT
cord-001835-0s7ok4uw	2314	4	results	result	NNS
cord-001835-0s7ok4uw	2314	5	provide	provide	VBP
cord-001835-0s7ok4uw	2314	6	a	a	DT
cord-001835-0s7ok4uw	2314	7	molecular	molecular	JJ
cord-001835-0s7ok4uw	2314	8	insight	insight	NN
cord-001835-0s7ok4uw	2314	9	into	into	IN
cord-001835-0s7ok4uw	2314	10	the	the	DT
cord-001835-0s7ok4uw	2314	11	VPg	VPg	NNS
cord-001835-0s7ok4uw	2314	12	-	-	HYPH
cord-001835-0s7ok4uw	2314	13	Pro	pro	JJ
cord-001835-0s7ok4uw	2314	14	interactions	interaction	NNS
cord-001835-0s7ok4uw	2314	15	and	and	CC
cord-001835-0s7ok4uw	2314	16	the	the	DT
cord-001835-0s7ok4uw	2314	17	modulation	modulation	NN
cord-001835-0s7ok4uw	2314	18	of	of	IN
cord-001835-0s7ok4uw	2314	19	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2314	20	structure	structure	NN
cord-001835-0s7ok4uw	2314	21	and	and	CC
cord-001835-0s7ok4uw	2314	22	function	function	NN
cord-001835-0s7ok4uw	2314	23	upon	upon	IN
cord-001835-0s7ok4uw	2314	24	mutation	mutation	NN
cord-001835-0s7ok4uw	2314	25	of	of	IN
cord-001835-0s7ok4uw	2314	26	residues	residue	NNS
cord-001835-0s7ok4uw	2314	27	that	that	WDT
cord-001835-0s7ok4uw	2314	28	are	be	VBP
cord-001835-0s7ok4uw	2314	29	part	part	NN
cord-001835-0s7ok4uw	2314	30	of	of	IN
cord-001835-0s7ok4uw	2314	31	the	the	DT
cord-001835-0s7ok4uw	2314	32	interaction	interaction	NN
cord-001835-0s7ok4uw	2314	33	interface	interface	NN
cord-001835-0s7ok4uw	2314	34	.	.	.
cord-001835-0s7ok4uw	2315	1	Transthyretin	Transthyretin	NNP
cord-001835-0s7ok4uw	2315	2	(	(	-LRB-
cord-001835-0s7ok4uw	2315	3	TTR	TTR	NNP
cord-001835-0s7ok4uw	2315	4	)	)	-RRB-
cord-001835-0s7ok4uw	2315	5	is	be	VBZ
cord-001835-0s7ok4uw	2315	6	one	one	CD
cord-001835-0s7ok4uw	2315	7	of	of	IN
cord-001835-0s7ok4uw	2315	8	many	many	JJ
cord-001835-0s7ok4uw	2315	9	proteins	protein	NNS
cord-001835-0s7ok4uw	2315	10	that	that	WDT
cord-001835-0s7ok4uw	2315	11	are	be	VBP
cord-001835-0s7ok4uw	2315	12	capable	capable	JJ
cord-001835-0s7ok4uw	2315	13	of	of	IN
cord-001835-0s7ok4uw	2315	14	forming	form	VBG
cord-001835-0s7ok4uw	2315	15	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2315	16	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2315	17	in	in	IN
cord-001835-0s7ok4uw	2315	18	vivo	vivo	NN
cord-001835-0s7ok4uw	2315	19	.	.	.
cord-001835-0s7ok4uw	2316	1	This	this	DT
cord-001835-0s7ok4uw	2316	2	protein	protein	NN
cord-001835-0s7ok4uw	2316	3	is	be	VBZ
cord-001835-0s7ok4uw	2316	4	associated	associate	VBN
cord-001835-0s7ok4uw	2316	5	with	with	IN
cord-001835-0s7ok4uw	2316	6	two	two	CD
cord-001835-0s7ok4uw	2316	7	distinct	distinct	JJ
cord-001835-0s7ok4uw	2316	8	amyloidosis	amyloidosis	NN
cord-001835-0s7ok4uw	2316	9	:	:	:
cord-001835-0s7ok4uw	2316	10	Familial	Familial	NNP
cord-001835-0s7ok4uw	2316	11	Cardiac	Cardiac	NNP
cord-001835-0s7ok4uw	2316	12	Amyloidosis	Amyloidosis	NNP
cord-001835-0s7ok4uw	2316	13	(	(	-LRB-
cord-001835-0s7ok4uw	2316	14	FCA	FCA	NNP
cord-001835-0s7ok4uw	2316	15	)	)	-RRB-
cord-001835-0s7ok4uw	2316	16	that	that	WDT
cord-001835-0s7ok4uw	2316	17	causes	cause	VBZ
cord-001835-0s7ok4uw	2316	18	a	a	DT
cord-001835-0s7ok4uw	2316	19	restrictive	restrictive	JJ
cord-001835-0s7ok4uw	2316	20	cardiomyopathy	cardiomyopathy	NN
cord-001835-0s7ok4uw	2316	21	and	and	CC
cord-001835-0s7ok4uw	2316	22	Familial	Familial	NNP
cord-001835-0s7ok4uw	2316	23	Amyloid	Amyloid	NNP
cord-001835-0s7ok4uw	2316	24	Polyneuropathy	Polyneuropathy	NNP
cord-001835-0s7ok4uw	2316	25	(	(	-LRB-
cord-001835-0s7ok4uw	2316	26	FAP	FAP	NNP
cord-001835-0s7ok4uw	2316	27	)	)	-RRB-
cord-001835-0s7ok4uw	2316	28	that	that	WDT
cord-001835-0s7ok4uw	2316	29	affect	affect	VBP
cord-001835-0s7ok4uw	2316	30	peripheral	peripheral	JJ
cord-001835-0s7ok4uw	2316	31	nerves	nerve	NNS
cord-001835-0s7ok4uw	2316	32	,	,	,
cord-001835-0s7ok4uw	2316	33	they	-PRON-	PRP
cord-001835-0s7ok4uw	2316	34	are	be	VBP
cord-001835-0s7ok4uw	2316	35	hereditary	hereditary	JJ
cord-001835-0s7ok4uw	2316	36	and	and	CC
cord-001835-0s7ok4uw	2316	37	caused	cause	VBN
cord-001835-0s7ok4uw	2316	38	by	by	IN
cord-001835-0s7ok4uw	2316	39	mutations	mutation	NNS
cord-001835-0s7ok4uw	2316	40	in	in	IN
cord-001835-0s7ok4uw	2316	41	the	the	DT
cord-001835-0s7ok4uw	2316	42	TTR	TTR	NNP
cord-001835-0s7ok4uw	2316	43	gene	gene	NN
cord-001835-0s7ok4uw	2316	44	.	.	.
cord-001835-0s7ok4uw	2317	1	The	the	DT
cord-001835-0s7ok4uw	2317	2	non	non	JJ
cord-001835-0s7ok4uw	2317	3	mutated	mutated	JJ
cord-001835-0s7ok4uw	2317	4	protein	protein	NN
cord-001835-0s7ok4uw	2317	5	can	can	MD
cord-001835-0s7ok4uw	2317	6	also	also	RB
cord-001835-0s7ok4uw	2317	7	aggregate	aggregate	VB
cord-001835-0s7ok4uw	2317	8	in	in	IN
cord-001835-0s7ok4uw	2317	9	cardiac	cardiac	JJ
cord-001835-0s7ok4uw	2317	10	tissue	tissue	NN
cord-001835-0s7ok4uw	2317	11	in	in	IN
cord-001835-0s7ok4uw	2317	12	advanced	advanced	JJ
cord-001835-0s7ok4uw	2317	13	age	age	NN
cord-001835-0s7ok4uw	2317	14	patients	patient	NNS
cord-001835-0s7ok4uw	2317	15	.	.	.
cord-001835-0s7ok4uw	2318	1	The	the	DT
cord-001835-0s7ok4uw	2318	2	diagnosis	diagnosis	NN
cord-001835-0s7ok4uw	2318	3	was	be	VBD
cord-001835-0s7ok4uw	2318	4	established	establish	VBN
cord-001835-0s7ok4uw	2318	5	at	at	IN
cord-001835-0s7ok4uw	2318	6	University	University	NNP
cord-001835-0s7ok4uw	2318	7	Hospital	Hospital	NNP
cord-001835-0s7ok4uw	2318	8	since	since	IN
cord-001835-0s7ok4uw	2318	9	2008	2008	CD
cord-001835-0s7ok4uw	2318	10	due	due	IN
cord-001835-0s7ok4uw	2318	11	to	to	IN
cord-001835-0s7ok4uw	2318	12	a	a	DT
cord-001835-0s7ok4uw	2318	13	collaborative	collaborative	NN
cord-001835-0s7ok4uw	2318	14	between	between	IN
cord-001835-0s7ok4uw	2318	15	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2318	16	group	group	NN
cord-001835-0s7ok4uw	2318	17	and	and	CC
cord-001835-0s7ok4uw	2318	18	the	the	DT
cord-001835-0s7ok4uw	2318	19	center	center	NN
cord-001835-0s7ok4uw	2318	20	of	of	IN
cord-001835-0s7ok4uw	2318	21	Amyloidosis	Amyloidosis	NNP
cord-001835-0s7ok4uw	2318	22	Antônio	Antônio	NNP
cord-001835-0s7ok4uw	2318	23	Rodrigues	Rodrigues	NNP
cord-001835-0s7ok4uw	2318	24	de	de	NNP
cord-001835-0s7ok4uw	2318	25	Mello	Mello	NNP
cord-001835-0s7ok4uw	2318	26	(	(	-LRB-
cord-001835-0s7ok4uw	2318	27	CEPARM	CEPARM	NNP
cord-001835-0s7ok4uw	2318	28	)	)	-RRB-
cord-001835-0s7ok4uw	2318	29	.	.	.
cord-001835-0s7ok4uw	2319	1	The	the	DT
cord-001835-0s7ok4uw	2319	2	only	only	JJ
cord-001835-0s7ok4uw	2319	3	mutation	mutation	NN
cord-001835-0s7ok4uw	2319	4	found	find	VBN
cord-001835-0s7ok4uw	2319	5	in	in	IN
cord-001835-0s7ok4uw	2319	6	Brazil	Brazil	NNP
cord-001835-0s7ok4uw	2319	7	was	be	VBD
cord-001835-0s7ok4uw	2319	8	V30	V30	NNP
cord-001835-0s7ok4uw	2319	9	M	M	NNP
cord-001835-0s7ok4uw	2319	10	in	in	IN
cord-001835-0s7ok4uw	2319	11	3	3	CD
cord-001835-0s7ok4uw	2319	12	patients	patient	NNS
cord-001835-0s7ok4uw	2319	13	diagnosed	diagnose	VBN
cord-001835-0s7ok4uw	2319	14	in	in	IN
cord-001835-0s7ok4uw	2319	15	France	France	NNP
cord-001835-0s7ok4uw	2319	16	.	.	.
cord-001835-0s7ok4uw	2320	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2320	2	group	group	NN
cord-001835-0s7ok4uw	2320	3	discovered	discover	VBD
cord-001835-0s7ok4uw	2320	4	5	5	CD
cord-001835-0s7ok4uw	2320	5	new	new	JJ
cord-001835-0s7ok4uw	2320	6	mutation	mutation	NN
cord-001835-0s7ok4uw	2320	7	not	not	RB
cord-001835-0s7ok4uw	2320	8	described	describe	VBN
cord-001835-0s7ok4uw	2320	9	in	in	IN
cord-001835-0s7ok4uw	2320	10	Brazil	Brazil	NNP
cord-001835-0s7ok4uw	2320	11	and	and	CC
cord-001835-0s7ok4uw	2320	12	a	a	DT
cord-001835-0s7ok4uw	2320	13	novel	novel	JJ
cord-001835-0s7ok4uw	2320	14	mutation	mutation	NN
cord-001835-0s7ok4uw	2320	15	not	not	RB
cord-001835-0s7ok4uw	2320	16	described	describe	VBN
cord-001835-0s7ok4uw	2320	17	yet	yet	RB
cord-001835-0s7ok4uw	2321	1	A19D.	A19D.	NNS
cord-001835-0s7ok4uw	2322	1	The	the	DT
cord-001835-0s7ok4uw	2322	2	diagnosed	diagnosed	JJ
cord-001835-0s7ok4uw	2322	3	patients	patient	NNS
cord-001835-0s7ok4uw	2322	4	are	be	VBP
cord-001835-0s7ok4uw	2322	5	registered	register	VBN
cord-001835-0s7ok4uw	2322	6	in	in	IN
cord-001835-0s7ok4uw	2322	7	Transthyretin	Transthyretin	NNP
cord-001835-0s7ok4uw	2322	8	Amyloidosis	Amyloidosis	NNP
cord-001835-0s7ok4uw	2322	9	Outcomes	Outcomes	NNPS
cord-001835-0s7ok4uw	2322	10	Survey	Survey	NNP
cord-001835-0s7ok4uw	2322	11	(	(	-LRB-
cord-001835-0s7ok4uw	2322	12	THAOS	THAOS	NNP
cord-001835-0s7ok4uw	2322	13	)	)	-RRB-
cord-001835-0s7ok4uw	2322	14	.	.	.
cord-001835-0s7ok4uw	2323	1	The	the	DT
cord-001835-0s7ok4uw	2323	2	novel	novel	JJ
cord-001835-0s7ok4uw	2323	3	mutation	mutation	NN
cord-001835-0s7ok4uw	2323	4	A19D	a19d	RB
cord-001835-0s7ok4uw	2323	5	causes	cause	VBZ
cord-001835-0s7ok4uw	2323	6	a	a	DT
cord-001835-0s7ok4uw	2323	7	severe	severe	JJ
cord-001835-0s7ok4uw	2323	8	restrictive	restrictive	JJ
cord-001835-0s7ok4uw	2323	9	cardiomyopathy	cardiomyopathy	NN
cord-001835-0s7ok4uw	2323	10	that	that	WDT
cord-001835-0s7ok4uw	2323	11	is	be	VBZ
cord-001835-0s7ok4uw	2323	12	certainly	certainly	RB
cord-001835-0s7ok4uw	2323	13	related	relate	VBN
cord-001835-0s7ok4uw	2323	14	to	to	IN
cord-001835-0s7ok4uw	2323	15	a	a	DT
cord-001835-0s7ok4uw	2323	16	higher	high	JJR
cord-001835-0s7ok4uw	2323	17	profile	profile	NN
cord-001835-0s7ok4uw	2323	18	of	of	IN
cord-001835-0s7ok4uw	2323	19	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2323	20	observed	observe	VBN
cord-001835-0s7ok4uw	2323	21	for	for	IN
cord-001835-0s7ok4uw	2323	22	this	this	DT
cord-001835-0s7ok4uw	2323	23	mutant	mutant	NN
cord-001835-0s7ok4uw	2323	24	if	if	IN
cord-001835-0s7ok4uw	2323	25	compared	compare	VBN
cord-001835-0s7ok4uw	2323	26	to	to	IN
cord-001835-0s7ok4uw	2323	27	others	other	NNS
cord-001835-0s7ok4uw	2323	28	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	2323	29	mutants	mutant	NNS
cord-001835-0s7ok4uw	2323	30	of	of	IN
cord-001835-0s7ok4uw	2323	31	TTR	TTR	NNP
cord-001835-0s7ok4uw	2323	32	.	.	.
cord-001835-0s7ok4uw	2324	1	Structural	structural	JJ
cord-001835-0s7ok4uw	2324	2	predictions	prediction	NNS
cord-001835-0s7ok4uw	2324	3	using	use	VBG
cord-001835-0s7ok4uw	2324	4	a	a	DT
cord-001835-0s7ok4uw	2324	5	bioinformatics	bioinformatics	NN
cord-001835-0s7ok4uw	2324	6	tool	tool	NN
cord-001835-0s7ok4uw	2324	7	called	call	VBN
cord-001835-0s7ok4uw	2324	8	FoldX	FoldX	NNP
cord-001835-0s7ok4uw	2324	9	showed	show	VBD
cord-001835-0s7ok4uw	2324	10	that	that	IN
cord-001835-0s7ok4uw	2324	11	the	the	DT
cord-001835-0s7ok4uw	2324	12	insertion	insertion	NN
cord-001835-0s7ok4uw	2324	13	of	of	IN
cord-001835-0s7ok4uw	2324	14	the	the	DT
cord-001835-0s7ok4uw	2324	15	mutation	mutation	NN
cord-001835-0s7ok4uw	2324	16	cause	cause	VB
cord-001835-0s7ok4uw	2324	17	a	a	DT
cord-001835-0s7ok4uw	2324	18	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	2324	19	clash	clash	NN
cord-001835-0s7ok4uw	2324	20	that	that	WDT
cord-001835-0s7ok4uw	2324	21	facilitates	facilitate	VBZ
cord-001835-0s7ok4uw	2324	22	the	the	DT
cord-001835-0s7ok4uw	2324	23	dissociation	dissociation	NN
cord-001835-0s7ok4uw	2324	24	and	and	CC
cord-001835-0s7ok4uw	2324	25	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2324	26	of	of	IN
cord-001835-0s7ok4uw	2324	27	protein	protein	NN
cord-001835-0s7ok4uw	2324	28	.	.	.
cord-001835-0s7ok4uw	2325	1	This	this	DT
cord-001835-0s7ok4uw	2325	2	mutant	mutant	NN
cord-001835-0s7ok4uw	2325	3	was	be	VBD
cord-001835-0s7ok4uw	2325	4	purified	purify	VBN
cord-001835-0s7ok4uw	2325	5	heterologously	heterologously	NNP
cord-001835-0s7ok4uw	2325	6	and	and	CC
cord-001835-0s7ok4uw	2325	7	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	2325	8	studies	study	NNS
cord-001835-0s7ok4uw	2325	9	revealed	reveal	VBD
cord-001835-0s7ok4uw	2325	10	that	that	IN
cord-001835-0s7ok4uw	2325	11	this	this	DT
cord-001835-0s7ok4uw	2325	12	protein	protein	NN
cord-001835-0s7ok4uw	2325	13	is	be	VBZ
cord-001835-0s7ok4uw	2325	14	a	a	DT
cord-001835-0s7ok4uw	2325	15	dimer	dimer	NN
cord-001835-0s7ok4uw	2325	16	and	and	CC
cord-001835-0s7ok4uw	2325	17	not	not	RB
cord-001835-0s7ok4uw	2325	18	a	a	DT
cord-001835-0s7ok4uw	2325	19	tetramer	tetramer	NN
cord-001835-0s7ok4uw	2325	20	as	as	IN
cord-001835-0s7ok4uw	2325	21	commonly	commonly	RB
cord-001835-0s7ok4uw	2325	22	the	the	DT
cord-001835-0s7ok4uw	2325	23	TTR	TTR	NNP
cord-001835-0s7ok4uw	2325	24	structure	structure	NN
cord-001835-0s7ok4uw	2325	25	.	.	.
cord-001835-0s7ok4uw	2326	1	The	the	DT
cord-001835-0s7ok4uw	2326	2	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	2326	3	structure	structure	NN
cord-001835-0s7ok4uw	2326	4	indicates	indicate	VBZ
cord-001835-0s7ok4uw	2326	5	that	that	IN
cord-001835-0s7ok4uw	2326	6	this	this	DT
cord-001835-0s7ok4uw	2326	7	mutant	mutant	NN
cord-001835-0s7ok4uw	2326	8	is	be	VBZ
cord-001835-0s7ok4uw	2326	9	structurally	structurally	RB
cord-001835-0s7ok4uw	2326	10	identical	identical	JJ
cord-001835-0s7ok4uw	2326	11	to	to	IN
cord-001835-0s7ok4uw	2326	12	wild	wild	JJ
cord-001835-0s7ok4uw	2326	13	type	type	NN
cord-001835-0s7ok4uw	2326	14	.	.	.
cord-001835-0s7ok4uw	2327	1	Biophysical	Biophysical	NNP
cord-001835-0s7ok4uw	2327	2	studies	study	NNS
cord-001835-0s7ok4uw	2327	3	revealed	reveal	VBD
cord-001835-0s7ok4uw	2327	4	that	that	IN
cord-001835-0s7ok4uw	2327	5	this	this	DT
cord-001835-0s7ok4uw	2327	6	protein	protein	NN
cord-001835-0s7ok4uw	2327	7	is	be	VBZ
cord-001835-0s7ok4uw	2327	8	a	a	DT
cord-001835-0s7ok4uw	2327	9	dimer	dimer	NN
cord-001835-0s7ok4uw	2327	10	and	and	CC
cord-001835-0s7ok4uw	2327	11	not	not	RB
cord-001835-0s7ok4uw	2327	12	a	a	DT
cord-001835-0s7ok4uw	2327	13	tetramer	tetramer	NN
cord-001835-0s7ok4uw	2327	14	as	as	IN
cord-001835-0s7ok4uw	2327	15	commonly	commonly	RB
cord-001835-0s7ok4uw	2327	16	the	the	DT
cord-001835-0s7ok4uw	2327	17	TTR	TTR	NNP
cord-001835-0s7ok4uw	2327	18	structure	structure	NN
cord-001835-0s7ok4uw	2327	19	.	.	.
cord-001835-0s7ok4uw	2328	1	The	the	DT
cord-001835-0s7ok4uw	2328	2	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	2328	3	stability	stability	NN
cord-001835-0s7ok4uw	2328	4	of	of	IN
cord-001835-0s7ok4uw	2328	5	A19d	A19d	NNPS
cord-001835-0s7ok4uw	2328	6	is	be	VBZ
cord-001835-0s7ok4uw	2328	7	lower	low	JJR
cord-001835-0s7ok4uw	2328	8	than	than	IN
cord-001835-0s7ok4uw	2328	9	the	the	DT
cord-001835-0s7ok4uw	2328	10	wild	wild	JJ
cord-001835-0s7ok4uw	2328	11	type	type	NN
cord-001835-0s7ok4uw	2328	12	TTR	TTR	NNP
cord-001835-0s7ok4uw	2328	13	.	.	.
cord-001835-0s7ok4uw	2329	1	The	the	DT
cord-001835-0s7ok4uw	2329	2	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2329	3	profile	profile	NN
cord-001835-0s7ok4uw	2329	4	showed	show	VBD
cord-001835-0s7ok4uw	2329	5	us	-PRON-	PRP
cord-001835-0s7ok4uw	2329	6	that	that	IN
cord-001835-0s7ok4uw	2329	7	this	this	DT
cord-001835-0s7ok4uw	2329	8	protein	protein	NN
cord-001835-0s7ok4uw	2329	9	can	can	MD
cord-001835-0s7ok4uw	2329	10	aggregate	aggregate	VB
cord-001835-0s7ok4uw	2329	11	in	in	IN
cord-001835-0s7ok4uw	2329	12	a	a	DT
cord-001835-0s7ok4uw	2329	13	higher	high	JJR
cord-001835-0s7ok4uw	2329	14	manner	manner	NN
cord-001835-0s7ok4uw	2329	15	and	and	CC
cord-001835-0s7ok4uw	2329	16	with	with	IN
cord-001835-0s7ok4uw	2329	17	a	a	DT
cord-001835-0s7ok4uw	2329	18	fast	fast	JJ
cord-001835-0s7ok4uw	2329	19	kinetic	kinetic	NN
cord-001835-0s7ok4uw	2329	20	to	to	IN
cord-001835-0s7ok4uw	2329	21	that	that	DT
cord-001835-0s7ok4uw	2329	22	observed	observe	VBN
cord-001835-0s7ok4uw	2329	23	for	for	IN
cord-001835-0s7ok4uw	2329	24	others	other	NNS
cord-001835-0s7ok4uw	2329	25	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	2329	26	mutants	mutant	NNS
cord-001835-0s7ok4uw	2329	27	of	of	IN
cord-001835-0s7ok4uw	2329	28	TTR	TTR	NNP
cord-001835-0s7ok4uw	2329	29	,	,	,
cord-001835-0s7ok4uw	2329	30	forming	form	VBG
cord-001835-0s7ok4uw	2329	31	fibers	fiber	NNS
cord-001835-0s7ok4uw	2329	32	in	in	IN
cord-001835-0s7ok4uw	2329	33	two	two	CD
cord-001835-0s7ok4uw	2329	34	hours	hour	NNS
cord-001835-0s7ok4uw	2329	35	of	of	IN
cord-001835-0s7ok4uw	2329	36	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2329	37	.	.	.
cord-001835-0s7ok4uw	2330	1	Heterotetramers	Heterotetramers	NNP
cord-001835-0s7ok4uw	2330	2	of	of	IN
cord-001835-0s7ok4uw	2330	3	A19D	A19D	NNP
cord-001835-0s7ok4uw	2330	4	and	and	CC
cord-001835-0s7ok4uw	2330	5	WT	WT	NNP
cord-001835-0s7ok4uw	2330	6	are	be	VBP
cord-001835-0s7ok4uw	2330	7	able	able	JJ
cord-001835-0s7ok4uw	2330	8	to	to	TO
cord-001835-0s7ok4uw	2330	9	aggregate	aggregate	VB
cord-001835-0s7ok4uw	2330	10	in	in	IN
cord-001835-0s7ok4uw	2330	11	the	the	DT
cord-001835-0s7ok4uw	2330	12	same	same	JJ
cord-001835-0s7ok4uw	2330	13	fiber	fiber	NN
cord-001835-0s7ok4uw	2330	14	structure	structure	NN
cord-001835-0s7ok4uw	2330	15	.	.	.
cord-001835-0s7ok4uw	2331	1	The	the	DT
cord-001835-0s7ok4uw	2331	2	analysis	analysis	NN
cord-001835-0s7ok4uw	2331	3	of	of	IN
cord-001835-0s7ok4uw	2331	4	interface	interface	NN
cord-001835-0s7ok4uw	2331	5	interaction	interaction	NN
cord-001835-0s7ok4uw	2331	6	of	of	IN
cord-001835-0s7ok4uw	2331	7	this	this	DT
cord-001835-0s7ok4uw	2331	8	mutant	mutant	NN
cord-001835-0s7ok4uw	2331	9	using	use	VBG
cord-001835-0s7ok4uw	2331	10	the	the	DT
cord-001835-0s7ok4uw	2331	11	PDBSum	PDBSum	NNS
cord-001835-0s7ok4uw	2331	12	showed	show	VBD
cord-001835-0s7ok4uw	2331	13	modifications	modification	NNS
cord-001835-0s7ok4uw	2331	14	in	in	IN
cord-001835-0s7ok4uw	2331	15	the	the	DT
cord-001835-0s7ok4uw	2331	16	profile	profile	NN
cord-001835-0s7ok4uw	2331	17	of	of	IN
cord-001835-0s7ok4uw	2331	18	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2331	19	bonds	bond	NNS
cord-001835-0s7ok4uw	2331	20	and	and	CC
cord-001835-0s7ok4uw	2331	21	non	non	JJ
cord-001835-0s7ok4uw	2331	22	bonded	bond	VBN
cord-001835-0s7ok4uw	2331	23	contacts	contact	NNS
cord-001835-0s7ok4uw	2331	24	.	.	.
cord-001835-0s7ok4uw	2332	1	In	in	IN
cord-001835-0s7ok4uw	2332	2	addition	addition	NN
cord-001835-0s7ok4uw	2332	3	the	the	DT
cord-001835-0s7ok4uw	2332	4	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2332	5	of	of	IN
cord-001835-0s7ok4uw	2332	6	A19D	A19D	NNP
cord-001835-0s7ok4uw	2332	7	are	be	VBP
cord-001835-0s7ok4uw	2332	8	toxic	toxic	JJ
cord-001835-0s7ok4uw	2332	9	for	for	IN
cord-001835-0s7ok4uw	2332	10	primary	primary	JJ
cord-001835-0s7ok4uw	2332	11	culture	culture	NN
cord-001835-0s7ok4uw	2332	12	of	of	IN
cord-001835-0s7ok4uw	2332	13	cardiomyocytes	cardiomyocyte	NNS
cord-001835-0s7ok4uw	2332	14	from	from	IN
cord-001835-0s7ok4uw	2332	15	murine	murine	JJ
cord-001835-0s7ok4uw	2332	16	heart	heart	NN
cord-001835-0s7ok4uw	2332	17	.	.	.
cord-001835-0s7ok4uw	2333	1	The	the	DT
cord-001835-0s7ok4uw	2333	2	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	2333	3	profile	profile	NN
cord-001835-0s7ok4uw	2333	4	displayed	display	VBN
cord-001835-0s7ok4uw	2333	5	by	by	IN
cord-001835-0s7ok4uw	2333	6	this	this	DT
cord-001835-0s7ok4uw	2333	7	new	new	JJ
cord-001835-0s7ok4uw	2333	8	mutant	mutant	NN
cord-001835-0s7ok4uw	2333	9	can	can	MD
cord-001835-0s7ok4uw	2333	10	be	be	VB
cord-001835-0s7ok4uw	2333	11	directly	directly	RB
cord-001835-0s7ok4uw	2333	12	correlated	correlate	VBN
cord-001835-0s7ok4uw	2333	13	with	with	IN
cord-001835-0s7ok4uw	2333	14	the	the	DT
cord-001835-0s7ok4uw	2333	15	aggressiveness	aggressiveness	NN
cord-001835-0s7ok4uw	2333	16	observed	observe	VBN
cord-001835-0s7ok4uw	2333	17	in	in	IN
cord-001835-0s7ok4uw	2333	18	the	the	DT
cord-001835-0s7ok4uw	2333	19	disease	disease	NN
cord-001835-0s7ok4uw	2333	20	developed	develop	VBN
cord-001835-0s7ok4uw	2333	21	by	by	IN
cord-001835-0s7ok4uw	2333	22	the	the	DT
cord-001835-0s7ok4uw	2333	23	identified	identify	VBN
cord-001835-0s7ok4uw	2333	24	patient	patient	NN
cord-001835-0s7ok4uw	2333	25	.	.	.
cord-001835-0s7ok4uw	2334	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	2334	2	the	the	DT
cord-001835-0s7ok4uw	2334	3	recent	recent	JJ
cord-001835-0s7ok4uw	2334	4	consolidation	consolidation	NN
cord-001835-0s7ok4uw	2334	5	of	of	IN
cord-001835-0s7ok4uw	2334	6	TTR	TTR	NNP
cord-001835-0s7ok4uw	2334	7	diagnosis	diagnosis	NN
cord-001835-0s7ok4uw	2334	8	in	in	IN
cord-001835-0s7ok4uw	2334	9	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2334	10	university	university	NN
cord-001835-0s7ok4uw	2334	11	hospital	hospital	NN
cord-001835-0s7ok4uw	2334	12	led	lead	VBD
cord-001835-0s7ok4uw	2334	13	to	to	IN
cord-001835-0s7ok4uw	2334	14	the	the	DT
cord-001835-0s7ok4uw	2334	15	identification	identification	NN
cord-001835-0s7ok4uw	2334	16	of	of	IN
cord-001835-0s7ok4uw	2334	17	the	the	DT
cord-001835-0s7ok4uw	2334	18	rare	rare	JJ
cord-001835-0s7ok4uw	2334	19	A19D	a19d	NN
cord-001835-0s7ok4uw	2334	20	variant	variant	NN
cord-001835-0s7ok4uw	2334	21	in	in	IN
cord-001835-0s7ok4uw	2334	22	a	a	DT
cord-001835-0s7ok4uw	2334	23	Brazilian	brazilian	JJ
cord-001835-0s7ok4uw	2334	24	patient	patient	NN
cord-001835-0s7ok4uw	2334	25	,	,	,
cord-001835-0s7ok4uw	2334	26	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2334	27	that	that	IN
cord-001835-0s7ok4uw	2334	28	other	other	JJ
cord-001835-0s7ok4uw	2334	29	new	new	JJ
cord-001835-0s7ok4uw	2334	30	,	,	,
cord-001835-0s7ok4uw	2334	31	uncharacterized	uncharacterized	JJ
cord-001835-0s7ok4uw	2334	32	mutants	mutant	NNS
cord-001835-0s7ok4uw	2334	33	could	could	MD
cord-001835-0s7ok4uw	2334	34	be	be	VB
cord-001835-0s7ok4uw	2334	35	identified	identify	VBN
cord-001835-0s7ok4uw	2334	36	in	in	IN
cord-001835-0s7ok4uw	2334	37	the	the	DT
cord-001835-0s7ok4uw	2334	38	coming	come	VBG
cord-001835-0s7ok4uw	2334	39	years	year	NNS
cord-001835-0s7ok4uw	2334	40	.	.	.
cord-001835-0s7ok4uw	2335	1	Multiple	multiple	JJ
cord-001835-0s7ok4uw	2335	2	cellular	cellular	JJ
cord-001835-0s7ok4uw	2335	3	proteins	protein	NNS
cord-001835-0s7ok4uw	2335	4	interact	interact	VBP
cord-001835-0s7ok4uw	2335	5	with	with	IN
cord-001835-0s7ok4uw	2335	6	LEDGF	LEDGF	NNP
cord-001835-0s7ok4uw	2335	7	/	/	SYM
cord-001835-0s7ok4uw	2335	8	p75	p75	NN
cord-001835-0s7ok4uw	2335	9	through	through	IN
cord-001835-0s7ok4uw	2335	10	a	a	DT
cord-001835-0s7ok4uw	2335	11	conserved	conserved	JJ
cord-001835-0s7ok4uw	2335	12	unstructured	unstructured	JJ
cord-001835-0s7ok4uw	2335	13	consensus	consensus	NN
cord-001835-0s7ok4uw	2335	14	motif	motif	NN
cord-001835-0s7ok4uw	2335	15	[	[	-LRB-
cord-001835-0s7ok4uw	2335	16	1	1	CD
cord-001835-0s7ok4uw	2335	17	]	]	-RRB-
cord-001835-0s7ok4uw	2335	18	.	.	.
cord-001835-0s7ok4uw	2336	1	The	the	DT
cord-001835-0s7ok4uw	2336	2	LEDGF	LEDGF	NNP
cord-001835-0s7ok4uw	2336	3	/	/	SYM
cord-001835-0s7ok4uw	2336	4	p75-MLL1-Menin	p75-MLL1-Menin	NNP
cord-001835-0s7ok4uw	2336	5	complex	complex	NN
cord-001835-0s7ok4uw	2336	6	was	be	VBD
cord-001835-0s7ok4uw	2336	7	structurally	structurally	RB
cord-001835-0s7ok4uw	2336	8	characterized	characterize	VBN
cord-001835-0s7ok4uw	2336	9	,	,	,
cord-001835-0s7ok4uw	2336	10	but	but	CC
cord-001835-0s7ok4uw	2336	11	only	only	RB
cord-001835-0s7ok4uw	2336	12	partially	partially	RB
cord-001835-0s7ok4uw	2336	13	[	[	-LRB-
cord-001835-0s7ok4uw	2336	14	2	2	CD
cord-001835-0s7ok4uw	2336	15	]	]	-RRB-
cord-001835-0s7ok4uw	2336	16	.	.	.
cord-001835-0s7ok4uw	2337	1	Using	use	VBG
cord-001835-0s7ok4uw	2337	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	2337	3	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2337	4	,	,	,
cord-001835-0s7ok4uw	2337	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2337	6	identified	identify	VBD
cord-001835-0s7ok4uw	2337	7	and	and	CC
cord-001835-0s7ok4uw	2337	8	mapped	map	VBD
cord-001835-0s7ok4uw	2337	9	a	a	DT
cord-001835-0s7ok4uw	2337	10	novel	novel	JJ
cord-001835-0s7ok4uw	2337	11	MLL1-LEDGF/	MLL1-LEDGF/	NNP
cord-001835-0s7ok4uw	2337	12	p75	p75	NN
cord-001835-0s7ok4uw	2337	13	interface	interface	NN
cord-001835-0s7ok4uw	2337	14	.	.	.
cord-001835-0s7ok4uw	2338	1	Colony	colony	NN
cord-001835-0s7ok4uw	2338	2	forming	form	VBG
cord-001835-0s7ok4uw	2338	3	assays	assay	NNS
cord-001835-0s7ok4uw	2338	4	in	in	IN
cord-001835-0s7ok4uw	2338	5	MLL1-AF91	MLL1-AF91	NNP
cord-001835-0s7ok4uw	2338	6	leukemic	leukemic	JJ
cord-001835-0s7ok4uw	2338	7	cells	cell	NNS
cord-001835-0s7ok4uw	2338	8	expressing	express	VBG
cord-001835-0s7ok4uw	2338	9	MLL1	MLL1	NNP
cord-001835-0s7ok4uw	2338	10	interactiondefective	interactiondefective	JJ
cord-001835-0s7ok4uw	2338	11	LEDGF	LEDGF	NNP
cord-001835-0s7ok4uw	2338	12	/	/	SYM
cord-001835-0s7ok4uw	2338	13	p75	p75	CD
cord-001835-0s7ok4uw	2338	14	mutants	mutant	NNS
cord-001835-0s7ok4uw	2338	15	revealed	reveal	VBD
cord-001835-0s7ok4uw	2338	16	that	that	IN
cord-001835-0s7ok4uw	2338	17	this	this	DT
cord-001835-0s7ok4uw	2338	18	additional	additional	JJ
cord-001835-0s7ok4uw	2338	19	interface	interface	NN
cord-001835-0s7ok4uw	2338	20	is	be	VBZ
cord-001835-0s7ok4uw	2338	21	essential	essential	JJ
cord-001835-0s7ok4uw	2338	22	for	for	IN
cord-001835-0s7ok4uw	2338	23	leukemic	leukemic	JJ
cord-001835-0s7ok4uw	2338	24	transformation	transformation	NN
cord-001835-0s7ok4uw	2338	25	.	.	.
cord-001835-0s7ok4uw	2339	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	2339	2	,	,	,
cord-001835-0s7ok4uw	2339	3	the	the	DT
cord-001835-0s7ok4uw	2339	4	newly	newly	RB
cord-001835-0s7ok4uw	2339	5	defined	define	VBN
cord-001835-0s7ok4uw	2339	6	interface	interface	NN
cord-001835-0s7ok4uw	2339	7	overlaps	overlap	VBZ
cord-001835-0s7ok4uw	2339	8	with	with	IN
cord-001835-0s7ok4uw	2339	9	the	the	DT
cord-001835-0s7ok4uw	2339	10	binding	binding	NN
cord-001835-0s7ok4uw	2339	11	site	site	NN
cord-001835-0s7ok4uw	2339	12	of	of	IN
cord-001835-0s7ok4uw	2339	13	known	know	VBN
cord-001835-0s7ok4uw	2339	14	LEDGF	LEDGF	NNP
cord-001835-0s7ok4uw	2339	15	/	/	SYM
cord-001835-0s7ok4uw	2339	16	p75	p75	NNP
cord-001835-0s7ok4uw	2339	17	interactor	interactor	NNP
cord-001835-0s7ok4uw	2339	18	,	,	,
cord-001835-0s7ok4uw	2339	19	the	the	DT
cord-001835-0s7ok4uw	2339	20	HIV	HIV	NNP
cord-001835-0s7ok4uw	2339	21	integrase	integrase	NN
cord-001835-0s7ok4uw	2339	22	[	[	-LRB-
cord-001835-0s7ok4uw	2339	23	1	1	CD
cord-001835-0s7ok4uw	2339	24	]	]	-RRB-
cord-001835-0s7ok4uw	2339	25	.	.	.
cord-001835-0s7ok4uw	2340	1	While	while	IN
cord-001835-0s7ok4uw	2340	2	the	the	DT
cord-001835-0s7ok4uw	2340	3	pathophysiological	pathophysiological	JJ
cord-001835-0s7ok4uw	2340	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	2340	5	of	of	IN
cord-001835-0s7ok4uw	2340	6	LEDGF	LEDGF	NNP
cord-001835-0s7ok4uw	2340	7	/	/	SYM
cord-001835-0s7ok4uw	2340	8	p75	p75	NNP
cord-001835-0s7ok4uw	2340	9	are	be	VBP
cord-001835-0s7ok4uw	2340	10	intensively	intensively	RB
cord-001835-0s7ok4uw	2340	11	studied	study	VBN
cord-001835-0s7ok4uw	2340	12	,	,	,
cord-001835-0s7ok4uw	2340	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2340	14	physiological	physiological	JJ
cord-001835-0s7ok4uw	2340	15	role	role	NN
cord-001835-0s7ok4uw	2340	16	remains	remain	VBZ
cord-001835-0s7ok4uw	2340	17	unclear	unclear	JJ
cord-001835-0s7ok4uw	2340	18	.	.	.
cord-001835-0s7ok4uw	2341	1	Since	since	IN
cord-001835-0s7ok4uw	2341	2	LEDGF	LEDGF	NNP
cord-001835-0s7ok4uw	2341	3	/	/	SYM
cord-001835-0s7ok4uw	2341	4	p75	p75	NNP
cord-001835-0s7ok4uw	2341	5	contributes	contribute	VBZ
cord-001835-0s7ok4uw	2341	6	to	to	IN
cord-001835-0s7ok4uw	2341	7	HIV	HIV	NNP
cord-001835-0s7ok4uw	2341	8	integration	integration	NN
cord-001835-0s7ok4uw	2341	9	and	and	CC
cord-001835-0s7ok4uw	2341	10	leukemic	leukemic	JJ
cord-001835-0s7ok4uw	2341	11	transformation	transformation	NN
cord-001835-0s7ok4uw	2341	12	and	and	CC
cord-001835-0s7ok4uw	2341	13	has	have	VBZ
cord-001835-0s7ok4uw	2341	14	become	become	VBN
cord-001835-0s7ok4uw	2341	15	a	a	DT
cord-001835-0s7ok4uw	2341	16	new	new	JJ
cord-001835-0s7ok4uw	2341	17	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	2341	18	target	target	NN
cord-001835-0s7ok4uw	2341	19	for	for	IN
cord-001835-0s7ok4uw	2341	20	drug	drug	NN
cord-001835-0s7ok4uw	2341	21	development	development	NN
cord-001835-0s7ok4uw	2341	22	,	,	,
cord-001835-0s7ok4uw	2341	23	it	-PRON-	PRP
cord-001835-0s7ok4uw	2341	24	is	be	VBZ
cord-001835-0s7ok4uw	2341	25	crucial	crucial	JJ
cord-001835-0s7ok4uw	2341	26	to	to	TO
cord-001835-0s7ok4uw	2341	27	study	study	VB
cord-001835-0s7ok4uw	2341	28	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2341	29	physiological	physiological	JJ
cord-001835-0s7ok4uw	2341	30	interactions	interaction	NNS
cord-001835-0s7ok4uw	2341	31	.	.	.
cord-001835-0s7ok4uw	2342	1	In	in	IN
cord-001835-0s7ok4uw	2342	2	addition	addition	NN
cord-001835-0s7ok4uw	2342	3	to	to	IN
cord-001835-0s7ok4uw	2342	4	HIV	HIV	NNP
cord-001835-0s7ok4uw	2342	5	IN	IN	NNP
cord-001835-0s7ok4uw	2342	6	and	and	CC
cord-001835-0s7ok4uw	2342	7	MLL1-Menin	MLL1-Menin	NNP
cord-001835-0s7ok4uw	2342	8	,	,	,
cord-001835-0s7ok4uw	2342	9	the	the	DT
cord-001835-0s7ok4uw	2342	10	LEDGF	LEDGF	NNP
cord-001835-0s7ok4uw	2342	11	/	/	SYM
cord-001835-0s7ok4uw	2342	12	p75	p75	NN
cord-001835-0s7ok4uw	2342	13	integrase	integrase	NN
cord-001835-0s7ok4uw	2342	14	binding	bind	VBG
cord-001835-0s7ok4uw	2342	15	domain	domain	NN
cord-001835-0s7ok4uw	2342	16	(	(	-LRB-
cord-001835-0s7ok4uw	2342	17	IBD	IBD	NNP
cord-001835-0s7ok4uw	2342	18	)	)	-RRB-
cord-001835-0s7ok4uw	2342	19	also	also	RB
cord-001835-0s7ok4uw	2342	20	interacts	interact	VBZ
cord-001835-0s7ok4uw	2342	21	with	with	IN
cord-001835-0s7ok4uw	2342	22	several	several	JJ
cord-001835-0s7ok4uw	2342	23	other	other	JJ
cord-001835-0s7ok4uw	2342	24	proteins	protein	NNS
cord-001835-0s7ok4uw	2342	25	[	[	-LRB-
cord-001835-0s7ok4uw	2342	26	3	3	CD
cord-001835-0s7ok4uw	2342	27	,	,	,
cord-001835-0s7ok4uw	2342	28	4	4	CD
cord-001835-0s7ok4uw	2342	29	]	]	-RRB-
cord-001835-0s7ok4uw	2342	30	.	.	.
cord-001835-0s7ok4uw	2343	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2343	2	recent	recent	JJ
cord-001835-0s7ok4uw	2343	3	data	datum	NNS
cord-001835-0s7ok4uw	2343	4	(	(	-LRB-
cord-001835-0s7ok4uw	2343	5	manuscript	manuscript	NN
cord-001835-0s7ok4uw	2343	6	accepted	accept	VBD
cord-001835-0s7ok4uw	2343	7	in	in	IN
cord-001835-0s7ok4uw	2343	8	Nat	Nat	NNP
cord-001835-0s7ok4uw	2343	9	.	.	.
cord-001835-0s7ok4uw	2344	1	Commun	Commun	NNP
cord-001835-0s7ok4uw	2344	2	.	.	.
cord-001835-0s7ok4uw	2344	3	)	)	-RRB-
cord-001835-0s7ok4uw	2344	4	revealed	reveal	VBD
cord-001835-0s7ok4uw	2344	5	structural	structural	JJ
cord-001835-0s7ok4uw	2344	6	details	detail	NNS
cord-001835-0s7ok4uw	2344	7	of	of	IN
cord-001835-0s7ok4uw	2344	8	LEDGF	LEDGF	NNP
cord-001835-0s7ok4uw	2344	9	/	/	SYM
cord-001835-0s7ok4uw	2344	10	p75	p75	NN
cord-001835-0s7ok4uw	2344	11	interactions	interaction	NNS
cord-001835-0s7ok4uw	2344	12	with	with	IN
cord-001835-0s7ok4uw	2344	13	physiological	physiological	JJ
cord-001835-0s7ok4uw	2344	14	binding	bind	VBG
cord-001835-0s7ok4uw	2344	15	partners	partner	NNS
cord-001835-0s7ok4uw	2344	16	.	.	.
cord-001835-0s7ok4uw	2345	1	The	the	DT
cord-001835-0s7ok4uw	2345	2	interaction	interaction	NN
cord-001835-0s7ok4uw	2345	3	with	with	IN
cord-001835-0s7ok4uw	2345	4	the	the	DT
cord-001835-0s7ok4uw	2345	5	LEDGF	LEDGF	NNP
cord-001835-0s7ok4uw	2345	6	/	/	SYM
cord-001835-0s7ok4uw	2345	7	p75	p75	CD
cord-001835-0s7ok4uw	2345	8	IBD	IBD	NNP
cord-001835-0s7ok4uw	2345	9	is	be	VBZ
cord-001835-0s7ok4uw	2345	10	maintained	maintain	VBN
cord-001835-0s7ok4uw	2345	11	by	by	IN
cord-001835-0s7ok4uw	2345	12	an	an	DT
cord-001835-0s7ok4uw	2345	13	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2345	14	disordered	disordered	JJ
cord-001835-0s7ok4uw	2345	15	IBD	IBD	NNP
cord-001835-0s7ok4uw	2345	16	-	-	HYPH
cord-001835-0s7ok4uw	2345	17	binding	bind	VBG
cord-001835-0s7ok4uw	2345	18	motif	motif	NN
cord-001835-0s7ok4uw	2345	19	(	(	-LRB-
cord-001835-0s7ok4uw	2345	20	IBM	IBM	NNP
cord-001835-0s7ok4uw	2345	21	)	)	-RRB-
cord-001835-0s7ok4uw	2345	22	common	common	JJ
cord-001835-0s7ok4uw	2345	23	to	to	IN
cord-001835-0s7ok4uw	2345	24	all	all	DT
cord-001835-0s7ok4uw	2345	25	known	know	VBN
cord-001835-0s7ok4uw	2345	26	cellular	cellular	JJ
cord-001835-0s7ok4uw	2345	27	partners	partner	NNS
cord-001835-0s7ok4uw	2345	28	.	.	.
cord-001835-0s7ok4uw	2346	1	Based	base	VBN
cord-001835-0s7ok4uw	2346	2	on	on	IN
cord-001835-0s7ok4uw	2346	3	the	the	DT
cord-001835-0s7ok4uw	2346	4	knowledge	knowledge	NN
cord-001835-0s7ok4uw	2346	5	of	of	IN
cord-001835-0s7ok4uw	2346	6	this	this	DT
cord-001835-0s7ok4uw	2346	7	motif	motif	NN
cord-001835-0s7ok4uw	2346	8	,	,	,
cord-001835-0s7ok4uw	2346	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	2346	10	identified	identify	VBD
cord-001835-0s7ok4uw	2346	11	and	and	CC
cord-001835-0s7ok4uw	2346	12	validated	validate	VBD
cord-001835-0s7ok4uw	2346	13	IWS1	IWS1	NNP
cord-001835-0s7ok4uw	2346	14	as	as	IN
cord-001835-0s7ok4uw	2346	15	a	a	DT
cord-001835-0s7ok4uw	2346	16	novel	novel	JJ
cord-001835-0s7ok4uw	2346	17	LEDGF	LEDGF	NNP
cord-001835-0s7ok4uw	2346	18	/	/	SYM
cord-001835-0s7ok4uw	2346	19	p75	p75	NN
cord-001835-0s7ok4uw	2346	20	interaction	interaction	NN
cord-001835-0s7ok4uw	2346	21	partner	partner	NN
cord-001835-0s7ok4uw	2346	22	.	.	.
cord-001835-0s7ok4uw	2347	1	Naturally	naturally	RB
cord-001835-0s7ok4uw	2347	2	occurring	occur	VBG
cord-001835-0s7ok4uw	2347	3	single	single	JJ
cord-001835-0s7ok4uw	2347	4	mutants	mutant	NNS
cord-001835-0s7ok4uw	2347	5	,	,	,
cord-001835-0s7ok4uw	2347	6	I56	I56	NNP
cord-001835-0s7ok4uw	2347	7	T	T	NNP
cord-001835-0s7ok4uw	2347	8	,	,	,
cord-001835-0s7ok4uw	2347	9	F57I	F57I	NNS
cord-001835-0s7ok4uw	2347	10	,	,	,
cord-001835-0s7ok4uw	2347	11	W64R	W64R	NNPS
cord-001835-0s7ok4uw	2347	12	and	and	CC
cord-001835-0s7ok4uw	2347	13	D67H	D67H	NNS
cord-001835-0s7ok4uw	2347	14	of	of	IN
cord-001835-0s7ok4uw	2347	15	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	2347	16	in	in	IN
cord-001835-0s7ok4uw	2347	17	human	human	NN
cord-001835-0s7ok4uw	2347	18	,	,	,
cord-001835-0s7ok4uw	2347	19	have	have	VBP
cord-001835-0s7ok4uw	2347	20	been	be	VBN
cord-001835-0s7ok4uw	2347	21	known	know	VBN
cord-001835-0s7ok4uw	2347	22	to	to	TO
cord-001835-0s7ok4uw	2347	23	form	form	VB
cord-001835-0s7ok4uw	2347	24	abnormal	abnormal	JJ
cord-001835-0s7ok4uw	2347	25	protein	protein	NN
cord-001835-0s7ok4uw	2347	26	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	2347	27	(	(	-LRB-
cord-001835-0s7ok4uw	2347	28	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2347	29	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2347	30	)	)	-RRB-
cord-001835-0s7ok4uw	2347	31	and	and	CC
cord-001835-0s7ok4uw	2347	32	to	to	TO
cord-001835-0s7ok4uw	2347	33	accumulate	accumulate	VB
cord-001835-0s7ok4uw	2347	34	in	in	IN
cord-001835-0s7ok4uw	2347	35	several	several	JJ
cord-001835-0s7ok4uw	2347	36	organs	organ	NNS
cord-001835-0s7ok4uw	2347	37	,	,	,
cord-001835-0s7ok4uw	2347	38	including	include	VBG
cord-001835-0s7ok4uw	2347	39	liver	liver	NN
cord-001835-0s7ok4uw	2347	40	,	,	,
cord-001835-0s7ok4uw	2347	41	spleen	spleen	NN
cord-001835-0s7ok4uw	2347	42	and	and	CC
cord-001835-0s7ok4uw	2347	43	kidney	kidney	NN
cord-001835-0s7ok4uw	2347	44	,	,	,
cord-001835-0s7ok4uw	2347	45	resulting	result	VBG
cord-001835-0s7ok4uw	2347	46	in	in	IN
cord-001835-0s7ok4uw	2347	47	familial	familial	JJ
cord-001835-0s7ok4uw	2347	48	systemic	systemic	JJ
cord-001835-0s7ok4uw	2347	49	amyloidosis	amyloidosis	NN
cord-001835-0s7ok4uw	2347	50	.	.	.
cord-001835-0s7ok4uw	2348	1	These	these	DT
cord-001835-0s7ok4uw	2348	2	human	human	JJ
cord-001835-0s7ok4uw	2348	3	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	2348	4	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	2348	5	variants	variant	NNS
cord-001835-0s7ok4uw	2348	6	are	be	VBP
cord-001835-0s7ok4uw	2348	7	considered	consider	VBN
cord-001835-0s7ok4uw	2348	8	to	to	TO
cord-001835-0s7ok4uw	2348	9	raise	raise	VB
cord-001835-0s7ok4uw	2348	10	subtle	subtle	JJ
cord-001835-0s7ok4uw	2348	11	conformational	conformational	JJ
cord-001835-0s7ok4uw	2348	12	changes	change	NNS
cord-001835-0s7ok4uw	2348	13	compared	compare	VBN
cord-001835-0s7ok4uw	2348	14	to	to	IN
cord-001835-0s7ok4uw	2348	15	the	the	DT
cord-001835-0s7ok4uw	2348	16	wild	wild	JJ
cord-001835-0s7ok4uw	2348	17	type	type	NN
cord-001835-0s7ok4uw	2348	18	.	.	.
cord-001835-0s7ok4uw	2349	1	Here	here	RB
cord-001835-0s7ok4uw	2349	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2349	3	examined	examine	VBD
cord-001835-0s7ok4uw	2349	4	the	the	DT
cord-001835-0s7ok4uw	2349	5	effects	effect	NNS
cord-001835-0s7ok4uw	2349	6	of	of	IN
cord-001835-0s7ok4uw	2349	7	the	the	DT
cord-001835-0s7ok4uw	2349	8	aberrant	aberrant	JJ
cord-001835-0s7ok4uw	2349	9	mutant	mutant	NN
cord-001835-0s7ok4uw	2349	10	lysozymes	lysozyme	NNS
cord-001835-0s7ok4uw	2349	11	I56	I56	NNP
cord-001835-0s7ok4uw	2349	12	T	T	NNP
cord-001835-0s7ok4uw	2349	13	,	,	,
cord-001835-0s7ok4uw	2349	14	F57I	F57I	NNS
cord-001835-0s7ok4uw	2349	15	,	,	,
cord-001835-0s7ok4uw	2349	16	W64R	W64R	NNPS
cord-001835-0s7ok4uw	2349	17	and	and	CC
cord-001835-0s7ok4uw	2349	18	D67H	D67H	NNS
cord-001835-0s7ok4uw	2349	19	,	,	,
cord-001835-0s7ok4uw	2349	20	each	each	DT
cord-001835-0s7ok4uw	2349	21	of	of	IN
cord-001835-0s7ok4uw	2349	22	which	which	WDT
cord-001835-0s7ok4uw	2349	23	possesses	possess	VBZ
cord-001835-0s7ok4uw	2349	24	a	a	DT
cord-001835-0s7ok4uw	2349	25	point	point	NN
cord-001835-0s7ok4uw	2349	26	mutation	mutation	NN
cord-001835-0s7ok4uw	2349	27	in	in	IN
cord-001835-0s7ok4uw	2349	28	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2349	29	molecule	molecule	NN
cord-001835-0s7ok4uw	2349	30	,	,	,
cord-001835-0s7ok4uw	2349	31	on	on	IN
cord-001835-0s7ok4uw	2349	32	a	a	DT
cord-001835-0s7ok4uw	2349	33	cultured	cultured	JJ
cord-001835-0s7ok4uw	2349	34	human	human	JJ
cord-001835-0s7ok4uw	2349	35	cell	cell	NN
cord-001835-0s7ok4uw	2349	36	line	line	NN
cord-001835-0s7ok4uw	2349	37	,	,	,
cord-001835-0s7ok4uw	2349	38	HEK293	HEK293	NNP
cord-001835-0s7ok4uw	2349	39	,	,	,
cord-001835-0s7ok4uw	2349	40	in	in	IN
cord-001835-0s7ok4uw	2349	41	which	which	WDT
cord-001835-0s7ok4uw	2349	42	the	the	DT
cord-001835-0s7ok4uw	2349	43	genes	gene	NNS
cord-001835-0s7ok4uw	2349	44	were	be	VBD
cord-001835-0s7ok4uw	2349	45	individually	individually	RB
cord-001835-0s7ok4uw	2349	46	integrated	integrate	VBN
cord-001835-0s7ok4uw	2349	47	and	and	CC
cord-001835-0s7ok4uw	2349	48	overexpressed	overexpresse	VBN
cord-001835-0s7ok4uw	2349	49	.	.	.
cord-001835-0s7ok4uw	2350	1	Western	western	JJ
cord-001835-0s7ok4uw	2350	2	blot	blot	NN
cord-001835-0s7ok4uw	2350	3	analyses	analysis	NNS
cord-001835-0s7ok4uw	2350	4	showed	show	VBD
cord-001835-0s7ok4uw	2350	5	lesser	less	JJR
cord-001835-0s7ok4uw	2350	6	amounts	amount	NNS
cord-001835-0s7ok4uw	2350	7	of	of	IN
cord-001835-0s7ok4uw	2350	8	these	these	DT
cord-001835-0s7ok4uw	2350	9	variant	variant	JJ
cord-001835-0s7ok4uw	2350	10	proteins	protein	NNS
cord-001835-0s7ok4uw	2350	11	in	in	IN
cord-001835-0s7ok4uw	2350	12	the	the	DT
cord-001835-0s7ok4uw	2350	13	medium	medium	NN
cord-001835-0s7ok4uw	2350	14	compared	compare	VBN
cord-001835-0s7ok4uw	2350	15	to	to	IN
cord-001835-0s7ok4uw	2350	16	the	the	DT
cord-001835-0s7ok4uw	2350	17	wild	wild	JJ
cord-001835-0s7ok4uw	2350	18	type	type	NN
cord-001835-0s7ok4uw	2350	19	,	,	,
cord-001835-0s7ok4uw	2350	20	but	but	CC
cord-001835-0s7ok4uw	2350	21	they	-PRON-	PRP
cord-001835-0s7ok4uw	2350	22	were	be	VBD
cord-001835-0s7ok4uw	2350	23	abundant	abundant	JJ
cord-001835-0s7ok4uw	2350	24	in	in	IN
cord-001835-0s7ok4uw	2350	25	the	the	DT
cord-001835-0s7ok4uw	2350	26	cell	cell	NN
cord-001835-0s7ok4uw	2350	27	pellets	pellet	NNS
cord-001835-0s7ok4uw	2350	28	,	,	,
cord-001835-0s7ok4uw	2350	29	indicating	indicate	VBG
cord-001835-0s7ok4uw	2350	30	that	that	IN
cord-001835-0s7ok4uw	2350	31	the	the	DT
cord-001835-0s7ok4uw	2350	32	modified	modify	VBN
cord-001835-0s7ok4uw	2350	33	lysozyme	lysozyme	NN
cord-001835-0s7ok4uw	2350	34	proteins	protein	NNS
cord-001835-0s7ok4uw	2350	35	were	be	VBD
cord-001835-0s7ok4uw	2350	36	scarcely	scarcely	RB
cord-001835-0s7ok4uw	2350	37	secreted	secrete	VBN
cord-001835-0s7ok4uw	2350	38	into	into	IN
cord-001835-0s7ok4uw	2350	39	the	the	DT
cord-001835-0s7ok4uw	2350	40	medium	medium	NN
cord-001835-0s7ok4uw	2350	41	but	but	CC
cord-001835-0s7ok4uw	2350	42	were	be	VBD
cord-001835-0s7ok4uw	2350	43	retained	retain	VBN
cord-001835-0s7ok4uw	2350	44	in	in	IN
cord-001835-0s7ok4uw	2350	45	the	the	DT
cord-001835-0s7ok4uw	2350	46	cells	cell	NNS
cord-001835-0s7ok4uw	2350	47	.	.	.
cord-001835-0s7ok4uw	2351	1	Immunocytochemistry	Immunocytochemistry	NNP
cord-001835-0s7ok4uw	2351	2	revealed	reveal	VBD
cord-001835-0s7ok4uw	2351	3	that	that	IN
cord-001835-0s7ok4uw	2351	4	these	these	DT
cord-001835-0s7ok4uw	2351	5	proteins	protein	NNS
cord-001835-0s7ok4uw	2351	6	resided	reside	VBD
cord-001835-0s7ok4uw	2351	7	in	in	IN
cord-001835-0s7ok4uw	2351	8	restricted	restricted	JJ
cord-001835-0s7ok4uw	2351	9	regions	region	NNS
cord-001835-0s7ok4uw	2351	10	which	which	WDT
cord-001835-0s7ok4uw	2351	11	were	be	VBD
cord-001835-0s7ok4uw	2351	12	stained	stain	VBN
cord-001835-0s7ok4uw	2351	13	by	by	IN
cord-001835-0s7ok4uw	2351	14	an	an	DT
cord-001835-0s7ok4uw	2351	15	endoplasmic	endoplasmic	NN
cord-001835-0s7ok4uw	2351	16	reticulum	reticulum	NN
cord-001835-0s7ok4uw	2351	17	(	(	-LRB-
cord-001835-0s7ok4uw	2351	18	ER	er	NN
cord-001835-0s7ok4uw	2351	19	)	)	-RRB-
cord-001835-0s7ok4uw	2351	20	marker	marker	NN
cord-001835-0s7ok4uw	2351	21	.	.	.
cord-001835-0s7ok4uw	2352	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	2352	2	,	,	,
cord-001835-0s7ok4uw	2352	3	the	the	DT
cord-001835-0s7ok4uw	2352	4	overexpression	overexpression	NN
cord-001835-0s7ok4uw	2352	5	of	of	IN
cord-001835-0s7ok4uw	2352	6	the	the	DT
cord-001835-0s7ok4uw	2352	7	mutant	mutant	JJ
cord-001835-0s7ok4uw	2352	8	lysozymes	lysozyme	NNS
cord-001835-0s7ok4uw	2352	9	were	be	VBD
cord-001835-0s7ok4uw	2352	10	accompanied	accompany	VBN
cord-001835-0s7ok4uw	2352	11	by	by	IN
cord-001835-0s7ok4uw	2352	12	marked	marked	JJ
cord-001835-0s7ok4uw	2352	13	increases	increase	NNS
cord-001835-0s7ok4uw	2352	14	in	in	IN
cord-001835-0s7ok4uw	2352	15	XBP1s	XBP1s	NNP
cord-001835-0s7ok4uw	2352	16	and	and	CC
cord-001835-0s7ok4uw	2352	17	GRP78	GRP78	NNP
cord-001835-0s7ok4uw	2352	18	/	/	SYM
cord-001835-0s7ok4uw	2352	19	BiP	BiP	NNP
cord-001835-0s7ok4uw	2352	20	,	,	,
cord-001835-0s7ok4uw	2352	21	which	which	WDT
cord-001835-0s7ok4uw	2352	22	are	be	VBP
cord-001835-0s7ok4uw	2352	23	downstream	downstream	JJ
cord-001835-0s7ok4uw	2352	24	agents	agent	NNS
cord-001835-0s7ok4uw	2352	25	of	of	IN
cord-001835-0s7ok4uw	2352	26	the	the	DT
cord-001835-0s7ok4uw	2352	27	IRE1	IRE1	NNP
cord-001835-0s7ok4uw	2352	28	_	_	NNP
cord-001835-0s7ok4uw	2352	29	signaling	signal	VBG
cord-001835-0s7ok4uw	2352	30	pathway	pathway	NN
cord-001835-0s7ok4uw	2352	31	responding	respond	VBG
cord-001835-0s7ok4uw	2352	32	to	to	IN
cord-001835-0s7ok4uw	2352	33	the	the	DT
cord-001835-0s7ok4uw	2352	34	unfolded	unfold	VBN
cord-001835-0s7ok4uw	2352	35	protein	protein	NN
cord-001835-0s7ok4uw	2352	36	response	response	NN
cord-001835-0s7ok4uw	2352	37	(	(	-LRB-
cord-001835-0s7ok4uw	2352	38	UPR	UPR	NNP
cord-001835-0s7ok4uw	2352	39	)	)	-RRB-
cord-001835-0s7ok4uw	2352	40	upon	upon	IN
cord-001835-0s7ok4uw	2352	41	ER	ER	NNP
cord-001835-0s7ok4uw	2352	42	stress	stress	NN
cord-001835-0s7ok4uw	2352	43	.	.	.
cord-001835-0s7ok4uw	2353	1	RNAi	RNAi	NNP
cord-001835-0s7ok4uw	2353	2	for	for	IN
cord-001835-0s7ok4uw	2353	3	the	the	DT
cord-001835-0s7ok4uw	2353	4	mutant	mutant	JJ
cord-001835-0s7ok4uw	2353	5	lysozymes	lysozyme	NNS
cord-001835-0s7ok4uw	2353	6	'	'	POS
cord-001835-0s7ok4uw	2353	7	expression	expression	NN
cord-001835-0s7ok4uw	2353	8	greatly	greatly	RB
cord-001835-0s7ok4uw	2353	9	suppressed	suppress	VBD
cord-001835-0s7ok4uw	2353	10	the	the	DT
cord-001835-0s7ok4uw	2353	11	increases	increase	NNS
cord-001835-0s7ok4uw	2353	12	of	of	IN
cord-001835-0s7ok4uw	2353	13	these	these	DT
cord-001835-0s7ok4uw	2353	14	agents	agent	NNS
cord-001835-0s7ok4uw	2353	15	.	.	.
cord-001835-0s7ok4uw	2354	1	Next	next	RB
cord-001835-0s7ok4uw	2354	2	,	,	,
cord-001835-0s7ok4uw	2354	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2354	4	addressed	address	VBD
cord-001835-0s7ok4uw	2354	5	the	the	DT
cord-001835-0s7ok4uw	2354	6	interaction	interaction	NN
cord-001835-0s7ok4uw	2354	7	between	between	IN
cord-001835-0s7ok4uw	2354	8	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	2354	9	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	2354	10	and	and	CC
cord-001835-0s7ok4uw	2354	11	GRP78	GRP78	NNP
cord-001835-0s7ok4uw	2354	12	/	/	SYM
cord-001835-0s7ok4uw	2354	13	BiP	BiP	NNP
cord-001835-0s7ok4uw	2354	14	as	as	IN
cord-001835-0s7ok4uw	2354	15	the	the	DT
cord-001835-0s7ok4uw	2354	16	former	former	JJ
cord-001835-0s7ok4uw	2354	17	proteins	protein	NNS
cord-001835-0s7ok4uw	2354	18	were	be	VBD
cord-001835-0s7ok4uw	2354	19	obtained	obtain	VBN
cord-001835-0s7ok4uw	2354	20	by	by	IN
cord-001835-0s7ok4uw	2354	21	immunoprecipitation	immunoprecipitation	NN
cord-001835-0s7ok4uw	2354	22	with	with	IN
cord-001835-0s7ok4uw	2354	23	the	the	DT
cord-001835-0s7ok4uw	2354	24	latter	latter	JJ
cord-001835-0s7ok4uw	2354	25	protein	protein	NN
cord-001835-0s7ok4uw	2354	26	as	as	RB
cord-001835-0s7ok4uw	2354	27	well	well	RB
cord-001835-0s7ok4uw	2354	28	as	as	IN
cord-001835-0s7ok4uw	2354	29	colocalization	colocalization	NN
cord-001835-0s7ok4uw	2354	30	of	of	IN
cord-001835-0s7ok4uw	2354	31	both	both	DT
cord-001835-0s7ok4uw	2354	32	proteins	protein	NNS
cord-001835-0s7ok4uw	2354	33	in	in	IN
cord-001835-0s7ok4uw	2354	34	the	the	DT
cord-001835-0s7ok4uw	2354	35	ER	er	NN
cord-001835-0s7ok4uw	2354	36	.	.	.
cord-001835-0s7ok4uw	2355	1	Lysozyme	Lysozyme	NNP
cord-001835-0s7ok4uw	2355	2	composes	compose	VBZ
cord-001835-0s7ok4uw	2355	3	of	of	IN
cord-001835-0s7ok4uw	2355	4	a	a	DT
cord-001835-0s7ok4uw	2355	5	-	-	HYPH
cord-001835-0s7ok4uw	2355	6	domain	domain	NN
cord-001835-0s7ok4uw	2355	7	rich	rich	JJ
cord-001835-0s7ok4uw	2355	8	in	in	IN
cord-001835-0s7ok4uw	2355	9	helices	helix	NNS
cord-001835-0s7ok4uw	2355	10	and	and	CC
cord-001835-0s7ok4uw	2355	11	b	b	NN
cord-001835-0s7ok4uw	2355	12	-	-	HYPH
cord-001835-0s7ok4uw	2355	13	domain	domain	NN
cord-001835-0s7ok4uw	2355	14	rich	rich	JJ
cord-001835-0s7ok4uw	2355	15	in	in	IN
cord-001835-0s7ok4uw	2355	16	sheet	sheet	NN
cord-001835-0s7ok4uw	2355	17	.	.	.
cord-001835-0s7ok4uw	2356	1	Two	two	CD
cord-001835-0s7ok4uw	2356	2	helices	helix	NNS
cord-001835-0s7ok4uw	2356	3	of	of	IN
cord-001835-0s7ok4uw	2356	4	a1	a1	NNP
cord-001835-0s7ok4uw	2356	5	and	and	CC
cord-001835-0s7ok4uw	2356	6	a2	a2	NNP
cord-001835-0s7ok4uw	2356	7	in	in	IN
cord-001835-0s7ok4uw	2356	8	the	the	DT
cord-001835-0s7ok4uw	2356	9	N	n	CD
cord-001835-0s7ok4uw	2356	10	-	-	HYPH
cord-001835-0s7ok4uw	2356	11	terminal	terminal	JJ
cord-001835-0s7ok4uw	2356	12	region	region	NN
cord-001835-0s7ok4uw	2356	13	arrange	arrange	VBP
cord-001835-0s7ok4uw	2356	14	in	in	IN
cord-001835-0s7ok4uw	2356	15	parallel	parallel	NN
cord-001835-0s7ok4uw	2356	16	and	and	CC
cord-001835-0s7ok4uw	2356	17	face	face	NN
cord-001835-0s7ok4uw	2356	18	to	to	IN
cord-001835-0s7ok4uw	2356	19	face	face	NN
cord-001835-0s7ok4uw	2357	1	where	where	WRB
cord-001835-0s7ok4uw	2357	2	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	2357	3	amino	amino	JJ
cord-001835-0s7ok4uw	2357	4	acids	acid	NNS
cord-001835-0s7ok4uw	2357	5	at	at	IN
cord-001835-0s7ok4uw	2357	6	the	the	DT
cord-001835-0s7ok4uw	2357	7	3F	3F	NNP
cord-001835-0s7ok4uw	2357	8	,	,	,
cord-001835-0s7ok4uw	2357	9	L8	L8	NNP
cord-001835-0s7ok4uw	2357	10	,	,	,
cord-001835-0s7ok4uw	2357	11	L12	L12	NNP
cord-001835-0s7ok4uw	2357	12	,	,	,
cord-001835-0s7ok4uw	2357	13	L15	L15	NNP
cord-001835-0s7ok4uw	2357	14	,	,	,
cord-001835-0s7ok4uw	2357	15	L25	L25	NNP
cord-001835-0s7ok4uw	2357	16	and	and	CC
cord-001835-0s7ok4uw	2357	17	L31	L31	NNP
cord-001835-0s7ok4uw	2357	18	allocate	allocate	VBP
cord-001835-0s7ok4uw	2357	19	with	with	IN
cord-001835-0s7ok4uw	2357	20	equal	equal	JJ
cord-001835-0s7ok4uw	2357	21	interval	interval	NN
cord-001835-0s7ok4uw	2357	22	there	there	RB
cord-001835-0s7ok4uw	2357	23	.	.	.
cord-001835-0s7ok4uw	2358	1	In	in	IN
cord-001835-0s7ok4uw	2358	2	the	the	DT
cord-001835-0s7ok4uw	2358	3	back	back	NN
cord-001835-0s7ok4uw	2358	4	of	of	IN
cord-001835-0s7ok4uw	2358	5	dock	dock	NN
cord-001835-0s7ok4uw	2358	6	,	,	,
cord-001835-0s7ok4uw	2358	7	there	there	EX
cord-001835-0s7ok4uw	2358	8	is	be	VBZ
cord-001835-0s7ok4uw	2358	9	a	a	DT
cord-001835-0s7ok4uw	2358	10	core	core	NN
cord-001835-0s7ok4uw	2358	11	region	region	NN
cord-001835-0s7ok4uw	2358	12	of	of	IN
cord-001835-0s7ok4uw	2358	13	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2358	14	fibril	fibril	NNP
cord-001835-0s7ok4uw	2358	15	formation	formation	NN
cord-001835-0s7ok4uw	2358	16	,	,	,
cord-001835-0s7ok4uw	2358	17	of	of	IN
cord-001835-0s7ok4uw	2358	18	which	which	WDT
cord-001835-0s7ok4uw	2358	19	the	the	DT
cord-001835-0s7ok4uw	2358	20	side	side	NN
cord-001835-0s7ok4uw	2358	21	chain	chain	NN
cord-001835-0s7ok4uw	2358	22	of	of	IN
cord-001835-0s7ok4uw	2358	23	I56	I56	NNP
cord-001835-0s7ok4uw	2358	24	is	be	VBZ
cord-001835-0s7ok4uw	2358	25	exposed	expose	VBN
cord-001835-0s7ok4uw	2358	26	on	on	IN
cord-001835-0s7ok4uw	2358	27	the	the	DT
cord-001835-0s7ok4uw	2358	28	protruding	protruding	NN
cord-001835-0s7ok4uw	2358	29	.	.	.
cord-001835-0s7ok4uw	2359	1	Probably	probably	RB
cord-001835-0s7ok4uw	2359	2	,	,	,
cord-001835-0s7ok4uw	2359	3	these	these	DT
cord-001835-0s7ok4uw	2359	4	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	2359	5	amino	amino	NN
cord-001835-0s7ok4uw	2359	6	acids	acid	NNS
cord-001835-0s7ok4uw	2359	7	might	may	MD
cord-001835-0s7ok4uw	2359	8	be	be	VB
cord-001835-0s7ok4uw	2359	9	crucial	crucial	JJ
cord-001835-0s7ok4uw	2359	10	for	for	IN
cord-001835-0s7ok4uw	2359	11	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	2359	12	folding	folding	NN
cord-001835-0s7ok4uw	2359	13	.	.	.
cord-001835-0s7ok4uw	2360	1	Although	although	IN
cord-001835-0s7ok4uw	2360	2	mutated	mutate	VBN
cord-001835-0s7ok4uw	2360	3	lysozymes	lysozyme	NNS
cord-001835-0s7ok4uw	2360	4	undergo	undergo	VBP
cord-001835-0s7ok4uw	2360	5	folding	folding	NN
cord-001835-0s7ok4uw	2360	6	by	by	IN
cord-001835-0s7ok4uw	2360	7	GRP78	GRP78	NNP
cord-001835-0s7ok4uw	2360	8	/	/	SYM
cord-001835-0s7ok4uw	2360	9	BiP	bip	NN
cord-001835-0s7ok4uw	2360	10	in	in	IN
cord-001835-0s7ok4uw	2360	11	such	such	JJ
cord-001835-0s7ok4uw	2360	12	environment	environment	NN
cord-001835-0s7ok4uw	2360	13	,	,	,
cord-001835-0s7ok4uw	2360	14	the	the	DT
cord-001835-0s7ok4uw	2360	15	dissociation	dissociation	NN
cord-001835-0s7ok4uw	2360	16	of	of	IN
cord-001835-0s7ok4uw	2360	17	the	the	DT
cord-001835-0s7ok4uw	2360	18	GRP	GRP	NNP
cord-001835-0s7ok4uw	2360	19	from	from	IN
cord-001835-0s7ok4uw	2360	20	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	2360	21	by	by	IN
cord-001835-0s7ok4uw	2360	22	failure	failure	NN
cord-001835-0s7ok4uw	2360	23	of	of	IN
cord-001835-0s7ok4uw	2360	24	folding	folding	NN
cord-001835-0s7ok4uw	2360	25	is	be	VBZ
cord-001835-0s7ok4uw	2360	26	likely	likely	RB
cord-001835-0s7ok4uw	2360	27	inhibited	inhibited	JJ
cord-001835-0s7ok4uw	2360	28	and	and	CC
cord-001835-0s7ok4uw	2360	29	both	both	DT
cord-001835-0s7ok4uw	2360	30	proteins	protein	NNS
cord-001835-0s7ok4uw	2360	31	remain	remain	VBP
cord-001835-0s7ok4uw	2360	32	bound	bind	VBN
cord-001835-0s7ok4uw	2360	33	to	to	IN
cord-001835-0s7ok4uw	2360	34	,	,	,
cord-001835-0s7ok4uw	2360	35	resulting	result	VBG
cord-001835-0s7ok4uw	2360	36	in	in	IN
cord-001835-0s7ok4uw	2360	37	staying	stay	VBG
cord-001835-0s7ok4uw	2360	38	to	to	IN
cord-001835-0s7ok4uw	2360	39	the	the	DT
cord-001835-0s7ok4uw	2360	40	ER	ER	NNP
cord-001835-0s7ok4uw	2360	41	.	.	.
cord-001835-0s7ok4uw	2361	1	A	a	DT
cord-001835-0s7ok4uw	2361	2	part	part	NN
cord-001835-0s7ok4uw	2361	3	of	of	IN
cord-001835-0s7ok4uw	2361	4	aberrant	aberrant	JJ
cord-001835-0s7ok4uw	2361	5	lysozymes	lysozyme	NNS
cord-001835-0s7ok4uw	2361	6	seem	seem	VBP
cord-001835-0s7ok4uw	2361	7	to	to	TO
cord-001835-0s7ok4uw	2361	8	remain	remain	VB
cord-001835-0s7ok4uw	2361	9	bound	bind	VBN
cord-001835-0s7ok4uw	2361	10	to	to	IN
cord-001835-0s7ok4uw	2361	11	GRP78	GRP78	NNP
cord-001835-0s7ok4uw	2361	12	/	/	SYM
cord-001835-0s7ok4uw	2361	13	BiP	bip	NN
cord-001835-0s7ok4uw	2361	14	during	during	IN
cord-001835-0s7ok4uw	2361	15	folding	folding	NN
cord-001835-0s7ok4uw	2361	16	and	and	CC
cord-001835-0s7ok4uw	2361	17	insolubilize	insolubilize	NN
cord-001835-0s7ok4uw	2361	18	with	with	IN
cord-001835-0s7ok4uw	2361	19	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2361	20	,	,	,
cord-001835-0s7ok4uw	2361	21	thus	thus	RB
cord-001835-0s7ok4uw	2361	22	accumulate	accumulate	VBP
cord-001835-0s7ok4uw	2361	23	in	in	IN
cord-001835-0s7ok4uw	2361	24	the	the	DT
cord-001835-0s7ok4uw	2361	25	ER	ER	NNP
cord-001835-0s7ok4uw	2361	26	accompanied	accompany	VBN
cord-001835-0s7ok4uw	2361	27	with	with	IN
cord-001835-0s7ok4uw	2361	28	ER	ER	NNP
cord-001835-0s7ok4uw	2361	29	stress	stress	NN
cord-001835-0s7ok4uw	2361	30	.	.	.
cord-001835-0s7ok4uw	2362	1	Lysozyme	Lysozyme	NNP
cord-001835-0s7ok4uw	2362	2	amyloidosis	amyloidosis	NN
cord-001835-0s7ok4uw	2362	3	might	may	MD
cord-001835-0s7ok4uw	2362	4	be	be	VB
cord-001835-0s7ok4uw	2362	5	caused	cause	VBN
cord-001835-0s7ok4uw	2362	6	by	by	IN
cord-001835-0s7ok4uw	2362	7	long	long	JJ
cord-001835-0s7ok4uw	2362	8	-	-	HYPH
cord-001835-0s7ok4uw	2362	9	term	term	NN
cord-001835-0s7ok4uw	2362	10	accumulation	accumulation	NN
cord-001835-0s7ok4uw	2362	11	in	in	IN
cord-001835-0s7ok4uw	2362	12	the	the	DT
cord-001835-0s7ok4uw	2362	13	endoplasmic	endoplasmic	NN
cord-001835-0s7ok4uw	2362	14	reticulum	reticulum	NN
cord-001835-0s7ok4uw	2362	15	of	of	IN
cord-001835-0s7ok4uw	2362	16	the	the	DT
cord-001835-0s7ok4uw	2362	17	abnormal	abnormal	JJ
cord-001835-0s7ok4uw	2362	18	protein	protein	NN
cord-001835-0s7ok4uw	2362	19	.	.	.
cord-001835-0s7ok4uw	2363	1	Structural	structural	JJ
cord-001835-0s7ok4uw	2363	2	characterization	characterization	NN
cord-001835-0s7ok4uw	2363	3	of	of	IN
cord-001835-0s7ok4uw	2363	4	toxic	toxic	JJ
cord-001835-0s7ok4uw	2363	5	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2363	6	that	that	WDT
cord-001835-0s7ok4uw	2363	7	are	be	VBP
cord-001835-0s7ok4uw	2363	8	kinetically	kinetically	RB
cord-001835-0s7ok4uw	2363	9	trapped	trap	VBN
cord-001835-0s7ok4uw	2363	10	during	during	IN
cord-001835-0s7ok4uw	2363	11	alpha	alpha	NN
cord-001835-0s7ok4uw	2363	12	-	-	HYPH
cord-001835-0s7ok4uw	2363	13	synuclein	synuclein	NNP
cord-001835-0s7ok4uw	2363	14	fibril	fibril	NNP
cord-001835-0s7ok4uw	2363	15	formation	formation	NN
cord-001835-0s7ok4uw	2364	1	The	the	DT
cord-001835-0s7ok4uw	2364	2	accumulation	accumulation	NN
cord-001835-0s7ok4uw	2364	3	of	of	IN
cord-001835-0s7ok4uw	2364	4	abnormally	abnormally	RB
cord-001835-0s7ok4uw	2364	5	aggregated	aggregate	VBN
cord-001835-0s7ok4uw	2364	6	proteins	protein	NNS
cord-001835-0s7ok4uw	2364	7	within	within	IN
cord-001835-0s7ok4uw	2364	8	the	the	DT
cord-001835-0s7ok4uw	2364	9	body	body	NN
cord-001835-0s7ok4uw	2364	10	is	be	VBZ
cord-001835-0s7ok4uw	2364	11	a	a	DT
cord-001835-0s7ok4uw	2364	12	common	common	JJ
cord-001835-0s7ok4uw	2364	13	feature	feature	NN
cord-001835-0s7ok4uw	2364	14	of	of	IN
cord-001835-0s7ok4uw	2364	15	several	several	JJ
cord-001835-0s7ok4uw	2364	16	medical	medical	JJ
cord-001835-0s7ok4uw	2364	17	disorders	disorder	NNS
cord-001835-0s7ok4uw	2364	18	,	,	,
cord-001835-0s7ok4uw	2364	19	such	such	JJ
cord-001835-0s7ok4uw	2364	20	as	as	IN
cord-001835-0s7ok4uw	2364	21	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	2364	22	's	's	POS
cord-001835-0s7ok4uw	2364	23	disease	disease	NN
cord-001835-0s7ok4uw	2364	24	,	,	,
cord-001835-0s7ok4uw	2364	25	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	2364	26	's	's	POS
cord-001835-0s7ok4uw	2364	27	disease	disease	NN
cord-001835-0s7ok4uw	2364	28	and	and	CC
cord-001835-0s7ok4uw	2364	29	diabetes	diabetes	NN
cord-001835-0s7ok4uw	2364	30	mellitus	mellitus	NN
cord-001835-0s7ok4uw	2364	31	type	type	NN
cord-001835-0s7ok4uw	2364	32	2	2	CD
cord-001835-0s7ok4uw	2364	33	.	.	.
cord-001835-0s7ok4uw	2365	1	While	while	IN
cord-001835-0s7ok4uw	2365	2	the	the	DT
cord-001835-0s7ok4uw	2365	3	specific	specific	JJ
cord-001835-0s7ok4uw	2365	4	protein	protein	NN
cord-001835-0s7ok4uw	2365	5	found	find	VBD
cord-001835-0s7ok4uw	2365	6	to	to	TO
cord-001835-0s7ok4uw	2365	7	be	be	VB
cord-001835-0s7ok4uw	2365	8	the	the	DT
cord-001835-0s7ok4uw	2365	9	major	major	JJ
cord-001835-0s7ok4uw	2365	10	component	component	NN
cord-001835-0s7ok4uw	2365	11	of	of	IN
cord-001835-0s7ok4uw	2365	12	such	such	JJ
cord-001835-0s7ok4uw	2365	13	deposits	deposit	NNS
cord-001835-0s7ok4uw	2365	14	varies	vary	VBZ
cord-001835-0s7ok4uw	2365	15	from	from	IN
cord-001835-0s7ok4uw	2365	16	one	one	CD
cord-001835-0s7ok4uw	2365	17	disease	disease	NN
cord-001835-0s7ok4uw	2365	18	to	to	IN
cord-001835-0s7ok4uw	2365	19	another	another	DT
cord-001835-0s7ok4uw	2365	20	,	,	,
cord-001835-0s7ok4uw	2365	21	the	the	DT
cord-001835-0s7ok4uw	2365	22	formation	formation	NN
cord-001835-0s7ok4uw	2365	23	of	of	IN
cord-001835-0s7ok4uw	2365	24	the	the	DT
cord-001835-0s7ok4uw	2365	25	pathological	pathological	JJ
cord-001835-0s7ok4uw	2365	26	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	2365	27	seems	seem	VBZ
cord-001835-0s7ok4uw	2365	28	to	to	TO
cord-001835-0s7ok4uw	2365	29	occur	occur	VB
cord-001835-0s7ok4uw	2365	30	via	via	IN
cord-001835-0s7ok4uw	2365	31	a	a	DT
cord-001835-0s7ok4uw	2365	32	common	common	JJ
cord-001835-0s7ok4uw	2365	33	process	process	NN
cord-001835-0s7ok4uw	2365	34	of	of	IN
cord-001835-0s7ok4uw	2365	35	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	2365	36	and	and	CC
cord-001835-0s7ok4uw	2365	37	self	self	NN
cord-001835-0s7ok4uw	2365	38	-	-	HYPH
cord-001835-0s7ok4uw	2365	39	assembly	assembly	NN
cord-001835-0s7ok4uw	2365	40	of	of	IN
cord-001835-0s7ok4uw	2365	41	a	a	DT
cord-001835-0s7ok4uw	2365	42	normally	normally	RB
cord-001835-0s7ok4uw	2365	43	soluble	soluble	JJ
cord-001835-0s7ok4uw	2365	44	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	2365	45	chain	chain	NN
cord-001835-0s7ok4uw	2365	46	into	into	IN
cord-001835-0s7ok4uw	2365	47	a	a	DT
cord-001835-0s7ok4uw	2365	48	series	series	NN
cord-001835-0s7ok4uw	2365	49	of	of	IN
cord-001835-0s7ok4uw	2365	50	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2365	51	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	2365	52	and	and	CC
cord-001835-0s7ok4uw	2365	53	,	,	,
cord-001835-0s7ok4uw	2365	54	ultimately	ultimately	RB
cord-001835-0s7ok4uw	2365	55	,	,	,
cord-001835-0s7ok4uw	2365	56	into	into	IN
cord-001835-0s7ok4uw	2365	57	insoluble	insoluble	JJ
cord-001835-0s7ok4uw	2365	58	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2365	59	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2365	60	that	that	WDT
cord-001835-0s7ok4uw	2365	61	accumulate	accumulate	VBP
cord-001835-0s7ok4uw	2365	62	within	within	IN
cord-001835-0s7ok4uw	2365	63	specific	specific	JJ
cord-001835-0s7ok4uw	2365	64	organs	organ	NNS
cord-001835-0s7ok4uw	2365	65	and	and	CC
cord-001835-0s7ok4uw	2365	66	tissues	tissue	NNS
cord-001835-0s7ok4uw	2365	67	.	.	.
cord-001835-0s7ok4uw	2366	1	Increasing	increase	VBG
cord-001835-0s7ok4uw	2366	2	evidence	evidence	NN
cord-001835-0s7ok4uw	2366	3	indicates	indicate	VBZ
cord-001835-0s7ok4uw	2366	4	that	that	IN
cord-001835-0s7ok4uw	2366	5	certain	certain	JJ
cord-001835-0s7ok4uw	2366	6	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2366	7	protein	protein	NN
cord-001835-0s7ok4uw	2366	8	species	specie	NNS
cord-001835-0s7ok4uw	2366	9	generated	generate	VBN
cord-001835-0s7ok4uw	2366	10	during	during	IN
cord-001835-0s7ok4uw	2366	11	the	the	DT
cord-001835-0s7ok4uw	2366	12	self	self	NN
cord-001835-0s7ok4uw	2366	13	-	-	HYPH
cord-001835-0s7ok4uw	2366	14	assembly	assembly	NN
cord-001835-0s7ok4uw	2366	15	of	of	IN
cord-001835-0s7ok4uw	2366	16	specific	specific	JJ
cord-001835-0s7ok4uw	2366	17	proteins	protein	NNS
cord-001835-0s7ok4uw	2366	18	into	into	IN
cord-001835-0s7ok4uw	2366	19	ordered	order	VBN
cord-001835-0s7ok4uw	2366	20	fibrillar	fibrillar	NNP
cord-001835-0s7ok4uw	2366	21	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	2366	22	can	can	MD
cord-001835-0s7ok4uw	2366	23	be	be	VB
cord-001835-0s7ok4uw	2366	24	highly	highly	RB
cord-001835-0s7ok4uw	2366	25	cytotoxic	cytotoxic	JJ
cord-001835-0s7ok4uw	2366	26	and	and	CC
cord-001835-0s7ok4uw	2366	27	are	be	VBP
cord-001835-0s7ok4uw	2366	28	likely	likely	JJ
cord-001835-0s7ok4uw	2366	29	to	to	TO
cord-001835-0s7ok4uw	2366	30	be	be	VB
cord-001835-0s7ok4uw	2366	31	key	key	JJ
cord-001835-0s7ok4uw	2366	32	players	player	NNS
cord-001835-0s7ok4uw	2366	33	in	in	IN
cord-001835-0s7ok4uw	2366	34	the	the	DT
cord-001835-0s7ok4uw	2366	35	initiation	initiation	NN
cord-001835-0s7ok4uw	2366	36	and	and	CC
cord-001835-0s7ok4uw	2366	37	spreading	spreading	NN
cord-001835-0s7ok4uw	2366	38	of	of	IN
cord-001835-0s7ok4uw	2366	39	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	2366	40	diseases	disease	NNS
cord-001835-0s7ok4uw	2366	41	.	.	.
cord-001835-0s7ok4uw	2367	1	However	however	RB
cord-001835-0s7ok4uw	2367	2	,	,	,
cord-001835-0s7ok4uw	2367	3	little	little	JJ
cord-001835-0s7ok4uw	2367	4	detailed	detailed	JJ
cord-001835-0s7ok4uw	2367	5	structural	structural	JJ
cord-001835-0s7ok4uw	2367	6	information	information	NN
cord-001835-0s7ok4uw	2367	7	is	be	VBZ
cord-001835-0s7ok4uw	2367	8	currently	currently	RB
cord-001835-0s7ok4uw	2367	9	available	available	JJ
cord-001835-0s7ok4uw	2367	10	for	for	IN
cord-001835-0s7ok4uw	2367	11	these	these	DT
cord-001835-0s7ok4uw	2367	12	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2367	13	species	specie	NNS
cord-001835-0s7ok4uw	2367	14	due	due	IN
cord-001835-0s7ok4uw	2367	15	to	to	IN
cord-001835-0s7ok4uw	2367	16	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2367	17	often	often	RB
cord-001835-0s7ok4uw	2367	18	transient	transient	JJ
cord-001835-0s7ok4uw	2367	19	nature	nature	NN
cord-001835-0s7ok4uw	2367	20	and	and	CC
cord-001835-0s7ok4uw	2367	21	,	,	,
cord-001835-0s7ok4uw	2367	22	more	more	RBR
cord-001835-0s7ok4uw	2367	23	importantly	importantly	RB
cord-001835-0s7ok4uw	2367	24	,	,	,
cord-001835-0s7ok4uw	2367	25	because	because	IN
cord-001835-0s7ok4uw	2367	26	of	of	IN
cord-001835-0s7ok4uw	2367	27	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2367	28	variability	variability	NN
cord-001835-0s7ok4uw	2367	29	in	in	IN
cord-001835-0s7ok4uw	2367	30	terms	term	NNS
cord-001835-0s7ok4uw	2367	31	of	of	IN
cord-001835-0s7ok4uw	2367	32	size	size	NN
cord-001835-0s7ok4uw	2367	33	and	and	CC
cord-001835-0s7ok4uw	2367	34	structure	structure	NN
cord-001835-0s7ok4uw	2367	35	.	.	.
cord-001835-0s7ok4uw	2368	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2368	2	report	report	VBP
cord-001835-0s7ok4uw	2368	3	here	here	RB
cord-001835-0s7ok4uw	2368	4	the	the	DT
cord-001835-0s7ok4uw	2368	5	isolation	isolation	NN
cord-001835-0s7ok4uw	2368	6	and	and	CC
cord-001835-0s7ok4uw	2368	7	detailed	detailed	JJ
cord-001835-0s7ok4uw	2368	8	characterization	characterization	NN
cord-001835-0s7ok4uw	2368	9	of	of	IN
cord-001835-0s7ok4uw	2368	10	an	an	DT
cord-001835-0s7ok4uw	2368	11	ensemble	ensemble	NN
cord-001835-0s7ok4uw	2368	12	of	of	IN
cord-001835-0s7ok4uw	2368	13	stable	stable	JJ
cord-001835-0s7ok4uw	2368	14	toxic	toxic	JJ
cord-001835-0s7ok4uw	2368	15	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2368	16	of	of	IN
cord-001835-0s7ok4uw	2368	17	alpha	alpha	NN
cord-001835-0s7ok4uw	2368	18	-	-	HYPH
cord-001835-0s7ok4uw	2368	19	synuclein	synuclein	NNP
cord-001835-0s7ok4uw	2368	20	,	,	,
cord-001835-0s7ok4uw	2368	21	the	the	DT
cord-001835-0s7ok4uw	2368	22	protein	protein	NN
cord-001835-0s7ok4uw	2368	23	whose	whose	WP$
cord-001835-0s7ok4uw	2368	24	deposition	deposition	NN
cord-001835-0s7ok4uw	2368	25	is	be	VBZ
cord-001835-0s7ok4uw	2368	26	the	the	DT
cord-001835-0s7ok4uw	2368	27	hallmark	hallmark	NN
cord-001835-0s7ok4uw	2368	28	of	of	IN
cord-001835-0s7ok4uw	2368	29	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	2368	30	's	's	POS
cord-001835-0s7ok4uw	2368	31	disease	disease	NN
cord-001835-0s7ok4uw	2368	32	.	.	.
cord-001835-0s7ok4uw	2369	1	By	by	IN
cord-001835-0s7ok4uw	2369	2	defining	define	VBG
cord-001835-0s7ok4uw	2369	3	and	and	CC
cord-001835-0s7ok4uw	2369	4	minimizing	minimize	VBG
cord-001835-0s7ok4uw	2369	5	the	the	DT
cord-001835-0s7ok4uw	2369	6	degree	degree	NN
cord-001835-0s7ok4uw	2369	7	of	of	IN
cord-001835-0s7ok4uw	2369	8	heterogeneity	heterogeneity	NN
cord-001835-0s7ok4uw	2369	9	of	of	IN
cord-001835-0s7ok4uw	2369	10	these	these	DT
cord-001835-0s7ok4uw	2369	11	isolated	isolate	VBN
cord-001835-0s7ok4uw	2369	12	alpha	alpha	NN
cord-001835-0s7ok4uw	2369	13	-	-	HYPH
cord-001835-0s7ok4uw	2369	14	synuclein	synuclein	NN
cord-001835-0s7ok4uw	2369	15	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2369	16	which	which	WDT
cord-001835-0s7ok4uw	2369	17	have	have	VBP
cord-001835-0s7ok4uw	2369	18	accumulated	accumulate	VBN
cord-001835-0s7ok4uw	2369	19	during	during	IN
cord-001835-0s7ok4uw	2369	20	the	the	DT
cord-001835-0s7ok4uw	2369	21	process	process	NN
cord-001835-0s7ok4uw	2369	22	of	of	IN
cord-001835-0s7ok4uw	2369	23	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2369	24	formation	formation	NN
cord-001835-0s7ok4uw	2369	25	,	,	,
cord-001835-0s7ok4uw	2369	26	we	-PRON-	PRP
cord-001835-0s7ok4uw	2369	27	have	have	VBP
cord-001835-0s7ok4uw	2369	28	identified	identify	VBN
cord-001835-0s7ok4uw	2369	29	distinct	distinct	JJ
cord-001835-0s7ok4uw	2369	30	subgroups	subgroup	NNS
cord-001835-0s7ok4uw	2369	31	of	of	IN
cord-001835-0s7ok4uw	2369	32	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2369	33	and	and	CC
cord-001835-0s7ok4uw	2369	34	determined	determine	VBD
cord-001835-0s7ok4uw	2369	35	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2369	36	structural	structural	JJ
cord-001835-0s7ok4uw	2369	37	properties	property	NNS
cord-001835-0s7ok4uw	2369	38	and	and	CC
cord-001835-0s7ok4uw	2369	39	three	three	CD
cord-001835-0s7ok4uw	2369	40	-	-	HYPH
cord-001835-0s7ok4uw	2369	41	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	2369	42	molecular	molecular	JJ
cord-001835-0s7ok4uw	2369	43	architectures	architecture	NNS
cord-001835-0s7ok4uw	2369	44	.	.	.
cord-001835-0s7ok4uw	2370	1	This	this	DT
cord-001835-0s7ok4uw	2370	2	characterization	characterization	NN
cord-001835-0s7ok4uw	2370	3	has	have	VBZ
cord-001835-0s7ok4uw	2370	4	been	be	VBN
cord-001835-0s7ok4uw	2370	5	achieved	achieve	VBN
cord-001835-0s7ok4uw	2370	6	by	by	IN
cord-001835-0s7ok4uw	2370	7	the	the	DT
cord-001835-0s7ok4uw	2370	8	application	application	NN
cord-001835-0s7ok4uw	2370	9	of	of	IN
cord-001835-0s7ok4uw	2370	10	a	a	DT
cord-001835-0s7ok4uw	2370	11	set	set	NN
cord-001835-0s7ok4uw	2370	12	of	of	IN
cord-001835-0s7ok4uw	2370	13	complementary	complementary	JJ
cord-001835-0s7ok4uw	2370	14	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	2370	15	techniques	technique	NNS
cord-001835-0s7ok4uw	2370	16	,	,	,
cord-001835-0s7ok4uw	2370	17	including	include	VBG
cord-001835-0s7ok4uw	2370	18	a	a	DT
cord-001835-0s7ok4uw	2370	19	variety	variety	NN
cord-001835-0s7ok4uw	2370	20	of	of	IN
cord-001835-0s7ok4uw	2370	21	spectroscopic	spectroscopic	JJ
cord-001835-0s7ok4uw	2370	22	techniques	technique	NNS
cord-001835-0s7ok4uw	2370	23	along	along	IN
cord-001835-0s7ok4uw	2370	24	with	with	IN
cord-001835-0s7ok4uw	2370	25	analytical	analytical	JJ
cord-001835-0s7ok4uw	2370	26	ultracentrifugation	ultracentrifugation	NN
cord-001835-0s7ok4uw	2370	27	,	,	,
cord-001835-0s7ok4uw	2370	28	atomic	atomic	JJ
cord-001835-0s7ok4uw	2370	29	force	force	NN
cord-001835-0s7ok4uw	2370	30	microscopy	microscopy	NNS
cord-001835-0s7ok4uw	2370	31	,	,	,
cord-001835-0s7ok4uw	2370	32	and	and	CC
cord-001835-0s7ok4uw	2370	33	electron	electron	NN
cord-001835-0s7ok4uw	2370	34	microscopy	microscopy	NN
cord-001835-0s7ok4uw	2370	35	.	.	.
cord-001835-0s7ok4uw	2371	1	Although	although	IN
cord-001835-0s7ok4uw	2371	2	these	these	DT
cord-001835-0s7ok4uw	2371	3	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2371	4	exist	exist	VBP
cord-001835-0s7ok4uw	2371	5	in	in	IN
cord-001835-0s7ok4uw	2371	6	a	a	DT
cord-001835-0s7ok4uw	2371	7	range	range	NN
cord-001835-0s7ok4uw	2371	8	of	of	IN
cord-001835-0s7ok4uw	2371	9	sizes	size	NNS
cord-001835-0s7ok4uw	2371	10	,	,	,
cord-001835-0s7ok4uw	2371	11	with	with	IN
cord-001835-0s7ok4uw	2371	12	different	different	JJ
cord-001835-0s7ok4uw	2371	13	extents	extent	NNS
cord-001835-0s7ok4uw	2371	14	and	and	CC
cord-001835-0s7ok4uw	2371	15	nature	nature	NN
cord-001835-0s7ok4uw	2371	16	of	of	IN
cord-001835-0s7ok4uw	2371	17	beta	beta	JJ
cord-001835-0s7ok4uw	2371	18	-	-	HYPH
cord-001835-0s7ok4uw	2371	19	sheet	sheet	NN
cord-001835-0s7ok4uw	2371	20	content	content	NN
cord-001835-0s7ok4uw	2371	21	and	and	CC
cord-001835-0s7ok4uw	2371	22	exposed	expose	VBN
cord-001835-0s7ok4uw	2371	23	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	2371	24	,	,	,
cord-001835-0s7ok4uw	2371	25	all	all	PDT
cord-001835-0s7ok4uw	2371	26	the	the	DT
cord-001835-0s7ok4uw	2371	27	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2371	28	subgroups	subgroup	NNS
cord-001835-0s7ok4uw	2371	29	possess	possess	VBP
cord-001835-0s7ok4uw	2371	30	hollow	hollow	JJ
cord-001835-0s7ok4uw	2371	31	cylindrical	cylindrical	JJ
cord-001835-0s7ok4uw	2371	32	architectures	architecture	NNS
cord-001835-0s7ok4uw	2371	33	with	with	IN
cord-001835-0s7ok4uw	2371	34	marked	marked	JJ
cord-001835-0s7ok4uw	2371	35	similarities	similarity	NNS
cord-001835-0s7ok4uw	2371	36	to	to	IN
cord-001835-0s7ok4uw	2371	37	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2371	38	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2371	39	.	.	.
cord-001835-0s7ok4uw	2372	1	This	this	DT
cord-001835-0s7ok4uw	2372	2	suggests	suggest	VBZ
cord-001835-0s7ok4uw	2372	3	that	that	IN
cord-001835-0s7ok4uw	2372	4	these	these	DT
cord-001835-0s7ok4uw	2372	5	types	type	NNS
cord-001835-0s7ok4uw	2372	6	of	of	IN
cord-001835-0s7ok4uw	2372	7	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2372	8	are	be	VBP
cord-001835-0s7ok4uw	2372	9	kinetically	kinetically	RB
cord-001835-0s7ok4uw	2372	10	trapped	trap	VBN
cord-001835-0s7ok4uw	2372	11	during	during	IN
cord-001835-0s7ok4uw	2372	12	protein	protein	NN
cord-001835-0s7ok4uw	2372	13	self	self	NN
cord-001835-0s7ok4uw	2372	14	-	-	HYPH
cord-001835-0s7ok4uw	2372	15	assembly	assembly	NN
cord-001835-0s7ok4uw	2372	16	and	and	CC
cord-001835-0s7ok4uw	2372	17	that	that	IN
cord-001835-0s7ok4uw	2372	18	the	the	DT
cord-001835-0s7ok4uw	2372	19	accumulation	accumulation	NN
cord-001835-0s7ok4uw	2372	20	of	of	IN
cord-001835-0s7ok4uw	2372	21	at	at	IN
cord-001835-0s7ok4uw	2372	22	least	least	JJS
cord-001835-0s7ok4uw	2372	23	some	some	DT
cord-001835-0s7ok4uw	2372	24	forms	form	NNS
cord-001835-0s7ok4uw	2372	25	of	of	IN
cord-001835-0s7ok4uw	2372	26	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2372	27	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2372	28	is	be	VBZ
cord-001835-0s7ok4uw	2372	29	likely	likely	JJ
cord-001835-0s7ok4uw	2372	30	to	to	TO
cord-001835-0s7ok4uw	2372	31	be	be	VB
cord-001835-0s7ok4uw	2372	32	a	a	DT
cord-001835-0s7ok4uw	2372	33	consequence	consequence	NN
cord-001835-0s7ok4uw	2372	34	of	of	IN
cord-001835-0s7ok4uw	2372	35	very	very	RB
cord-001835-0s7ok4uw	2372	36	slow	slow	JJ
cord-001835-0s7ok4uw	2372	37	rates	rate	NNS
cord-001835-0s7ok4uw	2372	38	of	of	IN
cord-001835-0s7ok4uw	2372	39	rearrangement	rearrangement	NN
cord-001835-0s7ok4uw	2372	40	of	of	IN
cord-001835-0s7ok4uw	2372	41	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2372	42	beta	beta	JJ
cord-001835-0s7ok4uw	2372	43	-	-	HYPH
cord-001835-0s7ok4uw	2372	44	sheet	sheet	NN
cord-001835-0s7ok4uw	2372	45	structures	structure	NNS
cord-001835-0s7ok4uw	2372	46	.	.	.
cord-001835-0s7ok4uw	2373	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2373	2	findings	finding	NNS
cord-001835-0s7ok4uw	2373	3	reveal	reveal	VBP
cord-001835-0s7ok4uw	2373	4	the	the	DT
cord-001835-0s7ok4uw	2373	5	inherent	inherent	JJ
cord-001835-0s7ok4uw	2373	6	multiplicity	multiplicity	NN
cord-001835-0s7ok4uw	2373	7	of	of	IN
cord-001835-0s7ok4uw	2373	8	pathways	pathway	NNS
cord-001835-0s7ok4uw	2373	9	of	of	IN
cord-001835-0s7ok4uw	2373	10	protein	protein	NN
cord-001835-0s7ok4uw	2373	11	misfolding	misfolding	NN
cord-001835-0s7ok4uw	2373	12	and	and	CC
cord-001835-0s7ok4uw	2373	13	the	the	DT
cord-001835-0s7ok4uw	2373	14	key	key	JJ
cord-001835-0s7ok4uw	2373	15	role	role	NN
cord-001835-0s7ok4uw	2373	16	the	the	DT
cord-001835-0s7ok4uw	2373	17	beta	beta	JJ
cord-001835-0s7ok4uw	2373	18	-	-	HYPH
cord-001835-0s7ok4uw	2373	19	sheet	sheet	NN
cord-001835-0s7ok4uw	2373	20	geometry	geometry	NN
cord-001835-0s7ok4uw	2373	21	acquired	acquire	VBN
cord-001835-0s7ok4uw	2373	22	in	in	IN
cord-001835-0s7ok4uw	2373	23	the	the	DT
cord-001835-0s7ok4uw	2373	24	early	early	JJ
cord-001835-0s7ok4uw	2373	25	stages	stage	NNS
cord-001835-0s7ok4uw	2373	26	of	of	IN
cord-001835-0s7ok4uw	2373	27	the	the	DT
cord-001835-0s7ok4uw	2373	28	self	self	NN
cord-001835-0s7ok4uw	2373	29	-	-	HYPH
cord-001835-0s7ok4uw	2373	30	assembly	assembly	NN
cord-001835-0s7ok4uw	2373	31	process	process	NN
cord-001835-0s7ok4uw	2373	32	plays	play	VBZ
cord-001835-0s7ok4uw	2373	33	in	in	IN
cord-001835-0s7ok4uw	2373	34	dictating	dictate	VBG
cord-001835-0s7ok4uw	2373	35	the	the	DT
cord-001835-0s7ok4uw	2373	36	rates	rate	NNS
cord-001835-0s7ok4uw	2373	37	of	of	IN
cord-001835-0s7ok4uw	2373	38	structural	structural	JJ
cord-001835-0s7ok4uw	2373	39	conversions	conversion	NNS
cord-001835-0s7ok4uw	2373	40	,	,	,
cord-001835-0s7ok4uw	2373	41	and	and	CC
cord-001835-0s7ok4uw	2373	42	thus	thus	RB
cord-001835-0s7ok4uw	2373	43	the	the	DT
cord-001835-0s7ok4uw	2373	44	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	2373	45	stabilities	stability	NNS
cord-001835-0s7ok4uw	2373	46	and	and	CC
cord-001835-0s7ok4uw	2373	47	pathological	pathological	JJ
cord-001835-0s7ok4uw	2373	48	nature	nature	NN
cord-001835-0s7ok4uw	2373	49	of	of	IN
cord-001835-0s7ok4uw	2373	50	different	different	JJ
cord-001835-0s7ok4uw	2373	51	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2373	52	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2373	53	.	.	.
cord-001835-0s7ok4uw	2374	1	The	the	DT
cord-001835-0s7ok4uw	2374	2	results	result	NNS
cord-001835-0s7ok4uw	2374	3	of	of	IN
cord-001835-0s7ok4uw	2374	4	this	this	DT
cord-001835-0s7ok4uw	2374	5	study	study	NN
cord-001835-0s7ok4uw	2374	6	provide	provide	VBP
cord-001835-0s7ok4uw	2374	7	the	the	DT
cord-001835-0s7ok4uw	2374	8	basis	basis	NN
cord-001835-0s7ok4uw	2374	9	for	for	IN
cord-001835-0s7ok4uw	2374	10	a	a	DT
cord-001835-0s7ok4uw	2374	11	more	more	RBR
cord-001835-0s7ok4uw	2374	12	complete	complete	JJ
cord-001835-0s7ok4uw	2374	13	understanding	understanding	NN
cord-001835-0s7ok4uw	2374	14	of	of	IN
cord-001835-0s7ok4uw	2374	15	the	the	DT
cord-001835-0s7ok4uw	2374	16	nature	nature	NN
cord-001835-0s7ok4uw	2374	17	of	of	IN
cord-001835-0s7ok4uw	2374	18	the	the	DT
cord-001835-0s7ok4uw	2374	19	self	self	NN
cord-001835-0s7ok4uw	2374	20	-	-	HYPH
cord-001835-0s7ok4uw	2374	21	assembly	assembly	NN
cord-001835-0s7ok4uw	2374	22	of	of	IN
cord-001835-0s7ok4uw	2374	23	polypeptides	polypeptide	NNS
cord-001835-0s7ok4uw	2374	24	into	into	IN
cord-001835-0s7ok4uw	2374	25	beta	beta	JJ
cord-001835-0s7ok4uw	2374	26	-	-	HYPH
cord-001835-0s7ok4uw	2374	27	sheet	sheet	NN
cord-001835-0s7ok4uw	2374	28	rich	rich	JJ
cord-001835-0s7ok4uw	2374	29	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2374	30	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	2374	31	,	,	,
cord-001835-0s7ok4uw	2374	32	and	and	CC
cord-001835-0s7ok4uw	2374	33	potentially	potentially	RB
cord-001835-0s7ok4uw	2374	34	contributes	contribute	VBZ
cord-001835-0s7ok4uw	2374	35	to	to	IN
cord-001835-0s7ok4uw	2374	36	efforts	effort	NNS
cord-001835-0s7ok4uw	2374	37	to	to	TO
cord-001835-0s7ok4uw	2374	38	identify	identify	VB
cord-001835-0s7ok4uw	2374	39	specific	specific	JJ
cord-001835-0s7ok4uw	2374	40	targets	target	NNS
cord-001835-0s7ok4uw	2374	41	for	for	IN
cord-001835-0s7ok4uw	2374	42	drug	drug	NN
cord-001835-0s7ok4uw	2374	43	discovery	discovery	NN
cord-001835-0s7ok4uw	2374	44	.	.	.
cord-001835-0s7ok4uw	2375	1	Fish	fish	NN
cord-001835-0s7ok4uw	2375	2	otoliths	otolith	NNS
cord-001835-0s7ok4uw	2375	3	and	and	CC
cord-001835-0s7ok4uw	2375	4	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	2375	5	otoconia	otoconia	NNP
cord-001835-0s7ok4uw	2375	6	,	,	,
cord-001835-0s7ok4uw	2375	7	biominerals	biominerals	NNP
cord-001835-0s7ok4uw	2375	8	composed	compose	VBN
cord-001835-0s7ok4uw	2375	9	of	of	IN
cord-001835-0s7ok4uw	2375	10	calcium	calcium	NN
cord-001835-0s7ok4uw	2375	11	carbonate	carbonate	NN
cord-001835-0s7ok4uw	2375	12	and	and	CC
cord-001835-0s7ok4uw	2375	13	organic	organic	JJ
cord-001835-0s7ok4uw	2375	14	matrix	matrix	NN
cord-001835-0s7ok4uw	2375	15	,	,	,
cord-001835-0s7ok4uw	2375	16	are	be	VBP
cord-001835-0s7ok4uw	2375	17	involved	involve	VBN
cord-001835-0s7ok4uw	2375	18	in	in	IN
cord-001835-0s7ok4uw	2375	19	the	the	DT
cord-001835-0s7ok4uw	2375	20	functioning	functioning	NN
cord-001835-0s7ok4uw	2375	21	of	of	IN
cord-001835-0s7ok4uw	2375	22	the	the	DT
cord-001835-0s7ok4uw	2375	23	inner	inner	JJ
cord-001835-0s7ok4uw	2375	24	ear	ear	NN
cord-001835-0s7ok4uw	2375	25	,	,	,
cord-001835-0s7ok4uw	2375	26	the	the	DT
cord-001835-0s7ok4uw	2375	27	sensory	sensory	JJ
cord-001835-0s7ok4uw	2375	28	organ	organ	NN
cord-001835-0s7ok4uw	2375	29	that	that	WDT
cord-001835-0s7ok4uw	2375	30	plays	play	VBZ
cord-001835-0s7ok4uw	2375	31	an	an	DT
cord-001835-0s7ok4uw	2375	32	important	important	JJ
cord-001835-0s7ok4uw	2375	33	role	role	NN
cord-001835-0s7ok4uw	2375	34	in	in	IN
cord-001835-0s7ok4uw	2375	35	hearing	hearing	NN
cord-001835-0s7ok4uw	2375	36	and	and	CC
cord-001835-0s7ok4uw	2375	37	balance	balance	NN
cord-001835-0s7ok4uw	2375	38	[	[	-LRB-
cord-001835-0s7ok4uw	2375	39	1	1	CD
cord-001835-0s7ok4uw	2375	40	]	]	-RRB-
cord-001835-0s7ok4uw	2375	41	.	.	.
cord-001835-0s7ok4uw	2376	1	However	however	RB
cord-001835-0s7ok4uw	2376	2	,	,	,
cord-001835-0s7ok4uw	2376	3	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2376	4	developmental	developmental	JJ
cord-001835-0s7ok4uw	2376	5	origins	origin	NNS
cord-001835-0s7ok4uw	2376	6	,	,	,
cord-001835-0s7ok4uw	2376	7	growth	growth	NN
cord-001835-0s7ok4uw	2376	8	,	,	,
cord-001835-0s7ok4uw	2376	9	and	and	CC
cord-001835-0s7ok4uw	2376	10	the	the	DT
cord-001835-0s7ok4uw	2376	11	role	role	NN
cord-001835-0s7ok4uw	2376	12	of	of	IN
cord-001835-0s7ok4uw	2376	13	the	the	DT
cord-001835-0s7ok4uw	2376	14	matrix	matrix	NN
cord-001835-0s7ok4uw	2376	15	,	,	,
cord-001835-0s7ok4uw	2376	16	especially	especially	RB
cord-001835-0s7ok4uw	2376	17	the	the	DT
cord-001835-0s7ok4uw	2376	18	protein	protein	NN
cord-001835-0s7ok4uw	2376	19	component	component	NN
cord-001835-0s7ok4uw	2376	20	,	,	,
cord-001835-0s7ok4uw	2376	21	are	be	VBP
cord-001835-0s7ok4uw	2376	22	still	still	RB
cord-001835-0s7ok4uw	2376	23	poorly	poorly	RB
cord-001835-0s7ok4uw	2376	24	understood	understand	VBN
cord-001835-0s7ok4uw	2376	25	.	.	.
cord-001835-0s7ok4uw	2377	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2377	2	has	have	VBZ
cord-001835-0s7ok4uw	2377	3	been	be	VBN
cord-001835-0s7ok4uw	2377	4	shown	show	VBN
cord-001835-0s7ok4uw	2377	5	that	that	IN
cord-001835-0s7ok4uw	2377	6	proteins	protein	NNS
cord-001835-0s7ok4uw	2377	7	involved	involve	VBN
cord-001835-0s7ok4uw	2377	8	in	in	IN
cord-001835-0s7ok4uw	2377	9	the	the	DT
cord-001835-0s7ok4uw	2377	10	formation	formation	NN
cord-001835-0s7ok4uw	2377	11	of	of	IN
cord-001835-0s7ok4uw	2377	12	biominerals	biomineral	NNS
cord-001835-0s7ok4uw	2377	13	are	be	VBP
cord-001835-0s7ok4uw	2377	14	usually	usually	RB
cord-001835-0s7ok4uw	2377	15	very	very	RB
cord-001835-0s7ok4uw	2377	16	acidic	acidic	JJ
cord-001835-0s7ok4uw	2377	17	.	.	.
cord-001835-0s7ok4uw	2378	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	2378	2	often	often	RB
cord-001835-0s7ok4uw	2378	3	belong	belong	VBP
cord-001835-0s7ok4uw	2378	4	to	to	IN
cord-001835-0s7ok4uw	2378	5	the	the	DT
cord-001835-0s7ok4uw	2378	6	group	group	NN
cord-001835-0s7ok4uw	2378	7	of	of	IN
cord-001835-0s7ok4uw	2378	8	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2378	9	disordered	disordered	JJ
cord-001835-0s7ok4uw	2378	10	proteins	protein	NNS
cord-001835-0s7ok4uw	2378	11	(	(	-LRB-
cord-001835-0s7ok4uw	2378	12	IDPs	IDPs	NNP
cord-001835-0s7ok4uw	2378	13	)	)	-RRB-
cord-001835-0s7ok4uw	2378	14	,	,	,
cord-001835-0s7ok4uw	2378	15	a	a	DT
cord-001835-0s7ok4uw	2378	16	class	class	NN
cord-001835-0s7ok4uw	2378	17	of	of	IN
cord-001835-0s7ok4uw	2378	18	proteins	protein	NNS
cord-001835-0s7ok4uw	2378	19	devoid	devoid	JJ
cord-001835-0s7ok4uw	2378	20	of	of	IN
cord-001835-0s7ok4uw	2378	21	a	a	DT
cord-001835-0s7ok4uw	2378	22	rigid	rigid	JJ
cord-001835-0s7ok4uw	2378	23	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	2378	24	structure	structure	NN
cord-001835-0s7ok4uw	2378	25	[	[	-LRB-
cord-001835-0s7ok4uw	2378	26	2	2	CD
cord-001835-0s7ok4uw	2378	27	,	,	,
cord-001835-0s7ok4uw	2378	28	3	3	CD
cord-001835-0s7ok4uw	2378	29	]	]	-RRB-
cord-001835-0s7ok4uw	2378	30	.	.	.
cord-001835-0s7ok4uw	2379	1	The	the	DT
cord-001835-0s7ok4uw	2379	2	shape	shape	NN
cord-001835-0s7ok4uw	2379	3	and	and	CC
cord-001835-0s7ok4uw	2379	4	polymorph	polymorph	NN
cord-001835-0s7ok4uw	2379	5	selection	selection	NN
cord-001835-0s7ok4uw	2379	6	of	of	IN
cord-001835-0s7ok4uw	2379	7	calcium	calcium	NN
cord-001835-0s7ok4uw	2379	8	carbonate	carbonate	NN
cord-001835-0s7ok4uw	2379	9	otolith	otolith	FW
cord-001835-0s7ok4uw	2379	10	in	in	IN
cord-001835-0s7ok4uw	2379	11	Danio	Danio	NNP
cord-001835-0s7ok4uw	2379	12	rerio	rerio	NNP
cord-001835-0s7ok4uw	2379	13	is	be	VBZ
cord-001835-0s7ok4uw	2379	14	controlled	control	VBN
cord-001835-0s7ok4uw	2379	15	by	by	IN
cord-001835-0s7ok4uw	2379	16	the	the	DT
cord-001835-0s7ok4uw	2379	17	Starmaker	Starmaker	NNP
cord-001835-0s7ok4uw	2379	18	(	(	-LRB-
cord-001835-0s7ok4uw	2379	19	Stm	Stm	NNP
cord-001835-0s7ok4uw	2379	20	)	)	-RRB-
cord-001835-0s7ok4uw	2379	21	protein	protein	NN
cord-001835-0s7ok4uw	2379	22	[	[	-LRB-
cord-001835-0s7ok4uw	2379	23	4	4	CD
cord-001835-0s7ok4uw	2379	24	]	]	-RRB-
cord-001835-0s7ok4uw	2379	25	.	.	.
cord-001835-0s7ok4uw	2380	1	Recently	recently	RB
cord-001835-0s7ok4uw	2380	2	,	,	,
cord-001835-0s7ok4uw	2380	3	a	a	DT
cord-001835-0s7ok4uw	2380	4	gene	gene	NN
cord-001835-0s7ok4uw	2380	5	was	be	VBD
cord-001835-0s7ok4uw	2380	6	identified	identify	VBN
cord-001835-0s7ok4uw	2380	7	encoding	encode	VBG
cord-001835-0s7ok4uw	2380	8	the	the	DT
cord-001835-0s7ok4uw	2380	9	Starmaker	Starmaker	NNP
cord-001835-0s7ok4uw	2380	10	-	-	HYPH
cord-001835-0s7ok4uw	2380	11	like	like	JJ
cord-001835-0s7ok4uw	2380	12	(	(	-LRB-
cord-001835-0s7ok4uw	2380	13	Stm	Stm	NNP
cord-001835-0s7ok4uw	2380	14	-	-	HYPH
cord-001835-0s7ok4uw	2380	15	l	l	NNP
cord-001835-0s7ok4uw	2380	16	)	)	-RRB-
cord-001835-0s7ok4uw	2380	17	protein	protein	NN
cord-001835-0s7ok4uw	2380	18	from	from	IN
cord-001835-0s7ok4uw	2380	19	Oryzias	Oryzias	NNP
cord-001835-0s7ok4uw	2380	20	latipes	latipes	NNP
cord-001835-0s7ok4uw	2380	21	,	,	,
cord-001835-0s7ok4uw	2380	22	a	a	DT
cord-001835-0s7ok4uw	2380	23	putative	putative	JJ
cord-001835-0s7ok4uw	2380	24	homologue	homologue	NN
cord-001835-0s7ok4uw	2380	25	of	of	IN
cord-001835-0s7ok4uw	2380	26	Stm	Stm	NNP
cord-001835-0s7ok4uw	2380	27	.	.	.
cord-001835-0s7ok4uw	2381	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2381	2	has	have	VBZ
cord-001835-0s7ok4uw	2381	3	been	be	VBN
cord-001835-0s7ok4uw	2381	4	suggested	suggest	VBN
cord-001835-0s7ok4uw	2381	5	that	that	IN
cord-001835-0s7ok4uw	2381	6	Stm	Stm	NNP
cord-001835-0s7ok4uw	2381	7	-	-	HYPH
cord-001835-0s7ok4uw	2381	8	l	l	NNP
cord-001835-0s7ok4uw	2381	9	has	have	VBZ
cord-001835-0s7ok4uw	2381	10	a	a	DT
cord-001835-0s7ok4uw	2381	11	similar	similar	JJ
cord-001835-0s7ok4uw	2381	12	function	function	NN
cord-001835-0s7ok4uw	2381	13	as	as	IN
cord-001835-0s7ok4uw	2381	14	Stm	Stm	NNP
cord-001835-0s7ok4uw	2381	15	,	,	,
cord-001835-0s7ok4uw	2381	16	although	although	IN
cord-001835-0s7ok4uw	2381	17	there	there	EX
cord-001835-0s7ok4uw	2381	18	is	be	VBZ
cord-001835-0s7ok4uw	2381	19	no	no	DT
cord-001835-0s7ok4uw	2381	20	sequence	sequence	NN
cord-001835-0s7ok4uw	2381	21	similarity	similarity	NN
cord-001835-0s7ok4uw	2381	22	between	between	IN
cord-001835-0s7ok4uw	2381	23	Stm	Stm	NNP
cord-001835-0s7ok4uw	2381	24	and	and	CC
cord-001835-0s7ok4uw	2381	25	Stm	Stm	NNP
cord-001835-0s7ok4uw	2381	26	-	-	HYPH
cord-001835-0s7ok4uw	2381	27	l	l	NNP
cord-001835-0s7ok4uw	2381	28	[	[	-LRB-
cord-001835-0s7ok4uw	2381	29	5	5	CD
cord-001835-0s7ok4uw	2381	30	]	]	-RRB-
cord-001835-0s7ok4uw	2381	31	.	.	.
cord-001835-0s7ok4uw	2382	1	Several	several	JJ
cord-001835-0s7ok4uw	2382	2	methods	method	NNS
cord-001835-0s7ok4uw	2382	3	,	,	,
cord-001835-0s7ok4uw	2382	4	such	such	JJ
cord-001835-0s7ok4uw	2382	5	as	as	IN
cord-001835-0s7ok4uw	2382	6	size	size	NN
cord-001835-0s7ok4uw	2382	7	exclusion	exclusion	NN
cord-001835-0s7ok4uw	2382	8	chromatography	chromatography	NN
cord-001835-0s7ok4uw	2382	9	,	,	,
cord-001835-0s7ok4uw	2382	10	CD	cd	NN
cord-001835-0s7ok4uw	2382	11	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2382	12	and	and	CC
cord-001835-0s7ok4uw	2382	13	analytical	analytical	JJ
cord-001835-0s7ok4uw	2382	14	ultracentrifugation	ultracentrifugation	NN
cord-001835-0s7ok4uw	2382	15	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	2382	16	that	that	IN
cord-001835-0s7ok4uw	2382	17	Stm	Stm	NNP
cord-001835-0s7ok4uw	2382	18	-	-	HYPH
cord-001835-0s7ok4uw	2382	19	l	l	NNP
cord-001835-0s7ok4uw	2382	20	is	be	VBZ
cord-001835-0s7ok4uw	2382	21	an	an	DT
cord-001835-0s7ok4uw	2382	22	coil	coil	NN
cord-001835-0s7ok4uw	2382	23	-	-	HYPH
cord-001835-0s7ok4uw	2382	24	like	like	JJ
cord-001835-0s7ok4uw	2382	25	IDP	IDP	NNP
cord-001835-0s7ok4uw	2382	26	,	,	,
cord-001835-0s7ok4uw	2382	27	with	with	IN
cord-001835-0s7ok4uw	2382	28	the	the	DT
cord-001835-0s7ok4uw	2382	29	tendency	tendency	NN
cord-001835-0s7ok4uw	2382	30	to	to	TO
cord-001835-0s7ok4uw	2382	31	form	form	VB
cord-001835-0s7ok4uw	2382	32	locally	locally	RB
cord-001835-0s7ok4uw	2382	33	ordered	order	VBN
cord-001835-0s7ok4uw	2382	34	structures	structure	NNS
cord-001835-0s7ok4uw	2382	35	[	[	-LRB-
cord-001835-0s7ok4uw	2382	36	6	6	CD
cord-001835-0s7ok4uw	2382	37	]	]	-RRB-
cord-001835-0s7ok4uw	2382	38	.	.	.
cord-001835-0s7ok4uw	2383	1	Because	because	IN
cord-001835-0s7ok4uw	2383	2	Stm	Stm	NNP
cord-001835-0s7ok4uw	2383	3	-	-	HYPH
cord-001835-0s7ok4uw	2383	4	l	l	NNP
cord-001835-0s7ok4uw	2383	5	was	be	VBD
cord-001835-0s7ok4uw	2383	6	suggested	suggest	VBN
cord-001835-0s7ok4uw	2383	7	to	to	TO
cord-001835-0s7ok4uw	2383	8	play	play	VB
cord-001835-0s7ok4uw	2383	9	a	a	DT
cord-001835-0s7ok4uw	2383	10	crucial	crucial	JJ
cord-001835-0s7ok4uw	2383	11	role	role	NN
cord-001835-0s7ok4uw	2383	12	in	in	IN
cord-001835-0s7ok4uw	2383	13	calcium	calcium	NN
cord-001835-0s7ok4uw	2383	14	carbonate	carbonate	NN
cord-001835-0s7ok4uw	2383	15	mineralization	mineralization	NN
cord-001835-0s7ok4uw	2383	16	,	,	,
cord-001835-0s7ok4uw	2383	17	it	-PRON-	PRP
cord-001835-0s7ok4uw	2383	18	is	be	VBZ
cord-001835-0s7ok4uw	2383	19	possible	possible	JJ
cord-001835-0s7ok4uw	2383	20	that	that	IN
cord-001835-0s7ok4uw	2383	21	calcium	calcium	NN
cord-001835-0s7ok4uw	2383	22	ions	ion	NNS
cord-001835-0s7ok4uw	2383	23	may	may	MD
cord-001835-0s7ok4uw	2383	24	influence	influence	VB
cord-001835-0s7ok4uw	2383	25	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2383	26	conformation	conformation	NN
cord-001835-0s7ok4uw	2383	27	,	,	,
cord-001835-0s7ok4uw	2383	28	as	as	IN
cord-001835-0s7ok4uw	2383	29	was	be	VBD
cord-001835-0s7ok4uw	2383	30	previously	previously	RB
cord-001835-0s7ok4uw	2383	31	shown	show	VBN
cord-001835-0s7ok4uw	2383	32	for	for	IN
cord-001835-0s7ok4uw	2383	33	Stm	Stm	NNP
cord-001835-0s7ok4uw	2383	34	[	[	-LRB-
cord-001835-0s7ok4uw	2383	35	7	7	CD
cord-001835-0s7ok4uw	2383	36	]	]	-RRB-
cord-001835-0s7ok4uw	2383	37	.	.	.
cord-001835-0s7ok4uw	2384	1	However	however	RB
cord-001835-0s7ok4uw	2384	2	,	,	,
cord-001835-0s7ok4uw	2384	3	other	other	JJ
cord-001835-0s7ok4uw	2384	4	ions	ion	NNS
cord-001835-0s7ok4uw	2384	5	may	may	MD
cord-001835-0s7ok4uw	2384	6	also	also	RB
cord-001835-0s7ok4uw	2384	7	be	be	VB
cord-001835-0s7ok4uw	2384	8	involved	involve	VBN
cord-001835-0s7ok4uw	2384	9	in	in	IN
cord-001835-0s7ok4uw	2384	10	this	this	DT
cord-001835-0s7ok4uw	2384	11	process	process	NN
cord-001835-0s7ok4uw	2384	12	.	.	.
cord-001835-0s7ok4uw	2385	1	The	the	DT
cord-001835-0s7ok4uw	2385	2	aim	aim	NN
cord-001835-0s7ok4uw	2385	3	of	of	IN
cord-001835-0s7ok4uw	2385	4	this	this	DT
cord-001835-0s7ok4uw	2385	5	study	study	NN
cord-001835-0s7ok4uw	2385	6	was	be	VBD
cord-001835-0s7ok4uw	2385	7	to	to	TO
cord-001835-0s7ok4uw	2385	8	investigate	investigate	VB
cord-001835-0s7ok4uw	2385	9	the	the	DT
cord-001835-0s7ok4uw	2385	10	effect	effect	NN
cord-001835-0s7ok4uw	2385	11	of	of	IN
cord-001835-0s7ok4uw	2385	12	mono	mono	NN
cord-001835-0s7ok4uw	2385	13	and	and	CC
cord-001835-0s7ok4uw	2385	14	divalent	divalent	JJ
cord-001835-0s7ok4uw	2385	15	metal	metal	NN
cord-001835-0s7ok4uw	2385	16	ions	ion	NNS
cord-001835-0s7ok4uw	2385	17	on	on	IN
cord-001835-0s7ok4uw	2385	18	the	the	DT
cord-001835-0s7ok4uw	2385	19	conformation	conformation	NN
cord-001835-0s7ok4uw	2385	20	of	of	IN
cord-001835-0s7ok4uw	2385	21	Stm	Stm	NNP
cord-001835-0s7ok4uw	2385	22	-	-	HYPH
cord-001835-0s7ok4uw	2385	23	l	l	NNP
cord-001835-0s7ok4uw	2385	24	.	.	.
cord-001835-0s7ok4uw	2386	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2386	2	used	use	VBD
cord-001835-0s7ok4uw	2386	3	single	single	JJ
cord-001835-0s7ok4uw	2386	4	molecule	molecule	NN
cord-001835-0s7ok4uw	2387	1	F€	F€	NNP
cord-001835-0s7ok4uw	2387	2	orster	orster	NN
cord-001835-0s7ok4uw	2387	3	resonance	resonance	NN
cord-001835-0s7ok4uw	2387	4	energy	energy	NN
cord-001835-0s7ok4uw	2387	5	transfer	transfer	NN
cord-001835-0s7ok4uw	2387	6	(	(	-LRB-
cord-001835-0s7ok4uw	2387	7	smFRET	smfret	NN
cord-001835-0s7ok4uw	2387	8	)	)	-RRB-
cord-001835-0s7ok4uw	2387	9	and	and	CC
cord-001835-0s7ok4uw	2387	10	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2387	11	correlation	correlation	NN
cord-001835-0s7ok4uw	2387	12	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2387	13	(	(	-LRB-
cord-001835-0s7ok4uw	2387	14	FCS	FCS	NNP
cord-001835-0s7ok4uw	2387	15	)	)	-RRB-
cord-001835-0s7ok4uw	2387	16	,	,	,
cord-001835-0s7ok4uw	2387	17	which	which	WDT
cord-001835-0s7ok4uw	2387	18	have	have	VBP
cord-001835-0s7ok4uw	2387	19	shown	show	VBN
cord-001835-0s7ok4uw	2387	20	that	that	IN
cord-001835-0s7ok4uw	2387	21	calcium	calcium	NN
cord-001835-0s7ok4uw	2387	22	ions	ion	NNS
cord-001835-0s7ok4uw	2387	23	compacts	compact	VBZ
cord-001835-0s7ok4uw	2387	24	the	the	DT
cord-001835-0s7ok4uw	2387	25	proteins	protein	NNS
cord-001835-0s7ok4uw	2387	26	most	most	RBS
cord-001835-0s7ok4uw	2387	27	efficiently	efficiently	RB
cord-001835-0s7ok4uw	2387	28	,	,	,
cord-001835-0s7ok4uw	2387	29	followed	follow	VBN
cord-001835-0s7ok4uw	2387	30	by	by	IN
cord-001835-0s7ok4uw	2387	31	magnesium	magnesium	NN
cord-001835-0s7ok4uw	2387	32	and	and	CC
cord-001835-0s7ok4uw	2387	33	the	the	DT
cord-001835-0s7ok4uw	2387	34	monovalent	monovalent	JJ
cord-001835-0s7ok4uw	2387	35	ions	ion	NNS
cord-001835-0s7ok4uw	2387	36	.	.	.
cord-001835-0s7ok4uw	2388	1	The	the	DT
cord-001835-0s7ok4uw	2388	2	difference	difference	NN
cord-001835-0s7ok4uw	2388	3	in	in	IN
cord-001835-0s7ok4uw	2388	4	the	the	DT
cord-001835-0s7ok4uw	2388	5	effect	effect	NN
cord-001835-0s7ok4uw	2388	6	of	of	IN
cord-001835-0s7ok4uw	2388	7	monovalent	monovalent	NN
cord-001835-0s7ok4uw	2388	8	and	and	CC
cord-001835-0s7ok4uw	2388	9	divalent	divalent	JJ
cord-001835-0s7ok4uw	2388	10	ions	ion	NNS
cord-001835-0s7ok4uw	2388	11	on	on	IN
cord-001835-0s7ok4uw	2388	12	the	the	DT
cord-001835-0s7ok4uw	2388	13	protein	protein	NN
cord-001835-0s7ok4uw	2388	14	dimensions	dimension	NNS
cord-001835-0s7ok4uw	2388	15	is	be	VBZ
cord-001835-0s7ok4uw	2388	16	likely	likely	JJ
cord-001835-0s7ok4uw	2388	17	to	to	TO
cord-001835-0s7ok4uw	2388	18	result	result	VB
cord-001835-0s7ok4uw	2388	19	from	from	IN
cord-001835-0s7ok4uw	2388	20	the	the	DT
cord-001835-0s7ok4uw	2388	21	different	different	JJ
cord-001835-0s7ok4uw	2388	22	properties	property	NNS
cord-001835-0s7ok4uw	2388	23	of	of	IN
cord-001835-0s7ok4uw	2388	24	the	the	DT
cord-001835-0s7ok4uw	2388	25	ions	ion	NNS
cord-001835-0s7ok4uw	2388	26	,	,	,
cord-001835-0s7ok4uw	2388	27	like	like	IN
cord-001835-0s7ok4uw	2388	28	charge	charge	NN
cord-001835-0s7ok4uw	2388	29	density	density	NN
cord-001835-0s7ok4uw	2388	30	and	and	CC
cord-001835-0s7ok4uw	2388	31	radius	radius	NN
cord-001835-0s7ok4uw	2388	32	.	.	.
cord-001835-0s7ok4uw	2389	1	CD	cd	NN
cord-001835-0s7ok4uw	2389	2	experiments	experiment	NNS
cord-001835-0s7ok4uw	2389	3	have	have	VBP
cord-001835-0s7ok4uw	2389	4	shown	show	VBN
cord-001835-0s7ok4uw	2389	5	that	that	IN
cord-001835-0s7ok4uw	2389	6	a	a	DT
cord-001835-0s7ok4uw	2389	7	high	high	JJ
cord-001835-0s7ok4uw	2389	8	excess	excess	NN
cord-001835-0s7ok4uw	2389	9	of	of	IN
cord-001835-0s7ok4uw	2389	10	calcium	calcium	NN
cord-001835-0s7ok4uw	2389	11	ions	ion	NNS
cord-001835-0s7ok4uw	2389	12	caused	cause	VBD
cord-001835-0s7ok4uw	2389	13	the	the	DT
cord-001835-0s7ok4uw	2389	14	formation	formation	NN
cord-001835-0s7ok4uw	2389	15	of	of	IN
cord-001835-0s7ok4uw	2389	16	ordered	order	VBN
cord-001835-0s7ok4uw	2389	17	secondary	secondary	JJ
cord-001835-0s7ok4uw	2389	18	structure	structure	NN
cord-001835-0s7ok4uw	2389	19	in	in	IN
cord-001835-0s7ok4uw	2389	20	Stm	Stm	NNP
cord-001835-0s7ok4uw	2389	21	-	-	HYPH
cord-001835-0s7ok4uw	2389	22	l	l	NNP
cord-001835-0s7ok4uw	2389	23	,	,	,
cord-001835-0s7ok4uw	2389	24	which	which	WDT
cord-001835-0s7ok4uw	2389	25	may	may	MD
cord-001835-0s7ok4uw	2389	26	be	be	VB
cord-001835-0s7ok4uw	2389	27	crucial	crucial	JJ
cord-001835-0s7ok4uw	2389	28	for	for	IN
cord-001835-0s7ok4uw	2389	29	the	the	DT
cord-001835-0s7ok4uw	2389	30	formation	formation	NN
cord-001835-0s7ok4uw	2389	31	of	of	IN
cord-001835-0s7ok4uw	2389	32	calcium	calcium	NN
cord-001835-0s7ok4uw	2389	33	carbonate	carbonate	NN
cord-001835-0s7ok4uw	2389	34	crystals	crystal	NNS
cord-001835-0s7ok4uw	2389	35	,	,	,
cord-001835-0s7ok4uw	2389	36	when	when	WRB
cord-001835-0s7ok4uw	2389	37	the	the	DT
cord-001835-0s7ok4uw	2389	38	ratio	ratio	NN
cord-001835-0s7ok4uw	2389	39	of	of	IN
cord-001835-0s7ok4uw	2389	40	building	build	VBG
cord-001835-0s7ok4uw	2389	41	ions	ion	NNS
cord-001835-0s7ok4uw	2389	42	to	to	IN
cord-001835-0s7ok4uw	2389	43	protein	protein	NN
cord-001835-0s7ok4uw	2389	44	is	be	VBZ
cord-001835-0s7ok4uw	2389	45	high	high	JJ
cord-001835-0s7ok4uw	2389	46	.	.	.
cord-001835-0s7ok4uw	2390	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2390	2	has	have	VBZ
cord-001835-0s7ok4uw	2390	3	been	be	VBN
cord-001835-0s7ok4uw	2390	4	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	2390	5	that	that	IN
cord-001835-0s7ok4uw	2390	6	DMP1	DMP1	NNP
cord-001835-0s7ok4uw	2390	7	is	be	VBZ
cord-001835-0s7ok4uw	2390	8	proteolytically	proteolytically	RB
cord-001835-0s7ok4uw	2390	9	processed	process	VBN
cord-001835-0s7ok4uw	2390	10	into	into	IN
cord-001835-0s7ok4uw	2390	11	fragments	fragment	NNS
cord-001835-0s7ok4uw	2390	12	,	,	,
cord-001835-0s7ok4uw	2390	13	including	include	VBG
cord-001835-0s7ok4uw	2390	14	37	37	CD
cord-001835-0s7ok4uw	2390	15	K	K	NNP
cord-001835-0s7ok4uw	2390	16	N	N	NNP
cord-001835-0s7ok4uw	2390	17	-	-	HYPH
cord-001835-0s7ok4uw	2390	18	terminal	terminal	NN
cord-001835-0s7ok4uw	2390	19	region	region	NN
cord-001835-0s7ok4uw	2390	20	and	and	CC
cord-001835-0s7ok4uw	2390	21	57	57	CD
cord-001835-0s7ok4uw	2390	22	K	K	NNP
cord-001835-0s7ok4uw	2390	23	C	c	NN
cord-001835-0s7ok4uw	2390	24	-	-	HYPH
cord-001835-0s7ok4uw	2390	25	terminal	terminal	NN
cord-001835-0s7ok4uw	2390	26	region	region	NN
cord-001835-0s7ok4uw	2390	27	.	.	.
cord-001835-0s7ok4uw	2391	1	As	as	IN
cord-001835-0s7ok4uw	2391	2	many	many	JJ
cord-001835-0s7ok4uw	2391	3	proteins	protein	NNS
cord-001835-0s7ok4uw	2391	4	characterized	characterize	VBN
cord-001835-0s7ok4uw	2391	5	to	to	TO
cord-001835-0s7ok4uw	2391	6	be	be	VB
cord-001835-0s7ok4uw	2391	7	engaged	engage	VBN
cord-001835-0s7ok4uw	2391	8	in	in	IN
cord-001835-0s7ok4uw	2391	9	biomineralization	biomineralization	NN
cord-001835-0s7ok4uw	2391	10	,	,	,
cord-001835-0s7ok4uw	2391	11	DMP1	DMP1	NNP
cord-001835-0s7ok4uw	2391	12	and	and	CC
cord-001835-0s7ok4uw	2391	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2391	14	fragments	fragment	NNS
cord-001835-0s7ok4uw	2391	15	belong	belong	VBP
cord-001835-0s7ok4uw	2391	16	to	to	IN
cord-001835-0s7ok4uw	2391	17	the	the	DT
cord-001835-0s7ok4uw	2391	18	group	group	NN
cord-001835-0s7ok4uw	2391	19	of	of	IN
cord-001835-0s7ok4uw	2391	20	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2391	21	disordered	disordered	JJ
cord-001835-0s7ok4uw	2391	22	proteins	protein	NNS
cord-001835-0s7ok4uw	2391	23	(	(	-LRB-
cord-001835-0s7ok4uw	2391	24	IDPs	IDPs	NNP
cord-001835-0s7ok4uw	2391	25	)	)	-RRB-
cord-001835-0s7ok4uw	2391	26	.	.	.
cord-001835-0s7ok4uw	2392	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2392	2	has	have	VBZ
cord-001835-0s7ok4uw	2392	3	been	be	VBN
cord-001835-0s7ok4uw	2392	4	suggested	suggest	VBN
cord-001835-0s7ok4uw	2392	5	that	that	IN
cord-001835-0s7ok4uw	2392	6	DMP1	DMP1	NNP
cord-001835-0s7ok4uw	2392	7	and	and	CC
cord-001835-0s7ok4uw	2392	8	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2392	9	fragments	fragment	NNS
cord-001835-0s7ok4uw	2392	10	can	can	MD
cord-001835-0s7ok4uw	2392	11	take	take	VB
cord-001835-0s7ok4uw	2392	12	a	a	DT
cord-001835-0s7ok4uw	2392	13	part	part	NN
cord-001835-0s7ok4uw	2392	14	in	in	IN
cord-001835-0s7ok4uw	2392	15	otoconia	otoconia	NNP
cord-001835-0s7ok4uw	2392	16	mineralization	mineralization	NN
cord-001835-0s7ok4uw	2392	17	,	,	,
cord-001835-0s7ok4uw	2392	18	as	as	IN
cord-001835-0s7ok4uw	2392	19	the	the	DT
cord-001835-0s7ok4uw	2392	20	protein	protein	NN
cord-001835-0s7ok4uw	2392	21	is	be	VBZ
cord-001835-0s7ok4uw	2392	22	present	present	JJ
cord-001835-0s7ok4uw	2392	23	in	in	IN
cord-001835-0s7ok4uw	2392	24	mouse	mouse	NN
cord-001835-0s7ok4uw	2392	25	otoconia	otoconia	NNP
cord-001835-0s7ok4uw	2392	26	,	,	,
cord-001835-0s7ok4uw	2392	27	but	but	CC
cord-001835-0s7ok4uw	2392	28	the	the	DT
cord-001835-0s7ok4uw	2392	29	role	role	NN
cord-001835-0s7ok4uw	2392	30	of	of	IN
cord-001835-0s7ok4uw	2392	31	DMP1	DMP1	NNP
cord-001835-0s7ok4uw	2392	32	and	and	CC
cord-001835-0s7ok4uw	2392	33	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2392	34	fragments	fragment	NNS
cord-001835-0s7ok4uw	2392	35	in	in	IN
cord-001835-0s7ok4uw	2392	36	the	the	DT
cord-001835-0s7ok4uw	2392	37	mineralization	mineralization	NN
cord-001835-0s7ok4uw	2392	38	of	of	IN
cord-001835-0s7ok4uw	2392	39	calcium	calcium	NN
cord-001835-0s7ok4uw	2392	40	carbonate	carbonate	NN
cord-001835-0s7ok4uw	2392	41	has	have	VBZ
cord-001835-0s7ok4uw	2392	42	not	not	RB
cord-001835-0s7ok4uw	2392	43	been	be	VBN
cord-001835-0s7ok4uw	2392	44	examined	examine	VBN
cord-001835-0s7ok4uw	2392	45	until	until	IN
cord-001835-0s7ok4uw	2392	46	now	now	RB
cord-001835-0s7ok4uw	2392	47	.	.	.
cord-001835-0s7ok4uw	2393	1	To	to	TO
cord-001835-0s7ok4uw	2393	2	determine	determine	VB
cord-001835-0s7ok4uw	2393	3	the	the	DT
cord-001835-0s7ok4uw	2393	4	influence	influence	NN
cord-001835-0s7ok4uw	2393	5	of	of	IN
cord-001835-0s7ok4uw	2393	6	the	the	DT
cord-001835-0s7ok4uw	2393	7	DMP1	DMP1	NNP
cord-001835-0s7ok4uw	2393	8	fragments	fragment	NNS
cord-001835-0s7ok4uw	2393	9	for	for	IN
cord-001835-0s7ok4uw	2393	10	otoconia	otoconia	NNP
cord-001835-0s7ok4uw	2393	11	development	development	NNP
cord-001835-0s7ok4uw	2393	12	,	,	,
cord-001835-0s7ok4uw	2393	13	57	57	CD
cord-001835-0s7ok4uw	2393	14	K	K	NNP
cord-001835-0s7ok4uw	2393	15	DMP1	DMP1	NNP
cord-001835-0s7ok4uw	2393	16	protein	protein	NN
cord-001835-0s7ok4uw	2393	17	was	be	VBD
cord-001835-0s7ok4uw	2393	18	expressed	express	VBN
cord-001835-0s7ok4uw	2393	19	in	in	IN
cord-001835-0s7ok4uw	2393	20	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	2393	21	expression	expression	NN
cord-001835-0s7ok4uw	2393	22	system	system	NN
cord-001835-0s7ok4uw	2393	23	,	,	,
cord-001835-0s7ok4uw	2393	24	purified	purify	VBN
cord-001835-0s7ok4uw	2393	25	and	and	CC
cord-001835-0s7ok4uw	2393	26	used	use	VBN
cord-001835-0s7ok4uw	2393	27	in	in	RP
cord-001835-0s7ok4uw	2393	28	in	in	IN
cord-001835-0s7ok4uw	2393	29	vitro	vitro	FW
cord-001835-0s7ok4uw	2393	30	biomineralization	biomineralization	NN
cord-001835-0s7ok4uw	2393	31	test	test	NN
cord-001835-0s7ok4uw	2393	32	of	of	IN
cord-001835-0s7ok4uw	2393	33	calcium	calcium	NN
cord-001835-0s7ok4uw	2393	34	carbonate	carbonate	NN
cord-001835-0s7ok4uw	2393	35	.	.	.
cord-001835-0s7ok4uw	2394	1	In	in	IN
cord-001835-0s7ok4uw	2394	2	particular	particular	JJ
cord-001835-0s7ok4uw	2394	3	,	,	,
cord-001835-0s7ok4uw	2394	4	immobilized	immobilized	JJ
cord-001835-0s7ok4uw	2394	5	metal	metal	NN
cord-001835-0s7ok4uw	2394	6	anion	anion	NN
cord-001835-0s7ok4uw	2394	7	affinity	affinity	NN
cord-001835-0s7ok4uw	2394	8	chromatography	chromatography	NN
cord-001835-0s7ok4uw	2394	9	(	(	-LRB-
cord-001835-0s7ok4uw	2394	10	IMAC	IMAC	NNP
cord-001835-0s7ok4uw	2394	11	)	)	-RRB-
cord-001835-0s7ok4uw	2394	12	was	be	VBD
cord-001835-0s7ok4uw	2394	13	applied	apply	VBN
cord-001835-0s7ok4uw	2394	14	as	as	IN
cord-001835-0s7ok4uw	2394	15	a	a	DT
cord-001835-0s7ok4uw	2394	16	first	first	JJ
cord-001835-0s7ok4uw	2394	17	step	step	NN
cord-001835-0s7ok4uw	2394	18	of	of	IN
cord-001835-0s7ok4uw	2394	19	purification	purification	NN
cord-001835-0s7ok4uw	2394	20	procedure	procedure	NN
cord-001835-0s7ok4uw	2394	21	.	.	.
cord-001835-0s7ok4uw	2395	1	Because	because	IN
cord-001835-0s7ok4uw	2395	2	of	of	IN
cord-001835-0s7ok4uw	2395	3	high	high	JJ
cord-001835-0s7ok4uw	2395	4	content	content	NN
cord-001835-0s7ok4uw	2395	5	of	of	IN
cord-001835-0s7ok4uw	2395	6	acidic	acidic	JJ
cord-001835-0s7ok4uw	2395	7	amino	amino	NN
cord-001835-0s7ok4uw	2395	8	acids	acid	NNS
cord-001835-0s7ok4uw	2395	9	,	,	,
cord-001835-0s7ok4uw	2395	10	ion	ion	NN
cord-001835-0s7ok4uw	2395	11	exchange	exchange	NN
cord-001835-0s7ok4uw	2395	12	chromatography	chromatography	NN
cord-001835-0s7ok4uw	2395	13	with	with	IN
cord-001835-0s7ok4uw	2395	14	a	a	DT
cord-001835-0s7ok4uw	2395	15	Mono	Mono	NNP
cord-001835-0s7ok4uw	2395	16	Q	Q	NNP
cord-001835-0s7ok4uw	2395	17	column	column	NN
cord-001835-0s7ok4uw	2395	18	was	be	VBD
cord-001835-0s7ok4uw	2395	19	used	use	VBN
cord-001835-0s7ok4uw	2395	20	as	as	IN
cord-001835-0s7ok4uw	2395	21	a	a	DT
cord-001835-0s7ok4uw	2395	22	next	next	JJ
cord-001835-0s7ok4uw	2395	23	step	step	NN
cord-001835-0s7ok4uw	2395	24	.	.	.
cord-001835-0s7ok4uw	2395	25	 	 	_SP
cord-001835-0s7ok4uw	2396	1	The	the	DT
cord-001835-0s7ok4uw	2396	2	development	development	NN
cord-001835-0s7ok4uw	2396	3	of	of	IN
cord-001835-0s7ok4uw	2396	4	insects	insect	NNS
cord-001835-0s7ok4uw	2396	5	is	be	VBZ
cord-001835-0s7ok4uw	2396	6	regulated	regulate	VBN
cord-001835-0s7ok4uw	2396	7	by	by	IN
cord-001835-0s7ok4uw	2396	8	the	the	DT
cord-001835-0s7ok4uw	2396	9	combined	combine	VBN
cord-001835-0s7ok4uw	2396	10	action	action	NN
cord-001835-0s7ok4uw	2396	11	of	of	IN
cord-001835-0s7ok4uw	2396	12	ecdysteroids	ecdysteroid	NNS
cord-001835-0s7ok4uw	2396	13	and	and	CC
cord-001835-0s7ok4uw	2396	14	juvenile	juvenile	JJ
cord-001835-0s7ok4uw	2396	15	hormones	hormone	NNS
cord-001835-0s7ok4uw	2396	16	(	(	-LRB-
cord-001835-0s7ok4uw	2396	17	JH	JH	NNP
cord-001835-0s7ok4uw	2396	18	)	)	-RRB-
cord-001835-0s7ok4uw	2396	19	.	.	.
cord-001835-0s7ok4uw	2397	1	Pulses	pulse	NNS
cord-001835-0s7ok4uw	2397	2	of	of	IN
cord-001835-0s7ok4uw	2397	3	20-hydroxyecdysone	20-hydroxyecdysone	CD
cord-001835-0s7ok4uw	2397	4	(	(	-LRB-
cord-001835-0s7ok4uw	2397	5	20E	20E	NNS
cord-001835-0s7ok4uw	2397	6	)	)	-RRB-
cord-001835-0s7ok4uw	2397	7	initiate	initiate	VB
cord-001835-0s7ok4uw	2397	8	each	each	DT
cord-001835-0s7ok4uw	2397	9	step	step	NN
cord-001835-0s7ok4uw	2397	10	of	of	IN
cord-001835-0s7ok4uw	2397	11	metamorphosis	metamorphosis	NN
cord-001835-0s7ok4uw	2397	12	,	,	,
cord-001835-0s7ok4uw	2397	13	while	while	IN
cord-001835-0s7ok4uw	2397	14	JH	JH	NNP
cord-001835-0s7ok4uw	2397	15	modulates	modulate	VBZ
cord-001835-0s7ok4uw	2397	16	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2397	17	action	action	NN
cord-001835-0s7ok4uw	2397	18	and	and	CC
cord-001835-0s7ok4uw	2397	19	prevents	prevent	VBZ
cord-001835-0s7ok4uw	2397	20	precocious	precocious	JJ
cord-001835-0s7ok4uw	2397	21	differentiation	differentiation	NN
cord-001835-0s7ok4uw	2397	22	.	.	.
cord-001835-0s7ok4uw	2398	1	The	the	DT
cord-001835-0s7ok4uw	2398	2	biological	biological	JJ
cord-001835-0s7ok4uw	2398	3	and	and	CC
cord-001835-0s7ok4uw	2398	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	2398	5	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2398	6	of	of	IN
cord-001835-0s7ok4uw	2398	7	20E	20E	NNP
cord-001835-0s7ok4uw	2398	8	action	action	NN
cord-001835-0s7ok4uw	2398	9	is	be	VBZ
cord-001835-0s7ok4uw	2398	10	well	well	RB
cord-001835-0s7ok4uw	2398	11	described	describe	VBN
cord-001835-0s7ok4uw	2398	12	.	.	.
cord-001835-0s7ok4uw	2399	1	In	in	IN
cord-001835-0s7ok4uw	2399	2	contrary	contrary	NN
cord-001835-0s7ok4uw	2399	3	,	,	,
cord-001835-0s7ok4uw	2399	4	the	the	DT
cord-001835-0s7ok4uw	2399	5	way	way	NN
cord-001835-0s7ok4uw	2399	6	of	of	IN
cord-001835-0s7ok4uw	2399	7	the	the	DT
cord-001835-0s7ok4uw	2399	8	JH	JH	NNP
cord-001835-0s7ok4uw	2399	9	activity	activity	NN
cord-001835-0s7ok4uw	2399	10	is	be	VBZ
cord-001835-0s7ok4uw	2399	11	still	still	RB
cord-001835-0s7ok4uw	2399	12	poorly	poorly	RB
cord-001835-0s7ok4uw	2399	13	understood	understand	VBN
cord-001835-0s7ok4uw	2399	14	.	.	.
cord-001835-0s7ok4uw	2400	1	In	in	IN
cord-001835-0s7ok4uw	2400	2	1986	1986	CD
cord-001835-0s7ok4uw	2400	3	Wilson	Wilson	NNP
cord-001835-0s7ok4uw	2400	4	and	and	CC
cord-001835-0s7ok4uw	2400	5	Fabian	Fabian	NNP
cord-001835-0s7ok4uw	2400	6	[	[	-LRB-
cord-001835-0s7ok4uw	2400	7	1	1	CD
cord-001835-0s7ok4uw	2400	8	]	]	-RRB-
cord-001835-0s7ok4uw	2400	9	reported	report	VBD
cord-001835-0s7ok4uw	2400	10	that	that	IN
cord-001835-0s7ok4uw	2400	11	Drosophila	drosophila	JJ
cord-001835-0s7ok4uw	2400	12	melanogaster	melanogaster	NN
cord-001835-0s7ok4uw	2400	13	mutants	mutant	NNS
cord-001835-0s7ok4uw	2400	14	lacking	lack	VBG
cord-001835-0s7ok4uw	2400	15	Met	Met	NNP
cord-001835-0s7ok4uw	2400	16	are	be	VBP
cord-001835-0s7ok4uw	2400	17	resistant	resistant	JJ
cord-001835-0s7ok4uw	2400	18	to	to	IN
cord-001835-0s7ok4uw	2400	19	toxic	toxic	JJ
cord-001835-0s7ok4uw	2400	20	doses	dose	NNS
cord-001835-0s7ok4uw	2400	21	of	of	IN
cord-001835-0s7ok4uw	2400	22	JH	JH	NNP
cord-001835-0s7ok4uw	2400	23	and	and	CC
cord-001835-0s7ok4uw	2400	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2400	25	analogue	analogue	NN
cord-001835-0s7ok4uw	2400	26	methoprene	methoprene	NN
cord-001835-0s7ok4uw	2400	27	.	.	.
cord-001835-0s7ok4uw	2401	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2401	2	has	have	VBZ
cord-001835-0s7ok4uw	2401	3	been	be	VBN
cord-001835-0s7ok4uw	2401	4	proved	prove	VBN
cord-001835-0s7ok4uw	2401	5	,	,	,
cord-001835-0s7ok4uw	2401	6	that	that	IN
cord-001835-0s7ok4uw	2401	7	Met	Met	NNP
cord-001835-0s7ok4uw	2401	8	binds	bind	VBZ
cord-001835-0s7ok4uw	2401	9	JH	JH	NNP
cord-001835-0s7ok4uw	2401	10	at	at	IN
cord-001835-0s7ok4uw	2401	11	physiological	physiological	JJ
cord-001835-0s7ok4uw	2401	12	conditions	condition	NNS
cord-001835-0s7ok4uw	2401	13	.	.	.
cord-001835-0s7ok4uw	2402	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	2402	2	Met	Met	NNP
cord-001835-0s7ok4uw	2402	3	is	be	VBZ
cord-001835-0s7ok4uw	2402	4	believed	believe	VBN
cord-001835-0s7ok4uw	2402	5	to	to	TO
cord-001835-0s7ok4uw	2402	6	be	be	VB
cord-001835-0s7ok4uw	2402	7	a	a	DT
cord-001835-0s7ok4uw	2402	8	putative	putative	JJ
cord-001835-0s7ok4uw	2402	9	JH	JH	NNP
cord-001835-0s7ok4uw	2402	10	receptor	receptor	NN
cord-001835-0s7ok4uw	2402	11	.	.	.
cord-001835-0s7ok4uw	2403	1	Met	Met	NNP
cord-001835-0s7ok4uw	2403	2	may	may	MD
cord-001835-0s7ok4uw	2403	3	also	also	RB
cord-001835-0s7ok4uw	2403	4	be	be	VB
cord-001835-0s7ok4uw	2403	5	involved	involve	VBN
cord-001835-0s7ok4uw	2403	6	in	in	IN
cord-001835-0s7ok4uw	2403	7	a	a	DT
cord-001835-0s7ok4uw	2403	8	cross	cross	NN
cord-001835-0s7ok4uw	2403	9	-	-	NN
cord-001835-0s7ok4uw	2403	10	talk	talk	NN
cord-001835-0s7ok4uw	2403	11	between	between	IN
cord-001835-0s7ok4uw	2403	12	two	two	CD
cord-001835-0s7ok4uw	2403	13	hormonal	hormonal	JJ
cord-001835-0s7ok4uw	2403	14	signalling	signal	VBG
cord-001835-0s7ok4uw	2403	15	pathways	pathway	NNS
cord-001835-0s7ok4uw	2403	16	,	,	,
cord-001835-0s7ok4uw	2403	17	involving	involve	VBG
cord-001835-0s7ok4uw	2403	18	20E	20E	NNP
cord-001835-0s7ok4uw	2403	19	and	and	CC
cord-001835-0s7ok4uw	2403	20	JH	JH	NNP
cord-001835-0s7ok4uw	2403	21	.	.	.
cord-001835-0s7ok4uw	2404	1	The	the	DT
cord-001835-0s7ok4uw	2404	2	detailed	detailed	JJ
cord-001835-0s7ok4uw	2404	3	structure	structure	NN
cord-001835-0s7ok4uw	2404	4	of	of	IN
cord-001835-0s7ok4uw	2404	5	Met	Met	NNP
cord-001835-0s7ok4uw	2404	6	is	be	VBZ
cord-001835-0s7ok4uw	2404	7	still	still	RB
cord-001835-0s7ok4uw	2404	8	unknown	unknown	JJ
cord-001835-0s7ok4uw	2404	9	.	.	.
cord-001835-0s7ok4uw	2405	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	2405	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2405	3	main	main	JJ
cord-001835-0s7ok4uw	2405	4	aim	aim	NN
cord-001835-0s7ok4uw	2405	5	is	be	VBZ
cord-001835-0s7ok4uw	2405	6	to	to	TO
cord-001835-0s7ok4uw	2405	7	characterize	characterize	VB
cord-001835-0s7ok4uw	2405	8	structural	structural	JJ
cord-001835-0s7ok4uw	2405	9	properties	property	NNS
cord-001835-0s7ok4uw	2405	10	of	of	IN
cord-001835-0s7ok4uw	2405	11	Met	Met	NNP
cord-001835-0s7ok4uw	2405	12	.	.	.
cord-001835-0s7ok4uw	2406	1	In	in	IN
cord-001835-0s7ok4uw	2406	2	silico	silico	NN
cord-001835-0s7ok4uw	2406	3	analysis	analysis	NN
cord-001835-0s7ok4uw	2406	4	performed	perform	VBN
cord-001835-0s7ok4uw	2406	5	on	on	IN
cord-001835-0s7ok4uw	2406	6	a	a	DT
cord-001835-0s7ok4uw	2406	7	full	full	JJ
cord-001835-0s7ok4uw	2406	8	-	-	HYPH
cord-001835-0s7ok4uw	2406	9	length	length	NN
cord-001835-0s7ok4uw	2406	10	Met	Met	NNP
cord-001835-0s7ok4uw	2406	11	suggested	suggest	VBD
cord-001835-0s7ok4uw	2406	12	,	,	,
cord-001835-0s7ok4uw	2406	13	that	that	IN
cord-001835-0s7ok4uw	2406	14	N	n	CD
cord-001835-0s7ok4uw	2406	15	-	-	HYPH
cord-001835-0s7ok4uw	2406	16	terminal	terminal	JJ
cord-001835-0s7ok4uw	2406	17	part	part	NN
cord-001835-0s7ok4uw	2406	18	of	of	IN
cord-001835-0s7ok4uw	2406	19	Met	Met	NNP
cord-001835-0s7ok4uw	2406	20	contains	contain	VBZ
cord-001835-0s7ok4uw	2406	21	three	three	CD
cord-001835-0s7ok4uw	2406	22	conserved	conserve	VBN
cord-001835-0s7ok4uw	2406	23	domains	domain	NNS
cord-001835-0s7ok4uw	2406	24	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	2406	25	for	for	IN
cord-001835-0s7ok4uw	2406	26	bHLH	bhlh	JJ
cord-001835-0s7ok4uw	2406	27	-	-	HYPH
cord-001835-0s7ok4uw	2406	28	PAS	pas	NN
cord-001835-0s7ok4uw	2406	29	transcription	transcription	NN
cord-001835-0s7ok4uw	2406	30	factors	factor	NNS
cord-001835-0s7ok4uw	2406	31	,	,	,
cord-001835-0s7ok4uw	2406	32	whereas	whereas	IN
cord-001835-0s7ok4uw	2406	33	C	c	NN
cord-001835-0s7ok4uw	2406	34	-	-	HYPH
cord-001835-0s7ok4uw	2406	35	terminal	terminal	NN
cord-001835-0s7ok4uw	2406	36	part	part	NN
cord-001835-0s7ok4uw	2406	37	is	be	VBZ
cord-001835-0s7ok4uw	2406	38	most	most	RBS
cord-001835-0s7ok4uw	2406	39	probably	probably	RB
cord-001835-0s7ok4uw	2406	40	unstructured	unstructured	JJ
cord-001835-0s7ok4uw	2406	41	.	.	.
cord-001835-0s7ok4uw	2406	42	2010	2010	CD
cord-001835-0s7ok4uw	2406	43	)	)	-RRB-
cord-001835-0s7ok4uw	2406	44	)	)	-RRB-
cord-001835-0s7ok4uw	2406	45	.	.	.
cord-001835-0s7ok4uw	2407	1	Capitalizing	capitalize	VBG
cord-001835-0s7ok4uw	2407	2	on	on	IN
cord-001835-0s7ok4uw	2407	3	self	self	NN
cord-001835-0s7ok4uw	2407	4	-	-	HYPH
cord-001835-0s7ok4uw	2407	5	and	and	CC
cord-001835-0s7ok4uw	2407	6	cross	cross	JJ
cord-001835-0s7ok4uw	2407	7	-	-	JJ
cord-001835-0s7ok4uw	2407	8	amyloid	amyloid	JJ
cord-001835-0s7ok4uw	2407	9	interactions	interaction	NNS
cord-001835-0s7ok4uw	2407	10	,	,	,
cord-001835-0s7ok4uw	2407	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	2407	12	designed	design	VBD
cord-001835-0s7ok4uw	2407	13	highly	highly	RB
cord-001835-0s7ok4uw	2407	14	effective	effective	JJ
cord-001835-0s7ok4uw	2407	15	,	,	,
cord-001835-0s7ok4uw	2407	16	peptide	peptide	NN
cord-001835-0s7ok4uw	2407	17	-	-	HYPH
cord-001835-0s7ok4uw	2407	18	based	base	VBN
cord-001835-0s7ok4uw	2407	19	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	2407	20	of	of	IN
cord-001835-0s7ok4uw	2407	21	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2407	22	self	self	NN
cord-001835-0s7ok4uw	2407	23	-	-	HYPH
cord-001835-0s7ok4uw	2407	24	assembly	assembly	NN
cord-001835-0s7ok4uw	2407	25	of	of	IN
cord-001835-0s7ok4uw	2407	26	Abeta	Abeta	NNP
cord-001835-0s7ok4uw	2407	27	and	and	CC
cord-001835-0s7ok4uw	2407	28	IAPP	IAPP	NNP
cord-001835-0s7ok4uw	2407	29	.	.	.
cord-001835-0s7ok4uw	2408	1	Due	due	IN
cord-001835-0s7ok4uw	2408	2	to	to	IN
cord-001835-0s7ok4uw	2408	3	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2408	4	favourable	favourable	JJ
cord-001835-0s7ok4uw	2408	5	properties	property	NNS
cord-001835-0s7ok4uw	2408	6	the	the	DT
cord-001835-0s7ok4uw	2408	7	designed	design	VBN
cord-001835-0s7ok4uw	2408	8	peptides	peptide	NNS
cord-001835-0s7ok4uw	2408	9	are	be	VBP
cord-001835-0s7ok4uw	2408	10	promising	promising	JJ
cord-001835-0s7ok4uw	2408	11	leads	lead	NNS
cord-001835-0s7ok4uw	2408	12	for	for	IN
cord-001835-0s7ok4uw	2408	13	targeting	target	VBG
cord-001835-0s7ok4uw	2408	14	protein	protein	NN
cord-001835-0s7ok4uw	2408	15	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2408	16	in	in	IN
cord-001835-0s7ok4uw	2408	17	AD	ad	NN
cord-001835-0s7ok4uw	2408	18	,	,	,
cord-001835-0s7ok4uw	2408	19	T2D	t2d	CD
cord-001835-0s7ok4uw	2408	20	or	or	CC
cord-001835-0s7ok4uw	2408	21	both	both	DT
cord-001835-0s7ok4uw	2408	22	diseases	disease	NNS
cord-001835-0s7ok4uw	2408	23	while	while	IN
cord-001835-0s7ok4uw	2408	24	the	the	DT
cord-001835-0s7ok4uw	2408	25	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	2408	26	design	design	NN
cord-001835-0s7ok4uw	2408	27	strategy	strategy	NN
cord-001835-0s7ok4uw	2408	28	should	should	MD
cord-001835-0s7ok4uw	2408	29	be	be	VB
cord-001835-0s7ok4uw	2408	30	applicable	applicable	JJ
cord-001835-0s7ok4uw	2408	31	to	to	IN
cord-001835-0s7ok4uw	2408	32	other	other	JJ
cord-001835-0s7ok4uw	2408	33	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	2408	34	polypeptides	polypeptide	NNS
cord-001835-0s7ok4uw	2408	35	and	and	CC
cord-001835-0s7ok4uw	2408	36	proteins	protein	NNS
cord-001835-0s7ok4uw	2408	37	as	as	RB
cord-001835-0s7ok4uw	2408	38	well	well	RB
cord-001835-0s7ok4uw	2408	39	.	.	.
cord-001835-0s7ok4uw	2408	40	 	 	_SP
cord-001835-0s7ok4uw	2409	1	Apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	2409	2	,	,	,
cord-001835-0s7ok4uw	2409	3	the	the	DT
cord-001835-0s7ok4uw	2409	4	process	process	NN
cord-001835-0s7ok4uw	2409	5	of	of	IN
cord-001835-0s7ok4uw	2409	6	programmed	program	VBN
cord-001835-0s7ok4uw	2409	7	cell	cell	NN
cord-001835-0s7ok4uw	2409	8	death	death	NN
cord-001835-0s7ok4uw	2409	9	,	,	,
cord-001835-0s7ok4uw	2409	10	must	must	MD
cord-001835-0s7ok4uw	2409	11	be	be	VB
cord-001835-0s7ok4uw	2409	12	carefully	carefully	RB
cord-001835-0s7ok4uw	2409	13	regulated	regulate	VBN
cord-001835-0s7ok4uw	2409	14	in	in	IN
cord-001835-0s7ok4uw	2409	15	multi	multi	JJ
cord-001835-0s7ok4uw	2409	16	-	-	JJ
cord-001835-0s7ok4uw	2409	17	cellular	cellular	JJ
cord-001835-0s7ok4uw	2409	18	organisms	organism	NNS
cord-001835-0s7ok4uw	2409	19	to	to	TO
cord-001835-0s7ok4uw	2409	20	ensure	ensure	VB
cord-001835-0s7ok4uw	2409	21	proper	proper	JJ
cord-001835-0s7ok4uw	2409	22	tissue	tissue	NN
cord-001835-0s7ok4uw	2409	23	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	2409	24	,	,	,
cord-001835-0s7ok4uw	2409	25	embryonic	embryonic	JJ
cord-001835-0s7ok4uw	2409	26	development	development	NN
cord-001835-0s7ok4uw	2409	27	and	and	CC
cord-001835-0s7ok4uw	2409	28	immune	immune	JJ
cord-001835-0s7ok4uw	2409	29	system	system	NN
cord-001835-0s7ok4uw	2409	30	activity	activity	NN
cord-001835-0s7ok4uw	2409	31	.	.	.
cord-001835-0s7ok4uw	2410	1	The	the	DT
cord-001835-0s7ok4uw	2410	2	Bcl-2	Bcl-2	NNP
cord-001835-0s7ok4uw	2410	3	family	family	NN
cord-001835-0s7ok4uw	2410	4	of	of	IN
cord-001835-0s7ok4uw	2410	5	proteins	protein	NNS
cord-001835-0s7ok4uw	2410	6	regulates	regulate	VBZ
cord-001835-0s7ok4uw	2410	7	the	the	DT
cord-001835-0s7ok4uw	2410	8	activation	activation	NN
cord-001835-0s7ok4uw	2410	9	of	of	IN
cord-001835-0s7ok4uw	2410	10	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	2410	11	through	through	IN
cord-001835-0s7ok4uw	2410	12	the	the	DT
cord-001835-0s7ok4uw	2410	13	mitochondria	mitochondria	NN
cord-001835-0s7ok4uw	2410	14	pathway	pathway	NN
cord-001835-0s7ok4uw	2410	15	.	.	.
cord-001835-0s7ok4uw	2411	1	Dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2411	2	interactions	interaction	NNS
cord-001835-0s7ok4uw	2411	3	between	between	IN
cord-001835-0s7ok4uw	2411	4	pro	pro	JJ
cord-001835-0s7ok4uw	2411	5	-	-	JJ
cord-001835-0s7ok4uw	2411	6	and	and	CC
cord-001835-0s7ok4uw	2411	7	anti	anti	JJ
cord-001835-0s7ok4uw	2411	8	-	-	JJ
cord-001835-0s7ok4uw	2411	9	apoptotic	apoptotic	JJ
cord-001835-0s7ok4uw	2411	10	members	member	NNS
cord-001835-0s7ok4uw	2411	11	of	of	IN
cord-001835-0s7ok4uw	2411	12	this	this	DT
cord-001835-0s7ok4uw	2411	13	family	family	NN
cord-001835-0s7ok4uw	2411	14	keep	keep	VB
cord-001835-0s7ok4uw	2411	15	each	each	DT
cord-001835-0s7ok4uw	2411	16	other	other	JJ
cord-001835-0s7ok4uw	2411	17	in	in	IN
cord-001835-0s7ok4uw	2411	18	check	check	NN
cord-001835-0s7ok4uw	2411	19	until	until	IN
cord-001835-0s7ok4uw	2411	20	the	the	DT
cord-001835-0s7ok4uw	2411	21	proper	proper	JJ
cord-001835-0s7ok4uw	2411	22	time	time	NN
cord-001835-0s7ok4uw	2411	23	to	to	TO
cord-001835-0s7ok4uw	2411	24	commit	commit	VB
cord-001835-0s7ok4uw	2411	25	to	to	IN
cord-001835-0s7ok4uw	2411	26	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	2411	27	.	.	.
cord-001835-0s7ok4uw	2412	1	The	the	DT
cord-001835-0s7ok4uw	2412	2	point	point	NN
cord-001835-0s7ok4uw	2412	3	of	of	IN
cord-001835-0s7ok4uw	2412	4	no	no	DT
cord-001835-0s7ok4uw	2412	5	return	return	NN
cord-001835-0s7ok4uw	2412	6	for	for	IN
cord-001835-0s7ok4uw	2412	7	this	this	DT
cord-001835-0s7ok4uw	2412	8	commitment	commitment	NN
cord-001835-0s7ok4uw	2412	9	is	be	VBZ
cord-001835-0s7ok4uw	2412	10	the	the	DT
cord-001835-0s7ok4uw	2412	11	permeabilization	permeabilization	NN
cord-001835-0s7ok4uw	2412	12	of	of	IN
cord-001835-0s7ok4uw	2412	13	the	the	DT
cord-001835-0s7ok4uw	2412	14	outer	outer	JJ
cord-001835-0s7ok4uw	2412	15	-	-	HYPH
cord-001835-0s7ok4uw	2412	16	mitochondrial	mitochondrial	NN
cord-001835-0s7ok4uw	2412	17	membrane	membrane	NN
cord-001835-0s7ok4uw	2412	18	(	(	-LRB-
cord-001835-0s7ok4uw	2412	19	OMM	OMM	NNP
cord-001835-0s7ok4uw	2412	20	)	)	-RRB-
cord-001835-0s7ok4uw	2412	21	.	.	.
cord-001835-0s7ok4uw	2413	1	Translocation	translocation	NN
cord-001835-0s7ok4uw	2413	2	of	of	IN
cord-001835-0s7ok4uw	2413	3	the	the	DT
cord-001835-0s7ok4uw	2413	4	pro	pro	JJ
cord-001835-0s7ok4uw	2413	5	apoptotic	apoptotic	JJ
cord-001835-0s7ok4uw	2413	6	member	member	NN
cord-001835-0s7ok4uw	2413	7	,	,	,
cord-001835-0s7ok4uw	2413	8	Bax	Bax	NNP
cord-001835-0s7ok4uw	2413	9	,	,	,
cord-001835-0s7ok4uw	2413	10	from	from	IN
cord-001835-0s7ok4uw	2413	11	the	the	DT
cord-001835-0s7ok4uw	2413	12	cytosol	cytosol	NN
cord-001835-0s7ok4uw	2413	13	to	to	IN
cord-001835-0s7ok4uw	2413	14	the	the	DT
cord-001835-0s7ok4uw	2413	15	mitochondria	mitochondria	NN
cord-001835-0s7ok4uw	2413	16	is	be	VBZ
cord-001835-0s7ok4uw	2413	17	the	the	DT
cord-001835-0s7ok4uw	2413	18	molecular	molecular	JJ
cord-001835-0s7ok4uw	2413	19	signature	signature	NN
cord-001835-0s7ok4uw	2413	20	of	of	IN
cord-001835-0s7ok4uw	2413	21	this	this	DT
cord-001835-0s7ok4uw	2413	22	event	event	NN
cord-001835-0s7ok4uw	2413	23	.	.	.
cord-001835-0s7ok4uw	2414	1	Molecular	molecular	JJ
cord-001835-0s7ok4uw	2414	2	interactions	interaction	NNS
cord-001835-0s7ok4uw	2414	3	and	and	CC
cord-001835-0s7ok4uw	2414	4	conformational	conformational	JJ
cord-001835-0s7ok4uw	2414	5	changes	change	NNS
cord-001835-0s7ok4uw	2414	6	associated	associate	VBN
cord-001835-0s7ok4uw	2414	7	with	with	IN
cord-001835-0s7ok4uw	2414	8	this	this	DT
cord-001835-0s7ok4uw	2414	9	event	event	NN
cord-001835-0s7ok4uw	2414	10	have	have	VBP
cord-001835-0s7ok4uw	2414	11	been	be	VBN
cord-001835-0s7ok4uw	2414	12	difficult	difficult	JJ
cord-001835-0s7ok4uw	2414	13	to	to	TO
cord-001835-0s7ok4uw	2414	14	obtain	obtain	VB
cord-001835-0s7ok4uw	2414	15	due	due	IN
cord-001835-0s7ok4uw	2414	16	to	to	IN
cord-001835-0s7ok4uw	2414	17	challenges	challenge	NNS
cord-001835-0s7ok4uw	2414	18	associated	associate	VBN
cord-001835-0s7ok4uw	2414	19	with	with	IN
cord-001835-0s7ok4uw	2414	20	taking	take	VBG
cord-001835-0s7ok4uw	2414	21	subtle	subtle	JJ
cord-001835-0s7ok4uw	2414	22	measurements	measurement	NNS
cord-001835-0s7ok4uw	2414	23	in	in	IN
cord-001835-0s7ok4uw	2414	24	the	the	DT
cord-001835-0s7ok4uw	2414	25	complex	complex	JJ
cord-001835-0s7ok4uw	2414	26	environment	environment	NN
cord-001835-0s7ok4uw	2414	27	of	of	IN
cord-001835-0s7ok4uw	2414	28	live	live	JJ
cord-001835-0s7ok4uw	2414	29	cells	cell	NNS
cord-001835-0s7ok4uw	2414	30	.	.	.
cord-001835-0s7ok4uw	2415	1	To	to	TO
cord-001835-0s7ok4uw	2415	2	circumvent	circumvent	VB
cord-001835-0s7ok4uw	2415	3	these	these	DT
cord-001835-0s7ok4uw	2415	4	challenges	challenge	NNS
cord-001835-0s7ok4uw	2415	5	,	,	,
cord-001835-0s7ok4uw	2415	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	2415	7	developed	develop	VBD
cord-001835-0s7ok4uw	2415	8	a	a	DT
cord-001835-0s7ok4uw	2415	9	novel	novel	JJ
cord-001835-0s7ok4uw	2415	10	method	method	NN
cord-001835-0s7ok4uw	2415	11	to	to	TO
cord-001835-0s7ok4uw	2415	12	reliably	reliably	RB
cord-001835-0s7ok4uw	2415	13	detect	detect	VB
cord-001835-0s7ok4uw	2415	14	F€	F€	NNP
cord-001835-0s7ok4uw	2415	15	orster	orster	NN
cord-001835-0s7ok4uw	2415	16	Resonance	Resonance	NNP
cord-001835-0s7ok4uw	2415	17	Energy	Energy	NNP
cord-001835-0s7ok4uw	2415	18	Transfer	Transfer	NNP
cord-001835-0s7ok4uw	2415	19	(	(	-LRB-
cord-001835-0s7ok4uw	2415	20	FRET	fret	NN
cord-001835-0s7ok4uw	2415	21	)	)	-RRB-
cord-001835-0s7ok4uw	2415	22	between	between	IN
cord-001835-0s7ok4uw	2415	23	pairs	pair	NNS
cord-001835-0s7ok4uw	2415	24	of	of	IN
cord-001835-0s7ok4uw	2415	25	fluorophores	fluorophore	NNS
cord-001835-0s7ok4uw	2415	26	to	to	TO
cord-001835-0s7ok4uw	2415	27	identify	identify	VB
cord-001835-0s7ok4uw	2415	28	intra	intra	JJ
cord-001835-0s7ok4uw	2415	29	-	-	JJ
cord-001835-0s7ok4uw	2415	30	molecular	molecular	JJ
cord-001835-0s7ok4uw	2415	31	conformational	conformational	JJ
cord-001835-0s7ok4uw	2415	32	changes	change	NNS
cord-001835-0s7ok4uw	2415	33	and	and	CC
cord-001835-0s7ok4uw	2415	34	inter	inter	JJ
cord-001835-0s7ok4uw	2415	35	-	-	JJ
cord-001835-0s7ok4uw	2415	36	molecular	molecular	JJ
cord-001835-0s7ok4uw	2415	37	contacts	contact	NNS
cord-001835-0s7ok4uw	2415	38	in	in	IN
cord-001835-0s7ok4uw	2415	39	Bax	Bax	NNP
cord-001835-0s7ok4uw	2415	40	as	as	IN
cord-001835-0s7ok4uw	2415	41	this	this	DT
cord-001835-0s7ok4uw	2415	42	translocation	translocation	NN
cord-001835-0s7ok4uw	2415	43	occurs	occur	VBZ
cord-001835-0s7ok4uw	2415	44	in	in	IN
cord-001835-0s7ok4uw	2415	45	live	live	JJ
cord-001835-0s7ok4uw	2415	46	cells	cell	NNS
cord-001835-0s7ok4uw	2415	47	.	.	.
cord-001835-0s7ok4uw	2416	1	In	in	IN
cord-001835-0s7ok4uw	2416	2	the	the	DT
cord-001835-0s7ok4uw	2416	3	cytosol	cytosol	NN
cord-001835-0s7ok4uw	2416	4	,	,	,
cord-001835-0s7ok4uw	2416	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2416	6	FRET	fret	NN
cord-001835-0s7ok4uw	2416	7	measurements	measurement	NNS
cord-001835-0s7ok4uw	2416	8	indicated	indicate	VBD
cord-001835-0s7ok4uw	2416	9	that	that	IN
cord-001835-0s7ok4uw	2416	10	the	the	DT
cord-001835-0s7ok4uw	2416	11	C	C	NNP
cord-001835-0s7ok4uw	2416	12	-	-	HYPH
cord-001835-0s7ok4uw	2416	13	terminal	terminal	NN
cord-001835-0s7ok4uw	2416	14	helix	helix	NN
cord-001835-0s7ok4uw	2416	15	is	be	VBZ
cord-001835-0s7ok4uw	2416	16	exposed	expose	VBN
cord-001835-0s7ok4uw	2416	17	instead	instead	RB
cord-001835-0s7ok4uw	2416	18	of	of	IN
cord-001835-0s7ok4uw	2416	19	tucked	tuck	VBN
cord-001835-0s7ok4uw	2416	20	away	away	RB
cord-001835-0s7ok4uw	2416	21	in	in	IN
cord-001835-0s7ok4uw	2416	22	the	the	DT
cord-001835-0s7ok4uw	2416	23	core	core	NN
cord-001835-0s7ok4uw	2416	24	of	of	IN
cord-001835-0s7ok4uw	2416	25	the	the	DT
cord-001835-0s7ok4uw	2416	26	protein	protein	NN
cord-001835-0s7ok4uw	2416	27	.	.	.
cord-001835-0s7ok4uw	2417	1	This	this	DT
cord-001835-0s7ok4uw	2417	2	coincided	coincide	VBD
cord-001835-0s7ok4uw	2417	3	with	with	IN
cord-001835-0s7ok4uw	2417	4	measurements	measurement	NNS
cord-001835-0s7ok4uw	2417	5	using	use	VBG
cord-001835-0s7ok4uw	2417	6	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2417	7	correlation	correlation	NN
cord-001835-0s7ok4uw	2417	8	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2417	9	(	(	-LRB-
cord-001835-0s7ok4uw	2417	10	FCS	FCS	NNP
cord-001835-0s7ok4uw	2417	11	)	)	-RRB-
cord-001835-0s7ok4uw	2417	12	that	that	WDT
cord-001835-0s7ok4uw	2417	13	showed	show	VBD
cord-001835-0s7ok4uw	2417	14	that	that	IN
cord-001835-0s7ok4uw	2417	15	cytosolic	cytosolic	JJ
cord-001835-0s7ok4uw	2417	16	Bax	Bax	NNP
cord-001835-0s7ok4uw	2417	17	diffuses	diffuse	VBZ
cord-001835-0s7ok4uw	2417	18	much	much	RB
cord-001835-0s7ok4uw	2417	19	slower	slow	JJR
cord-001835-0s7ok4uw	2417	20	than	than	IN
cord-001835-0s7ok4uw	2417	21	expected	expect	VBN
cord-001835-0s7ok4uw	2417	22	,	,	,
cord-001835-0s7ok4uw	2417	23	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2417	24	possible	possible	JJ
cord-001835-0s7ok4uw	2417	25	complex	complex	JJ
cord-001835-0s7ok4uw	2417	26	formation	formation	NN
cord-001835-0s7ok4uw	2417	27	or	or	CC
cord-001835-0s7ok4uw	2417	28	transient	transient	JJ
cord-001835-0s7ok4uw	2417	29	membrane	membrane	NN
cord-001835-0s7ok4uw	2417	30	interaction	interaction	NN
cord-001835-0s7ok4uw	2417	31	.	.	.
cord-001835-0s7ok4uw	2418	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2418	2	propose	propose	VBP
cord-001835-0s7ok4uw	2418	3	that	that	IN
cord-001835-0s7ok4uw	2418	4	this	this	DT
cord-001835-0s7ok4uw	2418	5	exposed	expose	VBN
cord-001835-0s7ok4uw	2418	6	helix	helix	NN
cord-001835-0s7ok4uw	2418	7	allows	allow	VBZ
cord-001835-0s7ok4uw	2418	8	for	for	IN
cord-001835-0s7ok4uw	2418	9	this	this	DT
cord-001835-0s7ok4uw	2418	10	contact	contact	NN
cord-001835-0s7ok4uw	2418	11	to	to	TO
cord-001835-0s7ok4uw	2418	12	occur	occur	VB
cord-001835-0s7ok4uw	2418	13	.	.	.
cord-001835-0s7ok4uw	2419	1	Cross	cross	NN
cord-001835-0s7ok4uw	2419	2	-	-	JJ
cord-001835-0s7ok4uw	2419	3	linking	link	VBG
cord-001835-0s7ok4uw	2419	4	the	the	DT
cord-001835-0s7ok4uw	2419	5	C	C	NNP
cord-001835-0s7ok4uw	2419	6	-	-	HYPH
cord-001835-0s7ok4uw	2419	7	terminal	terminal	NN
cord-001835-0s7ok4uw	2419	8	helix	helix	NN
cord-001835-0s7ok4uw	2419	9	(	(	-LRB-
cord-001835-0s7ok4uw	2419	10	a9	a9	NNP
cord-001835-0s7ok4uw	2419	11	)	)	-RRB-
cord-001835-0s7ok4uw	2419	12	to	to	TO
cord-001835-0s7ok4uw	2419	13	helix	helix	VB
cord-001835-0s7ok4uw	2419	14	a4	a4	NNP
cord-001835-0s7ok4uw	2419	15	reduced	reduce	VBD
cord-001835-0s7ok4uw	2419	16	the	the	DT
cord-001835-0s7ok4uw	2419	17	instances	instance	NNS
cord-001835-0s7ok4uw	2419	18	of	of	IN
cord-001835-0s7ok4uw	2419	19	these	these	DT
cord-001835-0s7ok4uw	2419	20	interactions	interaction	NNS
cord-001835-0s7ok4uw	2419	21	while	while	IN
cord-001835-0s7ok4uw	2419	22	at	at	IN
cord-001835-0s7ok4uw	2419	23	the	the	DT
cord-001835-0s7ok4uw	2419	24	same	same	JJ
cord-001835-0s7ok4uw	2419	25	time	time	NN
cord-001835-0s7ok4uw	2419	26	yielded	yield	VBD
cord-001835-0s7ok4uw	2419	27	FRET	fret	NN
cord-001835-0s7ok4uw	2419	28	measurements	measurement	NNS
cord-001835-0s7ok4uw	2419	29	that	that	WDT
cord-001835-0s7ok4uw	2419	30	are	be	VBP
cord-001835-0s7ok4uw	2419	31	consistent	consistent	JJ
cord-001835-0s7ok4uw	2419	32	with	with	IN
cord-001835-0s7ok4uw	2419	33	the	the	DT
cord-001835-0s7ok4uw	2419	34	a9	a9	NNP
cord-001835-0s7ok4uw	2419	35	helix	helix	NN
cord-001835-0s7ok4uw	2419	36	tucked	tuck	VBD
cord-001835-0s7ok4uw	2419	37	into	into	IN
cord-001835-0s7ok4uw	2419	38	the	the	DT
cord-001835-0s7ok4uw	2419	39	core	core	NN
cord-001835-0s7ok4uw	2419	40	of	of	IN
cord-001835-0s7ok4uw	2419	41	the	the	DT
cord-001835-0s7ok4uw	2419	42	protein	protein	NN
cord-001835-0s7ok4uw	2419	43	.	.	.
cord-001835-0s7ok4uw	2420	1	After	after	IN
cord-001835-0s7ok4uw	2420	2	translocation	translocation	NN
cord-001835-0s7ok4uw	2420	3	,	,	,
cord-001835-0s7ok4uw	2420	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2420	5	FRET	fret	NN
cord-001835-0s7ok4uw	2420	6	measurements	measurement	NNS
cord-001835-0s7ok4uw	2420	7	showed	show	VBD
cord-001835-0s7ok4uw	2420	8	that	that	IN
cord-001835-0s7ok4uw	2420	9	Bax	Bax	NNP
cord-001835-0s7ok4uw	2420	10	molecules	molecule	NNS
cord-001835-0s7ok4uw	2420	11	form	form	VBP
cord-001835-0s7ok4uw	2420	12	homo	homo	NN
cord-001835-0s7ok4uw	2420	13	-	-	HYPH
cord-001835-0s7ok4uw	2420	14	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2420	15	in	in	IN
cord-001835-0s7ok4uw	2420	16	the	the	DT
cord-001835-0s7ok4uw	2420	17	mitochondria	mitochondrion	NNS
cord-001835-0s7ok4uw	2420	18	through	through	IN
cord-001835-0s7ok4uw	2420	19	two	two	CD
cord-001835-0s7ok4uw	2420	20	distinct	distinct	JJ
cord-001835-0s7ok4uw	2420	21	interfaces	interface	NNS
cord-001835-0s7ok4uw	2420	22	involving	involve	VBG
cord-001835-0s7ok4uw	2420	23	the	the	DT
cord-001835-0s7ok4uw	2420	24	BH3	BH3	NNP
cord-001835-0s7ok4uw	2420	25	domain	domain	NN
cord-001835-0s7ok4uw	2420	26	(	(	-LRB-
cord-001835-0s7ok4uw	2420	27	helix	helix	NN
cord-001835-0s7ok4uw	2420	28	a2	a2	NNP
cord-001835-0s7ok4uw	2420	29	)	)	-RRB-
cord-001835-0s7ok4uw	2420	30	and	and	CC
cord-001835-0s7ok4uw	2420	31	the	the	DT
cord-001835-0s7ok4uw	2420	32	C	C	NNP
cord-001835-0s7ok4uw	2420	33	-	-	HYPH
cord-001835-0s7ok4uw	2420	34	terminal	terminal	NN
cord-001835-0s7ok4uw	2420	35	helix	helix	NN
cord-001835-0s7ok4uw	2420	36	.	.	.
cord-001835-0s7ok4uw	2421	1	These	these	DT
cord-001835-0s7ok4uw	2421	2	findings	finding	NNS
cord-001835-0s7ok4uw	2421	3	provide	provide	VBP
cord-001835-0s7ok4uw	2421	4	insight	insight	NN
cord-001835-0s7ok4uw	2421	5	into	into	IN
cord-001835-0s7ok4uw	2421	6	the	the	DT
cord-001835-0s7ok4uw	2421	7	molecular	molecular	JJ
cord-001835-0s7ok4uw	2421	8	architecture	architecture	NN
cord-001835-0s7ok4uw	2421	9	that	that	WDT
cord-001835-0s7ok4uw	2421	10	may	may	MD
cord-001835-0s7ok4uw	2421	11	involve	involve	VB
cord-001835-0s7ok4uw	2421	12	possible	possible	JJ
cord-001835-0s7ok4uw	2421	13	contacts	contact	NNS
cord-001835-0s7ok4uw	2421	14	with	with	IN
cord-001835-0s7ok4uw	2421	15	other	other	JJ
cord-001835-0s7ok4uw	2421	16	Bcl-2	Bcl-2	NNP
cord-001835-0s7ok4uw	2421	17	proteins	protein	NNS
cord-001835-0s7ok4uw	2421	18	to	to	IN
cord-001835-0s7ok4uw	2421	19	permeabilize	permeabilize	NNP
cord-001835-0s7ok4uw	2421	20	the	the	DT
cord-001835-0s7ok4uw	2421	21	OMM	OMM	NNP
cord-001835-0s7ok4uw	2421	22	,	,	,
cord-001835-0s7ok4uw	2421	23	which	which	WDT
cord-001835-0s7ok4uw	2421	24	would	would	MD
cord-001835-0s7ok4uw	2421	25	also	also	RB
cord-001835-0s7ok4uw	2421	26	be	be	VB
cord-001835-0s7ok4uw	2421	27	necessary	necessary	JJ
cord-001835-0s7ok4uw	2421	28	for	for	IN
cord-001835-0s7ok4uw	2421	29	the	the	DT
cord-001835-0s7ok4uw	2421	30	regulation	regulation	NN
cord-001835-0s7ok4uw	2421	31	of	of	IN
cord-001835-0s7ok4uw	2421	32	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	2421	33	.	.	.
cord-001835-0s7ok4uw	2422	1	ABSTRACT	abstract	JJ
cord-001835-0s7ok4uw	2422	2	spatial	spatial	JJ
cord-001835-0s7ok4uw	2422	3	resolution	resolution	NN
cord-001835-0s7ok4uw	2422	4	is	be	VBZ
cord-001835-0s7ok4uw	2422	5	especially	especially	RB
cord-001835-0s7ok4uw	2422	6	advantageous	advantageous	JJ
cord-001835-0s7ok4uw	2422	7	for	for	IN
cord-001835-0s7ok4uw	2422	8	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	2422	9	cells	cell	NNS
cord-001835-0s7ok4uw	2422	10	because	because	IN
cord-001835-0s7ok4uw	2422	11	of	of	IN
cord-001835-0s7ok4uw	2422	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2422	13	small	small	JJ
cord-001835-0s7ok4uw	2422	14	sizes	size	NNS
cord-001835-0s7ok4uw	2422	15	.	.	.
cord-001835-0s7ok4uw	2423	1	In	in	IN
cord-001835-0s7ok4uw	2423	2	the	the	DT
cord-001835-0s7ok4uw	2423	3	past	past	JJ
cord-001835-0s7ok4uw	2423	4	few	few	JJ
cord-001835-0s7ok4uw	2423	5	years	year	NNS
cord-001835-0s7ok4uw	2423	6	the	the	DT
cord-001835-0s7ok4uw	2423	7	spatial	spatial	JJ
cord-001835-0s7ok4uw	2423	8	organization	organization	NN
cord-001835-0s7ok4uw	2423	9	and	and	CC
cord-001835-0s7ok4uw	2423	10	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2423	11	of	of	IN
cord-001835-0s7ok4uw	2423	12	a	a	DT
cord-001835-0s7ok4uw	2423	13	variety	variety	NN
cord-001835-0s7ok4uw	2423	14	of	of	IN
cord-001835-0s7ok4uw	2423	15	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	2423	16	cellular	cellular	JJ
cord-001835-0s7ok4uw	2423	17	structures	structure	NNS
cord-001835-0s7ok4uw	2423	18	and	and	CC
cord-001835-0s7ok4uw	2423	19	protein	protein	NN
cord-001835-0s7ok4uw	2423	20	macromachineries	macromachinerie	NNS
cord-001835-0s7ok4uw	2423	21	have	have	VBP
cord-001835-0s7ok4uw	2423	22	been	be	VBN
cord-001835-0s7ok4uw	2423	23	revealed	reveal	VBN
cord-001835-0s7ok4uw	2423	24	with	with	IN
cord-001835-0s7ok4uw	2423	25	unprecedented	unprecedented	JJ
cord-001835-0s7ok4uw	2423	26	details	detail	NNS
cord-001835-0s7ok4uw	2423	27	.	.	.
cord-001835-0s7ok4uw	2424	1	As	as	IN
cord-001835-0s7ok4uw	2424	2	the	the	DT
cord-001835-0s7ok4uw	2424	3	field	field	NN
cord-001835-0s7ok4uw	2424	4	matures	mature	VBZ
cord-001835-0s7ok4uw	2424	5	,	,	,
cord-001835-0s7ok4uw	2424	6	it	-PRON-	PRP
cord-001835-0s7ok4uw	2424	7	is	be	VBZ
cord-001835-0s7ok4uw	2424	8	now	now	RB
cord-001835-0s7ok4uw	2424	9	time	time	NN
cord-001835-0s7ok4uw	2424	10	to	to	TO
cord-001835-0s7ok4uw	2424	11	focus	focus	VB
cord-001835-0s7ok4uw	2424	12	on	on	IN
cord-001835-0s7ok4uw	2424	13	the	the	DT
cord-001835-0s7ok4uw	2424	14	functional	functional	JJ
cord-001835-0s7ok4uw	2424	15	aspect	aspect	NN
cord-001835-0s7ok4uw	2424	16	of	of	IN
cord-001835-0s7ok4uw	2424	17	the	the	DT
cord-001835-0s7ok4uw	2424	18	observed	observed	JJ
cord-001835-0s7ok4uw	2424	19	spatial	spatial	JJ
cord-001835-0s7ok4uw	2424	20	organizations	organization	NNS
cord-001835-0s7ok4uw	2424	21	and	and	CC
cord-001835-0s7ok4uw	2424	22	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2424	23	.	.	.
cord-001835-0s7ok4uw	2425	1	Are	be	VBP
cord-001835-0s7ok4uw	2425	2	they	-PRON-	PRP
cord-001835-0s7ok4uw	2425	3	essential	essential	JJ
cord-001835-0s7ok4uw	2425	4	in	in	IN
cord-001835-0s7ok4uw	2425	5	carrying	carry	VBG
cord-001835-0s7ok4uw	2425	6	out	out	RP
cord-001835-0s7ok4uw	2425	7	a	a	DT
cord-001835-0s7ok4uw	2425	8	specific	specific	JJ
cord-001835-0s7ok4uw	2425	9	cellular	cellular	JJ
cord-001835-0s7ok4uw	2425	10	function	function	NN
cord-001835-0s7ok4uw	2425	11	?	?	.
cord-001835-0s7ok4uw	2426	1	Do	do	VBP
cord-001835-0s7ok4uw	2426	2	they	-PRON-	PRP
cord-001835-0s7ok4uw	2426	3	play	play	VB
cord-001835-0s7ok4uw	2426	4	a	a	DT
cord-001835-0s7ok4uw	2426	5	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	2426	6	role	role	NN
cord-001835-0s7ok4uw	2426	7	in	in	IN
cord-001835-0s7ok4uw	2426	8	controlling	control	VBG
cord-001835-0s7ok4uw	2426	9	the	the	DT
cord-001835-0s7ok4uw	2426	10	on	on	RB
cord-001835-0s7ok4uw	2426	11	and	and	CC
cord-001835-0s7ok4uw	2426	12	off	off	IN
cord-001835-0s7ok4uw	2426	13	of	of	IN
cord-001835-0s7ok4uw	2426	14	a	a	DT
cord-001835-0s7ok4uw	2426	15	certain	certain	JJ
cord-001835-0s7ok4uw	2426	16	cellular	cellular	JJ
cord-001835-0s7ok4uw	2426	17	process	process	NN
cord-001835-0s7ok4uw	2426	18	?	?	.
cord-001835-0s7ok4uw	2427	1	In	in	IN
cord-001835-0s7ok4uw	2427	2	this	this	DT
cord-001835-0s7ok4uw	2427	3	work	work	NN
cord-001835-0s7ok4uw	2427	4	I	-PRON-	PRP
cord-001835-0s7ok4uw	2427	5	will	will	MD
cord-001835-0s7ok4uw	2427	6	present	present	VB
cord-001835-0s7ok4uw	2427	7	a	a	DT
cord-001835-0s7ok4uw	2427	8	few	few	JJ
cord-001835-0s7ok4uw	2427	9	examples	example	NNS
cord-001835-0s7ok4uw	2427	10	from	from	IN
cord-001835-0s7ok4uw	2427	11	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2427	12	laboratory	laboratory	NN
cord-001835-0s7ok4uw	2427	13	that	that	WDT
cord-001835-0s7ok4uw	2427	14	examine	examine	VBP
cord-001835-0s7ok4uw	2427	15	the	the	DT
cord-001835-0s7ok4uw	2427	16	spatial	spatial	JJ
cord-001835-0s7ok4uw	2427	17	and	and	CC
cord-001835-0s7ok4uw	2427	18	functional	functional	JJ
cord-001835-0s7ok4uw	2427	19	organization	organization	NN
cord-001835-0s7ok4uw	2427	20	of	of	IN
cord-001835-0s7ok4uw	2427	21	macromolecules	macromolecule	NNS
cord-001835-0s7ok4uw	2427	22	involved	involve	VBN
cord-001835-0s7ok4uw	2427	23	in	in	IN
cord-001835-0s7ok4uw	2427	24	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	2427	25	cell	cell	NN
cord-001835-0s7ok4uw	2427	26	division	division	NN
cord-001835-0s7ok4uw	2427	27	.	.	.
cord-001835-0s7ok4uw	2428	1	Transcription	transcription	NN
cord-001835-0s7ok4uw	2428	2	factors	factor	NNS
cord-001835-0s7ok4uw	2428	3	(	(	-LRB-
cord-001835-0s7ok4uw	2428	4	TF	TF	NNP
cord-001835-0s7ok4uw	2428	5	)	)	-RRB-
cord-001835-0s7ok4uw	2428	6	exert	exert	VBP
cord-001835-0s7ok4uw	2428	7	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2428	8	function	function	NN
cord-001835-0s7ok4uw	2428	9	by	by	IN
cord-001835-0s7ok4uw	2428	10	interacting	interact	VBG
cord-001835-0s7ok4uw	2428	11	with	with	IN
cord-001835-0s7ok4uw	2428	12	other	other	JJ
cord-001835-0s7ok4uw	2428	13	proteins	protein	NNS
cord-001835-0s7ok4uw	2428	14	and	and	CC
cord-001835-0s7ok4uw	2428	15	binding	bind	VBG
cord-001835-0s7ok4uw	2428	16	to	to	IN
cord-001835-0s7ok4uw	2428	17	DNA	DNA	NNP
cord-001835-0s7ok4uw	2428	18	.	.	.
cord-001835-0s7ok4uw	2429	1	The	the	DT
cord-001835-0s7ok4uw	2429	2	nucleus	nucleus	NN
cord-001835-0s7ok4uw	2429	3	is	be	VBZ
cord-001835-0s7ok4uw	2429	4	a	a	DT
cord-001835-0s7ok4uw	2429	5	compartmentalized	compartmentalize	VBN
cord-001835-0s7ok4uw	2429	6	space	space	NN
cord-001835-0s7ok4uw	2429	7	,	,	,
cord-001835-0s7ok4uw	2429	8	and	and	CC
cord-001835-0s7ok4uw	2429	9	the	the	DT
cord-001835-0s7ok4uw	2429	10	spatial	spatial	JJ
cord-001835-0s7ok4uw	2429	11	organization	organization	NN
cord-001835-0s7ok4uw	2429	12	of	of	IN
cord-001835-0s7ok4uw	2429	13	TFs	TFs	NNPS
cord-001835-0s7ok4uw	2429	14	and	and	CC
cord-001835-0s7ok4uw	2429	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2429	16	partners	partner	NNS
cord-001835-0s7ok4uw	2429	17	represents	represent	VBZ
cord-001835-0s7ok4uw	2429	18	other	other	JJ
cord-001835-0s7ok4uw	2429	19	step	step	NN
cord-001835-0s7ok4uw	2429	20	of	of	IN
cord-001835-0s7ok4uw	2429	21	gene	gene	NN
cord-001835-0s7ok4uw	2429	22	expression	expression	NN
cord-001835-0s7ok4uw	2429	23	regulation	regulation	NN
cord-001835-0s7ok4uw	2429	24	.	.	.
cord-001835-0s7ok4uw	2430	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2430	2	used	use	VBD
cord-001835-0s7ok4uw	2430	3	the	the	DT
cord-001835-0s7ok4uw	2430	4	glucocorticoid	glucocorticoid	NN
cord-001835-0s7ok4uw	2430	5	receptor	receptor	NN
cord-001835-0s7ok4uw	2430	6	(	(	-LRB-
cord-001835-0s7ok4uw	2430	7	GR	GR	NNP
cord-001835-0s7ok4uw	2430	8	)	)	-RRB-
cord-001835-0s7ok4uw	2430	9	as	as	IN
cord-001835-0s7ok4uw	2430	10	a	a	DT
cord-001835-0s7ok4uw	2430	11	model	model	NN
cord-001835-0s7ok4uw	2430	12	of	of	IN
cord-001835-0s7ok4uw	2430	13	TF	TF	NNP
cord-001835-0s7ok4uw	2430	14	's	's	POS
cord-001835-0s7ok4uw	2430	15	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2430	16	of	of	IN
cord-001835-0s7ok4uw	2430	17	action	action	NN
cord-001835-0s7ok4uw	2430	18	.	.	.
cord-001835-0s7ok4uw	2431	1	GR	GR	NNP
cord-001835-0s7ok4uw	2431	2	is	be	VBZ
cord-001835-0s7ok4uw	2431	3	a	a	DT
cord-001835-0s7ok4uw	2431	4	ligand	ligand	NN
cord-001835-0s7ok4uw	2431	5	-	-	HYPH
cord-001835-0s7ok4uw	2431	6	activated	activate	VBN
cord-001835-0s7ok4uw	2431	7	TF	TF	NNP
cord-001835-0s7ok4uw	2431	8	with	with	IN
cord-001835-0s7ok4uw	2431	9	a	a	DT
cord-001835-0s7ok4uw	2431	10	relevant	relevant	JJ
cord-001835-0s7ok4uw	2431	11	role	role	NN
cord-001835-0s7ok4uw	2431	12	in	in	IN
cord-001835-0s7ok4uw	2431	13	physiology	physiology	NN
cord-001835-0s7ok4uw	2431	14	and	and	CC
cord-001835-0s7ok4uw	2431	15	a	a	DT
cord-001835-0s7ok4uw	2431	16	great	great	JJ
cord-001835-0s7ok4uw	2431	17	variety	variety	NN
cord-001835-0s7ok4uw	2431	18	of	of	IN
cord-001835-0s7ok4uw	2431	19	effects	effect	NNS
cord-001835-0s7ok4uw	2431	20	.	.	.
cord-001835-0s7ok4uw	2432	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2432	2	can	can	MD
cord-001835-0s7ok4uw	2432	3	be	be	VB
cord-001835-0s7ok4uw	2432	4	recruited	recruit	VBN
cord-001835-0s7ok4uw	2432	5	to	to	IN
cord-001835-0s7ok4uw	2432	6	specific	specific	JJ
cord-001835-0s7ok4uw	2432	7	response	response	NN
cord-001835-0s7ok4uw	2432	8	elements	element	NNS
cord-001835-0s7ok4uw	2432	9	on	on	IN
cord-001835-0s7ok4uw	2432	10	DNA	DNA	NNP
cord-001835-0s7ok4uw	2432	11	or	or	CC
cord-001835-0s7ok4uw	2432	12	interact	interact	VB
cord-001835-0s7ok4uw	2432	13	with	with	IN
cord-001835-0s7ok4uw	2432	14	other	other	JJ
cord-001835-0s7ok4uw	2432	15	TFs	tf	NNS
cord-001835-0s7ok4uw	2432	16	.	.	.
cord-001835-0s7ok4uw	2433	1	Also	also	RB
cord-001835-0s7ok4uw	2433	2	,	,	,
cord-001835-0s7ok4uw	2433	3	the	the	DT
cord-001835-0s7ok4uw	2433	4	activity	activity	NN
cord-001835-0s7ok4uw	2433	5	of	of	IN
cord-001835-0s7ok4uw	2433	6	GR	GR	NNP
cord-001835-0s7ok4uw	2433	7	is	be	VBZ
cord-001835-0s7ok4uw	2433	8	modulated	modulate	VBN
cord-001835-0s7ok4uw	2433	9	by	by	IN
cord-001835-0s7ok4uw	2433	10	different	different	JJ
cord-001835-0s7ok4uw	2433	11	co	co	NNS
cord-001835-0s7ok4uw	2433	12	-	-	NNS
cord-001835-0s7ok4uw	2433	13	regulators	regulator	NNS
cord-001835-0s7ok4uw	2433	14	,	,	,
cord-001835-0s7ok4uw	2433	15	e.g.	e.g.	RB
cord-001835-0s7ok4uw	2433	16	TIF2	TIF2	NNP
cord-001835-0s7ok4uw	2433	17	/	/	SYM
cord-001835-0s7ok4uw	2433	18	GRIP1	grip1	NN
cord-001835-0s7ok4uw	2433	19	.	.	.
cord-001835-0s7ok4uw	2434	1	GR	GR	NNP
cord-001835-0s7ok4uw	2434	2	and	and	CC
cord-001835-0s7ok4uw	2434	3	TIF2	TIF2	NNP
cord-001835-0s7ok4uw	2434	4	do	do	VBP
cord-001835-0s7ok4uw	2434	5	not	not	RB
cord-001835-0s7ok4uw	2434	6	distribute	distribute	VB
cord-001835-0s7ok4uw	2434	7	homogeneously	homogeneously	RB
cord-001835-0s7ok4uw	2434	8	within	within	IN
cord-001835-0s7ok4uw	2434	9	the	the	DT
cord-001835-0s7ok4uw	2434	10	nucleus	nucleus	NN
cord-001835-0s7ok4uw	2434	11	but	but	CC
cord-001835-0s7ok4uw	2434	12	accumulate	accumulate	VB
cord-001835-0s7ok4uw	2434	13	in	in	IN
cord-001835-0s7ok4uw	2434	14	distinctive	distinctive	JJ
cord-001835-0s7ok4uw	2434	15	clusters	cluster	NNS
cord-001835-0s7ok4uw	2434	16	.	.	.
cord-001835-0s7ok4uw	2435	1	The	the	DT
cord-001835-0s7ok4uw	2435	2	functional	functional	JJ
cord-001835-0s7ok4uw	2435	3	role	role	NN
cord-001835-0s7ok4uw	2435	4	of	of	IN
cord-001835-0s7ok4uw	2435	5	this	this	DT
cord-001835-0s7ok4uw	2435	6	particular	particular	JJ
cord-001835-0s7ok4uw	2435	7	intranuclear	intranuclear	NN
cord-001835-0s7ok4uw	2435	8	organization	organization	NN
cord-001835-0s7ok4uw	2435	9	remains	remain	VBZ
cord-001835-0s7ok4uw	2435	10	unknown	unknown	JJ
cord-001835-0s7ok4uw	2435	11	.	.	.
cord-001835-0s7ok4uw	2436	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2436	2	used	use	VBD
cord-001835-0s7ok4uw	2436	3	advanced	advanced	JJ
cord-001835-0s7ok4uw	2436	4	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2436	5	microscopy	microscopy	NN
cord-001835-0s7ok4uw	2436	6	techniques	technique	NNS
cord-001835-0s7ok4uw	2436	7	to	to	TO
cord-001835-0s7ok4uw	2436	8	study	study	VB
cord-001835-0s7ok4uw	2436	9	the	the	DT
cord-001835-0s7ok4uw	2436	10	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2436	11	of	of	IN
cord-001835-0s7ok4uw	2436	12	GR	GR	NNP
cord-001835-0s7ok4uw	2436	13	and	and	CC
cord-001835-0s7ok4uw	2436	14	TIF2	TIF2	NNP
cord-001835-0s7ok4uw	2436	15	in	in	IN
cord-001835-0s7ok4uw	2436	16	the	the	DT
cord-001835-0s7ok4uw	2436	17	nucleus	nucleus	NN
cord-001835-0s7ok4uw	2436	18	of	of	IN
cord-001835-0s7ok4uw	2436	19	living	living	NN
cord-001835-0s7ok4uw	2436	20	cells	cell	NNS
cord-001835-0s7ok4uw	2436	21	with	with	IN
cord-001835-0s7ok4uw	2436	22	high	high	JJ
cord-001835-0s7ok4uw	2436	23	spatial	spatial	JJ
cord-001835-0s7ok4uw	2436	24	and	and	CC
cord-001835-0s7ok4uw	2436	25	time	time	NN
cord-001835-0s7ok4uw	2436	26	resolution	resolution	NN
cord-001835-0s7ok4uw	2436	27	.	.	.
cord-001835-0s7ok4uw	2437	1	GR	GR	NNP
cord-001835-0s7ok4uw	2437	2	and	and	CC
cord-001835-0s7ok4uw	2437	3	TIF2	TIF2	NNP
cord-001835-0s7ok4uw	2437	4	fused	fuse	VBD
cord-001835-0s7ok4uw	2437	5	to	to	IN
cord-001835-0s7ok4uw	2437	6	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	2437	7	tags	tag	NNS
cord-001835-0s7ok4uw	2437	8	were	be	VBD
cord-001835-0s7ok4uw	2437	9	transiently	transiently	RB
cord-001835-0s7ok4uw	2437	10	expressed	express	VBN
cord-001835-0s7ok4uw	2437	11	in	in	IN
cord-001835-0s7ok4uw	2437	12	newborn	newborn	JJ
cord-001835-0s7ok4uw	2437	13	hamster	hamster	NN
cord-001835-0s7ok4uw	2437	14	kidney	kidney	NN
cord-001835-0s7ok4uw	2437	15	(	(	-LRB-
cord-001835-0s7ok4uw	2437	16	BHK	BHK	NNP
cord-001835-0s7ok4uw	2437	17	)	)	-RRB-
cord-001835-0s7ok4uw	2437	18	cells	cell	NNS
cord-001835-0s7ok4uw	2437	19	and	and	CC
cord-001835-0s7ok4uw	2437	20	visualized	visualize	VBN
cord-001835-0s7ok4uw	2437	21	by	by	IN
cord-001835-0s7ok4uw	2437	22	a	a	DT
cord-001835-0s7ok4uw	2437	23	confocal	confocal	JJ
cord-001835-0s7ok4uw	2437	24	microscope	microscope	NN
cord-001835-0s7ok4uw	2437	25	.	.	.
cord-001835-0s7ok4uw	2438	1	Fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2438	2	correlation	correlation	NN
cord-001835-0s7ok4uw	2438	3	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2438	4	(	(	-LRB-
cord-001835-0s7ok4uw	2438	5	FCS	FCS	NNP
cord-001835-0s7ok4uw	2438	6	)	)	-RRB-
cord-001835-0s7ok4uw	2438	7	experiments	experiment	NNS
cord-001835-0s7ok4uw	2438	8	were	be	VBD
cord-001835-0s7ok4uw	2438	9	carried	carry	VBN
cord-001835-0s7ok4uw	2438	10	on	on	RP
cord-001835-0s7ok4uw	2438	11	to	to	TO
cord-001835-0s7ok4uw	2438	12	measure	measure	VB
cord-001835-0s7ok4uw	2438	13	the	the	DT
cord-001835-0s7ok4uw	2438	14	intranuclear	intranuclear	NN
cord-001835-0s7ok4uw	2438	15	mobility	mobility	NN
cord-001835-0s7ok4uw	2438	16	of	of	IN
cord-001835-0s7ok4uw	2438	17	both	both	DT
cord-001835-0s7ok4uw	2438	18	proteins	protein	NNS
cord-001835-0s7ok4uw	2438	19	.	.	.
cord-001835-0s7ok4uw	2439	1	The	the	DT
cord-001835-0s7ok4uw	2439	2	method	method	NN
cord-001835-0s7ok4uw	2439	3	is	be	VBZ
cord-001835-0s7ok4uw	2439	4	based	base	VBN
cord-001835-0s7ok4uw	2439	5	on	on	IN
cord-001835-0s7ok4uw	2439	6	the	the	DT
cord-001835-0s7ok4uw	2439	7	analysis	analysis	NN
cord-001835-0s7ok4uw	2439	8	of	of	IN
cord-001835-0s7ok4uw	2439	9	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2439	10	intensity	intensity	NN
cord-001835-0s7ok4uw	2439	11	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	2439	12	due	due	IN
cord-001835-0s7ok4uw	2439	13	to	to	IN
cord-001835-0s7ok4uw	2439	14	the	the	DT
cord-001835-0s7ok4uw	2439	15	movement	movement	NN
cord-001835-0s7ok4uw	2439	16	of	of	IN
cord-001835-0s7ok4uw	2439	17	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	2439	18	molecules	molecule	NNS
cord-001835-0s7ok4uw	2439	19	in	in	IN
cord-001835-0s7ok4uw	2439	20	and	and	CC
cord-001835-0s7ok4uw	2439	21	out	out	IN
cord-001835-0s7ok4uw	2439	22	the	the	DT
cord-001835-0s7ok4uw	2439	23	confocal	confocal	JJ
cord-001835-0s7ok4uw	2439	24	volume	volume	NN
cord-001835-0s7ok4uw	2439	25	.	.	.
cord-001835-0s7ok4uw	2440	1	The	the	DT
cord-001835-0s7ok4uw	2440	2	data	datum	NNS
cord-001835-0s7ok4uw	2440	3	could	could	MD
cord-001835-0s7ok4uw	2440	4	be	be	VB
cord-001835-0s7ok4uw	2440	5	fitted	fit	VBN
cord-001835-0s7ok4uw	2440	6	with	with	IN
cord-001835-0s7ok4uw	2440	7	a	a	DT
cord-001835-0s7ok4uw	2440	8	model	model	NN
cord-001835-0s7ok4uw	2440	9	that	that	WDT
cord-001835-0s7ok4uw	2440	10	considers	consider	VBZ
cord-001835-0s7ok4uw	2440	11	a	a	DT
cord-001835-0s7ok4uw	2440	12	free	free	JJ
cord-001835-0s7ok4uw	2440	13	diffusion	diffusion	NN
cord-001835-0s7ok4uw	2440	14	of	of	IN
cord-001835-0s7ok4uw	2440	15	TIF2	TIF2	NNP
cord-001835-0s7ok4uw	2440	16	and	and	CC
cord-001835-0s7ok4uw	2440	17	GR	GR	NNP
cord-001835-0s7ok4uw	2440	18	in	in	IN
cord-001835-0s7ok4uw	2440	19	the	the	DT
cord-001835-0s7ok4uw	2440	20	nucleus	nucleus	NN
cord-001835-0s7ok4uw	2440	21	and	and	CC
cord-001835-0s7ok4uw	2440	22	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2440	23	binding	binding	NN
cord-001835-0s7ok4uw	2440	24	to	to	IN
cord-001835-0s7ok4uw	2440	25	fixed	fix	VBN
cord-001835-0s7ok4uw	2440	26	targets	target	NNS
cord-001835-0s7ok4uw	2440	27	.	.	.
cord-001835-0s7ok4uw	2441	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2441	2	also	also	RB
cord-001835-0s7ok4uw	2441	3	studied	study	VBD
cord-001835-0s7ok4uw	2441	4	the	the	DT
cord-001835-0s7ok4uw	2441	5	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2441	6	of	of	IN
cord-001835-0s7ok4uw	2441	7	different	different	JJ
cord-001835-0s7ok4uw	2441	8	GR	GR	NNP
cord-001835-0s7ok4uw	2441	9	mutants	mutant	NNS
cord-001835-0s7ok4uw	2441	10	in	in	IN
cord-001835-0s7ok4uw	2441	11	the	the	DT
cord-001835-0s7ok4uw	2441	12	presence	presence	NN
cord-001835-0s7ok4uw	2441	13	of	of	IN
cord-001835-0s7ok4uw	2441	14	different	different	JJ
cord-001835-0s7ok4uw	2441	15	ligands	ligand	NNS
cord-001835-0s7ok4uw	2441	16	and	and	CC
cord-001835-0s7ok4uw	2441	17	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2441	18	results	result	NNS
cord-001835-0s7ok4uw	2441	19	suggest	suggest	VBP
cord-001835-0s7ok4uw	2441	20	that	that	IN
cord-001835-0s7ok4uw	2441	21	the	the	DT
cord-001835-0s7ok4uw	2441	22	binding	binding	NN
cord-001835-0s7ok4uw	2441	23	depends	depend	VBZ
cord-001835-0s7ok4uw	2441	24	on	on	IN
cord-001835-0s7ok4uw	2441	25	DNA	dna	NN
cord-001835-0s7ok4uw	2441	26	.	.	.
cord-001835-0s7ok4uw	2442	1	Both	both	DT
cord-001835-0s7ok4uw	2442	2	GR	GR	NNP
cord-001835-0s7ok4uw	2442	3	and	and	CC
cord-001835-0s7ok4uw	2442	4	TIF2	TIF2	NNP
cord-001835-0s7ok4uw	2442	5	autocorrelation	autocorrelation	NN
cord-001835-0s7ok4uw	2442	6	curves	curve	NNS
cord-001835-0s7ok4uw	2442	7	reveal	reveal	VBP
cord-001835-0s7ok4uw	2442	8	an	an	DT
cord-001835-0s7ok4uw	2442	9	increase	increase	NN
cord-001835-0s7ok4uw	2442	10	in	in	IN
cord-001835-0s7ok4uw	2442	11	the	the	DT
cord-001835-0s7ok4uw	2442	12	bound	bind	VBN
cord-001835-0s7ok4uw	2442	13	population	population	NN
cord-001835-0s7ok4uw	2442	14	upon	upon	IN
cord-001835-0s7ok4uw	2442	15	GR	GR	NNP
cord-001835-0s7ok4uw	2442	16	activation	activation	NN
cord-001835-0s7ok4uw	2442	17	by	by	IN
cord-001835-0s7ok4uw	2442	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2442	19	agonist	agonist	NN
cord-001835-0s7ok4uw	2442	20	dexamethasone	dexamethasone	NN
cord-001835-0s7ok4uw	2442	21	(	(	-LRB-
cord-001835-0s7ok4uw	2442	22	Dex	Dex	NNP
cord-001835-0s7ok4uw	2442	23	)	)	-RRB-
cord-001835-0s7ok4uw	2442	24	.	.	.
cord-001835-0s7ok4uw	2443	1	A	a	DT
cord-001835-0s7ok4uw	2443	2	cross	cross	JJ
cord-001835-0s7ok4uw	2443	3	-	-	JJ
cord-001835-0s7ok4uw	2443	4	correlation	correlation	JJ
cord-001835-0s7ok4uw	2443	5	analysis	analysis	NN
cord-001835-0s7ok4uw	2443	6	showed	show	VBD
cord-001835-0s7ok4uw	2443	7	that	that	IN
cord-001835-0s7ok4uw	2443	8	,	,	,
cord-001835-0s7ok4uw	2443	9	as	as	IN
cord-001835-0s7ok4uw	2443	10	expected	expect	VBN
cord-001835-0s7ok4uw	2443	11	,	,	,
cord-001835-0s7ok4uw	2443	12	Dex	Dex	NNP
cord-001835-0s7ok4uw	2443	13	-	-	HYPH
cord-001835-0s7ok4uw	2443	14	stimulus	stimulus	NN
cord-001835-0s7ok4uw	2443	15	increases	increase	VBZ
cord-001835-0s7ok4uw	2443	16	the	the	DT
cord-001835-0s7ok4uw	2443	17	population	population	NN
cord-001835-0s7ok4uw	2443	18	of	of	IN
cord-001835-0s7ok4uw	2443	19	GR	GR	NNP
cord-001835-0s7ok4uw	2443	20	-	-	HYPH
cord-001835-0s7ok4uw	2443	21	TIF2	TIF2	NNP
cord-001835-0s7ok4uw	2443	22	complexes	complex	NNS
cord-001835-0s7ok4uw	2443	23	.	.	.
cord-001835-0s7ok4uw	2444	1	Without	without	IN
cord-001835-0s7ok4uw	2444	2	hormone	hormone	NN
cord-001835-0s7ok4uw	2444	3	,	,	,
cord-001835-0s7ok4uw	2444	4	GR	GR	NNP
cord-001835-0s7ok4uw	2444	5	shows	show	VBZ
cord-001835-0s7ok4uw	2444	6	a	a	DT
cord-001835-0s7ok4uw	2444	7	homogeneous	homogeneous	JJ
cord-001835-0s7ok4uw	2444	8	distribution	distribution	NN
cord-001835-0s7ok4uw	2444	9	and	and	CC
cord-001835-0s7ok4uw	2444	10	TIF2	TIF2	NNP
cord-001835-0s7ok4uw	2444	11	forms	form	VBZ
cord-001835-0s7ok4uw	2444	12	large	large	JJ
cord-001835-0s7ok4uw	2444	13	clusters	cluster	NNS
cord-001835-0s7ok4uw	2444	14	in	in	IN
cord-001835-0s7ok4uw	2444	15	the	the	DT
cord-001835-0s7ok4uw	2444	16	nucleus	nucleus	NN
cord-001835-0s7ok4uw	2444	17	.	.	.
cord-001835-0s7ok4uw	2445	1	Upon	upon	IN
cord-001835-0s7ok4uw	2445	2	Dex	Dex	NNP
cord-001835-0s7ok4uw	2445	3	-	-	HYPH
cord-001835-0s7ok4uw	2445	4	binding	binding	NN
cord-001835-0s7ok4uw	2445	5	,	,	,
cord-001835-0s7ok4uw	2445	6	GR	GR	NNP
cord-001835-0s7ok4uw	2445	7	accumulates	accumulate	VBZ
cord-001835-0s7ok4uw	2445	8	in	in	IN
cord-001835-0s7ok4uw	2445	9	the	the	DT
cord-001835-0s7ok4uw	2445	10	nucleus	nucleus	NN
cord-001835-0s7ok4uw	2445	11	,	,	,
cord-001835-0s7ok4uw	2445	12	is	be	VBZ
cord-001835-0s7ok4uw	2445	13	rapidly	rapidly	RB
cord-001835-0s7ok4uw	2445	14	recruited	recruit	VBN
cord-001835-0s7ok4uw	2445	15	to	to	IN
cord-001835-0s7ok4uw	2445	16	TIF2	TIF2	NNP
cord-001835-0s7ok4uw	2445	17	foci	foci	NN
cord-001835-0s7ok4uw	2445	18	and	and	CC
cord-001835-0s7ok4uw	2445	19	there	there	EX
cord-001835-0s7ok4uw	2445	20	is	be	VBZ
cord-001835-0s7ok4uw	2445	21	an	an	DT
cord-001835-0s7ok4uw	2445	22	important	important	JJ
cord-001835-0s7ok4uw	2445	23	re	re	NN
cord-001835-0s7ok4uw	2445	24	-	-	NN
cord-001835-0s7ok4uw	2445	25	distribution	distribution	NN
cord-001835-0s7ok4uw	2445	26	of	of	IN
cord-001835-0s7ok4uw	2445	27	both	both	DT
cord-001835-0s7ok4uw	2445	28	proteins	protein	NNS
cord-001835-0s7ok4uw	2445	29	,	,	,
cord-001835-0s7ok4uw	2445	30	that	that	WDT
cord-001835-0s7ok4uw	2445	31	co	co	NN
cord-001835-0s7ok4uw	2445	32	-	-	VB
cord-001835-0s7ok4uw	2445	33	localize	localize	VB
cord-001835-0s7ok4uw	2445	34	in	in	IN
cord-001835-0s7ok4uw	2445	35	the	the	DT
cord-001835-0s7ok4uw	2445	36	same	same	JJ
cord-001835-0s7ok4uw	2445	37	pattern	pattern	NN
cord-001835-0s7ok4uw	2445	38	of	of	IN
cord-001835-0s7ok4uw	2445	39	small	small	JJ
cord-001835-0s7ok4uw	2445	40	intranuclear	intranuclear	NN
cord-001835-0s7ok4uw	2445	41	clusters	cluster	NNS
cord-001835-0s7ok4uw	2445	42	.	.	.
cord-001835-0s7ok4uw	2446	1	The	the	DT
cord-001835-0s7ok4uw	2446	2	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2446	3	of	of	IN
cord-001835-0s7ok4uw	2446	4	GR	GR	NNP
cord-001835-0s7ok4uw	2446	5	and	and	CC
cord-001835-0s7ok4uw	2446	6	TIF2	TIF2	NNP
cord-001835-0s7ok4uw	2446	7	molecules	molecule	NNS
cord-001835-0s7ok4uw	2446	8	at	at	IN
cord-001835-0s7ok4uw	2446	9	these	these	DT
cord-001835-0s7ok4uw	2446	10	clusters	cluster	NNS
cord-001835-0s7ok4uw	2446	11	were	be	VBD
cord-001835-0s7ok4uw	2446	12	studied	study	VBN
cord-001835-0s7ok4uw	2446	13	by	by	IN
cord-001835-0s7ok4uw	2446	14	performing	perform	VBG
cord-001835-0s7ok4uw	2446	15	orbital	orbital	JJ
cord-001835-0s7ok4uw	2446	16	-	-	HYPH
cord-001835-0s7ok4uw	2446	17	scanning	scanning	NN
cord-001835-0s7ok4uw	2446	18	measurements	measurement	NNS
cord-001835-0s7ok4uw	2446	19	,	,	,
cord-001835-0s7ok4uw	2446	20	tracking	track	VBG
cord-001835-0s7ok4uw	2446	21	the	the	DT
cord-001835-0s7ok4uw	2446	22	clusters	cluster	NNS
cord-001835-0s7ok4uw	2446	23	position	position	VBP
cord-001835-0s7ok4uw	2446	24	in	in	IN
cord-001835-0s7ok4uw	2446	25	silico	silico	NN
cord-001835-0s7ok4uw	2446	26	and	and	CC
cord-001835-0s7ok4uw	2446	27	analyzing	analyze	VBG
cord-001835-0s7ok4uw	2446	28	the	the	DT
cord-001835-0s7ok4uw	2446	29	intensity	intensity	NN
cord-001835-0s7ok4uw	2446	30	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	2446	31	of	of	IN
cord-001835-0s7ok4uw	2446	32	the	the	DT
cord-001835-0s7ok4uw	2446	33	clusters	cluster	NNS
cord-001835-0s7ok4uw	2446	34	along	along	IN
cord-001835-0s7ok4uw	2446	35	time	time	NN
cord-001835-0s7ok4uw	2446	36	.	.	.
cord-001835-0s7ok4uw	2447	1	A	a	DT
cord-001835-0s7ok4uw	2447	2	positive	positive	JJ
cord-001835-0s7ok4uw	2447	3	cross	cross	NN
cord-001835-0s7ok4uw	2447	4	-	-	NN
cord-001835-0s7ok4uw	2447	5	correlation	correlation	NN
cord-001835-0s7ok4uw	2447	6	between	between	IN
cord-001835-0s7ok4uw	2447	7	both	both	DT
cord-001835-0s7ok4uw	2447	8	channels	channel	NNS
cord-001835-0s7ok4uw	2447	9	indicates	indicate	VBZ
cord-001835-0s7ok4uw	2447	10	that	that	IN
cord-001835-0s7ok4uw	2447	11	Dex	Dex	NNP
cord-001835-0s7ok4uw	2447	12	-	-	HYPH
cord-001835-0s7ok4uw	2447	13	bound	bind	VBN
cord-001835-0s7ok4uw	2447	14	GR	GR	NNP
cord-001835-0s7ok4uw	2447	15	and	and	CC
cord-001835-0s7ok4uw	2447	16	TIF2	TIF2	NNP
cord-001835-0s7ok4uw	2447	17	interact	interact	VBP
cord-001835-0s7ok4uw	2447	18	at	at	IN
cord-001835-0s7ok4uw	2447	19	these	these	DT
cord-001835-0s7ok4uw	2447	20	foci	focus	NNS
cord-001835-0s7ok4uw	2447	21	and	and	CC
cord-001835-0s7ok4uw	2447	22	dissociate	dissociate	VB
cord-001835-0s7ok4uw	2447	23	from	from	IN
cord-001835-0s7ok4uw	2447	24	them	-PRON-	PRP
cord-001835-0s7ok4uw	2447	25	forming	form	VBG
cord-001835-0s7ok4uw	2447	26	TIF2-GR	TIF2-GR	NNP
cord-001835-0s7ok4uw	2447	27	hetero	hetero	NNS
cord-001835-0s7ok4uw	2447	28	-	-	NNS
cord-001835-0s7ok4uw	2447	29	complexes	complex	NNS
cord-001835-0s7ok4uw	2447	30	.	.	.
cord-001835-0s7ok4uw	2448	1	In	in	IN
cord-001835-0s7ok4uw	2448	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	2448	3	,	,	,
cord-001835-0s7ok4uw	2448	4	advanced	advanced	JJ
cord-001835-0s7ok4uw	2448	5	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2448	6	microscopy	microscopy	NN
cord-001835-0s7ok4uw	2448	7	methods	method	NNS
cord-001835-0s7ok4uw	2448	8	allowed	allow	VBN
cord-001835-0s7ok4uw	2448	9	obtaining	obtain	VBG
cord-001835-0s7ok4uw	2448	10	a	a	DT
cord-001835-0s7ok4uw	2448	11	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	2448	12	map	map	NN
cord-001835-0s7ok4uw	2448	13	of	of	IN
cord-001835-0s7ok4uw	2448	14	GR	GR	NNP
cord-001835-0s7ok4uw	2448	15	distribution	distribution	NN
cord-001835-0s7ok4uw	2448	16	and	and	CC
cord-001835-0s7ok4uw	2448	17	function	function	NN
cord-001835-0s7ok4uw	2448	18	in	in	IN
cord-001835-0s7ok4uw	2448	19	the	the	DT
cord-001835-0s7ok4uw	2448	20	nucleus	nucleus	NN
cord-001835-0s7ok4uw	2448	21	of	of	IN
cord-001835-0s7ok4uw	2448	22	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	2448	23	living	living	NN
cord-001835-0s7ok4uw	2448	24	cells	cell	NNS
cord-001835-0s7ok4uw	2448	25	.	.	.
cord-001835-0s7ok4uw	2449	1	Assembly	assembly	NN
cord-001835-0s7ok4uw	2449	2	of	of	IN
cord-001835-0s7ok4uw	2449	3	membrane	membrane	NN
cord-001835-0s7ok4uw	2449	4	pores	pore	NNS
cord-001835-0s7ok4uw	2449	5	as	as	IN
cord-001835-0s7ok4uw	2449	6	a	a	DT
cord-001835-0s7ok4uw	2449	7	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2449	8	for	for	IN
cord-001835-0s7ok4uw	2449	9	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2449	10	cytotoxicity	cytotoxicity	NN
cord-001835-0s7ok4uw	2449	11	by	by	IN
cord-001835-0s7ok4uw	2449	12	the	the	DT
cord-001835-0s7ok4uw	2449	13	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	2449	14	prionoid	prionoid	NN
cord-001835-0s7ok4uw	2449	15	RepA	repa	NN
cord-001835-0s7ok4uw	2449	16	-	-	HYPH
cord-001835-0s7ok4uw	2449	17	WH1	WH1	NNP
cord-001835-0s7ok4uw	2449	18	Cristina	Cristina	NNP
cord-001835-0s7ok4uw	2449	19	Fern	Fern	NNP
cord-001835-0s7ok4uw	2450	1	andez	andez	NNP
cord-001835-0s7ok4uw	2450	2	1	1	CD
cord-001835-0s7ok4uw	2450	3	,	,	,
cord-001835-0s7ok4uw	2450	4	Rafael	Rafael	NNP
cord-001835-0s7ok4uw	2450	5	N	n	CD
cord-001835-0s7ok4uw	2450	6	uñez	uñez	NNP
cord-001835-0s7ok4uw	2450	7	-	-	:
cord-001835-0s7ok4uw	2450	8	Ramirez	Ramirez	NNP
cord-001835-0s7ok4uw	2450	9	1	1	CD
cord-001835-0s7ok4uw	2450	10	,	,	,
cord-001835-0s7ok4uw	2450	11	Mercedes	Mercedes	NNP
cord-001835-0s7ok4uw	2450	12	Jimenez	Jimenez	NNP
cord-001835-0s7ok4uw	2450	13	1	1	CD
cord-001835-0s7ok4uw	2450	14	,	,	,
cord-001835-0s7ok4uw	2451	1	Germ	Germ	NNP
cord-001835-0s7ok4uw	2451	2	an	an	DT
cord-001835-0s7ok4uw	2451	3	Rivas	Rivas	NNP
cord-001835-0s7ok4uw	2451	4	1	1	CD
cord-001835-0s7ok4uw	2451	5	,	,	,
cord-001835-0s7ok4uw	2451	6	Rafael	Rafael	NNP
cord-001835-0s7ok4uw	2451	7	Giraldo	Giraldo	NNP
cord-001835-0s7ok4uw	2452	1	1	1	CD
cord-001835-0s7ok4uw	2452	2	1	1	CD
cord-001835-0s7ok4uw	2452	3	Amyloid	Amyloid	NNP
cord-001835-0s7ok4uw	2452	4	fibril	fibril	NN
cord-001835-0s7ok4uw	2452	5	formation	formation	NN
cord-001835-0s7ok4uw	2452	6	is	be	VBZ
cord-001835-0s7ok4uw	2452	7	associated	associate	VBN
cord-001835-0s7ok4uw	2452	8	with	with	IN
cord-001835-0s7ok4uw	2452	9	human	human	JJ
cord-001835-0s7ok4uw	2452	10	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	2452	11	diseases	disease	NNS
cord-001835-0s7ok4uw	2452	12	.	.	.
cord-001835-0s7ok4uw	2453	1	Prefibrillar	Prefibrillar	NNP
cord-001835-0s7ok4uw	2453	2	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2453	3	formed	form	VBN
cord-001835-0s7ok4uw	2453	4	during	during	IN
cord-001835-0s7ok4uw	2453	5	the	the	DT
cord-001835-0s7ok4uw	2453	6	fibril	fibril	NNP
cord-001835-0s7ok4uw	2453	7	assembly	assembly	NN
cord-001835-0s7ok4uw	2453	8	process	process	NN
cord-001835-0s7ok4uw	2453	9	,	,	,
cord-001835-0s7ok4uw	2453	10	rather	rather	RB
cord-001835-0s7ok4uw	2453	11	than	than	IN
cord-001835-0s7ok4uw	2453	12	mature	mature	JJ
cord-001835-0s7ok4uw	2453	13	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2453	14	are	be	VBP
cord-001835-0s7ok4uw	2453	15	known	know	VBN
cord-001835-0s7ok4uw	2453	16	to	to	TO
cord-001835-0s7ok4uw	2453	17	be	be	VB
cord-001835-0s7ok4uw	2453	18	central	central	JJ
cord-001835-0s7ok4uw	2453	19	to	to	TO
cord-001835-0s7ok4uw	2453	20	disease	disease	NN
cord-001835-0s7ok4uw	2453	21	ABSTRACT	ABSTRACT	NNP
cord-001835-0s7ok4uw	2453	22	and	and	CC
cord-001835-0s7ok4uw	2453	23	may	may	MD
cord-001835-0s7ok4uw	2453	24	be	be	VB
cord-001835-0s7ok4uw	2453	25	responsible	responsible	JJ
cord-001835-0s7ok4uw	2453	26	for	for	IN
cord-001835-0s7ok4uw	2453	27	cell	cell	NN
cord-001835-0s7ok4uw	2453	28	damage	damage	NN
cord-001835-0s7ok4uw	2453	29	.	.	.
cord-001835-0s7ok4uw	2454	1	A	a	DT
cord-001835-0s7ok4uw	2454	2	commonly	commonly	RB
cord-001835-0s7ok4uw	2454	3	proposed	propose	VBN
cord-001835-0s7ok4uw	2454	4	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2454	5	for	for	IN
cord-001835-0s7ok4uw	2454	6	the	the	DT
cord-001835-0s7ok4uw	2454	7	toxicity	toxicity	NN
cord-001835-0s7ok4uw	2454	8	of	of	IN
cord-001835-0s7ok4uw	2454	9	small	small	JJ
cord-001835-0s7ok4uw	2454	10	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	2454	11	is	be	VBZ
cord-001835-0s7ok4uw	2454	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2454	13	interaction	interaction	NN
cord-001835-0s7ok4uw	2454	14	with	with	IN
cord-001835-0s7ok4uw	2454	15	the	the	DT
cord-001835-0s7ok4uw	2454	16	lipid	lipid	NN
cord-001835-0s7ok4uw	2454	17	bilayer	bilayer	NN
cord-001835-0s7ok4uw	2454	18	of	of	IN
cord-001835-0s7ok4uw	2454	19	cell	cell	NN
cord-001835-0s7ok4uw	2454	20	membranes	membrane	NNS
cord-001835-0s7ok4uw	2454	21	,	,	,
cord-001835-0s7ok4uw	2454	22	leading	lead	VBG
cord-001835-0s7ok4uw	2454	23	to	to	IN
cord-001835-0s7ok4uw	2454	24	loss	loss	NN
cord-001835-0s7ok4uw	2454	25	of	of	IN
cord-001835-0s7ok4uw	2454	26	membrane	membrane	NN
cord-001835-0s7ok4uw	2454	27	integrity	integrity	NN
cord-001835-0s7ok4uw	2454	28	[	[	-LRB-
cord-001835-0s7ok4uw	2454	29	1	1	CD
cord-001835-0s7ok4uw	2454	30	]	]	-RRB-
cord-001835-0s7ok4uw	2454	31	.	.	.
cord-001835-0s7ok4uw	2455	1	Recent	recent	JJ
cord-001835-0s7ok4uw	2455	2	studies	study	NNS
cord-001835-0s7ok4uw	2455	3	from	from	IN
cord-001835-0s7ok4uw	2455	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2455	5	laboratory	laboratory	NN
cord-001835-0s7ok4uw	2455	6	have	have	VBP
cord-001835-0s7ok4uw	2455	7	shown	show	VBN
cord-001835-0s7ok4uw	2455	8	that	that	IN
cord-001835-0s7ok4uw	2455	9	RepA	repa	NN
cord-001835-0s7ok4uw	2455	10	-	-	HYPH
cord-001835-0s7ok4uw	2455	11	WH1	WH1	NNP
cord-001835-0s7ok4uw	2455	12	,	,	,
cord-001835-0s7ok4uw	2455	13	a	a	DT
cord-001835-0s7ok4uw	2455	14	winged	winged	JJ
cord-001835-0s7ok4uw	2455	15	-	-	HYPH
cord-001835-0s7ok4uw	2455	16	helix	helix	NN
cord-001835-0s7ok4uw	2455	17	domain	domain	NN
cord-001835-0s7ok4uw	2455	18	from	from	IN
cord-001835-0s7ok4uw	2455	19	a	a	DT
cord-001835-0s7ok4uw	2455	20	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	2455	21	plasmid	plasmid	NN
cord-001835-0s7ok4uw	2455	22	replication	replication	NN
cord-001835-0s7ok4uw	2455	23	protein	protein	NN
cord-001835-0s7ok4uw	2455	24	,	,	,
cord-001835-0s7ok4uw	2455	25	can	can	MD
cord-001835-0s7ok4uw	2455	26	assemble	assemble	VB
cord-001835-0s7ok4uw	2455	27	into	into	IN
cord-001835-0s7ok4uw	2455	28	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2455	29	fibrils	fibril	NNS
cord-001835-0s7ok4uw	2455	30	in	in	IN
cord-001835-0s7ok4uw	2455	31	vitro	vitro	FW
cord-001835-0s7ok4uw	2455	32	.	.	.
cord-001835-0s7ok4uw	2456	1	When	when	WRB
cord-001835-0s7ok4uw	2456	2	expressed	express	VBN
cord-001835-0s7ok4uw	2456	3	in	in	IN
cord-001835-0s7ok4uw	2456	4	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	2456	5	coli	coli	NNS
cord-001835-0s7ok4uw	2456	6	RepA	repa	NN
cord-001835-0s7ok4uw	2456	7	-	-	HYPH
cord-001835-0s7ok4uw	2456	8	WH1	wh1	NN
cord-001835-0s7ok4uw	2456	9	functions	function	NNS
cord-001835-0s7ok4uw	2456	10	as	as	IN
cord-001835-0s7ok4uw	2456	11	a	a	DT
cord-001835-0s7ok4uw	2456	12	cytotoxic	cytotoxic	JJ
cord-001835-0s7ok4uw	2456	13	protein	protein	NN
cord-001835-0s7ok4uw	2456	14	that	that	WDT
cord-001835-0s7ok4uw	2456	15	shares	share	VBZ
cord-001835-0s7ok4uw	2456	16	features	feature	VBZ
cord-001835-0s7ok4uw	2456	17	with	with	IN
cord-001835-0s7ok4uw	2456	18	the	the	DT
cord-001835-0s7ok4uw	2456	19	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	2456	20	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2456	21	proteinopathies	proteinopathie	NNS
cord-001835-0s7ok4uw	2456	22	.	.	.
cord-001835-0s7ok4uw	2457	1	These	these	DT
cord-001835-0s7ok4uw	2457	2	features	feature	NNS
cord-001835-0s7ok4uw	2457	3	have	have	VBP
cord-001835-0s7ok4uw	2457	4	proved	prove	VBN
cord-001835-0s7ok4uw	2457	5	RepA	repa	NN
cord-001835-0s7ok4uw	2457	6	-	-	HYPH
cord-001835-0s7ok4uw	2457	7	WH1	wh1	NN
cord-001835-0s7ok4uw	2457	8	to	to	TO
cord-001835-0s7ok4uw	2457	9	be	be	VB
cord-001835-0s7ok4uw	2457	10	a	a	DT
cord-001835-0s7ok4uw	2457	11	suitable	suitable	JJ
cord-001835-0s7ok4uw	2457	12	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	2457	13	model	model	NN
cord-001835-0s7ok4uw	2457	14	system	system	NN
cord-001835-0s7ok4uw	2457	15	to	to	TO
cord-001835-0s7ok4uw	2457	16	study	study	VB
cord-001835-0s7ok4uw	2457	17	protein	protein	NN
cord-001835-0s7ok4uw	2457	18	amyloidosis	amyloidosis	NN
cord-001835-0s7ok4uw	2457	19	[	[	-LRB-
cord-001835-0s7ok4uw	2457	20	2	2	CD
cord-001835-0s7ok4uw	2457	21	,	,	,
cord-001835-0s7ok4uw	2457	22	3	3	CD
cord-001835-0s7ok4uw	2457	23	,	,	,
cord-001835-0s7ok4uw	2457	24	4	4	CD
cord-001835-0s7ok4uw	2457	25	]	]	-RRB-
cord-001835-0s7ok4uw	2457	26	.	.	.
cord-001835-0s7ok4uw	2458	1	In	in	IN
cord-001835-0s7ok4uw	2458	2	this	this	DT
cord-001835-0s7ok4uw	2458	3	work	work	NN
cord-001835-0s7ok4uw	2458	4	,	,	,
cord-001835-0s7ok4uw	2458	5	using	use	VBG
cord-001835-0s7ok4uw	2458	6	the	the	DT
cord-001835-0s7ok4uw	2458	7	RepA	RepA	NNP
cord-001835-0s7ok4uw	2458	8	-	-	HYPH
cord-001835-0s7ok4uw	2458	9	WH1	wh1	NN
cord-001835-0s7ok4uw	2458	10	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	2458	11	model	model	NN
cord-001835-0s7ok4uw	2458	12	system	system	NN
cord-001835-0s7ok4uw	2458	13	,	,	,
cord-001835-0s7ok4uw	2458	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	2458	15	have	have	VBP
cord-001835-0s7ok4uw	2458	16	studied	study	VBN
cord-001835-0s7ok4uw	2458	17	the	the	DT
cord-001835-0s7ok4uw	2458	18	interaction	interaction	NN
cord-001835-0s7ok4uw	2458	19	between	between	IN
cord-001835-0s7ok4uw	2458	20	the	the	DT
cord-001835-0s7ok4uw	2458	21	protein	protein	NN
cord-001835-0s7ok4uw	2458	22	and	and	CC
cord-001835-0s7ok4uw	2458	23	model	model	NN
cord-001835-0s7ok4uw	2458	24	membranes	membrane	NNS
cord-001835-0s7ok4uw	2458	25	(	(	-LRB-
cord-001835-0s7ok4uw	2458	26	large	large	JJ
cord-001835-0s7ok4uw	2458	27	and	and	CC
cord-001835-0s7ok4uw	2458	28	giant	giant	JJ
cord-001835-0s7ok4uw	2458	29	unilamellar	unilamellar	JJ
cord-001835-0s7ok4uw	2458	30	lipid	lipid	NN
cord-001835-0s7ok4uw	2458	31	vesicles	vesicle	NNS
cord-001835-0s7ok4uw	2458	32	,	,	,
cord-001835-0s7ok4uw	2458	33	LUVs	luv	NNS
cord-001835-0s7ok4uw	2458	34	,	,	,
cord-001835-0s7ok4uw	2458	35	and	and	CC
cord-001835-0s7ok4uw	2458	36	GUVs	GUVs	NNP
cord-001835-0s7ok4uw	2458	37	respectively	respectively	RB
cord-001835-0s7ok4uw	2458	38	)	)	-RRB-
cord-001835-0s7ok4uw	2458	39	.	.	.
cord-001835-0s7ok4uw	2459	1	RepA	repa	NN
cord-001835-0s7ok4uw	2459	2	-	-	HYPH
cord-001835-0s7ok4uw	2459	3	WH1	wh1	NN
cord-001835-0s7ok4uw	2459	4	shows	show	VBZ
cord-001835-0s7ok4uw	2459	5	association	association	NN
cord-001835-0s7ok4uw	2459	6	and	and	CC
cord-001835-0s7ok4uw	2459	7	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2459	8	to	to	IN
cord-001835-0s7ok4uw	2459	9	membranes	membrane	NNS
cord-001835-0s7ok4uw	2459	10	composed	compose	VBN
cord-001835-0s7ok4uw	2459	11	of	of	IN
cord-001835-0s7ok4uw	2459	12	anionic	anionic	JJ
cord-001835-0s7ok4uw	2459	13	phospholipids	phospholipid	NNS
cord-001835-0s7ok4uw	2459	14	.	.	.
cord-001835-0s7ok4uw	2460	1	Protein	Protein	NNP
cord-001835-0s7ok4uw	2460	2	association	association	NN
cord-001835-0s7ok4uw	2460	3	in	in	IN
cord-001835-0s7ok4uw	2460	4	GUVs	GUVs	NNP
cord-001835-0s7ok4uw	2460	5	did	do	VBD
cord-001835-0s7ok4uw	2460	6	not	not	RB
cord-001835-0s7ok4uw	2460	7	result	result	VB
cord-001835-0s7ok4uw	2460	8	in	in	IN
cord-001835-0s7ok4uw	2460	9	lysis	lysis	NN
cord-001835-0s7ok4uw	2460	10	of	of	IN
cord-001835-0s7ok4uw	2460	11	the	the	DT
cord-001835-0s7ok4uw	2460	12	vesicles	vesicle	NNS
cord-001835-0s7ok4uw	2460	13	,	,	,
cord-001835-0s7ok4uw	2460	14	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2460	15	the	the	DT
cord-001835-0s7ok4uw	2460	16	assembly	assembly	NN
cord-001835-0s7ok4uw	2460	17	of	of	IN
cord-001835-0s7ok4uw	2460	18	discrete	discrete	JJ
cord-001835-0s7ok4uw	2460	19	protein	protein	NN
cord-001835-0s7ok4uw	2460	20	pores	pore	NNS
cord-001835-0s7ok4uw	2460	21	as	as	IN
cord-001835-0s7ok4uw	2460	22	the	the	DT
cord-001835-0s7ok4uw	2460	23	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2460	24	for	for	IN
cord-001835-0s7ok4uw	2460	25	RepA	repa	NN
cord-001835-0s7ok4uw	2460	26	-	-	HYPH
cord-001835-0s7ok4uw	2460	27	WH1	wh1	NN
cord-001835-0s7ok4uw	2460	28	membrane	membrane	NN
cord-001835-0s7ok4uw	2460	29	damage	damage	NN
cord-001835-0s7ok4uw	2460	30	.	.	.
cord-001835-0s7ok4uw	2461	1	To	to	TO
cord-001835-0s7ok4uw	2461	2	investigate	investigate	VB
cord-001835-0s7ok4uw	2461	3	the	the	DT
cord-001835-0s7ok4uw	2461	4	formation	formation	NN
cord-001835-0s7ok4uw	2461	5	of	of	IN
cord-001835-0s7ok4uw	2461	6	pores	pore	NNS
cord-001835-0s7ok4uw	2461	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	2461	8	analyzed	analyze	VBN
cord-001835-0s7ok4uw	2461	9	by	by	IN
cord-001835-0s7ok4uw	2461	10	electron	electron	NN
cord-001835-0s7ok4uw	2461	11	microscopy	microscopy	VBP
cord-001835-0s7ok4uw	2461	12	the	the	DT
cord-001835-0s7ok4uw	2461	13	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2461	14	of	of	IN
cord-001835-0s7ok4uw	2461	15	RepA	repa	NN
cord-001835-0s7ok4uw	2461	16	-	-	HYPH
cord-001835-0s7ok4uw	2461	17	WH1	wh1	NN
cord-001835-0s7ok4uw	2461	18	in	in	IN
cord-001835-0s7ok4uw	2461	19	the	the	DT
cord-001835-0s7ok4uw	2461	20	presence	presence	NN
cord-001835-0s7ok4uw	2461	21	of	of	IN
cord-001835-0s7ok4uw	2461	22	a	a	DT
cord-001835-0s7ok4uw	2461	23	pre	pre	JJ
cord-001835-0s7ok4uw	2461	24	-	-	JJ
cord-001835-0s7ok4uw	2461	25	formed	form	VBN
cord-001835-0s7ok4uw	2461	26	E.	E.	NNP
cord-001835-0s7ok4uw	2461	27	coli	coli	NN
cord-001835-0s7ok4uw	2461	28	lipid	lipid	NN
cord-001835-0s7ok4uw	2461	29	monolayer	monolayer	NN
cord-001835-0s7ok4uw	2461	30	.	.	.
cord-001835-0s7ok4uw	2462	1	The	the	DT
cord-001835-0s7ok4uw	2462	2	EM	EM	NNP
cord-001835-0s7ok4uw	2462	3	images	image	NNS
cord-001835-0s7ok4uw	2462	4	show	show	VBP
cord-001835-0s7ok4uw	2462	5	the	the	DT
cord-001835-0s7ok4uw	2462	6	presence	presence	NN
cord-001835-0s7ok4uw	2462	7	of	of	IN
cord-001835-0s7ok4uw	2462	8	pore	pore	NN
cord-001835-0s7ok4uw	2462	9	-	-	HYPH
cord-001835-0s7ok4uw	2462	10	like	like	JJ
cord-001835-0s7ok4uw	2462	11	particles	particle	NNS
cord-001835-0s7ok4uw	2462	12	on	on	IN
cord-001835-0s7ok4uw	2462	13	the	the	DT
cord-001835-0s7ok4uw	2462	14	monolayer	monolayer	NN
cord-001835-0s7ok4uw	2462	15	.	.	.
cord-001835-0s7ok4uw	2463	1	Amyloid	amyloid	NN
cord-001835-0s7ok4uw	2463	2	pores	pore	NNS
cord-001835-0s7ok4uw	2464	1	formation	formation	NN
cord-001835-0s7ok4uw	2464	2	explains	explain	VBZ
cord-001835-0s7ok4uw	2464	3	the	the	DT
cord-001835-0s7ok4uw	2464	4	permeabilization	permeabilization	NN
cord-001835-0s7ok4uw	2464	5	effect	effect	NN
cord-001835-0s7ok4uw	2464	6	of	of	IN
cord-001835-0s7ok4uw	2464	7	RepA	repa	NN
cord-001835-0s7ok4uw	2464	8	-	-	HYPH
cord-001835-0s7ok4uw	2464	9	WH1	wh1	NN
cord-001835-0s7ok4uw	2464	10	in	in	IN
cord-001835-0s7ok4uw	2464	11	vesicle	vesicle	NN
cord-001835-0s7ok4uw	2464	12	models	model	NNS
cord-001835-0s7ok4uw	2464	13	and	and	CC
cord-001835-0s7ok4uw	2464	14	is	be	VBZ
cord-001835-0s7ok4uw	2464	15	in	in	IN
cord-001835-0s7ok4uw	2464	16	agreement	agreement	NN
cord-001835-0s7ok4uw	2464	17	with	with	IN
cord-001835-0s7ok4uw	2464	18	observations	observation	NNS
cord-001835-0s7ok4uw	2464	19	for	for	IN
cord-001835-0s7ok4uw	2464	20	human	human	JJ
cord-001835-0s7ok4uw	2464	21	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	2464	22	proteins	protein	NNS
cord-001835-0s7ok4uw	2464	23	.	.	.
cord-001835-0s7ok4uw	2465	1	The	the	DT
cord-001835-0s7ok4uw	2465	2	approaches	approach	NNS
cord-001835-0s7ok4uw	2465	3	presented	present	VBN
cord-001835-0s7ok4uw	2465	4	here	here	RB
cord-001835-0s7ok4uw	2465	5	provide	provide	VB
cord-001835-0s7ok4uw	2465	6	a	a	DT
cord-001835-0s7ok4uw	2465	7	deeper	deep	JJR
cord-001835-0s7ok4uw	2465	8	insight	insight	NN
cord-001835-0s7ok4uw	2465	9	into	into	IN
cord-001835-0s7ok4uw	2465	10	amyloid	amyloid	NN
cord-001835-0s7ok4uw	2465	11	cytotoxicity	cytotoxicity	NN
cord-001835-0s7ok4uw	2465	12	towards	towards	IN
cord-001835-0s7ok4uw	2465	13	membranes	membrane	NNS
cord-001835-0s7ok4uw	2465	14	and	and	CC
cord-001835-0s7ok4uw	2465	15	will	will	MD
cord-001835-0s7ok4uw	2465	16	make	make	VB
cord-001835-0s7ok4uw	2465	17	possible	possible	JJ
cord-001835-0s7ok4uw	2465	18	the	the	DT
cord-001835-0s7ok4uw	2465	19	assay	assay	NN
cord-001835-0s7ok4uw	2465	20	of	of	IN
cord-001835-0s7ok4uw	2465	21	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	2465	22	and	and	CC
cord-001835-0s7ok4uw	2465	23	effectors	effector	NNS
cord-001835-0s7ok4uw	2465	24	of	of	IN
cord-001835-0s7ok4uw	2465	25	amyloidosis	amyloidosis	NN
cord-001835-0s7ok4uw	2465	26	under	under	IN
cord-001835-0s7ok4uw	2465	27	controlled	control	VBN
cord-001835-0s7ok4uw	2465	28	conditions	condition	NNS
cord-001835-0s7ok4uw	2465	29	.	.	.
cord-001835-0s7ok4uw	2466	1	References	reference	NNS
cord-001835-0s7ok4uw	2466	2	:	:	:
cord-001835-0s7ok4uw	2467	1	b2-adrenergic	b2-adrenergic	JJ
cord-001835-0s7ok4uw	2467	2	receptor	receptor	NN
cord-001835-0s7ok4uw	2467	3	(	(	-LRB-
cord-001835-0s7ok4uw	2467	4	b2AR	b2AR	NNP
cord-001835-0s7ok4uw	2467	5	)	)	-RRB-
cord-001835-0s7ok4uw	2467	6	is	be	VBZ
cord-001835-0s7ok4uw	2467	7	a	a	DT
cord-001835-0s7ok4uw	2467	8	member	member	NN
cord-001835-0s7ok4uw	2467	9	of	of	IN
cord-001835-0s7ok4uw	2467	10	G	g	NN
cord-001835-0s7ok4uw	2467	11	protein	protein	NN
cord-001835-0s7ok4uw	2467	12	-	-	HYPH
cord-001835-0s7ok4uw	2467	13	coupled	couple	VBN
cord-001835-0s7ok4uw	2467	14	receptors	receptor	NNS
cord-001835-0s7ok4uw	2467	15	,	,	,
cord-001835-0s7ok4uw	2467	16	which	which	WDT
cord-001835-0s7ok4uw	2467	17	represent	represent	VBP
cord-001835-0s7ok4uw	2467	18	the	the	DT
cord-001835-0s7ok4uw	2467	19	single	single	JJ
cord-001835-0s7ok4uw	2467	20	largest	large	JJS
cord-001835-0s7ok4uw	2467	21	family	family	NN
cord-001835-0s7ok4uw	2467	22	of	of	IN
cord-001835-0s7ok4uw	2467	23	cell	cell	NN
cord-001835-0s7ok4uw	2467	24	surface	surface	NN
cord-001835-0s7ok4uw	2467	25	receptors	receptor	NNS
cord-001835-0s7ok4uw	2467	26	involved	involve	VBN
cord-001835-0s7ok4uw	2467	27	in	in	IN
cord-001835-0s7ok4uw	2467	28	signal	signal	NN
cord-001835-0s7ok4uw	2467	29	transduction	transduction	NN
cord-001835-0s7ok4uw	2467	30	.	.	.
cord-001835-0s7ok4uw	2468	1	b2AR	b2AR	NNP
cord-001835-0s7ok4uw	2468	2	recognizes	recognize	VBZ
cord-001835-0s7ok4uw	2468	3	a	a	DT
cord-001835-0s7ok4uw	2468	4	variety	variety	NN
cord-001835-0s7ok4uw	2468	5	of	of	IN
cord-001835-0s7ok4uw	2468	6	ligands	ligand	NNS
cord-001835-0s7ok4uw	2468	7	and	and	CC
cord-001835-0s7ok4uw	2468	8	communicates	communicate	VBZ
cord-001835-0s7ok4uw	2468	9	with	with	IN
cord-001835-0s7ok4uw	2468	10	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	2468	11	G	g	NN
cord-001835-0s7ok4uw	2468	12	-	-	HYPH
cord-001835-0s7ok4uw	2468	13	proteins	protein	NNS
cord-001835-0s7ok4uw	2468	14	by	by	IN
cord-001835-0s7ok4uw	2468	15	transmitting	transmit	VBG
cord-001835-0s7ok4uw	2468	16	signals	signal	NNS
cord-001835-0s7ok4uw	2468	17	through	through	IN
cord-001835-0s7ok4uw	2468	18	the	the	DT
cord-001835-0s7ok4uw	2468	19	cellular	cellular	JJ
cord-001835-0s7ok4uw	2468	20	membrane	membrane	NN
cord-001835-0s7ok4uw	2468	21	.	.	.
cord-001835-0s7ok4uw	2469	1	Thus	thus	RB
cord-001835-0s7ok4uw	2469	2	,	,	,
cord-001835-0s7ok4uw	2469	3	investigation	investigation	NN
cord-001835-0s7ok4uw	2469	4	of	of	IN
cord-001835-0s7ok4uw	2469	5	communication	communication	NN
cord-001835-0s7ok4uw	2469	6	pathways	pathway	NNS
cord-001835-0s7ok4uw	2469	7	for	for	IN
cord-001835-0s7ok4uw	2469	8	b2AR	b2AR	NNS
cord-001835-0s7ok4uw	2469	9	may	may	MD
cord-001835-0s7ok4uw	2469	10	give	give	VB
cord-001835-0s7ok4uw	2469	11	important	important	JJ
cord-001835-0s7ok4uw	2469	12	insights	insight	NNS
cord-001835-0s7ok4uw	2469	13	for	for	IN
cord-001835-0s7ok4uw	2469	14	understanding	understand	VBG
cord-001835-0s7ok4uw	2469	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2469	16	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2469	17	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	2469	18	and	and	CC
cord-001835-0s7ok4uw	2469	19	identifying	identify	VBG
cord-001835-0s7ok4uw	2469	20	new	new	JJ
cord-001835-0s7ok4uw	2469	21	target	target	NN
cord-001835-0s7ok4uw	2469	22	sites	site	NNS
cord-001835-0s7ok4uw	2469	23	for	for	IN
cord-001835-0s7ok4uw	2469	24	more	more	RBR
cord-001835-0s7ok4uw	2469	25	specific	specific	JJ
cord-001835-0s7ok4uw	2469	26	and	and	CC
cord-001835-0s7ok4uw	2469	27	efficient	efficient	JJ
cord-001835-0s7ok4uw	2469	28	drug	drug	NN
cord-001835-0s7ok4uw	2469	29	molecules	molecule	NNS
cord-001835-0s7ok4uw	2469	30	to	to	TO
cord-001835-0s7ok4uw	2469	31	be	be	VB
cord-001835-0s7ok4uw	2469	32	used	use	VBN
cord-001835-0s7ok4uw	2469	33	in	in	IN
cord-001835-0s7ok4uw	2469	34	the	the	DT
cord-001835-0s7ok4uw	2469	35	treatment	treatment	NN
cord-001835-0s7ok4uw	2469	36	of	of	IN
cord-001835-0s7ok4uw	2469	37	pulmonary	pulmonary	JJ
cord-001835-0s7ok4uw	2469	38	and	and	CC
cord-001835-0s7ok4uw	2469	39	cardiovascular	cardiovascular	JJ
cord-001835-0s7ok4uw	2469	40	disease	disease	NN
cord-001835-0s7ok4uw	2469	41	.	.	.
cord-001835-0s7ok4uw	2470	1	In	in	IN
cord-001835-0s7ok4uw	2470	2	this	this	DT
cord-001835-0s7ok4uw	2470	3	study	study	NN
cord-001835-0s7ok4uw	2470	4	,	,	,
cord-001835-0s7ok4uw	2470	5	various	various	JJ
cord-001835-0s7ok4uw	2470	6	conformations	conformation	NNS
cord-001835-0s7ok4uw	2470	7	from	from	IN
cord-001835-0s7ok4uw	2470	8	2	2	CD
cord-001835-0s7ok4uw	2470	9	ms	ms	NNP
cord-001835-0s7ok4uw	2470	10	molecular	molecular	JJ
cord-001835-0s7ok4uw	2470	11	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2470	12	(	(	-LRB-
cord-001835-0s7ok4uw	2470	13	MD	MD	NNP
cord-001835-0s7ok4uw	2470	14	)	)	-RRB-
cord-001835-0s7ok4uw	2470	15	simulations	simulation	NNS
cord-001835-0s7ok4uw	2470	16	and	and	CC
cord-001835-0s7ok4uw	2470	17	available	available	JJ
cord-001835-0s7ok4uw	2470	18	crystal	crystal	NN
cord-001835-0s7ok4uw	2470	19	structures	structure	NNS
cord-001835-0s7ok4uw	2470	20	of	of	IN
cord-001835-0s7ok4uw	2470	21	human	human	JJ
cord-001835-0s7ok4uw	2470	22	b2AR	b2AR	NNS
cord-001835-0s7ok4uw	2470	23	were	be	VBD
cord-001835-0s7ok4uw	2470	24	investigated	investigate	VBN
cord-001835-0s7ok4uw	2470	25	to	to	TO
cord-001835-0s7ok4uw	2470	26	reveal	reveal	VB
cord-001835-0s7ok4uw	2470	27	alternative	alternative	JJ
cord-001835-0s7ok4uw	2470	28	signaling	signal	VBG
cord-001835-0s7ok4uw	2470	29	pathways	pathway	NNS
cord-001835-0s7ok4uw	2470	30	between	between	IN
cord-001835-0s7ok4uw	2470	31	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2470	32	extra	extra	JJ
cord-001835-0s7ok4uw	2470	33	and	and	CC
cord-001835-0s7ok4uw	2470	34	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	2470	35	regions	region	NNS
cord-001835-0s7ok4uw	2470	36	.	.	.
cord-001835-0s7ok4uw	2471	1	Specifically	specifically	RB
cord-001835-0s7ok4uw	2471	2	,	,	,
cord-001835-0s7ok4uw	2471	3	shortest	short	JJS
cord-001835-0s7ok4uw	2471	4	communication	communication	NN
cord-001835-0s7ok4uw	2471	5	paths	path	NNS
cord-001835-0s7ok4uw	2471	6	connecting	connect	VBG
cord-001835-0s7ok4uw	2471	7	key	key	JJ
cord-001835-0s7ok4uw	2471	8	residues	residue	NNS
cord-001835-0s7ok4uw	2471	9	(	(	-LRB-
cord-001835-0s7ok4uw	2471	10	more	more	JJR
cord-001835-0s7ok4uw	2471	11	than	than	IN
cord-001835-0s7ok4uw	2471	12	35	35	CD
cord-001835-0s7ok4uw	2471	13	Å	å	NN
cord-001835-0s7ok4uw	2471	14	apart	apart	RB
cord-001835-0s7ok4uw	2471	15	)	)	-RRB-
cord-001835-0s7ok4uw	2471	16	at	at	IN
cord-001835-0s7ok4uw	2471	17	the	the	DT
cord-001835-0s7ok4uw	2471	18	orthosteric	orthosteric	NNP
cord-001835-0s7ok4uw	2471	19	ligand	ligand	NN
cord-001835-0s7ok4uw	2471	20	binding	binding	NN
cord-001835-0s7ok4uw	2471	21	site	site	NN
cord-001835-0s7ok4uw	2471	22	(	(	-LRB-
cord-001835-0s7ok4uw	2471	23	D113	D113	NNS
cord-001835-0s7ok4uw	2471	24	,	,	,
cord-001835-0s7ok4uw	2471	25	S203	s203	NN
cord-001835-0s7ok4uw	2471	26	,	,	,
cord-001835-0s7ok4uw	2471	27	T286	T286	NNP
cord-001835-0s7ok4uw	2471	28	,	,	,
cord-001835-0s7ok4uw	2471	29	F289	F289	NNP
cord-001835-0s7ok4uw	2471	30	,	,	,
cord-001835-0s7ok4uw	2471	31	N312	N312	NNP
cord-001835-0s7ok4uw	2471	32	)	)	-RRB-
cord-001835-0s7ok4uw	2471	33	to	to	IN
cord-001835-0s7ok4uw	2471	34	either	either	CC
cord-001835-0s7ok4uw	2471	35	L266	l266	VB
cord-001835-0s7ok4uw	2471	36	or	or	CC
cord-001835-0s7ok4uw	2471	37	S329	S329	NNS
cord-001835-0s7ok4uw	2471	38	located	locate	VBN
cord-001835-0s7ok4uw	2471	39	near	near	IN
cord-001835-0s7ok4uw	2471	40	the	the	DT
cord-001835-0s7ok4uw	2471	41	G	g	NN
cord-001835-0s7ok4uw	2471	42	-	-	HYPH
cord-001835-0s7ok4uw	2471	43	protein	protein	NN
cord-001835-0s7ok4uw	2471	44	binding	binding	NN
cord-001835-0s7ok4uw	2471	45	site	site	NN
cord-001835-0s7ok4uw	2471	46	were	be	VBD
cord-001835-0s7ok4uw	2471	47	investigated	investigate	VBN
cord-001835-0s7ok4uw	2471	48	.	.	.
cord-001835-0s7ok4uw	2472	1	The	the	DT
cord-001835-0s7ok4uw	2472	2	conformers	conformer	NNS
cord-001835-0s7ok4uw	2472	3	from	from	IN
cord-001835-0s7ok4uw	2472	4	previous	previous	JJ
cord-001835-0s7ok4uw	2472	5	MD	MD	NNP
cord-001835-0s7ok4uw	2472	6	simulations	simulation	NNS
cord-001835-0s7ok4uw	2472	7	[	[	-LRB-
cord-001835-0s7ok4uw	2472	8	1	1	CD
cord-001835-0s7ok4uw	2472	9	]	]	-RRB-
cord-001835-0s7ok4uw	2472	10	include	include	VBP
cord-001835-0s7ok4uw	2472	11	the	the	DT
cord-001835-0s7ok4uw	2472	12	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	2472	13	loop	loop	NN
cord-001835-0s7ok4uw	2472	14	3	3	CD
cord-001835-0s7ok4uw	2472	15	(	(	-LRB-
cord-001835-0s7ok4uw	2472	16	ICL3	ICL3	NNP
cord-001835-0s7ok4uw	2472	17	)	)	-RRB-
cord-001835-0s7ok4uw	2472	18	,	,	,
cord-001835-0s7ok4uw	2472	19	which	which	WDT
cord-001835-0s7ok4uw	2472	20	especially	especially	RB
cord-001835-0s7ok4uw	2472	21	affects	affect	VBZ
cord-001835-0s7ok4uw	2472	22	the	the	DT
cord-001835-0s7ok4uw	2472	23	transmembrane	transmembrane	NNP
cord-001835-0s7ok4uw	2472	24	collective	collective	JJ
cord-001835-0s7ok4uw	2472	25	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2472	26	but	but	CC
cord-001835-0s7ok4uw	2472	27	is	be	VBZ
cord-001835-0s7ok4uw	2472	28	lacking	lack	VBG
cord-001835-0s7ok4uw	2472	29	in	in	IN
cord-001835-0s7ok4uw	2472	30	x	x	NN
cord-001835-0s7ok4uw	2472	31	-	-	NN
cord-001835-0s7ok4uw	2472	32	ray	ray	JJ
cord-001835-0s7ok4uw	2472	33	structures	structure	NNS
cord-001835-0s7ok4uw	2472	34	.	.	.
cord-001835-0s7ok4uw	2473	1	The	the	DT
cord-001835-0s7ok4uw	2473	2	protein	protein	NN
cord-001835-0s7ok4uw	2473	3	was	be	VBD
cord-001835-0s7ok4uw	2473	4	described	describe	VBN
cord-001835-0s7ok4uw	2473	5	as	as	IN
cord-001835-0s7ok4uw	2473	6	a	a	DT
cord-001835-0s7ok4uw	2473	7	graph	graph	NN
cord-001835-0s7ok4uw	2473	8	composed	compose	VBN
cord-001835-0s7ok4uw	2473	9	of	of	IN
cord-001835-0s7ok4uw	2473	10	nodes	node	NNS
cord-001835-0s7ok4uw	2473	11	linked	link	VBN
cord-001835-0s7ok4uw	2473	12	by	by	IN
cord-001835-0s7ok4uw	2473	13	edges	edge	NNS
cord-001835-0s7ok4uw	2473	14	.	.	.
cord-001835-0s7ok4uw	2474	1	Nodes	node	NNS
cord-001835-0s7ok4uw	2474	2	were	be	VBD
cord-001835-0s7ok4uw	2474	3	placed	place	VBN
cord-001835-0s7ok4uw	2474	4	at	at	IN
cord-001835-0s7ok4uw	2474	5	the	the	DT
cord-001835-0s7ok4uw	2474	6	alpha	alpha	NN
cord-001835-0s7ok4uw	2474	7	-	-	HYPH
cord-001835-0s7ok4uw	2474	8	carbon	carbon	NN
cord-001835-0s7ok4uw	2474	9	atoms	atom	NNS
cord-001835-0s7ok4uw	2474	10	and	and	CC
cord-001835-0s7ok4uw	2474	11	the	the	DT
cord-001835-0s7ok4uw	2474	12	edges	edge	NNS
cord-001835-0s7ok4uw	2474	13	were	be	VBD
cord-001835-0s7ok4uw	2474	14	calculated	calculate	VBN
cord-001835-0s7ok4uw	2474	15	based	base	VBN
cord-001835-0s7ok4uw	2474	16	on	on	IN
cord-001835-0s7ok4uw	2474	17	the	the	DT
cord-001835-0s7ok4uw	2474	18	number	number	NN
cord-001835-0s7ok4uw	2474	19	of	of	IN
cord-001835-0s7ok4uw	2474	20	atom	atom	NN
cord-001835-0s7ok4uw	2474	21	-	-	HYPH
cord-001835-0s7ok4uw	2474	22	atom	atom	NN
cord-001835-0s7ok4uw	2474	23	interactions	interaction	NNS
cord-001835-0s7ok4uw	2474	24	within	within	IN
cord-001835-0s7ok4uw	2474	25	a	a	DT
cord-001835-0s7ok4uw	2474	26	cut	cut	VB
cord-001835-0s7ok4uw	2474	27	-	-	HYPH
cord-001835-0s7ok4uw	2474	28	off	off	RP
cord-001835-0s7ok4uw	2474	29	distance	distance	NN
cord-001835-0s7ok4uw	2474	30	4.5	4.5	CD
cord-001835-0s7ok4uw	2474	31	Å	å	NN
cord-001835-0s7ok4uw	2474	32	for	for	IN
cord-001835-0s7ok4uw	2474	33	each	each	DT
cord-001835-0s7ok4uw	2474	34	residue	residue	NN
cord-001835-0s7ok4uw	2474	35	pair	pair	NN
cord-001835-0s7ok4uw	2474	36	.	.	.
cord-001835-0s7ok4uw	2475	1	Twenty	twenty	CD
cord-001835-0s7ok4uw	2475	2	shortest	short	JJS
cord-001835-0s7ok4uw	2475	3	pathways	pathway	NNS
cord-001835-0s7ok4uw	2475	4	were	be	VBD
cord-001835-0s7ok4uw	2475	5	revealed	reveal	VBN
cord-001835-0s7ok4uw	2475	6	using	use	VBG
cord-001835-0s7ok4uw	2475	7	k	k	NN
cord-001835-0s7ok4uw	2475	8	-	-	HYPH
cord-001835-0s7ok4uw	2475	9	shortest	short	JJS
cord-001835-0s7ok4uw	2475	10	path	path	NN
cord-001835-0s7ok4uw	2475	11	algorithm	algorithm	NN
cord-001835-0s7ok4uw	2475	12	[	[	-LRB-
cord-001835-0s7ok4uw	2475	13	2	2	CD
cord-001835-0s7ok4uw	2475	14	]	]	-RRB-
cord-001835-0s7ok4uw	2475	15	on	on	IN
cord-001835-0s7ok4uw	2475	16	the	the	DT
cord-001835-0s7ok4uw	2475	17	coarse	coarse	RB
cord-001835-0s7ok4uw	2475	18	-	-	HYPH
cord-001835-0s7ok4uw	2475	19	grained	grained	JJ
cord-001835-0s7ok4uw	2475	20	network	network	NN
cord-001835-0s7ok4uw	2475	21	.	.	.
cord-001835-0s7ok4uw	2476	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2476	2	results	result	NNS
cord-001835-0s7ok4uw	2476	3	indicated	indicate	VBD
cord-001835-0s7ok4uw	2476	4	that	that	IN
cord-001835-0s7ok4uw	2476	5	distinct	distinct	JJ
cord-001835-0s7ok4uw	2476	6	signaling	signal	VBG
cord-001835-0s7ok4uw	2476	7	paths	path	NNS
cord-001835-0s7ok4uw	2476	8	progressed	progress	VBD
cord-001835-0s7ok4uw	2476	9	most	most	RBS
cord-001835-0s7ok4uw	2476	10	frequently	frequently	RB
cord-001835-0s7ok4uw	2476	11	on	on	IN
cord-001835-0s7ok4uw	2476	12	TM6	tm6	NN
cord-001835-0s7ok4uw	2476	13	but	but	CC
cord-001835-0s7ok4uw	2476	14	alternative	alternative	JJ
cord-001835-0s7ok4uw	2476	15	paths	path	NNS
cord-001835-0s7ok4uw	2476	16	were	be	VBD
cord-001835-0s7ok4uw	2476	17	also	also	RB
cord-001835-0s7ok4uw	2476	18	present	present	JJ
cord-001835-0s7ok4uw	2476	19	,	,	,
cord-001835-0s7ok4uw	2476	20	which	which	WDT
cord-001835-0s7ok4uw	2476	21	passed	pass	VBD
cord-001835-0s7ok4uw	2476	22	partially	partially	RB
cord-001835-0s7ok4uw	2476	23	through	through	IN
cord-001835-0s7ok4uw	2476	24	TM5	TM5	NNP
cord-001835-0s7ok4uw	2476	25	,	,	,
cord-001835-0s7ok4uw	2476	26	TM7	TM7	NNP
cord-001835-0s7ok4uw	2476	27	,	,	,
cord-001835-0s7ok4uw	2476	28	TM3	TM3	NNP
cord-001835-0s7ok4uw	2476	29	or	or	CC
cord-001835-0s7ok4uw	2476	30	TM2	TM2	NNP
cord-001835-0s7ok4uw	2476	31	depending	depend	VBG
cord-001835-0s7ok4uw	2476	32	on	on	IN
cord-001835-0s7ok4uw	2476	33	the	the	DT
cord-001835-0s7ok4uw	2476	34	conformation	conformation	NN
cord-001835-0s7ok4uw	2476	35	.	.	.
cord-001835-0s7ok4uw	2477	1	Among	among	IN
cord-001835-0s7ok4uw	2477	2	the	the	DT
cord-001835-0s7ok4uw	2477	3	critical	critical	JJ
cord-001835-0s7ok4uw	2477	4	residues	residue	NNS
cord-001835-0s7ok4uw	2477	5	that	that	WDT
cord-001835-0s7ok4uw	2477	6	transmitted	transmit	VBD
cord-001835-0s7ok4uw	2477	7	the	the	DT
cord-001835-0s7ok4uw	2477	8	signal	signal	NN
cord-001835-0s7ok4uw	2477	9	between	between	IN
cord-001835-0s7ok4uw	2477	10	distant	distant	JJ
cord-001835-0s7ok4uw	2477	11	sites	site	NNS
cord-001835-0s7ok4uw	2477	12	,	,	,
cord-001835-0s7ok4uw	2477	13	F282	F282	NNS
cord-001835-0s7ok4uw	2477	14	and	and	CC
cord-001835-0s7ok4uw	2477	15	N318	N318	NNPS
cord-001835-0s7ok4uw	2477	16	were	be	VBD
cord-001835-0s7ok4uw	2477	17	detected	detect	VBN
cord-001835-0s7ok4uw	2477	18	,	,	,
cord-001835-0s7ok4uw	2477	19	whose	whose	WP$
cord-001835-0s7ok4uw	2477	20	functional	functional	JJ
cord-001835-0s7ok4uw	2477	21	roles	role	NNS
cord-001835-0s7ok4uw	2477	22	were	be	VBD
cord-001835-0s7ok4uw	2477	23	reported	report	VBN
cord-001835-0s7ok4uw	2477	24	in	in	IN
cord-001835-0s7ok4uw	2477	25	previous	previous	JJ
cord-001835-0s7ok4uw	2477	26	experimental	experimental	JJ
cord-001835-0s7ok4uw	2477	27	studies	study	NNS
cord-001835-0s7ok4uw	2477	28	.	.	.
cord-001835-0s7ok4uw	2478	1	Pathway	pathway	NN
cord-001835-0s7ok4uw	2478	2	shifting	shifting	NN
cord-001835-0s7ok4uw	2478	3	was	be	VBD
cord-001835-0s7ok4uw	2478	4	observed	observe	VBN
cord-001835-0s7ok4uw	2478	5	depending	depend	VBG
cord-001835-0s7ok4uw	2478	6	on	on	IN
cord-001835-0s7ok4uw	2478	7	the	the	DT
cord-001835-0s7ok4uw	2478	8	open	open	JJ
cord-001835-0s7ok4uw	2478	9	-	-	HYPH
cord-001835-0s7ok4uw	2478	10	to	to	IN
cord-001835-0s7ok4uw	2478	11	-	-	HYPH
cord-001835-0s7ok4uw	2478	12	closed	close	VBN
cord-001835-0s7ok4uw	2478	13	transition	transition	NN
cord-001835-0s7ok4uw	2478	14	of	of	IN
cord-001835-0s7ok4uw	2478	15	ICL3	ICL3	NNP
cord-001835-0s7ok4uw	2478	16	during	during	IN
cord-001835-0s7ok4uw	2478	17	MD	MD	NNP
cord-001835-0s7ok4uw	2478	18	simulations	simulation	NNS
cord-001835-0s7ok4uw	2478	19	.	.	.
cord-001835-0s7ok4uw	2479	1	The	the	DT
cord-001835-0s7ok4uw	2479	2	sulfonylurea	sulfonylurea	NN
cord-001835-0s7ok4uw	2479	3	receptor	receptor	NN
cord-001835-0s7ok4uw	2479	4	1	1	CD
cord-001835-0s7ok4uw	2479	5	(	(	-LRB-
cord-001835-0s7ok4uw	2479	6	SUR1	SUR1	NNP
cord-001835-0s7ok4uw	2479	7	)	)	-RRB-
cord-001835-0s7ok4uw	2479	8	is	be	VBZ
cord-001835-0s7ok4uw	2479	9	an	an	DT
cord-001835-0s7ok4uw	2479	10	ATP	ATP	NNP
cord-001835-0s7ok4uw	2479	11	binding	binding	NN
cord-001835-0s7ok4uw	2479	12	cassette	cassette	NN
cord-001835-0s7ok4uw	2479	13	(	(	-LRB-
cord-001835-0s7ok4uw	2479	14	ABC	ABC	NNP
cord-001835-0s7ok4uw	2479	15	)	)	-RRB-
cord-001835-0s7ok4uw	2479	16	protein	protein	NN
cord-001835-0s7ok4uw	2479	17	that	that	WDT
cord-001835-0s7ok4uw	2479	18	forms	form	VBZ
cord-001835-0s7ok4uw	2479	19	the	the	DT
cord-001835-0s7ok4uw	2479	20	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	2479	21	subunit	subunit	NN
cord-001835-0s7ok4uw	2479	22	in	in	IN
cord-001835-0s7ok4uw	2479	23	KATP	KATP	NNP
cord-001835-0s7ok4uw	2479	24	channels	channel	NNS
cord-001835-0s7ok4uw	2479	25	found	find	VBN
cord-001835-0s7ok4uw	2479	26	in	in	IN
cord-001835-0s7ok4uw	2479	27	the	the	DT
cord-001835-0s7ok4uw	2479	28	pancreas	pancreas	NN
cord-001835-0s7ok4uw	2479	29	and	and	CC
cord-001835-0s7ok4uw	2479	30	the	the	DT
cord-001835-0s7ok4uw	2479	31	brain	brain	NN
cord-001835-0s7ok4uw	2479	32	.	.	.
cord-001835-0s7ok4uw	2480	1	MgATP	mgatp	IN
cord-001835-0s7ok4uw	2481	1	binding	bind	VBG
cord-001835-0s7ok4uw	2481	2	and	and	CC
cord-001835-0s7ok4uw	2481	3	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	2481	4	at	at	IN
cord-001835-0s7ok4uw	2481	5	the	the	DT
cord-001835-0s7ok4uw	2481	6	two	two	CD
cord-001835-0s7ok4uw	2481	7	cytosolic	cytosolic	JJ
cord-001835-0s7ok4uw	2481	8	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	2481	9	binding	bind	VBG
cord-001835-0s7ok4uw	2481	10	domains	domain	NNS
cord-001835-0s7ok4uw	2481	11	(	(	-LRB-
cord-001835-0s7ok4uw	2481	12	NBD1	NBD1	NNP
cord-001835-0s7ok4uw	2481	13	and	and	CC
cord-001835-0s7ok4uw	2481	14	NBD2	NBD2	NNP
cord-001835-0s7ok4uw	2481	15	)	)	-RRB-
cord-001835-0s7ok4uw	2481	16	in	in	IN
cord-001835-0s7ok4uw	2481	17	SUR1	SUR1	NNP
cord-001835-0s7ok4uw	2481	18	control	control	NN
cord-001835-0s7ok4uw	2481	19	gating	gating	NN
cord-001835-0s7ok4uw	2481	20	of	of	IN
cord-001835-0s7ok4uw	2481	21	the	the	DT
cord-001835-0s7ok4uw	2481	22	KATP	KATP	NNP
cord-001835-0s7ok4uw	2481	23	channel	channel	NN
cord-001835-0s7ok4uw	2481	24	pore	pore	NN
cord-001835-0s7ok4uw	2481	25	.	.	.
cord-001835-0s7ok4uw	2482	1	1,2	1,2	LS
cord-001835-0s7ok4uw	2483	1	Proper	proper	JJ
cord-001835-0s7ok4uw	2483	2	regulation	regulation	NN
cord-001835-0s7ok4uw	2483	3	of	of	IN
cord-001835-0s7ok4uw	2483	4	KATP	KATP	NNP
cord-001835-0s7ok4uw	2483	5	channel	channel	NN
cord-001835-0s7ok4uw	2483	6	gating	gating	NN
cord-001835-0s7ok4uw	2483	7	by	by	IN
cord-001835-0s7ok4uw	2483	8	SUR1	SUR1	NNP
cord-001835-0s7ok4uw	2483	9	is	be	VBZ
cord-001835-0s7ok4uw	2483	10	critical	critical	JJ
cord-001835-0s7ok4uw	2483	11	.	.	.
cord-001835-0s7ok4uw	2484	1	2	2	LS
cord-001835-0s7ok4uw	2485	1	Over	over	IN
cord-001835-0s7ok4uw	2485	2	100	100	CD
cord-001835-0s7ok4uw	2485	3	mutations	mutation	NNS
cord-001835-0s7ok4uw	2485	4	that	that	WDT
cord-001835-0s7ok4uw	2485	5	lead	lead	VBP
cord-001835-0s7ok4uw	2485	6	to	to	IN
cord-001835-0s7ok4uw	2485	7	diabetes	diabetes	NN
cord-001835-0s7ok4uw	2485	8	,	,	,
cord-001835-0s7ok4uw	2485	9	hyperinsulinism	hyperinsulinism	JJ
cord-001835-0s7ok4uw	2485	10	and	and	CC
cord-001835-0s7ok4uw	2485	11	developmental	developmental	JJ
cord-001835-0s7ok4uw	2485	12	delay	delay	NN
cord-001835-0s7ok4uw	2485	13	have	have	VBP
cord-001835-0s7ok4uw	2485	14	been	be	VBN
cord-001835-0s7ok4uw	2485	15	identified	identify	VBN
cord-001835-0s7ok4uw	2485	16	in	in	IN
cord-001835-0s7ok4uw	2485	17	different	different	JJ
cord-001835-0s7ok4uw	2485	18	domains	domain	NNS
cord-001835-0s7ok4uw	2485	19	of	of	IN
cord-001835-0s7ok4uw	2485	20	SUR1	SUR1	NNP
cord-001835-0s7ok4uw	2485	21	,	,	,
cord-001835-0s7ok4uw	2485	22	including	include	VBG
cord-001835-0s7ok4uw	2485	23	the	the	DT
cord-001835-0s7ok4uw	2485	24	NBDs	nbd	NNS
cord-001835-0s7ok4uw	2485	25	.	.	.
cord-001835-0s7ok4uw	2486	1	3	3	LS
cord-001835-0s7ok4uw	2487	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	2487	2	,	,	,
cord-001835-0s7ok4uw	2487	3	molecular	molecular	JJ
cord-001835-0s7ok4uw	2487	4	-	-	HYPH
cord-001835-0s7ok4uw	2487	5	level	level	NN
cord-001835-0s7ok4uw	2487	6	understanding	understanding	NN
cord-001835-0s7ok4uw	2487	7	of	of	IN
cord-001835-0s7ok4uw	2487	8	the	the	DT
cord-001835-0s7ok4uw	2487	9	structure	structure	NN
cord-001835-0s7ok4uw	2487	10	and	and	CC
cord-001835-0s7ok4uw	2487	11	function	function	NN
cord-001835-0s7ok4uw	2487	12	of	of	IN
cord-001835-0s7ok4uw	2487	13	the	the	DT
cord-001835-0s7ok4uw	2487	14	NBDs	nbd	NNS
cord-001835-0s7ok4uw	2487	15	is	be	VBZ
cord-001835-0s7ok4uw	2487	16	essential	essential	JJ
cord-001835-0s7ok4uw	2487	17	for	for	IN
cord-001835-0s7ok4uw	2487	18	designing	design	VBG
cord-001835-0s7ok4uw	2487	19	improved	improved	JJ
cord-001835-0s7ok4uw	2487	20	treatments	treatment	NNS
cord-001835-0s7ok4uw	2487	21	for	for	IN
cord-001835-0s7ok4uw	2487	22	SUR	sur	NN
cord-001835-0s7ok4uw	2487	23	-	-	HYPH
cord-001835-0s7ok4uw	2487	24	related	relate	VBN
cord-001835-0s7ok4uw	2487	25	diseases	disease	NNS
cord-001835-0s7ok4uw	2487	26	.	.	.
cord-001835-0s7ok4uw	2488	1	Here	here	RB
cord-001835-0s7ok4uw	2488	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2488	3	present	present	VBP
cord-001835-0s7ok4uw	2488	4	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	2488	5	and	and	CC
cord-001835-0s7ok4uw	2488	6	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	2488	7	studies	study	NNS
cord-001835-0s7ok4uw	2488	8	aimed	aim	VBN
cord-001835-0s7ok4uw	2488	9	at	at	IN
cord-001835-0s7ok4uw	2488	10	understanding	understand	VBG
cord-001835-0s7ok4uw	2488	11	the	the	DT
cord-001835-0s7ok4uw	2488	12	effect	effect	NN
cord-001835-0s7ok4uw	2488	13	of	of	IN
cord-001835-0s7ok4uw	2488	14	disease	disease	NN
cord-001835-0s7ok4uw	2488	15	-	-	HYPH
cord-001835-0s7ok4uw	2488	16	causing	cause	VBG
cord-001835-0s7ok4uw	2488	17	mutations	mutation	NNS
cord-001835-0s7ok4uw	2488	18	on	on	IN
cord-001835-0s7ok4uw	2488	19	the	the	DT
cord-001835-0s7ok4uw	2488	20	conformation	conformation	NN
cord-001835-0s7ok4uw	2488	21	and	and	CC
cord-001835-0s7ok4uw	2488	22	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	2488	23	binding	binding	NN
cord-001835-0s7ok4uw	2488	24	of	of	IN
cord-001835-0s7ok4uw	2488	25	SUR1	SUR1	NNP
cord-001835-0s7ok4uw	2488	26	NBD1	NBD1	NNP
cord-001835-0s7ok4uw	2488	27	.	.	.
cord-001835-0s7ok4uw	2489	1	Specifically	specifically	RB
cord-001835-0s7ok4uw	2489	2	,	,	,
cord-001835-0s7ok4uw	2489	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2489	4	are	be	VBP
cord-001835-0s7ok4uw	2489	5	investigating	investigate	VBG
cord-001835-0s7ok4uw	2489	6	SUR1	SUR1	NNP
cord-001835-0s7ok4uw	2489	7	NBD1	NBD1	NNP
cord-001835-0s7ok4uw	2489	8	mutations	mutation	NNS
cord-001835-0s7ok4uw	2489	9	that	that	WDT
cord-001835-0s7ok4uw	2489	10	cause	cause	VBP
cord-001835-0s7ok4uw	2489	11	neonatal	neonatal	JJ
cord-001835-0s7ok4uw	2489	12	diabetes	diabetes	NN
cord-001835-0s7ok4uw	2489	13	(	(	-LRB-
cord-001835-0s7ok4uw	2489	14	R826W	R826W	NNP
cord-001835-0s7ok4uw	2489	15	and	and	CC
cord-001835-0s7ok4uw	2489	16	H863	H863	NNP
cord-001835-0s7ok4uw	2489	17	T	T	NNP
cord-001835-0s7ok4uw	2489	18	)	)	-RRB-
cord-001835-0s7ok4uw	2489	19	or	or	CC
cord-001835-0s7ok4uw	2489	20	congenital	congenital	JJ
cord-001835-0s7ok4uw	2489	21	hyperinsulinism	hyperinsulinism	NN
cord-001835-0s7ok4uw	2489	22	(	(	-LRB-
cord-001835-0s7ok4uw	2489	23	C717	C717	NNP
cord-001835-0s7ok4uw	2489	24	D	D	NNP
cord-001835-0s7ok4uw	2489	25	,	,	,
cord-001835-0s7ok4uw	2489	26	G716V	G716V	NNP
cord-001835-0s7ok4uw	2489	27	,	,	,
cord-001835-0s7ok4uw	2489	28	R824	R824	NNP
cord-001835-0s7ok4uw	2489	29	G	g	NN
cord-001835-0s7ok4uw	2489	30	,	,	,
cord-001835-0s7ok4uw	2489	31	R837	r837	NN
cord-001835-0s7ok4uw	2489	32	D	D	NNP
cord-001835-0s7ok4uw	2489	33	and	and	CC
cord-001835-0s7ok4uw	2489	34	K890	K890	NNP
cord-001835-0s7ok4uw	2489	35	T	T	NNP
cord-001835-0s7ok4uw	2489	36	)	)	-RRB-
cord-001835-0s7ok4uw	2489	37	.	.	.
cord-001835-0s7ok4uw	2490	1	3	3	LS
cord-001835-0s7ok4uw	2491	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2491	2	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	2491	3	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	2491	4	resonance	resonance	NN
cord-001835-0s7ok4uw	2491	5	(	(	-LRB-
cord-001835-0s7ok4uw	2491	6	NMR	NMR	NNP
cord-001835-0s7ok4uw	2491	7	)	)	-RRB-
cord-001835-0s7ok4uw	2491	8	data	data	NN
cord-001835-0s7ok4uw	2491	9	shows	show	VBZ
cord-001835-0s7ok4uw	2491	10	that	that	IN
cord-001835-0s7ok4uw	2491	11	the	the	DT
cord-001835-0s7ok4uw	2491	12	hyperinsulinism	hyperinsulinism	NNP
cord-001835-0s7ok4uw	2491	13	mutation	mutation	NNP
cord-001835-0s7ok4uw	2491	14	K890	K890	NNP
cord-001835-0s7ok4uw	2491	15	T	T	NNP
cord-001835-0s7ok4uw	2491	16	causes	cause	VBZ
cord-001835-0s7ok4uw	2491	17	chemical	chemical	NN
cord-001835-0s7ok4uw	2491	18	shift	shift	NN
cord-001835-0s7ok4uw	2491	19	changes	change	NNS
cord-001835-0s7ok4uw	2491	20	throughout	throughout	IN
cord-001835-0s7ok4uw	2491	21	the	the	DT
cord-001835-0s7ok4uw	2491	22	spectrum	spectrum	NN
cord-001835-0s7ok4uw	2491	23	of	of	IN
cord-001835-0s7ok4uw	2491	24	NBD1	NBD1	NNP
cord-001835-0s7ok4uw	2491	25	,	,	,
cord-001835-0s7ok4uw	2491	26	implying	imply	VBG
cord-001835-0s7ok4uw	2491	27	overall	overall	JJ
cord-001835-0s7ok4uw	2491	28	changes	change	NNS
cord-001835-0s7ok4uw	2491	29	in	in	IN
cord-001835-0s7ok4uw	2491	30	protein	protein	NN
cord-001835-0s7ok4uw	2491	31	conformation	conformation	NN
cord-001835-0s7ok4uw	2491	32	that	that	WDT
cord-001835-0s7ok4uw	2491	33	may	may	MD
cord-001835-0s7ok4uw	2491	34	affect	affect	VB
cord-001835-0s7ok4uw	2491	35	MgATP	mgatp	IN
cord-001835-0s7ok4uw	2491	36	binding	bind	VBG
cord-001835-0s7ok4uw	2491	37	and	and	CC
cord-001835-0s7ok4uw	2491	38	inter	inter	JJ
cord-001835-0s7ok4uw	2491	39	-	-	NN
cord-001835-0s7ok4uw	2491	40	domain	domain	JJ
cord-001835-0s7ok4uw	2491	41	interactions	interaction	NNS
cord-001835-0s7ok4uw	2491	42	with	with	IN
cord-001835-0s7ok4uw	2491	43	other	other	JJ
cord-001835-0s7ok4uw	2491	44	domains	domain	NNS
cord-001835-0s7ok4uw	2491	45	in	in	IN
cord-001835-0s7ok4uw	2491	46	the	the	DT
cord-001835-0s7ok4uw	2491	47	SUR1	SUR1	NNP
cord-001835-0s7ok4uw	2491	48	protein	protein	NN
cord-001835-0s7ok4uw	2491	49	.	.	.
cord-001835-0s7ok4uw	2492	1	Size	size	NN
cord-001835-0s7ok4uw	2492	2	-	-	HYPH
cord-001835-0s7ok4uw	2492	3	exclusion	exclusion	NN
cord-001835-0s7ok4uw	2492	4	data	datum	NNS
cord-001835-0s7ok4uw	2492	5	show	show	VBP
cord-001835-0s7ok4uw	2492	6	that	that	IN
cord-001835-0s7ok4uw	2492	7	the	the	DT
cord-001835-0s7ok4uw	2492	8	other	other	JJ
cord-001835-0s7ok4uw	2492	9	hyperinsulinism	hyperinsulinism	NN
cord-001835-0s7ok4uw	2492	10	mutations	mutation	NNS
cord-001835-0s7ok4uw	2492	11	(	(	-LRB-
cord-001835-0s7ok4uw	2492	12	C717	C717	``
cord-001835-0s7ok4uw	2492	13	D	D	NNP
cord-001835-0s7ok4uw	2492	14	,	,	,
cord-001835-0s7ok4uw	2492	15	G716V	G716V	NNP
cord-001835-0s7ok4uw	2492	16	,	,	,
cord-001835-0s7ok4uw	2492	17	R824	R824	NNP
cord-001835-0s7ok4uw	2492	18	G	g	NN
cord-001835-0s7ok4uw	2492	19	,	,	,
cord-001835-0s7ok4uw	2492	20	R837	r837	NN
cord-001835-0s7ok4uw	2492	21	D	d	NN
cord-001835-0s7ok4uw	2492	22	)	)	-RRB-
cord-001835-0s7ok4uw	2492	23	produce	produce	VBP
cord-001835-0s7ok4uw	2492	24	mostly	mostly	RB
cord-001835-0s7ok4uw	2492	25	aggregated	aggregate	VBN
cord-001835-0s7ok4uw	2492	26	protein	protein	NN
cord-001835-0s7ok4uw	2492	27	,	,	,
cord-001835-0s7ok4uw	2492	28	likely	likely	JJ
cord-001835-0s7ok4uw	2492	29	as	as	IN
cord-001835-0s7ok4uw	2492	30	a	a	DT
cord-001835-0s7ok4uw	2492	31	result	result	NN
cord-001835-0s7ok4uw	2492	32	of	of	IN
cord-001835-0s7ok4uw	2492	33	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	2492	34	of	of	IN
cord-001835-0s7ok4uw	2492	35	NBD1	NBD1	NNP
cord-001835-0s7ok4uw	2492	36	.	.	.
cord-001835-0s7ok4uw	2493	1	Misfolding	Misfolding	NNP
cord-001835-0s7ok4uw	2493	2	of	of	IN
cord-001835-0s7ok4uw	2493	3	NBD1	NBD1	NNP
cord-001835-0s7ok4uw	2493	4	may	may	MD
cord-001835-0s7ok4uw	2493	5	be	be	VB
cord-001835-0s7ok4uw	2493	6	the	the	DT
cord-001835-0s7ok4uw	2493	7	underlying	underlying	JJ
cord-001835-0s7ok4uw	2493	8	cause	cause	NN
cord-001835-0s7ok4uw	2493	9	of	of	IN
cord-001835-0s7ok4uw	2493	10	reduced	reduce	VBN
cord-001835-0s7ok4uw	2493	11	KATP	KATP	NNP
cord-001835-0s7ok4uw	2493	12	trafficking	trafficking	NN
cord-001835-0s7ok4uw	2493	13	seen	see	VBN
cord-001835-0s7ok4uw	2493	14	with	with	IN
cord-001835-0s7ok4uw	2493	15	these	these	DT
cord-001835-0s7ok4uw	2493	16	mutations	mutation	NNS
cord-001835-0s7ok4uw	2493	17	and	and	CC
cord-001835-0s7ok4uw	2493	18	hence	hence	RB
cord-001835-0s7ok4uw	2493	19	decreased	decrease	VBD
cord-001835-0s7ok4uw	2493	20	KATP	KATP	NNP
cord-001835-0s7ok4uw	2493	21	channel	channel	NN
cord-001835-0s7ok4uw	2493	22	gating	gating	NN
cord-001835-0s7ok4uw	2493	23	observed	observe	VBN
cord-001835-0s7ok4uw	2493	24	in	in	IN
cord-001835-0s7ok4uw	2493	25	hyperinsulinism	hyperinsulinism	NNP
cord-001835-0s7ok4uw	2493	26	.	.	.
cord-001835-0s7ok4uw	2494	1	In	in	IN
cord-001835-0s7ok4uw	2494	2	contrast	contrast	NN
cord-001835-0s7ok4uw	2494	3	to	to	IN
cord-001835-0s7ok4uw	2494	4	the	the	DT
cord-001835-0s7ok4uw	2494	5	K890	K890	NNP
cord-001835-0s7ok4uw	2494	6	T	T	NNP
cord-001835-0s7ok4uw	2494	7	mutations	mutation	NNS
cord-001835-0s7ok4uw	2494	8	,	,	,
cord-001835-0s7ok4uw	2494	9	the	the	DT
cord-001835-0s7ok4uw	2494	10	congenital	congenital	JJ
cord-001835-0s7ok4uw	2494	11	diabetes	diabetes	NN
cord-001835-0s7ok4uw	2494	12	-	-	HYPH
cord-001835-0s7ok4uw	2494	13	causing	cause	VBG
cord-001835-0s7ok4uw	2494	14	mutations	mutation	NNS
cord-001835-0s7ok4uw	2494	15	(	(	-LRB-
cord-001835-0s7ok4uw	2494	16	R826W	R826W	NNP
cord-001835-0s7ok4uw	2494	17	and	and	CC
cord-001835-0s7ok4uw	2494	18	H863	H863	NNP
cord-001835-0s7ok4uw	2494	19	T	T	NNP
cord-001835-0s7ok4uw	2494	20	)	)	-RRB-
cord-001835-0s7ok4uw	2494	21	cause	cause	VB
cord-001835-0s7ok4uw	2494	22	few	few	JJ
cord-001835-0s7ok4uw	2494	23	NBD1	NBD1	NNP
cord-001835-0s7ok4uw	2494	24	NMR	NMR	NNP
cord-001835-0s7ok4uw	2494	25	spectral	spectral	JJ
cord-001835-0s7ok4uw	2494	26	changes	change	NNS
cord-001835-0s7ok4uw	2494	27	.	.	.
cord-001835-0s7ok4uw	2495	1	However	however	RB
cord-001835-0s7ok4uw	2495	2	,	,	,
cord-001835-0s7ok4uw	2495	3	the	the	DT
cord-001835-0s7ok4uw	2495	4	congenital	congenital	JJ
cord-001835-0s7ok4uw	2495	5	diabetes	diabetes	NN
cord-001835-0s7ok4uw	2495	6	mutation	mutation	NN
cord-001835-0s7ok4uw	2495	7	R826W	R826W	NNP
cord-001835-0s7ok4uw	2495	8	decreases	decrease	VBZ
cord-001835-0s7ok4uw	2495	9	the	the	DT
cord-001835-0s7ok4uw	2495	10	affinity	affinity	NN
cord-001835-0s7ok4uw	2495	11	of	of	IN
cord-001835-0s7ok4uw	2495	12	NBD1	NBD1	NNP
cord-001835-0s7ok4uw	2495	13	for	for	IN
cord-001835-0s7ok4uw	2495	14	MgATP	MgATP	NNP
cord-001835-0s7ok4uw	2495	15	,	,	,
cord-001835-0s7ok4uw	2495	16	which	which	WDT
cord-001835-0s7ok4uw	2495	17	is	be	VBZ
cord-001835-0s7ok4uw	2495	18	unexpected	unexpected	JJ
cord-001835-0s7ok4uw	2495	19	for	for	IN
cord-001835-0s7ok4uw	2495	20	congenital	congenital	JJ
cord-001835-0s7ok4uw	2495	21	diabetes	diabetes	NN
cord-001835-0s7ok4uw	2495	22	mutations	mutation	NNS
cord-001835-0s7ok4uw	2495	23	.	.	.
cord-001835-0s7ok4uw	2496	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2496	2	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2496	3	,	,	,
cord-001835-0s7ok4uw	2496	4	circular	circular	JJ
cord-001835-0s7ok4uw	2496	5	dichroism	dichroism	NN
cord-001835-0s7ok4uw	2496	6	and	and	CC
cord-001835-0s7ok4uw	2496	7	microscale	microscale	JJ
cord-001835-0s7ok4uw	2496	8	thermophoresis	thermophoresis	NNP
cord-001835-0s7ok4uw	2496	9	data	datum	NNS
cord-001835-0s7ok4uw	2496	10	corroborate	corroborate	VBP
cord-001835-0s7ok4uw	2496	11	the	the	DT
cord-001835-0s7ok4uw	2496	12	results	result	NNS
cord-001835-0s7ok4uw	2496	13	that	that	WDT
cord-001835-0s7ok4uw	2496	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	2496	15	have	have	VBP
cord-001835-0s7ok4uw	2496	16	obtained	obtain	VBN
cord-001835-0s7ok4uw	2496	17	by	by	IN
cord-001835-0s7ok4uw	2496	18	NMR	NMR	NNP
cord-001835-0s7ok4uw	2496	19	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2496	20	.	.	.
cord-001835-0s7ok4uw	2497	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2497	2	data	datum	NNS
cord-001835-0s7ok4uw	2497	3	provide	provide	VBP
cord-001835-0s7ok4uw	2497	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	2497	5	-	-	HYPH
cord-001835-0s7ok4uw	2497	6	level	level	NN
cord-001835-0s7ok4uw	2497	7	details	detail	NNS
cord-001835-0s7ok4uw	2497	8	on	on	IN
cord-001835-0s7ok4uw	2497	9	the	the	DT
cord-001835-0s7ok4uw	2497	10	effects	effect	NNS
cord-001835-0s7ok4uw	2497	11	of	of	IN
cord-001835-0s7ok4uw	2497	12	disease	disease	NN
cord-001835-0s7ok4uw	2497	13	causing	cause	VBG
cord-001835-0s7ok4uw	2497	14	mutations	mutation	NNS
cord-001835-0s7ok4uw	2497	15	in	in	IN
cord-001835-0s7ok4uw	2497	16	human	human	JJ
cord-001835-0s7ok4uw	2497	17	SUR1	SUR1	NNP
cord-001835-0s7ok4uw	2497	18	.	.	.
cord-001835-0s7ok4uw	2498	1	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	2498	2	Increased	increase	VBN
cord-001835-0s7ok4uw	2498	3	stability	stability	NN
cord-001835-0s7ok4uw	2498	4	:	:	:
cord-001835-0s7ok4uw	2499	1	RMSF	RMSF	NNP
cord-001835-0s7ok4uw	2499	2	of	of	IN
cord-001835-0s7ok4uw	2499	3	the	the	DT
cord-001835-0s7ok4uw	2499	4	CA	CA	NNP
cord-001835-0s7ok4uw	2499	5	atoms	atom	NNS
cord-001835-0s7ok4uw	2499	6	during	during	IN
cord-001835-0s7ok4uw	2499	7	the	the	DT
cord-001835-0s7ok4uw	2499	8	MD	MD	NNP
cord-001835-0s7ok4uw	2499	9	simulations	simulation	NNS
cord-001835-0s7ok4uw	2499	10	suggest	suggest	VBP
cord-001835-0s7ok4uw	2499	11	that	that	IN
cord-001835-0s7ok4uw	2499	12	glycosylation	glycosylation	NN
cord-001835-0s7ok4uw	2499	13	is	be	VBZ
cord-001835-0s7ok4uw	2499	14	associated	associate	VBN
cord-001835-0s7ok4uw	2499	15	with	with	IN
cord-001835-0s7ok4uw	2499	16	dampened	dampened	JJ
cord-001835-0s7ok4uw	2499	17	motions	motion	NNS
cord-001835-0s7ok4uw	2499	18	,	,	,
cord-001835-0s7ok4uw	2499	19	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2499	20	that	that	IN
cord-001835-0s7ok4uw	2499	21	the	the	DT
cord-001835-0s7ok4uw	2499	22	glycans	glycan	NNS
cord-001835-0s7ok4uw	2499	23	stabilize	stabilize	VBP
cord-001835-0s7ok4uw	2499	24	the	the	DT
cord-001835-0s7ok4uw	2499	25	structure	structure	NN
cord-001835-0s7ok4uw	2499	26	.	.	.
cord-001835-0s7ok4uw	2500	1	Subdomain	Subdomain	NNP
cord-001835-0s7ok4uw	2500	2	III	III	NNP
cord-001835-0s7ok4uw	2500	3	is	be	VBZ
cord-001835-0s7ok4uw	2500	4	the	the	DT
cord-001835-0s7ok4uw	2500	5	most	most	RBS
cord-001835-0s7ok4uw	2500	6	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	2500	7	while	while	IN
cord-001835-0s7ok4uw	2500	8	subdomain	subdomain	NN
cord-001835-0s7ok4uw	2500	9	I	-PRON-	PRP
cord-001835-0s7ok4uw	2500	10	is	be	VBZ
cord-001835-0s7ok4uw	2500	11	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	2500	12	largely	largely	RB
cord-001835-0s7ok4uw	2500	13	in	in	IN
cord-001835-0s7ok4uw	2500	14	the	the	DT
cord-001835-0s7ok4uw	2500	15	proximity	proximity	NN
cord-001835-0s7ok4uw	2500	16	of	of	IN
cord-001835-0s7ok4uw	2500	17	the	the	DT
cord-001835-0s7ok4uw	2500	18	ligand	ligand	NN
cord-001835-0s7ok4uw	2500	19	.	.	.
cord-001835-0s7ok4uw	2501	1	Both	both	DT
cord-001835-0s7ok4uw	2501	2	dimer	dimer	NN
cord-001835-0s7ok4uw	2501	3	interfaces	interface	NNS
cord-001835-0s7ok4uw	2501	4	including	include	VBG
cord-001835-0s7ok4uw	2501	5	the	the	DT
cord-001835-0s7ok4uw	2501	6	dimerization	dimerization	NN
cord-001835-0s7ok4uw	2501	7	arm	arm	NN
cord-001835-0s7ok4uw	2501	8	from	from	IN
cord-001835-0s7ok4uw	2501	9	domain	domain	NN
cord-001835-0s7ok4uw	2501	10	II	II	NNP
cord-001835-0s7ok4uw	2501	11	and	and	CC
cord-001835-0s7ok4uw	2501	12	the	the	DT
cord-001835-0s7ok4uw	2501	13	tip	tip	NN
cord-001835-0s7ok4uw	2501	14	of	of	IN
cord-001835-0s7ok4uw	2501	15	domain	domain	NN
cord-001835-0s7ok4uw	2501	16	IV	IV	NNP
cord-001835-0s7ok4uw	2501	17	fluctuate	fluctuate	VBP
cord-001835-0s7ok4uw	2501	18	less	less	JJR
cord-001835-0s7ok4uw	2501	19	upon	upon	IN
cord-001835-0s7ok4uw	2501	20	glycosylation	glycosylation	NN
cord-001835-0s7ok4uw	2501	21	.	.	.
cord-001835-0s7ok4uw	2502	1	Hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2502	2	bonding	bonding	NN
cord-001835-0s7ok4uw	2502	3	;	;	:
cord-001835-0s7ok4uw	2502	4	persistent	persistent	JJ
cord-001835-0s7ok4uw	2502	5	interactions	interaction	NNS
cord-001835-0s7ok4uw	2502	6	seen	see	VBN
cord-001835-0s7ok4uw	2502	7	for	for	IN
cord-001835-0s7ok4uw	2502	8	protein	protein	NN
cord-001835-0s7ok4uw	2502	9	-	-	HYPH
cord-001835-0s7ok4uw	2502	10	glycan	glycan	NN
cord-001835-0s7ok4uw	2502	11	:	:	:
cord-001835-0s7ok4uw	2502	12	In	in	IN
cord-001835-0s7ok4uw	2502	13	the	the	DT
cord-001835-0s7ok4uw	2502	14	disaccharide	disaccharide	NN
cord-001835-0s7ok4uw	2502	15	-	-	HYPH
cord-001835-0s7ok4uw	2502	16	containing	contain	VBG
cord-001835-0s7ok4uw	2502	17	system	system	NN
cord-001835-0s7ok4uw	2502	18	,	,	,
cord-001835-0s7ok4uw	2502	19	we	-PRON-	PRP
cord-001835-0s7ok4uw	2502	20	observed	observe	VBD
cord-001835-0s7ok4uw	2502	21	three	three	CD
cord-001835-0s7ok4uw	2502	22	highly	highly	RB
cord-001835-0s7ok4uw	2502	23	occupied	occupy	VBN
cord-001835-0s7ok4uw	2502	24	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2502	25	bonds	bond	NNS
cord-001835-0s7ok4uw	2502	26	between	between	IN
cord-001835-0s7ok4uw	2502	27	the	the	DT
cord-001835-0s7ok4uw	2502	28	glycans	glycan	NNS
cord-001835-0s7ok4uw	2502	29	and	and	CC
cord-001835-0s7ok4uw	2502	30	domain	domain	NN
cord-001835-0s7ok4uw	2502	31	III	III	NNP
cord-001835-0s7ok4uw	2502	32	and	and	CC
cord-001835-0s7ok4uw	2502	33	IV	IV	NNP
cord-001835-0s7ok4uw	2502	34	of	of	IN
cord-001835-0s7ok4uw	2502	35	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	2502	36	.	.	.
cord-001835-0s7ok4uw	2503	1	Hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2503	2	bonds	bond	NNS
cord-001835-0s7ok4uw	2503	3	of	of	IN
cord-001835-0s7ok4uw	2503	4	domain	domain	NN
cord-001835-0s7ok4uw	2503	5	III	iii	CD
cord-001835-0s7ok4uw	2503	6	involve	involve	VBP
cord-001835-0s7ok4uw	2503	7	the	the	DT
cord-001835-0s7ok4uw	2503	8	residue	residue	NN
cord-001835-0s7ok4uw	2503	9	Asp323	asp323	CD
cord-001835-0s7ok4uw	2503	10	in	in	IN
cord-001835-0s7ok4uw	2503	11	which	which	WDT
cord-001835-0s7ok4uw	2503	12	a	a	DT
cord-001835-0s7ok4uw	2503	13	sidechain	sidechain	NN
cord-001835-0s7ok4uw	2503	14	oxygen	oxygen	NN
cord-001835-0s7ok4uw	2503	15	interacts	interact	VBZ
cord-001835-0s7ok4uw	2503	16	with	with	IN
cord-001835-0s7ok4uw	2503	17	oxygen	oxygen	NN
cord-001835-0s7ok4uw	2503	18	atoms	atom	NNS
cord-001835-0s7ok4uw	2503	19	of	of	IN
cord-001835-0s7ok4uw	2503	20	the	the	DT
cord-001835-0s7ok4uw	2503	21	N	N	NNP
cord-001835-0s7ok4uw	2503	22	-	-	HYPH
cord-001835-0s7ok4uw	2503	23	acetylglucoseamine	acetylglucoseamine	NNP
cord-001835-0s7ok4uw	2503	24	linked	link	VBN
cord-001835-0s7ok4uw	2503	25	to	to	IN
cord-001835-0s7ok4uw	2503	26	Asn328	asn328	DT
cord-001835-0s7ok4uw	2503	27	.	.	.
cord-001835-0s7ok4uw	2504	1	In	in	IN
cord-001835-0s7ok4uw	2504	2	domain	domain	NN
cord-001835-0s7ok4uw	2504	3	IV	IV	NNP
cord-001835-0s7ok4uw	2504	4	a	a	DT
cord-001835-0s7ok4uw	2504	5	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2504	6	bond	bond	NN
cord-001835-0s7ok4uw	2504	7	is	be	VBZ
cord-001835-0s7ok4uw	2504	8	seen	see	VBN
cord-001835-0s7ok4uw	2504	9	between	between	IN
cord-001835-0s7ok4uw	2504	10	the	the	DT
cord-001835-0s7ok4uw	2504	11	Cys	Cys	NNP
cord-001835-0s7ok4uw	2504	12	515	515	CD
cord-001835-0s7ok4uw	2504	13	backbone	backbone	NN
cord-001835-0s7ok4uw	2504	14	amide	amide	NN
cord-001835-0s7ok4uw	2504	15	and	and	CC
cord-001835-0s7ok4uw	2504	16	the	the	DT
cord-001835-0s7ok4uw	2504	17	oxygen	oxygen	NN
cord-001835-0s7ok4uw	2504	18	atom	atom	NN
cord-001835-0s7ok4uw	2504	19	of	of	IN
cord-001835-0s7ok4uw	2504	20	N	N	NNP
cord-001835-0s7ok4uw	2504	21	-	-	HYPH
cord-001835-0s7ok4uw	2504	22	acetylglucosamine	acetylglucosamine	NNP
cord-001835-0s7ok4uw	2504	23	linked	link	VBN
cord-001835-0s7ok4uw	2504	24	to	to	IN
cord-001835-0s7ok4uw	2504	25	Asn	Asn	NNP
cord-001835-0s7ok4uw	2504	26	504	504	CD
cord-001835-0s7ok4uw	2504	27	.	.	.
cord-001835-0s7ok4uw	2505	1	In	in	IN
cord-001835-0s7ok4uw	2505	2	the	the	DT
cord-001835-0s7ok4uw	2505	3	oligosaccharide	oligosaccharide	NN
cord-001835-0s7ok4uw	2505	4	-	-	HYPH
cord-001835-0s7ok4uw	2505	5	containing	contain	VBG
cord-001835-0s7ok4uw	2505	6	system	system	NN
cord-001835-0s7ok4uw	2505	7	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2505	8	bonds	bond	NNS
cord-001835-0s7ok4uw	2505	9	observed	observe	VBN
cord-001835-0s7ok4uw	2505	10	between	between	IN
cord-001835-0s7ok4uw	2505	11	the	the	DT
cord-001835-0s7ok4uw	2505	12	glycan	glycan	NN
cord-001835-0s7ok4uw	2505	13	attached	attach	VBN
cord-001835-0s7ok4uw	2505	14	to	to	IN
cord-001835-0s7ok4uw	2505	15	Asn	Asn	NNP
cord-001835-0s7ok4uw	2505	16	172	172	CD
cord-001835-0s7ok4uw	2505	17	and	and	CC
cord-001835-0s7ok4uw	2505	18	domain	domain	NN
cord-001835-0s7ok4uw	2505	19	II	ii	CD
cord-001835-0s7ok4uw	2505	20	.	.	.
cord-001835-0s7ok4uw	2506	1	These	these	DT
cord-001835-0s7ok4uw	2506	2	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2506	3	bonds	bond	NNS
cord-001835-0s7ok4uw	2506	4	form	form	VBP
cord-001835-0s7ok4uw	2506	5	between	between	IN
cord-001835-0s7ok4uw	2506	6	the	the	DT
cord-001835-0s7ok4uw	2506	7	Gln193	gln193	CD
cord-001835-0s7ok4uw	2506	8	sidechain	sidechain	NNP
cord-001835-0s7ok4uw	2506	9	oxygen	oxygen	NN
cord-001835-0s7ok4uw	2506	10	atom	atom	NN
cord-001835-0s7ok4uw	2506	11	and	and	CC
cord-001835-0s7ok4uw	2506	12	Cys	Cys	NNP
cord-001835-0s7ok4uw	2506	13	191	191	CD
cord-001835-0s7ok4uw	2506	14	backbone	backbone	NN
cord-001835-0s7ok4uw	2506	15	oxygen	oxygen	NN
cord-001835-0s7ok4uw	2506	16	atom	atom	NN
cord-001835-0s7ok4uw	2506	17	and	and	CC
cord-001835-0s7ok4uw	2506	18	the	the	DT
cord-001835-0s7ok4uw	2506	19	Mannose	Mannose	NNP
cord-001835-0s7ok4uw	2506	20	linked	link	VBN
cord-001835-0s7ok4uw	2506	21	to	to	IN
cord-001835-0s7ok4uw	2506	22	Asn	Asn	NNP
cord-001835-0s7ok4uw	2506	23	172	172	CD
cord-001835-0s7ok4uw	2506	24	.	.	.
cord-001835-0s7ok4uw	2507	1	The	the	DT
cord-001835-0s7ok4uw	2507	2	reduction	reduction	NN
cord-001835-0s7ok4uw	2507	3	in	in	IN
cord-001835-0s7ok4uw	2507	4	the	the	DT
cord-001835-0s7ok4uw	2507	5	mobility	mobility	NN
cord-001835-0s7ok4uw	2507	6	of	of	IN
cord-001835-0s7ok4uw	2507	7	these	these	DT
cord-001835-0s7ok4uw	2507	8	amino	amino	NN
cord-001835-0s7ok4uw	2507	9	acids	acid	NNS
cord-001835-0s7ok4uw	2507	10	suggests	suggest	VBZ
cord-001835-0s7ok4uw	2507	11	that	that	IN
cord-001835-0s7ok4uw	2507	12	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2507	13	bonds	bond	NNS
cord-001835-0s7ok4uw	2507	14	impart	impart	VBP
cord-001835-0s7ok4uw	2507	15	stability	stability	NN
cord-001835-0s7ok4uw	2507	16	to	to	IN
cord-001835-0s7ok4uw	2507	17	both	both	CC
cord-001835-0s7ok4uw	2507	18	the	the	DT
cord-001835-0s7ok4uw	2507	19	sugars	sugar	NNS
cord-001835-0s7ok4uw	2507	20	and	and	CC
cord-001835-0s7ok4uw	2507	21	to	to	IN
cord-001835-0s7ok4uw	2507	22	the	the	DT
cord-001835-0s7ok4uw	2507	23	interacting	interact	VBG
cord-001835-0s7ok4uw	2507	24	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	2507	25	.	.	.
cord-001835-0s7ok4uw	2508	1	Insects	insect	NNS
cord-001835-0s7ok4uw	2508	2	possess	possess	VBP
cord-001835-0s7ok4uw	2508	3	a	a	DT
cord-001835-0s7ok4uw	2508	4	complement	complement	NN
cord-001835-0s7ok4uw	2508	5	-	-	HYPH
cord-001835-0s7ok4uw	2508	6	like	like	JJ
cord-001835-0s7ok4uw	2508	7	immune	immune	JJ
cord-001835-0s7ok4uw	2508	8	response	response	NN
cord-001835-0s7ok4uw	2508	9	utilizing	utilize	VBG
cord-001835-0s7ok4uw	2508	10	thioester	thioester	NN
cord-001835-0s7ok4uw	2508	11	-	-	HYPH
cord-001835-0s7ok4uw	2508	12	containing	contain	VBG
cord-001835-0s7ok4uw	2508	13	proteins	protein	NNS
cord-001835-0s7ok4uw	2508	14	,	,	,
cord-001835-0s7ok4uw	2508	15	or	or	CC
cord-001835-0s7ok4uw	2508	16	TEPs	tep	NNS
cord-001835-0s7ok4uw	2508	17	.	.	.
cord-001835-0s7ok4uw	2509	1	The	the	DT
cord-001835-0s7ok4uw	2509	2	only	only	JJ
cord-001835-0s7ok4uw	2509	3	arthropod	arthropod	NN
cord-001835-0s7ok4uw	2509	4	TEP	TEP	NNP
cord-001835-0s7ok4uw	2509	5	of	of	IN
cord-001835-0s7ok4uw	2509	6	known	know	VBN
cord-001835-0s7ok4uw	2509	7	structure	structure	NN
cord-001835-0s7ok4uw	2509	8	is	be	VBZ
cord-001835-0s7ok4uw	2509	9	Anopheles	Anopheles	NNP
cord-001835-0s7ok4uw	2509	10	gambiae	gambiae	NN
cord-001835-0s7ok4uw	2509	11	TEP1	TEP1	NNP
cord-001835-0s7ok4uw	2509	12	,	,	,
cord-001835-0s7ok4uw	2509	13	which	which	WDT
cord-001835-0s7ok4uw	2509	14	is	be	VBZ
cord-001835-0s7ok4uw	2509	15	a	a	DT
cord-001835-0s7ok4uw	2509	16	key	key	JJ
cord-001835-0s7ok4uw	2509	17	component	component	NN
cord-001835-0s7ok4uw	2509	18	in	in	IN
cord-001835-0s7ok4uw	2509	19	the	the	DT
cord-001835-0s7ok4uw	2509	20	natural	natural	JJ
cord-001835-0s7ok4uw	2509	21	immunity	immunity	NN
cord-001835-0s7ok4uw	2509	22	of	of	IN
cord-001835-0s7ok4uw	2509	23	this	this	DT
cord-001835-0s7ok4uw	2509	24	mosquito	mosquito	NN
cord-001835-0s7ok4uw	2509	25	to	to	IN
cord-001835-0s7ok4uw	2509	26	malaria	malaria	NN
cord-001835-0s7ok4uw	2509	27	parasites	parasite	NNS
cord-001835-0s7ok4uw	2509	28	(	(	-LRB-
cord-001835-0s7ok4uw	2509	29	genus	genus	NNP
cord-001835-0s7ok4uw	2509	30	Plasmodium	Plasmodium	NNP
cord-001835-0s7ok4uw	2509	31	)	)	-RRB-
cord-001835-0s7ok4uw	2509	32	.	.	.
cord-001835-0s7ok4uw	2510	1	Unlike	unlike	IN
cord-001835-0s7ok4uw	2510	2	vertebrate	vertebrate	JJ
cord-001835-0s7ok4uw	2510	3	complement	complement	NN
cord-001835-0s7ok4uw	2510	4	factors	factor	NNS
cord-001835-0s7ok4uw	2510	5	,	,	,
cord-001835-0s7ok4uw	2510	6	AgTEP1	agtep1	NN
cord-001835-0s7ok4uw	2510	7	does	do	VBZ
cord-001835-0s7ok4uw	2510	8	not	not	RB
cord-001835-0s7ok4uw	2510	9	contain	contain	VB
cord-001835-0s7ok4uw	2510	10	an	an	DT
cord-001835-0s7ok4uw	2510	11	anaphylatoxin	anaphylatoxin	NN
cord-001835-0s7ok4uw	2510	12	domain	domain	NN
cord-001835-0s7ok4uw	2510	13	which	which	WDT
cord-001835-0s7ok4uw	2510	14	acts	act	VBZ
cord-001835-0s7ok4uw	2510	15	to	to	TO
cord-001835-0s7ok4uw	2510	16	regulate	regulate	VB
cord-001835-0s7ok4uw	2510	17	a	a	DT
cord-001835-0s7ok4uw	2510	18	massive	massive	JJ
cord-001835-0s7ok4uw	2510	19	conformational	conformational	JJ
cord-001835-0s7ok4uw	2510	20	change	change	NN
cord-001835-0s7ok4uw	2510	21	accompanying	accompany	VBG
cord-001835-0s7ok4uw	2510	22	activation	activation	NN
cord-001835-0s7ok4uw	2510	23	of	of	IN
cord-001835-0s7ok4uw	2510	24	the	the	DT
cord-001835-0s7ok4uw	2510	25	protein	protein	NN
cord-001835-0s7ok4uw	2510	26	.	.	.
cord-001835-0s7ok4uw	2511	1	The	the	DT
cord-001835-0s7ok4uw	2511	2	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2511	3	of	of	IN
cord-001835-0s7ok4uw	2511	4	AgTEP1	agtep1	NN
cord-001835-0s7ok4uw	2511	5	must	must	MD
cord-001835-0s7ok4uw	2511	6	therefore	therefore	RB
cord-001835-0s7ok4uw	2511	7	involve	involve	VB
cord-001835-0s7ok4uw	2511	8	an	an	DT
cord-001835-0s7ok4uw	2511	9	alternative	alternative	JJ
cord-001835-0s7ok4uw	2511	10	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2511	11	for	for	IN
cord-001835-0s7ok4uw	2511	12	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2511	13	regulation	regulation	NN
cord-001835-0s7ok4uw	2511	14	of	of	IN
cord-001835-0s7ok4uw	2511	15	thioester	thioester	NN
cord-001835-0s7ok4uw	2511	16	activation	activation	NN
cord-001835-0s7ok4uw	2511	17	.	.	.
cord-001835-0s7ok4uw	2512	1	In	in	IN
cord-001835-0s7ok4uw	2512	2	place	place	NN
cord-001835-0s7ok4uw	2512	3	of	of	IN
cord-001835-0s7ok4uw	2512	4	a	a	DT
cord-001835-0s7ok4uw	2512	5	small	small	JJ
cord-001835-0s7ok4uw	2512	6	internal	internal	JJ
cord-001835-0s7ok4uw	2512	7	domain	domain	NN
cord-001835-0s7ok4uw	2512	8	,	,	,
cord-001835-0s7ok4uw	2512	9	a	a	DT
cord-001835-0s7ok4uw	2512	10	large	large	JJ
cord-001835-0s7ok4uw	2512	11	,	,	,
cord-001835-0s7ok4uw	2512	12	heterodimeric	heterodimeric	JJ
cord-001835-0s7ok4uw	2512	13	complex	complex	NN
cord-001835-0s7ok4uw	2512	14	of	of	IN
cord-001835-0s7ok4uw	2512	15	two	two	CD
cord-001835-0s7ok4uw	2512	16	leucine	leucine	NN
cord-001835-0s7ok4uw	2512	17	-	-	HYPH
cord-001835-0s7ok4uw	2512	18	rich	rich	JJ
cord-001835-0s7ok4uw	2512	19	repeat	repeat	NN
cord-001835-0s7ok4uw	2512	20	(	(	-LRB-
cord-001835-0s7ok4uw	2512	21	LRR	LRR	NNP
cord-001835-0s7ok4uw	2512	22	)	)	-RRB-
cord-001835-0s7ok4uw	2512	23	proteins	protein	NNS
cord-001835-0s7ok4uw	2512	24	,	,	,
cord-001835-0s7ok4uw	2512	25	LRIM1	lrim1	VB
cord-001835-0s7ok4uw	2512	26	and	and	CC
cord-001835-0s7ok4uw	2512	27	APL1C	APL1C	NNP
cord-001835-0s7ok4uw	2512	28	,	,	,
cord-001835-0s7ok4uw	2512	29	have	have	VBP
cord-001835-0s7ok4uw	2512	30	been	be	VBN
cord-001835-0s7ok4uw	2512	31	shown	show	VBN
cord-001835-0s7ok4uw	2512	32	to	to	TO
cord-001835-0s7ok4uw	2512	33	specifically	specifically	RB
cord-001835-0s7ok4uw	2512	34	bind	bind	VB
cord-001835-0s7ok4uw	2512	35	and	and	CC
cord-001835-0s7ok4uw	2512	36	stabilize	stabilize	VB
cord-001835-0s7ok4uw	2512	37	the	the	DT
cord-001835-0s7ok4uw	2512	38	active	active	JJ
cord-001835-0s7ok4uw	2512	39	conformation	conformation	NN
cord-001835-0s7ok4uw	2512	40	of	of	IN
cord-001835-0s7ok4uw	2512	41	AgTEP1	agtep1	NN
cord-001835-0s7ok4uw	2512	42	.	.	.
cord-001835-0s7ok4uw	2513	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	2513	2	will	will	MD
cord-001835-0s7ok4uw	2513	3	present	present	VB
cord-001835-0s7ok4uw	2513	4	my	-PRON-	PRP$
cord-001835-0s7ok4uw	2513	5	group	group	NN
cord-001835-0s7ok4uw	2513	6	's	's	POS
cord-001835-0s7ok4uw	2513	7	most	most	RBS
cord-001835-0s7ok4uw	2513	8	recent	recent	JJ
cord-001835-0s7ok4uw	2513	9	work	work	NN
cord-001835-0s7ok4uw	2513	10	in	in	IN
cord-001835-0s7ok4uw	2513	11	this	this	DT
cord-001835-0s7ok4uw	2513	12	area	area	NN
cord-001835-0s7ok4uw	2513	13	.	.	.
cord-001835-0s7ok4uw	2514	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2514	2	have	have	VBP
cord-001835-0s7ok4uw	2514	3	shown	show	VBN
cord-001835-0s7ok4uw	2514	4	that	that	IN
cord-001835-0s7ok4uw	2514	5	different	different	JJ
cord-001835-0s7ok4uw	2514	6	alleles	allele	NNS
cord-001835-0s7ok4uw	2514	7	of	of	IN
cord-001835-0s7ok4uw	2514	8	TEP1	TEP1	NNP
cord-001835-0s7ok4uw	2514	9	,	,	,
cord-001835-0s7ok4uw	2514	10	which	which	WDT
cord-001835-0s7ok4uw	2514	11	are	be	VBP
cord-001835-0s7ok4uw	2514	12	known	know	VBN
cord-001835-0s7ok4uw	2514	13	to	to	TO
cord-001835-0s7ok4uw	2514	14	influence	influence	VB
cord-001835-0s7ok4uw	2514	15	the	the	DT
cord-001835-0s7ok4uw	2514	16	vectoral	vectoral	JJ
cord-001835-0s7ok4uw	2514	17	capacity	capacity	NN
cord-001835-0s7ok4uw	2514	18	of	of	IN
cord-001835-0s7ok4uw	2514	19	wild	wild	JJ
cord-001835-0s7ok4uw	2514	20	mosquitoes	mosquito	NNS
cord-001835-0s7ok4uw	2514	21	,	,	,
cord-001835-0s7ok4uw	2514	22	differ	differ	VBP
cord-001835-0s7ok4uw	2514	23	significantly	significantly	RB
cord-001835-0s7ok4uw	2514	24	in	in	IN
cord-001835-0s7ok4uw	2514	25	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2514	26	susceptibility	susceptibility	NN
cord-001835-0s7ok4uw	2514	27	to	to	IN
cord-001835-0s7ok4uw	2514	28	thioester	thioester	NN
cord-001835-0s7ok4uw	2514	29	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	2514	30	.	.	.
cord-001835-0s7ok4uw	2515	1	Allelic	allelic	JJ
cord-001835-0s7ok4uw	2515	2	variation	variation	NN
cord-001835-0s7ok4uw	2515	3	is	be	VBZ
cord-001835-0s7ok4uw	2515	4	centered	center	VBN
cord-001835-0s7ok4uw	2515	5	on	on	IN
cord-001835-0s7ok4uw	2515	6	residues	residue	NNS
cord-001835-0s7ok4uw	2515	7	at	at	IN
cord-001835-0s7ok4uw	2515	8	the	the	DT
cord-001835-0s7ok4uw	2515	9	protein	protein	NN
cord-001835-0s7ok4uw	2515	10	-	-	HYPH
cord-001835-0s7ok4uw	2515	11	protein	protein	NN
cord-001835-0s7ok4uw	2515	12	interface	interface	NN
cord-001835-0s7ok4uw	2515	13	within	within	IN
cord-001835-0s7ok4uw	2515	14	TEP1	TEP1	NNP
cord-001835-0s7ok4uw	2515	15	containing	contain	VBG
cord-001835-0s7ok4uw	2515	16	the	the	DT
cord-001835-0s7ok4uw	2515	17	thioester	thioester	NNP
cord-001835-0s7ok4uw	2515	18	bond	bond	NN
cord-001835-0s7ok4uw	2515	19	.	.	.
cord-001835-0s7ok4uw	2516	1	The	the	DT
cord-001835-0s7ok4uw	2516	2	LRIM1	lrim1	XX
cord-001835-0s7ok4uw	2516	3	/	/	SYM
cord-001835-0s7ok4uw	2516	4	APL1C	apl1c	NN
cord-001835-0s7ok4uw	2516	5	heterodimer	heterodimer	NN
cord-001835-0s7ok4uw	2516	6	is	be	VBZ
cord-001835-0s7ok4uw	2516	7	shown	show	VBN
cord-001835-0s7ok4uw	2516	8	to	to	TO
cord-001835-0s7ok4uw	2516	9	form	form	VB
cord-001835-0s7ok4uw	2516	10	an	an	DT
cord-001835-0s7ok4uw	2516	11	extended	extended	JJ
cord-001835-0s7ok4uw	2516	12	and	and	CC
cord-001835-0s7ok4uw	2516	13	flexible	flexible	JJ
cord-001835-0s7ok4uw	2516	14	ensemble	ensemble	NN
cord-001835-0s7ok4uw	2516	15	in	in	IN
cord-001835-0s7ok4uw	2516	16	solution	solution	NN
cord-001835-0s7ok4uw	2516	17	.	.	.
cord-001835-0s7ok4uw	2517	1	Two	two	CD
cord-001835-0s7ok4uw	2517	2	closely	closely	RB
cord-001835-0s7ok4uw	2517	3	-	-	HYPH
cord-001835-0s7ok4uw	2517	4	related	relate	VBN
cord-001835-0s7ok4uw	2517	5	genes	gene	NNS
cord-001835-0s7ok4uw	2517	6	to	to	IN
cord-001835-0s7ok4uw	2517	7	APL1C	apl1c	ADD
cord-001835-0s7ok4uw	2517	8	,	,	,
cord-001835-0s7ok4uw	2517	9	APL1A	apl1a	NN
cord-001835-0s7ok4uw	2517	10	and	and	CC
cord-001835-0s7ok4uw	2517	11	APL1B	apl1b	NN
cord-001835-0s7ok4uw	2517	12	,	,	,
cord-001835-0s7ok4uw	2517	13	can	can	MD
cord-001835-0s7ok4uw	2517	14	also	also	RB
cord-001835-0s7ok4uw	2517	15	form	form	VB
cord-001835-0s7ok4uw	2517	16	a	a	DT
cord-001835-0s7ok4uw	2517	17	complex	complex	NN
cord-001835-0s7ok4uw	2517	18	with	with	IN
cord-001835-0s7ok4uw	2517	19	LRIM1	lrim1	ADD
cord-001835-0s7ok4uw	2517	20	,	,	,
cord-001835-0s7ok4uw	2517	21	and	and	CC
cord-001835-0s7ok4uw	2517	22	APL1B	apl1b	NN
cord-001835-0s7ok4uw	2517	23	LRR	LRR	NNP
cord-001835-0s7ok4uw	2517	24	domain	domain	NN
cord-001835-0s7ok4uw	2517	25	can	can	MD
cord-001835-0s7ok4uw	2517	26	form	form	VB
cord-001835-0s7ok4uw	2517	27	a	a	DT
cord-001835-0s7ok4uw	2517	28	homodimer	homodimer	NN
cord-001835-0s7ok4uw	2517	29	.	.	.
cord-001835-0s7ok4uw	2518	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2518	2	propose	propose	VBP
cord-001835-0s7ok4uw	2518	3	that	that	IN
cord-001835-0s7ok4uw	2518	4	a	a	DT
cord-001835-0s7ok4uw	2518	5	flexible	flexible	JJ
cord-001835-0s7ok4uw	2518	6	and	and	CC
cord-001835-0s7ok4uw	2518	7	heterogeneous	heterogeneous	JJ
cord-001835-0s7ok4uw	2518	8	group	group	NN
cord-001835-0s7ok4uw	2518	9	ensemble	ensemble	NN
cord-001835-0s7ok4uw	2518	10	of	of	IN
cord-001835-0s7ok4uw	2518	11	LRIM1	LRIM1	NNP
cord-001835-0s7ok4uw	2518	12	/	/	SYM
cord-001835-0s7ok4uw	2518	13	APL1	APL1	NNP
cord-001835-0s7ok4uw	2518	14	dimers	dimer	NNS
cord-001835-0s7ok4uw	2518	15	interact	interact	VBP
cord-001835-0s7ok4uw	2518	16	with	with	IN
cord-001835-0s7ok4uw	2518	17	the	the	DT
cord-001835-0s7ok4uw	2518	18	active	active	JJ
cord-001835-0s7ok4uw	2518	19	conformation	conformation	NN
cord-001835-0s7ok4uw	2518	20	of	of	IN
cord-001835-0s7ok4uw	2518	21	TEP1	TEP1	NNP
cord-001835-0s7ok4uw	2518	22	,	,	,
cord-001835-0s7ok4uw	2518	23	thereby	thereby	RB
cord-001835-0s7ok4uw	2518	24	producing	produce	VBG
cord-001835-0s7ok4uw	2518	25	an	an	DT
cord-001835-0s7ok4uw	2518	26	array	array	NN
cord-001835-0s7ok4uw	2518	27	of	of	IN
cord-001835-0s7ok4uw	2518	28	immune	immune	JJ
cord-001835-0s7ok4uw	2518	29	complexes	complex	NNS
cord-001835-0s7ok4uw	2518	30	to	to	TO
cord-001835-0s7ok4uw	2518	31	protect	protect	VB
cord-001835-0s7ok4uw	2518	32	mosquitoes	mosquito	NNS
cord-001835-0s7ok4uw	2518	33	from	from	IN
cord-001835-0s7ok4uw	2518	34	a	a	DT
cord-001835-0s7ok4uw	2518	35	diverse	diverse	JJ
cord-001835-0s7ok4uw	2518	36	set	set	NN
cord-001835-0s7ok4uw	2518	37	of	of	IN
cord-001835-0s7ok4uw	2518	38	pathogens	pathogen	NNS
cord-001835-0s7ok4uw	2518	39	.	.	.
cord-001835-0s7ok4uw	2519	1	Human	human	JJ
cord-001835-0s7ok4uw	2519	2	Flap	flap	NN
cord-001835-0s7ok4uw	2519	3	Endonuclease-1	Endonuclease-1	NNP
cord-001835-0s7ok4uw	2519	4	(	(	-LRB-
cord-001835-0s7ok4uw	2519	5	hFEN1	hfen1	NN
cord-001835-0s7ok4uw	2519	6	)	)	-RRB-
cord-001835-0s7ok4uw	2519	7	is	be	VBZ
cord-001835-0s7ok4uw	2519	8	an	an	DT
cord-001835-0s7ok4uw	2519	9	essential	essential	JJ
cord-001835-0s7ok4uw	2519	10	metallo	metallo	NN
cord-001835-0s7ok4uw	2519	11	-	-	HYPH
cord-001835-0s7ok4uw	2519	12	nuclease	nuclease	NN
cord-001835-0s7ok4uw	2519	13	involved	involve	VBN
cord-001835-0s7ok4uw	2519	14	in	in	IN
cord-001835-0s7ok4uw	2519	15	Okazaki	Okazaki	NNP
cord-001835-0s7ok4uw	2519	16	Fragment	Fragment	NNP
cord-001835-0s7ok4uw	2519	17	maturation	maturation	NN
cord-001835-0s7ok4uw	2519	18	and	and	CC
cord-001835-0s7ok4uw	2519	19	long	long	JJ
cord-001835-0s7ok4uw	2519	20	-	-	HYPH
cord-001835-0s7ok4uw	2519	21	patch	patch	NN
cord-001835-0s7ok4uw	2519	22	base	base	NN
cord-001835-0s7ok4uw	2519	23	excision	excision	NN
cord-001835-0s7ok4uw	2519	24	repair	repair	NN
cord-001835-0s7ok4uw	2519	25	.	.	.
cord-001835-0s7ok4uw	2520	1	During	during	IN
cord-001835-0s7ok4uw	2520	2	these	these	DT
cord-001835-0s7ok4uw	2520	3	processes	process	NNS
cord-001835-0s7ok4uw	2520	4	,	,	,
cord-001835-0s7ok4uw	2520	5	bifurcated	bifurcated	JJ
cord-001835-0s7ok4uw	2520	6	nucleic	nucleic	JJ
cord-001835-0s7ok4uw	2520	7	acid	acid	NN
cord-001835-0s7ok4uw	2520	8	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	2520	9	with	with	IN
cord-001835-0s7ok4uw	2520	10	ssDNA	ssdna	JJ
cord-001835-0s7ok4uw	2520	11	5'-flaps	5'-flaps	CD
cord-001835-0s7ok4uw	2520	12	are	be	VBP
cord-001835-0s7ok4uw	2520	13	generated	generate	VBN
cord-001835-0s7ok4uw	2520	14	by	by	IN
cord-001835-0s7ok4uw	2520	15	polymerase	polymerase	NN
cord-001835-0s7ok4uw	2520	16	strand	strand	NN
cord-001835-0s7ok4uw	2520	17	displacement	displacement	NN
cord-001835-0s7ok4uw	2520	18	synthesis	synthesis	NN
cord-001835-0s7ok4uw	2520	19	and	and	CC
cord-001835-0s7ok4uw	2520	20	then	then	RB
cord-001835-0s7ok4uw	2520	21	cleaved	cleave	VBD
cord-001835-0s7ok4uw	2520	22	one	one	CD
cord-001835-0s7ok4uw	2520	23	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	2520	24	into	into	IN
cord-001835-0s7ok4uw	2520	25	the	the	DT
cord-001835-0s7ok4uw	2520	26	downstream	downstream	JJ
cord-001835-0s7ok4uw	2520	27	duplex	duplex	NN
cord-001835-0s7ok4uw	2520	28	by	by	IN
cord-001835-0s7ok4uw	2520	29	FEN1	FEN1	NNP
cord-001835-0s7ok4uw	2520	30	to	to	TO
cord-001835-0s7ok4uw	2520	31	create	create	VB
cord-001835-0s7ok4uw	2520	32	a	a	DT
cord-001835-0s7ok4uw	2520	33	nicked	nick	VBN
cord-001835-0s7ok4uw	2520	34	-	-	HYPH
cord-001835-0s7ok4uw	2520	35	DNA	dna	NN
cord-001835-0s7ok4uw	2520	36	that	that	WDT
cord-001835-0s7ok4uw	2520	37	is	be	VBZ
cord-001835-0s7ok4uw	2520	38	a	a	DT
cord-001835-0s7ok4uw	2520	39	suitable	suitable	JJ
cord-001835-0s7ok4uw	2520	40	substrate	substrate	NN
cord-001835-0s7ok4uw	2520	41	for	for	IN
cord-001835-0s7ok4uw	2520	42	ligase	ligase	NN
cord-001835-0s7ok4uw	2520	43	.	.	.
cord-001835-0s7ok4uw	2521	1	Until	until	IN
cord-001835-0s7ok4uw	2521	2	recently	recently	RB
cord-001835-0s7ok4uw	2521	3	,	,	,
cord-001835-0s7ok4uw	2521	4	how	how	WRB
cord-001835-0s7ok4uw	2521	5	hFEN1	hfen1	NN
cord-001835-0s7ok4uw	2521	6	achieves	achieve	VBZ
cord-001835-0s7ok4uw	2521	7	tremendous	tremendous	JJ
cord-001835-0s7ok4uw	2521	8	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2521	9	power	power	NN
cord-001835-0s7ok4uw	2521	10	(	(	-LRB-
cord-001835-0s7ok4uw	2521	11	rate	rate	NN
cord-001835-0s7ok4uw	2521	12	enhancements	enhancement	NNS
cord-001835-0s7ok4uw	2521	13	>	>	NFP
cord-001835-0s7ok4uw	2521	14	10exp17	10exp17	CD
cord-001835-0s7ok4uw	2521	15	)	)	-RRB-
cord-001835-0s7ok4uw	2521	16	and	and	CC
cord-001835-0s7ok4uw	2521	17	exquisite	exquisite	JJ
cord-001835-0s7ok4uw	2521	18	selectivity	selectivity	NN
cord-001835-0s7ok4uw	2521	19	for	for	IN
cord-001835-0s7ok4uw	2521	20	the	the	DT
cord-001835-0s7ok4uw	2521	21	scissile	scissile	NN
cord-001835-0s7ok4uw	2521	22	phosphate	phosphate	NN
cord-001835-0s7ok4uw	2521	23	had	have	VBD
cord-001835-0s7ok4uw	2521	24	been	be	VBN
cord-001835-0s7ok4uw	2521	25	understood	understand	VBN
cord-001835-0s7ok4uw	2521	26	poorly	poorly	RB
cord-001835-0s7ok4uw	2521	27	(	(	-LRB-
cord-001835-0s7ok4uw	2521	28	1	1	CD
cord-001835-0s7ok4uw	2521	29	)	)	-RRB-
cord-001835-0s7ok4uw	2521	30	.	.	.
cord-001835-0s7ok4uw	2522	1	In	in	IN
cord-001835-0s7ok4uw	2522	2	2011	2011	CD
cord-001835-0s7ok4uw	2522	3	,	,	,
cord-001835-0s7ok4uw	2522	4	the	the	DT
cord-001835-0s7ok4uw	2522	5	Grasby	Grasby	NNP
cord-001835-0s7ok4uw	2522	6	and	and	CC
cord-001835-0s7ok4uw	2522	7	Tainer	Tainer	NNP
cord-001835-0s7ok4uw	2522	8	labs	lab	NNS
cord-001835-0s7ok4uw	2522	9	solved	solve	VBD
cord-001835-0s7ok4uw	2522	10	the	the	DT
cord-001835-0s7ok4uw	2522	11	structures	structure	NNS
cord-001835-0s7ok4uw	2522	12	of	of	IN
cord-001835-0s7ok4uw	2522	13	hFEN1	hfen1	NN
cord-001835-0s7ok4uw	2522	14	in	in	IN
cord-001835-0s7ok4uw	2522	15	complex	complex	NN
cord-001835-0s7ok4uw	2522	16	with	with	IN
cord-001835-0s7ok4uw	2522	17	product	product	NN
cord-001835-0s7ok4uw	2522	18	and	and	CC
cord-001835-0s7ok4uw	2522	19	substrate	substrate	NN
cord-001835-0s7ok4uw	2522	20	.	.	.
cord-001835-0s7ok4uw	2523	1	This	this	DT
cord-001835-0s7ok4uw	2523	2	study	study	NN
cord-001835-0s7ok4uw	2523	3	revealed	reveal	VBD
cord-001835-0s7ok4uw	2523	4	that	that	IN
cord-001835-0s7ok4uw	2523	5	scissile	scissile	NN
cord-001835-0s7ok4uw	2523	6	phosphate	phosphate	NN
cord-001835-0s7ok4uw	2523	7	selectivity	selectivity	NN
cord-001835-0s7ok4uw	2523	8	is	be	VBZ
cord-001835-0s7ok4uw	2523	9	largely	largely	RB
cord-001835-0s7ok4uw	2523	10	due	due	JJ
cord-001835-0s7ok4uw	2523	11	to	to	IN
cord-001835-0s7ok4uw	2523	12	the	the	DT
cord-001835-0s7ok4uw	2523	13	substrate	substrate	NN
cord-001835-0s7ok4uw	2523	14	DNA	dna	NN
cord-001835-0s7ok4uw	2523	15	undergoing	undergo	VBG
cord-001835-0s7ok4uw	2523	16	a	a	DT
cord-001835-0s7ok4uw	2523	17	novel	novel	NN
cord-001835-0s7ok4uw	2523	18	Di	Di	NNP
cord-001835-0s7ok4uw	2523	19	-	-	HYPH
cord-001835-0s7ok4uw	2523	20	Nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	2523	21	Unpairing	Unpairing	NNP
cord-001835-0s7ok4uw	2523	22	(	(	-LRB-
cord-001835-0s7ok4uw	2523	23	DNU	DNU	NNP
cord-001835-0s7ok4uw	2523	24	)	)	-RRB-
cord-001835-0s7ok4uw	2523	25	,	,	,
cord-001835-0s7ok4uw	2523	26	which	which	WDT
cord-001835-0s7ok4uw	2523	27	places	place	VBZ
cord-001835-0s7ok4uw	2523	28	the	the	DT
cord-001835-0s7ok4uw	2523	29	scissile	scissile	NNP
cord-001835-0s7ok4uw	2523	30	phosphate	phosphate	NN
cord-001835-0s7ok4uw	2523	31	diester	diester	NN
cord-001835-0s7ok4uw	2523	32	in	in	IN
cord-001835-0s7ok4uw	2523	33	contact	contact	NN
cord-001835-0s7ok4uw	2523	34	with	with	IN
cord-001835-0s7ok4uw	2523	35	the	the	DT
cord-001835-0s7ok4uw	2523	36	requisite	requisite	JJ
cord-001835-0s7ok4uw	2523	37	divalent	divalent	JJ
cord-001835-0s7ok4uw	2523	38	metal	metal	NN
cord-001835-0s7ok4uw	2523	39	ions	ion	NNS
cord-001835-0s7ok4uw	2523	40	.	.	.
cord-001835-0s7ok4uw	2524	1	In	in	IN
cord-001835-0s7ok4uw	2524	2	addition	addition	NN
cord-001835-0s7ok4uw	2524	3	,	,	,
cord-001835-0s7ok4uw	2524	4	by	by	IN
cord-001835-0s7ok4uw	2524	5	comparing	compare	VBG
cord-001835-0s7ok4uw	2524	6	the	the	DT
cord-001835-0s7ok4uw	2524	7	structures	structure	NNS
cord-001835-0s7ok4uw	2524	8	of	of	IN
cord-001835-0s7ok4uw	2524	9	hFEN1	hfen1	NN
cord-001835-0s7ok4uw	2525	1	alone	alone	JJ
cord-001835-0s7ok4uw	2525	2	(	(	-LRB-
cord-001835-0s7ok4uw	2525	3	2	2	LS
cord-001835-0s7ok4uw	2525	4	)	)	-RRB-
cord-001835-0s7ok4uw	2525	5	and	and	CC
cord-001835-0s7ok4uw	2525	6	in	in	IN
cord-001835-0s7ok4uw	2525	7	complex	complex	NN
cord-001835-0s7ok4uw	2525	8	with	with	IN
cord-001835-0s7ok4uw	2525	9	substrate	substrate	NN
cord-001835-0s7ok4uw	2525	10	and	and	CC
cord-001835-0s7ok4uw	2525	11	product	product	NN
cord-001835-0s7ok4uw	2525	12	DNAs	dna	NNS
cord-001835-0s7ok4uw	2525	13	(	(	-LRB-
cord-001835-0s7ok4uw	2525	14	3	3	CD
cord-001835-0s7ok4uw	2525	15	)	)	-RRB-
cord-001835-0s7ok4uw	2525	16	,	,	,
cord-001835-0s7ok4uw	2525	17	Grasby	Grasby	NNP
cord-001835-0s7ok4uw	2525	18	and	and	CC
cord-001835-0s7ok4uw	2525	19	Tainer	Tainer	NNP
cord-001835-0s7ok4uw	2525	20	proposed	propose	VBD
cord-001835-0s7ok4uw	2525	21	a	a	DT
cord-001835-0s7ok4uw	2525	22	model	model	NN
cord-001835-0s7ok4uw	2525	23	,	,	,
cord-001835-0s7ok4uw	2525	24	whereby	whereby	WRB
cord-001835-0s7ok4uw	2525	25	protein	protein	NN
cord-001835-0s7ok4uw	2525	26	conformational	conformational	JJ
cord-001835-0s7ok4uw	2525	27	changes	change	NNS
cord-001835-0s7ok4uw	2525	28	occur	occur	VBP
cord-001835-0s7ok4uw	2525	29	upon	upon	IN
cord-001835-0s7ok4uw	2525	30	binding	bind	VBG
cord-001835-0s7ok4uw	2525	31	substrate	substrate	NN
cord-001835-0s7ok4uw	2525	32	resulting	result	VBG
cord-001835-0s7ok4uw	2525	33	in	in	IN
cord-001835-0s7ok4uw	2525	34	placement	placement	NN
cord-001835-0s7ok4uw	2525	35	of	of	IN
cord-001835-0s7ok4uw	2525	36	key	key	JJ
cord-001835-0s7ok4uw	2525	37	basic	basic	JJ
cord-001835-0s7ok4uw	2525	38	residues	residue	NNS
cord-001835-0s7ok4uw	2525	39	that	that	WDT
cord-001835-0s7ok4uw	2525	40	position	position	NN
cord-001835-0s7ok4uw	2525	41	and/or	and/or	CC
cord-001835-0s7ok4uw	2525	42	electrophillically	electrophillically	RB
cord-001835-0s7ok4uw	2525	43	catalyse	catalyse	VB
cord-001835-0s7ok4uw	2525	44	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	2525	45	of	of	IN
cord-001835-0s7ok4uw	2525	46	the	the	DT
cord-001835-0s7ok4uw	2525	47	scissile	scissile	NNP
cord-001835-0s7ok4uw	2525	48	phosphate	phosphate	NN
cord-001835-0s7ok4uw	2525	49	diester	diester	NNP
cord-001835-0s7ok4uw	2525	50	.	.	.
cord-001835-0s7ok4uw	2526	1	Further	further	JJ
cord-001835-0s7ok4uw	2526	2	work	work	NN
cord-001835-0s7ok4uw	2526	3	using	use	VBG
cord-001835-0s7ok4uw	2526	4	a	a	DT
cord-001835-0s7ok4uw	2526	5	CD	cd	NN
cord-001835-0s7ok4uw	2526	6	-	-	HYPH
cord-001835-0s7ok4uw	2526	7	based	base	VBN
cord-001835-0s7ok4uw	2526	8	assay	assay	NN
cord-001835-0s7ok4uw	2526	9	showed	show	VBD
cord-001835-0s7ok4uw	2526	10	that	that	IN
cord-001835-0s7ok4uw	2526	11	metals	metal	NNS
cord-001835-0s7ok4uw	2526	12	are	be	VBP
cord-001835-0s7ok4uw	2526	13	absolutely	absolutely	RB
cord-001835-0s7ok4uw	2526	14	required	require	VBN
cord-001835-0s7ok4uw	2526	15	for	for	IN
cord-001835-0s7ok4uw	2526	16	DNU	DNU	NNP
cord-001835-0s7ok4uw	2526	17	,	,	,
cord-001835-0s7ok4uw	2526	18	whereas	whereas	IN
cord-001835-0s7ok4uw	2526	19	the	the	DT
cord-001835-0s7ok4uw	2526	20	key	key	JJ
cord-001835-0s7ok4uw	2526	21	basic	basic	JJ
cord-001835-0s7ok4uw	2526	22	residues	residue	NNS
cord-001835-0s7ok4uw	2526	23	in	in	IN
cord-001835-0s7ok4uw	2526	24	the	the	DT
cord-001835-0s7ok4uw	2526	25	active	active	JJ
cord-001835-0s7ok4uw	2526	26	site	site	NN
cord-001835-0s7ok4uw	2526	27	are	be	VBP
cord-001835-0s7ok4uw	2526	28	not	not	RB
cord-001835-0s7ok4uw	2526	29	.	.	.
cord-001835-0s7ok4uw	2527	1	Surprisingly	surprisingly	RB
cord-001835-0s7ok4uw	2527	2	,	,	,
cord-001835-0s7ok4uw	2527	3	perturbations	perturbation	NNS
cord-001835-0s7ok4uw	2527	4	to	to	IN
cord-001835-0s7ok4uw	2527	5	the	the	DT
cord-001835-0s7ok4uw	2527	6	protein	protein	NN
cord-001835-0s7ok4uw	2527	7	structure	structure	NN
cord-001835-0s7ok4uw	2527	8	that	that	WDT
cord-001835-0s7ok4uw	2527	9	are	be	VBP
cord-001835-0s7ok4uw	2527	10	much	much	RB
cord-001835-0s7ok4uw	2527	11	more	more	RBR
cord-001835-0s7ok4uw	2527	12	distant	distant	JJ
cord-001835-0s7ok4uw	2527	13	from	from	IN
cord-001835-0s7ok4uw	2527	14	the	the	DT
cord-001835-0s7ok4uw	2527	15	FEN1	FEN1	NNP
cord-001835-0s7ok4uw	2527	16	active	active	JJ
cord-001835-0s7ok4uw	2527	17	site	site	NN
cord-001835-0s7ok4uw	2527	18	(	(	-LRB-
cord-001835-0s7ok4uw	2527	19	i.e.	i.e.	FW
cord-001835-0s7ok4uw	2527	20	,	,	,
cord-001835-0s7ok4uw	2527	21	helical	helical	JJ
cord-001835-0s7ok4uw	2527	22	cap	cap	NN
cord-001835-0s7ok4uw	2527	23	)	)	-RRB-
cord-001835-0s7ok4uw	2527	24	prevent	prevent	VB
cord-001835-0s7ok4uw	2527	25	DNA	dna	NN
cord-001835-0s7ok4uw	2527	26	unpairing	unpairing	NN
cord-001835-0s7ok4uw	2527	27	,	,	,
cord-001835-0s7ok4uw	2527	28	implying	imply	VBG
cord-001835-0s7ok4uw	2527	29	that	that	IN
cord-001835-0s7ok4uw	2527	30	the	the	DT
cord-001835-0s7ok4uw	2527	31	FEN1	FEN1	NNP
cord-001835-0s7ok4uw	2527	32	protein	protein	NN
cord-001835-0s7ok4uw	2527	33	actively	actively	RB
cord-001835-0s7ok4uw	2527	34	participates	participate	VBZ
cord-001835-0s7ok4uw	2527	35	in	in	IN
cord-001835-0s7ok4uw	2527	36	the	the	DT
cord-001835-0s7ok4uw	2527	37	unpairing	unpairing	JJ
cord-001835-0s7ok4uw	2527	38	process	process	NN
cord-001835-0s7ok4uw	2527	39	(	(	-LRB-
cord-001835-0s7ok4uw	2527	40	4,5	4,5	CD
cord-001835-0s7ok4uw	2527	41	)	)	-RRB-
cord-001835-0s7ok4uw	2527	42	;	;	:
cord-001835-0s7ok4uw	2527	43	however	however	RB
cord-001835-0s7ok4uw	2527	44	,	,	,
cord-001835-0s7ok4uw	2527	45	how	how	WRB
cord-001835-0s7ok4uw	2527	46	it	-PRON-	PRP
cord-001835-0s7ok4uw	2527	47	does	do	VBZ
cord-001835-0s7ok4uw	2527	48	remains	remain	VBZ
cord-001835-0s7ok4uw	2527	49	a	a	DT
cord-001835-0s7ok4uw	2527	50	mystery	mystery	NN
cord-001835-0s7ok4uw	2527	51	.	.	.
cord-001835-0s7ok4uw	2528	1	The	the	DT
cord-001835-0s7ok4uw	2528	2	maximal	maximal	JJ
cord-001835-0s7ok4uw	2528	3	multiple	multiple	JJ
cord-001835-0s7ok4uw	2528	4	turnover	turnover	NN
cord-001835-0s7ok4uw	2528	5	rate	rate	NN
cord-001835-0s7ok4uw	2528	6	of	of	IN
cord-001835-0s7ok4uw	2528	7	hFEN1	hfen1	NN
cord-001835-0s7ok4uw	2528	8	reaction	reaction	NN
cord-001835-0s7ok4uw	2528	9	is	be	VBZ
cord-001835-0s7ok4uw	2528	10	rate	rate	NN
cord-001835-0s7ok4uw	2528	11	-	-	HYPH
cord-001835-0s7ok4uw	2528	12	limited	limit	VBN
cord-001835-0s7ok4uw	2528	13	by	by	IN
cord-001835-0s7ok4uw	2528	14	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2528	15	product	product	NN
cord-001835-0s7ok4uw	2528	16	release	release	NN
cord-001835-0s7ok4uw	2528	17	,	,	,
cord-001835-0s7ok4uw	2528	18	whereas	whereas	IN
cord-001835-0s7ok4uw	2528	19	hFEN1	hfen1	NN
cord-001835-0s7ok4uw	2528	20	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2528	21	under	under	IN
cord-001835-0s7ok4uw	2528	22	substrate	substrate	NN
cord-001835-0s7ok4uw	2528	23	-	-	HYPH
cord-001835-0s7ok4uw	2528	24	limiting	limit	VBG
cord-001835-0s7ok4uw	2528	25	conditions	condition	NNS
cord-001835-0s7ok4uw	2528	26	(	(	-LRB-
cord-001835-0s7ok4uw	2528	27	[	[	-LRB-
cord-001835-0s7ok4uw	2528	28	E]<[S]<Km	e]<[s]<km	NN
cord-001835-0s7ok4uw	2528	29	)	)	-RRB-
cord-001835-0s7ok4uw	2528	30	suggest	suggest	VBP
cord-001835-0s7ok4uw	2528	31	that	that	IN
cord-001835-0s7ok4uw	2528	32	the	the	DT
cord-001835-0s7ok4uw	2528	33	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2528	34	is	be	VBZ
cord-001835-0s7ok4uw	2528	35	approaching	approach	VBG
cord-001835-0s7ok4uw	2528	36	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2528	37	perfection	perfection	NN
cord-001835-0s7ok4uw	2528	38	(	(	-LRB-
cord-001835-0s7ok4uw	2528	39	i.e.	i.e.	FW
cord-001835-0s7ok4uw	2528	40	,	,	,
cord-001835-0s7ok4uw	2528	41	almost	almost	RB
cord-001835-0s7ok4uw	2528	42	diffusion	diffusion	NN
cord-001835-0s7ok4uw	2528	43	controlled	control	VBN
cord-001835-0s7ok4uw	2528	44	-10exp7	-10exp7	NNP
cord-001835-0s7ok4uw	2528	45	M-1s-1	M-1s-1	NNP
cord-001835-0s7ok4uw	2528	46	)	)	-RRB-
cord-001835-0s7ok4uw	2529	1	(	(	-LRB-
cord-001835-0s7ok4uw	2529	2	6	6	CD
cord-001835-0s7ok4uw	2529	3	)	)	-RRB-
cord-001835-0s7ok4uw	2529	4	.	.	.
cord-001835-0s7ok4uw	2530	1	Previous	previous	JJ
cord-001835-0s7ok4uw	2530	2	work	work	NN
cord-001835-0s7ok4uw	2530	3	has	have	VBZ
cord-001835-0s7ok4uw	2530	4	shown	show	VBN
cord-001835-0s7ok4uw	2530	5	that	that	IN
cord-001835-0s7ok4uw	2530	6	a	a	DT
cord-001835-0s7ok4uw	2530	7	paralogue	paralogue	NN
cord-001835-0s7ok4uw	2530	8	of	of	IN
cord-001835-0s7ok4uw	2530	9	hFEN1	hfen1	NN
cord-001835-0s7ok4uw	2530	10	(	(	-LRB-
cord-001835-0s7ok4uw	2530	11	i.e.	i.e.	FW
cord-001835-0s7ok4uw	2530	12	,	,	,
cord-001835-0s7ok4uw	2530	13	T5	T5	NNP
cord-001835-0s7ok4uw	2530	14	FEN1	FEN1	NNP
cord-001835-0s7ok4uw	2530	15	)	)	-RRB-
cord-001835-0s7ok4uw	2530	16	is	be	VBZ
cord-001835-0s7ok4uw	2530	17	not	not	RB
cord-001835-0s7ok4uw	2530	18	ratelimited	ratelimite	VBN
cord-001835-0s7ok4uw	2530	19	by	by	IN
cord-001835-0s7ok4uw	2530	20	chemistry	chemistry	NN
cord-001835-0s7ok4uw	2530	21	under	under	IN
cord-001835-0s7ok4uw	2530	22	single	single	JJ
cord-001835-0s7ok4uw	2530	23	turnover	turnover	NN
cord-001835-0s7ok4uw	2530	24	(	(	-LRB-
cord-001835-0s7ok4uw	2530	25	ST	ST	NNP
cord-001835-0s7ok4uw	2530	26	)	)	-RRB-
cord-001835-0s7ok4uw	2530	27	conditions	condition	NNS
cord-001835-0s7ok4uw	2530	28	,	,	,
cord-001835-0s7ok4uw	2530	29	but	but	CC
cord-001835-0s7ok4uw	2531	1	rather	rather	RB
cord-001835-0s7ok4uw	2531	2	some	some	DT
cord-001835-0s7ok4uw	2531	3	physical	physical	JJ
cord-001835-0s7ok4uw	2531	4	limitation	limitation	NN
cord-001835-0s7ok4uw	2531	5	such	such	JJ
cord-001835-0s7ok4uw	2531	6	as	as	IN
cord-001835-0s7ok4uw	2531	7	conformational	conformational	JJ
cord-001835-0s7ok4uw	2531	8	change	change	NN
cord-001835-0s7ok4uw	2531	9	(	(	-LRB-
cord-001835-0s7ok4uw	2531	10	6	6	CD
cord-001835-0s7ok4uw	2531	11	)	)	-RRB-
cord-001835-0s7ok4uw	2531	12	.	.	.
cord-001835-0s7ok4uw	2532	1	To	to	TO
cord-001835-0s7ok4uw	2532	2	ascertain	ascertain	VB
cord-001835-0s7ok4uw	2532	3	whether	whether	IN
cord-001835-0s7ok4uw	2532	4	the	the	DT
cord-001835-0s7ok4uw	2532	5	protein	protein	NN
cord-001835-0s7ok4uw	2532	6	and/or	and/or	CC
cord-001835-0s7ok4uw	2532	7	DNA	dna	NN
cord-001835-0s7ok4uw	2532	8	conformational	conformational	JJ
cord-001835-0s7ok4uw	2532	9	changes	change	NNS
cord-001835-0s7ok4uw	2532	10	of	of	IN
cord-001835-0s7ok4uw	2532	11	hFEN1	hfen1	NN
cord-001835-0s7ok4uw	2532	12	mentioned	mention	VBN
cord-001835-0s7ok4uw	2532	13	above	above	RB
cord-001835-0s7ok4uw	2532	14	are	be	VBP
cord-001835-0s7ok4uw	2532	15	rate	rate	NN
cord-001835-0s7ok4uw	2532	16	limiting	limit	VBG
cord-001835-0s7ok4uw	2532	17	under	under	IN
cord-001835-0s7ok4uw	2532	18	ST	ST	NNP
cord-001835-0s7ok4uw	2532	19	conditions	condition	NNS
cord-001835-0s7ok4uw	2532	20	,	,	,
cord-001835-0s7ok4uw	2532	21	we	-PRON-	PRP
cord-001835-0s7ok4uw	2532	22	have	have	VBP
cord-001835-0s7ok4uw	2532	23	initiated	initiate	VBN
cord-001835-0s7ok4uw	2532	24	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	2532	25	and	and	CC
cord-001835-0s7ok4uw	2532	26	NMR	NMR	NNP
cord-001835-0s7ok4uw	2532	27	studies	study	NNS
cord-001835-0s7ok4uw	2532	28	to	to	TO
cord-001835-0s7ok4uw	2532	29	determine	determine	VB
cord-001835-0s7ok4uw	2532	30	the	the	DT
cord-001835-0s7ok4uw	2532	31	role	role	NN
cord-001835-0s7ok4uw	2532	32	of	of	IN
cord-001835-0s7ok4uw	2532	33	conformational	conformational	JJ
cord-001835-0s7ok4uw	2532	34	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2532	35	in	in	IN
cord-001835-0s7ok4uw	2532	36	the	the	DT
cord-001835-0s7ok4uw	2532	37	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2532	38	cycle	cycle	NN
cord-001835-0s7ok4uw	2532	39	of	of	IN
cord-001835-0s7ok4uw	2532	40	hFEN1	hfen1	NN
cord-001835-0s7ok4uw	2532	41	.	.	.
cord-001835-0s7ok4uw	2532	42	 	 	_SP
cord-001835-0s7ok4uw	2533	1	Owing	owe	VBG
cord-001835-0s7ok4uw	2533	2	to	to	IN
cord-001835-0s7ok4uw	2533	3	the	the	DT
cord-001835-0s7ok4uw	2533	4	latest	late	JJS
cord-001835-0s7ok4uw	2533	5	advance	advance	NN
cord-001835-0s7ok4uw	2533	6	in	in	IN
cord-001835-0s7ok4uw	2533	7	the	the	DT
cord-001835-0s7ok4uw	2533	8	computational	computational	JJ
cord-001835-0s7ok4uw	2533	9	technologies	technology	NNS
cord-001835-0s7ok4uw	2533	10	of	of	IN
cord-001835-0s7ok4uw	2533	11	microprocessor	microprocessor	NN
cord-001835-0s7ok4uw	2533	12	,	,	,
cord-001835-0s7ok4uw	2533	13	high	high	JJ
cord-001835-0s7ok4uw	2533	14	-	-	HYPH
cord-001835-0s7ok4uw	2533	15	speed	speed	NN
cord-001835-0s7ok4uw	2533	16	inter	inter	JJ
cord-001835-0s7ok4uw	2533	17	-	-	JJ
cord-001835-0s7ok4uw	2533	18	processor	processor	JJ
cord-001835-0s7ok4uw	2533	19	connection	connection	NN
cord-001835-0s7ok4uw	2533	20	,	,	,
cord-001835-0s7ok4uw	2533	21	and	and	CC
cord-001835-0s7ok4uw	2533	22	parallelization	parallelization	NN
cord-001835-0s7ok4uw	2533	23	algorithm	algorithm	NN
cord-001835-0s7ok4uw	2533	24	,	,	,
cord-001835-0s7ok4uw	2533	25	all	all	DT
cord-001835-0s7ok4uw	2533	26	-	-	HYPH
cord-001835-0s7ok4uw	2533	27	atom	atom	NN
cord-001835-0s7ok4uw	2533	28	molecular	molecular	JJ
cord-001835-0s7ok4uw	2533	29	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2533	30	(	(	-LRB-
cord-001835-0s7ok4uw	2533	31	MD	MD	NNP
cord-001835-0s7ok4uw	2533	32	)	)	-RRB-
cord-001835-0s7ok4uw	2533	33	simulations	simulation	NNS
cord-001835-0s7ok4uw	2533	34	of	of	IN
cord-001835-0s7ok4uw	2533	35	microsecond	microsecond	NN
cord-001835-0s7ok4uw	2533	36	time	time	NN
cord-001835-0s7ok4uw	2533	37	scale	scale	NN
cord-001835-0s7ok4uw	2533	38	are	be	VBP
cord-001835-0s7ok4uw	2533	39	getting	get	VBG
cord-001835-0s7ok4uw	2533	40	popular	popular	JJ
cord-001835-0s7ok4uw	2533	41	to	to	TO
cord-001835-0s7ok4uw	2533	42	study	study	VB
cord-001835-0s7ok4uw	2533	43	the	the	DT
cord-001835-0s7ok4uw	2533	44	pharmaceutical	pharmaceutical	NN
cord-001835-0s7ok4uw	2533	45	target	target	NN
cord-001835-0s7ok4uw	2533	46	proteins	protein	NNS
cord-001835-0s7ok4uw	2533	47	.	.	.
cord-001835-0s7ok4uw	2534	1	An	an	DT
cord-001835-0s7ok4uw	2534	2	antibody	antibody	NN
cord-001835-0s7ok4uw	2534	3	binds	bind	VBZ
cord-001835-0s7ok4uw	2534	4	to	to	IN
cord-001835-0s7ok4uw	2534	5	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2534	6	antigen	antigen	NN
cord-001835-0s7ok4uw	2534	7	with	with	IN
cord-001835-0s7ok4uw	2534	8	structure	structure	NN
cord-001835-0s7ok4uw	2534	9	changes	change	NNS
cord-001835-0s7ok4uw	2534	10	.	.	.
cord-001835-0s7ok4uw	2535	1	A	a	DT
cord-001835-0s7ok4uw	2535	2	small	small	JJ
cord-001835-0s7ok4uw	2535	3	molecule	molecule	NN
cord-001835-0s7ok4uw	2535	4	moves	move	NNS
cord-001835-0s7ok4uw	2535	5	around	around	IN
cord-001835-0s7ok4uw	2535	6	the	the	DT
cord-001835-0s7ok4uw	2535	7	target	target	NN
cord-001835-0s7ok4uw	2535	8	protein	protein	NN
cord-001835-0s7ok4uw	2535	9	and	and	CC
cord-001835-0s7ok4uw	2535	10	finds	find	VBZ
cord-001835-0s7ok4uw	2535	11	an	an	DT
cord-001835-0s7ok4uw	2535	12	entrance	entrance	NN
cord-001835-0s7ok4uw	2535	13	to	to	TO
cord-001835-0s7ok4uw	2535	14	get	get	VB
cord-001835-0s7ok4uw	2535	15	into	into	IN
cord-001835-0s7ok4uw	2535	16	the	the	DT
cord-001835-0s7ok4uw	2535	17	binding	binding	NN
cord-001835-0s7ok4uw	2535	18	site	site	NN
cord-001835-0s7ok4uw	2535	19	.	.	.
cord-001835-0s7ok4uw	2536	1	These	these	DT
cord-001835-0s7ok4uw	2536	2	phenomena	phenomenon	NNS
cord-001835-0s7ok4uw	2536	3	can	can	MD
cord-001835-0s7ok4uw	2536	4	be	be	VB
cord-001835-0s7ok4uw	2536	5	observed	observe	VBN
cord-001835-0s7ok4uw	2536	6	in	in	IN
cord-001835-0s7ok4uw	2536	7	microsecond	microsecond	NN
cord-001835-0s7ok4uw	2536	8	simulations	simulation	NNS
cord-001835-0s7ok4uw	2536	9	,	,	,
cord-001835-0s7ok4uw	2536	10	but	but	CC
cord-001835-0s7ok4uw	2536	11	the	the	DT
cord-001835-0s7ok4uw	2536	12	vital	vital	JJ
cord-001835-0s7ok4uw	2536	13	issue	issue	NN
cord-001835-0s7ok4uw	2536	14	is	be	VBZ
cord-001835-0s7ok4uw	2536	15	whether	whether	IN
cord-001835-0s7ok4uw	2536	16	the	the	DT
cord-001835-0s7ok4uw	2536	17	adopted	adopt	VBN
cord-001835-0s7ok4uw	2536	18	force	force	NN
cord-001835-0s7ok4uw	2536	19	field	field	NN
cord-001835-0s7ok4uw	2536	20	is	be	VBZ
cord-001835-0s7ok4uw	2536	21	enough	enough	RB
cord-001835-0s7ok4uw	2536	22	accurate	accurate	JJ
cord-001835-0s7ok4uw	2536	23	to	to	TO
cord-001835-0s7ok4uw	2536	24	correctly	correctly	RB
cord-001835-0s7ok4uw	2536	25	describe	describe	VB
cord-001835-0s7ok4uw	2536	26	the	the	DT
cord-001835-0s7ok4uw	2536	27	phenomena	phenomena	NN
cord-001835-0s7ok4uw	2536	28	.	.	.
cord-001835-0s7ok4uw	2537	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2537	2	are	be	VBP
cord-001835-0s7ok4uw	2537	3	developing	develop	VBG
cord-001835-0s7ok4uw	2537	4	a	a	DT
cord-001835-0s7ok4uw	2537	5	force	force	NN
cord-001835-0s7ok4uw	2537	6	field	field	NN
cord-001835-0s7ok4uw	2537	7	(	(	-LRB-
cord-001835-0s7ok4uw	2537	8	FUJI	FUJI	NNP
cord-001835-0s7ok4uw	2537	9	)	)	-RRB-
cord-001835-0s7ok4uw	2537	10	based	base	VBN
cord-001835-0s7ok4uw	2537	11	on	on	IN
cord-001835-0s7ok4uw	2537	12	general	general	JJ
cord-001835-0s7ok4uw	2537	13	AMBER	AMBER	NNP
cord-001835-0s7ok4uw	2537	14	atom	atom	NN
cord-001835-0s7ok4uw	2537	15	types	type	NNS
cord-001835-0s7ok4uw	2537	16	and	and	CC
cord-001835-0s7ok4uw	2537	17	AMBER94	amber94	NN
cord-001835-0s7ok4uw	2537	18	van	van	NNP
cord-001835-0s7ok4uw	2537	19	der	der	NNP
cord-001835-0s7ok4uw	2537	20	Waals	Waals	NNP
cord-001835-0s7ok4uw	2537	21	parameters	parameter	NNS
cord-001835-0s7ok4uw	2537	22	in	in	IN
cord-001835-0s7ok4uw	2537	23	order	order	NN
cord-001835-0s7ok4uw	2537	24	to	to	TO
cord-001835-0s7ok4uw	2537	25	describe	describe	VB
cord-001835-0s7ok4uw	2537	26	arbitrary	arbitrary	JJ
cord-001835-0s7ok4uw	2537	27	organic	organic	JJ
cord-001835-0s7ok4uw	2537	28	molecules	molecule	NNS
cord-001835-0s7ok4uw	2537	29	in	in	IN
cord-001835-0s7ok4uw	2537	30	a	a	DT
cord-001835-0s7ok4uw	2537	31	unified	unified	JJ
cord-001835-0s7ok4uw	2537	32	manner	manner	NN
cord-001835-0s7ok4uw	2537	33	including	include	VBG
cord-001835-0s7ok4uw	2537	34	proteins	protein	NNS
cord-001835-0s7ok4uw	2537	35	and	and	CC
cord-001835-0s7ok4uw	2537	36	nucleic	nucleic	JJ
cord-001835-0s7ok4uw	2537	37	acids	acid	NNS
cord-001835-0s7ok4uw	2537	38	.	.	.
cord-001835-0s7ok4uw	2538	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2538	2	use	use	VBP
cord-001835-0s7ok4uw	2538	3	the	the	DT
cord-001835-0s7ok4uw	2538	4	first	first	JJ
cord-001835-0s7ok4uw	2538	5	principle	principle	JJ
cord-001835-0s7ok4uw	2538	6	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	2538	7	method	method	NN
cord-001835-0s7ok4uw	2538	8	to	to	TO
cord-001835-0s7ok4uw	2538	9	refine	refine	VB
cord-001835-0s7ok4uw	2538	10	the	the	DT
cord-001835-0s7ok4uw	2538	11	force	force	NN
cord-001835-0s7ok4uw	2538	12	field	field	NN
cord-001835-0s7ok4uw	2538	13	in	in	IN
cord-001835-0s7ok4uw	2538	14	contrast	contrast	NN
cord-001835-0s7ok4uw	2538	15	to	to	IN
cord-001835-0s7ok4uw	2538	16	common	common	JJ
cord-001835-0s7ok4uw	2538	17	empirical	empirical	JJ
cord-001835-0s7ok4uw	2538	18	fittings	fitting	NNS
cord-001835-0s7ok4uw	2538	19	to	to	IN
cord-001835-0s7ok4uw	2538	20	experimental	experimental	JJ
cord-001835-0s7ok4uw	2538	21	data	datum	NNS
cord-001835-0s7ok4uw	2538	22	.	.	.
cord-001835-0s7ok4uw	2539	1	The	the	DT
cord-001835-0s7ok4uw	2539	2	dihedral	dihedral	JJ
cord-001835-0s7ok4uw	2539	3	torsion	torsion	NN
cord-001835-0s7ok4uw	2539	4	parameters	parameter	NNS
cord-001835-0s7ok4uw	2539	5	of	of	IN
cord-001835-0s7ok4uw	2539	6	protein	protein	NN
cord-001835-0s7ok4uw	2539	7	backbone	backbone	NN
cord-001835-0s7ok4uw	2539	8	were	be	VBD
cord-001835-0s7ok4uw	2539	9	determined	determined	JJ
cord-001835-0s7ok4uw	2539	10	to	to	TO
cord-001835-0s7ok4uw	2539	11	agree	agree	VB
cord-001835-0s7ok4uw	2539	12	with	with	IN
cord-001835-0s7ok4uw	2539	13	the	the	DT
cord-001835-0s7ok4uw	2539	14	torsion	torsion	NN
cord-001835-0s7ok4uw	2539	15	energy	energy	NN
cord-001835-0s7ok4uw	2539	16	profiles	profile	NNS
cord-001835-0s7ok4uw	2539	17	calculated	calculate	VBN
cord-001835-0s7ok4uw	2539	18	by	by	IN
cord-001835-0s7ok4uw	2539	19	high	high	JJ
cord-001835-0s7ok4uw	2539	20	-	-	HYPH
cord-001835-0s7ok4uw	2539	21	level	level	NN
cord-001835-0s7ok4uw	2539	22	quantum	quantum	NN
cord-001835-0s7ok4uw	2539	23	mechanical	mechanical	JJ
cord-001835-0s7ok4uw	2539	24	theory	theory	NN
cord-001835-0s7ok4uw	2539	25	for	for	IN
cord-001835-0s7ok4uw	2539	26	the	the	DT
cord-001835-0s7ok4uw	2539	27	model	model	NN
cord-001835-0s7ok4uw	2539	28	systems	system	NNS
cord-001835-0s7ok4uw	2539	29	of	of	IN
cord-001835-0s7ok4uw	2539	30	protein	protein	NN
cord-001835-0s7ok4uw	2539	31	backbone	backbone	NN
cord-001835-0s7ok4uw	2539	32	.	.	.
cord-001835-0s7ok4uw	2540	1	Conformational	Conformational	NNP
cord-001835-0s7ok4uw	2540	2	preferences	preference	NNS
cord-001835-0s7ok4uw	2540	3	of	of	IN
cord-001835-0s7ok4uw	2540	4	dipeptides	dipeptide	NNS
cord-001835-0s7ok4uw	2540	5	in	in	IN
cord-001835-0s7ok4uw	2540	6	water	water	NN
cord-001835-0s7ok4uw	2540	7	were	be	VBD
cord-001835-0s7ok4uw	2540	8	measured	measure	VBN
cord-001835-0s7ok4uw	2540	9	by	by	IN
cord-001835-0s7ok4uw	2540	10	vibrational	vibrational	JJ
cord-001835-0s7ok4uw	2540	11	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2540	12	.	.	.
cord-001835-0s7ok4uw	2541	1	Comparing	compare	VBG
cord-001835-0s7ok4uw	2541	2	with	with	IN
cord-001835-0s7ok4uw	2541	3	the	the	DT
cord-001835-0s7ok4uw	2541	4	experimental	experimental	JJ
cord-001835-0s7ok4uw	2541	5	distribution	distribution	NN
cord-001835-0s7ok4uw	2541	6	of	of	IN
cord-001835-0s7ok4uw	2541	7	Ramachandran	Ramachandran	NNP
cord-001835-0s7ok4uw	2541	8	angles	angle	NNS
cord-001835-0s7ok4uw	2541	9	of	of	IN
cord-001835-0s7ok4uw	2541	10	dipeptides	dipeptide	NNS
cord-001835-0s7ok4uw	2541	11	,	,	,
cord-001835-0s7ok4uw	2541	12	how	how	WRB
cord-001835-0s7ok4uw	2541	13	accurately	accurately	RB
cord-001835-0s7ok4uw	2541	14	molecular	molecular	JJ
cord-001835-0s7ok4uw	2541	15	calculations	calculation	NNS
cord-001835-0s7ok4uw	2541	16	predict	predict	VBP
cord-001835-0s7ok4uw	2541	17	the	the	DT
cord-001835-0s7ok4uw	2541	18	conformation	conformation	NN
cord-001835-0s7ok4uw	2541	19	distribution	distribution	NN
cord-001835-0s7ok4uw	2541	20	of	of	IN
cord-001835-0s7ok4uw	2541	21	dipeptides	dipeptide	NNS
cord-001835-0s7ok4uw	2541	22	were	be	VBD
cord-001835-0s7ok4uw	2541	23	investigated	investigate	VBN
cord-001835-0s7ok4uw	2541	24	for	for	IN
cord-001835-0s7ok4uw	2541	25	various	various	JJ
cord-001835-0s7ok4uw	2541	26	force	force	NN
cord-001835-0s7ok4uw	2541	27	fields	field	NNS
cord-001835-0s7ok4uw	2541	28	and	and	CC
cord-001835-0s7ok4uw	2541	29	semiempirical	semiempirical	JJ
cord-001835-0s7ok4uw	2541	30	quantum	quantum	NN
cord-001835-0s7ok4uw	2541	31	methods	method	NNS
cord-001835-0s7ok4uw	2541	32	.	.	.
cord-001835-0s7ok4uw	2542	1	FUJI	FUJI	NNP
cord-001835-0s7ok4uw	2542	2	force	force	NN
cord-001835-0s7ok4uw	2542	3	field	field	NN
cord-001835-0s7ok4uw	2542	4	gave	give	VBD
cord-001835-0s7ok4uw	2542	5	the	the	DT
cord-001835-0s7ok4uw	2542	6	best	good	JJS
cord-001835-0s7ok4uw	2542	7	prediction	prediction	NN
cord-001835-0s7ok4uw	2542	8	score	score	NN
cord-001835-0s7ok4uw	2542	9	among	among	IN
cord-001835-0s7ok4uw	2542	10	the	the	DT
cord-001835-0s7ok4uw	2542	11	various	various	JJ
cord-001835-0s7ok4uw	2542	12	methods	method	NNS
cord-001835-0s7ok4uw	2542	13	(	(	-LRB-
cord-001835-0s7ok4uw	2542	14	Tzanov	Tzanov	NNP
cord-001835-0s7ok4uw	2542	15	et	et	FW
cord-001835-0s7ok4uw	2542	16	al	al	NNP
cord-001835-0s7ok4uw	2542	17	,	,	,
cord-001835-0s7ok4uw	2542	18	2014	2014	CD
cord-001835-0s7ok4uw	2542	19	)	)	-RRB-
cord-001835-0s7ok4uw	2542	20	.	.	.
cord-001835-0s7ok4uw	2543	1	In	in	IN
cord-001835-0s7ok4uw	2543	2	this	this	DT
cord-001835-0s7ok4uw	2543	3	work	work	NN
cord-001835-0s7ok4uw	2543	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	2543	5	examine	examine	VBP
cord-001835-0s7ok4uw	2543	6	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	2543	7	structure	structure	NN
cord-001835-0s7ok4uw	2543	8	behaviors	behavior	NNS
cord-001835-0s7ok4uw	2543	9	of	of	IN
cord-001835-0s7ok4uw	2543	10	pharmaceutical	pharmaceutical	JJ
cord-001835-0s7ok4uw	2543	11	target	target	NN
cord-001835-0s7ok4uw	2543	12	proteins	protein	NNS
cord-001835-0s7ok4uw	2543	13	by	by	IN
cord-001835-0s7ok4uw	2543	14	microsecond	microsecond	NN
cord-001835-0s7ok4uw	2543	15	MD	MD	NNP
cord-001835-0s7ok4uw	2543	16	simulations	simulation	NNS
cord-001835-0s7ok4uw	2543	17	with	with	IN
cord-001835-0s7ok4uw	2543	18	FUJI	FUJI	NNP
cord-001835-0s7ok4uw	2543	19	force	force	NN
cord-001835-0s7ok4uw	2543	20	field	field	NN
cord-001835-0s7ok4uw	2543	21	.	.	.
cord-001835-0s7ok4uw	2544	1	Epiregulin	Epiregulin	NNP
cord-001835-0s7ok4uw	2544	2	(	(	-LRB-
cord-001835-0s7ok4uw	2544	3	EPR	EPR	NNP
cord-001835-0s7ok4uw	2544	4	)	)	-RRB-
cord-001835-0s7ok4uw	2544	5	is	be	VBZ
cord-001835-0s7ok4uw	2544	6	a	a	DT
cord-001835-0s7ok4uw	2544	7	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	2544	8	protein	protein	NN
cord-001835-0s7ok4uw	2544	9	with	with	IN
cord-001835-0s7ok4uw	2544	10	140	140	CD
cord-001835-0s7ok4uw	2544	11	residues	residue	NNS
cord-001835-0s7ok4uw	2544	12	belonging	belong	VBG
cord-001835-0s7ok4uw	2544	13	to	to	IN
cord-001835-0s7ok4uw	2544	14	the	the	DT
cord-001835-0s7ok4uw	2544	15	epidermal	epidermal	JJ
cord-001835-0s7ok4uw	2544	16	growth	growth	NN
cord-001835-0s7ok4uw	2544	17	factor	factor	NN
cord-001835-0s7ok4uw	2544	18	family	family	NN
cord-001835-0s7ok4uw	2544	19	.	.	.
cord-001835-0s7ok4uw	2545	1	Mature	mature	JJ
cord-001835-0s7ok4uw	2545	2	EPR	EPR	NNP
cord-001835-0s7ok4uw	2545	3	(	(	-LRB-
cord-001835-0s7ok4uw	2545	4	46	46	CD
cord-001835-0s7ok4uw	2545	5	residues	residue	NNS
cord-001835-0s7ok4uw	2545	6	)	)	-RRB-
cord-001835-0s7ok4uw	2545	7	binds	bind	VBZ
cord-001835-0s7ok4uw	2545	8	to	to	IN
cord-001835-0s7ok4uw	2545	9	epidermal	epidermal	JJ
cord-001835-0s7ok4uw	2545	10	growth	growth	NN
cord-001835-0s7ok4uw	2545	11	factor	factor	NN
cord-001835-0s7ok4uw	2545	12	receptor	receptor	NN
cord-001835-0s7ok4uw	2545	13	(	(	-LRB-
cord-001835-0s7ok4uw	2545	14	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	2545	15	)	)	-RRB-
cord-001835-0s7ok4uw	2545	16	,	,	,
cord-001835-0s7ok4uw	2545	17	which	which	WDT
cord-001835-0s7ok4uw	2545	18	stimulates	stimulate	VBZ
cord-001835-0s7ok4uw	2545	19	the	the	DT
cord-001835-0s7ok4uw	2545	20	proliferative	proliferative	JJ
cord-001835-0s7ok4uw	2545	21	signaling	signaling	NN
cord-001835-0s7ok4uw	2545	22	in	in	IN
cord-001835-0s7ok4uw	2545	23	cancer	cancer	NN
cord-001835-0s7ok4uw	2545	24	cells	cell	NNS
cord-001835-0s7ok4uw	2545	25	.	.	.
cord-001835-0s7ok4uw	2546	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2546	2	EPR	EPR	NNP
cord-001835-0s7ok4uw	2546	3	antibody	antibody	NN
cord-001835-0s7ok4uw	2546	4	has	have	VBZ
cord-001835-0s7ok4uw	2546	5	a	a	DT
cord-001835-0s7ok4uw	2546	6	proline	proline	NN
cord-001835-0s7ok4uw	2546	7	at	at	IN
cord-001835-0s7ok4uw	2546	8	the	the	DT
cord-001835-0s7ok4uw	2546	9	residue	residue	NN
cord-001835-0s7ok4uw	2546	10	103	103	CD
cord-001835-0s7ok4uw	2546	11	in	in	IN
cord-001835-0s7ok4uw	2546	12	the	the	DT
cord-001835-0s7ok4uw	2546	13	third	third	JJ
cord-001835-0s7ok4uw	2546	14	complementarity	complementarity	NN
cord-001835-0s7ok4uw	2546	15	-	-	HYPH
cord-001835-0s7ok4uw	2546	16	determining	determine	VBG
cord-001835-0s7ok4uw	2546	17	region	region	NN
cord-001835-0s7ok4uw	2546	18	(	(	-LRB-
cord-001835-0s7ok4uw	2546	19	CDR	CDR	NNP
cord-001835-0s7ok4uw	2546	20	)	)	-RRB-
cord-001835-0s7ok4uw	2546	21	of	of	IN
cord-001835-0s7ok4uw	2546	22	the	the	DT
cord-001835-0s7ok4uw	2546	23	heavy	heavy	JJ
cord-001835-0s7ok4uw	2546	24	chain	chain	NN
cord-001835-0s7ok4uw	2546	25	,	,	,
cord-001835-0s7ok4uw	2546	26	which	which	WDT
cord-001835-0s7ok4uw	2546	27	has	have	VBZ
cord-001835-0s7ok4uw	2546	28	cis	cis	NNP
cord-001835-0s7ok4uw	2546	29	peptide	peptide	JJ
cord-001835-0s7ok4uw	2546	30	bond	bond	NN
cord-001835-0s7ok4uw	2546	31	in	in	IN
cord-001835-0s7ok4uw	2546	32	free	free	JJ
cord-001835-0s7ok4uw	2546	33	state	state	NN
cord-001835-0s7ok4uw	2546	34	and	and	CC
cord-001835-0s7ok4uw	2546	35	trans	trans	NNP
cord-001835-0s7ok4uw	2546	36	one	one	CD
cord-001835-0s7ok4uw	2546	37	in	in	IN
cord-001835-0s7ok4uw	2546	38	the	the	DT
cord-001835-0s7ok4uw	2546	39	bound	bind	VBN
cord-001835-0s7ok4uw	2546	40	state	state	NN
cord-001835-0s7ok4uw	2546	41	with	with	IN
cord-001835-0s7ok4uw	2546	42	EPR	EPR	NNP
cord-001835-0s7ok4uw	2546	43	according	accord	VBG
cord-001835-0s7ok4uw	2546	44	to	to	IN
cord-001835-0s7ok4uw	2546	45	X	x	NN
cord-001835-0s7ok4uw	2546	46	-	-	NN
cord-001835-0s7ok4uw	2546	47	ray	ray	NN
cord-001835-0s7ok4uw	2546	48	crystallography	crystallography	NN
cord-001835-0s7ok4uw	2546	49	analysis	analysis	NN
cord-001835-0s7ok4uw	2546	50	.	.	.
cord-001835-0s7ok4uw	2547	1	In	in	IN
cord-001835-0s7ok4uw	2547	2	order	order	NN
cord-001835-0s7ok4uw	2547	3	to	to	TO
cord-001835-0s7ok4uw	2547	4	clarify	clarify	VB
cord-001835-0s7ok4uw	2547	5	the	the	DT
cord-001835-0s7ok4uw	2547	6	structure	structure	NN
cord-001835-0s7ok4uw	2547	7	changes	change	NNS
cord-001835-0s7ok4uw	2547	8	in	in	IN
cord-001835-0s7ok4uw	2547	9	binding	bind	VBG
cord-001835-0s7ok4uw	2547	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	2547	11	performed	perform	VBD
cord-001835-0s7ok4uw	2547	12	extensive	extensive	JJ
cord-001835-0s7ok4uw	2547	13	MD	MD	NNP
cord-001835-0s7ok4uw	2547	14	simulations	simulation	NNS
cord-001835-0s7ok4uw	2547	15	of	of	IN
cord-001835-0s7ok4uw	2547	16	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2547	17	antibody	antibody	NN
cord-001835-0s7ok4uw	2547	18	(	(	-LRB-
cord-001835-0s7ok4uw	2547	19	fab	fab	JJ
cord-001835-0s7ok4uw	2547	20	;	;	:
cord-001835-0s7ok4uw	2547	21	436	436	CD
cord-001835-0s7ok4uw	2547	22	residues	residue	NNS
cord-001835-0s7ok4uw	2547	23	)	)	-RRB-
cord-001835-0s7ok4uw	2547	24	and	and	CC
cord-001835-0s7ok4uw	2547	25	EPR	EPR	NNP
cord-001835-0s7ok4uw	2547	26	.	.	.
cord-001835-0s7ok4uw	2548	1	The	the	DT
cord-001835-0s7ok4uw	2548	2	total	total	JJ
cord-001835-0s7ok4uw	2548	3	simulation	simulation	NN
cord-001835-0s7ok4uw	2548	4	time	time	NN
cord-001835-0s7ok4uw	2548	5	was	be	VBD
cord-001835-0s7ok4uw	2548	6	about	about	RB
cord-001835-0s7ok4uw	2548	7	240	240	CD
cord-001835-0s7ok4uw	2548	8	microseconds	microsecond	NNS
cord-001835-0s7ok4uw	2548	9	.	.	.
cord-001835-0s7ok4uw	2549	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2549	2	also	also	RB
cord-001835-0s7ok4uw	2549	3	performed	perform	VBD
cord-001835-0s7ok4uw	2549	4	MD	MD	NNP
cord-001835-0s7ok4uw	2549	5	simulations	simulation	NNS
cord-001835-0s7ok4uw	2549	6	for	for	IN
cord-001835-0s7ok4uw	2549	7	a	a	DT
cord-001835-0s7ok4uw	2549	8	protein	protein	NN
cord-001835-0s7ok4uw	2549	9	kinase	kinase	NN
cord-001835-0s7ok4uw	2549	10	and	and	CC
cord-001835-0s7ok4uw	2549	11	a	a	DT
cord-001835-0s7ok4uw	2549	12	small	small	JJ
cord-001835-0s7ok4uw	2549	13	molecule	molecule	NN
cord-001835-0s7ok4uw	2549	14	.	.	.
cord-001835-0s7ok4uw	2550	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2550	2	show	show	VBP
cord-001835-0s7ok4uw	2550	3	how	how	WRB
cord-001835-0s7ok4uw	2550	4	the	the	DT
cord-001835-0s7ok4uw	2550	5	complex	complex	JJ
cord-001835-0s7ok4uw	2550	6	system	system	NN
cord-001835-0s7ok4uw	2550	7	reaches	reach	VBZ
cord-001835-0s7ok4uw	2550	8	thermal	thermal	JJ
cord-001835-0s7ok4uw	2550	9	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	2550	10	states	state	NNS
cord-001835-0s7ok4uw	2550	11	in	in	IN
cord-001835-0s7ok4uw	2550	12	simulations	simulation	NNS
cord-001835-0s7ok4uw	2550	13	from	from	IN
cord-001835-0s7ok4uw	2550	14	the	the	DT
cord-001835-0s7ok4uw	2550	15	stiff	stiff	JJ
cord-001835-0s7ok4uw	2550	16	X	x	NN
cord-001835-0s7ok4uw	2550	17	-	-	NN
cord-001835-0s7ok4uw	2550	18	ray	ray	NN
cord-001835-0s7ok4uw	2550	19	crystal	crystal	NN
cord-001835-0s7ok4uw	2550	20	structure	structure	NN
cord-001835-0s7ok4uw	2550	21	.	.	.
cord-001835-0s7ok4uw	2551	1	The	the	DT
cord-001835-0s7ok4uw	2551	2	calculations	calculation	NNS
cord-001835-0s7ok4uw	2551	3	are	be	VBP
cord-001835-0s7ok4uw	2551	4	compared	compare	VBN
cord-001835-0s7ok4uw	2551	5	with	with	IN
cord-001835-0s7ok4uw	2551	6	experiments	experiment	NNS
cord-001835-0s7ok4uw	2551	7	such	such	JJ
cord-001835-0s7ok4uw	2551	8	as	as	IN
cord-001835-0s7ok4uw	2551	9	X	x	NN
cord-001835-0s7ok4uw	2551	10	-	-	NN
cord-001835-0s7ok4uw	2551	11	ray	ray	NN
cord-001835-0s7ok4uw	2551	12	crystal	crystal	NN
cord-001835-0s7ok4uw	2551	13	structures	structure	NNS
cord-001835-0s7ok4uw	2551	14	and	and	CC
cord-001835-0s7ok4uw	2551	15	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	2551	16	quantities	quantity	NNS
cord-001835-0s7ok4uw	2551	17	measured	measure	VBN
cord-001835-0s7ok4uw	2551	18	by	by	IN
cord-001835-0s7ok4uw	2551	19	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	2551	20	titration	titration	NN
cord-001835-0s7ok4uw	2551	21	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	2551	22	(	(	-LRB-
cord-001835-0s7ok4uw	2551	23	ITC	ITC	NNP
cord-001835-0s7ok4uw	2551	24	)	)	-RRB-
cord-001835-0s7ok4uw	2551	25	and	and	CC
cord-001835-0s7ok4uw	2551	26	surface	surface	VB
cord-001835-0s7ok4uw	2551	27	plasmon	plasmon	JJ
cord-001835-0s7ok4uw	2551	28	resonance	resonance	NN
cord-001835-0s7ok4uw	2551	29	(	(	-LRB-
cord-001835-0s7ok4uw	2551	30	SPR	SPR	NNP
cord-001835-0s7ok4uw	2551	31	)	)	-RRB-
cord-001835-0s7ok4uw	2551	32	.	.	.
cord-001835-0s7ok4uw	2552	1	This	this	DT
cord-001835-0s7ok4uw	2552	2	research	research	NN
cord-001835-0s7ok4uw	2552	3	has	have	VBZ
cord-001835-0s7ok4uw	2552	4	been	be	VBN
cord-001835-0s7ok4uw	2552	5	supported	support	VBN
cord-001835-0s7ok4uw	2552	6	by	by	IN
cord-001835-0s7ok4uw	2552	7	MEXT	MEXT	NNP
cord-001835-0s7ok4uw	2552	8	SPIRE	SPIRE	NNP
cord-001835-0s7ok4uw	2552	9	Supercomputational	Supercomputational	NNP
cord-001835-0s7ok4uw	2552	10	Life	Life	NNP
cord-001835-0s7ok4uw	2552	11	Science	Science	NNP
cord-001835-0s7ok4uw	2552	12	(	(	-LRB-
cord-001835-0s7ok4uw	2552	13	hp130006	hp130006	FW
cord-001835-0s7ok4uw	2552	14	,	,	,
cord-001835-0s7ok4uw	2552	15	hp140228	hp140228	NNP
cord-001835-0s7ok4uw	2552	16	)	)	-RRB-
cord-001835-0s7ok4uw	2552	17	and	and	CC
cord-001835-0s7ok4uw	2552	18	FIRST	FIRST	NNP
cord-001835-0s7ok4uw	2552	19	Kodama	Kodama	NNP
cord-001835-0s7ok4uw	2552	20	project	project	NN
cord-001835-0s7ok4uw	2552	21	in	in	IN
cord-001835-0s7ok4uw	2552	22	Japan	Japan	NNP
cord-001835-0s7ok4uw	2552	23	.	.	.
cord-001835-0s7ok4uw	2553	1	Structure	structure	NN
cord-001835-0s7ok4uw	2553	2	-	-	HYPH
cord-001835-0s7ok4uw	2553	3	based	base	VBN
cord-001835-0s7ok4uw	2553	4	recombination	recombination	NN
cord-001835-0s7ok4uw	2553	5	of	of	IN
cord-001835-0s7ok4uw	2553	6	drug	drug	NN
cord-001835-0s7ok4uw	2553	7	resistance	resistance	NN
cord-001835-0s7ok4uw	2553	8	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	2553	9	:	:	:
cord-001835-0s7ok4uw	2553	10	structural	structural	JJ
cord-001835-0s7ok4uw	2553	11	and	and	CC
cord-001835-0s7ok4uw	2553	12	functional	functional	JJ
cord-001835-0s7ok4uw	2553	13	tolerance	tolerance	NN
cord-001835-0s7ok4uw	2553	14	to	to	IN
cord-001835-0s7ok4uw	2553	15	new	new	JJ
cord-001835-0s7ok4uw	2553	16	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2553	17	in	in	IN
cord-001835-0s7ok4uw	2553	18	artificially	artificially	RB
cord-001835-0s7ok4uw	2553	19	-	-	HYPH
cord-001835-0s7ok4uw	2553	20	evolved	evolve	VBN
cord-001835-0s7ok4uw	2553	21	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	2554	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2554	2	understanding	understanding	NN
cord-001835-0s7ok4uw	2554	3	of	of	IN
cord-001835-0s7ok4uw	2554	4	the	the	DT
cord-001835-0s7ok4uw	2554	5	contribution	contribution	NN
cord-001835-0s7ok4uw	2554	6	of	of	IN
cord-001835-0s7ok4uw	2554	7	protein	protein	NN
cord-001835-0s7ok4uw	2554	8	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2554	9	to	to	TO
cord-001835-0s7ok4uw	2554	10	function	function	VB
cord-001835-0s7ok4uw	2554	11	is	be	VBZ
cord-001835-0s7ok4uw	2554	12	still	still	RB
cord-001835-0s7ok4uw	2554	13	emergent	emergent	JJ
cord-001835-0s7ok4uw	2554	14	.	.	.
cord-001835-0s7ok4uw	2555	1	In	in	IN
cord-001835-0s7ok4uw	2555	2	a	a	DT
cord-001835-0s7ok4uw	2555	3	protein	protein	NN
cord-001835-0s7ok4uw	2555	4	engineering	engineering	NN
cord-001835-0s7ok4uw	2555	5	context	context	NN
cord-001835-0s7ok4uw	2555	6	,	,	,
cord-001835-0s7ok4uw	2555	7	do	do	VBP
cord-001835-0s7ok4uw	2555	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	2555	9	need	need	VB
cord-001835-0s7ok4uw	2555	10	to	to	TO
cord-001835-0s7ok4uw	2555	11	take	take	VB
cord-001835-0s7ok4uw	2555	12	into	into	IN
cord-001835-0s7ok4uw	2555	13	account	account	NN
cord-001835-0s7ok4uw	2555	14	the	the	DT
cord-001835-0s7ok4uw	2555	15	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2555	16	in	in	IN
cord-001835-0s7ok4uw	2555	17	order	order	NN
cord-001835-0s7ok4uw	2555	18	to	to	TO
cord-001835-0s7ok4uw	2555	19	maximize	maximize	VB
cord-001835-0s7ok4uw	2555	20	the	the	DT
cord-001835-0s7ok4uw	2555	21	fitness	fitness	NN
cord-001835-0s7ok4uw	2555	22	and	and	CC
cord-001835-0s7ok4uw	2555	23	function	function	NN
cord-001835-0s7ok4uw	2555	24	of	of	IN
cord-001835-0s7ok4uw	2555	25	the	the	DT
cord-001835-0s7ok4uw	2555	26	resulting	result	VBG
cord-001835-0s7ok4uw	2555	27	proteins	protein	NNS
cord-001835-0s7ok4uw	2555	28	?	?	.
cord-001835-0s7ok4uw	2556	1	Using	use	VBG
cord-001835-0s7ok4uw	2556	2	high	high	JJ
cord-001835-0s7ok4uw	2556	3	resolution	resolution	NN
cord-001835-0s7ok4uw	2556	4	crystal	crystal	NN
cord-001835-0s7ok4uw	2556	5	structures	structure	NNS
cord-001835-0s7ok4uw	2556	6	,	,	,
cord-001835-0s7ok4uw	2556	7	NMR	nmr	NN
cord-001835-0s7ok4uw	2556	8	relaxation	relaxation	NN
cord-001835-0s7ok4uw	2556	9	dispersion	dispersion	NN
cord-001835-0s7ok4uw	2556	10	and	and	CC
cord-001835-0s7ok4uw	2556	11	ms	ms	NNP
cord-001835-0s7ok4uw	2556	12	molecular	molecular	JJ
cord-001835-0s7ok4uw	2556	13	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2556	14	simulations	simulation	NNS
cord-001835-0s7ok4uw	2556	15	,	,	,
cord-001835-0s7ok4uw	2556	16	we	-PRON-	PRP
cord-001835-0s7ok4uw	2556	17	compare	compare	VBP
cord-001835-0s7ok4uw	2556	18	two	two	CD
cord-001835-0s7ok4uw	2557	1	naturally	naturally	RB
cord-001835-0s7ok4uw	2557	2	evolved	evolve	VBN
cord-001835-0s7ok4uw	2557	3	homologous	homologous	JJ
cord-001835-0s7ok4uw	2557	4	class	class	NN
cord-001835-0s7ok4uw	2557	5	A	a	NN
cord-001835-0s7ok4uw	2557	6	b	b	NN
cord-001835-0s7ok4uw	2557	7	-	-	HYPH
cord-001835-0s7ok4uw	2557	8	lactamases	lactamase	NNS
cord-001835-0s7ok4uw	2557	9	,	,	,
cord-001835-0s7ok4uw	2557	10	TEM-1	TEM-1	NNP
cord-001835-0s7ok4uw	2557	11	and	and	CC
cord-001835-0s7ok4uw	2557	12	PSE-4	PSE-4	NNP
cord-001835-0s7ok4uw	2557	13	which	which	WDT
cord-001835-0s7ok4uw	2557	14	share	share	VBP
cord-001835-0s7ok4uw	2557	15	a	a	DT
cord-001835-0s7ok4uw	2557	16	high	high	JJ
cord-001835-0s7ok4uw	2557	17	degree	degree	NN
cord-001835-0s7ok4uw	2557	18	of	of	IN
cord-001835-0s7ok4uw	2557	19	structural	structural	JJ
cord-001835-0s7ok4uw	2557	20	and	and	CC
cord-001835-0s7ok4uw	2557	21	functional	functional	JJ
cord-001835-0s7ok4uw	2557	22	conservation	conservation	NN
cord-001835-0s7ok4uw	2557	23	.	.	.
cord-001835-0s7ok4uw	2558	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2558	2	observed	observe	VBD
cord-001835-0s7ok4uw	2558	3	a	a	DT
cord-001835-0s7ok4uw	2558	4	conservation	conservation	NN
cord-001835-0s7ok4uw	2558	5	of	of	IN
cord-001835-0s7ok4uw	2558	6	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2558	7	on	on	IN
cord-001835-0s7ok4uw	2558	8	a	a	DT
cord-001835-0s7ok4uw	2558	9	catalytically	catalytically	RB
cord-001835-0s7ok4uw	2558	10	relevant	relevant	JJ
cord-001835-0s7ok4uw	2558	11	timescale	timescale	NN
cord-001835-0s7ok4uw	2558	12	.	.	.
cord-001835-0s7ok4uw	2559	1	This	this	DT
cord-001835-0s7ok4uw	2559	2	is	be	VBZ
cord-001835-0s7ok4uw	2559	3	consistent	consistent	JJ
cord-001835-0s7ok4uw	2559	4	with	with	IN
cord-001835-0s7ok4uw	2559	5	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2559	6	being	be	VBG
cord-001835-0s7ok4uw	2559	7	an	an	DT
cord-001835-0s7ok4uw	2559	8	evolutionarily	evolutionarily	RB
cord-001835-0s7ok4uw	2559	9	conserved	conserve	VBN
cord-001835-0s7ok4uw	2559	10	feature	feature	NN
cord-001835-0s7ok4uw	2559	11	.	.	.
cord-001835-0s7ok4uw	2560	1	However	however	RB
cord-001835-0s7ok4uw	2560	2	,	,	,
cord-001835-0s7ok4uw	2560	3	laboratory	laboratory	NN
cord-001835-0s7ok4uw	2560	4	-	-	HYPH
cord-001835-0s7ok4uw	2560	5	engineered	engineer	VBN
cord-001835-0s7ok4uw	2560	6	chimeric	chimeric	JJ
cord-001835-0s7ok4uw	2560	7	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	2560	8	obtained	obtain	VBN
cord-001835-0s7ok4uw	2560	9	by	by	IN
cord-001835-0s7ok4uw	2560	10	recombination	recombination	NN
cord-001835-0s7ok4uw	2560	11	of	of	IN
cord-001835-0s7ok4uw	2560	12	the	the	DT
cord-001835-0s7ok4uw	2560	13	two	two	CD
cord-001835-0s7ok4uw	2560	14	homologs	homolog	NNS
cord-001835-0s7ok4uw	2560	15	exhibit	exhibit	VBP
cord-001835-0s7ok4uw	2560	16	striking	strike	VBG
cord-001835-0s7ok4uw	2560	17	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2560	18	differences	difference	NNS
cord-001835-0s7ok4uw	2560	19	,	,	,
cord-001835-0s7ok4uw	2560	20	despite	despite	IN
cord-001835-0s7ok4uw	2560	21	the	the	DT
cord-001835-0s7ok4uw	2560	22	function	function	NN
cord-001835-0s7ok4uw	2560	23	and	and	CC
cord-001835-0s7ok4uw	2560	24	structure	structure	NN
cord-001835-0s7ok4uw	2560	25	being	be	VBG
cord-001835-0s7ok4uw	2560	26	conserved	conserve	VBN
cord-001835-0s7ok4uw	2560	27	.	.	.
cord-001835-0s7ok4uw	2561	1	The	the	DT
cord-001835-0s7ok4uw	2561	2	laboratory	laboratory	NN
cord-001835-0s7ok4uw	2561	3	-	-	HYPH
cord-001835-0s7ok4uw	2561	4	engineered	engineer	VBN
cord-001835-0s7ok4uw	2561	5	chimeras	chimera	NNS
cord-001835-0s7ok4uw	2561	6	are	be	VBP
cord-001835-0s7ok4uw	2561	7	thus	thus	RB
cord-001835-0s7ok4uw	2561	8	functionally	functionally	RB
cord-001835-0s7ok4uw	2561	9	and	and	CC
cord-001835-0s7ok4uw	2561	10	structurally	structurally	RB
cord-001835-0s7ok4uw	2561	11	tolerant	tolerant	JJ
cord-001835-0s7ok4uw	2561	12	to	to	IN
cord-001835-0s7ok4uw	2561	13	modified	modify	VBN
cord-001835-0s7ok4uw	2561	14	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2561	15	on	on	IN
cord-001835-0s7ok4uw	2561	16	the	the	DT
cord-001835-0s7ok4uw	2561	17	timescale	timescale	NN
cord-001835-0s7ok4uw	2561	18	of	of	IN
cord-001835-0s7ok4uw	2561	19	the	the	DT
cord-001835-0s7ok4uw	2561	20	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2561	21	turnover	turnover	NN
cord-001835-0s7ok4uw	2561	22	.	.	.
cord-001835-0s7ok4uw	2562	1	This	this	DT
cord-001835-0s7ok4uw	2562	2	tolerance	tolerance	NN
cord-001835-0s7ok4uw	2562	3	of	of	IN
cord-001835-0s7ok4uw	2562	4	blactamases	blactamase	NNS
cord-001835-0s7ok4uw	2562	5	to	to	IN
cord-001835-0s7ok4uw	2562	6	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2562	7	changes	change	NNS
cord-001835-0s7ok4uw	2562	8	could	could	MD
cord-001835-0s7ok4uw	2562	9	be	be	VB
cord-001835-0s7ok4uw	2562	10	linked	link	VBN
cord-001835-0s7ok4uw	2562	11	to	to	IN
cord-001835-0s7ok4uw	2562	12	the	the	DT
cord-001835-0s7ok4uw	2562	13	high	high	JJ
cord-001835-0s7ok4uw	2562	14	fitness	fitness	NN
cord-001835-0s7ok4uw	2562	15	of	of	IN
cord-001835-0s7ok4uw	2562	16	the	the	DT
cord-001835-0s7ok4uw	2562	17	naturally	naturally	RB
cord-001835-0s7ok4uw	2562	18	evolved	evolve	VBN
cord-001835-0s7ok4uw	2562	19	proteins	protein	NNS
cord-001835-0s7ok4uw	2562	20	and	and	CC
cord-001835-0s7ok4uw	2562	21	implies	imply	VBZ
cord-001835-0s7ok4uw	2562	22	that	that	IN
cord-001835-0s7ok4uw	2562	23	maintenance	maintenance	NN
cord-001835-0s7ok4uw	2562	24	of	of	IN
cord-001835-0s7ok4uw	2562	25	native	native	JJ
cord-001835-0s7ok4uw	2562	26	-	-	HYPH
cord-001835-0s7ok4uw	2562	27	like	like	JJ
cord-001835-0s7ok4uw	2562	28	protein	protein	NN
cord-001835-0s7ok4uw	2562	29	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2562	30	may	may	MD
cord-001835-0s7ok4uw	2562	31	not	not	RB
cord-001835-0s7ok4uw	2562	32	be	be	VB
cord-001835-0s7ok4uw	2562	33	essential	essential	JJ
cord-001835-0s7ok4uw	2562	34	when	when	WRB
cord-001835-0s7ok4uw	2562	35	engineering	engineer	VBG
cord-001835-0s7ok4uw	2562	36	functional	functional	JJ
cord-001835-0s7ok4uw	2562	37	proteins	protein	NNS
cord-001835-0s7ok4uw	2562	38	.	.	.
cord-001835-0s7ok4uw	2563	1	Conformations	conformation	NNS
cord-001835-0s7ok4uw	2563	2	solution	solution	NN
cord-001835-0s7ok4uw	2563	3	.	.	.
cord-001835-0s7ok4uw	2564	1	An	an	DT
cord-001835-0s7ok4uw	2564	2	immense	immense	JJ
cord-001835-0s7ok4uw	2564	3	advantage	advantage	NN
cord-001835-0s7ok4uw	2564	4	of	of	IN
cord-001835-0s7ok4uw	2564	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2564	6	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	2564	7	system	system	NN
cord-001835-0s7ok4uw	2564	8	is	be	VBZ
cord-001835-0s7ok4uw	2564	9	the	the	DT
cord-001835-0s7ok4uw	2564	10	possibility	possibility	NN
cord-001835-0s7ok4uw	2564	11	to	to	TO
cord-001835-0s7ok4uw	2564	12	perturb	perturb	VB
cord-001835-0s7ok4uw	2564	13	it	-PRON-	PRP
cord-001835-0s7ok4uw	2564	14	by	by	IN
cord-001835-0s7ok4uw	2564	15	introducing	introduce	VBG
cord-001835-0s7ok4uw	2564	16	unnatural	unnatural	JJ
cord-001835-0s7ok4uw	2564	17	amino	amino	JJ
cord-001835-0s7ok4uw	2564	18	acids	acid	NNS
cord-001835-0s7ok4uw	2564	19	for	for	IN
cord-001835-0s7ok4uw	2564	20	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	2564	21	labelling	labelling	NN
cord-001835-0s7ok4uw	2564	22	with	with	IN
cord-001835-0s7ok4uw	2564	23	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	2564	24	dyes	dye	NNS
cord-001835-0s7ok4uw	2564	25	or	or	CC
cord-001835-0s7ok4uw	2564	26	to	to	TO
cord-001835-0s7ok4uw	2564	27	omit	omit	VB
cord-001835-0s7ok4uw	2564	28	subunits	subunit	NNS
cord-001835-0s7ok4uw	2564	29	from	from	IN
cord-001835-0s7ok4uw	2564	30	the	the	DT
cord-001835-0s7ok4uw	2564	31	multisubunit	multisubunit	NNP
cord-001835-0s7ok4uw	2564	32	RNAP	RNAP	NNP
cord-001835-0s7ok4uw	2564	33	.	.	.
cord-001835-0s7ok4uw	2565	1	Comparing	compare	VBG
cord-001835-0s7ok4uw	2565	2	free	free	JJ
cord-001835-0s7ok4uw	2565	3	,	,	,
cord-001835-0s7ok4uw	2565	4	nucleic	nucleic	JJ
cord-001835-0s7ok4uw	2565	5	acid	acid	NN
cord-001835-0s7ok4uw	2565	6	-	-	HYPH
cord-001835-0s7ok4uw	2565	7	and	and	CC
cord-001835-0s7ok4uw	2565	8	factor	factor	NN
cord-001835-0s7ok4uw	2565	9	-	-	HYPH
cord-001835-0s7ok4uw	2565	10	bound	bind	VBN
cord-001835-0s7ok4uw	2565	11	RNAP	RNAP	NNP
cord-001835-0s7ok4uw	2565	12	complexes	complex	NNS
cord-001835-0s7ok4uw	2565	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	2565	14	found	find	VBD
cord-001835-0s7ok4uw	2565	15	that	that	IN
cord-001835-0s7ok4uw	2565	16	the	the	DT
cord-001835-0s7ok4uw	2565	17	position	position	NN
cord-001835-0s7ok4uw	2565	18	of	of	IN
cord-001835-0s7ok4uw	2565	19	the	the	DT
cord-001835-0s7ok4uw	2565	20	clamp	clamp	NN
cord-001835-0s7ok4uw	2565	21	is	be	VBZ
cord-001835-0s7ok4uw	2565	22	modulated	modulate	VBN
cord-001835-0s7ok4uw	2565	23	during	during	IN
cord-001835-0s7ok4uw	2565	24	the	the	DT
cord-001835-0s7ok4uw	2565	25	transcription	transcription	NN
cord-001835-0s7ok4uw	2565	26	cycle	cycle	NN
cord-001835-0s7ok4uw	2565	27	in	in	IN
cord-001835-0s7ok4uw	2565	28	a	a	DT
cord-001835-0s7ok4uw	2565	29	fashion	fashion	NN
cord-001835-0s7ok4uw	2565	30	exceeding	exceed	VBG
cord-001835-0s7ok4uw	2565	31	the	the	DT
cord-001835-0s7ok4uw	2565	32	simplified	simplified	JJ
cord-001835-0s7ok4uw	2565	33	closed	closed	JJ
cord-001835-0s7ok4uw	2565	34	-	-	HYPH
cord-001835-0s7ok4uw	2565	35	open	open	JJ
cord-001835-0s7ok4uw	2565	36	picture	picture	NN
cord-001835-0s7ok4uw	2565	37	drawn	draw	VBN
cord-001835-0s7ok4uw	2565	38	from	from	IN
cord-001835-0s7ok4uw	2565	39	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	2565	40	studies	study	NNS
cord-001835-0s7ok4uw	2565	41	.	.	.
cord-001835-0s7ok4uw	2566	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2566	2	show	show	VBP
cord-001835-0s7ok4uw	2566	3	that	that	IN
cord-001835-0s7ok4uw	2566	4	the	the	DT
cord-001835-0s7ok4uw	2566	5	clamp	clamp	NN
cord-001835-0s7ok4uw	2566	6	adopts	adopt	VBZ
cord-001835-0s7ok4uw	2566	7	at	at	RB
cord-001835-0s7ok4uw	2566	8	least	least	JJS
cord-001835-0s7ok4uw	2566	9	two	two	CD
cord-001835-0s7ok4uw	2566	10	distinct	distinct	JJ
cord-001835-0s7ok4uw	2566	11	conformations	conformation	NNS
cord-001835-0s7ok4uw	2566	12	in	in	IN
cord-001835-0s7ok4uw	2566	13	both	both	DT
cord-001835-0s7ok4uw	2566	14	initiation	initiation	NN
cord-001835-0s7ok4uw	2566	15	and	and	CC
cord-001835-0s7ok4uw	2566	16	elongation	elongation	NN
cord-001835-0s7ok4uw	2566	17	complexes	complex	NNS
cord-001835-0s7ok4uw	2566	18	.	.	.
cord-001835-0s7ok4uw	2567	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	2567	2	,	,	,
cord-001835-0s7ok4uw	2567	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2567	4	were	be	VBD
cord-001835-0s7ok4uw	2567	5	able	able	JJ
cord-001835-0s7ok4uw	2567	6	to	to	TO
cord-001835-0s7ok4uw	2567	7	link	link	VB
cord-001835-0s7ok4uw	2567	8	conformational	conformational	JJ
cord-001835-0s7ok4uw	2567	9	states	state	NNS
cord-001835-0s7ok4uw	2567	10	to	to	IN
cord-001835-0s7ok4uw	2567	11	the	the	DT
cord-001835-0s7ok4uw	2567	12	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2567	13	activity	activity	NN
cord-001835-0s7ok4uw	2567	14	of	of	IN
cord-001835-0s7ok4uw	2567	15	the	the	DT
cord-001835-0s7ok4uw	2567	16	RNAP	RNAP	NNP
cord-001835-0s7ok4uw	2567	17	.	.	.
cord-001835-0s7ok4uw	2568	1	Transcription	transcription	NN
cord-001835-0s7ok4uw	2568	2	factors	factor	NNS
cord-001835-0s7ok4uw	2568	3	TFE	TFE	NNP
cord-001835-0s7ok4uw	2568	4	and	and	CC
cord-001835-0s7ok4uw	2568	5	Spt4/5	Spt4/5	NNP
cord-001835-0s7ok4uw	2568	6	,	,	,
cord-001835-0s7ok4uw	2568	7	which	which	WDT
cord-001835-0s7ok4uw	2568	8	both	both	DT
cord-001835-0s7ok4uw	2568	9	bind	bind	VBP
cord-001835-0s7ok4uw	2568	10	to	to	IN
cord-001835-0s7ok4uw	2568	11	the	the	DT
cord-001835-0s7ok4uw	2568	12	RNAP	RNAP	NNP
cord-001835-0s7ok4uw	2568	13	clamp	clamp	NN
cord-001835-0s7ok4uw	2568	14	domain	domain	NN
cord-001835-0s7ok4uw	2568	15	and	and	CC
cord-001835-0s7ok4uw	2568	16	stimulate	stimulate	VB
cord-001835-0s7ok4uw	2568	17	the	the	DT
cord-001835-0s7ok4uw	2568	18	activity	activity	NN
cord-001835-0s7ok4uw	2568	19	of	of	IN
cord-001835-0s7ok4uw	2568	20	the	the	DT
cord-001835-0s7ok4uw	2568	21	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2568	22	,	,	,
cord-001835-0s7ok4uw	2568	23	shift	shift	VB
cord-001835-0s7ok4uw	2568	24	the	the	DT
cord-001835-0s7ok4uw	2568	25	equilibria	equilibrium	NNS
cord-001835-0s7ok4uw	2568	26	towards	towards	IN
cord-001835-0s7ok4uw	2568	27	one	one	CD
cord-001835-0s7ok4uw	2568	28	of	of	IN
cord-001835-0s7ok4uw	2568	29	the	the	DT
cord-001835-0s7ok4uw	2568	30	main	main	JJ
cord-001835-0s7ok4uw	2568	31	conformations	conformation	NNS
cord-001835-0s7ok4uw	2568	32	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2568	33	that	that	IN
cord-001835-0s7ok4uw	2568	34	both	both	CC
cord-001835-0s7ok4uw	2568	35	prompt	prompt	VB
cord-001835-0s7ok4uw	2568	36	an	an	DT
cord-001835-0s7ok4uw	2568	37	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2568	38	switch	switch	NN
cord-001835-0s7ok4uw	2568	39	that	that	WDT
cord-001835-0s7ok4uw	2568	40	influences	influence	VBZ
cord-001835-0s7ok4uw	2568	41	the	the	DT
cord-001835-0s7ok4uw	2568	42	structure	structure	NN
cord-001835-0s7ok4uw	2568	43	of	of	IN
cord-001835-0s7ok4uw	2568	44	the	the	DT
cord-001835-0s7ok4uw	2568	45	RNAP	RNAP	NNP
cord-001835-0s7ok4uw	2568	46	.	.	.
cord-001835-0s7ok4uw	2569	1	Hence	hence	RB
cord-001835-0s7ok4uw	2569	2	,	,	,
cord-001835-0s7ok4uw	2569	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2569	4	data	datum	NNS
cord-001835-0s7ok4uw	2569	5	provide	provide	VBP
cord-001835-0s7ok4uw	2569	6	a	a	DT
cord-001835-0s7ok4uw	2569	7	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	2569	8	rationale	rationale	NN
cord-001835-0s7ok4uw	2569	9	for	for	IN
cord-001835-0s7ok4uw	2569	10	the	the	DT
cord-001835-0s7ok4uw	2569	11	function	function	NN
cord-001835-0s7ok4uw	2569	12	of	of	IN
cord-001835-0s7ok4uw	2569	13	these	these	DT
cord-001835-0s7ok4uw	2569	14	factors	factor	NNS
cord-001835-0s7ok4uw	2569	15	and	and	CC
cord-001835-0s7ok4uw	2569	16	provide	provide	VB
cord-001835-0s7ok4uw	2569	17	new	new	JJ
cord-001835-0s7ok4uw	2569	18	insights	insight	NNS
cord-001835-0s7ok4uw	2569	19	into	into	IN
cord-001835-0s7ok4uw	2569	20	the	the	DT
cord-001835-0s7ok4uw	2569	21	complex	complex	JJ
cord-001835-0s7ok4uw	2569	22	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2569	23	behaviour	behaviour	NN
cord-001835-0s7ok4uw	2569	24	of	of	IN
cord-001835-0s7ok4uw	2569	25	the	the	DT
cord-001835-0s7ok4uw	2569	26	transcriptional	transcriptional	JJ
cord-001835-0s7ok4uw	2569	27	machinery	machinery	NN
cord-001835-0s7ok4uw	2569	28	.	.	.
cord-001835-0s7ok4uw	2570	1	Solvent	solvent	NN
cord-001835-0s7ok4uw	2570	2	models	model	NNS
cord-001835-0s7ok4uw	2570	3	for	for	IN
cord-001835-0s7ok4uw	2570	4	protein	protein	NN
cord-001835-0s7ok4uw	2570	5	simulations	simulation	NNS
cord-001835-0s7ok4uw	2570	6	-the	-the	DT
cord-001835-0s7ok4uw	2570	7	good	good	JJ
cord-001835-0s7ok4uw	2570	8	,	,	,
cord-001835-0s7ok4uw	2570	9	the	the	DT
cord-001835-0s7ok4uw	2570	10	bad	bad	JJ
cord-001835-0s7ok4uw	2570	11	and	and	CC
cord-001835-0s7ok4uw	2570	12	the	the	DT
cord-001835-0s7ok4uw	2570	13	applications	application	NNS
cord-001835-0s7ok4uw	2570	14	Duy	Duy	NNP
cord-001835-0s7ok4uw	2570	15	Hua	Hua	NNP
cord-001835-0s7ok4uw	2570	16	1	1	CD
cord-001835-0s7ok4uw	2570	17	,	,	,
cord-001835-0s7ok4uw	2570	18	Amitava	Amitava	NNP
cord-001835-0s7ok4uw	2570	19	Roy	Roy	NNP
cord-001835-0s7ok4uw	2570	20	1	1	CD
cord-001835-0s7ok4uw	2570	21	,	,	,
cord-001835-0s7ok4uw	2571	1	He	-PRON-	PRP
cord-001835-0s7ok4uw	2571	2	Huang	Huang	NNP
cord-001835-0s7ok4uw	2571	3	1	1	CD
cord-001835-0s7ok4uw	2571	4	,	,	,
cord-001835-0s7ok4uw	2571	5	Carol	Carol	NNP
cord-001835-0s7ok4uw	2571	6	Post	Post	NNP
cord-001835-0s7ok4uw	2571	7	1	1	CD
cord-001835-0s7ok4uw	2571	8	1	1	CD
cord-001835-0s7ok4uw	2572	1	The	the	DT
cord-001835-0s7ok4uw	2572	2	solvent	solvent	NN
cord-001835-0s7ok4uw	2572	3	environment	environment	NN
cord-001835-0s7ok4uw	2572	4	plays	play	VBZ
cord-001835-0s7ok4uw	2572	5	a	a	DT
cord-001835-0s7ok4uw	2572	6	crucial	crucial	JJ
cord-001835-0s7ok4uw	2572	7	role	role	NN
cord-001835-0s7ok4uw	2572	8	in	in	IN
cord-001835-0s7ok4uw	2572	9	determining	determine	VBG
cord-001835-0s7ok4uw	2572	10	the	the	DT
cord-001835-0s7ok4uw	2572	11	structure	structure	NN
cord-001835-0s7ok4uw	2572	12	,	,	,
cord-001835-0s7ok4uw	2572	13	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2572	14	and	and	CC
cord-001835-0s7ok4uw	2572	15	function	function	NN
cord-001835-0s7ok4uw	2572	16	of	of	IN
cord-001835-0s7ok4uw	2572	17	a	a	DT
cord-001835-0s7ok4uw	2572	18	biomolecule	biomolecule	NN
cord-001835-0s7ok4uw	2572	19	.	.	.
cord-001835-0s7ok4uw	2573	1	In	in	IN
cord-001835-0s7ok4uw	2573	2	order	order	NN
cord-001835-0s7ok4uw	2573	3	to	to	TO
cord-001835-0s7ok4uw	2573	4	utilize	utilize	VB
cord-001835-0s7ok4uw	2573	5	molecular	molecular	JJ
cord-001835-0s7ok4uw	2573	6	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2573	7	(	(	-LRB-
cord-001835-0s7ok4uw	2573	8	MD	MD	NNP
cord-001835-0s7ok4uw	2573	9	)	)	-RRB-
cord-001835-0s7ok4uw	2573	10	simulations	simulation	NNS
cord-001835-0s7ok4uw	2573	11	to	to	TO
cord-001835-0s7ok4uw	2573	12	examine	examine	VB
cord-001835-0s7ok4uw	2573	13	the	the	DT
cord-001835-0s7ok4uw	2573	14	structural	structural	JJ
cord-001835-0s7ok4uw	2573	15	changes	change	NNS
cord-001835-0s7ok4uw	2573	16	ABSTRACT	abstract	JJ
cord-001835-0s7ok4uw	2573	17	of	of	IN
cord-001835-0s7ok4uw	2573	18	biomolecules	biomolecule	NNS
cord-001835-0s7ok4uw	2573	19	,	,	,
cord-001835-0s7ok4uw	2573	20	it	-PRON-	PRP
cord-001835-0s7ok4uw	2573	21	is	be	VBZ
cord-001835-0s7ok4uw	2573	22	imperative	imperative	JJ
cord-001835-0s7ok4uw	2573	23	that	that	IN
cord-001835-0s7ok4uw	2573	24	the	the	DT
cord-001835-0s7ok4uw	2573	25	solvent	solvent	NN
cord-001835-0s7ok4uw	2573	26	environment	environment	NN
cord-001835-0s7ok4uw	2573	27	be	be	VB
cord-001835-0s7ok4uw	2573	28	accurately	accurately	RB
cord-001835-0s7ok4uw	2573	29	modeled	model	VBN
cord-001835-0s7ok4uw	2573	30	.	.	.
cord-001835-0s7ok4uw	2574	1	Implicit	implicit	JJ
cord-001835-0s7ok4uw	2574	2	solvent	solvent	NN
cord-001835-0s7ok4uw	2574	3	models	model	NNS
cord-001835-0s7ok4uw	2574	4	(	(	-LRB-
cord-001835-0s7ok4uw	2574	5	ISMs	ISMs	NNP
cord-001835-0s7ok4uw	2574	6	)	)	-RRB-
cord-001835-0s7ok4uw	2574	7	,	,	,
cord-001835-0s7ok4uw	2574	8	in	in	IN
cord-001835-0s7ok4uw	2574	9	which	which	WDT
cord-001835-0s7ok4uw	2574	10	water	water	NN
cord-001835-0s7ok4uw	2574	11	molecules	molecule	NNS
cord-001835-0s7ok4uw	2574	12	are	be	VBP
cord-001835-0s7ok4uw	2574	13	absent	absent	JJ
cord-001835-0s7ok4uw	2574	14	and	and	CC
cord-001835-0s7ok4uw	2574	15	the	the	DT
cord-001835-0s7ok4uw	2574	16	solvent	solvent	NN
cord-001835-0s7ok4uw	2574	17	effect	effect	NN
cord-001835-0s7ok4uw	2574	18	is	be	VBZ
cord-001835-0s7ok4uw	2574	19	estimated	estimate	VBN
cord-001835-0s7ok4uw	2574	20	using	use	VBG
cord-001835-0s7ok4uw	2574	21	an	an	DT
cord-001835-0s7ok4uw	2574	22	energy	energy	NN
cord-001835-0s7ok4uw	2574	23	function	function	NN
cord-001835-0s7ok4uw	2574	24	,	,	,
cord-001835-0s7ok4uw	2574	25	offer	offer	VBP
cord-001835-0s7ok4uw	2574	26	a	a	DT
cord-001835-0s7ok4uw	2574	27	low	low	JJ
cord-001835-0s7ok4uw	2574	28	-	-	HYPH
cord-001835-0s7ok4uw	2574	29	cost	cost	NN
cord-001835-0s7ok4uw	2574	30	approach	approach	NN
cord-001835-0s7ok4uw	2574	31	to	to	TO
cord-001835-0s7ok4uw	2574	32	describe	describe	VB
cord-001835-0s7ok4uw	2574	33	the	the	DT
cord-001835-0s7ok4uw	2574	34	solvent	solvent	NN
cord-001835-0s7ok4uw	2574	35	environment	environment	NN
cord-001835-0s7ok4uw	2574	36	in	in	IN
cord-001835-0s7ok4uw	2574	37	MD	MD	NNP
cord-001835-0s7ok4uw	2574	38	simulations	simulation	NNS
cord-001835-0s7ok4uw	2574	39	.	.	.
cord-001835-0s7ok4uw	2575	1	ISMs	ism	NNS
cord-001835-0s7ok4uw	2575	2	have	have	VBP
cord-001835-0s7ok4uw	2575	3	been	be	VBN
cord-001835-0s7ok4uw	2575	4	used	use	VBN
cord-001835-0s7ok4uw	2575	5	for	for	IN
cord-001835-0s7ok4uw	2575	6	a	a	DT
cord-001835-0s7ok4uw	2575	7	variety	variety	NN
cord-001835-0s7ok4uw	2575	8	of	of	IN
cord-001835-0s7ok4uw	2575	9	biological	biological	JJ
cord-001835-0s7ok4uw	2575	10	studies	study	NNS
cord-001835-0s7ok4uw	2575	11	;	;	:
cord-001835-0s7ok4uw	2575	12	yet	yet	CC
cord-001835-0s7ok4uw	2575	13	,	,	,
cord-001835-0s7ok4uw	2575	14	the	the	DT
cord-001835-0s7ok4uw	2575	15	performance	performance	NN
cord-001835-0s7ok4uw	2575	16	of	of	IN
cord-001835-0s7ok4uw	2575	17	implicit	implicit	JJ
cord-001835-0s7ok4uw	2575	18	solvation	solvation	NN
cord-001835-0s7ok4uw	2575	19	methods	method	NNS
cord-001835-0s7ok4uw	2575	20	in	in	IN
cord-001835-0s7ok4uw	2575	21	capturing	capture	VBG
cord-001835-0s7ok4uw	2575	22	the	the	DT
cord-001835-0s7ok4uw	2575	23	structural	structural	JJ
cord-001835-0s7ok4uw	2575	24	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	2575	25	of	of	IN
cord-001835-0s7ok4uw	2575	26	proteins	protein	NNS
cord-001835-0s7ok4uw	2575	27	has	have	VBZ
cord-001835-0s7ok4uw	2575	28	not	not	RB
cord-001835-0s7ok4uw	2575	29	been	be	VBN
cord-001835-0s7ok4uw	2575	30	rigorously	rigorously	RB
cord-001835-0s7ok4uw	2575	31	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	2575	32	.	.	.
cord-001835-0s7ok4uw	2576	1	In	in	IN
cord-001835-0s7ok4uw	2576	2	this	this	DT
cord-001835-0s7ok4uw	2576	3	work	work	NN
cord-001835-0s7ok4uw	2576	4	,	,	,
cord-001835-0s7ok4uw	2576	5	three	three	CD
cord-001835-0s7ok4uw	2576	6	ISMs	ism	NNS
cord-001835-0s7ok4uw	2576	7	,	,	,
cord-001835-0s7ok4uw	2576	8	namely	namely	RB
cord-001835-0s7ok4uw	2576	9	GBMV	GBMV	NNP
cord-001835-0s7ok4uw	2576	10	II	II	NNP
cord-001835-0s7ok4uw	2576	11	,	,	,
cord-001835-0s7ok4uw	2576	12	FACTS	FACTS	NNP
cord-001835-0s7ok4uw	2576	13	,	,	,
cord-001835-0s7ok4uw	2576	14	and	and	CC
cord-001835-0s7ok4uw	2576	15	SCPISM	SCPISM	NNP
cord-001835-0s7ok4uw	2576	16	,	,	,
cord-001835-0s7ok4uw	2576	17	were	be	VBD
cord-001835-0s7ok4uw	2576	18	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	2576	19	for	for	IN
cord-001835-0s7ok4uw	2576	20	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2576	21	abilities	ability	NNS
cord-001835-0s7ok4uw	2576	22	to	to	TO
cord-001835-0s7ok4uw	2576	23	emulate	emulate	VB
cord-001835-0s7ok4uw	2576	24	the	the	DT
cord-001835-0s7ok4uw	2576	25	solvent	solvent	NN
cord-001835-0s7ok4uw	2576	26	environment	environment	NN
cord-001835-0s7ok4uw	2576	27	and	and	CC
cord-001835-0s7ok4uw	2576	28	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2576	29	effect	effect	NN
cord-001835-0s7ok4uw	2576	30	on	on	IN
cord-001835-0s7ok4uw	2576	31	the	the	DT
cord-001835-0s7ok4uw	2576	32	structures	structure	NNS
cord-001835-0s7ok4uw	2576	33	,	,	,
cord-001835-0s7ok4uw	2576	34	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2576	35	and	and	CC
cord-001835-0s7ok4uw	2576	36	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	2576	37	interac-	interac-	JJ
cord-001835-0s7ok4uw	2576	38	Thioredoxins	Thioredoxins	NNP
cord-001835-0s7ok4uw	2576	39	(	(	-LRB-
cord-001835-0s7ok4uw	2576	40	Trx	Trx	NNP
cord-001835-0s7ok4uw	2576	41	)	)	-RRB-
cord-001835-0s7ok4uw	2576	42	are	be	VBP
cord-001835-0s7ok4uw	2576	43	ubiquitous	ubiquitous	JJ
cord-001835-0s7ok4uw	2576	44	proteins	protein	NNS
cord-001835-0s7ok4uw	2576	45	that	that	WDT
cord-001835-0s7ok4uw	2576	46	play	play	VBP
cord-001835-0s7ok4uw	2576	47	a	a	DT
cord-001835-0s7ok4uw	2576	48	key	key	JJ
cord-001835-0s7ok4uw	2576	49	role	role	NN
cord-001835-0s7ok4uw	2576	50	in	in	IN
cord-001835-0s7ok4uw	2576	51	redox	redox	JJ
cord-001835-0s7ok4uw	2576	52	state	state	NN
cord-001835-0s7ok4uw	2576	53	regulation	regulation	NN
cord-001835-0s7ok4uw	2576	54	of	of	IN
cord-001835-0s7ok4uw	2576	55	the	the	DT
cord-001835-0s7ok4uw	2576	56	cell	cell	NN
cord-001835-0s7ok4uw	2576	57	.	.	.
cord-001835-0s7ok4uw	2577	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	2577	2	interact	interact	VBP
cord-001835-0s7ok4uw	2577	3	with	with	IN
cord-001835-0s7ok4uw	2577	4	multiple	multiple	JJ
cord-001835-0s7ok4uw	2577	5	targets	target	NNS
cord-001835-0s7ok4uw	2577	6	in	in	IN
cord-001835-0s7ok4uw	2577	7	the	the	DT
cord-001835-0s7ok4uw	2577	8	cell	cell	NN
cord-001835-0s7ok4uw	2577	9	.	.	.
cord-001835-0s7ok4uw	2578	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2578	2	group	group	NN
cord-001835-0s7ok4uw	2578	3	solved	solve	VBD
cord-001835-0s7ok4uw	2578	4	the	the	DT
cord-001835-0s7ok4uw	2578	5	structure	structure	NN
cord-001835-0s7ok4uw	2578	6	of	of	IN
cord-001835-0s7ok4uw	2578	7	S.	S.	NNP
cord-001835-0s7ok4uw	2578	8	cerevisiae	cerevisiae	NNS
cord-001835-0s7ok4uw	2578	9	(	(	-LRB-
cord-001835-0s7ok4uw	2578	10	yTrx1	yTrx1	NNP
cord-001835-0s7ok4uw	2578	11	)	)	-RRB-
cord-001835-0s7ok4uw	2578	12	and	and	CC
cord-001835-0s7ok4uw	2578	13	measured	measure	VBD
cord-001835-0s7ok4uw	2578	14	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2578	15	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2578	16	in	in	IN
cord-001835-0s7ok4uw	2578	17	different	different	JJ
cord-001835-0s7ok4uw	2578	18	timescales	timescale	NNS
cord-001835-0s7ok4uw	2578	19	(	(	-LRB-
cord-001835-0s7ok4uw	2578	20	pico	pico	NN
cord-001835-0s7ok4uw	2578	21	to	to	IN
cord-001835-0s7ok4uw	2578	22	seconds	second	NNS
cord-001835-0s7ok4uw	2578	23	)	)	-RRB-
cord-001835-0s7ok4uw	2578	24	.	.	.
cord-001835-0s7ok4uw	2579	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2579	2	is	be	VBZ
cord-001835-0s7ok4uw	2579	3	well	well	RB
cord-001835-0s7ok4uw	2579	4	established	establish	VBN
cord-001835-0s7ok4uw	2579	5	that	that	IN
cord-001835-0s7ok4uw	2579	6	the	the	DT
cord-001835-0s7ok4uw	2579	7	Asp24	Asp24	NNP
cord-001835-0s7ok4uw	2579	8	is	be	VBZ
cord-001835-0s7ok4uw	2579	9	the	the	DT
cord-001835-0s7ok4uw	2579	10	proton	proton	NN
cord-001835-0s7ok4uw	2579	11	acceptor	acceptor	NN
cord-001835-0s7ok4uw	2579	12	in	in	IN
cord-001835-0s7ok4uw	2579	13	the	the	DT
cord-001835-0s7ok4uw	2579	14	reduction	reduction	NN
cord-001835-0s7ok4uw	2579	15	process	process	NN
cord-001835-0s7ok4uw	2579	16	of	of	IN
cord-001835-0s7ok4uw	2579	17	the	the	DT
cord-001835-0s7ok4uw	2579	18	target	target	NN
cord-001835-0s7ok4uw	2579	19	protein	protein	NN
cord-001835-0s7ok4uw	2579	20	.	.	.
cord-001835-0s7ok4uw	2580	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2580	2	proposed	propose	VBD
cord-001835-0s7ok4uw	2580	3	that	that	IN
cord-001835-0s7ok4uw	2580	4	Asp24	Asp24	NNP
cord-001835-0s7ok4uw	2580	5	also	also	RB
cord-001835-0s7ok4uw	2580	6	works	work	VBZ
cord-001835-0s7ok4uw	2580	7	to	to	IN
cord-001835-0s7ok4uw	2580	8	couple	couple	NN
cord-001835-0s7ok4uw	2580	9	hydration	hydration	NN
cord-001835-0s7ok4uw	2580	10	and	and	CC
cord-001835-0s7ok4uw	2580	11	motion	motion	NN
cord-001835-0s7ok4uw	2580	12	of	of	IN
cord-001835-0s7ok4uw	2580	13	the	the	DT
cord-001835-0s7ok4uw	2580	14	interacting	interact	VBG
cord-001835-0s7ok4uw	2580	15	loops	loop	NNS
cord-001835-0s7ok4uw	2580	16	.	.	.
cord-001835-0s7ok4uw	2581	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2581	2	studied	study	VBD
cord-001835-0s7ok4uw	2581	3	conformational	conformational	JJ
cord-001835-0s7ok4uw	2581	4	motions	motion	NNS
cord-001835-0s7ok4uw	2581	5	of	of	IN
cord-001835-0s7ok4uw	2581	6	the	the	DT
cord-001835-0s7ok4uw	2581	7	residues	residue	NNS
cord-001835-0s7ok4uw	2581	8	of	of	IN
cord-001835-0s7ok4uw	2581	9	water	water	NN
cord-001835-0s7ok4uw	2581	10	cavity	cavity	NN
cord-001835-0s7ok4uw	2581	11	and	and	CC
cord-001835-0s7ok4uw	2581	12	interacting	interact	VBG
cord-001835-0s7ok4uw	2581	13	loops	loop	NNS
cord-001835-0s7ok4uw	2581	14	.	.	.
cord-001835-0s7ok4uw	2582	1	The	the	DT
cord-001835-0s7ok4uw	2582	2	water	water	NN
cord-001835-0s7ok4uw	2582	3	molecules	molecule	NNS
cord-001835-0s7ok4uw	2582	4	in	in	IN
cord-001835-0s7ok4uw	2582	5	water	water	NN
cord-001835-0s7ok4uw	2582	6	cavity	cavity	NN
cord-001835-0s7ok4uw	2582	7	of	of	IN
cord-001835-0s7ok4uw	2582	8	the	the	DT
cord-001835-0s7ok4uw	2582	9	protein	protein	NN
cord-001835-0s7ok4uw	2582	10	play	play	VBP
cord-001835-0s7ok4uw	2582	11	a	a	DT
cord-001835-0s7ok4uw	2582	12	vital	vital	JJ
cord-001835-0s7ok4uw	2582	13	role	role	NN
cord-001835-0s7ok4uw	2582	14	in	in	IN
cord-001835-0s7ok4uw	2582	15	the	the	DT
cord-001835-0s7ok4uw	2582	16	redox	redox	JJ
cord-001835-0s7ok4uw	2582	17	activity	activity	NN
cord-001835-0s7ok4uw	2582	18	of	of	IN
cord-001835-0s7ok4uw	2582	19	thioredoxin	thioredoxin	NN
cord-001835-0s7ok4uw	2582	20	.	.	.
cord-001835-0s7ok4uw	2583	1	The	the	DT
cord-001835-0s7ok4uw	2583	2	degree	degree	NN
cord-001835-0s7ok4uw	2583	3	of	of	IN
cord-001835-0s7ok4uw	2583	4	mutational	mutational	JJ
cord-001835-0s7ok4uw	2583	5	frustration	frustration	NN
cord-001835-0s7ok4uw	2583	6	explains	explain	VBZ
cord-001835-0s7ok4uw	2583	7	in	in	IN
cord-001835-0s7ok4uw	2583	8	a	a	DT
cord-001835-0s7ok4uw	2583	9	great	great	JJ
cord-001835-0s7ok4uw	2583	10	deal	deal	NN
cord-001835-0s7ok4uw	2583	11	the	the	DT
cord-001835-0s7ok4uw	2583	12	multiple	multiple	JJ
cord-001835-0s7ok4uw	2583	13	timescales	timescale	NNS
cord-001835-0s7ok4uw	2583	14	observed	observe	VBN
cord-001835-0s7ok4uw	2583	15	in	in	IN
cord-001835-0s7ok4uw	2583	16	the	the	DT
cord-001835-0s7ok4uw	2583	17	protein	protein	NN
cord-001835-0s7ok4uw	2583	18	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2583	19	in	in	IN
cord-001835-0s7ok4uw	2583	20	yTrx1	yTrx1	NNP
cord-001835-0s7ok4uw	2583	21	and	and	CC
cord-001835-0s7ok4uw	2583	22	the	the	DT
cord-001835-0s7ok4uw	2583	23	mutant	mutant	JJ
cord-001835-0s7ok4uw	2583	24	D24A.	d24a.	CD
cord-001835-0s7ok4uw	2584	1	The	the	DT
cord-001835-0s7ok4uw	2584	2	yTrx1	yTrx1	NNP
cord-001835-0s7ok4uw	2584	3	displays	display	VBZ
cord-001835-0s7ok4uw	2584	4	a	a	DT
cord-001835-0s7ok4uw	2584	5	complex	complex	JJ
cord-001835-0s7ok4uw	2584	6	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	2584	7	between	between	IN
cord-001835-0s7ok4uw	2584	8	the	the	DT
cord-001835-0s7ok4uw	2584	9	ground	ground	NN
cord-001835-0s7ok4uw	2584	10	state	state	NN
cord-001835-0s7ok4uw	2584	11	and	and	CC
cord-001835-0s7ok4uw	2584	12	several	several	JJ
cord-001835-0s7ok4uw	2584	13	excited	excited	JJ
cord-001835-0s7ok4uw	2584	14	hydration	hydration	NN
cord-001835-0s7ok4uw	2584	15	states	state	NNS
cord-001835-0s7ok4uw	2584	16	.	.	.
cord-001835-0s7ok4uw	2585	1	This	this	DT
cord-001835-0s7ok4uw	2585	2	excited	excited	JJ
cord-001835-0s7ok4uw	2585	3	states	state	NNS
cord-001835-0s7ok4uw	2585	4	are	be	VBP
cord-001835-0s7ok4uw	2585	5	more	more	RBR
cord-001835-0s7ok4uw	2585	6	permeable	permeable	JJ
cord-001835-0s7ok4uw	2585	7	to	to	IN
cord-001835-0s7ok4uw	2585	8	water	water	NN
cord-001835-0s7ok4uw	2585	9	and	and	CC
cord-001835-0s7ok4uw	2585	10	it	-PRON-	PRP
cord-001835-0s7ok4uw	2585	11	is	be	VBZ
cord-001835-0s7ok4uw	2585	12	key	key	JJ
cord-001835-0s7ok4uw	2585	13	to	to	TO
cord-001835-0s7ok4uw	2585	14	understand	understand	VB
cord-001835-0s7ok4uw	2585	15	the	the	DT
cord-001835-0s7ok4uw	2585	16	proton	proton	NN
cord-001835-0s7ok4uw	2585	17	transfer	transfer	NN
cord-001835-0s7ok4uw	2585	18	and	and	CC
cord-001835-0s7ok4uw	2585	19	activation	activation	NN
cord-001835-0s7ok4uw	2585	20	of	of	IN
cord-001835-0s7ok4uw	2585	21	Cys33	Cys33	NNP
cord-001835-0s7ok4uw	2585	22	.	.	.
cord-001835-0s7ok4uw	2586	1	In	in	IN
cord-001835-0s7ok4uw	2586	2	this	this	DT
cord-001835-0s7ok4uw	2586	3	current	current	JJ
cord-001835-0s7ok4uw	2586	4	study	study	NN
cord-001835-0s7ok4uw	2586	5	,	,	,
cord-001835-0s7ok4uw	2586	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	2586	7	examined	examine	VBD
cord-001835-0s7ok4uw	2586	8	the	the	DT
cord-001835-0s7ok4uw	2586	9	mutant	mutant	JJ
cord-001835-0s7ok4uw	2586	10	D24A	d24a	NN
cord-001835-0s7ok4uw	2586	11	,	,	,
cord-001835-0s7ok4uw	2586	12	and	and	CC
cord-001835-0s7ok4uw	2586	13	observed	observe	VBD
cord-001835-0s7ok4uw	2586	14	that	that	IN
cord-001835-0s7ok4uw	2586	15	this	this	DT
cord-001835-0s7ok4uw	2586	16	small	small	JJ
cord-001835-0s7ok4uw	2586	17	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	2586	18	residue	residue	NN
cord-001835-0s7ok4uw	2586	19	induces	induce	VBZ
cord-001835-0s7ok4uw	2586	20	conformational	conformational	JJ
cord-001835-0s7ok4uw	2586	21	exchange	exchange	NN
cord-001835-0s7ok4uw	2586	22	in	in	IN
cord-001835-0s7ok4uw	2586	23	residues	residue	NNS
cord-001835-0s7ok4uw	2586	24	exposed	expose	VBN
cord-001835-0s7ok4uw	2586	25	to	to	IN
cord-001835-0s7ok4uw	2586	26	the	the	DT
cord-001835-0s7ok4uw	2586	27	water	water	NN
cord-001835-0s7ok4uw	2586	28	cavity	cavity	NN
cord-001835-0s7ok4uw	2586	29	,	,	,
cord-001835-0s7ok4uw	2586	30	such	such	JJ
cord-001835-0s7ok4uw	2586	31	as	as	IN
cord-001835-0s7ok4uw	2586	32	Cys33	Cys33	NNP
cord-001835-0s7ok4uw	2586	33	.	.	.
cord-001835-0s7ok4uw	2587	1	Along	along	IN
cord-001835-0s7ok4uw	2587	2	with	with	IN
cord-001835-0s7ok4uw	2587	3	molecular	molecular	JJ
cord-001835-0s7ok4uw	2587	4	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2587	5	simulations	simulation	NNS
cord-001835-0s7ok4uw	2587	6	and	and	CC
cord-001835-0s7ok4uw	2587	7	calculation	calculation	NN
cord-001835-0s7ok4uw	2587	8	of	of	IN
cord-001835-0s7ok4uw	2587	9	mutational	mutational	JJ
cord-001835-0s7ok4uw	2587	10	frustration	frustration	NN
cord-001835-0s7ok4uw	2587	11	levels	level	NNS
cord-001835-0s7ok4uw	2587	12	,	,	,
cord-001835-0s7ok4uw	2587	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	2587	14	were	be	VBD
cord-001835-0s7ok4uw	2587	15	able	able	JJ
cord-001835-0s7ok4uw	2587	16	to	to	TO
cord-001835-0s7ok4uw	2587	17	describe	describe	VB
cord-001835-0s7ok4uw	2587	18	conformational	conformational	JJ
cord-001835-0s7ok4uw	2587	19	details	detail	NNS
cord-001835-0s7ok4uw	2587	20	of	of	IN
cord-001835-0s7ok4uw	2587	21	the	the	DT
cord-001835-0s7ok4uw	2587	22	water	water	NN
cord-001835-0s7ok4uw	2587	23	cavity	cavity	NN
cord-001835-0s7ok4uw	2587	24	.	.	.
cord-001835-0s7ok4uw	2588	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2588	2	is	be	VBZ
cord-001835-0s7ok4uw	2588	3	formed	form	VBN
cord-001835-0s7ok4uw	2588	4	by	by	IN
cord-001835-0s7ok4uw	2588	5	three	three	CD
cord-001835-0s7ok4uw	2588	6	independent	independent	JJ
cord-001835-0s7ok4uw	2588	7	contiguous	contiguous	JJ
cord-001835-0s7ok4uw	2588	8	lobes	lobe	NNS
cord-001835-0s7ok4uw	2588	9	which	which	WDT
cord-001835-0s7ok4uw	2588	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	2588	11	called	call	VBD
cord-001835-0s7ok4uw	2588	12	lobes	lobe	NNS
cord-001835-0s7ok4uw	2588	13	A	A	NNP
cord-001835-0s7ok4uw	2588	14	,	,	,
cord-001835-0s7ok4uw	2588	15	B	B	NNP
cord-001835-0s7ok4uw	2588	16	and	and	CC
cord-001835-0s7ok4uw	2588	17	C.	C.	NNP
cord-001835-0s7ok4uw	2588	18	Lobe	Lobe	NNP
cord-001835-0s7ok4uw	2588	19	B	B	NNP
cord-001835-0s7ok4uw	2589	1	is	be	VBZ
cord-001835-0s7ok4uw	2589	2	the	the	DT
cord-001835-0s7ok4uw	2589	3	central	central	JJ
cord-001835-0s7ok4uw	2589	4	lobe	lobe	NN
cord-001835-0s7ok4uw	2589	5	that	that	WDT
cord-001835-0s7ok4uw	2589	6	contains	contain	VBZ
cord-001835-0s7ok4uw	2589	7	the	the	DT
cord-001835-0s7ok4uw	2589	8	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2589	9	important	important	JJ
cord-001835-0s7ok4uw	2589	10	residues	residue	NNS
cord-001835-0s7ok4uw	2589	11	Cys33	Cys33	NNP
cord-001835-0s7ok4uw	2589	12	and	and	CC
cord-001835-0s7ok4uw	2589	13	Asp24	Asp24	NNP
cord-001835-0s7ok4uw	2589	14	.	.	.
cord-001835-0s7ok4uw	2590	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2590	2	closed	close	VBD
cord-001835-0s7ok4uw	2590	3	upon	upon	IN
cord-001835-0s7ok4uw	2590	4	mutation	mutation	NN
cord-001835-0s7ok4uw	2590	5	D24A.	d24a.	CD
cord-001835-0s7ok4uw	2591	1	Lobe	Lobe	NNP
cord-001835-0s7ok4uw	2591	2	A	A	NNP
cord-001835-0s7ok4uw	2591	3	and	and	CC
cord-001835-0s7ok4uw	2591	4	C	C	NNP
cord-001835-0s7ok4uw	2591	5	remains	remain	VBZ
cord-001835-0s7ok4uw	2591	6	open	open	JJ
cord-001835-0s7ok4uw	2591	7	upon	upon	IN
cord-001835-0s7ok4uw	2591	8	mutation	mutation	NN
cord-001835-0s7ok4uw	2591	9	,	,	,
cord-001835-0s7ok4uw	2591	10	meaning	mean	VBG
cord-001835-0s7ok4uw	2591	11	that	that	IN
cord-001835-0s7ok4uw	2591	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2591	13	hydration	hydration	NN
cord-001835-0s7ok4uw	2591	14	are	be	VBP
cord-001835-0s7ok4uw	2591	15	independent	independent	JJ
cord-001835-0s7ok4uw	2591	16	.	.	.
cord-001835-0s7ok4uw	2592	1	The	the	DT
cord-001835-0s7ok4uw	2592	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	2592	3	structures	structure	NNS
cord-001835-0s7ok4uw	2592	4	for	for	IN
cord-001835-0s7ok4uw	2592	5	the	the	DT
cord-001835-0s7ok4uw	2592	6	oxidized	oxidize	VBN
cord-001835-0s7ok4uw	2592	7	and	and	CC
cord-001835-0s7ok4uw	2592	8	reduced	reduce	VBN
cord-001835-0s7ok4uw	2592	9	state	state	NN
cord-001835-0s7ok4uw	2592	10	of	of	IN
cord-001835-0s7ok4uw	2592	11	the	the	DT
cord-001835-0s7ok4uw	2592	12	Mutant	mutant	JJ
cord-001835-0s7ok4uw	2592	13	D24A	D24A	NNP
cord-001835-0s7ok4uw	2592	14	has	have	VBZ
cord-001835-0s7ok4uw	2592	15	been	be	VBN
cord-001835-0s7ok4uw	2592	16	studied	study	VBN
cord-001835-0s7ok4uw	2592	17	.	.	.
cord-001835-0s7ok4uw	2593	1	In	in	IN
cord-001835-0s7ok4uw	2593	2	-	-	HYPH
cord-001835-0s7ok4uw	2593	3	vitro	vitro	FW
cord-001835-0s7ok4uw	2593	4	and	and	CC
cord-001835-0s7ok4uw	2593	5	in	in	IN
cord-001835-0s7ok4uw	2593	6	-	-	HYPH
cord-001835-0s7ok4uw	2593	7	silico	silico	JJ
cord-001835-0s7ok4uw	2593	8	studies	study	NNS
cord-001835-0s7ok4uw	2593	9	of	of	IN
cord-001835-0s7ok4uw	2593	10	ligand	ligand	NN
cord-001835-0s7ok4uw	2593	11	binding	bind	VBG
cord-001835-0s7ok4uw	2593	12	to	to	IN
cord-001835-0s7ok4uw	2593	13	the	the	DT
cord-001835-0s7ok4uw	2593	14	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	2593	15	receptor	receptor	NN
cord-001835-0s7ok4uw	2593	16	PPARgamma	PPARgamma	NNP
cord-001835-0s7ok4uw	2593	17	using	use	VBG
cord-001835-0s7ok4uw	2593	18	FRET	FRET	NNP
cord-001835-0s7ok4uw	2593	19	and	and	CC
cord-001835-0s7ok4uw	2593	20	MD	MD	NNP
cord-001835-0s7ok4uw	2593	21	Narutoshi	Narutoshi	NNP
cord-001835-0s7ok4uw	2593	22	Kamiya	Kamiya	NNP
cord-001835-0s7ok4uw	2593	23	1	1	CD
cord-001835-0s7ok4uw	2593	24	,	,	,
cord-001835-0s7ok4uw	2593	25	Gert	Gert	NNP
cord-001835-0s7ok4uw	2593	26	-	-	HYPH
cord-001835-0s7ok4uw	2593	27	Jan	Jan	NNP
cord-001835-0s7ok4uw	2593	28	Bekker	Bekker	NNP
cord-001835-0s7ok4uw	2593	29	1	1	CD
cord-001835-0s7ok4uw	2593	30	,	,	,
cord-001835-0s7ok4uw	2593	31	Takuma	Takuma	NNP
cord-001835-0s7ok4uw	2593	32	Shiraki	Shiraki	NNP
cord-001835-0s7ok4uw	2593	33	2	2	CD
cord-001835-0s7ok4uw	2593	34	,	,	,
cord-001835-0s7ok4uw	2593	35	Haruki	Haruki	NNP
cord-001835-0s7ok4uw	2593	36	Nakamura	Nakamura	NNP
cord-001835-0s7ok4uw	2594	1	1	1	CD
cord-001835-0s7ok4uw	2594	2	1	1	CD
cord-001835-0s7ok4uw	2594	3	IPR	IPR	NNP
cord-001835-0s7ok4uw	2594	4	,	,	,
cord-001835-0s7ok4uw	2594	5	Osaka	Osaka	NNP
cord-001835-0s7ok4uw	2594	6	University	University	NNP
cord-001835-0s7ok4uw	2594	7	,	,	,
cord-001835-0s7ok4uw	2594	8	2	2	CD
cord-001835-0s7ok4uw	2594	9	Kinki	Kinki	NNP
cord-001835-0s7ok4uw	2594	10	University	University	NNP
cord-001835-0s7ok4uw	2595	1	The	the	DT
cord-001835-0s7ok4uw	2595	2	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	2595	3	receptor	receptor	NN
cord-001835-0s7ok4uw	2595	4	PPARgamma	PPARgamma	NNP
cord-001835-0s7ok4uw	2595	5	is	be	VBZ
cord-001835-0s7ok4uw	2595	6	a	a	DT
cord-001835-0s7ok4uw	2595	7	ligand	ligand	NN
cord-001835-0s7ok4uw	2595	8	-	-	HYPH
cord-001835-0s7ok4uw	2595	9	dependent	dependent	JJ
cord-001835-0s7ok4uw	2595	10	transcription	transcription	NN
cord-001835-0s7ok4uw	2595	11	factor	factor	NN
cord-001835-0s7ok4uw	2595	12	which	which	WDT
cord-001835-0s7ok4uw	2595	13	regulates	regulate	VBZ
cord-001835-0s7ok4uw	2595	14	gene	gene	NN
cord-001835-0s7ok4uw	2595	15	expression	expression	NN
cord-001835-0s7ok4uw	2595	16	related	relate	VBN
cord-001835-0s7ok4uw	2595	17	to	to	IN
cord-001835-0s7ok4uw	2595	18	glucose	glucose	NN
cord-001835-0s7ok4uw	2595	19	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	2595	20	and	and	CC
cord-001835-0s7ok4uw	2595	21	insulin	insulin	NN
cord-001835-0s7ok4uw	2595	22	sensitization	sensitization	NN
cord-001835-0s7ok4uw	2595	23	.	.	.
cord-001835-0s7ok4uw	2596	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2596	2	is	be	VBZ
cord-001835-0s7ok4uw	2596	3	a	a	DT
cord-001835-0s7ok4uw	2596	4	potential	potential	JJ
cord-001835-0s7ok4uw	2596	5	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	2596	6	target	target	NN
cord-001835-0s7ok4uw	2596	7	for	for	IN
cord-001835-0s7ok4uw	2596	8	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	2596	9	syndrome	syndrome	NN
cord-001835-0s7ok4uw	2596	10	,	,	,
cord-001835-0s7ok4uw	2596	11	cancer	cancer	NN
cord-001835-0s7ok4uw	2596	12	,	,	,
cord-001835-0s7ok4uw	2596	13	and	and	CC
cord-001835-0s7ok4uw	2596	14	inflammatory	inflammatory	JJ
cord-001835-0s7ok4uw	2596	15	diseases	disease	NNS
cord-001835-0s7ok4uw	2596	16	.	.	.
cord-001835-0s7ok4uw	2597	1	Crystal	crystal	NN
cord-001835-0s7ok4uw	2597	2	structures	structure	NNS
cord-001835-0s7ok4uw	2597	3	have	have	VBP
cord-001835-0s7ok4uw	2597	4	revealed	reveal	VBN
cord-001835-0s7ok4uw	2597	5	that	that	IN
cord-001835-0s7ok4uw	2597	6	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2597	7	ligands	ligand	NNS
cord-001835-0s7ok4uw	2597	8	bind	bind	VBP
cord-001835-0s7ok4uw	2597	9	deep	deep	RB
cord-001835-0s7ok4uw	2597	10	inside	inside	IN
cord-001835-0s7ok4uw	2597	11	the	the	DT
cord-001835-0s7ok4uw	2597	12	pocket	pocket	NN
cord-001835-0s7ok4uw	2597	13	.	.	.
cord-001835-0s7ok4uw	2598	1	However	however	RB
cord-001835-0s7ok4uw	2598	2	,	,	,
cord-001835-0s7ok4uw	2598	3	how	how	WRB
cord-001835-0s7ok4uw	2598	4	the	the	DT
cord-001835-0s7ok4uw	2598	5	ligand	ligand	NN
cord-001835-0s7ok4uw	2598	6	recognizes	recognize	VBZ
cord-001835-0s7ok4uw	2598	7	PPARgamma	PPARgamma	NNP
cord-001835-0s7ok4uw	2598	8	and	and	CC
cord-001835-0s7ok4uw	2598	9	penetrates	penetrate	VBZ
cord-001835-0s7ok4uw	2598	10	inside	inside	IN
cord-001835-0s7ok4uw	2598	11	the	the	DT
cord-001835-0s7ok4uw	2598	12	pocket	pocket	NN
cord-001835-0s7ok4uw	2598	13	remains	remain	VBZ
cord-001835-0s7ok4uw	2598	14	unclear	unclear	JJ
cord-001835-0s7ok4uw	2598	15	.	.	.
cord-001835-0s7ok4uw	2599	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2599	2	have	have	VBP
cord-001835-0s7ok4uw	2599	3	measured	measure	VBN
cord-001835-0s7ok4uw	2599	4	the	the	DT
cord-001835-0s7ok4uw	2599	5	binding	bind	VBG
cord-001835-0s7ok4uw	2599	6	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2599	7	using	use	VBG
cord-001835-0s7ok4uw	2599	8	the	the	DT
cord-001835-0s7ok4uw	2599	9	FRET	fret	NN
cord-001835-0s7ok4uw	2599	10	method	method	NN
cord-001835-0s7ok4uw	2599	11	and	and	CC
cord-001835-0s7ok4uw	2599	12	have	have	VBP
cord-001835-0s7ok4uw	2599	13	calculated	calculate	VBN
cord-001835-0s7ok4uw	2599	14	potential	potential	JJ
cord-001835-0s7ok4uw	2599	15	dissociation	dissociation	NN
cord-001835-0s7ok4uw	2599	16	paths	path	NNS
cord-001835-0s7ok4uw	2599	17	via	via	IN
cord-001835-0s7ok4uw	2599	18	molecular	molecular	JJ
cord-001835-0s7ok4uw	2599	19	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2599	20	(	(	-LRB-
cord-001835-0s7ok4uw	2599	21	MD	MD	NNP
cord-001835-0s7ok4uw	2599	22	)	)	-RRB-
cord-001835-0s7ok4uw	2599	23	simulations	simulation	NNS
cord-001835-0s7ok4uw	2599	24	.	.	.
cord-001835-0s7ok4uw	2600	1	The	the	DT
cord-001835-0s7ok4uw	2600	2	binding	bind	VBG
cord-001835-0s7ok4uw	2600	3	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2600	4	were	be	VBD
cord-001835-0s7ok4uw	2600	5	measured	measure	VBN
cord-001835-0s7ok4uw	2600	6	using	use	VBG
cord-001835-0s7ok4uw	2600	7	FRET	fret	NN
cord-001835-0s7ok4uw	2600	8	between	between	IN
cord-001835-0s7ok4uw	2600	9	the	the	DT
cord-001835-0s7ok4uw	2600	10	ligand	ligand	NN
cord-001835-0s7ok4uw	2600	11	,	,	,
cord-001835-0s7ok4uw	2600	12	C8-BODIPY	C8-BODIPY	NNP
cord-001835-0s7ok4uw	2600	13	,	,	,
cord-001835-0s7ok4uw	2600	14	which	which	WDT
cord-001835-0s7ok4uw	2600	15	is	be	VBZ
cord-001835-0s7ok4uw	2600	16	a	a	DT
cord-001835-0s7ok4uw	2600	17	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	2600	18	pigment	pigment	NN
cord-001835-0s7ok4uw	2600	19	structurally	structurally	RB
cord-001835-0s7ok4uw	2600	20	similar	similar	JJ
cord-001835-0s7ok4uw	2600	21	to	to	IN
cord-001835-0s7ok4uw	2600	22	one	one	CD
cord-001835-0s7ok4uw	2600	23	of	of	IN
cord-001835-0s7ok4uw	2600	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2600	25	agonists	agonist	NNS
cord-001835-0s7ok4uw	2600	26	15-oxo	15-oxo	CD
cord-001835-0s7ok4uw	2600	27	-	-	HYPH
cord-001835-0s7ok4uw	2600	28	eicosatetraenoic	eicosatetraenoic	NNP
cord-001835-0s7ok4uw	2600	29	acid	acid	NN
cord-001835-0s7ok4uw	2600	30	,	,	,
cord-001835-0s7ok4uw	2600	31	and	and	CC
cord-001835-0s7ok4uw	2600	32	cyan	cyan	NN
cord-001835-0s7ok4uw	2600	33	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	2600	34	protein	protein	NN
cord-001835-0s7ok4uw	2600	35	(	(	-LRB-
cord-001835-0s7ok4uw	2600	36	CFP	CFP	NNP
cord-001835-0s7ok4uw	2600	37	)	)	-RRB-
cord-001835-0s7ok4uw	2600	38	which	which	WDT
cord-001835-0s7ok4uw	2600	39	is	be	VBZ
cord-001835-0s7ok4uw	2600	40	fused	fuse	VBN
cord-001835-0s7ok4uw	2600	41	to	to	IN
cord-001835-0s7ok4uw	2600	42	PPARgamma	PPARgamma	NNP
cord-001835-0s7ok4uw	2600	43	.	.	.
cord-001835-0s7ok4uw	2601	1	Fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2601	2	of	of	IN
cord-001835-0s7ok4uw	2601	3	C8-BODIPY	C8-BODIPY	NNP
cord-001835-0s7ok4uw	2601	4	is	be	VBZ
cord-001835-0s7ok4uw	2601	5	observed	observe	VBN
cord-001835-0s7ok4uw	2601	6	when	when	WRB
cord-001835-0s7ok4uw	2601	7	it	-PRON-	PRP
cord-001835-0s7ok4uw	2601	8	is	be	VBZ
cord-001835-0s7ok4uw	2601	9	close	close	JJ
cord-001835-0s7ok4uw	2601	10	to	to	IN
cord-001835-0s7ok4uw	2601	11	CFP	CFP	NNP
cord-001835-0s7ok4uw	2601	12	when	when	WRB
cord-001835-0s7ok4uw	2601	13	CFP	CFP	NNP
cord-001835-0s7ok4uw	2601	14	is	be	VBZ
cord-001835-0s7ok4uw	2601	15	excited	excite	VBN
cord-001835-0s7ok4uw	2601	16	by	by	IN
cord-001835-0s7ok4uw	2601	17	light	light	NN
cord-001835-0s7ok4uw	2601	18	at	at	IN
cord-001835-0s7ok4uw	2601	19	410	410	CD
cord-001835-0s7ok4uw	2601	20	nm	nm	NN
cord-001835-0s7ok4uw	2601	21	.	.	.
cord-001835-0s7ok4uw	2602	1	The	the	DT
cord-001835-0s7ok4uw	2602	2	ligand	ligand	NN
cord-001835-0s7ok4uw	2602	3	was	be	VBD
cord-001835-0s7ok4uw	2602	4	simultaneously	simultaneously	RB
cord-001835-0s7ok4uw	2602	5	added	add	VBN
cord-001835-0s7ok4uw	2602	6	to	to	IN
cord-001835-0s7ok4uw	2602	7	the	the	DT
cord-001835-0s7ok4uw	2602	8	PPARgamma	PPARgamma	NNP
cord-001835-0s7ok4uw	2602	9	-	-	HYPH
cord-001835-0s7ok4uw	2602	10	CFP	CFP	NNP
cord-001835-0s7ok4uw	2602	11	solution	solution	NN
cord-001835-0s7ok4uw	2602	12	using	use	VBG
cord-001835-0s7ok4uw	2602	13	the	the	DT
cord-001835-0s7ok4uw	2602	14	stopped	stop	VBN
cord-001835-0s7ok4uw	2602	15	-	-	HYPH
cord-001835-0s7ok4uw	2602	16	flow	flow	NN
cord-001835-0s7ok4uw	2602	17	method	method	NN
cord-001835-0s7ok4uw	2602	18	.	.	.
cord-001835-0s7ok4uw	2603	1	Time	time	NN
cord-001835-0s7ok4uw	2603	2	-	-	HYPH
cord-001835-0s7ok4uw	2603	3	resolved	resolve	VBN
cord-001835-0s7ok4uw	2603	4	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2603	5	signals	signal	NNS
cord-001835-0s7ok4uw	2603	6	of	of	IN
cord-001835-0s7ok4uw	2603	7	C8-BODIPY	C8-BODIPY	NNP
cord-001835-0s7ok4uw	2604	1	and	and	CC
cord-001835-0s7ok4uw	2604	2	CFP	CFP	NNP
cord-001835-0s7ok4uw	2604	3	were	be	VBD
cord-001835-0s7ok4uw	2604	4	also	also	RB
cord-001835-0s7ok4uw	2604	5	monitored	monitor	VBN
cord-001835-0s7ok4uw	2604	6	.	.	.
cord-001835-0s7ok4uw	2605	1	Two	two	CD
cord-001835-0s7ok4uw	2605	2	time	time	NN
cord-001835-0s7ok4uw	2605	3	constants	constant	NNS
cord-001835-0s7ok4uw	2605	4	were	be	VBD
cord-001835-0s7ok4uw	2605	5	observed	observe	VBN
cord-001835-0s7ok4uw	2605	6	by	by	IN
cord-001835-0s7ok4uw	2605	7	the	the	DT
cord-001835-0s7ok4uw	2605	8	FRET	FRET	NNP
cord-001835-0s7ok4uw	2605	9	experiment	experiment	NN
cord-001835-0s7ok4uw	2605	10	,	,	,
cord-001835-0s7ok4uw	2605	11	which	which	WDT
cord-001835-0s7ok4uw	2605	12	correspond	correspond	VBP
cord-001835-0s7ok4uw	2605	13	with	with	IN
cord-001835-0s7ok4uw	2605	14	the	the	DT
cord-001835-0s7ok4uw	2605	15	landing	landing	NN
cord-001835-0s7ok4uw	2605	16	and	and	CC
cord-001835-0s7ok4uw	2605	17	docking	docking	NN
cord-001835-0s7ok4uw	2605	18	processes	process	NNS
cord-001835-0s7ok4uw	2605	19	.	.	.
cord-001835-0s7ok4uw	2606	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2606	2	used	use	VBD
cord-001835-0s7ok4uw	2606	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2606	4	new	new	JJ
cord-001835-0s7ok4uw	2606	5	MD	MD	NNP
cord-001835-0s7ok4uw	2606	6	program	program	NN
cord-001835-0s7ok4uw	2606	7	,	,	,
cord-001835-0s7ok4uw	2606	8	psygene	psygene	NN
cord-001835-0s7ok4uw	2606	9	-	-	HYPH
cord-001835-0s7ok4uw	2606	10	G	g	NN
cord-001835-0s7ok4uw	2606	11	[	[	-LRB-
cord-001835-0s7ok4uw	2606	12	1	1	CD
cord-001835-0s7ok4uw	2606	13	]	]	-RRB-
cord-001835-0s7ok4uw	2606	14	,	,	,
cord-001835-0s7ok4uw	2606	15	which	which	WDT
cord-001835-0s7ok4uw	2606	16	utilizes	utilize	VBZ
cord-001835-0s7ok4uw	2606	17	the	the	DT
cord-001835-0s7ok4uw	2606	18	GPU	GPU	NNP
cord-001835-0s7ok4uw	2606	19	for	for	IN
cord-001835-0s7ok4uw	2606	20	acceleration	acceleration	NN
cord-001835-0s7ok4uw	2606	21	of	of	IN
cord-001835-0s7ok4uw	2606	22	the	the	DT
cord-001835-0s7ok4uw	2606	23	non	non	JJ
cord-001835-0s7ok4uw	2606	24	-	-	JJ
cord-001835-0s7ok4uw	2606	25	bonded	bond	VBN
cord-001835-0s7ok4uw	2606	26	interactions	interaction	NNS
cord-001835-0s7ok4uw	2606	27	,	,	,
cord-001835-0s7ok4uw	2606	28	such	such	JJ
cord-001835-0s7ok4uw	2606	29	as	as	IN
cord-001835-0s7ok4uw	2606	30	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	2606	31	interaction	interaction	NN
cord-001835-0s7ok4uw	2606	32	which	which	WDT
cord-001835-0s7ok4uw	2606	33	uses	use	VBZ
cord-001835-0s7ok4uw	2606	34	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2606	35	original	original	JJ
cord-001835-0s7ok4uw	2606	36	zero	zero	CD
cord-001835-0s7ok4uw	2606	37	-	-	HYPH
cord-001835-0s7ok4uw	2606	38	dipole	dipole	NN
cord-001835-0s7ok4uw	2606	39	summation	summation	JJ
cord-001835-0s7ok4uw	2606	40	method	method	NN
cord-001835-0s7ok4uw	2606	41	[	[	-LRB-
cord-001835-0s7ok4uw	2606	42	2	2	CD
cord-001835-0s7ok4uw	2606	43	,	,	,
cord-001835-0s7ok4uw	2606	44	3	3	CD
cord-001835-0s7ok4uw	2606	45	]	]	-RRB-
cord-001835-0s7ok4uw	2606	46	.	.	.
cord-001835-0s7ok4uw	2607	1	Previously	previously	RB
cord-001835-0s7ok4uw	2607	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2607	3	were	be	VBD
cord-001835-0s7ok4uw	2607	4	able	able	JJ
cord-001835-0s7ok4uw	2607	5	to	to	TO
cord-001835-0s7ok4uw	2607	6	attain	attain	VB
cord-001835-0s7ok4uw	2607	7	similar	similar	JJ
cord-001835-0s7ok4uw	2607	8	thermodynamics	thermodynamic	NNS
cord-001835-0s7ok4uw	2607	9	with	with	IN
cord-001835-0s7ok4uw	2607	10	respect	respect	NN
cord-001835-0s7ok4uw	2607	11	to	to	IN
cord-001835-0s7ok4uw	2607	12	the	the	DT
cord-001835-0s7ok4uw	2607	13	particle	particle	NN
cord-001835-0s7ok4uw	2607	14	mesh	mesh	NN
cord-001835-0s7ok4uw	2607	15	Ewald	Ewald	NNP
cord-001835-0s7ok4uw	2607	16	method	method	NN
cord-001835-0s7ok4uw	2607	17	in	in	IN
cord-001835-0s7ok4uw	2607	18	membrane	membrane	NN
cord-001835-0s7ok4uw	2607	19	proteins	protein	NNS
cord-001835-0s7ok4uw	2607	20	and	and	CC
cord-001835-0s7ok4uw	2607	21	DNA	dna	NN
cord-001835-0s7ok4uw	2607	22	-	-	HYPH
cord-001835-0s7ok4uw	2607	23	water	water	NN
cord-001835-0s7ok4uw	2607	24	-	-	HYPH
cord-001835-0s7ok4uw	2607	25	ion	ion	NN
cord-001835-0s7ok4uw	2607	26	systems	system	NNS
cord-001835-0s7ok4uw	2607	27	[	[	-LRB-
cord-001835-0s7ok4uw	2607	28	4	4	CD
cord-001835-0s7ok4uw	2607	29	,	,	,
cord-001835-0s7ok4uw	2607	30	5	5	CD
cord-001835-0s7ok4uw	2607	31	]	]	-RRB-
cord-001835-0s7ok4uw	2607	32	and	and	CC
cord-001835-0s7ok4uw	2607	33	have	have	VBP
cord-001835-0s7ok4uw	2607	34	applied	apply	VBN
cord-001835-0s7ok4uw	2607	35	it	-PRON-	PRP
cord-001835-0s7ok4uw	2607	36	to	to	IN
cord-001835-0s7ok4uw	2607	37	the	the	DT
cord-001835-0s7ok4uw	2607	38	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	2607	39	study	study	NN
cord-001835-0s7ok4uw	2607	40	of	of	IN
cord-001835-0s7ok4uw	2607	41	dynein	dynein	NNP
cord-001835-0s7ok4uw	2607	42	[	[	-LRB-
cord-001835-0s7ok4uw	2607	43	6	6	CD
cord-001835-0s7ok4uw	2607	44	]	]	-RRB-
cord-001835-0s7ok4uw	2607	45	.	.	.
cord-001835-0s7ok4uw	2608	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2608	2	have	have	VBP
cord-001835-0s7ok4uw	2608	3	introduced	introduce	VBN
cord-001835-0s7ok4uw	2608	4	random	random	JJ
cord-001835-0s7ok4uw	2608	5	accelerated	accelerate	VBN
cord-001835-0s7ok4uw	2608	6	MD	MD	NNP
cord-001835-0s7ok4uw	2608	7	(	(	-LRB-
cord-001835-0s7ok4uw	2608	8	RAMD	RAMD	NNP
cord-001835-0s7ok4uw	2608	9	)	)	-RRB-
cord-001835-0s7ok4uw	2608	10	into	into	IN
cord-001835-0s7ok4uw	2608	11	the	the	DT
cord-001835-0s7ok4uw	2608	12	psygene	psygene	JJ
cord-001835-0s7ok4uw	2608	13	-	-	HYPH
cord-001835-0s7ok4uw	2608	14	G	g	NN
cord-001835-0s7ok4uw	2608	15	program	program	NN
cord-001835-0s7ok4uw	2608	16	to	to	TO
cord-001835-0s7ok4uw	2608	17	predict	predict	VB
cord-001835-0s7ok4uw	2608	18	a	a	DT
cord-001835-0s7ok4uw	2608	19	ligand	ligand	NN
cord-001835-0s7ok4uw	2608	20	's	's	POS
cord-001835-0s7ok4uw	2608	21	dissociation	dissociation	NN
cord-001835-0s7ok4uw	2608	22	path	path	NN
cord-001835-0s7ok4uw	2608	23	from	from	IN
cord-001835-0s7ok4uw	2608	24	the	the	DT
cord-001835-0s7ok4uw	2608	25	initial	initial	JJ
cord-001835-0s7ok4uw	2608	26	crystal	crystal	NN
cord-001835-0s7ok4uw	2608	27	structure	structure	NN
cord-001835-0s7ok4uw	2608	28	(	(	-LRB-
cord-001835-0s7ok4uw	2608	29	PDB	PDB	NNP
cord-001835-0s7ok4uw	2608	30	ID	ID	NNP
cord-001835-0s7ok4uw	2608	31	:	:	:
cord-001835-0s7ok4uw	2608	32	2zk6	2zk6	CD
cord-001835-0s7ok4uw	2608	33	)	)	-RRB-
cord-001835-0s7ok4uw	2608	34	.	.	.
cord-001835-0s7ok4uw	2609	1	In	in	IN
cord-001835-0s7ok4uw	2609	2	RAMD	RAMD	NNP
cord-001835-0s7ok4uw	2609	3	,	,	,
cord-001835-0s7ok4uw	2609	4	an	an	DT
cord-001835-0s7ok4uw	2609	5	external	external	JJ
cord-001835-0s7ok4uw	2609	6	random	random	JJ
cord-001835-0s7ok4uw	2609	7	-	-	HYPH
cord-001835-0s7ok4uw	2609	8	directional	directional	JJ
cord-001835-0s7ok4uw	2609	9	constant	constant	JJ
cord-001835-0s7ok4uw	2609	10	force	force	NN
cord-001835-0s7ok4uw	2609	11	is	be	VBZ
cord-001835-0s7ok4uw	2609	12	added	add	VBN
cord-001835-0s7ok4uw	2609	13	to	to	IN
cord-001835-0s7ok4uw	2609	14	the	the	DT
cord-001835-0s7ok4uw	2609	15	ligand	ligand	NN
cord-001835-0s7ok4uw	2609	16	.	.	.
cord-001835-0s7ok4uw	2610	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2610	2	executed	execute	VBD
cord-001835-0s7ok4uw	2610	3	96-RAMD	96-ramd	JJ
cord-001835-0s7ok4uw	2610	4	simulations	simulation	NNS
cord-001835-0s7ok4uw	2610	5	with	with	IN
cord-001835-0s7ok4uw	2610	6	different	different	JJ
cord-001835-0s7ok4uw	2610	7	random	random	JJ
cord-001835-0s7ok4uw	2610	8	seeds	seed	NNS
cord-001835-0s7ok4uw	2610	9	for	for	IN
cord-001835-0s7ok4uw	2610	10	the	the	DT
cord-001835-0s7ok4uw	2610	11	initial	initial	JJ
cord-001835-0s7ok4uw	2610	12	pull	pull	NN
cord-001835-0s7ok4uw	2610	13	directions	direction	NNS
cord-001835-0s7ok4uw	2610	14	.	.	.
cord-001835-0s7ok4uw	2611	1	Twelve	twelve	CD
cord-001835-0s7ok4uw	2611	2	RAMD	RAMD	NNP
cord-001835-0s7ok4uw	2611	3	trajectories	trajectory	NNS
cord-001835-0s7ok4uw	2611	4	managed	manage	VBD
cord-001835-0s7ok4uw	2611	5	to	to	TO
cord-001835-0s7ok4uw	2611	6	dissociate	dissociate	VB
cord-001835-0s7ok4uw	2611	7	within	within	IN
cord-001835-0s7ok4uw	2611	8	1	1	CD
cord-001835-0s7ok4uw	2611	9	ns	n	NNS
cord-001835-0s7ok4uw	2611	10	,	,	,
cord-001835-0s7ok4uw	2611	11	while	while	IN
cord-001835-0s7ok4uw	2611	12	the	the	DT
cord-001835-0s7ok4uw	2611	13	remaining	remain	VBG
cord-001835-0s7ok4uw	2611	14	simulations	simulation	NNS
cord-001835-0s7ok4uw	2611	15	did	do	VBD
cord-001835-0s7ok4uw	2611	16	not	not	RB
cord-001835-0s7ok4uw	2611	17	manage	manage	VB
cord-001835-0s7ok4uw	2611	18	to	to	TO
cord-001835-0s7ok4uw	2611	19	disassociate	disassociate	VB
cord-001835-0s7ok4uw	2611	20	within	within	IN
cord-001835-0s7ok4uw	2611	21	this	this	DT
cord-001835-0s7ok4uw	2611	22	time	time	NN
cord-001835-0s7ok4uw	2611	23	-	-	HYPH
cord-001835-0s7ok4uw	2611	24	frame	frame	NN
cord-001835-0s7ok4uw	2611	25	.	.	.
cord-001835-0s7ok4uw	2612	1	In	in	IN
cord-001835-0s7ok4uw	2612	2	all	all	DT
cord-001835-0s7ok4uw	2612	3	twelve	twelve	CD
cord-001835-0s7ok4uw	2612	4	cases	case	NNS
cord-001835-0s7ok4uw	2612	5	the	the	DT
cord-001835-0s7ok4uw	2612	6	ligand	ligand	NN
cord-001835-0s7ok4uw	2612	7	went	go	VBD
cord-001835-0s7ok4uw	2612	8	past	past	JJ
cord-001835-0s7ok4uw	2612	9	R288	R288	NNP
cord-001835-0s7ok4uw	2612	10	,	,	,
cord-001835-0s7ok4uw	2612	11	which	which	WDT
cord-001835-0s7ok4uw	2612	12	is	be	VBZ
cord-001835-0s7ok4uw	2612	13	located	locate	VBN
cord-001835-0s7ok4uw	2612	14	at	at	IN
cord-001835-0s7ok4uw	2612	15	the	the	DT
cord-001835-0s7ok4uw	2612	16	surface	surface	NN
cord-001835-0s7ok4uw	2612	17	of	of	IN
cord-001835-0s7ok4uw	2612	18	PPARgamma	PPARgamma	NNP
cord-001835-0s7ok4uw	2612	19	.	.	.
cord-001835-0s7ok4uw	2613	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	2613	2	,	,	,
cord-001835-0s7ok4uw	2613	3	a	a	DT
cord-001835-0s7ok4uw	2613	4	somatic	somatic	JJ
cord-001835-0s7ok4uw	2613	5	mutant	mutant	NN
cord-001835-0s7ok4uw	2613	6	(	(	-LRB-
cord-001835-0s7ok4uw	2613	7	R288H	r288h	NN
cord-001835-0s7ok4uw	2613	8	)	)	-RRB-
cord-001835-0s7ok4uw	2613	9	is	be	VBZ
cord-001835-0s7ok4uw	2613	10	related	relate	VBN
cord-001835-0s7ok4uw	2613	11	to	to	IN
cord-001835-0s7ok4uw	2613	12	colon	colon	NN
cord-001835-0s7ok4uw	2613	13	cancer	cancer	NN
cord-001835-0s7ok4uw	2613	14	.	.	.
cord-001835-0s7ok4uw	2614	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2614	2	concluded	conclude	VBD
cord-001835-0s7ok4uw	2614	3	that	that	IN
cord-001835-0s7ok4uw	2614	4	R288	R288	NNP
cord-001835-0s7ok4uw	2614	5	plays	play	VBZ
cord-001835-0s7ok4uw	2614	6	a	a	DT
cord-001835-0s7ok4uw	2614	7	role	role	NN
cord-001835-0s7ok4uw	2614	8	of	of	IN
cord-001835-0s7ok4uw	2614	9	a	a	DT
cord-001835-0s7ok4uw	2614	10	gate	gate	NN
cord-001835-0s7ok4uw	2614	11	keeper	keeper	NN
cord-001835-0s7ok4uw	2614	12	to	to	TO
cord-001835-0s7ok4uw	2614	13	assist	assist	VB
cord-001835-0s7ok4uw	2614	14	ligand	ligand	NN
cord-001835-0s7ok4uw	2614	15	binding	binding	NN
cord-001835-0s7ok4uw	2614	16	.	.	.
cord-001835-0s7ok4uw	2614	17	 	 	_SP
cord-001835-0s7ok4uw	2615	1	SUMOylation	sumoylation	NN
cord-001835-0s7ok4uw	2615	2	is	be	VBZ
cord-001835-0s7ok4uw	2615	3	a	a	DT
cord-001835-0s7ok4uw	2615	4	post	post	JJ
cord-001835-0s7ok4uw	2615	5	-	-	JJ
cord-001835-0s7ok4uw	2615	6	translational	translational	JJ
cord-001835-0s7ok4uw	2615	7	modification	modification	NN
cord-001835-0s7ok4uw	2615	8	involved	involve	VBN
cord-001835-0s7ok4uw	2615	9	in	in	IN
cord-001835-0s7ok4uw	2615	10	various	various	JJ
cord-001835-0s7ok4uw	2615	11	cellular	cellular	JJ
cord-001835-0s7ok4uw	2615	12	processes	process	NNS
cord-001835-0s7ok4uw	2615	13	,	,	,
cord-001835-0s7ok4uw	2615	14	such	such	JJ
cord-001835-0s7ok4uw	2615	15	as	as	IN
cord-001835-0s7ok4uw	2615	16	nuclearcytosolic	nuclearcytosolic	NNP
cord-001835-0s7ok4uw	2615	17	transport	transport	NN
cord-001835-0s7ok4uw	2615	18	,	,	,
cord-001835-0s7ok4uw	2615	19	transcriptional	transcriptional	JJ
cord-001835-0s7ok4uw	2615	20	regulation	regulation	NN
cord-001835-0s7ok4uw	2615	21	,	,	,
cord-001835-0s7ok4uw	2615	22	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	2615	23	,	,	,
cord-001835-0s7ok4uw	2615	24	protein	protein	NN
cord-001835-0s7ok4uw	2615	25	stability	stability	NN
cord-001835-0s7ok4uw	2615	26	,	,	,
cord-001835-0s7ok4uw	2615	27	response	response	NN
cord-001835-0s7ok4uw	2615	28	to	to	IN
cord-001835-0s7ok4uw	2615	29	stress	stress	NN
cord-001835-0s7ok4uw	2615	30	,	,	,
cord-001835-0s7ok4uw	2615	31	and	and	CC
cord-001835-0s7ok4uw	2615	32	progression	progression	NN
cord-001835-0s7ok4uw	2615	33	through	through	IN
cord-001835-0s7ok4uw	2615	34	the	the	DT
cord-001835-0s7ok4uw	2615	35	cell	cell	NN
cord-001835-0s7ok4uw	2615	36	cycle	cycle	NN
cord-001835-0s7ok4uw	2615	37	.	.	.
cord-001835-0s7ok4uw	2616	1	SUMOylation	sumoylation	NN
cord-001835-0s7ok4uw	2616	2	is	be	VBZ
cord-001835-0s7ok4uw	2616	3	a	a	DT
cord-001835-0s7ok4uw	2616	4	conjugation	conjugation	NN
cord-001835-0s7ok4uw	2616	5	of	of	IN
cord-001835-0s7ok4uw	2616	6	glysine	glysine	JJ
cord-001835-0s7ok4uw	2616	7	residue	residue	NN
cord-001835-0s7ok4uw	2616	8	of	of	IN
cord-001835-0s7ok4uw	2616	9	SUMO	SUMO	NNP
cord-001835-0s7ok4uw	2616	10	protein	protein	NN
cord-001835-0s7ok4uw	2616	11	with	with	IN
cord-001835-0s7ok4uw	2616	12	lysine	lysine	NN
cord-001835-0s7ok4uw	2616	13	residue	residue	NN
cord-001835-0s7ok4uw	2616	14	in	in	IN
cord-001835-0s7ok4uw	2616	15	target(RanGAP1	target(rangap1	CD
cord-001835-0s7ok4uw	2616	16	)	)	-RRB-
cord-001835-0s7ok4uw	2616	17	protein	protein	NN
cord-001835-0s7ok4uw	2616	18	through	through	IN
cord-001835-0s7ok4uw	2616	19	the	the	DT
cord-001835-0s7ok4uw	2616	20	influence	influence	NN
cord-001835-0s7ok4uw	2616	21	of	of	IN
cord-001835-0s7ok4uw	2616	22	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2616	23	E2(Ubc9	E2(Ubc9	NNP
cord-001835-0s7ok4uw	2616	24	)	)	-RRB-
cord-001835-0s7ok4uw	2616	25	and	and	CC
cord-001835-0s7ok4uw	2616	26	E3(RanBP2	e3(ranbp2	NN
cord-001835-0s7ok4uw	2616	27	)	)	-RRB-
cord-001835-0s7ok4uw	2616	28	.	.	.
cord-001835-0s7ok4uw	2617	1	SUMO	SUMO	NNP
cord-001835-0s7ok4uw	2617	2	proteins	protein	NNS
cord-001835-0s7ok4uw	2617	3	modify	modify	VBP
cord-001835-0s7ok4uw	2617	4	the	the	DT
cord-001835-0s7ok4uw	2617	5	function	function	NN
cord-001835-0s7ok4uw	2617	6	of	of	IN
cord-001835-0s7ok4uw	2617	7	target	target	NN
cord-001835-0s7ok4uw	2617	8	protein	protein	NN
cord-001835-0s7ok4uw	2617	9	in	in	IN
cord-001835-0s7ok4uw	2617	10	the	the	DT
cord-001835-0s7ok4uw	2617	11	cell	cell	NN
cord-001835-0s7ok4uw	2617	12	.	.	.
cord-001835-0s7ok4uw	2618	1	But	but	CC
cord-001835-0s7ok4uw	2618	2	the	the	DT
cord-001835-0s7ok4uw	2618	3	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	2618	4	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2618	5	of	of	IN
cord-001835-0s7ok4uw	2618	6	SUMOylation	sumoylation	NN
cord-001835-0s7ok4uw	2618	7	is	be	VBZ
cord-001835-0s7ok4uw	2618	8	not	not	RB
cord-001835-0s7ok4uw	2618	9	well	well	RB
cord-001835-0s7ok4uw	2618	10	-	-	HYPH
cord-001835-0s7ok4uw	2618	11	understand	understand	NN
cord-001835-0s7ok4uw	2618	12	.	.	.
cord-001835-0s7ok4uw	2619	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2619	2	traced	trace	VBD
cord-001835-0s7ok4uw	2619	3	out	out	RP
cord-001835-0s7ok4uw	2619	4	the	the	DT
cord-001835-0s7ok4uw	2619	5	full	full	JJ
cord-001835-0s7ok4uw	2619	6	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	2619	7	process	process	NN
cord-001835-0s7ok4uw	2619	8	of	of	IN
cord-001835-0s7ok4uw	2619	9	SUMOylation	sumoylation	NN
cord-001835-0s7ok4uw	2619	10	of	of	IN
cord-001835-0s7ok4uw	2619	11	the	the	DT
cord-001835-0s7ok4uw	2619	12	SUMO1-Ubc9	sumo1-ubc9	JJ
cord-001835-0s7ok4uw	2619	13	-RanGAP1-RanBP2	-rangap1-ranbp2	NN
cord-001835-0s7ok4uw	2619	14	complex	complex	JJ
cord-001835-0s7ok4uw	2619	15	in	in	IN
cord-001835-0s7ok4uw	2619	16	atomic	atomic	JJ
cord-001835-0s7ok4uw	2619	17	detail	detail	NN
cord-001835-0s7ok4uw	2619	18	via	via	IN
cord-001835-0s7ok4uw	2619	19	molecular	molecular	JJ
cord-001835-0s7ok4uw	2619	20	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2619	21	simulation	simulation	NN
cord-001835-0s7ok4uw	2619	22	.	.	.
cord-001835-0s7ok4uw	2620	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2620	2	uncovered	uncover	VBD
cord-001835-0s7ok4uw	2620	3	the	the	DT
cord-001835-0s7ok4uw	2620	4	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2620	5	of	of	IN
cord-001835-0s7ok4uw	2620	6	SUMOylation	sumoylation	NN
cord-001835-0s7ok4uw	2620	7	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2620	8	and	and	CC
cord-001835-0s7ok4uw	2620	9	verified	verify	VBD
cord-001835-0s7ok4uw	2620	10	the	the	DT
cord-001835-0s7ok4uw	2620	11	important	important	JJ
cord-001835-0s7ok4uw	2620	12	residues	residue	NNS
cord-001835-0s7ok4uw	2620	13	which	which	WDT
cord-001835-0s7ok4uw	2620	14	play	play	VBP
cord-001835-0s7ok4uw	2620	15	a	a	DT
cord-001835-0s7ok4uw	2620	16	key	key	JJ
cord-001835-0s7ok4uw	2620	17	role	role	NN
cord-001835-0s7ok4uw	2620	18	in	in	IN
cord-001835-0s7ok4uw	2620	19	the	the	DT
cord-001835-0s7ok4uw	2620	20	SUMOylation	sumoylation	NN
cord-001835-0s7ok4uw	2620	21	process	process	NN
cord-001835-0s7ok4uw	2620	22	.	.	.
cord-001835-0s7ok4uw	2621	1	The	the	DT
cord-001835-0s7ok4uw	2621	2	comparison	comparison	NN
cord-001835-0s7ok4uw	2621	3	of	of	IN
cord-001835-0s7ok4uw	2621	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2621	5	results	result	NNS
cord-001835-0s7ok4uw	2621	6	with	with	IN
cord-001835-0s7ok4uw	2621	7	the	the	DT
cord-001835-0s7ok4uw	2621	8	experimental	experimental	JJ
cord-001835-0s7ok4uw	2621	9	one	one	NN
cord-001835-0s7ok4uw	2621	10	are	be	VBP
cord-001835-0s7ok4uw	2621	11	also	also	RB
cord-001835-0s7ok4uw	2621	12	discussed	discuss	VBN
cord-001835-0s7ok4uw	2621	13	.	.	.
cord-001835-0s7ok4uw	2622	1	Human	human	JJ
cord-001835-0s7ok4uw	2622	2	potassium	potassium	NN
cord-001835-0s7ok4uw	2622	3	channel	channel	NN
cord-001835-0s7ok4uw	2622	4	KCNQ1	KCNQ1	NNP
cord-001835-0s7ok4uw	2622	5	is	be	VBZ
cord-001835-0s7ok4uw	2622	6	expressed	express	VBN
cord-001835-0s7ok4uw	2622	7	in	in	IN
cord-001835-0s7ok4uw	2622	8	several	several	JJ
cord-001835-0s7ok4uw	2622	9	tissues	tissue	NNS
cord-001835-0s7ok4uw	2622	10	including	include	VBG
cord-001835-0s7ok4uw	2622	11	inner	inner	JJ
cord-001835-0s7ok4uw	2622	12	ear	ear	NN
cord-001835-0s7ok4uw	2622	13	,	,	,
cord-001835-0s7ok4uw	2622	14	heart	heart	NN
cord-001835-0s7ok4uw	2622	15	muscle	muscle	NN
cord-001835-0s7ok4uw	2622	16	,	,	,
cord-001835-0s7ok4uw	2622	17	lung	lung	NN
cord-001835-0s7ok4uw	2622	18	,	,	,
cord-001835-0s7ok4uw	2622	19	intestine	intestine	NN
cord-001835-0s7ok4uw	2622	20	,	,	,
cord-001835-0s7ok4uw	2622	21	and	and	CC
cord-001835-0s7ok4uw	2622	22	stomach	stomach	NN
cord-001835-0s7ok4uw	2622	23	,	,	,
cord-001835-0s7ok4uw	2622	24	each	each	DT
cord-001835-0s7ok4uw	2622	25	requiring	require	VBG
cord-001835-0s7ok4uw	2622	26	a	a	DT
cord-001835-0s7ok4uw	2622	27	unique	unique	JJ
cord-001835-0s7ok4uw	2622	28	current	current	JJ
cord-001835-0s7ok4uw	2622	29	profile	profile	NN
cord-001835-0s7ok4uw	2622	30	for	for	IN
cord-001835-0s7ok4uw	2622	31	proper	proper	JJ
cord-001835-0s7ok4uw	2622	32	function	function	NN
cord-001835-0s7ok4uw	2622	33	.	.	.
cord-001835-0s7ok4uw	2623	1	To	to	TO
cord-001835-0s7ok4uw	2623	2	tune	tune	VB
cord-001835-0s7ok4uw	2623	3	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2623	4	output	output	NN
cord-001835-0s7ok4uw	2623	5	current	current	NN
cord-001835-0s7ok4uw	2623	6	,	,	,
cord-001835-0s7ok4uw	2623	7	KCNQ1	KCNQ1	NNP
cord-001835-0s7ok4uw	2623	8	complexes	complex	NNS
cord-001835-0s7ok4uw	2623	9	with	with	IN
cord-001835-0s7ok4uw	2623	10	several	several	JJ
cord-001835-0s7ok4uw	2623	11	accessory	accessory	NN
cord-001835-0s7ok4uw	2623	12	proteins	protein	NNS
cord-001835-0s7ok4uw	2623	13	from	from	IN
cord-001835-0s7ok4uw	2623	14	the	the	DT
cord-001835-0s7ok4uw	2623	15	KCNE	KCNE	NNP
cord-001835-0s7ok4uw	2623	16	family	family	NN
cord-001835-0s7ok4uw	2623	17	,	,	,
cord-001835-0s7ok4uw	2623	18	each	each	DT
cord-001835-0s7ok4uw	2623	19	KCNE	KCNE	NNP
cord-001835-0s7ok4uw	2623	20	family	family	NN
cord-001835-0s7ok4uw	2623	21	member	member	NN
cord-001835-0s7ok4uw	2623	22	modulating	modulate	VBG
cord-001835-0s7ok4uw	2623	23	KCNQ1	KCNQ1	NNP
cord-001835-0s7ok4uw	2623	24	distinctly	distinctly	RB
cord-001835-0s7ok4uw	2623	25	:	:	:
cord-001835-0s7ok4uw	2623	26	KCNE1	KCNE1	NNP
cord-001835-0s7ok4uw	2623	27	causes	cause	VBZ
cord-001835-0s7ok4uw	2623	28	the	the	DT
cord-001835-0s7ok4uw	2623	29	channel	channel	NN
cord-001835-0s7ok4uw	2623	30	to	to	TO
cord-001835-0s7ok4uw	2623	31	delay	delay	VB
cord-001835-0s7ok4uw	2623	32	opening	opening	NN
cord-001835-0s7ok4uw	2623	33	and	and	CC
cord-001835-0s7ok4uw	2623	34	become	become	VB
cord-001835-0s7ok4uw	2623	35	more	more	RBR
cord-001835-0s7ok4uw	2623	36	conductive	conductive	JJ
cord-001835-0s7ok4uw	2623	37	in	in	IN
cord-001835-0s7ok4uw	2623	38	the	the	DT
cord-001835-0s7ok4uw	2623	39	open	open	JJ
cord-001835-0s7ok4uw	2623	40	state	state	NN
cord-001835-0s7ok4uw	2623	41	,	,	,
cord-001835-0s7ok4uw	2623	42	KCNE3	KCNE3	NNP
cord-001835-0s7ok4uw	2623	43	causes	cause	VBZ
cord-001835-0s7ok4uw	2623	44	the	the	DT
cord-001835-0s7ok4uw	2623	45	channel	channel	NN
cord-001835-0s7ok4uw	2623	46	to	to	TO
cord-001835-0s7ok4uw	2623	47	be	be	VB
cord-001835-0s7ok4uw	2623	48	constitutively	constitutively	RB
cord-001835-0s7ok4uw	2623	49	conductive	conductive	JJ
cord-001835-0s7ok4uw	2623	50	,	,	,
cord-001835-0s7ok4uw	2623	51	and	and	CC
cord-001835-0s7ok4uw	2623	52	KCNE4	KCNE4	NNP
cord-001835-0s7ok4uw	2623	53	closes	close	VBZ
cord-001835-0s7ok4uw	2623	54	the	the	DT
cord-001835-0s7ok4uw	2623	55	channel	channel	NN
cord-001835-0s7ok4uw	2623	56	.	.	.
cord-001835-0s7ok4uw	2624	1	The	the	DT
cord-001835-0s7ok4uw	2624	2	purpose	purpose	NN
cord-001835-0s7ok4uw	2624	3	of	of	IN
cord-001835-0s7ok4uw	2624	4	this	this	DT
cord-001835-0s7ok4uw	2624	5	study	study	NN
cord-001835-0s7ok4uw	2624	6	is	be	VBZ
cord-001835-0s7ok4uw	2624	7	to	to	TO
cord-001835-0s7ok4uw	2624	8	uncover	uncover	VB
cord-001835-0s7ok4uw	2624	9	the	the	DT
cord-001835-0s7ok4uw	2624	10	atomic	atomic	JJ
cord-001835-0s7ok4uw	2624	11	-	-	HYPH
cord-001835-0s7ok4uw	2624	12	scale	scale	NN
cord-001835-0s7ok4uw	2624	13	,	,	,
cord-001835-0s7ok4uw	2624	14	mechanical	mechanical	JJ
cord-001835-0s7ok4uw	2624	15	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2624	16	of	of	IN
cord-001835-0s7ok4uw	2624	17	how	how	WRB
cord-001835-0s7ok4uw	2624	18	KCNE3	KCNE3	NNP
cord-001835-0s7ok4uw	2624	19	modulates	modulate	VBZ
cord-001835-0s7ok4uw	2624	20	KCNQ1	KCNQ1	NNS
cord-001835-0s7ok4uw	2624	21	.	.	.
cord-001835-0s7ok4uw	2625	1	To	to	TO
cord-001835-0s7ok4uw	2625	2	do	do	VB
cord-001835-0s7ok4uw	2625	3	this	this	DT
cord-001835-0s7ok4uw	2625	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	2625	5	modeled	model	VBD
cord-001835-0s7ok4uw	2625	6	the	the	DT
cord-001835-0s7ok4uw	2625	7	interaction	interaction	NN
cord-001835-0s7ok4uw	2625	8	between	between	IN
cord-001835-0s7ok4uw	2625	9	KCNQ1	KCNQ1	NNS
cord-001835-0s7ok4uw	2625	10	and	and	CC
cord-001835-0s7ok4uw	2625	11	KCNE3	kcne3	XX
cord-001835-0s7ok4uw	2625	12	with	with	IN
cord-001835-0s7ok4uw	2625	13	a	a	DT
cord-001835-0s7ok4uw	2625	14	hybrid	hybrid	JJ
cord-001835-0s7ok4uw	2625	15	experimental	experimental	JJ
cord-001835-0s7ok4uw	2625	16	-	-	HYPH
cord-001835-0s7ok4uw	2625	17	computational	computational	JJ
cord-001835-0s7ok4uw	2625	18	approach	approach	NN
cord-001835-0s7ok4uw	2625	19	.	.	.
cord-001835-0s7ok4uw	2626	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2626	2	strategy	strategy	NN
cord-001835-0s7ok4uw	2626	3	is	be	VBZ
cord-001835-0s7ok4uw	2626	4	to	to	TO
cord-001835-0s7ok4uw	2626	5	determine	determine	VB
cord-001835-0s7ok4uw	2626	6	the	the	DT
cord-001835-0s7ok4uw	2626	7	NMR	NMR	NNP
cord-001835-0s7ok4uw	2626	8	structure	structure	NN
cord-001835-0s7ok4uw	2626	9	of	of	IN
cord-001835-0s7ok4uw	2626	10	KCNE3	KCNE3	NNP
cord-001835-0s7ok4uw	2626	11	alone	alone	RB
cord-001835-0s7ok4uw	2626	12	in	in	IN
cord-001835-0s7ok4uw	2626	13	bilayer	bilayer	NN
cord-001835-0s7ok4uw	2626	14	-	-	HYPH
cord-001835-0s7ok4uw	2626	15	mimicking	mimic	VBG
cord-001835-0s7ok4uw	2626	16	bicelles	bicelle	NNS
cord-001835-0s7ok4uw	2626	17	,	,	,
cord-001835-0s7ok4uw	2626	18	build	build	VB
cord-001835-0s7ok4uw	2626	19	a	a	DT
cord-001835-0s7ok4uw	2626	20	homology	homology	NN
cord-001835-0s7ok4uw	2626	21	model	model	NN
cord-001835-0s7ok4uw	2626	22	of	of	IN
cord-001835-0s7ok4uw	2626	23	the	the	DT
cord-001835-0s7ok4uw	2626	24	open	open	JJ
cord-001835-0s7ok4uw	2626	25	-	-	HYPH
cord-001835-0s7ok4uw	2626	26	state	state	NN
cord-001835-0s7ok4uw	2626	27	KCNQ1	KCNQ1	NNS
cord-001835-0s7ok4uw	2626	28	,	,	,
cord-001835-0s7ok4uw	2626	29	and	and	CC
cord-001835-0s7ok4uw	2626	30	dock	dock	VB
cord-001835-0s7ok4uw	2626	31	the	the	DT
cord-001835-0s7ok4uw	2626	32	structure	structure	NN
cord-001835-0s7ok4uw	2626	33	of	of	IN
cord-001835-0s7ok4uw	2626	34	KCNE3	KCNE3	NNP
cord-001835-0s7ok4uw	2626	35	onto	onto	IN
cord-001835-0s7ok4uw	2626	36	the	the	DT
cord-001835-0s7ok4uw	2626	37	model	model	NN
cord-001835-0s7ok4uw	2626	38	of	of	IN
cord-001835-0s7ok4uw	2626	39	KCNQ1	KCNQ1	NNS
cord-001835-0s7ok4uw	2626	40	using	use	VBG
cord-001835-0s7ok4uw	2626	41	electrophysiology	electrophysiology	VB
cord-001835-0s7ok4uw	2626	42	-	-	HYPH
cord-001835-0s7ok4uw	2626	43	based	base	VBN
cord-001835-0s7ok4uw	2626	44	restraints	restraint	NNS
cord-001835-0s7ok4uw	2626	45	to	to	TO
cord-001835-0s7ok4uw	2626	46	validate	validate	VB
cord-001835-0s7ok4uw	2626	47	and	and	CC
cord-001835-0s7ok4uw	2626	48	refine	refine	VB
cord-001835-0s7ok4uw	2626	49	the	the	DT
cord-001835-0s7ok4uw	2626	50	resulting	result	VBG
cord-001835-0s7ok4uw	2626	51	model	model	NN
cord-001835-0s7ok4uw	2626	52	complexes	complex	NNS
cord-001835-0s7ok4uw	2626	53	.	.	.
cord-001835-0s7ok4uw	2627	1	Paramagnetic	Paramagnetic	NNP
cord-001835-0s7ok4uw	2627	2	Relaxation	relaxation	NN
cord-001835-0s7ok4uw	2627	3	enhancement	enhancement	NN
cord-001835-0s7ok4uw	2627	4	,	,	,
cord-001835-0s7ok4uw	2627	5	residual	residual	JJ
cord-001835-0s7ok4uw	2627	6	dipolar	dipolar	JJ
cord-001835-0s7ok4uw	2627	7	coupling	coupling	NN
cord-001835-0s7ok4uw	2627	8	and	and	CC
cord-001835-0s7ok4uw	2627	9	sequence	sequence	NN
cord-001835-0s7ok4uw	2627	10	analysis	analysis	NN
cord-001835-0s7ok4uw	2627	11	suggest	suggest	VBP
cord-001835-0s7ok4uw	2627	12	the	the	DT
cord-001835-0s7ok4uw	2627	13	single	single	JJ
cord-001835-0s7ok4uw	2627	14	span	span	NN
cord-001835-0s7ok4uw	2627	15	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	2627	16	helix	helix	NN
cord-001835-0s7ok4uw	2627	17	of	of	IN
cord-001835-0s7ok4uw	2627	18	KCNE3	KCNE3	NNP
cord-001835-0s7ok4uw	2627	19	is	be	VBZ
cord-001835-0s7ok4uw	2627	20	significantly	significantly	RB
cord-001835-0s7ok4uw	2627	21	curved	curved	JJ
cord-001835-0s7ok4uw	2627	22	.	.	.
cord-001835-0s7ok4uw	2628	1	Hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2628	2	-	-	HYPH
cord-001835-0s7ok4uw	2628	3	deuterium	deuterium	NN
cord-001835-0s7ok4uw	2628	4	exchange	exchange	NN
cord-001835-0s7ok4uw	2628	5	,	,	,
cord-001835-0s7ok4uw	2628	6	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	2628	7	Overhauser	Overhauser	NNP
cord-001835-0s7ok4uw	2628	8	effect	effect	NN
cord-001835-0s7ok4uw	2628	9	cross	cross	NN
cord-001835-0s7ok4uw	2628	10	peaks	peak	NNS
cord-001835-0s7ok4uw	2628	11	,	,	,
cord-001835-0s7ok4uw	2628	12	and	and	CC
cord-001835-0s7ok4uw	2628	13	AMBER	AMBER	NNP
cord-001835-0s7ok4uw	2628	14	simulation	simulation	NN
cord-001835-0s7ok4uw	2628	15	suggest	suggest	VBP
cord-001835-0s7ok4uw	2628	16	KCNE3	KCNE3	NNP
cord-001835-0s7ok4uw	2628	17	carries	carry	VBZ
cord-001835-0s7ok4uw	2628	18	a	a	DT
cord-001835-0s7ok4uw	2628	19	significant	significant	JJ
cord-001835-0s7ok4uw	2628	20	amount	amount	NN
cord-001835-0s7ok4uw	2628	21	of	of	IN
cord-001835-0s7ok4uw	2628	22	water	water	NN
cord-001835-0s7ok4uw	2628	23	in	in	IN
cord-001835-0s7ok4uw	2628	24	the	the	DT
cord-001835-0s7ok4uw	2628	25	C	C	NNP
cord-001835-0s7ok4uw	2628	26	-	-	HYPH
cord-001835-0s7ok4uw	2628	27	terminal	terminal	NN
cord-001835-0s7ok4uw	2628	28	side	side	NN
cord-001835-0s7ok4uw	2628	29	of	of	IN
cord-001835-0s7ok4uw	2628	30	the	the	DT
cord-001835-0s7ok4uw	2628	31	transmembrane	transmembrane	NNP
cord-001835-0s7ok4uw	2628	32	helix	helix	NN
cord-001835-0s7ok4uw	2628	33	.	.	.
cord-001835-0s7ok4uw	2629	1	The	the	DT
cord-001835-0s7ok4uw	2629	2	1H-15N	1h-15n	CD
cord-001835-0s7ok4uw	2629	3	two	two	CD
cord-001835-0s7ok4uw	2629	4	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	2629	5	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	2629	6	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	2629	7	resonance	resonance	NN
cord-001835-0s7ok4uw	2629	8	spectra	spectrum	NNS
cord-001835-0s7ok4uw	2629	9	of	of	IN
cord-001835-0s7ok4uw	2629	10	a	a	DT
cord-001835-0s7ok4uw	2629	11	known	know	VBN
cord-001835-0s7ok4uw	2629	12	phenotype	phenotype	NN
cord-001835-0s7ok4uw	2629	13	-	-	HYPH
cord-001835-0s7ok4uw	2629	14	changing	change	VBG
cord-001835-0s7ok4uw	2629	15	mutation	mutation	NN
cord-001835-0s7ok4uw	2629	16	in	in	IN
cord-001835-0s7ok4uw	2629	17	the	the	DT
cord-001835-0s7ok4uw	2629	18	center	center	NN
cord-001835-0s7ok4uw	2629	19	of	of	IN
cord-001835-0s7ok4uw	2629	20	the	the	DT
cord-001835-0s7ok4uw	2629	21	transmembrane	transmembrane	NNP
cord-001835-0s7ok4uw	2629	22	helix	helix	NN
cord-001835-0s7ok4uw	2629	23	,	,	,
cord-001835-0s7ok4uw	2629	24	V72	V72	NNP
cord-001835-0s7ok4uw	2629	25	T	T	NNP
cord-001835-0s7ok4uw	2629	26	,	,	,
cord-001835-0s7ok4uw	2629	27	suggests	suggest	VBZ
cord-001835-0s7ok4uw	2629	28	the	the	DT
cord-001835-0s7ok4uw	2629	29	helix	helix	NN
cord-001835-0s7ok4uw	2629	30	adopts	adopt	VBZ
cord-001835-0s7ok4uw	2629	31	multiple	multiple	JJ
cord-001835-0s7ok4uw	2629	32	conformations	conformation	NNS
cord-001835-0s7ok4uw	2629	33	when	when	WRB
cord-001835-0s7ok4uw	2629	34	the	the	DT
cord-001835-0s7ok4uw	2629	35	extra	extra	JJ
cord-001835-0s7ok4uw	2629	36	side	side	NN
cord-001835-0s7ok4uw	2629	37	-	-	HYPH
cord-001835-0s7ok4uw	2629	38	chain	chain	NN
cord-001835-0s7ok4uw	2629	39	hydroxyl	hydroxyl	NN
cord-001835-0s7ok4uw	2629	40	group	group	NN
cord-001835-0s7ok4uw	2629	41	is	be	VBZ
cord-001835-0s7ok4uw	2629	42	present	present	JJ
cord-001835-0s7ok4uw	2629	43	.	.	.
cord-001835-0s7ok4uw	2630	1	A	a	DT
cord-001835-0s7ok4uw	2630	2	docking	docking	NN
cord-001835-0s7ok4uw	2630	3	funnel	funnel	NN
cord-001835-0s7ok4uw	2630	4	corroborates	corroborate	VBZ
cord-001835-0s7ok4uw	2630	5	a	a	DT
cord-001835-0s7ok4uw	2630	6	binding	bind	VBG
cord-001835-0s7ok4uw	2630	7	pocket	pocket	NN
cord-001835-0s7ok4uw	2630	8	suggested	suggest	VBN
cord-001835-0s7ok4uw	2630	9	by	by	IN
cord-001835-0s7ok4uw	2630	10	the	the	DT
cord-001835-0s7ok4uw	2630	11	in	in	IN
cord-001835-0s7ok4uw	2630	12	vivo	vivo	FW
cord-001835-0s7ok4uw	2630	13	electrophysiology	electrophysiology	NN
cord-001835-0s7ok4uw	2630	14	data	datum	NNS
cord-001835-0s7ok4uw	2630	15	where	where	WRB
cord-001835-0s7ok4uw	2630	16	KCNE3	kcne3	JJ
cord-001835-0s7ok4uw	2630	17	wedges	wedge	NNS
cord-001835-0s7ok4uw	2630	18	between	between	IN
cord-001835-0s7ok4uw	2630	19	a	a	DT
cord-001835-0s7ok4uw	2630	20	helix	helix	NN
cord-001835-0s7ok4uw	2630	21	near	near	IN
cord-001835-0s7ok4uw	2630	22	the	the	DT
cord-001835-0s7ok4uw	2630	23	potassium	potassium	NN
cord-001835-0s7ok4uw	2630	24	pore	pore	NN
cord-001835-0s7ok4uw	2630	25	and	and	CC
cord-001835-0s7ok4uw	2630	26	two	two	CD
cord-001835-0s7ok4uw	2630	27	helices	helix	NNS
cord-001835-0s7ok4uw	2630	28	in	in	IN
cord-001835-0s7ok4uw	2630	29	the	the	DT
cord-001835-0s7ok4uw	2630	30	voltage	voltage	NN
cord-001835-0s7ok4uw	2630	31	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	2630	32	element	element	NN
cord-001835-0s7ok4uw	2630	33	of	of	IN
cord-001835-0s7ok4uw	2630	34	the	the	DT
cord-001835-0s7ok4uw	2630	35	channel	channel	NN
cord-001835-0s7ok4uw	2630	36	.	.	.
cord-001835-0s7ok4uw	2631	1	Within	within	IN
cord-001835-0s7ok4uw	2631	2	this	this	DT
cord-001835-0s7ok4uw	2631	3	pocket	pocket	NN
cord-001835-0s7ok4uw	2631	4	,	,	,
cord-001835-0s7ok4uw	2631	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2631	6	believe	believe	VBP
cord-001835-0s7ok4uw	2631	7	the	the	DT
cord-001835-0s7ok4uw	2631	8	conformational	conformational	JJ
cord-001835-0s7ok4uw	2631	9	sampling	sampling	NN
cord-001835-0s7ok4uw	2631	10	and	and	CC
cord-001835-0s7ok4uw	2631	11	structural	structural	JJ
cord-001835-0s7ok4uw	2631	12	rigidity	rigidity	NN
cord-001835-0s7ok4uw	2631	13	-	-	:
cord-001835-0s7ok4uw	2631	14	or	or	CC
cord-001835-0s7ok4uw	2631	15	flexibility	flexibility	NN
cord-001835-0s7ok4uw	2631	16	,	,	,
cord-001835-0s7ok4uw	2631	17	in	in	IN
cord-001835-0s7ok4uw	2631	18	the	the	DT
cord-001835-0s7ok4uw	2631	19	context	context	NN
cord-001835-0s7ok4uw	2631	20	of	of	IN
cord-001835-0s7ok4uw	2631	21	the	the	DT
cord-001835-0s7ok4uw	2631	22	V72	V72	NNP
cord-001835-0s7ok4uw	2631	23	T	T	NNP
cord-001835-0s7ok4uw	2631	24	mutant	mutant	NN
cord-001835-0s7ok4uw	2631	25	-	-	:
cord-001835-0s7ok4uw	2631	26	of	of	IN
cord-001835-0s7ok4uw	2631	27	the	the	DT
cord-001835-0s7ok4uw	2631	28	accessory	accessory	NN
cord-001835-0s7ok4uw	2631	29	protein	protein	NN
cord-001835-0s7ok4uw	2631	30	KCNE3	kcne3	XX
cord-001835-0s7ok4uw	2631	31	directly	directly	RB
cord-001835-0s7ok4uw	2631	32	influence	influence	VBP
cord-001835-0s7ok4uw	2631	33	the	the	DT
cord-001835-0s7ok4uw	2631	34	modulation	modulation	NN
cord-001835-0s7ok4uw	2631	35	profile	profile	NN
cord-001835-0s7ok4uw	2631	36	.	.	.
cord-001835-0s7ok4uw	2632	1	Watching	watch	VBG
cord-001835-0s7ok4uw	2632	2	conformational	conformational	JJ
cord-001835-0s7ok4uw	2632	3	changes	change	NNS
cord-001835-0s7ok4uw	2632	4	in	in	IN
cord-001835-0s7ok4uw	2632	5	proteins	protein	NNS
cord-001835-0s7ok4uw	2632	6	by	by	IN
cord-001835-0s7ok4uw	2632	7	molecular	molecular	JJ
cord-001835-0s7ok4uw	2632	8	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2632	9	simulations	simulation	NNS
cord-001835-0s7ok4uw	2633	1	Kresten	Kresten	NNP
cord-001835-0s7ok4uw	2633	2	Lindorff	Lindorff	NNP
cord-001835-0s7ok4uw	2633	3	-	-	HYPH
cord-001835-0s7ok4uw	2633	4	Larsen	Larsen	NNP
cord-001835-0s7ok4uw	2633	5	1	1	CD
cord-001835-0s7ok4uw	2633	6	1	1	CD
cord-001835-0s7ok4uw	2633	7	Proteins	protein	NNS
cord-001835-0s7ok4uw	2633	8	are	be	VBP
cord-001835-0s7ok4uw	2633	9	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	2633	10	molecules	molecule	NNS
cord-001835-0s7ok4uw	2633	11	and	and	CC
cord-001835-0s7ok4uw	2633	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2633	13	ability	ability	NN
cord-001835-0s7ok4uw	2633	14	to	to	TO
cord-001835-0s7ok4uw	2633	15	adopt	adopt	VB
cord-001835-0s7ok4uw	2633	16	alternative	alternative	JJ
cord-001835-0s7ok4uw	2633	17	conformations	conformation	NNS
cord-001835-0s7ok4uw	2633	18	is	be	VBZ
cord-001835-0s7ok4uw	2633	19	central	central	JJ
cord-001835-0s7ok4uw	2633	20	to	to	IN
cord-001835-0s7ok4uw	2633	21	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2633	22	biological	biological	JJ
cord-001835-0s7ok4uw	2633	23	function	function	NN
cord-001835-0s7ok4uw	2633	24	.	.	.
cord-001835-0s7ok4uw	2634	1	Examples	example	NNS
cord-001835-0s7ok4uw	2634	2	include	include	VBP
cord-001835-0s7ok4uw	2634	3	motions	motion	NNS
cord-001835-0s7ok4uw	2634	4	that	that	WDT
cord-001835-0s7ok4uw	2634	5	underlie	underlie	VBP
cord-001835-0s7ok4uw	2634	6	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2634	7	regulation	regulation	NN
cord-001835-0s7ok4uw	2634	8	or	or	CC
cord-001835-0s7ok4uw	2634	9	ligand	ligand	NN
cord-001835-0s7ok4uw	2634	10	binding	binding	NN
cord-001835-0s7ok4uw	2634	11	,	,	,
cord-001835-0s7ok4uw	2634	12	or	or	CC
cord-001835-0s7ok4uw	2634	13	protein	protein	NN
cord-001835-0s7ok4uw	2634	14	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2634	15	in	in	IN
cord-001835-0s7ok4uw	2634	16	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	2634	17	that	that	WDT
cord-001835-0s7ok4uw	2634	18	can	can	MD
cord-001835-0s7ok4uw	2634	19	modulate	modulate	VB
cord-001835-0s7ok4uw	2634	20	the	the	DT
cord-001835-0s7ok4uw	2634	21	overall	overall	JJ
cord-001835-0s7ok4uw	2634	22	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2634	23	efficiency	efficiency	NN
cord-001835-0s7ok4uw	2634	24	.	.	.
cord-001835-0s7ok4uw	2635	1	Protein	protein	NN
cord-001835-0s7ok4uw	2635	2	motions	motion	NNS
cord-001835-0s7ok4uw	2635	3	can	can	MD
cord-001835-0s7ok4uw	2635	4	often	often	RB
cord-001835-0s7ok4uw	2635	5	be	be	VB
cord-001835-0s7ok4uw	2635	6	described	describe	VBN
cord-001835-0s7ok4uw	2635	7	as	as	IN
cord-001835-0s7ok4uw	2635	8	an	an	DT
cord-001835-0s7ok4uw	2635	9	exchange	exchange	NN
cord-001835-0s7ok4uw	2635	10	between	between	IN
cord-001835-0s7ok4uw	2635	11	a	a	DT
cord-001835-0s7ok4uw	2635	12	dominant	dominant	JJ
cord-001835-0s7ok4uw	2635	13	,	,	,
cord-001835-0s7ok4uw	2635	14	ground	ground	NN
cord-001835-0s7ok4uw	2635	15	state	state	NN
cord-001835-0s7ok4uw	2635	16	structure	structure	NN
cord-001835-0s7ok4uw	2635	17	and	and	CC
cord-001835-0s7ok4uw	2635	18	one	one	CD
cord-001835-0s7ok4uw	2635	19	or	or	CC
cord-001835-0s7ok4uw	2635	20	more	more	JJR
cord-001835-0s7ok4uw	2635	21	minor	minor	JJ
cord-001835-0s7ok4uw	2635	22	states	state	NNS
cord-001835-0s7ok4uw	2635	23	.	.	.
cord-001835-0s7ok4uw	2636	1	The	the	DT
cord-001835-0s7ok4uw	2636	2	structural	structural	JJ
cord-001835-0s7ok4uw	2636	3	and	and	CC
cord-001835-0s7ok4uw	2636	4	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	2636	5	properties	property	NNS
cord-001835-0s7ok4uw	2636	6	of	of	IN
cord-001835-0s7ok4uw	2636	7	these	these	DT
cord-001835-0s7ok4uw	2636	8	transiently	transiently	RB
cord-001835-0s7ok4uw	2636	9	and	and	CC
cord-001835-0s7ok4uw	2636	10	sparsely	sparsely	RB
cord-001835-0s7ok4uw	2636	11	populated	populated	JJ
cord-001835-0s7ok4uw	2636	12	states	state	NNS
cord-001835-0s7ok4uw	2636	13	are	be	VBP
cord-001835-0s7ok4uw	2636	14	,	,	,
cord-001835-0s7ok4uw	2636	15	however	however	RB
cord-001835-0s7ok4uw	2636	16	,	,	,
cord-001835-0s7ok4uw	2636	17	difficult	difficult	JJ
cord-001835-0s7ok4uw	2636	18	to	to	TO
cord-001835-0s7ok4uw	2636	19	study	study	VB
cord-001835-0s7ok4uw	2636	20	,	,	,
cord-001835-0s7ok4uw	2636	21	and	and	CC
cord-001835-0s7ok4uw	2636	22	an	an	DT
cord-001835-0s7ok4uw	2636	23	atomic	atomic	JJ
cord-001835-0s7ok4uw	2636	24	-	-	HYPH
cord-001835-0s7ok4uw	2636	25	level	level	NN
cord-001835-0s7ok4uw	2636	26	description	description	NN
cord-001835-0s7ok4uw	2636	27	of	of	IN
cord-001835-0s7ok4uw	2636	28	those	those	DT
cord-001835-0s7ok4uw	2636	29	states	state	NNS
cord-001835-0s7ok4uw	2636	30	is	be	VBZ
cord-001835-0s7ok4uw	2636	31	challenging	challenging	JJ
cord-001835-0s7ok4uw	2636	32	.	.	.
cord-001835-0s7ok4uw	2637	1	In	in	IN
cord-001835-0s7ok4uw	2637	2	an	an	DT
cord-001835-0s7ok4uw	2637	3	attempt	attempt	NN
cord-001835-0s7ok4uw	2637	4	to	to	TO
cord-001835-0s7ok4uw	2637	5	determine	determine	VB
cord-001835-0s7ok4uw	2637	6	how	how	WRB
cord-001835-0s7ok4uw	2637	7	well	well	RB
cord-001835-0s7ok4uw	2637	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	2637	9	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2637	10	simulations	simulation	NNS
cord-001835-0s7ok4uw	2637	11	can	can	MD
cord-001835-0s7ok4uw	2637	12	capture	capture	VB
cord-001835-0s7ok4uw	2637	13	slow	slow	JJ
cord-001835-0s7ok4uw	2637	14	,	,	,
cord-001835-0s7ok4uw	2637	15	conformational	conformational	JJ
cord-001835-0s7ok4uw	2637	16	changes	change	NNS
cord-001835-0s7ok4uw	2637	17	in	in	IN
cord-001835-0s7ok4uw	2637	18	protein	protein	NN
cord-001835-0s7ok4uw	2637	19	molecules	molecule	NNS
cord-001835-0s7ok4uw	2637	20	we	-PRON-	PRP
cord-001835-0s7ok4uw	2637	21	have	have	VBP
cord-001835-0s7ok4uw	2637	22	studied	study	VBN
cord-001835-0s7ok4uw	2637	23	two	two	CD
cord-001835-0s7ok4uw	2637	24	different	different	JJ
cord-001835-0s7ok4uw	2637	25	protein	protein	NN
cord-001835-0s7ok4uw	2637	26	systems	system	NNS
cord-001835-0s7ok4uw	2637	27	which	which	WDT
cord-001835-0s7ok4uw	2637	28	are	be	VBP
cord-001835-0s7ok4uw	2637	29	known	know	VBN
cord-001835-0s7ok4uw	2637	30	to	to	TO
cord-001835-0s7ok4uw	2637	31	undergo	undergo	VB
cord-001835-0s7ok4uw	2637	32	conformational	conformational	JJ
cord-001835-0s7ok4uw	2637	33	exchange	exchange	NN
cord-001835-0s7ok4uw	2637	34	on	on	IN
cord-001835-0s7ok4uw	2637	35	the	the	DT
cord-001835-0s7ok4uw	2637	36	millisecond	millisecond	NN
cord-001835-0s7ok4uw	2637	37	timescale	timescale	NN
cord-001835-0s7ok4uw	2637	38	,	,	,
cord-001835-0s7ok4uw	2637	39	and	and	CC
cord-001835-0s7ok4uw	2637	40	for	for	IN
cord-001835-0s7ok4uw	2637	41	which	which	WDT
cord-001835-0s7ok4uw	2637	42	structural	structural	JJ
cord-001835-0s7ok4uw	2637	43	information	information	NN
cord-001835-0s7ok4uw	2637	44	is	be	VBZ
cord-001835-0s7ok4uw	2637	45	available	available	JJ
cord-001835-0s7ok4uw	2637	46	for	for	IN
cord-001835-0s7ok4uw	2637	47	both	both	DT
cord-001835-0s7ok4uw	2637	48	major	major	JJ
cord-001835-0s7ok4uw	2637	49	and	and	CC
cord-001835-0s7ok4uw	2637	50	minor	minor	JJ
cord-001835-0s7ok4uw	2637	51	states	state	NNS
cord-001835-0s7ok4uw	2637	52	.	.	.
cord-001835-0s7ok4uw	2638	1	Using	use	VBG
cord-001835-0s7ok4uw	2638	2	enhanced	enhance	VBN
cord-001835-0s7ok4uw	2638	3	-	-	HYPH
cord-001835-0s7ok4uw	2638	4	sampling	sampling	NN
cord-001835-0s7ok4uw	2638	5	all	all	DT
cord-001835-0s7ok4uw	2638	6	-	-	HYPH
cord-001835-0s7ok4uw	2638	7	atom	atom	NN
cord-001835-0s7ok4uw	2638	8	,	,	,
cord-001835-0s7ok4uw	2638	9	explicit	explicit	JJ
cord-001835-0s7ok4uw	2638	10	-	-	HYPH
cord-001835-0s7ok4uw	2638	11	solvent	solvent	NN
cord-001835-0s7ok4uw	2638	12	molecular	molecular	JJ
cord-001835-0s7ok4uw	2638	13	simulations	simulation	NNS
cord-001835-0s7ok4uw	2638	14	,	,	,
cord-001835-0s7ok4uw	2638	15	guided	guide	VBN
cord-001835-0s7ok4uw	2638	16	by	by	IN
cord-001835-0s7ok4uw	2638	17	structural	structural	JJ
cord-001835-0s7ok4uw	2638	18	information	information	NN
cord-001835-0s7ok4uw	2638	19	from	from	IN
cord-001835-0s7ok4uw	2638	20	X	x	NN
cord-001835-0s7ok4uw	2638	21	-	-	NN
cord-001835-0s7ok4uw	2638	22	ray	ray	NN
cord-001835-0s7ok4uw	2638	23	crystallography	crystallography	NN
cord-001835-0s7ok4uw	2638	24	and	and	CC
cord-001835-0s7ok4uw	2638	25	NMR	NMR	NNP
cord-001835-0s7ok4uw	2638	26	,	,	,
cord-001835-0s7ok4uw	2638	27	we	-PRON-	PRP
cord-001835-0s7ok4uw	2638	28	show	show	VBP
cord-001835-0s7ok4uw	2638	29	that	that	IN
cord-001835-0s7ok4uw	2638	30	current	current	JJ
cord-001835-0s7ok4uw	2638	31	force	force	NN
cord-001835-0s7ok4uw	2638	32	fields	field	NNS
cord-001835-0s7ok4uw	2638	33	and	and	CC
cord-001835-0s7ok4uw	2638	34	sampling	sampling	NN
cord-001835-0s7ok4uw	2638	35	methods	method	NNS
cord-001835-0s7ok4uw	2638	36	allow	allow	VBP
cord-001835-0s7ok4uw	2638	37	us	-PRON-	PRP
cord-001835-0s7ok4uw	2638	38	to	to	TO
cord-001835-0s7ok4uw	2638	39	sample	sample	VB
cord-001835-0s7ok4uw	2638	40	experimentally	experimentally	RB
cord-001835-0s7ok4uw	2638	41	-	-	HYPH
cord-001835-0s7ok4uw	2638	42	determined	determine	VBN
cord-001835-0s7ok4uw	2638	43	alternative	alternative	JJ
cord-001835-0s7ok4uw	2638	44	conformations	conformation	NNS
cord-001835-0s7ok4uw	2638	45	with	with	IN
cord-001835-0s7ok4uw	2638	46	surprisingly	surprisingly	RB
cord-001835-0s7ok4uw	2638	47	high	high	JJ
cord-001835-0s7ok4uw	2638	48	accuracy	accuracy	NN
cord-001835-0s7ok4uw	2638	49	.	.	.
cord-001835-0s7ok4uw	2639	1	In	in	IN
cord-001835-0s7ok4uw	2639	2	particular	particular	JJ
cord-001835-0s7ok4uw	2639	3	,	,	,
cord-001835-0s7ok4uw	2639	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	2639	5	find	find	VBP
cord-001835-0s7ok4uw	2639	6	that	that	IN
cord-001835-0s7ok4uw	2639	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	2639	8	can	can	MD
cord-001835-0s7ok4uw	2639	9	reversible	reversible	VB
cord-001835-0s7ok4uw	2639	10	sample	sample	NN
cord-001835-0s7ok4uw	2639	11	both	both	CC
cord-001835-0s7ok4uw	2639	12	the	the	DT
cord-001835-0s7ok4uw	2639	13	ground	ground	NN
cord-001835-0s7ok4uw	2639	14	state	state	NN
cord-001835-0s7ok4uw	2639	15	and	and	CC
cord-001835-0s7ok4uw	2639	16	minor	minor	JJ
cord-001835-0s7ok4uw	2639	17	state	state	NN
cord-001835-0s7ok4uw	2639	18	,	,	,
cord-001835-0s7ok4uw	2639	19	and	and	CC
cord-001835-0s7ok4uw	2639	20	that	that	IN
cord-001835-0s7ok4uw	2639	21	the	the	DT
cord-001835-0s7ok4uw	2639	22	simulations	simulation	NNS
cord-001835-0s7ok4uw	2639	23	capture	capture	VBP
cord-001835-0s7ok4uw	2639	24	the	the	DT
cord-001835-0s7ok4uw	2639	25	structure	structure	NN
cord-001835-0s7ok4uw	2639	26	of	of	IN
cord-001835-0s7ok4uw	2639	27	the	the	DT
cord-001835-0s7ok4uw	2639	28	minor	minor	JJ
cord-001835-0s7ok4uw	2639	29	states	state	NNS
cord-001835-0s7ok4uw	2639	30	also	also	RB
cord-001835-0s7ok4uw	2639	31	.	.	.
cord-001835-0s7ok4uw	2640	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2640	2	simulations	simulation	NNS
cord-001835-0s7ok4uw	2640	3	enable	enable	VBP
cord-001835-0s7ok4uw	2640	4	us	-PRON-	PRP
cord-001835-0s7ok4uw	2640	5	to	to	TO
cord-001835-0s7ok4uw	2640	6	calculate	calculate	VB
cord-001835-0s7ok4uw	2640	7	the	the	DT
cord-001835-0s7ok4uw	2640	8	conformational	conformational	JJ
cord-001835-0s7ok4uw	2640	9	free	free	JJ
cord-001835-0s7ok4uw	2640	10	energy	energy	NN
cord-001835-0s7ok4uw	2640	11	between	between	IN
cord-001835-0s7ok4uw	2640	12	the	the	DT
cord-001835-0s7ok4uw	2640	13	two	two	CD
cord-001835-0s7ok4uw	2640	14	states	state	NNS
cord-001835-0s7ok4uw	2640	15	,	,	,
cord-001835-0s7ok4uw	2640	16	and	and	CC
cord-001835-0s7ok4uw	2640	17	comparison	comparison	NN
cord-001835-0s7ok4uw	2640	18	with	with	IN
cord-001835-0s7ok4uw	2640	19	relaxation	relaxation	NN
cord-001835-0s7ok4uw	2640	20	dispersion	dispersion	NN
cord-001835-0s7ok4uw	2640	21	NMR	NMR	NNP
cord-001835-0s7ok4uw	2640	22	experiments	experiment	NNS
cord-001835-0s7ok4uw	2640	23	demonstrates	demonstrate	VBZ
cord-001835-0s7ok4uw	2640	24	a	a	DT
cord-001835-0s7ok4uw	2640	25	high	high	JJ
cord-001835-0s7ok4uw	2640	26	accuracy	accuracy	NN
cord-001835-0s7ok4uw	2640	27	.	.	.
cord-001835-0s7ok4uw	2641	1	Thus	thus	RB
cord-001835-0s7ok4uw	2641	2	,	,	,
cord-001835-0s7ok4uw	2641	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2641	4	show	show	VBP
cord-001835-0s7ok4uw	2641	5	for	for	IN
cord-001835-0s7ok4uw	2641	6	two	two	CD
cord-001835-0s7ok4uw	2641	7	distinct	distinct	JJ
cord-001835-0s7ok4uw	2641	8	proteins	protein	NNS
cord-001835-0s7ok4uw	2641	9	that	that	IN
cord-001835-0s7ok4uw	2641	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	2641	11	can	can	MD
cord-001835-0s7ok4uw	2641	12	map	map	VB
cord-001835-0s7ok4uw	2641	13	the	the	DT
cord-001835-0s7ok4uw	2641	14	free	free	JJ
cord-001835-0s7ok4uw	2641	15	energy	energy	NN
cord-001835-0s7ok4uw	2641	16	landscapes	landscape	NNS
cord-001835-0s7ok4uw	2641	17	and	and	CC
cord-001835-0s7ok4uw	2641	18	that	that	IN
cord-001835-0s7ok4uw	2641	19	both	both	CC
cord-001835-0s7ok4uw	2641	20	the	the	DT
cord-001835-0s7ok4uw	2641	21	structure	structure	NN
cord-001835-0s7ok4uw	2641	22	and	and	CC
cord-001835-0s7ok4uw	2641	23	energetics	energetic	NNS
cord-001835-0s7ok4uw	2641	24	are	be	VBP
cord-001835-0s7ok4uw	2641	25	in	in	IN
cord-001835-0s7ok4uw	2641	26	excellent	excellent	JJ
cord-001835-0s7ok4uw	2641	27	agreement	agreement	NN
cord-001835-0s7ok4uw	2641	28	with	with	IN
cord-001835-0s7ok4uw	2641	29	NMR	NMR	NNP
cord-001835-0s7ok4uw	2641	30	experiments	experiment	NNS
cord-001835-0s7ok4uw	2641	31	.	.	.
cord-001835-0s7ok4uw	2642	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2642	2	simulations	simulation	NNS
cord-001835-0s7ok4uw	2642	3	provide	provide	VBP
cord-001835-0s7ok4uw	2642	4	insight	insight	NN
cord-001835-0s7ok4uw	2642	5	into	into	IN
cord-001835-0s7ok4uw	2642	6	the	the	DT
cord-001835-0s7ok4uw	2642	7	structural	structural	JJ
cord-001835-0s7ok4uw	2642	8	and	and	CC
cord-001835-0s7ok4uw	2642	9	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	2642	10	properties	property	NNS
cord-001835-0s7ok4uw	2642	11	of	of	IN
cord-001835-0s7ok4uw	2642	12	transiently	transiently	RB
cord-001835-0s7ok4uw	2642	13	populated	populate	VBN
cord-001835-0s7ok4uw	2642	14	minor	minor	JJ
cord-001835-0s7ok4uw	2642	15	states	state	NNS
cord-001835-0s7ok4uw	2642	16	,	,	,
cord-001835-0s7ok4uw	2642	17	and	and	CC
cord-001835-0s7ok4uw	2642	18	help	help	VB
cord-001835-0s7ok4uw	2642	19	reinterpret	reinterpret	VB
cord-001835-0s7ok4uw	2642	20	previous	previous	JJ
cord-001835-0s7ok4uw	2642	21	experimental	experimental	JJ
cord-001835-0s7ok4uw	2642	22	measurements	measurement	NNS
cord-001835-0s7ok4uw	2642	23	.	.	.
cord-001835-0s7ok4uw	2643	1	Further	further	RB
cord-001835-0s7ok4uw	2643	2	,	,	,
cord-001835-0s7ok4uw	2643	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2643	4	results	result	NNS
cord-001835-0s7ok4uw	2643	5	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	2643	6	that	that	IN
cord-001835-0s7ok4uw	2643	7	,	,	,
cord-001835-0s7ok4uw	2643	8	at	at	IN
cord-001835-0s7ok4uw	2643	9	least	least	JJS
cord-001835-0s7ok4uw	2643	10	in	in	IN
cord-001835-0s7ok4uw	2643	11	the	the	DT
cord-001835-0s7ok4uw	2643	12	two	two	CD
cord-001835-0s7ok4uw	2643	13	cases	case	NNS
cord-001835-0s7ok4uw	2643	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	2643	15	have	have	VBP
cord-001835-0s7ok4uw	2643	16	studied	study	VBN
cord-001835-0s7ok4uw	2643	17	,	,	,
cord-001835-0s7ok4uw	2643	18	modern	modern	JJ
cord-001835-0s7ok4uw	2643	19	simulation	simulation	NN
cord-001835-0s7ok4uw	2643	20	methods	method	NNS
cord-001835-0s7ok4uw	2643	21	enable	enable	VBP
cord-001835-0s7ok4uw	2643	22	us	-PRON-	PRP
cord-001835-0s7ok4uw	2643	23	to	to	TO
cord-001835-0s7ok4uw	2643	24	examine	examine	VB
cord-001835-0s7ok4uw	2643	25	these	these	DT
cord-001835-0s7ok4uw	2643	26	otherwise	otherwise	RB
cord-001835-0s7ok4uw	2643	27	"	"	``
cord-001835-0s7ok4uw	2643	28	invisible	invisible	JJ
cord-001835-0s7ok4uw	2643	29	"	"	''
cord-001835-0s7ok4uw	2643	30	states	state	NNS
cord-001835-0s7ok4uw	2643	31	of	of	IN
cord-001835-0s7ok4uw	2643	32	proteins	protein	NNS
cord-001835-0s7ok4uw	2643	33	and	and	CC
cord-001835-0s7ok4uw	2643	34	describe	describe	VBP
cord-001835-0s7ok4uw	2643	35	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2643	36	structural	structural	JJ
cord-001835-0s7ok4uw	2643	37	,	,	,
cord-001835-0s7ok4uw	2643	38	functional	functional	JJ
cord-001835-0s7ok4uw	2643	39	and	and	CC
cord-001835-0s7ok4uw	2643	40	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	2643	41	properties	property	NNS
cord-001835-0s7ok4uw	2643	42	.	.	.
cord-001835-0s7ok4uw	2644	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2644	2	results	result	NNS
cord-001835-0s7ok4uw	2644	3	in	in	IN
cord-001835-0s7ok4uw	2644	4	this	this	DT
cord-001835-0s7ok4uw	2644	5	way	way	NN
cord-001835-0s7ok4uw	2644	6	help	help	VB
cord-001835-0s7ok4uw	2644	7	demonstrate	demonstrate	VB
cord-001835-0s7ok4uw	2644	8	how	how	WRB
cord-001835-0s7ok4uw	2644	9	simulations	simulation	NNS
cord-001835-0s7ok4uw	2644	10	can	can	MD
cord-001835-0s7ok4uw	2644	11	now	now	RB
cord-001835-0s7ok4uw	2644	12	add	add	VB
cord-001835-0s7ok4uw	2644	13	to	to	IN
cord-001835-0s7ok4uw	2644	14	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2644	15	knowledge	knowledge	NN
cord-001835-0s7ok4uw	2644	16	of	of	IN
cord-001835-0s7ok4uw	2644	17	transiently	transiently	RB
cord-001835-0s7ok4uw	2644	18	formed	form	VBN
cord-001835-0s7ok4uw	2644	19	,	,	,
cord-001835-0s7ok4uw	2644	20	"	"	``
cord-001835-0s7ok4uw	2644	21	hidden	hide	VBN
cord-001835-0s7ok4uw	2644	22	"	"	''
cord-001835-0s7ok4uw	2644	23	states	state	NNS
cord-001835-0s7ok4uw	2644	24	of	of	IN
cord-001835-0s7ok4uw	2644	25	proteins	protein	NNS
cord-001835-0s7ok4uw	2644	26	.	.	.
cord-001835-0s7ok4uw	2645	1	Cell	cell	NN
cord-001835-0s7ok4uw	2645	2	signaling	signaling	NN
cord-001835-0s7ok4uw	2645	3	is	be	VBZ
cord-001835-0s7ok4uw	2645	4	a	a	DT
cord-001835-0s7ok4uw	2645	5	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	2645	6	process	process	NN
cord-001835-0s7ok4uw	2645	7	for	for	IN
cord-001835-0s7ok4uw	2645	8	all	all	DT
cord-001835-0s7ok4uw	2645	9	living	live	VBG
cord-001835-0s7ok4uw	2645	10	organisms	organism	NNS
cord-001835-0s7ok4uw	2645	11	.	.	.
cord-001835-0s7ok4uw	2646	1	G	g	NN
cord-001835-0s7ok4uw	2646	2	protein	protein	NN
cord-001835-0s7ok4uw	2646	3	-	-	HYPH
cord-001835-0s7ok4uw	2646	4	coupled	couple	VBN
cord-001835-0s7ok4uw	2646	5	receptors	receptor	NNS
cord-001835-0s7ok4uw	2646	6	(	(	-LRB-
cord-001835-0s7ok4uw	2646	7	GPCRs	GPCRs	NNP
cord-001835-0s7ok4uw	2646	8	)	)	-RRB-
cord-001835-0s7ok4uw	2646	9	are	be	VBP
cord-001835-0s7ok4uw	2646	10	a	a	DT
cord-001835-0s7ok4uw	2646	11	large	large	JJ
cord-001835-0s7ok4uw	2646	12	and	and	CC
cord-001835-0s7ok4uw	2646	13	diverse	diverse	JJ
cord-001835-0s7ok4uw	2646	14	group	group	NN
cord-001835-0s7ok4uw	2646	15	of	of	IN
cord-001835-0s7ok4uw	2646	16	transmembrane	transmembrane	NNP
cord-001835-0s7ok4uw	2646	17	receptors	receptor	NNS
cord-001835-0s7ok4uw	2646	18	which	which	WDT
cord-001835-0s7ok4uw	2646	19	convert	convert	VBP
cord-001835-0s7ok4uw	2646	20	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	2646	21	signals	signal	NNS
cord-001835-0s7ok4uw	2646	22	into	into	IN
cord-001835-0s7ok4uw	2646	23	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	2646	24	responses	response	NNS
cord-001835-0s7ok4uw	2646	25	primarily	primarily	RB
cord-001835-0s7ok4uw	2646	26	via	via	IN
cord-001835-0s7ok4uw	2646	27	coupling	coupling	NN
cord-001835-0s7ok4uw	2646	28	to	to	IN
cord-001835-0s7ok4uw	2646	29	heterotrimeric	heterotrimeric	JJ
cord-001835-0s7ok4uw	2646	30	G	g	NN
cord-001835-0s7ok4uw	2646	31	proteins	protein	NNS
cord-001835-0s7ok4uw	2646	32	.	.	.
cord-001835-0s7ok4uw	2647	1	In	in	IN
cord-001835-0s7ok4uw	2647	2	order	order	NN
cord-001835-0s7ok4uw	2647	3	to	to	TO
cord-001835-0s7ok4uw	2647	4	integrate	integrate	VB
cord-001835-0s7ok4uw	2647	5	the	the	DT
cord-001835-0s7ok4uw	2647	6	range	range	NN
cord-001835-0s7ok4uw	2647	7	of	of	IN
cord-001835-0s7ok4uw	2647	8	very	very	RB
cord-001835-0s7ok4uw	2647	9	diverse	diverse	JJ
cord-001835-0s7ok4uw	2647	10	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	2647	11	signals	signal	NNS
cord-001835-0s7ok4uw	2647	12	into	into	IN
cord-001835-0s7ok4uw	2647	13	a	a	DT
cord-001835-0s7ok4uw	2647	14	message	message	NN
cord-001835-0s7ok4uw	2647	15	the	the	DT
cord-001835-0s7ok4uw	2647	16	cell	cell	NN
cord-001835-0s7ok4uw	2647	17	can	can	MD
cord-001835-0s7ok4uw	2647	18	recognize	recognize	VB
cord-001835-0s7ok4uw	2647	19	and	and	CC
cord-001835-0s7ok4uw	2647	20	respond	respond	VB
cord-001835-0s7ok4uw	2647	21	to	to	IN
cord-001835-0s7ok4uw	2647	22	,	,	,
cord-001835-0s7ok4uw	2647	23	conformational	conformational	JJ
cord-001835-0s7ok4uw	2647	24	changes	change	NNS
cord-001835-0s7ok4uw	2647	25	occur	occur	VBP
cord-001835-0s7ok4uw	2647	26	that	that	WDT
cord-001835-0s7ok4uw	2647	27	rewire	rewire	VBP
cord-001835-0s7ok4uw	2647	28	the	the	DT
cord-001835-0s7ok4uw	2647	29	interactions	interaction	NNS
cord-001835-0s7ok4uw	2647	30	between	between	IN
cord-001835-0s7ok4uw	2647	31	the	the	DT
cord-001835-0s7ok4uw	2647	32	receptor	receptor	NN
cord-001835-0s7ok4uw	2647	33	and	and	CC
cord-001835-0s7ok4uw	2647	34	heterotrimer	heterotrimer	NN
cord-001835-0s7ok4uw	2647	35	in	in	IN
cord-001835-0s7ok4uw	2647	36	a	a	DT
cord-001835-0s7ok4uw	2647	37	specific	specific	JJ
cord-001835-0s7ok4uw	2647	38	and	and	CC
cord-001835-0s7ok4uw	2647	39	coordinated	coordinated	JJ
cord-001835-0s7ok4uw	2647	40	manner	manner	NN
cord-001835-0s7ok4uw	2647	41	.	.	.
cord-001835-0s7ok4uw	2648	1	By	by	IN
cord-001835-0s7ok4uw	2648	2	interrogating	interrogate	VBG
cord-001835-0s7ok4uw	2648	3	the	the	DT
cord-001835-0s7ok4uw	2648	4	energetics	energetic	NNS
cord-001835-0s7ok4uw	2648	5	of	of	IN
cord-001835-0s7ok4uw	2648	6	these	these	DT
cord-001835-0s7ok4uw	2648	7	interactions	interaction	NNS
cord-001835-0s7ok4uw	2648	8	within	within	IN
cord-001835-0s7ok4uw	2648	9	the	the	DT
cord-001835-0s7ok4uw	2648	10	individual	individual	JJ
cord-001835-0s7ok4uw	2648	11	proteins	protein	NNS
cord-001835-0s7ok4uw	2648	12	and	and	CC
cord-001835-0s7ok4uw	2648	13	across	across	IN
cord-001835-0s7ok4uw	2648	14	protein	protein	NN
cord-001835-0s7ok4uw	2648	15	-	-	HYPH
cord-001835-0s7ok4uw	2648	16	protein	protein	NN
cord-001835-0s7ok4uw	2648	17	interfaces	interface	NNS
cord-001835-0s7ok4uw	2648	18	,	,	,
cord-001835-0s7ok4uw	2648	19	a	a	DT
cord-001835-0s7ok4uw	2648	20	communication	communication	NN
cord-001835-0s7ok4uw	2648	21	network	network	NN
cord-001835-0s7ok4uw	2648	22	between	between	IN
cord-001835-0s7ok4uw	2648	23	amino	amino	JJ
cord-001835-0s7ok4uw	2648	24	acids	acid	NNS
cord-001835-0s7ok4uw	2648	25	involved	involve	VBN
cord-001835-0s7ok4uw	2648	26	in	in	IN
cord-001835-0s7ok4uw	2648	27	conformational	conformational	JJ
cord-001835-0s7ok4uw	2648	28	changes	change	NNS
cord-001835-0s7ok4uw	2648	29	for	for	IN
cord-001835-0s7ok4uw	2648	30	signaling	signal	VBG
cord-001835-0s7ok4uw	2648	31	,	,	,
cord-001835-0s7ok4uw	2648	32	is	be	VBZ
cord-001835-0s7ok4uw	2648	33	created	create	VBN
cord-001835-0s7ok4uw	2648	34	.	.	.
cord-001835-0s7ok4uw	2649	1	To	to	TO
cord-001835-0s7ok4uw	2649	2	construct	construct	VB
cord-001835-0s7ok4uw	2649	3	this	this	DT
cord-001835-0s7ok4uw	2649	4	mapping	mapping	NN
cord-001835-0s7ok4uw	2649	5	of	of	IN
cord-001835-0s7ok4uw	2649	6	pairwise	pairwise	JJ
cord-001835-0s7ok4uw	2649	7	interaction	interaction	NN
cord-001835-0s7ok4uw	2649	8	energies	energy	NNS
cord-001835-0s7ok4uw	2649	9	in	in	IN
cord-001835-0s7ok4uw	2649	10	silico	silico	NN
cord-001835-0s7ok4uw	2649	11	,	,	,
cord-001835-0s7ok4uw	2649	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	2649	13	analyzed	analyze	VBD
cord-001835-0s7ok4uw	2649	14	Rhodopsin	Rhodopsin	NNP
cord-001835-0s7ok4uw	2649	15	GPCR	GPCR	NNP
cord-001835-0s7ok4uw	2649	16	coupled	couple	VBD
cord-001835-0s7ok4uw	2649	17	to	to	IN
cord-001835-0s7ok4uw	2649	18	a	a	DT
cord-001835-0s7ok4uw	2649	19	Gai1b1g1	Gai1b1g1	NNP
cord-001835-0s7ok4uw	2649	20	heterotrimer	heterotrimer	NNP
cord-001835-0s7ok4uw	2649	21	.	.	.
cord-001835-0s7ok4uw	2650	1	The	the	DT
cord-001835-0s7ok4uw	2650	2	structure	structure	NN
cord-001835-0s7ok4uw	2650	3	of	of	IN
cord-001835-0s7ok4uw	2650	4	this	this	DT
cord-001835-0s7ok4uw	2650	5	G	g	NN
cord-001835-0s7ok4uw	2650	6	protein	protein	NN
cord-001835-0s7ok4uw	2650	7	complex	complex	NN
cord-001835-0s7ok4uw	2650	8	was	be	VBD
cord-001835-0s7ok4uw	2650	9	modeled	model	VBN
cord-001835-0s7ok4uw	2650	10	in	in	IN
cord-001835-0s7ok4uw	2650	11	the	the	DT
cord-001835-0s7ok4uw	2650	12	receptor	receptor	NN
cord-001835-0s7ok4uw	2650	13	-	-	HYPH
cord-001835-0s7ok4uw	2650	14	bound	bind	VBN
cord-001835-0s7ok4uw	2650	15	and	and	CC
cord-001835-0s7ok4uw	2650	16	unbound	unbound	JJ
cord-001835-0s7ok4uw	2650	17	heterotrimeric	heterotrimeric	JJ
cord-001835-0s7ok4uw	2650	18	states	state	NNS
cord-001835-0s7ok4uw	2650	19	as	as	RB
cord-001835-0s7ok4uw	2650	20	well	well	RB
cord-001835-0s7ok4uw	2650	21	as	as	IN
cord-001835-0s7ok4uw	2650	22	the	the	DT
cord-001835-0s7ok4uw	2650	23	activated	activate	VBN
cord-001835-0s7ok4uw	2650	24	,	,	,
cord-001835-0s7ok4uw	2650	25	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	2650	26	Ga(GTP	ga(gtp	CD
cord-001835-0s7ok4uw	2650	27	)	)	-RRB-
cord-001835-0s7ok4uw	2650	28	state	state	NN
cord-001835-0s7ok4uw	2650	29	.	.	.
cord-001835-0s7ok4uw	2651	1	From	from	IN
cord-001835-0s7ok4uw	2651	2	these	these	DT
cord-001835-0s7ok4uw	2651	3	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	2651	4	structural	structural	JJ
cord-001835-0s7ok4uw	2651	5	models	model	NNS
cord-001835-0s7ok4uw	2651	6	,	,	,
cord-001835-0s7ok4uw	2651	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	2651	8	computed	compute	VBD
cord-001835-0s7ok4uw	2651	9	the	the	DT
cord-001835-0s7ok4uw	2651	10	average	average	JJ
cord-001835-0s7ok4uw	2651	11	pairwise	pairwise	JJ
cord-001835-0s7ok4uw	2651	12	residue	residue	NN
cord-001835-0s7ok4uw	2651	13	-	-	HYPH
cord-001835-0s7ok4uw	2651	14	residue	residue	NN
cord-001835-0s7ok4uw	2651	15	interactions	interaction	NNS
cord-001835-0s7ok4uw	2651	16	and	and	CC
cord-001835-0s7ok4uw	2651	17	interface	interface	NN
cord-001835-0s7ok4uw	2651	18	energies	energy	NNS
cord-001835-0s7ok4uw	2651	19	across	across	IN
cord-001835-0s7ok4uw	2651	20	ten	ten	CD
cord-001835-0s7ok4uw	2651	21	models	model	NNS
cord-001835-0s7ok4uw	2651	22	of	of	IN
cord-001835-0s7ok4uw	2651	23	each	each	DT
cord-001835-0s7ok4uw	2651	24	state	state	NN
cord-001835-0s7ok4uw	2651	25	using	use	VBG
cord-001835-0s7ok4uw	2651	26	the	the	DT
cord-001835-0s7ok4uw	2651	27	ROSETTA	ROSETTA	NNP
cord-001835-0s7ok4uw	2651	28	modeling	modeling	NN
cord-001835-0s7ok4uw	2651	29	software	software	NN
cord-001835-0s7ok4uw	2651	30	suite	suite	NN
cord-001835-0s7ok4uw	2651	31	.	.	.
cord-001835-0s7ok4uw	2652	1	Here	here	RB
cord-001835-0s7ok4uw	2652	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2652	3	disseminate	disseminate	VBP
cord-001835-0s7ok4uw	2652	4	a	a	DT
cord-001835-0s7ok4uw	2652	5	comprehensive	comprehensive	JJ
cord-001835-0s7ok4uw	2652	6	analysis	analysis	NN
cord-001835-0s7ok4uw	2652	7	of	of	IN
cord-001835-0s7ok4uw	2652	8	all	all	DT
cord-001835-0s7ok4uw	2652	9	critical	critical	JJ
cord-001835-0s7ok4uw	2652	10	interactions	interaction	NNS
cord-001835-0s7ok4uw	2652	11	and	and	CC
cord-001835-0s7ok4uw	2652	12	create	create	VB
cord-001835-0s7ok4uw	2652	13	intra	intra	JJ
cord-001835-0s7ok4uw	2652	14	-	-	JJ
cord-001835-0s7ok4uw	2652	15	protein	protein	JJ
cord-001835-0s7ok4uw	2652	16	network	network	NN
cord-001835-0s7ok4uw	2652	17	communication	communication	NN
cord-001835-0s7ok4uw	2652	18	maps	map	NNS
cord-001835-0s7ok4uw	2652	19	.	.	.
cord-001835-0s7ok4uw	2653	1	These	these	DT
cord-001835-0s7ok4uw	2653	2	networks	network	NNS
cord-001835-0s7ok4uw	2653	3	represent	represent	VBP
cord-001835-0s7ok4uw	2653	4	nodes	node	NNS
cord-001835-0s7ok4uw	2653	5	of	of	IN
cord-001835-0s7ok4uw	2653	6	interaction	interaction	NN
cord-001835-0s7ok4uw	2653	7	necessary	necessary	JJ
cord-001835-0s7ok4uw	2653	8	for	for	IN
cord-001835-0s7ok4uw	2653	9	G	g	NN
cord-001835-0s7ok4uw	2653	10	protein	protein	NN
cord-001835-0s7ok4uw	2653	11	activation	activation	NN
cord-001835-0s7ok4uw	2653	12	.	.	.
cord-001835-0s7ok4uw	2654	1	Structure	structure	NN
cord-001835-0s7ok4uw	2654	2	and	and	CC
cord-001835-0s7ok4uw	2654	3	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2654	4	of	of	IN
cord-001835-0s7ok4uw	2654	5	the	the	DT
cord-001835-0s7ok4uw	2654	6	polymyxin	polymyxin	NN
cord-001835-0s7ok4uw	2654	7	-	-	HYPH
cord-001835-0s7ok4uw	2654	8	resistance	resistance	NN
cord-001835-0s7ok4uw	2654	9	-	-	HYPH
cord-001835-0s7ok4uw	2654	10	associated	associate	VBN
cord-001835-0s7ok4uw	2654	11	response	response	NN
cord-001835-0s7ok4uw	2654	12	regulator	regulator	NN
cord-001835-0s7ok4uw	2654	13	PmrA	PmrA	NNP
cord-001835-0s7ok4uw	2654	14	in	in	IN
cord-001835-0s7ok4uw	2654	15	complex	complex	NN
cord-001835-0s7ok4uw	2654	16	with	with	IN
cord-001835-0s7ok4uw	2654	17	the	the	DT
cord-001835-0s7ok4uw	2654	18	promoter	promoter	NN
cord-001835-0s7ok4uw	2654	19	DNA	DNA	NNP
cord-001835-0s7ok4uw	2654	20	Yuan	Yuan	NNP
cord-001835-0s7ok4uw	2654	21	-	-	HYPH
cord-001835-0s7ok4uw	2654	22	Chao	Chao	NNP
cord-001835-0s7ok4uw	2654	23	Lou	Lou	NNP
cord-001835-0s7ok4uw	2654	24	1	1	CD
cord-001835-0s7ok4uw	2654	25	,	,	,
cord-001835-0s7ok4uw	2654	26	Yi	Yi	NNP
cord-001835-0s7ok4uw	2654	27	-	-	HYPH
cord-001835-0s7ok4uw	2654	28	Fen	Fen	NNP
cord-001835-0s7ok4uw	2654	29	Kao	Kao	NNP
cord-001835-0s7ok4uw	2654	30	1	1	CD
cord-001835-0s7ok4uw	2654	31	,	,	,
cord-001835-0s7ok4uw	2654	32	Tsi	Tsi	NNP
cord-001835-0s7ok4uw	2654	33	-	-	HYPH
cord-001835-0s7ok4uw	2654	34	Hsuan	Hsuan	NNP
cord-001835-0s7ok4uw	2654	35	Weng	Weng	NNP
cord-001835-0s7ok4uw	2654	36	2	2	CD
cord-001835-0s7ok4uw	2654	37	,	,	,
cord-001835-0s7ok4uw	2654	38	Yi	Yi	NNP
cord-001835-0s7ok4uw	2654	39	-	-	HYPH
cord-001835-0s7ok4uw	2654	40	Chuan	Chuan	NNP
cord-001835-0s7ok4uw	2654	41	Li	Li	NNP
cord-001835-0s7ok4uw	2654	42	2	2	CD
cord-001835-0s7ok4uw	2654	43	,	,	,
cord-001835-0s7ok4uw	2654	44	Chwan	Chwan	NNP
cord-001835-0s7ok4uw	2654	45	-	-	HYPH
cord-001835-0s7ok4uw	2654	46	Deng	Deng	NNP
cord-001835-0s7ok4uw	2654	47	Hsiao	Hsiao	NNP
cord-001835-0s7ok4uw	2654	48	2	2	CD
cord-001835-0s7ok4uw	2654	49	,	,	,
cord-001835-0s7ok4uw	2654	50	Chinpan	Chinpan	NNP
cord-001835-0s7ok4uw	2654	51	Chen	Chen	NNP
cord-001835-0s7ok4uw	2654	52	1	1	CD
cord-001835-0s7ok4uw	2654	53	1	1	CD
cord-001835-0s7ok4uw	2654	54	Institute	Institute	NNP
cord-001835-0s7ok4uw	2654	55	of	of	IN
cord-001835-0s7ok4uw	2654	56	Biomedical	Biomedical	NNP
cord-001835-0s7ok4uw	2654	57	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	2654	58	,	,	,
cord-001835-0s7ok4uw	2654	59	Academia	Academia	NNP
cord-001835-0s7ok4uw	2654	60	Sinica	Sinica	NNP
cord-001835-0s7ok4uw	2654	61	,	,	,
cord-001835-0s7ok4uw	2654	62	2	2	CD
cord-001835-0s7ok4uw	2654	63	Institute	Institute	NNP
cord-001835-0s7ok4uw	2654	64	of	of	IN
cord-001835-0s7ok4uw	2654	65	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	2654	66	Biology	Biology	NNP
cord-001835-0s7ok4uw	2654	67	,	,	,
cord-001835-0s7ok4uw	2654	68	Academia	Academia	NNP
cord-001835-0s7ok4uw	2654	69	Sinica	Sinica	NNP
cord-001835-0s7ok4uw	2654	70	PmrA	PmrA	NNP
cord-001835-0s7ok4uw	2654	71	,	,	,
cord-001835-0s7ok4uw	2654	72	an	an	DT
cord-001835-0s7ok4uw	2654	73	OmpR	OmpR	NNP
cord-001835-0s7ok4uw	2654	74	/	/	SYM
cord-001835-0s7ok4uw	2654	75	PhoB	PhoB	NNP
cord-001835-0s7ok4uw	2654	76	family	family	NN
cord-001835-0s7ok4uw	2654	77	response	response	NN
cord-001835-0s7ok4uw	2654	78	regulator	regulator	NN
cord-001835-0s7ok4uw	2654	79	(	(	-LRB-
cord-001835-0s7ok4uw	2654	80	RR	RR	NNP
cord-001835-0s7ok4uw	2654	81	)	)	-RRB-
cord-001835-0s7ok4uw	2654	82	,	,	,
cord-001835-0s7ok4uw	2654	83	takes	take	VBZ
cord-001835-0s7ok4uw	2654	84	part	part	NN
cord-001835-0s7ok4uw	2654	85	in	in	IN
cord-001835-0s7ok4uw	2654	86	the	the	DT
cord-001835-0s7ok4uw	2654	87	two	two	CD
cord-001835-0s7ok4uw	2654	88	-	-	HYPH
cord-001835-0s7ok4uw	2654	89	component	component	NN
cord-001835-0s7ok4uw	2654	90	system	system	NN
cord-001835-0s7ok4uw	2654	91	that	that	WDT
cord-001835-0s7ok4uw	2654	92	manages	manage	VBZ
cord-001835-0s7ok4uw	2654	93	genes	gene	NNS
cord-001835-0s7ok4uw	2654	94	for	for	IN
cord-001835-0s7ok4uw	2654	95	polymyxin	polymyxin	NN
cord-001835-0s7ok4uw	2654	96	resistance	resistance	NN
cord-001835-0s7ok4uw	2654	97	through	through	IN
cord-001835-0s7ok4uw	2654	98	a	a	DT
cord-001835-0s7ok4uw	2654	99	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	2654	100	-	-	HYPH
cord-001835-0s7ok4uw	2654	101	dependent	dependent	JJ
cord-001835-0s7ok4uw	2654	102	regulation	regulation	NN
cord-001835-0s7ok4uw	2654	103	.	.	.
cord-001835-0s7ok4uw	2655	1	Phosphorylation	Phosphorylation	NNP
cord-001835-0s7ok4uw	2655	2	of	of	IN
cord-001835-0s7ok4uw	2655	3	OmpR/	ompr/	NN
cord-001835-0s7ok4uw	2656	1	PhoB	PhoB	NNP
cord-001835-0s7ok4uw	2656	2	RR	RR	NNP
cord-001835-0s7ok4uw	2656	3	induces	induce	VBZ
cord-001835-0s7ok4uw	2656	4	the	the	DT
cord-001835-0s7ok4uw	2656	5	formation	formation	NN
cord-001835-0s7ok4uw	2656	6	of	of	IN
cord-001835-0s7ok4uw	2656	7	a	a	DT
cord-001835-0s7ok4uw	2656	8	two	two	CD
cord-001835-0s7ok4uw	2656	9	-	-	HYPH
cord-001835-0s7ok4uw	2656	10	fold	fold	JJ
cord-001835-0s7ok4uw	2656	11	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	2656	12	dimer	dimer	NN
cord-001835-0s7ok4uw	2656	13	in	in	IN
cord-001835-0s7ok4uw	2656	14	the	the	DT
cord-001835-0s7ok4uw	2656	15	N	N	NNP
cord-001835-0s7ok4uw	2656	16	-	-	HYPH
cord-001835-0s7ok4uw	2656	17	terminal	terminal	NN
cord-001835-0s7ok4uw	2656	18	receive	receive	VB
cord-001835-0s7ok4uw	2656	19	domain	domain	NN
cord-001835-0s7ok4uw	2656	20	(	(	-LRB-
cord-001835-0s7ok4uw	2656	21	REC	REC	NNP
cord-001835-0s7ok4uw	2656	22	)	)	-RRB-
cord-001835-0s7ok4uw	2656	23	,	,	,
cord-001835-0s7ok4uw	2656	24	promoting	promote	VBG
cord-001835-0s7ok4uw	2656	25	2	2	CD
cord-001835-0s7ok4uw	2656	26	C	c	NN
cord-001835-0s7ok4uw	2656	27	-	-	HYPH
cord-001835-0s7ok4uw	2656	28	terminal	terminal	NN
cord-001835-0s7ok4uw	2656	29	DNA	dna	NN
cord-001835-0s7ok4uw	2656	30	-	-	HYPH
cord-001835-0s7ok4uw	2656	31	binding	bind	VBG
cord-001835-0s7ok4uw	2656	32	domains	domain	NNS
cord-001835-0s7ok4uw	2656	33	(	(	-LRB-
cord-001835-0s7ok4uw	2656	34	DBDs	dbd	NNS
cord-001835-0s7ok4uw	2656	35	)	)	-RRB-
cord-001835-0s7ok4uw	2656	36	to	to	TO
cord-001835-0s7ok4uw	2656	37	recognize	recognize	VB
cord-001835-0s7ok4uw	2656	38	tandem	tandem	JJ
cord-001835-0s7ok4uw	2656	39	repeat	repeat	NN
cord-001835-0s7ok4uw	2656	40	DNA	dna	NN
cord-001835-0s7ok4uw	2656	41	sequences	sequence	NNS
cord-001835-0s7ok4uw	2656	42	on	on	IN
cord-001835-0s7ok4uw	2656	43	the	the	DT
cord-001835-0s7ok4uw	2656	44	promoter	promoter	NN
cord-001835-0s7ok4uw	2656	45	to	to	TO
cord-001835-0s7ok4uw	2656	46	elicit	elicit	VB
cord-001835-0s7ok4uw	2656	47	adaptive	adaptive	JJ
cord-001835-0s7ok4uw	2656	48	responses	response	NNS
cord-001835-0s7ok4uw	2656	49	.	.	.
cord-001835-0s7ok4uw	2657	1	Recently	recently	RB
cord-001835-0s7ok4uw	2657	2	,	,	,
cord-001835-0s7ok4uw	2657	3	Narayanan	Narayanan	NNP
cord-001835-0s7ok4uw	2657	4	et	et	NNP
cord-001835-0s7ok4uw	2657	5	al	al	NNP
cord-001835-0s7ok4uw	2657	6	.	.	.
cord-001835-0s7ok4uw	2658	1	presented	present	VBD
cord-001835-0s7ok4uw	2658	2	the	the	DT
cord-001835-0s7ok4uw	2658	3	complex	complex	JJ
cord-001835-0s7ok4uw	2658	4	structure	structure	NN
cord-001835-0s7ok4uw	2658	5	of	of	IN
cord-001835-0s7ok4uw	2658	6	active	active	JJ
cord-001835-0s7ok4uw	2658	7	-	-	HYPH
cord-001835-0s7ok4uw	2658	8	like	like	JJ
cord-001835-0s7ok4uw	2658	9	KdpE	KdpE	NNP
cord-001835-0s7ok4uw	2658	10	in	in	IN
cord-001835-0s7ok4uw	2658	11	complex	complex	NN
cord-001835-0s7ok4uw	2658	12	with	with	IN
cord-001835-0s7ok4uw	2658	13	DNA	dna	NN
cord-001835-0s7ok4uw	2658	14	,	,	,
cord-001835-0s7ok4uw	2658	15	which	which	WDT
cord-001835-0s7ok4uw	2658	16	reveals	reveal	VBZ
cord-001835-0s7ok4uw	2658	17	a	a	DT
cord-001835-0s7ok4uw	2658	18	unique	unique	JJ
cord-001835-0s7ok4uw	2658	19	asymmetric	asymmetric	JJ
cord-001835-0s7ok4uw	2658	20	REC	REC	NNP
cord-001835-0s7ok4uw	2658	21	-	-	HYPH
cord-001835-0s7ok4uw	2658	22	DBD	DBD	NNP
cord-001835-0s7ok4uw	2658	23	interface	interface	NN
cord-001835-0s7ok4uw	2658	24	that	that	WDT
cord-001835-0s7ok4uw	2658	25	is	be	VBZ
cord-001835-0s7ok4uw	2658	26	necessary	necessary	JJ
cord-001835-0s7ok4uw	2658	27	to	to	TO
cord-001835-0s7ok4uw	2658	28	form	form	VB
cord-001835-0s7ok4uw	2658	29	stable	stable	JJ
cord-001835-0s7ok4uw	2658	30	complexes	complex	NNS
cord-001835-0s7ok4uw	2658	31	for	for	IN
cord-001835-0s7ok4uw	2658	32	transcription	transcription	NN
cord-001835-0s7ok4uw	2658	33	activation	activation	NN
cord-001835-0s7ok4uw	2658	34	.	.	.
cord-001835-0s7ok4uw	2659	1	In	in	IN
cord-001835-0s7ok4uw	2659	2	this	this	DT
cord-001835-0s7ok4uw	2659	3	study	study	NN
cord-001835-0s7ok4uw	2659	4	,	,	,
cord-001835-0s7ok4uw	2659	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2659	6	report	report	VBP
cord-001835-0s7ok4uw	2659	7	the	the	DT
cord-001835-0s7ok4uw	2659	8	3.2	3.2	CD
cord-001835-0s7ok4uw	2659	9	Å	å	NN
cord-001835-0s7ok4uw	2659	10	resolution	resolution	NN
cord-001835-0s7ok4uw	2659	11	crystal	crystal	NN
cord-001835-0s7ok4uw	2659	12	structure	structure	NN
cord-001835-0s7ok4uw	2659	13	of	of	IN
cord-001835-0s7ok4uw	2659	14	BeF3-activated	BeF3-activated	NNP
cord-001835-0s7ok4uw	2659	15	PmrA	PmrA	NNP
cord-001835-0s7ok4uw	2659	16	in	in	IN
cord-001835-0s7ok4uw	2659	17	complex	complex	NN
cord-001835-0s7ok4uw	2659	18	with	with	IN
cord-001835-0s7ok4uw	2659	19	promoter	promoter	NN
cord-001835-0s7ok4uw	2659	20	DNA	dna	NN
cord-001835-0s7ok4uw	2659	21	as	as	RB
cord-001835-0s7ok4uw	2659	22	well	well	RB
cord-001835-0s7ok4uw	2659	23	as	as	IN
cord-001835-0s7ok4uw	2659	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2659	25	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2659	26	in	in	IN
cord-001835-0s7ok4uw	2659	27	solution	solution	NN
cord-001835-0s7ok4uw	2659	28	by	by	IN
cord-001835-0s7ok4uw	2659	29	NMR	NMR	NNP
cord-001835-0s7ok4uw	2659	30	.	.	.
cord-001835-0s7ok4uw	2660	1	Unlike	unlike	IN
cord-001835-0s7ok4uw	2660	2	the	the	DT
cord-001835-0s7ok4uw	2660	3	case	case	NN
cord-001835-0s7ok4uw	2660	4	of	of	IN
cord-001835-0s7ok4uw	2660	5	KdpE	KdpE	NNP
cord-001835-0s7ok4uw	2660	6	,	,	,
cord-001835-0s7ok4uw	2660	7	PmrA	PmrA	NNP
cord-001835-0s7ok4uw	2660	8	-	-	HYPH
cord-001835-0s7ok4uw	2660	9	DNA	dna	NN
cord-001835-0s7ok4uw	2660	10	complex	complex	JJ
cord-001835-0s7ok4uw	2660	11	structure	structure	NN
cord-001835-0s7ok4uw	2660	12	reveals	reveal	VBZ
cord-001835-0s7ok4uw	2660	13	a	a	DT
cord-001835-0s7ok4uw	2660	14	different	different	JJ
cord-001835-0s7ok4uw	2660	15	asymmetric	asymmetric	JJ
cord-001835-0s7ok4uw	2660	16	REC	REC	NNP
cord-001835-0s7ok4uw	2660	17	-	-	HYPH
cord-001835-0s7ok4uw	2660	18	DBD	DBD	NNP
cord-001835-0s7ok4uw	2660	19	interaction	interaction	NN
cord-001835-0s7ok4uw	2660	20	.	.	.
cord-001835-0s7ok4uw	2661	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	2661	2	,	,	,
cord-001835-0s7ok4uw	2661	3	NMR	NMR	NNP
cord-001835-0s7ok4uw	2661	4	assignments	assignment	NNS
cord-001835-0s7ok4uw	2661	5	and	and	CC
cord-001835-0s7ok4uw	2661	6	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2661	7	study	study	NN
cord-001835-0s7ok4uw	2661	8	suggest	suggest	VBP
cord-001835-0s7ok4uw	2661	9	that	that	IN
cord-001835-0s7ok4uw	2661	10	REC	REC	NNP
cord-001835-0s7ok4uw	2661	11	and	and	CC
cord-001835-0s7ok4uw	2661	12	DBD	DBD	NNP
cord-001835-0s7ok4uw	2661	13	do	do	VBP
cord-001835-0s7ok4uw	2661	14	not	not	RB
cord-001835-0s7ok4uw	2661	15	form	form	VB
cord-001835-0s7ok4uw	2661	16	stable	stable	JJ
cord-001835-0s7ok4uw	2661	17	contacts	contact	NNS
cord-001835-0s7ok4uw	2661	18	in	in	IN
cord-001835-0s7ok4uw	2661	19	solution	solution	NN
cord-001835-0s7ok4uw	2661	20	;	;	:
cord-001835-0s7ok4uw	2661	21	instead	instead	RB
cord-001835-0s7ok4uw	2661	22	,	,	,
cord-001835-0s7ok4uw	2661	23	2	2	CD
cord-001835-0s7ok4uw	2661	24	domains	domain	NNS
cord-001835-0s7ok4uw	2661	25	tumble	tumble	VBP
cord-001835-0s7ok4uw	2661	26	separately	separately	RB
cord-001835-0s7ok4uw	2661	27	in	in	IN
cord-001835-0s7ok4uw	2661	28	the	the	DT
cord-001835-0s7ok4uw	2661	29	absence	absence	NN
cord-001835-0s7ok4uw	2661	30	or	or	CC
cord-001835-0s7ok4uw	2661	31	presence	presence	NN
cord-001835-0s7ok4uw	2661	32	of	of	IN
cord-001835-0s7ok4uw	2661	33	DNA	DNA	NNP
cord-001835-0s7ok4uw	2661	34	.	.	.
cord-001835-0s7ok4uw	2662	1	Relaxation	relaxation	NN
cord-001835-0s7ok4uw	2662	2	dispersion	dispersion	NN
cord-001835-0s7ok4uw	2662	3	experiments	experiment	NNS
cord-001835-0s7ok4uw	2662	4	on	on	IN
cord-001835-0s7ok4uw	2662	5	methyl	methyl	NN
cord-001835-0s7ok4uw	2662	6	groups	group	NNS
cord-001835-0s7ok4uw	2662	7	further	far	RBR
cord-001835-0s7ok4uw	2662	8	show	show	VBP
cord-001835-0s7ok4uw	2662	9	that	that	IN
cord-001835-0s7ok4uw	2662	10	several	several	JJ
cord-001835-0s7ok4uw	2662	11	REC	REC	NNP
cord-001835-0s7ok4uw	2662	12	-	-	HYPH
cord-001835-0s7ok4uw	2662	13	DBD	DBD	NNP
cord-001835-0s7ok4uw	2662	14	interfacial	interfacial	JJ
cord-001835-0s7ok4uw	2662	15	residues	residue	NNS
cord-001835-0s7ok4uw	2662	16	exhibit	exhibit	VBP
cord-001835-0s7ok4uw	2662	17	similar	similar	JJ
cord-001835-0s7ok4uw	2662	18	slow	slow	JJ
cord-001835-0s7ok4uw	2662	19	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2662	20	in	in	IN
cord-001835-0s7ok4uw	2662	21	the	the	DT
cord-001835-0s7ok4uw	2662	22	presence	presence	NN
cord-001835-0s7ok4uw	2662	23	of	of	IN
cord-001835-0s7ok4uw	2662	24	DNA	DNA	NNP
cord-001835-0s7ok4uw	2662	25	.	.	.
cord-001835-0s7ok4uw	2663	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2663	2	is	be	VBZ
cord-001835-0s7ok4uw	2663	3	hence	hence	RB
cord-001835-0s7ok4uw	2663	4	highly	highly	RB
cord-001835-0s7ok4uw	2663	5	possible	possible	JJ
cord-001835-0s7ok4uw	2663	6	that	that	IN
cord-001835-0s7ok4uw	2663	7	the	the	DT
cord-001835-0s7ok4uw	2663	8	slow	slow	JJ
cord-001835-0s7ok4uw	2663	9	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2663	10	observed	observe	VBN
cord-001835-0s7ok4uw	2663	11	on	on	IN
cord-001835-0s7ok4uw	2663	12	these	these	DT
cord-001835-0s7ok4uw	2663	13	interfacial	interfacial	JJ
cord-001835-0s7ok4uw	2663	14	methyl	methyl	NN
cord-001835-0s7ok4uw	2663	15	groups	group	NNS
cord-001835-0s7ok4uw	2663	16	are	be	VBP
cord-001835-0s7ok4uw	2663	17	related	relate	VBN
cord-001835-0s7ok4uw	2663	18	to	to	IN
cord-001835-0s7ok4uw	2663	19	the	the	DT
cord-001835-0s7ok4uw	2663	20	formation	formation	NN
cord-001835-0s7ok4uw	2663	21	of	of	IN
cord-001835-0s7ok4uw	2663	22	asymmetric	asymmetric	JJ
cord-001835-0s7ok4uw	2663	23	REC	REC	NNP
cord-001835-0s7ok4uw	2663	24	-	-	HYPH
cord-001835-0s7ok4uw	2663	25	DBD	DBD	NNP
cord-001835-0s7ok4uw	2663	26	interaction	interaction	NN
cord-001835-0s7ok4uw	2663	27	,	,	,
cord-001835-0s7ok4uw	2663	28	which	which	WDT
cord-001835-0s7ok4uw	2663	29	reduces	reduce	VBZ
cord-001835-0s7ok4uw	2663	30	the	the	DT
cord-001835-0s7ok4uw	2663	31	mobility	mobility	NN
cord-001835-0s7ok4uw	2663	32	of	of	IN
cord-001835-0s7ok4uw	2663	33	PmrA	PmrA	NNP
cord-001835-0s7ok4uw	2663	34	-	-	HYPH
cord-001835-0s7ok4uw	2663	35	DNA	dna	NN
cord-001835-0s7ok4uw	2663	36	complex	complex	NN
cord-001835-0s7ok4uw	2663	37	and	and	CC
cord-001835-0s7ok4uw	2663	38	promotes	promote	VBZ
cord-001835-0s7ok4uw	2663	39	crystallization	crystallization	NN
cord-001835-0s7ok4uw	2663	40	.	.	.
cord-001835-0s7ok4uw	2664	1	In	in	IN
cord-001835-0s7ok4uw	2664	2	solution	solution	NN
cord-001835-0s7ok4uw	2664	3	,	,	,
cord-001835-0s7ok4uw	2664	4	two	two	CD
cord-001835-0s7ok4uw	2664	5	domains	domain	NNS
cord-001835-0s7ok4uw	2664	6	tumble	tumble	VBP
cord-001835-0s7ok4uw	2664	7	independently	independently	RB
cord-001835-0s7ok4uw	2664	8	and	and	CC
cord-001835-0s7ok4uw	2664	9	have	have	VBP
cord-001835-0s7ok4uw	2664	10	diverse	diverse	JJ
cord-001835-0s7ok4uw	2664	11	orientations	orientation	NNS
cord-001835-0s7ok4uw	2664	12	,	,	,
cord-001835-0s7ok4uw	2664	13	which	which	WDT
cord-001835-0s7ok4uw	2664	14	together	together	RB
cord-001835-0s7ok4uw	2664	15	with	with	IN
cord-001835-0s7ok4uw	2664	16	the	the	DT
cord-001835-0s7ok4uw	2664	17	DBD	DBD	NNP
cord-001835-0s7ok4uw	2664	18	-	-	HYPH
cord-001835-0s7ok4uw	2664	19	DBD	DBD	NNP
cord-001835-0s7ok4uw	2664	20	interface	interface	NN
cord-001835-0s7ok4uw	2664	21	may	may	MD
cord-001835-0s7ok4uw	2664	22	facilitate	facilitate	VB
cord-001835-0s7ok4uw	2664	23	searching	search	VBG
cord-001835-0s7ok4uw	2664	24	best	good	JJS
cord-001835-0s7ok4uw	2664	25	interactions	interaction	NNS
cord-001835-0s7ok4uw	2664	26	with	with	IN
cord-001835-0s7ok4uw	2664	27	RNA	RNA	NNP
cord-001835-0s7ok4uw	2664	28	polymerase	polymerase	NN
cord-001835-0s7ok4uw	2664	29	holoenzyme	holoenzyme	NNS
cord-001835-0s7ok4uw	2664	30	for	for	IN
cord-001835-0s7ok4uw	2664	31	transcription	transcription	NN
cord-001835-0s7ok4uw	2664	32	activation	activation	NN
cord-001835-0s7ok4uw	2664	33	.	.	.
cord-001835-0s7ok4uw	2665	1	Time	time	NN
cord-001835-0s7ok4uw	2665	2	-	-	HYPH
cord-001835-0s7ok4uw	2665	3	resolved	resolve	VBN
cord-001835-0s7ok4uw	2665	4	X	x	NN
cord-001835-0s7ok4uw	2665	5	-	-	NN
cord-001835-0s7ok4uw	2665	6	ray	ray	NN
cord-001835-0s7ok4uw	2665	7	Observations	observation	NNS
cord-001835-0s7ok4uw	2665	8	of	of	IN
cord-001835-0s7ok4uw	2665	9	Nano	Nano	NNP
cord-001835-0s7ok4uw	2665	10	-	-	HYPH
cord-001835-0s7ok4uw	2665	11	scale	scale	NN
cord-001835-0s7ok4uw	2665	12	Protein	Protein	NNP
cord-001835-0s7ok4uw	2665	13	Assembly	Assembly	NNP
cord-001835-0s7ok4uw	2665	14	Networks	Networks	NNP
cord-001835-0s7ok4uw	2665	15	Yufuku	Yufuku	NNP
cord-001835-0s7ok4uw	2665	16	Matsushita	Matsushita	NNP
cord-001835-0s7ok4uw	2665	17	1	1	CD
cord-001835-0s7ok4uw	2665	18	,	,	,
cord-001835-0s7ok4uw	2665	19	Hiroshi	Hiroshi	NNP
cord-001835-0s7ok4uw	2665	20	Sekiguchi	Sekiguchi	NNP
cord-001835-0s7ok4uw	2665	21	2	2	CD
cord-001835-0s7ok4uw	2665	22	,	,	,
cord-001835-0s7ok4uw	2665	23	Noboru	Noboru	NNP
cord-001835-0s7ok4uw	2665	24	Ohta	Ohta	NNP
cord-001835-0s7ok4uw	2665	25	2	2	CD
cord-001835-0s7ok4uw	2665	26	,	,	,
cord-001835-0s7ok4uw	2665	27	Keigo	Keigo	NNP
cord-001835-0s7ok4uw	2665	28	Ikezaki	Ikezaki	NNP
cord-001835-0s7ok4uw	2665	29	1	1	CD
cord-001835-0s7ok4uw	2665	30	,	,	,
cord-001835-0s7ok4uw	2665	31	Yuji	Yuji	NNP
cord-001835-0s7ok4uw	2665	32	Goto	Goto	NNP
cord-001835-0s7ok4uw	2665	33	3	3	CD
cord-001835-0s7ok4uw	2665	34	,	,	,
cord-001835-0s7ok4uw	2665	35	Yuji	Yuji	NNP
cord-001835-0s7ok4uw	2665	36	Sasaki	Sasaki	NNP
cord-001835-0s7ok4uw	2665	37	1,3	1,3	CD
cord-001835-0s7ok4uw	2665	38	1	1	CD
cord-001835-0s7ok4uw	2666	1	The	the	DT
cord-001835-0s7ok4uw	2666	2	University	University	NNP
cord-001835-0s7ok4uw	2666	3	of	of	IN
cord-001835-0s7ok4uw	2666	4	Tokyo	Tokyo	NNP
cord-001835-0s7ok4uw	2666	5	,	,	,
cord-001835-0s7ok4uw	2666	6	Graduate	Graduate	NNP
cord-001835-0s7ok4uw	2666	7	School	School	NNP
cord-001835-0s7ok4uw	2666	8	of	of	IN
cord-001835-0s7ok4uw	2666	9	Frontier	Frontier	NNP
cord-001835-0s7ok4uw	2666	10	Science	Science	NNP
cord-001835-0s7ok4uw	2666	11	,	,	,
cord-001835-0s7ok4uw	2666	12	Advanced	Advanced	NNP
cord-001835-0s7ok4uw	2666	13	Materials	Materials	NNPS
cord-001835-0s7ok4uw	2666	14	Science	Science	NNP
cord-001835-0s7ok4uw	2666	15	,	,	,
cord-001835-0s7ok4uw	2666	16	2	2	CD
cord-001835-0s7ok4uw	2666	17	SPring-8	spring-8	NN
cord-001835-0s7ok4uw	2666	18	,	,	,
cord-001835-0s7ok4uw	2666	19	3	3	CD
cord-001835-0s7ok4uw	2666	20	Osaka	Osaka	NNP
cord-001835-0s7ok4uw	2666	21	University	University	NNP
cord-001835-0s7ok4uw	2666	22	,	,	,
cord-001835-0s7ok4uw	2666	23	Institute	Institute	NNP
cord-001835-0s7ok4uw	2666	24	For	for	IN
cord-001835-0s7ok4uw	2666	25	Protein	Protein	NNP
cord-001835-0s7ok4uw	2666	26	Research	Research	NNP
cord-001835-0s7ok4uw	2666	27	Protein	Protein	NNP
cord-001835-0s7ok4uw	2666	28	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2666	29	and	and	CC
cord-001835-0s7ok4uw	2666	30	network	network	NN
cord-001835-0s7ok4uw	2666	31	formation	formation	NN
cord-001835-0s7ok4uw	2666	32	in	in	IN
cord-001835-0s7ok4uw	2666	33	diverse	diverse	JJ
cord-001835-0s7ok4uw	2666	34	protein	protein	NN
cord-001835-0s7ok4uw	2666	35	species	specie	NNS
cord-001835-0s7ok4uw	2666	36	had	have	VBD
cord-001835-0s7ok4uw	2666	37	been	be	VBN
cord-001835-0s7ok4uw	2666	38	studying	study	VBG
cord-001835-0s7ok4uw	2666	39	in	in	IN
cord-001835-0s7ok4uw	2666	40	various	various	JJ
cord-001835-0s7ok4uw	2666	41	experimental	experimental	JJ
cord-001835-0s7ok4uw	2666	42	approaches	approach	NNS
cord-001835-0s7ok4uw	2666	43	such	such	JJ
cord-001835-0s7ok4uw	2666	44	as	as	IN
cord-001835-0s7ok4uw	2666	45	absorbance	absorbance	NN
cord-001835-0s7ok4uw	2666	46	spectrophotometry	spectrophotometry	NN
cord-001835-0s7ok4uw	2666	47	,	,	,
cord-001835-0s7ok4uw	2666	48	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	2666	49	light	light	NN
cord-001835-0s7ok4uw	2666	50	scattering	scattering	NN
cord-001835-0s7ok4uw	2666	51	and	and	CC
cord-001835-0s7ok4uw	2666	52	X	x	NN
cord-001835-0s7ok4uw	2666	53	-	-	NN
cord-001835-0s7ok4uw	2666	54	ray	ray	NN
cord-001835-0s7ok4uw	2666	55	scattering	scattering	NN
cord-001835-0s7ok4uw	2666	56	.	.	.
cord-001835-0s7ok4uw	2667	1	However	however	RB
cord-001835-0s7ok4uw	2667	2	,	,	,
cord-001835-0s7ok4uw	2667	3	these	these	DT
cord-001835-0s7ok4uw	2667	4	conventional	conventional	JJ
cord-001835-0s7ok4uw	2667	5	methods	method	NNS
cord-001835-0s7ok4uw	2667	6	are	be	VBP
cord-001835-0s7ok4uw	2667	7	only	only	RB
cord-001835-0s7ok4uw	2667	8	able	able	JJ
cord-001835-0s7ok4uw	2667	9	to	to	TO
cord-001835-0s7ok4uw	2667	10	observe	observe	VB
cord-001835-0s7ok4uw	2667	11	averaged	average	VBN
cord-001835-0s7ok4uw	2667	12	information	information	NN
cord-001835-0s7ok4uw	2667	13	on	on	IN
cord-001835-0s7ok4uw	2667	14	bulk	bulk	JJ
cord-001835-0s7ok4uw	2667	15	conditions	condition	NNS
cord-001835-0s7ok4uw	2667	16	and	and	CC
cord-001835-0s7ok4uw	2667	17	also	also	RB
cord-001835-0s7ok4uw	2667	18	these	these	DT
cord-001835-0s7ok4uw	2667	19	techniques	technique	NNS
cord-001835-0s7ok4uw	2667	20	have	have	VBP
cord-001835-0s7ok4uw	2667	21	a	a	DT
cord-001835-0s7ok4uw	2667	22	limitation	limitation	NN
cord-001835-0s7ok4uw	2667	23	of	of	IN
cord-001835-0s7ok4uw	2667	24	time	time	NN
cord-001835-0s7ok4uw	2667	25	resolved	resolve	VBD
cord-001835-0s7ok4uw	2667	26	observations	observation	NNS
cord-001835-0s7ok4uw	2667	27	.	.	.
cord-001835-0s7ok4uw	2668	1	Recently	recently	RB
cord-001835-0s7ok4uw	2668	2	,	,	,
cord-001835-0s7ok4uw	2668	3	development	development	NN
cord-001835-0s7ok4uw	2668	4	of	of	IN
cord-001835-0s7ok4uw	2668	5	single	single	JJ
cord-001835-0s7ok4uw	2668	6	molecular	molecular	JJ
cord-001835-0s7ok4uw	2668	7	observation	observation	NN
cord-001835-0s7ok4uw	2668	8	techniques	technique	NNS
cord-001835-0s7ok4uw	2668	9	are	be	VBP
cord-001835-0s7ok4uw	2668	10	remarkable	remarkable	JJ
cord-001835-0s7ok4uw	2668	11	.	.	.
cord-001835-0s7ok4uw	2669	1	Diffracted	Diffracted	NNP
cord-001835-0s7ok4uw	2669	2	X	x	NN
cord-001835-0s7ok4uw	2669	3	-	-	NN
cord-001835-0s7ok4uw	2669	4	ray	ray	NN
cord-001835-0s7ok4uw	2669	5	Tracking	tracking	NN
cord-001835-0s7ok4uw	2669	6	(	(	-LRB-
cord-001835-0s7ok4uw	2669	7	DXT	DXT	NNP
cord-001835-0s7ok4uw	2669	8	)	)	-RRB-
cord-001835-0s7ok4uw	2669	9	is	be	VBZ
cord-001835-0s7ok4uw	2669	10	one	one	CD
cord-001835-0s7ok4uw	2669	11	of	of	IN
cord-001835-0s7ok4uw	2669	12	the	the	DT
cord-001835-0s7ok4uw	2669	13	notable	notable	JJ
cord-001835-0s7ok4uw	2669	14	single	single	JJ
cord-001835-0s7ok4uw	2669	15	molecular	molecular	JJ
cord-001835-0s7ok4uw	2669	16	observation	observation	NN
cord-001835-0s7ok4uw	2669	17	methods	method	NNS
cord-001835-0s7ok4uw	2669	18	to	to	TO
cord-001835-0s7ok4uw	2669	19	capture	capture	VB
cord-001835-0s7ok4uw	2669	20	detailed	detailed	JJ
cord-001835-0s7ok4uw	2669	21	intramolecular	intramolecular	JJ
cord-001835-0s7ok4uw	2669	22	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2669	23	of	of	IN
cord-001835-0s7ok4uw	2669	24	an	an	DT
cord-001835-0s7ok4uw	2669	25	individual	individual	JJ
cord-001835-0s7ok4uw	2669	26	single	single	JJ
cord-001835-0s7ok4uw	2669	27	protein	protein	NN
cord-001835-0s7ok4uw	2669	28	molecule	molecule	NN
cord-001835-0s7ok4uw	2669	29	by	by	IN
cord-001835-0s7ok4uw	2669	30	the	the	DT
cord-001835-0s7ok4uw	2669	31	labeling	labeling	NN
cord-001835-0s7ok4uw	2669	32	X	x	NN
cord-001835-0s7ok4uw	2669	33	-	-	NN
cord-001835-0s7ok4uw	2669	34	ray	ray	NN
cord-001835-0s7ok4uw	2669	35	method	method	NN
cord-001835-0s7ok4uw	2669	36	.	.	.
cord-001835-0s7ok4uw	2670	1	In	in	IN
cord-001835-0s7ok4uw	2670	2	this	this	DT
cord-001835-0s7ok4uw	2670	3	study	study	NN
cord-001835-0s7ok4uw	2670	4	,	,	,
cord-001835-0s7ok4uw	2670	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2670	6	present	present	VBP
cord-001835-0s7ok4uw	2670	7	an	an	DT
cord-001835-0s7ok4uw	2670	8	innovative	innovative	JJ
cord-001835-0s7ok4uw	2670	9	method	method	NN
cord-001835-0s7ok4uw	2670	10	for	for	IN
cord-001835-0s7ok4uw	2670	11	observing	observe	VBG
cord-001835-0s7ok4uw	2670	12	the	the	DT
cord-001835-0s7ok4uw	2670	13	protein	protein	NN
cord-001835-0s7ok4uw	2670	14	assembly	assembly	NN
cord-001835-0s7ok4uw	2670	15	networks	network	NNS
cord-001835-0s7ok4uw	2670	16	of	of	IN
cord-001835-0s7ok4uw	2670	17	nano	nano	NN
cord-001835-0s7ok4uw	2670	18	-	-	HYPH
cord-001835-0s7ok4uw	2670	19	scale	scale	NN
cord-001835-0s7ok4uw	2670	20	size	size	NN
cord-001835-0s7ok4uw	2670	21	on	on	IN
cord-001835-0s7ok4uw	2670	22	the	the	DT
cord-001835-0s7ok4uw	2670	23	bulk	bulk	JJ
cord-001835-0s7ok4uw	2670	24	solution	solution	NN
cord-001835-0s7ok4uw	2670	25	using	use	VBG
cord-001835-0s7ok4uw	2670	26	a	a	DT
cord-001835-0s7ok4uw	2670	27	DXT	dxt	NN
cord-001835-0s7ok4uw	2670	28	that	that	WDT
cord-001835-0s7ok4uw	2670	29	possess	possess	VBP
cord-001835-0s7ok4uw	2670	30	pico	pico	NN
cord-001835-0s7ok4uw	2670	31	-	-	HYPH
cord-001835-0s7ok4uw	2670	32	meter	meter	NN
cord-001835-0s7ok4uw	2670	33	scale	scale	NN
cord-001835-0s7ok4uw	2670	34	positional	positional	JJ
cord-001835-0s7ok4uw	2670	35	accuracy	accuracy	NN
cord-001835-0s7ok4uw	2670	36	and	and	CC
cord-001835-0s7ok4uw	2670	37	micro	micro	JJ
cord-001835-0s7ok4uw	2670	38	-	-	JJ
cord-001835-0s7ok4uw	2670	39	second	second	JJ
cord-001835-0s7ok4uw	2670	40	time	time	NN
cord-001835-0s7ok4uw	2670	41	resolution	resolution	NN
cord-001835-0s7ok4uw	2670	42	.	.	.
cord-001835-0s7ok4uw	2671	1	This	this	DT
cord-001835-0s7ok4uw	2671	2	method	method	NN
cord-001835-0s7ok4uw	2671	3	is	be	VBZ
cord-001835-0s7ok4uw	2671	4	founded	found	VBN
cord-001835-0s7ok4uw	2671	5	by	by	IN
cord-001835-0s7ok4uw	2671	6	detecting	detect	VBG
cord-001835-0s7ok4uw	2671	7	angular	angular	JJ
cord-001835-0s7ok4uw	2671	8	rotational	rotational	JJ
cord-001835-0s7ok4uw	2671	9	displacement	displacement	NN
cord-001835-0s7ok4uw	2671	10	of	of	IN
cord-001835-0s7ok4uw	2671	11	a	a	DT
cord-001835-0s7ok4uw	2671	12	coexisted	coexist	VBN
cord-001835-0s7ok4uw	2671	13	and	and	CC
cord-001835-0s7ok4uw	2671	14	dispersed	disperse	VBN
cord-001835-0s7ok4uw	2671	15	single	single	JJ
cord-001835-0s7ok4uw	2671	16	gold	gold	NN
cord-001835-0s7ok4uw	2671	17	nanocrystal	nanocrystal	NN
cord-001835-0s7ok4uw	2671	18	(	(	-LRB-
cord-001835-0s7ok4uw	2671	19	approximately	approximately	RB
cord-001835-0s7ok4uw	2671	20	100	100	CD
cord-001835-0s7ok4uw	2671	21	nm	nm	CD
cord-001835-0s7ok4uw	2671	22	)	)	-RRB-
cord-001835-0s7ok4uw	2671	23	on	on	IN
cord-001835-0s7ok4uw	2671	24	target	target	NN
cord-001835-0s7ok4uw	2671	25	solution	solution	NN
cord-001835-0s7ok4uw	2671	26	.	.	.
cord-001835-0s7ok4uw	2672	1	For	for	IN
cord-001835-0s7ok4uw	2672	2	target	target	NN
cord-001835-0s7ok4uw	2672	3	sample	sample	NN
cord-001835-0s7ok4uw	2672	4	,	,	,
cord-001835-0s7ok4uw	2672	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2672	6	choose	choose	VBP
cord-001835-0s7ok4uw	2672	7	a	a	DT
cord-001835-0s7ok4uw	2672	8	crystal	crystal	NN
cord-001835-0s7ok4uw	2672	9	precursor	precursor	NN
cord-001835-0s7ok4uw	2672	10	metastable	metastable	JJ
cord-001835-0s7ok4uw	2672	11	state	state	NN
cord-001835-0s7ok4uw	2672	12	of	of	IN
cord-001835-0s7ok4uw	2672	13	20	20	CD
cord-001835-0s7ok4uw	2672	14	mg	mg	NNP
cord-001835-0s7ok4uw	2672	15	/	/	SYM
cord-001835-0s7ok4uw	2672	16	ml	ml	NN
cord-001835-0s7ok4uw	2672	17	lysozyme	lysozyme	NN
cord-001835-0s7ok4uw	2672	18	solution	solution	NN
cord-001835-0s7ok4uw	2672	19	(	(	-LRB-
cord-001835-0s7ok4uw	2672	20	Hen	Hen	NNP
cord-001835-0s7ok4uw	2672	21	egg	egg	NN
cord-001835-0s7ok4uw	2672	22	white	white	JJ
cord-001835-0s7ok4uw	2672	23	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	2672	24	:	:	:
cord-001835-0s7ok4uw	2672	25	14331.20	14331.20	CD
cord-001835-0s7ok4uw	2672	26	g/	g/	JJ
cord-001835-0s7ok4uw	2672	27	mole	mole	NN
cord-001835-0s7ok4uw	2672	28	on	on	IN
cord-001835-0s7ok4uw	2672	29	0.2	0.2	CD
cord-001835-0s7ok4uw	2672	30	M	m	NN
cord-001835-0s7ok4uw	2672	31	sodium	sodium	NN
cord-001835-0s7ok4uw	2672	32	acetate	acetate	NN
cord-001835-0s7ok4uw	2672	33	3	3	CD
cord-001835-0s7ok4uw	2672	34	-4	-4	NNP
cord-001835-0s7ok4uw	2672	35	w	w	NN
cord-001835-0s7ok4uw	2672	36	/	/	SYM
cord-001835-0s7ok4uw	2672	37	v	v	NN
cord-001835-0s7ok4uw	2672	38	NaCl	NaCl	NNP
cord-001835-0s7ok4uw	2672	39	,	,	,
cord-001835-0s7ok4uw	2672	40	pH	ph	NN
cord-001835-0s7ok4uw	2672	41	4.7	4.7	CD
cord-001835-0s7ok4uw	2672	42	buffer	buffer	NN
cord-001835-0s7ok4uw	2672	43	)	)	-RRB-
cord-001835-0s7ok4uw	2673	1	and	and	CC
cord-001835-0s7ok4uw	2673	2	10	10	CD
cord-001835-0s7ok4uw	2673	3	mg	mg	NNP
cord-001835-0s7ok4uw	2673	4	/	/	SYM
cord-001835-0s7ok4uw	2673	5	ml	ml	NN
cord-001835-0s7ok4uw	2673	6	of	of	IN
cord-001835-0s7ok4uw	2673	7	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	2673	8	solution	solution	NN
cord-001835-0s7ok4uw	2673	9	such	such	JJ
cord-001835-0s7ok4uw	2673	10	as	as	IN
cord-001835-0s7ok4uw	2673	11	stable	stable	JJ
cord-001835-0s7ok4uw	2673	12	condition	condition	NN
cord-001835-0s7ok4uw	2673	13	.	.	.
cord-001835-0s7ok4uw	2674	1	For	for	IN
cord-001835-0s7ok4uw	2674	2	reference	reference	NN
cord-001835-0s7ok4uw	2674	3	sample	sample	NN
cord-001835-0s7ok4uw	2674	4	,	,	,
cord-001835-0s7ok4uw	2674	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2674	6	prepare	prepare	VBP
cord-001835-0s7ok4uw	2674	7	20	20	CD
cord-001835-0s7ok4uw	2674	8	mg	mg	NNP
cord-001835-0s7ok4uw	2674	9	/	/	SYM
cord-001835-0s7ok4uw	2674	10	ml	ml	NN
cord-001835-0s7ok4uw	2674	11	and	and	CC
cord-001835-0s7ok4uw	2674	12	10	10	CD
cord-001835-0s7ok4uw	2674	13	mg	mg	NNP
cord-001835-0s7ok4uw	2674	14	/	/	SYM
cord-001835-0s7ok4uw	2674	15	ml	ml	NN
cord-001835-0s7ok4uw	2674	16	of	of	IN
cord-001835-0s7ok4uw	2675	1	ribonuclease	ribonuclease	NN
cord-001835-0s7ok4uw	2675	2	A	a	DT
cord-001835-0s7ok4uw	2675	3	solution	solution	NN
cord-001835-0s7ok4uw	2675	4	(	(	-LRB-
cord-001835-0s7ok4uw	2675	5	Ribonuclease	Ribonuclease	NNP
cord-001835-0s7ok4uw	2675	6	A	A	NNP
cord-001835-0s7ok4uw	2675	7	(	(	-LRB-
cord-001835-0s7ok4uw	2675	8	Bovine	bovine	NN
cord-001835-0s7ok4uw	2675	9	)	)	-RRB-
cord-001835-0s7ok4uw	2675	10	:	:	:
cord-001835-0s7ok4uw	2676	1	13708.40	13708.40	CD
cord-001835-0s7ok4uw	2676	2	g	g	NN
cord-001835-0s7ok4uw	2676	3	/	/	SYM
cord-001835-0s7ok4uw	2676	4	mol	mol	NN
cord-001835-0s7ok4uw	2676	5	,	,	,
cord-001835-0s7ok4uw	2676	6	0.2	0.2	CD
cord-001835-0s7ok4uw	2676	7	M	m	NN
cord-001835-0s7ok4uw	2676	8	sodium	sodium	NN
cord-001835-0s7ok4uw	2676	9	acetate	acetate	NN
cord-001835-0s7ok4uw	2676	10	3	3	CD
cord-001835-0s7ok4uw	2676	11	-4	-4	NNP
cord-001835-0s7ok4uw	2676	12	w	w	NN
cord-001835-0s7ok4uw	2676	13	/	/	SYM
cord-001835-0s7ok4uw	2676	14	v	v	NN
cord-001835-0s7ok4uw	2676	15	NaCl	NaCl	NNP
cord-001835-0s7ok4uw	2676	16	,	,	,
cord-001835-0s7ok4uw	2676	17	pH	ph	NN
cord-001835-0s7ok4uw	2676	18	4.7	4.7	CD
cord-001835-0s7ok4uw	2676	19	buffer	buffer	NN
cord-001835-0s7ok4uw	2676	20	)	)	-RRB-
cord-001835-0s7ok4uw	2676	21	.	.	.
cord-001835-0s7ok4uw	2677	1	The	the	DT
cord-001835-0s7ok4uw	2677	2	experiment	experiment	NN
cord-001835-0s7ok4uw	2677	3	was	be	VBD
cord-001835-0s7ok4uw	2677	4	carried	carry	VBN
cord-001835-0s7ok4uw	2677	5	out	out	RP
cord-001835-0s7ok4uw	2677	6	at	at	IN
cord-001835-0s7ok4uw	2677	7	SPring-8	SPring-8	NNP
cord-001835-0s7ok4uw	2677	8	BL40XU	BL40XU	NNP
cord-001835-0s7ok4uw	2677	9	.	.	.
cord-001835-0s7ok4uw	2678	1	From	from	IN
cord-001835-0s7ok4uw	2678	2	DXT	DXT	NNP
cord-001835-0s7ok4uw	2678	3	analysis	analysis	NN
cord-001835-0s7ok4uw	2678	4	,	,	,
cord-001835-0s7ok4uw	2678	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2678	6	obtained	obtain	VBD
cord-001835-0s7ok4uw	2678	7	logarithmic	logarithmic	JJ
cord-001835-0s7ok4uw	2678	8	rotational	rotational	JJ
cord-001835-0s7ok4uw	2678	9	velocity	velocity	NN
cord-001835-0s7ok4uw	2678	10	distribution	distribution	NN
cord-001835-0s7ok4uw	2678	11	of	of	IN
cord-001835-0s7ok4uw	2678	12	20	20	CD
cord-001835-0s7ok4uw	2678	13	mg	mg	NNP
cord-001835-0s7ok4uw	2678	14	/	/	SYM
cord-001835-0s7ok4uw	2678	15	ml	ml	NNP
cord-001835-0s7ok4uw	2678	16	,	,	,
cord-001835-0s7ok4uw	2678	17	10	10	CD
cord-001835-0s7ok4uw	2678	18	mg	mg	NNP
cord-001835-0s7ok4uw	2678	19	/	/	SYM
cord-001835-0s7ok4uw	2678	20	ml	ml	IN
cord-001835-0s7ok4uw	2678	21	lysozyme	lysozyme	NN
cord-001835-0s7ok4uw	2678	22	solution	solution	NN
cord-001835-0s7ok4uw	2678	23	and	and	CC
cord-001835-0s7ok4uw	2678	24	20	20	CD
cord-001835-0s7ok4uw	2678	25	mg	mg	NNP
cord-001835-0s7ok4uw	2678	26	/	/	SYM
cord-001835-0s7ok4uw	2678	27	ml	ml	NNP
cord-001835-0s7ok4uw	2678	28	,	,	,
cord-001835-0s7ok4uw	2678	29	10	10	CD
cord-001835-0s7ok4uw	2678	30	mg	mg	NNP
cord-001835-0s7ok4uw	2678	31	/	/	SYM
cord-001835-0s7ok4uw	2678	32	ml	ml	NNS
cord-001835-0s7ok4uw	2678	33	of	of	IN
cord-001835-0s7ok4uw	2678	34	Ribonuclease	Ribonuclease	NNP
cord-001835-0s7ok4uw	2678	35	A	a	DT
cord-001835-0s7ok4uw	2678	36	solution	solution	NN
cord-001835-0s7ok4uw	2678	37	during	during	IN
cord-001835-0s7ok4uw	2678	38	1000	1000	CD
cord-001835-0s7ok4uw	2678	39	ms	ms	NNP
cord-001835-0s7ok4uw	2679	1	and	and	CC
cord-001835-0s7ok4uw	2679	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2679	3	processed	process	VBD
cord-001835-0s7ok4uw	2679	4	regression	regression	NN
cord-001835-0s7ok4uw	2679	5	analysis	analysis	NN
cord-001835-0s7ok4uw	2679	6	of	of	IN
cord-001835-0s7ok4uw	2679	7	Gaussian	gaussian	JJ
cord-001835-0s7ok4uw	2679	8	fitting	fitting	NN
cord-001835-0s7ok4uw	2679	9	in	in	IN
cord-001835-0s7ok4uw	2679	10	each	each	DT
cord-001835-0s7ok4uw	2679	11	distribution	distribution	NN
cord-001835-0s7ok4uw	2679	12	.	.	.
cord-001835-0s7ok4uw	2680	1	From	from	IN
cord-001835-0s7ok4uw	2680	2	this	this	DT
cord-001835-0s7ok4uw	2680	3	result	result	NN
cord-001835-0s7ok4uw	2680	4	,	,	,
cord-001835-0s7ok4uw	2680	5	10	10	CD
cord-001835-0s7ok4uw	2680	6	mg	mg	NNP
cord-001835-0s7ok4uw	2680	7	/	/	SYM
cord-001835-0s7ok4uw	2680	8	ml	ml	NN
cord-001835-0s7ok4uw	2680	9	of	of	IN
cord-001835-0s7ok4uw	2680	10	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	2680	11	solution	solution	NN
cord-001835-0s7ok4uw	2680	12	(	(	-LRB-
cord-001835-0s7ok4uw	2680	13	stable	stable	JJ
cord-001835-0s7ok4uw	2680	14	)	)	-RRB-
cord-001835-0s7ok4uw	2680	15	and	and	CC
cord-001835-0s7ok4uw	2680	16	20	20	CD
cord-001835-0s7ok4uw	2680	17	mg	mg	NNP
cord-001835-0s7ok4uw	2680	18	/	/	SYM
cord-001835-0s7ok4uw	2680	19	ml	ml	NNP
cord-001835-0s7ok4uw	2680	20	,	,	,
cord-001835-0s7ok4uw	2680	21	10	10	CD
cord-001835-0s7ok4uw	2680	22	mg	mg	NNP
cord-001835-0s7ok4uw	2680	23	/	/	SYM
cord-001835-0s7ok4uw	2680	24	ml	ml	NN
cord-001835-0s7ok4uw	2680	25	(	(	-LRB-
cord-001835-0s7ok4uw	2680	26	reference	reference	NN
cord-001835-0s7ok4uw	2680	27	)	)	-RRB-
cord-001835-0s7ok4uw	2680	28	have	have	VBP
cord-001835-0s7ok4uw	2680	29	definitely	definitely	RB
cord-001835-0s7ok4uw	2680	30	regressed	regress	VBN
cord-001835-0s7ok4uw	2680	31	by	by	IN
cord-001835-0s7ok4uw	2680	32	single	single	JJ
cord-001835-0s7ok4uw	2680	33	peak	peak	NN
cord-001835-0s7ok4uw	2680	34	normal	normal	JJ
cord-001835-0s7ok4uw	2680	35	Gaussian	gaussian	JJ
cord-001835-0s7ok4uw	2680	36	distribution	distribution	NN
cord-001835-0s7ok4uw	2680	37	that	that	WDT
cord-001835-0s7ok4uw	2680	38	are	be	VBP
cord-001835-0s7ok4uw	2680	39	positional	positional	JJ
cord-001835-0s7ok4uw	2680	40	peaks	peak	NNS
cord-001835-0s7ok4uw	2680	41	at	at	IN
cord-001835-0s7ok4uw	2680	42	3.66	3.66	CD
cord-001835-0s7ok4uw	2680	43	mrad	mrad	NN
cord-001835-0s7ok4uw	2680	44	and	and	CC
cord-001835-0s7ok4uw	2680	45	1.4	1.4	CD
cord-001835-0s7ok4uw	2680	46	mrad	mrad	NNS
cord-001835-0s7ok4uw	2680	47	and	and	CC
cord-001835-0s7ok4uw	2680	48	1.2	1.2	CD
cord-001835-0s7ok4uw	2680	49	mrad	mrad	NN
cord-001835-0s7ok4uw	2680	50	,	,	,
cord-001835-0s7ok4uw	2680	51	respectively	respectively	RB
cord-001835-0s7ok4uw	2680	52	.	.	.
cord-001835-0s7ok4uw	2681	1	In	in	IN
cord-001835-0s7ok4uw	2681	2	contrast	contrast	NN
cord-001835-0s7ok4uw	2681	3	,	,	,
cord-001835-0s7ok4uw	2681	4	20	20	CD
cord-001835-0s7ok4uw	2681	5	mg	mg	NNP
cord-001835-0s7ok4uw	2681	6	/	/	SYM
cord-001835-0s7ok4uw	2681	7	ml	ml	NN
cord-001835-0s7ok4uw	2681	8	of	of	IN
cord-001835-0s7ok4uw	2681	9	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	2681	10	solution	solution	NN
cord-001835-0s7ok4uw	2681	11	consisted	consist	VBN
cord-001835-0s7ok4uw	2681	12	of	of	IN
cord-001835-0s7ok4uw	2681	13	double	double	JJ
cord-001835-0s7ok4uw	2681	14	peak	peak	JJ
cord-001835-0s7ok4uw	2681	15	logarithmic	logarithmic	JJ
cord-001835-0s7ok4uw	2681	16	distribution	distribution	NN
cord-001835-0s7ok4uw	2681	17	at	at	IN
cord-001835-0s7ok4uw	2681	18	3.42	3.42	CD
cord-001835-0s7ok4uw	2681	19	and	and	CC
cord-001835-0s7ok4uw	2681	20	9.54	9.54	CD
cord-001835-0s7ok4uw	2681	21	mrad	mrad	NN
cord-001835-0s7ok4uw	2681	22	.	.	.
cord-001835-0s7ok4uw	2682	1	This	this	DT
cord-001835-0s7ok4uw	2682	2	peak	peak	NN
cord-001835-0s7ok4uw	2682	3	separation	separation	NN
cord-001835-0s7ok4uw	2682	4	tendency	tendency	NN
cord-001835-0s7ok4uw	2682	5	from	from	IN
cord-001835-0s7ok4uw	2682	6	DXT	DXT	NNP
cord-001835-0s7ok4uw	2682	7	are	be	VBP
cord-001835-0s7ok4uw	2682	8	typically	typically	RB
cord-001835-0s7ok4uw	2682	9	observed	observe	VBN
cord-001835-0s7ok4uw	2682	10	in	in	IN
cord-001835-0s7ok4uw	2682	11	a	a	DT
cord-001835-0s7ok4uw	2682	12	supersaturated	supersaturated	JJ
cord-001835-0s7ok4uw	2682	13	condition	condition	NN
cord-001835-0s7ok4uw	2682	14	of	of	IN
cord-001835-0s7ok4uw	2682	15	the	the	DT
cord-001835-0s7ok4uw	2682	16	sodium	sodium	NN
cord-001835-0s7ok4uw	2682	17	acetate	acetate	NN
cord-001835-0s7ok4uw	2682	18	solution	solution	NN
cord-001835-0s7ok4uw	2682	19	which	which	WDT
cord-001835-0s7ok4uw	2682	20	coexisting	coexist	VBG
cord-001835-0s7ok4uw	2682	21	nano	nano	NN
cord-001835-0s7ok4uw	2682	22	-	-	HYPH
cord-001835-0s7ok4uw	2682	23	scale	scale	NN
cord-001835-0s7ok4uw	2682	24	solute	solute	NN
cord-001835-0s7ok4uw	2682	25	networks	network	NNS
cord-001835-0s7ok4uw	2682	26	(	(	-LRB-
cord-001835-0s7ok4uw	2682	27	DXT	DXT	NNP
cord-001835-0s7ok4uw	2682	28	and	and	CC
cord-001835-0s7ok4uw	2682	29	Small	Small	NNP
cord-001835-0s7ok4uw	2682	30	Angle	Angle	NNP
cord-001835-0s7ok4uw	2682	31	X	x	NN
cord-001835-0s7ok4uw	2682	32	-	-	NN
cord-001835-0s7ok4uw	2682	33	ray	ray	NN
cord-001835-0s7ok4uw	2682	34	Scattering	scattering	NN
cord-001835-0s7ok4uw	2682	35	(	(	-LRB-
cord-001835-0s7ok4uw	2682	36	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	2682	37	)	)	-RRB-
cord-001835-0s7ok4uw	2682	38	experiment	experiment	NN
cord-001835-0s7ok4uw	2682	39	)	)	-RRB-
cord-001835-0s7ok4uw	2682	40	.	.	.
cord-001835-0s7ok4uw	2683	1	From	from	IN
cord-001835-0s7ok4uw	2683	2	this	this	DT
cord-001835-0s7ok4uw	2683	3	study	study	NN
cord-001835-0s7ok4uw	2683	4	,	,	,
cord-001835-0s7ok4uw	2683	5	DXT	DXT	NNP
cord-001835-0s7ok4uw	2683	6	measurement	measurement	NN
cord-001835-0s7ok4uw	2683	7	results	result	NNS
cord-001835-0s7ok4uw	2683	8	and	and	CC
cord-001835-0s7ok4uw	2683	9	detailed	detailed	JJ
cord-001835-0s7ok4uw	2683	10	analysis	analysis	NN
cord-001835-0s7ok4uw	2683	11	process	process	NN
cord-001835-0s7ok4uw	2683	12	for	for	IN
cord-001835-0s7ok4uw	2683	13	a	a	DT
cord-001835-0s7ok4uw	2683	14	protein	protein	NN
cord-001835-0s7ok4uw	2683	15	solution	solution	NN
cord-001835-0s7ok4uw	2683	16	such	such	JJ
cord-001835-0s7ok4uw	2683	17	as	as	IN
cord-001835-0s7ok4uw	2683	18	crystal	crystal	NN
cord-001835-0s7ok4uw	2683	19	precursor	precursor	NN
cord-001835-0s7ok4uw	2683	20	metastable	metastable	JJ
cord-001835-0s7ok4uw	2683	21	state	state	NN
cord-001835-0s7ok4uw	2683	22	of	of	IN
cord-001835-0s7ok4uw	2683	23	lysozyme	lysozyme	NNS
cord-001835-0s7ok4uw	2683	24	solution	solution	NN
cord-001835-0s7ok4uw	2683	25	are	be	VBP
cord-001835-0s7ok4uw	2683	26	concerned	concerned	JJ
cord-001835-0s7ok4uw	2683	27	that	that	IN
cord-001835-0s7ok4uw	2683	28	this	this	DT
cord-001835-0s7ok4uw	2683	29	technique	technique	NN
cord-001835-0s7ok4uw	2683	30	is	be	VBZ
cord-001835-0s7ok4uw	2683	31	a	a	DT
cord-001835-0s7ok4uw	2683	32	powerful	powerful	JJ
cord-001835-0s7ok4uw	2683	33	tool	tool	NN
cord-001835-0s7ok4uw	2683	34	for	for	IN
cord-001835-0s7ok4uw	2683	35	observing	observe	VBG
cord-001835-0s7ok4uw	2683	36	nano	nano	NN
cord-001835-0s7ok4uw	2683	37	-	-	HYPH
cord-001835-0s7ok4uw	2683	38	scale	scale	NN
cord-001835-0s7ok4uw	2683	39	protein	protein	NN
cord-001835-0s7ok4uw	2683	40	network	network	NN
cord-001835-0s7ok4uw	2683	41	's	's	POS
cord-001835-0s7ok4uw	2683	42	existence	existence	NN
cord-001835-0s7ok4uw	2683	43	and	and	CC
cord-001835-0s7ok4uw	2683	44	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2683	45	local	local	JJ
cord-001835-0s7ok4uw	2683	46	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2683	47	in	in	IN
cord-001835-0s7ok4uw	2683	48	bulk	bulk	JJ
cord-001835-0s7ok4uw	2683	49	solution	solution	NN
cord-001835-0s7ok4uw	2683	50	.	.	.
cord-001835-0s7ok4uw	2684	1	At	at	IN
cord-001835-0s7ok4uw	2684	2	the	the	DT
cord-001835-0s7ok4uw	2684	3	present	present	JJ
cord-001835-0s7ok4uw	2684	4	time	time	NN
cord-001835-0s7ok4uw	2684	5	,	,	,
cord-001835-0s7ok4uw	2684	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	2684	7	will	will	MD
cord-001835-0s7ok4uw	2684	8	demonstrate	demonstrate	VB
cord-001835-0s7ok4uw	2684	9	the	the	DT
cord-001835-0s7ok4uw	2684	10	detailed	detailed	JJ
cord-001835-0s7ok4uw	2684	11	analysis	analysis	NN
cord-001835-0s7ok4uw	2684	12	and	and	CC
cord-001835-0s7ok4uw	2684	13	processing	processing	NN
cord-001835-0s7ok4uw	2684	14	from	from	IN
cord-001835-0s7ok4uw	2684	15	DXT	DXT	NNP
cord-001835-0s7ok4uw	2684	16	raw	raw	JJ
cord-001835-0s7ok4uw	2684	17	data	datum	NNS
cord-001835-0s7ok4uw	2684	18	and	and	CC
cord-001835-0s7ok4uw	2684	19	the	the	DT
cord-001835-0s7ok4uw	2684	20	conformity	conformity	NN
cord-001835-0s7ok4uw	2684	21	of	of	IN
cord-001835-0s7ok4uw	2684	22	the	the	DT
cord-001835-0s7ok4uw	2684	23	results	result	NNS
cord-001835-0s7ok4uw	2684	24	from	from	IN
cord-001835-0s7ok4uw	2684	25	another	another	DT
cord-001835-0s7ok4uw	2684	26	experiment	experiment	NN
cord-001835-0s7ok4uw	2684	27	confirmation	confirmation	NN
cord-001835-0s7ok4uw	2684	28	such	such	JJ
cord-001835-0s7ok4uw	2684	29	as	as	IN
cord-001835-0s7ok4uw	2684	30	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	2684	31	and	and	CC
cord-001835-0s7ok4uw	2684	32	Darkfield	Darkfield	NNP
cord-001835-0s7ok4uw	2684	33	microscopy	microscopy	NNS
cord-001835-0s7ok4uw	2684	34	.	.	.
cord-001835-0s7ok4uw	2685	1	Finally	finally	RB
cord-001835-0s7ok4uw	2685	2	,	,	,
cord-001835-0s7ok4uw	2685	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2685	4	present	present	VBP
cord-001835-0s7ok4uw	2685	5	a	a	DT
cord-001835-0s7ok4uw	2685	6	detailed	detailed	JJ
cord-001835-0s7ok4uw	2685	7	protein	protein	NN
cord-001835-0s7ok4uw	2685	8	network	network	NN
cord-001835-0s7ok4uw	2685	9	model	model	NN
cord-001835-0s7ok4uw	2685	10	of	of	IN
cord-001835-0s7ok4uw	2685	11	lysozyme	lysozyme	NN
cord-001835-0s7ok4uw	2685	12	metastable	metastable	JJ
cord-001835-0s7ok4uw	2685	13	solution	solution	NN
cord-001835-0s7ok4uw	2685	14	from	from	IN
cord-001835-0s7ok4uw	2685	15	DXT	DXT	NNP
cord-001835-0s7ok4uw	2685	16	result	result	NN
cord-001835-0s7ok4uw	2685	17	.	.	.
cord-001835-0s7ok4uw	2686	1	Increasing	increase	VBG
cord-001835-0s7ok4uw	2686	2	evidence	evidence	NN
cord-001835-0s7ok4uw	2686	3	suggests	suggest	VBZ
cord-001835-0s7ok4uw	2686	4	that	that	IN
cord-001835-0s7ok4uw	2686	5	conformational	conformational	JJ
cord-001835-0s7ok4uw	2686	6	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	2686	7	experienced	experience	VBN
cord-001835-0s7ok4uw	2686	8	by	by	IN
cord-001835-0s7ok4uw	2686	9	proteins	protein	NNS
cord-001835-0s7ok4uw	2686	10	play	play	VBP
cord-001835-0s7ok4uw	2686	11	a	a	DT
cord-001835-0s7ok4uw	2686	12	key	key	JJ
cord-001835-0s7ok4uw	2686	13	role	role	NN
cord-001835-0s7ok4uw	2686	14	in	in	IN
cord-001835-0s7ok4uw	2686	15	promoting	promote	VBG
cord-001835-0s7ok4uw	2686	16	function	function	NN
cord-001835-0s7ok4uw	2686	17	.	.	.
cord-001835-0s7ok4uw	2687	1	However	however	RB
cord-001835-0s7ok4uw	2687	2	,	,	,
cord-001835-0s7ok4uw	2687	3	the	the	DT
cord-001835-0s7ok4uw	2687	4	experimentally	experimentally	RB
cord-001835-0s7ok4uw	2687	5	derived	derive	VBN
cord-001835-0s7ok4uw	2687	6	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2687	7	behavior	behavior	NN
cord-001835-0s7ok4uw	2687	8	of	of	IN
cord-001835-0s7ok4uw	2687	9	discrete	discrete	JJ
cord-001835-0s7ok4uw	2687	10	protein	protein	NN
cord-001835-0s7ok4uw	2687	11	systems	system	NNS
cord-001835-0s7ok4uw	2687	12	has	have	VBZ
cord-001835-0s7ok4uw	2687	13	yet	yet	RB
cord-001835-0s7ok4uw	2687	14	to	to	TO
cord-001835-0s7ok4uw	2687	15	provide	provide	VB
cord-001835-0s7ok4uw	2687	16	clear	clear	JJ
cord-001835-0s7ok4uw	2687	17	evidence	evidence	NN
cord-001835-0s7ok4uw	2687	18	on	on	IN
cord-001835-0s7ok4uw	2687	19	the	the	DT
cord-001835-0s7ok4uw	2687	20	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	2687	21	conservation	conservation	NN
cord-001835-0s7ok4uw	2687	22	of	of	IN
cord-001835-0s7ok4uw	2687	23	motional	motional	JJ
cord-001835-0s7ok4uw	2687	24	events	event	NNS
cord-001835-0s7ok4uw	2687	25	between	between	IN
cord-001835-0s7ok4uw	2687	26	structural	structural	JJ
cord-001835-0s7ok4uw	2687	27	and	and	CC
cord-001835-0s7ok4uw	2687	28	functional	functional	JJ
cord-001835-0s7ok4uw	2687	29	protein	protein	NN
cord-001835-0s7ok4uw	2687	30	homologues	homologue	NNS
cord-001835-0s7ok4uw	2687	31	.	.	.
cord-001835-0s7ok4uw	2688	1	In	in	IN
cord-001835-0s7ok4uw	2688	2	this	this	DT
cord-001835-0s7ok4uw	2688	3	work	work	NN
cord-001835-0s7ok4uw	2688	4	,	,	,
cord-001835-0s7ok4uw	2688	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2688	6	used	use	VBD
cord-001835-0s7ok4uw	2688	7	a	a	DT
cord-001835-0s7ok4uw	2688	8	statistical	statistical	JJ
cord-001835-0s7ok4uw	2688	9	coupling	coupling	NN
cord-001835-0s7ok4uw	2688	10	analysis	analysis	NN
cord-001835-0s7ok4uw	2688	11	(	(	-LRB-
cord-001835-0s7ok4uw	2688	12	SCA	SCA	NNP
cord-001835-0s7ok4uw	2688	13	)	)	-RRB-
cord-001835-0s7ok4uw	2688	14	approach	approach	NN
cord-001835-0s7ok4uw	2688	15	to	to	TO
cord-001835-0s7ok4uw	2688	16	analyze	analyze	VB
cord-001835-0s7ok4uw	2688	17	the	the	DT
cord-001835-0s7ok4uw	2688	18	role	role	NN
cord-001835-0s7ok4uw	2688	19	of	of	IN
cord-001835-0s7ok4uw	2688	20	co	co	JJ
cord-001835-0s7ok4uw	2688	21	-	-	JJ
cord-001835-0s7ok4uw	2688	22	evolving	evolve	VBG
cord-001835-0s7ok4uw	2688	23	amino	amino	NN
cord-001835-0s7ok4uw	2688	24	acids	acid	NNS
cord-001835-0s7ok4uw	2688	25	in	in	IN
cord-001835-0s7ok4uw	2688	26	protein	protein	NN
cord-001835-0s7ok4uw	2688	27	function	function	NN
cord-001835-0s7ok4uw	2688	28	and	and	CC
cord-001835-0s7ok4uw	2688	29	flexibility	flexibility	NN
cord-001835-0s7ok4uw	2688	30	.	.	.
cord-001835-0s7ok4uw	2689	1	SCA	SCA	NNP
cord-001835-0s7ok4uw	2689	2	facilitates	facilitate	VBZ
cord-001835-0s7ok4uw	2689	3	the	the	DT
cord-001835-0s7ok4uw	2689	4	identification	identification	NN
cord-001835-0s7ok4uw	2689	5	of	of	IN
cord-001835-0s7ok4uw	2689	6	distinct	distinct	JJ
cord-001835-0s7ok4uw	2689	7	residue	residue	NN
cord-001835-0s7ok4uw	2689	8	sectors	sector	NNS
cord-001835-0s7ok4uw	2689	9	and	and	CC
cord-001835-0s7ok4uw	2689	10	provides	provide	VBZ
cord-001835-0s7ok4uw	2689	11	an	an	DT
cord-001835-0s7ok4uw	2689	12	understanding	understanding	NN
cord-001835-0s7ok4uw	2689	13	of	of	IN
cord-001835-0s7ok4uw	2689	14	the	the	DT
cord-001835-0s7ok4uw	2689	15	correlation	correlation	NN
cord-001835-0s7ok4uw	2689	16	between	between	IN
cord-001835-0s7ok4uw	2689	17	amino	amino	NN
cord-001835-0s7ok4uw	2689	18	acid	acid	NN
cord-001835-0s7ok4uw	2689	19	co	co	NN
cord-001835-0s7ok4uw	2689	20	-	-	NN
cord-001835-0s7ok4uw	2689	21	evolution	evolution	JJ
cord-001835-0s7ok4uw	2689	22	and	and	CC
cord-001835-0s7ok4uw	2689	23	biological	biological	JJ
cord-001835-0s7ok4uw	2689	24	function	function	NN
cord-001835-0s7ok4uw	2689	25	.	.	.
cord-001835-0s7ok4uw	2690	1	As	as	IN
cord-001835-0s7ok4uw	2690	2	a	a	DT
cord-001835-0s7ok4uw	2690	3	model	model	NN
cord-001835-0s7ok4uw	2690	4	system	system	NN
cord-001835-0s7ok4uw	2690	5	,	,	,
cord-001835-0s7ok4uw	2690	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	2690	7	used	use	VBD
cord-001835-0s7ok4uw	2690	8	the	the	DT
cord-001835-0s7ok4uw	2690	9	Ribonuclease	Ribonuclease	NNP
cord-001835-0s7ok4uw	2690	10	A	A	NNP
cord-001835-0s7ok4uw	2690	11	(	(	-LRB-
cord-001835-0s7ok4uw	2690	12	RNase	RNase	NNP
cord-001835-0s7ok4uw	2690	13	A	A	NNP
cord-001835-0s7ok4uw	2690	14	)	)	-RRB-
cord-001835-0s7ok4uw	2690	15	family	family	NN
cord-001835-0s7ok4uw	2690	16	,	,	,
cord-001835-0s7ok4uw	2690	17	which	which	WDT
cord-001835-0s7ok4uw	2690	18	includes	include	VBZ
cord-001835-0s7ok4uw	2690	19	canonical	canonical	JJ
cord-001835-0s7ok4uw	2690	20	members	member	NNS
cord-001835-0s7ok4uw	2690	21	that	that	WDT
cord-001835-0s7ok4uw	2690	22	are	be	VBP
cord-001835-0s7ok4uw	2690	23	structurally	structurally	RB
cord-001835-0s7ok4uw	2690	24	similar	similar	JJ
cord-001835-0s7ok4uw	2690	25	,	,	,
cord-001835-0s7ok4uw	2690	26	but	but	CC
cord-001835-0s7ok4uw	2690	27	perform	perform	VB
cord-001835-0s7ok4uw	2690	28	diverse	diverse	JJ
cord-001835-0s7ok4uw	2690	29	activities	activity	NNS
cord-001835-0s7ok4uw	2690	30	such	such	JJ
cord-001835-0s7ok4uw	2690	31	as	as	IN
cord-001835-0s7ok4uw	2690	32	angiogenesis	angiogenesis	NN
cord-001835-0s7ok4uw	2690	33	,	,	,
cord-001835-0s7ok4uw	2690	34	anti	anti	JJ
cord-001835-0s7ok4uw	2690	35	-	-	NN
cord-001835-0s7ok4uw	2690	36	pathogenicity	pathogenicity	NN
cord-001835-0s7ok4uw	2690	37	and	and	CC
cord-001835-0s7ok4uw	2690	38	neurotoxicity	neurotoxicity	NN
cord-001835-0s7ok4uw	2690	39	,	,	,
cord-001835-0s7ok4uw	2690	40	while	while	IN
cord-001835-0s7ok4uw	2690	41	preserving	preserve	VBG
cord-001835-0s7ok4uw	2690	42	the	the	DT
cord-001835-0s7ok4uw	2690	43	common	common	JJ
cord-001835-0s7ok4uw	2690	44	ribonucleolytic	ribonucleolytic	JJ
cord-001835-0s7ok4uw	2690	45	function	function	NN
cord-001835-0s7ok4uw	2690	46	.	.	.
cord-001835-0s7ok4uw	2691	1	Analysis	analysis	NN
cord-001835-0s7ok4uw	2691	2	of	of	IN
cord-001835-0s7ok4uw	2691	3	1922	1922	CD
cord-001835-0s7ok4uw	2691	4	sequences	sequence	NNS
cord-001835-0s7ok4uw	2691	5	with	with	IN
cord-001835-0s7ok4uw	2691	6	SCA	SCA	NNP
cord-001835-0s7ok4uw	2691	7	6.0	6.0	NNP
cord-001835-0s7ok4uw	2691	8	allowed	allow	VBD
cord-001835-0s7ok4uw	2691	9	the	the	DT
cord-001835-0s7ok4uw	2691	10	determination	determination	NN
cord-001835-0s7ok4uw	2691	11	of	of	IN
cord-001835-0s7ok4uw	2691	12	five	five	CD
cord-001835-0s7ok4uw	2691	13	independent	independent	JJ
cord-001835-0s7ok4uw	2691	14	components	component	NNS
cord-001835-0s7ok4uw	2691	15	(	(	-LRB-
cord-001835-0s7ok4uw	2691	16	ICs	ICs	NNP
cord-001835-0s7ok4uw	2691	17	)	)	-RRB-
cord-001835-0s7ok4uw	2691	18	corresponding	correspond	VBG
cord-001835-0s7ok4uw	2691	19	to	to	IN
cord-001835-0s7ok4uw	2691	20	amino	amino	NN
cord-001835-0s7ok4uw	2691	21	-	-	HYPH
cord-001835-0s7ok4uw	2691	22	acid	acid	NN
cord-001835-0s7ok4uw	2691	23	sectors	sector	NNS
cord-001835-0s7ok4uw	2691	24	with	with	IN
cord-001835-0s7ok4uw	2691	25	distinct	distinct	JJ
cord-001835-0s7ok4uw	2691	26	functional	functional	JJ
cord-001835-0s7ok4uw	2691	27	,	,	,
cord-001835-0s7ok4uw	2691	28	structural	structural	JJ
cord-001835-0s7ok4uw	2691	29	and/	and/	CD
cord-001835-0s7ok4uw	2691	30	or	or	CC
cord-001835-0s7ok4uw	2691	31	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	2691	32	roles	role	NNS
cord-001835-0s7ok4uw	2691	33	within	within	IN
cord-001835-0s7ok4uw	2691	34	the	the	DT
cord-001835-0s7ok4uw	2691	35	family	family	NN
cord-001835-0s7ok4uw	2691	36	.	.	.
cord-001835-0s7ok4uw	2692	1	While	while	IN
cord-001835-0s7ok4uw	2692	2	most	most	JJS
cord-001835-0s7ok4uw	2692	3	ICs	ic	NNS
cord-001835-0s7ok4uw	2692	4	correspond	correspond	VBP
cord-001835-0s7ok4uw	2692	5	to	to	IN
cord-001835-0s7ok4uw	2692	6	residues	residue	NNS
cord-001835-0s7ok4uw	2692	7	critical	critical	JJ
cord-001835-0s7ok4uw	2692	8	for	for	IN
cord-001835-0s7ok4uw	2692	9	protein	protein	NN
cord-001835-0s7ok4uw	2692	10	stability	stability	NN
cord-001835-0s7ok4uw	2692	11	and	and	CC
cord-001835-0s7ok4uw	2692	12	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2692	13	function	function	NN
cord-001835-0s7ok4uw	2692	14	,	,	,
cord-001835-0s7ok4uw	2692	15	IC4	ic4	NN
cord-001835-0s7ok4uw	2692	16	correlates	correlate	VBZ
cord-001835-0s7ok4uw	2692	17	with	with	IN
cord-001835-0s7ok4uw	2692	18	residues	residue	NNS
cord-001835-0s7ok4uw	2692	19	experimentally	experimentally	RB
cord-001835-0s7ok4uw	2692	20	determined	determine	VBD
cord-001835-0s7ok4uw	2692	21	to	to	TO
cord-001835-0s7ok4uw	2692	22	be	be	VB
cord-001835-0s7ok4uw	2692	23	highly	highly	RB
cord-001835-0s7ok4uw	2692	24	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2692	25	on	on	IN
cord-001835-0s7ok4uw	2692	26	the	the	DT
cord-001835-0s7ok4uw	2692	27	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2692	28	timescale	timescale	NN
cord-001835-0s7ok4uw	2692	29	in	in	IN
cord-001835-0s7ok4uw	2692	30	several	several	JJ
cord-001835-0s7ok4uw	2692	31	RNase	rnase	NN
cord-001835-0s7ok4uw	2692	32	A	a	DT
cord-001835-0s7ok4uw	2692	33	homologues	homologue	NNS
cord-001835-0s7ok4uw	2692	34	,	,	,
cord-001835-0s7ok4uw	2692	35	as	as	IN
cord-001835-0s7ok4uw	2692	36	we	-PRON-	PRP
cord-001835-0s7ok4uw	2692	37	confirmed	confirm	VBD
cord-001835-0s7ok4uw	2692	38	by	by	IN
cord-001835-0s7ok4uw	2692	39	NMR	NMR	NNP
cord-001835-0s7ok4uw	2692	40	15N	15N	NNP
cord-001835-0s7ok4uw	2692	41	-	-	HYPH
cord-001835-0s7ok4uw	2692	42	CPMG	CPMG	NNP
cord-001835-0s7ok4uw	2692	43	experiments	experiment	NNS
cord-001835-0s7ok4uw	2692	44	.	.	.
cord-001835-0s7ok4uw	2693	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	2693	2	,	,	,
cord-001835-0s7ok4uw	2693	3	IC5	ic5	JJ
cord-001835-0s7ok4uw	2693	4	residues	residue	NNS
cord-001835-0s7ok4uw	2693	5	form	form	VBP
cord-001835-0s7ok4uw	2693	6	a	a	DT
cord-001835-0s7ok4uw	2693	7	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2693	8	-	-	HYPH
cord-001835-0s7ok4uw	2693	9	bonding	bonding	NN
cord-001835-0s7ok4uw	2693	10	network	network	NN
cord-001835-0s7ok4uw	2693	11	shown	show	VBN
cord-001835-0s7ok4uw	2693	12	to	to	TO
cord-001835-0s7ok4uw	2693	13	allosterically	allosterically	RB
cord-001835-0s7ok4uw	2693	14	modulate	modulate	VB
cord-001835-0s7ok4uw	2693	15	and	and	CC
cord-001835-0s7ok4uw	2693	16	coordinate	coordinate	VB
cord-001835-0s7ok4uw	2693	17	catalytically	catalytically	RB
cord-001835-0s7ok4uw	2693	18	productive	productive	JJ
cord-001835-0s7ok4uw	2693	19	motions	motion	NNS
cord-001835-0s7ok4uw	2693	20	.	.	.
cord-001835-0s7ok4uw	2694	1	These	these	DT
cord-001835-0s7ok4uw	2694	2	results	result	NNS
cord-001835-0s7ok4uw	2694	3	provide	provide	VBP
cord-001835-0s7ok4uw	2694	4	a	a	DT
cord-001835-0s7ok4uw	2694	5	direct	direct	JJ
cord-001835-0s7ok4uw	2694	6	observation	observation	NN
cord-001835-0s7ok4uw	2694	7	between	between	IN
cord-001835-0s7ok4uw	2694	8	the	the	DT
cord-001835-0s7ok4uw	2694	9	role	role	NN
cord-001835-0s7ok4uw	2694	10	of	of	IN
cord-001835-0s7ok4uw	2694	11	residue	residue	JJ
cord-001835-0s7ok4uw	2694	12	sectors	sector	NNS
cord-001835-0s7ok4uw	2694	13	in	in	IN
cord-001835-0s7ok4uw	2694	14	stability	stability	NN
cord-001835-0s7ok4uw	2694	15	and	and	CC
cord-001835-0s7ok4uw	2694	16	motions	motion	NNS
cord-001835-0s7ok4uw	2694	17	relevant	relevant	JJ
cord-001835-0s7ok4uw	2694	18	to	to	TO
cord-001835-0s7ok4uw	2694	19	function	function	VB
cord-001835-0s7ok4uw	2694	20	in	in	IN
cord-001835-0s7ok4uw	2694	21	the	the	DT
cord-001835-0s7ok4uw	2694	22	RNase	RNase	NNP
cord-001835-0s7ok4uw	2694	23	A	a	DT
cord-001835-0s7ok4uw	2694	24	family	family	NN
cord-001835-0s7ok4uw	2694	25	.	.	.
cord-001835-0s7ok4uw	2695	1	This	this	DT
cord-001835-0s7ok4uw	2695	2	study	study	NN
cord-001835-0s7ok4uw	2695	3	highlights	highlight	VBZ
cord-001835-0s7ok4uw	2695	4	the	the	DT
cord-001835-0s7ok4uw	2695	5	role	role	NN
cord-001835-0s7ok4uw	2695	6	of	of	IN
cord-001835-0s7ok4uw	2695	7	concerted	concerted	JJ
cord-001835-0s7ok4uw	2695	8	action	action	NN
cord-001835-0s7ok4uw	2695	9	of	of	IN
cord-001835-0s7ok4uw	2695	10	multiple	multiple	JJ
cord-001835-0s7ok4uw	2695	11	residues	residue	NNS
cord-001835-0s7ok4uw	2695	12	towards	towards	IN
cord-001835-0s7ok4uw	2695	13	a	a	DT
cord-001835-0s7ok4uw	2695	14	common	common	JJ
cord-001835-0s7ok4uw	2695	15	function	function	NN
cord-001835-0s7ok4uw	2695	16	,	,	,
cord-001835-0s7ok4uw	2695	17	which	which	WDT
cord-001835-0s7ok4uw	2695	18	can	can	MD
cord-001835-0s7ok4uw	2695	19	guide	guide	VB
cord-001835-0s7ok4uw	2695	20	experiments	experiment	NNS
cord-001835-0s7ok4uw	2695	21	for	for	IN
cord-001835-0s7ok4uw	2695	22	engineering	engineering	NN
cord-001835-0s7ok4uw	2695	23	proteins	protein	NNS
cord-001835-0s7ok4uw	2695	24	to	to	TO
cord-001835-0s7ok4uw	2695	25	enhance	enhance	VB
cord-001835-0s7ok4uw	2695	26	function	function	NN
cord-001835-0s7ok4uw	2695	27	such	such	JJ
cord-001835-0s7ok4uw	2695	28	as	as	IN
cord-001835-0s7ok4uw	2695	29	catalysis	catalysis	NN
cord-001835-0s7ok4uw	2695	30	.	.	.
cord-001835-0s7ok4uw	2695	31	 	 	_SP
cord-001835-0s7ok4uw	2696	1	Halophilic	Halophilic	NNP
cord-001835-0s7ok4uw	2696	2	archea	archea	NNP
cord-001835-0s7ok4uw	2696	3	are	be	VBP
cord-001835-0s7ok4uw	2696	4	a	a	DT
cord-001835-0s7ok4uw	2696	5	type	type	NN
cord-001835-0s7ok4uw	2696	6	of	of	IN
cord-001835-0s7ok4uw	2696	7	extremophiles	extremophile	NNS
cord-001835-0s7ok4uw	2696	8	that	that	WDT
cord-001835-0s7ok4uw	2696	9	thrive	thrive	VBP
cord-001835-0s7ok4uw	2696	10	in	in	IN
cord-001835-0s7ok4uw	2696	11	hypersaline	hypersaline	JJ
cord-001835-0s7ok4uw	2696	12	conditions	condition	NNS
cord-001835-0s7ok4uw	2696	13	.	.	.
cord-001835-0s7ok4uw	2697	1	In	in	IN
cord-001835-0s7ok4uw	2697	2	order	order	NN
cord-001835-0s7ok4uw	2697	3	to	to	TO
cord-001835-0s7ok4uw	2697	4	avoid	avoid	VB
cord-001835-0s7ok4uw	2697	5	the	the	DT
cord-001835-0s7ok4uw	2697	6	osmotic	osmotic	JJ
cord-001835-0s7ok4uw	2697	7	shock	shock	NN
cord-001835-0s7ok4uw	2697	8	,	,	,
cord-001835-0s7ok4uw	2697	9	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2697	10	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	2697	11	is	be	VBZ
cord-001835-0s7ok4uw	2697	12	maintained	maintain	VBN
cord-001835-0s7ok4uw	2697	13	with	with	IN
cord-001835-0s7ok4uw	2697	14	higher	high	JJR
cord-001835-0s7ok4uw	2697	15	ionic	ionic	JJ
cord-001835-0s7ok4uw	2697	16	strength	strength	NN
cord-001835-0s7ok4uw	2697	17	up	up	IN
cord-001835-0s7ok4uw	2697	18	to	to	IN
cord-001835-0s7ok4uw	2697	19	4	4	CD
cord-001835-0s7ok4uw	2697	20	-	-	SYM
cord-001835-0s7ok4uw	2697	21	6M.	6m.	CD
cord-001835-0s7ok4uw	2697	22	Such	such	PDT
cord-001835-0s7ok4uw	2697	23	a	a	DT
cord-001835-0s7ok4uw	2697	24	high	high	JJ
cord-001835-0s7ok4uw	2697	25	ionic	ionic	JJ
cord-001835-0s7ok4uw	2697	26	strength	strength	NN
cord-001835-0s7ok4uw	2697	27	of	of	IN
cord-001835-0s7ok4uw	2697	28	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	2697	29	environment	environment	NN
cord-001835-0s7ok4uw	2697	30	protects	protect	VBZ
cord-001835-0s7ok4uw	2697	31	the	the	DT
cord-001835-0s7ok4uw	2697	32	cells	cell	NNS
cord-001835-0s7ok4uw	2697	33	from	from	IN
cord-001835-0s7ok4uw	2697	34	desiccation	desiccation	NN
cord-001835-0s7ok4uw	2697	35	or	or	CC
cord-001835-0s7ok4uw	2697	36	salting	salting	NN
cord-001835-0s7ok4uw	2697	37	out	out	RP
cord-001835-0s7ok4uw	2697	38	.	.	.
cord-001835-0s7ok4uw	2698	1	However	however	RB
cord-001835-0s7ok4uw	2698	2	,	,	,
cord-001835-0s7ok4uw	2698	3	one	one	NN
cord-001835-0s7ok4uw	2698	4	wonders	wonder	VBZ
cord-001835-0s7ok4uw	2698	5	how	how	WRB
cord-001835-0s7ok4uw	2698	6	such	such	JJ
cord-001835-0s7ok4uw	2698	7	high	high	JJ
cord-001835-0s7ok4uw	2698	8	salt	salt	NN
cord-001835-0s7ok4uw	2698	9	concentrations	concentration	NNS
cord-001835-0s7ok4uw	2698	10	keep	keep	VBP
cord-001835-0s7ok4uw	2698	11	the	the	DT
cord-001835-0s7ok4uw	2698	12	cell	cell	NN
cord-001835-0s7ok4uw	2698	13	functional	functional	JJ
cord-001835-0s7ok4uw	2698	14	and	and	CC
cord-001835-0s7ok4uw	2698	15	active	active	JJ
cord-001835-0s7ok4uw	2698	16	throughout	throughout	IN
cord-001835-0s7ok4uw	2698	17	all	all	PDT
cord-001835-0s7ok4uw	2698	18	the	the	DT
cord-001835-0s7ok4uw	2698	19	cellular	cellular	JJ
cord-001835-0s7ok4uw	2698	20	reactions	reaction	NNS
cord-001835-0s7ok4uw	2698	21	(	(	-LRB-
cord-001835-0s7ok4uw	2698	22	i.e.	i.e.	FW
cord-001835-0s7ok4uw	2698	23	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2698	24	catalysis	catalysis	NN
cord-001835-0s7ok4uw	2698	25	)	)	-RRB-
cord-001835-0s7ok4uw	2698	26	.	.	.
cord-001835-0s7ok4uw	2699	1	The	the	DT
cord-001835-0s7ok4uw	2699	2	answer	answer	NN
cord-001835-0s7ok4uw	2699	3	lies	lie	VBZ
cord-001835-0s7ok4uw	2699	4	in	in	IN
cord-001835-0s7ok4uw	2699	5	the	the	DT
cord-001835-0s7ok4uw	2699	6	evolution	evolution	NN
cord-001835-0s7ok4uw	2699	7	of	of	IN
cord-001835-0s7ok4uw	2699	8	the	the	DT
cord-001835-0s7ok4uw	2699	9	halophiles	halophile	NNS
cord-001835-0s7ok4uw	2699	10	that	that	WDT
cord-001835-0s7ok4uw	2699	11	has	have	VBZ
cord-001835-0s7ok4uw	2699	12	left	leave	VBN
cord-001835-0s7ok4uw	2699	13	the	the	DT
cord-001835-0s7ok4uw	2699	14	halophilic	halophilic	NNP
cord-001835-0s7ok4uw	2699	15	proteins	protein	NNS
cord-001835-0s7ok4uw	2699	16	with	with	IN
cord-001835-0s7ok4uw	2699	17	a	a	DT
cord-001835-0s7ok4uw	2699	18	certain	certain	JJ
cord-001835-0s7ok4uw	2699	19	preference	preference	NN
cord-001835-0s7ok4uw	2699	20	for	for	IN
cord-001835-0s7ok4uw	2699	21	amino	amino	JJ
cord-001835-0s7ok4uw	2699	22	acids	acid	NNS
cord-001835-0s7ok4uw	2699	23	composition	composition	NN
cord-001835-0s7ok4uw	2699	24	[	[	-LRB-
cord-001835-0s7ok4uw	2699	25	1	1	CD
cord-001835-0s7ok4uw	2699	26	]	]	-RRB-
cord-001835-0s7ok4uw	2700	1	(	(	-LRB-
cord-001835-0s7ok4uw	2700	2	prefers	prefer	VBZ
cord-001835-0s7ok4uw	2700	3	more	more	RBR
cord-001835-0s7ok4uw	2700	4	acidic	acidic	JJ
cord-001835-0s7ok4uw	2700	5	residues	residue	NNS
cord-001835-0s7ok4uw	2700	6	and	and	CC
cord-001835-0s7ok4uw	2700	7	overall	overall	JJ
cord-001835-0s7ok4uw	2700	8	decrease	decrease	NN
cord-001835-0s7ok4uw	2700	9	in	in	IN
cord-001835-0s7ok4uw	2700	10	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	2700	11	side	side	NN
cord-001835-0s7ok4uw	2700	12	-	-	HYPH
cord-001835-0s7ok4uw	2700	13	chains	chain	NNS
cord-001835-0s7ok4uw	2700	14	)	)	-RRB-
cord-001835-0s7ok4uw	2700	15	.	.	.
cord-001835-0s7ok4uw	2701	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2701	2	's	be	VBZ
cord-001835-0s7ok4uw	2701	3	also	also	RB
cord-001835-0s7ok4uw	2701	4	known	know	VBN
cord-001835-0s7ok4uw	2701	5	that	that	IN
cord-001835-0s7ok4uw	2701	6	the	the	DT
cord-001835-0s7ok4uw	2701	7	salt	salt	NN
cord-001835-0s7ok4uw	2701	8	concentration	concentration	NN
cord-001835-0s7ok4uw	2701	9	can	can	MD
cord-001835-0s7ok4uw	2701	10	affect	affect	VB
cord-001835-0s7ok4uw	2701	11	the	the	DT
cord-001835-0s7ok4uw	2701	12	activity	activity	NN
cord-001835-0s7ok4uw	2701	13	and	and	CC
cord-001835-0s7ok4uw	2701	14	the	the	DT
cord-001835-0s7ok4uw	2701	15	underlying	underlying	JJ
cord-001835-0s7ok4uw	2701	16	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2701	17	[	[	-LRB-
cord-001835-0s7ok4uw	2701	18	2	2	CD
cord-001835-0s7ok4uw	2701	19	]	]	-RRB-
cord-001835-0s7ok4uw	2701	20	of	of	IN
cord-001835-0s7ok4uw	2701	21	the	the	DT
cord-001835-0s7ok4uw	2701	22	halophilic	halophilic	NNP
cord-001835-0s7ok4uw	2701	23	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	2701	24	.	.	.
cord-001835-0s7ok4uw	2702	1	In	in	IN
cord-001835-0s7ok4uw	2702	2	order	order	NN
cord-001835-0s7ok4uw	2702	3	to	to	TO
cord-001835-0s7ok4uw	2702	4	further	further	RB
cord-001835-0s7ok4uw	2702	5	understand	understand	VB
cord-001835-0s7ok4uw	2702	6	the	the	DT
cord-001835-0s7ok4uw	2702	7	haloadaptation	haloadaptation	NN
cord-001835-0s7ok4uw	2702	8	,	,	,
cord-001835-0s7ok4uw	2702	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	2702	10	have	have	VBP
cord-001835-0s7ok4uw	2702	11	chosen	choose	VBN
cord-001835-0s7ok4uw	2702	12	to	to	TO
cord-001835-0s7ok4uw	2702	13	study	study	VB
cord-001835-0s7ok4uw	2702	14	a	a	DT
cord-001835-0s7ok4uw	2702	15	model	model	NN
cord-001835-0s7ok4uw	2702	16	system	system	NN
cord-001835-0s7ok4uw	2702	17	,	,	,
cord-001835-0s7ok4uw	2702	18	dihydrofolate	dihydrofolate	NNP
cord-001835-0s7ok4uw	2702	19	reductase	reductase	NNP
cord-001835-0s7ok4uw	2702	20	(	(	-LRB-
cord-001835-0s7ok4uw	2702	21	DHFR	DHFR	NNP
cord-001835-0s7ok4uw	2702	22	)	)	-RRB-
cord-001835-0s7ok4uw	2702	23	from	from	IN
cord-001835-0s7ok4uw	2702	24	Haloferax	Haloferax	NNP
cord-001835-0s7ok4uw	2702	25	volcanii	volcanii	NNP
cord-001835-0s7ok4uw	2702	26	(	(	-LRB-
cord-001835-0s7ok4uw	2702	27	hvDHFR	hvDHFR	NNP
cord-001835-0s7ok4uw	2702	28	)	)	-RRB-
cord-001835-0s7ok4uw	2702	29	.	.	.
cord-001835-0s7ok4uw	2703	1	DHFR	DHFR	NNP
cord-001835-0s7ok4uw	2703	2	is	be	VBZ
cord-001835-0s7ok4uw	2703	3	a	a	DT
cord-001835-0s7ok4uw	2703	4	very	very	RB
cord-001835-0s7ok4uw	2703	5	well	well	RB
cord-001835-0s7ok4uw	2703	6	understood	understand	VBN
cord-001835-0s7ok4uw	2703	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2703	8	and	and	CC
cord-001835-0s7ok4uw	2703	9	known	know	VBN
cord-001835-0s7ok4uw	2703	10	to	to	TO
cord-001835-0s7ok4uw	2703	11	bound	bind	VBN
cord-001835-0s7ok4uw	2703	12	variety	variety	NN
cord-001835-0s7ok4uw	2703	13	of	of	IN
cord-001835-0s7ok4uw	2703	14	ligands	ligand	NNS
cord-001835-0s7ok4uw	2703	15	that	that	WDT
cord-001835-0s7ok4uw	2703	16	can	can	MD
cord-001835-0s7ok4uw	2703	17	modulate	modulate	VB
cord-001835-0s7ok4uw	2703	18	the	the	DT
cord-001835-0s7ok4uw	2703	19	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2703	20	and	and	CC
cord-001835-0s7ok4uw	2703	21	the	the	DT
cord-001835-0s7ok4uw	2703	22	energy	energy	NN
cord-001835-0s7ok4uw	2703	23	landscapes	landscape	NNS
cord-001835-0s7ok4uw	2703	24	of	of	IN
cord-001835-0s7ok4uw	2703	25	the	the	DT
cord-001835-0s7ok4uw	2703	26	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2703	27	[	[	-LRB-
cord-001835-0s7ok4uw	2703	28	3	3	CD
cord-001835-0s7ok4uw	2703	29	]	]	-RRB-
cord-001835-0s7ok4uw	2703	30	.	.	.
cord-001835-0s7ok4uw	2704	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2704	2	have	have	VBP
cord-001835-0s7ok4uw	2704	3	probed	probe	VBN
cord-001835-0s7ok4uw	2704	4	the	the	DT
cord-001835-0s7ok4uw	2704	5	ls	ls	NNP
cord-001835-0s7ok4uw	2704	6	-	-	HYPH
cord-001835-0s7ok4uw	2704	7	ms	ms	NNP
cord-001835-0s7ok4uw	2704	8	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2704	9	of	of	IN
cord-001835-0s7ok4uw	2704	10	hvDHFR	hvDHFR	NNP
cord-001835-0s7ok4uw	2704	11	bound	bind	VBN
cord-001835-0s7ok4uw	2704	12	to	to	IN
cord-001835-0s7ok4uw	2704	13	the	the	DT
cord-001835-0s7ok4uw	2704	14	cofactor	cofactor	NN
cord-001835-0s7ok4uw	2704	15	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2704	16	(	(	-LRB-
cord-001835-0s7ok4uw	2704	17	holoenzyme	holoenzyme	NNP
cord-001835-0s7ok4uw	2704	18	)	)	-RRB-
cord-001835-0s7ok4uw	2704	19	and	and	CC
cord-001835-0s7ok4uw	2704	20	other	other	JJ
cord-001835-0s7ok4uw	2704	21	substrates	substrate	NNS
cord-001835-0s7ok4uw	2704	22	(	(	-LRB-
cord-001835-0s7ok4uw	2704	23	DHF	DHF	NNP
cord-001835-0s7ok4uw	2704	24	,	,	,
cord-001835-0s7ok4uw	2704	25	THF	THF	NNP
cord-001835-0s7ok4uw	2704	26	)	)	-RRB-
cord-001835-0s7ok4uw	2704	27	using	use	VBG
cord-001835-0s7ok4uw	2704	28	relaxation	relaxation	NN
cord-001835-0s7ok4uw	2704	29	dispersion	dispersion	NN
cord-001835-0s7ok4uw	2704	30	NMR	NMR	NNP
cord-001835-0s7ok4uw	2704	31	.	.	.
cord-001835-0s7ok4uw	2705	1	In	in	IN
cord-001835-0s7ok4uw	2705	2	order	order	NN
cord-001835-0s7ok4uw	2705	3	to	to	TO
cord-001835-0s7ok4uw	2705	4	understand	understand	VB
cord-001835-0s7ok4uw	2705	5	the	the	DT
cord-001835-0s7ok4uw	2705	6	salt	salt	NN
cord-001835-0s7ok4uw	2705	7	contribution	contribution	NN
cord-001835-0s7ok4uw	2705	8	to	to	IN
cord-001835-0s7ok4uw	2705	9	the	the	DT
cord-001835-0s7ok4uw	2705	10	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2705	11	and	and	CC
cord-001835-0s7ok4uw	2705	12	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2705	13	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2705	14	,	,	,
cord-001835-0s7ok4uw	2705	15	the	the	DT
cord-001835-0s7ok4uw	2705	16	experiments	experiment	NNS
cord-001835-0s7ok4uw	2705	17	were	be	VBD
cord-001835-0s7ok4uw	2705	18	done	do	VBN
cord-001835-0s7ok4uw	2705	19	in	in	IN
cord-001835-0s7ok4uw	2705	20	the	the	DT
cord-001835-0s7ok4uw	2705	21	increasing	increase	VBG
cord-001835-0s7ok4uw	2705	22	order	order	NN
cord-001835-0s7ok4uw	2705	23	of	of	IN
cord-001835-0s7ok4uw	2705	24	salt	salt	NN
cord-001835-0s7ok4uw	2705	25	concentration	concentration	NN
cord-001835-0s7ok4uw	2705	26	,	,	,
cord-001835-0s7ok4uw	2705	27	shedding	shed	VBG
cord-001835-0s7ok4uw	2705	28	light	light	NN
cord-001835-0s7ok4uw	2705	29	on	on	IN
cord-001835-0s7ok4uw	2705	30	the	the	DT
cord-001835-0s7ok4uw	2705	31	conformational	conformational	JJ
cord-001835-0s7ok4uw	2705	32	ensembles	ensemble	NNS
cord-001835-0s7ok4uw	2705	33	involved	involve	VBN
cord-001835-0s7ok4uw	2705	34	in	in	IN
cord-001835-0s7ok4uw	2705	35	the	the	DT
cord-001835-0s7ok4uw	2705	36	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2705	37	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2705	38	.	.	.
cord-001835-0s7ok4uw	2706	1	The	the	DT
cord-001835-0s7ok4uw	2706	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	2706	3	relaxation	relaxation	NN
cord-001835-0s7ok4uw	2706	4	dispersion	dispersion	NN
cord-001835-0s7ok4uw	2706	5	analysis	analysis	NN
cord-001835-0s7ok4uw	2706	6	of	of	IN
cord-001835-0s7ok4uw	2706	7	different	different	JJ
cord-001835-0s7ok4uw	2706	8	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2706	9	complexes	complex	NNS
cord-001835-0s7ok4uw	2706	10	in	in	IN
cord-001835-0s7ok4uw	2706	11	the	the	DT
cord-001835-0s7ok4uw	2706	12	presence	presence	NN
cord-001835-0s7ok4uw	2706	13	of	of	IN
cord-001835-0s7ok4uw	2706	14	3	3	CD
cord-001835-0s7ok4uw	2706	15	M	M	NNP
cord-001835-0s7ok4uw	2706	16	and	and	CC
cord-001835-0s7ok4uw	2706	17	2	2	CD
cord-001835-0s7ok4uw	2706	18	M	M	NNP
cord-001835-0s7ok4uw	2706	19	KCl	KCl	NNP
cord-001835-0s7ok4uw	2706	20	has	have	VBZ
cord-001835-0s7ok4uw	2706	21	shown	show	VBN
cord-001835-0s7ok4uw	2706	22	more	more	RBR
cord-001835-0s7ok4uw	2706	23	conformational	conformational	JJ
cord-001835-0s7ok4uw	2706	24	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	2706	25	than	than	IN
cord-001835-0s7ok4uw	2706	26	compared	compare	VBN
cord-001835-0s7ok4uw	2706	27	to	to	IN
cord-001835-0s7ok4uw	2706	28	the	the	DT
cord-001835-0s7ok4uw	2706	29	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2706	30	with	with	IN
cord-001835-0s7ok4uw	2706	31	1	1	CD
cord-001835-0s7ok4uw	2706	32	M	M	NNP
cord-001835-0s7ok4uw	2706	33	KCl	KCl	NNS
cord-001835-0s7ok4uw	2706	34	.	.	.
cord-001835-0s7ok4uw	2707	1	This	this	DT
cord-001835-0s7ok4uw	2707	2	result	result	NN
cord-001835-0s7ok4uw	2707	3	suggests	suggest	VBZ
cord-001835-0s7ok4uw	2707	4	that	that	IN
cord-001835-0s7ok4uw	2707	5	the	the	DT
cord-001835-0s7ok4uw	2707	6	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2707	7	preferably	preferably	RB
cord-001835-0s7ok4uw	2707	8	is	be	VBZ
cord-001835-0s7ok4uw	2707	9	highly	highly	RB
cord-001835-0s7ok4uw	2707	10	active	active	JJ
cord-001835-0s7ok4uw	2707	11	&	&	CC
cord-001835-0s7ok4uw	2707	12	samples	sample	NNS
cord-001835-0s7ok4uw	2707	13	more	more	RBR
cord-001835-0s7ok4uw	2707	14	flexible	flexible	JJ
cord-001835-0s7ok4uw	2707	15	conformers	conformer	NNS
cord-001835-0s7ok4uw	2707	16	in	in	IN
cord-001835-0s7ok4uw	2707	17	the	the	DT
cord-001835-0s7ok4uw	2707	18	hypersaline	hypersaline	JJ
cord-001835-0s7ok4uw	2707	19	environment	environment	NN
cord-001835-0s7ok4uw	2707	20	.	.	.
cord-001835-0s7ok4uw	2708	1	Further	further	RB
cord-001835-0s7ok4uw	2708	2	,	,	,
cord-001835-0s7ok4uw	2708	3	quantification	quantification	NN
cord-001835-0s7ok4uw	2708	4	of	of	IN
cord-001835-0s7ok4uw	2708	5	these	these	DT
cord-001835-0s7ok4uw	2708	6	conformers	conformer	NNS
cord-001835-0s7ok4uw	2708	7	/	/	SYM
cord-001835-0s7ok4uw	2708	8	invisible	invisible	JJ
cord-001835-0s7ok4uw	2708	9	-	-	HYPH
cord-001835-0s7ok4uw	2708	10	states	state	NNS
cord-001835-0s7ok4uw	2708	11	and	and	CC
cord-001835-0s7ok4uw	2708	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2708	13	salt	salt	NN
cord-001835-0s7ok4uw	2708	14	-	-	HYPH
cord-001835-0s7ok4uw	2708	15	dependence	dependence	NN
cord-001835-0s7ok4uw	2708	16	will	will	MD
cord-001835-0s7ok4uw	2708	17	provide	provide	VB
cord-001835-0s7ok4uw	2708	18	new	new	JJ
cord-001835-0s7ok4uw	2708	19	insights	insight	NNS
cord-001835-0s7ok4uw	2708	20	into	into	IN
cord-001835-0s7ok4uw	2708	21	the	the	DT
cord-001835-0s7ok4uw	2708	22	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2708	23	of	of	IN
cord-001835-0s7ok4uw	2708	24	the	the	DT
cord-001835-0s7ok4uw	2708	25	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2708	26	-	-	HYPH
cord-001835-0s7ok4uw	2708	27	catalysis	catalysis	NN
cord-001835-0s7ok4uw	2708	28	.	.	.
cord-001835-0s7ok4uw	2709	1	Also	also	RB
cord-001835-0s7ok4uw	2709	2	,	,	,
cord-001835-0s7ok4uw	2709	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	2709	4	will	will	MD
cord-001835-0s7ok4uw	2709	5	facilitate	facilitate	VB
cord-001835-0s7ok4uw	2709	6	designing	design	VBG
cord-001835-0s7ok4uw	2709	7	novel	novel	JJ
cord-001835-0s7ok4uw	2709	8	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	2709	9	that	that	WDT
cord-001835-0s7ok4uw	2709	10	can	can	MD
cord-001835-0s7ok4uw	2709	11	be	be	VB
cord-001835-0s7ok4uw	2709	12	used	use	VBN
cord-001835-0s7ok4uw	2709	13	in	in	IN
cord-001835-0s7ok4uw	2709	14	the	the	DT
cord-001835-0s7ok4uw	2709	15	bioprocess	bioprocess	NN
cord-001835-0s7ok4uw	2709	16	industrial	industrial	JJ
cord-001835-0s7ok4uw	2709	17	set	set	NN
cord-001835-0s7ok4uw	2709	18	-	-	HYPH
cord-001835-0s7ok4uw	2709	19	up	up	NN
cord-001835-0s7ok4uw	2709	20	under	under	IN
cord-001835-0s7ok4uw	2709	21	extreme	extreme	JJ
cord-001835-0s7ok4uw	2709	22	conditions	condition	NNS
cord-001835-0s7ok4uw	2709	23	.	.	.
cord-001835-0s7ok4uw	2710	1	1	1	LS
cord-001835-0s7ok4uw	2710	2	.	.	.
cord-001835-0s7ok4uw	2711	1	Tadeo	Tadeo	NNP
cord-001835-0s7ok4uw	2711	2	 	 	_SP
cord-001835-0s7ok4uw	2712	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2712	2	have	have	VBP
cord-001835-0s7ok4uw	2712	3	identified	identify	VBN
cord-001835-0s7ok4uw	2712	4	the	the	DT
cord-001835-0s7ok4uw	2712	5	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	2712	6	protein	protein	NN
cord-001835-0s7ok4uw	2712	7	HbpS	HbpS	NNP
cord-001835-0s7ok4uw	2712	8	in	in	IN
cord-001835-0s7ok4uw	2712	9	the	the	DT
cord-001835-0s7ok4uw	2712	10	cellulose	cellulose	NN
cord-001835-0s7ok4uw	2712	11	degrader	degrader	NN
cord-001835-0s7ok4uw	2712	12	Streptomyces	Streptomyces	NNP
cord-001835-0s7ok4uw	2712	13	reticuli	reticuli	NNS
cord-001835-0s7ok4uw	2712	14	and	and	CC
cord-001835-0s7ok4uw	2712	15	shown	show	VBN
cord-001835-0s7ok4uw	2712	16	that	that	IN
cord-001835-0s7ok4uw	2712	17	it	-PRON-	PRP
cord-001835-0s7ok4uw	2712	18	specifically	specifically	RB
cord-001835-0s7ok4uw	2712	19	binds	bind	VBZ
cord-001835-0s7ok4uw	2712	20	iron	iron	NN
cord-001835-0s7ok4uw	2712	21	ions	ion	NNS
cord-001835-0s7ok4uw	2712	22	,	,	,
cord-001835-0s7ok4uw	2712	23	heme	heme	NNP
cord-001835-0s7ok4uw	2712	24	and	and	CC
cord-001835-0s7ok4uw	2712	25	aquo	aquo	NN
cord-001835-0s7ok4uw	2712	26	-	-	HYPH
cord-001835-0s7ok4uw	2712	27	cobalamin	cobalamin	NN
cord-001835-0s7ok4uw	2712	28	.	.	.
cord-001835-0s7ok4uw	2713	1	Based	base	VBN
cord-001835-0s7ok4uw	2713	2	on	on	IN
cord-001835-0s7ok4uw	2713	3	3D	3D	NNP
cord-001835-0s7ok4uw	2713	4	crystal	crystal	NN
cord-001835-0s7ok4uw	2713	5	structures	structure	NNS
cord-001835-0s7ok4uw	2713	6	,	,	,
cord-001835-0s7ok4uw	2713	7	structural	structural	JJ
cord-001835-0s7ok4uw	2713	8	alignments	alignment	NNS
cord-001835-0s7ok4uw	2713	9	,	,	,
cord-001835-0s7ok4uw	2713	10	sequence	sequence	NN
cord-001835-0s7ok4uw	2713	11	comparisons	comparison	NNS
cord-001835-0s7ok4uw	2713	12	,	,	,
cord-001835-0s7ok4uw	2713	13	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	2713	14	,	,	,
cord-001835-0s7ok4uw	2713	15	and	and	CC
cord-001835-0s7ok4uw	2713	16	comparative	comparative	JJ
cord-001835-0s7ok4uw	2713	17	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	2713	18	investigations	investigation	NNS
cord-001835-0s7ok4uw	2713	19	,	,	,
cord-001835-0s7ok4uw	2713	20	we	-PRON-	PRP
cord-001835-0s7ok4uw	2713	21	identified	identify	VBD
cord-001835-0s7ok4uw	2713	22	the	the	DT
cord-001835-0s7ok4uw	2713	23	coordination	coordination	NN
cord-001835-0s7ok4uw	2713	24	sites	site	NNS
cord-001835-0s7ok4uw	2713	25	for	for	IN
cord-001835-0s7ok4uw	2713	26	iron	iron	NN
cord-001835-0s7ok4uw	2713	27	,	,	,
cord-001835-0s7ok4uw	2713	28	heme	heme	NNP
cord-001835-0s7ok4uw	2713	29	and	and	CC
cord-001835-0s7ok4uw	2713	30	aquo	aquo	NNP
cord-001835-0s7ok4uw	2713	31	-	-	HYPH
cord-001835-0s7ok4uw	2713	32	cobalamin	cobalamin	NN
cord-001835-0s7ok4uw	2713	33	,	,	,
cord-001835-0s7ok4uw	2713	34	and	and	CC
cord-001835-0s7ok4uw	2713	35	binding	bind	VBG
cord-001835-0s7ok4uw	2713	36	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2713	37	were	be	VBD
cord-001835-0s7ok4uw	2713	38	elucidated	elucidate	VBN
cord-001835-0s7ok4uw	2713	39	[	[	-LRB-
cord-001835-0s7ok4uw	2713	40	1	1	CD
cord-001835-0s7ok4uw	2713	41	,	,	,
cord-001835-0s7ok4uw	2713	42	2	2	CD
cord-001835-0s7ok4uw	2713	43	]	]	-RRB-
cord-001835-0s7ok4uw	2713	44	.	.	.
cord-001835-0s7ok4uw	2714	1	HbpS	HbpS	NNP
cord-001835-0s7ok4uw	2714	2	interacts	interact	VBZ
cord-001835-0s7ok4uw	2714	3	with	with	IN
cord-001835-0s7ok4uw	2714	4	the	the	DT
cord-001835-0s7ok4uw	2714	5	membrane	membrane	NN
cord-001835-0s7ok4uw	2714	6	-	-	HYPH
cord-001835-0s7ok4uw	2714	7	embedded	embed	VBN
cord-001835-0s7ok4uw	2714	8	sensor	sensor	NN
cord-001835-0s7ok4uw	2714	9	kinase	kinase	NN
cord-001835-0s7ok4uw	2714	10	SenS.	SenS.	NNP
cord-001835-0s7ok4uw	2715	1	While	while	IN
cord-001835-0s7ok4uw	2715	2	under	under	IN
cord-001835-0s7ok4uw	2715	3	nonstressed	nonstressed	JJ
cord-001835-0s7ok4uw	2715	4	conditions	condition	NNS
cord-001835-0s7ok4uw	2715	5	HbpS	HbpS	NNP
cord-001835-0s7ok4uw	2715	6	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	2715	7	SenS	SenS	NNP
cord-001835-0s7ok4uw	2715	8	autophosphorylation	autophosphorylation	NN
cord-001835-0s7ok4uw	2715	9	,	,	,
cord-001835-0s7ok4uw	2715	10	under	under	IN
cord-001835-0s7ok4uw	2715	11	oxidative	oxidative	NN
cord-001835-0s7ok4uw	2715	12	-	-	HYPH
cord-001835-0s7ok4uw	2715	13	stressing	stress	VBG
cord-001835-0s7ok4uw	2715	14	conditions	condition	NNS
cord-001835-0s7ok4uw	2715	15	activates	activate	VBZ
cord-001835-0s7ok4uw	2715	16	it	-PRON-	PRP
cord-001835-0s7ok4uw	2715	17	.	.	.
cord-001835-0s7ok4uw	2716	1	SenS	SenS	NNP
cord-001835-0s7ok4uw	2716	2	in	in	IN
cord-001835-0s7ok4uw	2716	3	turn	turn	NN
cord-001835-0s7ok4uw	2716	4	phosphorylates	phosphorylate	VBZ
cord-001835-0s7ok4uw	2716	5	the	the	DT
cord-001835-0s7ok4uw	2716	6	response	response	NN
cord-001835-0s7ok4uw	2716	7	regulator	regulator	NN
cord-001835-0s7ok4uw	2716	8	SenR	SenR	NNP
cord-001835-0s7ok4uw	2716	9	that	that	WDT
cord-001835-0s7ok4uw	2716	10	activates	activate	VBZ
cord-001835-0s7ok4uw	2716	11	the	the	DT
cord-001835-0s7ok4uw	2716	12	transcription	transcription	NN
cord-001835-0s7ok4uw	2716	13	of	of	IN
cord-001835-0s7ok4uw	2716	14	anti	anti	JJ
cord-001835-0s7ok4uw	2716	15	-	-	JJ
cord-001835-0s7ok4uw	2716	16	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	2716	17	genes	gene	NNS
cord-001835-0s7ok4uw	2716	18	[	[	-LRB-
cord-001835-0s7ok4uw	2716	19	3	3	CD
cord-001835-0s7ok4uw	2716	20	]	]	-RRB-
cord-001835-0s7ok4uw	2716	21	.	.	.
cord-001835-0s7ok4uw	2717	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2717	2	crystallized	crystallize	VBD
cord-001835-0s7ok4uw	2717	3	HbpS	HbpS	NNP
cord-001835-0s7ok4uw	2717	4	and	and	CC
cord-001835-0s7ok4uw	2717	5	solved	solve	VBD
cord-001835-0s7ok4uw	2717	6	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2717	7	3D	3d	JJ
cord-001835-0s7ok4uw	2717	8	crystal	crystal	NN
cord-001835-0s7ok4uw	2717	9	structure	structure	NN
cord-001835-0s7ok4uw	2717	10	that	that	WDT
cord-001835-0s7ok4uw	2717	11	revealed	reveal	VBD
cord-001835-0s7ok4uw	2717	12	an	an	DT
cord-001835-0s7ok4uw	2717	13	octomeric	octomeric	JJ
cord-001835-0s7ok4uw	2717	14	assembly	assembly	NN
cord-001835-0s7ok4uw	2717	15	which	which	WDT
cord-001835-0s7ok4uw	2717	16	is	be	VBZ
cord-001835-0s7ok4uw	2717	17	required	require	VBN
cord-001835-0s7ok4uw	2717	18	for	for	IN
cord-001835-0s7ok4uw	2717	19	interaction	interaction	NN
cord-001835-0s7ok4uw	2717	20	with	with	IN
cord-001835-0s7ok4uw	2717	21	SenS	SenS	NNP
cord-001835-0s7ok4uw	2717	22	[	[	-LRB-
cord-001835-0s7ok4uw	2717	23	4	4	CD
cord-001835-0s7ok4uw	2717	24	]	]	-RRB-
cord-001835-0s7ok4uw	2717	25	.	.	.
cord-001835-0s7ok4uw	2718	1	Using	use	VBG
cord-001835-0s7ok4uw	2718	2	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	2718	3	,	,	,
cord-001835-0s7ok4uw	2718	4	FRET	fret	NN
cord-001835-0s7ok4uw	2718	5	,	,	,
cord-001835-0s7ok4uw	2718	6	CD	cd	NN
cord-001835-0s7ok4uw	2718	7	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2718	8	,	,	,
cord-001835-0s7ok4uw	2718	9	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2718	10	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2718	11	and	and	CC
cord-001835-0s7ok4uw	2718	12	site	site	NN
cord-001835-0s7ok4uw	2718	13	-	-	HYPH
cord-001835-0s7ok4uw	2718	14	directed	direct	VBN
cord-001835-0s7ok4uw	2718	15	spin	spin	NN
cord-001835-0s7ok4uw	2718	16	labelling	labelling	NN
cord-001835-0s7ok4uw	2718	17	combined	combine	VBN
cord-001835-0s7ok4uw	2718	18	with	with	IN
cord-001835-0s7ok4uw	2718	19	pulse	pulse	NN
cord-001835-0s7ok4uw	2718	20	electron	electron	NN
cord-001835-0s7ok4uw	2718	21	paramagnetic	paramagnetic	JJ
cord-001835-0s7ok4uw	2718	22	resonance	resonance	NN
cord-001835-0s7ok4uw	2718	23	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	2718	24	,	,	,
cord-001835-0s7ok4uw	2718	25	we	-PRON-	PRP
cord-001835-0s7ok4uw	2718	26	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	2718	27	that	that	IN
cord-001835-0s7ok4uw	2718	28	ironmediated	ironmediate	VBN
cord-001835-0s7ok4uw	2718	29	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	2718	30	stress	stress	NN
cord-001835-0s7ok4uw	2718	31	induces	induce	VBZ
cord-001835-0s7ok4uw	2718	32	both	both	DT
cord-001835-0s7ok4uw	2718	33	secondary	secondary	JJ
cord-001835-0s7ok4uw	2718	34	structure	structure	NN
cord-001835-0s7ok4uw	2718	35	and	and	CC
cord-001835-0s7ok4uw	2718	36	overall	overall	JJ
cord-001835-0s7ok4uw	2718	37	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	2718	38	conformational	conformational	JJ
cord-001835-0s7ok4uw	2718	39	changes	change	NNS
cord-001835-0s7ok4uw	2718	40	within	within	IN
cord-001835-0s7ok4uw	2718	41	HbpS.	hbps.	NN
cord-001835-0s7ok4uw	2719	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2719	2	additionally	additionally	RB
cord-001835-0s7ok4uw	2719	3	showed	show	VBD
cord-001835-0s7ok4uw	2719	4	that	that	IN
cord-001835-0s7ok4uw	2719	5	HbpS	HbpS	NNP
cord-001835-0s7ok4uw	2719	6	is	be	VBZ
cord-001835-0s7ok4uw	2719	7	oxidatively	oxidatively	RB
cord-001835-0s7ok4uw	2719	8	modified	modify	VBN
cord-001835-0s7ok4uw	2719	9	,	,	,
cord-001835-0s7ok4uw	2719	10	leading	lead	VBG
cord-001835-0s7ok4uw	2719	11	to	to	IN
cord-001835-0s7ok4uw	2719	12	the	the	DT
cord-001835-0s7ok4uw	2719	13	generation	generation	NN
cord-001835-0s7ok4uw	2719	14	of	of	IN
cord-001835-0s7ok4uw	2719	15	highly	highly	RB
cord-001835-0s7ok4uw	2719	16	reactive	reactive	JJ
cord-001835-0s7ok4uw	2719	17	carbonyl	carbonyl	NN
cord-001835-0s7ok4uw	2719	18	groups	group	NNS
cord-001835-0s7ok4uw	2719	19	and	and	CC
cord-001835-0s7ok4uw	2719	20	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	2719	21	-	-	HYPH
cord-001835-0s7ok4uw	2719	22	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	2719	23	bonds	bond	NNS
cord-001835-0s7ok4uw	2719	24	[	[	-LRB-
cord-001835-0s7ok4uw	2719	25	5	5	CD
cord-001835-0s7ok4uw	2719	26	]	]	-RRB-
cord-001835-0s7ok4uw	2719	27	.	.	.
cord-001835-0s7ok4uw	2720	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2720	2	concluded	conclude	VBD
cord-001835-0s7ok4uw	2720	3	that	that	IN
cord-001835-0s7ok4uw	2720	4	these	these	DT
cord-001835-0s7ok4uw	2720	5	molecular	molecular	JJ
cord-001835-0s7ok4uw	2720	6	events	event	NNS
cord-001835-0s7ok4uw	2720	7	are	be	VBP
cord-001835-0s7ok4uw	2720	8	responsible	responsible	JJ
cord-001835-0s7ok4uw	2720	9	for	for	IN
cord-001835-0s7ok4uw	2720	10	the	the	DT
cord-001835-0s7ok4uw	2720	11	HbpS	HbpS	NNP
cord-001835-0s7ok4uw	2720	12	-	-	HYPH
cord-001835-0s7ok4uw	2720	13	mediated	mediate	VBN
cord-001835-0s7ok4uw	2720	14	activation	activation	NN
cord-001835-0s7ok4uw	2720	15	of	of	IN
cord-001835-0s7ok4uw	2720	16	the	the	DT
cord-001835-0s7ok4uw	2720	17	sensor	sensor	NN
cord-001835-0s7ok4uw	2720	18	kinase	kinase	NN
cord-001835-0s7ok4uw	2720	19	SenS.	SenS.	NNP
cord-001835-0s7ok4uw	2721	1	This	this	DT
cord-001835-0s7ok4uw	2721	2	presentation	presentation	NN
cord-001835-0s7ok4uw	2721	3	will	will	MD
cord-001835-0s7ok4uw	2721	4	focus	focus	VB
cord-001835-0s7ok4uw	2721	5	on	on	IN
cord-001835-0s7ok4uw	2721	6	the	the	DT
cord-001835-0s7ok4uw	2721	7	HbpS	HbpS	NNP
cord-001835-0s7ok4uw	2721	8	structure	structure	NN
cord-001835-0s7ok4uw	2721	9	and	and	CC
cord-001835-0s7ok4uw	2721	10	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2721	11	within	within	IN
cord-001835-0s7ok4uw	2721	12	the	the	DT
cord-001835-0s7ok4uw	2721	13	protein	protein	NN
cord-001835-0s7ok4uw	2721	14	.	.	.
cord-001835-0s7ok4uw	2722	1	Indian	Indian	NNP
cord-001835-0s7ok4uw	2722	2	Institute	Institute	NNP
cord-001835-0s7ok4uw	2722	3	of	of	IN
cord-001835-0s7ok4uw	2722	4	Technology	Technology	NNP
cord-001835-0s7ok4uw	2722	5	Bombay	Bombay	NNP
cord-001835-0s7ok4uw	2722	6	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2723	1	(	(	-LRB-
cord-001835-0s7ok4uw	2723	2	FOP	fop	NN
cord-001835-0s7ok4uw	2723	3	-	-	HYPH
cord-001835-0s7ok4uw	2723	4	related	relate	VBN
cord-001835-0s7ok4uw	2723	5	protein	protein	NN
cord-001835-0s7ok4uw	2723	6	of	of	IN
cord-001835-0s7ok4uw	2723	7	20	20	CD
cord-001835-0s7ok4uw	2723	8	kDa	kDa	NNP
cord-001835-0s7ok4uw	2723	9	)	)	-RRB-
cord-001835-0s7ok4uw	2723	10	,	,	,
cord-001835-0s7ok4uw	2723	11	a	a	DT
cord-001835-0s7ok4uw	2723	12	centrosomal	centrosomal	JJ
cord-001835-0s7ok4uw	2723	13	protein	protein	NN
cord-001835-0s7ok4uw	2723	14	,	,	,
cord-001835-0s7ok4uw	2723	15	is	be	VBZ
cord-001835-0s7ok4uw	2723	16	conserved	conserve	VBN
cord-001835-0s7ok4uw	2723	17	across	across	IN
cord-001835-0s7ok4uw	2723	18	all	all	DT
cord-001835-0s7ok4uw	2723	19	ciliated	ciliated	JJ
cord-001835-0s7ok4uw	2723	20	eukaryotes	eukaryote	NNS
cord-001835-0s7ok4uw	2723	21	.	.	.
cord-001835-0s7ok4uw	2724	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2724	2	has	have	VBZ
cord-001835-0s7ok4uw	2724	3	been	be	VBN
cord-001835-0s7ok4uw	2724	4	shown	show	VBN
cord-001835-0s7ok4uw	2724	5	to	to	TO
cord-001835-0s7ok4uw	2724	6	be	be	VB
cord-001835-0s7ok4uw	2724	7	involved	involve	VBN
cord-001835-0s7ok4uw	2724	8	in	in	IN
cord-001835-0s7ok4uw	2724	9	ciliogenesis	ciliogenesis	NNP
cord-001835-0s7ok4uw	2724	10	in	in	IN
cord-001835-0s7ok4uw	2724	11	RPE	RPE	NNP
cord-001835-0s7ok4uw	2724	12	cells	cell	NNS
cord-001835-0s7ok4uw	2724	13	and	and	CC
cord-001835-0s7ok4uw	2724	14	in	in	IN
cord-001835-0s7ok4uw	2724	15	the	the	DT
cord-001835-0s7ok4uw	2724	16	S	s	NN
cord-001835-0s7ok4uw	2724	17	-	-	HYPH
cord-001835-0s7ok4uw	2724	18	phase	phase	NN
cord-001835-0s7ok4uw	2724	19	progression	progression	NN
cord-001835-0s7ok4uw	2724	20	in	in	IN
cord-001835-0s7ok4uw	2724	21	HeLa	HeLa	NNP
cord-001835-0s7ok4uw	2724	22	cells	cell	NNS
cord-001835-0s7ok4uw	2724	23	.	.	.
cord-001835-0s7ok4uw	2725	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2725	2	localizes	localize	VBZ
cord-001835-0s7ok4uw	2725	3	to	to	IN
cord-001835-0s7ok4uw	2725	4	the	the	DT
cord-001835-0s7ok4uw	2725	5	pericentriolar	pericentriolar	NNP
cord-001835-0s7ok4uw	2725	6	satellite	satellite	NNP
cord-001835-0s7ok4uw	2725	7	and	and	CC
cord-001835-0s7ok4uw	2725	8	at	at	IN
cord-001835-0s7ok4uw	2725	9	the	the	DT
cord-001835-0s7ok4uw	2725	10	centrosome	centrosome	NN
cord-001835-0s7ok4uw	2725	11	.	.	.
cord-001835-0s7ok4uw	2726	1	The	the	DT
cord-001835-0s7ok4uw	2726	2	localization	localization	NN
cord-001835-0s7ok4uw	2726	3	of	of	IN
cord-001835-0s7ok4uw	2726	4	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2726	5	at	at	IN
cord-001835-0s7ok4uw	2726	6	the	the	DT
cord-001835-0s7ok4uw	2726	7	centrosome	centrosome	NN
cord-001835-0s7ok4uw	2726	8	has	have	VBZ
cord-001835-0s7ok4uw	2726	9	been	be	VBN
cord-001835-0s7ok4uw	2726	10	found	find	VBN
cord-001835-0s7ok4uw	2726	11	to	to	TO
cord-001835-0s7ok4uw	2726	12	be	be	VB
cord-001835-0s7ok4uw	2726	13	throughout	throughout	IN
cord-001835-0s7ok4uw	2726	14	the	the	DT
cord-001835-0s7ok4uw	2726	15	cell	cell	NN
cord-001835-0s7ok4uw	2726	16	cycle	cycle	NN
cord-001835-0s7ok4uw	2726	17	.	.	.
cord-001835-0s7ok4uw	2727	1	In	in	IN
cord-001835-0s7ok4uw	2727	2	Paramecium	Paramecium	NNP
cord-001835-0s7ok4uw	2727	3	,	,	,
cord-001835-0s7ok4uw	2727	4	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2727	5	is	be	VBZ
cord-001835-0s7ok4uw	2727	6	involved	involve	VBN
cord-001835-0s7ok4uw	2727	7	in	in	IN
cord-001835-0s7ok4uw	2727	8	docking	docking	NN
cord-001835-0s7ok4uw	2727	9	of	of	IN
cord-001835-0s7ok4uw	2727	10	the	the	DT
cord-001835-0s7ok4uw	2727	11	basal	basal	NN
cord-001835-0s7ok4uw	2727	12	body	body	NN
cord-001835-0s7ok4uw	2727	13	to	to	IN
cord-001835-0s7ok4uw	2727	14	the	the	DT
cord-001835-0s7ok4uw	2727	15	cell	cell	NN
cord-001835-0s7ok4uw	2727	16	membrane	membrane	NN
cord-001835-0s7ok4uw	2727	17	and	and	CC
cord-001835-0s7ok4uw	2727	18	in	in	IN
cord-001835-0s7ok4uw	2727	19	the	the	DT
cord-001835-0s7ok4uw	2727	20	assembly	assembly	NN
cord-001835-0s7ok4uw	2727	21	of	of	IN
cord-001835-0s7ok4uw	2727	22	the	the	DT
cord-001835-0s7ok4uw	2727	23	transition	transition	NN
cord-001835-0s7ok4uw	2727	24	zone	zone	NN
cord-001835-0s7ok4uw	2727	25	.	.	.
cord-001835-0s7ok4uw	2728	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2728	2	found	find	VBD
cord-001835-0s7ok4uw	2728	3	that	that	IN
cord-001835-0s7ok4uw	2728	4	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2728	5	colocalizes	colocalizes	NNP
cord-001835-0s7ok4uw	2728	6	with	with	IN
cord-001835-0s7ok4uw	2728	7	ciliated	ciliated	JJ
cord-001835-0s7ok4uw	2728	8	microtubules	microtubule	NNS
cord-001835-0s7ok4uw	2728	9	in	in	IN
cord-001835-0s7ok4uw	2728	10	NIH3T3	NIH3T3	NNP
cord-001835-0s7ok4uw	2728	11	cells	cell	NNS
cord-001835-0s7ok4uw	2728	12	.	.	.
cord-001835-0s7ok4uw	2729	1	Since	since	IN
cord-001835-0s7ok4uw	2729	2	,	,	,
cord-001835-0s7ok4uw	2729	3	the	the	DT
cord-001835-0s7ok4uw	2729	4	localization	localization	NN
cord-001835-0s7ok4uw	2729	5	of	of	IN
cord-001835-0s7ok4uw	2729	6	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2729	7	to	to	IN
cord-001835-0s7ok4uw	2729	8	the	the	DT
cord-001835-0s7ok4uw	2729	9	pericentriolar	pericentriolar	NNP
cord-001835-0s7ok4uw	2729	10	satellite	satellite	NNP
cord-001835-0s7ok4uw	2729	11	is	be	VBZ
cord-001835-0s7ok4uw	2729	12	dependent	dependent	JJ
cord-001835-0s7ok4uw	2729	13	on	on	IN
cord-001835-0s7ok4uw	2729	14	microtubules	microtubule	NNS
cord-001835-0s7ok4uw	2729	15	and	and	CC
cord-001835-0s7ok4uw	2729	16	the	the	DT
cord-001835-0s7ok4uw	2729	17	cilium	cilium	NN
cord-001835-0s7ok4uw	2729	18	itself	-PRON-	PRP
cord-001835-0s7ok4uw	2729	19	is	be	VBZ
cord-001835-0s7ok4uw	2729	20	a	a	DT
cord-001835-0s7ok4uw	2729	21	microtubule	microtubule	NN
cord-001835-0s7ok4uw	2729	22	-	-	HYPH
cord-001835-0s7ok4uw	2729	23	based	base	VBN
cord-001835-0s7ok4uw	2729	24	structure	structure	NN
cord-001835-0s7ok4uw	2729	25	;	;	:
cord-001835-0s7ok4uw	2729	26	we	-PRON-	PRP
cord-001835-0s7ok4uw	2729	27	sought	seek	VBD
cord-001835-0s7ok4uw	2729	28	to	to	TO
cord-001835-0s7ok4uw	2729	29	investigate	investigate	VB
cord-001835-0s7ok4uw	2729	30	the	the	DT
cord-001835-0s7ok4uw	2729	31	role	role	NN
cord-001835-0s7ok4uw	2729	32	of	of	IN
cord-001835-0s7ok4uw	2729	33	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2729	34	in	in	IN
cord-001835-0s7ok4uw	2729	35	microtubule	microtubule	JJ
cord-001835-0s7ok4uw	2729	36	assembly	assembly	NN
cord-001835-0s7ok4uw	2729	37	.	.	.
cord-001835-0s7ok4uw	2730	1	The	the	DT
cord-001835-0s7ok4uw	2730	2	over	over	IN
cord-001835-0s7ok4uw	2730	3	-	-	HYPH
cord-001835-0s7ok4uw	2730	4	expression	expression	NN
cord-001835-0s7ok4uw	2730	5	of	of	IN
cord-001835-0s7ok4uw	2730	6	GFP	GFP	NNP
cord-001835-0s7ok4uw	2730	7	-	-	HYPH
cord-001835-0s7ok4uw	2730	8	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2730	9	in	in	IN
cord-001835-0s7ok4uw	2730	10	HeLa	HeLa	NNP
cord-001835-0s7ok4uw	2730	11	cells	cell	NNS
cord-001835-0s7ok4uw	2730	12	led	lead	VBD
cord-001835-0s7ok4uw	2730	13	to	to	IN
cord-001835-0s7ok4uw	2730	14	the	the	DT
cord-001835-0s7ok4uw	2730	15	depolymerization	depolymerization	NN
cord-001835-0s7ok4uw	2730	16	of	of	IN
cord-001835-0s7ok4uw	2730	17	microtubules	microtubule	NNS
cord-001835-0s7ok4uw	2730	18	while	while	IN
cord-001835-0s7ok4uw	2730	19	only	only	RB
cord-001835-0s7ok4uw	2730	20	the	the	DT
cord-001835-0s7ok4uw	2730	21	GFP	GFP	NNP
cord-001835-0s7ok4uw	2730	22	expressing	express	VBG
cord-001835-0s7ok4uw	2730	23	HeLa	HeLa	NNP
cord-001835-0s7ok4uw	2730	24	cells	cell	NNS
cord-001835-0s7ok4uw	2730	25	showed	show	VBD
cord-001835-0s7ok4uw	2730	26	typical	typical	JJ
cord-001835-0s7ok4uw	2730	27	microtubule	microtubule	NN
cord-001835-0s7ok4uw	2730	28	network	network	NN
cord-001835-0s7ok4uw	2730	29	.	.	.
cord-001835-0s7ok4uw	2731	1	In	in	IN
cord-001835-0s7ok4uw	2731	2	addition	addition	NN
cord-001835-0s7ok4uw	2731	3	,	,	,
cord-001835-0s7ok4uw	2731	4	the	the	DT
cord-001835-0s7ok4uw	2731	5	microtubules	microtubule	NNS
cord-001835-0s7ok4uw	2731	6	of	of	IN
cord-001835-0s7ok4uw	2731	7	GFP	GFP	NNP
cord-001835-0s7ok4uw	2731	8	-	-	HYPH
cord-001835-0s7ok4uw	2731	9	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2731	10	expressing	express	VBG
cord-001835-0s7ok4uw	2731	11	HeLa	HeLa	NNP
cord-001835-0s7ok4uw	2731	12	cells	cell	NNS
cord-001835-0s7ok4uw	2731	13	were	be	VBD
cord-001835-0s7ok4uw	2731	14	found	find	VBN
cord-001835-0s7ok4uw	2731	15	to	to	TO
cord-001835-0s7ok4uw	2731	16	be	be	VB
cord-001835-0s7ok4uw	2731	17	more	more	RBR
cord-001835-0s7ok4uw	2731	18	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	2731	19	towards	towards	IN
cord-001835-0s7ok4uw	2731	20	nocodazole	nocodazole	NNP
cord-001835-0s7ok4uw	2731	21	,	,	,
cord-001835-0s7ok4uw	2731	22	a	a	DT
cord-001835-0s7ok4uw	2731	23	microtubule	microtubule	NN
cord-001835-0s7ok4uw	2731	24	-	-	HYPH
cord-001835-0s7ok4uw	2731	25	depolymerizing	depolymerize	VBG
cord-001835-0s7ok4uw	2731	26	agent	agent	NN
cord-001835-0s7ok4uw	2731	27	,	,	,
cord-001835-0s7ok4uw	2731	28	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2731	29	that	that	IN
cord-001835-0s7ok4uw	2731	30	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2731	31	destabilizes	destabilize	VBZ
cord-001835-0s7ok4uw	2731	32	microtubules	microtubule	NNS
cord-001835-0s7ok4uw	2731	33	.	.	.
cord-001835-0s7ok4uw	2732	1	The	the	DT
cord-001835-0s7ok4uw	2732	2	effect	effect	NN
cord-001835-0s7ok4uw	2732	3	of	of	IN
cord-001835-0s7ok4uw	2732	4	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2732	5	on	on	IN
cord-001835-0s7ok4uw	2732	6	the	the	DT
cord-001835-0s7ok4uw	2732	7	polymerization	polymerization	NN
cord-001835-0s7ok4uw	2732	8	of	of	IN
cord-001835-0s7ok4uw	2732	9	tubulin	tubulin	NN
cord-001835-0s7ok4uw	2732	10	was	be	VBD
cord-001835-0s7ok4uw	2732	11	monitored	monitor	VBN
cord-001835-0s7ok4uw	2732	12	by	by	IN
cord-001835-0s7ok4uw	2732	13	light	light	JJ
cord-001835-0s7ok4uw	2732	14	scattering	scattering	NN
cord-001835-0s7ok4uw	2732	15	,	,	,
cord-001835-0s7ok4uw	2732	16	sedimentation	sedimentation	NN
cord-001835-0s7ok4uw	2732	17	assay	assay	NN
cord-001835-0s7ok4uw	2732	18	and	and	CC
cord-001835-0s7ok4uw	2732	19	electron	electron	NN
cord-001835-0s7ok4uw	2732	20	microscopy	microscopy	NN
cord-001835-0s7ok4uw	2732	21	.	.	.
cord-001835-0s7ok4uw	2733	1	In	in	IN
cord-001835-0s7ok4uw	2733	2	vitro	vitro	FW
cord-001835-0s7ok4uw	2733	3	,	,	,
cord-001835-0s7ok4uw	2733	4	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2733	5	inhibited	inhibit	VBD
cord-001835-0s7ok4uw	2733	6	the	the	DT
cord-001835-0s7ok4uw	2733	7	rate	rate	NN
cord-001835-0s7ok4uw	2733	8	and	and	CC
cord-001835-0s7ok4uw	2733	9	extent	extent	NN
cord-001835-0s7ok4uw	2733	10	of	of	IN
cord-001835-0s7ok4uw	2733	11	polymerization	polymerization	NN
cord-001835-0s7ok4uw	2733	12	of	of	IN
cord-001835-0s7ok4uw	2733	13	tubulin	tubulin	NN
cord-001835-0s7ok4uw	2733	14	.	.	.
cord-001835-0s7ok4uw	2734	1	For	for	IN
cord-001835-0s7ok4uw	2734	2	example	example	NN
cord-001835-0s7ok4uw	2734	3	,	,	,
cord-001835-0s7ok4uw	2734	4	5	5	CD
cord-001835-0s7ok4uw	2734	5	,	,	,
cord-001835-0s7ok4uw	2734	6	10	10	CD
cord-001835-0s7ok4uw	2734	7	,	,	,
cord-001835-0s7ok4uw	2734	8	15	15	CD
cord-001835-0s7ok4uw	2734	9	and	and	CC
cord-001835-0s7ok4uw	2734	10	20	20	CD
cord-001835-0s7ok4uw	2734	11	mM	mm	CD
cord-001835-0s7ok4uw	2734	12	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2734	13	inhibited	inhibit	VBD
cord-001835-0s7ok4uw	2734	14	the	the	DT
cord-001835-0s7ok4uw	2734	15	polymerization	polymerization	NN
cord-001835-0s7ok4uw	2734	16	of	of	IN
cord-001835-0s7ok4uw	2734	17	purified	purify	VBN
cord-001835-0s7ok4uw	2734	18	tubulin	tubulin	NN
cord-001835-0s7ok4uw	2734	19	by	by	IN
cord-001835-0s7ok4uw	2734	20	11	11	CD
cord-001835-0s7ok4uw	2734	21	,	,	,
cord-001835-0s7ok4uw	2734	22	20	20	CD
cord-001835-0s7ok4uw	2734	23	,	,	,
cord-001835-0s7ok4uw	2734	24	39	39	CD
cord-001835-0s7ok4uw	2734	25	and	and	CC
cord-001835-0s7ok4uw	2734	26	52	52	CD
cord-001835-0s7ok4uw	2734	27	%	%	NN
cord-001835-0s7ok4uw	2734	28	,	,	,
cord-001835-0s7ok4uw	2734	29	respectively	respectively	RB
cord-001835-0s7ok4uw	2734	30	.	.	.
cord-001835-0s7ok4uw	2735	1	Further	further	RB
cord-001835-0s7ok4uw	2735	2	,	,	,
cord-001835-0s7ok4uw	2735	3	the	the	DT
cord-001835-0s7ok4uw	2735	4	sedimentation	sedimentation	NN
cord-001835-0s7ok4uw	2735	5	assay	assay	NN
cord-001835-0s7ok4uw	2735	6	suggested	suggest	VBD
cord-001835-0s7ok4uw	2735	7	that	that	IN
cord-001835-0s7ok4uw	2735	8	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2735	9	inhibited	inhibit	VBD
cord-001835-0s7ok4uw	2735	10	the	the	DT
cord-001835-0s7ok4uw	2735	11	polymerization	polymerization	NN
cord-001835-0s7ok4uw	2735	12	of	of	IN
cord-001835-0s7ok4uw	2735	13	tubulin	tubulin	NN
cord-001835-0s7ok4uw	2735	14	.	.	.
cord-001835-0s7ok4uw	2736	1	In	in	IN
cord-001835-0s7ok4uw	2736	2	addition	addition	NN
cord-001835-0s7ok4uw	2736	3	,	,	,
cord-001835-0s7ok4uw	2736	4	electron	electron	NN
cord-001835-0s7ok4uw	2736	5	microscopic	microscopic	JJ
cord-001835-0s7ok4uw	2736	6	analysis	analysis	NN
cord-001835-0s7ok4uw	2736	7	of	of	IN
cord-001835-0s7ok4uw	2736	8	the	the	DT
cord-001835-0s7ok4uw	2736	9	assembly	assembly	NN
cord-001835-0s7ok4uw	2736	10	mixture	mixture	NN
cord-001835-0s7ok4uw	2736	11	showed	show	VBD
cord-001835-0s7ok4uw	2736	12	that	that	IN
cord-001835-0s7ok4uw	2736	13	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2736	14	inhibited	inhibit	VBN
cord-001835-0s7ok4uw	2736	15	microtubule	microtubule	JJ
cord-001835-0s7ok4uw	2736	16	formation	formation	NN
cord-001835-0s7ok4uw	2736	17	in	in	IN
cord-001835-0s7ok4uw	2736	18	vitro	vitro	FW
cord-001835-0s7ok4uw	2736	19	.	.	.
cord-001835-0s7ok4uw	2737	1	The	the	DT
cord-001835-0s7ok4uw	2737	2	binding	binding	NN
cord-001835-0s7ok4uw	2737	3	of	of	IN
cord-001835-0s7ok4uw	2737	4	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2737	5	to	to	IN
cord-001835-0s7ok4uw	2737	6	purified	purify	VBN
cord-001835-0s7ok4uw	2737	7	tubulin	tubulin	NN
cord-001835-0s7ok4uw	2737	8	was	be	VBD
cord-001835-0s7ok4uw	2737	9	monitored	monitor	VBN
cord-001835-0s7ok4uw	2737	10	by	by	IN
cord-001835-0s7ok4uw	2737	11	several	several	JJ
cord-001835-0s7ok4uw	2737	12	complimentary	complimentary	JJ
cord-001835-0s7ok4uw	2737	13	techniques	technique	NNS
cord-001835-0s7ok4uw	2737	14	.	.	.
cord-001835-0s7ok4uw	2738	1	Using	use	VBG
cord-001835-0s7ok4uw	2738	2	size	size	NN
cord-001835-0s7ok4uw	2738	3	exclusion	exclusion	NN
cord-001835-0s7ok4uw	2738	4	chromatography	chromatography	NN
cord-001835-0s7ok4uw	2738	5	,	,	,
cord-001835-0s7ok4uw	2738	6	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2738	7	was	be	VBD
cord-001835-0s7ok4uw	2738	8	found	find	VBN
cord-001835-0s7ok4uw	2738	9	to	to	TO
cord-001835-0s7ok4uw	2738	10	be	be	VB
cord-001835-0s7ok4uw	2738	11	co	co	VBN
cord-001835-0s7ok4uw	2738	12	-	-	VBN
cord-001835-0s7ok4uw	2738	13	eluted	elute	VBN
cord-001835-0s7ok4uw	2738	14	with	with	IN
cord-001835-0s7ok4uw	2738	15	tubulin	tubulin	NN
cord-001835-0s7ok4uw	2738	16	indicating	indicate	VBG
cord-001835-0s7ok4uw	2738	17	that	that	IN
cord-001835-0s7ok4uw	2738	18	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2738	19	binds	bind	VBZ
cord-001835-0s7ok4uw	2738	20	to	to	IN
cord-001835-0s7ok4uw	2738	21	tubulin	tubulin	NN
cord-001835-0s7ok4uw	2738	22	.	.	.
cord-001835-0s7ok4uw	2739	1	Further	further	RB
cord-001835-0s7ok4uw	2739	2	,	,	,
cord-001835-0s7ok4uw	2739	3	the	the	DT
cord-001835-0s7ok4uw	2739	4	interaction	interaction	NN
cord-001835-0s7ok4uw	2739	5	between	between	IN
cord-001835-0s7ok4uw	2739	6	FOR20	for20	NN
cord-001835-0s7ok4uw	2739	7	and	and	CC
cord-001835-0s7ok4uw	2739	8	tubulin	tubulin	NN
cord-001835-0s7ok4uw	2739	9	was	be	VBD
cord-001835-0s7ok4uw	2739	10	analyzed	analyze	VBN
cord-001835-0s7ok4uw	2739	11	by	by	IN
cord-001835-0s7ok4uw	2739	12	surface	surface	NN
cord-001835-0s7ok4uw	2739	13	plasma	plasma	NN
cord-001835-0s7ok4uw	2739	14	resonance	resonance	NN
cord-001835-0s7ok4uw	2739	15	technique	technique	NN
cord-001835-0s7ok4uw	2739	16	and	and	CC
cord-001835-0s7ok4uw	2739	17	the	the	DT
cord-001835-0s7ok4uw	2739	18	result	result	NN
cord-001835-0s7ok4uw	2739	19	showed	show	VBD
cord-001835-0s7ok4uw	2739	20	that	that	IN
cord-001835-0s7ok4uw	2739	21	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2739	22	binds	bind	VBZ
cord-001835-0s7ok4uw	2739	23	to	to	IN
cord-001835-0s7ok4uw	2739	24	tubulin	tubulin	NN
cord-001835-0s7ok4uw	2739	25	with	with	IN
cord-001835-0s7ok4uw	2739	26	a	a	DT
cord-001835-0s7ok4uw	2739	27	modest	modest	JJ
cord-001835-0s7ok4uw	2739	28	affinity	affinity	NN
cord-001835-0s7ok4uw	2739	29	.	.	.
cord-001835-0s7ok4uw	2740	1	The	the	DT
cord-001835-0s7ok4uw	2740	2	data	datum	NNS
cord-001835-0s7ok4uw	2740	3	together	together	RB
cord-001835-0s7ok4uw	2740	4	suggested	suggest	VBD
cord-001835-0s7ok4uw	2740	5	that	that	IN
cord-001835-0s7ok4uw	2740	6	FOR20	FOR20	NNP
cord-001835-0s7ok4uw	2740	7	regulates	regulate	VBZ
cord-001835-0s7ok4uw	2740	8	microtubule	microtubule	NN
cord-001835-0s7ok4uw	2740	9	assembly	assembly	NN
cord-001835-0s7ok4uw	2740	10	through	through	IN
cord-001835-0s7ok4uw	2740	11	a	a	DT
cord-001835-0s7ok4uw	2740	12	direct	direct	JJ
cord-001835-0s7ok4uw	2740	13	interaction	interaction	NN
cord-001835-0s7ok4uw	2740	14	with	with	IN
cord-001835-0s7ok4uw	2740	15	tubulin	tubulin	NN
cord-001835-0s7ok4uw	2740	16	.	.	.
cord-001835-0s7ok4uw	2740	17	 	 	_SP
cord-001835-0s7ok4uw	2741	1	Amide	amide	RB
cord-001835-0s7ok4uw	2741	2	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2741	3	exchange	exchange	NN
cord-001835-0s7ok4uw	2741	4	(	(	-LRB-
cord-001835-0s7ok4uw	2741	5	HX	HX	NNP
cord-001835-0s7ok4uw	2741	6	)	)	-RRB-
cord-001835-0s7ok4uw	2741	7	is	be	VBZ
cord-001835-0s7ok4uw	2741	8	widely	widely	RB
cord-001835-0s7ok4uw	2741	9	used	use	VBN
cord-001835-0s7ok4uw	2741	10	in	in	IN
cord-001835-0s7ok4uw	2741	11	protein	protein	NN
cord-001835-0s7ok4uw	2741	12	biophysics	biophysic	NNS
cord-001835-0s7ok4uw	2741	13	even	even	RB
cord-001835-0s7ok4uw	2741	14	though	though	IN
cord-001835-0s7ok4uw	2741	15	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2741	16	ignorance	ignorance	NN
cord-001835-0s7ok4uw	2741	17	about	about	IN
cord-001835-0s7ok4uw	2741	18	the	the	DT
cord-001835-0s7ok4uw	2741	19	HX	hx	NN
cord-001835-0s7ok4uw	2741	20	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2741	21	makes	make	VBZ
cord-001835-0s7ok4uw	2741	22	data	data	NN
cord-001835-0s7ok4uw	2741	23	interpretation	interpretation	NN
cord-001835-0s7ok4uw	2741	24	imprecise	imprecise	JJ
cord-001835-0s7ok4uw	2741	25	.	.	.
cord-001835-0s7ok4uw	2742	1	Notably	notably	RB
cord-001835-0s7ok4uw	2742	2	,	,	,
cord-001835-0s7ok4uw	2742	3	the	the	DT
cord-001835-0s7ok4uw	2742	4	open	open	JJ
cord-001835-0s7ok4uw	2742	5	exchange	exchange	NN
cord-001835-0s7ok4uw	2742	6	-	-	HYPH
cord-001835-0s7ok4uw	2742	7	competent	competent	JJ
cord-001835-0s7ok4uw	2742	8	conformational	conformational	JJ
cord-001835-0s7ok4uw	2742	9	state	state	NN
cord-001835-0s7ok4uw	2742	10	has	have	VBZ
cord-001835-0s7ok4uw	2742	11	not	not	RB
cord-001835-0s7ok4uw	2742	12	been	be	VBN
cord-001835-0s7ok4uw	2742	13	identified	identify	VBN
cord-001835-0s7ok4uw	2742	14	.	.	.
cord-001835-0s7ok4uw	2743	1	Based	base	VBN
cord-001835-0s7ok4uw	2743	2	on	on	IN
cord-001835-0s7ok4uw	2743	3	analysis	analysis	NN
cord-001835-0s7ok4uw	2743	4	of	of	IN
cord-001835-0s7ok4uw	2743	5	an	an	DT
cord-001835-0s7ok4uw	2743	6	ultra	ultra	JJ
cord-001835-0s7ok4uw	2743	7	-	-	JJ
cord-001835-0s7ok4uw	2743	8	long	long	JJ
cord-001835-0s7ok4uw	2743	9	molecular	molecular	JJ
cord-001835-0s7ok4uw	2743	10	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2743	11	trajectory	trajectory	NN
cord-001835-0s7ok4uw	2743	12	of	of	IN
cord-001835-0s7ok4uw	2743	13	the	the	DT
cord-001835-0s7ok4uw	2743	14	protein	protein	NN
cord-001835-0s7ok4uw	2743	15	BPTI	BPTI	NNP
cord-001835-0s7ok4uw	2743	16	,	,	,
cord-001835-0s7ok4uw	2743	17	we	-PRON-	PRP
cord-001835-0s7ok4uw	2743	18	propose	propose	VBP
cord-001835-0s7ok4uw	2743	19	that	that	IN
cord-001835-0s7ok4uw	2743	20	the	the	DT
cord-001835-0s7ok4uw	2743	21	open	open	JJ
cord-001835-0s7ok4uw	2743	22	(	(	-LRB-
cord-001835-0s7ok4uw	2743	23	O	o	UH
cord-001835-0s7ok4uw	2743	24	)	)	-RRB-
cord-001835-0s7ok4uw	2743	25	states	state	NNS
cord-001835-0s7ok4uw	2743	26	for	for	IN
cord-001835-0s7ok4uw	2743	27	amides	amide	NNS
cord-001835-0s7ok4uw	2743	28	that	that	WDT
cord-001835-0s7ok4uw	2743	29	exchange	exchange	VBP
cord-001835-0s7ok4uw	2743	30	by	by	IN
cord-001835-0s7ok4uw	2743	31	subglobal	subglobal	JJ
cord-001835-0s7ok4uw	2743	32	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	2743	33	are	be	VBP
cord-001835-0s7ok4uw	2743	34	locally	locally	RB
cord-001835-0s7ok4uw	2743	35	distorted	distort	VBN
cord-001835-0s7ok4uw	2743	36	conformations	conformation	NNS
cord-001835-0s7ok4uw	2743	37	with	with	IN
cord-001835-0s7ok4uw	2743	38	two	two	CD
cord-001835-0s7ok4uw	2743	39	water	water	NN
cord-001835-0s7ok4uw	2743	40	molecules	molecule	NNS
cord-001835-0s7ok4uw	2743	41	directly	directly	RB
cord-001835-0s7ok4uw	2743	42	coordinated	coordinate	VBN
cord-001835-0s7ok4uw	2743	43	to	to	IN
cord-001835-0s7ok4uw	2743	44	the	the	DT
cord-001835-0s7ok4uw	2743	45	N	N	NNP
cord-001835-0s7ok4uw	2743	46	-	-	HYPH
cord-001835-0s7ok4uw	2743	47	H	H	NNP
cord-001835-0s7ok4uw	2743	48	group	group	NN
cord-001835-0s7ok4uw	2743	49	.	.	.
cord-001835-0s7ok4uw	2744	1	The	the	DT
cord-001835-0s7ok4uw	2744	2	HX	HX	NNP
cord-001835-0s7ok4uw	2744	3	protection	protection	NN
cord-001835-0s7ok4uw	2744	4	factors	factor	NNS
cord-001835-0s7ok4uw	2744	5	computed	compute	VBN
cord-001835-0s7ok4uw	2744	6	from	from	IN
cord-001835-0s7ok4uw	2744	7	the	the	DT
cord-001835-0s7ok4uw	2744	8	relative	relative	JJ
cord-001835-0s7ok4uw	2744	9	O	o	NN
cord-001835-0s7ok4uw	2744	10	-	-	HYPH
cord-001835-0s7ok4uw	2744	11	state	state	NN
cord-001835-0s7ok4uw	2744	12	populations	population	NNS
cord-001835-0s7ok4uw	2744	13	agree	agree	VBP
cord-001835-0s7ok4uw	2744	14	well	well	RB
cord-001835-0s7ok4uw	2744	15	with	with	IN
cord-001835-0s7ok4uw	2744	16	experiment	experiment	NN
cord-001835-0s7ok4uw	2744	17	.	.	.
cord-001835-0s7ok4uw	2745	1	The	the	DT
cord-001835-0s7ok4uw	2745	2	O	O	NNP
cord-001835-0s7ok4uw	2745	3	states	state	NNS
cord-001835-0s7ok4uw	2745	4	of	of	IN
cord-001835-0s7ok4uw	2745	5	different	different	JJ
cord-001835-0s7ok4uw	2745	6	amides	amide	NNS
cord-001835-0s7ok4uw	2745	7	show	show	VBP
cord-001835-0s7ok4uw	2745	8	little	little	JJ
cord-001835-0s7ok4uw	2745	9	or	or	CC
cord-001835-0s7ok4uw	2745	10	no	no	DT
cord-001835-0s7ok4uw	2745	11	temporal	temporal	JJ
cord-001835-0s7ok4uw	2745	12	correlation	correlation	NN
cord-001835-0s7ok4uw	2745	13	,	,	,
cord-001835-0s7ok4uw	2745	14	even	even	RB
cord-001835-0s7ok4uw	2745	15	if	if	IN
cord-001835-0s7ok4uw	2745	16	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	2745	17	residues	residue	NNS
cord-001835-0s7ok4uw	2745	18	unfold	unfold	VBP
cord-001835-0s7ok4uw	2745	19	cooperatively	cooperatively	RB
cord-001835-0s7ok4uw	2745	20	.	.	.
cord-001835-0s7ok4uw	2746	1	The	the	DT
cord-001835-0s7ok4uw	2746	2	mean	mean	JJ
cord-001835-0s7ok4uw	2746	3	residence	residence	NN
cord-001835-0s7ok4uw	2746	4	time	time	NN
cord-001835-0s7ok4uw	2746	5	of	of	IN
cord-001835-0s7ok4uw	2746	6	the	the	DT
cord-001835-0s7ok4uw	2746	7	O	o	NN
cord-001835-0s7ok4uw	2746	8	state	state	NN
cord-001835-0s7ok4uw	2746	9	is	be	VBZ
cord-001835-0s7ok4uw	2746	10	100	100	CD
cord-001835-0s7ok4uw	2746	11	ps	ps	NN
cord-001835-0s7ok4uw	2746	12	for	for	IN
cord-001835-0s7ok4uw	2746	13	all	all	DT
cord-001835-0s7ok4uw	2746	14	examined	examine	VBN
cord-001835-0s7ok4uw	2746	15	amides	amide	NNS
cord-001835-0s7ok4uw	2746	16	,	,	,
cord-001835-0s7ok4uw	2746	17	so	so	IN
cord-001835-0s7ok4uw	2746	18	the	the	DT
cord-001835-0s7ok4uw	2746	19	large	large	JJ
cord-001835-0s7ok4uw	2746	20	variation	variation	NN
cord-001835-0s7ok4uw	2746	21	in	in	IN
cord-001835-0s7ok4uw	2746	22	measured	measure	VBN
cord-001835-0s7ok4uw	2746	23	HX	hx	NN
cord-001835-0s7ok4uw	2746	24	rate	rate	NN
cord-001835-0s7ok4uw	2746	25	must	must	MD
cord-001835-0s7ok4uw	2746	26	be	be	VB
cord-001835-0s7ok4uw	2746	27	attributed	attribute	VBN
cord-001835-0s7ok4uw	2746	28	to	to	IN
cord-001835-0s7ok4uw	2746	29	the	the	DT
cord-001835-0s7ok4uw	2746	30	opening	opening	NN
cord-001835-0s7ok4uw	2746	31	frequency	frequency	NN
cord-001835-0s7ok4uw	2746	32	.	.	.
cord-001835-0s7ok4uw	2747	1	A	a	DT
cord-001835-0s7ok4uw	2747	2	few	few	JJ
cord-001835-0s7ok4uw	2747	3	amides	amide	NNS
cord-001835-0s7ok4uw	2747	4	gain	gain	VBP
cord-001835-0s7ok4uw	2747	5	solvent	solvent	NN
cord-001835-0s7ok4uw	2747	6	access	access	NN
cord-001835-0s7ok4uw	2747	7	via	via	IN
cord-001835-0s7ok4uw	2747	8	tunnels	tunnel	NNS
cord-001835-0s7ok4uw	2747	9	or	or	CC
cord-001835-0s7ok4uw	2747	10	pores	pore	NNS
cord-001835-0s7ok4uw	2747	11	penetrated	penetrate	VBN
cord-001835-0s7ok4uw	2747	12	by	by	IN
cord-001835-0s7ok4uw	2747	13	water	water	NN
cord-001835-0s7ok4uw	2747	14	chains	chain	NNS
cord-001835-0s7ok4uw	2747	15	including	include	VBG
cord-001835-0s7ok4uw	2747	16	native	native	JJ
cord-001835-0s7ok4uw	2747	17	internal	internal	JJ
cord-001835-0s7ok4uw	2747	18	water	water	NN
cord-001835-0s7ok4uw	2747	19	molecules	molecule	NNS
cord-001835-0s7ok4uw	2747	20	,	,	,
cord-001835-0s7ok4uw	2747	21	but	but	CC
cord-001835-0s7ok4uw	2747	22	most	most	JJS
cord-001835-0s7ok4uw	2747	23	amides	amide	NNS
cord-001835-0s7ok4uw	2747	24	access	access	VBP
cord-001835-0s7ok4uw	2747	25	solvent	solvent	NN
cord-001835-0s7ok4uw	2747	26	by	by	IN
cord-001835-0s7ok4uw	2747	27	more	more	JJR
cord-001835-0s7ok4uw	2747	28	local	local	JJ
cord-001835-0s7ok4uw	2747	29	structural	structural	JJ
cord-001835-0s7ok4uw	2747	30	distortions	distortion	NNS
cord-001835-0s7ok4uw	2747	31	.	.	.
cord-001835-0s7ok4uw	2748	1	In	in	IN
cord-001835-0s7ok4uw	2748	2	either	either	DT
cord-001835-0s7ok4uw	2748	3	case	case	NN
cord-001835-0s7ok4uw	2748	4	,	,	,
cord-001835-0s7ok4uw	2748	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2748	6	argue	argue	VBP
cord-001835-0s7ok4uw	2748	7	that	that	IN
cord-001835-0s7ok4uw	2748	8	an	an	DT
cord-001835-0s7ok4uw	2748	9	over	over	RB
cord-001835-0s7ok4uw	2748	10	-	-	HYPH
cord-001835-0s7ok4uw	2748	11	coordinated	coordinated	JJ
cord-001835-0s7ok4uw	2748	12	N	N	NNP
cord-001835-0s7ok4uw	2748	13	-	-	HYPH
cord-001835-0s7ok4uw	2748	14	H	H	NNP
cord-001835-0s7ok4uw	2748	15	group	group	NN
cord-001835-0s7ok4uw	2748	16	is	be	VBZ
cord-001835-0s7ok4uw	2748	17	necessary	necessary	JJ
cord-001835-0s7ok4uw	2748	18	for	for	IN
cord-001835-0s7ok4uw	2748	19	efficient	efficient	JJ
cord-001835-0s7ok4uw	2748	20	proton	proton	NN
cord-001835-0s7ok4uw	2748	21	transfer	transfer	NN
cord-001835-0s7ok4uw	2748	22	by	by	IN
cord-001835-0s7ok4uw	2748	23	Grotthuss	Grotthuss	NNP
cord-001835-0s7ok4uw	2748	24	-	-	HYPH
cord-001835-0s7ok4uw	2748	25	type	type	NN
cord-001835-0s7ok4uw	2748	26	structural	structural	JJ
cord-001835-0s7ok4uw	2748	27	diffusion	diffusion	NN
cord-001835-0s7ok4uw	2748	28	.	.	.
cord-001835-0s7ok4uw	2749	1	Differences	difference	NNS
cord-001835-0s7ok4uw	2749	2	in	in	IN
cord-001835-0s7ok4uw	2749	3	redox	redox	JJ
cord-001835-0s7ok4uw	2749	4	reactions	reaction	NNS
cord-001835-0s7ok4uw	2749	5	with	with	IN
cord-001835-0s7ok4uw	2749	6	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	2749	7	/	/	SYM
cord-001835-0s7ok4uw	2749	8	H	h	NN
cord-001835-0s7ok4uw	2749	9	between	between	IN
cord-001835-0s7ok4uw	2749	10	ferredoxin	ferredoxin	JJ
cord-001835-0s7ok4uw	2749	11	-	-	HYPH
cord-001835-0s7ok4uw	2749	12	NADP1	nadp1	JJ
cord-001835-0s7ok4uw	2749	13	oxidoreductases	oxidoreductase	NNS
cord-001835-0s7ok4uw	2749	14	from	from	IN
cord-001835-0s7ok4uw	2749	15	Bacillus	bacillus	NN
cord-001835-0s7ok4uw	2749	16	subtilis	subtili	NNS
cord-001835-0s7ok4uw	2749	17	and	and	CC
cord-001835-0s7ok4uw	2749	18	Rhodopseudomonas	Rhodopseudomonas	NNP
cord-001835-0s7ok4uw	2749	19	palustris	palustris	NN
cord-001835-0s7ok4uw	2749	20	Daisuke	Daisuke	NNP
cord-001835-0s7ok4uw	2749	21	Seo	Seo	NNP
cord-001835-0s7ok4uw	2749	22	1	1	CD
cord-001835-0s7ok4uw	2749	23	,	,	,
cord-001835-0s7ok4uw	2749	24	Hidehiro	Hidehiro	NNP
cord-001835-0s7ok4uw	2749	25	Sakurai	Sakurai	NNP
cord-001835-0s7ok4uw	2749	26	2	2	CD
cord-001835-0s7ok4uw	2749	27	,	,	,
cord-001835-0s7ok4uw	2749	28	Pierre	Pierre	NNP
cord-001835-0s7ok4uw	2749	29	S	S	NNP
cord-001835-0s7ok4uw	2749	30	etif	etif	NN
cord-001835-0s7ok4uw	2749	31	3	3	CD
cord-001835-0s7ok4uw	2749	32	,	,	,
cord-001835-0s7ok4uw	2749	33	Takeshi	Takeshi	NNP
cord-001835-0s7ok4uw	2749	34	Sakurai	Sakurai	NNP
cord-001835-0s7ok4uw	2749	35	1	1	CD
cord-001835-0s7ok4uw	2749	36	1	1	CD
cord-001835-0s7ok4uw	2749	37	Graduate	Graduate	NNP
cord-001835-0s7ok4uw	2749	38	School	School	NNP
cord-001835-0s7ok4uw	2749	39	of	of	IN
cord-001835-0s7ok4uw	2749	40	Natural	Natural	NNP
cord-001835-0s7ok4uw	2749	41	Science	Science	NNP
cord-001835-0s7ok4uw	2749	42	and	and	CC
cord-001835-0s7ok4uw	2749	43	Technology	Technology	NNP
cord-001835-0s7ok4uw	2749	44	,	,	,
cord-001835-0s7ok4uw	2750	1	Kanazawa	Kanazawa	NNP
cord-001835-0s7ok4uw	2750	2	Univ	Univ	NNP
cord-001835-0s7ok4uw	2750	3	.	.	.
cord-001835-0s7ok4uw	2751	1	,	,	,
cord-001835-0s7ok4uw	2751	2	2	2	CD
cord-001835-0s7ok4uw	2751	3	Research	Research	NNP
cord-001835-0s7ok4uw	2751	4	Institute	Institute	NNP
cord-001835-0s7ok4uw	2751	5	for	for	IN
cord-001835-0s7ok4uw	2751	6	Photobiological	Photobiological	NNP
cord-001835-0s7ok4uw	2751	7	Hydrogen	Hydrogen	NNP
cord-001835-0s7ok4uw	2751	8	Production	Production	NNP
cord-001835-0s7ok4uw	2751	9	,	,	,
cord-001835-0s7ok4uw	2751	10	Kanagawa	Kanagawa	NNP
cord-001835-0s7ok4uw	2751	11	University	University	NNP
cord-001835-0s7ok4uw	2751	12	,	,	,
cord-001835-0s7ok4uw	2751	13	3	3	CD
cord-001835-0s7ok4uw	2751	14	 	 	_SP
cord-001835-0s7ok4uw	2751	15	Ferredoxin	Ferredoxin	NNP
cord-001835-0s7ok4uw	2751	16	-	-	HYPH
cord-001835-0s7ok4uw	2751	17	NAD(P)1	NAD(P)1	NNP
cord-001835-0s7ok4uw	2751	18	oxidoreductase	oxidoreductase	NN
cord-001835-0s7ok4uw	2751	19	(	(	-LRB-
cord-001835-0s7ok4uw	2751	20	FNR	FNR	NNP
cord-001835-0s7ok4uw	2751	21	)	)	-RRB-
cord-001835-0s7ok4uw	2751	22	is	be	VBZ
cord-001835-0s7ok4uw	2751	23	a	a	DT
cord-001835-0s7ok4uw	2751	24	ubiquitous	ubiquitous	JJ
cord-001835-0s7ok4uw	2751	25	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2751	26	that	that	WDT
cord-001835-0s7ok4uw	2751	27	catalyze	catalyze	VBP
cord-001835-0s7ok4uw	2751	28	the	the	DT
cord-001835-0s7ok4uw	2751	29	redox	redox	JJ
cord-001835-0s7ok4uw	2751	30	reaction	reaction	NN
cord-001835-0s7ok4uw	2751	31	between	between	IN
cord-001835-0s7ok4uw	2751	32	soluble	soluble	JJ
cord-001835-0s7ok4uw	2751	33	small	small	JJ
cord-001835-0s7ok4uw	2751	34	iron	iron	NN
cord-001835-0s7ok4uw	2751	35	-	-	HYPH
cord-001835-0s7ok4uw	2751	36	sulfur	sulfur	NN
cord-001835-0s7ok4uw	2751	37	protein	protein	NN
cord-001835-0s7ok4uw	2751	38	ferredoxin	ferredoxin	NN
cord-001835-0s7ok4uw	2751	39	and	and	CC
cord-001835-0s7ok4uw	2751	40	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	2751	41	/	/	SYM
cord-001835-0s7ok4uw	2751	42	H.	H.	NNP
cord-001835-0s7ok4uw	2751	43	FNRs	fnrs	NN
cord-001835-0s7ok4uw	2751	44	from	from	IN
cord-001835-0s7ok4uw	2751	45	photosynthetic	photosynthetic	JJ
cord-001835-0s7ok4uw	2751	46	green	green	JJ
cord-001835-0s7ok4uw	2751	47	sulfur	sulfur	NN
cord-001835-0s7ok4uw	2751	48	bacterium	bacterium	NN
cord-001835-0s7ok4uw	2751	49	Chlorobaculum	Chlorobaculum	NNP
cord-001835-0s7ok4uw	2751	50	tepidum	tepidum	NNP
cord-001835-0s7ok4uw	2752	1	(	(	-LRB-
cord-001835-0s7ok4uw	2752	2	CtFNR	CtFNR	NNP
cord-001835-0s7ok4uw	2752	3	)	)	-RRB-
cord-001835-0s7ok4uw	2752	4	,	,	,
cord-001835-0s7ok4uw	2752	5	low	low	JJ
cord-001835-0s7ok4uw	2752	6	-	-	HYPH
cord-001835-0s7ok4uw	2752	7	GC	gc	NN
cord-001835-0s7ok4uw	2752	8	content	content	NN
cord-001835-0s7ok4uw	2752	9	gram	gram	NN
cord-001835-0s7ok4uw	2752	10	-	-	HYPH
cord-001835-0s7ok4uw	2752	11	positive	positive	JJ
cord-001835-0s7ok4uw	2752	12	bacterium	bacterium	NN
cord-001835-0s7ok4uw	2752	13	Bacillus	bacillus	NN
cord-001835-0s7ok4uw	2752	14	subtilis	subtili	NNS
cord-001835-0s7ok4uw	2752	15	(	(	-LRB-
cord-001835-0s7ok4uw	2752	16	BsFNR	bsfnr	NN
cord-001835-0s7ok4uw	2752	17	)	)	-RRB-
cord-001835-0s7ok4uw	2752	18	and	and	CC
cord-001835-0s7ok4uw	2752	19	purple	purple	JJ
cord-001835-0s7ok4uw	2752	20	non	non	JJ
cord-001835-0s7ok4uw	2752	21	-	-	JJ
cord-001835-0s7ok4uw	2752	22	sulfur	sulfur	JJ
cord-001835-0s7ok4uw	2752	23	bacterium	bacterium	NN
cord-001835-0s7ok4uw	2753	1	Rhodopseudomonas	Rhodopseudomonas	NNP
cord-001835-0s7ok4uw	2753	2	palustris	palustris	NN
cord-001835-0s7ok4uw	2753	3	(	(	-LRB-
cord-001835-0s7ok4uw	2754	1	RpFNR	rpfnr	NN
cord-001835-0s7ok4uw	2754	2	)	)	-RRB-
cord-001835-0s7ok4uw	2754	3	are	be	VBP
cord-001835-0s7ok4uw	2754	4	homodimeric	homodimeric	NNP
cord-001835-0s7ok4uw	2754	5	proteins	protein	NNS
cord-001835-0s7ok4uw	2754	6	containing	contain	VBG
cord-001835-0s7ok4uw	2754	7	one	one	CD
cord-001835-0s7ok4uw	2754	8	FAD	fad	NN
cord-001835-0s7ok4uw	2754	9	prosthetic	prosthetic	JJ
cord-001835-0s7ok4uw	2754	10	group	group	NN
cord-001835-0s7ok4uw	2754	11	per	per	IN
cord-001835-0s7ok4uw	2754	12	subunit	subunit	NN
cord-001835-0s7ok4uw	2754	13	.	.	.
cord-001835-0s7ok4uw	2755	1	Crystal	crystal	NN
cord-001835-0s7ok4uw	2755	2	structure	structure	NN
cord-001835-0s7ok4uw	2755	3	analyses	analysis	NNS
cord-001835-0s7ok4uw	2755	4	of	of	IN
cord-001835-0s7ok4uw	2755	5	Ct	Ct	NNP
cord-001835-0s7ok4uw	2755	6	-	-	,
cord-001835-0s7ok4uw	2755	7	and	and	CC
cord-001835-0s7ok4uw	2755	8	BsFNRs	BsFNRs	NNP
cord-001835-0s7ok4uw	2755	9	have	have	VBP
cord-001835-0s7ok4uw	2755	10	revealed	reveal	VBN
cord-001835-0s7ok4uw	2755	11	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2755	12	significant	significant	JJ
cord-001835-0s7ok4uw	2755	13	structural	structural	JJ
cord-001835-0s7ok4uw	2755	14	homology	homology	NN
cord-001835-0s7ok4uw	2755	15	to	to	IN
cord-001835-0s7ok4uw	2755	16	NADPH	nadph	NN
cord-001835-0s7ok4uw	2755	17	-	-	HYPH
cord-001835-0s7ok4uw	2755	18	thioredoxin	thioredoxin	JJ
cord-001835-0s7ok4uw	2755	19	reductase	reductase	NN
cord-001835-0s7ok4uw	2755	20	from	from	IN
cord-001835-0s7ok4uw	2755	21	Eschelicia	Eschelicia	NNP
cord-001835-0s7ok4uw	2755	22	coli	coli	NNS
cord-001835-0s7ok4uw	2755	23	,	,	,
cord-001835-0s7ok4uw	2755	24	which	which	WDT
cord-001835-0s7ok4uw	2755	25	is	be	VBZ
cord-001835-0s7ok4uw	2755	26	distinct	distinct	JJ
cord-001835-0s7ok4uw	2755	27	from	from	IN
cord-001835-0s7ok4uw	2755	28	the	the	DT
cord-001835-0s7ok4uw	2755	29	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	2755	30	FNRs	fnr	NNS
cord-001835-0s7ok4uw	2755	31	from	from	IN
cord-001835-0s7ok4uw	2755	32	plastids	plastid	NNS
cord-001835-0s7ok4uw	2755	33	of	of	IN
cord-001835-0s7ok4uw	2755	34	higher	high	JJR
cord-001835-0s7ok4uw	2755	35	plants	plant	NNS
cord-001835-0s7ok4uw	2755	36	,	,	,
cord-001835-0s7ok4uw	2755	37	cyanobacteria	cyanobacteria	NNS
cord-001835-0s7ok4uw	2755	38	,	,	,
cord-001835-0s7ok4uw	2755	39	g	g	NN
cord-001835-0s7ok4uw	2755	40	-	-	HYPH
cord-001835-0s7ok4uw	2755	41	proteobacteria	proteobacteria	NNS
cord-001835-0s7ok4uw	2755	42	and	and	CC
cord-001835-0s7ok4uw	2755	43	putidaredoxin	putidaredoxin	JJ
cord-001835-0s7ok4uw	2755	44	reductase	reductase	NN
cord-001835-0s7ok4uw	2755	45	.	.	.
cord-001835-0s7ok4uw	2756	1	Previous	previous	JJ
cord-001835-0s7ok4uw	2756	2	studies	study	NNS
cord-001835-0s7ok4uw	2756	3	on	on	IN
cord-001835-0s7ok4uw	2756	4	steady	steady	JJ
cord-001835-0s7ok4uw	2756	5	-	-	HYPH
cord-001835-0s7ok4uw	2756	6	state	state	NN
cord-001835-0s7ok4uw	2756	7	reaction	reaction	NN
cord-001835-0s7ok4uw	2756	8	of	of	IN
cord-001835-0s7ok4uw	2756	9	Bs	Bs	NNP
cord-001835-0s7ok4uw	2756	10	-	-	,
cord-001835-0s7ok4uw	2756	11	and	and	CC
cord-001835-0s7ok4uw	2756	12	RpFNRs	RpFNRs	NNP
cord-001835-0s7ok4uw	2756	13	with	with	IN
cord-001835-0s7ok4uw	2756	14	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	2756	15	/	/	SYM
cord-001835-0s7ok4uw	2756	16	H	H	NNP
cord-001835-0s7ok4uw	2756	17	by	by	IN
cord-001835-0s7ok4uw	2756	18	diaphorase	diaphorase	NN
cord-001835-0s7ok4uw	2756	19	assay	assay	NN
cord-001835-0s7ok4uw	2756	20	have	have	VBP
cord-001835-0s7ok4uw	2756	21	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	2756	22	that	that	IN
cord-001835-0s7ok4uw	2756	23	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2756	24	oxidation	oxidation	NN
cord-001835-0s7ok4uw	2756	25	rates	rate	NNS
cord-001835-0s7ok4uw	2756	26	of	of	IN
cord-001835-0s7ok4uw	2756	27	BsFNR	BsFNR	NNP
cord-001835-0s7ok4uw	2757	1	and	and	CC
cord-001835-0s7ok4uw	2757	2	RpFNR	RpFNR	NNP
cord-001835-0s7ok4uw	2757	3	were	be	VBD
cord-001835-0s7ok4uw	2757	4	comparable	comparable	JJ
cord-001835-0s7ok4uw	2757	5	to	to	IN
cord-001835-0s7ok4uw	2757	6	those	those	DT
cord-001835-0s7ok4uw	2757	7	of	of	IN
cord-001835-0s7ok4uw	2757	8	the	the	DT
cord-001835-0s7ok4uw	2757	9	FNRs	fnr	NNS
cord-001835-0s7ok4uw	2757	10	from	from	IN
cord-001835-0s7ok4uw	2757	11	plastid	plastid	NN
cord-001835-0s7ok4uw	2757	12	and	and	CC
cord-001835-0s7ok4uw	2757	13	cyanobacteria	cyanobacteria	NNS
cord-001835-0s7ok4uw	2757	14	.	.	.
cord-001835-0s7ok4uw	2758	1	But	but	CC
cord-001835-0s7ok4uw	2758	2	affinities	affinity	NNS
cord-001835-0s7ok4uw	2758	3	toward	toward	IN
cord-001835-0s7ok4uw	2758	4	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	2758	5	/	/	SYM
cord-001835-0s7ok4uw	2758	6	H	h	NN
cord-001835-0s7ok4uw	2758	7	and	and	CC
cord-001835-0s7ok4uw	2758	8	rates	rate	NNS
cord-001835-0s7ok4uw	2758	9	for	for	IN
cord-001835-0s7ok4uw	2758	10	oxidation	oxidation	NN
cord-001835-0s7ok4uw	2758	11	of	of	IN
cord-001835-0s7ok4uw	2758	12	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2758	13	differed	differ	VBD
cord-001835-0s7ok4uw	2758	14	significantly	significantly	RB
cord-001835-0s7ok4uw	2758	15	between	between	IN
cord-001835-0s7ok4uw	2758	16	BsFNR	BsFNR	NNP
cord-001835-0s7ok4uw	2759	1	and	and	CC
cord-001835-0s7ok4uw	2759	2	RpFNR	RpFNR	NNP
cord-001835-0s7ok4uw	2759	3	,	,	,
cord-001835-0s7ok4uw	2759	4	despite	despite	IN
cord-001835-0s7ok4uw	2759	5	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2759	6	high	high	JJ
cord-001835-0s7ok4uw	2759	7	amino	amino	NN
cord-001835-0s7ok4uw	2759	8	acid	acid	NN
cord-001835-0s7ok4uw	2759	9	sequence	sequence	NN
cord-001835-0s7ok4uw	2759	10	homology	homology	NN
cord-001835-0s7ok4uw	2759	11	.	.	.
cord-001835-0s7ok4uw	2760	1	In	in	IN
cord-001835-0s7ok4uw	2760	2	this	this	DT
cord-001835-0s7ok4uw	2760	3	work	work	NN
cord-001835-0s7ok4uw	2760	4	,	,	,
cord-001835-0s7ok4uw	2760	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2760	6	report	report	VBP
cord-001835-0s7ok4uw	2760	7	pre	pre	JJ
cord-001835-0s7ok4uw	2760	8	-	-	JJ
cord-001835-0s7ok4uw	2760	9	steady	steady	JJ
cord-001835-0s7ok4uw	2760	10	state	state	NN
cord-001835-0s7ok4uw	2760	11	reactions	reaction	NNS
cord-001835-0s7ok4uw	2760	12	of	of	IN
cord-001835-0s7ok4uw	2760	13	BsFNR	BsFNR	NNP
cord-001835-0s7ok4uw	2761	1	and	and	CC
cord-001835-0s7ok4uw	2761	2	RpFNR	RpFNR	NNP
cord-001835-0s7ok4uw	2761	3	with	with	IN
cord-001835-0s7ok4uw	2761	4	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	2761	5	/	/	SYM
cord-001835-0s7ok4uw	2761	6	H	H	NNP
cord-001835-0s7ok4uw	2761	7	by	by	IN
cord-001835-0s7ok4uw	2761	8	a	a	DT
cord-001835-0s7ok4uw	2761	9	stopped	stop	VBN
cord-001835-0s7ok4uw	2761	10	-	-	HYPH
cord-001835-0s7ok4uw	2761	11	flow	flow	NN
cord-001835-0s7ok4uw	2761	12	spectrophotometry	spectrophotometry	NN
cord-001835-0s7ok4uw	2761	13	.	.	.
cord-001835-0s7ok4uw	2762	1	Mixing	mix	VBG
cord-001835-0s7ok4uw	2762	2	oxidized	oxidize	VBN
cord-001835-0s7ok4uw	2762	3	BsFNR	bsfnr	NN
cord-001835-0s7ok4uw	2763	1	with	with	IN
cord-001835-0s7ok4uw	2763	2	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2763	3	yielded	yield	VBD
cord-001835-0s7ok4uw	2763	4	a	a	DT
cord-001835-0s7ok4uw	2763	5	rapid	rapid	JJ
cord-001835-0s7ok4uw	2763	6	formation	formation	NN
cord-001835-0s7ok4uw	2763	7	of	of	IN
cord-001835-0s7ok4uw	2763	8	charge	charge	NN
cord-001835-0s7ok4uw	2763	9	transfer	transfer	NN
cord-001835-0s7ok4uw	2763	10	complexes	complex	NNS
cord-001835-0s7ok4uw	2763	11	(	(	-LRB-
cord-001835-0s7ok4uw	2763	12	CTCs	CTCs	NNP
cord-001835-0s7ok4uw	2763	13	)	)	-RRB-
cord-001835-0s7ok4uw	2763	14	followed	follow	VBN
cord-001835-0s7ok4uw	2763	15	by	by	IN
cord-001835-0s7ok4uw	2763	16	a	a	DT
cord-001835-0s7ok4uw	2763	17	reduction	reduction	NN
cord-001835-0s7ok4uw	2763	18	of	of	IN
cord-001835-0s7ok4uw	2763	19	the	the	DT
cord-001835-0s7ok4uw	2763	20	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2763	21	.	.	.
cord-001835-0s7ok4uw	2764	1	BsFNR	BsFNR	NNP
cord-001835-0s7ok4uw	2764	2	was	be	VBD
cord-001835-0s7ok4uw	2764	3	almost	almost	RB
cord-001835-0s7ok4uw	2764	4	fully	fully	RB
cord-001835-0s7ok4uw	2764	5	reduced	reduce	VBN
cord-001835-0s7ok4uw	2764	6	at	at	IN
cord-001835-0s7ok4uw	2764	7	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	2764	8	.	.	.
cord-001835-0s7ok4uw	2765	1	Mixing	mix	VBG
cord-001835-0s7ok4uw	2765	2	photochemically	photochemically	RB
cord-001835-0s7ok4uw	2765	3	reduced	reduce	VBN
cord-001835-0s7ok4uw	2765	4	BsFNR	BsFNR	NNP
cord-001835-0s7ok4uw	2765	5	with	with	IN
cord-001835-0s7ok4uw	2765	6	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	2765	7	also	also	RB
cord-001835-0s7ok4uw	2765	8	rapidly	rapidly	RB
cord-001835-0s7ok4uw	2765	9	provided	provide	VBD
cord-001835-0s7ok4uw	2765	10	an	an	DT
cord-001835-0s7ok4uw	2765	11	absorption	absorption	NN
cord-001835-0s7ok4uw	2765	12	spectrum	spectrum	NN
cord-001835-0s7ok4uw	2765	13	of	of	IN
cord-001835-0s7ok4uw	2765	14	CTC	CTC	NNP
cord-001835-0s7ok4uw	2765	15	but	but	CC
cord-001835-0s7ok4uw	2765	16	followed	follow	VBD
cord-001835-0s7ok4uw	2765	17	reoxidation	reoxidation	NN
cord-001835-0s7ok4uw	2765	18	of	of	IN
cord-001835-0s7ok4uw	2765	19	reduced	reduce	VBN
cord-001835-0s7ok4uw	2765	20	BsFNR	BsFNR	NNP
cord-001835-0s7ok4uw	2765	21	was	be	VBD
cord-001835-0s7ok4uw	2765	22	very	very	RB
cord-001835-0s7ok4uw	2765	23	slow	slow	JJ
cord-001835-0s7ok4uw	2765	24	.	.	.
cord-001835-0s7ok4uw	2766	1	The	the	DT
cord-001835-0s7ok4uw	2766	2	amount	amount	NN
cord-001835-0s7ok4uw	2766	3	of	of	IN
cord-001835-0s7ok4uw	2766	4	oxidized	oxidize	VBN
cord-001835-0s7ok4uw	2766	5	BsFNR	BsFNR	NNP
cord-001835-0s7ok4uw	2766	6	after	after	IN
cord-001835-0s7ok4uw	2766	7	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	2766	8	depended	depend	VBD
cord-001835-0s7ok4uw	2766	9	on	on	IN
cord-001835-0s7ok4uw	2766	10	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	2766	11	concentration	concentration	NN
cord-001835-0s7ok4uw	2766	12	.	.	.
cord-001835-0s7ok4uw	2767	1	Kinetic	kinetic	JJ
cord-001835-0s7ok4uw	2767	2	analyses	analysis	NNS
cord-001835-0s7ok4uw	2767	3	indicated	indicate	VBD
cord-001835-0s7ok4uw	2767	4	that	that	IN
cord-001835-0s7ok4uw	2767	5	the	the	DT
cord-001835-0s7ok4uw	2767	6	rate	rate	NN
cord-001835-0s7ok4uw	2767	7	-	-	HYPH
cord-001835-0s7ok4uw	2767	8	determining	determine	VBG
cord-001835-0s7ok4uw	2767	9	steps	step	NNS
cord-001835-0s7ok4uw	2767	10	were	be	VBD
cord-001835-0s7ok4uw	2767	11	the	the	DT
cord-001835-0s7ok4uw	2767	12	hydride	hydride	NN
cord-001835-0s7ok4uw	2767	13	-	-	HYPH
cord-001835-0s7ok4uw	2767	14	transfer	transfer	NN
cord-001835-0s7ok4uw	2767	15	reactions	reaction	NNS
cord-001835-0s7ok4uw	2767	16	in	in	IN
cord-001835-0s7ok4uw	2767	17	both	both	DT
cord-001835-0s7ok4uw	2767	18	directions	direction	NNS
cord-001835-0s7ok4uw	2767	19	and	and	CC
cord-001835-0s7ok4uw	2767	20	the	the	DT
cord-001835-0s7ok4uw	2767	21	rate	rate	NN
cord-001835-0s7ok4uw	2767	22	for	for	IN
cord-001835-0s7ok4uw	2767	23	the	the	DT
cord-001835-0s7ok4uw	2767	24	forward	forward	JJ
cord-001835-0s7ok4uw	2767	25	direction	direction	NN
cord-001835-0s7ok4uw	2767	26	was	be	VBD
cord-001835-0s7ok4uw	2767	27	much	much	RB
cord-001835-0s7ok4uw	2767	28	faster	fast	JJR
cord-001835-0s7ok4uw	2767	29	than	than	IN
cord-001835-0s7ok4uw	2767	30	that	that	DT
cord-001835-0s7ok4uw	2767	31	for	for	IN
cord-001835-0s7ok4uw	2767	32	the	the	DT
cord-001835-0s7ok4uw	2767	33	reverse	reverse	JJ
cord-001835-0s7ok4uw	2767	34	direction	direction	NN
cord-001835-0s7ok4uw	2767	35	.	.	.
cord-001835-0s7ok4uw	2768	1	Mixing	mix	VBG
cord-001835-0s7ok4uw	2768	2	oxidized	oxidized	JJ
cord-001835-0s7ok4uw	2768	3	RpFNR	RpFNR	NNP
cord-001835-0s7ok4uw	2768	4	with	with	IN
cord-001835-0s7ok4uw	2768	5	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2768	6	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	2768	7	a	a	DT
cord-001835-0s7ok4uw	2768	8	rapid	rapid	JJ
cord-001835-0s7ok4uw	2768	9	CTCs	ctc	NNS
cord-001835-0s7ok4uw	2768	10	formation	formation	NN
cord-001835-0s7ok4uw	2768	11	followed	follow	VBN
cord-001835-0s7ok4uw	2768	12	by	by	IN
cord-001835-0s7ok4uw	2768	13	a	a	DT
cord-001835-0s7ok4uw	2768	14	slower	slow	JJR
cord-001835-0s7ok4uw	2768	15	reduction	reduction	NN
cord-001835-0s7ok4uw	2768	16	of	of	IN
cord-001835-0s7ok4uw	2768	17	the	the	DT
cord-001835-0s7ok4uw	2768	18	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2768	19	.	.	.
cord-001835-0s7ok4uw	2769	1	Increase	increase	VB
cord-001835-0s7ok4uw	2769	2	in	in	IN
cord-001835-0s7ok4uw	2769	3	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2769	4	concentration	concentration	NN
cord-001835-0s7ok4uw	2769	5	reduced	reduce	VBD
cord-001835-0s7ok4uw	2769	6	the	the	DT
cord-001835-0s7ok4uw	2769	7	observed	observed	JJ
cord-001835-0s7ok4uw	2769	8	rate	rate	NN
cord-001835-0s7ok4uw	2769	9	,	,	,
cord-001835-0s7ok4uw	2769	10	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2769	11	redox	redox	JJ
cord-001835-0s7ok4uw	2769	12	potential	potential	NN
cord-001835-0s7ok4uw	2769	13	of	of	IN
cord-001835-0s7ok4uw	2769	14	RpFNR	RpFNR	NNP
cord-001835-0s7ok4uw	2769	15	was	be	VBD
cord-001835-0s7ok4uw	2769	16	similar	similar	JJ
cord-001835-0s7ok4uw	2769	17	to	to	IN
cord-001835-0s7ok4uw	2769	18	that	that	DT
cord-001835-0s7ok4uw	2769	19	of	of	IN
cord-001835-0s7ok4uw	2769	20	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	2769	21	/	/	SYM
cord-001835-0s7ok4uw	2769	22	H	H	NNP
cord-001835-0s7ok4uw	2769	23	couple	couple	NN
cord-001835-0s7ok4uw	2769	24	in	in	IN
cord-001835-0s7ok4uw	2769	25	the	the	DT
cord-001835-0s7ok4uw	2769	26	presence	presence	NN
cord-001835-0s7ok4uw	2769	27	of	of	IN
cord-001835-0s7ok4uw	2769	28	excess	excess	JJ
cord-001835-0s7ok4uw	2769	29	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2769	30	.	.	.
cord-001835-0s7ok4uw	2770	1	Mixing	mix	VBG
cord-001835-0s7ok4uw	2770	2	photochemically	photochemically	RB
cord-001835-0s7ok4uw	2770	3	reduced	reduce	VBD
cord-001835-0s7ok4uw	2770	4	RpFNR	rpfnr	NN
cord-001835-0s7ok4uw	2770	5	with	with	IN
cord-001835-0s7ok4uw	2770	6	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	2770	7	rapidly	rapidly	RB
cord-001835-0s7ok4uw	2770	8	provided	provide	VBD
cord-001835-0s7ok4uw	2770	9	CTCs	ctc	NNS
cord-001835-0s7ok4uw	2770	10	.	.	.
cord-001835-0s7ok4uw	2771	1	The	the	DT
cord-001835-0s7ok4uw	2771	2	decay	decay	NN
cord-001835-0s7ok4uw	2771	3	corresponding	correspond	VBG
cord-001835-0s7ok4uw	2771	4	to	to	IN
cord-001835-0s7ok4uw	2771	5	the	the	DT
cord-001835-0s7ok4uw	2771	6	reoxidation	reoxidation	NN
cord-001835-0s7ok4uw	2771	7	of	of	IN
cord-001835-0s7ok4uw	2771	8	reduced	reduce	VBN
cord-001835-0s7ok4uw	2771	9	RpFNR	RpFNR	NNP
cord-001835-0s7ok4uw	2771	10	with	with	IN
cord-001835-0s7ok4uw	2771	11	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	2771	12	involved	involve	VBD
cord-001835-0s7ok4uw	2771	13	two	two	CD
cord-001835-0s7ok4uw	2771	14	distinctive	distinctive	JJ
cord-001835-0s7ok4uw	2771	15	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	2771	16	phases	phase	NNS
cord-001835-0s7ok4uw	2771	17	,	,	,
cord-001835-0s7ok4uw	2771	18	which	which	WDT
cord-001835-0s7ok4uw	2771	19	would	would	MD
cord-001835-0s7ok4uw	2771	20	be	be	VB
cord-001835-0s7ok4uw	2771	21	due	due	JJ
cord-001835-0s7ok4uw	2771	22	to	to	IN
cord-001835-0s7ok4uw	2771	23	the	the	DT
cord-001835-0s7ok4uw	2771	24	similarity	similarity	NN
cord-001835-0s7ok4uw	2771	25	in	in	IN
cord-001835-0s7ok4uw	2771	26	hydride	hydride	NN
cord-001835-0s7ok4uw	2771	27	transfer	transfer	NN
cord-001835-0s7ok4uw	2771	28	rates	rate	NNS
cord-001835-0s7ok4uw	2771	29	of	of	IN
cord-001835-0s7ok4uw	2771	30	forward	forward	RB
cord-001835-0s7ok4uw	2771	31	and	and	CC
cord-001835-0s7ok4uw	2771	32	reverse	reverse	VB
cord-001835-0s7ok4uw	2771	33	directions	direction	NNS
cord-001835-0s7ok4uw	2771	34	,	,	,
cord-001835-0s7ok4uw	2771	35	and	and	CC
cord-001835-0s7ok4uw	2771	36	the	the	DT
cord-001835-0s7ok4uw	2771	37	presence	presence	NN
cord-001835-0s7ok4uw	2771	38	of	of	IN
cord-001835-0s7ok4uw	2771	39	excess	excess	JJ
cord-001835-0s7ok4uw	2771	40	amount	amount	NN
cord-001835-0s7ok4uw	2771	41	of	of	IN
cord-001835-0s7ok4uw	2771	42	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	2771	43	.	.	.
cord-001835-0s7ok4uw	2772	1	Kinetic	kinetic	JJ
cord-001835-0s7ok4uw	2772	2	analyses	analysis	NNS
cord-001835-0s7ok4uw	2772	3	indicated	indicate	VBD
cord-001835-0s7ok4uw	2772	4	that	that	IN
cord-001835-0s7ok4uw	2772	5	the	the	DT
cord-001835-0s7ok4uw	2772	6	rate	rate	NN
cord-001835-0s7ok4uw	2772	7	-	-	HYPH
cord-001835-0s7ok4uw	2772	8	determining	determine	VBG
cord-001835-0s7ok4uw	2772	9	steps	step	NNS
cord-001835-0s7ok4uw	2772	10	were	be	VBD
cord-001835-0s7ok4uw	2772	11	the	the	DT
cord-001835-0s7ok4uw	2772	12	hydride	hydride	NN
cord-001835-0s7ok4uw	2772	13	-	-	HYPH
cord-001835-0s7ok4uw	2772	14	transfer	transfer	NN
cord-001835-0s7ok4uw	2772	15	reactions	reaction	NNS
cord-001835-0s7ok4uw	2772	16	in	in	IN
cord-001835-0s7ok4uw	2772	17	both	both	DT
cord-001835-0s7ok4uw	2772	18	directions	direction	NNS
cord-001835-0s7ok4uw	2772	19	and	and	CC
cord-001835-0s7ok4uw	2772	20	the	the	DT
cord-001835-0s7ok4uw	2772	21	rate	rate	NN
cord-001835-0s7ok4uw	2772	22	for	for	IN
cord-001835-0s7ok4uw	2772	23	the	the	DT
cord-001835-0s7ok4uw	2772	24	forward	forward	JJ
cord-001835-0s7ok4uw	2772	25	direction	direction	NN
cord-001835-0s7ok4uw	2772	26	was	be	VBD
cord-001835-0s7ok4uw	2772	27	close	close	JJ
cord-001835-0s7ok4uw	2772	28	to	to	IN
cord-001835-0s7ok4uw	2772	29	that	that	DT
cord-001835-0s7ok4uw	2772	30	for	for	IN
cord-001835-0s7ok4uw	2772	31	the	the	DT
cord-001835-0s7ok4uw	2772	32	reverse	reverse	JJ
cord-001835-0s7ok4uw	2772	33	direction	direction	NN
cord-001835-0s7ok4uw	2772	34	.	.	.
cord-001835-0s7ok4uw	2773	1	Obtained	obtain	VBN
cord-001835-0s7ok4uw	2773	2	data	datum	NNS
cord-001835-0s7ok4uw	2773	3	suggested	suggest	VBD
cord-001835-0s7ok4uw	2773	4	BsFNR	BsFNR	NNP
cord-001835-0s7ok4uw	2774	1	and	and	CC
cord-001835-0s7ok4uw	2774	2	RpFNR	rpfnr	NN
cord-001835-0s7ok4uw	2774	3	are	be	VBP
cord-001835-0s7ok4uw	2774	4	optimized	optimize	VBN
cord-001835-0s7ok4uw	2774	5	for	for	IN
cord-001835-0s7ok4uw	2774	6	different	different	JJ
cord-001835-0s7ok4uw	2774	7	direction	direction	NN
cord-001835-0s7ok4uw	2774	8	of	of	IN
cord-001835-0s7ok4uw	2774	9	the	the	DT
cord-001835-0s7ok4uw	2774	10	reaction	reaction	NN
cord-001835-0s7ok4uw	2774	11	and	and	CC
cord-001835-0s7ok4uw	2774	12	may	may	MD
cord-001835-0s7ok4uw	2774	13	play	play	VB
cord-001835-0s7ok4uw	2774	14	different	different	JJ
cord-001835-0s7ok4uw	2774	15	physiological	physiological	JJ
cord-001835-0s7ok4uw	2774	16	roles	role	NNS
cord-001835-0s7ok4uw	2774	17	.	.	.
cord-001835-0s7ok4uw	2775	1	Stephan	Stephan	NNP
cord-001835-0s7ok4uw	2775	2	K€	K€	NNP
cord-001835-0s7ok4uw	2775	3	ohler	ohler	NN
cord-001835-0s7ok4uw	2775	4	1,2	1,2	CD
cord-001835-0s7ok4uw	2775	5	,	,	,
cord-001835-0s7ok4uw	2775	6	Friederike	Friederike	NNP
cord-001835-0s7ok4uw	2775	7	Schmid	Schmid	NNP
cord-001835-0s7ok4uw	2775	8	1	1	CD
cord-001835-0s7ok4uw	2775	9	,	,	,
cord-001835-0s7ok4uw	2775	10	Giovanni	Giovanni	NNP
cord-001835-0s7ok4uw	2775	11	Settanni	Settanni	NNP
cord-001835-0s7ok4uw	2775	12	1,3	1,3	CD
cord-001835-0s7ok4uw	2775	13	1	1	CD
cord-001835-0s7ok4uw	2775	14	Institute	Institute	NNP
cord-001835-0s7ok4uw	2775	15	of	of	IN
cord-001835-0s7ok4uw	2775	16	Physics	Physics	NNP
cord-001835-0s7ok4uw	2775	17	,	,	,
cord-001835-0s7ok4uw	2775	18	Johannes	Johannes	NNP
cord-001835-0s7ok4uw	2775	19	Gutenberg	Gutenberg	NNP
cord-001835-0s7ok4uw	2775	20	University	University	NNP
cord-001835-0s7ok4uw	2775	21	Mainz	Mainz	NNP
cord-001835-0s7ok4uw	2775	22	,	,	,
cord-001835-0s7ok4uw	2775	23	Germany	Germany	NNP
cord-001835-0s7ok4uw	2775	24	,	,	,
cord-001835-0s7ok4uw	2775	25	2	2	CD
cord-001835-0s7ok4uw	2775	26	Graduate	Graduate	NNP
cord-001835-0s7ok4uw	2775	27	School	School	NNP
cord-001835-0s7ok4uw	2775	28	Materials	Materials	NNP
cord-001835-0s7ok4uw	2775	29	Science	Science	NNP
cord-001835-0s7ok4uw	2775	30	in	in	IN
cord-001835-0s7ok4uw	2775	31	Mainz	Mainz	NNP
cord-001835-0s7ok4uw	2775	32	,	,	,
cord-001835-0s7ok4uw	2775	33	3	3	CD
cord-001835-0s7ok4uw	2775	34	 	 	_SP
cord-001835-0s7ok4uw	2775	35	Fibrinogen	Fibrinogen	NNP
cord-001835-0s7ok4uw	2775	36	is	be	VBZ
cord-001835-0s7ok4uw	2775	37	a	a	DT
cord-001835-0s7ok4uw	2775	38	serum	serum	NN
cord-001835-0s7ok4uw	2775	39	multi	multi	JJ
cord-001835-0s7ok4uw	2775	40	-	-	JJ
cord-001835-0s7ok4uw	2775	41	chain	chain	JJ
cord-001835-0s7ok4uw	2775	42	protein	protein	NN
cord-001835-0s7ok4uw	2775	43	which	which	WDT
cord-001835-0s7ok4uw	2775	44	,	,	,
cord-001835-0s7ok4uw	2775	45	when	when	WRB
cord-001835-0s7ok4uw	2775	46	activated	activate	VBN
cord-001835-0s7ok4uw	2775	47	,	,	,
cord-001835-0s7ok4uw	2775	48	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	2775	49	to	to	TO
cord-001835-0s7ok4uw	2775	50	form	form	VB
cord-001835-0s7ok4uw	2775	51	fibrin	fibrin	NN
cord-001835-0s7ok4uw	2775	52	,	,	,
cord-001835-0s7ok4uw	2775	53	one	one	CD
cord-001835-0s7ok4uw	2775	54	of	of	IN
cord-001835-0s7ok4uw	2775	55	the	the	DT
cord-001835-0s7ok4uw	2775	56	main	main	JJ
cord-001835-0s7ok4uw	2775	57	components	component	NNS
cord-001835-0s7ok4uw	2775	58	of	of	IN
cord-001835-0s7ok4uw	2775	59	a	a	DT
cord-001835-0s7ok4uw	2775	60	blood	blood	NN
cord-001835-0s7ok4uw	2775	61	clot	clot	NN
cord-001835-0s7ok4uw	2775	62	.	.	.
cord-001835-0s7ok4uw	2776	1	Fibrinolysis	fibrinolysis	NN
cord-001835-0s7ok4uw	2776	2	controls	control	VBZ
cord-001835-0s7ok4uw	2776	3	blood	blood	NN
cord-001835-0s7ok4uw	2776	4	clot	clot	NN
cord-001835-0s7ok4uw	2776	5	dissolution	dissolution	NN
cord-001835-0s7ok4uw	2776	6	through	through	IN
cord-001835-0s7ok4uw	2776	7	the	the	DT
cord-001835-0s7ok4uw	2776	8	action	action	NN
cord-001835-0s7ok4uw	2776	9	of	of	IN
cord-001835-0s7ok4uw	2776	10	the	the	DT
cord-001835-0s7ok4uw	2776	11	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2776	12	plasmin	plasmin	NNP
cord-001835-0s7ok4uw	2776	13	,	,	,
cord-001835-0s7ok4uw	2776	14	which	which	WDT
cord-001835-0s7ok4uw	2776	15	cleaves	cleave	VBZ
cord-001835-0s7ok4uw	2776	16	fibrin	fibrin	NN
cord-001835-0s7ok4uw	2776	17	at	at	IN
cord-001835-0s7ok4uw	2776	18	specific	specific	JJ
cord-001835-0s7ok4uw	2776	19	locations	location	NNS
cord-001835-0s7ok4uw	2776	20	.	.	.
cord-001835-0s7ok4uw	2777	1	Although	although	IN
cord-001835-0s7ok4uw	2777	2	the	the	DT
cord-001835-0s7ok4uw	2777	3	main	main	JJ
cord-001835-0s7ok4uw	2777	4	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	2777	5	factors	factor	NNS
cord-001835-0s7ok4uw	2777	6	involved	involve	VBN
cord-001835-0s7ok4uw	2777	7	in	in	IN
cord-001835-0s7ok4uw	2777	8	fibrin	fibrin	NN
cord-001835-0s7ok4uw	2777	9	formation	formation	NN
cord-001835-0s7ok4uw	2777	10	and	and	CC
cord-001835-0s7ok4uw	2777	11	lysis	lysis	NN
cord-001835-0s7ok4uw	2777	12	have	have	VBP
cord-001835-0s7ok4uw	2777	13	been	be	VBN
cord-001835-0s7ok4uw	2777	14	identified	identify	VBN
cord-001835-0s7ok4uw	2777	15	,	,	,
cord-001835-0s7ok4uw	2777	16	a	a	DT
cord-001835-0s7ok4uw	2777	17	clear	clear	JJ
cord-001835-0s7ok4uw	2777	18	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	2777	19	picture	picture	NN
cord-001835-0s7ok4uw	2777	20	of	of	IN
cord-001835-0s7ok4uw	2777	21	how	how	WRB
cord-001835-0s7ok4uw	2777	22	these	these	DT
cord-001835-0s7ok4uw	2777	23	processes	process	NNS
cord-001835-0s7ok4uw	2777	24	take	take	VBP
cord-001835-0s7ok4uw	2777	25	place	place	NN
cord-001835-0s7ok4uw	2777	26	is	be	VBZ
cord-001835-0s7ok4uw	2777	27	not	not	RB
cord-001835-0s7ok4uw	2777	28	available	available	JJ
cord-001835-0s7ok4uw	2777	29	yet	yet	RB
cord-001835-0s7ok4uw	2777	30	.	.	.
cord-001835-0s7ok4uw	2778	1	This	this	DT
cord-001835-0s7ok4uw	2778	2	picture	picture	NN
cord-001835-0s7ok4uw	2778	3	would	would	MD
cord-001835-0s7ok4uw	2778	4	be	be	VB
cord-001835-0s7ok4uw	2778	5	instrumental	instrumental	JJ
cord-001835-0s7ok4uw	2778	6	,	,	,
cord-001835-0s7ok4uw	2778	7	for	for	IN
cord-001835-0s7ok4uw	2778	8	example	example	NN
cord-001835-0s7ok4uw	2778	9	,	,	,
cord-001835-0s7ok4uw	2778	10	for	for	IN
cord-001835-0s7ok4uw	2778	11	the	the	DT
cord-001835-0s7ok4uw	2778	12	design	design	NN
cord-001835-0s7ok4uw	2778	13	of	of	IN
cord-001835-0s7ok4uw	2778	14	improved	improved	JJ
cord-001835-0s7ok4uw	2778	15	thrombolytic	thrombolytic	JJ
cord-001835-0s7ok4uw	2778	16	or	or	CC
cord-001835-0s7ok4uw	2778	17	anti	anti	JJ
cord-001835-0s7ok4uw	2778	18	-	-	JJ
cord-001835-0s7ok4uw	2778	19	haemorrhagic	haemorrhagic	JJ
cord-001835-0s7ok4uw	2778	20	strategies	strategy	NNS
cord-001835-0s7ok4uw	2778	21	,	,	,
cord-001835-0s7ok4uw	2778	22	as	as	RB
cord-001835-0s7ok4uw	2778	23	well	well	RB
cord-001835-0s7ok4uw	2778	24	as	as	IN
cord-001835-0s7ok4uw	2778	25	,	,	,
cord-001835-0s7ok4uw	2778	26	materials	material	NNS
cord-001835-0s7ok4uw	2778	27	with	with	IN
cord-001835-0s7ok4uw	2778	28	improved	improve	VBN
cord-001835-0s7ok4uw	2778	29	biocompatibility	biocompatibility	NN
cord-001835-0s7ok4uw	2778	30	.	.	.
cord-001835-0s7ok4uw	2779	1	Here	here	RB
cord-001835-0s7ok4uw	2779	2	,	,	,
cord-001835-0s7ok4uw	2779	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2779	4	present	present	VBP
cord-001835-0s7ok4uw	2779	5	extensive	extensive	JJ
cord-001835-0s7ok4uw	2779	6	molecular	molecular	JJ
cord-001835-0s7ok4uw	2779	7	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2779	8	simulations	simulation	NNS
cord-001835-0s7ok4uw	2779	9	of	of	IN
cord-001835-0s7ok4uw	2779	10	the	the	DT
cord-001835-0s7ok4uw	2779	11	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	2779	12	complex	complex	NN
cord-001835-0s7ok4uw	2779	13	which	which	WDT
cord-001835-0s7ok4uw	2779	14	reveal	reveal	VBP
cord-001835-0s7ok4uw	2779	15	large	large	JJ
cord-001835-0s7ok4uw	2779	16	bending	bend	VBG
cord-001835-0s7ok4uw	2779	17	motions	motion	NNS
cord-001835-0s7ok4uw	2779	18	centered	center	VBN
cord-001835-0s7ok4uw	2779	19	at	at	IN
cord-001835-0s7ok4uw	2779	20	a	a	DT
cord-001835-0s7ok4uw	2779	21	hinge	hinge	NN
cord-001835-0s7ok4uw	2779	22	point	point	NN
cord-001835-0s7ok4uw	2779	23	in	in	IN
cord-001835-0s7ok4uw	2779	24	the	the	DT
cord-001835-0s7ok4uw	2779	25	coiled	coil	VBN
cord-001835-0s7ok4uw	2779	26	-	-	HYPH
cord-001835-0s7ok4uw	2779	27	coil	coil	NN
cord-001835-0s7ok4uw	2779	28	region	region	NN
cord-001835-0s7ok4uw	2779	29	of	of	IN
cord-001835-0s7ok4uw	2779	30	the	the	DT
cord-001835-0s7ok4uw	2779	31	complex	complex	NN
cord-001835-0s7ok4uw	2779	32	.	.	.
cord-001835-0s7ok4uw	2780	1	This	this	DT
cord-001835-0s7ok4uw	2780	2	feature	feature	NN
cord-001835-0s7ok4uw	2780	3	,	,	,
cord-001835-0s7ok4uw	2780	4	likely	likely	RB
cord-001835-0s7ok4uw	2780	5	conserved	conserve	VBN
cord-001835-0s7ok4uw	2780	6	across	across	IN
cord-001835-0s7ok4uw	2780	7	vertebrates	vertebrate	NNS
cord-001835-0s7ok4uw	2780	8	according	accord	VBG
cord-001835-0s7ok4uw	2780	9	to	to	IN
cord-001835-0s7ok4uw	2780	10	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2780	11	analysis	analysis	NN
cord-001835-0s7ok4uw	2780	12	,	,	,
cord-001835-0s7ok4uw	2780	13	suggests	suggest	VBZ
cord-001835-0s7ok4uw	2780	14	an	an	DT
cord-001835-0s7ok4uw	2780	15	explanation	explanation	NN
cord-001835-0s7ok4uw	2780	16	for	for	IN
cord-001835-0s7ok4uw	2780	17	the	the	DT
cord-001835-0s7ok4uw	2780	18	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2780	19	of	of	IN
cord-001835-0s7ok4uw	2780	20	exposure	exposure	NN
cord-001835-0s7ok4uw	2780	21	to	to	IN
cord-001835-0s7ok4uw	2780	22	lysis	lysis	NN
cord-001835-0s7ok4uw	2780	23	of	of	IN
cord-001835-0s7ok4uw	2780	24	the	the	DT
cord-001835-0s7ok4uw	2780	25	plasmin	plasmin	JJ
cord-001835-0s7ok4uw	2780	26	cleavage	cleavage	NN
cord-001835-0s7ok4uw	2780	27	sites	site	NNS
cord-001835-0s7ok4uw	2780	28	on	on	IN
cord-001835-0s7ok4uw	2780	29	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	2780	30	coiled	coil	VBN
cord-001835-0s7ok4uw	2780	31	-	-	HYPH
cord-001835-0s7ok4uw	2780	32	coil	coil	NN
cord-001835-0s7ok4uw	2780	33	region	region	NN
cord-001835-0s7ok4uw	2780	34	.	.	.
cord-001835-0s7ok4uw	2781	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2781	2	also	also	RB
cord-001835-0s7ok4uw	2781	3	explains	explain	VBZ
cord-001835-0s7ok4uw	2781	4	the	the	DT
cord-001835-0s7ok4uw	2781	5	conformational	conformational	JJ
cord-001835-0s7ok4uw	2781	6	variability	variability	NN
cord-001835-0s7ok4uw	2781	7	of	of	IN
cord-001835-0s7ok4uw	2781	8	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	2781	9	observed	observe	VBD
cord-001835-0s7ok4uw	2781	10	during	during	IN
cord-001835-0s7ok4uw	2781	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2781	12	adsorption	adsorption	NN
cord-001835-0s7ok4uw	2781	13	on	on	IN
cord-001835-0s7ok4uw	2781	14	inorganic	inorganic	JJ
cord-001835-0s7ok4uw	2781	15	surfaces	surface	NNS
cord-001835-0s7ok4uw	2781	16	and	and	CC
cord-001835-0s7ok4uw	2781	17	it	-PRON-	PRP
cord-001835-0s7ok4uw	2781	18	is	be	VBZ
cord-001835-0s7ok4uw	2781	19	supposed	suppose	VBN
cord-001835-0s7ok4uw	2781	20	to	to	TO
cord-001835-0s7ok4uw	2781	21	play	play	VB
cord-001835-0s7ok4uw	2781	22	a	a	DT
cord-001835-0s7ok4uw	2781	23	major	major	JJ
cord-001835-0s7ok4uw	2781	24	role	role	NN
cord-001835-0s7ok4uw	2781	25	in	in	IN
cord-001835-0s7ok4uw	2781	26	the	the	DT
cord-001835-0s7ok4uw	2781	27	determination	determination	NN
cord-001835-0s7ok4uw	2781	28	of	of	IN
cord-001835-0s7ok4uw	2781	29	the	the	DT
cord-001835-0s7ok4uw	2781	30	hydrodynamic	hydrodynamic	JJ
cord-001835-0s7ok4uw	2781	31	properties	property	NNS
cord-001835-0s7ok4uw	2781	32	of	of	IN
cord-001835-0s7ok4uw	2781	33	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	2781	34	.	.	.
cord-001835-0s7ok4uw	2782	1	In	in	IN
cord-001835-0s7ok4uw	2782	2	addition	addition	NN
cord-001835-0s7ok4uw	2782	3	the	the	DT
cord-001835-0s7ok4uw	2782	4	simulations	simulation	NNS
cord-001835-0s7ok4uw	2782	5	suggest	suggest	VBP
cord-001835-0s7ok4uw	2782	6	how	how	WRB
cord-001835-0s7ok4uw	2782	7	the	the	DT
cord-001835-0s7ok4uw	2782	8	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2782	9	of	of	IN
cord-001835-0s7ok4uw	2782	10	the	the	DT
cord-001835-0s7ok4uw	2782	11	D	D	NNP
cord-001835-0s7ok4uw	2782	12	region	region	NN
cord-001835-0s7ok4uw	2782	13	of	of	IN
cord-001835-0s7ok4uw	2782	14	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	2782	15	may	may	MD
cord-001835-0s7ok4uw	2782	16	contribute	contribute	VB
cord-001835-0s7ok4uw	2782	17	to	to	IN
cord-001835-0s7ok4uw	2782	18	the	the	DT
cord-001835-0s7ok4uw	2782	19	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2782	20	regulation	regulation	NN
cord-001835-0s7ok4uw	2782	21	of	of	IN
cord-001835-0s7ok4uw	2782	22	the	the	DT
cord-001835-0s7ok4uw	2782	23	blood	blood	NN
cord-001835-0s7ok4uw	2782	24	coagulation	coagulation	NN
cord-001835-0s7ok4uw	2782	25	cascade	cascade	VBP
cord-001835-0s7ok4uw	2782	26	through	through	IN
cord-001835-0s7ok4uw	2782	27	a	a	DT
cord-001835-0s7ok4uw	2782	28	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2782	29	coupling	coupling	NN
cord-001835-0s7ok4uw	2782	30	between	between	IN
cord-001835-0s7ok4uw	2782	31	the	the	DT
cord-001835-0s7ok4uw	2782	32	a	a	NN
cord-001835-0s7ok4uw	2782	33	-	-	:
cord-001835-0s7ok4uw	2782	34	and	and	CC
cord-001835-0s7ok4uw	2782	35	b	b	NN
cord-001835-0s7ok4uw	2782	36	-	-	:
cord-001835-0s7ok4uw	2782	37	holes	hole	NNS
cord-001835-0s7ok4uw	2782	38	,	,	,
cord-001835-0s7ok4uw	2782	39	important	important	JJ
cord-001835-0s7ok4uw	2782	40	for	for	IN
cord-001835-0s7ok4uw	2782	41	fibrin	fibrin	NN
cord-001835-0s7ok4uw	2782	42	polymerization	polymerization	NN
cord-001835-0s7ok4uw	2782	43	,	,	,
cord-001835-0s7ok4uw	2782	44	and	and	CC
cord-001835-0s7ok4uw	2782	45	the	the	DT
cord-001835-0s7ok4uw	2782	46	integrin	integrin	NN
cord-001835-0s7ok4uw	2782	47	binding	bind	VBG
cord-001835-0s7ok4uw	2782	48	site	site	NN
cord-001835-0s7ok4uw	2782	49	P1	P1	NNP
cord-001835-0s7ok4uw	2782	50	.	.	.
cord-001835-0s7ok4uw	2783	1	Membrane	membrane	NN
cord-001835-0s7ok4uw	2783	2	curvature	curvature	NN
cord-001835-0s7ok4uw	2783	3	-the	-the	ADD
cord-001835-0s7ok4uw	2783	4	assembler	assembler	NN
cord-001835-0s7ok4uw	2783	5	of	of	IN
cord-001835-0s7ok4uw	2783	6	proteins	protein	NNS
cord-001835-0s7ok4uw	2783	7	Mijo	Mijo	NNP
cord-001835-0s7ok4uw	2783	8	Simunovic	Simunovic	NNP
cord-001835-0s7ok4uw	2783	9	1,2	1,2	CD
cord-001835-0s7ok4uw	2783	10	,	,	,
cord-001835-0s7ok4uw	2783	11	Gregory	Gregory	NNP
cord-001835-0s7ok4uw	2783	12	Voth	Voth	NNP
cord-001835-0s7ok4uw	2783	13	1	1	CD
cord-001835-0s7ok4uw	2783	14	,	,	,
cord-001835-0s7ok4uw	2783	15	Patricia	Patricia	NNP
cord-001835-0s7ok4uw	2783	16	Bassereau	Bassereau	NNP
cord-001835-0s7ok4uw	2784	1	2	2	LS
cord-001835-0s7ok4uw	2784	2	1	1	CD
cord-001835-0s7ok4uw	2784	3	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	2784	4	Department	Department	NNP
cord-001835-0s7ok4uw	2784	5	,	,	,
cord-001835-0s7ok4uw	2784	6	The	the	DT
cord-001835-0s7ok4uw	2784	7	University	University	NNP
cord-001835-0s7ok4uw	2784	8	of	of	IN
cord-001835-0s7ok4uw	2784	9	Chicago	Chicago	NNP
cord-001835-0s7ok4uw	2784	10	,	,	,
cord-001835-0s7ok4uw	2784	11	2	2	CD
cord-001835-0s7ok4uw	2784	12	Physico	Physico	NNP
cord-001835-0s7ok4uw	2784	13	-	-	HYPH
cord-001835-0s7ok4uw	2784	14	Chimie	Chimie	NNP
cord-001835-0s7ok4uw	2784	15	Curie	Curie	NNP
cord-001835-0s7ok4uw	2784	16	,	,	,
cord-001835-0s7ok4uw	2784	17	Institut	Institut	NNP
cord-001835-0s7ok4uw	2784	18	Curie	Curie	NNP
cord-001835-0s7ok4uw	2785	1	Many	many	JJ
cord-001835-0s7ok4uw	2785	2	biological	biological	JJ
cord-001835-0s7ok4uw	2785	3	phenomena	phenomenon	NNS
cord-001835-0s7ok4uw	2785	4	require	require	VBP
cord-001835-0s7ok4uw	2785	5	the	the	DT
cord-001835-0s7ok4uw	2785	6	membrane	membrane	NN
cord-001835-0s7ok4uw	2785	7	to	to	TO
cord-001835-0s7ok4uw	2785	8	change	change	VB
cord-001835-0s7ok4uw	2785	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2785	10	shape	shape	NN
cord-001835-0s7ok4uw	2785	11	.	.	.
cord-001835-0s7ok4uw	2786	1	This	this	DT
cord-001835-0s7ok4uw	2786	2	process	process	NN
cord-001835-0s7ok4uw	2786	3	is	be	VBZ
cord-001835-0s7ok4uw	2786	4	often	often	RB
cord-001835-0s7ok4uw	2786	5	mediated	mediate	VBN
cord-001835-0s7ok4uw	2786	6	by	by	IN
cord-001835-0s7ok4uw	2786	7	curvature	curvature	NN
cord-001835-0s7ok4uw	2786	8	-	-	HYPH
cord-001835-0s7ok4uw	2786	9	generating	generate	VBG
cord-001835-0s7ok4uw	2786	10	proteins	protein	NNS
cord-001835-0s7ok4uw	2786	11	,	,	,
cord-001835-0s7ok4uw	2786	12	most	most	RBS
cord-001835-0s7ok4uw	2786	13	notably	notably	RB
cord-001835-0s7ok4uw	2786	14	by	by	IN
cord-001835-0s7ok4uw	2786	15	those	those	DT
cord-001835-0s7ok4uw	2786	16	containing	contain	VBG
cord-001835-0s7ok4uw	2786	17	one	one	CD
cord-001835-0s7ok4uw	2786	18	of	of	IN
cord-001835-0s7ok4uw	2786	19	many	many	JJ
cord-001835-0s7ok4uw	2786	20	BAR	bar	NN
cord-001835-0s7ok4uw	2786	21	domains	domain	NNS
cord-001835-0s7ok4uw	2786	22	.	.	.
cord-001835-0s7ok4uw	2787	1	At	at	IN
cord-001835-0s7ok4uw	2787	2	the	the	DT
cord-001835-0s7ok4uw	2787	3	same	same	JJ
cord-001835-0s7ok4uw	2787	4	time	time	NN
cord-001835-0s7ok4uw	2787	5	,	,	,
cord-001835-0s7ok4uw	2787	6	membrane	membrane	NN
cord-001835-0s7ok4uw	2787	7	curvature	curvature	NN
cord-001835-0s7ok4uw	2787	8	controls	control	VBZ
cord-001835-0s7ok4uw	2787	9	the	the	DT
cord-001835-0s7ok4uw	2787	10	way	way	NN
cord-001835-0s7ok4uw	2787	11	proteins	protein	NNS
cord-001835-0s7ok4uw	2787	12	interact	interact	VBP
cord-001835-0s7ok4uw	2787	13	with	with	IN
cord-001835-0s7ok4uw	2787	14	one	one	CD
cord-001835-0s7ok4uw	2787	15	another	another	DT
cord-001835-0s7ok4uw	2788	1	and	and	CC
cord-001835-0s7ok4uw	2788	2	so	so	RB
cord-001835-0s7ok4uw	2788	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	2788	4	acts	act	VBZ
cord-001835-0s7ok4uw	2788	5	as	as	IN
cord-001835-0s7ok4uw	2788	6	a	a	DT
cord-001835-0s7ok4uw	2788	7	vital	vital	JJ
cord-001835-0s7ok4uw	2788	8	signaling	signaling	NN
cord-001835-0s7ok4uw	2788	9	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2788	10	in	in	IN
cord-001835-0s7ok4uw	2788	11	the	the	DT
cord-001835-0s7ok4uw	2788	12	cell	cell	NN
cord-001835-0s7ok4uw	2788	13	.	.	.
cord-001835-0s7ok4uw	2789	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2789	2	combine	combine	VBP
cord-001835-0s7ok4uw	2789	3	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	2789	4	modeling	modeling	NN
cord-001835-0s7ok4uw	2789	5	with	with	IN
cord-001835-0s7ok4uw	2789	6	microscopy	microscopy	NN
cord-001835-0s7ok4uw	2789	7	imaging	imaging	NN
cord-001835-0s7ok4uw	2789	8	techniques	technique	NNS
cord-001835-0s7ok4uw	2789	9	to	to	TO
cord-001835-0s7ok4uw	2789	10	study	study	VB
cord-001835-0s7ok4uw	2789	11	the	the	DT
cord-001835-0s7ok4uw	2789	12	driving	drive	VBG
cord-001835-0s7ok4uw	2789	13	force	force	NN
cord-001835-0s7ok4uw	2789	14	underlying	underlie	VBG
cord-001835-0s7ok4uw	2789	15	the	the	DT
cord-001835-0s7ok4uw	2789	16	reshaping	reshaping	NN
cord-001835-0s7ok4uw	2789	17	of	of	IN
cord-001835-0s7ok4uw	2789	18	biological	biological	JJ
cord-001835-0s7ok4uw	2789	19	membranes	membrane	NNS
cord-001835-0s7ok4uw	2789	20	induced	induce	VBN
cord-001835-0s7ok4uw	2789	21	by	by	IN
cord-001835-0s7ok4uw	2789	22	N	n	CD
cord-001835-0s7ok4uw	2789	23	-	-	HYPH
cord-001835-0s7ok4uw	2789	24	BAR	bar	NN
cord-001835-0s7ok4uw	2789	25	proteins	protein	NNS
cord-001835-0s7ok4uw	2789	26	.	.	.
cord-001835-0s7ok4uw	2790	1	In	in	IN
cord-001835-0s7ok4uw	2790	2	particular	particular	JJ
cord-001835-0s7ok4uw	2790	3	,	,	,
cord-001835-0s7ok4uw	2790	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	2790	5	employ	employ	VBP
cord-001835-0s7ok4uw	2790	6	a	a	DT
cord-001835-0s7ok4uw	2790	7	combination	combination	NN
cord-001835-0s7ok4uw	2790	8	of	of	IN
cord-001835-0s7ok4uw	2790	9	coarse	coarse	RB
cord-001835-0s7ok4uw	2790	10	-	-	HYPH
cord-001835-0s7ok4uw	2790	11	grained	grained	JJ
cord-001835-0s7ok4uw	2790	12	molecular	molecular	JJ
cord-001835-0s7ok4uw	2790	13	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2790	14	with	with	IN
cord-001835-0s7ok4uw	2790	15	field	field	NN
cord-001835-0s7ok4uw	2790	16	-	-	HYPH
cord-001835-0s7ok4uw	2790	17	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	2790	18	simulation	simulation	NN
cord-001835-0s7ok4uw	2790	19	methods	method	NNS
cord-001835-0s7ok4uw	2790	20	to	to	TO
cord-001835-0s7ok4uw	2790	21	study	study	VB
cord-001835-0s7ok4uw	2790	22	the	the	DT
cord-001835-0s7ok4uw	2790	23	assembly	assembly	NN
cord-001835-0s7ok4uw	2790	24	of	of	IN
cord-001835-0s7ok4uw	2790	25	proteins	protein	NNS
cord-001835-0s7ok4uw	2790	26	on	on	IN
cord-001835-0s7ok4uw	2790	27	the	the	DT
cord-001835-0s7ok4uw	2790	28	membrane	membrane	NN
cord-001835-0s7ok4uw	2790	29	at	at	IN
cord-001835-0s7ok4uw	2790	30	molecular	molecular	JJ
cord-001835-0s7ok4uw	2790	31	resolution	resolution	NN
cord-001835-0s7ok4uw	2790	32	.	.	.
cord-001835-0s7ok4uw	2791	1	This	this	DT
cord-001835-0s7ok4uw	2791	2	approach	approach	NN
cord-001835-0s7ok4uw	2791	3	allowed	allow	VBD
cord-001835-0s7ok4uw	2791	4	us	-PRON-	PRP
cord-001835-0s7ok4uw	2791	5	to	to	TO
cord-001835-0s7ok4uw	2791	6	elucidate	elucidate	VB
cord-001835-0s7ok4uw	2791	7	the	the	DT
cord-001835-0s7ok4uw	2791	8	precise	precise	JJ
cord-001835-0s7ok4uw	2791	9	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2791	10	by	by	IN
cord-001835-0s7ok4uw	2791	11	which	which	WDT
cord-001835-0s7ok4uw	2791	12	cell	cell	NN
cord-001835-0s7ok4uw	2791	13	membranes	membrane	NNS
cord-001835-0s7ok4uw	2791	14	rapidly	rapidly	RB
cord-001835-0s7ok4uw	2791	15	and	and	CC
cord-001835-0s7ok4uw	2791	16	from	from	IN
cord-001835-0s7ok4uw	2791	17	large	large	JJ
cord-001835-0s7ok4uw	2791	18	distances	distance	NNS
cord-001835-0s7ok4uw	2791	19	recruit	recruit	VBP
cord-001835-0s7ok4uw	2791	20	proteins	protein	NNS
cord-001835-0s7ok4uw	2791	21	to	to	IN
cord-001835-0s7ok4uw	2791	22	membrane	membrane	NN
cord-001835-0s7ok4uw	2791	23	-	-	HYPH
cord-001835-0s7ok4uw	2791	24	reshaping	reshape	VBG
cord-001835-0s7ok4uw	2791	25	sites	site	NNS
cord-001835-0s7ok4uw	2791	26	.	.	.
cord-001835-0s7ok4uw	2792	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2792	2	also	also	RB
cord-001835-0s7ok4uw	2792	3	let	let	VBD
cord-001835-0s7ok4uw	2792	4	us	-PRON-	PRP
cord-001835-0s7ok4uw	2792	5	identify	identify	VB
cord-001835-0s7ok4uw	2792	6	a	a	DT
cord-001835-0s7ok4uw	2792	7	surprising	surprising	JJ
cord-001835-0s7ok4uw	2792	8	role	role	NN
cord-001835-0s7ok4uw	2792	9	of	of	IN
cord-001835-0s7ok4uw	2792	10	membrane	membrane	NN
cord-001835-0s7ok4uw	2792	11	tension	tension	NN
cord-001835-0s7ok4uw	2792	12	in	in	IN
cord-001835-0s7ok4uw	2792	13	directing	direct	VBG
cord-001835-0s7ok4uw	2792	14	the	the	DT
cord-001835-0s7ok4uw	2792	15	strength	strength	NN
cord-001835-0s7ok4uw	2792	16	and	and	CC
cord-001835-0s7ok4uw	2792	17	geometry	geometry	NN
cord-001835-0s7ok4uw	2792	18	of	of	IN
cord-001835-0s7ok4uw	2792	19	protein	protein	NN
cord-001835-0s7ok4uw	2792	20	-	-	HYPH
cord-001835-0s7ok4uw	2792	21	protein	protein	NN
cord-001835-0s7ok4uw	2792	22	interactions	interaction	NNS
cord-001835-0s7ok4uw	2792	23	.	.	.
cord-001835-0s7ok4uw	2793	1	By	by	IN
cord-001835-0s7ok4uw	2793	2	complementing	complement	VBG
cord-001835-0s7ok4uw	2793	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2793	4	simulations	simulation	NNS
cord-001835-0s7ok4uw	2793	5	with	with	IN
cord-001835-0s7ok4uw	2793	6	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	2793	7	and	and	CC
cord-001835-0s7ok4uw	2793	8	atomic	atomic	JJ
cord-001835-0s7ok4uw	2793	9	force	force	NN
cord-001835-0s7ok4uw	2793	10	microscopies	microscopy	NNS
cord-001835-0s7ok4uw	2793	11	,	,	,
cord-001835-0s7ok4uw	2793	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	2793	13	study	study	VBP
cord-001835-0s7ok4uw	2793	14	the	the	DT
cord-001835-0s7ok4uw	2793	15	way	way	NN
cord-001835-0s7ok4uw	2793	16	molecular	molecular	JJ
cord-001835-0s7ok4uw	2793	17	assembly	assembly	NN
cord-001835-0s7ok4uw	2793	18	of	of	IN
cord-001835-0s7ok4uw	2793	19	proteins	protein	NNS
cord-001835-0s7ok4uw	2793	20	affects	affect	VBZ
cord-001835-0s7ok4uw	2793	21	the	the	DT
cord-001835-0s7ok4uw	2793	22	membrane	membrane	NN
cord-001835-0s7ok4uw	2793	23	morphology	morphology	NN
cord-001835-0s7ok4uw	2793	24	at	at	IN
cord-001835-0s7ok4uw	2793	25	a	a	DT
cord-001835-0s7ok4uw	2793	26	more	more	RBR
cord-001835-0s7ok4uw	2793	27	macroscopic	macroscopic	JJ
cord-001835-0s7ok4uw	2793	28	level	level	NN
cord-001835-0s7ok4uw	2793	29	.	.	.
cord-001835-0s7ok4uw	2794	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2794	2	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	2794	3	how	how	WRB
cord-001835-0s7ok4uw	2794	4	largescale	largescale	JJ
cord-001835-0s7ok4uw	2794	5	ordering	ordering	NN
cord-001835-0s7ok4uw	2794	6	of	of	IN
cord-001835-0s7ok4uw	2794	7	the	the	DT
cord-001835-0s7ok4uw	2794	8	proteins	protein	NNS
cord-001835-0s7ok4uw	2794	9	on	on	IN
cord-001835-0s7ok4uw	2794	10	the	the	DT
cord-001835-0s7ok4uw	2794	11	membrane	membrane	NN
cord-001835-0s7ok4uw	2794	12	is	be	VBZ
cord-001835-0s7ok4uw	2794	13	mediated	mediate	VBN
cord-001835-0s7ok4uw	2794	14	by	by	IN
cord-001835-0s7ok4uw	2794	15	a	a	DT
cord-001835-0s7ok4uw	2794	16	strikingly	strikingly	RB
cord-001835-0s7ok4uw	2794	17	long	long	JJ
cord-001835-0s7ok4uw	2794	18	-	-	HYPH
cord-001835-0s7ok4uw	2794	19	range	range	NN
cord-001835-0s7ok4uw	2794	20	interaction	interaction	NN
cord-001835-0s7ok4uw	2794	21	that	that	WDT
cord-001835-0s7ok4uw	2794	22	is	be	VBZ
cord-001835-0s7ok4uw	2794	23	driven	drive	VBN
cord-001835-0s7ok4uw	2794	24	by	by	IN
cord-001835-0s7ok4uw	2794	25	membrane	membrane	NN
cord-001835-0s7ok4uw	2794	26	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	2794	27	.	.	.
cord-001835-0s7ok4uw	2795	1	In	in	IN
cord-001835-0s7ok4uw	2795	2	sum	sum	NN
cord-001835-0s7ok4uw	2795	3	,	,	,
cord-001835-0s7ok4uw	2795	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2795	5	combined	combined	JJ
cord-001835-0s7ok4uw	2795	6	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	2795	7	and	and	CC
cord-001835-0s7ok4uw	2795	8	experimental	experimental	JJ
cord-001835-0s7ok4uw	2795	9	approach	approach	NN
cord-001835-0s7ok4uw	2795	10	gives	give	VBZ
cord-001835-0s7ok4uw	2795	11	vital	vital	JJ
cord-001835-0s7ok4uw	2795	12	clues	clue	NNS
cord-001835-0s7ok4uw	2795	13	on	on	IN
cord-001835-0s7ok4uw	2795	14	how	how	WRB
cord-001835-0s7ok4uw	2795	15	the	the	DT
cord-001835-0s7ok4uw	2795	16	mechanical	mechanical	JJ
cord-001835-0s7ok4uw	2795	17	properties	property	NNS
cord-001835-0s7ok4uw	2795	18	of	of	IN
cord-001835-0s7ok4uw	2795	19	the	the	DT
cord-001835-0s7ok4uw	2795	20	membrane	membrane	NN
cord-001835-0s7ok4uw	2795	21	may	may	MD
cord-001835-0s7ok4uw	2795	22	regulate	regulate	VB
cord-001835-0s7ok4uw	2795	23	protein	protein	NN
cord-001835-0s7ok4uw	2795	24	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2795	25	in	in	IN
cord-001835-0s7ok4uw	2795	26	living	living	NN
cord-001835-0s7ok4uw	2795	27	cells	cell	NNS
cord-001835-0s7ok4uw	2795	28	.	.	.
cord-001835-0s7ok4uw	2796	1	Adnan	Adnan	NNP
cord-001835-0s7ok4uw	2796	2	Sljoka	Sljoka	NNP
cord-001835-0s7ok4uw	2796	3	1	1	CD
cord-001835-0s7ok4uw	2796	4	,	,	,
cord-001835-0s7ok4uw	2796	5	Alexandr	Alexandr	NNP
cord-001835-0s7ok4uw	2796	6	Bezginov	Bezginov	NNP
cord-001835-0s7ok4uw	2796	7	2	2	CD
cord-001835-0s7ok4uw	2796	8	1	1	CD
cord-001835-0s7ok4uw	2796	9	Kyoto	Kyoto	NNP
cord-001835-0s7ok4uw	2796	10	University	University	NNP
cord-001835-0s7ok4uw	2796	11	,	,	,
cord-001835-0s7ok4uw	2796	12	2	2	CD
cord-001835-0s7ok4uw	2796	13	University	University	NNP
cord-001835-0s7ok4uw	2796	14	of	of	IN
cord-001835-0s7ok4uw	2796	15	Toronto	Toronto	NNP
cord-001835-0s7ok4uw	2796	16	Understanding	Understanding	NNP
cord-001835-0s7ok4uw	2796	17	how	how	WRB
cord-001835-0s7ok4uw	2796	18	a	a	DT
cord-001835-0s7ok4uw	2796	19	protein	protein	NN
cord-001835-0s7ok4uw	2796	20	functions	function	NNS
cord-001835-0s7ok4uw	2796	21	depends	depend	VBZ
cord-001835-0s7ok4uw	2796	22	in	in	IN
cord-001835-0s7ok4uw	2796	23	critical	critical	JJ
cord-001835-0s7ok4uw	2796	24	ways	way	NNS
cord-001835-0s7ok4uw	2796	25	on	on	IN
cord-001835-0s7ok4uw	2796	26	predicting	predict	VBG
cord-001835-0s7ok4uw	2796	27	which	which	WDT
cord-001835-0s7ok4uw	2796	28	parts	part	NNS
cord-001835-0s7ok4uw	2796	29	are	be	VBP
cord-001835-0s7ok4uw	2796	30	rigid	rigid	JJ
cord-001835-0s7ok4uw	2796	31	and	and	CC
cord-001835-0s7ok4uw	2796	32	which	which	WDT
cord-001835-0s7ok4uw	2796	33	are	be	VBP
cord-001835-0s7ok4uw	2796	34	flexible	flexible	JJ
cord-001835-0s7ok4uw	2796	35	.	.	.
cord-001835-0s7ok4uw	2797	1	Using	use	VBG
cord-001835-0s7ok4uw	2797	2	rigidity	rigidity	NN
cord-001835-0s7ok4uw	2797	3	-	-	HYPH
cord-001835-0s7ok4uw	2797	4	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	2797	5	techniques	technique	NNS
cord-001835-0s7ok4uw	2797	6	,	,	,
cord-001835-0s7ok4uw	2797	7	a	a	DT
cord-001835-0s7ok4uw	2797	8	number	number	NN
cord-001835-0s7ok4uw	2797	9	or	or	CC
cord-001835-0s7ok4uw	2797	10	programs	program	NNS
cord-001835-0s7ok4uw	2797	11	such	such	JJ
cord-001835-0s7ok4uw	2797	12	as	as	IN
cord-001835-0s7ok4uw	2797	13	FIRST	first	JJ
cord-001835-0s7ok4uw	2797	14	,	,	,
cord-001835-0s7ok4uw	2797	15	ProFlex	ProFlex	NNP
cord-001835-0s7ok4uw	2797	16	or	or	CC
cord-001835-0s7ok4uw	2797	17	ABSTRACT	ABSTRACT	NNP
cord-001835-0s7ok4uw	2797	18	Kinari	Kinari	NNP
cord-001835-0s7ok4uw	2797	19	can	can	MD
cord-001835-0s7ok4uw	2797	20	rapidly	rapidly	RB
cord-001835-0s7ok4uw	2797	21	decompose	decompose	VB
cord-001835-0s7ok4uw	2797	22	a	a	DT
cord-001835-0s7ok4uw	2797	23	protein	protein	NN
cord-001835-0s7ok4uw	2797	24	into	into	IN
cord-001835-0s7ok4uw	2797	25	flexible	flexible	JJ
cord-001835-0s7ok4uw	2797	26	and	and	CC
cord-001835-0s7ok4uw	2797	27	rigid	rigid	JJ
cord-001835-0s7ok4uw	2797	28	regions	region	NNS
cord-001835-0s7ok4uw	2797	29	.	.	.
cord-001835-0s7ok4uw	2798	1	In	in	IN
cord-001835-0s7ok4uw	2798	2	this	this	DT
cord-001835-0s7ok4uw	2798	3	study	study	NN
cord-001835-0s7ok4uw	2798	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	2798	5	extend	extend	VBP
cord-001835-0s7ok4uw	2798	6	this	this	DT
cord-001835-0s7ok4uw	2798	7	technique	technique	NN
cord-001835-0s7ok4uw	2798	8	and	and	CC
cord-001835-0s7ok4uw	2798	9	develop	develop	VB
cord-001835-0s7ok4uw	2798	10	a	a	DT
cord-001835-0s7ok4uw	2798	11	novel	novel	JJ
cord-001835-0s7ok4uw	2798	12	computational	computational	JJ
cord-001835-0s7ok4uw	2798	13	approach	approach	NN
cord-001835-0s7ok4uw	2798	14	for	for	IN
cord-001835-0s7ok4uw	2798	15	detecting	detect	VBG
cord-001835-0s7ok4uw	2798	16	protein	protein	NN
cord-001835-0s7ok4uw	2798	17	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2798	18	interactions	interaction	NNS
cord-001835-0s7ok4uw	2798	19	.	.	.
cord-001835-0s7ok4uw	2799	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2799	2	is	be	VBZ
cord-001835-0s7ok4uw	2799	3	widely	widely	RB
cord-001835-0s7ok4uw	2799	4	believed	believe	VBN
cord-001835-0s7ok4uw	2799	5	that	that	IN
cord-001835-0s7ok4uw	2799	6	the	the	DT
cord-001835-0s7ok4uw	2799	7	binding	binding	NN
cord-001835-0s7ok4uw	2799	8	of	of	IN
cord-001835-0s7ok4uw	2799	9	a	a	DT
cord-001835-0s7ok4uw	2799	10	ligand	ligand	NN
cord-001835-0s7ok4uw	2799	11	at	at	IN
cord-001835-0s7ok4uw	2799	12	the	the	DT
cord-001835-0s7ok4uw	2799	13	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2799	14	site	site	NN
cord-001835-0s7ok4uw	2799	15	triggers	trigger	VBZ
cord-001835-0s7ok4uw	2799	16	a	a	DT
cord-001835-0s7ok4uw	2799	17	conformational	conformational	JJ
cord-001835-0s7ok4uw	2799	18	change	change	NN
cord-001835-0s7ok4uw	2799	19	that	that	WDT
cord-001835-0s7ok4uw	2799	20	is	be	VBZ
cord-001835-0s7ok4uw	2799	21	transmitted	transmit	VBN
cord-001835-0s7ok4uw	2799	22	through	through	IN
cord-001835-0s7ok4uw	2799	23	the	the	DT
cord-001835-0s7ok4uw	2799	24	protein	protein	NN
cord-001835-0s7ok4uw	2799	25	to	to	TO
cord-001835-0s7ok4uw	2799	26	cause	cause	VB
cord-001835-0s7ok4uw	2799	27	a	a	DT
cord-001835-0s7ok4uw	2799	28	rearrangement	rearrangement	NN
cord-001835-0s7ok4uw	2799	29	and	and	CC
cord-001835-0s7ok4uw	2799	30	alteration	alteration	NN
cord-001835-0s7ok4uw	2799	31	of	of	IN
cord-001835-0s7ok4uw	2799	32	the	the	DT
cord-001835-0s7ok4uw	2799	33	shape	shape	NN
cord-001835-0s7ok4uw	2799	34	of	of	IN
cord-001835-0s7ok4uw	2799	35	the	the	DT
cord-001835-0s7ok4uw	2799	36	active	active	JJ
cord-001835-0s7ok4uw	2799	37	site	site	NN
cord-001835-0s7ok4uw	2799	38	.	.	.
cord-001835-0s7ok4uw	2800	1	Allostery	Allostery	NNP
cord-001835-0s7ok4uw	2800	2	was	be	VBD
cord-001835-0s7ok4uw	2800	3	first	first	RB
cord-001835-0s7ok4uw	2800	4	described	describe	VBN
cord-001835-0s7ok4uw	2800	5	more	more	JJR
cord-001835-0s7ok4uw	2800	6	than	than	IN
cord-001835-0s7ok4uw	2800	7	50	50	CD
cord-001835-0s7ok4uw	2800	8	years	year	NNS
cord-001835-0s7ok4uw	2800	9	ago	ago	RB
cord-001835-0s7ok4uw	2800	10	;	;	:
cord-001835-0s7ok4uw	2800	11	however	however	RB
cord-001835-0s7ok4uw	2800	12	,	,	,
cord-001835-0s7ok4uw	2800	13	the	the	DT
cord-001835-0s7ok4uw	2800	14	underlying	underlie	VBG
cord-001835-0s7ok4uw	2800	15	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2800	16	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2800	17	is	be	VBZ
cord-001835-0s7ok4uw	2800	18	still	still	RB
cord-001835-0s7ok4uw	2800	19	not	not	RB
cord-001835-0s7ok4uw	2800	20	well	well	RB
cord-001835-0s7ok4uw	2800	21	understood	understand	VBN
cord-001835-0s7ok4uw	2800	22	.	.	.
cord-001835-0s7ok4uw	2801	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2801	2	will	will	MD
cord-001835-0s7ok4uw	2801	3	introduce	introduce	VB
cord-001835-0s7ok4uw	2801	4	a	a	DT
cord-001835-0s7ok4uw	2801	5	rigidity	rigidity	NN
cord-001835-0s7ok4uw	2801	6	-	-	HYPH
cord-001835-0s7ok4uw	2801	7	based	base	VBN
cord-001835-0s7ok4uw	2801	8	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2801	9	mode	mode	NN
cord-001835-0s7ok4uw	2801	10	of	of	IN
cord-001835-0s7ok4uw	2801	11	communication	communication	NN
cord-001835-0s7ok4uw	2801	12	together	together	RB
cord-001835-0s7ok4uw	2801	13	with	with	IN
cord-001835-0s7ok4uw	2801	14	an	an	DT
cord-001835-0s7ok4uw	2801	15	algorithm	algorithm	NN
cord-001835-0s7ok4uw	2801	16	which	which	WDT
cord-001835-0s7ok4uw	2801	17	can	can	MD
cord-001835-0s7ok4uw	2801	18	detect	detect	VB
cord-001835-0s7ok4uw	2801	19	transmission	transmission	NN
cord-001835-0s7ok4uw	2801	20	of	of	IN
cord-001835-0s7ok4uw	2801	21	rigidity	rigidity	NN
cord-001835-0s7ok4uw	2801	22	and	and	CC
cord-001835-0s7ok4uw	2801	23	shape	shape	NN
cord-001835-0s7ok4uw	2801	24	changes	change	NNS
cord-001835-0s7ok4uw	2801	25	between	between	IN
cord-001835-0s7ok4uw	2801	26	two	two	CD
cord-001835-0s7ok4uw	2801	27	(	(	-LRB-
cord-001835-0s7ok4uw	2801	28	or	or	CC
cord-001835-0s7ok4uw	2801	29	more	more	RBR
cord-001835-0s7ok4uw	2801	30	)	)	-RRB-
cord-001835-0s7ok4uw	2801	31	distant	distant	JJ
cord-001835-0s7ok4uw	2801	32	binding	bind	VBG
cord-001835-0s7ok4uw	2801	33	sites	site	NNS
cord-001835-0s7ok4uw	2801	34	in	in	IN
cord-001835-0s7ok4uw	2801	35	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2801	36	proteins	protein	NNS
cord-001835-0s7ok4uw	2801	37	.	.	.
cord-001835-0s7ok4uw	2802	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2802	2	algorithm	algorithm	NN
cord-001835-0s7ok4uw	2802	3	is	be	VBZ
cord-001835-0s7ok4uw	2802	4	also	also	RB
cord-001835-0s7ok4uw	2802	5	used	use	VBN
cord-001835-0s7ok4uw	2802	6	to	to	TO
cord-001835-0s7ok4uw	2802	7	predict	predict	VB
cord-001835-0s7ok4uw	2802	8	and	and	CC
cord-001835-0s7ok4uw	2802	9	identify	identify	VB
cord-001835-0s7ok4uw	2802	10	regions	region	NNS
cord-001835-0s7ok4uw	2802	11	in	in	IN
cord-001835-0s7ok4uw	2802	12	the	the	DT
cord-001835-0s7ok4uw	2802	13	protein	protein	NN
cord-001835-0s7ok4uw	2802	14	that	that	WDT
cord-001835-0s7ok4uw	2802	15	are	be	VBP
cord-001835-0s7ok4uw	2802	16	critical	critical	JJ
cord-001835-0s7ok4uw	2802	17	for	for	IN
cord-001835-0s7ok4uw	2802	18	the	the	DT
cord-001835-0s7ok4uw	2802	19	coupled	coupled	JJ
cord-001835-0s7ok4uw	2802	20	communication	communication	NN
cord-001835-0s7ok4uw	2802	21	between	between	IN
cord-001835-0s7ok4uw	2802	22	distant	distant	JJ
cord-001835-0s7ok4uw	2802	23	sites	site	NNS
cord-001835-0s7ok4uw	2802	24	(	(	-LRB-
cord-001835-0s7ok4uw	2802	25	i.e.	i.e.	FW
cord-001835-0s7ok4uw	2802	26	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2802	27	pathways	pathway	NNS
cord-001835-0s7ok4uw	2802	28	)	)	-RRB-
cord-001835-0s7ok4uw	2802	29	.	.	.
cord-001835-0s7ok4uw	2803	1	Starting	start	VBG
cord-001835-0s7ok4uw	2803	2	with	with	IN
cord-001835-0s7ok4uw	2803	3	a	a	DT
cord-001835-0s7ok4uw	2803	4	set	set	NN
cord-001835-0s7ok4uw	2803	5	of	of	IN
cord-001835-0s7ok4uw	2803	6	known	know	VBN
cord-001835-0s7ok4uw	2803	7	GPCR	GPCR	NNP
cord-001835-0s7ok4uw	2803	8	3-dimensional	3-dimensional	CD
cord-001835-0s7ok4uw	2803	9	structures	structure	NNS
cord-001835-0s7ok4uw	2803	10	,	,	,
cord-001835-0s7ok4uw	2803	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	2803	12	apply	apply	VBP
cord-001835-0s7ok4uw	2803	13	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2803	14	methods	method	NNS
cord-001835-0s7ok4uw	2803	15	and	and	CC
cord-001835-0s7ok4uw	2803	16	show	show	VB
cord-001835-0s7ok4uw	2803	17	how	how	WRB
cord-001835-0s7ok4uw	2803	18	binding	bind	VBG
cord-001835-0s7ok4uw	2803	19	of	of	IN
cord-001835-0s7ok4uw	2803	20	an	an	DT
cord-001835-0s7ok4uw	2803	21	activating	activate	VBG
cord-001835-0s7ok4uw	2803	22	ligand	ligand	NN
cord-001835-0s7ok4uw	2803	23	(	(	-LRB-
cord-001835-0s7ok4uw	2803	24	i.e.	i.e.	FW
cord-001835-0s7ok4uw	2803	25	agonist	agonist	NN
cord-001835-0s7ok4uw	2803	26	)	)	-RRB-
cord-001835-0s7ok4uw	2803	27	triggers	trigger	VBZ
cord-001835-0s7ok4uw	2803	28	small	small	JJ
cord-001835-0s7ok4uw	2803	29	rigidity	rigidity	NN
cord-001835-0s7ok4uw	2803	30	changes	change	NNS
cord-001835-0s7ok4uw	2803	31	which	which	WDT
cord-001835-0s7ok4uw	2803	32	propagate	propagate	VBP
cord-001835-0s7ok4uw	2803	33	to	to	IN
cord-001835-0s7ok4uw	2803	34	the	the	DT
cord-001835-0s7ok4uw	2803	35	critical	critical	JJ
cord-001835-0s7ok4uw	2803	36	G	g	NN
cord-001835-0s7ok4uw	2803	37	-	-	HYPH
cord-001835-0s7ok4uw	2803	38	protein	protein	NN
cord-001835-0s7ok4uw	2803	39	binding	binding	NN
cord-001835-0s7ok4uw	2803	40	regions	region	NNS
cord-001835-0s7ok4uw	2803	41	.	.	.
cord-001835-0s7ok4uw	2804	1	In	in	IN
cord-001835-0s7ok4uw	2804	2	contrast	contrast	NN
cord-001835-0s7ok4uw	2804	3	,	,	,
cord-001835-0s7ok4uw	2804	4	in	in	IN
cord-001835-0s7ok4uw	2804	5	the	the	DT
cord-001835-0s7ok4uw	2804	6	inactive	inactive	JJ
cord-001835-0s7ok4uw	2804	7	GPCR	GPCR	NNP
cord-001835-0s7ok4uw	2804	8	structures	structure	NNS
cord-001835-0s7ok4uw	2804	9	no	no	DT
cord-001835-0s7ok4uw	2804	10	such	such	JJ
cord-001835-0s7ok4uw	2804	11	rigidity	rigidity	NN
cord-001835-0s7ok4uw	2804	12	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2804	13	communication	communication	NN
cord-001835-0s7ok4uw	2804	14	is	be	VBZ
cord-001835-0s7ok4uw	2804	15	observed	observe	VBN
cord-001835-0s7ok4uw	2804	16	.	.	.
cord-001835-0s7ok4uw	2805	1	Detailed	detailed	JJ
cord-001835-0s7ok4uw	2805	2	predictions	prediction	NNS
cord-001835-0s7ok4uw	2805	3	and	and	CC
cord-001835-0s7ok4uw	2805	4	analysis	analysis	NN
cord-001835-0s7ok4uw	2805	5	on	on	IN
cord-001835-0s7ok4uw	2805	6	activated	activate	VBN
cord-001835-0s7ok4uw	2805	7	(	(	-LRB-
cord-001835-0s7ok4uw	2805	8	agonist	agonist	NN
cord-001835-0s7ok4uw	2805	9	-	-	HYPH
cord-001835-0s7ok4uw	2805	10	bound	bind	VBN
cord-001835-0s7ok4uw	2805	11	)	)	-RRB-
cord-001835-0s7ok4uw	2805	12	and	and	CC
cord-001835-0s7ok4uw	2805	13	inactive	inactive	JJ
cord-001835-0s7ok4uw	2805	14	adenosine	adenosine	NN
cord-001835-0s7ok4uw	2805	15	receptors	receptor	NNS
cord-001835-0s7ok4uw	2805	16	is	be	VBZ
cord-001835-0s7ok4uw	2805	17	discussed	discuss	VBN
cord-001835-0s7ok4uw	2805	18	and	and	CC
cord-001835-0s7ok4uw	2805	19	results	result	NNS
cord-001835-0s7ok4uw	2805	20	are	be	VBP
cord-001835-0s7ok4uw	2805	21	compared	compare	VBN
cord-001835-0s7ok4uw	2805	22	with	with	IN
cord-001835-0s7ok4uw	2805	23	experimental	experimental	JJ
cord-001835-0s7ok4uw	2805	24	evidence	evidence	NN
cord-001835-0s7ok4uw	2805	25	.	.	.
cord-001835-0s7ok4uw	2806	1	These	these	DT
cord-001835-0s7ok4uw	2806	2	results	result	NNS
cord-001835-0s7ok4uw	2806	3	show	show	VBP
cord-001835-0s7ok4uw	2806	4	that	that	IN
cord-001835-0s7ok4uw	2806	5	rigidity	rigidity	NN
cord-001835-0s7ok4uw	2806	6	-	-	HYPH
cord-001835-0s7ok4uw	2806	7	based	base	VBN
cord-001835-0s7ok4uw	2806	8	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2806	9	model	model	NN
cord-001835-0s7ok4uw	2806	10	and	and	CC
cord-001835-0s7ok4uw	2806	11	algorithm	algorithm	NN
cord-001835-0s7ok4uw	2806	12	is	be	VBZ
cord-001835-0s7ok4uw	2806	13	a	a	DT
cord-001835-0s7ok4uw	2806	14	powerful	powerful	JJ
cord-001835-0s7ok4uw	2806	15	new	new	JJ
cord-001835-0s7ok4uw	2806	16	tool	tool	NN
cord-001835-0s7ok4uw	2806	17	for	for	IN
cord-001835-0s7ok4uw	2806	18	detecting	detect	VBG
cord-001835-0s7ok4uw	2806	19	allostery	allostery	NN
cord-001835-0s7ok4uw	2806	20	in	in	IN
cord-001835-0s7ok4uw	2806	21	GPCRs	gpcr	NNS
cord-001835-0s7ok4uw	2806	22	.	.	.
cord-001835-0s7ok4uw	2807	1	Comparing	compare	VBG
cord-001835-0s7ok4uw	2807	2	the	the	DT
cord-001835-0s7ok4uw	2807	3	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	2807	4	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2807	5	of	of	IN
cord-001835-0s7ok4uw	2807	6	multiple	multiple	JJ
cord-001835-0s7ok4uw	2807	7	proteins	protein	NNS
cord-001835-0s7ok4uw	2807	8	using	use	VBG
cord-001835-0s7ok4uw	2807	9	elastic	elastic	JJ
cord-001835-0s7ok4uw	2807	10	network	network	NN
cord-001835-0s7ok4uw	2807	11	models	model	NNS
cord-001835-0s7ok4uw	2807	12	reveals	reveal	VBZ
cord-001835-0s7ok4uw	2807	13	global	global	JJ
cord-001835-0s7ok4uw	2807	14	similarities	similarity	NNS
cord-001835-0s7ok4uw	2807	15	based	base	VBN
cord-001835-0s7ok4uw	2807	16	on	on	IN
cord-001835-0s7ok4uw	2807	17	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2807	18	overall	overall	JJ
cord-001835-0s7ok4uw	2807	19	shape	shape	NN
cord-001835-0s7ok4uw	2807	20	Sandhya	Sandhya	NNP
cord-001835-0s7ok4uw	2807	21	Tiwari	Tiwari	NNP
cord-001835-0s7ok4uw	2807	22	1,2	1,2	CD
cord-001835-0s7ok4uw	2807	23	,	,	,
cord-001835-0s7ok4uw	2807	24	Nathalie	Nathalie	NNP
cord-001835-0s7ok4uw	2807	25	Reuter	Reuter	NNP
cord-001835-0s7ok4uw	2807	26	1,2	1,2	CD
cord-001835-0s7ok4uw	2807	27	1	1	CD
cord-001835-0s7ok4uw	2807	28	With	with	IN
cord-001835-0s7ok4uw	2807	29	increasing	increase	VBG
cord-001835-0s7ok4uw	2807	30	protein	protein	NN
cord-001835-0s7ok4uw	2807	31	structural	structural	JJ
cord-001835-0s7ok4uw	2807	32	data	datum	NNS
cord-001835-0s7ok4uw	2807	33	,	,	,
cord-001835-0s7ok4uw	2807	34	we	-PRON-	PRP
cord-001835-0s7ok4uw	2807	35	find	find	VBP
cord-001835-0s7ok4uw	2807	36	ourselves	-PRON-	PRP
cord-001835-0s7ok4uw	2807	37	with	with	IN
cord-001835-0s7ok4uw	2807	38	the	the	DT
cord-001835-0s7ok4uw	2807	39	opportunity	opportunity	NN
cord-001835-0s7ok4uw	2807	40	to	to	TO
cord-001835-0s7ok4uw	2807	41	study	study	VB
cord-001835-0s7ok4uw	2807	42	the	the	DT
cord-001835-0s7ok4uw	2807	43	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	2807	44	similarities	similarity	NNS
cord-001835-0s7ok4uw	2807	45	within	within	IN
cord-001835-0s7ok4uw	2807	46	large	large	JJ
cord-001835-0s7ok4uw	2807	47	ensembles	ensemble	NNS
cord-001835-0s7ok4uw	2807	48	in	in	IN
cord-001835-0s7ok4uw	2807	49	order	order	NN
cord-001835-0s7ok4uw	2807	50	to	to	TO
cord-001835-0s7ok4uw	2807	51	understand	understand	VB
cord-001835-0s7ok4uw	2807	52	the	the	DT
cord-001835-0s7ok4uw	2807	53	role	role	NN
cord-001835-0s7ok4uw	2807	54	of	of	IN
cord-001835-0s7ok4uw	2807	55	protein	protein	NN
cord-001835-0s7ok4uw	2807	56	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2807	57	at	at	IN
cord-001835-0s7ok4uw	2807	58	various	various	JJ
cord-001835-0s7ok4uw	2807	59	levels	level	NNS
cord-001835-0s7ok4uw	2807	60	.	.	.
cord-001835-0s7ok4uw	2808	1	Is	be	VBZ
cord-001835-0s7ok4uw	2808	2	there	there	EX
cord-001835-0s7ok4uw	2808	3	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	2808	4	pressure	pressure	NN
cord-001835-0s7ok4uw	2808	5	to	to	TO
cord-001835-0s7ok4uw	2808	6	conserve	conserve	VB
cord-001835-0s7ok4uw	2808	7	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2808	8	?	?	.
cord-001835-0s7ok4uw	2809	1	Is	be	VBZ
cord-001835-0s7ok4uw	2809	2	this	this	DT
cord-001835-0s7ok4uw	2809	3	necessary	necessary	JJ
cord-001835-0s7ok4uw	2809	4	to	to	TO
cord-001835-0s7ok4uw	2809	5	retain	retain	VB
cord-001835-0s7ok4uw	2809	6	functionality	functionality	NN
cord-001835-0s7ok4uw	2809	7	,	,	,
cord-001835-0s7ok4uw	2809	8	as	as	IN
cord-001835-0s7ok4uw	2809	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	2809	10	has	have	VBZ
cord-001835-0s7ok4uw	2809	11	been	be	VBN
cord-001835-0s7ok4uw	2809	12	suggested	suggest	VBN
cord-001835-0s7ok4uw	2809	13	?	?	.
cord-001835-0s7ok4uw	2810	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2810	2	performed	perform	VBD
cord-001835-0s7ok4uw	2810	3	strategic	strategic	JJ
cord-001835-0s7ok4uw	2810	4	comparative	comparative	JJ
cord-001835-0s7ok4uw	2810	5	analysis	analysis	NN
cord-001835-0s7ok4uw	2810	6	using	use	VBG
cord-001835-0s7ok4uw	2810	7	the	the	DT
cord-001835-0s7ok4uw	2810	8	elastic	elastic	JJ
cord-001835-0s7ok4uw	2810	9	network	network	NN
cord-001835-0s7ok4uw	2810	10	model	model	NN
cord-001835-0s7ok4uw	2810	11	,	,	,
cord-001835-0s7ok4uw	2810	12	which	which	WDT
cord-001835-0s7ok4uw	2810	13	has	have	VBZ
cord-001835-0s7ok4uw	2810	14	proven	prove	VBN
cord-001835-0s7ok4uw	2810	15	to	to	TO
cord-001835-0s7ok4uw	2810	16	be	be	VB
cord-001835-0s7ok4uw	2810	17	highly	highly	RB
cord-001835-0s7ok4uw	2810	18	efficient	efficient	JJ
cord-001835-0s7ok4uw	2810	19	and	and	CC
cord-001835-0s7ok4uw	2810	20	informative	informative	JJ
cord-001835-0s7ok4uw	2811	1	(	(	-LRB-
cord-001835-0s7ok4uw	2811	2	Fuglebakk	Fuglebakk	NNP
cord-001835-0s7ok4uw	2811	3	et	et	NNP
cord-001835-0s7ok4uw	2811	4	al	al	NNP
cord-001835-0s7ok4uw	2811	5	.	.	.
cord-001835-0s7ok4uw	2812	1	,	,	,
cord-001835-0s7ok4uw	2812	2	BMC	BMC	NNP
cord-001835-0s7ok4uw	2812	3	Bioinformatics	Bioinformatics	NNP
cord-001835-0s7ok4uw	2812	4	,	,	,
cord-001835-0s7ok4uw	2812	5	2014	2014	CD
cord-001835-0s7ok4uw	2812	6	)	)	-RRB-
cord-001835-0s7ok4uw	2813	1	to	to	TO
cord-001835-0s7ok4uw	2813	2	investigate	investigate	VB
cord-001835-0s7ok4uw	2813	3	how	how	WRB
cord-001835-0s7ok4uw	2813	4	the	the	DT
cord-001835-0s7ok4uw	2813	5	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2813	6	of	of	IN
cord-001835-0s7ok4uw	2813	7	related	related	JJ
cord-001835-0s7ok4uw	2813	8	proteins	protein	NNS
cord-001835-0s7ok4uw	2813	9	change	change	VBP
cord-001835-0s7ok4uw	2813	10	when	when	WRB
cord-001835-0s7ok4uw	2813	11	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2813	12	functional	functional	JJ
cord-001835-0s7ok4uw	2813	13	or	or	CC
cord-001835-0s7ok4uw	2813	14	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2813	15	state	state	NN
cord-001835-0s7ok4uw	2813	16	shifts	shift	NNS
cord-001835-0s7ok4uw	2813	17	,	,	,
cord-001835-0s7ok4uw	2813	18	and	and	CC
cord-001835-0s7ok4uw	2813	19	if	if	IN
cord-001835-0s7ok4uw	2813	20	it	-PRON-	PRP
cord-001835-0s7ok4uw	2813	21	is	be	VBZ
cord-001835-0s7ok4uw	2813	22	conserved	conserve	VBN
cord-001835-0s7ok4uw	2813	23	within	within	IN
cord-001835-0s7ok4uw	2813	24	protein	protein	NN
cord-001835-0s7ok4uw	2813	25	families	family	NNS
cord-001835-0s7ok4uw	2813	26	.	.	.
cord-001835-0s7ok4uw	2814	1	In	in	IN
cord-001835-0s7ok4uw	2814	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2814	3	work	work	NN
cord-001835-0s7ok4uw	2814	4	,	,	,
cord-001835-0s7ok4uw	2814	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2814	6	have	have	VBP
cord-001835-0s7ok4uw	2814	7	found	find	VBN
cord-001835-0s7ok4uw	2814	8	that	that	IN
cord-001835-0s7ok4uw	2814	9	proteins	protein	NNS
cord-001835-0s7ok4uw	2814	10	with	with	IN
cord-001835-0s7ok4uw	2814	11	different	different	JJ
cord-001835-0s7ok4uw	2814	12	ligandbinding	ligandbinding	NN
cord-001835-0s7ok4uw	2814	13	states	state	NNS
cord-001835-0s7ok4uw	2814	14	,	,	,
cord-001835-0s7ok4uw	2814	15	as	as	IN
cord-001835-0s7ok4uw	2814	16	in	in	IN
cord-001835-0s7ok4uw	2814	17	adenylate	adenylate	NN
cord-001835-0s7ok4uw	2814	18	kinase	kinase	NN
cord-001835-0s7ok4uw	2814	19	(	(	-LRB-
cord-001835-0s7ok4uw	2814	20	Tiwari	Tiwari	NNP
cord-001835-0s7ok4uw	2814	21	et	et	NNP
cord-001835-0s7ok4uw	2814	22	al	al	NNP
cord-001835-0s7ok4uw	2814	23	.	.	.
cord-001835-0s7ok4uw	2815	1	,	,	,
cord-001835-0s7ok4uw	2815	2	BMC	BMC	NNP
cord-001835-0s7ok4uw	2815	3	Bioinformatics	Bioinformatics	NNP
cord-001835-0s7ok4uw	2815	4	,	,	,
cord-001835-0s7ok4uw	2815	5	2014	2014	CD
cord-001835-0s7ok4uw	2815	6	)	)	-RRB-
cord-001835-0s7ok4uw	2815	7	,	,	,
cord-001835-0s7ok4uw	2815	8	or	or	CC
cord-001835-0s7ok4uw	2815	9	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2815	10	states	state	NNS
cord-001835-0s7ok4uw	2815	11	,	,	,
cord-001835-0s7ok4uw	2815	12	as	as	IN
cord-001835-0s7ok4uw	2815	13	in	in	IN
cord-001835-0s7ok4uw	2815	14	the	the	DT
cord-001835-0s7ok4uw	2815	15	PyrR	PyrR	NNP
cord-001835-0s7ok4uw	2815	16	family	family	NN
cord-001835-0s7ok4uw	2815	17	(	(	-LRB-
cord-001835-0s7ok4uw	2815	18	Perica	Perica	NNP
cord-001835-0s7ok4uw	2815	19	et	et	FW
cord-001835-0s7ok4uw	2815	20	al	al	NNP
cord-001835-0s7ok4uw	2815	21	.	.	NNP
cord-001835-0s7ok4uw	2815	22	,	,	,
cord-001835-0s7ok4uw	2815	23	Science	Science	NNP
cord-001835-0s7ok4uw	2815	24	,	,	,
cord-001835-0s7ok4uw	2815	25	2014	2014	CD
cord-001835-0s7ok4uw	2815	26	)	)	-RRB-
cord-001835-0s7ok4uw	2815	27	,	,	,
cord-001835-0s7ok4uw	2815	28	can	can	MD
cord-001835-0s7ok4uw	2815	29	be	be	VB
cord-001835-0s7ok4uw	2815	30	classified	classify	VBN
cord-001835-0s7ok4uw	2815	31	based	base	VBN
cord-001835-0s7ok4uw	2815	32	on	on	IN
cord-001835-0s7ok4uw	2815	33	the	the	DT
cord-001835-0s7ok4uw	2815	34	global	global	JJ
cord-001835-0s7ok4uw	2815	35	similarity	similarity	NN
cord-001835-0s7ok4uw	2815	36	of	of	IN
cord-001835-0s7ok4uw	2815	37	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2815	38	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	2815	39	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2815	40	.	.	.
cord-001835-0s7ok4uw	2816	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	2816	2	,	,	,
cord-001835-0s7ok4uw	2816	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2816	4	recent	recent	JJ
cord-001835-0s7ok4uw	2816	5	analysis	analysis	NN
cord-001835-0s7ok4uw	2816	6	on	on	IN
cord-001835-0s7ok4uw	2816	7	functionally	functionally	RB
cord-001835-0s7ok4uw	2816	8	distinct	distinct	JJ
cord-001835-0s7ok4uw	2816	9	protein	protein	NN
cord-001835-0s7ok4uw	2816	10	families	family	NNS
cord-001835-0s7ok4uw	2816	11	with	with	IN
cord-001835-0s7ok4uw	2816	12	the	the	DT
cord-001835-0s7ok4uw	2816	13	TIM	TIM	NNP
cord-001835-0s7ok4uw	2816	14	barrel	barrel	NN
cord-001835-0s7ok4uw	2816	15	fold	fold	NNP
cord-001835-0s7ok4uw	2816	16	indicates	indicate	VBZ
cord-001835-0s7ok4uw	2816	17	that	that	IN
cord-001835-0s7ok4uw	2816	18	the	the	DT
cord-001835-0s7ok4uw	2816	19	overall	overall	JJ
cord-001835-0s7ok4uw	2816	20	similarity	similarity	NN
cord-001835-0s7ok4uw	2816	21	in	in	IN
cord-001835-0s7ok4uw	2816	22	shape	shape	NN
cord-001835-0s7ok4uw	2816	23	dictates	dictate	VBZ
cord-001835-0s7ok4uw	2816	24	similarity	similarity	NN
cord-001835-0s7ok4uw	2816	25	in	in	IN
cord-001835-0s7ok4uw	2816	26	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	2816	27	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2816	28	regardless	regardless	RB
cord-001835-0s7ok4uw	2816	29	of	of	IN
cord-001835-0s7ok4uw	2816	30	sequence	sequence	NN
cord-001835-0s7ok4uw	2816	31	and	and	CC
cord-001835-0s7ok4uw	2816	32	functional	functional	JJ
cord-001835-0s7ok4uw	2816	33	conservation	conservation	NN
cord-001835-0s7ok4uw	2816	34	or	or	CC
cord-001835-0s7ok4uw	2816	35	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	2816	36	links	link	NNS
cord-001835-0s7ok4uw	2816	37	.	.	.
cord-001835-0s7ok4uw	2817	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2817	2	suggest	suggest	VBP
cord-001835-0s7ok4uw	2817	3	that	that	IN
cord-001835-0s7ok4uw	2817	4	since	since	IN
cord-001835-0s7ok4uw	2817	5	shape	shape	NN
cord-001835-0s7ok4uw	2817	6	dictates	dictate	VBZ
cord-001835-0s7ok4uw	2817	7	a	a	DT
cord-001835-0s7ok4uw	2817	8	large	large	JJ
cord-001835-0s7ok4uw	2817	9	part	part	NN
cord-001835-0s7ok4uw	2817	10	of	of	IN
cord-001835-0s7ok4uw	2817	11	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	2817	12	similarity	similarity	NN
cord-001835-0s7ok4uw	2817	13	in	in	IN
cord-001835-0s7ok4uw	2817	14	proteins	protein	NNS
cord-001835-0s7ok4uw	2817	15	,	,	,
cord-001835-0s7ok4uw	2817	16	the	the	DT
cord-001835-0s7ok4uw	2817	17	changes	change	NNS
cord-001835-0s7ok4uw	2817	18	in	in	IN
cord-001835-0s7ok4uw	2817	19	local	local	JJ
cord-001835-0s7ok4uw	2817	20	flexibility	flexibility	NN
cord-001835-0s7ok4uw	2817	21	play	play	VB
cord-001835-0s7ok4uw	2817	22	a	a	DT
cord-001835-0s7ok4uw	2817	23	strong	strong	JJ
cord-001835-0s7ok4uw	2817	24	role	role	NN
cord-001835-0s7ok4uw	2817	25	in	in	IN
cord-001835-0s7ok4uw	2817	26	differentiating	differentiate	VBG
cord-001835-0s7ok4uw	2817	27	various	various	JJ
cord-001835-0s7ok4uw	2817	28	functional	functional	JJ
cord-001835-0s7ok4uw	2817	29	states	state	NNS
cord-001835-0s7ok4uw	2817	30	.	.	.
cord-001835-0s7ok4uw	2818	1	Oxygen	oxygen	NN
cord-001835-0s7ok4uw	2818	2	-	-	HYPH
cord-001835-0s7ok4uw	2818	3	Affinity	Affinity	NNP
cord-001835-0s7ok4uw	2818	4	and	and	CC
cord-001835-0s7ok4uw	2818	5	Cooperativity	Cooperativity	NNP
cord-001835-0s7ok4uw	2818	6	of	of	IN
cord-001835-0s7ok4uw	2818	7	Hemoglobin	Hemoglobin	NNP
cord-001835-0s7ok4uw	2818	8	Introduction	introduction	NN
cord-001835-0s7ok4uw	2818	9	:	:	:
cord-001835-0s7ok4uw	2818	10	The	the	DT
cord-001835-0s7ok4uw	2818	11	widely	widely	RB
cord-001835-0s7ok4uw	2818	12	-	-	HYPH
cord-001835-0s7ok4uw	2818	13	held	hold	VBN
cord-001835-0s7ok4uw	2818	14	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2818	15	of	of	IN
cord-001835-0s7ok4uw	2818	16	allostery	allostery	NN
cord-001835-0s7ok4uw	2818	17	of	of	IN
cord-001835-0s7ok4uw	2818	18	Hb	Hb	NNP
cord-001835-0s7ok4uw	2818	19	has	have	VBZ
cord-001835-0s7ok4uw	2818	20	been	be	VBN
cord-001835-0s7ok4uw	2818	21	that	that	IN
cord-001835-0s7ok4uw	2818	22	the	the	DT
cord-001835-0s7ok4uw	2818	23	changes	change	NNS
cord-001835-0s7ok4uw	2818	24	from	from	IN
cord-001835-0s7ok4uw	2818	25	the	the	DT
cord-001835-0s7ok4uw	2818	26	R	r	NN
cord-001835-0s7ok4uw	2818	27	-	-	HYPH
cord-001835-0s7ok4uw	2818	28	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	2818	29	/	/	SYM
cord-001835-0s7ok4uw	2818	30	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	2818	31	structures	structure	NNS
cord-001835-0s7ok4uw	2818	32	of	of	IN
cord-001835-0s7ok4uw	2818	33	oxy	oxy	NN
cord-001835-0s7ok4uw	2818	34	-	-	HYPH
cord-001835-0s7ok4uw	2818	35	Hb	Hb	NNP
cord-001835-0s7ok4uw	2818	36	to	to	IN
cord-001835-0s7ok4uw	2818	37	the	the	DT
cord-001835-0s7ok4uw	2818	38	T	T	NNP
cord-001835-0s7ok4uw	2818	39	-	-	HYPH
cord-001835-0s7ok4uw	2818	40	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	2818	41	/	/	SYM
cord-001835-0s7ok4uw	2818	42	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	2818	43	structures	structure	NNS
cord-001835-0s7ok4uw	2818	44	of	of	IN
cord-001835-0s7ok4uw	2818	45	deoxy	deoxy	NNP
cord-001835-0s7ok4uw	2818	46	-	-	HYPH
cord-001835-0s7ok4uw	2818	47	Hb	Hb	NNP
cord-001835-0s7ok4uw	2818	48	exert	exert	VB
cord-001835-0s7ok4uw	2818	49	certain	certain	JJ
cord-001835-0s7ok4uw	2818	50	constraints	constraint	NNS
cord-001835-0s7ok4uw	2818	51	on	on	IN
cord-001835-0s7ok4uw	2818	52	the	the	DT
cord-001835-0s7ok4uw	2818	53	coordination	coordination	NN
cord-001835-0s7ok4uw	2818	54	structure	structure	NN
cord-001835-0s7ok4uw	2818	55	of	of	IN
cord-001835-0s7ok4uw	2818	56	the	the	DT
cord-001835-0s7ok4uw	2818	57	heme	heme	NN
cord-001835-0s7ok4uw	2818	58	group	group	NN
cord-001835-0s7ok4uw	2818	59	,	,	,
cord-001835-0s7ok4uw	2818	60	leading	lead	VBG
cord-001835-0s7ok4uw	2818	61	to	to	IN
cord-001835-0s7ok4uw	2818	62	a	a	DT
cord-001835-0s7ok4uw	2818	63	lower	low	JJR
cord-001835-0s7ok4uw	2818	64	O2-affinity	o2-affinity	NN
cord-001835-0s7ok4uw	2818	65	of	of	IN
cord-001835-0s7ok4uw	2818	66	the	the	DT
cord-001835-0s7ok4uw	2818	67	hemes	heme	NNS
cord-001835-0s7ok4uw	2818	68	and	and	CC
cord-001835-0s7ok4uw	2818	69	thus	thus	RB
cord-001835-0s7ok4uw	2818	70	that	that	DT
cord-001835-0s7ok4uw	2818	71	of	of	IN
cord-001835-0s7ok4uw	2818	72	Hb	Hb	NNP
cord-001835-0s7ok4uw	2818	73	[	[	-LRB-
cord-001835-0s7ok4uw	2818	74	1	1	CD
cord-001835-0s7ok4uw	2818	75	]	]	-RRB-
cord-001835-0s7ok4uw	2818	76	.	.	.
cord-001835-0s7ok4uw	2819	1	However	however	RB
cord-001835-0s7ok4uw	2819	2	,	,	,
cord-001835-0s7ok4uw	2819	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2819	4	found	find	VBD
cord-001835-0s7ok4uw	2819	5	that	that	IN
cord-001835-0s7ok4uw	2819	6	there	there	EX
cord-001835-0s7ok4uw	2819	7	is	be	VBZ
cord-001835-0s7ok4uw	2819	8	no	no	DT
cord-001835-0s7ok4uw	2819	9	causal	causal	JJ
cord-001835-0s7ok4uw	2819	10	correlation	correlation	NN
cord-001835-0s7ok4uw	2819	11	between	between	IN
cord-001835-0s7ok4uw	2819	12	the	the	DT
cord-001835-0s7ok4uw	2819	13	static	static	JJ
cord-001835-0s7ok4uw	2819	14	T	T	NNP
cord-001835-0s7ok4uw	2819	15	/	/	SYM
cord-001835-0s7ok4uw	2819	16	R	r	NN
cord-001835-0s7ok4uw	2819	17	-	-	HYPH
cord-001835-0s7ok4uw	2819	18	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	2819	19	structures	structure	NNS
cord-001835-0s7ok4uw	2819	20	and	and	CC
cord-001835-0s7ok4uw	2819	21	the	the	DT
cord-001835-0s7ok4uw	2819	22	low	low	JJ
cord-001835-0s7ok4uw	2819	23	/	/	SYM
cord-001835-0s7ok4uw	2819	24	high	high	JJ
cord-001835-0s7ok4uw	2819	25	O2-affinities	o2-affinitie	NNS
cord-001835-0s7ok4uw	2819	26	of	of	IN
cord-001835-0s7ok4uw	2819	27	Hb	Hb	NNP
cord-001835-0s7ok4uw	2819	28	,	,	,
cord-001835-0s7ok4uw	2819	29	respectively	respectively	RB
cord-001835-0s7ok4uw	2819	30	[	[	-LRB-
cord-001835-0s7ok4uw	2819	31	2	2	CD
cord-001835-0s7ok4uw	2819	32	]	]	-RRB-
cord-001835-0s7ok4uw	2819	33	.	.	.
cord-001835-0s7ok4uw	2820	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2820	2	explore	explore	VBP
cord-001835-0s7ok4uw	2820	3	an	an	DT
cord-001835-0s7ok4uw	2820	4	alternative	alternative	JJ
cord-001835-0s7ok4uw	2820	5	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2820	6	of	of	IN
cord-001835-0s7ok4uw	2820	7	the	the	DT
cord-001835-0s7ok4uw	2820	8	regulation	regulation	NN
cord-001835-0s7ok4uw	2820	9	of	of	IN
cord-001835-0s7ok4uw	2820	10	the	the	DT
cord-001835-0s7ok4uw	2820	11	ligand	ligand	NN
cord-001835-0s7ok4uw	2820	12	-	-	HYPH
cord-001835-0s7ok4uw	2820	13	affinity	affinity	NN
cord-001835-0s7ok4uw	2820	14	and	and	CC
cord-001835-0s7ok4uw	2820	15	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	2820	16	in	in	IN
cord-001835-0s7ok4uw	2820	17	Hb	Hb	NNP
cord-001835-0s7ok4uw	2820	18	.	.	.
cord-001835-0s7ok4uw	2821	1	Results	result	NNS
cord-001835-0s7ok4uw	2821	2	and	and	CC
cord-001835-0s7ok4uw	2821	3	Discussion	discussion	NN
cord-001835-0s7ok4uw	2821	4	:	:	:
cord-001835-0s7ok4uw	2822	1	The	the	DT
cord-001835-0s7ok4uw	2822	2	O2-affinities	o2-affinitie	NNS
cord-001835-0s7ok4uw	2822	3	of	of	IN
cord-001835-0s7ok4uw	2822	4	free	free	JJ
cord-001835-0s7ok4uw	2822	5	Fe[II]-protoporphyrin	Fe[II]-protoporphyrin	NNS
cord-001835-0s7ok4uw	2822	6	IX	IX	NNP
cord-001835-0s7ok4uw	2822	7	-	-	HYPH
cord-001835-0s7ok4uw	2822	8	nitrogenous	nitrogenous	JJ
cord-001835-0s7ok4uw	2822	9	base	base	NN
cord-001835-0s7ok4uw	2822	10	complexes	complex	NNS
cord-001835-0s7ok4uw	2822	11	in	in	IN
cord-001835-0s7ok4uw	2822	12	organic	organic	JJ
cord-001835-0s7ok4uw	2822	13	solvents	solvent	NNS
cord-001835-0s7ok4uw	2822	14	are	be	VBP
cord-001835-0s7ok4uw	2822	15	very	very	RB
cord-001835-0s7ok4uw	2822	16	low	low	JJ
cord-001835-0s7ok4uw	2823	1	(	(	-LRB-
cord-001835-0s7ok4uw	2823	2	P50	P50	NNP
cord-001835-0s7ok4uw	2823	3	>	>	XX
cord-001835-0s7ok4uw	2823	4	102	102	CD
cord-001835-0s7ok4uw	2823	5	103	103	CD
cord-001835-0s7ok4uw	2823	6	Torr	Torr	NNP
cord-001835-0s7ok4uw	2823	7	)	)	-RRB-
cord-001835-0s7ok4uw	2823	8	,	,	,
cord-001835-0s7ok4uw	2823	9	whereas	whereas	IN
cord-001835-0s7ok4uw	2823	10	the	the	DT
cord-001835-0s7ok4uw	2823	11	apparent	apparent	JJ
cord-001835-0s7ok4uw	2823	12	O2-affinities	o2-affinitie	NNS
cord-001835-0s7ok4uw	2823	13	of	of	IN
cord-001835-0s7ok4uw	2823	14	these	these	DT
cord-001835-0s7ok4uw	2823	15	metalloporphyrins	metalloporphyrin	NNS
cord-001835-0s7ok4uw	2823	16	,	,	,
cord-001835-0s7ok4uw	2823	17	which	which	WDT
cord-001835-0s7ok4uw	2823	18	are	be	VBP
cord-001835-0s7ok4uw	2823	19	incorporated	incorporate	VBN
cord-001835-0s7ok4uw	2823	20	in	in	IN
cord-001835-0s7ok4uw	2823	21	apo	apo	NNP
cord-001835-0s7ok4uw	2823	22	-	-	HYPH
cord-001835-0s7ok4uw	2823	23	myoglobin	myoglobin	NNP
cord-001835-0s7ok4uw	2823	24	,	,	,
cord-001835-0s7ok4uw	2823	25	apo	apo	NNP
cord-001835-0s7ok4uw	2823	26	-	-	HYPH
cord-001835-0s7ok4uw	2823	27	Hb	Hb	NNP
cord-001835-0s7ok4uw	2823	28	,	,	,
cord-001835-0s7ok4uw	2823	29	serum	serum	NN
cord-001835-0s7ok4uw	2823	30	albumin	albumin	NN
cord-001835-0s7ok4uw	2823	31	,	,	,
cord-001835-0s7ok4uw	2823	32	etc	etc	FW
cord-001835-0s7ok4uw	2823	33	.	.	FW
cord-001835-0s7ok4uw	2823	34	,	,	,
cord-001835-0s7ok4uw	2823	35	increase	increase	VB
cord-001835-0s7ok4uw	2823	36	substantially	substantially	RB
cord-001835-0s7ok4uw	2823	37	to	to	IN
cord-001835-0s7ok4uw	2823	38	P50	P50	NNP
cord-001835-0s7ok4uw	2823	39	<	<	XX
cord-001835-0s7ok4uw	2823	40	10	10	CD
cord-001835-0s7ok4uw	2823	41	-	-	SYM
cord-001835-0s7ok4uw	2823	42	1	1	CD
cord-001835-0s7ok4uw	2823	43	101Torr	101torr	CD
cord-001835-0s7ok4uw	2823	44	,	,	,
cord-001835-0s7ok4uw	2823	45	though	though	IN
cord-001835-0s7ok4uw	2823	46	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2823	47	coordination	coordination	NN
cord-001835-0s7ok4uw	2823	48	structures	structure	NNS
cord-001835-0s7ok4uw	2823	49	are	be	VBP
cord-001835-0s7ok4uw	2823	50	apparently	apparently	RB
cord-001835-0s7ok4uw	2823	51	unchanged	unchanged	JJ
cord-001835-0s7ok4uw	2823	52	[	[	-LRB-
cord-001835-0s7ok4uw	2823	53	3	3	CD
cord-001835-0s7ok4uw	2823	54	]	]	-RRB-
cord-001835-0s7ok4uw	2823	55	.	.	.
cord-001835-0s7ok4uw	2824	1	Such	such	JJ
cord-001835-0s7ok4uw	2824	2	substantial	substantial	JJ
cord-001835-0s7ok4uw	2824	3	increases	increase	NNS
cord-001835-0s7ok4uw	2824	4	in	in	IN
cord-001835-0s7ok4uw	2824	5	the	the	DT
cord-001835-0s7ok4uw	2824	6	apparent	apparent	JJ
cord-001835-0s7ok4uw	2824	7	ligand	ligand	NN
cord-001835-0s7ok4uw	2824	8	-	-	HYPH
cord-001835-0s7ok4uw	2824	9	affinities	affinity	NNS
cord-001835-0s7ok4uw	2824	10	of	of	IN
cord-001835-0s7ok4uw	2824	11	metalloporphyrin	metalloporphyrin	NN
cord-001835-0s7ok4uw	2824	12	-	-	HYPH
cord-001835-0s7ok4uw	2824	13	containing	contain	VBG
cord-001835-0s7ok4uw	2824	14	proteins	protein	NNS
cord-001835-0s7ok4uw	2824	15	are	be	VBP
cord-001835-0s7ok4uw	2824	16	accomplished	accomplish	VBN
cord-001835-0s7ok4uw	2824	17	by	by	IN
cord-001835-0s7ok4uw	2824	18	preventing	prevent	VBG
cord-001835-0s7ok4uw	2824	19	/	/	SYM
cord-001835-0s7ok4uw	2824	20	inteferring	inteferre	VBG
cord-001835-0s7ok4uw	2824	21	with	with	IN
cord-001835-0s7ok4uw	2824	22	the	the	DT
cord-001835-0s7ok4uw	2824	23	dissociation	dissociation	NN
cord-001835-0s7ok4uw	2824	24	of	of	IN
cord-001835-0s7ok4uw	2824	25	the	the	DT
cord-001835-0s7ok4uw	2824	26	ligand	ligand	NN
cord-001835-0s7ok4uw	2824	27	by	by	IN
cord-001835-0s7ok4uw	2824	28	protein	protein	NN
cord-001835-0s7ok4uw	2824	29	matrix	matrix	NN
cord-001835-0s7ok4uw	2824	30	,	,	,
cord-001835-0s7ok4uw	2824	31	since	since	IN
cord-001835-0s7ok4uw	2824	32	the	the	DT
cord-001835-0s7ok4uw	2824	33	interior	interior	NN
cord-001835-0s7ok4uw	2824	34	of	of	IN
cord-001835-0s7ok4uw	2824	35	globin	globin	NN
cord-001835-0s7ok4uw	2824	36	is	be	VBZ
cord-001835-0s7ok4uw	2824	37	nearly	nearly	RB
cord-001835-0s7ok4uw	2824	38	fully	fully	RB
cord-001835-0s7ok4uw	2824	39	packed	pack	VBN
cord-001835-0s7ok4uw	2824	40	by	by	IN
cord-001835-0s7ok4uw	2824	41	protein	protein	NN
cord-001835-0s7ok4uw	2824	42	matrix	matrix	NN
cord-001835-0s7ok4uw	2824	43	.	.	.
cord-001835-0s7ok4uw	2825	1	In	in	IN
cord-001835-0s7ok4uw	2825	2	Hb	Hb	NNP
cord-001835-0s7ok4uw	2825	3	,	,	,
cord-001835-0s7ok4uw	2825	4	the	the	DT
cord-001835-0s7ok4uw	2825	5	dissociation	dissociation	NN
cord-001835-0s7ok4uw	2825	6	process	process	NN
cord-001835-0s7ok4uw	2825	7	of	of	IN
cord-001835-0s7ok4uw	2825	8	the	the	DT
cord-001835-0s7ok4uw	2825	9	ligand	ligand	NN
cord-001835-0s7ok4uw	2825	10	proceeds	proceed	VBZ
cord-001835-0s7ok4uw	2825	11	through	through	IN
cord-001835-0s7ok4uw	2825	12	the	the	DT
cord-001835-0s7ok4uw	2825	13	"	"	``
cord-001835-0s7ok4uw	2825	14	caged	caged	JJ
cord-001835-0s7ok4uw	2825	15	"	"	''
cord-001835-0s7ok4uw	2825	16	state	state	NN
cord-001835-0s7ok4uw	2825	17	[	[	-LRB-
cord-001835-0s7ok4uw	2825	18	4	4	CD
cord-001835-0s7ok4uw	2825	19	]	]	-RRB-
cord-001835-0s7ok4uw	2826	1	[	[	-LRB-
cord-001835-0s7ok4uw	2826	2	5	5	CD
cord-001835-0s7ok4uw	2826	3	]	]	-RRB-
cord-001835-0s7ok4uw	2826	4	[	[	-LRB-
cord-001835-0s7ok4uw	2826	5	6	6	CD
cord-001835-0s7ok4uw	2826	6	]	]	-RRB-
cord-001835-0s7ok4uw	2826	7	,	,	,
cord-001835-0s7ok4uw	2826	8	which	which	WDT
cord-001835-0s7ok4uw	2826	9	can	can	MD
cord-001835-0s7ok4uw	2826	10	be	be	VB
cord-001835-0s7ok4uw	2826	11	produced	produce	VBN
cord-001835-0s7ok4uw	2826	12	by	by	IN
cord-001835-0s7ok4uw	2826	13	cryogenic	cryogenic	JJ
cord-001835-0s7ok4uw	2826	14	photolysis	photolysis	NN
cord-001835-0s7ok4uw	2826	15	of	of	IN
cord-001835-0s7ok4uw	2826	16	the	the	DT
cord-001835-0s7ok4uw	2826	17	ligated	ligate	VBN
cord-001835-0s7ok4uw	2826	18	-	-	HYPH
cord-001835-0s7ok4uw	2826	19	states	state	NNS
cord-001835-0s7ok4uw	2826	20	at	at	IN
cord-001835-0s7ok4uw	2826	21	4.2	4.2	CD
cord-001835-0s7ok4uw	2826	22	K	K	NNP
cord-001835-0s7ok4uw	2826	23	and	and	CC
cord-001835-0s7ok4uw	2826	24	in	in	IN
cord-001835-0s7ok4uw	2826	25	which	which	WDT
cord-001835-0s7ok4uw	2826	26	the	the	DT
cord-001835-0s7ok4uw	2826	27	metal	metal	NN
cord-001835-0s7ok4uw	2826	28	-	-	HYPH
cord-001835-0s7ok4uw	2826	29	ligand	ligand	NN
cord-001835-0s7ok4uw	2826	30	bond	bond	NN
cord-001835-0s7ok4uw	2826	31	is	be	VBZ
cord-001835-0s7ok4uw	2826	32	broken	break	VBN
cord-001835-0s7ok4uw	2826	33	and	and	CC
cord-001835-0s7ok4uw	2826	34	the	the	DT
cord-001835-0s7ok4uw	2826	35	un	un	NNP
cord-001835-0s7ok4uw	2826	36	-	-	HYPH
cord-001835-0s7ok4uw	2826	37	bonded	bond	VBN
cord-001835-0s7ok4uw	2826	38	ligand	ligand	NN
cord-001835-0s7ok4uw	2826	39	is	be	VBZ
cord-001835-0s7ok4uw	2826	40	trapped	trap	VBN
cord-001835-0s7ok4uw	2826	41	near	near	IN
cord-001835-0s7ok4uw	2826	42	the	the	DT
cord-001835-0s7ok4uw	2826	43	bonding	bonding	NN
cord-001835-0s7ok4uw	2826	44	site	site	NN
cord-001835-0s7ok4uw	2826	45	within	within	IN
cord-001835-0s7ok4uw	2826	46	the	the	DT
cord-001835-0s7ok4uw	2826	47	globin	globin	NN
cord-001835-0s7ok4uw	2826	48	moietiy	moietiy	NNP
cord-001835-0s7ok4uw	2826	49	.	.	.
cord-001835-0s7ok4uw	2827	1	This	this	DT
cord-001835-0s7ok4uw	2827	2	"	"	``
cord-001835-0s7ok4uw	2827	3	caged	caged	JJ
cord-001835-0s7ok4uw	2827	4	"	"	''
cord-001835-0s7ok4uw	2827	5	state	state	NN
cord-001835-0s7ok4uw	2827	6	has	have	VBZ
cord-001835-0s7ok4uw	2827	7	spectral	spectral	JJ
cord-001835-0s7ok4uw	2827	8	features	feature	NNS
cord-001835-0s7ok4uw	2827	9	distinct	distinct	JJ
cord-001835-0s7ok4uw	2827	10	from	from	IN
cord-001835-0s7ok4uw	2827	11	those	those	DT
cord-001835-0s7ok4uw	2827	12	of	of	IN
cord-001835-0s7ok4uw	2827	13	either	either	DT
cord-001835-0s7ok4uw	2827	14	deoxyor	deoxyor	JJ
cord-001835-0s7ok4uw	2827	15	ligated	ligate	VBD
cord-001835-0s7ok4uw	2827	16	states	state	NNS
cord-001835-0s7ok4uw	2827	17	of	of	IN
cord-001835-0s7ok4uw	2827	18	the	the	DT
cord-001835-0s7ok4uw	2827	19	respective	respective	JJ
cord-001835-0s7ok4uw	2827	20	hemoproteins	hemoprotein	NNS
cord-001835-0s7ok4uw	2827	21	.	.	.
cord-001835-0s7ok4uw	2828	1	The	the	DT
cord-001835-0s7ok4uw	2828	2	apparent	apparent	JJ
cord-001835-0s7ok4uw	2828	3	ligand	ligand	NN
cord-001835-0s7ok4uw	2828	4	-	-	HYPH
cord-001835-0s7ok4uw	2828	5	affinities	affinity	NNS
cord-001835-0s7ok4uw	2828	6	of	of	IN
cord-001835-0s7ok4uw	2828	7	Hb	Hb	NNP
cord-001835-0s7ok4uw	2828	8	are	be	VBP
cord-001835-0s7ok4uw	2828	9	regulated	regulate	VBN
cord-001835-0s7ok4uw	2828	10	by	by	IN
cord-001835-0s7ok4uw	2828	11	heterotropic	heterotropic	NNP
cord-001835-0s7ok4uw	2828	12	effectors	effector	NNS
cord-001835-0s7ok4uw	2828	13	without	without	IN
cord-001835-0s7ok4uw	2828	14	detectable	detectable	JJ
cord-001835-0s7ok4uw	2828	15	changes	change	NNS
cord-001835-0s7ok4uw	2828	16	in	in	IN
cord-001835-0s7ok4uw	2828	17	either	either	DT
cord-001835-0s7ok4uw	2828	18	static	static	JJ
cord-001835-0s7ok4uw	2828	19	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	2828	20	/	/	SYM
cord-001835-0s7ok4uw	2828	21	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	2828	22	structures	structure	NNS
cord-001835-0s7ok4uw	2828	23	of	of	IN
cord-001835-0s7ok4uw	2828	24	the	the	DT
cord-001835-0s7ok4uw	2828	25	globin	globin	NN
cord-001835-0s7ok4uw	2828	26	moiety	moiety	NN
cord-001835-0s7ok4uw	2828	27	or	or	CC
cord-001835-0s7ok4uw	2828	28	the	the	DT
cord-001835-0s7ok4uw	2828	29	coordination	coordination	NN
cord-001835-0s7ok4uw	2828	30	/	/	SYM
cord-001835-0s7ok4uw	2828	31	electronic	electronic	JJ
cord-001835-0s7ok4uw	2828	32	structures	structure	NNS
cord-001835-0s7ok4uw	2828	33	of	of	IN
cord-001835-0s7ok4uw	2828	34	the	the	DT
cord-001835-0s7ok4uw	2828	35	metalloporphyrin	metalloporphyrin	NNP
cord-001835-0s7ok4uw	2828	36	moiety	moiety	NNP
cord-001835-0s7ok4uw	2828	37	and	and	CC
cord-001835-0s7ok4uw	2828	38	thus	thus	RB
cord-001835-0s7ok4uw	2828	39	the	the	DT
cord-001835-0s7ok4uw	2828	40	ligand	ligand	NN
cord-001835-0s7ok4uw	2828	41	-	-	HYPH
cord-001835-0s7ok4uw	2828	42	affinity	affinity	NN
cord-001835-0s7ok4uw	2828	43	of	of	IN
cord-001835-0s7ok4uw	2828	44	the	the	DT
cord-001835-0s7ok4uw	2828	45	metalloporphyrins	metalloporphyrin	NNS
cord-001835-0s7ok4uw	2828	46	themselves	-PRON-	PRP
cord-001835-0s7ok4uw	2828	47	[	[	-LRB-
cord-001835-0s7ok4uw	2828	48	7	7	CD
cord-001835-0s7ok4uw	2828	49	]	]	-RRB-
cord-001835-0s7ok4uw	2828	50	[	[	-LRB-
cord-001835-0s7ok4uw	2828	51	8	8	CD
cord-001835-0s7ok4uw	2828	52	]	]	-RRB-
cord-001835-0s7ok4uw	2828	53	[	[	-LRB-
cord-001835-0s7ok4uw	2828	54	9	9	CD
cord-001835-0s7ok4uw	2828	55	]	]	-RRB-
cord-001835-0s7ok4uw	2828	56	.	.	.
cord-001835-0s7ok4uw	2829	1	The	the	DT
cord-001835-0s7ok4uw	2829	2	reduction	reduction	NN
cord-001835-0s7ok4uw	2829	3	of	of	IN
cord-001835-0s7ok4uw	2829	4	the	the	DT
cord-001835-0s7ok4uw	2829	5	apparent	apparent	JJ
cord-001835-0s7ok4uw	2829	6	ligand	ligand	NN
cord-001835-0s7ok4uw	2829	7	-	-	HYPH
cord-001835-0s7ok4uw	2829	8	affinities	affinity	NNS
cord-001835-0s7ok4uw	2829	9	of	of	IN
cord-001835-0s7ok4uw	2829	10	Hb	Hb	NNP
cord-001835-0s7ok4uw	2829	11	may	may	MD
cord-001835-0s7ok4uw	2829	12	be	be	VB
cord-001835-0s7ok4uw	2829	13	caused	cause	VBN
cord-001835-0s7ok4uw	2829	14	by	by	IN
cord-001835-0s7ok4uw	2829	15	increases	increase	NNS
cord-001835-0s7ok4uw	2829	16	in	in	IN
cord-001835-0s7ok4uw	2829	17	the	the	DT
cord-001835-0s7ok4uw	2829	18	migration	migration	NN
cord-001835-0s7ok4uw	2829	19	rate	rate	NN
cord-001835-0s7ok4uw	2829	20	of	of	IN
cord-001835-0s7ok4uw	2829	21	ligands	ligand	NNS
cord-001835-0s7ok4uw	2829	22	through	through	IN
cord-001835-0s7ok4uw	2829	23	globin	globin	NN
cord-001835-0s7ok4uw	2829	24	matrix	matrix	NN
cord-001835-0s7ok4uw	2829	25	from	from	IN
cord-001835-0s7ok4uw	2829	26	the	the	DT
cord-001835-0s7ok4uw	2829	27	"	"	``
cord-001835-0s7ok4uw	2829	28	caged	caged	JJ
cord-001835-0s7ok4uw	2829	29	"	"	''
cord-001835-0s7ok4uw	2829	30	state	state	NN
cord-001835-0s7ok4uw	2829	31	to	to	IN
cord-001835-0s7ok4uw	2829	32	solvent	solvent	NN
cord-001835-0s7ok4uw	2829	33	,	,	,
cord-001835-0s7ok4uw	2829	34	resulting	result	VBG
cord-001835-0s7ok4uw	2829	35	from	from	IN
cord-001835-0s7ok4uw	2829	36	the	the	DT
cord-001835-0s7ok4uw	2829	37	effector	effector	NN
cord-001835-0s7ok4uw	2829	38	-	-	HYPH
cord-001835-0s7ok4uw	2829	39	linked	link	VBN
cord-001835-0s7ok4uw	2829	40	,	,	,
cord-001835-0s7ok4uw	2829	41	enhanced	enhance	VBN
cord-001835-0s7ok4uw	2829	42	high	high	JJ
cord-001835-0s7ok4uw	2829	43	-	-	HYPH
cord-001835-0s7ok4uw	2829	44	frequency	frequency	NN
cord-001835-0s7ok4uw	2829	45	thermal	thermal	JJ
cord-001835-0s7ok4uw	2829	46	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	2829	47	which	which	WDT
cord-001835-0s7ok4uw	2829	48	increase	increase	VBP
cord-001835-0s7ok4uw	2829	49	the	the	DT
cord-001835-0s7ok4uw	2829	50	transparency	transparency	NN
cord-001835-0s7ok4uw	2829	51	of	of	IN
cord-001835-0s7ok4uw	2829	52	the	the	DT
cord-001835-0s7ok4uw	2829	53	globin	globin	NN
cord-001835-0s7ok4uw	2829	54	matrix	matrix	NN
cord-001835-0s7ok4uw	2829	55	toward	toward	IN
cord-001835-0s7ok4uw	2829	56	small	small	JJ
cord-001835-0s7ok4uw	2829	57	diatomic	diatomic	JJ
cord-001835-0s7ok4uw	2829	58	ligands	ligand	NNS
cord-001835-0s7ok4uw	2829	59	[	[	-LRB-
cord-001835-0s7ok4uw	2829	60	7	7	CD
cord-001835-0s7ok4uw	2829	61	]	]	-RRB-
cord-001835-0s7ok4uw	2830	1	[	[	-LRB-
cord-001835-0s7ok4uw	2830	2	8	8	CD
cord-001835-0s7ok4uw	2830	3	]	]	-RRB-
cord-001835-0s7ok4uw	2830	4	[	[	-LRB-
cord-001835-0s7ok4uw	2830	5	9	9	CD
cord-001835-0s7ok4uw	2830	6	]	]	-RRB-
cord-001835-0s7ok4uw	2830	7	.	.	.
cord-001835-0s7ok4uw	2831	1	Conclusion	conclusion	NN
cord-001835-0s7ok4uw	2831	2	:	:	:
cord-001835-0s7ok4uw	2832	1	The	the	DT
cord-001835-0s7ok4uw	2832	2	ligand	ligand	NN
cord-001835-0s7ok4uw	2832	3	-	-	HYPH
cord-001835-0s7ok4uw	2832	4	affinity	affinity	NN
cord-001835-0s7ok4uw	2832	5	of	of	IN
cord-001835-0s7ok4uw	2832	6	Hb	Hb	NNP
cord-001835-0s7ok4uw	2832	7	is	be	VBZ
cord-001835-0s7ok4uw	2832	8	regulated	regulate	VBN
cord-001835-0s7ok4uw	2832	9	through	through	IN
cord-001835-0s7ok4uw	2832	10	protein	protein	NN
cord-001835-0s7ok4uw	2832	11	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2832	12	by	by	IN
cord-001835-0s7ok4uw	2832	13	heterotropic	heterotropic	NNP
cord-001835-0s7ok4uw	2832	14	effectors	effector	NNS
cord-001835-0s7ok4uw	2832	15	,	,	,
cord-001835-0s7ok4uw	2832	16	rather	rather	RB
cord-001835-0s7ok4uw	2832	17	than	than	IN
cord-001835-0s7ok4uw	2832	18	static	static	JJ
cord-001835-0s7ok4uw	2832	19	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	2832	20	/	/	SYM
cord-001835-0s7ok4uw	2832	21	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	2832	22	structural	structural	JJ
cord-001835-0s7ok4uw	2832	23	changes	change	NNS
cord-001835-0s7ok4uw	2832	24	.	.	.
cord-001835-0s7ok4uw	2833	1	Thus	thus	RB
cord-001835-0s7ok4uw	2833	2	,	,	,
cord-001835-0s7ok4uw	2833	3	the	the	DT
cord-001835-0s7ok4uw	2833	4	"	"	``
cord-001835-0s7ok4uw	2833	5	caged	caged	JJ
cord-001835-0s7ok4uw	2833	6	"	"	''
cord-001835-0s7ok4uw	2833	7	state	state	NN
cord-001835-0s7ok4uw	2833	8	of	of	IN
cord-001835-0s7ok4uw	2833	9	Hb	Hb	NNP
cord-001835-0s7ok4uw	2833	10	acts	act	VBZ
cord-001835-0s7ok4uw	2833	11	as	as	IN
cord-001835-0s7ok4uw	2833	12	a	a	DT
cord-001835-0s7ok4uw	2833	13	critical	critical	JJ
cord-001835-0s7ok4uw	2833	14	transition	transition	NN
cord-001835-0s7ok4uw	2833	15	state	state	NN
cord-001835-0s7ok4uw	2833	16	in	in	IN
cord-001835-0s7ok4uw	2833	17	regulation	regulation	NN
cord-001835-0s7ok4uw	2833	18	of	of	IN
cord-001835-0s7ok4uw	2833	19	the	the	DT
cord-001835-0s7ok4uw	2833	20	affinity	affinity	NN
cord-001835-0s7ok4uw	2833	21	for	for	IN
cord-001835-0s7ok4uw	2833	22	small	small	JJ
cord-001835-0s7ok4uw	2833	23	diatomic	diatomic	JJ
cord-001835-0s7ok4uw	2833	24	ligands	ligand	NNS
cord-001835-0s7ok4uw	2833	25	in	in	IN
cord-001835-0s7ok4uw	2833	26	Hb	Hb	NNP
cord-001835-0s7ok4uw	2833	27	[	[	-LRB-
cord-001835-0s7ok4uw	2833	28	9	9	CD
cord-001835-0s7ok4uw	2833	29	]	]	-RRB-
cord-001835-0s7ok4uw	2833	30	.	.	.
cord-001835-0s7ok4uw	2833	31	 	 	_SP
cord-001835-0s7ok4uw	2834	1	The	the	DT
cord-001835-0s7ok4uw	2834	2	role	role	NN
cord-001835-0s7ok4uw	2834	3	of	of	IN
cord-001835-0s7ok4uw	2834	4	metal	metal	NN
cord-001835-0s7ok4uw	2834	5	ions	ion	NNS
cord-001835-0s7ok4uw	2834	6	in	in	IN
cord-001835-0s7ok4uw	2834	7	the	the	DT
cord-001835-0s7ok4uw	2834	8	regulation	regulation	NN
cord-001835-0s7ok4uw	2834	9	of	of	IN
cord-001835-0s7ok4uw	2834	10	life	life	NN
cord-001835-0s7ok4uw	2834	11	processes	process	NNS
cord-001835-0s7ok4uw	2834	12	is	be	VBZ
cord-001835-0s7ok4uw	2834	13	extremely	extremely	RB
cord-001835-0s7ok4uw	2834	14	important	important	JJ
cord-001835-0s7ok4uw	2834	15	.	.	.
cord-001835-0s7ok4uw	2835	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	2835	2	act	act	VBP
cord-001835-0s7ok4uw	2835	3	as	as	IN
cord-001835-0s7ok4uw	2835	4	signal	signal	NN
cord-001835-0s7ok4uw	2835	5	transducers	transducer	NNS
cord-001835-0s7ok4uw	2835	6	,	,	,
cord-001835-0s7ok4uw	2835	7	protein	protein	NN
cord-001835-0s7ok4uw	2835	8	configuration	configuration	NN
cord-001835-0s7ok4uw	2835	9	stabilizers	stabilizer	NNS
cord-001835-0s7ok4uw	2835	10	,	,	,
cord-001835-0s7ok4uw	2835	11	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	2835	12	cofactors	cofactor	NNS
cord-001835-0s7ok4uw	2835	13	,	,	,
cord-001835-0s7ok4uw	2835	14	oxygen	oxygen	NN
cord-001835-0s7ok4uw	2835	15	transport	transport	NN
cord-001835-0s7ok4uw	2835	16	supporters	supporter	NNS
cord-001835-0s7ok4uw	2835	17	and	and	CC
cord-001835-0s7ok4uw	2835	18	many	many	JJ
cord-001835-0s7ok4uw	2835	19	others	other	NNS
cord-001835-0s7ok4uw	2835	20	.	.	.
cord-001835-0s7ok4uw	2836	1	For	for	IN
cord-001835-0s7ok4uw	2836	2	example	example	NN
cord-001835-0s7ok4uw	2836	3	,	,	,
cord-001835-0s7ok4uw	2836	4	subtle	subtle	JJ
cord-001835-0s7ok4uw	2836	5	perturbations	perturbation	NNS
cord-001835-0s7ok4uw	2836	6	in	in	IN
cord-001835-0s7ok4uw	2836	7	calcium	calcium	NN
cord-001835-0s7ok4uw	2836	8	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	2836	9	may	may	MD
cord-001835-0s7ok4uw	2836	10	lead	lead	VB
cord-001835-0s7ok4uw	2836	11	to	to	IN
cord-001835-0s7ok4uw	2836	12	mental	mental	JJ
cord-001835-0s7ok4uw	2836	13	disabilities	disability	NNS
cord-001835-0s7ok4uw	2836	14	and	and	CC
cord-001835-0s7ok4uw	2836	15	are	be	VBP
cord-001835-0s7ok4uw	2836	16	linked	link	VBN
cord-001835-0s7ok4uw	2836	17	to	to	IN
cord-001835-0s7ok4uw	2836	18	diseases	disease	NNS
cord-001835-0s7ok4uw	2836	19	such	such	JJ
cord-001835-0s7ok4uw	2836	20	as	as	IN
cord-001835-0s7ok4uw	2836	21	Autism	Autism	NNP
cord-001835-0s7ok4uw	2836	22	Spectrum	Spectrum	NNP
cord-001835-0s7ok4uw	2836	23	Disorders	Disorders	NNPS
cord-001835-0s7ok4uw	2836	24	(	(	-LRB-
cord-001835-0s7ok4uw	2836	25	ASD	ASD	NNP
cord-001835-0s7ok4uw	2836	26	)	)	-RRB-
cord-001835-0s7ok4uw	2836	27	.	.	.
cord-001835-0s7ok4uw	2837	1	In	in	IN
cord-001835-0s7ok4uw	2837	2	this	this	DT
cord-001835-0s7ok4uw	2837	3	study	study	NN
cord-001835-0s7ok4uw	2837	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	2837	5	focus	focus	VBP
cord-001835-0s7ok4uw	2837	6	on	on	IN
cord-001835-0s7ok4uw	2837	7	complex	complex	JJ
cord-001835-0s7ok4uw	2837	8	protein	protein	NN
cord-001835-0s7ok4uw	2837	9	systems	system	NNS
cord-001835-0s7ok4uw	2837	10	,	,	,
cord-001835-0s7ok4uw	2837	11	mainly	mainly	RB
cord-001835-0s7ok4uw	2837	12	those	those	DT
cord-001835-0s7ok4uw	2837	13	present	present	JJ
cord-001835-0s7ok4uw	2837	14	in	in	IN
cord-001835-0s7ok4uw	2837	15	the	the	DT
cord-001835-0s7ok4uw	2837	16	brain	brain	NN
cord-001835-0s7ok4uw	2837	17	.	.	.
cord-001835-0s7ok4uw	2838	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2838	2	search	search	VBP
cord-001835-0s7ok4uw	2838	3	for	for	IN
cord-001835-0s7ok4uw	2838	4	dimers	dimer	NNS
cord-001835-0s7ok4uw	2838	5	mediated	mediate	VBN
cord-001835-0s7ok4uw	2838	6	by	by	IN
cord-001835-0s7ok4uw	2838	7	the	the	DT
cord-001835-0s7ok4uw	2838	8	presence	presence	NN
cord-001835-0s7ok4uw	2838	9	of	of	IN
cord-001835-0s7ok4uw	2838	10	metal	metal	NN
cord-001835-0s7ok4uw	2838	11	ions	ion	NNS
cord-001835-0s7ok4uw	2838	12	,	,	,
cord-001835-0s7ok4uw	2838	13	and	and	CC
cord-001835-0s7ok4uw	2838	14	determine	determine	VB
cord-001835-0s7ok4uw	2838	15	the	the	DT
cord-001835-0s7ok4uw	2838	16	impact	impact	NN
cord-001835-0s7ok4uw	2838	17	of	of	IN
cord-001835-0s7ok4uw	2838	18	the	the	DT
cord-001835-0s7ok4uw	2838	19	presence	presence	NN
cord-001835-0s7ok4uw	2838	20	or	or	CC
cord-001835-0s7ok4uw	2838	21	absence	absence	NN
cord-001835-0s7ok4uw	2838	22	of	of	IN
cord-001835-0s7ok4uw	2838	23	the	the	DT
cord-001835-0s7ok4uw	2838	24	latter	latter	JJ
cord-001835-0s7ok4uw	2838	25	on	on	IN
cord-001835-0s7ok4uw	2838	26	the	the	DT
cord-001835-0s7ok4uw	2838	27	structure	structure	NN
cord-001835-0s7ok4uw	2838	28	and	and	CC
cord-001835-0s7ok4uw	2838	29	energetic	energetic	JJ
cord-001835-0s7ok4uw	2838	30	properties	property	NNS
cord-001835-0s7ok4uw	2838	31	of	of	IN
cord-001835-0s7ok4uw	2838	32	the	the	DT
cord-001835-0s7ok4uw	2838	33	complex	complex	NN
cord-001835-0s7ok4uw	2838	34	in	in	IN
cord-001835-0s7ok4uw	2838	35	the	the	DT
cord-001835-0s7ok4uw	2838	36	protein	protein	NN
cord-001835-0s7ok4uw	2838	37	-	-	HYPH
cord-001835-0s7ok4uw	2838	38	protein	protein	NN
cord-001835-0s7ok4uw	2838	39	interface	interface	NN
cord-001835-0s7ok4uw	2838	40	.	.	.
cord-001835-0s7ok4uw	2839	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2839	2	investigate	investigate	VBP
cord-001835-0s7ok4uw	2839	3	ions	ion	NNS
cord-001835-0s7ok4uw	2839	4	'	'	POS
cord-001835-0s7ok4uw	2839	5	influence	influence	NN
cord-001835-0s7ok4uw	2839	6	on	on	IN
cord-001835-0s7ok4uw	2839	7	the	the	DT
cord-001835-0s7ok4uw	2839	8	interface	interface	NN
cord-001835-0s7ok4uw	2839	9	stability	stability	NN
cord-001835-0s7ok4uw	2839	10	using	use	VBG
cord-001835-0s7ok4uw	2839	11	classic	classic	JJ
cord-001835-0s7ok4uw	2839	12	molecular	molecular	JJ
cord-001835-0s7ok4uw	2839	13	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2839	14	methods	method	NNS
cord-001835-0s7ok4uw	2839	15	(	(	-LRB-
cord-001835-0s7ok4uw	2839	16	MD	MD	NNP
cord-001835-0s7ok4uw	2839	17	)	)	-RRB-
cord-001835-0s7ok4uw	2839	18	,	,	,
cord-001835-0s7ok4uw	2839	19	including	include	VBG
cord-001835-0s7ok4uw	2839	20	Steered	steer	VBN
cord-001835-0s7ok4uw	2839	21	MD	MD	NNP
cord-001835-0s7ok4uw	2839	22	.	.	.
cord-001835-0s7ok4uw	2840	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	2840	2	,	,	,
cord-001835-0s7ok4uw	2840	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2840	4	apply	apply	VBP
cord-001835-0s7ok4uw	2840	5	a	a	DT
cord-001835-0s7ok4uw	2840	6	novel	novel	JJ
cord-001835-0s7ok4uw	2840	7	suite	suite	NN
cord-001835-0s7ok4uw	2840	8	of	of	IN
cord-001835-0s7ok4uw	2840	9	enhanced	enhance	VBN
cord-001835-0s7ok4uw	2840	10	MD	MD	NNP
cord-001835-0s7ok4uw	2840	11	-	-	HYPH
cord-001835-0s7ok4uw	2840	12	based	base	VBN
cord-001835-0s7ok4uw	2840	13	methods	method	NNS
cord-001835-0s7ok4uw	2840	14	recently	recently	RB
cord-001835-0s7ok4uw	2840	15	developed	develop	VBN
cord-001835-0s7ok4uw	2840	16	by	by	IN
cord-001835-0s7ok4uw	2840	17	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2840	18	team	team	NN
cord-001835-0s7ok4uw	2840	19	(	(	-LRB-
cord-001835-0s7ok4uw	2840	20	Rydzewski	Rydzewski	NNP
cord-001835-0s7ok4uw	2840	21	&	&	CC
cord-001835-0s7ok4uw	2840	22	Nowak	Nowak	NNP
cord-001835-0s7ok4uw	2840	23	)	)	-RRB-
cord-001835-0s7ok4uw	2840	24	to	to	TO
cord-001835-0s7ok4uw	2840	25	explore	explore	VB
cord-001835-0s7ok4uw	2840	26	ion	ion	NN
cord-001835-0s7ok4uw	2840	27	diffusion	diffusion	NN
cord-001835-0s7ok4uw	2840	28	pathways	pathway	NNS
cord-001835-0s7ok4uw	2840	29	in	in	IN
cord-001835-0s7ok4uw	2840	30	protein	protein	NN
cord-001835-0s7ok4uw	2840	31	fragments	fragment	NNS
cord-001835-0s7ok4uw	2840	32	of	of	IN
cord-001835-0s7ok4uw	2840	33	the	the	DT
cord-001835-0s7ok4uw	2840	34	synapses	synapsis	NNS
cord-001835-0s7ok4uw	2840	35	.	.	.
cord-001835-0s7ok4uw	2841	1	Finally	finally	RB
cord-001835-0s7ok4uw	2841	2	,	,	,
cord-001835-0s7ok4uw	2841	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2841	4	describe	describe	VBP
cord-001835-0s7ok4uw	2841	5	specific	specific	JJ
cord-001835-0s7ok4uw	2841	6	inter	inter	JJ
cord-001835-0s7ok4uw	2841	7	-	-	JJ
cord-001835-0s7ok4uw	2841	8	protein	protein	JJ
cord-001835-0s7ok4uw	2841	9	ion	ion	NN
cord-001835-0s7ok4uw	2841	10	binding	bind	VBG
cord-001835-0s7ok4uw	2841	11	motifs	motif	NNS
cord-001835-0s7ok4uw	2841	12	with	with	IN
cord-001835-0s7ok4uw	2841	13	the	the	DT
cord-001835-0s7ok4uw	2841	14	most	most	RBS
cord-001835-0s7ok4uw	2841	15	important	important	JJ
cord-001835-0s7ok4uw	2841	16	interactions	interaction	NNS
cord-001835-0s7ok4uw	2841	17	,	,	,
cord-001835-0s7ok4uw	2841	18	collating	collate	VBG
cord-001835-0s7ok4uw	2841	19	them	-PRON-	PRP
cord-001835-0s7ok4uw	2841	20	with	with	IN
cord-001835-0s7ok4uw	2841	21	various	various	JJ
cord-001835-0s7ok4uw	2841	22	structures	structure	NNS
cord-001835-0s7ok4uw	2841	23	deposited	deposit	VBN
cord-001835-0s7ok4uw	2841	24	in	in	IN
cord-001835-0s7ok4uw	2841	25	the	the	DT
cord-001835-0s7ok4uw	2841	26	Protein	Protein	NNP
cord-001835-0s7ok4uw	2841	27	Data	Data	NNP
cord-001835-0s7ok4uw	2841	28	Bank	Bank	NNP
cord-001835-0s7ok4uw	2841	29	[	[	-LRB-
cord-001835-0s7ok4uw	2841	30	1	1	CD
cord-001835-0s7ok4uw	2841	31	]	]	-RRB-
cord-001835-0s7ok4uw	2841	32	.	.	.
cord-001835-0s7ok4uw	2842	1	The	the	DT
cord-001835-0s7ok4uw	2842	2	binding	binding	NN
cord-001835-0s7ok4uw	2842	3	of	of	IN
cord-001835-0s7ok4uw	2842	4	integrins	integrin	NNS
cord-001835-0s7ok4uw	2842	5	to	to	IN
cord-001835-0s7ok4uw	2842	6	collagen	collagen	NN
cord-001835-0s7ok4uw	2842	7	plays	play	VBZ
cord-001835-0s7ok4uw	2842	8	a	a	DT
cord-001835-0s7ok4uw	2842	9	critical	critical	JJ
cord-001835-0s7ok4uw	2842	10	role	role	NN
cord-001835-0s7ok4uw	2842	11	in	in	IN
cord-001835-0s7ok4uw	2842	12	numerous	numerous	JJ
cord-001835-0s7ok4uw	2842	13	cellular	cellular	JJ
cord-001835-0s7ok4uw	2842	14	adhesion	adhesion	NN
cord-001835-0s7ok4uw	2842	15	processes	process	NNS
cord-001835-0s7ok4uw	2842	16	including	include	VBG
cord-001835-0s7ok4uw	2842	17	platelet	platelet	NN
cord-001835-0s7ok4uw	2842	18	activation	activation	NN
cord-001835-0s7ok4uw	2842	19	and	and	CC
cord-001835-0s7ok4uw	2842	20	aggregation	aggregation	NN
cord-001835-0s7ok4uw	2842	21	,	,	,
cord-001835-0s7ok4uw	2842	22	a	a	DT
cord-001835-0s7ok4uw	2842	23	key	key	JJ
cord-001835-0s7ok4uw	2842	24	process	process	NN
cord-001835-0s7ok4uw	2842	25	in	in	IN
cord-001835-0s7ok4uw	2842	26	clot	clot	NN
cord-001835-0s7ok4uw	2842	27	formation	formation	NN
cord-001835-0s7ok4uw	2842	28	.	.	.
cord-001835-0s7ok4uw	2843	1	Collagen	collagen	NN
cord-001835-0s7ok4uw	2843	2	is	be	VBZ
cord-001835-0s7ok4uw	2843	3	an	an	DT
cord-001835-0s7ok4uw	2843	4	unusually	unusually	RB
cord-001835-0s7ok4uw	2843	5	shaped	shaped	JJ
cord-001835-0s7ok4uw	2843	6	ligand	ligand	NN
cord-001835-0s7ok4uw	2843	7	,	,	,
cord-001835-0s7ok4uw	2843	8	and	and	CC
cord-001835-0s7ok4uw	2843	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2843	10	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2843	11	of	of	IN
cord-001835-0s7ok4uw	2843	12	recognition	recognition	NN
cord-001835-0s7ok4uw	2843	13	and	and	CC
cord-001835-0s7ok4uw	2843	14	role	role	NN
cord-001835-0s7ok4uw	2843	15	in	in	IN
cord-001835-0s7ok4uw	2843	16	selectivity	selectivity	NN
cord-001835-0s7ok4uw	2843	17	and	and	CC
cord-001835-0s7ok4uw	2843	18	affinity	affinity	NN
cord-001835-0s7ok4uw	2843	19	are	be	VBP
cord-001835-0s7ok4uw	2843	20	unique	unique	JJ
cord-001835-0s7ok4uw	2843	21	,	,	,
cord-001835-0s7ok4uw	2843	22	and	and	CC
cord-001835-0s7ok4uw	2843	23	at	at	IN
cord-001835-0s7ok4uw	2843	24	this	this	DT
cord-001835-0s7ok4uw	2843	25	stage	stage	NN
cord-001835-0s7ok4uw	2843	26	not	not	RB
cord-001835-0s7ok4uw	2843	27	well	well	RB
cord-001835-0s7ok4uw	2843	28	understood	understand	VBN
cord-001835-0s7ok4uw	2843	29	.	.	.
cord-001835-0s7ok4uw	2844	1	The	the	DT
cord-001835-0s7ok4uw	2844	2	I	i	NN
cord-001835-0s7ok4uw	2844	3	-	-	HYPH
cord-001835-0s7ok4uw	2844	4	domain	domain	NN
cord-001835-0s7ok4uw	2844	5	of	of	IN
cord-001835-0s7ok4uw	2844	6	the	the	DT
cord-001835-0s7ok4uw	2844	7	integrin	integrin	NN
cord-001835-0s7ok4uw	2844	8	protein	protein	NN
cord-001835-0s7ok4uw	2844	9	binds	bind	VBZ
cord-001835-0s7ok4uw	2844	10	to	to	IN
cord-001835-0s7ok4uw	2844	11	collagen	collagen	NN
cord-001835-0s7ok4uw	2844	12	specifically	specifically	RB
cord-001835-0s7ok4uw	2844	13	at	at	IN
cord-001835-0s7ok4uw	2844	14	multiple	multiple	JJ
cord-001835-0s7ok4uw	2844	15	sites	site	NNS
cord-001835-0s7ok4uw	2844	16	with	with	IN
cord-001835-0s7ok4uw	2844	17	variable	variable	JJ
cord-001835-0s7ok4uw	2844	18	affinities	affinity	NNS
cord-001835-0s7ok4uw	2844	19	,	,	,
cord-001835-0s7ok4uw	2844	20	however	however	RB
cord-001835-0s7ok4uw	2844	21	the	the	DT
cord-001835-0s7ok4uw	2844	22	molecular	molecular	JJ
cord-001835-0s7ok4uw	2844	23	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2844	24	of	of	IN
cord-001835-0s7ok4uw	2844	25	integrin	integrin	NN
cord-001835-0s7ok4uw	2845	1	I	i	NN
cord-001835-0s7ok4uw	2845	2	-	-	HYPH
cord-001835-0s7ok4uw	2845	3	domain	domain	NN
cord-001835-0s7ok4uw	2845	4	(	(	-LRB-
cord-001835-0s7ok4uw	2845	5	aI	ai	NN
cord-001835-0s7ok4uw	2845	6	)	)	-RRB-
cord-001835-0s7ok4uw	2845	7	regulation	regulation	NN
cord-001835-0s7ok4uw	2845	8	remains	remain	VBZ
cord-001835-0s7ok4uw	2845	9	unknown	unknown	JJ
cord-001835-0s7ok4uw	2845	10	.	.	.
cord-001835-0s7ok4uw	2846	1	Using	use	VBG
cord-001835-0s7ok4uw	2846	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	2846	3	,	,	,
cord-001835-0s7ok4uw	2846	4	along	along	IN
cord-001835-0s7ok4uw	2846	5	with	with	IN
cord-001835-0s7ok4uw	2846	6	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	2846	7	titration	titration	NN
cord-001835-0s7ok4uw	2846	8	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	2846	9	,	,	,
cord-001835-0s7ok4uw	2846	10	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	2846	11	,	,	,
cord-001835-0s7ok4uw	2846	12	and	and	CC
cord-001835-0s7ok4uw	2846	13	binding	bind	VBG
cord-001835-0s7ok4uw	2846	14	assays	assay	NNS
cord-001835-0s7ok4uw	2846	15	we	-PRON-	PRP
cord-001835-0s7ok4uw	2846	16	are	be	VBP
cord-001835-0s7ok4uw	2846	17	developing	develop	VBG
cord-001835-0s7ok4uw	2846	18	a	a	DT
cord-001835-0s7ok4uw	2846	19	novel	novel	JJ
cord-001835-0s7ok4uw	2846	20	integrated	integrate	VBN
cord-001835-0s7ok4uw	2846	21	picture	picture	NN
cord-001835-0s7ok4uw	2846	22	of	of	IN
cord-001835-0s7ok4uw	2846	23	the	the	DT
cord-001835-0s7ok4uw	2846	24	full	full	JJ
cord-001835-0s7ok4uw	2846	25	recognition	recognition	NN
cord-001835-0s7ok4uw	2846	26	process	process	NN
cord-001835-0s7ok4uw	2846	27	of	of	IN
cord-001835-0s7ok4uw	2846	28	the	the	DT
cord-001835-0s7ok4uw	2846	29	integrin	integrin	NN
cord-001835-0s7ok4uw	2846	30	a1I	a1i	NN
cord-001835-0s7ok4uw	2846	31	binding	bind	VBG
cord-001835-0s7ok4uw	2846	32	to	to	IN
cord-001835-0s7ok4uw	2846	33	collagen	collagen	NN
cord-001835-0s7ok4uw	2846	34	.	.	.
cord-001835-0s7ok4uw	2847	1	The	the	DT
cord-001835-0s7ok4uw	2847	2	adhesion	adhesion	NN
cord-001835-0s7ok4uw	2847	3	of	of	IN
cord-001835-0s7ok4uw	2847	4	the	the	DT
cord-001835-0s7ok4uw	2847	5	a1b1	a1b1	NNP
cord-001835-0s7ok4uw	2847	6	integrin	integrin	NNP
cord-001835-0s7ok4uw	2847	7	receptors	receptor	NNS
cord-001835-0s7ok4uw	2847	8	to	to	IN
cord-001835-0s7ok4uw	2847	9	collagen	collagen	NN
cord-001835-0s7ok4uw	2847	10	is	be	VBZ
cord-001835-0s7ok4uw	2847	11	cation	cation	NN
cord-001835-0s7ok4uw	2847	12	-	-	HYPH
cord-001835-0s7ok4uw	2847	13	dependent	dependent	JJ
cord-001835-0s7ok4uw	2847	14	with	with	IN
cord-001835-0s7ok4uw	2847	15	collagen	collagen	NN
cord-001835-0s7ok4uw	2847	16	binding	bind	VBG
cord-001835-0s7ok4uw	2847	17	a	a	DT
cord-001835-0s7ok4uw	2847	18	Mg(II	mg(ii	NN
cord-001835-0s7ok4uw	2847	19	)	)	-RRB-
cord-001835-0s7ok4uw	2847	20	ion	ion	NN
cord-001835-0s7ok4uw	2847	21	that	that	WDT
cord-001835-0s7ok4uw	2847	22	is	be	VBZ
cord-001835-0s7ok4uw	2847	23	located	locate	VBN
cord-001835-0s7ok4uw	2847	24	at	at	IN
cord-001835-0s7ok4uw	2847	25	the	the	DT
cord-001835-0s7ok4uw	2847	26	top	top	NN
cord-001835-0s7ok4uw	2847	27	of	of	IN
cord-001835-0s7ok4uw	2847	28	the	the	DT
cord-001835-0s7ok4uw	2847	29	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	2847	30	integrin	integrin	NN
cord-001835-0s7ok4uw	2847	31	a1I	a1i	NN
cord-001835-0s7ok4uw	2847	32	-	-	HYPH
cord-001835-0s7ok4uw	2847	33	domain	domain	NN
cord-001835-0s7ok4uw	2847	34	(	(	-LRB-
cord-001835-0s7ok4uw	2847	35	a1I	a1I	NNP
cord-001835-0s7ok4uw	2847	36	)	)	-RRB-
cord-001835-0s7ok4uw	2847	37	.	.	.
cord-001835-0s7ok4uw	2848	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2848	2	results	result	NNS
cord-001835-0s7ok4uw	2848	3	show	show	VBP
cord-001835-0s7ok4uw	2848	4	evidence	evidence	NN
cord-001835-0s7ok4uw	2848	5	for	for	IN
cord-001835-0s7ok4uw	2848	6	a	a	DT
cord-001835-0s7ok4uw	2848	7	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	2848	8	effect	effect	NN
cord-001835-0s7ok4uw	2848	9	of	of	IN
cord-001835-0s7ok4uw	2848	10	the	the	DT
cord-001835-0s7ok4uw	2848	11	Mg(II	mg(ii	NN
cord-001835-0s7ok4uw	2848	12	)	)	-RRB-
cord-001835-0s7ok4uw	2848	13	ion	ion	NN
cord-001835-0s7ok4uw	2848	14	on	on	IN
cord-001835-0s7ok4uw	2848	15	a1I	a1i	NN
cord-001835-0s7ok4uw	2848	16	affinity	affinity	NN
cord-001835-0s7ok4uw	2848	17	,	,	,
cord-001835-0s7ok4uw	2848	18	by	by	IN
cord-001835-0s7ok4uw	2848	19	inducing	induce	VBG
cord-001835-0s7ok4uw	2848	20	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2848	21	ms	ms	NNP
cord-001835-0s7ok4uw	2848	22	-	-	HYPH
cord-001835-0s7ok4uw	2848	23	ms	ms	NNP
cord-001835-0s7ok4uw	2848	24	motions	motion	NNS
cord-001835-0s7ok4uw	2848	25	of	of	IN
cord-001835-0s7ok4uw	2848	26	residues	residue	NNS
cord-001835-0s7ok4uw	2848	27	distant	distant	JJ
cord-001835-0s7ok4uw	2848	28	from	from	IN
cord-001835-0s7ok4uw	2848	29	the	the	DT
cord-001835-0s7ok4uw	2848	30	binding	binding	NN
cord-001835-0s7ok4uw	2848	31	site	site	NN
cord-001835-0s7ok4uw	2848	32	.	.	.
cord-001835-0s7ok4uw	2849	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2849	2	propose	propose	VBP
cord-001835-0s7ok4uw	2849	3	a	a	DT
cord-001835-0s7ok4uw	2849	4	novel	novel	JJ
cord-001835-0s7ok4uw	2849	5	model	model	NN
cord-001835-0s7ok4uw	2849	6	of	of	IN
cord-001835-0s7ok4uw	2849	7	a1I	a1I	NNP
cord-001835-0s7ok4uw	2849	8	recognition	recognition	NN
cord-001835-0s7ok4uw	2849	9	to	to	IN
cord-001835-0s7ok4uw	2849	10	collagen	collagen	NN
cord-001835-0s7ok4uw	2849	11	,	,	,
cord-001835-0s7ok4uw	2849	12	comprising	comprise	VBG
cord-001835-0s7ok4uw	2849	13	a	a	DT
cord-001835-0s7ok4uw	2849	14	two	two	CD
cord-001835-0s7ok4uw	2849	15	-	-	HYPH
cord-001835-0s7ok4uw	2849	16	step	step	NN
cord-001835-0s7ok4uw	2849	17	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2849	18	:	:	:
cord-001835-0s7ok4uw	2849	19	a	a	DT
cord-001835-0s7ok4uw	2849	20	conformational	conformational	JJ
cord-001835-0s7ok4uw	2849	21	selection	selection	NN
cord-001835-0s7ok4uw	2849	22	step	step	NN
cord-001835-0s7ok4uw	2849	23	,	,	,
cord-001835-0s7ok4uw	2849	24	induced	induce	VBN
cord-001835-0s7ok4uw	2849	25	by	by	IN
cord-001835-0s7ok4uw	2849	26	Mg(II	mg(ii	NN
cord-001835-0s7ok4uw	2849	27	)	)	-RRB-
cord-001835-0s7ok4uw	2849	28	coordination	coordination	NN
cord-001835-0s7ok4uw	2849	29	,	,	,
cord-001835-0s7ok4uw	2849	30	and	and	CC
cord-001835-0s7ok4uw	2849	31	an	an	DT
cord-001835-0s7ok4uw	2849	32	induced	induce	VBN
cord-001835-0s7ok4uw	2849	33	-	-	HYPH
cord-001835-0s7ok4uw	2849	34	fit	fit	JJ
cord-001835-0s7ok4uw	2849	35	step	step	NN
cord-001835-0s7ok4uw	2849	36	caused	cause	VBN
cord-001835-0s7ok4uw	2849	37	by	by	IN
cord-001835-0s7ok4uw	2849	38	collagen	collagen	NN
cord-001835-0s7ok4uw	2849	39	binding	binding	NN
cord-001835-0s7ok4uw	2849	40	.	.	.
cord-001835-0s7ok4uw	2850	1	Hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2850	2	-	-	HYPH
cord-001835-0s7ok4uw	2850	3	deuterium	deuterium	NN
cord-001835-0s7ok4uw	2850	4	exchange	exchange	NN
cord-001835-0s7ok4uw	2850	5	experiments	experiment	NNS
cord-001835-0s7ok4uw	2850	6	show	show	VBP
cord-001835-0s7ok4uw	2850	7	that	that	IN
cord-001835-0s7ok4uw	2850	8	the	the	DT
cord-001835-0s7ok4uw	2850	9	induced	induce	VBN
cord-001835-0s7ok4uw	2850	10	-	-	HYPH
cord-001835-0s7ok4uw	2850	11	fit	fit	JJ
cord-001835-0s7ok4uw	2850	12	step	step	NN
cord-001835-0s7ok4uw	2850	13	is	be	VBZ
cord-001835-0s7ok4uw	2850	14	facilitated	facilitate	VBN
cord-001835-0s7ok4uw	2850	15	by	by	IN
cord-001835-0s7ok4uw	2850	16	the	the	DT
cord-001835-0s7ok4uw	2850	17	reduced	reduce	VBN
cord-001835-0s7ok4uw	2850	18	local	local	JJ
cord-001835-0s7ok4uw	2850	19	stability	stability	NN
cord-001835-0s7ok4uw	2850	20	of	of	IN
cord-001835-0s7ok4uw	2850	21	the	the	DT
cord-001835-0s7ok4uw	2850	22	C	C	NNP
cord-001835-0s7ok4uw	2850	23	-	-	HYPH
cord-001835-0s7ok4uw	2850	24	terminus	terminus	NN
cord-001835-0s7ok4uw	2850	25	.	.	.
cord-001835-0s7ok4uw	2851	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2851	2	propose	propose	VBP
cord-001835-0s7ok4uw	2851	3	that	that	IN
cord-001835-0s7ok4uw	2851	4	the	the	DT
cord-001835-0s7ok4uw	2851	5	conformational	conformational	JJ
cord-001835-0s7ok4uw	2851	6	selection	selection	NN
cord-001835-0s7ok4uw	2851	7	step	step	NN
cord-001835-0s7ok4uw	2851	8	is	be	VBZ
cord-001835-0s7ok4uw	2851	9	the	the	DT
cord-001835-0s7ok4uw	2851	10	key	key	JJ
cord-001835-0s7ok4uw	2851	11	factor	factor	NN
cord-001835-0s7ok4uw	2851	12	that	that	WDT
cord-001835-0s7ok4uw	2851	13	allows	allow	VBZ
cord-001835-0s7ok4uw	2851	14	discrimination	discrimination	NN
cord-001835-0s7ok4uw	2851	15	between	between	IN
cord-001835-0s7ok4uw	2851	16	high	high	JJ
cord-001835-0s7ok4uw	2851	17	and	and	CC
cord-001835-0s7ok4uw	2851	18	low	low	JJ
cord-001835-0s7ok4uw	2851	19	affinity	affinity	NN
cord-001835-0s7ok4uw	2851	20	collagen	collagen	NN
cord-001835-0s7ok4uw	2851	21	sequences	sequence	NNS
cord-001835-0s7ok4uw	2851	22	.	.	.
cord-001835-0s7ok4uw	2851	23	 	 	_SP
cord-001835-0s7ok4uw	2852	1	Cytochromes	Cytochromes	NNP
cord-001835-0s7ok4uw	2852	2	P450	P450	NNP
cord-001835-0s7ok4uw	2852	3	(	(	-LRB-
cord-001835-0s7ok4uw	2852	4	CYP	CYP	NNP
cord-001835-0s7ok4uw	2852	5	)	)	-RRB-
cord-001835-0s7ok4uw	2852	6	are	be	VBP
cord-001835-0s7ok4uw	2852	7	heme	heme	NN
cord-001835-0s7ok4uw	2852	8	containing	contain	VBG
cord-001835-0s7ok4uw	2852	9	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	2852	10	involved	involve	VBN
cord-001835-0s7ok4uw	2852	11	in	in	IN
cord-001835-0s7ok4uw	2852	12	the	the	DT
cord-001835-0s7ok4uw	2852	13	metabolism	metabolism	NN
cord-001835-0s7ok4uw	2852	14	of	of	IN
cord-001835-0s7ok4uw	2852	15	endobiotics	endobiotic	NNS
cord-001835-0s7ok4uw	2852	16	and	and	CC
cord-001835-0s7ok4uw	2852	17	xenobiotics	xenobiotic	NNS
cord-001835-0s7ok4uw	2852	18	,	,	,
cord-001835-0s7ok4uw	2852	19	such	such	JJ
cord-001835-0s7ok4uw	2852	20	as	as	IN
cord-001835-0s7ok4uw	2852	21	drugs	drug	NNS
cord-001835-0s7ok4uw	2852	22	or	or	CC
cord-001835-0s7ok4uw	2852	23	pollutants	pollutant	NNS
cord-001835-0s7ok4uw	2852	24	.	.	.
cord-001835-0s7ok4uw	2853	1	[	[	-LRB-
cord-001835-0s7ok4uw	2853	2	1	1	CD
cord-001835-0s7ok4uw	2853	3	]	]	-RRB-
cord-001835-0s7ok4uw	2854	1	In	in	IN
cord-001835-0s7ok4uw	2854	2	humans	human	NNS
cord-001835-0s7ok4uw	2854	3	,	,	,
cord-001835-0s7ok4uw	2854	4	CYPs	cyp	NNS
cord-001835-0s7ok4uw	2854	5	are	be	VBP
cord-001835-0s7ok4uw	2854	6	attached	attach	VBN
cord-001835-0s7ok4uw	2854	7	to	to	IN
cord-001835-0s7ok4uw	2854	8	the	the	DT
cord-001835-0s7ok4uw	2854	9	biological	biological	JJ
cord-001835-0s7ok4uw	2854	10	membranes	membrane	NNS
cord-001835-0s7ok4uw	2854	11	of	of	IN
cord-001835-0s7ok4uw	2854	12	endoplasmic	endoplasmic	NN
cord-001835-0s7ok4uw	2854	13	reticulum	reticulum	NN
cord-001835-0s7ok4uw	2854	14	or	or	CC
cord-001835-0s7ok4uw	2854	15	mitochondria	mitochondrion	NNS
cord-001835-0s7ok4uw	2854	16	by	by	IN
cord-001835-0s7ok4uw	2854	17	N	n	CD
cord-001835-0s7ok4uw	2854	18	-	-	HYPH
cord-001835-0s7ok4uw	2854	19	terminal	terminal	NN
cord-001835-0s7ok4uw	2854	20	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	2854	21	anchor	anchor	NN
cord-001835-0s7ok4uw	2854	22	and	and	CC
cord-001835-0s7ok4uw	2854	23	they	-PRON-	PRP
cord-001835-0s7ok4uw	2854	24	are	be	VBP
cord-001835-0s7ok4uw	2854	25	partially	partially	RB
cord-001835-0s7ok4uw	2854	26	immersed	immerse	VBN
cord-001835-0s7ok4uw	2854	27	by	by	IN
cord-001835-0s7ok4uw	2854	28	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2854	29	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2854	30	domain	domain	NN
cord-001835-0s7ok4uw	2854	31	to	to	IN
cord-001835-0s7ok4uw	2854	32	different	different	JJ
cord-001835-0s7ok4uw	2854	33	level	level	NN
cord-001835-0s7ok4uw	2854	34	.	.	.
cord-001835-0s7ok4uw	2855	1	[	[	-LRB-
cord-001835-0s7ok4uw	2855	2	2	2	LS
cord-001835-0s7ok4uw	2855	3	]	]	-RRB-
cord-001835-0s7ok4uw	2855	4	Generally	generally	RB
cord-001835-0s7ok4uw	2855	5	,	,	,
cord-001835-0s7ok4uw	2855	6	the	the	DT
cord-001835-0s7ok4uw	2855	7	composition	composition	NN
cord-001835-0s7ok4uw	2855	8	of	of	IN
cord-001835-0s7ok4uw	2855	9	lipid	lipid	NN
cord-001835-0s7ok4uw	2855	10	membrane	membrane	NN
cord-001835-0s7ok4uw	2855	11	may	may	MD
cord-001835-0s7ok4uw	2855	12	significantly	significantly	RB
cord-001835-0s7ok4uw	2855	13	affect	affect	VB
cord-001835-0s7ok4uw	2855	14	behavior	behavior	NN
cord-001835-0s7ok4uw	2855	15	of	of	IN
cord-001835-0s7ok4uw	2855	16	protein	protein	NN
cord-001835-0s7ok4uw	2855	17	embedded	embed	VBN
cord-001835-0s7ok4uw	2855	18	in	in	IN
cord-001835-0s7ok4uw	2855	19	respective	respective	JJ
cord-001835-0s7ok4uw	2855	20	membrane	membrane	NN
cord-001835-0s7ok4uw	2856	1	e.g.	e.g.	RB
cord-001835-0s7ok4uw	2856	2	the	the	DT
cord-001835-0s7ok4uw	2856	3	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	2856	4	in	in	IN
cord-001835-0s7ok4uw	2856	5	membrane	membrane	NN
cord-001835-0s7ok4uw	2856	6	alters	alter	VBZ
cord-001835-0s7ok4uw	2856	7	membrane	membrane	NN
cord-001835-0s7ok4uw	2856	8	properties	property	NNS
cord-001835-0s7ok4uw	2856	9	such	such	JJ
cord-001835-0s7ok4uw	2856	10	as	as	IN
cord-001835-0s7ok4uw	2856	11	:	:	:
cord-001835-0s7ok4uw	2856	12	thickening	thickening	NN
cord-001835-0s7ok4uw	2856	13	of	of	IN
cord-001835-0s7ok4uw	2856	14	the	the	DT
cord-001835-0s7ok4uw	2856	15	membrane	membrane	NN
cord-001835-0s7ok4uw	2856	16	,	,	,
cord-001835-0s7ok4uw	2856	17	changing	change	VBG
cord-001835-0s7ok4uw	2856	18	the	the	DT
cord-001835-0s7ok4uw	2856	19	stiffness	stiffness	NN
cord-001835-0s7ok4uw	2856	20	or	or	CC
cord-001835-0s7ok4uw	2856	21	enhancing	enhance	VBG
cord-001835-0s7ok4uw	2856	22	ordering	ordering	NN
cord-001835-0s7ok4uw	2856	23	of	of	IN
cord-001835-0s7ok4uw	2856	24	the	the	DT
cord-001835-0s7ok4uw	2856	25	membrane	membrane	NN
cord-001835-0s7ok4uw	2856	26	.	.	.
cord-001835-0s7ok4uw	2857	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	2857	2	,	,	,
cord-001835-0s7ok4uw	2857	3	the	the	DT
cord-001835-0s7ok4uw	2857	4	increasing	increase	VBG
cord-001835-0s7ok4uw	2857	5	amount	amount	NN
cord-001835-0s7ok4uw	2857	6	of	of	IN
cord-001835-0s7ok4uw	2857	7	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	2857	8	in	in	IN
cord-001835-0s7ok4uw	2857	9	membrane	membrane	NN
cord-001835-0s7ok4uw	2857	10	may	may	MD
cord-001835-0s7ok4uw	2857	11	also	also	RB
cord-001835-0s7ok4uw	2857	12	alter	alter	VB
cord-001835-0s7ok4uw	2857	13	interaction	interaction	NN
cord-001835-0s7ok4uw	2857	14	with	with	IN
cord-001835-0s7ok4uw	2857	15	membrane	membrane	NN
cord-001835-0s7ok4uw	2857	16	proteins	protein	NNS
cord-001835-0s7ok4uw	2857	17	and	and	CC
cord-001835-0s7ok4uw	2857	18	affect	affect	VB
cord-001835-0s7ok4uw	2857	19	solute	solute	NN
cord-001835-0s7ok4uw	2857	20	partitioning	partitioning	NN
cord-001835-0s7ok4uw	2857	21	between	between	IN
cord-001835-0s7ok4uw	2857	22	membrane	membrane	NN
cord-001835-0s7ok4uw	2857	23	and	and	CC
cord-001835-0s7ok4uw	2857	24	water	water	NN
cord-001835-0s7ok4uw	2857	25	molecules	molecule	NNS
cord-001835-0s7ok4uw	2857	26	.	.	.
cord-001835-0s7ok4uw	2858	1	[	[	-LRB-
cord-001835-0s7ok4uw	2858	2	3	3	CD
cord-001835-0s7ok4uw	2858	3	]	]	-RRB-
cord-001835-0s7ok4uw	2858	4	Cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	2858	5	is	be	VBZ
cord-001835-0s7ok4uw	2858	6	also	also	RB
cord-001835-0s7ok4uw	2858	7	known	know	VBN
cord-001835-0s7ok4uw	2858	8	to	to	TO
cord-001835-0s7ok4uw	2858	9	noncompetitively	noncompetitively	RB
cord-001835-0s7ok4uw	2858	10	inhibit	inhibit	VB
cord-001835-0s7ok4uw	2858	11	the	the	DT
cord-001835-0s7ok4uw	2858	12	most	most	RBS
cord-001835-0s7ok4uw	2858	13	typical	typical	JJ
cord-001835-0s7ok4uw	2858	14	drugmetabolizing	drugmetabolizing	NN
cord-001835-0s7ok4uw	2858	15	CYP	CYP	NNP
cord-001835-0s7ok4uw	2858	16	-CYP3A4	-CYP3A4	NNP
cord-001835-0s7ok4uw	2858	17	,	,	,
cord-001835-0s7ok4uw	2858	18	[	[	-LRB-
cord-001835-0s7ok4uw	2858	19	4	4	CD
cord-001835-0s7ok4uw	2858	20	]	]	-RRB-
cord-001835-0s7ok4uw	2858	21	however	however	RB
cord-001835-0s7ok4uw	2858	22	the	the	DT
cord-001835-0s7ok4uw	2858	23	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2858	24	was	be	VBD
cord-001835-0s7ok4uw	2858	25	unknown	unknown	JJ
cord-001835-0s7ok4uw	2858	26	.	.	.
cord-001835-0s7ok4uw	2859	1	For	for	IN
cord-001835-0s7ok4uw	2859	2	this	this	DT
cord-001835-0s7ok4uw	2859	3	reason	reason	NN
cord-001835-0s7ok4uw	2859	4	,	,	,
cord-001835-0s7ok4uw	2859	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2859	6	prepared	prepare	VBD
cord-001835-0s7ok4uw	2859	7	the	the	DT
cord-001835-0s7ok4uw	2859	8	set	set	NN
cord-001835-0s7ok4uw	2859	9	of	of	IN
cord-001835-0s7ok4uw	2859	10	simulations	simulation	NNS
cord-001835-0s7ok4uw	2859	11	of	of	IN
cord-001835-0s7ok4uw	2859	12	CYP3A4	cyp3a4	NN
cord-001835-0s7ok4uw	2859	13	embedded	embed	VBN
cord-001835-0s7ok4uw	2859	14	in	in	IN
cord-001835-0s7ok4uw	2859	15	DOPC	DOPC	NNP
cord-001835-0s7ok4uw	2859	16	lipid	lipid	NN
cord-001835-0s7ok4uw	2859	17	bilayers	bilayer	NNS
cord-001835-0s7ok4uw	2859	18	with	with	IN
cord-001835-0s7ok4uw	2859	19	various	various	JJ
cord-001835-0s7ok4uw	2859	20	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	2859	21	concentrations	concentration	NNS
cord-001835-0s7ok4uw	2859	22	(	(	-LRB-
cord-001835-0s7ok4uw	2859	23	0	0	CD
cord-001835-0s7ok4uw	2859	24	,	,	,
cord-001835-0s7ok4uw	2859	25	3	3	CD
cord-001835-0s7ok4uw	2859	26	,	,	,
cord-001835-0s7ok4uw	2859	27	6	6	CD
cord-001835-0s7ok4uw	2859	28	,	,	,
cord-001835-0s7ok4uw	2859	29	20	20	CD
cord-001835-0s7ok4uw	2859	30	and	and	CC
cord-001835-0s7ok4uw	2859	31	50	50	CD
cord-001835-0s7ok4uw	2859	32	%	%	NN
cord-001835-0s7ok4uw	2859	33	wt	wt	NN
cord-001835-0s7ok4uw	2859	34	;	;	:
cord-001835-0s7ok4uw	2859	35	Figure	figure	NN
cord-001835-0s7ok4uw	2859	36	1	1	CD
cord-001835-0s7ok4uw	2859	37	)	)	-RRB-
cord-001835-0s7ok4uw	2859	38	and	and	CC
cord-001835-0s7ok4uw	2859	39	the	the	DT
cord-001835-0s7ok4uw	2859	40	200ns1	200ns1	JJ
cord-001835-0s7ok4uw	2859	41	long	long	JJ
cord-001835-0s7ok4uw	2859	42	MD	MD	NNP
cord-001835-0s7ok4uw	2859	43	simulations	simulation	NNS
cord-001835-0s7ok4uw	2859	44	were	be	VBD
cord-001835-0s7ok4uw	2859	45	carried	carry	VBN
cord-001835-0s7ok4uw	2859	46	out	out	RP
cord-001835-0s7ok4uw	2859	47	.	.	.
cord-001835-0s7ok4uw	2860	1	MD	MD	NNP
cord-001835-0s7ok4uw	2860	2	simulations	simulation	NNS
cord-001835-0s7ok4uw	2860	3	showed	show	VBD
cord-001835-0s7ok4uw	2860	4	the	the	DT
cord-001835-0s7ok4uw	2860	5	formation	formation	NN
cord-001835-0s7ok4uw	2860	6	of	of	IN
cord-001835-0s7ok4uw	2860	7	funnel	funnel	NN
cord-001835-0s7ok4uw	2860	8	-	-	HYPH
cord-001835-0s7ok4uw	2860	9	like	like	JJ
cord-001835-0s7ok4uw	2860	10	shape	shape	NN
cord-001835-0s7ok4uw	2860	11	of	of	IN
cord-001835-0s7ok4uw	2860	12	the	the	DT
cord-001835-0s7ok4uw	2860	13	lipids	lipid	NNS
cord-001835-0s7ok4uw	2860	14	close	close	RB
cord-001835-0s7ok4uw	2860	15	to	to	IN
cord-001835-0s7ok4uw	2860	16	the	the	DT
cord-001835-0s7ok4uw	2860	17	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2860	18	domain	domain	NN
cord-001835-0s7ok4uw	2860	19	of	of	IN
cord-001835-0s7ok4uw	2860	20	CYP	CYP	NNP
cord-001835-0s7ok4uw	2860	21	.	.	.
cord-001835-0s7ok4uw	2861	1	In	in	IN
cord-001835-0s7ok4uw	2861	2	addition	addition	NN
cord-001835-0s7ok4uw	2861	3	,	,	,
cord-001835-0s7ok4uw	2861	4	the	the	DT
cord-001835-0s7ok4uw	2861	5	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	2861	6	molecules	molecule	NNS
cord-001835-0s7ok4uw	2861	7	have	have	VBP
cord-001835-0s7ok4uw	2861	8	tendency	tendency	NN
cord-001835-0s7ok4uw	2861	9	to	to	TO
cord-001835-0s7ok4uw	2861	10	accumulate	accumulate	VB
cord-001835-0s7ok4uw	2861	11	in	in	IN
cord-001835-0s7ok4uw	2861	12	the	the	DT
cord-001835-0s7ok4uw	2861	13	vicinity	vicinity	NN
cord-001835-0s7ok4uw	2861	14	of	of	IN
cord-001835-0s7ok4uw	2861	15	membrane	membrane	NN
cord-001835-0s7ok4uw	2861	16	-	-	HYPH
cord-001835-0s7ok4uw	2861	17	attached	attach	VBN
cord-001835-0s7ok4uw	2861	18	F	F	NNP
cord-001835-0s7ok4uw	2861	19	/	/	SYM
cord-001835-0s7ok4uw	2861	20	G	g	NN
cord-001835-0s7ok4uw	2861	21	loop	loop	NN
cord-001835-0s7ok4uw	2861	22	.	.	.
cord-001835-0s7ok4uw	2862	1	The	the	DT
cord-001835-0s7ok4uw	2862	2	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2862	3	domain	domain	NN
cord-001835-0s7ok4uw	2862	4	sunk	sink	VBD
cord-001835-0s7ok4uw	2862	5	deeper	deeply	RBR
cord-001835-0s7ok4uw	2862	6	into	into	IN
cord-001835-0s7ok4uw	2862	7	the	the	DT
cord-001835-0s7ok4uw	2862	8	membrane	membrane	NN
cord-001835-0s7ok4uw	2862	9	with	with	IN
cord-001835-0s7ok4uw	2862	10	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	2862	11	and	and	CC
cord-001835-0s7ok4uw	2862	12	also	also	RB
cord-001835-0s7ok4uw	2862	13	the	the	DT
cord-001835-0s7ok4uw	2862	14	number	number	NN
cord-001835-0s7ok4uw	2862	15	of	of	IN
cord-001835-0s7ok4uw	2862	16	amino	amino	JJ
cord-001835-0s7ok4uw	2862	17	acids	acid	NNS
cord-001835-0s7ok4uw	2862	18	in	in	IN
cord-001835-0s7ok4uw	2862	19	contact	contact	NN
cord-001835-0s7ok4uw	2862	20	with	with	IN
cord-001835-0s7ok4uw	2862	21	membrane	membrane	NN
cord-001835-0s7ok4uw	2862	22	was	be	VBD
cord-001835-0s7ok4uw	2862	23	bigger	big	JJR
cord-001835-0s7ok4uw	2862	24	than	than	IN
cord-001835-0s7ok4uw	2862	25	in	in	IN
cord-001835-0s7ok4uw	2862	26	the	the	DT
cord-001835-0s7ok4uw	2862	27	pure	pure	JJ
cord-001835-0s7ok4uw	2862	28	DOPC	DOPC	NNP
cord-001835-0s7ok4uw	2862	29	bilayer	bilayer	NN
cord-001835-0s7ok4uw	2862	30	.	.	.
cord-001835-0s7ok4uw	2863	1	In	in	IN
cord-001835-0s7ok4uw	2863	2	contrast	contrast	NN
cord-001835-0s7ok4uw	2863	3	,	,	,
cord-001835-0s7ok4uw	2863	4	the	the	DT
cord-001835-0s7ok4uw	2863	5	presence	presence	NN
cord-001835-0s7ok4uw	2863	6	of	of	IN
cord-001835-0s7ok4uw	2863	7	higher	high	JJR
cord-001835-0s7ok4uw	2863	8	amount	amount	NN
cord-001835-0s7ok4uw	2863	9	of	of	IN
cord-001835-0s7ok4uw	2863	10	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	2863	11	affected	affect	VBD
cord-001835-0s7ok4uw	2863	12	the	the	DT
cord-001835-0s7ok4uw	2863	13	pattern	pattern	NN
cord-001835-0s7ok4uw	2863	14	of	of	IN
cord-001835-0s7ok4uw	2863	15	channel	channel	NN
cord-001835-0s7ok4uw	2863	16	opening	opening	NN
cord-001835-0s7ok4uw	2863	17	effectively	effectively	RB
cord-001835-0s7ok4uw	2863	18	blocking	block	VBG
cord-001835-0s7ok4uw	2863	19	the	the	DT
cord-001835-0s7ok4uw	2863	20	access	access	NN
cord-001835-0s7ok4uw	2863	21	to	to	IN
cord-001835-0s7ok4uw	2863	22	the	the	DT
cord-001835-0s7ok4uw	2863	23	active	active	JJ
cord-001835-0s7ok4uw	2863	24	site	site	NN
cord-001835-0s7ok4uw	2863	25	from	from	IN
cord-001835-0s7ok4uw	2863	26	the	the	DT
cord-001835-0s7ok4uw	2863	27	membrane	membrane	NN
cord-001835-0s7ok4uw	2863	28	,	,	,
cord-001835-0s7ok4uw	2863	29	which	which	WDT
cord-001835-0s7ok4uw	2863	30	in	in	IN
cord-001835-0s7ok4uw	2863	31	turn	turn	NN
cord-001835-0s7ok4uw	2863	32	may	may	MD
cord-001835-0s7ok4uw	2863	33	affect	affect	VB
cord-001835-0s7ok4uw	2863	34	the	the	DT
cord-001835-0s7ok4uw	2863	35	substrate	substrate	NN
cord-001835-0s7ok4uw	2863	36	preferences	preference	NNS
cord-001835-0s7ok4uw	2863	37	and	and	CC
cord-001835-0s7ok4uw	2863	38	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2863	39	efficiency	efficiency	NN
cord-001835-0s7ok4uw	2863	40	.	.	.
cord-001835-0s7ok4uw	2864	1	[	[	-LRB-
cord-001835-0s7ok4uw	2864	2	5	5	LS
cord-001835-0s7ok4uw	2864	3	]	]	-RRB-
cord-001835-0s7ok4uw	2864	4	Finally	finally	RB
cord-001835-0s7ok4uw	2864	5	,	,	,
cord-001835-0s7ok4uw	2864	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	2864	7	study	study	VBP
cord-001835-0s7ok4uw	2864	8	the	the	DT
cord-001835-0s7ok4uw	2864	9	effect	effect	NN
cord-001835-0s7ok4uw	2864	10	of	of	IN
cord-001835-0s7ok4uw	2864	11	different	different	JJ
cord-001835-0s7ok4uw	2864	12	lipid	lipid	NN
cord-001835-0s7ok4uw	2864	13	types	type	NNS
cord-001835-0s7ok4uw	2864	14	on	on	IN
cord-001835-0s7ok4uw	2864	15	membrane	membrane	NN
cord-001835-0s7ok4uw	2864	16	-	-	HYPH
cord-001835-0s7ok4uw	2864	17	attached	attach	VBN
cord-001835-0s7ok4uw	2864	18	CYP3A4	CYP3A4	NNP
cord-001835-0s7ok4uw	2864	19	.	.	.
cord-001835-0s7ok4uw	2865	1	Anti-(4-hydroxy-3-nitrophenyl)acetyl	Anti-(4-hydroxy-3-nitrophenyl)acetyl	NNP
cord-001835-0s7ok4uw	2866	1	(	(	-LRB-
cord-001835-0s7ok4uw	2866	2	NP	NP	NNP
cord-001835-0s7ok4uw	2866	3	)	)	-RRB-
cord-001835-0s7ok4uw	2866	4	antibodies	antibody	NNS
cord-001835-0s7ok4uw	2866	5	are	be	VBP
cord-001835-0s7ok4uw	2866	6	one	one	CD
cord-001835-0s7ok4uw	2866	7	of	of	IN
cord-001835-0s7ok4uw	2866	8	the	the	DT
cord-001835-0s7ok4uw	2866	9	most	most	RBS
cord-001835-0s7ok4uw	2866	10	widely	widely	RB
cord-001835-0s7ok4uw	2866	11	analyzed	analyze	VBN
cord-001835-0s7ok4uw	2866	12	type	type	NN
cord-001835-0s7ok4uw	2866	13	of	of	IN
cord-001835-0s7ok4uw	2866	14	antibodies	antibody	NNS
cord-001835-0s7ok4uw	2866	15	,	,	,
cord-001835-0s7ok4uw	2866	16	especially	especially	RB
cord-001835-0s7ok4uw	2866	17	with	with	IN
cord-001835-0s7ok4uw	2866	18	respect	respect	NN
cord-001835-0s7ok4uw	2866	19	to	to	IN
cord-001835-0s7ok4uw	2866	20	affinity	affinity	NN
cord-001835-0s7ok4uw	2866	21	maturation	maturation	NN
cord-001835-0s7ok4uw	2866	22	[	[	-LRB-
cord-001835-0s7ok4uw	2866	23	1	1	CD
cord-001835-0s7ok4uw	2866	24	]	]	-RRB-
cord-001835-0s7ok4uw	2866	25	[	[	-LRB-
cord-001835-0s7ok4uw	2866	26	2	2	CD
cord-001835-0s7ok4uw	2866	27	]	]	-RRB-
cord-001835-0s7ok4uw	2866	28	[	[	-LRB-
cord-001835-0s7ok4uw	2866	29	3	3	CD
cord-001835-0s7ok4uw	2866	30	]	]	-RRB-
cord-001835-0s7ok4uw	2866	31	.	.	.
cord-001835-0s7ok4uw	2867	1	Affinity	affinity	NN
cord-001835-0s7ok4uw	2867	2	maturation	maturation	NN
cord-001835-0s7ok4uw	2867	3	is	be	VBZ
cord-001835-0s7ok4uw	2867	4	a	a	DT
cord-001835-0s7ok4uw	2867	5	process	process	NN
cord-001835-0s7ok4uw	2867	6	in	in	IN
cord-001835-0s7ok4uw	2867	7	which	which	WDT
cord-001835-0s7ok4uw	2867	8	B	b	NN
cord-001835-0s7ok4uw	2867	9	cells	cell	NNS
cord-001835-0s7ok4uw	2867	10	produce	produce	VBP
cord-001835-0s7ok4uw	2867	11	antibodies	antibody	NNS
cord-001835-0s7ok4uw	2867	12	with	with	IN
cord-001835-0s7ok4uw	2867	13	increased	increase	VBN
cord-001835-0s7ok4uw	2867	14	affinity	affinity	NN
cord-001835-0s7ok4uw	2867	15	for	for	IN
cord-001835-0s7ok4uw	2867	16	the	the	DT
cord-001835-0s7ok4uw	2867	17	antigen	antigen	NN
cord-001835-0s7ok4uw	2867	18	during	during	IN
cord-001835-0s7ok4uw	2867	19	the	the	DT
cord-001835-0s7ok4uw	2867	20	course	course	NN
cord-001835-0s7ok4uw	2867	21	of	of	IN
cord-001835-0s7ok4uw	2867	22	an	an	DT
cord-001835-0s7ok4uw	2867	23	immune	immune	JJ
cord-001835-0s7ok4uw	2867	24	response	response	NN
cord-001835-0s7ok4uw	2867	25	,	,	,
cord-001835-0s7ok4uw	2867	26	and	and	CC
cord-001835-0s7ok4uw	2867	27	is	be	VBZ
cord-001835-0s7ok4uw	2867	28	like	like	IN
cord-001835-0s7ok4uw	2867	29	"	"	``
cord-001835-0s7ok4uw	2867	30	evolution	evolution	NN
cord-001835-0s7ok4uw	2867	31	"	"	''
cord-001835-0s7ok4uw	2867	32	in	in	IN
cord-001835-0s7ok4uw	2867	33	term	term	NN
cord-001835-0s7ok4uw	2867	34	of	of	IN
cord-001835-0s7ok4uw	2867	35	increasing	increase	VBG
cord-001835-0s7ok4uw	2867	36	antigen	antigen	NN
cord-001835-0s7ok4uw	2867	37	-	-	HYPH
cord-001835-0s7ok4uw	2867	38	binding	bind	VBG
cord-001835-0s7ok4uw	2867	39	affinity	affinity	NN
cord-001835-0s7ok4uw	2867	40	.	.	.
cord-001835-0s7ok4uw	2868	1	During	during	IN
cord-001835-0s7ok4uw	2868	2	the	the	DT
cord-001835-0s7ok4uw	2868	3	course	course	NN
cord-001835-0s7ok4uw	2868	4	of	of	IN
cord-001835-0s7ok4uw	2868	5	affinity	affinity	NN
cord-001835-0s7ok4uw	2868	6	maturation	maturation	NN
cord-001835-0s7ok4uw	2868	7	,	,	,
cord-001835-0s7ok4uw	2868	8	the	the	DT
cord-001835-0s7ok4uw	2868	9	structural	structural	JJ
cord-001835-0s7ok4uw	2868	10	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2868	11	of	of	IN
cord-001835-0s7ok4uw	2868	12	antibodies	antibody	NNS
cord-001835-0s7ok4uw	2868	13	,	,	,
cord-001835-0s7ok4uw	2868	14	which	which	WDT
cord-001835-0s7ok4uw	2868	15	are	be	VBP
cord-001835-0s7ok4uw	2868	16	closely	closely	RB
cord-001835-0s7ok4uw	2868	17	correlated	correlate	VBN
cord-001835-0s7ok4uw	2868	18	with	with	IN
cord-001835-0s7ok4uw	2868	19	the	the	DT
cord-001835-0s7ok4uw	2868	20	binding	binding	NN
cord-001835-0s7ok4uw	2868	21	function	function	NN
cord-001835-0s7ok4uw	2868	22	,	,	,
cord-001835-0s7ok4uw	2868	23	can	can	MD
cord-001835-0s7ok4uw	2868	24	change	change	VB
cord-001835-0s7ok4uw	2868	25	.	.	.
cord-001835-0s7ok4uw	2869	1	To	to	TO
cord-001835-0s7ok4uw	2869	2	analyze	analyze	VB
cord-001835-0s7ok4uw	2869	3	the	the	DT
cord-001835-0s7ok4uw	2869	4	structural	structural	JJ
cord-001835-0s7ok4uw	2869	5	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2869	6	at	at	IN
cord-001835-0s7ok4uw	2869	7	atomic	atomic	JJ
cord-001835-0s7ok4uw	2869	8	resolution	resolution	NN
cord-001835-0s7ok4uw	2869	9	and	and	CC
cord-001835-0s7ok4uw	2869	10	the	the	DT
cord-001835-0s7ok4uw	2869	11	single	single	JJ
cord-001835-0s7ok4uw	2869	12	-	-	HYPH
cord-001835-0s7ok4uw	2869	13	molecule	molecule	NN
cord-001835-0s7ok4uw	2869	14	level	level	NN
cord-001835-0s7ok4uw	2869	15	,	,	,
cord-001835-0s7ok4uw	2869	16	we	-PRON-	PRP
cord-001835-0s7ok4uw	2869	17	tried	try	VBD
cord-001835-0s7ok4uw	2869	18	to	to	TO
cord-001835-0s7ok4uw	2869	19	express	express	VB
cord-001835-0s7ok4uw	2869	20	and	and	CC
cord-001835-0s7ok4uw	2869	21	purify	purify	VB
cord-001835-0s7ok4uw	2869	22	single	single	JJ
cord-001835-0s7ok4uw	2869	23	-	-	HYPH
cord-001835-0s7ok4uw	2869	24	chain	chain	NN
cord-001835-0s7ok4uw	2869	25	Fv	Fv	NNP
cord-001835-0s7ok4uw	2869	26	(	(	-LRB-
cord-001835-0s7ok4uw	2869	27	scFv	scFv	NNP
cord-001835-0s7ok4uw	2869	28	)	)	-RRB-
cord-001835-0s7ok4uw	2869	29	antibodies	antibody	NNS
cord-001835-0s7ok4uw	2869	30	against	against	IN
cord-001835-0s7ok4uw	2869	31	NP	NP	NNP
cord-001835-0s7ok4uw	2869	32	.	.	.
cord-001835-0s7ok4uw	2870	1	Using	use	VBG
cord-001835-0s7ok4uw	2870	2	scFv	scfv	JJ
cord-001835-0s7ok4uw	2870	3	antibodies	antibody	NNS
cord-001835-0s7ok4uw	2870	4	,	,	,
cord-001835-0s7ok4uw	2870	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2870	6	can	can	MD
cord-001835-0s7ok4uw	2870	7	also	also	RB
cord-001835-0s7ok4uw	2870	8	analyze	analyze	VB
cord-001835-0s7ok4uw	2870	9	the	the	DT
cord-001835-0s7ok4uw	2870	10	effects	effect	NNS
cord-001835-0s7ok4uw	2870	11	of	of	IN
cord-001835-0s7ok4uw	2870	12	key	key	JJ
cord-001835-0s7ok4uw	2870	13	residues	residue	NNS
cord-001835-0s7ok4uw	2870	14	on	on	IN
cord-001835-0s7ok4uw	2870	15	affinity	affinity	NN
cord-001835-0s7ok4uw	2870	16	maturation	maturation	NN
cord-001835-0s7ok4uw	2870	17	via	via	IN
cord-001835-0s7ok4uw	2870	18	site	site	NN
cord-001835-0s7ok4uw	2870	19	-	-	HYPH
cord-001835-0s7ok4uw	2870	20	directed	direct	VBN
cord-001835-0s7ok4uw	2870	21	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	2870	22	.	.	.
cord-001835-0s7ok4uw	2871	1	As	as	IN
cord-001835-0s7ok4uw	2871	2	the	the	DT
cord-001835-0s7ok4uw	2871	3	first	first	JJ
cord-001835-0s7ok4uw	2871	4	step	step	NN
cord-001835-0s7ok4uw	2871	5	,	,	,
cord-001835-0s7ok4uw	2871	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	2871	7	have	have	VBP
cord-001835-0s7ok4uw	2871	8	succeeded	succeed	VBN
cord-001835-0s7ok4uw	2871	9	in	in	IN
cord-001835-0s7ok4uw	2871	10	generating	generate	VBG
cord-001835-0s7ok4uw	2871	11	a	a	DT
cord-001835-0s7ok4uw	2871	12	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	2871	13	quantity	quantity	NN
cord-001835-0s7ok4uw	2871	14	and	and	CC
cord-001835-0s7ok4uw	2871	15	good	good	JJ
cord-001835-0s7ok4uw	2871	16	quality	quality	NN
cord-001835-0s7ok4uw	2871	17	of	of	IN
cord-001835-0s7ok4uw	2871	18	scFv	scfv	NN
cord-001835-0s7ok4uw	2871	19	of	of	IN
cord-001835-0s7ok4uw	2871	20	affinity	affinity	NN
cord-001835-0s7ok4uw	2871	21	-	-	HYPH
cord-001835-0s7ok4uw	2871	22	mature	mature	JJ
cord-001835-0s7ok4uw	2871	23	anti	anti	JJ
cord-001835-0s7ok4uw	2871	24	-	-	JJ
cord-001835-0s7ok4uw	2871	25	NP	NP	NNP
cord-001835-0s7ok4uw	2871	26	antibody	antibody	NN
cord-001835-0s7ok4uw	2871	27	,	,	,
cord-001835-0s7ok4uw	2871	28	C6	C6	NNP
cord-001835-0s7ok4uw	2871	29	,	,	,
cord-001835-0s7ok4uw	2871	30	with	with	IN
cord-001835-0s7ok4uw	2871	31	a	a	DT
cord-001835-0s7ok4uw	2871	32	linker	linker	NN
cord-001835-0s7ok4uw	2871	33	composed	compose	VBN
cord-001835-0s7ok4uw	2871	34	of	of	IN
cord-001835-0s7ok4uw	2871	35	four	four	CD
cord-001835-0s7ok4uw	2871	36	repeats	repeat	NNS
cord-001835-0s7ok4uw	2871	37	of	of	IN
cord-001835-0s7ok4uw	2871	38	GGGS	GGGS	NNP
cord-001835-0s7ok4uw	2871	39	.	.	.
cord-001835-0s7ok4uw	2872	1	The	the	DT
cord-001835-0s7ok4uw	2872	2	scFv	scfv	JJ
cord-001835-0s7ok4uw	2872	3	protein	protein	NN
cord-001835-0s7ok4uw	2872	4	was	be	VBD
cord-001835-0s7ok4uw	2872	5	expressed	express	VBN
cord-001835-0s7ok4uw	2872	6	in	in	IN
cord-001835-0s7ok4uw	2872	7	the	the	DT
cord-001835-0s7ok4uw	2872	8	insoluble	insoluble	JJ
cord-001835-0s7ok4uw	2872	9	fraction	fraction	NN
cord-001835-0s7ok4uw	2872	10	of	of	IN
cord-001835-0s7ok4uw	2872	11	E.	E.	NNP
cord-001835-0s7ok4uw	2872	12	coli	coli	NNS
cord-001835-0s7ok4uw	2872	13	,	,	,
cord-001835-0s7ok4uw	2872	14	and	and	CC
cord-001835-0s7ok4uw	2872	15	solubilized	solubilize	VBD
cord-001835-0s7ok4uw	2872	16	using	use	VBG
cord-001835-0s7ok4uw	2872	17	8	8	CD
cord-001835-0s7ok4uw	2872	18	M	M	NNP
cord-001835-0s7ok4uw	2872	19	urea	urea	NN
cord-001835-0s7ok4uw	2872	20	,	,	,
cord-001835-0s7ok4uw	2872	21	followed	follow	VBN
cord-001835-0s7ok4uw	2872	22	by	by	IN
cord-001835-0s7ok4uw	2872	23	refolding	refolde	VBG
cord-001835-0s7ok4uw	2872	24	by	by	IN
cord-001835-0s7ok4uw	2872	25	step	step	NN
cord-001835-0s7ok4uw	2872	26	-	-	HYPH
cord-001835-0s7ok4uw	2872	27	wise	wise	JJ
cord-001835-0s7ok4uw	2872	28	dialysis	dialysis	NN
cord-001835-0s7ok4uw	2872	29	to	to	TO
cord-001835-0s7ok4uw	2872	30	decrease	decrease	VB
cord-001835-0s7ok4uw	2872	31	the	the	DT
cord-001835-0s7ok4uw	2872	32	urea	urea	NN
cord-001835-0s7ok4uw	2872	33	concentration	concentration	NN
cord-001835-0s7ok4uw	2872	34	.	.	.
cord-001835-0s7ok4uw	2873	1	The	the	DT
cord-001835-0s7ok4uw	2873	2	final	final	JJ
cord-001835-0s7ok4uw	2873	3	step	step	NN
cord-001835-0s7ok4uw	2873	4	of	of	IN
cord-001835-0s7ok4uw	2873	5	purification	purification	NN
cord-001835-0s7ok4uw	2873	6	using	use	VBG
cord-001835-0s7ok4uw	2873	7	an	an	DT
cord-001835-0s7ok4uw	2873	8	antigen	antigen	NN
cord-001835-0s7ok4uw	2873	9	column	column	NN
cord-001835-0s7ok4uw	2873	10	indicated	indicate	VBD
cord-001835-0s7ok4uw	2873	11	that	that	IN
cord-001835-0s7ok4uw	2873	12	approximately	approximately	RB
cord-001835-0s7ok4uw	2873	13	2	2	CD
cord-001835-0s7ok4uw	2873	14	%	%	NN
cord-001835-0s7ok4uw	2873	15	of	of	IN
cord-001835-0s7ok4uw	2873	16	the	the	DT
cord-001835-0s7ok4uw	2873	17	solubilized	solubilized	JJ
cord-001835-0s7ok4uw	2873	18	protein	protein	NN
cord-001835-0s7ok4uw	2873	19	was	be	VBD
cord-001835-0s7ok4uw	2873	20	correctly	correctly	RB
cord-001835-0s7ok4uw	2873	21	refolded	refolde	VBN
cord-001835-0s7ok4uw	2873	22	and	and	CC
cord-001835-0s7ok4uw	2873	23	possessed	possess	VBD
cord-001835-0s7ok4uw	2873	24	antigen	antigen	NN
cord-001835-0s7ok4uw	2873	25	-	-	HYPH
cord-001835-0s7ok4uw	2873	26	binding	bind	VBG
cord-001835-0s7ok4uw	2873	27	ability	ability	NN
cord-001835-0s7ok4uw	2873	28	.	.	.
cord-001835-0s7ok4uw	2874	1	The	the	DT
cord-001835-0s7ok4uw	2874	2	analytical	analytical	JJ
cord-001835-0s7ok4uw	2874	3	ultracentrifugation	ultracentrifugation	NN
cord-001835-0s7ok4uw	2874	4	(	(	-LRB-
cord-001835-0s7ok4uw	2874	5	AUC	AUC	NNP
cord-001835-0s7ok4uw	2874	6	)	)	-RRB-
cord-001835-0s7ok4uw	2874	7	analysis	analysis	NN
cord-001835-0s7ok4uw	2874	8	showed	show	VBD
cord-001835-0s7ok4uw	2874	9	that	that	IN
cord-001835-0s7ok4uw	2874	10	the	the	DT
cord-001835-0s7ok4uw	2874	11	purified	purify	VBN
cord-001835-0s7ok4uw	2874	12	C6	c6	NN
cord-001835-0s7ok4uw	2874	13	scFv	scfv	NN
cord-001835-0s7ok4uw	2874	14	exists	exist	VBZ
cord-001835-0s7ok4uw	2874	15	in	in	IN
cord-001835-0s7ok4uw	2874	16	the	the	DT
cord-001835-0s7ok4uw	2874	17	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	2874	18	state	state	NN
cord-001835-0s7ok4uw	2874	19	with	with	IN
cord-001835-0s7ok4uw	2874	20	little	little	JJ
cord-001835-0s7ok4uw	2874	21	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	2874	22	contamination	contamination	NN
cord-001835-0s7ok4uw	2874	23	.	.	.
cord-001835-0s7ok4uw	2875	1	The	the	DT
cord-001835-0s7ok4uw	2875	2	secondary	secondary	JJ
cord-001835-0s7ok4uw	2875	3	structure	structure	NN
cord-001835-0s7ok4uw	2875	4	and	and	CC
cord-001835-0s7ok4uw	2875	5	thermal	thermal	JJ
cord-001835-0s7ok4uw	2875	6	stability	stability	NN
cord-001835-0s7ok4uw	2875	7	of	of	IN
cord-001835-0s7ok4uw	2875	8	C6	c6	NN
cord-001835-0s7ok4uw	2875	9	scFv	scFv	NNS
cord-001835-0s7ok4uw	2875	10	were	be	VBD
cord-001835-0s7ok4uw	2875	11	analyzed	analyze	VBN
cord-001835-0s7ok4uw	2875	12	using	use	VBG
cord-001835-0s7ok4uw	2875	13	circular	circular	JJ
cord-001835-0s7ok4uw	2875	14	dichroism	dichroism	NN
cord-001835-0s7ok4uw	2875	15	(	(	-LRB-
cord-001835-0s7ok4uw	2875	16	CD	CD	NNP
cord-001835-0s7ok4uw	2875	17	)	)	-RRB-
cord-001835-0s7ok4uw	2875	18	.	.	.
cord-001835-0s7ok4uw	2876	1	The	the	DT
cord-001835-0s7ok4uw	2876	2	far	far	JJ
cord-001835-0s7ok4uw	2876	3	-	-	HYPH
cord-001835-0s7ok4uw	2876	4	UV	uv	NN
cord-001835-0s7ok4uw	2876	5	CD	cd	NN
cord-001835-0s7ok4uw	2876	6	spectra	spectrum	NNS
cord-001835-0s7ok4uw	2876	7	of	of	IN
cord-001835-0s7ok4uw	2876	8	C6	C6	NNP
cord-001835-0s7ok4uw	2876	9	scFv	scFv	NNP
cord-001835-0s7ok4uw	2876	10	indicated	indicate	VBD
cord-001835-0s7ok4uw	2876	11	typical	typical	JJ
cord-001835-0s7ok4uw	2876	12	b	b	NN
cord-001835-0s7ok4uw	2876	13	-	-	HYPH
cord-001835-0s7ok4uw	2876	14	sheet	sheet	NN
cord-001835-0s7ok4uw	2876	15	-	-	HYPH
cord-001835-0s7ok4uw	2876	16	rich	rich	JJ
cord-001835-0s7ok4uw	2876	17	structures	structure	NNS
cord-001835-0s7ok4uw	2876	18	.	.	.
cord-001835-0s7ok4uw	2877	1	Upon	upon	IN
cord-001835-0s7ok4uw	2877	2	antigen	antigen	NN
cord-001835-0s7ok4uw	2877	3	binding	binding	NN
cord-001835-0s7ok4uw	2877	4	,	,	,
cord-001835-0s7ok4uw	2877	5	the	the	DT
cord-001835-0s7ok4uw	2877	6	far	far	JJ
cord-001835-0s7ok4uw	2877	7	-	-	HYPH
cord-001835-0s7ok4uw	2877	8	UV	uv	NN
cord-001835-0s7ok4uw	2877	9	CD	cd	NN
cord-001835-0s7ok4uw	2877	10	spectrum	spectrum	NN
cord-001835-0s7ok4uw	2877	11	remained	remain	VBD
cord-001835-0s7ok4uw	2877	12	unchanged	unchanged	JJ
cord-001835-0s7ok4uw	2877	13	,	,	,
cord-001835-0s7ok4uw	2877	14	but	but	CC
cord-001835-0s7ok4uw	2877	15	the	the	DT
cord-001835-0s7ok4uw	2877	16	thermal	thermal	JJ
cord-001835-0s7ok4uw	2877	17	stability	stability	NN
cord-001835-0s7ok4uw	2877	18	increased	increase	VBD
cord-001835-0s7ok4uw	2877	19	by	by	IN
cord-001835-0s7ok4uw	2877	20	approximately	approximately	RB
cord-001835-0s7ok4uw	2877	21	20oC.	20oc.	CD
cord-001835-0s7ok4uw	2877	22	The	the	DT
cord-001835-0s7ok4uw	2877	23	antigen	antigen	NN
cord-001835-0s7ok4uw	2877	24	-	-	HYPH
cord-001835-0s7ok4uw	2877	25	binding	bind	VBG
cord-001835-0s7ok4uw	2877	26	function	function	NN
cord-001835-0s7ok4uw	2877	27	of	of	IN
cord-001835-0s7ok4uw	2877	28	C6	C6	NNP
cord-001835-0s7ok4uw	2877	29	scFv	scFv	NNPS
cord-001835-0s7ok4uw	2877	30	was	be	VBD
cord-001835-0s7ok4uw	2877	31	analyzed	analyze	VBN
cord-001835-0s7ok4uw	2877	32	using	use	VBG
cord-001835-0s7ok4uw	2877	33	a	a	DT
cord-001835-0s7ok4uw	2877	34	surface	surface	NN
cord-001835-0s7ok4uw	2877	35	plasmon	plasmon	NN
cord-001835-0s7ok4uw	2877	36	resonance	resonance	NN
cord-001835-0s7ok4uw	2877	37	(	(	-LRB-
cord-001835-0s7ok4uw	2877	38	SPR	SPR	NNP
cord-001835-0s7ok4uw	2877	39	)	)	-RRB-
cord-001835-0s7ok4uw	2877	40	biosensor	biosensor	NN
cord-001835-0s7ok4uw	2877	41	,	,	,
cord-001835-0s7ok4uw	2877	42	Biacore	Biacore	NNP
cord-001835-0s7ok4uw	2877	43	.	.	.
cord-001835-0s7ok4uw	2878	1	The	the	DT
cord-001835-0s7ok4uw	2878	2	binding	bind	VBG
cord-001835-0s7ok4uw	2878	3	affinity	affinity	NN
cord-001835-0s7ok4uw	2878	4	and	and	CC
cord-001835-0s7ok4uw	2878	5	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	2878	6	of	of	IN
cord-001835-0s7ok4uw	2878	7	C6	C6	NNP
cord-001835-0s7ok4uw	2878	8	scFv	scFv	NNS
cord-001835-0s7ok4uw	2878	9	for	for	IN
cord-001835-0s7ok4uw	2878	10	NP	NP	NNP
cord-001835-0s7ok4uw	2878	11	conjugated	conjugate	VBN
cord-001835-0s7ok4uw	2878	12	to	to	IN
cord-001835-0s7ok4uw	2878	13	bovine	bovine	JJ
cord-001835-0s7ok4uw	2878	14	serum	serum	NN
cord-001835-0s7ok4uw	2878	15	albumin	albumin	NN
cord-001835-0s7ok4uw	2878	16	immobilized	immobilize	VBN
cord-001835-0s7ok4uw	2878	17	on	on	IN
cord-001835-0s7ok4uw	2878	18	the	the	DT
cord-001835-0s7ok4uw	2878	19	sensor	sensor	NN
cord-001835-0s7ok4uw	2878	20	chip	chip	NN
cord-001835-0s7ok4uw	2878	21	were	be	VBD
cord-001835-0s7ok4uw	2878	22	similar	similar	JJ
cord-001835-0s7ok4uw	2878	23	to	to	IN
cord-001835-0s7ok4uw	2878	24	those	those	DT
cord-001835-0s7ok4uw	2878	25	of	of	IN
cord-001835-0s7ok4uw	2878	26	intact	intact	JJ
cord-001835-0s7ok4uw	2878	27	C6	c6	NN
cord-001835-0s7ok4uw	2878	28	.	.	.
cord-001835-0s7ok4uw	2879	1	Taken	take	VBN
cord-001835-0s7ok4uw	2879	2	together	together	RB
cord-001835-0s7ok4uw	2879	3	,	,	,
cord-001835-0s7ok4uw	2879	4	the	the	DT
cord-001835-0s7ok4uw	2879	5	results	result	NNS
cord-001835-0s7ok4uw	2879	6	of	of	IN
cord-001835-0s7ok4uw	2879	7	AUC	AUC	NNP
cord-001835-0s7ok4uw	2879	8	,	,	,
cord-001835-0s7ok4uw	2879	9	CD	CD	NNP
cord-001835-0s7ok4uw	2879	10	,	,	,
cord-001835-0s7ok4uw	2879	11	and	and	CC
cord-001835-0s7ok4uw	2879	12	SPR	SPR	NNP
cord-001835-0s7ok4uw	2879	13	indicated	indicate	VBD
cord-001835-0s7ok4uw	2879	14	that	that	IN
cord-001835-0s7ok4uw	2879	15	C6	c6	NN
cord-001835-0s7ok4uw	2879	16	scFv	scFv	NNP
cord-001835-0s7ok4uw	2879	17	could	could	MD
cord-001835-0s7ok4uw	2879	18	be	be	VB
cord-001835-0s7ok4uw	2879	19	refolded	refolde	VBN
cord-001835-0s7ok4uw	2879	20	successfully	successfully	RB
cord-001835-0s7ok4uw	2879	21	and	and	CC
cord-001835-0s7ok4uw	2879	22	would	would	MD
cord-001835-0s7ok4uw	2879	23	possess	possess	VB
cord-001835-0s7ok4uw	2879	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2879	25	functional	functional	JJ
cord-001835-0s7ok4uw	2879	26	structure	structure	NN
cord-001835-0s7ok4uw	2879	27	.	.	.
cord-001835-0s7ok4uw	2880	1	Next	next	RB
cord-001835-0s7ok4uw	2880	2	,	,	,
cord-001835-0s7ok4uw	2880	3	to	to	TO
cord-001835-0s7ok4uw	2880	4	analyze	analyze	VB
cord-001835-0s7ok4uw	2880	5	the	the	DT
cord-001835-0s7ok4uw	2880	6	structural	structural	JJ
cord-001835-0s7ok4uw	2880	7	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2880	8	of	of	IN
cord-001835-0s7ok4uw	2880	9	C6	C6	NNP
cord-001835-0s7ok4uw	2880	10	scFv	scFv	NNS
cord-001835-0s7ok4uw	2880	11	in	in	IN
cord-001835-0s7ok4uw	2880	12	the	the	DT
cord-001835-0s7ok4uw	2880	13	absence	absence	NN
cord-001835-0s7ok4uw	2880	14	or	or	CC
cord-001835-0s7ok4uw	2880	15	presence	presence	NN
cord-001835-0s7ok4uw	2880	16	of	of	IN
cord-001835-0s7ok4uw	2880	17	antigen	antigen	NN
cord-001835-0s7ok4uw	2880	18	,	,	,
cord-001835-0s7ok4uw	2880	19	experiments	experiment	NNS
cord-001835-0s7ok4uw	2880	20	involving	involve	VBG
cord-001835-0s7ok4uw	2880	21	diffracted	diffracted	JJ
cord-001835-0s7ok4uw	2880	22	X	x	NN
cord-001835-0s7ok4uw	2880	23	-	-	NN
cord-001835-0s7ok4uw	2880	24	ray	ray	NN
cord-001835-0s7ok4uw	2880	25	tracking	tracking	NN
cord-001835-0s7ok4uw	2880	26	(	(	-LRB-
cord-001835-0s7ok4uw	2880	27	DXT	DXT	NNP
cord-001835-0s7ok4uw	2880	28	)	)	-RRB-
cord-001835-0s7ok4uw	2880	29	were	be	VBD
cord-001835-0s7ok4uw	2880	30	performed	perform	VBN
cord-001835-0s7ok4uw	2880	31	[	[	-LRB-
cord-001835-0s7ok4uw	2880	32	4	4	CD
cord-001835-0s7ok4uw	2880	33	]	]	-RRB-
cord-001835-0s7ok4uw	2880	34	.	.	.
cord-001835-0s7ok4uw	2881	1	C6	C6	NNP
cord-001835-0s7ok4uw	2881	2	scFv	scFv	NNP
cord-001835-0s7ok4uw	2881	3	with	with	IN
cord-001835-0s7ok4uw	2881	4	an	an	DT
cord-001835-0s7ok4uw	2881	5	N	n	CD
cord-001835-0s7ok4uw	2881	6	-	-	HYPH
cord-001835-0s7ok4uw	2881	7	terminal	terminal	NN
cord-001835-0s7ok4uw	2881	8	His	-PRON-	PRP$
cord-001835-0s7ok4uw	2881	9	-	-	HYPH
cord-001835-0s7ok4uw	2881	10	tag	tag	NN
cord-001835-0s7ok4uw	2881	11	was	be	VBD
cord-001835-0s7ok4uw	2881	12	immobilized	immobilize	VBN
cord-001835-0s7ok4uw	2881	13	on	on	IN
cord-001835-0s7ok4uw	2881	14	substrate	substrate	NN
cord-001835-0s7ok4uw	2881	15	surfaces	surface	NNS
cord-001835-0s7ok4uw	2881	16	using	use	VBG
cord-001835-0s7ok4uw	2881	17	tag	tag	NN
cord-001835-0s7ok4uw	2881	18	chemistry	chemistry	NN
cord-001835-0s7ok4uw	2881	19	,	,	,
cord-001835-0s7ok4uw	2881	20	and	and	CC
cord-001835-0s7ok4uw	2881	21	Au	Au	NNS
cord-001835-0s7ok4uw	2881	22	-	-	HYPH
cord-001835-0s7ok4uw	2881	23	nanocrystals	nanocrystal	NNS
cord-001835-0s7ok4uw	2881	24	were	be	VBD
cord-001835-0s7ok4uw	2881	25	labeled	label	VBN
cord-001835-0s7ok4uw	2881	26	on	on	IN
cord-001835-0s7ok4uw	2881	27	the	the	DT
cord-001835-0s7ok4uw	2881	28	surface	surface	NN
cord-001835-0s7ok4uw	2881	29	of	of	IN
cord-001835-0s7ok4uw	2881	30	scFv	scFv	NNP
cord-001835-0s7ok4uw	2881	31	as	as	IN
cord-001835-0s7ok4uw	2881	32	tracers	tracer	NNS
cord-001835-0s7ok4uw	2881	33	.	.	.
cord-001835-0s7ok4uw	2882	1	The	the	DT
cord-001835-0s7ok4uw	2882	2	motions	motion	NNS
cord-001835-0s7ok4uw	2882	3	of	of	IN
cord-001835-0s7ok4uw	2882	4	C6	c6	NN
cord-001835-0s7ok4uw	2882	5	scFv	scFv	NNS
cord-001835-0s7ok4uw	2882	6	were	be	VBD
cord-001835-0s7ok4uw	2882	7	analyzed	analyze	VBN
cord-001835-0s7ok4uw	2882	8	in	in	IN
cord-001835-0s7ok4uw	2882	9	two	two	CD
cord-001835-0s7ok4uw	2882	10	rotational	rotational	JJ
cord-001835-0s7ok4uw	2882	11	directions	direction	NNS
cord-001835-0s7ok4uw	2882	12	representing	represent	VBG
cord-001835-0s7ok4uw	2882	13	tilting	tilt	VBG
cord-001835-0s7ok4uw	2882	14	(	(	-LRB-
cord-001835-0s7ok4uw	2882	15	u	u	NN
cord-001835-0s7ok4uw	2882	16	)	)	-RRB-
cord-001835-0s7ok4uw	2882	17	and	and	CC
cord-001835-0s7ok4uw	2882	18	twisting	twisting	NN
cord-001835-0s7ok4uw	2882	19	(	(	-LRB-
cord-001835-0s7ok4uw	2882	20	v	v	NN
cord-001835-0s7ok4uw	2882	21	)	)	-RRB-
cord-001835-0s7ok4uw	2882	22	Mean	mean	JJ
cord-001835-0s7ok4uw	2882	23	square	square	JJ
cord-001835-0s7ok4uw	2882	24	displacement	displacement	NN
cord-001835-0s7ok4uw	2882	25	(	(	-LRB-
cord-001835-0s7ok4uw	2882	26	MSD	MSD	NNP
cord-001835-0s7ok4uw	2882	27	)	)	-RRB-
cord-001835-0s7ok4uw	2882	28	analysis	analysis	NN
cord-001835-0s7ok4uw	2882	29	from	from	IN
cord-001835-0s7ok4uw	2882	30	more	more	JJR
cord-001835-0s7ok4uw	2882	31	than	than	IN
cord-001835-0s7ok4uw	2882	32	200	200	CD
cord-001835-0s7ok4uw	2882	33	trajectories	trajectory	NNS
cord-001835-0s7ok4uw	2882	34	showed	show	VBD
cord-001835-0s7ok4uw	2882	35	that	that	IN
cord-001835-0s7ok4uw	2882	36	the	the	DT
cord-001835-0s7ok4uw	2882	37	slope	slope	NN
cord-001835-0s7ok4uw	2882	38	for	for	IN
cord-001835-0s7ok4uw	2882	39	C6	C6	NNP
cord-001835-0s7ok4uw	2882	40	scFv	scFv	NNS
cord-001835-0s7ok4uw	2882	41	without	without	IN
cord-001835-0s7ok4uw	2882	42	antigen	antigen	NN
cord-001835-0s7ok4uw	2882	43	,	,	,
cord-001835-0s7ok4uw	2882	44	especially	especially	RB
cord-001835-0s7ok4uw	2882	45	in	in	IN
cord-001835-0s7ok4uw	2882	46	the	the	DT
cord-001835-0s7ok4uw	2882	47	u	u	NNP
cord-001835-0s7ok4uw	2882	48	direction	direction	NN
cord-001835-0s7ok4uw	2882	49	,	,	,
cord-001835-0s7ok4uw	2882	50	was	be	VBD
cord-001835-0s7ok4uw	2882	51	greater	great	JJR
cord-001835-0s7ok4uw	2882	52	than	than	IN
cord-001835-0s7ok4uw	2882	53	that	that	DT
cord-001835-0s7ok4uw	2882	54	for	for	IN
cord-001835-0s7ok4uw	2882	55	C6	C6	NNP
cord-001835-0s7ok4uw	2882	56	scFv	scFv	NNP
cord-001835-0s7ok4uw	2882	57	with	with	IN
cord-001835-0s7ok4uw	2882	58	antigen	antigen	NN
cord-001835-0s7ok4uw	2882	59	,	,	,
cord-001835-0s7ok4uw	2882	60	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2882	61	that	that	IN
cord-001835-0s7ok4uw	2882	62	the	the	DT
cord-001835-0s7ok4uw	2882	63	motion	motion	NN
cord-001835-0s7ok4uw	2882	64	of	of	IN
cord-001835-0s7ok4uw	2882	65	scFv	scFv	NNP
cord-001835-0s7ok4uw	2882	66	was	be	VBD
cord-001835-0s7ok4uw	2882	67	suppressed	suppress	VBN
cord-001835-0s7ok4uw	2882	68	on	on	IN
cord-001835-0s7ok4uw	2882	69	antigen	antigen	NN
cord-001835-0s7ok4uw	2882	70	binding	binding	NN
cord-001835-0s7ok4uw	2882	71	.	.	.
cord-001835-0s7ok4uw	2882	72	 	 	_SP
cord-001835-0s7ok4uw	2883	1	The	the	DT
cord-001835-0s7ok4uw	2883	2	antibiotic	antibiotic	JJ
cord-001835-0s7ok4uw	2883	3	resistance	resistance	NN
cord-001835-0s7ok4uw	2883	4	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2883	5	APH(2'')-Ia	aph(2'')-ia	NN
cord-001835-0s7ok4uw	2883	6	confers	confer	VBZ
cord-001835-0s7ok4uw	2883	7	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	2883	8	resistance	resistance	NN
cord-001835-0s7ok4uw	2883	9	to	to	TO
cord-001835-0s7ok4uw	2883	10	aminoglycoside	aminoglycoside	VB
cord-001835-0s7ok4uw	2883	11	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	2883	12	in	in	IN
cord-001835-0s7ok4uw	2883	13	staphylococci	staphylococcus	NNS
cord-001835-0s7ok4uw	2883	14	and	and	CC
cord-001835-0s7ok4uw	2883	15	enterococci	enterococci	NNS
cord-001835-0s7ok4uw	2883	16	.	.	.
cord-001835-0s7ok4uw	2884	1	This	this	DT
cord-001835-0s7ok4uw	2884	2	kinase	kinase	NN
cord-001835-0s7ok4uw	2884	3	phosphorylates	phosphorylate	VBZ
cord-001835-0s7ok4uw	2884	4	aminoglycosides	aminoglycoside	NNS
cord-001835-0s7ok4uw	2884	5	such	such	JJ
cord-001835-0s7ok4uw	2884	6	as	as	IN
cord-001835-0s7ok4uw	2884	7	gentamicin	gentamicin	NNP
cord-001835-0s7ok4uw	2884	8	and	and	CC
cord-001835-0s7ok4uw	2884	9	kanamycin	kanamycin	NNP
cord-001835-0s7ok4uw	2884	10	,	,	,
cord-001835-0s7ok4uw	2884	11	chemically	chemically	RB
cord-001835-0s7ok4uw	2884	12	inactivating	inactivate	VBG
cord-001835-0s7ok4uw	2884	13	the	the	DT
cord-001835-0s7ok4uw	2884	14	compounds	compound	NNS
cord-001835-0s7ok4uw	2884	15	.	.	.
cord-001835-0s7ok4uw	2885	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2885	2	have	have	VBP
cord-001835-0s7ok4uw	2885	3	determined	determine	VBN
cord-001835-0s7ok4uw	2885	4	multiple	multiple	JJ
cord-001835-0s7ok4uw	2885	5	structures	structure	NNS
cord-001835-0s7ok4uw	2885	6	of	of	IN
cord-001835-0s7ok4uw	2885	7	the	the	DT
cord-001835-0s7ok4uw	2885	8	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2885	9	in	in	IN
cord-001835-0s7ok4uw	2885	10	complex	complex	NN
cord-001835-0s7ok4uw	2885	11	with	with	IN
cord-001835-0s7ok4uw	2885	12	nucleoside	nucleoside	NN
cord-001835-0s7ok4uw	2885	13	and	and	CC
cord-001835-0s7ok4uw	2885	14	aminoglycoside	aminoglycoside	NN
cord-001835-0s7ok4uw	2885	15	substrates	substrate	NNS
cord-001835-0s7ok4uw	2885	16	and	and	CC
cord-001835-0s7ok4uw	2885	17	cofactor	cofactor	NN
cord-001835-0s7ok4uw	2885	18	magnesium	magnesium	NN
cord-001835-0s7ok4uw	2885	19	.	.	.
cord-001835-0s7ok4uw	2886	1	Introduction	introduction	NN
cord-001835-0s7ok4uw	2886	2	of	of	IN
cord-001835-0s7ok4uw	2886	3	aminoglycoside	aminoglycoside	NNP
cord-001835-0s7ok4uw	2886	4	to	to	IN
cord-001835-0s7ok4uw	2886	5	crystals	crystal	NNS
cord-001835-0s7ok4uw	2886	6	of	of	IN
cord-001835-0s7ok4uw	2886	7	APH(2'')-Ia	APH(2'')-Ia	NNS
cord-001835-0s7ok4uw	2886	8	induce	induce	VBP
cord-001835-0s7ok4uw	2886	9	gross	gross	JJ
cord-001835-0s7ok4uw	2886	10	conformational	conformational	JJ
cord-001835-0s7ok4uw	2886	11	changes	change	NNS
cord-001835-0s7ok4uw	2886	12	in	in	IN
cord-001835-0s7ok4uw	2886	13	crystallo	crystallo	NNP
cord-001835-0s7ok4uw	2886	14	,	,	,
cord-001835-0s7ok4uw	2886	15	illustrating	illustrate	VBG
cord-001835-0s7ok4uw	2886	16	several	several	JJ
cord-001835-0s7ok4uw	2886	17	important	important	JJ
cord-001835-0s7ok4uw	2886	18	stages	stage	NNS
cord-001835-0s7ok4uw	2886	19	of	of	IN
cord-001835-0s7ok4uw	2886	20	the	the	DT
cord-001835-0s7ok4uw	2886	21	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2886	22	cycle	cycle	NN
cord-001835-0s7ok4uw	2886	23	of	of	IN
cord-001835-0s7ok4uw	2886	24	the	the	DT
cord-001835-0s7ok4uw	2886	25	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2886	26	.	.	.
cord-001835-0s7ok4uw	2887	1	An	an	DT
cord-001835-0s7ok4uw	2887	2	interaction	interaction	NN
cord-001835-0s7ok4uw	2887	3	between	between	IN
cord-001835-0s7ok4uw	2887	4	nucleoside	nucleoside	NN
cord-001835-0s7ok4uw	2887	5	triphosphate	triphosphate	NN
cord-001835-0s7ok4uw	2887	6	and	and	CC
cord-001835-0s7ok4uw	2887	7	an	an	DT
cord-001835-0s7ok4uw	2887	8	amino	amino	NN
cord-001835-0s7ok4uw	2887	9	acid	acid	NN
cord-001835-0s7ok4uw	2887	10	residue	residue	NN
cord-001835-0s7ok4uw	2887	11	on	on	IN
cord-001835-0s7ok4uw	2887	12	a	a	DT
cord-001835-0s7ok4uw	2887	13	conserved	conserved	JJ
cord-001835-0s7ok4uw	2887	14	loop	loop	NN
cord-001835-0s7ok4uw	2887	15	has	have	VBZ
cord-001835-0s7ok4uw	2887	16	also	also	RB
cord-001835-0s7ok4uw	2887	17	been	be	VBN
cord-001835-0s7ok4uw	2887	18	identified	identify	VBN
cord-001835-0s7ok4uw	2887	19	that	that	WDT
cord-001835-0s7ok4uw	2887	20	appears	appear	VBZ
cord-001835-0s7ok4uw	2887	21	to	to	TO
cord-001835-0s7ok4uw	2887	22	govern	govern	VB
cord-001835-0s7ok4uw	2887	23	a	a	DT
cord-001835-0s7ok4uw	2887	24	conformational	conformational	JJ
cord-001835-0s7ok4uw	2887	25	selectivity	selectivity	NN
cord-001835-0s7ok4uw	2887	26	and	and	CC
cord-001835-0s7ok4uw	2887	27	modulates	modulate	VBZ
cord-001835-0s7ok4uw	2887	28	the	the	DT
cord-001835-0s7ok4uw	2887	29	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2887	30	activity	activity	NN
cord-001835-0s7ok4uw	2887	31	when	when	WRB
cord-001835-0s7ok4uw	2887	32	no	no	DT
cord-001835-0s7ok4uw	2887	33	substrate	substrate	NN
cord-001835-0s7ok4uw	2887	34	is	be	VBZ
cord-001835-0s7ok4uw	2887	35	present	present	JJ
cord-001835-0s7ok4uw	2887	36	.	.	.
cord-001835-0s7ok4uw	2888	1	Comparisons	comparison	NNS
cord-001835-0s7ok4uw	2888	2	between	between	IN
cord-001835-0s7ok4uw	2888	3	multiple	multiple	JJ
cord-001835-0s7ok4uw	2888	4	protein	protein	NN
cord-001835-0s7ok4uw	2888	5	molecules	molecule	NNS
cord-001835-0s7ok4uw	2888	6	both	both	CC
cord-001835-0s7ok4uw	2888	7	within	within	IN
cord-001835-0s7ok4uw	2888	8	and	and	CC
cord-001835-0s7ok4uw	2888	9	between	between	IN
cord-001835-0s7ok4uw	2888	10	crystal	crystal	JJ
cord-001835-0s7ok4uw	2888	11	structures	structure	NNS
cord-001835-0s7ok4uw	2888	12	allow	allow	VBP
cord-001835-0s7ok4uw	2888	13	us	-PRON-	PRP
cord-001835-0s7ok4uw	2888	14	to	to	TO
cord-001835-0s7ok4uw	2888	15	infer	infer	VB
cord-001835-0s7ok4uw	2888	16	functional	functional	JJ
cord-001835-0s7ok4uw	2888	17	states	state	NNS
cord-001835-0s7ok4uw	2888	18	of	of	IN
cord-001835-0s7ok4uw	2888	19	the	the	DT
cord-001835-0s7ok4uw	2888	20	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2888	21	as	as	IN
cord-001835-0s7ok4uw	2888	22	it	-PRON-	PRP
cord-001835-0s7ok4uw	2888	23	carries	carry	VBZ
cord-001835-0s7ok4uw	2888	24	out	out	RP
cord-001835-0s7ok4uw	2888	25	catalysis	catalysis	NN
cord-001835-0s7ok4uw	2888	26	.	.	.
cord-001835-0s7ok4uw	2889	1	These	these	DT
cord-001835-0s7ok4uw	2889	2	structures	structure	NNS
cord-001835-0s7ok4uw	2889	3	collectively	collectively	RB
cord-001835-0s7ok4uw	2889	4	highlight	highlight	VBP
cord-001835-0s7ok4uw	2889	5	an	an	DT
cord-001835-0s7ok4uw	2889	6	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	2889	7	flexibility	flexibility	NN
cord-001835-0s7ok4uw	2889	8	that	that	WDT
cord-001835-0s7ok4uw	2889	9	not	not	RB
cord-001835-0s7ok4uw	2889	10	only	only	RB
cord-001835-0s7ok4uw	2889	11	allows	allow	VBZ
cord-001835-0s7ok4uw	2889	12	the	the	DT
cord-001835-0s7ok4uw	2889	13	binding	binding	NN
cord-001835-0s7ok4uw	2889	14	of	of	IN
cord-001835-0s7ok4uw	2889	15	diverse	diverse	JJ
cord-001835-0s7ok4uw	2889	16	aminoglycosides	aminoglycoside	NNS
cord-001835-0s7ok4uw	2889	17	,	,	,
cord-001835-0s7ok4uw	2889	18	but	but	CC
cord-001835-0s7ok4uw	2889	19	also	also	RB
cord-001835-0s7ok4uw	2889	20	appears	appear	VBZ
cord-001835-0s7ok4uw	2889	21	to	to	TO
cord-001835-0s7ok4uw	2889	22	transition	transition	VB
cord-001835-0s7ok4uw	2889	23	from	from	IN
cord-001835-0s7ok4uw	2889	24	a	a	DT
cord-001835-0s7ok4uw	2889	25	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	2889	26	,	,	,
cord-001835-0s7ok4uw	2889	27	inactive	inactive	JJ
cord-001835-0s7ok4uw	2889	28	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	2889	29	state	state	NN
cord-001835-0s7ok4uw	2889	30	to	to	IN
cord-001835-0s7ok4uw	2889	31	a	a	DT
cord-001835-0s7ok4uw	2889	32	catalytically	catalytically	RB
cord-001835-0s7ok4uw	2889	33	active	active	JJ
cord-001835-0s7ok4uw	2889	34	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2889	35	with	with	IN
cord-001835-0s7ok4uw	2889	36	an	an	DT
cord-001835-0s7ok4uw	2889	37	active	active	JJ
cord-001835-0s7ok4uw	2889	38	site	site	NN
cord-001835-0s7ok4uw	2889	39	geometry	geometry	NN
cord-001835-0s7ok4uw	2889	40	identical	identical	JJ
cord-001835-0s7ok4uw	2889	41	to	to	IN
cord-001835-0s7ok4uw	2889	42	distantly	distantly	RB
cord-001835-0s7ok4uw	2889	43	-	-	HYPH
cord-001835-0s7ok4uw	2889	44	related	relate	VBN
cord-001835-0s7ok4uw	2889	45	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	2889	46	protein	protein	NN
cord-001835-0s7ok4uw	2889	47	kinases	kinase	NNS
cord-001835-0s7ok4uw	2889	48	.	.	.
cord-001835-0s7ok4uw	2890	1	Mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	2890	2	insight	insight	NN
cord-001835-0s7ok4uw	2890	3	gained	gain	VBD
cord-001835-0s7ok4uw	2890	4	from	from	IN
cord-001835-0s7ok4uw	2890	5	these	these	DT
cord-001835-0s7ok4uw	2890	6	studies	study	NNS
cord-001835-0s7ok4uw	2890	7	begin	begin	VBP
cord-001835-0s7ok4uw	2890	8	to	to	TO
cord-001835-0s7ok4uw	2890	9	demystify	demystify	VB
cord-001835-0s7ok4uw	2890	10	a	a	DT
cord-001835-0s7ok4uw	2890	11	widespread	widespread	JJ
cord-001835-0s7ok4uw	2890	12	staphylococcal	staphylococcal	JJ
cord-001835-0s7ok4uw	2890	13	resistance	resistance	NN
cord-001835-0s7ok4uw	2890	14	factor	factor	NN
cord-001835-0s7ok4uw	2890	15	,	,	,
cord-001835-0s7ok4uw	2890	16	and	and	CC
cord-001835-0s7ok4uw	2890	17	provide	provide	VB
cord-001835-0s7ok4uw	2890	18	a	a	DT
cord-001835-0s7ok4uw	2890	19	starting	starting	NN
cord-001835-0s7ok4uw	2890	20	point	point	NN
cord-001835-0s7ok4uw	2890	21	for	for	IN
cord-001835-0s7ok4uw	2890	22	the	the	DT
cord-001835-0s7ok4uw	2890	23	development	development	NN
cord-001835-0s7ok4uw	2890	24	of	of	IN
cord-001835-0s7ok4uw	2890	25	anti	anti	JJ
cord-001835-0s7ok4uw	2890	26	-	-	JJ
cord-001835-0s7ok4uw	2890	27	infectives	infective	NNS
cord-001835-0s7ok4uw	2890	28	toward	toward	IN
cord-001835-0s7ok4uw	2890	29	this	this	DT
cord-001835-0s7ok4uw	2890	30	important	important	JJ
cord-001835-0s7ok4uw	2890	31	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	2890	32	resistance	resistance	NN
cord-001835-0s7ok4uw	2890	33	machine	machine	NN
cord-001835-0s7ok4uw	2890	34	.	.	.
cord-001835-0s7ok4uw	2891	1	Ryan	Ryan	NNP
cord-001835-0s7ok4uw	2891	2	Godwin	Godwin	NNP
cord-001835-0s7ok4uw	2891	3	1	1	CD
cord-001835-0s7ok4uw	2891	4	,	,	,
cord-001835-0s7ok4uw	2891	5	William	William	NNP
cord-001835-0s7ok4uw	2891	6	Gmeiner	Gmeiner	NNP
cord-001835-0s7ok4uw	2891	7	2	2	CD
cord-001835-0s7ok4uw	2891	8	,	,	,
cord-001835-0s7ok4uw	2891	9	Freddie	Freddie	NNP
cord-001835-0s7ok4uw	2891	10	Salsbury	Salsbury	NNP
cord-001835-0s7ok4uw	2892	1	1	1	LS
cord-001835-0s7ok4uw	2892	2	1	1	CD
cord-001835-0s7ok4uw	2892	3	Wake	Wake	NNP
cord-001835-0s7ok4uw	2892	4	Forest	Forest	NNP
cord-001835-0s7ok4uw	2892	5	University	University	NNP
cord-001835-0s7ok4uw	2892	6	-Department	-department	NN
cord-001835-0s7ok4uw	2892	7	of	of	IN
cord-001835-0s7ok4uw	2892	8	Physics	Physics	NNP
cord-001835-0s7ok4uw	2892	9	,	,	,
cord-001835-0s7ok4uw	2892	10	2	2	CD
cord-001835-0s7ok4uw	2892	11	Wake	Wake	NNP
cord-001835-0s7ok4uw	2892	12	Forest	Forest	NNP
cord-001835-0s7ok4uw	2892	13	University	University	NNP
cord-001835-0s7ok4uw	2892	14	Health	Health	NNP
cord-001835-0s7ok4uw	2892	15	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	2892	16	-Department	-department	NN
cord-001835-0s7ok4uw	2892	17	of	of	IN
cord-001835-0s7ok4uw	2892	18	Cancer	Cancer	NNP
cord-001835-0s7ok4uw	2892	19	Biology	Biology	NNP
cord-001835-0s7ok4uw	2893	1	The	the	DT
cord-001835-0s7ok4uw	2893	2	zinc	zinc	NN
cord-001835-0s7ok4uw	2893	3	-	-	HYPH
cord-001835-0s7ok4uw	2893	4	finger	finger	NN
cord-001835-0s7ok4uw	2893	5	of	of	IN
cord-001835-0s7ok4uw	2893	6	the	the	DT
cord-001835-0s7ok4uw	2893	7	NF	nf	NN
cord-001835-0s7ok4uw	2893	8	-	-	HYPH
cord-001835-0s7ok4uw	2893	9	jB	jB	NNP
cord-001835-0s7ok4uw	2893	10	Essential	Essential	NNP
cord-001835-0s7ok4uw	2893	11	Modulator	Modulator	NNP
cord-001835-0s7ok4uw	2893	12	(	(	-LRB-
cord-001835-0s7ok4uw	2893	13	NEMO	NEMO	NNP
cord-001835-0s7ok4uw	2893	14	)	)	-RRB-
cord-001835-0s7ok4uw	2893	15	is	be	VBZ
cord-001835-0s7ok4uw	2893	16	a	a	DT
cord-001835-0s7ok4uw	2893	17	ubiquitin	ubiquitin	JJ
cord-001835-0s7ok4uw	2893	18	binding	binding	NN
cord-001835-0s7ok4uw	2893	19	domain	domain	NN
cord-001835-0s7ok4uw	2893	20	,	,	,
cord-001835-0s7ok4uw	2893	21	and	and	CC
cord-001835-0s7ok4uw	2893	22	an	an	DT
cord-001835-0s7ok4uw	2893	23	important	important	JJ
cord-001835-0s7ok4uw	2893	24	regulator	regulator	NN
cord-001835-0s7ok4uw	2893	25	of	of	IN
cord-001835-0s7ok4uw	2893	26	various	various	JJ
cord-001835-0s7ok4uw	2893	27	physiological	physiological	JJ
cord-001835-0s7ok4uw	2893	28	processes	process	NNS
cord-001835-0s7ok4uw	2893	29	including	include	VBG
cord-001835-0s7ok4uw	2893	30	immune	immune	JJ
cord-001835-0s7ok4uw	2893	31	/	/	SYM
cord-001835-0s7ok4uw	2893	32	inflammatory	inflammatory	JJ
cord-001835-0s7ok4uw	2893	33	responses	response	NNS
cord-001835-0s7ok4uw	2893	34	,	,	,
cord-001835-0s7ok4uw	2893	35	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	2893	36	,	,	,
cord-001835-0s7ok4uw	2893	37	and	and	CC
cord-001835-0s7ok4uw	2893	38	oncogenesis	oncogenesis	NN
cord-001835-0s7ok4uw	2893	39	.	.	.
cord-001835-0s7ok4uw	2894	1	The	the	DT
cord-001835-0s7ok4uw	2894	2	nominally	nominally	RB
cord-001835-0s7ok4uw	2894	3	functioning	function	VBG
cord-001835-0s7ok4uw	2894	4	28	28	CD
cord-001835-0s7ok4uw	2894	5	residue	residue	NN
cord-001835-0s7ok4uw	2894	6	monomer	monomer	NN
cord-001835-0s7ok4uw	2894	7	(	(	-LRB-
cord-001835-0s7ok4uw	2894	8	2JVX	2JVX	NNP
cord-001835-0s7ok4uw	2894	9	)	)	-RRB-
cord-001835-0s7ok4uw	2894	10	is	be	VBZ
cord-001835-0s7ok4uw	2894	11	represented	represent	VBN
cord-001835-0s7ok4uw	2894	12	by	by	IN
cord-001835-0s7ok4uw	2894	13	a	a	DT
cord-001835-0s7ok4uw	2894	14	bba	bba	JJ
cord-001835-0s7ok4uw	2894	15	motif	motif	NN
cord-001835-0s7ok4uw	2894	16	,	,	,
cord-001835-0s7ok4uw	2894	17	with	with	IN
cord-001835-0s7ok4uw	2894	18	a	a	DT
cord-001835-0s7ok4uw	2894	19	CCHC	CCHC	NNP
cord-001835-0s7ok4uw	2894	20	active	active	JJ
cord-001835-0s7ok4uw	2894	21	site	site	NN
cord-001835-0s7ok4uw	2894	22	coordinating	coordinate	VBG
cord-001835-0s7ok4uw	2894	23	the	the	DT
cord-001835-0s7ok4uw	2894	24	zinc	zinc	NN
cord-001835-0s7ok4uw	2894	25	ion	ion	NN
cord-001835-0s7ok4uw	2894	26	.	.	.
cord-001835-0s7ok4uw	2895	1	Here	here	RB
cord-001835-0s7ok4uw	2895	2	,	,	,
cord-001835-0s7ok4uw	2895	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2895	4	investigate	investigate	VBP
cord-001835-0s7ok4uw	2895	5	the	the	DT
cord-001835-0s7ok4uw	2895	6	effects	effect	NNS
cord-001835-0s7ok4uw	2895	7	of	of	IN
cord-001835-0s7ok4uw	2895	8	a	a	DT
cord-001835-0s7ok4uw	2895	9	single	single	JJ
cord-001835-0s7ok4uw	2895	10	point	point	NN
cord-001835-0s7ok4uw	2895	11	mutation	mutation	NN
cord-001835-0s7ok4uw	2895	12	that	that	WDT
cord-001835-0s7ok4uw	2895	13	has	have	VBZ
cord-001835-0s7ok4uw	2895	14	been	be	VBN
cord-001835-0s7ok4uw	2895	15	linked	link	VBN
cord-001835-0s7ok4uw	2895	16	to	to	IN
cord-001835-0s7ok4uw	2895	17	the	the	DT
cord-001835-0s7ok4uw	2895	18	disease	disease	NN
cord-001835-0s7ok4uw	2895	19	states	state	NNS
cord-001835-0s7ok4uw	2895	20	associated	associate	VBN
cord-001835-0s7ok4uw	2895	21	with	with	IN
cord-001835-0s7ok4uw	2895	22	ectodermal	ectodermal	JJ
cord-001835-0s7ok4uw	2895	23	dysplasia	dysplasia	NN
cord-001835-0s7ok4uw	2895	24	.	.	.
cord-001835-0s7ok4uw	2896	1	The	the	DT
cord-001835-0s7ok4uw	2896	2	single	single	JJ
cord-001835-0s7ok4uw	2896	3	mutation	mutation	NN
cord-001835-0s7ok4uw	2896	4	of	of	IN
cord-001835-0s7ok4uw	2896	5	the	the	DT
cord-001835-0s7ok4uw	2896	6	last	last	JJ
cord-001835-0s7ok4uw	2896	7	binding	bind	VBG
cord-001835-0s7ok4uw	2896	8	cysteine	cysteine	NN
cord-001835-0s7ok4uw	2896	9	(	(	-LRB-
cord-001835-0s7ok4uw	2896	10	residue	residue	NN
cord-001835-0s7ok4uw	2896	11	26	26	CD
cord-001835-0s7ok4uw	2896	12	)	)	-RRB-
cord-001835-0s7ok4uw	2896	13	to	to	IN
cord-001835-0s7ok4uw	2896	14	a	a	DT
cord-001835-0s7ok4uw	2896	15	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	2896	16	(	(	-LRB-
cord-001835-0s7ok4uw	2896	17	2JVY	2jvy	LS
cord-001835-0s7ok4uw	2896	18	)	)	-RRB-
cord-001835-0s7ok4uw	2896	19	distorts	distort	VBZ
cord-001835-0s7ok4uw	2896	20	the	the	DT
cord-001835-0s7ok4uw	2896	21	available	available	JJ
cord-001835-0s7ok4uw	2896	22	conformation	conformation	NN
cord-001835-0s7ok4uw	2896	23	and	and	CC
cord-001835-0s7ok4uw	2896	24	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2896	25	of	of	IN
cord-001835-0s7ok4uw	2896	26	the	the	DT
cord-001835-0s7ok4uw	2896	27	protein	protein	NN
cord-001835-0s7ok4uw	2896	28	,	,	,
cord-001835-0s7ok4uw	2896	29	as	as	IN
cord-001835-0s7ok4uw	2896	30	shown	show	VBN
cord-001835-0s7ok4uw	2896	31	via	via	IN
cord-001835-0s7ok4uw	2896	32	microsecond	microsecond	NN
cord-001835-0s7ok4uw	2896	33	,	,	,
cord-001835-0s7ok4uw	2896	34	GPUaccelerated	GPUaccelerated	NNP
cord-001835-0s7ok4uw	2896	35	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	2896	36	Dynamics	Dynamics	NNP
cord-001835-0s7ok4uw	2896	37	simulations	simulation	NNS
cord-001835-0s7ok4uw	2896	38	.	.	.
cord-001835-0s7ok4uw	2897	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2897	2	examine	examine	VBP
cord-001835-0s7ok4uw	2897	3	these	these	DT
cord-001835-0s7ok4uw	2897	4	two	two	CD
cord-001835-0s7ok4uw	2897	5	proteins	protein	NNS
cord-001835-0s7ok4uw	2897	6	in	in	IN
cord-001835-0s7ok4uw	2897	7	various	various	JJ
cord-001835-0s7ok4uw	2897	8	states	state	NNS
cord-001835-0s7ok4uw	2897	9	of	of	IN
cord-001835-0s7ok4uw	2897	10	zinc	zinc	NN
cord-001835-0s7ok4uw	2897	11	-	-	HYPH
cord-001835-0s7ok4uw	2897	12	binding	bind	VBG
cord-001835-0s7ok4uw	2897	13	and	and	CC
cord-001835-0s7ok4uw	2897	14	coordinating	coordinate	VBG
cord-001835-0s7ok4uw	2897	15	cysteine	cysteine	NN
cord-001835-0s7ok4uw	2897	16	protonation	protonation	NN
cord-001835-0s7ok4uw	2897	17	.	.	.
cord-001835-0s7ok4uw	2898	1	In	in	IN
cord-001835-0s7ok4uw	2898	2	addition	addition	NN
cord-001835-0s7ok4uw	2898	3	to	to	IN
cord-001835-0s7ok4uw	2898	4	destabilization	destabilization	NN
cord-001835-0s7ok4uw	2898	5	of	of	IN
cord-001835-0s7ok4uw	2898	6	the	the	DT
cord-001835-0s7ok4uw	2898	7	alphahelix	alphahelix	NNP
cord-001835-0s7ok4uw	2898	8	induced	induce	VBN
cord-001835-0s7ok4uw	2898	9	by	by	IN
cord-001835-0s7ok4uw	2898	10	the	the	DT
cord-001835-0s7ok4uw	2898	11	cysteine	cysteine	NN
cord-001835-0s7ok4uw	2898	12	to	to	IN
cord-001835-0s7ok4uw	2898	13	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	2898	14	mutation	mutation	NN
cord-001835-0s7ok4uw	2898	15	,	,	,
cord-001835-0s7ok4uw	2898	16	prominent	prominent	JJ
cord-001835-0s7ok4uw	2898	17	conformations	conformation	NNS
cord-001835-0s7ok4uw	2898	18	show	show	VBP
cord-001835-0s7ok4uw	2898	19	the	the	DT
cord-001835-0s7ok4uw	2898	20	bsheets	bsheet	NNS
cord-001835-0s7ok4uw	2898	21	turned	turn	VBD
cord-001835-0s7ok4uw	2898	22	perpendicular	perpendicular	RB
cord-001835-0s7ok4uw	2898	23	to	to	IN
cord-001835-0s7ok4uw	2898	24	the	the	DT
cord-001835-0s7ok4uw	2898	25	alpha	alpha	NN
cord-001835-0s7ok4uw	2898	26	-	-	HYPH
cord-001835-0s7ok4uw	2898	27	helix	helix	NN
cord-001835-0s7ok4uw	2898	28	,	,	,
cord-001835-0s7ok4uw	2898	29	providing	provide	VBG
cord-001835-0s7ok4uw	2898	30	a	a	DT
cord-001835-0s7ok4uw	2898	31	possible	possible	JJ
cord-001835-0s7ok4uw	2898	32	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2898	33	for	for	IN
cord-001835-0s7ok4uw	2898	34	the	the	DT
cord-001835-0s7ok4uw	2898	35	induced	induce	VBN
cord-001835-0s7ok4uw	2898	36	disease	disease	NN
cord-001835-0s7ok4uw	2898	37	state	state	NN
cord-001835-0s7ok4uw	2898	38	.	.	.
cord-001835-0s7ok4uw	2899	1	,	,	,
cord-001835-0s7ok4uw	2899	2	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2899	3	(	(	-LRB-
cord-001835-0s7ok4uw	2899	4	51	51	CD
cord-001835-0s7ok4uw	2899	5	-	-	SYM
cord-001835-0s7ok4uw	2899	6	220	220	CD
cord-001835-0s7ok4uw	2899	7	aa	aa	NNP
cord-001835-0s7ok4uw	2899	8	)	)	-RRB-
cord-001835-0s7ok4uw	2899	9	and	and	CC
cord-001835-0s7ok4uw	2899	10	C	C	NNP
cord-001835-0s7ok4uw	2899	11	-	-	HYPH
cord-001835-0s7ok4uw	2899	12	terminal	terminal	NN
cord-001835-0s7ok4uw	2899	13	(	(	-LRB-
cord-001835-0s7ok4uw	2899	14	220	220	CD
cord-001835-0s7ok4uw	2899	15	-	-	SYM
cord-001835-0s7ok4uw	2899	16	270	270	CD
cord-001835-0s7ok4uw	2899	17	aa	aa	NN
cord-001835-0s7ok4uw	2899	18	)	)	-RRB-
cord-001835-0s7ok4uw	2899	19	)	)	-RRB-
cord-001835-0s7ok4uw	2899	20	were	be	VBD
cord-001835-0s7ok4uw	2899	21	expressed	express	VBN
cord-001835-0s7ok4uw	2899	22	in	in	IN
cord-001835-0s7ok4uw	2899	23	E.	E.	NNP
cord-001835-0s7ok4uw	2899	24	coli	coli	NNS
cord-001835-0s7ok4uw	2899	25	.	.	.
cord-001835-0s7ok4uw	2900	1	Several	several	JJ
cord-001835-0s7ok4uw	2900	2	truncated	truncate	VBN
cord-001835-0s7ok4uw	2900	3	IN	in	IN
cord-001835-0s7ok4uw	2900	4	variants	variant	NNS
cord-001835-0s7ok4uw	2900	5	containing	contain	VBG
cord-001835-0s7ok4uw	2900	6	amino	amino	JJ
cord-001835-0s7ok4uw	2900	7	acids	acid	NNS
cord-001835-0s7ok4uw	2900	8	1	1	CD
cord-001835-0s7ok4uw	2900	9	-	-	SYM
cord-001835-0s7ok4uw	2900	10	160	160	CD
cord-001835-0s7ok4uw	2900	11	,	,	,
cord-001835-0s7ok4uw	2900	12	1	1	CD
cord-001835-0s7ok4uw	2900	13	-	-	SYM
cord-001835-0s7ok4uw	2900	14	220	220	CD
cord-001835-0s7ok4uw	2900	15	,	,	,
cord-001835-0s7ok4uw	2900	16	51	51	CD
cord-001835-0s7ok4uw	2900	17	-	-	SYM
cord-001835-0s7ok4uw	2900	18	160	160	CD
cord-001835-0s7ok4uw	2900	19	and	and	CC
cord-001835-0s7ok4uw	2900	20	51	51	CD
cord-001835-0s7ok4uw	2900	21	-	-	SYM
cord-001835-0s7ok4uw	2900	22	280	280	CD
cord-001835-0s7ok4uw	2900	23	were	be	VBD
cord-001835-0s7ok4uw	2900	24	also	also	RB
cord-001835-0s7ok4uw	2900	25	prepared	prepare	VBN
cord-001835-0s7ok4uw	2900	26	.	.	.
cord-001835-0s7ok4uw	2901	1	A	a	DT
cord-001835-0s7ok4uw	2901	2	full	full	JJ
cord-001835-0s7ok4uw	2901	3	-	-	HYPH
cord-001835-0s7ok4uw	2901	4	size	size	NN
cord-001835-0s7ok4uw	2901	5	Ku70	Ku70	NNP
cord-001835-0s7ok4uw	2901	6	with	with	IN
cord-001835-0s7ok4uw	2901	7	a	a	DT
cord-001835-0s7ok4uw	2901	8	GST	gst	NN
cord-001835-0s7ok4uw	2901	9	-	-	HYPH
cord-001835-0s7ok4uw	2901	10	tag	tag	NN
cord-001835-0s7ok4uw	2901	11	on	on	IN
cord-001835-0s7ok4uw	2901	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2901	13	N	n	CD
cord-001835-0s7ok4uw	2901	14	-	-	HYPH
cord-001835-0s7ok4uw	2901	15	terminus	terminus	NN
cord-001835-0s7ok4uw	2901	16	was	be	VBD
cord-001835-0s7ok4uw	2901	17	purified	purify	VBN
cord-001835-0s7ok4uw	2901	18	from	from	IN
cord-001835-0s7ok4uw	2901	19	E.	E.	NNP
cord-001835-0s7ok4uw	2901	20	coli	coli	NNS
cord-001835-0s7ok4uw	2901	21	.	.	.
cord-001835-0s7ok4uw	2902	1	All	all	PDT
cord-001835-0s7ok4uw	2902	2	the	the	DT
cord-001835-0s7ok4uw	2902	3	experiments	experiment	NNS
cord-001835-0s7ok4uw	2902	4	performed	perform	VBN
cord-001835-0s7ok4uw	2902	5	showed	show	VBD
cord-001835-0s7ok4uw	2902	6	that	that	IN
cord-001835-0s7ok4uw	2902	7	neither	neither	CC
cord-001835-0s7ok4uw	2902	8	N	n	CD
cord-001835-0s7ok4uw	2902	9	-	-	HYPH
cord-001835-0s7ok4uw	2902	10	terminal	terminal	NN
cord-001835-0s7ok4uw	2902	11	nor	nor	CC
cord-001835-0s7ok4uw	2902	12	C	c	NN
cord-001835-0s7ok4uw	2902	13	-	-	HYPH
cord-001835-0s7ok4uw	2902	14	terminal	terminal	NN
cord-001835-0s7ok4uw	2902	15	domains	domain	NNS
cord-001835-0s7ok4uw	2902	16	of	of	IN
cord-001835-0s7ok4uw	2902	17	HIV-1	HIV-1	NNP
cord-001835-0s7ok4uw	2902	18	IN	in	IN
cord-001835-0s7ok4uw	2902	19	are	be	VBP
cord-001835-0s7ok4uw	2902	20	essential	essential	JJ
cord-001835-0s7ok4uw	2902	21	for	for	IN
cord-001835-0s7ok4uw	2902	22	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2902	23	binding	binding	NN
cord-001835-0s7ok4uw	2902	24	with	with	IN
cord-001835-0s7ok4uw	2902	25	Ku70	Ku70	NNP
cord-001835-0s7ok4uw	2903	1	despite	despite	IN
cord-001835-0s7ok4uw	2903	2	a	a	DT
cord-001835-0s7ok4uw	2903	3	weak	weak	JJ
cord-001835-0s7ok4uw	2903	4	binding	binding	NN
cord-001835-0s7ok4uw	2903	5	capacity	capacity	NN
cord-001835-0s7ok4uw	2903	6	retaining	retain	VBG
cord-001835-0s7ok4uw	2903	7	to	to	IN
cord-001835-0s7ok4uw	2903	8	the	the	DT
cord-001835-0s7ok4uw	2903	9	C	C	NNP
cord-001835-0s7ok4uw	2903	10	-	-	HYPH
cord-001835-0s7ok4uw	2903	11	terminal	terminal	NN
cord-001835-0s7ok4uw	2903	12	domain	domain	NN
cord-001835-0s7ok4uw	2903	13	.	.	.
cord-001835-0s7ok4uw	2904	1	The	the	DT
cord-001835-0s7ok4uw	2904	2	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2904	3	core	core	NN
cord-001835-0s7ok4uw	2904	4	(	(	-LRB-
cord-001835-0s7ok4uw	2904	5	51	51	CD
cord-001835-0s7ok4uw	2904	6	-	-	SYM
cord-001835-0s7ok4uw	2904	7	220	220	CD
cord-001835-0s7ok4uw	2904	8	aa	aa	NNP
cord-001835-0s7ok4uw	2904	9	)	)	-RRB-
cord-001835-0s7ok4uw	2904	10	as	as	RB
cord-001835-0s7ok4uw	2904	11	well	well	RB
cord-001835-0s7ok4uw	2904	12	as	as	IN
cord-001835-0s7ok4uw	2904	13	the	the	DT
cord-001835-0s7ok4uw	2904	14	mutant	mutant	JJ
cord-001835-0s7ok4uw	2904	15	lacking	lack	VBG
cord-001835-0s7ok4uw	2904	16	C	c	NN
cord-001835-0s7ok4uw	2904	17	-	-	HYPH
cord-001835-0s7ok4uw	2904	18	terminal	terminal	NN
cord-001835-0s7ok4uw	2904	19	domain	domain	NN
cord-001835-0s7ok4uw	2904	20	(	(	-LRB-
cord-001835-0s7ok4uw	2904	21	1	1	CD
cord-001835-0s7ok4uw	2904	22	-	-	SYM
cord-001835-0s7ok4uw	2904	23	220	220	CD
cord-001835-0s7ok4uw	2904	24	)	)	-RRB-
cord-001835-0s7ok4uw	2904	25	both	both	DT
cord-001835-0s7ok4uw	2904	26	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	2904	27	affinity	affinity	NN
cord-001835-0s7ok4uw	2904	28	to	to	IN
cord-001835-0s7ok4uw	2904	29	Ku70	Ku70	NNP
cord-001835-0s7ok4uw	2904	30	comparable	comparable	JJ
cord-001835-0s7ok4uw	2904	31	to	to	IN
cord-001835-0s7ok4uw	2904	32	the	the	DT
cord-001835-0s7ok4uw	2904	33	affinity	affinity	NN
cord-001835-0s7ok4uw	2904	34	of	of	IN
cord-001835-0s7ok4uw	2904	35	the	the	DT
cord-001835-0s7ok4uw	2904	36	full	full	JJ
cord-001835-0s7ok4uw	2904	37	-	-	HYPH
cord-001835-0s7ok4uw	2904	38	size	size	NN
cord-001835-0s7ok4uw	2904	39	IN	in	IN
cord-001835-0s7ok4uw	2904	40	,	,	,
cord-001835-0s7ok4uw	2904	41	whereas	whereas	IN
cord-001835-0s7ok4uw	2904	42	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2904	43	truncated	truncated	JJ
cord-001835-0s7ok4uw	2904	44	variant	variant	NN
cord-001835-0s7ok4uw	2904	45	(	(	-LRB-
cord-001835-0s7ok4uw	2904	46	51	51	CD
cord-001835-0s7ok4uw	2904	47	-	-	SYM
cord-001835-0s7ok4uw	2904	48	160	160	CD
cord-001835-0s7ok4uw	2904	49	aa	aa	NN
cord-001835-0s7ok4uw	2904	50	)	)	-RRB-
cord-001835-0s7ok4uw	2904	51	bound	bind	VBN
cord-001835-0s7ok4uw	2904	52	to	to	IN
cord-001835-0s7ok4uw	2904	53	Ku70	Ku70	NNP
cord-001835-0s7ok4uw	2905	1	protein	protein	NN
cord-001835-0s7ok4uw	2905	2	only	only	RB
cord-001835-0s7ok4uw	2905	3	weakly	weakly	RB
cord-001835-0s7ok4uw	2905	4	.	.	.
cord-001835-0s7ok4uw	2906	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2906	2	also	also	RB
cord-001835-0s7ok4uw	2906	3	expressed	express	VBD
cord-001835-0s7ok4uw	2906	4	a	a	DT
cord-001835-0s7ok4uw	2906	5	C	c	NN
cord-001835-0s7ok4uw	2906	6	-	-	HYPH
cord-001835-0s7ok4uw	2906	7	terminal	terminal	NN
cord-001835-0s7ok4uw	2906	8	HA	HA	NNP
cord-001835-0s7ok4uw	2906	9	-	-	HYPH
cord-001835-0s7ok4uw	2906	10	tagged	tag	VBN
cord-001835-0s7ok4uw	2906	11	full	full	JJ
cord-001835-0s7ok4uw	2906	12	-	-	HYPH
cord-001835-0s7ok4uw	2906	13	length	length	NN
cord-001835-0s7ok4uw	2906	14	IN	in	RB
cord-001835-0s7ok4uw	2906	15	and	and	CC
cord-001835-0s7ok4uw	2906	16	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2906	17	1	1	CD
cord-001835-0s7ok4uw	2906	18	-	-	SYM
cord-001835-0s7ok4uw	2906	19	220	220	CD
cord-001835-0s7ok4uw	2906	20	variant	variant	NN
cord-001835-0s7ok4uw	2906	21	in	in	IN
cord-001835-0s7ok4uw	2906	22	HEK	HEK	NNP
cord-001835-0s7ok4uw	2906	23	293	293	CD
cord-001835-0s7ok4uw	2906	24	T	T	NNP
cord-001835-0s7ok4uw	2906	25	cells	cell	NNS
cord-001835-0s7ok4uw	2906	26	together	together	RB
cord-001835-0s7ok4uw	2906	27	with	with	IN
cord-001835-0s7ok4uw	2906	28	a	a	DT
cord-001835-0s7ok4uw	2906	29	WT	wt	NN
cord-001835-0s7ok4uw	2907	1	Ku70	Ku70	NNP
cord-001835-0s7ok4uw	2907	2	-	-	HYPH
cord-001835-0s7ok4uw	2907	3	3FLAG	3FLAG	NNP
cord-001835-0s7ok4uw	2907	4	and	and	CC
cord-001835-0s7ok4uw	2907	5	showed	show	VBD
cord-001835-0s7ok4uw	2907	6	that	that	IN
cord-001835-0s7ok4uw	2907	7	both	both	CC
cord-001835-0s7ok4uw	2907	8	IN	in	IN
cord-001835-0s7ok4uw	2907	9	variants	variant	NNS
cord-001835-0s7ok4uw	2907	10	are	be	VBP
cord-001835-0s7ok4uw	2907	11	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	2907	12	by	by	IN
cord-001835-0s7ok4uw	2907	13	co	co	NN
cord-001835-0s7ok4uw	2907	14	-	-	NN
cord-001835-0s7ok4uw	2907	15	expression	expression	NN
cord-001835-0s7ok4uw	2907	16	with	with	IN
cord-001835-0s7ok4uw	2907	17	Ku70	Ku70	NNP
cord-001835-0s7ok4uw	2907	18	by	by	IN
cord-001835-0s7ok4uw	2907	19	approx	approx	NN
cord-001835-0s7ok4uw	2907	20	.	.	.
cord-001835-0s7ok4uw	2908	1	twofold	twofold	RB
cord-001835-0s7ok4uw	2908	2	.	.	.
cord-001835-0s7ok4uw	2909	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2909	2	hypothesize	hypothesize	VBP
cord-001835-0s7ok4uw	2909	3	that	that	IN
cord-001835-0s7ok4uw	2909	4	the	the	DT
cord-001835-0s7ok4uw	2909	5	binding	binding	NN
cord-001835-0s7ok4uw	2909	6	surface	surface	NN
cord-001835-0s7ok4uw	2909	7	within	within	IN
cord-001835-0s7ok4uw	2909	8	IN	in	IN
cord-001835-0s7ok4uw	2909	9	lies	lie	NNS
cord-001835-0s7ok4uw	2909	10	in	in	IN
cord-001835-0s7ok4uw	2909	11	the	the	DT
cord-001835-0s7ok4uw	2909	12	region	region	NN
cord-001835-0s7ok4uw	2909	13	from	from	IN
cord-001835-0s7ok4uw	2909	14	160	160	CD
cord-001835-0s7ok4uw	2909	15	to	to	IN
cord-001835-0s7ok4uw	2909	16	230	230	CD
cord-001835-0s7ok4uw	2909	17	a.a	a.a	NNP
cord-001835-0s7ok4uw	2909	18	.	.	NNP
cord-001835-0s7ok4uw	2909	19	that	that	DT
cord-001835-0s7ok4uw	2909	20	is	be	VBZ
cord-001835-0s7ok4uw	2909	21	a	a	DT
cord-001835-0s7ok4uw	2909	22	long	long	JJ
cord-001835-0s7ok4uw	2909	23	a	a	DT
cord-001835-0s7ok4uw	2909	24	-	-	HYPH
cord-001835-0s7ok4uw	2909	25	helix	helix	NN
cord-001835-0s7ok4uw	2909	26	.	.	.
cord-001835-0s7ok4uw	2910	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2910	2	have	have	VBP
cord-001835-0s7ok4uw	2910	3	shown	show	VBN
cord-001835-0s7ok4uw	2910	4	that	that	IN
cord-001835-0s7ok4uw	2910	5	a	a	DT
cord-001835-0s7ok4uw	2910	6	homologous	homologous	JJ
cord-001835-0s7ok4uw	2910	7	integrase	integrase	NN
cord-001835-0s7ok4uw	2910	8	from	from	IN
cord-001835-0s7ok4uw	2910	9	prototype	prototype	NN
cord-001835-0s7ok4uw	2910	10	foamy	foamy	NN
cord-001835-0s7ok4uw	2910	11	virus	virus	NN
cord-001835-0s7ok4uw	2910	12	that	that	WDT
cord-001835-0s7ok4uw	2910	13	lacks	lack	VBZ
cord-001835-0s7ok4uw	2910	14	this	this	DT
cord-001835-0s7ok4uw	2910	15	structural	structural	JJ
cord-001835-0s7ok4uw	2910	16	element	element	NN
cord-001835-0s7ok4uw	2910	17	does	do	VBZ
cord-001835-0s7ok4uw	2910	18	not	not	RB
cord-001835-0s7ok4uw	2910	19	bind	bind	VB
cord-001835-0s7ok4uw	2910	20	to	to	IN
cord-001835-0s7ok4uw	2910	21	Ku70	Ku70	NNP
cord-001835-0s7ok4uw	2910	22	.	.	.
cord-001835-0s7ok4uw	2911	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2911	2	is	be	VBZ
cord-001835-0s7ok4uw	2911	3	worth	worth	JJ
cord-001835-0s7ok4uw	2911	4	noting	note	VBG
cord-001835-0s7ok4uw	2911	5	that	that	IN
cord-001835-0s7ok4uw	2911	6	Ku70	Ku70	NNP
cord-001835-0s7ok4uw	2911	7	does	do	VBZ
cord-001835-0s7ok4uw	2911	8	not	not	RB
cord-001835-0s7ok4uw	2911	9	affect	affect	VB
cord-001835-0s7ok4uw	2911	10	the	the	DT
cord-001835-0s7ok4uw	2911	11	interaction	interaction	NN
cord-001835-0s7ok4uw	2911	12	of	of	IN
cord-001835-0s7ok4uw	2911	13	IN	in	RB
cord-001835-0s7ok4uw	2911	14	with	with	IN
cord-001835-0s7ok4uw	2911	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2911	16	major	major	JJ
cord-001835-0s7ok4uw	2911	17	cellular	cellular	JJ
cord-001835-0s7ok4uw	2911	18	partner	partner	NN
cord-001835-0s7ok4uw	2911	19	-LEDGF	-ledgf	NN
cord-001835-0s7ok4uw	2911	20	/	/	SYM
cord-001835-0s7ok4uw	2911	21	p75	p75	NNP
cord-001835-0s7ok4uw	2911	22	as	as	RB
cord-001835-0s7ok4uw	2911	23	well	well	RB
cord-001835-0s7ok4uw	2911	24	as	as	IN
cord-001835-0s7ok4uw	2911	25	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2911	26	interaction	interaction	NN
cord-001835-0s7ok4uw	2911	27	with	with	IN
cord-001835-0s7ok4uw	2911	28	the	the	DT
cord-001835-0s7ok4uw	2911	29	DNA	dna	NN
cord-001835-0s7ok4uw	2911	30	substrate	substrate	NN
cord-001835-0s7ok4uw	2911	31	.	.	.
cord-001835-0s7ok4uw	2912	1	This	this	DT
cord-001835-0s7ok4uw	2912	2	work	work	NN
cord-001835-0s7ok4uw	2912	3	was	be	VBD
cord-001835-0s7ok4uw	2912	4	supported	support	VBN
cord-001835-0s7ok4uw	2912	5	by	by	IN
cord-001835-0s7ok4uw	2912	6	an	an	DT
cord-001835-0s7ok4uw	2912	7	RFBR	RFBR	NNP
cord-001835-0s7ok4uw	2912	8	grant	grant	NN
cord-001835-0s7ok4uw	2912	9	14	14	CD
cord-001835-0s7ok4uw	2912	10	-	-	HYPH
cord-001835-0s7ok4uw	2912	11	04	04	CD
cord-001835-0s7ok4uw	2912	12	-	-	HYPH
cord-001835-0s7ok4uw	2912	13	00833	00833	CD
cord-001835-0s7ok4uw	2912	14	and	and	CC
cord-001835-0s7ok4uw	2912	15	by	by	IN
cord-001835-0s7ok4uw	2912	16	an	an	DT
cord-001835-0s7ok4uw	2912	17	RSCF	RSCF	NNP
cord-001835-0s7ok4uw	2912	18	grant	grant	NN
cord-001835-0s7ok4uw	2912	19	14	14	CD
cord-001835-0s7ok4uw	2912	20	-	-	HYPH
cord-001835-0s7ok4uw	2912	21	14	14	CD
cord-001835-0s7ok4uw	2912	22	-	-	HYPH
cord-001835-0s7ok4uw	2912	23	00489	00489	CD
cord-001835-0s7ok4uw	2912	24	.	.	.
cord-001835-0s7ok4uw	2912	25	 	 	_SP
cord-001835-0s7ok4uw	2913	1	The	the	DT
cord-001835-0s7ok4uw	2913	2	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2913	3	-	-	HYPH
cord-001835-0s7ok4uw	2913	4	dependent	dependent	JJ
cord-001835-0s7ok4uw	2913	5	Cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	2913	6	P450	P450	NNP
cord-001835-0s7ok4uw	2913	7	Oxidoreductase	Oxidoreductase	NNP
cord-001835-0s7ok4uw	2913	8	(	(	-LRB-
cord-001835-0s7ok4uw	2913	9	CYPOR	CYPOR	NNP
cord-001835-0s7ok4uw	2913	10	)	)	-RRB-
cord-001835-0s7ok4uw	2913	11	is	be	VBZ
cord-001835-0s7ok4uw	2913	12	large	large	JJ
cord-001835-0s7ok4uw	2913	13	677	677	CD
cord-001835-0s7ok4uw	2913	14	amino	amino	NN
cord-001835-0s7ok4uw	2913	15	-	-	HYPH
cord-001835-0s7ok4uw	2913	16	acid	acid	NN
cord-001835-0s7ok4uw	2913	17	long	long	JJ
cord-001835-0s7ok4uw	2913	18	microsomal	microsomal	NNP
cord-001835-0s7ok4uw	2913	19	multidomain	multidomain	NNP
cord-001835-0s7ok4uw	2913	20	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2913	21	responsible	responsible	JJ
cord-001835-0s7ok4uw	2913	22	for	for	IN
cord-001835-0s7ok4uw	2913	23	electron	electron	NN
cord-001835-0s7ok4uw	2913	24	donation	donation	NN
cord-001835-0s7ok4uw	2913	25	to	to	IN
cord-001835-0s7ok4uw	2913	26	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2913	27	redox	redox	JJ
cord-001835-0s7ok4uw	2913	28	partner	partner	NN
cord-001835-0s7ok4uw	2913	29	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	2913	30	P450	P450	NNPS
cord-001835-0s7ok4uw	2913	31	(	(	-LRB-
cord-001835-0s7ok4uw	2913	32	CYP	CYP	NNP
cord-001835-0s7ok4uw	2913	33	)	)	-RRB-
cord-001835-0s7ok4uw	2913	34	involved	involve	VBN
cord-001835-0s7ok4uw	2913	35	in	in	IN
cord-001835-0s7ok4uw	2913	36	drug	drug	NN
cord-001835-0s7ok4uw	2913	37	metabolism	metabolism	NN
cord-001835-0s7ok4uw	2913	38	.	.	.
cord-001835-0s7ok4uw	2914	1	Electron	electron	NN
cord-001835-0s7ok4uw	2914	2	transfer	transfer	NN
cord-001835-0s7ok4uw	2914	3	(	(	-LRB-
cord-001835-0s7ok4uw	2914	4	ET	et	NN
cord-001835-0s7ok4uw	2914	5	)	)	-RRB-
cord-001835-0s7ok4uw	2914	6	chain	chain	NN
cord-001835-0s7ok4uw	2914	7	is	be	VBZ
cord-001835-0s7ok4uw	2914	8	mediated	mediate	VBN
cord-001835-0s7ok4uw	2914	9	by	by	IN
cord-001835-0s7ok4uw	2914	10	two	two	CD
cord-001835-0s7ok4uw	2914	11	riboflavin	riboflavin	NN
cord-001835-0s7ok4uw	2914	12	-	-	HYPH
cord-001835-0s7ok4uw	2914	13	based	base	VBN
cord-001835-0s7ok4uw	2914	14	cofactors	cofactor	NNS
cord-001835-0s7ok4uw	2914	15	-flavin	-flavin	VBP
cord-001835-0s7ok4uw	2914	16	mononucleotide	mononucleotide	NNP
cord-001835-0s7ok4uw	2914	17	(	(	-LRB-
cord-001835-0s7ok4uw	2914	18	FMN	FMN	NNP
cord-001835-0s7ok4uw	2914	19	)	)	-RRB-
cord-001835-0s7ok4uw	2914	20	and	and	CC
cord-001835-0s7ok4uw	2914	21	flavin	flavin	NN
cord-001835-0s7ok4uw	2914	22	adenine	adenine	NN
cord-001835-0s7ok4uw	2914	23	dinucleotide	dinucleotide	NN
cord-001835-0s7ok4uw	2914	24	(	(	-LRB-
cord-001835-0s7ok4uw	2914	25	FAD	fad	NN
cord-001835-0s7ok4uw	2914	26	)	)	-RRB-
cord-001835-0s7ok4uw	2914	27	within	within	IN
cord-001835-0s7ok4uw	2914	28	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2914	29	respective	respective	JJ
cord-001835-0s7ok4uw	2914	30	domains	domain	NNS
cord-001835-0s7ok4uw	2914	31	and	and	CC
cord-001835-0s7ok4uw	2914	32	nicotinamide	nicotinamide	NN
cord-001835-0s7ok4uw	2914	33	adenine	adenine	NN
cord-001835-0s7ok4uw	2914	34	dinucleotide	dinucleotide	NN
cord-001835-0s7ok4uw	2914	35	phosphate	phosphate	NN
cord-001835-0s7ok4uw	2914	36	(	(	-LRB-
cord-001835-0s7ok4uw	2914	37	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2914	38	)	)	-RRB-
cord-001835-0s7ok4uw	2914	39	.	.	.
cord-001835-0s7ok4uw	2915	1	During	during	IN
cord-001835-0s7ok4uw	2915	2	this	this	DT
cord-001835-0s7ok4uw	2915	3	electron	electron	NN
cord-001835-0s7ok4uw	2915	4	transfer	transfer	NN
cord-001835-0s7ok4uw	2915	5	CYPOR	cypor	NN
cord-001835-0s7ok4uw	2915	6	undergoes	undergo	VBZ
cord-001835-0s7ok4uw	2915	7	several	several	JJ
cord-001835-0s7ok4uw	2915	8	structural	structural	JJ
cord-001835-0s7ok4uw	2915	9	changes	change	NNS
cord-001835-0s7ok4uw	2915	10	in	in	IN
cord-001835-0s7ok4uw	2915	11	open	open	JJ
cord-001835-0s7ok4uw	2915	12	and	and	CC
cord-001835-0s7ok4uw	2915	13	closed	closed	JJ
cord-001835-0s7ok4uw	2915	14	state	state	NN
cord-001835-0s7ok4uw	2915	15	of	of	IN
cord-001835-0s7ok4uw	2915	16	both	both	DT
cord-001835-0s7ok4uw	2915	17	domains	domain	NNS
cord-001835-0s7ok4uw	2915	18	in	in	IN
cord-001835-0s7ok4uw	2915	19	different	different	JJ
cord-001835-0s7ok4uw	2915	20	degree	degree	NN
cord-001835-0s7ok4uw	2915	21	of	of	IN
cord-001835-0s7ok4uw	2915	22	contact	contact	NN
cord-001835-0s7ok4uw	2915	23	.	.	.
cord-001835-0s7ok4uw	2916	1	In	in	IN
cord-001835-0s7ok4uw	2916	2	spite	spite	NN
cord-001835-0s7ok4uw	2916	3	of	of	IN
cord-001835-0s7ok4uw	2916	4	the	the	DT
cord-001835-0s7ok4uw	2916	5	fact	fact	NN
cord-001835-0s7ok4uw	2916	6	that	that	IN
cord-001835-0s7ok4uw	2916	7	CYP	CYP	NNP
cord-001835-0s7ok4uw	2916	8	-	-	HYPH
cord-001835-0s7ok4uw	2916	9	CYPOR	CYPOR	NNP
cord-001835-0s7ok4uw	2916	10	complexes	complex	NNS
cord-001835-0s7ok4uw	2916	11	play	play	VBP
cord-001835-0s7ok4uw	2916	12	a	a	DT
cord-001835-0s7ok4uw	2916	13	key	key	JJ
cord-001835-0s7ok4uw	2916	14	role	role	NN
cord-001835-0s7ok4uw	2916	15	in	in	IN
cord-001835-0s7ok4uw	2916	16	drug	drug	NN
cord-001835-0s7ok4uw	2916	17	metabolism	metabolism	NN
cord-001835-0s7ok4uw	2916	18	,	,	,
cord-001835-0s7ok4uw	2916	19	the	the	DT
cord-001835-0s7ok4uw	2916	20	atomistic	atomistic	JJ
cord-001835-0s7ok4uw	2916	21	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2916	22	of	of	IN
cord-001835-0s7ok4uw	2916	23	structural	structural	JJ
cord-001835-0s7ok4uw	2916	24	rearrangements	rearrangement	NNS
cord-001835-0s7ok4uw	2916	25	during	during	IN
cord-001835-0s7ok4uw	2916	26	complex	complex	JJ
cord-001835-0s7ok4uw	2916	27	electron	electron	NN
cord-001835-0s7ok4uw	2916	28	transfers	transfer	NNS
cord-001835-0s7ok4uw	2916	29	is	be	VBZ
cord-001835-0s7ok4uw	2916	30	still	still	RB
cord-001835-0s7ok4uw	2916	31	lacking	lack	VBG
cord-001835-0s7ok4uw	2916	32	.	.	.
cord-001835-0s7ok4uw	2917	1	Here	here	RB
cord-001835-0s7ok4uw	2917	2	,	,	,
cord-001835-0s7ok4uw	2917	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2917	4	present	present	VBP
cord-001835-0s7ok4uw	2917	5	the	the	DT
cord-001835-0s7ok4uw	2917	6	results	result	NNS
cord-001835-0s7ok4uw	2917	7	of	of	IN
cord-001835-0s7ok4uw	2917	8	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2917	9	study	study	NN
cord-001835-0s7ok4uw	2917	10	on	on	IN
cord-001835-0s7ok4uw	2917	11	structural	structural	JJ
cord-001835-0s7ok4uw	2917	12	changes	change	NNS
cord-001835-0s7ok4uw	2917	13	during	during	IN
cord-001835-0s7ok4uw	2917	14	CYPOR	CYPOR	NNP
cord-001835-0s7ok4uw	2917	15	multidomain	multidomain	NNP
cord-001835-0s7ok4uw	2917	16	complex	complex	JJ
cord-001835-0s7ok4uw	2917	17	movement	movement	NN
cord-001835-0s7ok4uw	2917	18	between	between	IN
cord-001835-0s7ok4uw	2917	19	individual	individual	JJ
cord-001835-0s7ok4uw	2917	20	electron	electron	NN
cord-001835-0s7ok4uw	2917	21	transfers	transfer	NNS
cord-001835-0s7ok4uw	2917	22	using	use	VBG
cord-001835-0s7ok4uw	2917	23	classical	classical	JJ
cord-001835-0s7ok4uw	2917	24	molecular	molecular	JJ
cord-001835-0s7ok4uw	2917	25	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2917	26	(	(	-LRB-
cord-001835-0s7ok4uw	2917	27	MD	MD	NNP
cord-001835-0s7ok4uw	2917	28	)	)	-RRB-
cord-001835-0s7ok4uw	2917	29	and	and	CC
cord-001835-0s7ok4uw	2917	30	metadynamics	metadynamic	NNS
cord-001835-0s7ok4uw	2917	31	(	(	-LRB-
cord-001835-0s7ok4uw	2917	32	MTD	MTD	NNP
cord-001835-0s7ok4uw	2917	33	)	)	-RRB-
cord-001835-0s7ok4uw	2917	34	simulations	simulation	NNS
cord-001835-0s7ok4uw	2917	35	with	with	IN
cord-001835-0s7ok4uw	2917	36	cofactors	cofactor	NNS
cord-001835-0s7ok4uw	2917	37	of	of	IN
cord-001835-0s7ok4uw	2917	38	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2917	39	,	,	,
cord-001835-0s7ok4uw	2917	40	FAD	FAD	NNP
cord-001835-0s7ok4uw	2917	41	and	and	CC
cord-001835-0s7ok4uw	2917	42	FMN	fmn	NN
cord-001835-0s7ok4uw	2917	43	in	in	IN
cord-001835-0s7ok4uw	2917	44	resting	rest	VBG
cord-001835-0s7ok4uw	2917	45	state	state	NN
cord-001835-0s7ok4uw	2917	46	.	.	.
cord-001835-0s7ok4uw	2918	1	Homology	homology	NN
cord-001835-0s7ok4uw	2918	2	model	model	NN
cord-001835-0s7ok4uw	2918	3	of	of	IN
cord-001835-0s7ok4uw	2918	4	human	human	JJ
cord-001835-0s7ok4uw	2918	5	CYPOR	cypor	NN
cord-001835-0s7ok4uw	2918	6	in	in	IN
cord-001835-0s7ok4uw	2918	7	both	both	DT
cord-001835-0s7ok4uw	2918	8	forms	form	NNS
cord-001835-0s7ok4uw	2918	9	(	(	-LRB-
cord-001835-0s7ok4uw	2918	10	opened	open	VBN
cord-001835-0s7ok4uw	2918	11	and	and	CC
cord-001835-0s7ok4uw	2918	12	closed	close	VBN
cord-001835-0s7ok4uw	2918	13	)	)	-RRB-
cord-001835-0s7ok4uw	2918	14	were	be	VBD
cord-001835-0s7ok4uw	2918	15	embedded	embed	VBN
cord-001835-0s7ok4uw	2918	16	into	into	IN
cord-001835-0s7ok4uw	2918	17	pure	pure	JJ
cord-001835-0s7ok4uw	2918	18	dioleoylphosphatidylcholine	dioleoylphosphatidylcholine	NN
cord-001835-0s7ok4uw	2918	19	(	(	-LRB-
cord-001835-0s7ok4uw	2918	20	DOPC	DOPC	NNP
cord-001835-0s7ok4uw	2918	21	)	)	-RRB-
cord-001835-0s7ok4uw	2918	22	bilayer	bilayer	NN
cord-001835-0s7ok4uw	2918	23	.	.	.
cord-001835-0s7ok4uw	2919	1	After	after	IN
cord-001835-0s7ok4uw	2919	2	system	system	NN
cord-001835-0s7ok4uw	2919	3	equilibration	equilibration	NN
cord-001835-0s7ok4uw	2919	4	(	(	-LRB-
cord-001835-0s7ok4uw	2919	5	Figure	figure	NN
cord-001835-0s7ok4uw	2919	6	1	1	CD
cord-001835-0s7ok4uw	2919	7	)	)	-RRB-
cord-001835-0s7ok4uw	2919	8	,	,	,
cord-001835-0s7ok4uw	2919	9	structural	structural	JJ
cord-001835-0s7ok4uw	2919	10	changes	change	NNS
cord-001835-0s7ok4uw	2919	11	of	of	IN
cord-001835-0s7ok4uw	2919	12	protein	protein	NN
cord-001835-0s7ok4uw	2919	13	,	,	,
cord-001835-0s7ok4uw	2919	14	anchor	anchor	NN
cord-001835-0s7ok4uw	2919	15	and	and	CC
cord-001835-0s7ok4uw	2919	16	cofactor	cofactor	NN
cord-001835-0s7ok4uw	2919	17	movement	movement	NN
cord-001835-0s7ok4uw	2919	18	were	be	VBD
cord-001835-0s7ok4uw	2919	19	studied	study	VBN
cord-001835-0s7ok4uw	2919	20	.	.	.
cord-001835-0s7ok4uw	2920	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2920	2	were	be	VBD
cord-001835-0s7ok4uw	2920	3	able	able	JJ
cord-001835-0s7ok4uw	2920	4	to	to	TO
cord-001835-0s7ok4uw	2920	5	select	select	VB
cord-001835-0s7ok4uw	2920	6	possible	possible	JJ
cord-001835-0s7ok4uw	2920	7	CYPOR	cypor	NN
cord-001835-0s7ok4uw	2920	8	-	-	HYPH
cord-001835-0s7ok4uw	2920	9	membrane	membrane	NN
cord-001835-0s7ok4uw	2920	10	orientation	orientation	NN
cord-001835-0s7ok4uw	2920	11	which	which	WDT
cord-001835-0s7ok4uw	2920	12	would	would	MD
cord-001835-0s7ok4uw	2920	13	allow	allow	VB
cord-001835-0s7ok4uw	2920	14	interaction	interaction	NN
cord-001835-0s7ok4uw	2920	15	with	with	IN
cord-001835-0s7ok4uw	2920	16	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	2920	17	P450	p450	NN
cord-001835-0s7ok4uw	2920	18	.	.	.
cord-001835-0s7ok4uw	2921	1	In	in	IN
cord-001835-0s7ok4uw	2921	2	addition	addition	NN
cord-001835-0s7ok4uw	2921	3	,	,	,
cord-001835-0s7ok4uw	2921	4	spontaneous	spontaneous	JJ
cord-001835-0s7ok4uw	2921	5	closing	closing	NN
cord-001835-0s7ok4uw	2921	6	of	of	IN
cord-001835-0s7ok4uw	2921	7	open	open	JJ
cord-001835-0s7ok4uw	2921	8	CYPOR	CYPOR	NNP
cord-001835-0s7ok4uw	2921	9	was	be	VBD
cord-001835-0s7ok4uw	2921	10	observed	observe	VBN
cord-001835-0s7ok4uw	2921	11	.	.	.
cord-001835-0s7ok4uw	2922	1	However	however	RB
cord-001835-0s7ok4uw	2922	2	structural	structural	JJ
cord-001835-0s7ok4uw	2922	3	changes	change	NNS
cord-001835-0s7ok4uw	2922	4	between	between	IN
cord-001835-0s7ok4uw	2922	5	crystal	crystal	NN
cord-001835-0s7ok4uw	2922	6	structures	structure	NNS
cord-001835-0s7ok4uw	2922	7	and	and	CC
cord-001835-0s7ok4uw	2922	8	structures	structure	NNS
cord-001835-0s7ok4uw	2922	9	obtain	obtain	VBP
cord-001835-0s7ok4uw	2922	10	from	from	IN
cord-001835-0s7ok4uw	2922	11	MD	MD	NNP
cord-001835-0s7ok4uw	2922	12	simulations	simulation	NNS
cord-001835-0s7ok4uw	2922	13	lead	lead	VBP
cord-001835-0s7ok4uw	2922	14	us	-PRON-	PRP
cord-001835-0s7ok4uw	2922	15	to	to	IN
cord-001835-0s7ok4uw	2922	16	the	the	DT
cord-001835-0s7ok4uw	2922	17	use	use	NN
cord-001835-0s7ok4uw	2922	18	of	of	IN
cord-001835-0s7ok4uw	2922	19	metadynamics	metadynamic	NNS
cord-001835-0s7ok4uw	2922	20	in	in	IN
cord-001835-0s7ok4uw	2922	21	order	order	NN
cord-001835-0s7ok4uw	2922	22	to	to	TO
cord-001835-0s7ok4uw	2922	23	speed	speed	VB
cord-001835-0s7ok4uw	2922	24	up	up	RP
cord-001835-0s7ok4uw	2922	25	the	the	DT
cord-001835-0s7ok4uw	2922	26	process	process	NN
cord-001835-0s7ok4uw	2922	27	.	.	.
cord-001835-0s7ok4uw	2923	1	FMN	fmn	NN
cord-001835-0s7ok4uw	2923	2	and	and	CC
cord-001835-0s7ok4uw	2923	3	FAD	fad	NN
cord-001835-0s7ok4uw	2923	4	cofactor	cofactor	NN
cord-001835-0s7ok4uw	2923	5	remained	remain	VBD
cord-001835-0s7ok4uw	2923	6	in	in	IN
cord-001835-0s7ok4uw	2923	7	close	close	JJ
cord-001835-0s7ok4uw	2923	8	van	van	NNP
cord-001835-0s7ok4uw	2923	9	der	der	NNP
cord-001835-0s7ok4uw	2923	10	Waals	Waals	NNP
cord-001835-0s7ok4uw	2923	11	contact	contact	NN
cord-001835-0s7ok4uw	2923	12	during	during	IN
cord-001835-0s7ok4uw	2923	13	the	the	DT
cord-001835-0s7ok4uw	2923	14	100-ns	100-ns	CD
cord-001835-0s7ok4uw	2923	15	long	long	JJ
cord-001835-0s7ok4uw	2923	16	simulation	simulation	NN
cord-001835-0s7ok4uw	2923	17	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	2923	18	by	by	IN
cord-001835-0s7ok4uw	2923	19	p	p	NN
cord-001835-0s7ok4uw	2923	20	stack	stack	NN
cord-001835-0s7ok4uw	2923	21	interaction	interaction	NN
cord-001835-0s7ok4uw	2923	22	of	of	IN
cord-001835-0s7ok4uw	2923	23	FAD	fad	NN
cord-001835-0s7ok4uw	2923	24	with	with	IN
cord-001835-0s7ok4uw	2923	25	Trp676	Trp676	,
cord-001835-0s7ok4uw	2923	26	,	,	,
cord-001835-0s7ok4uw	2923	27	whereas	whereas	IN
cord-001835-0s7ok4uw	2923	28	continual	continual	JJ
cord-001835-0s7ok4uw	2923	29	movement	movement	NN
cord-001835-0s7ok4uw	2923	30	of	of	IN
cord-001835-0s7ok4uw	2923	31	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2923	32	continually	continually	RB
cord-001835-0s7ok4uw	2923	33	weakens	weaken	VBZ
cord-001835-0s7ok4uw	2923	34	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2923	35	p	p	NN
cord-001835-0s7ok4uw	2923	36	stack	stack	NN
cord-001835-0s7ok4uw	2923	37	interaction	interaction	NN
cord-001835-0s7ok4uw	2923	38	with	with	IN
cord-001835-0s7ok4uw	2923	39	FAD	fad	NN
cord-001835-0s7ok4uw	2923	40	.	.	.
cord-001835-0s7ok4uw	2924	1	After	after	IN
cord-001835-0s7ok4uw	2924	2	100	100	CD
cord-001835-0s7ok4uw	2924	3	ns	n	NNS
cord-001835-0s7ok4uw	2924	4	of	of	IN
cord-001835-0s7ok4uw	2924	5	classical	classical	JJ
cord-001835-0s7ok4uw	2924	6	MD	MD	NNP
cord-001835-0s7ok4uw	2924	7	additional	additional	JJ
cord-001835-0s7ok4uw	2924	8	metadynamics	metadynamic	NNS
cord-001835-0s7ok4uw	2924	9	simulations	simulation	NNS
cord-001835-0s7ok4uw	2924	10	were	be	VBD
cord-001835-0s7ok4uw	2924	11	performed	perform	VBN
cord-001835-0s7ok4uw	2924	12	in	in	IN
cord-001835-0s7ok4uw	2924	13	order	order	NN
cord-001835-0s7ok4uw	2924	14	to	to	TO
cord-001835-0s7ok4uw	2924	15	investigate	investigate	VB
cord-001835-0s7ok4uw	2924	16	internal	internal	JJ
cord-001835-0s7ok4uw	2924	17	motion	motion	NN
cord-001835-0s7ok4uw	2924	18	of	of	IN
cord-001835-0s7ok4uw	2924	19	cofactors	cofactor	NNS
cord-001835-0s7ok4uw	2924	20	during	during	IN
cord-001835-0s7ok4uw	2924	21	electron	electron	NN
cord-001835-0s7ok4uw	2924	22	transfer	transfer	NN
cord-001835-0s7ok4uw	2924	23	.	.	.
cord-001835-0s7ok4uw	2925	1	Atoms	atom	NNS
cord-001835-0s7ok4uw	2925	2	C4N	C4N	NNS
cord-001835-0s7ok4uw	2925	3	(	(	-LRB-
cord-001835-0s7ok4uw	2925	4	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	2925	5	)	)	-RRB-
cord-001835-0s7ok4uw	2925	6	and	and	CC
cord-001835-0s7ok4uw	2925	7	N5	N5	NNP
cord-001835-0s7ok4uw	2925	8	(	(	-LRB-
cord-001835-0s7ok4uw	2925	9	FAD	fad	NN
cord-001835-0s7ok4uw	2925	10	)	)	-RRB-
cord-001835-0s7ok4uw	2925	11	which	which	WDT
cord-001835-0s7ok4uw	2925	12	are	be	VBP
cord-001835-0s7ok4uw	2925	13	responsible	responsible	JJ
cord-001835-0s7ok4uw	2925	14	for	for	IN
cord-001835-0s7ok4uw	2925	15	ET	ET	NNP
cord-001835-0s7ok4uw	2925	16	were	be	VBD
cord-001835-0s7ok4uw	2925	17	able	able	JJ
cord-001835-0s7ok4uw	2925	18	to	to	TO
cord-001835-0s7ok4uw	2925	19	move	move	VB
cord-001835-0s7ok4uw	2925	20	closer	close	RBR
cord-001835-0s7ok4uw	2925	21	to	to	IN
cord-001835-0s7ok4uw	2925	22	the	the	DT
cord-001835-0s7ok4uw	2925	23	distance	distance	NN
cord-001835-0s7ok4uw	2925	24	of	of	IN
cord-001835-0s7ok4uw	2925	25	3	3	CD
cord-001835-0s7ok4uw	2925	26	Å	å	NN
cord-001835-0s7ok4uw	2925	27	after	after	IN
cord-001835-0s7ok4uw	2925	28	adding	add	VBG
cord-001835-0s7ok4uw	2925	29	biasing	bias	VBG
cord-001835-0s7ok4uw	2925	30	potential	potential	NN
cord-001835-0s7ok4uw	2925	31	.	.	.
cord-001835-0s7ok4uw	2926	1	This	this	DT
cord-001835-0s7ok4uw	2926	2	distance	distance	NN
cord-001835-0s7ok4uw	2926	3	is	be	VBZ
cord-001835-0s7ok4uw	2926	4	more	more	JJR
cord-001835-0s7ok4uw	2926	5	than	than	IN
cord-001835-0s7ok4uw	2926	6	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	2926	7	for	for	IN
cord-001835-0s7ok4uw	2926	8	electron	electron	NN
cord-001835-0s7ok4uw	2926	9	transfer	transfer	NN
cord-001835-0s7ok4uw	2926	10	to	to	TO
cord-001835-0s7ok4uw	2926	11	occur	occur	VB
cord-001835-0s7ok4uw	2926	12	.	.	.
cord-001835-0s7ok4uw	2927	1	After	after	IN
cord-001835-0s7ok4uw	2927	2	switching	switch	VBG
cord-001835-0s7ok4uw	2927	3	back	back	RB
cord-001835-0s7ok4uw	2927	4	to	to	IN
cord-001835-0s7ok4uw	2927	5	classical	classical	JJ
cord-001835-0s7ok4uw	2927	6	MD	MD	NNP
cord-001835-0s7ok4uw	2927	7	cofactors	cofactor	NNS
cord-001835-0s7ok4uw	2927	8	got	get	VBD
cord-001835-0s7ok4uw	2927	9	into	into	IN
cord-001835-0s7ok4uw	2927	10	resting	rest	VBG
cord-001835-0s7ok4uw	2927	11	positions	position	NNS
cord-001835-0s7ok4uw	2927	12	(	(	-LRB-
cord-001835-0s7ok4uw	2927	13	8	8	CD
cord-001835-0s7ok4uw	2927	14	Å	å	NN
cord-001835-0s7ok4uw	2927	15	)	)	-RRB-
cord-001835-0s7ok4uw	2927	16	again	again	RB
cord-001835-0s7ok4uw	2927	17	.	.	.
cord-001835-0s7ok4uw	2928	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	2928	2	results	result	NNS
cord-001835-0s7ok4uw	2928	3	show	show	VBP
cord-001835-0s7ok4uw	2928	4	that	that	IN
cord-001835-0s7ok4uw	2928	5	CYPOR	CYPOR	NNP
cord-001835-0s7ok4uw	2928	6	undergo	undergo	VBP
cord-001835-0s7ok4uw	2928	7	several	several	JJ
cord-001835-0s7ok4uw	2928	8	structural	structural	JJ
cord-001835-0s7ok4uw	2928	9	changes	change	NNS
cord-001835-0s7ok4uw	2928	10	and	and	CC
cord-001835-0s7ok4uw	2928	11	internal	internal	JJ
cord-001835-0s7ok4uw	2928	12	motions	motion	NNS
cord-001835-0s7ok4uw	2928	13	of	of	IN
cord-001835-0s7ok4uw	2928	14	cofactors	cofactor	NNS
cord-001835-0s7ok4uw	2928	15	in	in	IN
cord-001835-0s7ok4uw	2928	16	order	order	NN
cord-001835-0s7ok4uw	2928	17	to	to	TO
cord-001835-0s7ok4uw	2928	18	transfer	transfer	VB
cord-001835-0s7ok4uw	2928	19	electrons	electron	NNS
cord-001835-0s7ok4uw	2928	20	to	to	IN
cord-001835-0s7ok4uw	2928	21	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2928	22	redox	redox	JJ
cord-001835-0s7ok4uw	2928	23	partner	partner	NN
cord-001835-0s7ok4uw	2928	24	-CYP	-cyp	RB
cord-001835-0s7ok4uw	2928	25	.	.	.
cord-001835-0s7ok4uw	2929	1	Research	Research	NNP
cord-001835-0s7ok4uw	2929	2	&	&	CC
cord-001835-0s7ok4uw	2929	3	Utilization	Utilization	NNP
cord-001835-0s7ok4uw	2929	4	Div	Div	NNP
cord-001835-0s7ok4uw	2929	5	.	.	NNP
cord-001835-0s7ok4uw	2929	6	,	,	,
cord-001835-0s7ok4uw	2929	7	JASRI	JASRI	NNP
cord-001835-0s7ok4uw	2929	8	/	/	SYM
cord-001835-0s7ok4uw	2929	9	SPring-8	SPring-8	NNP
cord-001835-0s7ok4uw	2929	10	,	,	,
cord-001835-0s7ok4uw	2929	11	2	2	CD
cord-001835-0s7ok4uw	2929	12	Grad	grad	NN
cord-001835-0s7ok4uw	2929	13	.	.	.
cord-001835-0s7ok4uw	2930	1	School	School	NNP
cord-001835-0s7ok4uw	2930	2	Frontier	Frontier	NNP
cord-001835-0s7ok4uw	2930	3	Sci	Sci	NNP
cord-001835-0s7ok4uw	2930	4	.	.	NNP
cord-001835-0s7ok4uw	2930	5	,	,	,
cord-001835-0s7ok4uw	2930	6	Univ	Univ	NNP
cord-001835-0s7ok4uw	2930	7	.	.	.
cord-001835-0s7ok4uw	2931	1	Tokyo	Tokyo	NNP
cord-001835-0s7ok4uw	2931	2	,	,	,
cord-001835-0s7ok4uw	2931	3	3	3	CD
cord-001835-0s7ok4uw	2931	4	Grad	grad	NN
cord-001835-0s7ok4uw	2931	5	.	.	.
cord-001835-0s7ok4uw	2932	1	Sch	Sch	NNP
cord-001835-0s7ok4uw	2932	2	.	.	.
cord-001835-0s7ok4uw	2933	1	Sci	Sci	NNP
cord-001835-0s7ok4uw	2933	2	.	.	NNP
cord-001835-0s7ok4uw	2933	3	,	,	,
cord-001835-0s7ok4uw	2933	4	Univ	Univ	NNP
cord-001835-0s7ok4uw	2933	5	.	.	.
cord-001835-0s7ok4uw	2934	1	Hyogo	Hyogo	NNP
cord-001835-0s7ok4uw	2934	2	,	,	,
cord-001835-0s7ok4uw	2934	3	Japan	Japan	NNP
cord-001835-0s7ok4uw	2934	4	,	,	,
cord-001835-0s7ok4uw	2934	5	4	4	CD
cord-001835-0s7ok4uw	2934	6	National	National	NNP
cord-001835-0s7ok4uw	2934	7	Institute	Institute	NNP
cord-001835-0s7ok4uw	2934	8	of	of	IN
cord-001835-0s7ok4uw	2934	9	Advanced	Advanced	NNP
cord-001835-0s7ok4uw	2934	10	Industrial	Industrial	NNP
cord-001835-0s7ok4uw	2934	11	Science	Science	NNP
cord-001835-0s7ok4uw	2934	12	and	and	CC
cord-001835-0s7ok4uw	2934	13	Technology	Technology	NNP
cord-001835-0s7ok4uw	2934	14	,	,	,
cord-001835-0s7ok4uw	2934	15	Japan	Japan	NNP
cord-001835-0s7ok4uw	2934	16	,	,	,
cord-001835-0s7ok4uw	2934	17	5	5	CD
cord-001835-0s7ok4uw	2934	18	 	 	_SP
cord-001835-0s7ok4uw	2934	19	Pentameric	Pentameric	NNP
cord-001835-0s7ok4uw	2934	20	ligand	ligand	NN
cord-001835-0s7ok4uw	2934	21	-	-	HYPH
cord-001835-0s7ok4uw	2934	22	gated	gate	VBN
cord-001835-0s7ok4uw	2934	23	ion	ion	NN
cord-001835-0s7ok4uw	2934	24	channels	channel	NNS
cord-001835-0s7ok4uw	2934	25	(	(	-LRB-
cord-001835-0s7ok4uw	2934	26	pLGICs	plgics	NN
cord-001835-0s7ok4uw	2934	27	)	)	-RRB-
cord-001835-0s7ok4uw	2934	28	are	be	VBP
cord-001835-0s7ok4uw	2934	29	a	a	DT
cord-001835-0s7ok4uw	2934	30	major	major	JJ
cord-001835-0s7ok4uw	2934	31	family	family	NN
cord-001835-0s7ok4uw	2934	32	of	of	IN
cord-001835-0s7ok4uw	2934	33	membrane	membrane	NN
cord-001835-0s7ok4uw	2934	34	receptors	receptor	NNS
cord-001835-0s7ok4uw	2934	35	that	that	WDT
cord-001835-0s7ok4uw	2934	36	open	open	VBP
cord-001835-0s7ok4uw	2934	37	to	to	TO
cord-001835-0s7ok4uw	2934	38	allow	allow	VB
cord-001835-0s7ok4uw	2934	39	ions	ion	NNS
cord-001835-0s7ok4uw	2934	40	to	to	TO
cord-001835-0s7ok4uw	2934	41	pass	pass	VB
cord-001835-0s7ok4uw	2934	42	through	through	IN
cord-001835-0s7ok4uw	2934	43	the	the	DT
cord-001835-0s7ok4uw	2934	44	membrane	membrane	NN
cord-001835-0s7ok4uw	2934	45	upon	upon	IN
cord-001835-0s7ok4uw	2934	46	binding	bind	VBG
cord-001835-0s7ok4uw	2934	47	of	of	IN
cord-001835-0s7ok4uw	2934	48	specific	specific	JJ
cord-001835-0s7ok4uw	2934	49	ligands	ligand	NNS
cord-001835-0s7ok4uw	2934	50	.	.	.
cord-001835-0s7ok4uw	2935	1	pLGICs	pLGICs	NNP
cord-001835-0s7ok4uw	2935	2	are	be	VBP
cord-001835-0s7ok4uw	2935	3	made	make	VBN
cord-001835-0s7ok4uw	2935	4	up	up	RP
cord-001835-0s7ok4uw	2935	5	of	of	IN
cord-001835-0s7ok4uw	2935	6	five	five	CD
cord-001835-0s7ok4uw	2935	7	identical	identical	JJ
cord-001835-0s7ok4uw	2935	8	(	(	-LRB-
cord-001835-0s7ok4uw	2935	9	homopentamers	homopentamer	NNS
cord-001835-0s7ok4uw	2935	10	)	)	-RRB-
cord-001835-0s7ok4uw	2935	11	or	or	CC
cord-001835-0s7ok4uw	2935	12	homologous	homologous	JJ
cord-001835-0s7ok4uw	2935	13	(	(	-LRB-
cord-001835-0s7ok4uw	2935	14	heteropentamers	heteropentamer	NNS
cord-001835-0s7ok4uw	2935	15	)	)	-RRB-
cord-001835-0s7ok4uw	2935	16	subunits	subunit	NNS
cord-001835-0s7ok4uw	2935	17	surrounding	surround	VBG
cord-001835-0s7ok4uw	2935	18	a	a	DT
cord-001835-0s7ok4uw	2935	19	central	central	JJ
cord-001835-0s7ok4uw	2935	20	pore	pore	NN
cord-001835-0s7ok4uw	2935	21	.	.	.
cord-001835-0s7ok4uw	2936	1	Structural	structural	JJ
cord-001835-0s7ok4uw	2936	2	information	information	NN
cord-001835-0s7ok4uw	2936	3	about	about	IN
cord-001835-0s7ok4uw	2936	4	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2936	5	multiple	multiple	JJ
cord-001835-0s7ok4uw	2936	6	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2936	7	states	state	NNS
cord-001835-0s7ok4uw	2936	8	,	,	,
cord-001835-0s7ok4uw	2936	9	carrying	carry	VBG
cord-001835-0s7ok4uw	2936	10	either	either	CC
cord-001835-0s7ok4uw	2936	11	an	an	DT
cord-001835-0s7ok4uw	2936	12	open	open	JJ
cord-001835-0s7ok4uw	2936	13	or	or	CC
cord-001835-0s7ok4uw	2936	14	a	a	DT
cord-001835-0s7ok4uw	2936	15	closed	closed	JJ
cord-001835-0s7ok4uw	2936	16	channel	channel	NN
cord-001835-0s7ok4uw	2936	17	,	,	,
cord-001835-0s7ok4uw	2936	18	has	have	VBZ
cord-001835-0s7ok4uw	2936	19	become	become	VBN
cord-001835-0s7ok4uw	2936	20	available	available	JJ
cord-001835-0s7ok4uw	2936	21	by	by	IN
cord-001835-0s7ok4uw	2936	22	recent	recent	JJ
cord-001835-0s7ok4uw	2936	23	studies	study	NNS
cord-001835-0s7ok4uw	2936	24	by	by	IN
cord-001835-0s7ok4uw	2936	25	X	x	NN
cord-001835-0s7ok4uw	2936	26	-	-	NN
cord-001835-0s7ok4uw	2936	27	ray	ray	NN
cord-001835-0s7ok4uw	2936	28	crystallography	crystallography	NN
cord-001835-0s7ok4uw	2936	29	.	.	.
cord-001835-0s7ok4uw	2937	1	However	however	RB
cord-001835-0s7ok4uw	2937	2	,	,	,
cord-001835-0s7ok4uw	2937	3	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2937	4	information	information	NN
cord-001835-0s7ok4uw	2937	5	are	be	VBP
cord-001835-0s7ok4uw	2937	6	needed	need	VBN
cord-001835-0s7ok4uw	2937	7	to	to	TO
cord-001835-0s7ok4uw	2937	8	understand	understand	VB
cord-001835-0s7ok4uw	2937	9	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2937	10	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2937	11	of	of	IN
cord-001835-0s7ok4uw	2937	12	gating	gating	NN
cord-001835-0s7ok4uw	2937	13	,	,	,
cord-001835-0s7ok4uw	2937	14	notably	notably	RB
cord-001835-0s7ok4uw	2937	15	the	the	DT
cord-001835-0s7ok4uw	2937	16	long	long	JJ
cord-001835-0s7ok4uw	2937	17	-	-	HYPH
cord-001835-0s7ok4uw	2937	18	range	range	NN
cord-001835-0s7ok4uw	2937	19	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2937	20	coupling	coupling	NN
cord-001835-0s7ok4uw	2937	21	between	between	IN
cord-001835-0s7ok4uw	2937	22	the	the	DT
cord-001835-0s7ok4uw	2937	23	agonist	agonist	NN
cord-001835-0s7ok4uw	2937	24	binding	bind	VBG
cord-001835-0s7ok4uw	2937	25	site	site	NN
cord-001835-0s7ok4uw	2937	26	and	and	CC
cord-001835-0s7ok4uw	2937	27	the	the	DT
cord-001835-0s7ok4uw	2937	28	ion	ion	NN
cord-001835-0s7ok4uw	2937	29	channel	channel	NN
cord-001835-0s7ok4uw	2937	30	gate	gate	NN
cord-001835-0s7ok4uw	2937	31	.	.	.
cord-001835-0s7ok4uw	2938	1	Here	here	RB
cord-001835-0s7ok4uw	2938	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	2938	3	used	use	VBD
cord-001835-0s7ok4uw	2938	4	the	the	DT
cord-001835-0s7ok4uw	2938	5	diffracted	diffract	VBN
cord-001835-0s7ok4uw	2938	6	X	x	NN
cord-001835-0s7ok4uw	2938	7	-	-	NN
cord-001835-0s7ok4uw	2938	8	ray	ray	NN
cord-001835-0s7ok4uw	2938	9	tracking	tracking	NN
cord-001835-0s7ok4uw	2938	10	(	(	-LRB-
cord-001835-0s7ok4uw	2938	11	DXT	DXT	NNP
cord-001835-0s7ok4uw	2938	12	)	)	-RRB-
cord-001835-0s7ok4uw	2938	13	method	method	NN
cord-001835-0s7ok4uw	2938	14	(	(	-LRB-
cord-001835-0s7ok4uw	2938	15	1	1	CD
cord-001835-0s7ok4uw	2938	16	)	)	-RRB-
cord-001835-0s7ok4uw	2938	17	to	to	TO
cord-001835-0s7ok4uw	2938	18	detect	detect	VB
cord-001835-0s7ok4uw	2938	19	the	the	DT
cord-001835-0s7ok4uw	2938	20	motion	motion	NN
cord-001835-0s7ok4uw	2938	21	of	of	IN
cord-001835-0s7ok4uw	2938	22	the	the	DT
cord-001835-0s7ok4uw	2938	23	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	2938	24	and	and	CC
cord-001835-0s7ok4uw	2938	25	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	2938	26	domain	domain	NN
cord-001835-0s7ok4uw	2938	27	two	two	CD
cord-001835-0s7ok4uw	2938	28	pLGICs	plgics	CD
cord-001835-0s7ok4uw	2938	29	:	:	:
cord-001835-0s7ok4uw	2938	30	the	the	DT
cord-001835-0s7ok4uw	2938	31	nicotinic	nicotinic	JJ
cord-001835-0s7ok4uw	2938	32	acetylcholine	acetylcholine	NN
cord-001835-0s7ok4uw	2938	33	receptor	receptor	NN
cord-001835-0s7ok4uw	2938	34	(	(	-LRB-
cord-001835-0s7ok4uw	2938	35	nAChR	nAChR	NNP
cord-001835-0s7ok4uw	2938	36	)	)	-RRB-
cord-001835-0s7ok4uw	2938	37	and	and	CC
cord-001835-0s7ok4uw	2938	38	a	a	DT
cord-001835-0s7ok4uw	2938	39	proton	proton	NN
cord-001835-0s7ok4uw	2938	40	-	-	HYPH
cord-001835-0s7ok4uw	2938	41	gated	gate	VBN
cord-001835-0s7ok4uw	2938	42	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	2938	43	ion	ion	NN
cord-001835-0s7ok4uw	2938	44	channel	channel	NN
cord-001835-0s7ok4uw	2938	45	from	from	IN
cord-001835-0s7ok4uw	2938	46	Gloeobacter	Gloeobacter	NNP
cord-001835-0s7ok4uw	2938	47	called	call	VBD
cord-001835-0s7ok4uw	2938	48	GLIC	GLIC	NNP
cord-001835-0s7ok4uw	2938	49	.	.	.
cord-001835-0s7ok4uw	2939	1	DXT	DXT	NNP
cord-001835-0s7ok4uw	2939	2	is	be	VBZ
cord-001835-0s7ok4uw	2939	3	a	a	DT
cord-001835-0s7ok4uw	2939	4	powerful	powerful	JJ
cord-001835-0s7ok4uw	2939	5	technique	technique	NN
cord-001835-0s7ok4uw	2939	6	in	in	IN
cord-001835-0s7ok4uw	2939	7	biological	biological	JJ
cord-001835-0s7ok4uw	2939	8	science	science	NN
cord-001835-0s7ok4uw	2939	9	for	for	IN
cord-001835-0s7ok4uw	2939	10	detecting	detect	VBG
cord-001835-0s7ok4uw	2939	11	atomic	atomic	JJ
cord-001835-0s7ok4uw	2939	12	-	-	HYPH
cord-001835-0s7ok4uw	2939	13	scale	scale	NN
cord-001835-0s7ok4uw	2939	14	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2939	15	motion	motion	NN
cord-001835-0s7ok4uw	2939	16	of	of	IN
cord-001835-0s7ok4uw	2939	17	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2939	18	proteins	protein	NNS
cord-001835-0s7ok4uw	2939	19	at	at	IN
cord-001835-0s7ok4uw	2939	20	the	the	DT
cord-001835-0s7ok4uw	2939	21	single	single	JJ
cord-001835-0s7ok4uw	2939	22	molecular	molecular	JJ
cord-001835-0s7ok4uw	2939	23	level	level	NN
cord-001835-0s7ok4uw	2939	24	and	and	CC
cord-001835-0s7ok4uw	2939	25	at	at	IN
cord-001835-0s7ok4uw	2939	26	tens	ten	NNS
cord-001835-0s7ok4uw	2939	27	of	of	IN
cord-001835-0s7ok4uw	2939	28	micro	micro	NNP
cord-001835-0s7ok4uw	2939	29	seconds	seconds	NNP
cord-001835-0s7ok4uw	2939	30	timescale	timescale	NN
cord-001835-0s7ok4uw	2939	31	resolution	resolution	NN
cord-001835-0s7ok4uw	2939	32	.	.	.
cord-001835-0s7ok4uw	2940	1	The	the	DT
cord-001835-0s7ok4uw	2940	2	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2940	3	of	of	IN
cord-001835-0s7ok4uw	2940	4	a	a	DT
cord-001835-0s7ok4uw	2940	5	single	single	JJ
cord-001835-0s7ok4uw	2940	6	protein	protein	NN
cord-001835-0s7ok4uw	2940	7	can	can	MD
cord-001835-0s7ok4uw	2940	8	be	be	VB
cord-001835-0s7ok4uw	2940	9	monitored	monitor	VBN
cord-001835-0s7ok4uw	2940	10	through	through	IN
cord-001835-0s7ok4uw	2940	11	trajectory	trajectory	NN
cord-001835-0s7ok4uw	2940	12	of	of	IN
cord-001835-0s7ok4uw	2940	13	a	a	DT
cord-001835-0s7ok4uw	2940	14	Laue	Laue	NNP
cord-001835-0s7ok4uw	2940	15	spot	spot	NN
cord-001835-0s7ok4uw	2940	16	from	from	IN
cord-001835-0s7ok4uw	2940	17	a	a	DT
cord-001835-0s7ok4uw	2940	18	nanocrystal	nanocrystal	NN
cord-001835-0s7ok4uw	2940	19	which	which	WDT
cord-001835-0s7ok4uw	2940	20	is	be	VBZ
cord-001835-0s7ok4uw	2940	21	attached	attach	VBN
cord-001835-0s7ok4uw	2940	22	to	to	IN
cord-001835-0s7ok4uw	2940	23	the	the	DT
cord-001835-0s7ok4uw	2940	24	target	target	NN
cord-001835-0s7ok4uw	2940	25	protein	protein	NN
cord-001835-0s7ok4uw	2940	26	immobilized	immobilize	VBN
cord-001835-0s7ok4uw	2940	27	on	on	IN
cord-001835-0s7ok4uw	2940	28	the	the	DT
cord-001835-0s7ok4uw	2940	29	substrate	substrate	NN
cord-001835-0s7ok4uw	2940	30	surface	surface	NN
cord-001835-0s7ok4uw	2940	31	(	(	-LRB-
cord-001835-0s7ok4uw	2940	32	2,3	2,3	CD
cord-001835-0s7ok4uw	2940	33	)	)	-RRB-
cord-001835-0s7ok4uw	2940	34	.	.	.
cord-001835-0s7ok4uw	2941	1	DXT	DXT	NNP
cord-001835-0s7ok4uw	2941	2	detects	detect	VBZ
cord-001835-0s7ok4uw	2941	3	two	two	CD
cord-001835-0s7ok4uw	2941	4	kinds	kind	NNS
cord-001835-0s7ok4uw	2941	5	of	of	IN
cord-001835-0s7ok4uw	2941	6	rotational	rotational	JJ
cord-001835-0s7ok4uw	2941	7	motions	motion	NNS
cord-001835-0s7ok4uw	2941	8	of	of	IN
cord-001835-0s7ok4uw	2941	9	nanocrystal	nanocrystal	NNP
cord-001835-0s7ok4uw	2941	10	,	,	,
cord-001835-0s7ok4uw	2941	11	tilting	tilt	VBG
cord-001835-0s7ok4uw	2941	12	and	and	CC
cord-001835-0s7ok4uw	2941	13	twisting	twist	VBG
cord-001835-0s7ok4uw	2941	14	,	,	,
cord-001835-0s7ok4uw	2941	15	based	base	VBN
cord-001835-0s7ok4uw	2941	16	on	on	IN
cord-001835-0s7ok4uw	2941	17	X	x	NN
cord-001835-0s7ok4uw	2941	18	-	-	NN
cord-001835-0s7ok4uw	2941	19	ray	ray	NN
cord-001835-0s7ok4uw	2941	20	incident	incident	NN
cord-001835-0s7ok4uw	2941	21	beam	beam	NN
cord-001835-0s7ok4uw	2941	22	axis	axis	NN
cord-001835-0s7ok4uw	2941	23	.	.	.
cord-001835-0s7ok4uw	2942	1	DXT	DXT	NNP
cord-001835-0s7ok4uw	2942	2	analysis	analysis	NN
cord-001835-0s7ok4uw	2942	3	with	with	IN
cord-001835-0s7ok4uw	2942	4	0.1ms/	0.1ms/	CD
cord-001835-0s7ok4uw	2943	1	f	f	NNP
cord-001835-0s7ok4uw	2943	2	time	time	NN
cord-001835-0s7ok4uw	2943	3	resolution	resolution	NN
cord-001835-0s7ok4uw	2943	4	showed	show	VBD
cord-001835-0s7ok4uw	2943	5	that	that	IN
cord-001835-0s7ok4uw	2943	6	tilting	tilt	VBG
cord-001835-0s7ok4uw	2943	7	motion	motion	NN
cord-001835-0s7ok4uw	2943	8	of	of	IN
cord-001835-0s7ok4uw	2943	9	the	the	DT
cord-001835-0s7ok4uw	2943	10	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	2943	11	domain	domain	NN
cord-001835-0s7ok4uw	2943	12	of	of	IN
cord-001835-0s7ok4uw	2943	13	GLIC	GLIC	NNP
cord-001835-0s7ok4uw	2943	14	and	and	CC
cord-001835-0s7ok4uw	2943	15	both	both	CC
cord-001835-0s7ok4uw	2943	16	tilting	tilt	VBG
cord-001835-0s7ok4uw	2943	17	and	and	CC
cord-001835-0s7ok4uw	2943	18	twisting	twist	VBG
cord-001835-0s7ok4uw	2943	19	motions	motion	NNS
cord-001835-0s7ok4uw	2943	20	of	of	IN
cord-001835-0s7ok4uw	2943	21	the	the	DT
cord-001835-0s7ok4uw	2943	22	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	2943	23	domain	domain	NN
cord-001835-0s7ok4uw	2943	24	of	of	IN
cord-001835-0s7ok4uw	2943	25	GLIC	GLIC	NNP
cord-001835-0s7ok4uw	2943	26	and	and	CC
cord-001835-0s7ok4uw	2943	27	nAChR	nAChR	NNP
cord-001835-0s7ok4uw	2943	28	were	be	VBD
cord-001835-0s7ok4uw	2943	29	enhanced	enhance	VBN
cord-001835-0s7ok4uw	2943	30	upon	upon	IN
cord-001835-0s7ok4uw	2943	31	application	application	NN
cord-001835-0s7ok4uw	2943	32	of	of	IN
cord-001835-0s7ok4uw	2943	33	agonists	agonist	NNS
cord-001835-0s7ok4uw	2943	34	(	(	-LRB-
cord-001835-0s7ok4uw	2943	35	lowering	lower	VBG
cord-001835-0s7ok4uw	2943	36	the	the	DT
cord-001835-0s7ok4uw	2943	37	pH	ph	NN
cord-001835-0s7ok4uw	2943	38	for	for	IN
cord-001835-0s7ok4uw	2943	39	GLIC	GLIC	NNP
cord-001835-0s7ok4uw	2943	40	,	,	,
cord-001835-0s7ok4uw	2943	41	and	and	CC
cord-001835-0s7ok4uw	2943	42	binding	binding	NN
cord-001835-0s7ok4uw	2943	43	of	of	IN
cord-001835-0s7ok4uw	2943	44	acetylcholine	acetylcholine	NN
cord-001835-0s7ok4uw	2943	45	for	for	IN
cord-001835-0s7ok4uw	2943	46	nAChR	nAChR	NNP
cord-001835-0s7ok4uw	2943	47	)	)	-RRB-
cord-001835-0s7ok4uw	2943	48	.	.	.
cord-001835-0s7ok4uw	2944	1	The	the	DT
cord-001835-0s7ok4uw	2944	2	detailed	detailed	JJ
cord-001835-0s7ok4uw	2944	3	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2944	4	information	information	NN
cord-001835-0s7ok4uw	2944	5	,	,	,
cord-001835-0s7ok4uw	2944	6	including	include	VBG
cord-001835-0s7ok4uw	2944	7	size	size	NN
cord-001835-0s7ok4uw	2944	8	effect	effect	NN
cord-001835-0s7ok4uw	2944	9	of	of	IN
cord-001835-0s7ok4uw	2944	10	gold	gold	NN
cord-001835-0s7ok4uw	2944	11	nanocrystal	nanocrystal	NN
cord-001835-0s7ok4uw	2944	12	to	to	IN
cord-001835-0s7ok4uw	2944	13	the	the	DT
cord-001835-0s7ok4uw	2944	14	motion	motion	NN
cord-001835-0s7ok4uw	2944	15	of	of	IN
cord-001835-0s7ok4uw	2944	16	them	-PRON-	PRP
cord-001835-0s7ok4uw	2944	17	,	,	,
cord-001835-0s7ok4uw	2944	18	is	be	VBZ
cord-001835-0s7ok4uw	2944	19	discussed	discuss	VBN
cord-001835-0s7ok4uw	2944	20	.	.	.
cord-001835-0s7ok4uw	2945	1	[	[	-LRB-
cord-001835-0s7ok4uw	2945	2	Proteins	protein	NNS
cord-001835-0s7ok4uw	2945	3	possess	possess	VBP
cord-001835-0s7ok4uw	2945	4	unique	unique	JJ
cord-001835-0s7ok4uw	2945	5	structure	structure	NN
cord-001835-0s7ok4uw	2945	6	-	-	HYPH
cord-001835-0s7ok4uw	2945	7	encoded	encode	VBN
cord-001835-0s7ok4uw	2945	8	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2945	9	that	that	WDT
cord-001835-0s7ok4uw	2945	10	underlie	underlie	VBP
cord-001835-0s7ok4uw	2945	11	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2945	12	biological	biological	JJ
cord-001835-0s7ok4uw	2945	13	functions	function	NNS
cord-001835-0s7ok4uw	2945	14	.	.	.
cord-001835-0s7ok4uw	2946	1	Here	here	RB
cord-001835-0s7ok4uw	2946	2	,	,	,
cord-001835-0s7ok4uw	2946	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2946	4	provide	provide	VBP
cord-001835-0s7ok4uw	2946	5	experimental	experimental	JJ
cord-001835-0s7ok4uw	2946	6	evidence	evidence	NN
cord-001835-0s7ok4uw	2946	7	for	for	IN
cord-001835-0s7ok4uw	2946	8	an	an	DT
cord-001835-0s7ok4uw	2946	9	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	2946	10	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2946	11	driven	drive	VBN
cord-001835-0s7ok4uw	2946	12	solely	solely	RB
cord-001835-0s7ok4uw	2946	13	by	by	IN
cord-001835-0s7ok4uw	2946	14	long	long	JJ
cord-001835-0s7ok4uw	2946	15	-	-	HYPH
cord-001835-0s7ok4uw	2946	16	range	range	NN
cord-001835-0s7ok4uw	2946	17	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2946	18	motions	motion	NNS
cord-001835-0s7ok4uw	2946	19	without	without	IN
cord-001835-0s7ok4uw	2946	20	significant	significant	JJ
cord-001835-0s7ok4uw	2946	21	backbone	backbone	NN
cord-001835-0s7ok4uw	2946	22	adjustments	adjustment	NNS
cord-001835-0s7ok4uw	2946	23	,	,	,
cord-001835-0s7ok4uw	2946	24	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	2946	25	group	group	NN
cord-001835-0s7ok4uw	2946	26	rearrangements	rearrangement	NNS
cord-001835-0s7ok4uw	2946	27	,	,	,
cord-001835-0s7ok4uw	2946	28	or	or	CC
cord-001835-0s7ok4uw	2946	29	changes	change	NNS
cord-001835-0s7ok4uw	2946	30	in	in	IN
cord-001835-0s7ok4uw	2946	31	subunit	subunit	NN
cord-001835-0s7ok4uw	2946	32	assembly	assembly	NN
cord-001835-0s7ok4uw	2946	33	.	.	.
cord-001835-0s7ok4uw	2947	1	Crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	2947	2	structures	structure	NNS
cord-001835-0s7ok4uw	2947	3	were	be	VBD
cord-001835-0s7ok4uw	2947	4	determined	determine	VBN
cord-001835-0s7ok4uw	2947	5	for	for	IN
cord-001835-0s7ok4uw	2947	6	several	several	JJ
cord-001835-0s7ok4uw	2947	7	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	2947	8	GFP	GFP	NNP
cord-001835-0s7ok4uw	2947	9	-	-	HYPH
cord-001835-0s7ok4uw	2947	10	like	like	JJ
cord-001835-0s7ok4uw	2947	11	proteins	protein	NNS
cord-001835-0s7ok4uw	2947	12	that	that	WDT
cord-001835-0s7ok4uw	2947	13	were	be	VBD
cord-001835-0s7ok4uw	2947	14	reconstructed	reconstruct	VBN
cord-001835-0s7ok4uw	2947	15	based	base	VBN
cord-001835-0s7ok4uw	2947	16	on	on	IN
cord-001835-0s7ok4uw	2947	17	posterior	posterior	JJ
cord-001835-0s7ok4uw	2947	18	sequence	sequence	NN
cord-001835-0s7ok4uw	2947	19	predictions	prediction	NNS
cord-001835-0s7ok4uw	2947	20	,	,	,
cord-001835-0s7ok4uw	2947	21	using	use	VBG
cord-001835-0s7ok4uw	2947	22	members	member	NNS
cord-001835-0s7ok4uw	2947	23	of	of	IN
cord-001835-0s7ok4uw	2947	24	the	the	DT
cord-001835-0s7ok4uw	2947	25	stony	stony	JJ
cord-001835-0s7ok4uw	2947	26	coral	coral	NN
cord-001835-0s7ok4uw	2947	27	suborder	suborder	NN
cord-001835-0s7ok4uw	2947	28	Faviina	Faviina	NNP
cord-001835-0s7ok4uw	2947	29	as	as	IN
cord-001835-0s7ok4uw	2947	30	a	a	DT
cord-001835-0s7ok4uw	2947	31	model	model	NN
cord-001835-0s7ok4uw	2947	32	system	system	NN
cord-001835-0s7ok4uw	2947	33	.	.	.
cord-001835-0s7ok4uw	2948	1	The	the	DT
cord-001835-0s7ok4uw	2948	2	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	2948	3	proteins	protein	NNS
cord-001835-0s7ok4uw	2948	4	belong	belong	VBP
cord-001835-0s7ok4uw	2948	5	to	to	IN
cord-001835-0s7ok4uw	2948	6	the	the	DT
cord-001835-0s7ok4uw	2948	7	Kaede	Kaede	NNP
cord-001835-0s7ok4uw	2948	8	-	-	HYPH
cord-001835-0s7ok4uw	2948	9	type	type	NN
cord-001835-0s7ok4uw	2948	10	class	class	NN
cord-001835-0s7ok4uw	2948	11	of	of	IN
cord-001835-0s7ok4uw	2948	12	GFPs	gfp	NNS
cord-001835-0s7ok4uw	2948	13	,	,	,
cord-001835-0s7ok4uw	2948	14	a	a	DT
cord-001835-0s7ok4uw	2948	15	group	group	NN
cord-001835-0s7ok4uw	2948	16	of	of	IN
cord-001835-0s7ok4uw	2948	17	proteins	protein	NNS
cord-001835-0s7ok4uw	2948	18	that	that	WDT
cord-001835-0s7ok4uw	2948	19	undergoes	undergo	VBZ
cord-001835-0s7ok4uw	2948	20	irreversible	irreversible	JJ
cord-001835-0s7ok4uw	2948	21	green	green	NN
cord-001835-0s7ok4uw	2948	22	-	-	HYPH
cord-001835-0s7ok4uw	2948	23	to	to	IN
cord-001835-0s7ok4uw	2948	24	-	-	HYPH
cord-001835-0s7ok4uw	2948	25	red	red	JJ
cord-001835-0s7ok4uw	2948	26	photoconversion	photoconversion	NN
cord-001835-0s7ok4uw	2948	27	and	and	CC
cord-001835-0s7ok4uw	2948	28	is	be	VBZ
cord-001835-0s7ok4uw	2948	29	therefore	therefore	RB
cord-001835-0s7ok4uw	2948	30	frequently	frequently	RB
cord-001835-0s7ok4uw	2948	31	employed	employ	VBN
cord-001835-0s7ok4uw	2948	32	in	in	IN
cord-001835-0s7ok4uw	2948	33	superresolution	superresolution	NN
cord-001835-0s7ok4uw	2948	34	microscopy	microscopy	NNP
cord-001835-0s7ok4uw	2948	35	.	.	.
cord-001835-0s7ok4uw	2949	1	Surprisingly	surprisingly	RB
cord-001835-0s7ok4uw	2949	2	,	,	,
cord-001835-0s7ok4uw	2949	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2949	4	find	find	VBP
cord-001835-0s7ok4uw	2949	5	that	that	IN
cord-001835-0s7ok4uw	2949	6	the	the	DT
cord-001835-0s7ok4uw	2949	7	structures	structure	NNS
cord-001835-0s7ok4uw	2949	8	of	of	IN
cord-001835-0s7ok4uw	2949	9	reconstructed	reconstruct	VBN
cord-001835-0s7ok4uw	2949	10	common	common	JJ
cord-001835-0s7ok4uw	2949	11	green	green	JJ
cord-001835-0s7ok4uw	2949	12	ancestors	ancestor	NNS
cord-001835-0s7ok4uw	2949	13	and	and	CC
cord-001835-0s7ok4uw	2949	14	evolved	evolve	VBD
cord-001835-0s7ok4uw	2950	1	green	green	JJ
cord-001835-0s7ok4uw	2950	2	-	-	HYPH
cord-001835-0s7ok4uw	2950	3	to	to	IN
cord-001835-0s7ok4uw	2950	4	-	-	HYPH
cord-001835-0s7ok4uw	2950	5	red	red	JJ
cord-001835-0s7ok4uw	2950	6	photoconvertible	photoconvertible	NN
cord-001835-0s7ok4uw	2950	7	proteins	protein	NNS
cord-001835-0s7ok4uw	2950	8	are	be	VBP
cord-001835-0s7ok4uw	2950	9	very	very	RB
cord-001835-0s7ok4uw	2950	10	similar	similar	JJ
cord-001835-0s7ok4uw	2950	11	.	.	.
cord-001835-0s7ok4uw	2951	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	2951	2	,	,	,
cord-001835-0s7ok4uw	2951	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2951	4	analyzed	analyze	VBD
cord-001835-0s7ok4uw	2951	5	their	-PRON-	PRP$
cord-001835-0s7ok4uw	2951	6	chain	chain	NN
cord-001835-0s7ok4uw	2951	7	flexibility	flexibility	NN
cord-001835-0s7ok4uw	2951	8	using	use	VBG
cord-001835-0s7ok4uw	2951	9	molecular	molecular	JJ
cord-001835-0s7ok4uw	2951	10	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2951	11	and	and	CC
cord-001835-0s7ok4uw	2951	12	perturbation	perturbation	NN
cord-001835-0s7ok4uw	2951	13	response	response	NN
cord-001835-0s7ok4uw	2951	14	scanning	scanning	NN
cord-001835-0s7ok4uw	2951	15	.	.	.
cord-001835-0s7ok4uw	2952	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2952	2	find	find	VBP
cord-001835-0s7ok4uw	2952	3	that	that	IN
cord-001835-0s7ok4uw	2952	4	the	the	DT
cord-001835-0s7ok4uw	2952	5	minimal	minimal	JJ
cord-001835-0s7ok4uw	2952	6	number	number	NN
cord-001835-0s7ok4uw	2952	7	of	of	IN
cord-001835-0s7ok4uw	2952	8	residue	residue	NN
cord-001835-0s7ok4uw	2952	9	replacements	replacement	NNS
cord-001835-0s7ok4uw	2952	10	both	both	CC
cord-001835-0s7ok4uw	2952	11	necessary	necessary	JJ
cord-001835-0s7ok4uw	2952	12	and	and	CC
cord-001835-0s7ok4uw	2952	13	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	2952	14	to	to	TO
cord-001835-0s7ok4uw	2952	15	support	support	VB
cord-001835-0s7ok4uw	2952	16	lightinduced	lightinduced	JJ
cord-001835-0s7ok4uw	2952	17	color	color	NN
cord-001835-0s7ok4uw	2952	18	conversion	conversion	NN
cord-001835-0s7ok4uw	2952	19	provide	provide	VB
cord-001835-0s7ok4uw	2952	20	for	for	IN
cord-001835-0s7ok4uw	2952	21	increased	increase	VBN
cord-001835-0s7ok4uw	2952	22	fold	fold	JJ
cord-001835-0s7ok4uw	2952	23	stiffness	stiffness	NN
cord-001835-0s7ok4uw	2952	24	at	at	IN
cord-001835-0s7ok4uw	2952	25	a	a	DT
cord-001835-0s7ok4uw	2952	26	region	region	NN
cord-001835-0s7ok4uw	2952	27	remote	remote	JJ
cord-001835-0s7ok4uw	2952	28	from	from	IN
cord-001835-0s7ok4uw	2952	29	the	the	DT
cord-001835-0s7ok4uw	2952	30	active	active	JJ
cord-001835-0s7ok4uw	2952	31	site	site	NN
cord-001835-0s7ok4uw	2952	32	.	.	.
cord-001835-0s7ok4uw	2953	1	At	at	IN
cord-001835-0s7ok4uw	2953	2	the	the	DT
cord-001835-0s7ok4uw	2953	3	same	same	JJ
cord-001835-0s7ok4uw	2953	4	time	time	NN
cord-001835-0s7ok4uw	2953	5	,	,	,
cord-001835-0s7ok4uw	2953	6	the	the	DT
cord-001835-0s7ok4uw	2953	7	allosterically	allosterically	RB
cord-001835-0s7ok4uw	2953	8	coupled	couple	VBN
cord-001835-0s7ok4uw	2953	9	mutational	mutational	JJ
cord-001835-0s7ok4uw	2953	10	sites	site	NNS
cord-001835-0s7ok4uw	2953	11	appear	appear	VBP
cord-001835-0s7ok4uw	2953	12	to	to	TO
cord-001835-0s7ok4uw	2953	13	increase	increase	VB
cord-001835-0s7ok4uw	2953	14	active	active	JJ
cord-001835-0s7ok4uw	2953	15	site	site	NN
cord-001835-0s7ok4uw	2953	16	conformational	conformational	JJ
cord-001835-0s7ok4uw	2953	17	mobility	mobility	NN
cord-001835-0s7ok4uw	2953	18	via	via	IN
cord-001835-0s7ok4uw	2953	19	epistasis	epistasis	NN
cord-001835-0s7ok4uw	2953	20	.	.	.
cord-001835-0s7ok4uw	2954	1	These	these	DT
cord-001835-0s7ok4uw	2954	2	data	datum	NNS
cord-001835-0s7ok4uw	2954	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	2954	4	that	that	IN
cord-001835-0s7ok4uw	2954	5	during	during	IN
cord-001835-0s7ok4uw	2954	6	evolution	evolution	NN
cord-001835-0s7ok4uw	2954	7	,	,	,
cord-001835-0s7ok4uw	2954	8	the	the	DT
cord-001835-0s7ok4uw	2954	9	locations	location	NNS
cord-001835-0s7ok4uw	2954	10	of	of	IN
cord-001835-0s7ok4uw	2954	11	fold	fold	RB
cord-001835-0s7ok4uw	2954	12	-	-	HYPH
cord-001835-0s7ok4uw	2954	13	anchoring	anchor	VBG
cord-001835-0s7ok4uw	2954	14	and	and	CC
cord-001835-0s7ok4uw	2954	15	breathing	breathing	NN
cord-001835-0s7ok4uw	2954	16	regions	region	NNS
cord-001835-0s7ok4uw	2954	17	have	have	VBP
cord-001835-0s7ok4uw	2954	18	been	be	VBN
cord-001835-0s7ok4uw	2954	19	reversed	reverse	VBN
cord-001835-0s7ok4uw	2954	20	by	by	IN
cord-001835-0s7ok4uw	2954	21	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2954	22	means	mean	NNS
cord-001835-0s7ok4uw	2954	23	.	.	.
cord-001835-0s7ok4uw	2955	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	2955	2	,	,	,
cord-001835-0s7ok4uw	2955	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	2955	4	conclude	conclude	VBP
cord-001835-0s7ok4uw	2955	5	that	that	IN
cord-001835-0s7ok4uw	2955	6	the	the	DT
cord-001835-0s7ok4uw	2955	7	green	green	RB
cord-001835-0s7ok4uw	2955	8	-	-	HYPH
cord-001835-0s7ok4uw	2955	9	tored	tore	VBN
cord-001835-0s7ok4uw	2955	10	photoconvertible	photoconvertible	NN
cord-001835-0s7ok4uw	2955	11	phenotype	phenotype	NN
cord-001835-0s7ok4uw	2955	12	has	have	VBZ
cord-001835-0s7ok4uw	2955	13	arisen	arise	VBN
cord-001835-0s7ok4uw	2955	14	from	from	IN
cord-001835-0s7ok4uw	2955	15	a	a	DT
cord-001835-0s7ok4uw	2955	16	common	common	JJ
cord-001835-0s7ok4uw	2955	17	green	green	JJ
cord-001835-0s7ok4uw	2955	18	ancestor	ancestor	NN
cord-001835-0s7ok4uw	2955	19	by	by	IN
cord-001835-0s7ok4uw	2955	20	migration	migration	NN
cord-001835-0s7ok4uw	2955	21	of	of	IN
cord-001835-0s7ok4uw	2955	22	a	a	DT
cord-001835-0s7ok4uw	2955	23	knob	knob	NN
cord-001835-0s7ok4uw	2955	24	-	-	HYPH
cord-001835-0s7ok4uw	2955	25	like	like	JJ
cord-001835-0s7ok4uw	2955	26	anchoring	anchor	VBG
cord-001835-0s7ok4uw	2955	27	region	region	NN
cord-001835-0s7ok4uw	2955	28	away	away	RB
cord-001835-0s7ok4uw	2955	29	from	from	IN
cord-001835-0s7ok4uw	2955	30	the	the	DT
cord-001835-0s7ok4uw	2955	31	active	active	JJ
cord-001835-0s7ok4uw	2955	32	site	site	NN
cord-001835-0s7ok4uw	2955	33	diagonally	diagonally	RB
cord-001835-0s7ok4uw	2955	34	across	across	IN
cord-001835-0s7ok4uw	2955	35	the	the	DT
cord-001835-0s7ok4uw	2955	36	beta	beta	NN
cord-001835-0s7ok4uw	2955	37	-	-	HYPH
cord-001835-0s7ok4uw	2955	38	barrel	barrel	NN
cord-001835-0s7ok4uw	2955	39	fold	fold	NN
cord-001835-0s7ok4uw	2955	40	.	.	.
cord-001835-0s7ok4uw	2956	1	Based	base	VBN
cord-001835-0s7ok4uw	2956	2	on	on	IN
cord-001835-0s7ok4uw	2956	3	titration	titration	NN
cord-001835-0s7ok4uw	2956	4	experiments	experiment	NNS
cord-001835-0s7ok4uw	2956	5	,	,	,
cord-001835-0s7ok4uw	2956	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	2956	7	estimate	estimate	VBP
cord-001835-0s7ok4uw	2956	8	that	that	IN
cord-001835-0s7ok4uw	2956	9	at	at	IN
cord-001835-0s7ok4uw	2956	10	pH	pH	NNP
cord-001835-0s7ok4uw	2956	11	6	6	CD
cord-001835-0s7ok4uw	2956	12	,	,	,
cord-001835-0s7ok4uw	2956	13	0.1	0.1	CD
cord-001835-0s7ok4uw	2956	14	%	%	NN
cord-001835-0s7ok4uw	2956	15	of	of	IN
cord-001835-0s7ok4uw	2956	16	the	the	DT
cord-001835-0s7ok4uw	2956	17	protein	protein	NN
cord-001835-0s7ok4uw	2956	18	population	population	NN
cord-001835-0s7ok4uw	2956	19	harbors	harbor	VBZ
cord-001835-0s7ok4uw	2956	20	neutral	neutral	JJ
cord-001835-0s7ok4uw	2956	21	side	side	NN
cord-001835-0s7ok4uw	2956	22	chains	chain	NNS
cord-001835-0s7ok4uw	2956	23	for	for	IN
cord-001835-0s7ok4uw	2956	24	His193	his193	CD
cord-001835-0s7ok4uw	2957	1	and	and	CC
cord-001835-0s7ok4uw	2957	2	Glu211	Glu211	NNS
cord-001835-0s7ok4uw	2957	3	,	,	,
cord-001835-0s7ok4uw	2957	4	residues	residue	NNS
cord-001835-0s7ok4uw	2957	5	that	that	WDT
cord-001835-0s7ok4uw	2957	6	form	form	VBP
cord-001835-0s7ok4uw	2957	7	an	an	DT
cord-001835-0s7ok4uw	2957	8	internal	internal	JJ
cord-001835-0s7ok4uw	2957	9	salt	salt	NN
cord-001835-0s7ok4uw	2957	10	bridge	bridge	NN
cord-001835-0s7ok4uw	2957	11	near	near	IN
cord-001835-0s7ok4uw	2957	12	the	the	DT
cord-001835-0s7ok4uw	2957	13	chromophore	chromophore	NN
cord-001835-0s7ok4uw	2957	14	.	.	.
cord-001835-0s7ok4uw	2958	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2958	2	propose	propose	VBP
cord-001835-0s7ok4uw	2958	3	that	that	IN
cord-001835-0s7ok4uw	2958	4	this	this	DT
cord-001835-0s7ok4uw	2958	5	reverse	reverse	NN
cord-001835-0s7ok4uw	2958	6	-	-	HYPH
cord-001835-0s7ok4uw	2958	7	protonated	protonated	JJ
cord-001835-0s7ok4uw	2958	8	subpopulation	subpopulation	NN
cord-001835-0s7ok4uw	2958	9	constitutes	constitute	VBZ
cord-001835-0s7ok4uw	2958	10	the	the	DT
cord-001835-0s7ok4uw	2958	11	catalytically	catalytically	RB
cord-001835-0s7ok4uw	2958	12	competent	competent	JJ
cord-001835-0s7ok4uw	2958	13	state	state	NN
cord-001835-0s7ok4uw	2958	14	.	.	.
cord-001835-0s7ok4uw	2959	1	In	in	IN
cord-001835-0s7ok4uw	2959	2	the	the	DT
cord-001835-0s7ok4uw	2959	3	electronically	electronically	RB
cord-001835-0s7ok4uw	2959	4	excited	excite	VBN
cord-001835-0s7ok4uw	2959	5	state	state	NN
cord-001835-0s7ok4uw	2959	6	,	,	,
cord-001835-0s7ok4uw	2959	7	light	light	NN
cord-001835-0s7ok4uw	2959	8	-	-	HYPH
cord-001835-0s7ok4uw	2959	9	induced	induce	VBN
cord-001835-0s7ok4uw	2959	10	chromophore	chromophore	NN
cord-001835-0s7ok4uw	2959	11	twisting	twisting	NN
cord-001835-0s7ok4uw	2959	12	may	may	MD
cord-001835-0s7ok4uw	2959	13	be	be	VB
cord-001835-0s7ok4uw	2959	14	enhanced	enhance	VBN
cord-001835-0s7ok4uw	2959	15	,	,	,
cord-001835-0s7ok4uw	2959	16	activating	activate	VBG
cord-001835-0s7ok4uw	2959	17	internal	internal	JJ
cord-001835-0s7ok4uw	2959	18	acid	acid	NN
cord-001835-0s7ok4uw	2959	19	-	-	HYPH
cord-001835-0s7ok4uw	2959	20	base	base	NN
cord-001835-0s7ok4uw	2959	21	chemistry	chemistry	NN
cord-001835-0s7ok4uw	2959	22	that	that	WDT
cord-001835-0s7ok4uw	2959	23	facilitates	facilitate	VBZ
cord-001835-0s7ok4uw	2959	24	backbone	backbone	NN
cord-001835-0s7ok4uw	2959	25	cleavage	cleavage	NN
cord-001835-0s7ok4uw	2959	26	to	to	TO
cord-001835-0s7ok4uw	2959	27	enlarge	enlarge	VB
cord-001835-0s7ok4uw	2959	28	the	the	DT
cord-001835-0s7ok4uw	2959	29	chromophore	chromophore	NN
cord-001835-0s7ok4uw	2959	30	.	.	.
cord-001835-0s7ok4uw	2960	1	In	in	IN
cord-001835-0s7ok4uw	2960	2	this	this	DT
cord-001835-0s7ok4uw	2960	3	way	way	NN
cord-001835-0s7ok4uw	2960	4	,	,	,
cord-001835-0s7ok4uw	2960	5	a	a	DT
cord-001835-0s7ok4uw	2960	6	softer	softer	RBR
cord-001835-0s7ok4uw	2960	7	active	active	JJ
cord-001835-0s7ok4uw	2960	8	site	site	NN
cord-001835-0s7ok4uw	2960	9	appears	appear	VBZ
cord-001835-0s7ok4uw	2960	10	to	to	TO
cord-001835-0s7ok4uw	2960	11	be	be	VB
cord-001835-0s7ok4uw	2960	12	coupled	couple	VBN
cord-001835-0s7ok4uw	2960	13	to	to	IN
cord-001835-0s7ok4uw	2960	14	a	a	DT
cord-001835-0s7ok4uw	2960	15	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2960	16	involving	involve	VBG
cord-001835-0s7ok4uw	2960	17	concerted	concerted	JJ
cord-001835-0s7ok4uw	2960	18	carbon	carbon	NN
cord-001835-0s7ok4uw	2960	19	acid	acid	NN
cord-001835-0s7ok4uw	2960	20	deprotonation	deprotonation	NN
cord-001835-0s7ok4uw	2960	21	and	and	CC
cord-001835-0s7ok4uw	2960	22	betaelimination	betaelimination	NN
cord-001835-0s7ok4uw	2960	23	.	.	.
cord-001835-0s7ok4uw	2961	1	Dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2961	2	-	-	HYPH
cord-001835-0s7ok4uw	2961	3	driven	drive	VBN
cord-001835-0s7ok4uw	2961	4	hinge	hinge	NN
cord-001835-0s7ok4uw	2961	5	migration	migration	NN
cord-001835-0s7ok4uw	2961	6	may	may	MD
cord-001835-0s7ok4uw	2961	7	represent	represent	VB
cord-001835-0s7ok4uw	2961	8	a	a	DT
cord-001835-0s7ok4uw	2961	9	more	more	RBR
cord-001835-0s7ok4uw	2961	10	general	general	JJ
cord-001835-0s7ok4uw	2961	11	platform	platform	NN
cord-001835-0s7ok4uw	2961	12	for	for	IN
cord-001835-0s7ok4uw	2961	13	the	the	DT
cord-001835-0s7ok4uw	2961	14	evolution	evolution	NN
cord-001835-0s7ok4uw	2961	15	of	of	IN
cord-001835-0s7ok4uw	2961	16	novel	novel	JJ
cord-001835-0s7ok4uw	2961	17	enzyme	enzyme	NN
cord-001835-0s7ok4uw	2961	18	activities	activity	NNS
cord-001835-0s7ok4uw	2961	19	by	by	IN
cord-001835-0s7ok4uw	2961	20	tuning	tune	VBG
cord-001835-0s7ok4uw	2961	21	motions	motion	NNS
cord-001835-0s7ok4uw	2961	22	in	in	IN
cord-001835-0s7ok4uw	2961	23	the	the	DT
cord-001835-0s7ok4uw	2961	24	active	active	JJ
cord-001835-0s7ok4uw	2961	25	site	site	NN
cord-001835-0s7ok4uw	2961	26	.	.	.
cord-001835-0s7ok4uw	2962	1	The	the	DT
cord-001835-0s7ok4uw	2962	2	binding	binding	NN
cord-001835-0s7ok4uw	2962	3	of	of	IN
cord-001835-0s7ok4uw	2962	4	an	an	DT
cord-001835-0s7ok4uw	2962	5	agonist	agonist	NN
cord-001835-0s7ok4uw	2962	6	to	to	IN
cord-001835-0s7ok4uw	2962	7	a	a	DT
cord-001835-0s7ok4uw	2962	8	GPCR	GPCR	NNP
cord-001835-0s7ok4uw	2962	9	causes	cause	VBZ
cord-001835-0s7ok4uw	2962	10	a	a	DT
cord-001835-0s7ok4uw	2962	11	conformational	conformational	JJ
cord-001835-0s7ok4uw	2962	12	change	change	NN
cord-001835-0s7ok4uw	2962	13	in	in	IN
cord-001835-0s7ok4uw	2962	14	the	the	DT
cord-001835-0s7ok4uw	2962	15	receptor	receptor	NN
cord-001835-0s7ok4uw	2962	16	that	that	WDT
cord-001835-0s7ok4uw	2962	17	leads	lead	VBZ
cord-001835-0s7ok4uw	2962	18	to	to	IN
cord-001835-0s7ok4uw	2962	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2962	20	activated	activate	VBN
cord-001835-0s7ok4uw	2962	21	functional	functional	JJ
cord-001835-0s7ok4uw	2962	22	state	state	NN
cord-001835-0s7ok4uw	2962	23	.	.	.
cord-001835-0s7ok4uw	2963	1	Rhodopsin	Rhodopsin	NNP
cord-001835-0s7ok4uw	2963	2	,	,	,
cord-001835-0s7ok4uw	2963	3	the	the	DT
cord-001835-0s7ok4uw	2963	4	membrane	membrane	NN
cord-001835-0s7ok4uw	2963	5	receptor	receptor	NN
cord-001835-0s7ok4uw	2963	6	responsible	responsible	JJ
cord-001835-0s7ok4uw	2963	7	for	for	IN
cord-001835-0s7ok4uw	2963	8	photoreception	photoreception	NN
cord-001835-0s7ok4uw	2963	9	in	in	IN
cord-001835-0s7ok4uw	2963	10	the	the	DT
cord-001835-0s7ok4uw	2963	11	vertebrate	vertebrate	JJ
cord-001835-0s7ok4uw	2963	12	retina	retina	NN
cord-001835-0s7ok4uw	2963	13	,	,	,
cord-001835-0s7ok4uw	2963	14	is	be	VBZ
cord-001835-0s7ok4uw	2963	15	a	a	DT
cord-001835-0s7ok4uw	2963	16	prototypical	prototypical	JJ
cord-001835-0s7ok4uw	2963	17	GPCR	GPCR	NNP
cord-001835-0s7ok4uw	2963	18	and	and	CC
cord-001835-0s7ok4uw	2963	19	has	have	VBZ
cord-001835-0s7ok4uw	2963	20	been	be	VBN
cord-001835-0s7ok4uw	2963	21	extensively	extensively	RB
cord-001835-0s7ok4uw	2963	22	used	use	VBN
cord-001835-0s7ok4uw	2963	23	in	in	IN
cord-001835-0s7ok4uw	2963	24	structural	structural	JJ
cord-001835-0s7ok4uw	2963	25	,	,	,
cord-001835-0s7ok4uw	2963	26	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	2963	27	and	and	CC
cord-001835-0s7ok4uw	2963	28	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	2963	29	studies	study	NNS
cord-001835-0s7ok4uw	2963	30	of	of	IN
cord-001835-0s7ok4uw	2963	31	this	this	DT
cord-001835-0s7ok4uw	2963	32	class	class	NN
cord-001835-0s7ok4uw	2963	33	of	of	IN
cord-001835-0s7ok4uw	2963	34	receptors	receptor	NNS
cord-001835-0s7ok4uw	2963	35	.	.	.
cord-001835-0s7ok4uw	2964	1	Different	different	JJ
cord-001835-0s7ok4uw	2964	2	small	small	JJ
cord-001835-0s7ok4uw	2964	3	molecules	molecule	NNS
cord-001835-0s7ok4uw	2964	4	have	have	VBP
cord-001835-0s7ok4uw	2964	5	been	be	VBN
cord-001835-0s7ok4uw	2964	6	described	describe	VBN
cord-001835-0s7ok4uw	2964	7	to	to	TO
cord-001835-0s7ok4uw	2964	8	be	be	VB
cord-001835-0s7ok4uw	2964	9	capable	capable	JJ
cord-001835-0s7ok4uw	2964	10	of	of	IN
cord-001835-0s7ok4uw	2964	11	binding	bind	VBG
cord-001835-0s7ok4uw	2964	12	to	to	IN
cord-001835-0s7ok4uw	2964	13	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2964	14	.	.	.
cord-001835-0s7ok4uw	2965	1	In	in	IN
cord-001835-0s7ok4uw	2965	2	addition	addition	NN
cord-001835-0s7ok4uw	2965	3	,	,	,
cord-001835-0s7ok4uw	2965	4	mutations	mutation	NNS
cord-001835-0s7ok4uw	2965	5	in	in	IN
cord-001835-0s7ok4uw	2965	6	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2965	7	have	have	VBP
cord-001835-0s7ok4uw	2965	8	been	be	VBN
cord-001835-0s7ok4uw	2965	9	associated	associate	VBN
cord-001835-0s7ok4uw	2965	10	with	with	IN
cord-001835-0s7ok4uw	2965	11	retinal	retinal	JJ
cord-001835-0s7ok4uw	2965	12	diseases	disease	NNS
cord-001835-0s7ok4uw	2965	13	and	and	CC
cord-001835-0s7ok4uw	2965	14	efforts	effort	NNS
cord-001835-0s7ok4uw	2965	15	have	have	VBP
cord-001835-0s7ok4uw	2965	16	been	be	VBN
cord-001835-0s7ok4uw	2965	17	carried	carry	VBN
cord-001835-0s7ok4uw	2965	18	out	out	RP
cord-001835-0s7ok4uw	2965	19	in	in	IN
cord-001835-0s7ok4uw	2965	20	order	order	NN
cord-001835-0s7ok4uw	2965	21	to	to	TO
cord-001835-0s7ok4uw	2965	22	find	find	VB
cord-001835-0s7ok4uw	2965	23	potential	potential	JJ
cord-001835-0s7ok4uw	2965	24	ligands	ligand	NNS
cord-001835-0s7ok4uw	2965	25	that	that	WDT
cord-001835-0s7ok4uw	2965	26	can	can	MD
cord-001835-0s7ok4uw	2965	27	offset	offset	VB
cord-001835-0s7ok4uw	2965	28	the	the	DT
cord-001835-0s7ok4uw	2965	29	effect	effect	NN
cord-001835-0s7ok4uw	2965	30	of	of	IN
cord-001835-0s7ok4uw	2965	31	these	these	DT
cord-001835-0s7ok4uw	2965	32	mutations	mutation	NNS
cord-001835-0s7ok4uw	2965	33	.	.	.
cord-001835-0s7ok4uw	2966	1	Cyanidins	Cyanidins	NNP
cord-001835-0s7ok4uw	2966	2	,	,	,
cord-001835-0s7ok4uw	2966	3	a	a	DT
cord-001835-0s7ok4uw	2966	4	group	group	NN
cord-001835-0s7ok4uw	2966	5	of	of	IN
cord-001835-0s7ok4uw	2966	6	flavonoids	flavonoid	NNS
cord-001835-0s7ok4uw	2966	7	within	within	IN
cord-001835-0s7ok4uw	2966	8	the	the	DT
cord-001835-0s7ok4uw	2966	9	larger	large	JJR
cord-001835-0s7ok4uw	2966	10	family	family	NN
cord-001835-0s7ok4uw	2966	11	of	of	IN
cord-001835-0s7ok4uw	2966	12	polyphenols	polyphenol	NNS
cord-001835-0s7ok4uw	2966	13	,	,	,
cord-001835-0s7ok4uw	2966	14	have	have	VBP
cord-001835-0s7ok4uw	2966	15	been	be	VBN
cord-001835-0s7ok4uw	2966	16	reported	report	VBN
cord-001835-0s7ok4uw	2966	17	to	to	TO
cord-001835-0s7ok4uw	2966	18	stimulate	stimulate	VB
cord-001835-0s7ok4uw	2966	19	chromophore	chromophore	NN
cord-001835-0s7ok4uw	2966	20	regeneration	regeneration	NN
cord-001835-0s7ok4uw	2966	21	of	of	IN
cord-001835-0s7ok4uw	2966	22	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2966	23	by	by	IN
cord-001835-0s7ok4uw	2966	24	means	mean	NNS
cord-001835-0s7ok4uw	2966	25	of	of	IN
cord-001835-0s7ok4uw	2966	26	the	the	DT
cord-001835-0s7ok4uw	2966	27	formation	formation	NN
cord-001835-0s7ok4uw	2966	28	of	of	IN
cord-001835-0s7ok4uw	2966	29	regeneration	regeneration	NN
cord-001835-0s7ok4uw	2966	30	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	2966	31	.	.	.
cord-001835-0s7ok4uw	2967	1	The	the	DT
cord-001835-0s7ok4uw	2967	2	aim	aim	NN
cord-001835-0s7ok4uw	2967	3	of	of	IN
cord-001835-0s7ok4uw	2967	4	the	the	DT
cord-001835-0s7ok4uw	2967	5	current	current	JJ
cord-001835-0s7ok4uw	2967	6	study	study	NN
cord-001835-0s7ok4uw	2967	7	was	be	VBD
cord-001835-0s7ok4uw	2967	8	to	to	TO
cord-001835-0s7ok4uw	2967	9	evaluate	evaluate	VB
cord-001835-0s7ok4uw	2967	10	the	the	DT
cord-001835-0s7ok4uw	2967	11	effect	effect	NN
cord-001835-0s7ok4uw	2967	12	of	of	IN
cord-001835-0s7ok4uw	2967	13	the	the	DT
cord-001835-0s7ok4uw	2967	14	flavonoid	flavonoid	NN
cord-001835-0s7ok4uw	2967	15	quercetin	quercetin	NN
cord-001835-0s7ok4uw	2967	16	on	on	IN
cord-001835-0s7ok4uw	2967	17	the	the	DT
cord-001835-0s7ok4uw	2967	18	conformational	conformational	JJ
cord-001835-0s7ok4uw	2967	19	properties	property	NNS
cord-001835-0s7ok4uw	2967	20	of	of	IN
cord-001835-0s7ok4uw	2967	21	both	both	DT
cord-001835-0s7ok4uw	2967	22	native	native	JJ
cord-001835-0s7ok4uw	2967	23	bovine	bovine	JJ
cord-001835-0s7ok4uw	2967	24	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2967	25	and	and	CC
cord-001835-0s7ok4uw	2967	26	heterologously	heterologously	NNP
cord-001835-0s7ok4uw	2967	27	expressed	express	VBD
cord-001835-0s7ok4uw	2967	28	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	2967	29	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2967	30	.	.	.
cord-001835-0s7ok4uw	2968	1	Rhodopsin	Rhodopsin	NNP
cord-001835-0s7ok4uw	2968	2	was	be	VBD
cord-001835-0s7ok4uw	2968	3	purified	purify	VBN
cord-001835-0s7ok4uw	2968	4	from	from	IN
cord-001835-0s7ok4uw	2968	5	bovine	bovine	JJ
cord-001835-0s7ok4uw	2968	6	retinas	retina	NNS
cord-001835-0s7ok4uw	2968	7	by	by	IN
cord-001835-0s7ok4uw	2968	8	immunoaffinity	immunoaffinity	NN
cord-001835-0s7ok4uw	2968	9	chromatography	chromatography	NN
cord-001835-0s7ok4uw	2968	10	,	,	,
cord-001835-0s7ok4uw	2968	11	and	and	CC
cord-001835-0s7ok4uw	2968	12	photobleaching	photobleaching	NN
cord-001835-0s7ok4uw	2968	13	,	,	,
cord-001835-0s7ok4uw	2968	14	thermal	thermal	JJ
cord-001835-0s7ok4uw	2968	15	stability	stability	NN
cord-001835-0s7ok4uw	2968	16	,	,	,
cord-001835-0s7ok4uw	2968	17	metarhodopsin	metarhodopsin	NNP
cord-001835-0s7ok4uw	2968	18	II	ii	CD
cord-001835-0s7ok4uw	2968	19	decay	decay	NN
cord-001835-0s7ok4uw	2968	20	and	and	CC
cord-001835-0s7ok4uw	2968	21	chromophore	chromophore	NN
cord-001835-0s7ok4uw	2968	22	regeneration	regeneration	NN
cord-001835-0s7ok4uw	2968	23	assays	assay	NNS
cord-001835-0s7ok4uw	2968	24	were	be	VBD
cord-001835-0s7ok4uw	2968	25	carried	carry	VBN
cord-001835-0s7ok4uw	2968	26	out	out	RP
cord-001835-0s7ok4uw	2968	27	in	in	IN
cord-001835-0s7ok4uw	2968	28	the	the	DT
cord-001835-0s7ok4uw	2968	29	absence	absence	NN
cord-001835-0s7ok4uw	2968	30	or	or	CC
cord-001835-0s7ok4uw	2968	31	in	in	IN
cord-001835-0s7ok4uw	2968	32	the	the	DT
cord-001835-0s7ok4uw	2968	33	presence	presence	NN
cord-001835-0s7ok4uw	2968	34	of	of	IN
cord-001835-0s7ok4uw	2968	35	1mM	1mm	CD
cord-001835-0s7ok4uw	2968	36	quercetin	quercetin	NN
cord-001835-0s7ok4uw	2968	37	.	.	.
cord-001835-0s7ok4uw	2969	1	For	for	IN
cord-001835-0s7ok4uw	2969	2	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	2969	3	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2969	4	,	,	,
cord-001835-0s7ok4uw	2969	5	a	a	DT
cord-001835-0s7ok4uw	2969	6	plasmid	plasmid	NN
cord-001835-0s7ok4uw	2969	7	encoding	encode	VBG
cord-001835-0s7ok4uw	2969	8	wild	wild	JJ
cord-001835-0s7ok4uw	2969	9	-	-	HYPH
cord-001835-0s7ok4uw	2969	10	type	type	NN
cord-001835-0s7ok4uw	2969	11	opsin	opsin	NN
cord-001835-0s7ok4uw	2969	12	was	be	VBD
cord-001835-0s7ok4uw	2969	13	transfected	transfecte	VBN
cord-001835-0s7ok4uw	2969	14	into	into	IN
cord-001835-0s7ok4uw	2969	15	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	2969	16	COS-1	COS-1	NNP
cord-001835-0s7ok4uw	2969	17	cells	cell	NNS
cord-001835-0s7ok4uw	2969	18	,	,	,
cord-001835-0s7ok4uw	2969	19	in	in	IN
cord-001835-0s7ok4uw	2969	20	the	the	DT
cord-001835-0s7ok4uw	2969	21	absence	absence	NN
cord-001835-0s7ok4uw	2969	22	or	or	CC
cord-001835-0s7ok4uw	2969	23	in	in	IN
cord-001835-0s7ok4uw	2969	24	the	the	DT
cord-001835-0s7ok4uw	2969	25	presence	presence	NN
cord-001835-0s7ok4uw	2969	26	of	of	IN
cord-001835-0s7ok4uw	2969	27	1mM	1mm	CD
cord-001835-0s7ok4uw	2969	28	quercetin	quercetin	NNS
cord-001835-0s7ok4uw	2969	29	,	,	,
cord-001835-0s7ok4uw	2969	30	harvested	harvest	VBN
cord-001835-0s7ok4uw	2969	31	,	,	,
cord-001835-0s7ok4uw	2969	32	regenerated	regenerate	VBN
cord-001835-0s7ok4uw	2969	33	with	with	IN
cord-001835-0s7ok4uw	2969	34	11-cis	11-cis	CD
cord-001835-0s7ok4uw	2969	35	-	-	HYPH
cord-001835-0s7ok4uw	2969	36	retinal	retinal	JJ
cord-001835-0s7ok4uw	2969	37	,	,	,
cord-001835-0s7ok4uw	2969	38	or	or	CC
cord-001835-0s7ok4uw	2969	39	9-cis	9-cis	JJ
cord-001835-0s7ok4uw	2969	40	-	-	HYPH
cord-001835-0s7ok4uw	2969	41	retinal	retinal	JJ
cord-001835-0s7ok4uw	2969	42	,	,	,
cord-001835-0s7ok4uw	2969	43	and	and	CC
cord-001835-0s7ok4uw	2969	44	subsequently	subsequently	RB
cord-001835-0s7ok4uw	2969	45	purified	purify	VBN
cord-001835-0s7ok4uw	2969	46	in	in	IN
cord-001835-0s7ok4uw	2969	47	dodecyl	dodecyl	NNP
cord-001835-0s7ok4uw	2969	48	maltoside	maltoside	NNP
cord-001835-0s7ok4uw	2969	49	solution	solution	NN
cord-001835-0s7ok4uw	2969	50	.	.	.
cord-001835-0s7ok4uw	2970	1	No	no	DT
cord-001835-0s7ok4uw	2970	2	differences	difference	NNS
cord-001835-0s7ok4uw	2970	3	in	in	IN
cord-001835-0s7ok4uw	2970	4	photobleaching	photobleaching	NN
cord-001835-0s7ok4uw	2970	5	behavior	behavior	NN
cord-001835-0s7ok4uw	2970	6	,	,	,
cord-001835-0s7ok4uw	2970	7	upon	upon	IN
cord-001835-0s7ok4uw	2970	8	illumination	illumination	NN
cord-001835-0s7ok4uw	2970	9	,	,	,
cord-001835-0s7ok4uw	2970	10	could	could	MD
cord-001835-0s7ok4uw	2970	11	be	be	VB
cord-001835-0s7ok4uw	2970	12	detected	detect	VBN
cord-001835-0s7ok4uw	2970	13	in	in	IN
cord-001835-0s7ok4uw	2970	14	the	the	DT
cord-001835-0s7ok4uw	2970	15	purified	purify	VBN
cord-001835-0s7ok4uw	2970	16	quercetin	quercetin	NN
cord-001835-0s7ok4uw	2970	17	-	-	HYPH
cord-001835-0s7ok4uw	2970	18	containing	contain	VBG
cord-001835-0s7ok4uw	2970	19	samples	sample	NNS
cord-001835-0s7ok4uw	2970	20	compared	compare	VBN
cord-001835-0s7ok4uw	2970	21	to	to	IN
cord-001835-0s7ok4uw	2970	22	those	those	DT
cord-001835-0s7ok4uw	2970	23	in	in	IN
cord-001835-0s7ok4uw	2970	24	the	the	DT
cord-001835-0s7ok4uw	2970	25	absence	absence	NN
cord-001835-0s7ok4uw	2970	26	of	of	IN
cord-001835-0s7ok4uw	2970	27	this	this	DT
cord-001835-0s7ok4uw	2970	28	flavonoid	flavonoid	NN
cord-001835-0s7ok4uw	2970	29	.	.	.
cord-001835-0s7ok4uw	2971	1	In	in	IN
cord-001835-0s7ok4uw	2971	2	the	the	DT
cord-001835-0s7ok4uw	2971	3	case	case	NN
cord-001835-0s7ok4uw	2971	4	of	of	IN
cord-001835-0s7ok4uw	2971	5	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2971	6	,	,	,
cord-001835-0s7ok4uw	2971	7	and	and	CC
cord-001835-0s7ok4uw	2971	8	the	the	DT
cord-001835-0s7ok4uw	2971	9	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	2971	10	wild	wild	JJ
cord-001835-0s7ok4uw	2971	11	-	-	HYPH
cord-001835-0s7ok4uw	2971	12	type	type	NN
cord-001835-0s7ok4uw	2971	13	protein	protein	NN
cord-001835-0s7ok4uw	2971	14	regenerated	regenerate	VBN
cord-001835-0s7ok4uw	2971	15	with	with	IN
cord-001835-0s7ok4uw	2971	16	11-cis	11-cis	CD
cord-001835-0s7ok4uw	2971	17	-	-	HYPH
cord-001835-0s7ok4uw	2971	18	retinal	retinal	JJ
cord-001835-0s7ok4uw	2971	19	,	,	,
cord-001835-0s7ok4uw	2971	20	quercetin	quercetin	JJ
cord-001835-0s7ok4uw	2971	21	did	do	VBD
cord-001835-0s7ok4uw	2971	22	not	not	RB
cord-001835-0s7ok4uw	2971	23	significantly	significantly	RB
cord-001835-0s7ok4uw	2971	24	alter	alter	VB
cord-001835-0s7ok4uw	2971	25	the	the	DT
cord-001835-0s7ok4uw	2971	26	thermal	thermal	JJ
cord-001835-0s7ok4uw	2971	27	stability	stability	NN
cord-001835-0s7ok4uw	2971	28	and	and	CC
cord-001835-0s7ok4uw	2971	29	rate	rate	NN
cord-001835-0s7ok4uw	2971	30	of	of	IN
cord-001835-0s7ok4uw	2971	31	regeneration	regeneration	NN
cord-001835-0s7ok4uw	2971	32	of	of	IN
cord-001835-0s7ok4uw	2971	33	the	the	DT
cord-001835-0s7ok4uw	2971	34	purified	purify	VBN
cord-001835-0s7ok4uw	2971	35	proteins	protein	NNS
cord-001835-0s7ok4uw	2971	36	under	under	IN
cord-001835-0s7ok4uw	2971	37	our	-PRON-	PRP$
cord-001835-0s7ok4uw	2971	38	experimental	experimental	JJ
cord-001835-0s7ok4uw	2971	39	conditions	condition	NNS
cord-001835-0s7ok4uw	2971	40	.	.	.
cord-001835-0s7ok4uw	2972	1	However	however	RB
cord-001835-0s7ok4uw	2972	2	,	,	,
cord-001835-0s7ok4uw	2972	3	a	a	DT
cord-001835-0s7ok4uw	2972	4	two	two	CD
cord-001835-0s7ok4uw	2972	5	-	-	HYPH
cord-001835-0s7ok4uw	2972	6	fold	fold	JJ
cord-001835-0s7ok4uw	2972	7	increase	increase	NN
cord-001835-0s7ok4uw	2972	8	in	in	IN
cord-001835-0s7ok4uw	2972	9	the	the	DT
cord-001835-0s7ok4uw	2972	10	thermal	thermal	JJ
cord-001835-0s7ok4uw	2972	11	stability	stability	NN
cord-001835-0s7ok4uw	2972	12	and	and	CC
cord-001835-0s7ok4uw	2972	13	a	a	DT
cord-001835-0s7ok4uw	2972	14	40	40	CD
cord-001835-0s7ok4uw	2972	15	%	%	NN
cord-001835-0s7ok4uw	2972	16	increase	increase	NN
cord-001835-0s7ok4uw	2972	17	in	in	IN
cord-001835-0s7ok4uw	2972	18	chromophore	chromophore	NN
cord-001835-0s7ok4uw	2972	19	regeneration	regeneration	NN
cord-001835-0s7ok4uw	2972	20	were	be	VBD
cord-001835-0s7ok4uw	2972	21	observed	observe	VBN
cord-001835-0s7ok4uw	2972	22	for	for	IN
cord-001835-0s7ok4uw	2972	23	the	the	DT
cord-001835-0s7ok4uw	2972	24	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	2972	25	wild	wild	JJ
cord-001835-0s7ok4uw	2972	26	-	-	HYPH
cord-001835-0s7ok4uw	2972	27	type	type	NN
cord-001835-0s7ok4uw	2972	28	protein	protein	NN
cord-001835-0s7ok4uw	2972	29	regenerated	regenerate	VBN
cord-001835-0s7ok4uw	2972	30	with	with	IN
cord-001835-0s7ok4uw	2972	31	9-cis	9-cis	JJ
cord-001835-0s7ok4uw	2972	32	-	-	HYPH
cord-001835-0s7ok4uw	2972	33	retinal	retinal	JJ
cord-001835-0s7ok4uw	2972	34	in	in	IN
cord-001835-0s7ok4uw	2972	35	the	the	DT
cord-001835-0s7ok4uw	2972	36	presence	presence	NN
cord-001835-0s7ok4uw	2972	37	of	of	IN
cord-001835-0s7ok4uw	2972	38	quercetin	quercetin	NN
cord-001835-0s7ok4uw	2972	39	.	.	.
cord-001835-0s7ok4uw	2973	1	In	in	IN
cord-001835-0s7ok4uw	2973	2	contrast	contrast	NN
cord-001835-0s7ok4uw	2973	3	,	,	,
cord-001835-0s7ok4uw	2973	4	the	the	DT
cord-001835-0s7ok4uw	2973	5	presence	presence	NN
cord-001835-0s7ok4uw	2973	6	of	of	IN
cord-001835-0s7ok4uw	2973	7	quercetin	quercetin	NNS
cord-001835-0s7ok4uw	2973	8	did	do	VBD
cord-001835-0s7ok4uw	2973	9	not	not	RB
cord-001835-0s7ok4uw	2973	10	alter	alter	VB
cord-001835-0s7ok4uw	2973	11	the	the	DT
cord-001835-0s7ok4uw	2973	12	electrophoretic	electrophoretic	JJ
cord-001835-0s7ok4uw	2973	13	and	and	CC
cord-001835-0s7ok4uw	2973	14	basic	basic	JJ
cord-001835-0s7ok4uw	2973	15	spectroscopic	spectroscopic	JJ
cord-001835-0s7ok4uw	2973	16	properties	property	NNS
cord-001835-0s7ok4uw	2973	17	of	of	IN
cord-001835-0s7ok4uw	2973	18	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2973	19	,	,	,
cord-001835-0s7ok4uw	2973	20	or	or	CC
cord-001835-0s7ok4uw	2973	21	those	those	DT
cord-001835-0s7ok4uw	2973	22	of	of	IN
cord-001835-0s7ok4uw	2973	23	the	the	DT
cord-001835-0s7ok4uw	2973	24	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	2973	25	wild	wild	JJ
cord-001835-0s7ok4uw	2973	26	-	-	HYPH
cord-001835-0s7ok4uw	2973	27	type	type	NN
cord-001835-0s7ok4uw	2973	28	protein	protein	NN
cord-001835-0s7ok4uw	2973	29	,	,	,
cord-001835-0s7ok4uw	2973	30	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2973	31	no	no	DT
cord-001835-0s7ok4uw	2973	32	important	important	JJ
cord-001835-0s7ok4uw	2973	33	structural	structural	JJ
cord-001835-0s7ok4uw	2973	34	alterations	alteration	NNS
cord-001835-0s7ok4uw	2973	35	as	as	IN
cord-001835-0s7ok4uw	2973	36	a	a	DT
cord-001835-0s7ok4uw	2973	37	result	result	NN
cord-001835-0s7ok4uw	2973	38	of	of	IN
cord-001835-0s7ok4uw	2973	39	quercetin	quercetin	NN
cord-001835-0s7ok4uw	2973	40	binding	bind	VBG
cord-001835-0s7ok4uw	2973	41	to	to	IN
cord-001835-0s7ok4uw	2973	42	the	the	DT
cord-001835-0s7ok4uw	2973	43	receptor	receptor	NN
cord-001835-0s7ok4uw	2973	44	.	.	.
cord-001835-0s7ok4uw	2974	1	The	the	DT
cord-001835-0s7ok4uw	2974	2	positive	positive	JJ
cord-001835-0s7ok4uw	2974	3	effect	effect	NN
cord-001835-0s7ok4uw	2974	4	of	of	IN
cord-001835-0s7ok4uw	2974	5	quercetin	quercetin	NN
cord-001835-0s7ok4uw	2974	6	on	on	IN
cord-001835-0s7ok4uw	2974	7	the	the	DT
cord-001835-0s7ok4uw	2974	8	stability	stability	NN
cord-001835-0s7ok4uw	2974	9	,	,	,
cord-001835-0s7ok4uw	2974	10	and	and	CC
cord-001835-0s7ok4uw	2974	11	chromophore	chromophore	NN
cord-001835-0s7ok4uw	2974	12	regeneration	regeneration	NN
cord-001835-0s7ok4uw	2974	13	of	of	IN
cord-001835-0s7ok4uw	2974	14	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2974	15	,	,	,
cord-001835-0s7ok4uw	2974	16	could	could	MD
cord-001835-0s7ok4uw	2974	17	be	be	VB
cord-001835-0s7ok4uw	2974	18	potentially	potentially	RB
cord-001835-0s7ok4uw	2974	19	used	use	VBN
cord-001835-0s7ok4uw	2974	20	to	to	TO
cord-001835-0s7ok4uw	2974	21	counteract	counteract	VB
cord-001835-0s7ok4uw	2974	22	the	the	DT
cord-001835-0s7ok4uw	2974	23	effect	effect	NN
cord-001835-0s7ok4uw	2974	24	of	of	IN
cord-001835-0s7ok4uw	2974	25	naturally	naturally	RB
cord-001835-0s7ok4uw	2974	26	-	-	HYPH
cord-001835-0s7ok4uw	2974	27	occurring	occur	VBG
cord-001835-0s7ok4uw	2974	28	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	2974	29	mutations	mutation	NNS
cord-001835-0s7ok4uw	2974	30	in	in	IN
cord-001835-0s7ok4uw	2974	31	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2974	32	.	.	.
cord-001835-0s7ok4uw	2975	1	Thus	thus	RB
cord-001835-0s7ok4uw	2975	2	,	,	,
cord-001835-0s7ok4uw	2975	3	quercetin	quercetin	NN
cord-001835-0s7ok4uw	2975	4	could	could	MD
cord-001835-0s7ok4uw	2975	5	help	help	VB
cord-001835-0s7ok4uw	2975	6	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	2975	7	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2975	8	mutants	mutant	NNS
cord-001835-0s7ok4uw	2975	9	associated	associate	VBN
cord-001835-0s7ok4uw	2975	10	with	with	IN
cord-001835-0s7ok4uw	2975	11	retinal	retinal	JJ
cord-001835-0s7ok4uw	2975	12	diseases	disease	NNS
cord-001835-0s7ok4uw	2975	13	such	such	JJ
cord-001835-0s7ok4uw	2975	14	as	as	IN
cord-001835-0s7ok4uw	2975	15	retinitis	retinitis	NN
cord-001835-0s7ok4uw	2975	16	pigmentosa	pigmentosa	NN
cord-001835-0s7ok4uw	2975	17	.	.	.
cord-001835-0s7ok4uw	2976	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	2976	2	,	,	,
cord-001835-0s7ok4uw	2976	3	docking	docking	NN
cord-001835-0s7ok4uw	2976	4	of	of	IN
cord-001835-0s7ok4uw	2976	5	the	the	DT
cord-001835-0s7ok4uw	2976	6	ligand	ligand	NN
cord-001835-0s7ok4uw	2976	7	,	,	,
cord-001835-0s7ok4uw	2976	8	carried	carry	VBN
cord-001835-0s7ok4uw	2976	9	out	out	RP
cord-001835-0s7ok4uw	2976	10	on	on	IN
cord-001835-0s7ok4uw	2976	11	the	the	DT
cord-001835-0s7ok4uw	2976	12	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	2976	13	structure	structure	NN
cord-001835-0s7ok4uw	2976	14	of	of	IN
cord-001835-0s7ok4uw	2976	15	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	2976	16	(	(	-LRB-
cord-001835-0s7ok4uw	2976	17	entry	entry	NN
cord-001835-0s7ok4uw	2976	18	1GZM	1gzm	CD
cord-001835-0s7ok4uw	2976	19	)	)	-RRB-
cord-001835-0s7ok4uw	2976	20	,	,	,
cord-001835-0s7ok4uw	2976	21	reveals	reveal	VBZ
cord-001835-0s7ok4uw	2976	22	several	several	JJ
cord-001835-0s7ok4uw	2976	23	favorable	favorable	JJ
cord-001835-0s7ok4uw	2976	24	sites	site	NNS
cord-001835-0s7ok4uw	2976	25	for	for	IN
cord-001835-0s7ok4uw	2976	26	quercetin	quercetin	JJ
cord-001835-0s7ok4uw	2976	27	binding	binding	NN
cord-001835-0s7ok4uw	2976	28	.	.	.
cord-001835-0s7ok4uw	2977	1	One	one	CD
cord-001835-0s7ok4uw	2977	2	of	of	IN
cord-001835-0s7ok4uw	2977	3	this	this	DT
cord-001835-0s7ok4uw	2977	4	would	would	MD
cord-001835-0s7ok4uw	2977	5	be	be	VB
cord-001835-0s7ok4uw	2977	6	compatible	compatible	JJ
cord-001835-0s7ok4uw	2977	7	with	with	IN
cord-001835-0s7ok4uw	2977	8	9-cis	9-cis	JJ
cord-001835-0s7ok4uw	2977	9	-	-	HYPH
cord-001835-0s7ok4uw	2977	10	retinal	retinal	JJ
cord-001835-0s7ok4uw	2977	11	suggesting	suggest	VBG
cord-001835-0s7ok4uw	2977	12	a	a	DT
cord-001835-0s7ok4uw	2977	13	complementary	complementary	JJ
cord-001835-0s7ok4uw	2977	14	binding	binding	NN
cord-001835-0s7ok4uw	2977	15	to	to	IN
cord-001835-0s7ok4uw	2977	16	the	the	DT
cord-001835-0s7ok4uw	2977	17	receptor	receptor	NN
cord-001835-0s7ok4uw	2977	18	of	of	IN
cord-001835-0s7ok4uw	2977	19	this	this	DT
cord-001835-0s7ok4uw	2977	20	isomer	isomer	NN
cord-001835-0s7ok4uw	2977	21	which	which	WDT
cord-001835-0s7ok4uw	2977	22	would	would	MD
cord-001835-0s7ok4uw	2977	23	not	not	RB
cord-001835-0s7ok4uw	2977	24	be	be	VB
cord-001835-0s7ok4uw	2977	25	compatible	compatible	JJ
cord-001835-0s7ok4uw	2977	26	with	with	IN
cord-001835-0s7ok4uw	2977	27	11-cis	11-cis	CD
cord-001835-0s7ok4uw	2977	28	-	-	HYPH
cord-001835-0s7ok4uw	2977	29	retinal	retinal	JJ
cord-001835-0s7ok4uw	2977	30	binding	binding	NN
cord-001835-0s7ok4uw	2977	31	.	.	.
cord-001835-0s7ok4uw	2978	1	Identification	identification	NN
cord-001835-0s7ok4uw	2978	2	of	of	IN
cord-001835-0s7ok4uw	2978	3	prospective	prospective	JJ
cord-001835-0s7ok4uw	2978	4	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2978	5	sites	site	NNS
cord-001835-0s7ok4uw	2978	6	of	of	IN
cord-001835-0s7ok4uw	2978	7	p38	p38	CD
cord-001835-0s7ok4uw	2978	8	by	by	IN
cord-001835-0s7ok4uw	2978	9	computational	computational	JJ
cord-001835-0s7ok4uw	2978	10	methods	method	NNS
cord-001835-0s7ok4uw	2978	11	Protein	protein	NN
cord-001835-0s7ok4uw	2978	12	function	function	NN
cord-001835-0s7ok4uw	2978	13	is	be	VBZ
cord-001835-0s7ok4uw	2978	14	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	2978	15	associated	associate	VBN
cord-001835-0s7ok4uw	2978	16	with	with	IN
cord-001835-0s7ok4uw	2978	17	structural	structural	JJ
cord-001835-0s7ok4uw	2978	18	flexibility	flexibility	NN
cord-001835-0s7ok4uw	2978	19	,	,	,
cord-001835-0s7ok4uw	2978	20	so	so	IN
cord-001835-0s7ok4uw	2978	21	that	that	IN
cord-001835-0s7ok4uw	2978	22	understanding	understand	VBG
cord-001835-0s7ok4uw	2978	23	the	the	DT
cord-001835-0s7ok4uw	2978	24	functional	functional	JJ
cord-001835-0s7ok4uw	2978	25	properties	property	NNS
cord-001835-0s7ok4uw	2978	26	of	of	IN
cord-001835-0s7ok4uw	2978	27	proteins	protein	NNS
cord-001835-0s7ok4uw	2978	28	requires	require	VBZ
cord-001835-0s7ok4uw	2978	29	going	go	VBG
cord-001835-0s7ok4uw	2978	30	beyond	beyond	IN
cord-001835-0s7ok4uw	2978	31	the	the	DT
cord-001835-0s7ok4uw	2978	32	static	static	JJ
cord-001835-0s7ok4uw	2978	33	picture	picture	NN
cord-001835-0s7ok4uw	2978	34	produced	produce	VBN
cord-001835-0s7ok4uw	2978	35	by	by	IN
cord-001835-0s7ok4uw	2978	36	X	x	NN
cord-001835-0s7ok4uw	2978	37	-	-	NN
cord-001835-0s7ok4uw	2978	38	ray	ray	NN
cord-001835-0s7ok4uw	2978	39	diffraction	diffraction	NN
cord-001835-0s7ok4uw	2978	40	studies	study	NNS
cord-001835-0s7ok4uw	2978	41	.	.	.
cord-001835-0s7ok4uw	2979	1	Structural	structural	JJ
cord-001835-0s7ok4uw	2979	2	flexibility	flexibility	NN
cord-001835-0s7ok4uw	2979	3	can	can	MD
cord-001835-0s7ok4uw	2979	4	also	also	RB
cord-001835-0s7ok4uw	2979	5	be	be	VB
cord-001835-0s7ok4uw	2979	6	interpreted	interpret	VBN
cord-001835-0s7ok4uw	2979	7	as	as	IN
cord-001835-0s7ok4uw	2979	8	a	a	DT
cord-001835-0s7ok4uw	2979	9	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	2979	10	exchange	exchange	NN
cord-001835-0s7ok4uw	2979	11	between	between	IN
cord-001835-0s7ok4uw	2979	12	different	different	JJ
cord-001835-0s7ok4uw	2979	13	conformational	conformational	JJ
cord-001835-0s7ok4uw	2979	14	states	state	NNS
cord-001835-0s7ok4uw	2979	15	with	with	IN
cord-001835-0s7ok4uw	2979	16	low	low	JJ
cord-001835-0s7ok4uw	2979	17	energy	energy	NN
cord-001835-0s7ok4uw	2979	18	barriers	barrier	NNS
cord-001835-0s7ok4uw	2979	19	at	at	IN
cord-001835-0s7ok4uw	2979	20	room	room	NN
cord-001835-0s7ok4uw	2979	21	temperature	temperature	NN
cord-001835-0s7ok4uw	2979	22	.	.	.
cord-001835-0s7ok4uw	2980	1	Allosterism	allosterism	NN
cord-001835-0s7ok4uw	2980	2	is	be	VBZ
cord-001835-0s7ok4uw	2980	3	a	a	DT
cord-001835-0s7ok4uw	2980	4	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2980	5	to	to	TO
cord-001835-0s7ok4uw	2980	6	regulate	regulate	VB
cord-001835-0s7ok4uw	2980	7	protein	protein	NN
cord-001835-0s7ok4uw	2980	8	function	function	NN
cord-001835-0s7ok4uw	2980	9	associated	associate	VBN
cord-001835-0s7ok4uw	2980	10	with	with	IN
cord-001835-0s7ok4uw	2980	11	the	the	DT
cord-001835-0s7ok4uw	2980	12	plasticity	plasticity	NN
cord-001835-0s7ok4uw	2980	13	exhibited	exhibit	VBN
cord-001835-0s7ok4uw	2980	14	by	by	IN
cord-001835-0s7ok4uw	2980	15	proteins	protein	NNS
cord-001835-0s7ok4uw	2980	16	.	.	.
cord-001835-0s7ok4uw	2981	1	Allosteric	Allosteric	NNP
cord-001835-0s7ok4uw	2981	2	sites	site	NNS
cord-001835-0s7ok4uw	2981	3	can	can	MD
cord-001835-0s7ok4uw	2981	4	be	be	VB
cord-001835-0s7ok4uw	2981	5	considered	consider	VBN
cord-001835-0s7ok4uw	2981	6	transient	transient	JJ
cord-001835-0s7ok4uw	2981	7	cavities	cavity	NNS
cord-001835-0s7ok4uw	2981	8	that	that	WDT
cord-001835-0s7ok4uw	2981	9	can	can	MD
cord-001835-0s7ok4uw	2981	10	be	be	VB
cord-001835-0s7ok4uw	2981	11	occupied	occupy	VBN
cord-001835-0s7ok4uw	2981	12	by	by	IN
cord-001835-0s7ok4uw	2981	13	a	a	DT
cord-001835-0s7ok4uw	2981	14	small	small	JJ
cord-001835-0s7ok4uw	2981	15	molecule	molecule	NN
cord-001835-0s7ok4uw	2981	16	with	with	IN
cord-001835-0s7ok4uw	2981	17	the	the	DT
cord-001835-0s7ok4uw	2981	18	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	2981	19	modulation	modulation	NN
cord-001835-0s7ok4uw	2981	20	of	of	IN
cord-001835-0s7ok4uw	2981	21	the	the	DT
cord-001835-0s7ok4uw	2981	22	protein	protein	NN
cord-001835-0s7ok4uw	2981	23	plasticity	plasticity	NN
cord-001835-0s7ok4uw	2981	24	.	.	.
cord-001835-0s7ok4uw	2982	1	Occupation	occupation	NN
cord-001835-0s7ok4uw	2982	2	of	of	IN
cord-001835-0s7ok4uw	2982	3	these	these	DT
cord-001835-0s7ok4uw	2982	4	sites	site	NNS
cord-001835-0s7ok4uw	2982	5	may	may	MD
cord-001835-0s7ok4uw	2982	6	modify	modify	VB
cord-001835-0s7ok4uw	2982	7	the	the	DT
cord-001835-0s7ok4uw	2982	8	affinity	affinity	NN
cord-001835-0s7ok4uw	2982	9	of	of	IN
cord-001835-0s7ok4uw	2982	10	the	the	DT
cord-001835-0s7ok4uw	2982	11	protein	protein	NN
cord-001835-0s7ok4uw	2982	12	for	for	IN
cord-001835-0s7ok4uw	2982	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2982	14	native	native	JJ
cord-001835-0s7ok4uw	2982	15	substrate	substrate	NN
cord-001835-0s7ok4uw	2982	16	that	that	WDT
cord-001835-0s7ok4uw	2982	17	can	can	MD
cord-001835-0s7ok4uw	2982	18	be	be	VB
cord-001835-0s7ok4uw	2982	19	positive	positive	JJ
cord-001835-0s7ok4uw	2982	20	when	when	WRB
cord-001835-0s7ok4uw	2982	21	the	the	DT
cord-001835-0s7ok4uw	2982	22	affinity	affinity	NN
cord-001835-0s7ok4uw	2982	23	increases	increase	NNS
cord-001835-0s7ok4uw	2982	24	or	or	CC
cord-001835-0s7ok4uw	2982	25	negative	negative	JJ
cord-001835-0s7ok4uw	2982	26	when	when	WRB
cord-001835-0s7ok4uw	2982	27	the	the	DT
cord-001835-0s7ok4uw	2982	28	affinity	affinity	NN
cord-001835-0s7ok4uw	2982	29	decreases	decrease	VBZ
cord-001835-0s7ok4uw	2982	30	.	.	.
cord-001835-0s7ok4uw	2983	1	Allosterism	allosterism	NN
cord-001835-0s7ok4uw	2983	2	can	can	MD
cord-001835-0s7ok4uw	2983	3	be	be	VB
cord-001835-0s7ok4uw	2983	4	used	use	VBN
cord-001835-0s7ok4uw	2983	5	for	for	IN
cord-001835-0s7ok4uw	2983	6	the	the	DT
cord-001835-0s7ok4uw	2983	7	design	design	NN
cord-001835-0s7ok4uw	2983	8	of	of	IN
cord-001835-0s7ok4uw	2983	9	non	non	JJ
cord-001835-0s7ok4uw	2983	10	-	-	JJ
cord-001835-0s7ok4uw	2983	11	competitive	competitive	JJ
cord-001835-0s7ok4uw	2983	12	ligands	ligand	NNS
cord-001835-0s7ok4uw	2983	13	as	as	IN
cord-001835-0s7ok4uw	2983	14	new	new	JJ
cord-001835-0s7ok4uw	2983	15	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	2983	16	agents	agent	NNS
cord-001835-0s7ok4uw	2983	17	.	.	.
cord-001835-0s7ok4uw	2984	1	This	this	DT
cord-001835-0s7ok4uw	2984	2	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2984	3	of	of	IN
cord-001835-0s7ok4uw	2984	4	activity	activity	NN
cord-001835-0s7ok4uw	2984	5	modulation	modulation	NN
cord-001835-0s7ok4uw	2984	6	is	be	VBZ
cord-001835-0s7ok4uw	2984	7	particularly	particularly	RB
cord-001835-0s7ok4uw	2984	8	interesting	interesting	JJ
cord-001835-0s7ok4uw	2984	9	for	for	IN
cord-001835-0s7ok4uw	2984	10	those	those	DT
cord-001835-0s7ok4uw	2984	11	targets	target	NNS
cord-001835-0s7ok4uw	2984	12	that	that	WDT
cord-001835-0s7ok4uw	2984	13	use	use	VBP
cord-001835-0s7ok4uw	2984	14	a	a	DT
cord-001835-0s7ok4uw	2984	15	common	common	JJ
cord-001835-0s7ok4uw	2984	16	substrate	substrate	NN
cord-001835-0s7ok4uw	2984	17	for	for	IN
cord-001835-0s7ok4uw	2984	18	activation	activation	NN
cord-001835-0s7ok4uw	2984	19	,	,	,
cord-001835-0s7ok4uw	2984	20	like	like	UH
cord-001835-0s7ok4uw	2984	21	in	in	IN
cord-001835-0s7ok4uw	2984	22	the	the	DT
cord-001835-0s7ok4uw	2984	23	case	case	NN
cord-001835-0s7ok4uw	2984	24	of	of	IN
cord-001835-0s7ok4uw	2984	25	kinases	kinase	NNS
cord-001835-0s7ok4uw	2984	26	to	to	TO
cord-001835-0s7ok4uw	2984	27	search	search	VB
cord-001835-0s7ok4uw	2984	28	for	for	IN
cord-001835-0s7ok4uw	2984	29	selective	selective	JJ
cord-001835-0s7ok4uw	2984	30	compounds	compound	NNS
cord-001835-0s7ok4uw	2984	31	.	.	.
cord-001835-0s7ok4uw	2985	1	Proteins	protein	NNS
cord-001835-0s7ok4uw	2985	2	can	can	MD
cord-001835-0s7ok4uw	2985	3	be	be	VB
cord-001835-0s7ok4uw	2985	4	viewed	view	VBN
cord-001835-0s7ok4uw	2985	5	in	in	IN
cord-001835-0s7ok4uw	2985	6	solution	solution	NN
cord-001835-0s7ok4uw	2985	7	as	as	IN
cord-001835-0s7ok4uw	2985	8	an	an	DT
cord-001835-0s7ok4uw	2985	9	ensemble	ensemble	NN
cord-001835-0s7ok4uw	2985	10	of	of	IN
cord-001835-0s7ok4uw	2985	11	diverse	diverse	JJ
cord-001835-0s7ok4uw	2985	12	energy	energy	NN
cord-001835-0s7ok4uw	2985	13	accessible	accessible	JJ
cord-001835-0s7ok4uw	2985	14	conformations	conformation	NNS
cord-001835-0s7ok4uw	2985	15	.	.	.
cord-001835-0s7ok4uw	2986	1	Binding	bind	VBG
cord-001835-0s7ok4uw	2986	2	of	of	IN
cord-001835-0s7ok4uw	2986	3	an	an	DT
cord-001835-0s7ok4uw	2986	4	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2986	5	ligand	ligand	NN
cord-001835-0s7ok4uw	2986	6	produces	produce	VBZ
cord-001835-0s7ok4uw	2986	7	a	a	DT
cord-001835-0s7ok4uw	2986	8	redistribution	redistribution	NN
cord-001835-0s7ok4uw	2986	9	of	of	IN
cord-001835-0s7ok4uw	2986	10	the	the	DT
cord-001835-0s7ok4uw	2986	11	population	population	NN
cord-001835-0s7ok4uw	2986	12	of	of	IN
cord-001835-0s7ok4uw	2986	13	the	the	DT
cord-001835-0s7ok4uw	2986	14	diverse	diverse	JJ
cord-001835-0s7ok4uw	2986	15	conformational	conformational	JJ
cord-001835-0s7ok4uw	2986	16	states	state	NNS
cord-001835-0s7ok4uw	2986	17	,	,	,
cord-001835-0s7ok4uw	2986	18	which	which	WDT
cord-001835-0s7ok4uw	2986	19	at	at	IN
cord-001835-0s7ok4uw	2986	20	the	the	DT
cord-001835-0s7ok4uw	2986	21	end	end	NN
cord-001835-0s7ok4uw	2986	22	modulate	modulate	VBP
cord-001835-0s7ok4uw	2986	23	the	the	DT
cord-001835-0s7ok4uw	2986	24	affinity	affinity	NN
cord-001835-0s7ok4uw	2986	25	of	of	IN
cord-001835-0s7ok4uw	2986	26	the	the	DT
cord-001835-0s7ok4uw	2986	27	native	native	JJ
cord-001835-0s7ok4uw	2986	28	substrate	substrate	NN
cord-001835-0s7ok4uw	2986	29	.	.	.
cord-001835-0s7ok4uw	2987	1	Allosteric	Allosteric	NNP
cord-001835-0s7ok4uw	2987	2	sites	site	NNS
cord-001835-0s7ok4uw	2987	3	can	can	MD
cord-001835-0s7ok4uw	2987	4	be	be	VB
cord-001835-0s7ok4uw	2987	5	characterized	characterize	VBN
cord-001835-0s7ok4uw	2987	6	using	use	VBG
cord-001835-0s7ok4uw	2987	7	computational	computational	JJ
cord-001835-0s7ok4uw	2987	8	methods	method	NNS
cord-001835-0s7ok4uw	2987	9	by	by	IN
cord-001835-0s7ok4uw	2987	10	ensemble	ensemble	JJ
cord-001835-0s7ok4uw	2987	11	docking	docking	NN
cord-001835-0s7ok4uw	2987	12	.	.	.
cord-001835-0s7ok4uw	2988	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	2988	2	consist	consist	VBP
cord-001835-0s7ok4uw	2988	3	of	of	IN
cord-001835-0s7ok4uw	2988	4	characterize	characterize	VB
cord-001835-0s7ok4uw	2988	5	a	a	DT
cord-001835-0s7ok4uw	2988	6	set	set	NN
cord-001835-0s7ok4uw	2988	7	of	of	IN
cord-001835-0s7ok4uw	2988	8	structures	structure	NNS
cord-001835-0s7ok4uw	2988	9	that	that	WDT
cord-001835-0s7ok4uw	2988	10	represent	represent	VBP
cord-001835-0s7ok4uw	2988	11	the	the	DT
cord-001835-0s7ok4uw	2988	12	accessible	accessible	JJ
cord-001835-0s7ok4uw	2988	13	conformations	conformation	NNS
cord-001835-0s7ok4uw	2988	14	of	of	IN
cord-001835-0s7ok4uw	2988	15	a	a	DT
cord-001835-0s7ok4uw	2988	16	protein	protein	NN
cord-001835-0s7ok4uw	2988	17	that	that	WDT
cord-001835-0s7ok4uw	2988	18	can	can	MD
cord-001835-0s7ok4uw	2988	19	then	then	RB
cord-001835-0s7ok4uw	2988	20	be	be	VB
cord-001835-0s7ok4uw	2988	21	used	use	VBN
cord-001835-0s7ok4uw	2988	22	to	to	TO
cord-001835-0s7ok4uw	2988	23	perform	perform	VB
cord-001835-0s7ok4uw	2988	24	virtual	virtual	JJ
cord-001835-0s7ok4uw	2988	25	screening	screening	NN
cord-001835-0s7ok4uw	2988	26	.	.	.
cord-001835-0s7ok4uw	2989	1	In	in	IN
cord-001835-0s7ok4uw	2989	2	the	the	DT
cord-001835-0s7ok4uw	2989	3	present	present	JJ
cord-001835-0s7ok4uw	2989	4	work	work	NN
cord-001835-0s7ok4uw	2989	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	2989	6	have	have	VBP
cord-001835-0s7ok4uw	2989	7	studied	study	VBN
cord-001835-0s7ok4uw	2989	8	prospective	prospective	JJ
cord-001835-0s7ok4uw	2989	9	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	2989	10	sites	site	NNS
cord-001835-0s7ok4uw	2989	11	of	of	IN
cord-001835-0s7ok4uw	2989	12	p38	p38	JJ
cord-001835-0s7ok4uw	2989	13	using	use	VBG
cord-001835-0s7ok4uw	2989	14	computational	computational	JJ
cord-001835-0s7ok4uw	2989	15	methods	method	NNS
cord-001835-0s7ok4uw	2989	16	.	.	.
cord-001835-0s7ok4uw	2990	1	The	the	DT
cord-001835-0s7ok4uw	2990	2	protein	protein	NN
cord-001835-0s7ok4uw	2990	3	is	be	VBZ
cord-001835-0s7ok4uw	2990	4	a	a	DT
cord-001835-0s7ok4uw	2990	5	member	member	NN
cord-001835-0s7ok4uw	2990	6	of	of	IN
cord-001835-0s7ok4uw	2990	7	the	the	DT
cord-001835-0s7ok4uw	2990	8	mitogen	mitogen	NN
cord-001835-0s7ok4uw	2990	9	-	-	HYPH
cord-001835-0s7ok4uw	2990	10	activated	activate	VBN
cord-001835-0s7ok4uw	2990	11	protein	protein	NN
cord-001835-0s7ok4uw	2990	12	kinases	kinase	NNS
cord-001835-0s7ok4uw	2990	13	(	(	-LRB-
cord-001835-0s7ok4uw	2990	14	MAPKs	MAPKs	NNP
cord-001835-0s7ok4uw	2990	15	)	)	-RRB-
cord-001835-0s7ok4uw	2990	16	,	,	,
cord-001835-0s7ok4uw	2990	17	a	a	DT
cord-001835-0s7ok4uw	2990	18	highly	highly	RB
cord-001835-0s7ok4uw	2990	19	regulated	regulated	JJ
cord-001835-0s7ok4uw	2990	20	group	group	NN
cord-001835-0s7ok4uw	2990	21	of	of	IN
cord-001835-0s7ok4uw	2990	22	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	2990	23	that	that	WDT
cord-001835-0s7ok4uw	2990	24	control	control	VBP
cord-001835-0s7ok4uw	2990	25	a	a	DT
cord-001835-0s7ok4uw	2990	26	variety	variety	NN
cord-001835-0s7ok4uw	2990	27	of	of	IN
cord-001835-0s7ok4uw	2990	28	physiological	physiological	JJ
cord-001835-0s7ok4uw	2990	29	processes	process	NNS
cord-001835-0s7ok4uw	2990	30	,	,	,
cord-001835-0s7ok4uw	2990	31	including	include	VBG
cord-001835-0s7ok4uw	2990	32	mitosis	mitosis	NN
cord-001835-0s7ok4uw	2990	33	,	,	,
cord-001835-0s7ok4uw	2990	34	gene	gene	NN
cord-001835-0s7ok4uw	2990	35	expression	expression	NN
cord-001835-0s7ok4uw	2990	36	,	,	,
cord-001835-0s7ok4uw	2990	37	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	2990	38	and	and	CC
cord-001835-0s7ok4uw	2990	39	metabolism	metabolism	NN
cord-001835-0s7ok4uw	2990	40	movement	movement	NN
cord-001835-0s7ok4uw	2990	41	among	among	IN
cord-001835-0s7ok4uw	2990	42	others	other	NNS
cord-001835-0s7ok4uw	2990	43	.	.	.
cord-001835-0s7ok4uw	2991	1	The	the	DT
cord-001835-0s7ok4uw	2991	2	conformational	conformational	JJ
cord-001835-0s7ok4uw	2991	3	profile	profile	NN
cord-001835-0s7ok4uw	2991	4	of	of	IN
cord-001835-0s7ok4uw	2991	5	p38	p38	NNP
cord-001835-0s7ok4uw	2991	6	was	be	VBD
cord-001835-0s7ok4uw	2991	7	assessed	assess	VBN
cord-001835-0s7ok4uw	2991	8	using	use	VBG
cord-001835-0s7ok4uw	2991	9	a	a	DT
cord-001835-0s7ok4uw	2991	10	4	4	CD
cord-001835-0s7ok4uw	2991	11	us	us	NNP
cord-001835-0s7ok4uw	2991	12	trajectory	trajectory	NN
cord-001835-0s7ok4uw	2991	13	of	of	IN
cord-001835-0s7ok4uw	2991	14	accelerated	accelerated	JJ
cord-001835-0s7ok4uw	2991	15	molecular	molecular	JJ
cord-001835-0s7ok4uw	2991	16	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	2991	17	as	as	IN
cord-001835-0s7ok4uw	2991	18	sampling	sampling	NN
cord-001835-0s7ok4uw	2991	19	technique	technique	NN
cord-001835-0s7ok4uw	2991	20	in	in	IN
cord-001835-0s7ok4uw	2991	21	explicit	explicit	JJ
cord-001835-0s7ok4uw	2991	22	solvent	solvent	NN
cord-001835-0s7ok4uw	2991	23	.	.	.
cord-001835-0s7ok4uw	2992	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	2992	2	used	use	VBD
cord-001835-0s7ok4uw	2992	3	as	as	IN
cord-001835-0s7ok4uw	2992	4	starting	start	VBG
cord-001835-0s7ok4uw	2992	5	structure	structure	NN
cord-001835-0s7ok4uw	2992	6	the	the	DT
cord-001835-0s7ok4uw	2992	7	apoform	apoform	NN
cord-001835-0s7ok4uw	2992	8	of	of	IN
cord-001835-0s7ok4uw	2992	9	p38	p38	CD
cord-001835-0s7ok4uw	2992	10	in	in	IN
cord-001835-0s7ok4uw	2992	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	2992	12	inactive	inactive	JJ
cord-001835-0s7ok4uw	2992	13	conformation	conformation	NN
cord-001835-0s7ok4uw	2992	14	(	(	-LRB-
cord-001835-0s7ok4uw	2992	15	entry	entry	NN
cord-001835-0s7ok4uw	2992	16	1P38	1p38	CD
cord-001835-0s7ok4uw	2992	17	)	)	-RRB-
cord-001835-0s7ok4uw	2992	18	.	.	.
cord-001835-0s7ok4uw	2993	1	The	the	DT
cord-001835-0s7ok4uw	2993	2	conformational	conformational	JJ
cord-001835-0s7ok4uw	2993	3	features	feature	NNS
cord-001835-0s7ok4uw	2993	4	of	of	IN
cord-001835-0s7ok4uw	2993	5	the	the	DT
cord-001835-0s7ok4uw	2993	6	protein	protein	NN
cord-001835-0s7ok4uw	2993	7	were	be	VBD
cord-001835-0s7ok4uw	2993	8	assessed	assess	VBN
cord-001835-0s7ok4uw	2993	9	through	through	IN
cord-001835-0s7ok4uw	2993	10	the	the	DT
cord-001835-0s7ok4uw	2993	11	analysis	analysis	NN
cord-001835-0s7ok4uw	2993	12	of	of	IN
cord-001835-0s7ok4uw	2993	13	the	the	DT
cord-001835-0s7ok4uw	2993	14	variance	variance	NN
cord-001835-0s7ok4uw	2993	15	of	of	IN
cord-001835-0s7ok4uw	2993	16	the	the	DT
cord-001835-0s7ok4uw	2993	17	most	most	RBS
cord-001835-0s7ok4uw	2993	18	flexible	flexible	JJ
cord-001835-0s7ok4uw	2993	19	regions	region	NNS
cord-001835-0s7ok4uw	2993	20	of	of	IN
cord-001835-0s7ok4uw	2993	21	the	the	DT
cord-001835-0s7ok4uw	2993	22	protein	protein	NN
cord-001835-0s7ok4uw	2993	23	using	use	VBG
cord-001835-0s7ok4uw	2993	24	principal	principal	JJ
cord-001835-0s7ok4uw	2993	25	component	component	NN
cord-001835-0s7ok4uw	2993	26	analysis	analysis	NN
cord-001835-0s7ok4uw	2993	27	.	.	.
cord-001835-0s7ok4uw	2994	1	The	the	DT
cord-001835-0s7ok4uw	2994	2	snapshots	snapshot	NNS
cord-001835-0s7ok4uw	2994	3	of	of	IN
cord-001835-0s7ok4uw	2994	4	the	the	DT
cord-001835-0s7ok4uw	2994	5	trajectory	trajectory	NN
cord-001835-0s7ok4uw	2994	6	were	be	VBD
cord-001835-0s7ok4uw	2994	7	projected	project	VBN
cord-001835-0s7ok4uw	2994	8	onto	onto	IN
cord-001835-0s7ok4uw	2994	9	the	the	DT
cord-001835-0s7ok4uw	2994	10	two	two	CD
cord-001835-0s7ok4uw	2994	11	principal	principal	JJ
cord-001835-0s7ok4uw	2994	12	components	component	NNS
cord-001835-0s7ok4uw	2994	13	.	.	.
cord-001835-0s7ok4uw	2995	1	Subsequent	subsequent	JJ
cord-001835-0s7ok4uw	2995	2	cluster	cluster	NN
cord-001835-0s7ok4uw	2995	3	analysis	analysis	NN
cord-001835-0s7ok4uw	2995	4	permitted	permit	VBD
cord-001835-0s7ok4uw	2995	5	us	-PRON-	PRP
cord-001835-0s7ok4uw	2995	6	to	to	TO
cord-001835-0s7ok4uw	2995	7	select	select	VB
cord-001835-0s7ok4uw	2995	8	a	a	DT
cord-001835-0s7ok4uw	2995	9	few	few	JJ
cord-001835-0s7ok4uw	2995	10	structures	structure	NNS
cord-001835-0s7ok4uw	2995	11	for	for	IN
cord-001835-0s7ok4uw	2995	12	further	further	JJ
cord-001835-0s7ok4uw	2995	13	studies	study	NNS
cord-001835-0s7ok4uw	2995	14	.	.	.
cord-001835-0s7ok4uw	2996	1	Specifically	specifically	RB
cord-001835-0s7ok4uw	2996	2	,	,	,
cord-001835-0s7ok4uw	2996	3	prospective	prospective	JJ
cord-001835-0s7ok4uw	2996	4	biding	biding	NN
cord-001835-0s7ok4uw	2996	5	sites	site	NNS
cord-001835-0s7ok4uw	2996	6	were	be	VBD
cord-001835-0s7ok4uw	2996	7	identified	identify	VBN
cord-001835-0s7ok4uw	2996	8	using	use	VBG
cord-001835-0s7ok4uw	2996	9	a	a	DT
cord-001835-0s7ok4uw	2996	10	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	2996	11	probe	probe	NN
cord-001835-0s7ok4uw	2996	12	as	as	IN
cord-001835-0s7ok4uw	2996	13	implemented	implement	VBN
cord-001835-0s7ok4uw	2996	14	in	in	IN
cord-001835-0s7ok4uw	2996	15	the	the	DT
cord-001835-0s7ok4uw	2996	16	SiteMap	SiteMap	NNP
cord-001835-0s7ok4uw	2996	17	program	program	NN
cord-001835-0s7ok4uw	2996	18	.	.	.
cord-001835-0s7ok4uw	2997	1	The	the	DT
cord-001835-0s7ok4uw	2997	2	results	result	NNS
cord-001835-0s7ok4uw	2997	3	show	show	VBP
cord-001835-0s7ok4uw	2997	4	previously	previously	RB
cord-001835-0s7ok4uw	2997	5	described	describe	VBD
cord-001835-0s7ok4uw	2997	6	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	2997	7	sites	site	NNS
cord-001835-0s7ok4uw	2997	8	and	and	CC
cord-001835-0s7ok4uw	2997	9	some	some	DT
cord-001835-0s7ok4uw	2997	10	new	new	JJ
cord-001835-0s7ok4uw	2997	11	prospective	prospective	JJ
cord-001835-0s7ok4uw	2997	12	ones	one	NNS
cord-001835-0s7ok4uw	2997	13	.	.	.
cord-001835-0s7ok4uw	2998	1	Hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	2998	2	/	/	SYM
cord-001835-0s7ok4uw	2998	3	deuterium	deuterium	NN
cord-001835-0s7ok4uw	2998	4	exchange	exchange	NN
cord-001835-0s7ok4uw	2998	5	-	-	HYPH
cord-001835-0s7ok4uw	2998	6	mass	mass	NN
cord-001835-0s7ok4uw	2998	7	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	2998	8	provides	provide	VBZ
cord-001835-0s7ok4uw	2998	9	clues	clue	NNS
cord-001835-0s7ok4uw	2998	10	on	on	IN
cord-001835-0s7ok4uw	2998	11	the	the	DT
cord-001835-0s7ok4uw	2998	12	mechanism	mechanism	NN
cord-001835-0s7ok4uw	2998	13	of	of	IN
cord-001835-0s7ok4uw	2998	14	action	action	NN
cord-001835-0s7ok4uw	2998	15	of	of	IN
cord-001835-0s7ok4uw	2998	16	Min	Min	NNP
cord-001835-0s7ok4uw	2998	17	E	E	NNP
cord-001835-0s7ok4uw	2998	18	Maria	Maria	NNP
cord-001835-0s7ok4uw	2998	19	T.	T.	NNP
cord-001835-0s7ok4uw	2998	20	Villar	Villar	NNP
cord-001835-0s7ok4uw	2998	21	1	1	CD
cord-001835-0s7ok4uw	2998	22	,	,	,
cord-001835-0s7ok4uw	2998	23	Kyung	Kyung	NNP
cord-001835-0s7ok4uw	2998	24	-	-	HYPH
cord-001835-0s7ok4uw	2998	25	Tae	Tae	NNP
cord-001835-0s7ok4uw	2998	26	Park	Park	NNP
cord-001835-0s7ok4uw	2998	27	2	2	CD
cord-001835-0s7ok4uw	2998	28	,	,	,
cord-001835-0s7ok4uw	2998	29	Joe	Joe	NNP
cord-001835-0s7ok4uw	2998	30	Lutkenhaus	Lutkenhaus	NNP
cord-001835-0s7ok4uw	2998	31	2	2	CD
cord-001835-0s7ok4uw	2998	32	,	,	,
cord-001835-0s7ok4uw	2998	33	Antonio	Antonio	NNP
cord-001835-0s7ok4uw	2998	34	Artigues	Artigues	NNP
cord-001835-0s7ok4uw	2998	35	1	1	CD
cord-001835-0s7ok4uw	2998	36	1	1	CD
cord-001835-0s7ok4uw	2998	37	Cell	Cell	NNP
cord-001835-0s7ok4uw	2998	38	division	division	NN
cord-001835-0s7ok4uw	2998	39	in	in	IN
cord-001835-0s7ok4uw	2998	40	most	most	JJS
cord-001835-0s7ok4uw	2998	41	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	2998	42	is	be	VBZ
cord-001835-0s7ok4uw	2998	43	initiated	initiate	VBN
cord-001835-0s7ok4uw	2998	44	by	by	IN
cord-001835-0s7ok4uw	2998	45	the	the	DT
cord-001835-0s7ok4uw	2998	46	formation	formation	NN
cord-001835-0s7ok4uw	2998	47	of	of	IN
cord-001835-0s7ok4uw	2998	48	the	the	DT
cord-001835-0s7ok4uw	2998	49	Z	z	NN
cord-001835-0s7ok4uw	2998	50	ring	ring	NN
cord-001835-0s7ok4uw	2998	51	,	,	,
cord-001835-0s7ok4uw	2998	52	an	an	DT
cord-001835-0s7ok4uw	2998	53	essential	essential	JJ
cord-001835-0s7ok4uw	2998	54	cytoskeletal	cytoskeletal	JJ
cord-001835-0s7ok4uw	2998	55	element	element	NN
cord-001835-0s7ok4uw	2998	56	that	that	WDT
cord-001835-0s7ok4uw	2998	57	serves	serve	VBZ
cord-001835-0s7ok4uw	2998	58	as	as	IN
cord-001835-0s7ok4uw	2998	59	a	a	DT
cord-001835-0s7ok4uw	2998	60	scaffold	scaffold	NN
cord-001835-0s7ok4uw	2998	61	for	for	IN
cord-001835-0s7ok4uw	2998	62	the	the	DT
cord-001835-0s7ok4uw	2998	63	cytokinesis	cytokinesis	NN
cord-001835-0s7ok4uw	2998	64	machinery	machinery	NN
cord-001835-0s7ok4uw	2998	65	,	,	,
cord-001835-0s7ok4uw	2998	66	at	at	IN
cord-001835-0s7ok4uw	2998	67	the	the	DT
cord-001835-0s7ok4uw	2998	68	mid	mid	JJ
cord-001835-0s7ok4uw	2998	69	body	body	NN
cord-001835-0s7ok4uw	2998	70	of	of	IN
cord-001835-0s7ok4uw	2998	71	the	the	DT
cord-001835-0s7ok4uw	2998	72	cell	cell	NN
cord-001835-0s7ok4uw	2998	73	.	.	.
cord-001835-0s7ok4uw	2999	1	In	in	IN
cord-001835-0s7ok4uw	2999	2	E	e	NN
cord-001835-0s7ok4uw	2999	3	coli	coli	VBZ
cord-001835-0s7ok4uw	2999	4	the	the	DT
cord-001835-0s7ok4uw	2999	5	spatial	spatial	JJ
cord-001835-0s7ok4uw	2999	6	location	location	NN
cord-001835-0s7ok4uw	2999	7	of	of	IN
cord-001835-0s7ok4uw	2999	8	the	the	DT
cord-001835-0s7ok4uw	2999	9	Z	z	NN
cord-001835-0s7ok4uw	2999	10	ring	ring	NN
cord-001835-0s7ok4uw	2999	11	is	be	VBZ
cord-001835-0s7ok4uw	2999	12	regulated	regulate	VBN
cord-001835-0s7ok4uw	2999	13	by	by	IN
cord-001835-0s7ok4uw	2999	14	the	the	DT
cord-001835-0s7ok4uw	2999	15	Min	Min	NNP
cord-001835-0s7ok4uw	2999	16	protein	protein	NN
cord-001835-0s7ok4uw	2999	17	system	system	NN
cord-001835-0s7ok4uw	2999	18	,	,	,
cord-001835-0s7ok4uw	2999	19	comprised	comprise	VBN
cord-001835-0s7ok4uw	2999	20	by	by	IN
cord-001835-0s7ok4uw	2999	21	three	three	CD
cord-001835-0s7ok4uw	2999	22	major	major	JJ
cord-001835-0s7ok4uw	2999	23	proteins	protein	NNS
cord-001835-0s7ok4uw	2999	24	:	:	:
cord-001835-0s7ok4uw	2999	25	MinC	MinC	NNP
cord-001835-0s7ok4uw	2999	26	,	,	,
cord-001835-0s7ok4uw	2999	27	MinD	MinD	NNP
cord-001835-0s7ok4uw	2999	28	and	and	CC
cord-001835-0s7ok4uw	2999	29	MinE.	MinE.	NNP
cord-001835-0s7ok4uw	3000	1	The	the	DT
cord-001835-0s7ok4uw	3000	2	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	3000	3	interaction	interaction	NN
cord-001835-0s7ok4uw	3000	4	between	between	IN
cord-001835-0s7ok4uw	3000	5	these	these	DT
cord-001835-0s7ok4uw	3000	6	proteins	protein	NNS
cord-001835-0s7ok4uw	3000	7	results	result	NNS
cord-001835-0s7ok4uw	3000	8	in	in	IN
cord-001835-0s7ok4uw	3000	9	the	the	DT
cord-001835-0s7ok4uw	3000	10	formation	formation	NN
cord-001835-0s7ok4uw	3000	11	of	of	IN
cord-001835-0s7ok4uw	3000	12	an	an	DT
cord-001835-0s7ok4uw	3000	13	oscillating	oscillate	VBG
cord-001835-0s7ok4uw	3000	14	protein	protein	NN
cord-001835-0s7ok4uw	3000	15	gradient	gradient	NN
cord-001835-0s7ok4uw	3000	16	between	between	IN
cord-001835-0s7ok4uw	3000	17	the	the	DT
cord-001835-0s7ok4uw	3000	18	poles	pole	NNS
cord-001835-0s7ok4uw	3000	19	of	of	IN
cord-001835-0s7ok4uw	3000	20	the	the	DT
cord-001835-0s7ok4uw	3000	21	cell	cell	NN
cord-001835-0s7ok4uw	3000	22	.	.	.
cord-001835-0s7ok4uw	3001	1	This	this	DT
cord-001835-0s7ok4uw	3001	2	oscillation	oscillation	NN
cord-001835-0s7ok4uw	3001	3	determines	determine	VBZ
cord-001835-0s7ok4uw	3001	4	the	the	DT
cord-001835-0s7ok4uw	3001	5	position	position	NN
cord-001835-0s7ok4uw	3001	6	of	of	IN
cord-001835-0s7ok4uw	3001	7	the	the	DT
cord-001835-0s7ok4uw	3001	8	formation	formation	NN
cord-001835-0s7ok4uw	3001	9	of	of	IN
cord-001835-0s7ok4uw	3001	10	the	the	DT
cord-001835-0s7ok4uw	3001	11	Z	z	NN
cord-001835-0s7ok4uw	3001	12	ring	ring	NN
cord-001835-0s7ok4uw	3001	13	.	.	.
cord-001835-0s7ok4uw	3002	1	Many	many	JJ
cord-001835-0s7ok4uw	3002	2	aspects	aspect	NNS
cord-001835-0s7ok4uw	3002	3	of	of	IN
cord-001835-0s7ok4uw	3002	4	this	this	DT
cord-001835-0s7ok4uw	3002	5	simple	simple	JJ
cord-001835-0s7ok4uw	3002	6	mechanism	mechanism	NN
cord-001835-0s7ok4uw	3002	7	are	be	VBP
cord-001835-0s7ok4uw	3002	8	beginning	begin	VBG
cord-001835-0s7ok4uw	3002	9	to	to	TO
cord-001835-0s7ok4uw	3002	10	be	be	VB
cord-001835-0s7ok4uw	3002	11	understood	understand	VBN
cord-001835-0s7ok4uw	3002	12	.	.	.
cord-001835-0s7ok4uw	3003	1	In	in	IN
cord-001835-0s7ok4uw	3003	2	particular	particular	JJ
cord-001835-0s7ok4uw	3003	3	,	,	,
cord-001835-0s7ok4uw	3003	4	the	the	DT
cord-001835-0s7ok4uw	3003	5	conformational	conformational	JJ
cord-001835-0s7ok4uw	3003	6	changes	change	NNS
cord-001835-0s7ok4uw	3003	7	associated	associate	VBN
cord-001835-0s7ok4uw	3003	8	with	with	IN
cord-001835-0s7ok4uw	3003	9	the	the	DT
cord-001835-0s7ok4uw	3003	10	interaction	interaction	NN
cord-001835-0s7ok4uw	3003	11	of	of	IN
cord-001835-0s7ok4uw	3003	12	the	the	DT
cord-001835-0s7ok4uw	3003	13	three	three	CD
cord-001835-0s7ok4uw	3003	14	Min	Min	NNP
cord-001835-0s7ok4uw	3003	15	proteins	protein	NNS
cord-001835-0s7ok4uw	3003	16	between	between	IN
cord-001835-0s7ok4uw	3003	17	them	-PRON-	PRP
cord-001835-0s7ok4uw	3003	18	and	and	CC
cord-001835-0s7ok4uw	3003	19	with	with	IN
cord-001835-0s7ok4uw	3003	20	the	the	DT
cord-001835-0s7ok4uw	3003	21	cell	cell	NN
cord-001835-0s7ok4uw	3003	22	membrane	membrane	NN
cord-001835-0s7ok4uw	3003	23	,	,	,
cord-001835-0s7ok4uw	3003	24	are	be	VBP
cord-001835-0s7ok4uw	3003	25	of	of	IN
cord-001835-0s7ok4uw	3003	26	especial	especial	JJ
cord-001835-0s7ok4uw	3003	27	interest	interest	NN
cord-001835-0s7ok4uw	3003	28	.	.	.
cord-001835-0s7ok4uw	3004	1	Hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3004	2	/	/	SYM
cord-001835-0s7ok4uw	3004	3	deuterium	deuterium	NN
cord-001835-0s7ok4uw	3004	4	exchange	exchange	NN
cord-001835-0s7ok4uw	3004	5	mass	mass	NN
cord-001835-0s7ok4uw	3004	6	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	3004	7	(	(	-LRB-
cord-001835-0s7ok4uw	3004	8	HDX	HDX	NNP
cord-001835-0s7ok4uw	3004	9	MS	MS	NNP
cord-001835-0s7ok4uw	3004	10	)	)	-RRB-
cord-001835-0s7ok4uw	3004	11	is	be	VBZ
cord-001835-0s7ok4uw	3004	12	a	a	DT
cord-001835-0s7ok4uw	3004	13	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	3004	14	technique	technique	NN
cord-001835-0s7ok4uw	3004	15	for	for	IN
cord-001835-0s7ok4uw	3004	16	the	the	DT
cord-001835-0s7ok4uw	3004	17	detection	detection	NN
cord-001835-0s7ok4uw	3004	18	of	of	IN
cord-001835-0s7ok4uw	3004	19	changes	change	NNS
cord-001835-0s7ok4uw	3004	20	in	in	IN
cord-001835-0s7ok4uw	3004	21	protein	protein	NN
cord-001835-0s7ok4uw	3004	22	conformation	conformation	NN
cord-001835-0s7ok4uw	3004	23	and	and	CC
cord-001835-0s7ok4uw	3004	24	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3004	25	.	.	.
cord-001835-0s7ok4uw	3005	1	The	the	DT
cord-001835-0s7ok4uw	3005	2	main	main	JJ
cord-001835-0s7ok4uw	3005	3	advantages	advantage	NNS
cord-001835-0s7ok4uw	3005	4	of	of	IN
cord-001835-0s7ok4uw	3005	5	this	this	DT
cord-001835-0s7ok4uw	3005	6	methodology	methodology	NN
cord-001835-0s7ok4uw	3005	7	are	be	VBP
cord-001835-0s7ok4uw	3005	8	the	the	DT
cord-001835-0s7ok4uw	3005	9	ability	ability	NN
cord-001835-0s7ok4uw	3005	10	to	to	TO
cord-001835-0s7ok4uw	3005	11	study	study	VB
cord-001835-0s7ok4uw	3005	12	native	native	JJ
cord-001835-0s7ok4uw	3005	13	proteins	protein	NNS
cord-001835-0s7ok4uw	3005	14	in	in	IN
cord-001835-0s7ok4uw	3005	15	solution	solution	NN
cord-001835-0s7ok4uw	3005	16	,	,	,
cord-001835-0s7ok4uw	3005	17	the	the	DT
cord-001835-0s7ok4uw	3005	18	requirement	requirement	NN
cord-001835-0s7ok4uw	3005	19	for	for	IN
cord-001835-0s7ok4uw	3005	20	low	low	JJ
cord-001835-0s7ok4uw	3005	21	protein	protein	NN
cord-001835-0s7ok4uw	3005	22	concentrations	concentration	NNS
cord-001835-0s7ok4uw	3005	23	,	,	,
cord-001835-0s7ok4uw	3005	24	the	the	DT
cord-001835-0s7ok4uw	3005	25	potential	potential	NN
cord-001835-0s7ok4uw	3005	26	to	to	TO
cord-001835-0s7ok4uw	3005	27	discriminate	discriminate	VB
cord-001835-0s7ok4uw	3005	28	multiple	multiple	JJ
cord-001835-0s7ok4uw	3005	29	coexisting	coexist	VBG
cord-001835-0s7ok4uw	3005	30	conformations	conformation	NNS
cord-001835-0s7ok4uw	3005	31	,	,	,
cord-001835-0s7ok4uw	3005	32	and	and	CC
cord-001835-0s7ok4uw	3005	33	the	the	DT
cord-001835-0s7ok4uw	3005	34	lack	lack	NN
cord-001835-0s7ok4uw	3005	35	of	of	IN
cord-001835-0s7ok4uw	3005	36	an	an	DT
cord-001835-0s7ok4uw	3005	37	upper	upper	JJ
cord-001835-0s7ok4uw	3005	38	limit	limit	NN
cord-001835-0s7ok4uw	3005	39	to	to	IN
cord-001835-0s7ok4uw	3005	40	the	the	DT
cord-001835-0s7ok4uw	3005	41	size	size	NN
cord-001835-0s7ok4uw	3005	42	of	of	IN
cord-001835-0s7ok4uw	3005	43	protein	protein	NN
cord-001835-0s7ok4uw	3005	44	to	to	TO
cord-001835-0s7ok4uw	3005	45	be	be	VB
cord-001835-0s7ok4uw	3005	46	analyzed	analyze	VBN
cord-001835-0s7ok4uw	3005	47	.	.	.
cord-001835-0s7ok4uw	3006	1	Here	here	RB
cord-001835-0s7ok4uw	3006	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3006	3	use	use	VBP
cord-001835-0s7ok4uw	3006	4	HDX	HDX	NNP
cord-001835-0s7ok4uw	3006	5	MS	MS	NNP
cord-001835-0s7ok4uw	3006	6	to	to	TO
cord-001835-0s7ok4uw	3006	7	analyze	analyze	VB
cord-001835-0s7ok4uw	3006	8	the	the	DT
cord-001835-0s7ok4uw	3006	9	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3006	10	of	of	IN
cord-001835-0s7ok4uw	3006	11	the	the	DT
cord-001835-0s7ok4uw	3006	12	wild	wild	JJ
cord-001835-0s7ok4uw	3006	13	type	type	NN
cord-001835-0s7ok4uw	3006	14	MinE	MinE	NNP
cord-001835-0s7ok4uw	3006	15	and	and	CC
cord-001835-0s7ok4uw	3006	16	of	of	IN
cord-001835-0s7ok4uw	3006	17	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3006	18	inactive	inactive	JJ
cord-001835-0s7ok4uw	3006	19	double	double	JJ
cord-001835-0s7ok4uw	3006	20	mutant	mutant	JJ
cord-001835-0s7ok4uw	3006	21	D45A	d45a	JJ
cord-001835-0s7ok4uw	3006	22	D49A.	d49a.	CD
cord-001835-0s7ok4uw	3007	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3007	2	results	result	NNS
cord-001835-0s7ok4uw	3007	3	show	show	VBP
cord-001835-0s7ok4uw	3007	4	significant	significant	JJ
cord-001835-0s7ok4uw	3007	5	differences	difference	NNS
cord-001835-0s7ok4uw	3007	6	in	in	IN
cord-001835-0s7ok4uw	3007	7	the	the	DT
cord-001835-0s7ok4uw	3007	8	rates	rate	NNS
cord-001835-0s7ok4uw	3007	9	of	of	IN
cord-001835-0s7ok4uw	3007	10	exchange	exchange	NN
cord-001835-0s7ok4uw	3007	11	and	and	CC
cord-001835-0s7ok4uw	3007	12	in	in	IN
cord-001835-0s7ok4uw	3007	13	the	the	DT
cord-001835-0s7ok4uw	3007	14	total	total	JJ
cord-001835-0s7ok4uw	3007	15	amount	amount	NN
cord-001835-0s7ok4uw	3007	16	of	of	IN
cord-001835-0s7ok4uw	3007	17	deuterium	deuterium	NN
cord-001835-0s7ok4uw	3007	18	exchanged	exchange	VBN
cord-001835-0s7ok4uw	3007	19	at	at	IN
cord-001835-0s7ok4uw	3007	20	the	the	DT
cord-001835-0s7ok4uw	3007	21	end	end	NN
cord-001835-0s7ok4uw	3007	22	of	of	IN
cord-001835-0s7ok4uw	3007	23	the	the	DT
cord-001835-0s7ok4uw	3007	24	reaction	reaction	NN
cord-001835-0s7ok4uw	3007	25	between	between	IN
cord-001835-0s7ok4uw	3007	26	these	these	DT
cord-001835-0s7ok4uw	3007	27	two	two	CD
cord-001835-0s7ok4uw	3007	28	forms	form	NNS
cord-001835-0s7ok4uw	3007	29	of	of	IN
cord-001835-0s7ok4uw	3007	30	MinE.	mine.	NN
cord-001835-0s7ok4uw	3008	1	The	the	DT
cord-001835-0s7ok4uw	3008	2	wild	wild	JJ
cord-001835-0s7ok4uw	3008	3	type	type	NN
cord-001835-0s7ok4uw	3008	4	protein	protein	NN
cord-001835-0s7ok4uw	3008	5	exchanges	exchange	NNS
cord-001835-0s7ok4uw	3008	6	most	most	JJS
cord-001835-0s7ok4uw	3008	7	of	of	IN
cord-001835-0s7ok4uw	3008	8	the	the	DT
cord-001835-0s7ok4uw	3008	9	amide	amide	NN
cord-001835-0s7ok4uw	3008	10	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3008	11	during	during	IN
cord-001835-0s7ok4uw	3008	12	the	the	DT
cord-001835-0s7ok4uw	3008	13	first	first	JJ
cord-001835-0s7ok4uw	3008	14	few	few	JJ
cord-001835-0s7ok4uw	3008	15	seconds	second	NNS
cord-001835-0s7ok4uw	3008	16	of	of	IN
cord-001835-0s7ok4uw	3008	17	initiation	initiation	NN
cord-001835-0s7ok4uw	3008	18	of	of	IN
cord-001835-0s7ok4uw	3008	19	the	the	DT
cord-001835-0s7ok4uw	3008	20	exchange	exchange	NN
cord-001835-0s7ok4uw	3008	21	reaction	reaction	NN
cord-001835-0s7ok4uw	3008	22	.	.	.
cord-001835-0s7ok4uw	3009	1	On	on	IN
cord-001835-0s7ok4uw	3009	2	the	the	DT
cord-001835-0s7ok4uw	3009	3	other	other	JJ
cord-001835-0s7ok4uw	3009	4	hand	hand	NN
cord-001835-0s7ok4uw	3009	5	,	,	,
cord-001835-0s7ok4uw	3009	6	the	the	DT
cord-001835-0s7ok4uw	3009	7	mutant	mutant	JJ
cord-001835-0s7ok4uw	3009	8	protein	protein	NN
cord-001835-0s7ok4uw	3009	9	exchanges	exchange	NNS
cord-001835-0s7ok4uw	3009	10	only	only	RB
cord-001835-0s7ok4uw	3009	11	50	50	CD
cord-001835-0s7ok4uw	3009	12	%	%	NN
cord-001835-0s7ok4uw	3009	13	of	of	IN
cord-001835-0s7ok4uw	3009	14	the	the	DT
cord-001835-0s7ok4uw	3009	15	total	total	JJ
cord-001835-0s7ok4uw	3009	16	amide	amide	NN
cord-001835-0s7ok4uw	3009	17	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3009	18	atoms	atom	NNS
cord-001835-0s7ok4uw	3009	19	during	during	IN
cord-001835-0s7ok4uw	3009	20	the	the	DT
cord-001835-0s7ok4uw	3009	21	first	first	JJ
cord-001835-0s7ok4uw	3009	22	seconds	second	NNS
cord-001835-0s7ok4uw	3009	23	of	of	IN
cord-001835-0s7ok4uw	3009	24	initiation	initiation	NN
cord-001835-0s7ok4uw	3009	25	of	of	IN
cord-001835-0s7ok4uw	3009	26	the	the	DT
cord-001835-0s7ok4uw	3009	27	exchange	exchange	NN
cord-001835-0s7ok4uw	3009	28	,	,	,
cord-001835-0s7ok4uw	3009	29	and	and	CC
cord-001835-0s7ok4uw	3009	30	the	the	DT
cord-001835-0s7ok4uw	3009	31	remaining	remain	VBG
cord-001835-0s7ok4uw	3009	32	50	50	CD
cord-001835-0s7ok4uw	3009	33	%	%	NN
cord-001835-0s7ok4uw	3009	34	amide	amide	NN
cord-001835-0s7ok4uw	3009	35	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3009	36	atoms	atom	NNS
cord-001835-0s7ok4uw	3009	37	are	be	VBP
cord-001835-0s7ok4uw	3009	38	exchanged	exchange	VBN
cord-001835-0s7ok4uw	3009	39	more	more	RBR
cord-001835-0s7ok4uw	3009	40	slowly	slowly	RB
cord-001835-0s7ok4uw	3009	41	during	during	IN
cord-001835-0s7ok4uw	3009	42	the	the	DT
cord-001835-0s7ok4uw	3009	43	next	next	JJ
cord-001835-0s7ok4uw	3009	44	few	few	JJ
cord-001835-0s7ok4uw	3009	45	minutes	minute	NNS
cord-001835-0s7ok4uw	3009	46	of	of	IN
cord-001835-0s7ok4uw	3009	47	the	the	DT
cord-001835-0s7ok4uw	3009	48	reaction	reaction	NN
cord-001835-0s7ok4uw	3009	49	.	.	.
cord-001835-0s7ok4uw	3010	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3010	2	data	datum	NNS
cord-001835-0s7ok4uw	3010	3	are	be	VBP
cord-001835-0s7ok4uw	3010	4	consistent	consistent	JJ
cord-001835-0s7ok4uw	3010	5	with	with	IN
cord-001835-0s7ok4uw	3010	6	the	the	DT
cord-001835-0s7ok4uw	3010	7	existence	existence	NN
cord-001835-0s7ok4uw	3010	8	of	of	IN
cord-001835-0s7ok4uw	3010	9	a	a	DT
cord-001835-0s7ok4uw	3010	10	highly	highly	RB
cord-001835-0s7ok4uw	3010	11	flexible	flexible	JJ
cord-001835-0s7ok4uw	3010	12	structure	structure	NN
cord-001835-0s7ok4uw	3010	13	for	for	IN
cord-001835-0s7ok4uw	3010	14	the	the	DT
cord-001835-0s7ok4uw	3010	15	wild	wild	JJ
cord-001835-0s7ok4uw	3010	16	type	type	NN
cord-001835-0s7ok4uw	3010	17	protein	protein	NN
cord-001835-0s7ok4uw	3010	18	and	and	CC
cord-001835-0s7ok4uw	3010	19	the	the	DT
cord-001835-0s7ok4uw	3010	20	coexistence	coexistence	NN
cord-001835-0s7ok4uw	3010	21	of	of	IN
cord-001835-0s7ok4uw	3010	22	at	at	RB
cord-001835-0s7ok4uw	3010	23	least	least	RBS
cord-001835-0s7ok4uw	3010	24	two	two	CD
cord-001835-0s7ok4uw	3010	25	rigid	rigid	JJ
cord-001835-0s7ok4uw	3010	26	conformations	conformation	NNS
cord-001835-0s7ok4uw	3010	27	for	for	IN
cord-001835-0s7ok4uw	3010	28	the	the	DT
cord-001835-0s7ok4uw	3010	29	double	double	JJ
cord-001835-0s7ok4uw	3010	30	mutant	mutant	NN
cord-001835-0s7ok4uw	3010	31	that	that	WDT
cord-001835-0s7ok4uw	3010	32	are	be	VBP
cord-001835-0s7ok4uw	3010	33	undergoing	undergo	VBG
cord-001835-0s7ok4uw	3010	34	a	a	DT
cord-001835-0s7ok4uw	3010	35	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	3010	36	transition	transition	NN
cord-001835-0s7ok4uw	3010	37	.	.	.
cord-001835-0s7ok4uw	3011	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	3011	2	,	,	,
cord-001835-0s7ok4uw	3011	3	the	the	DT
cord-001835-0s7ok4uw	3011	4	central	central	JJ
cord-001835-0s7ok4uw	3011	5	b	b	NN
cord-001835-0s7ok4uw	3011	6	-	-	HYPH
cord-001835-0s7ok4uw	3011	7	sheet	sheet	NN
cord-001835-0s7ok4uw	3011	8	forming	form	VBG
cord-001835-0s7ok4uw	3011	9	the	the	DT
cord-001835-0s7ok4uw	3011	10	interface	interface	NN
cord-001835-0s7ok4uw	3011	11	between	between	IN
cord-001835-0s7ok4uw	3011	12	the	the	DT
cord-001835-0s7ok4uw	3011	13	two	two	CD
cord-001835-0s7ok4uw	3011	14	subunits	subunit	NNS
cord-001835-0s7ok4uw	3011	15	is	be	VBZ
cord-001835-0s7ok4uw	3011	16	protected	protect	VBN
cord-001835-0s7ok4uw	3011	17	against	against	IN
cord-001835-0s7ok4uw	3011	18	exchange	exchange	NN
cord-001835-0s7ok4uw	3011	19	on	on	IN
cord-001835-0s7ok4uw	3011	20	both	both	DT
cord-001835-0s7ok4uw	3011	21	proteins	protein	NNS
cord-001835-0s7ok4uw	3011	22	.	.	.
cord-001835-0s7ok4uw	3012	1	These	these	DT
cord-001835-0s7ok4uw	3012	2	results	result	NNS
cord-001835-0s7ok4uw	3012	3	provide	provide	VBP
cord-001835-0s7ok4uw	3012	4	insights	insight	NNS
cord-001835-0s7ok4uw	3012	5	into	into	IN
cord-001835-0s7ok4uw	3012	6	the	the	DT
cord-001835-0s7ok4uw	3012	7	conformational	conformational	JJ
cord-001835-0s7ok4uw	3012	8	changes	change	NNS
cord-001835-0s7ok4uw	3012	9	that	that	WDT
cord-001835-0s7ok4uw	3012	10	MinE	MinE	NNP
cord-001835-0s7ok4uw	3012	11	undergoes	undergo	VBZ
cord-001835-0s7ok4uw	3012	12	during	during	IN
cord-001835-0s7ok4uw	3012	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3012	14	interaction	interaction	NN
cord-001835-0s7ok4uw	3012	15	with	with	IN
cord-001835-0s7ok4uw	3012	16	MinD.	MinD.	NNP
cord-001835-0s7ok4uw	3013	1	Biased	biased	JJ
cord-001835-0s7ok4uw	3013	2	signalling	signalling	NN
cord-001835-0s7ok4uw	3013	3	and	and	CC
cord-001835-0s7ok4uw	3013	4	heteromization	heteromization	NN
cord-001835-0s7ok4uw	3013	5	of	of	IN
cord-001835-0s7ok4uw	3013	6	the	the	DT
cord-001835-0s7ok4uw	3013	7	Dopamine	Dopamine	NNP
cord-001835-0s7ok4uw	3013	8	D2	d2	NN
cord-001835-0s7ok4uw	3013	9	receptor	receptor	NN
cord-001835-0s7ok4uw	3013	10	in	in	IN
cord-001835-0s7ok4uw	3013	11	Schizophrenia	Schizophrenia	NNP
cord-001835-0s7ok4uw	3013	12	and	and	CC
cord-001835-0s7ok4uw	3013	13	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	3013	14	's	's	POS
cord-001835-0s7ok4uw	3013	15	disease	disease	NN
cord-001835-0s7ok4uw	3013	16	Pablo	Pablo	NNP
cord-001835-0s7ok4uw	3013	17	Herrera	Herrera	NNP
cord-001835-0s7ok4uw	3013	18	Nieto	Nieto	NNP
cord-001835-0s7ok4uw	3013	19	1	1	CD
cord-001835-0s7ok4uw	3013	20	,	,	,
cord-001835-0s7ok4uw	3013	21	James	James	NNP
cord-001835-0s7ok4uw	3013	22	Dalton	Dalton	NNP
cord-001835-0s7ok4uw	3013	23	1	1	CD
cord-001835-0s7ok4uw	3013	24	_	_	NNP
cord-001835-0s7ok4uw	3013	25	,	,	,
cord-001835-0s7ok4uw	3014	1	Jes	Jes	NNP
cord-001835-0s7ok4uw	3014	2	us	us	NNP
cord-001835-0s7ok4uw	3014	3	Giraldo	Giraldo	NNP
cord-001835-0s7ok4uw	3014	4	1	1	CD
cord-001835-0s7ok4uw	3014	5	_	_	NN
cord-001835-0s7ok4uw	3014	6	1	1	CD
cord-001835-0s7ok4uw	3014	7	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	3014	8	Aut	Aut	NNP
cord-001835-0s7ok4uw	3014	9	onoma	onoma	NN
cord-001835-0s7ok4uw	3014	10	de	de	NNP
cord-001835-0s7ok4uw	3014	11	Barcelona	Barcelona	NNP
cord-001835-0s7ok4uw	3014	12	Biased	bias	VBN
cord-001835-0s7ok4uw	3015	1	signalling	signal	VBG
cord-001835-0s7ok4uw	3015	2	and	and	CC
cord-001835-0s7ok4uw	3015	3	heteromization	heteromization	NN
cord-001835-0s7ok4uw	3015	4	of	of	IN
cord-001835-0s7ok4uw	3015	5	the	the	DT
cord-001835-0s7ok4uw	3015	6	Dopamine	Dopamine	NNP
cord-001835-0s7ok4uw	3015	7	D2	d2	NN
cord-001835-0s7ok4uw	3015	8	receptor	receptor	NN
cord-001835-0s7ok4uw	3015	9	in	in	IN
cord-001835-0s7ok4uw	3015	10	Schizophrenia	Schizophrenia	NNP
cord-001835-0s7ok4uw	3015	11	and	and	CC
cord-001835-0s7ok4uw	3015	12	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	3015	13	's	's	POS
cord-001835-0s7ok4uw	3015	14	disease	disease	NN
cord-001835-0s7ok4uw	3015	15	As	as	IN
cord-001835-0s7ok4uw	3015	16	a	a	DT
cord-001835-0s7ok4uw	3015	17	significant	significant	JJ
cord-001835-0s7ok4uw	3015	18	component	component	NN
cord-001835-0s7ok4uw	3015	19	of	of	IN
cord-001835-0s7ok4uw	3015	20	dopamine	dopamine	NN
cord-001835-0s7ok4uw	3015	21	signalling	signal	VBG
cord-001835-0s7ok4uw	3015	22	in	in	IN
cord-001835-0s7ok4uw	3015	23	the	the	DT
cord-001835-0s7ok4uw	3015	24	brain	brain	NN
cord-001835-0s7ok4uw	3015	25	,	,	,
cord-001835-0s7ok4uw	3015	26	the	the	DT
cord-001835-0s7ok4uw	3015	27	dopamine	dopamine	NN
cord-001835-0s7ok4uw	3015	28	D2	D2	NNP
cord-001835-0s7ok4uw	3015	29	receptor	receptor	NN
cord-001835-0s7ok4uw	3015	30	(	(	-LRB-
cord-001835-0s7ok4uw	3015	31	D2R	D2R	NNP
cord-001835-0s7ok4uw	3015	32	)	)	-RRB-
cord-001835-0s7ok4uw	3015	33	,	,	,
cord-001835-0s7ok4uw	3015	34	a	a	DT
cord-001835-0s7ok4uw	3015	35	member	member	NN
cord-001835-0s7ok4uw	3015	36	of	of	IN
cord-001835-0s7ok4uw	3015	37	the	the	DT
cord-001835-0s7ok4uw	3015	38	Class	Class	NNP
cord-001835-0s7ok4uw	3015	39	A	A	NNP
cord-001835-0s7ok4uw	3015	40	GPCR	GPCR	NNP
cord-001835-0s7ok4uw	3015	41	family	family	NN
cord-001835-0s7ok4uw	3015	42	,	,	,
cord-001835-0s7ok4uw	3015	43	is	be	VBZ
cord-001835-0s7ok4uw	3015	44	an	an	DT
cord-001835-0s7ok4uw	3015	45	important	important	JJ
cord-001835-0s7ok4uw	3015	46	target	target	NN
cord-001835-0s7ok4uw	3015	47	in	in	IN
cord-001835-0s7ok4uw	3015	48	the	the	DT
cord-001835-0s7ok4uw	3015	49	treatment	treatment	NN
cord-001835-0s7ok4uw	3015	50	of	of	IN
cord-001835-0s7ok4uw	3015	51	neurological	neurological	JJ
cord-001835-0s7ok4uw	3015	52	conditions	condition	NNS
cord-001835-0s7ok4uw	3015	53	such	such	JJ
cord-001835-0s7ok4uw	3015	54	as	as	IN
cord-001835-0s7ok4uw	3015	55	schizophrenia	schizophrenia	NN
cord-001835-0s7ok4uw	3015	56	and	and	CC
cord-001835-0s7ok4uw	3015	57	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	3015	58	's	's	POS
cord-001835-0s7ok4uw	3015	59	disease	disease	NN
cord-001835-0s7ok4uw	3015	60	.	.	.
cord-001835-0s7ok4uw	3016	1	D2R	D2R	NNP
cord-001835-0s7ok4uw	3016	2	shows	show	VBZ
cord-001835-0s7ok4uw	3016	3	a	a	DT
cord-001835-0s7ok4uw	3016	4	variety	variety	NN
cord-001835-0s7ok4uw	3016	5	of	of	IN
cord-001835-0s7ok4uw	3016	6	signalling	signal	VBG
cord-001835-0s7ok4uw	3016	7	pathways	pathway	NNS
cord-001835-0s7ok4uw	3016	8	through	through	IN
cord-001835-0s7ok4uw	3016	9	G	g	NN
cord-001835-0s7ok4uw	3016	10	proteins	protein	NNS
cord-001835-0s7ok4uw	3016	11	,	,	,
cord-001835-0s7ok4uw	3016	12	including	include	VBG
cord-001835-0s7ok4uw	3016	13	adenylyl	adenylyl	JJ
cord-001835-0s7ok4uw	3016	14	cyclase	cyclase	NN
cord-001835-0s7ok4uw	3016	15	inhibition	inhibition	NN
cord-001835-0s7ok4uw	3016	16	,	,	,
cord-001835-0s7ok4uw	3016	17	Gbgpotentiation	Gbgpotentiation	NNP
cord-001835-0s7ok4uw	3016	18	of	of	IN
cord-001835-0s7ok4uw	3016	19	adenylyl	adenylyl	NN
cord-001835-0s7ok4uw	3016	20	cyclase	cyclase	NN
cord-001835-0s7ok4uw	3016	21	2	2	CD
cord-001835-0s7ok4uw	3016	22	,	,	,
cord-001835-0s7ok4uw	3016	23	and	and	CC
cord-001835-0s7ok4uw	3016	24	ERK	ERK	NNP
cord-001835-0s7ok4uw	3016	25	kinase	kinase	NN
cord-001835-0s7ok4uw	3016	26	activation	activation	NN
cord-001835-0s7ok4uw	3016	27	,	,	,
cord-001835-0s7ok4uw	3016	28	in	in	IN
cord-001835-0s7ok4uw	3016	29	addition	addition	NN
cord-001835-0s7ok4uw	3016	30	to	to	IN
cord-001835-0s7ok4uw	3016	31	b	b	LS
cord-001835-0s7ok4uw	3016	32	-	-	HYPH
cord-001835-0s7ok4uw	3016	33	arrestin	arrestin	NN
cord-001835-0s7ok4uw	3016	34	recruitment	recruitment	NN
cord-001835-0s7ok4uw	3016	35	,	,	,
cord-001835-0s7ok4uw	3016	36	.	.	.
cord-001835-0s7ok4uw	3017	1	These	these	DT
cord-001835-0s7ok4uw	3017	2	pathways	pathway	NNS
cord-001835-0s7ok4uw	3017	3	are	be	VBP
cord-001835-0s7ok4uw	3017	4	differentially	differentially	RB
cord-001835-0s7ok4uw	3017	5	activated	activate	VBN
cord-001835-0s7ok4uw	3017	6	by	by	IN
cord-001835-0s7ok4uw	3017	7	some	some	DT
cord-001835-0s7ok4uw	3017	8	agonists	agonist	NNS
cord-001835-0s7ok4uw	3017	9	and	and	CC
cord-001835-0s7ok4uw	3017	10	it	-PRON-	PRP
cord-001835-0s7ok4uw	3017	11	has	have	VBZ
cord-001835-0s7ok4uw	3017	12	been	be	VBN
cord-001835-0s7ok4uw	3017	13	suggested	suggest	VBN
cord-001835-0s7ok4uw	3017	14	that	that	IN
cord-001835-0s7ok4uw	3017	15	D2R	d2r	NN
cord-001835-0s7ok4uw	3017	16	ligands	ligand	NNS
cord-001835-0s7ok4uw	3017	17	with	with	IN
cord-001835-0s7ok4uw	3017	18	Gai	Gai	NNP
cord-001835-0s7ok4uw	3017	19	/	/	SYM
cord-001835-0s7ok4uw	3017	20	o	o	NN
cord-001835-0s7ok4uw	3017	21	antagonist	antagonist	NN
cord-001835-0s7ok4uw	3017	22	and	and	CC
cord-001835-0s7ok4uw	3018	1	b	b	LS
cord-001835-0s7ok4uw	3018	2	-	-	:
cord-001835-0s7ok4uw	3018	3	arrestin	arrestin	JJ
cord-001835-0s7ok4uw	3018	4	agonist	agonist	NN
cord-001835-0s7ok4uw	3018	5	activity	activity	NN
cord-001835-0s7ok4uw	3018	6	may	may	MD
cord-001835-0s7ok4uw	3018	7	have	have	VB
cord-001835-0s7ok4uw	3018	8	anti	anti	JJ
cord-001835-0s7ok4uw	3018	9	-	-	JJ
cord-001835-0s7ok4uw	3018	10	psychotic	psychotic	JJ
cord-001835-0s7ok4uw	3018	11	behavioural	behavioural	JJ
cord-001835-0s7ok4uw	3018	12	activity	activity	NN
cord-001835-0s7ok4uw	3018	13	with	with	IN
cord-001835-0s7ok4uw	3018	14	reduced	reduce	VBN
cord-001835-0s7ok4uw	3018	15	extra	extra	JJ
cord-001835-0s7ok4uw	3018	16	-	-	JJ
cord-001835-0s7ok4uw	3018	17	pyramidal	pyramidal	JJ
cord-001835-0s7ok4uw	3018	18	side	side	NN
cord-001835-0s7ok4uw	3018	19	effects	effect	NNS
cord-001835-0s7ok4uw	3018	20	.	.	.
cord-001835-0s7ok4uw	3019	1	D2R	D2R	NNP
cord-001835-0s7ok4uw	3019	2	has	have	VBZ
cord-001835-0s7ok4uw	3019	3	also	also	RB
cord-001835-0s7ok4uw	3019	4	been	be	VBN
cord-001835-0s7ok4uw	3019	5	found	find	VBN
cord-001835-0s7ok4uw	3019	6	to	to	TO
cord-001835-0s7ok4uw	3019	7	form	form	VB
cord-001835-0s7ok4uw	3019	8	homodimers	homodimer	NNS
cord-001835-0s7ok4uw	3019	9	or	or	CC
cord-001835-0s7ok4uw	3019	10	higher	high	JJR
cord-001835-0s7ok4uw	3019	11	-	-	HYPH
cord-001835-0s7ok4uw	3019	12	order	order	NN
cord-001835-0s7ok4uw	3019	13	hetero	hetero	NNS
cord-001835-0s7ok4uw	3019	14	-	-	NNS
cord-001835-0s7ok4uw	3019	15	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	3019	16	with	with	IN
cord-001835-0s7ok4uw	3019	17	other	other	JJ
cord-001835-0s7ok4uw	3019	18	GPCRs	gpcr	NNS
cord-001835-0s7ok4uw	3019	19	,	,	,
cord-001835-0s7ok4uw	3019	20	which	which	WDT
cord-001835-0s7ok4uw	3019	21	may	may	MD
cord-001835-0s7ok4uw	3019	22	modulate	modulate	VB
cord-001835-0s7ok4uw	3019	23	D2R	d2r	NN
cord-001835-0s7ok4uw	3019	24	conformation	conformation	NN
cord-001835-0s7ok4uw	3019	25	and	and	CC
cord-001835-0s7ok4uw	3019	26	activity	activity	NN
cord-001835-0s7ok4uw	3019	27	,	,	,
cord-001835-0s7ok4uw	3019	28	thus	thus	RB
cord-001835-0s7ok4uw	3019	29	constituting	constitute	VBG
cord-001835-0s7ok4uw	3019	30	an	an	DT
cord-001835-0s7ok4uw	3019	31	additional	additional	JJ
cord-001835-0s7ok4uw	3019	32	form	form	NN
cord-001835-0s7ok4uw	3019	33	of	of	IN
cord-001835-0s7ok4uw	3019	34	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	3019	35	receptor	receptor	NN
cord-001835-0s7ok4uw	3019	36	regulation	regulation	NN
cord-001835-0s7ok4uw	3019	37	.	.	.
cord-001835-0s7ok4uw	3020	1	Based	base	VBN
cord-001835-0s7ok4uw	3020	2	on	on	IN
cord-001835-0s7ok4uw	3020	3	these	these	DT
cord-001835-0s7ok4uw	3020	4	findings	finding	NNS
cord-001835-0s7ok4uw	3020	5	,	,	,
cord-001835-0s7ok4uw	3020	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	3020	7	have	have	VBP
cord-001835-0s7ok4uw	3020	8	computationally	computationally	RB
cord-001835-0s7ok4uw	3020	9	modelled	model	VBN
cord-001835-0s7ok4uw	3020	10	the	the	DT
cord-001835-0s7ok4uw	3020	11	full	full	JJ
cord-001835-0s7ok4uw	3020	12	-	-	HYPH
cord-001835-0s7ok4uw	3020	13	length	length	NN
cord-001835-0s7ok4uw	3020	14	structure	structure	NN
cord-001835-0s7ok4uw	3020	15	of	of	IN
cord-001835-0s7ok4uw	3020	16	D2R	d2r	NN
cord-001835-0s7ok4uw	3020	17	,	,	,
cord-001835-0s7ok4uw	3020	18	including	include	VBG
cord-001835-0s7ok4uw	3020	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3020	20	long	long	JJ
cord-001835-0s7ok4uw	3020	21	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3020	22	loop	loop	NN
cord-001835-0s7ok4uw	3020	23	3	3	CD
cord-001835-0s7ok4uw	3020	24	(	(	-LRB-
cord-001835-0s7ok4uw	3020	25	ICL3	ICL3	NNP
cord-001835-0s7ok4uw	3020	26	)	)	-RRB-
cord-001835-0s7ok4uw	3020	27	that	that	WDT
cord-001835-0s7ok4uw	3020	28	is	be	VBZ
cord-001835-0s7ok4uw	3020	29	1301	1301	CD
cord-001835-0s7ok4uw	3020	30	residues	residue	NNS
cord-001835-0s7ok4uw	3020	31	in	in	IN
cord-001835-0s7ok4uw	3020	32	length	length	NN
cord-001835-0s7ok4uw	3020	33	and	and	CC
cord-001835-0s7ok4uw	3020	34	absent	absent	JJ
cord-001835-0s7ok4uw	3020	35	in	in	IN
cord-001835-0s7ok4uw	3020	36	all	all	DT
cord-001835-0s7ok4uw	3020	37	homologous	homologous	JJ
cord-001835-0s7ok4uw	3020	38	GPCR	GPCR	NNP
cord-001835-0s7ok4uw	3020	39	crystal	crystal	NN
cord-001835-0s7ok4uw	3020	40	structures	structure	NNS
cord-001835-0s7ok4uw	3020	41	.	.	.
cord-001835-0s7ok4uw	3021	1	Using	use	VBG
cord-001835-0s7ok4uw	3021	2	state	state	NN
cord-001835-0s7ok4uw	3021	3	-	-	HYPH
cord-001835-0s7ok4uw	3021	4	of	of	IN
cord-001835-0s7ok4uw	3021	5	-	-	HYPH
cord-001835-0s7ok4uw	3021	6	the	the	DT
cord-001835-0s7ok4uw	3021	7	-	-	HYPH
cord-001835-0s7ok4uw	3021	8	art	art	NN
cord-001835-0s7ok4uw	3021	9	tools	tool	NNS
cord-001835-0s7ok4uw	3021	10	,	,	,
cord-001835-0s7ok4uw	3021	11	such	such	JJ
cord-001835-0s7ok4uw	3021	12	as	as	IN
cord-001835-0s7ok4uw	3021	13	ROSETTA	ROSETTA	NNP
cord-001835-0s7ok4uw	3021	14	for	for	IN
cord-001835-0s7ok4uw	3021	15	ab	ab	FW
cord-001835-0s7ok4uw	3021	16	initio	initio	NNP
cord-001835-0s7ok4uw	3021	17	protein	protein	NN
cord-001835-0s7ok4uw	3021	18	folding	folding	NN
cord-001835-0s7ok4uw	3021	19	and	and	CC
cord-001835-0s7ok4uw	3021	20	ACEMD	ACEMD	NNP
cord-001835-0s7ok4uw	3021	21	for	for	IN
cord-001835-0s7ok4uw	3021	22	micro	micro	JJ
cord-001835-0s7ok4uw	3021	23	-	-	JJ
cord-001835-0s7ok4uw	3021	24	second1	second1	JJ
cord-001835-0s7ok4uw	3021	25	molecular	molecular	JJ
cord-001835-0s7ok4uw	3021	26	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3021	27	(	(	-LRB-
cord-001835-0s7ok4uw	3021	28	MD	MD	NNP
cord-001835-0s7ok4uw	3021	29	)	)	-RRB-
cord-001835-0s7ok4uw	3021	30	simulations	simulation	NNS
cord-001835-0s7ok4uw	3021	31	we	-PRON-	PRP
cord-001835-0s7ok4uw	3021	32	have	have	VBP
cord-001835-0s7ok4uw	3021	33	successfully	successfully	RB
cord-001835-0s7ok4uw	3021	34	de	de	NNP
cord-001835-0s7ok4uw	3021	35	novo	novo	NNP
cord-001835-0s7ok4uw	3021	36	folded	fold	VBD
cord-001835-0s7ok4uw	3021	37	ICL3	ICL3	NNP
cord-001835-0s7ok4uw	3021	38	,	,	,
cord-001835-0s7ok4uw	3021	39	which	which	WDT
cord-001835-0s7ok4uw	3021	40	primarily	primarily	RB
cord-001835-0s7ok4uw	3021	41	consists	consist	VBZ
cord-001835-0s7ok4uw	3021	42	of	of	IN
cord-001835-0s7ok4uw	3021	43	extensions	extension	NNS
cord-001835-0s7ok4uw	3021	44	to	to	IN
cord-001835-0s7ok4uw	3021	45	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	3021	46	helices	helix	NNS
cord-001835-0s7ok4uw	3021	47	(	(	-LRB-
cord-001835-0s7ok4uw	3021	48	TMH	TMH	NNP
cord-001835-0s7ok4uw	3021	49	)	)	-RRB-
cord-001835-0s7ok4uw	3021	50	5	5	CD
cord-001835-0s7ok4uw	3021	51	and	and	CC
cord-001835-0s7ok4uw	3021	52	6	6	CD
cord-001835-0s7ok4uw	3021	53	and	and	CC
cord-001835-0s7ok4uw	3021	54	an	an	DT
cord-001835-0s7ok4uw	3021	55	intervening	intervene	VBG
cord-001835-0s7ok4uw	3021	56	disordered	disordered	JJ
cord-001835-0s7ok4uw	3021	57	histidine	histidine	NN
cord-001835-0s7ok4uw	3021	58	/	/	SYM
cord-001835-0s7ok4uw	3021	59	proline	proline	JJ
cord-001835-0s7ok4uw	3021	60	-	-	HYPH
cord-001835-0s7ok4uw	3021	61	rich	rich	JJ
cord-001835-0s7ok4uw	3021	62	region	region	NN
cord-001835-0s7ok4uw	3021	63	,	,	,
cord-001835-0s7ok4uw	3021	64	which	which	WDT
cord-001835-0s7ok4uw	3021	65	is	be	VBZ
cord-001835-0s7ok4uw	3021	66	highly	highly	RB
cord-001835-0s7ok4uw	3021	67	flexible	flexible	JJ
cord-001835-0s7ok4uw	3021	68	.	.	.
cord-001835-0s7ok4uw	3022	1	The	the	DT
cord-001835-0s7ok4uw	3022	2	latter	latter	JJ
cord-001835-0s7ok4uw	3022	3	is	be	VBZ
cord-001835-0s7ok4uw	3022	4	observed	observe	VBN
cord-001835-0s7ok4uw	3022	5	to	to	TO
cord-001835-0s7ok4uw	3022	6	interact	interact	VB
cord-001835-0s7ok4uw	3022	7	with	with	IN
cord-001835-0s7ok4uw	3022	8	other	other	JJ
cord-001835-0s7ok4uw	3022	9	receptor	receptor	NN
cord-001835-0s7ok4uw	3022	10	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3022	11	loops	loop	NNS
cord-001835-0s7ok4uw	3022	12	(	(	-LRB-
cord-001835-0s7ok4uw	3022	13	ICL1	ICL1	NNP
cord-001835-0s7ok4uw	3022	14	and	and	CC
cord-001835-0s7ok4uw	3022	15	ICL2	ICL2	NNP
cord-001835-0s7ok4uw	3022	16	)	)	-RRB-
cord-001835-0s7ok4uw	3022	17	and	and	CC
cord-001835-0s7ok4uw	3022	18	appears	appear	VBZ
cord-001835-0s7ok4uw	3022	19	to	to	TO
cord-001835-0s7ok4uw	3022	20	restrict	restrict	VB
cord-001835-0s7ok4uw	3022	21	access	access	NN
cord-001835-0s7ok4uw	3022	22	to	to	IN
cord-001835-0s7ok4uw	3022	23	the	the	DT
cord-001835-0s7ok4uw	3022	24	G	g	NN
cord-001835-0s7ok4uw	3022	25	-	-	HYPH
cord-001835-0s7ok4uw	3022	26	protein	protein	NN
cord-001835-0s7ok4uw	3022	27	binding	binding	NN
cord-001835-0s7ok4uw	3022	28	-	-	HYPH
cord-001835-0s7ok4uw	3022	29	site	site	NN
cord-001835-0s7ok4uw	3022	30	.	.	.
cord-001835-0s7ok4uw	3023	1	In	in	IN
cord-001835-0s7ok4uw	3023	2	addition	addition	NN
cord-001835-0s7ok4uw	3023	3	,	,	,
cord-001835-0s7ok4uw	3023	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3023	5	have	have	VBP
cord-001835-0s7ok4uw	3023	6	docked	dock	VBN
cord-001835-0s7ok4uw	3023	7	a	a	DT
cord-001835-0s7ok4uw	3023	8	structurally	structurally	RB
cord-001835-0s7ok4uw	3023	9	diverse	diverse	JJ
cord-001835-0s7ok4uw	3023	10	collection	collection	NN
cord-001835-0s7ok4uw	3023	11	of	of	IN
cord-001835-0s7ok4uw	3023	12	14	14	CD
cord-001835-0s7ok4uw	3023	13	ligands	ligand	NNS
cord-001835-0s7ok4uw	3023	14	(	(	-LRB-
cord-001835-0s7ok4uw	3023	15	biased	biased	JJ
cord-001835-0s7ok4uw	3023	16	agonists	agonist	NNS
cord-001835-0s7ok4uw	3023	17	,	,	,
cord-001835-0s7ok4uw	3023	18	antagonists	antagonist	NNS
cord-001835-0s7ok4uw	3023	19	and	and	CC
cord-001835-0s7ok4uw	3023	20	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	3023	21	modulators	modulator	NNS
cord-001835-0s7ok4uw	3023	22	)	)	-RRB-
cord-001835-0s7ok4uw	3023	23	into	into	IN
cord-001835-0s7ok4uw	3023	24	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3023	25	D2R	d2r	NN
cord-001835-0s7ok4uw	3023	26	model	model	NN
cord-001835-0s7ok4uw	3023	27	and	and	CC
cord-001835-0s7ok4uw	3023	28	observed	observe	VBD
cord-001835-0s7ok4uw	3023	29	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	3023	30	binding	bind	VBG
cord-001835-0s7ok4uw	3023	31	patterns	pattern	NNS
cord-001835-0s7ok4uw	3023	32	suggestive	suggestive	JJ
cord-001835-0s7ok4uw	3023	33	of	of	IN
cord-001835-0s7ok4uw	3023	34	different	different	JJ
cord-001835-0s7ok4uw	3023	35	biased	biased	JJ
cord-001835-0s7ok4uw	3023	36	signalling	signalling	NN
cord-001835-0s7ok4uw	3023	37	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	3023	38	.	.	.
cord-001835-0s7ok4uw	3024	1	Finally	finally	RB
cord-001835-0s7ok4uw	3024	2	,	,	,
cord-001835-0s7ok4uw	3024	3	through	through	IN
cord-001835-0s7ok4uw	3024	4	protein	protein	NN
cord-001835-0s7ok4uw	3024	5	-	-	HYPH
cord-001835-0s7ok4uw	3024	6	protein	protein	NN
cord-001835-0s7ok4uw	3024	7	docking	docking	NN
cord-001835-0s7ok4uw	3024	8	with	with	IN
cord-001835-0s7ok4uw	3024	9	ROSETTADOCK	ROSETTADOCK	NNP
cord-001835-0s7ok4uw	3024	10	,	,	,
cord-001835-0s7ok4uw	3024	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	3024	12	have	have	VBP
cord-001835-0s7ok4uw	3024	13	generated	generate	VBN
cord-001835-0s7ok4uw	3024	14	a	a	DT
cord-001835-0s7ok4uw	3024	15	complete	complete	JJ
cord-001835-0s7ok4uw	3024	16	heterodimer	heterodimer	NN
cord-001835-0s7ok4uw	3024	17	model	model	NN
cord-001835-0s7ok4uw	3024	18	of	of	IN
cord-001835-0s7ok4uw	3024	19	D2R	d2r	NN
cord-001835-0s7ok4uw	3024	20	with	with	IN
cord-001835-0s7ok4uw	3024	21	the	the	DT
cord-001835-0s7ok4uw	3024	22	Adenosine	Adenosine	NNP
cord-001835-0s7ok4uw	3024	23	A2A	a2a	NN
cord-001835-0s7ok4uw	3024	24	receptor	receptor	NN
cord-001835-0s7ok4uw	3024	25	(	(	-LRB-
cord-001835-0s7ok4uw	3024	26	AA2AR	AA2AR	NNP
cord-001835-0s7ok4uw	3024	27	)	)	-RRB-
cord-001835-0s7ok4uw	3024	28	,	,	,
cord-001835-0s7ok4uw	3024	29	where	where	WRB
cord-001835-0s7ok4uw	3024	30	a	a	DT
cord-001835-0s7ok4uw	3024	31	mutual	mutual	JJ
cord-001835-0s7ok4uw	3024	32	interface	interface	NN
cord-001835-0s7ok4uw	3024	33	is	be	VBZ
cord-001835-0s7ok4uw	3024	34	formed	form	VBN
cord-001835-0s7ok4uw	3024	35	between	between	IN
cord-001835-0s7ok4uw	3024	36	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3024	37	respective	respective	JJ
cord-001835-0s7ok4uw	3024	38	TMHs	tmh	NNS
cord-001835-0s7ok4uw	3024	39	4	4	CD
cord-001835-0s7ok4uw	3024	40	and	and	CC
cord-001835-0s7ok4uw	3024	41	5	5	CD
cord-001835-0s7ok4uw	3024	42	,	,	,
cord-001835-0s7ok4uw	3024	43	as	as	RB
cord-001835-0s7ok4uw	3024	44	well	well	RB
cord-001835-0s7ok4uw	3024	45	as	as	IN
cord-001835-0s7ok4uw	3024	46	an	an	DT
cord-001835-0s7ok4uw	3024	47	association	association	NN
cord-001835-0s7ok4uw	3024	48	between	between	IN
cord-001835-0s7ok4uw	3024	49	the	the	DT
cord-001835-0s7ok4uw	3024	50	C	C	NNP
cord-001835-0s7ok4uw	3024	51	-	-	HYPH
cord-001835-0s7ok4uw	3024	52	terminus	terminus	NN
cord-001835-0s7ok4uw	3024	53	of	of	IN
cord-001835-0s7ok4uw	3024	54	AA2AR	AA2AR	NNP
cord-001835-0s7ok4uw	3024	55	and	and	CC
cord-001835-0s7ok4uw	3024	56	ICL3	ICL3	NNP
cord-001835-0s7ok4uw	3024	57	of	of	IN
cord-001835-0s7ok4uw	3024	58	D2R.	D2R.	NNP
cord-001835-0s7ok4uw	3025	1	This	this	DT
cord-001835-0s7ok4uw	3025	2	may	may	MD
cord-001835-0s7ok4uw	3025	3	be	be	VB
cord-001835-0s7ok4uw	3025	4	a	a	DT
cord-001835-0s7ok4uw	3025	5	particularly	particularly	RB
cord-001835-0s7ok4uw	3025	6	relevant	relevant	JJ
cord-001835-0s7ok4uw	3025	7	biological	biological	JJ
cord-001835-0s7ok4uw	3025	8	complex	complex	NN
cord-001835-0s7ok4uw	3025	9	in	in	IN
cord-001835-0s7ok4uw	3025	10	the	the	DT
cord-001835-0s7ok4uw	3025	11	treatment	treatment	NN
cord-001835-0s7ok4uw	3025	12	of	of	IN
cord-001835-0s7ok4uw	3025	13	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	3025	14	's	's	POS
cord-001835-0s7ok4uw	3025	15	disease	disease	NN
cord-001835-0s7ok4uw	3025	16	where	where	WRB
cord-001835-0s7ok4uw	3025	17	antagonists	antagonist	NNS
cord-001835-0s7ok4uw	3025	18	of	of	IN
cord-001835-0s7ok4uw	3025	19	AA2AR	AA2AR	NNP
cord-001835-0s7ok4uw	3025	20	have	have	VBP
cord-001835-0s7ok4uw	3025	21	been	be	VBN
cord-001835-0s7ok4uw	3025	22	shown	show	VBN
cord-001835-0s7ok4uw	3025	23	to	to	TO
cord-001835-0s7ok4uw	3025	24	ameliorate	ameliorate	VB
cord-001835-0s7ok4uw	3025	25	disease	disease	NN
cord-001835-0s7ok4uw	3025	26	effects	effect	NNS
cord-001835-0s7ok4uw	3025	27	,	,	,
cord-001835-0s7ok4uw	3025	28	potentially	potentially	RB
cord-001835-0s7ok4uw	3025	29	through	through	IN
cord-001835-0s7ok4uw	3025	30	direct	direct	JJ
cord-001835-0s7ok4uw	3025	31	interaction	interaction	NN
cord-001835-0s7ok4uw	3025	32	with	with	IN
cord-001835-0s7ok4uw	3025	33	D2R.	D2R.	NNP
cord-001835-0s7ok4uw	3025	34	Bis	Bis	NNP
cord-001835-0s7ok4uw	3025	35	-	-	HYPH
cord-001835-0s7ok4uw	3025	36	ANS	ANS	NNP
cord-001835-0s7ok4uw	3025	37	as	as	IN
cord-001835-0s7ok4uw	3025	38	a	a	DT
cord-001835-0s7ok4uw	3025	39	tool	tool	NN
cord-001835-0s7ok4uw	3025	40	to	to	TO
cord-001835-0s7ok4uw	3025	41	monitor	monitor	VB
cord-001835-0s7ok4uw	3025	42	conformational	conformational	JJ
cord-001835-0s7ok4uw	3025	43	changes	change	NNS
cord-001835-0s7ok4uw	3025	44	upon	upon	IN
cord-001835-0s7ok4uw	3025	45	assembly	assembly	NN
cord-001835-0s7ok4uw	3025	46	of	of	IN
cord-001835-0s7ok4uw	3025	47	binary	binary	JJ
cord-001835-0s7ok4uw	3025	48	and	and	CC
cord-001835-0s7ok4uw	3025	49	ternary	ternary	JJ
cord-001835-0s7ok4uw	3025	50	complexes	complex	NNS
cord-001835-0s7ok4uw	3025	51	of	of	IN
cord-001835-0s7ok4uw	3025	52	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3025	53	,	,	,
cord-001835-0s7ok4uw	3025	54	4E	4e	CD
cord-001835-0s7ok4uw	3025	55	-	-	HYPH
cord-001835-0s7ok4uw	3025	56	BP1	BP1	NNP
cord-001835-0s7ok4uw	3025	57	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	3025	58	protein	protein	NN
cord-001835-0s7ok4uw	3025	59	,	,	,
cord-001835-0s7ok4uw	3025	60	and	and	CC
cord-001835-0s7ok4uw	3026	1	the	the	DT
cord-001835-0s7ok4uw	3026	2	mRNA	mRNA	NNP
cord-001835-0s7ok4uw	3026	3	5'cap	5'cap	CD
cord-001835-0s7ok4uw	3026	4	 	 	_SP
cord-001835-0s7ok4uw	3026	5	Specific	specific	JJ
cord-001835-0s7ok4uw	3026	6	recognition	recognition	NN
cord-001835-0s7ok4uw	3026	7	of	of	IN
cord-001835-0s7ok4uw	3026	8	the	the	DT
cord-001835-0s7ok4uw	3026	9	mRNA	mRNA	NNP
cord-001835-0s7ok4uw	3026	10	5	5	CD
cord-001835-0s7ok4uw	3026	11	'	'	POS
cord-001835-0s7ok4uw	3026	12	terminal	terminal	JJ
cord-001835-0s7ok4uw	3026	13	cap	cap	NN
cord-001835-0s7ok4uw	3026	14	structure	structure	NN
cord-001835-0s7ok4uw	3026	15	by	by	IN
cord-001835-0s7ok4uw	3026	16	the	the	DT
cord-001835-0s7ok4uw	3026	17	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	3026	18	initiation	initiation	NN
cord-001835-0s7ok4uw	3026	19	factor	factor	NN
cord-001835-0s7ok4uw	3026	20	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3026	21	is	be	VBZ
cord-001835-0s7ok4uw	3026	22	the	the	DT
cord-001835-0s7ok4uw	3026	23	first	first	JJ
cord-001835-0s7ok4uw	3026	24	and	and	CC
cord-001835-0s7ok4uw	3026	25	rate	rate	NN
cord-001835-0s7ok4uw	3026	26	-	-	HYPH
cord-001835-0s7ok4uw	3026	27	limiting	limit	VBG
cord-001835-0s7ok4uw	3026	28	step	step	NN
cord-001835-0s7ok4uw	3026	29	in	in	IN
cord-001835-0s7ok4uw	3026	30	the	the	DT
cord-001835-0s7ok4uw	3026	31	cap	cap	NN
cord-001835-0s7ok4uw	3026	32	-	-	HYPH
cord-001835-0s7ok4uw	3026	33	dependent	dependent	JJ
cord-001835-0s7ok4uw	3026	34	translation	translation	NN
cord-001835-0s7ok4uw	3026	35	.	.	.
cord-001835-0s7ok4uw	3027	1	Small	small	JJ
cord-001835-0s7ok4uw	3027	2	4E	4e	NN
cord-001835-0s7ok4uw	3027	3	-	-	HYPH
cord-001835-0s7ok4uw	3027	4	binding	bind	VBG
cord-001835-0s7ok4uw	3027	5	proteins	protein	NNS
cord-001835-0s7ok4uw	3027	6	,	,	,
cord-001835-0s7ok4uw	3027	7	4E	4e	NN
cord-001835-0s7ok4uw	3027	8	-	-	HYPH
cord-001835-0s7ok4uw	3027	9	BP1	BP1	NNP
cord-001835-0s7ok4uw	3027	10	,	,	,
cord-001835-0s7ok4uw	3027	11	4E	4e	NN
cord-001835-0s7ok4uw	3027	12	-	-	:
cord-001835-0s7ok4uw	3027	13	BP2	BP2	NNP
cord-001835-0s7ok4uw	3027	14	,	,	,
cord-001835-0s7ok4uw	3027	15	and	and	CC
cord-001835-0s7ok4uw	3027	16	4E	4E	NNP
cord-001835-0s7ok4uw	3027	17	-	-	HYPH
cord-001835-0s7ok4uw	3027	18	BP3	BP3	NNP
cord-001835-0s7ok4uw	3027	19	,	,	,
cord-001835-0s7ok4uw	3027	20	inhibit	inhibit	VB
cord-001835-0s7ok4uw	3027	21	the	the	DT
cord-001835-0s7ok4uw	3027	22	translation	translation	NN
cord-001835-0s7ok4uw	3027	23	initiation	initiation	NN
cord-001835-0s7ok4uw	3027	24	by	by	IN
cord-001835-0s7ok4uw	3027	25	competing	compete	VBG
cord-001835-0s7ok4uw	3027	26	with	with	IN
cord-001835-0s7ok4uw	3027	27	eIF4	eIF4	NNP
cord-001835-0s7ok4uw	3027	28	G	g	NN
cord-001835-0s7ok4uw	3027	29	initiation	initiation	NN
cord-001835-0s7ok4uw	3027	30	factor	factor	NN
cord-001835-0s7ok4uw	3027	31	for	for	IN
cord-001835-0s7ok4uw	3027	32	the	the	DT
cord-001835-0s7ok4uw	3027	33	same	same	JJ
cord-001835-0s7ok4uw	3027	34	binding	binding	NN
cord-001835-0s7ok4uw	3027	35	site	site	NN
cord-001835-0s7ok4uw	3027	36	,	,	,
cord-001835-0s7ok4uw	3027	37	and	and	CC
cord-001835-0s7ok4uw	3027	38	by	by	IN
cord-001835-0s7ok4uw	3027	39	blocking	block	VBG
cord-001835-0s7ok4uw	3027	40	the	the	DT
cord-001835-0s7ok4uw	3027	41	assembly	assembly	NN
cord-001835-0s7ok4uw	3027	42	of	of	IN
cord-001835-0s7ok4uw	3027	43	the	the	DT
cord-001835-0s7ok4uw	3027	44	translation	translation	NN
cord-001835-0s7ok4uw	3027	45	machinery	machinery	NN
cord-001835-0s7ok4uw	3027	46	[	[	-LRB-
cord-001835-0s7ok4uw	3027	47	1	1	CD
cord-001835-0s7ok4uw	3027	48	]	]	-RRB-
cord-001835-0s7ok4uw	3027	49	.	.	.
cord-001835-0s7ok4uw	3028	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3028	2	recent	recent	JJ
cord-001835-0s7ok4uw	3028	3	studies	study	NNS
cord-001835-0s7ok4uw	3028	4	revealed	reveal	VBD
cord-001835-0s7ok4uw	3028	5	intricate	intricate	JJ
cord-001835-0s7ok4uw	3028	6	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	3028	7	between	between	IN
cord-001835-0s7ok4uw	3028	8	the	the	DT
cord-001835-0s7ok4uw	3028	9	cap	cap	NN
cord-001835-0s7ok4uw	3028	10	and	and	CC
cord-001835-0s7ok4uw	3028	11	4E	4e	JJ
cord-001835-0s7ok4uw	3028	12	-	-	HYPH
cord-001835-0s7ok4uw	3028	13	BP1	BP1	NNP
cord-001835-0s7ok4uw	3028	14	binding	bind	VBG
cord-001835-0s7ok4uw	3028	15	sites	site	NNS
cord-001835-0s7ok4uw	3028	16	of	of	IN
cord-001835-0s7ok4uw	3028	17	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3028	18	[	[	-LRB-
cord-001835-0s7ok4uw	3028	19	2	2	CD
cord-001835-0s7ok4uw	3028	20	]	]	-RRB-
cord-001835-0s7ok4uw	3028	21	.	.	.
cord-001835-0s7ok4uw	3029	1	Here	here	RB
cord-001835-0s7ok4uw	3029	2	,	,	,
cord-001835-0s7ok4uw	3029	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3029	4	applied	apply	VBD
cord-001835-0s7ok4uw	3029	5	a	a	DT
cord-001835-0s7ok4uw	3029	6	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	3029	7	dye	dye	NN
cord-001835-0s7ok4uw	3029	8	,	,	,
cord-001835-0s7ok4uw	3029	9	4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonate	4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonate	CD
cord-001835-0s7ok4uw	3029	10	(	(	-LRB-
cord-001835-0s7ok4uw	3029	11	bis	bis	NNP
cord-001835-0s7ok4uw	3029	12	-	-	HYPH
cord-001835-0s7ok4uw	3029	13	ANS	ANS	NNP
cord-001835-0s7ok4uw	3029	14	)	)	-RRB-
cord-001835-0s7ok4uw	3029	15	to	to	TO
cord-001835-0s7ok4uw	3029	16	investigate	investigate	VB
cord-001835-0s7ok4uw	3029	17	conformational	conformational	JJ
cord-001835-0s7ok4uw	3029	18	changes	change	NNS
cord-001835-0s7ok4uw	3029	19	upon	upon	IN
cord-001835-0s7ok4uw	3029	20	assembly	assembly	NN
cord-001835-0s7ok4uw	3029	21	of	of	IN
cord-001835-0s7ok4uw	3029	22	binary	binary	JJ
cord-001835-0s7ok4uw	3029	23	and	and	CC
cord-001835-0s7ok4uw	3029	24	ternary	ternary	JJ
cord-001835-0s7ok4uw	3029	25	complexes	complex	NNS
cord-001835-0s7ok4uw	3029	26	composed	compose	VBN
cord-001835-0s7ok4uw	3029	27	of	of	IN
cord-001835-0s7ok4uw	3029	28	human	human	JJ
cord-001835-0s7ok4uw	3029	29	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3029	30	,	,	,
cord-001835-0s7ok4uw	3029	31	4E	4E	NNP
cord-001835-0s7ok4uw	3029	32	-	-	HYPH
cord-001835-0s7ok4uw	3029	33	BP1	BP1	NNP
cord-001835-0s7ok4uw	3029	34	,	,	,
cord-001835-0s7ok4uw	3029	35	and	and	CC
cord-001835-0s7ok4uw	3029	36	the	the	DT
cord-001835-0s7ok4uw	3029	37	mRNA	mRNA	NNP
cord-001835-0s7ok4uw	3029	38	5'cap	5'cap	CD
cord-001835-0s7ok4uw	3029	39	analogue	analogue	NN
cord-001835-0s7ok4uw	3029	40	,	,	,
cord-001835-0s7ok4uw	3029	41	m7GTP	m7GTP	NNP
cord-001835-0s7ok4uw	3029	42	.	.	.
cord-001835-0s7ok4uw	3030	1	The	the	DT
cord-001835-0s7ok4uw	3030	2	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3030	3	quantum	quantum	NN
cord-001835-0s7ok4uw	3030	4	yield	yield	NN
cord-001835-0s7ok4uw	3030	5	of	of	IN
cord-001835-0s7ok4uw	3030	6	bis	bis	NNP
cord-001835-0s7ok4uw	3030	7	-	-	HYPH
cord-001835-0s7ok4uw	3030	8	ANS	ANS	NNP
cord-001835-0s7ok4uw	3030	9	increases	increase	VBZ
cord-001835-0s7ok4uw	3030	10	significantly	significantly	RB
cord-001835-0s7ok4uw	3030	11	upon	upon	IN
cord-001835-0s7ok4uw	3030	12	binding	bind	VBG
cord-001835-0s7ok4uw	3030	13	to	to	IN
cord-001835-0s7ok4uw	3030	14	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3030	15	sites	site	NNS
cord-001835-0s7ok4uw	3030	16	of	of	IN
cord-001835-0s7ok4uw	3030	17	proteins	protein	NNS
cord-001835-0s7ok4uw	3030	18	,	,	,
cord-001835-0s7ok4uw	3030	19	making	make	VBG
cord-001835-0s7ok4uw	3030	20	the	the	DT
cord-001835-0s7ok4uw	3030	21	probe	probe	NN
cord-001835-0s7ok4uw	3030	22	a	a	DT
cord-001835-0s7ok4uw	3030	23	convenient	convenient	JJ
cord-001835-0s7ok4uw	3030	24	tool	tool	NN
cord-001835-0s7ok4uw	3030	25	to	to	TO
cord-001835-0s7ok4uw	3030	26	determine	determine	VB
cord-001835-0s7ok4uw	3030	27	the	the	DT
cord-001835-0s7ok4uw	3030	28	accessibility	accessibility	NN
cord-001835-0s7ok4uw	3030	29	to	to	IN
cord-001835-0s7ok4uw	3030	30	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3030	31	surfaces	surface	NNS
cord-001835-0s7ok4uw	3030	32	,	,	,
cord-001835-0s7ok4uw	3030	33	and	and	CC
cord-001835-0s7ok4uw	3030	34	to	to	TO
cord-001835-0s7ok4uw	3030	35	monitor	monitor	VB
cord-001835-0s7ok4uw	3030	36	structural	structural	JJ
cord-001835-0s7ok4uw	3030	37	reorganisation	reorganisation	NN
cord-001835-0s7ok4uw	3030	38	of	of	IN
cord-001835-0s7ok4uw	3030	39	macromolecules	macromolecule	NNS
cord-001835-0s7ok4uw	3030	40	[	[	-LRB-
cord-001835-0s7ok4uw	3030	41	3	3	CD
cord-001835-0s7ok4uw	3030	42	]	]	-RRB-
cord-001835-0s7ok4uw	3030	43	.	.	.
cord-001835-0s7ok4uw	3031	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3031	2	characterised	characterise	VBD
cord-001835-0s7ok4uw	3031	3	the	the	DT
cord-001835-0s7ok4uw	3031	4	interaction	interaction	NN
cord-001835-0s7ok4uw	3031	5	of	of	IN
cord-001835-0s7ok4uw	3031	6	bis	bis	NNP
cord-001835-0s7ok4uw	3031	7	-	-	HYPH
cord-001835-0s7ok4uw	3031	8	ANS	an	NNS
cord-001835-0s7ok4uw	3031	9	with	with	IN
cord-001835-0s7ok4uw	3031	10	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3031	11	and	and	CC
cord-001835-0s7ok4uw	3031	12	4E	4e	NN
cord-001835-0s7ok4uw	3031	13	-	-	HYPH
cord-001835-0s7ok4uw	3031	14	BP1	BP1	NNP
cord-001835-0s7ok4uw	3031	15	by	by	IN
cord-001835-0s7ok4uw	3031	16	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3031	17	titration	titration	NN
cord-001835-0s7ok4uw	3031	18	.	.	.
cord-001835-0s7ok4uw	3032	1	The	the	DT
cord-001835-0s7ok4uw	3032	2	association	association	NN
cord-001835-0s7ok4uw	3032	3	processes	process	VBZ
cord-001835-0s7ok4uw	3032	4	takes	take	VBZ
cord-001835-0s7ok4uw	3032	5	up	up	RP
cord-001835-0s7ok4uw	3032	6	to	to	IN
cord-001835-0s7ok4uw	3032	7	several	several	JJ
cord-001835-0s7ok4uw	3032	8	hours	hour	NNS
cord-001835-0s7ok4uw	3032	9	until	until	IN
cord-001835-0s7ok4uw	3032	10	the	the	DT
cord-001835-0s7ok4uw	3032	11	saturation	saturation	NN
cord-001835-0s7ok4uw	3032	12	of	of	IN
cord-001835-0s7ok4uw	3032	13	the	the	DT
cord-001835-0s7ok4uw	3032	14	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3032	15	signal	signal	NN
cord-001835-0s7ok4uw	3032	16	is	be	VBZ
cord-001835-0s7ok4uw	3032	17	achieved	achieve	VBN
cord-001835-0s7ok4uw	3032	18	,	,	,
cord-001835-0s7ok4uw	3032	19	reflecting	reflect	VBG
cord-001835-0s7ok4uw	3032	20	high	high	JJ
cord-001835-0s7ok4uw	3032	21	flexibility	flexibility	NN
cord-001835-0s7ok4uw	3032	22	of	of	IN
cord-001835-0s7ok4uw	3032	23	the	the	DT
cord-001835-0s7ok4uw	3032	24	protein	protein	NN
cord-001835-0s7ok4uw	3032	25	structures	structure	NNS
cord-001835-0s7ok4uw	3032	26	.	.	.
cord-001835-0s7ok4uw	3033	1	The	the	DT
cord-001835-0s7ok4uw	3033	2	association	association	NN
cord-001835-0s7ok4uw	3033	3	constants	constant	VBZ
cord-001835-0s7ok4uw	3033	4	Kas	Kas	NNP
cord-001835-0s7ok4uw	3033	5	of	of	IN
cord-001835-0s7ok4uw	3033	6	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3033	7	/	/	SYM
cord-001835-0s7ok4uw	3033	8	bis	bis	NNP
cord-001835-0s7ok4uw	3033	9	-	-	HYPH
cord-001835-0s7ok4uw	3033	10	ANS	ANS	NNP
cord-001835-0s7ok4uw	3033	11	complexes	complex	NNS
cord-001835-0s7ok4uw	3033	12	are	be	VBP
cord-001835-0s7ok4uw	3033	13	very	very	RB
cord-001835-0s7ok4uw	3033	14	high	high	JJ
cord-001835-0s7ok4uw	3033	15	for	for	IN
cord-001835-0s7ok4uw	3033	16	the	the	DT
cord-001835-0s7ok4uw	3033	17	non	non	JJ
cord-001835-0s7ok4uw	3033	18	-	-	JJ
cord-001835-0s7ok4uw	3033	19	specific	specific	JJ
cord-001835-0s7ok4uw	3033	20	interaction	interaction	NN
cord-001835-0s7ok4uw	3033	21	.	.	.
cord-001835-0s7ok4uw	3034	1	The	the	DT
cord-001835-0s7ok4uw	3034	2	Kas	Kas	NNP
cord-001835-0s7ok4uw	3034	3	values	value	VBZ
cord-001835-0s7ok4uw	3034	4	for	for	IN
cord-001835-0s7ok4uw	3034	5	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3034	6	/	/	SYM
cord-001835-0s7ok4uw	3034	7	bis	bis	NN
cord-001835-0s7ok4uw	3034	8	-	-	HYPH
cord-001835-0s7ok4uw	3034	9	ANS	an	NNS
cord-001835-0s7ok4uw	3034	10	and	and	CC
cord-001835-0s7ok4uw	3034	11	eIF4E/4E	eIF4E/4E	NNP
cord-001835-0s7ok4uw	3034	12	-	-	HYPH
cord-001835-0s7ok4uw	3034	13	BP1	BP1	NNP
cord-001835-0s7ok4uw	3034	14	/	/	SYM
cord-001835-0s7ok4uw	3034	15	bis	bis	NNP
cord-001835-0s7ok4uw	3034	16	-	-	HYPH
cord-001835-0s7ok4uw	3034	17	ANS	ANS	NNP
cord-001835-0s7ok4uw	3034	18	are	be	VBP
cord-001835-0s7ok4uw	3034	19	similar	similar	JJ
cord-001835-0s7ok4uw	3034	20	(	(	-LRB-
cord-001835-0s7ok4uw	3034	21	10	10	CD
cord-001835-0s7ok4uw	3034	22	7	7	CD
cord-001835-0s7ok4uw	3034	23	M	M	NNP
cord-001835-0s7ok4uw	3034	24	21	21	CD
cord-001835-0s7ok4uw	3034	25	)	)	-RRB-
cord-001835-0s7ok4uw	3034	26	,	,	,
cord-001835-0s7ok4uw	3034	27	whereas	whereas	IN
cord-001835-0s7ok4uw	3034	28	the	the	DT
cord-001835-0s7ok4uw	3034	29	presence	presence	NN
cord-001835-0s7ok4uw	3034	30	of	of	IN
cord-001835-0s7ok4uw	3034	31	m7GTP	m7GTP	NNP
cord-001835-0s7ok4uw	3034	32	results	result	NNS
cord-001835-0s7ok4uw	3034	33	in	in	IN
cord-001835-0s7ok4uw	3034	34	ca	ca	NNP
cord-001835-0s7ok4uw	3034	35	.	.	.
cord-001835-0s7ok4uw	3035	1	5-fold	5-fold	CD
cord-001835-0s7ok4uw	3035	2	weaker	weak	JJR
cord-001835-0s7ok4uw	3035	3	binding	binding	NN
cord-001835-0s7ok4uw	3035	4	of	of	IN
cord-001835-0s7ok4uw	3035	5	the	the	DT
cord-001835-0s7ok4uw	3035	6	probe	probe	NN
cord-001835-0s7ok4uw	3035	7	to	to	IN
cord-001835-0s7ok4uw	3035	8	eIF4E.	eIF4E.	.
cord-001835-0s7ok4uw	3036	1	The	the	DT
cord-001835-0s7ok4uw	3036	2	affinity	affinity	NN
cord-001835-0s7ok4uw	3036	3	of	of	IN
cord-001835-0s7ok4uw	3036	4	bis	bis	NNP
cord-001835-0s7ok4uw	3036	5	-	-	HYPH
cord-001835-0s7ok4uw	3036	6	ANS	ANS	NNP
cord-001835-0s7ok4uw	3036	7	for	for	IN
cord-001835-0s7ok4uw	3036	8	4E	4e	NN
cord-001835-0s7ok4uw	3036	9	-	-	HYPH
cord-001835-0s7ok4uw	3036	10	BP1	BP1	NNP
cord-001835-0s7ok4uw	3036	11	is	be	VBZ
cord-001835-0s7ok4uw	3036	12	10-fold	10-fold	JJ
cord-001835-0s7ok4uw	3036	13	lower	low	JJR
cord-001835-0s7ok4uw	3036	14	than	than	IN
cord-001835-0s7ok4uw	3036	15	that	that	DT
cord-001835-0s7ok4uw	3036	16	for	for	IN
cord-001835-0s7ok4uw	3036	17	eIF4E.	eIF4E.	.
cord-001835-0s7ok4uw	3037	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3037	2	found	find	VBD
cord-001835-0s7ok4uw	3037	3	no	no	DT
cord-001835-0s7ok4uw	3037	4	effect	effect	NN
cord-001835-0s7ok4uw	3037	5	of	of	IN
cord-001835-0s7ok4uw	3037	6	either	either	DT
cord-001835-0s7ok4uw	3037	7	m7GTP	m7GTP	NNP
cord-001835-0s7ok4uw	3037	8	or	or	CC
cord-001835-0s7ok4uw	3037	9	4E	4e	NN
cord-001835-0s7ok4uw	3037	10	-	-	HYPH
cord-001835-0s7ok4uw	3037	11	BP1	BP1	NNP
cord-001835-0s7ok4uw	3037	12	on	on	IN
cord-001835-0s7ok4uw	3037	13	the	the	DT
cord-001835-0s7ok4uw	3037	14	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3037	15	of	of	IN
cord-001835-0s7ok4uw	3037	16	bis	bis	NNP
cord-001835-0s7ok4uw	3037	17	-	-	HYPH
cord-001835-0s7ok4uw	3037	18	ANS	ANS	NNP
cord-001835-0s7ok4uw	3037	19	in	in	IN
cord-001835-0s7ok4uw	3037	20	complex	complex	NN
cord-001835-0s7ok4uw	3037	21	with	with	IN
cord-001835-0s7ok4uw	3037	22	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3037	23	,	,	,
cord-001835-0s7ok4uw	3037	24	thus	thus	RB
cord-001835-0s7ok4uw	3037	25	indicating	indicate	VBG
cord-001835-0s7ok4uw	3037	26	lack	lack	NN
cord-001835-0s7ok4uw	3037	27	of	of	IN
cord-001835-0s7ok4uw	3037	28	conformational	conformational	JJ
cord-001835-0s7ok4uw	3037	29	changes	change	NNS
cord-001835-0s7ok4uw	3037	30	around	around	IN
cord-001835-0s7ok4uw	3037	31	the	the	DT
cord-001835-0s7ok4uw	3037	32	probe	probe	NN
cord-001835-0s7ok4uw	3037	33	on	on	IN
cord-001835-0s7ok4uw	3037	34	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3037	35	/	/	SYM
cord-001835-0s7ok4uw	3037	36	m7GTP	m7GTP	NNP
cord-001835-0s7ok4uw	3037	37	or	or	CC
cord-001835-0s7ok4uw	3037	38	eIF4E/4E	eIF4E/4E	NNP
cord-001835-0s7ok4uw	3037	39	-	-	HYPH
cord-001835-0s7ok4uw	3037	40	BP1	BP1	NNP
cord-001835-0s7ok4uw	3037	41	complex	complex	JJ
cord-001835-0s7ok4uw	3037	42	formation	formation	NN
cord-001835-0s7ok4uw	3037	43	.	.	.
cord-001835-0s7ok4uw	3038	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3038	2	also	also	RB
cord-001835-0s7ok4uw	3038	3	testifies	testify	VBZ
cord-001835-0s7ok4uw	3038	4	that	that	IN
cord-001835-0s7ok4uw	3038	5	bis	bis	NNP
cord-001835-0s7ok4uw	3038	6	-	-	HYPH
cord-001835-0s7ok4uw	3038	7	ANS	ANS	NNP
cord-001835-0s7ok4uw	3038	8	does	do	VBZ
cord-001835-0s7ok4uw	3038	9	not	not	RB
cord-001835-0s7ok4uw	3038	10	bind	bind	VB
cord-001835-0s7ok4uw	3038	11	to	to	IN
cord-001835-0s7ok4uw	3038	12	the	the	DT
cord-001835-0s7ok4uw	3038	13	cap	cap	NN
cord-001835-0s7ok4uw	3038	14	-	-	HYPH
cord-001835-0s7ok4uw	3038	15	binding	bind	VBG
cord-001835-0s7ok4uw	3038	16	site	site	NN
cord-001835-0s7ok4uw	3038	17	,	,	,
cord-001835-0s7ok4uw	3038	18	despite	despite	IN
cord-001835-0s7ok4uw	3038	19	the	the	DT
cord-001835-0s7ok4uw	3038	20	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3038	21	nature	nature	NN
cord-001835-0s7ok4uw	3038	22	of	of	IN
cord-001835-0s7ok4uw	3038	23	this	this	DT
cord-001835-0s7ok4uw	3038	24	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3038	25	region	region	NN
cord-001835-0s7ok4uw	3038	26	.	.	.
cord-001835-0s7ok4uw	3039	1	On	on	IN
cord-001835-0s7ok4uw	3039	2	the	the	DT
cord-001835-0s7ok4uw	3039	3	contrary	contrary	NN
cord-001835-0s7ok4uw	3039	4	,	,	,
cord-001835-0s7ok4uw	3039	5	addition	addition	NN
cord-001835-0s7ok4uw	3039	6	of	of	IN
cord-001835-0s7ok4uw	3039	7	m7GTP	m7GTP	NNP
cord-001835-0s7ok4uw	3039	8	to	to	IN
cord-001835-0s7ok4uw	3039	9	the	the	DT
cord-001835-0s7ok4uw	3039	10	eIF4E/4E	eIF4E/4E	NNP
cord-001835-0s7ok4uw	3039	11	-	-	HYPH
cord-001835-0s7ok4uw	3039	12	BP1	BP1	NNP
cord-001835-0s7ok4uw	3039	13	/	/	SYM
cord-001835-0s7ok4uw	3039	14	bis	bis	NNP
cord-001835-0s7ok4uw	3039	15	-	-	HYPH
cord-001835-0s7ok4uw	3039	16	ANS	ANS	NNP
cord-001835-0s7ok4uw	3039	17	complex	complex	NN
cord-001835-0s7ok4uw	3039	18	causes	cause	VBZ
cord-001835-0s7ok4uw	3039	19	an	an	DT
cord-001835-0s7ok4uw	3039	20	increase	increase	NN
cord-001835-0s7ok4uw	3039	21	of	of	IN
cord-001835-0s7ok4uw	3039	22	the	the	DT
cord-001835-0s7ok4uw	3039	23	probe	probe	NN
cord-001835-0s7ok4uw	3039	24	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3039	25	,	,	,
cord-001835-0s7ok4uw	3039	26	which	which	WDT
cord-001835-0s7ok4uw	3039	27	indicates	indicate	VBZ
cord-001835-0s7ok4uw	3039	28	differences	difference	NNS
cord-001835-0s7ok4uw	3039	29	in	in	IN
cord-001835-0s7ok4uw	3039	30	the	the	DT
cord-001835-0s7ok4uw	3039	31	structural	structural	JJ
cord-001835-0s7ok4uw	3039	32	reorganisation	reorganisation	NN
cord-001835-0s7ok4uw	3039	33	in	in	IN
cord-001835-0s7ok4uw	3039	34	the	the	DT
cord-001835-0s7ok4uw	3039	35	binary	binary	NN
cord-001835-0s7ok4uw	3039	36	,	,	,
cord-001835-0s7ok4uw	3039	37	m7GTP	m7GTP	NNP
cord-001835-0s7ok4uw	3039	38	/	/	SYM
cord-001835-0s7ok4uw	3039	39	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3039	40	,	,	,
cord-001835-0s7ok4uw	3039	41	compared	compare	VBN
cord-001835-0s7ok4uw	3039	42	with	with	IN
cord-001835-0s7ok4uw	3039	43	the	the	DT
cord-001835-0s7ok4uw	3039	44	ternary	ternary	JJ
cord-001835-0s7ok4uw	3039	45	,	,	,
cord-001835-0s7ok4uw	3039	46	m7GTP	m7GTP	NNP
cord-001835-0s7ok4uw	3039	47	/	/	SYM
cord-001835-0s7ok4uw	3039	48	eIF4E/4E	eIF4E/4E	NNP
cord-001835-0s7ok4uw	3039	49	-	-	HYPH
cord-001835-0s7ok4uw	3039	50	BP1	BP1	NNP
cord-001835-0s7ok4uw	3039	51	,	,	,
cord-001835-0s7ok4uw	3039	52	complexes	complex	NNS
cord-001835-0s7ok4uw	3039	53	,	,	,
cord-001835-0s7ok4uw	3039	54	and	and	CC
cord-001835-0s7ok4uw	3039	55	confirms	confirm	VBZ
cord-001835-0s7ok4uw	3039	56	the	the	DT
cord-001835-0s7ok4uw	3039	57	spatial	spatial	JJ
cord-001835-0s7ok4uw	3039	58	cooperation	cooperation	NN
cord-001835-0s7ok4uw	3039	59	between	between	IN
cord-001835-0s7ok4uw	3039	60	the	the	DT
cord-001835-0s7ok4uw	3039	61	cap	cap	NN
cord-001835-0s7ok4uw	3039	62	and	and	CC
cord-001835-0s7ok4uw	3039	63	4E	4e	JJ
cord-001835-0s7ok4uw	3039	64	-	-	HYPH
cord-001835-0s7ok4uw	3039	65	BP1	BP1	NNP
cord-001835-0s7ok4uw	3039	66	binding	bind	VBG
cord-001835-0s7ok4uw	3039	67	sites	site	NNS
cord-001835-0s7ok4uw	3039	68	.	.	.
cord-001835-0s7ok4uw	3040	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3040	2	also	also	RB
cord-001835-0s7ok4uw	3040	3	observed	observe	VBD
cord-001835-0s7ok4uw	3040	4	an	an	DT
cord-001835-0s7ok4uw	3040	5	increase	increase	NN
cord-001835-0s7ok4uw	3040	6	of	of	IN
cord-001835-0s7ok4uw	3040	7	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3040	8	for	for	IN
cord-001835-0s7ok4uw	3040	9	bis	bis	NNP
cord-001835-0s7ok4uw	3040	10	-	-	HYPH
cord-001835-0s7ok4uw	3040	11	ANS	an	NNS
cord-001835-0s7ok4uw	3040	12	bound	bind	VBN
cord-001835-0s7ok4uw	3040	13	to	to	IN
cord-001835-0s7ok4uw	3040	14	4E	4e	JJ
cord-001835-0s7ok4uw	3040	15	-	-	:
cord-001835-0s7ok4uw	3040	16	BP1	BP1	NNP
cord-001835-0s7ok4uw	3040	17	in	in	IN
cord-001835-0s7ok4uw	3040	18	the	the	DT
cord-001835-0s7ok4uw	3040	19	presence	presence	NN
cord-001835-0s7ok4uw	3040	20	of	of	IN
cord-001835-0s7ok4uw	3040	21	eIF4E	eif4e	CD
cord-001835-0s7ok4uw	3040	22	,	,	,
cord-001835-0s7ok4uw	3040	23	pointing	point	VBG
cord-001835-0s7ok4uw	3040	24	out	out	RP
cord-001835-0s7ok4uw	3040	25	that	that	IN
cord-001835-0s7ok4uw	3040	26	4E	4e	NN
cord-001835-0s7ok4uw	3040	27	-	-	:
cord-001835-0s7ok4uw	3040	28	BP1	BP1	NNP
cord-001835-0s7ok4uw	3040	29	partially	partially	RB
cord-001835-0s7ok4uw	3040	30	folds	fold	VBZ
cord-001835-0s7ok4uw	3040	31	upon	upon	IN
cord-001835-0s7ok4uw	3040	32	association	association	NN
cord-001835-0s7ok4uw	3040	33	with	with	IN
cord-001835-0s7ok4uw	3040	34	eIF4E.	eIF4E.	.
cord-001835-0s7ok4uw	3041	1	In	in	IN
cord-001835-0s7ok4uw	3041	2	summary	summary	NN
cord-001835-0s7ok4uw	3041	3	,	,	,
cord-001835-0s7ok4uw	3041	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3041	5	results	result	NNS
cord-001835-0s7ok4uw	3041	6	provide	provide	VBP
cord-001835-0s7ok4uw	3041	7	a	a	DT
cord-001835-0s7ok4uw	3041	8	deeper	deep	JJR
cord-001835-0s7ok4uw	3041	9	insight	insight	NN
cord-001835-0s7ok4uw	3041	10	into	into	IN
cord-001835-0s7ok4uw	3041	11	the	the	DT
cord-001835-0s7ok4uw	3041	12	structural	structural	JJ
cord-001835-0s7ok4uw	3041	13	aspects	aspect	NNS
cord-001835-0s7ok4uw	3041	14	of	of	IN
cord-001835-0s7ok4uw	3041	15	the	the	DT
cord-001835-0s7ok4uw	3041	16	molecular	molecular	JJ
cord-001835-0s7ok4uw	3041	17	interaction	interaction	NN
cord-001835-0s7ok4uw	3041	18	at	at	IN
cord-001835-0s7ok4uw	3041	19	early	early	JJ
cord-001835-0s7ok4uw	3041	20	stages	stage	NNS
cord-001835-0s7ok4uw	3041	21	of	of	IN
cord-001835-0s7ok4uw	3041	22	the	the	DT
cord-001835-0s7ok4uw	3041	23	cap	cap	NN
cord-001835-0s7ok4uw	3041	24	-	-	HYPH
cord-001835-0s7ok4uw	3041	25	dependent	dependent	JJ
cord-001835-0s7ok4uw	3041	26	translation	translation	NN
cord-001835-0s7ok4uw	3041	27	.	.	.
cord-001835-0s7ok4uw	3042	1	Acknowledgements	acknowledgement	NNS
cord-001835-0s7ok4uw	3042	2	:	:	:
cord-001835-0s7ok4uw	3043	1	This	this	DT
cord-001835-0s7ok4uw	3043	2	work	work	NN
cord-001835-0s7ok4uw	3043	3	was	be	VBD
cord-001835-0s7ok4uw	3043	4	supported	support	VBN
cord-001835-0s7ok4uw	3043	5	by	by	IN
cord-001835-0s7ok4uw	3043	6	the	the	DT
cord-001835-0s7ok4uw	3043	7	BST	BST	NNP
cord-001835-0s7ok4uw	3043	8	170000	170000	CD
cord-001835-0s7ok4uw	3043	9	/	/	SYM
cord-001835-0s7ok4uw	3043	10	BF	BF	NNP
cord-001835-0s7ok4uw	3043	11	project	project	NN
cord-001835-0s7ok4uw	3043	12	from	from	IN
cord-001835-0s7ok4uw	3043	13	University	University	NNP
cord-001835-0s7ok4uw	3043	14	of	of	IN
cord-001835-0s7ok4uw	3043	15	Warsaw	Warsaw	NNP
cord-001835-0s7ok4uw	3043	16	Background	Background	NNP
cord-001835-0s7ok4uw	3043	17	:	:	:
cord-001835-0s7ok4uw	3043	18	Beta2-Glycoprotein	Beta2-Glycoprotein	NNP
cord-001835-0s7ok4uw	3043	19	(	(	-LRB-
cord-001835-0s7ok4uw	3043	20	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3043	21	)	)	-RRB-
cord-001835-0s7ok4uw	3043	22	is	be	VBZ
cord-001835-0s7ok4uw	3043	23	a	a	DT
cord-001835-0s7ok4uw	3043	24	protein	protein	NN
cord-001835-0s7ok4uw	3043	25	abundantly	abundantly	RB
cord-001835-0s7ok4uw	3043	26	present	present	JJ
cord-001835-0s7ok4uw	3043	27	in	in	IN
cord-001835-0s7ok4uw	3043	28	human	human	JJ
cord-001835-0s7ok4uw	3043	29	plasma	plasma	NN
cord-001835-0s7ok4uw	3043	30	and	and	CC
cord-001835-0s7ok4uw	3043	31	highly	highly	RB
cord-001835-0s7ok4uw	3043	32	conserved	conserve	VBN
cord-001835-0s7ok4uw	3043	33	in	in	IN
cord-001835-0s7ok4uw	3043	34	all	all	DT
cord-001835-0s7ok4uw	3043	35	mammals	mammal	NNS
cord-001835-0s7ok4uw	3043	36	.	.	.
cord-001835-0s7ok4uw	3044	1	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3044	2	has	have	VBZ
cord-001835-0s7ok4uw	3044	3	been	be	VBN
cord-001835-0s7ok4uw	3044	4	identified	identify	VBN
cord-001835-0s7ok4uw	3044	5	as	as	IN
cord-001835-0s7ok4uw	3044	6	the	the	DT
cord-001835-0s7ok4uw	3044	7	major	major	JJ
cord-001835-0s7ok4uw	3044	8	antigen	antigen	NN
cord-001835-0s7ok4uw	3044	9	in	in	IN
cord-001835-0s7ok4uw	3044	10	the	the	DT
cord-001835-0s7ok4uw	3044	11	antiphospholipid	antiphospholipid	NNP
cord-001835-0s7ok4uw	3044	12	syndrome	syndrome	NN
cord-001835-0s7ok4uw	3044	13	(	(	-LRB-
cord-001835-0s7ok4uw	3044	14	APS	APS	NNP
cord-001835-0s7ok4uw	3044	15	)	)	-RRB-
cord-001835-0s7ok4uw	3044	16	,	,	,
cord-001835-0s7ok4uw	3044	17	a	a	DT
cord-001835-0s7ok4uw	3044	18	severe	severe	JJ
cord-001835-0s7ok4uw	3044	19	thrombotic	thrombotic	JJ
cord-001835-0s7ok4uw	3044	20	autoimmune	autoimmune	JJ
cord-001835-0s7ok4uw	3044	21	disease	disease	NN
cord-001835-0s7ok4uw	3044	22	.	.	.
cord-001835-0s7ok4uw	3045	1	Despite	despite	IN
cord-001835-0s7ok4uw	3045	2	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3045	3	importance	importance	NN
cord-001835-0s7ok4uw	3045	4	in	in	IN
cord-001835-0s7ok4uw	3045	5	the	the	DT
cord-001835-0s7ok4uw	3045	6	pathogenesis	pathogenesis	NN
cord-001835-0s7ok4uw	3045	7	of	of	IN
cord-001835-0s7ok4uw	3045	8	APS	APS	NNP
cord-001835-0s7ok4uw	3045	9	,	,	,
cord-001835-0s7ok4uw	3045	10	the	the	DT
cord-001835-0s7ok4uw	3045	11	physiological	physiological	JJ
cord-001835-0s7ok4uw	3045	12	role	role	NN
cord-001835-0s7ok4uw	3045	13	of	of	IN
cord-001835-0s7ok4uw	3045	14	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3045	15	is	be	VBZ
cord-001835-0s7ok4uw	3045	16	still	still	RB
cord-001835-0s7ok4uw	3045	17	elusive	elusive	JJ
cord-001835-0s7ok4uw	3045	18	.	.	.
cord-001835-0s7ok4uw	3046	1	In	in	IN
cord-001835-0s7ok4uw	3046	2	a	a	DT
cord-001835-0s7ok4uw	3046	3	previous	previous	JJ
cord-001835-0s7ok4uw	3046	4	work	work	NN
cord-001835-0s7ok4uw	3046	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3046	6	have	have	VBP
cord-001835-0s7ok4uw	3046	7	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	3046	8	that	that	IN
cord-001835-0s7ok4uw	3046	9	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3046	10	significantly	significantly	RB
cord-001835-0s7ok4uw	3046	11	prolongs	prolong	VBZ
cord-001835-0s7ok4uw	3046	12	the	the	DT
cord-001835-0s7ok4uw	3046	13	clotting	clotting	NN
cord-001835-0s7ok4uw	3046	14	time	time	NN
cord-001835-0s7ok4uw	3046	15	in	in	IN
cord-001835-0s7ok4uw	3046	16	fibrin	fibrin	NN
cord-001835-0s7ok4uw	3046	17	generation	generation	NN
cord-001835-0s7ok4uw	3046	18	assays	assay	NNS
cord-001835-0s7ok4uw	3046	19	,	,	,
cord-001835-0s7ok4uw	3046	20	and	and	CC
cord-001835-0s7ok4uw	3046	21	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	3046	22	aggregation	aggregation	NN
cord-001835-0s7ok4uw	3046	23	of	of	IN
cord-001835-0s7ok4uw	3046	24	gel	gel	NN
cord-001835-0s7ok4uw	3046	25	-	-	HYPH
cord-001835-0s7ok4uw	3046	26	filtered	filter	VBN
cord-001835-0s7ok4uw	3046	27	platelets	platelet	NNS
cord-001835-0s7ok4uw	3046	28	(	(	-LRB-
cord-001835-0s7ok4uw	3046	29	IC5050.36uM	IC5050.36uM	NNP
cord-001835-0s7ok4uw	3046	30	)	)	-RRB-
cord-001835-0s7ok4uw	3046	31	,	,	,
cord-001835-0s7ok4uw	3046	32	either	either	CC
cord-001835-0s7ok4uw	3046	33	isolated	isolated	JJ
cord-001835-0s7ok4uw	3046	34	or	or	CC
cord-001835-0s7ok4uw	3046	35	in	in	IN
cord-001835-0s7ok4uw	3046	36	whole	whole	JJ
cord-001835-0s7ok4uw	3046	37	blood	blood	NN
cord-001835-0s7ok4uw	3046	38	,	,	,
cord-001835-0s7ok4uw	3046	39	by	by	IN
cord-001835-0s7ok4uw	3046	40	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	3046	41	cleavage	cleavage	NN
cord-001835-0s7ok4uw	3046	42	of	of	IN
cord-001835-0s7ok4uw	3046	43	PAR1	PAR1	NNP
cord-001835-0s7ok4uw	3046	44	on	on	IN
cord-001835-0s7ok4uw	3046	45	intact	intact	JJ
cord-001835-0s7ok4uw	3046	46	platelets	platelet	NNS
cord-001835-0s7ok4uw	3046	47	(	(	-LRB-
cord-001835-0s7ok4uw	3046	48	IC5050.32uM	IC5050.32uM	NNP
cord-001835-0s7ok4uw	3046	49	)	)	-RRB-
cord-001835-0s7ok4uw	3046	50	and	and	CC
cord-001835-0s7ok4uw	3046	51	in	in	IN
cord-001835-0s7ok4uw	3046	52	solution	solution	NN
cord-001835-0s7ok4uw	3046	53	.	.	.
cord-001835-0s7ok4uw	3047	1	Importantly	importantly	RB
cord-001835-0s7ok4uw	3047	2	,	,	,
cord-001835-0s7ok4uw	3047	3	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3047	4	does	do	VBZ
cord-001835-0s7ok4uw	3047	5	not	not	RB
cord-001835-0s7ok4uw	3047	6	alter	alter	VB
cord-001835-0s7ok4uw	3047	7	the	the	DT
cord-001835-0s7ok4uw	3047	8	ability	ability	NN
cord-001835-0s7ok4uw	3047	9	of	of	IN
cord-001835-0s7ok4uw	3047	10	thrombin	thrombin	NN
cord-001835-0s7ok4uw	3047	11	(	(	-LRB-
cord-001835-0s7ok4uw	3047	12	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	3047	13	)	)	-RRB-
cord-001835-0s7ok4uw	3047	14	to	to	TO
cord-001835-0s7ok4uw	3047	15	generate	generate	VB
cord-001835-0s7ok4uw	3047	16	the	the	DT
cord-001835-0s7ok4uw	3047	17	anticoagulant	anticoagulant	JJ
cord-001835-0s7ok4uw	3047	18	protein	protein	NN
cord-001835-0s7ok4uw	3047	19	C	C	NNP
cord-001835-0s7ok4uw	3047	20	,	,	,
cord-001835-0s7ok4uw	3047	21	with	with	IN
cord-001835-0s7ok4uw	3047	22	or	or	CC
cord-001835-0s7ok4uw	3047	23	without	without	IN
cord-001835-0s7ok4uw	3047	24	thrombomodulin	thrombomodulin	NNP
cord-001835-0s7ok4uw	3047	25	added	add	VBD
cord-001835-0s7ok4uw	3047	26	.	.	.
cord-001835-0s7ok4uw	3048	1	Hence	hence	RB
cord-001835-0s7ok4uw	3048	2	,	,	,
cord-001835-0s7ok4uw	3048	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3048	4	concluded	conclude	VBD
cord-001835-0s7ok4uw	3048	5	that	that	IN
cord-001835-0s7ok4uw	3048	6	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3048	7	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	3048	8	the	the	DT
cord-001835-0s7ok4uw	3048	9	key	key	JJ
cord-001835-0s7ok4uw	3048	10	procoagulant	procoagulant	NN
cord-001835-0s7ok4uw	3048	11	properties	property	NNS
cord-001835-0s7ok4uw	3048	12	of	of	IN
cord-001835-0s7ok4uw	3048	13	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	3048	14	,	,	,
cord-001835-0s7ok4uw	3048	15	without	without	IN
cord-001835-0s7ok4uw	3048	16	affecting	affect	VBG
cord-001835-0s7ok4uw	3048	17	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3048	18	unique	unique	JJ
cord-001835-0s7ok4uw	3048	19	anticoagulant	anticoagulant	JJ
cord-001835-0s7ok4uw	3048	20	function	function	NN
cord-001835-0s7ok4uw	3048	21	.	.	.
cord-001835-0s7ok4uw	3049	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3049	2	also	also	RB
cord-001835-0s7ok4uw	3049	3	proposed	propose	VBD
cord-001835-0s7ok4uw	3049	4	that	that	IN
cord-001835-0s7ok4uw	3049	5	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3049	6	,	,	,
cord-001835-0s7ok4uw	3049	7	together	together	RB
cord-001835-0s7ok4uw	3049	8	with	with	IN
cord-001835-0s7ok4uw	3049	9	other	other	JJ
cord-001835-0s7ok4uw	3049	10	more	more	RBR
cord-001835-0s7ok4uw	3049	11	efficient	efficient	JJ
cord-001835-0s7ok4uw	3049	12	anticoagulant	anticoagulant	JJ
cord-001835-0s7ok4uw	3049	13	pathways	pathway	NNS
cord-001835-0s7ok4uw	3049	14	such	such	JJ
cord-001835-0s7ok4uw	3049	15	as	as	IN
cord-001835-0s7ok4uw	3049	16	thrombomodulin	thrombomodulin	NNP
cord-001835-0s7ok4uw	3049	17	-	-	HYPH
cord-001835-0s7ok4uw	3049	18	FIIa	FIIa	NNP
cord-001835-0s7ok4uw	3049	19	-protein	-protein	CC
cord-001835-0s7ok4uw	3049	20	C	C	NNP
cord-001835-0s7ok4uw	3049	21	and	and	CC
cord-001835-0s7ok4uw	3049	22	antithrombin	antithrombin	NN
cord-001835-0s7ok4uw	3049	23	III	III	NNP
cord-001835-0s7ok4uw	3049	24	-	-	HYPH
cord-001835-0s7ok4uw	3049	25	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	3049	26	,	,	,
cord-001835-0s7ok4uw	3049	27	may	may	MD
cord-001835-0s7ok4uw	3049	28	function	function	VB
cord-001835-0s7ok4uw	3049	29	as	as	IN
cord-001835-0s7ok4uw	3049	30	a	a	DT
cord-001835-0s7ok4uw	3049	31	mild	mild	JJ
cord-001835-0s7ok4uw	3049	32	anticoagulant	anticoagulant	NN
cord-001835-0s7ok4uw	3049	33	in	in	IN
cord-001835-0s7ok4uw	3049	34	vivo	vivo	NN
cord-001835-0s7ok4uw	3049	35	especially	especially	RB
cord-001835-0s7ok4uw	3049	36	in	in	IN
cord-001835-0s7ok4uw	3049	37	those	those	DT
cord-001835-0s7ok4uw	3049	38	compartments	compartment	NNS
cord-001835-0s7ok4uw	3049	39	were	be	VBD
cord-001835-0s7ok4uw	3049	40	the	the	DT
cord-001835-0s7ok4uw	3049	41	efficacy	efficacy	NN
cord-001835-0s7ok4uw	3049	42	of	of	IN
cord-001835-0s7ok4uw	3049	43	thrombomodulin	thrombomodulin	NNP
cord-001835-0s7ok4uw	3049	44	is	be	VBZ
cord-001835-0s7ok4uw	3049	45	limited	limit	VBN
cord-001835-0s7ok4uw	3049	46	,	,	,
cord-001835-0s7ok4uw	3049	47	as	as	IN
cord-001835-0s7ok4uw	3049	48	in	in	IN
cord-001835-0s7ok4uw	3049	49	the	the	DT
cord-001835-0s7ok4uw	3049	50	large	large	JJ
cord-001835-0s7ok4uw	3049	51	vessels	vessel	NNS
cord-001835-0s7ok4uw	3049	52	,	,	,
cord-001835-0s7ok4uw	3049	53	or	or	CC
cord-001835-0s7ok4uw	3049	54	is	be	VBZ
cord-001835-0s7ok4uw	3049	55	even	even	RB
cord-001835-0s7ok4uw	3049	56	absent	absent	JJ
cord-001835-0s7ok4uw	3049	57	,	,	,
cord-001835-0s7ok4uw	3049	58	as	as	IN
cord-001835-0s7ok4uw	3049	59	in	in	IN
cord-001835-0s7ok4uw	3049	60	the	the	DT
cord-001835-0s7ok4uw	3049	61	brain	brain	NN
cord-001835-0s7ok4uw	3049	62	vasculature	vasculature	NN
cord-001835-0s7ok4uw	3049	63	.	.	.
cord-001835-0s7ok4uw	3050	1	Aims	aim	VBZ
cord-001835-0s7ok4uw	3050	2	:	:	:
cord-001835-0s7ok4uw	3051	1	Lacking	lack	VBG
cord-001835-0s7ok4uw	3051	2	the	the	DT
cord-001835-0s7ok4uw	3051	3	threedimensional	threedimensional	JJ
cord-001835-0s7ok4uw	3051	4	structure	structure	NN
cord-001835-0s7ok4uw	3051	5	of	of	IN
cord-001835-0s7ok4uw	3051	6	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3051	7	-	-	HYPH
cord-001835-0s7ok4uw	3051	8	thrombin	thrombin	NN
cord-001835-0s7ok4uw	3051	9	complex	complex	NN
cord-001835-0s7ok4uw	3051	10	,	,	,
cord-001835-0s7ok4uw	3051	11	the	the	DT
cord-001835-0s7ok4uw	3051	12	aim	aim	NN
cord-001835-0s7ok4uw	3051	13	of	of	IN
cord-001835-0s7ok4uw	3051	14	this	this	DT
cord-001835-0s7ok4uw	3051	15	work	work	NN
cord-001835-0s7ok4uw	3051	16	is	be	VBZ
cord-001835-0s7ok4uw	3051	17	to	to	TO
cord-001835-0s7ok4uw	3051	18	identify	identify	VB
cord-001835-0s7ok4uw	3051	19	the	the	DT
cord-001835-0s7ok4uw	3051	20	peptide	peptide	NN
cord-001835-0s7ok4uw	3051	21	regions	region	NNS
cord-001835-0s7ok4uw	3051	22	either	either	CC
cord-001835-0s7ok4uw	3051	23	on	on	IN
cord-001835-0s7ok4uw	3051	24	thrombin	thrombin	NN
cord-001835-0s7ok4uw	3051	25	and	and	CC
cord-001835-0s7ok4uw	3051	26	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3051	27	involved	involve	VBN
cord-001835-0s7ok4uw	3051	28	in	in	IN
cord-001835-0s7ok4uw	3051	29	complex	complex	JJ
cord-001835-0s7ok4uw	3051	30	formation	formation	NN
cord-001835-0s7ok4uw	3051	31	.	.	.
cord-001835-0s7ok4uw	3052	1	Results	result	NNS
cord-001835-0s7ok4uw	3052	2	:	:	:
cord-001835-0s7ok4uw	3053	1	Data	datum	NNS
cord-001835-0s7ok4uw	3053	2	obtained	obtain	VBN
cord-001835-0s7ok4uw	3053	3	by	by	IN
cord-001835-0s7ok4uw	3053	4	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3053	5	and	and	CC
cord-001835-0s7ok4uw	3053	6	surface	surface	NN
cord-001835-0s7ok4uw	3053	7	plasmon	plasmon	JJ
cord-001835-0s7ok4uw	3053	8	resonance	resonance	NN
cord-001835-0s7ok4uw	3053	9	(	(	-LRB-
cord-001835-0s7ok4uw	3053	10	SPR	SPR	NNP
cord-001835-0s7ok4uw	3053	11	)	)	-RRB-
cord-001835-0s7ok4uw	3053	12	indicated	indicate	VBD
cord-001835-0s7ok4uw	3053	13	that	that	IN
cord-001835-0s7ok4uw	3053	14	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3053	15	interacts	interact	VBZ
cord-001835-0s7ok4uw	3053	16	whit	whit	NNP
cord-001835-0s7ok4uw	3053	17	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	3053	18	whit	whit	VBP
cord-001835-0s7ok4uw	3053	19	physiological	physiological	JJ
cord-001835-0s7ok4uw	3053	20	affinity	affinity	NN
cord-001835-0s7ok4uw	3053	21	(	(	-LRB-
cord-001835-0s7ok4uw	3053	22	Kd543	kd543	RB
cord-001835-0s7ok4uw	3053	23	6	6	CD
cord-001835-0s7ok4uw	3053	24	4nM	4nm	CD
cord-001835-0s7ok4uw	3053	25	)	)	-RRB-
cord-001835-0s7ok4uw	3053	26	.	.	.
cord-001835-0s7ok4uw	3054	1	Kd	Kd	NNP
cord-001835-0s7ok4uw	3054	2	values	value	NNS
cord-001835-0s7ok4uw	3054	3	calculated	calculate	VBN
cord-001835-0s7ok4uw	3054	4	by	by	IN
cord-001835-0s7ok4uw	3054	5	reverting	revert	VBG
cord-001835-0s7ok4uw	3054	6	the	the	DT
cord-001835-0s7ok4uw	3054	7	interacting	interact	VBG
cord-001835-0s7ok4uw	3054	8	systems	system	NNS
cord-001835-0s7ok4uw	3054	9	are	be	VBP
cord-001835-0s7ok4uw	3054	10	very	very	RB
cord-001835-0s7ok4uw	3054	11	similar	similar	JJ
cord-001835-0s7ok4uw	3054	12	to	to	IN
cord-001835-0s7ok4uw	3054	13	each	each	DT
cord-001835-0s7ok4uw	3054	14	other	other	JJ
cord-001835-0s7ok4uw	3055	1	(	(	-LRB-
cord-001835-0s7ok4uw	3055	2	Kd598	Kd598	NNP
cord-001835-0s7ok4uw	3055	3	6	6	CD
cord-001835-0s7ok4uw	3055	4	9nM	9nm	CD
cord-001835-0s7ok4uw	3055	5	)	)	-RRB-
cord-001835-0s7ok4uw	3055	6	,	,	.
cord-001835-0s7ok4uw	3056	1	suggesting	suggest	VBG
cord-001835-0s7ok4uw	3056	2	that	that	IN
cord-001835-0s7ok4uw	3056	3	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3056	4	in	in	IN
cord-001835-0s7ok4uw	3056	5	the	the	DT
cord-001835-0s7ok4uw	3056	6	mobile	mobile	JJ
cord-001835-0s7ok4uw	3056	7	phase	phase	NN
cord-001835-0s7ok4uw	3056	8	has	have	VBZ
cord-001835-0s7ok4uw	3056	9	a	a	DT
cord-001835-0s7ok4uw	3056	10	conformation	conformation	NN
cord-001835-0s7ok4uw	3056	11	which	which	WDT
cord-001835-0s7ok4uw	3056	12	is	be	VBZ
cord-001835-0s7ok4uw	3056	13	competent	competent	JJ
cord-001835-0s7ok4uw	3056	14	for	for	IN
cord-001835-0s7ok4uw	3056	15	the	the	DT
cord-001835-0s7ok4uw	3056	16	binding	binding	NN
cord-001835-0s7ok4uw	3056	17	to	to	IN
cord-001835-0s7ok4uw	3056	18	immobilized	immobilized	JJ
cord-001835-0s7ok4uw	3056	19	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	3056	20	.	.	.
cord-001835-0s7ok4uw	3057	1	The	the	DT
cord-001835-0s7ok4uw	3057	2	affinity	affinity	NN
cord-001835-0s7ok4uw	3057	3	of	of	IN
cord-001835-0s7ok4uw	3057	4	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	3057	5	for	for	IN
cord-001835-0s7ok4uw	3057	6	immobilized	immobilize	VBN
cord-001835-0s7ok4uw	3057	7	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3057	8	is	be	VBZ
cord-001835-0s7ok4uw	3057	9	markedly	markedly	RB
cord-001835-0s7ok4uw	3057	10	decreased	decrease	VBN
cord-001835-0s7ok4uw	3057	11	by	by	IN
cord-001835-0s7ok4uw	3057	12	increased	increase	VBN
cord-001835-0s7ok4uw	3057	13	ionic	ionic	JJ
cord-001835-0s7ok4uw	3057	14	strength	strength	NN
cord-001835-0s7ok4uw	3057	15	(	(	-LRB-
cord-001835-0s7ok4uw	3057	16	i.e.	i.e.	FW
cord-001835-0s7ok4uw	3057	17	Kd	Kd	NNP
cord-001835-0s7ok4uw	3057	18	increases	increase	VBZ
cord-001835-0s7ok4uw	3057	19	by	by	IN
cord-001835-0s7ok4uw	3057	20	50-fold	50-fold	CD
cord-001835-0s7ok4uw	3057	21	going	go	VBG
cord-001835-0s7ok4uw	3057	22	from	from	IN
cord-001835-0s7ok4uw	3057	23	0.1	0.1	CD
cord-001835-0s7ok4uw	3057	24	M	M	NNP
cord-001835-0s7ok4uw	3057	25	to	to	IN
cord-001835-0s7ok4uw	3057	26	0.4	0.4	CD
cord-001835-0s7ok4uw	3057	27	M	M	NNP
cord-001835-0s7ok4uw	3057	28	)	)	-RRB-
cord-001835-0s7ok4uw	3057	29	,	,	,
cord-001835-0s7ok4uw	3057	30	suggesting	suggest	VBG
cord-001835-0s7ok4uw	3057	31	the	the	DT
cord-001835-0s7ok4uw	3057	32	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	3057	33	interactions	interaction	NNS
cord-001835-0s7ok4uw	3057	34	play	play	VBP
cord-001835-0s7ok4uw	3057	35	a	a	DT
cord-001835-0s7ok4uw	3057	36	key	key	JJ
cord-001835-0s7ok4uw	3057	37	role	role	NN
cord-001835-0s7ok4uw	3057	38	in	in	IN
cord-001835-0s7ok4uw	3057	39	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	3057	40	-B2GpI	-B2GpI	NNP
cord-001835-0s7ok4uw	3057	41	recognition	recognition	NN
cord-001835-0s7ok4uw	3057	42	.	.	.
cord-001835-0s7ok4uw	3058	1	Filling	filling	NN
cord-001835-0s7ok4uw	3058	2	/	/	SYM
cord-001835-0s7ok4uw	3058	3	inactivation	inactivation	NN
cord-001835-0s7ok4uw	3058	4	or	or	CC
cord-001835-0s7ok4uw	3058	5	perturbation	perturbation	NN
cord-001835-0s7ok4uw	3058	6	of	of	IN
cord-001835-0s7ok4uw	3058	7	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	3058	8	active	active	JJ
cord-001835-0s7ok4uw	3058	9	site	site	NN
cord-001835-0s7ok4uw	3058	10	does	do	VBZ
cord-001835-0s7ok4uw	3058	11	not	not	RB
cord-001835-0s7ok4uw	3058	12	alter	alter	VB
cord-001835-0s7ok4uw	3058	13	the	the	DT
cord-001835-0s7ok4uw	3058	14	affinity	affinity	NN
cord-001835-0s7ok4uw	3058	15	of	of	IN
cord-001835-0s7ok4uw	3058	16	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	3058	17	for	for	IN
cord-001835-0s7ok4uw	3058	18	immobilized	immobilize	VBN
cord-001835-0s7ok4uw	3058	19	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3058	20	,	,	,
cord-001835-0s7ok4uw	3058	21	confirming	confirm	VBG
cord-001835-0s7ok4uw	3058	22	that	that	IN
cord-001835-0s7ok4uw	3058	23	the	the	DT
cord-001835-0s7ok4uw	3058	24	active	active	JJ
cord-001835-0s7ok4uw	3058	25	site	site	NN
cord-001835-0s7ok4uw	3058	26	is	be	VBZ
cord-001835-0s7ok4uw	3058	27	not	not	RB
cord-001835-0s7ok4uw	3058	28	involved	involve	VBN
cord-001835-0s7ok4uw	3058	29	in	in	IN
cord-001835-0s7ok4uw	3058	30	the	the	DT
cord-001835-0s7ok4uw	3058	31	interaction	interaction	NN
cord-001835-0s7ok4uw	3058	32	.	.	.
cord-001835-0s7ok4uw	3059	1	Mapping	mapping	NN
cord-001835-0s7ok4uw	3059	2	of	of	IN
cord-001835-0s7ok4uw	3059	3	thrombin	thrombin	JJ
cord-001835-0s7ok4uw	3059	4	binding	bind	VBG
cord-001835-0s7ok4uw	3059	5	sites	site	NNS
cord-001835-0s7ok4uw	3059	6	with	with	IN
cord-001835-0s7ok4uw	3059	7	specific	specific	JJ
cord-001835-0s7ok4uw	3059	8	exosite	exosite	NN
cord-001835-0s7ok4uw	3059	9	-	-	HYPH
cord-001835-0s7ok4uw	3059	10	directed	direct	VBN
cord-001835-0s7ok4uw	3059	11	ligands	ligand	NNS
cord-001835-0s7ok4uw	3059	12	(	(	-LRB-
cord-001835-0s7ok4uw	3059	13	i.e.	i.e.	FW
cord-001835-0s7ok4uw	3059	14	hirugen	hirugen	NNP
cord-001835-0s7ok4uw	3059	15	,	,	,
cord-001835-0s7ok4uw	3059	16	GpIbalpha	GpIbalpha	NNP
cord-001835-0s7ok4uw	3059	17	,	,	,
cord-001835-0s7ok4uw	3059	18	HD1	HD1	VBZ
cord-001835-0s7ok4uw	3059	19	aptamer	aptamer	NNP
cord-001835-0s7ok4uw	3059	20	)	)	-RRB-
cord-001835-0s7ok4uw	3059	21	and	and	CC
cord-001835-0s7ok4uw	3059	22	thrombin	thrombin	JJ
cord-001835-0s7ok4uw	3059	23	analogues	analogue	NNS
cord-001835-0s7ok4uw	3059	24	having	have	VBG
cord-001835-0s7ok4uw	3059	25	the	the	DT
cord-001835-0s7ok4uw	3059	26	exosites	exosite	NNS
cord-001835-0s7ok4uw	3059	27	variably	variably	RB
cord-001835-0s7ok4uw	3059	28	compromised	compromise	VBN
cord-001835-0s7ok4uw	3059	29	(	(	-LRB-
cord-001835-0s7ok4uw	3059	30	i.e.	i.e.	FW
cord-001835-0s7ok4uw	3059	31	prothrombin	prothrombin	NN
cord-001835-0s7ok4uw	3059	32	,	,	,
cord-001835-0s7ok4uw	3059	33	prethrombin-2	prethrombin-2	RB
cord-001835-0s7ok4uw	3059	34	,	,	,
cord-001835-0s7ok4uw	3059	35	alpha	alpha	NN
cord-001835-0s7ok4uw	3059	36	-	-	HYPH
cord-001835-0s7ok4uw	3059	37	thrombin	thrombin	JJ
cord-001835-0s7ok4uw	3059	38	)	)	-RRB-
cord-001835-0s7ok4uw	3059	39	,	,	,
cord-001835-0s7ok4uw	3059	40	reveals	reveal	VBZ
cord-001835-0s7ok4uw	3059	41	that	that	IN
cord-001835-0s7ok4uw	3059	42	the	the	DT
cord-001835-0s7ok4uw	3059	43	positively	positively	RB
cord-001835-0s7ok4uw	3059	44	charged	charge	VBN
cord-001835-0s7ok4uw	3059	45	exosite	exosite	NNP
cord-001835-0s7ok4uw	3059	46	-	-	HYPH
cord-001835-0s7ok4uw	3059	47	II	II	NNP
cord-001835-0s7ok4uw	3059	48	of	of	IN
cord-001835-0s7ok4uw	3059	49	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	3059	50	plays	play	VBZ
cord-001835-0s7ok4uw	3059	51	a	a	DT
cord-001835-0s7ok4uw	3059	52	key	key	JJ
cord-001835-0s7ok4uw	3059	53	role	role	NN
cord-001835-0s7ok4uw	3059	54	in	in	IN
cord-001835-0s7ok4uw	3059	55	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3059	56	binding	binding	NN
cord-001835-0s7ok4uw	3059	57	.	.	.
cord-001835-0s7ok4uw	3060	1	From	from	IN
cord-001835-0s7ok4uw	3060	2	the	the	DT
cord-001835-0s7ok4uw	3060	3	docking	docking	NN
cord-001835-0s7ok4uw	3060	4	model	model	NN
cord-001835-0s7ok4uw	3060	5	of	of	IN
cord-001835-0s7ok4uw	3060	6	the	the	DT
cord-001835-0s7ok4uw	3060	7	bB2GpI	bb2gpi	JJ
cord-001835-0s7ok4uw	3060	8	-	-	HYPH
cord-001835-0s7ok4uw	3060	9	thrombin	thrombin	JJ
cord-001835-0s7ok4uw	3060	10	complex	complex	NN
cord-001835-0s7ok4uw	3060	11	,	,	,
cord-001835-0s7ok4uw	3060	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	3060	13	identified	identify	VBD
cord-001835-0s7ok4uw	3060	14	a	a	DT
cord-001835-0s7ok4uw	3060	15	highly	highly	RB
cord-001835-0s7ok4uw	3060	16	negatively	negatively	RB
cord-001835-0s7ok4uw	3060	17	charged	charge	VBN
cord-001835-0s7ok4uw	3060	18	segment	segment	NN
cord-001835-0s7ok4uw	3060	19	219	219	CD
cord-001835-0s7ok4uw	3060	20	-	-	SYM
cord-001835-0s7ok4uw	3060	21	232	232	CD
cord-001835-0s7ok4uw	3060	22	in	in	IN
cord-001835-0s7ok4uw	3060	23	domain	domain	NN
cord-001835-0s7ok4uw	3060	24	V	v	NN
cord-001835-0s7ok4uw	3060	25	of	of	IN
cord-001835-0s7ok4uw	3060	26	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3060	27	interacting	interact	VBG
cord-001835-0s7ok4uw	3060	28	with	with	IN
cord-001835-0s7ok4uw	3060	29	positively	positively	RB
cord-001835-0s7ok4uw	3060	30	charged	charge	VBN
cord-001835-0s7ok4uw	3060	31	pathes	pathe	NNS
cord-001835-0s7ok4uw	3060	32	in	in	IN
cord-001835-0s7ok4uw	3060	33	thrombin	thrombin	NN
cord-001835-0s7ok4uw	3060	34	exosite	exosite	NNP
cord-001835-0s7ok4uw	3060	35	II	II	NNP
cord-001835-0s7ok4uw	3060	36	.	.	.
cord-001835-0s7ok4uw	3061	1	The	the	DT
cord-001835-0s7ok4uw	3061	2	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3061	3	peptide	peptide	NN
cord-001835-0s7ok4uw	3061	4	B2GpI(219	B2GpI(219	NNS
cord-001835-0s7ok4uw	3061	5	-	-	:
cord-001835-0s7ok4uw	3061	6	232	232	CD
cord-001835-0s7ok4uw	3061	7	)	)	-RRB-
cord-001835-0s7ok4uw	3061	8	was	be	VBD
cord-001835-0s7ok4uw	3061	9	able	able	JJ
cord-001835-0s7ok4uw	3061	10	to	to	TO
cord-001835-0s7ok4uw	3061	11	bind	bind	VB
cord-001835-0s7ok4uw	3061	12	to	to	IN
cord-001835-0s7ok4uw	3061	13	FIIa	FIIa	NNS
cord-001835-0s7ok4uw	3061	14	with	with	IN
cord-001835-0s7ok4uw	3061	15	an	an	DT
cord-001835-0s7ok4uw	3061	16	affinity	affinity	NN
cord-001835-0s7ok4uw	3061	17	(	(	-LRB-
cord-001835-0s7ok4uw	3061	18	Kd538	Kd538	NNP
cord-001835-0s7ok4uw	3061	19	6	6	CD
cord-001835-0s7ok4uw	3061	20	9nM	9nm	CD
cord-001835-0s7ok4uw	3061	21	)	)	-RRB-
cord-001835-0s7ok4uw	3061	22	comparable	comparable	JJ
cord-001835-0s7ok4uw	3061	23	to	to	IN
cord-001835-0s7ok4uw	3061	24	that	that	DT
cord-001835-0s7ok4uw	3061	25	of	of	IN
cord-001835-0s7ok4uw	3061	26	full	full	JJ
cord-001835-0s7ok4uw	3061	27	-	-	HYPH
cord-001835-0s7ok4uw	3061	28	length	length	NN
cord-001835-0s7ok4uw	3061	29	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3061	30	,	,	,
cord-001835-0s7ok4uw	3061	31	deduced	deduce	VBN
cord-001835-0s7ok4uw	3061	32	from	from	IN
cord-001835-0s7ok4uw	3061	33	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3061	34	or	or	CC
cord-001835-0s7ok4uw	3061	35	SPR	SPR	NNP
cord-001835-0s7ok4uw	3061	36	measurements	measurement	NNS
cord-001835-0s7ok4uw	3061	37	and	and	CC
cord-001835-0s7ok4uw	3061	38	to	to	TO
cord-001835-0s7ok4uw	3061	39	compete	compete	VB
cord-001835-0s7ok4uw	3061	40	in	in	IN
cord-001835-0s7ok4uw	3061	41	SPR	SPR	NNP
cord-001835-0s7ok4uw	3061	42	measueremnts	measueremnt	NNS
cord-001835-0s7ok4uw	3061	43	with	with	IN
cord-001835-0s7ok4uw	3061	44	the	the	DT
cord-001835-0s7ok4uw	3061	45	binding	binding	NN
cord-001835-0s7ok4uw	3061	46	of	of	IN
cord-001835-0s7ok4uw	3061	47	full	full	JJ
cord-001835-0s7ok4uw	3061	48	-	-	HYPH
cord-001835-0s7ok4uw	3061	49	length	length	NN
cord-001835-0s7ok4uw	3061	50	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3061	51	to	to	IN
cord-001835-0s7ok4uw	3061	52	thrombin	thrombin	NN
cord-001835-0s7ok4uw	3061	53	.	.	.
cord-001835-0s7ok4uw	3062	1	Hence	hence	RB
cord-001835-0s7ok4uw	3062	2	,	,	,
cord-001835-0s7ok4uw	3062	3	combining	combine	VBG
cord-001835-0s7ok4uw	3062	4	experimental	experimental	JJ
cord-001835-0s7ok4uw	3062	5	and	and	CC
cord-001835-0s7ok4uw	3062	6	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	3062	7	data	datum	NNS
cord-001835-0s7ok4uw	3062	8	,	,	,
cord-001835-0s7ok4uw	3062	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	3062	10	obtained	obtain	VBD
cord-001835-0s7ok4uw	3062	11	a	a	DT
cord-001835-0s7ok4uw	3062	12	reliable	reliable	JJ
cord-001835-0s7ok4uw	3062	13	model	model	NN
cord-001835-0s7ok4uw	3062	14	of	of	IN
cord-001835-0s7ok4uw	3062	15	the	the	DT
cord-001835-0s7ok4uw	3062	16	B2GpI	B2GpI	NNP
cord-001835-0s7ok4uw	3062	17	-	-	HYPH
cord-001835-0s7ok4uw	3062	18	thrombin	thrombin	NN
cord-001835-0s7ok4uw	3062	19	complex	complex	NN
cord-001835-0s7ok4uw	3062	20	.	.	.
cord-001835-0s7ok4uw	3063	1	Metalloproteases	metalloprotease	NNS
cord-001835-0s7ok4uw	3063	2	are	be	VBP
cord-001835-0s7ok4uw	3063	3	one	one	CD
cord-001835-0s7ok4uw	3063	4	of	of	IN
cord-001835-0s7ok4uw	3063	5	the	the	DT
cord-001835-0s7ok4uw	3063	6	most	most	RBS
cord-001835-0s7ok4uw	3063	7	diverse	diverse	JJ
cord-001835-0s7ok4uw	3063	8	types	type	NNS
cord-001835-0s7ok4uw	3063	9	of	of	IN
cord-001835-0s7ok4uw	3063	10	proteases	protease	NNS
cord-001835-0s7ok4uw	3063	11	,	,	,
cord-001835-0s7ok4uw	3063	12	presenting	present	VBG
cord-001835-0s7ok4uw	3063	13	a	a	DT
cord-001835-0s7ok4uw	3063	14	wide	wide	JJ
cord-001835-0s7ok4uw	3063	15	range	range	NN
cord-001835-0s7ok4uw	3063	16	of	of	IN
cord-001835-0s7ok4uw	3063	17	folds	fold	NNS
cord-001835-0s7ok4uw	3063	18	and	and	CC
cord-001835-0s7ok4uw	3063	19	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3063	20	metal	metal	NN
cord-001835-0s7ok4uw	3063	21	ions	ion	NNS
cord-001835-0s7ok4uw	3063	22	.	.	.
cord-001835-0s7ok4uw	3064	1	In	in	IN
cord-001835-0s7ok4uw	3064	2	the	the	DT
cord-001835-0s7ok4uw	3064	3	case	case	NN
cord-001835-0s7ok4uw	3064	4	of	of	IN
cord-001835-0s7ok4uw	3064	5	the	the	DT
cord-001835-0s7ok4uw	3064	6	MEROPS	MEROPS	NNP
cord-001835-0s7ok4uw	3064	7	MA	MA	NNP
cord-001835-0s7ok4uw	3064	8	clan	clan	NN
cord-001835-0s7ok4uw	3064	9	,	,	,
cord-001835-0s7ok4uw	3064	10	where	where	WRB
cord-001835-0s7ok4uw	3064	11	most	most	JJS
cord-001835-0s7ok4uw	3064	12	of	of	IN
cord-001835-0s7ok4uw	3064	13	the	the	DT
cord-001835-0s7ok4uw	3064	14	known	know	VBN
cord-001835-0s7ok4uw	3064	15	metalloproteases	metalloprotease	NNS
cord-001835-0s7ok4uw	3064	16	are	be	VBP
cord-001835-0s7ok4uw	3064	17	grouped	group	VBN
cord-001835-0s7ok4uw	3064	18	based	base	VBN
cord-001835-0s7ok4uw	3064	19	on	on	IN
cord-001835-0s7ok4uw	3064	20	the	the	DT
cord-001835-0s7ok4uw	3064	21	consensus	consensus	NN
cord-001835-0s7ok4uw	3064	22	HEXXH	HEXXH	NNP
cord-001835-0s7ok4uw	3064	23	sequence	sequence	NN
cord-001835-0s7ok4uw	3064	24	motif	motif	NN
cord-001835-0s7ok4uw	3064	25	,	,	,
cord-001835-0s7ok4uw	3064	26	a	a	DT
cord-001835-0s7ok4uw	3064	27	single	single	JJ
cord-001835-0s7ok4uw	3064	28	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3064	29	zinc	zinc	NN
cord-001835-0s7ok4uw	3064	30	ion	ion	NN
cord-001835-0s7ok4uw	3064	31	and	and	CC
cord-001835-0s7ok4uw	3064	32	common	common	JJ
cord-001835-0s7ok4uw	3064	33	fold	fold	NN
cord-001835-0s7ok4uw	3064	34	architecture	architecture	NN
cord-001835-0s7ok4uw	3064	35	[	[	-LRB-
cord-001835-0s7ok4uw	3064	36	1	1	CD
cord-001835-0s7ok4uw	3064	37	]	]	-RRB-
cord-001835-0s7ok4uw	3064	38	.	.	.
cord-001835-0s7ok4uw	3065	1	Despite	despite	IN
cord-001835-0s7ok4uw	3065	2	these	these	DT
cord-001835-0s7ok4uw	3065	3	common	common	JJ
cord-001835-0s7ok4uw	3065	4	features	feature	NNS
cord-001835-0s7ok4uw	3065	5	,	,	,
cord-001835-0s7ok4uw	3065	6	members	member	NNS
cord-001835-0s7ok4uw	3065	7	from	from	IN
cord-001835-0s7ok4uw	3065	8	distinct	distinct	JJ
cord-001835-0s7ok4uw	3065	9	families	family	NNS
cord-001835-0s7ok4uw	3065	10	present	present	VBP
cord-001835-0s7ok4uw	3065	11	distinct	distinct	JJ
cord-001835-0s7ok4uw	3065	12	domain	domain	NN
cord-001835-0s7ok4uw	3065	13	composition	composition	NN
cord-001835-0s7ok4uw	3065	14	and	and	CC
cord-001835-0s7ok4uw	3065	15	topology	topology	NN
cord-001835-0s7ok4uw	3065	16	.	.	.
cord-001835-0s7ok4uw	3066	1	Given	give	VBN
cord-001835-0s7ok4uw	3066	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3066	3	interest	interest	NN
cord-001835-0s7ok4uw	3066	4	in	in	IN
cord-001835-0s7ok4uw	3066	5	developing	develop	VBG
cord-001835-0s7ok4uw	3066	6	new	new	JJ
cord-001835-0s7ok4uw	3066	7	tailor	tailor	NN
cord-001835-0s7ok4uw	3066	8	-	-	HYPH
cord-001835-0s7ok4uw	3066	9	made	make	VBN
cord-001835-0s7ok4uw	3066	10	metalloproteases	metalloprotease	NNS
cord-001835-0s7ok4uw	3066	11	for	for	IN
cord-001835-0s7ok4uw	3066	12	bioengineering	bioengineering	NN
cord-001835-0s7ok4uw	3066	13	applications	application	NNS
cord-001835-0s7ok4uw	3066	14	,	,	,
cord-001835-0s7ok4uw	3066	15	an	an	DT
cord-001835-0s7ok4uw	3066	16	in	in	IN
cord-001835-0s7ok4uw	3066	17	-	-	HYPH
cord-001835-0s7ok4uw	3066	18	depth	depth	NN
cord-001835-0s7ok4uw	3066	19	understanding	understanding	NN
cord-001835-0s7ok4uw	3066	20	of	of	IN
cord-001835-0s7ok4uw	3066	21	the	the	DT
cord-001835-0s7ok4uw	3066	22	factors	factor	NNS
cord-001835-0s7ok4uw	3066	23	governing	govern	VBG
cord-001835-0s7ok4uw	3066	24	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3066	25	function	function	NN
cord-001835-0s7ok4uw	3066	26	is	be	VBZ
cord-001835-0s7ok4uw	3066	27	required	require	VBN
cord-001835-0s7ok4uw	3066	28	.	.	.
cord-001835-0s7ok4uw	3067	1	Protein	protein	NN
cord-001835-0s7ok4uw	3067	2	internal	internal	JJ
cord-001835-0s7ok4uw	3067	3	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3067	4	includes	include	VBZ
cord-001835-0s7ok4uw	3067	5	the	the	DT
cord-001835-0s7ok4uw	3067	6	space	space	NN
cord-001835-0s7ok4uw	3067	7	of	of	IN
cord-001835-0s7ok4uw	3067	8	functionally	functionally	RB
cord-001835-0s7ok4uw	3067	9	-	-	HYPH
cord-001835-0s7ok4uw	3067	10	relevant	relevant	JJ
cord-001835-0s7ok4uw	3067	11	structural	structural	JJ
cord-001835-0s7ok4uw	3067	12	changes	change	NNS
cord-001835-0s7ok4uw	3067	13	occurring	occur	VBG
cord-001835-0s7ok4uw	3067	14	during	during	IN
cord-001835-0s7ok4uw	3067	15	an	an	DT
cord-001835-0s7ok4uw	3067	16	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	3067	17	reaction	reaction	NN
cord-001835-0s7ok4uw	3067	18	,	,	,
cord-001835-0s7ok4uw	3067	19	and	and	CC
cord-001835-0s7ok4uw	3067	20	there	there	EX
cord-001835-0s7ok4uw	3067	21	is	be	VBZ
cord-001835-0s7ok4uw	3067	22	an	an	DT
cord-001835-0s7ok4uw	3067	23	increasing	increase	VBG
cord-001835-0s7ok4uw	3067	24	understanding	understanding	NN
cord-001835-0s7ok4uw	3067	25	on	on	IN
cord-001835-0s7ok4uw	3067	26	how	how	WRB
cord-001835-0s7ok4uw	3067	27	it	-PRON-	PRP
cord-001835-0s7ok4uw	3067	28	relates	relate	VBZ
cord-001835-0s7ok4uw	3067	29	with	with	IN
cord-001835-0s7ok4uw	3067	30	protein	protein	NN
cord-001835-0s7ok4uw	3067	31	sequence	sequence	NN
cord-001835-0s7ok4uw	3067	32	and	and	CC
cord-001835-0s7ok4uw	3067	33	structure	structure	NN
cord-001835-0s7ok4uw	3067	34	evolution	evolution	NN
cord-001835-0s7ok4uw	3067	35	.	.	.
cord-001835-0s7ok4uw	3068	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	3068	2	,	,	,
cord-001835-0s7ok4uw	3068	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3068	4	have	have	VBP
cord-001835-0s7ok4uw	3068	5	recently	recently	RB
cord-001835-0s7ok4uw	3068	6	assessed	assess	VBN
cord-001835-0s7ok4uw	3068	7	how	how	WRB
cord-001835-0s7ok4uw	3068	8	the	the	DT
cord-001835-0s7ok4uw	3068	9	structural	structural	JJ
cord-001835-0s7ok4uw	3068	10	heterogeneity	heterogeneity	NN
cord-001835-0s7ok4uw	3068	11	of	of	IN
cord-001835-0s7ok4uw	3068	12	metalloproteases	metalloprotease	NNS
cord-001835-0s7ok4uw	3068	13	relates	relate	VBZ
cord-001835-0s7ok4uw	3068	14	with	with	IN
cord-001835-0s7ok4uw	3068	15	the	the	DT
cord-001835-0s7ok4uw	3068	16	similarity	similarity	NN
cord-001835-0s7ok4uw	3068	17	of	of	IN
cord-001835-0s7ok4uw	3068	18	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3068	19	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	3068	20	profiles	profile	NNS
cord-001835-0s7ok4uw	3068	21	[	[	-LRB-
cord-001835-0s7ok4uw	3068	22	2	2	CD
cord-001835-0s7ok4uw	3068	23	]	]	-RRB-
cord-001835-0s7ok4uw	3068	24	.	.	.
cord-001835-0s7ok4uw	3069	1	First	first	RB
cord-001835-0s7ok4uw	3069	2	,	,	,
cord-001835-0s7ok4uw	3069	3	the	the	DT
cord-001835-0s7ok4uw	3069	4	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	3069	5	profile	profile	NN
cord-001835-0s7ok4uw	3069	6	of	of	IN
cord-001835-0s7ok4uw	3069	7	the	the	DT
cord-001835-0s7ok4uw	3069	8	clan	clan	NN
cord-001835-0s7ok4uw	3069	9	MA	MA	NNP
cord-001835-0s7ok4uw	3069	10	type	type	NN
cord-001835-0s7ok4uw	3069	11	protein	protein	NN
cord-001835-0s7ok4uw	3069	12	thermolysin	thermolysin	NNP
cord-001835-0s7ok4uw	3069	13	,	,	,
cord-001835-0s7ok4uw	3069	14	derived	derive	VBN
cord-001835-0s7ok4uw	3069	15	from	from	IN
cord-001835-0s7ok4uw	3069	16	the	the	DT
cord-001835-0s7ok4uw	3069	17	Anisotropic	Anisotropic	NNP
cord-001835-0s7ok4uw	3069	18	Network	Network	NNP
cord-001835-0s7ok4uw	3069	19	Model	Model	NNP
cord-001835-0s7ok4uw	3069	20	,	,	,
cord-001835-0s7ok4uw	3069	21	was	be	VBD
cord-001835-0s7ok4uw	3069	22	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	3069	23	and	and	CC
cord-001835-0s7ok4uw	3069	24	compared	compare	VBN
cord-001835-0s7ok4uw	3069	25	with	with	IN
cord-001835-0s7ok4uw	3069	26	those	those	DT
cord-001835-0s7ok4uw	3069	27	obtained	obtain	VBN
cord-001835-0s7ok4uw	3069	28	from	from	IN
cord-001835-0s7ok4uw	3069	29	principal	principal	JJ
cord-001835-0s7ok4uw	3069	30	component	component	NN
cord-001835-0s7ok4uw	3069	31	(	(	-LRB-
cord-001835-0s7ok4uw	3069	32	PC	pc	NN
cord-001835-0s7ok4uw	3069	33	)	)	-RRB-
cord-001835-0s7ok4uw	3069	34	analysis	analysis	NN
cord-001835-0s7ok4uw	3069	35	of	of	IN
cord-001835-0s7ok4uw	3069	36	a	a	DT
cord-001835-0s7ok4uw	3069	37	set	set	NN
cord-001835-0s7ok4uw	3069	38	of	of	IN
cord-001835-0s7ok4uw	3069	39	112	112	CD
cord-001835-0s7ok4uw	3069	40	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	3069	41	structures	structure	NNS
cord-001835-0s7ok4uw	3069	42	and	and	CC
cord-001835-0s7ok4uw	3069	43	essential	essential	JJ
cord-001835-0s7ok4uw	3069	44	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3069	45	(	(	-LRB-
cord-001835-0s7ok4uw	3069	46	ED	ED	NNP
cord-001835-0s7ok4uw	3069	47	)	)	-RRB-
cord-001835-0s7ok4uw	3069	48	analysis	analysis	NN
cord-001835-0s7ok4uw	3069	49	of	of	IN
cord-001835-0s7ok4uw	3069	50	a	a	DT
cord-001835-0s7ok4uw	3069	51	20	20	CD
cord-001835-0s7ok4uw	3069	52	ns	ns	NNP
cord-001835-0s7ok4uw	3069	53	molecular	molecular	JJ
cord-001835-0s7ok4uw	3069	54	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3069	55	simulation	simulation	NN
cord-001835-0s7ok4uw	3069	56	trajectory	trajectory	NN
cord-001835-0s7ok4uw	3069	57	[	[	-LRB-
cord-001835-0s7ok4uw	3069	58	3	3	CD
cord-001835-0s7ok4uw	3069	59	]	]	-RRB-
cord-001835-0s7ok4uw	3069	60	.	.	.
cord-001835-0s7ok4uw	3070	1	A	a	DT
cord-001835-0s7ok4uw	3070	2	close	close	JJ
cord-001835-0s7ok4uw	3070	3	correspondence	correspondence	NN
cord-001835-0s7ok4uw	3070	4	was	be	VBD
cord-001835-0s7ok4uw	3070	5	obtained	obtain	VBN
cord-001835-0s7ok4uw	3070	6	between	between	IN
cord-001835-0s7ok4uw	3070	7	normal	normal	JJ
cord-001835-0s7ok4uw	3070	8	modes	mode	NNS
cord-001835-0s7ok4uw	3070	9	(	(	-LRB-
cord-001835-0s7ok4uw	3070	10	NM	NM	NNP
cord-001835-0s7ok4uw	3070	11	)	)	-RRB-
cord-001835-0s7ok4uw	3070	12	derived	derive	VBN
cord-001835-0s7ok4uw	3070	13	from	from	IN
cord-001835-0s7ok4uw	3070	14	the	the	DT
cord-001835-0s7ok4uw	3070	15	coarse	coarse	RB
cord-001835-0s7ok4uw	3070	16	-	-	HYPH
cord-001835-0s7ok4uw	3070	17	grained	grained	JJ
cord-001835-0s7ok4uw	3070	18	model	model	NN
cord-001835-0s7ok4uw	3070	19	and	and	CC
cord-001835-0s7ok4uw	3070	20	experimentally	experimentally	RB
cord-001835-0s7ok4uw	3070	21	-	-	HYPH
cord-001835-0s7ok4uw	3070	22	observed	observe	VBN
cord-001835-0s7ok4uw	3070	23	conformational	conformational	JJ
cord-001835-0s7ok4uw	3070	24	changes	change	NNS
cord-001835-0s7ok4uw	3070	25	(	(	-LRB-
cord-001835-0s7ok4uw	3070	26	RMSIP	RMSIP	NNP
cord-001835-0s7ok4uw	3070	27	between	between	IN
cord-001835-0s7ok4uw	3070	28	NM1-NM3	NM1-NM3	NNP
cord-001835-0s7ok4uw	3070	29	and	and	CC
cord-001835-0s7ok4uw	3070	30	PC1	PC1	NNP
cord-001835-0s7ok4uw	3070	31	of	of	IN
cord-001835-0s7ok4uw	3070	32	0.81	0.81	CD
cord-001835-0s7ok4uw	3070	33	)	)	-RRB-
cord-001835-0s7ok4uw	3070	34	,	,	,
cord-001835-0s7ok4uw	3070	35	corresponding	correspond	VBG
cord-001835-0s7ok4uw	3070	36	to	to	IN
cord-001835-0s7ok4uw	3070	37	functionally	functionally	RB
cord-001835-0s7ok4uw	3070	38	-	-	HYPH
cord-001835-0s7ok4uw	3070	39	relevant	relevant	JJ
cord-001835-0s7ok4uw	3070	40	hinge	hinge	NN
cord-001835-0s7ok4uw	3070	41	bending	bend	VBG
cord-001835-0s7ok4uw	3070	42	motions	motion	NNS
cord-001835-0s7ok4uw	3070	43	that	that	WDT
cord-001835-0s7ok4uw	3070	44	were	be	VBD
cord-001835-0s7ok4uw	3070	45	shown	show	VBN
cord-001835-0s7ok4uw	3070	46	to	to	TO
cord-001835-0s7ok4uw	3070	47	be	be	VB
cord-001835-0s7ok4uw	3070	48	encoded	encode	VBN
cord-001835-0s7ok4uw	3070	49	in	in	IN
cord-001835-0s7ok4uw	3070	50	the	the	DT
cord-001835-0s7ok4uw	3070	51	internal	internal	JJ
cord-001835-0s7ok4uw	3070	52	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3070	53	of	of	IN
cord-001835-0s7ok4uw	3070	54	the	the	DT
cord-001835-0s7ok4uw	3070	55	protein	protein	NN
cord-001835-0s7ok4uw	3070	56	(	(	-LRB-
cord-001835-0s7ok4uw	3070	57	cumulative	cumulative	JJ
cord-001835-0s7ok4uw	3070	58	overlap	overlap	NN
cord-001835-0s7ok4uw	3070	59	of	of	IN
cord-001835-0s7ok4uw	3070	60	ED1-ED3	ED1-ED3	NNP
cord-001835-0s7ok4uw	3070	61	and	and	CC
cord-001835-0s7ok4uw	3070	62	PC1	PC1	NNP
cord-001835-0s7ok4uw	3070	63	of	of	IN
cord-001835-0s7ok4uw	3070	64	0.85	0.85	CD
cord-001835-0s7ok4uw	3070	65	)	)	-RRB-
cord-001835-0s7ok4uw	3070	66	.	.	.
cord-001835-0s7ok4uw	3071	1	Next	next	RB
cord-001835-0s7ok4uw	3071	2	,	,	,
cord-001835-0s7ok4uw	3071	3	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3071	4	-	-	HYPH
cord-001835-0s7ok4uw	3071	5	based	base	VBN
cord-001835-0s7ok4uw	3071	6	comparison	comparison	NN
cord-001835-0s7ok4uw	3071	7	methods	method	NNS
cord-001835-0s7ok4uw	3071	8	that	that	WDT
cord-001835-0s7ok4uw	3071	9	employ	employ	VBP
cord-001835-0s7ok4uw	3071	10	a	a	DT
cord-001835-0s7ok4uw	3071	11	related	relate	VBN
cord-001835-0s7ok4uw	3071	12	coarse	coarse	RB
cord-001835-0s7ok4uw	3071	13	-	-	HYPH
cord-001835-0s7ok4uw	3071	14	grained	grained	JJ
cord-001835-0s7ok4uw	3071	15	model	model	NN
cord-001835-0s7ok4uw	3071	16	(	(	-LRB-
cord-001835-0s7ok4uw	3071	17	b	b	NN
cord-001835-0s7ok4uw	3071	18	-	-	HYPH
cord-001835-0s7ok4uw	3071	19	Gaussian	Gaussian	NNP
cord-001835-0s7ok4uw	3071	20	Elastic	Elastic	NNP
cord-001835-0s7ok4uw	3071	21	Network	Network	NNP
cord-001835-0s7ok4uw	3071	22	Model	Model	NNP
cord-001835-0s7ok4uw	3071	23	)	)	-RRB-
cord-001835-0s7ok4uw	3071	24	was	be	VBD
cord-001835-0s7ok4uw	3071	25	made	make	VBN
cord-001835-0s7ok4uw	3071	26	for	for	IN
cord-001835-0s7ok4uw	3071	27	a	a	DT
cord-001835-0s7ok4uw	3071	28	representative	representative	JJ
cord-001835-0s7ok4uw	3071	29	set	set	NN
cord-001835-0s7ok4uw	3071	30	of	of	IN
cord-001835-0s7ok4uw	3071	31	13	13	CD
cord-001835-0s7ok4uw	3071	32	MA	MA	NNP
cord-001835-0s7ok4uw	3071	33	clan	clan	NN
cord-001835-0s7ok4uw	3071	34	members	member	NNS
cord-001835-0s7ok4uw	3071	35	[	[	-LRB-
cord-001835-0s7ok4uw	3071	36	4	4	CD
cord-001835-0s7ok4uw	3071	37	]	]	-RRB-
cord-001835-0s7ok4uw	3071	38	,	,	,
cord-001835-0s7ok4uw	3071	39	allowing	allow	VBG
cord-001835-0s7ok4uw	3071	40	for	for	IN
cord-001835-0s7ok4uw	3071	41	a	a	DT
cord-001835-0s7ok4uw	3071	42	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	3071	43	description	description	NN
cord-001835-0s7ok4uw	3071	44	of	of	IN
cord-001835-0s7ok4uw	3071	45	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3071	46	structural	structural	JJ
cord-001835-0s7ok4uw	3071	47	and	and	CC
cord-001835-0s7ok4uw	3071	48	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	3071	49	variability	variability	NN
cord-001835-0s7ok4uw	3071	50	.	.	.
cord-001835-0s7ok4uw	3072	1	Although	although	IN
cord-001835-0s7ok4uw	3072	2	members	member	NNS
cord-001835-0s7ok4uw	3072	3	are	be	VBP
cord-001835-0s7ok4uw	3072	4	structurally	structurally	RB
cord-001835-0s7ok4uw	3072	5	similar	similar	JJ
cord-001835-0s7ok4uw	3072	6	(	(	-LRB-
cord-001835-0s7ok4uw	3072	7	87	87	CD
cord-001835-0s7ok4uw	3072	8	%	%	NN
cord-001835-0s7ok4uw	3072	9	pairs	pair	NNS
cord-001835-0s7ok4uw	3072	10	with	with	IN
cord-001835-0s7ok4uw	3072	11	DaliLite	DaliLite	NNP
cord-001835-0s7ok4uw	3072	12	Z	z	NN
cord-001835-0s7ok4uw	3072	13	-	-	HYPH
cord-001835-0s7ok4uw	3072	14	score	score	NN
cord-001835-0s7ok4uw	3072	15	>	>	XX
cord-001835-0s7ok4uw	3072	16	2.0	2.0	CD
cord-001835-0s7ok4uw	3072	17	)	)	-RRB-
cord-001835-0s7ok4uw	3072	18	,	,	,
cord-001835-0s7ok4uw	3072	19	they	-PRON-	PRP
cord-001835-0s7ok4uw	3072	20	nonetheless	nonetheless	RB
cord-001835-0s7ok4uw	3072	21	present	present	VBP
cord-001835-0s7ok4uw	3072	22	distinct	distinct	JJ
cord-001835-0s7ok4uw	3072	23	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	3072	24	profiles	profile	NNS
cord-001835-0s7ok4uw	3072	25	(	(	-LRB-
cord-001835-0s7ok4uw	3072	26	69	69	CD
cord-001835-0s7ok4uw	3072	27	%	%	NN
cord-001835-0s7ok4uw	3072	28	of	of	IN
cord-001835-0s7ok4uw	3072	29	pairs	pair	NNS
cord-001835-0s7ok4uw	3072	30	with	with	IN
cord-001835-0s7ok4uw	3072	31	ALADYN	ALADYN	NNP
cord-001835-0s7ok4uw	3072	32	P	P	NNP
cord-001835-0s7ok4uw	3072	33	-	-	HYPH
cord-001835-0s7ok4uw	3072	34	value	value	NN
cord-001835-0s7ok4uw	3072	35	>	>	XX
cord-001835-0s7ok4uw	3072	36	0.02	0.02	CD
cord-001835-0s7ok4uw	3072	37	)	)	-RRB-
cord-001835-0s7ok4uw	3072	38	,	,	,
cord-001835-0s7ok4uw	3072	39	with	with	IN
cord-001835-0s7ok4uw	3072	40	no	no	DT
cord-001835-0s7ok4uw	3072	41	identified	identify	VBN
cord-001835-0s7ok4uw	3072	42	correlation	correlation	NN
cord-001835-0s7ok4uw	3072	43	between	between	IN
cord-001835-0s7ok4uw	3072	44	structural	structural	JJ
cord-001835-0s7ok4uw	3072	45	and	and	CC
cord-001835-0s7ok4uw	3072	46	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	3072	47	similarity	similarity	NN
cord-001835-0s7ok4uw	3072	48	.	.	.
cord-001835-0s7ok4uw	3073	1	For	for	IN
cord-001835-0s7ok4uw	3073	2	cases	case	NNS
cord-001835-0s7ok4uw	3073	3	where	where	WRB
cord-001835-0s7ok4uw	3073	4	high	high	JJ
cord-001835-0s7ok4uw	3073	5	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	3073	6	similarity	similarity	NN
cord-001835-0s7ok4uw	3073	7	was	be	VBD
cord-001835-0s7ok4uw	3073	8	observed	observe	VBN
cord-001835-0s7ok4uw	3073	9	,	,	,
cord-001835-0s7ok4uw	3073	10	the	the	DT
cord-001835-0s7ok4uw	3073	11	respective	respective	JJ
cord-001835-0s7ok4uw	3073	12	modes	mode	NNS
cord-001835-0s7ok4uw	3073	13	corresponded	correspond	VBD
cord-001835-0s7ok4uw	3073	14	to	to	IN
cord-001835-0s7ok4uw	3073	15	hinge	hinge	NN
cord-001835-0s7ok4uw	3073	16	-	-	HYPH
cord-001835-0s7ok4uw	3073	17	bending	bend	VBG
cord-001835-0s7ok4uw	3073	18	motions	motion	NNS
cord-001835-0s7ok4uw	3073	19	encompassing	encompass	VBG
cord-001835-0s7ok4uw	3073	20	regions	region	NNS
cord-001835-0s7ok4uw	3073	21	close	close	RB
cord-001835-0s7ok4uw	3073	22	to	to	IN
cord-001835-0s7ok4uw	3073	23	the	the	DT
cord-001835-0s7ok4uw	3073	24	active	active	JJ
cord-001835-0s7ok4uw	3073	25	site	site	NN
cord-001835-0s7ok4uw	3073	26	.	.	.
cord-001835-0s7ok4uw	3074	1	Further	further	JJ
cord-001835-0s7ok4uw	3074	2	inspection	inspection	NN
cord-001835-0s7ok4uw	3074	3	of	of	IN
cord-001835-0s7ok4uw	3074	4	the	the	DT
cord-001835-0s7ok4uw	3074	5	produced	produce	VBN
cord-001835-0s7ok4uw	3074	6	alignments	alignment	NNS
cord-001835-0s7ok4uw	3074	7	indicates	indicate	VBZ
cord-001835-0s7ok4uw	3074	8	that	that	IN
cord-001835-0s7ok4uw	3074	9	for	for	IN
cord-001835-0s7ok4uw	3074	10	MA	MA	NNP
cord-001835-0s7ok4uw	3074	11	clan	clan	NN
cord-001835-0s7ok4uw	3074	12	metalloproteases	metalloproteases	NN
cord-001835-0s7ok4uw	3074	13	,	,	,
cord-001835-0s7ok4uw	3074	14	conservation	conservation	NN
cord-001835-0s7ok4uw	3074	15	of	of	IN
cord-001835-0s7ok4uw	3074	16	internal	internal	JJ
cord-001835-0s7ok4uw	3074	17	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3074	18	has	have	VBZ
cord-001835-0s7ok4uw	3074	19	a	a	DT
cord-001835-0s7ok4uw	3074	20	functional	functional	JJ
cord-001835-0s7ok4uw	3074	21	basis	basis	NN
cord-001835-0s7ok4uw	3074	22	,	,	,
cord-001835-0s7ok4uw	3074	23	namely	namely	RB
cord-001835-0s7ok4uw	3074	24	the	the	DT
cord-001835-0s7ok4uw	3074	25	need	need	NN
cord-001835-0s7ok4uw	3074	26	for	for	IN
cord-001835-0s7ok4uw	3074	27	maintaining	maintain	VBG
cord-001835-0s7ok4uw	3074	28	proper	proper	JJ
cord-001835-0s7ok4uw	3074	29	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	3074	30	interactions	interaction	NNS
cord-001835-0s7ok4uw	3074	31	between	between	IN
cord-001835-0s7ok4uw	3074	32	the	the	DT
cord-001835-0s7ok4uw	3074	33	protein	protein	NN
cord-001835-0s7ok4uw	3074	34	and	and	CC
cord-001835-0s7ok4uw	3074	35	respective	respective	JJ
cord-001835-0s7ok4uw	3074	36	substrate	substrate	NN
cord-001835-0s7ok4uw	3074	37	.	.	.
cord-001835-0s7ok4uw	3075	1	Previously	previously	RB
cord-001835-0s7ok4uw	3075	2	unnoticed	unnoticed	JJ
cord-001835-0s7ok4uw	3075	3	dynamical	dynamical	JJ
cord-001835-0s7ok4uw	3075	4	similarity	similarity	NN
cord-001835-0s7ok4uw	3075	5	between	between	IN
cord-001835-0s7ok4uw	3075	6	clan	clan	NN
cord-001835-0s7ok4uw	3075	7	members	member	NNS
cord-001835-0s7ok4uw	3075	8	Botulinum	Botulinum	NNP
cord-001835-0s7ok4uw	3075	9	Neurotoxin	Neurotoxin	NNP
cord-001835-0s7ok4uw	3075	10	Type	Type	NNP
cord-001835-0s7ok4uw	3075	11	A	A	NNP
cord-001835-0s7ok4uw	3075	12	,	,	,
cord-001835-0s7ok4uw	3075	13	Leishmanolysin	Leishmanolysin	NNP
cord-001835-0s7ok4uw	3075	14	and	and	CC
cord-001835-0s7ok4uw	3075	15	Carboxypeptidase	Carboxypeptidase	NNP
cord-001835-0s7ok4uw	3075	16	Pfu	Pfu	NNP
cord-001835-0s7ok4uw	3075	17	was	be	VBD
cord-001835-0s7ok4uw	3075	18	also	also	RB
cord-001835-0s7ok4uw	3075	19	found	find	VBN
cord-001835-0s7ok4uw	3075	20	.	.	.
cord-001835-0s7ok4uw	3076	1	Together	together	RB
cord-001835-0s7ok4uw	3076	2	,	,	,
cord-001835-0s7ok4uw	3076	3	these	these	DT
cord-001835-0s7ok4uw	3076	4	results	result	NNS
cord-001835-0s7ok4uw	3076	5	suggest	suggest	VBP
cord-001835-0s7ok4uw	3076	6	that	that	IN
cord-001835-0s7ok4uw	3076	7	distinct	distinct	JJ
cord-001835-0s7ok4uw	3076	8	selective	selective	JJ
cord-001835-0s7ok4uw	3076	9	pressure	pressure	NN
cord-001835-0s7ok4uw	3076	10	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	3076	11	acted	act	VBD
cord-001835-0s7ok4uw	3076	12	on	on	IN
cord-001835-0s7ok4uw	3076	13	metalloprotease	metalloprotease	NNP
cord-001835-0s7ok4uw	3076	14	structure	structure	NN
cord-001835-0s7ok4uw	3076	15	and	and	CC
cord-001835-0s7ok4uw	3076	16	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3076	17	through	through	IN
cord-001835-0s7ok4uw	3076	18	the	the	DT
cord-001835-0s7ok4uw	3076	19	course	course	NN
cord-001835-0s7ok4uw	3076	20	of	of	IN
cord-001835-0s7ok4uw	3076	21	evolution	evolution	NN
cord-001835-0s7ok4uw	3076	22	.	.	.
cord-001835-0s7ok4uw	3077	1	This	this	DT
cord-001835-0s7ok4uw	3077	2	work	work	NN
cord-001835-0s7ok4uw	3077	3	shows	show	VBZ
cord-001835-0s7ok4uw	3077	4	how	how	WRB
cord-001835-0s7ok4uw	3077	5	new	new	JJ
cord-001835-0s7ok4uw	3077	6	insights	insight	NNS
cord-001835-0s7ok4uw	3077	7	on	on	IN
cord-001835-0s7ok4uw	3077	8	metalloprotease	metalloprotease	NNP
cord-001835-0s7ok4uw	3077	9	function	function	NN
cord-001835-0s7ok4uw	3077	10	and	and	CC
cord-001835-0s7ok4uw	3077	11	evolution	evolution	NN
cord-001835-0s7ok4uw	3077	12	can	can	MD
cord-001835-0s7ok4uw	3077	13	be	be	VB
cord-001835-0s7ok4uw	3077	14	assessed	assess	VBN
cord-001835-0s7ok4uw	3077	15	with	with	IN
cord-001835-0s7ok4uw	3077	16	comparison	comparison	NN
cord-001835-0s7ok4uw	3077	17	schemes	scheme	NNS
cord-001835-0s7ok4uw	3077	18	that	that	WDT
cord-001835-0s7ok4uw	3077	19	incorporate	incorporate	VBP
cord-001835-0s7ok4uw	3077	20	additional	additional	JJ
cord-001835-0s7ok4uw	3077	21	information	information	NN
cord-001835-0s7ok4uw	3077	22	of	of	IN
cord-001835-0s7ok4uw	3077	23	protein	protein	NN
cord-001835-0s7ok4uw	3077	24	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3077	25	.	.	.
cord-001835-0s7ok4uw	3077	26	 	 	_SP
cord-001835-0s7ok4uw	3078	1	Glucokinase	Glucokinase	NNP
cord-001835-0s7ok4uw	3078	2	from	from	IN
cord-001835-0s7ok4uw	3078	3	Antarctic	Antarctic	NNP
cord-001835-0s7ok4uw	3078	4	psychrotroph	psychrotroph	NN
cord-001835-0s7ok4uw	3078	5	Pseudoalteromonas	Pseudoalteromonas	NNP
cord-001835-0s7ok4uw	3078	6	sp	sp	NN
cord-001835-0s7ok4uw	3078	7	.	.	.
cord-001835-0s7ok4uw	3079	1	AS-131	AS-131	NNP
cord-001835-0s7ok4uw	3079	2	(	(	-LRB-
cord-001835-0s7ok4uw	3079	3	PsGK	PsGK	NNP
cord-001835-0s7ok4uw	3079	4	)	)	-RRB-
cord-001835-0s7ok4uw	3079	5	has	have	VBZ
cord-001835-0s7ok4uw	3079	6	a	a	DT
cord-001835-0s7ok4uw	3079	7	higher	high	JJR
cord-001835-0s7ok4uw	3079	8	specific	specific	JJ
cord-001835-0s7ok4uw	3079	9	activity	activity	NN
cord-001835-0s7ok4uw	3079	10	at	at	IN
cord-001835-0s7ok4uw	3079	11	low	low	JJ
cord-001835-0s7ok4uw	3079	12	temperatures	temperature	NNS
cord-001835-0s7ok4uw	3079	13	and	and	CC
cord-001835-0s7ok4uw	3079	14	a	a	DT
cord-001835-0s7ok4uw	3079	15	higher	high	JJR
cord-001835-0s7ok4uw	3079	16	thermal	thermal	JJ
cord-001835-0s7ok4uw	3079	17	stability	stability	NN
cord-001835-0s7ok4uw	3079	18	than	than	IN
cord-001835-0s7ok4uw	3079	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3079	20	mesophilic	mesophilic	JJ
cord-001835-0s7ok4uw	3079	21	counterpart	counterpart	NN
cord-001835-0s7ok4uw	3079	22	from	from	IN
cord-001835-0s7ok4uw	3079	23	E.	E.	NNP
cord-001835-0s7ok4uw	3079	24	coli	coli	NNS
cord-001835-0s7ok4uw	3079	25	(	(	-LRB-
cord-001835-0s7ok4uw	3079	26	EcGK	EcGK	NNP
cord-001835-0s7ok4uw	3079	27	)	)	-RRB-
cord-001835-0s7ok4uw	3079	28	.	.	.
cord-001835-0s7ok4uw	3080	1	In	in	IN
cord-001835-0s7ok4uw	3080	2	order	order	NN
cord-001835-0s7ok4uw	3080	3	to	to	TO
cord-001835-0s7ok4uw	3080	4	elucidate	elucidate	VB
cord-001835-0s7ok4uw	3080	5	the	the	DT
cord-001835-0s7ok4uw	3080	6	structural	structural	JJ
cord-001835-0s7ok4uw	3080	7	basis	basis	NN
cord-001835-0s7ok4uw	3080	8	for	for	IN
cord-001835-0s7ok4uw	3080	9	cold	cold	JJ
cord-001835-0s7ok4uw	3080	10	-	-	HYPH
cord-001835-0s7ok4uw	3080	11	adaptation	adaptation	NN
cord-001835-0s7ok4uw	3080	12	and	and	CC
cord-001835-0s7ok4uw	3080	13	thermal	thermal	JJ
cord-001835-0s7ok4uw	3080	14	stabilization	stabilization	NN
cord-001835-0s7ok4uw	3080	15	of	of	IN
cord-001835-0s7ok4uw	3080	16	PsGK	PsGK	NNP
cord-001835-0s7ok4uw	3080	17	,	,	,
cord-001835-0s7ok4uw	3080	18	we	-PRON-	PRP
cord-001835-0s7ok4uw	3080	19	have	have	VBP
cord-001835-0s7ok4uw	3080	20	determined	determine	VBN
cord-001835-0s7ok4uw	3080	21	the	the	DT
cord-001835-0s7ok4uw	3080	22	crystal	crystal	JJ
cord-001835-0s7ok4uw	3080	23	structure	structure	NN
cord-001835-0s7ok4uw	3080	24	of	of	IN
cord-001835-0s7ok4uw	3080	25	PsGK	PsGK	NNP
cord-001835-0s7ok4uw	3080	26	at	at	IN
cord-001835-0s7ok4uw	3080	27	1.69	1.69	CD
cord-001835-0s7ok4uw	3080	28	Å	å	NN
cord-001835-0s7ok4uw	3080	29	and	and	CC
cord-001835-0s7ok4uw	3080	30	compared	compare	VBD
cord-001835-0s7ok4uw	3080	31	it	-PRON-	PRP
cord-001835-0s7ok4uw	3080	32	with	with	IN
cord-001835-0s7ok4uw	3080	33	the	the	DT
cord-001835-0s7ok4uw	3080	34	EcGK	EcGK	NNP
cord-001835-0s7ok4uw	3080	35	structure	structure	NN
cord-001835-0s7ok4uw	3080	36	.	.	.
cord-001835-0s7ok4uw	3081	1	PsGK	PsGK	NNP
cord-001835-0s7ok4uw	3081	2	is	be	VBZ
cord-001835-0s7ok4uw	3081	3	a	a	DT
cord-001835-0s7ok4uw	3081	4	homodimer	homodimer	NN
cord-001835-0s7ok4uw	3081	5	of	of	IN
cord-001835-0s7ok4uw	3081	6	the	the	DT
cord-001835-0s7ok4uw	3081	7	subunit	subunit	NN
cord-001835-0s7ok4uw	3081	8	of	of	IN
cord-001835-0s7ok4uw	3081	9	328	328	CD
cord-001835-0s7ok4uw	3081	10	amino	amino	NN
cord-001835-0s7ok4uw	3081	11	acid	acid	NN
cord-001835-0s7ok4uw	3081	12	residues	residue	NNS
cord-001835-0s7ok4uw	3081	13	.	.	.
cord-001835-0s7ok4uw	3082	1	Each	each	DT
cord-001835-0s7ok4uw	3082	2	subunit	subunit	NN
cord-001835-0s7ok4uw	3082	3	consists	consist	VBZ
cord-001835-0s7ok4uw	3082	4	of	of	IN
cord-001835-0s7ok4uw	3082	5	two	two	CD
cord-001835-0s7ok4uw	3082	6	domains	domain	NNS
cord-001835-0s7ok4uw	3082	7	,	,	,
cord-001835-0s7ok4uw	3082	8	a	a	DT
cord-001835-0s7ok4uw	3082	9	small	small	JJ
cord-001835-0s7ok4uw	3082	10	a	a	DT
cord-001835-0s7ok4uw	3082	11	/	/	SYM
cord-001835-0s7ok4uw	3082	12	b	b	NN
cord-001835-0s7ok4uw	3082	13	domain	domain	NN
cord-001835-0s7ok4uw	3082	14	(	(	-LRB-
cord-001835-0s7ok4uw	3082	15	residues	residue	NNS
cord-001835-0s7ok4uw	3082	16	7	7	CD
cord-001835-0s7ok4uw	3082	17	-	-	SYM
cord-001835-0s7ok4uw	3082	18	125	125	CD
cord-001835-0s7ok4uw	3082	19	and	and	CC
cord-001835-0s7ok4uw	3082	20	314	314	CD
cord-001835-0s7ok4uw	3082	21	-	-	SYM
cord-001835-0s7ok4uw	3082	22	328	328	CD
cord-001835-0s7ok4uw	3082	23	)	)	-RRB-
cord-001835-0s7ok4uw	3082	24	and	and	CC
cord-001835-0s7ok4uw	3082	25	a	a	DT
cord-001835-0s7ok4uw	3082	26	large	large	JJ
cord-001835-0s7ok4uw	3082	27	a	a	DT
cord-001835-0s7ok4uw	3082	28	1	1	CD
cord-001835-0s7ok4uw	3082	29	b	b	NN
cord-001835-0s7ok4uw	3082	30	domain	domain	NN
cord-001835-0s7ok4uw	3082	31	(	(	-LRB-
cord-001835-0s7ok4uw	3082	32	residues	residue	NNS
cord-001835-0s7ok4uw	3082	33	126	126	CD
cord-001835-0s7ok4uw	3082	34	-	-	HYPH
cord-001835-0s7ok4uw	3082	35	313	313	CD
cord-001835-0s7ok4uw	3082	36	)	)	-RRB-
cord-001835-0s7ok4uw	3082	37	.	.	.
cord-001835-0s7ok4uw	3083	1	The	the	DT
cord-001835-0s7ok4uw	3083	2	active	active	JJ
cord-001835-0s7ok4uw	3083	3	site	site	NN
cord-001835-0s7ok4uw	3083	4	is	be	VBZ
cord-001835-0s7ok4uw	3083	5	located	locate	VBN
cord-001835-0s7ok4uw	3083	6	in	in	IN
cord-001835-0s7ok4uw	3083	7	a	a	DT
cord-001835-0s7ok4uw	3083	8	cleft	cleft	NN
cord-001835-0s7ok4uw	3083	9	formed	form	VBN
cord-001835-0s7ok4uw	3083	10	between	between	IN
cord-001835-0s7ok4uw	3083	11	the	the	DT
cord-001835-0s7ok4uw	3083	12	two	two	CD
cord-001835-0s7ok4uw	3083	13	domains	domain	NNS
cord-001835-0s7ok4uw	3083	14	.	.	.
cord-001835-0s7ok4uw	3084	1	The	the	DT
cord-001835-0s7ok4uw	3084	2	identity	identity	NN
cord-001835-0s7ok4uw	3084	3	of	of	IN
cord-001835-0s7ok4uw	3084	4	amino	amino	NN
cord-001835-0s7ok4uw	3084	5	acid	acid	NN
cord-001835-0s7ok4uw	3084	6	sequence	sequence	NN
cord-001835-0s7ok4uw	3084	7	between	between	IN
cord-001835-0s7ok4uw	3084	8	PsGK	PsGK	NNP
cord-001835-0s7ok4uw	3084	9	and	and	CC
cord-001835-0s7ok4uw	3084	10	EcGK	EcGK	NNP
cord-001835-0s7ok4uw	3084	11	was	be	VBD
cord-001835-0s7ok4uw	3084	12	36	36	CD
cord-001835-0s7ok4uw	3084	13	%	%	NN
cord-001835-0s7ok4uw	3084	14	,	,	,
cord-001835-0s7ok4uw	3084	15	but	but	CC
cord-001835-0s7ok4uw	3084	16	three	three	CD
cord-001835-0s7ok4uw	3084	17	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	3084	18	structures	structure	NNS
cord-001835-0s7ok4uw	3084	19	of	of	IN
cord-001835-0s7ok4uw	3084	20	them	-PRON-	PRP
cord-001835-0s7ok4uw	3084	21	are	be	VBP
cord-001835-0s7ok4uw	3084	22	very	very	RB
cord-001835-0s7ok4uw	3084	23	similar	similar	JJ
cord-001835-0s7ok4uw	3084	24	to	to	IN
cord-001835-0s7ok4uw	3084	25	each	each	DT
cord-001835-0s7ok4uw	3084	26	other	other	JJ
cord-001835-0s7ok4uw	3084	27	,	,	,
cord-001835-0s7ok4uw	3084	28	having	have	VBG
cord-001835-0s7ok4uw	3084	29	the	the	DT
cord-001835-0s7ok4uw	3084	30	conserved	conserve	VBN
cord-001835-0s7ok4uw	3084	31	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3084	32	residues	residue	NNS
cord-001835-0s7ok4uw	3084	33	and	and	CC
cord-001835-0s7ok4uw	3084	34	substrate	substrate	NN
cord-001835-0s7ok4uw	3084	35	-	-	HYPH
cord-001835-0s7ok4uw	3084	36	binding	bind	VBG
cord-001835-0s7ok4uw	3084	37	residues	residue	NNS
cord-001835-0s7ok4uw	3084	38	.	.	.
cord-001835-0s7ok4uw	3085	1	The	the	DT
cord-001835-0s7ok4uw	3085	2	analysis	analysis	NN
cord-001835-0s7ok4uw	3085	3	of	of	IN
cord-001835-0s7ok4uw	3085	4	the	the	DT
cord-001835-0s7ok4uw	3085	5	mainchain	mainchain	NNP
cord-001835-0s7ok4uw	3085	6	temperature	temperature	NN
cord-001835-0s7ok4uw	3085	7	factors	factor	NNS
cord-001835-0s7ok4uw	3085	8	revealed	reveal	VBD
cord-001835-0s7ok4uw	3085	9	that	that	IN
cord-001835-0s7ok4uw	3085	10	the	the	DT
cord-001835-0s7ok4uw	3085	11	regions	region	NNS
cord-001835-0s7ok4uw	3085	12	of	of	IN
cord-001835-0s7ok4uw	3085	13	small	small	JJ
cord-001835-0s7ok4uw	3085	14	domain	domain	NN
cord-001835-0s7ok4uw	3085	15	and	and	CC
cord-001835-0s7ok4uw	3085	16	the	the	DT
cord-001835-0s7ok4uw	3085	17	hinge	hinge	NN
cord-001835-0s7ok4uw	3085	18	region	region	NN
cord-001835-0s7ok4uw	3085	19	connecting	connect	VBG
cord-001835-0s7ok4uw	3085	20	two	two	CD
cord-001835-0s7ok4uw	3085	21	domains	domain	NNS
cord-001835-0s7ok4uw	3085	22	of	of	IN
cord-001835-0s7ok4uw	3085	23	PsGK	PsGK	NNP
cord-001835-0s7ok4uw	3085	24	showed	show	VBD
cord-001835-0s7ok4uw	3085	25	higher	high	JJR
cord-001835-0s7ok4uw	3085	26	temperature	temperature	NN
cord-001835-0s7ok4uw	3085	27	factors	factor	NNS
cord-001835-0s7ok4uw	3085	28	with	with	IN
cord-001835-0s7ok4uw	3085	29	a	a	DT
cord-001835-0s7ok4uw	3085	30	lower	low	JJR
cord-001835-0s7ok4uw	3085	31	number	number	NN
cord-001835-0s7ok4uw	3085	32	of	of	IN
cord-001835-0s7ok4uw	3085	33	intramolecular	intramolecular	JJ
cord-001835-0s7ok4uw	3085	34	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3085	35	bonds	bond	NNS
cord-001835-0s7ok4uw	3085	36	and	and	CC
cord-001835-0s7ok4uw	3085	37	ionic	ionic	JJ
cord-001835-0s7ok4uw	3085	38	interactions	interaction	NNS
cord-001835-0s7ok4uw	3085	39	than	than	IN
cord-001835-0s7ok4uw	3085	40	the	the	DT
cord-001835-0s7ok4uw	3085	41	corresponding	correspond	VBG
cord-001835-0s7ok4uw	3085	42	regions	region	NNS
cord-001835-0s7ok4uw	3085	43	of	of	IN
cord-001835-0s7ok4uw	3085	44	EcGK	EcGK	NNP
cord-001835-0s7ok4uw	3085	45	.	.	.
cord-001835-0s7ok4uw	3086	1	However	however	RB
cord-001835-0s7ok4uw	3086	2	,	,	,
cord-001835-0s7ok4uw	3086	3	the	the	DT
cord-001835-0s7ok4uw	3086	4	large	large	JJ
cord-001835-0s7ok4uw	3086	5	domain	domain	NN
cord-001835-0s7ok4uw	3086	6	regions	region	NNS
cord-001835-0s7ok4uw	3086	7	of	of	IN
cord-001835-0s7ok4uw	3086	8	PsGK	PsGK	NNP
cord-001835-0s7ok4uw	3086	9	showed	show	VBD
cord-001835-0s7ok4uw	3086	10	lower	low	JJR
cord-001835-0s7ok4uw	3086	11	temperature	temperature	NN
cord-001835-0s7ok4uw	3086	12	factors	factor	NNS
cord-001835-0s7ok4uw	3086	13	with	with	IN
cord-001835-0s7ok4uw	3086	14	a	a	DT
cord-001835-0s7ok4uw	3086	15	higher	high	JJR
cord-001835-0s7ok4uw	3086	16	number	number	NN
cord-001835-0s7ok4uw	3086	17	of	of	IN
cord-001835-0s7ok4uw	3086	18	intramolecular	intramolecular	JJ
cord-001835-0s7ok4uw	3086	19	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3086	20	bonds	bond	NNS
cord-001835-0s7ok4uw	3086	21	than	than	IN
cord-001835-0s7ok4uw	3086	22	EcGK	EcGK	NNP
cord-001835-0s7ok4uw	3086	23	.	.	.
cord-001835-0s7ok4uw	3087	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	3087	2	,	,	,
cord-001835-0s7ok4uw	3087	3	the	the	DT
cord-001835-0s7ok4uw	3087	4	atomic	atomic	JJ
cord-001835-0s7ok4uw	3087	5	temperature	temperature	NN
cord-001835-0s7ok4uw	3087	6	factors	factor	NNS
cord-001835-0s7ok4uw	3087	7	of	of	IN
cord-001835-0s7ok4uw	3087	8	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3087	9	Asp112	Asp112	NNS
cord-001835-0s7ok4uw	3087	10	on	on	IN
cord-001835-0s7ok4uw	3087	11	the	the	DT
cord-001835-0s7ok4uw	3087	12	small	small	JJ
cord-001835-0s7ok4uw	3087	13	domain	domain	NN
cord-001835-0s7ok4uw	3087	14	were	be	VBD
cord-001835-0s7ok4uw	3087	15	higher	high	JJR
cord-001835-0s7ok4uw	3087	16	,	,	,
cord-001835-0s7ok4uw	3087	17	but	but	CC
cord-001835-0s7ok4uw	3087	18	those	those	DT
cord-001835-0s7ok4uw	3087	19	of	of	IN
cord-001835-0s7ok4uw	3087	20	glucose	glucose	NN
cord-001835-0s7ok4uw	3087	21	-	-	HYPH
cord-001835-0s7ok4uw	3087	22	binding	bind	VBG
cord-001835-0s7ok4uw	3087	23	Glu169	Glu169	NNS
cord-001835-0s7ok4uw	3087	24	,	,	,
cord-001835-0s7ok4uw	3087	25	His172	his172	CD
cord-001835-0s7ok4uw	3087	26	,	,	,
cord-001835-0s7ok4uw	3087	27	and	and	CC
cord-001835-0s7ok4uw	3087	28	Glu199	glu199	CD
cord-001835-0s7ok4uw	3087	29	on	on	IN
cord-001835-0s7ok4uw	3087	30	the	the	DT
cord-001835-0s7ok4uw	3087	31	large	large	JJ
cord-001835-0s7ok4uw	3087	32	domain	domain	NN
cord-001835-0s7ok4uw	3087	33	were	be	VBD
cord-001835-0s7ok4uw	3087	34	lower	low	JJR
cord-001835-0s7ok4uw	3087	35	than	than	IN
cord-001835-0s7ok4uw	3087	36	EcGK	EcGK	NNP
cord-001835-0s7ok4uw	3087	37	.	.	.
cord-001835-0s7ok4uw	3088	1	These	these	DT
cord-001835-0s7ok4uw	3088	2	results	result	NNS
cord-001835-0s7ok4uw	3088	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	3088	4	that	that	IN
cord-001835-0s7ok4uw	3088	5	highly	highly	RB
cord-001835-0s7ok4uw	3088	6	flexible	flexible	JJ
cord-001835-0s7ok4uw	3088	7	hinge	hinge	NN
cord-001835-0s7ok4uw	3088	8	region	region	NN
cord-001835-0s7ok4uw	3088	9	and	and	CC
cord-001835-0s7ok4uw	3088	10	the	the	DT
cord-001835-0s7ok4uw	3088	11	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3088	12	residue	residue	NN
cord-001835-0s7ok4uw	3088	13	on	on	IN
cord-001835-0s7ok4uw	3088	14	the	the	DT
cord-001835-0s7ok4uw	3088	15	small	small	JJ
cord-001835-0s7ok4uw	3088	16	domain	domain	NN
cord-001835-0s7ok4uw	3088	17	of	of	IN
cord-001835-0s7ok4uw	3088	18	PsGK	PsGK	NNP
cord-001835-0s7ok4uw	3088	19	may	may	MD
cord-001835-0s7ok4uw	3088	20	contribute	contribute	VB
cord-001835-0s7ok4uw	3088	21	to	to	IN
cord-001835-0s7ok4uw	3088	22	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3088	23	cold	cold	JJ
cord-001835-0s7ok4uw	3088	24	-	-	HYPH
cord-001835-0s7ok4uw	3088	25	adaptation	adaptation	NN
cord-001835-0s7ok4uw	3088	26	,	,	,
cord-001835-0s7ok4uw	3088	27	namely	namely	RB
cord-001835-0s7ok4uw	3088	28	higher	high	JJR
cord-001835-0s7ok4uw	3088	29	activity	activity	NN
cord-001835-0s7ok4uw	3088	30	at	at	IN
cord-001835-0s7ok4uw	3088	31	low	low	JJ
cord-001835-0s7ok4uw	3088	32	temperatures	temperature	NNS
cord-001835-0s7ok4uw	3088	33	,	,	,
cord-001835-0s7ok4uw	3088	34	whereas	whereas	IN
cord-001835-0s7ok4uw	3088	35	a	a	DT
cord-001835-0s7ok4uw	3088	36	more	more	RBR
cord-001835-0s7ok4uw	3088	37	rigid	rigid	JJ
cord-001835-0s7ok4uw	3088	38	structure	structure	NN
cord-001835-0s7ok4uw	3088	39	of	of	IN
cord-001835-0s7ok4uw	3088	40	the	the	DT
cord-001835-0s7ok4uw	3088	41	large	large	JJ
cord-001835-0s7ok4uw	3088	42	domain	domain	NN
cord-001835-0s7ok4uw	3088	43	of	of	IN
cord-001835-0s7ok4uw	3088	44	PsGK	PsGK	NNP
cord-001835-0s7ok4uw	3088	45	stabilizes	stabilize	VBZ
cord-001835-0s7ok4uw	3088	46	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3088	47	overall	overall	JJ
cord-001835-0s7ok4uw	3088	48	structure	structure	NN
cord-001835-0s7ok4uw	3088	49	more	more	RBR
cord-001835-0s7ok4uw	3088	50	strongly	strongly	RB
cord-001835-0s7ok4uw	3088	51	than	than	IN
cord-001835-0s7ok4uw	3088	52	EcGK	EcGK	NNP
cord-001835-0s7ok4uw	3088	53	.	.	.
cord-001835-0s7ok4uw	3089	1	Nowadays	nowadays	RB
cord-001835-0s7ok4uw	3089	2	non	non	JJ
cord-001835-0s7ok4uw	3089	3	-	-	JJ
cord-001835-0s7ok4uw	3089	4	waste	waste	JJ
cord-001835-0s7ok4uw	3089	5	technologies	technology	NNS
cord-001835-0s7ok4uw	3089	6	in	in	IN
cord-001835-0s7ok4uw	3089	7	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3089	8	chemistry	chemistry	NN
cord-001835-0s7ok4uw	3089	9	become	become	VBP
cord-001835-0s7ok4uw	3089	10	more	more	RBR
cord-001835-0s7ok4uw	3089	11	and	and	CC
cord-001835-0s7ok4uw	3089	12	more	more	RBR
cord-001835-0s7ok4uw	3089	13	popular	popular	JJ
cord-001835-0s7ok4uw	3089	14	.	.	.
cord-001835-0s7ok4uw	3090	1	Such	such	JJ
cord-001835-0s7ok4uw	3090	2	processes	process	NNS
cord-001835-0s7ok4uw	3090	3	are	be	VBP
cord-001835-0s7ok4uw	3090	4	often	often	RB
cord-001835-0s7ok4uw	3090	5	carried	carry	VBN
cord-001835-0s7ok4uw	3090	6	out	out	RP
cord-001835-0s7ok4uw	3090	7	using	use	VBG
cord-001835-0s7ok4uw	3090	8	different	different	JJ
cord-001835-0s7ok4uw	3090	9	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3090	10	.	.	.
cord-001835-0s7ok4uw	3091	1	Dehydrogenases	dehydrogenase	NNS
cord-001835-0s7ok4uw	3091	2	represent	represent	VBP
cord-001835-0s7ok4uw	3091	3	the	the	DT
cord-001835-0s7ok4uw	3091	4	large	large	JJ
cord-001835-0s7ok4uw	3091	5	group	group	NN
cord-001835-0s7ok4uw	3091	6	of	of	IN
cord-001835-0s7ok4uw	3091	7	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3091	8	,	,	,
cord-001835-0s7ok4uw	3091	9	which	which	WDT
cord-001835-0s7ok4uw	3091	10	are	be	VBP
cord-001835-0s7ok4uw	3091	11	widely	widely	RB
cord-001835-0s7ok4uw	3091	12	used	use	VBN
cord-001835-0s7ok4uw	3091	13	in	in	IN
cord-001835-0s7ok4uw	3091	14	synthesis	synthesis	NN
cord-001835-0s7ok4uw	3091	15	of	of	IN
cord-001835-0s7ok4uw	3091	16	chiral	chiral	JJ
cord-001835-0s7ok4uw	3091	17	compounds	compound	NNS
cord-001835-0s7ok4uw	3091	18	and	and	CC
cord-001835-0s7ok4uw	3091	19	other	other	JJ
cord-001835-0s7ok4uw	3091	20	useful	useful	JJ
cord-001835-0s7ok4uw	3091	21	molecules	molecule	NNS
cord-001835-0s7ok4uw	3091	22	.	.	.
cord-001835-0s7ok4uw	3092	1	Such	such	JJ
cord-001835-0s7ok4uw	3092	2	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3092	3	need	need	VBP
cord-001835-0s7ok4uw	3092	4	NADH	NADH	NNP
cord-001835-0s7ok4uw	3092	5	or	or	CC
cord-001835-0s7ok4uw	3092	6	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	3092	7	as	as	IN
cord-001835-0s7ok4uw	3092	8	a	a	DT
cord-001835-0s7ok4uw	3092	9	cofactor	cofactor	NN
cord-001835-0s7ok4uw	3092	10	and	and	CC
cord-001835-0s7ok4uw	3092	11	due	due	JJ
cord-001835-0s7ok4uw	3092	12	to	to	IN
cord-001835-0s7ok4uw	3092	13	high	high	JJ
cord-001835-0s7ok4uw	3092	14	cost	cost	NN
cord-001835-0s7ok4uw	3092	15	of	of	IN
cord-001835-0s7ok4uw	3092	16	reduced	reduce	VBN
cord-001835-0s7ok4uw	3092	17	coenzymes	coenzyme	NNS
cord-001835-0s7ok4uw	3092	18	a	a	DT
cord-001835-0s7ok4uw	3092	19	cofactor	cofactor	NN
cord-001835-0s7ok4uw	3092	20	regeneration	regeneration	NN
cord-001835-0s7ok4uw	3092	21	system	system	NN
cord-001835-0s7ok4uw	3092	22	is	be	VBZ
cord-001835-0s7ok4uw	3092	23	an	an	DT
cord-001835-0s7ok4uw	3092	24	obligate	obligate	JJ
cord-001835-0s7ok4uw	3092	25	part	part	NN
cord-001835-0s7ok4uw	3092	26	in	in	IN
cord-001835-0s7ok4uw	3092	27	such	such	JJ
cord-001835-0s7ok4uw	3092	28	kind	kind	NN
cord-001835-0s7ok4uw	3092	29	of	of	IN
cord-001835-0s7ok4uw	3092	30	processes	process	NNS
cord-001835-0s7ok4uw	3092	31	.	.	.
cord-001835-0s7ok4uw	3093	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3093	2	was	be	VBD
cord-001835-0s7ok4uw	3093	3	shown	show	VBN
cord-001835-0s7ok4uw	3093	4	that	that	IN
cord-001835-0s7ok4uw	3093	5	formate	formate	NN
cord-001835-0s7ok4uw	3093	6	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	3093	7	(	(	-LRB-
cord-001835-0s7ok4uw	3093	8	FDH	FDH	NNP
cord-001835-0s7ok4uw	3093	9	,	,	,
cord-001835-0s7ok4uw	3093	10	EC	EC	NNP
cord-001835-0s7ok4uw	3093	11	1.2.1.2	1.2.1.2	CD
cord-001835-0s7ok4uw	3093	12	.	.	.
cord-001835-0s7ok4uw	3093	13	)	)	-RRB-
cord-001835-0s7ok4uw	3093	14	is	be	VBZ
cord-001835-0s7ok4uw	3093	15	one	one	CD
cord-001835-0s7ok4uw	3093	16	of	of	IN
cord-001835-0s7ok4uw	3093	17	the	the	DT
cord-001835-0s7ok4uw	3093	18	best	good	JJS
cord-001835-0s7ok4uw	3093	19	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3093	20	for	for	IN
cord-001835-0s7ok4uw	3093	21	NAD(P)H	NAD(P)H	NNP
cord-001835-0s7ok4uw	3093	22	regeneration	regeneration	NN
cord-001835-0s7ok4uw	3093	23	.	.	.
cord-001835-0s7ok4uw	3094	1	FDH	FDH	NNP
cord-001835-0s7ok4uw	3094	2	catalyses	catalyse	VBZ
cord-001835-0s7ok4uw	3094	3	the	the	DT
cord-001835-0s7ok4uw	3094	4	reaction	reaction	NN
cord-001835-0s7ok4uw	3094	5	of	of	IN
cord-001835-0s7ok4uw	3094	6	formate	formate	NN
cord-001835-0s7ok4uw	3094	7	oxidation	oxidation	NN
cord-001835-0s7ok4uw	3094	8	to	to	IN
cord-001835-0s7ok4uw	3094	9	carbon	carbon	NN
cord-001835-0s7ok4uw	3094	10	dioxide	dioxide	NN
cord-001835-0s7ok4uw	3094	11	coupled	couple	VBN
cord-001835-0s7ok4uw	3094	12	with	with	IN
cord-001835-0s7ok4uw	3094	13	reduction	reduction	NN
cord-001835-0s7ok4uw	3094	14	of	of	IN
cord-001835-0s7ok4uw	3094	15	NAD(P)1	nad(p)1	NN
cord-001835-0s7ok4uw	3094	16	to	to	IN
cord-001835-0s7ok4uw	3094	17	NAD(P)H.	nad(p)h.	NN
cord-001835-0s7ok4uw	3095	1	The	the	DT
cord-001835-0s7ok4uw	3095	2	main	main	JJ
cord-001835-0s7ok4uw	3095	3	advantages	advantage	NNS
cord-001835-0s7ok4uw	3095	4	of	of	IN
cord-001835-0s7ok4uw	3095	5	FDH	FDH	NNP
cord-001835-0s7ok4uw	3095	6	are	be	VBP
cord-001835-0s7ok4uw	3095	7	the	the	DT
cord-001835-0s7ok4uw	3095	8	irreversibility	irreversibility	NN
cord-001835-0s7ok4uw	3095	9	of	of	IN
cord-001835-0s7ok4uw	3095	10	catalyzed	catalyzed	JJ
cord-001835-0s7ok4uw	3095	11	reaction	reaction	NN
cord-001835-0s7ok4uw	3095	12	,	,	,
cord-001835-0s7ok4uw	3095	13	low	low	JJ
cord-001835-0s7ok4uw	3095	14	price	price	NN
cord-001835-0s7ok4uw	3095	15	of	of	IN
cord-001835-0s7ok4uw	3095	16	formate	formate	NN
cord-001835-0s7ok4uw	3095	17	ion	ion	NN
cord-001835-0s7ok4uw	3095	18	and	and	CC
cord-001835-0s7ok4uw	3095	19	wide	wide	JJ
cord-001835-0s7ok4uw	3095	20	pH	pH	NNP
cord-001835-0s7ok4uw	3095	21	optimum	optimum	NN
cord-001835-0s7ok4uw	3095	22	of	of	IN
cord-001835-0s7ok4uw	3095	23	activity	activity	NN
cord-001835-0s7ok4uw	3095	24	.	.	.
cord-001835-0s7ok4uw	3096	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3096	2	laboratory	laboratory	NN
cord-001835-0s7ok4uw	3096	3	has	have	VBZ
cord-001835-0s7ok4uw	3096	4	the	the	DT
cord-001835-0s7ok4uw	3096	5	largest	large	JJS
cord-001835-0s7ok4uw	3096	6	collection	collection	NN
cord-001835-0s7ok4uw	3096	7	of	of	IN
cord-001835-0s7ok4uw	3096	8	formate	formate	NN
cord-001835-0s7ok4uw	3096	9	dehydrogenases	dehydrogenase	NNS
cord-001835-0s7ok4uw	3096	10	from	from	IN
cord-001835-0s7ok4uw	3096	11	different	different	JJ
cord-001835-0s7ok4uw	3096	12	sources	source	NNS
cord-001835-0s7ok4uw	3096	13	.	.	.
cord-001835-0s7ok4uw	3097	1	Many	many	JJ
cord-001835-0s7ok4uw	3097	2	FDH	FDH	NNP
cord-001835-0s7ok4uw	3097	3	genes	gene	NNS
cord-001835-0s7ok4uw	3097	4	from	from	IN
cord-001835-0s7ok4uw	3097	5	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	3097	6	,	,	,
cord-001835-0s7ok4uw	3097	7	yeasts	yeast	NNS
cord-001835-0s7ok4uw	3097	8	and	and	CC
cord-001835-0s7ok4uw	3097	9	plants	plant	NNS
cord-001835-0s7ok4uw	3097	10	were	be	VBD
cord-001835-0s7ok4uw	3097	11	cloned	clone	VBN
cord-001835-0s7ok4uw	3097	12	and	and	CC
cord-001835-0s7ok4uw	3097	13	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3097	14	were	be	VBD
cord-001835-0s7ok4uw	3097	15	expressed	express	VBN
cord-001835-0s7ok4uw	3097	16	in	in	IN
cord-001835-0s7ok4uw	3097	17	active	active	JJ
cord-001835-0s7ok4uw	3097	18	and	and	CC
cord-001835-0s7ok4uw	3097	19	soluble	soluble	JJ
cord-001835-0s7ok4uw	3097	20	forms	form	NNS
cord-001835-0s7ok4uw	3097	21	.	.	.
cord-001835-0s7ok4uw	3098	1	Mutant	mutant	JJ
cord-001835-0s7ok4uw	3098	2	formate	formate	NN
cord-001835-0s7ok4uw	3098	3	dehydrogenases	dehydrogenase	NNS
cord-001835-0s7ok4uw	3098	4	from	from	IN
cord-001835-0s7ok4uw	3098	5	bacterium	bacterium	NN
cord-001835-0s7ok4uw	3098	6	Pseudomonas	Pseudomonas	NNP
cord-001835-0s7ok4uw	3099	1	sp.101	sp.101	NNP
cord-001835-0s7ok4uw	3099	2	show	show	VB
cord-001835-0s7ok4uw	3099	3	the	the	DT
cord-001835-0s7ok4uw	3099	4	highest	high	JJS
cord-001835-0s7ok4uw	3099	5	thermal	thermal	JJ
cord-001835-0s7ok4uw	3099	6	stability	stability	NN
cord-001835-0s7ok4uw	3099	7	as	as	RB
cord-001835-0s7ok4uw	3099	8	well	well	RB
cord-001835-0s7ok4uw	3099	9	as	as	IN
cord-001835-0s7ok4uw	3099	10	activity	activity	NN
cord-001835-0s7ok4uw	3099	11	in	in	IN
cord-001835-0s7ok4uw	3099	12	comparison	comparison	NN
cord-001835-0s7ok4uw	3099	13	with	with	IN
cord-001835-0s7ok4uw	3099	14	other	other	JJ
cord-001835-0s7ok4uw	3099	15	reported	report	VBN
cord-001835-0s7ok4uw	3099	16	formate	formate	NN
cord-001835-0s7ok4uw	3099	17	dehydrogenases	dehydrogenase	NNS
cord-001835-0s7ok4uw	3099	18	.	.	.
cord-001835-0s7ok4uw	3100	1	Now	now	RB
cord-001835-0s7ok4uw	3100	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3100	3	have	have	VBP
cord-001835-0s7ok4uw	3100	4	focused	focus	VBN
cord-001835-0s7ok4uw	3100	5	on	on	IN
cord-001835-0s7ok4uw	3100	6	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	3100	7	genes	gene	NNS
cord-001835-0s7ok4uw	3100	8	.	.	.
cord-001835-0s7ok4uw	3101	1	The	the	DT
cord-001835-0s7ok4uw	3101	2	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	3101	3	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3101	4	from	from	IN
cord-001835-0s7ok4uw	3101	5	soya	soya	NN
cord-001835-0s7ok4uw	3101	6	Glycine	glycine	NN
cord-001835-0s7ok4uw	3101	7	max	max	NN
cord-001835-0s7ok4uw	3101	8	(	(	-LRB-
cord-001835-0s7ok4uw	3101	9	SoyFDH	SoyFDH	NNP
cord-001835-0s7ok4uw	3101	10	)	)	-RRB-
cord-001835-0s7ok4uw	3101	11	,	,	,
cord-001835-0s7ok4uw	3101	12	Arabidopsis	Arabidopsis	NNP
cord-001835-0s7ok4uw	3101	13	thaliana	thaliana	NN
cord-001835-0s7ok4uw	3101	14	(	(	-LRB-
cord-001835-0s7ok4uw	3101	15	AthFDH	athfdh	NN
cord-001835-0s7ok4uw	3101	16	)	)	-RRB-
cord-001835-0s7ok4uw	3101	17	,	,	,
cord-001835-0s7ok4uw	3101	18	moss	moss	NNP
cord-001835-0s7ok4uw	3101	19	Physcomitrella	Physcomitrella	NNP
cord-001835-0s7ok4uw	3101	20	patens	paten	NNS
cord-001835-0s7ok4uw	3101	21	(	(	-LRB-
cord-001835-0s7ok4uw	3101	22	PpaFDH	PpaFDH	NNP
cord-001835-0s7ok4uw	3101	23	)	)	-RRB-
cord-001835-0s7ok4uw	3101	24	and	and	CC
cord-001835-0s7ok4uw	3101	25	yeast	yeast	NN
cord-001835-0s7ok4uw	3101	26	Ogataea	Ogataea	NNP
cord-001835-0s7ok4uw	3101	27	parapolymorpha	parapolymorpha	NNP
cord-001835-0s7ok4uw	3101	28	(	(	-LRB-
cord-001835-0s7ok4uw	3101	29	OpaFDH	OpaFDH	NNP
cord-001835-0s7ok4uw	3101	30	)	)	-RRB-
cord-001835-0s7ok4uw	3101	31	were	be	VBD
cord-001835-0s7ok4uw	3101	32	obtained	obtain	VBN
cord-001835-0s7ok4uw	3101	33	by	by	IN
cord-001835-0s7ok4uw	3101	34	genetic	genetic	JJ
cord-001835-0s7ok4uw	3101	35	engineering	engineering	NN
cord-001835-0s7ok4uw	3101	36	methods	method	NNS
cord-001835-0s7ok4uw	3101	37	.	.	.
cord-001835-0s7ok4uw	3102	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3102	2	was	be	VBD
cord-001835-0s7ok4uw	3102	3	revealed	reveal	VBN
cord-001835-0s7ok4uw	3102	4	,	,	,
cord-001835-0s7ok4uw	3102	5	that	that	IN
cord-001835-0s7ok4uw	3102	6	SoyFDH	SoyFDH	NNP
cord-001835-0s7ok4uw	3102	7	has	have	VBZ
cord-001835-0s7ok4uw	3102	8	the	the	DT
cord-001835-0s7ok4uw	3102	9	best	good	JJS
cord-001835-0s7ok4uw	3102	10	Michaelis	Michaelis	NNP
cord-001835-0s7ok4uw	3102	11	constants	constant	NNS
cord-001835-0s7ok4uw	3102	12	among	among	IN
cord-001835-0s7ok4uw	3102	13	all	all	DT
cord-001835-0s7ok4uw	3102	14	known	know	VBN
cord-001835-0s7ok4uw	3102	15	FDHs	fdh	NNS
cord-001835-0s7ok4uw	3102	16	,	,	,
cord-001835-0s7ok4uw	3102	17	but	but	CC
cord-001835-0s7ok4uw	3102	18	it	-PRON-	PRP
cord-001835-0s7ok4uw	3102	19	's	be	VBZ
cord-001835-0s7ok4uw	3102	20	less	less	RBR
cord-001835-0s7ok4uw	3102	21	thermally	thermally	RB
cord-001835-0s7ok4uw	3102	22	stable	stable	JJ
cord-001835-0s7ok4uw	3102	23	compared	compare	VBN
cord-001835-0s7ok4uw	3102	24	to	to	IN
cord-001835-0s7ok4uw	3102	25	other	other	JJ
cord-001835-0s7ok4uw	3102	26	FDHs	fdh	NNS
cord-001835-0s7ok4uw	3102	27	.	.	.
cord-001835-0s7ok4uw	3103	1	New	new	JJ
cord-001835-0s7ok4uw	3103	2	mutant	mutant	JJ
cord-001835-0s7ok4uw	3103	3	forms	form	NNS
cord-001835-0s7ok4uw	3103	4	of	of	IN
cord-001835-0s7ok4uw	3103	5	SoyFDH	soyfdh	NN
cord-001835-0s7ok4uw	3103	6	with	with	IN
cord-001835-0s7ok4uw	3103	7	excellent	excellent	JJ
cord-001835-0s7ok4uw	3103	8	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3103	9	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	3103	10	and	and	CC
cord-001835-0s7ok4uw	3103	11	high	high	JJ
cord-001835-0s7ok4uw	3103	12	thermal	thermal	JJ
cord-001835-0s7ok4uw	3103	13	stability	stability	NN
cord-001835-0s7ok4uw	3103	14	were	be	VBD
cord-001835-0s7ok4uw	3103	15	obtained	obtain	VBN
cord-001835-0s7ok4uw	3103	16	by	by	IN
cord-001835-0s7ok4uw	3103	17	protein	protein	NN
cord-001835-0s7ok4uw	3103	18	engineering	engineering	NN
cord-001835-0s7ok4uw	3103	19	.	.	.
cord-001835-0s7ok4uw	3104	1	Other	other	JJ
cord-001835-0s7ok4uw	3104	2	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3104	3	(	(	-LRB-
cord-001835-0s7ok4uw	3104	4	AthFDH	athfdh	NN
cord-001835-0s7ok4uw	3104	5	,	,	,
cord-001835-0s7ok4uw	3104	6	PpaFDH	PpaFDH	NNP
cord-001835-0s7ok4uw	3104	7	and	and	CC
cord-001835-0s7ok4uw	3104	8	OpaFDH	OpaFDH	NNP
cord-001835-0s7ok4uw	3104	9	)	)	-RRB-
cord-001835-0s7ok4uw	3104	10	are	be	VBP
cord-001835-0s7ok4uw	3104	11	comparable	comparable	JJ
cord-001835-0s7ok4uw	3104	12	in	in	IN
cord-001835-0s7ok4uw	3104	13	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3104	14	stability	stability	NN
cord-001835-0s7ok4uw	3104	15	with	with	IN
cord-001835-0s7ok4uw	3104	16	majority	majority	NN
cord-001835-0s7ok4uw	3104	17	of	of	IN
cord-001835-0s7ok4uw	3104	18	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	3104	19	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3104	20	(	(	-LRB-
cord-001835-0s7ok4uw	3104	21	but	but	CC
cord-001835-0s7ok4uw	3104	22	not	not	RB
cord-001835-0s7ok4uw	3104	23	with	with	IN
cord-001835-0s7ok4uw	3104	24	PseFDH	PseFDH	NNP
cord-001835-0s7ok4uw	3104	25	)	)	-RRB-
cord-001835-0s7ok4uw	3104	26	,	,	,
cord-001835-0s7ok4uw	3104	27	so	so	IN
cord-001835-0s7ok4uw	3104	28	all	all	PDT
cord-001835-0s7ok4uw	3104	29	the	the	DT
cord-001835-0s7ok4uw	3104	30	new	new	JJ
cord-001835-0s7ok4uw	3104	31	obtained	obtain	VBN
cord-001835-0s7ok4uw	3104	32	FDHs	fdh	NNS
cord-001835-0s7ok4uw	3104	33	can	can	MD
cord-001835-0s7ok4uw	3104	34	be	be	VB
cord-001835-0s7ok4uw	3104	35	successfully	successfully	RB
cord-001835-0s7ok4uw	3104	36	used	use	VBN
cord-001835-0s7ok4uw	3104	37	for	for	IN
cord-001835-0s7ok4uw	3104	38	cofactor	cofactor	NN
cord-001835-0s7ok4uw	3104	39	regeneration	regeneration	NN
cord-001835-0s7ok4uw	3104	40	.	.	.
cord-001835-0s7ok4uw	3105	1	Marmara	Marmara	NNP
cord-001835-0s7ok4uw	3105	2	University	University	NNP
cord-001835-0s7ok4uw	3105	3	,	,	,
cord-001835-0s7ok4uw	3105	4	2	2	CD
cord-001835-0s7ok4uw	3105	5	Wellesley	Wellesley	NNP
cord-001835-0s7ok4uw	3105	6	College	College	NNP
cord-001835-0s7ok4uw	3105	7	,	,	,
cord-001835-0s7ok4uw	3105	8	3	3	CD
cord-001835-0s7ok4uw	3105	9	 	 	_SP
cord-001835-0s7ok4uw	3105	10	Antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	3105	11	are	be	VBP
cord-001835-0s7ok4uw	3105	12	essential	essential	JJ
cord-001835-0s7ok4uw	3105	13	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	3105	14	drugs	drug	NNS
cord-001835-0s7ok4uw	3105	15	widely	widely	RB
cord-001835-0s7ok4uw	3105	16	used	use	VBN
cord-001835-0s7ok4uw	3105	17	in	in	IN
cord-001835-0s7ok4uw	3105	18	the	the	DT
cord-001835-0s7ok4uw	3105	19	treatment	treatment	NN
cord-001835-0s7ok4uw	3105	20	of	of	IN
cord-001835-0s7ok4uw	3105	21	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	3105	22	infections	infection	NNS
cord-001835-0s7ok4uw	3105	23	.	.	.
cord-001835-0s7ok4uw	3106	1	Unfortunately	unfortunately	RB
cord-001835-0s7ok4uw	3106	2	,	,	,
cord-001835-0s7ok4uw	3106	3	misuse	misuse	NN
cord-001835-0s7ok4uw	3106	4	of	of	IN
cord-001835-0s7ok4uw	3106	5	these	these	DT
cord-001835-0s7ok4uw	3106	6	drugs	drug	NNS
cord-001835-0s7ok4uw	3106	7	resulted	result	VBD
cord-001835-0s7ok4uw	3106	8	in	in	IN
cord-001835-0s7ok4uw	3106	9	the	the	DT
cord-001835-0s7ok4uw	3106	10	development	development	NN
cord-001835-0s7ok4uw	3106	11	of	of	IN
cord-001835-0s7ok4uw	3106	12	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	3106	13	defense	defense	NN
cord-001835-0s7ok4uw	3106	14	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	3106	15	.	.	.
cord-001835-0s7ok4uw	3107	1	Blactamase	Blactamase	NNP
cord-001835-0s7ok4uw	3107	2	synthesis	synthesis	NN
cord-001835-0s7ok4uw	3107	3	is	be	VBZ
cord-001835-0s7ok4uw	3107	4	among	among	IN
cord-001835-0s7ok4uw	3107	5	these	these	DT
cord-001835-0s7ok4uw	3107	6	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	3107	7	that	that	WDT
cord-001835-0s7ok4uw	3107	8	renders	render	VBZ
cord-001835-0s7ok4uw	3107	9	b	b	NN
cord-001835-0s7ok4uw	3107	10	-	-	HYPH
cord-001835-0s7ok4uw	3107	11	lactam	lactam	NN
cord-001835-0s7ok4uw	3107	12	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	3107	13	ineffective	ineffective	JJ
cord-001835-0s7ok4uw	3107	14	.	.	.
cord-001835-0s7ok4uw	3108	1	Understanding	understand	VBG
cord-001835-0s7ok4uw	3108	2	the	the	DT
cord-001835-0s7ok4uw	3108	3	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	3108	4	behavior	behavior	NN
cord-001835-0s7ok4uw	3108	5	of	of	IN
cord-001835-0s7ok4uw	3108	6	this	this	DT
cord-001835-0s7ok4uw	3108	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3108	8	is	be	VBZ
cord-001835-0s7ok4uw	3108	9	an	an	DT
cord-001835-0s7ok4uw	3108	10	important	important	JJ
cord-001835-0s7ok4uw	3108	11	step	step	NN
cord-001835-0s7ok4uw	3108	12	in	in	IN
cord-001835-0s7ok4uw	3108	13	controlling	control	VBG
cord-001835-0s7ok4uw	3108	14	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3108	15	activity	activity	NN
cord-001835-0s7ok4uw	3108	16	.	.	.
cord-001835-0s7ok4uw	3109	1	In	in	IN
cord-001835-0s7ok4uw	3109	2	a	a	DT
cord-001835-0s7ok4uw	3109	3	former	former	JJ
cord-001835-0s7ok4uw	3109	4	study	study	NN
cord-001835-0s7ok4uw	3109	5	,	,	,
cord-001835-0s7ok4uw	3109	6	the	the	DT
cord-001835-0s7ok4uw	3109	7	importance	importance	NN
cord-001835-0s7ok4uw	3109	8	of	of	IN
cord-001835-0s7ok4uw	3109	9	highly	highly	RB
cord-001835-0s7ok4uw	3109	10	conserved	conserved	JJ
cord-001835-0s7ok4uw	3109	11	W229	w229	JJ
cord-001835-0s7ok4uw	3109	12	in	in	IN
cord-001835-0s7ok4uw	3109	13	modulating	modulate	VBG
cord-001835-0s7ok4uw	3109	14	the	the	DT
cord-001835-0s7ok4uw	3109	15	hinge	hinge	NN
cord-001835-0s7ok4uw	3109	16	type	type	NN
cord-001835-0s7ok4uw	3109	17	H10	H10	NNP
cord-001835-0s7ok4uw	3109	18	motion	motion	NN
cord-001835-0s7ok4uw	3109	19	was	be	VBD
cord-001835-0s7ok4uw	3109	20	reported	report	VBN
cord-001835-0s7ok4uw	3109	21	.	.	.
cord-001835-0s7ok4uw	3110	1	In	in	IN
cord-001835-0s7ok4uw	3110	2	the	the	DT
cord-001835-0s7ok4uw	3110	3	light	light	NN
cord-001835-0s7ok4uw	3110	4	of	of	IN
cord-001835-0s7ok4uw	3110	5	this	this	DT
cord-001835-0s7ok4uw	3110	6	information	information	NN
cord-001835-0s7ok4uw	3110	7	,	,	,
cord-001835-0s7ok4uw	3110	8	mutant	mutant	JJ
cord-001835-0s7ok4uw	3110	9	TEM-1	TEM-1	NNP
cord-001835-0s7ok4uw	3110	10	b	b	NN
cord-001835-0s7ok4uw	3110	11	-	-	HYPH
cord-001835-0s7ok4uw	3110	12	lactamase	lactamase	NN
cord-001835-0s7ok4uw	3110	13	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3110	14	with	with	IN
cord-001835-0s7ok4uw	3110	15	W229A	W229A	NNS
cord-001835-0s7ok4uw	3110	16	,	,	,
cord-001835-0s7ok4uw	3110	17	W229F	W229F	NNPS
cord-001835-0s7ok4uw	3110	18	and	and	CC
cord-001835-0s7ok4uw	3110	19	W229Y	w229y	JJ
cord-001835-0s7ok4uw	3110	20	substitutions	substitution	NNS
cord-001835-0s7ok4uw	3110	21	were	be	VBD
cord-001835-0s7ok4uw	3110	22	constructed	construct	VBN
cord-001835-0s7ok4uw	3110	23	.	.	.
cord-001835-0s7ok4uw	3111	1	Wild	wild	JJ
cord-001835-0s7ok4uw	3111	2	-	-	HYPH
cord-001835-0s7ok4uw	3111	3	type	type	NN
cord-001835-0s7ok4uw	3111	4	and	and	CC
cord-001835-0s7ok4uw	3111	5	mutant	mutant	JJ
cord-001835-0s7ok4uw	3111	6	TEM-1	TEM-1	NNP
cord-001835-0s7ok4uw	3111	7	b	b	NNP
cord-001835-0s7ok4uw	3111	8	-	-	HYPH
cord-001835-0s7ok4uw	3111	9	lactamases	lactamase	NNS
cord-001835-0s7ok4uw	3111	10	purified	purify	VBN
cord-001835-0s7ok4uw	3111	11	with	with	IN
cord-001835-0s7ok4uw	3111	12	Ni21affinity	ni21affinity	NN
cord-001835-0s7ok4uw	3111	13	chromatography	chromatography	NN
cord-001835-0s7ok4uw	3111	14	were	be	VBD
cord-001835-0s7ok4uw	3111	15	subjected	subject	VBN
cord-001835-0s7ok4uw	3111	16	to	to	IN
cord-001835-0s7ok4uw	3111	17	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3111	18	assay	assay	NN
cord-001835-0s7ok4uw	3111	19	using	use	VBG
cord-001835-0s7ok4uw	3111	20	CENTA	CENTA	NNP
cord-001835-0s7ok4uw	3111	21	as	as	IN
cord-001835-0s7ok4uw	3111	22	the	the	DT
cord-001835-0s7ok4uw	3111	23	substrate	substrate	NN
cord-001835-0s7ok4uw	3111	24	.	.	.
cord-001835-0s7ok4uw	3112	1	With	with	IN
cord-001835-0s7ok4uw	3112	2	W229F	W229F	NNPS
cord-001835-0s7ok4uw	3112	3	and	and	CC
cord-001835-0s7ok4uw	3112	4	W229Y	w229y	JJ
cord-001835-0s7ok4uw	3112	5	mutations	mutation	NNS
cord-001835-0s7ok4uw	3112	6	,	,	,
cord-001835-0s7ok4uw	3112	7	the	the	DT
cord-001835-0s7ok4uw	3112	8	remaining	remain	VBG
cord-001835-0s7ok4uw	3112	9	activity	activity	NN
cord-001835-0s7ok4uw	3112	10	was	be	VBD
cord-001835-0s7ok4uw	3112	11	approximately	approximately	RB
cord-001835-0s7ok4uw	3112	12	10	10	CD
cord-001835-0s7ok4uw	3112	13	%	%	NN
cord-001835-0s7ok4uw	3112	14	of	of	IN
cord-001835-0s7ok4uw	3112	15	the	the	DT
cord-001835-0s7ok4uw	3112	16	initial	initial	JJ
cord-001835-0s7ok4uw	3112	17	activity	activity	NN
cord-001835-0s7ok4uw	3112	18	.	.	.
cord-001835-0s7ok4uw	3113	1	However	however	RB
cord-001835-0s7ok4uw	3113	2	with	with	IN
cord-001835-0s7ok4uw	3113	3	the	the	DT
cord-001835-0s7ok4uw	3113	4	W229A	W229A	NNS
cord-001835-0s7ok4uw	3113	5	mutation	mutation	NN
cord-001835-0s7ok4uw	3113	6	,	,	,
cord-001835-0s7ok4uw	3113	7	activity	activity	NN
cord-001835-0s7ok4uw	3113	8	was	be	VBD
cord-001835-0s7ok4uw	3113	9	totally	totally	RB
cord-001835-0s7ok4uw	3113	10	lost	lose	VBN
cord-001835-0s7ok4uw	3113	11	.	.	.
cord-001835-0s7ok4uw	3114	1	Structural	structural	JJ
cord-001835-0s7ok4uw	3114	2	studies	study	NNS
cord-001835-0s7ok4uw	3114	3	of	of	IN
cord-001835-0s7ok4uw	3114	4	the	the	DT
cord-001835-0s7ok4uw	3114	5	W229A	W229A	NNS
cord-001835-0s7ok4uw	3114	6	mutant	mutant	JJ
cord-001835-0s7ok4uw	3114	7	with	with	IN
cord-001835-0s7ok4uw	3114	8	CD	cd	NN
cord-001835-0s7ok4uw	3114	9	and	and	CC
cord-001835-0s7ok4uw	3114	10	florescence	florescence	NN
cord-001835-0s7ok4uw	3114	11	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	3114	12	indicated	indicate	VBD
cord-001835-0s7ok4uw	3114	13	that	that	IN
cord-001835-0s7ok4uw	3114	14	there	there	EX
cord-001835-0s7ok4uw	3114	15	was	be	VBD
cord-001835-0s7ok4uw	3114	16	no	no	DT
cord-001835-0s7ok4uw	3114	17	major	major	JJ
cord-001835-0s7ok4uw	3114	18	change	change	NN
cord-001835-0s7ok4uw	3114	19	in	in	IN
cord-001835-0s7ok4uw	3114	20	the	the	DT
cord-001835-0s7ok4uw	3114	21	overall	overall	JJ
cord-001835-0s7ok4uw	3114	22	structure	structure	NN
cord-001835-0s7ok4uw	3114	23	.	.	.
cord-001835-0s7ok4uw	3115	1	However	however	RB
cord-001835-0s7ok4uw	3115	2	this	this	DT
cord-001835-0s7ok4uw	3115	3	mutation	mutation	NN
cord-001835-0s7ok4uw	3115	4	disrupted	disrupt	VBD
cord-001835-0s7ok4uw	3115	5	the	the	DT
cord-001835-0s7ok4uw	3115	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	3115	7	of	of	IN
cord-001835-0s7ok4uw	3115	8	W229	w229	NN
cord-001835-0s7ok4uw	3115	9	which	which	WDT
cord-001835-0s7ok4uw	3115	10	resulted	result	VBD
cord-001835-0s7ok4uw	3115	11	in	in	IN
cord-001835-0s7ok4uw	3115	12	an	an	DT
cord-001835-0s7ok4uw	3115	13	increase	increase	NN
cord-001835-0s7ok4uw	3115	14	in	in	IN
cord-001835-0s7ok4uw	3115	15	the	the	DT
cord-001835-0s7ok4uw	3115	16	flexibility	flexibility	NN
cord-001835-0s7ok4uw	3115	17	of	of	IN
cord-001835-0s7ok4uw	3115	18	this	this	DT
cord-001835-0s7ok4uw	3115	19	region	region	NN
cord-001835-0s7ok4uw	3115	20	of	of	IN
cord-001835-0s7ok4uw	3115	21	the	the	DT
cord-001835-0s7ok4uw	3115	22	protein	protein	NN
cord-001835-0s7ok4uw	3115	23	.	.	.
cord-001835-0s7ok4uw	3116	1	This	this	DT
cord-001835-0s7ok4uw	3116	2	project	project	NN
cord-001835-0s7ok4uw	3116	3	was	be	VBD
cord-001835-0s7ok4uw	3116	4	supported	support	VBN
cord-001835-0s7ok4uw	3116	5	by	by	IN
cord-001835-0s7ok4uw	3116	6	T	T	NNP
cord-001835-0s7ok4uw	3116	7	€	€	HYPH
cord-001835-0s7ok4uw	3116	8	UB	UB	NNP
cord-001835-0s7ok4uw	3116	9	_	_	NNP
cord-001835-0s7ok4uw	3116	10	ITAK	ITAK	NNP
cord-001835-0s7ok4uw	3116	11	project	project	NN
cord-001835-0s7ok4uw	3117	1	no	no	DT
cord-001835-0s7ok4uw	3117	2	113M533	113m533	CD
cord-001835-0s7ok4uw	3117	3	.	.	.
cord-001835-0s7ok4uw	3118	1	Light	light	JJ
cord-001835-0s7ok4uw	3118	2	-	-	HYPH
cord-001835-0s7ok4uw	3118	3	switchable	switchable	JJ
cord-001835-0s7ok4uw	3118	4	Zn21	zn21	XX
cord-001835-0s7ok4uw	3119	1	binding	bind	VBG
cord-001835-0s7ok4uw	3119	2	proteins	protein	NNS
cord-001835-0s7ok4uw	3119	3	to	to	TO
cord-001835-0s7ok4uw	3119	4	study	study	VB
cord-001835-0s7ok4uw	3119	5	the	the	DT
cord-001835-0s7ok4uw	3119	6	role	role	NN
cord-001835-0s7ok4uw	3119	7	of	of	IN
cord-001835-0s7ok4uw	3119	8	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3119	9	Zn21	zn21	NN
cord-001835-0s7ok4uw	3120	1	signaling	signal	VBG
cord-001835-0s7ok4uw	3120	2	Stijn	Stijn	NNP
cord-001835-0s7ok4uw	3120	3	Aper	Aper	NNP
cord-001835-0s7ok4uw	3120	4	1	1	CD
cord-001835-0s7ok4uw	3120	5	,	,	,
cord-001835-0s7ok4uw	3120	6	Maarten	Maarten	NNP
cord-001835-0s7ok4uw	3120	7	Merkx	Merkx	NNP
cord-001835-0s7ok4uw	3120	8	1	1	CD
cord-001835-0s7ok4uw	3120	9	1	1	CD
cord-001835-0s7ok4uw	3120	10	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	3120	11	plays	play	VBZ
cord-001835-0s7ok4uw	3120	12	an	an	DT
cord-001835-0s7ok4uw	3120	13	important	important	JJ
cord-001835-0s7ok4uw	3120	14	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3120	15	and	and	CC
cord-001835-0s7ok4uw	3120	16	structural	structural	JJ
cord-001835-0s7ok4uw	3120	17	role	role	NN
cord-001835-0s7ok4uw	3120	18	in	in	IN
cord-001835-0s7ok4uw	3120	19	many	many	JJ
cord-001835-0s7ok4uw	3120	20	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	3120	21	cellular	cellular	JJ
cord-001835-0s7ok4uw	3120	22	processes	process	NNS
cord-001835-0s7ok4uw	3120	23	and	and	CC
cord-001835-0s7ok4uw	3120	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3120	25	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	3120	26	is	be	VBZ
cord-001835-0s7ok4uw	3120	27	tightly	tightly	RB
cord-001835-0s7ok4uw	3120	28	controlled	control	VBN
cord-001835-0s7ok4uw	3120	29	.	.	.
cord-001835-0s7ok4uw	3121	1	Recently	recently	RB
cord-001835-0s7ok4uw	3121	2	,	,	,
cord-001835-0s7ok4uw	3121	3	free	free	JJ
cord-001835-0s7ok4uw	3121	4	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	3121	5	has	have	VBZ
cord-001835-0s7ok4uw	3121	6	also	also	RB
cord-001835-0s7ok4uw	3121	7	been	be	VBN
cord-001835-0s7ok4uw	3121	8	suggested	suggest	VBN
cord-001835-0s7ok4uw	3121	9	to	to	TO
cord-001835-0s7ok4uw	3121	10	act	act	VB
cord-001835-0s7ok4uw	3121	11	as	as	IN
cord-001835-0s7ok4uw	3121	12	an	an	DT
cord-001835-0s7ok4uw	3121	13	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3121	14	signaling	signaling	NN
cord-001835-0s7ok4uw	3121	15	molecule	molecule	NN
cord-001835-0s7ok4uw	3121	16	.	.	.
cord-001835-0s7ok4uw	3122	1	To	to	TO
cord-001835-0s7ok4uw	3122	2	get	get	VB
cord-001835-0s7ok4uw	3122	3	increased	increase	VBN
cord-001835-0s7ok4uw	3122	4	understanding	understanding	NN
cord-001835-0s7ok4uw	3122	5	of	of	IN
cord-001835-0s7ok4uw	3122	6	the	the	DT
cord-001835-0s7ok4uw	3122	7	signaling	signal	VBG
cord-001835-0s7ok4uw	3122	8	role	role	NN
cord-001835-0s7ok4uw	3122	9	of	of	IN
cord-001835-0s7ok4uw	3122	10	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	3123	1	we	-PRON-	PRP
cord-001835-0s7ok4uw	3123	2	are	be	VBP
cord-001835-0s7ok4uw	3123	3	developing	develop	VBG
cord-001835-0s7ok4uw	3123	4	light	light	JJ
cord-001835-0s7ok4uw	3123	5	-	-	HYPH
cord-001835-0s7ok4uw	3123	6	switchable	switchable	JJ
cord-001835-0s7ok4uw	3123	7	Zn21	zn21	XX
cord-001835-0s7ok4uw	3124	1	binding	bind	VBG
cord-001835-0s7ok4uw	3124	2	proteins	protein	NNS
cord-001835-0s7ok4uw	3124	3	to	to	TO
cord-001835-0s7ok4uw	3124	4	perturb	perturb	VB
cord-001835-0s7ok4uw	3124	5	the	the	DT
cord-001835-0s7ok4uw	3124	6	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3124	7	Zn21	zn21	NN
cord-001835-0s7ok4uw	3125	1	concentration	concentration	NN
cord-001835-0s7ok4uw	3125	2	using	use	VBG
cord-001835-0s7ok4uw	3125	3	light	light	NN
cord-001835-0s7ok4uw	3125	4	.	.	.
cord-001835-0s7ok4uw	3126	1	These	these	DT
cord-001835-0s7ok4uw	3126	2	protein	protein	NN
cord-001835-0s7ok4uw	3126	3	switches	switch	NNS
cord-001835-0s7ok4uw	3126	4	consist	consist	VBP
cord-001835-0s7ok4uw	3126	5	of	of	IN
cord-001835-0s7ok4uw	3126	6	two	two	CD
cord-001835-0s7ok4uw	3126	7	light	light	JJ
cord-001835-0s7ok4uw	3126	8	-	-	HYPH
cord-001835-0s7ok4uw	3126	9	responsive	responsive	JJ
cord-001835-0s7ok4uw	3126	10	Vivid	vivid	JJ
cord-001835-0s7ok4uw	3126	11	domains	domain	NNS
cord-001835-0s7ok4uw	3126	12	and	and	CC
cord-001835-0s7ok4uw	3126	13	the	the	DT
cord-001835-0s7ok4uw	3126	14	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	3126	15	binding	bind	VBG
cord-001835-0s7ok4uw	3126	16	domains	domain	NNS
cord-001835-0s7ok4uw	3126	17	Atox1	Atox1	NNP
cord-001835-0s7ok4uw	3126	18	and	and	CC
cord-001835-0s7ok4uw	3126	19	WD4	WD4	NNP
cord-001835-0s7ok4uw	3126	20	,	,	,
cord-001835-0s7ok4uw	3126	21	linked	link	VBN
cord-001835-0s7ok4uw	3126	22	together	together	RB
cord-001835-0s7ok4uw	3126	23	with	with	IN
cord-001835-0s7ok4uw	3126	24	flexible	flexible	JJ
cord-001835-0s7ok4uw	3126	25	peptide	peptide	NN
cord-001835-0s7ok4uw	3126	26	linkers	linker	NNS
cord-001835-0s7ok4uw	3126	27	.	.	.
cord-001835-0s7ok4uw	3127	1	In	in	IN
cord-001835-0s7ok4uw	3127	2	the	the	DT
cord-001835-0s7ok4uw	3127	3	dark	dark	NN
cord-001835-0s7ok4uw	3127	4	,	,	,
cord-001835-0s7ok4uw	3127	5	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	3127	6	is	be	VBZ
cord-001835-0s7ok4uw	3127	7	tightly	tightly	RB
cord-001835-0s7ok4uw	3127	8	bound	bind	VBN
cord-001835-0s7ok4uw	3127	9	in	in	RP
cord-001835-0s7ok4uw	3127	10	between	between	IN
cord-001835-0s7ok4uw	3127	11	the	the	DT
cord-001835-0s7ok4uw	3127	12	two	two	CD
cord-001835-0s7ok4uw	3127	13	Zn21	zn21	NN
cord-001835-0s7ok4uw	3128	1	binding	bind	VBG
cord-001835-0s7ok4uw	3128	2	proteins	protein	NNS
cord-001835-0s7ok4uw	3128	3	.	.	.
cord-001835-0s7ok4uw	3129	1	Light	light	NN
cord-001835-0s7ok4uw	3129	2	-	-	HYPH
cord-001835-0s7ok4uw	3129	3	induced	induce	VBN
cord-001835-0s7ok4uw	3129	4	dimerization	dimerization	NN
cord-001835-0s7ok4uw	3129	5	of	of	IN
cord-001835-0s7ok4uw	3129	6	the	the	DT
cord-001835-0s7ok4uw	3129	7	Vivid	vivid	JJ
cord-001835-0s7ok4uw	3129	8	proteins	protein	NNS
cord-001835-0s7ok4uw	3129	9	disrupts	disrupt	VBZ
cord-001835-0s7ok4uw	3129	10	this	this	DT
cord-001835-0s7ok4uw	3129	11	interaction	interaction	NN
cord-001835-0s7ok4uw	3129	12	and	and	CC
cord-001835-0s7ok4uw	3129	13	thus	thus	RB
cord-001835-0s7ok4uw	3129	14	results	result	VBZ
cord-001835-0s7ok4uw	3129	15	in	in	IN
cord-001835-0s7ok4uw	3129	16	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	3130	1	release	release	NN
cord-001835-0s7ok4uw	3130	2	.	.	.
cord-001835-0s7ok4uw	3131	1	The	the	DT
cord-001835-0s7ok4uw	3131	2	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	3131	3	proteins	protein	NNS
cord-001835-0s7ok4uw	3132	1	Cerulean	Cerulean	NNP
cord-001835-0s7ok4uw	3132	2	and	and	CC
cord-001835-0s7ok4uw	3132	3	Citrine	Citrine	NNP
cord-001835-0s7ok4uw	3132	4	were	be	VBD
cord-001835-0s7ok4uw	3132	5	attached	attach	VBN
cord-001835-0s7ok4uw	3132	6	to	to	IN
cord-001835-0s7ok4uw	3132	7	the	the	DT
cord-001835-0s7ok4uw	3132	8	Vivid	vivid	JJ
cord-001835-0s7ok4uw	3132	9	domains	domain	NNS
cord-001835-0s7ok4uw	3132	10	to	to	TO
cord-001835-0s7ok4uw	3132	11	allow	allow	VB
cord-001835-0s7ok4uw	3132	12	the	the	DT
cord-001835-0s7ok4uw	3132	13	different	different	JJ
cord-001835-0s7ok4uw	3132	14	conformational	conformational	JJ
cord-001835-0s7ok4uw	3132	15	states	state	NNS
cord-001835-0s7ok4uw	3132	16	of	of	IN
cord-001835-0s7ok4uw	3132	17	the	the	DT
cord-001835-0s7ok4uw	3132	18	protein	protein	NN
cord-001835-0s7ok4uw	3132	19	switch	switch	NN
cord-001835-0s7ok4uw	3132	20	to	to	TO
cord-001835-0s7ok4uw	3132	21	be	be	VB
cord-001835-0s7ok4uw	3132	22	monitored	monitor	VBN
cord-001835-0s7ok4uw	3132	23	using	use	VBG
cord-001835-0s7ok4uw	3132	24	FRET	fret	NN
cord-001835-0s7ok4uw	3132	25	.	.	.
cord-001835-0s7ok4uw	3133	1	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	3134	1	titrations	titration	NNS
cord-001835-0s7ok4uw	3134	2	revealed	reveal	VBD
cord-001835-0s7ok4uw	3134	3	a	a	DT
cord-001835-0s7ok4uw	3134	4	3-fold	3-fold	CD
cord-001835-0s7ok4uw	3134	5	decrease	decrease	NN
cord-001835-0s7ok4uw	3134	6	in	in	IN
cord-001835-0s7ok4uw	3134	7	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	3135	1	affinity	affinity	NN
cord-001835-0s7ok4uw	3135	2	going	go	VBG
cord-001835-0s7ok4uw	3135	3	from	from	IN
cord-001835-0s7ok4uw	3135	4	dark	dark	NN
cord-001835-0s7ok4uw	3135	5	-	-	HYPH
cord-001835-0s7ok4uw	3135	6	to	to	IN
cord-001835-0s7ok4uw	3135	7	light	light	JJ
cord-001835-0s7ok4uw	3135	8	-	-	HYPH
cord-001835-0s7ok4uw	3135	9	state	state	NN
cord-001835-0s7ok4uw	3135	10	for	for	IN
cord-001835-0s7ok4uw	3135	11	the	the	DT
cord-001835-0s7ok4uw	3135	12	initial	initial	JJ
cord-001835-0s7ok4uw	3135	13	design	design	NN
cord-001835-0s7ok4uw	3135	14	,	,	,
cord-001835-0s7ok4uw	3135	15	which	which	WDT
cord-001835-0s7ok4uw	3135	16	was	be	VBD
cord-001835-0s7ok4uw	3135	17	further	further	RB
cord-001835-0s7ok4uw	3135	18	improved	improve	VBN
cord-001835-0s7ok4uw	3135	19	to	to	IN
cord-001835-0s7ok4uw	3135	20	10-fold	10-fold	CD
cord-001835-0s7ok4uw	3135	21	by	by	IN
cord-001835-0s7ok4uw	3135	22	optimizing	optimize	VBG
cord-001835-0s7ok4uw	3135	23	the	the	DT
cord-001835-0s7ok4uw	3135	24	linkers	linker	NNS
cord-001835-0s7ok4uw	3135	25	between	between	IN
cord-001835-0s7ok4uw	3135	26	the	the	DT
cord-001835-0s7ok4uw	3135	27	protein	protein	NN
cord-001835-0s7ok4uw	3135	28	domains	domain	NNS
cord-001835-0s7ok4uw	3135	29	.	.	.
cord-001835-0s7ok4uw	3136	1	In	in	IN
cord-001835-0s7ok4uw	3136	2	addition	addition	NN
cord-001835-0s7ok4uw	3136	3	,	,	,
cord-001835-0s7ok4uw	3136	4	the	the	DT
cord-001835-0s7ok4uw	3136	5	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	3136	6	affinities	affinity	NNS
cord-001835-0s7ok4uw	3136	7	of	of	IN
cord-001835-0s7ok4uw	3136	8	both	both	DT
cord-001835-0s7ok4uw	3136	9	states	state	NNS
cord-001835-0s7ok4uw	3136	10	were	be	VBD
cord-001835-0s7ok4uw	3136	11	tuned	tune	VBN
cord-001835-0s7ok4uw	3136	12	to	to	TO
cord-001835-0s7ok4uw	3136	13	be	be	VB
cord-001835-0s7ok4uw	3136	14	optimal	optimal	JJ
cord-001835-0s7ok4uw	3136	15	for	for	IN
cord-001835-0s7ok4uw	3136	16	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3136	17	applications	application	NNS
cord-001835-0s7ok4uw	3136	18	.	.	.
cord-001835-0s7ok4uw	3137	1	Switching	switch	VBG
cord-001835-0s7ok4uw	3137	2	between	between	IN
cord-001835-0s7ok4uw	3137	3	the	the	DT
cord-001835-0s7ok4uw	3137	4	high	high	JJ
cord-001835-0s7ok4uw	3137	5	affinity	affinity	NN
cord-001835-0s7ok4uw	3137	6	dark	dark	JJ
cord-001835-0s7ok4uw	3137	7	-	-	HYPH
cord-001835-0s7ok4uw	3137	8	state	state	NN
cord-001835-0s7ok4uw	3137	9	and	and	CC
cord-001835-0s7ok4uw	3137	10	the	the	DT
cord-001835-0s7ok4uw	3137	11	low	low	JJ
cord-001835-0s7ok4uw	3137	12	affinity	affinity	NN
cord-001835-0s7ok4uw	3137	13	lightstate	lightstate	NN
cord-001835-0s7ok4uw	3137	14	was	be	VBD
cord-001835-0s7ok4uw	3137	15	found	find	VBN
cord-001835-0s7ok4uw	3137	16	to	to	TO
cord-001835-0s7ok4uw	3137	17	be	be	VB
cord-001835-0s7ok4uw	3137	18	reversible	reversible	JJ
cord-001835-0s7ok4uw	3137	19	for	for	IN
cord-001835-0s7ok4uw	3137	20	at	at	RB
cord-001835-0s7ok4uw	3137	21	least	least	RBS
cord-001835-0s7ok4uw	3137	22	two	two	CD
cord-001835-0s7ok4uw	3137	23	light	light	JJ
cord-001835-0s7ok4uw	3137	24	-	-	HYPH
cord-001835-0s7ok4uw	3137	25	dark	dark	JJ
cord-001835-0s7ok4uw	3137	26	cycles	cycle	NNS
cord-001835-0s7ok4uw	3137	27	.	.	.
cord-001835-0s7ok4uw	3138	1	Following	follow	VBG
cord-001835-0s7ok4uw	3138	2	the	the	DT
cord-001835-0s7ok4uw	3138	3	in	in	FW
cord-001835-0s7ok4uw	3138	4	vitro	vitro	FW
cord-001835-0s7ok4uw	3138	5	characterization	characterization	NN
cord-001835-0s7ok4uw	3138	6	,	,	,
cord-001835-0s7ok4uw	3138	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	3138	8	are	be	VBP
cord-001835-0s7ok4uw	3138	9	currently	currently	RB
cord-001835-0s7ok4uw	3138	10	assessing	assess	VBG
cord-001835-0s7ok4uw	3138	11	the	the	DT
cord-001835-0s7ok4uw	3138	12	performance	performance	NN
cord-001835-0s7ok4uw	3138	13	of	of	IN
cord-001835-0s7ok4uw	3138	14	this	this	DT
cord-001835-0s7ok4uw	3138	15	genetically	genetically	RB
cord-001835-0s7ok4uw	3138	16	encoded	encode	VBN
cord-001835-0s7ok4uw	3138	17	'	'	``
cord-001835-0s7ok4uw	3138	18	caged	cage	VBN
cord-001835-0s7ok4uw	3138	19	'	'	''
cord-001835-0s7ok4uw	3138	20	Zn21	zn21	NN
cord-001835-0s7ok4uw	3139	1	in	in	IN
cord-001835-0s7ok4uw	3139	2	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	3139	3	cells	cell	NNS
cord-001835-0s7ok4uw	3139	4	.	.	.
cord-001835-0s7ok4uw	3140	1	Proteins	protein	NNS
cord-001835-0s7ok4uw	3140	2	as	as	IN
cord-001835-0s7ok4uw	3140	3	supramolecular	supramolecular	JJ
cord-001835-0s7ok4uw	3140	4	building	building	NN
cord-001835-0s7ok4uw	3140	5	blocks	block	NNS
cord-001835-0s7ok4uw	3140	6	:	:	:
cord-001835-0s7ok4uw	3140	7	engineering	engineer	VBG
cord-001835-0s7ok4uw	3140	8	nanoscale	nanoscale	NN
cord-001835-0s7ok4uw	3140	9	structures	structure	NNS
cord-001835-0s7ok4uw	3140	10	5	5	CD
cord-001835-0s7ok4uw	3140	11	School	School	NNP
cord-001835-0s7ok4uw	3140	12	of	of	IN
cord-001835-0s7ok4uw	3140	13	Biological	Biological	NNP
cord-001835-0s7ok4uw	3140	14	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	3140	15	,	,	,
cord-001835-0s7ok4uw	3140	16	University	University	NNP
cord-001835-0s7ok4uw	3140	17	of	of	IN
cord-001835-0s7ok4uw	3140	18	Auckland	Auckland	NNP
cord-001835-0s7ok4uw	3140	19	,	,	,
cord-001835-0s7ok4uw	3140	20	6	6	CD
cord-001835-0s7ok4uw	3140	21	School	School	NNP
cord-001835-0s7ok4uw	3140	22	of	of	IN
cord-001835-0s7ok4uw	3140	23	Biological	Biological	NNP
cord-001835-0s7ok4uw	3140	24	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	3140	25	,	,	,
cord-001835-0s7ok4uw	3140	26	Victoria	Victoria	NNP
cord-001835-0s7ok4uw	3140	27	University	University	NNP
cord-001835-0s7ok4uw	3140	28	Proteins	Proteins	NNP
cord-001835-0s7ok4uw	3140	29	hold	hold	VBP
cord-001835-0s7ok4uw	3140	30	great	great	JJ
cord-001835-0s7ok4uw	3140	31	promise	promise	NN
cord-001835-0s7ok4uw	3140	32	in	in	IN
cord-001835-0s7ok4uw	3140	33	forming	form	VBG
cord-001835-0s7ok4uw	3140	34	complex	complex	JJ
cord-001835-0s7ok4uw	3140	35	nanoscale	nanoscale	JJ
cord-001835-0s7ok4uw	3140	36	structures	structure	NNS
cord-001835-0s7ok4uw	3140	37	which	which	WDT
cord-001835-0s7ok4uw	3140	38	could	could	MD
cord-001835-0s7ok4uw	3140	39	be	be	VB
cord-001835-0s7ok4uw	3140	40	used	use	VBN
cord-001835-0s7ok4uw	3140	41	in	in	IN
cord-001835-0s7ok4uw	3140	42	the	the	DT
cord-001835-0s7ok4uw	3140	43	development	development	NN
cord-001835-0s7ok4uw	3140	44	of	of	IN
cord-001835-0s7ok4uw	3140	45	new	new	JJ
cord-001835-0s7ok4uw	3140	46	nanomaterials	nanomaterial	NNS
cord-001835-0s7ok4uw	3140	47	,	,	,
cord-001835-0s7ok4uw	3140	48	devices	device	NNS
cord-001835-0s7ok4uw	3140	49	,	,	,
cord-001835-0s7ok4uw	3140	50	biosensors	biosensor	NNS
cord-001835-0s7ok4uw	3140	51	,	,	,
cord-001835-0s7ok4uw	3140	52	electronics	electronic	NNS
cord-001835-0s7ok4uw	3140	53	and	and	CC
cord-001835-0s7ok4uw	3140	54	pharmaceuticals	pharmaceutical	NNS
cord-001835-0s7ok4uw	3140	55	.	.	.
cord-001835-0s7ok4uw	3141	1	The	the	DT
cord-001835-0s7ok4uw	3141	2	potential	potential	NN
cord-001835-0s7ok4uw	3141	3	to	to	TO
cord-001835-0s7ok4uw	3141	4	produce	produce	VB
cord-001835-0s7ok4uw	3141	5	nanomaterials	nanomaterial	NNS
cord-001835-0s7ok4uw	3141	6	from	from	IN
cord-001835-0s7ok4uw	3141	7	proteins	protein	NNS
cord-001835-0s7ok4uw	3141	8	is	be	VBZ
cord-001835-0s7ok4uw	3141	9	well	well	RB
cord-001835-0s7ok4uw	3141	10	supported	support	VBN
cord-001835-0s7ok4uw	3141	11	by	by	IN
cord-001835-0s7ok4uw	3141	12	the	the	DT
cord-001835-0s7ok4uw	3141	13	numerous	numerous	JJ
cord-001835-0s7ok4uw	3141	14	examples	example	NNS
cord-001835-0s7ok4uw	3141	15	of	of	IN
cord-001835-0s7ok4uw	3141	16	self	self	NN
cord-001835-0s7ok4uw	3141	17	-	-	HYPH
cord-001835-0s7ok4uw	3141	18	assembling	assemble	VBG
cord-001835-0s7ok4uw	3141	19	proteins	protein	NNS
cord-001835-0s7ok4uw	3141	20	found	find	VBN
cord-001835-0s7ok4uw	3141	21	in	in	IN
cord-001835-0s7ok4uw	3141	22	nature	nature	NN
cord-001835-0s7ok4uw	3141	23	.	.	.
cord-001835-0s7ok4uw	3142	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3142	2	are	be	VBP
cord-001835-0s7ok4uw	3142	3	exploring	explore	VBG
cord-001835-0s7ok4uw	3142	4	self	self	NN
cord-001835-0s7ok4uw	3142	5	-	-	HYPH
cord-001835-0s7ok4uw	3142	6	assembling	assemble	VBG
cord-001835-0s7ok4uw	3142	7	proteins	protein	NNS
cord-001835-0s7ok4uw	3142	8	for	for	IN
cord-001835-0s7ok4uw	3142	9	use	use	NN
cord-001835-0s7ok4uw	3142	10	as	as	IN
cord-001835-0s7ok4uw	3142	11	supramolecular	supramolecular	JJ
cord-001835-0s7ok4uw	3142	12	building	building	NN
cord-001835-0s7ok4uw	3142	13	blocks	block	NNS
cord-001835-0s7ok4uw	3142	14	,	,	,
cord-001835-0s7ok4uw	3142	15	or	or	CC
cord-001835-0s7ok4uw	3142	16	tectons	tecton	NNS
cord-001835-0s7ok4uw	3142	17	,	,	,
cord-001835-0s7ok4uw	3142	18	specifically	specifically	RB
cord-001835-0s7ok4uw	3142	19	the	the	DT
cord-001835-0s7ok4uw	3142	20	N	n	CD
cord-001835-0s7ok4uw	3142	21	-	-	HYPH
cord-001835-0s7ok4uw	3142	22	terminal	terminal	NN
cord-001835-0s7ok4uw	3142	23	domain	domain	NN
cord-001835-0s7ok4uw	3142	24	of	of	IN
cord-001835-0s7ok4uw	3142	25	a	a	DT
cord-001835-0s7ok4uw	3142	26	DNA	dna	NN
cord-001835-0s7ok4uw	3142	27	binding	binding	NN
cord-001835-0s7ok4uw	3142	28	protein	protein	NN
cord-001835-0s7ok4uw	3142	29	(	(	-LRB-
cord-001835-0s7ok4uw	3142	30	Nterm	Nterm	NNP
cord-001835-0s7ok4uw	3142	31	-	-	HYPH
cord-001835-0s7ok4uw	3142	32	Lsr2	Lsr2	NNP
cord-001835-0s7ok4uw	3142	33	)	)	-RRB-
cord-001835-0s7ok4uw	3142	34	and	and	CC
cord-001835-0s7ok4uw	3142	35	a	a	DT
cord-001835-0s7ok4uw	3142	36	typical	typical	JJ
cord-001835-0s7ok4uw	3142	37	2-cys	2-cys	CD
cord-001835-0s7ok4uw	3142	38	peroxiredoxin	peroxiredoxin	NN
cord-001835-0s7ok4uw	3142	39	(	(	-LRB-
cord-001835-0s7ok4uw	3142	40	hsPrx3	hsprx3	NN
cord-001835-0s7ok4uw	3142	41	)	)	-RRB-
cord-001835-0s7ok4uw	3142	42	.	.	.
cord-001835-0s7ok4uw	3143	1	Non	non	JJ
cord-001835-0s7ok4uw	3143	2	-	-	JJ
cord-001835-0s7ok4uw	3143	3	native	native	JJ
cord-001835-0s7ok4uw	3143	4	forms	form	NNS
cord-001835-0s7ok4uw	3143	5	of	of	IN
cord-001835-0s7ok4uw	3143	6	these	these	DT
cord-001835-0s7ok4uw	3143	7	proteins	protein	NNS
cord-001835-0s7ok4uw	3143	8	have	have	VBP
cord-001835-0s7ok4uw	3143	9	been	be	VBN
cord-001835-0s7ok4uw	3143	10	designed	design	VBN
cord-001835-0s7ok4uw	3143	11	undergo	undergo	VBP
cord-001835-0s7ok4uw	3143	12	selfassembly	selfassembly	RB
cord-001835-0s7ok4uw	3143	13	into	into	IN
cord-001835-0s7ok4uw	3143	14	supramolecular	supramolecular	JJ
cord-001835-0s7ok4uw	3143	15	structures	structure	NNS
cord-001835-0s7ok4uw	3143	16	in	in	IN
cord-001835-0s7ok4uw	3143	17	a	a	DT
cord-001835-0s7ok4uw	3143	18	controllable	controllable	JJ
cord-001835-0s7ok4uw	3143	19	manner	manner	NN
cord-001835-0s7ok4uw	3143	20	.	.	.
cord-001835-0s7ok4uw	3144	1	Self	self	NN
cord-001835-0s7ok4uw	3144	2	-	-	HYPH
cord-001835-0s7ok4uw	3144	3	assembly	assembly	NN
cord-001835-0s7ok4uw	3144	4	of	of	IN
cord-001835-0s7ok4uw	3144	5	Nterm	Nterm	NNP
cord-001835-0s7ok4uw	3144	6	-	-	HYPH
cord-001835-0s7ok4uw	3144	7	Lsr2	Lsr2	NNP
cord-001835-0s7ok4uw	3144	8	is	be	VBZ
cord-001835-0s7ok4uw	3144	9	initiated	initiate	VBN
cord-001835-0s7ok4uw	3144	10	via	via	IN
cord-001835-0s7ok4uw	3144	11	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	3144	12	cleavage	cleavage	NN
cord-001835-0s7ok4uw	3144	13	,	,	,
cord-001835-0s7ok4uw	3144	14	thereby	thereby	RB
cord-001835-0s7ok4uw	3144	15	allowing	allow	VBG
cord-001835-0s7ok4uw	3144	16	us	-PRON-	PRP
cord-001835-0s7ok4uw	3144	17	to	to	TO
cord-001835-0s7ok4uw	3144	18	generate	generate	VB
cord-001835-0s7ok4uw	3144	19	supramolecular	supramolecular	JJ
cord-001835-0s7ok4uw	3144	20	assemblies	assembly	NNS
cord-001835-0s7ok4uw	3144	21	in	in	IN
cord-001835-0s7ok4uw	3144	22	response	response	NN
cord-001835-0s7ok4uw	3144	23	to	to	IN
cord-001835-0s7ok4uw	3144	24	a	a	DT
cord-001835-0s7ok4uw	3144	25	specific	specific	JJ
cord-001835-0s7ok4uw	3144	26	trigger	trigger	NN
cord-001835-0s7ok4uw	3144	27	.	.	.
cord-001835-0s7ok4uw	3145	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3145	2	will	will	MD
cord-001835-0s7ok4uw	3145	3	show	show	VB
cord-001835-0s7ok4uw	3145	4	that	that	IN
cord-001835-0s7ok4uw	3145	5	the	the	DT
cord-001835-0s7ok4uw	3145	6	degree	degree	NN
cord-001835-0s7ok4uw	3145	7	of	of	IN
cord-001835-0s7ok4uw	3145	8	oligomerisation	oligomerisation	NN
cord-001835-0s7ok4uw	3145	9	can	can	MD
cord-001835-0s7ok4uw	3145	10	be	be	VB
cord-001835-0s7ok4uw	3145	11	controlled	control	VBN
cord-001835-0s7ok4uw	3145	12	by	by	IN
cord-001835-0s7ok4uw	3145	13	variations	variation	NNS
cord-001835-0s7ok4uw	3145	14	in	in	IN
cord-001835-0s7ok4uw	3145	15	environmental	environmental	JJ
cord-001835-0s7ok4uw	3145	16	conditions	condition	NNS
cord-001835-0s7ok4uw	3145	17	such	such	JJ
cord-001835-0s7ok4uw	3145	18	as	as	IN
cord-001835-0s7ok4uw	3145	19	pH	pH	NNP
cord-001835-0s7ok4uw	3145	20	and	and	CC
cord-001835-0s7ok4uw	3145	21	protein	protein	NN
cord-001835-0s7ok4uw	3145	22	concentration	concentration	NN
cord-001835-0s7ok4uw	3145	23	.	.	.
cord-001835-0s7ok4uw	3146	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	3146	2	,	,	,
cord-001835-0s7ok4uw	3146	3	via	via	IN
cord-001835-0s7ok4uw	3146	4	protein	protein	NN
cord-001835-0s7ok4uw	3146	5	engineering	engineering	NN
cord-001835-0s7ok4uw	3146	6	,	,	,
cord-001835-0s7ok4uw	3146	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	3146	8	have	have	VBP
cord-001835-0s7ok4uw	3146	9	introduced	introduce	VBN
cord-001835-0s7ok4uw	3146	10	a	a	DT
cord-001835-0s7ok4uw	3146	11	new	new	JJ
cord-001835-0s7ok4uw	3146	12	"	"	``
cord-001835-0s7ok4uw	3146	13	switch	switch	NN
cord-001835-0s7ok4uw	3146	14	"	"	''
cord-001835-0s7ok4uw	3146	15	for	for	IN
cord-001835-0s7ok4uw	3146	16	oligomerisation	oligomerisation	NN
cord-001835-0s7ok4uw	3146	17	via	via	IN
cord-001835-0s7ok4uw	3146	18	enteropeptidase	enteropeptidase	NN
cord-001835-0s7ok4uw	3146	19	cleavage	cleavage	NN
cord-001835-0s7ok4uw	3146	20	.	.	.
cord-001835-0s7ok4uw	3147	1	The	the	DT
cord-001835-0s7ok4uw	3147	2	new	new	JJ
cord-001835-0s7ok4uw	3147	3	construct	construct	NN
cord-001835-0s7ok4uw	3147	4	of	of	IN
cord-001835-0s7ok4uw	3147	5	Nterm	Nterm	NNP
cord-001835-0s7ok4uw	3147	6	-	-	HYPH
cord-001835-0s7ok4uw	3147	7	Lsr2	Lsr2	NNP
cord-001835-0s7ok4uw	3147	8	can	can	MD
cord-001835-0s7ok4uw	3147	9	be	be	VB
cord-001835-0s7ok4uw	3147	10	activated	activate	VBN
cord-001835-0s7ok4uw	3147	11	and	and	CC
cord-001835-0s7ok4uw	3147	12	assembled	assemble	VBN
cord-001835-0s7ok4uw	3147	13	in	in	IN
cord-001835-0s7ok4uw	3147	14	a	a	DT
cord-001835-0s7ok4uw	3147	15	controlled	control	VBN
cord-001835-0s7ok4uw	3147	16	fashion	fashion	NN
cord-001835-0s7ok4uw	3147	17	and	and	CC
cord-001835-0s7ok4uw	3147	18	provides	provide	VBZ
cord-001835-0s7ok4uw	3147	19	some	some	DT
cord-001835-0s7ok4uw	3147	20	ability	ability	NN
cord-001835-0s7ok4uw	3147	21	to	to	TO
cord-001835-0s7ok4uw	3147	22	alter	alter	VB
cord-001835-0s7ok4uw	3147	23	the	the	DT
cord-001835-0s7ok4uw	3147	24	ratio	ratio	NN
cord-001835-0s7ok4uw	3147	25	of	of	IN
cord-001835-0s7ok4uw	3147	26	higher	high	JJR
cord-001835-0s7ok4uw	3147	27	ordered	order	VBN
cord-001835-0s7ok4uw	3147	28	structures	structure	NNS
cord-001835-0s7ok4uw	3147	29	formed	form	VBN
cord-001835-0s7ok4uw	3147	30	.	.	.
cord-001835-0s7ok4uw	3148	1	hsPrx3	hsprx3	LS
cord-001835-0s7ok4uw	3148	2	has	have	VBZ
cord-001835-0s7ok4uw	3148	3	been	be	VBN
cord-001835-0s7ok4uw	3148	4	shown	show	VBN
cord-001835-0s7ok4uw	3148	5	to	to	IN
cord-001835-0s7ok4uw	3148	6	oligomerise	oligomerise	NNP
cord-001835-0s7ok4uw	3148	7	into	into	IN
cord-001835-0s7ok4uw	3148	8	dimers	dimer	NNS
cord-001835-0s7ok4uw	3148	9	,	,	,
cord-001835-0s7ok4uw	3148	10	toroids	toroid	NNS
cord-001835-0s7ok4uw	3148	11	,	,	,
cord-001835-0s7ok4uw	3148	12	stacks	stack	NNS
cord-001835-0s7ok4uw	3148	13	and	and	CC
cord-001835-0s7ok4uw	3148	14	tubes	tube	NNS
cord-001835-0s7ok4uw	3148	15	in	in	IN
cord-001835-0s7ok4uw	3148	16	response	response	NN
cord-001835-0s7ok4uw	3148	17	to	to	IN
cord-001835-0s7ok4uw	3148	18	specific	specific	JJ
cord-001835-0s7ok4uw	3148	19	triggers	trigger	NNS
cord-001835-0s7ok4uw	3148	20	such	such	JJ
cord-001835-0s7ok4uw	3148	21	as	as	IN
cord-001835-0s7ok4uw	3148	22	pH	pH	NNP
cord-001835-0s7ok4uw	3148	23	and	and	CC
cord-001835-0s7ok4uw	3148	24	redox	redox	NN
cord-001835-0s7ok4uw	3148	25	state	state	NN
cord-001835-0s7ok4uw	3148	26	.	.	.
cord-001835-0s7ok4uw	3149	1	In	in	IN
cord-001835-0s7ok4uw	3149	2	this	this	DT
cord-001835-0s7ok4uw	3149	3	work	work	NN
cord-001835-0s7ok4uw	3149	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3149	5	have	have	VBP
cord-001835-0s7ok4uw	3149	6	utilised	utilise	VBN
cord-001835-0s7ok4uw	3149	7	the	the	DT
cord-001835-0s7ok4uw	3149	8	histidine	histidine	NN
cord-001835-0s7ok4uw	3149	9	tag	tag	NN
cord-001835-0s7ok4uw	3149	10	to	to	TO
cord-001835-0s7ok4uw	3149	11	further	further	RB
cord-001835-0s7ok4uw	3149	12	control	control	VB
cord-001835-0s7ok4uw	3149	13	the	the	DT
cord-001835-0s7ok4uw	3149	14	assembly	assembly	NN
cord-001835-0s7ok4uw	3149	15	of	of	IN
cord-001835-0s7ok4uw	3149	16	this	this	DT
cord-001835-0s7ok4uw	3149	17	versatile	versatile	JJ
cord-001835-0s7ok4uw	3149	18	protein	protein	NN
cord-001835-0s7ok4uw	3149	19	tecton	tecton	NN
cord-001835-0s7ok4uw	3149	20	.	.	.
cord-001835-0s7ok4uw	3150	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3150	2	will	will	MD
cord-001835-0s7ok4uw	3150	3	show	show	VB
cord-001835-0s7ok4uw	3150	4	that	that	IN
cord-001835-0s7ok4uw	3150	5	minute	minute	NN
cord-001835-0s7ok4uw	3150	6	variations	variation	NNS
cord-001835-0s7ok4uw	3150	7	in	in	IN
cord-001835-0s7ok4uw	3150	8	pH	pH	NNP
cord-001835-0s7ok4uw	3150	9	can	can	MD
cord-001835-0s7ok4uw	3150	10	induce	induce	VB
cord-001835-0s7ok4uw	3150	11	oligomersation	oligomersation	NN
cord-001835-0s7ok4uw	3150	12	of	of	IN
cord-001835-0s7ok4uw	3150	13	hsPrx3	hsprx3	DT
cord-001835-0s7ok4uw	3150	14	toroids	toroid	NNS
cord-001835-0s7ok4uw	3150	15	into	into	IN
cord-001835-0s7ok4uw	3150	16	stacks	stack	NNS
cord-001835-0s7ok4uw	3150	17	and	and	CC
cord-001835-0s7ok4uw	3150	18	tubes	tube	NNS
cord-001835-0s7ok4uw	3150	19	.	.	.
cord-001835-0s7ok4uw	3151	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	3151	2	,	,	,
cord-001835-0s7ok4uw	3151	3	by	by	IN
cord-001835-0s7ok4uw	3151	4	utilising	utilise	VBG
cord-001835-0s7ok4uw	3151	5	the	the	DT
cord-001835-0s7ok4uw	3151	6	histidine	histidine	NN
cord-001835-0s7ok4uw	3151	7	tag	tag	NN
cord-001835-0s7ok4uw	3151	8	as	as	IN
cord-001835-0s7ok4uw	3151	9	a	a	DT
cord-001835-0s7ok4uw	3151	10	ligand	ligand	NN
cord-001835-0s7ok4uw	3151	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	3151	12	can	can	MD
cord-001835-0s7ok4uw	3151	13	bind	bind	VB
cord-001835-0s7ok4uw	3151	14	divalent	divalent	JJ
cord-001835-0s7ok4uw	3151	15	metals	metal	NNS
cord-001835-0s7ok4uw	3151	16	to	to	IN
cord-001835-0s7ok4uw	3151	17	these	these	DT
cord-001835-0s7ok4uw	3151	18	supramolecular	supramolecular	JJ
cord-001835-0s7ok4uw	3151	19	structures	structure	NNS
cord-001835-0s7ok4uw	3151	20	.	.	.
cord-001835-0s7ok4uw	3152	1	This	this	DT
cord-001835-0s7ok4uw	3152	2	not	not	RB
cord-001835-0s7ok4uw	3152	3	only	only	RB
cord-001835-0s7ok4uw	3152	4	drives	drive	VBZ
cord-001835-0s7ok4uw	3152	5	the	the	DT
cord-001835-0s7ok4uw	3152	6	formation	formation	NN
cord-001835-0s7ok4uw	3152	7	of	of	IN
cord-001835-0s7ok4uw	3152	8	higher	high	JJR
cord-001835-0s7ok4uw	3152	9	ordered	order	VBN
cord-001835-0s7ok4uw	3152	10	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	3152	11	but	but	CC
cord-001835-0s7ok4uw	3152	12	also	also	RB
cord-001835-0s7ok4uw	3152	13	provides	provide	VBZ
cord-001835-0s7ok4uw	3152	14	a	a	DT
cord-001835-0s7ok4uw	3152	15	facile	facile	JJ
cord-001835-0s7ok4uw	3152	16	route	route	NN
cord-001835-0s7ok4uw	3152	17	which	which	WDT
cord-001835-0s7ok4uw	3152	18	may	may	MD
cord-001835-0s7ok4uw	3152	19	facilitate	facilitate	VB
cord-001835-0s7ok4uw	3152	20	the	the	DT
cord-001835-0s7ok4uw	3152	21	functionalisation	functionalisation	NN
cord-001835-0s7ok4uw	3152	22	of	of	IN
cord-001835-0s7ok4uw	3152	23	these	these	DT
cord-001835-0s7ok4uw	3152	24	protein	protein	NN
cord-001835-0s7ok4uw	3152	25	nanoscale	nanoscale	NN
cord-001835-0s7ok4uw	3152	26	structures	structure	NNS
cord-001835-0s7ok4uw	3152	27	after	after	IN
cord-001835-0s7ok4uw	3152	28	they	-PRON-	PRP
cord-001835-0s7ok4uw	3152	29	have	have	VBP
cord-001835-0s7ok4uw	3152	30	been	be	VBN
cord-001835-0s7ok4uw	3152	31	assembled	assemble	VBN
cord-001835-0s7ok4uw	3152	32	.	.	.
cord-001835-0s7ok4uw	3153	1	Danielle	Danielle	NNP
cord-001835-0s7ok4uw	3153	2	Basore	Basore	NNP
cord-001835-0s7ok4uw	3153	3	1,2	1,2	CD
cord-001835-0s7ok4uw	3153	4	,	,	,
cord-001835-0s7ok4uw	3153	5	Rajesh	Rajesh	NNP
cord-001835-0s7ok4uw	3153	6	Naz	Naz	NNP
cord-001835-0s7ok4uw	3153	7	5	5	CD
cord-001835-0s7ok4uw	3153	8	,	,	,
cord-001835-0s7ok4uw	3153	9	Scott	Scott	NNP
cord-001835-0s7ok4uw	3153	10	Michael	Michael	NNP
cord-001835-0s7ok4uw	3153	11	6	6	CD
cord-001835-0s7ok4uw	3153	12	,	,	,
cord-001835-0s7ok4uw	3153	13	Sharon	Sharon	NNP
cord-001835-0s7ok4uw	3153	14	Isern	Isern	NNP
cord-001835-0s7ok4uw	3153	15	6	6	CD
cord-001835-0s7ok4uw	3153	16	,	,	,
cord-001835-0s7ok4uw	3153	17	Benjamin	Benjamin	NNP
cord-001835-0s7ok4uw	3153	18	Wright	Wright	NNP
cord-001835-0s7ok4uw	3153	19	3	3	CD
cord-001835-0s7ok4uw	3153	20	,	,	,
cord-001835-0s7ok4uw	3153	21	Katie	Katie	NNP
cord-001835-0s7ok4uw	3153	22	Saporita	Saporita	NNP
cord-001835-0s7ok4uw	3153	23	1	1	CD
cord-001835-0s7ok4uw	3153	24	,	,	,
cord-001835-0s7ok4uw	3153	25	Donna	Donna	NNP
cord-001835-0s7ok4uw	3153	26	Crone	Crone	NNP
cord-001835-0s7ok4uw	3153	27	1	1	CD
cord-001835-0s7ok4uw	3153	28	,	,	,
cord-001835-0s7ok4uw	3153	29	Christopher	Christopher	NNP
cord-001835-0s7ok4uw	3153	30	Bystroff	Bystroff	NNP
cord-001835-0s7ok4uw	3153	31	1,2,4	1,2,4	CD
cord-001835-0s7ok4uw	3153	32	1	1	CD
cord-001835-0s7ok4uw	3153	33	Biological	Biological	NNP
cord-001835-0s7ok4uw	3153	34	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	3153	35	,	,	,
cord-001835-0s7ok4uw	3153	36	Rensselaer	Rensselaer	NNP
cord-001835-0s7ok4uw	3153	37	Polytechnic	Polytechnic	NNP
cord-001835-0s7ok4uw	3153	38	Institute	Institute	NNP
cord-001835-0s7ok4uw	3153	39	,	,	,
cord-001835-0s7ok4uw	3153	40	2	2	CD
cord-001835-0s7ok4uw	3153	41	CBIS	CBIS	NNP
cord-001835-0s7ok4uw	3153	42	,	,	,
cord-001835-0s7ok4uw	3153	43	Rensselaer	Rensselaer	NNP
cord-001835-0s7ok4uw	3153	44	Polytechnic	Polytechnic	NNP
cord-001835-0s7ok4uw	3153	45	Institute	Institute	NNP
cord-001835-0s7ok4uw	3153	46	,	,	,
cord-001835-0s7ok4uw	3153	47	3	3	CD
cord-001835-0s7ok4uw	3153	48	Chemical	Chemical	NNP
cord-001835-0s7ok4uw	3153	49	and	and	CC
cord-001835-0s7ok4uw	3153	50	Biological	Biological	NNP
cord-001835-0s7ok4uw	3153	51	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	3153	52	,	,	,
cord-001835-0s7ok4uw	3153	53	Rensselaer	Rensselaer	NNP
cord-001835-0s7ok4uw	3153	54	Polytechnic	Polytechnic	NNP
cord-001835-0s7ok4uw	3153	55	Institute	Institute	NNP
cord-001835-0s7ok4uw	3153	56	,	,	,
cord-001835-0s7ok4uw	3153	57	4	4	CD
cord-001835-0s7ok4uw	3153	58	Computer	Computer	NNP
cord-001835-0s7ok4uw	3153	59	Science	Science	NNP
cord-001835-0s7ok4uw	3153	60	,	,	,
cord-001835-0s7ok4uw	3153	61	Rensselaer	Rensselaer	NNP
cord-001835-0s7ok4uw	3153	62	Polytechnic	Polytechnic	NNP
cord-001835-0s7ok4uw	3153	63	Institute	Institute	NNP
cord-001835-0s7ok4uw	3153	64	,	,	,
cord-001835-0s7ok4uw	3153	65	5	5	CD
cord-001835-0s7ok4uw	3153	66	Obstetrics	Obstetrics	NNPS
cord-001835-0s7ok4uw	3153	67	and	and	CC
cord-001835-0s7ok4uw	3153	68	Gynecology	Gynecology	NNP
cord-001835-0s7ok4uw	3153	69	,	,	,
cord-001835-0s7ok4uw	3153	70	West	West	NNP
cord-001835-0s7ok4uw	3153	71	Virginia	Virginia	NNP
cord-001835-0s7ok4uw	3153	72	University	University	NNP
cord-001835-0s7ok4uw	3153	73	,	,	,
cord-001835-0s7ok4uw	3153	74	6	6	CD
cord-001835-0s7ok4uw	3153	75	 	 	_SP
cord-001835-0s7ok4uw	3153	76	Unintended	unintended	JJ
cord-001835-0s7ok4uw	3153	77	pregnancy	pregnancy	NN
cord-001835-0s7ok4uw	3153	78	is	be	VBZ
cord-001835-0s7ok4uw	3153	79	a	a	DT
cord-001835-0s7ok4uw	3153	80	worldwide	worldwide	JJ
cord-001835-0s7ok4uw	3153	81	public	public	JJ
cord-001835-0s7ok4uw	3153	82	health	health	NN
cord-001835-0s7ok4uw	3153	83	concern	concern	NN
cord-001835-0s7ok4uw	3153	84	,	,	,
cord-001835-0s7ok4uw	3153	85	with	with	IN
cord-001835-0s7ok4uw	3153	86	85	85	CD
cord-001835-0s7ok4uw	3153	87	million	million	CD
cord-001835-0s7ok4uw	3153	88	pregnancies	pregnancy	NNS
cord-001835-0s7ok4uw	3153	89	being	be	VBG
cord-001835-0s7ok4uw	3153	90	classed	class	VBN
cord-001835-0s7ok4uw	3153	91	as	as	IN
cord-001835-0s7ok4uw	3153	92	unintended	unintended	JJ
cord-001835-0s7ok4uw	3153	93	in	in	IN
cord-001835-0s7ok4uw	3153	94	2012	2012	CD
cord-001835-0s7ok4uw	3153	95	.	.	.
cord-001835-0s7ok4uw	3154	1	The	the	DT
cord-001835-0s7ok4uw	3154	2	magnitude	magnitude	NN
cord-001835-0s7ok4uw	3154	3	of	of	IN
cord-001835-0s7ok4uw	3154	4	this	this	DT
cord-001835-0s7ok4uw	3154	5	number	number	NN
cord-001835-0s7ok4uw	3154	6	clearly	clearly	RB
cord-001835-0s7ok4uw	3154	7	indicates	indicate	VBZ
cord-001835-0s7ok4uw	3154	8	an	an	DT
cord-001835-0s7ok4uw	3154	9	unmet	unmet	JJ
cord-001835-0s7ok4uw	3154	10	need	need	NN
cord-001835-0s7ok4uw	3154	11	in	in	IN
cord-001835-0s7ok4uw	3154	12	terms	term	NNS
cord-001835-0s7ok4uw	3154	13	of	of	IN
cord-001835-0s7ok4uw	3154	14	contraception	contraception	NN
cord-001835-0s7ok4uw	3154	15	.	.	.
cord-001835-0s7ok4uw	3155	1	Methods	method	NNS
cord-001835-0s7ok4uw	3155	2	that	that	WDT
cord-001835-0s7ok4uw	3155	3	are	be	VBP
cord-001835-0s7ok4uw	3155	4	currently	currently	RB
cord-001835-0s7ok4uw	3155	5	available	available	JJ
cord-001835-0s7ok4uw	3155	6	are	be	VBP
cord-001835-0s7ok4uw	3155	7	effective	effective	JJ
cord-001835-0s7ok4uw	3155	8	,	,	,
cord-001835-0s7ok4uw	3155	9	but	but	CC
cord-001835-0s7ok4uw	3155	10	exhibit	exhibit	VB
cord-001835-0s7ok4uw	3155	11	many	many	JJ
cord-001835-0s7ok4uw	3155	12	problems	problem	NNS
cord-001835-0s7ok4uw	3155	13	.	.	.
cord-001835-0s7ok4uw	3156	1	Side	side	JJ
cord-001835-0s7ok4uw	3156	2	effects	effect	NNS
cord-001835-0s7ok4uw	3156	3	,	,	,
cord-001835-0s7ok4uw	3156	4	ease	ease	NN
cord-001835-0s7ok4uw	3156	5	of	of	IN
cord-001835-0s7ok4uw	3156	6	use	use	NN
cord-001835-0s7ok4uw	3156	7	,	,	,
cord-001835-0s7ok4uw	3156	8	cost	cost	NN
cord-001835-0s7ok4uw	3156	9	,	,	,
cord-001835-0s7ok4uw	3156	10	and	and	CC
cord-001835-0s7ok4uw	3156	11	availability	availability	NN
cord-001835-0s7ok4uw	3156	12	are	be	VBP
cord-001835-0s7ok4uw	3156	13	all	all	DT
cord-001835-0s7ok4uw	3156	14	concerns	concern	NNS
cord-001835-0s7ok4uw	3156	15	.	.	.
cord-001835-0s7ok4uw	3157	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3157	2	propose	propose	VBP
cord-001835-0s7ok4uw	3157	3	a	a	DT
cord-001835-0s7ok4uw	3157	4	contraceptive	contraceptive	JJ
cord-001835-0s7ok4uw	3157	5	vaccine	vaccine	NN
cord-001835-0s7ok4uw	3157	6	that	that	WDT
cord-001835-0s7ok4uw	3157	7	would	would	MD
cord-001835-0s7ok4uw	3157	8	be	be	VB
cord-001835-0s7ok4uw	3157	9	safe	safe	JJ
cord-001835-0s7ok4uw	3157	10	,	,	,
cord-001835-0s7ok4uw	3157	11	effective	effective	JJ
cord-001835-0s7ok4uw	3157	12	,	,	,
cord-001835-0s7ok4uw	3157	13	long	long	RB
cord-001835-0s7ok4uw	3157	14	-	-	HYPH
cord-001835-0s7ok4uw	3157	15	lasting	last	VBG
cord-001835-0s7ok4uw	3157	16	,	,	,
cord-001835-0s7ok4uw	3157	17	cheap	cheap	JJ
cord-001835-0s7ok4uw	3157	18	,	,	,
cord-001835-0s7ok4uw	3157	19	and	and	CC
cord-001835-0s7ok4uw	3157	20	reversible	reversible	JJ
cord-001835-0s7ok4uw	3157	21	.	.	.
cord-001835-0s7ok4uw	3158	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3158	2	vaccine	vaccine	NN
cord-001835-0s7ok4uw	3158	3	would	would	MD
cord-001835-0s7ok4uw	3158	4	prevent	prevent	VB
cord-001835-0s7ok4uw	3158	5	pregnancy	pregnancy	NN
cord-001835-0s7ok4uw	3158	6	by	by	IN
cord-001835-0s7ok4uw	3158	7	targeting	target	VBG
cord-001835-0s7ok4uw	3158	8	sperm	sperm	NN
cord-001835-0s7ok4uw	3158	9	with	with	IN
cord-001835-0s7ok4uw	3158	10	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3158	11	raised	raise	VBN
cord-001835-0s7ok4uw	3158	12	in	in	IN
cord-001835-0s7ok4uw	3158	13	the	the	DT
cord-001835-0s7ok4uw	3158	14	woman	woman	NN
cord-001835-0s7ok4uw	3158	15	's	's	POS
cord-001835-0s7ok4uw	3158	16	body	body	NN
cord-001835-0s7ok4uw	3158	17	.	.	.
cord-001835-0s7ok4uw	3159	1	Several	several	JJ
cord-001835-0s7ok4uw	3159	2	approaches	approach	NNS
cord-001835-0s7ok4uw	3159	3	have	have	VBP
cord-001835-0s7ok4uw	3159	4	been	be	VBN
cord-001835-0s7ok4uw	3159	5	taken	take	VBN
cord-001835-0s7ok4uw	3159	6	to	to	IN
cord-001835-0s7ok4uw	3159	7	developing	develop	VBG
cord-001835-0s7ok4uw	3159	8	a	a	DT
cord-001835-0s7ok4uw	3159	9	contraceptive	contraceptive	JJ
cord-001835-0s7ok4uw	3159	10	vaccine	vaccine	NN
cord-001835-0s7ok4uw	3159	11	in	in	IN
cord-001835-0s7ok4uw	3159	12	recent	recent	JJ
cord-001835-0s7ok4uw	3159	13	years	year	NNS
cord-001835-0s7ok4uw	3159	14	.	.	.
cord-001835-0s7ok4uw	3160	1	The	the	DT
cord-001835-0s7ok4uw	3160	2	most	most	RBS
cord-001835-0s7ok4uw	3160	3	successful	successful	JJ
cord-001835-0s7ok4uw	3160	4	so	so	RB
cord-001835-0s7ok4uw	3160	5	far	far	RB
cord-001835-0s7ok4uw	3160	6	has	have	VBZ
cord-001835-0s7ok4uw	3160	7	been	be	VBN
cord-001835-0s7ok4uw	3160	8	using	use	VBG
cord-001835-0s7ok4uw	3160	9	human	human	JJ
cord-001835-0s7ok4uw	3160	10	chorionic	chorionic	JJ
cord-001835-0s7ok4uw	3160	11	gonadotropin	gonadotropin	NN
cord-001835-0s7ok4uw	3160	12	(	(	-LRB-
cord-001835-0s7ok4uw	3160	13	hCG	hCG	NNP
cord-001835-0s7ok4uw	3160	14	)	)	-RRB-
cord-001835-0s7ok4uw	3160	15	,	,	,
cord-001835-0s7ok4uw	3160	16	a	a	DT
cord-001835-0s7ok4uw	3160	17	hormone	hormone	NN
cord-001835-0s7ok4uw	3160	18	produced	produce	VBN
cord-001835-0s7ok4uw	3160	19	during	during	IN
cord-001835-0s7ok4uw	3160	20	pregnancy	pregnancy	NN
cord-001835-0s7ok4uw	3160	21	,	,	,
cord-001835-0s7ok4uw	3160	22	as	as	IN
cord-001835-0s7ok4uw	3160	23	an	an	DT
cord-001835-0s7ok4uw	3160	24	antigen	antigen	NN
cord-001835-0s7ok4uw	3160	25	.	.	.
cord-001835-0s7ok4uw	3161	1	The	the	DT
cord-001835-0s7ok4uw	3161	2	hCG	hcg	JJ
cord-001835-0s7ok4uw	3161	3	vaccine	vaccine	NN
cord-001835-0s7ok4uw	3161	4	progressed	progress	VBD
cord-001835-0s7ok4uw	3161	5	to	to	TO
cord-001835-0s7ok4uw	3161	6	phase	phase	VB
cord-001835-0s7ok4uw	3161	7	2	2	CD
cord-001835-0s7ok4uw	3161	8	clinical	clinical	JJ
cord-001835-0s7ok4uw	3161	9	trials	trial	NNS
cord-001835-0s7ok4uw	3161	10	,	,	,
cord-001835-0s7ok4uw	3161	11	but	but	CC
cord-001835-0s7ok4uw	3161	12	only	only	RB
cord-001835-0s7ok4uw	3161	13	displayed	display	VBD
cord-001835-0s7ok4uw	3161	14	an	an	DT
cord-001835-0s7ok4uw	3161	15	80	80	CD
cord-001835-0s7ok4uw	3161	16	%	%	NN
cord-001835-0s7ok4uw	3161	17	efficacy	efficacy	NN
cord-001835-0s7ok4uw	3161	18	,	,	,
cord-001835-0s7ok4uw	3161	19	which	which	WDT
cord-001835-0s7ok4uw	3161	20	is	be	VBZ
cord-001835-0s7ok4uw	3161	21	insufficient	insufficient	JJ
cord-001835-0s7ok4uw	3161	22	for	for	IN
cord-001835-0s7ok4uw	3161	23	a	a	DT
cord-001835-0s7ok4uw	3161	24	contraceptive	contraceptive	NN
cord-001835-0s7ok4uw	3161	25	.	.	.
cord-001835-0s7ok4uw	3162	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3162	2	lab	lab	NN
cord-001835-0s7ok4uw	3162	3	uses	use	VBZ
cord-001835-0s7ok4uw	3162	4	a	a	DT
cord-001835-0s7ok4uw	3162	5	structure	structure	NN
cord-001835-0s7ok4uw	3162	6	based	base	VBN
cord-001835-0s7ok4uw	3162	7	approach	approach	NN
cord-001835-0s7ok4uw	3162	8	to	to	IN
cord-001835-0s7ok4uw	3162	9	the	the	DT
cord-001835-0s7ok4uw	3162	10	design	design	NN
cord-001835-0s7ok4uw	3162	11	of	of	IN
cord-001835-0s7ok4uw	3162	12	an	an	DT
cord-001835-0s7ok4uw	3162	13	anti	anti	JJ
cord-001835-0s7ok4uw	3162	14	-	-	JJ
cord-001835-0s7ok4uw	3162	15	sperm	sperm	JJ
cord-001835-0s7ok4uw	3162	16	antigenic	antigenic	JJ
cord-001835-0s7ok4uw	3162	17	protein	protein	NN
cord-001835-0s7ok4uw	3162	18	.	.	.
cord-001835-0s7ok4uw	3163	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3163	2	believe	believe	VBP
cord-001835-0s7ok4uw	3163	3	this	this	DT
cord-001835-0s7ok4uw	3163	4	will	will	MD
cord-001835-0s7ok4uw	3163	5	raise	raise	VB
cord-001835-0s7ok4uw	3163	6	a	a	DT
cord-001835-0s7ok4uw	3163	7	more	more	RBR
cord-001835-0s7ok4uw	3163	8	vigorous	vigorous	JJ
cord-001835-0s7ok4uw	3163	9	immune	immune	JJ
cord-001835-0s7ok4uw	3163	10	response	response	NN
cord-001835-0s7ok4uw	3163	11	that	that	WDT
cord-001835-0s7ok4uw	3163	12	will	will	MD
cord-001835-0s7ok4uw	3163	13	produce	produce	VB
cord-001835-0s7ok4uw	3163	14	a	a	DT
cord-001835-0s7ok4uw	3163	15	longer	long	RBR
cord-001835-0s7ok4uw	3163	16	lasting	lasting	JJ
cord-001835-0s7ok4uw	3163	17	titer	titer	NN
cord-001835-0s7ok4uw	3163	18	.	.	.
cord-001835-0s7ok4uw	3164	1	The	the	DT
cord-001835-0s7ok4uw	3164	2	CatSper	CatSper	NNP
cord-001835-0s7ok4uw	3164	3	complex	complex	NN
cord-001835-0s7ok4uw	3164	4	is	be	VBZ
cord-001835-0s7ok4uw	3164	5	a	a	DT
cord-001835-0s7ok4uw	3164	6	heterotetrameric	heterotetrameric	JJ
cord-001835-0s7ok4uw	3164	7	calcium	calcium	NN
cord-001835-0s7ok4uw	3164	8	channel	channel	NN
cord-001835-0s7ok4uw	3164	9	found	find	VBN
cord-001835-0s7ok4uw	3164	10	in	in	IN
cord-001835-0s7ok4uw	3164	11	the	the	DT
cord-001835-0s7ok4uw	3164	12	tail	tail	NN
cord-001835-0s7ok4uw	3164	13	region	region	NN
cord-001835-0s7ok4uw	3164	14	of	of	IN
cord-001835-0s7ok4uw	3164	15	sperm	sperm	NN
cord-001835-0s7ok4uw	3164	16	.	.	.
cord-001835-0s7ok4uw	3165	1	Each	each	DT
cord-001835-0s7ok4uw	3165	2	subunit	subunit	NN
cord-001835-0s7ok4uw	3165	3	of	of	IN
cord-001835-0s7ok4uw	3165	4	the	the	DT
cord-001835-0s7ok4uw	3165	5	complex	complex	NN
cord-001835-0s7ok4uw	3165	6	contains	contain	VBZ
cord-001835-0s7ok4uw	3165	7	an	an	DT
cord-001835-0s7ok4uw	3165	8	exposed	expose	VBN
cord-001835-0s7ok4uw	3165	9	loop	loop	NN
cord-001835-0s7ok4uw	3165	10	known	know	VBN
cord-001835-0s7ok4uw	3165	11	as	as	IN
cord-001835-0s7ok4uw	3165	12	the	the	DT
cord-001835-0s7ok4uw	3165	13	P	p	NN
cord-001835-0s7ok4uw	3165	14	-	-	HYPH
cord-001835-0s7ok4uw	3165	15	loop	loop	NN
cord-001835-0s7ok4uw	3165	16	.	.	.
cord-001835-0s7ok4uw	3166	1	The	the	DT
cord-001835-0s7ok4uw	3166	2	P	p	NN
cord-001835-0s7ok4uw	3166	3	-	-	HYPH
cord-001835-0s7ok4uw	3166	4	loop	loop	NN
cord-001835-0s7ok4uw	3166	5	is	be	VBZ
cord-001835-0s7ok4uw	3166	6	unique	unique	JJ
cord-001835-0s7ok4uw	3166	7	on	on	IN
cord-001835-0s7ok4uw	3166	8	the	the	DT
cord-001835-0s7ok4uw	3166	9	surface	surface	NN
cord-001835-0s7ok4uw	3166	10	of	of	IN
cord-001835-0s7ok4uw	3166	11	sperm	sperm	NN
cord-001835-0s7ok4uw	3166	12	because	because	IN
cord-001835-0s7ok4uw	3166	13	it	-PRON-	PRP
cord-001835-0s7ok4uw	3166	14	is	be	VBZ
cord-001835-0s7ok4uw	3166	15	not	not	RB
cord-001835-0s7ok4uw	3166	16	glycosylated	glycosylate	VBN
cord-001835-0s7ok4uw	3166	17	,	,	,
cord-001835-0s7ok4uw	3166	18	allowing	allow	VBG
cord-001835-0s7ok4uw	3166	19	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3166	20	to	to	TO
cord-001835-0s7ok4uw	3166	21	potentially	potentially	RB
cord-001835-0s7ok4uw	3166	22	recognize	recognize	VB
cord-001835-0s7ok4uw	3166	23	and	and	CC
cord-001835-0s7ok4uw	3166	24	bind	bind	VB
cord-001835-0s7ok4uw	3166	25	it	-PRON-	PRP
cord-001835-0s7ok4uw	3166	26	.	.	.
cord-001835-0s7ok4uw	3167	1	YLP12	YLP12	NNP
cord-001835-0s7ok4uw	3167	2	is	be	VBZ
cord-001835-0s7ok4uw	3167	3	a	a	DT
cord-001835-0s7ok4uw	3167	4	twelve	twelve	CD
cord-001835-0s7ok4uw	3167	5	residue	residue	NN
cord-001835-0s7ok4uw	3167	6	peptide	peptide	NN
cord-001835-0s7ok4uw	3167	7	that	that	WDT
cord-001835-0s7ok4uw	3167	8	mimics	mimic	VBZ
cord-001835-0s7ok4uw	3167	9	the	the	DT
cord-001835-0s7ok4uw	3167	10	glycans	glycan	NNS
cord-001835-0s7ok4uw	3167	11	in	in	IN
cord-001835-0s7ok4uw	3167	12	the	the	DT
cord-001835-0s7ok4uw	3167	13	glycocalyx	glycocalyx	NNP
cord-001835-0s7ok4uw	3167	14	of	of	IN
cord-001835-0s7ok4uw	3167	15	sperm	sperm	NN
cord-001835-0s7ok4uw	3167	16	.	.	.
cord-001835-0s7ok4uw	3168	1	YLP12	YLP12	NNP
cord-001835-0s7ok4uw	3168	2	is	be	VBZ
cord-001835-0s7ok4uw	3168	3	a	a	DT
cord-001835-0s7ok4uw	3168	4	member	member	NN
cord-001835-0s7ok4uw	3168	5	of	of	IN
cord-001835-0s7ok4uw	3168	6	the	the	DT
cord-001835-0s7ok4uw	3168	7	FliTRX	FliTRX	NNP
cord-001835-0s7ok4uw	3168	8	library	library	NN
cord-001835-0s7ok4uw	3168	9	,	,	,
cord-001835-0s7ok4uw	3168	10	and	and	CC
cord-001835-0s7ok4uw	3168	11	in	in	IN
cord-001835-0s7ok4uw	3168	12	mice	mouse	NNS
cord-001835-0s7ok4uw	3168	13	,	,	,
cord-001835-0s7ok4uw	3168	14	produced	produce	VBD
cord-001835-0s7ok4uw	3168	15	protective	protective	JJ
cord-001835-0s7ok4uw	3168	16	titers	titer	NNS
cord-001835-0s7ok4uw	3168	17	that	that	WDT
cord-001835-0s7ok4uw	3168	18	were	be	VBD
cord-001835-0s7ok4uw	3168	19	reversible	reversible	JJ
cord-001835-0s7ok4uw	3168	20	both	both	CC
cord-001835-0s7ok4uw	3168	21	voluntarily	voluntarily	RB
cord-001835-0s7ok4uw	3168	22	and	and	CC
cord-001835-0s7ok4uw	3168	23	involuntarily	involuntarily	RB
cord-001835-0s7ok4uw	3168	24	.	.	.
cord-001835-0s7ok4uw	3169	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3169	2	designs	design	NNS
cord-001835-0s7ok4uw	3169	3	will	will	MD
cord-001835-0s7ok4uw	3169	4	introduce	introduce	VB
cord-001835-0s7ok4uw	3169	5	these	these	DT
cord-001835-0s7ok4uw	3169	6	two	two	CD
cord-001835-0s7ok4uw	3169	7	potential	potential	JJ
cord-001835-0s7ok4uw	3169	8	antigens	antigen	NNS
cord-001835-0s7ok4uw	3169	9	into	into	IN
cord-001835-0s7ok4uw	3169	10	a	a	DT
cord-001835-0s7ok4uw	3169	11	loop	loop	NN
cord-001835-0s7ok4uw	3169	12	of	of	IN
cord-001835-0s7ok4uw	3169	13	the	the	DT
cord-001835-0s7ok4uw	3169	14	L1	L1	NNP
cord-001835-0s7ok4uw	3169	15	protein	protein	NN
cord-001835-0s7ok4uw	3169	16	of	of	IN
cord-001835-0s7ok4uw	3169	17	Human	Human	NNP
cord-001835-0s7ok4uw	3169	18	Papilloma	Papilloma	NNP
cord-001835-0s7ok4uw	3169	19	Virus	Virus	NNP
cord-001835-0s7ok4uw	3169	20	.	.	.
cord-001835-0s7ok4uw	3170	1	L1	L1	NNP
cord-001835-0s7ok4uw	3170	2	spontaneously	spontaneously	RB
cord-001835-0s7ok4uw	3170	3	assembles	assemble	VBZ
cord-001835-0s7ok4uw	3170	4	into	into	IN
cord-001835-0s7ok4uw	3170	5	virus	virus	NN
cord-001835-0s7ok4uw	3170	6	like	like	IN
cord-001835-0s7ok4uw	3170	7	particles	particle	NNS
cord-001835-0s7ok4uw	3170	8	,	,	,
cord-001835-0s7ok4uw	3170	9	and	and	CC
cord-001835-0s7ok4uw	3170	10	will	will	MD
cord-001835-0s7ok4uw	3170	11	aid	aid	VB
cord-001835-0s7ok4uw	3170	12	in	in	IN
cord-001835-0s7ok4uw	3170	13	the	the	DT
cord-001835-0s7ok4uw	3170	14	production	production	NN
cord-001835-0s7ok4uw	3170	15	of	of	IN
cord-001835-0s7ok4uw	3170	16	a	a	DT
cord-001835-0s7ok4uw	3170	17	robust	robust	JJ
cord-001835-0s7ok4uw	3170	18	immune	immune	JJ
cord-001835-0s7ok4uw	3170	19	response	response	NN
cord-001835-0s7ok4uw	3170	20	.	.	.
cord-001835-0s7ok4uw	3171	1	Protein	protein	NN
cord-001835-0s7ok4uw	3171	2	carriers	carrier	NNS
cord-001835-0s7ok4uw	3171	3	for	for	IN
cord-001835-0s7ok4uw	3171	4	passage	passage	NN
cord-001835-0s7ok4uw	3171	5	of	of	IN
cord-001835-0s7ok4uw	3171	6	the	the	DT
cord-001835-0s7ok4uw	3171	7	Blood	Blood	NNP
cord-001835-0s7ok4uw	3171	8	-	-	HYPH
cord-001835-0s7ok4uw	3171	9	Brain	Brain	NNP
cord-001835-0s7ok4uw	3171	10	Barrier	Barrier	NNP
cord-001835-0s7ok4uw	3171	11	Sinisa	Sinisa	NNP
cord-001835-0s7ok4uw	3171	12	Bjelic	Bjelic	NNP
cord-001835-0s7ok4uw	3171	13	1	1	CD
cord-001835-0s7ok4uw	3171	14	1	1	CD
cord-001835-0s7ok4uw	3171	15	Medical	medical	JJ
cord-001835-0s7ok4uw	3171	16	solutions	solution	NNS
cord-001835-0s7ok4uw	3171	17	that	that	WDT
cord-001835-0s7ok4uw	3171	18	help	help	VBP
cord-001835-0s7ok4uw	3171	19	protein	protein	NN
cord-001835-0s7ok4uw	3171	20	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	3171	21	accumulate	accumulate	VB
cord-001835-0s7ok4uw	3171	22	into	into	IN
cord-001835-0s7ok4uw	3171	23	the	the	DT
cord-001835-0s7ok4uw	3171	24	brain	brain	NN
cord-001835-0s7ok4uw	3171	25	are	be	VBP
cord-001835-0s7ok4uw	3171	26	crucial	crucial	JJ
cord-001835-0s7ok4uw	3171	27	for	for	IN
cord-001835-0s7ok4uw	3171	28	future	future	JJ
cord-001835-0s7ok4uw	3171	29	treatment	treatment	NN
cord-001835-0s7ok4uw	3171	30	of	of	IN
cord-001835-0s7ok4uw	3171	31	neurological	neurological	JJ
cord-001835-0s7ok4uw	3171	32	disorders	disorder	NNS
cord-001835-0s7ok4uw	3171	33	.	.	.
cord-001835-0s7ok4uw	3172	1	Biodrugs	biodrug	NNS
cord-001835-0s7ok4uw	3172	2	have	have	VBP
cord-001835-0s7ok4uw	3172	3	a	a	DT
cord-001835-0s7ok4uw	3172	4	tremendous	tremendous	JJ
cord-001835-0s7ok4uw	3172	5	potential	potential	NN
cord-001835-0s7ok4uw	3172	6	to	to	TO
cord-001835-0s7ok4uw	3172	7	treat	treat	VB
cord-001835-0s7ok4uw	3172	8	disorders	disorder	NNS
cord-001835-0s7ok4uw	3172	9	of	of	IN
cord-001835-0s7ok4uw	3172	10	the	the	DT
cord-001835-0s7ok4uw	3172	11	nervous	nervous	JJ
cord-001835-0s7ok4uw	3172	12	system	system	NN
cord-001835-0s7ok4uw	3172	13	,	,	,
cord-001835-0s7ok4uw	3172	14	but	but	CC
cord-001835-0s7ok4uw	3172	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3172	16	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3172	17	has	have	VBZ
cord-001835-0s7ok4uw	3172	18	been	be	VBN
cord-001835-0s7ok4uw	3172	19	severely	severely	RB
cord-001835-0s7ok4uw	3172	20	restricted	restrict	VBN
cord-001835-0s7ok4uw	3172	21	.	.	.
cord-001835-0s7ok4uw	3173	1	To	to	TO
cord-001835-0s7ok4uw	3173	2	reach	reach	VB
cord-001835-0s7ok4uw	3173	3	the	the	DT
cord-001835-0s7ok4uw	3173	4	brain	brain	NN
cord-001835-0s7ok4uw	3173	5	all	all	DT
cord-001835-0s7ok4uw	3173	6	drugs	drug	NNS
cord-001835-0s7ok4uw	3173	7	must	must	MD
cord-001835-0s7ok4uw	3173	8	traverse	traverse	VB
cord-001835-0s7ok4uw	3173	9	the	the	DT
cord-001835-0s7ok4uw	3173	10	blood	blood	NN
cord-001835-0s7ok4uw	3173	11	-	-	HYPH
cord-001835-0s7ok4uw	3173	12	brain	brain	NN
cord-001835-0s7ok4uw	3173	13	barrier	barrier	NN
cord-001835-0s7ok4uw	3173	14	(	(	-LRB-
cord-001835-0s7ok4uw	3173	15	BBB	BBB	NNP
cord-001835-0s7ok4uw	3173	16	)	)	-RRB-
cord-001835-0s7ok4uw	3173	17	-a	-a	HYPH
cord-001835-0s7ok4uw	3173	18	permeable	permeable	JJ
cord-001835-0s7ok4uw	3173	19	wall	wall	NN
cord-001835-0s7ok4uw	3173	20	that	that	WDT
cord-001835-0s7ok4uw	3173	21	separates	separate	VBZ
cord-001835-0s7ok4uw	3173	22	blood	blood	NN
cord-001835-0s7ok4uw	3173	23	from	from	IN
cord-001835-0s7ok4uw	3173	24	the	the	DT
cord-001835-0s7ok4uw	3173	25	brain	brain	NN
cord-001835-0s7ok4uw	3174	1	-whose	-whose	.
cord-001835-0s7ok4uw	3175	1	main	main	JJ
cord-001835-0s7ok4uw	3175	2	function	function	NN
cord-001835-0s7ok4uw	3175	3	is	be	VBZ
cord-001835-0s7ok4uw	3175	4	to	to	TO
cord-001835-0s7ok4uw	3175	5	protect	protect	VB
cord-001835-0s7ok4uw	3175	6	the	the	DT
cord-001835-0s7ok4uw	3175	7	nervous	nervous	JJ
cord-001835-0s7ok4uw	3175	8	system	system	NN
cord-001835-0s7ok4uw	3175	9	from	from	IN
cord-001835-0s7ok4uw	3175	10	environmental	environmental	JJ
cord-001835-0s7ok4uw	3175	11	influences	influence	NNS
cord-001835-0s7ok4uw	3175	12	of	of	IN
cord-001835-0s7ok4uw	3175	13	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	3175	14	and	and	CC
cord-001835-0s7ok4uw	3175	15	toxins	toxin	NNS
cord-001835-0s7ok4uw	3175	16	.	.	.
cord-001835-0s7ok4uw	3176	1	Unfortunately	unfortunately	RB
cord-001835-0s7ok4uw	3176	2	the	the	DT
cord-001835-0s7ok4uw	3176	3	BBB	BBB	NNP
cord-001835-0s7ok4uw	3176	4	is	be	VBZ
cord-001835-0s7ok4uw	3176	5	also	also	RB
cord-001835-0s7ok4uw	3176	6	the	the	DT
cord-001835-0s7ok4uw	3176	7	culprit	culprit	NN
cord-001835-0s7ok4uw	3176	8	that	that	WDT
cord-001835-0s7ok4uw	3176	9	effectively	effectively	RB
cord-001835-0s7ok4uw	3176	10	blocks	block	VBZ
cord-001835-0s7ok4uw	3176	11	access	access	NN
cord-001835-0s7ok4uw	3176	12	to	to	IN
cord-001835-0s7ok4uw	3176	13	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	3176	14	required	require	VBN
cord-001835-0s7ok4uw	3176	15	for	for	IN
cord-001835-0s7ok4uw	3176	16	treatment	treatment	NN
cord-001835-0s7ok4uw	3176	17	of	of	IN
cord-001835-0s7ok4uw	3176	18	neurological	neurological	JJ
cord-001835-0s7ok4uw	3176	19	diseases	disease	NNS
cord-001835-0s7ok4uw	3176	20	.	.	.
cord-001835-0s7ok4uw	3177	1	A	a	DT
cord-001835-0s7ok4uw	3177	2	way	way	NN
cord-001835-0s7ok4uw	3177	3	to	to	TO
cord-001835-0s7ok4uw	3177	4	boost	boost	VB
cord-001835-0s7ok4uw	3177	5	exposure	exposure	NN
cord-001835-0s7ok4uw	3177	6	of	of	IN
cord-001835-0s7ok4uw	3177	7	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	3177	8	across	across	IN
cord-001835-0s7ok4uw	3177	9	the	the	DT
cord-001835-0s7ok4uw	3177	10	BBB	BBB	NNP
cord-001835-0s7ok4uw	3177	11	is	be	VBZ
cord-001835-0s7ok4uw	3177	12	to	to	TO
cord-001835-0s7ok4uw	3177	13	piggyback	piggyback	VB
cord-001835-0s7ok4uw	3177	14	onto	onto	IN
cord-001835-0s7ok4uw	3177	15	the	the	DT
cord-001835-0s7ok4uw	3177	16	transferrin	transferrin	NN
cord-001835-0s7ok4uw	3177	17	receptor	receptor	NN
cord-001835-0s7ok4uw	3177	18	,	,	,
cord-001835-0s7ok4uw	3177	19	a	a	DT
cord-001835-0s7ok4uw	3177	20	multidomain	multidomain	NN
cord-001835-0s7ok4uw	3177	21	protein	protein	NN
cord-001835-0s7ok4uw	3177	22	anchored	anchor	VBN
cord-001835-0s7ok4uw	3177	23	in	in	IN
cord-001835-0s7ok4uw	3177	24	the	the	DT
cord-001835-0s7ok4uw	3177	25	membrane	membrane	NN
cord-001835-0s7ok4uw	3177	26	,	,	,
cord-001835-0s7ok4uw	3177	27	which	which	WDT
cord-001835-0s7ok4uw	3177	28	is	be	VBZ
cord-001835-0s7ok4uw	3177	29	involved	involve	VBN
cord-001835-0s7ok4uw	3177	30	in	in	IN
cord-001835-0s7ok4uw	3177	31	the	the	DT
cord-001835-0s7ok4uw	3177	32	physiological	physiological	JJ
cord-001835-0s7ok4uw	3177	33	facilitation	facilitation	NN
cord-001835-0s7ok4uw	3177	34	of	of	IN
cord-001835-0s7ok4uw	3177	35	iron	iron	NN
cord-001835-0s7ok4uw	3177	36	uptake	uptake	NN
cord-001835-0s7ok4uw	3177	37	.	.	.
cord-001835-0s7ok4uw	3178	1	Here	here	RB
cord-001835-0s7ok4uw	3178	2	I	-PRON-	PRP
cord-001835-0s7ok4uw	3178	3	present	present	VBP
cord-001835-0s7ok4uw	3178	4	research	research	NN
cord-001835-0s7ok4uw	3178	5	that	that	WDT
cord-001835-0s7ok4uw	3178	6	aims	aim	VBZ
cord-001835-0s7ok4uw	3178	7	at	at	IN
cord-001835-0s7ok4uw	3178	8	successfully	successfully	RB
cord-001835-0s7ok4uw	3178	9	developing	develop	VBG
cord-001835-0s7ok4uw	3178	10	potent	potent	JJ
cord-001835-0s7ok4uw	3178	11	protein	protein	NN
cord-001835-0s7ok4uw	3178	12	carriers	carrier	NNS
cord-001835-0s7ok4uw	3178	13	for	for	IN
cord-001835-0s7ok4uw	3178	14	transferrin	transferrin	NN
cord-001835-0s7ok4uw	3178	15	receptor	receptor	NN
cord-001835-0s7ok4uw	3178	16	-	-	HYPH
cord-001835-0s7ok4uw	3178	17	mediated	mediate	VBN
cord-001835-0s7ok4uw	3178	18	passage	passage	NN
cord-001835-0s7ok4uw	3178	19	of	of	IN
cord-001835-0s7ok4uw	3178	20	the	the	DT
cord-001835-0s7ok4uw	3178	21	BBB	BBB	NNP
cord-001835-0s7ok4uw	3178	22	by	by	IN
cord-001835-0s7ok4uw	3178	23	using	use	VBG
cord-001835-0s7ok4uw	3178	24	computational	computational	JJ
cord-001835-0s7ok4uw	3178	25	protein	protein	NN
cord-001835-0s7ok4uw	3178	26	design	design	NN
cord-001835-0s7ok4uw	3178	27	in	in	IN
cord-001835-0s7ok4uw	3178	28	combination	combination	NN
cord-001835-0s7ok4uw	3178	29	with	with	IN
cord-001835-0s7ok4uw	3178	30	yeast	yeast	NN
cord-001835-0s7ok4uw	3178	31	display	display	NN
cord-001835-0s7ok4uw	3178	32	methodology	methodology	NN
cord-001835-0s7ok4uw	3178	33	for	for	IN
cord-001835-0s7ok4uw	3178	34	hit	hit	NN
cord-001835-0s7ok4uw	3178	35	validation	validation	NN
cord-001835-0s7ok4uw	3178	36	and	and	CC
cord-001835-0s7ok4uw	3178	37	optimization	optimization	NN
cord-001835-0s7ok4uw	3178	38	.	.	.
cord-001835-0s7ok4uw	3179	1	The	the	DT
cord-001835-0s7ok4uw	3179	2	longterm	longterm	JJ
cord-001835-0s7ok4uw	3179	3	goal	goal	NN
cord-001835-0s7ok4uw	3179	4	is	be	VBZ
cord-001835-0s7ok4uw	3179	5	to	to	IN
cord-001835-0s7ok4uw	3179	6	couple	couple	NN
cord-001835-0s7ok4uw	3179	7	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	3179	8	-as	-as	NFP
cord-001835-0s7ok4uw	3179	9	for	for	IN
cord-001835-0s7ok4uw	3179	10	example	example	NN
cord-001835-0s7ok4uw	3179	11	drugs	drug	NNS
cord-001835-0s7ok4uw	3179	12	against	against	IN
cord-001835-0s7ok4uw	3179	13	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	3179	14	's	's	POS
cord-001835-0s7ok4uw	3179	15	-to	-to	:
cord-001835-0s7ok4uw	3179	16	the	the	DT
cord-001835-0s7ok4uw	3179	17	designed	design	VBN
cord-001835-0s7ok4uw	3179	18	carriers	carrier	NNS
cord-001835-0s7ok4uw	3179	19	to	to	TO
cord-001835-0s7ok4uw	3179	20	increase	increase	VB
cord-001835-0s7ok4uw	3179	21	the	the	DT
cord-001835-0s7ok4uw	3179	22	brain	brain	NN
cord-001835-0s7ok4uw	3179	23	uptake	uptake	NN
cord-001835-0s7ok4uw	3179	24	and	and	CC
cord-001835-0s7ok4uw	3179	25	cure	cure	VB
cord-001835-0s7ok4uw	3179	26	neurological	neurological	JJ
cord-001835-0s7ok4uw	3179	27	disorders	disorder	NNS
cord-001835-0s7ok4uw	3179	28	.	.	.
cord-001835-0s7ok4uw	3180	1	Medium	medium	NN
cord-001835-0s7ok4uw	3180	2	-	-	HYPH
cord-001835-0s7ok4uw	3180	3	throughput	throughput	NN
cord-001835-0s7ok4uw	3180	4	multistep	multistep	NN
cord-001835-0s7ok4uw	3180	5	purification	purification	NN
cord-001835-0s7ok4uw	3180	6	of	of	IN
cord-001835-0s7ok4uw	3180	7	coagulation	coagulation	NN
cord-001835-0s7ok4uw	3180	8	factor	factor	NN
cord-001835-0s7ok4uw	3180	9	VIIa	VIIa	NNS
cord-001835-0s7ok4uw	3181	1	Jais	Jais	NNP
cord-001835-0s7ok4uw	3181	2	R.	R.	NNP
cord-001835-0s7ok4uw	3181	3	Bjelke	Bjelke	NNP
cord-001835-0s7ok4uw	3181	4	1	1	CD
cord-001835-0s7ok4uw	3181	5	,	,	,
cord-001835-0s7ok4uw	3181	6	Gorm	Gorm	NNP
cord-001835-0s7ok4uw	3181	7	Andersen	Andersen	NNP
cord-001835-0s7ok4uw	3181	8	1	1	CD
cord-001835-0s7ok4uw	3181	9	,	,	,
cord-001835-0s7ok4uw	3181	10	Henrik	Henrik	NNP
cord-001835-0s7ok4uw	3181	11	Østergaard	Østergaard	NNP
cord-001835-0s7ok4uw	3181	12	1	1	CD
cord-001835-0s7ok4uw	3181	13	,	,	,
cord-001835-0s7ok4uw	3181	14	Laust	Laust	NNP
cord-001835-0s7ok4uw	3181	15	B.	B.	NNP
cord-001835-0s7ok4uw	3181	16	Johnsen	Johnsen	NNP
cord-001835-0s7ok4uw	3181	17	1	1	CD
cord-001835-0s7ok4uw	3181	18	,	,	,
cord-001835-0s7ok4uw	3181	19	Anette	Anette	NNP
cord-001835-0s7ok4uw	3181	20	A.	a.	NN
cord-001835-0s7ok4uw	3181	21	Pedersen	Pedersen	NNP
cord-001835-0s7ok4uw	3181	22	1	1	CD
cord-001835-0s7ok4uw	3181	23	,	,	,
cord-001835-0s7ok4uw	3181	24	Tina	Tina	NNP
cord-001835-0s7ok4uw	3181	25	H.	H.	NNP
cord-001835-0s7ok4uw	3181	26	Glue	Glue	NNP
cord-001835-0s7ok4uw	3181	27	1	1	CD
cord-001835-0s7ok4uw	3181	28	1	1	CD
cord-001835-0s7ok4uw	3182	1	There	there	EX
cord-001835-0s7ok4uw	3182	2	is	be	VBZ
cord-001835-0s7ok4uw	3182	3	a	a	DT
cord-001835-0s7ok4uw	3182	4	need	need	NN
cord-001835-0s7ok4uw	3182	5	of	of	IN
cord-001835-0s7ok4uw	3182	6	medium	medium	NN
cord-001835-0s7ok4uw	3182	7	-	-	HYPH
cord-001835-0s7ok4uw	3182	8	to	to	IN
cord-001835-0s7ok4uw	3182	9	-	-	HYPH
cord-001835-0s7ok4uw	3182	10	high	high	JJ
cord-001835-0s7ok4uw	3182	11	throughput	throughput	NN
cord-001835-0s7ok4uw	3182	12	purification	purification	NN
cord-001835-0s7ok4uw	3182	13	of	of	IN
cord-001835-0s7ok4uw	3182	14	low	low	JJ
cord-001835-0s7ok4uw	3182	15	-	-	HYPH
cord-001835-0s7ok4uw	3182	16	titre	titre	NN
cord-001835-0s7ok4uw	3182	17	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	3182	18	protein	protein	NN
cord-001835-0s7ok4uw	3182	19	variants	variant	NNS
cord-001835-0s7ok4uw	3182	20	for	for	IN
cord-001835-0s7ok4uw	3182	21	screening	screening	NN
cord-001835-0s7ok4uw	3182	22	to	to	TO
cord-001835-0s7ok4uw	3182	23	identify	identify	VB
cord-001835-0s7ok4uw	3182	24	the	the	DT
cord-001835-0s7ok4uw	3182	25	final	final	JJ
cord-001835-0s7ok4uw	3182	26	biopharmaceutical	biopharmaceutical	JJ
cord-001835-0s7ok4uw	3182	27	lead	lead	NN
cord-001835-0s7ok4uw	3182	28	.	.	.
cord-001835-0s7ok4uw	3183	1	Such	such	JJ
cord-001835-0s7ok4uw	3183	2	proteins	protein	NNS
cord-001835-0s7ok4uw	3183	3	include	include	VBP
cord-001835-0s7ok4uw	3183	4	coagulation	coagulation	NN
cord-001835-0s7ok4uw	3183	5	factors	factor	NNS
cord-001835-0s7ok4uw	3183	6	to	to	TO
cord-001835-0s7ok4uw	3183	7	be	be	VB
cord-001835-0s7ok4uw	3183	8	used	use	VBN
cord-001835-0s7ok4uw	3183	9	for	for	IN
cord-001835-0s7ok4uw	3183	10	treatment	treatment	NN
cord-001835-0s7ok4uw	3183	11	of	of	IN
cord-001835-0s7ok4uw	3183	12	haemophilia	haemophilia	NN
cord-001835-0s7ok4uw	3183	13	and	and	CC
cord-001835-0s7ok4uw	3183	14	other	other	JJ
cord-001835-0s7ok4uw	3183	15	bleeding	bleed	VBG
cord-001835-0s7ok4uw	3183	16	disorders	disorder	NNS
cord-001835-0s7ok4uw	3183	17	.	.	.
cord-001835-0s7ok4uw	3184	1	At	at	IN
cord-001835-0s7ok4uw	3184	2	Novo	Novo	NNP
cord-001835-0s7ok4uw	3184	3	Nordisk	Nordisk	NNP
cord-001835-0s7ok4uw	3184	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3184	5	have	have	VBP
cord-001835-0s7ok4uw	3184	6	established	establish	VBN
cord-001835-0s7ok4uw	3184	7	a	a	DT
cord-001835-0s7ok4uw	3184	8	platform	platform	NN
cord-001835-0s7ok4uw	3184	9	for	for	IN
cord-001835-0s7ok4uw	3184	10	production	production	NN
cord-001835-0s7ok4uw	3184	11	of	of	IN
cord-001835-0s7ok4uw	3184	12	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	3184	13	coagulation	coagulation	NN
cord-001835-0s7ok4uw	3184	14	factor	factor	NN
cord-001835-0s7ok4uw	3184	15	VIIa	VIIa	NNS
cord-001835-0s7ok4uw	3184	16	variants	variant	NNS
cord-001835-0s7ok4uw	3184	17	,	,	,
cord-001835-0s7ok4uw	3184	18	which	which	WDT
cord-001835-0s7ok4uw	3184	19	include	include	VBP
cord-001835-0s7ok4uw	3184	20	a	a	DT
cord-001835-0s7ok4uw	3184	21	spectrum	spectrum	NN
cord-001835-0s7ok4uw	3184	22	of	of	IN
cord-001835-0s7ok4uw	3184	23	single	single	JJ
cord-001835-0s7ok4uw	3184	24	-	-	HYPH
cord-001835-0s7ok4uw	3184	25	point	point	NN
cord-001835-0s7ok4uw	3184	26	mutations	mutation	NNS
cord-001835-0s7ok4uw	3184	27	to	to	IN
cord-001835-0s7ok4uw	3184	28	large	large	JJ
cord-001835-0s7ok4uw	3184	29	domain	domain	NN
cord-001835-0s7ok4uw	3184	30	insertions	insertion	NNS
cord-001835-0s7ok4uw	3184	31	.	.	.
cord-001835-0s7ok4uw	3185	1	The	the	DT
cord-001835-0s7ok4uw	3185	2	variants	variant	NNS
cord-001835-0s7ok4uw	3185	3	were	be	VBD
cord-001835-0s7ok4uw	3185	4	produced	produce	VBN
cord-001835-0s7ok4uw	3185	5	using	use	VBG
cord-001835-0s7ok4uw	3185	6	transiently	transiently	RB
cord-001835-0s7ok4uw	3185	7	transfected	transfecte	VBN
cord-001835-0s7ok4uw	3185	8	HEK293F	HEK293F	NNP
cord-001835-0s7ok4uw	3185	9	,	,	,
cord-001835-0s7ok4uw	3185	10	HKB11	HKB11	NNP
cord-001835-0s7ok4uw	3185	11	or	or	CC
cord-001835-0s7ok4uw	3185	12	CHOEBNALT85	CHOEBNALT85	NNP
cord-001835-0s7ok4uw	3185	13	(	(	-LRB-
cord-001835-0s7ok4uw	3185	14	QMCF	QMCF	NNP
cord-001835-0s7ok4uw	3185	15	Technology	Technology	NNP
cord-001835-0s7ok4uw	3185	16	)	)	-RRB-
cord-001835-0s7ok4uw	3185	17	suspension	suspension	NN
cord-001835-0s7ok4uw	3185	18	cells	cell	NNS
cord-001835-0s7ok4uw	3185	19	.	.	.
cord-001835-0s7ok4uw	3186	1	Harvest	harvest	NN
cord-001835-0s7ok4uw	3186	2	cultivations	cultivation	NNS
cord-001835-0s7ok4uw	3186	3	were	be	VBD
cord-001835-0s7ok4uw	3186	4	typical	typical	JJ
cord-001835-0s7ok4uw	3186	5	in	in	IN
cord-001835-0s7ok4uw	3186	6	the	the	DT
cord-001835-0s7ok4uw	3186	7	range	range	NN
cord-001835-0s7ok4uw	3186	8	of	of	IN
cord-001835-0s7ok4uw	3186	9	0.3-to	0.3-to	CD
cord-001835-0s7ok4uw	3186	10	1L.	1l.	CD
cord-001835-0s7ok4uw	3186	11	A	a	DT
cord-001835-0s7ok4uw	3186	12	3-step	3-step	NNP
cord-001835-0s7ok4uw	3186	13	continuous	continuous	JJ
cord-001835-0s7ok4uw	3186	14	,	,	,
cord-001835-0s7ok4uw	3186	15	multistep	multistep	JJ
cord-001835-0s7ok4uw	3186	16	purification	purification	NN
cord-001835-0s7ok4uw	3186	17	method	method	NN
cord-001835-0s7ok4uw	3186	18	was	be	VBD
cord-001835-0s7ok4uw	3186	19	implemented	implement	VBN
cord-001835-0s7ok4uw	3186	20	on	on	IN
cord-001835-0s7ok4uw	3186	21	€	€	$
cord-001835-0s7ok4uw	3186	22	AKTAxpress	aktaxpress	NN
cord-001835-0s7ok4uw	3186	23	systems	system	NNS
cord-001835-0s7ok4uw	3186	24	(	(	-LRB-
cord-001835-0s7ok4uw	3186	25	GE	GE	NNP
cord-001835-0s7ok4uw	3186	26	Healthcare	Healthcare	NNP
cord-001835-0s7ok4uw	3186	27	)	)	-RRB-
cord-001835-0s7ok4uw	3186	28	.	.	.
cord-001835-0s7ok4uw	3187	1	The	the	DT
cord-001835-0s7ok4uw	3187	2	interlinked	interlinked	JJ
cord-001835-0s7ok4uw	3187	3	process	process	NN
cord-001835-0s7ok4uw	3187	4	steps	step	NNS
cord-001835-0s7ok4uw	3187	5	include	include	VBP
cord-001835-0s7ok4uw	3187	6	capture	capture	NN
cord-001835-0s7ok4uw	3187	7	using	use	VBG
cord-001835-0s7ok4uw	3187	8	an	an	DT
cord-001835-0s7ok4uw	3187	9	immunoaffinity	immunoaffinity	NN
cord-001835-0s7ok4uw	3187	10	column	column	NN
cord-001835-0s7ok4uw	3187	11	,	,	,
cord-001835-0s7ok4uw	3187	12	polish	polish	NN
cord-001835-0s7ok4uw	3187	13	,	,	,
cord-001835-0s7ok4uw	3187	14	concentration	concentration	NN
cord-001835-0s7ok4uw	3187	15	and	and	CC
cord-001835-0s7ok4uw	3187	16	buffer	buffer	NN
cord-001835-0s7ok4uw	3187	17	exchange	exchange	NN
cord-001835-0s7ok4uw	3187	18	using	use	VBG
cord-001835-0s7ok4uw	3187	19	an	an	DT
cord-001835-0s7ok4uw	3187	20	anion	anion	NN
cord-001835-0s7ok4uw	3187	21	-	-	HYPH
cord-001835-0s7ok4uw	3187	22	exchange	exchange	NN
cord-001835-0s7ok4uw	3187	23	column	column	NN
cord-001835-0s7ok4uw	3187	24	and	and	CC
cord-001835-0s7ok4uw	3187	25	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	3187	26	activation	activation	NN
cord-001835-0s7ok4uw	3187	27	of	of	IN
cord-001835-0s7ok4uw	3187	28	the	the	DT
cord-001835-0s7ok4uw	3187	29	zymogen	zymogen	NNP
cord-001835-0s7ok4uw	3187	30	variant	variant	NN
cord-001835-0s7ok4uw	3187	31	forms	form	NNS
cord-001835-0s7ok4uw	3187	32	using	use	VBG
cord-001835-0s7ok4uw	3187	33	a	a	DT
cord-001835-0s7ok4uw	3187	34	coagulation	coagulation	NN
cord-001835-0s7ok4uw	3187	35	factor	factor	NN
cord-001835-0s7ok4uw	3188	1	Xaimmobilized	xaimmobilized	JJ
cord-001835-0s7ok4uw	3188	2	column	column	NN
cord-001835-0s7ok4uw	3188	3	.	.	.
cord-001835-0s7ok4uw	3189	1	Buffers	buffer	NNS
cord-001835-0s7ok4uw	3189	2	were	be	VBD
cord-001835-0s7ok4uw	3189	3	designed	design	VBN
cord-001835-0s7ok4uw	3189	4	such	such	PDT
cord-001835-0s7ok4uw	3189	5	that	that	DT
cord-001835-0s7ok4uw	3189	6	elution	elution	NN
cord-001835-0s7ok4uw	3189	7	from	from	IN
cord-001835-0s7ok4uw	3189	8	the	the	DT
cord-001835-0s7ok4uw	3189	9	capture	capture	NN
cord-001835-0s7ok4uw	3189	10	column	column	NN
cord-001835-0s7ok4uw	3189	11	was	be	VBD
cord-001835-0s7ok4uw	3189	12	aligned	align	VBN
cord-001835-0s7ok4uw	3189	13	with	with	IN
cord-001835-0s7ok4uw	3189	14	binding	bind	VBG
cord-001835-0s7ok4uw	3189	15	conditions	condition	NNS
cord-001835-0s7ok4uw	3189	16	on	on	IN
cord-001835-0s7ok4uw	3189	17	the	the	DT
cord-001835-0s7ok4uw	3189	18	polish	polish	JJ
cord-001835-0s7ok4uw	3189	19	column	column	NN
cord-001835-0s7ok4uw	3189	20	to	to	TO
cord-001835-0s7ok4uw	3189	21	avoid	avoid	VB
cord-001835-0s7ok4uw	3189	22	a	a	DT
cord-001835-0s7ok4uw	3189	23	desalting	desalting	NN
cord-001835-0s7ok4uw	3189	24	step	step	NN
cord-001835-0s7ok4uw	3189	25	in	in	IN
cord-001835-0s7ok4uw	3189	26	-	-	HYPH
cord-001835-0s7ok4uw	3189	27	between	between	NN
cord-001835-0s7ok4uw	3189	28	.	.	.
cord-001835-0s7ok4uw	3190	1	The	the	DT
cord-001835-0s7ok4uw	3190	2	following	following	JJ
cord-001835-0s7ok4uw	3190	3	and	and	CC
cord-001835-0s7ok4uw	3190	4	final	final	JJ
cord-001835-0s7ok4uw	3190	5	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	3190	6	activation	activation	NN
cord-001835-0s7ok4uw	3190	7	was	be	VBD
cord-001835-0s7ok4uw	3190	8	optimized	optimize	VBN
cord-001835-0s7ok4uw	3190	9	with	with	IN
cord-001835-0s7ok4uw	3190	10	regards	regard	NNS
cord-001835-0s7ok4uw	3190	11	to	to	IN
cord-001835-0s7ok4uw	3190	12	flow	flow	NN
cord-001835-0s7ok4uw	3190	13	rate	rate	NN
cord-001835-0s7ok4uw	3190	14	to	to	TO
cord-001835-0s7ok4uw	3190	15	ensure	ensure	VB
cord-001835-0s7ok4uw	3190	16	full	full	JJ
cord-001835-0s7ok4uw	3190	17	conversion	conversion	NN
cord-001835-0s7ok4uw	3190	18	while	while	IN
cord-001835-0s7ok4uw	3190	19	minimizing	minimize	VBG
cord-001835-0s7ok4uw	3190	20	unwanted	unwanted	JJ
cord-001835-0s7ok4uw	3190	21	secondary	secondary	JJ
cord-001835-0s7ok4uw	3190	22	cleavages	cleavage	NNS
cord-001835-0s7ok4uw	3190	23	in	in	IN
cord-001835-0s7ok4uw	3190	24	factor	factor	NN
cord-001835-0s7ok4uw	3190	25	VIIa	VIIa	NNS
cord-001835-0s7ok4uw	3190	26	.	.	.
cord-001835-0s7ok4uw	3191	1	The	the	DT
cord-001835-0s7ok4uw	3191	2	final	final	JJ
cord-001835-0s7ok4uw	3191	3	products	product	NNS
cord-001835-0s7ok4uw	3191	4	were	be	VBD
cord-001835-0s7ok4uw	3191	5	fractionated	fractionate	VBN
cord-001835-0s7ok4uw	3191	6	in	in	IN
cord-001835-0s7ok4uw	3191	7	sharp	sharp	JJ
cord-001835-0s7ok4uw	3191	8	chromatographic	chromatographic	JJ
cord-001835-0s7ok4uw	3191	9	peaks	peak	NNS
cord-001835-0s7ok4uw	3191	10	ready	ready	JJ
cord-001835-0s7ok4uw	3191	11	for	for	IN
cord-001835-0s7ok4uw	3191	12	characterization	characterization	NN
cord-001835-0s7ok4uw	3191	13	.	.	.
cord-001835-0s7ok4uw	3192	1	HPLC	HPLC	NNP
cord-001835-0s7ok4uw	3192	2	and	and	CC
cord-001835-0s7ok4uw	3192	3	SDS	SDS	NNP
cord-001835-0s7ok4uw	3192	4	-	-	HYPH
cord-001835-0s7ok4uw	3192	5	PAGE	page	NN
cord-001835-0s7ok4uw	3192	6	analyses	analysis	NNS
cord-001835-0s7ok4uw	3192	7	showed	show	VBD
cord-001835-0s7ok4uw	3192	8	a	a	DT
cord-001835-0s7ok4uw	3192	9	solid	solid	JJ
cord-001835-0s7ok4uw	3192	10	quality	quality	NN
cord-001835-0s7ok4uw	3192	11	of	of	IN
cord-001835-0s7ok4uw	3192	12	the	the	DT
cord-001835-0s7ok4uw	3192	13	produced	produce	VBN
cord-001835-0s7ok4uw	3192	14	variants	variant	NNS
cord-001835-0s7ok4uw	3192	15	and	and	CC
cord-001835-0s7ok4uw	3192	16	more	more	JJR
cord-001835-0s7ok4uw	3192	17	than	than	IN
cord-001835-0s7ok4uw	3192	18	800	800	CD
cord-001835-0s7ok4uw	3192	19	variants	variant	NNS
cord-001835-0s7ok4uw	3192	20	have	have	VBP
cord-001835-0s7ok4uw	3192	21	been	be	VBN
cord-001835-0s7ok4uw	3192	22	produced	produce	VBN
cord-001835-0s7ok4uw	3192	23	in	in	IN
cord-001835-0s7ok4uw	3192	24	sub	sub	NN
cord-001835-0s7ok4uw	3192	25	mg	mg	NNP
cord-001835-0s7ok4uw	3192	26	scale	scale	NN
cord-001835-0s7ok4uw	3192	27	using	use	VBG
cord-001835-0s7ok4uw	3192	28	the	the	DT
cord-001835-0s7ok4uw	3192	29	outlined	outline	VBN
cord-001835-0s7ok4uw	3192	30	method	method	NN
cord-001835-0s7ok4uw	3192	31	.	.	.
cord-001835-0s7ok4uw	3193	1	Biomimetic	Biomimetic	NNP
cord-001835-0s7ok4uw	3193	2	Sequestration	Sequestration	NNP
cord-001835-0s7ok4uw	3193	3	of	of	IN
cord-001835-0s7ok4uw	3193	4	CO2	CO2	NNP
cord-001835-0s7ok4uw	3193	5	:	:	:
cord-001835-0s7ok4uw	3194	1	reprogramming	reprogramme	VBG
cord-001835-0s7ok4uw	3194	2	the	the	DT
cord-001835-0s7ok4uw	3194	3	B1	b1	NN
cord-001835-0s7ok4uw	3194	4	domain	domain	NN
cord-001835-0s7ok4uw	3194	5	of	of	IN
cord-001835-0s7ok4uw	3194	6	protein	protein	NN
cord-001835-0s7ok4uw	3194	7	g	g	NN
cord-001835-0s7ok4uw	3194	8	through	through	IN
cord-001835-0s7ok4uw	3194	9	a	a	DT
cord-001835-0s7ok4uw	3194	10	combined	combine	VBN
cord-001835-0s7ok4uw	3194	11	computational	computational	JJ
cord-001835-0s7ok4uw	3194	12	and	and	CC
cord-001835-0s7ok4uw	3194	13	experimental	experimental	JJ
cord-001835-0s7ok4uw	3194	14	approach	approach	NN
cord-001835-0s7ok4uw	3194	15	Esra	Esra	NNP
cord-001835-0s7ok4uw	3194	16	Bozkurt	Bozkurt	NNP
cord-001835-0s7ok4uw	3194	17	1	1	CD
cord-001835-0s7ok4uw	3194	18	,	,	,
cord-001835-0s7ok4uw	3194	19	Ruud	Ruud	NNP
cord-001835-0s7ok4uw	3194	20	Hovius	Hovius	NNP
cord-001835-0s7ok4uw	3194	21	1	1	CD
cord-001835-0s7ok4uw	3194	22	,	,	,
cord-001835-0s7ok4uw	3194	23	Thereza	Thereza	NNP
cord-001835-0s7ok4uw	3194	24	A.	a.	NN
cord-001835-0s7ok4uw	3194	25	Soares	Soares	NNP
cord-001835-0s7ok4uw	3194	26	2	2	CD
cord-001835-0s7ok4uw	3194	27	,	,	,
cord-001835-0s7ok4uw	3194	28	Ursula	Ursula	NNP
cord-001835-0s7ok4uw	3194	29	Rothlisberger	Rothlisberger	NNP
cord-001835-0s7ok4uw	3194	30	1	1	CD
cord-001835-0s7ok4uw	3194	31	1	1	CD
cord-001835-0s7ok4uw	3194	32	Ecole	Ecole	NNP
cord-001835-0s7ok4uw	3194	33	Polytechnique	Polytechnique	NNP
cord-001835-0s7ok4uw	3194	34	F	F	NNP
cord-001835-0s7ok4uw	3194	35	ed	ed	NN
cord-001835-0s7ok4uw	3194	36	erale	erale	NN
cord-001835-0s7ok4uw	3194	37	de	de	FW
cord-001835-0s7ok4uw	3194	38	Lausanne	Lausanne	NNP
cord-001835-0s7ok4uw	3194	39	,	,	,
cord-001835-0s7ok4uw	3194	40	2	2	CD
cord-001835-0s7ok4uw	3194	41	Federal	Federal	NNP
cord-001835-0s7ok4uw	3194	42	University	University	NNP
cord-001835-0s7ok4uw	3194	43	of	of	IN
cord-001835-0s7ok4uw	3194	44	Pernambuco	Pernambuco	NNP
cord-001835-0s7ok4uw	3194	45	Protein	Protein	NNP
cord-001835-0s7ok4uw	3194	46	engineering	engineering	NN
cord-001835-0s7ok4uw	3194	47	is	be	VBZ
cord-001835-0s7ok4uw	3194	48	a	a	DT
cord-001835-0s7ok4uw	3194	49	powerful	powerful	JJ
cord-001835-0s7ok4uw	3194	50	tool	tool	NN
cord-001835-0s7ok4uw	3194	51	to	to	TO
cord-001835-0s7ok4uw	3194	52	generate	generate	VB
cord-001835-0s7ok4uw	3194	53	highly	highly	RB
cord-001835-0s7ok4uw	3194	54	specific	specific	JJ
cord-001835-0s7ok4uw	3194	55	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3194	56	for	for	IN
cord-001835-0s7ok4uw	3194	57	biomimetic	biomimetic	JJ
cord-001835-0s7ok4uw	3194	58	production	production	NN
cord-001835-0s7ok4uw	3194	59	of	of	IN
cord-001835-0s7ok4uw	3194	60	chemicals	chemical	NNS
cord-001835-0s7ok4uw	3194	61	.	.	.
cord-001835-0s7ok4uw	3195	1	Among	among	IN
cord-001835-0s7ok4uw	3195	2	many	many	JJ
cord-001835-0s7ok4uw	3195	3	applications	application	NNS
cord-001835-0s7ok4uw	3195	4	,	,	,
cord-001835-0s7ok4uw	3195	5	the	the	DT
cord-001835-0s7ok4uw	3195	6	development	development	NN
cord-001835-0s7ok4uw	3195	7	of	of	IN
cord-001835-0s7ok4uw	3195	8	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3195	9	to	to	TO
cord-001835-0s7ok4uw	3195	10	accelerate	accelerate	VB
cord-001835-0s7ok4uw	3195	11	carbon	carbon	NN
cord-001835-0s7ok4uw	3195	12	dioxide	dioxide	NN
cord-001835-0s7ok4uw	3195	13	fixation	fixation	NN
cord-001835-0s7ok4uw	3195	14	is	be	VBZ
cord-001835-0s7ok4uw	3195	15	a	a	DT
cord-001835-0s7ok4uw	3195	16	possible	possible	JJ
cord-001835-0s7ok4uw	3195	17	route	route	NN
cord-001835-0s7ok4uw	3195	18	to	to	TO
cord-001835-0s7ok4uw	3195	19	limit	limit	VB
cord-001835-0s7ok4uw	3195	20	CO2	CO2	NNP
cord-001835-0s7ok4uw	3195	21	emission	emission	NN
cord-001835-0s7ok4uw	3195	22	.	.	.
cord-001835-0s7ok4uw	3196	1	In	in	IN
cord-001835-0s7ok4uw	3196	2	this	this	DT
cord-001835-0s7ok4uw	3196	3	project	project	NN
cord-001835-0s7ok4uw	3196	4	,	,	,
cord-001835-0s7ok4uw	3196	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3196	6	are	be	VBP
cord-001835-0s7ok4uw	3196	7	inspired	inspire	VBN
cord-001835-0s7ok4uw	3196	8	by	by	IN
cord-001835-0s7ok4uw	3196	9	the	the	DT
cord-001835-0s7ok4uw	3196	10	ancient	ancient	JJ
cord-001835-0s7ok4uw	3196	11	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3196	12	carbonic	carbonic	JJ
cord-001835-0s7ok4uw	3196	13	anhydrase	anhydrase	NN
cord-001835-0s7ok4uw	3196	14	which	which	WDT
cord-001835-0s7ok4uw	3196	15	efficiently	efficiently	RB
cord-001835-0s7ok4uw	3196	16	catalyzes	catalyze	VBZ
cord-001835-0s7ok4uw	3196	17	the	the	DT
cord-001835-0s7ok4uw	3196	18	reversible	reversible	JJ
cord-001835-0s7ok4uw	3196	19	hydration	hydration	NN
cord-001835-0s7ok4uw	3196	20	of	of	IN
cord-001835-0s7ok4uw	3196	21	carbon	carbon	NN
cord-001835-0s7ok4uw	3196	22	dioxide	dioxide	NN
cord-001835-0s7ok4uw	3196	23	in	in	IN
cord-001835-0s7ok4uw	3196	24	the	the	DT
cord-001835-0s7ok4uw	3196	25	presence	presence	NN
cord-001835-0s7ok4uw	3196	26	of	of	IN
cord-001835-0s7ok4uw	3196	27	a	a	DT
cord-001835-0s7ok4uw	3196	28	zinc	zinc	NN
cord-001835-0s7ok4uw	3196	29	ion	ion	NN
cord-001835-0s7ok4uw	3196	30	active	active	JJ
cord-001835-0s7ok4uw	3196	31	site.1	site.1	NN
cord-001835-0s7ok4uw	3197	1	To	to	TO
cord-001835-0s7ok4uw	3197	2	create	create	VB
cord-001835-0s7ok4uw	3197	3	an	an	DT
cord-001835-0s7ok4uw	3197	4	efficient	efficient	JJ
cord-001835-0s7ok4uw	3197	5	biocatalyst	biocatalyst	NN
cord-001835-0s7ok4uw	3197	6	,	,	,
cord-001835-0s7ok4uw	3197	7	the	the	DT
cord-001835-0s7ok4uw	3197	8	engineered	engineer	VBN
cord-001835-0s7ok4uw	3197	9	GB1	GB1	NNP
cord-001835-0s7ok4uw	3197	10	domain2	domain2	NN
cord-001835-0s7ok4uw	3197	11	containing	contain	VBG
cord-001835-0s7ok4uw	3197	12	a	a	DT
cord-001835-0s7ok4uw	3197	13	His3Cys	His3Cys	NNP
cord-001835-0s7ok4uw	3197	14	Zn	Zn	NNP
cord-001835-0s7ok4uw	3197	15	(	(	-LRB-
cord-001835-0s7ok4uw	3197	16	II	II	NNP
cord-001835-0s7ok4uw	3197	17	)	)	-RRB-
cord-001835-0s7ok4uw	3197	18	binding	binding	NN
cord-001835-0s7ok4uw	3197	19	site	site	NN
cord-001835-0s7ok4uw	3197	20	was	be	VBD
cord-001835-0s7ok4uw	3197	21	used	use	VBN
cord-001835-0s7ok4uw	3197	22	as	as	IN
cord-001835-0s7ok4uw	3197	23	a	a	DT
cord-001835-0s7ok4uw	3197	24	starting	start	VBG
cord-001835-0s7ok4uw	3197	25	point.3	point.3	NN
cord-001835-0s7ok4uw	3198	1	In	in	IN
cord-001835-0s7ok4uw	3198	2	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	3198	3	work	work	NN
cord-001835-0s7ok4uw	3198	4	,	,	,
cord-001835-0s7ok4uw	3198	5	B1	b1	NN
cord-001835-0s7ok4uw	3198	6	domains	domain	NNS
cord-001835-0s7ok4uw	3198	7	comprising	comprise	VBG
cord-001835-0s7ok4uw	3198	8	of	of	IN
cord-001835-0s7ok4uw	3198	9	His3Wat	His3Wat	NNP
cord-001835-0s7ok4uw	3198	10	Zn	Zn	NNP
cord-001835-0s7ok4uw	3198	11	(	(	-LRB-
cord-001835-0s7ok4uw	3198	12	II	II	NNP
cord-001835-0s7ok4uw	3198	13	)	)	-RRB-
cord-001835-0s7ok4uw	3198	14	binding	bind	VBG
cord-001835-0s7ok4uw	3198	15	sites	site	NNS
cord-001835-0s7ok4uw	3198	16	have	have	VBP
cord-001835-0s7ok4uw	3198	17	been	be	VBN
cord-001835-0s7ok4uw	3198	18	rationally	rationally	RB
cord-001835-0s7ok4uw	3198	19	designed	design	VBN
cord-001835-0s7ok4uw	3198	20	to	to	TO
cord-001835-0s7ok4uw	3198	21	produce	produce	VB
cord-001835-0s7ok4uw	3198	22	carbonic	carbonic	JJ
cord-001835-0s7ok4uw	3198	23	anhydrase	anhydrase	NN
cord-001835-0s7ok4uw	3198	24	mimics	mimic	NNS
cord-001835-0s7ok4uw	3198	25	.	.	.
cord-001835-0s7ok4uw	3199	1	The	the	DT
cord-001835-0s7ok4uw	3199	2	re	re	NN
cord-001835-0s7ok4uw	3199	3	-	-	NN
cord-001835-0s7ok4uw	3199	4	engineering	engineering	NN
cord-001835-0s7ok4uw	3199	5	was	be	VBD
cord-001835-0s7ok4uw	3199	6	accomplished	accomplish	VBN
cord-001835-0s7ok4uw	3199	7	through	through	IN
cord-001835-0s7ok4uw	3199	8	a	a	DT
cord-001835-0s7ok4uw	3199	9	series	series	NN
cord-001835-0s7ok4uw	3199	10	of	of	IN
cord-001835-0s7ok4uw	3199	11	mutations	mutation	NNS
cord-001835-0s7ok4uw	3199	12	to	to	TO
cord-001835-0s7ok4uw	3199	13	orient	orient	VB
cord-001835-0s7ok4uw	3199	14	the	the	DT
cord-001835-0s7ok4uw	3199	15	zinc	zinc	NN
cord-001835-0s7ok4uw	3199	16	bound	bind	VBN
cord-001835-0s7ok4uw	3199	17	reactive	reactive	JJ
cord-001835-0s7ok4uw	3199	18	species	specie	NNS
cord-001835-0s7ok4uw	3199	19	to	to	TO
cord-001835-0s7ok4uw	3199	20	form	form	VB
cord-001835-0s7ok4uw	3199	21	a	a	DT
cord-001835-0s7ok4uw	3199	22	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3199	23	bond	bond	NN
cord-001835-0s7ok4uw	3199	24	network	network	NN
cord-001835-0s7ok4uw	3199	25	in	in	IN
cord-001835-0s7ok4uw	3199	26	the	the	DT
cord-001835-0s7ok4uw	3199	27	active	active	JJ
cord-001835-0s7ok4uw	3199	28	site	site	NN
cord-001835-0s7ok4uw	3199	29	while	while	IN
cord-001835-0s7ok4uw	3199	30	retaining	retain	VBG
cord-001835-0s7ok4uw	3199	31	the	the	DT
cord-001835-0s7ok4uw	3199	32	native	native	JJ
cord-001835-0s7ok4uw	3199	33	secondary	secondary	JJ
cord-001835-0s7ok4uw	3199	34	structure	structure	NN
cord-001835-0s7ok4uw	3199	35	.	.	.
cord-001835-0s7ok4uw	3200	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3200	2	performed	perform	VBD
cord-001835-0s7ok4uw	3200	3	classical	classical	JJ
cord-001835-0s7ok4uw	3200	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	3200	5	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3200	6	(	(	-LRB-
cord-001835-0s7ok4uw	3200	7	MD	MD	NNP
cord-001835-0s7ok4uw	3200	8	)	)	-RRB-
cord-001835-0s7ok4uw	3200	9	,	,	,
cord-001835-0s7ok4uw	3200	10	quantum	quantum	NN
cord-001835-0s7ok4uw	3200	11	mechanics	mechanic	NNS
cord-001835-0s7ok4uw	3200	12	/	/	SYM
cord-001835-0s7ok4uw	3200	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	3200	14	mechanics	mechanic	NNS
cord-001835-0s7ok4uw	3200	15	(	(	-LRB-
cord-001835-0s7ok4uw	3200	16	QM/	qm/	JJ
cord-001835-0s7ok4uw	3200	17	MM	MM	NNP
cord-001835-0s7ok4uw	3200	18	)	)	-RRB-
cord-001835-0s7ok4uw	3200	19	simulations	simulation	NNS
cord-001835-0s7ok4uw	3200	20	and	and	CC
cord-001835-0s7ok4uw	3200	21	metadynamics	metadynamic	NNS
cord-001835-0s7ok4uw	3200	22	,	,	,
cord-001835-0s7ok4uw	3200	23	with	with	IN
cord-001835-0s7ok4uw	3200	24	the	the	DT
cord-001835-0s7ok4uw	3200	25	aim	aim	NN
cord-001835-0s7ok4uw	3200	26	to	to	TO
cord-001835-0s7ok4uw	3200	27	explore	explore	VB
cord-001835-0s7ok4uw	3200	28	potential	potential	JJ
cord-001835-0s7ok4uw	3200	29	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3200	30	roles	role	NNS
cord-001835-0s7ok4uw	3200	31	of	of	IN
cord-001835-0s7ok4uw	3200	32	the	the	DT
cord-001835-0s7ok4uw	3200	33	reengineered	reengineere	VBN
cord-001835-0s7ok4uw	3200	34	B1	b1	NN
cord-001835-0s7ok4uw	3200	35	domains	domain	NNS
cord-001835-0s7ok4uw	3200	36	and	and	CC
cord-001835-0s7ok4uw	3200	37	to	to	TO
cord-001835-0s7ok4uw	3200	38	elaborate	elaborate	VB
cord-001835-0s7ok4uw	3200	39	the	the	DT
cord-001835-0s7ok4uw	3200	40	reaction	reaction	NN
cord-001835-0s7ok4uw	3200	41	mechanism	mechanism	NN
cord-001835-0s7ok4uw	3200	42	.	.	.
cord-001835-0s7ok4uw	3201	1	Briefly	briefly	RB
cord-001835-0s7ok4uw	3201	2	,	,	,
cord-001835-0s7ok4uw	3201	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3201	4	introduced	introduce	VBD
cord-001835-0s7ok4uw	3201	5	novel	novel	NN
cord-001835-0s7ok4uw	3201	6	Zn	Zn	NNP
cord-001835-0s7ok4uw	3201	7	(	(	-LRB-
cord-001835-0s7ok4uw	3201	8	II	II	NNP
cord-001835-0s7ok4uw	3201	9	)	)	-RRB-
cord-001835-0s7ok4uw	3201	10	binding	bind	VBG
cord-001835-0s7ok4uw	3201	11	sites	site	NNS
cord-001835-0s7ok4uw	3201	12	into	into	IN
cord-001835-0s7ok4uw	3201	13	thermostable	thermostable	JJ
cord-001835-0s7ok4uw	3201	14	B1	b1	NN
cord-001835-0s7ok4uw	3201	15	domain	domain	NN
cord-001835-0s7ok4uw	3201	16	.	.	.
cord-001835-0s7ok4uw	3202	1	In	in	IN
cord-001835-0s7ok4uw	3202	2	parallel	parallel	NN
cord-001835-0s7ok4uw	3202	3	,	,	,
cord-001835-0s7ok4uw	3202	4	experiments	experiment	NNS
cord-001835-0s7ok4uw	3202	5	are	be	VBP
cord-001835-0s7ok4uw	3202	6	underway	underway	JJ
cord-001835-0s7ok4uw	3202	7	.	.	.
cord-001835-0s7ok4uw	3203	1	Wild	wild	JJ
cord-001835-0s7ok4uw	3203	2	-	-	HYPH
cord-001835-0s7ok4uw	3203	3	type	type	NN
cord-001835-0s7ok4uw	3203	4	protein	protein	NN
cord-001835-0s7ok4uw	3203	5	was	be	VBD
cord-001835-0s7ok4uw	3203	6	expressed	express	VBN
cord-001835-0s7ok4uw	3203	7	and	and	CC
cord-001835-0s7ok4uw	3203	8	purified	purify	VBN
cord-001835-0s7ok4uw	3203	9	.	.	.
cord-001835-0s7ok4uw	3204	1	Structural	structural	JJ
cord-001835-0s7ok4uw	3204	2	and	and	CC
cord-001835-0s7ok4uw	3204	3	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	3204	4	studies	study	NNS
cord-001835-0s7ok4uw	3204	5	are	be	VBP
cord-001835-0s7ok4uw	3204	6	ongoing	ongoing	JJ
cord-001835-0s7ok4uw	3204	7	.	.	.
cord-001835-0s7ok4uw	3205	1	The	the	DT
cord-001835-0s7ok4uw	3205	2	results	result	NNS
cord-001835-0s7ok4uw	3205	3	emphasize	emphasize	VBP
cord-001835-0s7ok4uw	3205	4	the	the	DT
cord-001835-0s7ok4uw	3205	5	power	power	NN
cord-001835-0s7ok4uw	3205	6	of	of	IN
cord-001835-0s7ok4uw	3205	7	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	3205	8	work	work	NN
cord-001835-0s7ok4uw	3205	9	to	to	TO
cord-001835-0s7ok4uw	3205	10	enable	enable	VB
cord-001835-0s7ok4uw	3205	11	the	the	DT
cord-001835-0s7ok4uw	3205	12	mimicking	mimicking	NN
cord-001835-0s7ok4uw	3205	13	of	of	IN
cord-001835-0s7ok4uw	3205	14	Nature	Nature	NNP
cord-001835-0s7ok4uw	3205	15	's	's	POS
cord-001835-0s7ok4uw	3205	16	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3205	17	for	for	IN
cord-001835-0s7ok4uw	3205	18	desired	desire	VBN
cord-001835-0s7ok4uw	3205	19	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3205	20	functions	function	NNS
cord-001835-0s7ok4uw	3205	21	.	.	.
cord-001835-0s7ok4uw	3206	1	The	the	DT
cord-001835-0s7ok4uw	3206	2	roles	role	NNS
cord-001835-0s7ok4uw	3206	3	of	of	IN
cord-001835-0s7ok4uw	3206	4	entropy	entropy	NN
cord-001835-0s7ok4uw	3206	5	and	and	CC
cord-001835-0s7ok4uw	3206	6	packing	pack	VBG
cord-001835-0s7ok4uw	3206	7	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3206	8	in	in	IN
cord-001835-0s7ok4uw	3206	9	determining	determine	VBG
cord-001835-0s7ok4uw	3206	10	protein	protein	NN
cord-001835-0s7ok4uw	3206	11	-	-	HYPH
cord-001835-0s7ok4uw	3206	12	peptide	peptide	NN
cord-001835-0s7ok4uw	3206	13	interaction	interaction	NN
cord-001835-0s7ok4uw	3206	14	affinities	affinity	NNS
cord-001835-0s7ok4uw	3206	15	Diego	Diego	NNP
cord-001835-0s7ok4uw	3206	16	Caballero	Caballero	NNP
cord-001835-0s7ok4uw	3206	17	1,2	1,2	CD
cord-001835-0s7ok4uw	3206	18	,	,	,
cord-001835-0s7ok4uw	3206	19	Corey	Corey	NNP
cord-001835-0s7ok4uw	3206	20	O'Hern	O'Hern	NNP
cord-001835-0s7ok4uw	3206	21	1,2,3,4	1,2,3,4	NNP
cord-001835-0s7ok4uw	3206	22	,	,	,
cord-001835-0s7ok4uw	3206	23	Lynne	Lynne	NNP
cord-001835-0s7ok4uw	3206	24	Regan	Regan	NNP
cord-001835-0s7ok4uw	3206	25	2,5,6	2,5,6	CD
cord-001835-0s7ok4uw	3206	26	1	1	CD
cord-001835-0s7ok4uw	3206	27	Physics	Physics	NNP
cord-001835-0s7ok4uw	3206	28	,	,	,
cord-001835-0s7ok4uw	3206	29	Yale	Yale	NNP
cord-001835-0s7ok4uw	3206	30	University	University	NNP
cord-001835-0s7ok4uw	3206	31	,	,	,
cord-001835-0s7ok4uw	3206	32	2	2	CD
cord-001835-0s7ok4uw	3206	33	Integrated	Integrated	NNP
cord-001835-0s7ok4uw	3206	34	Graduate	Graduate	NNP
cord-001835-0s7ok4uw	3206	35	Program	Program	NNP
cord-001835-0s7ok4uw	3206	36	in	in	IN
cord-001835-0s7ok4uw	3206	37	Physical	Physical	NNP
cord-001835-0s7ok4uw	3206	38	and	and	CC
cord-001835-0s7ok4uw	3206	39	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	3206	40	Biology	Biology	NNP
cord-001835-0s7ok4uw	3206	41	,	,	,
cord-001835-0s7ok4uw	3206	42	Yale	Yale	NNP
cord-001835-0s7ok4uw	3206	43	University	University	NNP
cord-001835-0s7ok4uw	3206	44	,	,	,
cord-001835-0s7ok4uw	3206	45	3	3	CD
cord-001835-0s7ok4uw	3206	46	Mechanical	Mechanical	NNP
cord-001835-0s7ok4uw	3206	47	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	3206	48	and	and	CC
cord-001835-0s7ok4uw	3206	49	Materials	Materials	NNPS
cord-001835-0s7ok4uw	3206	50	Science	Science	NNP
cord-001835-0s7ok4uw	3206	51	,	,	,
cord-001835-0s7ok4uw	3206	52	Yale	Yale	NNP
cord-001835-0s7ok4uw	3206	53	University	University	NNP
cord-001835-0s7ok4uw	3206	54	,	,	,
cord-001835-0s7ok4uw	3206	55	4	4	CD
cord-001835-0s7ok4uw	3206	56	Applied	Applied	NNP
cord-001835-0s7ok4uw	3206	57	Physics	Physics	NNP
cord-001835-0s7ok4uw	3206	58	,	,	,
cord-001835-0s7ok4uw	3206	59	Yale	Yale	NNP
cord-001835-0s7ok4uw	3206	60	University	University	NNP
cord-001835-0s7ok4uw	3206	61	,	,	,
cord-001835-0s7ok4uw	3206	62	5	5	CD
cord-001835-0s7ok4uw	3206	63	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	3206	64	Biophysics	Biophysics	NNP
cord-001835-0s7ok4uw	3206	65	and	and	CC
cord-001835-0s7ok4uw	3206	66	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	3206	67	,	,	,
cord-001835-0s7ok4uw	3206	68	Yale	Yale	NNP
cord-001835-0s7ok4uw	3206	69	University	University	NNP
cord-001835-0s7ok4uw	3206	70	,	,	,
cord-001835-0s7ok4uw	3206	71	6	6	CD
cord-001835-0s7ok4uw	3206	72	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	3206	73	,	,	,
cord-001835-0s7ok4uw	3206	74	Yale	Yale	NNP
cord-001835-0s7ok4uw	3206	75	University	University	NNP
cord-001835-0s7ok4uw	3207	1	Despite	despite	IN
cord-001835-0s7ok4uw	3207	2	many	many	JJ
cord-001835-0s7ok4uw	3207	3	recent	recent	JJ
cord-001835-0s7ok4uw	3207	4	improvements	improvement	NNS
cord-001835-0s7ok4uw	3207	5	in	in	IN
cord-001835-0s7ok4uw	3207	6	computational	computational	JJ
cord-001835-0s7ok4uw	3207	7	methods	method	NNS
cord-001835-0s7ok4uw	3207	8	for	for	IN
cord-001835-0s7ok4uw	3207	9	protein	protein	NN
cord-001835-0s7ok4uw	3207	10	design	design	NN
cord-001835-0s7ok4uw	3207	11	,	,	,
cord-001835-0s7ok4uw	3207	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	3207	13	still	still	RB
cord-001835-0s7ok4uw	3207	14	lack	lack	VBP
cord-001835-0s7ok4uw	3207	15	a	a	DT
cord-001835-0s7ok4uw	3207	16	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	3207	17	and	and	CC
cord-001835-0s7ok4uw	3207	18	predictive	predictive	JJ
cord-001835-0s7ok4uw	3207	19	understanding	understanding	NN
cord-001835-0s7ok4uw	3207	20	of	of	IN
cord-001835-0s7ok4uw	3207	21	the	the	DT
cord-001835-0s7ok4uw	3207	22	driving	drive	VBG
cord-001835-0s7ok4uw	3207	23	forces	force	NNS
cord-001835-0s7ok4uw	3207	24	that	that	WDT
cord-001835-0s7ok4uw	3207	25	control	control	VBP
cord-001835-0s7ok4uw	3207	26	protein	protein	NN
cord-001835-0s7ok4uw	3207	27	stability	stability	NN
cord-001835-0s7ok4uw	3207	28	,	,	,
cord-001835-0s7ok4uw	3207	29	for	for	IN
cord-001835-0s7ok4uw	3207	30	example	example	NN
cord-001835-0s7ok4uw	3207	31	,	,	,
cord-001835-0s7ok4uw	3207	32	we	-PRON-	PRP
cord-001835-0s7ok4uw	3207	33	do	do	VBP
cord-001835-0s7ok4uw	3207	34	not	not	RB
cord-001835-0s7ok4uw	3207	35	know	know	VB
cord-001835-0s7ok4uw	3207	36	the	the	DT
cord-001835-0s7ok4uw	3207	37	relative	relative	JJ
cord-001835-0s7ok4uw	3207	38	magnitudes	magnitude	NNS
cord-001835-0s7ok4uw	3207	39	of	of	IN
cord-001835-0s7ok4uw	3207	40	the	the	DT
cord-001835-0s7ok4uw	3207	41	side	side	NN
cord-001835-0s7ok4uw	3207	42	-	-	HYPH
cord-001835-0s7ok4uw	3207	43	chain	chain	NN
cord-001835-0s7ok4uw	3207	44	entropy	entropy	NN
cord-001835-0s7ok4uw	3207	45	,	,	,
cord-001835-0s7ok4uw	3207	46	van	van	NNP
cord-001835-0s7ok4uw	3207	47	der	der	NNP
cord-001835-0s7ok4uw	3207	48	Waals	Waals	NNP
cord-001835-0s7ok4uw	3207	49	contact	contact	NN
cord-001835-0s7ok4uw	3207	50	interactions	interaction	NNS
cord-001835-0s7ok4uw	3207	51	,	,	,
cord-001835-0s7ok4uw	3207	52	and	and	CC
cord-001835-0s7ok4uw	3207	53	other	other	JJ
cord-001835-0s7ok4uw	3207	54	enthalpic	enthalpic	JJ
cord-001835-0s7ok4uw	3207	55	contributions	contribution	NNS
cord-001835-0s7ok4uw	3207	56	to	to	IN
cord-001835-0s7ok4uw	3207	57	the	the	DT
cord-001835-0s7ok4uw	3207	58	free	free	JJ
cord-001835-0s7ok4uw	3207	59	energy	energy	NN
cord-001835-0s7ok4uw	3207	60	of	of	IN
cord-001835-0s7ok4uw	3207	61	folded	fold	VBN
cord-001835-0s7ok4uw	3207	62	proteins	protein	NNS
cord-001835-0s7ok4uw	3207	63	.	.	.
cord-001835-0s7ok4uw	3208	1	In	in	IN
cord-001835-0s7ok4uw	3208	2	addition	addition	NN
cord-001835-0s7ok4uw	3208	3	,	,	,
cord-001835-0s7ok4uw	3208	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3208	5	can	can	MD
cord-001835-0s7ok4uw	3208	6	not	not	RB
cord-001835-0s7ok4uw	3208	7	reliably	reliably	RB
cord-001835-0s7ok4uw	3208	8	predict	predict	VB
cord-001835-0s7ok4uw	3208	9	the	the	DT
cord-001835-0s7ok4uw	3208	10	effects	effect	NNS
cord-001835-0s7ok4uw	3208	11	of	of	IN
cord-001835-0s7ok4uw	3208	12	point	point	NN
cord-001835-0s7ok4uw	3208	13	mutations	mutation	NNS
cord-001835-0s7ok4uw	3208	14	on	on	IN
cord-001835-0s7ok4uw	3208	15	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3208	16	specificity	specificity	NN
cord-001835-0s7ok4uw	3208	17	or	or	CC
cord-001835-0s7ok4uw	3208	18	sequence	sequence	NN
cord-001835-0s7ok4uw	3208	19	tolerance	tolerance	NN
cord-001835-0s7ok4uw	3208	20	in	in	IN
cord-001835-0s7ok4uw	3208	21	ligand	ligand	NN
cord-001835-0s7ok4uw	3208	22	binding	binding	NN
cord-001835-0s7ok4uw	3208	23	sites	site	NNS
cord-001835-0s7ok4uw	3208	24	.	.	.
cord-001835-0s7ok4uw	3209	1	The	the	DT
cord-001835-0s7ok4uw	3209	2	tetratricopeptide	tetratricopeptide	JJ
cord-001835-0s7ok4uw	3209	3	repeat	repeat	NN
cord-001835-0s7ok4uw	3209	4	(	(	-LRB-
cord-001835-0s7ok4uw	3209	5	TPR	TPR	NNP
cord-001835-0s7ok4uw	3209	6	)	)	-RRB-
cord-001835-0s7ok4uw	3209	7	motif	motif	NN
cord-001835-0s7ok4uw	3209	8	is	be	VBZ
cord-001835-0s7ok4uw	3209	9	a	a	DT
cord-001835-0s7ok4uw	3209	10	common	common	JJ
cord-001835-0s7ok4uw	3209	11	and	and	CC
cord-001835-0s7ok4uw	3209	12	versatile	versatile	JJ
cord-001835-0s7ok4uw	3209	13	protein	protein	NN
cord-001835-0s7ok4uw	3209	14	system	system	NN
cord-001835-0s7ok4uw	3209	15	that	that	WDT
cord-001835-0s7ok4uw	3209	16	has	have	VBZ
cord-001835-0s7ok4uw	3209	17	been	be	VBN
cord-001835-0s7ok4uw	3209	18	used	use	VBN
cord-001835-0s7ok4uw	3209	19	as	as	IN
cord-001835-0s7ok4uw	3209	20	a	a	DT
cord-001835-0s7ok4uw	3209	21	model	model	NN
cord-001835-0s7ok4uw	3209	22	to	to	TO
cord-001835-0s7ok4uw	3209	23	study	study	VB
cord-001835-0s7ok4uw	3209	24	protein	protein	NN
cord-001835-0s7ok4uw	3209	25	-	-	HYPH
cord-001835-0s7ok4uw	3209	26	protein	protein	NN
cord-001835-0s7ok4uw	3209	27	interactions	interaction	NNS
cord-001835-0s7ok4uw	3209	28	.	.	.
cord-001835-0s7ok4uw	3210	1	For	for	IN
cord-001835-0s7ok4uw	3210	2	example	example	NN
cord-001835-0s7ok4uw	3210	3	,	,	,
cord-001835-0s7ok4uw	3210	4	recent	recent	JJ
cord-001835-0s7ok4uw	3210	5	studies	study	NNS
cord-001835-0s7ok4uw	3210	6	have	have	VBP
cord-001835-0s7ok4uw	3210	7	experimentally	experimentally	RB
cord-001835-0s7ok4uw	3210	8	measured	measure	VBN
cord-001835-0s7ok4uw	3210	9	the	the	DT
cord-001835-0s7ok4uw	3210	10	binding	bind	VBG
cord-001835-0s7ok4uw	3210	11	affinity	affinity	NN
cord-001835-0s7ok4uw	3210	12	and	and	CC
cord-001835-0s7ok4uw	3210	13	specificity	specificity	NN
cord-001835-0s7ok4uw	3210	14	for	for	IN
cord-001835-0s7ok4uw	3210	15	different	different	JJ
cord-001835-0s7ok4uw	3210	16	TPR	TPR	NNP
cord-001835-0s7ok4uw	3210	17	binding	bind	VBG
cord-001835-0s7ok4uw	3210	18	pockets	pocket	NNS
cord-001835-0s7ok4uw	3210	19	and	and	CC
cord-001835-0s7ok4uw	3210	20	peptide	peptide	NN
cord-001835-0s7ok4uw	3210	21	ligands	ligand	NNS
cord-001835-0s7ok4uw	3210	22	and	and	CC
cord-001835-0s7ok4uw	3210	23	generated	generate	VBD
cord-001835-0s7ok4uw	3210	24	a	a	DT
cord-001835-0s7ok4uw	3210	25	ranking	ranking	NN
cord-001835-0s7ok4uw	3210	26	of	of	IN
cord-001835-0s7ok4uw	3210	27	the	the	DT
cord-001835-0s7ok4uw	3210	28	protein	protein	NN
cord-001835-0s7ok4uw	3210	29	-	-	HYPH
cord-001835-0s7ok4uw	3210	30	peptide	peptide	NN
cord-001835-0s7ok4uw	3210	31	pairs	pair	NNS
cord-001835-0s7ok4uw	3210	32	with	with	IN
cord-001835-0s7ok4uw	3210	33	the	the	DT
cord-001835-0s7ok4uw	3210	34	highest	high	JJS
cord-001835-0s7ok4uw	3210	35	affinity	affinity	NN
cord-001835-0s7ok4uw	3210	36	.	.	.
cord-001835-0s7ok4uw	3211	1	To	to	TO
cord-001835-0s7ok4uw	3211	2	gain	gain	VB
cord-001835-0s7ok4uw	3211	3	a	a	DT
cord-001835-0s7ok4uw	3211	4	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	3211	5	understanding	understanding	NN
cord-001835-0s7ok4uw	3211	6	of	of	IN
cord-001835-0s7ok4uw	3211	7	the	the	DT
cord-001835-0s7ok4uw	3211	8	interplay	interplay	NN
cord-001835-0s7ok4uw	3211	9	between	between	IN
cord-001835-0s7ok4uw	3211	10	atomic	atomic	JJ
cord-001835-0s7ok4uw	3211	11	close	close	JJ
cord-001835-0s7ok4uw	3211	12	packing	packing	NN
cord-001835-0s7ok4uw	3211	13	and	and	CC
cord-001835-0s7ok4uw	3211	14	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	3211	15	of	of	IN
cord-001835-0s7ok4uw	3211	16	side	side	NN
cord-001835-0s7ok4uw	3211	17	-	-	HYPH
cord-001835-0s7ok4uw	3211	18	chain	chain	NN
cord-001835-0s7ok4uw	3211	19	conformations	conformation	NNS
cord-001835-0s7ok4uw	3211	20	in	in	IN
cord-001835-0s7ok4uw	3211	21	protein	protein	NN
cord-001835-0s7ok4uw	3211	22	-	-	HYPH
cord-001835-0s7ok4uw	3211	23	peptide	peptide	NN
cord-001835-0s7ok4uw	3211	24	binding	binding	NN
cord-001835-0s7ok4uw	3211	25	pairs	pair	NNS
cord-001835-0s7ok4uw	3211	26	,	,	,
cord-001835-0s7ok4uw	3211	27	we	-PRON-	PRP
cord-001835-0s7ok4uw	3211	28	performed	perform	VBD
cord-001835-0s7ok4uw	3211	29	all	all	DT
cord-001835-0s7ok4uw	3211	30	-	-	HYPH
cord-001835-0s7ok4uw	3211	31	atom	atom	NN
cord-001835-0s7ok4uw	3211	32	Langevin	Langevin	NNP
cord-001835-0s7ok4uw	3211	33	Dynamics	Dynamics	NNPS
cord-001835-0s7ok4uw	3211	34	simulations	simulation	NNS
cord-001835-0s7ok4uw	3211	35	of	of	IN
cord-001835-0s7ok4uw	3211	36	key	key	JJ
cord-001835-0s7ok4uw	3211	37	residues	residue	NNS
cord-001835-0s7ok4uw	3211	38	near	near	IN
cord-001835-0s7ok4uw	3211	39	the	the	DT
cord-001835-0s7ok4uw	3211	40	binding	bind	VBG
cord-001835-0s7ok4uw	3211	41	interface	interface	NN
cord-001835-0s7ok4uw	3211	42	of	of	IN
cord-001835-0s7ok4uw	3211	43	TPR	TPR	NNP
cord-001835-0s7ok4uw	3211	44	proteins	protein	NNS
cord-001835-0s7ok4uw	3211	45	and	and	CC
cord-001835-0s7ok4uw	3211	46	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3211	47	cognate	cognate	JJ
cord-001835-0s7ok4uw	3211	48	peptides	peptide	NNS
cord-001835-0s7ok4uw	3211	49	.	.	.
cord-001835-0s7ok4uw	3212	1	The	the	DT
cord-001835-0s7ok4uw	3212	2	Langevin	Langevin	NNP
cord-001835-0s7ok4uw	3212	3	Dynamics	Dynamics	NNPS
cord-001835-0s7ok4uw	3212	4	simulations	simulation	NNS
cord-001835-0s7ok4uw	3212	5	enabled	enable	VBD
cord-001835-0s7ok4uw	3212	6	us	-PRON-	PRP
cord-001835-0s7ok4uw	3212	7	to	to	TO
cord-001835-0s7ok4uw	3212	8	calculate	calculate	VB
cord-001835-0s7ok4uw	3212	9	the	the	DT
cord-001835-0s7ok4uw	3212	10	entropy	entropy	NN
cord-001835-0s7ok4uw	3212	11	and	and	CC
cord-001835-0s7ok4uw	3212	12	potential	potential	JJ
cord-001835-0s7ok4uw	3212	13	energy	energy	NN
cord-001835-0s7ok4uw	3212	14	of	of	IN
cord-001835-0s7ok4uw	3212	15	side	side	NN
cord-001835-0s7ok4uw	3212	16	chain	chain	NN
cord-001835-0s7ok4uw	3212	17	conformations	conformation	NNS
cord-001835-0s7ok4uw	3212	18	in	in	IN
cord-001835-0s7ok4uw	3212	19	the	the	DT
cord-001835-0s7ok4uw	3212	20	presence	presence	NN
cord-001835-0s7ok4uw	3212	21	of	of	IN
cord-001835-0s7ok4uw	3212	22	backbone	backbone	NN
cord-001835-0s7ok4uw	3212	23	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	3212	24	for	for	IN
cord-001835-0s7ok4uw	3212	25	each	each	DT
cord-001835-0s7ok4uw	3212	26	protein	protein	NN
cord-001835-0s7ok4uw	3212	27	-	-	HYPH
cord-001835-0s7ok4uw	3212	28	peptide	peptide	JJ
cord-001835-0s7ok4uw	3212	29	pair	pair	NN
cord-001835-0s7ok4uw	3212	30	.	.	.
cord-001835-0s7ok4uw	3213	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3213	2	compile	compile	VBP
cord-001835-0s7ok4uw	3213	3	rankings	ranking	NNS
cord-001835-0s7ok4uw	3213	4	of	of	IN
cord-001835-0s7ok4uw	3213	5	the	the	DT
cord-001835-0s7ok4uw	3213	6	stability	stability	NN
cord-001835-0s7ok4uw	3213	7	and	and	CC
cord-001835-0s7ok4uw	3213	8	affinity	affinity	NN
cord-001835-0s7ok4uw	3213	9	of	of	IN
cord-001835-0s7ok4uw	3213	10	mutant	mutant	JJ
cord-001835-0s7ok4uw	3213	11	TPR	TPR	NNP
cord-001835-0s7ok4uw	3213	12	-	-	HYPH
cord-001835-0s7ok4uw	3213	13	peptide	peptide	NN
cord-001835-0s7ok4uw	3213	14	structures	structure	NNS
cord-001835-0s7ok4uw	3213	15	to	to	IN
cord-001835-0s7ok4uw	3213	16	those	those	DT
cord-001835-0s7ok4uw	3213	17	obtained	obtain	VBN
cord-001835-0s7ok4uw	3213	18	from	from	IN
cord-001835-0s7ok4uw	3213	19	experimental	experimental	JJ
cord-001835-0s7ok4uw	3213	20	studies	study	NNS
cord-001835-0s7ok4uw	3213	21	.	.	.
cord-001835-0s7ok4uw	3214	1	This	this	DT
cord-001835-0s7ok4uw	3214	2	research	research	NN
cord-001835-0s7ok4uw	3214	3	has	have	VBZ
cord-001835-0s7ok4uw	3214	4	enhanced	enhance	VBN
cord-001835-0s7ok4uw	3214	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3214	6	ability	ability	NN
cord-001835-0s7ok4uw	3214	7	to	to	TO
cord-001835-0s7ok4uw	3214	8	rationally	rationally	RB
cord-001835-0s7ok4uw	3214	9	manipulate	manipulate	VB
cord-001835-0s7ok4uw	3214	10	protein	protein	NN
cord-001835-0s7ok4uw	3214	11	-	-	HYPH
cord-001835-0s7ok4uw	3214	12	peptide	peptide	NN
cord-001835-0s7ok4uw	3214	13	interfaces	interface	NNS
cord-001835-0s7ok4uw	3214	14	.	.	.
cord-001835-0s7ok4uw	3215	1	Advances	advance	NNS
cord-001835-0s7ok4uw	3215	2	from	from	IN
cord-001835-0s7ok4uw	3215	3	this	this	DT
cord-001835-0s7ok4uw	3215	4	research	research	NN
cord-001835-0s7ok4uw	3215	5	will	will	MD
cord-001835-0s7ok4uw	3215	6	enable	enable	VB
cord-001835-0s7ok4uw	3215	7	the	the	DT
cord-001835-0s7ok4uw	3215	8	design	design	NN
cord-001835-0s7ok4uw	3215	9	of	of	IN
cord-001835-0s7ok4uw	3215	10	TPR	TPR	NNP
cord-001835-0s7ok4uw	3215	11	modules	module	NNS
cord-001835-0s7ok4uw	3215	12	that	that	WDT
cord-001835-0s7ok4uw	3215	13	specifically	specifically	RB
cord-001835-0s7ok4uw	3215	14	recognize	recognize	VBP
cord-001835-0s7ok4uw	3215	15	biologically	biologically	RB
cord-001835-0s7ok4uw	3215	16	important	important	JJ
cord-001835-0s7ok4uw	3215	17	proteins	protein	NNS
cord-001835-0s7ok4uw	3215	18	.	.	.
cord-001835-0s7ok4uw	3216	1	Monitoring	monitor	VBG
cord-001835-0s7ok4uw	3216	2	protein	protein	NN
cord-001835-0s7ok4uw	3216	3	-	-	HYPH
cord-001835-0s7ok4uw	3216	4	protein	protein	NN
cord-001835-0s7ok4uw	3216	5	interactions	interaction	NNS
cord-001835-0s7ok4uw	3216	6	using	use	VBG
cord-001835-0s7ok4uw	3217	1	tripartite	tripartite	JJ
cord-001835-0s7ok4uw	3217	2	split	split	VBN
cord-001835-0s7ok4uw	3217	3	-	-	HYPH
cord-001835-0s7ok4uw	3217	4	GFP	gfp	NN
cord-001835-0s7ok4uw	3217	5	complementation	complementation	NN
cord-001835-0s7ok4uw	3217	6	assays	assays	RB
cord-001835-0s7ok4uw	3218	1	Protein	protein	NN
cord-001835-0s7ok4uw	3218	2	-	-	HYPH
cord-001835-0s7ok4uw	3218	3	fragment	fragment	NN
cord-001835-0s7ok4uw	3218	4	complementation	complementation	NN
cord-001835-0s7ok4uw	3218	5	assay	assay	NN
cord-001835-0s7ok4uw	3218	6	(	(	-LRB-
cord-001835-0s7ok4uw	3218	7	or	or	CC
cord-001835-0s7ok4uw	3218	8	PCA	PCA	NNP
cord-001835-0s7ok4uw	3218	9	)	)	-RRB-
cord-001835-0s7ok4uw	3218	10	is	be	VBZ
cord-001835-0s7ok4uw	3218	11	a	a	DT
cord-001835-0s7ok4uw	3218	12	powerful	powerful	JJ
cord-001835-0s7ok4uw	3218	13	strategy	strategy	NN
cord-001835-0s7ok4uw	3218	14	for	for	IN
cord-001835-0s7ok4uw	3218	15	visualizing	visualize	VBG
cord-001835-0s7ok4uw	3218	16	protein	protein	NN
cord-001835-0s7ok4uw	3218	17	-	-	HYPH
cord-001835-0s7ok4uw	3218	18	protein	protein	NN
cord-001835-0s7ok4uw	3218	19	interactions	interaction	NNS
cord-001835-0s7ok4uw	3218	20	in	in	IN
cord-001835-0s7ok4uw	3218	21	living	living	NN
cord-001835-0s7ok4uw	3218	22	cells	cell	NNS
cord-001835-0s7ok4uw	3218	23	.	.	.
cord-001835-0s7ok4uw	3219	1	Previously	previously	RB
cord-001835-0s7ok4uw	3219	2	described	describe	VBN
cord-001835-0s7ok4uw	3219	3	split	split	NN
cord-001835-0s7ok4uw	3219	4	-	-	HYPH
cord-001835-0s7ok4uw	3219	5	GFP	gfp	NN
cord-001835-0s7ok4uw	3219	6	based	base	VBN
cord-001835-0s7ok4uw	3219	7	sensors	sensor	NNS
cord-001835-0s7ok4uw	3219	8	suffer	suffer	VBP
cord-001835-0s7ok4uw	3219	9	from	from	IN
cord-001835-0s7ok4uw	3219	10	the	the	DT
cord-001835-0s7ok4uw	3219	11	poor	poor	JJ
cord-001835-0s7ok4uw	3219	12	solubility	solubility	NN
cord-001835-0s7ok4uw	3219	13	of	of	IN
cord-001835-0s7ok4uw	3219	14	individual	individual	JJ
cord-001835-0s7ok4uw	3219	15	PCA	PCA	NNP
cord-001835-0s7ok4uw	3219	16	fragments	fragment	NNS
cord-001835-0s7ok4uw	3219	17	in	in	IN
cord-001835-0s7ok4uw	3219	18	addition	addition	NN
cord-001835-0s7ok4uw	3219	19	to	to	IN
cord-001835-0s7ok4uw	3219	20	background	background	NN
cord-001835-0s7ok4uw	3219	21	signal	signal	NN
cord-001835-0s7ok4uw	3219	22	originating	originate	VBG
cord-001835-0s7ok4uw	3219	23	from	from	IN
cord-001835-0s7ok4uw	3219	24	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3219	25	spontaneous	spontaneous	JJ
cord-001835-0s7ok4uw	3219	26	selfassembly	selfassembly	NN
cord-001835-0s7ok4uw	3219	27	(	(	-LRB-
cord-001835-0s7ok4uw	3219	28	1	1	CD
cord-001835-0s7ok4uw	3219	29	)	)	-RRB-
cord-001835-0s7ok4uw	3219	30	.	.	.
cord-001835-0s7ok4uw	3220	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3220	2	developed	develop	VBD
cord-001835-0s7ok4uw	3220	3	a	a	DT
cord-001835-0s7ok4uw	3220	4	new	new	JJ
cord-001835-0s7ok4uw	3220	5	encoded	encoded	JJ
cord-001835-0s7ok4uw	3220	6	genetic	genetic	JJ
cord-001835-0s7ok4uw	3220	7	reporter	reporter	NN
cord-001835-0s7ok4uw	3220	8	called	call	VBN
cord-001835-0s7ok4uw	3220	9	"	"	``
cord-001835-0s7ok4uw	3220	10	tripartite	tripartite	JJ
cord-001835-0s7ok4uw	3220	11	split	split	NN
cord-001835-0s7ok4uw	3220	12	-	-	HYPH
cord-001835-0s7ok4uw	3220	13	GFP	gfp	NN
cord-001835-0s7ok4uw	3220	14	"	"	''
cord-001835-0s7ok4uw	3220	15	for	for	IN
cord-001835-0s7ok4uw	3220	16	visualizing	visualize	VBG
cord-001835-0s7ok4uw	3220	17	protein	protein	NN
cord-001835-0s7ok4uw	3220	18	-	-	HYPH
cord-001835-0s7ok4uw	3220	19	protein	protein	NN
cord-001835-0s7ok4uw	3220	20	interactions	interaction	NNS
cord-001835-0s7ok4uw	3220	21	in	in	IN
cord-001835-0s7ok4uw	3220	22	vitro	vitro	FW
cord-001835-0s7ok4uw	3220	23	and	and	CC
cord-001835-0s7ok4uw	3220	24	in	in	IN
cord-001835-0s7ok4uw	3220	25	living	living	NN
cord-001835-0s7ok4uw	3220	26	cells	cell	NNS
cord-001835-0s7ok4uw	3220	27	.	.	.
cord-001835-0s7ok4uw	3221	1	The	the	DT
cord-001835-0s7ok4uw	3221	2	assay	assay	NN
cord-001835-0s7ok4uw	3221	3	is	be	VBZ
cord-001835-0s7ok4uw	3221	4	based	base	VBN
cord-001835-0s7ok4uw	3221	5	on	on	IN
cord-001835-0s7ok4uw	3221	6	tripartite	tripartite	NNP
cord-001835-0s7ok4uw	3221	7	association	association	NN
cord-001835-0s7ok4uw	3221	8	between	between	IN
cord-001835-0s7ok4uw	3221	9	two	two	CD
cord-001835-0s7ok4uw	3221	10	twenty	twenty	CD
cord-001835-0s7ok4uw	3221	11	amino	amino	NNS
cord-001835-0s7ok4uw	3221	12	-	-	HYPH
cord-001835-0s7ok4uw	3221	13	acids	acid	NNS
cord-001835-0s7ok4uw	3221	14	long	long	JJ
cord-001835-0s7ok4uw	3221	15	split	split	VBN
cord-001835-0s7ok4uw	3221	16	-	-	HYPH
cord-001835-0s7ok4uw	3221	17	GFP	gfp	NN
cord-001835-0s7ok4uw	3221	18	tags	tag	NNS
cord-001835-0s7ok4uw	3221	19	,	,	,
cord-001835-0s7ok4uw	3221	20	GFP10	GFP10	NNP
cord-001835-0s7ok4uw	3221	21	and	and	CC
cord-001835-0s7ok4uw	3221	22	GFP11	GFP11	NNP
cord-001835-0s7ok4uw	3221	23	,	,	,
cord-001835-0s7ok4uw	3221	24	fused	fuse	VBN
cord-001835-0s7ok4uw	3221	25	to	to	IN
cord-001835-0s7ok4uw	3221	26	interacting	interact	VBG
cord-001835-0s7ok4uw	3221	27	protein	protein	NN
cord-001835-0s7ok4uw	3221	28	partners	partner	NNS
cord-001835-0s7ok4uw	3221	29	,	,	,
cord-001835-0s7ok4uw	3221	30	and	and	CC
cord-001835-0s7ok4uw	3221	31	the	the	DT
cord-001835-0s7ok4uw	3221	32	complementary	complementary	JJ
cord-001835-0s7ok4uw	3221	33	GFP1	GFP1	NNP
cord-001835-0s7ok4uw	3221	34	-	-	HYPH
cord-001835-0s7ok4uw	3221	35	9	9	CD
cord-001835-0s7ok4uw	3221	36	detector	detector	NN
cord-001835-0s7ok4uw	3221	37	.	.	.
cord-001835-0s7ok4uw	3222	1	When	when	WRB
cord-001835-0s7ok4uw	3222	2	proteins	protein	NNS
cord-001835-0s7ok4uw	3222	3	interact	interact	VBP
cord-001835-0s7ok4uw	3222	4	,	,	,
cord-001835-0s7ok4uw	3222	5	GFP10	GFP10	NNP
cord-001835-0s7ok4uw	3222	6	and	and	CC
cord-001835-0s7ok4uw	3222	7	GFP11	GFP11	NNP
cord-001835-0s7ok4uw	3222	8	selfassociate	selfassociate	NN
cord-001835-0s7ok4uw	3222	9	with	with	IN
cord-001835-0s7ok4uw	3222	10	GFP1	GFP1	NNP
cord-001835-0s7ok4uw	3222	11	-	-	HYPH
cord-001835-0s7ok4uw	3222	12	9	9	CD
cord-001835-0s7ok4uw	3222	13	to	to	TO
cord-001835-0s7ok4uw	3222	14	reconstitute	reconstitute	VB
cord-001835-0s7ok4uw	3222	15	a	a	DT
cord-001835-0s7ok4uw	3222	16	functional	functional	JJ
cord-001835-0s7ok4uw	3222	17	GFP	gfp	NN
cord-001835-0s7ok4uw	3222	18	(	(	-LRB-
cord-001835-0s7ok4uw	3222	19	2	2	CD
cord-001835-0s7ok4uw	3222	20	)	)	-RRB-
cord-001835-0s7ok4uw	3222	21	.	.	.
cord-001835-0s7ok4uw	3223	1	Using	use	VBG
cord-001835-0s7ok4uw	3223	2	coiled	coil	VBN
cord-001835-0s7ok4uw	3223	3	-	-	HYPH
cord-001835-0s7ok4uw	3223	4	coils	coil	NNS
cord-001835-0s7ok4uw	3223	5	and	and	CC
cord-001835-0s7ok4uw	3223	6	FRB	FRB	NNP
cord-001835-0s7ok4uw	3223	7	/	/	SYM
cord-001835-0s7ok4uw	3223	8	FKBP12	FKBP12	NNP
cord-001835-0s7ok4uw	3223	9	model	model	NN
cord-001835-0s7ok4uw	3223	10	systems	system	NNS
cord-001835-0s7ok4uw	3223	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	3223	12	characterize	characterize	VBP
cord-001835-0s7ok4uw	3223	13	the	the	DT
cord-001835-0s7ok4uw	3223	14	sensor	sensor	NN
cord-001835-0s7ok4uw	3223	15	in	in	IN
cord-001835-0s7ok4uw	3223	16	vitro	vitro	FW
cord-001835-0s7ok4uw	3223	17	and	and	CC
cord-001835-0s7ok4uw	3223	18	in	in	IN
cord-001835-0s7ok4uw	3223	19	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	3223	20	coli	coli	NNS
cord-001835-0s7ok4uw	3223	21	.	.	.
cord-001835-0s7ok4uw	3224	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3224	2	extended	extend	VBD
cord-001835-0s7ok4uw	3224	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3224	4	studies	study	NNS
cord-001835-0s7ok4uw	3224	5	to	to	IN
cord-001835-0s7ok4uw	3224	6	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	3224	7	cells	cell	NNS
cord-001835-0s7ok4uw	3224	8	and	and	CC
cord-001835-0s7ok4uw	3224	9	examine	examine	VB
cord-001835-0s7ok4uw	3224	10	the	the	DT
cord-001835-0s7ok4uw	3224	11	FK-506	FK-506	NNP
cord-001835-0s7ok4uw	3224	12	inhibition	inhibition	NN
cord-001835-0s7ok4uw	3224	13	of	of	IN
cord-001835-0s7ok4uw	3224	14	the	the	DT
cord-001835-0s7ok4uw	3224	15	rapamycin	rapamycin	NN
cord-001835-0s7ok4uw	3224	16	-	-	HYPH
cord-001835-0s7ok4uw	3224	17	induced	induce	VBN
cord-001835-0s7ok4uw	3224	18	association	association	NN
cord-001835-0s7ok4uw	3224	19	of	of	IN
cord-001835-0s7ok4uw	3224	20	FRB	FRB	NNP
cord-001835-0s7ok4uw	3224	21	/	/	SYM
cord-001835-0s7ok4uw	3224	22	FKBP12	FKBP12	NNP
cord-001835-0s7ok4uw	3224	23	.	.	.
cord-001835-0s7ok4uw	3225	1	The	the	DT
cord-001835-0s7ok4uw	3225	2	small	small	JJ
cord-001835-0s7ok4uw	3225	3	size	size	NN
cord-001835-0s7ok4uw	3225	4	of	of	IN
cord-001835-0s7ok4uw	3225	5	these	these	DT
cord-001835-0s7ok4uw	3225	6	tags	tag	NNS
cord-001835-0s7ok4uw	3225	7	and	and	CC
cord-001835-0s7ok4uw	3225	8	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3225	9	minimal	minimal	JJ
cord-001835-0s7ok4uw	3225	10	effect	effect	NN
cord-001835-0s7ok4uw	3225	11	on	on	IN
cord-001835-0s7ok4uw	3225	12	fusion	fusion	NN
cord-001835-0s7ok4uw	3225	13	protein	protein	NN
cord-001835-0s7ok4uw	3225	14	behavior	behavior	NN
cord-001835-0s7ok4uw	3225	15	and	and	CC
cord-001835-0s7ok4uw	3225	16	solubility	solubility	NN
cord-001835-0s7ok4uw	3225	17	should	should	MD
cord-001835-0s7ok4uw	3225	18	enable	enable	VB
cord-001835-0s7ok4uw	3225	19	new	new	JJ
cord-001835-0s7ok4uw	3225	20	experiments	experiment	NNS
cord-001835-0s7ok4uw	3225	21	for	for	IN
cord-001835-0s7ok4uw	3225	22	monitoring	monitor	VBG
cord-001835-0s7ok4uw	3225	23	protein	protein	NN
cord-001835-0s7ok4uw	3225	24	-	-	HYPH
cord-001835-0s7ok4uw	3225	25	protein	protein	NN
cord-001835-0s7ok4uw	3225	26	association	association	NN
cord-001835-0s7ok4uw	3225	27	by	by	IN
cord-001835-0s7ok4uw	3225	28	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3225	29	and	and	CC
cord-001835-0s7ok4uw	3225	30	for	for	IN
cord-001835-0s7ok4uw	3225	31	screening	screen	VBG
cord-001835-0s7ok4uw	3225	32	modulators	modulator	NNS
cord-001835-0s7ok4uw	3225	33	of	of	IN
cord-001835-0s7ok4uw	3225	34	complex	complex	JJ
cord-001835-0s7ok4uw	3225	35	formation	formation	NN
cord-001835-0s7ok4uw	3225	36	in	in	IN
cord-001835-0s7ok4uw	3225	37	cell	cell	NN
cord-001835-0s7ok4uw	3225	38	-	-	HYPH
cord-001835-0s7ok4uw	3225	39	based	base	VBN
cord-001835-0s7ok4uw	3225	40	assays	assay	NNS
cord-001835-0s7ok4uw	3225	41	.	.	.
cord-001835-0s7ok4uw	3225	42	 	 	_SP
cord-001835-0s7ok4uw	3226	1	Aldehyde	Aldehyde	NNP
cord-001835-0s7ok4uw	3226	2	dehydrogenases	dehydrogenase	NNS
cord-001835-0s7ok4uw	3226	3	(	(	-LRB-
cord-001835-0s7ok4uw	3226	4	ALDHs	aldh	NNS
cord-001835-0s7ok4uw	3226	5	)	)	-RRB-
cord-001835-0s7ok4uw	3226	6	catalyze	catalyze	VBP
cord-001835-0s7ok4uw	3226	7	the	the	DT
cord-001835-0s7ok4uw	3226	8	oxidation	oxidation	NN
cord-001835-0s7ok4uw	3226	9	of	of	IN
cord-001835-0s7ok4uw	3226	10	aldehydes	aldehyde	NNS
cord-001835-0s7ok4uw	3226	11	to	to	IN
cord-001835-0s7ok4uw	3226	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3226	13	corresponding	corresponding	JJ
cord-001835-0s7ok4uw	3226	14	acids	acid	NNS
cord-001835-0s7ok4uw	3226	15	using	use	VBG
cord-001835-0s7ok4uw	3226	16	NAD(P)1	nad(p)1	RB
cord-001835-0s7ok4uw	3226	17	as	as	IN
cord-001835-0s7ok4uw	3226	18	coenzyme	coenzyme	NN
cord-001835-0s7ok4uw	3226	19	.	.	.
cord-001835-0s7ok4uw	3227	1	These	these	DT
cord-001835-0s7ok4uw	3227	2	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3227	3	are	be	VBP
cord-001835-0s7ok4uw	3227	4	responsible	responsible	JJ
cord-001835-0s7ok4uw	3227	5	for	for	IN
cord-001835-0s7ok4uw	3227	6	the	the	DT
cord-001835-0s7ok4uw	3227	7	detoxification	detoxification	NN
cord-001835-0s7ok4uw	3227	8	of	of	IN
cord-001835-0s7ok4uw	3227	9	lipid	lipid	JJ
cord-001835-0s7ok4uw	3227	10	peroxidation	peroxidation	NN
cord-001835-0s7ok4uw	3227	11	products	product	NNS
cord-001835-0s7ok4uw	3227	12	,	,	,
cord-001835-0s7ok4uw	3227	13	which	which	WDT
cord-001835-0s7ok4uw	3227	14	have	have	VBP
cord-001835-0s7ok4uw	3227	15	been	be	VBN
cord-001835-0s7ok4uw	3227	16	involved	involve	VBN
cord-001835-0s7ok4uw	3227	17	in	in	IN
cord-001835-0s7ok4uw	3227	18	the	the	DT
cord-001835-0s7ok4uw	3227	19	etiology	etiology	NN
cord-001835-0s7ok4uw	3227	20	and	and	CC
cord-001835-0s7ok4uw	3227	21	pathogenesis	pathogenesis	NN
cord-001835-0s7ok4uw	3227	22	of	of	IN
cord-001835-0s7ok4uw	3227	23	different	different	JJ
cord-001835-0s7ok4uw	3227	24	diseases	disease	NNS
cord-001835-0s7ok4uw	3227	25	involving	involve	VBG
cord-001835-0s7ok4uw	3227	26	increments	increment	NNS
cord-001835-0s7ok4uw	3227	27	in	in	IN
cord-001835-0s7ok4uw	3227	28	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	3227	29	stress	stress	NN
cord-001835-0s7ok4uw	3227	30	.	.	.
cord-001835-0s7ok4uw	3228	1	Recent	recent	JJ
cord-001835-0s7ok4uw	3228	2	data	datum	NNS
cord-001835-0s7ok4uw	3228	3	from	from	IN
cord-001835-0s7ok4uw	3228	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3228	5	group	group	NN
cord-001835-0s7ok4uw	3228	6	,	,	,
cord-001835-0s7ok4uw	3228	7	showed	show	VBD
cord-001835-0s7ok4uw	3228	8	that	that	IN
cord-001835-0s7ok4uw	3228	9	ALDH3A1	ALDH3A1	NNP
cord-001835-0s7ok4uw	3228	10	is	be	VBZ
cord-001835-0s7ok4uw	3228	11	resistant	resistant	JJ
cord-001835-0s7ok4uw	3228	12	to	to	IN
cord-001835-0s7ok4uw	3228	13	inactivation	inactivation	NN
cord-001835-0s7ok4uw	3228	14	by	by	IN
cord-001835-0s7ok4uw	3228	15	lipid	lipid	NN
cord-001835-0s7ok4uw	3228	16	peroxidation	peroxidation	NN
cord-001835-0s7ok4uw	3228	17	products	product	NNS
cord-001835-0s7ok4uw	3228	18	,	,	,
cord-001835-0s7ok4uw	3228	19	even	even	RB
cord-001835-0s7ok4uw	3228	20	at	at	IN
cord-001835-0s7ok4uw	3228	21	concentrations	concentration	NNS
cord-001835-0s7ok4uw	3228	22	50	50	CD
cord-001835-0s7ok4uw	3228	23	-	-	SYM
cord-001835-0s7ok4uw	3228	24	100	100	CD
cord-001835-0s7ok4uw	3228	25	times	time	NNS
cord-001835-0s7ok4uw	3228	26	higher	high	JJR
cord-001835-0s7ok4uw	3228	27	than	than	IN
cord-001835-0s7ok4uw	3228	28	those	those	DT
cord-001835-0s7ok4uw	3228	29	required	require	VBN
cord-001835-0s7ok4uw	3228	30	to	to	TO
cord-001835-0s7ok4uw	3228	31	inactivate	inactivate	VB
cord-001835-0s7ok4uw	3228	32	ALDH1A1	ALDH1A1	NNP
cord-001835-0s7ok4uw	3228	33	and	and	CC
cord-001835-0s7ok4uw	3228	34	ALDH2	ALDH2	NNP
cord-001835-0s7ok4uw	3228	35	.	.	.
cord-001835-0s7ok4uw	3229	1	The	the	DT
cord-001835-0s7ok4uw	3229	2	amino	amino	NN
cord-001835-0s7ok4uw	3229	3	acids	acid	NNS
cord-001835-0s7ok4uw	3229	4	sequence	sequence	NN
cord-001835-0s7ok4uw	3229	5	of	of	IN
cord-001835-0s7ok4uw	3229	6	the	the	DT
cord-001835-0s7ok4uw	3229	7	aldehyde	aldehyde	NN
cord-001835-0s7ok4uw	3229	8	-	-	HYPH
cord-001835-0s7ok4uw	3229	9	binding	bind	VBG
cord-001835-0s7ok4uw	3229	10	site	site	NN
cord-001835-0s7ok4uw	3229	11	of	of	IN
cord-001835-0s7ok4uw	3229	12	the	the	DT
cord-001835-0s7ok4uw	3229	13	three	three	CD
cord-001835-0s7ok4uw	3229	14	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3229	15	was	be	VBD
cord-001835-0s7ok4uw	3229	16	analyzed	analyze	VBN
cord-001835-0s7ok4uw	3229	17	,	,	,
cord-001835-0s7ok4uw	3229	18	and	and	CC
cord-001835-0s7ok4uw	3229	19	it	-PRON-	PRP
cord-001835-0s7ok4uw	3229	20	was	be	VBD
cord-001835-0s7ok4uw	3229	21	found	find	VBN
cord-001835-0s7ok4uw	3229	22	that	that	IN
cord-001835-0s7ok4uw	3229	23	the	the	DT
cord-001835-0s7ok4uw	3229	24	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3229	25	susceptible	susceptible	JJ
cord-001835-0s7ok4uw	3229	26	to	to	IN
cord-001835-0s7ok4uw	3229	27	the	the	DT
cord-001835-0s7ok4uw	3229	28	effect	effect	NN
cord-001835-0s7ok4uw	3229	29	of	of	IN
cord-001835-0s7ok4uw	3229	30	lipid	lipid	NN
cord-001835-0s7ok4uw	3229	31	peroxidation	peroxidation	NN
cord-001835-0s7ok4uw	3229	32	products	product	NNS
cord-001835-0s7ok4uw	3229	33	(	(	-LRB-
cord-001835-0s7ok4uw	3229	34	ALDH1A1	ALDH1A1	NNP
cord-001835-0s7ok4uw	3229	35	and	and	CC
cord-001835-0s7ok4uw	3229	36	ALDH2	ALDH2	NNP
cord-001835-0s7ok4uw	3229	37	)	)	-RRB-
cord-001835-0s7ok4uw	3229	38	,	,	,
cord-001835-0s7ok4uw	3229	39	have	have	VBP
cord-001835-0s7ok4uw	3229	40	Cys	Cys	NNP
cord-001835-0s7ok4uw	3229	41	residues	residue	NNS
cord-001835-0s7ok4uw	3229	42	flanking	flank	VBG
cord-001835-0s7ok4uw	3229	43	the	the	DT
cord-001835-0s7ok4uw	3229	44	reactive	reactive	JJ
cord-001835-0s7ok4uw	3229	45	Cys	Cys	NNP
cord-001835-0s7ok4uw	3229	46	(	(	-LRB-
cord-001835-0s7ok4uw	3229	47	position	position	NN
cord-001835-0s7ok4uw	3229	48	302	302	CD
cord-001835-0s7ok4uw	3229	49	)	)	-RRB-
cord-001835-0s7ok4uw	3229	50	,	,	,
cord-001835-0s7ok4uw	3229	51	based	base	VBN
cord-001835-0s7ok4uw	3229	52	on	on	IN
cord-001835-0s7ok4uw	3229	53	this	this	DT
cord-001835-0s7ok4uw	3229	54	criteria	criterion	NNS
cord-001835-0s7ok4uw	3229	55	and	and	CC
cord-001835-0s7ok4uw	3229	56	considering	consider	VBG
cord-001835-0s7ok4uw	3229	57	that	that	IN
cord-001835-0s7ok4uw	3229	58	these	these	DT
cord-001835-0s7ok4uw	3229	59	aldehydes	aldehyde	NNS
cord-001835-0s7ok4uw	3229	60	react	react	VBP
cord-001835-0s7ok4uw	3229	61	preferentially	preferentially	RB
cord-001835-0s7ok4uw	3229	62	with	with	IN
cord-001835-0s7ok4uw	3229	63	cysteine	cysteine	NN
cord-001835-0s7ok4uw	3229	64	,	,	,
cord-001835-0s7ok4uw	3229	65	a	a	DT
cord-001835-0s7ok4uw	3229	66	mutant	mutant	NN
cord-001835-0s7ok4uw	3229	67	of	of	IN
cord-001835-0s7ok4uw	3229	68	ALDH2	ALDH2	NNP
cord-001835-0s7ok4uw	3229	69	was	be	VBD
cord-001835-0s7ok4uw	3229	70	generated	generate	VBN
cord-001835-0s7ok4uw	3229	71	changing	change	VBG
cord-001835-0s7ok4uw	3229	72	the	the	DT
cord-001835-0s7ok4uw	3229	73	Cys	Cys	NNP
cord-001835-0s7ok4uw	3229	74	residues	residue	NNS
cord-001835-0s7ok4uw	3229	75	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	3229	76	to	to	IN
cord-001835-0s7ok4uw	3229	77	Cys302	cys302	CD
cord-001835-0s7ok4uw	3229	78	.	.	.
cord-001835-0s7ok4uw	3230	1	The	the	DT
cord-001835-0s7ok4uw	3230	2	mutant	mutant	JJ
cord-001835-0s7ok4uw	3230	3	ALDH2-Cys301Thr	ALDH2-Cys301Thr	NNP
cord-001835-0s7ok4uw	3230	4	-	-	HYPH
cord-001835-0s7ok4uw	3230	5	Cys303Val	Cys303Val	NNP
cord-001835-0s7ok4uw	3230	6	,	,	,
cord-001835-0s7ok4uw	3230	7	was	be	VBD
cord-001835-0s7ok4uw	3230	8	resistant	resistant	JJ
cord-001835-0s7ok4uw	3230	9	to	to	IN
cord-001835-0s7ok4uw	3230	10	the	the	DT
cord-001835-0s7ok4uw	3230	11	inactivation	inactivation	NN
cord-001835-0s7ok4uw	3230	12	by	by	IN
cord-001835-0s7ok4uw	3230	13	acrolein	acrolein	NN
cord-001835-0s7ok4uw	3230	14	and	and	CC
cord-001835-0s7ok4uw	3230	15	4-HNE	4-hne	CD
cord-001835-0s7ok4uw	3230	16	,	,	,
cord-001835-0s7ok4uw	3230	17	even	even	RB
cord-001835-0s7ok4uw	3230	18	at	at	IN
cord-001835-0s7ok4uw	3230	19	concentrations	concentration	NNS
cord-001835-0s7ok4uw	3230	20	1000-fold	1000-fold	CD
cord-001835-0s7ok4uw	3230	21	higher	high	JJR
cord-001835-0s7ok4uw	3230	22	than	than	IN
cord-001835-0s7ok4uw	3230	23	those	those	DT
cord-001835-0s7ok4uw	3230	24	required	require	VBN
cord-001835-0s7ok4uw	3230	25	to	to	TO
cord-001835-0s7ok4uw	3230	26	inactivate	inactivate	VB
cord-001835-0s7ok4uw	3230	27	ALDH2	ALDH2	NNP
cord-001835-0s7ok4uw	3230	28	.	.	.
cord-001835-0s7ok4uw	3231	1	However	however	RB
cord-001835-0s7ok4uw	3231	2	,	,	,
cord-001835-0s7ok4uw	3231	3	the	the	DT
cord-001835-0s7ok4uw	3231	4	mutant	mutant	JJ
cord-001835-0s7ok4uw	3231	5	presented	present	VBN
cord-001835-0s7ok4uw	3231	6	values	value	NNS
cord-001835-0s7ok4uw	3231	7	of	of	IN
cord-001835-0s7ok4uw	3231	8	Km	km	CD
cord-001835-0s7ok4uw	3231	9	2	2	CD
cord-001835-0s7ok4uw	3231	10	,	,	,
cord-001835-0s7ok4uw	3231	11	5	5	CD
cord-001835-0s7ok4uw	3231	12	and	and	CC
cord-001835-0s7ok4uw	3231	13	50-fold	50-fold	JJ
cord-001835-0s7ok4uw	3231	14	higher	high	JJR
cord-001835-0s7ok4uw	3231	15	for	for	IN
cord-001835-0s7ok4uw	3231	16	acrolein	acrolein	NN
cord-001835-0s7ok4uw	3231	17	,	,	,
cord-001835-0s7ok4uw	3231	18	propionaldehyde	propionaldehyde	NNP
cord-001835-0s7ok4uw	3231	19	and	and	CC
cord-001835-0s7ok4uw	3231	20	acetaldehyde	acetaldehyde	NN
cord-001835-0s7ok4uw	3231	21	,	,	,
cord-001835-0s7ok4uw	3231	22	respectively	respectively	RB
cord-001835-0s7ok4uw	3231	23	,	,	,
cord-001835-0s7ok4uw	3231	24	compared	compare	VBN
cord-001835-0s7ok4uw	3231	25	to	to	IN
cord-001835-0s7ok4uw	3231	26	the	the	DT
cord-001835-0s7ok4uw	3231	27	wild	wild	JJ
cord-001835-0s7ok4uw	3231	28	type	type	NN
cord-001835-0s7ok4uw	3231	29	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3231	30	,	,	,
cord-001835-0s7ok4uw	3231	31	but	but	CC
cord-001835-0s7ok4uw	3231	32	showed	show	VBD
cord-001835-0s7ok4uw	3231	33	a	a	DT
cord-001835-0s7ok4uw	3231	34	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3231	35	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3231	36	similar	similar	JJ
cord-001835-0s7ok4uw	3231	37	to	to	IN
cord-001835-0s7ok4uw	3231	38	the	the	DT
cord-001835-0s7ok4uw	3231	39	parent	parent	NN
cord-001835-0s7ok4uw	3231	40	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3231	41	.	.	.
cord-001835-0s7ok4uw	3232	1	These	these	DT
cord-001835-0s7ok4uw	3232	2	data	datum	NNS
cord-001835-0s7ok4uw	3232	3	revealed	reveal	VBD
cord-001835-0s7ok4uw	3232	4	that	that	IN
cord-001835-0s7ok4uw	3232	5	Cys	Cys	NNP
cord-001835-0s7ok4uw	3232	6	residues	residue	NNS
cord-001835-0s7ok4uw	3232	7	near	near	RB
cord-001835-0s7ok4uw	3232	8	to	to	IN
cord-001835-0s7ok4uw	3232	9	the	the	DT
cord-001835-0s7ok4uw	3232	10	reactive	reactive	JJ
cord-001835-0s7ok4uw	3232	11	Cys	Cys	NNP
cord-001835-0s7ok4uw	3232	12	in	in	IN
cord-001835-0s7ok4uw	3232	13	ALDH2	ALDH2	NNP
cord-001835-0s7ok4uw	3232	14	are	be	VBP
cord-001835-0s7ok4uw	3232	15	important	important	JJ
cord-001835-0s7ok4uw	3232	16	in	in	IN
cord-001835-0s7ok4uw	3232	17	the	the	DT
cord-001835-0s7ok4uw	3232	18	inactivation	inactivation	NN
cord-001835-0s7ok4uw	3232	19	process	process	NN
cord-001835-0s7ok4uw	3232	20	induced	induce	VBN
cord-001835-0s7ok4uw	3232	21	by	by	IN
cord-001835-0s7ok4uw	3232	22	lipid	lipid	NN
cord-001835-0s7ok4uw	3232	23	aldehydes	aldehyde	NNS
cord-001835-0s7ok4uw	3232	24	,	,	,
cord-001835-0s7ok4uw	3232	25	but	but	CC
cord-001835-0s7ok4uw	3232	26	also	also	RB
cord-001835-0s7ok4uw	3232	27	participate	participate	VB
cord-001835-0s7ok4uw	3232	28	in	in	IN
cord-001835-0s7ok4uw	3232	29	determining	determine	VBG
cord-001835-0s7ok4uw	3232	30	the	the	DT
cord-001835-0s7ok4uw	3232	31	specificity	specificity	NN
cord-001835-0s7ok4uw	3232	32	for	for	IN
cord-001835-0s7ok4uw	3232	33	the	the	DT
cord-001835-0s7ok4uw	3232	34	substrates	substrate	NNS
cord-001835-0s7ok4uw	3232	35	in	in	IN
cord-001835-0s7ok4uw	3232	36	this	this	DT
cord-001835-0s7ok4uw	3232	37	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3232	38	.	.	.
cord-001835-0s7ok4uw	3233	1	Small	small	JJ
cord-001835-0s7ok4uw	3233	2	molecule	molecule	NN
cord-001835-0s7ok4uw	3233	3	-	-	HYPH
cord-001835-0s7ok4uw	3233	4	assisted	assist	VBN
cord-001835-0s7ok4uw	3233	5	shutoff	shutoff	NN
cord-001835-0s7ok4uw	3233	6	:	:	:
cord-001835-0s7ok4uw	3233	7	A	a	DT
cord-001835-0s7ok4uw	3233	8	widely	widely	RB
cord-001835-0s7ok4uw	3233	9	applicable	applicable	JJ
cord-001835-0s7ok4uw	3233	10	method	method	NN
cord-001835-0s7ok4uw	3233	11	for	for	IN
cord-001835-0s7ok4uw	3233	12	tunable	tunable	JJ
cord-001835-0s7ok4uw	3233	13	and	and	CC
cord-001835-0s7ok4uw	3233	14	reversible	reversible	JJ
cord-001835-0s7ok4uw	3233	15	control	control	NN
cord-001835-0s7ok4uw	3233	16	of	of	IN
cord-001835-0s7ok4uw	3233	17	protein	protein	NN
cord-001835-0s7ok4uw	3233	18	production	production	NN
cord-001835-0s7ok4uw	3233	19	H.	H.	NNP
cord-001835-0s7ok4uw	3233	20	Kay	Kay	NNP
cord-001835-0s7ok4uw	3233	21	Chung	Chung	NNP
cord-001835-0s7ok4uw	3233	22	1	1	CD
cord-001835-0s7ok4uw	3233	23	,	,	,
cord-001835-0s7ok4uw	3233	24	Conor	Conor	NNP
cord-001835-0s7ok4uw	3233	25	Jacobs	Jacobs	NNP
cord-001835-0s7ok4uw	3233	26	1	1	CD
cord-001835-0s7ok4uw	3233	27	,	,	,
cord-001835-0s7ok4uw	3233	28	Yunwen	Yunwen	NNP
cord-001835-0s7ok4uw	3233	29	Huo	Huo	NNP
cord-001835-0s7ok4uw	3233	30	2	2	CD
cord-001835-0s7ok4uw	3233	31	,	,	,
cord-001835-0s7ok4uw	3233	32	Jin	Jin	NNP
cord-001835-0s7ok4uw	3233	33	Yang	Yang	NNP
cord-001835-0s7ok4uw	3233	34	3	3	CD
cord-001835-0s7ok4uw	3233	35	,	,	,
cord-001835-0s7ok4uw	3233	36	Stefanie	Stefanie	NNP
cord-001835-0s7ok4uw	3233	37	Krumm	Krumm	NNP
cord-001835-0s7ok4uw	3233	38	4	4	CD
cord-001835-0s7ok4uw	3233	39	,	,	,
cord-001835-0s7ok4uw	3233	40	Richard	Richard	NNP
cord-001835-0s7ok4uw	3233	41	Plemper	Plemper	NNP
cord-001835-0s7ok4uw	3233	42	4,5	4,5	CD
cord-001835-0s7ok4uw	3233	43	,	,	,
cord-001835-0s7ok4uw	3233	44	Roger	Roger	NNP
cord-001835-0s7ok4uw	3233	45	Tsien	Tsien	NNP
cord-001835-0s7ok4uw	3233	46	0	0	CD
cord-001835-0s7ok4uw	3234	1	,	,	,
cord-001835-0s7ok4uw	3234	2	Michael	Michael	NNP
cord-001835-0s7ok4uw	3234	3	Lin	Lin	NNP
cord-001835-0s7ok4uw	3234	4	3	3	CD
cord-001835-0s7ok4uw	3234	5	1	1	CD
cord-001835-0s7ok4uw	3234	6	Department	Department	NNP
cord-001835-0s7ok4uw	3234	7	of	of	IN
cord-001835-0s7ok4uw	3234	8	Biology	Biology	NNP
cord-001835-0s7ok4uw	3234	9	,	,	,
cord-001835-0s7ok4uw	3234	10	Stanford	Stanford	NNP
cord-001835-0s7ok4uw	3234	11	University	University	NNP
cord-001835-0s7ok4uw	3234	12	,	,	,
cord-001835-0s7ok4uw	3234	13	2	2	CD
cord-001835-0s7ok4uw	3234	14	Department	Department	NNP
cord-001835-0s7ok4uw	3234	15	of	of	IN
cord-001835-0s7ok4uw	3234	16	Pediatrics	Pediatrics	NNP
cord-001835-0s7ok4uw	3234	17	,	,	,
cord-001835-0s7ok4uw	3234	18	Stanford	Stanford	NNP
cord-001835-0s7ok4uw	3234	19	University	University	NNP
cord-001835-0s7ok4uw	3234	20	,	,	,
cord-001835-0s7ok4uw	3234	21	3	3	CD
cord-001835-0s7ok4uw	3234	22	Department	Department	NNP
cord-001835-0s7ok4uw	3234	23	of	of	IN
cord-001835-0s7ok4uw	3234	24	Pharmacology	Pharmacology	NNP
cord-001835-0s7ok4uw	3234	25	,	,	,
cord-001835-0s7ok4uw	3234	26	University	University	NNP
cord-001835-0s7ok4uw	3234	27	of	of	IN
cord-001835-0s7ok4uw	3234	28	California	California	NNP
cord-001835-0s7ok4uw	3234	29	San	San	NNP
cord-001835-0s7ok4uw	3234	30	Diego	Diego	NNP
cord-001835-0s7ok4uw	3234	31	,	,	,
cord-001835-0s7ok4uw	3234	32	4	4	CD
cord-001835-0s7ok4uw	3234	33	Department	Department	NNP
cord-001835-0s7ok4uw	3234	34	of	of	IN
cord-001835-0s7ok4uw	3234	35	Pediatrics	Pediatrics	NNP
cord-001835-0s7ok4uw	3234	36	,	,	,
cord-001835-0s7ok4uw	3234	37	Emory	Emory	NNP
cord-001835-0s7ok4uw	3234	38	University	University	NNP
cord-001835-0s7ok4uw	3234	39	,	,	,
cord-001835-0s7ok4uw	3234	40	5	5	CD
cord-001835-0s7ok4uw	3234	41	Institute	Institute	NNP
cord-001835-0s7ok4uw	3234	42	for	for	IN
cord-001835-0s7ok4uw	3234	43	Biomedical	Biomedical	NNP
cord-001835-0s7ok4uw	3234	44	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	3234	45	,	,	,
cord-001835-0s7ok4uw	3234	46	Georgia	Georgia	NNP
cord-001835-0s7ok4uw	3234	47	State	State	NNP
cord-001835-0s7ok4uw	3234	48	University	University	NNP
cord-001835-0s7ok4uw	3234	49	,	,	,
cord-001835-0s7ok4uw	3234	50	6	6	CD
cord-001835-0s7ok4uw	3234	51	Department	Department	NNP
cord-001835-0s7ok4uw	3234	52	of	of	IN
cord-001835-0s7ok4uw	3234	53	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	3234	54	and	and	CC
cord-001835-0s7ok4uw	3234	55	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	3234	56	,	,	,
cord-001835-0s7ok4uw	3234	57	University	University	NNP
cord-001835-0s7ok4uw	3234	58	of	of	IN
cord-001835-0s7ok4uw	3234	59	California	California	NNP
cord-001835-0s7ok4uw	3234	60	San	San	NNP
cord-001835-0s7ok4uw	3234	61	Diego	Diego	NNP
cord-001835-0s7ok4uw	3234	62	,	,	,
cord-001835-0s7ok4uw	3234	63	7	7	CD
cord-001835-0s7ok4uw	3234	64	Howard	Howard	NNP
cord-001835-0s7ok4uw	3234	65	Hughes	Hughes	NNP
cord-001835-0s7ok4uw	3234	66	Medical	Medical	NNP
cord-001835-0s7ok4uw	3234	67	Institute	Institute	NNP
cord-001835-0s7ok4uw	3234	68	,	,	,
cord-001835-0s7ok4uw	3234	69	University	University	NNP
cord-001835-0s7ok4uw	3234	70	of	of	IN
cord-001835-0s7ok4uw	3234	71	California	California	NNP
cord-001835-0s7ok4uw	3234	72	San	San	NNP
cord-001835-0s7ok4uw	3234	73	Diego	Diego	NNP
cord-001835-0s7ok4uw	3234	74	,	,	,
cord-001835-0s7ok4uw	3235	1	8	8	CD
cord-001835-0s7ok4uw	3235	2	 	 	_SP
cord-001835-0s7ok4uw	3236	1	The	the	DT
cord-001835-0s7ok4uw	3236	2	ability	ability	NN
cord-001835-0s7ok4uw	3236	3	to	to	TO
cord-001835-0s7ok4uw	3236	4	quickly	quickly	RB
cord-001835-0s7ok4uw	3236	5	control	control	VB
cord-001835-0s7ok4uw	3236	6	the	the	DT
cord-001835-0s7ok4uw	3236	7	production	production	NN
cord-001835-0s7ok4uw	3236	8	of	of	IN
cord-001835-0s7ok4uw	3236	9	specific	specific	JJ
cord-001835-0s7ok4uw	3236	10	proteins	protein	NNS
cord-001835-0s7ok4uw	3236	11	would	would	MD
cord-001835-0s7ok4uw	3236	12	be	be	VB
cord-001835-0s7ok4uw	3236	13	useful	useful	JJ
cord-001835-0s7ok4uw	3236	14	in	in	IN
cord-001835-0s7ok4uw	3236	15	biomedical	biomedical	JJ
cord-001835-0s7ok4uw	3236	16	research	research	NN
cord-001835-0s7ok4uw	3236	17	and	and	CC
cord-001835-0s7ok4uw	3236	18	biotechnology	biotechnology	NN
cord-001835-0s7ok4uw	3236	19	.	.	.
cord-001835-0s7ok4uw	3237	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3237	2	describe	describe	VBP
cord-001835-0s7ok4uw	3238	1	Small	Small	NNP
cord-001835-0s7ok4uw	3238	2	Molecule	Molecule	NNP
cord-001835-0s7ok4uw	3238	3	-	-	HYPH
cord-001835-0s7ok4uw	3238	4	Assisted	Assisted	NNP
cord-001835-0s7ok4uw	3238	5	Shutoff	Shutoff	NNP
cord-001835-0s7ok4uw	3238	6	(	(	-LRB-
cord-001835-0s7ok4uw	3238	7	SMASh	SMASh	NNPS
cord-001835-0s7ok4uw	3238	8	)	)	-RRB-
cord-001835-0s7ok4uw	3238	9	,	,	,
cord-001835-0s7ok4uw	3238	10	a	a	DT
cord-001835-0s7ok4uw	3238	11	technique	technique	NN
cord-001835-0s7ok4uw	3238	12	in	in	IN
cord-001835-0s7ok4uw	3238	13	which	which	WDT
cord-001835-0s7ok4uw	3238	14	proteins	protein	NNS
cord-001835-0s7ok4uw	3238	15	are	be	VBP
cord-001835-0s7ok4uw	3238	16	fused	fuse	VBN
cord-001835-0s7ok4uw	3238	17	to	to	IN
cord-001835-0s7ok4uw	3238	18	a	a	DT
cord-001835-0s7ok4uw	3238	19	self	self	NN
cord-001835-0s7ok4uw	3238	20	-	-	HYPH
cord-001835-0s7ok4uw	3238	21	excising	excise	VBG
cord-001835-0s7ok4uw	3238	22	degron	degron	NN
cord-001835-0s7ok4uw	3238	23	and	and	CC
cord-001835-0s7ok4uw	3238	24	thereby	thereby	RB
cord-001835-0s7ok4uw	3238	25	expressed	express	VBN
cord-001835-0s7ok4uw	3238	26	in	in	IN
cord-001835-0s7ok4uw	3238	27	a	a	DT
cord-001835-0s7ok4uw	3238	28	minimally	minimally	RB
cord-001835-0s7ok4uw	3238	29	modified	modify	VBN
cord-001835-0s7ok4uw	3238	30	form	form	NN
cord-001835-0s7ok4uw	3238	31	by	by	IN
cord-001835-0s7ok4uw	3238	32	default	default	NN
cord-001835-0s7ok4uw	3238	33	.	.	.
cord-001835-0s7ok4uw	3239	1	Degron	Degron	NNP
cord-001835-0s7ok4uw	3239	2	removal	removal	NN
cord-001835-0s7ok4uw	3239	3	is	be	VBZ
cord-001835-0s7ok4uw	3239	4	performed	perform	VBN
cord-001835-0s7ok4uw	3239	5	by	by	IN
cord-001835-0s7ok4uw	3239	6	a	a	DT
cord-001835-0s7ok4uw	3239	7	cis	cis	NNP
cord-001835-0s7ok4uw	3239	8	-	-	HYPH
cord-001835-0s7ok4uw	3239	9	encoded	encode	VBN
cord-001835-0s7ok4uw	3239	10	hepatitis	hepatitis	NN
cord-001835-0s7ok4uw	3239	11	C	c	NN
cord-001835-0s7ok4uw	3239	12	virus	virus	NN
cord-001835-0s7ok4uw	3239	13	(	(	-LRB-
cord-001835-0s7ok4uw	3239	14	HCV	HCV	NNP
cord-001835-0s7ok4uw	3239	15	)	)	-RRB-
cord-001835-0s7ok4uw	3239	16	protease	protease	NN
cord-001835-0s7ok4uw	3239	17	,	,	,
cord-001835-0s7ok4uw	3239	18	so	so	IN
cord-001835-0s7ok4uw	3239	19	that	that	IN
cord-001835-0s7ok4uw	3239	20	applying	apply	VBG
cord-001835-0s7ok4uw	3239	21	clinically	clinically	RB
cord-001835-0s7ok4uw	3239	22	available	available	JJ
cord-001835-0s7ok4uw	3239	23	HCV	HCV	NNP
cord-001835-0s7ok4uw	3239	24	protease	protease	NN
cord-001835-0s7ok4uw	3239	25	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	3239	26	causes	cause	VBZ
cord-001835-0s7ok4uw	3239	27	degron	degron	NNP
cord-001835-0s7ok4uw	3239	28	retention	retention	NN
cord-001835-0s7ok4uw	3239	29	on	on	IN
cord-001835-0s7ok4uw	3239	30	subsequently	subsequently	RB
cord-001835-0s7ok4uw	3239	31	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	3239	32	protein	protein	NN
cord-001835-0s7ok4uw	3239	33	copies	copy	NNS
cord-001835-0s7ok4uw	3239	34	and	and	CC
cord-001835-0s7ok4uw	3239	35	suppresses	suppress	VBZ
cord-001835-0s7ok4uw	3239	36	further	further	JJ
cord-001835-0s7ok4uw	3239	37	protein	protein	NN
cord-001835-0s7ok4uw	3239	38	production	production	NN
cord-001835-0s7ok4uw	3239	39	.	.	.
cord-001835-0s7ok4uw	3240	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3240	2	find	find	VBP
cord-001835-0s7ok4uw	3240	3	that	that	IN
cord-001835-0s7ok4uw	3240	4	SMASh	SMASh	NNS
cord-001835-0s7ok4uw	3240	5	allows	allow	VBZ
cord-001835-0s7ok4uw	3240	6	reversible	reversible	JJ
cord-001835-0s7ok4uw	3240	7	and	and	CC
cord-001835-0s7ok4uw	3240	8	dosedependent	dosedependent	JJ
cord-001835-0s7ok4uw	3240	9	shutoff	shutoff	NN
cord-001835-0s7ok4uw	3240	10	of	of	IN
cord-001835-0s7ok4uw	3240	11	various	various	JJ
cord-001835-0s7ok4uw	3240	12	proteins	protein	NNS
cord-001835-0s7ok4uw	3240	13	with	with	IN
cord-001835-0s7ok4uw	3240	14	high	high	JJ
cord-001835-0s7ok4uw	3240	15	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	3240	16	range	range	NN
cord-001835-0s7ok4uw	3240	17	in	in	IN
cord-001835-0s7ok4uw	3240	18	multiple	multiple	JJ
cord-001835-0s7ok4uw	3240	19	cell	cell	NN
cord-001835-0s7ok4uw	3240	20	types	type	NNS
cord-001835-0s7ok4uw	3240	21	,	,	,
cord-001835-0s7ok4uw	3240	22	including	include	VBG
cord-001835-0s7ok4uw	3240	23	yeast	yeast	NN
cord-001835-0s7ok4uw	3240	24	.	.	.
cord-001835-0s7ok4uw	3241	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3241	2	also	also	RB
cord-001835-0s7ok4uw	3241	3	successfully	successfully	RB
cord-001835-0s7ok4uw	3241	4	use	use	VBP
cord-001835-0s7ok4uw	3241	5	SMASh	SMASh	NNS
cord-001835-0s7ok4uw	3241	6	to	to	TO
cord-001835-0s7ok4uw	3241	7	confer	confer	VB
cord-001835-0s7ok4uw	3241	8	drug	drug	NN
cord-001835-0s7ok4uw	3241	9	responsiveness	responsiveness	NN
cord-001835-0s7ok4uw	3241	10	onto	onto	IN
cord-001835-0s7ok4uw	3241	11	a	a	DT
cord-001835-0s7ok4uw	3241	12	RNA	RNA	NNP
cord-001835-0s7ok4uw	3241	13	virus	virus	NN
cord-001835-0s7ok4uw	3241	14	for	for	IN
cord-001835-0s7ok4uw	3241	15	which	which	WDT
cord-001835-0s7ok4uw	3241	16	no	no	DT
cord-001835-0s7ok4uw	3241	17	licensed	license	VBN
cord-001835-0s7ok4uw	3241	18	drug	drug	NN
cord-001835-0s7ok4uw	3241	19	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	3241	20	exist	exist	VBP
cord-001835-0s7ok4uw	3241	21	.	.	.
cord-001835-0s7ok4uw	3242	1	As	as	IN
cord-001835-0s7ok4uw	3242	2	SMASh	SMASh	NNS
cord-001835-0s7ok4uw	3242	3	does	do	VBZ
cord-001835-0s7ok4uw	3242	4	not	not	RB
cord-001835-0s7ok4uw	3242	5	require	require	VB
cord-001835-0s7ok4uw	3242	6	permanent	permanent	JJ
cord-001835-0s7ok4uw	3242	7	fusion	fusion	NN
cord-001835-0s7ok4uw	3242	8	of	of	IN
cord-001835-0s7ok4uw	3242	9	a	a	DT
cord-001835-0s7ok4uw	3242	10	large	large	JJ
cord-001835-0s7ok4uw	3242	11	domain	domain	NN
cord-001835-0s7ok4uw	3242	12	,	,	,
cord-001835-0s7ok4uw	3242	13	it	-PRON-	PRP
cord-001835-0s7ok4uw	3242	14	should	should	MD
cord-001835-0s7ok4uw	3242	15	be	be	VB
cord-001835-0s7ok4uw	3242	16	useful	useful	JJ
cord-001835-0s7ok4uw	3242	17	when	when	WRB
cord-001835-0s7ok4uw	3242	18	control	control	NN
cord-001835-0s7ok4uw	3242	19	over	over	IN
cord-001835-0s7ok4uw	3242	20	protein	protein	NN
cord-001835-0s7ok4uw	3242	21	production	production	NN
cord-001835-0s7ok4uw	3242	22	with	with	IN
cord-001835-0s7ok4uw	3242	23	minimal	minimal	JJ
cord-001835-0s7ok4uw	3242	24	structural	structural	JJ
cord-001835-0s7ok4uw	3242	25	modification	modification	NN
cord-001835-0s7ok4uw	3242	26	is	be	VBZ
cord-001835-0s7ok4uw	3242	27	desired	desire	VBN
cord-001835-0s7ok4uw	3242	28	.	.	.
cord-001835-0s7ok4uw	3243	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	3243	2	,	,	,
cord-001835-0s7ok4uw	3243	3	as	as	IN
cord-001835-0s7ok4uw	3243	4	SMASh	SMASh	NNS
cord-001835-0s7ok4uw	3243	5	only	only	RB
cord-001835-0s7ok4uw	3243	6	uses	use	VBZ
cord-001835-0s7ok4uw	3243	7	a	a	DT
cord-001835-0s7ok4uw	3243	8	single	single	JJ
cord-001835-0s7ok4uw	3243	9	tag	tag	NN
cord-001835-0s7ok4uw	3243	10	and	and	CC
cord-001835-0s7ok4uw	3243	11	does	do	VBZ
cord-001835-0s7ok4uw	3243	12	not	not	RB
cord-001835-0s7ok4uw	3243	13	rely	rely	VB
cord-001835-0s7ok4uw	3243	14	on	on	IN
cord-001835-0s7ok4uw	3243	15	modulating	modulate	VBG
cord-001835-0s7ok4uw	3243	16	protein	protein	NN
cord-001835-0s7ok4uw	3243	17	-	-	HYPH
cord-001835-0s7ok4uw	3243	18	protein	protein	NN
cord-001835-0s7ok4uw	3243	19	interactions	interaction	NNS
cord-001835-0s7ok4uw	3243	20	,	,	,
cord-001835-0s7ok4uw	3243	21	it	-PRON-	PRP
cord-001835-0s7ok4uw	3243	22	should	should	MD
cord-001835-0s7ok4uw	3243	23	be	be	VB
cord-001835-0s7ok4uw	3243	24	easy	easy	JJ
cord-001835-0s7ok4uw	3243	25	to	to	TO
cord-001835-0s7ok4uw	3243	26	generalize	generalize	VB
cord-001835-0s7ok4uw	3243	27	to	to	IN
cord-001835-0s7ok4uw	3243	28	multiple	multiple	JJ
cord-001835-0s7ok4uw	3243	29	biological	biological	JJ
cord-001835-0s7ok4uw	3243	30	contexts	context	NNS
cord-001835-0s7ok4uw	3243	31	.	.	.
cord-001835-0s7ok4uw	3244	1	Top	Top	NNP
cord-001835-0s7ok4uw	3244	2	,	,	,
cord-001835-0s7ok4uw	3244	3	a	a	DT
cord-001835-0s7ok4uw	3244	4	protein	protein	NN
cord-001835-0s7ok4uw	3244	5	of	of	IN
cord-001835-0s7ok4uw	3244	6	interest	interest	NN
cord-001835-0s7ok4uw	3244	7	is	be	VBZ
cord-001835-0s7ok4uw	3244	8	fused	fuse	VBN
cord-001835-0s7ok4uw	3244	9	to	to	IN
cord-001835-0s7ok4uw	3244	10	the	the	DT
cord-001835-0s7ok4uw	3244	11	SMASh	SMASh	NNS
cord-001835-0s7ok4uw	3244	12	tag	tag	NN
cord-001835-0s7ok4uw	3244	13	via	via	IN
cord-001835-0s7ok4uw	3244	14	a	a	DT
cord-001835-0s7ok4uw	3244	15	HCV	HCV	NNP
cord-001835-0s7ok4uw	3244	16	NS3	ns3	RB
cord-001835-0s7ok4uw	3244	17	protease	protease	NN
cord-001835-0s7ok4uw	3244	18	recognition	recognition	NN
cord-001835-0s7ok4uw	3244	19	site	site	NN
cord-001835-0s7ok4uw	3244	20	.	.	.
cord-001835-0s7ok4uw	3245	1	After	after	IN
cord-001835-0s7ok4uw	3245	2	protein	protein	NN
cord-001835-0s7ok4uw	3245	3	folding	folding	NN
cord-001835-0s7ok4uw	3245	4	,	,	,
cord-001835-0s7ok4uw	3245	5	the	the	DT
cord-001835-0s7ok4uw	3245	6	SMASh	SMASh	NNS
cord-001835-0s7ok4uw	3245	7	tag	tag	NN
cord-001835-0s7ok4uw	3245	8	is	be	VBZ
cord-001835-0s7ok4uw	3245	9	removed	remove	VBN
cord-001835-0s7ok4uw	3245	10	by	by	IN
cord-001835-0s7ok4uw	3245	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3245	12	internal	internal	JJ
cord-001835-0s7ok4uw	3245	13	NS3	ns3	JJ
cord-001835-0s7ok4uw	3245	14	protease	protease	NN
cord-001835-0s7ok4uw	3245	15	activity	activity	NN
cord-001835-0s7ok4uw	3245	16	,	,	,
cord-001835-0s7ok4uw	3245	17	and	and	CC
cord-001835-0s7ok4uw	3245	18	is	be	VBZ
cord-001835-0s7ok4uw	3245	19	degraded	degrade	VBN
cord-001835-0s7ok4uw	3245	20	due	due	IN
cord-001835-0s7ok4uw	3245	21	to	to	IN
cord-001835-0s7ok4uw	3245	22	an	an	DT
cord-001835-0s7ok4uw	3245	23	internal	internal	JJ
cord-001835-0s7ok4uw	3245	24	degron	degron	NNP
cord-001835-0s7ok4uw	3245	25	activity	activity	NN
cord-001835-0s7ok4uw	3245	26	.	.	.
cord-001835-0s7ok4uw	3246	1	Bottom	bottom	JJ
cord-001835-0s7ok4uw	3246	2	,	,	,
cord-001835-0s7ok4uw	3246	3	addition	addition	NN
cord-001835-0s7ok4uw	3246	4	of	of	IN
cord-001835-0s7ok4uw	3246	5	protease	protease	NN
cord-001835-0s7ok4uw	3246	6	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	3246	7	induces	induce	VBZ
cord-001835-0s7ok4uw	3246	8	the	the	DT
cord-001835-0s7ok4uw	3246	9	rapid	rapid	JJ
cord-001835-0s7ok4uw	3246	10	degradation	degradation	NN
cord-001835-0s7ok4uw	3246	11	of	of	IN
cord-001835-0s7ok4uw	3246	12	subsequently	subsequently	RB
cord-001835-0s7ok4uw	3246	13	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	3246	14	copies	copy	NNS
cord-001835-0s7ok4uw	3246	15	of	of	IN
cord-001835-0s7ok4uw	3246	16	the	the	DT
cord-001835-0s7ok4uw	3246	17	tagged	tagged	NNP
cord-001835-0s7ok4uw	3246	18	protein	protein	NN
cord-001835-0s7ok4uw	3246	19	,	,	,
cord-001835-0s7ok4uw	3246	20	effectively	effectively	RB
cord-001835-0s7ok4uw	3246	21	shutting	shut	VBG
cord-001835-0s7ok4uw	3246	22	off	off	RP
cord-001835-0s7ok4uw	3246	23	further	further	JJ
cord-001835-0s7ok4uw	3246	24	protein	protein	NN
cord-001835-0s7ok4uw	3246	25	production	production	NN
cord-001835-0s7ok4uw	3246	26	.	.	.
cord-001835-0s7ok4uw	3247	1	vaccine	vaccine	NN
cord-001835-0s7ok4uw	3247	2	development	development	NN
cord-001835-0s7ok4uw	3247	3	has	have	VBZ
cord-001835-0s7ok4uw	3247	4	emerged	emerge	VBN
cord-001835-0s7ok4uw	3247	5	,	,	,
cord-001835-0s7ok4uw	3247	6	epitope	epitope	NN
cord-001835-0s7ok4uw	3247	7	-	-	HYPH
cord-001835-0s7ok4uw	3247	8	focused	focus	VBN
cord-001835-0s7ok4uw	3247	9	immunogens	immunogen	NNS
cord-001835-0s7ok4uw	3247	10	,	,	,
cord-001835-0s7ok4uw	3247	11	but	but	CC
cord-001835-0s7ok4uw	3247	12	in	in	IN
cord-001835-0s7ok4uw	3247	13	the	the	DT
cord-001835-0s7ok4uw	3247	14	past	past	NN
cord-001835-0s7ok4uw	3247	15	these	these	DT
cord-001835-0s7ok4uw	3247	16	have	have	VBP
cord-001835-0s7ok4uw	3247	17	failed	fail	VBN
cord-001835-0s7ok4uw	3247	18	to	to	TO
cord-001835-0s7ok4uw	3247	19	deliver	deliver	VB
cord-001835-0s7ok4uw	3247	20	the	the	DT
cord-001835-0s7ok4uw	3247	21	expected	expect	VBN
cord-001835-0s7ok4uw	3247	22	outcome	outcome	NN
cord-001835-0s7ok4uw	3247	23	.	.	.
cord-001835-0s7ok4uw	3248	1	Here	here	RB
cord-001835-0s7ok4uw	3248	2	,	,	,
cord-001835-0s7ok4uw	3248	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3248	4	employed	employ	VBD
cord-001835-0s7ok4uw	3248	5	a	a	DT
cord-001835-0s7ok4uw	3248	6	new	new	JJ
cord-001835-0s7ok4uw	3248	7	computational	computational	JJ
cord-001835-0s7ok4uw	3248	8	design	design	NN
cord-001835-0s7ok4uw	3248	9	methodology	methodology	NN
cord-001835-0s7ok4uw	3248	10	(	(	-LRB-
cord-001835-0s7ok4uw	3248	11	Rosetta	Rosetta	NNP
cord-001835-0s7ok4uw	3248	12	Fold	Fold	NNP
cord-001835-0s7ok4uw	3248	13	From	from	IN
cord-001835-0s7ok4uw	3248	14	Loops	Loops	NNP
cord-001835-0s7ok4uw	3248	15	or	or	CC
cord-001835-0s7ok4uw	3248	16	FFL	FFL	NNP
cord-001835-0s7ok4uw	3248	17	)	)	-RRB-
cord-001835-0s7ok4uw	3248	18	to	to	TO
cord-001835-0s7ok4uw	3248	19	design	design	VB
cord-001835-0s7ok4uw	3248	20	epitope	epitope	NN
cord-001835-0s7ok4uw	3248	21	-	-	HYPH
cord-001835-0s7ok4uw	3248	22	focused	focus	VBN
cord-001835-0s7ok4uw	3248	23	immunogens	immunogen	NNS
cord-001835-0s7ok4uw	3248	24	.	.	.
cord-001835-0s7ok4uw	3249	1	FFL	FFL	NNP
cord-001835-0s7ok4uw	3249	2	was	be	VBD
cord-001835-0s7ok4uw	3249	3	devised	devise	VBN
cord-001835-0s7ok4uw	3249	4	to	to	TO
cord-001835-0s7ok4uw	3249	5	insert	insert	VB
cord-001835-0s7ok4uw	3249	6	structurally	structurally	RB
cord-001835-0s7ok4uw	3249	7	defined	define	VBN
cord-001835-0s7ok4uw	3249	8	functional	functional	JJ
cord-001835-0s7ok4uw	3249	9	sites	site	NNS
cord-001835-0s7ok4uw	3249	10	into	into	IN
cord-001835-0s7ok4uw	3249	11	protein	protein	NN
cord-001835-0s7ok4uw	3249	12	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3249	13	.	.	.
cord-001835-0s7ok4uw	3250	1	Throughout	throughout	IN
cord-001835-0s7ok4uw	3250	2	the	the	DT
cord-001835-0s7ok4uw	3250	3	FFL	FFL	NNP
cord-001835-0s7ok4uw	3250	4	stages	stage	VBZ
cord-001835-0s7ok4uw	3250	5	the	the	DT
cord-001835-0s7ok4uw	3250	6	structure	structure	NN
cord-001835-0s7ok4uw	3250	7	of	of	IN
cord-001835-0s7ok4uw	3250	8	the	the	DT
cord-001835-0s7ok4uw	3250	9	scaffold	scaffold	NN
cord-001835-0s7ok4uw	3250	10	is	be	VBZ
cord-001835-0s7ok4uw	3250	11	folded	fold	VBN
cord-001835-0s7ok4uw	3250	12	and	and	CC
cord-001835-0s7ok4uw	3250	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3250	14	sequence	sequence	NN
cord-001835-0s7ok4uw	3250	15	designed	design	VBN
cord-001835-0s7ok4uw	3250	16	to	to	TO
cord-001835-0s7ok4uw	3250	17	stabilize	stabilize	VB
cord-001835-0s7ok4uw	3250	18	the	the	DT
cord-001835-0s7ok4uw	3250	19	desired	desire	VBN
cord-001835-0s7ok4uw	3250	20	functional	functional	JJ
cord-001835-0s7ok4uw	3250	21	conformation	conformation	NN
cord-001835-0s7ok4uw	3250	22	of	of	IN
cord-001835-0s7ok4uw	3250	23	the	the	DT
cord-001835-0s7ok4uw	3250	24	inserted	insert	VBN
cord-001835-0s7ok4uw	3250	25	site	site	NN
cord-001835-0s7ok4uw	3250	26	.	.	.
cord-001835-0s7ok4uw	3251	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3251	2	used	use	VBD
cord-001835-0s7ok4uw	3251	3	FFL	FFL	NNP
cord-001835-0s7ok4uw	3251	4	to	to	TO
cord-001835-0s7ok4uw	3251	5	design	design	VB
cord-001835-0s7ok4uw	3251	6	epitope	epitope	NN
cord-001835-0s7ok4uw	3251	7	-	-	HYPH
cord-001835-0s7ok4uw	3251	8	focused	focus	VBN
cord-001835-0s7ok4uw	3251	9	immunogens	immunogen	NNS
cord-001835-0s7ok4uw	3251	10	for	for	IN
cord-001835-0s7ok4uw	3251	11	the	the	DT
cord-001835-0s7ok4uw	3251	12	Respiratory	Respiratory	NNP
cord-001835-0s7ok4uw	3251	13	Syncytial	Syncytial	NNP
cord-001835-0s7ok4uw	3251	14	Virus	virus	NN
cord-001835-0s7ok4uw	3251	15	(	(	-LRB-
cord-001835-0s7ok4uw	3251	16	RSV	RSV	NNP
cord-001835-0s7ok4uw	3251	17	)	)	-RRB-
cord-001835-0s7ok4uw	3251	18	,	,	,
cord-001835-0s7ok4uw	3251	19	for	for	IN
cord-001835-0s7ok4uw	3251	20	which	which	WDT
cord-001835-0s7ok4uw	3251	21	despite	despite	IN
cord-001835-0s7ok4uw	3251	22	the	the	DT
cord-001835-0s7ok4uw	3251	23	intense	intense	JJ
cord-001835-0s7ok4uw	3251	24	research	research	NN
cord-001835-0s7ok4uw	3251	25	we	-PRON-	PRP
cord-001835-0s7ok4uw	3251	26	are	be	VBP
cord-001835-0s7ok4uw	3251	27	still	still	RB
cord-001835-0s7ok4uw	3251	28	lacking	lack	VBG
cord-001835-0s7ok4uw	3251	29	an	an	DT
cord-001835-0s7ok4uw	3251	30	approved	approve	VBN
cord-001835-0s7ok4uw	3251	31	vaccine	vaccine	NN
cord-001835-0s7ok4uw	3251	32	.	.	.
cord-001835-0s7ok4uw	3252	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3252	2	designed	design	VBD
cord-001835-0s7ok4uw	3252	3	three	three	CD
cord-001835-0s7ok4uw	3252	4	-	-	HYPH
cord-001835-0s7ok4uw	3252	5	helix	helix	NN
cord-001835-0s7ok4uw	3252	6	bundles	bundle	NNS
cord-001835-0s7ok4uw	3252	7	harboring	harbor	VBG
cord-001835-0s7ok4uw	3252	8	an	an	DT
cord-001835-0s7ok4uw	3252	9	RSV	RSV	NNP
cord-001835-0s7ok4uw	3252	10	epitope	epitope	NN
cord-001835-0s7ok4uw	3252	11	,	,	,
cord-001835-0s7ok4uw	3252	12	that	that	WDT
cord-001835-0s7ok4uw	3252	13	was	be	VBD
cord-001835-0s7ok4uw	3252	14	previously	previously	RB
cord-001835-0s7ok4uw	3252	15	co	co	VBN
cord-001835-0s7ok4uw	3252	16	-	-	VBN
cord-001835-0s7ok4uw	3252	17	crystallized	crystallize	VBN
cord-001835-0s7ok4uw	3252	18	with	with	IN
cord-001835-0s7ok4uw	3252	19	the	the	DT
cord-001835-0s7ok4uw	3252	20	neutralizing	neutralize	VBG
cord-001835-0s7ok4uw	3252	21	antibody	antibody	NN
cord-001835-0s7ok4uw	3252	22	motavizumab	motavizumab	NNP
cord-001835-0s7ok4uw	3252	23	.	.	.
cord-001835-0s7ok4uw	3253	1	The	the	DT
cord-001835-0s7ok4uw	3253	2	designs	design	NNS
cord-001835-0s7ok4uw	3253	3	were	be	VBD
cord-001835-0s7ok4uw	3253	4	thermodynamically	thermodynamically	RB
cord-001835-0s7ok4uw	3253	5	stable	stable	JJ
cord-001835-0s7ok4uw	3253	6	(	(	-LRB-
cord-001835-0s7ok4uw	3253	7	Tm	Tm	NNP
cord-001835-0s7ok4uw	3253	8	>	>	XX
cord-001835-0s7ok4uw	3253	9	100˚C	100˚c	CD
cord-001835-0s7ok4uw	3253	10	)	)	-RRB-
cord-001835-0s7ok4uw	3253	11	and	and	CC
cord-001835-0s7ok4uw	3253	12	showed	show	VBD
cord-001835-0s7ok4uw	3253	13	extremely	extremely	RB
cord-001835-0s7ok4uw	3253	14	high	high	JJ
cord-001835-0s7ok4uw	3253	15	affinities	affinity	NNS
cord-001835-0s7ok4uw	3253	16	to	to	IN
cord-001835-0s7ok4uw	3253	17	motavizumab	motavizumab	NNP
cord-001835-0s7ok4uw	3253	18	(	(	-LRB-
cord-001835-0s7ok4uw	3253	19	KD	KD	NNP
cord-001835-0s7ok4uw	3253	20	30	30	CD
cord-001835-0s7ok4uw	3253	21	pM	pM	NNP
cord-001835-0s7ok4uw	3253	22	)	)	-RRB-
cord-001835-0s7ok4uw	3253	23	.	.	.
cord-001835-0s7ok4uw	3254	1	Structural	structural	JJ
cord-001835-0s7ok4uw	3254	2	characterization	characterization	NN
cord-001835-0s7ok4uw	3254	3	through	through	IN
cord-001835-0s7ok4uw	3254	4	x	x	NN
cord-001835-0s7ok4uw	3254	5	-	-	NN
cord-001835-0s7ok4uw	3254	6	ray	ray	NN
cord-001835-0s7ok4uw	3254	7	crystallography	crystallography	NN
cord-001835-0s7ok4uw	3254	8	of	of	IN
cord-001835-0s7ok4uw	3254	9	antibodybound	antibodybound	JJ
cord-001835-0s7ok4uw	3254	10	and	and	CC
cord-001835-0s7ok4uw	3254	11	unbound	unbound	JJ
cord-001835-0s7ok4uw	3254	12	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3254	13	showed	show	VBD
cord-001835-0s7ok4uw	3254	14	good	good	JJ
cord-001835-0s7ok4uw	3254	15	agreement	agreement	NN
cord-001835-0s7ok4uw	3254	16	to	to	IN
cord-001835-0s7ok4uw	3254	17	the	the	DT
cord-001835-0s7ok4uw	3254	18	computational	computational	JJ
cord-001835-0s7ok4uw	3254	19	models	model	NNS
cord-001835-0s7ok4uw	3254	20	in	in	IN
cord-001835-0s7ok4uw	3254	21	the	the	DT
cord-001835-0s7ok4uw	3254	22	overall	overall	JJ
cord-001835-0s7ok4uw	3254	23	structure	structure	NN
cord-001835-0s7ok4uw	3254	24	(	(	-LRB-
cord-001835-0s7ok4uw	3254	25	rmsd	rmsd	JJ
cord-001835-0s7ok4uw	3254	26	-1.2	-1.2	NN
cord-001835-0s7ok4uw	3254	27	Å	Å	NNP
cord-001835-0s7ok4uw	3254	28	)	)	-RRB-
cord-001835-0s7ok4uw	3254	29	and	and	CC
cord-001835-0s7ok4uw	3254	30	exquisite	exquisite	JJ
cord-001835-0s7ok4uw	3254	31	mimicry	mimicry	NN
cord-001835-0s7ok4uw	3254	32	of	of	IN
cord-001835-0s7ok4uw	3254	33	the	the	DT
cord-001835-0s7ok4uw	3254	34	epitope	epitope	NN
cord-001835-0s7ok4uw	3254	35	region	region	NN
cord-001835-0s7ok4uw	3254	36	(	(	-LRB-
cord-001835-0s7ok4uw	3254	37	rmsd	rmsd	JJ
cord-001835-0s7ok4uw	3254	38	-0.4	-0.4	CD
cord-001835-0s7ok4uw	3254	39	Å	å	NN
cord-001835-0s7ok4uw	3254	40	)	)	-RRB-
cord-001835-0s7ok4uw	3254	41	,	,	,
cord-001835-0s7ok4uw	3254	42	when	when	WRB
cord-001835-0s7ok4uw	3254	43	compared	compare	VBN
cord-001835-0s7ok4uw	3254	44	to	to	IN
cord-001835-0s7ok4uw	3254	45	the	the	DT
cord-001835-0s7ok4uw	3254	46	peptide	peptide	NN
cord-001835-0s7ok4uw	3254	47	-	-	HYPH
cord-001835-0s7ok4uw	3254	48	epitope	epitope	NN
cord-001835-0s7ok4uw	3254	49	in	in	IN
cord-001835-0s7ok4uw	3254	50	complex	complex	NN
cord-001835-0s7ok4uw	3254	51	with	with	IN
cord-001835-0s7ok4uw	3254	52	motavizumab	motavizumab	NNS
cord-001835-0s7ok4uw	3254	53	.	.	.
cord-001835-0s7ok4uw	3255	1	The	the	DT
cord-001835-0s7ok4uw	3255	2	designed	design	VBN
cord-001835-0s7ok4uw	3255	3	immunogens	immunogen	NNS
cord-001835-0s7ok4uw	3255	4	were	be	VBD
cord-001835-0s7ok4uw	3255	5	used	use	VBN
cord-001835-0s7ok4uw	3255	6	to	to	TO
cord-001835-0s7ok4uw	3255	7	immunize	immunize	VB
cord-001835-0s7ok4uw	3255	8	non	non	JJ
cord-001835-0s7ok4uw	3255	9	-	-	JJ
cord-001835-0s7ok4uw	3255	10	human	human	JJ
cord-001835-0s7ok4uw	3255	11	primates	primate	NNS
cord-001835-0s7ok4uw	3255	12	(	(	-LRB-
cord-001835-0s7ok4uw	3255	13	NHP	NHP	NNP
cord-001835-0s7ok4uw	3255	14	)	)	-RRB-
cord-001835-0s7ok4uw	3255	15	,	,	,
cord-001835-0s7ok4uw	3255	16	and	and	CC
cord-001835-0s7ok4uw	3255	17	approximately	approximately	RB
cord-001835-0s7ok4uw	3255	18	75	75	CD
cord-001835-0s7ok4uw	3255	19	%	%	NN
cord-001835-0s7ok4uw	3255	20	of	of	IN
cord-001835-0s7ok4uw	3255	21	the	the	DT
cord-001835-0s7ok4uw	3255	22	cohort	cohort	NN
cord-001835-0s7ok4uw	3255	23	developed	develop	VBD
cord-001835-0s7ok4uw	3255	24	RSV	RSV	NNP
cord-001835-0s7ok4uw	3255	25	neutralizing	neutralize	VBG
cord-001835-0s7ok4uw	3255	26	activity	activity	NN
cord-001835-0s7ok4uw	3255	27	,	,	,
cord-001835-0s7ok4uw	3255	28	in	in	IN
cord-001835-0s7ok4uw	3255	29	some	some	DT
cord-001835-0s7ok4uw	3255	30	instances	instance	NNS
cord-001835-0s7ok4uw	3255	31	with	with	IN
cord-001835-0s7ok4uw	3255	32	high	high	JJ
cord-001835-0s7ok4uw	3255	33	potency	potency	NN
cord-001835-0s7ok4uw	3255	34	.	.	.
cord-001835-0s7ok4uw	3256	1	To	to	TO
cord-001835-0s7ok4uw	3256	2	evaluate	evaluate	VB
cord-001835-0s7ok4uw	3256	3	the	the	DT
cord-001835-0s7ok4uw	3256	4	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	3256	5	relevance	relevance	NN
cord-001835-0s7ok4uw	3256	6	of	of	IN
cord-001835-0s7ok4uw	3256	7	the	the	DT
cord-001835-0s7ok4uw	3256	8	elicited	elicit	VBN
cord-001835-0s7ok4uw	3256	9	neutralization	neutralization	NN
cord-001835-0s7ok4uw	3256	10	activity	activity	NN
cord-001835-0s7ok4uw	3256	11	,	,	,
cord-001835-0s7ok4uw	3256	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	3256	13	compared	compare	VBD
cord-001835-0s7ok4uw	3256	14	the	the	DT
cord-001835-0s7ok4uw	3256	15	NHP	NHP	NNP
cord-001835-0s7ok4uw	3256	16	neutralization	neutralization	NN
cord-001835-0s7ok4uw	3256	17	titers	titer	NNS
cord-001835-0s7ok4uw	3256	18	to	to	IN
cord-001835-0s7ok4uw	3256	19	those	those	DT
cord-001835-0s7ok4uw	3256	20	of	of	IN
cord-001835-0s7ok4uw	3256	21	human	human	JJ
cord-001835-0s7ok4uw	3256	22	sera	sera	NNP
cord-001835-0s7ok4uw	3256	23	after	after	IN
cord-001835-0s7ok4uw	3256	24	natural	natural	JJ
cord-001835-0s7ok4uw	3256	25	RSV	RSV	NNP
cord-001835-0s7ok4uw	3256	26	infection	infection	NN
cord-001835-0s7ok4uw	3256	27	,	,	,
cord-001835-0s7ok4uw	3256	28	which	which	WDT
cord-001835-0s7ok4uw	3256	29	generally	generally	RB
cord-001835-0s7ok4uw	3256	30	yields	yield	VBZ
cord-001835-0s7ok4uw	3256	31	protective	protective	JJ
cord-001835-0s7ok4uw	3256	32	levels	level	NNS
cord-001835-0s7ok4uw	3256	33	of	of	IN
cord-001835-0s7ok4uw	3256	34	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3256	35	.	.	.
cord-001835-0s7ok4uw	3257	1	The	the	DT
cord-001835-0s7ok4uw	3257	2	neutralization	neutralization	NN
cord-001835-0s7ok4uw	3257	3	potency	potency	NN
cord-001835-0s7ok4uw	3257	4	of	of	IN
cord-001835-0s7ok4uw	3257	5	the	the	DT
cord-001835-0s7ok4uw	3257	6	best	good	JJS
cord-001835-0s7ok4uw	3257	7	NHP	NHP	NNP
cord-001835-0s7ok4uw	3257	8	responders	responder	NNS
cord-001835-0s7ok4uw	3257	9	was	be	VBD
cord-001835-0s7ok4uw	3257	10	comparable	comparable	JJ
cord-001835-0s7ok4uw	3257	11	to	to	IN
cord-001835-0s7ok4uw	3257	12	that	that	DT
cord-001835-0s7ok4uw	3257	13	of	of	IN
cord-001835-0s7ok4uw	3257	14	the	the	DT
cord-001835-0s7ok4uw	3257	15	human	human	JJ
cord-001835-0s7ok4uw	3257	16	sera	sera	NNP
cord-001835-0s7ok4uw	3257	17	.	.	.
cord-001835-0s7ok4uw	3258	1	To	to	TO
cord-001835-0s7ok4uw	3258	2	better	better	RB
cord-001835-0s7ok4uw	3258	3	understand	understand	VB
cord-001835-0s7ok4uw	3258	4	the	the	DT
cord-001835-0s7ok4uw	3258	5	features	feature	NNS
cord-001835-0s7ok4uw	3258	6	of	of	IN
cord-001835-0s7ok4uw	3258	7	the	the	DT
cord-001835-0s7ok4uw	3258	8	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3258	9	elicited	elicit	VBN
cord-001835-0s7ok4uw	3258	10	,	,	,
cord-001835-0s7ok4uw	3258	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	3258	12	isolated	isolate	VBD
cord-001835-0s7ok4uw	3258	13	several	several	JJ
cord-001835-0s7ok4uw	3258	14	rhesus	rhesu	NNS
cord-001835-0s7ok4uw	3258	15	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	3258	16	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3258	17	(	(	-LRB-
cord-001835-0s7ok4uw	3258	18	RhmAbs	RhmAbs	NNP
cord-001835-0s7ok4uw	3258	19	)	)	-RRB-
cord-001835-0s7ok4uw	3258	20	from	from	IN
cord-001835-0s7ok4uw	3258	21	the	the	DT
cord-001835-0s7ok4uw	3258	22	animal	animal	NN
cord-001835-0s7ok4uw	3258	23	that	that	WDT
cord-001835-0s7ok4uw	3258	24	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	3258	25	the	the	DT
cord-001835-0s7ok4uw	3258	26	most	most	RBS
cord-001835-0s7ok4uw	3258	27	potent	potent	JJ
cord-001835-0s7ok4uw	3258	28	neutralization	neutralization	NN
cord-001835-0s7ok4uw	3258	29	.	.	.
cord-001835-0s7ok4uw	3259	1	Two	two	CD
cord-001835-0s7ok4uw	3259	2	of	of	IN
cord-001835-0s7ok4uw	3259	3	the	the	DT
cord-001835-0s7ok4uw	3259	4	RhmAbs	RhmAbs	NNP
cord-001835-0s7ok4uw	3259	5	bound	bind	VBN
cord-001835-0s7ok4uw	3259	6	to	to	IN
cord-001835-0s7ok4uw	3259	7	the	the	DT
cord-001835-0s7ok4uw	3259	8	immunogen	immunogen	NN
cord-001835-0s7ok4uw	3259	9	with	with	IN
cord-001835-0s7ok4uw	3259	10	very	very	RB
cord-001835-0s7ok4uw	3259	11	high	high	JJ
cord-001835-0s7ok4uw	3259	12	affinity	affinity	NN
cord-001835-0s7ok4uw	3259	13	(	(	-LRB-
cord-001835-0s7ok4uw	3259	14	KD	KD	NNP
cord-001835-0s7ok4uw	3259	15	3	3	CD
cord-001835-0s7ok4uw	3259	16	pM	pM	NNP
cord-001835-0s7ok4uw	3259	17	)	)	-RRB-
cord-001835-0s7ok4uw	3259	18	and	and	CC
cord-001835-0s7ok4uw	3259	19	were	be	VBD
cord-001835-0s7ok4uw	3259	20	potent	potent	JJ
cord-001835-0s7ok4uw	3259	21	RSV	RSV	NNP
cord-001835-0s7ok4uw	3259	22	neutralizers	neutralizer	NNS
cord-001835-0s7ok4uw	3259	23	.	.	.
cord-001835-0s7ok4uw	3260	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	3260	2	,	,	,
cord-001835-0s7ok4uw	3260	3	these	these	DT
cord-001835-0s7ok4uw	3260	4	RhmAbs	RhmAbs	NNP
cord-001835-0s7ok4uw	3260	5	were	be	VBD
cord-001835-0s7ok4uw	3260	6	approximately	approximately	RB
cord-001835-0s7ok4uw	3260	7	10	10	CD
cord-001835-0s7ok4uw	3260	8	fold	fold	VB
cord-001835-0s7ok4uw	3260	9	more	more	RBR
cord-001835-0s7ok4uw	3260	10	potent	potent	JJ
cord-001835-0s7ok4uw	3260	11	than	than	IN
cord-001835-0s7ok4uw	3260	12	the	the	DT
cord-001835-0s7ok4uw	3260	13	FDA	FDA	NNP
cord-001835-0s7ok4uw	3260	14	-	-	HYPH
cord-001835-0s7ok4uw	3260	15	approved	approve	VBN
cord-001835-0s7ok4uw	3260	16	prophylactic	prophylactic	JJ
cord-001835-0s7ok4uw	3260	17	antibody	antibody	NN
cord-001835-0s7ok4uw	3260	18	Palivizumab	Palivizumab	NNP
cord-001835-0s7ok4uw	3260	19	.	.	.
cord-001835-0s7ok4uw	3261	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3261	2	results	result	NNS
cord-001835-0s7ok4uw	3261	3	provide	provide	VBP
cord-001835-0s7ok4uw	3261	4	the	the	DT
cord-001835-0s7ok4uw	3261	5	first	first	JJ
cord-001835-0s7ok4uw	3261	6	proof	proof	NN
cord-001835-0s7ok4uw	3261	7	-	-	HYPH
cord-001835-0s7ok4uw	3261	8	of	of	IN
cord-001835-0s7ok4uw	3261	9	-	-	HYPH
cord-001835-0s7ok4uw	3261	10	principle	principle	NN
cord-001835-0s7ok4uw	3261	11	for	for	IN
cord-001835-0s7ok4uw	3261	12	epitope	epitope	NN
cord-001835-0s7ok4uw	3261	13	-	-	HYPH
cord-001835-0s7ok4uw	3261	14	focused	focus	VBN
cord-001835-0s7ok4uw	3261	15	vaccine	vaccine	NN
cord-001835-0s7ok4uw	3261	16	design	design	NN
cord-001835-0s7ok4uw	3261	17	,	,	,
cord-001835-0s7ok4uw	3261	18	and	and	CC
cord-001835-0s7ok4uw	3261	19	demonstrate	demonstrate	VB
cord-001835-0s7ok4uw	3261	20	the	the	DT
cord-001835-0s7ok4uw	3261	21	power	power	NN
cord-001835-0s7ok4uw	3261	22	of	of	IN
cord-001835-0s7ok4uw	3261	23	the	the	DT
cord-001835-0s7ok4uw	3261	24	FFL	FFL	NNP
cord-001835-0s7ok4uw	3261	25	Figure	Figure	NNP
cord-001835-0s7ok4uw	3261	26	1	1	CD
cord-001835-0s7ok4uw	3261	27	.	.	.
cord-001835-0s7ok4uw	3262	1	Schematic	Schematic	NNP
cord-001835-0s7ok4uw	3262	2	of	of	IN
cord-001835-0s7ok4uw	3262	3	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	3262	4	binding	binding	NN
cord-001835-0s7ok4uw	3262	5	,	,	,
cord-001835-0s7ok4uw	3262	6	exchange	exchange	NN
cord-001835-0s7ok4uw	3262	7	and	and	CC
cord-001835-0s7ok4uw	3262	8	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	3262	9	in	in	IN
cord-001835-0s7ok4uw	3262	10	tubulin	tubulin	NN
cord-001835-0s7ok4uw	3262	11	,	,	,
cord-001835-0s7ok4uw	3262	12	and	and	CC
cord-001835-0s7ok4uw	3262	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3262	14	coupling	coupling	NN
cord-001835-0s7ok4uw	3262	15	to	to	IN
cord-001835-0s7ok4uw	3262	16	MT	MT	NNP
cord-001835-0s7ok4uw	3262	17	assembly	assembly	NN
cord-001835-0s7ok4uw	3262	18	.	.	.
cord-001835-0s7ok4uw	3263	1	Exchange	Exchange	NNP
cord-001835-0s7ok4uw	3263	2	of	of	IN
cord-001835-0s7ok4uw	3263	3	GDP	GDP	NNP
cord-001835-0s7ok4uw	3263	4	(	(	-LRB-
cord-001835-0s7ok4uw	3263	5	orange	orange	NNP
cord-001835-0s7ok4uw	3263	6	)	)	-RRB-
cord-001835-0s7ok4uw	3263	7	for	for	IN
cord-001835-0s7ok4uw	3263	8	GTP	GTP	NNP
cord-001835-0s7ok4uw	3263	9	(	(	-LRB-
cord-001835-0s7ok4uw	3263	10	magenta	magenta	NN
cord-001835-0s7ok4uw	3263	11	)	)	-RRB-
cord-001835-0s7ok4uw	3263	12	at	at	IN
cord-001835-0s7ok4uw	3263	13	the	the	DT
cord-001835-0s7ok4uw	3263	14	E	e	NN
cord-001835-0s7ok4uw	3263	15	-	-	NN
cord-001835-0s7ok4uw	3263	16	site	site	NN
cord-001835-0s7ok4uw	3263	17	in	in	IN
cord-001835-0s7ok4uw	3263	18	b	b	NN
cord-001835-0s7ok4uw	3263	19	-	-	HYPH
cord-001835-0s7ok4uw	3263	20	tubulin	tubulin	JJ
cord-001835-0s7ok4uw	3263	21	(	(	-LRB-
cord-001835-0s7ok4uw	3263	22	blue	blue	NNP
cord-001835-0s7ok4uw	3263	23	)	)	-RRB-
cord-001835-0s7ok4uw	3263	24	happens	happen	VBZ
cord-001835-0s7ok4uw	3263	25	in	in	IN
cord-001835-0s7ok4uw	3263	26	the	the	DT
cord-001835-0s7ok4uw	3263	27	unpolymerized	unpolymerized	JJ
cord-001835-0s7ok4uw	3263	28	dimer	dimer	NNP
cord-001835-0s7ok4uw	3263	29	(	(	-LRB-
cord-001835-0s7ok4uw	3263	30	left	left	RB
cord-001835-0s7ok4uw	3263	31	)	)	-RRB-
cord-001835-0s7ok4uw	3263	32	.	.	.
cord-001835-0s7ok4uw	3264	1	The	the	DT
cord-001835-0s7ok4uw	3264	2	active	active	JJ
cord-001835-0s7ok4uw	3264	3	,	,	,
cord-001835-0s7ok4uw	3264	4	GTPbound	gtpbound	NN
cord-001835-0s7ok4uw	3264	5	tubulin	tubulin	NN
cord-001835-0s7ok4uw	3264	6	dimer	dimer	NN
cord-001835-0s7ok4uw	3264	7	adds	add	VBZ
cord-001835-0s7ok4uw	3264	8	to	to	IN
cord-001835-0s7ok4uw	3264	9	a	a	DT
cord-001835-0s7ok4uw	3264	10	growing	grow	VBG
cord-001835-0s7ok4uw	3264	11	MT	MT	NNP
cord-001835-0s7ok4uw	3264	12	(	(	-LRB-
cord-001835-0s7ok4uw	3264	13	right	right	RB
cord-001835-0s7ok4uw	3264	14	)	)	-RRB-
cord-001835-0s7ok4uw	3264	15	.	.	.
cord-001835-0s7ok4uw	3265	1	Interaction	interaction	NN
cord-001835-0s7ok4uw	3265	2	of	of	IN
cord-001835-0s7ok4uw	3265	3	the	the	DT
cord-001835-0s7ok4uw	3265	4	incoming	incoming	JJ
cord-001835-0s7ok4uw	3265	5	a	a	DT
cord-001835-0s7ok4uw	3265	6	-	-	HYPH
cord-001835-0s7ok4uw	3265	7	tubulin	tubulin	JJ
cord-001835-0s7ok4uw	3265	8	(	(	-LRB-
cord-001835-0s7ok4uw	3265	9	green	green	JJ
cord-001835-0s7ok4uw	3265	10	)	)	-RRB-
cord-001835-0s7ok4uw	3265	11	with	with	IN
cord-001835-0s7ok4uw	3265	12	the	the	DT
cord-001835-0s7ok4uw	3265	13	E	e	NN
cord-001835-0s7ok4uw	3265	14	-	-	NN
cord-001835-0s7ok4uw	3265	15	site	site	NN
cord-001835-0s7ok4uw	3265	16	nucleotide	nucleotide	NN
cord-001835-0s7ok4uw	3265	17	at	at	IN
cord-001835-0s7ok4uw	3265	18	the	the	DT
cord-001835-0s7ok4uw	3265	19	plus	plus	JJ
cord-001835-0s7ok4uw	3265	20	end	end	NN
cord-001835-0s7ok4uw	3265	21	of	of	IN
cord-001835-0s7ok4uw	3265	22	a	a	DT
cord-001835-0s7ok4uw	3265	23	MT	MT	NNP
cord-001835-0s7ok4uw	3265	24	(	(	-LRB-
cord-001835-0s7ok4uw	3265	25	with	with	IN
cord-001835-0s7ok4uw	3265	26	b	b	NN
cord-001835-0s7ok4uw	3265	27	-	-	HYPH
cord-001835-0s7ok4uw	3265	28	tubulin	tubulin	NN
cord-001835-0s7ok4uw	3265	29	exposed	expose	VBN
cord-001835-0s7ok4uw	3265	30	)	)	-RRB-
cord-001835-0s7ok4uw	3265	31	results	result	NNS
cord-001835-0s7ok4uw	3265	32	in	in	IN
cord-001835-0s7ok4uw	3265	33	GTP	gtp	NN
cord-001835-0s7ok4uw	3265	34	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	3265	35	.	.	.
cord-001835-0s7ok4uw	3266	1	The	the	DT
cord-001835-0s7ok4uw	3266	2	MT	MT	NNP
cord-001835-0s7ok4uw	3266	3	cartoon	cartoon	NN
cord-001835-0s7ok4uw	3266	4	(	(	-LRB-
cord-001835-0s7ok4uw	3266	5	bottom	bottom	NN
cord-001835-0s7ok4uw	3266	6	right	right	RB
cord-001835-0s7ok4uw	3266	7	)	)	-RRB-
cord-001835-0s7ok4uw	3266	8	shows	show	VBZ
cord-001835-0s7ok4uw	3266	9	an	an	DT
cord-001835-0s7ok4uw	3266	10	oversimplified	oversimplified	JJ
cord-001835-0s7ok4uw	3266	11	representation	representation	NN
cord-001835-0s7ok4uw	3266	12	of	of	IN
cord-001835-0s7ok4uw	3266	13	a	a	DT
cord-001835-0s7ok4uw	3266	14	GTP	GTP	NNP
cord-001835-0s7ok4uw	3266	15	cap	cap	NN
cord-001835-0s7ok4uw	3266	16	as	as	IN
cord-001835-0s7ok4uw	3266	17	it	-PRON-	PRP
cord-001835-0s7ok4uw	3266	18	first	first	RB
cord-001835-0s7ok4uw	3266	19	grows	grow	VBZ
cord-001835-0s7ok4uw	3266	20	by	by	IN
cord-001835-0s7ok4uw	3266	21	tubulin	tubulin	NN
cord-001835-0s7ok4uw	3266	22	addition	addition	NN
cord-001835-0s7ok4uw	3266	23	and	and	CC
cord-001835-0s7ok4uw	3266	24	then	then	RB
cord-001835-0s7ok4uw	3266	25	shrinks	shrink	VBZ
cord-001835-0s7ok4uw	3266	26	by	by	IN
cord-001835-0s7ok4uw	3266	27	polymerization	polymerization	NN
cord-001835-0s7ok4uw	3266	28	-	-	HYPH
cord-001835-0s7ok4uw	3266	29	coupled	couple	VBN
cord-001835-0s7ok4uw	3266	30	GTP	gtp	NN
cord-001835-0s7ok4uw	3266	31	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	3266	32	(	(	-LRB-
cord-001835-0s7ok4uw	3266	33	here	here	RB
cord-001835-0s7ok4uw	3266	34	b	b	NN
cord-001835-0s7ok4uw	3266	35	-	-	HYPH
cord-001835-0s7ok4uw	3266	36	tubulin	tubulin	NN
cord-001835-0s7ok4uw	3266	37	that	that	WDT
cord-001835-0s7ok4uw	3266	38	is	be	VBZ
cord-001835-0s7ok4uw	3266	39	bound	bind	VBN
cord-001835-0s7ok4uw	3266	40	to	to	IN
cord-001835-0s7ok4uw	3266	41	GTP	GTP	NNP
cord-001835-0s7ok4uw	3266	42	is	be	VBZ
cord-001835-0s7ok4uw	3266	43	shown	show	VBN
cord-001835-0s7ok4uw	3266	44	in	in	IN
cord-001835-0s7ok4uw	3266	45	red	red	NN
cord-001835-0s7ok4uw	3266	46	and	and	CC
cord-001835-0s7ok4uw	3266	47	that	that	DT
cord-001835-0s7ok4uw	3266	48	bound	bind	VBN
cord-001835-0s7ok4uw	3266	49	to	to	IN
cord-001835-0s7ok4uw	3266	50	GDP	GDP	NNP
cord-001835-0s7ok4uw	3266	51	is	be	VBZ
cord-001835-0s7ok4uw	3266	52	shown	show	VBN
cord-001835-0s7ok4uw	3266	53	in	in	IN
cord-001835-0s7ok4uw	3266	54	blue	blue	JJ
cord-001835-0s7ok4uw	3266	55	)	)	-RRB-
cord-001835-0s7ok4uw	3266	56	.	.	.
cord-001835-0s7ok4uw	3267	1	Cryo	cryo	NN
cord-001835-0s7ok4uw	3267	2	-	-	HYPH
cord-001835-0s7ok4uw	3267	3	EM	em	NN
cord-001835-0s7ok4uw	3267	4	density	density	NN
cord-001835-0s7ok4uw	3267	5	map	map	NN
cord-001835-0s7ok4uw	3267	6	(	(	-LRB-
cord-001835-0s7ok4uw	3267	7	EMDB-6349	EMDB-6349	NNP
cord-001835-0s7ok4uw	3267	8	)	)	-RRB-
cord-001835-0s7ok4uw	3267	9	and	and	CC
cord-001835-0s7ok4uw	3267	10	atomic	atomic	JJ
cord-001835-0s7ok4uw	3267	11	model	model	NN
cord-001835-0s7ok4uw	3267	12	(	(	-LRB-
cord-001835-0s7ok4uw	3267	13	PDB	PDB	NNP
cord-001835-0s7ok4uw	3267	14	:	:	:
cord-001835-0s7ok4uw	3267	15	3JAK	3JAK	NNP
cord-001835-0s7ok4uw	3267	16	)	)	-RRB-
cord-001835-0s7ok4uw	3268	1	for	for	IN
cord-001835-0s7ok4uw	3268	2	an	an	DT
cord-001835-0s7ok4uw	3268	3	EB3-decorated	eb3-decorate	VBN
cord-001835-0s7ok4uw	3268	4	MT	MT	NNP
cord-001835-0s7ok4uw	3268	5	bound	bind	VBN
cord-001835-0s7ok4uw	3268	6	to	to	IN
cord-001835-0s7ok4uw	3268	7	GTPgS.	GTPgS.	NNP
cord-001835-0s7ok4uw	3268	8	a	a	DT
cord-001835-0s7ok4uw	3268	9	-	-	HYPH
cord-001835-0s7ok4uw	3268	10	tubulin	tubulin	NN
cord-001835-0s7ok4uw	3268	11	,	,	,
cord-001835-0s7ok4uw	3268	12	b	b	NN
cord-001835-0s7ok4uw	3268	13	-	-	HYPH
cord-001835-0s7ok4uw	3268	14	tubulin	tubulin	NN
cord-001835-0s7ok4uw	3268	15	and	and	CC
cord-001835-0s7ok4uw	3268	16	EB3	EB3	NNS
cord-001835-0s7ok4uw	3268	17	are	be	VBP
cord-001835-0s7ok4uw	3268	18	colored	color	VBN
cord-001835-0s7ok4uw	3268	19	green	green	JJ
cord-001835-0s7ok4uw	3268	20	,	,	,
cord-001835-0s7ok4uw	3268	21	blue	blue	JJ
cord-001835-0s7ok4uw	3268	22	,	,	,
cord-001835-0s7ok4uw	3268	23	and	and	CC
cord-001835-0s7ok4uw	3268	24	orange	orange	NN
cord-001835-0s7ok4uw	3268	25	,	,	,
cord-001835-0s7ok4uw	3268	26	respectively	respectively	RB
cord-001835-0s7ok4uw	3268	27	.	.	.
cord-001835-0s7ok4uw	3269	1	computational	computational	JJ
cord-001835-0s7ok4uw	3269	2	methodology	methodology	NN
cord-001835-0s7ok4uw	3269	3	.	.	.
cord-001835-0s7ok4uw	3270	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3270	2	anticipate	anticipate	VBP
cord-001835-0s7ok4uw	3270	3	that	that	IN
cord-001835-0s7ok4uw	3270	4	FFL	FFL	NNP
cord-001835-0s7ok4uw	3270	5	will	will	MD
cord-001835-0s7ok4uw	3270	6	be	be	VB
cord-001835-0s7ok4uw	3270	7	useful	useful	JJ
cord-001835-0s7ok4uw	3270	8	for	for	IN
cord-001835-0s7ok4uw	3270	9	a	a	DT
cord-001835-0s7ok4uw	3270	10	variety	variety	NN
cord-001835-0s7ok4uw	3270	11	of	of	IN
cord-001835-0s7ok4uw	3270	12	other	other	JJ
cord-001835-0s7ok4uw	3270	13	challenges	challenge	NNS
cord-001835-0s7ok4uw	3270	14	in	in	IN
cord-001835-0s7ok4uw	3270	15	the	the	DT
cord-001835-0s7ok4uw	3270	16	computational	computational	JJ
cord-001835-0s7ok4uw	3270	17	design	design	NN
cord-001835-0s7ok4uw	3270	18	of	of	IN
cord-001835-0s7ok4uw	3270	19	functional	functional	JJ
cord-001835-0s7ok4uw	3270	20	proteins	protein	NNS
cord-001835-0s7ok4uw	3270	21	.	.	.
cord-001835-0s7ok4uw	3271	1	Designed	design	VBN
cord-001835-0s7ok4uw	3271	2	repeat	repeat	NN
cord-001835-0s7ok4uw	3271	3	proteins	protein	NNS
cord-001835-0s7ok4uw	3271	4	as	as	IN
cord-001835-0s7ok4uw	3271	5	templates	template	NNS
cord-001835-0s7ok4uw	3271	6	for	for	IN
cord-001835-0s7ok4uw	3271	7	photoactive	photoactive	JJ
cord-001835-0s7ok4uw	3271	8	molecules	molecule	NNS
cord-001835-0s7ok4uw	3271	9	and	and	CC
cord-001835-0s7ok4uw	3271	10	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	3271	11	nanoclusters	nanocluster	NNS
cord-001835-0s7ok4uw	3271	12	Sara	Sara	NNP
cord-001835-0s7ok4uw	3271	13	H.	H.	NNP
cord-001835-0s7ok4uw	3271	14	Mejias	Mejias	NNP
cord-001835-0s7ok4uw	3271	15	1,2	1,2	CD
cord-001835-0s7ok4uw	3271	16	,	,	,
cord-001835-0s7ok4uw	3271	17	Antonio	Antonio	NNP
cord-001835-0s7ok4uw	3271	18	Aires	Aires	NNP
cord-001835-0s7ok4uw	3271	19	1,2	1,2	CD
cord-001835-0s7ok4uw	3271	20	,	,	,
cord-001835-0s7ok4uw	3271	21	Javier	Javier	NNP
cord-001835-0s7ok4uw	3271	22	L	L	NNP
cord-001835-0s7ok4uw	3271	23	opez	opez	NNP
cord-001835-0s7ok4uw	3271	24	-	-	HYPH
cord-001835-0s7ok4uw	3271	25	Andarias	Andarias	NNP
cord-001835-0s7ok4uw	3271	26	3	3	CD
cord-001835-0s7ok4uw	3271	27	,	,	,
cord-001835-0s7ok4uw	3271	28	Pierre	Pierre	NNP
cord-001835-0s7ok4uw	3271	29	Couleaud	Couleaud	NNP
cord-001835-0s7ok4uw	3271	30	1,2	1,2	CD
cord-001835-0s7ok4uw	3271	31	,	,	,
cord-001835-0s7ok4uw	3271	32	Begoña	Begoña	NNP
cord-001835-0s7ok4uw	3271	33	Sot	Sot	NNP
cord-001835-0s7ok4uw	3271	34	1,2	1,2	CD
cord-001835-0s7ok4uw	3271	35	,	,	,
cord-001835-0s7ok4uw	3271	36	Carmen	Carmen	NNP
cord-001835-0s7ok4uw	3271	37	Atienza	Atienza	NNP
cord-001835-0s7ok4uw	3271	38	3	3	CD
cord-001835-0s7ok4uw	3271	39	,	,	,
cord-001835-0s7ok4uw	3271	40	Nazario	Nazario	NNP
cord-001835-0s7ok4uw	3271	41	Mart	Mart	NNP
cord-001835-0s7ok4uw	3272	1	ın	ın	IN
cord-001835-0s7ok4uw	3272	2	1,3	1,3	CD
cord-001835-0s7ok4uw	3272	3	,	,	,
cord-001835-0s7ok4uw	3272	4	Aitziber	Aitziber	NNP
cord-001835-0s7ok4uw	3272	5	L.	L.	NNP
cord-001835-0s7ok4uw	3272	6	Cortajarena	Cortajarena	NNP
cord-001835-0s7ok4uw	3273	1	1,2	1,2	CD
cord-001835-0s7ok4uw	3273	2	1	1	CD
cord-001835-0s7ok4uw	3274	1	IMDEA	IMDEA	NNP
cord-001835-0s7ok4uw	3274	2	Nanoscience	Nanoscience	NNP
cord-001835-0s7ok4uw	3274	3	,	,	,
cord-001835-0s7ok4uw	3274	4	c	c	NN
cord-001835-0s7ok4uw	3274	5	/	/	SYM
cord-001835-0s7ok4uw	3274	6	Faraday	Faraday	NNP
cord-001835-0s7ok4uw	3274	7	,	,	,
cord-001835-0s7ok4uw	3274	8	9	9	CD
cord-001835-0s7ok4uw	3274	9	,	,	,
cord-001835-0s7ok4uw	3274	10	Ciudad	Ciudad	NNP
cord-001835-0s7ok4uw	3274	11	Universitaria	Universitaria	NNP
cord-001835-0s7ok4uw	3274	12	de	de	NNP
cord-001835-0s7ok4uw	3274	13	Cantoblanco	Cantoblanco	NNP
cord-001835-0s7ok4uw	3274	14	28049	28049	CD
cord-001835-0s7ok4uw	3274	15	,	,	,
cord-001835-0s7ok4uw	3274	16	2	2	CD
cord-001835-0s7ok4uw	3274	17	CNB	CNB	NNP
cord-001835-0s7ok4uw	3274	18	-	-	HYPH
cord-001835-0s7ok4uw	3274	19	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	3274	20	-	-	HYPH
cord-001835-0s7ok4uw	3274	21	IMDEA	IMDEA	NNP
cord-001835-0s7ok4uw	3274	22	Nanociencia	Nanociencia	NNP
cord-001835-0s7ok4uw	3274	23	Associated	Associated	NNP
cord-001835-0s7ok4uw	3274	24	Unit	Unit	NNP
cord-001835-0s7ok4uw	3274	25	"	"	``
cord-001835-0s7ok4uw	3274	26	Unidad	Unidad	NNP
cord-001835-0s7ok4uw	3274	27	de	de	NNP
cord-001835-0s7ok4uw	3274	28	Nanobiotecnolog	Nanobiotecnolog	NNP
cord-001835-0s7ok4uw	3274	29	ıa	ıa	NNPS
cord-001835-0s7ok4uw	3274	30	"	"	''
cord-001835-0s7ok4uw	3274	31	,	,	,
cord-001835-0s7ok4uw	3274	32	3	3	CD
cord-001835-0s7ok4uw	3274	33	Departamento	Departamento	NNP
cord-001835-0s7ok4uw	3274	34	de	de	NNP
cord-001835-0s7ok4uw	3274	35	Qu	Qu	NNP
cord-001835-0s7ok4uw	3274	36	ımica	ımica	NNP
cord-001835-0s7ok4uw	3275	1	Org	Org	NNP
cord-001835-0s7ok4uw	3275	2	anica	anica	NNP
cord-001835-0s7ok4uw	3276	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	3276	2	,	,	,
cord-001835-0s7ok4uw	3276	3	Facultad	Facultad	NNP
cord-001835-0s7ok4uw	3276	4	de	de	NNP
cord-001835-0s7ok4uw	3276	5	Qu	Qu	NNP
cord-001835-0s7ok4uw	3276	6	ımica	ımica	NNP
cord-001835-0s7ok4uw	3276	7	,	,	,
cord-001835-0s7ok4uw	3276	8	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	3276	9	Complutense	Complutense	NNP
cord-001835-0s7ok4uw	3276	10	Self	Self	NNP
cord-001835-0s7ok4uw	3276	11	-	-	HYPH
cord-001835-0s7ok4uw	3276	12	assembly	assembly	NN
cord-001835-0s7ok4uw	3276	13	of	of	IN
cord-001835-0s7ok4uw	3276	14	biological	biological	JJ
cord-001835-0s7ok4uw	3276	15	molecules	molecule	NNS
cord-001835-0s7ok4uw	3276	16	into	into	IN
cord-001835-0s7ok4uw	3276	17	defined	define	VBN
cord-001835-0s7ok4uw	3276	18	functional	functional	JJ
cord-001835-0s7ok4uw	3276	19	structures	structure	NNS
cord-001835-0s7ok4uw	3276	20	has	have	VBZ
cord-001835-0s7ok4uw	3276	21	a	a	DT
cord-001835-0s7ok4uw	3276	22	tremendous	tremendous	JJ
cord-001835-0s7ok4uw	3276	23	potential	potential	NN
cord-001835-0s7ok4uw	3276	24	in	in	IN
cord-001835-0s7ok4uw	3276	25	nanopatterning	nanopatterning	NN
cord-001835-0s7ok4uw	3276	26	,	,	,
cord-001835-0s7ok4uw	3276	27	and	and	CC
cord-001835-0s7ok4uw	3276	28	the	the	DT
cord-001835-0s7ok4uw	3276	29	design	design	NN
cord-001835-0s7ok4uw	3276	30	of	of	IN
cord-001835-0s7ok4uw	3276	31	novel	novel	JJ
cord-001835-0s7ok4uw	3276	32	bionanomaterials	bionanomaterial	NNS
cord-001835-0s7ok4uw	3276	33	and	and	CC
cord-001835-0s7ok4uw	3276	34	functional	functional	JJ
cord-001835-0s7ok4uw	3276	35	devices	device	NNS
cord-001835-0s7ok4uw	3276	36	.	.	.
cord-001835-0s7ok4uw	3277	1	Molecular	molecular	JJ
cord-001835-0s7ok4uw	3277	2	selfassembly	selfassembly	RB
cord-001835-0s7ok4uw	3277	3	is	be	VBZ
cord-001835-0s7ok4uw	3277	4	a	a	DT
cord-001835-0s7ok4uw	3277	5	process	process	NN
cord-001835-0s7ok4uw	3277	6	by	by	IN
cord-001835-0s7ok4uw	3277	7	which	which	WDT
cord-001835-0s7ok4uw	3277	8	complex	complex	JJ
cord-001835-0s7ok4uw	3277	9	three	three	CD
cord-001835-0s7ok4uw	3277	10	-	-	HYPH
cord-001835-0s7ok4uw	3277	11	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	3277	12	structures	structure	NNS
cord-001835-0s7ok4uw	3277	13	with	with	IN
cord-001835-0s7ok4uw	3277	14	specified	specify	VBN
cord-001835-0s7ok4uw	3277	15	functions	function	NNS
cord-001835-0s7ok4uw	3277	16	are	be	VBP
cord-001835-0s7ok4uw	3277	17	constructed	construct	VBN
cord-001835-0s7ok4uw	3277	18	from	from	IN
cord-001835-0s7ok4uw	3277	19	simple	simple	JJ
cord-001835-0s7ok4uw	3277	20	molecular	molecular	JJ
cord-001835-0s7ok4uw	3277	21	building	building	NN
cord-001835-0s7ok4uw	3277	22	blocks	block	NNS
cord-001835-0s7ok4uw	3277	23	.	.	.
cord-001835-0s7ok4uw	3278	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3278	2	present	present	VBP
cord-001835-0s7ok4uw	3278	3	first	first	RB
cord-001835-0s7ok4uw	3278	4	the	the	DT
cord-001835-0s7ok4uw	3278	5	study	study	NN
cord-001835-0s7ok4uw	3278	6	and	and	CC
cord-001835-0s7ok4uw	3278	7	characterization	characterization	NN
cord-001835-0s7ok4uw	3278	8	of	of	IN
cord-001835-0s7ok4uw	3278	9	the	the	DT
cord-001835-0s7ok4uw	3278	10	assembly	assembly	NN
cord-001835-0s7ok4uw	3278	11	properties	property	NNS
cord-001835-0s7ok4uw	3278	12	of	of	IN
cord-001835-0s7ok4uw	3278	13	modular	modular	JJ
cord-001835-0s7ok4uw	3278	14	repeat	repeat	NN
cord-001835-0s7ok4uw	3278	15	proteins	protein	NNS
cord-001835-0s7ok4uw	3278	16	,	,	,
cord-001835-0s7ok4uw	3278	17	in	in	IN
cord-001835-0s7ok4uw	3278	18	particular	particular	JJ
cord-001835-0s7ok4uw	3278	19	designed	design	VBN
cord-001835-0s7ok4uw	3278	20	consensus	consensus	NN
cord-001835-0s7ok4uw	3278	21	tetratricopeptide	tetratricopeptide	NN
cord-001835-0s7ok4uw	3278	22	repeats	repeat	VBZ
cord-001835-0s7ok4uw	3278	23	(	(	-LRB-
cord-001835-0s7ok4uw	3278	24	CTPRs	CTPRs	NNP
cord-001835-0s7ok4uw	3278	25	)	)	-RRB-
cord-001835-0s7ok4uw	3278	26	,	,	,
cord-001835-0s7ok4uw	3278	27	and	and	CC
cord-001835-0s7ok4uw	3278	28	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3278	29	application	application	NN
cord-001835-0s7ok4uw	3278	30	as	as	IN
cord-001835-0s7ok4uw	3278	31	building	building	NN
cord-001835-0s7ok4uw	3278	32	blocks	block	NNS
cord-001835-0s7ok4uw	3278	33	in	in	IN
cord-001835-0s7ok4uw	3278	34	order	order	NN
cord-001835-0s7ok4uw	3278	35	to	to	TO
cord-001835-0s7ok4uw	3278	36	generate	generate	VB
cord-001835-0s7ok4uw	3278	37	functional	functional	JJ
cord-001835-0s7ok4uw	3278	38	nanostructures	nanostructure	NNS
cord-001835-0s7ok4uw	3278	39	and	and	CC
cord-001835-0s7ok4uw	3278	40	biomaterials	biomaterial	NNS
cord-001835-0s7ok4uw	3278	41	.	.	.
cord-001835-0s7ok4uw	3279	1	CTPR	CTPR	NNP
cord-001835-0s7ok4uw	3279	2	proteins	protein	NNS
cord-001835-0s7ok4uw	3279	3	can	can	MD
cord-001835-0s7ok4uw	3279	4	be	be	VB
cord-001835-0s7ok4uw	3279	5	assembled	assemble	VBN
cord-001835-0s7ok4uw	3279	6	into	into	IN
cord-001835-0s7ok4uw	3279	7	self	self	NN
cord-001835-0s7ok4uw	3279	8	-	-	HYPH
cord-001835-0s7ok4uw	3279	9	standing	stand	VBG
cord-001835-0s7ok4uw	3279	10	thin	thin	RB
cord-001835-0s7ok4uw	3279	11	films,1	films,1	IN
cord-001835-0s7ok4uw	3279	12	and	and	CC
cord-001835-0s7ok4uw	3279	13	thin	thin	JJ
cord-001835-0s7ok4uw	3279	14	nanometer	nanometer	NN
cord-001835-0s7ok4uw	3279	15	fibers	fiber	NNS
cord-001835-0s7ok4uw	3279	16	in	in	IN
cord-001835-0s7ok4uw	3279	17	solution.2	solution.2	NNP
cord-001835-0s7ok4uw	3280	1	In	in	IN
cord-001835-0s7ok4uw	3280	2	this	this	DT
cord-001835-0s7ok4uw	3280	3	work	work	NN
cord-001835-0s7ok4uw	3280	4	,	,	,
cord-001835-0s7ok4uw	3280	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3280	6	show	show	VBP
cord-001835-0s7ok4uw	3280	7	the	the	DT
cord-001835-0s7ok4uw	3280	8	use	use	NN
cord-001835-0s7ok4uw	3280	9	of	of	IN
cord-001835-0s7ok4uw	3280	10	the	the	DT
cord-001835-0s7ok4uw	3280	11	designed	design	VBN
cord-001835-0s7ok4uw	3280	12	consensus	consensus	NN
cord-001835-0s7ok4uw	3280	13	repeat	repeat	NN
cord-001835-0s7ok4uw	3280	14	proteins	protein	NNS
cord-001835-0s7ok4uw	3280	15	as	as	IN
cord-001835-0s7ok4uw	3280	16	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3280	17	to	to	IN
cord-001835-0s7ok4uw	3280	18	template	template	NN
cord-001835-0s7ok4uw	3280	19	:	:	:
cord-001835-0s7ok4uw	3280	20	(	(	-LRB-
cord-001835-0s7ok4uw	3280	21	1	1	LS
cord-001835-0s7ok4uw	3280	22	)	)	-RRB-
cord-001835-0s7ok4uw	3280	23	photoactive	photoactive	JJ
cord-001835-0s7ok4uw	3280	24	organic	organic	JJ
cord-001835-0s7ok4uw	3280	25	molecules	molecule	NNS
cord-001835-0s7ok4uw	3280	26	,	,	,
cord-001835-0s7ok4uw	3280	27	and	and	CC
cord-001835-0s7ok4uw	3280	28	(	(	-LRB-
cord-001835-0s7ok4uw	3280	29	2	2	LS
cord-001835-0s7ok4uw	3280	30	)	)	-RRB-
cord-001835-0s7ok4uw	3280	31	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	3280	32	nanoclusters	nanocluster	NNS
cord-001835-0s7ok4uw	3280	33	.	.	.
cord-001835-0s7ok4uw	3281	1	1.We	1.we	CD
cord-001835-0s7ok4uw	3281	2	explore	explore	VB
cord-001835-0s7ok4uw	3281	3	the	the	DT
cord-001835-0s7ok4uw	3281	4	potential	potential	NN
cord-001835-0s7ok4uw	3281	5	of	of	IN
cord-001835-0s7ok4uw	3281	6	CTPR	CTPR	NNP
cord-001835-0s7ok4uw	3281	7	proteins	protein	NNS
cord-001835-0s7ok4uw	3281	8	to	to	TO
cord-001835-0s7ok4uw	3281	9	arrange	arrange	VB
cord-001835-0s7ok4uw	3281	10	donor	donor	NN
cord-001835-0s7ok4uw	3281	11	-	-	HYPH
cord-001835-0s7ok4uw	3281	12	acceptor	acceptor	NN
cord-001835-0s7ok4uw	3281	13	pairs	pair	NNS
cord-001835-0s7ok4uw	3281	14	for	for	IN
cord-001835-0s7ok4uw	3281	15	electro	electro	JJ
cord-001835-0s7ok4uw	3281	16	-	-	HYPH
cord-001835-0s7ok4uw	3281	17	active	active	JJ
cord-001835-0s7ok4uw	3281	18	materials	material	NNS
cord-001835-0s7ok4uw	3281	19	.	.	.
cord-001835-0s7ok4uw	3282	1	In	in	IN
cord-001835-0s7ok4uw	3282	2	particular	particular	JJ
cord-001835-0s7ok4uw	3282	3	,	,	,
cord-001835-0s7ok4uw	3282	4	porphyrin	porphyrin	NN
cord-001835-0s7ok4uw	3282	5	rings	ring	NNS
cord-001835-0s7ok4uw	3282	6	arranged	arrange	VBN
cord-001835-0s7ok4uw	3282	7	by	by	IN
cord-001835-0s7ok4uw	3282	8	CTPRs	CTPRs	NNP
cord-001835-0s7ok4uw	3282	9	in	in	IN
cord-001835-0s7ok4uw	3282	10	a	a	DT
cord-001835-0s7ok4uw	3282	11	defined	define	VBN
cord-001835-0s7ok4uw	3282	12	distance	distance	NN
cord-001835-0s7ok4uw	3282	13	and	and	CC
cord-001835-0s7ok4uw	3282	14	orientation	orientation	NN
cord-001835-0s7ok4uw	3282	15	for	for	IN
cord-001835-0s7ok4uw	3282	16	favoring	favor	VBG
cord-001835-0s7ok4uw	3282	17	face	face	NN
cord-001835-0s7ok4uw	3282	18	-	-	HYPH
cord-001835-0s7ok4uw	3282	19	to	to	IN
cord-001835-0s7ok4uw	3282	20	-	-	HYPH
cord-001835-0s7ok4uw	3282	21	face	face	NN
cord-001835-0s7ok4uw	3282	22	orientation	orientation	NN
cord-001835-0s7ok4uw	3282	23	which	which	WDT
cord-001835-0s7ok4uw	3282	24	should	should	MD
cord-001835-0s7ok4uw	3282	25	lead	lead	VB
cord-001835-0s7ok4uw	3282	26	to	to	IN
cord-001835-0s7ok4uw	3282	27	an	an	DT
cord-001835-0s7ok4uw	3282	28	improvement	improvement	NN
cord-001835-0s7ok4uw	3282	29	in	in	IN
cord-001835-0s7ok4uw	3282	30	the	the	DT
cord-001835-0s7ok4uw	3282	31	optoelectronic	optoelectronic	JJ
cord-001835-0s7ok4uw	3282	32	properties	property	NNS
cord-001835-0s7ok4uw	3282	33	.	.	.
cord-001835-0s7ok4uw	3283	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3283	2	results	result	NNS
cord-001835-0s7ok4uw	3283	3	confirm	confirm	VBP
cord-001835-0s7ok4uw	3283	4	the	the	DT
cord-001835-0s7ok4uw	3283	5	successful	successful	JJ
cord-001835-0s7ok4uw	3283	6	ability	ability	NN
cord-001835-0s7ok4uw	3283	7	of	of	IN
cord-001835-0s7ok4uw	3283	8	CTPR	CTPR	NNP
cord-001835-0s7ok4uw	3283	9	proteins	protein	NNS
cord-001835-0s7ok4uw	3283	10	to	to	TO
cord-001835-0s7ok4uw	3283	11	be	be	VB
cord-001835-0s7ok4uw	3283	12	used	use	VBN
cord-001835-0s7ok4uw	3283	13	as	as	IN
cord-001835-0s7ok4uw	3283	14	scaffold	scaffold	NN
cord-001835-0s7ok4uw	3283	15	for	for	IN
cord-001835-0s7ok4uw	3283	16	ordering	order	VBG
cord-001835-0s7ok4uw	3283	17	organic	organic	JJ
cord-001835-0s7ok4uw	3283	18	chromophores	chromophore	NNS
cord-001835-0s7ok4uw	3283	19	,	,	,
cord-001835-0s7ok4uw	3283	20	while	while	IN
cord-001835-0s7ok4uw	3283	21	preserving	preserve	VBG
cord-001835-0s7ok4uw	3283	22	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3283	23	structure	structure	NN
cord-001835-0s7ok4uw	3283	24	.	.	.
cord-001835-0s7ok4uw	3284	1	The	the	DT
cord-001835-0s7ok4uw	3284	2	unique	unique	JJ
cord-001835-0s7ok4uw	3284	3	self	self	NN
cord-001835-0s7ok4uw	3284	4	assembly	assembly	NN
cord-001835-0s7ok4uw	3284	5	properties	property	NNS
cord-001835-0s7ok4uw	3284	6	of	of	IN
cord-001835-0s7ok4uw	3284	7	CTPR	CTPR	NNP
cord-001835-0s7ok4uw	3284	8	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3284	9	have	have	VBP
cord-001835-0s7ok4uw	3284	10	been	be	VBN
cord-001835-0s7ok4uw	3284	11	exploited	exploit	VBN
cord-001835-0s7ok4uw	3284	12	to	to	TO
cord-001835-0s7ok4uw	3284	13	generate	generate	VB
cord-001835-0s7ok4uw	3284	14	ordered	order	VBN
cord-001835-0s7ok4uw	3284	15	conductive	conductive	JJ
cord-001835-0s7ok4uw	3284	16	films	film	NNS
cord-001835-0s7ok4uw	3284	17	of	of	IN
cord-001835-0s7ok4uw	3284	18	the	the	DT
cord-001835-0s7ok4uw	3284	19	protein	protein	NN
cord-001835-0s7ok4uw	3284	20	-	-	HYPH
cord-001835-0s7ok4uw	3284	21	porphyrin	porphyrin	NN
cord-001835-0s7ok4uw	3284	22	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	3284	23	.	.	.
cord-001835-0s7ok4uw	3285	1	These	these	DT
cord-001835-0s7ok4uw	3285	2	results	result	NNS
cord-001835-0s7ok4uw	3285	3	open	open	VBP
cord-001835-0s7ok4uw	3285	4	the	the	DT
cord-001835-0s7ok4uw	3285	5	door	door	NN
cord-001835-0s7ok4uw	3285	6	to	to	TO
cord-001835-0s7ok4uw	3285	7	fabricate	fabricate	VB
cord-001835-0s7ok4uw	3285	8	hybrid	hybrid	JJ
cord-001835-0s7ok4uw	3285	9	protein	protein	NN
cord-001835-0s7ok4uw	3285	10	-	-	HYPH
cord-001835-0s7ok4uw	3285	11	based	base	VBN
cord-001835-0s7ok4uw	3285	12	solid	solid	JJ
cord-001835-0s7ok4uw	3285	13	devices	device	NNS
cord-001835-0s7ok4uw	3285	14	.	.	.
cord-001835-0s7ok4uw	3286	1	2.We	2.we	CD
cord-001835-0s7ok4uw	3286	2	show	show	VBP
cord-001835-0s7ok4uw	3286	3	results	result	NNS
cord-001835-0s7ok4uw	3286	4	on	on	IN
cord-001835-0s7ok4uw	3286	5	the	the	DT
cord-001835-0s7ok4uw	3286	6	ability	ability	NN
cord-001835-0s7ok4uw	3286	7	of	of	IN
cord-001835-0s7ok4uw	3286	8	CTPR	CTPR	NNP
cord-001835-0s7ok4uw	3286	9	to	to	TO
cord-001835-0s7ok4uw	3286	10	encapsulate	encapsulate	VB
cord-001835-0s7ok4uw	3286	11	and	and	CC
cord-001835-0s7ok4uw	3286	12	stabilize	stabilize	VB
cord-001835-0s7ok4uw	3286	13	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	3286	14	gold	gold	NN
cord-001835-0s7ok4uw	3286	15	nanoclusters	nanocluster	NNS
cord-001835-0s7ok4uw	3286	16	.	.	.
cord-001835-0s7ok4uw	3287	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3287	2	investigated	investigate	VBD
cord-001835-0s7ok4uw	3287	3	the	the	DT
cord-001835-0s7ok4uw	3287	4	influence	influence	NN
cord-001835-0s7ok4uw	3287	5	of	of	IN
cord-001835-0s7ok4uw	3287	6	the	the	DT
cord-001835-0s7ok4uw	3287	7	protein	protein	NN
cord-001835-0s7ok4uw	3287	8	sequence	sequence	NN
cord-001835-0s7ok4uw	3287	9	in	in	IN
cord-001835-0s7ok4uw	3287	10	the	the	DT
cord-001835-0s7ok4uw	3287	11	final	final	JJ
cord-001835-0s7ok4uw	3287	12	properties	property	NNS
cord-001835-0s7ok4uw	3287	13	of	of	IN
cord-001835-0s7ok4uw	3287	14	the	the	DT
cord-001835-0s7ok4uw	3287	15	nanoclusters	nanocluster	NNS
cord-001835-0s7ok4uw	3287	16	.	.	.
cord-001835-0s7ok4uw	3288	1	The	the	DT
cord-001835-0s7ok4uw	3288	2	structural	structural	JJ
cord-001835-0s7ok4uw	3288	3	and	and	CC
cord-001835-0s7ok4uw	3288	4	functional	functional	JJ
cord-001835-0s7ok4uw	3288	5	integrity	integrity	NN
cord-001835-0s7ok4uw	3288	6	of	of	IN
cord-001835-0s7ok4uw	3288	7	the	the	DT
cord-001835-0s7ok4uw	3288	8	protein	protein	NN
cord-001835-0s7ok4uw	3288	9	template	template	NN
cord-001835-0s7ok4uw	3288	10	is	be	VBZ
cord-001835-0s7ok4uw	3288	11	critical	critical	JJ
cord-001835-0s7ok4uw	3288	12	for	for	IN
cord-001835-0s7ok4uw	3288	13	future	future	JJ
cord-001835-0s7ok4uw	3288	14	applications	application	NNS
cord-001835-0s7ok4uw	3288	15	of	of	IN
cord-001835-0s7ok4uw	3288	16	the	the	DT
cord-001835-0s7ok4uw	3288	17	protein	protein	NN
cord-001835-0s7ok4uw	3288	18	-	-	HYPH
cord-001835-0s7ok4uw	3288	19	cluster	cluster	NN
cord-001835-0s7ok4uw	3288	20	complexes	complex	NNS
cord-001835-0s7ok4uw	3288	21	.	.	.
cord-001835-0s7ok4uw	3289	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	3289	2	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3289	3	protocols	protocol	NNS
cord-001835-0s7ok4uw	3289	4	that	that	WDT
cord-001835-0s7ok4uw	3289	5	retain	retain	VBP
cord-001835-0s7ok4uw	3289	6	the	the	DT
cord-001835-0s7ok4uw	3289	7	protein	protein	NN
cord-001835-0s7ok4uw	3289	8	structure	structure	NN
cord-001835-0s7ok4uw	3289	9	and	and	CC
cord-001835-0s7ok4uw	3289	10	function	function	NN
cord-001835-0s7ok4uw	3289	11	have	have	VBP
cord-001835-0s7ok4uw	3289	12	been	be	VBN
cord-001835-0s7ok4uw	3289	13	developed	develop	VBN
cord-001835-0s7ok4uw	3289	14	.	.	.
cord-001835-0s7ok4uw	3290	1	As	as	IN
cord-001835-0s7ok4uw	3290	2	a	a	DT
cord-001835-0s7ok4uw	3290	3	proof	proof	NN
cord-001835-0s7ok4uw	3290	4	of	of	IN
cord-001835-0s7ok4uw	3290	5	concept	concept	NN
cord-001835-0s7ok4uw	3290	6	,	,	,
cord-001835-0s7ok4uw	3290	7	a	a	DT
cord-001835-0s7ok4uw	3290	8	CTPR	CTPR	NNP
cord-001835-0s7ok4uw	3290	9	module	module	NN
cord-001835-0s7ok4uw	3290	10	with	with	IN
cord-001835-0s7ok4uw	3290	11	specific	specific	JJ
cord-001835-0s7ok4uw	3290	12	binding	bind	VBG
cord-001835-0s7ok4uw	3290	13	capabilities	capability	NNS
cord-001835-0s7ok4uw	3290	14	has	have	VBZ
cord-001835-0s7ok4uw	3290	15	been	be	VBN
cord-001835-0s7ok4uw	3290	16	successfully	successfully	RB
cord-001835-0s7ok4uw	3290	17	used	use	VBN
cord-001835-0s7ok4uw	3290	18	to	to	TO
cord-001835-0s7ok4uw	3290	19	stabilize	stabilize	VB
cord-001835-0s7ok4uw	3290	20	nano	nano	NN
cord-001835-0s7ok4uw	3290	21	clusters	cluster	NNS
cord-001835-0s7ok4uw	3290	22	.	.	.
cord-001835-0s7ok4uw	3291	1	Biohybrid	Biohybrid	NNP
cord-001835-0s7ok4uw	3291	2	photoelectrochemical	photoelectrochemical	JJ
cord-001835-0s7ok4uw	3291	3	cells	cell	NNS
cord-001835-0s7ok4uw	3291	4	have	have	VBP
cord-001835-0s7ok4uw	3291	5	been	be	VBN
cord-001835-0s7ok4uw	3291	6	developed	develop	VBN
cord-001835-0s7ok4uw	3291	7	by	by	IN
cord-001835-0s7ok4uw	3291	8	functionalizing	functionalize	VBG
cord-001835-0s7ok4uw	3291	9	the	the	DT
cord-001835-0s7ok4uw	3291	10	hematite	hematite	NNP
cord-001835-0s7ok4uw	3291	11	photoanode	photoanode	NNP
cord-001835-0s7ok4uw	3291	12	with	with	IN
cord-001835-0s7ok4uw	3291	13	the	the	DT
cord-001835-0s7ok4uw	3291	14	light	light	NN
cord-001835-0s7ok4uw	3291	15	-	-	HYPH
cord-001835-0s7ok4uw	3291	16	harvesting	harvest	VBG
cord-001835-0s7ok4uw	3291	17	cyanobacterial	cyanobacterial	JJ
cord-001835-0s7ok4uw	3291	18	protein	protein	NN
cord-001835-0s7ok4uw	3291	19	C	C	NNP
cord-001835-0s7ok4uw	3291	20	-	-	HYPH
cord-001835-0s7ok4uw	3291	21	phycocyanin	phycocyanin	NNP
cord-001835-0s7ok4uw	3291	22	(	(	-LRB-
cord-001835-0s7ok4uw	3291	23	PC	pc	NN
cord-001835-0s7ok4uw	3291	24	)	)	-RRB-
cord-001835-0s7ok4uw	3291	25	yielding	yield	VBG
cord-001835-0s7ok4uw	3291	26	a	a	DT
cord-001835-0s7ok4uw	3291	27	substantial	substantial	JJ
cord-001835-0s7ok4uw	3291	28	enhancement	enhancement	NN
cord-001835-0s7ok4uw	3291	29	of	of	IN
cord-001835-0s7ok4uw	3291	30	the	the	DT
cord-001835-0s7ok4uw	3291	31	photocurrent	photocurrent	NN
cord-001835-0s7ok4uw	3291	32	density	density	NN
cord-001835-0s7ok4uw	3291	33	.	.	.
cord-001835-0s7ok4uw	3292	1	Photoelectrochemical	photoelectrochemical	JJ
cord-001835-0s7ok4uw	3292	2	cells	cell	NNS
cord-001835-0s7ok4uw	3292	3	combining	combine	VBG
cord-001835-0s7ok4uw	3292	4	light	light	NN
cord-001835-0s7ok4uw	3292	5	-	-	HYPH
cord-001835-0s7ok4uw	3292	6	harvesting	harvest	VBG
cord-001835-0s7ok4uw	3292	7	proteins	protein	NNS
cord-001835-0s7ok4uw	3292	8	and	and	CC
cord-001835-0s7ok4uw	3292	9	inorganic	inorganic	JJ
cord-001835-0s7ok4uw	3292	10	semiconductors	semiconductor	NNS
cord-001835-0s7ok4uw	3292	11	have	have	VBP
cord-001835-0s7ok4uw	3292	12	potential	potential	NN
cord-001835-0s7ok4uw	3292	13	for	for	IN
cord-001835-0s7ok4uw	3292	14	the	the	DT
cord-001835-0s7ok4uw	3292	15	use	use	NN
cord-001835-0s7ok4uw	3292	16	in	in	IN
cord-001835-0s7ok4uw	3292	17	artificial	artificial	JJ
cord-001835-0s7ok4uw	3292	18	photosynthesis	photosynthesis	NN
cord-001835-0s7ok4uw	3292	19	.	.	.
cord-001835-0s7ok4uw	3293	1	In	in	IN
cord-001835-0s7ok4uw	3293	2	this	this	DT
cord-001835-0s7ok4uw	3293	3	work	work	NN
cord-001835-0s7ok4uw	3293	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3293	5	present	present	VBP
cord-001835-0s7ok4uw	3293	6	processing	processing	NN
cord-001835-0s7ok4uw	3293	7	routes	route	NNS
cord-001835-0s7ok4uw	3293	8	for	for	IN
cord-001835-0s7ok4uw	3293	9	the	the	DT
cord-001835-0s7ok4uw	3293	10	functionalization	functionalization	NN
cord-001835-0s7ok4uw	3293	11	of	of	IN
cord-001835-0s7ok4uw	3293	12	hematite	hematite	JJ
cord-001835-0s7ok4uw	3293	13	photoanodes	photoanode	NNS
cord-001835-0s7ok4uw	3293	14	with	with	IN
cord-001835-0s7ok4uw	3293	15	PC	pc	NN
cord-001835-0s7ok4uw	3293	16	,	,	,
cord-001835-0s7ok4uw	3293	17	including	include	VBG
cord-001835-0s7ok4uw	3293	18	in	in	IN
cord-001835-0s7ok4uw	3293	19	situ	situ	JJ
cord-001835-0s7ok4uw	3293	20	co	co	NN
cord-001835-0s7ok4uw	3293	21	-	-	NN
cord-001835-0s7ok4uw	3293	22	polymerization	polymerization	NN
cord-001835-0s7ok4uw	3293	23	of	of	IN
cord-001835-0s7ok4uw	3293	24	PC	pc	NN
cord-001835-0s7ok4uw	3293	25	with	with	IN
cord-001835-0s7ok4uw	3293	26	enzymatically	enzymatically	RB
cord-001835-0s7ok4uw	3293	27	-	-	HYPH
cord-001835-0s7ok4uw	3293	28	produced	produce	VBN
cord-001835-0s7ok4uw	3293	29	melanin	melanin	NN
cord-001835-0s7ok4uw	3293	30	and	and	CC
cord-001835-0s7ok4uw	3293	31	using	use	VBG
cord-001835-0s7ok4uw	3293	32	a	a	DT
cord-001835-0s7ok4uw	3293	33	recombinantly	recombinantly	RB
cord-001835-0s7ok4uw	3293	34	produced	produce	VBN
cord-001835-0s7ok4uw	3293	35	PC	pc	NN
cord-001835-0s7ok4uw	3293	36	2	2	CD
cord-001835-0s7ok4uw	3293	37	.	.	.
cord-001835-0s7ok4uw	3294	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	3294	2	,	,	,
cord-001835-0s7ok4uw	3294	3	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	3294	4	forms	form	NNS
cord-001835-0s7ok4uw	3294	5	of	of	IN
cord-001835-0s7ok4uw	3294	6	the	the	DT
cord-001835-0s7ok4uw	3294	7	light	light	NN
cord-001835-0s7ok4uw	3294	8	-	-	HYPH
cord-001835-0s7ok4uw	3294	9	harvesting	harvest	VBG
cord-001835-0s7ok4uw	3294	10	protein	protein	NN
cord-001835-0s7ok4uw	3294	11	C	c	NN
cord-001835-0s7ok4uw	3294	12	-	-	HYPH
cord-001835-0s7ok4uw	3294	13	phycocyanin	phycocyanin	NNP
cord-001835-0s7ok4uw	3294	14	from	from	IN
cord-001835-0s7ok4uw	3294	15	Synechocystis	Synechocystis	NNP
cord-001835-0s7ok4uw	3294	16	sp	sp	NN
cord-001835-0s7ok4uw	3294	17	.	.	.
cord-001835-0s7ok4uw	3295	1	PCC6803	PCC6803	NNP
cord-001835-0s7ok4uw	3295	2	were	be	VBD
cord-001835-0s7ok4uw	3295	3	engineered	engineer	VBN
cord-001835-0s7ok4uw	3295	4	to	to	TO
cord-001835-0s7ok4uw	3295	5	carry	carry	VB
cord-001835-0s7ok4uw	3295	6	a	a	DT
cord-001835-0s7ok4uw	3295	7	peptide	peptide	NN
cord-001835-0s7ok4uw	3295	8	with	with	IN
cord-001835-0s7ok4uw	3295	9	affinity	affinity	NN
cord-001835-0s7ok4uw	3295	10	for	for	IN
cord-001835-0s7ok4uw	3295	11	hematite	hematite	NN
cord-001835-0s7ok4uw	3295	12	.	.	.
cord-001835-0s7ok4uw	3296	1	Similarly	similarly	RB
cord-001835-0s7ok4uw	3296	2	,	,	,
cord-001835-0s7ok4uw	3296	3	a	a	DT
cord-001835-0s7ok4uw	3296	4	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	3296	5	laccase	laccase	NN
cord-001835-0s7ok4uw	3296	6	was	be	VBD
cord-001835-0s7ok4uw	3296	7	engineered	engineer	VBN
cord-001835-0s7ok4uw	3296	8	to	to	TO
cord-001835-0s7ok4uw	3296	9	acquire	acquire	VB
cord-001835-0s7ok4uw	3296	10	affinity	affinity	NN
cord-001835-0s7ok4uw	3296	11	for	for	IN
cord-001835-0s7ok4uw	3296	12	hematite	hematite	NN
cord-001835-0s7ok4uw	3296	13	.	.	.
cord-001835-0s7ok4uw	3297	1	Results	result	NNS
cord-001835-0s7ok4uw	3297	2	obtained	obtain	VBN
cord-001835-0s7ok4uw	3297	3	from	from	IN
cord-001835-0s7ok4uw	3297	4	the	the	DT
cord-001835-0s7ok4uw	3297	5	different	different	JJ
cord-001835-0s7ok4uw	3297	6	approaches	approach	NNS
cord-001835-0s7ok4uw	3297	7	to	to	IN
cord-001835-0s7ok4uw	3297	8	hematite	hematite	JJ
cord-001835-0s7ok4uw	3297	9	functionalization	functionalization	NN
cord-001835-0s7ok4uw	3297	10	and	and	CC
cord-001835-0s7ok4uw	3297	11	the	the	DT
cord-001835-0s7ok4uw	3297	12	advantages	advantage	NNS
cord-001835-0s7ok4uw	3297	13	offered	offer	VBN
cord-001835-0s7ok4uw	3297	14	by	by	IN
cord-001835-0s7ok4uw	3297	15	protein	protein	NN
cord-001835-0s7ok4uw	3297	16	engineering	engineering	NN
cord-001835-0s7ok4uw	3297	17	will	will	MD
cord-001835-0s7ok4uw	3297	18	be	be	VB
cord-001835-0s7ok4uw	3297	19	presented	present	VBN
cord-001835-0s7ok4uw	3297	20	.	.	.
cord-001835-0s7ok4uw	3298	1	Minimizing	minimize	VBG
cord-001835-0s7ok4uw	3298	2	a	a	DT
cord-001835-0s7ok4uw	3298	3	suitable	suitable	JJ
cord-001835-0s7ok4uw	3298	4	free	free	JJ
cord-001835-0s7ok4uw	3298	5	energy	energy	NN
cord-001835-0s7ok4uw	3298	6	expression	expression	NN
cord-001835-0s7ok4uw	3298	7	is	be	VBZ
cord-001835-0s7ok4uw	3298	8	arguably	arguably	RB
cord-001835-0s7ok4uw	3298	9	the	the	DT
cord-001835-0s7ok4uw	3298	10	most	most	RBS
cord-001835-0s7ok4uw	3298	11	common	common	JJ
cord-001835-0s7ok4uw	3298	12	approach	approach	NN
cord-001835-0s7ok4uw	3298	13	in	in	IN
cord-001835-0s7ok4uw	3298	14	(	(	-LRB-
cord-001835-0s7ok4uw	3298	15	ab	ab	FW
cord-001835-0s7ok4uw	3298	16	initio	initio	NNP
cord-001835-0s7ok4uw	3298	17	)	)	-RRB-
cord-001835-0s7ok4uw	3298	18	protein	protein	NN
cord-001835-0s7ok4uw	3298	19	structure	structure	NN
cord-001835-0s7ok4uw	3298	20	prediction	prediction	NN
cord-001835-0s7ok4uw	3298	21	.	.	.
cord-001835-0s7ok4uw	3299	1	The	the	DT
cord-001835-0s7ok4uw	3299	2	achieved	achieve	VBN
cord-001835-0s7ok4uw	3299	3	accuracy	accuracy	NN
cord-001835-0s7ok4uw	3299	4	depends	depend	VBZ
cord-001835-0s7ok4uw	3299	5	crucially	crucially	RB
cord-001835-0s7ok4uw	3299	6	on	on	IN
cord-001835-0s7ok4uw	3299	7	the	the	DT
cord-001835-0s7ok4uw	3299	8	quality	quality	NN
cord-001835-0s7ok4uw	3299	9	of	of	IN
cord-001835-0s7ok4uw	3299	10	the	the	DT
cord-001835-0s7ok4uw	3299	11	free	free	JJ
cord-001835-0s7ok4uw	3299	12	energy	energy	NN
cord-001835-0s7ok4uw	3299	13	expression	expression	NN
cord-001835-0s7ok4uw	3299	14	in	in	IN
cord-001835-0s7ok4uw	3299	15	use	use	NN
cord-001835-0s7ok4uw	3299	16	.	.	.
cord-001835-0s7ok4uw	3300	1	Here	here	RB
cord-001835-0s7ok4uw	3300	2	,	,	,
cord-001835-0s7ok4uw	3300	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3300	4	present	present	VBP
cord-001835-0s7ok4uw	3300	5	corrections	correction	NNS
cord-001835-0s7ok4uw	3300	6	to	to	IN
cord-001835-0s7ok4uw	3300	7	existing	exist	VBG
cord-001835-0s7ok4uw	3300	8	free	free	JJ
cord-001835-0s7ok4uw	3300	9	energy	energy	NN
cord-001835-0s7ok4uw	3300	10	expressions	expression	NNS
cord-001835-0s7ok4uw	3300	11	which	which	WDT
cord-001835-0s7ok4uw	3300	12	arise	arise	VBP
cord-001835-0s7ok4uw	3300	13	from	from	IN
cord-001835-0s7ok4uw	3300	14	the	the	DT
cord-001835-0s7ok4uw	3300	15	thermal	thermal	JJ
cord-001835-0s7ok4uw	3300	16	motion	motion	NN
cord-001835-0s7ok4uw	3300	17	of	of	IN
cord-001835-0s7ok4uw	3300	18	the	the	DT
cord-001835-0s7ok4uw	3300	19	protein	protein	NN
cord-001835-0s7ok4uw	3300	20	.	.	.
cord-001835-0s7ok4uw	3301	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3301	2	(	(	-LRB-
cord-001835-0s7ok4uw	3301	3	i	i	NN
cord-001835-0s7ok4uw	3301	4	)	)	-RRB-
cord-001835-0s7ok4uw	3301	5	devise	devise	VB
cord-001835-0s7ok4uw	3301	6	a	a	DT
cord-001835-0s7ok4uw	3301	7	term	term	NN
cord-001835-0s7ok4uw	3301	8	accounting	account	VBG
cord-001835-0s7ok4uw	3301	9	for	for	IN
cord-001835-0s7ok4uw	3301	10	the	the	DT
cord-001835-0s7ok4uw	3301	11	vibrational	vibrational	JJ
cord-001835-0s7ok4uw	3301	12	entropy	entropy	NN
cord-001835-0s7ok4uw	3301	13	of	of	IN
cord-001835-0s7ok4uw	3301	14	the	the	DT
cord-001835-0s7ok4uw	3301	15	protein	protein	NN
cord-001835-0s7ok4uw	3301	16	,	,	,
cord-001835-0s7ok4uw	3301	17	and	and	CC
cord-001835-0s7ok4uw	3301	18	(	(	-LRB-
cord-001835-0s7ok4uw	3301	19	ii	ii	NN
cord-001835-0s7ok4uw	3301	20	)	)	-RRB-
cord-001835-0s7ok4uw	3301	21	correct	correct	JJ
cord-001835-0s7ok4uw	3301	22	existing	exist	VBG
cord-001835-0s7ok4uw	3301	23	potentials	potential	NNS
cord-001835-0s7ok4uw	3301	24	for	for	IN
cord-001835-0s7ok4uw	3301	25	'	'	``
cord-001835-0s7ok4uw	3301	26	thermal	thermal	JJ
cord-001835-0s7ok4uw	3301	27	smoothing	smoothing	NN
cord-001835-0s7ok4uw	3301	28	'	'	''
cord-001835-0s7ok4uw	3301	29	.	.	.
cord-001835-0s7ok4uw	3302	1	(	(	-LRB-
cord-001835-0s7ok4uw	3302	2	i	i	NN
cord-001835-0s7ok4uw	3302	3	)	)	-RRB-
cord-001835-0s7ok4uw	3303	1	Vibrational	vibrational	JJ
cord-001835-0s7ok4uw	3303	2	entropy	entropy	NN
cord-001835-0s7ok4uw	3303	3	is	be	VBZ
cord-001835-0s7ok4uw	3303	4	almost	almost	RB
cord-001835-0s7ok4uw	3303	5	always	always	RB
cord-001835-0s7ok4uw	3303	6	neglected	neglect	VBN
cord-001835-0s7ok4uw	3303	7	in	in	IN
cord-001835-0s7ok4uw	3303	8	free	free	JJ
cord-001835-0s7ok4uw	3303	9	energy	energy	NN
cord-001835-0s7ok4uw	3303	10	expressions	expression	NNS
cord-001835-0s7ok4uw	3303	11	as	as	IN
cord-001835-0s7ok4uw	3303	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3303	13	consideration	consideration	NN
cord-001835-0s7ok4uw	3303	14	is	be	VBZ
cord-001835-0s7ok4uw	3303	15	difficult	difficult	JJ
cord-001835-0s7ok4uw	3303	16	.	.	.
cord-001835-0s7ok4uw	3304	1	This	this	DT
cord-001835-0s7ok4uw	3304	2	practice	practice	NN
cord-001835-0s7ok4uw	3304	3	,	,	,
cord-001835-0s7ok4uw	3304	4	however	however	RB
cord-001835-0s7ok4uw	3304	5	,	,	,
cord-001835-0s7ok4uw	3304	6	may	may	MD
cord-001835-0s7ok4uw	3304	7	lead	lead	VB
cord-001835-0s7ok4uw	3304	8	to	to	IN
cord-001835-0s7ok4uw	3304	9	incorrect	incorrect	JJ
cord-001835-0s7ok4uw	3304	10	output	output	NN
cord-001835-0s7ok4uw	3304	11	because	because	IN
cord-001835-0s7ok4uw	3304	12	distinct	distinct	JJ
cord-001835-0s7ok4uw	3304	13	conformations	conformation	NNS
cord-001835-0s7ok4uw	3304	14	of	of	IN
cord-001835-0s7ok4uw	3304	15	a	a	DT
cord-001835-0s7ok4uw	3304	16	protein	protein	NN
cord-001835-0s7ok4uw	3304	17	can	can	MD
cord-001835-0s7ok4uw	3304	18	contain	contain	VB
cord-001835-0s7ok4uw	3304	19	very	very	RB
cord-001835-0s7ok4uw	3304	20	different	different	JJ
cord-001835-0s7ok4uw	3304	21	amount	amount	NN
cord-001835-0s7ok4uw	3304	22	of	of	IN
cord-001835-0s7ok4uw	3304	23	vibrational	vibrational	JJ
cord-001835-0s7ok4uw	3304	24	entropy	entropy	NN
cord-001835-0s7ok4uw	3304	25	,	,	,
cord-001835-0s7ok4uw	3304	26	as	as	IN
cord-001835-0s7ok4uw	3304	27	we	-PRON-	PRP
cord-001835-0s7ok4uw	3304	28	show	show	VBP
cord-001835-0s7ok4uw	3304	29	for	for	IN
cord-001835-0s7ok4uw	3304	30	the	the	DT
cord-001835-0s7ok4uw	3304	31	chicken	chicken	NN
cord-001835-0s7ok4uw	3304	32	villin	villin	NNP
cord-001835-0s7ok4uw	3304	33	headpiece	headpiece	NN
cord-001835-0s7ok4uw	3304	34	explicitly	explicitly	RB
cord-001835-0s7ok4uw	3304	35	[	[	-LRB-
cord-001835-0s7ok4uw	3304	36	1	1	CD
cord-001835-0s7ok4uw	3304	37	]	]	-RRB-
cord-001835-0s7ok4uw	3304	38	.	.	.
cord-001835-0s7ok4uw	3305	1	For	for	IN
cord-001835-0s7ok4uw	3305	2	considering	consider	VBG
cord-001835-0s7ok4uw	3305	3	vibrational	vibrational	JJ
cord-001835-0s7ok4uw	3305	4	entropy	entropy	NN
cord-001835-0s7ok4uw	3305	5	,	,	,
cord-001835-0s7ok4uw	3305	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	3305	7	suggest	suggest	VBP
cord-001835-0s7ok4uw	3305	8	a	a	DT
cord-001835-0s7ok4uw	3305	9	knowledge	knowledge	NN
cord-001835-0s7ok4uw	3305	10	based	base	VBN
cord-001835-0s7ok4uw	3305	11	approach	approach	NN
cord-001835-0s7ok4uw	3305	12	where	where	WRB
cord-001835-0s7ok4uw	3305	13	typical	typical	JJ
cord-001835-0s7ok4uw	3305	14	fluctuation	fluctuation	NN
cord-001835-0s7ok4uw	3305	15	and	and	CC
cord-001835-0s7ok4uw	3305	16	correlation	correlation	NN
cord-001835-0s7ok4uw	3305	17	patterns	pattern	NNS
cord-001835-0s7ok4uw	3305	18	are	be	VBP
cord-001835-0s7ok4uw	3305	19	extracted	extract	VBN
cord-001835-0s7ok4uw	3305	20	from	from	IN
cord-001835-0s7ok4uw	3305	21	known	know	VBN
cord-001835-0s7ok4uw	3305	22	proteins	protein	NNS
cord-001835-0s7ok4uw	3305	23	and	and	CC
cord-001835-0s7ok4uw	3305	24	then	then	RB
cord-001835-0s7ok4uw	3305	25	applied	apply	VBD
cord-001835-0s7ok4uw	3305	26	to	to	IN
cord-001835-0s7ok4uw	3305	27	new	new	JJ
cord-001835-0s7ok4uw	3305	28	targets	target	NNS
cord-001835-0s7ok4uw	3305	29	.	.	.
cord-001835-0s7ok4uw	3306	1	(	(	-LRB-
cord-001835-0s7ok4uw	3306	2	ii	ii	NN
cord-001835-0s7ok4uw	3306	3	)	)	-RRB-
cord-001835-0s7ok4uw	3307	1	At	at	IN
cord-001835-0s7ok4uw	3307	2	ambient	ambient	JJ
cord-001835-0s7ok4uw	3307	3	conditions	condition	NNS
cord-001835-0s7ok4uw	3307	4	,	,	,
cord-001835-0s7ok4uw	3307	5	timeaveraged	timeaveraged	JJ
cord-001835-0s7ok4uw	3307	6	potentials	potential	NNS
cord-001835-0s7ok4uw	3307	7	of	of	IN
cord-001835-0s7ok4uw	3307	8	proteins	protein	NNS
cord-001835-0s7ok4uw	3307	9	are	be	VBP
cord-001835-0s7ok4uw	3307	10	considerably	considerably	RB
cord-001835-0s7ok4uw	3307	11	smoothened	smoothen	VBN
cord-001835-0s7ok4uw	3307	12	due	due	IN
cord-001835-0s7ok4uw	3307	13	to	to	IN
cord-001835-0s7ok4uw	3307	14	thermal	thermal	JJ
cord-001835-0s7ok4uw	3307	15	motion	motion	NN
cord-001835-0s7ok4uw	3307	16	where	where	WRB
cord-001835-0s7ok4uw	3307	17	the	the	DT
cord-001835-0s7ok4uw	3307	18	strength	strength	NN
cord-001835-0s7ok4uw	3307	19	of	of	IN
cord-001835-0s7ok4uw	3307	20	this	this	DT
cord-001835-0s7ok4uw	3307	21	effect	effect	NN
cord-001835-0s7ok4uw	3307	22	varies	vary	VBZ
cord-001835-0s7ok4uw	3307	23	strongly	strongly	RB
cord-001835-0s7ok4uw	3307	24	between	between	IN
cord-001835-0s7ok4uw	3307	25	atoms	atom	NNS
cord-001835-0s7ok4uw	3307	26	.	.	.
cord-001835-0s7ok4uw	3308	1	Distinguishing	distinguish	VBG
cord-001835-0s7ok4uw	3308	2	these	these	DT
cord-001835-0s7ok4uw	3308	3	inhomogeneities	inhomogeneity	NNS
cord-001835-0s7ok4uw	3308	4	by	by	IN
cord-001835-0s7ok4uw	3308	5	introducing	introduce	VBG
cord-001835-0s7ok4uw	3308	6	new	new	JJ
cord-001835-0s7ok4uw	3308	7	atom	atom	NN
cord-001835-0s7ok4uw	3308	8	species	specie	NNS
cord-001835-0s7ok4uw	3308	9	regarding	regard	VBG
cord-001835-0s7ok4uw	3308	10	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3308	11	locale	locale	NN
cord-001835-0s7ok4uw	3308	12	environment	environment	NN
cord-001835-0s7ok4uw	3308	13	can	can	MD
cord-001835-0s7ok4uw	3308	14	therefore	therefore	RB
cord-001835-0s7ok4uw	3308	15	increase	increase	VB
cord-001835-0s7ok4uw	3308	16	the	the	DT
cord-001835-0s7ok4uw	3308	17	precision	precision	NN
cord-001835-0s7ok4uw	3308	18	of	of	IN
cord-001835-0s7ok4uw	3308	19	time	time	NN
cord-001835-0s7ok4uw	3308	20	-	-	HYPH
cord-001835-0s7ok4uw	3308	21	averaged	average	VBN
cord-001835-0s7ok4uw	3308	22	potentials	potential	NNS
cord-001835-0s7ok4uw	3308	23	[	[	-LRB-
cord-001835-0s7ok4uw	3308	24	2	2	CD
cord-001835-0s7ok4uw	3308	25	]	]	-RRB-
cord-001835-0s7ok4uw	3308	26	.	.	.
cord-001835-0s7ok4uw	3309	1	Extraction	extraction	NN
cord-001835-0s7ok4uw	3309	2	of	of	IN
cord-001835-0s7ok4uw	3309	3	general	general	JJ
cord-001835-0s7ok4uw	3309	4	principles	principle	NNS
cord-001835-0s7ok4uw	3309	5	from	from	IN
cord-001835-0s7ok4uw	3309	6	the	the	DT
cord-001835-0s7ok4uw	3309	7	continually	continually	RB
cord-001835-0s7ok4uw	3309	8	growing	grow	VBG
cord-001835-0s7ok4uw	3309	9	Protein	Protein	NNP
cord-001835-0s7ok4uw	3309	10	Data	Data	NNP
cord-001835-0s7ok4uw	3309	11	Bank	Bank	NNP
cord-001835-0s7ok4uw	3309	12	(	(	-LRB-
cord-001835-0s7ok4uw	3309	13	PDB	PDB	NNP
cord-001835-0s7ok4uw	3309	14	)	)	-RRB-
cord-001835-0s7ok4uw	3309	15	has	have	VBZ
cord-001835-0s7ok4uw	3309	16	been	be	VBN
cord-001835-0s7ok4uw	3309	17	a	a	DT
cord-001835-0s7ok4uw	3309	18	significant	significant	JJ
cord-001835-0s7ok4uw	3309	19	driving	drive	VBG
cord-001835-0s7ok4uw	3309	20	force	force	NN
cord-001835-0s7ok4uw	3309	21	in	in	IN
cord-001835-0s7ok4uw	3309	22	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3309	23	understanding	understanding	NN
cord-001835-0s7ok4uw	3309	24	of	of	IN
cord-001835-0s7ok4uw	3309	25	protein	protein	NN
cord-001835-0s7ok4uw	3309	26	structure	structure	NN
cord-001835-0s7ok4uw	3309	27	.	.	.
cord-001835-0s7ok4uw	3310	1	Atomistic	atomistic	JJ
cord-001835-0s7ok4uw	3310	2	or	or	CC
cord-001835-0s7ok4uw	3310	3	residue	residue	NN
cord-001835-0s7ok4uw	3310	4	-	-	HYPH
cord-001835-0s7ok4uw	3310	5	level	level	NN
cord-001835-0s7ok4uw	3310	6	statistical	statistical	JJ
cord-001835-0s7ok4uw	3310	7	potentials	potential	NNS
cord-001835-0s7ok4uw	3310	8	,	,	,
cord-001835-0s7ok4uw	3310	9	secondary	secondary	JJ
cord-001835-0s7ok4uw	3310	10	-	-	HYPH
cord-001835-0s7ok4uw	3310	11	structural	structural	JJ
cord-001835-0s7ok4uw	3310	12	propensities	propensity	NNS
cord-001835-0s7ok4uw	3310	13	,	,	,
cord-001835-0s7ok4uw	3310	14	and	and	CC
cord-001835-0s7ok4uw	3310	15	geometric	geometric	JJ
cord-001835-0s7ok4uw	3310	16	preferences	preference	NNS
cord-001835-0s7ok4uw	3310	17	for	for	IN
cord-001835-0s7ok4uw	3310	18	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3310	19	bonding	bonding	NN
cord-001835-0s7ok4uw	3310	20	are	be	VBP
cord-001835-0s7ok4uw	3310	21	among	among	IN
cord-001835-0s7ok4uw	3310	22	the	the	DT
cord-001835-0s7ok4uw	3310	23	classical	classical	JJ
cord-001835-0s7ok4uw	3310	24	insights	insight	NNS
cord-001835-0s7ok4uw	3310	25	that	that	WDT
cord-001835-0s7ok4uw	3310	26	arose	arise	VBD
cord-001835-0s7ok4uw	3310	27	from	from	IN
cord-001835-0s7ok4uw	3310	28	observations	observation	NNS
cord-001835-0s7ok4uw	3310	29	in	in	IN
cord-001835-0s7ok4uw	3310	30	the	the	DT
cord-001835-0s7ok4uw	3310	31	PDB	PDB	NNP
cord-001835-0s7ok4uw	3310	32	.	.	.
cord-001835-0s7ok4uw	3311	1	Given	give	VBN
cord-001835-0s7ok4uw	3311	2	the	the	DT
cord-001835-0s7ok4uw	3311	3	magnitude	magnitude	NN
cord-001835-0s7ok4uw	3311	4	of	of	IN
cord-001835-0s7ok4uw	3311	5	structural	structural	JJ
cord-001835-0s7ok4uw	3311	6	data	datum	NNS
cord-001835-0s7ok4uw	3311	7	available	available	JJ
cord-001835-0s7ok4uw	3311	8	today	today	NN
cord-001835-0s7ok4uw	3311	9	,	,	,
cord-001835-0s7ok4uw	3311	10	it	-PRON-	PRP
cord-001835-0s7ok4uw	3311	11	is	be	VBZ
cord-001835-0s7ok4uw	3311	12	likely	likely	JJ
cord-001835-0s7ok4uw	3311	13	that	that	IN
cord-001835-0s7ok4uw	3311	14	many	many	JJ
cord-001835-0s7ok4uw	3311	15	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	3311	16	generalizations	generalization	NNS
cord-001835-0s7ok4uw	3311	17	remain	remain	VBP
cord-001835-0s7ok4uw	3311	18	to	to	TO
cord-001835-0s7ok4uw	3311	19	be	be	VB
cord-001835-0s7ok4uw	3311	20	made	make	VBN
cord-001835-0s7ok4uw	3311	21	.	.	.
cord-001835-0s7ok4uw	3312	1	Here	here	RB
cord-001835-0s7ok4uw	3312	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3312	3	hypothesize	hypothesize	VBP
cord-001835-0s7ok4uw	3312	4	that	that	IN
cord-001835-0s7ok4uw	3312	5	the	the	DT
cord-001835-0s7ok4uw	3312	6	PDB	PDB	NNP
cord-001835-0s7ok4uw	3312	7	contains	contain	VBZ
cord-001835-0s7ok4uw	3312	8	valuable	valuable	JJ
cord-001835-0s7ok4uw	3312	9	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	3312	10	information	information	NN
cord-001835-0s7ok4uw	3312	11	on	on	IN
cord-001835-0s7ok4uw	3312	12	the	the	DT
cord-001835-0s7ok4uw	3312	13	level	level	NN
cord-001835-0s7ok4uw	3312	14	of	of	IN
cord-001835-0s7ok4uw	3312	15	local	local	JJ
cord-001835-0s7ok4uw	3312	16	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	3312	17	structural	structural	JJ
cord-001835-0s7ok4uw	3312	18	motifs	motif	NNS
cord-001835-0s7ok4uw	3312	19	(	(	-LRB-
cord-001835-0s7ok4uw	3312	20	TERMs	term	NNS
cord-001835-0s7ok4uw	3312	21	)	)	-RRB-
cord-001835-0s7ok4uw	3312	22	,	,	,
cord-001835-0s7ok4uw	3312	23	with	with	IN
cord-001835-0s7ok4uw	3312	24	TERM	term	NN
cord-001835-0s7ok4uw	3312	25	statistics	statistic	NNS
cord-001835-0s7ok4uw	3312	26	reflecting	reflect	VBG
cord-001835-0s7ok4uw	3312	27	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	3312	28	relationships	relationship	NNS
cord-001835-0s7ok4uw	3312	29	between	between	IN
cord-001835-0s7ok4uw	3312	30	sequence	sequence	NN
cord-001835-0s7ok4uw	3312	31	and	and	CC
cord-001835-0s7ok4uw	3312	32	structure	structure	NN
cord-001835-0s7ok4uw	3312	33	.	.	.
cord-001835-0s7ok4uw	3313	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3313	2	define	define	VBP
cord-001835-0s7ok4uw	3313	3	a	a	DT
cord-001835-0s7ok4uw	3313	4	TERM	term	NN
cord-001835-0s7ok4uw	3313	5	to	to	TO
cord-001835-0s7ok4uw	3313	6	be	be	VB
cord-001835-0s7ok4uw	3313	7	the	the	DT
cord-001835-0s7ok4uw	3313	8	structural	structural	JJ
cord-001835-0s7ok4uw	3313	9	fragment	fragment	NN
cord-001835-0s7ok4uw	3313	10	that	that	WDT
cord-001835-0s7ok4uw	3313	11	captures	capture	VBZ
cord-001835-0s7ok4uw	3313	12	the	the	DT
cord-001835-0s7ok4uw	3313	13	local	local	JJ
cord-001835-0s7ok4uw	3313	14	secondary	secondary	JJ
cord-001835-0s7ok4uw	3313	15	and	and	CC
cord-001835-0s7ok4uw	3313	16	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	3313	17	environments	environment	NNS
cord-001835-0s7ok4uw	3313	18	of	of	IN
cord-001835-0s7ok4uw	3313	19	a	a	DT
cord-001835-0s7ok4uw	3313	20	given	give	VBN
cord-001835-0s7ok4uw	3313	21	residue	residue	NN
cord-001835-0s7ok4uw	3313	22	,	,	,
cord-001835-0s7ok4uw	3313	23	and	and	CC
cord-001835-0s7ok4uw	3313	24	put	put	VBD
cord-001835-0s7ok4uw	3313	25	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3313	26	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	3313	27	through	through	IN
cord-001835-0s7ok4uw	3313	28	a	a	DT
cord-001835-0s7ok4uw	3313	29	series	series	NN
cord-001835-0s7ok4uw	3313	30	of	of	IN
cord-001835-0s7ok4uw	3313	31	rigorous	rigorous	JJ
cord-001835-0s7ok4uw	3313	32	tests	test	NNS
cord-001835-0s7ok4uw	3313	33	.	.	.
cord-001835-0s7ok4uw	3314	1	First	first	RB
cord-001835-0s7ok4uw	3314	2	,	,	,
cord-001835-0s7ok4uw	3314	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3314	4	show	show	VBP
cord-001835-0s7ok4uw	3314	5	that	that	IN
cord-001835-0s7ok4uw	3314	6	by	by	IN
cord-001835-0s7ok4uw	3314	7	breaking	break	VBG
cord-001835-0s7ok4uw	3314	8	a	a	DT
cord-001835-0s7ok4uw	3314	9	protein	protein	NN
cord-001835-0s7ok4uw	3314	10	structure	structure	NN
cord-001835-0s7ok4uw	3314	11	into	into	IN
cord-001835-0s7ok4uw	3314	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3314	13	constituent	constituent	NN
cord-001835-0s7ok4uw	3314	14	TERMs	term	NNS
cord-001835-0s7ok4uw	3314	15	,	,	,
cord-001835-0s7ok4uw	3314	16	and	and	CC
cord-001835-0s7ok4uw	3314	17	querying	query	VBG
cord-001835-0s7ok4uw	3314	18	the	the	DT
cord-001835-0s7ok4uw	3314	19	PDB	PDB	NNP
cord-001835-0s7ok4uw	3314	20	to	to	TO
cord-001835-0s7ok4uw	3314	21	characterize	characterize	VB
cord-001835-0s7ok4uw	3314	22	the	the	DT
cord-001835-0s7ok4uw	3314	23	natural	natural	JJ
cord-001835-0s7ok4uw	3314	24	ensemble	ensemble	NN
cord-001835-0s7ok4uw	3314	25	around	around	IN
cord-001835-0s7ok4uw	3314	26	each	each	DT
cord-001835-0s7ok4uw	3314	27	,	,	,
cord-001835-0s7ok4uw	3314	28	we	-PRON-	PRP
cord-001835-0s7ok4uw	3314	29	can	can	MD
cord-001835-0s7ok4uw	3314	30	estimate	estimate	VB
cord-001835-0s7ok4uw	3314	31	the	the	DT
cord-001835-0s7ok4uw	3314	32	compatibility	compatibility	NN
cord-001835-0s7ok4uw	3314	33	of	of	IN
cord-001835-0s7ok4uw	3314	34	the	the	DT
cord-001835-0s7ok4uw	3314	35	structure	structure	NN
cord-001835-0s7ok4uw	3314	36	with	with	IN
cord-001835-0s7ok4uw	3314	37	a	a	DT
cord-001835-0s7ok4uw	3314	38	given	give	VBN
cord-001835-0s7ok4uw	3314	39	amino	amino	NN
cord-001835-0s7ok4uw	3314	40	-	-	HYPH
cord-001835-0s7ok4uw	3314	41	acid	acid	NN
cord-001835-0s7ok4uw	3314	42	sequence	sequence	NN
cord-001835-0s7ok4uw	3314	43	through	through	IN
cord-001835-0s7ok4uw	3314	44	a	a	DT
cord-001835-0s7ok4uw	3314	45	metric	metric	NN
cord-001835-0s7ok4uw	3314	46	we	-PRON-	PRP
cord-001835-0s7ok4uw	3314	47	term	term	NN
cord-001835-0s7ok4uw	3314	48	"	"	''
cord-001835-0s7ok4uw	3314	49	structure	structure	NN
cord-001835-0s7ok4uw	3314	50	score	score	NN
cord-001835-0s7ok4uw	3314	51	.	.	.
cord-001835-0s7ok4uw	3314	52	"	"	''
cord-001835-0s7ok4uw	3315	1	Considering	consider	VBG
cord-001835-0s7ok4uw	3315	2	submissions	submission	NNS
cord-001835-0s7ok4uw	3315	3	from	from	IN
cord-001835-0s7ok4uw	3315	4	recent	recent	JJ
cord-001835-0s7ok4uw	3315	5	Critical	Critical	NNP
cord-001835-0s7ok4uw	3315	6	Assessment	Assessment	NNP
cord-001835-0s7ok4uw	3315	7	of	of	IN
cord-001835-0s7ok4uw	3315	8	Structure	Structure	NNP
cord-001835-0s7ok4uw	3315	9	Prediction	Prediction	NNP
cord-001835-0s7ok4uw	3315	10	(	(	-LRB-
cord-001835-0s7ok4uw	3315	11	CASP	CASP	NNP
cord-001835-0s7ok4uw	3315	12	)	)	-RRB-
cord-001835-0s7ok4uw	3315	13	experiments	experiment	NNS
cord-001835-0s7ok4uw	3315	14	,	,	,
cord-001835-0s7ok4uw	3315	15	we	-PRON-	PRP
cord-001835-0s7ok4uw	3315	16	find	find	VBP
cord-001835-0s7ok4uw	3315	17	a	a	DT
cord-001835-0s7ok4uw	3315	18	strong	strong	JJ
cord-001835-0s7ok4uw	3315	19	correlation	correlation	NN
cord-001835-0s7ok4uw	3315	20	(	(	-LRB-
cord-001835-0s7ok4uw	3315	21	R	r	NN
cord-001835-0s7ok4uw	3315	22	5	5	CD
cord-001835-0s7ok4uw	3315	23	0.69	0.69	CD
cord-001835-0s7ok4uw	3315	24	)	)	-RRB-
cord-001835-0s7ok4uw	3315	25	between	between	IN
cord-001835-0s7ok4uw	3315	26	structure	structure	NN
cord-001835-0s7ok4uw	3315	27	score	score	NN
cord-001835-0s7ok4uw	3315	28	and	and	CC
cord-001835-0s7ok4uw	3315	29	model	model	NN
cord-001835-0s7ok4uw	3315	30	accuracy	accuracy	NN
cord-001835-0s7ok4uw	3315	31	,	,	,
cord-001835-0s7ok4uw	3315	32	with	with	IN
cord-001835-0s7ok4uw	3315	33	poorly	poorly	RB
cord-001835-0s7ok4uw	3315	34	predicted	predict	VBN
cord-001835-0s7ok4uw	3315	35	regions	region	NNS
cord-001835-0s7ok4uw	3315	36	readily	readily	RB
cord-001835-0s7ok4uw	3315	37	identifiable	identifiable	JJ
cord-001835-0s7ok4uw	3315	38	.	.	.
cord-001835-0s7ok4uw	3316	1	This	this	DT
cord-001835-0s7ok4uw	3316	2	performance	performance	NN
cord-001835-0s7ok4uw	3316	3	exceeds	exceed	VBZ
cord-001835-0s7ok4uw	3316	4	that	that	DT
cord-001835-0s7ok4uw	3316	5	of	of	IN
cord-001835-0s7ok4uw	3316	6	leading	lead	VBG
cord-001835-0s7ok4uw	3316	7	atomistic	atomistic	JJ
cord-001835-0s7ok4uw	3316	8	statistical	statistical	JJ
cord-001835-0s7ok4uw	3316	9	energy	energy	NN
cord-001835-0s7ok4uw	3316	10	functions	function	NNS
cord-001835-0s7ok4uw	3316	11	.	.	.
cord-001835-0s7ok4uw	3317	1	Next	next	RB
cord-001835-0s7ok4uw	3317	2	,	,	,
cord-001835-0s7ok4uw	3317	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3317	4	show	show	VBP
cord-001835-0s7ok4uw	3317	5	that	that	IN
cord-001835-0s7ok4uw	3317	6	by	by	IN
cord-001835-0s7ok4uw	3317	7	considering	consider	VBG
cord-001835-0s7ok4uw	3317	8	the	the	DT
cord-001835-0s7ok4uw	3317	9	TERMs	term	NNS
cord-001835-0s7ok4uw	3317	10	of	of	IN
cord-001835-0s7ok4uw	3317	11	a	a	DT
cord-001835-0s7ok4uw	3317	12	structure	structure	NN
cord-001835-0s7ok4uw	3317	13	that	that	WDT
cord-001835-0s7ok4uw	3317	14	are	be	VBP
cord-001835-0s7ok4uw	3317	15	affected	affect	VBN
cord-001835-0s7ok4uw	3317	16	by	by	IN
cord-001835-0s7ok4uw	3317	17	a	a	DT
cord-001835-0s7ok4uw	3317	18	given	give	VBN
cord-001835-0s7ok4uw	3317	19	mutation	mutation	NN
cord-001835-0s7ok4uw	3317	20	,	,	,
cord-001835-0s7ok4uw	3317	21	and	and	CC
cord-001835-0s7ok4uw	3317	22	mining	mine	VBG
cord-001835-0s7ok4uw	3317	23	the	the	DT
cord-001835-0s7ok4uw	3317	24	PDB	PDB	NNP
cord-001835-0s7ok4uw	3317	25	to	to	TO
cord-001835-0s7ok4uw	3317	26	characterize	characterize	VB
cord-001835-0s7ok4uw	3317	27	sequence	sequence	NN
cord-001835-0s7ok4uw	3317	28	statistics	statistic	NNS
cord-001835-0s7ok4uw	3317	29	associated	associate	VBN
cord-001835-0s7ok4uw	3317	30	with	with	IN
cord-001835-0s7ok4uw	3317	31	each	each	DT
cord-001835-0s7ok4uw	3317	32	,	,	,
cord-001835-0s7ok4uw	3317	33	we	-PRON-	PRP
cord-001835-0s7ok4uw	3317	34	are	be	VBP
cord-001835-0s7ok4uw	3317	35	able	able	JJ
cord-001835-0s7ok4uw	3317	36	to	to	TO
cord-001835-0s7ok4uw	3317	37	predict	predict	VB
cord-001835-0s7ok4uw	3317	38	mutational	mutational	JJ
cord-001835-0s7ok4uw	3317	39	free	free	JJ
cord-001835-0s7ok4uw	3317	40	energies	energy	NNS
cord-001835-0s7ok4uw	3317	41	on	on	IN
cord-001835-0s7ok4uw	3317	42	par	par	NN
cord-001835-0s7ok4uw	3317	43	with	with	IN
cord-001835-0s7ok4uw	3317	44	or	or	CC
cord-001835-0s7ok4uw	3317	45	better	well	JJR
cord-001835-0s7ok4uw	3317	46	than	than	IN
cord-001835-0s7ok4uw	3317	47	far	far	RB
cord-001835-0s7ok4uw	3317	48	more	more	RBR
cord-001835-0s7ok4uw	3317	49	sophisticated	sophisticated	JJ
cord-001835-0s7ok4uw	3317	50	atomistic	atomistic	JJ
cord-001835-0s7ok4uw	3317	51	energy	energy	NN
cord-001835-0s7ok4uw	3317	52	functions	function	NNS
cord-001835-0s7ok4uw	3317	53	.	.	.
cord-001835-0s7ok4uw	3318	1	Finally	finally	RB
cord-001835-0s7ok4uw	3318	2	,	,	,
cord-001835-0s7ok4uw	3318	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3318	4	ask	ask	VBP
cord-001835-0s7ok4uw	3318	5	whether	whether	IN
cord-001835-0s7ok4uw	3318	6	TERM	term	NN
cord-001835-0s7ok4uw	3318	7	statistics	statistic	NNS
cord-001835-0s7ok4uw	3318	8	are	be	VBP
cord-001835-0s7ok4uw	3318	9	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	3318	10	to	to	TO
cord-001835-0s7ok4uw	3318	11	enable	enable	VB
cord-001835-0s7ok4uw	3318	12	the	the	DT
cord-001835-0s7ok4uw	3318	13	design	design	NN
cord-001835-0s7ok4uw	3318	14	of	of	IN
cord-001835-0s7ok4uw	3318	15	proteins	protein	NNS
cord-001835-0s7ok4uw	3318	16	de	de	NNP
cord-001835-0s7ok4uw	3318	17	-	-	HYPH
cord-001835-0s7ok4uw	3318	18	novo	novo	NNP
cord-001835-0s7ok4uw	3318	19	.	.	.
cord-001835-0s7ok4uw	3319	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3319	2	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	3319	3	that	that	IN
cord-001835-0s7ok4uw	3319	4	given	give	VBN
cord-001835-0s7ok4uw	3319	5	a	a	DT
cord-001835-0s7ok4uw	3319	6	native	native	JJ
cord-001835-0s7ok4uw	3319	7	backbone	backbone	NN
cord-001835-0s7ok4uw	3319	8	conformation	conformation	NN
cord-001835-0s7ok4uw	3319	9	,	,	,
cord-001835-0s7ok4uw	3319	10	TERM	term	NN
cord-001835-0s7ok4uw	3319	11	considerations	consideration	NNS
cord-001835-0s7ok4uw	3319	12	alone	alone	RB
cord-001835-0s7ok4uw	3319	13	with	with	IN
cord-001835-0s7ok4uw	3319	14	no	no	DT
cord-001835-0s7ok4uw	3319	15	input	input	NN
cord-001835-0s7ok4uw	3319	16	from	from	IN
cord-001835-0s7ok4uw	3319	17	molecular	molecular	JJ
cord-001835-0s7ok4uw	3319	18	mechanics	mechanic	NNS
cord-001835-0s7ok4uw	3319	19	correctly	correctly	RB
cord-001835-0s7ok4uw	3319	20	predict	predict	VBP
cord-001835-0s7ok4uw	3319	21	roughly	roughly	RB
cord-001835-0s7ok4uw	3319	22	the	the	DT
cord-001835-0s7ok4uw	3319	23	same	same	JJ
cord-001835-0s7ok4uw	3319	24	fraction	fraction	NN
cord-001835-0s7ok4uw	3319	25	of	of	IN
cord-001835-0s7ok4uw	3319	26	amino	amino	JJ
cord-001835-0s7ok4uw	3319	27	acids	acid	NNS
cord-001835-0s7ok4uw	3319	28	from	from	IN
cord-001835-0s7ok4uw	3319	29	the	the	DT
cord-001835-0s7ok4uw	3319	30	corresponding	corresponding	JJ
cord-001835-0s7ok4uw	3319	31	native	native	JJ
cord-001835-0s7ok4uw	3319	32	sequence	sequence	NN
cord-001835-0s7ok4uw	3319	33	as	as	IN
cord-001835-0s7ok4uw	3319	34	state	state	NN
cord-001835-0s7ok4uw	3319	35	-	-	HYPH
cord-001835-0s7ok4uw	3319	36	ofthe	ofthe	DT
cord-001835-0s7ok4uw	3319	37	-	-	HYPH
cord-001835-0s7ok4uw	3319	38	art	art	NN
cord-001835-0s7ok4uw	3319	39	computational	computational	JJ
cord-001835-0s7ok4uw	3319	40	protein	protein	NN
cord-001835-0s7ok4uw	3319	41	design	design	NN
cord-001835-0s7ok4uw	3319	42	methods	method	NNS
cord-001835-0s7ok4uw	3319	43	.	.	.
cord-001835-0s7ok4uw	3320	1	Knowledge	knowledge	NN
cord-001835-0s7ok4uw	3320	2	-	-	HYPH
cord-001835-0s7ok4uw	3320	3	based	base	VBN
cord-001835-0s7ok4uw	3320	4	energy	energy	NN
cord-001835-0s7ok4uw	3320	5	functions	function	NNS
cord-001835-0s7ok4uw	3320	6	have	have	VBP
cord-001835-0s7ok4uw	3320	7	already	already	RB
cord-001835-0s7ok4uw	3320	8	put	put	VBN
cord-001835-0s7ok4uw	3320	9	PDB	PDB	NNP
cord-001835-0s7ok4uw	3320	10	statistics	statistic	NNS
cord-001835-0s7ok4uw	3320	11	to	to	IN
cord-001835-0s7ok4uw	3320	12	good	good	JJ
cord-001835-0s7ok4uw	3320	13	use	use	NN
cord-001835-0s7ok4uw	3320	14	by	by	IN
cord-001835-0s7ok4uw	3320	15	parsing	parse	VBG
cord-001835-0s7ok4uw	3320	16	structural	structural	JJ
cord-001835-0s7ok4uw	3320	17	environments	environment	NNS
cord-001835-0s7ok4uw	3320	18	into	into	IN
cord-001835-0s7ok4uw	3320	19	geometric	geometric	JJ
cord-001835-0s7ok4uw	3320	20	descriptors	descriptor	NNS
cord-001835-0s7ok4uw	3320	21	,	,	,
cord-001835-0s7ok4uw	3320	22	generally	generally	RB
cord-001835-0s7ok4uw	3320	23	assuming	assume	VBG
cord-001835-0s7ok4uw	3320	24	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3320	25	conditional	conditional	JJ
cord-001835-0s7ok4uw	3320	26	independence	independence	NN
cord-001835-0s7ok4uw	3320	27	.	.	.
cord-001835-0s7ok4uw	3321	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3321	2	results	result	NNS
cord-001835-0s7ok4uw	3321	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	3321	4	that	that	IN
cord-001835-0s7ok4uw	3321	5	it	-PRON-	PRP
cord-001835-0s7ok4uw	3321	6	may	may	MD
cord-001835-0s7ok4uw	3321	7	now	now	RB
cord-001835-0s7ok4uw	3321	8	be	be	VB
cord-001835-0s7ok4uw	3321	9	possible	possible	JJ
cord-001835-0s7ok4uw	3321	10	to	to	TO
cord-001835-0s7ok4uw	3321	11	instead	instead	RB
cord-001835-0s7ok4uw	3321	12	consider	consider	VB
cord-001835-0s7ok4uw	3321	13	local	local	JJ
cord-001835-0s7ok4uw	3321	14	structural	structural	JJ
cord-001835-0s7ok4uw	3321	15	environments	environment	NNS
cord-001835-0s7ok4uw	3321	16	in	in	IN
cord-001835-0s7ok4uw	3321	17	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3321	18	entirety	entirety	NN
cord-001835-0s7ok4uw	3321	19	,	,	,
cord-001835-0s7ok4uw	3321	20	asking	ask	VBG
cord-001835-0s7ok4uw	3321	21	questions	question	NNS
cord-001835-0s7ok4uw	3321	22	about	about	IN
cord-001835-0s7ok4uw	3321	23	them	-PRON-	PRP
cord-001835-0s7ok4uw	3321	24	directly	directly	RB
cord-001835-0s7ok4uw	3321	25	.	.	.
cord-001835-0s7ok4uw	3322	1	If	if	IN
cord-001835-0s7ok4uw	3322	2	this	this	DT
cord-001835-0s7ok4uw	3322	3	is	be	VBZ
cord-001835-0s7ok4uw	3322	4	the	the	DT
cord-001835-0s7ok4uw	3322	5	case	case	NN
cord-001835-0s7ok4uw	3322	6	,	,	,
cord-001835-0s7ok4uw	3322	7	then	then	RB
cord-001835-0s7ok4uw	3322	8	the	the	DT
cord-001835-0s7ok4uw	3322	9	PDB	PDB	NNP
cord-001835-0s7ok4uw	3322	10	is	be	VBZ
cord-001835-0s7ok4uw	3322	11	an	an	DT
cord-001835-0s7ok4uw	3322	12	even	even	RB
cord-001835-0s7ok4uw	3322	13	larger	large	JJR
cord-001835-0s7ok4uw	3322	14	treasure	treasure	NN
cord-001835-0s7ok4uw	3322	15	trove	trove	NN
cord-001835-0s7ok4uw	3322	16	of	of	IN
cord-001835-0s7ok4uw	3322	17	information	information	NN
cord-001835-0s7ok4uw	3322	18	than	than	IN
cord-001835-0s7ok4uw	3322	19	it	-PRON-	PRP
cord-001835-0s7ok4uw	3322	20	has	have	VBZ
cord-001835-0s7ok4uw	3322	21	been	be	VBN
cord-001835-0s7ok4uw	3322	22	generally	generally	RB
cord-001835-0s7ok4uw	3322	23	known	know	VBN
cord-001835-0s7ok4uw	3322	24	to	to	TO
cord-001835-0s7ok4uw	3322	25	be	be	VB
cord-001835-0s7ok4uw	3322	26	,	,	,
cord-001835-0s7ok4uw	3322	27	and	and	CC
cord-001835-0s7ok4uw	3322	28	methods	method	NNS
cord-001835-0s7ok4uw	3322	29	of	of	IN
cord-001835-0s7ok4uw	3322	30	mining	mine	VBG
cord-001835-0s7ok4uw	3322	31	it	-PRON-	PRP
cord-001835-0s7ok4uw	3322	32	for	for	IN
cord-001835-0s7ok4uw	3322	33	TERM	term	NN
cord-001835-0s7ok4uw	3322	34	-	-	HYPH
cord-001835-0s7ok4uw	3322	35	based	base	VBN
cord-001835-0s7ok4uw	3322	36	statistics	statistic	NNS
cord-001835-0s7ok4uw	3322	37	should	should	MD
cord-001835-0s7ok4uw	3322	38	present	present	VB
cord-001835-0s7ok4uw	3322	39	opportunities	opportunity	NNS
cord-001835-0s7ok4uw	3322	40	for	for	IN
cord-001835-0s7ok4uw	3322	41	advances	advance	NNS
cord-001835-0s7ok4uw	3322	42	in	in	IN
cord-001835-0s7ok4uw	3322	43	structure	structure	NN
cord-001835-0s7ok4uw	3322	44	prediction	prediction	NN
cord-001835-0s7ok4uw	3322	45	and	and	CC
cord-001835-0s7ok4uw	3322	46	protein	protein	NN
cord-001835-0s7ok4uw	3322	47	design	design	NN
cord-001835-0s7ok4uw	3322	48	.	.	.
cord-001835-0s7ok4uw	3323	1	Comprehensive	comprehensive	JJ
cord-001835-0s7ok4uw	3323	2	understanding	understanding	NN
cord-001835-0s7ok4uw	3323	3	of	of	IN
cord-001835-0s7ok4uw	3323	4	a	a	DT
cord-001835-0s7ok4uw	3323	5	protein	protein	NN
cord-001835-0s7ok4uw	3323	6	fold	fold	NN
cord-001835-0s7ok4uw	3323	7	is	be	VBZ
cord-001835-0s7ok4uw	3323	8	intertwined	intertwine	VBN
cord-001835-0s7ok4uw	3323	9	with	with	IN
cord-001835-0s7ok4uw	3323	10	successful	successful	JJ
cord-001835-0s7ok4uw	3323	11	design	design	NN
cord-001835-0s7ok4uw	3323	12	.	.	.
cord-001835-0s7ok4uw	3324	1	Recent	recent	JJ
cord-001835-0s7ok4uw	3324	2	advances	advance	NNS
cord-001835-0s7ok4uw	3324	3	in	in	IN
cord-001835-0s7ok4uw	3324	4	designing	design	VBG
cord-001835-0s7ok4uw	3324	5	de	de	FW
cord-001835-0s7ok4uw	3324	6	novo	novo	NN
cord-001835-0s7ok4uw	3324	7	structures	structure	NNS
cord-001835-0s7ok4uw	3324	8	have	have	VBP
cord-001835-0s7ok4uw	3324	9	shown	show	VBN
cord-001835-0s7ok4uw	3324	10	that	that	IN
cord-001835-0s7ok4uw	3324	11	proteins	protein	NNS
cord-001835-0s7ok4uw	3324	12	can	can	MD
cord-001835-0s7ok4uw	3324	13	be	be	VB
cord-001835-0s7ok4uw	3324	14	designed	design	VBN
cord-001835-0s7ok4uw	3324	15	for	for	IN
cord-001835-0s7ok4uw	3324	16	a	a	DT
cord-001835-0s7ok4uw	3324	17	few	few	JJ
cord-001835-0s7ok4uw	3324	18	globular	globular	JJ
cord-001835-0s7ok4uw	3324	19	and	and	CC
cord-001835-0s7ok4uw	3324	20	helical	helical	JJ
cord-001835-0s7ok4uw	3324	21	folds	fold	NNS
cord-001835-0s7ok4uw	3324	22	.	.	.
cord-001835-0s7ok4uw	3325	1	However	however	RB
cord-001835-0s7ok4uw	3325	2	,	,	,
cord-001835-0s7ok4uw	3325	3	designing	design	VBG
cord-001835-0s7ok4uw	3325	4	all	all	RB
cord-001835-0s7ok4uw	3325	5	-	-	HYPH
cord-001835-0s7ok4uw	3325	6	b	b	NN
cord-001835-0s7ok4uw	3325	7	structures	structure	NNS
cord-001835-0s7ok4uw	3325	8	and	and	CC
cord-001835-0s7ok4uw	3325	9	barrels	barrel	NNS
cord-001835-0s7ok4uw	3325	10	remains	remain	VBZ
cord-001835-0s7ok4uw	3325	11	challenging	challenging	JJ
cord-001835-0s7ok4uw	3325	12	because	because	IN
cord-001835-0s7ok4uw	3325	13	loops	loop	NNS
cord-001835-0s7ok4uw	3325	14	and	and	CC
cord-001835-0s7ok4uw	3325	15	intricate	intricate	JJ
cord-001835-0s7ok4uw	3325	16	long	long	JJ
cord-001835-0s7ok4uw	3325	17	range	range	NN
cord-001835-0s7ok4uw	3325	18	interactions	interaction	NNS
cord-001835-0s7ok4uw	3325	19	that	that	WDT
cord-001835-0s7ok4uw	3325	20	are	be	VBP
cord-001835-0s7ok4uw	3325	21	important	important	JJ
cord-001835-0s7ok4uw	3325	22	in	in	IN
cord-001835-0s7ok4uw	3325	23	these	these	DT
cord-001835-0s7ok4uw	3325	24	topologies	topology	NNS
cord-001835-0s7ok4uw	3325	25	are	be	VBP
cord-001835-0s7ok4uw	3325	26	difficult	difficult	JJ
cord-001835-0s7ok4uw	3325	27	to	to	TO
cord-001835-0s7ok4uw	3325	28	control	control	VB
cord-001835-0s7ok4uw	3325	29	.	.	.
cord-001835-0s7ok4uw	3326	1	For	for	IN
cord-001835-0s7ok4uw	3326	2	designing	design	VBG
cord-001835-0s7ok4uw	3326	3	novel	novel	JJ
cord-001835-0s7ok4uw	3326	4	catalysts	catalyst	NNS
cord-001835-0s7ok4uw	3326	5	,	,	,
cord-001835-0s7ok4uw	3326	6	the	the	DT
cord-001835-0s7ok4uw	3326	7	(	(	-LRB-
cord-001835-0s7ok4uw	3326	8	a	a	DT
cord-001835-0s7ok4uw	3326	9	/	/	SYM
cord-001835-0s7ok4uw	3326	10	b)8	b)8	NN
cord-001835-0s7ok4uw	3326	11	-barrel	-barrel	:
cord-001835-0s7ok4uw	3326	12	(	(	-LRB-
cord-001835-0s7ok4uw	3326	13	or	or	CC
cord-001835-0s7ok4uw	3326	14	TIM	TIM	NNP
cord-001835-0s7ok4uw	3326	15	-	-	HYPH
cord-001835-0s7ok4uw	3326	16	barrel	barrel	NN
cord-001835-0s7ok4uw	3326	17	)	)	-RRB-
cord-001835-0s7ok4uw	3326	18	fold	fold	NN
cord-001835-0s7ok4uw	3326	19	is	be	VBZ
cord-001835-0s7ok4uw	3326	20	one	one	CD
cord-001835-0s7ok4uw	3326	21	of	of	IN
cord-001835-0s7ok4uw	3326	22	the	the	DT
cord-001835-0s7ok4uw	3326	23	most	most	RBS
cord-001835-0s7ok4uw	3326	24	important	important	JJ
cord-001835-0s7ok4uw	3326	25	examples	example	NNS
cord-001835-0s7ok4uw	3326	26	,	,	,
cord-001835-0s7ok4uw	3326	27	for	for	IN
cord-001835-0s7ok4uw	3326	28	it	-PRON-	PRP
cord-001835-0s7ok4uw	3326	29	is	be	VBZ
cord-001835-0s7ok4uw	3326	30	the	the	DT
cord-001835-0s7ok4uw	3326	31	most	most	RBS
cord-001835-0s7ok4uw	3326	32	common	common	JJ
cord-001835-0s7ok4uw	3326	33	topology	topology	NN
cord-001835-0s7ok4uw	3326	34	for	for	IN
cord-001835-0s7ok4uw	3326	35	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3326	36	.	.	.
cord-001835-0s7ok4uw	3327	1	For	for	IN
cord-001835-0s7ok4uw	3327	2	almost	almost	RB
cord-001835-0s7ok4uw	3327	3	30	30	CD
cord-001835-0s7ok4uw	3327	4	year	year	NN
cord-001835-0s7ok4uw	3327	5	,	,	,
cord-001835-0s7ok4uw	3327	6	attempts	attempt	NNS
cord-001835-0s7ok4uw	3327	7	in	in	IN
cord-001835-0s7ok4uw	3327	8	designing	design	VBG
cord-001835-0s7ok4uw	3327	9	de	de	FW
cord-001835-0s7ok4uw	3327	10	novo	novo	NNP
cord-001835-0s7ok4uw	3327	11	TIM	TIM	NNP
cord-001835-0s7ok4uw	3327	12	barrel	barrel	NN
cord-001835-0s7ok4uw	3327	13	structures	structure	NNS
cord-001835-0s7ok4uw	3327	14	have	have	VBP
cord-001835-0s7ok4uw	3327	15	all	all	DT
cord-001835-0s7ok4uw	3327	16	resulted	result	VBN
cord-001835-0s7ok4uw	3327	17	in	in	IN
cord-001835-0s7ok4uw	3327	18	poorly	poorly	RB
cord-001835-0s7ok4uw	3327	19	folded	fold	VBN
cord-001835-0s7ok4uw	3327	20	proteins	protein	NNS
cord-001835-0s7ok4uw	3327	21	.	.	.
cord-001835-0s7ok4uw	3328	1	Here	here	RB
cord-001835-0s7ok4uw	3328	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3328	3	describe	describe	VBP
cord-001835-0s7ok4uw	3328	4	the	the	DT
cord-001835-0s7ok4uw	3328	5	successful	successful	JJ
cord-001835-0s7ok4uw	3328	6	design	design	NN
cord-001835-0s7ok4uw	3328	7	of	of	IN
cord-001835-0s7ok4uw	3328	8	a	a	DT
cord-001835-0s7ok4uw	3328	9	4-fold	4-fold	CD
cord-001835-0s7ok4uw	3328	10	symmetrical	symmetrical	JJ
cord-001835-0s7ok4uw	3328	11	(	(	-LRB-
cord-001835-0s7ok4uw	3328	12	a	a	DT
cord-001835-0s7ok4uw	3328	13	/	/	SYM
cord-001835-0s7ok4uw	3328	14	b)8	b)8	JJ
cord-001835-0s7ok4uw	3328	15	barrel	barrel	NN
cord-001835-0s7ok4uw	3328	16	directly	directly	RB
cord-001835-0s7ok4uw	3328	17	from	from	IN
cord-001835-0s7ok4uw	3328	18	geometrical	geometrical	JJ
cord-001835-0s7ok4uw	3328	19	and	and	CC
cord-001835-0s7ok4uw	3328	20	chemical	chemical	JJ
cord-001835-0s7ok4uw	3328	21	principles	principle	NNS
cord-001835-0s7ok4uw	3328	22	.	.	.
cord-001835-0s7ok4uw	3329	1	22	22	CD
cord-001835-0s7ok4uw	3329	2	designed	design	VBN
cord-001835-0s7ok4uw	3329	3	variants	variant	NNS
cord-001835-0s7ok4uw	3329	4	with	with	IN
cord-001835-0s7ok4uw	3329	5	a	a	DT
cord-001835-0s7ok4uw	3329	6	wide	wide	JJ
cord-001835-0s7ok4uw	3329	7	range	range	NN
cord-001835-0s7ok4uw	3329	8	of	of	IN
cord-001835-0s7ok4uw	3329	9	stabilities	stability	NNS
cord-001835-0s7ok4uw	3329	10	from	from	IN
cord-001835-0s7ok4uw	3329	11	being	be	VBG
cord-001835-0s7ok4uw	3329	12	molten	molten	JJ
cord-001835-0s7ok4uw	3329	13	globules	globule	NNS
cord-001835-0s7ok4uw	3329	14	to	to	IN
cord-001835-0s7ok4uw	3329	15	cooperatively	cooperatively	RB
cord-001835-0s7ok4uw	3329	16	folded	fold	VBN
cord-001835-0s7ok4uw	3329	17	proteins	protein	NNS
cord-001835-0s7ok4uw	3329	18	were	be	VBD
cord-001835-0s7ok4uw	3329	19	experimentally	experimentally	RB
cord-001835-0s7ok4uw	3329	20	characterized	characterize	VBN
cord-001835-0s7ok4uw	3329	21	,	,	,
cord-001835-0s7ok4uw	3329	22	and	and	CC
cord-001835-0s7ok4uw	3329	23	the	the	DT
cord-001835-0s7ok4uw	3329	24	results	result	NNS
cord-001835-0s7ok4uw	3329	25	revealed	reveal	VBD
cord-001835-0s7ok4uw	3329	26	the	the	DT
cord-001835-0s7ok4uw	3329	27	importance	importance	NN
cord-001835-0s7ok4uw	3329	28	of	of	IN
cord-001835-0s7ok4uw	3329	29	sidechain	sidechain	NN
cord-001835-0s7ok4uw	3329	30	-	-	HYPH
cord-001835-0s7ok4uw	3329	31	backbone	backbone	NN
cord-001835-0s7ok4uw	3329	32	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3329	33	bonding	bonding	NN
cord-001835-0s7ok4uw	3329	34	for	for	IN
cord-001835-0s7ok4uw	3329	35	defining	define	VBG
cord-001835-0s7ok4uw	3329	36	the	the	DT
cord-001835-0s7ok4uw	3329	37	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	3329	38	a	a	NN
cord-001835-0s7ok4uw	3329	39	/	/	SYM
cord-001835-0s7ok4uw	3329	40	b	b	NN
cord-001835-0s7ok4uw	3329	41	-	-	HYPH
cord-001835-0s7ok4uw	3329	42	barrel	barrel	NN
cord-001835-0s7ok4uw	3329	43	.	.	.
cord-001835-0s7ok4uw	3330	1	The	the	DT
cord-001835-0s7ok4uw	3330	2	184	184	CD
cord-001835-0s7ok4uw	3330	3	residue	residue	NN
cord-001835-0s7ok4uw	3330	4	TIM	TIM	NNP
cord-001835-0s7ok4uw	3330	5	barrel	barrel	NN
cord-001835-0s7ok4uw	3330	6	structure	structure	NN
cord-001835-0s7ok4uw	3330	7	is	be	VBZ
cord-001835-0s7ok4uw	3330	8	among	among	IN
cord-001835-0s7ok4uw	3330	9	the	the	DT
cord-001835-0s7ok4uw	3330	10	smallest	small	JJS
cord-001835-0s7ok4uw	3330	11	TIM	TIM	NNP
cord-001835-0s7ok4uw	3330	12	-	-	HYPH
cord-001835-0s7ok4uw	3330	13	barrels	barrel	NNS
cord-001835-0s7ok4uw	3330	14	and	and	CC
cord-001835-0s7ok4uw	3330	15	has	have	VBZ
cord-001835-0s7ok4uw	3330	16	a	a	DT
cord-001835-0s7ok4uw	3330	17	fully	fully	RB
cord-001835-0s7ok4uw	3330	18	-	-	HYPH
cord-001835-0s7ok4uw	3330	19	reversible	reversible	JJ
cord-001835-0s7ok4uw	3330	20	melting	melting	NN
cord-001835-0s7ok4uw	3330	21	temperature	temperature	NN
cord-001835-0s7ok4uw	3330	22	of	of	IN
cord-001835-0s7ok4uw	3330	23	888C.	888c.	CD
cord-001835-0s7ok4uw	3331	1	The	the	DT
cord-001835-0s7ok4uw	3331	2	X	x	NN
cord-001835-0s7ok4uw	3331	3	-	-	NN
cord-001835-0s7ok4uw	3331	4	ray	ray	NN
cord-001835-0s7ok4uw	3331	5	crystal	crystal	NN
cord-001835-0s7ok4uw	3331	6	structure	structure	NN
cord-001835-0s7ok4uw	3331	7	shows	show	VBZ
cord-001835-0s7ok4uw	3331	8	atomic	atomic	JJ
cord-001835-0s7ok4uw	3331	9	-	-	HYPH
cord-001835-0s7ok4uw	3331	10	level	level	NN
cord-001835-0s7ok4uw	3331	11	agreement	agreement	NN
cord-001835-0s7ok4uw	3331	12	with	with	IN
cord-001835-0s7ok4uw	3331	13	the	the	DT
cord-001835-0s7ok4uw	3331	14	design	design	NN
cord-001835-0s7ok4uw	3331	15	model	model	NN
cord-001835-0s7ok4uw	3331	16	.	.	.
cord-001835-0s7ok4uw	3332	1	Despite	despite	IN
cord-001835-0s7ok4uw	3332	2	this	this	DT
cord-001835-0s7ok4uw	3332	3	structural	structural	JJ
cord-001835-0s7ok4uw	3332	4	similarity	similarity	NN
cord-001835-0s7ok4uw	3332	5	,	,	,
cord-001835-0s7ok4uw	3332	6	PSI	psi	NN
cord-001835-0s7ok4uw	3332	7	-	-	HYPH
cord-001835-0s7ok4uw	3332	8	BLAST	blast	NN
cord-001835-0s7ok4uw	3332	9	searches	search	NNS
cord-001835-0s7ok4uw	3332	10	do	do	VBP
cord-001835-0s7ok4uw	3332	11	not	not	RB
cord-001835-0s7ok4uw	3332	12	identify	identify	VB
cord-001835-0s7ok4uw	3332	13	sequence	sequence	NN
cord-001835-0s7ok4uw	3332	14	similarities	similarity	NNS
cord-001835-0s7ok4uw	3332	15	to	to	IN
cord-001835-0s7ok4uw	3332	16	known	know	VBN
cord-001835-0s7ok4uw	3332	17	TIM	TIM	NNP
cord-001835-0s7ok4uw	3332	18	-	-	HYPH
cord-001835-0s7ok4uw	3332	19	barrel	barrel	NN
cord-001835-0s7ok4uw	3332	20	proteins	protein	NNS
cord-001835-0s7ok4uw	3332	21	.	.	.
cord-001835-0s7ok4uw	3333	1	More	more	RBR
cord-001835-0s7ok4uw	3333	2	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	3333	3	profile	profile	JJ
cord-001835-0s7ok4uw	3333	4	-	-	HYPH
cord-001835-0s7ok4uw	3333	5	profile	profile	NN
cord-001835-0s7ok4uw	3333	6	searches	search	NNS
cord-001835-0s7ok4uw	3333	7	suggest	suggest	VBP
cord-001835-0s7ok4uw	3333	8	that	that	IN
cord-001835-0s7ok4uw	3333	9	the	the	DT
cord-001835-0s7ok4uw	3333	10	design	design	NN
cord-001835-0s7ok4uw	3333	11	is	be	VBZ
cord-001835-0s7ok4uw	3333	12	sufficiently	sufficiently	RB
cord-001835-0s7ok4uw	3333	13	distant	distant	JJ
cord-001835-0s7ok4uw	3333	14	from	from	IN
cord-001835-0s7ok4uw	3333	15	other	other	JJ
cord-001835-0s7ok4uw	3333	16	native	native	JJ
cord-001835-0s7ok4uw	3333	17	TIM	TIM	NNP
cord-001835-0s7ok4uw	3333	18	-	-	HYPH
cord-001835-0s7ok4uw	3333	19	barrel	barrel	NN
cord-001835-0s7ok4uw	3333	20	superfamilies	superfamily	NNS
cord-001835-0s7ok4uw	3333	21	to	to	TO
cord-001835-0s7ok4uw	3333	22	be	be	VB
cord-001835-0s7ok4uw	3333	23	in	in	IN
cord-001835-0s7ok4uw	3333	24	a	a	DT
cord-001835-0s7ok4uw	3333	25	superfamily	superfamily	NN
cord-001835-0s7ok4uw	3333	26	of	of	IN
cord-001835-0s7ok4uw	3333	27	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3333	28	own	own	JJ
cord-001835-0s7ok4uw	3333	29	,	,	,
cord-001835-0s7ok4uw	3333	30	further	further	RB
cord-001835-0s7ok4uw	3333	31	implying	imply	VBG
cord-001835-0s7ok4uw	3333	32	that	that	IN
cord-001835-0s7ok4uw	3333	33	Nature	Nature	NNP
cord-001835-0s7ok4uw	3333	34	has	have	VBZ
cord-001835-0s7ok4uw	3333	35	only	only	RB
cord-001835-0s7ok4uw	3333	36	sampled	sample	VBN
cord-001835-0s7ok4uw	3333	37	a	a	DT
cord-001835-0s7ok4uw	3333	38	subset	subset	NN
cord-001835-0s7ok4uw	3333	39	of	of	IN
cord-001835-0s7ok4uw	3333	40	the	the	DT
cord-001835-0s7ok4uw	3333	41	sequence	sequence	NN
cord-001835-0s7ok4uw	3333	42	space	space	NN
cord-001835-0s7ok4uw	3333	43	available	available	JJ
cord-001835-0s7ok4uw	3333	44	to	to	IN
cord-001835-0s7ok4uw	3333	45	the	the	DT
cord-001835-0s7ok4uw	3333	46	TIM	TIM	NNP
cord-001835-0s7ok4uw	3333	47	-	-	HYPH
cord-001835-0s7ok4uw	3333	48	barrel	barrel	NN
cord-001835-0s7ok4uw	3333	49	fold	fold	NN
cord-001835-0s7ok4uw	3333	50	.	.	.
cord-001835-0s7ok4uw	3334	1	The	the	DT
cord-001835-0s7ok4uw	3334	2	ability	ability	NN
cord-001835-0s7ok4uw	3334	3	to	to	TO
cord-001835-0s7ok4uw	3334	4	de	de	NNP
cord-001835-0s7ok4uw	3334	5	novo	novo	NNP
cord-001835-0s7ok4uw	3334	6	design	design	NN
cord-001835-0s7ok4uw	3334	7	TIM	TIM	NNP
cord-001835-0s7ok4uw	3334	8	-	-	HYPH
cord-001835-0s7ok4uw	3334	9	barrels	barrel	NNS
cord-001835-0s7ok4uw	3334	10	opens	open	VBZ
cord-001835-0s7ok4uw	3334	11	new	new	JJ
cord-001835-0s7ok4uw	3334	12	possibilities	possibility	NNS
cord-001835-0s7ok4uw	3334	13	for	for	IN
cord-001835-0s7ok4uw	3334	14	custom	custom	NN
cord-001835-0s7ok4uw	3334	15	-	-	HYPH
cord-001835-0s7ok4uw	3334	16	made	make	VBN
cord-001835-0s7ok4uw	3334	17	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3334	18	.	.	.
cord-001835-0s7ok4uw	3335	1	3	3	CD
cord-001835-0s7ok4uw	3335	2	University	University	NNP
cord-001835-0s7ok4uw	3335	3	of	of	IN
cord-001835-0s7ok4uw	3335	4	Texas	Texas	NNP
cord-001835-0s7ok4uw	3335	5	Southwestern	Southwestern	NNP
cord-001835-0s7ok4uw	3335	6	Medical	Medical	NNP
cord-001835-0s7ok4uw	3335	7	Center	Center	NNP
cord-001835-0s7ok4uw	3335	8	,	,	,
cord-001835-0s7ok4uw	3335	9	4	4	CD
cord-001835-0s7ok4uw	3335	10	BioFrontiers	BioFrontiers	NNP
cord-001835-0s7ok4uw	3335	11	Institute	Institute	NNP
cord-001835-0s7ok4uw	3335	12	,	,	,
cord-001835-0s7ok4uw	3335	13	University	University	NNP
cord-001835-0s7ok4uw	3335	14	of	of	IN
cord-001835-0s7ok4uw	3335	15	Colorado	Colorado	NNP
cord-001835-0s7ok4uw	3335	16	Creation	Creation	NNP
cord-001835-0s7ok4uw	3335	17	of	of	IN
cord-001835-0s7ok4uw	3335	18	new	new	JJ
cord-001835-0s7ok4uw	3335	19	molecular	molecular	JJ
cord-001835-0s7ok4uw	3335	20	sensors	sensor	NNS
cord-001835-0s7ok4uw	3335	21	and	and	CC
cord-001835-0s7ok4uw	3335	22	actuators	actuator	NNS
cord-001835-0s7ok4uw	3335	23	based	base	VBN
cord-001835-0s7ok4uw	3335	24	on	on	IN
cord-001835-0s7ok4uw	3335	25	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	3335	26	proteins	protein	NNS
cord-001835-0s7ok4uw	3335	27	relies	rely	VBZ
cord-001835-0s7ok4uw	3335	28	on	on	IN
cord-001835-0s7ok4uw	3335	29	methods	method	NNS
cord-001835-0s7ok4uw	3335	30	for	for	IN
cord-001835-0s7ok4uw	3335	31	identifying	identify	VBG
cord-001835-0s7ok4uw	3335	32	complex	complex	JJ
cord-001835-0s7ok4uw	3335	33	photophysical	photophysical	JJ
cord-001835-0s7ok4uw	3335	34	phenotypes	phenotype	NNS
cord-001835-0s7ok4uw	3335	35	and	and	CC
cord-001835-0s7ok4uw	3335	36	subsequently	subsequently	RB
cord-001835-0s7ok4uw	3335	37	performing	perform	VBG
cord-001835-0s7ok4uw	3335	38	separations	separation	NNS
cord-001835-0s7ok4uw	3335	39	on	on	IN
cord-001835-0s7ok4uw	3335	40	cell	cell	NN
cord-001835-0s7ok4uw	3335	41	populations	population	NNS
cord-001835-0s7ok4uw	3335	42	.	.	.
cord-001835-0s7ok4uw	3336	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3336	2	developed	develop	VBD
cord-001835-0s7ok4uw	3336	3	a	a	DT
cord-001835-0s7ok4uw	3336	4	microfluidic	microfluidic	JJ
cord-001835-0s7ok4uw	3336	5	flow	flow	NN
cord-001835-0s7ok4uw	3336	6	cytometry	cytometry	NN
cord-001835-0s7ok4uw	3336	7	approach	approach	NN
cord-001835-0s7ok4uw	3336	8	tailored	tailor	VBN
cord-001835-0s7ok4uw	3336	9	to	to	IN
cord-001835-0s7ok4uw	3336	10	interrogating	interrogate	VBG
cord-001835-0s7ok4uw	3336	11	the	the	DT
cord-001835-0s7ok4uw	3336	12	performance	performance	NN
cord-001835-0s7ok4uw	3336	13	of	of	IN
cord-001835-0s7ok4uw	3336	14	genetically	genetically	RB
cord-001835-0s7ok4uw	3336	15	-	-	HYPH
cord-001835-0s7ok4uw	3336	16	encoded	encode	VBN
cord-001835-0s7ok4uw	3336	17	fluorophores	fluorophore	NNS
cord-001835-0s7ok4uw	3336	18	and	and	CC
cord-001835-0s7ok4uw	3336	19	present	present	VBP
cord-001835-0s7ok4uw	3336	20	the	the	DT
cord-001835-0s7ok4uw	3336	21	results	result	NNS
cord-001835-0s7ok4uw	3336	22	of	of	IN
cord-001835-0s7ok4uw	3336	23	studies	study	NNS
cord-001835-0s7ok4uw	3336	24	employing	employ	VBG
cord-001835-0s7ok4uw	3336	25	this	this	DT
cord-001835-0s7ok4uw	3336	26	technology	technology	NN
cord-001835-0s7ok4uw	3336	27	.	.	.
cord-001835-0s7ok4uw	3337	1	The	the	DT
cord-001835-0s7ok4uw	3337	2	system	system	NN
cord-001835-0s7ok4uw	3337	3	screens	screen	VBZ
cord-001835-0s7ok4uw	3337	4	cell	cell	NN
cord-001835-0s7ok4uw	3337	5	-	-	HYPH
cord-001835-0s7ok4uw	3337	6	based	base	VBN
cord-001835-0s7ok4uw	3337	7	libraries	library	NNS
cord-001835-0s7ok4uw	3337	8	on	on	IN
cord-001835-0s7ok4uw	3337	9	the	the	DT
cord-001835-0s7ok4uw	3337	10	basis	basis	NN
cord-001835-0s7ok4uw	3337	11	of	of	IN
cord-001835-0s7ok4uw	3337	12	multiple	multiple	JJ
cord-001835-0s7ok4uw	3337	13	photophysical	photophysical	JJ
cord-001835-0s7ok4uw	3337	14	parameters	parameter	NNS
cord-001835-0s7ok4uw	3337	15	relevant	relevant	JJ
cord-001835-0s7ok4uw	3337	16	to	to	IN
cord-001835-0s7ok4uw	3337	17	imaging	imaging	NN
cord-001835-0s7ok4uw	3337	18	,	,	,
cord-001835-0s7ok4uw	3337	19	including	include	VBG
cord-001835-0s7ok4uw	3337	20	brightness	brightness	NN
cord-001835-0s7ok4uw	3337	21	,	,	,
cord-001835-0s7ok4uw	3337	22	photostability	photostability	NN
cord-001835-0s7ok4uw	3337	23	,	,	,
cord-001835-0s7ok4uw	3337	24	and	and	CC
cord-001835-0s7ok4uw	3337	25	excited	excited	JJ
cord-001835-0s7ok4uw	3337	26	-	-	HYPH
cord-001835-0s7ok4uw	3337	27	state	state	NN
cord-001835-0s7ok4uw	3337	28	lifetime	lifetime	NN
cord-001835-0s7ok4uw	3337	29	(	(	-LRB-
cord-001835-0s7ok4uw	3337	30	i.e.	i.e.	FW
cord-001835-0s7ok4uw	3337	31	a	a	DT
cord-001835-0s7ok4uw	3337	32	proxy	proxy	NN
cord-001835-0s7ok4uw	3337	33	for	for	IN
cord-001835-0s7ok4uw	3337	34	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3337	35	quantum	quantum	NN
cord-001835-0s7ok4uw	3337	36	yield	yield	NN
cord-001835-0s7ok4uw	3337	37	)	)	-RRB-
cord-001835-0s7ok4uw	3337	38	at	at	IN
cord-001835-0s7ok4uw	3337	39	a	a	DT
cord-001835-0s7ok4uw	3337	40	rate	rate	NN
cord-001835-0s7ok4uw	3337	41	of	of	IN
cord-001835-0s7ok4uw	3337	42	up	up	IN
cord-001835-0s7ok4uw	3337	43	to	to	TO
cord-001835-0s7ok4uw	3337	44	180	180	CD
cord-001835-0s7ok4uw	3337	45	cells	cell	NNS
cord-001835-0s7ok4uw	3337	46	/	/	SYM
cord-001835-0s7ok4uw	3337	47	sec	sec	NNP
cord-001835-0s7ok4uw	3337	48	.	.	.
cord-001835-0s7ok4uw	3338	1	In	in	IN
cord-001835-0s7ok4uw	3338	2	a	a	DT
cord-001835-0s7ok4uw	3338	3	first	first	JJ
cord-001835-0s7ok4uw	3338	4	generation	generation	NN
cord-001835-0s7ok4uw	3338	5	of	of	IN
cord-001835-0s7ok4uw	3338	6	experiments	experiment	NNS
cord-001835-0s7ok4uw	3338	7	,	,	,
cord-001835-0s7ok4uw	3338	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	3338	9	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3338	10	-	-	HYPH
cord-001835-0s7ok4uw	3338	11	guided	guide	VBN
cord-001835-0s7ok4uw	3338	12	design	design	NN
cord-001835-0s7ok4uw	3338	13	was	be	VBD
cord-001835-0s7ok4uw	3338	14	used	use	VBN
cord-001835-0s7ok4uw	3338	15	to	to	TO
cord-001835-0s7ok4uw	3338	16	create	create	VB
cord-001835-0s7ok4uw	3338	17	a	a	DT
cord-001835-0s7ok4uw	3338	18	library	library	NN
cord-001835-0s7ok4uw	3338	19	of	of	IN
cord-001835-0s7ok4uw	3338	20	mCherry	mCherry	NNP
cord-001835-0s7ok4uw	3338	21	mutants	mutant	NNS
cord-001835-0s7ok4uw	3338	22	that	that	WDT
cord-001835-0s7ok4uw	3338	23	was	be	VBD
cord-001835-0s7ok4uw	3338	24	screened	screen	VBN
cord-001835-0s7ok4uw	3338	25	with	with	IN
cord-001835-0s7ok4uw	3338	26	this	this	DT
cord-001835-0s7ok4uw	3338	27	system	system	NN
cord-001835-0s7ok4uw	3338	28	,	,	,
cord-001835-0s7ok4uw	3338	29	resulting	result	VBG
cord-001835-0s7ok4uw	3338	30	in	in	IN
cord-001835-0s7ok4uw	3338	31	the	the	DT
cord-001835-0s7ok4uw	3338	32	identification	identification	NN
cord-001835-0s7ok4uw	3338	33	of	of	IN
cord-001835-0s7ok4uw	3338	34	a	a	DT
cord-001835-0s7ok4uw	3338	35	variant	variant	NN
cord-001835-0s7ok4uw	3338	36	with	with	IN
cord-001835-0s7ok4uw	3338	37	a	a	DT
cord-001835-0s7ok4uw	3338	38	higher	high	JJR
cord-001835-0s7ok4uw	3338	39	stability	stability	NN
cord-001835-0s7ok4uw	3338	40	b	b	NN
cord-001835-0s7ok4uw	3338	41	-	-	HYPH
cord-001835-0s7ok4uw	3338	42	barrel	barrel	NN
cord-001835-0s7ok4uw	3338	43	and	and	CC
cord-001835-0s7ok4uw	3338	44	improved	improve	VBN
cord-001835-0s7ok4uw	3338	45	photostability	photostability	NN
cord-001835-0s7ok4uw	3338	46	but	but	CC
cord-001835-0s7ok4uw	3338	47	with	with	IN
cord-001835-0s7ok4uw	3338	48	a	a	DT
cord-001835-0s7ok4uw	3338	49	decreased	decrease	VBN
cord-001835-0s7ok4uw	3338	50	brightness	brightness	NN
cord-001835-0s7ok4uw	3338	51	due	due	IN
cord-001835-0s7ok4uw	3338	52	to	to	IN
cord-001835-0s7ok4uw	3338	53	reduction	reduction	NN
cord-001835-0s7ok4uw	3338	54	in	in	IN
cord-001835-0s7ok4uw	3338	55	the	the	DT
cord-001835-0s7ok4uw	3338	56	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3338	57	quantum	quantum	NN
cord-001835-0s7ok4uw	3338	58	yield	yield	NN
cord-001835-0s7ok4uw	3338	59	.	.	.
cord-001835-0s7ok4uw	3339	1	To	to	TO
cord-001835-0s7ok4uw	3339	2	avoid	avoid	VB
cord-001835-0s7ok4uw	3339	3	inadvertent	inadvertent	JJ
cord-001835-0s7ok4uw	3339	4	decreases	decrease	NNS
cord-001835-0s7ok4uw	3339	5	in	in	IN
cord-001835-0s7ok4uw	3339	6	this	this	DT
cord-001835-0s7ok4uw	3339	7	important	important	JJ
cord-001835-0s7ok4uw	3339	8	performance	performance	NN
cord-001835-0s7ok4uw	3339	9	criterion	criterion	NN
cord-001835-0s7ok4uw	3339	10	,	,	,
cord-001835-0s7ok4uw	3339	11	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	3339	12	rounds	round	NNS
cord-001835-0s7ok4uw	3339	13	of	of	IN
cord-001835-0s7ok4uw	3339	14	selection	selection	NN
cord-001835-0s7ok4uw	3339	15	were	be	VBD
cord-001835-0s7ok4uw	3339	16	performed	perform	VBN
cord-001835-0s7ok4uw	3339	17	on	on	IN
cord-001835-0s7ok4uw	3339	18	the	the	DT
cord-001835-0s7ok4uw	3339	19	basis	basis	NN
cord-001835-0s7ok4uw	3339	20	of	of	IN
cord-001835-0s7ok4uw	3339	21	both	both	CC
cord-001835-0s7ok4uw	3339	22	photostability	photostability	NN
cord-001835-0s7ok4uw	3339	23	and	and	CC
cord-001835-0s7ok4uw	3339	24	excited	excited	JJ
cord-001835-0s7ok4uw	3339	25	-	-	HYPH
cord-001835-0s7ok4uw	3339	26	state	state	NN
cord-001835-0s7ok4uw	3339	27	lifetime	lifetime	NN
cord-001835-0s7ok4uw	3339	28	as	as	IN
cord-001835-0s7ok4uw	3339	29	sorting	sort	VBG
cord-001835-0s7ok4uw	3339	30	criteria	criterion	NNS
cord-001835-0s7ok4uw	3339	31	.	.	.
cord-001835-0s7ok4uw	3340	1	In	in	IN
cord-001835-0s7ok4uw	3340	2	these	these	DT
cord-001835-0s7ok4uw	3340	3	second	second	JJ
cord-001835-0s7ok4uw	3340	4	generation	generation	NN
cord-001835-0s7ok4uw	3340	5	selections	selection	NNS
cord-001835-0s7ok4uw	3340	6	,	,	,
cord-001835-0s7ok4uw	3340	7	mutations	mutation	NNS
cord-001835-0s7ok4uw	3340	8	were	be	VBD
cord-001835-0s7ok4uw	3340	9	designed	design	VBN
cord-001835-0s7ok4uw	3340	10	to	to	TO
cord-001835-0s7ok4uw	3340	11	target	target	VB
cord-001835-0s7ok4uw	3340	12	pathways	pathway	NNS
cord-001835-0s7ok4uw	3340	13	of	of	IN
cord-001835-0s7ok4uw	3340	14	oxygen	oxygen	NN
cord-001835-0s7ok4uw	3340	15	access	access	NN
cord-001835-0s7ok4uw	3340	16	through	through	IN
cord-001835-0s7ok4uw	3340	17	the	the	DT
cord-001835-0s7ok4uw	3340	18	bottom	bottom	NN
cord-001835-0s7ok4uw	3340	19	of	of	IN
cord-001835-0s7ok4uw	3340	20	the	the	DT
cord-001835-0s7ok4uw	3340	21	bbarrel	bbarrel	NN
cord-001835-0s7ok4uw	3340	22	in	in	IN
cord-001835-0s7ok4uw	3340	23	addition	addition	NN
cord-001835-0s7ok4uw	3340	24	to	to	IN
cord-001835-0s7ok4uw	3340	25	a	a	DT
cord-001835-0s7ok4uw	3340	26	position	position	NN
cord-001835-0s7ok4uw	3340	27	that	that	WDT
cord-001835-0s7ok4uw	3340	28	directly	directly	RB
cord-001835-0s7ok4uw	3340	29	interacts	interact	VBZ
cord-001835-0s7ok4uw	3340	30	with	with	IN
cord-001835-0s7ok4uw	3340	31	the	the	DT
cord-001835-0s7ok4uw	3340	32	chromophore	chromophore	NN
cord-001835-0s7ok4uw	3340	33	.	.	.
cord-001835-0s7ok4uw	3341	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	3341	2	,	,	,
cord-001835-0s7ok4uw	3341	3	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	3341	4	rounds	round	NNS
cord-001835-0s7ok4uw	3341	5	of	of	IN
cord-001835-0s7ok4uw	3341	6	screening	screening	NN
cord-001835-0s7ok4uw	3341	7	were	be	VBD
cord-001835-0s7ok4uw	3341	8	used	use	VBN
cord-001835-0s7ok4uw	3341	9	to	to	TO
cord-001835-0s7ok4uw	3341	10	improve	improve	VB
cord-001835-0s7ok4uw	3341	11	folding	folding	NN
cord-001835-0s7ok4uw	3341	12	and	and	CC
cord-001835-0s7ok4uw	3341	13	maturation	maturation	NN
cord-001835-0s7ok4uw	3341	14	.	.	.
cord-001835-0s7ok4uw	3342	1	The	the	DT
cord-001835-0s7ok4uw	3342	2	multiparameter	multiparameter	NN
cord-001835-0s7ok4uw	3342	3	sort	sort	RB
cord-001835-0s7ok4uw	3342	4	identified	identify	VBD
cord-001835-0s7ok4uw	3342	5	multiple	multiple	JJ
cord-001835-0s7ok4uw	3342	6	clones	clone	NNS
cord-001835-0s7ok4uw	3342	7	with	with	IN
cord-001835-0s7ok4uw	3342	8	up	up	IN
cord-001835-0s7ok4uw	3342	9	to	to	TO
cord-001835-0s7ok4uw	3342	10	8-fold	8-fold	CD
cord-001835-0s7ok4uw	3342	11	improved	improve	VBN
cord-001835-0s7ok4uw	3342	12	photostability	photostability	NN
cord-001835-0s7ok4uw	3342	13	and	and	CC
cord-001835-0s7ok4uw	3342	14	up	up	IN
cord-001835-0s7ok4uw	3342	15	to	to	TO
cord-001835-0s7ok4uw	3342	16	double	double	VB
cord-001835-0s7ok4uw	3342	17	the	the	DT
cord-001835-0s7ok4uw	3342	18	excited	excited	JJ
cord-001835-0s7ok4uw	3342	19	-	-	HYPH
cord-001835-0s7ok4uw	3342	20	state	state	NN
cord-001835-0s7ok4uw	3342	21	lifetime	lifetime	NN
cord-001835-0s7ok4uw	3342	22	of	of	IN
cord-001835-0s7ok4uw	3342	23	the	the	DT
cord-001835-0s7ok4uw	3342	24	parent	parent	NN
cord-001835-0s7ok4uw	3342	25	mCherry	mCherry	NNP
cord-001835-0s7ok4uw	3342	26	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	3342	27	protein	protein	NN
cord-001835-0s7ok4uw	3342	28	.	.	.
cord-001835-0s7ok4uw	3343	1	The	the	DT
cord-001835-0s7ok4uw	3343	2	best	good	JJS
cord-001835-0s7ok4uw	3343	3	mutant	mutant	NN
cord-001835-0s7ok4uw	3343	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3343	5	identified	identify	VBD
cord-001835-0s7ok4uw	3343	6	produces	produce	VBZ
cord-001835-0s7ok4uw	3343	7	one	one	CD
cord-001835-0s7ok4uw	3343	8	order	order	NN
cord-001835-0s7ok4uw	3343	9	of	of	IN
cord-001835-0s7ok4uw	3343	10	magnitude	magnitude	NN
cord-001835-0s7ok4uw	3343	11	more	more	JJR
cord-001835-0s7ok4uw	3343	12	photons	photon	NNS
cord-001835-0s7ok4uw	3343	13	before	before	IN
cord-001835-0s7ok4uw	3343	14	photobleaching	photobleache	VBG
cord-001835-0s7ok4uw	3343	15	compared	compare	VBN
cord-001835-0s7ok4uw	3343	16	to	to	IN
cord-001835-0s7ok4uw	3343	17	mCherry	mCherry	NNP
cord-001835-0s7ok4uw	3343	18	,	,	,
cord-001835-0s7ok4uw	3343	19	at	at	IN
cord-001835-0s7ok4uw	3343	20	excitation	excitation	NN
cord-001835-0s7ok4uw	3343	21	conditions	condition	NNS
cord-001835-0s7ok4uw	3343	22	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	3343	23	of	of	IN
cord-001835-0s7ok4uw	3343	24	confocal	confocal	JJ
cord-001835-0s7ok4uw	3343	25	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3343	26	microscopy	microscopy	NN
cord-001835-0s7ok4uw	3343	27	.	.	.
cord-001835-0s7ok4uw	3344	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3344	2	results	result	NNS
cord-001835-0s7ok4uw	3344	3	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	3344	4	the	the	DT
cord-001835-0s7ok4uw	3344	5	utility	utility	NN
cord-001835-0s7ok4uw	3344	6	of	of	IN
cord-001835-0s7ok4uw	3344	7	combining	combine	VBG
cord-001835-0s7ok4uw	3344	8	moleculardynamics	moleculardynamics	NNP
cord-001835-0s7ok4uw	3344	9	-	-	HYPH
cord-001835-0s7ok4uw	3344	10	guided	guide	VBN
cord-001835-0s7ok4uw	3344	11	library	library	NN
cord-001835-0s7ok4uw	3344	12	design	design	NN
cord-001835-0s7ok4uw	3344	13	with	with	IN
cord-001835-0s7ok4uw	3344	14	technology	technology	NN
cord-001835-0s7ok4uw	3344	15	for	for	IN
cord-001835-0s7ok4uw	3344	16	photophysics	photophysic	NNS
cord-001835-0s7ok4uw	3344	17	-	-	HYPH
cord-001835-0s7ok4uw	3344	18	based	base	VBN
cord-001835-0s7ok4uw	3344	19	selections	selection	NNS
cord-001835-0s7ok4uw	3344	20	.	.	.
cord-001835-0s7ok4uw	3345	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3345	2	anticipate	anticipate	VBP
cord-001835-0s7ok4uw	3345	3	that	that	IN
cord-001835-0s7ok4uw	3345	4	the	the	DT
cord-001835-0s7ok4uw	3345	5	new	new	JJ
cord-001835-0s7ok4uw	3345	6	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	3345	7	proteins	protein	NNS
cord-001835-0s7ok4uw	3345	8	obtained	obtain	VBN
cord-001835-0s7ok4uw	3345	9	in	in	IN
cord-001835-0s7ok4uw	3345	10	this	this	DT
cord-001835-0s7ok4uw	3345	11	work	work	NN
cord-001835-0s7ok4uw	3345	12	will	will	MD
cord-001835-0s7ok4uw	3345	13	find	find	VB
cord-001835-0s7ok4uw	3345	14	use	use	NN
cord-001835-0s7ok4uw	3345	15	in	in	IN
cord-001835-0s7ok4uw	3345	16	low	low	JJ
cord-001835-0s7ok4uw	3345	17	-	-	HYPH
cord-001835-0s7ok4uw	3345	18	copy	copy	NN
cord-001835-0s7ok4uw	3345	19	-	-	HYPH
cord-001835-0s7ok4uw	3345	20	number	number	NN
cord-001835-0s7ok4uw	3345	21	and	and	CC
cord-001835-0s7ok4uw	3345	22	long	long	JJ
cord-001835-0s7ok4uw	3345	23	-	-	HYPH
cord-001835-0s7ok4uw	3345	24	duration	duration	NN
cord-001835-0s7ok4uw	3345	25	imaging	imaging	NN
cord-001835-0s7ok4uw	3345	26	live	live	JJ
cord-001835-0s7ok4uw	3345	27	cell	cell	NN
cord-001835-0s7ok4uw	3345	28	imaging	imaging	NN
cord-001835-0s7ok4uw	3345	29	applications	application	NNS
cord-001835-0s7ok4uw	3345	30	in	in	IN
cord-001835-0s7ok4uw	3345	31	cell	cell	NN
cord-001835-0s7ok4uw	3345	32	-	-	HYPH
cord-001835-0s7ok4uw	3345	33	lines	line	NNS
cord-001835-0s7ok4uw	3345	34	created	create	VBN
cord-001835-0s7ok4uw	3345	35	by	by	IN
cord-001835-0s7ok4uw	3345	36	genomic	genomic	JJ
cord-001835-0s7ok4uw	3345	37	editing	editing	NN
cord-001835-0s7ok4uw	3345	38	techniques	technique	NNS
cord-001835-0s7ok4uw	3345	39	.	.	.
cord-001835-0s7ok4uw	3346	1	Targeted	target	VBN
cord-001835-0s7ok4uw	3346	2	protein	protein	NN
cord-001835-0s7ok4uw	3346	3	degradation	degradation	NN
cord-001835-0s7ok4uw	3346	4	achieved	achieve	VBN
cord-001835-0s7ok4uw	3346	5	through	through	IN
cord-001835-0s7ok4uw	3346	6	a	a	DT
cord-001835-0s7ok4uw	3346	7	combination	combination	NN
cord-001835-0s7ok4uw	3346	8	of	of	IN
cord-001835-0s7ok4uw	3346	9	degrons	degron	NNS
cord-001835-0s7ok4uw	3346	10	from	from	IN
cord-001835-0s7ok4uw	3346	11	yeast	yeast	NN
cord-001835-0s7ok4uw	3346	12	and	and	CC
cord-001835-0s7ok4uw	3346	13	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	3346	14	ornithine	ornithine	NN
cord-001835-0s7ok4uw	3346	15	decarboxylase	decarboxylase	NN
cord-001835-0s7ok4uw	3346	16	Rushikesh	Rushikesh	NNP
cord-001835-0s7ok4uw	3346	17	Joshi	Joshi	NNP
cord-001835-0s7ok4uw	3346	18	1	1	CD
cord-001835-0s7ok4uw	3346	19	,	,	,
cord-001835-0s7ok4uw	3346	20	Ratna	Ratna	NNP
cord-001835-0s7ok4uw	3346	21	Prabha	Prabha	NNP
cord-001835-0s7ok4uw	3346	22	C.	C.	NNP
cord-001835-0s7ok4uw	3346	23	1	1	CD
cord-001835-0s7ok4uw	3346	24	1	1	CD
cord-001835-0s7ok4uw	3347	1	The	the	DT
cord-001835-0s7ok4uw	3347	2	Maharaja	Maharaja	NNP
cord-001835-0s7ok4uw	3347	3	Sayajirao	Sayajirao	NNP
cord-001835-0s7ok4uw	3347	4	University	University	NNP
cord-001835-0s7ok4uw	3347	5	of	of	IN
cord-001835-0s7ok4uw	3347	6	Baroda	Baroda	NNP
cord-001835-0s7ok4uw	3347	7	Targeted	Targeted	NNP
cord-001835-0s7ok4uw	3347	8	protein	protein	NN
cord-001835-0s7ok4uw	3347	9	degradation	degradation	NN
cord-001835-0s7ok4uw	3347	10	achieved	achieve	VBN
cord-001835-0s7ok4uw	3347	11	through	through	IN
cord-001835-0s7ok4uw	3347	12	a	a	DT
cord-001835-0s7ok4uw	3347	13	combination	combination	NN
cord-001835-0s7ok4uw	3347	14	of	of	IN
cord-001835-0s7ok4uw	3347	15	degrons	degron	NNS
cord-001835-0s7ok4uw	3347	16	from	from	IN
cord-001835-0s7ok4uw	3347	17	yeast	yeast	NN
cord-001835-0s7ok4uw	3347	18	and	and	CC
cord-001835-0s7ok4uw	3347	19	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	3347	20	ornithine	ornithine	NN
cord-001835-0s7ok4uw	3347	21	decarboxylase	decarboxylase	NN
cord-001835-0s7ok4uw	3347	22	Targeting	target	VBG
cord-001835-0s7ok4uw	3347	23	the	the	DT
cord-001835-0s7ok4uw	3347	24	over	over	JJ
cord-001835-0s7ok4uw	3347	25	accumulated	accumulate	VBN
cord-001835-0s7ok4uw	3347	26	protein	protein	NN
cord-001835-0s7ok4uw	3347	27	in	in	IN
cord-001835-0s7ok4uw	3347	28	the	the	DT
cord-001835-0s7ok4uw	3347	29	cell	cell	NN
cord-001835-0s7ok4uw	3347	30	for	for	IN
cord-001835-0s7ok4uw	3347	31	degradation	degradation	NN
cord-001835-0s7ok4uw	3347	32	using	use	VBG
cord-001835-0s7ok4uw	3347	33	specific	specific	JJ
cord-001835-0s7ok4uw	3347	34	degrons	degron	NNS
cord-001835-0s7ok4uw	3347	35	is	be	VBZ
cord-001835-0s7ok4uw	3347	36	an	an	DT
cord-001835-0s7ok4uw	3347	37	emerging	emerge	VBG
cord-001835-0s7ok4uw	3347	38	research	research	NN
cord-001835-0s7ok4uw	3347	39	area	area	NN
cord-001835-0s7ok4uw	3347	40	.	.	.
cord-001835-0s7ok4uw	3348	1	The	the	DT
cord-001835-0s7ok4uw	3348	2	degradation	degradation	NN
cord-001835-0s7ok4uw	3348	3	of	of	IN
cord-001835-0s7ok4uw	3348	4	the	the	DT
cord-001835-0s7ok4uw	3348	5	vast	vast	JJ
cord-001835-0s7ok4uw	3348	6	majority	majority	NN
cord-001835-0s7ok4uw	3348	7	of	of	IN
cord-001835-0s7ok4uw	3348	8	cellular	cellular	JJ
cord-001835-0s7ok4uw	3348	9	proteins	protein	NNS
cord-001835-0s7ok4uw	3348	10	is	be	VBZ
cord-001835-0s7ok4uw	3348	11	targeted	target	VBN
cord-001835-0s7ok4uw	3348	12	by	by	IN
cord-001835-0s7ok4uw	3348	13	the	the	DT
cord-001835-0s7ok4uw	3348	14	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	3348	15	-	-	HYPH
cord-001835-0s7ok4uw	3348	16	proteasome	proteasome	VBN
cord-001835-0s7ok4uw	3348	17	pathway	pathway	NN
cord-001835-0s7ok4uw	3348	18	.	.	.
cord-001835-0s7ok4uw	3349	1	But	but	CC
cord-001835-0s7ok4uw	3349	2	in	in	IN
cord-001835-0s7ok4uw	3349	3	the	the	DT
cord-001835-0s7ok4uw	3349	4	case	case	NN
cord-001835-0s7ok4uw	3349	5	of	of	IN
cord-001835-0s7ok4uw	3349	6	ubiquitin	ubiquitin	JJ
cord-001835-0s7ok4uw	3349	7	independent	independent	JJ
cord-001835-0s7ok4uw	3349	8	protein	protein	NN
cord-001835-0s7ok4uw	3349	9	degradation	degradation	NN
cord-001835-0s7ok4uw	3349	10	,	,	,
cord-001835-0s7ok4uw	3349	11	ODC	ODC	NNP
cord-001835-0s7ok4uw	3349	12	/	/	SYM
cord-001835-0s7ok4uw	3349	13	AZ	AZ	NNP
cord-001835-0s7ok4uw	3349	14	system	system	NN
cord-001835-0s7ok4uw	3349	15	is	be	VBZ
cord-001835-0s7ok4uw	3349	16	more	more	RBR
cord-001835-0s7ok4uw	3349	17	effective	effective	JJ
cord-001835-0s7ok4uw	3349	18	in	in	IN
cord-001835-0s7ok4uw	3349	19	achieving	achieve	VBG
cord-001835-0s7ok4uw	3349	20	targeted	target	VBN
cord-001835-0s7ok4uw	3349	21	protein	protein	NN
cord-001835-0s7ok4uw	3349	22	degradation	degradation	NN
cord-001835-0s7ok4uw	3349	23	than	than	IN
cord-001835-0s7ok4uw	3349	24	other	other	JJ
cord-001835-0s7ok4uw	3349	25	types	type	NNS
cord-001835-0s7ok4uw	3349	26	of	of	IN
cord-001835-0s7ok4uw	3349	27	degradation	degradation	NN
cord-001835-0s7ok4uw	3349	28	1	1	CD
cord-001835-0s7ok4uw	3349	29	.	.	.
cord-001835-0s7ok4uw	3350	1	Ornithine	ornithine	JJ
cord-001835-0s7ok4uw	3350	2	decarboxylase	decarboxylase	NN
cord-001835-0s7ok4uw	3350	3	(	(	-LRB-
cord-001835-0s7ok4uw	3350	4	ODC	ODC	NNP
cord-001835-0s7ok4uw	3350	5	)	)	-RRB-
cord-001835-0s7ok4uw	3350	6	is	be	VBZ
cord-001835-0s7ok4uw	3350	7	key	key	JJ
cord-001835-0s7ok4uw	3350	8	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	3350	9	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3350	10	in	in	IN
cord-001835-0s7ok4uw	3350	11	the	the	DT
cord-001835-0s7ok4uw	3350	12	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	3350	13	of	of	IN
cord-001835-0s7ok4uw	3350	14	polyamines	polyamine	NNS
cord-001835-0s7ok4uw	3350	15	.	.	.
cord-001835-0s7ok4uw	3351	1	The	the	DT
cord-001835-0s7ok4uw	3351	2	protein	protein	NN
cord-001835-0s7ok4uw	3351	3	has	have	VBZ
cord-001835-0s7ok4uw	3351	4	two	two	CD
cord-001835-0s7ok4uw	3351	5	domains	domain	NNS
cord-001835-0s7ok4uw	3351	6	namely	namely	RB
cord-001835-0s7ok4uw	3351	7	,	,	,
cord-001835-0s7ok4uw	3351	8	N	n	CD
cord-001835-0s7ok4uw	3351	9	terminal	terminal	NN
cord-001835-0s7ok4uw	3351	10	a	a	NN
cord-001835-0s7ok4uw	3351	11	/	/	SYM
cord-001835-0s7ok4uw	3351	12	b	b	NN
cord-001835-0s7ok4uw	3351	13	barrel	barrel	NN
cord-001835-0s7ok4uw	3351	14	domain	domain	NN
cord-001835-0s7ok4uw	3351	15	and	and	CC
cord-001835-0s7ok4uw	3351	16	C	c	NN
cord-001835-0s7ok4uw	3351	17	-	-	HYPH
cord-001835-0s7ok4uw	3351	18	terminal	terminal	NN
cord-001835-0s7ok4uw	3351	19	b	b	NN
cord-001835-0s7ok4uw	3351	20	-	-	HYPH
cord-001835-0s7ok4uw	3351	21	sheet	sheet	NN
cord-001835-0s7ok4uw	3351	22	domain	domain	NN
cord-001835-0s7ok4uw	3351	23	.	.	.
cord-001835-0s7ok4uw	3352	1	Degradation	degradation	NN
cord-001835-0s7ok4uw	3352	2	of	of	IN
cord-001835-0s7ok4uw	3352	3	ODC	ODC	NNP
cord-001835-0s7ok4uw	3352	4	is	be	VBZ
cord-001835-0s7ok4uw	3352	5	mediated	mediate	VBN
cord-001835-0s7ok4uw	3352	6	by	by	IN
cord-001835-0s7ok4uw	3352	7	polyamine	polyamine	NN
cord-001835-0s7ok4uw	3352	8	inducible	inducible	JJ
cord-001835-0s7ok4uw	3352	9	protein	protein	NN
cord-001835-0s7ok4uw	3352	10	,	,	,
cord-001835-0s7ok4uw	3352	11	antizyme	antizyme	NNS
cord-001835-0s7ok4uw	3352	12	(	(	-LRB-
cord-001835-0s7ok4uw	3352	13	AZ	AZ	NNP
cord-001835-0s7ok4uw	3352	14	)	)	-RRB-
cord-001835-0s7ok4uw	3352	15	.	.	.
cord-001835-0s7ok4uw	3353	1	Antizyme	Antizyme	NNP
cord-001835-0s7ok4uw	3353	2	interacts	interact	VBZ
cord-001835-0s7ok4uw	3353	3	with	with	IN
cord-001835-0s7ok4uw	3353	4	ODC	ODC	NNP
cord-001835-0s7ok4uw	3353	5	on	on	IN
cord-001835-0s7ok4uw	3353	6	N	n	CD
cord-001835-0s7ok4uw	3353	7	-	-	HYPH
cord-001835-0s7ok4uw	3353	8	terminal	terminal	NN
cord-001835-0s7ok4uw	3353	9	region	region	NN
cord-001835-0s7ok4uw	3353	10	,	,	,
cord-001835-0s7ok4uw	3353	11	which	which	WDT
cord-001835-0s7ok4uw	3353	12	results	result	VBZ
cord-001835-0s7ok4uw	3353	13	in	in	IN
cord-001835-0s7ok4uw	3353	14	degradation	degradation	NN
cord-001835-0s7ok4uw	3353	15	of	of	IN
cord-001835-0s7ok4uw	3353	16	ODC	ODC	NNP
cord-001835-0s7ok4uw	3353	17	by	by	IN
cord-001835-0s7ok4uw	3353	18	proteasomes	proteasomes	NNP
cord-001835-0s7ok4uw	3353	19	.	.	.
cord-001835-0s7ok4uw	3354	1	In	in	IN
cord-001835-0s7ok4uw	3354	2	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	3354	3	ODC	ODC	NNP
cord-001835-0s7ok4uw	3354	4	the	the	DT
cord-001835-0s7ok4uw	3354	5	C	c	NN
cord-001835-0s7ok4uw	3354	6	-	-	HYPH
cord-001835-0s7ok4uw	3354	7	terminal	terminal	NN
cord-001835-0s7ok4uw	3354	8	has	have	VBZ
cord-001835-0s7ok4uw	3354	9	an	an	DT
cord-001835-0s7ok4uw	3354	10	unstructured	unstructured	JJ
cord-001835-0s7ok4uw	3354	11	tail	tail	NN
cord-001835-0s7ok4uw	3354	12	of	of	IN
cord-001835-0s7ok4uw	3354	13	37	37	CD
cord-001835-0s7ok4uw	3354	14	residues	residue	NNS
cord-001835-0s7ok4uw	3354	15	,	,	,
cord-001835-0s7ok4uw	3354	16	which	which	WDT
cord-001835-0s7ok4uw	3354	17	pulls	pull	VBZ
cord-001835-0s7ok4uw	3354	18	ODC	ODC	NNP
cord-001835-0s7ok4uw	3354	19	into	into	IN
cord-001835-0s7ok4uw	3354	20	proteasome	proteasome	NN
cord-001835-0s7ok4uw	3354	21	for	for	IN
cord-001835-0s7ok4uw	3354	22	degradation	degradation	NN
cord-001835-0s7ok4uw	3354	23	.	.	.
cord-001835-0s7ok4uw	3355	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3355	2	was	be	VBD
cord-001835-0s7ok4uw	3355	3	reported	report	VBN
cord-001835-0s7ok4uw	3355	4	earlier	early	RBR
cord-001835-0s7ok4uw	3355	5	by	by	IN
cord-001835-0s7ok4uw	3355	6	Coffino	Coffino	NNP
cord-001835-0s7ok4uw	3355	7	's	's	POS
cord-001835-0s7ok4uw	3355	8	group	group	NN
cord-001835-0s7ok4uw	3355	9	that	that	IN
cord-001835-0s7ok4uw	3355	10	the	the	DT
cord-001835-0s7ok4uw	3355	11	unstructured	unstructured	JJ
cord-001835-0s7ok4uw	3355	12	tail	tail	NN
cord-001835-0s7ok4uw	3355	13	acts	act	NNS
cord-001835-0s7ok4uw	3355	14	as	as	IN
cord-001835-0s7ok4uw	3355	15	a	a	DT
cord-001835-0s7ok4uw	3355	16	degron	degron	NN
cord-001835-0s7ok4uw	3355	17	in	in	IN
cord-001835-0s7ok4uw	3355	18	chimeric	chimeric	JJ
cord-001835-0s7ok4uw	3355	19	fusion	fusion	NN
cord-001835-0s7ok4uw	3355	20	with	with	IN
cord-001835-0s7ok4uw	3355	21	GFP	GFP	NNP
cord-001835-0s7ok4uw	3355	22	2	2	CD
cord-001835-0s7ok4uw	3355	23	.	.	.
cord-001835-0s7ok4uw	3356	1	In	in	IN
cord-001835-0s7ok4uw	3356	2	yeast	yeast	NN
cord-001835-0s7ok4uw	3356	3	,	,	,
cord-001835-0s7ok4uw	3356	4	same	same	JJ
cord-001835-0s7ok4uw	3356	5	function	function	NN
cord-001835-0s7ok4uw	3356	6	is	be	VBZ
cord-001835-0s7ok4uw	3356	7	achieved	achieve	VBN
cord-001835-0s7ok4uw	3356	8	by	by	IN
cord-001835-0s7ok4uw	3356	9	N	n	CD
cord-001835-0s7ok4uw	3356	10	-	-	HYPH
cord-001835-0s7ok4uw	3356	11	terminal	terminal	NN
cord-001835-0s7ok4uw	3356	12	44	44	CD
cord-001835-0s7ok4uw	3356	13	residues	residue	NNS
cord-001835-0s7ok4uw	3356	14	3	3	CD
cord-001835-0s7ok4uw	3356	15	.	.	.
cord-001835-0s7ok4uw	3357	1	Present	present	JJ
cord-001835-0s7ok4uw	3357	2	study	study	NN
cord-001835-0s7ok4uw	3357	3	focuses	focus	VBZ
cord-001835-0s7ok4uw	3357	4	on	on	IN
cord-001835-0s7ok4uw	3357	5	accomplishing	accomplish	VBG
cord-001835-0s7ok4uw	3357	6	targeted	target	VBN
cord-001835-0s7ok4uw	3357	7	protein	protein	NN
cord-001835-0s7ok4uw	3357	8	degradation	degradation	NN
cord-001835-0s7ok4uw	3357	9	in	in	IN
cord-001835-0s7ok4uw	3357	10	Saccharomyces	Saccharomyces	NNP
cord-001835-0s7ok4uw	3357	11	cerevisiae	cerevisiae	NNS
cord-001835-0s7ok4uw	3357	12	by	by	IN
cord-001835-0s7ok4uw	3357	13	adding	add	VBG
cord-001835-0s7ok4uw	3357	14	these	these	DT
cord-001835-0s7ok4uw	3357	15	two	two	CD
cord-001835-0s7ok4uw	3357	16	degradation	degradation	NN
cord-001835-0s7ok4uw	3357	17	signals	signal	NNS
cord-001835-0s7ok4uw	3357	18	or	or	CC
cord-001835-0s7ok4uw	3357	19	degrons	degron	NNS
cord-001835-0s7ok4uw	3357	20	of	of	IN
cord-001835-0s7ok4uw	3357	21	yeast	yeast	NN
cord-001835-0s7ok4uw	3357	22	ODC	ODC	NNP
cord-001835-0s7ok4uw	3357	23	and	and	CC
cord-001835-0s7ok4uw	3357	24	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	3357	25	ODC	ODC	NNP
cord-001835-0s7ok4uw	3357	26	as	as	IN
cord-001835-0s7ok4uw	3357	27	tags	tag	NNS
cord-001835-0s7ok4uw	3357	28	to	to	IN
cord-001835-0s7ok4uw	3357	29	a	a	DT
cord-001835-0s7ok4uw	3357	30	reporter	reporter	NN
cord-001835-0s7ok4uw	3357	31	protein	protein	NN
cord-001835-0s7ok4uw	3357	32	.	.	.
cord-001835-0s7ok4uw	3358	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3358	2	have	have	VBP
cord-001835-0s7ok4uw	3358	3	selected	select	VBN
cord-001835-0s7ok4uw	3358	4	two	two	CD
cord-001835-0s7ok4uw	3358	5	degrons	degron	NNS
cord-001835-0s7ok4uw	3358	6	namely	namely	RB
cord-001835-0s7ok4uw	3358	7	,	,	,
cord-001835-0s7ok4uw	3358	8	N	n	CD
cord-001835-0s7ok4uw	3358	9	terminal	terminal	NN
cord-001835-0s7ok4uw	3358	10	a	a	NN
cord-001835-0s7ok4uw	3358	11	/	/	SYM
cord-001835-0s7ok4uw	3358	12	b	b	NN
cord-001835-0s7ok4uw	3358	13	barrel	barrel	NN
cord-001835-0s7ok4uw	3358	14	domain	domain	NN
cord-001835-0s7ok4uw	3358	15	of	of	IN
cord-001835-0s7ok4uw	3358	16	yeast	yeast	NN
cord-001835-0s7ok4uw	3358	17	ODC	ODC	NNP
cord-001835-0s7ok4uw	3358	18	and	and	CC
cord-001835-0s7ok4uw	3358	19	C	C	NNP
cord-001835-0s7ok4uw	3358	20	-	-	HYPH
cord-001835-0s7ok4uw	3358	21	terminal	terminal	NN
cord-001835-0s7ok4uw	3358	22	37	37	CD
cord-001835-0s7ok4uw	3358	23	residues	residue	NNS
cord-001835-0s7ok4uw	3358	24	of	of	IN
cord-001835-0s7ok4uw	3358	25	mouse	mouse	NN
cord-001835-0s7ok4uw	3358	26	ODC	ODC	NNP
cord-001835-0s7ok4uw	3358	27	and	and	CC
cord-001835-0s7ok4uw	3358	28	grafted	graft	VBD
cord-001835-0s7ok4uw	3358	29	them	-PRON-	PRP
cord-001835-0s7ok4uw	3358	30	to	to	IN
cord-001835-0s7ok4uw	3358	31	N	N	NNP
cord-001835-0s7ok4uw	3358	32	and	and	CC
cord-001835-0s7ok4uw	3358	33	C	c	NN
cord-001835-0s7ok4uw	3358	34	-	-	HYPH
cord-001835-0s7ok4uw	3358	35	terminus	terminus	NN
cord-001835-0s7ok4uw	3358	36	of	of	IN
cord-001835-0s7ok4uw	3358	37	the	the	DT
cord-001835-0s7ok4uw	3358	38	reporter	reporter	NN
cord-001835-0s7ok4uw	3358	39	protein	protein	NN
cord-001835-0s7ok4uw	3358	40	yEGFP	yEGFP	NNP
cord-001835-0s7ok4uw	3358	41	.	.	.
cord-001835-0s7ok4uw	3359	1	Degradation	degradation	NN
cord-001835-0s7ok4uw	3359	2	of	of	IN
cord-001835-0s7ok4uw	3359	3	yEGFP	yEGFP	NNP
cord-001835-0s7ok4uw	3359	4	and	and	CC
cord-001835-0s7ok4uw	3359	5	yEGFP	yEGFP	NNP
cord-001835-0s7ok4uw	3359	6	fusion	fusion	VBP
cord-001835-0s7ok4uw	3359	7	with	with	IN
cord-001835-0s7ok4uw	3359	8	degrons	degron	NNS
cord-001835-0s7ok4uw	3359	9	of	of	IN
cord-001835-0s7ok4uw	3359	10	ODC	ODC	NNP
cord-001835-0s7ok4uw	3359	11	(	(	-LRB-
cord-001835-0s7ok4uw	3359	12	degron	degron	NNP
cord-001835-0s7ok4uw	3359	13	-	-	HYPH
cord-001835-0s7ok4uw	3359	14	yEGFP	yEGFP	NNP
cord-001835-0s7ok4uw	3359	15	)	)	-RRB-
cord-001835-0s7ok4uw	3359	16	were	be	VBD
cord-001835-0s7ok4uw	3359	17	monitored	monitor	VBN
cord-001835-0s7ok4uw	3359	18	by	by	IN
cord-001835-0s7ok4uw	3359	19	western	western	JJ
cord-001835-0s7ok4uw	3359	20	blot	blot	NN
cord-001835-0s7ok4uw	3359	21	using	use	VBG
cord-001835-0s7ok4uw	3359	22	anti	anti	JJ
cord-001835-0s7ok4uw	3359	23	-	-	JJ
cord-001835-0s7ok4uw	3359	24	GFP	gfp	JJ
cord-001835-0s7ok4uw	3359	25	antibody	antibody	NN
cord-001835-0s7ok4uw	3359	26	and	and	CC
cord-001835-0s7ok4uw	3359	27	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3359	28	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	3359	29	.	.	.
cord-001835-0s7ok4uw	3360	1	Initially	initially	RB
cord-001835-0s7ok4uw	3360	2	,	,	,
cord-001835-0s7ok4uw	3360	3	the	the	DT
cord-001835-0s7ok4uw	3360	4	amount	amount	NN
cord-001835-0s7ok4uw	3360	5	of	of	IN
cord-001835-0s7ok4uw	3360	6	degron	degron	NNP
cord-001835-0s7ok4uw	3360	7	-	-	HYPH
cord-001835-0s7ok4uw	3360	8	yEGFP	yegfp	NN
cord-001835-0s7ok4uw	3360	9	fusion	fusion	NN
cord-001835-0s7ok4uw	3360	10	protein	protein	NN
cord-001835-0s7ok4uw	3360	11	was	be	VBD
cord-001835-0s7ok4uw	3360	12	very	very	RB
cord-001835-0s7ok4uw	3360	13	low	low	JJ
cord-001835-0s7ok4uw	3360	14	compared	compare	VBN
cord-001835-0s7ok4uw	3360	15	to	to	TO
cord-001835-0s7ok4uw	3360	16	control	control	VB
cord-001835-0s7ok4uw	3360	17	yEGFP	yegfp	PRP
cord-001835-0s7ok4uw	3360	18	.	.	.
cord-001835-0s7ok4uw	3361	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3361	2	means	mean	VBZ
cord-001835-0s7ok4uw	3361	3	that	that	IN
cord-001835-0s7ok4uw	3361	4	the	the	DT
cord-001835-0s7ok4uw	3361	5	chimeric	chimeric	JJ
cord-001835-0s7ok4uw	3361	6	protein	protein	NN
cord-001835-0s7ok4uw	3361	7	underwent	undergo	VBD
cord-001835-0s7ok4uw	3361	8	rapid	rapid	JJ
cord-001835-0s7ok4uw	3361	9	degradation	degradation	NN
cord-001835-0s7ok4uw	3361	10	in	in	IN
cord-001835-0s7ok4uw	3361	11	the	the	DT
cord-001835-0s7ok4uw	3361	12	cells	cell	NNS
cord-001835-0s7ok4uw	3361	13	.	.	.
cord-001835-0s7ok4uw	3362	1	After	after	IN
cord-001835-0s7ok4uw	3362	2	inhibition	inhibition	NN
cord-001835-0s7ok4uw	3362	3	of	of	IN
cord-001835-0s7ok4uw	3362	4	proteasome	proteasome	NN
cord-001835-0s7ok4uw	3362	5	,	,	,
cord-001835-0s7ok4uw	3362	6	increase	increase	VB
cord-001835-0s7ok4uw	3362	7	in	in	IN
cord-001835-0s7ok4uw	3362	8	the	the	DT
cord-001835-0s7ok4uw	3362	9	level	level	NN
cord-001835-0s7ok4uw	3362	10	of	of	IN
cord-001835-0s7ok4uw	3362	11	degron	degron	NNP
cord-001835-0s7ok4uw	3362	12	-	-	:
cord-001835-0s7ok4uw	3362	13	yEGFP	yEGFP	NNP
cord-001835-0s7ok4uw	3362	14	was	be	VBD
cord-001835-0s7ok4uw	3362	15	observed	observe	VBN
cord-001835-0s7ok4uw	3362	16	,	,	,
cord-001835-0s7ok4uw	3362	17	confirming	confirm	VBG
cord-001835-0s7ok4uw	3362	18	that	that	IN
cord-001835-0s7ok4uw	3362	19	the	the	DT
cord-001835-0s7ok4uw	3362	20	degrons	degron	NNS
cord-001835-0s7ok4uw	3362	21	cause	cause	VB
cord-001835-0s7ok4uw	3362	22	rapid	rapid	JJ
cord-001835-0s7ok4uw	3362	23	degradation	degradation	NN
cord-001835-0s7ok4uw	3362	24	of	of	IN
cord-001835-0s7ok4uw	3362	25	reporter	reporter	NN
cord-001835-0s7ok4uw	3362	26	protein	protein	NN
cord-001835-0s7ok4uw	3362	27	through	through	IN
cord-001835-0s7ok4uw	3362	28	proteasome	proteasome	NN
cord-001835-0s7ok4uw	3362	29	.	.	.
cord-001835-0s7ok4uw	3363	1	Earlier	early	RBR
cord-001835-0s7ok4uw	3363	2	,	,	,
cord-001835-0s7ok4uw	3363	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3363	4	have	have	VBP
cord-001835-0s7ok4uw	3363	5	also	also	RB
cord-001835-0s7ok4uw	3363	6	tagged	tag	VBN
cord-001835-0s7ok4uw	3363	7	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	3363	8	from	from	IN
cord-001835-0s7ok4uw	3363	9	yeast	yeast	NN
cord-001835-0s7ok4uw	3363	10	with	with	IN
cord-001835-0s7ok4uw	3363	11	last	last	JJ
cord-001835-0s7ok4uw	3363	12	37	37	CD
cord-001835-0s7ok4uw	3363	13	residues	residue	NNS
cord-001835-0s7ok4uw	3363	14	of	of	IN
cord-001835-0s7ok4uw	3363	15	mODC	modc	CD
cord-001835-0s7ok4uw	3363	16	and	and	CC
cord-001835-0s7ok4uw	3363	17	observed	observe	VBD
cord-001835-0s7ok4uw	3363	18	enhanced	enhanced	JJ
cord-001835-0s7ok4uw	3363	19	degradation	degradation	NN
cord-001835-0s7ok4uw	3363	20	of	of	IN
cord-001835-0s7ok4uw	3363	21	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	3363	22	in	in	IN
cord-001835-0s7ok4uw	3363	23	Saccharomyces	Saccharomyces	NNP
cord-001835-0s7ok4uw	3363	24	cerevisiae	cerevisiae	NNS
cord-001835-0s7ok4uw	3363	25	.	.	.
cord-001835-0s7ok4uw	3364	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	3364	2	,	,	,
cord-001835-0s7ok4uw	3364	3	both	both	CC
cord-001835-0s7ok4uw	3364	4	the	the	DT
cord-001835-0s7ok4uw	3364	5	degrons	degron	NNS
cord-001835-0s7ok4uw	3364	6	of	of	IN
cord-001835-0s7ok4uw	3364	7	ODC	ODC	NNP
cord-001835-0s7ok4uw	3364	8	alone	alone	JJ
cord-001835-0s7ok4uw	3364	9	and	and	CC
cord-001835-0s7ok4uw	3364	10	in	in	IN
cord-001835-0s7ok4uw	3364	11	combination	combination	NN
cord-001835-0s7ok4uw	3364	12	are	be	VBP
cord-001835-0s7ok4uw	3364	13	capable	capable	JJ
cord-001835-0s7ok4uw	3364	14	of	of	IN
cord-001835-0s7ok4uw	3364	15	decreasing	decrease	VBG
cord-001835-0s7ok4uw	3364	16	stability	stability	NN
cord-001835-0s7ok4uw	3364	17	of	of	IN
cord-001835-0s7ok4uw	3364	18	reporter	reporter	NN
cord-001835-0s7ok4uw	3364	19	protein	protein	NN
cord-001835-0s7ok4uw	3364	20	in	in	IN
cord-001835-0s7ok4uw	3364	21	the	the	DT
cord-001835-0s7ok4uw	3364	22	cells	cell	NNS
cord-001835-0s7ok4uw	3364	23	.	.	.
cord-001835-0s7ok4uw	3365	1	However	however	RB
cord-001835-0s7ok4uw	3365	2	,	,	,
cord-001835-0s7ok4uw	3365	3	the	the	DT
cord-001835-0s7ok4uw	3365	4	combination	combination	NN
cord-001835-0s7ok4uw	3365	5	of	of	IN
cord-001835-0s7ok4uw	3365	6	degrons	degron	NNS
cord-001835-0s7ok4uw	3365	7	is	be	VBZ
cord-001835-0s7ok4uw	3365	8	more	more	RBR
cord-001835-0s7ok4uw	3365	9	effective	effective	JJ
cord-001835-0s7ok4uw	3365	10	than	than	IN
cord-001835-0s7ok4uw	3365	11	either	either	DT
cord-001835-0s7ok4uw	3365	12	of	of	IN
cord-001835-0s7ok4uw	3365	13	them	-PRON-	PRP
cord-001835-0s7ok4uw	3365	14	in	in	IN
cord-001835-0s7ok4uw	3365	15	isolation	isolation	NN
cord-001835-0s7ok4uw	3365	16	.	.	.
cord-001835-0s7ok4uw	3365	17	 	 	_SP
cord-001835-0s7ok4uw	3366	1	Enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3366	2	fold	fold	VBP
cord-001835-0s7ok4uw	3366	3	into	into	IN
cord-001835-0s7ok4uw	3366	4	unique	unique	JJ
cord-001835-0s7ok4uw	3366	5	three	three	CD
cord-001835-0s7ok4uw	3366	6	-	-	HYPH
cord-001835-0s7ok4uw	3366	7	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	3366	8	structures	structure	NNS
cord-001835-0s7ok4uw	3366	9	,	,	,
cord-001835-0s7ok4uw	3366	10	which	which	WDT
cord-001835-0s7ok4uw	3366	11	underlie	underlie	VBP
cord-001835-0s7ok4uw	3366	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3366	13	remarkable	remarkable	JJ
cord-001835-0s7ok4uw	3366	14	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3366	15	properties	property	NNS
cord-001835-0s7ok4uw	3366	16	.	.	.
cord-001835-0s7ok4uw	3367	1	The	the	DT
cord-001835-0s7ok4uw	3367	2	requirement	requirement	NN
cord-001835-0s7ok4uw	3367	3	that	that	IN
cord-001835-0s7ok4uw	3367	4	they	-PRON-	PRP
cord-001835-0s7ok4uw	3367	5	be	be	VBP
cord-001835-0s7ok4uw	3367	6	stably	stably	RB
cord-001835-0s7ok4uw	3367	7	folded	fold	VBN
cord-001835-0s7ok4uw	3367	8	is	be	VBZ
cord-001835-0s7ok4uw	3367	9	a	a	DT
cord-001835-0s7ok4uw	3367	10	likely	likely	JJ
cord-001835-0s7ok4uw	3367	11	factor	factor	NN
cord-001835-0s7ok4uw	3367	12	that	that	WDT
cord-001835-0s7ok4uw	3367	13	contributes	contribute	VBZ
cord-001835-0s7ok4uw	3367	14	to	to	IN
cord-001835-0s7ok4uw	3367	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3367	16	relatively	relatively	RB
cord-001835-0s7ok4uw	3367	17	large	large	JJ
cord-001835-0s7ok4uw	3367	18	size	size	NN
cord-001835-0s7ok4uw	3367	19	(	(	-LRB-
cord-001835-0s7ok4uw	3367	20	>	>	VBZ
cord-001835-0s7ok4uw	3367	21	10,000	10,000	CD
cord-001835-0s7ok4uw	3367	22	Dalton	Dalton	NNP
cord-001835-0s7ok4uw	3367	23	)	)	-RRB-
cord-001835-0s7ok4uw	3367	24	.	.	.
cord-001835-0s7ok4uw	3368	1	However	however	RB
cord-001835-0s7ok4uw	3368	2	,	,	,
cord-001835-0s7ok4uw	3368	3	much	much	RB
cord-001835-0s7ok4uw	3368	4	shorter	short	JJR
cord-001835-0s7ok4uw	3368	5	peptides	peptide	NNS
cord-001835-0s7ok4uw	3368	6	can	can	MD
cord-001835-0s7ok4uw	3368	7	achieve	achieve	VB
cord-001835-0s7ok4uw	3368	8	well	well	RB
cord-001835-0s7ok4uw	3368	9	-	-	HYPH
cord-001835-0s7ok4uw	3368	10	defined	define	VBN
cord-001835-0s7ok4uw	3368	11	conformations	conformation	NNS
cord-001835-0s7ok4uw	3368	12	through	through	IN
cord-001835-0s7ok4uw	3368	13	the	the	DT
cord-001835-0s7ok4uw	3368	14	formation	formation	NN
cord-001835-0s7ok4uw	3368	15	of	of	IN
cord-001835-0s7ok4uw	3368	16	amyloid	amyloid	NN
cord-001835-0s7ok4uw	3368	17	fibrils	fibril	NNS
cord-001835-0s7ok4uw	3368	18	.	.	.
cord-001835-0s7ok4uw	3369	1	To	to	TO
cord-001835-0s7ok4uw	3369	2	test	test	VB
cord-001835-0s7ok4uw	3369	3	whether	whether	IN
cord-001835-0s7ok4uw	3369	4	short	short	JJ
cord-001835-0s7ok4uw	3369	5	amyloid	amyloid	NN
cord-001835-0s7ok4uw	3369	6	-	-	HYPH
cord-001835-0s7ok4uw	3369	7	forming	form	VBG
cord-001835-0s7ok4uw	3369	8	peptides	peptide	NNS
cord-001835-0s7ok4uw	3369	9	might	may	MD
cord-001835-0s7ok4uw	3369	10	in	in	IN
cord-001835-0s7ok4uw	3369	11	fact	fact	NN
cord-001835-0s7ok4uw	3369	12	be	be	VB
cord-001835-0s7ok4uw	3369	13	capable	capable	JJ
cord-001835-0s7ok4uw	3369	14	of	of	IN
cord-001835-0s7ok4uw	3369	15	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3369	16	-	-	HYPH
cord-001835-0s7ok4uw	3369	17	like	like	JJ
cord-001835-0s7ok4uw	3369	18	catalysis	catalysis	NN
cord-001835-0s7ok4uw	3369	19	,	,	,
cord-001835-0s7ok4uw	3369	20	we	-PRON-	PRP
cord-001835-0s7ok4uw	3369	21	designed	design	VBD
cord-001835-0s7ok4uw	3369	22	a	a	DT
cord-001835-0s7ok4uw	3369	23	series	series	NN
cord-001835-0s7ok4uw	3369	24	of	of	IN
cord-001835-0s7ok4uw	3369	25	7-residue	7-residue	CD
cord-001835-0s7ok4uw	3369	26	peptides	peptide	NNS
cord-001835-0s7ok4uw	3369	27	that	that	WDT
cord-001835-0s7ok4uw	3369	28	act	act	VBP
cord-001835-0s7ok4uw	3369	29	as	as	IN
cord-001835-0s7ok4uw	3369	30	Zn21dependent	zn21dependent	NN
cord-001835-0s7ok4uw	3369	31	esterases	esterase	NNS
cord-001835-0s7ok4uw	3369	32	.	.	.
cord-001835-0s7ok4uw	3370	1	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	3371	1	helps	help	VBZ
cord-001835-0s7ok4uw	3371	2	stabilize	stabilize	VB
cord-001835-0s7ok4uw	3371	3	the	the	DT
cord-001835-0s7ok4uw	3371	4	fibril	fibril	NNP
cord-001835-0s7ok4uw	3371	5	formation	formation	NN
cord-001835-0s7ok4uw	3371	6	,	,	,
cord-001835-0s7ok4uw	3371	7	while	while	IN
cord-001835-0s7ok4uw	3371	8	also	also	RB
cord-001835-0s7ok4uw	3371	9	acting	act	VBG
cord-001835-0s7ok4uw	3371	10	as	as	IN
cord-001835-0s7ok4uw	3371	11	a	a	DT
cord-001835-0s7ok4uw	3371	12	cofactor	cofactor	NN
cord-001835-0s7ok4uw	3371	13	to	to	TO
cord-001835-0s7ok4uw	3371	14	catalyze	catalyze	VB
cord-001835-0s7ok4uw	3371	15	acyl	acyl	NN
cord-001835-0s7ok4uw	3371	16	ester	ester	NN
cord-001835-0s7ok4uw	3371	17	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	3371	18	.	.	.
cord-001835-0s7ok4uw	3372	1	The	the	DT
cord-001835-0s7ok4uw	3372	2	fibril	fibril	NN
cord-001835-0s7ok4uw	3372	3	activity	activity	NN
cord-001835-0s7ok4uw	3372	4	is	be	VBZ
cord-001835-0s7ok4uw	3372	5	on	on	IN
cord-001835-0s7ok4uw	3372	6	par	par	NN
cord-001835-0s7ok4uw	3372	7	with	with	IN
cord-001835-0s7ok4uw	3372	8	the	the	DT
cord-001835-0s7ok4uw	3372	9	most	most	RBS
cord-001835-0s7ok4uw	3372	10	active	active	JJ
cord-001835-0s7ok4uw	3372	11	to	to	IN
cord-001835-0s7ok4uw	3372	12	date	date	NN
cord-001835-0s7ok4uw	3372	13	zinc	zinc	NN
cord-001835-0s7ok4uw	3372	14	-	-	HYPH
cord-001835-0s7ok4uw	3372	15	protein	protein	NN
cord-001835-0s7ok4uw	3372	16	complex	complex	NN
cord-001835-0s7ok4uw	3372	17	.	.	.
cord-001835-0s7ok4uw	3373	1	Such	such	JJ
cord-001835-0s7ok4uw	3373	2	remarkable	remarkable	JJ
cord-001835-0s7ok4uw	3373	3	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3373	4	is	be	VBZ
cord-001835-0s7ok4uw	3373	5	due	due	JJ
cord-001835-0s7ok4uw	3373	6	to	to	IN
cord-001835-0s7ok4uw	3373	7	the	the	DT
cord-001835-0s7ok4uw	3373	8	small	small	JJ
cord-001835-0s7ok4uw	3373	9	size	size	NN
cord-001835-0s7ok4uw	3373	10	of	of	IN
cord-001835-0s7ok4uw	3373	11	the	the	DT
cord-001835-0s7ok4uw	3373	12	active	active	JJ
cord-001835-0s7ok4uw	3373	13	unit	unit	NN
cord-001835-0s7ok4uw	3373	14	(	(	-LRB-
cord-001835-0s7ok4uw	3373	15	likely	likely	RB
cord-001835-0s7ok4uw	3373	16	a	a	DT
cord-001835-0s7ok4uw	3373	17	dimer	dimer	NN
cord-001835-0s7ok4uw	3373	18	of	of	IN
cord-001835-0s7ok4uw	3373	19	7-residue	7-residue	CD
cord-001835-0s7ok4uw	3373	20	peptides	peptide	NNS
cord-001835-0s7ok4uw	3373	21	)	)	-RRB-
cord-001835-0s7ok4uw	3373	22	,	,	,
cord-001835-0s7ok4uw	3373	23	while	while	IN
cord-001835-0s7ok4uw	3373	24	the	the	DT
cord-001835-0s7ok4uw	3373	25	protein	protein	NN
cord-001835-0s7ok4uw	3373	26	is	be	VBZ
cord-001835-0s7ok4uw	3373	27	at	at	IN
cord-001835-0s7ok4uw	3373	28	least	least	JJS
cord-001835-0s7ok4uw	3373	29	15-fold	15-fold	CD
cord-001835-0s7ok4uw	3373	30	larger	large	JJR
cord-001835-0s7ok4uw	3373	31	in	in	IN
cord-001835-0s7ok4uw	3373	32	molecular	molecular	JJ
cord-001835-0s7ok4uw	3373	33	weight	weight	NN
cord-001835-0s7ok4uw	3373	34	.	.	.
cord-001835-0s7ok4uw	3374	1	The	the	DT
cord-001835-0s7ok4uw	3374	2	observed	observed	JJ
cord-001835-0s7ok4uw	3374	3	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3374	4	activity	activity	NN
cord-001835-0s7ok4uw	3374	5	is	be	VBZ
cord-001835-0s7ok4uw	3374	6	not	not	RB
cord-001835-0s7ok4uw	3374	7	limited	limit	VBN
cord-001835-0s7ok4uw	3374	8	to	to	IN
cord-001835-0s7ok4uw	3374	9	ester	ester	NN
cord-001835-0s7ok4uw	3374	10	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	3374	11	.	.	.
cord-001835-0s7ok4uw	3375	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3375	2	have	have	VBP
cord-001835-0s7ok4uw	3375	3	designed	design	VBN
cord-001835-0s7ok4uw	3375	4	copper	copper	NN
cord-001835-0s7ok4uw	3375	5	binding	binding	NN
cord-001835-0s7ok4uw	3375	6	peptides	peptide	NNS
cord-001835-0s7ok4uw	3375	7	that	that	WDT
cord-001835-0s7ok4uw	3375	8	are	be	VBP
cord-001835-0s7ok4uw	3375	9	capable	capable	JJ
cord-001835-0s7ok4uw	3375	10	oxygen	oxygen	NN
cord-001835-0s7ok4uw	3375	11	activation	activation	NN
cord-001835-0s7ok4uw	3375	12	.	.	.
cord-001835-0s7ok4uw	3376	1	These	these	DT
cord-001835-0s7ok4uw	3376	2	results	result	NNS
cord-001835-0s7ok4uw	3376	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	3376	4	that	that	IN
cord-001835-0s7ok4uw	3376	5	prion	prion	NN
cord-001835-0s7ok4uw	3376	6	-	-	HYPH
cord-001835-0s7ok4uw	3376	7	like	like	JJ
cord-001835-0s7ok4uw	3376	8	fibrils	fibril	NNS
cord-001835-0s7ok4uw	3376	9	are	be	VBP
cord-001835-0s7ok4uw	3376	10	able	able	JJ
cord-001835-0s7ok4uw	3376	11	to	to	TO
cord-001835-0s7ok4uw	3376	12	not	not	RB
cord-001835-0s7ok4uw	3376	13	only	only	RB
cord-001835-0s7ok4uw	3376	14	catalyze	catalyze	VB
cord-001835-0s7ok4uw	3376	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3376	16	own	own	JJ
cord-001835-0s7ok4uw	3376	17	formation	formation	NN
cord-001835-0s7ok4uw	3376	18	-they	-they	:
cord-001835-0s7ok4uw	3376	19	also	also	RB
cord-001835-0s7ok4uw	3376	20	can	can	MD
cord-001835-0s7ok4uw	3376	21	catalyze	catalyze	VB
cord-001835-0s7ok4uw	3376	22	chemical	chemical	JJ
cord-001835-0s7ok4uw	3376	23	reactions	reaction	NNS
cord-001835-0s7ok4uw	3376	24	.	.	.
cord-001835-0s7ok4uw	3377	1	Thus	thus	RB
cord-001835-0s7ok4uw	3377	2	,	,	,
cord-001835-0s7ok4uw	3377	3	they	-PRON-	PRP
cord-001835-0s7ok4uw	3377	4	might	may	MD
cord-001835-0s7ok4uw	3377	5	have	have	VB
cord-001835-0s7ok4uw	3377	6	served	serve	VBN
cord-001835-0s7ok4uw	3377	7	as	as	IN
cord-001835-0s7ok4uw	3377	8	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	3377	9	in	in	IN
cord-001835-0s7ok4uw	3377	10	the	the	DT
cord-001835-0s7ok4uw	3377	11	evolution	evolution	NN
cord-001835-0s7ok4uw	3377	12	of	of	IN
cord-001835-0s7ok4uw	3377	13	modern	modern	JJ
cord-001835-0s7ok4uw	3377	14	-	-	HYPH
cord-001835-0s7ok4uw	3377	15	day	day	NN
cord-001835-0s7ok4uw	3377	16	metalloenzymes	metalloenzyme	NNS
cord-001835-0s7ok4uw	3377	17	.	.	.
cord-001835-0s7ok4uw	3378	1	These	these	DT
cord-001835-0s7ok4uw	3378	2	results	result	NNS
cord-001835-0s7ok4uw	3378	3	also	also	RB
cord-001835-0s7ok4uw	3378	4	have	have	VBP
cord-001835-0s7ok4uw	3378	5	implications	implication	NNS
cord-001835-0s7ok4uw	3378	6	for	for	IN
cord-001835-0s7ok4uw	3378	7	the	the	DT
cord-001835-0s7ok4uw	3378	8	design	design	NN
cord-001835-0s7ok4uw	3378	9	of	of	IN
cord-001835-0s7ok4uw	3378	10	self	self	NN
cord-001835-0s7ok4uw	3378	11	-	-	HYPH
cord-001835-0s7ok4uw	3378	12	assembling	assemble	VBG
cord-001835-0s7ok4uw	3378	13	nanostructured	nanostructured	JJ
cord-001835-0s7ok4uw	3378	14	catalysts	catalyst	NNS
cord-001835-0s7ok4uw	3378	15	including	include	VBG
cord-001835-0s7ok4uw	3378	16	ones	one	NNS
cord-001835-0s7ok4uw	3378	17	containing	contain	VBG
cord-001835-0s7ok4uw	3378	18	a	a	DT
cord-001835-0s7ok4uw	3378	19	variety	variety	NN
cord-001835-0s7ok4uw	3378	20	of	of	IN
cord-001835-0s7ok4uw	3378	21	biological	biological	JJ
cord-001835-0s7ok4uw	3378	22	and	and	CC
cord-001835-0s7ok4uw	3378	23	nonbiological	nonbiological	JJ
cord-001835-0s7ok4uw	3378	24	metal	metal	NN
cord-001835-0s7ok4uw	3378	25	ions	ion	NNS
cord-001835-0s7ok4uw	3378	26	.	.	.
cord-001835-0s7ok4uw	3379	1	Rational	rational	JJ
cord-001835-0s7ok4uw	3379	2	design	design	NN
cord-001835-0s7ok4uw	3379	3	of	of	IN
cord-001835-0s7ok4uw	3379	4	the	the	DT
cord-001835-0s7ok4uw	3379	5	cold	cold	JJ
cord-001835-0s7ok4uw	3379	6	active	active	JJ
cord-001835-0s7ok4uw	3379	7	subtilisin	subtilisin	NNP
cord-001835-0s7ok4uw	3379	8	-	-	HYPH
cord-001835-0s7ok4uw	3379	9	like	like	JJ
cord-001835-0s7ok4uw	3379	10	serine	serine	NN
cord-001835-0s7ok4uw	3379	11	protease	protease	NN
cord-001835-0s7ok4uw	3379	12	VPR	VPR	NNP
cord-001835-0s7ok4uw	3379	13	with	with	IN
cord-001835-0s7ok4uw	3379	14	improved	improved	JJ
cord-001835-0s7ok4uw	3379	15	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3379	16	properties	property	NNS
cord-001835-0s7ok4uw	3379	17	and	and	CC
cord-001835-0s7ok4uw	3379	18	thermal	thermal	JJ
cord-001835-0s7ok4uw	3379	19	stability	stability	NN
cord-001835-0s7ok4uw	3379	20	ABSTRACT	abstract	JJ
cord-001835-0s7ok4uw	3379	21	proteinase	proteinase	NN
cord-001835-0s7ok4uw	3379	22	VPR	VPR	NNP
cord-001835-0s7ok4uw	3379	23	,	,	,
cord-001835-0s7ok4uw	3379	24	from	from	IN
cord-001835-0s7ok4uw	3379	25	a	a	DT
cord-001835-0s7ok4uw	3379	26	psychrophilic	psychrophilic	NN
cord-001835-0s7ok4uw	3379	27	Vibrio	Vibrio	NNP
cord-001835-0s7ok4uw	3379	28	species	specie	NNS
cord-001835-0s7ok4uw	3379	29	and	and	CC
cord-001835-0s7ok4uw	3379	30	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3379	31	thermophilic	thermophilic	JJ
cord-001835-0s7ok4uw	3379	32	structural	structural	JJ
cord-001835-0s7ok4uw	3379	33	homologue	homologue	NN
cord-001835-0s7ok4uw	3379	34	,	,	,
cord-001835-0s7ok4uw	3379	35	aqualysin	aqualysin	NNP
cord-001835-0s7ok4uw	3379	36	I	i	NN
cord-001835-0s7ok4uw	3379	37	(	(	-LRB-
cord-001835-0s7ok4uw	3379	38	AQUI	AQUI	NNP
cord-001835-0s7ok4uw	3379	39	)	)	-RRB-
cord-001835-0s7ok4uw	3379	40	from	from	IN
cord-001835-0s7ok4uw	3379	41	Thermus	Thermus	NNP
cord-001835-0s7ok4uw	3379	42	aquaticus	aquaticus	NNP
cord-001835-0s7ok4uw	3379	43	,	,	,
cord-001835-0s7ok4uw	3379	44	we	-PRON-	PRP
cord-001835-0s7ok4uw	3379	45	set	set	VBD
cord-001835-0s7ok4uw	3379	46	out	out	RP
cord-001835-0s7ok4uw	3379	47	to	to	TO
cord-001835-0s7ok4uw	3379	48	design	design	VB
cord-001835-0s7ok4uw	3379	49	a	a	DT
cord-001835-0s7ok4uw	3379	50	mutant	mutant	NN
cord-001835-0s7ok4uw	3379	51	of	of	IN
cord-001835-0s7ok4uw	3379	52	VPR	VPR	NNP
cord-001835-0s7ok4uw	3379	53	which	which	WDT
cord-001835-0s7ok4uw	3379	54	would	would	MD
cord-001835-0s7ok4uw	3379	55	be	be	VB
cord-001835-0s7ok4uw	3379	56	more	more	RBR
cord-001835-0s7ok4uw	3379	57	thermostable	thermostable	JJ
cord-001835-0s7ok4uw	3379	58	,	,	,
cord-001835-0s7ok4uw	3379	59	but	but	CC
cord-001835-0s7ok4uw	3379	60	would	would	MD
cord-001835-0s7ok4uw	3379	61	retain	retain	VB
cord-001835-0s7ok4uw	3379	62	the	the	DT
cord-001835-0s7ok4uw	3379	63	high	high	JJ
cord-001835-0s7ok4uw	3379	64	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3379	65	activity	activity	NN
cord-001835-0s7ok4uw	3379	66	of	of	IN
cord-001835-0s7ok4uw	3379	67	the	the	DT
cord-001835-0s7ok4uw	3379	68	wild	wild	JJ
cord-001835-0s7ok4uw	3379	69	type	type	NN
cord-001835-0s7ok4uw	3379	70	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3379	71	.	.	.
cord-001835-0s7ok4uw	3380	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3380	2	starting	start	VBG
cord-001835-0s7ok4uw	3380	3	protein	protein	NN
cord-001835-0s7ok4uw	3380	4	template	template	NN
cord-001835-0s7ok4uw	3380	5	was	be	VBD
cord-001835-0s7ok4uw	3380	6	a	a	DT
cord-001835-0s7ok4uw	3380	7	previously	previously	RB
cord-001835-0s7ok4uw	3380	8	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	3380	9	mutant	mutant	NN
cord-001835-0s7ok4uw	3380	10	containing	contain	VBG
cord-001835-0s7ok4uw	3380	11	two	two	CD
cord-001835-0s7ok4uw	3380	12	inserted	insert	VBN
cord-001835-0s7ok4uw	3380	13	proline	proline	NN
cord-001835-0s7ok4uw	3380	14	residues	residue	NNS
cord-001835-0s7ok4uw	3380	15	close	close	RB
cord-001835-0s7ok4uw	3380	16	to	to	IN
cord-001835-0s7ok4uw	3380	17	the	the	DT
cord-001835-0s7ok4uw	3380	18	Nterminus	Nterminus	NNP
cord-001835-0s7ok4uw	3380	19	of	of	IN
cord-001835-0s7ok4uw	3380	20	VPR	VPR	NNP
cord-001835-0s7ok4uw	3380	21	(	(	-LRB-
cord-001835-0s7ok4uw	3380	22	N3P	n3p	NN
cord-001835-0s7ok4uw	3380	23	/	/	SYM
cord-001835-0s7ok4uw	3380	24	I5P	i5p	NN
cord-001835-0s7ok4uw	3380	25	)	)	-RRB-
cord-001835-0s7ok4uw	3380	26	.	.	.
cord-001835-0s7ok4uw	3381	1	This	this	DT
cord-001835-0s7ok4uw	3381	2	VPR_N3P	VPR_N3P	NNP
cord-001835-0s7ok4uw	3381	3	/	/	SYM
cord-001835-0s7ok4uw	3381	4	I5P	i5p	NN
cord-001835-0s7ok4uw	3381	5	mutant	mutant	NN
cord-001835-0s7ok4uw	3381	6	was	be	VBD
cord-001835-0s7ok4uw	3381	7	shown	show	VBN
cord-001835-0s7ok4uw	3381	8	to	to	TO
cord-001835-0s7ok4uw	3381	9	have	have	VB
cord-001835-0s7ok4uw	3381	10	a	a	DT
cord-001835-0s7ok4uw	3381	11	significantly	significantly	RB
cord-001835-0s7ok4uw	3381	12	increased	increase	VBN
cord-001835-0s7ok4uw	3381	13	thermal	thermal	JJ
cord-001835-0s7ok4uw	3381	14	stability	stability	NN
cord-001835-0s7ok4uw	3381	15	but	but	CC
cord-001835-0s7ok4uw	3381	16	displayed	display	VBD
cord-001835-0s7ok4uw	3381	17	a	a	DT
cord-001835-0s7ok4uw	3381	18	concomitant	concomitant	JJ
cord-001835-0s7ok4uw	3381	19	tenfold	tenfold	JJ
cord-001835-0s7ok4uw	3381	20	loss	loss	NN
cord-001835-0s7ok4uw	3381	21	of	of	IN
cord-001835-0s7ok4uw	3381	22	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3381	23	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3381	24	.	.	.
cord-001835-0s7ok4uw	3382	1	From	from	IN
cord-001835-0s7ok4uw	3382	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3382	3	previous	previous	JJ
cord-001835-0s7ok4uw	3382	4	studies	study	NNS
cord-001835-0s7ok4uw	3382	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3382	6	selected	select	VBD
cord-001835-0s7ok4uw	3382	7	two	two	CD
cord-001835-0s7ok4uw	3382	8	mutations	mutation	NNS
cord-001835-0s7ok4uw	3382	9	,	,	,
cord-001835-0s7ok4uw	3382	10	one	one	CD
cord-001835-0s7ok4uw	3382	11	which	which	WDT
cord-001835-0s7ok4uw	3382	12	increased	increase	VBD
cord-001835-0s7ok4uw	3382	13	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3382	14	activity	activity	NN
cord-001835-0s7ok4uw	3382	15	(	(	-LRB-
cord-001835-0s7ok4uw	3382	16	Q142	Q142	NNP
cord-001835-0s7ok4uw	3382	17	K	K	NNP
cord-001835-0s7ok4uw	3382	18	)	)	-RRB-
cord-001835-0s7ok4uw	3382	19	of	of	IN
cord-001835-0s7ok4uw	3382	20	the	the	DT
cord-001835-0s7ok4uw	3382	21	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3382	22	significantly	significantly	RB
cord-001835-0s7ok4uw	3382	23	and	and	CC
cord-001835-0s7ok4uw	3382	24	another	another	DT
cord-001835-0s7ok4uw	3382	25	which	which	WDT
cord-001835-0s7ok4uw	3382	26	stabilized	stabilize	VBD
cord-001835-0s7ok4uw	3382	27	the	the	DT
cord-001835-0s7ok4uw	3382	28	protein	protein	NN
cord-001835-0s7ok4uw	3382	29	against	against	IN
cord-001835-0s7ok4uw	3382	30	thermal	thermal	JJ
cord-001835-0s7ok4uw	3382	31	denaturation	denaturation	NN
cord-001835-0s7ok4uw	3382	32	(	(	-LRB-
cord-001835-0s7ok4uw	3382	33	N15D	N15D	NNP
cord-001835-0s7ok4uw	3382	34	)	)	-RRB-
cord-001835-0s7ok4uw	3382	35	.	.	.
cord-001835-0s7ok4uw	3383	1	The	the	DT
cord-001835-0s7ok4uw	3383	2	N15D	N15D	NNP
cord-001835-0s7ok4uw	3383	3	mutation	mutation	NN
cord-001835-0s7ok4uw	3383	4	had	have	VBD
cord-001835-0s7ok4uw	3383	5	been	be	VBN
cord-001835-0s7ok4uw	3383	6	shown	show	VBN
cord-001835-0s7ok4uw	3383	7	to	to	TO
cord-001835-0s7ok4uw	3383	8	introduce	introduce	VB
cord-001835-0s7ok4uw	3383	9	a	a	DT
cord-001835-0s7ok4uw	3383	10	salt	salt	NN
cord-001835-0s7ok4uw	3383	11	bridge	bridge	NN
cord-001835-0s7ok4uw	3383	12	into	into	IN
cord-001835-0s7ok4uw	3383	13	the	the	DT
cord-001835-0s7ok4uw	3383	14	structure	structure	NN
cord-001835-0s7ok4uw	3383	15	of	of	IN
cord-001835-0s7ok4uw	3383	16	the	the	DT
cord-001835-0s7ok4uw	3383	17	cold	cold	JJ
cord-001835-0s7ok4uw	3383	18	adapted	adapt	VBN
cord-001835-0s7ok4uw	3383	19	proteinase	proteinase	NN
cord-001835-0s7ok4uw	3383	20	,	,	,
cord-001835-0s7ok4uw	3383	21	yielding	yield	VBG
cord-001835-0s7ok4uw	3383	22	higher	high	JJR
cord-001835-0s7ok4uw	3383	23	stability	stability	NN
cord-001835-0s7ok4uw	3383	24	but	but	CC
cord-001835-0s7ok4uw	3383	25	without	without	IN
cord-001835-0s7ok4uw	3383	26	negative	negative	JJ
cord-001835-0s7ok4uw	3383	27	effects	effect	NNS
cord-001835-0s7ok4uw	3383	28	on	on	IN
cord-001835-0s7ok4uw	3383	29	activity	activity	NN
cord-001835-0s7ok4uw	3383	30	.	.	.
cord-001835-0s7ok4uw	3384	1	The	the	DT
cord-001835-0s7ok4uw	3384	2	Q142	Q142	NNPS
cord-001835-0s7ok4uw	3384	3	K	K	NNP
cord-001835-0s7ok4uw	3384	4	exchange	exchange	NN
cord-001835-0s7ok4uw	3384	5	had	have	VBD
cord-001835-0s7ok4uw	3384	6	been	be	VBN
cord-001835-0s7ok4uw	3384	7	shown	show	VBN
cord-001835-0s7ok4uw	3384	8	to	to	TO
cord-001835-0s7ok4uw	3384	9	double	double	VB
cord-001835-0s7ok4uw	3384	10	the	the	DT
cord-001835-0s7ok4uw	3384	11	turnover	turnover	NN
cord-001835-0s7ok4uw	3384	12	number	number	NN
cord-001835-0s7ok4uw	3384	13	(	(	-LRB-
cord-001835-0s7ok4uw	3384	14	kcat	kcat	NNP
cord-001835-0s7ok4uw	3384	15	)	)	-RRB-
cord-001835-0s7ok4uw	3384	16	to	to	IN
cord-001835-0s7ok4uw	3384	17	that	that	DT
cord-001835-0s7ok4uw	3384	18	of	of	IN
cord-001835-0s7ok4uw	3384	19	the	the	DT
cord-001835-0s7ok4uw	3384	20	wild	wild	JJ
cord-001835-0s7ok4uw	3384	21	type	type	NN
cord-001835-0s7ok4uw	3384	22	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3384	23	.	.	.
cord-001835-0s7ok4uw	3385	1	Insertions	insertion	NNS
cord-001835-0s7ok4uw	3385	2	of	of	IN
cord-001835-0s7ok4uw	3385	3	these	these	DT
cord-001835-0s7ok4uw	3385	4	selected	select	VBN
cord-001835-0s7ok4uw	3385	5	mutations	mutation	NNS
cord-001835-0s7ok4uw	3385	6	into	into	IN
cord-001835-0s7ok4uw	3385	7	the	the	DT
cord-001835-0s7ok4uw	3385	8	VPR_N3P	VPR_N3P	NNP
cord-001835-0s7ok4uw	3385	9	/	/	SYM
cord-001835-0s7ok4uw	3385	10	I5P	i5p	NN
cord-001835-0s7ok4uw	3385	11	mutant	mutant	NN
cord-001835-0s7ok4uw	3385	12	were	be	VBD
cord-001835-0s7ok4uw	3385	13	according	accord	VBG
cord-001835-0s7ok4uw	3385	14	to	to	IN
cord-001835-0s7ok4uw	3385	15	predictions	prediction	NNS
cord-001835-0s7ok4uw	3385	16	;	;	:
cord-001835-0s7ok4uw	3385	17	the	the	DT
cord-001835-0s7ok4uw	3385	18	Q142	Q142	NNP
cord-001835-0s7ok4uw	3385	19	K	K	NNP
cord-001835-0s7ok4uw	3385	20	increased	increase	VBD
cord-001835-0s7ok4uw	3385	21	the	the	DT
cord-001835-0s7ok4uw	3385	22	kcat	kcat	NNP
cord-001835-0s7ok4uw	3385	23	tenfold	tenfold	RB
cord-001835-0s7ok4uw	3385	24	,	,	,
cord-001835-0s7ok4uw	3385	25	and	and	CC
cord-001835-0s7ok4uw	3385	26	the	the	DT
cord-001835-0s7ok4uw	3385	27	N15D	N15D	NNP
cord-001835-0s7ok4uw	3385	28	mutation	mutation	NN
cord-001835-0s7ok4uw	3385	29	increased	increase	VBD
cord-001835-0s7ok4uw	3385	30	the	the	DT
cord-001835-0s7ok4uw	3385	31	thermal	thermal	JJ
cord-001835-0s7ok4uw	3385	32	stability	stability	NN
cord-001835-0s7ok4uw	3385	33	.	.	.
cord-001835-0s7ok4uw	3386	1	In	in	IN
cord-001835-0s7ok4uw	3386	2	the	the	DT
cord-001835-0s7ok4uw	3386	3	combination	combination	NN
cord-001835-0s7ok4uw	3386	4	mutant	mutant	NN
cord-001835-0s7ok4uw	3386	5	,	,	.
cord-001835-0s7ok4uw	3387	1	VPR_N3P	VPR_N3P	NNP
cord-001835-0s7ok4uw	3387	2	/	/	SYM
cord-001835-0s7ok4uw	3387	3	I5P	I5P	NNP
cord-001835-0s7ok4uw	3387	4	/	/	SYM
cord-001835-0s7ok4uw	3387	5	N15D	N15D	NNP
cord-001835-0s7ok4uw	3387	6	/	/	SYM
cord-001835-0s7ok4uw	3387	7	Q142	Q142	NNP
cord-001835-0s7ok4uw	3387	8	K	K	NNP
cord-001835-0s7ok4uw	3387	9	,	,	,
cord-001835-0s7ok4uw	3387	10	thermal	thermal	JJ
cord-001835-0s7ok4uw	3387	11	stability	stability	NN
cord-001835-0s7ok4uw	3387	12	was	be	VBD
cord-001835-0s7ok4uw	3387	13	increased	increase	VBN
cord-001835-0s7ok4uw	3387	14	by	by	IN
cord-001835-0s7ok4uw	3387	15	88C	88c	CD
cord-001835-0s7ok4uw	3387	16	and	and	CC
cord-001835-0s7ok4uw	3387	17	108C	108c	CD
cord-001835-0s7ok4uw	3387	18	,	,	,
cord-001835-0s7ok4uw	3387	19	in	in	IN
cord-001835-0s7ok4uw	3387	20	terms	term	NNS
cord-001835-0s7ok4uw	3387	21	of	of	IN
cord-001835-0s7ok4uw	3387	22	Tm	Tm	NNP
cord-001835-0s7ok4uw	3387	23	and	and	CC
cord-001835-0s7ok4uw	3387	24	T50	T50	NNP
cord-001835-0s7ok4uw	3387	25	%	%	NN
cord-001835-0s7ok4uw	3387	26	,	,	,
cord-001835-0s7ok4uw	3387	27	respectively	respectively	RB
cord-001835-0s7ok4uw	3387	28	.	.	.
cord-001835-0s7ok4uw	3388	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	3388	2	,	,	,
cord-001835-0s7ok4uw	3388	3	the	the	DT
cord-001835-0s7ok4uw	3388	4	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3388	5	activity	activity	NN
cord-001835-0s7ok4uw	3388	6	of	of	IN
cord-001835-0s7ok4uw	3388	7	the	the	DT
cord-001835-0s7ok4uw	3388	8	mutant	mutant	NN
cord-001835-0s7ok4uw	3388	9	was	be	VBD
cord-001835-0s7ok4uw	3388	10	somewhat	somewhat	RB
cord-001835-0s7ok4uw	3388	11	higher	high	JJR
cord-001835-0s7ok4uw	3388	12	than	than	IN
cord-001835-0s7ok4uw	3388	13	that	that	DT
cord-001835-0s7ok4uw	3388	14	of	of	IN
cord-001835-0s7ok4uw	3388	15	the	the	DT
cord-001835-0s7ok4uw	3388	16	wild	wild	JJ
cord-001835-0s7ok4uw	3388	17	type	type	NN
cord-001835-0s7ok4uw	3388	18	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3388	19	.	.	.
cord-001835-0s7ok4uw	3389	1	Critical	critical	JJ
cord-001835-0s7ok4uw	3389	2	peptide	peptide	NN
cord-001835-0s7ok4uw	3389	3	stretches	stretch	NNS
cord-001835-0s7ok4uw	3389	4	may	may	MD
cord-001835-0s7ok4uw	3389	5	not	not	RB
cord-001835-0s7ok4uw	3389	6	serve	serve	VB
cord-001835-0s7ok4uw	3389	7	as	as	IN
cord-001835-0s7ok4uw	3389	8	faithful	faithful	JJ
cord-001835-0s7ok4uw	3389	9	experimental	experimental	JJ
cord-001835-0s7ok4uw	3389	10	mimics	mimic	NNS
cord-001835-0s7ok4uw	3389	11	for	for	IN
cord-001835-0s7ok4uw	3389	12	protein	protein	NN
cord-001835-0s7ok4uw	3389	13	amyloidogenesis	amyloidogenesis	NN
cord-001835-0s7ok4uw	3389	14	Bishwajit	Bishwajit	NNP
cord-001835-0s7ok4uw	3389	15	Kundu	Kundu	NNP
cord-001835-0s7ok4uw	3389	16	1	1	CD
cord-001835-0s7ok4uw	3389	17	,	,	,
cord-001835-0s7ok4uw	3389	18	Dushyant	Dushyant	NNP
cord-001835-0s7ok4uw	3389	19	Garg	Garg	NNP
cord-001835-0s7ok4uw	3389	20	1	1	CD
cord-001835-0s7ok4uw	3389	21	1	1	CD
cord-001835-0s7ok4uw	3389	22	Certain	certain	JJ
cord-001835-0s7ok4uw	3389	23	amino	amino	NN
cord-001835-0s7ok4uw	3389	24	acid	acid	NN
cord-001835-0s7ok4uw	3389	25	stretches	stretch	NNS
cord-001835-0s7ok4uw	3389	26	are	be	VBP
cord-001835-0s7ok4uw	3389	27	considered	consider	VBN
cord-001835-0s7ok4uw	3389	28	critical	critical	JJ
cord-001835-0s7ok4uw	3389	29	to	to	TO
cord-001835-0s7ok4uw	3389	30	trigger	trigger	VB
cord-001835-0s7ok4uw	3389	31	the	the	DT
cord-001835-0s7ok4uw	3389	32	amyloidogenesis	amyloidogenesis	NN
cord-001835-0s7ok4uw	3389	33	in	in	IN
cord-001835-0s7ok4uw	3389	34	a	a	DT
cord-001835-0s7ok4uw	3389	35	protein	protein	NN
cord-001835-0s7ok4uw	3389	36	.	.	.
cord-001835-0s7ok4uw	3390	1	These	these	DT
cord-001835-0s7ok4uw	3390	2	peptide	peptide	NN
cord-001835-0s7ok4uw	3390	3	stretches	stretch	NNS
cord-001835-0s7ok4uw	3390	4	are	be	VBP
cord-001835-0s7ok4uw	3390	5	often	often	RB
cord-001835-0s7ok4uw	3390	6	synthetically	synthetically	RB
cord-001835-0s7ok4uw	3390	7	produced	produce	VBN
cord-001835-0s7ok4uw	3390	8	to	to	TO
cord-001835-0s7ok4uw	3390	9	serve	serve	VB
cord-001835-0s7ok4uw	3390	10	as	as	IN
cord-001835-0s7ok4uw	3390	11	experimental	experimental	JJ
cord-001835-0s7ok4uw	3390	12	mimics	mimic	NNS
cord-001835-0s7ok4uw	3390	13	for	for	IN
cord-001835-0s7ok4uw	3390	14	studying	study	VBG
cord-001835-0s7ok4uw	3390	15	amyloidogenesis	amyloidogenesis	NN
cord-001835-0s7ok4uw	3390	16	of	of	IN
cord-001835-0s7ok4uw	3390	17	the	the	DT
cord-001835-0s7ok4uw	3390	18	parent	parent	NN
cord-001835-0s7ok4uw	3390	19	protein	protein	NN
cord-001835-0s7ok4uw	3390	20	.	.	.
cord-001835-0s7ok4uw	3391	1	Here	here	RB
cord-001835-0s7ok4uw	3391	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3391	3	provide	provide	VBP
cord-001835-0s7ok4uw	3391	4	evidence	evidence	NN
cord-001835-0s7ok4uw	3391	5	that	that	IN
cord-001835-0s7ok4uw	3391	6	such	such	JJ
cord-001835-0s7ok4uw	3391	7	simple	simple	JJ
cord-001835-0s7ok4uw	3391	8	extrapolation	extrapolation	NN
cord-001835-0s7ok4uw	3391	9	may	may	MD
cord-001835-0s7ok4uw	3391	10	be	be	VB
cord-001835-0s7ok4uw	3391	11	misleading	misleading	JJ
cord-001835-0s7ok4uw	3391	12	.	.	.
cord-001835-0s7ok4uw	3392	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3392	2	studied	study	VBD
cord-001835-0s7ok4uw	3392	3	the	the	DT
cord-001835-0s7ok4uw	3392	4	amyloidogenesis	amyloidogenesis	NN
cord-001835-0s7ok4uw	3392	5	of	of	IN
cord-001835-0s7ok4uw	3392	6	full	full	JJ
cord-001835-0s7ok4uw	3392	7	length	length	NN
cord-001835-0s7ok4uw	3392	8	bovine	bovine	JJ
cord-001835-0s7ok4uw	3392	9	carbonic	carbonic	JJ
cord-001835-0s7ok4uw	3392	10	anhydrase	anhydrase	NN
cord-001835-0s7ok4uw	3392	11	II	II	NNP
cord-001835-0s7ok4uw	3392	12	(	(	-LRB-
cord-001835-0s7ok4uw	3392	13	BCAII	BCAII	NNP
cord-001835-0s7ok4uw	3392	14	)	)	-RRB-
cord-001835-0s7ok4uw	3392	15	and	and	CC
cord-001835-0s7ok4uw	3392	16	compared	compare	VBD
cord-001835-0s7ok4uw	3392	17	it	-PRON-	PRP
cord-001835-0s7ok4uw	3392	18	with	with	IN
cord-001835-0s7ok4uw	3392	19	those	those	DT
cord-001835-0s7ok4uw	3392	20	formed	form	VBN
cord-001835-0s7ok4uw	3392	21	by	by	IN
cord-001835-0s7ok4uw	3392	22	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3392	23	critical	critical	JJ
cord-001835-0s7ok4uw	3392	24	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	3392	25	peptide	peptide	NN
cord-001835-0s7ok4uw	3392	26	stretch	stretch	VBP
cord-001835-0s7ok4uw	3392	27	201	201	CD
cord-001835-0s7ok4uw	3392	28	-	-	SYM
cord-001835-0s7ok4uw	3392	29	227	227	CD
cord-001835-0s7ok4uw	3392	30	(	(	-LRB-
cord-001835-0s7ok4uw	3392	31	PepB	PepB	NNP
cord-001835-0s7ok4uw	3392	32	)	)	-RRB-
cord-001835-0s7ok4uw	3392	33	.	.	.
cord-001835-0s7ok4uw	3393	1	Under	under	IN
cord-001835-0s7ok4uw	3393	2	similar	similar	JJ
cord-001835-0s7ok4uw	3393	3	solution	solution	NN
cord-001835-0s7ok4uw	3393	4	conditions	condition	NNS
cord-001835-0s7ok4uw	3393	5	and	and	CC
cord-001835-0s7ok4uw	3393	6	initial	initial	JJ
cord-001835-0s7ok4uw	3393	7	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	3393	8	concentrations	concentration	NNS
cord-001835-0s7ok4uw	3393	9	,	,	,
cord-001835-0s7ok4uw	3393	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	3393	11	found	find	VBD
cord-001835-0s7ok4uw	3393	12	that	that	IN
cord-001835-0s7ok4uw	3393	13	while	while	IN
cord-001835-0s7ok4uw	3393	14	amyloid	amyloid	NN
cord-001835-0s7ok4uw	3393	15	formation	formation	NN
cord-001835-0s7ok4uw	3393	16	by	by	IN
cord-001835-0s7ok4uw	3393	17	BCAII	BCAII	NNP
cord-001835-0s7ok4uw	3393	18	followed	follow	VBD
cord-001835-0s7ok4uw	3393	19	aggregation	aggregation	NN
cord-001835-0s7ok4uw	3393	20	kinetics	kinetics	NN
cord-001835-0s7ok4uw	3393	21	dominated	dominate	VBN
cord-001835-0s7ok4uw	3393	22	by	by	IN
cord-001835-0s7ok4uw	3393	23	surface	surface	NN
cord-001835-0s7ok4uw	3393	24	-	-	HYPH
cord-001835-0s7ok4uw	3393	25	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	3393	26	secondary	secondary	JJ
cord-001835-0s7ok4uw	3393	27	nucleation	nucleation	NN
cord-001835-0s7ok4uw	3393	28	,	,	,
cord-001835-0s7ok4uw	3393	29	PepB	PepB	NNP
cord-001835-0s7ok4uw	3393	30	followed	follow	VBD
cord-001835-0s7ok4uw	3393	31	classical	classical	JJ
cord-001835-0s7ok4uw	3393	32	nucleation	nucleation	NN
cord-001835-0s7ok4uw	3393	33	-	-	HYPH
cord-001835-0s7ok4uw	3393	34	dependent	dependent	JJ
cord-001835-0s7ok4uw	3393	35	pathway	pathway	NN
cord-001835-0s7ok4uw	3393	36	.	.	.
cord-001835-0s7ok4uw	3394	1	The	the	DT
cord-001835-0s7ok4uw	3394	2	AFM	AFM	NNP
cord-001835-0s7ok4uw	3394	3	images	image	NNS
cord-001835-0s7ok4uw	3394	4	showed	show	VBD
cord-001835-0s7ok4uw	3394	5	that	that	IN
cord-001835-0s7ok4uw	3394	6	BCAII	BCAII	NNP
cord-001835-0s7ok4uw	3394	7	forms	form	VBZ
cord-001835-0s7ok4uw	3394	8	short	short	JJ
cord-001835-0s7ok4uw	3394	9	,	,	,
cord-001835-0s7ok4uw	3394	10	thick	thick	JJ
cord-001835-0s7ok4uw	3394	11	and	and	CC
cord-001835-0s7ok4uw	3394	12	branched	branched	JJ
cord-001835-0s7ok4uw	3394	13	fibrils	fibril	NNS
cord-001835-0s7ok4uw	3394	14	,	,	,
cord-001835-0s7ok4uw	3394	15	whereas	whereas	IN
cord-001835-0s7ok4uw	3394	16	PepB	PepB	NNP
cord-001835-0s7ok4uw	3394	17	formed	form	VBD
cord-001835-0s7ok4uw	3394	18	thin	thin	JJ
cord-001835-0s7ok4uw	3394	19	,	,	,
cord-001835-0s7ok4uw	3394	20	long	long	JJ
cord-001835-0s7ok4uw	3394	21	and	and	CC
cord-001835-0s7ok4uw	3394	22	unbranched	unbranched	JJ
cord-001835-0s7ok4uw	3394	23	fibrils	fibril	NNS
cord-001835-0s7ok4uw	3394	24	.	.	.
cord-001835-0s7ok4uw	3395	1	ATR	ATR	NNP
cord-001835-0s7ok4uw	3395	2	-	-	HYPH
cord-001835-0s7ok4uw	3395	3	FTIR	FTIR	NNP
cord-001835-0s7ok4uw	3395	4	revealed	reveal	VBD
cord-001835-0s7ok4uw	3395	5	parallel	parallel	JJ
cord-001835-0s7ok4uw	3395	6	arrangement	arrangement	NN
cord-001835-0s7ok4uw	3395	7	of	of	IN
cord-001835-0s7ok4uw	3395	8	cross	cross	NNP
cord-001835-0s7ok4uw	3395	9	b	b	NNP
cord-001835-0s7ok4uw	3395	10	sheet	sheet	NN
cord-001835-0s7ok4uw	3395	11	in	in	IN
cord-001835-0s7ok4uw	3395	12	BCAII	BCAII	NNP
cord-001835-0s7ok4uw	3395	13	amyloids	amyloids	NNP
cord-001835-0s7ok4uw	3395	14	,	,	,
cord-001835-0s7ok4uw	3395	15	while	while	IN
cord-001835-0s7ok4uw	3395	16	PepB	PepB	NNP
cord-001835-0s7ok4uw	3395	17	arranged	arrange	VBD
cord-001835-0s7ok4uw	3395	18	into	into	IN
cord-001835-0s7ok4uw	3395	19	antiparallel	antiparallel	NN
cord-001835-0s7ok4uw	3395	20	b	b	NN
cord-001835-0s7ok4uw	3395	21	sheets	sheet	NNS
cord-001835-0s7ok4uw	3395	22	.	.	.
cord-001835-0s7ok4uw	3396	1	Amyloids	Amyloids	NNP
cord-001835-0s7ok4uw	3396	2	formed	form	VBN
cord-001835-0s7ok4uw	3396	3	by	by	IN
cord-001835-0s7ok4uw	3396	4	BCAII	BCAII	NNS
cord-001835-0s7ok4uw	3396	5	were	be	VBD
cord-001835-0s7ok4uw	3396	6	unable	unable	JJ
cord-001835-0s7ok4uw	3396	7	to	to	TO
cord-001835-0s7ok4uw	3396	8	seed	seed	VB
cord-001835-0s7ok4uw	3396	9	the	the	DT
cord-001835-0s7ok4uw	3396	10	fibrillation	fibrillation	NN
cord-001835-0s7ok4uw	3396	11	of	of	IN
cord-001835-0s7ok4uw	3396	12	PepB	PepB	NNP
cord-001835-0s7ok4uw	3396	13	and	and	CC
cord-001835-0s7ok4uw	3396	14	vice	vice	NN
cord-001835-0s7ok4uw	3396	15	versa	versa	RB
cord-001835-0s7ok4uw	3396	16	.	.	.
cord-001835-0s7ok4uw	3397	1	Even	even	RB
cord-001835-0s7ok4uw	3397	2	the	the	DT
cord-001835-0s7ok4uw	3397	3	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	3397	4	formed	form	VBN
cord-001835-0s7ok4uw	3397	5	during	during	IN
cord-001835-0s7ok4uw	3397	6	lag	lag	NN
cord-001835-0s7ok4uw	3397	7	phase	phase	NN
cord-001835-0s7ok4uw	3397	8	revealed	reveal	VBD
cord-001835-0s7ok4uw	3397	9	contrasting	contrast	VBG
cord-001835-0s7ok4uw	3397	10	FTIR	FTIR	NNP
cord-001835-0s7ok4uw	3397	11	,	,	,
cord-001835-0s7ok4uw	3397	12	far	far	JJ
cord-001835-0s7ok4uw	3397	13	UV	uv	NN
cord-001835-0s7ok4uw	3397	14	CD	cd	NN
cord-001835-0s7ok4uw	3397	15	signature	signature	NN
cord-001835-0s7ok4uw	3397	16	,	,	,
cord-001835-0s7ok4uw	3397	17	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	3397	18	and	and	CC
cord-001835-0s7ok4uw	3397	19	morphology	morphology	NN
cord-001835-0s7ok4uw	3397	20	.	.	.
cord-001835-0s7ok4uw	3398	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3398	2	propose	propose	VBP
cord-001835-0s7ok4uw	3398	3	that	that	IN
cord-001835-0s7ok4uw	3398	4	for	for	IN
cord-001835-0s7ok4uw	3398	5	any	any	DT
cord-001835-0s7ok4uw	3398	6	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	3398	7	,	,	,
cord-001835-0s7ok4uw	3398	8	the	the	DT
cord-001835-0s7ok4uw	3398	9	sequences	sequence	NNS
cord-001835-0s7ok4uw	3398	10	flanking	flank	VBG
cord-001835-0s7ok4uw	3398	11	a	a	DT
cord-001835-0s7ok4uw	3398	12	critical	critical	JJ
cord-001835-0s7ok4uw	3398	13	region	region	NN
cord-001835-0s7ok4uw	3398	14	are	be	VBP
cord-001835-0s7ok4uw	3398	15	equally	equally	RB
cord-001835-0s7ok4uw	3398	16	effective	effective	JJ
cord-001835-0s7ok4uw	3398	17	in	in	IN
cord-001835-0s7ok4uw	3398	18	modulating	modulate	VBG
cord-001835-0s7ok4uw	3398	19	the	the	DT
cord-001835-0s7ok4uw	3398	20	initial	initial	JJ
cord-001835-0s7ok4uw	3398	21	nucleation	nucleation	NN
cord-001835-0s7ok4uw	3398	22	events	event	NNS
cord-001835-0s7ok4uw	3398	23	,	,	,
cord-001835-0s7ok4uw	3398	24	generating	generate	VBG
cord-001835-0s7ok4uw	3398	25	prefibrillar	prefibrillar	NNP
cord-001835-0s7ok4uw	3398	26	and	and	CC
cord-001835-0s7ok4uw	3398	27	finally	finally	RB
cord-001835-0s7ok4uw	3398	28	fibrillar	fibrillar	NNP
cord-001835-0s7ok4uw	3398	29	species	specie	NNS
cord-001835-0s7ok4uw	3398	30	with	with	IN
cord-001835-0s7ok4uw	3398	31	contrasting	contrast	VBG
cord-001835-0s7ok4uw	3398	32	characteristic	characteristic	NN
cord-001835-0s7ok4uw	3398	33	.	.	.
cord-001835-0s7ok4uw	3399	1	The	the	DT
cord-001835-0s7ok4uw	3399	2	results	result	NNS
cord-001835-0s7ok4uw	3399	3	have	have	VBP
cord-001835-0s7ok4uw	3399	4	been	be	VBN
cord-001835-0s7ok4uw	3399	5	discussed	discuss	VBN
cord-001835-0s7ok4uw	3399	6	in	in	IN
cord-001835-0s7ok4uw	3399	7	light	light	NN
cord-001835-0s7ok4uw	3399	8	of	of	IN
cord-001835-0s7ok4uw	3399	9	amyloid	amyloid	NN
cord-001835-0s7ok4uw	3399	10	polymorphism	polymorphism	NN
cord-001835-0s7ok4uw	3399	11	and	and	CC
cord-001835-0s7ok4uw	3399	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3399	13	importance	importance	NN
cord-001835-0s7ok4uw	3399	14	in	in	IN
cord-001835-0s7ok4uw	3399	15	the	the	DT
cord-001835-0s7ok4uw	3399	16	design	design	NN
cord-001835-0s7ok4uw	3399	17	of	of	IN
cord-001835-0s7ok4uw	3399	18	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	3399	19	strategies	strategy	NNS
cord-001835-0s7ok4uw	3399	20	targeting	target	VBG
cord-001835-0s7ok4uw	3399	21	such	such	JJ
cord-001835-0s7ok4uw	3399	22	toxic	toxic	JJ
cord-001835-0s7ok4uw	3399	23	regions	region	NNS
cord-001835-0s7ok4uw	3399	24	.	.	.
cord-001835-0s7ok4uw	3400	1	Aksana	Aksana	NNP
cord-001835-0s7ok4uw	3400	2	Labokha	Labokha	NNP
cord-001835-0s7ok4uw	3400	3	1	1	CD
cord-001835-0s7ok4uw	3400	4	,	,	,
cord-001835-0s7ok4uw	3400	5	Ralph	Ralph	NNP
cord-001835-0s7ok4uw	3400	6	Minter	Minter	NNP
cord-001835-0s7ok4uw	3400	7	1	1	CD
cord-001835-0s7ok4uw	3400	8	1	1	CD
cord-001835-0s7ok4uw	3401	1	All	all	DT
cord-001835-0s7ok4uw	3401	2	approved	approve	VBN
cord-001835-0s7ok4uw	3401	3	biological	biological	JJ
cord-001835-0s7ok4uw	3401	4	drugs	drug	NNS
cord-001835-0s7ok4uw	3401	5	target	target	VBP
cord-001835-0s7ok4uw	3401	6	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	3401	7	proteins	protein	NNS
cord-001835-0s7ok4uw	3401	8	and	and	CC
cord-001835-0s7ok4uw	3401	9	not	not	RB
cord-001835-0s7ok4uw	3401	10	the	the	DT
cord-001835-0s7ok4uw	3401	11	majority	majority	NN
cord-001835-0s7ok4uw	3401	12	of	of	IN
cord-001835-0s7ok4uw	3401	13	the	the	DT
cord-001835-0s7ok4uw	3401	14	expressed	express	VBN
cord-001835-0s7ok4uw	3401	15	human	human	JJ
cord-001835-0s7ok4uw	3401	16	genome	genome	NN
cord-001835-0s7ok4uw	3401	17	,	,	,
cord-001835-0s7ok4uw	3401	18	which	which	WDT
cord-001835-0s7ok4uw	3401	19	resides	reside	VBZ
cord-001835-0s7ok4uw	3401	20	within	within	IN
cord-001835-0s7ok4uw	3401	21	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3401	22	compartments	compartment	NNS
cord-001835-0s7ok4uw	3401	23	.	.	.
cord-001835-0s7ok4uw	3402	1	Included	include	VBN
cord-001835-0s7ok4uw	3402	2	in	in	IN
cord-001835-0s7ok4uw	3402	3	the	the	DT
cord-001835-0s7ok4uw	3402	4	latter	latter	JJ
cord-001835-0s7ok4uw	3402	5	category	category	NN
cord-001835-0s7ok4uw	3402	6	are	be	VBP
cord-001835-0s7ok4uw	3402	7	many	many	JJ
cord-001835-0s7ok4uw	3402	8	important	important	JJ
cord-001835-0s7ok4uw	3402	9	,	,	,
cord-001835-0s7ok4uw	3402	10	disease	disease	NN
cord-001835-0s7ok4uw	3402	11	-	-	HYPH
cord-001835-0s7ok4uw	3402	12	relevant	relevant	JJ
cord-001835-0s7ok4uw	3402	13	targets	target	NNS
cord-001835-0s7ok4uw	3402	14	which	which	WDT
cord-001835-0s7ok4uw	3402	15	can	can	MD
cord-001835-0s7ok4uw	3402	16	not	not	RB
cord-001835-0s7ok4uw	3402	17	be	be	VB
cord-001835-0s7ok4uw	3402	18	easily	easily	RB
cord-001835-0s7ok4uw	3402	19	addressed	address	VBN
cord-001835-0s7ok4uw	3402	20	by	by	IN
cord-001835-0s7ok4uw	3402	21	small	small	JJ
cord-001835-0s7ok4uw	3402	22	molecule	molecule	NN
cord-001835-0s7ok4uw	3402	23	approaches	approach	NNS
cord-001835-0s7ok4uw	3402	24	,	,	,
cord-001835-0s7ok4uw	3402	25	such	such	JJ
cord-001835-0s7ok4uw	3402	26	as	as	IN
cord-001835-0s7ok4uw	3402	27	the	the	DT
cord-001835-0s7ok4uw	3402	28	oncology	oncology	NN
cord-001835-0s7ok4uw	3402	29	targets	target	VBZ
cord-001835-0s7ok4uw	3402	30	c	c	NNP
cord-001835-0s7ok4uw	3402	31	-	-	:
cord-001835-0s7ok4uw	3402	32	Myc	Myc	NNP
cord-001835-0s7ok4uw	3402	33	and	and	CC
cord-001835-0s7ok4uw	3402	34	K	K	NNP
cord-001835-0s7ok4uw	3402	35	-	-	HYPH
cord-001835-0s7ok4uw	3402	36	Ras	Ras	NNP
cord-001835-0s7ok4uw	3402	37	.	.	.
cord-001835-0s7ok4uw	3403	1	Although	although	IN
cord-001835-0s7ok4uw	3403	2	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	3403	3	and	and	CC
cord-001835-0s7ok4uw	3403	4	viruses	virus	NNS
cord-001835-0s7ok4uw	3403	5	have	have	VBP
cord-001835-0s7ok4uw	3403	6	evolved	evolve	VBN
cord-001835-0s7ok4uw	3403	7	strategies	strategy	NNS
cord-001835-0s7ok4uw	3403	8	to	to	TO
cord-001835-0s7ok4uw	3403	9	deliver	deliver	VB
cord-001835-0s7ok4uw	3403	10	biological	biological	JJ
cord-001835-0s7ok4uw	3403	11	material	material	NN
cord-001835-0s7ok4uw	3403	12	to	to	IN
cord-001835-0s7ok4uw	3403	13	the	the	DT
cord-001835-0s7ok4uw	3403	14	cell	cell	NN
cord-001835-0s7ok4uw	3403	15	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	3403	16	and	and	CC
cord-001835-0s7ok4uw	3403	17	nucleus	nucleus	NN
cord-001835-0s7ok4uw	3403	18	,	,	,
cord-001835-0s7ok4uw	3403	19	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3403	20	ability	ability	NN
cord-001835-0s7ok4uw	3403	21	to	to	TO
cord-001835-0s7ok4uw	3403	22	engineer	engineer	VB
cord-001835-0s7ok4uw	3403	23	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	3403	24	proteins	protein	NNS
cord-001835-0s7ok4uw	3403	25	to	to	TO
cord-001835-0s7ok4uw	3403	26	replicate	replicate	VB
cord-001835-0s7ok4uw	3403	27	this	this	DT
cord-001835-0s7ok4uw	3403	28	is	be	VBZ
cord-001835-0s7ok4uw	3403	29	somewhat	somewhat	RB
cord-001835-0s7ok4uw	3403	30	limited	limit	VBN
cord-001835-0s7ok4uw	3403	31	by	by	IN
cord-001835-0s7ok4uw	3403	32	(	(	-LRB-
cord-001835-0s7ok4uw	3403	33	i	i	NN
cord-001835-0s7ok4uw	3403	34	)	)	-RRB-
cord-001835-0s7ok4uw	3404	1	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3404	2	nascent	nascent	JJ
cord-001835-0s7ok4uw	3404	3	understanding	understanding	NN
cord-001835-0s7ok4uw	3404	4	of	of	IN
cord-001835-0s7ok4uw	3404	5	protein	protein	NN
cord-001835-0s7ok4uw	3404	6	uptake	uptake	NN
cord-001835-0s7ok4uw	3404	7	and	and	CC
cord-001835-0s7ok4uw	3404	8	trafficking	traffic	VBG
cord-001835-0s7ok4uw	3404	9	pathways	pathway	NNS
cord-001835-0s7ok4uw	3404	10	and	and	CC
cord-001835-0s7ok4uw	3404	11	(	(	-LRB-
cord-001835-0s7ok4uw	3404	12	ii	ii	NN
cord-001835-0s7ok4uw	3404	13	)	)	-RRB-
cord-001835-0s7ok4uw	3404	14	the	the	DT
cord-001835-0s7ok4uw	3404	15	ability	ability	NN
cord-001835-0s7ok4uw	3404	16	to	to	TO
cord-001835-0s7ok4uw	3404	17	easily	easily	RB
cord-001835-0s7ok4uw	3404	18	quantify	quantify	VB
cord-001835-0s7ok4uw	3404	19	cell	cell	NN
cord-001835-0s7ok4uw	3404	20	delivery	delivery	NN
cord-001835-0s7ok4uw	3404	21	to	to	IN
cord-001835-0s7ok4uw	3404	22	the	the	DT
cord-001835-0s7ok4uw	3404	23	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	3404	24	and	and	CC
cord-001835-0s7ok4uw	3404	25	cellular	cellular	JJ
cord-001835-0s7ok4uw	3404	26	organelles	organelle	NNS
cord-001835-0s7ok4uw	3404	27	.	.	.
cord-001835-0s7ok4uw	3405	1	The	the	DT
cord-001835-0s7ok4uw	3405	2	aim	aim	NN
cord-001835-0s7ok4uw	3405	3	of	of	IN
cord-001835-0s7ok4uw	3405	4	my	-PRON-	PRP$
cord-001835-0s7ok4uw	3405	5	project	project	NN
cord-001835-0s7ok4uw	3405	6	is	be	VBZ
cord-001835-0s7ok4uw	3405	7	to	to	TO
cord-001835-0s7ok4uw	3405	8	address	address	VB
cord-001835-0s7ok4uw	3405	9	these	these	DT
cord-001835-0s7ok4uw	3405	10	challenges	challenge	NNS
cord-001835-0s7ok4uw	3405	11	by	by	IN
cord-001835-0s7ok4uw	3405	12	developing	develop	VBG
cord-001835-0s7ok4uw	3405	13	an	an	DT
cord-001835-0s7ok4uw	3405	14	effective	effective	JJ
cord-001835-0s7ok4uw	3405	15	assay	assay	NN
cord-001835-0s7ok4uw	3405	16	for	for	IN
cord-001835-0s7ok4uw	3405	17	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	3405	18	uptake	uptake	NN
cord-001835-0s7ok4uw	3405	19	and	and	CC
cord-001835-0s7ok4uw	3405	20	then	then	RB
cord-001835-0s7ok4uw	3405	21	using	use	VBG
cord-001835-0s7ok4uw	3405	22	it	-PRON-	PRP
cord-001835-0s7ok4uw	3405	23	to	to	TO
cord-001835-0s7ok4uw	3405	24	measure	measure	VB
cord-001835-0s7ok4uw	3405	25	the	the	DT
cord-001835-0s7ok4uw	3405	26	delivery	delivery	NN
cord-001835-0s7ok4uw	3405	27	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3405	28	of	of	IN
cord-001835-0s7ok4uw	3405	29	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	3405	30	proteins	protein	NNS
cord-001835-0s7ok4uw	3405	31	which	which	WDT
cord-001835-0s7ok4uw	3405	32	mimic	mimic	VBP
cord-001835-0s7ok4uw	3405	33	natural	natural	JJ
cord-001835-0s7ok4uw	3405	34	delivery	delivery	NN
cord-001835-0s7ok4uw	3405	35	strategies	strategy	NNS
cord-001835-0s7ok4uw	3405	36	e.g.	e.g.	IN
cord-001835-0s7ok4uw	3405	37	cell	cell	NN
cord-001835-0s7ok4uw	3405	38	penetrating	penetrate	VBG
cord-001835-0s7ok4uw	3405	39	peptides	peptide	NNS
cord-001835-0s7ok4uw	3405	40	fusion	fusion	NN
cord-001835-0s7ok4uw	3405	41	,	,	,
cord-001835-0s7ok4uw	3405	42	exotoxin	exotoxin	NN
cord-001835-0s7ok4uw	3405	43	mimics	mimic	VBZ
cord-001835-0s7ok4uw	3405	44	,	,	,
cord-001835-0s7ok4uw	3405	45	and	and	CC
cord-001835-0s7ok4uw	3405	46	supercharged	supercharged	JJ
cord-001835-0s7ok4uw	3405	47	proteins	protein	NNS
cord-001835-0s7ok4uw	3405	48	(	(	-LRB-
cord-001835-0s7ok4uw	3405	49	proteins	protein	NNS
cord-001835-0s7ok4uw	3405	50	with	with	IN
cord-001835-0s7ok4uw	3405	51	high	high	JJ
cord-001835-0s7ok4uw	3405	52	surface	surface	NN
cord-001835-0s7ok4uw	3405	53	charge	charge	NN
cord-001835-0s7ok4uw	3405	54	which	which	WDT
cord-001835-0s7ok4uw	3405	55	can	can	MD
cord-001835-0s7ok4uw	3405	56	enter	enter	VB
cord-001835-0s7ok4uw	3405	57	cells	cell	NNS
cord-001835-0s7ok4uw	3405	58	)	)	-RRB-
cord-001835-0s7ok4uw	3405	59	.	.	.
cord-001835-0s7ok4uw	3406	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	3406	2	also	also	RB
cord-001835-0s7ok4uw	3406	3	intend	intend	VBP
cord-001835-0s7ok4uw	3406	4	to	to	TO
cord-001835-0s7ok4uw	3406	5	explore	explore	VB
cord-001835-0s7ok4uw	3406	6	the	the	DT
cord-001835-0s7ok4uw	3406	7	influence	influence	NN
cord-001835-0s7ok4uw	3406	8	of	of	IN
cord-001835-0s7ok4uw	3406	9	the	the	DT
cord-001835-0s7ok4uw	3406	10	Rab	Rab	NNP
cord-001835-0s7ok4uw	3406	11	superfamily	superfamily	NN
cord-001835-0s7ok4uw	3406	12	,	,	,
cord-001835-0s7ok4uw	3406	13	which	which	WDT
cord-001835-0s7ok4uw	3406	14	are	be	VBP
cord-001835-0s7ok4uw	3406	15	the	the	DT
cord-001835-0s7ok4uw	3406	16	master	master	NN
cord-001835-0s7ok4uw	3406	17	regulators	regulator	NNS
cord-001835-0s7ok4uw	3406	18	of	of	IN
cord-001835-0s7ok4uw	3406	19	protein	protein	NN
cord-001835-0s7ok4uw	3406	20	trafficking	trafficking	NN
cord-001835-0s7ok4uw	3406	21	,	,	,
cord-001835-0s7ok4uw	3406	22	to	to	TO
cord-001835-0s7ok4uw	3406	23	influence	influence	VB
cord-001835-0s7ok4uw	3406	24	and	and	CC
cord-001835-0s7ok4uw	3406	25	control	control	VB
cord-001835-0s7ok4uw	3406	26	both	both	CC
cord-001835-0s7ok4uw	3406	27	the	the	DT
cord-001835-0s7ok4uw	3406	28	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	3406	29	and	and	CC
cord-001835-0s7ok4uw	3406	30	final	final	JJ
cord-001835-0s7ok4uw	3406	31	subcellular	subcellular	JJ
cord-001835-0s7ok4uw	3406	32	destination	destination	NN
cord-001835-0s7ok4uw	3406	33	of	of	IN
cord-001835-0s7ok4uw	3406	34	exogenous	exogenous	JJ
cord-001835-0s7ok4uw	3406	35	proteins	protein	NNS
cord-001835-0s7ok4uw	3406	36	.	.	.
cord-001835-0s7ok4uw	3407	1	Protein	protein	NN
cord-001835-0s7ok4uw	3407	2	engineering	engineering	NN
cord-001835-0s7ok4uw	3407	3	:	:	:
cord-001835-0s7ok4uw	3407	4	what	what	WP
cord-001835-0s7ok4uw	3407	5	's	be	VBZ
cord-001835-0s7ok4uw	3407	6	next	next	JJ
cord-001835-0s7ok4uw	3407	7	?	?	.
cord-001835-0s7ok4uw	3408	1	With	with	IN
cord-001835-0s7ok4uw	3408	2	the	the	DT
cord-001835-0s7ok4uw	3408	3	growing	grow	VBG
cord-001835-0s7ok4uw	3408	4	industrial	industrial	JJ
cord-001835-0s7ok4uw	3408	5	need	need	NN
cord-001835-0s7ok4uw	3408	6	for	for	IN
cord-001835-0s7ok4uw	3408	7	engineering	engineering	NN
cord-001835-0s7ok4uw	3408	8	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3408	9	for	for	IN
cord-001835-0s7ok4uw	3408	10	the	the	DT
cord-001835-0s7ok4uw	3408	11	deconstruction	deconstruction	NN
cord-001835-0s7ok4uw	3408	12	and	and	CC
cord-001835-0s7ok4uw	3408	13	transformation	transformation	NN
cord-001835-0s7ok4uw	3408	14	of	of	IN
cord-001835-0s7ok4uw	3408	15	plant	plant	NN
cord-001835-0s7ok4uw	3408	16	biomass	biomass	NN
cord-001835-0s7ok4uw	3408	17	in	in	IN
cord-001835-0s7ok4uw	3408	18	biorefineries	biorefinerie	NNS
cord-001835-0s7ok4uw	3408	19	,	,	,
cord-001835-0s7ok4uw	3408	20	there	there	EX
cord-001835-0s7ok4uw	3408	21	is	be	VBZ
cord-001835-0s7ok4uw	3408	22	a	a	DT
cord-001835-0s7ok4uw	3408	23	want	want	NN
cord-001835-0s7ok4uw	3408	24	for	for	IN
cord-001835-0s7ok4uw	3408	25	the	the	DT
cord-001835-0s7ok4uw	3408	26	development	development	NN
cord-001835-0s7ok4uw	3408	27	of	of	IN
cord-001835-0s7ok4uw	3408	28	new	new	JJ
cord-001835-0s7ok4uw	3408	29	approaches	approach	NNS
cord-001835-0s7ok4uw	3408	30	for	for	IN
cord-001835-0s7ok4uw	3408	31	designing	design	VBG
cord-001835-0s7ok4uw	3408	32	special	special	JJ
cord-001835-0s7ok4uw	3408	33	purpose	purpose	NN
cord-001835-0s7ok4uw	3408	34	biocatalysts	biocatalyst	NNS
cord-001835-0s7ok4uw	3408	35	.	.	.
cord-001835-0s7ok4uw	3409	1	Techniques	technique	NNS
cord-001835-0s7ok4uw	3409	2	,	,	,
cord-001835-0s7ok4uw	3409	3	such	such	JJ
cord-001835-0s7ok4uw	3409	4	as	as	IN
cord-001835-0s7ok4uw	3409	5	directed	direct	VBN
cord-001835-0s7ok4uw	3409	6	evolution	evolution	NN
cord-001835-0s7ok4uw	3409	7	,	,	,
cord-001835-0s7ok4uw	3409	8	which	which	WDT
cord-001835-0s7ok4uw	3409	9	mimic	mimic	VBP
cord-001835-0s7ok4uw	3409	10	the	the	DT
cord-001835-0s7ok4uw	3409	11	natural	natural	JJ
cord-001835-0s7ok4uw	3409	12	selection	selection	NN
cord-001835-0s7ok4uw	3409	13	process	process	NN
cord-001835-0s7ok4uw	3409	14	by	by	IN
cord-001835-0s7ok4uw	3409	15	evolving	evolve	VBG
cord-001835-0s7ok4uw	3409	16	proteins	protein	NNS
cord-001835-0s7ok4uw	3409	17	towards	towards	IN
cord-001835-0s7ok4uw	3409	18	the	the	DT
cord-001835-0s7ok4uw	3409	19	improvement	improvement	NN
cord-001835-0s7ok4uw	3409	20	of	of	IN
cord-001835-0s7ok4uw	3409	21	a	a	DT
cord-001835-0s7ok4uw	3409	22	given	give	VBN
cord-001835-0s7ok4uw	3409	23	property	property	NN
cord-001835-0s7ok4uw	3409	24	,	,	,
cord-001835-0s7ok4uw	3409	25	have	have	VBP
cord-001835-0s7ok4uw	3409	26	unquestionably	unquestionably	RB
cord-001835-0s7ok4uw	3409	27	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	3409	28	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3409	29	value	value	NN
cord-001835-0s7ok4uw	3409	30	and	and	CC
cord-001835-0s7ok4uw	3409	31	are	be	VBP
cord-001835-0s7ok4uw	3409	32	routinely	routinely	RB
cord-001835-0s7ok4uw	3409	33	used	use	VBN
cord-001835-0s7ok4uw	3409	34	in	in	IN
cord-001835-0s7ok4uw	3409	35	large	large	JJ
cord-001835-0s7ok4uw	3409	36	industrial	industrial	JJ
cord-001835-0s7ok4uw	3409	37	companies	company	NNS
cord-001835-0s7ok4uw	3409	38	.	.	.
cord-001835-0s7ok4uw	3410	1	Nevertheless	nevertheless	RB
cord-001835-0s7ok4uw	3410	2	,	,	,
cord-001835-0s7ok4uw	3410	3	the	the	DT
cord-001835-0s7ok4uw	3410	4	brute	brute	JJ
cord-001835-0s7ok4uw	3410	5	force	force	NN
cord-001835-0s7ok4uw	3410	6	employed	employ	VBN
cord-001835-0s7ok4uw	3410	7	in	in	IN
cord-001835-0s7ok4uw	3410	8	these	these	DT
cord-001835-0s7ok4uw	3410	9	methods	method	NNS
cord-001835-0s7ok4uw	3410	10	,	,	,
cord-001835-0s7ok4uw	3410	11	could	could	MD
cord-001835-0s7ok4uw	3410	12	significantly	significantly	RB
cord-001835-0s7ok4uw	3410	13	gain	gain	VB
cord-001835-0s7ok4uw	3410	14	from	from	IN
cord-001835-0s7ok4uw	3410	15	an	an	DT
cord-001835-0s7ok4uw	3410	16	all	all	DT
cord-001835-0s7ok4uw	3410	17	-	-	HYPH
cord-001835-0s7ok4uw	3410	18	atom	atom	NN
cord-001835-0s7ok4uw	3410	19	description	description	NN
cord-001835-0s7ok4uw	3410	20	of	of	IN
cord-001835-0s7ok4uw	3410	21	the	the	DT
cord-001835-0s7ok4uw	3410	22	underlying	underlying	JJ
cord-001835-0s7ok4uw	3410	23	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3410	24	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	3410	25	,	,	,
cord-001835-0s7ok4uw	3410	26	to	to	TO
cord-001835-0s7ok4uw	3410	27	center	center	VB
cord-001835-0s7ok4uw	3410	28	the	the	DT
cord-001835-0s7ok4uw	3410	29	efforts	effort	NNS
cord-001835-0s7ok4uw	3410	30	on	on	IN
cord-001835-0s7ok4uw	3410	31	more	more	JJR
cord-001835-0s7ok4uw	3410	32	limited	limited	JJ
cord-001835-0s7ok4uw	3410	33	areas	area	NNS
cord-001835-0s7ok4uw	3410	34	of	of	IN
cord-001835-0s7ok4uw	3410	35	the	the	DT
cord-001835-0s7ok4uw	3410	36	protein	protein	NN
cord-001835-0s7ok4uw	3410	37	.	.	.
cord-001835-0s7ok4uw	3411	1	In	in	IN
cord-001835-0s7ok4uw	3411	2	the	the	DT
cord-001835-0s7ok4uw	3411	3	last	last	JJ
cord-001835-0s7ok4uw	3411	4	years	year	NNS
cord-001835-0s7ok4uw	3411	5	,	,	,
cord-001835-0s7ok4uw	3411	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	3411	7	have	have	VBP
cord-001835-0s7ok4uw	3411	8	developed	develop	VBN
cord-001835-0s7ok4uw	3411	9	computational	computational	JJ
cord-001835-0s7ok4uw	3411	10	tools	tool	NNS
cord-001835-0s7ok4uw	3411	11	,	,	,
cord-001835-0s7ok4uw	3411	12	which	which	WDT
cord-001835-0s7ok4uw	3411	13	combine	combine	VBP
cord-001835-0s7ok4uw	3411	14	the	the	DT
cord-001835-0s7ok4uw	3411	15	electronic	electronic	JJ
cord-001835-0s7ok4uw	3411	16	structure	structure	NN
cord-001835-0s7ok4uw	3411	17	description	description	NN
cord-001835-0s7ok4uw	3411	18	of	of	IN
cord-001835-0s7ok4uw	3411	19	QM	QM	NNP
cord-001835-0s7ok4uw	3411	20	/	/	SYM
cord-001835-0s7ok4uw	3411	21	MM	MM	NNP
cord-001835-0s7ok4uw	3411	22	methods	method	NNS
cord-001835-0s7ok4uw	3411	23	with	with	IN
cord-001835-0s7ok4uw	3411	24	the	the	DT
cord-001835-0s7ok4uw	3411	25	potential	potential	NN
cord-001835-0s7ok4uw	3411	26	to	to	TO
cord-001835-0s7ok4uw	3411	27	model	model	VB
cord-001835-0s7ok4uw	3411	28	long	long	JJ
cord-001835-0s7ok4uw	3411	29	time	time	NN
cord-001835-0s7ok4uw	3411	30	scale	scale	NN
cord-001835-0s7ok4uw	3411	31	processes	process	NNS
cord-001835-0s7ok4uw	3411	32	of	of	IN
cord-001835-0s7ok4uw	3411	33	PELE,1	pele,1	NN
cord-001835-0s7ok4uw	3411	34	to	to	TO
cord-001835-0s7ok4uw	3411	35	study	study	VB
cord-001835-0s7ok4uw	3411	36	the	the	DT
cord-001835-0s7ok4uw	3411	37	details	detail	NNS
cord-001835-0s7ok4uw	3411	38	of	of	IN
cord-001835-0s7ok4uw	3411	39	a	a	DT
cord-001835-0s7ok4uw	3411	40	variety	variety	NN
cord-001835-0s7ok4uw	3411	41	of	of	IN
cord-001835-0s7ok4uw	3411	42	reactions	reaction	NNS
cord-001835-0s7ok4uw	3411	43	.	.	.
cord-001835-0s7ok4uw	3412	1	Examples	example	NNS
cord-001835-0s7ok4uw	3412	2	,	,	,
cord-001835-0s7ok4uw	3412	3	which	which	WDT
cord-001835-0s7ok4uw	3412	4	will	will	MD
cord-001835-0s7ok4uw	3412	5	be	be	VB
cord-001835-0s7ok4uw	3412	6	discussed	discuss	VBN
cord-001835-0s7ok4uw	3412	7	,	,	,
cord-001835-0s7ok4uw	3412	8	include	include	VBP
cord-001835-0s7ok4uw	3412	9	rationalizing	rationalize	VBG
cord-001835-0s7ok4uw	3412	10	the	the	DT
cord-001835-0s7ok4uw	3412	11	selective	selective	JJ
cord-001835-0s7ok4uw	3412	12	oxyfunctionalization	oxyfunctionalization	NN
cord-001835-0s7ok4uw	3412	13	of	of	IN
cord-001835-0s7ok4uw	3412	14	steroids	steroid	NNS
cord-001835-0s7ok4uw	3412	15	using	use	VBG
cord-001835-0s7ok4uw	3412	16	fungal	fungal	JJ
cord-001835-0s7ok4uw	3412	17	enzymes2	enzymes2	NN
cord-001835-0s7ok4uw	3412	18	and	and	CC
cord-001835-0s7ok4uw	3412	19	the	the	DT
cord-001835-0s7ok4uw	3412	20	study	study	NN
cord-001835-0s7ok4uw	3412	21	of	of	IN
cord-001835-0s7ok4uw	3412	22	the	the	DT
cord-001835-0s7ok4uw	3412	23	effect	effect	NN
cord-001835-0s7ok4uw	3412	24	of	of	IN
cord-001835-0s7ok4uw	3412	25	point	point	NN
cord-001835-0s7ok4uw	3412	26	mutations	mutation	NNS
cord-001835-0s7ok4uw	3412	27	on	on	IN
cord-001835-0s7ok4uw	3412	28	the	the	DT
cord-001835-0s7ok4uw	3412	29	oxidation	oxidation	NN
cord-001835-0s7ok4uw	3412	30	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3412	31	of	of	IN
cord-001835-0s7ok4uw	3412	32	laccases.3	laccases.3	NN
cord-001835-0s7ok4uw	3413	1	These	these	DT
cord-001835-0s7ok4uw	3413	2	methods	method	NNS
cord-001835-0s7ok4uw	3413	3	have	have	VBP
cord-001835-0s7ok4uw	3413	4	shown	show	VBN
cord-001835-0s7ok4uw	3413	5	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3413	6	potential	potential	NN
cord-001835-0s7ok4uw	3413	7	not	not	RB
cord-001835-0s7ok4uw	3413	8	only	only	RB
cord-001835-0s7ok4uw	3413	9	at	at	IN
cord-001835-0s7ok4uw	3413	10	the	the	DT
cord-001835-0s7ok4uw	3413	11	descriptive	descriptive	JJ
cord-001835-0s7ok4uw	3413	12	level	level	NN
cord-001835-0s7ok4uw	3413	13	but	but	CC
cord-001835-0s7ok4uw	3413	14	,	,	,
cord-001835-0s7ok4uw	3413	15	more	more	RBR
cord-001835-0s7ok4uw	3413	16	importantly	importantly	RB
cord-001835-0s7ok4uw	3413	17	,	,	,
cord-001835-0s7ok4uw	3413	18	through	through	IN
cord-001835-0s7ok4uw	3413	19	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3413	20	high	high	JJ
cord-001835-0s7ok4uw	3413	21	predictive	predictive	JJ
cord-001835-0s7ok4uw	3413	22	capability	capability	NN
cord-001835-0s7ok4uw	3413	23	that	that	WDT
cord-001835-0s7ok4uw	3413	24	opens	open	VBZ
cord-001835-0s7ok4uw	3413	25	many	many	JJ
cord-001835-0s7ok4uw	3413	26	opportunities	opportunity	NNS
cord-001835-0s7ok4uw	3413	27	for	for	IN
cord-001835-0s7ok4uw	3413	28	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3413	29	use	use	NN
cord-001835-0s7ok4uw	3413	30	in	in	IN
cord-001835-0s7ok4uw	3413	31	biotechnology	biotechnology	NN
cord-001835-0s7ok4uw	3413	32	.	.	.
cord-001835-0s7ok4uw	3414	1	In	in	IN
cord-001835-0s7ok4uw	3414	2	this	this	DT
cord-001835-0s7ok4uw	3414	3	talk	talk	NN
cord-001835-0s7ok4uw	3414	4	,	,	,
cord-001835-0s7ok4uw	3414	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3414	6	will	will	MD
cord-001835-0s7ok4uw	3414	7	show	show	VB
cord-001835-0s7ok4uw	3414	8	how	how	WRB
cord-001835-0s7ok4uw	3414	9	recent	recent	JJ
cord-001835-0s7ok4uw	3414	10	advances	advance	NNS
cord-001835-0s7ok4uw	3414	11	in	in	IN
cord-001835-0s7ok4uw	3414	12	in	in	IN
cord-001835-0s7ok4uw	3414	13	silico	silico	NN
cord-001835-0s7ok4uw	3414	14	approaches	approach	NNS
cord-001835-0s7ok4uw	3414	15	are	be	VBP
cord-001835-0s7ok4uw	3414	16	setting	set	VBG
cord-001835-0s7ok4uw	3414	17	new	new	JJ
cord-001835-0s7ok4uw	3414	18	grounds	ground	NNS
cord-001835-0s7ok4uw	3414	19	for	for	IN
cord-001835-0s7ok4uw	3414	20	future	future	JJ
cord-001835-0s7ok4uw	3414	21	computer	computer	NN
cord-001835-0s7ok4uw	3414	22	guided	guide	VBN
cord-001835-0s7ok4uw	3414	23	directed	direct	VBN
cord-001835-0s7ok4uw	3414	24	evolution	evolution	NN
cord-001835-0s7ok4uw	3414	25	.	.	.
cord-001835-0s7ok4uw	3414	26	 	 	_SP
cord-001835-0s7ok4uw	3415	1	Several	several	JJ
cord-001835-0s7ok4uw	3415	2	orthogonal	orthogonal	JJ
cord-001835-0s7ok4uw	3415	3	bioreactions	bioreaction	NNS
cord-001835-0s7ok4uw	3415	4	take	take	VBP
cord-001835-0s7ok4uw	3415	5	place	place	NN
cord-001835-0s7ok4uw	3415	6	simultaneously	simultaneously	RB
cord-001835-0s7ok4uw	3415	7	within	within	IN
cord-001835-0s7ok4uw	3415	8	membrane	membrane	NN
cord-001835-0s7ok4uw	3415	9	bound	bind	VBN
cord-001835-0s7ok4uw	3415	10	organelles	organelle	NNS
cord-001835-0s7ok4uw	3415	11	in	in	IN
cord-001835-0s7ok4uw	3415	12	eukaryotes	eukaryote	NNS
cord-001835-0s7ok4uw	3415	13	and	and	CC
cord-001835-0s7ok4uw	3415	14	proteinaceous	proteinaceous	JJ
cord-001835-0s7ok4uw	3415	15	microcompartments	microcompartment	NNS
cord-001835-0s7ok4uw	3415	16	in	in	IN
cord-001835-0s7ok4uw	3415	17	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	3415	18	.	.	.
cord-001835-0s7ok4uw	3416	1	These	these	DT
cord-001835-0s7ok4uw	3416	2	subcellular	subcellular	JJ
cord-001835-0s7ok4uw	3416	3	structures	structure	NNS
cord-001835-0s7ok4uw	3416	4	contain	contain	VBP
cord-001835-0s7ok4uw	3416	5	sets	set	NNS
cord-001835-0s7ok4uw	3416	6	of	of	IN
cord-001835-0s7ok4uw	3416	7	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3416	8	co	co	VBP
cord-001835-0s7ok4uw	3416	9	-	-	NNS
cord-001835-0s7ok4uw	3416	10	involved	involved	JJ
cord-001835-0s7ok4uw	3416	11	in	in	IN
cord-001835-0s7ok4uw	3416	12	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	3416	13	pathways	pathway	NNS
cord-001835-0s7ok4uw	3416	14	.	.	.
cord-001835-0s7ok4uw	3417	1	Towards	towards	IN
cord-001835-0s7ok4uw	3417	2	the	the	DT
cord-001835-0s7ok4uw	3417	3	goal	goal	NN
cord-001835-0s7ok4uw	3417	4	of	of	IN
cord-001835-0s7ok4uw	3417	5	creating	create	VBG
cord-001835-0s7ok4uw	3417	6	artificial	artificial	JJ
cord-001835-0s7ok4uw	3417	7	protein	protein	NN
cord-001835-0s7ok4uw	3417	8	microreactors	microreactor	NNS
cord-001835-0s7ok4uw	3417	9	,	,	,
cord-001835-0s7ok4uw	3417	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	3417	11	seek	seek	VBP
cord-001835-0s7ok4uw	3417	12	to	to	TO
cord-001835-0s7ok4uw	3417	13	develop	develop	VB
cord-001835-0s7ok4uw	3417	14	an	an	DT
cord-001835-0s7ok4uw	3417	15	artificial	artificial	JJ
cord-001835-0s7ok4uw	3417	16	organelle	organelle	NN
cord-001835-0s7ok4uw	3417	17	that	that	WDT
cord-001835-0s7ok4uw	3417	18	emulates	emulate	VBZ
cord-001835-0s7ok4uw	3417	19	the	the	DT
cord-001835-0s7ok4uw	3417	20	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	3417	21	activity	activity	NN
cord-001835-0s7ok4uw	3417	22	of	of	IN
cord-001835-0s7ok4uw	3417	23	the	the	DT
cord-001835-0s7ok4uw	3417	24	carbon	carbon	NN
cord-001835-0s7ok4uw	3417	25	fixating	fixate	VBG
cord-001835-0s7ok4uw	3417	26	organelle	organelle	NN
cord-001835-0s7ok4uw	3417	27	of	of	IN
cord-001835-0s7ok4uw	3417	28	autotrophic	autotrophic	JJ
cord-001835-0s7ok4uw	3417	29	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	3417	30	,	,	,
cord-001835-0s7ok4uw	3417	31	the	the	DT
cord-001835-0s7ok4uw	3417	32	carboxysome	carboxysome	NN
cord-001835-0s7ok4uw	3417	33	.	.	.
cord-001835-0s7ok4uw	3418	1	Here	here	RB
cord-001835-0s7ok4uw	3418	2	,	,	,
cord-001835-0s7ok4uw	3418	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3418	4	show	show	VBP
cord-001835-0s7ok4uw	3418	5	that	that	IN
cord-001835-0s7ok4uw	3418	6	the	the	DT
cord-001835-0s7ok4uw	3418	7	two	two	CD
cord-001835-0s7ok4uw	3418	8	key	key	JJ
cord-001835-0s7ok4uw	3418	9	carboxysomal	carboxysomal	NNP
cord-001835-0s7ok4uw	3418	10	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3418	11	,	,	,
cord-001835-0s7ok4uw	3418	12	ribulose-1,5-bisphosphate	ribulose-1,5-bisphosphate	NN
cord-001835-0s7ok4uw	3418	13	carboxylase	carboxylase	NN
cord-001835-0s7ok4uw	3418	14	/	/	SYM
cord-001835-0s7ok4uw	3418	15	oxygenase	oxygenase	NN
cord-001835-0s7ok4uw	3418	16	(	(	-LRB-
cord-001835-0s7ok4uw	3418	17	RuBisCO	rubisco	NN
cord-001835-0s7ok4uw	3418	18	)	)	-RRB-
cord-001835-0s7ok4uw	3418	19	and	and	CC
cord-001835-0s7ok4uw	3418	20	carbonic	carbonic	JJ
cord-001835-0s7ok4uw	3418	21	anhydrase	anhydrase	NN
cord-001835-0s7ok4uw	3418	22	(	(	-LRB-
cord-001835-0s7ok4uw	3418	23	CA	CA	NNP
cord-001835-0s7ok4uw	3418	24	)	)	-RRB-
cord-001835-0s7ok4uw	3418	25	,	,	,
cord-001835-0s7ok4uw	3418	26	can	can	MD
cord-001835-0s7ok4uw	3418	27	be	be	VB
cord-001835-0s7ok4uw	3418	28	efficiently	efficiently	RB
cord-001835-0s7ok4uw	3418	29	co	co	VBN
cord-001835-0s7ok4uw	3418	30	-	-	JJ
cord-001835-0s7ok4uw	3418	31	encapsulated	encapsulate	VBN
cord-001835-0s7ok4uw	3418	32	using	use	VBG
cord-001835-0s7ok4uw	3418	33	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3418	34	previously	previously	RB
cord-001835-0s7ok4uw	3418	35	reported	report	VBN
cord-001835-0s7ok4uw	3418	36	encapsulation	encapsulation	NN
cord-001835-0s7ok4uw	3418	37	system	system	NN
cord-001835-0s7ok4uw	3418	38	which	which	WDT
cord-001835-0s7ok4uw	3418	39	is	be	VBZ
cord-001835-0s7ok4uw	3418	40	based	base	VBN
cord-001835-0s7ok4uw	3418	41	on	on	IN
cord-001835-0s7ok4uw	3418	42	a	a	DT
cord-001835-0s7ok4uw	3418	43	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	3418	44	capsid	capsid	NN
cord-001835-0s7ok4uw	3418	45	formed	form	VBN
cord-001835-0s7ok4uw	3418	46	from	from	IN
cord-001835-0s7ok4uw	3418	47	the	the	DT
cord-001835-0s7ok4uw	3418	48	protein	protein	NN
cord-001835-0s7ok4uw	3418	49	lumazine	lumazine	NNP
cord-001835-0s7ok4uw	3418	50	synthase	synthase	NNP
cord-001835-0s7ok4uw	3418	51	(	(	-LRB-
cord-001835-0s7ok4uw	3418	52	AaLS-13	AaLS-13	NNP
cord-001835-0s7ok4uw	3418	53	)	)	-RRB-
cord-001835-0s7ok4uw	3418	54	.	.	.
cord-001835-0s7ok4uw	3419	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3419	2	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	3419	3	results	result	NNS
cord-001835-0s7ok4uw	3419	4	suggest	suggest	VBP
cord-001835-0s7ok4uw	3419	5	that	that	IN
cord-001835-0s7ok4uw	3419	6	the	the	DT
cord-001835-0s7ok4uw	3419	7	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3419	8	can	can	MD
cord-001835-0s7ok4uw	3419	9	act	act	VB
cord-001835-0s7ok4uw	3419	10	in	in	IN
cord-001835-0s7ok4uw	3419	11	tandem	tandem	NN
cord-001835-0s7ok4uw	3419	12	and	and	CC
cord-001835-0s7ok4uw	3419	13	that	that	IN
cord-001835-0s7ok4uw	3419	14	the	the	DT
cord-001835-0s7ok4uw	3419	15	co	co	NN
cord-001835-0s7ok4uw	3419	16	-	-	NN
cord-001835-0s7ok4uw	3419	17	encapsulation	encapsulation	NN
cord-001835-0s7ok4uw	3419	18	of	of	IN
cord-001835-0s7ok4uw	3419	19	CA	CA	NNP
cord-001835-0s7ok4uw	3419	20	with	with	IN
cord-001835-0s7ok4uw	3419	21	RuBisCO	rubisco	CD
cord-001835-0s7ok4uw	3419	22	in	in	IN
cord-001835-0s7ok4uw	3419	23	the	the	DT
cord-001835-0s7ok4uw	3419	24	capsid	capsid	NN
cord-001835-0s7ok4uw	3419	25	is	be	VBZ
cord-001835-0s7ok4uw	3419	26	necessary	necessary	JJ
cord-001835-0s7ok4uw	3419	27	for	for	IN
cord-001835-0s7ok4uw	3419	28	enhanced	enhance	VBN
cord-001835-0s7ok4uw	3419	29	RuBisCO	RuBisCO	:
cord-001835-0s7ok4uw	3419	30	activity	activity	NN
cord-001835-0s7ok4uw	3419	31	in	in	IN
cord-001835-0s7ok4uw	3419	32	vitro	vitro	FW
cord-001835-0s7ok4uw	3419	33	.	.	.
cord-001835-0s7ok4uw	3420	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3420	2	attribute	attribute	VBP
cord-001835-0s7ok4uw	3420	3	this	this	DT
cord-001835-0s7ok4uw	3420	4	observation	observation	NN
cord-001835-0s7ok4uw	3420	5	to	to	IN
cord-001835-0s7ok4uw	3420	6	the	the	DT
cord-001835-0s7ok4uw	3420	7	high	high	JJ
cord-001835-0s7ok4uw	3420	8	local	local	JJ
cord-001835-0s7ok4uw	3420	9	concentrations	concentration	NNS
cord-001835-0s7ok4uw	3420	10	of	of	IN
cord-001835-0s7ok4uw	3420	11	the	the	DT
cord-001835-0s7ok4uw	3420	12	RuBisCO	rubisco	CD
cord-001835-0s7ok4uw	3420	13	substrate	substrate	NN
cord-001835-0s7ok4uw	3420	14	,	,	,
cord-001835-0s7ok4uw	3420	15	CO2	CO2	NNP
cord-001835-0s7ok4uw	3420	16	,	,	,
cord-001835-0s7ok4uw	3420	17	produced	produce	VBN
cord-001835-0s7ok4uw	3420	18	by	by	IN
cord-001835-0s7ok4uw	3420	19	CA	CA	NNP
cord-001835-0s7ok4uw	3420	20	within	within	IN
cord-001835-0s7ok4uw	3420	21	the	the	DT
cord-001835-0s7ok4uw	3420	22	capsid	capsid	NN
cord-001835-0s7ok4uw	3420	23	.	.	.
cord-001835-0s7ok4uw	3421	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3421	2	are	be	VBP
cord-001835-0s7ok4uw	3421	3	developing	develop	VBG
cord-001835-0s7ok4uw	3421	4	a	a	DT
cord-001835-0s7ok4uw	3421	5	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	3421	6	model	model	NN
cord-001835-0s7ok4uw	3421	7	of	of	IN
cord-001835-0s7ok4uw	3421	8	a	a	DT
cord-001835-0s7ok4uw	3421	9	minimal	minimal	JJ
cord-001835-0s7ok4uw	3421	10	carboxysome	carboxysome	NN
cord-001835-0s7ok4uw	3421	11	using	use	VBG
cord-001835-0s7ok4uw	3421	12	the	the	DT
cord-001835-0s7ok4uw	3421	13	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	3421	14	rate	rate	NN
cord-001835-0s7ok4uw	3421	15	constants	constant	NNS
cord-001835-0s7ok4uw	3421	16	of	of	IN
cord-001835-0s7ok4uw	3421	17	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3421	18	RuBisCO	RuBisCO	NNS
cord-001835-0s7ok4uw	3421	19	and	and	CC
cord-001835-0s7ok4uw	3421	20	CA	CA	NNP
cord-001835-0s7ok4uw	3421	21	variants	variant	NNS
cord-001835-0s7ok4uw	3421	22	and	and	CC
cord-001835-0s7ok4uw	3421	23	AaLS-13	aals-13	CD
cord-001835-0s7ok4uw	3421	24	as	as	IN
cord-001835-0s7ok4uw	3421	25	the	the	DT
cord-001835-0s7ok4uw	3421	26	shell	shell	NN
cord-001835-0s7ok4uw	3421	27	to	to	TO
cord-001835-0s7ok4uw	3421	28	complement	complement	VB
cord-001835-0s7ok4uw	3421	29	these	these	DT
cord-001835-0s7ok4uw	3421	30	experiments	experiment	NNS
cord-001835-0s7ok4uw	3421	31	.	.	.
cord-001835-0s7ok4uw	3422	1	Next	next	RB
cord-001835-0s7ok4uw	3422	2	,	,	,
cord-001835-0s7ok4uw	3422	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3422	4	will	will	MD
cord-001835-0s7ok4uw	3422	5	incorporate	incorporate	VB
cord-001835-0s7ok4uw	3422	6	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3422	7	minimal	minimal	JJ
cord-001835-0s7ok4uw	3422	8	carboxysome	carboxysome	NN
cord-001835-0s7ok4uw	3422	9	within	within	IN
cord-001835-0s7ok4uw	3422	10	an	an	DT
cord-001835-0s7ok4uw	3422	11	expression	expression	NN
cord-001835-0s7ok4uw	3422	12	host	host	NN
cord-001835-0s7ok4uw	3422	13	such	such	JJ
cord-001835-0s7ok4uw	3422	14	as	as	IN
cord-001835-0s7ok4uw	3422	15	E.coli	E.coli	NNS
cord-001835-0s7ok4uw	3422	16	,	,	,
cord-001835-0s7ok4uw	3422	17	opening	open	VBG
cord-001835-0s7ok4uw	3422	18	up	up	RP
cord-001835-0s7ok4uw	3422	19	the	the	DT
cord-001835-0s7ok4uw	3422	20	possibility	possibility	NN
cord-001835-0s7ok4uw	3422	21	of	of	IN
cord-001835-0s7ok4uw	3422	22	further	further	JJ
cord-001835-0s7ok4uw	3422	23	optimization	optimization	NN
cord-001835-0s7ok4uw	3422	24	through	through	IN
cord-001835-0s7ok4uw	3422	25	directed	direct	VBN
cord-001835-0s7ok4uw	3422	26	evolution	evolution	NN
cord-001835-0s7ok4uw	3422	27	.	.	.
cord-001835-0s7ok4uw	3423	1	In	in	IN
cord-001835-0s7ok4uw	3423	2	the	the	DT
cord-001835-0s7ok4uw	3423	3	past	past	NN
cord-001835-0s7ok4uw	3423	4	targeting	targeting	NN
cord-001835-0s7ok4uw	3423	5	and	and	CC
cord-001835-0s7ok4uw	3423	6	engineering	engineering	NN
cord-001835-0s7ok4uw	3423	7	of	of	IN
cord-001835-0s7ok4uw	3423	8	chemokines	chemokine	NNS
cord-001835-0s7ok4uw	3423	9	has	have	VBZ
cord-001835-0s7ok4uw	3423	10	led	lead	VBN
cord-001835-0s7ok4uw	3423	11	to	to	IN
cord-001835-0s7ok4uw	3423	12	several	several	JJ
cord-001835-0s7ok4uw	3423	13	interesting	interesting	JJ
cord-001835-0s7ok4uw	3423	14	drug	drug	NN
cord-001835-0s7ok4uw	3423	15	candidates	candidate	NNS
cord-001835-0s7ok4uw	3423	16	.	.	.
cord-001835-0s7ok4uw	3424	1	[	[	-LRB-
cord-001835-0s7ok4uw	3424	2	1	1	CD
cord-001835-0s7ok4uw	3424	3	]	]	-RRB-
cord-001835-0s7ok4uw	3425	1	Amongst	amongst	IN
cord-001835-0s7ok4uw	3425	2	them	-PRON-	PRP
cord-001835-0s7ok4uw	3425	3	,	,	,
cord-001835-0s7ok4uw	3425	4	Met	Met	NNP
cord-001835-0s7ok4uw	3425	5	-	-	HYPH
cord-001835-0s7ok4uw	3425	6	RANTES	RANTES	NNP
cord-001835-0s7ok4uw	3425	7	,	,	,
cord-001835-0s7ok4uw	3425	8	a	a	DT
cord-001835-0s7ok4uw	3425	9	Met	Met	NNP
cord-001835-0s7ok4uw	3425	10	-	-	HYPH
cord-001835-0s7ok4uw	3425	11	CCL5	CCL5	NNP
cord-001835-0s7ok4uw	3425	12	with	with	IN
cord-001835-0s7ok4uw	3425	13	high	high	JJ
cord-001835-0s7ok4uw	3425	14	G	g	NN
cord-001835-0s7ok4uw	3425	15	protein	protein	NN
cord-001835-0s7ok4uw	3425	16	-	-	HYPH
cord-001835-0s7ok4uw	3425	17	coupled	couple	VBN
cord-001835-0s7ok4uw	3425	18	receptor	receptor	NN
cord-001835-0s7ok4uw	3425	19	(	(	-LRB-
cord-001835-0s7ok4uw	3425	20	GPCR	GPCR	NNP
cord-001835-0s7ok4uw	3425	21	)	)	-RRB-
cord-001835-0s7ok4uw	3425	22	affinity	affinity	NN
cord-001835-0s7ok4uw	3425	23	but	but	CC
cord-001835-0s7ok4uw	3425	24	no	no	DT
cord-001835-0s7ok4uw	3425	25	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	3425	26	signal	signal	NN
cord-001835-0s7ok4uw	3425	27	transduction	transduction	NN
cord-001835-0s7ok4uw	3425	28	,	,	,
cord-001835-0s7ok4uw	3425	29	as	as	RB
cord-001835-0s7ok4uw	3425	30	well	well	RB
cord-001835-0s7ok4uw	3425	31	as	as	IN
cord-001835-0s7ok4uw	3425	32	mutants	mutant	NNS
cord-001835-0s7ok4uw	3425	33	addressing	address	VBG
cord-001835-0s7ok4uw	3425	34	the	the	DT
cord-001835-0s7ok4uw	3425	35	interaction	interaction	NN
cord-001835-0s7ok4uw	3425	36	with	with	IN
cord-001835-0s7ok4uw	3425	37	the	the	DT
cord-001835-0s7ok4uw	3425	38	so	so	RB
cord-001835-0s7ok4uw	3425	39	-	-	HYPH
cord-001835-0s7ok4uw	3425	40	called	call	VBN
cord-001835-0s7ok4uw	3425	41	glycosaminoglycans	glycosaminoglycan	NNS
cord-001835-0s7ok4uw	3425	42	(	(	-LRB-
cord-001835-0s7ok4uw	3425	43	GAGs	gag	NNS
cord-001835-0s7ok4uw	3425	44	)	)	-RRB-
cord-001835-0s7ok4uw	3425	45	seem	seem	VBP
cord-001835-0s7ok4uw	3425	46	to	to	TO
cord-001835-0s7ok4uw	3425	47	be	be	VB
cord-001835-0s7ok4uw	3425	48	the	the	DT
cord-001835-0s7ok4uw	3425	49	most	most	RBS
cord-001835-0s7ok4uw	3425	50	promising	promising	JJ
cord-001835-0s7ok4uw	3425	51	candidates	candidate	NNS
cord-001835-0s7ok4uw	3425	52	.	.	.
cord-001835-0s7ok4uw	3426	1	Both	both	DT
cord-001835-0s7ok4uw	3426	2	,	,	,
cord-001835-0s7ok4uw	3426	3	GAG	gag	VB
cord-001835-0s7ok4uw	3426	4	knockout	knockout	NN
cord-001835-0s7ok4uw	3426	5	as	as	RB
cord-001835-0s7ok4uw	3426	6	well	well	RB
cord-001835-0s7ok4uw	3426	7	as	as	IN
cord-001835-0s7ok4uw	3426	8	GAG	gag	NN
cord-001835-0s7ok4uw	3426	9	affinity	affinity	NN
cord-001835-0s7ok4uw	3426	10	matured	mature	VBN
cord-001835-0s7ok4uw	3426	11	chemokine	chemokine	NN
cord-001835-0s7ok4uw	3426	12	isoforms	isoform	NNS
cord-001835-0s7ok4uw	3426	13	have	have	VBP
cord-001835-0s7ok4uw	3426	14	been	be	VBN
cord-001835-0s7ok4uw	3426	15	considered	consider	VBN
cord-001835-0s7ok4uw	3426	16	as	as	IN
cord-001835-0s7ok4uw	3426	17	anti	anti	JJ
cord-001835-0s7ok4uw	3426	18	-	-	JJ
cord-001835-0s7ok4uw	3426	19	inflammatory	inflammatory	JJ
cord-001835-0s7ok4uw	3426	20	drug	drug	NN
cord-001835-0s7ok4uw	3426	21	candidates	candidate	NNS
cord-001835-0s7ok4uw	3426	22	,	,	,
cord-001835-0s7ok4uw	3426	23	out	out	IN
cord-001835-0s7ok4uw	3426	24	of	of	IN
cord-001835-0s7ok4uw	3426	25	which	which	WDT
cord-001835-0s7ok4uw	3426	26	an	an	DT
cord-001835-0s7ok4uw	3426	27	IL-8	il-8	NN
cord-001835-0s7ok4uw	3426	28	mutant	mutant	JJ
cord-001835-0s7ok4uw	3426	29	with	with	IN
cord-001835-0s7ok4uw	3426	30	5	5	CD
cord-001835-0s7ok4uw	3426	31	modifications	modification	NNS
cord-001835-0s7ok4uw	3426	32	reached	reach	VBD
cord-001835-0s7ok4uw	3426	33	clinical	clinical	JJ
cord-001835-0s7ok4uw	3426	34	phase	phase	NN
cord-001835-0s7ok4uw	3426	35	1	1	CD
cord-001835-0s7ok4uw	3426	36	where	where	WRB
cord-001835-0s7ok4uw	3426	37	it	-PRON-	PRP
cord-001835-0s7ok4uw	3426	38	was	be	VBD
cord-001835-0s7ok4uw	3426	39	profiled	profile	VBN
cord-001835-0s7ok4uw	3426	40	for	for	IN
cord-001835-0s7ok4uw	3426	41	acute	acute	JJ
cord-001835-0s7ok4uw	3426	42	neutrophil	neutrophil	NN
cord-001835-0s7ok4uw	3426	43	-	-	HYPH
cord-001835-0s7ok4uw	3426	44	related	relate	VBN
cord-001835-0s7ok4uw	3426	45	exacerbation	exacerbation	NN
cord-001835-0s7ok4uw	3426	46	in	in	IN
cord-001835-0s7ok4uw	3426	47	COPD	COPD	NNP
cord-001835-0s7ok4uw	3426	48	.	.	.
cord-001835-0s7ok4uw	3427	1	[	[	-LRB-
cord-001835-0s7ok4uw	3427	2	2	2	CD
cord-001835-0s7ok4uw	3427	3	]	]	-RRB-
cord-001835-0s7ok4uw	3427	4	CXCL10	CXCL10	NNP
cord-001835-0s7ok4uw	3427	5	(	(	-LRB-
cord-001835-0s7ok4uw	3427	6	IP-10	IP-10	NNP
cord-001835-0s7ok4uw	3427	7	)	)	-RRB-
cord-001835-0s7ok4uw	3427	8	is	be	VBZ
cord-001835-0s7ok4uw	3427	9	a	a	DT
cord-001835-0s7ok4uw	3427	10	proinflammatory	proinflammatory	JJ
cord-001835-0s7ok4uw	3427	11	chemokine	chemokine	NN
cord-001835-0s7ok4uw	3427	12	released	release	VBN
cord-001835-0s7ok4uw	3427	13	by	by	IN
cord-001835-0s7ok4uw	3427	14	various	various	JJ
cord-001835-0s7ok4uw	3427	15	cells	cell	NNS
cord-001835-0s7ok4uw	3427	16	following	follow	VBG
cord-001835-0s7ok4uw	3427	17	stimulation	stimulation	NN
cord-001835-0s7ok4uw	3427	18	by	by	IN
cord-001835-0s7ok4uw	3427	19	interferon	interferon	NN
cord-001835-0s7ok4uw	3427	20	g	g	NN
cord-001835-0s7ok4uw	3427	21	(	(	-LRB-
cord-001835-0s7ok4uw	3427	22	IFN	IFN	NNP
cord-001835-0s7ok4uw	3427	23	-	-	HYPH
cord-001835-0s7ok4uw	3427	24	g	g	NNP
cord-001835-0s7ok4uw	3427	25	)	)	-RRB-
cord-001835-0s7ok4uw	3427	26	.	.	.
cord-001835-0s7ok4uw	3428	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3428	2	is	be	VBZ
cord-001835-0s7ok4uw	3428	3	therefore	therefore	RB
cord-001835-0s7ok4uw	3428	4	considered	consider	VBN
cord-001835-0s7ok4uw	3428	5	as	as	IN
cord-001835-0s7ok4uw	3428	6	a	a	DT
cord-001835-0s7ok4uw	3428	7	late	late	JJ
cord-001835-0s7ok4uw	3428	8	chemokine	chemokine	NN
cord-001835-0s7ok4uw	3428	9	being	be	VBG
cord-001835-0s7ok4uw	3428	10	responsible	responsible	JJ
cord-001835-0s7ok4uw	3428	11	for	for	IN
cord-001835-0s7ok4uw	3428	12	the	the	DT
cord-001835-0s7ok4uw	3428	13	attraction	attraction	NN
cord-001835-0s7ok4uw	3428	14	of	of	IN
cord-001835-0s7ok4uw	3428	15	different	different	JJ
cord-001835-0s7ok4uw	3428	16	lymphocytes	lymphocyte	NNS
cord-001835-0s7ok4uw	3428	17	.	.	.
cord-001835-0s7ok4uw	3429	1	[	[	-LRB-
cord-001835-0s7ok4uw	3429	2	3	3	LS
cord-001835-0s7ok4uw	3429	3	]	]	-RRB-
cord-001835-0s7ok4uw	3429	4	Any	any	DT
cord-001835-0s7ok4uw	3429	5	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	3429	6	indication	indication	NN
cord-001835-0s7ok4uw	3429	7	is	be	VBZ
cord-001835-0s7ok4uw	3429	8	consequently	consequently	RB
cord-001835-0s7ok4uw	3429	9	related	relate	VBN
cord-001835-0s7ok4uw	3429	10	to	to	IN
cord-001835-0s7ok4uw	3429	11	chronic	chronic	JJ
cord-001835-0s7ok4uw	3429	12	and	and	CC
cord-001835-0s7ok4uw	3429	13	multiple	multiple	JJ
cord-001835-0s7ok4uw	3429	14	applications	application	NNS
cord-001835-0s7ok4uw	3429	15	.	.	.
cord-001835-0s7ok4uw	3430	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3430	2	have	have	VBP
cord-001835-0s7ok4uw	3430	3	therefore	therefore	RB
cord-001835-0s7ok4uw	3430	4	engineered	engineer	VBN
cord-001835-0s7ok4uw	3430	5	CXCL10	CXCL10	NNP
cord-001835-0s7ok4uw	3430	6	very	very	RB
cord-001835-0s7ok4uw	3430	7	conservatively	conservatively	RB
cord-001835-0s7ok4uw	3430	8	at	at	IN
cord-001835-0s7ok4uw	3430	9	positions	position	NNS
cord-001835-0s7ok4uw	3430	10	to	to	TO
cord-001835-0s7ok4uw	3430	11	ultimately	ultimately	RB
cord-001835-0s7ok4uw	3430	12	generate	generate	VB
cord-001835-0s7ok4uw	3430	13	dominant	dominant	JJ
cord-001835-0s7ok4uw	3430	14	-	-	HYPH
cord-001835-0s7ok4uw	3430	15	negative	negative	JJ
cord-001835-0s7ok4uw	3430	16	mutants	mutant	NNS
cord-001835-0s7ok4uw	3430	17	with	with	IN
cord-001835-0s7ok4uw	3430	18	a	a	DT
cord-001835-0s7ok4uw	3430	19	mildly	mildly	RB
cord-001835-0s7ok4uw	3430	20	improved	improve	VBN
cord-001835-0s7ok4uw	3430	21	GAGbinding	gagbinding	NN
cord-001835-0s7ok4uw	3430	22	affinity	affinity	NN
cord-001835-0s7ok4uw	3430	23	and	and	CC
cord-001835-0s7ok4uw	3430	24	an	an	DT
cord-001835-0s7ok4uw	3430	25	entire	entire	JJ
cord-001835-0s7ok4uw	3430	26	knock	knock	NN
cord-001835-0s7ok4uw	3430	27	off	off	RP
cord-001835-0s7ok4uw	3430	28	GPCR	GPCR	NNP
cord-001835-0s7ok4uw	3430	29	activity	activity	NN
cord-001835-0s7ok4uw	3430	30	.	.	.
cord-001835-0s7ok4uw	3431	1	The	the	DT
cord-001835-0s7ok4uw	3431	2	first	first	JJ
cord-001835-0s7ok4uw	3431	3	steps	step	NNS
cord-001835-0s7ok4uw	3431	4	of	of	IN
cord-001835-0s7ok4uw	3431	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3431	6	engineering	engineering	NN
cord-001835-0s7ok4uw	3431	7	approach	approach	NN
cord-001835-0s7ok4uw	3431	8	were	be	VBD
cord-001835-0s7ok4uw	3431	9	in	in	IN
cord-001835-0s7ok4uw	3431	10	silico	silico	NN
cord-001835-0s7ok4uw	3431	11	modelling	modelling	NN
cord-001835-0s7ok4uw	3431	12	of	of	IN
cord-001835-0s7ok4uw	3431	13	the	the	DT
cord-001835-0s7ok4uw	3431	14	mutants	mutant	NNS
cord-001835-0s7ok4uw	3431	15	and	and	CC
cord-001835-0s7ok4uw	3431	16	the	the	DT
cord-001835-0s7ok4uw	3431	17	establishment	establishment	NN
cord-001835-0s7ok4uw	3431	18	of	of	IN
cord-001835-0s7ok4uw	3431	19	a	a	DT
cord-001835-0s7ok4uw	3431	20	suitable	suitable	JJ
cord-001835-0s7ok4uw	3431	21	upstream	upstream	NN
cord-001835-0s7ok4uw	3431	22	-	-	HYPH
cord-001835-0s7ok4uw	3431	23	and	and	CC
cord-001835-0s7ok4uw	3431	24	downstreamprocessing	downstreamprocessing	NN
cord-001835-0s7ok4uw	3431	25	protocol	protocol	NN
cord-001835-0s7ok4uw	3431	26	.	.	.
cord-001835-0s7ok4uw	3432	1	Next	next	RB
cord-001835-0s7ok4uw	3432	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3432	3	generated	generate	VBD
cord-001835-0s7ok4uw	3432	4	a	a	DT
cord-001835-0s7ok4uw	3432	5	fluorescently	fluorescently	RB
cord-001835-0s7ok4uw	3432	6	engineered	engineer	VBN
cord-001835-0s7ok4uw	3432	7	CXCL10	cxcl10	CD
cord-001835-0s7ok4uw	3432	8	variant	variant	NN
cord-001835-0s7ok4uw	3432	9	for	for	IN
cord-001835-0s7ok4uw	3432	10	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3432	11	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3432	12	-	-	HYPH
cord-001835-0s7ok4uw	3432	13	based	base	VBN
cord-001835-0s7ok4uw	3432	14	affinity	affinity	NN
cord-001835-0s7ok4uw	3432	15	studies	study	NNS
cord-001835-0s7ok4uw	3432	16	which	which	WDT
cord-001835-0s7ok4uw	3432	17	was	be	VBD
cord-001835-0s7ok4uw	3432	18	subjected	subject	VBN
cord-001835-0s7ok4uw	3432	19	to	to	IN
cord-001835-0s7ok4uw	3432	20	biocomparability	biocomparability	NN
cord-001835-0s7ok4uw	3432	21	investigations	investigation	NNS
cord-001835-0s7ok4uw	3432	22	relative	relative	JJ
cord-001835-0s7ok4uw	3432	23	to	to	IN
cord-001835-0s7ok4uw	3432	24	the	the	DT
cord-001835-0s7ok4uw	3432	25	native	native	JJ
cord-001835-0s7ok4uw	3432	26	,	,	,
cord-001835-0s7ok4uw	3432	27	non	non	JJ
cord-001835-0s7ok4uw	3432	28	-	-	JJ
cord-001835-0s7ok4uw	3432	29	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	3432	30	protein	protein	NN
cord-001835-0s7ok4uw	3432	31	.	.	.
cord-001835-0s7ok4uw	3433	1	Compared	compare	VBN
cord-001835-0s7ok4uw	3433	2	to	to	IN
cord-001835-0s7ok4uw	3433	3	the	the	DT
cord-001835-0s7ok4uw	3433	4	wild	wild	JJ
cord-001835-0s7ok4uw	3433	5	type	type	NN
cord-001835-0s7ok4uw	3433	6	,	,	,
cord-001835-0s7ok4uw	3433	7	the	the	DT
cord-001835-0s7ok4uw	3433	8	fluorescently	fluorescently	RB
cord-001835-0s7ok4uw	3433	9	engineered	engineer	VBN
cord-001835-0s7ok4uw	3433	10	mutant	mutant	NN
cord-001835-0s7ok4uw	3433	11	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	3433	12	similar	similar	JJ
cord-001835-0s7ok4uw	3433	13	biological	biological	JJ
cord-001835-0s7ok4uw	3433	14	,	,	,
cord-001835-0s7ok4uw	3433	15	chemotactic	chemotactic	JJ
cord-001835-0s7ok4uw	3433	16	and	and	CC
cord-001835-0s7ok4uw	3433	17	GAG	gag	NN
cord-001835-0s7ok4uw	3433	18	-	-	HYPH
cord-001835-0s7ok4uw	3433	19	binding	bind	VBG
cord-001835-0s7ok4uw	3433	20	properties	property	NNS
cord-001835-0s7ok4uw	3433	21	.	.	.
cord-001835-0s7ok4uw	3434	1	Next	next	RB
cord-001835-0s7ok4uw	3434	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3434	3	started	start	VBD
cord-001835-0s7ok4uw	3434	4	to	to	TO
cord-001835-0s7ok4uw	3434	5	produce	produce	VB
cord-001835-0s7ok4uw	3434	6	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	3434	7	amounts	amount	NNS
cord-001835-0s7ok4uw	3434	8	of	of	IN
cord-001835-0s7ok4uw	3434	9	the	the	DT
cord-001835-0s7ok4uw	3434	10	members	member	NNS
cord-001835-0s7ok4uw	3434	11	of	of	IN
cord-001835-0s7ok4uw	3434	12	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3434	13	nascent	nascent	JJ
cord-001835-0s7ok4uw	3434	14	mutant	mutant	JJ
cord-001835-0s7ok4uw	3434	15	library	library	NN
cord-001835-0s7ok4uw	3434	16	which	which	WDT
cord-001835-0s7ok4uw	3434	17	were	be	VBD
cord-001835-0s7ok4uw	3434	18	tested	test	VBN
cord-001835-0s7ok4uw	3434	19	with	with	IN
cord-001835-0s7ok4uw	3434	20	respect	respect	NN
cord-001835-0s7ok4uw	3434	21	to	to	IN
cord-001835-0s7ok4uw	3434	22	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3434	23	biophysically	biophysically	NN
cord-001835-0s7ok4uw	3434	24	behavior	behavior	NN
cord-001835-0s7ok4uw	3434	25	as	as	RB
cord-001835-0s7ok4uw	3434	26	well	well	RB
cord-001835-0s7ok4uw	3434	27	as	as	IN
cord-001835-0s7ok4uw	3434	28	to	to	IN
cord-001835-0s7ok4uw	3434	29	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3434	30	knocked	knock	VBN
cord-001835-0s7ok4uw	3434	31	out	out	RP
cord-001835-0s7ok4uw	3434	32	chemotactic	chemotactic	JJ
cord-001835-0s7ok4uw	3434	33	potency	potency	NN
cord-001835-0s7ok4uw	3434	34	on	on	IN
cord-001835-0s7ok4uw	3434	35	cells	cell	NNS
cord-001835-0s7ok4uw	3434	36	.	.	.
cord-001835-0s7ok4uw	3435	1	These	these	DT
cord-001835-0s7ok4uw	3435	2	experiments	experiment	NNS
cord-001835-0s7ok4uw	3435	3	included	include	VBD
cord-001835-0s7ok4uw	3435	4	gel	gel	NN
cord-001835-0s7ok4uw	3435	5	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	3435	6	and	and	CC
cord-001835-0s7ok4uw	3435	7	Western	western	JJ
cord-001835-0s7ok4uw	3435	8	Blot	Blot	NNP
cord-001835-0s7ok4uw	3435	9	analysis	analysis	NN
cord-001835-0s7ok4uw	3435	10	to	to	TO
cord-001835-0s7ok4uw	3435	11	determine	determine	VB
cord-001835-0s7ok4uw	3435	12	identity	identity	NN
cord-001835-0s7ok4uw	3435	13	and	and	CC
cord-001835-0s7ok4uw	3435	14	purity	purity	NN
cord-001835-0s7ok4uw	3435	15	;	;	:
cord-001835-0s7ok4uw	3435	16	Circular	Circular	NNP
cord-001835-0s7ok4uw	3435	17	Dichroism	Dichroism	NNP
cord-001835-0s7ok4uw	3435	18	(	(	-LRB-
cord-001835-0s7ok4uw	3435	19	CD	CD	NNP
cord-001835-0s7ok4uw	3435	20	)	)	-RRB-
cord-001835-0s7ok4uw	3435	21	and	and	CC
cord-001835-0s7ok4uw	3435	22	chaotrope	chaotrope	NN
cord-001835-0s7ok4uw	3435	23	-	-	HYPH
cord-001835-0s7ok4uw	3435	24	induced	induce	VBN
cord-001835-0s7ok4uw	3435	25	unfolding	unfold	VBG
cord-001835-0s7ok4uw	3435	26	to	to	TO
cord-001835-0s7ok4uw	3435	27	approximate	approximate	JJ
cord-001835-0s7ok4uw	3435	28	structure	structure	NN
cord-001835-0s7ok4uw	3435	29	;	;	:
cord-001835-0s7ok4uw	3435	30	Isothermal	Isothermal	NNP
cord-001835-0s7ok4uw	3435	31	Fluorescence	Fluorescence	NNP
cord-001835-0s7ok4uw	3435	32	Titration	Titration	NNP
cord-001835-0s7ok4uw	3435	33	(	(	-LRB-
cord-001835-0s7ok4uw	3435	34	IFT	IFT	NNP
cord-001835-0s7ok4uw	3435	35	)	)	-RRB-
cord-001835-0s7ok4uw	3435	36	;	;	:
cord-001835-0s7ok4uw	3435	37	Surface	Surface	NNP
cord-001835-0s7ok4uw	3435	38	Plasmon	Plasmon	NNP
cord-001835-0s7ok4uw	3435	39	Resonance	Resonance	NNP
cord-001835-0s7ok4uw	3435	40	(	(	-LRB-
cord-001835-0s7ok4uw	3435	41	SPR	SPR	NNP
cord-001835-0s7ok4uw	3435	42	)	)	-RRB-
cord-001835-0s7ok4uw	3435	43	and	and	CC
cord-001835-0s7ok4uw	3435	44	Isothermal	Isothermal	NNP
cord-001835-0s7ok4uw	3435	45	Titration	Titration	NNP
cord-001835-0s7ok4uw	3435	46	Calorimetry	Calorimetry	NNP
cord-001835-0s7ok4uw	3435	47	(	(	-LRB-
cord-001835-0s7ok4uw	3435	48	ITC	ITC	NNP
cord-001835-0s7ok4uw	3435	49	)	)	-RRB-
cord-001835-0s7ok4uw	3435	50	to	to	TO
cord-001835-0s7ok4uw	3435	51	quantify	quantify	VB
cord-001835-0s7ok4uw	3435	52	GAGbinding	gagbinding	NN
cord-001835-0s7ok4uw	3435	53	affinity	affinity	NN
cord-001835-0s7ok4uw	3435	54	and	and	CC
cord-001835-0s7ok4uw	3435	55	Boyden	Boyden	NNP
cord-001835-0s7ok4uw	3435	56	Chamber	Chamber	NNP
cord-001835-0s7ok4uw	3435	57	experiments	experiment	NNS
cord-001835-0s7ok4uw	3435	58	to	to	TO
cord-001835-0s7ok4uw	3435	59	determine	determine	VB
cord-001835-0s7ok4uw	3435	60	the	the	DT
cord-001835-0s7ok4uw	3435	61	chemotactic	chemotactic	JJ
cord-001835-0s7ok4uw	3435	62	activity	activity	NN
cord-001835-0s7ok4uw	3435	63	.	.	.
cord-001835-0s7ok4uw	3436	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3436	2	results	result	NNS
cord-001835-0s7ok4uw	3436	3	show	show	VBP
cord-001835-0s7ok4uw	3436	4	that	that	IN
cord-001835-0s7ok4uw	3436	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3436	6	are	be	VBP
cord-001835-0s7ok4uw	3436	7	able	able	JJ
cord-001835-0s7ok4uw	3436	8	to	to	TO
cord-001835-0s7ok4uw	3436	9	tune	tune	VB
cord-001835-0s7ok4uw	3436	10	the	the	DT
cord-001835-0s7ok4uw	3436	11	GAG	gag	NN
cord-001835-0s7ok4uw	3436	12	binding	binding	NN
cord-001835-0s7ok4uw	3436	13	strength	strength	NN
cord-001835-0s7ok4uw	3436	14	along	along	IN
cord-001835-0s7ok4uw	3436	15	with	with	IN
cord-001835-0s7ok4uw	3436	16	the	the	DT
cord-001835-0s7ok4uw	3436	17	GPCR	GPCR	NNP
cord-001835-0s7ok4uw	3436	18	activity	activity	NN
cord-001835-0s7ok4uw	3436	19	of	of	IN
cord-001835-0s7ok4uw	3436	20	human	human	JJ
cord-001835-0s7ok4uw	3436	21	CXCL10	CXCL10	NNP
cord-001835-0s7ok4uw	3436	22	which	which	WDT
cord-001835-0s7ok4uw	3436	23	could	could	MD
cord-001835-0s7ok4uw	3436	24	lead	lead	VB
cord-001835-0s7ok4uw	3436	25	to	to	IN
cord-001835-0s7ok4uw	3436	26	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	3436	27	applications	application	NNS
cord-001835-0s7ok4uw	3436	28	in	in	IN
cord-001835-0s7ok4uw	3436	29	the	the	DT
cord-001835-0s7ok4uw	3436	30	future	future	NN
cord-001835-0s7ok4uw	3436	31	.	.	.
cord-001835-0s7ok4uw	3437	1	Nanodiscs	Nanodiscs	NNP
cord-001835-0s7ok4uw	3437	2	are	be	VBP
cord-001835-0s7ok4uw	3437	3	composed	compose	VBN
cord-001835-0s7ok4uw	3437	4	of	of	IN
cord-001835-0s7ok4uw	3437	5	a	a	DT
cord-001835-0s7ok4uw	3437	6	nanometer	nanometer	NN
cord-001835-0s7ok4uw	3437	7	-	-	HYPH
cord-001835-0s7ok4uw	3437	8	sized	sized	JJ
cord-001835-0s7ok4uw	3437	9	phospholipid	phospholipid	NN
cord-001835-0s7ok4uw	3437	10	bilayer	bilayer	NN
cord-001835-0s7ok4uw	3437	11	encircled	encircle	VBN
cord-001835-0s7ok4uw	3437	12	by	by	IN
cord-001835-0s7ok4uw	3437	13	two	two	CD
cord-001835-0s7ok4uw	3437	14	a	a	DT
cord-001835-0s7ok4uw	3437	15	helical	helical	JJ
cord-001835-0s7ok4uw	3437	16	,	,	,
cord-001835-0s7ok4uw	3437	17	amphipathic	amphipathic	JJ
cord-001835-0s7ok4uw	3437	18	membrane	membrane	NN
cord-001835-0s7ok4uw	3437	19	scaffold	scaffold	NN
cord-001835-0s7ok4uw	3437	20	proteins	protein	NNS
cord-001835-0s7ok4uw	3437	21	(	(	-LRB-
cord-001835-0s7ok4uw	3437	22	MSPs	MSPs	NNP
cord-001835-0s7ok4uw	3437	23	)	)	-RRB-
cord-001835-0s7ok4uw	3437	24	.	.	.
cord-001835-0s7ok4uw	3438	1	These	these	DT
cord-001835-0s7ok4uw	3438	2	particles	particle	NNS
cord-001835-0s7ok4uw	3438	3	provide	provide	VBP
cord-001835-0s7ok4uw	3438	4	a	a	DT
cord-001835-0s7ok4uw	3438	5	unique	unique	JJ
cord-001835-0s7ok4uw	3438	6	detergent	detergent	NN
cord-001835-0s7ok4uw	3438	7	free	free	JJ
cord-001835-0s7ok4uw	3438	8	lipid	lipid	NN
cord-001835-0s7ok4uw	3438	9	bilayer	bilayer	NN
cord-001835-0s7ok4uw	3438	10	model	model	NN
cord-001835-0s7ok4uw	3438	11	enabling	enable	VBG
cord-001835-0s7ok4uw	3438	12	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	3438	13	and	and	CC
cord-001835-0s7ok4uw	3438	14	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	3438	15	characterization	characterization	NN
cord-001835-0s7ok4uw	3438	16	of	of	IN
cord-001835-0s7ok4uw	3438	17	membrane	membrane	NN
cord-001835-0s7ok4uw	3438	18	proteins	protein	NNS
cord-001835-0s7ok4uw	3438	19	in	in	IN
cord-001835-0s7ok4uw	3438	20	a	a	DT
cord-001835-0s7ok4uw	3438	21	physiologically	physiologically	RB
cord-001835-0s7ok4uw	3438	22	relevant	relevant	JJ
cord-001835-0s7ok4uw	3438	23	medium	medium	NN
cord-001835-0s7ok4uw	3438	24	.	.	.
cord-001835-0s7ok4uw	3439	1	Previously	previously	RB
cord-001835-0s7ok4uw	3439	2	,	,	,
cord-001835-0s7ok4uw	3439	3	the	the	DT
cord-001835-0s7ok4uw	3439	4	largest	large	JJS
cord-001835-0s7ok4uw	3439	5	diameter	diameter	NN
cord-001835-0s7ok4uw	3439	6	reported	report	VBN
cord-001835-0s7ok4uw	3439	7	of	of	IN
cord-001835-0s7ok4uw	3439	8	a	a	DT
cord-001835-0s7ok4uw	3439	9	nanodisc	nanodisc	NN
cord-001835-0s7ok4uw	3439	10	assembled	assemble	VBN
cord-001835-0s7ok4uw	3439	11	using	use	VBG
cord-001835-0s7ok4uw	3439	12	MSPs	msp	NNS
cord-001835-0s7ok4uw	3439	13	was	be	VBD
cord-001835-0s7ok4uw	3439	14	about	about	RB
cord-001835-0s7ok4uw	3439	15	16	16	CD
cord-001835-0s7ok4uw	3439	16	-	-	SYM
cord-001835-0s7ok4uw	3439	17	17	17	CD
cord-001835-0s7ok4uw	3439	18	nm	nm	NN
cord-001835-0s7ok4uw	3439	19	.	.	.
cord-001835-0s7ok4uw	3440	1	Here	here	RB
cord-001835-0s7ok4uw	3440	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3440	3	present	present	VBP
cord-001835-0s7ok4uw	3440	4	a	a	DT
cord-001835-0s7ok4uw	3440	5	method	method	NN
cord-001835-0s7ok4uw	3440	6	to	to	TO
cord-001835-0s7ok4uw	3440	7	create	create	VB
cord-001835-0s7ok4uw	3440	8	large	large	JJ
cord-001835-0s7ok4uw	3440	9	nanodiscs	nanodiscs	NN
cord-001835-0s7ok4uw	3440	10	(	(	-LRB-
cord-001835-0s7ok4uw	3440	11	up	up	IN
cord-001835-0s7ok4uw	3440	12	to	to	TO
cord-001835-0s7ok4uw	3440	13	80	80	CD
cord-001835-0s7ok4uw	3440	14	nm	nm	NN
cord-001835-0s7ok4uw	3440	15	in	in	IN
cord-001835-0s7ok4uw	3440	16	diameter	diameter	NN
cord-001835-0s7ok4uw	3440	17	)	)	-RRB-
cord-001835-0s7ok4uw	3440	18	assembled	assemble	VBN
cord-001835-0s7ok4uw	3440	19	with	with	IN
cord-001835-0s7ok4uw	3440	20	covalently	covalently	RB
cord-001835-0s7ok4uw	3440	21	circularized	circularize	VBN
cord-001835-0s7ok4uw	3440	22	MSPs	msp	NNS
cord-001835-0s7ok4uw	3440	23	(	(	-LRB-
cord-001835-0s7ok4uw	3440	24	cMSP	cmsp	JJ
cord-001835-0s7ok4uw	3440	25	)	)	-RRB-
cord-001835-0s7ok4uw	3440	26	.	.	.
cord-001835-0s7ok4uw	3441	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3441	2	can	can	MD
cord-001835-0s7ok4uw	3441	3	observe	observe	VB
cord-001835-0s7ok4uw	3441	4	the	the	DT
cord-001835-0s7ok4uw	3441	5	homogeneity	homogeneity	NN
cord-001835-0s7ok4uw	3441	6	in	in	IN
cord-001835-0s7ok4uw	3441	7	nanodiscs	nanodiscs	NNP
cord-001835-0s7ok4uw	3441	8	diameter	diameter	NN
cord-001835-0s7ok4uw	3441	9	as	as	IN
cord-001835-0s7ok4uw	3441	10	a	a	DT
cord-001835-0s7ok4uw	3441	11	narrow	narrow	JJ
cord-001835-0s7ok4uw	3441	12	distribution	distribution	NN
cord-001835-0s7ok4uw	3441	13	using	use	VBG
cord-001835-0s7ok4uw	3441	14	negative	negative	JJ
cord-001835-0s7ok4uw	3441	15	-	-	HYPH
cord-001835-0s7ok4uw	3441	16	stain	stain	NN
cord-001835-0s7ok4uw	3441	17	EM	em	NN
cord-001835-0s7ok4uw	3441	18	.	.	.
cord-001835-0s7ok4uw	3442	1	Using	use	VBG
cord-001835-0s7ok4uw	3442	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3442	3	method	method	NN
cord-001835-0s7ok4uw	3442	4	,	,	,
cord-001835-0s7ok4uw	3442	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3442	6	have	have	VBP
cord-001835-0s7ok4uw	3442	7	created	create	VBN
cord-001835-0s7ok4uw	3442	8	50	50	CD
cord-001835-0s7ok4uw	3442	9	nm	nm	NNP
cord-001835-0s7ok4uw	3442	10	nanodiscs	nanodiscs	NNP
cord-001835-0s7ok4uw	3442	11	and	and	CC
cord-001835-0s7ok4uw	3442	12	used	use	VBD
cord-001835-0s7ok4uw	3442	13	them	-PRON-	PRP
cord-001835-0s7ok4uw	3442	14	to	to	TO
cord-001835-0s7ok4uw	3442	15	study	study	VB
cord-001835-0s7ok4uw	3442	16	poliovirus	poliovirus	NN
cord-001835-0s7ok4uw	3442	17	(	(	-LRB-
cord-001835-0s7ok4uw	3442	18	35	35	CD
cord-001835-0s7ok4uw	3442	19	nm	nm	NN
cord-001835-0s7ok4uw	3442	20	diameter	diameter	NN
cord-001835-0s7ok4uw	3442	21	)	)	-RRB-
cord-001835-0s7ok4uw	3442	22	entry	entry	NN
cord-001835-0s7ok4uw	3442	23	and	and	CC
cord-001835-0s7ok4uw	3442	24	RNA	RNA	NNP
cord-001835-0s7ok4uw	3442	25	translocation	translocation	NN
cord-001835-0s7ok4uw	3442	26	.	.	.
cord-001835-0s7ok4uw	3443	1	A	a	DT
cord-001835-0s7ok4uw	3443	2	50	50	CD
cord-001835-0s7ok4uw	3443	3	nm	nm	NNP
cord-001835-0s7ok4uw	3443	4	nanodisc	nanodisc	NNP
cord-001835-0s7ok4uw	3443	5	is	be	VBZ
cord-001835-0s7ok4uw	3443	6	sufficiently	sufficiently	RB
cord-001835-0s7ok4uw	3443	7	large	large	JJ
cord-001835-0s7ok4uw	3443	8	to	to	TO
cord-001835-0s7ok4uw	3443	9	accommodate	accommodate	VB
cord-001835-0s7ok4uw	3443	10	multiple	multiple	JJ
cord-001835-0s7ok4uw	3443	11	copies	copy	NNS
cord-001835-0s7ok4uw	3443	12	of	of	IN
cord-001835-0s7ok4uw	3443	13	the	the	DT
cord-001835-0s7ok4uw	3443	14	CD155	cd155	NN
cord-001835-0s7ok4uw	3443	15	receptor	receptor	NN
cord-001835-0s7ok4uw	3443	16	(	(	-LRB-
cord-001835-0s7ok4uw	3443	17	also	also	RB
cord-001835-0s7ok4uw	3443	18	known	know	VBN
cord-001835-0s7ok4uw	3443	19	as	as	IN
cord-001835-0s7ok4uw	3443	20	the	the	DT
cord-001835-0s7ok4uw	3443	21	poliovirus	poliovirus	NN
cord-001835-0s7ok4uw	3443	22	receptor	receptor	NN
cord-001835-0s7ok4uw	3443	23	)	)	-RRB-
cord-001835-0s7ok4uw	3443	24	,	,	,
cord-001835-0s7ok4uw	3443	25	and	and	CC
cord-001835-0s7ok4uw	3443	26	has	have	VBZ
cord-001835-0s7ok4uw	3443	27	enough	enough	JJ
cord-001835-0s7ok4uw	3443	28	surface	surface	NN
cord-001835-0s7ok4uw	3443	29	area	area	NN
cord-001835-0s7ok4uw	3443	30	to	to	TO
cord-001835-0s7ok4uw	3443	31	act	act	VB
cord-001835-0s7ok4uw	3443	32	as	as	IN
cord-001835-0s7ok4uw	3443	33	a	a	DT
cord-001835-0s7ok4uw	3443	34	surrogate	surrogate	JJ
cord-001835-0s7ok4uw	3443	35	membrane	membrane	NN
cord-001835-0s7ok4uw	3443	36	for	for	IN
cord-001835-0s7ok4uw	3443	37	the	the	DT
cord-001835-0s7ok4uw	3443	38	RNA	RNA	NNP
cord-001835-0s7ok4uw	3443	39	translocation	translocation	NN
cord-001835-0s7ok4uw	3443	40	complex	complex	NN
cord-001835-0s7ok4uw	3443	41	during	during	IN
cord-001835-0s7ok4uw	3443	42	viral	viral	JJ
cord-001835-0s7ok4uw	3443	43	uncoating	uncoating	NN
cord-001835-0s7ok4uw	3443	44	.	.	.
cord-001835-0s7ok4uw	3444	1	The	the	DT
cord-001835-0s7ok4uw	3444	2	50	50	CD
cord-001835-0s7ok4uw	3444	3	nm	nm	NN
cord-001835-0s7ok4uw	3444	4	nanodiscs	nanodiscs	NN
cord-001835-0s7ok4uw	3444	5	functionalized	functionalize	VBN
cord-001835-0s7ok4uw	3444	6	with	with	IN
cord-001835-0s7ok4uw	3444	7	the	the	DT
cord-001835-0s7ok4uw	3444	8	His	His	NNP
cord-001835-0s7ok4uw	3444	9	-	-	HYPH
cord-001835-0s7ok4uw	3444	10	tagged	tag	VBN
cord-001835-0s7ok4uw	3444	11	ectodomain	ectodomain	NN
cord-001835-0s7ok4uw	3444	12	of	of	IN
cord-001835-0s7ok4uw	3444	13	poliovirus	poliovirus	NN
cord-001835-0s7ok4uw	3444	14	receptor	receptor	NN
cord-001835-0s7ok4uw	3444	15	,	,	,
cord-001835-0s7ok4uw	3444	16	CD155	CD155	NNP
cord-001835-0s7ok4uw	3444	17	,	,	,
cord-001835-0s7ok4uw	3444	18	were	be	VBD
cord-001835-0s7ok4uw	3444	19	generated	generate	VBN
cord-001835-0s7ok4uw	3444	20	by	by	IN
cord-001835-0s7ok4uw	3444	21	adding	add	VBG
cord-001835-0s7ok4uw	3444	22	lipids	lipid	NNS
cord-001835-0s7ok4uw	3444	23	derivatized	derivatize	VBN
cord-001835-0s7ok4uw	3444	24	with	with	IN
cord-001835-0s7ok4uw	3444	25	a	a	DT
cord-001835-0s7ok4uw	3444	26	NTA	NTA	NNP
cord-001835-0s7ok4uw	3444	27	nickel-	nickel-	JJ
cord-001835-0s7ok4uw	3444	28	chelating	chelating	JJ
cord-001835-0s7ok4uw	3444	29	head	head	NN
cord-001835-0s7ok4uw	3444	30	group	group	NN
cord-001835-0s7ok4uw	3444	31	to	to	IN
cord-001835-0s7ok4uw	3444	32	the	the	DT
cord-001835-0s7ok4uw	3444	33	lipid	lipid	NN
cord-001835-0s7ok4uw	3444	34	mixture	mixture	NN
cord-001835-0s7ok4uw	3444	35	during	during	IN
cord-001835-0s7ok4uw	3444	36	nanodisc	nanodisc	NNP
cord-001835-0s7ok4uw	3444	37	assembly	assembly	NNP
cord-001835-0s7ok4uw	3444	38	.	.	.
cord-001835-0s7ok4uw	3445	1	CD155	CD155	NNP
cord-001835-0s7ok4uw	3446	1	receptor	receptor	NN
cord-001835-0s7ok4uw	3446	2	was	be	VBD
cord-001835-0s7ok4uw	3446	3	added	add	VBN
cord-001835-0s7ok4uw	3446	4	to	to	IN
cord-001835-0s7ok4uw	3446	5	the	the	DT
cord-001835-0s7ok4uw	3446	6	already	already	RB
cord-001835-0s7ok4uw	3446	7	assembled	assemble	VBN
cord-001835-0s7ok4uw	3446	8	nanodiscs	nanodiscs	NNP
cord-001835-0s7ok4uw	3446	9	and	and	CC
cord-001835-0s7ok4uw	3446	10	incubated	incubate	VBN
cord-001835-0s7ok4uw	3446	11	for	for	IN
cord-001835-0s7ok4uw	3446	12	30	30	CD
cord-001835-0s7ok4uw	3446	13	minutes	minute	NNS
cord-001835-0s7ok4uw	3446	14	at	at	IN
cord-001835-0s7ok4uw	3446	15	room	room	NN
cord-001835-0s7ok4uw	3446	16	temperature	temperature	NN
cord-001835-0s7ok4uw	3446	17	.	.	.
cord-001835-0s7ok4uw	3447	1	The	the	DT
cord-001835-0s7ok4uw	3447	2	receptordecorated	receptordecorated	JJ
cord-001835-0s7ok4uw	3447	3	nanodisc	nanodisc	NN
cord-001835-0s7ok4uw	3447	4	complex	complex	NN
cord-001835-0s7ok4uw	3447	5	was	be	VBD
cord-001835-0s7ok4uw	3447	6	purified	purify	VBN
cord-001835-0s7ok4uw	3447	7	by	by	IN
cord-001835-0s7ok4uw	3447	8	size	size	NN
cord-001835-0s7ok4uw	3447	9	exclusion	exclusion	NN
cord-001835-0s7ok4uw	3447	10	chromatography	chromatography	NN
cord-001835-0s7ok4uw	3447	11	.	.	.
cord-001835-0s7ok4uw	3448	1	The	the	DT
cord-001835-0s7ok4uw	3448	2	purified	purify	VBN
cord-001835-0s7ok4uw	3448	3	complex	complex	NN
cord-001835-0s7ok4uw	3448	4	was	be	VBD
cord-001835-0s7ok4uw	3448	5	then	then	RB
cord-001835-0s7ok4uw	3448	6	incubated	incubate	VBN
cord-001835-0s7ok4uw	3448	7	with	with	IN
cord-001835-0s7ok4uw	3448	8	poliovirus	poliovirus	NN
cord-001835-0s7ok4uw	3448	9	for	for	IN
cord-001835-0s7ok4uw	3448	10	5	5	CD
cord-001835-0s7ok4uw	3448	11	minute	minute	NN
cord-001835-0s7ok4uw	3448	12	at	at	IN
cord-001835-0s7ok4uw	3448	13	4	4	CD
cord-001835-0s7ok4uw	3448	14	C	C	NNP
cord-001835-0s7ok4uw	3448	15	,	,	,
cord-001835-0s7ok4uw	3448	16	and	and	CC
cord-001835-0s7ok4uw	3448	17	then	then	RB
cord-001835-0s7ok4uw	3448	18	heated	heat	VBD
cord-001835-0s7ok4uw	3448	19	to	to	IN
cord-001835-0s7ok4uw	3448	20	37	37	CD
cord-001835-0s7ok4uw	3448	21	C	c	NN
cord-001835-0s7ok4uw	3448	22	for	for	IN
cord-001835-0s7ok4uw	3448	23	15	15	CD
cord-001835-0s7ok4uw	3448	24	minutes	minute	NNS
cord-001835-0s7ok4uw	3448	25	to	to	TO
cord-001835-0s7ok4uw	3448	26	initiate	initiate	VB
cord-001835-0s7ok4uw	3448	27	receptor	receptor	NN
cord-001835-0s7ok4uw	3448	28	-	-	HYPH
cord-001835-0s7ok4uw	3448	29	mediated	mediate	VBN
cord-001835-0s7ok4uw	3448	30	viral	viral	JJ
cord-001835-0s7ok4uw	3448	31	uncoating	uncoating	NN
cord-001835-0s7ok4uw	3448	32	.	.	.
cord-001835-0s7ok4uw	3449	1	Virus	virus	NN
cord-001835-0s7ok4uw	3449	2	binding	bind	VBG
cord-001835-0s7ok4uw	3449	3	to	to	IN
cord-001835-0s7ok4uw	3449	4	nanodisc	nanodisc	NNP
cord-001835-0s7ok4uw	3449	5	-	-	HYPH
cord-001835-0s7ok4uw	3449	6	CD155	cd155	NN
cord-001835-0s7ok4uw	3449	7	complex	complex	NN
cord-001835-0s7ok4uw	3449	8	and	and	CC
cord-001835-0s7ok4uw	3449	9	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	3449	10	insertion	insertion	NN
cord-001835-0s7ok4uw	3449	11	of	of	IN
cord-001835-0s7ok4uw	3449	12	viral	viral	JJ
cord-001835-0s7ok4uw	3449	13	components	component	NNS
cord-001835-0s7ok4uw	3449	14	into	into	IN
cord-001835-0s7ok4uw	3449	15	and	and	CC
cord-001835-0s7ok4uw	3449	16	across	across	IN
cord-001835-0s7ok4uw	3449	17	the	the	DT
cord-001835-0s7ok4uw	3449	18	membrane	membrane	NN
cord-001835-0s7ok4uw	3449	19	were	be	VBD
cord-001835-0s7ok4uw	3449	20	confirmed	confirm	VBN
cord-001835-0s7ok4uw	3449	21	by	by	IN
cord-001835-0s7ok4uw	3449	22	negative	negative	JJ
cord-001835-0s7ok4uw	3449	23	-	-	HYPH
cord-001835-0s7ok4uw	3449	24	stain	stain	NN
cord-001835-0s7ok4uw	3449	25	electron	electron	NN
cord-001835-0s7ok4uw	3449	26	microscopy	microscopy	NN
cord-001835-0s7ok4uw	3449	27	(	(	-LRB-
cord-001835-0s7ok4uw	3449	28	Figure	figure	NN
cord-001835-0s7ok4uw	3449	29	1c	1c	CD
cord-001835-0s7ok4uw	3449	30	)	)	-RRB-
cord-001835-0s7ok4uw	3449	31	.	.	.
cord-001835-0s7ok4uw	3450	1	To	to	TO
cord-001835-0s7ok4uw	3450	2	obtain	obtain	VB
cord-001835-0s7ok4uw	3450	3	a	a	DT
cord-001835-0s7ok4uw	3450	4	high	high	JJ
cord-001835-0s7ok4uw	3450	5	-	-	HYPH
cord-001835-0s7ok4uw	3450	6	resolution	resolution	NN
cord-001835-0s7ok4uw	3450	7	structure	structure	NN
cord-001835-0s7ok4uw	3450	8	for	for	IN
cord-001835-0s7ok4uw	3450	9	the	the	DT
cord-001835-0s7ok4uw	3450	10	RNA	RNA	NNP
cord-001835-0s7ok4uw	3450	11	translocation	translocation	NN
cord-001835-0s7ok4uw	3450	12	complex	complex	NN
cord-001835-0s7ok4uw	3450	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	3450	14	conducted	conduct	VBD
cord-001835-0s7ok4uw	3450	15	single	single	JJ
cord-001835-0s7ok4uw	3450	16	-	-	HYPH
cord-001835-0s7ok4uw	3450	17	particle	particle	NN
cord-001835-0s7ok4uw	3450	18	cryo	cryo	NN
cord-001835-0s7ok4uw	3450	19	-	-	HYPH
cord-001835-0s7ok4uw	3450	20	EM	EM	NNP
cord-001835-0s7ok4uw	3450	21	studies	study	NNS
cord-001835-0s7ok4uw	3450	22	using	use	VBG
cord-001835-0s7ok4uw	3450	23	a	a	DT
cord-001835-0s7ok4uw	3450	24	Polara	Polara	NNP
cord-001835-0s7ok4uw	3450	25	F30	F30	NNP
cord-001835-0s7ok4uw	3450	26	microscope	microscope	NN
cord-001835-0s7ok4uw	3450	27	.	.	.
cord-001835-0s7ok4uw	3451	1	Unlike	unlike	IN
cord-001835-0s7ok4uw	3451	2	liposomes	liposome	NNS
cord-001835-0s7ok4uw	3451	3	,	,	,
cord-001835-0s7ok4uw	3451	4	generating	generate	VBG
cord-001835-0s7ok4uw	3451	5	a	a	DT
cord-001835-0s7ok4uw	3451	6	reconstruction	reconstruction	NN
cord-001835-0s7ok4uw	3451	7	of	of	IN
cord-001835-0s7ok4uw	3451	8	samples	sample	NNS
cord-001835-0s7ok4uw	3451	9	containing	contain	VBG
cord-001835-0s7ok4uw	3451	10	nanodiscs	nanodiscs	NNP
cord-001835-0s7ok4uw	3451	11	is	be	VBZ
cord-001835-0s7ok4uw	3451	12	less	less	RBR
cord-001835-0s7ok4uw	3451	13	complicated	complicated	JJ
cord-001835-0s7ok4uw	3451	14	since	since	IN
cord-001835-0s7ok4uw	3451	15	the	the	DT
cord-001835-0s7ok4uw	3451	16	nanodiscs	nanodiscs	NN
cord-001835-0s7ok4uw	3451	17	are	be	VBP
cord-001835-0s7ok4uw	3451	18	more	more	RBR
cord-001835-0s7ok4uw	3451	19	homogenous	homogenous	JJ
cord-001835-0s7ok4uw	3451	20	in	in	IN
cord-001835-0s7ok4uw	3451	21	size	size	NN
cord-001835-0s7ok4uw	3451	22	,	,	,
cord-001835-0s7ok4uw	3451	23	and	and	CC
cord-001835-0s7ok4uw	3451	24	allow	allow	VB
cord-001835-0s7ok4uw	3451	25	for	for	IN
cord-001835-0s7ok4uw	3451	26	thinner	thin	JJR
cord-001835-0s7ok4uw	3451	27	ice	ice	NN
cord-001835-0s7ok4uw	3451	28	.	.	.
cord-001835-0s7ok4uw	3452	1	Also	also	RB
cord-001835-0s7ok4uw	3452	2	,	,	,
cord-001835-0s7ok4uw	3452	3	the	the	DT
cord-001835-0s7ok4uw	3452	4	viral	viral	JJ
cord-001835-0s7ok4uw	3452	5	RNA	RNA	NNP
cord-001835-0s7ok4uw	3452	6	can	can	MD
cord-001835-0s7ok4uw	3452	7	be	be	VB
cord-001835-0s7ok4uw	3452	8	visualized	visualize	VBN
cord-001835-0s7ok4uw	3452	9	more	more	RBR
cord-001835-0s7ok4uw	3452	10	easily	easily	RB
cord-001835-0s7ok4uw	3452	11	.	.	.
cord-001835-0s7ok4uw	3453	1	The	the	DT
cord-001835-0s7ok4uw	3453	2	method	method	NN
cord-001835-0s7ok4uw	3453	3	for	for	IN
cord-001835-0s7ok4uw	3453	4	making	make	VBG
cord-001835-0s7ok4uw	3453	5	large	large	JJ
cord-001835-0s7ok4uw	3453	6	nanodiscs	nanodiscs	NN
cord-001835-0s7ok4uw	3453	7	as	as	RB
cord-001835-0s7ok4uw	3453	8	well	well	RB
cord-001835-0s7ok4uw	3453	9	as	as	IN
cord-001835-0s7ok4uw	3453	10	the	the	DT
cord-001835-0s7ok4uw	3453	11	negative	negative	JJ
cord-001835-0s7ok4uw	3453	12	stain	stain	NN
cord-001835-0s7ok4uw	3453	13	and	and	CC
cord-001835-0s7ok4uw	3453	14	cryo	cryo	NN
cord-001835-0s7ok4uw	3453	15	-	-	HYPH
cord-001835-0s7ok4uw	3453	16	EM	EM	NNP
cord-001835-0s7ok4uw	3453	17	data	datum	NNS
cord-001835-0s7ok4uw	3453	18	will	will	MD
cord-001835-0s7ok4uw	3453	19	be	be	VB
cord-001835-0s7ok4uw	3453	20	will	will	MD
cord-001835-0s7ok4uw	3453	21	be	be	VB
cord-001835-0s7ok4uw	3453	22	presented	present	VBN
cord-001835-0s7ok4uw	3453	23	and	and	CC
cord-001835-0s7ok4uw	3453	24	discussed	discuss	VBN
cord-001835-0s7ok4uw	3453	25	.	.	.
cord-001835-0s7ok4uw	3454	1	Parametric	parametric	JJ
cord-001835-0s7ok4uw	3454	2	design	design	NN
cord-001835-0s7ok4uw	3454	3	of	of	IN
cord-001835-0s7ok4uw	3454	4	alpha	alpha	JJ
cord-001835-0s7ok4uw	3454	5	-	-	HYPH
cord-001835-0s7ok4uw	3454	6	helical	helical	JJ
cord-001835-0s7ok4uw	3454	7	barrels	barrel	NNS
cord-001835-0s7ok4uw	3454	8	and	and	CC
cord-001835-0s7ok4uw	3454	9	pore	pore	NN
cord-001835-0s7ok4uw	3454	10	-	-	HYPH
cord-001835-0s7ok4uw	3454	11	like	like	JJ
cord-001835-0s7ok4uw	3454	12	assemblies	assembly	NNS
cord-001835-0s7ok4uw	3454	13	with	with	IN
cord-001835-0s7ok4uw	3454	14	very	very	RB
cord-001835-0s7ok4uw	3454	15	high	high	JJ
cord-001835-0s7ok4uw	3454	16	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	3454	17	stabilities	stability	NNS
cord-001835-0s7ok4uw	3454	18	Computational	computational	JJ
cord-001835-0s7ok4uw	3454	19	design	design	NN
cord-001835-0s7ok4uw	3454	20	of	of	IN
cord-001835-0s7ok4uw	3454	21	novel	novel	JJ
cord-001835-0s7ok4uw	3454	22	protein	protein	NN
cord-001835-0s7ok4uw	3454	23	structures	structure	NNS
cord-001835-0s7ok4uw	3454	24	and	and	CC
cord-001835-0s7ok4uw	3454	25	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3454	26	with	with	IN
cord-001835-0s7ok4uw	3454	27	new	new	JJ
cord-001835-0s7ok4uw	3454	28	functions	function	NNS
cord-001835-0s7ok4uw	3454	29	is	be	VBZ
cord-001835-0s7ok4uw	3454	30	a	a	DT
cord-001835-0s7ok4uw	3454	31	promising	promising	JJ
cord-001835-0s7ok4uw	3454	32	tool	tool	NN
cord-001835-0s7ok4uw	3454	33	to	to	TO
cord-001835-0s7ok4uw	3454	34	create	create	VB
cord-001835-0s7ok4uw	3454	35	superior	superior	JJ
cord-001835-0s7ok4uw	3454	36	biological	biological	JJ
cord-001835-0s7ok4uw	3454	37	materials	material	NNS
cord-001835-0s7ok4uw	3454	38	with	with	IN
cord-001835-0s7ok4uw	3454	39	tailor	tailor	NN
cord-001835-0s7ok4uw	3454	40	-	-	HYPH
cord-001835-0s7ok4uw	3454	41	made	make	VBN
cord-001835-0s7ok4uw	3454	42	properties	property	NNS
cord-001835-0s7ok4uw	3454	43	,	,	,
cord-001835-0s7ok4uw	3454	44	new	new	JJ
cord-001835-0s7ok4uw	3454	45	pharmaceuticals	pharmaceutical	NNS
cord-001835-0s7ok4uw	3454	46	,	,	,
cord-001835-0s7ok4uw	3454	47	complex	complex	JJ
cord-001835-0s7ok4uw	3454	48	fine	fine	JJ
cord-001835-0s7ok4uw	3454	49	chemicals	chemical	NNS
cord-001835-0s7ok4uw	3454	50	or	or	CC
cord-001835-0s7ok4uw	3454	51	renewable	renewable	JJ
cord-001835-0s7ok4uw	3454	52	fuels	fuel	NNS
cord-001835-0s7ok4uw	3454	53	.	.	.
cord-001835-0s7ok4uw	3455	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3455	2	also	also	RB
cord-001835-0s7ok4uw	3455	3	challenges	challenge	VBZ
cord-001835-0s7ok4uw	3455	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3455	5	understanding	understanding	NN
cord-001835-0s7ok4uw	3455	6	of	of	IN
cord-001835-0s7ok4uw	3455	7	protein	protein	NN
cord-001835-0s7ok4uw	3455	8	folding	folding	NN
cord-001835-0s7ok4uw	3455	9	,	,	,
cord-001835-0s7ok4uw	3455	10	protein	protein	NN
cord-001835-0s7ok4uw	3455	11	evolution	evolution	NN
cord-001835-0s7ok4uw	3455	12	,	,	,
cord-001835-0s7ok4uw	3455	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	3455	14	recognition	recognition	NN
cord-001835-0s7ok4uw	3455	15	and	and	CC
cord-001835-0s7ok4uw	3455	16	catalysis	catalysis	NN
cord-001835-0s7ok4uw	3455	17	.	.	.
cord-001835-0s7ok4uw	3456	1	Here	here	RB
cord-001835-0s7ok4uw	3456	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3456	3	present	present	VBP
cord-001835-0s7ok4uw	3456	4	a	a	DT
cord-001835-0s7ok4uw	3456	5	procedure	procedure	NN
cord-001835-0s7ok4uw	3456	6	for	for	IN
cord-001835-0s7ok4uw	3456	7	designing	design	VBG
cord-001835-0s7ok4uw	3456	8	proteins	protein	NNS
cord-001835-0s7ok4uw	3456	9	with	with	IN
cord-001835-0s7ok4uw	3456	10	backbones	backbone	NNS
cord-001835-0s7ok4uw	3456	11	produced	produce	VBN
cord-001835-0s7ok4uw	3456	12	by	by	IN
cord-001835-0s7ok4uw	3456	13	varying	vary	VBG
cord-001835-0s7ok4uw	3456	14	the	the	DT
cord-001835-0s7ok4uw	3456	15	parameters	parameter	NNS
cord-001835-0s7ok4uw	3456	16	in	in	IN
cord-001835-0s7ok4uw	3456	17	the	the	DT
cord-001835-0s7ok4uw	3456	18	Crick	Crick	NNP
cord-001835-0s7ok4uw	3456	19	coiled	coiled	JJ
cord-001835-0s7ok4uw	3456	20	-	-	HYPH
cord-001835-0s7ok4uw	3456	21	coil	coil	NN
cord-001835-0s7ok4uw	3456	22	generating	generating	NN
cord-001835-0s7ok4uw	3456	23	equations	equation	NNS
cord-001835-0s7ok4uw	3456	24	[	[	-LRB-
cord-001835-0s7ok4uw	3456	25	1	1	CD
cord-001835-0s7ok4uw	3456	26	]	]	-RRB-
cord-001835-0s7ok4uw	3456	27	.	.	.
cord-001835-0s7ok4uw	3457	1	Combinatorial	combinatorial	JJ
cord-001835-0s7ok4uw	3457	2	design	design	NN
cord-001835-0s7ok4uw	3457	3	calculations	calculation	NNS
cord-001835-0s7ok4uw	3457	4	using	use	VBG
cord-001835-0s7ok4uw	3457	5	the	the	DT
cord-001835-0s7ok4uw	3457	6	software	software	NN
cord-001835-0s7ok4uw	3457	7	suite	suite	NN
cord-001835-0s7ok4uw	3457	8	Rosetta	Rosetta	NNP
cord-001835-0s7ok4uw	3457	9	identify	identify	VB
cord-001835-0s7ok4uw	3457	10	low	low	JJ
cord-001835-0s7ok4uw	3457	11	energy	energy	NN
cord-001835-0s7ok4uw	3457	12	sequences	sequence	NNS
cord-001835-0s7ok4uw	3457	13	for	for	IN
cord-001835-0s7ok4uw	3457	14	alternative	alternative	JJ
cord-001835-0s7ok4uw	3457	15	helix	helix	NN
cord-001835-0s7ok4uw	3457	16	supercoil	supercoil	NN
cord-001835-0s7ok4uw	3457	17	arrangements	arrangement	NNS
cord-001835-0s7ok4uw	3457	18	.	.	.
cord-001835-0s7ok4uw	3458	1	After	after	IN
cord-001835-0s7ok4uw	3458	2	that	that	DT
cord-001835-0s7ok4uw	3458	3	,	,	,
cord-001835-0s7ok4uw	3458	4	loop	loop	NN
cord-001835-0s7ok4uw	3458	5	modeling	modeling	NN
cord-001835-0s7ok4uw	3458	6	is	be	VBZ
cord-001835-0s7ok4uw	3458	7	applied	apply	VBN
cord-001835-0s7ok4uw	3458	8	to	to	TO
cord-001835-0s7ok4uw	3458	9	connect	connect	VB
cord-001835-0s7ok4uw	3458	10	the	the	DT
cord-001835-0s7ok4uw	3458	11	designs	design	NNS
cord-001835-0s7ok4uw	3458	12	with	with	IN
cord-001835-0s7ok4uw	3458	13	lowest	low	JJS
cord-001835-0s7ok4uw	3458	14	energy	energy	NN
cord-001835-0s7ok4uw	3458	15	.	.	.
cord-001835-0s7ok4uw	3459	1	The	the	DT
cord-001835-0s7ok4uw	3459	2	extent	extent	NN
cord-001835-0s7ok4uw	3459	3	to	to	TO
cord-001835-0s7ok4uw	3459	4	which	which	WDT
cord-001835-0s7ok4uw	3459	5	the	the	DT
cord-001835-0s7ok4uw	3459	6	designed	design	VBN
cord-001835-0s7ok4uw	3459	7	sequences	sequence	NNS
cord-001835-0s7ok4uw	3459	8	encode	encode	VBP
cord-001835-0s7ok4uw	3459	9	the	the	DT
cord-001835-0s7ok4uw	3459	10	designed	design	VBN
cord-001835-0s7ok4uw	3459	11	structures	structure	NNS
cord-001835-0s7ok4uw	3459	12	is	be	VBZ
cord-001835-0s7ok4uw	3459	13	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	3459	14	using	use	VBG
cord-001835-0s7ok4uw	3459	15	large	large	JJ
cord-001835-0s7ok4uw	3459	16	-	-	HYPH
cord-001835-0s7ok4uw	3459	17	scale	scale	NN
cord-001835-0s7ok4uw	3459	18	structure	structure	NN
cord-001835-0s7ok4uw	3459	19	prediction	prediction	NN
cord-001835-0s7ok4uw	3459	20	calculations	calculation	NNS
cord-001835-0s7ok4uw	3459	21	,	,	,
cord-001835-0s7ok4uw	3459	22	as	as	RB
cord-001835-0s7ok4uw	3459	23	well	well	RB
cord-001835-0s7ok4uw	3459	24	as	as	IN
cord-001835-0s7ok4uw	3459	25	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	3459	26	and	and	CC
cord-001835-0s7ok4uw	3459	27	asymmetric	asymmetric	JJ
cord-001835-0s7ok4uw	3459	28	protein	protein	NN
cord-001835-0s7ok4uw	3459	29	-	-	HYPH
cord-001835-0s7ok4uw	3459	30	protein	protein	NN
cord-001835-0s7ok4uw	3459	31	docking	docking	NN
cord-001835-0s7ok4uw	3459	32	calculations	calculation	NNS
cord-001835-0s7ok4uw	3459	33	.	.	.
cord-001835-0s7ok4uw	3460	1	Subsequently	subsequently	RB
cord-001835-0s7ok4uw	3460	2	,	,	,
cord-001835-0s7ok4uw	3460	3	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3460	4	genes	gene	NNS
cord-001835-0s7ok4uw	3460	5	are	be	VBP
cord-001835-0s7ok4uw	3460	6	generated	generate	VBN
cord-001835-0s7ok4uw	3460	7	for	for	IN
cord-001835-0s7ok4uw	3460	8	sequences	sequence	NNS
cord-001835-0s7ok4uw	3460	9	that	that	WDT
cord-001835-0s7ok4uw	3460	10	converge	converge	VBP
cord-001835-0s7ok4uw	3460	11	strongly	strongly	RB
cord-001835-0s7ok4uw	3460	12	on	on	IN
cord-001835-0s7ok4uw	3460	13	the	the	DT
cord-001835-0s7ok4uw	3460	14	designed	design	VBN
cord-001835-0s7ok4uw	3460	15	structure	structure	NN
cord-001835-0s7ok4uw	3460	16	for	for	IN
cord-001835-0s7ok4uw	3460	17	experimental	experimental	JJ
cord-001835-0s7ok4uw	3460	18	characterization	characterization	NN
cord-001835-0s7ok4uw	3460	19	.	.	.
cord-001835-0s7ok4uw	3461	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3461	2	applied	apply	VBD
cord-001835-0s7ok4uw	3461	3	this	this	DT
cord-001835-0s7ok4uw	3461	4	approach	approach	NN
cord-001835-0s7ok4uw	3461	5	to	to	IN
cord-001835-0s7ok4uw	3461	6	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	3461	7	three	three	CD
cord-001835-0s7ok4uw	3461	8	and	and	CC
cord-001835-0s7ok4uw	3461	9	four	four	CD
cord-001835-0s7ok4uw	3461	10	helical	helical	JJ
cord-001835-0s7ok4uw	3461	11	bundle	bundle	NN
cord-001835-0s7ok4uw	3461	12	structures	structure	NNS
cord-001835-0s7ok4uw	3461	13	as	as	RB
cord-001835-0s7ok4uw	3461	14	well	well	RB
cord-001835-0s7ok4uw	3461	15	as	as	IN
cord-001835-0s7ok4uw	3461	16	a	a	DT
cord-001835-0s7ok4uw	3461	17	pentameric	pentameric	JJ
cord-001835-0s7ok4uw	3461	18	five	five	CD
cord-001835-0s7ok4uw	3461	19	-	-	HYPH
cord-001835-0s7ok4uw	3461	20	helix	helix	NN
cord-001835-0s7ok4uw	3461	21	bundle	bundle	NN
cord-001835-0s7ok4uw	3461	22	structure	structure	NN
cord-001835-0s7ok4uw	3461	23	using	use	VBG
cord-001835-0s7ok4uw	3461	24	idealized	idealized	JJ
cord-001835-0s7ok4uw	3461	25	coiled	coiled	JJ
cord-001835-0s7ok4uw	3461	26	-	-	HYPH
cord-001835-0s7ok4uw	3461	27	coil	coil	NN
cord-001835-0s7ok4uw	3461	28	geometries	geometry	NNS
cord-001835-0s7ok4uw	3461	29	[	[	-LRB-
cord-001835-0s7ok4uw	3461	30	2	2	CD
cord-001835-0s7ok4uw	3461	31	]	]	-RRB-
cord-001835-0s7ok4uw	3461	32	.	.	.
cord-001835-0s7ok4uw	3462	1	Recently	recently	RB
cord-001835-0s7ok4uw	3462	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3462	3	expanded	expand	VBD
cord-001835-0s7ok4uw	3462	4	this	this	DT
cord-001835-0s7ok4uw	3462	5	approach	approach	NN
cord-001835-0s7ok4uw	3462	6	to	to	IN
cord-001835-0s7ok4uw	3462	7	higher	high	JJR
cord-001835-0s7ok4uw	3462	8	complexity	complexity	NN
cord-001835-0s7ok4uw	3462	9	backbones	backbone	NNS
cord-001835-0s7ok4uw	3462	10	,	,	,
cord-001835-0s7ok4uw	3462	11	which	which	WDT
cord-001835-0s7ok4uw	3462	12	resulted	result	VBD
cord-001835-0s7ok4uw	3462	13	in	in	IN
cord-001835-0s7ok4uw	3462	14	the	the	DT
cord-001835-0s7ok4uw	3462	15	de	de	JJ
cord-001835-0s7ok4uw	3462	16	-	-	JJ
cord-001835-0s7ok4uw	3462	17	novo	novo	JJ
cord-001835-0s7ok4uw	3462	18	design	design	NN
cord-001835-0s7ok4uw	3462	19	of	of	IN
cord-001835-0s7ok4uw	3462	20	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	3462	21	,	,	,
cord-001835-0s7ok4uw	3462	22	antiparallel	antiparallel	RB
cord-001835-0s7ok4uw	3462	23	six	six	CD
cord-001835-0s7ok4uw	3462	24	-	-	HYPH
cord-001835-0s7ok4uw	3462	25	helix	helix	NN
cord-001835-0s7ok4uw	3462	26	bundles	bundle	NNS
cord-001835-0s7ok4uw	3462	27	with	with	IN
cord-001835-0s7ok4uw	3462	28	untwisted	untwisted	JJ
cord-001835-0s7ok4uw	3462	29	,	,	,
cord-001835-0s7ok4uw	3462	30	left	leave	VBN
cord-001835-0s7ok4uw	3462	31	-	-	HYPH
cord-001835-0s7ok4uw	3462	32	and	and	CC
cord-001835-0s7ok4uw	3462	33	right	right	RB
cord-001835-0s7ok4uw	3462	34	-	-	HYPH
cord-001835-0s7ok4uw	3462	35	handed	handed	JJ
cord-001835-0s7ok4uw	3462	36	geometries	geometry	NNS
cord-001835-0s7ok4uw	3462	37	.	.	.
cord-001835-0s7ok4uw	3463	1	Circular	Circular	NNP
cord-001835-0s7ok4uw	3463	2	Dichroism	Dichroism	NNP
cord-001835-0s7ok4uw	3463	3	(	(	-LRB-
cord-001835-0s7ok4uw	3463	4	CD	CD	NNP
cord-001835-0s7ok4uw	3463	5	)	)	-RRB-
cord-001835-0s7ok4uw	3463	6	,	,	,
cord-001835-0s7ok4uw	3463	7	Size	size	NN
cord-001835-0s7ok4uw	3463	8	-	-	HYPH
cord-001835-0s7ok4uw	3463	9	exclusion	exclusion	NN
cord-001835-0s7ok4uw	3463	10	coupled	couple	VBN
cord-001835-0s7ok4uw	3463	11	Multi	Multi	NNP
cord-001835-0s7ok4uw	3463	12	-	-	HYPH
cord-001835-0s7ok4uw	3463	13	Angle	Angle	NNP
cord-001835-0s7ok4uw	3463	14	Light	Light	NNP
cord-001835-0s7ok4uw	3463	15	Scattering	scattering	NN
cord-001835-0s7ok4uw	3463	16	measurements	measurement	NNS
cord-001835-0s7ok4uw	3463	17	(	(	-LRB-
cord-001835-0s7ok4uw	3463	18	SEC	SEC	NNP
cord-001835-0s7ok4uw	3463	19	-	-	HYPH
cord-001835-0s7ok4uw	3463	20	MALS	MALS	NNP
cord-001835-0s7ok4uw	3463	21	)	)	-RRB-
cord-001835-0s7ok4uw	3463	22	,	,	,
cord-001835-0s7ok4uw	3463	23	negative	negative	JJ
cord-001835-0s7ok4uw	3463	24	stain	stain	NN
cord-001835-0s7ok4uw	3463	25	electron	electron	NN
cord-001835-0s7ok4uw	3463	26	micrographs	micrograph	NNS
cord-001835-0s7ok4uw	3463	27	(	(	-LRB-
cord-001835-0s7ok4uw	3463	28	EM	EM	NNP
cord-001835-0s7ok4uw	3463	29	)	)	-RRB-
cord-001835-0s7ok4uw	3463	30	and	and	CC
cord-001835-0s7ok4uw	3463	31	Small	Small	NNP
cord-001835-0s7ok4uw	3463	32	Angle	Angle	NNP
cord-001835-0s7ok4uw	3463	33	X	x	NN
cord-001835-0s7ok4uw	3463	34	-	-	NN
cord-001835-0s7ok4uw	3463	35	ray	ray	NN
cord-001835-0s7ok4uw	3463	36	Scattering	scattering	NN
cord-001835-0s7ok4uw	3463	37	(	(	-LRB-
cord-001835-0s7ok4uw	3463	38	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	3463	39	)	)	-RRB-
cord-001835-0s7ok4uw	3463	40	of	of	IN
cord-001835-0s7ok4uw	3463	41	these	these	DT
cord-001835-0s7ok4uw	3463	42	designs	design	NNS
cord-001835-0s7ok4uw	3463	43	suggest	suggest	VBP
cord-001835-0s7ok4uw	3463	44	that	that	IN
cord-001835-0s7ok4uw	3463	45	they	-PRON-	PRP
cord-001835-0s7ok4uw	3463	46	indeed	indeed	RB
cord-001835-0s7ok4uw	3463	47	form	form	VBP
cord-001835-0s7ok4uw	3463	48	the	the	DT
cord-001835-0s7ok4uw	3463	49	designed	design	VBN
cord-001835-0s7ok4uw	3463	50	structures	structure	NNS
cord-001835-0s7ok4uw	3463	51	.	.	.
cord-001835-0s7ok4uw	3464	1	In	in	IN
cord-001835-0s7ok4uw	3464	2	addition	addition	NN
cord-001835-0s7ok4uw	3464	3	,	,	,
cord-001835-0s7ok4uw	3464	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3464	5	used	use	VBD
cord-001835-0s7ok4uw	3464	6	Rosetta	Rosetta	NNP
cord-001835-0s7ok4uw	3464	7	protein	protein	NN
cord-001835-0s7ok4uw	3464	8	-	-	HYPH
cord-001835-0s7ok4uw	3464	9	protein	protein	NN
cord-001835-0s7ok4uw	3464	10	interface	interface	NN
cord-001835-0s7ok4uw	3464	11	design	design	NN
cord-001835-0s7ok4uw	3464	12	functionality	functionality	NN
cord-001835-0s7ok4uw	3464	13	to	to	TO
cord-001835-0s7ok4uw	3464	14	computationally	computationally	RB
cord-001835-0s7ok4uw	3464	15	design	design	VB
cord-001835-0s7ok4uw	3464	16	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	3464	17	out	out	IN
cord-001835-0s7ok4uw	3464	18	of	of	IN
cord-001835-0s7ok4uw	3464	19	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3464	20	previously	previously	RB
cord-001835-0s7ok4uw	3464	21	published	publish	VBN
cord-001835-0s7ok4uw	3464	22	three	three	CD
cord-001835-0s7ok4uw	3464	23	and	and	CC
cord-001835-0s7ok4uw	3464	24	four	four	CD
cord-001835-0s7ok4uw	3464	25	helix	helix	NN
cord-001835-0s7ok4uw	3464	26	bundle	bundle	NN
cord-001835-0s7ok4uw	3464	27	structures	structure	NNS
cord-001835-0s7ok4uw	3464	28	to	to	TO
cord-001835-0s7ok4uw	3464	29	generate	generate	VB
cord-001835-0s7ok4uw	3464	30	self	self	NN
cord-001835-0s7ok4uw	3464	31	-	-	HYPH
cord-001835-0s7ok4uw	3464	32	assembling	assemble	VBG
cord-001835-0s7ok4uw	3464	33	pore	pore	NN
cord-001835-0s7ok4uw	3464	34	-	-	HYPH
cord-001835-0s7ok4uw	3464	35	like	like	JJ
cord-001835-0s7ok4uw	3464	36	structures	structure	NNS
cord-001835-0s7ok4uw	3464	37	with	with	IN
cord-001835-0s7ok4uw	3464	38	the	the	DT
cord-001835-0s7ok4uw	3464	39	potential	potential	JJ
cord-001835-0s7ok4uw	3464	40	use	use	NN
cord-001835-0s7ok4uw	3464	41	as	as	IN
cord-001835-0s7ok4uw	3464	42	channels	channel	NNS
cord-001835-0s7ok4uw	3464	43	or	or	CC
cord-001835-0s7ok4uw	3464	44	transporters	transporter	NNS
cord-001835-0s7ok4uw	3464	45	.	.	.
cord-001835-0s7ok4uw	3465	1	Again	again	RB
cord-001835-0s7ok4uw	3465	2	,	,	,
cord-001835-0s7ok4uw	3465	3	experimental	experimental	JJ
cord-001835-0s7ok4uw	3465	4	validation	validation	NN
cord-001835-0s7ok4uw	3465	5	of	of	IN
cord-001835-0s7ok4uw	3465	6	these	these	DT
cord-001835-0s7ok4uw	3465	7	designs	design	NNS
cord-001835-0s7ok4uw	3465	8	by	by	IN
cord-001835-0s7ok4uw	3465	9	CD	CD	NNP
cord-001835-0s7ok4uw	3465	10	,	,	,
cord-001835-0s7ok4uw	3465	11	SEC	SEC	NNP
cord-001835-0s7ok4uw	3465	12	-	-	HYPH
cord-001835-0s7ok4uw	3465	13	MALS	MALS	NNP
cord-001835-0s7ok4uw	3465	14	,	,	,
cord-001835-0s7ok4uw	3465	15	EM	EM	NNP
cord-001835-0s7ok4uw	3465	16	and	and	CC
cord-001835-0s7ok4uw	3465	17	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	3465	18	show	show	VBP
cord-001835-0s7ok4uw	3465	19	that	that	IN
cord-001835-0s7ok4uw	3465	20	the	the	DT
cord-001835-0s7ok4uw	3465	21	designs	design	NNS
cord-001835-0s7ok4uw	3465	22	are	be	VBP
cord-001835-0s7ok4uw	3465	23	correct	correct	JJ
cord-001835-0s7ok4uw	3465	24	.	.	.
cord-001835-0s7ok4uw	3466	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3466	2	are	be	VBP
cord-001835-0s7ok4uw	3466	3	currently	currently	RB
cord-001835-0s7ok4uw	3466	4	undertaking	undertake	VBG
cord-001835-0s7ok4uw	3466	5	further	further	JJ
cord-001835-0s7ok4uw	3466	6	structural	structural	JJ
cord-001835-0s7ok4uw	3466	7	investigation	investigation	NN
cord-001835-0s7ok4uw	3466	8	of	of	IN
cord-001835-0s7ok4uw	3466	9	all	all	PDT
cord-001835-0s7ok4uw	3466	10	these	these	DT
cord-001835-0s7ok4uw	3466	11	designs	design	NNS
cord-001835-0s7ok4uw	3466	12	by	by	IN
cord-001835-0s7ok4uw	3466	13	X	x	NN
cord-001835-0s7ok4uw	3466	14	-	-	NN
cord-001835-0s7ok4uw	3466	15	ray	ray	JJ
cord-001835-0s7ok4uw	3466	16	crystallography	crystallography	NN
cord-001835-0s7ok4uw	3466	17	.	.	.
cord-001835-0s7ok4uw	3467	1	The	the	DT
cord-001835-0s7ok4uw	3467	2	designs	design	NNS
cord-001835-0s7ok4uw	3467	3	described	describe	VBN
cord-001835-0s7ok4uw	3467	4	above	above	RB
cord-001835-0s7ok4uw	3467	5	can	can	MD
cord-001835-0s7ok4uw	3467	6	act	act	VB
cord-001835-0s7ok4uw	3467	7	as	as	IN
cord-001835-0s7ok4uw	3467	8	templates	template	NNS
cord-001835-0s7ok4uw	3467	9	for	for	IN
cord-001835-0s7ok4uw	3467	10	protein	protein	NN
cord-001835-0s7ok4uw	3467	11	or	or	CC
cord-001835-0s7ok4uw	3467	12	small	small	JJ
cord-001835-0s7ok4uw	3467	13	molecule	molecule	NN
cord-001835-0s7ok4uw	3467	14	binding	binding	NN
cord-001835-0s7ok4uw	3467	15	,	,	,
cord-001835-0s7ok4uw	3467	16	holding	hold	VBG
cord-001835-0s7ok4uw	3467	17	a	a	DT
cord-001835-0s7ok4uw	3467	18	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3467	19	machinery	machinery	NN
cord-001835-0s7ok4uw	3467	20	or	or	CC
cord-001835-0s7ok4uw	3467	21	for	for	IN
cord-001835-0s7ok4uw	3467	22	scaffolding	scaffold	VBG
cord-001835-0s7ok4uw	3467	23	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3467	24	in	in	IN
cord-001835-0s7ok4uw	3467	25	reaction	reaction	NN
cord-001835-0s7ok4uw	3467	26	cascades	cascade	NNS
cord-001835-0s7ok4uw	3467	27	.	.	.
cord-001835-0s7ok4uw	3468	1	Some	some	DT
cord-001835-0s7ok4uw	3468	2	of	of	IN
cord-001835-0s7ok4uw	3468	3	these	these	DT
cord-001835-0s7ok4uw	3468	4	applications	application	NNS
cord-001835-0s7ok4uw	3468	5	are	be	VBP
cord-001835-0s7ok4uw	3468	6	currently	currently	RB
cord-001835-0s7ok4uw	3468	7	under	under	IN
cord-001835-0s7ok4uw	3468	8	investigation	investigation	NN
cord-001835-0s7ok4uw	3468	9	,	,	,
cord-001835-0s7ok4uw	3468	10	including	include	VBG
cord-001835-0s7ok4uw	3468	11	a	a	DT
cord-001835-0s7ok4uw	3468	12	self	self	NN
cord-001835-0s7ok4uw	3468	13	-	-	HYPH
cord-001835-0s7ok4uw	3468	14	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	3468	15	redox	redox	NN
cord-001835-0s7ok4uw	3468	16	system	system	NN
cord-001835-0s7ok4uw	3468	17	employing	employ	VBG
cord-001835-0s7ok4uw	3468	18	two	two	CD
cord-001835-0s7ok4uw	3468	19	copper	copper	NN
cord-001835-0s7ok4uw	3468	20	-	-	HYPH
cord-001835-0s7ok4uw	3468	21	centers	center	NNS
cord-001835-0s7ok4uw	3468	22	,	,	,
cord-001835-0s7ok4uw	3468	23	binding	bind	VBG
cord-001835-0s7ok4uw	3468	24	of	of	IN
cord-001835-0s7ok4uw	3468	25	heme	heme	NN
cord-001835-0s7ok4uw	3468	26	-	-	HYPH
cord-001835-0s7ok4uw	3468	27	moieties	moiety	NNS
cord-001835-0s7ok4uw	3468	28	as	as	IN
cord-001835-0s7ok4uw	3468	29	a	a	DT
cord-001835-0s7ok4uw	3468	30	prosthetic	prosthetic	JJ
cord-001835-0s7ok4uw	3468	31	group	group	NN
cord-001835-0s7ok4uw	3468	32	and	and	CC
cord-001835-0s7ok4uw	3468	33	tailoring	tailor	VBG
cord-001835-0s7ok4uw	3468	34	the	the	DT
cord-001835-0s7ok4uw	3468	35	pore	pore	NN
cord-001835-0s7ok4uw	3468	36	-	-	HYPH
cord-001835-0s7ok4uw	3468	37	like	like	JJ
cord-001835-0s7ok4uw	3468	38	geometries	geometry	NNS
cord-001835-0s7ok4uw	3468	39	to	to	TO
cord-001835-0s7ok4uw	3468	40	be	be	VB
cord-001835-0s7ok4uw	3468	41	used	use	VBN
cord-001835-0s7ok4uw	3468	42	in	in	IN
cord-001835-0s7ok4uw	3468	43	nanopore	nanopore	JJ
cord-001835-0s7ok4uw	3468	44	sequencing	sequencing	NN
cord-001835-0s7ok4uw	3468	45	.	.	.
cord-001835-0s7ok4uw	3469	1	University	University	NNP
cord-001835-0s7ok4uw	3469	2	of	of	IN
cord-001835-0s7ok4uw	3469	3	Washington	Washington	NNP
cord-001835-0s7ok4uw	3469	4	,	,	,
cord-001835-0s7ok4uw	3469	5	2	2	CD
cord-001835-0s7ok4uw	3469	6	University	University	NNP
cord-001835-0s7ok4uw	3469	7	of	of	IN
cord-001835-0s7ok4uw	3469	8	California	California	NNP
cord-001835-0s7ok4uw	3469	9	,	,	,
cord-001835-0s7ok4uw	3469	10	San	San	NNP
cord-001835-0s7ok4uw	3469	11	Francisco	Francisco	NNP
cord-001835-0s7ok4uw	3469	12	,	,	,
cord-001835-0s7ok4uw	3469	13	3	3	CD
cord-001835-0s7ok4uw	3469	14	 	 	_SP
cord-001835-0s7ok4uw	3469	15	Repeat	repeat	NN
cord-001835-0s7ok4uw	3469	16	proteins	protein	NNS
cord-001835-0s7ok4uw	3469	17	are	be	VBP
cord-001835-0s7ok4uw	3469	18	an	an	DT
cord-001835-0s7ok4uw	3469	19	example	example	NN
cord-001835-0s7ok4uw	3469	20	of	of	IN
cord-001835-0s7ok4uw	3469	21	how	how	WRB
cord-001835-0s7ok4uw	3469	22	evolution	evolution	NN
cord-001835-0s7ok4uw	3469	23	proceeds	proceed	NNS
cord-001835-0s7ok4uw	3469	24	by	by	IN
cord-001835-0s7ok4uw	3469	25	building	build	VBG
cord-001835-0s7ok4uw	3469	26	on	on	IN
cord-001835-0s7ok4uw	3469	27	existing	exist	VBG
cord-001835-0s7ok4uw	3469	28	structures	structure	NNS
cord-001835-0s7ok4uw	3469	29	and	and	CC
cord-001835-0s7ok4uw	3469	30	functions	function	NNS
cord-001835-0s7ok4uw	3469	31	,	,	,
cord-001835-0s7ok4uw	3469	32	but	but	CC
cord-001835-0s7ok4uw	3469	33	also	also	RB
cord-001835-0s7ok4uw	3469	34	a	a	DT
cord-001835-0s7ok4uw	3469	35	source	source	NN
cord-001835-0s7ok4uw	3469	36	of	of	IN
cord-001835-0s7ok4uw	3469	37	modular	modular	JJ
cord-001835-0s7ok4uw	3469	38	protein	protein	NN
cord-001835-0s7ok4uw	3469	39	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3469	40	for	for	IN
cord-001835-0s7ok4uw	3469	41	molecular	molecular	JJ
cord-001835-0s7ok4uw	3469	42	recognition	recognition	NN
cord-001835-0s7ok4uw	3469	43	and	and	CC
cord-001835-0s7ok4uw	3469	44	biomaterials	biomaterial	NNS
cord-001835-0s7ok4uw	3469	45	.	.	.
cord-001835-0s7ok4uw	3470	1	However	however	RB
cord-001835-0s7ok4uw	3470	2	,	,	,
cord-001835-0s7ok4uw	3470	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	3470	4	is	be	VBZ
cord-001835-0s7ok4uw	3470	5	unclear	unclear	JJ
cord-001835-0s7ok4uw	3470	6	whether	whether	IN
cord-001835-0s7ok4uw	3470	7	the	the	DT
cord-001835-0s7ok4uw	3470	8	limited	limited	JJ
cord-001835-0s7ok4uw	3470	9	number	number	NN
cord-001835-0s7ok4uw	3470	10	of	of	IN
cord-001835-0s7ok4uw	3470	11	folds	fold	NNS
cord-001835-0s7ok4uw	3470	12	and	and	CC
cord-001835-0s7ok4uw	3470	13	families	family	NNS
cord-001835-0s7ok4uw	3470	14	that	that	WDT
cord-001835-0s7ok4uw	3470	15	we	-PRON-	PRP
cord-001835-0s7ok4uw	3470	16	know	know	VBP
cord-001835-0s7ok4uw	3470	17	today	today	NN
cord-001835-0s7ok4uw	3470	18	is	be	VBZ
cord-001835-0s7ok4uw	3470	19	the	the	DT
cord-001835-0s7ok4uw	3470	20	result	result	NN
cord-001835-0s7ok4uw	3470	21	of	of	IN
cord-001835-0s7ok4uw	3470	22	the	the	DT
cord-001835-0s7ok4uw	3470	23	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	3470	24	limitations	limitation	NNS
cord-001835-0s7ok4uw	3470	25	of	of	IN
cord-001835-0s7ok4uw	3470	26	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	3470	27	chains	chain	NNS
cord-001835-0s7ok4uw	3470	28	or	or	CC
cord-001835-0s7ok4uw	3470	29	the	the	DT
cord-001835-0s7ok4uw	3470	30	consequence	consequence	NN
cord-001835-0s7ok4uw	3470	31	of	of	IN
cord-001835-0s7ok4uw	3470	32	the	the	DT
cord-001835-0s7ok4uw	3470	33	path	path	NN
cord-001835-0s7ok4uw	3470	34	followed	follow	VBN
cord-001835-0s7ok4uw	3470	35	by	by	IN
cord-001835-0s7ok4uw	3470	36	evolution	evolution	NN
cord-001835-0s7ok4uw	3470	37	.	.	.
cord-001835-0s7ok4uw	3471	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3471	2	explored	explore	VBD
cord-001835-0s7ok4uw	3471	3	this	this	DT
cord-001835-0s7ok4uw	3471	4	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	3471	5	by	by	IN
cord-001835-0s7ok4uw	3471	6	computational	computational	JJ
cord-001835-0s7ok4uw	3471	7	design	design	NN
cord-001835-0s7ok4uw	3471	8	of	of	IN
cord-001835-0s7ok4uw	3471	9	repeat	repeat	NN
cord-001835-0s7ok4uw	3471	10	proteins	protein	NNS
cord-001835-0s7ok4uw	3471	11	based	base	VBN
cord-001835-0s7ok4uw	3471	12	on	on	IN
cord-001835-0s7ok4uw	3471	13	modular	modular	JJ
cord-001835-0s7ok4uw	3471	14	units	unit	NNS
cord-001835-0s7ok4uw	3471	15	formed	form	VBN
cord-001835-0s7ok4uw	3471	16	by	by	IN
cord-001835-0s7ok4uw	3471	17	two	two	CD
cord-001835-0s7ok4uw	3471	18	alpha	alpha	NN
cord-001835-0s7ok4uw	3471	19	helices	helix	NNS
cord-001835-0s7ok4uw	3471	20	and	and	CC
cord-001835-0s7ok4uw	3471	21	two	two	CD
cord-001835-0s7ok4uw	3471	22	loops	loop	NNS
cord-001835-0s7ok4uw	3471	23	of	of	IN
cord-001835-0s7ok4uw	3471	24	variable	variable	JJ
cord-001835-0s7ok4uw	3471	25	lengths	length	NNS
cord-001835-0s7ok4uw	3471	26	,	,	,
cord-001835-0s7ok4uw	3471	27	without	without	IN
cord-001835-0s7ok4uw	3471	28	relying	rely	VBG
cord-001835-0s7ok4uw	3471	29	on	on	IN
cord-001835-0s7ok4uw	3471	30	information	information	NN
cord-001835-0s7ok4uw	3471	31	from	from	IN
cord-001835-0s7ok4uw	3471	32	available	available	JJ
cord-001835-0s7ok4uw	3471	33	repeat	repeat	NN
cord-001835-0s7ok4uw	3471	34	protein	protein	NN
cord-001835-0s7ok4uw	3471	35	families	family	NNS
cord-001835-0s7ok4uw	3471	36	.	.	.
cord-001835-0s7ok4uw	3472	1	The	the	DT
cord-001835-0s7ok4uw	3472	2	automated	automate	VBN
cord-001835-0s7ok4uw	3472	3	sampling	sampling	NN
cord-001835-0s7ok4uw	3472	4	of	of	IN
cord-001835-0s7ok4uw	3472	5	the	the	DT
cord-001835-0s7ok4uw	3472	6	conformational	conformational	JJ
cord-001835-0s7ok4uw	3472	7	space	space	NN
cord-001835-0s7ok4uw	3472	8	resulted	result	VBD
cord-001835-0s7ok4uw	3472	9	in	in	IN
cord-001835-0s7ok4uw	3472	10	a	a	DT
cord-001835-0s7ok4uw	3472	11	large	large	JJ
cord-001835-0s7ok4uw	3472	12	number	number	NN
cord-001835-0s7ok4uw	3472	13	of	of	IN
cord-001835-0s7ok4uw	3472	14	architectures	architecture	NNS
cord-001835-0s7ok4uw	3472	15	from	from	IN
cord-001835-0s7ok4uw	3472	16	which	which	WDT
cord-001835-0s7ok4uw	3472	17	83	83	CD
cord-001835-0s7ok4uw	3472	18	de	de	NNP
cord-001835-0s7ok4uw	3472	19	novo	novo	NNP
cord-001835-0s7ok4uw	3472	20	designs	design	NNS
cord-001835-0s7ok4uw	3472	21	were	be	VBD
cord-001835-0s7ok4uw	3472	22	selected	select	VBN
cord-001835-0s7ok4uw	3472	23	for	for	IN
cord-001835-0s7ok4uw	3472	24	experimental	experimental	JJ
cord-001835-0s7ok4uw	3472	25	characterization	characterization	NN
cord-001835-0s7ok4uw	3472	26	.	.	.
cord-001835-0s7ok4uw	3473	1	66	66	CD
cord-001835-0s7ok4uw	3473	2	%	%	NN
cord-001835-0s7ok4uw	3473	3	of	of	IN
cord-001835-0s7ok4uw	3473	4	the	the	DT
cord-001835-0s7ok4uw	3473	5	proteins	protein	NNS
cord-001835-0s7ok4uw	3473	6	were	be	VBD
cord-001835-0s7ok4uw	3473	7	stable	stable	JJ
cord-001835-0s7ok4uw	3473	8	up	up	IN
cord-001835-0s7ok4uw	3473	9	to	to	IN
cord-001835-0s7ok4uw	3473	10	958C	958c	CD
cord-001835-0s7ok4uw	3473	11	and	and	CC
cord-001835-0s7ok4uw	3473	12	monodisperse	monodisperse	NN
cord-001835-0s7ok4uw	3473	13	and	and	CC
cord-001835-0s7ok4uw	3473	14	42	42	CD
cord-001835-0s7ok4uw	3473	15	designs	design	NNS
cord-001835-0s7ok4uw	3473	16	were	be	VBD
cord-001835-0s7ok4uw	3473	17	structurally	structurally	RB
cord-001835-0s7ok4uw	3473	18	validated	validate	VBN
cord-001835-0s7ok4uw	3473	19	by	by	IN
cord-001835-0s7ok4uw	3473	20	small	small	JJ
cord-001835-0s7ok4uw	3473	21	angle	angle	NN
cord-001835-0s7ok4uw	3473	22	X	x	NN
cord-001835-0s7ok4uw	3473	23	-	-	NN
cord-001835-0s7ok4uw	3473	24	ray	ray	NN
cord-001835-0s7ok4uw	3473	25	scattering	scattering	NN
cord-001835-0s7ok4uw	3473	26	.	.	.
cord-001835-0s7ok4uw	3474	1	Crystal	crystal	NN
cord-001835-0s7ok4uw	3474	2	structures	structure	NNS
cord-001835-0s7ok4uw	3474	3	were	be	VBD
cord-001835-0s7ok4uw	3474	4	solved	solve	VBN
cord-001835-0s7ok4uw	3474	5	for	for	IN
cord-001835-0s7ok4uw	3474	6	15	15	CD
cord-001835-0s7ok4uw	3474	7	of	of	IN
cord-001835-0s7ok4uw	3474	8	them	-PRON-	PRP
cord-001835-0s7ok4uw	3474	9	,	,	,
cord-001835-0s7ok4uw	3474	10	with	with	IN
cord-001835-0s7ok4uw	3474	11	root	root	NN
cord-001835-0s7ok4uw	3474	12	mean	mean	VBP
cord-001835-0s7ok4uw	3474	13	square	square	JJ
cord-001835-0s7ok4uw	3474	14	deviation	deviation	NN
cord-001835-0s7ok4uw	3474	15	from	from	IN
cord-001835-0s7ok4uw	3474	16	the	the	DT
cord-001835-0s7ok4uw	3474	17	models	model	NNS
cord-001835-0s7ok4uw	3474	18	between	between	IN
cord-001835-0s7ok4uw	3474	19	0.7Å	0.7Å	NNS
cord-001835-0s7ok4uw	3474	20	and	and	CC
cord-001835-0s7ok4uw	3474	21	2.5Å.	2.5å.	CD
cord-001835-0s7ok4uw	3475	1	The	the	DT
cord-001835-0s7ok4uw	3475	2	designs	design	NNS
cord-001835-0s7ok4uw	3475	3	differ	differ	VBP
cord-001835-0s7ok4uw	3475	4	from	from	IN
cord-001835-0s7ok4uw	3475	5	known	know	VBN
cord-001835-0s7ok4uw	3475	6	proteins	protein	NNS
cord-001835-0s7ok4uw	3475	7	both	both	CC
cord-001835-0s7ok4uw	3475	8	at	at	IN
cord-001835-0s7ok4uw	3475	9	the	the	DT
cord-001835-0s7ok4uw	3475	10	sequence	sequence	NN
cord-001835-0s7ok4uw	3475	11	and	and	CC
cord-001835-0s7ok4uw	3475	12	structure	structure	NN
cord-001835-0s7ok4uw	3475	13	levels	level	NNS
cord-001835-0s7ok4uw	3475	14	and	and	CC
cord-001835-0s7ok4uw	3475	15	cover	cover	VB
cord-001835-0s7ok4uw	3475	16	a	a	DT
cord-001835-0s7ok4uw	3475	17	broader	broad	JJR
cord-001835-0s7ok4uw	3475	18	range	range	NN
cord-001835-0s7ok4uw	3475	19	of	of	IN
cord-001835-0s7ok4uw	3475	20	geometries	geometry	NNS
cord-001835-0s7ok4uw	3475	21	than	than	IN
cord-001835-0s7ok4uw	3475	22	observed	observe	VBN
cord-001835-0s7ok4uw	3475	23	in	in	IN
cord-001835-0s7ok4uw	3475	24	naturally	naturally	RB
cord-001835-0s7ok4uw	3475	25	occurring	occur	VBG
cord-001835-0s7ok4uw	3475	26	repeat	repeat	VBP
cord-001835-0s7ok4uw	3475	27	protein	protein	NN
cord-001835-0s7ok4uw	3475	28	families	family	NNS
cord-001835-0s7ok4uw	3475	29	,	,	,
cord-001835-0s7ok4uw	3475	30	indicating	indicate	VBG
cord-001835-0s7ok4uw	3475	31	that	that	IN
cord-001835-0s7ok4uw	3475	32	existing	exist	VBG
cord-001835-0s7ok4uw	3475	33	architectures	architecture	NNS
cord-001835-0s7ok4uw	3475	34	represent	represent	VBP
cord-001835-0s7ok4uw	3475	35	only	only	RB
cord-001835-0s7ok4uw	3475	36	a	a	DT
cord-001835-0s7ok4uw	3475	37	small	small	JJ
cord-001835-0s7ok4uw	3475	38	fraction	fraction	NN
cord-001835-0s7ok4uw	3475	39	of	of	IN
cord-001835-0s7ok4uw	3475	40	what	what	WP
cord-001835-0s7ok4uw	3475	41	can	can	MD
cord-001835-0s7ok4uw	3475	42	be	be	VB
cord-001835-0s7ok4uw	3475	43	achieved	achieve	VBN
cord-001835-0s7ok4uw	3475	44	.	.	.
cord-001835-0s7ok4uw	3476	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3476	2	results	result	NNS
cord-001835-0s7ok4uw	3476	3	show	show	VBP
cord-001835-0s7ok4uw	3476	4	that	that	IN
cord-001835-0s7ok4uw	3476	5	it	-PRON-	PRP
cord-001835-0s7ok4uw	3476	6	is	be	VBZ
cord-001835-0s7ok4uw	3476	7	possible	possible	JJ
cord-001835-0s7ok4uw	3476	8	to	to	TO
cord-001835-0s7ok4uw	3476	9	expand	expand	VB
cord-001835-0s7ok4uw	3476	10	the	the	DT
cord-001835-0s7ok4uw	3476	11	range	range	NN
cord-001835-0s7ok4uw	3476	12	of	of	IN
cord-001835-0s7ok4uw	3476	13	repeat	repeat	NN
cord-001835-0s7ok4uw	3476	14	protein	protein	NN
cord-001835-0s7ok4uw	3476	15	architectures	architecture	NNS
cord-001835-0s7ok4uw	3476	16	beyond	beyond	IN
cord-001835-0s7ok4uw	3476	17	the	the	DT
cord-001835-0s7ok4uw	3476	18	naturally	naturally	RB
cord-001835-0s7ok4uw	3476	19	occurring	occur	VBG
cord-001835-0s7ok4uw	3476	20	families	family	NNS
cord-001835-0s7ok4uw	3476	21	,	,	,
cord-001835-0s7ok4uw	3476	22	and	and	CC
cord-001835-0s7ok4uw	3476	23	that	that	IN
cord-001835-0s7ok4uw	3476	24	computational	computational	JJ
cord-001835-0s7ok4uw	3476	25	design	design	NN
cord-001835-0s7ok4uw	3476	26	can	can	MD
cord-001835-0s7ok4uw	3476	27	provide	provide	VB
cord-001835-0s7ok4uw	3476	28	new	new	JJ
cord-001835-0s7ok4uw	3476	29	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3476	30	and	and	CC
cord-001835-0s7ok4uw	3476	31	enable	enable	VB
cord-001835-0s7ok4uw	3476	32	the	the	DT
cord-001835-0s7ok4uw	3476	33	design	design	NN
cord-001835-0s7ok4uw	3476	34	of	of	IN
cord-001835-0s7ok4uw	3476	35	proteins	protein	NNS
cord-001835-0s7ok4uw	3476	36	tailored	tailor	VBN
cord-001835-0s7ok4uw	3476	37	for	for	IN
cord-001835-0s7ok4uw	3476	38	specific	specific	JJ
cord-001835-0s7ok4uw	3476	39	applications	application	NNS
cord-001835-0s7ok4uw	3476	40	.	.	.
cord-001835-0s7ok4uw	3477	1	The	the	DT
cord-001835-0s7ok4uw	3477	2	serpin	serpin	JJ
cord-001835-0s7ok4uw	3477	3	family	family	NN
cord-001835-0s7ok4uw	3477	4	of	of	IN
cord-001835-0s7ok4uw	3477	5	proteins	protein	NNS
cord-001835-0s7ok4uw	3477	6	consists	consist	VBZ
cord-001835-0s7ok4uw	3477	7	of	of	IN
cord-001835-0s7ok4uw	3477	8	over	over	IN
cord-001835-0s7ok4uw	3477	9	1500	1500	CD
cord-001835-0s7ok4uw	3477	10	members	member	NNS
cord-001835-0s7ok4uw	3477	11	,	,	,
cord-001835-0s7ok4uw	3477	12	all	all	RB
cord-001835-0s7ok4uw	3477	13	with	with	IN
cord-001835-0s7ok4uw	3477	14	a	a	DT
cord-001835-0s7ok4uw	3477	15	highly	highly	RB
cord-001835-0s7ok4uw	3477	16	conserved	conserve	VBN
cord-001835-0s7ok4uw	3477	17	native	native	JJ
cord-001835-0s7ok4uw	3477	18	structure	structure	NN
cord-001835-0s7ok4uw	3477	19	that	that	WDT
cord-001835-0s7ok4uw	3477	20	is	be	VBZ
cord-001835-0s7ok4uw	3477	21	metastable	metastable	JJ
cord-001835-0s7ok4uw	3477	22	(	(	-LRB-
cord-001835-0s7ok4uw	3477	23	1	1	CD
cord-001835-0s7ok4uw	3477	24	)	)	-RRB-
cord-001835-0s7ok4uw	3477	25	.	.	.
cord-001835-0s7ok4uw	3478	1	Serpins	serpin	NNS
cord-001835-0s7ok4uw	3478	2	use	use	VBP
cord-001835-0s7ok4uw	3478	3	this	this	DT
cord-001835-0s7ok4uw	3478	4	metastability	metastability	NN
cord-001835-0s7ok4uw	3478	5	to	to	TO
cord-001835-0s7ok4uw	3478	6	control	control	VB
cord-001835-0s7ok4uw	3478	7	the	the	DT
cord-001835-0s7ok4uw	3478	8	activity	activity	NN
cord-001835-0s7ok4uw	3478	9	of	of	IN
cord-001835-0s7ok4uw	3478	10	proteases	protease	NNS
cord-001835-0s7ok4uw	3478	11	,	,	,
cord-001835-0s7ok4uw	3478	12	via	via	IN
cord-001835-0s7ok4uw	3478	13	a	a	DT
cord-001835-0s7ok4uw	3478	14	specific	specific	JJ
cord-001835-0s7ok4uw	3478	15	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	3478	16	process	process	NN
cord-001835-0s7ok4uw	3478	17	.	.	.
cord-001835-0s7ok4uw	3479	1	The	the	DT
cord-001835-0s7ok4uw	3479	2	serpin	serpin	NN
cord-001835-0s7ok4uw	3479	3	binds	bind	VBZ
cord-001835-0s7ok4uw	3479	4	to	to	IN
cord-001835-0s7ok4uw	3479	5	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3479	6	target	target	NN
cord-001835-0s7ok4uw	3479	7	protease	protease	NN
cord-001835-0s7ok4uw	3479	8	through	through	IN
cord-001835-0s7ok4uw	3479	9	specific	specific	JJ
cord-001835-0s7ok4uw	3479	10	residues	residue	NNS
cord-001835-0s7ok4uw	3479	11	within	within	IN
cord-001835-0s7ok4uw	3479	12	the	the	DT
cord-001835-0s7ok4uw	3479	13	reactive	reactive	JJ
cord-001835-0s7ok4uw	3479	14	centre	centre	NN
cord-001835-0s7ok4uw	3479	15	loop	loop	NN
cord-001835-0s7ok4uw	3479	16	,	,	,
cord-001835-0s7ok4uw	3479	17	the	the	DT
cord-001835-0s7ok4uw	3479	18	protease	protease	NN
cord-001835-0s7ok4uw	3479	19	cleaves	cleave	VBZ
cord-001835-0s7ok4uw	3479	20	the	the	DT
cord-001835-0s7ok4uw	3479	21	loop	loop	NN
cord-001835-0s7ok4uw	3479	22	and	and	CC
cord-001835-0s7ok4uw	3479	23	results	result	NNS
cord-001835-0s7ok4uw	3479	24	in	in	IN
cord-001835-0s7ok4uw	3479	25	a	a	DT
cord-001835-0s7ok4uw	3479	26	large	large	JJ
cord-001835-0s7ok4uw	3479	27	conformational	conformational	JJ
cord-001835-0s7ok4uw	3479	28	change	change	NN
cord-001835-0s7ok4uw	3479	29	causing	cause	VBG
cord-001835-0s7ok4uw	3479	30	the	the	DT
cord-001835-0s7ok4uw	3479	31	protease	protease	NN
cord-001835-0s7ok4uw	3479	32	to	to	TO
cord-001835-0s7ok4uw	3479	33	become	become	VB
cord-001835-0s7ok4uw	3479	34	distorted	distorted	JJ
cord-001835-0s7ok4uw	3479	35	and	and	CC
cord-001835-0s7ok4uw	3479	36	catalytically	catalytically	RB
cord-001835-0s7ok4uw	3479	37	inactive	inactive	JJ
cord-001835-0s7ok4uw	3479	38	whilst	whilst	IN
cord-001835-0s7ok4uw	3479	39	the	the	DT
cord-001835-0s7ok4uw	3479	40	serpin	serpin	NN
cord-001835-0s7ok4uw	3479	41	becomes	become	VBZ
cord-001835-0s7ok4uw	3479	42	much	much	RB
cord-001835-0s7ok4uw	3479	43	more	more	RBR
cord-001835-0s7ok4uw	3479	44	stable	stable	JJ
cord-001835-0s7ok4uw	3479	45	(	(	-LRB-
cord-001835-0s7ok4uw	3479	46	1	1	CD
cord-001835-0s7ok4uw	3479	47	,	,	,
cord-001835-0s7ok4uw	3479	48	2	2	CD
cord-001835-0s7ok4uw	3479	49	,	,	,
cord-001835-0s7ok4uw	3479	50	3	3	CD
cord-001835-0s7ok4uw	3479	51	)	)	-RRB-
cord-001835-0s7ok4uw	3479	52	.	.	.
cord-001835-0s7ok4uw	3480	1	The	the	DT
cord-001835-0s7ok4uw	3480	2	metastable	metastable	JJ
cord-001835-0s7ok4uw	3480	3	nature	nature	NN
cord-001835-0s7ok4uw	3480	4	of	of	IN
cord-001835-0s7ok4uw	3480	5	AAT	AAT	NNP
cord-001835-0s7ok4uw	3480	6	is	be	VBZ
cord-001835-0s7ok4uw	3480	7	therefore	therefore	RB
cord-001835-0s7ok4uw	3480	8	required	require	VBN
cord-001835-0s7ok4uw	3480	9	to	to	TO
cord-001835-0s7ok4uw	3480	10	facilitate	facilitate	VB
cord-001835-0s7ok4uw	3480	11	the	the	DT
cord-001835-0s7ok4uw	3480	12	rapid	rapid	JJ
cord-001835-0s7ok4uw	3480	13	and	and	CC
cord-001835-0s7ok4uw	3480	14	gross	gross	JJ
cord-001835-0s7ok4uw	3480	15	conformational	conformational	JJ
cord-001835-0s7ok4uw	3480	16	changes	change	NNS
cord-001835-0s7ok4uw	3480	17	required	require	VBN
cord-001835-0s7ok4uw	3480	18	for	for	IN
cord-001835-0s7ok4uw	3480	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3480	20	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	3480	21	function	function	NN
cord-001835-0s7ok4uw	3480	22	(	(	-LRB-
cord-001835-0s7ok4uw	3480	23	2	2	CD
cord-001835-0s7ok4uw	3480	24	,	,	,
cord-001835-0s7ok4uw	3480	25	3	3	CD
cord-001835-0s7ok4uw	3480	26	)	)	-RRB-
cord-001835-0s7ok4uw	3480	27	.	.	.
cord-001835-0s7ok4uw	3481	1	Several	several	JJ
cord-001835-0s7ok4uw	3481	2	disease	disease	NN
cord-001835-0s7ok4uw	3481	3	-	-	HYPH
cord-001835-0s7ok4uw	3481	4	causing	cause	VBG
cord-001835-0s7ok4uw	3481	5	mutants	mutant	NNS
cord-001835-0s7ok4uw	3481	6	of	of	IN
cord-001835-0s7ok4uw	3481	7	AAT	AAT	NNP
cord-001835-0s7ok4uw	3481	8	have	have	VBP
cord-001835-0s7ok4uw	3481	9	been	be	VBN
cord-001835-0s7ok4uw	3481	10	identified	identify	VBN
cord-001835-0s7ok4uw	3481	11	,	,	,
cord-001835-0s7ok4uw	3481	12	the	the	DT
cord-001835-0s7ok4uw	3481	13	most	most	RBS
cord-001835-0s7ok4uw	3481	14	common	common	JJ
cord-001835-0s7ok4uw	3481	15	of	of	IN
cord-001835-0s7ok4uw	3481	16	them	-PRON-	PRP
cord-001835-0s7ok4uw	3481	17	being	be	VBG
cord-001835-0s7ok4uw	3481	18	the	the	DT
cord-001835-0s7ok4uw	3481	19	Z	z	NN
cord-001835-0s7ok4uw	3481	20	-	-	HYPH
cord-001835-0s7ok4uw	3481	21	variant	variant	NN
cord-001835-0s7ok4uw	3481	22	(	(	-LRB-
cord-001835-0s7ok4uw	3481	23	4	4	CD
cord-001835-0s7ok4uw	3481	24	)	)	-RRB-
cord-001835-0s7ok4uw	3481	25	.	.	.
cord-001835-0s7ok4uw	3482	1	The	the	DT
cord-001835-0s7ok4uw	3482	2	Z	z	NN
cord-001835-0s7ok4uw	3482	3	-	-	HYPH
cord-001835-0s7ok4uw	3482	4	variant	variant	NN
cord-001835-0s7ok4uw	3482	5	has	have	VBZ
cord-001835-0s7ok4uw	3482	6	an	an	DT
cord-001835-0s7ok4uw	3482	7	increased	increased	JJ
cord-001835-0s7ok4uw	3482	8	propensity	propensity	NN
cord-001835-0s7ok4uw	3482	9	to	to	TO
cord-001835-0s7ok4uw	3482	10	polymerize	polymerize	VB
cord-001835-0s7ok4uw	3482	11	in	in	IN
cord-001835-0s7ok4uw	3482	12	the	the	DT
cord-001835-0s7ok4uw	3482	13	endoplasmic	endoplasmic	NN
cord-001835-0s7ok4uw	3482	14	reticulum	reticulum	NN
cord-001835-0s7ok4uw	3482	15	of	of	IN
cord-001835-0s7ok4uw	3482	16	hepatocytes	hepatocyte	NNS
cord-001835-0s7ok4uw	3482	17	leading	lead	VBG
cord-001835-0s7ok4uw	3482	18	to	to	IN
cord-001835-0s7ok4uw	3482	19	cell	cell	NN
cord-001835-0s7ok4uw	3482	20	death	death	NN
cord-001835-0s7ok4uw	3482	21	and	and	CC
cord-001835-0s7ok4uw	3482	22	liver	liver	NN
cord-001835-0s7ok4uw	3482	23	damage	damage	NN
cord-001835-0s7ok4uw	3482	24	(	(	-LRB-
cord-001835-0s7ok4uw	3482	25	4	4	CD
cord-001835-0s7ok4uw	3482	26	)	)	-RRB-
cord-001835-0s7ok4uw	3482	27	.	.	.
cord-001835-0s7ok4uw	3483	1	During	during	IN
cord-001835-0s7ok4uw	3483	2	the	the	DT
cord-001835-0s7ok4uw	3483	3	past	past	JJ
cord-001835-0s7ok4uw	3483	4	fifteen	fifteen	CD
cord-001835-0s7ok4uw	3483	5	years	year	NNS
cord-001835-0s7ok4uw	3483	6	,	,	,
cord-001835-0s7ok4uw	3483	7	many	many	JJ
cord-001835-0s7ok4uw	3483	8	groups	group	NNS
cord-001835-0s7ok4uw	3483	9	have	have	VBP
cord-001835-0s7ok4uw	3483	10	unsuccessfully	unsuccessfully	RB
cord-001835-0s7ok4uw	3483	11	screened	screen	VBN
cord-001835-0s7ok4uw	3483	12	a	a	DT
cord-001835-0s7ok4uw	3483	13	number	number	NN
cord-001835-0s7ok4uw	3483	14	of	of	IN
cord-001835-0s7ok4uw	3483	15	serpins	serpin	NNS
cord-001835-0s7ok4uw	3483	16	and	and	CC
cord-001835-0s7ok4uw	3483	17	a	a	DT
cord-001835-0s7ok4uw	3483	18	vast	vast	JJ
cord-001835-0s7ok4uw	3483	19	range	range	NN
cord-001835-0s7ok4uw	3483	20	of	of	IN
cord-001835-0s7ok4uw	3483	21	solution	solution	NN
cord-001835-0s7ok4uw	3483	22	conditions	condition	NNS
cord-001835-0s7ok4uw	3483	23	to	to	TO
cord-001835-0s7ok4uw	3483	24	identify	identify	VB
cord-001835-0s7ok4uw	3483	25	a	a	DT
cord-001835-0s7ok4uw	3483	26	combination	combination	NN
cord-001835-0s7ok4uw	3483	27	of	of	IN
cord-001835-0s7ok4uw	3483	28	serpin	serpin	NN
cord-001835-0s7ok4uw	3483	29	and	and	CC
cord-001835-0s7ok4uw	3483	30	conditions	condition	NNS
cord-001835-0s7ok4uw	3483	31	that	that	WDT
cord-001835-0s7ok4uw	3483	32	will	will	MD
cord-001835-0s7ok4uw	3483	33	enable	enable	VB
cord-001835-0s7ok4uw	3483	34	the	the	DT
cord-001835-0s7ok4uw	3483	35	folding	folding	NN
cord-001835-0s7ok4uw	3483	36	reaction	reaction	NN
cord-001835-0s7ok4uw	3483	37	of	of	IN
cord-001835-0s7ok4uw	3483	38	a	a	DT
cord-001835-0s7ok4uw	3483	39	serpin	serpin	NN
cord-001835-0s7ok4uw	3483	40	to	to	TO
cord-001835-0s7ok4uw	3483	41	be	be	VB
cord-001835-0s7ok4uw	3483	42	characterized	characterize	VBN
cord-001835-0s7ok4uw	3483	43	.	.	.
cord-001835-0s7ok4uw	3484	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3484	2	have	have	VBP
cord-001835-0s7ok4uw	3484	3	now	now	RB
cord-001835-0s7ok4uw	3484	4	taken	take	VBN
cord-001835-0s7ok4uw	3484	5	an	an	DT
cord-001835-0s7ok4uw	3484	6	alternative	alternative	JJ
cord-001835-0s7ok4uw	3484	7	approach	approach	NN
cord-001835-0s7ok4uw	3484	8	and	and	CC
cord-001835-0s7ok4uw	3484	9	designed	design	VBD
cord-001835-0s7ok4uw	3484	10	a	a	DT
cord-001835-0s7ok4uw	3484	11	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3484	12	"	"	``
cord-001835-0s7ok4uw	3484	13	model	model	NN
cord-001835-0s7ok4uw	3484	14	"	"	''
cord-001835-0s7ok4uw	3484	15	serpin	serpin	NN
cord-001835-0s7ok4uw	3484	16	that	that	WDT
cord-001835-0s7ok4uw	3484	17	folds	fold	VBZ
cord-001835-0s7ok4uw	3484	18	reversibly	reversibly	RB
cord-001835-0s7ok4uw	3484	19	to	to	IN
cord-001835-0s7ok4uw	3484	20	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3484	21	native	native	JJ
cord-001835-0s7ok4uw	3484	22	state	state	NN
cord-001835-0s7ok4uw	3484	23	.	.	.
cord-001835-0s7ok4uw	3485	1	In	in	IN
cord-001835-0s7ok4uw	3485	2	order	order	NN
cord-001835-0s7ok4uw	3485	3	to	to	TO
cord-001835-0s7ok4uw	3485	4	do	do	VB
cord-001835-0s7ok4uw	3485	5	this	this	DT
cord-001835-0s7ok4uw	3485	6	,	,	,
cord-001835-0s7ok4uw	3485	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	3485	8	used	use	VBD
cord-001835-0s7ok4uw	3485	9	a	a	DT
cord-001835-0s7ok4uw	3485	10	consensus	consensus	NN
cord-001835-0s7ok4uw	3485	11	design	design	NN
cord-001835-0s7ok4uw	3485	12	approach	approach	NN
cord-001835-0s7ok4uw	3485	13	,	,	,
cord-001835-0s7ok4uw	3485	14	analysing	analyse	VBG
cord-001835-0s7ok4uw	3485	15	a	a	DT
cord-001835-0s7ok4uw	3485	16	sequence	sequence	NN
cord-001835-0s7ok4uw	3485	17	alignment	alignment	NN
cord-001835-0s7ok4uw	3485	18	of	of	IN
cord-001835-0s7ok4uw	3485	19	212	212	CD
cord-001835-0s7ok4uw	3485	20	serpin	serpin	NN
cord-001835-0s7ok4uw	3485	21	sequences	sequence	NNS
cord-001835-0s7ok4uw	3485	22	and	and	CC
cord-001835-0s7ok4uw	3485	23	determining	determine	VBG
cord-001835-0s7ok4uw	3485	24	the	the	DT
cord-001835-0s7ok4uw	3485	25	prevalent	prevalent	JJ
cord-001835-0s7ok4uw	3485	26	amino	amino	NN
cord-001835-0s7ok4uw	3485	27	acid	acid	NN
cord-001835-0s7ok4uw	3485	28	residue	residue	NN
cord-001835-0s7ok4uw	3485	29	at	at	IN
cord-001835-0s7ok4uw	3485	30	each	each	DT
cord-001835-0s7ok4uw	3485	31	position	position	NN
cord-001835-0s7ok4uw	3485	32	,	,	,
cord-001835-0s7ok4uw	3485	33	we	-PRON-	PRP
cord-001835-0s7ok4uw	3485	34	termed	term	VBD
cord-001835-0s7ok4uw	3485	35	this	this	DT
cord-001835-0s7ok4uw	3485	36	serpin	serpin	NN
cord-001835-0s7ok4uw	3485	37	conserpin	conserpin	NNP
cord-001835-0s7ok4uw	3485	38	(	(	-LRB-
cord-001835-0s7ok4uw	3485	39	consensus	consensus	NN
cord-001835-0s7ok4uw	3485	40	serpin	serpin	NNP
cord-001835-0s7ok4uw	3485	41	)	)	-RRB-
cord-001835-0s7ok4uw	3485	42	.	.	.
cord-001835-0s7ok4uw	3486	1	Here	here	RB
cord-001835-0s7ok4uw	3486	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3486	3	present	present	VBP
cord-001835-0s7ok4uw	3486	4	the	the	DT
cord-001835-0s7ok4uw	3486	5	structural	structural	JJ
cord-001835-0s7ok4uw	3486	6	,	,	,
cord-001835-0s7ok4uw	3486	7	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	3486	8	and	and	CC
cord-001835-0s7ok4uw	3486	9	functional	functional	JJ
cord-001835-0s7ok4uw	3486	10	characterisation	characterisation	NN
cord-001835-0s7ok4uw	3486	11	of	of	IN
cord-001835-0s7ok4uw	3486	12	conserpin	conserpin	NNP
cord-001835-0s7ok4uw	3486	13	.	.	.
cord-001835-0s7ok4uw	3487	1	Combined	combine	VBN
cord-001835-0s7ok4uw	3487	2	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	3487	3	and	and	CC
cord-001835-0s7ok4uw	3487	4	folding	folding	NN
cord-001835-0s7ok4uw	3487	5	studies	study	NNS
cord-001835-0s7ok4uw	3487	6	reveal	reveal	VBP
cord-001835-0s7ok4uw	3487	7	the	the	DT
cord-001835-0s7ok4uw	3487	8	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	3487	9	of	of	IN
cord-001835-0s7ok4uw	3487	10	conserpin	conserpin	NNP
cord-001835-0s7ok4uw	3487	11	that	that	WDT
cord-001835-0s7ok4uw	3487	12	likely	likely	RB
cord-001835-0s7ok4uw	3487	13	dictate	dictate	VB
cord-001835-0s7ok4uw	3487	14	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3487	15	unique	unique	JJ
cord-001835-0s7ok4uw	3487	16	stability	stability	NN
cord-001835-0s7ok4uw	3487	17	and	and	CC
cord-001835-0s7ok4uw	3487	18	folding	folding	NN
cord-001835-0s7ok4uw	3487	19	behaviour	behaviour	NN
cord-001835-0s7ok4uw	3487	20	,	,	,
cord-001835-0s7ok4uw	3487	21	whilst	whilst	IN
cord-001835-0s7ok4uw	3487	22	retaining	retain	VBG
cord-001835-0s7ok4uw	3487	23	activity	activity	NN
cord-001835-0s7ok4uw	3487	24	as	as	IN
cord-001835-0s7ok4uw	3487	25	a	a	DT
cord-001835-0s7ok4uw	3487	26	serine	serine	NN
cord-001835-0s7ok4uw	3487	27	protease	protease	NN
cord-001835-0s7ok4uw	3487	28	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	3487	29	.	.	.
cord-001835-0s7ok4uw	3488	1	The	the	DT
cord-001835-0s7ok4uw	3488	2	development	development	NN
cord-001835-0s7ok4uw	3488	3	of	of	IN
cord-001835-0s7ok4uw	3488	4	enhanced	enhanced	JJ
cord-001835-0s7ok4uw	3488	5	protein	protein	NN
cord-001835-0s7ok4uw	3488	6	binding	bind	VBG
cord-001835-0s7ok4uw	3488	7	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3488	8	is	be	VBZ
cord-001835-0s7ok4uw	3488	9	a	a	DT
cord-001835-0s7ok4uw	3488	10	key	key	NN
cord-001835-0s7ok4uw	3488	11	for	for	IN
cord-001835-0s7ok4uw	3488	12	engineering	engineer	VBG
cord-001835-0s7ok4uw	3488	13	protein	protein	NN
cord-001835-0s7ok4uw	3488	14	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	3488	15	and	and	CC
cord-001835-0s7ok4uw	3488	16	biosensors	biosensor	NNS
cord-001835-0s7ok4uw	3488	17	with	with	IN
cord-001835-0s7ok4uw	3488	18	advanced	advanced	JJ
cord-001835-0s7ok4uw	3488	19	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	3488	20	.	.	.
cord-001835-0s7ok4uw	3489	1	Utilizing	utilize	VBG
cord-001835-0s7ok4uw	3489	2	the	the	DT
cord-001835-0s7ok4uw	3489	3	structural	structural	JJ
cord-001835-0s7ok4uw	3489	4	variability	variability	NN
cord-001835-0s7ok4uw	3489	5	and	and	CC
cord-001835-0s7ok4uw	3489	6	designability	designability	NN
cord-001835-0s7ok4uw	3489	7	of	of	IN
cord-001835-0s7ok4uw	3489	8	repeat	repeat	NN
cord-001835-0s7ok4uw	3489	9	proteins	protein	NNS
cord-001835-0s7ok4uw	3489	10	offers	offer	VBZ
cord-001835-0s7ok4uw	3489	11	a	a	DT
cord-001835-0s7ok4uw	3489	12	means	means	NN
cord-001835-0s7ok4uw	3489	13	for	for	IN
cord-001835-0s7ok4uw	3489	14	designing	design	VBG
cord-001835-0s7ok4uw	3489	15	protein	protein	NN
cord-001835-0s7ok4uw	3489	16	binders	binder	NNS
cord-001835-0s7ok4uw	3489	17	where	where	WRB
cord-001835-0s7ok4uw	3489	18	the	the	DT
cord-001835-0s7ok4uw	3489	19	overall	overall	JJ
cord-001835-0s7ok4uw	3489	20	shape	shape	NN
cord-001835-0s7ok4uw	3489	21	is	be	VBZ
cord-001835-0s7ok4uw	3489	22	customized	customize	VBN
cord-001835-0s7ok4uw	3489	23	to	to	TO
cord-001835-0s7ok4uw	3489	24	optimally	optimally	RB
cord-001835-0s7ok4uw	3489	25	match	match	VB
cord-001835-0s7ok4uw	3489	26	a	a	DT
cord-001835-0s7ok4uw	3489	27	target	target	NN
cord-001835-0s7ok4uw	3489	28	molecule	molecule	NN
cord-001835-0s7ok4uw	3489	29	.	.	.
cord-001835-0s7ok4uw	3490	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3490	2	developed	develop	VBD
cord-001835-0s7ok4uw	3490	3	a	a	DT
cord-001835-0s7ok4uw	3490	4	computational	computational	JJ
cord-001835-0s7ok4uw	3490	5	protocol	protocol	NN
cord-001835-0s7ok4uw	3490	6	for	for	IN
cord-001835-0s7ok4uw	3490	7	the	the	DT
cord-001835-0s7ok4uw	3490	8	design	design	NN
cord-001835-0s7ok4uw	3490	9	of	of	IN
cord-001835-0s7ok4uw	3490	10	repeat	repeat	NN
cord-001835-0s7ok4uw	3490	11	proteins	protein	NNS
cord-001835-0s7ok4uw	3490	12	with	with	IN
cord-001835-0s7ok4uw	3490	13	a	a	DT
cord-001835-0s7ok4uw	3490	14	predefined	predefined	JJ
cord-001835-0s7ok4uw	3490	15	geometry	geometry	NN
cord-001835-0s7ok4uw	3490	16	.	.	.
cord-001835-0s7ok4uw	3491	1	By	by	IN
cord-001835-0s7ok4uw	3491	2	combining	combine	VBG
cord-001835-0s7ok4uw	3491	3	sequence	sequence	NN
cord-001835-0s7ok4uw	3491	4	optimization	optimization	NN
cord-001835-0s7ok4uw	3491	5	of	of	IN
cord-001835-0s7ok4uw	3491	6	existing	exist	VBG
cord-001835-0s7ok4uw	3491	7	repeats	repeat	NNS
cord-001835-0s7ok4uw	3491	8	and	and	CC
cord-001835-0s7ok4uw	3491	9	de	de	FW
cord-001835-0s7ok4uw	3491	10	novo	novo	NNP
cord-001835-0s7ok4uw	3491	11	design	design	NN
cord-001835-0s7ok4uw	3491	12	of	of	IN
cord-001835-0s7ok4uw	3491	13	capping	cap	VBG
cord-001835-0s7ok4uw	3491	14	structures	structure	NNS
cord-001835-0s7ok4uw	3491	15	,	,	,
cord-001835-0s7ok4uw	3491	16	we	-PRON-	PRP
cord-001835-0s7ok4uw	3491	17	designed	design	VBD
cord-001835-0s7ok4uw	3491	18	leucine	leucine	NN
cord-001835-0s7ok4uw	3491	19	-	-	HYPH
cord-001835-0s7ok4uw	3491	20	rich	rich	JJ
cord-001835-0s7ok4uw	3491	21	repeat	repeat	NN
cord-001835-0s7ok4uw	3491	22	(	(	-LRB-
cord-001835-0s7ok4uw	3491	23	LRR	LRR	NNP
cord-001835-0s7ok4uw	3491	24	)	)	-RRB-
cord-001835-0s7ok4uw	3491	25	proteins	protein	NNS
cord-001835-0s7ok4uw	3491	26	where	where	WRB
cord-001835-0s7ok4uw	3491	27	the	the	DT
cord-001835-0s7ok4uw	3491	28	building	building	NN
cord-001835-0s7ok4uw	3491	29	blocks	block	NNS
cord-001835-0s7ok4uw	3491	30	assemble	assemble	VBP
cord-001835-0s7ok4uw	3491	31	into	into	IN
cord-001835-0s7ok4uw	3491	32	a	a	DT
cord-001835-0s7ok4uw	3491	33	novel	novel	JJ
cord-001835-0s7ok4uw	3491	34	structure	structure	NN
cord-001835-0s7ok4uw	3491	35	.	.	.
cord-001835-0s7ok4uw	3492	1	The	the	DT
cord-001835-0s7ok4uw	3492	2	suggested	suggest	VBN
cord-001835-0s7ok4uw	3492	3	design	design	NN
cord-001835-0s7ok4uw	3492	4	procedure	procedure	NN
cord-001835-0s7ok4uw	3492	5	was	be	VBD
cord-001835-0s7ok4uw	3492	6	validated	validate	VBN
cord-001835-0s7ok4uw	3492	7	by	by	IN
cord-001835-0s7ok4uw	3492	8	engineering	engineer	VBG
cord-001835-0s7ok4uw	3492	9	an	an	DT
cord-001835-0s7ok4uw	3492	10	artificial	artificial	JJ
cord-001835-0s7ok4uw	3492	11	donut	donut	NN
cord-001835-0s7ok4uw	3492	12	-	-	HYPH
cord-001835-0s7ok4uw	3492	13	like	like	JJ
cord-001835-0s7ok4uw	3492	14	ring	ring	NN
cord-001835-0s7ok4uw	3492	15	structure	structure	NN
cord-001835-0s7ok4uw	3492	16	,	,	,
cord-001835-0s7ok4uw	3492	17	which	which	WDT
cord-001835-0s7ok4uw	3492	18	is	be	VBZ
cord-001835-0s7ok4uw	3492	19	constructed	construct	VBN
cord-001835-0s7ok4uw	3492	20	from	from	IN
cord-001835-0s7ok4uw	3492	21	ten	ten	CD
cord-001835-0s7ok4uw	3492	22	self	self	NN
cord-001835-0s7ok4uw	3492	23	-	-	HYPH
cord-001835-0s7ok4uw	3492	24	compatible	compatible	JJ
cord-001835-0s7ok4uw	3492	25	repeats	repeat	NNS
cord-001835-0s7ok4uw	3492	26	.	.	.
cord-001835-0s7ok4uw	3493	1	Characterization	characterization	NN
cord-001835-0s7ok4uw	3493	2	of	of	IN
cord-001835-0s7ok4uw	3493	3	several	several	JJ
cord-001835-0s7ok4uw	3493	4	designed	design	VBN
cord-001835-0s7ok4uw	3493	5	constructs	construct	NNS
cord-001835-0s7ok4uw	3493	6	further	further	RB
cord-001835-0s7ok4uw	3493	7	suggests	suggest	VBZ
cord-001835-0s7ok4uw	3493	8	that	that	IN
cord-001835-0s7ok4uw	3493	9	buried	bury	VBN
cord-001835-0s7ok4uw	3493	10	cysteines	cysteine	NNS
cord-001835-0s7ok4uw	3493	11	play	play	VBP
cord-001835-0s7ok4uw	3493	12	a	a	DT
cord-001835-0s7ok4uw	3493	13	central	central	JJ
cord-001835-0s7ok4uw	3493	14	role	role	NN
cord-001835-0s7ok4uw	3493	15	for	for	IN
cord-001835-0s7ok4uw	3493	16	stability	stability	NN
cord-001835-0s7ok4uw	3493	17	and	and	CC
cord-001835-0s7ok4uw	3493	18	folding	fold	VBG
cord-001835-0s7ok4uw	3493	19	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	3493	20	in	in	IN
cord-001835-0s7ok4uw	3493	21	certain	certain	JJ
cord-001835-0s7ok4uw	3493	22	LRR	LRR	NNP
cord-001835-0s7ok4uw	3493	23	proteins	protein	NNS
cord-001835-0s7ok4uw	3493	24	.	.	.
cord-001835-0s7ok4uw	3494	1	This	this	DT
cord-001835-0s7ok4uw	3494	2	effect	effect	NN
cord-001835-0s7ok4uw	3494	3	could	could	MD
cord-001835-0s7ok4uw	3494	4	provide	provide	VB
cord-001835-0s7ok4uw	3494	5	a	a	DT
cord-001835-0s7ok4uw	3494	6	means	means	NN
cord-001835-0s7ok4uw	3494	7	for	for	IN
cord-001835-0s7ok4uw	3494	8	selectively	selectively	RB
cord-001835-0s7ok4uw	3494	9	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	3494	10	or	or	CC
cord-001835-0s7ok4uw	3494	11	destabilizing	destabilizing	JJ
cord-001835-0s7ok4uw	3494	12	specific	specific	JJ
cord-001835-0s7ok4uw	3494	13	parts	part	NNS
cord-001835-0s7ok4uw	3494	14	of	of	IN
cord-001835-0s7ok4uw	3494	15	an	an	DT
cord-001835-0s7ok4uw	3494	16	LRR	LRR	NNP
cord-001835-0s7ok4uw	3494	17	-	-	HYPH
cord-001835-0s7ok4uw	3494	18	based	base	VBN
cord-001835-0s7ok4uw	3494	19	protein	protein	NN
cord-001835-0s7ok4uw	3494	20	binder	binder	NN
cord-001835-0s7ok4uw	3494	21	.	.	.
cord-001835-0s7ok4uw	3495	1	The	the	DT
cord-001835-0s7ok4uw	3495	2	computational	computational	JJ
cord-001835-0s7ok4uw	3495	3	procedure	procedure	NN
cord-001835-0s7ok4uw	3495	4	may	may	MD
cord-001835-0s7ok4uw	3495	5	now	now	RB
cord-001835-0s7ok4uw	3495	6	be	be	VB
cord-001835-0s7ok4uw	3495	7	employed	employ	VBN
cord-001835-0s7ok4uw	3495	8	to	to	TO
cord-001835-0s7ok4uw	3495	9	develop	develop	VB
cord-001835-0s7ok4uw	3495	10	repeat	repeat	NN
cord-001835-0s7ok4uw	3495	11	proteins	protein	NNS
cord-001835-0s7ok4uw	3495	12	with	with	IN
cord-001835-0s7ok4uw	3495	13	various	various	JJ
cord-001835-0s7ok4uw	3495	14	geometrical	geometrical	JJ
cord-001835-0s7ok4uw	3495	15	shapes	shape	NNS
cord-001835-0s7ok4uw	3495	16	for	for	IN
cord-001835-0s7ok4uw	3495	17	applications	application	NNS
cord-001835-0s7ok4uw	3495	18	where	where	WRB
cord-001835-0s7ok4uw	3495	19	greater	great	JJR
cord-001835-0s7ok4uw	3495	20	control	control	NN
cord-001835-0s7ok4uw	3495	21	of	of	IN
cord-001835-0s7ok4uw	3495	22	the	the	DT
cord-001835-0s7ok4uw	3495	23	interface	interface	NN
cord-001835-0s7ok4uw	3495	24	geometry	geometry	NN
cord-001835-0s7ok4uw	3495	25	is	be	VBZ
cord-001835-0s7ok4uw	3495	26	desired	desire	VBN
cord-001835-0s7ok4uw	3495	27	.	.	.
cord-001835-0s7ok4uw	3496	1	Engineering	engineering	NN
cord-001835-0s7ok4uw	3496	2	APOBEC3	apobec3	DT
cord-001835-0s7ok4uw	3496	3	G	g	NN
cord-001835-0s7ok4uw	3496	4	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3496	5	for	for	IN
cord-001835-0s7ok4uw	3496	6	altered	alter	VBN
cord-001835-0s7ok4uw	3496	7	specificity	specificity	NN
cord-001835-0s7ok4uw	3496	8	and	and	CC
cord-001835-0s7ok4uw	3496	9	processivity	processivity	NN
cord-001835-0s7ok4uw	3496	10	Louis	Louis	NNP
cord-001835-0s7ok4uw	3496	11	Scott	Scott	NNP
cord-001835-0s7ok4uw	3496	12	1	1	CD
cord-001835-0s7ok4uw	3496	13	,	,	,
cord-001835-0s7ok4uw	3496	14	Muhammad	Muhammad	NNP
cord-001835-0s7ok4uw	3496	15	Razif	Razif	NNP
cord-001835-0s7ok4uw	3496	16	1	1	CD
cord-001835-0s7ok4uw	3496	17	,	,	,
cord-001835-0s7ok4uw	3496	18	Aleksandra	Aleksandra	NNP
cord-001835-0s7ok4uw	3496	19	Filipovska	Filipovska	NNP
cord-001835-0s7ok4uw	3496	20	1,2	1,2	CD
cord-001835-0s7ok4uw	3496	21	,	,	,
cord-001835-0s7ok4uw	3496	22	Oliver	Oliver	NNP
cord-001835-0s7ok4uw	3496	23	Rackham	Rackham	NNP
cord-001835-0s7ok4uw	3496	24	1,2	1,2	CD
cord-001835-0s7ok4uw	3496	25	1	1	CD
cord-001835-0s7ok4uw	3496	26	Harry	Harry	NNP
cord-001835-0s7ok4uw	3496	27	Perkins	Perkins	NNP
cord-001835-0s7ok4uw	3496	28	institute	institute	NN
cord-001835-0s7ok4uw	3496	29	of	of	IN
cord-001835-0s7ok4uw	3496	30	Medical	Medical	NNP
cord-001835-0s7ok4uw	3496	31	Research	Research	NNP
cord-001835-0s7ok4uw	3496	32	,	,	,
cord-001835-0s7ok4uw	3496	33	2	2	CD
cord-001835-0s7ok4uw	3496	34	School	School	NNP
cord-001835-0s7ok4uw	3496	35	of	of	IN
cord-001835-0s7ok4uw	3496	36	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	3496	37	and	and	CC
cord-001835-0s7ok4uw	3496	38	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	3496	39	,	,	,
cord-001835-0s7ok4uw	3496	40	The	the	DT
cord-001835-0s7ok4uw	3496	41	University	University	NNP
cord-001835-0s7ok4uw	3496	42	of	of	IN
cord-001835-0s7ok4uw	3496	43	Western	Western	NNP
cord-001835-0s7ok4uw	3496	44	Australia	Australia	NNP
cord-001835-0s7ok4uw	3496	45	APOBEC3	apobec3	NN
cord-001835-0s7ok4uw	3496	46	G	g	NN
cord-001835-0s7ok4uw	3496	47	(	(	-LRB-
cord-001835-0s7ok4uw	3496	48	A3	A3	NNP
cord-001835-0s7ok4uw	3496	49	G	G	NNP
cord-001835-0s7ok4uw	3496	50	)	)	-RRB-
cord-001835-0s7ok4uw	3496	51	is	be	VBZ
cord-001835-0s7ok4uw	3496	52	a	a	DT
cord-001835-0s7ok4uw	3496	53	host	host	NN
cord-001835-0s7ok4uw	3496	54	-	-	HYPH
cord-001835-0s7ok4uw	3496	55	encoded	encode	VBN
cord-001835-0s7ok4uw	3496	56	protein	protein	NN
cord-001835-0s7ok4uw	3496	57	involved	involve	VBN
cord-001835-0s7ok4uw	3496	58	in	in	IN
cord-001835-0s7ok4uw	3496	59	the	the	DT
cord-001835-0s7ok4uw	3496	60	defense	defense	NN
cord-001835-0s7ok4uw	3496	61	against	against	IN
cord-001835-0s7ok4uw	3496	62	HIV-1	HIV-1	NNP
cord-001835-0s7ok4uw	3496	63	and	and	CC
cord-001835-0s7ok4uw	3496	64	other	other	JJ
cord-001835-0s7ok4uw	3496	65	retroviral	retroviral	JJ
cord-001835-0s7ok4uw	3496	66	infections	infection	NNS
cord-001835-0s7ok4uw	3496	67	.	.	.
cord-001835-0s7ok4uw	3497	1	A3	A3	NNP
cord-001835-0s7ok4uw	3497	2	G	G	NNP
cord-001835-0s7ok4uw	3497	3	is	be	VBZ
cord-001835-0s7ok4uw	3497	4	a	a	DT
cord-001835-0s7ok4uw	3497	5	cytidine	cytidine	NN
cord-001835-0s7ok4uw	3497	6	deaminase	deaminase	JJ
cord-001835-0s7ok4uw	3497	7	with	with	IN
cord-001835-0s7ok4uw	3497	8	a	a	DT
cord-001835-0s7ok4uw	3497	9	3	3	CD
cord-001835-0s7ok4uw	3497	10	'	'	''
cord-001835-0s7ok4uw	3497	11	to	to	IN
cord-001835-0s7ok4uw	3497	12	5	5	CD
cord-001835-0s7ok4uw	3497	13	'	'	POS
cord-001835-0s7ok4uw	3497	14	processive	processive	JJ
cord-001835-0s7ok4uw	3497	15	nature	nature	NN
cord-001835-0s7ok4uw	3497	16	,	,	,
cord-001835-0s7ok4uw	3497	17	causing	cause	VBG
cord-001835-0s7ok4uw	3497	18	targeted	target	VBN
cord-001835-0s7ok4uw	3497	19	C	c	NN
cord-001835-0s7ok4uw	3497	20	to	to	IN
cord-001835-0s7ok4uw	3497	21	T	t	NN
cord-001835-0s7ok4uw	3497	22	mutations	mutation	NNS
cord-001835-0s7ok4uw	3497	23	along	along	IN
cord-001835-0s7ok4uw	3497	24	a	a	DT
cord-001835-0s7ok4uw	3497	25	DNA	dna	NN
cord-001835-0s7ok4uw	3497	26	strand	strand	NN
cord-001835-0s7ok4uw	3497	27	.	.	.
cord-001835-0s7ok4uw	3498	1	The	the	DT
cord-001835-0s7ok4uw	3498	2	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3498	3	and	and	CC
cord-001835-0s7ok4uw	3498	4	processive	processive	JJ
cord-001835-0s7ok4uw	3498	5	activity	activity	NN
cord-001835-0s7ok4uw	3498	6	of	of	IN
cord-001835-0s7ok4uw	3498	7	A3	A3	NNP
cord-001835-0s7ok4uw	3498	8	G	G	NNP
cord-001835-0s7ok4uw	3498	9	leads	lead	VBZ
cord-001835-0s7ok4uw	3498	10	to	to	IN
cord-001835-0s7ok4uw	3498	11	the	the	DT
cord-001835-0s7ok4uw	3498	12	hypermutation	hypermutation	NN
cord-001835-0s7ok4uw	3498	13	of	of	IN
cord-001835-0s7ok4uw	3498	14	nascent	nascent	JJ
cord-001835-0s7ok4uw	3498	15	retroviral	retroviral	NN
cord-001835-0s7ok4uw	3498	16	cDNA	cdna	NN
cord-001835-0s7ok4uw	3498	17	,	,	,
cord-001835-0s7ok4uw	3498	18	resulting	result	VBG
cord-001835-0s7ok4uw	3498	19	in	in	IN
cord-001835-0s7ok4uw	3498	20	premature	premature	JJ
cord-001835-0s7ok4uw	3498	21	termination	termination	NN
cord-001835-0s7ok4uw	3498	22	codons	codon	NNS
cord-001835-0s7ok4uw	3498	23	and	and	CC
cord-001835-0s7ok4uw	3498	24	dysfunctional	dysfunctional	JJ
cord-001835-0s7ok4uw	3498	25	proteins	protein	NNS
cord-001835-0s7ok4uw	3498	26	.	.	.
cord-001835-0s7ok4uw	3499	1	Ultimately	ultimately	RB
cord-001835-0s7ok4uw	3499	2	,	,	,
cord-001835-0s7ok4uw	3499	3	the	the	DT
cord-001835-0s7ok4uw	3499	4	action	action	NN
cord-001835-0s7ok4uw	3499	5	of	of	IN
cord-001835-0s7ok4uw	3499	6	A3	A3	NNP
cord-001835-0s7ok4uw	3499	7	G	G	NNP
cord-001835-0s7ok4uw	3499	8	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	3499	9	viral	viral	JJ
cord-001835-0s7ok4uw	3499	10	replication	replication	NN
cord-001835-0s7ok4uw	3499	11	.	.	.
cord-001835-0s7ok4uw	3500	1	The	the	DT
cord-001835-0s7ok4uw	3500	2	ability	ability	NN
cord-001835-0s7ok4uw	3500	3	of	of	IN
cord-001835-0s7ok4uw	3500	4	A3	A3	NNP
cord-001835-0s7ok4uw	3500	5	G	G	NNP
cord-001835-0s7ok4uw	3500	6	to	to	TO
cord-001835-0s7ok4uw	3500	7	jump	jump	VB
cord-001835-0s7ok4uw	3500	8	and	and	CC
cord-001835-0s7ok4uw	3500	9	slide	slide	VB
cord-001835-0s7ok4uw	3500	10	along	along	IN
cord-001835-0s7ok4uw	3500	11	a	a	DT
cord-001835-0s7ok4uw	3500	12	DNA	dna	NN
cord-001835-0s7ok4uw	3500	13	strand	strand	NN
cord-001835-0s7ok4uw	3500	14	,	,	,
cord-001835-0s7ok4uw	3500	15	deaminating	deaminate	VBG
cord-001835-0s7ok4uw	3500	16	at	at	IN
cord-001835-0s7ok4uw	3500	17	targeted	target	VBN
cord-001835-0s7ok4uw	3500	18	sequences	sequence	NNS
cord-001835-0s7ok4uw	3500	19	,	,	,
cord-001835-0s7ok4uw	3500	20	makes	make	VBZ
cord-001835-0s7ok4uw	3500	21	it	-PRON-	PRP
cord-001835-0s7ok4uw	3500	22	an	an	DT
cord-001835-0s7ok4uw	3500	23	interesting	interesting	JJ
cord-001835-0s7ok4uw	3500	24	candidate	candidate	NN
cord-001835-0s7ok4uw	3500	25	for	for	IN
cord-001835-0s7ok4uw	3500	26	protein	protein	NN
cord-001835-0s7ok4uw	3500	27	engineering	engineering	NN
cord-001835-0s7ok4uw	3500	28	.	.	.
cord-001835-0s7ok4uw	3501	1	Engineered	engineer	VBN
cord-001835-0s7ok4uw	3501	2	A3	A3	NNP
cord-001835-0s7ok4uw	3501	3	G	g	NN
cord-001835-0s7ok4uw	3501	4	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3501	5	for	for	IN
cord-001835-0s7ok4uw	3501	6	increased	increase	VBN
cord-001835-0s7ok4uw	3501	7	activity	activity	NN
cord-001835-0s7ok4uw	3501	8	,	,	,
cord-001835-0s7ok4uw	3501	9	altered	alter	VBN
cord-001835-0s7ok4uw	3501	10	specificity	specificity	NN
cord-001835-0s7ok4uw	3501	11	,	,	,
cord-001835-0s7ok4uw	3501	12	and	and	CC
cord-001835-0s7ok4uw	3501	13	altered	altered	JJ
cord-001835-0s7ok4uw	3501	14	processivity	processivity	NN
cord-001835-0s7ok4uw	3501	15	are	be	VBP
cord-001835-0s7ok4uw	3501	16	attractive	attractive	JJ
cord-001835-0s7ok4uw	3501	17	options	option	NNS
cord-001835-0s7ok4uw	3501	18	for	for	IN
cord-001835-0s7ok4uw	3501	19	expanding	expand	VBG
cord-001835-0s7ok4uw	3501	20	the	the	DT
cord-001835-0s7ok4uw	3501	21	DNA	dna	NN
cord-001835-0s7ok4uw	3501	22	modifying	modify	VBG
cord-001835-0s7ok4uw	3501	23	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3501	24	toolbox	toolbox	NN
cord-001835-0s7ok4uw	3501	25	.	.	.
cord-001835-0s7ok4uw	3502	1	Mutation	mutation	NN
cord-001835-0s7ok4uw	3502	2	of	of	IN
cord-001835-0s7ok4uw	3502	3	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3502	4	residues	residue	NNS
cord-001835-0s7ok4uw	3502	5	,	,	,
cord-001835-0s7ok4uw	3502	6	residues	residue	NNS
cord-001835-0s7ok4uw	3502	7	thought	think	VBD
cord-001835-0s7ok4uw	3502	8	to	to	TO
cord-001835-0s7ok4uw	3502	9	affect	affect	VB
cord-001835-0s7ok4uw	3502	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3502	11	processive	processive	JJ
cord-001835-0s7ok4uw	3502	12	nature	nature	NN
cord-001835-0s7ok4uw	3502	13	and	and	CC
cord-001835-0s7ok4uw	3502	14	those	those	DT
cord-001835-0s7ok4uw	3502	15	thought	think	VBN
cord-001835-0s7ok4uw	3502	16	to	to	TO
cord-001835-0s7ok4uw	3502	17	be	be	VB
cord-001835-0s7ok4uw	3502	18	involved	involve	VBN
cord-001835-0s7ok4uw	3502	19	in	in	IN
cord-001835-0s7ok4uw	3502	20	target	target	NN
cord-001835-0s7ok4uw	3502	21	recognition	recognition	NN
cord-001835-0s7ok4uw	3502	22	,	,	,
cord-001835-0s7ok4uw	3502	23	can	can	MD
cord-001835-0s7ok4uw	3502	24	create	create	VB
cord-001835-0s7ok4uw	3502	25	novel	novel	JJ
cord-001835-0s7ok4uw	3502	26	A3	A3	NNP
cord-001835-0s7ok4uw	3502	27	G	G	NNP
cord-001835-0s7ok4uw	3502	28	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3502	29	.	.	.
cord-001835-0s7ok4uw	3503	1	Using	use	VBG
cord-001835-0s7ok4uw	3503	2	structure	structure	NN
cord-001835-0s7ok4uw	3503	3	guided	guide	VBN
cord-001835-0s7ok4uw	3503	4	selection	selection	NN
cord-001835-0s7ok4uw	3503	5	,	,	,
cord-001835-0s7ok4uw	3503	6	residues	residue	NNS
cord-001835-0s7ok4uw	3503	7	in	in	IN
cord-001835-0s7ok4uw	3503	8	key	key	JJ
cord-001835-0s7ok4uw	3503	9	functional	functional	JJ
cord-001835-0s7ok4uw	3503	10	sites	site	NNS
cord-001835-0s7ok4uw	3503	11	that	that	WDT
cord-001835-0s7ok4uw	3503	12	are	be	VBP
cord-001835-0s7ok4uw	3503	13	amiable	amiable	JJ
cord-001835-0s7ok4uw	3503	14	to	to	IN
cord-001835-0s7ok4uw	3503	15	mutation	mutation	NN
cord-001835-0s7ok4uw	3503	16	will	will	MD
cord-001835-0s7ok4uw	3503	17	be	be	VB
cord-001835-0s7ok4uw	3503	18	chosen	choose	VBN
cord-001835-0s7ok4uw	3503	19	.	.	.
cord-001835-0s7ok4uw	3504	1	Individuals	individual	NNS
cord-001835-0s7ok4uw	3504	2	from	from	IN
cord-001835-0s7ok4uw	3504	3	the	the	DT
cord-001835-0s7ok4uw	3504	4	resulting	result	VBG
cord-001835-0s7ok4uw	3504	5	libraries	library	NNS
cord-001835-0s7ok4uw	3504	6	of	of	IN
cord-001835-0s7ok4uw	3504	7	mutants	mutant	NNS
cord-001835-0s7ok4uw	3504	8	will	will	MD
cord-001835-0s7ok4uw	3504	9	be	be	VB
cord-001835-0s7ok4uw	3504	10	selected	select	VBN
cord-001835-0s7ok4uw	3504	11	by	by	IN
cord-001835-0s7ok4uw	3504	12	directed	direct	VBN
cord-001835-0s7ok4uw	3504	13	evolution	evolution	NN
cord-001835-0s7ok4uw	3504	14	for	for	IN
cord-001835-0s7ok4uw	3504	15	desired	desire	VBN
cord-001835-0s7ok4uw	3504	16	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	3504	17	.	.	.
cord-001835-0s7ok4uw	3505	1	The	the	DT
cord-001835-0s7ok4uw	3505	2	resulting	result	VBG
cord-001835-0s7ok4uw	3505	3	A3	A3	NNP
cord-001835-0s7ok4uw	3505	4	G	G	NNP
cord-001835-0s7ok4uw	3505	5	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3505	6	will	will	MD
cord-001835-0s7ok4uw	3505	7	be	be	VB
cord-001835-0s7ok4uw	3505	8	examined	examine	VBN
cord-001835-0s7ok4uw	3505	9	for	for	IN
cord-001835-0s7ok4uw	3505	10	the	the	DT
cord-001835-0s7ok4uw	3505	11	relationship	relationship	NN
cord-001835-0s7ok4uw	3505	12	between	between	IN
cord-001835-0s7ok4uw	3505	13	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3505	14	structure	structure	NN
cord-001835-0s7ok4uw	3505	15	and	and	CC
cord-001835-0s7ok4uw	3505	16	function	function	NN
cord-001835-0s7ok4uw	3505	17	.	.	.
cord-001835-0s7ok4uw	3506	1	Such	such	JJ
cord-001835-0s7ok4uw	3506	2	engineered	engineer	VBN
cord-001835-0s7ok4uw	3506	3	A3	A3	NNP
cord-001835-0s7ok4uw	3506	4	G	G	NNP
cord-001835-0s7ok4uw	3506	5	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3506	6	could	could	MD
cord-001835-0s7ok4uw	3506	7	be	be	VB
cord-001835-0s7ok4uw	3506	8	targeted	target	VBN
cord-001835-0s7ok4uw	3506	9	to	to	TO
cord-001835-0s7ok4uw	3506	10	catalyse	catalyse	VB
cord-001835-0s7ok4uw	3506	11	the	the	DT
cord-001835-0s7ok4uw	3506	12	reversion	reversion	NN
cord-001835-0s7ok4uw	3506	13	of	of	IN
cord-001835-0s7ok4uw	3506	14	deleterious	deleterious	JJ
cord-001835-0s7ok4uw	3506	15	genetic	genetic	JJ
cord-001835-0s7ok4uw	3506	16	mutations	mutation	NNS
cord-001835-0s7ok4uw	3506	17	.	.	.
cord-001835-0s7ok4uw	3507	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	3507	2	,	,	,
cord-001835-0s7ok4uw	3507	3	engineered	engineer	VBN
cord-001835-0s7ok4uw	3507	4	A3	A3	NNP
cord-001835-0s7ok4uw	3507	5	G	G	NNP
cord-001835-0s7ok4uw	3507	6	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3507	7	could	could	MD
cord-001835-0s7ok4uw	3507	8	be	be	VB
cord-001835-0s7ok4uw	3507	9	used	use	VBN
cord-001835-0s7ok4uw	3507	10	in	in	IN
cord-001835-0s7ok4uw	3507	11	mutational	mutational	JJ
cord-001835-0s7ok4uw	3507	12	studies	study	NNS
cord-001835-0s7ok4uw	3507	13	that	that	WDT
cord-001835-0s7ok4uw	3507	14	call	call	VBP
cord-001835-0s7ok4uw	3507	15	for	for	IN
cord-001835-0s7ok4uw	3507	16	targeted	target	VBN
cord-001835-0s7ok4uw	3507	17	deamination	deamination	NN
cord-001835-0s7ok4uw	3507	18	along	along	IN
cord-001835-0s7ok4uw	3507	19	a	a	DT
cord-001835-0s7ok4uw	3507	20	DNA	dna	NN
cord-001835-0s7ok4uw	3507	21	strand	strand	NN
cord-001835-0s7ok4uw	3507	22	,	,	,
cord-001835-0s7ok4uw	3507	23	or	or	CC
cord-001835-0s7ok4uw	3507	24	mutational	mutational	JJ
cord-001835-0s7ok4uw	3507	25	studies	study	NNS
cord-001835-0s7ok4uw	3507	26	that	that	WDT
cord-001835-0s7ok4uw	3507	27	call	call	VBP
cord-001835-0s7ok4uw	3507	28	for	for	IN
cord-001835-0s7ok4uw	3507	29	unspecific	unspecific	JJ
cord-001835-0s7ok4uw	3507	30	and	and	CC
cord-001835-0s7ok4uw	3507	31	high	high	JJ
cord-001835-0s7ok4uw	3507	32	throughput	throughput	NN
cord-001835-0s7ok4uw	3507	33	DNA	dna	NN
cord-001835-0s7ok4uw	3507	34	deamination	deamination	NN
cord-001835-0s7ok4uw	3507	35	.	.	.
cord-001835-0s7ok4uw	3508	1	Engineering	engineering	NN
cord-001835-0s7ok4uw	3508	2	porous	porous	JJ
cord-001835-0s7ok4uw	3508	3	protein	protein	NN
cord-001835-0s7ok4uw	3508	4	crystals	crystal	NNS
cord-001835-0s7ok4uw	3508	5	as	as	IN
cord-001835-0s7ok4uw	3508	6	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3508	7	for	for	IN
cord-001835-0s7ok4uw	3508	8	programmed	program	VBN
cord-001835-0s7ok4uw	3508	9	assembly	assembly	NN
cord-001835-0s7ok4uw	3508	10	Thaddaus	Thaddaus	NNP
cord-001835-0s7ok4uw	3508	11	Huber	Huber	NNP
cord-001835-0s7ok4uw	3508	12	1	1	CD
cord-001835-0s7ok4uw	3508	13	,	,	,
cord-001835-0s7ok4uw	3508	14	Luke	Luke	NNP
cord-001835-0s7ok4uw	3508	15	Hartje	Hartje	NNP
cord-001835-0s7ok4uw	3508	16	1	1	CD
cord-001835-0s7ok4uw	3509	1	,	,	,
cord-001835-0s7ok4uw	3509	2	Christopher	Christopher	NNP
cord-001835-0s7ok4uw	3509	3	Snow	Snow	NNP
cord-001835-0s7ok4uw	3509	4	1	1	CD
cord-001835-0s7ok4uw	3509	5	1	1	CD
cord-001835-0s7ok4uw	3509	6	A	a	DT
cord-001835-0s7ok4uw	3509	7	key	key	JJ
cord-001835-0s7ok4uw	3509	8	motivation	motivation	NN
cord-001835-0s7ok4uw	3509	9	for	for	IN
cord-001835-0s7ok4uw	3509	10	nano	nano	NN
cord-001835-0s7ok4uw	3509	11	-	-	HYPH
cord-001835-0s7ok4uw	3509	12	biotechnology	biotechnology	NN
cord-001835-0s7ok4uw	3509	13	efforts	effort	NNS
cord-001835-0s7ok4uw	3509	14	is	be	VBZ
cord-001835-0s7ok4uw	3509	15	the	the	DT
cord-001835-0s7ok4uw	3509	16	creation	creation	NN
cord-001835-0s7ok4uw	3509	17	of	of	IN
cord-001835-0s7ok4uw	3509	18	designer	designer	NN
cord-001835-0s7ok4uw	3509	19	materials	material	NNS
cord-001835-0s7ok4uw	3509	20	in	in	IN
cord-001835-0s7ok4uw	3509	21	which	which	WDT
cord-001835-0s7ok4uw	3509	22	the	the	DT
cord-001835-0s7ok4uw	3509	23	assembly	assembly	NN
cord-001835-0s7ok4uw	3509	24	acts	act	VBZ
cord-001835-0s7ok4uw	3509	25	to	to	TO
cord-001835-0s7ok4uw	3509	26	organize	organize	VB
cord-001835-0s7ok4uw	3509	27	functional	functional	JJ
cord-001835-0s7ok4uw	3509	28	domains	domain	NNS
cord-001835-0s7ok4uw	3509	29	in	in	IN
cord-001835-0s7ok4uw	3509	30	three	three	CD
cord-001835-0s7ok4uw	3509	31	dimensions	dimension	NNS
cord-001835-0s7ok4uw	3509	32	.	.	.
cord-001835-0s7ok4uw	3510	1	Crystalline	crystalline	JJ
cord-001835-0s7ok4uw	3510	2	materials	material	NNS
cord-001835-0s7ok4uw	3510	3	are	be	VBP
cord-001835-0s7ok4uw	3510	4	ideal	ideal	JJ
cord-001835-0s7ok4uw	3510	5	from	from	IN
cord-001835-0s7ok4uw	3510	6	the	the	DT
cord-001835-0s7ok4uw	3510	7	validation	validation	NN
cord-001835-0s7ok4uw	3510	8	perspective	perspective	NN
cord-001835-0s7ok4uw	3510	9	because	because	IN
cord-001835-0s7ok4uw	3510	10	X	x	NN
cord-001835-0s7ok4uw	3510	11	-	-	NN
cord-001835-0s7ok4uw	3510	12	ray	ray	NN
cord-001835-0s7ok4uw	3510	13	diffraction	diffraction	NN
cord-001835-0s7ok4uw	3510	14	can	can	MD
cord-001835-0s7ok4uw	3510	15	elucidate	elucidate	VB
cord-001835-0s7ok4uw	3510	16	the	the	DT
cord-001835-0s7ok4uw	3510	17	atomic	atomic	JJ
cord-001835-0s7ok4uw	3510	18	structure	structure	NN
cord-001835-0s7ok4uw	3510	19	.	.	.
cord-001835-0s7ok4uw	3511	1	Relatively	relatively	RB
cord-001835-0s7ok4uw	3511	2	little	little	JJ
cord-001835-0s7ok4uw	3511	3	work	work	NN
cord-001835-0s7ok4uw	3511	4	has	have	VBZ
cord-001835-0s7ok4uw	3511	5	focused	focus	VBN
cord-001835-0s7ok4uw	3511	6	on	on	IN
cord-001835-0s7ok4uw	3511	7	engineering	engineering	NN
cord-001835-0s7ok4uw	3511	8	protein	protein	NN
cord-001835-0s7ok4uw	3511	9	crystals	crystal	NNS
cord-001835-0s7ok4uw	3511	10	as	as	IN
cord-001835-0s7ok4uw	3511	11	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3511	12	for	for	IN
cord-001835-0s7ok4uw	3511	13	nanotechnology	nanotechnology	NN
cord-001835-0s7ok4uw	3511	14	,	,	,
cord-001835-0s7ok4uw	3511	15	due	due	IN
cord-001835-0s7ok4uw	3511	16	to	to	IN
cord-001835-0s7ok4uw	3511	17	the	the	DT
cord-001835-0s7ok4uw	3511	18	technical	technical	JJ
cord-001835-0s7ok4uw	3511	19	challenges	challenge	NNS
cord-001835-0s7ok4uw	3511	20	of	of	IN
cord-001835-0s7ok4uw	3511	21	coaxing	coax	VBG
cord-001835-0s7ok4uw	3511	22	typical	typical	JJ
cord-001835-0s7ok4uw	3511	23	proteins	protein	NNS
cord-001835-0s7ok4uw	3511	24	into	into	IN
cord-001835-0s7ok4uw	3511	25	crystallizing	crystallize	VBG
cord-001835-0s7ok4uw	3511	26	,	,	,
cord-001835-0s7ok4uw	3511	27	and	and	CC
cord-001835-0s7ok4uw	3511	28	the	the	DT
cord-001835-0s7ok4uw	3511	29	likelihood	likelihood	NN
cord-001835-0s7ok4uw	3511	30	of	of	IN
cord-001835-0s7ok4uw	3511	31	disrupting	disrupt	VBG
cord-001835-0s7ok4uw	3511	32	the	the	DT
cord-001835-0s7ok4uw	3511	33	crystallization	crystallization	NN
cord-001835-0s7ok4uw	3511	34	process	process	NN
cord-001835-0s7ok4uw	3511	35	if	if	IN
cord-001835-0s7ok4uw	3511	36	changes	change	NNS
cord-001835-0s7ok4uw	3511	37	are	be	VBP
cord-001835-0s7ok4uw	3511	38	made	make	VBN
cord-001835-0s7ok4uw	3511	39	to	to	IN
cord-001835-0s7ok4uw	3511	40	the	the	DT
cord-001835-0s7ok4uw	3511	41	monomers	monomer	NNS
cord-001835-0s7ok4uw	3511	42	.	.	.
cord-001835-0s7ok4uw	3512	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3512	2	have	have	VBP
cord-001835-0s7ok4uw	3512	3	circumvented	circumvent	VBN
cord-001835-0s7ok4uw	3512	4	these	these	DT
cord-001835-0s7ok4uw	3512	5	limitations	limitation	NNS
cord-001835-0s7ok4uw	3512	6	by	by	IN
cord-001835-0s7ok4uw	3512	7	installing	instal	VBG
cord-001835-0s7ok4uw	3512	8	guest	guest	NN
cord-001835-0s7ok4uw	3512	9	protein	protein	NN
cord-001835-0s7ok4uw	3512	10	domains	domain	NNS
cord-001835-0s7ok4uw	3512	11	within	within	IN
cord-001835-0s7ok4uw	3512	12	engineered	engineer	VBN
cord-001835-0s7ok4uw	3512	13	porous	porous	JJ
cord-001835-0s7ok4uw	3512	14	crystals	crystal	NNS
cord-001835-0s7ok4uw	3512	15	(	(	-LRB-
cord-001835-0s7ok4uw	3512	16	13	13	CD
cord-001835-0s7ok4uw	3512	17	nm	nm	NNP
cord-001835-0s7ok4uw	3512	18	pore	pore	NN
cord-001835-0s7ok4uw	3512	19	diameter	diameter	NN
cord-001835-0s7ok4uw	3512	20	)	)	-RRB-
cord-001835-0s7ok4uw	3512	21	that	that	WDT
cord-001835-0s7ok4uw	3512	22	have	have	VBP
cord-001835-0s7ok4uw	3512	23	been	be	VBN
cord-001835-0s7ok4uw	3512	24	rendered	render	VBN
cord-001835-0s7ok4uw	3512	25	robust	robust	JJ
cord-001835-0s7ok4uw	3512	26	using	use	VBG
cord-001835-0s7ok4uw	3512	27	covalent	covalent	JJ
cord-001835-0s7ok4uw	3512	28	crosslinks	crosslink	NNS
cord-001835-0s7ok4uw	3512	29	.	.	.
cord-001835-0s7ok4uw	3513	1	The	the	DT
cord-001835-0s7ok4uw	3513	2	retention	retention	NN
cord-001835-0s7ok4uw	3513	3	of	of	IN
cord-001835-0s7ok4uw	3513	4	the	the	DT
cord-001835-0s7ok4uw	3513	5	scaffold	scaffold	NN
cord-001835-0s7ok4uw	3513	6	structure	structure	NN
cord-001835-0s7ok4uw	3513	7	despite	despite	IN
cord-001835-0s7ok4uw	3513	8	changes	change	NNS
cord-001835-0s7ok4uw	3513	9	to	to	IN
cord-001835-0s7ok4uw	3513	10	the	the	DT
cord-001835-0s7ok4uw	3513	11	solution	solution	NN
cord-001835-0s7ok4uw	3513	12	conditions	condition	NNS
cord-001835-0s7ok4uw	3513	13	and	and	CC
cord-001835-0s7ok4uw	3513	14	macromolecule	macromolecule	NN
cord-001835-0s7ok4uw	3513	15	uptake	uptake	NN
cord-001835-0s7ok4uw	3513	16	can	can	MD
cord-001835-0s7ok4uw	3513	17	be	be	VB
cord-001835-0s7ok4uw	3513	18	validated	validate	VBN
cord-001835-0s7ok4uw	3513	19	through	through	IN
cord-001835-0s7ok4uw	3513	20	X	x	NN
cord-001835-0s7ok4uw	3513	21	-	-	NN
cord-001835-0s7ok4uw	3513	22	ray	ray	NN
cord-001835-0s7ok4uw	3513	23	diffraction	diffraction	NN
cord-001835-0s7ok4uw	3513	24	.	.	.
cord-001835-0s7ok4uw	3514	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3514	2	have	have	VBP
cord-001835-0s7ok4uw	3514	3	engineered	engineer	VBN
cord-001835-0s7ok4uw	3514	4	scaffold	scaffold	NN
cord-001835-0s7ok4uw	3514	5	crystals	crystal	NNS
cord-001835-0s7ok4uw	3514	6	for	for	IN
cord-001835-0s7ok4uw	3514	7	the	the	DT
cord-001835-0s7ok4uw	3514	8	non	non	JJ
cord-001835-0s7ok4uw	3514	9	-	-	JJ
cord-001835-0s7ok4uw	3514	10	covalent	covalent	JJ
cord-001835-0s7ok4uw	3514	11	and	and	CC
cord-001835-0s7ok4uw	3514	12	covalent	covalent	JJ
cord-001835-0s7ok4uw	3514	13	capture	capture	NN
cord-001835-0s7ok4uw	3514	14	of	of	IN
cord-001835-0s7ok4uw	3514	15	guest	guest	NN
cord-001835-0s7ok4uw	3514	16	macromolecules	macromolecule	NNS
cord-001835-0s7ok4uw	3514	17	.	.	.
cord-001835-0s7ok4uw	3515	1	By	by	IN
cord-001835-0s7ok4uw	3515	2	controlling	control	VBG
cord-001835-0s7ok4uw	3515	3	the	the	DT
cord-001835-0s7ok4uw	3515	4	reversible	reversible	JJ
cord-001835-0s7ok4uw	3515	5	loading	loading	NN
cord-001835-0s7ok4uw	3515	6	and	and	CC
cord-001835-0s7ok4uw	3515	7	release	release	NN
cord-001835-0s7ok4uw	3515	8	,	,	,
cord-001835-0s7ok4uw	3515	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	3515	10	can	can	MD
cord-001835-0s7ok4uw	3515	11	prepare	prepare	VB
cord-001835-0s7ok4uw	3515	12	"	"	``
cord-001835-0s7ok4uw	3515	13	integrated	integrate	VBN
cord-001835-0s7ok4uw	3515	14	"	"	''
cord-001835-0s7ok4uw	3515	15	crystals	crystal	NNS
cord-001835-0s7ok4uw	3515	16	with	with	IN
cord-001835-0s7ok4uw	3515	17	spatially	spatially	RB
cord-001835-0s7ok4uw	3515	18	segregated	segregated	JJ
cord-001835-0s7ok4uw	3515	19	guest	guest	NN
cord-001835-0s7ok4uw	3515	20	loading	loading	NN
cord-001835-0s7ok4uw	3515	21	patterns	pattern	NNS
cord-001835-0s7ok4uw	3515	22	.	.	.
cord-001835-0s7ok4uw	3516	1	As	as	IN
cord-001835-0s7ok4uw	3516	2	assessed	assess	VBN
cord-001835-0s7ok4uw	3516	3	using	use	VBG
cord-001835-0s7ok4uw	3516	4	confocal	confocal	JJ
cord-001835-0s7ok4uw	3516	5	microscopy	microscopy	NNS
cord-001835-0s7ok4uw	3516	6	,	,	,
cord-001835-0s7ok4uw	3516	7	such	such	JJ
cord-001835-0s7ok4uw	3516	8	host	host	NN
cord-001835-0s7ok4uw	3516	9	-	-	HYPH
cord-001835-0s7ok4uw	3516	10	guest	guest	NN
cord-001835-0s7ok4uw	3516	11	crystals	crystal	NNS
cord-001835-0s7ok4uw	3516	12	are	be	VBP
cord-001835-0s7ok4uw	3516	13	highly	highly	RB
cord-001835-0s7ok4uw	3516	14	stable	stable	JJ
cord-001835-0s7ok4uw	3516	15	.	.	.
cord-001835-0s7ok4uw	3517	1	Ultimately	ultimately	RB
cord-001835-0s7ok4uw	3517	2	,	,	,
cord-001835-0s7ok4uw	3517	3	the	the	DT
cord-001835-0s7ok4uw	3517	4	resulting	result	VBG
cord-001835-0s7ok4uw	3517	5	crystals	crystal	NNS
cord-001835-0s7ok4uw	3517	6	may	may	MD
cord-001835-0s7ok4uw	3517	7	serve	serve	VB
cord-001835-0s7ok4uw	3517	8	as	as	IN
cord-001835-0s7ok4uw	3517	9	a	a	DT
cord-001835-0s7ok4uw	3517	10	robust	robust	JJ
cord-001835-0s7ok4uw	3517	11	alternative	alternative	NN
cord-001835-0s7ok4uw	3517	12	to	to	IN
cord-001835-0s7ok4uw	3517	13	DNA	dna	NN
cord-001835-0s7ok4uw	3517	14	assemblies	assembly	NNS
cord-001835-0s7ok4uw	3517	15	for	for	IN
cord-001835-0s7ok4uw	3517	16	the	the	DT
cord-001835-0s7ok4uw	3517	17	programmed	programmed	JJ
cord-001835-0s7ok4uw	3517	18	placement	placement	NN
cord-001835-0s7ok4uw	3517	19	of	of	IN
cord-001835-0s7ok4uw	3517	20	macromolecules	macromolecule	NNS
cord-001835-0s7ok4uw	3517	21	within	within	IN
cord-001835-0s7ok4uw	3517	22	materials	material	NNS
cord-001835-0s7ok4uw	3517	23	.	.	.
cord-001835-0s7ok4uw	3518	1	Engineering	engineer	VBG
cord-001835-0s7ok4uw	3518	2	ultrasensitive	ultrasensitive	JJ
cord-001835-0s7ok4uw	3518	3	protein	protein	NN
cord-001835-0s7ok4uw	3518	4	probes	probe	NNS
cord-001835-0s7ok4uw	3518	5	of	of	IN
cord-001835-0s7ok4uw	3518	6	voltage	voltage	NN
cord-001835-0s7ok4uw	3518	7	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3518	8	for	for	IN
cord-001835-0s7ok4uw	3518	9	imaging	image	VBG
cord-001835-0s7ok4uw	3518	10	neural	neural	JJ
cord-001835-0s7ok4uw	3518	11	activity	activity	NN
cord-001835-0s7ok4uw	3518	12	in	in	IN
cord-001835-0s7ok4uw	3518	13	vivo	vivo	NN
cord-001835-0s7ok4uw	3519	1	Francois	Francois	NNP
cord-001835-0s7ok4uw	3519	2	St	St	NNP
cord-001835-0s7ok4uw	3519	3	-	-	HYPH
cord-001835-0s7ok4uw	3519	4	Pierre	Pierre	NNP
cord-001835-0s7ok4uw	3519	5	1,2	1,2	CD
cord-001835-0s7ok4uw	3519	6	,	,	,
cord-001835-0s7ok4uw	3519	7	Michael	Michael	NNP
cord-001835-0s7ok4uw	3519	8	Pan	Pan	NNP
cord-001835-0s7ok4uw	3519	9	1,2	1,2	NNP
cord-001835-0s7ok4uw	3519	10	,	,	,
cord-001835-0s7ok4uw	3519	11	Helen	Helen	NNP
cord-001835-0s7ok4uw	3519	12	Yang	Yang	NNP
cord-001835-0s7ok4uw	3519	13	3	3	CD
cord-001835-0s7ok4uw	3519	14	,	,	,
cord-001835-0s7ok4uw	3519	15	Xiaozhe	Xiaozhe	NNP
cord-001835-0s7ok4uw	3519	16	Ding	Ding	NNP
cord-001835-0s7ok4uw	3519	17	1,2	1,2	CD
cord-001835-0s7ok4uw	3519	18	,	,	,
cord-001835-0s7ok4uw	3519	19	Ying	Ying	NNP
cord-001835-0s7ok4uw	3519	20	Yang	Yang	NNP
cord-001835-0s7ok4uw	3519	21	1,2	1,2	CD
cord-001835-0s7ok4uw	3519	22	,	,	,
cord-001835-0s7ok4uw	3519	23	Thomas	Thomas	NNP
cord-001835-0s7ok4uw	3519	24	Clandinin	Clandinin	NNP
cord-001835-0s7ok4uw	3519	25	3	3	CD
cord-001835-0s7ok4uw	3519	26	,	,	,
cord-001835-0s7ok4uw	3520	1	Michael	Michael	NNP
cord-001835-0s7ok4uw	3520	2	Lin	Lin	NNP
cord-001835-0s7ok4uw	3520	3	1,2	1,2	CD
cord-001835-0s7ok4uw	3520	4	1	1	CD
cord-001835-0s7ok4uw	3520	5	Department	Department	NNP
cord-001835-0s7ok4uw	3520	6	of	of	IN
cord-001835-0s7ok4uw	3520	7	Bioengineering	Bioengineering	NNP
cord-001835-0s7ok4uw	3520	8	,	,	,
cord-001835-0s7ok4uw	3520	9	Stanford	Stanford	NNP
cord-001835-0s7ok4uw	3520	10	University	University	NNP
cord-001835-0s7ok4uw	3520	11	,	,	,
cord-001835-0s7ok4uw	3520	12	2	2	CD
cord-001835-0s7ok4uw	3520	13	Department	Department	NNP
cord-001835-0s7ok4uw	3520	14	of	of	IN
cord-001835-0s7ok4uw	3520	15	Pediatrics	Pediatrics	NNP
cord-001835-0s7ok4uw	3520	16	,	,	,
cord-001835-0s7ok4uw	3520	17	Stanford	Stanford	NNP
cord-001835-0s7ok4uw	3520	18	University	University	NNP
cord-001835-0s7ok4uw	3521	1	,	,	,
cord-001835-0s7ok4uw	3521	2	3	3	CD
cord-001835-0s7ok4uw	3521	3	 	 	_SP
cord-001835-0s7ok4uw	3521	4	Nervous	nervous	JJ
cord-001835-0s7ok4uw	3521	5	systems	system	NNS
cord-001835-0s7ok4uw	3521	6	encode	encode	VBP
cord-001835-0s7ok4uw	3521	7	information	information	NN
cord-001835-0s7ok4uw	3521	8	as	as	IN
cord-001835-0s7ok4uw	3521	9	spatiotemporal	spatiotemporal	JJ
cord-001835-0s7ok4uw	3521	10	patterns	pattern	NNS
cord-001835-0s7ok4uw	3521	11	of	of	IN
cord-001835-0s7ok4uw	3521	12	membrane	membrane	NN
cord-001835-0s7ok4uw	3521	13	voltage	voltage	NN
cord-001835-0s7ok4uw	3521	14	transients	transient	NNS
cord-001835-0s7ok4uw	3521	15	,	,	,
cord-001835-0s7ok4uw	3521	16	so	so	RB
cord-001835-0s7ok4uw	3521	17	accurate	accurate	JJ
cord-001835-0s7ok4uw	3521	18	measurement	measurement	NN
cord-001835-0s7ok4uw	3521	19	of	of	IN
cord-001835-0s7ok4uw	3521	20	electrical	electrical	JJ
cord-001835-0s7ok4uw	3521	21	activity	activity	NN
cord-001835-0s7ok4uw	3521	22	has	have	VBZ
cord-001835-0s7ok4uw	3521	23	been	be	VBN
cord-001835-0s7ok4uw	3521	24	of	of	IN
cord-001835-0s7ok4uw	3521	25	long	long	RB
cord-001835-0s7ok4uw	3521	26	-	-	HYPH
cord-001835-0s7ok4uw	3521	27	standing	stand	VBG
cord-001835-0s7ok4uw	3521	28	interest	interest	NN
cord-001835-0s7ok4uw	3521	29	.	.	.
cord-001835-0s7ok4uw	3522	1	Recent	recent	JJ
cord-001835-0s7ok4uw	3522	2	engineering	engineering	NN
cord-001835-0s7ok4uw	3522	3	efforts	effort	NNS
cord-001835-0s7ok4uw	3522	4	have	have	VBP
cord-001835-0s7ok4uw	3522	5	improved	improve	VBN
cord-001835-0s7ok4uw	3522	6	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3522	7	ability	ability	NN
cord-001835-0s7ok4uw	3522	8	to	to	TO
cord-001835-0s7ok4uw	3522	9	monitor	monitor	VB
cord-001835-0s7ok4uw	3522	10	membrane	membrane	NN
cord-001835-0s7ok4uw	3522	11	voltage	voltage	NN
cord-001835-0s7ok4uw	3522	12	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3522	13	using	use	VBG
cord-001835-0s7ok4uw	3522	14	genetically	genetically	RB
cord-001835-0s7ok4uw	3522	15	encoded	encode	VBN
cord-001835-0s7ok4uw	3522	16	voltage	voltage	NN
cord-001835-0s7ok4uw	3522	17	indicators	indicator	NNS
cord-001835-0s7ok4uw	3522	18	.	.	.
cord-001835-0s7ok4uw	3523	1	In	in	IN
cord-001835-0s7ok4uw	3523	2	comparison	comparison	NN
cord-001835-0s7ok4uw	3523	3	with	with	IN
cord-001835-0s7ok4uw	3523	4	electrophysiological	electrophysiological	JJ
cord-001835-0s7ok4uw	3523	5	approaches	approach	NNS
cord-001835-0s7ok4uw	3523	6	,	,	,
cord-001835-0s7ok4uw	3523	7	such	such	JJ
cord-001835-0s7ok4uw	3523	8	protein	protein	NN
cord-001835-0s7ok4uw	3523	9	-	-	HYPH
cord-001835-0s7ok4uw	3523	10	based	base	VBN
cord-001835-0s7ok4uw	3523	11	indicators	indicator	NNS
cord-001835-0s7ok4uw	3523	12	can	can	MD
cord-001835-0s7ok4uw	3523	13	monitor	monitor	VB
cord-001835-0s7ok4uw	3523	14	many	many	JJ
cord-001835-0s7ok4uw	3523	15	genetically	genetically	RB
cord-001835-0s7ok4uw	3523	16	defined	define	VBN
cord-001835-0s7ok4uw	3523	17	neurons	neuron	NNS
cord-001835-0s7ok4uw	3523	18	simultaneously	simultaneously	RB
cord-001835-0s7ok4uw	3523	19	;	;	:
cord-001835-0s7ok4uw	3523	20	they	-PRON-	PRP
cord-001835-0s7ok4uw	3523	21	can	can	MD
cord-001835-0s7ok4uw	3523	22	also	also	RB
cord-001835-0s7ok4uw	3523	23	more	more	RBR
cord-001835-0s7ok4uw	3523	24	easily	easily	RB
cord-001835-0s7ok4uw	3523	25	measure	measure	VB
cord-001835-0s7ok4uw	3523	26	voltage	voltage	NN
cord-001835-0s7ok4uw	3523	27	changes	change	NNS
cord-001835-0s7ok4uw	3523	28	from	from	IN
cord-001835-0s7ok4uw	3523	29	subcellular	subcellular	JJ
cord-001835-0s7ok4uw	3523	30	compartments	compartment	NNS
cord-001835-0s7ok4uw	3523	31	such	such	JJ
cord-001835-0s7ok4uw	3523	32	as	as	IN
cord-001835-0s7ok4uw	3523	33	axons	axon	NNS
cord-001835-0s7ok4uw	3523	34	and	and	CC
cord-001835-0s7ok4uw	3523	35	dendrites	dendrite	NNS
cord-001835-0s7ok4uw	3523	36	.	.	.
cord-001835-0s7ok4uw	3524	1	Compared	compare	VBN
cord-001835-0s7ok4uw	3524	2	with	with	IN
cord-001835-0s7ok4uw	3524	3	genetically	genetically	RB
cord-001835-0s7ok4uw	3524	4	encoded	encode	VBN
cord-001835-0s7ok4uw	3524	5	calcium	calcium	NN
cord-001835-0s7ok4uw	3524	6	indicators	indicator	NNS
cord-001835-0s7ok4uw	3524	7	,	,	,
cord-001835-0s7ok4uw	3524	8	voltage	voltage	VB
cord-001835-0s7ok4uw	3524	9	sensors	sensor	NNS
cord-001835-0s7ok4uw	3524	10	enable	enable	VBP
cord-001835-0s7ok4uw	3524	11	a	a	DT
cord-001835-0s7ok4uw	3524	12	more	more	RBR
cord-001835-0s7ok4uw	3524	13	direct	direct	JJ
cord-001835-0s7ok4uw	3524	14	,	,	,
cord-001835-0s7ok4uw	3524	15	accurate	accurate	JJ
cord-001835-0s7ok4uw	3524	16	,	,	,
cord-001835-0s7ok4uw	3524	17	and	and	CC
cord-001835-0s7ok4uw	3524	18	rapid	rapid	JJ
cord-001835-0s7ok4uw	3524	19	readout	readout	NN
cord-001835-0s7ok4uw	3524	20	of	of	IN
cord-001835-0s7ok4uw	3524	21	membrane	membrane	NN
cord-001835-0s7ok4uw	3524	22	potential	potential	JJ
cord-001835-0s7ok4uw	3524	23	changes	change	NNS
cord-001835-0s7ok4uw	3524	24	.	.	.
cord-001835-0s7ok4uw	3525	1	However	however	RB
cord-001835-0s7ok4uw	3525	2	,	,	,
cord-001835-0s7ok4uw	3525	3	several	several	JJ
cord-001835-0s7ok4uw	3525	4	challenges	challenge	NNS
cord-001835-0s7ok4uw	3525	5	remain	remain	VBP
cord-001835-0s7ok4uw	3525	6	for	for	IN
cord-001835-0s7ok4uw	3525	7	in	in	IN
cord-001835-0s7ok4uw	3525	8	vivo	vivo	NN
cord-001835-0s7ok4uw	3525	9	voltage	voltage	NN
cord-001835-0s7ok4uw	3525	10	imaging	imaging	NN
cord-001835-0s7ok4uw	3525	11	with	with	IN
cord-001835-0s7ok4uw	3525	12	genetically	genetically	RB
cord-001835-0s7ok4uw	3525	13	encoded	encode	VBN
cord-001835-0s7ok4uw	3525	14	indicators	indicator	NNS
cord-001835-0s7ok4uw	3525	15	.	.	.
cord-001835-0s7ok4uw	3526	1	In	in	IN
cord-001835-0s7ok4uw	3526	2	particular	particular	JJ
cord-001835-0s7ok4uw	3526	3	,	,	,
cord-001835-0s7ok4uw	3526	4	current	current	JJ
cord-001835-0s7ok4uw	3526	5	voltage	voltage	NN
cord-001835-0s7ok4uw	3526	6	sensors	sensor	NNS
cord-001835-0s7ok4uw	3526	7	are	be	VBP
cord-001835-0s7ok4uw	3526	8	characterized	characterize	VBN
cord-001835-0s7ok4uw	3526	9	by	by	IN
cord-001835-0s7ok4uw	3526	10	insufficient	insufficient	JJ
cord-001835-0s7ok4uw	3526	11	sensitivity	sensitivity	NN
cord-001835-0s7ok4uw	3526	12	,	,	,
cord-001835-0s7ok4uw	3526	13	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	3526	14	,	,	,
cord-001835-0s7ok4uw	3526	15	and/or	and/or	CC
cord-001835-0s7ok4uw	3526	16	brightness	brightness	NN
cord-001835-0s7ok4uw	3526	17	to	to	TO
cord-001835-0s7ok4uw	3526	18	be	be	VB
cord-001835-0s7ok4uw	3526	19	true	true	JJ
cord-001835-0s7ok4uw	3526	20	optical	optical	JJ
cord-001835-0s7ok4uw	3526	21	replacements	replacement	NNS
cord-001835-0s7ok4uw	3526	22	for	for	IN
cord-001835-0s7ok4uw	3526	23	electrodes	electrode	NNS
cord-001835-0s7ok4uw	3526	24	in	in	IN
cord-001835-0s7ok4uw	3526	25	vivo	vivo	NN
cord-001835-0s7ok4uw	3526	26	.	.	.
cord-001835-0s7ok4uw	3527	1	As	as	IN
cord-001835-0s7ok4uw	3527	2	a	a	DT
cord-001835-0s7ok4uw	3527	3	first	first	JJ
cord-001835-0s7ok4uw	3527	4	step	step	NN
cord-001835-0s7ok4uw	3527	5	towards	towards	IN
cord-001835-0s7ok4uw	3527	6	addressing	address	VBG
cord-001835-0s7ok4uw	3527	7	these	these	DT
cord-001835-0s7ok4uw	3527	8	challenges	challenge	NNS
cord-001835-0s7ok4uw	3527	9	,	,	,
cord-001835-0s7ok4uw	3527	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	3527	11	sought	seek	VBD
cord-001835-0s7ok4uw	3527	12	to	to	TO
cord-001835-0s7ok4uw	3527	13	develop	develop	VB
cord-001835-0s7ok4uw	3527	14	new	new	JJ
cord-001835-0s7ok4uw	3527	15	voltage	voltage	NN
cord-001835-0s7ok4uw	3527	16	indicators	indicator	NNS
cord-001835-0s7ok4uw	3527	17	that	that	WDT
cord-001835-0s7ok4uw	3527	18	further	further	RB
cord-001835-0s7ok4uw	3527	19	improve	improve	VBP
cord-001835-0s7ok4uw	3527	20	upon	upon	IN
cord-001835-0s7ok4uw	3527	21	the	the	DT
cord-001835-0s7ok4uw	3527	22	performance	performance	NN
cord-001835-0s7ok4uw	3527	23	of	of	IN
cord-001835-0s7ok4uw	3527	24	the	the	DT
cord-001835-0s7ok4uw	3527	25	fast	fast	JJ
cord-001835-0s7ok4uw	3527	26	voltage	voltage	NN
cord-001835-0s7ok4uw	3527	27	sensor	sensor	NN
cord-001835-0s7ok4uw	3527	28	Accelerated	accelerate	VBN
cord-001835-0s7ok4uw	3527	29	Sensor	Sensor	NNP
cord-001835-0s7ok4uw	3527	30	of	of	IN
cord-001835-0s7ok4uw	3527	31	Action	Action	NNP
cord-001835-0s7ok4uw	3527	32	Potentials	potential	NNS
cord-001835-0s7ok4uw	3527	33	1	1	CD
cord-001835-0s7ok4uw	3527	34	(	(	-LRB-
cord-001835-0s7ok4uw	3527	35	ASAP1	asap1	NN
cord-001835-0s7ok4uw	3527	36	)	)	-RRB-
cord-001835-0s7ok4uw	3527	37	.	.	.
cord-001835-0s7ok4uw	3528	1	In	in	IN
cord-001835-0s7ok4uw	3528	2	ASAP1	asap1	NN
cord-001835-0s7ok4uw	3528	3	,	,	,
cord-001835-0s7ok4uw	3528	4	voltage	voltage	NN
cord-001835-0s7ok4uw	3528	5	-	-	HYPH
cord-001835-0s7ok4uw	3528	6	induced	induce	VBN
cord-001835-0s7ok4uw	3528	7	conformational	conformational	JJ
cord-001835-0s7ok4uw	3528	8	changes	change	NNS
cord-001835-0s7ok4uw	3528	9	in	in	IN
cord-001835-0s7ok4uw	3528	10	a	a	DT
cord-001835-0s7ok4uw	3528	11	natural	natural	JJ
cord-001835-0s7ok4uw	3528	12	voltage	voltage	NN
cord-001835-0s7ok4uw	3528	13	-	-	HYPH
cord-001835-0s7ok4uw	3528	14	sensing	sensing	NN
cord-001835-0s7ok4uw	3528	15	domain	domain	NN
cord-001835-0s7ok4uw	3528	16	perturb	perturb	VBP
cord-001835-0s7ok4uw	3528	17	the	the	DT
cord-001835-0s7ok4uw	3528	18	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3528	19	emission	emission	NN
cord-001835-0s7ok4uw	3528	20	of	of	IN
cord-001835-0s7ok4uw	3528	21	a	a	DT
cord-001835-0s7ok4uw	3528	22	covalently	covalently	RB
cord-001835-0s7ok4uw	3528	23	linked	link	VBN
cord-001835-0s7ok4uw	3528	24	green	green	JJ
cord-001835-0s7ok4uw	3528	25	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	3528	26	protein	protein	NN
cord-001835-0s7ok4uw	3528	27	(	(	-LRB-
cord-001835-0s7ok4uw	3528	28	GFP	GFP	NNP
cord-001835-0s7ok4uw	3528	29	)	)	-RRB-
cord-001835-0s7ok4uw	3528	30	.	.	.
cord-001835-0s7ok4uw	3529	1	Using	use	VBG
cord-001835-0s7ok4uw	3529	2	a	a	DT
cord-001835-0s7ok4uw	3529	3	structurebased	structurebased	JJ
cord-001835-0s7ok4uw	3529	4	approach	approach	NN
cord-001835-0s7ok4uw	3529	5	to	to	TO
cord-001835-0s7ok4uw	3529	6	guide	guide	VB
cord-001835-0s7ok4uw	3529	7	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	3529	8	,	,	,
cord-001835-0s7ok4uw	3529	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	3529	10	discovered	discover	VBD
cord-001835-0s7ok4uw	3529	11	several	several	JJ
cord-001835-0s7ok4uw	3529	12	amino	amino	NN
cord-001835-0s7ok4uw	3529	13	acids	acid	NNS
cord-001835-0s7ok4uw	3529	14	that	that	WDT
cord-001835-0s7ok4uw	3529	15	tune	tune	VBP
cord-001835-0s7ok4uw	3529	16	the	the	DT
cord-001835-0s7ok4uw	3529	17	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	3529	18	and	and	CC
cord-001835-0s7ok4uw	3529	19	voltage	voltage	VB
cord-001835-0s7ok4uw	3529	20	sensitivity	sensitivity	NN
cord-001835-0s7ok4uw	3529	21	of	of	IN
cord-001835-0s7ok4uw	3529	22	ASAP1	asap1	NN
cord-001835-0s7ok4uw	3529	23	.	.	.
cord-001835-0s7ok4uw	3530	1	These	these	DT
cord-001835-0s7ok4uw	3530	2	residues	residue	NNS
cord-001835-0s7ok4uw	3530	3	are	be	VBP
cord-001835-0s7ok4uw	3530	4	not	not	RB
cord-001835-0s7ok4uw	3530	5	only	only	RB
cord-001835-0s7ok4uw	3530	6	located	locate	VBN
cord-001835-0s7ok4uw	3530	7	in	in	IN
cord-001835-0s7ok4uw	3530	8	the	the	DT
cord-001835-0s7ok4uw	3530	9	voltage	voltage	NN
cord-001835-0s7ok4uw	3530	10	-	-	HYPH
cord-001835-0s7ok4uw	3530	11	sensing	sensing	NN
cord-001835-0s7ok4uw	3530	12	domain	domain	NN
cord-001835-0s7ok4uw	3530	13	,	,	,
cord-001835-0s7ok4uw	3530	14	but	but	CC
cord-001835-0s7ok4uw	3530	15	also	also	RB
cord-001835-0s7ok4uw	3530	16	in	in	IN
cord-001835-0s7ok4uw	3530	17	the	the	DT
cord-001835-0s7ok4uw	3530	18	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	3530	19	protein	protein	NN
cord-001835-0s7ok4uw	3530	20	and	and	CC
cord-001835-0s7ok4uw	3530	21	in	in	IN
cord-001835-0s7ok4uw	3530	22	the	the	DT
cord-001835-0s7ok4uw	3530	23	linkers	linker	NNS
cord-001835-0s7ok4uw	3530	24	bridging	bridge	VBG
cord-001835-0s7ok4uw	3530	25	sensing	sense	VBG
cord-001835-0s7ok4uw	3530	26	domain	domain	NN
cord-001835-0s7ok4uw	3530	27	and	and	CC
cord-001835-0s7ok4uw	3530	28	GFP	GFP	NNP
cord-001835-0s7ok4uw	3530	29	.	.	.
cord-001835-0s7ok4uw	3531	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3531	2	most	most	RBS
cord-001835-0s7ok4uw	3531	3	improved	improve	VBN
cord-001835-0s7ok4uw	3531	4	variant	variant	NN
cord-001835-0s7ok4uw	3531	5	,	,	,
cord-001835-0s7ok4uw	3531	6	ASAP2	ASAP2	NNS
cord-001835-0s7ok4uw	3531	7	,	,	,
cord-001835-0s7ok4uw	3531	8	exhibits	exhibit	VBZ
cord-001835-0s7ok4uw	3531	9	improved	improve	VBN
cord-001835-0s7ok4uw	3531	10	sensitivity	sensitivity	NN
cord-001835-0s7ok4uw	3531	11	to	to	TO
cord-001835-0s7ok4uw	3531	12	voltage	voltage	VB
cord-001835-0s7ok4uw	3531	13	transients	transient	NNS
cord-001835-0s7ok4uw	3531	14	such	such	JJ
cord-001835-0s7ok4uw	3531	15	as	as	IN
cord-001835-0s7ok4uw	3531	16	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	3531	17	action	action	NN
cord-001835-0s7ok4uw	3531	18	potentials	potential	NNS
cord-001835-0s7ok4uw	3531	19	and	and	CC
cord-001835-0s7ok4uw	3531	20	subthreshold	subthreshold	VBP
cord-001835-0s7ok4uw	3531	21	depolarizations	depolarization	NNS
cord-001835-0s7ok4uw	3531	22	.	.	.
cord-001835-0s7ok4uw	3532	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3532	2	sought	seek	VBD
cord-001835-0s7ok4uw	3532	3	to	to	TO
cord-001835-0s7ok4uw	3532	4	characterize	characterize	VB
cord-001835-0s7ok4uw	3532	5	the	the	DT
cord-001835-0s7ok4uw	3532	6	ability	ability	NN
cord-001835-0s7ok4uw	3532	7	of	of	IN
cord-001835-0s7ok4uw	3532	8	these	these	DT
cord-001835-0s7ok4uw	3532	9	new	new	JJ
cord-001835-0s7ok4uw	3532	10	voltage	voltage	NN
cord-001835-0s7ok4uw	3532	11	sensors	sensor	NNS
cord-001835-0s7ok4uw	3532	12	to	to	TO
cord-001835-0s7ok4uw	3532	13	monitor	monitor	VB
cord-001835-0s7ok4uw	3532	14	neural	neural	JJ
cord-001835-0s7ok4uw	3532	15	activity	activity	NN
cord-001835-0s7ok4uw	3532	16	in	in	IN
cord-001835-0s7ok4uw	3532	17	vivo	vivo	NN
cord-001835-0s7ok4uw	3532	18	using	use	VBG
cord-001835-0s7ok4uw	3532	19	laser	laser	NN
cord-001835-0s7ok4uw	3532	20	-	-	HYPH
cord-001835-0s7ok4uw	3532	21	scanning	scan	VBG
cord-001835-0s7ok4uw	3532	22	two	two	CD
cord-001835-0s7ok4uw	3532	23	-	-	HYPH
cord-001835-0s7ok4uw	3532	24	photon	photon	NN
cord-001835-0s7ok4uw	3532	25	microscopy	microscopy	NNS
cord-001835-0s7ok4uw	3532	26	,	,	,
cord-001835-0s7ok4uw	3532	27	a	a	DT
cord-001835-0s7ok4uw	3532	28	technique	technique	NN
cord-001835-0s7ok4uw	3532	29	that	that	WDT
cord-001835-0s7ok4uw	3532	30	allows	allow	VBZ
cord-001835-0s7ok4uw	3532	31	imaging	image	VBG
cord-001835-0s7ok4uw	3532	32	with	with	IN
cord-001835-0s7ok4uw	3532	33	lower	low	JJR
cord-001835-0s7ok4uw	3532	34	autofluorescence	autofluorescence	NNS
cord-001835-0s7ok4uw	3532	35	and	and	CC
cord-001835-0s7ok4uw	3532	36	deeper	deep	JJR
cord-001835-0s7ok4uw	3532	37	tissue	tissue	NN
cord-001835-0s7ok4uw	3532	38	penetration	penetration	NN
cord-001835-0s7ok4uw	3532	39	.	.	.
cord-001835-0s7ok4uw	3533	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3533	2	report	report	VBP
cord-001835-0s7ok4uw	3533	3	that	that	IN
cord-001835-0s7ok4uw	3533	4	ASAP	ASAP	NNP
cord-001835-0s7ok4uw	3533	5	sensors	sensor	NNS
cord-001835-0s7ok4uw	3533	6	were	be	VBD
cord-001835-0s7ok4uw	3533	7	able	able	JJ
cord-001835-0s7ok4uw	3533	8	report	report	NN
cord-001835-0s7ok4uw	3533	9	stimulus	stimulus	NN
cord-001835-0s7ok4uw	3533	10	-	-	HYPH
cord-001835-0s7ok4uw	3533	11	evoked	evoke	VBN
cord-001835-0s7ok4uw	3533	12	voltage	voltage	NN
cord-001835-0s7ok4uw	3533	13	responses	response	NNS
cord-001835-0s7ok4uw	3533	14	in	in	IN
cord-001835-0s7ok4uw	3533	15	axonal	axonal	JJ
cord-001835-0s7ok4uw	3533	16	termini	terminus	NNS
cord-001835-0s7ok4uw	3533	17	of	of	IN
cord-001835-0s7ok4uw	3533	18	the	the	DT
cord-001835-0s7ok4uw	3533	19	fly	fly	NN
cord-001835-0s7ok4uw	3533	20	visual	visual	JJ
cord-001835-0s7ok4uw	3533	21	interneuron	interneuron	NN
cord-001835-0s7ok4uw	3533	22	L2	l2	NN
cord-001835-0s7ok4uw	3533	23	.	.	.
cord-001835-0s7ok4uw	3534	1	ASAP	ASAP	NNP
cord-001835-0s7ok4uw	3534	2	sensors	sensor	NNS
cord-001835-0s7ok4uw	3534	3	enabled	enable	VBD
cord-001835-0s7ok4uw	3534	4	voltage	voltage	NN
cord-001835-0s7ok4uw	3534	5	imaging	imaging	NN
cord-001835-0s7ok4uw	3534	6	with	with	IN
cord-001835-0s7ok4uw	3534	7	dramatically	dramatically	RB
cord-001835-0s7ok4uw	3534	8	improved	improve	VBN
cord-001835-0s7ok4uw	3534	9	temporal	temporal	JJ
cord-001835-0s7ok4uw	3534	10	resolution	resolution	NN
cord-001835-0s7ok4uw	3534	11	compared	compare	VBN
cord-001835-0s7ok4uw	3534	12	to	to	IN
cord-001835-0s7ok4uw	3534	13	three	three	CD
cord-001835-0s7ok4uw	3534	14	recently	recently	RB
cord-001835-0s7ok4uw	3534	15	reported	report	VBD
cord-001835-0s7ok4uw	3534	16	calcium	calcium	NN
cord-001835-0s7ok4uw	3534	17	and	and	CC
cord-001835-0s7ok4uw	3534	18	voltage	voltage	NN
cord-001835-0s7ok4uw	3534	19	sensors	sensor	NNS
cord-001835-0s7ok4uw	3534	20	.	.	.
cord-001835-0s7ok4uw	3535	1	Overall	overall	RB
cord-001835-0s7ok4uw	3535	2	,	,	,
cord-001835-0s7ok4uw	3535	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3535	4	study	study	NN
cord-001835-0s7ok4uw	3535	5	reports	report	VBZ
cord-001835-0s7ok4uw	3535	6	novel	novel	NN
cord-001835-0s7ok4uw	3535	7	voltage	voltage	NN
cord-001835-0s7ok4uw	3535	8	indicators	indicator	NNS
cord-001835-0s7ok4uw	3535	9	with	with	IN
cord-001835-0s7ok4uw	3535	10	improved	improved	JJ
cord-001835-0s7ok4uw	3535	11	performance	performance	NN
cord-001835-0s7ok4uw	3535	12	and	and	CC
cord-001835-0s7ok4uw	3535	13	highlights	highlight	VBZ
cord-001835-0s7ok4uw	3535	14	how	how	WRB
cord-001835-0s7ok4uw	3535	15	specific	specific	JJ
cord-001835-0s7ok4uw	3535	16	amino	amino	JJ
cord-001835-0s7ok4uw	3535	17	acids	acid	NNS
cord-001835-0s7ok4uw	3535	18	can	can	MD
cord-001835-0s7ok4uw	3535	19	tune	tune	VB
cord-001835-0s7ok4uw	3535	20	the	the	DT
cord-001835-0s7ok4uw	3535	21	performance	performance	NN
cord-001835-0s7ok4uw	3535	22	of	of	IN
cord-001835-0s7ok4uw	3535	23	a	a	DT
cord-001835-0s7ok4uw	3535	24	proteinbased	proteinbased	JJ
cord-001835-0s7ok4uw	3535	25	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	3535	26	sensor	sensor	NN
cord-001835-0s7ok4uw	3535	27	.	.	.
cord-001835-0s7ok4uw	3536	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3536	2	anticipate	anticipate	VBP
cord-001835-0s7ok4uw	3536	3	that	that	IN
cord-001835-0s7ok4uw	3536	4	these	these	DT
cord-001835-0s7ok4uw	3536	5	results	result	NNS
cord-001835-0s7ok4uw	3536	6	will	will	MD
cord-001835-0s7ok4uw	3536	7	pave	pave	VB
cord-001835-0s7ok4uw	3536	8	the	the	DT
cord-001835-0s7ok4uw	3536	9	way	way	NN
cord-001835-0s7ok4uw	3536	10	for	for	IN
cord-001835-0s7ok4uw	3536	11	further	further	JJ
cord-001835-0s7ok4uw	3536	12	engineering	engineering	NN
cord-001835-0s7ok4uw	3536	13	of	of	IN
cord-001835-0s7ok4uw	3536	14	voltage	voltage	NN
cord-001835-0s7ok4uw	3536	15	sensing	sensing	NN
cord-001835-0s7ok4uw	3536	16	proteins	protein	NNS
cord-001835-0s7ok4uw	3536	17	,	,	,
cord-001835-0s7ok4uw	3536	18	and	and	CC
cord-001835-0s7ok4uw	3536	19	that	that	IN
cord-001835-0s7ok4uw	3536	20	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3536	21	new	new	JJ
cord-001835-0s7ok4uw	3536	22	sensor	sensor	NN
cord-001835-0s7ok4uw	3536	23	ASAP2	asap2	PRP
cord-001835-0s7ok4uw	3536	24	will	will	MD
cord-001835-0s7ok4uw	3536	25	facilitate	facilitate	VB
cord-001835-0s7ok4uw	3536	26	current	current	JJ
cord-001835-0s7ok4uw	3536	27	and	and	CC
cord-001835-0s7ok4uw	3536	28	future	future	JJ
cord-001835-0s7ok4uw	3536	29	efforts	effort	NNS
cord-001835-0s7ok4uw	3536	30	to	to	TO
cord-001835-0s7ok4uw	3536	31	understand	understand	VB
cord-001835-0s7ok4uw	3536	32	how	how	WRB
cord-001835-0s7ok4uw	3536	33	neural	neural	JJ
cord-001835-0s7ok4uw	3536	34	circuits	circuit	NNS
cord-001835-0s7ok4uw	3536	35	represent	represent	VBP
cord-001835-0s7ok4uw	3536	36	and	and	CC
cord-001835-0s7ok4uw	3536	37	transform	transform	VBP
cord-001835-0s7ok4uw	3536	38	information	information	NN
cord-001835-0s7ok4uw	3536	39	.	.	.
cord-001835-0s7ok4uw	3537	1	Assembly	Assembly	NNP
cord-001835-0s7ok4uw	3537	2	of	of	IN
cord-001835-0s7ok4uw	3537	3	armadillo	armadillo	NN
cord-001835-0s7ok4uw	3537	4	repeat	repeat	NN
cord-001835-0s7ok4uw	3537	5	proteins	protein	NNS
cord-001835-0s7ok4uw	3537	6	from	from	IN
cord-001835-0s7ok4uw	3537	7	complementary	complementary	JJ
cord-001835-0s7ok4uw	3537	8	fragments	fragment	NNS
cord-001835-0s7ok4uw	3537	9	Erich	Erich	NNP
cord-001835-0s7ok4uw	3537	10	Michel	Michel	NNP
cord-001835-0s7ok4uw	3537	11	1	1	CD
cord-001835-0s7ok4uw	3537	12	,	,	,
cord-001835-0s7ok4uw	3537	13	Randall	Randall	NNP
cord-001835-0s7ok4uw	3537	14	Watson	Watson	NNP
cord-001835-0s7ok4uw	3537	15	1	1	CD
cord-001835-0s7ok4uw	3537	16	,	,	,
cord-001835-0s7ok4uw	3537	17	Martin	Martin	NNP
cord-001835-0s7ok4uw	3537	18	Christen	Christen	NNP
cord-001835-0s7ok4uw	3537	19	1	1	CD
cord-001835-0s7ok4uw	3537	20	,	,	,
cord-001835-0s7ok4uw	3537	21	Fabian	Fabian	NNP
cord-001835-0s7ok4uw	3537	22	Bumback	Bumback	NNP
cord-001835-0s7ok4uw	3537	23	3	3	CD
cord-001835-0s7ok4uw	3537	24	,	,	,
cord-001835-0s7ok4uw	3537	25	Andreas	Andreas	NNP
cord-001835-0s7ok4uw	3537	26	Pl€	pl€	NN
cord-001835-0s7ok4uw	3537	27	uckthun	uckthun	NNP
cord-001835-0s7ok4uw	3537	28	2	2	CD
cord-001835-0s7ok4uw	3537	29	,	,	,
cord-001835-0s7ok4uw	3537	30	Oliver	Oliver	NNP
cord-001835-0s7ok4uw	3537	31	Zerbe	Zerbe	NNP
cord-001835-0s7ok4uw	3537	32	1	1	CD
cord-001835-0s7ok4uw	3537	33	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	3537	34	that	that	IN
cord-001835-0s7ok4uw	3537	35	complementary	complementary	JJ
cord-001835-0s7ok4uw	3537	36	fragments	fragment	NNS
cord-001835-0s7ok4uw	3537	37	of	of	IN
cord-001835-0s7ok4uw	3537	38	a	a	DT
cord-001835-0s7ok4uw	3537	39	designed	design	VBN
cord-001835-0s7ok4uw	3537	40	consensus	consensus	NN
cord-001835-0s7ok4uw	3537	41	Armadillo	Armadillo	NNP
cord-001835-0s7ok4uw	3537	42	repeat	repeat	NN
cord-001835-0s7ok4uw	3537	43	protein	protein	NN
cord-001835-0s7ok4uw	3537	44	(	(	-LRB-
cord-001835-0s7ok4uw	3537	45	ArmRP	armrp	NN
cord-001835-0s7ok4uw	3537	46	)	)	-RRB-
cord-001835-0s7ok4uw	3537	47	recognize	recognize	VB
cord-001835-0s7ok4uw	3537	48	each	each	DT
cord-001835-0s7ok4uw	3537	49	other	other	JJ
cord-001835-0s7ok4uw	3537	50	[	[	-LRB-
cord-001835-0s7ok4uw	3537	51	1	1	CD
cord-001835-0s7ok4uw	3537	52	]	]	-RRB-
cord-001835-0s7ok4uw	3537	53	.	.	.
cord-001835-0s7ok4uw	3538	1	The	the	DT
cord-001835-0s7ok4uw	3538	2	two	two	CD
cord-001835-0s7ok4uw	3538	3	fragments	fragment	NNS
cord-001835-0s7ok4uw	3539	1	YM2	YM2	NNP
cord-001835-0s7ok4uw	3539	2	:	:	:
cord-001835-0s7ok4uw	3539	3	MA	MA	NNP
cord-001835-0s7ok4uw	3539	4	,	,	,
cord-001835-0s7ok4uw	3539	5	in	in	IN
cord-001835-0s7ok4uw	3539	6	which	which	WDT
cord-001835-0s7ok4uw	3539	7	Y	Y	NNP
cord-001835-0s7ok4uw	3539	8	,	,	,
cord-001835-0s7ok4uw	3539	9	M	M	NNP
cord-001835-0s7ok4uw	3539	10	and	and	CC
cord-001835-0s7ok4uw	3539	11	A	A	NNP
cord-001835-0s7ok4uw	3539	12	denote	denote	VBP
cord-001835-0s7ok4uw	3539	13	the	the	DT
cord-001835-0s7ok4uw	3539	14	N	n	CD
cord-001835-0s7ok4uw	3539	15	-	-	HYPH
cord-001835-0s7ok4uw	3539	16	cap	cap	NN
cord-001835-0s7ok4uw	3539	17	,	,	,
cord-001835-0s7ok4uw	3539	18	internal	internal	JJ
cord-001835-0s7ok4uw	3539	19	repeats	repeat	NNS
cord-001835-0s7ok4uw	3539	20	and	and	CC
cord-001835-0s7ok4uw	3539	21	the	the	DT
cord-001835-0s7ok4uw	3539	22	C	C	NNP
cord-001835-0s7ok4uw	3539	23	-	-	HYPH
cord-001835-0s7ok4uw	3539	24	cap	cap	NN
cord-001835-0s7ok4uw	3539	25	,	,	,
cord-001835-0s7ok4uw	3539	26	respectively	respectively	RB
cord-001835-0s7ok4uw	3539	27	,	,	,
cord-001835-0s7ok4uw	3539	28	form	form	VB
cord-001835-0s7ok4uw	3539	29	a	a	DT
cord-001835-0s7ok4uw	3539	30	1:1	1:1	CD
cord-001835-0s7ok4uw	3539	31	complex	complex	NN
cord-001835-0s7ok4uw	3539	32	with	with	IN
cord-001835-0s7ok4uw	3539	33	a	a	DT
cord-001835-0s7ok4uw	3539	34	nanomolar	nanomolar	JJ
cord-001835-0s7ok4uw	3539	35	dissociation	dissociation	NN
cord-001835-0s7ok4uw	3539	36	constant	constant	NN
cord-001835-0s7ok4uw	3539	37	,	,	,
cord-001835-0s7ok4uw	3539	38	which	which	WDT
cord-001835-0s7ok4uw	3539	39	is	be	VBZ
cord-001835-0s7ok4uw	3539	40	essentially	essentially	RB
cord-001835-0s7ok4uw	3539	41	identical	identical	JJ
cord-001835-0s7ok4uw	3539	42	to	to	IN
cord-001835-0s7ok4uw	3539	43	the	the	DT
cord-001835-0s7ok4uw	3539	44	crystal	crystal	JJ
cord-001835-0s7ok4uw	3539	45	structure	structure	NN
cord-001835-0s7ok4uw	3539	46	of	of	IN
cord-001835-0s7ok4uw	3539	47	the	the	DT
cord-001835-0s7ok4uw	3539	48	continuous	continuous	JJ
cord-001835-0s7ok4uw	3539	49	YM3A	YM3A	NNP
cord-001835-0s7ok4uw	3539	50	protein	protein	NN
cord-001835-0s7ok4uw	3539	51	.	.	.
cord-001835-0s7ok4uw	3540	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3540	2	further	further	RB
cord-001835-0s7ok4uw	3540	3	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	3540	4	that	that	WDT
cord-001835-0s7ok4uw	3540	5	structurally	structurally	RB
cord-001835-0s7ok4uw	3540	6	intact	intact	JJ
cord-001835-0s7ok4uw	3540	7	Armadillo	Armadillo	NNP
cord-001835-0s7ok4uw	3540	8	repeat	repeat	NN
cord-001835-0s7ok4uw	3540	9	protein	protein	NN
cord-001835-0s7ok4uw	3540	10	complexes	complex	NNS
cord-001835-0s7ok4uw	3540	11	can	can	MD
cord-001835-0s7ok4uw	3540	12	be	be	VB
cord-001835-0s7ok4uw	3540	13	reconstituted	reconstitute	VBN
cord-001835-0s7ok4uw	3540	14	from	from	IN
cord-001835-0s7ok4uw	3540	15	fragments	fragment	NNS
cord-001835-0s7ok4uw	3540	16	obtained	obtain	VBN
cord-001835-0s7ok4uw	3540	17	at	at	IN
cord-001835-0s7ok4uw	3540	18	various	various	JJ
cord-001835-0s7ok4uw	3540	19	split	split	NN
cord-001835-0s7ok4uw	3540	20	sites	site	NNS
cord-001835-0s7ok4uw	3540	21	-essentially	-essentially	RB
cord-001835-0s7ok4uw	3540	22	after	after	IN
cord-001835-0s7ok4uw	3540	23	every	every	DT
cord-001835-0s7ok4uw	3540	24	repeat	repeat	NN
cord-001835-0s7ok4uw	3540	25	but	but	CC
cord-001835-0s7ok4uw	3540	26	also	also	RB
cord-001835-0s7ok4uw	3540	27	within	within	IN
cord-001835-0s7ok4uw	3540	28	repeats	repeat	VBZ
cord-001835-0s7ok4uw	3540	29	.	.	.
cord-001835-0s7ok4uw	3541	1	The	the	DT
cord-001835-0s7ok4uw	3541	2	fragments	fragment	NNS
cord-001835-0s7ok4uw	3541	3	display	display	VBP
cord-001835-0s7ok4uw	3541	4	variable	variable	JJ
cord-001835-0s7ok4uw	3541	5	affinities	affinity	NNS
cord-001835-0s7ok4uw	3541	6	towards	towards	IN
cord-001835-0s7ok4uw	3541	7	each	each	DT
cord-001835-0s7ok4uw	3541	8	other	other	JJ
cord-001835-0s7ok4uw	3541	9	,	,	,
cord-001835-0s7ok4uw	3541	10	depending	depend	VBG
cord-001835-0s7ok4uw	3541	11	on	on	IN
cord-001835-0s7ok4uw	3541	12	the	the	DT
cord-001835-0s7ok4uw	3541	13	split	split	NN
cord-001835-0s7ok4uw	3541	14	site	site	NN
cord-001835-0s7ok4uw	3541	15	.	.	.
cord-001835-0s7ok4uw	3542	1	The	the	DT
cord-001835-0s7ok4uw	3542	2	low	low	JJ
cord-001835-0s7ok4uw	3542	3	affinity	affinity	NN
cord-001835-0s7ok4uw	3542	4	of	of	IN
cord-001835-0s7ok4uw	3542	5	some	some	DT
cord-001835-0s7ok4uw	3542	6	complementary	complementary	JJ
cord-001835-0s7ok4uw	3542	7	pairs	pair	NNS
cord-001835-0s7ok4uw	3542	8	can	can	MD
cord-001835-0s7ok4uw	3542	9	be	be	VB
cord-001835-0s7ok4uw	3542	10	dramatically	dramatically	RB
cord-001835-0s7ok4uw	3542	11	increased	increase	VBN
cord-001835-0s7ok4uw	3542	12	upon	upon	IN
cord-001835-0s7ok4uw	3542	13	addition	addition	NN
cord-001835-0s7ok4uw	3542	14	of	of	IN
cord-001835-0s7ok4uw	3542	15	peptide	peptide	NN
cord-001835-0s7ok4uw	3542	16	ligands	ligand	NNS
cord-001835-0s7ok4uw	3542	17	.	.	.
cord-001835-0s7ok4uw	3543	1	While	while	IN
cord-001835-0s7ok4uw	3543	2	a	a	DT
cord-001835-0s7ok4uw	3543	3	number	number	NN
cord-001835-0s7ok4uw	3543	4	of	of	IN
cord-001835-0s7ok4uw	3543	5	proteins	protein	NNS
cord-001835-0s7ok4uw	3543	6	are	be	VBP
cord-001835-0s7ok4uw	3543	7	known	know	VBN
cord-001835-0s7ok4uw	3543	8	that	that	WDT
cord-001835-0s7ok4uw	3543	9	can	can	MD
cord-001835-0s7ok4uw	3543	10	be	be	VB
cord-001835-0s7ok4uw	3543	11	reconstituted	reconstitute	VBN
cord-001835-0s7ok4uw	3543	12	from	from	IN
cord-001835-0s7ok4uw	3543	13	fragments	fragment	NNS
cord-001835-0s7ok4uw	3543	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	3543	15	believe	believe	VBP
cord-001835-0s7ok4uw	3543	16	that	that	IN
cord-001835-0s7ok4uw	3543	17	the	the	DT
cord-001835-0s7ok4uw	3543	18	fact	fact	NN
cord-001835-0s7ok4uw	3543	19	that	that	IN
cord-001835-0s7ok4uw	3543	20	Armadillo	Armadillo	NNP
cord-001835-0s7ok4uw	3543	21	repeat	repeat	NN
cord-001835-0s7ok4uw	3543	22	proteins	protein	NNS
cord-001835-0s7ok4uw	3543	23	can	can	MD
cord-001835-0s7ok4uw	3543	24	be	be	VB
cord-001835-0s7ok4uw	3543	25	reconstituted	reconstitute	VBN
cord-001835-0s7ok4uw	3543	26	from	from	IN
cord-001835-0s7ok4uw	3543	27	various	various	JJ
cord-001835-0s7ok4uw	3543	28	complementary	complementary	JJ
cord-001835-0s7ok4uw	3543	29	fragments	fragment	NNS
cord-001835-0s7ok4uw	3543	30	is	be	VBZ
cord-001835-0s7ok4uw	3543	31	novel	novel	JJ
cord-001835-0s7ok4uw	3543	32	and	and	CC
cord-001835-0s7ok4uw	3543	33	opens	open	VBZ
cord-001835-0s7ok4uw	3543	34	new	new	JJ
cord-001835-0s7ok4uw	3543	35	interesting	interesting	JJ
cord-001835-0s7ok4uw	3543	36	perspectives	perspective	NNS
cord-001835-0s7ok4uw	3543	37	and	and	CC
cord-001835-0s7ok4uw	3543	38	applications	application	NNS
cord-001835-0s7ok4uw	3543	39	in	in	IN
cord-001835-0s7ok4uw	3543	40	biochemistry	biochemistry	NN
cord-001835-0s7ok4uw	3543	41	.	.	.
cord-001835-0s7ok4uw	3544	1	A	a	DT
cord-001835-0s7ok4uw	3544	2	reliable	reliable	JJ
cord-001835-0s7ok4uw	3544	3	method	method	NN
cord-001835-0s7ok4uw	3544	4	for	for	IN
cord-001835-0s7ok4uw	3544	5	generating	generate	VBG
cord-001835-0s7ok4uw	3544	6	optically	optically	RB
cord-001835-0s7ok4uw	3544	7	controllable	controllable	JJ
cord-001835-0s7ok4uw	3544	8	proteins	protein	NNS
cord-001835-0s7ok4uw	3544	9	would	would	MD
cord-001835-0s7ok4uw	3544	10	enable	enable	VB
cord-001835-0s7ok4uw	3544	11	researchers	researcher	NNS
cord-001835-0s7ok4uw	3544	12	to	to	TO
cord-001835-0s7ok4uw	3544	13	interrogate	interrogate	VB
cord-001835-0s7ok4uw	3544	14	protein	protein	NN
cord-001835-0s7ok4uw	3544	15	functions	function	NNS
cord-001835-0s7ok4uw	3544	16	with	with	IN
cord-001835-0s7ok4uw	3544	17	high	high	JJ
cord-001835-0s7ok4uw	3544	18	spatiotemporal	spatiotemporal	JJ
cord-001835-0s7ok4uw	3544	19	specificity	specificity	NN
cord-001835-0s7ok4uw	3544	20	.	.	.
cord-001835-0s7ok4uw	3545	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3545	2	recently	recently	RB
cord-001835-0s7ok4uw	3545	3	engineered	engineer	VBD
cord-001835-0s7ok4uw	3545	4	a	a	DT
cord-001835-0s7ok4uw	3545	5	tetrameric	tetrameric	JJ
cord-001835-0s7ok4uw	3545	6	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	3545	7	protein	protein	NN
cord-001835-0s7ok4uw	3545	8	,	,	,
cord-001835-0s7ok4uw	3545	9	Dronpa145N	dronpa145n	ADD
cord-001835-0s7ok4uw	3545	10	,	,	,
cord-001835-0s7ok4uw	3545	11	that	that	WDT
cord-001835-0s7ok4uw	3545	12	undergoes	undergo	VBZ
cord-001835-0s7ok4uw	3545	13	light	light	NN
cord-001835-0s7ok4uw	3545	14	-	-	HYPH
cord-001835-0s7ok4uw	3545	15	induced	induce	VBN
cord-001835-0s7ok4uw	3545	16	monomerization	monomerization	NN
cord-001835-0s7ok4uw	3545	17	,	,	,
cord-001835-0s7ok4uw	3545	18	then	then	RB
cord-001835-0s7ok4uw	3545	19	developed	develop	VBD
cord-001835-0s7ok4uw	3545	20	a	a	DT
cord-001835-0s7ok4uw	3545	21	general	general	JJ
cord-001835-0s7ok4uw	3545	22	architecture	architecture	NN
cord-001835-0s7ok4uw	3545	23	for	for	IN
cord-001835-0s7ok4uw	3545	24	lightinducible	lightinducible	JJ
cord-001835-0s7ok4uw	3545	25	proteins	protein	NNS
cord-001835-0s7ok4uw	3545	26	based	base	VBN
cord-001835-0s7ok4uw	3545	27	on	on	IN
cord-001835-0s7ok4uw	3545	28	this	this	DT
cord-001835-0s7ok4uw	3545	29	light	light	NN
cord-001835-0s7ok4uw	3545	30	-	-	HYPH
cord-001835-0s7ok4uw	3545	31	induced	induce	VBN
cord-001835-0s7ok4uw	3545	32	transition	transition	NN
cord-001835-0s7ok4uw	3545	33	.	.	.
cord-001835-0s7ok4uw	3546	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3546	2	created	create	VBD
cord-001835-0s7ok4uw	3546	3	proteins	protein	NNS
cord-001835-0s7ok4uw	3546	4	whose	whose	WP$
cord-001835-0s7ok4uw	3546	5	active	active	JJ
cord-001835-0s7ok4uw	3546	6	sites	site	NNS
cord-001835-0s7ok4uw	3546	7	were	be	VBD
cord-001835-0s7ok4uw	3546	8	blocked	block	VBN
cord-001835-0s7ok4uw	3546	9	by	by	IN
cord-001835-0s7ok4uw	3546	10	fused	fuse	VBN
cord-001835-0s7ok4uw	3546	11	Dronpa145N	dronpa145n	CD
cord-001835-0s7ok4uw	3546	12	domains	domain	NNS
cord-001835-0s7ok4uw	3546	13	in	in	IN
cord-001835-0s7ok4uw	3546	14	the	the	DT
cord-001835-0s7ok4uw	3546	15	dark	dark	NN
cord-001835-0s7ok4uw	3546	16	,	,	,
cord-001835-0s7ok4uw	3546	17	but	but	CC
cord-001835-0s7ok4uw	3546	18	would	would	MD
cord-001835-0s7ok4uw	3546	19	become	become	VB
cord-001835-0s7ok4uw	3546	20	unblocked	unblock	VBN
cord-001835-0s7ok4uw	3546	21	by	by	IN
cord-001835-0s7ok4uw	3546	22	light	light	NN
cord-001835-0s7ok4uw	3546	23	.	.	.
cord-001835-0s7ok4uw	3547	1	Here	here	RB
cord-001835-0s7ok4uw	3547	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3547	3	present	present	VBP
cord-001835-0s7ok4uw	3547	4	further	further	RB
cord-001835-0s7ok4uw	3547	5	two	two	CD
cord-001835-0s7ok4uw	3547	6	extensions	extension	NNS
cord-001835-0s7ok4uw	3547	7	to	to	IN
cord-001835-0s7ok4uw	3547	8	this	this	DT
cord-001835-0s7ok4uw	3547	9	concept	concept	NN
cord-001835-0s7ok4uw	3547	10	that	that	IN
cord-001835-0s7ok4uw	3547	11	together	together	RB
cord-001835-0s7ok4uw	3547	12	enabled	enable	VBD
cord-001835-0s7ok4uw	3547	13	the	the	DT
cord-001835-0s7ok4uw	3547	14	generalization	generalization	NN
cord-001835-0s7ok4uw	3547	15	of	of	IN
cord-001835-0s7ok4uw	3547	16	this	this	DT
cord-001835-0s7ok4uw	3547	17	method	method	NN
cord-001835-0s7ok4uw	3547	18	to	to	IN
cord-001835-0s7ok4uw	3547	19	additional	additional	JJ
cord-001835-0s7ok4uw	3547	20	classes	class	NNS
cord-001835-0s7ok4uw	3547	21	of	of	IN
cord-001835-0s7ok4uw	3547	22	proteins	protein	NNS
cord-001835-0s7ok4uw	3547	23	.	.	.
cord-001835-0s7ok4uw	3548	1	First	first	RB
cord-001835-0s7ok4uw	3548	2	,	,	,
cord-001835-0s7ok4uw	3548	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3548	4	engineered	engineer	VBD
cord-001835-0s7ok4uw	3548	5	a	a	DT
cord-001835-0s7ok4uw	3548	6	photodissociable	photodissociable	JJ
cord-001835-0s7ok4uw	3548	7	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	3548	8	Dronpa	Dronpa	NNP
cord-001835-0s7ok4uw	3548	9	(	(	-LRB-
cord-001835-0s7ok4uw	3548	10	pdDronpa	pdDronpa	NNP
cord-001835-0s7ok4uw	3548	11	)	)	-RRB-
cord-001835-0s7ok4uw	3548	12	with	with	IN
cord-001835-0s7ok4uw	3548	13	tunable	tunable	JJ
cord-001835-0s7ok4uw	3548	14	affinity	affinity	NN
cord-001835-0s7ok4uw	3548	15	,	,	,
cord-001835-0s7ok4uw	3548	16	faster	fast	JJR
cord-001835-0s7ok4uw	3548	17	photoswitching	photoswitche	VBG
cord-001835-0s7ok4uw	3548	18	speed	speed	NN
cord-001835-0s7ok4uw	3548	19	,	,	,
cord-001835-0s7ok4uw	3548	20	and	and	CC
cord-001835-0s7ok4uw	3548	21	decreased	decrease	VBD
cord-001835-0s7ok4uw	3548	22	level	level	NN
cord-001835-0s7ok4uw	3548	23	of	of	IN
cord-001835-0s7ok4uw	3548	24	protein	protein	NN
cord-001835-0s7ok4uw	3548	25	aggregation	aggregation	NN
cord-001835-0s7ok4uw	3548	26	,	,	,
cord-001835-0s7ok4uw	3548	27	enabling	enable	VBG
cord-001835-0s7ok4uw	3548	28	better	well	JJR
cord-001835-0s7ok4uw	3548	29	performance	performance	NN
cord-001835-0s7ok4uw	3548	30	of	of	IN
cord-001835-0s7ok4uw	3548	31	fusion	fusion	NN
cord-001835-0s7ok4uw	3548	32	proteins	protein	NNS
cord-001835-0s7ok4uw	3548	33	.	.	.
cord-001835-0s7ok4uw	3549	1	Second	second	RB
cord-001835-0s7ok4uw	3549	2	,	,	,
cord-001835-0s7ok4uw	3549	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3549	4	introduce	introduce	VBP
cord-001835-0s7ok4uw	3549	5	the	the	DT
cord-001835-0s7ok4uw	3549	6	concept	concept	NN
cord-001835-0s7ok4uw	3549	7	of	of	IN
cord-001835-0s7ok4uw	3549	8	caging	cage	VBG
cord-001835-0s7ok4uw	3549	9	a	a	DT
cord-001835-0s7ok4uw	3549	10	protein	protein	NN
cord-001835-0s7ok4uw	3549	11	active	active	JJ
cord-001835-0s7ok4uw	3549	12	site	site	NN
cord-001835-0s7ok4uw	3549	13	by	by	IN
cord-001835-0s7ok4uw	3549	14	insertion	insertion	NN
cord-001835-0s7ok4uw	3549	15	of	of	IN
cord-001835-0s7ok4uw	3549	16	Dronpa	Dronpa	NNP
cord-001835-0s7ok4uw	3549	17	domains	domain	NNS
cord-001835-0s7ok4uw	3549	18	into	into	IN
cord-001835-0s7ok4uw	3549	19	loops	loop	NNS
cord-001835-0s7ok4uw	3549	20	rather	rather	RB
cord-001835-0s7ok4uw	3549	21	than	than	IN
cord-001835-0s7ok4uw	3549	22	strictly	strictly	RB
cord-001835-0s7ok4uw	3549	23	at	at	IN
cord-001835-0s7ok4uw	3549	24	the	the	DT
cord-001835-0s7ok4uw	3549	25	protein	protein	NN
cord-001835-0s7ok4uw	3549	26	termini	termini	NNP
cord-001835-0s7ok4uw	3549	27	.	.	.
cord-001835-0s7ok4uw	3550	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3550	2	use	use	VBP
cord-001835-0s7ok4uw	3550	3	the	the	DT
cord-001835-0s7ok4uw	3550	4	pdDronpa	pdDronpa	NNP
cord-001835-0s7ok4uw	3550	5	system	system	NN
cord-001835-0s7ok4uw	3550	6	to	to	TO
cord-001835-0s7ok4uw	3550	7	impose	impose	VB
cord-001835-0s7ok4uw	3550	8	optical	optical	JJ
cord-001835-0s7ok4uw	3550	9	control	control	NN
cord-001835-0s7ok4uw	3550	10	on	on	IN
cord-001835-0s7ok4uw	3550	11	kinases	kinase	NNS
cord-001835-0s7ok4uw	3550	12	and	and	CC
cord-001835-0s7ok4uw	3550	13	the	the	DT
cord-001835-0s7ok4uw	3550	14	Cas9	Cas9	NNP
cord-001835-0s7ok4uw	3550	15	endonuclease	endonuclease	NN
cord-001835-0s7ok4uw	3550	16	.	.	.
cord-001835-0s7ok4uw	3551	1	The	the	DT
cord-001835-0s7ok4uw	3551	2	resulting	result	VBG
cord-001835-0s7ok4uw	3551	3	light	light	NN
cord-001835-0s7ok4uw	3551	4	-	-	HYPH
cord-001835-0s7ok4uw	3551	5	inducible	inducible	JJ
cord-001835-0s7ok4uw	3551	6	MEK1	MEK1	NNP
cord-001835-0s7ok4uw	3551	7	kinase	kinase	NN
cord-001835-0s7ok4uw	3551	8	,	,	,
cord-001835-0s7ok4uw	3551	9	Raf1	Raf1	NNP
cord-001835-0s7ok4uw	3551	10	kinase	kinase	NN
cord-001835-0s7ok4uw	3551	11	,	,	,
cord-001835-0s7ok4uw	3551	12	and	and	CC
cord-001835-0s7ok4uw	3551	13	Cas9	Cas9	NNP
cord-001835-0s7ok4uw	3551	14	endonuclease	endonuclease	NN
cord-001835-0s7ok4uw	3551	15	showed	show	VBD
cord-001835-0s7ok4uw	3551	16	high	high	JJ
cord-001835-0s7ok4uw	3551	17	caging	caging	NN
cord-001835-0s7ok4uw	3551	18	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3551	19	of	of	IN
cord-001835-0s7ok4uw	3551	20	protein	protein	NN
cord-001835-0s7ok4uw	3551	21	activities	activity	NNS
cord-001835-0s7ok4uw	3551	22	in	in	IN
cord-001835-0s7ok4uw	3551	23	the	the	DT
cord-001835-0s7ok4uw	3551	24	dark	dark	NN
cord-001835-0s7ok4uw	3551	25	,	,	,
cord-001835-0s7ok4uw	3551	26	and	and	CC
cord-001835-0s7ok4uw	3551	27	robust	robust	JJ
cord-001835-0s7ok4uw	3551	28	protein	protein	NN
cord-001835-0s7ok4uw	3551	29	activation	activation	NN
cord-001835-0s7ok4uw	3551	30	upon	upon	IN
cord-001835-0s7ok4uw	3551	31	light	light	JJ
cord-001835-0s7ok4uw	3551	32	illumination	illumination	NN
cord-001835-0s7ok4uw	3551	33	.	.	.
cord-001835-0s7ok4uw	3552	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3552	2	believe	believe	VBP
cord-001835-0s7ok4uw	3552	3	that	that	IN
cord-001835-0s7ok4uw	3552	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3552	5	efforts	effort	NNS
cord-001835-0s7ok4uw	3552	6	on	on	IN
cord-001835-0s7ok4uw	3552	7	further	further	RB
cord-001835-0s7ok4uw	3552	8	improving	improve	VBG
cord-001835-0s7ok4uw	3552	9	and	and	CC
cord-001835-0s7ok4uw	3552	10	generalizing	generalize	VBG
cord-001835-0s7ok4uw	3552	11	this	this	DT
cord-001835-0s7ok4uw	3552	12	method	method	NN
cord-001835-0s7ok4uw	3552	13	would	would	MD
cord-001835-0s7ok4uw	3552	14	bring	bring	VB
cord-001835-0s7ok4uw	3552	15	the	the	DT
cord-001835-0s7ok4uw	3552	16	power	power	NN
cord-001835-0s7ok4uw	3552	17	and	and	CC
cord-001835-0s7ok4uw	3552	18	benefits	benefit	NNS
cord-001835-0s7ok4uw	3552	19	of	of	IN
cord-001835-0s7ok4uw	3552	20	light	light	JJ
cord-001835-0s7ok4uw	3552	21	control	control	NN
cord-001835-0s7ok4uw	3552	22	to	to	IN
cord-001835-0s7ok4uw	3552	23	a	a	DT
cord-001835-0s7ok4uw	3552	24	broad	broad	JJ
cord-001835-0s7ok4uw	3552	25	community	community	NN
cord-001835-0s7ok4uw	3552	26	of	of	IN
cord-001835-0s7ok4uw	3552	27	biologists	biologist	NNS
cord-001835-0s7ok4uw	3552	28	.	.	.
cord-001835-0s7ok4uw	3553	1	Exploring	explore	VBG
cord-001835-0s7ok4uw	3553	2	the	the	DT
cord-001835-0s7ok4uw	3553	3	evolution	evolution	NN
cord-001835-0s7ok4uw	3553	4	of	of	IN
cord-001835-0s7ok4uw	3553	5	folds	fold	NNS
cord-001835-0s7ok4uw	3553	6	and	and	CC
cord-001835-0s7ok4uw	3553	7	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3553	8	application	application	NN
cord-001835-0s7ok4uw	3553	9	for	for	IN
cord-001835-0s7ok4uw	3553	10	the	the	DT
cord-001835-0s7ok4uw	3553	11	design	design	NN
cord-001835-0s7ok4uw	3553	12	of	of	IN
cord-001835-0s7ok4uw	3553	13	functional	functional	JJ
cord-001835-0s7ok4uw	3553	14	hybrid	hybrid	NN
cord-001835-0s7ok4uw	3553	15	proteins	protein	NNS
cord-001835-0s7ok4uw	3553	16	Saacnicteh	Saacnicteh	NNP
cord-001835-0s7ok4uw	3553	17	Toledo	Toledo	NNP
cord-001835-0s7ok4uw	3553	18	Patiño	Patiño	NNPS
cord-001835-0s7ok4uw	3553	19	1	1	CD
cord-001835-0s7ok4uw	3554	1	,	,	,
cord-001835-0s7ok4uw	3554	2	Birte	Birte	NNP
cord-001835-0s7ok4uw	3554	3	H€	h€	JJ
cord-001835-0s7ok4uw	3554	4	ocker	ocker	NNP
cord-001835-0s7ok4uw	3554	5	1	1	CD
cord-001835-0s7ok4uw	3554	6	1	1	CD
cord-001835-0s7ok4uw	3555	1	The	the	DT
cord-001835-0s7ok4uw	3555	2	structural	structural	JJ
cord-001835-0s7ok4uw	3555	3	diversity	diversity	NN
cord-001835-0s7ok4uw	3555	4	of	of	IN
cord-001835-0s7ok4uw	3555	5	proteins	protein	NNS
cord-001835-0s7ok4uw	3555	6	may	may	MD
cord-001835-0s7ok4uw	3555	7	appear	appear	VB
cord-001835-0s7ok4uw	3555	8	endless	endless	JJ
cord-001835-0s7ok4uw	3555	9	,	,	,
cord-001835-0s7ok4uw	3555	10	nevertheless	nevertheless	RB
cord-001835-0s7ok4uw	3555	11	even	even	RB
cord-001835-0s7ok4uw	3555	12	large	large	JJ
cord-001835-0s7ok4uw	3555	13	protein	protein	NN
cord-001835-0s7ok4uw	3555	14	complexes	complex	NNS
cord-001835-0s7ok4uw	3555	15	can	can	MD
cord-001835-0s7ok4uw	3555	16	be	be	VB
cord-001835-0s7ok4uw	3555	17	decomposed	decompose	VBN
cord-001835-0s7ok4uw	3555	18	into	into	IN
cord-001835-0s7ok4uw	3555	19	protein	protein	NN
cord-001835-0s7ok4uw	3555	20	domains	domain	NNS
cord-001835-0s7ok4uw	3555	21	and	and	CC
cord-001835-0s7ok4uw	3555	22	smaller	small	JJR
cord-001835-0s7ok4uw	3555	23	sub	sub	NN
cord-001835-0s7ok4uw	3555	24	-	-	JJ
cord-001835-0s7ok4uw	3555	25	domain	domain	NN
cord-001835-0s7ok4uw	3555	26	sized	sized	JJ
cord-001835-0s7ok4uw	3555	27	fragments	fragment	NNS
cord-001835-0s7ok4uw	3555	28	.	.	.
cord-001835-0s7ok4uw	3556	1	Only	only	RB
cord-001835-0s7ok4uw	3556	2	recently	recently	RB
cord-001835-0s7ok4uw	3556	3	,	,	,
cord-001835-0s7ok4uw	3556	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3556	5	could	could	MD
cord-001835-0s7ok4uw	3556	6	identify	identify	VB
cord-001835-0s7ok4uw	3556	7	such	such	JJ
cord-001835-0s7ok4uw	3556	8	fragments	fragment	NNS
cord-001835-0s7ok4uw	3556	9	employing	employ	VBG
cord-001835-0s7ok4uw	3556	10	sequence	sequence	NN
cord-001835-0s7ok4uw	3556	11	-	-	HYPH
cord-001835-0s7ok4uw	3556	12	based	base	VBN
cord-001835-0s7ok4uw	3556	13	comparisons	comparison	NNS
cord-001835-0s7ok4uw	3556	14	of	of	IN
cord-001835-0s7ok4uw	3556	15	different	different	JJ
cord-001835-0s7ok4uw	3556	16	folds	fold	NNS
cord-001835-0s7ok4uw	3556	17	,	,	,
cord-001835-0s7ok4uw	3556	18	as	as	IN
cord-001835-0s7ok4uw	3556	19	the	the	DT
cord-001835-0s7ok4uw	3556	20	TIM	TIM	NNP
cord-001835-0s7ok4uw	3556	21	-	-	HYPH
cord-001835-0s7ok4uw	3556	22	barrel	barrel	NN
cord-001835-0s7ok4uw	3556	23	and	and	CC
cord-001835-0s7ok4uw	3556	24	the	the	DT
cord-001835-0s7ok4uw	3556	25	flavodoxin	flavodoxin	NN
cord-001835-0s7ok4uw	3556	26	-	-	HYPH
cord-001835-0s7ok4uw	3556	27	like	like	UH
cord-001835-0s7ok4uw	3556	28	fold	fold	NN
cord-001835-0s7ok4uw	3557	1	(	(	-LRB-
cord-001835-0s7ok4uw	3557	2	Farias	Farias	NNP
cord-001835-0s7ok4uw	3557	3	-	-	HYPH
cord-001835-0s7ok4uw	3557	4	Rico	Rico	NNP
cord-001835-0s7ok4uw	3557	5	et	et	NNP
cord-001835-0s7ok4uw	3557	6	al	al	NNP
cord-001835-0s7ok4uw	3557	7	.	.	NNP
cord-001835-0s7ok4uw	3557	8	,	,	,
cord-001835-0s7ok4uw	3557	9	2014	2014	CD
cord-001835-0s7ok4uw	3557	10	)	)	-RRB-
cord-001835-0s7ok4uw	3557	11	.	.	.
cord-001835-0s7ok4uw	3558	1	As	as	IN
cord-001835-0s7ok4uw	3558	2	an	an	DT
cord-001835-0s7ok4uw	3558	3	extension	extension	NN
cord-001835-0s7ok4uw	3558	4	of	of	IN
cord-001835-0s7ok4uw	3558	5	this	this	DT
cord-001835-0s7ok4uw	3558	6	work	work	NN
cord-001835-0s7ok4uw	3558	7	,	,	,
cord-001835-0s7ok4uw	3558	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	3558	9	compared	compare	VBD
cord-001835-0s7ok4uw	3558	10	all	all	PDT
cord-001835-0s7ok4uw	3558	11	a	a	DT
cord-001835-0s7ok4uw	3558	12	/	/	SYM
cord-001835-0s7ok4uw	3558	13	b	b	NN
cord-001835-0s7ok4uw	3558	14	proteins	protein	NNS
cord-001835-0s7ok4uw	3558	15	and	and	CC
cord-001835-0s7ok4uw	3558	16	identified	identify	VBD
cord-001835-0s7ok4uw	3558	17	several	several	JJ
cord-001835-0s7ok4uw	3558	18	fragments	fragment	NNS
cord-001835-0s7ok4uw	3558	19	shared	share	VBN
cord-001835-0s7ok4uw	3558	20	by	by	IN
cord-001835-0s7ok4uw	3558	21	different	different	JJ
cord-001835-0s7ok4uw	3558	22	folds	fold	NNS
cord-001835-0s7ok4uw	3558	23	illustrating	illustrate	VBG
cord-001835-0s7ok4uw	3558	24	how	how	WRB
cord-001835-0s7ok4uw	3558	25	nature	nature	NN
cord-001835-0s7ok4uw	3558	26	may	may	MD
cord-001835-0s7ok4uw	3558	27	have	have	VB
cord-001835-0s7ok4uw	3558	28	achieved	achieve	VBN
cord-001835-0s7ok4uw	3558	29	structural	structural	JJ
cord-001835-0s7ok4uw	3558	30	and	and	CC
cord-001835-0s7ok4uw	3558	31	functional	functional	JJ
cord-001835-0s7ok4uw	3558	32	diversity	diversity	NN
cord-001835-0s7ok4uw	3558	33	from	from	IN
cord-001835-0s7ok4uw	3558	34	a	a	DT
cord-001835-0s7ok4uw	3558	35	reduced	reduce	VBN
cord-001835-0s7ok4uw	3558	36	set	set	NN
cord-001835-0s7ok4uw	3558	37	of	of	IN
cord-001835-0s7ok4uw	3558	38	building	building	NN
cord-001835-0s7ok4uw	3558	39	blocks	block	NNS
cord-001835-0s7ok4uw	3558	40	.	.	.
cord-001835-0s7ok4uw	3559	1	Inspired	inspire	VBN
cord-001835-0s7ok4uw	3559	2	by	by	IN
cord-001835-0s7ok4uw	3559	3	this	this	DT
cord-001835-0s7ok4uw	3559	4	combinatorial	combinatorial	JJ
cord-001835-0s7ok4uw	3559	5	concept	concept	NN
cord-001835-0s7ok4uw	3559	6	,	,	,
cord-001835-0s7ok4uw	3559	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	3559	8	searched	search	VBD
cord-001835-0s7ok4uw	3559	9	for	for	IN
cord-001835-0s7ok4uw	3559	10	homologous	homologous	JJ
cord-001835-0s7ok4uw	3559	11	fragments	fragment	NNS
cord-001835-0s7ok4uw	3559	12	bearing	bear	VBG
cord-001835-0s7ok4uw	3559	13	active	active	JJ
cord-001835-0s7ok4uw	3559	14	sites	site	NNS
cord-001835-0s7ok4uw	3559	15	to	to	TO
cord-001835-0s7ok4uw	3559	16	engineer	engineer	VB
cord-001835-0s7ok4uw	3559	17	a	a	DT
cord-001835-0s7ok4uw	3559	18	functional	functional	JJ
cord-001835-0s7ok4uw	3559	19	fold	fold	NN
cord-001835-0s7ok4uw	3559	20	-	-	HYPH
cord-001835-0s7ok4uw	3559	21	chimera	chimera	NN
cord-001835-0s7ok4uw	3559	22	.	.	.
cord-001835-0s7ok4uw	3560	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3560	2	extracted	extract	VBD
cord-001835-0s7ok4uw	3560	3	the	the	DT
cord-001835-0s7ok4uw	3560	4	vitamin	vitamin	NN
cord-001835-0s7ok4uw	3560	5	-	-	HYPH
cord-001835-0s7ok4uw	3560	6	B12	b12	NN
cord-001835-0s7ok4uw	3560	7	binding	binding	NN
cord-001835-0s7ok4uw	3560	8	part	part	NN
cord-001835-0s7ok4uw	3560	9	from	from	IN
cord-001835-0s7ok4uw	3560	10	methylmalonyl	methylmalonyl	NNP
cord-001835-0s7ok4uw	3560	11	CoA	CoA	NNP
cord-001835-0s7ok4uw	3560	12	mutase	mutase	NNP
cord-001835-0s7ok4uw	3560	13	,	,	,
cord-001835-0s7ok4uw	3560	14	which	which	WDT
cord-001835-0s7ok4uw	3560	15	belongs	belong	VBZ
cord-001835-0s7ok4uw	3560	16	to	to	IN
cord-001835-0s7ok4uw	3560	17	the	the	DT
cord-001835-0s7ok4uw	3560	18	flavodoxin	flavodoxin	NN
cord-001835-0s7ok4uw	3560	19	-	-	HYPH
cord-001835-0s7ok4uw	3560	20	like	like	IN
cord-001835-0s7ok4uw	3560	21	fold	fold	JJ
cord-001835-0s7ok4uw	3560	22	(	(	-LRB-
cord-001835-0s7ok4uw	3560	23	FL	FL	NNP
cord-001835-0s7ok4uw	3560	24	)	)	-RRB-
cord-001835-0s7ok4uw	3560	25	and	and	CC
cord-001835-0s7ok4uw	3560	26	used	use	VBD
cord-001835-0s7ok4uw	3560	27	it	-PRON-	PRP
cord-001835-0s7ok4uw	3560	28	to	to	TO
cord-001835-0s7ok4uw	3560	29	replace	replace	VB
cord-001835-0s7ok4uw	3560	30	the	the	DT
cord-001835-0s7ok4uw	3560	31	corresponding	corresponding	JJ
cord-001835-0s7ok4uw	3560	32	fragment	fragment	NN
cord-001835-0s7ok4uw	3560	33	in	in	IN
cord-001835-0s7ok4uw	3560	34	uroporphyrinogen	uroporphyrinogen	NNP
cord-001835-0s7ok4uw	3560	35	III	III	NNP
cord-001835-0s7ok4uw	3560	36	synthase	synthase	NN
cord-001835-0s7ok4uw	3560	37	,	,	,
cord-001835-0s7ok4uw	3560	38	which	which	WDT
cord-001835-0s7ok4uw	3560	39	belongs	belong	VBZ
cord-001835-0s7ok4uw	3560	40	to	to	IN
cord-001835-0s7ok4uw	3560	41	the	the	DT
cord-001835-0s7ok4uw	3560	42	hemD	hemD	NNPS
cord-001835-0s7ok4uw	3560	43	-	-	HYPH
cord-001835-0s7ok4uw	3560	44	like	like	IN
cord-001835-0s7ok4uw	3560	45	fold	fold	JJ
cord-001835-0s7ok4uw	3560	46	(	(	-LRB-
cord-001835-0s7ok4uw	3560	47	HDL	HDL	NNP
cord-001835-0s7ok4uw	3560	48	)	)	-RRB-
cord-001835-0s7ok4uw	3560	49	.	.	.
cord-001835-0s7ok4uw	3561	1	The	the	DT
cord-001835-0s7ok4uw	3561	2	new	new	JJ
cord-001835-0s7ok4uw	3561	3	hybrid	hybrid	NN
cord-001835-0s7ok4uw	3561	4	resulted	result	VBD
cord-001835-0s7ok4uw	3561	5	in	in	IN
cord-001835-0s7ok4uw	3561	6	a	a	DT
cord-001835-0s7ok4uw	3561	7	stable	stable	JJ
cord-001835-0s7ok4uw	3561	8	and	and	CC
cord-001835-0s7ok4uw	3561	9	well	well	RB
cord-001835-0s7ok4uw	3561	10	-	-	HYPH
cord-001835-0s7ok4uw	3561	11	folded	fold	VBN
cord-001835-0s7ok4uw	3561	12	protein	protein	NN
cord-001835-0s7ok4uw	3561	13	whose	whose	WP$
cord-001835-0s7ok4uw	3561	14	structure	structure	NN
cord-001835-0s7ok4uw	3561	15	was	be	VBD
cord-001835-0s7ok4uw	3561	16	determined	determine	VBN
cord-001835-0s7ok4uw	3561	17	by	by	IN
cord-001835-0s7ok4uw	3561	18	X	x	NN
cord-001835-0s7ok4uw	3561	19	-	-	NN
cord-001835-0s7ok4uw	3561	20	ray	ray	NN
cord-001835-0s7ok4uw	3561	21	crystallography	crystallography	NN
cord-001835-0s7ok4uw	3561	22	.	.	.
cord-001835-0s7ok4uw	3562	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	3562	2	,	,	,
cord-001835-0s7ok4uw	3562	3	cobalamin	cobalamin	NN
cord-001835-0s7ok4uw	3562	4	-	-	HYPH
cord-001835-0s7ok4uw	3562	5	binding	bind	VBG
cord-001835-0s7ok4uw	3562	6	function	function	NN
cord-001835-0s7ok4uw	3562	7	was	be	VBD
cord-001835-0s7ok4uw	3562	8	successfully	successfully	RB
cord-001835-0s7ok4uw	3562	9	transferred	transfer	VBN
cord-001835-0s7ok4uw	3562	10	to	to	IN
cord-001835-0s7ok4uw	3562	11	the	the	DT
cord-001835-0s7ok4uw	3562	12	new	new	JJ
cord-001835-0s7ok4uw	3562	13	protein	protein	NN
cord-001835-0s7ok4uw	3562	14	from	from	IN
cord-001835-0s7ok4uw	3562	15	the	the	DT
cord-001835-0s7ok4uw	3562	16	FL	FL	NNP
cord-001835-0s7ok4uw	3562	17	parent	parent	NN
cord-001835-0s7ok4uw	3562	18	,	,	,
cord-001835-0s7ok4uw	3562	19	which	which	WDT
cord-001835-0s7ok4uw	3562	20	shows	show	VBZ
cord-001835-0s7ok4uw	3562	21	the	the	DT
cord-001835-0s7ok4uw	3562	22	advantage	advantage	NN
cord-001835-0s7ok4uw	3562	23	of	of	IN
cord-001835-0s7ok4uw	3562	24	using	use	VBG
cord-001835-0s7ok4uw	3562	25	this	this	DT
cord-001835-0s7ok4uw	3562	26	approach	approach	NN
cord-001835-0s7ok4uw	3562	27	for	for	IN
cord-001835-0s7ok4uw	3562	28	the	the	DT
cord-001835-0s7ok4uw	3562	29	design	design	NN
cord-001835-0s7ok4uw	3562	30	of	of	IN
cord-001835-0s7ok4uw	3562	31	new	new	JJ
cord-001835-0s7ok4uw	3562	32	functional	functional	JJ
cord-001835-0s7ok4uw	3562	33	proteins	protein	NNS
cord-001835-0s7ok4uw	3562	34	.	.	.
cord-001835-0s7ok4uw	3563	1	In	in	IN
cord-001835-0s7ok4uw	3563	2	addition	addition	NN
cord-001835-0s7ok4uw	3563	3	,	,	,
cord-001835-0s7ok4uw	3563	4	profile	profile	NN
cord-001835-0s7ok4uw	3563	5	alignments	alignment	NNS
cord-001835-0s7ok4uw	3563	6	revealed	reveal	VBD
cord-001835-0s7ok4uw	3563	7	sequence	sequence	NN
cord-001835-0s7ok4uw	3563	8	and	and	CC
cord-001835-0s7ok4uw	3563	9	structural	structural	JJ
cord-001835-0s7ok4uw	3563	10	evidence	evidence	NN
cord-001835-0s7ok4uw	3563	11	that	that	WDT
cord-001835-0s7ok4uw	3563	12	suggested	suggest	VBD
cord-001835-0s7ok4uw	3563	13	an	an	DT
cord-001835-0s7ok4uw	3563	14	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	3563	15	path	path	NN
cord-001835-0s7ok4uw	3563	16	for	for	IN
cord-001835-0s7ok4uw	3563	17	HDL	HDL	NNP
cord-001835-0s7ok4uw	3563	18	from	from	IN
cord-001835-0s7ok4uw	3563	19	FL	FL	NNP
cord-001835-0s7ok4uw	3563	20	by	by	IN
cord-001835-0s7ok4uw	3563	21	gene	gene	NN
cord-001835-0s7ok4uw	3563	22	duplication	duplication	NN
cord-001835-0s7ok4uw	3563	23	.	.	.
cord-001835-0s7ok4uw	3564	1	To	to	TO
cord-001835-0s7ok4uw	3564	2	test	test	VB
cord-001835-0s7ok4uw	3564	3	this	this	DT
cord-001835-0s7ok4uw	3564	4	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	3564	5	,	,	,
cord-001835-0s7ok4uw	3564	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	3564	7	expressed	express	VBD
cord-001835-0s7ok4uw	3564	8	a	a	DT
cord-001835-0s7ok4uw	3564	9	modified	modify	VBN
cord-001835-0s7ok4uw	3564	10	C	c	NN
cord-001835-0s7ok4uw	3564	11	-	-	HYPH
cord-001835-0s7ok4uw	3564	12	terminal	terminal	NN
cord-001835-0s7ok4uw	3564	13	half	half	NN
cord-001835-0s7ok4uw	3564	14	of	of	IN
cord-001835-0s7ok4uw	3564	15	uroporphyrinogen	uroporphyrinogen	NNP
cord-001835-0s7ok4uw	3564	16	III	III	NNP
cord-001835-0s7ok4uw	3564	17	synthase	synthase	NNP
cord-001835-0s7ok4uw	3564	18	and	and	CC
cord-001835-0s7ok4uw	3564	19	solved	solve	VBD
cord-001835-0s7ok4uw	3564	20	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3564	21	structure	structure	NN
cord-001835-0s7ok4uw	3564	22	by	by	IN
cord-001835-0s7ok4uw	3564	23	NMR	NMR	NNP
cord-001835-0s7ok4uw	3564	24	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	3564	25	,	,	,
cord-001835-0s7ok4uw	3564	26	thereby	thereby	RB
cord-001835-0s7ok4uw	3564	27	confirming	confirm	VBG
cord-001835-0s7ok4uw	3564	28	the	the	DT
cord-001835-0s7ok4uw	3564	29	predicted	predict	VBN
cord-001835-0s7ok4uw	3564	30	FL	FL	NNP
cord-001835-0s7ok4uw	3564	31	architecture	architecture	NN
cord-001835-0s7ok4uw	3564	32	.	.	.
cord-001835-0s7ok4uw	3565	1	Altogether	altogether	RB
cord-001835-0s7ok4uw	3565	2	,	,	,
cord-001835-0s7ok4uw	3565	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3565	4	approach	approach	NN
cord-001835-0s7ok4uw	3565	5	facilitates	facilitate	VBZ
cord-001835-0s7ok4uw	3565	6	the	the	DT
cord-001835-0s7ok4uw	3565	7	detection	detection	NN
cord-001835-0s7ok4uw	3565	8	of	of	IN
cord-001835-0s7ok4uw	3565	9	common	common	JJ
cord-001835-0s7ok4uw	3565	10	ancestry	ancestry	NN
cord-001835-0s7ok4uw	3565	11	among	among	IN
cord-001835-0s7ok4uw	3565	12	different	different	JJ
cord-001835-0s7ok4uw	3565	13	folds	fold	NNS
cord-001835-0s7ok4uw	3565	14	contributing	contribute	VBG
cord-001835-0s7ok4uw	3565	15	to	to	IN
cord-001835-0s7ok4uw	3565	16	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3565	17	understanding	understanding	NN
cord-001835-0s7ok4uw	3565	18	of	of	IN
cord-001835-0s7ok4uw	3565	19	protein	protein	NN
cord-001835-0s7ok4uw	3565	20	development	development	NN
cord-001835-0s7ok4uw	3565	21	.	.	.
cord-001835-0s7ok4uw	3566	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	3566	2	,	,	,
cord-001835-0s7ok4uw	3566	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3566	4	results	result	NNS
cord-001835-0s7ok4uw	3566	5	show	show	VBP
cord-001835-0s7ok4uw	3566	6	how	how	WRB
cord-001835-0s7ok4uw	3566	7	new	new	JJ
cord-001835-0s7ok4uw	3566	8	complex	complex	JJ
cord-001835-0s7ok4uw	3566	9	proteins	protein	NNS
cord-001835-0s7ok4uw	3566	10	can	can	MD
cord-001835-0s7ok4uw	3566	11	be	be	VB
cord-001835-0s7ok4uw	3566	12	designed	design	VBN
cord-001835-0s7ok4uw	3566	13	using	use	VBG
cord-001835-0s7ok4uw	3566	14	fragments	fragment	NNS
cord-001835-0s7ok4uw	3566	15	of	of	IN
cord-001835-0s7ok4uw	3566	16	existing	exist	VBG
cord-001835-0s7ok4uw	3566	17	proteins	protein	NNS
cord-001835-0s7ok4uw	3566	18	that	that	WDT
cord-001835-0s7ok4uw	3566	19	serve	serve	VBP
cord-001835-0s7ok4uw	3566	20	as	as	IN
cord-001835-0s7ok4uw	3566	21	building	building	NN
cord-001835-0s7ok4uw	3566	22	blocks	block	NNS
cord-001835-0s7ok4uw	3566	23	in	in	IN
cord-001835-0s7ok4uw	3566	24	a	a	DT
cord-001835-0s7ok4uw	3566	25	Lego	Lego	NNP
cord-001835-0s7ok4uw	3566	26	-	-	HYPH
cord-001835-0s7ok4uw	3566	27	like	like	JJ
cord-001835-0s7ok4uw	3566	28	manner	manner	NN
cord-001835-0s7ok4uw	3566	29	.	.	.
cord-001835-0s7ok4uw	3567	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3567	2	believe	believe	VBP
cord-001835-0s7ok4uw	3567	3	that	that	IN
cord-001835-0s7ok4uw	3567	4	combining	combine	VBG
cord-001835-0s7ok4uw	3567	5	fragments	fragment	NNS
cord-001835-0s7ok4uw	3567	6	containing	contain	VBG
cord-001835-0s7ok4uw	3567	7	existing	exist	VBG
cord-001835-0s7ok4uw	3567	8	properties	property	NNS
cord-001835-0s7ok4uw	3567	9	will	will	MD
cord-001835-0s7ok4uw	3567	10	provide	provide	VB
cord-001835-0s7ok4uw	3567	11	a	a	DT
cord-001835-0s7ok4uw	3567	12	successful	successful	JJ
cord-001835-0s7ok4uw	3567	13	method	method	NN
cord-001835-0s7ok4uw	3567	14	for	for	IN
cord-001835-0s7ok4uw	3567	15	the	the	DT
cord-001835-0s7ok4uw	3567	16	design	design	NN
cord-001835-0s7ok4uw	3567	17	of	of	IN
cord-001835-0s7ok4uw	3567	18	novel	novel	JJ
cord-001835-0s7ok4uw	3567	19	functionalities	functionality	NNS
cord-001835-0s7ok4uw	3567	20	in	in	IN
cord-001835-0s7ok4uw	3567	21	the	the	DT
cord-001835-0s7ok4uw	3567	22	future	future	NN
cord-001835-0s7ok4uw	3567	23	.	.	.
cord-001835-0s7ok4uw	3568	1	[	[	-LRB-
cord-001835-0s7ok4uw	3568	2	2	2	CD
cord-001835-0s7ok4uw	3568	3	]	]	-RRB-
cord-001835-0s7ok4uw	3568	4	.	.	.
cord-001835-0s7ok4uw	3569	1	The	the	DT
cord-001835-0s7ok4uw	3569	2	active	active	JJ
cord-001835-0s7ok4uw	3569	3	site	site	NN
cord-001835-0s7ok4uw	3569	4	cysteine	cysteine	NN
cord-001835-0s7ok4uw	3569	5	plays	play	VBZ
cord-001835-0s7ok4uw	3569	6	a	a	DT
cord-001835-0s7ok4uw	3569	7	key	key	JJ
cord-001835-0s7ok4uw	3569	8	role	role	NN
cord-001835-0s7ok4uw	3569	9	in	in	IN
cord-001835-0s7ok4uw	3569	10	the	the	DT
cord-001835-0s7ok4uw	3569	11	reaction	reaction	NN
cord-001835-0s7ok4uw	3569	12	mechanism	mechanism	NN
cord-001835-0s7ok4uw	3569	13	and	and	CC
cord-001835-0s7ok4uw	3569	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	3569	15	investigated	investigate	VBD
cord-001835-0s7ok4uw	3569	16	this	this	DT
cord-001835-0s7ok4uw	3569	17	residue	residue	NN
cord-001835-0s7ok4uw	3569	18	in	in	IN
cord-001835-0s7ok4uw	3569	19	more	more	JJR
cord-001835-0s7ok4uw	3569	20	detail	detail	NN
cord-001835-0s7ok4uw	3569	21	by	by	IN
cord-001835-0s7ok4uw	3569	22	exchanging	exchange	VBG
cord-001835-0s7ok4uw	3569	23	this	this	DT
cord-001835-0s7ok4uw	3569	24	moiety	moiety	NN
cord-001835-0s7ok4uw	3569	25	with	with	IN
cord-001835-0s7ok4uw	3569	26	selenocysteine	selenocysteine	NN
cord-001835-0s7ok4uw	3569	27	(	(	-LRB-
cord-001835-0s7ok4uw	3569	28	Sec	Sec	NNP
cord-001835-0s7ok4uw	3569	29	)	)	-RRB-
cord-001835-0s7ok4uw	3569	30	and	and	CC
cord-001835-0s7ok4uw	3569	31	homocysteine	homocysteine	NN
cord-001835-0s7ok4uw	3569	32	(	(	-LRB-
cord-001835-0s7ok4uw	3569	33	Hcy	Hcy	NNP
cord-001835-0s7ok4uw	3569	34	)	)	-RRB-
cord-001835-0s7ok4uw	3569	35	.	.	.
cord-001835-0s7ok4uw	3570	1	The	the	DT
cord-001835-0s7ok4uw	3570	2	sortase	sortase	NN
cord-001835-0s7ok4uw	3570	3	mutants	mutant	NNS
cord-001835-0s7ok4uw	3570	4	were	be	VBD
cord-001835-0s7ok4uw	3570	5	generated	generate	VBN
cord-001835-0s7ok4uw	3570	6	by	by	IN
cord-001835-0s7ok4uw	3570	7	semisynthesis	semisynthesis	NNP
cord-001835-0s7ok4uw	3570	8	using	use	VBG
cord-001835-0s7ok4uw	3570	9	expressed	express	VBD
cord-001835-0s7ok4uw	3570	10	protein	protein	NN
cord-001835-0s7ok4uw	3570	11	ligation	ligation	NN
cord-001835-0s7ok4uw	3570	12	(	(	-LRB-
cord-001835-0s7ok4uw	3570	13	EPL	EPL	NNP
cord-001835-0s7ok4uw	3570	14	)	)	-RRB-
cord-001835-0s7ok4uw	3570	15	.	.	.
cord-001835-0s7ok4uw	3571	1	The	the	DT
cord-001835-0s7ok4uw	3571	2	resulting	result	VBG
cord-001835-0s7ok4uw	3571	3	Cys-	Cys-	NNP
cord-001835-0s7ok4uw	3571	4	,	,	,
cord-001835-0s7ok4uw	3571	5	Sec	Sec	NNP
cord-001835-0s7ok4uw	3571	6	-	-	HYPH
cord-001835-0s7ok4uw	3571	7	and	and	CC
cord-001835-0s7ok4uw	3571	8	Hcy	Hcy	NNP
cord-001835-0s7ok4uw	3571	9	-	-	HYPH
cord-001835-0s7ok4uw	3571	10	sortase	sortase	NN
cord-001835-0s7ok4uw	3571	11	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3571	12	were	be	VBD
cord-001835-0s7ok4uw	3571	13	characterized	characterize	VBN
cord-001835-0s7ok4uw	3571	14	and	and	CC
cord-001835-0s7ok4uw	3571	15	showed	show	VBD
cord-001835-0s7ok4uw	3571	16	a	a	DT
cord-001835-0s7ok4uw	3571	17	moderate	moderate	JJ
cord-001835-0s7ok4uw	3571	18	2	2	CD
cord-001835-0s7ok4uw	3571	19	-	-	HYPH
cord-001835-0s7ok4uw	3571	20	3-fold	3-fold	JJ
cord-001835-0s7ok4uw	3571	21	reduction	reduction	NN
cord-001835-0s7ok4uw	3571	22	of	of	IN
cord-001835-0s7ok4uw	3571	23	activity	activity	NN
cord-001835-0s7ok4uw	3571	24	for	for	IN
cord-001835-0s7ok4uw	3571	25	Sec	Sec	NNP
cord-001835-0s7ok4uw	3571	26	-	-	HYPH
cord-001835-0s7ok4uw	3571	27	sortase	sortase	NN
cord-001835-0s7ok4uw	3571	28	.	.	.
cord-001835-0s7ok4uw	3572	1	The	the	DT
cord-001835-0s7ok4uw	3572	2	activity	activity	NN
cord-001835-0s7ok4uw	3572	3	of	of	IN
cord-001835-0s7ok4uw	3572	4	Hcysortase	Hcysortase	NNP
cord-001835-0s7ok4uw	3572	5	was	be	VBD
cord-001835-0s7ok4uw	3572	6	barely	barely	RB
cord-001835-0s7ok4uw	3572	7	detectable	detectable	JJ
cord-001835-0s7ok4uw	3572	8	with	with	IN
cord-001835-0s7ok4uw	3572	9	less	less	JJR
cord-001835-0s7ok4uw	3572	10	than	than	IN
cord-001835-0s7ok4uw	3572	11	1	1	CD
cord-001835-0s7ok4uw	3572	12	%	%	NN
cord-001835-0s7ok4uw	3572	13	of	of	IN
cord-001835-0s7ok4uw	3572	14	wildtype	wildtype	JJ
cord-001835-0s7ok4uw	3572	15	activity	activity	NN
cord-001835-0s7ok4uw	3572	16	.	.	.
cord-001835-0s7ok4uw	3573	1	The	the	DT
cord-001835-0s7ok4uw	3573	2	alkylation	alkylation	NN
cord-001835-0s7ok4uw	3573	3	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3573	4	of	of	IN
cord-001835-0s7ok4uw	3573	5	the	the	DT
cord-001835-0s7ok4uw	3573	6	active	active	JJ
cord-001835-0s7ok4uw	3573	7	site	site	NN
cord-001835-0s7ok4uw	3573	8	nucleophiles	nucleophile	NNS
cord-001835-0s7ok4uw	3573	9	correlated	correlate	VBN
cord-001835-0s7ok4uw	3573	10	with	with	IN
cord-001835-0s7ok4uw	3573	11	the	the	DT
cord-001835-0s7ok4uw	3573	12	expected	expect	VBN
cord-001835-0s7ok4uw	3573	13	pKa	pKa	NNP
cord-001835-0s7ok4uw	3573	14	values	value	NNS
cord-001835-0s7ok4uw	3573	15	of	of	IN
cord-001835-0s7ok4uw	3573	16	Sec	Sec	NNP
cord-001835-0s7ok4uw	3573	17	,	,	,
cord-001835-0s7ok4uw	3573	18	Cys	Cys	NNP
cord-001835-0s7ok4uw	3573	19	and	and	CC
cord-001835-0s7ok4uw	3573	20	Hcy	Hcy	NNP
cord-001835-0s7ok4uw	3573	21	.	.	.
cord-001835-0s7ok4uw	3574	1	Analysis	analysis	NN
cord-001835-0s7ok4uw	3574	2	of	of	IN
cord-001835-0s7ok4uw	3574	3	the	the	DT
cord-001835-0s7ok4uw	3574	4	pH	pH	NNP
cord-001835-0s7ok4uw	3574	5	dependency	dependency	NN
cord-001835-0s7ok4uw	3574	6	of	of	IN
cord-001835-0s7ok4uw	3574	7	the	the	DT
cord-001835-0s7ok4uw	3574	8	transpeptidation	transpeptidation	NN
cord-001835-0s7ok4uw	3574	9	reactions	reaction	NNS
cord-001835-0s7ok4uw	3574	10	showed	show	VBD
cord-001835-0s7ok4uw	3574	11	that	that	IN
cord-001835-0s7ok4uw	3574	12	the	the	DT
cord-001835-0s7ok4uw	3574	13	activity	activity	NN
cord-001835-0s7ok4uw	3574	14	optimum	optimum	NN
cord-001835-0s7ok4uw	3574	15	of	of	IN
cord-001835-0s7ok4uw	3574	16	Sec	Sec	NNP
cord-001835-0s7ok4uw	3574	17	-	-	HYPH
cord-001835-0s7ok4uw	3574	18	sortase	sortase	NNP
cord-001835-0s7ok4uw	3574	19	was	be	VBD
cord-001835-0s7ok4uw	3574	20	shifted	shift	VBN
cord-001835-0s7ok4uw	3574	21	towards	towards	IN
cord-001835-0s7ok4uw	3574	22	more	more	RBR
cord-001835-0s7ok4uw	3574	23	acidic	acidic	JJ
cord-001835-0s7ok4uw	3574	24	conditions	condition	NNS
cord-001835-0s7ok4uw	3574	25	.	.	.
cord-001835-0s7ok4uw	3575	1	These	these	DT
cord-001835-0s7ok4uw	3575	2	investigations	investigation	NNS
cord-001835-0s7ok4uw	3575	3	provide	provide	VBP
cord-001835-0s7ok4uw	3575	4	further	further	JJ
cord-001835-0s7ok4uw	3575	5	insights	insight	NNS
cord-001835-0s7ok4uw	3575	6	into	into	IN
cord-001835-0s7ok4uw	3575	7	the	the	DT
cord-001835-0s7ok4uw	3575	8	reaction	reaction	NN
cord-001835-0s7ok4uw	3575	9	mechanism	mechanism	NN
cord-001835-0s7ok4uw	3575	10	of	of	IN
cord-001835-0s7ok4uw	3575	11	sortase	sortase	NNP
cord-001835-0s7ok4uw	3575	12	A	A	NNP
cord-001835-0s7ok4uw	3575	13	and	and	CC
cord-001835-0s7ok4uw	3575	14	the	the	DT
cord-001835-0s7ok4uw	3575	15	semisynthetic	semisynthetic	JJ
cord-001835-0s7ok4uw	3575	16	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3575	17	may	may	MD
cord-001835-0s7ok4uw	3575	18	provide	provide	VB
cord-001835-0s7ok4uw	3575	19	new	new	JJ
cord-001835-0s7ok4uw	3575	20	tool	tool	NN
cord-001835-0s7ok4uw	3575	21	for	for	IN
cord-001835-0s7ok4uw	3575	22	further	further	JJ
cord-001835-0s7ok4uw	3575	23	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	3575	24	studies	study	NNS
cord-001835-0s7ok4uw	3575	25	.	.	.
cord-001835-0s7ok4uw	3576	1	Propanediol	propanediol	NN
cord-001835-0s7ok4uw	3576	2	oxidoreductase	oxidoreductase	NN
cord-001835-0s7ok4uw	3576	3	from	from	IN
cord-001835-0s7ok4uw	3576	4	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	3576	5	coli	coli	NNS
cord-001835-0s7ok4uw	3576	6	(	(	-LRB-
cord-001835-0s7ok4uw	3576	7	FucO	FucO	NNP
cord-001835-0s7ok4uw	3576	8	)	)	-RRB-
cord-001835-0s7ok4uw	3576	9	uses	use	VBZ
cord-001835-0s7ok4uw	3576	10	NADH	NADH	NNP
cord-001835-0s7ok4uw	3576	11	/	/	SYM
cord-001835-0s7ok4uw	3576	12	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	3576	13	as	as	IN
cord-001835-0s7ok4uw	3576	14	cofactors	cofactor	NNS
cord-001835-0s7ok4uw	3576	15	to	to	TO
cord-001835-0s7ok4uw	3576	16	catalyze	catalyze	VB
cord-001835-0s7ok4uw	3576	17	the	the	DT
cord-001835-0s7ok4uw	3576	18	conversion	conversion	NN
cord-001835-0s7ok4uw	3576	19	of	of	IN
cord-001835-0s7ok4uw	3576	20	S	S	NNP
cord-001835-0s7ok4uw	3576	21	-	-	HYPH
cord-001835-0s7ok4uw	3576	22	lactaldehyde	lactaldehyde	NNP
cord-001835-0s7ok4uw	3576	23	to	to	IN
cord-001835-0s7ok4uw	3576	24	S-1,2-propanediol	s-1,2-propanediol	NN
cord-001835-0s7ok4uw	3576	25	and	and	CC
cord-001835-0s7ok4uw	3576	26	vice	vice	NN
cord-001835-0s7ok4uw	3576	27	versa	versa	RB
cord-001835-0s7ok4uw	3576	28	.	.	.
cord-001835-0s7ok4uw	3577	1	FucO	FucO	NNP
cord-001835-0s7ok4uw	3577	2	is	be	VBZ
cord-001835-0s7ok4uw	3577	3	an	an	DT
cord-001835-0s7ok4uw	3577	4	attractive	attractive	JJ
cord-001835-0s7ok4uw	3577	5	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3577	6	in	in	IN
cord-001835-0s7ok4uw	3577	7	the	the	DT
cord-001835-0s7ok4uw	3577	8	search	search	NN
cord-001835-0s7ok4uw	3577	9	for	for	IN
cord-001835-0s7ok4uw	3577	10	possible	possible	JJ
cord-001835-0s7ok4uw	3577	11	biocatalysts	biocatalyst	NNS
cord-001835-0s7ok4uw	3577	12	producing	produce	VBG
cord-001835-0s7ok4uw	3577	13	a	a	DT
cord-001835-0s7ok4uw	3577	14	-	-	HYPH
cord-001835-0s7ok4uw	3577	15	hydroxy	hydroxy	JJ
cord-001835-0s7ok4uw	3577	16	aldehydes	aldehyde	NNS
cord-001835-0s7ok4uw	3577	17	,	,	,
cord-001835-0s7ok4uw	3577	18	which	which	WDT
cord-001835-0s7ok4uw	3577	19	are	be	VBP
cord-001835-0s7ok4uw	3577	20	important	important	JJ
cord-001835-0s7ok4uw	3577	21	for	for	IN
cord-001835-0s7ok4uw	3577	22	the	the	DT
cord-001835-0s7ok4uw	3577	23	synthesis	synthesis	NN
cord-001835-0s7ok4uw	3577	24	of	of	IN
cord-001835-0s7ok4uw	3577	25	natural	natural	JJ
cord-001835-0s7ok4uw	3577	26	products	product	NNS
cord-001835-0s7ok4uw	3577	27	and	and	CC
cord-001835-0s7ok4uw	3577	28	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3577	29	drugs	drug	NNS
cord-001835-0s7ok4uw	3577	30	.	.	.
cord-001835-0s7ok4uw	3578	1	Enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3578	2	catalyzing	catalyze	VBG
cord-001835-0s7ok4uw	3578	3	these	these	DT
cord-001835-0s7ok4uw	3578	4	types	type	NNS
cord-001835-0s7ok4uw	3578	5	of	of	IN
cord-001835-0s7ok4uw	3578	6	reactions	reaction	NNS
cord-001835-0s7ok4uw	3578	7	are	be	VBP
cord-001835-0s7ok4uw	3578	8	unique	unique	JJ
cord-001835-0s7ok4uw	3578	9	in	in	IN
cord-001835-0s7ok4uw	3578	10	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3578	11	power	power	NN
cord-001835-0s7ok4uw	3578	12	and	and	CC
cord-001835-0s7ok4uw	3578	13	stereoselectivity	stereoselectivity	NN
cord-001835-0s7ok4uw	3578	14	.	.	.
cord-001835-0s7ok4uw	3579	1	The	the	DT
cord-001835-0s7ok4uw	3579	2	usage	usage	NN
cord-001835-0s7ok4uw	3579	3	of	of	IN
cord-001835-0s7ok4uw	3579	4	FucO	FucO	NNP
cord-001835-0s7ok4uw	3579	5	in	in	IN
cord-001835-0s7ok4uw	3579	6	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3579	7	industry	industry	NN
cord-001835-0s7ok4uw	3579	8	is	be	VBZ
cord-001835-0s7ok4uw	3579	9	limited	limit	VBN
cord-001835-0s7ok4uw	3579	10	by	by	IN
cord-001835-0s7ok4uw	3579	11	the	the	DT
cord-001835-0s7ok4uw	3579	12	restricted	restrict	VBN
cord-001835-0s7ok4uw	3579	13	substrate	substrate	NN
cord-001835-0s7ok4uw	3579	14	scope	scope	NN
cord-001835-0s7ok4uw	3579	15	,	,	,
cord-001835-0s7ok4uw	3579	16	which	which	WDT
cord-001835-0s7ok4uw	3579	17	makes	make	VBZ
cord-001835-0s7ok4uw	3579	18	FucO	FucO	NNP
cord-001835-0s7ok4uw	3579	19	inactive	inactive	JJ
cord-001835-0s7ok4uw	3579	20	with	with	IN
cord-001835-0s7ok4uw	3579	21	larger	large	JJR
cord-001835-0s7ok4uw	3579	22	phenyl	phenyl	NN
cord-001835-0s7ok4uw	3579	23	-	-	HYPH
cord-001835-0s7ok4uw	3579	24	substituted	substitute	VBN
cord-001835-0s7ok4uw	3579	25	alcohols	alcohol	NNS
cord-001835-0s7ok4uw	3579	26	.	.	.
cord-001835-0s7ok4uw	3580	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3580	2	used	use	VBD
cord-001835-0s7ok4uw	3580	3	reengineering	reengineering	NN
cord-001835-0s7ok4uw	3580	4	and	and	CC
cord-001835-0s7ok4uw	3580	5	directed	direct	VBN
cord-001835-0s7ok4uw	3580	6	evolution	evolution	NN
cord-001835-0s7ok4uw	3580	7	to	to	TO
cord-001835-0s7ok4uw	3580	8	enable	enable	VB
cord-001835-0s7ok4uw	3580	9	FucO	FucO	NNP
cord-001835-0s7ok4uw	3580	10	to	to	TO
cord-001835-0s7ok4uw	3580	11	catalyze	catalyze	VB
cord-001835-0s7ok4uw	3580	12	the	the	DT
cord-001835-0s7ok4uw	3580	13	regio	regio	NN
cord-001835-0s7ok4uw	3580	14	-	-	,
cord-001835-0s7ok4uw	3580	15	and	and	CC
cord-001835-0s7ok4uw	3580	16	enantioselective	enantioselective	JJ
cord-001835-0s7ok4uw	3580	17	oxidation	oxidation	NN
cord-001835-0s7ok4uw	3580	18	of	of	IN
cord-001835-0s7ok4uw	3580	19	arylsubstituted	arylsubstituted	JJ
cord-001835-0s7ok4uw	3580	20	vicinal	vicinal	NNP
cord-001835-0s7ok4uw	3580	21	diols	diol	NNS
cord-001835-0s7ok4uw	3580	22	,	,	,
cord-001835-0s7ok4uw	3580	23	such	such	JJ
cord-001835-0s7ok4uw	3580	24	as	as	IN
cord-001835-0s7ok4uw	3580	25	phenylpropanediols	phenylpropanediols	NNP
cord-001835-0s7ok4uw	3580	26	,	,	,
cord-001835-0s7ok4uw	3580	27	into	into	IN
cord-001835-0s7ok4uw	3580	28	a	a	DT
cord-001835-0s7ok4uw	3580	29	-	-	HYPH
cord-001835-0s7ok4uw	3580	30	hydroxy	hydroxy	JJ
cord-001835-0s7ok4uw	3580	31	aldehyde	aldehyde	NN
cord-001835-0s7ok4uw	3580	32	products	product	NNS
cord-001835-0s7ok4uw	3580	33	.	.	.
cord-001835-0s7ok4uw	3581	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3581	2	mutated	mutate	VBD
cord-001835-0s7ok4uw	3581	3	amino	amino	NN
cord-001835-0s7ok4uw	3581	4	acids	acid	NNS
cord-001835-0s7ok4uw	3581	5	considered	consider	VBN
cord-001835-0s7ok4uw	3581	6	to	to	TO
cord-001835-0s7ok4uw	3581	7	restrict	restrict	VB
cord-001835-0s7ok4uw	3581	8	the	the	DT
cord-001835-0s7ok4uw	3581	9	entry	entry	NN
cord-001835-0s7ok4uw	3581	10	into	into	IN
cord-001835-0s7ok4uw	3581	11	the	the	DT
cord-001835-0s7ok4uw	3581	12	active	active	JJ
cord-001835-0s7ok4uw	3581	13	site	site	NN
cord-001835-0s7ok4uw	3581	14	,	,	,
cord-001835-0s7ok4uw	3581	15	and	and	CC
cord-001835-0s7ok4uw	3581	16	modeled	model	VBD
cord-001835-0s7ok4uw	3581	17	the	the	DT
cord-001835-0s7ok4uw	3581	18	mutants	mutant	NNS
cord-001835-0s7ok4uw	3581	19	that	that	WDT
cord-001835-0s7ok4uw	3581	20	were	be	VBD
cord-001835-0s7ok4uw	3581	21	most	most	RBS
cord-001835-0s7ok4uw	3581	22	active	active	JJ
cord-001835-0s7ok4uw	3581	23	with	with	IN
cord-001835-0s7ok4uw	3581	24	the	the	DT
cord-001835-0s7ok4uw	3581	25	substrates	substrate	NNS
cord-001835-0s7ok4uw	3581	26	phenylacetaldehyde	phenylacetaldehyde	NNP
cord-001835-0s7ok4uw	3581	27	and	and	CC
cord-001835-0s7ok4uw	3581	28	S-3-phenyl-1,2-propanediol	S-3-phenyl-1,2-propanediol	NNP
cord-001835-0s7ok4uw	3581	29	and	and	CC
cord-001835-0s7ok4uw	3581	30	performed	perform	VBD
cord-001835-0s7ok4uw	3581	31	docking	docking	NN
cord-001835-0s7ok4uw	3581	32	studies	study	NNS
cord-001835-0s7ok4uw	3581	33	with	with	IN
cord-001835-0s7ok4uw	3581	34	them	-PRON-	PRP
cord-001835-0s7ok4uw	3581	35	.	.	.
cord-001835-0s7ok4uw	3582	1	As	as	IN
cord-001835-0s7ok4uw	3582	2	expected	expect	VBN
cord-001835-0s7ok4uw	3582	3	,	,	,
cord-001835-0s7ok4uw	3582	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3582	5	experimental	experimental	JJ
cord-001835-0s7ok4uw	3582	6	and	and	CC
cord-001835-0s7ok4uw	3582	7	in	in	IN
cord-001835-0s7ok4uw	3582	8	silico	silico	NN
cord-001835-0s7ok4uw	3582	9	results	result	NNS
cord-001835-0s7ok4uw	3582	10	show	show	VBP
cord-001835-0s7ok4uw	3582	11	that	that	IN
cord-001835-0s7ok4uw	3582	12	the	the	DT
cord-001835-0s7ok4uw	3582	13	mutations	mutation	NNS
cord-001835-0s7ok4uw	3582	14	enlarge	enlarge	VBP
cord-001835-0s7ok4uw	3582	15	the	the	DT
cord-001835-0s7ok4uw	3582	16	active	active	JJ
cord-001835-0s7ok4uw	3582	17	site	site	NN
cord-001835-0s7ok4uw	3582	18	cavity	cavity	NN
cord-001835-0s7ok4uw	3582	19	and	and	CC
cord-001835-0s7ok4uw	3582	20	enable	enable	VB
cord-001835-0s7ok4uw	3582	21	the	the	DT
cord-001835-0s7ok4uw	3582	22	mutant	mutant	JJ
cord-001835-0s7ok4uw	3582	23	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3582	24	to	to	TO
cord-001835-0s7ok4uw	3582	25	accommodate	accommodate	VB
cord-001835-0s7ok4uw	3582	26	the	the	DT
cord-001835-0s7ok4uw	3582	27	new	new	JJ
cord-001835-0s7ok4uw	3582	28	substrates	substrate	NNS
cord-001835-0s7ok4uw	3582	29	.	.	.
cord-001835-0s7ok4uw	3583	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3583	2	also	also	RB
cord-001835-0s7ok4uw	3583	3	found	find	VBD
cord-001835-0s7ok4uw	3583	4	specific	specific	JJ
cord-001835-0s7ok4uw	3583	5	amino	amino	NN
cord-001835-0s7ok4uw	3583	6	acids	acid	NNS
cord-001835-0s7ok4uw	3583	7	in	in	IN
cord-001835-0s7ok4uw	3583	8	the	the	DT
cord-001835-0s7ok4uw	3583	9	active	active	JJ
cord-001835-0s7ok4uw	3583	10	site	site	NN
cord-001835-0s7ok4uw	3583	11	,	,	,
cord-001835-0s7ok4uw	3583	12	which	which	WDT
cord-001835-0s7ok4uw	3583	13	need	need	VBP
cord-001835-0s7ok4uw	3583	14	to	to	TO
cord-001835-0s7ok4uw	3583	15	be	be	VB
cord-001835-0s7ok4uw	3583	16	conserved	conserve	VBN
cord-001835-0s7ok4uw	3583	17	to	to	TO
cord-001835-0s7ok4uw	3583	18	allow	allow	VB
cord-001835-0s7ok4uw	3583	19	the	the	DT
cord-001835-0s7ok4uw	3583	20	substrates	substrate	NNS
cord-001835-0s7ok4uw	3583	21	to	to	TO
cord-001835-0s7ok4uw	3583	22	make	make	VB
cord-001835-0s7ok4uw	3583	23	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	3583	24	interactions	interaction	NNS
cord-001835-0s7ok4uw	3583	25	.	.	.
cord-001835-0s7ok4uw	3584	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	3584	2	,	,	,
cord-001835-0s7ok4uw	3584	3	an	an	DT
cord-001835-0s7ok4uw	3584	4	asparagine	asparagine	JJ
cord-001835-0s7ok4uw	3584	5	residue	residue	NN
cord-001835-0s7ok4uw	3584	6	makes	make	VBZ
cord-001835-0s7ok4uw	3584	7	the	the	DT
cord-001835-0s7ok4uw	3584	8	mutant	mutant	JJ
cord-001835-0s7ok4uw	3584	9	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3584	10	able	able	JJ
cord-001835-0s7ok4uw	3584	11	to	to	TO
cord-001835-0s7ok4uw	3584	12	discriminate	discriminate	VB
cord-001835-0s7ok4uw	3584	13	between	between	IN
cord-001835-0s7ok4uw	3584	14	phenylacetaldehyde	phenylacetaldehyde	NNP
cord-001835-0s7ok4uw	3584	15	and	and	CC
cord-001835-0s7ok4uw	3584	16	S-3-phenyl-1,2-propanediol	S-3-phenyl-1,2-propanediol	NNP
cord-001835-0s7ok4uw	3584	17	.	.	.
cord-001835-0s7ok4uw	3585	1	In	in	IN
cord-001835-0s7ok4uw	3585	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	3585	3	,	,	,
cord-001835-0s7ok4uw	3585	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3585	5	successfully	successfully	RB
cord-001835-0s7ok4uw	3585	6	re	re	VBP
cord-001835-0s7ok4uw	3585	7	-	-	VBN
cord-001835-0s7ok4uw	3585	8	engineered	engineer	VBN
cord-001835-0s7ok4uw	3585	9	the	the	DT
cord-001835-0s7ok4uw	3585	10	specialist	specialist	NN
cord-001835-0s7ok4uw	3585	11	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3585	12	FucO	FucO	NNP
cord-001835-0s7ok4uw	3585	13	to	to	TO
cord-001835-0s7ok4uw	3585	14	accept	accept	VB
cord-001835-0s7ok4uw	3585	15	also	also	RB
cord-001835-0s7ok4uw	3585	16	bulkier	bulky	JJR
cord-001835-0s7ok4uw	3585	17	molecules	molecule	NNS
cord-001835-0s7ok4uw	3585	18	as	as	IN
cord-001835-0s7ok4uw	3585	19	substrates	substrate	NNS
cord-001835-0s7ok4uw	3585	20	,	,	,
cord-001835-0s7ok4uw	3585	21	thereby	thereby	RB
cord-001835-0s7ok4uw	3585	22	making	make	VBG
cord-001835-0s7ok4uw	3585	23	it	-PRON-	PRP
cord-001835-0s7ok4uw	3585	24	more	more	RBR
cord-001835-0s7ok4uw	3585	25	useful	useful	JJ
cord-001835-0s7ok4uw	3585	26	for	for	IN
cord-001835-0s7ok4uw	3585	27	industrial	industrial	JJ
cord-001835-0s7ok4uw	3585	28	purposes	purpose	NNS
cord-001835-0s7ok4uw	3585	29	.	.	.
cord-001835-0s7ok4uw	3586	1	One	one	CD
cord-001835-0s7ok4uw	3586	2	way	way	NN
cord-001835-0s7ok4uw	3586	3	to	to	TO
cord-001835-0s7ok4uw	3586	4	gain	gain	VB
cord-001835-0s7ok4uw	3586	5	insight	insight	NN
cord-001835-0s7ok4uw	3586	6	into	into	IN
cord-001835-0s7ok4uw	3586	7	the	the	DT
cord-001835-0s7ok4uw	3586	8	sequence	sequence	NN
cord-001835-0s7ok4uw	3586	9	-	-	HYPH
cord-001835-0s7ok4uw	3586	10	structure	structure	NN
cord-001835-0s7ok4uw	3586	11	-	-	HYPH
cord-001835-0s7ok4uw	3586	12	function	function	NN
cord-001835-0s7ok4uw	3586	13	relationship	relationship	NN
cord-001835-0s7ok4uw	3586	14	in	in	IN
cord-001835-0s7ok4uw	3586	15	proteins	protein	NNS
cord-001835-0s7ok4uw	3586	16	is	be	VBZ
cord-001835-0s7ok4uw	3586	17	to	to	IN
cord-001835-0s7ok4uw	3586	18	de	de	NNP
cord-001835-0s7ok4uw	3586	19	novo	novo	NNP
cord-001835-0s7ok4uw	3586	20	design	design	NN
cord-001835-0s7ok4uw	3586	21	artificial	artificial	JJ
cord-001835-0s7ok4uw	3586	22	proteins	protein	NNS
cord-001835-0s7ok4uw	3586	23	.	.	.
cord-001835-0s7ok4uw	3587	1	Despite	despite	IN
cord-001835-0s7ok4uw	3587	2	impressive	impressive	JJ
cord-001835-0s7ok4uw	3587	3	successes	success	NNS
cord-001835-0s7ok4uw	3587	4	in	in	IN
cord-001835-0s7ok4uw	3587	5	de	de	NNP
cord-001835-0s7ok4uw	3587	6	novo	novo	NNP
cord-001835-0s7ok4uw	3587	7	protein	protein	NNP
cord-001835-0s7ok4uw	3587	8	design	design	NN
cord-001835-0s7ok4uw	3587	9	,	,	,
cord-001835-0s7ok4uw	3587	10	designing	design	VBG
cord-001835-0s7ok4uw	3587	11	a	a	DT
cord-001835-0s7ok4uw	3587	12	folded	fold	VBN
cord-001835-0s7ok4uw	3587	13	protein	protein	NN
cord-001835-0s7ok4uw	3587	14	of	of	IN
cord-001835-0s7ok4uw	3587	15	more	more	JJR
cord-001835-0s7ok4uw	3587	16	than	than	IN
cord-001835-0s7ok4uw	3587	17	100	100	CD
cord-001835-0s7ok4uw	3587	18	amino	amino	NN
cord-001835-0s7ok4uw	3587	19	acids	acid	NNS
cord-001835-0s7ok4uw	3587	20	still	still	RB
cord-001835-0s7ok4uw	3587	21	remains	remain	VBZ
cord-001835-0s7ok4uw	3587	22	a	a	DT
cord-001835-0s7ok4uw	3587	23	challenge	challenge	NN
cord-001835-0s7ok4uw	3587	24	.	.	.
cord-001835-0s7ok4uw	3588	1	Using	use	VBG
cord-001835-0s7ok4uw	3588	2	this	this	DT
cord-001835-0s7ok4uw	3588	3	approach	approach	NN
cord-001835-0s7ok4uw	3588	4	,	,	,
cord-001835-0s7ok4uw	3588	5	an	an	DT
cord-001835-0s7ok4uw	3588	6	idealized	idealized	JJ
cord-001835-0s7ok4uw	3588	7	(	(	-LRB-
cord-001835-0s7ok4uw	3588	8	beta/	beta/	CD
cord-001835-0s7ok4uw	3588	9	alpha)8	alpha)8	NN
cord-001835-0s7ok4uw	3588	10	fold	fold	NN
cord-001835-0s7ok4uw	3588	11	protein	protein	NN
cord-001835-0s7ok4uw	3588	12	was	be	VBD
cord-001835-0s7ok4uw	3588	13	designed	design	VBN
cord-001835-0s7ok4uw	3588	14	leading	lead	VBG
cord-001835-0s7ok4uw	3588	15	to	to	IN
cord-001835-0s7ok4uw	3588	16	the	the	DT
cord-001835-0s7ok4uw	3588	17	production	production	NN
cord-001835-0s7ok4uw	3588	18	of	of	IN
cord-001835-0s7ok4uw	3588	19	a	a	DT
cord-001835-0s7ok4uw	3588	20	protein	protein	NN
cord-001835-0s7ok4uw	3588	21	of	of	IN
cord-001835-0s7ok4uw	3588	22	216	216	CD
cord-001835-0s7ok4uw	3588	23	amino	amino	JJ
cord-001835-0s7ok4uw	3588	24	acids	acid	NNS
cord-001835-0s7ok4uw	3588	25	(	(	-LRB-
cord-001835-0s7ok4uw	3588	26	Octarellin	Octarellin	NNP
cord-001835-0s7ok4uw	3588	27	V	V	NNP
cord-001835-0s7ok4uw	3588	28	)	)	-RRB-
cord-001835-0s7ok4uw	3588	29	.	.	.
cord-001835-0s7ok4uw	3589	1	This	this	DT
cord-001835-0s7ok4uw	3589	2	protein	protein	NN
cord-001835-0s7ok4uw	3589	3	showed	show	VBD
cord-001835-0s7ok4uw	3589	4	a	a	DT
cord-001835-0s7ok4uw	3589	5	low	low	JJ
cord-001835-0s7ok4uw	3589	6	solubility	solubility	NN
cord-001835-0s7ok4uw	3589	7	and	and	CC
cord-001835-0s7ok4uw	3589	8	stability	stability	NN
cord-001835-0s7ok4uw	3589	9	.	.	.
cord-001835-0s7ok4uw	3590	1	Through	through	IN
cord-001835-0s7ok4uw	3590	2	directed	direct	VBN
cord-001835-0s7ok4uw	3590	3	evolution	evolution	NN
cord-001835-0s7ok4uw	3590	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3590	5	produced	produce	VBD
cord-001835-0s7ok4uw	3590	6	a	a	DT
cord-001835-0s7ok4uw	3590	7	soluble	soluble	JJ
cord-001835-0s7ok4uw	3590	8	variant	variant	NN
cord-001835-0s7ok4uw	3590	9	,	,	,
cord-001835-0s7ok4uw	3590	10	Octarellin	octarellin	JJ
cord-001835-0s7ok4uw	3590	11	V.1	v.1	NN
cord-001835-0s7ok4uw	3590	12	.	.	.
cord-001835-0s7ok4uw	3591	1	The	the	DT
cord-001835-0s7ok4uw	3591	2	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	3591	3	characterization	characterization	NN
cord-001835-0s7ok4uw	3591	4	of	of	IN
cord-001835-0s7ok4uw	3591	5	Octarellin	octarellin	JJ
cord-001835-0s7ok4uw	3591	6	V.1	v.1	NN
cord-001835-0s7ok4uw	3591	7	shows	show	VBZ
cord-001835-0s7ok4uw	3591	8	a	a	DT
cord-001835-0s7ok4uw	3591	9	well	well	RB
cord-001835-0s7ok4uw	3591	10	folded	fold	VBN
cord-001835-0s7ok4uw	3591	11	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	3591	12	and	and	CC
cord-001835-0s7ok4uw	3591	13	thermostable	thermostable	JJ
cord-001835-0s7ok4uw	3591	14	protein	protein	NN
cord-001835-0s7ok4uw	3591	15	with	with	IN
cord-001835-0s7ok4uw	3591	16	a	a	DT
cord-001835-0s7ok4uw	3591	17	Tm	Tm	NNP
cord-001835-0s7ok4uw	3591	18	over	over	IN
cord-001835-0s7ok4uw	3591	19	908C.	908c.	CD
cord-001835-0s7ok4uw	3592	1	However	however	RB
cord-001835-0s7ok4uw	3592	2	,	,	,
cord-001835-0s7ok4uw	3592	3	after	after	IN
cord-001835-0s7ok4uw	3592	4	several	several	JJ
cord-001835-0s7ok4uw	3592	5	screenings	screening	NNS
cord-001835-0s7ok4uw	3592	6	,	,	,
cord-001835-0s7ok4uw	3592	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	3592	8	could	could	MD
cord-001835-0s7ok4uw	3592	9	not	not	RB
cord-001835-0s7ok4uw	3592	10	find	find	VB
cord-001835-0s7ok4uw	3592	11	crystallization	crystallization	NN
cord-001835-0s7ok4uw	3592	12	conditions	condition	NNS
cord-001835-0s7ok4uw	3592	13	for	for	IN
cord-001835-0s7ok4uw	3592	14	this	this	DT
cord-001835-0s7ok4uw	3592	15	protein	protein	NN
cord-001835-0s7ok4uw	3592	16	.	.	.
cord-001835-0s7ok4uw	3593	1	As	as	IN
cord-001835-0s7ok4uw	3593	2	an	an	DT
cord-001835-0s7ok4uw	3593	3	alternative	alternative	NN
cord-001835-0s7ok4uw	3593	4	,	,	,
cord-001835-0s7ok4uw	3593	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3593	6	decided	decide	VBD
cord-001835-0s7ok4uw	3593	7	to	to	TO
cord-001835-0s7ok4uw	3593	8	co	co	VB
cord-001835-0s7ok4uw	3593	9	-	-	VB
cord-001835-0s7ok4uw	3593	10	crystallize	crystallize	VB
cord-001835-0s7ok4uw	3593	11	Octarellin	octarellin	JJ
cord-001835-0s7ok4uw	3593	12	V.1	v.1	NN
cord-001835-0s7ok4uw	3593	13	with	with	IN
cord-001835-0s7ok4uw	3593	14	a	a	DT
cord-001835-0s7ok4uw	3593	15	protein	protein	NN
cord-001835-0s7ok4uw	3593	16	partner	partner	NN
cord-001835-0s7ok4uw	3593	17	that	that	WDT
cord-001835-0s7ok4uw	3593	18	helps	help	VBZ
cord-001835-0s7ok4uw	3593	19	the	the	DT
cord-001835-0s7ok4uw	3593	20	crystallization	crystallization	NN
cord-001835-0s7ok4uw	3593	21	process	process	NN
cord-001835-0s7ok4uw	3593	22	.	.	.
cord-001835-0s7ok4uw	3594	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3594	2	used	use	VBD
cord-001835-0s7ok4uw	3594	3	2	2	CD
cord-001835-0s7ok4uw	3594	4	protein	protein	NN
cord-001835-0s7ok4uw	3594	5	partners	partner	NNS
cord-001835-0s7ok4uw	3594	6	:	:	:
cord-001835-0s7ok4uw	3594	7	alpha	alpha	NN
cord-001835-0s7ok4uw	3594	8	-	-	HYPH
cord-001835-0s7ok4uw	3594	9	Reps	Reps	NNPS
cord-001835-0s7ok4uw	3594	10	and	and	CC
cord-001835-0s7ok4uw	3594	11	nanobodies	nanobodie	NNS
cord-001835-0s7ok4uw	3594	12	.	.	.
cord-001835-0s7ok4uw	3595	1	The	the	DT
cord-001835-0s7ok4uw	3595	2	first	first	JJ
cord-001835-0s7ok4uw	3595	3	one	one	NN
cord-001835-0s7ok4uw	3595	4	is	be	VBZ
cord-001835-0s7ok4uw	3595	5	characterized	characterize	VBN
cord-001835-0s7ok4uw	3595	6	to	to	TO
cord-001835-0s7ok4uw	3595	7	interact	interact	VB
cord-001835-0s7ok4uw	3595	8	through	through	IN
cord-001835-0s7ok4uw	3595	9	a	a	DT
cord-001835-0s7ok4uw	3595	10	large	large	JJ
cord-001835-0s7ok4uw	3595	11	surface	surface	NN
cord-001835-0s7ok4uw	3595	12	contact	contact	NN
cord-001835-0s7ok4uw	3595	13	,	,	,
cord-001835-0s7ok4uw	3595	14	whereas	whereas	IN
cord-001835-0s7ok4uw	3595	15	the	the	DT
cord-001835-0s7ok4uw	3595	16	second	second	JJ
cord-001835-0s7ok4uw	3595	17	is	be	VBZ
cord-001835-0s7ok4uw	3595	18	characterized	characterize	VBN
cord-001835-0s7ok4uw	3595	19	to	to	TO
cord-001835-0s7ok4uw	3595	20	recognize	recognize	VB
cord-001835-0s7ok4uw	3595	21	an	an	DT
cord-001835-0s7ok4uw	3595	22	specific	specific	JJ
cord-001835-0s7ok4uw	3595	23	small	small	JJ
cord-001835-0s7ok4uw	3595	24	epitope	epitope	NN
cord-001835-0s7ok4uw	3595	25	.	.	.
cord-001835-0s7ok4uw	3596	1	Crystallization	crystallization	NN
cord-001835-0s7ok4uw	3596	2	of	of	IN
cord-001835-0s7ok4uw	3596	3	both	both	DT
cord-001835-0s7ok4uw	3596	4	complexes	complex	NNS
cord-001835-0s7ok4uw	3596	5	was	be	VBD
cord-001835-0s7ok4uw	3596	6	performed	perform	VBN
cord-001835-0s7ok4uw	3596	7	successfully	successfully	RB
cord-001835-0s7ok4uw	3596	8	by	by	IN
cord-001835-0s7ok4uw	3596	9	vapor	vapor	NN
cord-001835-0s7ok4uw	3596	10	diffusion	diffusion	NN
cord-001835-0s7ok4uw	3596	11	and	and	CC
cord-001835-0s7ok4uw	3596	12	the	the	DT
cord-001835-0s7ok4uw	3596	13	structures	structure	NNS
cord-001835-0s7ok4uw	3596	14	were	be	VBD
cord-001835-0s7ok4uw	3596	15	solved	solve	VBN
cord-001835-0s7ok4uw	3596	16	.	.	.
cord-001835-0s7ok4uw	3597	1	The	the	DT
cord-001835-0s7ok4uw	3597	2	experimental	experimental	JJ
cord-001835-0s7ok4uw	3597	3	structures	structure	NNS
cord-001835-0s7ok4uw	3597	4	correspond	correspond	VBP
cord-001835-0s7ok4uw	3597	5	to	to	IN
cord-001835-0s7ok4uw	3597	6	the	the	DT
cord-001835-0s7ok4uw	3597	7	first	first	JJ
cord-001835-0s7ok4uw	3597	8	for	for	IN
cord-001835-0s7ok4uw	3597	9	an	an	DT
cord-001835-0s7ok4uw	3597	10	artificial	artificial	JJ
cord-001835-0s7ok4uw	3597	11	protein	protein	NN
cord-001835-0s7ok4uw	3597	12	of	of	IN
cord-001835-0s7ok4uw	3597	13	this	this	DT
cord-001835-0s7ok4uw	3597	14	size	size	NN
cord-001835-0s7ok4uw	3597	15	and	and	CC
cord-001835-0s7ok4uw	3597	16	it	-PRON-	PRP
cord-001835-0s7ok4uw	3597	17	will	will	MD
cord-001835-0s7ok4uw	3597	18	allow	allow	VB
cord-001835-0s7ok4uw	3597	19	to	to	TO
cord-001835-0s7ok4uw	3597	20	criticize	criticize	VB
cord-001835-0s7ok4uw	3597	21	the	the	DT
cord-001835-0s7ok4uw	3597	22	computational	computational	JJ
cord-001835-0s7ok4uw	3597	23	design	design	NN
cord-001835-0s7ok4uw	3597	24	of	of	IN
cord-001835-0s7ok4uw	3597	25	the	the	DT
cord-001835-0s7ok4uw	3597	26	Octarellin	Octarellin	NNP
cord-001835-0s7ok4uw	3597	27	V.	V.	NNP
cord-001835-0s7ok4uw	3597	28	Generation	Generation	NNP
cord-001835-0s7ok4uw	3597	29	of	of	IN
cord-001835-0s7ok4uw	3597	30	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3597	31	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3597	32	against	against	IN
cord-001835-0s7ok4uw	3597	33	membrane	membrane	NN
cord-001835-0s7ok4uw	3597	34	proteins	protein	NNS
cord-001835-0s7ok4uw	3597	35	in	in	IN
cord-001835-0s7ok4uw	3597	36	nanodiscs	nanodiscs	NN
cord-001835-0s7ok4uw	3597	37	for	for	IN
cord-001835-0s7ok4uw	3597	38	use	use	NN
cord-001835-0s7ok4uw	3597	39	in	in	IN
cord-001835-0s7ok4uw	3597	40	structural	structural	JJ
cord-001835-0s7ok4uw	3597	41	biology	biology	NN
cord-001835-0s7ok4uw	3597	42	methods	method	NNS
cord-001835-0s7ok4uw	3597	43	.	.	.
cord-001835-0s7ok4uw	3598	1	Here	here	RB
cord-001835-0s7ok4uw	3598	2	,	,	,
cord-001835-0s7ok4uw	3598	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3598	4	describe	describe	VBP
cord-001835-0s7ok4uw	3598	5	a	a	DT
cord-001835-0s7ok4uw	3598	6	robust	robust	JJ
cord-001835-0s7ok4uw	3598	7	strategy	strategy	NN
cord-001835-0s7ok4uw	3598	8	for	for	IN
cord-001835-0s7ok4uw	3598	9	generating	generate	VBG
cord-001835-0s7ok4uw	3598	10	a	a	DT
cord-001835-0s7ok4uw	3598	11	class	class	NN
cord-001835-0s7ok4uw	3598	12	of	of	IN
cord-001835-0s7ok4uw	3598	13	high	high	JJ
cord-001835-0s7ok4uw	3598	14	performance	performance	NN
cord-001835-0s7ok4uw	3598	15	antibodybased	antibodybase	VBN
cord-001835-0s7ok4uw	3598	16	affinity	affinity	NN
cord-001835-0s7ok4uw	3598	17	reagents	reagent	NNS
cord-001835-0s7ok4uw	3598	18	that	that	WDT
cord-001835-0s7ok4uw	3598	19	have	have	VBP
cord-001835-0s7ok4uw	3598	20	proven	prove	VBN
cord-001835-0s7ok4uw	3598	21	useful	useful	JJ
cord-001835-0s7ok4uw	3598	22	in	in	IN
cord-001835-0s7ok4uw	3598	23	determining	determine	VBG
cord-001835-0s7ok4uw	3598	24	the	the	DT
cord-001835-0s7ok4uw	3598	25	structures	structure	NNS
cord-001835-0s7ok4uw	3598	26	of	of	IN
cord-001835-0s7ok4uw	3598	27	relevant	relevant	JJ
cord-001835-0s7ok4uw	3598	28	functional	functional	JJ
cord-001835-0s7ok4uw	3598	29	states	state	NNS
cord-001835-0s7ok4uw	3598	30	of	of	IN
cord-001835-0s7ok4uw	3598	31	membrane	membrane	NN
cord-001835-0s7ok4uw	3598	32	proteins	protein	NNS
cord-001835-0s7ok4uw	3598	33	.	.	.
cord-001835-0s7ok4uw	3599	1	These	these	DT
cord-001835-0s7ok4uw	3599	2	reagents	reagent	NNS
cord-001835-0s7ok4uw	3599	3	are	be	VBP
cord-001835-0s7ok4uw	3599	4	Fab	fab	JJ
cord-001835-0s7ok4uw	3599	5	fragments	fragment	NNS
cord-001835-0s7ok4uw	3599	6	that	that	WDT
cord-001835-0s7ok4uw	3599	7	are	be	VBP
cord-001835-0s7ok4uw	3599	8	generated	generate	VBN
cord-001835-0s7ok4uw	3599	9	by	by	IN
cord-001835-0s7ok4uw	3599	10	phage	phage	NN
cord-001835-0s7ok4uw	3599	11	display	display	NN
cord-001835-0s7ok4uw	3599	12	from	from	IN
cord-001835-0s7ok4uw	3599	13	fully	fully	RB
cord-001835-0s7ok4uw	3599	14	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3599	15	libraries	library	NNS
cord-001835-0s7ok4uw	3599	16	and	and	CC
cord-001835-0s7ok4uw	3599	17	are	be	VBP
cord-001835-0s7ok4uw	3599	18	called	call	VBN
cord-001835-0s7ok4uw	3599	19	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3599	20	antibody	antibody	NN
cord-001835-0s7ok4uw	3599	21	fragments	fragment	NNS
cord-001835-0s7ok4uw	3599	22	,	,	,
cord-001835-0s7ok4uw	3599	23	or	or	CC
cord-001835-0s7ok4uw	3599	24	sABs	sABs	''
cord-001835-0s7ok4uw	3599	25	.	.	.
cord-001835-0s7ok4uw	3600	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3600	2	have	have	VBP
cord-001835-0s7ok4uw	3600	3	developed	develop	VBN
cord-001835-0s7ok4uw	3600	4	phage	phage	NN
cord-001835-0s7ok4uw	3600	5	display	display	NN
cord-001835-0s7ok4uw	3600	6	sorting	sorting	NN
cord-001835-0s7ok4uw	3600	7	strategies	strategy	NNS
cord-001835-0s7ok4uw	3600	8	that	that	WDT
cord-001835-0s7ok4uw	3600	9	can	can	MD
cord-001835-0s7ok4uw	3600	10	trap	trap	VB
cord-001835-0s7ok4uw	3600	11	a	a	DT
cord-001835-0s7ok4uw	3600	12	desired	desire	VBN
cord-001835-0s7ok4uw	3600	13	conformational	conformational	JJ
cord-001835-0s7ok4uw	3600	14	state	state	NN
cord-001835-0s7ok4uw	3600	15	,	,	,
cord-001835-0s7ok4uw	3600	16	making	make	VBG
cord-001835-0s7ok4uw	3600	17	it	-PRON-	PRP
cord-001835-0s7ok4uw	3600	18	accessible	accessible	JJ
cord-001835-0s7ok4uw	3600	19	to	to	IN
cord-001835-0s7ok4uw	3600	20	structural	structural	JJ
cord-001835-0s7ok4uw	3600	21	analysis	analysis	NN
cord-001835-0s7ok4uw	3600	22	,	,	,
cord-001835-0s7ok4uw	3600	23	or	or	CC
cord-001835-0s7ok4uw	3600	24	target	target	VB
cord-001835-0s7ok4uw	3600	25	a	a	DT
cord-001835-0s7ok4uw	3600	26	particular	particular	JJ
cord-001835-0s7ok4uw	3600	27	epitope	epitope	NN
cord-001835-0s7ok4uw	3600	28	on	on	IN
cord-001835-0s7ok4uw	3600	29	the	the	DT
cord-001835-0s7ok4uw	3600	30	protein	protein	NN
cord-001835-0s7ok4uw	3600	31	surface	surface	NN
cord-001835-0s7ok4uw	3600	32	.	.	.
cord-001835-0s7ok4uw	3601	1	However	however	RB
cord-001835-0s7ok4uw	3601	2	,	,	,
cord-001835-0s7ok4uw	3601	3	to	to	TO
cord-001835-0s7ok4uw	3601	4	maximize	maximize	VB
cord-001835-0s7ok4uw	3601	5	this	this	DT
cord-001835-0s7ok4uw	3601	6	technology	technology	NN
cord-001835-0s7ok4uw	3601	7	for	for	IN
cord-001835-0s7ok4uw	3601	8	membrane	membrane	NN
cord-001835-0s7ok4uw	3601	9	proteins	protein	NNS
cord-001835-0s7ok4uw	3601	10	,	,	,
cord-001835-0s7ok4uw	3601	11	several	several	JJ
cord-001835-0s7ok4uw	3601	12	limitations	limitation	NNS
cord-001835-0s7ok4uw	3601	13	of	of	IN
cord-001835-0s7ok4uw	3601	14	phage	phage	NN
cord-001835-0s7ok4uw	3601	15	display	display	NN
cord-001835-0s7ok4uw	3601	16	sorting	sorting	NN
cord-001835-0s7ok4uw	3601	17	in	in	IN
cord-001835-0s7ok4uw	3601	18	detergent	detergent	NN
cord-001835-0s7ok4uw	3601	19	formats	format	NNS
cord-001835-0s7ok4uw	3601	20	had	have	VBD
cord-001835-0s7ok4uw	3601	21	to	to	TO
cord-001835-0s7ok4uw	3601	22	be	be	VB
cord-001835-0s7ok4uw	3601	23	overcome	overcome	VBN
cord-001835-0s7ok4uw	3601	24	,	,	,
cord-001835-0s7ok4uw	3601	25	the	the	DT
cord-001835-0s7ok4uw	3601	26	greatest	great	JJS
cord-001835-0s7ok4uw	3601	27	being	being	NN
cord-001835-0s7ok4uw	3601	28	that	that	IN
cord-001835-0s7ok4uw	3601	29	using	use	VBG
cord-001835-0s7ok4uw	3601	30	detergents	detergent	NNS
cord-001835-0s7ok4uw	3601	31	can	can	MD
cord-001835-0s7ok4uw	3601	32	produce	produce	VB
cord-001835-0s7ok4uw	3601	33	non	non	JJ
cord-001835-0s7ok4uw	3601	34	-	-	JJ
cord-001835-0s7ok4uw	3601	35	native	native	JJ
cord-001835-0s7ok4uw	3601	36	conformational	conformational	JJ
cord-001835-0s7ok4uw	3601	37	biases	bias	NNS
cord-001835-0s7ok4uw	3601	38	.	.	.
cord-001835-0s7ok4uw	3602	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3602	2	sought	seek	VBD
cord-001835-0s7ok4uw	3602	3	to	to	TO
cord-001835-0s7ok4uw	3602	4	address	address	VB
cord-001835-0s7ok4uw	3602	5	these	these	DT
cord-001835-0s7ok4uw	3602	6	limitations	limitation	NNS
cord-001835-0s7ok4uw	3602	7	by	by	IN
cord-001835-0s7ok4uw	3602	8	embedding	embed	VBG
cord-001835-0s7ok4uw	3602	9	membrane	membrane	NN
cord-001835-0s7ok4uw	3602	10	proteins	protein	NNS
cord-001835-0s7ok4uw	3602	11	into	into	IN
cord-001835-0s7ok4uw	3602	12	nanodiscs	nanodiscs	JJ
cord-001835-0s7ok4uw	3602	13	,	,	,
cord-001835-0s7ok4uw	3602	14	soluble	soluble	JJ
cord-001835-0s7ok4uw	3602	15	lipidfilled	lipidfilled	JJ
cord-001835-0s7ok4uw	3602	16	discoidal	discoidal	JJ
cord-001835-0s7ok4uw	3602	17	particles	particle	NNS
cord-001835-0s7ok4uw	3602	18	,	,	,
cord-001835-0s7ok4uw	3602	19	to	to	TO
cord-001835-0s7ok4uw	3602	20	better	better	RB
cord-001835-0s7ok4uw	3602	21	mimic	mimic	VB
cord-001835-0s7ok4uw	3602	22	the	the	DT
cord-001835-0s7ok4uw	3602	23	native	native	JJ
cord-001835-0s7ok4uw	3602	24	membrane	membrane	NN
cord-001835-0s7ok4uw	3602	25	environment	environment	NN
cord-001835-0s7ok4uw	3602	26	.	.	.
cord-001835-0s7ok4uw	3603	1	Nanodiscs	Nanodiscs	NNP
cord-001835-0s7ok4uw	3603	2	stabilize	stabilize	VBP
cord-001835-0s7ok4uw	3603	3	the	the	DT
cord-001835-0s7ok4uw	3603	4	membrane	membrane	NN
cord-001835-0s7ok4uw	3603	5	protein	protein	NN
cord-001835-0s7ok4uw	3603	6	and	and	CC
cord-001835-0s7ok4uw	3603	7	allow	allow	VB
cord-001835-0s7ok4uw	3603	8	it	-PRON-	PRP
cord-001835-0s7ok4uw	3603	9	to	to	TO
cord-001835-0s7ok4uw	3603	10	respond	respond	VB
cord-001835-0s7ok4uw	3603	11	to	to	IN
cord-001835-0s7ok4uw	3603	12	conformation	conformation	NN
cord-001835-0s7ok4uw	3603	13	-	-	HYPH
cord-001835-0s7ok4uw	3603	14	inducing	induce	VBG
cord-001835-0s7ok4uw	3603	15	stimuli	stimulus	NNS
cord-001835-0s7ok4uw	3603	16	such	such	JJ
cord-001835-0s7ok4uw	3603	17	as	as	IN
cord-001835-0s7ok4uw	3603	18	ligands	ligand	NNS
cord-001835-0s7ok4uw	3603	19	,	,	,
cord-001835-0s7ok4uw	3603	20	ions	ion	NNS
cord-001835-0s7ok4uw	3603	21	and	and	CC
cord-001835-0s7ok4uw	3603	22	pH	ph	NN
cord-001835-0s7ok4uw	3604	1	during	during	IN
cord-001835-0s7ok4uw	3604	2	phage	phage	NN
cord-001835-0s7ok4uw	3604	3	display	display	NN
cord-001835-0s7ok4uw	3604	4	selections	selection	NNS
cord-001835-0s7ok4uw	3604	5	.	.	.
cord-001835-0s7ok4uw	3605	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3605	2	have	have	VBP
cord-001835-0s7ok4uw	3605	3	established	establish	VBN
cord-001835-0s7ok4uw	3605	4	and	and	CC
cord-001835-0s7ok4uw	3605	5	validated	validate	VBN
cord-001835-0s7ok4uw	3605	6	an	an	DT
cord-001835-0s7ok4uw	3605	7	improved	improved	JJ
cord-001835-0s7ok4uw	3605	8	protocol	protocol	NN
cord-001835-0s7ok4uw	3605	9	using	use	VBG
cord-001835-0s7ok4uw	3605	10	two	two	CD
cord-001835-0s7ok4uw	3605	11	membrane	membrane	NN
cord-001835-0s7ok4uw	3605	12	protein	protein	NN
cord-001835-0s7ok4uw	3605	13	systems	system	NNS
cord-001835-0s7ok4uw	3605	14	:	:	:
cord-001835-0s7ok4uw	3605	15	1	1	LS
cord-001835-0s7ok4uw	3605	16	)	)	-RRB-
cord-001835-0s7ok4uw	3605	17	Mj0480	Mj0480	NNP
cord-001835-0s7ok4uw	3605	18	,	,	,
cord-001835-0s7ok4uw	3605	19	an	an	DT
cord-001835-0s7ok4uw	3605	20	archaeal	archaeal	JJ
cord-001835-0s7ok4uw	3605	21	membrane	membrane	NN
cord-001835-0s7ok4uw	3605	22	protein	protein	NN
cord-001835-0s7ok4uw	3605	23	of	of	IN
cord-001835-0s7ok4uw	3605	24	unknown	unknown	JJ
cord-001835-0s7ok4uw	3605	25	function	function	NN
cord-001835-0s7ok4uw	3605	26	,	,	,
cord-001835-0s7ok4uw	3605	27	and	and	CC
cord-001835-0s7ok4uw	3605	28	2	2	LS
cord-001835-0s7ok4uw	3605	29	)	)	-RRB-
cord-001835-0s7ok4uw	3606	1	CorA	CorA	NNP
cord-001835-0s7ok4uw	3606	2	,	,	,
cord-001835-0s7ok4uw	3606	3	a	a	DT
cord-001835-0s7ok4uw	3606	4	pentameric	pentameric	NN
cord-001835-0s7ok4uw	3606	5	magnesium	magnesium	NN
cord-001835-0s7ok4uw	3606	6	ion	ion	NN
cord-001835-0s7ok4uw	3606	7	channel	channel	NN
cord-001835-0s7ok4uw	3606	8	.	.	.
cord-001835-0s7ok4uw	3607	1	Using	use	VBG
cord-001835-0s7ok4uw	3607	2	Mj0480	Mj0480	NNP
cord-001835-0s7ok4uw	3607	3	,	,	,
cord-001835-0s7ok4uw	3607	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3607	5	compared	compare	VBD
cord-001835-0s7ok4uw	3607	6	the	the	DT
cord-001835-0s7ok4uw	3607	7	nanodisc	nanodisc	NNP
cord-001835-0s7ok4uw	3607	8	protocol	protocol	NN
cord-001835-0s7ok4uw	3607	9	with	with	IN
cord-001835-0s7ok4uw	3607	10	the	the	DT
cord-001835-0s7ok4uw	3607	11	standard	standard	JJ
cord-001835-0s7ok4uw	3607	12	method	method	NN
cord-001835-0s7ok4uw	3607	13	performed	perform	VBN
cord-001835-0s7ok4uw	3607	14	in	in	IN
cord-001835-0s7ok4uw	3607	15	detergent	detergent	NN
cord-001835-0s7ok4uw	3607	16	,	,	,
cord-001835-0s7ok4uw	3607	17	and	and	CC
cord-001835-0s7ok4uw	3607	18	as	as	IN
cord-001835-0s7ok4uw	3607	19	an	an	DT
cord-001835-0s7ok4uw	3607	20	important	important	JJ
cord-001835-0s7ok4uw	3607	21	byproduct	byproduct	NN
cord-001835-0s7ok4uw	3607	22	,	,	,
cord-001835-0s7ok4uw	3607	23	we	-PRON-	PRP
cord-001835-0s7ok4uw	3607	24	characterized	characterize	VBD
cord-001835-0s7ok4uw	3607	25	the	the	DT
cord-001835-0s7ok4uw	3607	26	influence	influence	NN
cord-001835-0s7ok4uw	3607	27	of	of	IN
cord-001835-0s7ok4uw	3607	28	the	the	DT
cord-001835-0s7ok4uw	3607	29	membrane	membrane	NN
cord-001835-0s7ok4uw	3607	30	protein	protein	NN
cord-001835-0s7ok4uw	3607	31	environment	environment	NN
cord-001835-0s7ok4uw	3607	32	on	on	IN
cord-001835-0s7ok4uw	3607	33	the	the	DT
cord-001835-0s7ok4uw	3607	34	apparent	apparent	JJ
cord-001835-0s7ok4uw	3607	35	affinity	affinity	NN
cord-001835-0s7ok4uw	3607	36	of	of	IN
cord-001835-0s7ok4uw	3607	37	sABs	sabs	NN
cord-001835-0s7ok4uw	3607	38	to	to	IN
cord-001835-0s7ok4uw	3607	39	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3607	40	cognate	cognate	JJ
cord-001835-0s7ok4uw	3607	41	antigen	antigen	NN
cord-001835-0s7ok4uw	3607	42	.	.	.
cord-001835-0s7ok4uw	3608	1	Using	use	VBG
cord-001835-0s7ok4uw	3608	2	CorA	CorA	NNP
cord-001835-0s7ok4uw	3608	3	,	,	,
cord-001835-0s7ok4uw	3608	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3608	5	developed	develop	VBD
cord-001835-0s7ok4uw	3608	6	a	a	DT
cord-001835-0s7ok4uw	3608	7	more	more	RBR
cord-001835-0s7ok4uw	3608	8	sophisticated	sophisticated	JJ
cord-001835-0s7ok4uw	3608	9	sorting	sorting	NN
cord-001835-0s7ok4uw	3608	10	strategy	strategy	NN
cord-001835-0s7ok4uw	3608	11	resulting	result	VBG
cord-001835-0s7ok4uw	3608	12	in	in	IN
cord-001835-0s7ok4uw	3608	13	a	a	DT
cord-001835-0s7ok4uw	3608	14	variety	variety	NN
cord-001835-0s7ok4uw	3608	15	of	of	IN
cord-001835-0s7ok4uw	3608	16	sABs	sabs	NN
cord-001835-0s7ok4uw	3608	17	specific	specific	JJ
cord-001835-0s7ok4uw	3608	18	to	to	IN
cord-001835-0s7ok4uw	3608	19	either	either	CC
cord-001835-0s7ok4uw	3608	20	the	the	DT
cord-001835-0s7ok4uw	3608	21	open	open	JJ
cord-001835-0s7ok4uw	3608	22	or	or	CC
cord-001835-0s7ok4uw	3608	23	closed	closed	JJ
cord-001835-0s7ok4uw	3608	24	conformation	conformation	NN
cord-001835-0s7ok4uw	3608	25	of	of	IN
cord-001835-0s7ok4uw	3608	26	the	the	DT
cord-001835-0s7ok4uw	3608	27	channel	channel	NN
cord-001835-0s7ok4uw	3608	28	.	.	.
cord-001835-0s7ok4uw	3609	1	Finally	finally	RB
cord-001835-0s7ok4uw	3609	2	,	,	,
cord-001835-0s7ok4uw	3609	3	using	use	VBG
cord-001835-0s7ok4uw	3609	4	sABs	sabs	RB
cord-001835-0s7ok4uw	3609	5	as	as	IN
cord-001835-0s7ok4uw	3609	6	crystallization	crystallization	NN
cord-001835-0s7ok4uw	3609	7	chaperones	chaperone	NNS
cord-001835-0s7ok4uw	3609	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	3609	9	obtained	obtain	VBD
cord-001835-0s7ok4uw	3609	10	the	the	DT
cord-001835-0s7ok4uw	3609	11	structure	structure	NN
cord-001835-0s7ok4uw	3609	12	of	of	IN
cord-001835-0s7ok4uw	3609	13	Mj0480	Mj0480	NNP
cord-001835-0s7ok4uw	3609	14	at	at	IN
cord-001835-0s7ok4uw	3609	15	3.5Å	3.5å	NN
cord-001835-0s7ok4uw	3609	16	resolution	resolution	NN
cord-001835-0s7ok4uw	3609	17	,	,	,
cord-001835-0s7ok4uw	3609	18	and	and	CC
cord-001835-0s7ok4uw	3609	19	crystallized	crystallize	VBD
cord-001835-0s7ok4uw	3609	20	CorA	CorA	NNP
cord-001835-0s7ok4uw	3609	21	in	in	IN
cord-001835-0s7ok4uw	3609	22	several	several	JJ
cord-001835-0s7ok4uw	3609	23	new	new	JJ
cord-001835-0s7ok4uw	3609	24	conditions	condition	NNS
cord-001835-0s7ok4uw	3609	25	.	.	.
cord-001835-0s7ok4uw	3609	26	 	 	_SP
cord-001835-0s7ok4uw	3610	1	Lipocalin	lipocalin	NN
cord-001835-0s7ok4uw	3610	2	-	-	HYPH
cord-001835-0s7ok4uw	3610	3	type	type	NN
cord-001835-0s7ok4uw	3610	4	prostaglandin	prostaglandin	NN
cord-001835-0s7ok4uw	3610	5	D	d	NN
cord-001835-0s7ok4uw	3610	6	synthase	synthase	NN
cord-001835-0s7ok4uw	3610	7	(	(	-LRB-
cord-001835-0s7ok4uw	3610	8	L	L	NNP
cord-001835-0s7ok4uw	3610	9	-	-	HYPH
cord-001835-0s7ok4uw	3610	10	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3610	11	)	)	-RRB-
cord-001835-0s7ok4uw	3610	12	is	be	VBZ
cord-001835-0s7ok4uw	3610	13	a	a	DT
cord-001835-0s7ok4uw	3610	14	member	member	NN
cord-001835-0s7ok4uw	3610	15	of	of	IN
cord-001835-0s7ok4uw	3610	16	the	the	DT
cord-001835-0s7ok4uw	3610	17	lipocalin	lipocalin	NNP
cord-001835-0s7ok4uw	3610	18	superfamily	superfamily	NNP
cord-001835-0s7ok4uw	3610	19	,	,	,
cord-001835-0s7ok4uw	3610	20	and	and	CC
cord-001835-0s7ok4uw	3610	21	binds	bind	VBZ
cord-001835-0s7ok4uw	3610	22	a	a	DT
cord-001835-0s7ok4uw	3610	23	large	large	JJ
cord-001835-0s7ok4uw	3610	24	variety	variety	NN
cord-001835-0s7ok4uw	3610	25	of	of	IN
cord-001835-0s7ok4uw	3610	26	small	small	JJ
cord-001835-0s7ok4uw	3610	27	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3610	28	molecules	molecule	NNS
cord-001835-0s7ok4uw	3610	29	.	.	.
cord-001835-0s7ok4uw	3611	1	Using	use	VBG
cord-001835-0s7ok4uw	3611	2	this	this	DT
cord-001835-0s7ok4uw	3611	3	function	function	NN
cord-001835-0s7ok4uw	3611	4	of	of	IN
cord-001835-0s7ok4uw	3611	5	L	L	NNP
cord-001835-0s7ok4uw	3611	6	-	-	HYPH
cord-001835-0s7ok4uw	3611	7	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3611	8	,	,	,
cord-001835-0s7ok4uw	3611	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	3611	10	have	have	VBP
cord-001835-0s7ok4uw	3611	11	already	already	RB
cord-001835-0s7ok4uw	3611	12	reported	report	VBN
cord-001835-0s7ok4uw	3611	13	the	the	DT
cord-001835-0s7ok4uw	3611	14	feasibility	feasibility	NN
cord-001835-0s7ok4uw	3611	15	of	of	IN
cord-001835-0s7ok4uw	3611	16	L	L	NNP
cord-001835-0s7ok4uw	3611	17	-	-	HYPH
cord-001835-0s7ok4uw	3611	18	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3611	19	as	as	IN
cord-001835-0s7ok4uw	3611	20	a	a	DT
cord-001835-0s7ok4uw	3611	21	novel	novel	JJ
cord-001835-0s7ok4uw	3611	22	drug	drug	NN
cord-001835-0s7ok4uw	3611	23	delivery	delivery	NN
cord-001835-0s7ok4uw	3611	24	vehicle	vehicle	NN
cord-001835-0s7ok4uw	3611	25	for	for	IN
cord-001835-0s7ok4uw	3611	26	the	the	DT
cord-001835-0s7ok4uw	3611	27	poorly	poorly	RB
cord-001835-0s7ok4uw	3611	28	water	water	NN
cord-001835-0s7ok4uw	3611	29	-	-	HYPH
cord-001835-0s7ok4uw	3611	30	soluble	soluble	JJ
cord-001835-0s7ok4uw	3611	31	drugs	drug	NNS
cord-001835-0s7ok4uw	3611	32	[	[	-LRB-
cord-001835-0s7ok4uw	3611	33	1	1	CD
cord-001835-0s7ok4uw	3611	34	]	]	-RRB-
cord-001835-0s7ok4uw	3611	35	.	.	.
cord-001835-0s7ok4uw	3612	1	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3612	2	,	,	,
cord-001835-0s7ok4uw	3612	3	7-ethyl-10-hydroxy	7-ethyl-10-hydroxy	NNP
cord-001835-0s7ok4uw	3612	4	-	-	HYPH
cord-001835-0s7ok4uw	3612	5	camptothecin	camptothecin	NNS
cord-001835-0s7ok4uw	3612	6	,	,	,
cord-001835-0s7ok4uw	3612	7	is	be	VBZ
cord-001835-0s7ok4uw	3612	8	a	a	DT
cord-001835-0s7ok4uw	3612	9	semi	semi	JJ
cord-001835-0s7ok4uw	3612	10	-	-	JJ
cord-001835-0s7ok4uw	3612	11	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3612	12	analogue	analogue	NN
cord-001835-0s7ok4uw	3612	13	of	of	IN
cord-001835-0s7ok4uw	3612	14	anti	anti	JJ
cord-001835-0s7ok4uw	3612	15	-	-	JJ
cord-001835-0s7ok4uw	3612	16	cancer	cancer	JJ
cord-001835-0s7ok4uw	3612	17	alkaloid	alkaloid	NN
cord-001835-0s7ok4uw	3612	18	camptothecin	camptothecin	NNS
cord-001835-0s7ok4uw	3612	19	that	that	WDT
cord-001835-0s7ok4uw	3612	20	targets	target	VBZ
cord-001835-0s7ok4uw	3612	21	DNA	DNA	NNP
cord-001835-0s7ok4uw	3613	1	topoisomerase	topoisomerase	NN
cord-001835-0s7ok4uw	3613	2	I.	I.	NNP
cord-001835-0s7ok4uw	3613	3	Despite	Despite	NNP
cord-001835-0s7ok4uw	3613	4	of	of	IN
cord-001835-0s7ok4uw	3613	5	the	the	DT
cord-001835-0s7ok4uw	3613	6	potent	potent	JJ
cord-001835-0s7ok4uw	3613	7	anti	anti	JJ
cord-001835-0s7ok4uw	3613	8	-	-	JJ
cord-001835-0s7ok4uw	3613	9	tumor	tumor	JJ
cord-001835-0s7ok4uw	3613	10	activity	activity	NN
cord-001835-0s7ok4uw	3613	11	,	,	,
cord-001835-0s7ok4uw	3613	12	however	however	RB
cord-001835-0s7ok4uw	3613	13	,	,	,
cord-001835-0s7ok4uw	3613	14	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3613	15	was	be	VBD
cord-001835-0s7ok4uw	3613	16	not	not	RB
cord-001835-0s7ok4uw	3613	17	used	use	VBN
cord-001835-0s7ok4uw	3613	18	directly	directly	RB
cord-001835-0s7ok4uw	3613	19	in	in	IN
cord-001835-0s7ok4uw	3613	20	a	a	DT
cord-001835-0s7ok4uw	3613	21	clinical	clinical	JJ
cord-001835-0s7ok4uw	3613	22	practice	practice	NN
cord-001835-0s7ok4uw	3613	23	due	due	IN
cord-001835-0s7ok4uw	3613	24	to	to	IN
cord-001835-0s7ok4uw	3613	25	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3613	26	poor	poor	JJ
cord-001835-0s7ok4uw	3613	27	water	water	NN
cord-001835-0s7ok4uw	3613	28	solubility	solubility	NN
cord-001835-0s7ok4uw	3613	29	.	.	.
cord-001835-0s7ok4uw	3614	1	Thus	thus	RB
cord-001835-0s7ok4uw	3614	2	,	,	,
cord-001835-0s7ok4uw	3614	3	irinotecan	irinotecan	NNP
cord-001835-0s7ok4uw	3614	4	hydrochloride	hydrochloride	NN
cord-001835-0s7ok4uw	3614	5	(	(	-LRB-
cord-001835-0s7ok4uw	3614	6	CPT-11	CPT-11	NNP
cord-001835-0s7ok4uw	3614	7	)	)	-RRB-
cord-001835-0s7ok4uw	3614	8	,	,	,
cord-001835-0s7ok4uw	3614	9	which	which	WDT
cord-001835-0s7ok4uw	3614	10	is	be	VBZ
cord-001835-0s7ok4uw	3614	11	the	the	DT
cord-001835-0s7ok4uw	3614	12	water	water	NN
cord-001835-0s7ok4uw	3614	13	-	-	HYPH
cord-001835-0s7ok4uw	3614	14	soluble	soluble	JJ
cord-001835-0s7ok4uw	3614	15	prodrug	prodrug	NN
cord-001835-0s7ok4uw	3614	16	of	of	IN
cord-001835-0s7ok4uw	3614	17	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3614	18	,	,	,
cord-001835-0s7ok4uw	3614	19	is	be	VBZ
cord-001835-0s7ok4uw	3614	20	used	use	VBN
cord-001835-0s7ok4uw	3614	21	for	for	IN
cord-001835-0s7ok4uw	3614	22	the	the	DT
cord-001835-0s7ok4uw	3614	23	cancer	cancer	NN
cord-001835-0s7ok4uw	3614	24	treatment	treatment	NN
cord-001835-0s7ok4uw	3614	25	.	.	.
cord-001835-0s7ok4uw	3615	1	However	however	RB
cord-001835-0s7ok4uw	3615	2	,	,	,
cord-001835-0s7ok4uw	3615	3	CPT-11	CPT-11	NNP
cord-001835-0s7ok4uw	3615	4	shows	show	VBZ
cord-001835-0s7ok4uw	3615	5	approximately	approximately	RB
cord-001835-0s7ok4uw	3615	6	0.1	0.1	CD
cord-001835-0s7ok4uw	3615	7	%	%	NN
cord-001835-0s7ok4uw	3615	8	cytotoxic	cytotoxic	JJ
cord-001835-0s7ok4uw	3615	9	activity	activity	NN
cord-001835-0s7ok4uw	3615	10	of	of	IN
cord-001835-0s7ok4uw	3615	11	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3615	12	against	against	IN
cord-001835-0s7ok4uw	3615	13	the	the	DT
cord-001835-0s7ok4uw	3615	14	various	various	JJ
cord-001835-0s7ok4uw	3615	15	cancer	cancer	NN
cord-001835-0s7ok4uw	3615	16	cell	cell	NN
cord-001835-0s7ok4uw	3615	17	lines	line	NNS
cord-001835-0s7ok4uw	3615	18	in	in	IN
cord-001835-0s7ok4uw	3615	19	vitro	vitro	FW
cord-001835-0s7ok4uw	3615	20	,	,	,
cord-001835-0s7ok4uw	3615	21	and	and	CC
cord-001835-0s7ok4uw	3615	22	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3615	23	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	3615	24	conversion	conversion	NN
cord-001835-0s7ok4uw	3615	25	rate	rate	NN
cord-001835-0s7ok4uw	3615	26	is	be	VBZ
cord-001835-0s7ok4uw	3615	27	10	10	CD
cord-001835-0s7ok4uw	3615	28	%	%	NN
cord-001835-0s7ok4uw	3615	29	of	of	IN
cord-001835-0s7ok4uw	3615	30	the	the	DT
cord-001835-0s7ok4uw	3615	31	original	original	JJ
cord-001835-0s7ok4uw	3615	32	volume	volume	NN
cord-001835-0s7ok4uw	3615	33	of	of	IN
cord-001835-0s7ok4uw	3615	34	CPT-11	CPT-11	NNP
cord-001835-0s7ok4uw	3615	35	.	.	.
cord-001835-0s7ok4uw	3616	1	Here	here	RB
cord-001835-0s7ok4uw	3616	2	,	,	,
cord-001835-0s7ok4uw	3616	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3616	4	show	show	VBP
cord-001835-0s7ok4uw	3616	5	the	the	DT
cord-001835-0s7ok4uw	3616	6	development	development	NN
cord-001835-0s7ok4uw	3616	7	of	of	IN
cord-001835-0s7ok4uw	3616	8	the	the	DT
cord-001835-0s7ok4uw	3616	9	drug	drug	NN
cord-001835-0s7ok4uw	3616	10	delivery	delivery	NN
cord-001835-0s7ok4uw	3616	11	system	system	NN
cord-001835-0s7ok4uw	3616	12	utilizing	utilize	VBG
cord-001835-0s7ok4uw	3616	13	L	L	NNP
cord-001835-0s7ok4uw	3616	14	-	-	HYPH
cord-001835-0s7ok4uw	3616	15	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3616	16	,	,	,
cord-001835-0s7ok4uw	3616	17	which	which	WDT
cord-001835-0s7ok4uw	3616	18	enables	enable	VBZ
cord-001835-0s7ok4uw	3616	19	a	a	DT
cord-001835-0s7ok4uw	3616	20	direct	direct	JJ
cord-001835-0s7ok4uw	3616	21	clinical	clinical	JJ
cord-001835-0s7ok4uw	3616	22	usage	usage	NN
cord-001835-0s7ok4uw	3616	23	of	of	IN
cord-001835-0s7ok4uw	3616	24	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3616	25	.	.	.
cord-001835-0s7ok4uw	3617	1	First	first	RB
cord-001835-0s7ok4uw	3617	2	,	,	,
cord-001835-0s7ok4uw	3617	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3617	4	investigated	investigate	VBD
cord-001835-0s7ok4uw	3617	5	the	the	DT
cord-001835-0s7ok4uw	3617	6	effect	effect	NN
cord-001835-0s7ok4uw	3617	7	of	of	IN
cord-001835-0s7ok4uw	3617	8	L	L	NNP
cord-001835-0s7ok4uw	3617	9	-	-	HYPH
cord-001835-0s7ok4uw	3617	10	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3617	11	on	on	IN
cord-001835-0s7ok4uw	3617	12	the	the	DT
cord-001835-0s7ok4uw	3617	13	solubility	solubility	NN
cord-001835-0s7ok4uw	3617	14	of	of	IN
cord-001835-0s7ok4uw	3617	15	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3617	16	.	.	.
cord-001835-0s7ok4uw	3618	1	In	in	IN
cord-001835-0s7ok4uw	3618	2	the	the	DT
cord-001835-0s7ok4uw	3618	3	presence	presence	NN
cord-001835-0s7ok4uw	3618	4	of	of	IN
cord-001835-0s7ok4uw	3618	5	2	2	CD
cord-001835-0s7ok4uw	3618	6	mM	mm	CD
cord-001835-0s7ok4uw	3618	7	L	L	NNP
cord-001835-0s7ok4uw	3618	8	-	-	HYPH
cord-001835-0s7ok4uw	3618	9	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3618	10	,	,	,
cord-001835-0s7ok4uw	3618	11	the	the	DT
cord-001835-0s7ok4uw	3618	12	concentration	concentration	NN
cord-001835-0s7ok4uw	3618	13	of	of	IN
cord-001835-0s7ok4uw	3618	14	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3618	15	was	be	VBD
cord-001835-0s7ok4uw	3618	16	1.7	1.7	CD
cord-001835-0s7ok4uw	3618	17	mM	mm	NN
cord-001835-0s7ok4uw	3618	18	,	,	,
cord-001835-0s7ok4uw	3618	19	which	which	WDT
cord-001835-0s7ok4uw	3618	20	was	be	VBD
cord-001835-0s7ok4uw	3618	21	1,130-fold	1,130-fold	CD
cord-001835-0s7ok4uw	3618	22	as	as	IN
cord-001835-0s7ok4uw	3618	23	compared	compare	VBN
cord-001835-0s7ok4uw	3618	24	with	with	IN
cord-001835-0s7ok4uw	3618	25	that	that	DT
cord-001835-0s7ok4uw	3618	26	in	in	IN
cord-001835-0s7ok4uw	3618	27	PBS	PBS	NNP
cord-001835-0s7ok4uw	3618	28	.	.	.
cord-001835-0s7ok4uw	3619	1	Then	then	RB
cord-001835-0s7ok4uw	3619	2	,	,	,
cord-001835-0s7ok4uw	3619	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3619	4	carried	carry	VBD
cord-001835-0s7ok4uw	3619	5	out	out	RP
cord-001835-0s7ok4uw	3619	6	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	3619	7	titration	titration	NN
cord-001835-0s7ok4uw	3619	8	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	3619	9	measurements	measurement	NNS
cord-001835-0s7ok4uw	3619	10	to	to	TO
cord-001835-0s7ok4uw	3619	11	investigate	investigate	VB
cord-001835-0s7ok4uw	3619	12	the	the	DT
cord-001835-0s7ok4uw	3619	13	detailed	detailed	JJ
cord-001835-0s7ok4uw	3619	14	binding	binding	NN
cord-001835-0s7ok4uw	3619	15	mode	mode	NN
cord-001835-0s7ok4uw	3619	16	of	of	IN
cord-001835-0s7ok4uw	3619	17	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3619	18	to	to	IN
cord-001835-0s7ok4uw	3619	19	L	L	NNP
cord-001835-0s7ok4uw	3619	20	-	-	HYPH
cord-001835-0s7ok4uw	3619	21	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3619	22	.	.	.
cord-001835-0s7ok4uw	3620	1	As	as	IN
cord-001835-0s7ok4uw	3620	2	a	a	DT
cord-001835-0s7ok4uw	3620	3	result	result	NN
cord-001835-0s7ok4uw	3620	4	,	,	,
cord-001835-0s7ok4uw	3620	5	it	-PRON-	PRP
cord-001835-0s7ok4uw	3620	6	was	be	VBD
cord-001835-0s7ok4uw	3620	7	revealed	reveal	VBN
cord-001835-0s7ok4uw	3620	8	that	that	IN
cord-001835-0s7ok4uw	3620	9	L	L	NNP
cord-001835-0s7ok4uw	3620	10	-	-	HYPH
cord-001835-0s7ok4uw	3620	11	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3620	12	binds	bind	VBZ
cord-001835-0s7ok4uw	3620	13	three	three	CD
cord-001835-0s7ok4uw	3620	14	molecules	molecule	NNS
cord-001835-0s7ok4uw	3620	15	of	of	IN
cord-001835-0s7ok4uw	3620	16	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3620	17	,	,	,
cord-001835-0s7ok4uw	3620	18	and	and	CC
cord-001835-0s7ok4uw	3620	19	the	the	DT
cord-001835-0s7ok4uw	3620	20	dissocia-	dissocia-	JJ
cord-001835-0s7ok4uw	3620	21	Control	Control	NNP
cord-001835-0s7ok4uw	3620	22	over	over	IN
cord-001835-0s7ok4uw	3620	23	the	the	DT
cord-001835-0s7ok4uw	3620	24	sensitivity	sensitivity	NN
cord-001835-0s7ok4uw	3620	25	with	with	IN
cord-001835-0s7ok4uw	3620	26	which	which	WDT
cord-001835-0s7ok4uw	3620	27	artificial	artificial	JJ
cord-001835-0s7ok4uw	3620	28	biomolecular	biomolecular	JJ
cord-001835-0s7ok4uw	3620	29	receptors	receptor	NNS
cord-001835-0s7ok4uw	3620	30	respond	respond	VBP
cord-001835-0s7ok4uw	3620	31	to	to	IN
cord-001835-0s7ok4uw	3620	32	small	small	JJ
cord-001835-0s7ok4uw	3620	33	changes	change	NNS
cord-001835-0s7ok4uw	3620	34	in	in	IN
cord-001835-0s7ok4uw	3620	35	the	the	DT
cord-001835-0s7ok4uw	3620	36	concentration	concentration	NN
cord-001835-0s7ok4uw	3620	37	of	of	IN
cord-001835-0s7ok4uw	3620	38	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3620	39	target	target	NN
cord-001835-0s7ok4uw	3620	40	ligand	ligand	NN
cord-001835-0s7ok4uw	3620	41	is	be	VBZ
cord-001835-0s7ok4uw	3620	42	critical	critical	JJ
cord-001835-0s7ok4uw	3620	43	for	for	IN
cord-001835-0s7ok4uw	3620	44	the	the	DT
cord-001835-0s7ok4uw	3620	45	proper	proper	JJ
cord-001835-0s7ok4uw	3620	46	function	function	NN
cord-001835-0s7ok4uw	3620	47	of	of	IN
cord-001835-0s7ok4uw	3620	48	many	many	JJ
cord-001835-0s7ok4uw	3620	49	cellular	cellular	JJ
cord-001835-0s7ok4uw	3620	50	processes	process	NNS
cord-001835-0s7ok4uw	3620	51	.	.	.
cord-001835-0s7ok4uw	3621	1	Such	such	JJ
cord-001835-0s7ok4uw	3621	2	control	control	NN
cord-001835-0s7ok4uw	3621	3	could	could	MD
cord-001835-0s7ok4uw	3621	4	likewise	likewise	RB
cord-001835-0s7ok4uw	3621	5	be	be	VB
cord-001835-0s7ok4uw	3621	6	highly	highly	RB
cord-001835-0s7ok4uw	3621	7	useful	useful	JJ
cord-001835-0s7ok4uw	3621	8	in	in	IN
cord-001835-0s7ok4uw	3621	9	artificial	artificial	JJ
cord-001835-0s7ok4uw	3621	10	biotechnologies	biotechnology	NNS
cord-001835-0s7ok4uw	3621	11	in	in	IN
cord-001835-0s7ok4uw	3621	12	which	which	WDT
cord-001835-0s7ok4uw	3621	13	highly	highly	RB
cord-001835-0s7ok4uw	3621	14	responsive	responsive	JJ
cord-001835-0s7ok4uw	3621	15	behavior	behavior	NN
cord-001835-0s7ok4uw	3621	16	is	be	VBZ
cord-001835-0s7ok4uw	3621	17	of	of	IN
cord-001835-0s7ok4uw	3621	18	value	value	NN
cord-001835-0s7ok4uw	3621	19	,	,	,
cord-001835-0s7ok4uw	3621	20	such	such	JJ
cord-001835-0s7ok4uw	3621	21	as	as	IN
cord-001835-0s7ok4uw	3621	22	biosensors	biosensor	NNS
cord-001835-0s7ok4uw	3621	23	,	,	,
cord-001835-0s7ok4uw	3621	24	genetic	genetic	JJ
cord-001835-0s7ok4uw	3621	25	logic	logic	NN
cord-001835-0s7ok4uw	3621	26	gates	gate	NNS
cord-001835-0s7ok4uw	3621	27	,	,	,
cord-001835-0s7ok4uw	3621	28	and	and	CC
cord-001835-0s7ok4uw	3621	29	"	"	``
cord-001835-0s7ok4uw	3621	30	smart	smart	JJ
cord-001835-0s7ok4uw	3621	31	"	"	''
cord-001835-0s7ok4uw	3621	32	materials	material	NNS
cord-001835-0s7ok4uw	3621	33	and	and	CC
cord-001835-0s7ok4uw	3621	34	delivery	delivery	NN
cord-001835-0s7ok4uw	3621	35	devices	device	NNS
cord-001835-0s7ok4uw	3621	36	.	.	.
cord-001835-0s7ok4uw	3622	1	In	in	IN
cord-001835-0s7ok4uw	3622	2	nature	nature	NN
cord-001835-0s7ok4uw	3622	3	,	,	,
cord-001835-0s7ok4uw	3622	4	the	the	DT
cord-001835-0s7ok4uw	3622	5	control	control	NN
cord-001835-0s7ok4uw	3622	6	of	of	IN
cord-001835-0s7ok4uw	3622	7	molecular	molecular	JJ
cord-001835-0s7ok4uw	3622	8	responsiveness	responsiveness	NN
cord-001835-0s7ok4uw	3622	9	is	be	VBZ
cord-001835-0s7ok4uw	3622	10	often	often	RB
cord-001835-0s7ok4uw	3622	11	achieved	achieve	VBN
cord-001835-0s7ok4uw	3622	12	using	use	VBG
cord-001835-0s7ok4uw	3622	13	"	"	``
cord-001835-0s7ok4uw	3622	14	Hill	hill	NN
cord-001835-0s7ok4uw	3622	15	-	-	HYPH
cord-001835-0s7ok4uw	3622	16	type	type	NN
cord-001835-0s7ok4uw	3622	17	"	"	''
cord-001835-0s7ok4uw	3622	18	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	3622	19	,	,	,
cord-001835-0s7ok4uw	3622	20	a	a	DT
cord-001835-0s7ok4uw	3622	21	mechanism	mechanism	NN
cord-001835-0s7ok4uw	3622	22	in	in	IN
cord-001835-0s7ok4uw	3622	23	which	which	WDT
cord-001835-0s7ok4uw	3622	24	sequential	sequential	JJ
cord-001835-0s7ok4uw	3622	25	binding	bind	VBG
cord-001835-0s7ok4uw	3622	26	events	event	NNS
cord-001835-0s7ok4uw	3622	27	on	on	IN
cord-001835-0s7ok4uw	3622	28	a	a	DT
cord-001835-0s7ok4uw	3622	29	multivalent	multivalent	JJ
cord-001835-0s7ok4uw	3622	30	receptor	receptor	NN
cord-001835-0s7ok4uw	3622	31	are	be	VBP
cord-001835-0s7ok4uw	3622	32	coupled	couple	VBN
cord-001835-0s7ok4uw	3622	33	such	such	JJ
cord-001835-0s7ok4uw	3622	34	that	that	IN
cord-001835-0s7ok4uw	3622	35	the	the	DT
cord-001835-0s7ok4uw	3622	36	first	first	JJ
cord-001835-0s7ok4uw	3622	37	enhances	enhance	VBZ
cord-001835-0s7ok4uw	3622	38	the	the	DT
cord-001835-0s7ok4uw	3622	39	affinity	affinity	NN
cord-001835-0s7ok4uw	3622	40	of	of	IN
cord-001835-0s7ok4uw	3622	41	the	the	DT
cord-001835-0s7ok4uw	3622	42	next	next	JJ
cord-001835-0s7ok4uw	3622	43	,	,	,
cord-001835-0s7ok4uw	3622	44	producing	produce	VBG
cord-001835-0s7ok4uw	3622	45	a	a	DT
cord-001835-0s7ok4uw	3622	46	steep	steep	JJ
cord-001835-0s7ok4uw	3622	47	,	,	,
cord-001835-0s7ok4uw	3622	48	higher	high	JJR
cord-001835-0s7ok4uw	3622	49	-	-	HYPH
cord-001835-0s7ok4uw	3622	50	order	order	NN
cord-001835-0s7ok4uw	3622	51	dependence	dependence	NN
cord-001835-0s7ok4uw	3622	52	on	on	IN
cord-001835-0s7ok4uw	3622	53	target	target	NN
cord-001835-0s7ok4uw	3622	54	concentration	concentration	NN
cord-001835-0s7ok4uw	3622	55	.	.	.
cord-001835-0s7ok4uw	3623	1	Here	here	RB
cord-001835-0s7ok4uw	3623	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3623	3	use	use	VBP
cord-001835-0s7ok4uw	3623	4	an	an	DT
cord-001835-0s7ok4uw	3623	5	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	3623	6	-	-	HYPH
cord-001835-0s7ok4uw	3623	7	disorder	disorder	NN
cord-001835-0s7ok4uw	3623	8	-	-	HYPH
cord-001835-0s7ok4uw	3623	9	based	base	VBN
cord-001835-0s7ok4uw	3623	10	mechanism	mechanism	NN
cord-001835-0s7ok4uw	3623	11	that	that	WDT
cord-001835-0s7ok4uw	3623	12	can	can	MD
cord-001835-0s7ok4uw	3623	13	be	be	VB
cord-001835-0s7ok4uw	3623	14	implemented	implement	VBN
cord-001835-0s7ok4uw	3623	15	without	without	IN
cord-001835-0s7ok4uw	3623	16	requiring	require	VBG
cord-001835-0s7ok4uw	3623	17	detailed	detailed	JJ
cord-001835-0s7ok4uw	3623	18	structural	structural	JJ
cord-001835-0s7ok4uw	3623	19	knowledge	knowledge	NN
cord-001835-0s7ok4uw	3623	20	to	to	TO
cord-001835-0s7ok4uw	3623	21	rationally	rationally	RB
cord-001835-0s7ok4uw	3623	22	introduce	introduce	VB
cord-001835-0s7ok4uw	3623	23	this	this	DT
cord-001835-0s7ok4uw	3623	24	potentially	potentially	RB
cord-001835-0s7ok4uw	3623	25	useful	useful	JJ
cord-001835-0s7ok4uw	3623	26	property	property	NN
cord-001835-0s7ok4uw	3623	27	into	into	IN
cord-001835-0s7ok4uw	3623	28	several	several	JJ
cord-001835-0s7ok4uw	3623	29	normally	normally	RB
cord-001835-0s7ok4uw	3623	30	noncooperative	noncooperative	JJ
cord-001835-0s7ok4uw	3623	31	biomolecules	biomolecule	NNS
cord-001835-0s7ok4uw	3623	32	.	.	.
cord-001835-0s7ok4uw	3624	1	To	to	TO
cord-001835-0s7ok4uw	3624	2	do	do	VB
cord-001835-0s7ok4uw	3624	3	so	so	RB
cord-001835-0s7ok4uw	3624	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3624	5	fabricate	fabricate	VBP
cord-001835-0s7ok4uw	3624	6	a	a	DT
cord-001835-0s7ok4uw	3624	7	tandem	tandem	JJ
cord-001835-0s7ok4uw	3624	8	repeat	repeat	NN
cord-001835-0s7ok4uw	3624	9	of	of	IN
cord-001835-0s7ok4uw	3624	10	the	the	DT
cord-001835-0s7ok4uw	3624	11	receptor	receptor	NN
cord-001835-0s7ok4uw	3624	12	that	that	WDT
cord-001835-0s7ok4uw	3624	13	is	be	VBZ
cord-001835-0s7ok4uw	3624	14	destabilized	destabilize	VBN
cord-001835-0s7ok4uw	3624	15	(	(	-LRB-
cord-001835-0s7ok4uw	3624	16	unfolded	unfold	VBN
cord-001835-0s7ok4uw	3624	17	)	)	-RRB-
cord-001835-0s7ok4uw	3624	18	via	via	IN
cord-001835-0s7ok4uw	3624	19	the	the	DT
cord-001835-0s7ok4uw	3624	20	introduction	introduction	NN
cord-001835-0s7ok4uw	3624	21	of	of	IN
cord-001835-0s7ok4uw	3624	22	a	a	DT
cord-001835-0s7ok4uw	3624	23	long	long	JJ
cord-001835-0s7ok4uw	3624	24	,	,	,
cord-001835-0s7ok4uw	3624	25	unstructured	unstructured	JJ
cord-001835-0s7ok4uw	3624	26	loop	loop	NN
cord-001835-0s7ok4uw	3624	27	.	.	.
cord-001835-0s7ok4uw	3625	1	The	the	DT
cord-001835-0s7ok4uw	3625	2	loop	loop	NN
cord-001835-0s7ok4uw	3625	3	spatially	spatially	RB
cord-001835-0s7ok4uw	3625	4	separates	separate	VBZ
cord-001835-0s7ok4uw	3625	5	the	the	DT
cord-001835-0s7ok4uw	3625	6	two	two	CD
cord-001835-0s7ok4uw	3625	7	sets	set	NNS
cord-001835-0s7ok4uw	3625	8	of	of	IN
cord-001835-0s7ok4uw	3625	9	the	the	DT
cord-001835-0s7ok4uw	3625	10	two	two	CD
cord-001835-0s7ok4uw	3625	11	halves	half	NNS
cord-001835-0s7ok4uw	3625	12	of	of	IN
cord-001835-0s7ok4uw	3625	13	the	the	DT
cord-001835-0s7ok4uw	3625	14	binding	bind	VBG
cord-001835-0s7ok4uw	3625	15	sites	site	NNS
cord-001835-0s7ok4uw	3625	16	,	,	,
cord-001835-0s7ok4uw	3625	17	preventing	prevent	VBG
cord-001835-0s7ok4uw	3625	18	a	a	DT
cord-001835-0s7ok4uw	3625	19	complete	complete	JJ
cord-001835-0s7ok4uw	3625	20	binding	binding	NN
cord-001835-0s7ok4uw	3625	21	site	site	NN
cord-001835-0s7ok4uw	3625	22	that	that	WDT
cord-001835-0s7ok4uw	3625	23	enables	enable	VBZ
cord-001835-0s7ok4uw	3625	24	target	target	NN
cord-001835-0s7ok4uw	3625	25	molecule	molecule	NN
cord-001835-0s7ok4uw	3625	26	binding	bind	VBG
cord-001835-0s7ok4uw	3625	27	without	without	IN
cord-001835-0s7ok4uw	3625	28	prior	prior	JJ
cord-001835-0s7ok4uw	3625	29	closure	closure	NN
cord-001835-0s7ok4uw	3625	30	of	of	IN
cord-001835-0s7ok4uw	3625	31	the	the	DT
cord-001835-0s7ok4uw	3625	32	loop	loop	NN
cord-001835-0s7ok4uw	3625	33	.	.	.
cord-001835-0s7ok4uw	3626	1	Thus	thus	RB
cord-001835-0s7ok4uw	3626	2	,	,	,
cord-001835-0s7ok4uw	3626	3	the	the	DT
cord-001835-0s7ok4uw	3626	4	first	first	JJ
cord-001835-0s7ok4uw	3626	5	binding	bind	VBG
cord-001835-0s7ok4uw	3626	6	event	event	NN
cord-001835-0s7ok4uw	3626	7	requires	require	VBZ
cord-001835-0s7ok4uw	3626	8	the	the	DT
cord-001835-0s7ok4uw	3626	9	energetically	energetically	RB
cord-001835-0s7ok4uw	3626	10	unfavorable	unfavorable	JJ
cord-001835-0s7ok4uw	3626	11	closing	closing	NN
cord-001835-0s7ok4uw	3626	12	of	of	IN
cord-001835-0s7ok4uw	3626	13	this	this	DT
cord-001835-0s7ok4uw	3626	14	loop	loop	NN
cord-001835-0s7ok4uw	3626	15	,	,	,
cord-001835-0s7ok4uw	3626	16	reducing	reduce	VBG
cord-001835-0s7ok4uw	3626	17	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3626	18	affinity	affinity	NN
cord-001835-0s7ok4uw	3626	19	relative	relative	NN
cord-001835-0s7ok4uw	3626	20	to	to	IN
cord-001835-0s7ok4uw	3626	21	that	that	DT
cord-001835-0s7ok4uw	3626	22	of	of	IN
cord-001835-0s7ok4uw	3626	23	the	the	DT
cord-001835-0s7ok4uw	3626	24	second	second	JJ
cord-001835-0s7ok4uw	3626	25	binding	binding	NN
cord-001835-0s7ok4uw	3626	26	event	event	NN
cord-001835-0s7ok4uw	3626	27	,	,	,
cord-001835-0s7ok4uw	3626	28	which	which	WDT
cord-001835-0s7ok4uw	3626	29	,	,	,
cord-001835-0s7ok4uw	3626	30	in	in	IN
cord-001835-0s7ok4uw	3626	31	contrast	contrast	NN
cord-001835-0s7ok4uw	3626	32	occurs	occur	VBZ
cord-001835-0s7ok4uw	3626	33	at	at	IN
cord-001835-0s7ok4uw	3626	34	a	a	DT
cord-001835-0s7ok4uw	3626	35	pre	pre	JJ
cord-001835-0s7ok4uw	3626	36	-	-	JJ
cord-001835-0s7ok4uw	3626	37	formed	form	VBN
cord-001835-0s7ok4uw	3626	38	site	site	NN
cord-001835-0s7ok4uw	3626	39	.	.	.
cord-001835-0s7ok4uw	3627	1	Using	use	VBG
cord-001835-0s7ok4uw	3627	2	this	this	DT
cord-001835-0s7ok4uw	3627	3	approach	approach	NN
cord-001835-0s7ok4uw	3627	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3627	5	have	have	VBP
cord-001835-0s7ok4uw	3627	6	rationally	rationally	RB
cord-001835-0s7ok4uw	3627	7	introduced	introduce	VBN
cord-001835-0s7ok4uw	3627	8	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	3627	9	into	into	IN
cord-001835-0s7ok4uw	3627	10	three	three	CD
cord-001835-0s7ok4uw	3627	11	unrelated	unrelated	JJ
cord-001835-0s7ok4uw	3627	12	aptamers	aptamer	NNS
cord-001835-0s7ok4uw	3627	13	,	,	,
cord-001835-0s7ok4uw	3627	14	achieving	achieve	VBG
cord-001835-0s7ok4uw	3627	15	in	in	IN
cord-001835-0s7ok4uw	3627	16	the	the	DT
cord-001835-0s7ok4uw	3627	17	best	good	JJS
cord-001835-0s7ok4uw	3627	18	of	of	IN
cord-001835-0s7ok4uw	3627	19	these	these	DT
cord-001835-0s7ok4uw	3627	20	a	a	DT
cord-001835-0s7ok4uw	3627	21	Hill	Hill	NNP
cord-001835-0s7ok4uw	3627	22	coefficient	coefficient	NN
cord-001835-0s7ok4uw	3627	23	experimentally	experimentally	RB
cord-001835-0s7ok4uw	3627	24	indistinguishable	indistinguishable	JJ
cord-001835-0s7ok4uw	3627	25	from	from	IN
cord-001835-0s7ok4uw	3627	26	the	the	DT
cord-001835-0s7ok4uw	3627	27	theoretically	theoretically	RB
cord-001835-0s7ok4uw	3627	28	expected	expect	VBN
cord-001835-0s7ok4uw	3627	29	maximum	maximum	NN
cord-001835-0s7ok4uw	3627	30	.	.	.
cord-001835-0s7ok4uw	3628	1	The	the	DT
cord-001835-0s7ok4uw	3628	2	extent	extent	NN
cord-001835-0s7ok4uw	3628	3	of	of	IN
cord-001835-0s7ok4uw	3628	4	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	3628	5	,	,	,
cord-001835-0s7ok4uw	3628	6	and	and	CC
cord-001835-0s7ok4uw	3628	7	thus	thus	RB
cord-001835-0s7ok4uw	3628	8	the	the	DT
cord-001835-0s7ok4uw	3628	9	steepness	steepness	NN
cord-001835-0s7ok4uw	3628	10	of	of	IN
cord-001835-0s7ok4uw	3628	11	the	the	DT
cord-001835-0s7ok4uw	3628	12	binding	binding	NN
cord-001835-0s7ok4uw	3628	13	transition	transition	NN
cord-001835-0s7ok4uw	3628	14	,	,	,
cord-001835-0s7ok4uw	3628	15	are	be	VBP
cord-001835-0s7ok4uw	3628	16	,	,	,
cord-001835-0s7ok4uw	3628	17	moreover	moreover	RB
cord-001835-0s7ok4uw	3628	18	,	,	,
cord-001835-0s7ok4uw	3628	19	well	well	RB
cord-001835-0s7ok4uw	3628	20	modeled	model	VBN
cord-001835-0s7ok4uw	3628	21	as	as	IN
cord-001835-0s7ok4uw	3628	22	simple	simple	JJ
cord-001835-0s7ok4uw	3628	23	functions	function	NNS
cord-001835-0s7ok4uw	3628	24	of	of	IN
cord-001835-0s7ok4uw	3628	25	the	the	DT
cord-001835-0s7ok4uw	3628	26	energetic	energetic	JJ
cord-001835-0s7ok4uw	3628	27	cost	cost	NN
cord-001835-0s7ok4uw	3628	28	of	of	IN
cord-001835-0s7ok4uw	3628	29	binding	bind	VBG
cord-001835-0s7ok4uw	3628	30	-	-	HYPH
cord-001835-0s7ok4uw	3628	31	induced	induce	VBN
cord-001835-0s7ok4uw	3628	32	folding	folding	NN
cord-001835-0s7ok4uw	3628	33	,	,	,
cord-001835-0s7ok4uw	3628	34	speaking	speak	VBG
cord-001835-0s7ok4uw	3628	35	to	to	IN
cord-001835-0s7ok4uw	3628	36	the	the	DT
cord-001835-0s7ok4uw	3628	37	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	3628	38	nature	nature	NN
cord-001835-0s7ok4uw	3628	39	of	of	IN
cord-001835-0s7ok4uw	3628	40	this	this	DT
cord-001835-0s7ok4uw	3628	41	design	design	NN
cord-001835-0s7ok4uw	3628	42	strategy	strategy	NN
cord-001835-0s7ok4uw	3628	43	.	.	.
cord-001835-0s7ok4uw	3629	1	Essential	essential	JJ
cord-001835-0s7ok4uw	3629	2	and	and	CC
cord-001835-0s7ok4uw	3629	3	non	non	JJ
cord-001835-0s7ok4uw	3629	4	-	-	JJ
cord-001835-0s7ok4uw	3629	5	essential	essential	JJ
cord-001835-0s7ok4uw	3629	6	amino	amino	NN
cord-001835-0s7ok4uw	3629	7	acid	acid	NN
cord-001835-0s7ok4uw	3629	8	species	specie	NNS
cord-001835-0s7ok4uw	3629	9	for	for	IN
cord-001835-0s7ok4uw	3629	10	an	an	DT
cord-001835-0s7ok4uw	3629	11	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	3629	12	protein	protein	NN
cord-001835-0s7ok4uw	3629	13	Satoshi	Satoshi	NNP
cord-001835-0s7ok4uw	3629	14	Akanuma	Akanuma	NNP
cord-001835-0s7ok4uw	3629	15	1	1	CD
cord-001835-0s7ok4uw	3629	16	1	1	CD
cord-001835-0s7ok4uw	3630	1	The	the	DT
cord-001835-0s7ok4uw	3630	2	translation	translation	NN
cord-001835-0s7ok4uw	3630	3	system	system	NN
cord-001835-0s7ok4uw	3630	4	is	be	VBZ
cord-001835-0s7ok4uw	3630	5	an	an	DT
cord-001835-0s7ok4uw	3630	6	essential	essential	JJ
cord-001835-0s7ok4uw	3630	7	element	element	NN
cord-001835-0s7ok4uw	3630	8	for	for	IN
cord-001835-0s7ok4uw	3630	9	life	life	NN
cord-001835-0s7ok4uw	3630	10	because	because	IN
cord-001835-0s7ok4uw	3630	11	it	-PRON-	PRP
cord-001835-0s7ok4uw	3630	12	links	link	VBZ
cord-001835-0s7ok4uw	3630	13	genetic	genetic	JJ
cord-001835-0s7ok4uw	3630	14	information	information	NN
cord-001835-0s7ok4uw	3630	15	embedded	embed	VBN
cord-001835-0s7ok4uw	3630	16	in	in	IN
cord-001835-0s7ok4uw	3630	17	genes	gene	NNS
cord-001835-0s7ok4uw	3630	18	to	to	IN
cord-001835-0s7ok4uw	3630	19	functional	functional	JJ
cord-001835-0s7ok4uw	3630	20	molecules	molecule	NNS
cord-001835-0s7ok4uw	3630	21	,	,	,
cord-001835-0s7ok4uw	3630	22	proteins	protein	NNS
cord-001835-0s7ok4uw	3630	23	.	.	.
cord-001835-0s7ok4uw	3631	1	The	the	DT
cord-001835-0s7ok4uw	3631	2	modern	modern	JJ
cord-001835-0s7ok4uw	3631	3	genetic	genetic	JJ
cord-001835-0s7ok4uw	3631	4	code	code	NN
cord-001835-0s7ok4uw	3631	5	,	,	,
cord-001835-0s7ok4uw	3631	6	which	which	WDT
cord-001835-0s7ok4uw	3631	7	encodes	encode	VBZ
cord-001835-0s7ok4uw	3631	8	the	the	DT
cord-001835-0s7ok4uw	3631	9	standard	standard	JJ
cord-001835-0s7ok4uw	3631	10	20	20	CD
cord-001835-0s7ok4uw	3631	11	amino	amino	NN
cord-001835-0s7ok4uw	3631	12	acids	acid	NNS
cord-001835-0s7ok4uw	3631	13	(	(	-LRB-
cord-001835-0s7ok4uw	3631	14	and	and	CC
cord-001835-0s7ok4uw	3631	15	three	three	CD
cord-001835-0s7ok4uw	3631	16	terminations	termination	NNS
cord-001835-0s7ok4uw	3631	17	)	)	-RRB-
cord-001835-0s7ok4uw	3631	18	using	use	VBG
cord-001835-0s7ok4uw	3631	19	64	64	CD
cord-001835-0s7ok4uw	3631	20	triplet	triplet	NN
cord-001835-0s7ok4uw	3631	21	codons	codon	NNS
cord-001835-0s7ok4uw	3631	22	,	,	,
cord-001835-0s7ok4uw	3631	23	is	be	VBZ
cord-001835-0s7ok4uw	3631	24	shared	share	VBN
cord-001835-0s7ok4uw	3631	25	by	by	IN
cord-001835-0s7ok4uw	3631	26	most	most	JJS
cord-001835-0s7ok4uw	3631	27	of	of	IN
cord-001835-0s7ok4uw	3631	28	the	the	DT
cord-001835-0s7ok4uw	3631	29	extant	extant	JJ
cord-001835-0s7ok4uw	3631	30	organisms	organism	NNS
cord-001835-0s7ok4uw	3631	31	on	on	IN
cord-001835-0s7ok4uw	3631	32	the	the	DT
cord-001835-0s7ok4uw	3631	33	earth	earth	NN
cord-001835-0s7ok4uw	3631	34	.	.	.
cord-001835-0s7ok4uw	3632	1	A	a	DT
cord-001835-0s7ok4uw	3632	2	number	number	NN
cord-001835-0s7ok4uw	3632	3	of	of	IN
cord-001835-0s7ok4uw	3632	4	theories	theory	NNS
cord-001835-0s7ok4uw	3632	5	have	have	VBP
cord-001835-0s7ok4uw	3632	6	been	be	VBN
cord-001835-0s7ok4uw	3632	7	proposed	propose	VBN
cord-001835-0s7ok4uw	3632	8	for	for	IN
cord-001835-0s7ok4uw	3632	9	the	the	DT
cord-001835-0s7ok4uw	3632	10	origin	origin	NN
cord-001835-0s7ok4uw	3632	11	and	and	CC
cord-001835-0s7ok4uw	3632	12	evolution	evolution	NN
cord-001835-0s7ok4uw	3632	13	of	of	IN
cord-001835-0s7ok4uw	3632	14	the	the	DT
cord-001835-0s7ok4uw	3632	15	genetic	genetic	JJ
cord-001835-0s7ok4uw	3632	16	code	code	NN
cord-001835-0s7ok4uw	3632	17	,	,	,
cord-001835-0s7ok4uw	3632	18	and	and	CC
cord-001835-0s7ok4uw	3632	19	these	these	DT
cord-001835-0s7ok4uw	3632	20	theories	theory	NNS
cord-001835-0s7ok4uw	3632	21	suggest	suggest	VBP
cord-001835-0s7ok4uw	3632	22	that	that	IN
cord-001835-0s7ok4uw	3632	23	only	only	RB
cord-001835-0s7ok4uw	3632	24	a	a	DT
cord-001835-0s7ok4uw	3632	25	fewer	few	JJR
cord-001835-0s7ok4uw	3632	26	amino	amino	JJ
cord-001835-0s7ok4uw	3632	27	acids	acid	NNS
cord-001835-0s7ok4uw	3632	28	were	be	VBD
cord-001835-0s7ok4uw	3632	29	used	use	VBN
cord-001835-0s7ok4uw	3632	30	in	in	IN
cord-001835-0s7ok4uw	3632	31	primitive	primitive	JJ
cord-001835-0s7ok4uw	3632	32	proteins	protein	NNS
cord-001835-0s7ok4uw	3632	33	and	and	CC
cord-001835-0s7ok4uw	3632	34	later	later	RBR
cord-001835-0s7ok4uw	3632	35	the	the	DT
cord-001835-0s7ok4uw	3632	36	amino	amino	NN
cord-001835-0s7ok4uw	3632	37	acid	acid	NN
cord-001835-0s7ok4uw	3632	38	repertoire	repertoire	NN
cord-001835-0s7ok4uw	3632	39	gradually	gradually	RB
cord-001835-0s7ok4uw	3632	40	increased	increase	VBD
cord-001835-0s7ok4uw	3632	41	up	up	RB
cord-001835-0s7ok4uw	3632	42	to	to	TO
cord-001835-0s7ok4uw	3632	43	20	20	CD
cord-001835-0s7ok4uw	3632	44	through	through	IN
cord-001835-0s7ok4uw	3632	45	the	the	DT
cord-001835-0s7ok4uw	3632	46	course	course	NN
cord-001835-0s7ok4uw	3632	47	of	of	IN
cord-001835-0s7ok4uw	3632	48	evolution	evolution	NN
cord-001835-0s7ok4uw	3632	49	.	.	.
cord-001835-0s7ok4uw	3633	1	If	if	IN
cord-001835-0s7ok4uw	3633	2	so	so	RB
cord-001835-0s7ok4uw	3633	3	,	,	,
cord-001835-0s7ok4uw	3633	4	one	one	PRP
cord-001835-0s7ok4uw	3633	5	would	would	MD
cord-001835-0s7ok4uw	3633	6	wonder	wonder	VB
cord-001835-0s7ok4uw	3633	7	how	how	WRB
cord-001835-0s7ok4uw	3633	8	many	many	JJ
cord-001835-0s7ok4uw	3633	9	number	number	NN
cord-001835-0s7ok4uw	3633	10	of	of	IN
cord-001835-0s7ok4uw	3633	11	and	and	CC
cord-001835-0s7ok4uw	3633	12	which	which	WDT
cord-001835-0s7ok4uw	3633	13	types	type	NNS
cord-001835-0s7ok4uw	3633	14	of	of	IN
cord-001835-0s7ok4uw	3633	15	amino	amino	NN
cord-001835-0s7ok4uw	3633	16	acids	acid	NNS
cord-001835-0s7ok4uw	3633	17	were	be	VBD
cord-001835-0s7ok4uw	3633	18	involved	involve	VBN
cord-001835-0s7ok4uw	3633	19	in	in	IN
cord-001835-0s7ok4uw	3633	20	the	the	DT
cord-001835-0s7ok4uw	3633	21	primitive	primitive	JJ
cord-001835-0s7ok4uw	3633	22	proteins	protein	NNS
cord-001835-0s7ok4uw	3633	23	.	.	.
cord-001835-0s7ok4uw	3634	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	3634	2	have	have	VBP
cord-001835-0s7ok4uw	3634	3	begun	begin	VBN
cord-001835-0s7ok4uw	3634	4	to	to	TO
cord-001835-0s7ok4uw	3634	5	address	address	VB
cord-001835-0s7ok4uw	3634	6	this	this	DT
cord-001835-0s7ok4uw	3634	7	issue	issue	NN
cord-001835-0s7ok4uw	3634	8	experimentally	experimentally	RB
cord-001835-0s7ok4uw	3634	9	.	.	.
cord-001835-0s7ok4uw	3635	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	3635	2	first	first	RB
cord-001835-0s7ok4uw	3635	3	resurrected	resurrect	VBD
cord-001835-0s7ok4uw	3635	4	several	several	JJ
cord-001835-0s7ok4uw	3635	5	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	3635	6	proteins	protein	NNS
cord-001835-0s7ok4uw	3635	7	and	and	CC
cord-001835-0s7ok4uw	3635	8	then	then	RB
cord-001835-0s7ok4uw	3635	9	restricted	restrict	VBD
cord-001835-0s7ok4uw	3635	10	the	the	DT
cord-001835-0s7ok4uw	3635	11	amino	amino	NN
cord-001835-0s7ok4uw	3635	12	acid	acid	NN
cord-001835-0s7ok4uw	3635	13	usage	usage	NN
cord-001835-0s7ok4uw	3635	14	of	of	IN
cord-001835-0s7ok4uw	3635	15	one	one	CD
cord-001835-0s7ok4uw	3635	16	of	of	IN
cord-001835-0s7ok4uw	3635	17	the	the	DT
cord-001835-0s7ok4uw	3635	18	resurrected	resurrect	VBN
cord-001835-0s7ok4uw	3635	19	proteins	protein	NNS
cord-001835-0s7ok4uw	3635	20	.	.	.
cord-001835-0s7ok4uw	3636	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	3636	2	targeted	target	VBD
cord-001835-0s7ok4uw	3636	3	nucleoside	nucleoside	NN
cord-001835-0s7ok4uw	3636	4	diphosphate	diphosphate	NN
cord-001835-0s7ok4uw	3636	5	kinase	kinase	NN
cord-001835-0s7ok4uw	3636	6	(	(	-LRB-
cord-001835-0s7ok4uw	3636	7	NDK	NDK	NNP
cord-001835-0s7ok4uw	3636	8	)	)	-RRB-
cord-001835-0s7ok4uw	3636	9	that	that	WDT
cord-001835-0s7ok4uw	3636	10	catalyzes	catalyze	VBZ
cord-001835-0s7ok4uw	3636	11	the	the	DT
cord-001835-0s7ok4uw	3636	12	transfer	transfer	NN
cord-001835-0s7ok4uw	3636	13	of	of	IN
cord-001835-0s7ok4uw	3636	14	a	a	DT
cord-001835-0s7ok4uw	3636	15	phosphate	phosphate	NN
cord-001835-0s7ok4uw	3636	16	from	from	IN
cord-001835-0s7ok4uw	3636	17	a	a	DT
cord-001835-0s7ok4uw	3636	18	nucleoside	nucleoside	NN
cord-001835-0s7ok4uw	3636	19	triphosphate	triphosphate	NN
cord-001835-0s7ok4uw	3636	20	to	to	IN
cord-001835-0s7ok4uw	3636	21	a	a	DT
cord-001835-0s7ok4uw	3636	22	nucleoside	nucleoside	NN
cord-001835-0s7ok4uw	3636	23	diphosphate	diphosphate	NN
cord-001835-0s7ok4uw	3636	24	.	.	.
cord-001835-0s7ok4uw	3637	1	NDK	NDK	NNP
cord-001835-0s7ok4uw	3637	2	may	may	MD
cord-001835-0s7ok4uw	3637	3	have	have	VB
cord-001835-0s7ok4uw	3637	4	arisen	arise	VBN
cord-001835-0s7ok4uw	3637	5	early	early	RB
cord-001835-0s7ok4uw	3637	6	because	because	IN
cord-001835-0s7ok4uw	3637	7	at	at	RB
cord-001835-0s7ok4uw	3637	8	least	least	RBS
cord-001835-0s7ok4uw	3637	9	one	one	CD
cord-001835-0s7ok4uw	3637	10	gene	gene	NN
cord-001835-0s7ok4uw	3637	11	that	that	WDT
cord-001835-0s7ok4uw	3637	12	encodes	encode	VBZ
cord-001835-0s7ok4uw	3637	13	NDK	NDK	NNP
cord-001835-0s7ok4uw	3637	14	is	be	VBZ
cord-001835-0s7ok4uw	3637	15	present	present	JJ
cord-001835-0s7ok4uw	3637	16	in	in	IN
cord-001835-0s7ok4uw	3637	17	most	most	JJS
cord-001835-0s7ok4uw	3637	18	extant	extant	JJ
cord-001835-0s7ok4uw	3637	19	organisms	organism	NNS
cord-001835-0s7ok4uw	3637	20	.	.	.
cord-001835-0s7ok4uw	3638	1	The	the	DT
cord-001835-0s7ok4uw	3638	2	first	first	JJ
cord-001835-0s7ok4uw	3638	3	step	step	NN
cord-001835-0s7ok4uw	3638	4	in	in	IN
cord-001835-0s7ok4uw	3638	5	the	the	DT
cord-001835-0s7ok4uw	3638	6	reconstruction	reconstruction	NN
cord-001835-0s7ok4uw	3638	7	of	of	IN
cord-001835-0s7ok4uw	3638	8	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	3638	9	NDK	NDK	NNP
cord-001835-0s7ok4uw	3638	10	sequences	sequence	NNS
cord-001835-0s7ok4uw	3638	11	is	be	VBZ
cord-001835-0s7ok4uw	3638	12	to	to	TO
cord-001835-0s7ok4uw	3638	13	prepare	prepare	VB
cord-001835-0s7ok4uw	3638	14	multiple	multiple	JJ
cord-001835-0s7ok4uw	3638	15	amino	amino	NN
cord-001835-0s7ok4uw	3638	16	acid	acid	NN
cord-001835-0s7ok4uw	3638	17	sequence	sequence	NN
cord-001835-0s7ok4uw	3638	18	alignments	alignment	NNS
cord-001835-0s7ok4uw	3638	19	using	use	VBG
cord-001835-0s7ok4uw	3638	20	homologous	homologous	JJ
cord-001835-0s7ok4uw	3638	21	sequences	sequence	NNS
cord-001835-0s7ok4uw	3638	22	of	of	IN
cord-001835-0s7ok4uw	3638	23	NDK	NDK	NNP
cord-001835-0s7ok4uw	3638	24	from	from	IN
cord-001835-0s7ok4uw	3638	25	extant	extant	JJ
cord-001835-0s7ok4uw	3638	26	species	specie	NNS
cord-001835-0s7ok4uw	3638	27	.	.	.
cord-001835-0s7ok4uw	3639	1	Then	then	RB
cord-001835-0s7ok4uw	3639	2	,	,	,
cord-001835-0s7ok4uw	3639	3	phylogenetic	phylogenetic	JJ
cord-001835-0s7ok4uw	3639	4	trees	tree	NNS
cord-001835-0s7ok4uw	3639	5	were	be	VBD
cord-001835-0s7ok4uw	3639	6	built	build	VBN
cord-001835-0s7ok4uw	3639	7	.	.	.
cord-001835-0s7ok4uw	3640	1	Ancestral	ancestral	JJ
cord-001835-0s7ok4uw	3640	2	sequences	sequence	NNS
cord-001835-0s7ok4uw	3640	3	of	of	IN
cord-001835-0s7ok4uw	3640	4	NDK	NDK	NNP
cord-001835-0s7ok4uw	3640	5	that	that	WDT
cord-001835-0s7ok4uw	3640	6	represent	represent	VBP
cord-001835-0s7ok4uw	3640	7	the	the	DT
cord-001835-0s7ok4uw	3640	8	last	last	JJ
cord-001835-0s7ok4uw	3640	9	common	common	JJ
cord-001835-0s7ok4uw	3640	10	ancestors	ancestor	NNS
cord-001835-0s7ok4uw	3640	11	of	of	IN
cord-001835-0s7ok4uw	3640	12	Archaea	Archaea	NNP
cord-001835-0s7ok4uw	3640	13	and	and	CC
cord-001835-0s7ok4uw	3640	14	of	of	IN
cord-001835-0s7ok4uw	3640	15	Bacteria	Bacteria	NNS
cord-001835-0s7ok4uw	3640	16	were	be	VBD
cord-001835-0s7ok4uw	3640	17	reconstructed	reconstruct	VBN
cord-001835-0s7ok4uw	3640	18	using	use	VBG
cord-001835-0s7ok4uw	3640	19	the	the	DT
cord-001835-0s7ok4uw	3640	20	information	information	NN
cord-001835-0s7ok4uw	3640	21	contained	contain	VBN
cord-001835-0s7ok4uw	3640	22	in	in	IN
cord-001835-0s7ok4uw	3640	23	the	the	DT
cord-001835-0s7ok4uw	3640	24	predictive	predictive	JJ
cord-001835-0s7ok4uw	3640	25	phylogenetic	phylogenetic	JJ
cord-001835-0s7ok4uw	3640	26	trees	tree	NNS
cord-001835-0s7ok4uw	3640	27	.	.	.
cord-001835-0s7ok4uw	3641	1	The	the	DT
cord-001835-0s7ok4uw	3641	2	reconstructed	reconstruct	VBN
cord-001835-0s7ok4uw	3641	3	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	3641	4	kinases	kinase	NNS
cord-001835-0s7ok4uw	3641	5	are	be	VBP
cord-001835-0s7ok4uw	3641	6	extremely	extremely	RB
cord-001835-0s7ok4uw	3641	7	thermally	thermally	RB
cord-001835-0s7ok4uw	3641	8	stable	stable	JJ
cord-001835-0s7ok4uw	3642	1	[	[	-LRB-
cord-001835-0s7ok4uw	3642	2	Akanuma	Akanuma	NNP
cord-001835-0s7ok4uw	3642	3	et	et	NNP
cord-001835-0s7ok4uw	3642	4	al	al	NNP
cord-001835-0s7ok4uw	3642	5	.	.	NNP
cord-001835-0s7ok4uw	3642	6	,	,	,
cord-001835-0s7ok4uw	3642	7	2013	2013	CD
cord-001835-0s7ok4uw	3642	8	]	]	-RRB-
cord-001835-0s7ok4uw	3642	9	.	.	.
cord-001835-0s7ok4uw	3643	1	Then	then	RB
cord-001835-0s7ok4uw	3643	2	,	,	,
cord-001835-0s7ok4uw	3643	3	using	use	VBG
cord-001835-0s7ok4uw	3643	4	the	the	DT
cord-001835-0s7ok4uw	3643	5	most	most	RBS
cord-001835-0s7ok4uw	3643	6	thermally	thermally	RB
cord-001835-0s7ok4uw	3643	7	stable	stable	JJ
cord-001835-0s7ok4uw	3643	8	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	3643	9	NDK	ndk	NN
cord-001835-0s7ok4uw	3643	10	,	,	,
cord-001835-0s7ok4uw	3643	11	Arc1	Arc1	NNP
cord-001835-0s7ok4uw	3643	12	,	,	,
cord-001835-0s7ok4uw	3643	13	as	as	IN
cord-001835-0s7ok4uw	3643	14	the	the	DT
cord-001835-0s7ok4uw	3643	15	starting	starting	NN
cord-001835-0s7ok4uw	3643	16	molecule	molecule	NN
cord-001835-0s7ok4uw	3643	17	,	,	,
cord-001835-0s7ok4uw	3643	18	I	-PRON-	PRP
cord-001835-0s7ok4uw	3643	19	restricted	restrict	VBD
cord-001835-0s7ok4uw	3643	20	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3643	21	amino	amino	NN
cord-001835-0s7ok4uw	3643	22	acid	acid	NN
cord-001835-0s7ok4uw	3643	23	usage	usage	NN
cord-001835-0s7ok4uw	3643	24	.	.	.
cord-001835-0s7ok4uw	3644	1	Arc1	Arc1	NNP
cord-001835-0s7ok4uw	3644	2	does	do	VBZ
cord-001835-0s7ok4uw	3644	3	not	not	RB
cord-001835-0s7ok4uw	3644	4	contain	contain	VB
cord-001835-0s7ok4uw	3644	5	any	any	DT
cord-001835-0s7ok4uw	3644	6	cysteine	cysteine	NN
cord-001835-0s7ok4uw	3644	7	residue	residue	NN
cord-001835-0s7ok4uw	3644	8	and	and	CC
cord-001835-0s7ok4uw	3644	9	therefore	therefore	RB
cord-001835-0s7ok4uw	3644	10	consists	consist	VBZ
cord-001835-0s7ok4uw	3644	11	of	of	IN
cord-001835-0s7ok4uw	3644	12	19	19	CD
cord-001835-0s7ok4uw	3644	13	amino	amino	NN
cord-001835-0s7ok4uw	3644	14	acid	acid	NN
cord-001835-0s7ok4uw	3644	15	species	specie	NNS
cord-001835-0s7ok4uw	3644	16	.	.	.
cord-001835-0s7ok4uw	3645	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	3645	2	completely	completely	RB
cord-001835-0s7ok4uw	3645	3	replaced	replace	VBD
cord-001835-0s7ok4uw	3645	4	one	one	CD
cord-001835-0s7ok4uw	3645	5	of	of	IN
cord-001835-0s7ok4uw	3645	6	the	the	DT
cord-001835-0s7ok4uw	3645	7	19	19	CD
cord-001835-0s7ok4uw	3645	8	amino	amino	NN
cord-001835-0s7ok4uw	3645	9	acid	acid	NN
cord-001835-0s7ok4uw	3645	10	species	specie	NNS
cord-001835-0s7ok4uw	3645	11	by	by	IN
cord-001835-0s7ok4uw	3645	12	other	other	JJ
cord-001835-0s7ok4uw	3645	13	amino	amino	NN
cord-001835-0s7ok4uw	3645	14	acid	acid	NN
cord-001835-0s7ok4uw	3645	15	species	specie	NNS
cord-001835-0s7ok4uw	3645	16	and	and	CC
cord-001835-0s7ok4uw	3645	17	thus	thus	RB
cord-001835-0s7ok4uw	3645	18	created	create	VBN
cord-001835-0s7ok4uw	3645	19	19	19	CD
cord-001835-0s7ok4uw	3645	20	proteins	protein	NNS
cord-001835-0s7ok4uw	3645	21	each	each	DT
cord-001835-0s7ok4uw	3645	22	of	of	IN
cord-001835-0s7ok4uw	3645	23	which	which	WDT
cord-001835-0s7ok4uw	3645	24	consisted	consist	VBD
cord-001835-0s7ok4uw	3645	25	of	of	IN
cord-001835-0s7ok4uw	3645	26	18	18	CD
cord-001835-0s7ok4uw	3645	27	amino	amino	NN
cord-001835-0s7ok4uw	3645	28	acid	acid	NN
cord-001835-0s7ok4uw	3645	29	species	specie	NNS
cord-001835-0s7ok4uw	3645	30	.	.	.
cord-001835-0s7ok4uw	3646	1	Then	then	RB
cord-001835-0s7ok4uw	3646	2	,	,	,
cord-001835-0s7ok4uw	3646	3	I	-PRON-	PRP
cord-001835-0s7ok4uw	3646	4	evaluated	evaluate	VBD
cord-001835-0s7ok4uw	3646	5	the	the	DT
cord-001835-0s7ok4uw	3646	6	stabilities	stability	NNS
cord-001835-0s7ok4uw	3646	7	and	and	CC
cord-001835-0s7ok4uw	3646	8	activities	activity	NNS
cord-001835-0s7ok4uw	3646	9	of	of	IN
cord-001835-0s7ok4uw	3646	10	the	the	DT
cord-001835-0s7ok4uw	3646	11	resulting	result	VBG
cord-001835-0s7ok4uw	3646	12	19	19	CD
cord-001835-0s7ok4uw	3646	13	Arc1	arc1	JJ
cord-001835-0s7ok4uw	3646	14	variants	variant	NNS
cord-001835-0s7ok4uw	3646	15	to	to	TO
cord-001835-0s7ok4uw	3646	16	assess	assess	VB
cord-001835-0s7ok4uw	3646	17	the	the	DT
cord-001835-0s7ok4uw	3646	18	individual	individual	JJ
cord-001835-0s7ok4uw	3646	19	contributions	contribution	NNS
cord-001835-0s7ok4uw	3646	20	of	of	IN
cord-001835-0s7ok4uw	3646	21	the	the	DT
cord-001835-0s7ok4uw	3646	22	19	19	CD
cord-001835-0s7ok4uw	3646	23	amino	amino	NN
cord-001835-0s7ok4uw	3646	24	acid	acid	NN
cord-001835-0s7ok4uw	3646	25	species	specie	NNS
cord-001835-0s7ok4uw	3646	26	.	.	.
cord-001835-0s7ok4uw	3647	1	As	as	IN
cord-001835-0s7ok4uw	3647	2	the	the	DT
cord-001835-0s7ok4uw	3647	3	result	result	NN
cord-001835-0s7ok4uw	3647	4	,	,	,
cord-001835-0s7ok4uw	3647	5	I	-PRON-	PRP
cord-001835-0s7ok4uw	3647	6	found	find	VBD
cord-001835-0s7ok4uw	3647	7	that	that	IN
cord-001835-0s7ok4uw	3647	8	the	the	DT
cord-001835-0s7ok4uw	3647	9	19	19	CD
cord-001835-0s7ok4uw	3647	10	amino	amino	NN
cord-001835-0s7ok4uw	3647	11	acid	acid	NN
cord-001835-0s7ok4uw	3647	12	species	specie	NNS
cord-001835-0s7ok4uw	3647	13	do	do	VBP
cord-001835-0s7ok4uw	3647	14	not	not	RB
cord-001835-0s7ok4uw	3647	15	equally	equally	RB
cord-001835-0s7ok4uw	3647	16	contribute	contribute	VB
cord-001835-0s7ok4uw	3647	17	to	to	IN
cord-001835-0s7ok4uw	3647	18	the	the	DT
cord-001835-0s7ok4uw	3647	19	stability	stability	NN
cord-001835-0s7ok4uw	3647	20	and	and	CC
cord-001835-0s7ok4uw	3647	21	activity	activity	NN
cord-001835-0s7ok4uw	3647	22	of	of	IN
cord-001835-0s7ok4uw	3647	23	Arc1	Arc1	NNP
cord-001835-0s7ok4uw	3647	24	and	and	CC
cord-001835-0s7ok4uw	3647	25	that	that	IN
cord-001835-0s7ok4uw	3647	26	some	some	DT
cord-001835-0s7ok4uw	3647	27	amino	amino	NN
cord-001835-0s7ok4uw	3647	28	acid	acid	NN
cord-001835-0s7ok4uw	3647	29	species	specie	NNS
cord-001835-0s7ok4uw	3647	30	can	can	MD
cord-001835-0s7ok4uw	3647	31	be	be	VB
cord-001835-0s7ok4uw	3647	32	easily	easily	RB
cord-001835-0s7ok4uw	3647	33	lacked	lack	VBN
cord-001835-0s7ok4uw	3647	34	but	but	CC
cord-001835-0s7ok4uw	3647	35	others	other	NNS
cord-001835-0s7ok4uw	3647	36	are	be	VBP
cord-001835-0s7ok4uw	3647	37	important	important	JJ
cord-001835-0s7ok4uw	3647	38	or	or	CC
cord-001835-0s7ok4uw	3647	39	essential	essential	JJ
cord-001835-0s7ok4uw	3647	40	for	for	IN
cord-001835-0s7ok4uw	3647	41	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3647	42	stability	stability	NN
cord-001835-0s7ok4uw	3647	43	and	and	CC
cord-001835-0s7ok4uw	3647	44	function	function	NN
cord-001835-0s7ok4uw	3647	45	.	.	.
cord-001835-0s7ok4uw	3648	1	The	the	DT
cord-001835-0s7ok4uw	3648	2	result	result	NN
cord-001835-0s7ok4uw	3648	3	clearly	clearly	RB
cord-001835-0s7ok4uw	3648	4	shows	show	VBZ
cord-001835-0s7ok4uw	3648	5	that	that	IN
cord-001835-0s7ok4uw	3648	6	the	the	DT
cord-001835-0s7ok4uw	3648	7	full	full	JJ
cord-001835-0s7ok4uw	3648	8	amino	amino	NN
cord-001835-0s7ok4uw	3648	9	acid	acid	NN
cord-001835-0s7ok4uw	3648	10	species	specie	NNS
cord-001835-0s7ok4uw	3648	11	are	be	VBP
cord-001835-0s7ok4uw	3648	12	not	not	RB
cord-001835-0s7ok4uw	3648	13	necessarily	necessarily	RB
cord-001835-0s7ok4uw	3648	14	essential	essential	JJ
cord-001835-0s7ok4uw	3648	15	and	and	CC
cord-001835-0s7ok4uw	3648	16	supports	support	VBZ
cord-001835-0s7ok4uw	3648	17	the	the	DT
cord-001835-0s7ok4uw	3648	18	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	3648	19	that	that	IN
cord-001835-0s7ok4uw	3648	20	proteins	protein	VBZ
cord-001835-0s7ok4uw	3648	21	in	in	IN
cord-001835-0s7ok4uw	3648	22	the	the	DT
cord-001835-0s7ok4uw	3648	23	early	early	JJ
cord-001835-0s7ok4uw	3648	24	stage	stage	NN
cord-001835-0s7ok4uw	3648	25	of	of	IN
cord-001835-0s7ok4uw	3648	26	evolution	evolution	NN
cord-001835-0s7ok4uw	3648	27	were	be	VBD
cord-001835-0s7ok4uw	3648	28	made	make	VBN
cord-001835-0s7ok4uw	3648	29	from	from	IN
cord-001835-0s7ok4uw	3648	30	a	a	DT
cord-001835-0s7ok4uw	3648	31	reduced	reduce	VBN
cord-001835-0s7ok4uw	3648	32	amino	amino	NN
cord-001835-0s7ok4uw	3648	33	acid	acid	NN
cord-001835-0s7ok4uw	3648	34	set	set	NN
cord-001835-0s7ok4uw	3648	35	.	.	.
cord-001835-0s7ok4uw	3649	1	The	the	DT
cord-001835-0s7ok4uw	3649	2	protein	protein	NN
cord-001835-0s7ok4uw	3649	3	surface	surface	NN
cord-001835-0s7ok4uw	3649	4	recognition	recognition	NN
cord-001835-0s7ok4uw	3649	5	for	for	IN
cord-001835-0s7ok4uw	3649	6	protein	protein	NN
cord-001835-0s7ok4uw	3649	7	-	-	HYPH
cord-001835-0s7ok4uw	3649	8	protein	protein	NN
cord-001835-0s7ok4uw	3649	9	interactions	interaction	NNS
cord-001835-0s7ok4uw	3649	10	(	(	-LRB-
cord-001835-0s7ok4uw	3649	11	PPI	PPI	NNP
cord-001835-0s7ok4uw	3649	12	)	)	-RRB-
cord-001835-0s7ok4uw	3649	13	is	be	VBZ
cord-001835-0s7ok4uw	3649	14	involved	involve	VBN
cord-001835-0s7ok4uw	3649	15	in	in	IN
cord-001835-0s7ok4uw	3649	16	signal	signal	NN
cord-001835-0s7ok4uw	3649	17	transduction	transduction	NN
cord-001835-0s7ok4uw	3649	18	,	,	,
cord-001835-0s7ok4uw	3649	19	immune	immune	JJ
cord-001835-0s7ok4uw	3649	20	reaction	reaction	NN
cord-001835-0s7ok4uw	3649	21	,	,	,
cord-001835-0s7ok4uw	3649	22	and	and	CC
cord-001835-0s7ok4uw	3649	23	creation	creation	NN
cord-001835-0s7ok4uw	3649	24	of	of	IN
cord-001835-0s7ok4uw	3649	25	the	the	DT
cord-001835-0s7ok4uw	3649	26	nanostructures	nanostructure	NNS
cord-001835-0s7ok4uw	3649	27	in	in	IN
cord-001835-0s7ok4uw	3649	28	living	living	NN
cord-001835-0s7ok4uw	3649	29	cells	cell	NNS
cord-001835-0s7ok4uw	3649	30	.	.	.
cord-001835-0s7ok4uw	3650	1	The	the	DT
cord-001835-0s7ok4uw	3650	2	methods	method	NNS
cord-001835-0s7ok4uw	3650	3	for	for	IN
cord-001835-0s7ok4uw	3650	4	rational	rational	JJ
cord-001835-0s7ok4uw	3650	5	designing	designing	NN
cord-001835-0s7ok4uw	3650	6	of	of	IN
cord-001835-0s7ok4uw	3650	7	PPI	PPI	NNP
cord-001835-0s7ok4uw	3650	8	that	that	WDT
cord-001835-0s7ok4uw	3650	9	could	could	MD
cord-001835-0s7ok4uw	3650	10	provide	provide	VB
cord-001835-0s7ok4uw	3650	11	non	non	JJ
cord-001835-0s7ok4uw	3650	12	-	-	JJ
cord-001835-0s7ok4uw	3650	13	antibody	antibody	JJ
cord-001835-0s7ok4uw	3650	14	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3650	15	and	and	CC
cord-001835-0s7ok4uw	3650	16	nanostructured	nanostructured	JJ
cord-001835-0s7ok4uw	3650	17	materials	material	NNS
cord-001835-0s7ok4uw	3650	18	are	be	VBP
cord-001835-0s7ok4uw	3650	19	required	require	VBN
cord-001835-0s7ok4uw	3650	20	for	for	IN
cord-001835-0s7ok4uw	3650	21	the	the	DT
cord-001835-0s7ok4uw	3650	22	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	3650	23	and	and	CC
cord-001835-0s7ok4uw	3650	24	nanotechnological	nanotechnological	JJ
cord-001835-0s7ok4uw	3650	25	applications	application	NNS
cord-001835-0s7ok4uw	3650	26	.	.	.
cord-001835-0s7ok4uw	3651	1	Although	although	IN
cord-001835-0s7ok4uw	3651	2	there	there	EX
cord-001835-0s7ok4uw	3651	3	have	have	VBP
cord-001835-0s7ok4uw	3651	4	been	be	VBN
cord-001835-0s7ok4uw	3651	5	some	some	DT
cord-001835-0s7ok4uw	3651	6	successful	successful	JJ
cord-001835-0s7ok4uw	3651	7	rational	rational	JJ
cord-001835-0s7ok4uw	3651	8	designs	design	NNS
cord-001835-0s7ok4uw	3651	9	with	with	IN
cord-001835-0s7ok4uw	3651	10	computational	computational	JJ
cord-001835-0s7ok4uw	3651	11	methods	method	NNS
cord-001835-0s7ok4uw	3651	12	,	,	,
cord-001835-0s7ok4uw	3651	13	it	-PRON-	PRP
cord-001835-0s7ok4uw	3651	14	is	be	VBZ
cord-001835-0s7ok4uw	3651	15	still	still	RB
cord-001835-0s7ok4uw	3651	16	difficult	difficult	JJ
cord-001835-0s7ok4uw	3651	17	to	to	TO
cord-001835-0s7ok4uw	3651	18	design	design	VB
cord-001835-0s7ok4uw	3651	19	freely	freely	RB
cord-001835-0s7ok4uw	3651	20	the	the	DT
cord-001835-0s7ok4uw	3651	21	PPI	PPI	NNP
cord-001835-0s7ok4uw	3651	22	onto	onto	IN
cord-001835-0s7ok4uw	3651	23	arbitrary	arbitrary	JJ
cord-001835-0s7ok4uw	3651	24	proteins	protein	NNS
cord-001835-0s7ok4uw	3651	25	.	.	.
cord-001835-0s7ok4uw	3652	1	The	the	DT
cord-001835-0s7ok4uw	3652	2	reason	reason	NN
cord-001835-0s7ok4uw	3652	3	for	for	IN
cord-001835-0s7ok4uw	3652	4	this	this	DT
cord-001835-0s7ok4uw	3652	5	limitation	limitation	NN
cord-001835-0s7ok4uw	3652	6	is	be	VBZ
cord-001835-0s7ok4uw	3652	7	decreased	decrease	VBN
cord-001835-0s7ok4uw	3652	8	solubility	solubility	NN
cord-001835-0s7ok4uw	3652	9	in	in	IN
cord-001835-0s7ok4uw	3652	10	the	the	DT
cord-001835-0s7ok4uw	3652	11	designed	design	VBN
cord-001835-0s7ok4uw	3652	12	protein	protein	NN
cord-001835-0s7ok4uw	3652	13	due	due	IN
cord-001835-0s7ok4uw	3652	14	to	to	IN
cord-001835-0s7ok4uw	3652	15	the	the	DT
cord-001835-0s7ok4uw	3652	16	additional	additional	JJ
cord-001835-0s7ok4uw	3652	17	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3652	18	residues	residue	NNS
cord-001835-0s7ok4uw	3652	19	in	in	IN
cord-001835-0s7ok4uw	3652	20	order	order	NN
cord-001835-0s7ok4uw	3652	21	to	to	TO
cord-001835-0s7ok4uw	3652	22	drive	drive	VB
cord-001835-0s7ok4uw	3652	23	PPI	PPI	NNP
cord-001835-0s7ok4uw	3652	24	.	.	.
cord-001835-0s7ok4uw	3653	1	Another	another	DT
cord-001835-0s7ok4uw	3653	2	reason	reason	NN
cord-001835-0s7ok4uw	3653	3	is	be	VBZ
cord-001835-0s7ok4uw	3653	4	a	a	DT
cord-001835-0s7ok4uw	3653	5	limited	limited	JJ
cord-001835-0s7ok4uw	3653	6	set	set	NN
cord-001835-0s7ok4uw	3653	7	of	of	IN
cord-001835-0s7ok4uw	3653	8	design	design	NN
cord-001835-0s7ok4uw	3653	9	modes	mode	NNS
cord-001835-0s7ok4uw	3653	10	by	by	IN
cord-001835-0s7ok4uw	3653	11	which	which	WDT
cord-001835-0s7ok4uw	3653	12	proteins	protein	NNS
cord-001835-0s7ok4uw	3653	13	can	can	MD
cord-001835-0s7ok4uw	3653	14	interact	interact	VB
cord-001835-0s7ok4uw	3653	15	,	,	,
cord-001835-0s7ok4uw	3653	16	because	because	IN
cord-001835-0s7ok4uw	3653	17	the	the	DT
cord-001835-0s7ok4uw	3653	18	target	target	NN
cord-001835-0s7ok4uw	3653	19	proteins	protein	NNS
cord-001835-0s7ok4uw	3653	20	have	have	VBP
cord-001835-0s7ok4uw	3653	21	individual	individual	JJ
cord-001835-0s7ok4uw	3653	22	surface	surface	NN
cord-001835-0s7ok4uw	3653	23	structures	structure	NNS
cord-001835-0s7ok4uw	3653	24	.	.	.
cord-001835-0s7ok4uw	3654	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	3654	2	,	,	,
cord-001835-0s7ok4uw	3654	3	many	many	JJ
cord-001835-0s7ok4uw	3654	4	methods	method	NNS
cord-001835-0s7ok4uw	3654	5	of	of	IN
cord-001835-0s7ok4uw	3654	6	constructing	construct	VBG
cord-001835-0s7ok4uw	3654	7	an	an	DT
cord-001835-0s7ok4uw	3654	8	interface	interface	NN
cord-001835-0s7ok4uw	3654	9	for	for	IN
cord-001835-0s7ok4uw	3654	10	numerous	numerous	JJ
cord-001835-0s7ok4uw	3654	11	target	target	NN
cord-001835-0s7ok4uw	3654	12	scaffold	scaffold	NN
cord-001835-0s7ok4uw	3654	13	proteins	protein	NNS
cord-001835-0s7ok4uw	3654	14	without	without	IN
cord-001835-0s7ok4uw	3654	15	loss	loss	NN
cord-001835-0s7ok4uw	3654	16	of	of	IN
cord-001835-0s7ok4uw	3654	17	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3654	18	solubility	solubility	NN
cord-001835-0s7ok4uw	3654	19	are	be	VBP
cord-001835-0s7ok4uw	3654	20	necessary	necessary	JJ
cord-001835-0s7ok4uw	3654	21	.	.	.
cord-001835-0s7ok4uw	3655	1	Surface	surface	NN
cord-001835-0s7ok4uw	3655	2	exposed	expose	VBD
cord-001835-0s7ok4uw	3655	3	a	a	DT
cord-001835-0s7ok4uw	3655	4	-	-	:
cord-001835-0s7ok4uw	3655	5	helices	helix	NNS
cord-001835-0s7ok4uw	3655	6	are	be	VBP
cord-001835-0s7ok4uw	3655	7	often	often	RB
cord-001835-0s7ok4uw	3655	8	observed	observe	VBN
cord-001835-0s7ok4uw	3655	9	in	in	IN
cord-001835-0s7ok4uw	3655	10	natural	natural	JJ
cord-001835-0s7ok4uw	3655	11	globular	globular	JJ
cord-001835-0s7ok4uw	3655	12	proteins	protein	NNS
cord-001835-0s7ok4uw	3655	13	.	.	.
cord-001835-0s7ok4uw	3656	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	3656	2	,	,	,
cord-001835-0s7ok4uw	3656	3	there	there	EX
cord-001835-0s7ok4uw	3656	4	are	be	VBP
cord-001835-0s7ok4uw	3656	5	many	many	JJ
cord-001835-0s7ok4uw	3656	6	examples	example	NNS
cord-001835-0s7ok4uw	3656	7	for	for	IN
cord-001835-0s7ok4uw	3656	8	naturally	naturally	RB
cord-001835-0s7ok4uw	3656	9	occurring	occur	VBG
cord-001835-0s7ok4uw	3656	10	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	3656	11	proteins	protein	NNS
cord-001835-0s7ok4uw	3656	12	where	where	WRB
cord-001835-0s7ok4uw	3656	13	an	an	DT
cord-001835-0s7ok4uw	3656	14	a	a	DT
cord-001835-0s7ok4uw	3656	15	-	-	HYPH
cord-001835-0s7ok4uw	3656	16	helix	helix	NN
cord-001835-0s7ok4uw	3656	17	from	from	IN
cord-001835-0s7ok4uw	3656	18	each	each	DT
cord-001835-0s7ok4uw	3656	19	subunit	subunit	NN
cord-001835-0s7ok4uw	3656	20	interacts	interact	VBZ
cord-001835-0s7ok4uw	3656	21	to	to	TO
cord-001835-0s7ok4uw	3656	22	form	form	VB
cord-001835-0s7ok4uw	3656	23	an	an	DT
cord-001835-0s7ok4uw	3656	24	intermolecule	intermolecule	NN
cord-001835-0s7ok4uw	3656	25	coiled	coiled	JJ
cord-001835-0s7ok4uw	3656	26	coil	coil	NN
cord-001835-0s7ok4uw	3656	27	.	.	.
cord-001835-0s7ok4uw	3657	1	Further	further	RB
cord-001835-0s7ok4uw	3657	2	,	,	,
cord-001835-0s7ok4uw	3657	3	the	the	DT
cord-001835-0s7ok4uw	3657	4	works	work	NNS
cord-001835-0s7ok4uw	3657	5	related	relate	VBN
cord-001835-0s7ok4uw	3657	6	to	to	IN
cord-001835-0s7ok4uw	3657	7	designing	design	VBG
cord-001835-0s7ok4uw	3657	8	of	of	IN
cord-001835-0s7ok4uw	3657	9	artificial	artificial	JJ
cord-001835-0s7ok4uw	3657	10	helical	helical	JJ
cord-001835-0s7ok4uw	3657	11	bundle	bundle	NN
cord-001835-0s7ok4uw	3657	12	reported	report	VBN
cord-001835-0s7ok4uw	3657	13	by	by	IN
cord-001835-0s7ok4uw	3657	14	the	the	DT
cord-001835-0s7ok4uw	3657	15	several	several	JJ
cord-001835-0s7ok4uw	3657	16	other	other	JJ
cord-001835-0s7ok4uw	3657	17	groups	group	NNS
cord-001835-0s7ok4uw	3657	18	have	have	VBP
cord-001835-0s7ok4uw	3657	19	provided	provide	VBN
cord-001835-0s7ok4uw	3657	20	information	information	NN
cord-001835-0s7ok4uw	3657	21	about	about	IN
cord-001835-0s7ok4uw	3657	22	how	how	WRB
cord-001835-0s7ok4uw	3657	23	to	to	TO
cord-001835-0s7ok4uw	3657	24	generate	generate	VB
cord-001835-0s7ok4uw	3657	25	and	and	CC
cord-001835-0s7ok4uw	3657	26	tune	tune	VB
cord-001835-0s7ok4uw	3657	27	the	the	DT
cord-001835-0s7ok4uw	3657	28	interaction	interaction	NN
cord-001835-0s7ok4uw	3657	29	between	between	IN
cord-001835-0s7ok4uw	3657	30	a	a	DT
cord-001835-0s7ok4uw	3657	31	-	-	:
cord-001835-0s7ok4uw	3657	32	helices	helix	NNS
cord-001835-0s7ok4uw	3657	33	.	.	.
cord-001835-0s7ok4uw	3658	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	3658	2	,	,	,
cord-001835-0s7ok4uw	3658	3	a	a	DT
cord-001835-0s7ok4uw	3658	4	surface	surface	NN
cord-001835-0s7ok4uw	3658	5	exposed	expose	VBD
cord-001835-0s7ok4uw	3658	6	a	a	DT
cord-001835-0s7ok4uw	3658	7	-	-	HYPH
cord-001835-0s7ok4uw	3658	8	helix	helix	NN
cord-001835-0s7ok4uw	3658	9	would	would	MD
cord-001835-0s7ok4uw	3658	10	be	be	VB
cord-001835-0s7ok4uw	3658	11	a	a	DT
cord-001835-0s7ok4uw	3658	12	good	good	JJ
cord-001835-0s7ok4uw	3658	13	target	target	NN
cord-001835-0s7ok4uw	3658	14	for	for	IN
cord-001835-0s7ok4uw	3658	15	designing	design	VBG
cord-001835-0s7ok4uw	3658	16	a	a	DT
cord-001835-0s7ok4uw	3658	17	de	de	FW
cord-001835-0s7ok4uw	3658	18	novo	novo	NN
cord-001835-0s7ok4uw	3658	19	interface	interface	NN
cord-001835-0s7ok4uw	3658	20	onto	onto	IN
cord-001835-0s7ok4uw	3658	21	the	the	DT
cord-001835-0s7ok4uw	3658	22	scaffold	scaffold	NN
cord-001835-0s7ok4uw	3658	23	protein	protein	NN
cord-001835-0s7ok4uw	3658	24	.	.	.
cord-001835-0s7ok4uw	3659	1	Here	here	RB
cord-001835-0s7ok4uw	3659	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3659	3	engineered	engineer	VBD
cord-001835-0s7ok4uw	3659	4	two	two	CD
cord-001835-0s7ok4uw	3659	5	different	different	JJ
cord-001835-0s7ok4uw	3659	6	proteins	protein	NNS
cord-001835-0s7ok4uw	3659	7	,	,	,
cord-001835-0s7ok4uw	3659	8	sulerythrin	sulerythrin	NNP
cord-001835-0s7ok4uw	3659	9	and	and	CC
cord-001835-0s7ok4uw	3659	10	cys	cys	NNP
cord-001835-0s7ok4uw	3659	11	-	-	HYPH
cord-001835-0s7ok4uw	3659	12	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3659	13	,	,	,
cord-001835-0s7ok4uw	3659	14	to	to	TO
cord-001835-0s7ok4uw	3659	15	form	form	VB
cord-001835-0s7ok4uw	3659	16	the	the	DT
cord-001835-0s7ok4uw	3659	17	cys	cys	NNP
cord-001835-0s7ok4uw	3659	18	-	-	HYPH
cord-001835-0s7ok4uw	3659	19	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3659	20	-	-	HYPH
cord-001835-0s7ok4uw	3659	21	sulerythrin	sulerythrin	NNP
cord-001835-0s7ok4uw	3659	22	dimer	dimer	NNP
cord-001835-0s7ok4uw	3659	23	-	-	HYPH
cord-001835-0s7ok4uw	3659	24	cys	cys	NNP
cord-001835-0s7ok4uw	3659	25	-	-	HYPH
cord-001835-0s7ok4uw	3659	26	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3659	27	heterotetramer	heterotetramer	NNP
cord-001835-0s7ok4uw	3659	28	via	via	IN
cord-001835-0s7ok4uw	3659	29	an	an	DT
cord-001835-0s7ok4uw	3659	30	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	3659	31	helix	helix	NN
cord-001835-0s7ok4uw	3659	32	-	-	HYPH
cord-001835-0s7ok4uw	3659	33	helix	helix	NN
cord-001835-0s7ok4uw	3659	34	interaction	interaction	NN
cord-001835-0s7ok4uw	3659	35	.	.	.
cord-001835-0s7ok4uw	3660	1	Wild	wild	JJ
cord-001835-0s7ok4uw	3660	2	-	-	HYPH
cord-001835-0s7ok4uw	3660	3	type	type	NN
cord-001835-0s7ok4uw	3660	4	sulerythrin	sulerythrin	NN
cord-001835-0s7ok4uw	3660	5	forms	form	VBZ
cord-001835-0s7ok4uw	3660	6	a	a	DT
cord-001835-0s7ok4uw	3660	7	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	3660	8	eight	eight	CD
cord-001835-0s7ok4uw	3660	9	-	-	HYPH
cord-001835-0s7ok4uw	3660	10	helix	helix	NN
cord-001835-0s7ok4uw	3660	11	bundle	bundle	NN
cord-001835-0s7ok4uw	3660	12	.	.	.
cord-001835-0s7ok4uw	3661	1	Cys	Cys	NNP
cord-001835-0s7ok4uw	3661	2	-	-	HYPH
cord-001835-0s7ok4uw	3661	3	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3661	4	is	be	VBZ
cord-001835-0s7ok4uw	3661	5	a	a	DT
cord-001835-0s7ok4uw	3661	6	designed	design	VBN
cord-001835-0s7ok4uw	3661	7	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	3661	8	protein	protein	NN
cord-001835-0s7ok4uw	3661	9	that	that	WDT
cord-001835-0s7ok4uw	3661	10	forms	form	VBZ
cord-001835-0s7ok4uw	3661	11	four	four	CD
cord-001835-0s7ok4uw	3661	12	-	-	HYPH
cord-001835-0s7ok4uw	3661	13	helix	helix	NN
cord-001835-0s7ok4uw	3661	14	bundle	bundle	NN
cord-001835-0s7ok4uw	3661	15	containing	contain	VBG
cord-001835-0s7ok4uw	3661	16	interhelical	interhelical	NNP
cord-001835-0s7ok4uw	3661	17	S	S	NNP
cord-001835-0s7ok4uw	3661	18	-	-	HYPH
cord-001835-0s7ok4uw	3661	19	S	S	NNP
cord-001835-0s7ok4uw	3661	20	bonds	bond	NNS
cord-001835-0s7ok4uw	3661	21	.	.	.
cord-001835-0s7ok4uw	3662	1	Both	both	DT
cord-001835-0s7ok4uw	3662	2	sulerythrin	sulerythrin	NNP
cord-001835-0s7ok4uw	3662	3	and	and	CC
cord-001835-0s7ok4uw	3662	4	cys	cys	NNP
cord-001835-0s7ok4uw	3662	5	-	-	HYPH
cord-001835-0s7ok4uw	3662	6	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3662	7	are	be	VBP
cord-001835-0s7ok4uw	3662	8	extremely	extremely	RB
cord-001835-0s7ok4uw	3662	9	thermostable	thermostable	JJ
cord-001835-0s7ok4uw	3662	10	.	.	.
cord-001835-0s7ok4uw	3663	1	To	to	TO
cord-001835-0s7ok4uw	3663	2	design	design	VB
cord-001835-0s7ok4uw	3663	3	protein	protein	NN
cord-001835-0s7ok4uw	3663	4	-	-	HYPH
cord-001835-0s7ok4uw	3663	5	protein	protein	NN
cord-001835-0s7ok4uw	3663	6	interfaces	interface	NNS
cord-001835-0s7ok4uw	3663	7	onto	onto	IN
cord-001835-0s7ok4uw	3663	8	the	the	DT
cord-001835-0s7ok4uw	3663	9	individual	individual	JJ
cord-001835-0s7ok4uw	3663	10	proteins	protein	NNS
cord-001835-0s7ok4uw	3663	11	,	,	,
cord-001835-0s7ok4uw	3663	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	3663	13	first	first	RB
cord-001835-0s7ok4uw	3663	14	introduced	introduce	VBD
cord-001835-0s7ok4uw	3663	15	six	six	CD
cord-001835-0s7ok4uw	3663	16	leucines	leucine	NNS
cord-001835-0s7ok4uw	3663	17	to	to	IN
cord-001835-0s7ok4uw	3663	18	the	the	DT
cord-001835-0s7ok4uw	3663	19	two	two	CD
cord-001835-0s7ok4uw	3663	20	a	a	DT
cord-001835-0s7ok4uw	3663	21	-	-	:
cord-001835-0s7ok4uw	3663	22	helices	helix	NNS
cord-001835-0s7ok4uw	3663	23	of	of	IN
cord-001835-0s7ok4uw	3663	24	sulerythrin	sulerythrin	NNP
cord-001835-0s7ok4uw	3663	25	and	and	CC
cord-001835-0s7ok4uw	3663	26	three	three	CD
cord-001835-0s7ok4uw	3663	27	leucines	leucine	NNS
cord-001835-0s7ok4uw	3663	28	to	to	IN
cord-001835-0s7ok4uw	3663	29	a	a	DT
cord-001835-0s7ok4uw	3663	30	a	a	DT
cord-001835-0s7ok4uw	3663	31	-	-	HYPH
cord-001835-0s7ok4uw	3663	32	helix	helix	NN
cord-001835-0s7ok4uw	3663	33	of	of	IN
cord-001835-0s7ok4uw	3663	34	cys	cys	NNP
cord-001835-0s7ok4uw	3663	35	-	-	HYPH
cord-001835-0s7ok4uw	3663	36	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3663	37	.	.	.
cord-001835-0s7ok4uw	3664	1	As	as	IN
cord-001835-0s7ok4uw	3664	2	expected	expect	VBN
cord-001835-0s7ok4uw	3664	3	,	,	,
cord-001835-0s7ok4uw	3664	4	the	the	DT
cord-001835-0s7ok4uw	3664	5	introduction	introduction	NN
cord-001835-0s7ok4uw	3664	6	of	of	IN
cord-001835-0s7ok4uw	3664	7	the	the	DT
cord-001835-0s7ok4uw	3664	8	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3664	9	amino	amino	NN
cord-001835-0s7ok4uw	3664	10	acids	acid	NNS
cord-001835-0s7ok4uw	3664	11	reduced	reduce	VBD
cord-001835-0s7ok4uw	3664	12	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3664	13	solubilities	solubility	NNS
cord-001835-0s7ok4uw	3664	14	.	.	.
cord-001835-0s7ok4uw	3665	1	To	to	TO
cord-001835-0s7ok4uw	3665	2	recover	recover	VB
cord-001835-0s7ok4uw	3665	3	the	the	DT
cord-001835-0s7ok4uw	3665	4	solubility	solubility	NN
cord-001835-0s7ok4uw	3665	5	,	,	,
cord-001835-0s7ok4uw	3665	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	3665	7	then	then	RB
cord-001835-0s7ok4uw	3665	8	introduced	introduce	VBD
cord-001835-0s7ok4uw	3665	9	six	six	CD
cord-001835-0s7ok4uw	3665	10	aspartates	aspartate	NNS
cord-001835-0s7ok4uw	3665	11	or	or	CC
cord-001835-0s7ok4uw	3665	12	glutamates	glutamate	NNS
cord-001835-0s7ok4uw	3665	13	around	around	IN
cord-001835-0s7ok4uw	3665	14	the	the	DT
cord-001835-0s7ok4uw	3665	15	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3665	16	surface	surface	NN
cord-001835-0s7ok4uw	3665	17	of	of	IN
cord-001835-0s7ok4uw	3665	18	the	the	DT
cord-001835-0s7ok4uw	3665	19	sulerythrin	sulerythrin	NN
cord-001835-0s7ok4uw	3665	20	(	(	-LRB-
cord-001835-0s7ok4uw	3665	21	hereafter	hereafter	RB
cord-001835-0s7ok4uw	3665	22	referred	refer	VBD
cord-001835-0s7ok4uw	3665	23	to	to	IN
cord-001835-0s7ok4uw	3665	24	as	as	IN
cord-001835-0s7ok4uw	3665	25	6L6D	6l6d	CD
cord-001835-0s7ok4uw	3665	26	or	or	CC
cord-001835-0s7ok4uw	3665	27	6L6E	6l6e	CD
cord-001835-0s7ok4uw	3665	28	)	)	-RRB-
cord-001835-0s7ok4uw	3665	29	.	.	.
cord-001835-0s7ok4uw	3666	1	Similarly	similarly	RB
cord-001835-0s7ok4uw	3666	2	,	,	,
cord-001835-0s7ok4uw	3666	3	three	three	CD
cord-001835-0s7ok4uw	3666	4	arginines	arginine	NNS
cord-001835-0s7ok4uw	3666	5	were	be	VBD
cord-001835-0s7ok4uw	3666	6	introduced	introduce	VBN
cord-001835-0s7ok4uw	3666	7	around	around	IN
cord-001835-0s7ok4uw	3666	8	the	the	DT
cord-001835-0s7ok4uw	3666	9	artificial	artificial	JJ
cord-001835-0s7ok4uw	3666	10	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3666	11	surface	surface	NN
cord-001835-0s7ok4uw	3666	12	of	of	IN
cord-001835-0s7ok4uw	3666	13	the	the	DT
cord-001835-0s7ok4uw	3666	14	cys	cys	NNP
cord-001835-0s7ok4uw	3666	15	-	-	HYPH
cord-001835-0s7ok4uw	3666	16	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3666	17	(	(	-LRB-
cord-001835-0s7ok4uw	3666	18	hereafter	hereafter	RB
cord-001835-0s7ok4uw	3666	19	referred	refer	VBN
cord-001835-0s7ok4uw	3666	20	as	as	IN
cord-001835-0s7ok4uw	3666	21	IV-3L3R	IV-3L3R	NNP
cord-001835-0s7ok4uw	3666	22	)	)	-RRB-
cord-001835-0s7ok4uw	3666	23	.	.	.
cord-001835-0s7ok4uw	3667	1	The	the	DT
cord-001835-0s7ok4uw	3667	2	solubilities	solubility	NNS
cord-001835-0s7ok4uw	3667	3	of	of	IN
cord-001835-0s7ok4uw	3667	4	the	the	DT
cord-001835-0s7ok4uw	3667	5	mutants	mutant	NNS
cord-001835-0s7ok4uw	3667	6	with	with	IN
cord-001835-0s7ok4uw	3667	7	the	the	DT
cord-001835-0s7ok4uw	3667	8	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3667	9	interface	interface	NN
cord-001835-0s7ok4uw	3667	10	and	and	CC
cord-001835-0s7ok4uw	3667	11	additional	additional	JJ
cord-001835-0s7ok4uw	3667	12	charged	charge	VBN
cord-001835-0s7ok4uw	3667	13	residues	residue	NNS
cord-001835-0s7ok4uw	3667	14	were	be	VBD
cord-001835-0s7ok4uw	3667	15	recovered	recover	VBN
cord-001835-0s7ok4uw	3667	16	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3667	17	solubility	solubility	NN
cord-001835-0s7ok4uw	3667	18	.	.	.
cord-001835-0s7ok4uw	3668	1	In	in	IN
cord-001835-0s7ok4uw	3668	2	addition	addition	NN
cord-001835-0s7ok4uw	3668	3	,	,	,
cord-001835-0s7ok4uw	3668	4	the	the	DT
cord-001835-0s7ok4uw	3668	5	sulerythrin	sulerythrin	NNP
cord-001835-0s7ok4uw	3668	6	mutants	mutant	NNS
cord-001835-0s7ok4uw	3668	7	6L6D	6l6d	CD
cord-001835-0s7ok4uw	3668	8	and	and	CC
cord-001835-0s7ok4uw	3668	9	6L6E	6l6e	CD
cord-001835-0s7ok4uw	3668	10	exist	exist	VBP
cord-001835-0s7ok4uw	3668	11	mainly	mainly	RB
cord-001835-0s7ok4uw	3668	12	as	as	IN
cord-001835-0s7ok4uw	3668	13	dimer	dimer	NN
cord-001835-0s7ok4uw	3668	14	.	.	.
cord-001835-0s7ok4uw	3669	1	The	the	DT
cord-001835-0s7ok4uw	3669	2	cys	cys	NNP
cord-001835-0s7ok4uw	3669	3	-	-	HYPH
cord-001835-0s7ok4uw	3669	4	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3669	5	mutants	mutant	NNS
cord-001835-0s7ok4uw	3669	6	IV-3L3R	IV-3L3R	NNP
cord-001835-0s7ok4uw	3669	7	,	,	,
cord-001835-0s7ok4uw	3669	8	also	also	RB
cord-001835-0s7ok4uw	3669	9	exists	exist	VBZ
cord-001835-0s7ok4uw	3669	10	as	as	IN
cord-001835-0s7ok4uw	3669	11	monomer	monomer	NN
cord-001835-0s7ok4uw	3669	12	.	.	.
cord-001835-0s7ok4uw	3670	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3670	2	then	then	RB
cord-001835-0s7ok4uw	3670	3	examined	examine	VBD
cord-001835-0s7ok4uw	3670	4	the	the	DT
cord-001835-0s7ok4uw	3670	5	interaction	interaction	NN
cord-001835-0s7ok4uw	3670	6	between	between	IN
cord-001835-0s7ok4uw	3670	7	6L6E	6l6e	CD
cord-001835-0s7ok4uw	3670	8	or	or	CC
cord-001835-0s7ok4uw	3670	9	6L6D	6l6d	CD
cord-001835-0s7ok4uw	3670	10	and	and	CC
cord-001835-0s7ok4uw	3670	11	IV-3L3R.	IV-3L3R.	NNP
cord-001835-0s7ok4uw	3671	1	A	a	DT
cord-001835-0s7ok4uw	3671	2	pull	pull	VB
cord-001835-0s7ok4uw	3671	3	-	-	HYPH
cord-001835-0s7ok4uw	3671	4	down	down	RP
cord-001835-0s7ok4uw	3671	5	experiment	experiment	NN
cord-001835-0s7ok4uw	3671	6	,	,	,
cord-001835-0s7ok4uw	3671	7	in	in	IN
cord-001835-0s7ok4uw	3671	8	which	which	WDT
cord-001835-0s7ok4uw	3671	9	Co21	co21	JJ
cord-001835-0s7ok4uw	3671	10	beads	bead	NNS
cord-001835-0s7ok4uw	3671	11	bound	bind	VBN
cord-001835-0s7ok4uw	3671	12	to	to	IN
cord-001835-0s7ok4uw	3671	13	either	either	CC
cord-001835-0s7ok4uw	3671	14	His	-PRON-	PRP$
cord-001835-0s7ok4uw	3671	15	-	-	HYPH
cord-001835-0s7ok4uw	3671	16	tagged	tagged	NNP
cord-001835-0s7ok4uw	3671	17	cys	cys	NNP
cord-001835-0s7ok4uw	3671	18	-	-	HYPH
cord-001835-0s7ok4uw	3671	19	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3671	20	and	and	CC
cord-001835-0s7ok4uw	3671	21	IV-3L3R	IV-3L3R	NNP
cord-001835-0s7ok4uw	3671	22	were	be	VBD
cord-001835-0s7ok4uw	3671	23	used	use	VBN
cord-001835-0s7ok4uw	3671	24	to	to	TO
cord-001835-0s7ok4uw	3671	25	pull	pull	VB
cord-001835-0s7ok4uw	3671	26	down	down	RP
cord-001835-0s7ok4uw	3671	27	wild	wild	JJ
cord-001835-0s7ok4uw	3671	28	-	-	HYPH
cord-001835-0s7ok4uw	3671	29	type	type	NN
cord-001835-0s7ok4uw	3671	30	sulerythrin	sulerythrin	NN
cord-001835-0s7ok4uw	3671	31	,	,	,
cord-001835-0s7ok4uw	3671	32	6L6D	6l6d	CD
cord-001835-0s7ok4uw	3671	33	,	,	,
cord-001835-0s7ok4uw	3671	34	or	or	CC
cord-001835-0s7ok4uw	3671	35	6L6E	6l6e	CD
cord-001835-0s7ok4uw	3671	36	,	,	,
cord-001835-0s7ok4uw	3671	37	demonstrates	demonstrate	VBZ
cord-001835-0s7ok4uw	3671	38	that	that	IN
cord-001835-0s7ok4uw	3671	39	6L6D	6l6d	CD
cord-001835-0s7ok4uw	3671	40	or	or	CC
cord-001835-0s7ok4uw	3671	41	6L6E	6l6e	CD
cord-001835-0s7ok4uw	3671	42	specifically	specifically	RB
cord-001835-0s7ok4uw	3671	43	interacts	interact	VBZ
cord-001835-0s7ok4uw	3671	44	to	to	IN
cord-001835-0s7ok4uw	3671	45	IV-3L3R.	iv-3l3r.	PRP
cord-001835-0s7ok4uw	3672	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	3672	2	,	,	,
cord-001835-0s7ok4uw	3672	3	when	when	WRB
cord-001835-0s7ok4uw	3672	4	analysed	analyse	VBN
cord-001835-0s7ok4uw	3672	5	by	by	IN
cord-001835-0s7ok4uw	3672	6	size	size	NN
cord-001835-0s7ok4uw	3672	7	exclusion	exclusion	NN
cord-001835-0s7ok4uw	3672	8	chromatography	chromatography	NN
cord-001835-0s7ok4uw	3672	9	,	,	,
cord-001835-0s7ok4uw	3672	10	the	the	DT
cord-001835-0s7ok4uw	3672	11	dominant	dominant	JJ
cord-001835-0s7ok4uw	3672	12	peaks	peak	NNS
cord-001835-0s7ok4uw	3672	13	of	of	IN
cord-001835-0s7ok4uw	3672	14	the	the	DT
cord-001835-0s7ok4uw	3672	15	mixture	mixture	NN
cord-001835-0s7ok4uw	3672	16	of	of	IN
cord-001835-0s7ok4uw	3672	17	6L6D	6l6d	CD
cord-001835-0s7ok4uw	3673	1	and	and	CC
cord-001835-0s7ok4uw	3673	2	IV-3L3R	IV-3L3R	NNP
cord-001835-0s7ok4uw	3673	3	appeared	appear	VBD
cord-001835-0s7ok4uw	3673	4	at	at	IN
cord-001835-0s7ok4uw	3673	5	the	the	DT
cord-001835-0s7ok4uw	3673	6	volume	volume	NN
cord-001835-0s7ok4uw	3673	7	expected	expect	VBN
cord-001835-0s7ok4uw	3673	8	for	for	IN
cord-001835-0s7ok4uw	3673	9	the	the	DT
cord-001835-0s7ok4uw	3673	10	heterotetrameric	heterotetrameric	NNP
cord-001835-0s7ok4uw	3673	11	complex	complex	NN
cord-001835-0s7ok4uw	3673	12	.	.	.
cord-001835-0s7ok4uw	3674	1	Thus	thus	RB
cord-001835-0s7ok4uw	3674	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3674	3	successfully	successfully	RB
cord-001835-0s7ok4uw	3674	4	created	create	VBD
cord-001835-0s7ok4uw	3674	5	the	the	DT
cord-001835-0s7ok4uw	3674	6	de	de	FW
cord-001835-0s7ok4uw	3674	7	novo	novo	NNP
cord-001835-0s7ok4uw	3674	8	PPI	PPI	NNP
cord-001835-0s7ok4uw	3674	9	by	by	IN
cord-001835-0s7ok4uw	3674	10	using	use	VBG
cord-001835-0s7ok4uw	3674	11	a	a	DT
cord-001835-0s7ok4uw	3674	12	very	very	RB
cord-001835-0s7ok4uw	3674	13	simple	simple	JJ
cord-001835-0s7ok4uw	3674	14	concept	concept	NN
cord-001835-0s7ok4uw	3674	15	involving	involve	VBG
cord-001835-0s7ok4uw	3674	16	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3674	17	interaction	interaction	NN
cord-001835-0s7ok4uw	3674	18	in	in	IN
cord-001835-0s7ok4uw	3674	19	combination	combination	NN
cord-001835-0s7ok4uw	3674	20	with	with	IN
cord-001835-0s7ok4uw	3674	21	charge	charge	NN
cord-001835-0s7ok4uw	3674	22	interactions	interaction	NNS
cord-001835-0s7ok4uw	3674	23	.	.	.
cord-001835-0s7ok4uw	3675	1	In	in	IN
cord-001835-0s7ok4uw	3675	2	vitro	vitro	FW
cord-001835-0s7ok4uw	3675	3	selection	selection	NN
cord-001835-0s7ok4uw	3675	4	of	of	IN
cord-001835-0s7ok4uw	3675	5	liposome	liposome	NN
cord-001835-0s7ok4uw	3675	6	anchoring	anchor	VBG
cord-001835-0s7ok4uw	3675	7	peptide	peptide	NN
cord-001835-0s7ok4uw	3675	8	by	by	IN
cord-001835-0s7ok4uw	3675	9	cDNA	cdna	NN
cord-001835-0s7ok4uw	3675	10	display	display	NN
cord-001835-0s7ok4uw	3675	11	Naoto	Naoto	NNP
cord-001835-0s7ok4uw	3675	12	Nemoto	Nemoto	NNP
cord-001835-0s7ok4uw	3675	13	1	1	CD
cord-001835-0s7ok4uw	3675	14	,	,	,
cord-001835-0s7ok4uw	3675	15	Ryoya	Ryoya	NNP
cord-001835-0s7ok4uw	3675	16	Okawa	Okawa	NNP
cord-001835-0s7ok4uw	3675	17	1	1	CD
cord-001835-0s7ok4uw	3675	18	,	,	,
cord-001835-0s7ok4uw	3675	19	Yuki	Yuki	NNP
cord-001835-0s7ok4uw	3675	20	Yoshikawa	Yoshikawa	NNP
cord-001835-0s7ok4uw	3675	21	1	1	CD
cord-001835-0s7ok4uw	3675	22	,	,	,
cord-001835-0s7ok4uw	3675	23	Toshiki	Toshiki	NNP
cord-001835-0s7ok4uw	3675	24	Miyajima	Miyajima	NNP
cord-001835-0s7ok4uw	3675	25	1	1	CD
cord-001835-0s7ok4uw	3675	26	,	,	,
cord-001835-0s7ok4uw	3675	27	Shota	Shota	NNP
cord-001835-0s7ok4uw	3675	28	Kobayashi	Kobayashi	NNP
cord-001835-0s7ok4uw	3675	29	1	1	CD
cord-001835-0s7ok4uw	3675	30	1	1	CD
cord-001835-0s7ok4uw	3675	31	A	a	DT
cord-001835-0s7ok4uw	3675	32	liposome	liposome	NN
cord-001835-0s7ok4uw	3675	33	-	-	HYPH
cord-001835-0s7ok4uw	3675	34	anchoring	anchor	VBG
cord-001835-0s7ok4uw	3675	35	peptide	peptide	NN
cord-001835-0s7ok4uw	3675	36	(	(	-LRB-
cord-001835-0s7ok4uw	3675	37	LA	LA	NNP
cord-001835-0s7ok4uw	3675	38	peptide	peptide	NN
cord-001835-0s7ok4uw	3675	39	)	)	-RRB-
cord-001835-0s7ok4uw	3675	40	was	be	VBD
cord-001835-0s7ok4uw	3675	41	selected	select	VBN
cord-001835-0s7ok4uw	3675	42	against	against	IN
cord-001835-0s7ok4uw	3675	43	liposomes	liposome	NNS
cord-001835-0s7ok4uw	3675	44	composed	compose	VBN
cord-001835-0s7ok4uw	3675	45	of	of	IN
cord-001835-0s7ok4uw	3675	46	dioleoyl	dioleoyl	NNP
cord-001835-0s7ok4uw	3675	47	-	-	HYPH
cord-001835-0s7ok4uw	3675	48	snglycero-3-phosphocholine	snglycero-3-phosphocholine	NNP
cord-001835-0s7ok4uw	3675	49	(	(	-LRB-
cord-001835-0s7ok4uw	3675	50	DOPC	DOPC	NNP
cord-001835-0s7ok4uw	3675	51	)	)	-RRB-
cord-001835-0s7ok4uw	3675	52	by	by	IN
cord-001835-0s7ok4uw	3675	53	in	in	FW
cord-001835-0s7ok4uw	3675	54	vitro	vitro	FW
cord-001835-0s7ok4uw	3675	55	selection	selection	NN
cord-001835-0s7ok4uw	3675	56	using	use	VBG
cord-001835-0s7ok4uw	3675	57	cDNA	cdna	NN
cord-001835-0s7ok4uw	3675	58	display	display	NN
cord-001835-0s7ok4uw	3675	59	method	method	NN
cord-001835-0s7ok4uw	3675	60	.	.	.
cord-001835-0s7ok4uw	3676	1	The	the	DT
cord-001835-0s7ok4uw	3676	2	selected	selected	JJ
cord-001835-0s7ok4uw	3676	3	peptide	peptide	NN
cord-001835-0s7ok4uw	3676	4	LA	LA	NNP
cord-001835-0s7ok4uw	3676	5	peptide	peptide	NN
cord-001835-0s7ok4uw	3676	6	consists	consist	VBZ
cord-001835-0s7ok4uw	3676	7	of	of	IN
cord-001835-0s7ok4uw	3676	8	the	the	DT
cord-001835-0s7ok4uw	3676	9	N	n	CD
cord-001835-0s7ok4uw	3676	10	-	-	HYPH
cord-001835-0s7ok4uw	3676	11	terminal	terminal	NN
cord-001835-0s7ok4uw	3676	12	region	region	NN
cord-001835-0s7ok4uw	3676	13	(	(	-LRB-
cord-001835-0s7ok4uw	3676	14	hydrophobic	hydrophobic	NNP
cord-001835-0s7ok4uw	3676	15	)	)	-RRB-
cord-001835-0s7ok4uw	3676	16	and	and	CC
cord-001835-0s7ok4uw	3676	17	the	the	DT
cord-001835-0s7ok4uw	3676	18	C	C	NNP
cord-001835-0s7ok4uw	3676	19	-	-	HYPH
cord-001835-0s7ok4uw	3676	20	terminal	terminal	NN
cord-001835-0s7ok4uw	3676	21	region	region	NN
cord-001835-0s7ok4uw	3676	22	(	(	-LRB-
cord-001835-0s7ok4uw	3676	23	basic	basic	JJ
cord-001835-0s7ok4uw	3676	24	)	)	-RRB-
cord-001835-0s7ok4uw	3676	25	in	in	IN
cord-001835-0s7ok4uw	3676	26	a	a	DT
cord-001835-0s7ok4uw	3676	27	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	3676	28	manner	manner	NN
cord-001835-0s7ok4uw	3676	29	.	.	.
cord-001835-0s7ok4uw	3677	1	Thus	thus	RB
cord-001835-0s7ok4uw	3677	2	,	,	,
cord-001835-0s7ok4uw	3677	3	LA	LA	NNP
cord-001835-0s7ok4uw	3677	4	peptide	peptide	NN
cord-001835-0s7ok4uw	3677	5	was	be	VBD
cord-001835-0s7ok4uw	3677	6	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	3677	7	chemically	chemically	RB
cord-001835-0s7ok4uw	3677	8	and	and	CC
cord-001835-0s7ok4uw	3677	9	the	the	DT
cord-001835-0s7ok4uw	3677	10	interactions	interaction	NNS
cord-001835-0s7ok4uw	3677	11	between	between	IN
cord-001835-0s7ok4uw	3677	12	LA	LA	NNP
cord-001835-0s7ok4uw	3677	13	peptide	peptide	NN
cord-001835-0s7ok4uw	3677	14	and	and	CC
cord-001835-0s7ok4uw	3677	15	particular	particular	JJ
cord-001835-0s7ok4uw	3677	16	types	type	NNS
cord-001835-0s7ok4uw	3677	17	of	of	IN
cord-001835-0s7ok4uw	3677	18	liposomes	liposome	NNS
cord-001835-0s7ok4uw	3677	19	were	be	VBD
cord-001835-0s7ok4uw	3677	20	investigated	investigate	VBN
cord-001835-0s7ok4uw	3677	21	and	and	CC
cord-001835-0s7ok4uw	3677	22	confirmed	confirm	VBN
cord-001835-0s7ok4uw	3677	23	by	by	IN
cord-001835-0s7ok4uw	3677	24	confocal	confocal	JJ
cord-001835-0s7ok4uw	3677	25	laser	laser	NN
cord-001835-0s7ok4uw	3677	26	scanning	scanning	NN
cord-001835-0s7ok4uw	3677	27	microscopy	microscopy	NNS
cord-001835-0s7ok4uw	3677	28	.	.	.
cord-001835-0s7ok4uw	3678	1	Designing	design	VBG
cord-001835-0s7ok4uw	3678	2	of	of	IN
cord-001835-0s7ok4uw	3678	3	a	a	DT
cord-001835-0s7ok4uw	3678	4	novel	novel	JJ
cord-001835-0s7ok4uw	3678	5	platinum	platinum	NN
cord-001835-0s7ok4uw	3678	6	-	-	HYPH
cord-001835-0s7ok4uw	3678	7	binding	bind	VBG
cord-001835-0s7ok4uw	3678	8	amino	amino	NN
cord-001835-0s7ok4uw	3678	9	acid	acid	NN
cord-001835-0s7ok4uw	3678	10	sequence	sequence	NN
cord-001835-0s7ok4uw	3678	11	on	on	IN
cord-001835-0s7ok4uw	3678	12	a	a	DT
cord-001835-0s7ok4uw	3678	13	protein	protein	NN
cord-001835-0s7ok4uw	3678	14	surface	surface	NN
cord-001835-0s7ok4uw	3678	15	Asumi	Asumi	NNP
cord-001835-0s7ok4uw	3678	16	Kaji	Kaji	NNP
cord-001835-0s7ok4uw	3678	17	1	1	CD
cord-001835-0s7ok4uw	3678	18	,	,	,
cord-001835-0s7ok4uw	3678	19	Hiroya	Hiroya	NNP
cord-001835-0s7ok4uw	3678	20	Niiro	Niiro	NNP
cord-001835-0s7ok4uw	3678	21	1	1	CD
cord-001835-0s7ok4uw	3678	22	,	,	,
cord-001835-0s7ok4uw	3678	23	Satoshi	Satoshi	NNP
cord-001835-0s7ok4uw	3678	24	Akanuma	Akanuma	NNP
cord-001835-0s7ok4uw	3678	25	2	2	CD
cord-001835-0s7ok4uw	3678	26	,	,	,
cord-001835-0s7ok4uw	3678	27	Tetsuya	Tetsuya	NNP
cord-001835-0s7ok4uw	3678	28	Uchida	Uchida	NNP
cord-001835-0s7ok4uw	3678	29	1	1	CD
cord-001835-0s7ok4uw	3678	30	,	,	,
cord-001835-0s7ok4uw	3678	31	Akihiko	Akihiko	NNP
cord-001835-0s7ok4uw	3678	32	Yamagishi	Yamagishi	NNP
cord-001835-0s7ok4uw	3678	33	1	1	CD
cord-001835-0s7ok4uw	3678	34	1	1	CD
cord-001835-0s7ok4uw	3678	35	Designing	design	VBG
cord-001835-0s7ok4uw	3678	36	of	of	IN
cord-001835-0s7ok4uw	3678	37	a	a	DT
cord-001835-0s7ok4uw	3678	38	novel	novel	JJ
cord-001835-0s7ok4uw	3678	39	interaction	interaction	NN
cord-001835-0s7ok4uw	3678	40	between	between	IN
cord-001835-0s7ok4uw	3678	41	a	a	DT
cord-001835-0s7ok4uw	3678	42	metal	metal	NN
cord-001835-0s7ok4uw	3678	43	and	and	CC
cord-001835-0s7ok4uw	3678	44	a	a	DT
cord-001835-0s7ok4uw	3678	45	protein	protein	NN
cord-001835-0s7ok4uw	3678	46	is	be	VBZ
cord-001835-0s7ok4uw	3678	47	a	a	DT
cord-001835-0s7ok4uw	3678	48	key	key	NN
cord-001835-0s7ok4uw	3678	49	to	to	TO
cord-001835-0s7ok4uw	3678	50	create	create	VB
cord-001835-0s7ok4uw	3678	51	hybrid	hybrid	JJ
cord-001835-0s7ok4uw	3678	52	materials	material	NNS
cord-001835-0s7ok4uw	3678	53	between	between	IN
cord-001835-0s7ok4uw	3678	54	organic	organic	JJ
cord-001835-0s7ok4uw	3678	55	and	and	CC
cord-001835-0s7ok4uw	3678	56	inorganic	inorganic	JJ
cord-001835-0s7ok4uw	3678	57	materials	material	NNS
cord-001835-0s7ok4uw	3678	58	.	.	.
cord-001835-0s7ok4uw	3679	1	For	for	IN
cord-001835-0s7ok4uw	3679	2	example	example	NN
cord-001835-0s7ok4uw	3679	3	,	,	,
cord-001835-0s7ok4uw	3679	4	in	in	IN
cord-001835-0s7ok4uw	3679	5	a	a	DT
cord-001835-0s7ok4uw	3679	6	glucose	glucose	NN
cord-001835-0s7ok4uw	3679	7	biosensor	biosensor	NN
cord-001835-0s7ok4uw	3679	8	,	,	,
cord-001835-0s7ok4uw	3679	9	which	which	WDT
cord-001835-0s7ok4uw	3679	10	is	be	VBZ
cord-001835-0s7ok4uw	3679	11	widely	widely	RB
cord-001835-0s7ok4uw	3679	12	used	use	VBN
cord-001835-0s7ok4uw	3679	13	for	for	IN
cord-001835-0s7ok4uw	3679	14	measuring	measure	VBG
cord-001835-0s7ok4uw	3679	15	glucose	glucose	NN
cord-001835-0s7ok4uw	3679	16	concentration	concentration	NN
cord-001835-0s7ok4uw	3679	17	in	in	IN
cord-001835-0s7ok4uw	3679	18	blood	blood	NN
cord-001835-0s7ok4uw	3679	19	,	,	,
cord-001835-0s7ok4uw	3679	20	glucose	glucose	NN
cord-001835-0s7ok4uw	3679	21	oxidoreductase	oxidoreductase	NN
cord-001835-0s7ok4uw	3679	22	molecules	molecule	NNS
cord-001835-0s7ok4uw	3679	23	are	be	VBP
cord-001835-0s7ok4uw	3679	24	immobilized	immobilize	VBN
cord-001835-0s7ok4uw	3679	25	on	on	IN
cord-001835-0s7ok4uw	3679	26	a	a	DT
cord-001835-0s7ok4uw	3679	27	platinum	platinum	NN
cord-001835-0s7ok4uw	3679	28	electrode	electrode	NN
cord-001835-0s7ok4uw	3679	29	by	by	IN
cord-001835-0s7ok4uw	3679	30	polyacrylamide	polyacrylamide	NN
cord-001835-0s7ok4uw	3679	31	gel	gel	NN
cord-001835-0s7ok4uw	3679	32	.	.	.
cord-001835-0s7ok4uw	3680	1	A	a	DT
cord-001835-0s7ok4uw	3680	2	metal	metal	NN
cord-001835-0s7ok4uw	3680	3	-	-	HYPH
cord-001835-0s7ok4uw	3680	4	binding	bind	VBG
cord-001835-0s7ok4uw	3680	5	tags	tag	NNS
cord-001835-0s7ok4uw	3680	6	that	that	WDT
cord-001835-0s7ok4uw	3680	7	is	be	VBZ
cord-001835-0s7ok4uw	3680	8	added	add	VBN
cord-001835-0s7ok4uw	3680	9	to	to	IN
cord-001835-0s7ok4uw	3680	10	the	the	DT
cord-001835-0s7ok4uw	3680	11	N	N	NNP
cord-001835-0s7ok4uw	3680	12	-	-	:
cord-001835-0s7ok4uw	3680	13	or	or	CC
cord-001835-0s7ok4uw	3680	14	Cterminus	Cterminus	NNP
cord-001835-0s7ok4uw	3680	15	of	of	IN
cord-001835-0s7ok4uw	3680	16	a	a	DT
cord-001835-0s7ok4uw	3680	17	protein	protein	NN
cord-001835-0s7ok4uw	3680	18	is	be	VBZ
cord-001835-0s7ok4uw	3680	19	also	also	RB
cord-001835-0s7ok4uw	3680	20	used	use	VBN
cord-001835-0s7ok4uw	3680	21	for	for	IN
cord-001835-0s7ok4uw	3680	22	fix	fix	VB
cord-001835-0s7ok4uw	3680	23	the	the	DT
cord-001835-0s7ok4uw	3680	24	protein	protein	NN
cord-001835-0s7ok4uw	3680	25	to	to	IN
cord-001835-0s7ok4uw	3680	26	a	a	DT
cord-001835-0s7ok4uw	3680	27	metal	metal	NN
cord-001835-0s7ok4uw	3680	28	.	.	.
cord-001835-0s7ok4uw	3681	1	However	however	RB
cord-001835-0s7ok4uw	3681	2	,	,	,
cord-001835-0s7ok4uw	3681	3	a	a	DT
cord-001835-0s7ok4uw	3681	4	technique	technique	NN
cord-001835-0s7ok4uw	3681	5	to	to	TO
cord-001835-0s7ok4uw	3681	6	create	create	VB
cord-001835-0s7ok4uw	3681	7	a	a	DT
cord-001835-0s7ok4uw	3681	8	metal	metal	NN
cord-001835-0s7ok4uw	3681	9	binding	bind	VBG
cord-001835-0s7ok4uw	3681	10	site	site	NN
cord-001835-0s7ok4uw	3681	11	on	on	IN
cord-001835-0s7ok4uw	3681	12	a	a	DT
cord-001835-0s7ok4uw	3681	13	desired	desire	VBN
cord-001835-0s7ok4uw	3681	14	position	position	NN
cord-001835-0s7ok4uw	3681	15	of	of	IN
cord-001835-0s7ok4uw	3681	16	a	a	DT
cord-001835-0s7ok4uw	3681	17	protein	protein	NN
cord-001835-0s7ok4uw	3681	18	has	have	VBZ
cord-001835-0s7ok4uw	3681	19	not	not	RB
cord-001835-0s7ok4uw	3681	20	been	be	VBN
cord-001835-0s7ok4uw	3681	21	invent	invent	VB
cord-001835-0s7ok4uw	3681	22	.	.	.
cord-001835-0s7ok4uw	3682	1	If	if	IN
cord-001835-0s7ok4uw	3682	2	such	such	PDT
cord-001835-0s7ok4uw	3682	3	a	a	DT
cord-001835-0s7ok4uw	3682	4	technique	technique	NN
cord-001835-0s7ok4uw	3682	5	would	would	MD
cord-001835-0s7ok4uw	3682	6	be	be	VB
cord-001835-0s7ok4uw	3682	7	established	establish	VBN
cord-001835-0s7ok4uw	3682	8	,	,	,
cord-001835-0s7ok4uw	3682	9	the	the	DT
cord-001835-0s7ok4uw	3682	10	technique	technique	NN
cord-001835-0s7ok4uw	3682	11	would	would	MD
cord-001835-0s7ok4uw	3682	12	contribute	contribute	VB
cord-001835-0s7ok4uw	3682	13	to	to	IN
cord-001835-0s7ok4uw	3682	14	developing	develop	VBG
cord-001835-0s7ok4uw	3682	15	and	and	CC
cord-001835-0s7ok4uw	3682	16	improving	improve	VBG
cord-001835-0s7ok4uw	3682	17	biosensors	biosensor	NNS
cord-001835-0s7ok4uw	3682	18	and	and	CC
cord-001835-0s7ok4uw	3682	19	to	to	IN
cord-001835-0s7ok4uw	3682	20	producing	produce	VBG
cord-001835-0s7ok4uw	3682	21	new	new	JJ
cord-001835-0s7ok4uw	3682	22	bionanoelectronic	bionanoelectronic	NNP
cord-001835-0s7ok4uw	3682	23	materials	material	NNS
cord-001835-0s7ok4uw	3682	24	.	.	.
cord-001835-0s7ok4uw	3683	1	In	in	IN
cord-001835-0s7ok4uw	3683	2	this	this	DT
cord-001835-0s7ok4uw	3683	3	study	study	NN
cord-001835-0s7ok4uw	3683	4	,	,	,
cord-001835-0s7ok4uw	3683	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3683	6	created	create	VBD
cord-001835-0s7ok4uw	3683	7	a	a	DT
cord-001835-0s7ok4uw	3683	8	platinum	platinum	NN
cord-001835-0s7ok4uw	3683	9	-	-	HYPH
cord-001835-0s7ok4uw	3683	10	binding	bind	VBG
cord-001835-0s7ok4uw	3683	11	site	site	NN
cord-001835-0s7ok4uw	3683	12	on	on	IN
cord-001835-0s7ok4uw	3683	13	a	a	DT
cord-001835-0s7ok4uw	3683	14	loop	loop	NN
cord-001835-0s7ok4uw	3683	15	located	locate	VBN
cord-001835-0s7ok4uw	3683	16	at	at	IN
cord-001835-0s7ok4uw	3683	17	a	a	DT
cord-001835-0s7ok4uw	3683	18	protein	protein	NN
cord-001835-0s7ok4uw	3683	19	surface	surface	NN
cord-001835-0s7ok4uw	3683	20	.	.	.
cord-001835-0s7ok4uw	3684	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3684	2	used	use	VBD
cord-001835-0s7ok4uw	3684	3	an	an	DT
cord-001835-0s7ok4uw	3684	4	artificial	artificial	JJ
cord-001835-0s7ok4uw	3684	5	protein	protein	NN
cord-001835-0s7ok4uw	3684	6	,	,	,
cord-001835-0s7ok4uw	3684	7	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3684	8	,	,	,
cord-001835-0s7ok4uw	3684	9	that	that	WDT
cord-001835-0s7ok4uw	3684	10	had	have	VBD
cord-001835-0s7ok4uw	3684	11	been	be	VBN
cord-001835-0s7ok4uw	3684	12	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	3684	13	by	by	IN
cord-001835-0s7ok4uw	3684	14	connecting	connect	VBG
cord-001835-0s7ok4uw	3684	15	four	four	CD
cord-001835-0s7ok4uw	3684	16	identical	identical	JJ
cord-001835-0s7ok4uw	3684	17	alpha	alpha	NN
cord-001835-0s7ok4uw	3684	18	helices	helix	NNS
cord-001835-0s7ok4uw	3684	19	originated	originate	VBD
cord-001835-0s7ok4uw	3684	20	from	from	IN
cord-001835-0s7ok4uw	3684	21	the	the	DT
cord-001835-0s7ok4uw	3684	22	C	C	NNP
cord-001835-0s7ok4uw	3684	23	-	-	HYPH
cord-001835-0s7ok4uw	3684	24	terminal	terminal	NN
cord-001835-0s7ok4uw	3684	25	segment	segment	NN
cord-001835-0s7ok4uw	3684	26	of	of	IN
cord-001835-0s7ok4uw	3684	27	the	the	DT
cord-001835-0s7ok4uw	3684	28	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	3684	29	coli	coli	NNS
cord-001835-0s7ok4uw	3684	30	Lac	Lac	NNP
cord-001835-0s7ok4uw	3684	31	repressor	repressor	NN
cord-001835-0s7ok4uw	3684	32	with	with	IN
cord-001835-0s7ok4uw	3684	33	three	three	CD
cord-001835-0s7ok4uw	3684	34	identical	identical	JJ
cord-001835-0s7ok4uw	3684	35	loops	loop	NNS
cord-001835-0s7ok4uw	3684	36	.	.	.
cord-001835-0s7ok4uw	3685	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3685	2	randomized	randomize	VBD
cord-001835-0s7ok4uw	3685	3	the	the	DT
cord-001835-0s7ok4uw	3685	4	Ser	Ser	NNP
cord-001835-0s7ok4uw	3685	5	,	,	,
cord-001835-0s7ok4uw	3685	6	Gly	Gly	NNP
cord-001835-0s7ok4uw	3685	7	,	,	,
cord-001835-0s7ok4uw	3685	8	Gln	Gln	NNP
cord-001835-0s7ok4uw	3685	9	,	,	,
cord-001835-0s7ok4uw	3685	10	Gly	Gly	NNP
cord-001835-0s7ok4uw	3685	11	,	,	,
cord-001835-0s7ok4uw	3685	12	Gly	Gly	NNP
cord-001835-0s7ok4uw	3685	13	,	,	,
cord-001835-0s7ok4uw	3685	14	Ser	Ser	NNP
cord-001835-0s7ok4uw	3685	15	sequence	sequence	NN
cord-001835-0s7ok4uw	3685	16	within	within	IN
cord-001835-0s7ok4uw	3685	17	one	one	CD
cord-001835-0s7ok4uw	3685	18	of	of	IN
cord-001835-0s7ok4uw	3685	19	the	the	DT
cord-001835-0s7ok4uw	3685	20	inter	inter	JJ
cord-001835-0s7ok4uw	3685	21	-	-	JJ
cord-001835-0s7ok4uw	3685	22	helical	helical	JJ
cord-001835-0s7ok4uw	3685	23	loops	loop	NNS
cord-001835-0s7ok4uw	3685	24	and	and	CC
cord-001835-0s7ok4uw	3685	25	then	then	RB
cord-001835-0s7ok4uw	3685	26	selected	select	VBN
cord-001835-0s7ok4uw	3685	27	for	for	IN
cord-001835-0s7ok4uw	3685	28	binding	bind	VBG
cord-001835-0s7ok4uw	3685	29	to	to	IN
cord-001835-0s7ok4uw	3685	30	platinum	platinum	NN
cord-001835-0s7ok4uw	3685	31	by	by	IN
cord-001835-0s7ok4uw	3685	32	a	a	DT
cord-001835-0s7ok4uw	3685	33	T7	T7	NNP
cord-001835-0s7ok4uw	3685	34	phage	phage	NN
cord-001835-0s7ok4uw	3685	35	display	display	NN
cord-001835-0s7ok4uw	3685	36	system	system	NN
cord-001835-0s7ok4uw	3685	37	.	.	.
cord-001835-0s7ok4uw	3686	1	Most	Most	JJS
cord-001835-0s7ok4uw	3686	2	of	of	IN
cord-001835-0s7ok4uw	3686	3	the	the	DT
cord-001835-0s7ok4uw	3686	4	selected	select	VBN
cord-001835-0s7ok4uw	3686	5	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3686	6	variants	variant	NNS
cord-001835-0s7ok4uw	3686	7	contained	contain	VBD
cord-001835-0s7ok4uw	3686	8	the	the	DT
cord-001835-0s7ok4uw	3686	9	Tyr	Tyr	NNP
cord-001835-0s7ok4uw	3686	10	,	,	,
cord-001835-0s7ok4uw	3686	11	Lys	Lys	NNP
cord-001835-0s7ok4uw	3686	12	,	,	,
cord-001835-0s7ok4uw	3686	13	Arg	Arg	NNP
cord-001835-0s7ok4uw	3686	14	,	,	,
cord-001835-0s7ok4uw	3686	15	Gly	Gly	NNP
cord-001835-0s7ok4uw	3686	16	,	,	,
cord-001835-0s7ok4uw	3686	17	Tyr	Tyr	NNP
cord-001835-0s7ok4uw	3686	18	,	,	,
cord-001835-0s7ok4uw	3686	19	Lys	Lys	NNP
cord-001835-0s7ok4uw	3686	20	(	(	-LRB-
cord-001835-0s7ok4uw	3686	21	YKRGYK	YKRGYK	NNP
cord-001835-0s7ok4uw	3686	22	)	)	-RRB-
cord-001835-0s7ok4uw	3686	23	sequence	sequence	NN
cord-001835-0s7ok4uw	3686	24	in	in	IN
cord-001835-0s7ok4uw	3686	25	the	the	DT
cord-001835-0s7ok4uw	3686	26	randomized	randomized	JJ
cord-001835-0s7ok4uw	3686	27	segment	segment	NN
cord-001835-0s7ok4uw	3686	28	.	.	.
cord-001835-0s7ok4uw	3687	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3687	2	then	then	RB
cord-001835-0s7ok4uw	3687	3	evaluated	evaluate	VBD
cord-001835-0s7ok4uw	3687	4	the	the	DT
cord-001835-0s7ok4uw	3687	5	affinity	affinity	NN
cord-001835-0s7ok4uw	3687	6	of	of	IN
cord-001835-0s7ok4uw	3687	7	the	the	DT
cord-001835-0s7ok4uw	3687	8	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3687	9	variant	variant	NN
cord-001835-0s7ok4uw	3687	10	to	to	IN
cord-001835-0s7ok4uw	3687	11	platinum	platinum	NN
cord-001835-0s7ok4uw	3687	12	by	by	IN
cord-001835-0s7ok4uw	3687	13	means	mean	NNS
cord-001835-0s7ok4uw	3687	14	of	of	IN
cord-001835-0s7ok4uw	3687	15	Quartz	Quartz	NNP
cord-001835-0s7ok4uw	3687	16	Crystal	Crystal	NNP
cord-001835-0s7ok4uw	3687	17	Microbalance	Microbalance	NNP
cord-001835-0s7ok4uw	3687	18	analysis	analysis	NN
cord-001835-0s7ok4uw	3687	19	.	.	.
cord-001835-0s7ok4uw	3688	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3688	2	found	find	VBD
cord-001835-0s7ok4uw	3688	3	that	that	IN
cord-001835-0s7ok4uw	3688	4	the	the	DT
cord-001835-0s7ok4uw	3688	5	variant	variant	NN
cord-001835-0s7ok4uw	3688	6	binds	bind	VBZ
cord-001835-0s7ok4uw	3688	7	to	to	IN
cord-001835-0s7ok4uw	3688	8	platinum	platinum	NN
cord-001835-0s7ok4uw	3688	9	more	more	RBR
cord-001835-0s7ok4uw	3688	10	strongly	strongly	RB
cord-001835-0s7ok4uw	3688	11	than	than	IN
cord-001835-0s7ok4uw	3688	12	does	do	VBZ
cord-001835-0s7ok4uw	3688	13	the	the	DT
cord-001835-0s7ok4uw	3688	14	original	original	JJ
cord-001835-0s7ok4uw	3688	15	LARFH	LARFH	NNP
cord-001835-0s7ok4uw	3688	16	.	.	.
cord-001835-0s7ok4uw	3689	1	In	in	IN
cord-001835-0s7ok4uw	3689	2	the	the	DT
cord-001835-0s7ok4uw	3689	3	annual	annual	JJ
cord-001835-0s7ok4uw	3689	4	symposium	symposium	NN
cord-001835-0s7ok4uw	3689	5	,	,	,
cord-001835-0s7ok4uw	3689	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	3689	7	will	will	MD
cord-001835-0s7ok4uw	3689	8	also	also	RB
cord-001835-0s7ok4uw	3689	9	report	report	VB
cord-001835-0s7ok4uw	3689	10	about	about	IN
cord-001835-0s7ok4uw	3689	11	the	the	DT
cord-001835-0s7ok4uw	3689	12	affinity	affinity	NN
cord-001835-0s7ok4uw	3689	13	of	of	IN
cord-001835-0s7ok4uw	3689	14	the	the	DT
cord-001835-0s7ok4uw	3689	15	isolated	isolate	VBN
cord-001835-0s7ok4uw	3689	16	YKRGYK	ykrgyk	NN
cord-001835-0s7ok4uw	3689	17	sequence	sequence	NN
cord-001835-0s7ok4uw	3689	18	to	to	IN
cord-001835-0s7ok4uw	3689	19	platinum	platinum	NN
cord-001835-0s7ok4uw	3689	20	and	and	CC
cord-001835-0s7ok4uw	3689	21	about	about	IN
cord-001835-0s7ok4uw	3689	22	the	the	DT
cord-001835-0s7ok4uw	3689	23	crucial	crucial	JJ
cord-001835-0s7ok4uw	3689	24	role	role	NN
cord-001835-0s7ok4uw	3689	25	of	of	IN
cord-001835-0s7ok4uw	3689	26	the	the	DT
cord-001835-0s7ok4uw	3689	27	first	first	JJ
cord-001835-0s7ok4uw	3689	28	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	3689	29	in	in	IN
cord-001835-0s7ok4uw	3689	30	binding	bind	VBG
cord-001835-0s7ok4uw	3689	31	to	to	IN
cord-001835-0s7ok4uw	3689	32	platinum	platinum	NN
cord-001835-0s7ok4uw	3689	33	.	.	.
cord-001835-0s7ok4uw	3690	1	Engineering	engineering	NN
cord-001835-0s7ok4uw	3690	2	of	of	IN
cord-001835-0s7ok4uw	3690	3	an	an	DT
cord-001835-0s7ok4uw	3690	4	isolated	isolated	JJ
cord-001835-0s7ok4uw	3690	5	p110a	p110a	CD
cord-001835-0s7ok4uw	3690	6	subunit	subunit	NN
cord-001835-0s7ok4uw	3690	7	of	of	IN
cord-001835-0s7ok4uw	3690	8	PI3Ka	PI3Ka	NNP
cord-001835-0s7ok4uw	3690	9	permits	permit	VBZ
cord-001835-0s7ok4uw	3690	10	crystallization	crystallization	NN
cord-001835-0s7ok4uw	3690	11	and	and	CC
cord-001835-0s7ok4uw	3690	12	provides	provide	VBZ
cord-001835-0s7ok4uw	3690	13	a	a	DT
cord-001835-0s7ok4uw	3690	14	platform	platform	NN
cord-001835-0s7ok4uw	3690	15	for	for	IN
cord-001835-0s7ok4uw	3690	16	structure	structure	NN
cord-001835-0s7ok4uw	3690	17	-	-	HYPH
cord-001835-0s7ok4uw	3690	18	based	base	VBN
cord-001835-0s7ok4uw	3690	19	drug	drug	NN
cord-001835-0s7ok4uw	3690	20	design	design	NN
cord-001835-0s7ok4uw	3691	1	PI3Ka	PI3Ka	NNP
cord-001835-0s7ok4uw	3691	2	remains	remain	VBZ
cord-001835-0s7ok4uw	3691	3	an	an	DT
cord-001835-0s7ok4uw	3691	4	attractive	attractive	JJ
cord-001835-0s7ok4uw	3691	5	target	target	NN
cord-001835-0s7ok4uw	3691	6	for	for	IN
cord-001835-0s7ok4uw	3691	7	development	development	NN
cord-001835-0s7ok4uw	3691	8	of	of	IN
cord-001835-0s7ok4uw	3691	9	anticancer	anticancer	JJ
cord-001835-0s7ok4uw	3691	10	targeted	target	VBN
cord-001835-0s7ok4uw	3691	11	therapy	therapy	NN
cord-001835-0s7ok4uw	3691	12	.	.	.
cord-001835-0s7ok4uw	3692	1	A	a	DT
cord-001835-0s7ok4uw	3692	2	number	number	NN
cord-001835-0s7ok4uw	3692	3	of	of	IN
cord-001835-0s7ok4uw	3692	4	p110a	p110a	CD
cord-001835-0s7ok4uw	3692	5	crystal	crystal	NN
cord-001835-0s7ok4uw	3692	6	structures	structure	NNS
cord-001835-0s7ok4uw	3692	7	in	in	IN
cord-001835-0s7ok4uw	3692	8	complex	complex	NN
cord-001835-0s7ok4uw	3692	9	with	with	IN
cord-001835-0s7ok4uw	3692	10	the	the	DT
cord-001835-0s7ok4uw	3692	11	nSH2-iSH2	nSH2-iSH2	VBN
cord-001835-0s7ok4uw	3692	12	fragment	fragment	NN
cord-001835-0s7ok4uw	3692	13	of	of	IN
cord-001835-0s7ok4uw	3692	14	p85	p85	JJ
cord-001835-0s7ok4uw	3692	15	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	3692	16	subunit	subunit	NN
cord-001835-0s7ok4uw	3692	17	have	have	VBP
cord-001835-0s7ok4uw	3692	18	been	be	VBN
cord-001835-0s7ok4uw	3692	19	reported	report	VBN
cord-001835-0s7ok4uw	3692	20	,	,	,
cord-001835-0s7ok4uw	3692	21	including	include	VBG
cord-001835-0s7ok4uw	3692	22	a	a	DT
cord-001835-0s7ok4uw	3692	23	few	few	JJ
cord-001835-0s7ok4uw	3692	24	small	small	JJ
cord-001835-0s7ok4uw	3692	25	molecule	molecule	NN
cord-001835-0s7ok4uw	3692	26	co	co	NN
cord-001835-0s7ok4uw	3692	27	-	-	JJ
cord-001835-0s7ok4uw	3692	28	crystal	crystal	JJ
cord-001835-0s7ok4uw	3692	29	structures	structure	NNS
cord-001835-0s7ok4uw	3692	30	,	,	,
cord-001835-0s7ok4uw	3692	31	but	but	CC
cord-001835-0s7ok4uw	3692	32	the	the	DT
cord-001835-0s7ok4uw	3692	33	utilization	utilization	NN
cord-001835-0s7ok4uw	3692	34	of	of	IN
cord-001835-0s7ok4uw	3692	35	this	this	DT
cord-001835-0s7ok4uw	3692	36	crystal	crystal	NN
cord-001835-0s7ok4uw	3692	37	form	form	NN
cord-001835-0s7ok4uw	3692	38	is	be	VBZ
cord-001835-0s7ok4uw	3692	39	limited	limit	VBN
cord-001835-0s7ok4uw	3692	40	by	by	IN
cord-001835-0s7ok4uw	3692	41	low	low	JJ
cord-001835-0s7ok4uw	3692	42	diffraction	diffraction	NN
cord-001835-0s7ok4uw	3692	43	resolution	resolution	NN
cord-001835-0s7ok4uw	3692	44	and	and	CC
cord-001835-0s7ok4uw	3692	45	a	a	DT
cord-001835-0s7ok4uw	3692	46	crystal	crystal	NN
cord-001835-0s7ok4uw	3692	47	packing	packing	NN
cord-001835-0s7ok4uw	3692	48	artifact	artifact	NN
cord-001835-0s7ok4uw	3692	49	that	that	WDT
cord-001835-0s7ok4uw	3692	50	partially	partially	RB
cord-001835-0s7ok4uw	3692	51	blocks	block	VBZ
cord-001835-0s7ok4uw	3692	52	the	the	DT
cord-001835-0s7ok4uw	3692	53	ATP	ATP	NNP
cord-001835-0s7ok4uw	3692	54	binding	binding	NN
cord-001835-0s7ok4uw	3692	55	site	site	NN
cord-001835-0s7ok4uw	3692	56	.	.	.
cord-001835-0s7ok4uw	3693	1	Taking	take	VBG
cord-001835-0s7ok4uw	3693	2	advantage	advantage	NN
cord-001835-0s7ok4uw	3693	3	of	of	IN
cord-001835-0s7ok4uw	3693	4	recent	recent	JJ
cord-001835-0s7ok4uw	3693	5	data	datum	NNS
cord-001835-0s7ok4uw	3693	6	on	on	IN
cord-001835-0s7ok4uw	3693	7	the	the	DT
cord-001835-0s7ok4uw	3693	8	functional	functional	JJ
cord-001835-0s7ok4uw	3693	9	characterization	characterization	NN
cord-001835-0s7ok4uw	3693	10	of	of	IN
cord-001835-0s7ok4uw	3693	11	the	the	DT
cord-001835-0s7ok4uw	3693	12	lipid	lipid	NN
cord-001835-0s7ok4uw	3693	13	binding	bind	VBG
cord-001835-0s7ok4uw	3693	14	properties	property	NNS
cord-001835-0s7ok4uw	3693	15	of	of	IN
cord-001835-0s7ok4uw	3693	16	p110a	p110a	CD
cord-001835-0s7ok4uw	3693	17	,	,	,
cord-001835-0s7ok4uw	3693	18	we	-PRON-	PRP
cord-001835-0s7ok4uw	3693	19	designed	design	VBD
cord-001835-0s7ok4uw	3693	20	a	a	DT
cord-001835-0s7ok4uw	3693	21	set	set	NN
cord-001835-0s7ok4uw	3693	22	of	of	IN
cord-001835-0s7ok4uw	3693	23	novel	novel	JJ
cord-001835-0s7ok4uw	3693	24	constructs	construct	NNS
cord-001835-0s7ok4uw	3693	25	allowing	allow	VBG
cord-001835-0s7ok4uw	3693	26	production	production	NN
cord-001835-0s7ok4uw	3693	27	of	of	IN
cord-001835-0s7ok4uw	3693	28	isolated	isolate	VBN
cord-001835-0s7ok4uw	3693	29	stable	stable	JJ
cord-001835-0s7ok4uw	3693	30	p110a	p110a	CD
cord-001835-0s7ok4uw	3693	31	subunit	subunit	NN
cord-001835-0s7ok4uw	3693	32	missing	miss	VBG
cord-001835-0s7ok4uw	3693	33	the	the	DT
cord-001835-0s7ok4uw	3693	34	Adapter	Adapter	NNP
cord-001835-0s7ok4uw	3693	35	Binding	Binding	NNP
cord-001835-0s7ok4uw	3693	36	Domain	Domain	NNP
cord-001835-0s7ok4uw	3693	37	(	(	-LRB-
cord-001835-0s7ok4uw	3693	38	ABD	ABD	NNP
cord-001835-0s7ok4uw	3693	39	)	)	-RRB-
cord-001835-0s7ok4uw	3693	40	and	and	CC
cord-001835-0s7ok4uw	3693	41	lacking	lack	VBG
cord-001835-0s7ok4uw	3693	42	or	or	CC
cord-001835-0s7ok4uw	3693	43	featuring	feature	VBG
cord-001835-0s7ok4uw	3693	44	a	a	DT
cord-001835-0s7ok4uw	3693	45	modified	modify	VBN
cord-001835-0s7ok4uw	3693	46	C	c	NN
cord-001835-0s7ok4uw	3693	47	-	-	HYPH
cord-001835-0s7ok4uw	3693	48	terminal	terminal	NN
cord-001835-0s7ok4uw	3693	49	lipid	lipid	NN
cord-001835-0s7ok4uw	3693	50	binding	bind	VBG
cord-001835-0s7ok4uw	3693	51	motif	motif	NN
cord-001835-0s7ok4uw	3693	52	.	.	.
cord-001835-0s7ok4uw	3694	1	While	while	IN
cord-001835-0s7ok4uw	3694	2	this	this	DT
cord-001835-0s7ok4uw	3694	3	protein	protein	NN
cord-001835-0s7ok4uw	3694	4	is	be	VBZ
cord-001835-0s7ok4uw	3694	5	not	not	RB
cord-001835-0s7ok4uw	3694	6	catalytically	catalytically	RB
cord-001835-0s7ok4uw	3694	7	competent	competent	JJ
cord-001835-0s7ok4uw	3694	8	to	to	TO
cord-001835-0s7ok4uw	3694	9	phosphorylate	phosphorylate	VB
cord-001835-0s7ok4uw	3694	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3694	11	substrate	substrate	NN
cord-001835-0s7ok4uw	3694	12	PIP2	PIP2	NNP
cord-001835-0s7ok4uw	3694	13	,	,	,
cord-001835-0s7ok4uw	3694	14	it	-PRON-	PRP
cord-001835-0s7ok4uw	3694	15	retains	retain	VBZ
cord-001835-0s7ok4uw	3694	16	ligand	ligand	NN
cord-001835-0s7ok4uw	3694	17	binding	bind	VBG
cord-001835-0s7ok4uw	3694	18	properties	property	NNS
cord-001835-0s7ok4uw	3694	19	as	as	IN
cord-001835-0s7ok4uw	3694	20	indicated	indicate	VBN
cord-001835-0s7ok4uw	3694	21	by	by	IN
cord-001835-0s7ok4uw	3694	22	direct	direct	JJ
cord-001835-0s7ok4uw	3694	23	binding	binding	NN
cord-001835-0s7ok4uw	3694	24	studies	study	NNS
cord-001835-0s7ok4uw	3694	25	with	with	IN
cord-001835-0s7ok4uw	3694	26	a	a	DT
cord-001835-0s7ok4uw	3694	27	pan	pan	JJ
cord-001835-0s7ok4uw	3694	28	-	-	HYPH
cord-001835-0s7ok4uw	3694	29	PI3Ka	PI3Ka	NNP
cord-001835-0s7ok4uw	3694	30	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	3694	31	.	.	.
cord-001835-0s7ok4uw	3695	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	3695	2	,	,	,
cord-001835-0s7ok4uw	3695	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3695	4	determined	determine	VBD
cord-001835-0s7ok4uw	3695	5	apo	apo	NNP
cord-001835-0s7ok4uw	3695	6	and	and	CC
cord-001835-0s7ok4uw	3695	7	PF-04691502	PF-04691502	NNP
cord-001835-0s7ok4uw	3695	8	bound	bind	VBN
cord-001835-0s7ok4uw	3695	9	crystal	crystal	NN
cord-001835-0s7ok4uw	3695	10	structures	structure	NNS
cord-001835-0s7ok4uw	3695	11	of	of	IN
cord-001835-0s7ok4uw	3695	12	the	the	DT
cord-001835-0s7ok4uw	3695	13	p110a	p110a	CD
cord-001835-0s7ok4uw	3695	14	(	(	-LRB-
cord-001835-0s7ok4uw	3695	15	105	105	CD
cord-001835-0s7ok4uw	3695	16	-	-	SYM
cord-001835-0s7ok4uw	3695	17	1048	1048	CD
cord-001835-0s7ok4uw	3695	18	)	)	-RRB-
cord-001835-0s7ok4uw	3695	19	subunit	subunit	NN
cord-001835-0s7ok4uw	3695	20	at	at	IN
cord-001835-0s7ok4uw	3695	21	2.65	2.65	CD
cord-001835-0s7ok4uw	3695	22	Å	å	NN
cord-001835-0s7ok4uw	3695	23	and	and	CC
cord-001835-0s7ok4uw	3695	24	2.85	2.85	CD
cord-001835-0s7ok4uw	3695	25	Å	å	NN
cord-001835-0s7ok4uw	3695	26	respectively	respectively	RB
cord-001835-0s7ok4uw	3695	27	.	.	.
cord-001835-0s7ok4uw	3696	1	Comparison	comparison	NN
cord-001835-0s7ok4uw	3696	2	of	of	IN
cord-001835-0s7ok4uw	3696	3	isolated	isolate	VBN
cord-001835-0s7ok4uw	3696	4	p110a	p110a	''
cord-001835-0s7ok4uw	3696	5	(	(	-LRB-
cord-001835-0s7ok4uw	3696	6	105	105	CD
cord-001835-0s7ok4uw	3696	7	-	-	SYM
cord-001835-0s7ok4uw	3696	8	1048	1048	CD
cord-001835-0s7ok4uw	3696	9	)	)	-RRB-
cord-001835-0s7ok4uw	3696	10	with	with	IN
cord-001835-0s7ok4uw	3696	11	the	the	DT
cord-001835-0s7ok4uw	3696	12	p110a	p110a	CD
cord-001835-0s7ok4uw	3696	13	/	/	SYM
cord-001835-0s7ok4uw	3696	14	p85	p85	NN
cord-001835-0s7ok4uw	3696	15	complex	complex	NN
cord-001835-0s7ok4uw	3696	16	reveals	reveal	VBZ
cord-001835-0s7ok4uw	3696	17	a	a	DT
cord-001835-0s7ok4uw	3696	18	high	high	JJ
cord-001835-0s7ok4uw	3696	19	degree	degree	NN
cord-001835-0s7ok4uw	3696	20	of	of	IN
cord-001835-0s7ok4uw	3696	21	structural	structural	JJ
cord-001835-0s7ok4uw	3696	22	similarity	similarity	NN
cord-001835-0s7ok4uw	3696	23	,	,	,
cord-001835-0s7ok4uw	3696	24	which	which	WDT
cord-001835-0s7ok4uw	3696	25	validates	validate	VBZ
cord-001835-0s7ok4uw	3696	26	suitability	suitability	NN
cord-001835-0s7ok4uw	3696	27	of	of	IN
cord-001835-0s7ok4uw	3696	28	this	this	DT
cord-001835-0s7ok4uw	3696	29	catalytically	catalytically	RB
cord-001835-0s7ok4uw	3696	30	inactive	inactive	JJ
cord-001835-0s7ok4uw	3696	31	p110a	p110a	''
cord-001835-0s7ok4uw	3696	32	for	for	IN
cord-001835-0s7ok4uw	3696	33	iterative	iterative	JJ
cord-001835-0s7ok4uw	3696	34	SBDD	SBDD	NNP
cord-001835-0s7ok4uw	3696	35	.	.	.
cord-001835-0s7ok4uw	3697	1	Importantly	importantly	RB
cord-001835-0s7ok4uw	3697	2	,	,	,
cord-001835-0s7ok4uw	3697	3	this	this	DT
cord-001835-0s7ok4uw	3697	4	crystal	crystal	NN
cord-001835-0s7ok4uw	3697	5	form	form	NN
cord-001835-0s7ok4uw	3697	6	of	of	IN
cord-001835-0s7ok4uw	3697	7	p110a	p110a	PRP
cord-001835-0s7ok4uw	3697	8	readily	readily	RB
cord-001835-0s7ok4uw	3697	9	accommodates	accommodate	VBZ
cord-001835-0s7ok4uw	3697	10	the	the	DT
cord-001835-0s7ok4uw	3697	11	binding	binding	NN
cord-001835-0s7ok4uw	3697	12	of	of	IN
cord-001835-0s7ok4uw	3697	13	non	non	JJ
cord-001835-0s7ok4uw	3697	14	-	-	JJ
cord-001835-0s7ok4uw	3697	15	covalent	covalent	JJ
cord-001835-0s7ok4uw	3697	16	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	3697	17	by	by	IN
cord-001835-0s7ok4uw	3697	18	means	mean	NNS
cord-001835-0s7ok4uw	3697	19	of	of	IN
cord-001835-0s7ok4uw	3697	20	a	a	DT
cord-001835-0s7ok4uw	3697	21	fully	fully	RB
cord-001835-0s7ok4uw	3697	22	accessible	accessible	JJ
cord-001835-0s7ok4uw	3697	23	ATP	ATP	NNP
cord-001835-0s7ok4uw	3697	24	site	site	NN
cord-001835-0s7ok4uw	3697	25	.	.	.
cord-001835-0s7ok4uw	3698	1	The	the	DT
cord-001835-0s7ok4uw	3698	2	strategy	strategy	NN
cord-001835-0s7ok4uw	3698	3	presented	present	VBN
cord-001835-0s7ok4uw	3698	4	here	here	RB
cord-001835-0s7ok4uw	3698	5	can	can	MD
cord-001835-0s7ok4uw	3698	6	be	be	VB
cord-001835-0s7ok4uw	3698	7	also	also	RB
cord-001835-0s7ok4uw	3698	8	applied	apply	VBN
cord-001835-0s7ok4uw	3698	9	to	to	IN
cord-001835-0s7ok4uw	3698	10	structural	structural	JJ
cord-001835-0s7ok4uw	3698	11	studies	study	NNS
cord-001835-0s7ok4uw	3698	12	of	of	IN
cord-001835-0s7ok4uw	3698	13	other	other	JJ
cord-001835-0s7ok4uw	3698	14	members	member	NNS
cord-001835-0s7ok4uw	3698	15	of	of	IN
cord-001835-0s7ok4uw	3698	16	PI3KIA	pi3kia	NN
cord-001835-0s7ok4uw	3698	17	family	family	NN
cord-001835-0s7ok4uw	3698	18	.	.	.
cord-001835-0s7ok4uw	3699	1	Identification	identification	NN
cord-001835-0s7ok4uw	3699	2	of	of	IN
cord-001835-0s7ok4uw	3699	3	structural	structural	JJ
cord-001835-0s7ok4uw	3699	4	determinants	determinant	NNS
cord-001835-0s7ok4uw	3699	5	involved	involve	VBN
cord-001835-0s7ok4uw	3699	6	in	in	IN
cord-001835-0s7ok4uw	3699	7	the	the	DT
cord-001835-0s7ok4uw	3699	8	differential	differential	JJ
cord-001835-0s7ok4uw	3699	9	conformational	conformational	JJ
cord-001835-0s7ok4uw	3699	10	changes	change	NNS
cord-001835-0s7ok4uw	3699	11	of	of	IN
cord-001835-0s7ok4uw	3699	12	EF	ef	NN
cord-001835-0s7ok4uw	3699	13	-	-	HYPH
cord-001835-0s7ok4uw	3699	14	hand	hand	NN
cord-001835-0s7ok4uw	3699	15	modules	module	NNS
cord-001835-0s7ok4uw	3699	16	Emma	Emma	NNP
cord-001835-0s7ok4uw	3699	17	Liliana	Liliana	NNP
cord-001835-0s7ok4uw	3699	18	Arevalo	Arevalo	NNP
cord-001835-0s7ok4uw	3699	19	Salina	Salina	NNP
cord-001835-0s7ok4uw	3699	20	1	1	CD
cord-001835-0s7ok4uw	3699	21	,	,	,
cord-001835-0s7ok4uw	3699	22	Joel	Joel	NNP
cord-001835-0s7ok4uw	3699	23	Osuna	Osuna	NNP
cord-001835-0s7ok4uw	3699	24	Quintero	Quintero	NNP
cord-001835-0s7ok4uw	3699	25	1	1	CD
cord-001835-0s7ok4uw	3699	26	,	,	,
cord-001835-0s7ok4uw	3699	27	Humberto	Humberto	NNP
cord-001835-0s7ok4uw	3699	28	Flores	Flores	NNP
cord-001835-0s7ok4uw	3699	29	Soto	Soto	NNP
cord-001835-0s7ok4uw	3699	30	1	1	CD
cord-001835-0s7ok4uw	3699	31	,	,	,
cord-001835-0s7ok4uw	3700	1	Gloria	Gloria	NNP
cord-001835-0s7ok4uw	3700	2	Saab	Saab	NNP
cord-001835-0s7ok4uw	3700	3	Rinc	Rinc	NNP
cord-001835-0s7ok4uw	3700	4	on	on	IN
cord-001835-0s7ok4uw	3700	5	1	1	CD
cord-001835-0s7ok4uw	3700	6	1	1	CD
cord-001835-0s7ok4uw	3700	7	Instituto	Instituto	NNP
cord-001835-0s7ok4uw	3700	8	de	de	NNP
cord-001835-0s7ok4uw	3700	9	Biotecnolog	Biotecnolog	NNP
cord-001835-0s7ok4uw	3700	10	ıa	ıa	NNS
cord-001835-0s7ok4uw	3700	11	,	,	,
cord-001835-0s7ok4uw	3700	12	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	3700	13	Nacional	Nacional	NNP
cord-001835-0s7ok4uw	3700	14	Aut	Aut	NNP
cord-001835-0s7ok4uw	3700	15	onoma	onoma	NN
cord-001835-0s7ok4uw	3700	16	de	de	NNP
cord-001835-0s7ok4uw	3700	17	M	M	NNP
cord-001835-0s7ok4uw	3700	18	exico	exico	NN
cord-001835-0s7ok4uw	3700	19	Identification	Identification	NNP
cord-001835-0s7ok4uw	3700	20	of	of	IN
cord-001835-0s7ok4uw	3700	21	structural	structural	JJ
cord-001835-0s7ok4uw	3700	22	determinants	determinant	NNS
cord-001835-0s7ok4uw	3700	23	involved	involve	VBN
cord-001835-0s7ok4uw	3700	24	in	in	IN
cord-001835-0s7ok4uw	3700	25	the	the	DT
cord-001835-0s7ok4uw	3700	26	differential	differential	JJ
cord-001835-0s7ok4uw	3700	27	conformational	conformational	JJ
cord-001835-0s7ok4uw	3700	28	changes	change	NNS
cord-001835-0s7ok4uw	3700	29	of	of	IN
cord-001835-0s7ok4uw	3700	30	EF	ef	NN
cord-001835-0s7ok4uw	3700	31	-	-	HYPH
cord-001835-0s7ok4uw	3700	32	hand	hand	NN
cord-001835-0s7ok4uw	3700	33	modules	module	NNS
cord-001835-0s7ok4uw	3700	34	Calcium	calcium	NN
cord-001835-0s7ok4uw	3700	35	signals	signal	NNS
cord-001835-0s7ok4uw	3700	36	are	be	VBP
cord-001835-0s7ok4uw	3700	37	regulated	regulate	VBN
cord-001835-0s7ok4uw	3700	38	by	by	IN
cord-001835-0s7ok4uw	3700	39	several	several	JJ
cord-001835-0s7ok4uw	3700	40	proteins	protein	NNS
cord-001835-0s7ok4uw	3700	41	,	,	,
cord-001835-0s7ok4uw	3700	42	most	most	JJS
cord-001835-0s7ok4uw	3700	43	of	of	IN
cord-001835-0s7ok4uw	3700	44	which	which	WDT
cord-001835-0s7ok4uw	3700	45	belong	belong	VBP
cord-001835-0s7ok4uw	3700	46	to	to	IN
cord-001835-0s7ok4uw	3700	47	the	the	DT
cord-001835-0s7ok4uw	3700	48	EF	EF	NNP
cord-001835-0s7ok4uw	3700	49	-	-	HYPH
cord-001835-0s7ok4uw	3700	50	hand	hand	NN
cord-001835-0s7ok4uw	3700	51	superfamily	superfamily	NN
cord-001835-0s7ok4uw	3700	52	.	.	.
cord-001835-0s7ok4uw	3701	1	The	the	DT
cord-001835-0s7ok4uw	3701	2	EF	EF	NNP
cord-001835-0s7ok4uw	3701	3	-	-	HYPH
cord-001835-0s7ok4uw	3701	4	hand	hand	NN
cord-001835-0s7ok4uw	3701	5	motif	motif	NN
cord-001835-0s7ok4uw	3701	6	is	be	VBZ
cord-001835-0s7ok4uw	3701	7	formed	form	VBN
cord-001835-0s7ok4uw	3701	8	by	by	IN
cord-001835-0s7ok4uw	3701	9	a	a	DT
cord-001835-0s7ok4uw	3701	10	helix	helix	NN
cord-001835-0s7ok4uw	3701	11	-	-	HYPH
cord-001835-0s7ok4uw	3701	12	loop	loop	NN
cord-001835-0s7ok4uw	3701	13	-	-	HYPH
cord-001835-0s7ok4uw	3701	14	helix	helix	NN
cord-001835-0s7ok4uw	3701	15	that	that	WDT
cord-001835-0s7ok4uw	3701	16	binds	bind	VBZ
cord-001835-0s7ok4uw	3701	17	calcium	calcium	NN
cord-001835-0s7ok4uw	3701	18	through	through	IN
cord-001835-0s7ok4uw	3701	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3701	20	loop1	loop1	NN
cord-001835-0s7ok4uw	3701	21	.	.	.
cord-001835-0s7ok4uw	3702	1	These	these	DT
cord-001835-0s7ok4uw	3702	2	motifs	motif	NNS
cord-001835-0s7ok4uw	3702	3	occur	occur	VBP
cord-001835-0s7ok4uw	3702	4	in	in	IN
cord-001835-0s7ok4uw	3702	5	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	3702	6	pairs	pair	NNS
cord-001835-0s7ok4uw	3702	7	,	,	,
cord-001835-0s7ok4uw	3702	8	forming	form	VBG
cord-001835-0s7ok4uw	3702	9	a	a	DT
cord-001835-0s7ok4uw	3702	10	single	single	JJ
cord-001835-0s7ok4uw	3702	11	globular	globular	JJ
cord-001835-0s7ok4uw	3702	12	domain	domain	NN
cord-001835-0s7ok4uw	3702	13	which	which	WDT
cord-001835-0s7ok4uw	3702	14	is	be	VBZ
cord-001835-0s7ok4uw	3702	15	the	the	DT
cord-001835-0s7ok4uw	3702	16	basic	basic	JJ
cord-001835-0s7ok4uw	3702	17	structural	structural	JJ
cord-001835-0s7ok4uw	3702	18	and	and	CC
cord-001835-0s7ok4uw	3702	19	functional	functional	JJ
cord-001835-0s7ok4uw	3702	20	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	3702	21	binding	bind	VBG
cord-001835-0s7ok4uw	3702	22	unit	unit	NN
cord-001835-0s7ok4uw	3702	23	.	.	.
cord-001835-0s7ok4uw	3703	1	The	the	DT
cord-001835-0s7ok4uw	3703	2	proteins	protein	NNS
cord-001835-0s7ok4uw	3703	3	in	in	IN
cord-001835-0s7ok4uw	3703	4	this	this	DT
cord-001835-0s7ok4uw	3703	5	family	family	NN
cord-001835-0s7ok4uw	3703	6	can	can	MD
cord-001835-0s7ok4uw	3703	7	be	be	VB
cord-001835-0s7ok4uw	3703	8	classified	classify	VBN
cord-001835-0s7ok4uw	3703	9	as	as	IN
cord-001835-0s7ok4uw	3703	10	calcium	calcium	NN
cord-001835-0s7ok4uw	3703	11	sensors	sensor	NNS
cord-001835-0s7ok4uw	3703	12	or	or	CC
cord-001835-0s7ok4uw	3703	13	modulators	modulator	NNS
cord-001835-0s7ok4uw	3703	14	,	,	,
cord-001835-0s7ok4uw	3703	15	according	accord	VBG
cord-001835-0s7ok4uw	3703	16	with	with	IN
cord-001835-0s7ok4uw	3703	17	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3703	18	function	function	NN
cord-001835-0s7ok4uw	3703	19	.	.	.
cord-001835-0s7ok4uw	3704	1	The	the	DT
cord-001835-0s7ok4uw	3704	2	first	first	JJ
cord-001835-0s7ok4uw	3704	3	group	group	NN
cord-001835-0s7ok4uw	3704	4	undergoes	undergo	VBZ
cord-001835-0s7ok4uw	3704	5	a	a	DT
cord-001835-0s7ok4uw	3704	6	major	major	JJ
cord-001835-0s7ok4uw	3704	7	conformational	conformational	JJ
cord-001835-0s7ok4uw	3704	8	change	change	NN
cord-001835-0s7ok4uw	3704	9	upon	upon	IN
cord-001835-0s7ok4uw	3704	10	calcium	calcium	NN
cord-001835-0s7ok4uw	3704	11	binding	binding	NN
cord-001835-0s7ok4uw	3704	12	,	,	,
cord-001835-0s7ok4uw	3704	13	while	while	IN
cord-001835-0s7ok4uw	3704	14	the	the	DT
cord-001835-0s7ok4uw	3704	15	second	second	JJ
cord-001835-0s7ok4uw	3704	16	one	one	NN
cord-001835-0s7ok4uw	3704	17	remains	remain	VBZ
cord-001835-0s7ok4uw	3704	18	practically	practically	RB
cord-001835-0s7ok4uw	3704	19	unchanged1,2	unchanged1,2	CD
cord-001835-0s7ok4uw	3704	20	.	.	.
cord-001835-0s7ok4uw	3705	1	To	to	TO
cord-001835-0s7ok4uw	3705	2	explain	explain	VB
cord-001835-0s7ok4uw	3705	3	the	the	DT
cord-001835-0s7ok4uw	3705	4	biophysics	biophysic	NNS
cord-001835-0s7ok4uw	3705	5	behind	behind	IN
cord-001835-0s7ok4uw	3705	6	the	the	DT
cord-001835-0s7ok4uw	3705	7	different	different	JJ
cord-001835-0s7ok4uw	3705	8	behavior	behavior	NN
cord-001835-0s7ok4uw	3705	9	of	of	IN
cord-001835-0s7ok4uw	3705	10	these	these	DT
cord-001835-0s7ok4uw	3705	11	proteins	protein	NNS
cord-001835-0s7ok4uw	3705	12	upon	upon	IN
cord-001835-0s7ok4uw	3705	13	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	3706	1	binding	bind	VBG
cord-001835-0s7ok4uw	3706	2	,	,	,
cord-001835-0s7ok4uw	3706	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3706	4	have	have	VBP
cord-001835-0s7ok4uw	3706	5	sought	seek	VBN
cord-001835-0s7ok4uw	3706	6	to	to	TO
cord-001835-0s7ok4uw	3706	7	identify	identify	VB
cord-001835-0s7ok4uw	3706	8	structural	structural	JJ
cord-001835-0s7ok4uw	3706	9	determinants	determinant	NNS
cord-001835-0s7ok4uw	3706	10	that	that	WDT
cord-001835-0s7ok4uw	3706	11	could	could	MD
cord-001835-0s7ok4uw	3706	12	account	account	VB
cord-001835-0s7ok4uw	3706	13	for	for	IN
cord-001835-0s7ok4uw	3706	14	these	these	DT
cord-001835-0s7ok4uw	3706	15	features	feature	NNS
cord-001835-0s7ok4uw	3706	16	,	,	,
cord-001835-0s7ok4uw	3706	17	especially	especially	RB
cord-001835-0s7ok4uw	3706	18	for	for	IN
cord-001835-0s7ok4uw	3706	19	the	the	DT
cord-001835-0s7ok4uw	3706	20	difference	difference	NN
cord-001835-0s7ok4uw	3706	21	in	in	IN
cord-001835-0s7ok4uw	3706	22	the	the	DT
cord-001835-0s7ok4uw	3706	23	conformational	conformational	JJ
cord-001835-0s7ok4uw	3706	24	change	change	NN
cord-001835-0s7ok4uw	3706	25	.	.	.
cord-001835-0s7ok4uw	3707	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3707	2	examined	examine	VBD
cord-001835-0s7ok4uw	3707	3	the	the	DT
cord-001835-0s7ok4uw	3707	4	primary	primary	JJ
cord-001835-0s7ok4uw	3707	5	structure	structure	NN
cord-001835-0s7ok4uw	3707	6	from	from	IN
cord-001835-0s7ok4uw	3707	7	two	two	CD
cord-001835-0s7ok4uw	3707	8	EF	EF	NNP
cord-001835-0s7ok4uw	3707	9	-	-	HYPH
cord-001835-0s7ok4uw	3707	10	hand	hand	NN
cord-001835-0s7ok4uw	3707	11	motifs	motif	NNS
cord-001835-0s7ok4uw	3707	12	:	:	:
cord-001835-0s7ok4uw	3707	13	a	a	DT
cord-001835-0s7ok4uw	3707	14	sensor	sensor	NN
cord-001835-0s7ok4uw	3707	15	EF	ef	NN
cord-001835-0s7ok4uw	3707	16	-	-	HYPH
cord-001835-0s7ok4uw	3707	17	hand	hand	NN
cord-001835-0s7ok4uw	3707	18	from	from	IN
cord-001835-0s7ok4uw	3707	19	chicken	chicken	NN
cord-001835-0s7ok4uw	3707	20	troponin	troponin	NNP
cord-001835-0s7ok4uw	3707	21	C	C	NNP
cord-001835-0s7ok4uw	3707	22	(	(	-LRB-
cord-001835-0s7ok4uw	3707	23	SCIII	SCIII	NNP
cord-001835-0s7ok4uw	3707	24	)	)	-RRB-
cord-001835-0s7ok4uw	3707	25	and	and	CC
cord-001835-0s7ok4uw	3707	26	a	a	DT
cord-001835-0s7ok4uw	3707	27	modulator	modulator	NN
cord-001835-0s7ok4uw	3707	28	EF	ef	NN
cord-001835-0s7ok4uw	3707	29	-	-	HYPH
cord-001835-0s7ok4uw	3707	30	hand	hand	NN
cord-001835-0s7ok4uw	3707	31	from	from	IN
cord-001835-0s7ok4uw	3707	32	bovine	bovine	JJ
cord-001835-0s7ok4uw	3707	33	Calbindin	Calbindin	NNP
cord-001835-0s7ok4uw	3707	34	D9k	D9k	NNP
cord-001835-0s7ok4uw	3707	35	(	(	-LRB-
cord-001835-0s7ok4uw	3707	36	ClbN	ClbN	NNP
cord-001835-0s7ok4uw	3707	37	)	)	-RRB-
cord-001835-0s7ok4uw	3707	38	.	.	.
cord-001835-0s7ok4uw	3708	1	The	the	DT
cord-001835-0s7ok4uw	3708	2	main	main	JJ
cord-001835-0s7ok4uw	3708	3	differences	difference	NNS
cord-001835-0s7ok4uw	3708	4	were	be	VBD
cord-001835-0s7ok4uw	3708	5	in	in	IN
cord-001835-0s7ok4uw	3708	6	the	the	DT
cord-001835-0s7ok4uw	3708	7	binding	binding	NN
cord-001835-0s7ok4uw	3708	8	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	3708	9	loop	loop	NN
cord-001835-0s7ok4uw	3708	10	and	and	CC
cord-001835-0s7ok4uw	3708	11	a	a	DT
cord-001835-0s7ok4uw	3708	12	group	group	NN
cord-001835-0s7ok4uw	3708	13	of	of	IN
cord-001835-0s7ok4uw	3708	14	charged	charge	VBN
cord-001835-0s7ok4uw	3708	15	residues	residue	NNS
cord-001835-0s7ok4uw	3708	16	in	in	IN
cord-001835-0s7ok4uw	3708	17	the	the	DT
cord-001835-0s7ok4uw	3708	18	H2	H2	NNP
cord-001835-0s7ok4uw	3708	19	helix	helix	NN
cord-001835-0s7ok4uw	3708	20	of	of	IN
cord-001835-0s7ok4uw	3708	21	the	the	DT
cord-001835-0s7ok4uw	3708	22	modulator	modulator	NN
cord-001835-0s7ok4uw	3708	23	EF	EF	NNP
cord-001835-0s7ok4uw	3708	24	-	-	HYPH
cord-001835-0s7ok4uw	3708	25	hand	hand	NN
cord-001835-0s7ok4uw	3708	26	.	.	.
cord-001835-0s7ok4uw	3709	1	Then	then	RB
cord-001835-0s7ok4uw	3709	2	,	,	,
cord-001835-0s7ok4uw	3709	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3709	4	constructed	construct	VBD
cord-001835-0s7ok4uw	3709	5	chimeric	chimeric	JJ
cord-001835-0s7ok4uw	3709	6	ClbN	ClbN	NNP
cord-001835-0s7ok4uw	3709	7	motifs	motif	NNS
cord-001835-0s7ok4uw	3709	8	containing	contain	VBG
cord-001835-0s7ok4uw	3709	9	the	the	DT
cord-001835-0s7ok4uw	3709	10	loop	loop	NN
cord-001835-0s7ok4uw	3709	11	or	or	CC
cord-001835-0s7ok4uw	3709	12	the	the	DT
cord-001835-0s7ok4uw	3709	13	loop	loop	NN
cord-001835-0s7ok4uw	3709	14	and	and	CC
cord-001835-0s7ok4uw	3709	15	H2	h2	NN
cord-001835-0s7ok4uw	3709	16	from	from	IN
cord-001835-0s7ok4uw	3709	17	SCIII	SCIII	NNP
cord-001835-0s7ok4uw	3709	18	motif	motif	NN
cord-001835-0s7ok4uw	3709	19	(	(	-LRB-
cord-001835-0s7ok4uw	3709	20	H1ClbNSCIII	H1ClbNSCIII	NNP
cord-001835-0s7ok4uw	3709	21	and	and	CC
cord-001835-0s7ok4uw	3709	22	H1H2ClbNSCIII	H1H2ClbNSCIII	NNP
cord-001835-0s7ok4uw	3709	23	)	)	-RRB-
cord-001835-0s7ok4uw	3709	24	.	.	.
cord-001835-0s7ok4uw	3710	1	These	these	DT
cord-001835-0s7ok4uw	3710	2	constructs	construct	NNS
cord-001835-0s7ok4uw	3710	3	were	be	VBD
cord-001835-0s7ok4uw	3710	4	analyzed	analyze	VBN
cord-001835-0s7ok4uw	3710	5	using	use	VBG
cord-001835-0s7ok4uw	3710	6	a	a	DT
cord-001835-0s7ok4uw	3710	7	reporter	reporter	NN
cord-001835-0s7ok4uw	3710	8	system	system	NN
cord-001835-0s7ok4uw	3710	9	that	that	WDT
cord-001835-0s7ok4uw	3710	10	discriminates	discriminate	VBZ
cord-001835-0s7ok4uw	3710	11	EF	ef	NN
cord-001835-0s7ok4uw	3710	12	-	-	HYPH
cord-001835-0s7ok4uw	3710	13	hand	hand	NN
cord-001835-0s7ok4uw	3710	14	-	-	HYPH
cord-001835-0s7ok4uw	3710	15	sensor	sensor	NN
cord-001835-0s7ok4uw	3710	16	motifs	motif	NNS
cord-001835-0s7ok4uw	3710	17	from	from	IN
cord-001835-0s7ok4uw	3710	18	signal	signal	NN
cord-001835-0s7ok4uw	3710	19	-	-	HYPH
cord-001835-0s7ok4uw	3710	20	modulators	modulator	NNS
cord-001835-0s7ok4uw	3710	21	at	at	IN
cord-001835-0s7ok4uw	3710	22	the	the	DT
cord-001835-0s7ok4uw	3710	23	single	single	JJ
cord-001835-0s7ok4uw	3710	24	-	-	HYPH
cord-001835-0s7ok4uw	3710	25	motif	motif	NN
cord-001835-0s7ok4uw	3710	26	level	level	NN
cord-001835-0s7ok4uw	3710	27	.	.	.
cord-001835-0s7ok4uw	3711	1	This	this	DT
cord-001835-0s7ok4uw	3711	2	reporter	reporter	NN
cord-001835-0s7ok4uw	3711	3	is	be	VBZ
cord-001835-0s7ok4uw	3711	4	based	base	VBN
cord-001835-0s7ok4uw	3711	5	on	on	IN
cord-001835-0s7ok4uw	3711	6	the	the	DT
cord-001835-0s7ok4uw	3711	7	fusion	fusion	NN
cord-001835-0s7ok4uw	3711	8	of	of	IN
cord-001835-0s7ok4uw	3711	9	genes	gene	NNS
cord-001835-0s7ok4uw	3711	10	codifying	codify	VBG
cord-001835-0s7ok4uw	3711	11	for	for	IN
cord-001835-0s7ok4uw	3711	12	the	the	DT
cord-001835-0s7ok4uw	3711	13	EF	EF	NNP
cord-001835-0s7ok4uw	3711	14	-	-	HYPH
cord-001835-0s7ok4uw	3711	15	hand	hand	NN
cord-001835-0s7ok4uw	3711	16	and	and	CC
cord-001835-0s7ok4uw	3711	17	the	the	DT
cord-001835-0s7ok4uw	3711	18	prephenate	prephenate	NN
cord-001835-0s7ok4uw	3711	19	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	3711	20	from	from	IN
cord-001835-0s7ok4uw	3711	21	E.	E.	NNP
cord-001835-0s7ok4uw	3711	22	coli	coli	NNS
cord-001835-0s7ok4uw	3711	23	(	(	-LRB-
cord-001835-0s7ok4uw	3711	24	TyrA	TyrA	NNP
cord-001835-0s7ok4uw	3711	25	)	)	-RRB-
cord-001835-0s7ok4uw	3711	26	,	,	,
cord-001835-0s7ok4uw	3711	27	a	a	DT
cord-001835-0s7ok4uw	3711	28	protein	protein	NN
cord-001835-0s7ok4uw	3711	29	which	which	WDT
cord-001835-0s7ok4uw	3711	30	is	be	VBZ
cord-001835-0s7ok4uw	3711	31	active	active	JJ
cord-001835-0s7ok4uw	3711	32	only	only	RB
cord-001835-0s7ok4uw	3711	33	as	as	IN
cord-001835-0s7ok4uw	3711	34	a	a	DT
cord-001835-0s7ok4uw	3711	35	dimer	dimer	NN
cord-001835-0s7ok4uw	3711	36	.	.	.
cord-001835-0s7ok4uw	3712	1	Isolated	isolated	JJ
cord-001835-0s7ok4uw	3712	2	EF	ef	NN
cord-001835-0s7ok4uw	3712	3	-	-	HYPH
cord-001835-0s7ok4uw	3712	4	hand	hand	NN
cord-001835-0s7ok4uw	3712	5	motifs	motif	NNS
cord-001835-0s7ok4uw	3712	6	have	have	VBP
cord-001835-0s7ok4uw	3712	7	the	the	DT
cord-001835-0s7ok4uw	3712	8	ability	ability	NN
cord-001835-0s7ok4uw	3712	9	to	to	IN
cord-001835-0s7ok4uw	3712	10	homo	homo	NN
cord-001835-0s7ok4uw	3712	11	-	-	HYPH
cord-001835-0s7ok4uw	3712	12	dimerize	dimerize	NNP
cord-001835-0s7ok4uw	3712	13	and	and	CC
cord-001835-0s7ok4uw	3712	14	in	in	IN
cord-001835-0s7ok4uw	3712	15	the	the	DT
cord-001835-0s7ok4uw	3712	16	fusion	fusion	NN
cord-001835-0s7ok4uw	3712	17	can	can	MD
cord-001835-0s7ok4uw	3712	18	stabilize	stabilize	VB
cord-001835-0s7ok4uw	3712	19	and	and	CC
cord-001835-0s7ok4uw	3712	20	activate	activate	VB
cord-001835-0s7ok4uw	3712	21	TyrA.	TyrA.	NNP
cord-001835-0s7ok4uw	3713	1	The	the	DT
cord-001835-0s7ok4uw	3713	2	sensor	sensor	NN
cord-001835-0s7ok4uw	3713	3	motif	motif	NN
cord-001835-0s7ok4uw	3713	4	exhibits	exhibit	VBZ
cord-001835-0s7ok4uw	3713	5	a	a	DT
cord-001835-0s7ok4uw	3713	6	conformational	conformational	JJ
cord-001835-0s7ok4uw	3713	7	change	change	NN
cord-001835-0s7ok4uw	3713	8	by	by	IN
cord-001835-0s7ok4uw	3713	9	binding	bind	VBG
cord-001835-0s7ok4uw	3713	10	calcium	calcium	NN
cord-001835-0s7ok4uw	3713	11	and	and	CC
cord-001835-0s7ok4uw	3713	12	in	in	IN
cord-001835-0s7ok4uw	3713	13	doing	do	VBG
cord-001835-0s7ok4uw	3713	14	so	so	RB
cord-001835-0s7ok4uw	3713	15	,	,	,
cord-001835-0s7ok4uw	3713	16	destabilizes	destabilize	VBZ
cord-001835-0s7ok4uw	3713	17	the	the	DT
cord-001835-0s7ok4uw	3713	18	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	3713	19	conformation	conformation	NN
cord-001835-0s7ok4uw	3713	20	of	of	IN
cord-001835-0s7ok4uw	3713	21	TyrA	TyrA	NNP
cord-001835-0s7ok4uw	3713	22	and	and	CC
cord-001835-0s7ok4uw	3713	23	virtually	virtually	RB
cord-001835-0s7ok4uw	3713	24	eliminates	eliminate	VBZ
cord-001835-0s7ok4uw	3713	25	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3713	26	activity	activity	NN
cord-001835-0s7ok4uw	3713	27	.	.	.
cord-001835-0s7ok4uw	3714	1	In	in	IN
cord-001835-0s7ok4uw	3714	2	the	the	DT
cord-001835-0s7ok4uw	3714	3	modulators	modulator	NNS
cord-001835-0s7ok4uw	3714	4	,	,	,
cord-001835-0s7ok4uw	3714	5	on	on	IN
cord-001835-0s7ok4uw	3714	6	the	the	DT
cord-001835-0s7ok4uw	3714	7	other	other	JJ
cord-001835-0s7ok4uw	3714	8	hand	hand	NN
cord-001835-0s7ok4uw	3714	9	,	,	,
cord-001835-0s7ok4uw	3714	10	the	the	DT
cord-001835-0s7ok4uw	3714	11	rather	rather	RB
cord-001835-0s7ok4uw	3714	12	small	small	JJ
cord-001835-0s7ok4uw	3714	13	conformational	conformational	JJ
cord-001835-0s7ok4uw	3714	14	change	change	NN
cord-001835-0s7ok4uw	3714	15	only	only	RB
cord-001835-0s7ok4uw	3714	16	gives	give	VBZ
cord-001835-0s7ok4uw	3714	17	rise	rise	NN
cord-001835-0s7ok4uw	3714	18	to	to	IN
cord-001835-0s7ok4uw	3714	19	a	a	DT
cord-001835-0s7ok4uw	3714	20	decreased	decrease	VBN
cord-001835-0s7ok4uw	3714	21	TyrA	TyrA	NNP
cord-001835-0s7ok4uw	3714	22	activity	activity	NN
cord-001835-0s7ok4uw	3714	23	.	.	.
cord-001835-0s7ok4uw	3715	1	Both	both	DT
cord-001835-0s7ok4uw	3715	2	constructed	construct	VBN
cord-001835-0s7ok4uw	3715	3	chimeric	chimeric	JJ
cord-001835-0s7ok4uw	3715	4	EF	ef	NN
cord-001835-0s7ok4uw	3715	5	-	-	HYPH
cord-001835-0s7ok4uw	3715	6	hand	hand	NN
cord-001835-0s7ok4uw	3715	7	fusions	fusion	NNS
cord-001835-0s7ok4uw	3715	8	showed	show	VBD
cord-001835-0s7ok4uw	3715	9	a	a	DT
cord-001835-0s7ok4uw	3715	10	loss	loss	NN
cord-001835-0s7ok4uw	3715	11	of	of	IN
cord-001835-0s7ok4uw	3715	12	activity	activity	NN
cord-001835-0s7ok4uw	3715	13	upon	upon	IN
cord-001835-0s7ok4uw	3715	14	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	3716	1	binding	bind	VBG
cord-001835-0s7ok4uw	3716	2	,	,	,
cord-001835-0s7ok4uw	3716	3	indicating	indicate	VBG
cord-001835-0s7ok4uw	3716	4	that	that	IN
cord-001835-0s7ok4uw	3716	5	the	the	DT
cord-001835-0s7ok4uw	3716	6	12	12	CD
cord-001835-0s7ok4uw	3716	7	residues	residue	NNS
cord-001835-0s7ok4uw	3716	8	connector	connector	NN
cord-001835-0s7ok4uw	3716	9	of	of	IN
cord-001835-0s7ok4uw	3716	10	the	the	DT
cord-001835-0s7ok4uw	3716	11	sensor	sensor	NN
cord-001835-0s7ok4uw	3716	12	EF	EF	NNP
cord-001835-0s7ok4uw	3716	13	-	-	HYPH
cord-001835-0s7ok4uw	3716	14	hand	hand	NN
cord-001835-0s7ok4uw	3716	15	from	from	IN
cord-001835-0s7ok4uw	3716	16	SCIII	SCIII	NNP
cord-001835-0s7ok4uw	3716	17	is	be	VBZ
cord-001835-0s7ok4uw	3716	18	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	3716	19	to	to	TO
cord-001835-0s7ok4uw	3716	20	confer	confer	VB
cord-001835-0s7ok4uw	3716	21	the	the	DT
cord-001835-0s7ok4uw	3716	22	conformational	conformational	JJ
cord-001835-0s7ok4uw	3716	23	change	change	NN
cord-001835-0s7ok4uw	3716	24	.	.	.
cord-001835-0s7ok4uw	3717	1	In	in	IN
cord-001835-0s7ok4uw	3717	2	addition	addition	NN
cord-001835-0s7ok4uw	3717	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3717	4	used	use	VBD
cord-001835-0s7ok4uw	3717	5	CD	cd	NN
cord-001835-0s7ok4uw	3717	6	and	and	CC
cord-001835-0s7ok4uw	3717	7	extrinsic	extrinsic	JJ
cord-001835-0s7ok4uw	3717	8	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3717	9	spectroscopies	spectroscopy	NNS
cord-001835-0s7ok4uw	3717	10	to	to	TO
cord-001835-0s7ok4uw	3717	11	analyze	analyze	VB
cord-001835-0s7ok4uw	3717	12	any	any	DT
cord-001835-0s7ok4uw	3717	13	conformational	conformational	JJ
cord-001835-0s7ok4uw	3717	14	change	change	NN
cord-001835-0s7ok4uw	3717	15	in	in	IN
cord-001835-0s7ok4uw	3717	16	the	the	DT
cord-001835-0s7ok4uw	3717	17	H1H2ClbNSCIII	H1H2ClbNSCIII	NNP
cord-001835-0s7ok4uw	3717	18	and	and	CC
cord-001835-0s7ok4uw	3717	19	H1ClbNSCIII	H1ClbNSCIII	NNP
cord-001835-0s7ok4uw	3717	20	isolated	isolate	VBN
cord-001835-0s7ok4uw	3717	21	modules	module	NNS
cord-001835-0s7ok4uw	3717	22	,	,	,
cord-001835-0s7ok4uw	3717	23	not	not	RB
cord-001835-0s7ok4uw	3717	24	finding	find	VBG
cord-001835-0s7ok4uw	3717	25	any	any	DT
cord-001835-0s7ok4uw	3717	26	difference	difference	NN
cord-001835-0s7ok4uw	3717	27	between	between	IN
cord-001835-0s7ok4uw	3717	28	the	the	DT
cord-001835-0s7ok4uw	3717	29	Ca21	ca21	NN
cord-001835-0s7ok4uw	3717	30	free	free	JJ
cord-001835-0s7ok4uw	3717	31	and	and	CC
cord-001835-0s7ok4uw	3717	32	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	3718	1	bound	bind	VBN
cord-001835-0s7ok4uw	3718	2	chimeras	chimera	NNS
cord-001835-0s7ok4uw	3718	3	,	,	,
cord-001835-0s7ok4uw	3718	4	suggesting	suggest	VBG
cord-001835-0s7ok4uw	3718	5	that	that	IN
cord-001835-0s7ok4uw	3718	6	the	the	DT
cord-001835-0s7ok4uw	3718	7	change	change	NN
cord-001835-0s7ok4uw	3718	8	in	in	IN
cord-001835-0s7ok4uw	3718	9	activity	activity	NN
cord-001835-0s7ok4uw	3718	10	of	of	IN
cord-001835-0s7ok4uw	3718	11	the	the	DT
cord-001835-0s7ok4uw	3718	12	reporter	reporter	NN
cord-001835-0s7ok4uw	3718	13	protein	protein	NN
cord-001835-0s7ok4uw	3718	14	is	be	VBZ
cord-001835-0s7ok4uw	3718	15	due	due	JJ
cord-001835-0s7ok4uw	3718	16	to	to	IN
cord-001835-0s7ok4uw	3718	17	a	a	DT
cord-001835-0s7ok4uw	3718	18	change	change	NN
cord-001835-0s7ok4uw	3718	19	in	in	IN
cord-001835-0s7ok4uw	3718	20	the	the	DT
cord-001835-0s7ok4uw	3718	21	orientation	orientation	NN
cord-001835-0s7ok4uw	3718	22	of	of	IN
cord-001835-0s7ok4uw	3718	23	the	the	DT
cord-001835-0s7ok4uw	3718	24	helices	helix	NNS
cord-001835-0s7ok4uw	3718	25	in	in	IN
cord-001835-0s7ok4uw	3718	26	the	the	DT
cord-001835-0s7ok4uw	3718	27	EF	EF	NNP
cord-001835-0s7ok4uw	3718	28	-	-	HYPH
cord-001835-0s7ok4uw	3718	29	hands	hand	NNS
cord-001835-0s7ok4uw	3718	30	induced	induce	VBN
cord-001835-0s7ok4uw	3718	31	by	by	IN
cord-001835-0s7ok4uw	3718	32	calcium	calcium	NN
cord-001835-0s7ok4uw	3718	33	.	.	.
cord-001835-0s7ok4uw	3719	1	The	the	DT
cord-001835-0s7ok4uw	3719	2	effect	effect	NN
cord-001835-0s7ok4uw	3719	3	of	of	IN
cord-001835-0s7ok4uw	3719	4	Ca21	Ca21	NNP
cord-001835-0s7ok4uw	3720	1	binding	bind	VBG
cord-001835-0s7ok4uw	3720	2	of	of	IN
cord-001835-0s7ok4uw	3720	3	the	the	DT
cord-001835-0s7ok4uw	3720	4	chimeras	chimera	NNS
cord-001835-0s7ok4uw	3720	5	in	in	IN
cord-001835-0s7ok4uw	3720	6	the	the	DT
cord-001835-0s7ok4uw	3720	7	context	context	NN
cord-001835-0s7ok4uw	3720	8	of	of	IN
cord-001835-0s7ok4uw	3720	9	the	the	DT
cord-001835-0s7ok4uw	3720	10	entire	entire	JJ
cord-001835-0s7ok4uw	3720	11	Calbindin	Calbindin	NNP
cord-001835-0s7ok4uw	3720	12	D9k	d9k	NN
cord-001835-0s7ok4uw	3720	13	protein	protein	NN
cord-001835-0s7ok4uw	3720	14	is	be	VBZ
cord-001835-0s7ok4uw	3720	15	under	under	IN
cord-001835-0s7ok4uw	3720	16	investigation	investigation	NN
cord-001835-0s7ok4uw	3720	17	.	.	.
cord-001835-0s7ok4uw	3720	18	 	 	_SP
cord-001835-0s7ok4uw	3721	1	Mapping	mapping	NN
cord-001835-0s7ok4uw	3721	2	side	side	NN
cord-001835-0s7ok4uw	3721	3	chain	chain	NN
cord-001835-0s7ok4uw	3721	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	3721	5	at	at	IN
cord-001835-0s7ok4uw	3721	6	the	the	DT
cord-001835-0s7ok4uw	3721	7	N	N	NNP
cord-001835-0s7ok4uw	3721	8	-	-	HYPH
cord-001835-0s7ok4uw	3721	9	and	and	CC
cord-001835-0s7ok4uw	3721	10	C	C	NNP
cord-001835-0s7ok4uw	3721	11	-	-	HYPH
cord-001835-0s7ok4uw	3721	12	termini	termini	NNP
cord-001835-0s7ok4uw	3721	13	of	of	IN
cord-001835-0s7ok4uw	3721	14	protein	protein	NN
cord-001835-0s7ok4uw	3721	15	helices	helix	NNS
cord-001835-0s7ok4uw	3721	16	Nicholas	Nicholas	NNP
cord-001835-0s7ok4uw	3721	17	E	E	NNP
cord-001835-0s7ok4uw	3721	18	Newell	Newell	NNP
cord-001835-0s7ok4uw	3721	19	,	,	,
cord-001835-0s7ok4uw	3721	20	Independent	Independent	NNP
cord-001835-0s7ok4uw	3721	21	Researcher	Researcher	NNP
cord-001835-0s7ok4uw	3721	22	Interactions	Interactions	NNP
cord-001835-0s7ok4uw	3721	23	involving	involve	VBG
cord-001835-0s7ok4uw	3721	24	one	one	CD
cord-001835-0s7ok4uw	3721	25	or	or	CC
cord-001835-0s7ok4uw	3721	26	more	more	JJR
cord-001835-0s7ok4uw	3721	27	amino	amino	NN
cord-001835-0s7ok4uw	3721	28	acid	acid	NN
cord-001835-0s7ok4uw	3721	29	side	side	NN
cord-001835-0s7ok4uw	3721	30	chains	chain	NNS
cord-001835-0s7ok4uw	3721	31	near	near	IN
cord-001835-0s7ok4uw	3721	32	the	the	DT
cord-001835-0s7ok4uw	3721	33	ends	end	NNS
cord-001835-0s7ok4uw	3721	34	of	of	IN
cord-001835-0s7ok4uw	3721	35	protein	protein	NN
cord-001835-0s7ok4uw	3721	36	helices	helix	NNS
cord-001835-0s7ok4uw	3721	37	stabilize	stabilize	VBP
cord-001835-0s7ok4uw	3721	38	helix	helix	NN
cord-001835-0s7ok4uw	3721	39	termini	terminus	NNS
cord-001835-0s7ok4uw	3721	40	and	and	CC
cord-001835-0s7ok4uw	3721	41	shape	shape	VB
cord-001835-0s7ok4uw	3721	42	the	the	DT
cord-001835-0s7ok4uw	3721	43	geometry	geometry	NN
cord-001835-0s7ok4uw	3721	44	of	of	IN
cord-001835-0s7ok4uw	3721	45	the	the	DT
cord-001835-0s7ok4uw	3721	46	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	3721	47	loops	loop	NNS
cord-001835-0s7ok4uw	3721	48	,	,	,
cord-001835-0s7ok4uw	3721	49	contributing	contribute	VBG
cord-001835-0s7ok4uw	3721	50	to	to	IN
cord-001835-0s7ok4uw	3721	51	supersecondary	supersecondary	JJ
cord-001835-0s7ok4uw	3721	52	structure	structure	NN
cord-001835-0s7ok4uw	3721	53	.	.	.
cord-001835-0s7ok4uw	3722	1	Side	side	NN
cord-001835-0s7ok4uw	3722	2	chain	chain	NN
cord-001835-0s7ok4uw	3722	3	structures	structure	NNS
cord-001835-0s7ok4uw	3722	4	that	that	WDT
cord-001835-0s7ok4uw	3722	5	have	have	VBP
cord-001835-0s7ok4uw	3722	6	been	be	VBN
cord-001835-0s7ok4uw	3722	7	identified	identify	VBN
cord-001835-0s7ok4uw	3722	8	at	at	IN
cord-001835-0s7ok4uw	3722	9	the	the	DT
cord-001835-0s7ok4uw	3722	10	helical	helical	JJ
cord-001835-0s7ok4uw	3722	11	N	n	CD
cord-001835-0s7ok4uw	3722	12	-	-	HYPH
cord-001835-0s7ok4uw	3722	13	terminus	terminus	NN
cord-001835-0s7ok4uw	3722	14	include	include	VBP
cord-001835-0s7ok4uw	3722	15	the	the	DT
cord-001835-0s7ok4uw	3722	16	Asx	Asx	NNP
cord-001835-0s7ok4uw	3722	17	/	/	SYM
cord-001835-0s7ok4uw	3722	18	ST	ST	NNP
cord-001835-0s7ok4uw	3722	19	N	N	NNP
cord-001835-0s7ok4uw	3722	20	-	-	HYPH
cord-001835-0s7ok4uw	3722	21	caps	cap	NNS
cord-001835-0s7ok4uw	3722	22	,	,	,
cord-001835-0s7ok4uw	3722	23	the	the	DT
cord-001835-0s7ok4uw	3722	24	capping	cap	VBG
cord-001835-0s7ok4uw	3722	25	box	box	NN
cord-001835-0s7ok4uw	3722	26	,	,	,
cord-001835-0s7ok4uw	3722	27	and	and	CC
cord-001835-0s7ok4uw	3722	28	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3722	29	and	and	CC
cord-001835-0s7ok4uw	3722	30	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	3722	31	interactions	interaction	NNS
cord-001835-0s7ok4uw	3722	32	.	.	.
cord-001835-0s7ok4uw	3723	1	At	at	IN
cord-001835-0s7ok4uw	3723	2	the	the	DT
cord-001835-0s7ok4uw	3723	3	Cterminus	Cterminus	NNP
cord-001835-0s7ok4uw	3723	4	,	,	,
cord-001835-0s7ok4uw	3723	5	capping	cap	VBG
cord-001835-0s7ok4uw	3723	6	is	be	VBZ
cord-001835-0s7ok4uw	3723	7	often	often	RB
cord-001835-0s7ok4uw	3723	8	achieved	achieve	VBN
cord-001835-0s7ok4uw	3723	9	with	with	IN
cord-001835-0s7ok4uw	3723	10	main	main	JJ
cord-001835-0s7ok4uw	3723	11	-	-	HYPH
cord-001835-0s7ok4uw	3723	12	chain	chain	NN
cord-001835-0s7ok4uw	3723	13	polar	polar	JJ
cord-001835-0s7ok4uw	3723	14	groups	group	NNS
cord-001835-0s7ok4uw	3723	15	,	,	,
cord-001835-0s7ok4uw	3723	16	(	(	-LRB-
cord-001835-0s7ok4uw	3723	17	e.g.	e.g.	RB
cord-001835-0s7ok4uw	3723	18	the	the	DT
cord-001835-0s7ok4uw	3723	19	Schellman	Schellman	NNP
cord-001835-0s7ok4uw	3723	20	loop	loop	NN
cord-001835-0s7ok4uw	3723	21	)	)	-RRB-
cord-001835-0s7ok4uw	3723	22	,	,	,
cord-001835-0s7ok4uw	3723	23	but	but	CC
cord-001835-0s7ok4uw	3723	24	here	here	RB
cord-001835-0s7ok4uw	3723	25	also	also	RB
cord-001835-0s7ok4uw	3723	26	particular	particular	JJ
cord-001835-0s7ok4uw	3723	27	side	side	NN
cord-001835-0s7ok4uw	3723	28	chain	chain	NN
cord-001835-0s7ok4uw	3723	29	motifs	motif	NNS
cord-001835-0s7ok4uw	3723	30	clearly	clearly	RB
cord-001835-0s7ok4uw	3723	31	favor	favor	VBP
cord-001835-0s7ok4uw	3723	32	specific	specific	JJ
cord-001835-0s7ok4uw	3723	33	loop	loop	NN
cord-001835-0s7ok4uw	3723	34	geometries	geometry	NNS
cord-001835-0s7ok4uw	3723	35	.	.	.
cord-001835-0s7ok4uw	3724	1	Key	key	JJ
cord-001835-0s7ok4uw	3724	2	questions	question	NNS
cord-001835-0s7ok4uw	3724	3	that	that	WDT
cord-001835-0s7ok4uw	3724	4	remain	remain	VBP
cord-001835-0s7ok4uw	3724	5	concerning	concern	VBG
cord-001835-0s7ok4uw	3724	6	side	side	NN
cord-001835-0s7ok4uw	3724	7	chain	chain	NN
cord-001835-0s7ok4uw	3724	8	interactions	interaction	NNS
cord-001835-0s7ok4uw	3724	9	at	at	IN
cord-001835-0s7ok4uw	3724	10	helix	helix	NN
cord-001835-0s7ok4uw	3724	11	termini	terminus	NNS
cord-001835-0s7ok4uw	3724	12	include	include	VBP
cord-001835-0s7ok4uw	3724	13	:	:	:
cord-001835-0s7ok4uw	3724	14	1	1	LS
cord-001835-0s7ok4uw	3724	15	)	)	-RRB-
cord-001835-0s7ok4uw	3725	1	To	to	TO
cord-001835-0s7ok4uw	3725	2	what	what	WDT
cord-001835-0s7ok4uw	3725	3	extent	extent	NN
cord-001835-0s7ok4uw	3725	4	are	be	VBP
cord-001835-0s7ok4uw	3725	5	helix	helix	NN
cord-001835-0s7ok4uw	3725	6	-	-	HYPH
cord-001835-0s7ok4uw	3725	7	terminal	terminal	NN
cord-001835-0s7ok4uw	3725	8	motifs	motif	NNS
cord-001835-0s7ok4uw	3725	9	that	that	WDT
cord-001835-0s7ok4uw	3725	10	include	include	VBP
cord-001835-0s7ok4uw	3725	11	multiple	multiple	JJ
cord-001835-0s7ok4uw	3725	12	amino	amino	NN
cord-001835-0s7ok4uw	3725	13	acids	acid	NNS
cord-001835-0s7ok4uw	3725	14	likely	likely	JJ
cord-001835-0s7ok4uw	3725	15	to	to	TO
cord-001835-0s7ok4uw	3725	16	represent	represent	VB
cord-001835-0s7ok4uw	3725	17	genuine	genuine	JJ
cord-001835-0s7ok4uw	3725	18	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	3725	19	interactions	interaction	NNS
cord-001835-0s7ok4uw	3725	20	between	between	IN
cord-001835-0s7ok4uw	3725	21	side	side	NN
cord-001835-0s7ok4uw	3725	22	chains	chain	NNS
cord-001835-0s7ok4uw	3725	23	,	,	,
cord-001835-0s7ok4uw	3725	24	rather	rather	RB
cord-001835-0s7ok4uw	3725	25	than	than	IN
cord-001835-0s7ok4uw	3725	26	chance	chance	VB
cord-001835-0s7ok4uw	3725	27	alignments	alignment	NNS
cord-001835-0s7ok4uw	3725	28	?	?	.
cord-001835-0s7ok4uw	3726	1	2	2	LS
cord-001835-0s7ok4uw	3726	2	)	)	-RRB-
cord-001835-0s7ok4uw	3727	1	Which	which	WDT
cord-001835-0s7ok4uw	3727	2	particular	particular	JJ
cord-001835-0s7ok4uw	3727	3	helix	helix	NN
cord-001835-0s7ok4uw	3727	4	-	-	HYPH
cord-001835-0s7ok4uw	3727	5	terminal	terminal	NN
cord-001835-0s7ok4uw	3727	6	loop	loop	NN
cord-001835-0s7ok4uw	3727	7	geometries	geometry	NNS
cord-001835-0s7ok4uw	3727	8	are	be	VBP
cord-001835-0s7ok4uw	3727	9	favored	favor	VBN
cord-001835-0s7ok4uw	3727	10	by	by	IN
cord-001835-0s7ok4uw	3727	11	each	each	DT
cord-001835-0s7ok4uw	3727	12	side	side	NN
cord-001835-0s7ok4uw	3727	13	chain	chain	NN
cord-001835-0s7ok4uw	3727	14	interaction	interaction	NN
cord-001835-0s7ok4uw	3727	15	?	?	.
cord-001835-0s7ok4uw	3728	1	3	3	LS
cord-001835-0s7ok4uw	3728	2	)	)	-RRB-
cord-001835-0s7ok4uw	3728	3	Can	Can	MD
cord-001835-0s7ok4uw	3728	4	an	an	DT
cord-001835-0s7ok4uw	3728	5	exhaustive	exhaustive	JJ
cord-001835-0s7ok4uw	3728	6	statistical	statistical	JJ
cord-001835-0s7ok4uw	3728	7	scan	scan	NN
cord-001835-0s7ok4uw	3728	8	of	of	IN
cord-001835-0s7ok4uw	3728	9	a	a	DT
cord-001835-0s7ok4uw	3728	10	large	large	JJ
cord-001835-0s7ok4uw	3728	11	,	,	,
cord-001835-0s7ok4uw	3728	12	recent	recent	JJ
cord-001835-0s7ok4uw	3728	13	dataset	dataset	NN
cord-001835-0s7ok4uw	3728	14	identify	identify	VBP
cord-001835-0s7ok4uw	3728	15	new	new	JJ
cord-001835-0s7ok4uw	3728	16	side	side	NN
cord-001835-0s7ok4uw	3728	17	chain	chain	NN
cord-001835-0s7ok4uw	3728	18	interactions	interaction	NNS
cord-001835-0s7ok4uw	3728	19	at	at	IN
cord-001835-0s7ok4uw	3728	20	helix	helix	NN
cord-001835-0s7ok4uw	3728	21	termini	terminus	NNS
cord-001835-0s7ok4uw	3728	22	?	?	.
cord-001835-0s7ok4uw	3729	1	In	in	IN
cord-001835-0s7ok4uw	3729	2	this	this	DT
cord-001835-0s7ok4uw	3729	3	work	work	NN
cord-001835-0s7ok4uw	3729	4	,	,	,
cord-001835-0s7ok4uw	3729	5	three	three	CD
cord-001835-0s7ok4uw	3729	6	analytical	analytical	JJ
cord-001835-0s7ok4uw	3729	7	tools	tool	NNS
cord-001835-0s7ok4uw	3729	8	are	be	VBP
cord-001835-0s7ok4uw	3729	9	applied	apply	VBN
cord-001835-0s7ok4uw	3729	10	to	to	TO
cord-001835-0s7ok4uw	3729	11	answer	answer	VB
cord-001835-0s7ok4uw	3729	12	the	the	DT
cord-001835-0s7ok4uw	3729	13	above	above	JJ
cord-001835-0s7ok4uw	3729	14	questions	question	NNS
cord-001835-0s7ok4uw	3729	15	for	for	IN
cord-001835-0s7ok4uw	3729	16	both	both	CC
cord-001835-0s7ok4uw	3729	17	N	N	NNP
cord-001835-0s7ok4uw	3729	18	-	-	HYPH
cord-001835-0s7ok4uw	3729	19	and	and	CC
cord-001835-0s7ok4uw	3729	20	C	C	NNP
cord-001835-0s7ok4uw	3729	21	-	-	HYPH
cord-001835-0s7ok4uw	3729	22	termini	termini	NNP
cord-001835-0s7ok4uw	3729	23	.	.	.
cord-001835-0s7ok4uw	3730	1	First	first	RB
cord-001835-0s7ok4uw	3730	2	,	,	,
cord-001835-0s7ok4uw	3730	3	a	a	DT
cord-001835-0s7ok4uw	3730	4	new	new	JJ
cord-001835-0s7ok4uw	3730	5	perturbative	perturbative	JJ
cord-001835-0s7ok4uw	3730	6	least	least	JJS
cord-001835-0s7ok4uw	3730	7	-	-	HYPH
cord-001835-0s7ok4uw	3730	8	squares	square	NNS
cord-001835-0s7ok4uw	3730	9	3D	3d	JJ
cord-001835-0s7ok4uw	3730	10	clustering	clustering	NN
cord-001835-0s7ok4uw	3730	11	algorithm	algorithm	NN
cord-001835-0s7ok4uw	3730	12	is	be	VBZ
cord-001835-0s7ok4uw	3730	13	applied	apply	VBN
cord-001835-0s7ok4uw	3730	14	to	to	TO
cord-001835-0s7ok4uw	3730	15	partition	partition	VB
cord-001835-0s7ok4uw	3730	16	the	the	DT
cord-001835-0s7ok4uw	3730	17	helix	helix	NN
cord-001835-0s7ok4uw	3730	18	terminal	terminal	NN
cord-001835-0s7ok4uw	3730	19	structures	structure	NNS
cord-001835-0s7ok4uw	3730	20	in	in	IN
cord-001835-0s7ok4uw	3730	21	a	a	DT
cord-001835-0s7ok4uw	3730	22	large	large	JJ
cord-001835-0s7ok4uw	3730	23	(	(	-LRB-
cord-001835-0s7ok4uw	3730	24	25,000	25,000	CD
cord-001835-0s7ok4uw	3730	25	example	example	NN
cord-001835-0s7ok4uw	3730	26	)	)	-RRB-
cord-001835-0s7ok4uw	3730	27	,	,	,
cord-001835-0s7ok4uw	3730	28	low	low	JJ
cord-001835-0s7ok4uw	3730	29	-	-	HYPH
cord-001835-0s7ok4uw	3730	30	redundancy	redundancy	NN
cord-001835-0s7ok4uw	3730	31	PDB	PDB	NNP
cord-001835-0s7ok4uw	3730	32	dataset	dataset	NN
cord-001835-0s7ok4uw	3730	33	by	by	IN
cord-001835-0s7ok4uw	3730	34	loop	loop	NN
cord-001835-0s7ok4uw	3730	35	backbone	backbone	NN
cord-001835-0s7ok4uw	3730	36	geometry	geometry	NN
cord-001835-0s7ok4uw	3730	37	.	.	.
cord-001835-0s7ok4uw	3731	1	The	the	DT
cord-001835-0s7ok4uw	3731	2	clustering	clustering	NN
cord-001835-0s7ok4uw	3731	3	algorithm	algorithm	NN
cord-001835-0s7ok4uw	3731	4	also	also	RB
cord-001835-0s7ok4uw	3731	5	generates	generate	VBZ
cord-001835-0s7ok4uw	3731	6	a	a	DT
cord-001835-0s7ok4uw	3731	7	set	set	NN
cord-001835-0s7ok4uw	3731	8	of	of	IN
cord-001835-0s7ok4uw	3731	9	structural	structural	JJ
cord-001835-0s7ok4uw	3731	10	exemplars	exemplar	NNS
cord-001835-0s7ok4uw	3731	11	,	,	,
cord-001835-0s7ok4uw	3731	12	one	one	CD
cord-001835-0s7ok4uw	3731	13	for	for	IN
cord-001835-0s7ok4uw	3731	14	each	each	DT
cord-001835-0s7ok4uw	3731	15	cluster	cluster	NN
cord-001835-0s7ok4uw	3731	16	,	,	,
cord-001835-0s7ok4uw	3731	17	that	that	WDT
cord-001835-0s7ok4uw	3731	18	is	be	VBZ
cord-001835-0s7ok4uw	3731	19	used	use	VBN
cord-001835-0s7ok4uw	3731	20	to	to	TO
cord-001835-0s7ok4uw	3731	21	represent	represent	VB
cord-001835-0s7ok4uw	3731	22	the	the	DT
cord-001835-0s7ok4uw	3731	23	most	most	RBS
cord-001835-0s7ok4uw	3731	24	important	important	JJ
cord-001835-0s7ok4uw	3731	25	loop	loop	NN
cord-001835-0s7ok4uw	3731	26	geometries	geometry	NNS
cord-001835-0s7ok4uw	3731	27	at	at	IN
cord-001835-0s7ok4uw	3731	28	each	each	DT
cord-001835-0s7ok4uw	3731	29	terminus	terminus	NN
cord-001835-0s7ok4uw	3731	30	.	.	.
cord-001835-0s7ok4uw	3732	1	Next	next	RB
cord-001835-0s7ok4uw	3732	2	,	,	,
cord-001835-0s7ok4uw	3732	3	Cascade	Cascade	NNP
cord-001835-0s7ok4uw	3732	4	Detection	Detection	NNP
cord-001835-0s7ok4uw	3732	5	(	(	-LRB-
cord-001835-0s7ok4uw	3732	6	Newell	Newell	NNP
cord-001835-0s7ok4uw	3732	7	,	,	,
cord-001835-0s7ok4uw	3732	8	Bioinformatics	Bioinformatics	NNP
cord-001835-0s7ok4uw	3732	9	,	,	,
cord-001835-0s7ok4uw	3732	10	2011	2011	CD
cord-001835-0s7ok4uw	3732	11	)	)	-RRB-
cord-001835-0s7ok4uw	3732	12	,	,	,
cord-001835-0s7ok4uw	3732	13	an	an	DT
cord-001835-0s7ok4uw	3732	14	algorithm	algorithm	NN
cord-001835-0s7ok4uw	3732	15	that	that	WDT
cord-001835-0s7ok4uw	3732	16	detects	detect	VBZ
cord-001835-0s7ok4uw	3732	17	multi	multi	JJ
cord-001835-0s7ok4uw	3732	18	-	-	JJ
cord-001835-0s7ok4uw	3732	19	amino	amino	JJ
cord-001835-0s7ok4uw	3732	20	acid	acid	NN
cord-001835-0s7ok4uw	3732	21	cooperativities	cooperativitie	NNS
cord-001835-0s7ok4uw	3732	22	by	by	IN
cord-001835-0s7ok4uw	3732	23	identifying	identify	VBG
cord-001835-0s7ok4uw	3732	24	overrepresented	overrepresented	JJ
cord-001835-0s7ok4uw	3732	25	sequence	sequence	NN
cord-001835-0s7ok4uw	3732	26	motifs	motif	NNS
cord-001835-0s7ok4uw	3732	27	,	,	,
cord-001835-0s7ok4uw	3732	28	is	be	VBZ
cord-001835-0s7ok4uw	3732	29	applied	apply	VBN
cord-001835-0s7ok4uw	3732	30	to	to	IN
cord-001835-0s7ok4uw	3732	31	each	each	DT
cord-001835-0s7ok4uw	3732	32	cluster	cluster	NN
cord-001835-0s7ok4uw	3732	33	separately	separately	RB
cord-001835-0s7ok4uw	3732	34	to	to	TO
cord-001835-0s7ok4uw	3732	35	determine	determine	VB
cord-001835-0s7ok4uw	3732	36	which	which	WDT
cord-001835-0s7ok4uw	3732	37	motifs	motif	NNS
cord-001835-0s7ok4uw	3732	38	are	be	VBP
cord-001835-0s7ok4uw	3732	39	most	most	RBS
cord-001835-0s7ok4uw	3732	40	important	important	JJ
cord-001835-0s7ok4uw	3732	41	in	in	IN
cord-001835-0s7ok4uw	3732	42	each	each	DT
cord-001835-0s7ok4uw	3732	43	loop	loop	NN
cord-001835-0s7ok4uw	3732	44	geometry	geometry	NN
cord-001835-0s7ok4uw	3732	45	.	.	.
cord-001835-0s7ok4uw	3733	1	Finally	finally	RB
cord-001835-0s7ok4uw	3733	2	,	,	,
cord-001835-0s7ok4uw	3733	3	the	the	DT
cord-001835-0s7ok4uw	3733	4	results	result	NNS
cord-001835-0s7ok4uw	3733	5	for	for	IN
cord-001835-0s7ok4uw	3733	6	each	each	DT
cord-001835-0s7ok4uw	3733	7	motif	motif	NN
cord-001835-0s7ok4uw	3733	8	are	be	VBP
cord-001835-0s7ok4uw	3733	9	displayed	display	VBN
cord-001835-0s7ok4uw	3733	10	in	in	IN
cord-001835-0s7ok4uw	3733	11	a	a	DT
cord-001835-0s7ok4uw	3733	12	CapMap	CapMap	NNP
cord-001835-0s7ok4uw	3733	13	,	,	,
cord-001835-0s7ok4uw	3733	14	a	a	DT
cord-001835-0s7ok4uw	3733	15	3D	3d	JJ
cord-001835-0s7ok4uw	3733	16	conformational	conformational	JJ
cord-001835-0s7ok4uw	3733	17	heatmap	heatmap	NN
cord-001835-0s7ok4uw	3733	18	that	that	WDT
cord-001835-0s7ok4uw	3733	19	depicts	depict	VBZ
cord-001835-0s7ok4uw	3733	20	the	the	DT
cord-001835-0s7ok4uw	3733	21	distribution	distribution	NN
cord-001835-0s7ok4uw	3733	22	of	of	IN
cord-001835-0s7ok4uw	3733	23	motif	motif	NN
cord-001835-0s7ok4uw	3733	24	abundance	abundance	NN
cord-001835-0s7ok4uw	3733	25	and	and	CC
cord-001835-0s7ok4uw	3733	26	overrepresentation	overrepresentation	NN
cord-001835-0s7ok4uw	3733	27	across	across	IN
cord-001835-0s7ok4uw	3733	28	all	all	DT
cord-001835-0s7ok4uw	3733	29	loop	loop	NN
cord-001835-0s7ok4uw	3733	30	geometries	geometry	NNS
cord-001835-0s7ok4uw	3733	31	by	by	IN
cord-001835-0s7ok4uw	3733	32	projecting	project	VBG
cord-001835-0s7ok4uw	3733	33	these	these	DT
cord-001835-0s7ok4uw	3733	34	quantities	quantity	NNS
cord-001835-0s7ok4uw	3733	35	onto	onto	IN
cord-001835-0s7ok4uw	3733	36	the	the	DT
cord-001835-0s7ok4uw	3733	37	structural	structural	JJ
cord-001835-0s7ok4uw	3733	38	exemplars	exemplar	NNS
cord-001835-0s7ok4uw	3733	39	generated	generate	VBN
cord-001835-0s7ok4uw	3733	40	by	by	IN
cord-001835-0s7ok4uw	3733	41	clustering	cluster	VBG
cord-001835-0s7ok4uw	3733	42	.	.	.
cord-001835-0s7ok4uw	3734	1	The	the	DT
cord-001835-0s7ok4uw	3734	2	CapMap	CapMap	NNP
cord-001835-0s7ok4uw	3734	3	reveals	reveal	VBZ
cord-001835-0s7ok4uw	3734	4	the	the	DT
cord-001835-0s7ok4uw	3734	5	loop	loop	NN
cord-001835-0s7ok4uw	3734	6	conformations	conformation	NNS
cord-001835-0s7ok4uw	3734	7	most	most	RBS
cord-001835-0s7ok4uw	3734	8	favored	favor	VBN
cord-001835-0s7ok4uw	3734	9	by	by	IN
cord-001835-0s7ok4uw	3734	10	a	a	DT
cord-001835-0s7ok4uw	3734	11	motif	motif	NN
cord-001835-0s7ok4uw	3734	12	.	.	.
cord-001835-0s7ok4uw	3735	1	Actual	actual	JJ
cord-001835-0s7ok4uw	3735	2	structures	structure	NNS
cord-001835-0s7ok4uw	3735	3	from	from	IN
cord-001835-0s7ok4uw	3735	4	the	the	DT
cord-001835-0s7ok4uw	3735	5	clusters	cluster	NNS
cord-001835-0s7ok4uw	3735	6	corresponding	correspond	VBG
cord-001835-0s7ok4uw	3735	7	to	to	IN
cord-001835-0s7ok4uw	3735	8	these	these	DT
cord-001835-0s7ok4uw	3735	9	favored	favor	VBN
cord-001835-0s7ok4uw	3735	10	conformations	conformation	NNS
cord-001835-0s7ok4uw	3735	11	are	be	VBP
cord-001835-0s7ok4uw	3735	12	then	then	RB
cord-001835-0s7ok4uw	3735	13	examined	examine	VBN
cord-001835-0s7ok4uw	3735	14	in	in	IN
cord-001835-0s7ok4uw	3735	15	a	a	DT
cord-001835-0s7ok4uw	3735	16	structure	structure	NN
cord-001835-0s7ok4uw	3735	17	browser	browser	NN
cord-001835-0s7ok4uw	3735	18	to	to	TO
cord-001835-0s7ok4uw	3735	19	characterize	characterize	VB
cord-001835-0s7ok4uw	3735	20	the	the	DT
cord-001835-0s7ok4uw	3735	21	side	side	NN
cord-001835-0s7ok4uw	3735	22	chain	chain	NN
cord-001835-0s7ok4uw	3735	23	interaction	interaction	NN
cord-001835-0s7ok4uw	3735	24	associated	associate	VBN
cord-001835-0s7ok4uw	3735	25	with	with	IN
cord-001835-0s7ok4uw	3735	26	the	the	DT
cord-001835-0s7ok4uw	3735	27	motif	motif	NN
cord-001835-0s7ok4uw	3735	28	.	.	.
cord-001835-0s7ok4uw	3736	1	This	this	DT
cord-001835-0s7ok4uw	3736	2	work	work	NN
cord-001835-0s7ok4uw	3736	3	identifies	identify	VBZ
cord-001835-0s7ok4uw	3736	4	a	a	DT
cord-001835-0s7ok4uw	3736	5	'	'	``
cord-001835-0s7ok4uw	3736	6	toolkit	toolkit	NN
cord-001835-0s7ok4uw	3736	7	'	'	''
cord-001835-0s7ok4uw	3736	8	of	of	IN
cord-001835-0s7ok4uw	3736	9	side	side	NN
cord-001835-0s7ok4uw	3736	10	chain	chain	NN
cord-001835-0s7ok4uw	3736	11	motifs	motif	NNS
cord-001835-0s7ok4uw	3736	12	which	which	WDT
cord-001835-0s7ok4uw	3736	13	are	be	VBP
cord-001835-0s7ok4uw	3736	14	good	good	JJ
cord-001835-0s7ok4uw	3736	15	candidates	candidate	NNS
cord-001835-0s7ok4uw	3736	16	for	for	IN
cord-001835-0s7ok4uw	3736	17	use	use	NN
cord-001835-0s7ok4uw	3736	18	in	in	IN
cord-001835-0s7ok4uw	3736	19	the	the	DT
cord-001835-0s7ok4uw	3736	20	design	design	NN
cord-001835-0s7ok4uw	3736	21	of	of	IN
cord-001835-0s7ok4uw	3736	22	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3736	23	helix	helix	JJ
cord-001835-0s7ok4uw	3736	24	-	-	HYPH
cord-001835-0s7ok4uw	3736	25	terminal	terminal	NN
cord-001835-0s7ok4uw	3736	26	loops	loop	NNS
cord-001835-0s7ok4uw	3736	27	with	with	IN
cord-001835-0s7ok4uw	3736	28	specific	specific	JJ
cord-001835-0s7ok4uw	3736	29	desired	desire	VBN
cord-001835-0s7ok4uw	3736	30	geometries	geometry	NNS
cord-001835-0s7ok4uw	3736	31	,	,	,
cord-001835-0s7ok4uw	3736	32	because	because	IN
cord-001835-0s7ok4uw	3736	33	they	-PRON-	PRP
cord-001835-0s7ok4uw	3736	34	are	be	VBP
cord-001835-0s7ok4uw	3736	35	used	use	VBN
cord-001835-0s7ok4uw	3736	36	in	in	IN
cord-001835-0s7ok4uw	3736	37	nature	nature	NN
cord-001835-0s7ok4uw	3736	38	to	to	TO
cord-001835-0s7ok4uw	3736	39	support	support	VB
cord-001835-0s7ok4uw	3736	40	these	these	DT
cord-001835-0s7ok4uw	3736	41	geometries	geometry	NNS
cord-001835-0s7ok4uw	3736	42	.	.	.
cord-001835-0s7ok4uw	3737	1	Highlights	highlight	NNS
cord-001835-0s7ok4uw	3737	2	of	of	IN
cord-001835-0s7ok4uw	3737	3	the	the	DT
cord-001835-0s7ok4uw	3737	4	analysis	analysis	NN
cord-001835-0s7ok4uw	3737	5	include	include	VBP
cord-001835-0s7ok4uw	3737	6	determinations	determination	NNS
cord-001835-0s7ok4uw	3737	7	of	of	IN
cord-001835-0s7ok4uw	3737	8	the	the	DT
cord-001835-0s7ok4uw	3737	9	favored	favor	VBN
cord-001835-0s7ok4uw	3737	10	loop	loop	NN
cord-001835-0s7ok4uw	3737	11	geometries	geometry	NNS
cord-001835-0s7ok4uw	3737	12	for	for	IN
cord-001835-0s7ok4uw	3737	13	the	the	DT
cord-001835-0s7ok4uw	3737	14	Asx	Asx	NNP
cord-001835-0s7ok4uw	3737	15	/	/	SYM
cord-001835-0s7ok4uw	3737	16	ST	ST	NNP
cord-001835-0s7ok4uw	3737	17	motifs	motif	NNS
cord-001835-0s7ok4uw	3737	18	,	,	,
cord-001835-0s7ok4uw	3737	19	capping	cap	VBG
cord-001835-0s7ok4uw	3737	20	boxes	box	NNS
cord-001835-0s7ok4uw	3737	21	,	,	,
cord-001835-0s7ok4uw	3737	22	big	big	JJ
cord-001835-0s7ok4uw	3737	23	boxes	box	NNS
cord-001835-0s7ok4uw	3737	24	,	,	,
cord-001835-0s7ok4uw	3737	25	and	and	CC
cord-001835-0s7ok4uw	3737	26	other	other	JJ
cord-001835-0s7ok4uw	3737	27	previously	previously	RB
cord-001835-0s7ok4uw	3737	28	known	know	VBN
cord-001835-0s7ok4uw	3737	29	and	and	CC
cord-001835-0s7ok4uw	3737	30	unknown	unknown	JJ
cord-001835-0s7ok4uw	3737	31	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3737	32	,	,	,
cord-001835-0s7ok4uw	3737	33	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	3737	34	,	,	,
cord-001835-0s7ok4uw	3737	35	H	h	NN
cord-001835-0s7ok4uw	3737	36	-	-	HYPH
cord-001835-0s7ok4uw	3737	37	bond	bond	NN
cord-001835-0s7ok4uw	3737	38	,	,	,
cord-001835-0s7ok4uw	3737	39	and	and	CC
cord-001835-0s7ok4uw	3737	40	pi	pi	NN
cord-001835-0s7ok4uw	3737	41	-	-	HYPH
cord-001835-0s7ok4uw	3737	42	stacking	stack	VBG
cord-001835-0s7ok4uw	3737	43	interactions	interaction	NNS
cord-001835-0s7ok4uw	3737	44	.	.	.
cord-001835-0s7ok4uw	3738	1	A	a	DT
cord-001835-0s7ok4uw	3738	2	goal	goal	NN
cord-001835-0s7ok4uw	3738	3	of	of	IN
cord-001835-0s7ok4uw	3738	4	future	future	JJ
cord-001835-0s7ok4uw	3738	5	work	work	NN
cord-001835-0s7ok4uw	3738	6	is	be	VBZ
cord-001835-0s7ok4uw	3738	7	to	to	TO
cord-001835-0s7ok4uw	3738	8	make	make	VB
cord-001835-0s7ok4uw	3738	9	these	these	DT
cord-001835-0s7ok4uw	3738	10	results	result	NNS
cord-001835-0s7ok4uw	3738	11	available	available	JJ
cord-001835-0s7ok4uw	3738	12	in	in	IN
cord-001835-0s7ok4uw	3738	13	a	a	DT
cord-001835-0s7ok4uw	3738	14	structurally	structurally	RB
cord-001835-0s7ok4uw	3738	15	-	-	HYPH
cord-001835-0s7ok4uw	3738	16	addressable	addressable	JJ
cord-001835-0s7ok4uw	3738	17	database	database	NN
cord-001835-0s7ok4uw	3738	18	that	that	WDT
cord-001835-0s7ok4uw	3738	19	would	would	MD
cord-001835-0s7ok4uw	3738	20	enable	enable	VB
cord-001835-0s7ok4uw	3738	21	researchers	researcher	NNS
cord-001835-0s7ok4uw	3738	22	to	to	TO
cord-001835-0s7ok4uw	3738	23	immediately	immediately	RB
cord-001835-0s7ok4uw	3738	24	retrieve	retrieve	VB
cord-001835-0s7ok4uw	3738	25	the	the	DT
cord-001835-0s7ok4uw	3738	26	side	side	NN
cord-001835-0s7ok4uw	3738	27	chain	chain	NN
cord-001835-0s7ok4uw	3738	28	interactions	interaction	NNS
cord-001835-0s7ok4uw	3738	29	most	most	RBS
cord-001835-0s7ok4uw	3738	30	compatible	compatible	JJ
cord-001835-0s7ok4uw	3738	31	with	with	IN
cord-001835-0s7ok4uw	3738	32	a	a	DT
cord-001835-0s7ok4uw	3738	33	desired	desire	VBN
cord-001835-0s7ok4uw	3738	34	loop	loop	NN
cord-001835-0s7ok4uw	3738	35	geometry	geometry	NN
cord-001835-0s7ok4uw	3738	36	.	.	.
cord-001835-0s7ok4uw	3739	1	Generation	generation	NN
cord-001835-0s7ok4uw	3739	2	of	of	IN
cord-001835-0s7ok4uw	3739	3	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	3739	4	protein	protein	NN
cord-001835-0s7ok4uw	3739	5	-	-	HYPH
cord-001835-0s7ok4uw	3739	6	tagged	tag	VBN
cord-001835-0s7ok4uw	3739	7	gp120	gp120	NNP
cord-001835-0s7ok4uw	3739	8	mutants	mutant	NNS
cord-001835-0s7ok4uw	3739	9	to	to	TO
cord-001835-0s7ok4uw	3739	10	analyze	analyze	VB
cord-001835-0s7ok4uw	3739	11	the	the	DT
cord-001835-0s7ok4uw	3739	12	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3739	13	distribution	distribution	NN
cord-001835-0s7ok4uw	3739	14	of	of	IN
cord-001835-0s7ok4uw	3739	15	HIV-1	HIV-1	NNP
cord-001835-0s7ok4uw	3739	16	envelope	envelope	NN
cord-001835-0s7ok4uw	3739	17	protein	protein	NN
cord-001835-0s7ok4uw	3739	18	Shuhei	Shuhei	NNP
cord-001835-0s7ok4uw	3739	19	Nakane	Nakane	NNP
cord-001835-0s7ok4uw	3739	20	1	1	CD
cord-001835-0s7ok4uw	3739	21	,	,	,
cord-001835-0s7ok4uw	3739	22	Zene	Zene	NNP
cord-001835-0s7ok4uw	3739	23	Matsuda	Matsuda	NNP
cord-001835-0s7ok4uw	3739	24	3	3	CD
cord-001835-0s7ok4uw	3739	25	1	1	CD
cord-001835-0s7ok4uw	3739	26	Green	Green	NNP
cord-001835-0s7ok4uw	3739	27	Earth	Earth	NNP
cord-001835-0s7ok4uw	3739	28	Research	Research	NNP
cord-001835-0s7ok4uw	3739	29	Center	Center	NNP
cord-001835-0s7ok4uw	3739	30	,	,	,
cord-001835-0s7ok4uw	3739	31	Green	Green	NNP
cord-001835-0s7ok4uw	3739	32	Earth	Earth	NNP
cord-001835-0s7ok4uw	3739	33	Institute	Institute	NNP
cord-001835-0s7ok4uw	3739	34	Co.	Co.	NNP
cord-001835-0s7ok4uw	3739	35	,	,	,
cord-001835-0s7ok4uw	3739	36	Ltd.	Ltd.	NNP
cord-001835-0s7ok4uw	3739	37	,	,	,
cord-001835-0s7ok4uw	3739	38	2	2	CD
cord-001835-0s7ok4uw	3739	39	Res	Res	NNP
cord-001835-0s7ok4uw	3739	40	Ctr	Ctr	NNP
cord-001835-0s7ok4uw	3739	41	for	for	IN
cord-001835-0s7ok4uw	3739	42	Asian	asian	JJ
cord-001835-0s7ok4uw	3739	43	Infect	infect	NN
cord-001835-0s7ok4uw	3739	44	Dis	Dis	NNP
cord-001835-0s7ok4uw	3739	45	,	,	,
cord-001835-0s7ok4uw	3739	46	Inst	Inst	NNP
cord-001835-0s7ok4uw	3739	47	of	of	IN
cord-001835-0s7ok4uw	3739	48	Med	Med	NNP
cord-001835-0s7ok4uw	3739	49	Sci	Sci	NNP
cord-001835-0s7ok4uw	3739	50	,	,	,
cord-001835-0s7ok4uw	3739	51	the	the	DT
cord-001835-0s7ok4uw	3739	52	Univ	Univ	NNP
cord-001835-0s7ok4uw	3739	53	of	of	IN
cord-001835-0s7ok4uw	3739	54	Tokyo	Tokyo	NNP
cord-001835-0s7ok4uw	3739	55	,	,	,
cord-001835-0s7ok4uw	3739	56	3	3	CD
cord-001835-0s7ok4uw	3739	57	Lab	Lab	NNP
cord-001835-0s7ok4uw	3739	58	of	of	IN
cord-001835-0s7ok4uw	3739	59	Struct	Struct	NNP
cord-001835-0s7ok4uw	3739	60	Virol	Virol	NNP
cord-001835-0s7ok4uw	3739	61	and	and	CC
cord-001835-0s7ok4uw	3739	62	Immunol	Immunol	NNP
cord-001835-0s7ok4uw	3739	63	,	,	,
cord-001835-0s7ok4uw	3739	64	Institute	Institute	NNP
cord-001835-0s7ok4uw	3739	65	of	of	IN
cord-001835-0s7ok4uw	3739	66	Biophysics	Biophysics	NNP
cord-001835-0s7ok4uw	3739	67	,	,	,
cord-001835-0s7ok4uw	3739	68	CAS	CAS	NNP
cord-001835-0s7ok4uw	3739	69	HIV-1	HIV-1	NNP
cord-001835-0s7ok4uw	3739	70	is	be	VBZ
cord-001835-0s7ok4uw	3739	71	a	a	DT
cord-001835-0s7ok4uw	3739	72	causative	causative	JJ
cord-001835-0s7ok4uw	3739	73	enveloped	envelop	VBN
cord-001835-0s7ok4uw	3739	74	virus	virus	NN
cord-001835-0s7ok4uw	3739	75	of	of	IN
cord-001835-0s7ok4uw	3739	76	AIDS	AIDS	NNP
cord-001835-0s7ok4uw	3739	77	.	.	.
cord-001835-0s7ok4uw	3740	1	Its	-PRON-	PRP$
cord-001835-0s7ok4uw	3740	2	envelope	envelope	NN
cord-001835-0s7ok4uw	3740	3	protein	protein	NN
cord-001835-0s7ok4uw	3740	4	(	(	-LRB-
cord-001835-0s7ok4uw	3740	5	Env	Env	NNP
cord-001835-0s7ok4uw	3740	6	)	)	-RRB-
cord-001835-0s7ok4uw	3740	7	has	have	VBZ
cord-001835-0s7ok4uw	3740	8	two	two	CD
cord-001835-0s7ok4uw	3740	9	non	non	JJ
cord-001835-0s7ok4uw	3740	10	-	-	JJ
cord-001835-0s7ok4uw	3740	11	covalently	covalently	RB
cord-001835-0s7ok4uw	3740	12	associated	associate	VBN
cord-001835-0s7ok4uw	3740	13	subunits	subunit	NNS
cord-001835-0s7ok4uw	3740	14	,	,	,
cord-001835-0s7ok4uw	3740	15	gp120	gp120	NNP
cord-001835-0s7ok4uw	3740	16	and	and	CC
cord-001835-0s7ok4uw	3740	17	gp41	gp41	NNP
cord-001835-0s7ok4uw	3740	18	,	,	,
cord-001835-0s7ok4uw	3740	19	which	which	WDT
cord-001835-0s7ok4uw	3740	20	are	be	VBP
cord-001835-0s7ok4uw	3740	21	proteolytically	proteolytically	RB
cord-001835-0s7ok4uw	3740	22	processed	process	VBN
cord-001835-0s7ok4uw	3740	23	from	from	IN
cord-001835-0s7ok4uw	3740	24	a	a	DT
cord-001835-0s7ok4uw	3740	25	gp160	gp160	NNP
cord-001835-0s7ok4uw	3740	26	precursor	precursor	NN
cord-001835-0s7ok4uw	3740	27	.	.	.
cord-001835-0s7ok4uw	3741	1	The	the	DT
cord-001835-0s7ok4uw	3741	2	gp120	gp120	NNP
cord-001835-0s7ok4uw	3741	3	subunit	subunit	NN
cord-001835-0s7ok4uw	3741	4	is	be	VBZ
cord-001835-0s7ok4uw	3741	5	a	a	DT
cord-001835-0s7ok4uw	3741	6	surface	surface	NN
cord-001835-0s7ok4uw	3741	7	protein	protein	NN
cord-001835-0s7ok4uw	3741	8	and	and	CC
cord-001835-0s7ok4uw	3741	9	gp41	gp41	NNP
cord-001835-0s7ok4uw	3741	10	is	be	VBZ
cord-001835-0s7ok4uw	3741	11	a	a	DT
cord-001835-0s7ok4uw	3741	12	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	3741	13	protein	protein	NN
cord-001835-0s7ok4uw	3741	14	.	.	.
cord-001835-0s7ok4uw	3742	1	The	the	DT
cord-001835-0s7ok4uw	3742	2	gp120	gp120	NN
cord-001835-0s7ok4uw	3742	3	and	and	CC
cord-001835-0s7ok4uw	3742	4	gp41	gp41	NNP
cord-001835-0s7ok4uw	3742	5	subunits	subunit	NNS
cord-001835-0s7ok4uw	3742	6	are	be	VBP
cord-001835-0s7ok4uw	3742	7	responsible	responsible	JJ
cord-001835-0s7ok4uw	3742	8	for	for	IN
cord-001835-0s7ok4uw	3742	9	the	the	DT
cord-001835-0s7ok4uw	3742	10	receptor	receptor	NN
cord-001835-0s7ok4uw	3742	11	recognition	recognition	NN
cord-001835-0s7ok4uw	3742	12	and	and	CC
cord-001835-0s7ok4uw	3742	13	membrane	membrane	NN
cord-001835-0s7ok4uw	3742	14	fusion	fusion	NN
cord-001835-0s7ok4uw	3742	15	,	,	,
cord-001835-0s7ok4uw	3742	16	respectively	respectively	RB
cord-001835-0s7ok4uw	3742	17	.	.	.
cord-001835-0s7ok4uw	3743	1	The	the	DT
cord-001835-0s7ok4uw	3743	2	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	3743	3	tail	tail	NN
cord-001835-0s7ok4uw	3743	4	(	(	-LRB-
cord-001835-0s7ok4uw	3743	5	CT	CT	NNP
cord-001835-0s7ok4uw	3743	6	)	)	-RRB-
cord-001835-0s7ok4uw	3743	7	of	of	IN
cord-001835-0s7ok4uw	3743	8	gp41	gp41	NNP
cord-001835-0s7ok4uw	3743	9	is	be	VBZ
cord-001835-0s7ok4uw	3743	10	about	about	RB
cord-001835-0s7ok4uw	3743	11	150	150	CD
cord-001835-0s7ok4uw	3743	12	amino	amino	JJ
cord-001835-0s7ok4uw	3743	13	acids	acid	NNS
cord-001835-0s7ok4uw	3743	14	long	long	RB
cord-001835-0s7ok4uw	3743	15	and	and	CC
cord-001835-0s7ok4uw	3743	16	is	be	VBZ
cord-001835-0s7ok4uw	3743	17	believed	believe	VBN
cord-001835-0s7ok4uw	3743	18	to	to	TO
cord-001835-0s7ok4uw	3743	19	play	play	VB
cord-001835-0s7ok4uw	3743	20	a	a	DT
cord-001835-0s7ok4uw	3743	21	critical	critical	JJ
cord-001835-0s7ok4uw	3743	22	role	role	NN
cord-001835-0s7ok4uw	3743	23	in	in	IN
cord-001835-0s7ok4uw	3743	24	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3743	25	trafficking	trafficking	NN
cord-001835-0s7ok4uw	3743	26	of	of	IN
cord-001835-0s7ok4uw	3743	27	Env	Env	NNP
cord-001835-0s7ok4uw	3743	28	.	.	.
cord-001835-0s7ok4uw	3744	1	To	to	TO
cord-001835-0s7ok4uw	3744	2	visualize	visualize	VB
cord-001835-0s7ok4uw	3744	3	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	3744	4	trafficking	trafficking	NN
cord-001835-0s7ok4uw	3744	5	,	,	,
cord-001835-0s7ok4uw	3744	6	the	the	DT
cord-001835-0s7ok4uw	3744	7	C	c	NN
cord-001835-0s7ok4uw	3744	8	-	-	HYPH
cord-001835-0s7ok4uw	3744	9	terminus	terminus	NN
cord-001835-0s7ok4uw	3744	10	of	of	IN
cord-001835-0s7ok4uw	3744	11	gp41	gp41	NNP
cord-001835-0s7ok4uw	3744	12	has	have	VBZ
cord-001835-0s7ok4uw	3744	13	been	be	VBN
cord-001835-0s7ok4uw	3744	14	tagged	tag	VBN
cord-001835-0s7ok4uw	3744	15	with	with	IN
cord-001835-0s7ok4uw	3744	16	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	3744	17	proteins	protein	NNS
cord-001835-0s7ok4uw	3744	18	such	such	JJ
cord-001835-0s7ok4uw	3744	19	as	as	IN
cord-001835-0s7ok4uw	3744	20	GFP	GFP	NNP
cord-001835-0s7ok4uw	3744	21	.	.	.
cord-001835-0s7ok4uw	3745	1	However	however	RB
cord-001835-0s7ok4uw	3745	2	,	,	,
cord-001835-0s7ok4uw	3745	3	tagging	tagging	NN
cord-001835-0s7ok4uw	3745	4	of	of	IN
cord-001835-0s7ok4uw	3745	5	CT	CT	NNP
cord-001835-0s7ok4uw	3745	6	may	may	MD
cord-001835-0s7ok4uw	3745	7	cause	cause	VB
cord-001835-0s7ok4uw	3745	8	a	a	DT
cord-001835-0s7ok4uw	3745	9	concern	concern	NN
cord-001835-0s7ok4uw	3745	10	to	to	TO
cord-001835-0s7ok4uw	3745	11	affect	affect	VB
cord-001835-0s7ok4uw	3745	12	the	the	DT
cord-001835-0s7ok4uw	3745	13	interactions	interaction	NNS
cord-001835-0s7ok4uw	3745	14	between	between	IN
cord-001835-0s7ok4uw	3745	15	the	the	DT
cord-001835-0s7ok4uw	3745	16	CT	CT	NNP
cord-001835-0s7ok4uw	3745	17	and	and	CC
cord-001835-0s7ok4uw	3745	18	cellular	cellular	JJ
cord-001835-0s7ok4uw	3745	19	proteins	protein	NNS
cord-001835-0s7ok4uw	3745	20	that	that	WDT
cord-001835-0s7ok4uw	3745	21	are	be	VBP
cord-001835-0s7ok4uw	3745	22	involved	involve	VBN
cord-001835-0s7ok4uw	3745	23	in	in	IN
cord-001835-0s7ok4uw	3745	24	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3745	25	trafficking	trafficking	NN
cord-001835-0s7ok4uw	3745	26	.	.	.
cord-001835-0s7ok4uw	3746	1	To	to	TO
cord-001835-0s7ok4uw	3746	2	avoid	avoid	VB
cord-001835-0s7ok4uw	3746	3	this	this	DT
cord-001835-0s7ok4uw	3746	4	problem	problem	NN
cord-001835-0s7ok4uw	3746	5	,	,	,
cord-001835-0s7ok4uw	3746	6	here	here	RB
cord-001835-0s7ok4uw	3746	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	3746	8	tried	try	VBD
cord-001835-0s7ok4uw	3746	9	to	to	TO
cord-001835-0s7ok4uw	3746	10	insert	insert	VB
cord-001835-0s7ok4uw	3746	11	GFPopt	GFPopt	NNP
cord-001835-0s7ok4uw	3746	12	,	,	,
cord-001835-0s7ok4uw	3746	13	a	a	DT
cord-001835-0s7ok4uw	3746	14	GFP	GFP	NNP
cord-001835-0s7ok4uw	3746	15	variant	variant	NN
cord-001835-0s7ok4uw	3746	16	,	,	,
cord-001835-0s7ok4uw	3746	17	into	into	IN
cord-001835-0s7ok4uw	3746	18	five	five	CD
cord-001835-0s7ok4uw	3746	19	variable	variable	JJ
cord-001835-0s7ok4uw	3746	20	regions	region	NNS
cord-001835-0s7ok4uw	3746	21	of	of	IN
cord-001835-0s7ok4uw	3746	22	gp120	gp120	CD
cord-001835-0s7ok4uw	3746	23	.	.	.
cord-001835-0s7ok4uw	3747	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3747	2	have	have	VBP
cord-001835-0s7ok4uw	3747	3	analyzed	analyze	VBN
cord-001835-0s7ok4uw	3747	4	the	the	DT
cord-001835-0s7ok4uw	3747	5	phenotypes	phenotype	NNS
cord-001835-0s7ok4uw	3747	6	of	of	IN
cord-001835-0s7ok4uw	3747	7	Env	Env	NNP
cord-001835-0s7ok4uw	3747	8	mutants	mutant	NNS
cord-001835-0s7ok4uw	3747	9	,	,	,
cord-001835-0s7ok4uw	3747	10	such	such	JJ
cord-001835-0s7ok4uw	3747	11	as	as	IN
cord-001835-0s7ok4uw	3747	12	the	the	DT
cord-001835-0s7ok4uw	3747	13	cell	cell	NN
cord-001835-0s7ok4uw	3747	14	surface	surface	NN
cord-001835-0s7ok4uw	3747	15	expression	expression	NN
cord-001835-0s7ok4uw	3747	16	,	,	,
cord-001835-0s7ok4uw	3747	17	processing	processing	NN
cord-001835-0s7ok4uw	3747	18	of	of	IN
cord-001835-0s7ok4uw	3747	19	gp160	gp160	NNP
cord-001835-0s7ok4uw	3747	20	,	,	,
cord-001835-0s7ok4uw	3747	21	membrane	membrane	NN
cord-001835-0s7ok4uw	3747	22	fusion	fusion	NN
cord-001835-0s7ok4uw	3747	23	activity	activity	NN
cord-001835-0s7ok4uw	3747	24	,	,	,
cord-001835-0s7ok4uw	3747	25	and	and	CC
cord-001835-0s7ok4uw	3747	26	virion	virion	NN
cord-001835-0s7ok4uw	3747	27	incorporation	incorporation	NN
cord-001835-0s7ok4uw	3747	28	.	.	.
cord-001835-0s7ok4uw	3748	1	Among	among	IN
cord-001835-0s7ok4uw	3748	2	5	5	CD
cord-001835-0s7ok4uw	3748	3	variable	variable	JJ
cord-001835-0s7ok4uw	3748	4	regions	region	NNS
cord-001835-0s7ok4uw	3748	5	of	of	IN
cord-001835-0s7ok4uw	3748	6	gp120	gp120	CD
cord-001835-0s7ok4uw	3748	7	,	,	,
cord-001835-0s7ok4uw	3748	8	the	the	DT
cord-001835-0s7ok4uw	3748	9	V3	V3	NNP
cord-001835-0s7ok4uw	3748	10	region	region	NN
cord-001835-0s7ok4uw	3748	11	was	be	VBD
cord-001835-0s7ok4uw	3748	12	most	most	RBS
cord-001835-0s7ok4uw	3748	13	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	3748	14	to	to	IN
cord-001835-0s7ok4uw	3748	15	insertion	insertion	NN
cord-001835-0s7ok4uw	3748	16	.	.	.
cord-001835-0s7ok4uw	3749	1	V1	V1	NNP
cord-001835-0s7ok4uw	3749	2	/	/	SYM
cord-001835-0s7ok4uw	3749	3	V2	v2	NN
cord-001835-0s7ok4uw	3749	4	region	region	NN
cord-001835-0s7ok4uw	3749	5	was	be	VBD
cord-001835-0s7ok4uw	3749	6	less	less	RBR
cord-001835-0s7ok4uw	3749	7	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	3749	8	than	than	IN
cord-001835-0s7ok4uw	3749	9	V3	V3	NNP
cord-001835-0s7ok4uw	3749	10	.	.	.
cord-001835-0s7ok4uw	3750	1	Consistent	consistent	JJ
cord-001835-0s7ok4uw	3750	2	with	with	IN
cord-001835-0s7ok4uw	3750	3	the	the	DT
cord-001835-0s7ok4uw	3750	4	recently	recently	RB
cord-001835-0s7ok4uw	3750	5	revealed	reveal	VBN
cord-001835-0s7ok4uw	3750	6	structure	structure	NN
cord-001835-0s7ok4uw	3750	7	,	,	,
cord-001835-0s7ok4uw	3750	8	exteriorly	exteriorly	RB
cord-001835-0s7ok4uw	3750	9	located	locate	VBN
cord-001835-0s7ok4uw	3750	10	V4	V4	NNP
cord-001835-0s7ok4uw	3750	11	and	and	CC
cord-001835-0s7ok4uw	3750	12	V5	V5	NNP
cord-001835-0s7ok4uw	3750	13	were	be	VBD
cord-001835-0s7ok4uw	3750	14	highly	highly	RB
cord-001835-0s7ok4uw	3750	15	tolerant	tolerant	JJ
cord-001835-0s7ok4uw	3750	16	to	to	IN
cord-001835-0s7ok4uw	3750	17	insertion	insertion	NN
cord-001835-0s7ok4uw	3750	18	.	.	.
cord-001835-0s7ok4uw	3751	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3751	2	used	use	VBD
cord-001835-0s7ok4uw	3751	3	the	the	DT
cord-001835-0s7ok4uw	3751	4	mutant	mutant	NN
cord-001835-0s7ok4uw	3751	5	with	with	IN
cord-001835-0s7ok4uw	3751	6	the	the	DT
cord-001835-0s7ok4uw	3751	7	GFP	GFP	NNP
cord-001835-0s7ok4uw	3751	8	insertion	insertion	NN
cord-001835-0s7ok4uw	3751	9	in	in	IN
cord-001835-0s7ok4uw	3751	10	the	the	DT
cord-001835-0s7ok4uw	3751	11	V5	V5	NNP
cord-001835-0s7ok4uw	3751	12	region	region	NN
cord-001835-0s7ok4uw	3751	13	to	to	TO
cord-001835-0s7ok4uw	3751	14	analyze	analyze	VB
cord-001835-0s7ok4uw	3751	15	the	the	DT
cord-001835-0s7ok4uw	3751	16	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3751	17	distribution	distribution	NN
cord-001835-0s7ok4uw	3751	18	of	of	IN
cord-001835-0s7ok4uw	3751	19	Env	Env	NNP
cord-001835-0s7ok4uw	3751	20	with	with	IN
cord-001835-0s7ok4uw	3751	21	and	and	CC
cord-001835-0s7ok4uw	3751	22	without	without	IN
cord-001835-0s7ok4uw	3751	23	CT	CT	NNP
cord-001835-0s7ok4uw	3751	24	.	.	.
cord-001835-0s7ok4uw	3752	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3752	2	found	find	VBD
cord-001835-0s7ok4uw	3752	3	that	that	IN
cord-001835-0s7ok4uw	3752	4	deletion	deletion	NN
cord-001835-0s7ok4uw	3752	5	of	of	IN
cord-001835-0s7ok4uw	3752	6	CT	CT	NNP
cord-001835-0s7ok4uw	3752	7	increased	increase	VBD
cord-001835-0s7ok4uw	3752	8	the	the	DT
cord-001835-0s7ok4uw	3752	9	presence	presence	NN
cord-001835-0s7ok4uw	3752	10	of	of	IN
cord-001835-0s7ok4uw	3752	11	vesicles	vesicle	NNS
cord-001835-0s7ok4uw	3752	12	colocalized	colocalize	VBN
cord-001835-0s7ok4uw	3752	13	with	with	IN
cord-001835-0s7ok4uw	3752	14	late	late	JJ
cord-001835-0s7ok4uw	3752	15	endosome	endosome	NN
cord-001835-0s7ok4uw	3752	16	markers	marker	NNS
cord-001835-0s7ok4uw	3752	17	.	.	.
cord-001835-0s7ok4uw	3753	1	This	this	DT
cord-001835-0s7ok4uw	3753	2	is	be	VBZ
cord-001835-0s7ok4uw	3753	3	consistent	consistent	JJ
cord-001835-0s7ok4uw	3753	4	with	with	IN
cord-001835-0s7ok4uw	3753	5	the	the	DT
cord-001835-0s7ok4uw	3753	6	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	3753	7	that	that	IN
cord-001835-0s7ok4uw	3753	8	the	the	DT
cord-001835-0s7ok4uw	3753	9	CT	CT	NNP
cord-001835-0s7ok4uw	3753	10	region	region	NN
cord-001835-0s7ok4uw	3753	11	contains	contain	VBZ
cord-001835-0s7ok4uw	3753	12	a	a	DT
cord-001835-0s7ok4uw	3753	13	motif	motif	NN
cord-001835-0s7ok4uw	3753	14	regulating	regulate	VBG
cord-001835-0s7ok4uw	3753	15	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3753	16	trafficking	trafficking	NN
cord-001835-0s7ok4uw	3753	17	.	.	.
cord-001835-0s7ok4uw	3754	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3754	2	results	result	NNS
cord-001835-0s7ok4uw	3754	3	showed	show	VBD
cord-001835-0s7ok4uw	3754	4	that	that	IN
cord-001835-0s7ok4uw	3754	5	Env	Env	NNP
cord-001835-0s7ok4uw	3754	6	with	with	IN
cord-001835-0s7ok4uw	3754	7	GFPopt	gfpopt	CD
cord-001835-0s7ok4uw	3754	8	insertion	insertion	NN
cord-001835-0s7ok4uw	3754	9	in	in	IN
cord-001835-0s7ok4uw	3754	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3754	11	gp120	gp120	NNP
cord-001835-0s7ok4uw	3754	12	subunit	subunit	NN
cord-001835-0s7ok4uw	3754	13	is	be	VBZ
cord-001835-0s7ok4uw	3754	14	a	a	DT
cord-001835-0s7ok4uw	3754	15	useful	useful	JJ
cord-001835-0s7ok4uw	3754	16	tool	tool	NN
cord-001835-0s7ok4uw	3754	17	for	for	IN
cord-001835-0s7ok4uw	3754	18	the	the	DT
cord-001835-0s7ok4uw	3754	19	study	study	NN
cord-001835-0s7ok4uw	3754	20	of	of	IN
cord-001835-0s7ok4uw	3754	21	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3754	22	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3754	23	of	of	IN
cord-001835-0s7ok4uw	3754	24	HIV-1	HIV-1	NNP
cord-001835-0s7ok4uw	3754	25	Env	Env	NNP
cord-001835-0s7ok4uw	3754	26	.	.	.
cord-001835-0s7ok4uw	3755	1	These	these	DT
cord-001835-0s7ok4uw	3755	2	mutants	mutant	NNS
cord-001835-0s7ok4uw	3755	3	would	would	MD
cord-001835-0s7ok4uw	3755	4	also	also	RB
cord-001835-0s7ok4uw	3755	5	be	be	VB
cord-001835-0s7ok4uw	3755	6	useful	useful	JJ
cord-001835-0s7ok4uw	3755	7	to	to	TO
cord-001835-0s7ok4uw	3755	8	trace	trace	VB
cord-001835-0s7ok4uw	3755	9	the	the	DT
cord-001835-0s7ok4uw	3755	10	fate	fate	NN
cord-001835-0s7ok4uw	3755	11	of	of	IN
cord-001835-0s7ok4uw	3755	12	virus	virus	NN
cord-001835-0s7ok4uw	3755	13	particles	particle	NNS
cord-001835-0s7ok4uw	3755	14	during	during	IN
cord-001835-0s7ok4uw	3755	15	infection	infection	NN
cord-001835-0s7ok4uw	3755	16	.	.	.
cord-001835-0s7ok4uw	3756	1	PI-055	pi-055	DT
cord-001835-0s7ok4uw	3756	2	NGS	NGS	NNP
cord-001835-0s7ok4uw	3756	3	-	-	HYPH
cord-001835-0s7ok4uw	3756	4	guided	guide	VBN
cord-001835-0s7ok4uw	3756	5	phage	phage	NN
cord-001835-0s7ok4uw	3756	6	panning	panning	NN
cord-001835-0s7ok4uw	3756	7	:	:	:
cord-001835-0s7ok4uw	3756	8	Comparison	comparison	NN
cord-001835-0s7ok4uw	3756	9	to	to	IN
cord-001835-0s7ok4uw	3756	10	conventional	conventional	JJ
cord-001835-0s7ok4uw	3756	11	panning	panning	NN
cord-001835-0s7ok4uw	3756	12	strategy	strategy	NN
cord-001835-0s7ok4uw	3756	13	Buyung	Buyung	NNP
cord-001835-0s7ok4uw	3756	14	Santoso	Santoso	NNP
cord-001835-0s7ok4uw	3756	15	1	1	CD
cord-001835-0s7ok4uw	3756	16	,	,	,
cord-001835-0s7ok4uw	3756	17	Dorain	Dorain	NNP
cord-001835-0s7ok4uw	3756	18	Thompson	Thompson	NNP
cord-001835-0s7ok4uw	3756	19	1	1	CD
cord-001835-0s7ok4uw	3756	20	,	,	,
cord-001835-0s7ok4uw	3756	21	John	John	NNP
cord-001835-0s7ok4uw	3756	22	Nuss	Nuss	NNP
cord-001835-0s7ok4uw	3756	23	1	1	CD
cord-001835-0s7ok4uw	3757	1	,	,	,
cord-001835-0s7ok4uw	3757	2	John	John	NNP
cord-001835-0s7ok4uw	3757	3	Dwyer	Dwyer	NNP
cord-001835-0s7ok4uw	3757	4	1	1	CD
cord-001835-0s7ok4uw	3757	5	1	1	CD
cord-001835-0s7ok4uw	3757	6	Phage	Phage	NNP
cord-001835-0s7ok4uw	3757	7	display	display	NN
cord-001835-0s7ok4uw	3757	8	is	be	VBZ
cord-001835-0s7ok4uw	3757	9	a	a	DT
cord-001835-0s7ok4uw	3757	10	powerful	powerful	JJ
cord-001835-0s7ok4uw	3757	11	tool	tool	NN
cord-001835-0s7ok4uw	3757	12	for	for	IN
cord-001835-0s7ok4uw	3757	13	generating	generate	VBG
cord-001835-0s7ok4uw	3757	14	binders	binder	NNS
cord-001835-0s7ok4uw	3757	15	to	to	IN
cord-001835-0s7ok4uw	3757	16	a	a	DT
cord-001835-0s7ok4uw	3757	17	target	target	NN
cord-001835-0s7ok4uw	3757	18	protein	protein	NN
cord-001835-0s7ok4uw	3757	19	.	.	.
cord-001835-0s7ok4uw	3758	1	Multiple	multiple	JJ
cord-001835-0s7ok4uw	3758	2	rounds	round	NNS
cord-001835-0s7ok4uw	3758	3	of	of	IN
cord-001835-0s7ok4uw	3758	4	panning	pan	VBG
cord-001835-0s7ok4uw	3758	5	with	with	IN
cord-001835-0s7ok4uw	3758	6	conventional	conventional	JJ
cord-001835-0s7ok4uw	3758	7	phage	phage	NN
cord-001835-0s7ok4uw	3758	8	display	display	NN
cord-001835-0s7ok4uw	3758	9	strategies	strategy	NNS
cord-001835-0s7ok4uw	3758	10	typically	typically	RB
cord-001835-0s7ok4uw	3758	11	result	result	VBP
cord-001835-0s7ok4uw	3758	12	in	in	IN
cord-001835-0s7ok4uw	3758	13	a	a	DT
cord-001835-0s7ok4uw	3758	14	number	number	NN
cord-001835-0s7ok4uw	3758	15	of	of	IN
cord-001835-0s7ok4uw	3758	16	hits	hit	NNS
cord-001835-0s7ok4uw	3758	17	,	,	,
cord-001835-0s7ok4uw	3758	18	which	which	WDT
cord-001835-0s7ok4uw	3758	19	are	be	VBP
cord-001835-0s7ok4uw	3758	20	then	then	RB
cord-001835-0s7ok4uw	3758	21	individually	individually	RB
cord-001835-0s7ok4uw	3758	22	screened	screen	VBN
cord-001835-0s7ok4uw	3758	23	using	use	VBG
cord-001835-0s7ok4uw	3758	24	in	in	IN
cord-001835-0s7ok4uw	3758	25	vitro	vitro	FW
cord-001835-0s7ok4uw	3758	26	assays	assay	NNS
cord-001835-0s7ok4uw	3758	27	.	.	.
cord-001835-0s7ok4uw	3759	1	Clones	clone	NNS
cord-001835-0s7ok4uw	3759	2	screened	screen	VBN
cord-001835-0s7ok4uw	3759	3	at	at	IN
cord-001835-0s7ok4uw	3759	4	this	this	DT
cord-001835-0s7ok4uw	3759	5	stage	stage	NN
cord-001835-0s7ok4uw	3759	6	are	be	VBP
cord-001835-0s7ok4uw	3759	7	a	a	DT
cord-001835-0s7ok4uw	3759	8	combination	combination	NN
cord-001835-0s7ok4uw	3759	9	of	of	IN
cord-001835-0s7ok4uw	3759	10	specific	specific	JJ
cord-001835-0s7ok4uw	3759	11	binders	binder	NNS
cord-001835-0s7ok4uw	3759	12	,	,	,
cord-001835-0s7ok4uw	3759	13	sequences	sequence	NNS
cord-001835-0s7ok4uw	3759	14	that	that	WDT
cord-001835-0s7ok4uw	3759	15	are	be	VBP
cord-001835-0s7ok4uw	3759	16	selected	select	VBN
cord-001835-0s7ok4uw	3759	17	due	due	IN
cord-001835-0s7ok4uw	3759	18	to	to	IN
cord-001835-0s7ok4uw	3759	19	amplification	amplification	NN
cord-001835-0s7ok4uw	3759	20	bias	bias	NN
cord-001835-0s7ok4uw	3759	21	,	,	,
cord-001835-0s7ok4uw	3759	22	and	and	CC
cord-001835-0s7ok4uw	3759	23	non	non	JJ
cord-001835-0s7ok4uw	3759	24	-	-	JJ
cord-001835-0s7ok4uw	3759	25	specific	specific	JJ
cord-001835-0s7ok4uw	3759	26	binders	binder	NNS
cord-001835-0s7ok4uw	3759	27	.	.	.
cord-001835-0s7ok4uw	3760	1	If	if	IN
cord-001835-0s7ok4uw	3760	2	the	the	DT
cord-001835-0s7ok4uw	3760	3	number	number	NN
cord-001835-0s7ok4uw	3760	4	of	of	IN
cord-001835-0s7ok4uw	3760	5	specific	specific	JJ
cord-001835-0s7ok4uw	3760	6	clones	clone	NNS
cord-001835-0s7ok4uw	3760	7	is	be	VBZ
cord-001835-0s7ok4uw	3760	8	low	low	JJ
cord-001835-0s7ok4uw	3760	9	relative	relative	JJ
cord-001835-0s7ok4uw	3760	10	to	to	IN
cord-001835-0s7ok4uw	3760	11	the	the	DT
cord-001835-0s7ok4uw	3760	12	non	non	JJ
cord-001835-0s7ok4uw	3760	13	-	-	JJ
cord-001835-0s7ok4uw	3760	14	specific	specific	JJ
cord-001835-0s7ok4uw	3760	15	sequences	sequence	NNS
cord-001835-0s7ok4uw	3760	16	,	,	,
cord-001835-0s7ok4uw	3760	17	a	a	DT
cord-001835-0s7ok4uw	3760	18	larger	large	JJR
cord-001835-0s7ok4uw	3760	19	number	number	NN
cord-001835-0s7ok4uw	3760	20	of	of	IN
cord-001835-0s7ok4uw	3760	21	clones	clone	NNS
cord-001835-0s7ok4uw	3760	22	have	have	VBP
cord-001835-0s7ok4uw	3760	23	to	to	TO
cord-001835-0s7ok4uw	3760	24	be	be	VB
cord-001835-0s7ok4uw	3760	25	screened	screen	VBN
cord-001835-0s7ok4uw	3760	26	to	to	TO
cord-001835-0s7ok4uw	3760	27	ensure	ensure	VB
cord-001835-0s7ok4uw	3760	28	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	3760	29	diversity	diversity	NN
cord-001835-0s7ok4uw	3760	30	of	of	IN
cord-001835-0s7ok4uw	3760	31	early	early	JJ
cord-001835-0s7ok4uw	3760	32	leads	lead	NNS
cord-001835-0s7ok4uw	3760	33	.	.	.
cord-001835-0s7ok4uw	3761	1	With	with	IN
cord-001835-0s7ok4uw	3761	2	the	the	DT
cord-001835-0s7ok4uw	3761	3	advent	advent	NN
cord-001835-0s7ok4uw	3761	4	of	of	IN
cord-001835-0s7ok4uw	3761	5	next	next	JJ
cord-001835-0s7ok4uw	3761	6	generation	generation	NN
cord-001835-0s7ok4uw	3761	7	sequencing	sequencing	NN
cord-001835-0s7ok4uw	3761	8	(	(	-LRB-
cord-001835-0s7ok4uw	3761	9	NGS	NGS	NNP
cord-001835-0s7ok4uw	3761	10	)	)	-RRB-
cord-001835-0s7ok4uw	3761	11	technology	technology	NN
cord-001835-0s7ok4uw	3761	12	,	,	,
cord-001835-0s7ok4uw	3761	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	3761	14	aim	aim	VBP
cord-001835-0s7ok4uw	3761	15	to	to	TO
cord-001835-0s7ok4uw	3761	16	test	test	VB
cord-001835-0s7ok4uw	3761	17	whether	whether	IN
cord-001835-0s7ok4uw	3761	18	we	-PRON-	PRP
cord-001835-0s7ok4uw	3761	19	can	can	MD
cord-001835-0s7ok4uw	3761	20	increase	increase	VB
cord-001835-0s7ok4uw	3761	21	the	the	DT
cord-001835-0s7ok4uw	3761	22	diversity	diversity	NN
cord-001835-0s7ok4uw	3761	23	of	of	IN
cord-001835-0s7ok4uw	3761	24	specific	specific	JJ
cord-001835-0s7ok4uw	3761	25	hits	hit	NNS
cord-001835-0s7ok4uw	3761	26	and	and	CC
cord-001835-0s7ok4uw	3761	27	decrease	decrease	VB
cord-001835-0s7ok4uw	3761	28	the	the	DT
cord-001835-0s7ok4uw	3761	29	number	number	NN
cord-001835-0s7ok4uw	3761	30	of	of	IN
cord-001835-0s7ok4uw	3761	31	non	non	JJ
cord-001835-0s7ok4uw	3761	32	-	-	JJ
cord-001835-0s7ok4uw	3761	33	specific	specific	JJ
cord-001835-0s7ok4uw	3761	34	sequences	sequence	NNS
cord-001835-0s7ok4uw	3761	35	.	.	.
cord-001835-0s7ok4uw	3762	1	In	in	IN
cord-001835-0s7ok4uw	3762	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3762	3	experiment	experiment	NN
cord-001835-0s7ok4uw	3762	4	,	,	,
cord-001835-0s7ok4uw	3762	5	four	four	CD
cord-001835-0s7ok4uw	3762	6	rounds	round	NNS
cord-001835-0s7ok4uw	3762	7	of	of	IN
cord-001835-0s7ok4uw	3762	8	conventional	conventional	JJ
cord-001835-0s7ok4uw	3762	9	panning	panning	NN
cord-001835-0s7ok4uw	3762	10	produced	produce	VBD
cord-001835-0s7ok4uw	3762	11	ten	ten	CD
cord-001835-0s7ok4uw	3762	12	peptide	peptide	NN
cord-001835-0s7ok4uw	3762	13	binders	binder	NNS
cord-001835-0s7ok4uw	3762	14	to	to	TO
cord-001835-0s7ok4uw	3762	15	target	target	VB
cord-001835-0s7ok4uw	3762	16	protein	protein	NN
cord-001835-0s7ok4uw	3762	17	.	.	.
cord-001835-0s7ok4uw	3763	1	NGS	NGS	NNP
cord-001835-0s7ok4uw	3763	2	analysis	analysis	NN
cord-001835-0s7ok4uw	3763	3	after	after	IN
cord-001835-0s7ok4uw	3763	4	two	two	CD
cord-001835-0s7ok4uw	3763	5	rounds	round	NNS
cord-001835-0s7ok4uw	3763	6	of	of	IN
cord-001835-0s7ok4uw	3763	7	panning	panning	NN
cord-001835-0s7ok4uw	3763	8	was	be	VBD
cord-001835-0s7ok4uw	3763	9	done	do	VBN
cord-001835-0s7ok4uw	3763	10	in	in	IN
cord-001835-0s7ok4uw	3763	11	parallel	parallel	NN
cord-001835-0s7ok4uw	3763	12	,	,	,
cord-001835-0s7ok4uw	3763	13	yielding	yield	VBG
cord-001835-0s7ok4uw	3763	14	more	more	JJR
cord-001835-0s7ok4uw	3763	15	than	than	IN
cord-001835-0s7ok4uw	3763	16	ten	ten	CD
cord-001835-0s7ok4uw	3763	17	thousand	thousand	CD
cord-001835-0s7ok4uw	3763	18	sequences	sequence	NNS
cord-001835-0s7ok4uw	3763	19	,	,	,
cord-001835-0s7ok4uw	3763	20	ranked	rank	VBN
cord-001835-0s7ok4uw	3763	21	by	by	IN
cord-001835-0s7ok4uw	3763	22	abundance	abundance	NN
cord-001835-0s7ok4uw	3763	23	.	.	.
cord-001835-0s7ok4uw	3764	1	All	all	DT
cord-001835-0s7ok4uw	3764	2	ten	ten	CD
cord-001835-0s7ok4uw	3764	3	binders	binder	NNS
cord-001835-0s7ok4uw	3764	4	from	from	IN
cord-001835-0s7ok4uw	3764	5	conventional	conventional	JJ
cord-001835-0s7ok4uw	3764	6	panning	panning	NN
cord-001835-0s7ok4uw	3764	7	were	be	VBD
cord-001835-0s7ok4uw	3764	8	found	find	VBN
cord-001835-0s7ok4uw	3764	9	in	in	IN
cord-001835-0s7ok4uw	3764	10	the	the	DT
cord-001835-0s7ok4uw	3764	11	top	top	JJ
cord-001835-0s7ok4uw	3764	12	150	150	CD
cord-001835-0s7ok4uw	3764	13	most	most	RBS
cord-001835-0s7ok4uw	3764	14	abundant	abundant	JJ
cord-001835-0s7ok4uw	3764	15	NGS	NGS	NNP
cord-001835-0s7ok4uw	3764	16	hits	hit	NNS
cord-001835-0s7ok4uw	3764	17	.	.	.
cord-001835-0s7ok4uw	3765	1	More	more	RBR
cord-001835-0s7ok4uw	3765	2	importantly	importantly	RB
cord-001835-0s7ok4uw	3765	3	,	,	,
cord-001835-0s7ok4uw	3765	4	additional	additional	JJ
cord-001835-0s7ok4uw	3765	5	hits	hit	NNS
cord-001835-0s7ok4uw	3765	6	were	be	VBD
cord-001835-0s7ok4uw	3765	7	found	find	VBN
cord-001835-0s7ok4uw	3765	8	in	in	IN
cord-001835-0s7ok4uw	3765	9	NGS	NGS	NNP
cord-001835-0s7ok4uw	3765	10	analysis	analysis	NN
cord-001835-0s7ok4uw	3765	11	but	but	CC
cord-001835-0s7ok4uw	3765	12	not	not	RB
cord-001835-0s7ok4uw	3765	13	in	in	IN
cord-001835-0s7ok4uw	3765	14	conventional	conventional	JJ
cord-001835-0s7ok4uw	3765	15	panning	panning	NN
cord-001835-0s7ok4uw	3765	16	,	,	,
cord-001835-0s7ok4uw	3765	17	highlighting	highlight	VBG
cord-001835-0s7ok4uw	3765	18	this	this	DT
cord-001835-0s7ok4uw	3765	19	strategy	strategy	NN
cord-001835-0s7ok4uw	3765	20	as	as	IN
cord-001835-0s7ok4uw	3765	21	a	a	DT
cord-001835-0s7ok4uw	3765	22	promising	promising	JJ
cord-001835-0s7ok4uw	3765	23	alternative	alternative	NN
cord-001835-0s7ok4uw	3765	24	for	for	IN
cord-001835-0s7ok4uw	3765	25	hit	hit	NN
cord-001835-0s7ok4uw	3765	26	discovery	discovery	NN
cord-001835-0s7ok4uw	3765	27	with	with	IN
cord-001835-0s7ok4uw	3765	28	the	the	DT
cord-001835-0s7ok4uw	3765	29	significant	significant	JJ
cord-001835-0s7ok4uw	3765	30	upside	upside	NN
cord-001835-0s7ok4uw	3765	31	of	of	IN
cord-001835-0s7ok4uw	3765	32	more	more	RBR
cord-001835-0s7ok4uw	3765	33	diverse	diverse	JJ
cord-001835-0s7ok4uw	3765	34	and	and	CC
cord-001835-0s7ok4uw	3765	35	higher	high	JJR
cord-001835-0s7ok4uw	3765	36	affinity	affinity	NN
cord-001835-0s7ok4uw	3765	37	leads	lead	VBZ
cord-001835-0s7ok4uw	3765	38	.	.	.
cord-001835-0s7ok4uw	3765	39	 	 	_SP
cord-001835-0s7ok4uw	3766	1	Numerous	numerous	JJ
cord-001835-0s7ok4uw	3766	2	processes	process	NNS
cord-001835-0s7ok4uw	3766	3	in	in	IN
cord-001835-0s7ok4uw	3766	4	pharmaceutical	pharmaceutical	JJ
cord-001835-0s7ok4uw	3766	5	development	development	NN
cord-001835-0s7ok4uw	3766	6	,	,	,
cord-001835-0s7ok4uw	3766	7	including	include	VBG
cord-001835-0s7ok4uw	3766	8	construct	construct	NN
cord-001835-0s7ok4uw	3766	9	screening	screening	NN
cord-001835-0s7ok4uw	3766	10	,	,	,
cord-001835-0s7ok4uw	3766	11	structural	structural	JJ
cord-001835-0s7ok4uw	3766	12	genomics	genomic	NNS
cord-001835-0s7ok4uw	3766	13	,	,	,
cord-001835-0s7ok4uw	3766	14	protein	protein	NN
cord-001835-0s7ok4uw	3766	15	engineering	engineering	NN
cord-001835-0s7ok4uw	3766	16	and	and	CC
cord-001835-0s7ok4uw	3766	17	expression	expression	NN
cord-001835-0s7ok4uw	3766	18	optimization	optimization	NN
cord-001835-0s7ok4uw	3766	19	among	among	IN
cord-001835-0s7ok4uw	3766	20	others	other	NNS
cord-001835-0s7ok4uw	3766	21	,	,	,
cord-001835-0s7ok4uw	3766	22	require	require	VB
cord-001835-0s7ok4uw	3766	23	the	the	DT
cord-001835-0s7ok4uw	3766	24	use	use	NN
cord-001835-0s7ok4uw	3766	25	of	of	IN
cord-001835-0s7ok4uw	3766	26	higher	high	JJR
cord-001835-0s7ok4uw	3766	27	throughput	throughput	NN
cord-001835-0s7ok4uw	3766	28	plasmid	plasmid	NN
cord-001835-0s7ok4uw	3766	29	DNA	dna	NN
cord-001835-0s7ok4uw	3766	30	purification	purification	NN
cord-001835-0s7ok4uw	3766	31	.	.	.
cord-001835-0s7ok4uw	3767	1	The	the	DT
cord-001835-0s7ok4uw	3767	2	majority	majority	NN
cord-001835-0s7ok4uw	3767	3	of	of	IN
cord-001835-0s7ok4uw	3767	4	issues	issue	NNS
cord-001835-0s7ok4uw	3767	5	encountered	encounter	VBN
cord-001835-0s7ok4uw	3767	6	in	in	IN
cord-001835-0s7ok4uw	3767	7	Mini	Mini	NNP
cord-001835-0s7ok4uw	3767	8	,	,	,
cord-001835-0s7ok4uw	3767	9	Midi	Midi	NNP
cord-001835-0s7ok4uw	3767	10	,	,	,
cord-001835-0s7ok4uw	3767	11	and	and	CC
cord-001835-0s7ok4uw	3767	12	Maxiprep	Maxiprep	NNP
cord-001835-0s7ok4uw	3767	13	purification	purification	NN
cord-001835-0s7ok4uw	3767	14	kits	kit	NNS
cord-001835-0s7ok4uw	3767	15	involve	involve	VBP
cord-001835-0s7ok4uw	3767	16	flocculate	flocculate	VBP
cord-001835-0s7ok4uw	3767	17	removal	removal	NN
cord-001835-0s7ok4uw	3767	18	following	follow	VBG
cord-001835-0s7ok4uw	3767	19	alkaline	alkaline	JJ
cord-001835-0s7ok4uw	3767	20	lysis	lysis	NN
cord-001835-0s7ok4uw	3767	21	,	,	,
cord-001835-0s7ok4uw	3767	22	and	and	CC
cord-001835-0s7ok4uw	3767	23	there	there	EX
cord-001835-0s7ok4uw	3767	24	is	be	VBZ
cord-001835-0s7ok4uw	3767	25	currently	currently	RB
cord-001835-0s7ok4uw	3767	26	no	no	DT
cord-001835-0s7ok4uw	3767	27	easy	easy	JJ
cord-001835-0s7ok4uw	3767	28	way	way	NN
cord-001835-0s7ok4uw	3767	29	to	to	TO
cord-001835-0s7ok4uw	3767	30	produce	produce	VB
cord-001835-0s7ok4uw	3767	31	large	large	JJ
cord-001835-0s7ok4uw	3767	32	amounts	amount	NNS
cord-001835-0s7ok4uw	3767	33	of	of	IN
cord-001835-0s7ok4uw	3767	34	plasmid	plasmid	NN
cord-001835-0s7ok4uw	3767	35	DNA	dna	NN
cord-001835-0s7ok4uw	3767	36	without	without	IN
cord-001835-0s7ok4uw	3767	37	the	the	DT
cord-001835-0s7ok4uw	3767	38	addition	addition	NN
cord-001835-0s7ok4uw	3767	39	of	of	IN
cord-001835-0s7ok4uw	3767	40	complicated	complicated	JJ
cord-001835-0s7ok4uw	3767	41	and	and	CC
cord-001835-0s7ok4uw	3767	42	time	time	NN
cord-001835-0s7ok4uw	3767	43	consuming	consume	VBG
cord-001835-0s7ok4uw	3767	44	clarification	clarification	NN
cord-001835-0s7ok4uw	3767	45	steps	step	NNS
cord-001835-0s7ok4uw	3767	46	.	.	.
cord-001835-0s7ok4uw	3768	1	The	the	DT
cord-001835-0s7ok4uw	3768	2	existence	existence	NN
cord-001835-0s7ok4uw	3768	3	of	of	IN
cord-001835-0s7ok4uw	3768	4	a	a	DT
cord-001835-0s7ok4uw	3768	5	hassle	hassle	NN
cord-001835-0s7ok4uw	3768	6	-	-	HYPH
cord-001835-0s7ok4uw	3768	7	free	free	JJ
cord-001835-0s7ok4uw	3768	8	automated	automate	VBN
cord-001835-0s7ok4uw	3768	9	system	system	NN
cord-001835-0s7ok4uw	3768	10	that	that	WDT
cord-001835-0s7ok4uw	3768	11	is	be	VBZ
cord-001835-0s7ok4uw	3768	12	not	not	RB
cord-001835-0s7ok4uw	3768	13	restricted	restrict	VBN
cord-001835-0s7ok4uw	3768	14	by	by	IN
cord-001835-0s7ok4uw	3768	15	sample	sample	NN
cord-001835-0s7ok4uw	3768	16	size	size	NN
cord-001835-0s7ok4uw	3768	17	would	would	MD
cord-001835-0s7ok4uw	3768	18	significantly	significantly	RB
cord-001835-0s7ok4uw	3768	19	help	help	VB
cord-001835-0s7ok4uw	3768	20	in	in	IN
cord-001835-0s7ok4uw	3768	21	cutting	cut	VBG
cord-001835-0s7ok4uw	3768	22	time	time	NN
cord-001835-0s7ok4uw	3768	23	and	and	CC
cord-001835-0s7ok4uw	3768	24	costs	cost	NNS
cord-001835-0s7ok4uw	3768	25	during	during	IN
cord-001835-0s7ok4uw	3768	26	the	the	DT
cord-001835-0s7ok4uw	3768	27	initial	initial	JJ
cord-001835-0s7ok4uw	3768	28	processing	processing	NN
cord-001835-0s7ok4uw	3768	29	steps	step	NNS
cord-001835-0s7ok4uw	3768	30	of	of	IN
cord-001835-0s7ok4uw	3768	31	plasmid	plasmid	NN
cord-001835-0s7ok4uw	3768	32	purification	purification	NN
cord-001835-0s7ok4uw	3768	33	.	.	.
cord-001835-0s7ok4uw	3769	1	The	the	DT
cord-001835-0s7ok4uw	3769	2	AutoPlasmid	AutoPlasmid	NNP
cord-001835-0s7ok4uw	3769	3	MEA	mea	NN
cord-001835-0s7ok4uw	3769	4	instrument	instrument	NN
cord-001835-0s7ok4uw	3769	5	provides	provide	VBZ
cord-001835-0s7ok4uw	3769	6	a	a	DT
cord-001835-0s7ok4uw	3769	7	fully	fully	RB
cord-001835-0s7ok4uw	3769	8	automated	automate	VBN
cord-001835-0s7ok4uw	3769	9	solution	solution	NN
cord-001835-0s7ok4uw	3769	10	to	to	IN
cord-001835-0s7ok4uw	3769	11	traditional	traditional	JJ
cord-001835-0s7ok4uw	3769	12	problems	problem	NNS
cord-001835-0s7ok4uw	3769	13	faced	face	VBN
cord-001835-0s7ok4uw	3769	14	in	in	IN
cord-001835-0s7ok4uw	3769	15	plasmid	plasmid	NN
cord-001835-0s7ok4uw	3769	16	purifications	purification	NNS
cord-001835-0s7ok4uw	3769	17	,	,	,
cord-001835-0s7ok4uw	3769	18	allowing	allow	VBG
cord-001835-0s7ok4uw	3769	19	Mini	Mini	NNP
cord-001835-0s7ok4uw	3769	20	,	,	,
cord-001835-0s7ok4uw	3769	21	Midi	Midi	NNP
cord-001835-0s7ok4uw	3769	22	,	,	,
cord-001835-0s7ok4uw	3769	23	and	and	CC
cord-001835-0s7ok4uw	3769	24	Maxiprep	Maxiprep	NNP
cord-001835-0s7ok4uw	3769	25	plasmid	plasmid	NN
cord-001835-0s7ok4uw	3769	26	purifications	purification	NNS
cord-001835-0s7ok4uw	3769	27	to	to	TO
cord-001835-0s7ok4uw	3769	28	be	be	VB
cord-001835-0s7ok4uw	3769	29	performed	perform	VBN
cord-001835-0s7ok4uw	3769	30	on	on	IN
cord-001835-0s7ok4uw	3769	31	a	a	DT
cord-001835-0s7ok4uw	3769	32	single	single	JJ
cord-001835-0s7ok4uw	3769	33	instrument	instrument	NN
cord-001835-0s7ok4uw	3769	34	.	.	.
cord-001835-0s7ok4uw	3770	1	The	the	DT
cord-001835-0s7ok4uw	3770	2	data	datum	NNS
cord-001835-0s7ok4uw	3770	3	presented	present	VBN
cord-001835-0s7ok4uw	3770	4	here	here	RB
cord-001835-0s7ok4uw	3770	5	on	on	IN
cord-001835-0s7ok4uw	3770	6	plasmid	plasmid	NN
cord-001835-0s7ok4uw	3770	7	yield	yield	NN
cord-001835-0s7ok4uw	3770	8	,	,	,
cord-001835-0s7ok4uw	3770	9	purity	purity	NN
cord-001835-0s7ok4uw	3770	10	,	,	,
cord-001835-0s7ok4uw	3770	11	and	and	CC
cord-001835-0s7ok4uw	3770	12	suitability	suitability	NN
cord-001835-0s7ok4uw	3770	13	for	for	IN
cord-001835-0s7ok4uw	3770	14	sequencing	sequencing	NN
cord-001835-0s7ok4uw	3770	15	and	and	CC
cord-001835-0s7ok4uw	3770	16	transfection	transfection	NN
cord-001835-0s7ok4uw	3770	17	/	/	SYM
cord-001835-0s7ok4uw	3770	18	transformation	transformation	NN
cord-001835-0s7ok4uw	3770	19	illustrate	illustrate	VBP
cord-001835-0s7ok4uw	3770	20	a	a	DT
cord-001835-0s7ok4uw	3770	21	new	new	JJ
cord-001835-0s7ok4uw	3770	22	strategy	strategy	NN
cord-001835-0s7ok4uw	3770	23	for	for	IN
cord-001835-0s7ok4uw	3770	24	automated	automate	VBN
cord-001835-0s7ok4uw	3770	25	plasmid	plasmid	NN
cord-001835-0s7ok4uw	3770	26	preps	prep	NNS
cord-001835-0s7ok4uw	3770	27	.	.	.
cord-001835-0s7ok4uw	3771	1	By	by	IN
cord-001835-0s7ok4uw	3771	2	eliminating	eliminate	VBG
cord-001835-0s7ok4uw	3771	3	traditional	traditional	JJ
cord-001835-0s7ok4uw	3771	4	clarification	clarification	NN
cord-001835-0s7ok4uw	3771	5	methods	method	NNS
cord-001835-0s7ok4uw	3771	6	,	,	,
cord-001835-0s7ok4uw	3771	7	cell	cell	NN
cord-001835-0s7ok4uw	3771	8	culture	culture	NN
cord-001835-0s7ok4uw	3771	9	volumes	volume	NNS
cord-001835-0s7ok4uw	3771	10	between	between	IN
cord-001835-0s7ok4uw	3771	11	1	1	CD
cord-001835-0s7ok4uw	3771	12	-120	-120	NN
cord-001835-0s7ok4uw	3771	13	mL	ml	NN
cord-001835-0s7ok4uw	3771	14	can	can	MD
cord-001835-0s7ok4uw	3771	15	be	be	VB
cord-001835-0s7ok4uw	3771	16	processed	process	VBN
cord-001835-0s7ok4uw	3771	17	leading	lead	VBG
cord-001835-0s7ok4uw	3771	18	to	to	IN
cord-001835-0s7ok4uw	3771	19	yields	yield	NNS
cord-001835-0s7ok4uw	3771	20	ranging	range	VBG
cord-001835-0s7ok4uw	3771	21	from	from	IN
cord-001835-0s7ok4uw	3771	22	3	3	CD
cord-001835-0s7ok4uw	3771	23	-1000	-1000	NN
cord-001835-0s7ok4uw	3771	24	lg	lg	NNP
cord-001835-0s7ok4uw	3771	25	.	.	.
cord-001835-0s7ok4uw	3772	1	This	this	DT
cord-001835-0s7ok4uw	3772	2	flexible	flexible	JJ
cord-001835-0s7ok4uw	3772	3	system	system	NN
cord-001835-0s7ok4uw	3772	4	was	be	VBD
cord-001835-0s7ok4uw	3772	5	developed	develop	VBN
cord-001835-0s7ok4uw	3772	6	in	in	IN
cord-001835-0s7ok4uw	3772	7	order	order	NN
cord-001835-0s7ok4uw	3772	8	to	to	TO
cord-001835-0s7ok4uw	3772	9	satisfy	satisfy	VB
cord-001835-0s7ok4uw	3772	10	a	a	DT
cord-001835-0s7ok4uw	3772	11	wide	wide	JJ
cord-001835-0s7ok4uw	3772	12	variety	variety	NN
cord-001835-0s7ok4uw	3772	13	of	of	IN
cord-001835-0s7ok4uw	3772	14	concentration	concentration	NN
cord-001835-0s7ok4uw	3772	15	and	and	CC
cord-001835-0s7ok4uw	3772	16	yield	yield	NN
cord-001835-0s7ok4uw	3772	17	requirement	requirement	NN
cord-001835-0s7ok4uw	3772	18	,	,	,
cord-001835-0s7ok4uw	3772	19	while	while	IN
cord-001835-0s7ok4uw	3772	20	eliminating	eliminate	VBG
cord-001835-0s7ok4uw	3772	21	the	the	DT
cord-001835-0s7ok4uw	3772	22	time	time	NN
cord-001835-0s7ok4uw	3772	23	consuming	consume	VBG
cord-001835-0s7ok4uw	3772	24	steps	step	NNS
cord-001835-0s7ok4uw	3772	25	previously	previously	RB
cord-001835-0s7ok4uw	3772	26	needed	need	VBD
cord-001835-0s7ok4uw	3772	27	to	to	TO
cord-001835-0s7ok4uw	3772	28	obtain	obtain	VB
cord-001835-0s7ok4uw	3772	29	similar	similar	JJ
cord-001835-0s7ok4uw	3772	30	results	result	NNS
cord-001835-0s7ok4uw	3772	31	.	.	.
cord-001835-0s7ok4uw	3773	1	The	the	DT
cord-001835-0s7ok4uw	3773	2	ability	ability	NN
cord-001835-0s7ok4uw	3773	3	to	to	TO
cord-001835-0s7ok4uw	3773	4	perform	perform	VB
cord-001835-0s7ok4uw	3773	5	fully	fully	RB
cord-001835-0s7ok4uw	3773	6	automated	automate	VBN
cord-001835-0s7ok4uw	3773	7	Mini	Mini	NNP
cord-001835-0s7ok4uw	3773	8	,	,	,
cord-001835-0s7ok4uw	3773	9	Midi	Midi	NNP
cord-001835-0s7ok4uw	3773	10	,	,	,
cord-001835-0s7ok4uw	3773	11	and	and	CC
cord-001835-0s7ok4uw	3773	12	Maxi	Maxi	NNP
cord-001835-0s7ok4uw	3773	13	plasmid	plasmid	NN
cord-001835-0s7ok4uw	3773	14	preps	prep	VBZ
cord-001835-0s7ok4uw	3773	15	on	on	IN
cord-001835-0s7ok4uw	3773	16	one	one	CD
cord-001835-0s7ok4uw	3773	17	instrument	instrument	NN
cord-001835-0s7ok4uw	3773	18	allows	allow	VBZ
cord-001835-0s7ok4uw	3773	19	for	for	IN
cord-001835-0s7ok4uw	3773	20	a	a	DT
cord-001835-0s7ok4uw	3773	21	customized	customize	VBN
cord-001835-0s7ok4uw	3773	22	all	all	DT
cord-001835-0s7ok4uw	3773	23	-	-	HYPH
cord-001835-0s7ok4uw	3773	24	in	in	IN
cord-001835-0s7ok4uw	3773	25	-	-	HYPH
cord-001835-0s7ok4uw	3773	26	one	one	CD
cord-001835-0s7ok4uw	3773	27	purification	purification	NN
cord-001835-0s7ok4uw	3773	28	system	system	NN
cord-001835-0s7ok4uw	3773	29	that	that	WDT
cord-001835-0s7ok4uw	3773	30	is	be	VBZ
cord-001835-0s7ok4uw	3773	31	not	not	RB
cord-001835-0s7ok4uw	3773	32	restricted	restrict	VBN
cord-001835-0s7ok4uw	3773	33	by	by	IN
cord-001835-0s7ok4uw	3773	34	traditional	traditional	JJ
cord-001835-0s7ok4uw	3773	35	clarification	clarification	NN
cord-001835-0s7ok4uw	3773	36	methods	method	NNS
cord-001835-0s7ok4uw	3773	37	,	,	,
cord-001835-0s7ok4uw	3773	38	eliminating	eliminate	VBG
cord-001835-0s7ok4uw	3773	39	manual	manual	JJ
cord-001835-0s7ok4uw	3773	40	intervention	intervention	NN
cord-001835-0s7ok4uw	3773	41	,	,	,
cord-001835-0s7ok4uw	3773	42	and	and	CC
cord-001835-0s7ok4uw	3773	43	streamlining	streamline	VBG
cord-001835-0s7ok4uw	3773	44	the	the	DT
cord-001835-0s7ok4uw	3773	45	purification	purification	NN
cord-001835-0s7ok4uw	3773	46	process	process	NN
cord-001835-0s7ok4uw	3773	47	.	.	.
cord-001835-0s7ok4uw	3774	1	The	the	DT
cord-001835-0s7ok4uw	3774	2	modular	modular	JJ
cord-001835-0s7ok4uw	3774	3	nature	nature	NN
cord-001835-0s7ok4uw	3774	4	of	of	IN
cord-001835-0s7ok4uw	3774	5	protein	protein	NN
cord-001835-0s7ok4uw	3774	6	architectures	architecture	NNS
cord-001835-0s7ok4uw	3774	7	suggests	suggest	VBZ
cord-001835-0s7ok4uw	3774	8	that	that	IN
cord-001835-0s7ok4uw	3774	9	proteins	protein	NNS
cord-001835-0s7ok4uw	3774	10	have	have	VBP
cord-001835-0s7ok4uw	3774	11	evolved	evolve	VBN
cord-001835-0s7ok4uw	3774	12	through	through	IN
cord-001835-0s7ok4uw	3774	13	duplication	duplication	NN
cord-001835-0s7ok4uw	3774	14	and	and	CC
cord-001835-0s7ok4uw	3774	15	fusion	fusion	NN
cord-001835-0s7ok4uw	3774	16	to	to	TO
cord-001835-0s7ok4uw	3774	17	give	give	VB
cord-001835-0s7ok4uw	3774	18	rise	rise	NN
cord-001835-0s7ok4uw	3774	19	to	to	IN
cord-001835-0s7ok4uw	3774	20	modular	modular	JJ
cord-001835-0s7ok4uw	3774	21	,	,	,
cord-001835-0s7ok4uw	3774	22	often	often	RB
cord-001835-0s7ok4uw	3774	23	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	3774	24	forms	form	NNS
cord-001835-0s7ok4uw	3774	25	,	,	,
cord-001835-0s7ok4uw	3774	26	which	which	WDT
cord-001835-0s7ok4uw	3774	27	later	later	RB
cord-001835-0s7ok4uw	3774	28	diversified	diversify	VBD
cord-001835-0s7ok4uw	3774	29	under	under	IN
cord-001835-0s7ok4uw	3774	30	the	the	DT
cord-001835-0s7ok4uw	3774	31	influence	influence	NN
cord-001835-0s7ok4uw	3774	32	of	of	IN
cord-001835-0s7ok4uw	3774	33	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	3774	34	pressure	pressure	NN
cord-001835-0s7ok4uw	3774	35	.	.	.
cord-001835-0s7ok4uw	3775	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3775	2	have	have	VBP
cord-001835-0s7ok4uw	3775	3	developed	develop	VBN
cord-001835-0s7ok4uw	3775	4	a	a	DT
cord-001835-0s7ok4uw	3775	5	computational	computational	JJ
cord-001835-0s7ok4uw	3775	6	protein	protein	NN
cord-001835-0s7ok4uw	3775	7	design	design	NN
cord-001835-0s7ok4uw	3775	8	method	method	NN
cord-001835-0s7ok4uw	3775	9	termed	term	VBD
cord-001835-0s7ok4uw	3775	10	REverse	REverse	NNP
cord-001835-0s7ok4uw	3775	11	Engineer	Engineer	NNP
cord-001835-0s7ok4uw	3775	12	Evolution	Evolution	NNP
cord-001835-0s7ok4uw	3775	13	(	(	-LRB-
cord-001835-0s7ok4uw	3775	14	RE3Volution	re3volution	NN
cord-001835-0s7ok4uw	3775	15	)	)	-RRB-
cord-001835-0s7ok4uw	3775	16	to	to	TO
cord-001835-0s7ok4uw	3775	17	create	create	VB
cord-001835-0s7ok4uw	3775	18	symmetrically	symmetrically	RB
cord-001835-0s7ok4uw	3775	19	self	self	NN
cord-001835-0s7ok4uw	3775	20	-	-	HYPH
cord-001835-0s7ok4uw	3775	21	assembling	assemble	VBG
cord-001835-0s7ok4uw	3775	22	protein	protein	NN
cord-001835-0s7ok4uw	3775	23	building	building	NN
cord-001835-0s7ok4uw	3775	24	blocks	block	NNS
cord-001835-0s7ok4uw	3775	25	.	.	.
cord-001835-0s7ok4uw	3776	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3776	2	have	have	VBP
cord-001835-0s7ok4uw	3776	3	used	use	VBN
cord-001835-0s7ok4uw	3776	4	this	this	DT
cord-001835-0s7ok4uw	3776	5	method	method	NN
cord-001835-0s7ok4uw	3776	6	to	to	TO
cord-001835-0s7ok4uw	3776	7	design	design	VB
cord-001835-0s7ok4uw	3776	8	a	a	DT
cord-001835-0s7ok4uw	3776	9	perfectly	perfectly	RB
cord-001835-0s7ok4uw	3776	10	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	3776	11	b	b	NN
cord-001835-0s7ok4uw	3776	12	-	-	HYPH
cord-001835-0s7ok4uw	3776	13	propeller	propeller	NN
cord-001835-0s7ok4uw	3776	14	protein	protein	NN
cord-001835-0s7ok4uw	3776	15	called	call	VBN
cord-001835-0s7ok4uw	3776	16	Pizza	Pizza	NNP
cord-001835-0s7ok4uw	3776	17	.	.	.
cord-001835-0s7ok4uw	3777	1	Subsequently	subsequently	RB
cord-001835-0s7ok4uw	3777	2	,	,	,
cord-001835-0s7ok4uw	3777	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3777	4	have	have	VBP
cord-001835-0s7ok4uw	3777	5	engineered	engineer	VBN
cord-001835-0s7ok4uw	3777	6	a	a	DT
cord-001835-0s7ok4uw	3777	7	metal	metal	NN
cord-001835-0s7ok4uw	3777	8	binding	bind	VBG
cord-001835-0s7ok4uw	3777	9	site	site	NN
cord-001835-0s7ok4uw	3777	10	into	into	IN
cord-001835-0s7ok4uw	3777	11	this	this	DT
cord-001835-0s7ok4uw	3777	12	Pizza	Pizza	NNP
cord-001835-0s7ok4uw	3777	13	protein	protein	NN
cord-001835-0s7ok4uw	3777	14	.	.	.
cord-001835-0s7ok4uw	3778	1	This	this	DT
cord-001835-0s7ok4uw	3778	2	new	new	JJ
cord-001835-0s7ok4uw	3778	3	Pizza	Pizza	NNP
cord-001835-0s7ok4uw	3778	4	variant	variant	NN
cord-001835-0s7ok4uw	3778	5	carries	carry	VBZ
cord-001835-0s7ok4uw	3778	6	two	two	CD
cord-001835-0s7ok4uw	3778	7	nearly	nearly	RB
cord-001835-0s7ok4uw	3778	8	identical	identical	JJ
cord-001835-0s7ok4uw	3778	9	domains	domain	NNS
cord-001835-0s7ok4uw	3778	10	per	per	IN
cord-001835-0s7ok4uw	3778	11	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	3778	12	chain	chain	NN
cord-001835-0s7ok4uw	3778	13	,	,	,
cord-001835-0s7ok4uw	3778	14	and	and	CC
cord-001835-0s7ok4uw	3778	15	forms	form	VBZ
cord-001835-0s7ok4uw	3778	16	a	a	DT
cord-001835-0s7ok4uw	3778	17	trimer	trimer	NN
cord-001835-0s7ok4uw	3778	18	with	with	IN
cord-001835-0s7ok4uw	3778	19	three	three	CD
cord-001835-0s7ok4uw	3778	20	-	-	HYPH
cord-001835-0s7ok4uw	3778	21	fold	fold	NN
cord-001835-0s7ok4uw	3778	22	symmetry	symmetry	NN
cord-001835-0s7ok4uw	3778	23	.	.	.
cord-001835-0s7ok4uw	3779	1	The	the	DT
cord-001835-0s7ok4uw	3779	2	designed	design	VBN
cord-001835-0s7ok4uw	3779	3	single	single	JJ
cord-001835-0s7ok4uw	3779	4	metal	metal	NN
cord-001835-0s7ok4uw	3779	5	ion	ion	NN
cord-001835-0s7ok4uw	3779	6	binding	binding	NN
cord-001835-0s7ok4uw	3779	7	site	site	NN
cord-001835-0s7ok4uw	3779	8	lies	lie	VBZ
cord-001835-0s7ok4uw	3779	9	on	on	IN
cord-001835-0s7ok4uw	3779	10	the	the	DT
cord-001835-0s7ok4uw	3779	11	symmetry	symmetry	NN
cord-001835-0s7ok4uw	3779	12	axis	axis	NN
cord-001835-0s7ok4uw	3779	13	,	,	,
cord-001835-0s7ok4uw	3779	14	bonding	bond	VBG
cord-001835-0s7ok4uw	3779	15	the	the	DT
cord-001835-0s7ok4uw	3779	16	trimer	trimer	NN
cord-001835-0s7ok4uw	3779	17	together	together	RB
cord-001835-0s7ok4uw	3779	18	.	.	.
cord-001835-0s7ok4uw	3780	1	Two	two	CD
cord-001835-0s7ok4uw	3780	2	copies	copy	NNS
cord-001835-0s7ok4uw	3780	3	of	of	IN
cord-001835-0s7ok4uw	3780	4	the	the	DT
cord-001835-0s7ok4uw	3780	5	trimer	trimer	NN
cord-001835-0s7ok4uw	3780	6	associate	associate	NN
cord-001835-0s7ok4uw	3780	7	in	in	IN
cord-001835-0s7ok4uw	3780	8	the	the	DT
cord-001835-0s7ok4uw	3780	9	presence	presence	NN
cord-001835-0s7ok4uw	3780	10	of	of	IN
cord-001835-0s7ok4uw	3780	11	cadmium	cadmium	NN
cord-001835-0s7ok4uw	3780	12	chloride	chloride	NN
cord-001835-0s7ok4uw	3780	13	in	in	IN
cord-001835-0s7ok4uw	3780	14	solution	solution	NN
cord-001835-0s7ok4uw	3780	15	,	,	,
cord-001835-0s7ok4uw	3780	16	and	and	CC
cord-001835-0s7ok4uw	3780	17	high	high	JJ
cord-001835-0s7ok4uw	3780	18	resolution	resolution	NN
cord-001835-0s7ok4uw	3780	19	X	x	NN
cord-001835-0s7ok4uw	3780	20	-	-	NN
cord-001835-0s7ok4uw	3780	21	ray	ray	JJ
cord-001835-0s7ok4uw	3780	22	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	3780	23	analysis	analysis	NN
cord-001835-0s7ok4uw	3780	24	reveals	reveal	VBZ
cord-001835-0s7ok4uw	3780	25	a	a	DT
cord-001835-0s7ok4uw	3780	26	nano	nano	NN
cord-001835-0s7ok4uw	3780	27	-	-	HYPH
cord-001835-0s7ok4uw	3780	28	crystal	crystal	NN
cord-001835-0s7ok4uw	3780	29	of	of	IN
cord-001835-0s7ok4uw	3780	30	cadmium	cadmium	NN
cord-001835-0s7ok4uw	3780	31	chloride	chloride	NN
cord-001835-0s7ok4uw	3780	32	,	,	,
cord-001835-0s7ok4uw	3780	33	sandwiched	sandwich	VBN
cord-001835-0s7ok4uw	3780	34	between	between	IN
cord-001835-0s7ok4uw	3780	35	two	two	CD
cord-001835-0s7ok4uw	3780	36	trimers	trimer	NNS
cord-001835-0s7ok4uw	3780	37	of	of	IN
cord-001835-0s7ok4uw	3780	38	the	the	DT
cord-001835-0s7ok4uw	3780	39	protein	protein	NN
cord-001835-0s7ok4uw	3780	40	.	.	.
cord-001835-0s7ok4uw	3781	1	This	this	DT
cord-001835-0s7ok4uw	3781	2	nano	nano	NN
cord-001835-0s7ok4uw	3781	3	-	-	HYPH
cord-001835-0s7ok4uw	3781	4	crystal	crystal	NN
cord-001835-0s7ok4uw	3781	5	,	,	,
cord-001835-0s7ok4uw	3781	6	containing	contain	VBG
cord-001835-0s7ok4uw	3781	7	seven	seven	CD
cord-001835-0s7ok4uw	3781	8	cadmium	cadmium	NN
cord-001835-0s7ok4uw	3781	9	ions	ion	NNS
cord-001835-0s7ok4uw	3781	10	lying	lie	VBG
cord-001835-0s7ok4uw	3781	11	in	in	IN
cord-001835-0s7ok4uw	3781	12	a	a	DT
cord-001835-0s7ok4uw	3781	13	plane	plane	NN
cord-001835-0s7ok4uw	3781	14	and	and	CC
cord-001835-0s7ok4uw	3781	15	twelve	twelve	CD
cord-001835-0s7ok4uw	3781	16	interspersed	intersperse	VBN
cord-001835-0s7ok4uw	3781	17	chloride	chloride	NN
cord-001835-0s7ok4uw	3781	18	ions	ion	NNS
cord-001835-0s7ok4uw	3781	19	,	,	,
cord-001835-0s7ok4uw	3781	20	is	be	VBZ
cord-001835-0s7ok4uw	3781	21	the	the	DT
cord-001835-0s7ok4uw	3781	22	smallest	small	JJS
cord-001835-0s7ok4uw	3781	23	reported	report	VBN
cord-001835-0s7ok4uw	3781	24	to	to	IN
cord-001835-0s7ok4uw	3781	25	date	date	NN
cord-001835-0s7ok4uw	3781	26	.	.	.
cord-001835-0s7ok4uw	3782	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3782	2	results	result	NNS
cord-001835-0s7ok4uw	3782	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	3782	4	the	the	DT
cord-001835-0s7ok4uw	3782	5	feasibility	feasibility	NN
cord-001835-0s7ok4uw	3782	6	of	of	IN
cord-001835-0s7ok4uw	3782	7	using	use	VBG
cord-001835-0s7ok4uw	3782	8	rationally	rationally	RB
cord-001835-0s7ok4uw	3782	9	-	-	HYPH
cord-001835-0s7ok4uw	3782	10	designed	design	VBN
cord-001835-0s7ok4uw	3782	11	symmetrical	symmetrical	JJ
cord-001835-0s7ok4uw	3782	12	proteins	protein	NNS
cord-001835-0s7ok4uw	3782	13	to	to	IN
cord-001835-0s7ok4uw	3782	14	biomineralize	biomineralize	NNP
cord-001835-0s7ok4uw	3782	15	nano	nano	NNP
cord-001835-0s7ok4uw	3782	16	-	-	HYPH
cord-001835-0s7ok4uw	3782	17	crystals	crystal	NNS
cord-001835-0s7ok4uw	3782	18	with	with	IN
cord-001835-0s7ok4uw	3782	19	applications	application	NNS
cord-001835-0s7ok4uw	3782	20	in	in	IN
cord-001835-0s7ok4uw	3782	21	bionanotechnology	bionanotechnology	NN
cord-001835-0s7ok4uw	3782	22	.	.	.
cord-001835-0s7ok4uw	3783	1	Bacillus	Bacillus	NNP
cord-001835-0s7ok4uw	3783	2	licheniformis	licheniformis	NNP
cord-001835-0s7ok4uw	3784	1	Trehalose-6-phosphate	Trehalose-6-phosphate	NNP
cord-001835-0s7ok4uw	3784	2	Hydrolase	Hydrolase	NNP
cord-001835-0s7ok4uw	3784	3	structures	structure	NNS
cord-001835-0s7ok4uw	3784	4	suggest	suggest	VBP
cord-001835-0s7ok4uw	3784	5	keys	key	NNS
cord-001835-0s7ok4uw	3784	6	to	to	IN
cord-001835-0s7ok4uw	3784	7	substrate	substrate	NN
cord-001835-0s7ok4uw	3784	8	specificity	specificity	NN
cord-001835-0s7ok4uw	3785	1	Chwan	Chwan	NNP
cord-001835-0s7ok4uw	3785	2	-	-	HYPH
cord-001835-0s7ok4uw	3785	3	Deng	Deng	NNP
cord-001835-0s7ok4uw	3785	4	Hsiao	Hsiao	NNP
cord-001835-0s7ok4uw	3785	5	1	1	CD
cord-001835-0s7ok4uw	3785	6	,	,	,
cord-001835-0s7ok4uw	3785	7	Min	Min	NNP
cord-001835-0s7ok4uw	3785	8	-	-	HYPH
cord-001835-0s7ok4uw	3785	9	Guan	Guan	NNP
cord-001835-0s7ok4uw	3785	10	Lin	Lin	NNP
cord-001835-0s7ok4uw	3785	11	1	1	CD
cord-001835-0s7ok4uw	3786	1	,	,	,
cord-001835-0s7ok4uw	3786	2	Long	Long	NNP
cord-001835-0s7ok4uw	3786	3	-	-	HYPH
cord-001835-0s7ok4uw	3786	4	Liu	Liu	NNP
cord-001835-0s7ok4uw	3786	5	Lin	Lin	NNP
cord-001835-0s7ok4uw	3786	6	2	2	CD
cord-001835-0s7ok4uw	3786	7	,	,	,
cord-001835-0s7ok4uw	3786	8	Yuh	Yuh	NNP
cord-001835-0s7ok4uw	3786	9	-	-	HYPH
cord-001835-0s7ok4uw	3786	10	Ju	Ju	NNP
cord-001835-0s7ok4uw	3786	11	Sun	Sun	NNP
cord-001835-0s7ok4uw	3786	12	3	3	CD
cord-001835-0s7ok4uw	3786	13	1	1	CD
cord-001835-0s7ok4uw	3786	14	Institute	Institute	NNP
cord-001835-0s7ok4uw	3786	15	of	of	IN
cord-001835-0s7ok4uw	3786	16	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	3786	17	Biology	Biology	NNP
cord-001835-0s7ok4uw	3786	18	,	,	,
cord-001835-0s7ok4uw	3786	19	Academia	Academia	NNP
cord-001835-0s7ok4uw	3786	20	Sinica	Sinica	NNP
cord-001835-0s7ok4uw	3786	21	,	,	,
cord-001835-0s7ok4uw	3786	22	2	2	CD
cord-001835-0s7ok4uw	3786	23	Department	Department	NNP
cord-001835-0s7ok4uw	3786	24	of	of	IN
cord-001835-0s7ok4uw	3786	25	Applied	Applied	NNP
cord-001835-0s7ok4uw	3786	26	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	3786	27	,	,	,
cord-001835-0s7ok4uw	3786	28	National	National	NNP
cord-001835-0s7ok4uw	3786	29	Chiayi	Chiayi	NNP
cord-001835-0s7ok4uw	3786	30	University	University	NNP
cord-001835-0s7ok4uw	3786	31	,	,	,
cord-001835-0s7ok4uw	3787	1	3	3	CD
cord-001835-0s7ok4uw	3787	2	Depaertment	Depaertment	NNP
cord-001835-0s7ok4uw	3787	3	of	of	IN
cord-001835-0s7ok4uw	3787	4	Life	Life	NNP
cord-001835-0s7ok4uw	3787	5	Science	Science	NNP
cord-001835-0s7ok4uw	3787	6	,	,	,
cord-001835-0s7ok4uw	3787	7	National	National	NNP
cord-001835-0s7ok4uw	3787	8	Tsing	Tsing	NNP
cord-001835-0s7ok4uw	3787	9	Hua	Hua	NNP
cord-001835-0s7ok4uw	3787	10	University	University	NNP
cord-001835-0s7ok4uw	3787	11	Trehalose-6-phosphate	Trehalose-6-phosphate	NNP
cord-001835-0s7ok4uw	3787	12	hydrolase	hydrolase	NN
cord-001835-0s7ok4uw	3787	13	(	(	-LRB-
cord-001835-0s7ok4uw	3787	14	TreA	TreA	NNP
cord-001835-0s7ok4uw	3787	15	)	)	-RRB-
cord-001835-0s7ok4uw	3787	16	of	of	IN
cord-001835-0s7ok4uw	3787	17	the	the	DT
cord-001835-0s7ok4uw	3787	18	glycoside	glycoside	NN
cord-001835-0s7ok4uw	3787	19	hydrolase	hydrolase	NN
cord-001835-0s7ok4uw	3787	20	family	family	NN
cord-001835-0s7ok4uw	3787	21	13	13	CD
cord-001835-0s7ok4uw	3787	22	(	(	-LRB-
cord-001835-0s7ok4uw	3787	23	GH13	GH13	NNP
cord-001835-0s7ok4uw	3787	24	)	)	-RRB-
cord-001835-0s7ok4uw	3787	25	catalyzes	catalyze	VBZ
cord-001835-0s7ok4uw	3787	26	the	the	DT
cord-001835-0s7ok4uw	3787	27	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	3787	28	of	of	IN
cord-001835-0s7ok4uw	3787	29	trehalose-6-phosphate	trehalose-6-phosphate	NNP
cord-001835-0s7ok4uw	3787	30	(	(	-LRB-
cord-001835-0s7ok4uw	3787	31	T6P	t6p	NN
cord-001835-0s7ok4uw	3787	32	)	)	-RRB-
cord-001835-0s7ok4uw	3787	33	to	to	TO
cord-001835-0s7ok4uw	3787	34	yield	yield	VB
cord-001835-0s7ok4uw	3787	35	glucose	glucose	NN
cord-001835-0s7ok4uw	3787	36	and	and	CC
cord-001835-0s7ok4uw	3787	37	glucose-6-phosphate	glucose-6-phosphate	NN
cord-001835-0s7ok4uw	3787	38	.	.	.
cord-001835-0s7ok4uw	3788	1	Products	product	NNS
cord-001835-0s7ok4uw	3788	2	of	of	IN
cord-001835-0s7ok4uw	3788	3	this	this	DT
cord-001835-0s7ok4uw	3788	4	reaction	reaction	NN
cord-001835-0s7ok4uw	3788	5	can	can	MD
cord-001835-0s7ok4uw	3788	6	be	be	VB
cord-001835-0s7ok4uw	3788	7	further	further	RB
cord-001835-0s7ok4uw	3788	8	metabolized	metabolize	VBN
cord-001835-0s7ok4uw	3788	9	by	by	IN
cord-001835-0s7ok4uw	3788	10	the	the	DT
cord-001835-0s7ok4uw	3788	11	energy	energy	NN
cord-001835-0s7ok4uw	3788	12	-	-	HYPH
cord-001835-0s7ok4uw	3788	13	generating	generate	VBG
cord-001835-0s7ok4uw	3788	14	glycolytic	glycolytic	JJ
cord-001835-0s7ok4uw	3788	15	pathway	pathway	NN
cord-001835-0s7ok4uw	3788	16	.	.	.
cord-001835-0s7ok4uw	3789	1	Here	here	RB
cord-001835-0s7ok4uw	3789	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3789	3	present	present	VBP
cord-001835-0s7ok4uw	3789	4	the	the	DT
cord-001835-0s7ok4uw	3789	5	crystal	crystal	NN
cord-001835-0s7ok4uw	3789	6	structures	structure	NNS
cord-001835-0s7ok4uw	3789	7	of	of	IN
cord-001835-0s7ok4uw	3789	8	Bacillus	bacillus	NN
cord-001835-0s7ok4uw	3790	1	licheniformis	licheniformis	NNP
cord-001835-0s7ok4uw	3790	2	TreA	TreA	NNP
cord-001835-0s7ok4uw	3790	3	(	(	-LRB-
cord-001835-0s7ok4uw	3790	4	BlTreA	BlTreA	NNP
cord-001835-0s7ok4uw	3790	5	)	)	-RRB-
cord-001835-0s7ok4uw	3790	6	and	and	CC
cord-001835-0s7ok4uw	3790	7	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3790	8	R201Q	r201q	NN
cord-001835-0s7ok4uw	3790	9	mutant	mutant	NN
cord-001835-0s7ok4uw	3790	10	complexed	complexe	VBN
cord-001835-0s7ok4uw	3790	11	with	with	IN
cord-001835-0s7ok4uw	3790	12	p	p	NN
cord-001835-0s7ok4uw	3790	13	-	-	HYPH
cord-001835-0s7ok4uw	3790	14	nitrophenyl	nitrophenyl	NN
cord-001835-0s7ok4uw	3790	15	-	-	HYPH
cord-001835-0s7ok4uw	3790	16	a	a	DT
cord-001835-0s7ok4uw	3790	17	-	-	HYPH
cord-001835-0s7ok4uw	3790	18	D	d	NN
cord-001835-0s7ok4uw	3790	19	-	-	HYPH
cord-001835-0s7ok4uw	3790	20	glucopyranoside	glucopyranoside	NN
cord-001835-0s7ok4uw	3790	21	(	(	-LRB-
cord-001835-0s7ok4uw	3790	22	R201Q/	r201q/	NN
cord-001835-0s7ok4uw	3790	23	pPNG	ppng	CD
cord-001835-0s7ok4uw	3790	24	)	)	-RRB-
cord-001835-0s7ok4uw	3791	1	at	at	IN
cord-001835-0s7ok4uw	3791	2	2.0	2.0	CD
cord-001835-0s7ok4uw	3791	3	Å	å	NN
cord-001835-0s7ok4uw	3791	4	and	and	CC
cord-001835-0s7ok4uw	3791	5	2.05	2.05	CD
cord-001835-0s7ok4uw	3791	6	Å	å	NN
cord-001835-0s7ok4uw	3791	7	resolution	resolution	NN
cord-001835-0s7ok4uw	3791	8	,	,	,
cord-001835-0s7ok4uw	3791	9	respectively	respectively	RB
cord-001835-0s7ok4uw	3791	10	.	.	.
cord-001835-0s7ok4uw	3792	1	The	the	DT
cord-001835-0s7ok4uw	3792	2	overall	overall	JJ
cord-001835-0s7ok4uw	3792	3	structure	structure	NN
cord-001835-0s7ok4uw	3792	4	of	of	IN
cord-001835-0s7ok4uw	3792	5	BlTreA	BlTreA	NNP
cord-001835-0s7ok4uw	3792	6	is	be	VBZ
cord-001835-0s7ok4uw	3792	7	similar	similar	JJ
cord-001835-0s7ok4uw	3792	8	to	to	IN
cord-001835-0s7ok4uw	3792	9	other	other	JJ
cord-001835-0s7ok4uw	3792	10	GH13	GH13	NNP
cord-001835-0s7ok4uw	3792	11	family	family	NN
cord-001835-0s7ok4uw	3792	12	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3792	13	.	.	.
cord-001835-0s7ok4uw	3793	1	However	however	RB
cord-001835-0s7ok4uw	3793	2	,	,	,
cord-001835-0s7ok4uw	3793	3	detailed	detailed	JJ
cord-001835-0s7ok4uw	3793	4	structural	structural	JJ
cord-001835-0s7ok4uw	3793	5	comparisons	comparison	NNS
cord-001835-0s7ok4uw	3793	6	revealed	reveal	VBD
cord-001835-0s7ok4uw	3793	7	that	that	IN
cord-001835-0s7ok4uw	3793	8	the	the	DT
cord-001835-0s7ok4uw	3793	9	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3793	10	groove	groove	NN
cord-001835-0s7ok4uw	3793	11	of	of	IN
cord-001835-0s7ok4uw	3793	12	BlTreA	BlTreA	NNP
cord-001835-0s7ok4uw	3793	13	contains	contain	VBZ
cord-001835-0s7ok4uw	3793	14	a	a	DT
cord-001835-0s7ok4uw	3793	15	long	long	JJ
cord-001835-0s7ok4uw	3793	16	loop	loop	NN
cord-001835-0s7ok4uw	3793	17	adopting	adopt	VBG
cord-001835-0s7ok4uw	3793	18	a	a	DT
cord-001835-0s7ok4uw	3793	19	different	different	JJ
cord-001835-0s7ok4uw	3793	20	conformation	conformation	NN
cord-001835-0s7ok4uw	3793	21	from	from	IN
cord-001835-0s7ok4uw	3793	22	those	those	DT
cord-001835-0s7ok4uw	3793	23	of	of	IN
cord-001835-0s7ok4uw	3793	24	GH13	GH13	NNP
cord-001835-0s7ok4uw	3793	25	family	family	NN
cord-001835-0s7ok4uw	3793	26	members	member	NNS
cord-001835-0s7ok4uw	3793	27	.	.	.
cord-001835-0s7ok4uw	3794	1	Unlike	unlike	IN
cord-001835-0s7ok4uw	3794	2	the	the	DT
cord-001835-0s7ok4uw	3794	3	homologous	homologous	JJ
cord-001835-0s7ok4uw	3794	4	regions	region	NNS
cord-001835-0s7ok4uw	3794	5	of	of	IN
cord-001835-0s7ok4uw	3794	6	Bacillus	bacillus	NN
cord-001835-0s7ok4uw	3794	7	cereus	cereus	NN
cord-001835-0s7ok4uw	3794	8	oligo-1,6-glucosidase	oligo-1,6-glucosidase	RB
cord-001835-0s7ok4uw	3795	1	(	(	-LRB-
cord-001835-0s7ok4uw	3795	2	BcOgl	BcOgl	NNP
cord-001835-0s7ok4uw	3795	3	)	)	-RRB-
cord-001835-0s7ok4uw	3795	4	and	and	CC
cord-001835-0s7ok4uw	3795	5	Erwinia	Erwinia	NNP
cord-001835-0s7ok4uw	3795	6	rhapontici	rhapontici	NNP
cord-001835-0s7ok4uw	3795	7	isomaltulose	isomaltulose	NNP
cord-001835-0s7ok4uw	3796	1	synthase	synthase	NNP
cord-001835-0s7ok4uw	3796	2	(	(	-LRB-
cord-001835-0s7ok4uw	3796	3	NX-5	NX-5	NNP
cord-001835-0s7ok4uw	3796	4	)	)	-RRB-
cord-001835-0s7ok4uw	3796	5	,	,	,
cord-001835-0s7ok4uw	3796	6	the	the	DT
cord-001835-0s7ok4uw	3796	7	active	active	JJ
cord-001835-0s7ok4uw	3796	8	site	site	NN
cord-001835-0s7ok4uw	3796	9	surface	surface	NN
cord-001835-0s7ok4uw	3796	10	potential	potential	NN
cord-001835-0s7ok4uw	3796	11	of	of	IN
cord-001835-0s7ok4uw	3796	12	BlTreA	BlTreA	NNP
cord-001835-0s7ok4uw	3796	13	exhibits	exhibit	VBZ
cord-001835-0s7ok4uw	3796	14	a	a	DT
cord-001835-0s7ok4uw	3796	15	largely	largely	RB
cord-001835-0s7ok4uw	3796	16	positive	positive	JJ
cord-001835-0s7ok4uw	3796	17	charge	charge	NN
cord-001835-0s7ok4uw	3796	18	,	,	,
cord-001835-0s7ok4uw	3796	19	contributed	contribute	VBN
cord-001835-0s7ok4uw	3796	20	by	by	IN
cord-001835-0s7ok4uw	3796	21	the	the	DT
cord-001835-0s7ok4uw	3796	22	four	four	CD
cord-001835-0s7ok4uw	3796	23	basic	basic	JJ
cord-001835-0s7ok4uw	3796	24	residues	residue	NNS
cord-001835-0s7ok4uw	3796	25	His281	his281	ADD
cord-001835-0s7ok4uw	3796	26	,	,	,
cord-001835-0s7ok4uw	3796	27	His282	his282	ADD
cord-001835-0s7ok4uw	3796	28	,	,	,
cord-001835-0s7ok4uw	3797	1	Lys284	Lys284	NNP
cord-001835-0s7ok4uw	3797	2	and	and	CC
cord-001835-0s7ok4uw	3797	3	Lys292	lys292	ADD
cord-001835-0s7ok4uw	3797	4	.	.	.
cord-001835-0s7ok4uw	3798	1	Mutations	mutation	NNS
cord-001835-0s7ok4uw	3798	2	at	at	IN
cord-001835-0s7ok4uw	3798	3	these	these	DT
cord-001835-0s7ok4uw	3798	4	residues	residue	NNS
cord-001835-0s7ok4uw	3798	5	resulted	result	VBD
cord-001835-0s7ok4uw	3798	6	in	in	IN
cord-001835-0s7ok4uw	3798	7	significant	significant	JJ
cord-001835-0s7ok4uw	3798	8	decreases	decrease	NNS
cord-001835-0s7ok4uw	3798	9	of	of	IN
cord-001835-0s7ok4uw	3798	10	BlTreA	BlTreA	NNP
cord-001835-0s7ok4uw	3798	11	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	3798	12	activity	activity	NN
cord-001835-0s7ok4uw	3798	13	.	.	.
cord-001835-0s7ok4uw	3799	1	Strikingly	strikingly	RB
cord-001835-0s7ok4uw	3799	2	,	,	,
cord-001835-0s7ok4uw	3799	3	a	a	DT
cord-001835-0s7ok4uw	3799	4	281HHLK284	281hhlk284	CD
cord-001835-0s7ok4uw	3799	5	motif	motif	NN
cord-001835-0s7ok4uw	3799	6	and	and	CC
cord-001835-0s7ok4uw	3799	7	the	the	DT
cord-001835-0s7ok4uw	3799	8	Lys292	Lys292	NNP
cord-001835-0s7ok4uw	3799	9	residue	residue	NN
cord-001835-0s7ok4uw	3799	10	played	play	VBD
cord-001835-0s7ok4uw	3799	11	critical	critical	JJ
cord-001835-0s7ok4uw	3799	12	roles	role	NNS
cord-001835-0s7ok4uw	3799	13	in	in	IN
cord-001835-0s7ok4uw	3799	14	BlTreA	BlTreA	NNP
cord-001835-0s7ok4uw	3799	15	substrate	substrate	NN
cord-001835-0s7ok4uw	3799	16	discrimination	discrimination	NN
cord-001835-0s7ok4uw	3799	17	.	.	.
cord-001835-0s7ok4uw	3800	1	Crystal	crystal	NN
cord-001835-0s7ok4uw	3800	2	structure	structure	NN
cord-001835-0s7ok4uw	3800	3	of	of	IN
cord-001835-0s7ok4uw	3800	4	engineered	engineer	VBN
cord-001835-0s7ok4uw	3800	5	LRRTM2	LRRTM2	NNP
cord-001835-0s7ok4uw	3800	6	synaptic	synaptic	JJ
cord-001835-0s7ok4uw	3800	7	adhesion	adhesion	NN
cord-001835-0s7ok4uw	3800	8	molecule	molecule	NN
cord-001835-0s7ok4uw	3800	9	and	and	CC
cord-001835-0s7ok4uw	3800	10	a	a	DT
cord-001835-0s7ok4uw	3800	11	model	model	NN
cord-001835-0s7ok4uw	3800	12	for	for	IN
cord-001835-0s7ok4uw	3800	13	neurexin	neurexin	NNP
cord-001835-0s7ok4uw	3800	14	binding	bind	VBG
cord-001835-0s7ok4uw	3800	15	Anja	Anja	NNP
cord-001835-0s7ok4uw	3800	16	Paatero	Paatero	NNP
cord-001835-0s7ok4uw	3800	17	1	1	CD
cord-001835-0s7ok4uw	3800	18	,	,	,
cord-001835-0s7ok4uw	3800	19	Katja	Katja	NNP
cord-001835-0s7ok4uw	3800	20	Rosti	Rosti	NNP
cord-001835-0s7ok4uw	3800	21	1	1	CD
cord-001835-0s7ok4uw	3800	22	,	,	,
cord-001835-0s7ok4uw	3800	23	Alexander	Alexander	NNP
cord-001835-0s7ok4uw	3800	24	Shkumatov	Shkumatov	NNP
cord-001835-0s7ok4uw	3800	25	2	2	CD
cord-001835-0s7ok4uw	3800	26	,	,	,
cord-001835-0s7ok4uw	3800	27	Cecilia	Cecilia	NNP
cord-001835-0s7ok4uw	3800	28	Brunello	Brunello	NNP
cord-001835-0s7ok4uw	3800	29	3	3	CD
cord-001835-0s7ok4uw	3800	30	,	,	,
cord-001835-0s7ok4uw	3800	31	Kai	Kai	NNP
cord-001835-0s7ok4uw	3800	32	Kysenius	Kysenius	NNP
cord-001835-0s7ok4uw	3800	33	3	3	CD
cord-001835-0s7ok4uw	3800	34	,	,	,
cord-001835-0s7ok4uw	3800	35	Prosanta	Prosanta	NNP
cord-001835-0s7ok4uw	3800	36	Singha	Singha	NNP
cord-001835-0s7ok4uw	3800	37	1	1	CD
cord-001835-0s7ok4uw	3800	38	,	,	,
cord-001835-0s7ok4uw	3800	39	Henri	Henri	NNP
cord-001835-0s7ok4uw	3800	40	Huttunen	Huttunen	NNP
cord-001835-0s7ok4uw	3800	41	3	3	CD
cord-001835-0s7ok4uw	3800	42	,	,	,
cord-001835-0s7ok4uw	3800	43	Tommi	Tommi	NNP
cord-001835-0s7ok4uw	3800	44	Kajander	Kajander	NNP
cord-001835-0s7ok4uw	3800	45	1	1	CD
cord-001835-0s7ok4uw	3800	46	1	1	CD
cord-001835-0s7ok4uw	3800	47	Institute	Institute	NNP
cord-001835-0s7ok4uw	3800	48	of	of	IN
cord-001835-0s7ok4uw	3800	49	Biotechnology	Biotechnology	NNP
cord-001835-0s7ok4uw	3800	50	,	,	,
cord-001835-0s7ok4uw	3800	51	University	University	NNP
cord-001835-0s7ok4uw	3800	52	of	of	IN
cord-001835-0s7ok4uw	3800	53	Helsinki	Helsinki	NNP
cord-001835-0s7ok4uw	3800	54	,	,	,
cord-001835-0s7ok4uw	3800	55	Helsinki	Helsinki	NNP
cord-001835-0s7ok4uw	3800	56	,	,	,
cord-001835-0s7ok4uw	3800	57	Finland	Finland	NNP
cord-001835-0s7ok4uw	3800	58	,	,	,
cord-001835-0s7ok4uw	3800	59	2	2	CD
cord-001835-0s7ok4uw	3800	60	Dept	Dept	NNP
cord-001835-0s7ok4uw	3800	61	of	of	IN
cord-001835-0s7ok4uw	3800	62	Pharmaceutical	Pharmaceutical	NNP
cord-001835-0s7ok4uw	3800	63	and	and	CC
cord-001835-0s7ok4uw	3800	64	Pharmacological	Pharmacological	NNP
cord-001835-0s7ok4uw	3800	65	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	3800	66	,	,	,
cord-001835-0s7ok4uw	3800	67	KU	KU	NNP
cord-001835-0s7ok4uw	3800	68	Leuven	Leuven	NNP
cord-001835-0s7ok4uw	3800	69	,	,	,
cord-001835-0s7ok4uw	3800	70	Leuven	Leuven	NNP
cord-001835-0s7ok4uw	3800	71	,	,	,
cord-001835-0s7ok4uw	3800	72	Belgium	Belgium	NNP
cord-001835-0s7ok4uw	3800	73	,	,	,
cord-001835-0s7ok4uw	3800	74	3	3	CD
cord-001835-0s7ok4uw	3800	75	Neuroscience	Neuroscience	NNP
cord-001835-0s7ok4uw	3800	76	Center	Center	NNP
cord-001835-0s7ok4uw	3800	77	,	,	,
cord-001835-0s7ok4uw	3800	78	University	University	NNP
cord-001835-0s7ok4uw	3800	79	of	of	IN
cord-001835-0s7ok4uw	3800	80	Helsinki	Helsinki	NNP
cord-001835-0s7ok4uw	3800	81	Synaptic	synaptic	JJ
cord-001835-0s7ok4uw	3800	82	adhesion	adhesion	NN
cord-001835-0s7ok4uw	3800	83	molecules	molecule	NNS
cord-001835-0s7ok4uw	3800	84	are	be	VBP
cord-001835-0s7ok4uw	3800	85	key	key	JJ
cord-001835-0s7ok4uw	3800	86	components	component	NNS
cord-001835-0s7ok4uw	3800	87	in	in	IN
cord-001835-0s7ok4uw	3800	88	the	the	DT
cord-001835-0s7ok4uw	3800	89	development	development	NN
cord-001835-0s7ok4uw	3800	90	of	of	IN
cord-001835-0s7ok4uw	3800	91	the	the	DT
cord-001835-0s7ok4uw	3800	92	brain	brain	NN
cord-001835-0s7ok4uw	3800	93	,	,	,
cord-001835-0s7ok4uw	3800	94	and	and	CC
cord-001835-0s7ok4uw	3800	95	in	in	IN
cord-001835-0s7ok4uw	3800	96	the	the	DT
cord-001835-0s7ok4uw	3800	97	formation	formation	NN
cord-001835-0s7ok4uw	3800	98	of	of	IN
cord-001835-0s7ok4uw	3800	99	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	3800	100	circuits	circuit	NNS
cord-001835-0s7ok4uw	3800	101	,	,	,
cord-001835-0s7ok4uw	3800	102	as	as	IN
cord-001835-0s7ok4uw	3800	103	they	-PRON-	PRP
cord-001835-0s7ok4uw	3800	104	are	be	VBP
cord-001835-0s7ok4uw	3800	105	central	central	JJ
cord-001835-0s7ok4uw	3800	106	in	in	IN
cord-001835-0s7ok4uw	3800	107	the	the	DT
cord-001835-0s7ok4uw	3800	108	assembly	assembly	NN
cord-001835-0s7ok4uw	3800	109	and	and	CC
cord-001835-0s7ok4uw	3800	110	maturation	maturation	NN
cord-001835-0s7ok4uw	3800	111	of	of	IN
cord-001835-0s7ok4uw	3800	112	the	the	DT
cord-001835-0s7ok4uw	3800	113	chemical	chemical	JJ
cord-001835-0s7ok4uw	3800	114	synapses	synapsis	NNS
cord-001835-0s7ok4uw	3800	115	.	.	.
cord-001835-0s7ok4uw	3801	1	Several	several	JJ
cord-001835-0s7ok4uw	3801	2	families	family	NNS
cord-001835-0s7ok4uw	3801	3	of	of	IN
cord-001835-0s7ok4uw	3801	4	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	3801	5	adhesion	adhesion	NN
cord-001835-0s7ok4uw	3801	6	molecules	molecule	NNS
cord-001835-0s7ok4uw	3801	7	have	have	VBP
cord-001835-0s7ok4uw	3801	8	been	be	VBN
cord-001835-0s7ok4uw	3801	9	identified	identify	VBN
cord-001835-0s7ok4uw	3801	10	such	such	JJ
cord-001835-0s7ok4uw	3801	11	as	as	IN
cord-001835-0s7ok4uw	3801	12	NCAMs	ncam	NNS
cord-001835-0s7ok4uw	3801	13	,	,	,
cord-001835-0s7ok4uw	3801	14	neurexins	neurexin	NNS
cord-001835-0s7ok4uw	3801	15	and	and	CC
cord-001835-0s7ok4uw	3801	16	neuroligins	neuroligin	NNS
cord-001835-0s7ok4uw	3801	17	,	,	,
cord-001835-0s7ok4uw	3801	18	and	and	CC
cord-001835-0s7ok4uw	3801	19	in	in	IN
cord-001835-0s7ok4uw	3801	20	particular	particular	JJ
cord-001835-0s7ok4uw	3801	21	recently	recently	RB
cord-001835-0s7ok4uw	3801	22	several	several	JJ
cord-001835-0s7ok4uw	3801	23	leucine	leucine	NN
cord-001835-0s7ok4uw	3801	24	rich	rich	JJ
cord-001835-0s7ok4uw	3801	25	repeat	repeat	NN
cord-001835-0s7ok4uw	3801	26	protein	protein	NN
cord-001835-0s7ok4uw	3801	27	families	family	NNS
cord-001835-0s7ok4uw	3801	28	,	,	,
cord-001835-0s7ok4uw	3801	29	e.g.	e.g.	RB
cord-001835-0s7ok4uw	3801	30	Netrin	Netrin	NNP
cord-001835-0s7ok4uw	3801	31	G	G	NNP
cord-001835-0s7ok4uw	3801	32	-	-	HYPH
cord-001835-0s7ok4uw	3801	33	ligands	ligand	NNS
cord-001835-0s7ok4uw	3801	34	,	,	,
cord-001835-0s7ok4uw	3801	35	SLITRKs	slitrk	NNS
cord-001835-0s7ok4uw	3801	36	and	and	CC
cord-001835-0s7ok4uw	3801	37	LRRTMs	lrrtms	RB
cord-001835-0s7ok4uw	3801	38	.	.	.
cord-001835-0s7ok4uw	3802	1	The	the	DT
cord-001835-0s7ok4uw	3802	2	LRRTMs	lrrtm	NNS
cord-001835-0s7ok4uw	3802	3	form	form	VBP
cord-001835-0s7ok4uw	3802	4	a	a	DT
cord-001835-0s7ok4uw	3802	5	family	family	NN
cord-001835-0s7ok4uw	3802	6	of	of	IN
cord-001835-0s7ok4uw	3802	7	four	four	CD
cord-001835-0s7ok4uw	3802	8	proteins	protein	NNS
cord-001835-0s7ok4uw	3802	9	.	.	.
cord-001835-0s7ok4uw	3803	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	3803	2	have	have	VBP
cord-001835-0s7ok4uw	3803	3	been	be	VBN
cord-001835-0s7ok4uw	3803	4	implicated	implicate	VBN
cord-001835-0s7ok4uw	3803	5	in	in	IN
cord-001835-0s7ok4uw	3803	6	excitatory	excitatory	JJ
cord-001835-0s7ok4uw	3803	7	glutamatergic	glutamatergic	JJ
cord-001835-0s7ok4uw	3803	8	synapse	synapse	NN
cord-001835-0s7ok4uw	3803	9	function	function	NN
cord-001835-0s7ok4uw	3803	10	,	,	,
cord-001835-0s7ok4uw	3803	11	and	and	CC
cord-001835-0s7ok4uw	3803	12	were	be	VBD
cord-001835-0s7ok4uw	3803	13	specifically	specifically	RB
cord-001835-0s7ok4uw	3803	14	characterized	characterize	VBN
cord-001835-0s7ok4uw	3803	15	as	as	IN
cord-001835-0s7ok4uw	3803	16	ligands	ligand	NNS
cord-001835-0s7ok4uw	3803	17	for	for	IN
cord-001835-0s7ok4uw	3803	18	neurexins	neurexin	NNS
cord-001835-0s7ok4uw	3803	19	in	in	IN
cord-001835-0s7ok4uw	3803	20	excitatory	excitatory	JJ
cord-001835-0s7ok4uw	3803	21	synapse	synapse	NN
cord-001835-0s7ok4uw	3803	22	formation	formation	NN
cord-001835-0s7ok4uw	3803	23	and	and	CC
cord-001835-0s7ok4uw	3803	24	maintenance	maintenance	NN
cord-001835-0s7ok4uw	3803	25	.	.	.
cord-001835-0s7ok4uw	3804	1	In	in	IN
cord-001835-0s7ok4uw	3804	2	addition	addition	NN
cord-001835-0s7ok4uw	3804	3	,	,	,
cord-001835-0s7ok4uw	3804	4	LRRTM3	LRRTM3	NNP
cord-001835-0s7ok4uw	3804	5	and	and	CC
cord-001835-0s7ok4uw	3804	6	LRRTM4	LRRTM4	NNP
cord-001835-0s7ok4uw	3804	7	have	have	VBP
cord-001835-0s7ok4uw	3804	8	been	be	VBN
cord-001835-0s7ok4uw	3804	9	found	find	VBN
cord-001835-0s7ok4uw	3804	10	to	to	TO
cord-001835-0s7ok4uw	3804	11	be	be	VB
cord-001835-0s7ok4uw	3804	12	ligands	ligand	NNS
cord-001835-0s7ok4uw	3804	13	for	for	IN
cord-001835-0s7ok4uw	3804	14	heparan	heparan	JJ
cord-001835-0s7ok4uw	3804	15	sulphate	sulphate	NN
cord-001835-0s7ok4uw	3804	16	proteoglycans	proteoglycan	NNS
cord-001835-0s7ok4uw	3804	17	.	.	.
cord-001835-0s7ok4uw	3805	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3805	2	report	report	VBP
cord-001835-0s7ok4uw	3805	3	here	here	RB
cord-001835-0s7ok4uw	3805	4	the	the	DT
cord-001835-0s7ok4uw	3805	5	crystal	crystal	JJ
cord-001835-0s7ok4uw	3805	6	structure	structure	NN
cord-001835-0s7ok4uw	3805	7	of	of	IN
cord-001835-0s7ok4uw	3805	8	a	a	DT
cord-001835-0s7ok4uw	3805	9	stability	stability	NN
cord-001835-0s7ok4uw	3805	10	-	-	HYPH
cord-001835-0s7ok4uw	3805	11	engineered	engineer	VBN
cord-001835-0s7ok4uw	3805	12	mouse	mouse	NN
cord-001835-0s7ok4uw	3805	13	LRRTM2	LRRTM2	NNP
cord-001835-0s7ok4uw	3805	14	,	,	,
cord-001835-0s7ok4uw	3805	15	with	with	IN
cord-001835-0s7ok4uw	3805	16	a	a	DT
cord-001835-0s7ok4uw	3805	17	Tm	Tm	NNP
cord-001835-0s7ok4uw	3805	18	308C	308C	NNP
cord-001835-0s7ok4uw	3805	19	higher	high	JJR
cord-001835-0s7ok4uw	3805	20	than	than	IN
cord-001835-0s7ok4uw	3805	21	the	the	DT
cord-001835-0s7ok4uw	3805	22	wild	wild	JJ
cord-001835-0s7ok4uw	3805	23	type	type	NN
cord-001835-0s7ok4uw	3805	24	protein	protein	NN
cord-001835-0s7ok4uw	3805	25	,	,	,
cord-001835-0s7ok4uw	3805	26	while	while	IN
cord-001835-0s7ok4uw	3805	27	retaining	retain	VBG
cord-001835-0s7ok4uw	3805	28	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3805	29	function	function	NN
cord-001835-0s7ok4uw	3805	30	.	.	.
cord-001835-0s7ok4uw	3806	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3806	2	localized	localize	VBD
cord-001835-0s7ok4uw	3806	3	the	the	DT
cord-001835-0s7ok4uw	3806	4	neurexin	neurexin	JJ
cord-001835-0s7ok4uw	3806	5	binding	binding	NN
cord-001835-0s7ok4uw	3806	6	site	site	NN
cord-001835-0s7ok4uw	3806	7	to	to	IN
cord-001835-0s7ok4uw	3806	8	the	the	DT
cord-001835-0s7ok4uw	3806	9	concave	concave	JJ
cord-001835-0s7ok4uw	3806	10	surface	surface	NN
cord-001835-0s7ok4uw	3806	11	based	base	VBN
cord-001835-0s7ok4uw	3806	12	on	on	IN
cord-001835-0s7ok4uw	3806	13	protein	protein	NN
cord-001835-0s7ok4uw	3806	14	engineering	engineering	NN
cord-001835-0s7ok4uw	3806	15	,	,	,
cord-001835-0s7ok4uw	3806	16	sequence	sequence	NN
cord-001835-0s7ok4uw	3806	17	conservation	conservation	NN
cord-001835-0s7ok4uw	3806	18	and	and	CC
cord-001835-0s7ok4uw	3806	19	prior	prior	JJ
cord-001835-0s7ok4uw	3806	20	information	information	NN
cord-001835-0s7ok4uw	3806	21	on	on	IN
cord-001835-0s7ok4uw	3806	22	the	the	DT
cord-001835-0s7ok4uw	3806	23	ligand	ligand	NN
cord-001835-0s7ok4uw	3806	24	interaction	interaction	NN
cord-001835-0s7ok4uw	3806	25	with	with	IN
cord-001835-0s7ok4uw	3806	26	neurexins	neurexin	NNS
cord-001835-0s7ok4uw	3806	27	,	,	,
cord-001835-0s7ok4uw	3806	28	allowing	allow	VBG
cord-001835-0s7ok4uw	3806	29	us	-PRON-	PRP
cord-001835-0s7ok4uw	3806	30	to	to	TO
cord-001835-0s7ok4uw	3806	31	propose	propose	VB
cord-001835-0s7ok4uw	3806	32	a	a	DT
cord-001835-0s7ok4uw	3806	33	tentative	tentative	JJ
cord-001835-0s7ok4uw	3806	34	model	model	NN
cord-001835-0s7ok4uw	3806	35	for	for	IN
cord-001835-0s7ok4uw	3806	36	LRRTM	LRRTM	NNP
cord-001835-0s7ok4uw	3806	37	:	:	:
cord-001835-0s7ok4uw	3806	38	neurexin	neurexin	NNP
cord-001835-0s7ok4uw	3806	39	interaction	interaction	NNP
cord-001835-0s7ok4uw	3806	40	compex	compex	NNP
cord-001835-0s7ok4uw	3806	41	.	.	.
cord-001835-0s7ok4uw	3807	1	Cell	cell	NN
cord-001835-0s7ok4uw	3807	2	culture	culture	NN
cord-001835-0s7ok4uw	3807	3	studies	study	NNS
cord-001835-0s7ok4uw	3807	4	and	and	CC
cord-001835-0s7ok4uw	3807	5	binding	bind	VBG
cord-001835-0s7ok4uw	3807	6	experiments	experiment	NNS
cord-001835-0s7ok4uw	3807	7	show	show	VBP
cord-001835-0s7ok4uw	3807	8	that	that	IN
cord-001835-0s7ok4uw	3807	9	the	the	DT
cord-001835-0s7ok4uw	3807	10	engineered	engineer	VBN
cord-001835-0s7ok4uw	3807	11	protein	protein	NN
cord-001835-0s7ok4uw	3807	12	is	be	VBZ
cord-001835-0s7ok4uw	3807	13	functional	functional	JJ
cord-001835-0s7ok4uw	3807	14	and	and	CC
cord-001835-0s7ok4uw	3807	15	capable	capable	JJ
cord-001835-0s7ok4uw	3807	16	of	of	IN
cord-001835-0s7ok4uw	3807	17	forming	form	VBG
cord-001835-0s7ok4uw	3807	18	synapse	synapse	NN
cord-001835-0s7ok4uw	3807	19	-	-	HYPH
cord-001835-0s7ok4uw	3807	20	like	like	JJ
cord-001835-0s7ok4uw	3807	21	contacts	contact	NNS
cord-001835-0s7ok4uw	3807	22	.	.	.
cord-001835-0s7ok4uw	3808	1	Small	small	JJ
cord-001835-0s7ok4uw	3808	2	angle	angle	NN
cord-001835-0s7ok4uw	3808	3	X	x	NN
cord-001835-0s7ok4uw	3808	4	-	-	NN
cord-001835-0s7ok4uw	3808	5	ray	ray	NN
cord-001835-0s7ok4uw	3808	6	scattering	scattering	NN
cord-001835-0s7ok4uw	3808	7	data	datum	NNS
cord-001835-0s7ok4uw	3808	8	suggests	suggest	VBZ
cord-001835-0s7ok4uw	3808	9	that	that	IN
cord-001835-0s7ok4uw	3808	10	the	the	DT
cord-001835-0s7ok4uw	3808	11	wild	wild	JJ
cord-001835-0s7ok4uw	3808	12	type	type	NN
cord-001835-0s7ok4uw	3808	13	protein	protein	NN
cord-001835-0s7ok4uw	3808	14	forms	form	VBZ
cord-001835-0s7ok4uw	3808	15	transient	transient	JJ
cord-001835-0s7ok4uw	3808	16	dimers	dimer	NNS
cord-001835-0s7ok4uw	3808	17	,	,	,
cord-001835-0s7ok4uw	3808	18	which	which	WDT
cord-001835-0s7ok4uw	3808	19	may	may	MD
cord-001835-0s7ok4uw	3808	20	have	have	VB
cord-001835-0s7ok4uw	3808	21	importance	importance	NN
cord-001835-0s7ok4uw	3808	22	for	for	IN
cord-001835-0s7ok4uw	3808	23	the	the	DT
cord-001835-0s7ok4uw	3808	24	function	function	NN
cord-001835-0s7ok4uw	3808	25	.	.	.
cord-001835-0s7ok4uw	3809	1	The	the	DT
cord-001835-0s7ok4uw	3809	2	structural	structural	JJ
cord-001835-0s7ok4uw	3809	3	and	and	CC
cord-001835-0s7ok4uw	3809	4	functional	functional	JJ
cord-001835-0s7ok4uw	3809	5	data	datum	NNS
cord-001835-0s7ok4uw	3809	6	presented	present	VBN
cord-001835-0s7ok4uw	3809	7	here	here	RB
cord-001835-0s7ok4uw	3809	8	provide	provide	VB
cord-001835-0s7ok4uw	3809	9	the	the	DT
cord-001835-0s7ok4uw	3809	10	first	first	JJ
cord-001835-0s7ok4uw	3809	11	structure	structure	NN
cord-001835-0s7ok4uw	3809	12	of	of	IN
cord-001835-0s7ok4uw	3809	13	an	an	DT
cord-001835-0s7ok4uw	3809	14	LRRTM	LRRTM	NNP
cord-001835-0s7ok4uw	3809	15	protein	protein	NN
cord-001835-0s7ok4uw	3809	16	,	,	,
cord-001835-0s7ok4uw	3809	17	and	and	CC
cord-001835-0s7ok4uw	3809	18	a	a	DT
cord-001835-0s7ok4uw	3809	19	model	model	NN
cord-001835-0s7ok4uw	3809	20	for	for	IN
cord-001835-0s7ok4uw	3809	21	molecular	molecular	JJ
cord-001835-0s7ok4uw	3809	22	mechanism	mechanism	NN
cord-001835-0s7ok4uw	3809	23	of	of	IN
cord-001835-0s7ok4uw	3809	24	LRRTM	LRRTM	NNP
cord-001835-0s7ok4uw	3809	25	function	function	NN
cord-001835-0s7ok4uw	3809	26	in	in	IN
cord-001835-0s7ok4uw	3809	27	adhesion	adhesion	NN
cord-001835-0s7ok4uw	3809	28	.	.	.
cord-001835-0s7ok4uw	3810	1	Computational	computational	JJ
cord-001835-0s7ok4uw	3810	2	design	design	NN
cord-001835-0s7ok4uw	3810	3	of	of	IN
cord-001835-0s7ok4uw	3810	4	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	3810	5	binder	binder	NN
cord-001835-0s7ok4uw	3810	6	Olga	Olga	NNP
cord-001835-0s7ok4uw	3810	7	Khersonsky	Khersonsky	NNP
cord-001835-0s7ok4uw	3810	8	1	1	CD
cord-001835-0s7ok4uw	3810	9	,	,	,
cord-001835-0s7ok4uw	3810	10	Gil	Gil	NNP
cord-001835-0s7ok4uw	3810	11	Benezer	Benezer	NNP
cord-001835-0s7ok4uw	3810	12	1	1	CD
cord-001835-0s7ok4uw	3811	1	,	,	,
cord-001835-0s7ok4uw	3811	2	Sarel	Sarel	NNP
cord-001835-0s7ok4uw	3811	3	Fleishman	Fleishman	NNP
cord-001835-0s7ok4uw	3811	4	1	1	CD
cord-001835-0s7ok4uw	3811	5	1	1	CD
cord-001835-0s7ok4uw	3811	6	Recently	recently	RB
cord-001835-0s7ok4uw	3811	7	,	,	,
cord-001835-0s7ok4uw	3811	8	AbDesign	AbDesign	NNP
cord-001835-0s7ok4uw	3811	9	algorithm	algorithm	NN
cord-001835-0s7ok4uw	3811	10	was	be	VBD
cord-001835-0s7ok4uw	3811	11	developed	develop	VBN
cord-001835-0s7ok4uw	3811	12	in	in	IN
cord-001835-0s7ok4uw	3811	13	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3811	14	lab	lab	NN
cord-001835-0s7ok4uw	3811	15	for	for	IN
cord-001835-0s7ok4uw	3811	16	de	de	FW
cord-001835-0s7ok4uw	3811	17	novo	novo	NN
cord-001835-0s7ok4uw	3811	18	design	design	NN
cord-001835-0s7ok4uw	3811	19	of	of	IN
cord-001835-0s7ok4uw	3811	20	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3811	21	(	(	-LRB-
cord-001835-0s7ok4uw	3811	22	1	1	CD
cord-001835-0s7ok4uw	3811	23	)	)	-RRB-
cord-001835-0s7ok4uw	3811	24	.	.	.
cord-001835-0s7ok4uw	3812	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3812	2	is	be	VBZ
cord-001835-0s7ok4uw	3812	3	guided	guide	VBN
cord-001835-0s7ok4uw	3812	4	by	by	IN
cord-001835-0s7ok4uw	3812	5	natural	natural	JJ
cord-001835-0s7ok4uw	3812	6	conformations	conformation	NNS
cord-001835-0s7ok4uw	3812	7	and	and	CC
cord-001835-0s7ok4uw	3812	8	sequences	sequence	NNS
cord-001835-0s7ok4uw	3812	9	,	,	,
cord-001835-0s7ok4uw	3812	10	and	and	CC
cord-001835-0s7ok4uw	3812	11	exploits	exploit	VBZ
cord-001835-0s7ok4uw	3812	12	the	the	DT
cord-001835-0s7ok4uw	3812	13	modular	modular	JJ
cord-001835-0s7ok4uw	3812	14	nature	nature	NN
cord-001835-0s7ok4uw	3812	15	of	of	IN
cord-001835-0s7ok4uw	3812	16	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3812	17	to	to	IN
cord-001835-0s7ok4uw	3812	18	ABSTRACT	ABSTRACT	NNP
cord-001835-0s7ok4uw	3812	19	generate	generate	VBP
cord-001835-0s7ok4uw	3812	20	an	an	DT
cord-001835-0s7ok4uw	3812	21	immense	immense	JJ
cord-001835-0s7ok4uw	3812	22	space	space	NN
cord-001835-0s7ok4uw	3812	23	of	of	IN
cord-001835-0s7ok4uw	3812	24	conformations	conformation	NNS
cord-001835-0s7ok4uw	3812	25	,	,	,
cord-001835-0s7ok4uw	3812	26	which	which	WDT
cord-001835-0s7ok4uw	3812	27	can	can	MD
cord-001835-0s7ok4uw	3812	28	be	be	VB
cord-001835-0s7ok4uw	3812	29	used	use	VBN
cord-001835-0s7ok4uw	3812	30	as	as	IN
cord-001835-0s7ok4uw	3812	31	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3812	32	for	for	IN
cord-001835-0s7ok4uw	3812	33	design	design	NN
cord-001835-0s7ok4uw	3812	34	of	of	IN
cord-001835-0s7ok4uw	3812	35	stable	stable	JJ
cord-001835-0s7ok4uw	3812	36	highaffinity	highaffinity	NN
cord-001835-0s7ok4uw	3812	37	binders	binder	NNS
cord-001835-0s7ok4uw	3812	38	.	.	.
cord-001835-0s7ok4uw	3813	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3813	2	have	have	VBP
cord-001835-0s7ok4uw	3813	3	used	use	VBN
cord-001835-0s7ok4uw	3813	4	AbDesign	AbDesign	NNP
cord-001835-0s7ok4uw	3813	5	to	to	TO
cord-001835-0s7ok4uw	3813	6	design	design	VB
cord-001835-0s7ok4uw	3813	7	a	a	DT
cord-001835-0s7ok4uw	3813	8	binder	binder	NN
cord-001835-0s7ok4uw	3813	9	of	of	IN
cord-001835-0s7ok4uw	3813	10	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	3813	11	.	.	.
cord-001835-0s7ok4uw	3814	1	30,000	30,000	CD
cord-001835-0s7ok4uw	3814	2	antibody	antibody	NN
cord-001835-0s7ok4uw	3814	3	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3814	4	were	be	VBD
cord-001835-0s7ok4uw	3814	5	obtained	obtain	VBN
cord-001835-0s7ok4uw	3814	6	by	by	IN
cord-001835-0s7ok4uw	3814	7	splicing	splice	VBG
cord-001835-0s7ok4uw	3814	8	H3	H3	NNP
cord-001835-0s7ok4uw	3814	9	and	and	CC
cord-001835-0s7ok4uw	3814	10	L3	L3	NNP
cord-001835-0s7ok4uw	3814	11	fragments	fragment	NNS
cord-001835-0s7ok4uw	3814	12	into	into	IN
cord-001835-0s7ok4uw	3814	13	a	a	DT
cord-001835-0s7ok4uw	3814	14	template	template	NN
cord-001835-0s7ok4uw	3814	15	(	(	-LRB-
cord-001835-0s7ok4uw	3814	16	pdb	pdb	NN
cord-001835-0s7ok4uw	3814	17	ID	ID	NNP
cord-001835-0s7ok4uw	3814	18	2brr	2brr	CD
cord-001835-0s7ok4uw	3814	19	)	)	-RRB-
cord-001835-0s7ok4uw	3814	20	,	,	,
cord-001835-0s7ok4uw	3814	21	and	and	CC
cord-001835-0s7ok4uw	3814	22	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	3814	23	optimization	optimization	NN
cord-001835-0s7ok4uw	3814	24	of	of	IN
cord-001835-0s7ok4uw	3814	25	VH	VH	NNP
cord-001835-0s7ok4uw	3814	26	and	and	CC
cord-001835-0s7ok4uw	3814	27	VL	VL	NNP
cord-001835-0s7ok4uw	3814	28	orientation	orientation	NN
cord-001835-0s7ok4uw	3814	29	.	.	.
cord-001835-0s7ok4uw	3815	1	Phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	3815	2	binding	binding	NN
cord-001835-0s7ok4uw	3815	3	site	site	NN
cord-001835-0s7ok4uw	3815	4	,	,	,
cord-001835-0s7ok4uw	3815	5	based	base	VBN
cord-001835-0s7ok4uw	3815	6	on	on	IN
cord-001835-0s7ok4uw	3815	7	native	native	JJ
cord-001835-0s7ok4uw	3815	8	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	3815	9	binders	binder	NNS
cord-001835-0s7ok4uw	3815	10	,	,	,
cord-001835-0s7ok4uw	3815	11	was	be	VBD
cord-001835-0s7ok4uw	3815	12	introduced	introduce	VBN
cord-001835-0s7ok4uw	3815	13	into	into	IN
cord-001835-0s7ok4uw	3815	14	the	the	DT
cord-001835-0s7ok4uw	3815	15	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3815	16	with	with	IN
cord-001835-0s7ok4uw	3815	17	RosettaMatch	RosettaMatch	NNP
cord-001835-0s7ok4uw	3815	18	(	(	-LRB-
cord-001835-0s7ok4uw	3815	19	2	2	CD
cord-001835-0s7ok4uw	3815	20	)	)	-RRB-
cord-001835-0s7ok4uw	3815	21	,	,	,
cord-001835-0s7ok4uw	3815	22	and	and	CC
cord-001835-0s7ok4uw	3815	23	the	the	DT
cord-001835-0s7ok4uw	3815	24	sequences	sequence	NNS
cord-001835-0s7ok4uw	3815	25	were	be	VBD
cord-001835-0s7ok4uw	3815	26	subsequently	subsequently	RB
cord-001835-0s7ok4uw	3815	27	optimized	optimize	VBN
cord-001835-0s7ok4uw	3815	28	by	by	IN
cord-001835-0s7ok4uw	3815	29	Rosetta	Rosetta	NNP
cord-001835-0s7ok4uw	3815	30	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3815	31	design	design	NN
cord-001835-0s7ok4uw	3815	32	protocol	protocol	NN
cord-001835-0s7ok4uw	3815	33	(	(	-LRB-
cord-001835-0s7ok4uw	3815	34	3	3	CD
cord-001835-0s7ok4uw	3815	35	)	)	-RRB-
cord-001835-0s7ok4uw	3815	36	.	.	.
cord-001835-0s7ok4uw	3816	1	30	30	CD
cord-001835-0s7ok4uw	3816	2	designs	design	NNS
cord-001835-0s7ok4uw	3816	3	were	be	VBD
cord-001835-0s7ok4uw	3816	4	experimentally	experimentally	RB
cord-001835-0s7ok4uw	3816	5	tested	test	VBN
cord-001835-0s7ok4uw	3816	6	by	by	IN
cord-001835-0s7ok4uw	3816	7	yeast	yeast	NN
cord-001835-0s7ok4uw	3816	8	display	display	NN
cord-001835-0s7ok4uw	3816	9	for	for	IN
cord-001835-0s7ok4uw	3816	10	binding	bind	VBG
cord-001835-0s7ok4uw	3816	11	of	of	IN
cord-001835-0s7ok4uw	3816	12	biotinylated	biotinylated	JJ
cord-001835-0s7ok4uw	3816	13	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	3816	14	ligand	ligand	NN
cord-001835-0s7ok4uw	3816	15	.	.	.
cord-001835-0s7ok4uw	3817	1	Several	several	JJ
cord-001835-0s7ok4uw	3817	2	designs	design	NNS
cord-001835-0s7ok4uw	3817	3	were	be	VBD
cord-001835-0s7ok4uw	3817	4	found	find	VBN
cord-001835-0s7ok4uw	3817	5	to	to	TO
cord-001835-0s7ok4uw	3817	6	bind	bind	VB
cord-001835-0s7ok4uw	3817	7	the	the	DT
cord-001835-0s7ok4uw	3817	8	ligand	ligand	NN
cord-001835-0s7ok4uw	3817	9	,	,	,
cord-001835-0s7ok4uw	3817	10	and	and	CC
cord-001835-0s7ok4uw	3817	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	3817	12	plan	plan	VBP
cord-001835-0s7ok4uw	3817	13	to	to	TO
cord-001835-0s7ok4uw	3817	14	further	further	RB
cord-001835-0s7ok4uw	3817	15	characterize	characterize	VB
cord-001835-0s7ok4uw	3817	16	this	this	DT
cord-001835-0s7ok4uw	3817	17	affinity	affinity	NN
cord-001835-0s7ok4uw	3817	18	and	and	CC
cord-001835-0s7ok4uw	3817	19	improve	improve	VB
cord-001835-0s7ok4uw	3817	20	it	-PRON-	PRP
cord-001835-0s7ok4uw	3817	21	using	use	VBG
cord-001835-0s7ok4uw	3817	22	directed	direct	VBN
cord-001835-0s7ok4uw	3817	23	evolution	evolution	NN
cord-001835-0s7ok4uw	3817	24	techniques	technique	NNS
cord-001835-0s7ok4uw	3817	25	.	.	.
cord-001835-0s7ok4uw	3818	1	In	in	IN
cord-001835-0s7ok4uw	3818	2	collaboration	collaboration	NN
cord-001835-0s7ok4uw	3818	3	with	with	IN
cord-001835-0s7ok4uw	3818	4	the	the	DT
cord-001835-0s7ok4uw	3818	5	group	group	NN
cord-001835-0s7ok4uw	3818	6	of	of	IN
cord-001835-0s7ok4uw	3818	7	Prof.	Prof.	NNP
cord-001835-0s7ok4uw	3818	8	Johnsonn	Johnsonn	NNP
cord-001835-0s7ok4uw	3818	9	,	,	,
cord-001835-0s7ok4uw	3818	10	the	the	DT
cord-001835-0s7ok4uw	3818	11	resulting	result	VBG
cord-001835-0s7ok4uw	3818	12	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	3818	13	binder	binder	NN
cord-001835-0s7ok4uw	3818	14	will	will	MD
cord-001835-0s7ok4uw	3818	15	be	be	VB
cord-001835-0s7ok4uw	3818	16	incorporated	incorporate	VBN
cord-001835-0s7ok4uw	3818	17	in	in	IN
cord-001835-0s7ok4uw	3818	18	a	a	DT
cord-001835-0s7ok4uw	3818	19	bio	bio	JJ
cord-001835-0s7ok4uw	3818	20	-	-	JJ
cord-001835-0s7ok4uw	3818	21	luminescent	luminescent	JJ
cord-001835-0s7ok4uw	3818	22	(	(	-LRB-
cord-001835-0s7ok4uw	3818	23	LUCID	LUCID	NNP
cord-001835-0s7ok4uw	3818	24	)	)	-RRB-
cord-001835-0s7ok4uw	3818	25	sensor	sensor	NN
cord-001835-0s7ok4uw	3818	26	for	for	IN
cord-001835-0s7ok4uw	3818	27	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	3818	28	(	(	-LRB-
cord-001835-0s7ok4uw	3818	29	4	4	CD
cord-001835-0s7ok4uw	3818	30	)	)	-RRB-
cord-001835-0s7ok4uw	3818	31	.	.	.
cord-001835-0s7ok4uw	3819	1	Phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	3819	2	monitoring	monitoring	NN
cord-001835-0s7ok4uw	3819	3	device	device	NN
cord-001835-0s7ok4uw	3819	4	would	would	MD
cord-001835-0s7ok4uw	3819	5	be	be	VB
cord-001835-0s7ok4uw	3819	6	of	of	IN
cord-001835-0s7ok4uw	3819	7	primary	primary	JJ
cord-001835-0s7ok4uw	3819	8	importance	importance	NN
cord-001835-0s7ok4uw	3819	9	for	for	IN
cord-001835-0s7ok4uw	3819	10	patients	patient	NNS
cord-001835-0s7ok4uw	3819	11	with	with	IN
cord-001835-0s7ok4uw	3819	12	phenylketonuria	phenylketonuria	NN
cord-001835-0s7ok4uw	3819	13	,	,	,
cord-001835-0s7ok4uw	3819	14	a	a	DT
cord-001835-0s7ok4uw	3819	15	genetic	genetic	JJ
cord-001835-0s7ok4uw	3819	16	disease	disease	NN
cord-001835-0s7ok4uw	3819	17	with	with	IN
cord-001835-0s7ok4uw	3819	18	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	3819	19	metabolism	metabolism	NN
cord-001835-0s7ok4uw	3819	20	problem	problem	NN
cord-001835-0s7ok4uw	3819	21	.	.	.
cord-001835-0s7ok4uw	3820	1	Cold	Cold	NNP
cord-001835-0s7ok4uw	3820	2	-	-	HYPH
cord-001835-0s7ok4uw	3820	3	adapted	adapt	VBN
cord-001835-0s7ok4uw	3820	4	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3820	5	are	be	VBP
cord-001835-0s7ok4uw	3820	6	interesting	interesting	JJ
cord-001835-0s7ok4uw	3820	7	because	because	IN
cord-001835-0s7ok4uw	3820	8	of	of	IN
cord-001835-0s7ok4uw	3820	9	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3820	10	higher	high	JJR
cord-001835-0s7ok4uw	3820	11	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3820	12	activity	activity	NN
cord-001835-0s7ok4uw	3820	13	compared	compare	VBN
cord-001835-0s7ok4uw	3820	14	to	to	IN
cord-001835-0s7ok4uw	3820	15	mesophilic	mesophilic	JJ
cord-001835-0s7ok4uw	3820	16	and	and	CC
cord-001835-0s7ok4uw	3820	17	thermophilic	thermophilic	JJ
cord-001835-0s7ok4uw	3820	18	homologues	homologue	NNS
cord-001835-0s7ok4uw	3820	19	.	.	.
cord-001835-0s7ok4uw	3821	1	Alkaline	alkaline	JJ
cord-001835-0s7ok4uw	3821	2	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	3821	3	(	(	-LRB-
cord-001835-0s7ok4uw	3821	4	AP	AP	NNP
cord-001835-0s7ok4uw	3821	5	)	)	-RRB-
cord-001835-0s7ok4uw	3821	6	from	from	IN
cord-001835-0s7ok4uw	3821	7	a	a	DT
cord-001835-0s7ok4uw	3821	8	psychrophilic	psychrophilic	NN
cord-001835-0s7ok4uw	3821	9	Vibrio	Vibrio	NNP
cord-001835-0s7ok4uw	3821	10	marine	marine	JJ
cord-001835-0s7ok4uw	3821	11	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	3821	12	(	(	-LRB-
cord-001835-0s7ok4uw	3821	13	VAP	VAP	NNP
cord-001835-0s7ok4uw	3821	14	)	)	-RRB-
cord-001835-0s7ok4uw	3821	15	has	have	VBZ
cord-001835-0s7ok4uw	3821	16	an	an	DT
cord-001835-0s7ok4uw	3821	17	unusual	unusual	JJ
cord-001835-0s7ok4uw	3821	18	large	large	JJ
cord-001835-0s7ok4uw	3821	19	surface	surface	NN
cord-001835-0s7ok4uw	3821	20	loop	loop	NN
cord-001835-0s7ok4uw	3821	21	that	that	WDT
cord-001835-0s7ok4uw	3821	22	extends	extend	VBZ
cord-001835-0s7ok4uw	3821	23	from	from	IN
cord-001835-0s7ok4uw	3821	24	each	each	DT
cord-001835-0s7ok4uw	3821	25	of	of	IN
cord-001835-0s7ok4uw	3821	26	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3821	27	monomers	monomer	NNS
cord-001835-0s7ok4uw	3821	28	to	to	TO
cord-001835-0s7ok4uw	3821	29	stabilize	stabilize	VB
cord-001835-0s7ok4uw	3821	30	a	a	DT
cord-001835-0s7ok4uw	3821	31	homodimeric	homodimeric	JJ
cord-001835-0s7ok4uw	3821	32	structure	structure	NN
cord-001835-0s7ok4uw	3821	33	(	(	-LRB-
cord-001835-0s7ok4uw	3821	34	1	1	CD
cord-001835-0s7ok4uw	3821	35	)	)	-RRB-
cord-001835-0s7ok4uw	3821	36	.	.	.
cord-001835-0s7ok4uw	3822	1	In	in	IN
cord-001835-0s7ok4uw	3822	2	many	many	JJ
cord-001835-0s7ok4uw	3822	3	cold	cold	NN
cord-001835-0s7ok4uw	3822	4	-	-	HYPH
cord-001835-0s7ok4uw	3822	5	adapted	adapt	VBN
cord-001835-0s7ok4uw	3822	6	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3822	7	,	,	,
cord-001835-0s7ok4uw	3822	8	the	the	DT
cord-001835-0s7ok4uw	3822	9	loop	loop	NN
cord-001835-0s7ok4uw	3822	10	regions	region	NNS
cord-001835-0s7ok4uw	3822	11	are	be	VBP
cord-001835-0s7ok4uw	3822	12	longer	long	RBR
cord-001835-0s7ok4uw	3822	13	compared	compare	VBN
cord-001835-0s7ok4uw	3822	14	to	to	IN
cord-001835-0s7ok4uw	3822	15	proteins	protein	NNS
cord-001835-0s7ok4uw	3822	16	of	of	IN
cord-001835-0s7ok4uw	3822	17	mesophilic	mesophilic	JJ
cord-001835-0s7ok4uw	3822	18	organisms	organism	NNS
cord-001835-0s7ok4uw	3822	19	and	and	CC
cord-001835-0s7ok4uw	3822	20	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3822	21	aim	aim	NN
cord-001835-0s7ok4uw	3822	22	was	be	VBD
cord-001835-0s7ok4uw	3822	23	to	to	TO
cord-001835-0s7ok4uw	3822	24	study	study	VB
cord-001835-0s7ok4uw	3822	25	the	the	DT
cord-001835-0s7ok4uw	3822	26	functional	functional	JJ
cord-001835-0s7ok4uw	3822	27	and	and	CC
cord-001835-0s7ok4uw	3822	28	structural	structural	JJ
cord-001835-0s7ok4uw	3822	29	role	role	NN
cord-001835-0s7ok4uw	3822	30	of	of	IN
cord-001835-0s7ok4uw	3822	31	this	this	DT
cord-001835-0s7ok4uw	3822	32	loop	loop	NN
cord-001835-0s7ok4uw	3822	33	.	.	.
cord-001835-0s7ok4uw	3823	1	Three	three	CD
cord-001835-0s7ok4uw	3823	2	substitutions	substitution	NNS
cord-001835-0s7ok4uw	3823	3	(	(	-LRB-
cord-001835-0s7ok4uw	3823	4	R336L	R336L	NNP
cord-001835-0s7ok4uw	3823	5	,	,	,
cord-001835-0s7ok4uw	3823	6	Y346F	Y346F	NNP
cord-001835-0s7ok4uw	3823	7	and	and	CC
cord-001835-0s7ok4uw	3823	8	F355Y	F355Y	NNP
cord-001835-0s7ok4uw	3823	9	)	)	-RRB-
cord-001835-0s7ok4uw	3823	10	were	be	VBD
cord-001835-0s7ok4uw	3823	11	introduced	introduce	VBN
cord-001835-0s7ok4uw	3823	12	within	within	IN
cord-001835-0s7ok4uw	3823	13	the	the	DT
cord-001835-0s7ok4uw	3823	14	large	large	JJ
cord-001835-0s7ok4uw	3823	15	surface	surface	NN
cord-001835-0s7ok4uw	3823	16	loop	loop	NN
cord-001835-0s7ok4uw	3823	17	as	as	IN
cord-001835-0s7ok4uw	3823	18	directed	direct	VBN
cord-001835-0s7ok4uw	3823	19	by	by	IN
cord-001835-0s7ok4uw	3823	20	1microsecond	1microsecond	CD
cord-001835-0s7ok4uw	3823	21	molecular	molecular	JJ
cord-001835-0s7ok4uw	3823	22	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3823	23	(	(	-LRB-
cord-001835-0s7ok4uw	3823	24	MD	MD	NNP
cord-001835-0s7ok4uw	3823	25	)	)	-RRB-
cord-001835-0s7ok4uw	3823	26	simulations	simulation	NNS
cord-001835-0s7ok4uw	3823	27	.	.	.
cord-001835-0s7ok4uw	3824	1	With	with	IN
cord-001835-0s7ok4uw	3824	2	the	the	DT
cord-001835-0s7ok4uw	3824	3	R336L	R336L	NNP
cord-001835-0s7ok4uw	3824	4	mutation	mutation	NN
cord-001835-0s7ok4uw	3824	5	,	,	,
cord-001835-0s7ok4uw	3824	6	two	two	CD
cord-001835-0s7ok4uw	3824	7	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3824	8	bonds	bond	NNS
cord-001835-0s7ok4uw	3824	9	were	be	VBD
cord-001835-0s7ok4uw	3824	10	broken	break	VBN
cord-001835-0s7ok4uw	3824	11	that	that	WDT
cord-001835-0s7ok4uw	3824	12	connect	connect	VBP
cord-001835-0s7ok4uw	3824	13	the	the	DT
cord-001835-0s7ok4uw	3824	14	loop	loop	NN
cord-001835-0s7ok4uw	3824	15	to	to	IN
cord-001835-0s7ok4uw	3824	16	residues	residue	NNS
cord-001835-0s7ok4uw	3824	17	on	on	IN
cord-001835-0s7ok4uw	3824	18	the	the	DT
cord-001835-0s7ok4uw	3824	19	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	3824	20	subunit	subunit	NN
cord-001835-0s7ok4uw	3824	21	,	,	,
cord-001835-0s7ok4uw	3824	22	and	and	CC
cord-001835-0s7ok4uw	3824	23	further	further	JJ
cord-001835-0s7ok4uw	3824	24	two	two	CD
cord-001835-0s7ok4uw	3824	25	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3824	26	bonds	bond	NNS
cord-001835-0s7ok4uw	3824	27	broken	break	VBN
cord-001835-0s7ok4uw	3824	28	with	with	IN
cord-001835-0s7ok4uw	3824	29	the	the	DT
cord-001835-0s7ok4uw	3824	30	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	3824	31	Q334	Q334	NNP
cord-001835-0s7ok4uw	3824	32	.	.	.
cord-001835-0s7ok4uw	3825	1	As	as	IN
cord-001835-0s7ok4uw	3825	2	a	a	DT
cord-001835-0s7ok4uw	3825	3	consequence	consequence	NN
cord-001835-0s7ok4uw	3825	4	,	,	,
cord-001835-0s7ok4uw	3825	5	R336L	R336L	NNP
cord-001835-0s7ok4uw	3825	6	displayed	display	VBD
cord-001835-0s7ok4uw	3825	7	a	a	DT
cord-001835-0s7ok4uw	3825	8	25	25	CD
cord-001835-0s7ok4uw	3825	9	%	%	NN
cord-001835-0s7ok4uw	3825	10	higher	high	JJR
cord-001835-0s7ok4uw	3825	11	kcat	kcat	NNP
cord-001835-0s7ok4uw	3825	12	compared	compare	VBN
cord-001835-0s7ok4uw	3825	13	with	with	IN
cord-001835-0s7ok4uw	3825	14	wild	wild	JJ
cord-001835-0s7ok4uw	3825	15	-	-	HYPH
cord-001835-0s7ok4uw	3825	16	type	type	NN
cord-001835-0s7ok4uw	3825	17	and	and	CC
cord-001835-0s7ok4uw	3825	18	a	a	DT
cord-001835-0s7ok4uw	3825	19	slight	slight	JJ
cord-001835-0s7ok4uw	3825	20	decrease	decrease	NN
cord-001835-0s7ok4uw	3825	21	in	in	IN
cord-001835-0s7ok4uw	3825	22	the	the	DT
cord-001835-0s7ok4uw	3825	23	Km	Km	NNP
cord-001835-0s7ok4uw	3825	24	value	value	NN
cord-001835-0s7ok4uw	3825	25	.	.	.
cord-001835-0s7ok4uw	3826	1	Overall	overall	RB
cord-001835-0s7ok4uw	3826	2	,	,	,
cord-001835-0s7ok4uw	3826	3	the	the	DT
cord-001835-0s7ok4uw	3826	4	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3826	5	efficient	efficient	JJ
cord-001835-0s7ok4uw	3826	6	improved	improve	VBN
cord-001835-0s7ok4uw	3826	7	by	by	IN
cord-001835-0s7ok4uw	3826	8	45	45	CD
cord-001835-0s7ok4uw	3826	9	%	%	NN
cord-001835-0s7ok4uw	3826	10	.	.	.
cord-001835-0s7ok4uw	3827	1	The	the	DT
cord-001835-0s7ok4uw	3827	2	global	global	JJ
cord-001835-0s7ok4uw	3827	3	heat	heat	NN
cord-001835-0s7ok4uw	3827	4	stability	stability	NN
cord-001835-0s7ok4uw	3827	5	(	(	-LRB-
cord-001835-0s7ok4uw	3827	6	Tm	Tm	NNP
cord-001835-0s7ok4uw	3827	7	)	)	-RRB-
cord-001835-0s7ok4uw	3827	8	and	and	CC
cord-001835-0s7ok4uw	3827	9	the	the	DT
cord-001835-0s7ok4uw	3827	10	active	active	JJ
cord-001835-0s7ok4uw	3827	11	site	site	NN
cord-001835-0s7ok4uw	3827	12	sensitivity	sensitivity	NN
cord-001835-0s7ok4uw	3827	13	to	to	IN
cord-001835-0s7ok4uw	3827	14	heat	heat	NN
cord-001835-0s7ok4uw	3827	15	(	(	-LRB-
cord-001835-0s7ok4uw	3827	16	T50	T50	NNP
cord-001835-0s7ok4uw	3827	17	%	%	NN
cord-001835-0s7ok4uw	3827	18	)	)	-RRB-
cord-001835-0s7ok4uw	3827	19	were	be	VBD
cord-001835-0s7ok4uw	3827	20	reduced	reduce	VBN
cord-001835-0s7ok4uw	3827	21	by	by	IN
cord-001835-0s7ok4uw	3827	22	68C	68c	NN
cord-001835-0s7ok4uw	3827	23	and	and	CC
cord-001835-0s7ok4uw	3827	24	138C	138c	CD
cord-001835-0s7ok4uw	3827	25	,	,	,
cord-001835-0s7ok4uw	3827	26	respectively	respectively	RB
cord-001835-0s7ok4uw	3827	27	.	.	.
cord-001835-0s7ok4uw	3828	1	MD	MD	NNP
cord-001835-0s7ok4uw	3828	2	simulations	simulation	NNS
cord-001835-0s7ok4uw	3828	3	showed	show	VBD
cord-001835-0s7ok4uw	3828	4	that	that	IN
cord-001835-0s7ok4uw	3828	5	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3828	6	bonds	bond	NNS
cord-001835-0s7ok4uw	3828	7	to	to	IN
cord-001835-0s7ok4uw	3828	8	Arg336	Arg336	,
cord-001835-0s7ok4uw	3828	9	are	be	VBP
cord-001835-0s7ok4uw	3828	10	important	important	JJ
cord-001835-0s7ok4uw	3828	11	for	for	IN
cord-001835-0s7ok4uw	3828	12	longrange	longrange	JJ
cord-001835-0s7ok4uw	3828	13	communication	communication	NN
cord-001835-0s7ok4uw	3828	14	to	to	IN
cord-001835-0s7ok4uw	3828	15	the	the	DT
cord-001835-0s7ok4uw	3828	16	active	active	JJ
cord-001835-0s7ok4uw	3828	17	site	site	NN
cord-001835-0s7ok4uw	3828	18	.	.	.
cord-001835-0s7ok4uw	3829	1	Certain	certain	JJ
cord-001835-0s7ok4uw	3829	2	rotamers	rotamer	NNS
cord-001835-0s7ok4uw	3829	3	of	of	IN
cord-001835-0s7ok4uw	3829	4	two	two	CD
cord-001835-0s7ok4uw	3829	5	important	important	JJ
cord-001835-0s7ok4uw	3829	6	residues	residue	NNS
cord-001835-0s7ok4uw	3829	7	in	in	IN
cord-001835-0s7ok4uw	3829	8	the	the	DT
cord-001835-0s7ok4uw	3829	9	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3829	10	site	site	NN
cord-001835-0s7ok4uw	3829	11	,	,	,
cord-001835-0s7ok4uw	3829	12	Ser65	Ser65	NNP
cord-001835-0s7ok4uw	3829	13	and	and	CC
cord-001835-0s7ok4uw	3829	14	Arg129	Arg129	NNS
cord-001835-0s7ok4uw	3829	15	,	,	,
cord-001835-0s7ok4uw	3829	16	were	be	VBD
cord-001835-0s7ok4uw	3829	17	favored	favor	VBN
cord-001835-0s7ok4uw	3829	18	,	,	,
cord-001835-0s7ok4uw	3829	19	presumably	presumably	RB
cord-001835-0s7ok4uw	3829	20	toward	toward	IN
cord-001835-0s7ok4uw	3829	21	states	state	NNS
cord-001835-0s7ok4uw	3829	22	more	more	RBR
cord-001835-0s7ok4uw	3829	23	competent	competent	JJ
cord-001835-0s7ok4uw	3829	24	for	for	IN
cord-001835-0s7ok4uw	3829	25	catalysis	catalysis	NN
cord-001835-0s7ok4uw	3829	26	upon	upon	IN
cord-001835-0s7ok4uw	3829	27	the	the	DT
cord-001835-0s7ok4uw	3829	28	replacement	replacement	NN
cord-001835-0s7ok4uw	3829	29	of	of	IN
cord-001835-0s7ok4uw	3829	30	Arg336	arg336	DT
cord-001835-0s7ok4uw	3829	31	with	with	IN
cord-001835-0s7ok4uw	3829	32	Leu	Leu	NNP
cord-001835-0s7ok4uw	3829	33	.	.	.
cord-001835-0s7ok4uw	3830	1	In	in	IN
cord-001835-0s7ok4uw	3830	2	the	the	DT
cord-001835-0s7ok4uw	3830	3	Y346F	Y346F	NNP
cord-001835-0s7ok4uw	3830	4	variant	variant	NN
cord-001835-0s7ok4uw	3830	5	,	,	,
cord-001835-0s7ok4uw	3830	6	removal	removal	NN
cord-001835-0s7ok4uw	3830	7	of	of	IN
cord-001835-0s7ok4uw	3830	8	one	one	CD
cord-001835-0s7ok4uw	3830	9	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3830	10	bond	bond	NN
cord-001835-0s7ok4uw	3830	11	between	between	IN
cord-001835-0s7ok4uw	3830	12	the	the	DT
cord-001835-0s7ok4uw	3830	13	loop	loop	NN
cord-001835-0s7ok4uw	3830	14	and	and	CC
cord-001835-0s7ok4uw	3830	15	the	the	DT
cord-001835-0s7ok4uw	3830	16	other	other	JJ
cord-001835-0s7ok4uw	3830	17	subunit	subunit	NN
cord-001835-0s7ok4uw	3830	18	caused	cause	VBD
cord-001835-0s7ok4uw	3830	19	a	a	DT
cord-001835-0s7ok4uw	3830	20	small	small	JJ
cord-001835-0s7ok4uw	3830	21	drop	drop	NN
cord-001835-0s7ok4uw	3830	22	in	in	IN
cord-001835-0s7ok4uw	3830	23	stability	stability	NN
cord-001835-0s7ok4uw	3830	24	parameters	parameter	NNS
cord-001835-0s7ok4uw	3830	25	,	,	,
cord-001835-0s7ok4uw	3830	26	whereas	whereas	IN
cord-001835-0s7ok4uw	3830	27	both	both	DT
cord-001835-0s7ok4uw	3830	28	kcat	kcat	NNP
cord-001835-0s7ok4uw	3830	29	and	and	CC
cord-001835-0s7ok4uw	3830	30	Km	Km	NNP
cord-001835-0s7ok4uw	3830	31	were	be	VBD
cord-001835-0s7ok4uw	3830	32	reduced	reduce	VBN
cord-001835-0s7ok4uw	3830	33	by	by	IN
cord-001835-0s7ok4uw	3830	34	about	about	RB
cord-001835-0s7ok4uw	3830	35	half	half	NN
cord-001835-0s7ok4uw	3830	36	,	,	,
cord-001835-0s7ok4uw	3830	37	giving	give	VBG
cord-001835-0s7ok4uw	3830	38	similar	similar	JJ
cord-001835-0s7ok4uw	3830	39	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	3830	40	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3830	41	(	(	-LRB-
cord-001835-0s7ok4uw	3830	42	kcat	kcat	NNP
cord-001835-0s7ok4uw	3830	43	/	/	SYM
cord-001835-0s7ok4uw	3830	44	Km	Km	NNP
cord-001835-0s7ok4uw	3830	45	)	)	-RRB-
cord-001835-0s7ok4uw	3830	46	to	to	IN
cord-001835-0s7ok4uw	3830	47	that	that	DT
cord-001835-0s7ok4uw	3830	48	of	of	IN
cord-001835-0s7ok4uw	3830	49	wild	wild	JJ
cord-001835-0s7ok4uw	3830	50	-	-	HYPH
cord-001835-0s7ok4uw	3830	51	type	type	NN
cord-001835-0s7ok4uw	3830	52	.	.	.
cord-001835-0s7ok4uw	3831	1	Finally	finally	RB
cord-001835-0s7ok4uw	3831	2	,	,	,
cord-001835-0s7ok4uw	3831	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3831	4	changed	change	VBD
cord-001835-0s7ok4uw	3831	5	a	a	DT
cord-001835-0s7ok4uw	3831	6	residue	residue	NN
cord-001835-0s7ok4uw	3831	7	at	at	IN
cord-001835-0s7ok4uw	3831	8	the	the	DT
cord-001835-0s7ok4uw	3831	9	root	root	NN
cord-001835-0s7ok4uw	3831	10	of	of	IN
cord-001835-0s7ok4uw	3831	11	the	the	DT
cord-001835-0s7ok4uw	3831	12	large	large	JJ
cord-001835-0s7ok4uw	3831	13	loop	loop	NN
cord-001835-0s7ok4uw	3831	14	(	(	-LRB-
cord-001835-0s7ok4uw	3831	15	F355Y	f355y	NN
cord-001835-0s7ok4uw	3831	16	)	)	-RRB-
cord-001835-0s7ok4uw	3831	17	such	such	JJ
cord-001835-0s7ok4uw	3831	18	that	that	IN
cord-001835-0s7ok4uw	3831	19	one	one	CD
cord-001835-0s7ok4uw	3831	20	new	new	JJ
cord-001835-0s7ok4uw	3831	21	intersubunit	intersubunit	JJ
cord-001835-0s7ok4uw	3831	22	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3831	23	bond	bond	NN
cord-001835-0s7ok4uw	3831	24	could	could	MD
cord-001835-0s7ok4uw	3831	25	form	form	VB
cord-001835-0s7ok4uw	3831	26	.	.	.
cord-001835-0s7ok4uw	3832	1	This	this	DT
cord-001835-0s7ok4uw	3832	2	variant	variant	NN
cord-001835-0s7ok4uw	3832	3	maintained	maintain	VBD
cord-001835-0s7ok4uw	3832	4	the	the	DT
cord-001835-0s7ok4uw	3832	5	wild	wild	JJ
cord-001835-0s7ok4uw	3832	6	-	-	HYPH
cord-001835-0s7ok4uw	3832	7	type	type	NN
cord-001835-0s7ok4uw	3832	8	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	3832	9	.	.	.
cord-001835-0s7ok4uw	3833	1	In	in	IN
cord-001835-0s7ok4uw	3833	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	3833	3	,	,	,
cord-001835-0s7ok4uw	3833	4	removing	remove	VBG
cord-001835-0s7ok4uw	3833	5	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	3833	6	bonds	bond	NNS
cord-001835-0s7ok4uw	3833	7	connecting	connect	VBG
cord-001835-0s7ok4uw	3833	8	the	the	DT
cord-001835-0s7ok4uw	3833	9	major	major	JJ
cord-001835-0s7ok4uw	3833	10	loop	loop	NN
cord-001835-0s7ok4uw	3833	11	of	of	IN
cord-001835-0s7ok4uw	3833	12	one	one	CD
cord-001835-0s7ok4uw	3833	13	subunit	subunit	NN
cord-001835-0s7ok4uw	3833	14	to	to	IN
cord-001835-0s7ok4uw	3833	15	the	the	DT
cord-001835-0s7ok4uw	3833	16	protein	protein	NN
cord-001835-0s7ok4uw	3833	17	surface	surface	NN
cord-001835-0s7ok4uw	3833	18	of	of	IN
cord-001835-0s7ok4uw	3833	19	the	the	DT
cord-001835-0s7ok4uw	3833	20	other	other	JJ
cord-001835-0s7ok4uw	3833	21	subunit	subunit	NN
cord-001835-0s7ok4uw	3833	22	in	in	IN
cord-001835-0s7ok4uw	3833	23	VAP	VAP	NNP
cord-001835-0s7ok4uw	3833	24	produced	produce	VBD
cord-001835-0s7ok4uw	3833	25	higher	high	JJR
cord-001835-0s7ok4uw	3833	26	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3833	27	activity	activity	NN
cord-001835-0s7ok4uw	3833	28	and	and	CC
cord-001835-0s7ok4uw	3833	29	this	this	DT
cord-001835-0s7ok4uw	3833	30	shows	show	VBZ
cord-001835-0s7ok4uw	3833	31	functional	functional	JJ
cord-001835-0s7ok4uw	3833	32	connections	connection	NNS
cord-001835-0s7ok4uw	3833	33	between	between	IN
cord-001835-0s7ok4uw	3833	34	loop	loop	NN
cord-001835-0s7ok4uw	3833	35	mobility	mobility	NN
cord-001835-0s7ok4uw	3833	36	and	and	CC
cord-001835-0s7ok4uw	3833	37	the	the	DT
cord-001835-0s7ok4uw	3833	38	active	active	JJ
cord-001835-0s7ok4uw	3833	39	site	site	NN
cord-001835-0s7ok4uw	3833	40	.	.	.
cord-001835-0s7ok4uw	3834	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	3834	2	study	study	NN
cord-001835-0s7ok4uw	3834	3	also	also	RB
cord-001835-0s7ok4uw	3834	4	demonstrates	demonstrate	VBZ
cord-001835-0s7ok4uw	3834	5	that	that	IN
cord-001835-0s7ok4uw	3834	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	3834	7	between	between	IN
cord-001835-0s7ok4uw	3834	8	residues	residue	NNS
cord-001835-0s7ok4uw	3834	9	in	in	IN
cord-001835-0s7ok4uw	3834	10	the	the	DT
cord-001835-0s7ok4uw	3834	11	large	large	JJ
cord-001835-0s7ok4uw	3834	12	disordered	disordered	JJ
cord-001835-0s7ok4uw	3834	13	loop	loop	NN
cord-001835-0s7ok4uw	3834	14	and	and	CC
cord-001835-0s7ok4uw	3834	15	the	the	DT
cord-001835-0s7ok4uw	3834	16	opposite	opposite	JJ
cord-001835-0s7ok4uw	3834	17	subunit	subunit	NN
cord-001835-0s7ok4uw	3834	18	in	in	IN
cord-001835-0s7ok4uw	3834	19	the	the	DT
cord-001835-0s7ok4uw	3834	20	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	3834	21	VAP	VAP	NNP
cord-001835-0s7ok4uw	3834	22	are	be	VBP
cord-001835-0s7ok4uw	3834	23	determinants	determinant	NNS
cord-001835-0s7ok4uw	3834	24	of	of	IN
cord-001835-0s7ok4uw	3834	25	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3834	26	stability	stability	NN
cord-001835-0s7ok4uw	3834	27	.	.	.
cord-001835-0s7ok4uw	3835	1	Thus	thus	RB
cord-001835-0s7ok4uw	3835	2	,	,	,
cord-001835-0s7ok4uw	3835	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3835	4	managed	manage	VBD
cord-001835-0s7ok4uw	3835	5	to	to	TO
cord-001835-0s7ok4uw	3835	6	show	show	VB
cord-001835-0s7ok4uw	3835	7	that	that	IN
cord-001835-0s7ok4uw	3835	8	loosening	loosening	NN
cord-001835-0s7ok4uw	3835	9	of	of	IN
cord-001835-0s7ok4uw	3835	10	interface	interface	NN
cord-001835-0s7ok4uw	3835	11	contacts	contact	NNS
cord-001835-0s7ok4uw	3835	12	between	between	IN
cord-001835-0s7ok4uw	3835	13	the	the	DT
cord-001835-0s7ok4uw	3835	14	two	two	CD
cord-001835-0s7ok4uw	3835	15	VAP	VAP	NNP
cord-001835-0s7ok4uw	3835	16	subunits	subunit	NNS
cord-001835-0s7ok4uw	3835	17	by	by	IN
cord-001835-0s7ok4uw	3835	18	replacement	replacement	NN
cord-001835-0s7ok4uw	3835	19	of	of	IN
cord-001835-0s7ok4uw	3835	20	crucial	crucial	JJ
cord-001835-0s7ok4uw	3835	21	residues	residue	NNS
cord-001835-0s7ok4uw	3835	22	provides	provide	VBZ
cord-001835-0s7ok4uw	3835	23	a	a	DT
cord-001835-0s7ok4uw	3835	24	way	way	NN
cord-001835-0s7ok4uw	3835	25	to	to	TO
cord-001835-0s7ok4uw	3835	26	orchestrate	orchestrate	VB
cord-001835-0s7ok4uw	3835	27	structural	structural	JJ
cord-001835-0s7ok4uw	3835	28	and	and	CC
cord-001835-0s7ok4uw	3835	29	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	3835	30	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3835	31	in	in	IN
cord-001835-0s7ok4uw	3835	32	a	a	DT
cord-001835-0s7ok4uw	3835	33	productive	productive	JJ
cord-001835-0s7ok4uw	3835	34	way	way	NN
cord-001835-0s7ok4uw	3835	35	.	.	.
cord-001835-0s7ok4uw	3835	36	 	 	_SP
cord-001835-0s7ok4uw	3836	1	The	the	DT
cord-001835-0s7ok4uw	3836	2	de	de	FW
cord-001835-0s7ok4uw	3836	3	novo	novo	NN
cord-001835-0s7ok4uw	3836	4	design	design	NN
cord-001835-0s7ok4uw	3836	5	of	of	IN
cord-001835-0s7ok4uw	3836	6	artificial	artificial	JJ
cord-001835-0s7ok4uw	3836	7	proteins	protein	NNS
cord-001835-0s7ok4uw	3836	8	arises	arise	VBZ
cord-001835-0s7ok4uw	3836	9	as	as	IN
cord-001835-0s7ok4uw	3836	10	a	a	DT
cord-001835-0s7ok4uw	3836	11	stringent	stringent	JJ
cord-001835-0s7ok4uw	3836	12	test	test	NN
cord-001835-0s7ok4uw	3836	13	of	of	IN
cord-001835-0s7ok4uw	3836	14	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3836	15	understanding	understanding	NN
cord-001835-0s7ok4uw	3836	16	of	of	IN
cord-001835-0s7ok4uw	3836	17	the	the	DT
cord-001835-0s7ok4uw	3836	18	relationship	relationship	NN
cord-001835-0s7ok4uw	3836	19	between	between	IN
cord-001835-0s7ok4uw	3836	20	sequence	sequence	NN
cord-001835-0s7ok4uw	3836	21	,	,	,
cord-001835-0s7ok4uw	3836	22	structure	structure	NN
cord-001835-0s7ok4uw	3836	23	,	,	,
cord-001835-0s7ok4uw	3836	24	and	and	CC
cord-001835-0s7ok4uw	3836	25	function	function	NN
cord-001835-0s7ok4uw	3836	26	.	.	.
cord-001835-0s7ok4uw	3837	1	Examples	example	NNS
cord-001835-0s7ok4uw	3837	2	include	include	VBP
cord-001835-0s7ok4uw	3837	3	the	the	DT
cord-001835-0s7ok4uw	3837	4	design	design	NN
cord-001835-0s7ok4uw	3837	5	of	of	IN
cord-001835-0s7ok4uw	3837	6	a	a	DT
cord-001835-0s7ok4uw	3837	7	four	four	CD
cord-001835-0s7ok4uw	3837	8	a	a	DT
cord-001835-0s7ok4uw	3837	9	-	-	HYPH
cord-001835-0s7ok4uw	3837	10	helix	helix	NN
cord-001835-0s7ok4uw	3837	11	bundle	bundle	NN
cord-001835-0s7ok4uw	3837	12	,	,	,
cord-001835-0s7ok4uw	3837	13	a	a	DT
cord-001835-0s7ok4uw	3837	14	new	new	JJ
cord-001835-0s7ok4uw	3837	15	protein	protein	NN
cord-001835-0s7ok4uw	3837	16	topology	topology	NN
cord-001835-0s7ok4uw	3837	17	called	call	VBD
cord-001835-0s7ok4uw	3837	18	TOP7	TOP7	NNP
cord-001835-0s7ok4uw	3837	19	,	,	,
cord-001835-0s7ok4uw	3837	20	and	and	CC
cord-001835-0s7ok4uw	3837	21	a	a	DT
cord-001835-0s7ok4uw	3837	22	series	series	NN
cord-001835-0s7ok4uw	3837	23	of	of	IN
cord-001835-0s7ok4uw	3837	24	artificial	artificial	JJ
cord-001835-0s7ok4uw	3837	25	(	(	-LRB-
cord-001835-0s7ok4uw	3837	26	ba)8-barrels	ba)8-barrels	NNP
cord-001835-0s7ok4uw	3837	27	called	call	VBN
cord-001835-0s7ok4uw	3837	28	Octarellins	Octarellins	NNP
cord-001835-0s7ok4uw	3837	29	.	.	.
cord-001835-0s7ok4uw	3838	1	However	however	RB
cord-001835-0s7ok4uw	3838	2	,	,	,
cord-001835-0s7ok4uw	3838	3	de	de	FW
cord-001835-0s7ok4uw	3838	4	novo	novo	NNP
cord-001835-0s7ok4uw	3838	5	design	design	NN
cord-001835-0s7ok4uw	3838	6	has	have	VBZ
cord-001835-0s7ok4uw	3838	7	proven	prove	VBN
cord-001835-0s7ok4uw	3838	8	difficult	difficult	JJ
cord-001835-0s7ok4uw	3838	9	for	for	IN
cord-001835-0s7ok4uw	3838	10	larger	large	JJR
cord-001835-0s7ok4uw	3838	11	proteins	protein	NNS
cord-001835-0s7ok4uw	3838	12	with	with	IN
cord-001835-0s7ok4uw	3838	13	more	more	JJR
cord-001835-0s7ok4uw	3838	14	than	than	IN
cord-001835-0s7ok4uw	3838	15	100	100	CD
cord-001835-0s7ok4uw	3838	16	amino	amino	NN
cord-001835-0s7ok4uw	3838	17	acids	acid	NNS
cord-001835-0s7ok4uw	3838	18	.	.	.
cord-001835-0s7ok4uw	3839	1	Here	here	RB
cord-001835-0s7ok4uw	3839	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3839	3	present	present	VBP
cord-001835-0s7ok4uw	3839	4	two	two	CD
cord-001835-0s7ok4uw	3839	5	methods	method	NNS
cord-001835-0s7ok4uw	3839	6	to	to	TO
cord-001835-0s7ok4uw	3839	7	generate	generate	VB
cord-001835-0s7ok4uw	3839	8	the	the	DT
cord-001835-0s7ok4uw	3839	9	backbone	backbone	NN
cord-001835-0s7ok4uw	3839	10	and	and	CC
cord-001835-0s7ok4uw	3839	11	to	to	TO
cord-001835-0s7ok4uw	3839	12	perform	perform	VB
cord-001835-0s7ok4uw	3839	13	the	the	DT
cord-001835-0s7ok4uw	3839	14	de	de	FW
cord-001835-0s7ok4uw	3839	15	novo	novo	NNP
cord-001835-0s7ok4uw	3839	16	design	design	NN
cord-001835-0s7ok4uw	3839	17	of	of	IN
cord-001835-0s7ok4uw	3839	18	(	(	-LRB-
cord-001835-0s7ok4uw	3839	19	ba)8-barrel	ba)8-barrel	NN
cord-001835-0s7ok4uw	3839	20	proteins	protein	NNS
cord-001835-0s7ok4uw	3839	21	through	through	IN
cord-001835-0s7ok4uw	3839	22	the	the	DT
cord-001835-0s7ok4uw	3839	23	use	use	NN
cord-001835-0s7ok4uw	3839	24	of	of	IN
cord-001835-0s7ok4uw	3839	25	the	the	DT
cord-001835-0s7ok4uw	3839	26	software	software	NN
cord-001835-0s7ok4uw	3839	27	ROSETTA	ROSETTA	NNP
cord-001835-0s7ok4uw	3839	28	;	;	:
cord-001835-0s7ok4uw	3839	29	both	both	DT
cord-001835-0s7ok4uw	3839	30	have	have	VBP
cord-001835-0s7ok4uw	3839	31	different	different	JJ
cord-001835-0s7ok4uw	3839	32	advantages	advantage	NNS
cord-001835-0s7ok4uw	3839	33	and	and	CC
cord-001835-0s7ok4uw	3839	34	limitations	limitation	NNS
cord-001835-0s7ok4uw	3839	35	.	.	.
cord-001835-0s7ok4uw	3840	1	The	the	DT
cord-001835-0s7ok4uw	3840	2	first	first	JJ
cord-001835-0s7ok4uw	3840	3	method	method	NN
cord-001835-0s7ok4uw	3840	4	for	for	IN
cord-001835-0s7ok4uw	3840	5	generating	generate	VBG
cord-001835-0s7ok4uw	3840	6	the	the	DT
cord-001835-0s7ok4uw	3840	7	backbone	backbone	NN
cord-001835-0s7ok4uw	3840	8	is	be	VBZ
cord-001835-0s7ok4uw	3840	9	knowledge	knowledge	NN
cord-001835-0s7ok4uw	3840	10	-	-	HYPH
cord-001835-0s7ok4uw	3840	11	based	base	VBN
cord-001835-0s7ok4uw	3840	12	,	,	,
cord-001835-0s7ok4uw	3840	13	with	with	IN
cord-001835-0s7ok4uw	3840	14	a	a	DT
cord-001835-0s7ok4uw	3840	15	first	first	JJ
cord-001835-0s7ok4uw	3840	16	analysis	analysis	NN
cord-001835-0s7ok4uw	3840	17	of	of	IN
cord-001835-0s7ok4uw	3840	18	a	a	DT
cord-001835-0s7ok4uw	3840	19	non	non	JJ
cord-001835-0s7ok4uw	3840	20	-	-	JJ
cord-001835-0s7ok4uw	3840	21	redundant	redundant	JJ
cord-001835-0s7ok4uw	3840	22	database	database	NN
cord-001835-0s7ok4uw	3840	23	of	of	IN
cord-001835-0s7ok4uw	3840	24	natural	natural	JJ
cord-001835-0s7ok4uw	3840	25	(	(	-LRB-
cord-001835-0s7ok4uw	3840	26	ba)8-barrel	ba)8-barrel	NN
cord-001835-0s7ok4uw	3840	27	proteins	protein	NNS
cord-001835-0s7ok4uw	3840	28	in	in	IN
cord-001835-0s7ok4uw	3840	29	order	order	NN
cord-001835-0s7ok4uw	3840	30	to	to	TO
cord-001835-0s7ok4uw	3840	31	obtain	obtain	VB
cord-001835-0s7ok4uw	3840	32	statistical	statistical	JJ
cord-001835-0s7ok4uw	3840	33	analysis	analysis	NN
cord-001835-0s7ok4uw	3840	34	on	on	IN
cord-001835-0s7ok4uw	3840	35	preferred	preferred	JJ
cord-001835-0s7ok4uw	3840	36	secondary	secondary	JJ
cord-001835-0s7ok4uw	3840	37	structure	structure	NN
cord-001835-0s7ok4uw	3840	38	element	element	NN
cord-001835-0s7ok4uw	3840	39	length	length	NN
cord-001835-0s7ok4uw	3840	40	and	and	CC
cord-001835-0s7ok4uw	3840	41	amino	amino	JJ
cord-001835-0s7ok4uw	3840	42	acidic	acidic	JJ
cord-001835-0s7ok4uw	3840	43	propensities	propensity	NNS
cord-001835-0s7ok4uw	3840	44	.	.	.
cord-001835-0s7ok4uw	3841	1	With	with	IN
cord-001835-0s7ok4uw	3841	2	this	this	DT
cord-001835-0s7ok4uw	3841	3	information	information	NN
cord-001835-0s7ok4uw	3841	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3841	5	use	use	VBP
cord-001835-0s7ok4uw	3841	6	the	the	DT
cord-001835-0s7ok4uw	3841	7	ROSETTA	ROSETTA	NNP
cord-001835-0s7ok4uw	3841	8	CM	CM	NNP
cord-001835-0s7ok4uw	3841	9	software	software	NN
cord-001835-0s7ok4uw	3841	10	to	to	TO
cord-001835-0s7ok4uw	3841	11	create	create	VB
cord-001835-0s7ok4uw	3841	12	more	more	JJR
cord-001835-0s7ok4uw	3841	13	than	than	IN
cord-001835-0s7ok4uw	3841	14	1000	1000	CD
cord-001835-0s7ok4uw	3841	15	models	model	NNS
cord-001835-0s7ok4uw	3841	16	which	which	WDT
cord-001835-0s7ok4uw	3841	17	are	be	VBP
cord-001835-0s7ok4uw	3841	18	then	then	RB
cord-001835-0s7ok4uw	3841	19	ranked	rank	VBN
cord-001835-0s7ok4uw	3841	20	in	in	IN
cord-001835-0s7ok4uw	3841	21	term	term	NN
cord-001835-0s7ok4uw	3841	22	of	of	IN
cord-001835-0s7ok4uw	3841	23	ROSETTA	ROSETTA	NNP
cord-001835-0s7ok4uw	3841	24	energy	energy	NN
cord-001835-0s7ok4uw	3841	25	.	.	.
cord-001835-0s7ok4uw	3842	1	The	the	DT
cord-001835-0s7ok4uw	3842	2	second	second	JJ
cord-001835-0s7ok4uw	3842	3	method	method	NN
cord-001835-0s7ok4uw	3842	4	is	be	VBZ
cord-001835-0s7ok4uw	3842	5	performed	perform	VBN
cord-001835-0s7ok4uw	3842	6	with	with	IN
cord-001835-0s7ok4uw	3842	7	the	the	DT
cord-001835-0s7ok4uw	3842	8	ParametricDesign	ParametricDesign	NNP
cord-001835-0s7ok4uw	3842	9	package	package	NN
cord-001835-0s7ok4uw	3842	10	of	of	IN
cord-001835-0s7ok4uw	3842	11	ROSETTA	ROSETTA	NNP
cord-001835-0s7ok4uw	3842	12	,	,	,
cord-001835-0s7ok4uw	3842	13	in	in	IN
cord-001835-0s7ok4uw	3842	14	which	which	WDT
cord-001835-0s7ok4uw	3842	15	only	only	RB
cord-001835-0s7ok4uw	3842	16	geometrical	geometrical	JJ
cord-001835-0s7ok4uw	3842	17	information	information	NN
cord-001835-0s7ok4uw	3842	18	are	be	VBP
cord-001835-0s7ok4uw	3842	19	requested	request	VBN
cord-001835-0s7ok4uw	3842	20	(	(	-LRB-
cord-001835-0s7ok4uw	3842	21	number	number	NN
cord-001835-0s7ok4uw	3842	22	of	of	IN
cord-001835-0s7ok4uw	3842	23	strands	strand	NNS
cord-001835-0s7ok4uw	3842	24	and	and	CC
cord-001835-0s7ok4uw	3842	25	helices	helix	NNS
cord-001835-0s7ok4uw	3842	26	,	,	,
cord-001835-0s7ok4uw	3842	27	radius	radius	NN
cord-001835-0s7ok4uw	3842	28	of	of	IN
cord-001835-0s7ok4uw	3842	29	the	the	DT
cord-001835-0s7ok4uw	3842	30	b	b	NN
cord-001835-0s7ok4uw	3842	31	-	-	:
cord-001835-0s7ok4uw	3842	32	and	and	CC
cord-001835-0s7ok4uw	3842	33	a	a	DT
cord-001835-0s7ok4uw	3842	34	-	-	HYPH
cord-001835-0s7ok4uw	3842	35	barrels	barrel	NNS
cord-001835-0s7ok4uw	3842	36	,	,	,
cord-001835-0s7ok4uw	3842	37	degree	degree	NN
cord-001835-0s7ok4uw	3842	38	of	of	IN
cord-001835-0s7ok4uw	3842	39	inclination	inclination	NN
cord-001835-0s7ok4uw	3842	40	,	,	,
cord-001835-0s7ok4uw	3842	41	orientation	orientation	NN
cord-001835-0s7ok4uw	3842	42	of	of	IN
cord-001835-0s7ok4uw	3842	43	the	the	DT
cord-001835-0s7ok4uw	3842	44	side	side	NN
cord-001835-0s7ok4uw	3842	45	chains	chain	NNS
cord-001835-0s7ok4uw	3842	46	,	,	,
cord-001835-0s7ok4uw	3842	47	among	among	IN
cord-001835-0s7ok4uw	3842	48	others	other	NNS
cord-001835-0s7ok4uw	3842	49	)	)	-RRB-
cord-001835-0s7ok4uw	3842	50	.	.	.
cord-001835-0s7ok4uw	3843	1	Both	both	DT
cord-001835-0s7ok4uw	3843	2	methods	method	NNS
cord-001835-0s7ok4uw	3843	3	contain	contain	VBP
cord-001835-0s7ok4uw	3843	4	a	a	DT
cord-001835-0s7ok4uw	3843	5	step	step	NN
cord-001835-0s7ok4uw	3843	6	of	of	IN
cord-001835-0s7ok4uw	3843	7	loop	loop	NN
cord-001835-0s7ok4uw	3843	8	refinement	refinement	NN
cord-001835-0s7ok4uw	3843	9	and	and	CC
cord-001835-0s7ok4uw	3843	10	multiple	multiple	JJ
cord-001835-0s7ok4uw	3843	11	steps	step	NNS
cord-001835-0s7ok4uw	3843	12	of	of	IN
cord-001835-0s7ok4uw	3843	13	sequence	sequence	NN
cord-001835-0s7ok4uw	3843	14	design	design	NN
cord-001835-0s7ok4uw	3843	15	with	with	IN
cord-001835-0s7ok4uw	3843	16	the	the	DT
cord-001835-0s7ok4uw	3843	17	package	package	NN
cord-001835-0s7ok4uw	3843	18	ROSETTA	ROSETTA	NNP
cord-001835-0s7ok4uw	3843	19	Design	Design	NNP
cord-001835-0s7ok4uw	3843	20	,	,	,
cord-001835-0s7ok4uw	3843	21	in	in	IN
cord-001835-0s7ok4uw	3843	22	order	order	NN
cord-001835-0s7ok4uw	3843	23	to	to	TO
cord-001835-0s7ok4uw	3843	24	find	find	VB
cord-001835-0s7ok4uw	3843	25	low	low	JJ
cord-001835-0s7ok4uw	3843	26	scoring	scoring	NN
cord-001835-0s7ok4uw	3843	27	amino	amino	NN
cord-001835-0s7ok4uw	3843	28	acid	acid	NN
cord-001835-0s7ok4uw	3843	29	sequences	sequence	NNS
cord-001835-0s7ok4uw	3843	30	for	for	IN
cord-001835-0s7ok4uw	3843	31	each	each	DT
cord-001835-0s7ok4uw	3843	32	of	of	IN
cord-001835-0s7ok4uw	3843	33	the	the	DT
cord-001835-0s7ok4uw	3843	34	starting	start	VBG
cord-001835-0s7ok4uw	3843	35	backbone	backbone	NN
cord-001835-0s7ok4uw	3843	36	conformations	conformation	NNS
cord-001835-0s7ok4uw	3843	37	.	.	.
cord-001835-0s7ok4uw	3844	1	Thousands	thousand	NNS
cord-001835-0s7ok4uw	3844	2	of	of	IN
cord-001835-0s7ok4uw	3844	3	models	model	NNS
cord-001835-0s7ok4uw	3844	4	will	will	MD
cord-001835-0s7ok4uw	3844	5	be	be	VB
cord-001835-0s7ok4uw	3844	6	generated	generate	VBN
cord-001835-0s7ok4uw	3844	7	by	by	IN
cord-001835-0s7ok4uw	3844	8	both	both	DT
cord-001835-0s7ok4uw	3844	9	methods	method	NNS
cord-001835-0s7ok4uw	3844	10	and	and	CC
cord-001835-0s7ok4uw	3844	11	then	then	RB
cord-001835-0s7ok4uw	3844	12	analyzed	analyze	VBN
cord-001835-0s7ok4uw	3844	13	in	in	IN
cord-001835-0s7ok4uw	3844	14	term	term	NN
cord-001835-0s7ok4uw	3844	15	of	of	IN
cord-001835-0s7ok4uw	3844	16	sequence	sequence	NN
cord-001835-0s7ok4uw	3844	17	similarity	similarity	NN
cord-001835-0s7ok4uw	3844	18	,	,	,
cord-001835-0s7ok4uw	3844	19	secondary	secondary	JJ
cord-001835-0s7ok4uw	3844	20	and	and	CC
cord-001835-0s7ok4uw	3844	21	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	3844	22	structure	structure	NN
cord-001835-0s7ok4uw	3844	23	prediction	prediction	NN
cord-001835-0s7ok4uw	3844	24	,	,	,
cord-001835-0s7ok4uw	3844	25	and	and	CC
cord-001835-0s7ok4uw	3844	26	stability	stability	NN
cord-001835-0s7ok4uw	3844	27	by	by	IN
cord-001835-0s7ok4uw	3844	28	molecular	molecular	JJ
cord-001835-0s7ok4uw	3844	29	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3844	30	simulations	simulation	NNS
cord-001835-0s7ok4uw	3844	31	.	.	.
cord-001835-0s7ok4uw	3845	1	The	the	DT
cord-001835-0s7ok4uw	3845	2	30	30	CD
cord-001835-0s7ok4uw	3845	3	best	good	JJS
cord-001835-0s7ok4uw	3845	4	candidate	candidate	NN
cord-001835-0s7ok4uw	3845	5	sequences	sequence	NNS
cord-001835-0s7ok4uw	3845	6	will	will	MD
cord-001835-0s7ok4uw	3845	7	be	be	VB
cord-001835-0s7ok4uw	3845	8	selected	select	VBN
cord-001835-0s7ok4uw	3845	9	for	for	IN
cord-001835-0s7ok4uw	3845	10	the	the	DT
cord-001835-0s7ok4uw	3845	11	experimental	experimental	JJ
cord-001835-0s7ok4uw	3845	12	verification	verification	NN
cord-001835-0s7ok4uw	3845	13	.	.	.
cord-001835-0s7ok4uw	3846	1	In	in	IN
cord-001835-0s7ok4uw	3846	2	order	order	NN
cord-001835-0s7ok4uw	3846	3	to	to	TO
cord-001835-0s7ok4uw	3846	4	identify	identify	VB
cord-001835-0s7ok4uw	3846	5	a	a	DT
cord-001835-0s7ok4uw	3846	6	putative	putative	JJ
cord-001835-0s7ok4uw	3846	7	successfully	successfully	RB
cord-001835-0s7ok4uw	3846	8	design	design	NN
cord-001835-0s7ok4uw	3846	9	,	,	,
cord-001835-0s7ok4uw	3846	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	3846	11	added	add	VBD
cord-001835-0s7ok4uw	3846	12	a	a	DT
cord-001835-0s7ok4uw	3846	13	metal	metal	NN
cord-001835-0s7ok4uw	3846	14	binding	bind	VBG
cord-001835-0s7ok4uw	3846	15	site	site	NN
cord-001835-0s7ok4uw	3846	16	during	during	IN
cord-001835-0s7ok4uw	3846	17	the	the	DT
cord-001835-0s7ok4uw	3846	18	design	design	NN
cord-001835-0s7ok4uw	3846	19	step	step	NN
cord-001835-0s7ok4uw	3846	20	.	.	.
cord-001835-0s7ok4uw	3847	1	All	all	PDT
cord-001835-0s7ok4uw	3847	2	the	the	DT
cord-001835-0s7ok4uw	3847	3	proteins	protein	NNS
cord-001835-0s7ok4uw	3847	4	will	will	MD
cord-001835-0s7ok4uw	3847	5	be	be	VB
cord-001835-0s7ok4uw	3847	6	expressed	express	VBN
cord-001835-0s7ok4uw	3847	7	in	in	IN
cord-001835-0s7ok4uw	3847	8	E.	E.	NNP
cord-001835-0s7ok4uw	3847	9	coli	coli	NNS
cord-001835-0s7ok4uw	3847	10	.	.	.
cord-001835-0s7ok4uw	3848	1	The	the	DT
cord-001835-0s7ok4uw	3848	2	solubility	solubility	NN
cord-001835-0s7ok4uw	3848	3	of	of	IN
cord-001835-0s7ok4uw	3848	4	the	the	DT
cord-001835-0s7ok4uw	3848	5	designed	design	VBN
cord-001835-0s7ok4uw	3848	6	proteins	protein	NNS
cord-001835-0s7ok4uw	3848	7	inside	inside	IN
cord-001835-0s7ok4uw	3848	8	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	3848	9	will	will	MD
cord-001835-0s7ok4uw	3848	10	be	be	VB
cord-001835-0s7ok4uw	3848	11	determined	determine	VBN
cord-001835-0s7ok4uw	3848	12	thanks	thank	NNS
cord-001835-0s7ok4uw	3848	13	to	to	IN
cord-001835-0s7ok4uw	3848	14	the	the	DT
cord-001835-0s7ok4uw	3848	15	fusion	fusion	NN
cord-001835-0s7ok4uw	3848	16	to	to	IN
cord-001835-0s7ok4uw	3848	17	green	green	JJ
cord-001835-0s7ok4uw	3848	18	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3848	19	protein	protein	NN
cord-001835-0s7ok4uw	3848	20	(	(	-LRB-
cord-001835-0s7ok4uw	3848	21	GFP	GFP	NNP
cord-001835-0s7ok4uw	3848	22	)	)	-RRB-
cord-001835-0s7ok4uw	3848	23	.	.	.
cord-001835-0s7ok4uw	3849	1	Solubility	solubility	NN
cord-001835-0s7ok4uw	3849	2	,	,	,
cord-001835-0s7ok4uw	3849	3	stability	stability	NN
cord-001835-0s7ok4uw	3849	4	,	,	,
cord-001835-0s7ok4uw	3849	5	secondary	secondary	JJ
cord-001835-0s7ok4uw	3849	6	structure	structure	NN
cord-001835-0s7ok4uw	3849	7	,	,	,
cord-001835-0s7ok4uw	3849	8	and	and	CC
cord-001835-0s7ok4uw	3849	9	cooperativity	cooperativity	NN
cord-001835-0s7ok4uw	3849	10	of	of	IN
cord-001835-0s7ok4uw	3849	11	folding	folding	NN
cord-001835-0s7ok4uw	3849	12	will	will	MD
cord-001835-0s7ok4uw	3849	13	be	be	VB
cord-001835-0s7ok4uw	3849	14	assessed	assess	VBN
cord-001835-0s7ok4uw	3849	15	for	for	IN
cord-001835-0s7ok4uw	3849	16	each	each	DT
cord-001835-0s7ok4uw	3849	17	protein	protein	NN
cord-001835-0s7ok4uw	3849	18	before	before	IN
cord-001835-0s7ok4uw	3849	19	determination	determination	NN
cord-001835-0s7ok4uw	3849	20	of	of	IN
cord-001835-0s7ok4uw	3849	21	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3849	22	three	three	CD
cord-001835-0s7ok4uw	3849	23	-	-	HYPH
cord-001835-0s7ok4uw	3849	24	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	3849	25	structure	structure	NN
cord-001835-0s7ok4uw	3849	26	.	.	.
cord-001835-0s7ok4uw	3850	1	Construction	construction	NN
cord-001835-0s7ok4uw	3850	2	of	of	IN
cord-001835-0s7ok4uw	3850	3	protein	protein	NN
cord-001835-0s7ok4uw	3850	4	capsule	capsule	NN
cord-001835-0s7ok4uw	3850	5	possessing	possess	VBG
cord-001835-0s7ok4uw	3850	6	drugs	drug	NNS
cord-001835-0s7ok4uw	3850	7	controlled	control	VBN
cord-001835-0s7ok4uw	3850	8	release	release	NN
cord-001835-0s7ok4uw	3850	9	ability	ability	NN
cord-001835-0s7ok4uw	3850	10	Shota	Shota	NNP
cord-001835-0s7ok4uw	3850	11	Shimizu	Shimizu	NNP
cord-001835-0s7ok4uw	3850	12	1	1	CD
cord-001835-0s7ok4uw	3850	13	,	,	,
cord-001835-0s7ok4uw	3850	14	Masatoshi	Masatoshi	NNP
cord-001835-0s7ok4uw	3850	15	Nakatsuji	Nakatsuji	NNP
cord-001835-0s7ok4uw	3850	16	1	1	CD
cord-001835-0s7ok4uw	3850	17	,	,	,
cord-001835-0s7ok4uw	3850	18	Keisuke	Keisuke	NNP
cord-001835-0s7ok4uw	3850	19	Yamaguchi	Yamaguchi	NNP
cord-001835-0s7ok4uw	3850	20	1	1	CD
cord-001835-0s7ok4uw	3850	21	,	,	,
cord-001835-0s7ok4uw	3850	22	Yuya	Yuya	NNP
cord-001835-0s7ok4uw	3850	23	Sano	Sano	NNP
cord-001835-0s7ok4uw	3850	24	1	1	CD
cord-001835-0s7ok4uw	3850	25	,	,	,
cord-001835-0s7ok4uw	3850	26	Yuya	Yuya	NNP
cord-001835-0s7ok4uw	3850	27	Miyamoto	Miyamoto	NNP
cord-001835-0s7ok4uw	3850	28	1	1	CD
cord-001835-0s7ok4uw	3850	29	,	,	,
cord-001835-0s7ok4uw	3850	30	Takashi	Takashi	NNP
cord-001835-0s7ok4uw	3850	31	Inui	Inui	NNP
cord-001835-0s7ok4uw	3851	1	1	1	LS
cord-001835-0s7ok4uw	3851	2	1	1	CD
cord-001835-0s7ok4uw	3851	3	Most	Most	JJS
cord-001835-0s7ok4uw	3851	4	compounds	compound	NNS
cord-001835-0s7ok4uw	3851	5	that	that	WDT
cord-001835-0s7ok4uw	3851	6	exhibit	exhibit	VBP
cord-001835-0s7ok4uw	3851	7	anti	anti	JJ
cord-001835-0s7ok4uw	3851	8	-	-	JJ
cord-001835-0s7ok4uw	3851	9	tumor	tumor	JJ
cord-001835-0s7ok4uw	3851	10	activities	activity	NNS
cord-001835-0s7ok4uw	3851	11	are	be	VBP
cord-001835-0s7ok4uw	3851	12	water	water	NN
cord-001835-0s7ok4uw	3851	13	-	-	HYPH
cord-001835-0s7ok4uw	3851	14	insoluble	insoluble	JJ
cord-001835-0s7ok4uw	3851	15	,	,	,
cord-001835-0s7ok4uw	3851	16	thus	thus	RB
cord-001835-0s7ok4uw	3851	17	limiting	limit	VBG
cord-001835-0s7ok4uw	3851	18	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3851	19	clinical	clinical	JJ
cord-001835-0s7ok4uw	3851	20	use	use	NN
cord-001835-0s7ok4uw	3851	21	.	.	.
cord-001835-0s7ok4uw	3852	1	Chemical	chemical	JJ
cord-001835-0s7ok4uw	3852	2	modification	modification	NN
cord-001835-0s7ok4uw	3852	3	of	of	IN
cord-001835-0s7ok4uw	3852	4	these	these	DT
cord-001835-0s7ok4uw	3852	5	compounds	compound	NNS
cord-001835-0s7ok4uw	3852	6	and	and	CC
cord-001835-0s7ok4uw	3852	7	the	the	DT
cord-001835-0s7ok4uw	3852	8	use	use	NN
cord-001835-0s7ok4uw	3852	9	of	of	IN
cord-001835-0s7ok4uw	3852	10	solubilizing	solubilize	VBG
cord-001835-0s7ok4uw	3852	11	agents	agent	NNS
cord-001835-0s7ok4uw	3852	12	such	such	JJ
cord-001835-0s7ok4uw	3852	13	as	as	IN
cord-001835-0s7ok4uw	3852	14	organic	organic	JJ
cord-001835-0s7ok4uw	3852	15	solvents	solvent	NNS
cord-001835-0s7ok4uw	3852	16	,	,	,
cord-001835-0s7ok4uw	3852	17	surfactants	surfactant	NNS
cord-001835-0s7ok4uw	3852	18	and	and	CC
cord-001835-0s7ok4uw	3852	19	pH	ph	NN
cord-001835-0s7ok4uw	3852	20	modifiers	modifier	NNS
cord-001835-0s7ok4uw	3852	21	improve	improve	VBP
cord-001835-0s7ok4uw	3852	22	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3852	23	solubility	solubility	NN
cord-001835-0s7ok4uw	3852	24	.	.	.
cord-001835-0s7ok4uw	3853	1	However	however	RB
cord-001835-0s7ok4uw	3853	2	,	,	,
cord-001835-0s7ok4uw	3853	3	chemical	chemical	JJ
cord-001835-0s7ok4uw	3853	4	modification	modification	NN
cord-001835-0s7ok4uw	3853	5	of	of	IN
cord-001835-0s7ok4uw	3853	6	compounds	compound	NNS
cord-001835-0s7ok4uw	3853	7	decreases	decrease	VBZ
cord-001835-0s7ok4uw	3853	8	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3853	9	potency	potency	NN
cord-001835-0s7ok4uw	3853	10	,	,	,
cord-001835-0s7ok4uw	3853	11	and	and	CC
cord-001835-0s7ok4uw	3853	12	the	the	DT
cord-001835-0s7ok4uw	3853	13	use	use	NN
cord-001835-0s7ok4uw	3853	14	of	of	IN
cord-001835-0s7ok4uw	3853	15	solubilizing	solubilize	VBG
cord-001835-0s7ok4uw	3853	16	agents	agent	NNS
cord-001835-0s7ok4uw	3853	17	causes	cause	VBZ
cord-001835-0s7ok4uw	3853	18	toxicity	toxicity	NN
cord-001835-0s7ok4uw	3853	19	in	in	IN
cord-001835-0s7ok4uw	3853	20	many	many	JJ
cord-001835-0s7ok4uw	3853	21	cases	case	NNS
cord-001835-0s7ok4uw	3853	22	.	.	.
cord-001835-0s7ok4uw	3854	1	Thus	thus	RB
cord-001835-0s7ok4uw	3854	2	,	,	,
cord-001835-0s7ok4uw	3854	3	drug	drug	NN
cord-001835-0s7ok4uw	3854	4	delivery	delivery	NN
cord-001835-0s7ok4uw	3854	5	systems	system	NNS
cord-001835-0s7ok4uw	3854	6	(	(	-LRB-
cord-001835-0s7ok4uw	3854	7	DDS	DDS	NNP
cord-001835-0s7ok4uw	3854	8	)	)	-RRB-
cord-001835-0s7ok4uw	3854	9	for	for	IN
cord-001835-0s7ok4uw	3854	10	poorly	poorly	RB
cord-001835-0s7ok4uw	3854	11	water	water	NN
cord-001835-0s7ok4uw	3854	12	-	-	HYPH
cord-001835-0s7ok4uw	3854	13	soluble	soluble	JJ
cord-001835-0s7ok4uw	3854	14	anti	anti	JJ
cord-001835-0s7ok4uw	3854	15	-	-	JJ
cord-001835-0s7ok4uw	3854	16	tumor	tumor	JJ
cord-001835-0s7ok4uw	3854	17	drugs	drug	NNS
cord-001835-0s7ok4uw	3854	18	which	which	WDT
cord-001835-0s7ok4uw	3854	19	exploit	exploit	VBP
cord-001835-0s7ok4uw	3854	20	liposomes	liposome	NNS
cord-001835-0s7ok4uw	3854	21	,	,	,
cord-001835-0s7ok4uw	3854	22	cyclodextrins	cyclodextrin	NNS
cord-001835-0s7ok4uw	3854	23	,	,	,
cord-001835-0s7ok4uw	3854	24	and	and	CC
cord-001835-0s7ok4uw	3854	25	lipid	lipid	NN
cord-001835-0s7ok4uw	3854	26	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	3854	27	have	have	VBP
cord-001835-0s7ok4uw	3854	28	been	be	VBN
cord-001835-0s7ok4uw	3854	29	studied	study	VBN
cord-001835-0s7ok4uw	3854	30	intensely	intensely	RB
cord-001835-0s7ok4uw	3854	31	.	.	.
cord-001835-0s7ok4uw	3855	1	In	in	IN
cord-001835-0s7ok4uw	3855	2	these	these	DT
cord-001835-0s7ok4uw	3855	3	DDS	DDS	NNP
cord-001835-0s7ok4uw	3855	4	,	,	,
cord-001835-0s7ok4uw	3855	5	the	the	DT
cord-001835-0s7ok4uw	3855	6	controlled	control	VBN
cord-001835-0s7ok4uw	3855	7	release	release	NN
cord-001835-0s7ok4uw	3855	8	of	of	IN
cord-001835-0s7ok4uw	3855	9	drugs	drug	NNS
cord-001835-0s7ok4uw	3855	10	from	from	IN
cord-001835-0s7ok4uw	3855	11	the	the	DT
cord-001835-0s7ok4uw	3855	12	delivery	delivery	NN
cord-001835-0s7ok4uw	3855	13	vehicle	vehicle	NN
cord-001835-0s7ok4uw	3855	14	is	be	VBZ
cord-001835-0s7ok4uw	3855	15	one	one	CD
cord-001835-0s7ok4uw	3855	16	of	of	IN
cord-001835-0s7ok4uw	3855	17	the	the	DT
cord-001835-0s7ok4uw	3855	18	most	most	RBS
cord-001835-0s7ok4uw	3855	19	important	important	JJ
cord-001835-0s7ok4uw	3855	20	functions	function	NNS
cord-001835-0s7ok4uw	3855	21	.	.	.
cord-001835-0s7ok4uw	3856	1	Selective	selective	JJ
cord-001835-0s7ok4uw	3856	2	release	release	NN
cord-001835-0s7ok4uw	3856	3	in	in	IN
cord-001835-0s7ok4uw	3856	4	target	target	NN
cord-001835-0s7ok4uw	3856	5	cells	cell	NNS
cord-001835-0s7ok4uw	3856	6	leads	lead	VBZ
cord-001835-0s7ok4uw	3856	7	to	to	TO
cord-001835-0s7ok4uw	3856	8	adequate	adequate	VB
cord-001835-0s7ok4uw	3856	9	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	3856	10	efficacy	efficacy	NN
cord-001835-0s7ok4uw	3856	11	with	with	IN
cord-001835-0s7ok4uw	3856	12	few	few	JJ
cord-001835-0s7ok4uw	3856	13	side	side	NN
cord-001835-0s7ok4uw	3856	14	effects	effect	NNS
cord-001835-0s7ok4uw	3856	15	.	.	.
cord-001835-0s7ok4uw	3857	1	In	in	IN
cord-001835-0s7ok4uw	3857	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3857	3	laboratory	laboratory	NN
cord-001835-0s7ok4uw	3857	4	,	,	,
cord-001835-0s7ok4uw	3857	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3857	6	have	have	VBP
cord-001835-0s7ok4uw	3857	7	already	already	RB
cord-001835-0s7ok4uw	3857	8	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	3857	9	that	that	IN
cord-001835-0s7ok4uw	3857	10	lipocalin	lipocalin	NN
cord-001835-0s7ok4uw	3857	11	-	-	HYPH
cord-001835-0s7ok4uw	3857	12	type	type	NN
cord-001835-0s7ok4uw	3857	13	prostaglandin	prostaglandin	NN
cord-001835-0s7ok4uw	3857	14	D	d	NN
cord-001835-0s7ok4uw	3857	15	synthase	synthase	NN
cord-001835-0s7ok4uw	3857	16	(	(	-LRB-
cord-001835-0s7ok4uw	3857	17	L	L	NNP
cord-001835-0s7ok4uw	3857	18	-	-	HYPH
cord-001835-0s7ok4uw	3857	19	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3857	20	)	)	-RRB-
cord-001835-0s7ok4uw	3857	21	,	,	,
cord-001835-0s7ok4uw	3857	22	an	an	DT
cord-001835-0s7ok4uw	3857	23	intravital	intravital	JJ
cord-001835-0s7ok4uw	3857	24	transporter	transporter	NN
cord-001835-0s7ok4uw	3857	25	protein	protein	NN
cord-001835-0s7ok4uw	3857	26	,	,	,
cord-001835-0s7ok4uw	3857	27	is	be	VBZ
cord-001835-0s7ok4uw	3857	28	a	a	DT
cord-001835-0s7ok4uw	3857	29	novel	novel	JJ
cord-001835-0s7ok4uw	3857	30	and	and	CC
cord-001835-0s7ok4uw	3857	31	valid	valid	JJ
cord-001835-0s7ok4uw	3857	32	drug	drug	NN
cord-001835-0s7ok4uw	3857	33	delivery	delivery	NN
cord-001835-0s7ok4uw	3857	34	vehicle	vehicle	NN
cord-001835-0s7ok4uw	3857	35	for	for	IN
cord-001835-0s7ok4uw	3857	36	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3857	37	,	,	,
cord-001835-0s7ok4uw	3857	38	a	a	DT
cord-001835-0s7ok4uw	3857	39	poorly	poorly	RB
cord-001835-0s7ok4uw	3857	40	water	water	NN
cord-001835-0s7ok4uw	3857	41	-	-	HYPH
cord-001835-0s7ok4uw	3857	42	soluble	soluble	JJ
cord-001835-0s7ok4uw	3857	43	anti	anti	JJ
cord-001835-0s7ok4uw	3857	44	-	-	JJ
cord-001835-0s7ok4uw	3857	45	tumor	tumor	JJ
cord-001835-0s7ok4uw	3857	46	drug	drug	NN
cord-001835-0s7ok4uw	3857	47	.	.	.
cord-001835-0s7ok4uw	3858	1	In	in	IN
cord-001835-0s7ok4uw	3858	2	this	this	DT
cord-001835-0s7ok4uw	3858	3	study	study	NN
cord-001835-0s7ok4uw	3858	4	,	,	,
cord-001835-0s7ok4uw	3858	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3858	6	generated	generate	VBD
cord-001835-0s7ok4uw	3858	7	L	L	NNP
cord-001835-0s7ok4uw	3858	8	-	-	HYPH
cord-001835-0s7ok4uw	3858	9	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3858	10	-	-	HYPH
cord-001835-0s7ok4uw	3858	11	based	base	VBN
cord-001835-0s7ok4uw	3858	12	protein	protein	NN
cord-001835-0s7ok4uw	3858	13	capsules	capsule	NNS
cord-001835-0s7ok4uw	3858	14	with	with	IN
cord-001835-0s7ok4uw	3858	15	a	a	DT
cord-001835-0s7ok4uw	3858	16	controlled	control	VBN
cord-001835-0s7ok4uw	3858	17	-	-	HYPH
cord-001835-0s7ok4uw	3858	18	release	release	NN
cord-001835-0s7ok4uw	3858	19	function	function	NN
cord-001835-0s7ok4uw	3858	20	by	by	IN
cord-001835-0s7ok4uw	3858	21	introducing	introduce	VBG
cord-001835-0s7ok4uw	3858	22	a	a	DT
cord-001835-0s7ok4uw	3858	23	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	3858	24	bond	bond	NN
cord-001835-0s7ok4uw	3858	25	into	into	IN
cord-001835-0s7ok4uw	3858	26	the	the	DT
cord-001835-0s7ok4uw	3858	27	upper	upper	JJ
cord-001835-0s7ok4uw	3858	28	part	part	NN
cord-001835-0s7ok4uw	3858	29	of	of	IN
cord-001835-0s7ok4uw	3858	30	the	the	DT
cord-001835-0s7ok4uw	3858	31	drug	drug	NN
cord-001835-0s7ok4uw	3858	32	-	-	HYPH
cord-001835-0s7ok4uw	3858	33	binding	bind	VBG
cord-001835-0s7ok4uw	3858	34	cavity	cavity	NN
cord-001835-0s7ok4uw	3858	35	of	of	IN
cord-001835-0s7ok4uw	3858	36	L	L	NNP
cord-001835-0s7ok4uw	3858	37	-	-	HYPH
cord-001835-0s7ok4uw	3858	38	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3858	39	.	.	.
cord-001835-0s7ok4uw	3859	1	The	the	DT
cord-001835-0s7ok4uw	3859	2	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3859	3	concentration	concentration	NN
cord-001835-0s7ok4uw	3859	4	of	of	IN
cord-001835-0s7ok4uw	3859	5	glutathione	glutathione	NN
cord-001835-0s7ok4uw	3859	6	(	(	-LRB-
cord-001835-0s7ok4uw	3859	7	0.510	0.510	CD
cord-001835-0s7ok4uw	3859	8	mM	mm	CD
cord-001835-0s7ok4uw	3859	9	)	)	-RRB-
cord-001835-0s7ok4uw	3859	10	is	be	VBZ
cord-001835-0s7ok4uw	3859	11	known	know	VBN
cord-001835-0s7ok4uw	3859	12	to	to	TO
cord-001835-0s7ok4uw	3859	13	be	be	VB
cord-001835-0s7ok4uw	3859	14	substantially	substantially	RB
cord-001835-0s7ok4uw	3859	15	higher	high	JJR
cord-001835-0s7ok4uw	3859	16	than	than	IN
cord-001835-0s7ok4uw	3859	17	the	the	DT
cord-001835-0s7ok4uw	3859	18	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	3859	19	concentration	concentration	NN
cord-001835-0s7ok4uw	3859	20	(	(	-LRB-
cord-001835-0s7ok4uw	3859	21	2	2	CD
cord-001835-0s7ok4uw	3859	22	mM	mm	CD
cord-001835-0s7ok4uw	3859	23	)	)	-RRB-
cord-001835-0s7ok4uw	3859	24	.	.	.
cord-001835-0s7ok4uw	3860	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	3860	2	,	,	,
cord-001835-0s7ok4uw	3860	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	3860	4	is	be	VBZ
cord-001835-0s7ok4uw	3860	5	expected	expect	VBN
cord-001835-0s7ok4uw	3860	6	that	that	IN
cord-001835-0s7ok4uw	3860	7	in	in	IN
cord-001835-0s7ok4uw	3860	8	the	the	DT
cord-001835-0s7ok4uw	3860	9	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	3860	10	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	3860	11	environment	environment	NN
cord-001835-0s7ok4uw	3860	12	the	the	DT
cord-001835-0s7ok4uw	3860	13	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	3860	14	bonds	bond	NNS
cord-001835-0s7ok4uw	3860	15	in	in	IN
cord-001835-0s7ok4uw	3860	16	the	the	DT
cord-001835-0s7ok4uw	3860	17	protein	protein	NN
cord-001835-0s7ok4uw	3860	18	capsule	capsule	NN
cord-001835-0s7ok4uw	3860	19	remain	remain	VBP
cord-001835-0s7ok4uw	3860	20	stable	stable	JJ
cord-001835-0s7ok4uw	3860	21	,	,	,
cord-001835-0s7ok4uw	3860	22	avoiding	avoid	VBG
cord-001835-0s7ok4uw	3860	23	premature	premature	JJ
cord-001835-0s7ok4uw	3860	24	release	release	NN
cord-001835-0s7ok4uw	3860	25	of	of	IN
cord-001835-0s7ok4uw	3860	26	the	the	DT
cord-001835-0s7ok4uw	3860	27	internal	internal	JJ
cord-001835-0s7ok4uw	3860	28	drugs	drug	NNS
cord-001835-0s7ok4uw	3860	29	during	during	IN
cord-001835-0s7ok4uw	3860	30	circulation	circulation	NN
cord-001835-0s7ok4uw	3860	31	of	of	IN
cord-001835-0s7ok4uw	3860	32	blood	blood	NN
cord-001835-0s7ok4uw	3860	33	,	,	,
cord-001835-0s7ok4uw	3860	34	after	after	IN
cord-001835-0s7ok4uw	3860	35	reaching	reach	VBG
cord-001835-0s7ok4uw	3860	36	the	the	DT
cord-001835-0s7ok4uw	3860	37	target	target	NN
cord-001835-0s7ok4uw	3860	38	cells	cell	NNS
cord-001835-0s7ok4uw	3860	39	,	,	,
cord-001835-0s7ok4uw	3860	40	the	the	DT
cord-001835-0s7ok4uw	3860	41	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	3860	42	bonds	bond	NNS
cord-001835-0s7ok4uw	3860	43	are	be	VBP
cord-001835-0s7ok4uw	3860	44	cleaved	cleave	VBN
cord-001835-0s7ok4uw	3860	45	in	in	IN
cord-001835-0s7ok4uw	3860	46	the	the	DT
cord-001835-0s7ok4uw	3860	47	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	3860	48	redox	redox	NN
cord-001835-0s7ok4uw	3860	49	-	-	HYPH
cord-001835-0s7ok4uw	3860	50	environment	environment	NN
cord-001835-0s7ok4uw	3860	51	,	,	,
cord-001835-0s7ok4uw	3860	52	and	and	CC
cord-001835-0s7ok4uw	3860	53	then	then	RB
cord-001835-0s7ok4uw	3860	54	the	the	DT
cord-001835-0s7ok4uw	3860	55	internal	internal	JJ
cord-001835-0s7ok4uw	3860	56	drugs	drug	NNS
cord-001835-0s7ok4uw	3860	57	are	be	VBP
cord-001835-0s7ok4uw	3860	58	released	release	VBN
cord-001835-0s7ok4uw	3860	59	.	.	.
cord-001835-0s7ok4uw	3861	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3861	2	generated	generate	VBD
cord-001835-0s7ok4uw	3861	3	three	three	CD
cord-001835-0s7ok4uw	3861	4	kinds	kind	NNS
cord-001835-0s7ok4uw	3861	5	of	of	IN
cord-001835-0s7ok4uw	3861	6	protein	protein	NN
cord-001835-0s7ok4uw	3861	7	capsules	capsule	NNS
cord-001835-0s7ok4uw	3861	8	which	which	WDT
cord-001835-0s7ok4uw	3861	9	have	have	VBP
cord-001835-0s7ok4uw	3861	10	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	3861	11	bonds	bond	NNS
cord-001835-0s7ok4uw	3861	12	in	in	IN
cord-001835-0s7ok4uw	3861	13	different	different	JJ
cord-001835-0s7ok4uw	3861	14	positions	position	NNS
cord-001835-0s7ok4uw	3861	15	,	,	,
cord-001835-0s7ok4uw	3861	16	W54C	W54C	NNP
cord-001835-0s7ok4uw	3861	17	/	/	SYM
cord-001835-0s7ok4uw	3861	18	W112C	W112C	NNP
cord-001835-0s7ok4uw	3861	19	,	,	,
cord-001835-0s7ok4uw	3861	20	K58C	K58C	NNP
cord-001835-0s7ok4uw	3861	21	/	/	SYM
cord-001835-0s7ok4uw	3861	22	H111C	H111C	NNP
cord-001835-0s7ok4uw	3861	23	,	,	,
cord-001835-0s7ok4uw	3861	24	K58C	K58C	NNP
cord-001835-0s7ok4uw	3861	25	/	/	SYM
cord-001835-0s7ok4uw	3861	26	W112C	W112C	NNP
cord-001835-0s7ok4uw	3861	27	,	,	,
cord-001835-0s7ok4uw	3861	28	based	base	VBN
cord-001835-0s7ok4uw	3861	29	on	on	IN
cord-001835-0s7ok4uw	3861	30	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	3861	31	structure	structure	NN
cord-001835-0s7ok4uw	3861	32	information	information	NN
cord-001835-0s7ok4uw	3861	33	of	of	IN
cord-001835-0s7ok4uw	3861	34	human	human	JJ
cord-001835-0s7ok4uw	3861	35	L	L	NNP
cord-001835-0s7ok4uw	3861	36	-	-	HYPH
cord-001835-0s7ok4uw	3861	37	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3862	1	(	(	-LRB-
cord-001835-0s7ok4uw	3862	2	PDB	PDB	NNP
cord-001835-0s7ok4uw	3862	3	ID	ID	NNP
cord-001835-0s7ok4uw	3862	4	:	:	:
cord-001835-0s7ok4uw	3862	5	3O2Y	3o2y	CD
cord-001835-0s7ok4uw	3862	6	)	)	-RRB-
cord-001835-0s7ok4uw	3862	7	.	.	.
cord-001835-0s7ok4uw	3863	1	Firstly	firstly	RB
cord-001835-0s7ok4uw	3863	2	,	,	,
cord-001835-0s7ok4uw	3863	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3863	4	performed	perform	VBD
cord-001835-0s7ok4uw	3863	5	circular	circular	JJ
cord-001835-0s7ok4uw	3863	6	dichroism	dichroism	NN
cord-001835-0s7ok4uw	3863	7	(	(	-LRB-
cord-001835-0s7ok4uw	3863	8	CD	CD	NNP
cord-001835-0s7ok4uw	3863	9	)	)	-RRB-
cord-001835-0s7ok4uw	3863	10	measurements	measurement	NNS
cord-001835-0s7ok4uw	3863	11	to	to	TO
cord-001835-0s7ok4uw	3863	12	confirm	confirm	VB
cord-001835-0s7ok4uw	3863	13	the	the	DT
cord-001835-0s7ok4uw	3863	14	structure	structure	NN
cord-001835-0s7ok4uw	3863	15	of	of	IN
cord-001835-0s7ok4uw	3863	16	each	each	DT
cord-001835-0s7ok4uw	3863	17	capsule	capsule	NN
cord-001835-0s7ok4uw	3863	18	.	.	.
cord-001835-0s7ok4uw	3864	1	The	the	DT
cord-001835-0s7ok4uw	3864	2	CD	CD	NNP
cord-001835-0s7ok4uw	3864	3	spectra	spectra	NN
cord-001835-0s7ok4uw	3864	4	of	of	IN
cord-001835-0s7ok4uw	3864	5	three	three	CD
cord-001835-0s7ok4uw	3864	6	protein	protein	NN
cord-001835-0s7ok4uw	3864	7	capsules	capsule	NNS
cord-001835-0s7ok4uw	3864	8	were	be	VBD
cord-001835-0s7ok4uw	3864	9	similar	similar	JJ
cord-001835-0s7ok4uw	3864	10	to	to	IN
cord-001835-0s7ok4uw	3864	11	that	that	DT
cord-001835-0s7ok4uw	3864	12	of	of	IN
cord-001835-0s7ok4uw	3864	13	wild	wild	JJ
cord-001835-0s7ok4uw	3864	14	-	-	HYPH
cord-001835-0s7ok4uw	3864	15	type	type	NN
cord-001835-0s7ok4uw	3864	16	L	l	NN
cord-001835-0s7ok4uw	3864	17	-	-	HYPH
cord-001835-0s7ok4uw	3864	18	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3864	19	in	in	IN
cord-001835-0s7ok4uw	3864	20	the	the	DT
cord-001835-0s7ok4uw	3864	21	far	far	JJ
cord-001835-0s7ok4uw	3864	22	-	-	HYPH
cord-001835-0s7ok4uw	3864	23	UV	uv	NN
cord-001835-0s7ok4uw	3864	24	region	region	NN
cord-001835-0s7ok4uw	3864	25	.	.	.
cord-001835-0s7ok4uw	3865	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	3865	2	,	,	,
cord-001835-0s7ok4uw	3865	3	the	the	DT
cord-001835-0s7ok4uw	3865	4	secondary	secondary	JJ
cord-001835-0s7ok4uw	3865	5	structures	structure	NNS
cord-001835-0s7ok4uw	3865	6	of	of	IN
cord-001835-0s7ok4uw	3865	7	three	three	CD
cord-001835-0s7ok4uw	3865	8	protein	protein	NN
cord-001835-0s7ok4uw	3865	9	capsules	capsule	NNS
cord-001835-0s7ok4uw	3865	10	were	be	VBD
cord-001835-0s7ok4uw	3865	11	not	not	RB
cord-001835-0s7ok4uw	3865	12	changed	change	VBN
cord-001835-0s7ok4uw	3865	13	from	from	IN
cord-001835-0s7ok4uw	3865	14	wild	wild	JJ
cord-001835-0s7ok4uw	3865	15	-	-	HYPH
cord-001835-0s7ok4uw	3865	16	type	type	NN
cord-001835-0s7ok4uw	3865	17	L	l	NN
cord-001835-0s7ok4uw	3865	18	-	-	HYPH
cord-001835-0s7ok4uw	3865	19	PGDS	PGDS	NNP
cord-001835-0s7ok4uw	3865	20	by	by	IN
cord-001835-0s7ok4uw	3865	21	introducing	introduce	VBG
cord-001835-0s7ok4uw	3865	22	the	the	DT
cord-001835-0s7ok4uw	3865	23	mutations	mutation	NNS
cord-001835-0s7ok4uw	3865	24	.	.	.
cord-001835-0s7ok4uw	3866	1	Quantitative	quantitative	JJ
cord-001835-0s7ok4uw	3866	2	analysis	analysis	NN
cord-001835-0s7ok4uw	3866	3	of	of	IN
cord-001835-0s7ok4uw	3866	4	the	the	DT
cord-001835-0s7ok4uw	3866	5	free	free	JJ
cord-001835-0s7ok4uw	3866	6	thiol	thiol	NN
cord-001835-0s7ok4uw	3866	7	group	group	NN
cord-001835-0s7ok4uw	3866	8	in	in	IN
cord-001835-0s7ok4uw	3866	9	the	the	DT
cord-001835-0s7ok4uw	3866	10	protein	protein	NN
cord-001835-0s7ok4uw	3866	11	capsule	capsule	NN
cord-001835-0s7ok4uw	3866	12	by	by	IN
cord-001835-0s7ok4uw	3866	13	DTNB	DTNB	NNP
cord-001835-0s7ok4uw	3866	14	assay	assay	NN
cord-001835-0s7ok4uw	3866	15	revealed	reveal	VBD
cord-001835-0s7ok4uw	3866	16	that	that	IN
cord-001835-0s7ok4uw	3866	17	the	the	DT
cord-001835-0s7ok4uw	3866	18	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	3866	19	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	3866	20	bond	bond	NN
cord-001835-0s7ok4uw	3866	21	was	be	VBD
cord-001835-0s7ok4uw	3866	22	formed	form	VBN
cord-001835-0s7ok4uw	3866	23	by	by	IN
cord-001835-0s7ok4uw	3866	24	H2O2-induced	H2O2-induced	NNP
cord-001835-0s7ok4uw	3866	25	oxidation	oxidation	NN
cord-001835-0s7ok4uw	3866	26	and	and	CC
cord-001835-0s7ok4uw	3866	27	cleaved	cleave	VBN
cord-001835-0s7ok4uw	3866	28	by	by	IN
cord-001835-0s7ok4uw	3866	29	dithiothreitol	dithiothreitol	NNP
cord-001835-0s7ok4uw	3866	30	-	-	HYPH
cord-001835-0s7ok4uw	3866	31	induced	induce	VBN
cord-001835-0s7ok4uw	3866	32	reduction	reduction	NN
cord-001835-0s7ok4uw	3866	33	.	.	.
cord-001835-0s7ok4uw	3867	1	In	in	IN
cord-001835-0s7ok4uw	3867	2	addition	addition	NN
cord-001835-0s7ok4uw	3867	3	,	,	,
cord-001835-0s7ok4uw	3867	4	to	to	TO
cord-001835-0s7ok4uw	3867	5	investigate	investigate	VB
cord-001835-0s7ok4uw	3867	6	the	the	DT
cord-001835-0s7ok4uw	3867	7	solubility	solubility	NN
cord-001835-0s7ok4uw	3867	8	of	of	IN
cord-001835-0s7ok4uw	3867	9	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3867	10	in	in	IN
cord-001835-0s7ok4uw	3867	11	the	the	DT
cord-001835-0s7ok4uw	3867	12	presence	presence	NN
cord-001835-0s7ok4uw	3867	13	of	of	IN
cord-001835-0s7ok4uw	3867	14	protein	protein	NN
cord-001835-0s7ok4uw	3867	15	capsules	capsule	NNS
cord-001835-0s7ok4uw	3867	16	,	,	,
cord-001835-0s7ok4uw	3867	17	we	-PRON-	PRP
cord-001835-0s7ok4uw	3867	18	mixed	mix	VBD
cord-001835-0s7ok4uw	3867	19	the	the	DT
cord-001835-0s7ok4uw	3867	20	protein	protein	NN
cord-001835-0s7ok4uw	3867	21	capsule	capsule	NN
cord-001835-0s7ok4uw	3867	22	of	of	IN
cord-001835-0s7ok4uw	3867	23	reduced	reduce	VBN
cord-001835-0s7ok4uw	3867	24	-	-	HYPH
cord-001835-0s7ok4uw	3867	25	form	form	NN
cord-001835-0s7ok4uw	3867	26	with	with	IN
cord-001835-0s7ok4uw	3867	27	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3867	28	suspension	suspension	NN
cord-001835-0s7ok4uw	3867	29	,	,	,
cord-001835-0s7ok4uw	3867	30	and	and	CC
cord-001835-0s7ok4uw	3867	31	stirred	stir	VBD
cord-001835-0s7ok4uw	3867	32	at	at	IN
cord-001835-0s7ok4uw	3867	33	37	37	CD
cord-001835-0s7ok4uw	3867	34	C	c	NN
cord-001835-0s7ok4uw	3867	35	for	for	IN
cord-001835-0s7ok4uw	3867	36	48	48	CD
cord-001835-0s7ok4uw	3867	37	hours	hour	NNS
cord-001835-0s7ok4uw	3867	38	.	.	.
cord-001835-0s7ok4uw	3868	1	The	the	DT
cord-001835-0s7ok4uw	3868	2	resulting	result	VBG
cord-001835-0s7ok4uw	3868	3	concentrations	concentration	NNS
cord-001835-0s7ok4uw	3868	4	of	of	IN
cord-001835-0s7ok4uw	3868	5	SN-38	SN-38	NNP
cord-001835-0s7ok4uw	3868	6	in	in	IN
cord-001835-0s7ok4uw	3868	7	PBS	PBS	NNP
cord-001835-0s7ok4uw	3868	8	with	with	IN
cord-001835-0s7ok4uw	3869	1	1	1	LS
cord-001835-0s7ok4uw	3869	2	mM	mm	CD
cord-001835-0s7ok4uw	3869	3	W54C	W54C	NNP
cord-001835-0s7ok4uw	3869	4	/	/	SYM
cord-001835-0s7ok4uw	3869	5	W112C	W112C	NNP
cord-001835-0s7ok4uw	3869	6	,	,	,
cord-001835-0s7ok4uw	3869	7	K58C	K58C	NNP
cord-001835-0s7ok4uw	3869	8	/	/	SYM
cord-001835-0s7ok4uw	3869	9	H111C	H111C	NNP
cord-001835-0s7ok4uw	3869	10	,	,	,
cord-001835-0s7ok4uw	3869	11	and	and	CC
cord-001835-0s7ok4uw	3869	12	K58C	K58C	NNP
cord-001835-0s7ok4uw	3869	13	/	/	SYM
cord-001835-0s7ok4uw	3869	14	W112C	W112C	NNS
cord-001835-0s7ok4uw	3869	15	were	be	VBD
cord-001835-0s7ok4uw	3869	16	374	374	CD
cord-001835-0s7ok4uw	3869	17	mM	mm	CD
cord-001835-0s7ok4uw	3869	18	,	,	,
cord-001835-0s7ok4uw	3869	19	194	194	CD
cord-001835-0s7ok4uw	3869	20	mM	mm	CD
cord-001835-0s7ok4uw	3869	21	,	,	,
cord-001835-0s7ok4uw	3869	22	and	and	CC
cord-001835-0s7ok4uw	3869	23	349	349	CD
cord-001835-0s7ok4uw	3869	24	mM	mm	CD
cord-001835-0s7ok4uw	3869	25	,	,	,
cord-001835-0s7ok4uw	3869	26	respectively	respectively	RB
cord-001835-0s7ok4uw	3869	27	.	.	.
cord-001835-0s7ok4uw	3870	1	These	these	DT
cord-001835-0s7ok4uw	3870	2	values	value	NNS
cord-001835-0s7ok4uw	3870	3	were	be	VBD
cord-001835-0s7ok4uw	3870	4	approximately	approximately	RB
cord-001835-0s7ok4uw	3870	5	200-fold	200-fold	CD
cord-001835-0s7ok4uw	3870	6	higher	high	JJR
cord-001835-0s7ok4uw	3870	7	than	than	IN
cord-001835-0s7ok4uw	3870	8	without	without	IN
cord-001835-0s7ok4uw	3870	9	protein	protein	NN
cord-001835-0s7ok4uw	3870	10	capsules	capsule	NNS
cord-001835-0s7ok4uw	3870	11	.	.	.
cord-001835-0s7ok4uw	3871	1	SDS	SDS	NNP
cord-001835-0s7ok4uw	3871	2	-	-	HYPH
cord-001835-0s7ok4uw	3871	3	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	3871	4	analysis	analysis	NN
cord-001835-0s7ok4uw	3871	5	showed	show	VBD
cord-001835-0s7ok4uw	3871	6	that	that	IN
cord-001835-0s7ok4uw	3871	7	the	the	DT
cord-001835-0s7ok4uw	3871	8	bond	bond	NN
cord-001835-0s7ok4uw	3871	9	formation	formation	NN
cord-001835-0s7ok4uw	3871	10	decreased	decrease	VBD
cord-001835-0s7ok4uw	3871	11	in	in	IN
cord-001835-0s7ok4uw	3871	12	a	a	DT
cord-001835-0s7ok4uw	3871	13	time	time	NN
cord-001835-0s7ok4uw	3871	14	-	-	HYPH
cord-001835-0s7ok4uw	3871	15	dependent	dependent	JJ
cord-001835-0s7ok4uw	3871	16	manner	manner	NN
cord-001835-0s7ok4uw	3871	17	,	,	,
cord-001835-0s7ok4uw	3871	18	and	and	CC
cord-001835-0s7ok4uw	3871	19	that	that	IN
cord-001835-0s7ok4uw	3871	20	new	new	JJ
cord-001835-0s7ok4uw	3871	21	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	3871	22	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	3871	23	bond	bond	NN
cord-001835-0s7ok4uw	3871	24	was	be	VBD
cord-001835-0s7ok4uw	3871	25	not	not	RB
cord-001835-0s7ok4uw	3871	26	formed	form	VBN
cord-001835-0s7ok4uw	3871	27	in	in	IN
cord-001835-0s7ok4uw	3871	28	the	the	DT
cord-001835-0s7ok4uw	3871	29	protein	protein	NN
cord-001835-0s7ok4uw	3871	30	capsules	capsule	NNS
cord-001835-0s7ok4uw	3871	31	after	after	IN
cord-001835-0s7ok4uw	3871	32	48	48	CD
cord-001835-0s7ok4uw	3871	33	hours	hour	NNS
cord-001835-0s7ok4uw	3871	34	'	'	POS
cord-001835-0s7ok4uw	3871	35	incubation	incubation	NN
cord-001835-0s7ok4uw	3871	36	.	.	.
cord-001835-0s7ok4uw	3872	1	From	from	IN
cord-001835-0s7ok4uw	3872	2	the	the	DT
cord-001835-0s7ok4uw	3872	3	above	above	JJ
cord-001835-0s7ok4uw	3872	4	,	,	,
cord-001835-0s7ok4uw	3872	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3872	6	succeeded	succeed	VBD
cord-001835-0s7ok4uw	3872	7	in	in	IN
cord-001835-0s7ok4uw	3872	8	generating	generate	VBG
cord-001835-0s7ok4uw	3872	9	drug	drug	NN
cord-001835-0s7ok4uw	3872	10	delivery	delivery	NN
cord-001835-0s7ok4uw	3872	11	vehicles	vehicle	NNS
cord-001835-0s7ok4uw	3872	12	possessing	possess	VBG
cord-001835-0s7ok4uw	3872	13	openable	openable	JJ
cord-001835-0s7ok4uw	3872	14	and	and	CC
cord-001835-0s7ok4uw	3872	15	closable	closable	JJ
cord-001835-0s7ok4uw	3872	16	lids	lid	NNS
cord-001835-0s7ok4uw	3872	17	that	that	WDT
cord-001835-0s7ok4uw	3872	18	are	be	VBP
cord-001835-0s7ok4uw	3872	19	responsive	responsive	JJ
cord-001835-0s7ok4uw	3872	20	in	in	IN
cord-001835-0s7ok4uw	3872	21	an	an	DT
cord-001835-0s7ok4uw	3872	22	oxidation	oxidation	NN
cord-001835-0s7ok4uw	3872	23	-	-	HYPH
cord-001835-0s7ok4uw	3872	24	reduction	reduction	NN
cord-001835-0s7ok4uw	3872	25	environment	environment	NN
cord-001835-0s7ok4uw	3872	26	.	.	.
cord-001835-0s7ok4uw	3873	1	Takaaki	Takaaki	NNP
cord-001835-0s7ok4uw	3873	2	Miyamoto	Miyamoto	NNP
cord-001835-0s7ok4uw	3873	3	1	1	CD
cord-001835-0s7ok4uw	3873	4	,	,	,
cord-001835-0s7ok4uw	3873	5	Mai	Mai	NNP
cord-001835-0s7ok4uw	3873	6	Kuribayashi	Kuribayashi	NNP
cord-001835-0s7ok4uw	3873	7	1	1	CD
cord-001835-0s7ok4uw	3873	8	,	,	,
cord-001835-0s7ok4uw	3873	9	Satoshi	Satoshi	NNP
cord-001835-0s7ok4uw	3873	10	Nagao	Nagao	NNP
cord-001835-0s7ok4uw	3873	11	1	1	CD
cord-001835-0s7ok4uw	3873	12	,	,	,
cord-001835-0s7ok4uw	3873	13	Yasuhito	Yasuhito	NNP
cord-001835-0s7ok4uw	3873	14	Shomura	Shomura	NNP
cord-001835-0s7ok4uw	3873	15	2	2	CD
cord-001835-0s7ok4uw	3873	16	,	,	,
cord-001835-0s7ok4uw	3873	17	Yoshiki	Yoshiki	NNP
cord-001835-0s7ok4uw	3873	18	Higuchi	Higuchi	NNP
cord-001835-0s7ok4uw	3873	19	3,4	3,4	CD
cord-001835-0s7ok4uw	3873	20	,	,	,
cord-001835-0s7ok4uw	3873	21	Shun	Shun	NNP
cord-001835-0s7ok4uw	3873	22	Hirota	Hirota	NNP
cord-001835-0s7ok4uw	3873	23	1	1	CD
cord-001835-0s7ok4uw	3873	24	1	1	CD
cord-001835-0s7ok4uw	3873	25	Graduate	Graduate	NNP
cord-001835-0s7ok4uw	3873	26	School	School	NNP
cord-001835-0s7ok4uw	3873	27	of	of	IN
cord-001835-0s7ok4uw	3873	28	Materials	Materials	NNP
cord-001835-0s7ok4uw	3873	29	Science	Science	NNP
cord-001835-0s7ok4uw	3873	30	,	,	,
cord-001835-0s7ok4uw	3873	31	Nara	Nara	NNP
cord-001835-0s7ok4uw	3873	32	Institutte	Institutte	NNP
cord-001835-0s7ok4uw	3873	33	of	of	IN
cord-001835-0s7ok4uw	3873	34	Science	Science	NNP
cord-001835-0s7ok4uw	3873	35	and	and	CC
cord-001835-0s7ok4uw	3873	36	Technology	Technology	NNP
cord-001835-0s7ok4uw	3873	37	,	,	,
cord-001835-0s7ok4uw	3873	38	2	2	CD
cord-001835-0s7ok4uw	3873	39	Graduate	Graduate	NNP
cord-001835-0s7ok4uw	3873	40	School	School	NNP
cord-001835-0s7ok4uw	3873	41	of	of	IN
cord-001835-0s7ok4uw	3873	42	Science	Science	NNP
cord-001835-0s7ok4uw	3873	43	and	and	CC
cord-001835-0s7ok4uw	3873	44	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	3873	45	,	,	,
cord-001835-0s7ok4uw	3873	46	Ibaraki	Ibaraki	NNP
cord-001835-0s7ok4uw	3873	47	University	University	NNP
cord-001835-0s7ok4uw	3873	48	,	,	,
cord-001835-0s7ok4uw	3873	49	3	3	CD
cord-001835-0s7ok4uw	3873	50	Department	Department	NNP
cord-001835-0s7ok4uw	3873	51	of	of	IN
cord-001835-0s7ok4uw	3873	52	Life	Life	NNP
cord-001835-0s7ok4uw	3873	53	Science	Science	NNP
cord-001835-0s7ok4uw	3873	54	,	,	,
cord-001835-0s7ok4uw	3873	55	Graduate	Graduate	NNP
cord-001835-0s7ok4uw	3873	56	School	School	NNP
cord-001835-0s7ok4uw	3873	57	of	of	IN
cord-001835-0s7ok4uw	3873	58	Life	Life	NNP
cord-001835-0s7ok4uw	3873	59	Science	Science	NNP
cord-001835-0s7ok4uw	3873	60	,	,	,
cord-001835-0s7ok4uw	3873	61	University	University	NNP
cord-001835-0s7ok4uw	3873	62	of	of	IN
cord-001835-0s7ok4uw	3873	63	Hyogo	Hyogo	NNP
cord-001835-0s7ok4uw	3873	64	,	,	,
cord-001835-0s7ok4uw	3873	65	4	4	CD
cord-001835-0s7ok4uw	3873	66	 	 	_SP
cord-001835-0s7ok4uw	3873	67	Domain	Domain	NNP
cord-001835-0s7ok4uw	3873	68	swapping	swapping	NN
cord-001835-0s7ok4uw	3873	69	has	have	VBZ
cord-001835-0s7ok4uw	3873	70	been	be	VBN
cord-001835-0s7ok4uw	3873	71	of	of	IN
cord-001835-0s7ok4uw	3873	72	interest	interest	NN
cord-001835-0s7ok4uw	3873	73	as	as	IN
cord-001835-0s7ok4uw	3873	74	a	a	DT
cord-001835-0s7ok4uw	3873	75	mechanism	mechanism	NN
cord-001835-0s7ok4uw	3873	76	of	of	IN
cord-001835-0s7ok4uw	3873	77	protein	protein	NN
cord-001835-0s7ok4uw	3873	78	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	3873	79	,	,	,
cord-001835-0s7ok4uw	3873	80	where	where	WRB
cord-001835-0s7ok4uw	3873	81	a	a	DT
cord-001835-0s7ok4uw	3873	82	secondary	secondary	JJ
cord-001835-0s7ok4uw	3873	83	structural	structural	JJ
cord-001835-0s7ok4uw	3873	84	region	region	NN
cord-001835-0s7ok4uw	3873	85	or	or	CC
cord-001835-0s7ok4uw	3873	86	a	a	DT
cord-001835-0s7ok4uw	3873	87	domain	domain	NN
cord-001835-0s7ok4uw	3873	88	of	of	IN
cord-001835-0s7ok4uw	3873	89	one	one	CD
cord-001835-0s7ok4uw	3873	90	protein	protein	NN
cord-001835-0s7ok4uw	3873	91	molecule	molecule	NN
cord-001835-0s7ok4uw	3873	92	is	be	VBZ
cord-001835-0s7ok4uw	3873	93	replaced	replace	VBN
cord-001835-0s7ok4uw	3873	94	with	with	IN
cord-001835-0s7ok4uw	3873	95	the	the	DT
cord-001835-0s7ok4uw	3873	96	corresponding	correspond	VBG
cord-001835-0s7ok4uw	3873	97	region	region	NN
cord-001835-0s7ok4uw	3873	98	or	or	CC
cord-001835-0s7ok4uw	3873	99	domain	domain	NN
cord-001835-0s7ok4uw	3873	100	of	of	IN
cord-001835-0s7ok4uw	3873	101	another	another	DT
cord-001835-0s7ok4uw	3873	102	protein	protein	NN
cord-001835-0s7ok4uw	3873	103	molecule	molecule	NN
cord-001835-0s7ok4uw	3873	104	.	.	.
cord-001835-0s7ok4uw	3874	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3874	2	have	have	VBP
cord-001835-0s7ok4uw	3874	3	previously	previously	RB
cord-001835-0s7ok4uw	3874	4	shown	show	VBN
cord-001835-0s7ok4uw	3874	5	that	that	IN
cord-001835-0s7ok4uw	3874	6	c	c	NN
cord-001835-0s7ok4uw	3874	7	-	-	HYPH
cord-001835-0s7ok4uw	3874	8	type	type	NN
cord-001835-0s7ok4uw	3874	9	cytochromes	cytochrome	NNS
cord-001835-0s7ok4uw	3874	10	and	and	CC
cord-001835-0s7ok4uw	3874	11	myoglobin	myoglobin	NN
cord-001835-0s7ok4uw	3874	12	form	form	NN
cord-001835-0s7ok4uw	3874	13	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	3874	14	by	by	IN
cord-001835-0s7ok4uw	3874	15	domain	domain	NN
cord-001835-0s7ok4uw	3874	16	swapping.1,2	swapping.1,2	NNS
cord-001835-0s7ok4uw	3875	1	In	in	IN
cord-001835-0s7ok4uw	3875	2	this	this	DT
cord-001835-0s7ok4uw	3875	3	study	study	NN
cord-001835-0s7ok4uw	3875	4	,	,	,
cord-001835-0s7ok4uw	3875	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3875	6	show	show	VBP
cord-001835-0s7ok4uw	3875	7	that	that	IN
cord-001835-0s7ok4uw	3875	8	a	a	DT
cord-001835-0s7ok4uw	3875	9	four	four	CD
cord-001835-0s7ok4uw	3875	10	-	-	HYPH
cord-001835-0s7ok4uw	3875	11	helix	helix	NN
cord-001835-0s7ok4uw	3875	12	bundle	bundle	NN
cord-001835-0s7ok4uw	3875	13	protein	protein	NN
cord-001835-0s7ok4uw	3875	14	cyt	cyt	NN
cord-001835-0s7ok4uw	3875	15	cb562	cb562	NNP
cord-001835-0s7ok4uw	3875	16	,	,	,
cord-001835-0s7ok4uw	3875	17	in	in	IN
cord-001835-0s7ok4uw	3875	18	which	which	WDT
cord-001835-0s7ok4uw	3875	19	the	the	DT
cord-001835-0s7ok4uw	3875	20	heme	heme	NN
cord-001835-0s7ok4uw	3875	21	of	of	IN
cord-001835-0s7ok4uw	3875	22	cyt	cyt	NNP
cord-001835-0s7ok4uw	3875	23	b562	b562	NNP
cord-001835-0s7ok4uw	3875	24	is	be	VBZ
cord-001835-0s7ok4uw	3875	25	attached	attach	VBN
cord-001835-0s7ok4uw	3875	26	to	to	IN
cord-001835-0s7ok4uw	3875	27	the	the	DT
cord-001835-0s7ok4uw	3875	28	protein	protein	NN
cord-001835-0s7ok4uw	3875	29	moiety	moiety	NN
cord-001835-0s7ok4uw	3875	30	by	by	IN
cord-001835-0s7ok4uw	3875	31	insertion	insertion	NN
cord-001835-0s7ok4uw	3875	32	of	of	IN
cord-001835-0s7ok4uw	3875	33	two	two	CD
cord-001835-0s7ok4uw	3875	34	Cys	Cys	NNP
cord-001835-0s7ok4uw	3875	35	residues	residue	NNS
cord-001835-0s7ok4uw	3875	36	,	,	,
cord-001835-0s7ok4uw	3875	37	forms	form	VBZ
cord-001835-0s7ok4uw	3875	38	a	a	DT
cord-001835-0s7ok4uw	3875	39	domain	domain	NN
cord-001835-0s7ok4uw	3875	40	-	-	HYPH
cord-001835-0s7ok4uw	3875	41	swapped	swap	VBN
cord-001835-0s7ok4uw	3875	42	dimer	dimer	NN
cord-001835-0s7ok4uw	3875	43	.	.	.
cord-001835-0s7ok4uw	3876	1	Dimeric	Dimeric	NNP
cord-001835-0s7ok4uw	3876	2	cyt	cyt	VBP
cord-001835-0s7ok4uw	3876	3	cb562	cb562	PRP
cord-001835-0s7ok4uw	3876	4	was	be	VBD
cord-001835-0s7ok4uw	3876	5	more	more	RBR
cord-001835-0s7ok4uw	3876	6	stable	stable	JJ
cord-001835-0s7ok4uw	3876	7	than	than	IN
cord-001835-0s7ok4uw	3876	8	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	3876	9	cyt	cyt	NN
cord-001835-0s7ok4uw	3876	10	b562	b562	NN
cord-001835-0s7ok4uw	3876	11	at	at	IN
cord-001835-0s7ok4uw	3876	12	48C	48c	CD
cord-001835-0s7ok4uw	3876	13	,	,	,
cord-001835-0s7ok4uw	3876	14	showing	show	VBG
cord-001835-0s7ok4uw	3876	15	that	that	DT
cord-001835-0s7ok4uw	3876	16	attachment	attachment	NN
cord-001835-0s7ok4uw	3876	17	of	of	IN
cord-001835-0s7ok4uw	3876	18	the	the	DT
cord-001835-0s7ok4uw	3876	19	heme	heme	NN
cord-001835-0s7ok4uw	3876	20	to	to	IN
cord-001835-0s7ok4uw	3876	21	the	the	DT
cord-001835-0s7ok4uw	3876	22	protein	protein	NN
cord-001835-0s7ok4uw	3876	23	moiety	moiety	NN
cord-001835-0s7ok4uw	3876	24	stabilizes	stabilize	VBZ
cord-001835-0s7ok4uw	3876	25	the	the	DT
cord-001835-0s7ok4uw	3876	26	domain	domain	NN
cord-001835-0s7ok4uw	3876	27	-	-	HYPH
cord-001835-0s7ok4uw	3876	28	swapped	swap	VBN
cord-001835-0s7ok4uw	3876	29	structure	structure	NN
cord-001835-0s7ok4uw	3876	30	.	.	.
cord-001835-0s7ok4uw	3877	1	Absorption	absorption	NN
cord-001835-0s7ok4uw	3877	2	and	and	CC
cord-001835-0s7ok4uw	3877	3	CD	cd	NN
cord-001835-0s7ok4uw	3877	4	spectra	spectrum	NNS
cord-001835-0s7ok4uw	3877	5	of	of	IN
cord-001835-0s7ok4uw	3877	6	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	3877	7	cyt	cyt	NN
cord-001835-0s7ok4uw	3877	8	cb562	cb562	PRP
cord-001835-0s7ok4uw	3877	9	were	be	VBD
cord-001835-0s7ok4uw	3877	10	similar	similar	JJ
cord-001835-0s7ok4uw	3877	11	to	to	IN
cord-001835-0s7ok4uw	3877	12	the	the	DT
cord-001835-0s7ok4uw	3877	13	corresponding	correspond	VBG
cord-001835-0s7ok4uw	3877	14	spectra	spectra	NN
cord-001835-0s7ok4uw	3877	15	of	of	IN
cord-001835-0s7ok4uw	3877	16	the	the	DT
cord-001835-0s7ok4uw	3877	17	monomer	monomer	NN
cord-001835-0s7ok4uw	3877	18	,	,	,
cord-001835-0s7ok4uw	3877	19	showing	show	VBG
cord-001835-0s7ok4uw	3877	20	that	that	IN
cord-001835-0s7ok4uw	3877	21	the	the	DT
cord-001835-0s7ok4uw	3877	22	active	active	JJ
cord-001835-0s7ok4uw	3877	23	site	site	NN
cord-001835-0s7ok4uw	3877	24	and	and	CC
cord-001835-0s7ok4uw	3877	25	secondary	secondary	JJ
cord-001835-0s7ok4uw	3877	26	structures	structure	NNS
cord-001835-0s7ok4uw	3877	27	were	be	VBD
cord-001835-0s7ok4uw	3877	28	similar	similar	JJ
cord-001835-0s7ok4uw	3877	29	between	between	IN
cord-001835-0s7ok4uw	3877	30	the	the	DT
cord-001835-0s7ok4uw	3877	31	dimer	dimer	NN
cord-001835-0s7ok4uw	3877	32	and	and	CC
cord-001835-0s7ok4uw	3877	33	monomer	monomer	NN
cord-001835-0s7ok4uw	3877	34	.	.	.
cord-001835-0s7ok4uw	3878	1	The	the	DT
cord-001835-0s7ok4uw	3878	2	redox	redox	JJ
cord-001835-0s7ok4uw	3878	3	potential	potential	NN
cord-001835-0s7ok4uw	3878	4	of	of	IN
cord-001835-0s7ok4uw	3878	5	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	3878	6	cyt	cyt	NN
cord-001835-0s7ok4uw	3878	7	cb562	cb562	NNP
cord-001835-0s7ok4uw	3878	8	was	be	VBD
cord-001835-0s7ok4uw	3878	9	also	also	RB
cord-001835-0s7ok4uw	3878	10	similar	similar	JJ
cord-001835-0s7ok4uw	3878	11	to	to	IN
cord-001835-0s7ok4uw	3878	12	that	that	DT
cord-001835-0s7ok4uw	3878	13	of	of	IN
cord-001835-0s7ok4uw	3878	14	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3878	15	monomer	monomer	NN
cord-001835-0s7ok4uw	3878	16	.	.	.
cord-001835-0s7ok4uw	3879	1	The	the	DT
cord-001835-0s7ok4uw	3879	2	dissociation	dissociation	NN
cord-001835-0s7ok4uw	3879	3	temperature	temperature	NN
cord-001835-0s7ok4uw	3879	4	of	of	IN
cord-001835-0s7ok4uw	3879	5	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	3879	6	cyt	cyt	NN
cord-001835-0s7ok4uw	3879	7	cb562	cb562	NNP
cord-001835-0s7ok4uw	3879	8	was	be	VBD
cord-001835-0s7ok4uw	3879	9	508C	508c	CD
cord-001835-0s7ok4uw	3879	10	,	,	,
cord-001835-0s7ok4uw	3879	11	and	and	CC
cord-001835-0s7ok4uw	3879	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3879	13	DH	dh	NN
cord-001835-0s7ok4uw	3879	14	on	on	IN
cord-001835-0s7ok4uw	3879	15	dissociation	dissociation	NN
cord-001835-0s7ok4uw	3879	16	to	to	IN
cord-001835-0s7ok4uw	3879	17	monomers	monomer	NNS
cord-001835-0s7ok4uw	3879	18	was	be	VBD
cord-001835-0s7ok4uw	3879	19	213.3	213.3	CD
cord-001835-0s7ok4uw	3879	20	kcal	kcal	NNP
cord-001835-0s7ok4uw	3879	21	/	/	SYM
cord-001835-0s7ok4uw	3879	22	mol	mol	NN
cord-001835-0s7ok4uw	3879	23	(	(	-LRB-
cord-001835-0s7ok4uw	3879	24	per	per	IN
cord-001835-0s7ok4uw	3879	25	dimer	dimer	NN
cord-001835-0s7ok4uw	3879	26	)	)	-RRB-
cord-001835-0s7ok4uw	3879	27	.	.	.
cord-001835-0s7ok4uw	3880	1	According	accord	VBG
cord-001835-0s7ok4uw	3880	2	to	to	IN
cord-001835-0s7ok4uw	3880	3	X	x	NN
cord-001835-0s7ok4uw	3880	4	-	-	NN
cord-001835-0s7ok4uw	3880	5	ray	ray	JJ
cord-001835-0s7ok4uw	3880	6	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	3880	7	analysis	analysis	NN
cord-001835-0s7ok4uw	3880	8	,	,	,
cord-001835-0s7ok4uw	3880	9	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	3880	10	cyt	cyt	NN
cord-001835-0s7ok4uw	3880	11	cb562	cb562	NNP
cord-001835-0s7ok4uw	3880	12	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	3880	13	a	a	DT
cord-001835-0s7ok4uw	3880	14	domain	domain	NN
cord-001835-0s7ok4uw	3880	15	-	-	HYPH
cord-001835-0s7ok4uw	3880	16	swapped	swap	VBN
cord-001835-0s7ok4uw	3880	17	structure	structure	NN
cord-001835-0s7ok4uw	3880	18	,	,	,
cord-001835-0s7ok4uw	3880	19	where	where	WRB
cord-001835-0s7ok4uw	3880	20	the	the	DT
cord-001835-0s7ok4uw	3880	21	two	two	CD
cord-001835-0s7ok4uw	3880	22	helices	helix	NNS
cord-001835-0s7ok4uw	3880	23	in	in	IN
cord-001835-0s7ok4uw	3880	24	the	the	DT
cord-001835-0s7ok4uw	3880	25	N	n	CD
cord-001835-0s7ok4uw	3880	26	-	-	HYPH
cord-001835-0s7ok4uw	3880	27	terminal	terminal	NN
cord-001835-0s7ok4uw	3880	28	region	region	NN
cord-001835-0s7ok4uw	3880	29	(	(	-LRB-
cord-001835-0s7ok4uw	3880	30	helices	helix	NNS
cord-001835-0s7ok4uw	3880	31	1	1	CD
cord-001835-0s7ok4uw	3880	32	and	and	CC
cord-001835-0s7ok4uw	3880	33	2	2	CD
cord-001835-0s7ok4uw	3880	34	)	)	-RRB-
cord-001835-0s7ok4uw	3880	35	in	in	IN
cord-001835-0s7ok4uw	3880	36	a	a	DT
cord-001835-0s7ok4uw	3880	37	protomer	protomer	NN
cord-001835-0s7ok4uw	3880	38	and	and	CC
cord-001835-0s7ok4uw	3880	39	the	the	DT
cord-001835-0s7ok4uw	3880	40	other	other	JJ
cord-001835-0s7ok4uw	3880	41	two	two	CD
cord-001835-0s7ok4uw	3880	42	helices	helix	NNS
cord-001835-0s7ok4uw	3880	43	in	in	IN
cord-001835-0s7ok4uw	3880	44	the	the	DT
cord-001835-0s7ok4uw	3880	45	C	C	NNP
cord-001835-0s7ok4uw	3880	46	-	-	HYPH
cord-001835-0s7ok4uw	3880	47	terminal	terminal	NN
cord-001835-0s7ok4uw	3880	48	region	region	NN
cord-001835-0s7ok4uw	3880	49	(	(	-LRB-
cord-001835-0s7ok4uw	3880	50	helices	helix	NNS
cord-001835-0s7ok4uw	3880	51	3	3	CD
cord-001835-0s7ok4uw	3880	52	and	and	CC
cord-001835-0s7ok4uw	3880	53	4	4	CD
cord-001835-0s7ok4uw	3880	54	)	)	-RRB-
cord-001835-0s7ok4uw	3880	55	of	of	IN
cord-001835-0s7ok4uw	3880	56	the	the	DT
cord-001835-0s7ok4uw	3880	57	other	other	JJ
cord-001835-0s7ok4uw	3880	58	protomer	protomer	NN
cord-001835-0s7ok4uw	3880	59	interacted	interact	VBN
cord-001835-0s7ok4uw	3880	60	between	between	IN
cord-001835-0s7ok4uw	3880	61	each	each	DT
cord-001835-0s7ok4uw	3880	62	other	other	JJ
cord-001835-0s7ok4uw	3880	63	.	.	.
cord-001835-0s7ok4uw	3881	1	The	the	DT
cord-001835-0s7ok4uw	3881	2	heme	heme	NN
cord-001835-0s7ok4uw	3881	3	coordination	coordination	NN
cord-001835-0s7ok4uw	3881	4	structure	structure	NN
cord-001835-0s7ok4uw	3881	5	of	of	IN
cord-001835-0s7ok4uw	3881	6	the	the	DT
cord-001835-0s7ok4uw	3881	7	dimer	dimer	NN
cord-001835-0s7ok4uw	3881	8	was	be	VBD
cord-001835-0s7ok4uw	3881	9	similar	similar	JJ
cord-001835-0s7ok4uw	3881	10	to	to	IN
cord-001835-0s7ok4uw	3881	11	that	that	DT
cord-001835-0s7ok4uw	3881	12	of	of	IN
cord-001835-0s7ok4uw	3881	13	the	the	DT
cord-001835-0s7ok4uw	3881	14	monomer	monomer	NN
cord-001835-0s7ok4uw	3881	15	.	.	.
cord-001835-0s7ok4uw	3882	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3882	2	have	have	VBP
cord-001835-0s7ok4uw	3882	3	previously	previously	RB
cord-001835-0s7ok4uw	3882	4	shown	show	VBN
cord-001835-0s7ok4uw	3882	5	that	that	IN
cord-001835-0s7ok4uw	3882	6	domain	domain	NN
cord-001835-0s7ok4uw	3882	7	-	-	HYPH
cord-001835-0s7ok4uw	3882	8	swapped	swap	VBN
cord-001835-0s7ok4uw	3882	9	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	3882	10	of	of	IN
cord-001835-0s7ok4uw	3882	11	horse	horse	NN
cord-001835-0s7ok4uw	3882	12	cyt	cyt	NN
cord-001835-0s7ok4uw	3882	13	c	c	NN
cord-001835-0s7ok4uw	3882	14	form	form	NN
cord-001835-0s7ok4uw	3882	15	through	through	IN
cord-001835-0s7ok4uw	3882	16	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	3882	17	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3882	18	interaction	interaction	NN
cord-001835-0s7ok4uw	3882	19	between	between	IN
cord-001835-0s7ok4uw	3882	20	the	the	DT
cord-001835-0s7ok4uw	3882	21	N	N	NNP
cord-001835-0s7ok4uw	3882	22	-	-	HYPH
cord-001835-0s7ok4uw	3882	23	and	and	CC
cord-001835-0s7ok4uw	3882	24	C	C	NNP
cord-001835-0s7ok4uw	3882	25	-	-	HYPH
cord-001835-0s7ok4uw	3882	26	terminal	terminal	NN
cord-001835-0s7ok4uw	3882	27	a	a	DT
cord-001835-0s7ok4uw	3882	28	-	-	:
cord-001835-0s7ok4uw	3882	29	helices	helix	NNS
cord-001835-0s7ok4uw	3882	30	at	at	IN
cord-001835-0s7ok4uw	3882	31	the	the	DT
cord-001835-0s7ok4uw	3882	32	early	early	JJ
cord-001835-0s7ok4uw	3882	33	stage	stage	NN
cord-001835-0s7ok4uw	3882	34	of	of	IN
cord-001835-0s7ok4uw	3882	35	folding.3	folding.3	NN
cord-001835-0s7ok4uw	3883	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3883	2	has	have	VBZ
cord-001835-0s7ok4uw	3883	3	been	be	VBN
cord-001835-0s7ok4uw	3883	4	suggested	suggest	VBN
cord-001835-0s7ok4uw	3883	5	that	that	IN
cord-001835-0s7ok4uw	3883	6	helices	helix	NNS
cord-001835-0s7ok4uw	3883	7	2	2	CD
cord-001835-0s7ok4uw	3883	8	and	and	CC
cord-001835-0s7ok4uw	3883	9	3	3	CD
cord-001835-0s7ok4uw	3883	10	form	form	NN
cord-001835-0s7ok4uw	3883	11	first	first	RB
cord-001835-0s7ok4uw	3883	12	at	at	IN
cord-001835-0s7ok4uw	3883	13	the	the	DT
cord-001835-0s7ok4uw	3883	14	initial	initial	JJ
cord-001835-0s7ok4uw	3883	15	stage	stage	NN
cord-001835-0s7ok4uw	3883	16	of	of	IN
cord-001835-0s7ok4uw	3883	17	folding	fold	VBG
cord-001835-0s7ok4uw	3883	18	in	in	IN
cord-001835-0s7ok4uw	3883	19	wild	wild	JJ
cord-001835-0s7ok4uw	3883	20	-	-	HYPH
cord-001835-0s7ok4uw	3883	21	type	type	NN
cord-001835-0s7ok4uw	3883	22	apo	apo	NNP
cord-001835-0s7ok4uw	3883	23	cyt	cyt	NNP
cord-001835-0s7ok4uw	3883	24	b562.4	b562.4	NNP
cord-001835-0s7ok4uw	3884	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	3884	2	,	,	,
cord-001835-0s7ok4uw	3884	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3884	4	propose	propose	VBP
cord-001835-0s7ok4uw	3884	5	that	that	IN
cord-001835-0s7ok4uw	3884	6	cyt	cyt	NN
cord-001835-0s7ok4uw	3884	7	cb562	cb562	NNP
cord-001835-0s7ok4uw	3884	8	forms	form	VBZ
cord-001835-0s7ok4uw	3884	9	a	a	DT
cord-001835-0s7ok4uw	3884	10	domain	domain	NN
cord-001835-0s7ok4uw	3884	11	-	-	HYPH
cord-001835-0s7ok4uw	3884	12	swapped	swap	VBN
cord-001835-0s7ok4uw	3884	13	dimer	dimer	NN
cord-001835-0s7ok4uw	3884	14	when	when	WRB
cord-001835-0s7ok4uw	3884	15	helices	helix	NNS
cord-001835-0s7ok4uw	3884	16	2	2	CD
cord-001835-0s7ok4uw	3884	17	and	and	CC
cord-001835-0s7ok4uw	3884	18	3	3	CD
cord-001835-0s7ok4uw	3884	19	interact	interact	VBP
cord-001835-0s7ok4uw	3884	20	intermolecularly	intermolecularly	RB
cord-001835-0s7ok4uw	3884	21	at	at	IN
cord-001835-0s7ok4uw	3884	22	the	the	DT
cord-001835-0s7ok4uw	3884	23	initial	initial	JJ
cord-001835-0s7ok4uw	3884	24	stage	stage	NN
cord-001835-0s7ok4uw	3884	25	of	of	IN
cord-001835-0s7ok4uw	3884	26	folding	folding	NN
cord-001835-0s7ok4uw	3884	27	,	,	,
cord-001835-0s7ok4uw	3884	28	whereas	whereas	IN
cord-001835-0s7ok4uw	3884	29	the	the	DT
cord-001835-0s7ok4uw	3884	30	intramolecular	intramolecular	JJ
cord-001835-0s7ok4uw	3884	31	interaction	interaction	NN
cord-001835-0s7ok4uw	3884	32	of	of	IN
cord-001835-0s7ok4uw	3884	33	helices	helix	NNS
cord-001835-0s7ok4uw	3884	34	2	2	CD
cord-001835-0s7ok4uw	3884	35	and	and	CC
cord-001835-0s7ok4uw	3884	36	3	3	CD
cord-001835-0s7ok4uw	3884	37	results	result	NNS
cord-001835-0s7ok4uw	3884	38	in	in	IN
cord-001835-0s7ok4uw	3884	39	formation	formation	NN
cord-001835-0s7ok4uw	3884	40	of	of	IN
cord-001835-0s7ok4uw	3884	41	a	a	DT
cord-001835-0s7ok4uw	3884	42	monomer	monomer	NN
cord-001835-0s7ok4uw	3884	43	.	.	.
cord-001835-0s7ok4uw	3884	44	 	 	_SP
cord-001835-0s7ok4uw	3885	1	A	a	DT
cord-001835-0s7ok4uw	3885	2	highly	highly	RB
cord-001835-0s7ok4uw	3885	3	buried	bury	VBN
cord-001835-0s7ok4uw	3885	4	and	and	CC
cord-001835-0s7ok4uw	3885	5	conserved	conserved	JJ
cord-001835-0s7ok4uw	3885	6	tryptophan	tryptophan	NN
cord-001835-0s7ok4uw	3885	7	residue	residue	NN
cord-001835-0s7ok4uw	3885	8	close	close	RB
cord-001835-0s7ok4uw	3885	9	to	to	IN
cord-001835-0s7ok4uw	3885	10	the	the	DT
cord-001835-0s7ok4uw	3885	11	dimer	dimer	NN
cord-001835-0s7ok4uw	3885	12	interface	interface	NN
cord-001835-0s7ok4uw	3885	13	in	in	IN
cord-001835-0s7ok4uw	3885	14	a	a	DT
cord-001835-0s7ok4uw	3885	15	cold	cold	RB
cord-001835-0s7ok4uw	3885	16	-	-	HYPH
cord-001835-0s7ok4uw	3885	17	adapted	adapt	VBN
cord-001835-0s7ok4uw	3885	18	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	3885	19	is	be	VBZ
cord-001835-0s7ok4uw	3885	20	phosphorescent	phosphorescent	JJ
cord-001835-0s7ok4uw	3885	21	and	and	CC
cord-001835-0s7ok4uw	3885	22	important	important	JJ
cord-001835-0s7ok4uw	3885	23	for	for	IN
cord-001835-0s7ok4uw	3885	24	activity	activity	NN
cord-001835-0s7ok4uw	3885	25	.	.	.
cord-001835-0s7ok4uw	3886	1	Jens	Jens	NNP
cord-001835-0s7ok4uw	3886	2	G.	G.	NNP
cord-001835-0s7ok4uw	3886	3	Hj€	Hj€	NNP
cord-001835-0s7ok4uw	3886	4	orleifsson	orleifsson	NN
cord-001835-0s7ok4uw	3886	5	and	and	CC
cord-001835-0s7ok4uw	3886	6	Bjarni	Bjarni	NNP
cord-001835-0s7ok4uw	3886	7	Asgeirsson	Asgeirsson	NNP
cord-001835-0s7ok4uw	3886	8	.	.	.
cord-001835-0s7ok4uw	3887	1	Department	Department	NNP
cord-001835-0s7ok4uw	3887	2	of	of	IN
cord-001835-0s7ok4uw	3887	3	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	3887	4	,	,	,
cord-001835-0s7ok4uw	3887	5	Science	Science	NNP
cord-001835-0s7ok4uw	3887	6	Institute	Institute	NNP
cord-001835-0s7ok4uw	3887	7	,	,	,
cord-001835-0s7ok4uw	3887	8	University	University	NNP
cord-001835-0s7ok4uw	3887	9	of	of	IN
cord-001835-0s7ok4uw	3887	10	Iceland	Iceland	NNP
cord-001835-0s7ok4uw	3887	11	,	,	,
cord-001835-0s7ok4uw	3887	12	Dunhagi	Dunhagi	NNP
cord-001835-0s7ok4uw	3887	13	3	3	CD
cord-001835-0s7ok4uw	3887	14	,	,	,
cord-001835-0s7ok4uw	3887	15	107	107	CD
cord-001835-0s7ok4uw	3887	16	Reykjavik	Reykjavik	NNP
cord-001835-0s7ok4uw	3887	17	,	,	,
cord-001835-0s7ok4uw	3887	18	Iceland	Iceland	NNP
cord-001835-0s7ok4uw	3887	19	.	.	.
cord-001835-0s7ok4uw	3888	1	Alkaline	alkaline	JJ
cord-001835-0s7ok4uw	3888	2	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	3888	3	(	(	-LRB-
cord-001835-0s7ok4uw	3888	4	AP	AP	NNP
cord-001835-0s7ok4uw	3888	5	)	)	-RRB-
cord-001835-0s7ok4uw	3888	6	from	from	IN
cord-001835-0s7ok4uw	3888	7	Vibrio	Vibrio	NNP
cord-001835-0s7ok4uw	3888	8	G15	G15	NNP
cord-001835-0s7ok4uw	3888	9	-	-	HYPH
cord-001835-0s7ok4uw	3888	10	21	21	CD
cord-001835-0s7ok4uw	3888	11	is	be	VBZ
cord-001835-0s7ok4uw	3888	12	a	a	DT
cord-001835-0s7ok4uw	3888	13	cold	cold	NN
cord-001835-0s7ok4uw	3888	14	-	-	HYPH
cord-001835-0s7ok4uw	3888	15	adapted	adapt	VBN
cord-001835-0s7ok4uw	3888	16	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	3888	17	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3888	18	with	with	IN
cord-001835-0s7ok4uw	3888	19	one	one	CD
cord-001835-0s7ok4uw	3888	20	of	of	IN
cord-001835-0s7ok4uw	3888	21	the	the	DT
cord-001835-0s7ok4uw	3888	22	highest	high	JJS
cord-001835-0s7ok4uw	3888	23	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	3888	24	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3888	25	reported	report	VBN
cord-001835-0s7ok4uw	3888	26	for	for	IN
cord-001835-0s7ok4uw	3888	27	known	know	VBN
cord-001835-0s7ok4uw	3888	28	APs	APs	NNP
cord-001835-0s7ok4uw	3888	29	.	.	.
cord-001835-0s7ok4uw	3889	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3889	2	contains	contain	VBZ
cord-001835-0s7ok4uw	3889	3	five	five	CD
cord-001835-0s7ok4uw	3889	4	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	3889	5	tryptophan	tryptophan	NN
cord-001835-0s7ok4uw	3889	6	(	(	-LRB-
cord-001835-0s7ok4uw	3889	7	Trp	trp	NN
cord-001835-0s7ok4uw	3889	8	)	)	-RRB-
cord-001835-0s7ok4uw	3889	9	residues	residue	NNS
cord-001835-0s7ok4uw	3889	10	and	and	CC
cord-001835-0s7ok4uw	3889	11	one	one	CD
cord-001835-0s7ok4uw	3889	12	additional	additional	JJ
cord-001835-0s7ok4uw	3889	13	Trp	trp	NN
cord-001835-0s7ok4uw	3889	14	located	locate	VBN
cord-001835-0s7ok4uw	3889	15	on	on	IN
cord-001835-0s7ok4uw	3889	16	the	the	DT
cord-001835-0s7ok4uw	3889	17	C	C	NNP
cord-001835-0s7ok4uw	3889	18	-	-	HYPH
cord-001835-0s7ok4uw	3889	19	terminal	terminal	NN
cord-001835-0s7ok4uw	3889	20	StrepTag	StrepTag	NNP
cord-001835-0s7ok4uw	3889	21	used	use	VBD
cord-001835-0s7ok4uw	3889	22	for	for	IN
cord-001835-0s7ok4uw	3889	23	expression	expression	NN
cord-001835-0s7ok4uw	3889	24	and	and	CC
cord-001835-0s7ok4uw	3889	25	purification	purification	NN
cord-001835-0s7ok4uw	3889	26	.	.	.
cord-001835-0s7ok4uw	3890	1	In	in	IN
cord-001835-0s7ok4uw	3890	2	this	this	DT
cord-001835-0s7ok4uw	3890	3	study	study	NN
cord-001835-0s7ok4uw	3890	4	,	,	,
cord-001835-0s7ok4uw	3890	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3890	6	made	make	VBD
cord-001835-0s7ok4uw	3890	7	several	several	JJ
cord-001835-0s7ok4uw	3890	8	single	single	JJ
cord-001835-0s7ok4uw	3890	9	Trp	trp	NN
cord-001835-0s7ok4uw	3890	10	-	-	HYPH
cord-001835-0s7ok4uw	3890	11	substitutions	substitution	NNS
cord-001835-0s7ok4uw	3890	12	to	to	TO
cord-001835-0s7ok4uw	3890	13	determine	determine	VB
cord-001835-0s7ok4uw	3890	14	the	the	DT
cord-001835-0s7ok4uw	3890	15	role	role	NN
cord-001835-0s7ok4uw	3890	16	of	of	IN
cord-001835-0s7ok4uw	3890	17	each	each	DT
cord-001835-0s7ok4uw	3890	18	of	of	IN
cord-001835-0s7ok4uw	3890	19	the	the	DT
cord-001835-0s7ok4uw	3890	20	Trp	trp	NN
cord-001835-0s7ok4uw	3890	21	in	in	IN
cord-001835-0s7ok4uw	3890	22	the	the	DT
cord-001835-0s7ok4uw	3890	23	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3890	24	emission	emission	NN
cord-001835-0s7ok4uw	3890	25	spectrum	spectrum	NN
cord-001835-0s7ok4uw	3890	26	.	.	.
cord-001835-0s7ok4uw	3891	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3891	2	also	also	RB
cord-001835-0s7ok4uw	3891	3	determined	determine	VBD
cord-001835-0s7ok4uw	3891	4	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3891	5	solvent	solvent	NN
cord-001835-0s7ok4uw	3891	6	exposure	exposure	NN
cord-001835-0s7ok4uw	3891	7	by	by	IN
cord-001835-0s7ok4uw	3891	8	acrylamide	acrylamide	NN
cord-001835-0s7ok4uw	3891	9	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3891	10	quenching	quenching	NN
cord-001835-0s7ok4uw	3891	11	.	.	.
cord-001835-0s7ok4uw	3892	1	The	the	DT
cord-001835-0s7ok4uw	3892	2	results	result	NNS
cord-001835-0s7ok4uw	3892	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	3892	4	that	that	IN
cord-001835-0s7ok4uw	3892	5	Trp301	trp301	CD
cord-001835-0s7ok4uw	3892	6	,	,	,
cord-001835-0s7ok4uw	3892	7	Trp460	trp460	CD
cord-001835-0s7ok4uw	3892	8	and	and	CC
cord-001835-0s7ok4uw	3892	9	Trp475	trp475	NN
cord-001835-0s7ok4uw	3892	10	are	be	VBP
cord-001835-0s7ok4uw	3892	11	mostly	mostly	RB
cord-001835-0s7ok4uw	3892	12	responsible	responsible	JJ
cord-001835-0s7ok4uw	3892	13	for	for	IN
cord-001835-0s7ok4uw	3892	14	the	the	DT
cord-001835-0s7ok4uw	3892	15	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	3892	16	emission	emission	NN
cord-001835-0s7ok4uw	3892	17	.	.	.
cord-001835-0s7ok4uw	3893	1	Quenching	quenching	NN
cord-001835-0s7ok4uw	3893	2	experiments	experiment	NNS
cord-001835-0s7ok4uw	3893	3	with	with	IN
cord-001835-0s7ok4uw	3893	4	acrylamide	acrylamide	NN
cord-001835-0s7ok4uw	3893	5	indicated	indicate	VBD
cord-001835-0s7ok4uw	3893	6	that	that	IN
cord-001835-0s7ok4uw	3893	7	all	all	PDT
cord-001835-0s7ok4uw	3893	8	the	the	DT
cord-001835-0s7ok4uw	3893	9	Trp	trp	NN
cord-001835-0s7ok4uw	3893	10	residues	residue	NNS
cord-001835-0s7ok4uw	3893	11	were	be	VBD
cord-001835-0s7ok4uw	3893	12	about	about	RB
cord-001835-0s7ok4uw	3893	13	equally	equally	RB
cord-001835-0s7ok4uw	3893	14	accessible	accessible	JJ
cord-001835-0s7ok4uw	3893	15	for	for	IN
cord-001835-0s7ok4uw	3893	16	quenching	quenching	NN
cord-001835-0s7ok4uw	3893	17	,	,	,
cord-001835-0s7ok4uw	3893	18	except	except	IN
cord-001835-0s7ok4uw	3893	19	Trp460	trp460	DT
cord-001835-0s7ok4uw	3893	20	which	which	WDT
cord-001835-0s7ok4uw	3893	21	was	be	VBD
cord-001835-0s7ok4uw	3893	22	shown	show	VBN
cord-001835-0s7ok4uw	3893	23	to	to	TO
cord-001835-0s7ok4uw	3893	24	be	be	VB
cord-001835-0s7ok4uw	3893	25	highly	highly	RB
cord-001835-0s7ok4uw	3893	26	buried	bury	VBN
cord-001835-0s7ok4uw	3893	27	in	in	IN
cord-001835-0s7ok4uw	3893	28	the	the	DT
cord-001835-0s7ok4uw	3893	29	core	core	NN
cord-001835-0s7ok4uw	3893	30	of	of	IN
cord-001835-0s7ok4uw	3893	31	the	the	DT
cord-001835-0s7ok4uw	3893	32	protein	protein	NN
cord-001835-0s7ok4uw	3893	33	.	.	.
cord-001835-0s7ok4uw	3894	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	3894	2	,	,	,
cord-001835-0s7ok4uw	3894	3	the	the	DT
cord-001835-0s7ok4uw	3894	4	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3894	5	was	be	VBD
cord-001835-0s7ok4uw	3894	6	found	find	VBN
cord-001835-0s7ok4uw	3894	7	to	to	TO
cord-001835-0s7ok4uw	3894	8	be	be	VB
cord-001835-0s7ok4uw	3894	9	highly	highly	RB
cord-001835-0s7ok4uw	3894	10	phosphorescent	phosphorescent	JJ
cord-001835-0s7ok4uw	3894	11	at	at	IN
cord-001835-0s7ok4uw	3894	12	108C	108c	CD
cord-001835-0s7ok4uw	3894	13	,	,	,
cord-001835-0s7ok4uw	3894	14	having	have	VBG
cord-001835-0s7ok4uw	3894	15	two	two	CD
cord-001835-0s7ok4uw	3894	16	phosphorescence	phosphorescence	NN
cord-001835-0s7ok4uw	3894	17	lifetimes	lifetime	NNS
cord-001835-0s7ok4uw	3894	18	.	.	.
cord-001835-0s7ok4uw	3895	1	The	the	DT
cord-001835-0s7ok4uw	3895	2	longer	long	JJR
cord-001835-0s7ok4uw	3895	3	lifetime	lifetime	NN
cord-001835-0s7ok4uw	3895	4	is	be	VBZ
cord-001835-0s7ok4uw	3895	5	due	due	JJ
cord-001835-0s7ok4uw	3895	6	to	to	IN
cord-001835-0s7ok4uw	3895	7	Trp460	trp460	CD
cord-001835-0s7ok4uw	3895	8	.	.	.
cord-001835-0s7ok4uw	3896	1	Trp460	Trp460	NNP
cord-001835-0s7ok4uw	3896	2	is	be	VBZ
cord-001835-0s7ok4uw	3896	3	located	locate	VBN
cord-001835-0s7ok4uw	3896	4	close	close	RB
cord-001835-0s7ok4uw	3896	5	to	to	IN
cord-001835-0s7ok4uw	3896	6	the	the	DT
cord-001835-0s7ok4uw	3896	7	dimer	dimer	NN
cord-001835-0s7ok4uw	3896	8	interface	interface	NN
cord-001835-0s7ok4uw	3896	9	and	and	CC
cord-001835-0s7ok4uw	3896	10	points	point	NNS
cord-001835-0s7ok4uw	3896	11	towards	towards	IN
cord-001835-0s7ok4uw	3896	12	a	a	DT
cord-001835-0s7ok4uw	3896	13	helix	helix	NN
cord-001835-0s7ok4uw	3896	14	in	in	IN
cord-001835-0s7ok4uw	3896	15	the	the	DT
cord-001835-0s7ok4uw	3896	16	active	active	JJ
cord-001835-0s7ok4uw	3896	17	site	site	NN
cord-001835-0s7ok4uw	3896	18	where	where	WRB
cord-001835-0s7ok4uw	3896	19	His277	His277	NNP
cord-001835-0s7ok4uw	3896	20	binds	bind	VBZ
cord-001835-0s7ok4uw	3896	21	an	an	DT
cord-001835-0s7ok4uw	3896	22	active	active	JJ
cord-001835-0s7ok4uw	3896	23	-	-	HYPH
cord-001835-0s7ok4uw	3896	24	site	site	NN
cord-001835-0s7ok4uw	3896	25	zinc	zinc	NN
cord-001835-0s7ok4uw	3896	26	ion	ion	NN
cord-001835-0s7ok4uw	3896	27	.	.	.
cord-001835-0s7ok4uw	3897	1	In	in	IN
cord-001835-0s7ok4uw	3897	2	other	other	JJ
cord-001835-0s7ok4uw	3897	3	APs	ap	NNS
cord-001835-0s7ok4uw	3897	4	,	,	,
cord-001835-0s7ok4uw	3897	5	an	an	DT
cord-001835-0s7ok4uw	3897	6	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	3897	7	amino	amino	NN
cord-001835-0s7ok4uw	3897	8	acid	acid	NN
cord-001835-0s7ok4uw	3897	9	is	be	VBZ
cord-001835-0s7ok4uw	3897	10	conserved	conserve	VBN
cord-001835-0s7ok4uw	3897	11	in	in	IN
cord-001835-0s7ok4uw	3897	12	the	the	DT
cord-001835-0s7ok4uw	3897	13	location	location	NN
cord-001835-0s7ok4uw	3897	14	occupied	occupy	VBN
cord-001835-0s7ok4uw	3897	15	by	by	IN
cord-001835-0s7ok4uw	3897	16	the	the	DT
cord-001835-0s7ok4uw	3897	17	Trp460	trp460	CD
cord-001835-0s7ok4uw	3897	18	residue	residue	NN
cord-001835-0s7ok4uw	3897	19	.	.	.
cord-001835-0s7ok4uw	3898	1	In	in	IN
cord-001835-0s7ok4uw	3898	2	most	most	JJS
cord-001835-0s7ok4uw	3898	3	cases	case	NNS
cord-001835-0s7ok4uw	3898	4	for	for	IN
cord-001835-0s7ok4uw	3898	5	cold	cold	NN
cord-001835-0s7ok4uw	3898	6	-	-	HYPH
cord-001835-0s7ok4uw	3898	7	adapted	adapt	VBN
cord-001835-0s7ok4uw	3898	8	APs	APs	NNP
cord-001835-0s7ok4uw	3898	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	3898	10	is	be	VBZ
cord-001835-0s7ok4uw	3898	11	indeed	indeed	RB
cord-001835-0s7ok4uw	3898	12	a	a	DT
cord-001835-0s7ok4uw	3898	13	Trp	trp	NN
cord-001835-0s7ok4uw	3898	14	.	.	.
cord-001835-0s7ok4uw	3899	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	3899	2	,	,	,
cord-001835-0s7ok4uw	3899	3	the	the	DT
cord-001835-0s7ok4uw	3899	4	mutation	mutation	NN
cord-001835-0s7ok4uw	3899	5	of	of	IN
cord-001835-0s7ok4uw	3899	6	the	the	DT
cord-001835-0s7ok4uw	3899	7	Trp460	trp460	CD
cord-001835-0s7ok4uw	3899	8	to	to	IN
cord-001835-0s7ok4uw	3899	9	a	a	DT
cord-001835-0s7ok4uw	3899	10	phenylalanine	phenylalanine	NN
cord-001835-0s7ok4uw	3899	11	affected	affect	VBN
cord-001835-0s7ok4uw	3899	12	both	both	CC
cord-001835-0s7ok4uw	3899	13	stability	stability	NN
cord-001835-0s7ok4uw	3899	14	and	and	CC
cord-001835-0s7ok4uw	3899	15	activity	activity	NN
cord-001835-0s7ok4uw	3899	16	of	of	IN
cord-001835-0s7ok4uw	3899	17	the	the	DT
cord-001835-0s7ok4uw	3899	18	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3899	19	.	.	.
cord-001835-0s7ok4uw	3900	1	kcat	kcat	NNP
cord-001835-0s7ok4uw	3900	2	/	/	SYM
cord-001835-0s7ok4uw	3900	3	KM	KM	NNP
cord-001835-0s7ok4uw	3900	4	was	be	VBD
cord-001835-0s7ok4uw	3900	5	10-fold	10-fold	JJ
cord-001835-0s7ok4uw	3900	6	lower	low	JJR
cord-001835-0s7ok4uw	3900	7	than	than	IN
cord-001835-0s7ok4uw	3900	8	for	for	IN
cord-001835-0s7ok4uw	3900	9	wild	wild	JJ
cord-001835-0s7ok4uw	3900	10	-	-	HYPH
cord-001835-0s7ok4uw	3900	11	type	type	NN
cord-001835-0s7ok4uw	3900	12	.	.	.
cord-001835-0s7ok4uw	3901	1	Overall	overall	RB
cord-001835-0s7ok4uw	3901	2	,	,	,
cord-001835-0s7ok4uw	3901	3	this	this	DT
cord-001835-0s7ok4uw	3901	4	study	study	NN
cord-001835-0s7ok4uw	3901	5	reveals	reveal	VBZ
cord-001835-0s7ok4uw	3901	6	that	that	IN
cord-001835-0s7ok4uw	3901	7	Trp460	trp460	DT
cord-001835-0s7ok4uw	3901	8	can	can	MD
cord-001835-0s7ok4uw	3901	9	be	be	VB
cord-001835-0s7ok4uw	3901	10	used	use	VBN
cord-001835-0s7ok4uw	3901	11	as	as	IN
cord-001835-0s7ok4uw	3901	12	a	a	DT
cord-001835-0s7ok4uw	3901	13	phosphorescent	phosphorescent	JJ
cord-001835-0s7ok4uw	3901	14	probe	probe	NN
cord-001835-0s7ok4uw	3901	15	of	of	IN
cord-001835-0s7ok4uw	3901	16	local	local	JJ
cord-001835-0s7ok4uw	3901	17	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	3901	18	and	and	CC
cord-001835-0s7ok4uw	3901	19	could	could	MD
cord-001835-0s7ok4uw	3901	20	possibly	possibly	RB
cord-001835-0s7ok4uw	3901	21	also	also	RB
cord-001835-0s7ok4uw	3901	22	serve	serve	VB
cord-001835-0s7ok4uw	3901	23	to	to	TO
cord-001835-0s7ok4uw	3901	24	study	study	VB
cord-001835-0s7ok4uw	3901	25	the	the	DT
cord-001835-0s7ok4uw	3901	26	dimer	dimer	NN
cord-001835-0s7ok4uw	3901	27	-	-	HYPH
cord-001835-0s7ok4uw	3901	28	monomer	monomer	NN
cord-001835-0s7ok4uw	3901	29	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	3901	30	due	due	IN
cord-001835-0s7ok4uw	3901	31	to	to	IN
cord-001835-0s7ok4uw	3901	32	proximity	proximity	NN
cord-001835-0s7ok4uw	3901	33	to	to	IN
cord-001835-0s7ok4uw	3901	34	the	the	DT
cord-001835-0s7ok4uw	3901	35	dimer	dimer	NN
cord-001835-0s7ok4uw	3901	36	interface	interface	NN
cord-001835-0s7ok4uw	3901	37	,	,	,
cord-001835-0s7ok4uw	3901	38	an	an	DT
cord-001835-0s7ok4uw	3901	39	area	area	NN
cord-001835-0s7ok4uw	3901	40	clearly	clearly	RB
cord-001835-0s7ok4uw	3901	41	crucial	crucial	JJ
cord-001835-0s7ok4uw	3901	42	for	for	IN
cord-001835-0s7ok4uw	3901	43	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3901	44	activity	activity	NN
cord-001835-0s7ok4uw	3901	45	and	and	CC
cord-001835-0s7ok4uw	3901	46	stability	stability	NN
cord-001835-0s7ok4uw	3901	47	.	.	.
cord-001835-0s7ok4uw	3902	1	Modulating	modulate	VBG
cord-001835-0s7ok4uw	3902	2	protein	protein	NN
cord-001835-0s7ok4uw	3902	3	-	-	HYPH
cord-001835-0s7ok4uw	3902	4	protein	protein	NN
cord-001835-0s7ok4uw	3902	5	interaction	interaction	NN
cord-001835-0s7ok4uw	3902	6	with	with	IN
cord-001835-0s7ok4uw	3902	7	a	a	DT
cord-001835-0s7ok4uw	3902	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	3902	9	tether	tether	NN
cord-001835-0s7ok4uw	3902	10	Helen	Helen	NNP
cord-001835-0s7ok4uw	3902	11	Farrants	Farrants	NNP
cord-001835-0s7ok4uw	3902	12	1	1	CD
cord-001835-0s7ok4uw	3902	13	,	,	,
cord-001835-0s7ok4uw	3902	14	Oliver	Oliver	NNP
cord-001835-0s7ok4uw	3902	15	Hantschel	Hantschel	NNP
cord-001835-0s7ok4uw	3902	16	1	1	CD
cord-001835-0s7ok4uw	3902	17	,	,	,
cord-001835-0s7ok4uw	3902	18	Kai	Kai	NNP
cord-001835-0s7ok4uw	3902	19	Johnsson	Johnsson	NNP
cord-001835-0s7ok4uw	3902	20	1	1	CD
cord-001835-0s7ok4uw	3902	21	1	1	CD
cord-001835-0s7ok4uw	3902	22	Ecole	Ecole	NNP
cord-001835-0s7ok4uw	3902	23	Polytechnique	Polytechnique	NNP
cord-001835-0s7ok4uw	3902	24	F	F	NNP
cord-001835-0s7ok4uw	3902	25	ed	ed	NN
cord-001835-0s7ok4uw	3902	26	erale	erale	NN
cord-001835-0s7ok4uw	3902	27	de	de	FW
cord-001835-0s7ok4uw	3902	28	Lausanne	Lausanne	NNP
cord-001835-0s7ok4uw	3902	29	(	(	-LRB-
cord-001835-0s7ok4uw	3902	30	EPFL	EPFL	NNP
cord-001835-0s7ok4uw	3902	31	)	)	-RRB-
cord-001835-0s7ok4uw	3902	32	High	high	JJ
cord-001835-0s7ok4uw	3902	33	-	-	HYPH
cord-001835-0s7ok4uw	3902	34	affinity	affinity	NN
cord-001835-0s7ok4uw	3902	35	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3902	36	for	for	IN
cord-001835-0s7ok4uw	3902	37	protein	protein	NN
cord-001835-0s7ok4uw	3902	38	-	-	HYPH
cord-001835-0s7ok4uw	3902	39	protein	protein	NN
cord-001835-0s7ok4uw	3902	40	interactions	interaction	NNS
cord-001835-0s7ok4uw	3902	41	,	,	,
cord-001835-0s7ok4uw	3902	42	such	such	JJ
cord-001835-0s7ok4uw	3902	43	as	as	IN
cord-001835-0s7ok4uw	3902	44	monobodies	monobodie	NNS
cord-001835-0s7ok4uw	3902	45	and	and	CC
cord-001835-0s7ok4uw	3902	46	DARPins	darpin	NNS
cord-001835-0s7ok4uw	3902	47	can	can	MD
cord-001835-0s7ok4uw	3902	48	be	be	VB
cord-001835-0s7ok4uw	3902	49	engineered	engineer	VBN
cord-001835-0s7ok4uw	3902	50	in	in	IN
cord-001835-0s7ok4uw	3902	51	vitro	vitro	FW
cord-001835-0s7ok4uw	3902	52	to	to	TO
cord-001835-0s7ok4uw	3902	53	bind	bind	VB
cord-001835-0s7ok4uw	3902	54	to	to	IN
cord-001835-0s7ok4uw	3902	55	protein	protein	NN
cord-001835-0s7ok4uw	3902	56	targets	target	NNS
cord-001835-0s7ok4uw	3902	57	.	.	.
cord-001835-0s7ok4uw	3903	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3903	2	speculate	speculate	VBP
cord-001835-0s7ok4uw	3903	3	that	that	IN
cord-001835-0s7ok4uw	3903	4	the	the	DT
cord-001835-0s7ok4uw	3903	5	affinity	affinity	NN
cord-001835-0s7ok4uw	3903	6	for	for	IN
cord-001835-0s7ok4uw	3903	7	the	the	DT
cord-001835-0s7ok4uw	3903	8	target	target	NN
cord-001835-0s7ok4uw	3903	9	protein	protein	NN
cord-001835-0s7ok4uw	3903	10	can	can	MD
cord-001835-0s7ok4uw	3903	11	be	be	VB
cord-001835-0s7ok4uw	3903	12	modulated	modulate	VBN
cord-001835-0s7ok4uw	3903	13	by	by	IN
cord-001835-0s7ok4uw	3903	14	incorporating	incorporate	VBG
cord-001835-0s7ok4uw	3903	15	these	these	DT
cord-001835-0s7ok4uw	3903	16	evolved	evolve	VBN
cord-001835-0s7ok4uw	3903	17	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3903	18	and	and	CC
cord-001835-0s7ok4uw	3903	19	a	a	DT
cord-001835-0s7ok4uw	3903	20	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3903	21	intramolecular	intramolecular	JJ
cord-001835-0s7ok4uw	3903	22	tether	tether	NN
cord-001835-0s7ok4uw	3903	23	into	into	IN
cord-001835-0s7ok4uw	3903	24	protein	protein	NN
cord-001835-0s7ok4uw	3903	25	switches	switch	NNS
cord-001835-0s7ok4uw	3903	26	,	,	,
cord-001835-0s7ok4uw	3903	27	in	in	IN
cord-001835-0s7ok4uw	3903	28	a	a	DT
cord-001835-0s7ok4uw	3903	29	protein	protein	NN
cord-001835-0s7ok4uw	3903	30	construct	construct	NN
cord-001835-0s7ok4uw	3903	31	of	of	IN
cord-001835-0s7ok4uw	3903	32	composed	compose	VBN
cord-001835-0s7ok4uw	3903	33	of	of	IN
cord-001835-0s7ok4uw	3903	34	SNAP	snap	VB
cord-001835-0s7ok4uw	3903	35	-	-	HYPH
cord-001835-0s7ok4uw	3903	36	tag	tag	NN
cord-001835-0s7ok4uw	3903	37	,	,	,
cord-001835-0s7ok4uw	3903	38	a	a	DT
cord-001835-0s7ok4uw	3903	39	monobody	monobody	NN
cord-001835-0s7ok4uw	3903	40	and	and	CC
cord-001835-0s7ok4uw	3903	41	a	a	DT
cord-001835-0s7ok4uw	3903	42	circular	circular	JJ
cord-001835-0s7ok4uw	3903	43	permutated	permutate	VBN
cord-001835-0s7ok4uw	3903	44	dihydrofolate	dihydrofolate	NNP
cord-001835-0s7ok4uw	3903	45	reductase	reductase	NN
cord-001835-0s7ok4uw	3903	46	.	.	.
cord-001835-0s7ok4uw	3904	1	The	the	DT
cord-001835-0s7ok4uw	3904	2	tether	tether	NN
cord-001835-0s7ok4uw	3904	3	,	,	,
cord-001835-0s7ok4uw	3904	4	attached	attach	VBN
cord-001835-0s7ok4uw	3904	5	to	to	IN
cord-001835-0s7ok4uw	3904	6	the	the	DT
cord-001835-0s7ok4uw	3904	7	construct	construct	NN
cord-001835-0s7ok4uw	3904	8	via	via	IN
cord-001835-0s7ok4uw	3904	9	SNAP	snap	VB
cord-001835-0s7ok4uw	3904	10	-	-	HYPH
cord-001835-0s7ok4uw	3904	11	tag	tag	NN
cord-001835-0s7ok4uw	3904	12	,	,	,
cord-001835-0s7ok4uw	3904	13	was	be	VBD
cord-001835-0s7ok4uw	3904	14	composed	compose	VBN
cord-001835-0s7ok4uw	3904	15	of	of	IN
cord-001835-0s7ok4uw	3904	16	a	a	DT
cord-001835-0s7ok4uw	3904	17	linker	linker	NN
cord-001835-0s7ok4uw	3904	18	and	and	CC
cord-001835-0s7ok4uw	3904	19	trimethoprim	trimethoprim	NN
cord-001835-0s7ok4uw	3904	20	,	,	,
cord-001835-0s7ok4uw	3904	21	which	which	WDT
cord-001835-0s7ok4uw	3904	22	interacts	interact	VBZ
cord-001835-0s7ok4uw	3904	23	reversibly	reversibly	RB
cord-001835-0s7ok4uw	3904	24	with	with	IN
cord-001835-0s7ok4uw	3904	25	the	the	DT
cord-001835-0s7ok4uw	3904	26	circular	circular	JJ
cord-001835-0s7ok4uw	3904	27	permutated	permutate	VBN
cord-001835-0s7ok4uw	3904	28	dihydrofolate	dihydrofolate	NNP
cord-001835-0s7ok4uw	3904	29	reductase	reductase	NN
cord-001835-0s7ok4uw	3904	30	.	.	.
cord-001835-0s7ok4uw	3905	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3905	2	have	have	VBP
cord-001835-0s7ok4uw	3905	3	investigated	investigate	VBN
cord-001835-0s7ok4uw	3905	4	the	the	DT
cord-001835-0s7ok4uw	3905	5	affinity	affinity	NN
cord-001835-0s7ok4uw	3905	6	between	between	IN
cord-001835-0s7ok4uw	3905	7	the	the	DT
cord-001835-0s7ok4uw	3905	8	N	N	NNP
cord-001835-0s7ok4uw	3905	9	-	-	HYPH
cord-001835-0s7ok4uw	3905	10	SH2	SH2	NNP
cord-001835-0s7ok4uw	3905	11	domain	domain	NN
cord-001835-0s7ok4uw	3905	12	of	of	IN
cord-001835-0s7ok4uw	3905	13	the	the	DT
cord-001835-0s7ok4uw	3905	14	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	3905	15	Shp2	shp2	NN
cord-001835-0s7ok4uw	3905	16	and	and	CC
cord-001835-0s7ok4uw	3905	17	an	an	DT
cord-001835-0s7ok4uw	3905	18	evolved	evolved	JJ
cord-001835-0s7ok4uw	3905	19	monobody	monobody	NN
cord-001835-0s7ok4uw	3905	20	in	in	IN
cord-001835-0s7ok4uw	3905	21	such	such	PDT
cord-001835-0s7ok4uw	3905	22	a	a	DT
cord-001835-0s7ok4uw	3905	23	protein	protein	NN
cord-001835-0s7ok4uw	3905	24	construct	construct	NN
cord-001835-0s7ok4uw	3905	25	using	use	VBG
cord-001835-0s7ok4uw	3905	26	a	a	DT
cord-001835-0s7ok4uw	3905	27	FRET	fret	NN
cord-001835-0s7ok4uw	3905	28	assay	assay	NN
cord-001835-0s7ok4uw	3905	29	.	.	.
cord-001835-0s7ok4uw	3906	1	When	when	WRB
cord-001835-0s7ok4uw	3906	2	the	the	DT
cord-001835-0s7ok4uw	3906	3	intramolecular	intramolecular	JJ
cord-001835-0s7ok4uw	3906	4	tether	tether	NN
cord-001835-0s7ok4uw	3906	5	was	be	VBD
cord-001835-0s7ok4uw	3906	6	bound	bind	VBN
cord-001835-0s7ok4uw	3906	7	the	the	DT
cord-001835-0s7ok4uw	3906	8	circular	circular	JJ
cord-001835-0s7ok4uw	3906	9	permutated	permutate	VBN
cord-001835-0s7ok4uw	3906	10	dihydrofolate	dihydrofolate	NNP
cord-001835-0s7ok4uw	3906	11	reductase	reductase	NNP
cord-001835-0s7ok4uw	3906	12	(	(	-LRB-
cord-001835-0s7ok4uw	3906	13	"	"	``
cord-001835-0s7ok4uw	3906	14	closed	closed	JJ
cord-001835-0s7ok4uw	3906	15	"	"	''
cord-001835-0s7ok4uw	3906	16	conformation	conformation	NN
cord-001835-0s7ok4uw	3906	17	)	)	-RRB-
cord-001835-0s7ok4uw	3906	18	,	,	,
cord-001835-0s7ok4uw	3906	19	there	there	EX
cord-001835-0s7ok4uw	3906	20	was	be	VBD
cord-001835-0s7ok4uw	3906	21	an	an	DT
cord-001835-0s7ok4uw	3906	22	increase	increase	NN
cord-001835-0s7ok4uw	3906	23	in	in	IN
cord-001835-0s7ok4uw	3906	24	the	the	DT
cord-001835-0s7ok4uw	3906	25	affinity	affinity	NN
cord-001835-0s7ok4uw	3906	26	of	of	IN
cord-001835-0s7ok4uw	3906	27	the	the	DT
cord-001835-0s7ok4uw	3906	28	construct	construct	NN
cord-001835-0s7ok4uw	3906	29	to	to	IN
cord-001835-0s7ok4uw	3906	30	the	the	DT
cord-001835-0s7ok4uw	3906	31	target	target	NN
cord-001835-0s7ok4uw	3906	32	N	N	NNP
cord-001835-0s7ok4uw	3906	33	-	-	HYPH
cord-001835-0s7ok4uw	3906	34	SH2	SH2	NNP
cord-001835-0s7ok4uw	3906	35	.	.	.
cord-001835-0s7ok4uw	3907	1	In	in	IN
cord-001835-0s7ok4uw	3907	2	the	the	DT
cord-001835-0s7ok4uw	3907	3	presence	presence	NN
cord-001835-0s7ok4uw	3907	4	of	of	IN
cord-001835-0s7ok4uw	3907	5	a	a	DT
cord-001835-0s7ok4uw	3907	6	small	small	JJ
cord-001835-0s7ok4uw	3907	7	molecule	molecule	NN
cord-001835-0s7ok4uw	3907	8	competitor	competitor	NN
cord-001835-0s7ok4uw	3907	9	(	(	-LRB-
cord-001835-0s7ok4uw	3907	10	"	"	``
cord-001835-0s7ok4uw	3907	11	open	open	JJ
cord-001835-0s7ok4uw	3907	12	"	"	''
cord-001835-0s7ok4uw	3907	13	conformation	conformation	NN
cord-001835-0s7ok4uw	3907	14	)	)	-RRB-
cord-001835-0s7ok4uw	3908	1	the	the	DT
cord-001835-0s7ok4uw	3908	2	affinity	affinity	NN
cord-001835-0s7ok4uw	3908	3	of	of	IN
cord-001835-0s7ok4uw	3908	4	the	the	DT
cord-001835-0s7ok4uw	3908	5	monobody	monobody	NN
cord-001835-0s7ok4uw	3908	6	construct	construct	VB
cord-001835-0s7ok4uw	3908	7	to	to	IN
cord-001835-0s7ok4uw	3908	8	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3908	9	target	target	NN
cord-001835-0s7ok4uw	3908	10	was	be	VBD
cord-001835-0s7ok4uw	3908	11	reverted	revert	VBN
cord-001835-0s7ok4uw	3908	12	to	to	IN
cord-001835-0s7ok4uw	3908	13	the	the	DT
cord-001835-0s7ok4uw	3908	14	value	value	NN
cord-001835-0s7ok4uw	3908	15	reported	report	VBN
cord-001835-0s7ok4uw	3908	16	in	in	IN
cord-001835-0s7ok4uw	3908	17	the	the	DT
cord-001835-0s7ok4uw	3908	18	literature	literature	NN
cord-001835-0s7ok4uw	3908	19	.	.	.
cord-001835-0s7ok4uw	3909	1	The	the	DT
cord-001835-0s7ok4uw	3909	2	intramolecular	intramolecular	JJ
cord-001835-0s7ok4uw	3909	3	tether	tether	NN
cord-001835-0s7ok4uw	3909	4	in	in	IN
cord-001835-0s7ok4uw	3909	5	these	these	DT
cord-001835-0s7ok4uw	3909	6	protein	protein	NN
cord-001835-0s7ok4uw	3909	7	constructs	construct	NNS
cord-001835-0s7ok4uw	3909	8	combined	combine	VBN
cord-001835-0s7ok4uw	3909	9	with	with	IN
cord-001835-0s7ok4uw	3909	10	engineered	engineer	VBN
cord-001835-0s7ok4uw	3909	11	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	3909	12	for	for	IN
cord-001835-0s7ok4uw	3909	13	protein	protein	NN
cord-001835-0s7ok4uw	3909	14	-	-	HYPH
cord-001835-0s7ok4uw	3909	15	protein	protein	NN
cord-001835-0s7ok4uw	3909	16	interactions	interaction	NNS
cord-001835-0s7ok4uw	3909	17	may	may	MD
cord-001835-0s7ok4uw	3909	18	be	be	VB
cord-001835-0s7ok4uw	3909	19	a	a	DT
cord-001835-0s7ok4uw	3909	20	general	general	JJ
cord-001835-0s7ok4uw	3909	21	approach	approach	NN
cord-001835-0s7ok4uw	3909	22	towards	towards	IN
cord-001835-0s7ok4uw	3909	23	protein	protein	NN
cord-001835-0s7ok4uw	3909	24	switches	switch	NNS
cord-001835-0s7ok4uw	3909	25	.	.	.
cord-001835-0s7ok4uw	3909	26	 	 	_SP
cord-001835-0s7ok4uw	3910	1	Because	because	IN
cord-001835-0s7ok4uw	3910	2	most	most	JJS
cord-001835-0s7ok4uw	3910	3	proteins	protein	NNS
cord-001835-0s7ok4uw	3910	4	are	be	VBP
cord-001835-0s7ok4uw	3910	5	long	long	JJ
cord-001835-0s7ok4uw	3910	6	polymers	polymer	NNS
cord-001835-0s7ok4uw	3910	7	of	of	IN
cord-001835-0s7ok4uw	3910	8	amino	amino	NN
cord-001835-0s7ok4uw	3910	9	acids	acid	NNS
cord-001835-0s7ok4uw	3910	10	with	with	IN
cord-001835-0s7ok4uw	3910	11	twenty	twenty	CD
cord-001835-0s7ok4uw	3910	12	or	or	CC
cord-001835-0s7ok4uw	3910	13	more	more	RBR
cord-001835-0s7ok4uw	3910	14	chemically	chemically	RB
cord-001835-0s7ok4uw	3910	15	-	-	HYPH
cord-001835-0s7ok4uw	3910	16	distinct	distinct	JJ
cord-001835-0s7ok4uw	3910	17	sidechains	sidechain	NNS
cord-001835-0s7ok4uw	3910	18	,	,	,
cord-001835-0s7ok4uw	3910	19	there	there	EX
cord-001835-0s7ok4uw	3910	20	are	be	VBP
cord-001835-0s7ok4uw	3910	21	an	an	DT
cord-001835-0s7ok4uw	3910	22	enormous	enormous	JJ
cord-001835-0s7ok4uw	3910	23	number	number	NN
cord-001835-0s7ok4uw	3910	24	of	of	IN
cord-001835-0s7ok4uw	3910	25	potential	potential	JJ
cord-001835-0s7ok4uw	3910	26	protein	protein	NN
cord-001835-0s7ok4uw	3910	27	sequences	sequence	NNS
cord-001835-0s7ok4uw	3910	28	.	.	.
cord-001835-0s7ok4uw	3911	1	Here	here	RB
cord-001835-0s7ok4uw	3911	2	,	,	,
cord-001835-0s7ok4uw	3911	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3911	4	report	report	VBP
cord-001835-0s7ok4uw	3911	5	the	the	DT
cord-001835-0s7ok4uw	3911	6	construction	construction	NN
cord-001835-0s7ok4uw	3911	7	of	of	IN
cord-001835-0s7ok4uw	3911	8	biologically	biologically	RB
cord-001835-0s7ok4uw	3911	9	active	active	JJ
cord-001835-0s7ok4uw	3911	10	proteins	protein	NNS
cord-001835-0s7ok4uw	3911	11	with	with	IN
cord-001835-0s7ok4uw	3911	12	minimal	minimal	JJ
cord-001835-0s7ok4uw	3911	13	chemical	chemical	NN
cord-001835-0s7ok4uw	3911	14	diversity	diversity	NN
cord-001835-0s7ok4uw	3911	15	.	.	.
cord-001835-0s7ok4uw	3912	1	Transmembrane	Transmembrane	NNP
cord-001835-0s7ok4uw	3912	2	domains	domain	NNS
cord-001835-0s7ok4uw	3912	3	of	of	IN
cord-001835-0s7ok4uw	3912	4	proteins	protein	NNS
cord-001835-0s7ok4uw	3912	5	can	can	MD
cord-001835-0s7ok4uw	3912	6	specifically	specifically	RB
cord-001835-0s7ok4uw	3912	7	interact	interact	VB
cord-001835-0s7ok4uw	3912	8	with	with	IN
cord-001835-0s7ok4uw	3912	9	other	other	JJ
cord-001835-0s7ok4uw	3912	10	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	3912	11	domains	domain	NNS
cord-001835-0s7ok4uw	3912	12	to	to	TO
cord-001835-0s7ok4uw	3912	13	modulate	modulate	VB
cord-001835-0s7ok4uw	3912	14	the	the	DT
cord-001835-0s7ok4uw	3912	15	folding	folding	NN
cord-001835-0s7ok4uw	3912	16	,	,	,
cord-001835-0s7ok4uw	3912	17	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	3912	18	,	,	,
cord-001835-0s7ok4uw	3912	19	and	and	CC
cord-001835-0s7ok4uw	3912	20	function	function	NN
cord-001835-0s7ok4uw	3912	21	of	of	IN
cord-001835-0s7ok4uw	3912	22	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	3912	23	proteins	protein	NNS
cord-001835-0s7ok4uw	3912	24	.	.	.
cord-001835-0s7ok4uw	3913	1	For	for	IN
cord-001835-0s7ok4uw	3913	2	example	example	NN
cord-001835-0s7ok4uw	3913	3	,	,	,
cord-001835-0s7ok4uw	3913	4	the	the	DT
cord-001835-0s7ok4uw	3913	5	bovine	bovine	JJ
cord-001835-0s7ok4uw	3913	6	papillomavirus	papillomavirus	NN
cord-001835-0s7ok4uw	3913	7	E5	e5	NN
cord-001835-0s7ok4uw	3913	8	protein	protein	NN
cord-001835-0s7ok4uw	3913	9	is	be	VBZ
cord-001835-0s7ok4uw	3913	10	a	a	DT
cord-001835-0s7ok4uw	3913	11	44-amino	44-amino	CD
cord-001835-0s7ok4uw	3913	12	acid	acid	NN
cord-001835-0s7ok4uw	3913	13	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	3913	14	protein	protein	NN
cord-001835-0s7ok4uw	3913	15	that	that	WDT
cord-001835-0s7ok4uw	3913	16	transforms	transform	VBZ
cord-001835-0s7ok4uw	3913	17	fibroblasts	fibroblast	NNS
cord-001835-0s7ok4uw	3913	18	to	to	IN
cord-001835-0s7ok4uw	3913	19	tumorigenicity	tumorigenicity	NN
cord-001835-0s7ok4uw	3913	20	by	by	IN
cord-001835-0s7ok4uw	3913	21	binding	bind	VBG
cord-001835-0s7ok4uw	3913	22	directly	directly	RB
cord-001835-0s7ok4uw	3913	23	to	to	IN
cord-001835-0s7ok4uw	3913	24	the	the	DT
cord-001835-0s7ok4uw	3913	25	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	3913	26	domain	domain	NN
cord-001835-0s7ok4uw	3913	27	of	of	IN
cord-001835-0s7ok4uw	3913	28	the	the	DT
cord-001835-0s7ok4uw	3913	29	platelet	platelet	NN
cord-001835-0s7ok4uw	3913	30	-	-	HYPH
cord-001835-0s7ok4uw	3913	31	derived	derive	VBN
cord-001835-0s7ok4uw	3913	32	growth	growth	NN
cord-001835-0s7ok4uw	3913	33	factor	factor	NN
cord-001835-0s7ok4uw	3913	34	b	b	NN
cord-001835-0s7ok4uw	3913	35	receptor	receptor	NN
cord-001835-0s7ok4uw	3913	36	(	(	-LRB-
cord-001835-0s7ok4uw	3913	37	PDGFbR	pdgfbr	NN
cord-001835-0s7ok4uw	3913	38	)	)	-RRB-
cord-001835-0s7ok4uw	3913	39	,	,	,
cord-001835-0s7ok4uw	3913	40	resulting	result	VBG
cord-001835-0s7ok4uw	3913	41	in	in	IN
cord-001835-0s7ok4uw	3913	42	ligandindependent	ligandindependent	NNP
cord-001835-0s7ok4uw	3913	43	receptor	receptor	NN
cord-001835-0s7ok4uw	3913	44	activation	activation	NN
cord-001835-0s7ok4uw	3913	45	and	and	CC
cord-001835-0s7ok4uw	3913	46	cell	cell	NN
cord-001835-0s7ok4uw	3913	47	transformation	transformation	NN
cord-001835-0s7ok4uw	3913	48	.	.	.
cord-001835-0s7ok4uw	3914	1	These	these	DT
cord-001835-0s7ok4uw	3914	2	studies	study	NNS
cord-001835-0s7ok4uw	3914	3	showed	show	VBD
cord-001835-0s7ok4uw	3914	4	that	that	IN
cord-001835-0s7ok4uw	3914	5	a	a	DT
cord-001835-0s7ok4uw	3914	6	free	free	RB
cord-001835-0s7ok4uw	3914	7	-	-	HYPH
cord-001835-0s7ok4uw	3914	8	standing	stand	VBG
cord-001835-0s7ok4uw	3914	9	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	3914	10	domain	domain	NN
cord-001835-0s7ok4uw	3914	11	could	could	MD
cord-001835-0s7ok4uw	3914	12	fold	fold	VB
cord-001835-0s7ok4uw	3914	13	properly	properly	RB
cord-001835-0s7ok4uw	3914	14	in	in	IN
cord-001835-0s7ok4uw	3914	15	cells	cell	NNS
cord-001835-0s7ok4uw	3914	16	and	and	CC
cord-001835-0s7ok4uw	3914	17	act	act	VB
cord-001835-0s7ok4uw	3914	18	in	in	IN
cord-001835-0s7ok4uw	3914	19	trans	trans	NNP
cord-001835-0s7ok4uw	3914	20	to	to	TO
cord-001835-0s7ok4uw	3914	21	modulate	modulate	VB
cord-001835-0s7ok4uw	3914	22	the	the	DT
cord-001835-0s7ok4uw	3914	23	activity	activity	NN
cord-001835-0s7ok4uw	3914	24	of	of	IN
cord-001835-0s7ok4uw	3914	25	a	a	DT
cord-001835-0s7ok4uw	3914	26	larger	large	JJR
cord-001835-0s7ok4uw	3914	27	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	3914	28	protein	protein	NN
cord-001835-0s7ok4uw	3914	29	target	target	NN
cord-001835-0s7ok4uw	3914	30	.	.	.
cord-001835-0s7ok4uw	3915	1	Because	because	IN
cord-001835-0s7ok4uw	3915	2	of	of	IN
cord-001835-0s7ok4uw	3915	3	the	the	DT
cord-001835-0s7ok4uw	3915	4	relative	relative	JJ
cord-001835-0s7ok4uw	3915	5	chemical	chemical	NN
cord-001835-0s7ok4uw	3915	6	simplicity	simplicity	NN
cord-001835-0s7ok4uw	3915	7	of	of	IN
cord-001835-0s7ok4uw	3915	8	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	3915	9	domains	domain	NNS
cord-001835-0s7ok4uw	3915	10	and	and	CC
cord-001835-0s7ok4uw	3915	11	this	this	DT
cord-001835-0s7ok4uw	3915	12	ability	ability	NN
cord-001835-0s7ok4uw	3915	13	to	to	TO
cord-001835-0s7ok4uw	3915	14	act	act	VB
cord-001835-0s7ok4uw	3915	15	even	even	RB
cord-001835-0s7ok4uw	3915	16	when	when	WRB
cord-001835-0s7ok4uw	3915	17	not	not	RB
cord-001835-0s7ok4uw	3915	18	linked	link	VBN
cord-001835-0s7ok4uw	3915	19	to	to	IN
cord-001835-0s7ok4uw	3915	20	more	more	RBR
cord-001835-0s7ok4uw	3915	21	complex	complex	JJ
cord-001835-0s7ok4uw	3915	22	soluble	soluble	JJ
cord-001835-0s7ok4uw	3915	23	protein	protein	NN
cord-001835-0s7ok4uw	3915	24	domains	domain	NNS
cord-001835-0s7ok4uw	3915	25	,	,	,
cord-001835-0s7ok4uw	3915	26	we	-PRON-	PRP
cord-001835-0s7ok4uw	3915	27	reasoned	reason	VBD
cord-001835-0s7ok4uw	3915	28	that	that	IN
cord-001835-0s7ok4uw	3915	29	short	short	JJ
cord-001835-0s7ok4uw	3915	30	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	3915	31	proteins	protein	NNS
cord-001835-0s7ok4uw	3915	32	could	could	MD
cord-001835-0s7ok4uw	3915	33	be	be	VB
cord-001835-0s7ok4uw	3915	34	used	use	VBN
cord-001835-0s7ok4uw	3915	35	to	to	TO
cord-001835-0s7ok4uw	3915	36	define	define	VB
cord-001835-0s7ok4uw	3915	37	the	the	DT
cord-001835-0s7ok4uw	3915	38	minimal	minimal	JJ
cord-001835-0s7ok4uw	3915	39	chemical	chemical	NN
cord-001835-0s7ok4uw	3915	40	diversity	diversity	NN
cord-001835-0s7ok4uw	3915	41	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	3915	42	to	to	TO
cord-001835-0s7ok4uw	3915	43	construct	construct	VB
cord-001835-0s7ok4uw	3915	44	biologically	biologically	RB
cord-001835-0s7ok4uw	3915	45	active	active	JJ
cord-001835-0s7ok4uw	3915	46	proteins	protein	NNS
cord-001835-0s7ok4uw	3915	47	.	.	.
cord-001835-0s7ok4uw	3916	1	To	to	TO
cord-001835-0s7ok4uw	3916	2	accomplish	accomplish	VB
cord-001835-0s7ok4uw	3916	3	this	this	DT
cord-001835-0s7ok4uw	3916	4	,	,	,
cord-001835-0s7ok4uw	3916	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3916	6	infected	infect	VBD
cord-001835-0s7ok4uw	3916	7	cultured	cultured	JJ
cord-001835-0s7ok4uw	3916	8	mouse	mouse	NN
cord-001835-0s7ok4uw	3916	9	cells	cell	NNS
cord-001835-0s7ok4uw	3916	10	with	with	IN
cord-001835-0s7ok4uw	3916	11	a	a	DT
cord-001835-0s7ok4uw	3916	12	retroviral	retroviral	JJ
cord-001835-0s7ok4uw	3916	13	library	library	NN
cord-001835-0s7ok4uw	3916	14	expressing	express	VBG
cord-001835-0s7ok4uw	3916	15	26-amino	26-amino	CD
cord-001835-0s7ok4uw	3916	16	acid	acid	NN
cord-001835-0s7ok4uw	3916	17	proteins	protein	NNS
cord-001835-0s7ok4uw	3916	18	consisting	consist	VBG
cord-001835-0s7ok4uw	3916	19	of	of	IN
cord-001835-0s7ok4uw	3916	20	an	an	DT
cord-001835-0s7ok4uw	3916	21	initiating	initiate	VBG
cord-001835-0s7ok4uw	3916	22	methionine	methionine	NN
cord-001835-0s7ok4uw	3916	23	followed	follow	VBN
cord-001835-0s7ok4uw	3916	24	by	by	IN
cord-001835-0s7ok4uw	3916	25	a	a	DT
cord-001835-0s7ok4uw	3916	26	randomized	randomized	JJ
cord-001835-0s7ok4uw	3916	27	sequence	sequence	NN
cord-001835-0s7ok4uw	3916	28	of	of	IN
cord-001835-0s7ok4uw	3916	29	leucines	leucine	NNS
cord-001835-0s7ok4uw	3916	30	and	and	CC
cord-001835-0s7ok4uw	3916	31	isoleucines	isoleucine	NNS
cord-001835-0s7ok4uw	3916	32	,	,	,
cord-001835-0s7ok4uw	3916	33	two	two	CD
cord-001835-0s7ok4uw	3916	34	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3916	35	amino	amino	NN
cord-001835-0s7ok4uw	3916	36	acids	acid	NNS
cord-001835-0s7ok4uw	3916	37	that	that	WDT
cord-001835-0s7ok4uw	3916	38	differ	differ	VBP
cord-001835-0s7ok4uw	3916	39	only	only	RB
cord-001835-0s7ok4uw	3916	40	by	by	IN
cord-001835-0s7ok4uw	3916	41	the	the	DT
cord-001835-0s7ok4uw	3916	42	position	position	NN
cord-001835-0s7ok4uw	3916	43	of	of	IN
cord-001835-0s7ok4uw	3916	44	a	a	DT
cord-001835-0s7ok4uw	3916	45	single	single	JJ
cord-001835-0s7ok4uw	3916	46	methyl	methyl	NN
cord-001835-0s7ok4uw	3916	47	group	group	NN
cord-001835-0s7ok4uw	3916	48	,	,	,
cord-001835-0s7ok4uw	3916	49	and	and	CC
cord-001835-0s7ok4uw	3916	50	selected	select	VBD
cord-001835-0s7ok4uw	3916	51	rare	rare	JJ
cord-001835-0s7ok4uw	3916	52	proteins	protein	NNS
cord-001835-0s7ok4uw	3916	53	with	with	IN
cord-001835-0s7ok4uw	3916	54	transforming	transform	VBG
cord-001835-0s7ok4uw	3916	55	activity	activity	NN
cord-001835-0s7ok4uw	3916	56	.	.	.
cord-001835-0s7ok4uw	3917	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3917	2	isolated	isolate	VBD
cord-001835-0s7ok4uw	3917	3	numerous	numerous	JJ
cord-001835-0s7ok4uw	3917	4	proteins	protein	NNS
cord-001835-0s7ok4uw	3917	5	consisting	consist	VBG
cord-001835-0s7ok4uw	3917	6	of	of	IN
cord-001835-0s7ok4uw	3917	7	diverse	diverse	JJ
cord-001835-0s7ok4uw	3917	8	sequences	sequence	NNS
cord-001835-0s7ok4uw	3917	9	of	of	IN
cord-001835-0s7ok4uw	3917	10	leucine	leucine	NN
cord-001835-0s7ok4uw	3917	11	and	and	CC
cord-001835-0s7ok4uw	3917	12	isoleucine	isoleucine	NN
cord-001835-0s7ok4uw	3917	13	that	that	WDT
cord-001835-0s7ok4uw	3917	14	cause	cause	VBP
cord-001835-0s7ok4uw	3917	15	morphologic	morphologic	JJ
cord-001835-0s7ok4uw	3917	16	transformation	transformation	NN
cord-001835-0s7ok4uw	3917	17	,	,	,
cord-001835-0s7ok4uw	3917	18	escape	escape	VB
cord-001835-0s7ok4uw	3917	19	from	from	IN
cord-001835-0s7ok4uw	3917	20	contact	contact	NN
cord-001835-0s7ok4uw	3917	21	inhibition	inhibition	NN
cord-001835-0s7ok4uw	3917	22	and	and	CC
cord-001835-0s7ok4uw	3917	23	focus	focus	NN
cord-001835-0s7ok4uw	3917	24	formation	formation	NN
cord-001835-0s7ok4uw	3917	25	,	,	,
cord-001835-0s7ok4uw	3917	26	and	and	CC
cord-001835-0s7ok4uw	3917	27	growth	growth	NN
cord-001835-0s7ok4uw	3917	28	factor	factor	NN
cord-001835-0s7ok4uw	3917	29	independence	independence	NN
cord-001835-0s7ok4uw	3917	30	.	.	.
cord-001835-0s7ok4uw	3918	1	Genetic	genetic	JJ
cord-001835-0s7ok4uw	3918	2	and	and	CC
cord-001835-0s7ok4uw	3918	3	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	3918	4	analysis	analysis	NN
cord-001835-0s7ok4uw	3918	5	of	of	IN
cord-001835-0s7ok4uw	3918	6	these	these	DT
cord-001835-0s7ok4uw	3918	7	proteins	protein	NNS
cord-001835-0s7ok4uw	3918	8	indicate	indicate	VBP
cord-001835-0s7ok4uw	3918	9	that	that	IN
cord-001835-0s7ok4uw	3918	10	like	like	UH
cord-001835-0s7ok4uw	3918	11	E5	E5	NNP
cord-001835-0s7ok4uw	3918	12	they	-PRON-	PRP
cord-001835-0s7ok4uw	3918	13	interact	interact	VBP
cord-001835-0s7ok4uw	3918	14	with	with	IN
cord-001835-0s7ok4uw	3918	15	the	the	DT
cord-001835-0s7ok4uw	3918	16	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	3918	17	domain	domain	NN
cord-001835-0s7ok4uw	3918	18	of	of	IN
cord-001835-0s7ok4uw	3918	19	the	the	DT
cord-001835-0s7ok4uw	3918	20	PDGFbR	PDGFbR	NNP
cord-001835-0s7ok4uw	3918	21	to	to	TO
cord-001835-0s7ok4uw	3918	22	specifically	specifically	RB
cord-001835-0s7ok4uw	3918	23	activate	activate	VB
cord-001835-0s7ok4uw	3918	24	the	the	DT
cord-001835-0s7ok4uw	3918	25	receptor	receptor	NN
cord-001835-0s7ok4uw	3918	26	and	and	CC
cord-001835-0s7ok4uw	3918	27	transform	transform	VB
cord-001835-0s7ok4uw	3918	28	cells	cell	NNS
cord-001835-0s7ok4uw	3918	29	.	.	.
cord-001835-0s7ok4uw	3919	1	Mutational	mutational	JJ
cord-001835-0s7ok4uw	3919	2	analysis	analysis	NN
cord-001835-0s7ok4uw	3919	3	of	of	IN
cord-001835-0s7ok4uw	3919	4	individual	individual	JJ
cord-001835-0s7ok4uw	3919	5	proteins	protein	NNS
cord-001835-0s7ok4uw	3919	6	identified	identify	VBD
cord-001835-0s7ok4uw	3919	7	specific	specific	JJ
cord-001835-0s7ok4uw	3919	8	leucines	leucine	NNS
cord-001835-0s7ok4uw	3919	9	and	and	CC
cord-001835-0s7ok4uw	3919	10	isoleucines	isoleucine	NNS
cord-001835-0s7ok4uw	3919	11	required	require	VBN
cord-001835-0s7ok4uw	3919	12	for	for	IN
cord-001835-0s7ok4uw	3919	13	transforming	transform	VBG
cord-001835-0s7ok4uw	3919	14	activity	activity	NN
cord-001835-0s7ok4uw	3919	15	,	,	,
cord-001835-0s7ok4uw	3919	16	and	and	CC
cord-001835-0s7ok4uw	3919	17	insertion	insertion	NN
cord-001835-0s7ok4uw	3919	18	of	of	IN
cord-001835-0s7ok4uw	3919	19	a	a	DT
cord-001835-0s7ok4uw	3919	20	single	single	JJ
cord-001835-0s7ok4uw	3919	21	isoleucine	isoleucine	NN
cord-001835-0s7ok4uw	3919	22	at	at	IN
cord-001835-0s7ok4uw	3919	23	a	a	DT
cord-001835-0s7ok4uw	3919	24	particular	particular	JJ
cord-001835-0s7ok4uw	3919	25	position	position	NN
cord-001835-0s7ok4uw	3919	26	in	in	IN
cord-001835-0s7ok4uw	3919	27	a	a	DT
cord-001835-0s7ok4uw	3919	28	stretch	stretch	NN
cord-001835-0s7ok4uw	3919	29	of	of	IN
cord-001835-0s7ok4uw	3919	30	leucines	leucine	NNS
cord-001835-0s7ok4uw	3919	31	is	be	VBZ
cord-001835-0s7ok4uw	3919	32	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	3919	33	for	for	IN
cord-001835-0s7ok4uw	3919	34	activity	activity	NN
cord-001835-0s7ok4uw	3919	35	.	.	.
cord-001835-0s7ok4uw	3920	1	These	these	DT
cord-001835-0s7ok4uw	3920	2	proteins	protein	NNS
cord-001835-0s7ok4uw	3920	3	identify	identify	VBP
cord-001835-0s7ok4uw	3920	4	the	the	DT
cord-001835-0s7ok4uw	3920	5	minimal	minimal	JJ
cord-001835-0s7ok4uw	3920	6	chemical	chemical	NN
cord-001835-0s7ok4uw	3920	7	diversity	diversity	NN
cord-001835-0s7ok4uw	3920	8	required	require	VBN
cord-001835-0s7ok4uw	3920	9	to	to	TO
cord-001835-0s7ok4uw	3920	10	generate	generate	VB
cord-001835-0s7ok4uw	3920	11	a	a	DT
cord-001835-0s7ok4uw	3920	12	biologically	biologically	RB
cord-001835-0s7ok4uw	3920	13	active	active	JJ
cord-001835-0s7ok4uw	3920	14	protein	protein	NN
cord-001835-0s7ok4uw	3920	15	and	and	CC
cord-001835-0s7ok4uw	3920	16	have	have	VBP
cord-001835-0s7ok4uw	3920	17	important	important	JJ
cord-001835-0s7ok4uw	3920	18	implications	implication	NNS
cord-001835-0s7ok4uw	3920	19	for	for	IN
cord-001835-0s7ok4uw	3920	20	biochemistry	biochemistry	NN
cord-001835-0s7ok4uw	3920	21	,	,	,
cord-001835-0s7ok4uw	3920	22	protein	protein	NN
cord-001835-0s7ok4uw	3920	23	evolution	evolution	NN
cord-001835-0s7ok4uw	3920	24	,	,	,
cord-001835-0s7ok4uw	3920	25	protein	protein	NN
cord-001835-0s7ok4uw	3920	26	engineering	engineering	NN
cord-001835-0s7ok4uw	3920	27	and	and	CC
cord-001835-0s7ok4uw	3920	28	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	3920	29	biology	biology	NN
cord-001835-0s7ok4uw	3920	30	.	.	.
cord-001835-0s7ok4uw	3921	1	Yusuke	Yusuke	NNP
cord-001835-0s7ok4uw	3921	2	Azuma	Azuma	NNP
cord-001835-0s7ok4uw	3921	3	1	1	CD
cord-001835-0s7ok4uw	3921	4	,	,	,
cord-001835-0s7ok4uw	3921	5	Donald	Donald	NNP
cord-001835-0s7ok4uw	3921	6	Hilvert	Hilvert	NNP
cord-001835-0s7ok4uw	3921	7	1	1	CD
cord-001835-0s7ok4uw	3921	8	1	1	CD
cord-001835-0s7ok4uw	3921	9	Virus	Virus	NNP
cord-001835-0s7ok4uw	3921	10	-	-	HYPH
cord-001835-0s7ok4uw	3921	11	like	like	JJ
cord-001835-0s7ok4uw	3921	12	particles	particle	NNS
cord-001835-0s7ok4uw	3921	13	that	that	WDT
cord-001835-0s7ok4uw	3921	14	are	be	VBP
cord-001835-0s7ok4uw	3921	15	precisely	precisely	RB
cord-001835-0s7ok4uw	3921	16	loaded	load	VBN
cord-001835-0s7ok4uw	3921	17	with	with	IN
cord-001835-0s7ok4uw	3921	18	functional	functional	JJ
cord-001835-0s7ok4uw	3921	19	cargo	cargo	NN
cord-001835-0s7ok4uw	3921	20	are	be	VBP
cord-001835-0s7ok4uw	3921	21	an	an	DT
cord-001835-0s7ok4uw	3921	22	important	important	JJ
cord-001835-0s7ok4uw	3921	23	tool	tool	NN
cord-001835-0s7ok4uw	3921	24	to	to	TO
cord-001835-0s7ok4uw	3921	25	study	study	VB
cord-001835-0s7ok4uw	3921	26	the	the	DT
cord-001835-0s7ok4uw	3921	27	effect	effect	NN
cord-001835-0s7ok4uw	3921	28	of	of	IN
cord-001835-0s7ok4uw	3921	29	spatial	spatial	JJ
cord-001835-0s7ok4uw	3921	30	confinement	confinement	NN
cord-001835-0s7ok4uw	3921	31	and	and	CC
cord-001835-0s7ok4uw	3921	32	create	create	VB
cord-001835-0s7ok4uw	3921	33	novel	novel	JJ
cord-001835-0s7ok4uw	3921	34	entities	entity	NNS
cord-001835-0s7ok4uw	3921	35	with	with	IN
cord-001835-0s7ok4uw	3921	36	application	application	NN
cord-001835-0s7ok4uw	3921	37	in	in	IN
cord-001835-0s7ok4uw	3921	38	biotechnology	biotechnology	NN
cord-001835-0s7ok4uw	3921	39	and	and	CC
cord-001835-0s7ok4uw	3921	40	medicine	medicine	NN
cord-001835-0s7ok4uw	3921	41	.	.	.
cord-001835-0s7ok4uw	3922	1	By	by	IN
cord-001835-0s7ok4uw	3922	2	genetic	genetic	JJ
cord-001835-0s7ok4uw	3922	3	fusion	fusion	NN
cord-001835-0s7ok4uw	3922	4	to	to	IN
cord-001835-0s7ok4uw	3922	5	a	a	DT
cord-001835-0s7ok4uw	3922	6	positively	positively	RB
cord-001835-0s7ok4uw	3922	7	supercharged	supercharge	VBN
cord-001835-0s7ok4uw	3922	8	green	green	JJ
cord-001835-0s7ok4uw	3922	9	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	3922	10	protein	protein	NN
cord-001835-0s7ok4uw	3922	11	(	(	-LRB-
cord-001835-0s7ok4uw	3922	12	GFP(136	GFP(136	NNS
cord-001835-0s7ok4uw	3922	13	)	)	-RRB-
cord-001835-0s7ok4uw	3922	14	)	)	-RRB-
cord-001835-0s7ok4uw	3922	15	,	,	,
cord-001835-0s7ok4uw	3922	16	an	an	DT
cord-001835-0s7ok4uw	3922	17	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3922	18	retroaldolase	retroaldolase	NN
cord-001835-0s7ok4uw	3922	19	(	(	-LRB-
cord-001835-0s7ok4uw	3922	20	RA	RA	NNP
cord-001835-0s7ok4uw	3922	21	)	)	-RRB-
cord-001835-0s7ok4uw	3922	22	was	be	VBD
cord-001835-0s7ok4uw	3922	23	efficiently	efficiently	RB
cord-001835-0s7ok4uw	3922	24	targeted	target	VBN
cord-001835-0s7ok4uw	3922	25	to	to	IN
cord-001835-0s7ok4uw	3922	26	the	the	DT
cord-001835-0s7ok4uw	3922	27	negatively	negatively	RB
cord-001835-0s7ok4uw	3922	28	charged	charge	VBN
cord-001835-0s7ok4uw	3922	29	lumen	lumen	NN
cord-001835-0s7ok4uw	3922	30	of	of	IN
cord-001835-0s7ok4uw	3922	31	an	an	DT
cord-001835-0s7ok4uw	3922	32	engineered	engineer	VBN
cord-001835-0s7ok4uw	3922	33	protein	protein	NN
cord-001835-0s7ok4uw	3922	34	cage	cage	NN
cord-001835-0s7ok4uw	3922	35	,	,	,
cord-001835-0s7ok4uw	3922	36	Aquifex	Aquifex	NNP
cord-001835-0s7ok4uw	3922	37	aeolicus	aeolicus	NNP
cord-001835-0s7ok4uw	3922	38	lumazine	lumazine	NNP
cord-001835-0s7ok4uw	3922	39	synthase	synthase	NNP
cord-001835-0s7ok4uw	3922	40	variant	variant	NN
cord-001835-0s7ok4uw	3922	41	13	13	CD
cord-001835-0s7ok4uw	3922	42	(	(	-LRB-
cord-001835-0s7ok4uw	3922	43	AaLS-13	aals-13	NN
cord-001835-0s7ok4uw	3922	44	)	)	-RRB-
cord-001835-0s7ok4uw	3922	45	.	.	.
cord-001835-0s7ok4uw	3923	1	The	the	DT
cord-001835-0s7ok4uw	3923	2	encapsulation	encapsulation	NN
cord-001835-0s7ok4uw	3923	3	is	be	VBZ
cord-001835-0s7ok4uw	3923	4	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	3923	5	under	under	IN
cord-001835-0s7ok4uw	3923	6	mild	mild	JJ
cord-001835-0s7ok4uw	3923	7	aqueous	aqueous	JJ
cord-001835-0s7ok4uw	3923	8	condition	condition	NN
cord-001835-0s7ok4uw	3923	9	up	up	IN
cord-001835-0s7ok4uw	3923	10	to	to	IN
cord-001835-0s7ok4uw	3923	11	a	a	DT
cord-001835-0s7ok4uw	3923	12	mixing	mix	VBG
cord-001835-0s7ok4uw	3923	13	ratio	ratio	NN
cord-001835-0s7ok4uw	3923	14	of	of	IN
cord-001835-0s7ok4uw	3923	15	45	45	CD
cord-001835-0s7ok4uw	3923	16	guest	guest	NN
cord-001835-0s7ok4uw	3923	17	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3923	18	per	per	IN
cord-001835-0s7ok4uw	3923	19	host	host	NN
cord-001835-0s7ok4uw	3923	20	cages	cage	NNS
cord-001835-0s7ok4uw	3923	21	.	.	.
cord-001835-0s7ok4uw	3924	1	The	the	DT
cord-001835-0s7ok4uw	3924	2	chromophoric	chromophoric	JJ
cord-001835-0s7ok4uw	3924	3	tag	tag	NN
cord-001835-0s7ok4uw	3924	4	is	be	VBZ
cord-001835-0s7ok4uw	3924	5	used	use	VBN
cord-001835-0s7ok4uw	3924	6	for	for	IN
cord-001835-0s7ok4uw	3924	7	precisely	precisely	RB
cord-001835-0s7ok4uw	3924	8	quantifying	quantify	VBG
cord-001835-0s7ok4uw	3924	9	the	the	DT
cord-001835-0s7ok4uw	3924	10	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3924	11	concentration	concentration	NN
cord-001835-0s7ok4uw	3924	12	,	,	,
cord-001835-0s7ok4uw	3924	13	which	which	WDT
cord-001835-0s7ok4uw	3924	14	allows	allow	VBZ
cord-001835-0s7ok4uw	3924	15	detailed	detailed	JJ
cord-001835-0s7ok4uw	3924	16	characterization	characterization	NN
cord-001835-0s7ok4uw	3924	17	of	of	IN
cord-001835-0s7ok4uw	3924	18	the	the	DT
cord-001835-0s7ok4uw	3924	19	effect	effect	NN
cord-001835-0s7ok4uw	3924	20	of	of	IN
cord-001835-0s7ok4uw	3924	21	encapsulation	encapsulation	NN
cord-001835-0s7ok4uw	3924	22	on	on	IN
cord-001835-0s7ok4uw	3924	23	the	the	DT
cord-001835-0s7ok4uw	3924	24	enzyme	enzyme	NN
cord-001835-0s7ok4uw	3924	25	activity	activity	NN
cord-001835-0s7ok4uw	3924	26	.	.	.
cord-001835-0s7ok4uw	3925	1	The	the	DT
cord-001835-0s7ok4uw	3925	2	generality	generality	NN
cord-001835-0s7ok4uw	3925	3	of	of	IN
cord-001835-0s7ok4uw	3925	4	the	the	DT
cord-001835-0s7ok4uw	3925	5	encapsulation	encapsulation	NN
cord-001835-0s7ok4uw	3925	6	system	system	NN
cord-001835-0s7ok4uw	3925	7	was	be	VBD
cord-001835-0s7ok4uw	3925	8	examined	examine	VBN
cord-001835-0s7ok4uw	3925	9	with	with	IN
cord-001835-0s7ok4uw	3925	10	8	8	CD
cord-001835-0s7ok4uw	3925	11	structurally	structurally	RB
cord-001835-0s7ok4uw	3925	12	different	different	JJ
cord-001835-0s7ok4uw	3925	13	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	3925	14	.	.	.
cord-001835-0s7ok4uw	3926	1	Introduction	introduction	NN
cord-001835-0s7ok4uw	3926	2	and	and	CC
cord-001835-0s7ok4uw	3926	3	purpose	purpose	NN
cord-001835-0s7ok4uw	3926	4	:	:	:
cord-001835-0s7ok4uw	3926	5	In	in	IN
cord-001835-0s7ok4uw	3926	6	the	the	DT
cord-001835-0s7ok4uw	3926	7	immune	immune	JJ
cord-001835-0s7ok4uw	3926	8	system	system	NN
cord-001835-0s7ok4uw	3926	9	,	,	,
cord-001835-0s7ok4uw	3926	10	high	high	JJ
cord-001835-0s7ok4uw	3926	11	affinity	affinity	NN
cord-001835-0s7ok4uw	3926	12	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3926	13	are	be	VBP
cord-001835-0s7ok4uw	3926	14	generated	generate	VBN
cord-001835-0s7ok4uw	3926	15	by	by	IN
cord-001835-0s7ok4uw	3926	16	selection	selection	NN
cord-001835-0s7ok4uw	3926	17	of	of	IN
cord-001835-0s7ok4uw	3926	18	B	b	NN
cord-001835-0s7ok4uw	3926	19	cells	cell	NNS
cord-001835-0s7ok4uw	3926	20	activated	activate	VBN
cord-001835-0s7ok4uw	3926	21	by	by	IN
cord-001835-0s7ok4uw	3926	22	antigen	antigen	NN
cord-001835-0s7ok4uw	3926	23	-	-	HYPH
cord-001835-0s7ok4uw	3926	24	stimulation	stimulation	NN
cord-001835-0s7ok4uw	3926	25	followed	follow	VBN
cord-001835-0s7ok4uw	3926	26	by	by	IN
cord-001835-0s7ok4uw	3926	27	additional	additional	JJ
cord-001835-0s7ok4uw	3926	28	optimization	optimization	NN
cord-001835-0s7ok4uw	3926	29	through	through	IN
cord-001835-0s7ok4uw	3926	30	somatic	somatic	JJ
cord-001835-0s7ok4uw	3926	31	hyper	hyper	JJ
cord-001835-0s7ok4uw	3926	32	mutation	mutation	NN
cord-001835-0s7ok4uw	3926	33	of	of	IN
cord-001835-0s7ok4uw	3926	34	antibody	antibody	NN
cord-001835-0s7ok4uw	3926	35	genes	gene	NNS
cord-001835-0s7ok4uw	3926	36	.	.	.
cord-001835-0s7ok4uw	3927	1	In	in	IN
cord-001835-0s7ok4uw	3927	2	the	the	DT
cord-001835-0s7ok4uw	3927	3	artificial	artificial	JJ
cord-001835-0s7ok4uw	3927	4	antibody	antibody	NN
cord-001835-0s7ok4uw	3927	5	libraries	library	NNS
cord-001835-0s7ok4uw	3927	6	,	,	,
cord-001835-0s7ok4uw	3927	7	such	such	JJ
cord-001835-0s7ok4uw	3927	8	as	as	IN
cord-001835-0s7ok4uw	3927	9	phage	phage	NN
cord-001835-0s7ok4uw	3927	10	libraries	library	NNS
cord-001835-0s7ok4uw	3927	11	,	,	,
cord-001835-0s7ok4uw	3927	12	selection	selection	NN
cord-001835-0s7ok4uw	3927	13	of	of	IN
cord-001835-0s7ok4uw	3927	14	specific	specific	JJ
cord-001835-0s7ok4uw	3927	15	antibody	antibody	NN
cord-001835-0s7ok4uw	3927	16	clones	clone	NNS
cord-001835-0s7ok4uw	3927	17	from	from	IN
cord-001835-0s7ok4uw	3927	18	the	the	DT
cord-001835-0s7ok4uw	3927	19	library	library	NN
cord-001835-0s7ok4uw	3927	20	is	be	VBZ
cord-001835-0s7ok4uw	3927	21	performed	perform	VBN
cord-001835-0s7ok4uw	3927	22	by	by	IN
cord-001835-0s7ok4uw	3927	23	in	in	FW
cord-001835-0s7ok4uw	3927	24	vitro	vitro	FW
cord-001835-0s7ok4uw	3927	25	selection	selection	NN
cord-001835-0s7ok4uw	3927	26	process	process	NN
cord-001835-0s7ok4uw	3927	27	called	call	VBN
cord-001835-0s7ok4uw	3927	28	biopanning	biopanning	NN
cord-001835-0s7ok4uw	3927	29	and	and	CC
cord-001835-0s7ok4uw	3927	30	the	the	DT
cord-001835-0s7ok4uw	3927	31	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	3927	32	binding	binding	NN
cord-001835-0s7ok4uw	3927	33	screening	screening	NN
cord-001835-0s7ok4uw	3927	34	.	.	.
cord-001835-0s7ok4uw	3928	1	However	however	RB
cord-001835-0s7ok4uw	3928	2	,	,	,
cord-001835-0s7ok4uw	3928	3	in	in	IN
cord-001835-0s7ok4uw	3928	4	spite	spite	NN
cord-001835-0s7ok4uw	3928	5	of	of	IN
cord-001835-0s7ok4uw	3928	6	high	high	JJ
cord-001835-0s7ok4uw	3928	7	efficiency	efficiency	NN
cord-001835-0s7ok4uw	3928	8	of	of	IN
cord-001835-0s7ok4uw	3928	9	enrichment	enrichment	NN
cord-001835-0s7ok4uw	3928	10	in	in	IN
cord-001835-0s7ok4uw	3928	11	biopanning	biopanning	NN
cord-001835-0s7ok4uw	3928	12	,	,	,
cord-001835-0s7ok4uw	3928	13	there	there	EX
cord-001835-0s7ok4uw	3928	14	is	be	VBZ
cord-001835-0s7ok4uw	3928	15	a	a	DT
cord-001835-0s7ok4uw	3928	16	possibility	possibility	NN
cord-001835-0s7ok4uw	3928	17	that	that	IN
cord-001835-0s7ok4uw	3928	18	we	-PRON-	PRP
cord-001835-0s7ok4uw	3928	19	overlook	overlook	VBP
cord-001835-0s7ok4uw	3928	20	the	the	DT
cord-001835-0s7ok4uw	3928	21	minor	minor	JJ
cord-001835-0s7ok4uw	3928	22	antigen	antigen	NN
cord-001835-0s7ok4uw	3928	23	-	-	HYPH
cord-001835-0s7ok4uw	3928	24	specific	specific	JJ
cord-001835-0s7ok4uw	3928	25	clones	clone	NNS
cord-001835-0s7ok4uw	3928	26	in	in	IN
cord-001835-0s7ok4uw	3928	27	the	the	DT
cord-001835-0s7ok4uw	3928	28	screening	screening	NN
cord-001835-0s7ok4uw	3928	29	because	because	IN
cord-001835-0s7ok4uw	3928	30	of	of	IN
cord-001835-0s7ok4uw	3928	31	the	the	DT
cord-001835-0s7ok4uw	3928	32	limitation	limitation	NN
cord-001835-0s7ok4uw	3928	33	of	of	IN
cord-001835-0s7ok4uw	3928	34	the	the	DT
cord-001835-0s7ok4uw	3928	35	number	number	NN
cord-001835-0s7ok4uw	3928	36	of	of	IN
cord-001835-0s7ok4uw	3928	37	clones	clone	NNS
cord-001835-0s7ok4uw	3928	38	employed	employ	VBN
cord-001835-0s7ok4uw	3928	39	for	for	IN
cord-001835-0s7ok4uw	3928	40	screening	screening	NN
cord-001835-0s7ok4uw	3928	41	.	.	.
cord-001835-0s7ok4uw	3929	1	In	in	IN
cord-001835-0s7ok4uw	3929	2	recent	recent	JJ
cord-001835-0s7ok4uw	3929	3	years	year	NNS
cord-001835-0s7ok4uw	3929	4	,	,	,
cord-001835-0s7ok4uw	3929	5	high	high	JJ
cord-001835-0s7ok4uw	3929	6	-	-	HYPH
cord-001835-0s7ok4uw	3929	7	throughput	throughput	NN
cord-001835-0s7ok4uw	3929	8	analysis	analysis	NN
cord-001835-0s7ok4uw	3929	9	of	of	IN
cord-001835-0s7ok4uw	3929	10	DNA	dna	NN
cord-001835-0s7ok4uw	3929	11	sequences	sequence	NNS
cord-001835-0s7ok4uw	3929	12	by	by	IN
cord-001835-0s7ok4uw	3929	13	the	the	DT
cord-001835-0s7ok4uw	3929	14	next	next	JJ
cord-001835-0s7ok4uw	3929	15	-	-	HYPH
cord-001835-0s7ok4uw	3929	16	generation	generation	NN
cord-001835-0s7ok4uw	3929	17	sequencer	sequencer	NN
cord-001835-0s7ok4uw	3929	18	(	(	-LRB-
cord-001835-0s7ok4uw	3929	19	NGS	NGS	NNP
cord-001835-0s7ok4uw	3929	20	)	)	-RRB-
cord-001835-0s7ok4uw	3929	21	has	have	VBZ
cord-001835-0s7ok4uw	3929	22	become	become	VBN
cord-001835-0s7ok4uw	3929	23	available	available	JJ
cord-001835-0s7ok4uw	3929	24	not	not	RB
cord-001835-0s7ok4uw	3929	25	only	only	RB
cord-001835-0s7ok4uw	3929	26	for	for	IN
cord-001835-0s7ok4uw	3929	27	genomic	genomic	JJ
cord-001835-0s7ok4uw	3929	28	analysis	analysis	NN
cord-001835-0s7ok4uw	3929	29	of	of	IN
cord-001835-0s7ok4uw	3929	30	organisms	organism	NNS
cord-001835-0s7ok4uw	3929	31	but	but	CC
cord-001835-0s7ok4uw	3929	32	also	also	RB
cord-001835-0s7ok4uw	3929	33	repertoire	repertoire	NN
cord-001835-0s7ok4uw	3929	34	analysis	analysis	NN
cord-001835-0s7ok4uw	3929	35	of	of	IN
cord-001835-0s7ok4uw	3929	36	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3929	37	.	.	.
cord-001835-0s7ok4uw	3930	1	In	in	IN
cord-001835-0s7ok4uw	3930	2	this	this	DT
cord-001835-0s7ok4uw	3930	3	presentation	presentation	NN
cord-001835-0s7ok4uw	3930	4	,	,	,
cord-001835-0s7ok4uw	3930	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3930	6	report	report	VBP
cord-001835-0s7ok4uw	3930	7	the	the	DT
cord-001835-0s7ok4uw	3930	8	successful	successful	JJ
cord-001835-0s7ok4uw	3930	9	isolation	isolation	NN
cord-001835-0s7ok4uw	3930	10	of	of	IN
cord-001835-0s7ok4uw	3930	11	a	a	DT
cord-001835-0s7ok4uw	3930	12	variety	variety	NN
cord-001835-0s7ok4uw	3930	13	of	of	IN
cord-001835-0s7ok4uw	3930	14	antigen	antigen	NN
cord-001835-0s7ok4uw	3930	15	specific	specific	JJ
cord-001835-0s7ok4uw	3930	16	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3930	17	from	from	IN
cord-001835-0s7ok4uw	3930	18	patients	patient	NNS
cord-001835-0s7ok4uw	3930	19	-	-	HYPH
cord-001835-0s7ok4uw	3930	20	derived	derive	VBN
cord-001835-0s7ok4uw	3930	21	antibody	antibody	NN
cord-001835-0s7ok4uw	3930	22	phage	phage	NN
cord-001835-0s7ok4uw	3930	23	library	library	NN
cord-001835-0s7ok4uw	3930	24	by	by	IN
cord-001835-0s7ok4uw	3930	25	a	a	DT
cord-001835-0s7ok4uw	3930	26	combination	combination	NN
cord-001835-0s7ok4uw	3930	27	method	method	NN
cord-001835-0s7ok4uw	3930	28	of	of	IN
cord-001835-0s7ok4uw	3930	29	high	high	JJ
cord-001835-0s7ok4uw	3930	30	throughput	throughput	NN
cord-001835-0s7ok4uw	3930	31	sequence	sequence	NN
cord-001835-0s7ok4uw	3930	32	analysis	analysis	NN
cord-001835-0s7ok4uw	3930	33	on	on	IN
cord-001835-0s7ok4uw	3930	34	NGS	NGS	NNP
cord-001835-0s7ok4uw	3930	35	and	and	CC
cord-001835-0s7ok4uw	3930	36	biopanning	biopanning	NN
cord-001835-0s7ok4uw	3930	37	.	.	.
cord-001835-0s7ok4uw	3931	1	Method	method	NN
cord-001835-0s7ok4uw	3931	2	:	:	:
cord-001835-0s7ok4uw	3932	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3932	2	constructed	construct	VBD
cord-001835-0s7ok4uw	3932	3	two	two	CD
cord-001835-0s7ok4uw	3932	4	kinds	kind	NNS
cord-001835-0s7ok4uw	3932	5	of	of	IN
cord-001835-0s7ok4uw	3932	6	human	human	JJ
cord-001835-0s7ok4uw	3932	7	single	single	JJ
cord-001835-0s7ok4uw	3932	8	chain	chain	NN
cord-001835-0s7ok4uw	3932	9	Fv	Fv	NNP
cord-001835-0s7ok4uw	3932	10	(	(	-LRB-
cord-001835-0s7ok4uw	3932	11	scFv	scFv	NNP
cord-001835-0s7ok4uw	3932	12	)	)	-RRB-
cord-001835-0s7ok4uw	3932	13	antibody	antibody	NN
cord-001835-0s7ok4uw	3932	14	libraries	library	NNS
cord-001835-0s7ok4uw	3932	15	from	from	IN
cord-001835-0s7ok4uw	3932	16	pooled	pool	VBN
cord-001835-0s7ok4uw	3932	17	mRNA	mrna	NN
cord-001835-0s7ok4uw	3932	18	of	of	IN
cord-001835-0s7ok4uw	3932	19	five	five	CD
cord-001835-0s7ok4uw	3932	20	cancer	cancer	NN
cord-001835-0s7ok4uw	3932	21	patients	patient	NNS
cord-001835-0s7ok4uw	3932	22	and	and	CC
cord-001835-0s7ok4uw	3932	23	of	of	IN
cord-001835-0s7ok4uw	3932	24	a	a	DT
cord-001835-0s7ok4uw	3932	25	wheat	wheat	NN
cord-001835-0s7ok4uw	3932	26	allergy	allergy	NN
cord-001835-0s7ok4uw	3932	27	patient	patient	NN
cord-001835-0s7ok4uw	3932	28	,	,	,
cord-001835-0s7ok4uw	3932	29	respectively	respectively	RB
cord-001835-0s7ok4uw	3932	30	.	.	.
cord-001835-0s7ok4uw	3933	1	After	after	IN
cord-001835-0s7ok4uw	3933	2	biopanning	biopanne	VBG
cord-001835-0s7ok4uw	3933	3	against	against	IN
cord-001835-0s7ok4uw	3933	4	a	a	DT
cord-001835-0s7ok4uw	3933	5	cancer	cancer	NN
cord-001835-0s7ok4uw	3933	6	antigen	antigen	NN
cord-001835-0s7ok4uw	3933	7	or	or	CC
cord-001835-0s7ok4uw	3933	8	wheat	wheat	NN
cord-001835-0s7ok4uw	3933	9	allergy	allergy	NN
cord-001835-0s7ok4uw	3933	10	antigen	antigen	NN
cord-001835-0s7ok4uw	3933	11	"	"	``
cord-001835-0s7ok4uw	3933	12	gluten	gluten	NN
cord-001835-0s7ok4uw	3933	13	"	"	''
cord-001835-0s7ok4uw	3933	14	,	,	,
cord-001835-0s7ok4uw	3933	15	the	the	DT
cord-001835-0s7ok4uw	3933	16	phagemid	phagemid	NN
cord-001835-0s7ok4uw	3933	17	vector	vector	NN
cord-001835-0s7ok4uw	3933	18	DNA	DNA	NNP
cord-001835-0s7ok4uw	3933	19	prepared	prepare	VBN
cord-001835-0s7ok4uw	3933	20	from	from	IN
cord-001835-0s7ok4uw	3933	21	the	the	DT
cord-001835-0s7ok4uw	3933	22	pooled	pool	VBN
cord-001835-0s7ok4uw	3933	23	phages	phage	NNS
cord-001835-0s7ok4uw	3933	24	before	before	IN
cord-001835-0s7ok4uw	3933	25	or	or	CC
cord-001835-0s7ok4uw	3933	26	after	after	IN
cord-001835-0s7ok4uw	3933	27	biopanning	biopanning	NN
cord-001835-0s7ok4uw	3933	28	was	be	VBD
cord-001835-0s7ok4uw	3933	29	used	use	VBN
cord-001835-0s7ok4uw	3933	30	for	for	IN
cord-001835-0s7ok4uw	3933	31	PCR	PCR	NNP
cord-001835-0s7ok4uw	3933	32	amplifications	amplification	NNS
cord-001835-0s7ok4uw	3933	33	of	of	IN
cord-001835-0s7ok4uw	3933	34	VH	VH	NNP
cord-001835-0s7ok4uw	3933	35	genes	gene	NNS
cord-001835-0s7ok4uw	3933	36	,	,	,
cord-001835-0s7ok4uw	3933	37	adding	add	VBG
cord-001835-0s7ok4uw	3933	38	the	the	DT
cord-001835-0s7ok4uw	3933	39	index	index	NN
cord-001835-0s7ok4uw	3933	40	and	and	CC
cord-001835-0s7ok4uw	3933	41	adapter	adapter	NN
cord-001835-0s7ok4uw	3933	42	sequences	sequence	NNS
cord-001835-0s7ok4uw	3933	43	for	for	IN
cord-001835-0s7ok4uw	3933	44	NGS	NGS	NNP
cord-001835-0s7ok4uw	3933	45	analysis	analysis	NN
cord-001835-0s7ok4uw	3933	46	.	.	.
cord-001835-0s7ok4uw	3934	1	The	the	DT
cord-001835-0s7ok4uw	3934	2	high	high	JJ
cord-001835-0s7ok4uw	3934	3	throughput	throughput	NN
cord-001835-0s7ok4uw	3934	4	sequencing	sequencing	NN
cord-001835-0s7ok4uw	3934	5	was	be	VBD
cord-001835-0s7ok4uw	3934	6	performed	perform	VBN
cord-001835-0s7ok4uw	3934	7	on	on	IN
cord-001835-0s7ok4uw	3934	8	Miseq	Miseq	NNP
cord-001835-0s7ok4uw	3934	9	(	(	-LRB-
cord-001835-0s7ok4uw	3934	10	illumina	illumina	NNP
cord-001835-0s7ok4uw	3934	11	)	)	-RRB-
cord-001835-0s7ok4uw	3934	12	using	use	VBG
cord-001835-0s7ok4uw	3934	13	MiSeq	MiSeq	NNP
cord-001835-0s7ok4uw	3934	14	Reagent	Reagent	NNP
cord-001835-0s7ok4uw	3934	15	Kits	kit	NNS
cord-001835-0s7ok4uw	3934	16	v3	v3	NN
cord-001835-0s7ok4uw	3934	17	.	.	.
cord-001835-0s7ok4uw	3935	1	After	after	IN
cord-001835-0s7ok4uw	3935	2	discarding	discard	VBG
cord-001835-0s7ok4uw	3935	3	the	the	DT
cord-001835-0s7ok4uw	3935	4	short	short	JJ
cord-001835-0s7ok4uw	3935	5	sequences	sequence	NNS
cord-001835-0s7ok4uw	3935	6	and	and	CC
cord-001835-0s7ok4uw	3935	7	low	low	JJ
cord-001835-0s7ok4uw	3935	8	quality	quality	NN
cord-001835-0s7ok4uw	3935	9	data	datum	NNS
cord-001835-0s7ok4uw	3935	10	,	,	,
cord-001835-0s7ok4uw	3935	11	5'-and	5'-and	CD
cord-001835-0s7ok4uw	3935	12	3'-reading	3'-reading	NN
cord-001835-0s7ok4uw	3935	13	sequences	sequence	NNS
cord-001835-0s7ok4uw	3935	14	were	be	VBD
cord-001835-0s7ok4uw	3935	15	unified	unify	VBN
cord-001835-0s7ok4uw	3935	16	by	by	IN
cord-001835-0s7ok4uw	3935	17	a	a	DT
cord-001835-0s7ok4uw	3935	18	Merge	merge	NN
cord-001835-0s7ok4uw	3935	19	program	program	NN
cord-001835-0s7ok4uw	3935	20	.	.	.
cord-001835-0s7ok4uw	3936	1	The	the	DT
cord-001835-0s7ok4uw	3936	2	frequencies	frequency	NNS
cord-001835-0s7ok4uw	3936	3	(	(	-LRB-
cord-001835-0s7ok4uw	3936	4	%	%	NN
cord-001835-0s7ok4uw	3936	5	)	)	-RRB-
cord-001835-0s7ok4uw	3936	6	of	of	IN
cord-001835-0s7ok4uw	3936	7	all	all	DT
cord-001835-0s7ok4uw	3936	8	VH	VH	NNP
cord-001835-0s7ok4uw	3936	9	sequences	sequence	NNS
cord-001835-0s7ok4uw	3936	10	were	be	VBD
cord-001835-0s7ok4uw	3936	11	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	3936	12	using	use	VBG
cord-001835-0s7ok4uw	3936	13	a	a	DT
cord-001835-0s7ok4uw	3936	14	program	program	NN
cord-001835-0s7ok4uw	3936	15	based	base	VBN
cord-001835-0s7ok4uw	3936	16	on	on	IN
cord-001835-0s7ok4uw	3936	17	Usearch	Usearch	NNP
cord-001835-0s7ok4uw	3936	18	8.0	8.0	CD
cord-001835-0s7ok4uw	3936	19	clustering	clustering	NN
cord-001835-0s7ok4uw	3936	20	software	software	NN
cord-001835-0s7ok4uw	3936	21	and	and	CC
cord-001835-0s7ok4uw	3936	22	the	the	DT
cord-001835-0s7ok4uw	3936	23	changes	change	NNS
cord-001835-0s7ok4uw	3936	24	of	of	IN
cord-001835-0s7ok4uw	3936	25	the	the	DT
cord-001835-0s7ok4uw	3936	26	frequency	frequency	NN
cord-001835-0s7ok4uw	3936	27	(	(	-LRB-
cord-001835-0s7ok4uw	3936	28	%	%	NN
cord-001835-0s7ok4uw	3936	29	)	)	-RRB-
cord-001835-0s7ok4uw	3936	30	of	of	IN
cord-001835-0s7ok4uw	3936	31	each	each	DT
cord-001835-0s7ok4uw	3936	32	sequence	sequence	NN
cord-001835-0s7ok4uw	3936	33	between	between	IN
cord-001835-0s7ok4uw	3936	34	before	before	RB
cord-001835-0s7ok4uw	3936	35	and	and	CC
cord-001835-0s7ok4uw	3936	36	after	after	IN
cord-001835-0s7ok4uw	3936	37	panning	panning	NN
cord-001835-0s7ok4uw	3936	38	were	be	VBD
cord-001835-0s7ok4uw	3936	39	assigned	assign	VBN
cord-001835-0s7ok4uw	3936	40	as	as	IN
cord-001835-0s7ok4uw	3936	41	amplification	amplification	NN
cord-001835-0s7ok4uw	3936	42	rate	rate	NN
cord-001835-0s7ok4uw	3936	43	.	.	.
cord-001835-0s7ok4uw	3937	1	Results	result	NNS
cord-001835-0s7ok4uw	3937	2	and	and	CC
cord-001835-0s7ok4uw	3937	3	discussion	discussion	NN
cord-001835-0s7ok4uw	3937	4	:	:	:
cord-001835-0s7ok4uw	3937	5	VH	VH	NNP
cord-001835-0s7ok4uw	3937	6	sequences	sequence	NNS
cord-001835-0s7ok4uw	3937	7	at	at	IN
cord-001835-0s7ok4uw	3937	8	each	each	DT
cord-001835-0s7ok4uw	3937	9	round	round	NN
cord-001835-0s7ok4uw	3937	10	of	of	IN
cord-001835-0s7ok4uw	3937	11	pooled	pool	VBN
cord-001835-0s7ok4uw	3937	12	phages	phage	NNS
cord-001835-0s7ok4uw	3937	13	after	after	IN
cord-001835-0s7ok4uw	3937	14	biopanning	biopanne	VBG
cord-001835-0s7ok4uw	3937	15	against	against	IN
cord-001835-0s7ok4uw	3937	16	cancer	cancer	NN
cord-001835-0s7ok4uw	3937	17	antigen	antigen	NN
cord-001835-0s7ok4uw	3937	18	were	be	VBD
cord-001835-0s7ok4uw	3937	19	analyzed	analyze	VBN
cord-001835-0s7ok4uw	3937	20	on	on	IN
cord-001835-0s7ok4uw	3937	21	NGS	NGS	NNP
cord-001835-0s7ok4uw	3937	22	.	.	.
cord-001835-0s7ok4uw	3938	1	After	after	IN
cord-001835-0s7ok4uw	3938	2	three	three	CD
cord-001835-0s7ok4uw	3938	3	rounds	round	NNS
cord-001835-0s7ok4uw	3938	4	of	of	IN
cord-001835-0s7ok4uw	3938	5	biopanning	biopanning	NN
cord-001835-0s7ok4uw	3938	6	,	,	,
cord-001835-0s7ok4uw	3938	7	three	three	CD
cord-001835-0s7ok4uw	3938	8	clusters	cluster	NNS
cord-001835-0s7ok4uw	3938	9	of	of	IN
cord-001835-0s7ok4uw	3938	10	antibody	antibody	NN
cord-001835-0s7ok4uw	3938	11	sequences	sequence	NNS
cord-001835-0s7ok4uw	3938	12	were	be	VBD
cord-001835-0s7ok4uw	3938	13	specifically	specifically	RB
cord-001835-0s7ok4uw	3938	14	enriched	enrich	VBN
cord-001835-0s7ok4uw	3938	15	suggesting	suggest	VBG
cord-001835-0s7ok4uw	3938	16	these	these	DT
cord-001835-0s7ok4uw	3938	17	are	be	VBP
cord-001835-0s7ok4uw	3938	18	specific	specific	JJ
cord-001835-0s7ok4uw	3938	19	binders	binder	NNS
cord-001835-0s7ok4uw	3938	20	.	.	.
cord-001835-0s7ok4uw	3939	1	To	to	TO
cord-001835-0s7ok4uw	3939	2	check	check	VB
cord-001835-0s7ok4uw	3939	3	this	this	DT
cord-001835-0s7ok4uw	3939	4	,	,	,
cord-001835-0s7ok4uw	3939	5	scFv	scfv	JJ
cord-001835-0s7ok4uw	3939	6	gene	gene	NN
cord-001835-0s7ok4uw	3939	7	were	be	VBD
cord-001835-0s7ok4uw	3939	8	regenerated	regenerate	VBN
cord-001835-0s7ok4uw	3939	9	by	by	IN
cord-001835-0s7ok4uw	3939	10	PCR	PCR	NNP
cord-001835-0s7ok4uw	3939	11	using	use	VBG
cord-001835-0s7ok4uw	3939	12	H	H	NNP
cord-001835-0s7ok4uw	3939	13	-	-	HYPH
cord-001835-0s7ok4uw	3939	14	CDR3	CDR3	NNP
cord-001835-0s7ok4uw	3939	15	specific	specific	JJ
cord-001835-0s7ok4uw	3939	16	primers	primer	NNS
cord-001835-0s7ok4uw	3939	17	and	and	CC
cord-001835-0s7ok4uw	3939	18	scFv	scFv	NNS
cord-001835-0s7ok4uw	3939	19	-	-	HYPH
cord-001835-0s7ok4uw	3939	20	displaying	display	VBG
cord-001835-0s7ok4uw	3939	21	phages	phage	NNS
cord-001835-0s7ok4uw	3939	22	reconstructed	reconstruct	VBN
cord-001835-0s7ok4uw	3939	23	were	be	VBD
cord-001835-0s7ok4uw	3939	24	subjected	subject	VBN
cord-001835-0s7ok4uw	3939	25	to	to	IN
cord-001835-0s7ok4uw	3939	26	binding	bind	VBG
cord-001835-0s7ok4uw	3939	27	analysis	analysis	NN
cord-001835-0s7ok4uw	3939	28	.	.	.
cord-001835-0s7ok4uw	3940	1	All	all	DT
cord-001835-0s7ok4uw	3940	2	three	three	CD
cord-001835-0s7ok4uw	3940	3	phages	phage	NNS
cord-001835-0s7ok4uw	3940	4	showed	show	VBD
cord-001835-0s7ok4uw	3940	5	a	a	DT
cord-001835-0s7ok4uw	3940	6	clear	clear	JJ
cord-001835-0s7ok4uw	3940	7	specific	specific	JJ
cord-001835-0s7ok4uw	3940	8	binding	binding	NN
cord-001835-0s7ok4uw	3940	9	to	to	IN
cord-001835-0s7ok4uw	3940	10	cancer	cancer	NN
cord-001835-0s7ok4uw	3940	11	antigen	antigen	NN
cord-001835-0s7ok4uw	3940	12	in	in	IN
cord-001835-0s7ok4uw	3940	13	ELISA	ELISA	NNP
cord-001835-0s7ok4uw	3940	14	.	.	.
cord-001835-0s7ok4uw	3941	1	Subsequently	subsequently	RB
cord-001835-0s7ok4uw	3941	2	,	,	,
cord-001835-0s7ok4uw	3941	3	to	to	TO
cord-001835-0s7ok4uw	3941	4	test	test	VB
cord-001835-0s7ok4uw	3941	5	the	the	DT
cord-001835-0s7ok4uw	3941	6	usefulness	usefulness	NN
cord-001835-0s7ok4uw	3941	7	of	of	IN
cord-001835-0s7ok4uw	3941	8	this	this	DT
cord-001835-0s7ok4uw	3941	9	method	method	NN
cord-001835-0s7ok4uw	3941	10	,	,	,
cord-001835-0s7ok4uw	3941	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	3941	12	applied	apply	VBD
cord-001835-0s7ok4uw	3941	13	it	-PRON-	PRP
cord-001835-0s7ok4uw	3941	14	to	to	TO
cord-001835-0s7ok4uw	3941	15	identify	identify	VB
cord-001835-0s7ok4uw	3941	16	allergen	allergen	NN
cord-001835-0s7ok4uw	3941	17	-	-	HYPH
cord-001835-0s7ok4uw	3941	18	specific	specific	JJ
cord-001835-0s7ok4uw	3941	19	scFv	scfv	NN
cord-001835-0s7ok4uw	3941	20	from	from	IN
cord-001835-0s7ok4uw	3941	21	allergy	allergy	NN
cord-001835-0s7ok4uw	3941	22	patient	patient	NN
cord-001835-0s7ok4uw	3941	23	-	-	HYPH
cord-001835-0s7ok4uw	3941	24	derived	derive	VBN
cord-001835-0s7ok4uw	3941	25	antibody	antibody	NN
cord-001835-0s7ok4uw	3941	26	phage	phage	NN
cord-001835-0s7ok4uw	3941	27	library	library	NN
cord-001835-0s7ok4uw	3941	28	.	.	.
cord-001835-0s7ok4uw	3942	1	The	the	DT
cord-001835-0s7ok4uw	3942	2	phylogenetic	phylogenetic	JJ
cord-001835-0s7ok4uw	3942	3	tree	tree	NN
cord-001835-0s7ok4uw	3942	4	analysis	analysis	NN
cord-001835-0s7ok4uw	3942	5	of	of	IN
cord-001835-0s7ok4uw	3942	6	VH	VH	NNP
cord-001835-0s7ok4uw	3942	7	sequences	sequence	NNS
cord-001835-0s7ok4uw	3942	8	which	which	WDT
cord-001835-0s7ok4uw	3942	9	showed	show	VBD
cord-001835-0s7ok4uw	3942	10	the	the	DT
cord-001835-0s7ok4uw	3942	11	amplification	amplification	NN
cord-001835-0s7ok4uw	3942	12	rate	rate	NN
cord-001835-0s7ok4uw	3942	13	higher	high	JJR
cord-001835-0s7ok4uw	3942	14	than	than	IN
cord-001835-0s7ok4uw	3942	15	2.5	2.5	CD
cord-001835-0s7ok4uw	3942	16	by	by	IN
cord-001835-0s7ok4uw	3942	17	a	a	DT
cord-001835-0s7ok4uw	3942	18	single	single	JJ
cord-001835-0s7ok4uw	3942	19	round	round	NN
cord-001835-0s7ok4uw	3942	20	of	of	IN
cord-001835-0s7ok4uw	3942	21	biopanning	biopanning	NN
cord-001835-0s7ok4uw	3942	22	elucidated	elucidate	VBD
cord-001835-0s7ok4uw	3942	23	total	total	JJ
cord-001835-0s7ok4uw	3942	24	eleven	eleven	CD
cord-001835-0s7ok4uw	3942	25	clusters	cluster	NNS
cord-001835-0s7ok4uw	3942	26	of	of	IN
cord-001835-0s7ok4uw	3942	27	VH	VH	NNP
cord-001835-0s7ok4uw	3942	28	sequences	sequence	NNS
cord-001835-0s7ok4uw	3942	29	.	.	.
cord-001835-0s7ok4uw	3943	1	The	the	DT
cord-001835-0s7ok4uw	3943	2	VH	VH	NNP
cord-001835-0s7ok4uw	3943	3	sequences	sequence	NNS
cord-001835-0s7ok4uw	3943	4	in	in	IN
cord-001835-0s7ok4uw	3943	5	the	the	DT
cord-001835-0s7ok4uw	3943	6	two	two	CD
cord-001835-0s7ok4uw	3943	7	clusters	cluster	NNS
cord-001835-0s7ok4uw	3943	8	with	with	IN
cord-001835-0s7ok4uw	3943	9	the	the	DT
cord-001835-0s7ok4uw	3943	10	highest	high	JJS
cord-001835-0s7ok4uw	3943	11	amplification	amplification	NN
cord-001835-0s7ok4uw	3943	12	factor	factor	NN
cord-001835-0s7ok4uw	3943	13	were	be	VBD
cord-001835-0s7ok4uw	3943	14	selected	select	VBN
cord-001835-0s7ok4uw	3943	15	and	and	CC
cord-001835-0s7ok4uw	3943	16	the	the	DT
cord-001835-0s7ok4uw	3943	17	regenerated	regenerate	VBN
cord-001835-0s7ok4uw	3943	18	scFv	scfv	NN
cord-001835-0s7ok4uw	3943	19	-	-	HYPH
cord-001835-0s7ok4uw	3943	20	displayed	display	VBN
cord-001835-0s7ok4uw	3943	21	phages	phage	NNS
cord-001835-0s7ok4uw	3943	22	were	be	VBD
cord-001835-0s7ok4uw	3943	23	tested	test	VBN
cord-001835-0s7ok4uw	3943	24	for	for	IN
cord-001835-0s7ok4uw	3943	25	binding	bind	VBG
cord-001835-0s7ok4uw	3943	26	analysis	analysis	NN
cord-001835-0s7ok4uw	3943	27	.	.	.
cord-001835-0s7ok4uw	3944	1	The	the	DT
cord-001835-0s7ok4uw	3944	2	prepared	prepared	JJ
cord-001835-0s7ok4uw	3944	3	scFvdisplayed	scFvdisplayed	NNP
cord-001835-0s7ok4uw	3944	4	phages	phage	NNS
cord-001835-0s7ok4uw	3944	5	and	and	CC
cord-001835-0s7ok4uw	3944	6	also	also	RB
cord-001835-0s7ok4uw	3944	7	scFv	scfv	JJ
cord-001835-0s7ok4uw	3944	8	proteins	protein	NNS
cord-001835-0s7ok4uw	3944	9	showed	show	VBD
cord-001835-0s7ok4uw	3944	10	a	a	DT
cord-001835-0s7ok4uw	3944	11	clear	clear	JJ
cord-001835-0s7ok4uw	3944	12	binding	binding	JJ
cord-001835-0s7ok4uw	3944	13	ability	ability	NN
cord-001835-0s7ok4uw	3944	14	to	to	IN
cord-001835-0s7ok4uw	3944	15	allergen	allergen	NN
cord-001835-0s7ok4uw	3944	16	.	.	.
cord-001835-0s7ok4uw	3945	1	Thus	thus	RB
cord-001835-0s7ok4uw	3945	2	,	,	,
cord-001835-0s7ok4uw	3945	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	3945	4	is	be	VBZ
cord-001835-0s7ok4uw	3945	5	suggested	suggest	VBN
cord-001835-0s7ok4uw	3945	6	that	that	IN
cord-001835-0s7ok4uw	3945	7	the	the	DT
cord-001835-0s7ok4uw	3945	8	analytical	analytical	JJ
cord-001835-0s7ok4uw	3945	9	method	method	NN
cord-001835-0s7ok4uw	3945	10	of	of	IN
cord-001835-0s7ok4uw	3945	11	VH	VH	NNP
cord-001835-0s7ok4uw	3945	12	sequences	sequence	NNS
cord-001835-0s7ok4uw	3945	13	on	on	IN
cord-001835-0s7ok4uw	3945	14	NGS	NGS	NNP
cord-001835-0s7ok4uw	3945	15	before	before	RB
cord-001835-0s7ok4uw	3945	16	and	and	CC
cord-001835-0s7ok4uw	3945	17	after	after	IN
cord-001835-0s7ok4uw	3945	18	biopanning	biopanning	NN
cord-001835-0s7ok4uw	3945	19	is	be	VBZ
cord-001835-0s7ok4uw	3945	20	very	very	RB
cord-001835-0s7ok4uw	3945	21	useful	useful	JJ
cord-001835-0s7ok4uw	3945	22	to	to	TO
cord-001835-0s7ok4uw	3945	23	isolate	isolate	VB
cord-001835-0s7ok4uw	3945	24	a	a	DT
cord-001835-0s7ok4uw	3945	25	variety	variety	NN
cord-001835-0s7ok4uw	3945	26	of	of	IN
cord-001835-0s7ok4uw	3945	27	disease	disease	NN
cord-001835-0s7ok4uw	3945	28	related	relate	VBN
cord-001835-0s7ok4uw	3945	29	antigen	antigen	NN
cord-001835-0s7ok4uw	3945	30	-	-	HYPH
cord-001835-0s7ok4uw	3945	31	specific	specific	JJ
cord-001835-0s7ok4uw	3945	32	novel	novel	JJ
cord-001835-0s7ok4uw	3945	33	antibodies	antibody	NNS
cord-001835-0s7ok4uw	3945	34	quickly	quickly	RB
cord-001835-0s7ok4uw	3945	35	with	with	IN
cord-001835-0s7ok4uw	3945	36	high	high	JJ
cord-001835-0s7ok4uw	3945	37	degree	degree	NN
cord-001835-0s7ok4uw	3945	38	of	of	IN
cord-001835-0s7ok4uw	3945	39	certainty	certainty	NN
cord-001835-0s7ok4uw	3945	40	.	.	.
cord-001835-0s7ok4uw	3946	1	Biochemical	biochemical	JJ
cord-001835-0s7ok4uw	3946	2	analysis	analysis	NN
cord-001835-0s7ok4uw	3946	3	of	of	IN
cord-001835-0s7ok4uw	3946	4	the	the	DT
cord-001835-0s7ok4uw	3946	5	recognition	recognition	NN
cord-001835-0s7ok4uw	3946	6	helix	helix	NN
cord-001835-0s7ok4uw	3946	7	of	of	IN
cord-001835-0s7ok4uw	3946	8	Z	Z	NNP
cord-001835-0s7ok4uw	3946	9	-	-	HYPH
cord-001835-0s7ok4uw	3946	10	DNA	dna	NN
cord-001835-0s7ok4uw	3946	11	binding	binding	NN
cord-001835-0s7ok4uw	3946	12	proteins	protein	NNS
cord-001835-0s7ok4uw	3946	13	:	:	:
cord-001835-0s7ok4uw	3946	14	Roles	role	NNS
cord-001835-0s7ok4uw	3946	15	in	in	IN
cord-001835-0s7ok4uw	3946	16	conformational	conformational	JJ
cord-001835-0s7ok4uw	3946	17	specificity	specificity	NN
cord-001835-0s7ok4uw	3946	18	Yang	Yang	NNP
cord-001835-0s7ok4uw	3946	19	-	-	HYPH
cord-001835-0s7ok4uw	3946	20	Gyun	Gyun	NNP
cord-001835-0s7ok4uw	3946	21	Kim	Kim	NNP
cord-001835-0s7ok4uw	3946	22	1	1	CD
cord-001835-0s7ok4uw	3946	23	,	,	,
cord-001835-0s7ok4uw	3946	24	Xu	Xu	NNP
cord-001835-0s7ok4uw	3946	25	Zheng	Zheng	NNP
cord-001835-0s7ok4uw	3946	26	1	1	CD
cord-001835-0s7ok4uw	3946	27	,	,	,
cord-001835-0s7ok4uw	3946	28	So	so	RB
cord-001835-0s7ok4uw	3946	29	-	-	HYPH
cord-001835-0s7ok4uw	3946	30	Young	Young	NNP
cord-001835-0s7ok4uw	3946	31	Park	Park	NNP
cord-001835-0s7ok4uw	3946	32	1	1	CD
cord-001835-0s7ok4uw	3946	33	1	1	CD
cord-001835-0s7ok4uw	3946	34	Conversion	conversion	NN
cord-001835-0s7ok4uw	3946	35	of	of	IN
cord-001835-0s7ok4uw	3946	36	right	right	RB
cord-001835-0s7ok4uw	3946	37	-	-	HYPH
cord-001835-0s7ok4uw	3946	38	handed	handed	JJ
cord-001835-0s7ok4uw	3946	39	B	b	NN
cord-001835-0s7ok4uw	3946	40	-	-	HYPH
cord-001835-0s7ok4uw	3946	41	DNA	dna	NN
cord-001835-0s7ok4uw	3946	42	into	into	IN
cord-001835-0s7ok4uw	3946	43	left	left	JJ
cord-001835-0s7ok4uw	3946	44	-	-	HYPH
cord-001835-0s7ok4uw	3946	45	handed	handed	JJ
cord-001835-0s7ok4uw	3946	46	Z	z	NN
cord-001835-0s7ok4uw	3946	47	-	-	HYPH
cord-001835-0s7ok4uw	3946	48	DNA	DNA	NNP
cord-001835-0s7ok4uw	3946	49	is	be	VBZ
cord-001835-0s7ok4uw	3946	50	one	one	CD
cord-001835-0s7ok4uw	3946	51	of	of	IN
cord-001835-0s7ok4uw	3946	52	the	the	DT
cord-001835-0s7ok4uw	3946	53	dramatic	dramatic	JJ
cord-001835-0s7ok4uw	3946	54	structural	structural	JJ
cord-001835-0s7ok4uw	3946	55	transitions	transition	NNS
cord-001835-0s7ok4uw	3946	56	in	in	IN
cord-001835-0s7ok4uw	3946	57	biological	biological	JJ
cord-001835-0s7ok4uw	3946	58	processes	process	NNS
cord-001835-0s7ok4uw	3946	59	including	include	VBG
cord-001835-0s7ok4uw	3946	60	gene	gene	NN
cord-001835-0s7ok4uw	3946	61	regulation	regulation	NN
cord-001835-0s7ok4uw	3946	62	and	and	CC
cord-001835-0s7ok4uw	3946	63	chromatin	chromatin	NN
cord-001835-0s7ok4uw	3946	64	remodeling	remodeling	NN
cord-001835-0s7ok4uw	3946	65	.	.	.
cord-001835-0s7ok4uw	3947	1	Z	z	NN
cord-001835-0s7ok4uw	3947	2	-	-	HYPH
cord-001835-0s7ok4uw	3947	3	DNA	dna	NN
cord-001835-0s7ok4uw	3947	4	binding	binding	NN
cord-001835-0s7ok4uw	3947	5	motif	motif	NN
cord-001835-0s7ok4uw	3947	6	,	,	,
cord-001835-0s7ok4uw	3947	7	Zalpha	Zalpha	NNP
cord-001835-0s7ok4uw	3947	8	(	(	-LRB-
cord-001835-0s7ok4uw	3947	9	Za	Za	NNP
cord-001835-0s7ok4uw	3947	10	)	)	-RRB-
cord-001835-0s7ok4uw	3947	11	,	,	,
cord-001835-0s7ok4uw	3947	12	was	be	VBD
cord-001835-0s7ok4uw	3947	13	first	first	RB
cord-001835-0s7ok4uw	3947	14	discovered	discover	VBN
cord-001835-0s7ok4uw	3947	15	from	from	IN
cord-001835-0s7ok4uw	3947	16	human	human	JJ
cord-001835-0s7ok4uw	3947	17	ADAR1	adar1	NN
cord-001835-0s7ok4uw	3947	18	.	.	.
cord-001835-0s7ok4uw	3948	1	Subsequently	subsequently	RB
cord-001835-0s7ok4uw	3948	2	,	,	,
cord-001835-0s7ok4uw	3948	3	with	with	IN
cord-001835-0s7ok4uw	3948	4	sequence	sequence	NN
cord-001835-0s7ok4uw	3948	5	and	and	CC
cord-001835-0s7ok4uw	3948	6	structure	structure	NN
cord-001835-0s7ok4uw	3948	7	similarity	similarity	NN
cord-001835-0s7ok4uw	3948	8	to	to	IN
cord-001835-0s7ok4uw	3948	9	the	the	DT
cord-001835-0s7ok4uw	3948	10	hZaADAR1	hZaADAR1	NNP
cord-001835-0s7ok4uw	3948	11	,	,	,
cord-001835-0s7ok4uw	3948	12	families	family	NNS
cord-001835-0s7ok4uw	3948	13	of	of	IN
cord-001835-0s7ok4uw	3948	14	proteins	protein	NNS
cord-001835-0s7ok4uw	3948	15	including	include	VBG
cord-001835-0s7ok4uw	3948	16	viral	viral	JJ
cord-001835-0s7ok4uw	3948	17	E3L	e3l	NN
cord-001835-0s7ok4uw	3948	18	,	,	,
cord-001835-0s7ok4uw	3948	19	interferon	interferon	NN
cord-001835-0s7ok4uw	3948	20	-	-	HYPH
cord-001835-0s7ok4uw	3948	21	induced	induce	VBN
cord-001835-0s7ok4uw	3948	22	protein	protein	NN
cord-001835-0s7ok4uw	3948	23	DAI	DAI	NNP
cord-001835-0s7ok4uw	3948	24	(	(	-LRB-
cord-001835-0s7ok4uw	3948	25	ZBP1	ZBP1	NNP
cord-001835-0s7ok4uw	3948	26	)	)	-RRB-
cord-001835-0s7ok4uw	3948	27	and	and	CC
cord-001835-0s7ok4uw	3948	28	PKZ	PKZ	NNP
cord-001835-0s7ok4uw	3948	29	has	have	VBZ
cord-001835-0s7ok4uw	3948	30	been	be	VBN
cord-001835-0s7ok4uw	3948	31	identified	identify	VBN
cord-001835-0s7ok4uw	3948	32	to	to	TO
cord-001835-0s7ok4uw	3948	33	have	have	VB
cord-001835-0s7ok4uw	3948	34	Za	Za	NNP
cord-001835-0s7ok4uw	3948	35	domain(s	domain(s	NNP
cord-001835-0s7ok4uw	3948	36	)	)	-RRB-
cord-001835-0s7ok4uw	3948	37	.	.	.
cord-001835-0s7ok4uw	3949	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	3949	2	,	,	,
cord-001835-0s7ok4uw	3949	3	the	the	DT
cord-001835-0s7ok4uw	3949	4	Za	Za	NNP
cord-001835-0s7ok4uw	3949	5	domain	domain	NN
cord-001835-0s7ok4uw	3949	6	of	of	IN
cord-001835-0s7ok4uw	3949	7	the	the	DT
cord-001835-0s7ok4uw	3949	8	E3L	e3l	NN
cord-001835-0s7ok4uw	3949	9	protein	protein	NN
cord-001835-0s7ok4uw	3949	10	from	from	IN
cord-001835-0s7ok4uw	3949	11	vaccinia	vaccinia	NN
cord-001835-0s7ok4uw	3949	12	virus	virus	NN
cord-001835-0s7ok4uw	3949	13	(	(	-LRB-
cord-001835-0s7ok4uw	3949	14	vvZaE3L	vvZaE3L	NNP
cord-001835-0s7ok4uw	3949	15	)	)	-RRB-
cord-001835-0s7ok4uw	3949	16	was	be	VBD
cord-001835-0s7ok4uw	3949	17	confirmed	confirm	VBN
cord-001835-0s7ok4uw	3949	18	to	to	TO
cord-001835-0s7ok4uw	3949	19	have	have	VB
cord-001835-0s7ok4uw	3949	20	the	the	DT
cord-001835-0s7ok4uw	3949	21	ability	ability	NN
cord-001835-0s7ok4uw	3949	22	of	of	IN
cord-001835-0s7ok4uw	3949	23	Z	z	NN
cord-001835-0s7ok4uw	3949	24	-	-	HYPH
cord-001835-0s7ok4uw	3949	25	DNA	dna	NN
cord-001835-0s7ok4uw	3949	26	-	-	HYPH
cord-001835-0s7ok4uw	3949	27	binding	binding	NN
cord-001835-0s7ok4uw	3949	28	,	,	,
cord-001835-0s7ok4uw	3949	29	but	but	CC
cord-001835-0s7ok4uw	3949	30	it	-PRON-	PRP
cord-001835-0s7ok4uw	3949	31	does	do	VBZ
cord-001835-0s7ok4uw	3949	32	not	not	RB
cord-001835-0s7ok4uw	3949	33	have	have	VB
cord-001835-0s7ok4uw	3949	34	the	the	DT
cord-001835-0s7ok4uw	3949	35	B	b	NN
cord-001835-0s7ok4uw	3949	36	-	-	HYPH
cord-001835-0s7ok4uw	3949	37	to	to	IN
cord-001835-0s7ok4uw	3949	38	-	-	HYPH
cord-001835-0s7ok4uw	3949	39	Z	z	NN
cord-001835-0s7ok4uw	3949	40	conversion	conversion	NN
cord-001835-0s7ok4uw	3949	41	activity	activity	NN
cord-001835-0s7ok4uw	3949	42	.	.	.
cord-001835-0s7ok4uw	3950	1	Here	here	RB
cord-001835-0s7ok4uw	3950	2	,	,	,
cord-001835-0s7ok4uw	3950	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3950	4	showed	show	VBD
cord-001835-0s7ok4uw	3950	5	that	that	IN
cord-001835-0s7ok4uw	3950	6	the	the	DT
cord-001835-0s7ok4uw	3950	7	replacement	replacement	NN
cord-001835-0s7ok4uw	3950	8	of	of	IN
cord-001835-0s7ok4uw	3950	9	the	the	DT
cord-001835-0s7ok4uw	3950	10	a3-helix	a3-helix	NNS
cord-001835-0s7ok4uw	3950	11	of	of	IN
cord-001835-0s7ok4uw	3950	12	vvZaE3L	vvZaE3L	NNS
cord-001835-0s7ok4uw	3950	13	(	(	-LRB-
cord-001835-0s7ok4uw	3950	14	vvZaE3L	vvZaE3L	NNP
cord-001835-0s7ok4uw	3950	15	-	-	HYPH
cord-001835-0s7ok4uw	3950	16	a3	a3	NNP
cord-001835-0s7ok4uw	3950	17	)	)	-RRB-
cord-001835-0s7ok4uw	3950	18	with	with	IN
cord-001835-0s7ok4uw	3950	19	that	that	DT
cord-001835-0s7ok4uw	3950	20	of	of	IN
cord-001835-0s7ok4uw	3950	21	hZaADAR1	hzaadar1	NN
cord-001835-0s7ok4uw	3950	22	results	result	NNS
cord-001835-0s7ok4uw	3950	23	in	in	IN
cord-001835-0s7ok4uw	3950	24	acquiring	acquire	VBG
cord-001835-0s7ok4uw	3950	25	the	the	DT
cord-001835-0s7ok4uw	3950	26	ability	ability	NN
cord-001835-0s7ok4uw	3950	27	to	to	IN
cord-001835-0s7ok4uw	3950	28	converting	convert	VBG
cord-001835-0s7ok4uw	3950	29	B	b	NN
cord-001835-0s7ok4uw	3950	30	-	-	HYPH
cord-001835-0s7ok4uw	3950	31	DNA	dna	NN
cord-001835-0s7ok4uw	3950	32	to	to	IN
cord-001835-0s7ok4uw	3950	33	Z	z	NN
cord-001835-0s7ok4uw	3950	34	-	-	HYPH
cord-001835-0s7ok4uw	3950	35	DNA	dna	NN
cord-001835-0s7ok4uw	3950	36	.	.	.
cord-001835-0s7ok4uw	3951	1	The	the	DT
cord-001835-0s7ok4uw	3951	2	detailed	detailed	JJ
cord-001835-0s7ok4uw	3951	3	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	3951	4	analysis	analysis	NN
cord-001835-0s7ok4uw	3951	5	of	of	IN
cord-001835-0s7ok4uw	3951	6	the	the	DT
cord-001835-0s7ok4uw	3951	7	a3-helix	a3-helix	NNP
cord-001835-0s7ok4uw	3951	8	mutants	mutant	NNS
cord-001835-0s7ok4uw	3951	9	of	of	IN
cord-001835-0s7ok4uw	3951	10	vvZaE3L	vvZaE3L	NNS
cord-001835-0s7ok4uw	3951	11	further	further	RB
cord-001835-0s7ok4uw	3951	12	suggested	suggest	VBD
cord-001835-0s7ok4uw	3951	13	that	that	IN
cord-001835-0s7ok4uw	3951	14	the	the	DT
cord-001835-0s7ok4uw	3951	15	contribution	contribution	NN
cord-001835-0s7ok4uw	3951	16	of	of	IN
cord-001835-0s7ok4uw	3951	17	positively	positively	RB
cord-001835-0s7ok4uw	3951	18	charged	charge	VBN
cord-001835-0s7ok4uw	3951	19	residues	residue	NNS
cord-001835-0s7ok4uw	3951	20	in	in	IN
cord-001835-0s7ok4uw	3951	21	the	the	DT
cord-001835-0s7ok4uw	3951	22	C	c	NN
cord-001835-0s7ok4uw	3951	23	-	-	HYPH
cord-001835-0s7ok4uw	3951	24	terminal	terminal	NN
cord-001835-0s7ok4uw	3951	25	part	part	NN
cord-001835-0s7ok4uw	3951	26	of	of	IN
cord-001835-0s7ok4uw	3951	27	the	the	DT
cord-001835-0s7ok4uw	3951	28	a3-helix	a3-helix	NNP
cord-001835-0s7ok4uw	3951	29	is	be	VBZ
cord-001835-0s7ok4uw	3951	30	crucial	crucial	JJ
cord-001835-0s7ok4uw	3951	31	during	during	IN
cord-001835-0s7ok4uw	3951	32	the	the	DT
cord-001835-0s7ok4uw	3951	33	B	b	NN
cord-001835-0s7ok4uw	3951	34	-	-	HYPH
cord-001835-0s7ok4uw	3951	35	to	to	IN
cord-001835-0s7ok4uw	3951	36	-	-	HYPH
cord-001835-0s7ok4uw	3951	37	Z	z	NN
cord-001835-0s7ok4uw	3951	38	transition	transition	NN
cord-001835-0s7ok4uw	3951	39	.	.	.
cord-001835-0s7ok4uw	3952	1	In	in	IN
cord-001835-0s7ok4uw	3952	2	addition	addition	NN
cord-001835-0s7ok4uw	3952	3	,	,	,
cord-001835-0s7ok4uw	3952	4	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3952	5	residues	residue	NNS
cord-001835-0s7ok4uw	3952	6	of	of	IN
cord-001835-0s7ok4uw	3952	7	the	the	DT
cord-001835-0s7ok4uw	3952	8	N	n	CD
cord-001835-0s7ok4uw	3952	9	-	-	HYPH
cord-001835-0s7ok4uw	3952	10	terminal	terminal	JJ
cord-001835-0s7ok4uw	3952	11	part	part	NN
cord-001835-0s7ok4uw	3952	12	of	of	IN
cord-001835-0s7ok4uw	3952	13	the	the	DT
cord-001835-0s7ok4uw	3952	14	vvZaE3L	vvZaE3L	NNS
cord-001835-0s7ok4uw	3952	15	-	-	HYPH
cord-001835-0s7ok4uw	3952	16	a3	a3	NNP
cord-001835-0s7ok4uw	3952	17	also	also	RB
cord-001835-0s7ok4uw	3952	18	influence	influence	VBP
cord-001835-0s7ok4uw	3952	19	on	on	IN
cord-001835-0s7ok4uw	3952	20	the	the	DT
cord-001835-0s7ok4uw	3952	21	B	b	NN
cord-001835-0s7ok4uw	3952	22	-	-	HYPH
cord-001835-0s7ok4uw	3952	23	to	to	IN
cord-001835-0s7ok4uw	3952	24	-	-	HYPH
cord-001835-0s7ok4uw	3952	25	Z	z	NN
cord-001835-0s7ok4uw	3952	26	conversion	conversion	NN
cord-001835-0s7ok4uw	3952	27	activity	activity	NN
cord-001835-0s7ok4uw	3952	28	,	,	,
cord-001835-0s7ok4uw	3952	29	possibly	possibly	RB
cord-001835-0s7ok4uw	3952	30	through	through	IN
cord-001835-0s7ok4uw	3952	31	forming	form	VBG
cord-001835-0s7ok4uw	3952	32	a	a	DT
cord-001835-0s7ok4uw	3952	33	tightly	tightly	RB
cord-001835-0s7ok4uw	3952	34	-	-	HYPH
cord-001835-0s7ok4uw	3952	35	packed	pack	VBN
cord-001835-0s7ok4uw	3952	36	structure	structure	NN
cord-001835-0s7ok4uw	3952	37	.	.	.
cord-001835-0s7ok4uw	3953	1	In	in	IN
cord-001835-0s7ok4uw	3953	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	3953	3	,	,	,
cord-001835-0s7ok4uw	3953	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3953	5	results	result	NNS
cord-001835-0s7ok4uw	3953	6	revealed	reveal	VBD
cord-001835-0s7ok4uw	3953	7	the	the	DT
cord-001835-0s7ok4uw	3953	8	previously	previously	RB
cord-001835-0s7ok4uw	3953	9	-	-	HYPH
cord-001835-0s7ok4uw	3953	10	unknown	unknown	JJ
cord-001835-0s7ok4uw	3953	11	contribution	contribution	NN
cord-001835-0s7ok4uw	3953	12	of	of	IN
cord-001835-0s7ok4uw	3953	13	amino	amino	JJ
cord-001835-0s7ok4uw	3953	14	acid	acid	NN
cord-001835-0s7ok4uw	3953	15	residues	residue	NNS
cord-001835-0s7ok4uw	3953	16	existed	exist	VBD
cord-001835-0s7ok4uw	3953	17	in	in	IN
cord-001835-0s7ok4uw	3953	18	the	the	DT
cord-001835-0s7ok4uw	3953	19	a3-helix	a3-helix	NNS
cord-001835-0s7ok4uw	3953	20	of	of	IN
cord-001835-0s7ok4uw	3953	21	the	the	DT
cord-001835-0s7ok4uw	3953	22	Za	Za	NNP
cord-001835-0s7ok4uw	3953	23	domains	domain	NNS
cord-001835-0s7ok4uw	3953	24	to	to	IN
cord-001835-0s7ok4uw	3953	25	the	the	DT
cord-001835-0s7ok4uw	3953	26	B	b	NN
cord-001835-0s7ok4uw	3953	27	-	-	HYPH
cord-001835-0s7ok4uw	3953	28	to	to	IN
cord-001835-0s7ok4uw	3953	29	-	-	HYPH
cord-001835-0s7ok4uw	3953	30	Z	z	NN
cord-001835-0s7ok4uw	3953	31	conversion	conversion	NN
cord-001835-0s7ok4uw	3953	32	.	.	.
cord-001835-0s7ok4uw	3954	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	3954	2	,	,	,
cord-001835-0s7ok4uw	3954	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	3954	4	strongly	strongly	RB
cord-001835-0s7ok4uw	3954	5	implies	imply	VBZ
cord-001835-0s7ok4uw	3954	6	that	that	IN
cord-001835-0s7ok4uw	3954	7	such	such	JJ
cord-001835-0s7ok4uw	3954	8	residues	residue	NNS
cord-001835-0s7ok4uw	3954	9	may	may	MD
cord-001835-0s7ok4uw	3954	10	play	play	VB
cord-001835-0s7ok4uw	3954	11	important	important	JJ
cord-001835-0s7ok4uw	3954	12	roles	role	NNS
cord-001835-0s7ok4uw	3954	13	in	in	IN
cord-001835-0s7ok4uw	3954	14	initiating	initiate	VBG
cord-001835-0s7ok4uw	3954	15	conformational	conformational	JJ
cord-001835-0s7ok4uw	3954	16	changes	change	NNS
cord-001835-0s7ok4uw	3954	17	of	of	IN
cord-001835-0s7ok4uw	3954	18	DNA	dna	NN
cord-001835-0s7ok4uw	3954	19	structure	structure	NN
cord-001835-0s7ok4uw	3954	20	during	during	IN
cord-001835-0s7ok4uw	3954	21	the	the	DT
cord-001835-0s7ok4uw	3954	22	B	b	NN
cord-001835-0s7ok4uw	3954	23	-	-	HYPH
cord-001835-0s7ok4uw	3954	24	to	to	IN
cord-001835-0s7ok4uw	3954	25	-	-	HYPH
cord-001835-0s7ok4uw	3954	26	Z	z	NN
cord-001835-0s7ok4uw	3954	27	conversion	conversion	NN
cord-001835-0s7ok4uw	3954	28	event	event	NN
cord-001835-0s7ok4uw	3954	29	.	.	.
cord-001835-0s7ok4uw	3954	30	 	 	_SP
cord-001835-0s7ok4uw	3955	1	The	the	DT
cord-001835-0s7ok4uw	3955	2	ability	ability	NN
cord-001835-0s7ok4uw	3955	3	of	of	IN
cord-001835-0s7ok4uw	3955	4	switching	switch	VBG
cord-001835-0s7ok4uw	3955	5	the	the	DT
cord-001835-0s7ok4uw	3955	6	activity	activity	NN
cord-001835-0s7ok4uw	3955	7	of	of	IN
cord-001835-0s7ok4uw	3955	8	proteins	protein	NNS
cord-001835-0s7ok4uw	3955	9	at	at	IN
cord-001835-0s7ok4uw	3955	10	will	will	NN
cord-001835-0s7ok4uw	3955	11	is	be	VBZ
cord-001835-0s7ok4uw	3955	12	of	of	IN
cord-001835-0s7ok4uw	3955	13	great	great	JJ
cord-001835-0s7ok4uw	3955	14	interest	interest	NN
cord-001835-0s7ok4uw	3955	15	from	from	IN
cord-001835-0s7ok4uw	3955	16	an	an	DT
cord-001835-0s7ok4uw	3955	17	application	application	NN
cord-001835-0s7ok4uw	3955	18	point	point	NN
cord-001835-0s7ok4uw	3955	19	of	of	IN
cord-001835-0s7ok4uw	3955	20	view	view	NN
cord-001835-0s7ok4uw	3955	21	.	.	.
cord-001835-0s7ok4uw	3956	1	One	one	CD
cord-001835-0s7ok4uw	3956	2	promising	promising	JJ
cord-001835-0s7ok4uw	3956	3	approach	approach	NN
cord-001835-0s7ok4uw	3956	4	utilizes	utilize	VBZ
cord-001835-0s7ok4uw	3956	5	a	a	DT
cord-001835-0s7ok4uw	3956	6	protein	protein	NN
cord-001835-0s7ok4uw	3956	7	modification	modification	NN
cord-001835-0s7ok4uw	3956	8	with	with	IN
cord-001835-0s7ok4uw	3956	9	an	an	DT
cord-001835-0s7ok4uw	3956	10	organic	organic	JJ
cord-001835-0s7ok4uw	3956	11	photochromic	photochromic	JJ
cord-001835-0s7ok4uw	3956	12	molecule	molecule	NN
cord-001835-0s7ok4uw	3956	13	.	.	.
cord-001835-0s7ok4uw	3957	1	Linking	link	VBG
cord-001835-0s7ok4uw	3957	2	two	two	CD
cord-001835-0s7ok4uw	3957	3	protein	protein	NN
cord-001835-0s7ok4uw	3957	4	side	side	NN
cord-001835-0s7ok4uw	3957	5	chains	chain	NNS
cord-001835-0s7ok4uw	3957	6	with	with	IN
cord-001835-0s7ok4uw	3957	7	the	the	DT
cord-001835-0s7ok4uw	3957	8	photochrome	photochrome	NN
cord-001835-0s7ok4uw	3957	9	that	that	WDT
cord-001835-0s7ok4uw	3957	10	undergoes	undergo	VBZ
cord-001835-0s7ok4uw	3957	11	a	a	DT
cord-001835-0s7ok4uw	3957	12	light	light	NN
cord-001835-0s7ok4uw	3957	13	induced	induce	VBN
cord-001835-0s7ok4uw	3957	14	conformational	conformational	JJ
cord-001835-0s7ok4uw	3957	15	change	change	NN
cord-001835-0s7ok4uw	3957	16	,	,	,
cord-001835-0s7ok4uw	3957	17	protein	protein	NN
cord-001835-0s7ok4uw	3957	18	secondary	secondary	JJ
cord-001835-0s7ok4uw	3957	19	and	and	CC
cord-001835-0s7ok4uw	3957	20	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	3957	21	structure	structure	NN
cord-001835-0s7ok4uw	3957	22	can	can	MD
cord-001835-0s7ok4uw	3957	23	be	be	VB
cord-001835-0s7ok4uw	3957	24	stabilized	stabilize	VBN
cord-001835-0s7ok4uw	3957	25	or	or	CC
cord-001835-0s7ok4uw	3957	26	destabilized	destabilize	VBN
cord-001835-0s7ok4uw	3957	27	and	and	CC
cord-001835-0s7ok4uw	3957	28	thus	thus	RB
cord-001835-0s7ok4uw	3957	29	the	the	DT
cord-001835-0s7ok4uw	3957	30	structure	structure	NN
cord-001835-0s7ok4uw	3957	31	dependent	dependent	JJ
cord-001835-0s7ok4uw	3957	32	activity	activity	NN
cord-001835-0s7ok4uw	3957	33	can	can	MD
cord-001835-0s7ok4uw	3957	34	be	be	VB
cord-001835-0s7ok4uw	3957	35	switched	switch	VBN
cord-001835-0s7ok4uw	3957	36	"	"	``
cord-001835-0s7ok4uw	3957	37	on	on	IN
cord-001835-0s7ok4uw	3957	38	"	"	''
cord-001835-0s7ok4uw	3957	39	and	and	CC
cord-001835-0s7ok4uw	3957	40	"	"	``
cord-001835-0s7ok4uw	3957	41	off	off	RB
cord-001835-0s7ok4uw	3957	42	"	"	''
cord-001835-0s7ok4uw	3957	43	by	by	IN
cord-001835-0s7ok4uw	3957	44	light	light	JJ
cord-001835-0s7ok4uw	3957	45	irradiation	irradiation	NN
cord-001835-0s7ok4uw	3957	46	.	.	.
cord-001835-0s7ok4uw	3958	1	For	for	IN
cord-001835-0s7ok4uw	3958	2	this	this	DT
cord-001835-0s7ok4uw	3958	3	the	the	DT
cord-001835-0s7ok4uw	3958	4	photochrome	photochrome	NN
cord-001835-0s7ok4uw	3958	5	must	must	MD
cord-001835-0s7ok4uw	3958	6	fulfil	fulfil	VB
cord-001835-0s7ok4uw	3958	7	several	several	JJ
cord-001835-0s7ok4uw	3958	8	requirements	requirement	NNS
cord-001835-0s7ok4uw	3958	9	.	.	.
cord-001835-0s7ok4uw	3959	1	Foremost	foremost	RB
cord-001835-0s7ok4uw	3959	2	,	,	,
cord-001835-0s7ok4uw	3959	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	3959	4	must	must	MD
cord-001835-0s7ok4uw	3959	5	possess	possess	VB
cord-001835-0s7ok4uw	3959	6	two	two	CD
cord-001835-0s7ok4uw	3959	7	states	state	NNS
cord-001835-0s7ok4uw	3959	8	of	of	IN
cord-001835-0s7ok4uw	3959	9	comparable	comparable	JJ
cord-001835-0s7ok4uw	3959	10	stability	stability	NN
cord-001835-0s7ok4uw	3959	11	that	that	WDT
cord-001835-0s7ok4uw	3959	12	differ	differ	VBP
cord-001835-0s7ok4uw	3959	13	significantly	significantly	RB
cord-001835-0s7ok4uw	3959	14	in	in	IN
cord-001835-0s7ok4uw	3959	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3959	16	geometry	geometry	NN
cord-001835-0s7ok4uw	3959	17	.	.	.
cord-001835-0s7ok4uw	3960	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3960	2	must	must	MD
cord-001835-0s7ok4uw	3960	3	further	further	RB
cord-001835-0s7ok4uw	3960	4	be	be	VB
cord-001835-0s7ok4uw	3960	5	water	water	NN
cord-001835-0s7ok4uw	3960	6	soluble	soluble	JJ
cord-001835-0s7ok4uw	3960	7	and	and	CC
cord-001835-0s7ok4uw	3960	8	non	non	JJ
cord-001835-0s7ok4uw	3960	9	-	-	JJ
cord-001835-0s7ok4uw	3960	10	toxic	toxic	JJ
cord-001835-0s7ok4uw	3960	11	,	,	,
cord-001835-0s7ok4uw	3960	12	and	and	CC
cord-001835-0s7ok4uw	3960	13	should	should	MD
cord-001835-0s7ok4uw	3960	14	not	not	RB
cord-001835-0s7ok4uw	3960	15	experience	experience	VB
cord-001835-0s7ok4uw	3960	16	fatigue	fatigue	NN
cord-001835-0s7ok4uw	3960	17	phenomena	phenomenon	NNS
cord-001835-0s7ok4uw	3960	18	upon	upon	IN
cord-001835-0s7ok4uw	3960	19	multiple	multiple	JJ
cord-001835-0s7ok4uw	3960	20	irradiations	irradiation	NNS
cord-001835-0s7ok4uw	3960	21	.	.	.
cord-001835-0s7ok4uw	3961	1	There	there	EX
cord-001835-0s7ok4uw	3961	2	are	be	VBP
cord-001835-0s7ok4uw	3961	3	two	two	CD
cord-001835-0s7ok4uw	3961	4	classes	class	NNS
cord-001835-0s7ok4uw	3961	5	of	of	IN
cord-001835-0s7ok4uw	3961	6	molecules	molecule	NNS
cord-001835-0s7ok4uw	3961	7	that	that	WDT
cord-001835-0s7ok4uw	3961	8	fulfil	fulfil	VBP
cord-001835-0s7ok4uw	3961	9	those	those	DT
cord-001835-0s7ok4uw	3961	10	requirements	requirement	NNS
cord-001835-0s7ok4uw	3961	11	:	:	:
cord-001835-0s7ok4uw	3961	12	azobenzenes	azobenzenes	NNP
cord-001835-0s7ok4uw	3961	13	and	and	CC
cord-001835-0s7ok4uw	3961	14	spiropyrans	spiropyran	NNS
cord-001835-0s7ok4uw	3961	15	.	.	.
cord-001835-0s7ok4uw	3962	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3962	2	are	be	VBP
cord-001835-0s7ok4uw	3962	3	pursuing	pursue	VBG
cord-001835-0s7ok4uw	3962	4	two	two	CD
cord-001835-0s7ok4uw	3962	5	different	different	JJ
cord-001835-0s7ok4uw	3962	6	strategies	strategy	NNS
cord-001835-0s7ok4uw	3962	7	for	for	IN
cord-001835-0s7ok4uw	3962	8	the	the	DT
cord-001835-0s7ok4uw	3962	9	design	design	NN
cord-001835-0s7ok4uw	3962	10	of	of	IN
cord-001835-0s7ok4uw	3962	11	photoswitchable	photoswitchable	JJ
cord-001835-0s7ok4uw	3962	12	proteins	protein	NNS
cord-001835-0s7ok4uw	3962	13	.	.	.
cord-001835-0s7ok4uw	3963	1	In	in	IN
cord-001835-0s7ok4uw	3963	2	the	the	DT
cord-001835-0s7ok4uw	3963	3	first	first	JJ
cord-001835-0s7ok4uw	3963	4	approach	approach	NN
cord-001835-0s7ok4uw	3963	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3963	6	attach	attach	VBP
cord-001835-0s7ok4uw	3963	7	an	an	DT
cord-001835-0s7ok4uw	3963	8	azobenzene	azobenzene	NN
cord-001835-0s7ok4uw	3963	9	compounds	compound	NNS
cord-001835-0s7ok4uw	3963	10	to	to	TO
cord-001835-0s7ok4uw	3963	11	side	side	VB
cord-001835-0s7ok4uw	3963	12	chains	chain	NNS
cord-001835-0s7ok4uw	3963	13	of	of	IN
cord-001835-0s7ok4uw	3963	14	the	the	DT
cord-001835-0s7ok4uw	3963	15	alpha	alpha	NN
cord-001835-0s7ok4uw	3963	16	-	-	HYPH
cord-001835-0s7ok4uw	3963	17	helical	helical	JJ
cord-001835-0s7ok4uw	3963	18	antifreeze	antifreeze	NN
cord-001835-0s7ok4uw	3963	19	protein	protein	NN
cord-001835-0s7ok4uw	3963	20	Type	type	NN
cord-001835-0s7ok4uw	3963	21	I.	i.	NN
cord-001835-0s7ok4uw	3964	1	The	the	DT
cord-001835-0s7ok4uw	3964	2	end	end	NN
cord-001835-0s7ok4uw	3964	3	to	to	TO
cord-001835-0s7ok4uw	3964	4	end	end	VB
cord-001835-0s7ok4uw	3964	5	distance	distance	NN
cord-001835-0s7ok4uw	3964	6	of	of	IN
cord-001835-0s7ok4uw	3964	7	the	the	DT
cord-001835-0s7ok4uw	3964	8	photochromic	photochromic	JJ
cord-001835-0s7ok4uw	3964	9	molecule	molecule	NN
cord-001835-0s7ok4uw	3964	10	is	be	VBZ
cord-001835-0s7ok4uw	3964	11	sterically	sterically	RB
cord-001835-0s7ok4uw	3964	12	compatible	compatible	JJ
cord-001835-0s7ok4uw	3964	13	with	with	IN
cord-001835-0s7ok4uw	3964	14	the	the	DT
cord-001835-0s7ok4uw	3964	15	folded	fold	VBN
cord-001835-0s7ok4uw	3964	16	helix	helix	NN
cord-001835-0s7ok4uw	3964	17	only	only	RB
cord-001835-0s7ok4uw	3964	18	in	in	IN
cord-001835-0s7ok4uw	3964	19	one	one	CD
cord-001835-0s7ok4uw	3964	20	form	form	NN
cord-001835-0s7ok4uw	3964	21	,	,	,
cord-001835-0s7ok4uw	3964	22	photoisomerization	photoisomerization	NN
cord-001835-0s7ok4uw	3964	23	therefore	therefore	RB
cord-001835-0s7ok4uw	3964	24	switches	switch	VBZ
cord-001835-0s7ok4uw	3964	25	the	the	DT
cord-001835-0s7ok4uw	3964	26	folding	fold	VBG
cord-001835-0s7ok4uw	3964	27	state	state	NN
cord-001835-0s7ok4uw	3964	28	between	between	IN
cord-001835-0s7ok4uw	3964	29	an	an	DT
cord-001835-0s7ok4uw	3964	30	active	active	JJ
cord-001835-0s7ok4uw	3964	31	helical	helical	JJ
cord-001835-0s7ok4uw	3964	32	state	state	NN
cord-001835-0s7ok4uw	3964	33	and	and	CC
cord-001835-0s7ok4uw	3964	34	an	an	DT
cord-001835-0s7ok4uw	3964	35	inactive	inactive	JJ
cord-001835-0s7ok4uw	3964	36	unfolded	unfold	VBN
cord-001835-0s7ok4uw	3964	37	form	form	NN
cord-001835-0s7ok4uw	3964	38	.	.	.
cord-001835-0s7ok4uw	3965	1	In	in	IN
cord-001835-0s7ok4uw	3965	2	a	a	DT
cord-001835-0s7ok4uw	3965	3	second	second	NN
cord-001835-0s7ok4uw	3965	4	,	,	,
cord-001835-0s7ok4uw	3965	5	more	more	RBR
cord-001835-0s7ok4uw	3965	6	general	general	JJ
cord-001835-0s7ok4uw	3965	7	approach	approach	NN
cord-001835-0s7ok4uw	3965	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	3965	9	use	use	VBP
cord-001835-0s7ok4uw	3965	10	the	the	DT
cord-001835-0s7ok4uw	3965	11	Trp	Trp	NNP
cord-001835-0s7ok4uw	3965	12	-	-	HYPH
cord-001835-0s7ok4uw	3965	13	Cage	Cage	NNP
cord-001835-0s7ok4uw	3965	14	domain	domain	NN
cord-001835-0s7ok4uw	3965	15	as	as	IN
cord-001835-0s7ok4uw	3965	16	a	a	DT
cord-001835-0s7ok4uw	3965	17	switching	switch	VBG
cord-001835-0s7ok4uw	3965	18	unit	unit	NN
cord-001835-0s7ok4uw	3965	19	.	.	.
cord-001835-0s7ok4uw	3966	1	The	the	DT
cord-001835-0s7ok4uw	3966	2	Trp	Trp	NNP
cord-001835-0s7ok4uw	3966	3	-	-	HYPH
cord-001835-0s7ok4uw	3966	4	Cage	Cage	NNP
cord-001835-0s7ok4uw	3966	5	is	be	VBZ
cord-001835-0s7ok4uw	3966	6	the	the	DT
cord-001835-0s7ok4uw	3966	7	smallest	smallest	RBS
cord-001835-0s7ok4uw	3966	8	known	know	VBN
cord-001835-0s7ok4uw	3966	9	folded	fold	VBN
cord-001835-0s7ok4uw	3966	10	protein	protein	NN
cord-001835-0s7ok4uw	3966	11	(	(	-LRB-
cord-001835-0s7ok4uw	3966	12	20	20	CD
cord-001835-0s7ok4uw	3966	13	amino	amino	JJ
cord-001835-0s7ok4uw	3966	14	acids	acid	NNS
cord-001835-0s7ok4uw	3966	15	)	)	-RRB-
cord-001835-0s7ok4uw	3966	16	.	.	.
cord-001835-0s7ok4uw	3967	1	Its	-PRON-	PRP$
cord-001835-0s7ok4uw	3967	2	folding	folding	NN
cord-001835-0s7ok4uw	3967	3	is	be	VBZ
cord-001835-0s7ok4uw	3967	4	induced	induce	VBN
cord-001835-0s7ok4uw	3967	5	by	by	IN
cord-001835-0s7ok4uw	3967	6	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3967	7	interactions	interaction	NNS
cord-001835-0s7ok4uw	3967	8	of	of	IN
cord-001835-0s7ok4uw	3967	9	a	a	DT
cord-001835-0s7ok4uw	3967	10	tryptophan	tryptophan	NN
cord-001835-0s7ok4uw	3967	11	side	side	NN
cord-001835-0s7ok4uw	3967	12	chain	chain	NN
cord-001835-0s7ok4uw	3967	13	in	in	IN
cord-001835-0s7ok4uw	3967	14	a	a	DT
cord-001835-0s7ok4uw	3967	15	short	short	JJ
cord-001835-0s7ok4uw	3967	16	helical	helical	JJ
cord-001835-0s7ok4uw	3967	17	segment	segment	NN
cord-001835-0s7ok4uw	3967	18	.	.	.
cord-001835-0s7ok4uw	3968	1	After	after	IN
cord-001835-0s7ok4uw	3968	2	modification	modification	NN
cord-001835-0s7ok4uw	3968	3	with	with	IN
cord-001835-0s7ok4uw	3968	4	a	a	DT
cord-001835-0s7ok4uw	3968	5	photochromic	photochromic	JJ
cord-001835-0s7ok4uw	3968	6	molecule	molecule	NN
cord-001835-0s7ok4uw	3968	7	in	in	IN
cord-001835-0s7ok4uw	3968	8	appropriate	appropriate	JJ
cord-001835-0s7ok4uw	3968	9	positions	position	NNS
cord-001835-0s7ok4uw	3968	10	,	,	,
cord-001835-0s7ok4uw	3968	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	3968	12	structure	structure	NN
cord-001835-0s7ok4uw	3968	13	is	be	VBZ
cord-001835-0s7ok4uw	3968	14	rendered	render	VBN
cord-001835-0s7ok4uw	3968	15	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	3968	16	to	to	IN
cord-001835-0s7ok4uw	3968	17	the	the	DT
cord-001835-0s7ok4uw	3968	18	state	state	NN
cord-001835-0s7ok4uw	3968	19	of	of	IN
cord-001835-0s7ok4uw	3968	20	the	the	DT
cord-001835-0s7ok4uw	3968	21	chromophore	chromophore	NN
cord-001835-0s7ok4uw	3968	22	.	.	.
cord-001835-0s7ok4uw	3969	1	By	by	IN
cord-001835-0s7ok4uw	3969	2	creating	create	VBG
cord-001835-0s7ok4uw	3969	3	protein	protein	NN
cord-001835-0s7ok4uw	3969	4	chimera	chimera	NN
cord-001835-0s7ok4uw	3969	5	of	of	IN
cord-001835-0s7ok4uw	3969	6	such	such	PDT
cord-001835-0s7ok4uw	3969	7	a	a	DT
cord-001835-0s7ok4uw	3969	8	Trp	Trp	NNP
cord-001835-0s7ok4uw	3969	9	-	-	HYPH
cord-001835-0s7ok4uw	3969	10	Cage	cage	NN
cord-001835-0s7ok4uw	3969	11	and	and	CC
cord-001835-0s7ok4uw	3969	12	biologically	biologically	RB
cord-001835-0s7ok4uw	3969	13	active	active	JJ
cord-001835-0s7ok4uw	3969	14	peptides	peptide	NNS
cord-001835-0s7ok4uw	3969	15	with	with	IN
cord-001835-0s7ok4uw	3969	16	helical	helical	JJ
cord-001835-0s7ok4uw	3969	17	propensity	propensity	NN
cord-001835-0s7ok4uw	3969	18	,	,	,
cord-001835-0s7ok4uw	3969	19	we	-PRON-	PRP
cord-001835-0s7ok4uw	3969	20	aim	aim	VBP
cord-001835-0s7ok4uw	3969	21	at	at	IN
cord-001835-0s7ok4uw	3969	22	conferring	confer	VBG
cord-001835-0s7ok4uw	3969	23	the	the	DT
cord-001835-0s7ok4uw	3969	24	light	light	JJ
cord-001835-0s7ok4uw	3969	25	-	-	HYPH
cord-001835-0s7ok4uw	3969	26	dependent	dependent	JJ
cord-001835-0s7ok4uw	3969	27	fold	fold	NN
cord-001835-0s7ok4uw	3969	28	of	of	IN
cord-001835-0s7ok4uw	3969	29	the	the	DT
cord-001835-0s7ok4uw	3969	30	cage	cage	NN
cord-001835-0s7ok4uw	3969	31	to	to	IN
cord-001835-0s7ok4uw	3969	32	the	the	DT
cord-001835-0s7ok4uw	3969	33	attached	attach	VBN
cord-001835-0s7ok4uw	3969	34	peptide	peptide	NN
cord-001835-0s7ok4uw	3969	35	moiety	moiety	NN
cord-001835-0s7ok4uw	3969	36	.	.	.
cord-001835-0s7ok4uw	3970	1	Salt	salt	NN
cord-001835-0s7ok4uw	3970	2	-	-	HYPH
cord-001835-0s7ok4uw	3970	3	bridges	bridge	NNS
cord-001835-0s7ok4uw	3970	4	are	be	VBP
cord-001835-0s7ok4uw	3970	5	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	3970	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	3970	7	between	between	IN
cord-001835-0s7ok4uw	3970	8	groups	group	NNS
cord-001835-0s7ok4uw	3970	9	of	of	IN
cord-001835-0s7ok4uw	3970	10	opposite	opposite	JJ
cord-001835-0s7ok4uw	3970	11	charges	charge	NNS
cord-001835-0s7ok4uw	3970	12	.	.	.
cord-001835-0s7ok4uw	3971	1	Net	net	JJ
cord-001835-0s7ok4uw	3971	2	interaction	interaction	NN
cord-001835-0s7ok4uw	3971	3	energy	energy	NN
cord-001835-0s7ok4uw	3971	4	(	(	-LRB-
cord-001835-0s7ok4uw	3971	5	DDGnet	DDGnet	NNP
cord-001835-0s7ok4uw	3971	6	)	)	-RRB-
cord-001835-0s7ok4uw	3971	7	of	of	IN
cord-001835-0s7ok4uw	3971	8	a	a	DT
cord-001835-0s7ok4uw	3971	9	salt	salt	NN
cord-001835-0s7ok4uw	3971	10	-	-	HYPH
cord-001835-0s7ok4uw	3971	11	bridge	bridge	NN
cord-001835-0s7ok4uw	3971	12	is	be	VBZ
cord-001835-0s7ok4uw	3971	13	partitioned	partition	VBN
cord-001835-0s7ok4uw	3971	14	into	into	IN
cord-001835-0s7ok4uw	3971	15	bridge	bridge	NN
cord-001835-0s7ok4uw	3971	16	(	(	-LRB-
cord-001835-0s7ok4uw	3971	17	DDGbrd	DDGbrd	NNP
cord-001835-0s7ok4uw	3971	18	)	)	-RRB-
cord-001835-0s7ok4uw	3971	19	,	,	,
cord-001835-0s7ok4uw	3971	20	desolvation	desolvation	NNP
cord-001835-0s7ok4uw	3971	21	(	(	-LRB-
cord-001835-0s7ok4uw	3971	22	DDGdsolv	DDGdsolv	NNP
cord-001835-0s7ok4uw	3971	23	)	)	-RRB-
cord-001835-0s7ok4uw	3971	24	and	and	CC
cord-001835-0s7ok4uw	3971	25	protein	protein	NN
cord-001835-0s7ok4uw	3971	26	(	(	-LRB-
cord-001835-0s7ok4uw	3971	27	DDGprot	DDGprot	NNP
cord-001835-0s7ok4uw	3971	28	)	)	-RRB-
cord-001835-0s7ok4uw	3971	29	energy	energy	NN
cord-001835-0s7ok4uw	3971	30	-	-	HYPH
cord-001835-0s7ok4uw	3971	31	terms	term	NNS
cord-001835-0s7ok4uw	3971	32	of	of	IN
cord-001835-0s7ok4uw	3971	33	which	which	WDT
cord-001835-0s7ok4uw	3971	34	estimation	estimation	NN
cord-001835-0s7ok4uw	3971	35	of	of	IN
cord-001835-0s7ok4uw	3971	36	DDGdsolv	DDGdsolv	NNP
cord-001835-0s7ok4uw	3971	37	and	and	CC
cord-001835-0s7ok4uw	3971	38	DDGprot	DDGprot	NNP
cord-001835-0s7ok4uw	3971	39	are	be	VBP
cord-001835-0s7ok4uw	3971	40	only	only	RB
cord-001835-0s7ok4uw	3971	41	possible	possible	JJ
cord-001835-0s7ok4uw	3971	42	by	by	IN
cord-001835-0s7ok4uw	3971	43	computational	computational	JJ
cord-001835-0s7ok4uw	3971	44	means	mean	NNS
cord-001835-0s7ok4uw	3971	45	.	.	.
cord-001835-0s7ok4uw	3972	1	Thus	thus	RB
cord-001835-0s7ok4uw	3972	2	,	,	,
cord-001835-0s7ok4uw	3972	3	general	general	JJ
cord-001835-0s7ok4uw	3972	4	purpose	purpose	NN
cord-001835-0s7ok4uw	3972	5	Poisson	Poisson	NNP
cord-001835-0s7ok4uw	3972	6	-	-	HYPH
cord-001835-0s7ok4uw	3972	7	Boltzmann	Boltzmann	NNP
cord-001835-0s7ok4uw	3972	8	Equation	Equation	NNP
cord-001835-0s7ok4uw	3972	9	solver	solver	NN
cord-001835-0s7ok4uw	3972	10	:	:	:
cord-001835-0s7ok4uw	3972	11	"	"	``
cord-001835-0s7ok4uw	3972	12	Delphi	Delphi	NNP
cord-001835-0s7ok4uw	3972	13	"	"	''
cord-001835-0s7ok4uw	3972	14	(	(	-LRB-
cord-001835-0s7ok4uw	3972	15	in	in	IN
cord-001835-0s7ok4uw	3972	16	commercial	commercial	JJ
cord-001835-0s7ok4uw	3972	17	package	package	NN
cord-001835-0s7ok4uw	3972	18	of	of	IN
cord-001835-0s7ok4uw	3972	19	INSIGHT	INSIGHT	NNP
cord-001835-0s7ok4uw	3972	20	-	-	HYPH
cord-001835-0s7ok4uw	3972	21	II	II	NNP
cord-001835-0s7ok4uw	3972	22	)	)	-RRB-
cord-001835-0s7ok4uw	3972	23	and	and	CC
cord-001835-0s7ok4uw	3972	24	"	"	``
cord-001835-0s7ok4uw	3972	25	APBS	apb	NNS
cord-001835-0s7ok4uw	3972	26	"	"	''
cord-001835-0s7ok4uw	3972	27	(	(	-LRB-
cord-001835-0s7ok4uw	3972	28	Open	open	JJ
cord-001835-0s7ok4uw	3972	29	-	-	HYPH
cord-001835-0s7ok4uw	3972	30	source	source	NN
cord-001835-0s7ok4uw	3972	31	)	)	-RRB-
cord-001835-0s7ok4uw	3972	32	are	be	VBP
cord-001835-0s7ok4uw	3972	33	popularly	popularly	RB
cord-001835-0s7ok4uw	3972	34	used	use	VBN
cord-001835-0s7ok4uw	3972	35	to	to	TO
cord-001835-0s7ok4uw	3972	36	determine	determine	VB
cord-001835-0s7ok4uw	3972	37	these	these	DT
cord-001835-0s7ok4uw	3972	38	energy	energy	NN
cord-001835-0s7ok4uw	3972	39	-	-	HYPH
cord-001835-0s7ok4uw	3972	40	terms	term	NNS
cord-001835-0s7ok4uw	3972	41	.	.	.
cord-001835-0s7ok4uw	3973	1	Nevertheless	nevertheless	RB
cord-001835-0s7ok4uw	3973	2	,	,	,
cord-001835-0s7ok4uw	3973	3	the	the	DT
cord-001835-0s7ok4uw	3973	4	computation	computation	NN
cord-001835-0s7ok4uw	3973	5	-	-	HYPH
cord-001835-0s7ok4uw	3973	6	method	method	NN
cord-001835-0s7ok4uw	3973	7	is	be	VBZ
cord-001835-0s7ok4uw	3973	8	highly	highly	RB
cord-001835-0s7ok4uw	3973	9	involved	involve	VBN
cord-001835-0s7ok4uw	3973	10	one	one	CD
cord-001835-0s7ok4uw	3973	11	than	than	IN
cord-001835-0s7ok4uw	3973	12	other	other	JJ
cord-001835-0s7ok4uw	3973	13	uses	use	NNS
cord-001835-0s7ok4uw	3973	14	of	of	IN
cord-001835-0s7ok4uw	3973	15	these	these	DT
cord-001835-0s7ok4uw	3973	16	solvers	solver	NNS
cord-001835-0s7ok4uw	3973	17	.	.	.
cord-001835-0s7ok4uw	3974	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	3974	2	,	,	,
cord-001835-0s7ok4uw	3974	3	protein	protein	NN
cord-001835-0s7ok4uw	3974	4	-	-	HYPH
cord-001835-0s7ok4uw	3974	5	specific	specific	JJ
cord-001835-0s7ok4uw	3974	6	saltbridges	saltbridge	NNS
cord-001835-0s7ok4uw	3974	7	,	,	,
cord-001835-0s7ok4uw	3974	8	grid	grid	NN
cord-001835-0s7ok4uw	3974	9	-	-	HYPH
cord-001835-0s7ok4uw	3974	10	points	point	NNS
cord-001835-0s7ok4uw	3974	11	,	,	,
cord-001835-0s7ok4uw	3974	12	center	center	NN
cord-001835-0s7ok4uw	3974	13	,	,	,
cord-001835-0s7ok4uw	3974	14	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3974	15	-	-	HYPH
cord-001835-0s7ok4uw	3974	16	isosteres	isostere	NNS
cord-001835-0s7ok4uw	3974	17	-	-	HYPH
cord-001835-0s7ok4uw	3974	18	mediated	mediate	VBN
cord-001835-0s7ok4uw	3974	19	mutation	mutation	NN
cord-001835-0s7ok4uw	3974	20	-	-	HYPH
cord-001835-0s7ok4uw	3974	21	files	file	NNS
cord-001835-0s7ok4uw	3974	22	of	of	IN
cord-001835-0s7ok4uw	3974	23	original	original	JJ
cord-001835-0s7ok4uw	3974	24	charge	charge	NN
cord-001835-0s7ok4uw	3974	25	-	-	HYPH
cord-001835-0s7ok4uw	3974	26	radius	radius	NN
cord-001835-0s7ok4uw	3974	27	file	file	NN
cord-001835-0s7ok4uw	3974	28	and	and	CC
cord-001835-0s7ok4uw	3974	29	others	other	NNS
cord-001835-0s7ok4uw	3974	30	are	be	VBP
cord-001835-0s7ok4uw	3974	31	to	to	TO
cord-001835-0s7ok4uw	3974	32	be	be	VB
cord-001835-0s7ok4uw	3974	33	worked	work	VBN
cord-001835-0s7ok4uw	3974	34	out	out	RP
cord-001835-0s7ok4uw	3974	35	prior	prior	RB
cord-001835-0s7ok4uw	3974	36	to	to	IN
cord-001835-0s7ok4uw	3974	37	the	the	DT
cord-001835-0s7ok4uw	3974	38	computation	computation	NN
cord-001835-0s7ok4uw	3974	39	.	.	.
cord-001835-0s7ok4uw	3975	1	This	this	DT
cord-001835-0s7ok4uw	3975	2	might	may	MD
cord-001835-0s7ok4uw	3975	3	answer	answer	VB
cord-001835-0s7ok4uw	3975	4	as	as	IN
cord-001835-0s7ok4uw	3975	5	to	to	IN
cord-001835-0s7ok4uw	3975	6	why	why	WRB
cord-001835-0s7ok4uw	3975	7	only	only	RB
cord-001835-0s7ok4uw	3975	8	limited	limited	JJ
cord-001835-0s7ok4uw	3975	9	numbers	number	NNS
cord-001835-0s7ok4uw	3975	10	of	of	IN
cord-001835-0s7ok4uw	3975	11	structure	structure	NN
cord-001835-0s7ok4uw	3975	12	files	file	NNS
cord-001835-0s7ok4uw	3975	13	(	(	-LRB-
cord-001835-0s7ok4uw	3975	14	2	2	CD
cord-001835-0s7ok4uw	3975	15	%	%	NN
cord-001835-0s7ok4uw	3975	16	of	of	IN
cord-001835-0s7ok4uw	3975	17	crystal	crystal	NN
cord-001835-0s7ok4uw	3975	18	-	-	HYPH
cord-001835-0s7ok4uw	3975	19	structure	structure	NN
cord-001835-0s7ok4uw	3975	20	-	-	HYPH
cord-001835-0s7ok4uw	3975	21	database	database	NN
cord-001835-0s7ok4uw	3975	22	)	)	-RRB-
cord-001835-0s7ok4uw	3975	23	are	be	VBP
cord-001835-0s7ok4uw	3975	24	worked	work	VBN
cord-001835-0s7ok4uw	3975	25	out	out	RP
cord-001835-0s7ok4uw	3975	26	till	till	IN
cord-001835-0s7ok4uw	3975	27	date	date	NN
cord-001835-0s7ok4uw	3975	28	.	.	.
cord-001835-0s7ok4uw	3976	1	At	at	IN
cord-001835-0s7ok4uw	3976	2	this	this	DT
cord-001835-0s7ok4uw	3976	3	juncture	juncture	NN
cord-001835-0s7ok4uw	3976	4	,	,	,
cord-001835-0s7ok4uw	3976	5	an	an	DT
cord-001835-0s7ok4uw	3976	6	efficient	efficient	JJ
cord-001835-0s7ok4uw	3976	7	fully	fully	RB
cord-001835-0s7ok4uw	3976	8	automated	automate	VBN
cord-001835-0s7ok4uw	3976	9	all	all	RB
cord-001835-0s7ok4uw	3976	10	-	-	HYPH
cord-001835-0s7ok4uw	3976	11	in	in	IN
cord-001835-0s7ok4uw	3976	12	-	-	HYPH
cord-001835-0s7ok4uw	3976	13	one	one	CD
cord-001835-0s7ok4uw	3976	14	-	-	HYPH
cord-001835-0s7ok4uw	3976	15	procedure	procedure	NN
cord-001835-0s7ok4uw	3976	16	that	that	WDT
cord-001835-0s7ok4uw	3976	17	could	could	MD
cord-001835-0s7ok4uw	3976	18	analyze	analyze	VB
cord-001835-0s7ok4uw	3976	19	large	large	JJ
cord-001835-0s7ok4uw	3976	20	dataset	dataset	NN
cord-001835-0s7ok4uw	3976	21	in	in	IN
cord-001835-0s7ok4uw	3976	22	a	a	DT
cord-001835-0s7ok4uw	3976	23	single	single	JJ
cord-001835-0s7ok4uw	3976	24	run	run	NN
cord-001835-0s7ok4uw	3976	25	would	would	MD
cord-001835-0s7ok4uw	3976	26	be	be	VB
cord-001835-0s7ok4uw	3976	27	useful	useful	JJ
cord-001835-0s7ok4uw	3976	28	.	.	.
cord-001835-0s7ok4uw	3977	1	To	to	IN
cord-001835-0s7ok4uw	3977	2	the	the	DT
cord-001835-0s7ok4uw	3977	3	best	good	JJS
cord-001835-0s7ok4uw	3977	4	of	of	IN
cord-001835-0s7ok4uw	3977	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3977	6	knowledge	knowledge	NN
cord-001835-0s7ok4uw	3977	7	,	,	,
cord-001835-0s7ok4uw	3977	8	such	such	JJ
cord-001835-0s7ok4uw	3977	9	procedure	procedure	NN
cord-001835-0s7ok4uw	3977	10	is	be	VBZ
cord-001835-0s7ok4uw	3977	11	truly	truly	RB
cord-001835-0s7ok4uw	3977	12	lacking	lack	VBG
cord-001835-0s7ok4uw	3977	13	in	in	IN
cord-001835-0s7ok4uw	3977	14	public	public	JJ
cord-001835-0s7ok4uw	3977	15	domain	domain	NN
cord-001835-0s7ok4uw	3977	16	.	.	.
cord-001835-0s7ok4uw	3978	1	At	at	IN
cord-001835-0s7ok4uw	3978	2	this	this	DT
cord-001835-0s7ok4uw	3978	3	end	end	NN
cord-001835-0s7ok4uw	3978	4	,	,	,
cord-001835-0s7ok4uw	3978	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3978	6	fully	fully	RB
cord-001835-0s7ok4uw	3978	7	automated	automate	VBN
cord-001835-0s7ok4uw	3978	8	all	all	RB
cord-001835-0s7ok4uw	3978	9	-	-	HYPH
cord-001835-0s7ok4uw	3978	10	in	in	IN
cord-001835-0s7ok4uw	3978	11	-	-	HYPH
cord-001835-0s7ok4uw	3978	12	one	one	CD
cord-001835-0s7ok4uw	3978	13	procedure	procedure	NN
cord-001835-0s7ok4uw	3978	14	:	:	:
cord-001835-0s7ok4uw	3978	15	ADSETMEAS	ADSETMEAS	NNP
cord-001835-0s7ok4uw	3978	16	(	(	-LRB-
cord-001835-0s7ok4uw	3978	17	available	available	JJ
cord-001835-0s7ok4uw	3978	18	freely	freely	RB
cord-001835-0s7ok4uw	3978	19	at	at	IN
cord-001835-0s7ok4uw	3978	20	http://sourceforge.net/projects/ADSETMEAS/along	http://sourceforge.net/projects/ADSETMEAS/along	VBG
cord-001835-0s7ok4uw	3978	21	with	with	IN
cord-001835-0s7ok4uw	3978	22	detailed	detailed	JJ
cord-001835-0s7ok4uw	3978	23	documentation	documentation	NN
cord-001835-0s7ok4uw	3978	24	)	)	-RRB-
cord-001835-0s7ok4uw	3978	25	uses	use	VBZ
cord-001835-0s7ok4uw	3978	26	"	"	``
cord-001835-0s7ok4uw	3978	27	APBS	APBS	NNP
cord-001835-0s7ok4uw	3978	28	"	"	''
cord-001835-0s7ok4uw	3978	29	method	method	NN
cord-001835-0s7ok4uw	3978	30	to	to	TO
cord-001835-0s7ok4uw	3978	31	compute	compute	VB
cord-001835-0s7ok4uw	3978	32	component	component	NN
cord-001835-0s7ok4uw	3978	33	as	as	RB
cord-001835-0s7ok4uw	3978	34	well	well	RB
cord-001835-0s7ok4uw	3978	35	as	as	IN
cord-001835-0s7ok4uw	3978	36	net	net	JJ
cord-001835-0s7ok4uw	3978	37	energy	energy	NN
cord-001835-0s7ok4uw	3978	38	-	-	HYPH
cord-001835-0s7ok4uw	3978	39	terms	term	NNS
cord-001835-0s7ok4uw	3978	40	of	of	IN
cord-001835-0s7ok4uw	3978	41	salt	salt	NN
cord-001835-0s7ok4uw	3978	42	-	-	HYPH
cord-001835-0s7ok4uw	3978	43	bridges	bridge	NNS
cord-001835-0s7ok4uw	3978	44	and	and	CC
cord-001835-0s7ok4uw	3978	45	redirect	redirect	VB
cord-001835-0s7ok4uw	3978	46	compact	compact	JJ
cord-001835-0s7ok4uw	3978	47	output	output	NN
cord-001835-0s7ok4uw	3978	48	in	in	IN
cord-001835-0s7ok4uw	3978	49	excelformat	excelformat	NN
cord-001835-0s7ok4uw	3978	50	.	.	.
cord-001835-0s7ok4uw	3979	1	Further	further	RB
cord-001835-0s7ok4uw	3979	2	,	,	,
cord-001835-0s7ok4uw	3979	3	micro	micro	NNS
cord-001835-0s7ok4uw	3979	4	-	-	NNS
cord-001835-0s7ok4uw	3979	5	environments	environment	NNS
cord-001835-0s7ok4uw	3979	6	of	of	IN
cord-001835-0s7ok4uw	3979	7	salt	salt	NN
cord-001835-0s7ok4uw	3979	8	-	-	HYPH
cord-001835-0s7ok4uw	3979	9	bridges	bridge	NNS
cord-001835-0s7ok4uw	3979	10	are	be	VBP
cord-001835-0s7ok4uw	3979	11	also	also	RB
cord-001835-0s7ok4uw	3979	12	been	be	VBN
cord-001835-0s7ok4uw	3979	13	reported	report	VBN
cord-001835-0s7ok4uw	3979	14	based	base	VBN
cord-001835-0s7ok4uw	3979	15	on	on	IN
cord-001835-0s7ok4uw	3979	16	the	the	DT
cord-001835-0s7ok4uw	3979	17	presence	presence	NN
cord-001835-0s7ok4uw	3979	18	of	of	IN
cord-001835-0s7ok4uw	3979	19	polar	polar	JJ
cord-001835-0s7ok4uw	3979	20	,	,	,
cord-001835-0s7ok4uw	3979	21	dipolar	dipolar	JJ
cord-001835-0s7ok4uw	3979	22	,	,	,
cord-001835-0s7ok4uw	3979	23	acidic	acidic	JJ
cord-001835-0s7ok4uw	3979	24	,	,	,
cord-001835-0s7ok4uw	3979	25	basic	basic	JJ
cord-001835-0s7ok4uw	3979	26	and	and	CC
cord-001835-0s7ok4uw	3979	27	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	3979	28	side	side	NN
cord-001835-0s7ok4uw	3979	29	-	-	HYPH
cord-001835-0s7ok4uw	3979	30	chains	chain	NNS
cord-001835-0s7ok4uw	3979	31	in	in	IN
cord-001835-0s7ok4uw	3979	32	their	-PRON-	PRP$
cord-001835-0s7ok4uw	3979	33	proximity	proximity	NN
cord-001835-0s7ok4uw	3979	34	.	.	.
cord-001835-0s7ok4uw	3980	1	The	the	DT
cord-001835-0s7ok4uw	3980	2	procedure	procedure	NN
cord-001835-0s7ok4uw	3980	3	provides	provide	VBZ
cord-001835-0s7ok4uw	3980	4	versatility	versatility	NN
cord-001835-0s7ok4uw	3980	5	to	to	IN
cord-001835-0s7ok4uw	3980	6	users	user	NNS
cord-001835-0s7ok4uw	3980	7	in	in	IN
cord-001835-0s7ok4uw	3980	8	choosing	choose	VBG
cord-001835-0s7ok4uw	3980	9	a	a	DT
cord-001835-0s7ok4uw	3980	10	]	]	-RRB-
cord-001835-0s7ok4uw	3980	11	model	model	NN
cord-001835-0s7ok4uw	3980	12	for	for	IN
cord-001835-0s7ok4uw	3980	13	computation	computation	NN
cord-001835-0s7ok4uw	3980	14	of	of	IN
cord-001835-0s7ok4uw	3980	15	energy	energy	NN
cord-001835-0s7ok4uw	3980	16	-	-	HYPH
cord-001835-0s7ok4uw	3980	17	terms	term	NNS
cord-001835-0s7ok4uw	3980	18	to	to	IN
cord-001835-0s7ok4uw	3980	19	-	-	HYPH
cord-001835-0s7ok4uw	3980	20	date	date	NN
cord-001835-0s7ok4uw	3980	21	available	available	JJ
cord-001835-0s7ok4uw	3980	22	in	in	IN
cord-001835-0s7ok4uw	3980	23	the	the	DT
cord-001835-0s7ok4uw	3980	24	literature	literature	NN
cord-001835-0s7ok4uw	3980	25	and	and	CC
cord-001835-0s7ok4uw	3980	26	b	b	LS
cord-001835-0s7ok4uw	3980	27	]	]	-RRB-
cord-001835-0s7ok4uw	3980	28	method	method	NN
cord-001835-0s7ok4uw	3980	29	(	(	-LRB-
cord-001835-0s7ok4uw	3980	30	default	default	NN
cord-001835-0s7ok4uw	3980	31	or	or	CC
cord-001835-0s7ok4uw	3980	32	advanced	advanced	JJ
cord-001835-0s7ok4uw	3980	33	)	)	-RRB-
cord-001835-0s7ok4uw	3980	34	for	for	IN
cord-001835-0s7ok4uw	3980	35	parametric	parametric	JJ
cord-001835-0s7ok4uw	3980	36	optimization	optimization	NN
cord-001835-0s7ok4uw	3980	37	in	in	IN
cord-001835-0s7ok4uw	3980	38	"	"	``
cord-001835-0s7ok4uw	3980	39	APBS	APBS	NNP
cord-001835-0s7ok4uw	3980	40	"	"	''
cord-001835-0s7ok4uw	3980	41	calculations	calculation	NNS
cord-001835-0s7ok4uw	3980	42	.	.	.
cord-001835-0s7ok4uw	3981	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3981	2	works	work	VBZ
cord-001835-0s7ok4uw	3981	3	in	in	IN
cord-001835-0s7ok4uw	3981	4	UNIX	UNIX	NNP
cord-001835-0s7ok4uw	3981	5	like	like	IN
cord-001835-0s7ok4uw	3981	6	environment	environment	NN
cord-001835-0s7ok4uw	3981	7	including	include	VBG
cord-001835-0s7ok4uw	3981	8	CYGWIN	CYGWIN	NNP
cord-001835-0s7ok4uw	3981	9	.	.	.
cord-001835-0s7ok4uw	3982	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	3982	2	processes	process	VBZ
cord-001835-0s7ok4uw	3982	3	all	all	DT
cord-001835-0s7ok4uw	3982	4	proteins	protein	NNS
cord-001835-0s7ok4uw	3982	5	present	present	JJ
cord-001835-0s7ok4uw	3982	6	in	in	IN
cord-001835-0s7ok4uw	3982	7	the	the	DT
cord-001835-0s7ok4uw	3982	8	working	work	VBG
cord-001835-0s7ok4uw	3982	9	directory	directory	NN
cord-001835-0s7ok4uw	3982	10	with	with	IN
cord-001835-0s7ok4uw	3982	11	any	any	DT
cord-001835-0s7ok4uw	3982	12	number	number	NN
cord-001835-0s7ok4uw	3982	13	of	of	IN
cord-001835-0s7ok4uw	3982	14	salt	salt	NN
cord-001835-0s7ok4uw	3982	15	-	-	HYPH
cord-001835-0s7ok4uw	3982	16	bridges	bridge	NNS
cord-001835-0s7ok4uw	3982	17	in	in	IN
cord-001835-0s7ok4uw	3982	18	them	-PRON-	PRP
cord-001835-0s7ok4uw	3982	19	.	.	.
cord-001835-0s7ok4uw	3983	1	A	a	DT
cord-001835-0s7ok4uw	3983	2	pre	pre	JJ
cord-001835-0s7ok4uw	3983	3	-	-	JJ
cord-001835-0s7ok4uw	3983	4	released	release	VBN
cord-001835-0s7ok4uw	3983	5	version	version	NN
cord-001835-0s7ok4uw	3983	6	of	of	IN
cord-001835-0s7ok4uw	3983	7	the	the	DT
cord-001835-0s7ok4uw	3983	8	procedure	procedure	NN
cord-001835-0s7ok4uw	3983	9	was	be	VBD
cord-001835-0s7ok4uw	3983	10	successfully	successfully	RB
cord-001835-0s7ok4uw	3983	11	applied	apply	VBN
cord-001835-0s7ok4uw	3983	12	for	for	IN
cord-001835-0s7ok4uw	3983	13	energy	energy	NN
cord-001835-0s7ok4uw	3983	14	-	-	HYPH
cord-001835-0s7ok4uw	3983	15	terms	term	NNS
cord-001835-0s7ok4uw	3983	16	on	on	IN
cord-001835-0s7ok4uw	3983	17	220	220	CD
cord-001835-0s7ok4uw	3983	18	salt	salt	NN
cord-001835-0s7ok4uw	3983	19	-	-	HYPH
cord-001835-0s7ok4uw	3983	20	bridges	bridge	NNS
cord-001835-0s7ok4uw	3983	21	from	from	IN
cord-001835-0s7ok4uw	3983	22	22	22	CD
cord-001835-0s7ok4uw	3983	23	halophilic	halophilic	NNP
cord-001835-0s7ok4uw	3983	24	proteins	protein	NNS
cord-001835-0s7ok4uw	3983	25	.	.	.
cord-001835-0s7ok4uw	3984	1	Overall	overall	RB
cord-001835-0s7ok4uw	3984	2	,	,	,
cord-001835-0s7ok4uw	3984	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	3984	4	ADSETMEAS	ADSETMEAS	NNP
cord-001835-0s7ok4uw	3984	5	provides	provide	VBZ
cord-001835-0s7ok4uw	3984	6	intricate	intricate	JJ
cord-001835-0s7ok4uw	3984	7	details	detail	NNS
cord-001835-0s7ok4uw	3984	8	on	on	IN
cord-001835-0s7ok4uw	3984	9	salt	salt	NN
cord-001835-0s7ok4uw	3984	10	-	-	HYPH
cord-001835-0s7ok4uw	3984	11	bridge	bridge	NN
cord-001835-0s7ok4uw	3984	12	energetic	energetic	JJ
cord-001835-0s7ok4uw	3984	13	from	from	IN
cord-001835-0s7ok4uw	3984	14	crystal	crystal	NN
cord-001835-0s7ok4uw	3984	15	structures	structure	NNS
cord-001835-0s7ok4uw	3984	16	and	and	CC
cord-001835-0s7ok4uw	3984	17	find	find	VB
cord-001835-0s7ok4uw	3984	18	application	application	NN
cord-001835-0s7ok4uw	3984	19	in	in	IN
cord-001835-0s7ok4uw	3984	20	the	the	DT
cord-001835-0s7ok4uw	3984	21	field	field	NN
cord-001835-0s7ok4uw	3984	22	of	of	IN
cord-001835-0s7ok4uw	3984	23	computational	computational	JJ
cord-001835-0s7ok4uw	3984	24	structural	structural	JJ
cord-001835-0s7ok4uw	3984	25	biology	biology	NN
cord-001835-0s7ok4uw	3984	26	.	.	.
cord-001835-0s7ok4uw	3985	1	These	these	DT
cord-001835-0s7ok4uw	3985	2	and	and	CC
cord-001835-0s7ok4uw	3985	3	other	other	JJ
cord-001835-0s7ok4uw	3985	4	results	result	NNS
cord-001835-0s7ok4uw	3985	5	will	will	MD
cord-001835-0s7ok4uw	3985	6	be	be	VB
cord-001835-0s7ok4uw	3985	7	discussed	discuss	VBN
cord-001835-0s7ok4uw	3985	8	in	in	IN
cord-001835-0s7ok4uw	3985	9	the	the	DT
cord-001835-0s7ok4uw	3985	10	conference	conference	NN
cord-001835-0s7ok4uw	3985	11	.	.	.
cord-001835-0s7ok4uw	3986	1	Next	next	JJ
cord-001835-0s7ok4uw	3986	2	generation	generation	NN
cord-001835-0s7ok4uw	3986	3	analgesics	analgesic	NNS
cord-001835-0s7ok4uw	3986	4	-targeting	-targete	VBG
cord-001835-0s7ok4uw	3986	5	ion	ion	NN
cord-001835-0s7ok4uw	3986	6	channels	channel	NNS
cord-001835-0s7ok4uw	3986	7	with	with	IN
cord-001835-0s7ok4uw	3986	8	antibody	antibody	NN
cord-001835-0s7ok4uw	3986	9	-	-	HYPH
cord-001835-0s7ok4uw	3986	10	drug	drug	NN
cord-001835-0s7ok4uw	3986	11	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	3986	12	(	(	-LRB-
cord-001835-0s7ok4uw	3986	13	ADCs	ADCs	NNP
cord-001835-0s7ok4uw	3986	14	)	)	-RRB-
cord-001835-0s7ok4uw	3987	1	Anna	Anna	NNP
cord-001835-0s7ok4uw	3987	2	Wojciechowska	Wojciechowska	NNP
cord-001835-0s7ok4uw	3987	3	-	-	HYPH
cord-001835-0s7ok4uw	3987	4	Bason	Bason	NNP
cord-001835-0s7ok4uw	3987	5	1	1	CD
cord-001835-0s7ok4uw	3987	6	,	,	,
cord-001835-0s7ok4uw	3987	7	Clare	Clare	NNP
cord-001835-0s7ok4uw	3987	8	Jones	Jones	NNP
cord-001835-0s7ok4uw	3987	9	2	2	CD
cord-001835-0s7ok4uw	3987	10	,	,	,
cord-001835-0s7ok4uw	3987	11	Chris	Chris	NNP
cord-001835-0s7ok4uw	3987	12	Lloyd	Lloyd	NNP
cord-001835-0s7ok4uw	3987	13	3	3	CD
cord-001835-0s7ok4uw	3987	14	1	1	CD
cord-001835-0s7ok4uw	3987	15	Postdoctoral	Postdoctoral	NNP
cord-001835-0s7ok4uw	3987	16	Fellow	Fellow	NNP
cord-001835-0s7ok4uw	3987	17	,	,	,
cord-001835-0s7ok4uw	3988	1	ADPE	ADPE	NNP
cord-001835-0s7ok4uw	3988	2	,	,	,
cord-001835-0s7ok4uw	3988	3	Medimmune	Medimmune	NNP
cord-001835-0s7ok4uw	3988	4	,	,	,
cord-001835-0s7ok4uw	3988	5	Cambridge	Cambridge	NNP
cord-001835-0s7ok4uw	3988	6	,	,	,
cord-001835-0s7ok4uw	3988	7	2	2	CD
cord-001835-0s7ok4uw	3988	8	RIA	RIA	NNP
cord-001835-0s7ok4uw	3988	9	,	,	,
cord-001835-0s7ok4uw	3988	10	Medimmune	Medimmune	NNP
cord-001835-0s7ok4uw	3988	11	,	,	,
cord-001835-0s7ok4uw	3988	12	Cambridge	Cambridge	NNP
cord-001835-0s7ok4uw	3988	13	,	,	,
cord-001835-0s7ok4uw	3988	14	3	3	CD
cord-001835-0s7ok4uw	3988	15	ADPE	ADPE	NNP
cord-001835-0s7ok4uw	3988	16	Ion	ion	NN
cord-001835-0s7ok4uw	3988	17	channels	channel	NNS
cord-001835-0s7ok4uw	3988	18	are	be	VBP
cord-001835-0s7ok4uw	3988	19	common	common	JJ
cord-001835-0s7ok4uw	3988	20	targets	target	NNS
cord-001835-0s7ok4uw	3988	21	for	for	IN
cord-001835-0s7ok4uw	3988	22	chronic	chronic	JJ
cord-001835-0s7ok4uw	3988	23	pain	pain	NN
cord-001835-0s7ok4uw	3988	24	therapies	therapy	NNS
cord-001835-0s7ok4uw	3988	25	.	.	.
cord-001835-0s7ok4uw	3989	1	Small	small	JJ
cord-001835-0s7ok4uw	3989	2	molecule	molecule	NN
cord-001835-0s7ok4uw	3989	3	analgesics	analgesic	NNS
cord-001835-0s7ok4uw	3989	4	are	be	VBP
cord-001835-0s7ok4uw	3989	5	widely	widely	RB
cord-001835-0s7ok4uw	3989	6	used	use	VBN
cord-001835-0s7ok4uw	3989	7	therapeutically	therapeutically	RB
cord-001835-0s7ok4uw	3989	8	,	,	,
cord-001835-0s7ok4uw	3989	9	but	but	CC
cord-001835-0s7ok4uw	3989	10	due	due	IN
cord-001835-0s7ok4uw	3989	11	to	to	IN
cord-001835-0s7ok4uw	3989	12	poor	poor	JJ
cord-001835-0s7ok4uw	3989	13	specificity	specificity	NN
cord-001835-0s7ok4uw	3989	14	they	-PRON-	PRP
cord-001835-0s7ok4uw	3989	15	often	often	RB
cord-001835-0s7ok4uw	3989	16	cause	cause	VBP
cord-001835-0s7ok4uw	3989	17	a	a	DT
cord-001835-0s7ok4uw	3989	18	wide	wide	JJ
cord-001835-0s7ok4uw	3989	19	range	range	NN
cord-001835-0s7ok4uw	3989	20	of	of	IN
cord-001835-0s7ok4uw	3989	21	side	side	NN
cord-001835-0s7ok4uw	3989	22	effects	effect	NNS
cord-001835-0s7ok4uw	3989	23	.	.	.
cord-001835-0s7ok4uw	3990	1	As	as	IN
cord-001835-0s7ok4uw	3990	2	a	a	DT
cord-001835-0s7ok4uw	3990	3	result	result	NN
cord-001835-0s7ok4uw	3990	4	,	,	,
cord-001835-0s7ok4uw	3990	5	efficacy	efficacy	NN
cord-001835-0s7ok4uw	3990	6	of	of	IN
cord-001835-0s7ok4uw	3990	7	existing	exist	VBG
cord-001835-0s7ok4uw	3990	8	treatments	treatment	NNS
cord-001835-0s7ok4uw	3990	9	is	be	VBZ
cord-001835-0s7ok4uw	3990	10	very	very	RB
cord-001835-0s7ok4uw	3990	11	limited	limited	JJ
cord-001835-0s7ok4uw	3990	12	.	.	.
cord-001835-0s7ok4uw	3991	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	3991	2	believe	believe	VBP
cord-001835-0s7ok4uw	3991	3	that	that	IN
cord-001835-0s7ok4uw	3991	4	to	to	TO
cord-001835-0s7ok4uw	3991	5	achieve	achieve	VB
cord-001835-0s7ok4uw	3991	6	the	the	DT
cord-001835-0s7ok4uw	3991	7	required	require	VBN
cord-001835-0s7ok4uw	3991	8	specificity	specificity	NN
cord-001835-0s7ok4uw	3991	9	and	and	CC
cord-001835-0s7ok4uw	3991	10	efficacy	efficacy	NN
cord-001835-0s7ok4uw	3991	11	,	,	,
cord-001835-0s7ok4uw	3991	12	a	a	DT
cord-001835-0s7ok4uw	3991	13	novel	novel	JJ
cord-001835-0s7ok4uw	3991	14	and	and	CC
cord-001835-0s7ok4uw	3991	15	innovative	innovative	JJ
cord-001835-0s7ok4uw	3991	16	approach	approach	NN
cord-001835-0s7ok4uw	3991	17	is	be	VBZ
cord-001835-0s7ok4uw	3991	18	required	require	VBN
cord-001835-0s7ok4uw	3991	19	that	that	WDT
cord-001835-0s7ok4uw	3991	20	would	would	MD
cord-001835-0s7ok4uw	3991	21	combine	combine	VB
cord-001835-0s7ok4uw	3991	22	the	the	DT
cord-001835-0s7ok4uw	3991	23	potency	potency	NN
cord-001835-0s7ok4uw	3991	24	of	of	IN
cord-001835-0s7ok4uw	3991	25	the	the	DT
cord-001835-0s7ok4uw	3991	26	small	small	JJ
cord-001835-0s7ok4uw	3991	27	molecule	molecule	NN
cord-001835-0s7ok4uw	3991	28	with	with	IN
cord-001835-0s7ok4uw	3991	29	the	the	DT
cord-001835-0s7ok4uw	3991	30	selectivity	selectivity	NN
cord-001835-0s7ok4uw	3991	31	of	of	IN
cord-001835-0s7ok4uw	3991	32	an	an	DT
cord-001835-0s7ok4uw	3991	33	antibody	antibody	NN
cord-001835-0s7ok4uw	3991	34	.	.	.
cord-001835-0s7ok4uw	3992	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	3992	2	,	,	,
cord-001835-0s7ok4uw	3992	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	3992	4	propose	propose	VBP
cord-001835-0s7ok4uw	3992	5	to	to	TO
cord-001835-0s7ok4uw	3992	6	apply	apply	VB
cord-001835-0s7ok4uw	3992	7	antibody	antibody	NN
cord-001835-0s7ok4uw	3992	8	-	-	HYPH
cord-001835-0s7ok4uw	3992	9	drug	drug	NN
cord-001835-0s7ok4uw	3992	10	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	3992	11	(	(	-LRB-
cord-001835-0s7ok4uw	3992	12	ADCs	adc	NNS
cord-001835-0s7ok4uw	3992	13	)	)	-RRB-
cord-001835-0s7ok4uw	3992	14	to	to	TO
cord-001835-0s7ok4uw	3992	15	deliver	deliver	VB
cord-001835-0s7ok4uw	3992	16	small	small	JJ
cord-001835-0s7ok4uw	3992	17	molecules	molecule	NNS
cord-001835-0s7ok4uw	3992	18	or	or	CC
cord-001835-0s7ok4uw	3992	19	peptides	peptide	NNS
cord-001835-0s7ok4uw	3992	20	to	to	TO
cord-001835-0s7ok4uw	3992	21	ion	ion	NN
cord-001835-0s7ok4uw	3992	22	channels	channel	NNS
cord-001835-0s7ok4uw	3992	23	in	in	IN
cord-001835-0s7ok4uw	3992	24	order	order	NN
cord-001835-0s7ok4uw	3992	25	to	to	TO
cord-001835-0s7ok4uw	3992	26	specifically	specifically	RB
cord-001835-0s7ok4uw	3992	27	modulate	modulate	VB
cord-001835-0s7ok4uw	3992	28	pain	pain	NN
cord-001835-0s7ok4uw	3992	29	signalling	signal	VBG
cord-001835-0s7ok4uw	3992	30	pathways	pathway	NNS
cord-001835-0s7ok4uw	3992	31	.	.	.
cord-001835-0s7ok4uw	3993	1	Voltage	voltage	VB
cord-001835-0s7ok4uw	3993	2	-	-	HYPH
cord-001835-0s7ok4uw	3993	3	gated	gate	VBN
cord-001835-0s7ok4uw	3993	4	sodium	sodium	NN
cord-001835-0s7ok4uw	3993	5	channel	channel	NN
cord-001835-0s7ok4uw	3993	6	Nav1.7	Nav1.7	NNP
cord-001835-0s7ok4uw	3993	7	has	have	VBZ
cord-001835-0s7ok4uw	3993	8	a	a	DT
cord-001835-0s7ok4uw	3993	9	well	well	RB
cord-001835-0s7ok4uw	3993	10	characterised	characterise	VBN
cord-001835-0s7ok4uw	3993	11	role	role	NN
cord-001835-0s7ok4uw	3993	12	in	in	IN
cord-001835-0s7ok4uw	3993	13	the	the	DT
cord-001835-0s7ok4uw	3993	14	perception	perception	NN
cord-001835-0s7ok4uw	3993	15	of	of	IN
cord-001835-0s7ok4uw	3993	16	pain	pain	NN
cord-001835-0s7ok4uw	3993	17	.	.	.
cord-001835-0s7ok4uw	3994	1	Here	here	RB
cord-001835-0s7ok4uw	3994	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	3994	3	present	present	VBP
cord-001835-0s7ok4uw	3994	4	the	the	DT
cord-001835-0s7ok4uw	3994	5	activity	activity	NN
cord-001835-0s7ok4uw	3994	6	of	of	IN
cord-001835-0s7ok4uw	3994	7	the	the	DT
cord-001835-0s7ok4uw	3994	8	peptide	peptide	JJ
cord-001835-0s7ok4uw	3994	9	Huwentoxin	Huwentoxin	NNP
cord-001835-0s7ok4uw	3994	10	-	-	HYPH
cord-001835-0s7ok4uw	3994	11	IV	IV	NNP
cord-001835-0s7ok4uw	3994	12	(	(	-LRB-
cord-001835-0s7ok4uw	3994	13	HWTX	HWTX	NNP
cord-001835-0s7ok4uw	3994	14	-	-	HYPH
cord-001835-0s7ok4uw	3994	15	IV	IV	NNP
cord-001835-0s7ok4uw	3994	16	)	)	-RRB-
cord-001835-0s7ok4uw	3994	17	and	and	CC
cord-001835-0s7ok4uw	3994	18	small	small	JJ
cord-001835-0s7ok4uw	3994	19	molecule	molecule	NN
cord-001835-0s7ok4uw	3994	20	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	3994	21	PTC	PTC	NNP
cord-001835-0s7ok4uw	3994	22	-	-	HYPH
cord-001835-0s7ok4uw	3994	23	A	A	NNP
cord-001835-0s7ok4uw	3994	24	,	,	,
cord-001835-0s7ok4uw	3994	25	PTC	PTC	NNP
cord-001835-0s7ok4uw	3994	26	-	-	HYPH
cord-001835-0s7ok4uw	3994	27	B	B	NNP
cord-001835-0s7ok4uw	3994	28	and	and	CC
cord-001835-0s7ok4uw	3994	29	PTC	PTC	NNP
cord-001835-0s7ok4uw	3994	30	-	-	HYPH
cord-001835-0s7ok4uw	3994	31	C	C	NNP
cord-001835-0s7ok4uw	3994	32	on	on	IN
cord-001835-0s7ok4uw	3994	33	voltage	voltage	NN
cord-001835-0s7ok4uw	3994	34	gated	gated	JJ
cord-001835-0s7ok4uw	3994	35	sodium	sodium	NN
cord-001835-0s7ok4uw	3994	36	channels	channel	NNS
cord-001835-0s7ok4uw	3994	37	Nav1.7	nav1.7	NN
cord-001835-0s7ok4uw	3994	38	and	and	CC
cord-001835-0s7ok4uw	3994	39	Nav1.6	Nav1.6	NNS
cord-001835-0s7ok4uw	3994	40	.	.	.
cord-001835-0s7ok4uw	3995	1	In	in	IN
cord-001835-0s7ok4uw	3995	2	novel	novel	JJ
cord-001835-0s7ok4uw	3995	3	findings	finding	NNS
cord-001835-0s7ok4uw	3995	4	,	,	,
cord-001835-0s7ok4uw	3995	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	3995	6	report	report	VBP
cord-001835-0s7ok4uw	3995	7	that	that	IN
cord-001835-0s7ok4uw	3995	8	these	these	DT
cord-001835-0s7ok4uw	3995	9	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	3995	10	show	show	VBP
cord-001835-0s7ok4uw	3995	11	little	little	JJ
cord-001835-0s7ok4uw	3995	12	selectivity	selectivity	NN
cord-001835-0s7ok4uw	3995	13	between	between	IN
cord-001835-0s7ok4uw	3995	14	the	the	DT
cord-001835-0s7ok4uw	3995	15	voltage	voltage	NN
cord-001835-0s7ok4uw	3995	16	-	-	HYPH
cord-001835-0s7ok4uw	3995	17	gated	gate	VBN
cord-001835-0s7ok4uw	3995	18	sodium	sodium	NN
cord-001835-0s7ok4uw	3995	19	channel	channel	NN
cord-001835-0s7ok4uw	3995	20	family	family	NN
cord-001835-0s7ok4uw	3995	21	members	member	NNS
cord-001835-0s7ok4uw	3995	22	,	,	,
cord-001835-0s7ok4uw	3995	23	Nav1.6	Nav1.6	NNS
cord-001835-0s7ok4uw	3995	24	and	and	CC
cord-001835-0s7ok4uw	3995	25	Nav1.7	nav1.7	NN
cord-001835-0s7ok4uw	3995	26	,	,	,
cord-001835-0s7ok4uw	3995	27	and	and	CC
cord-001835-0s7ok4uw	3995	28	that	that	IN
cord-001835-0s7ok4uw	3995	29	the	the	DT
cord-001835-0s7ok4uw	3995	30	IC50	ic50	JJ
cord-001835-0s7ok4uw	3995	31	values	value	NNS
cord-001835-0s7ok4uw	3995	32	and	and	CC
cord-001835-0s7ok4uw	3995	33	the	the	DT
cord-001835-0s7ok4uw	3995	34	impact	impact	NN
cord-001835-0s7ok4uw	3995	35	on	on	IN
cord-001835-0s7ok4uw	3995	36	channel	channel	NNP
cord-001835-0s7ok4uw	3995	37	biophysics	biophysic	NNS
cord-001835-0s7ok4uw	3995	38	(	(	-LRB-
cord-001835-0s7ok4uw	3995	39	voltage	voltage	NN
cord-001835-0s7ok4uw	3995	40	-	-	HYPH
cord-001835-0s7ok4uw	3995	41	dependence	dependence	NN
cord-001835-0s7ok4uw	3995	42	of	of	IN
cord-001835-0s7ok4uw	3995	43	activation	activation	NN
cord-001835-0s7ok4uw	3995	44	and	and	CC
cord-001835-0s7ok4uw	3995	45	fast	fast	JJ
cord-001835-0s7ok4uw	3995	46	inactivation	inactivation	NN
cord-001835-0s7ok4uw	3995	47	)	)	-RRB-
cord-001835-0s7ok4uw	3995	48	of	of	IN
cord-001835-0s7ok4uw	3995	49	the	the	DT
cord-001835-0s7ok4uw	3995	50	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	3995	51	are	be	VBP
cord-001835-0s7ok4uw	3995	52	largely	largely	RB
cord-001835-0s7ok4uw	3995	53	similar	similar	JJ
cord-001835-0s7ok4uw	3995	54	for	for	IN
cord-001835-0s7ok4uw	3995	55	both	both	DT
cord-001835-0s7ok4uw	3995	56	channel	channel	NN
cord-001835-0s7ok4uw	3995	57	types	type	NNS
cord-001835-0s7ok4uw	3995	58	.	.	.
cord-001835-0s7ok4uw	3996	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	3996	2	,	,	,
cord-001835-0s7ok4uw	3996	3	the	the	DT
cord-001835-0s7ok4uw	3996	4	use	use	NN
cord-001835-0s7ok4uw	3996	5	of	of	IN
cord-001835-0s7ok4uw	3996	6	HWTX	HWTX	NNP
cord-001835-0s7ok4uw	3996	7	-	-	HYPH
cord-001835-0s7ok4uw	3996	8	IV	IV	NNP
cord-001835-0s7ok4uw	3996	9	and	and	CC
cord-001835-0s7ok4uw	3996	10	other	other	JJ
cord-001835-0s7ok4uw	3996	11	small	small	JJ
cord-001835-0s7ok4uw	3996	12	molecule	molecule	NN
cord-001835-0s7ok4uw	3996	13	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	3996	14	of	of	IN
cord-001835-0s7ok4uw	3996	15	Nav1.7	nav1.7	NN
cord-001835-0s7ok4uw	3996	16	for	for	IN
cord-001835-0s7ok4uw	3996	17	pain	pain	NN
cord-001835-0s7ok4uw	3996	18	therapy	therapy	NN
cord-001835-0s7ok4uw	3996	19	could	could	MD
cord-001835-0s7ok4uw	3996	20	be	be	VB
cord-001835-0s7ok4uw	3996	21	dose	dose	NN
cord-001835-0s7ok4uw	3996	22	-	-	HYPH
cord-001835-0s7ok4uw	3996	23	limited	limited	JJ
cord-001835-0s7ok4uw	3996	24	due	due	IN
cord-001835-0s7ok4uw	3996	25	to	to	IN
cord-001835-0s7ok4uw	3996	26	side	side	JJ
cord-001835-0s7ok4uw	3996	27	effects	effect	NNS
cord-001835-0s7ok4uw	3996	28	mediated	mediate	VBN
cord-001835-0s7ok4uw	3996	29	by	by	IN
cord-001835-0s7ok4uw	3996	30	the	the	DT
cord-001835-0s7ok4uw	3996	31	inhibition	inhibition	NN
cord-001835-0s7ok4uw	3996	32	of	of	IN
cord-001835-0s7ok4uw	3996	33	channel	channel	NN
cord-001835-0s7ok4uw	3996	34	Nav1.6	Nav1.6	NNS
cord-001835-0s7ok4uw	3996	35	.	.	.
cord-001835-0s7ok4uw	3997	1	In	in	IN
cord-001835-0s7ok4uw	3997	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	3997	3	,	,	,
cord-001835-0s7ok4uw	3997	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	3997	5	propose	propose	VBP
cord-001835-0s7ok4uw	3997	6	that	that	IN
cord-001835-0s7ok4uw	3997	7	HWTX	HWTX	NNP
cord-001835-0s7ok4uw	3997	8	-	-	HYPH
cord-001835-0s7ok4uw	3997	9	IV	IV	NNP
cord-001835-0s7ok4uw	3997	10	and	and	CC
cord-001835-0s7ok4uw	3997	11	the	the	DT
cord-001835-0s7ok4uw	3997	12	investigated	investigate	VBN
cord-001835-0s7ok4uw	3997	13	small	small	JJ
cord-001835-0s7ok4uw	3997	14	molecule	molecule	NN
cord-001835-0s7ok4uw	3997	15	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	3997	16	could	could	MD
cord-001835-0s7ok4uw	3997	17	be	be	VB
cord-001835-0s7ok4uw	3997	18	used	use	VBN
cord-001835-0s7ok4uw	3997	19	for	for	IN
cord-001835-0s7ok4uw	3997	20	the	the	DT
cord-001835-0s7ok4uw	3997	21	treatment	treatment	NN
cord-001835-0s7ok4uw	3997	22	of	of	IN
cord-001835-0s7ok4uw	3997	23	pain	pain	NN
cord-001835-0s7ok4uw	3997	24	as	as	IN
cord-001835-0s7ok4uw	3997	25	part	part	NN
cord-001835-0s7ok4uw	3997	26	of	of	IN
cord-001835-0s7ok4uw	3997	27	a	a	DT
cord-001835-0s7ok4uw	3997	28	Nav1.7	Nav1.7	NNP
cord-001835-0s7ok4uw	3997	29	antibody	antibody	NN
cord-001835-0s7ok4uw	3997	30	-	-	HYPH
cord-001835-0s7ok4uw	3997	31	drug	drug	NN
cord-001835-0s7ok4uw	3997	32	conjugate	conjugate	NN
cord-001835-0s7ok4uw	3997	33	(	(	-LRB-
cord-001835-0s7ok4uw	3997	34	Nav1.7-ADC	Nav1.7-ADC	NNP
cord-001835-0s7ok4uw	3997	35	)	)	-RRB-
cord-001835-0s7ok4uw	3997	36	,	,	,
cord-001835-0s7ok4uw	3997	37	establishing	establish	VBG
cord-001835-0s7ok4uw	3997	38	Nav1.7	nav1.7	NN
cord-001835-0s7ok4uw	3997	39	specificity	specificity	NN
cord-001835-0s7ok4uw	3997	40	and	and	CC
cord-001835-0s7ok4uw	3997	41	minimising	minimise	VBG
cord-001835-0s7ok4uw	3997	42	side	side	JJ
cord-001835-0s7ok4uw	3997	43	effects	effect	NNS
cord-001835-0s7ok4uw	3997	44	.	.	.
cord-001835-0s7ok4uw	3998	1	Maria	Maria	NNP
cord-001835-0s7ok4uw	3998	2	Antonietta	Antonietta	NNP
cord-001835-0s7ok4uw	3998	3	Carillo	Carillo	NNP
cord-001835-0s7ok4uw	3998	4	1	1	CD
cord-001835-0s7ok4uw	3998	5	,	,	,
cord-001835-0s7ok4uw	3998	6	Daniel	Daniel	NNP
cord-001835-0s7ok4uw	3998	7	Varon	Varon	NNP
cord-001835-0s7ok4uw	3998	8	Silva	Silva	NNP
cord-001835-0s7ok4uw	3999	1	1	1	LS
cord-001835-0s7ok4uw	3999	2	1	1	CD
cord-001835-0s7ok4uw	3999	3	Malaria	Malaria	NNP
cord-001835-0s7ok4uw	3999	4	is	be	VBZ
cord-001835-0s7ok4uw	3999	5	one	one	CD
cord-001835-0s7ok4uw	3999	6	of	of	IN
cord-001835-0s7ok4uw	3999	7	the	the	DT
cord-001835-0s7ok4uw	3999	8	most	most	RBS
cord-001835-0s7ok4uw	3999	9	infectious	infectious	JJ
cord-001835-0s7ok4uw	3999	10	diseases	disease	NNS
cord-001835-0s7ok4uw	3999	11	caused	cause	VBN
cord-001835-0s7ok4uw	3999	12	by	by	IN
cord-001835-0s7ok4uw	3999	13	Plasmodium	Plasmodium	NNP
cord-001835-0s7ok4uw	3999	14	species	specie	NNS
cord-001835-0s7ok4uw	3999	15	parasites	parasite	NNS
cord-001835-0s7ok4uw	3999	16	.	.	.
cord-001835-0s7ok4uw	4000	1	The	the	DT
cord-001835-0s7ok4uw	4000	2	merozoite	merozoite	NNP
cord-001835-0s7ok4uw	4000	3	surface	surface	NN
cord-001835-0s7ok4uw	4000	4	protein	protein	NN
cord-001835-0s7ok4uw	4000	5	1	1	CD
cord-001835-0s7ok4uw	4000	6	(	(	-LRB-
cord-001835-0s7ok4uw	4000	7	MSP1	MSP1	NNP
cord-001835-0s7ok4uw	4000	8	)	)	-RRB-
cord-001835-0s7ok4uw	4000	9	is	be	VBZ
cord-001835-0s7ok4uw	4000	10	the	the	DT
cord-001835-0s7ok4uw	4000	11	most	most	RBS
cord-001835-0s7ok4uw	4000	12	abundant	abundant	JJ
cord-001835-0s7ok4uw	4000	13	protein	protein	NN
cord-001835-0s7ok4uw	4000	14	on	on	IN
cord-001835-0s7ok4uw	4000	15	the	the	DT
cord-001835-0s7ok4uw	4000	16	surface	surface	NN
cord-001835-0s7ok4uw	4000	17	of	of	IN
cord-001835-0s7ok4uw	4000	18	the	the	DT
cord-001835-0s7ok4uw	4000	19	Plasmodium	Plasmodium	NNP
cord-001835-0s7ok4uw	4000	20	species	species	NN
cord-001835-0s7ok4uw	4000	21	merozoite	merozoite	JJ
cord-001835-0s7ok4uw	4000	22	stage	stage	NN
cord-001835-0s7ok4uw	4000	23	,	,	,
cord-001835-0s7ok4uw	4000	24	which	which	WDT
cord-001835-0s7ok4uw	4000	25	plays	play	VBZ
cord-001835-0s7ok4uw	4000	26	an	an	DT
cord-001835-0s7ok4uw	4000	27	important	important	JJ
cord-001835-0s7ok4uw	4000	28	role	role	NN
cord-001835-0s7ok4uw	4000	29	during	during	IN
cord-001835-0s7ok4uw	4000	30	the	the	DT
cord-001835-0s7ok4uw	4000	31	erythrocytes	erythrocyte	NNS
cord-001835-0s7ok4uw	4000	32	invasion	invasion	NN
cord-001835-0s7ok4uw	4000	33	process	process	NN
cord-001835-0s7ok4uw	4000	34	[	[	-LRB-
cord-001835-0s7ok4uw	4000	35	1	1	CD
cord-001835-0s7ok4uw	4000	36	]	]	-RRB-
cord-001835-0s7ok4uw	4000	37	.	.	.
cord-001835-0s7ok4uw	4001	1	MSP1	MSP1	NNP
cord-001835-0s7ok4uw	4001	2	is	be	VBZ
cord-001835-0s7ok4uw	4001	3	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	4001	4	as	as	IN
cord-001835-0s7ok4uw	4001	5	a	a	DT
cord-001835-0s7ok4uw	4001	6	200-kDa	200-kda	CD
cord-001835-0s7ok4uw	4001	7	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NN
cord-001835-0s7ok4uw	4001	8	(	(	-LRB-
cord-001835-0s7ok4uw	4001	9	GPI	GPI	NNP
cord-001835-0s7ok4uw	4001	10	)	)	-RRB-
cord-001835-0s7ok4uw	4001	11	anchored	anchor	VBD
cord-001835-0s7ok4uw	4001	12	protein	protein	NN
cord-001835-0s7ok4uw	4001	13	precursor	precursor	NN
cord-001835-0s7ok4uw	4001	14	which	which	WDT
cord-001835-0s7ok4uw	4001	15	is	be	VBZ
cord-001835-0s7ok4uw	4001	16	processed	process	VBN
cord-001835-0s7ok4uw	4001	17	at	at	IN
cord-001835-0s7ok4uw	4001	18	the	the	DT
cord-001835-0s7ok4uw	4001	19	end	end	NN
cord-001835-0s7ok4uw	4001	20	of	of	IN
cord-001835-0s7ok4uw	4001	21	the	the	DT
cord-001835-0s7ok4uw	4001	22	schizogony	schizogony	NN
cord-001835-0s7ok4uw	4001	23	into	into	IN
cord-001835-0s7ok4uw	4001	24	four	four	CD
cord-001835-0s7ok4uw	4001	25	different	different	JJ
cord-001835-0s7ok4uw	4001	26	fragments	fragment	NNS
cord-001835-0s7ok4uw	4001	27	.	.	.
cord-001835-0s7ok4uw	4002	1	The	the	DT
cord-001835-0s7ok4uw	4002	2	primary	primary	JJ
cord-001835-0s7ok4uw	4002	3	processing	processing	NN
cord-001835-0s7ok4uw	4002	4	step	step	NN
cord-001835-0s7ok4uw	4002	5	produces	produce	VBZ
cord-001835-0s7ok4uw	4002	6	a	a	DT
cord-001835-0s7ok4uw	4002	7	complex	complex	NN
cord-001835-0s7ok4uw	4002	8	of	of	IN
cord-001835-0s7ok4uw	4002	9	four	four	CD
cord-001835-0s7ok4uw	4002	10	fragments	fragment	NNS
cord-001835-0s7ok4uw	4002	11	that	that	WDT
cord-001835-0s7ok4uw	4002	12	are	be	VBP
cord-001835-0s7ok4uw	4002	13	present	present	JJ
cord-001835-0s7ok4uw	4002	14	on	on	IN
cord-001835-0s7ok4uw	4002	15	the	the	DT
cord-001835-0s7ok4uw	4002	16	merozoite	merozoite	NNP
cord-001835-0s7ok4uw	4002	17	surface	surface	NN
cord-001835-0s7ok4uw	4002	18	.	.	.
cord-001835-0s7ok4uw	4003	1	The	the	DT
cord-001835-0s7ok4uw	4003	2	secondary	secondary	JJ
cord-001835-0s7ok4uw	4003	3	processing	processing	NN
cord-001835-0s7ok4uw	4003	4	step	step	NN
cord-001835-0s7ok4uw	4003	5	at	at	IN
cord-001835-0s7ok4uw	4003	6	erythrocytes	erythrocyte	VBZ
cord-001835-0s7ok4uw	4003	7	invasion	invasion	NN
cord-001835-0s7ok4uw	4003	8	results	result	NNS
cord-001835-0s7ok4uw	4003	9	in	in	IN
cord-001835-0s7ok4uw	4003	10	the	the	DT
cord-001835-0s7ok4uw	4003	11	detaching	detaching	NN
cord-001835-0s7ok4uw	4003	12	of	of	IN
cord-001835-0s7ok4uw	4003	13	the	the	DT
cord-001835-0s7ok4uw	4003	14	complex	complex	NN
cord-001835-0s7ok4uw	4003	15	from	from	IN
cord-001835-0s7ok4uw	4003	16	the	the	DT
cord-001835-0s7ok4uw	4003	17	surface	surface	NN
cord-001835-0s7ok4uw	4003	18	,	,	,
cord-001835-0s7ok4uw	4003	19	except	except	IN
cord-001835-0s7ok4uw	4003	20	for	for	IN
cord-001835-0s7ok4uw	4003	21	the	the	DT
cord-001835-0s7ok4uw	4003	22	Cterminal	Cterminal	NNP
cord-001835-0s7ok4uw	4003	23	19-kDa	19-kda	CD
cord-001835-0s7ok4uw	4003	24	domain	domain	NN
cord-001835-0s7ok4uw	4003	25	(	(	-LRB-
cord-001835-0s7ok4uw	4003	26	MSP119	MSP119	NNP
cord-001835-0s7ok4uw	4003	27	)	)	-RRB-
cord-001835-0s7ok4uw	4003	28	,	,	,
cord-001835-0s7ok4uw	4003	29	which	which	WDT
cord-001835-0s7ok4uw	4003	30	remains	remain	VBZ
cord-001835-0s7ok4uw	4003	31	anchored	anchor	VBN
cord-001835-0s7ok4uw	4003	32	to	to	IN
cord-001835-0s7ok4uw	4003	33	the	the	DT
cord-001835-0s7ok4uw	4003	34	parasite	parasite	NN
cord-001835-0s7ok4uw	4003	35	surface	surface	NN
cord-001835-0s7ok4uw	4003	36	by	by	IN
cord-001835-0s7ok4uw	4003	37	the	the	DT
cord-001835-0s7ok4uw	4003	38	GPI	GPI	NNP
cord-001835-0s7ok4uw	4003	39	moiety	moiety	NN
cord-001835-0s7ok4uw	4003	40	.	.	.
cord-001835-0s7ok4uw	4004	1	In	in	IN
cord-001835-0s7ok4uw	4004	2	human	human	JJ
cord-001835-0s7ok4uw	4004	3	malarial	malarial	JJ
cord-001835-0s7ok4uw	4004	4	infections	infection	NNS
cord-001835-0s7ok4uw	4004	5	,	,	,
cord-001835-0s7ok4uw	4004	6	the	the	DT
cord-001835-0s7ok4uw	4004	7	GPI	GPI	NNP
cord-001835-0s7ok4uw	4004	8	is	be	VBZ
cord-001835-0s7ok4uw	4004	9	considered	consider	VBN
cord-001835-0s7ok4uw	4004	10	to	to	TO
cord-001835-0s7ok4uw	4004	11	be	be	VB
cord-001835-0s7ok4uw	4004	12	a	a	DT
cord-001835-0s7ok4uw	4004	13	toxin	toxin	NN
cord-001835-0s7ok4uw	4004	14	that	that	WDT
cord-001835-0s7ok4uw	4004	15	causes	cause	VBZ
cord-001835-0s7ok4uw	4004	16	the	the	DT
cord-001835-0s7ok4uw	4004	17	expression	expression	NN
cord-001835-0s7ok4uw	4004	18	of	of	IN
cord-001835-0s7ok4uw	4004	19	various	various	JJ
cord-001835-0s7ok4uw	4004	20	host	host	NN
cord-001835-0s7ok4uw	4004	21	genes	gene	NNS
cord-001835-0s7ok4uw	4004	22	and	and	CC
cord-001835-0s7ok4uw	4004	23	induces	induce	VBZ
cord-001835-0s7ok4uw	4004	24	a	a	DT
cord-001835-0s7ok4uw	4004	25	pro	pro	JJ
cord-001835-0s7ok4uw	4004	26	-	-	JJ
cord-001835-0s7ok4uw	4004	27	inflammatory	inflammatory	JJ
cord-001835-0s7ok4uw	4004	28	immune	immune	JJ
cord-001835-0s7ok4uw	4004	29	response	response	NN
cord-001835-0s7ok4uw	4004	30	,	,	,
cord-001835-0s7ok4uw	4004	31	making	make	VBG
cord-001835-0s7ok4uw	4004	32	it	-PRON-	PRP
cord-001835-0s7ok4uw	4004	33	a	a	DT
cord-001835-0s7ok4uw	4004	34	valuable	valuable	JJ
cord-001835-0s7ok4uw	4004	35	candidate	candidate	NN
cord-001835-0s7ok4uw	4004	36	for	for	IN
cord-001835-0s7ok4uw	4004	37	the	the	DT
cord-001835-0s7ok4uw	4004	38	development	development	NN
cord-001835-0s7ok4uw	4004	39	of	of	IN
cord-001835-0s7ok4uw	4004	40	anti	anti	JJ
cord-001835-0s7ok4uw	4004	41	-	-	JJ
cord-001835-0s7ok4uw	4004	42	malarial	malarial	JJ
cord-001835-0s7ok4uw	4004	43	drugs	drug	NNS
cord-001835-0s7ok4uw	4004	44	.	.	.
cord-001835-0s7ok4uw	4005	1	In	in	IN
cord-001835-0s7ok4uw	4005	2	order	order	NN
cord-001835-0s7ok4uw	4005	3	to	to	TO
cord-001835-0s7ok4uw	4005	4	study	study	VB
cord-001835-0s7ok4uw	4005	5	the	the	DT
cord-001835-0s7ok4uw	4005	6	function	function	NN
cord-001835-0s7ok4uw	4005	7	of	of	IN
cord-001835-0s7ok4uw	4005	8	the	the	DT
cord-001835-0s7ok4uw	4005	9	GPI	GPI	NNP
cord-001835-0s7ok4uw	4005	10	and	and	CC
cord-001835-0s7ok4uw	4005	11	evaluate	evaluate	VB
cord-001835-0s7ok4uw	4005	12	the	the	DT
cord-001835-0s7ok4uw	4005	13	effects	effect	NNS
cord-001835-0s7ok4uw	4005	14	,	,	,
cord-001835-0s7ok4uw	4005	15	MSP119	MSP119	NNP
cord-001835-0s7ok4uw	4005	16	fragment	fragment	NN
cord-001835-0s7ok4uw	4005	17	has	have	VBZ
cord-001835-0s7ok4uw	4005	18	been	be	VBN
cord-001835-0s7ok4uw	4005	19	expressed	express	VBN
cord-001835-0s7ok4uw	4005	20	,	,	,
cord-001835-0s7ok4uw	4005	21	purified	purify	VBN
cord-001835-0s7ok4uw	4005	22	and	and	CC
cord-001835-0s7ok4uw	4005	23	anchored	anchor	VBN
cord-001835-0s7ok4uw	4005	24	to	to	IN
cord-001835-0s7ok4uw	4005	25	the	the	DT
cord-001835-0s7ok4uw	4005	26	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	4005	27	GPI	GPI	NNP
cord-001835-0s7ok4uw	4005	28	molecule	molecule	NN
cord-001835-0s7ok4uw	4005	29	using	use	VBG
cord-001835-0s7ok4uw	4005	30	protein	protein	NN
cord-001835-0s7ok4uw	4005	31	trans	trans	NNP
cord-001835-0s7ok4uw	4005	32	-	-	JJ
cord-001835-0s7ok4uw	4005	33	splicing	splicing	JJ
cord-001835-0s7ok4uw	4005	34	strategy	strategy	NN
cord-001835-0s7ok4uw	4005	35	based	base	VBN
cord-001835-0s7ok4uw	4005	36	on	on	IN
cord-001835-0s7ok4uw	4005	37	the	the	DT
cord-001835-0s7ok4uw	4005	38	split	split	NN
cord-001835-0s7ok4uw	4005	39	intein	intein	NNP
cord-001835-0s7ok4uw	4005	40	method	method	NN
cord-001835-0s7ok4uw	4005	41	[	[	-LRB-
cord-001835-0s7ok4uw	4005	42	2	2	CD
cord-001835-0s7ok4uw	4005	43	]	]	-RRB-
cord-001835-0s7ok4uw	4005	44	.	.	.
cord-001835-0s7ok4uw	4006	1	The	the	DT
cord-001835-0s7ok4uw	4006	2	role	role	NN
cord-001835-0s7ok4uw	4006	3	of	of	IN
cord-001835-0s7ok4uw	4006	4	the	the	DT
cord-001835-0s7ok4uw	4006	5	GPI	GPI	NNP
cord-001835-0s7ok4uw	4006	6	moiety	moiety	NN
cord-001835-0s7ok4uw	4006	7	will	will	MD
cord-001835-0s7ok4uw	4006	8	be	be	VB
cord-001835-0s7ok4uw	4006	9	studied	study	VBN
cord-001835-0s7ok4uw	4006	10	through	through	IN
cord-001835-0s7ok4uw	4006	11	protein	protein	NN
cord-001835-0s7ok4uw	4006	12	folding	fold	VBG
cord-001835-0s7ok4uw	4006	13	experiments	experiment	NNS
cord-001835-0s7ok4uw	4006	14	and	and	CC
cord-001835-0s7ok4uw	4006	15	the	the	DT
cord-001835-0s7ok4uw	4006	16	effect	effect	NN
cord-001835-0s7ok4uw	4006	17	of	of	IN
cord-001835-0s7ok4uw	4006	18	the	the	DT
cord-001835-0s7ok4uw	4006	19	anchored	anchored	JJ
cord-001835-0s7ok4uw	4006	20	protein	protein	NN
cord-001835-0s7ok4uw	4006	21	will	will	MD
cord-001835-0s7ok4uw	4006	22	be	be	VB
cord-001835-0s7ok4uw	4006	23	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	4006	24	in	in	IN
cord-001835-0s7ok4uw	4006	25	vitro	vitro	FW
cord-001835-0s7ok4uw	4006	26	in	in	IN
cord-001835-0s7ok4uw	4006	27	order	order	NN
cord-001835-0s7ok4uw	4006	28	to	to	TO
cord-001835-0s7ok4uw	4006	29	understand	understand	VB
cord-001835-0s7ok4uw	4006	30	the	the	DT
cord-001835-0s7ok4uw	4006	31	function	function	NN
cord-001835-0s7ok4uw	4006	32	of	of	IN
cord-001835-0s7ok4uw	4006	33	the	the	DT
cord-001835-0s7ok4uw	4006	34	GPIs	gpi	NNS
cord-001835-0s7ok4uw	4006	35	.	.	.
cord-001835-0s7ok4uw	4007	1	Assessment	assessment	NN
cord-001835-0s7ok4uw	4007	2	of	of	IN
cord-001835-0s7ok4uw	4007	3	UCH	UCH	NNP
cord-001835-0s7ok4uw	4007	4	-	-	HYPH
cord-001835-0s7ok4uw	4007	5	L3	L3	NNP
cord-001835-0s7ok4uw	4007	6	Substrate	Substrate	NNP
cord-001835-0s7ok4uw	4007	7	Selectivity	Selectivity	NNP
cord-001835-0s7ok4uw	4007	8	using	use	VBG
cord-001835-0s7ok4uw	4007	9	Engineered	Engineered	NNP
cord-001835-0s7ok4uw	4007	10	Ubiquitin	Ubiquitin	NNP
cord-001835-0s7ok4uw	4007	11	Fusions	Fusions	NNPS
cord-001835-0s7ok4uw	4007	12	with	with	IN
cord-001835-0s7ok4uw	4007	13	Varying	Varying	NNP
cord-001835-0s7ok4uw	4007	14	Linker	Linker	NNP
cord-001835-0s7ok4uw	4007	15	Lengths	Lengths	NNP
cord-001835-0s7ok4uw	4007	16	Peter	Peter	NNP
cord-001835-0s7ok4uw	4007	17	Suon	Suon	NNP
cord-001835-0s7ok4uw	4007	18	,	,	,
cord-001835-0s7ok4uw	4007	19	Mario	Mario	NNP
cord-001835-0s7ok4uw	4007	20	Navarro	Navarro	NNP
cord-001835-0s7ok4uw	4007	21	,	,	,
cord-001835-0s7ok4uw	4007	22	John	John	NNP
cord-001835-0s7ok4uw	4007	23	Love	Love	NNP
cord-001835-0s7ok4uw	4007	24	1	1	CD
cord-001835-0s7ok4uw	4007	25	San	San	NNP
cord-001835-0s7ok4uw	4007	26	Diego	Diego	NNP
cord-001835-0s7ok4uw	4007	27	State	State	NNP
cord-001835-0s7ok4uw	4007	28	University	University	NNP
cord-001835-0s7ok4uw	4007	29	,	,	,
cord-001835-0s7ok4uw	4007	30	2	2	CD
cord-001835-0s7ok4uw	4007	31	San	San	NNP
cord-001835-0s7ok4uw	4007	32	Diego	Diego	NNP
cord-001835-0s7ok4uw	4007	33	State	State	NNP
cord-001835-0s7ok4uw	4007	34	University	University	NNP
cord-001835-0s7ok4uw	4007	35	,	,	,
cord-001835-0s7ok4uw	4007	36	3	3	CD
cord-001835-0s7ok4uw	4007	37	 	 	_SP
cord-001835-0s7ok4uw	4007	38	Assessment	Assessment	NNP
cord-001835-0s7ok4uw	4007	39	of	of	IN
cord-001835-0s7ok4uw	4007	40	UCH	UCH	NNP
cord-001835-0s7ok4uw	4007	41	-	-	HYPH
cord-001835-0s7ok4uw	4007	42	L3	L3	NNP
cord-001835-0s7ok4uw	4007	43	Substrate	Substrate	NNP
cord-001835-0s7ok4uw	4007	44	Selectivity	Selectivity	NNP
cord-001835-0s7ok4uw	4007	45	using	use	VBG
cord-001835-0s7ok4uw	4007	46	Engineered	Engineered	NNP
cord-001835-0s7ok4uw	4007	47	Ubiquitin	Ubiquitin	NNP
cord-001835-0s7ok4uw	4007	48	Fusions	Fusions	NNPS
cord-001835-0s7ok4uw	4007	49	with	with	IN
cord-001835-0s7ok4uw	4007	50	Varying	Varying	NNP
cord-001835-0s7ok4uw	4007	51	Linker	Linker	NNP
cord-001835-0s7ok4uw	4007	52	Lengths	Lengths	NNP
cord-001835-0s7ok4uw	4007	53	Peter	Peter	NNP
cord-001835-0s7ok4uw	4007	54	Suon	Suon	NNP
cord-001835-0s7ok4uw	4007	55	,	,	,
cord-001835-0s7ok4uw	4007	56	Mario	Mario	NNP
cord-001835-0s7ok4uw	4007	57	Navarro	Navarro	NNP
cord-001835-0s7ok4uw	4007	58	,	,	,
cord-001835-0s7ok4uw	4007	59	and	and	CC
cord-001835-0s7ok4uw	4007	60	John	John	NNP
cord-001835-0s7ok4uw	4007	61	J.	J.	NNP
cord-001835-0s7ok4uw	4007	62	Love	Love	NNP
cord-001835-0s7ok4uw	4007	63	San	San	NNP
cord-001835-0s7ok4uw	4007	64	Diego	Diego	NNP
cord-001835-0s7ok4uw	4007	65	State	State	NNP
cord-001835-0s7ok4uw	4007	66	University	University	NNP
cord-001835-0s7ok4uw	4008	1	The	the	DT
cord-001835-0s7ok4uw	4008	2	Ubiquitin	Ubiquitin	NNP
cord-001835-0s7ok4uw	4008	3	Proteasome	Proteasome	NNP
cord-001835-0s7ok4uw	4008	4	System	System	NNP
cord-001835-0s7ok4uw	4008	5	(	(	-LRB-
cord-001835-0s7ok4uw	4008	6	UPS	UPS	NNP
cord-001835-0s7ok4uw	4008	7	)	)	-RRB-
cord-001835-0s7ok4uw	4008	8	is	be	VBZ
cord-001835-0s7ok4uw	4008	9	a	a	DT
cord-001835-0s7ok4uw	4008	10	complex	complex	JJ
cord-001835-0s7ok4uw	4008	11	system	system	NN
cord-001835-0s7ok4uw	4008	12	composed	compose	VBN
cord-001835-0s7ok4uw	4008	13	of	of	IN
cord-001835-0s7ok4uw	4008	14	multiple	multiple	JJ
cord-001835-0s7ok4uw	4008	15	structural	structural	JJ
cord-001835-0s7ok4uw	4008	16	and	and	CC
cord-001835-0s7ok4uw	4008	17	functional	functional	JJ
cord-001835-0s7ok4uw	4008	18	elements	element	NNS
cord-001835-0s7ok4uw	4008	19	that	that	WDT
cord-001835-0s7ok4uw	4008	20	play	play	VBP
cord-001835-0s7ok4uw	4008	21	key	key	JJ
cord-001835-0s7ok4uw	4008	22	roles	role	NNS
cord-001835-0s7ok4uw	4008	23	in	in	IN
cord-001835-0s7ok4uw	4008	24	cellular	cellular	JJ
cord-001835-0s7ok4uw	4008	25	processes	process	NNS
cord-001835-0s7ok4uw	4008	26	such	such	JJ
cord-001835-0s7ok4uw	4008	27	as	as	IN
cord-001835-0s7ok4uw	4008	28	signal	signal	NN
cord-001835-0s7ok4uw	4008	29	transduction	transduction	NN
cord-001835-0s7ok4uw	4008	30	,	,	,
cord-001835-0s7ok4uw	4008	31	cell	cell	NN
cord-001835-0s7ok4uw	4008	32	cycle	cycle	NN
cord-001835-0s7ok4uw	4008	33	regulation	regulation	NN
cord-001835-0s7ok4uw	4008	34	,	,	,
cord-001835-0s7ok4uw	4008	35	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	4008	36	,	,	,
cord-001835-0s7ok4uw	4008	37	and	and	CC
cord-001835-0s7ok4uw	4008	38	protein	protein	NN
cord-001835-0s7ok4uw	4008	39	degradation	degradation	NN
cord-001835-0s7ok4uw	4008	40	.	.	.
cord-001835-0s7ok4uw	4009	1	Proteins	protein	NNS
cord-001835-0s7ok4uw	4009	2	destined	destine	VBN
cord-001835-0s7ok4uw	4009	3	for	for	IN
cord-001835-0s7ok4uw	4009	4	degradation	degradation	NN
cord-001835-0s7ok4uw	4009	5	are	be	VBP
cord-001835-0s7ok4uw	4009	6	first	first	RB
cord-001835-0s7ok4uw	4009	7	tagged	tag	VBN
cord-001835-0s7ok4uw	4009	8	with	with	IN
cord-001835-0s7ok4uw	4009	9	the	the	DT
cord-001835-0s7ok4uw	4009	10	protein	protein	NN
cord-001835-0s7ok4uw	4009	11	,	,	,
cord-001835-0s7ok4uw	4009	12	ubiquitin	ubiquitin	NNP
cord-001835-0s7ok4uw	4009	13	,	,	,
cord-001835-0s7ok4uw	4009	14	which	which	WDT
cord-001835-0s7ok4uw	4009	15	is	be	VBZ
cord-001835-0s7ok4uw	4009	16	covalently	covalently	RB
cord-001835-0s7ok4uw	4009	17	attached	attach	VBN
cord-001835-0s7ok4uw	4009	18	to	to	IN
cord-001835-0s7ok4uw	4009	19	internal	internal	JJ
cord-001835-0s7ok4uw	4009	20	lysine	lysine	NN
cord-001835-0s7ok4uw	4009	21	residues	residue	NNS
cord-001835-0s7ok4uw	4009	22	.	.	.
cord-001835-0s7ok4uw	4010	1	Once	once	IN
cord-001835-0s7ok4uw	4010	2	the	the	DT
cord-001835-0s7ok4uw	4010	3	target	target	NN
cord-001835-0s7ok4uw	4010	4	has	have	VBZ
cord-001835-0s7ok4uw	4010	5	be	be	VB
cord-001835-0s7ok4uw	4010	6	degraded	degrade	VBN
cord-001835-0s7ok4uw	4010	7	by	by	IN
cord-001835-0s7ok4uw	4010	8	the	the	DT
cord-001835-0s7ok4uw	4010	9	proteasome	proteasome	NN
cord-001835-0s7ok4uw	4010	10	;	;	:
cord-001835-0s7ok4uw	4010	11	the	the	DT
cord-001835-0s7ok4uw	4010	12	enzyme	enzyme	NN
cord-001835-0s7ok4uw	4010	13	Ubiquitin	Ubiquitin	NNP
cord-001835-0s7ok4uw	4010	14	Carboxy	Carboxy	NNP
cord-001835-0s7ok4uw	4010	15	Hydrolase	Hydrolase	NNP
cord-001835-0s7ok4uw	4010	16	L3	L3	NNP
cord-001835-0s7ok4uw	4010	17	(	(	-LRB-
cord-001835-0s7ok4uw	4010	18	UCH	UCH	NNP
cord-001835-0s7ok4uw	4010	19	-	-	HYPH
cord-001835-0s7ok4uw	4010	20	L3	L3	NNP
cord-001835-0s7ok4uw	4010	21	)	)	-RRB-
cord-001835-0s7ok4uw	4010	22	is	be	VBZ
cord-001835-0s7ok4uw	4010	23	believed	believe	VBN
cord-001835-0s7ok4uw	4010	24	to	to	TO
cord-001835-0s7ok4uw	4010	25	prepare	prepare	VB
cord-001835-0s7ok4uw	4010	26	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4010	27	for	for	IN
cord-001835-0s7ok4uw	4010	28	additional	additional	JJ
cord-001835-0s7ok4uw	4010	29	rounds	round	NNS
cord-001835-0s7ok4uw	4010	30	of	of	IN
cord-001835-0s7ok4uw	4010	31	ubiquitination	ubiquitination	NN
cord-001835-0s7ok4uw	4010	32	by	by	IN
cord-001835-0s7ok4uw	4010	33	cleaving	cleave	VBG
cord-001835-0s7ok4uw	4010	34	small	small	JJ
cord-001835-0s7ok4uw	4010	35	peptides	peptide	NNS
cord-001835-0s7ok4uw	4010	36	and	and	CC
cord-001835-0s7ok4uw	4010	37	chemical	chemical	NN
cord-001835-0s7ok4uw	4010	38	adducts	adduct	NNS
cord-001835-0s7ok4uw	4010	39	from	from	IN
cord-001835-0s7ok4uw	4010	40	the	the	DT
cord-001835-0s7ok4uw	4010	41	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4010	42	C	c	NN
cord-001835-0s7ok4uw	4010	43	-	-	HYPH
cord-001835-0s7ok4uw	4010	44	terminus	terminus	NN
cord-001835-0s7ok4uw	4010	45	.	.	.
cord-001835-0s7ok4uw	4011	1	Previously	previously	RB
cord-001835-0s7ok4uw	4011	2	in	in	IN
cord-001835-0s7ok4uw	4011	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4011	4	laboratory	laboratory	NN
cord-001835-0s7ok4uw	4011	5	,	,	,
cord-001835-0s7ok4uw	4011	6	protein	protein	NN
cord-001835-0s7ok4uw	4011	7	substrates	substrate	NNS
cord-001835-0s7ok4uw	4011	8	of	of	IN
cord-001835-0s7ok4uw	4011	9	UCH	UCH	NNP
cord-001835-0s7ok4uw	4011	10	-	-	HYPH
cord-001835-0s7ok4uw	4011	11	L3	L3	NNP
cord-001835-0s7ok4uw	4011	12	were	be	VBD
cord-001835-0s7ok4uw	4011	13	engineered	engineer	VBN
cord-001835-0s7ok4uw	4011	14	and	and	CC
cord-001835-0s7ok4uw	4011	15	used	use	VBN
cord-001835-0s7ok4uw	4011	16	to	to	TO
cord-001835-0s7ok4uw	4011	17	characterize	characterize	VB
cord-001835-0s7ok4uw	4011	18	UCH	UCH	NNP
cord-001835-0s7ok4uw	4011	19	-	-	HYPH
cord-001835-0s7ok4uw	4011	20	L3	L3	NNP
cord-001835-0s7ok4uw	4011	21	substrate	substrate	NN
cord-001835-0s7ok4uw	4011	22	selectivity	selectivity	NN
cord-001835-0s7ok4uw	4011	23	.	.	.
cord-001835-0s7ok4uw	4012	1	The	the	DT
cord-001835-0s7ok4uw	4012	2	engineered	engineer	VBN
cord-001835-0s7ok4uw	4012	3	substrates	substrate	NNS
cord-001835-0s7ok4uw	4012	4	consisted	consist	VBD
cord-001835-0s7ok4uw	4012	5	of	of	IN
cord-001835-0s7ok4uw	4012	6	N	n	CD
cord-001835-0s7ok4uw	4012	7	-	-	HYPH
cord-001835-0s7ok4uw	4012	8	terminal	terminal	NN
cord-001835-0s7ok4uw	4012	9	monoubiquitinated	monoubiquitinated	JJ
cord-001835-0s7ok4uw	4012	10	test	test	NN
cord-001835-0s7ok4uw	4012	11	variants	variant	NNS
cord-001835-0s7ok4uw	4012	12	derived	derive	VBN
cord-001835-0s7ok4uw	4012	13	from	from	IN
cord-001835-0s7ok4uw	4012	14	Streptococcal	Streptococcal	NNP
cord-001835-0s7ok4uw	4012	15	protein	protein	NN
cord-001835-0s7ok4uw	4012	16	G	g	NN
cord-001835-0s7ok4uw	4012	17	(	(	-LRB-
cord-001835-0s7ok4uw	4012	18	protein	protein	NN
cord-001835-0s7ok4uw	4012	19	Gb1	gb1	CD
cord-001835-0s7ok4uw	4012	20	)	)	-RRB-
cord-001835-0s7ok4uw	4012	21	and	and	CC
cord-001835-0s7ok4uw	4012	22	Staphylococcal	staphylococcal	JJ
cord-001835-0s7ok4uw	4012	23	protein	protein	NN
cord-001835-0s7ok4uw	4012	24	A	a	NN
cord-001835-0s7ok4uw	4012	25	(	(	-LRB-
cord-001835-0s7ok4uw	4012	26	SpAB	SpAB	NNP
cord-001835-0s7ok4uw	4012	27	)	)	-RRB-
cord-001835-0s7ok4uw	4012	28	.	.	.
cord-001835-0s7ok4uw	4013	1	The	the	DT
cord-001835-0s7ok4uw	4013	2	thermal	thermal	JJ
cord-001835-0s7ok4uw	4013	3	denaturation	denaturation	NN
cord-001835-0s7ok4uw	4013	4	temperatures	temperature	NNS
cord-001835-0s7ok4uw	4013	5	(	(	-LRB-
cord-001835-0s7ok4uw	4013	6	Tm	Tm	NNP
cord-001835-0s7ok4uw	4013	7	)	)	-RRB-
cord-001835-0s7ok4uw	4013	8	of	of	IN
cord-001835-0s7ok4uw	4013	9	the	the	DT
cord-001835-0s7ok4uw	4013	10	fusion	fusion	NN
cord-001835-0s7ok4uw	4013	11	proteins	protein	NNS
cord-001835-0s7ok4uw	4013	12	were	be	VBD
cord-001835-0s7ok4uw	4013	13	measured	measure	VBN
cord-001835-0s7ok4uw	4013	14	using	use	VBG
cord-001835-0s7ok4uw	4013	15	circular	circular	JJ
cord-001835-0s7ok4uw	4013	16	dichroism	dichroism	NN
cord-001835-0s7ok4uw	4013	17	and	and	CC
cord-001835-0s7ok4uw	4013	18	span	span	VB
cord-001835-0s7ok4uw	4013	19	a	a	DT
cord-001835-0s7ok4uw	4013	20	range	range	NN
cord-001835-0s7ok4uw	4013	21	of	of	IN
cord-001835-0s7ok4uw	4013	22	over	over	IN
cord-001835-0s7ok4uw	4013	23	608C.	608c.	NN
cord-001835-0s7ok4uw	4013	24	More	more	RBR
cord-001835-0s7ok4uw	4013	25	importantly	importantly	RB
cord-001835-0s7ok4uw	4013	26	,	,	,
cord-001835-0s7ok4uw	4013	27	the	the	DT
cord-001835-0s7ok4uw	4013	28	rate	rate	NN
cord-001835-0s7ok4uw	4013	29	of	of	IN
cord-001835-0s7ok4uw	4013	30	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	4013	31	for	for	IN
cord-001835-0s7ok4uw	4013	32	the	the	DT
cord-001835-0s7ok4uw	4013	33	fusion	fusion	NN
cord-001835-0s7ok4uw	4013	34	proteins	protein	NNS
cord-001835-0s7ok4uw	4013	35	is	be	VBZ
cord-001835-0s7ok4uw	4013	36	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	4013	37	to	to	TO
cord-001835-0s7ok4uw	4013	38	be	be	VB
cord-001835-0s7ok4uw	4013	39	directly	directly	RB
cord-001835-0s7ok4uw	4013	40	correlated	correlate	VBN
cord-001835-0s7ok4uw	4013	41	to	to	IN
cord-001835-0s7ok4uw	4013	42	the	the	DT
cord-001835-0s7ok4uw	4013	43	Tm	Tm	NNP
cord-001835-0s7ok4uw	4013	44	of	of	IN
cord-001835-0s7ok4uw	4013	45	the	the	DT
cord-001835-0s7ok4uw	4013	46	test	test	NN
cord-001835-0s7ok4uw	4013	47	variant	variant	NN
cord-001835-0s7ok4uw	4013	48	fused	fuse	VBN
cord-001835-0s7ok4uw	4013	49	to	to	IN
cord-001835-0s7ok4uw	4013	50	the	the	DT
cord-001835-0s7ok4uw	4013	51	C	c	NN
cord-001835-0s7ok4uw	4013	52	-	-	HYPH
cord-001835-0s7ok4uw	4013	53	terminus	terminus	NN
cord-001835-0s7ok4uw	4013	54	of	of	IN
cord-001835-0s7ok4uw	4013	55	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4013	56	.	.	.
cord-001835-0s7ok4uw	4014	1	Previously	previously	RB
cord-001835-0s7ok4uw	4014	2	,	,	,
cord-001835-0s7ok4uw	4014	3	the	the	DT
cord-001835-0s7ok4uw	4014	4	engineered	engineer	VBN
cord-001835-0s7ok4uw	4014	5	substrates	substrate	NNS
cord-001835-0s7ok4uw	4014	6	were	be	VBD
cord-001835-0s7ok4uw	4014	7	designed	design	VBN
cord-001835-0s7ok4uw	4014	8	to	to	TO
cord-001835-0s7ok4uw	4014	9	emulate	emulate	VB
cord-001835-0s7ok4uw	4014	10	natural	natural	JJ
cord-001835-0s7ok4uw	4014	11	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4014	12	fusions	fusion	NNS
cord-001835-0s7ok4uw	4014	13	and	and	CC
cord-001835-0s7ok4uw	4014	14	thus	thus	RB
cord-001835-0s7ok4uw	4014	15	did	do	VBD
cord-001835-0s7ok4uw	4014	16	not	not	RB
cord-001835-0s7ok4uw	4014	17	contain	contain	VB
cord-001835-0s7ok4uw	4014	18	any	any	DT
cord-001835-0s7ok4uw	4014	19	'	'	``
cord-001835-0s7ok4uw	4014	20	linker	linker	NN
cord-001835-0s7ok4uw	4014	21	'	'	''
cord-001835-0s7ok4uw	4014	22	residues	residue	NNS
cord-001835-0s7ok4uw	4014	23	between	between	IN
cord-001835-0s7ok4uw	4014	24	the	the	DT
cord-001835-0s7ok4uw	4014	25	C	c	NN
cord-001835-0s7ok4uw	4014	26	-	-	HYPH
cord-001835-0s7ok4uw	4014	27	terminus	terminus	NN
cord-001835-0s7ok4uw	4014	28	of	of	IN
cord-001835-0s7ok4uw	4014	29	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4014	30	and	and	CC
cord-001835-0s7ok4uw	4014	31	the	the	DT
cord-001835-0s7ok4uw	4014	32	N	n	NN
cord-001835-0s7ok4uw	4014	33	-	-	HYPH
cord-001835-0s7ok4uw	4014	34	terminus	terminus	NN
cord-001835-0s7ok4uw	4014	35	of	of	IN
cord-001835-0s7ok4uw	4014	36	the	the	DT
cord-001835-0s7ok4uw	4014	37	test	test	NN
cord-001835-0s7ok4uw	4014	38	protein	protein	NN
cord-001835-0s7ok4uw	4014	39	.	.	.
cord-001835-0s7ok4uw	4015	1	To	to	TO
cord-001835-0s7ok4uw	4015	2	explore	explore	VB
cord-001835-0s7ok4uw	4015	3	the	the	DT
cord-001835-0s7ok4uw	4015	4	effects	effect	NNS
cord-001835-0s7ok4uw	4015	5	of	of	IN
cord-001835-0s7ok4uw	4015	6	linker	linker	NN
cord-001835-0s7ok4uw	4015	7	length	length	NN
cord-001835-0s7ok4uw	4015	8	on	on	IN
cord-001835-0s7ok4uw	4015	9	UCH	UCH	NNP
cord-001835-0s7ok4uw	4015	10	-	-	HYPH
cord-001835-0s7ok4uw	4015	11	L3	L3	NNP
cord-001835-0s7ok4uw	4015	12	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	4015	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	4015	14	are	be	VBP
cord-001835-0s7ok4uw	4015	15	engineering	engineer	VBG
cord-001835-0s7ok4uw	4015	16	new	new	JJ
cord-001835-0s7ok4uw	4015	17	UCH	UCH	NNP
cord-001835-0s7ok4uw	4015	18	-	-	HYPH
cord-001835-0s7ok4uw	4015	19	L3	L3	NNP
cord-001835-0s7ok4uw	4015	20	substrates	substrate	NNS
cord-001835-0s7ok4uw	4015	21	that	that	WDT
cord-001835-0s7ok4uw	4015	22	contain	contain	VBP
cord-001835-0s7ok4uw	4015	23	an	an	DT
cord-001835-0s7ok4uw	4015	24	unstructured	unstructured	JJ
cord-001835-0s7ok4uw	4015	25	12	12	CD
cord-001835-0s7ok4uw	4015	26	amino	amino	NN
cord-001835-0s7ok4uw	4015	27	acid	acid	NN
cord-001835-0s7ok4uw	4015	28	linker	linker	NN
cord-001835-0s7ok4uw	4015	29	between	between	IN
cord-001835-0s7ok4uw	4015	30	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4015	31	and	and	CC
cord-001835-0s7ok4uw	4015	32	the	the	DT
cord-001835-0s7ok4uw	4015	33	test	test	NN
cord-001835-0s7ok4uw	4015	34	protein	protein	NN
cord-001835-0s7ok4uw	4015	35	.	.	.
cord-001835-0s7ok4uw	4016	1	To	to	TO
cord-001835-0s7ok4uw	4016	2	further	further	RB
cord-001835-0s7ok4uw	4016	3	explore	explore	VB
cord-001835-0s7ok4uw	4016	4	the	the	DT
cord-001835-0s7ok4uw	4016	5	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	4016	6	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4016	7	of	of	IN
cord-001835-0s7ok4uw	4016	8	UCH	UCH	NNP
cord-001835-0s7ok4uw	4016	9	-	-	HYPH
cord-001835-0s7ok4uw	4016	10	L3	L3	NNP
cord-001835-0s7ok4uw	4016	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	4016	12	will	will	MD
cord-001835-0s7ok4uw	4016	13	revisit	revisit	VB
cord-001835-0s7ok4uw	4016	14	diubiquitin	diubiquitin	NNS
cord-001835-0s7ok4uw	4016	15	(	(	-LRB-
cord-001835-0s7ok4uw	4016	16	Ub	Ub	NNP
cord-001835-0s7ok4uw	4016	17	-	-	HYPH
cord-001835-0s7ok4uw	4016	18	Ub	Ub	NNP
cord-001835-0s7ok4uw	4016	19	)	)	-RRB-
cord-001835-0s7ok4uw	4016	20	,	,	,
cord-001835-0s7ok4uw	4016	21	which	which	WDT
cord-001835-0s7ok4uw	4016	22	is	be	VBZ
cord-001835-0s7ok4uw	4016	23	not	not	RB
cord-001835-0s7ok4uw	4016	24	hydrolyzed	hydrolyze	VBN
cord-001835-0s7ok4uw	4016	25	by	by	IN
cord-001835-0s7ok4uw	4016	26	UCH	UCH	NNP
cord-001835-0s7ok4uw	4016	27	-	-	HYPH
cord-001835-0s7ok4uw	4016	28	L3	L3	NNP
cord-001835-0s7ok4uw	4016	29	,	,	,
cord-001835-0s7ok4uw	4016	30	and	and	CC
cord-001835-0s7ok4uw	4016	31	will	will	MD
cord-001835-0s7ok4uw	4016	32	make	make	VB
cord-001835-0s7ok4uw	4016	33	mutations	mutation	NNS
cord-001835-0s7ok4uw	4016	34	in	in	IN
cord-001835-0s7ok4uw	4016	35	the	the	DT
cord-001835-0s7ok4uw	4016	36	hopes	hope	NNS
cord-001835-0s7ok4uw	4016	37	of	of	IN
cord-001835-0s7ok4uw	4016	38	generating	generate	VBG
cord-001835-0s7ok4uw	4016	39	a	a	DT
cord-001835-0s7ok4uw	4016	40	hydrolysable	hydrolysable	JJ
cord-001835-0s7ok4uw	4016	41	substrate	substrate	NN
cord-001835-0s7ok4uw	4016	42	.	.	.
cord-001835-0s7ok4uw	4017	1	Using	use	VBG
cord-001835-0s7ok4uw	4017	2	rational	rational	JJ
cord-001835-0s7ok4uw	4017	3	design	design	NN
cord-001835-0s7ok4uw	4017	4	,	,	,
cord-001835-0s7ok4uw	4017	5	the	the	DT
cord-001835-0s7ok4uw	4017	6	new	new	JJ
cord-001835-0s7ok4uw	4017	7	variants	variant	NNS
cord-001835-0s7ok4uw	4017	8	will	will	MD
cord-001835-0s7ok4uw	4017	9	be	be	VB
cord-001835-0s7ok4uw	4017	10	engineered	engineer	VBN
cord-001835-0s7ok4uw	4017	11	to	to	TO
cord-001835-0s7ok4uw	4017	12	destabilize	destabilize	VB
cord-001835-0s7ok4uw	4017	13	the	the	DT
cord-001835-0s7ok4uw	4017	14	C	c	NN
cord-001835-0s7ok4uw	4017	15	-	-	HYPH
cord-001835-0s7ok4uw	4017	16	terminal	terminal	NN
cord-001835-0s7ok4uw	4017	17	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4017	18	to	to	TO
cord-001835-0s7ok4uw	4017	19	determine	determine	VB
cord-001835-0s7ok4uw	4017	20	if	if	IN
cord-001835-0s7ok4uw	4017	21	this	this	DT
cord-001835-0s7ok4uw	4017	22	results	result	NNS
cord-001835-0s7ok4uw	4017	23	in	in	IN
cord-001835-0s7ok4uw	4017	24	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	4017	25	of	of	IN
cord-001835-0s7ok4uw	4017	26	the	the	DT
cord-001835-0s7ok4uw	4017	27	new	new	JJ
cord-001835-0s7ok4uw	4017	28	Ub	Ub	NNP
cord-001835-0s7ok4uw	4017	29	-	-	HYPH
cord-001835-0s7ok4uw	4017	30	Ub	Ub	NNP
cord-001835-0s7ok4uw	4017	31	construct	construct	NN
cord-001835-0s7ok4uw	4017	32	.	.	.
cord-001835-0s7ok4uw	4018	1	The	the	DT
cord-001835-0s7ok4uw	4018	2	thermal	thermal	JJ
cord-001835-0s7ok4uw	4018	3	stability	stability	NN
cord-001835-0s7ok4uw	4018	4	of	of	IN
cord-001835-0s7ok4uw	4018	5	these	these	DT
cord-001835-0s7ok4uw	4018	6	new	new	JJ
cord-001835-0s7ok4uw	4018	7	fusion	fusion	NN
cord-001835-0s7ok4uw	4018	8	protein	protein	NN
cord-001835-0s7ok4uw	4018	9	substrates	substrate	NNS
cord-001835-0s7ok4uw	4018	10	will	will	MD
cord-001835-0s7ok4uw	4018	11	be	be	VB
cord-001835-0s7ok4uw	4018	12	measured	measure	VBN
cord-001835-0s7ok4uw	4018	13	using	use	VBG
cord-001835-0s7ok4uw	4018	14	circular	circular	JJ
cord-001835-0s7ok4uw	4018	15	dichroism	dichroism	NN
cord-001835-0s7ok4uw	4018	16	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	4018	17	(	(	-LRB-
cord-001835-0s7ok4uw	4018	18	CD	CD	NNP
cord-001835-0s7ok4uw	4018	19	)	)	-RRB-
cord-001835-0s7ok4uw	4018	20	and	and	CC
cord-001835-0s7ok4uw	4018	21	UCH	UCH	NNP
cord-001835-0s7ok4uw	4018	22	-	-	HYPH
cord-001835-0s7ok4uw	4018	23	L3	L3	NNP
cord-001835-0s7ok4uw	4018	24	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	4018	25	rates	rate	NNS
cord-001835-0s7ok4uw	4018	26	will	will	MD
cord-001835-0s7ok4uw	4018	27	be	be	VB
cord-001835-0s7ok4uw	4018	28	characterized	characterize	VBN
cord-001835-0s7ok4uw	4018	29	using	use	VBG
cord-001835-0s7ok4uw	4018	30	existing	exist	VBG
cord-001835-0s7ok4uw	4018	31	assays	assay	NNS
cord-001835-0s7ok4uw	4018	32	.	.	.
cord-001835-0s7ok4uw	4019	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4019	2	goal	goal	NN
cord-001835-0s7ok4uw	4019	3	is	be	VBZ
cord-001835-0s7ok4uw	4019	4	to	to	TO
cord-001835-0s7ok4uw	4019	5	continue	continue	VB
cord-001835-0s7ok4uw	4019	6	the	the	DT
cord-001835-0s7ok4uw	4019	7	use	use	NN
cord-001835-0s7ok4uw	4019	8	of	of	IN
cord-001835-0s7ok4uw	4019	9	engineered	engineer	VBN
cord-001835-0s7ok4uw	4019	10	substrates	substrate	NNS
cord-001835-0s7ok4uw	4019	11	to	to	TO
cord-001835-0s7ok4uw	4019	12	further	further	RB
cord-001835-0s7ok4uw	4019	13	explore	explore	VB
cord-001835-0s7ok4uw	4019	14	the	the	DT
cord-001835-0s7ok4uw	4019	15	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	4019	16	properties	property	NNS
cord-001835-0s7ok4uw	4019	17	of	of	IN
cord-001835-0s7ok4uw	4019	18	UCH	UCH	NNP
cord-001835-0s7ok4uw	4019	19	-	-	HYPH
cord-001835-0s7ok4uw	4019	20	L3	L3	NNP
cord-001835-0s7ok4uw	4019	21	activity	activity	NN
cord-001835-0s7ok4uw	4019	22	and	and	CC
cord-001835-0s7ok4uw	4019	23	the	the	DT
cord-001835-0s7ok4uw	4019	24	potential	potential	JJ
cord-001835-0s7ok4uw	4019	25	role	role	NN
cord-001835-0s7ok4uw	4019	26	in	in	IN
cord-001835-0s7ok4uw	4019	27	protein	protein	NN
cord-001835-0s7ok4uw	4019	28	trafficking	trafficking	NN
cord-001835-0s7ok4uw	4019	29	and	and	CC
cord-001835-0s7ok4uw	4019	30	degradation	degradation	NN
cord-001835-0s7ok4uw	4019	31	within	within	IN
cord-001835-0s7ok4uw	4019	32	living	living	NN
cord-001835-0s7ok4uw	4019	33	cells	cell	NNS
cord-001835-0s7ok4uw	4019	34	.	.	.
cord-001835-0s7ok4uw	4019	35	 	 	_SP
cord-001835-0s7ok4uw	4020	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4020	2	present	present	VBP
cord-001835-0s7ok4uw	4020	3	a	a	DT
cord-001835-0s7ok4uw	4020	4	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	4020	5	study	study	NN
cord-001835-0s7ok4uw	4020	6	of	of	IN
cord-001835-0s7ok4uw	4020	7	a	a	DT
cord-001835-0s7ok4uw	4020	8	suite	suite	NN
cord-001835-0s7ok4uw	4020	9	of	of	IN
cord-001835-0s7ok4uw	4020	10	helical	helical	JJ
cord-001835-0s7ok4uw	4020	11	proteins	protein	NNS
cord-001835-0s7ok4uw	4020	12	that	that	WDT
cord-001835-0s7ok4uw	4020	13	have	have	VBP
cord-001835-0s7ok4uw	4020	14	been	be	VBN
cord-001835-0s7ok4uw	4020	15	modified	modify	VBN
cord-001835-0s7ok4uw	4020	16	to	to	TO
cord-001835-0s7ok4uw	4020	17	contain	contain	VB
cord-001835-0s7ok4uw	4020	18	12and	12and	JJ
cord-001835-0s7ok4uw	4020	19	17-amino	17-amino	CD
cord-001835-0s7ok4uw	4020	20	acid	acid	JJ
cord-001835-0s7ok4uw	4020	21	additions	addition	NNS
cord-001835-0s7ok4uw	4020	22	on	on	IN
cord-001835-0s7ok4uw	4020	23	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4020	24	termini	terminus	NNS
cord-001835-0s7ok4uw	4020	25	that	that	WDT
cord-001835-0s7ok4uw	4020	26	impart	impart	VBP
cord-001835-0s7ok4uw	4020	27	increased	increase	VBN
cord-001835-0s7ok4uw	4020	28	resistance	resistance	NN
cord-001835-0s7ok4uw	4020	29	to	to	IN
cord-001835-0s7ok4uw	4020	30	degradation	degradation	NN
cord-001835-0s7ok4uw	4020	31	in	in	IN
cord-001835-0s7ok4uw	4020	32	E.	E.	NNP
cord-001835-0s7ok4uw	4020	33	coli	coli	VBZ
cord-001835-0s7ok4uw	4020	34	ABSTRACT	abstract	JJ
cord-001835-0s7ok4uw	4020	35	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	4020	36	expression	expression	NN
cord-001835-0s7ok4uw	4020	37	systems	system	NNS
cord-001835-0s7ok4uw	4020	38	.	.	.
cord-001835-0s7ok4uw	4021	1	The	the	DT
cord-001835-0s7ok4uw	4021	2	B	B	NNP
cord-001835-0s7ok4uw	4021	3	domain	domain	NN
cord-001835-0s7ok4uw	4021	4	of	of	IN
cord-001835-0s7ok4uw	4021	5	Staphylococcal	Staphylococcal	NNP
cord-001835-0s7ok4uw	4021	6	Protein	Protein	NNP
cord-001835-0s7ok4uw	4021	7	A	A	NNP
cord-001835-0s7ok4uw	4021	8	(	(	-LRB-
cord-001835-0s7ok4uw	4021	9	AB	ab	NN
cord-001835-0s7ok4uw	4021	10	)	)	-RRB-
cord-001835-0s7ok4uw	4021	11	and	and	CC
cord-001835-0s7ok4uw	4021	12	the	the	DT
cord-001835-0s7ok4uw	4021	13	homeobox	homeobox	NN
cord-001835-0s7ok4uw	4021	14	DNA	dna	NN
cord-001835-0s7ok4uw	4021	15	-	-	HYPH
cord-001835-0s7ok4uw	4021	16	binding	bind	VBG
cord-001835-0s7ok4uw	4021	17	domain	domain	NN
cord-001835-0s7ok4uw	4021	18	from	from	IN
cord-001835-0s7ok4uw	4021	19	D.	D.	NNP
cord-001835-0s7ok4uw	4021	20	melanogaster	melanogaster	NN
cord-001835-0s7ok4uw	4021	21	Engrailed	Engrailed	NNP
cord-001835-0s7ok4uw	4021	22	(	(	-LRB-
cord-001835-0s7ok4uw	4021	23	En	En	NNP
cord-001835-0s7ok4uw	4021	24	)	)	-RRB-
cord-001835-0s7ok4uw	4021	25	are	be	VBP
cord-001835-0s7ok4uw	4021	26	small	small	JJ
cord-001835-0s7ok4uw	4021	27	3-helix	3-helix	CD
cord-001835-0s7ok4uw	4021	28	bundles	bundle	NNS
cord-001835-0s7ok4uw	4021	29	.	.	.
cord-001835-0s7ok4uw	4022	1	These	these	DT
cord-001835-0s7ok4uw	4022	2	domains	domain	NNS
cord-001835-0s7ok4uw	4022	3	do	do	VBP
cord-001835-0s7ok4uw	4022	4	not	not	RB
cord-001835-0s7ok4uw	4022	5	appreciably	appreciably	RB
cord-001835-0s7ok4uw	4022	6	accumulate	accumulate	VB
cord-001835-0s7ok4uw	4022	7	in	in	IN
cord-001835-0s7ok4uw	4022	8	the	the	DT
cord-001835-0s7ok4uw	4022	9	E.	E.	NNP
cord-001835-0s7ok4uw	4022	10	coli	coli	NNS
cord-001835-0s7ok4uw	4023	1	BL21	BL21	NNP
cord-001835-0s7ok4uw	4023	2	(	(	-LRB-
cord-001835-0s7ok4uw	4023	3	DE3	DE3	NNP
cord-001835-0s7ok4uw	4023	4	)	)	-RRB-
cord-001835-0s7ok4uw	4023	5	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	4023	6	when	when	WRB
cord-001835-0s7ok4uw	4023	7	expression	expression	NN
cord-001835-0s7ok4uw	4023	8	in	in	IN
cord-001835-0s7ok4uw	4023	9	a	a	DT
cord-001835-0s7ok4uw	4023	10	pET	pet	CD
cord-001835-0s7ok4uw	4023	11	vector	vector	NN
cord-001835-0s7ok4uw	4023	12	is	be	VBZ
cord-001835-0s7ok4uw	4023	13	chemically	chemically	RB
cord-001835-0s7ok4uw	4023	14	induced	induce	VBN
cord-001835-0s7ok4uw	4023	15	.	.	.
cord-001835-0s7ok4uw	4024	1	This	this	DT
cord-001835-0s7ok4uw	4024	2	is	be	VBZ
cord-001835-0s7ok4uw	4024	3	likely	likely	JJ
cord-001835-0s7ok4uw	4024	4	due	due	JJ
cord-001835-0s7ok4uw	4024	5	to	to	TO
cord-001835-0s7ok4uw	4024	6	host	host	VB
cord-001835-0s7ok4uw	4024	7	protein	protein	NN
cord-001835-0s7ok4uw	4024	8	degradation	degradation	NN
cord-001835-0s7ok4uw	4024	9	/	/	SYM
cord-001835-0s7ok4uw	4024	10	recycling	recycling	NN
cord-001835-0s7ok4uw	4024	11	factors	factor	NNS
cord-001835-0s7ok4uw	4024	12	that	that	WDT
cord-001835-0s7ok4uw	4024	13	function	function	VBP
cord-001835-0s7ok4uw	4024	14	to	to	TO
cord-001835-0s7ok4uw	4024	15	efficiently	efficiently	RB
cord-001835-0s7ok4uw	4024	16	degrade	degrade	VB
cord-001835-0s7ok4uw	4024	17	these	these	DT
cord-001835-0s7ok4uw	4024	18	two	two	CD
cord-001835-0s7ok4uw	4024	19	proteins	protein	NNS
cord-001835-0s7ok4uw	4024	20	.	.	.
cord-001835-0s7ok4uw	4025	1	Addition	addition	NN
cord-001835-0s7ok4uw	4025	2	of	of	IN
cord-001835-0s7ok4uw	4025	3	sequences	sequence	NNS
cord-001835-0s7ok4uw	4025	4	encoding	encode	VBG
cord-001835-0s7ok4uw	4025	5	either	either	CC
cord-001835-0s7ok4uw	4025	6	of	of	IN
cord-001835-0s7ok4uw	4025	7	two	two	CD
cord-001835-0s7ok4uw	4025	8	amino	amino	NN
cord-001835-0s7ok4uw	4025	9	-	-	HYPH
cord-001835-0s7ok4uw	4025	10	terminal	terminal	NN
cord-001835-0s7ok4uw	4025	11	beta	beta	NN
cord-001835-0s7ok4uw	4025	12	-	-	HYPH
cord-001835-0s7ok4uw	4025	13	hairpins	hairpin	NNS
cord-001835-0s7ok4uw	4025	14	to	to	IN
cord-001835-0s7ok4uw	4025	15	either	either	CC
cord-001835-0s7ok4uw	4025	16	the	the	DT
cord-001835-0s7ok4uw	4025	17	N	N	NNP
cord-001835-0s7ok4uw	4025	18	-	-	HYPH
cord-001835-0s7ok4uw	4025	19	or	or	CC
cord-001835-0s7ok4uw	4025	20	C	c	NN
cord-001835-0s7ok4uw	4025	21	-	-	HYPH
cord-001835-0s7ok4uw	4025	22	terminus	terminus	NN
cord-001835-0s7ok4uw	4025	23	of	of	IN
cord-001835-0s7ok4uw	4025	24	AB	AB	NNP
cord-001835-0s7ok4uw	4025	25	and	and	CC
cord-001835-0s7ok4uw	4025	26	En	En	NNP
cord-001835-0s7ok4uw	4025	27	results	result	NNS
cord-001835-0s7ok4uw	4025	28	in	in	IN
cord-001835-0s7ok4uw	4025	29	the	the	DT
cord-001835-0s7ok4uw	4025	30	accumulation	accumulation	NN
cord-001835-0s7ok4uw	4025	31	of	of	IN
cord-001835-0s7ok4uw	4025	32	large	large	JJ
cord-001835-0s7ok4uw	4025	33	amounts	amount	NNS
cord-001835-0s7ok4uw	4025	34	of	of	IN
cord-001835-0s7ok4uw	4025	35	these	these	DT
cord-001835-0s7ok4uw	4025	36	new	new	JJ
cord-001835-0s7ok4uw	4025	37	chimeric	chimeric	JJ
cord-001835-0s7ok4uw	4025	38	proteins	protein	NNS
cord-001835-0s7ok4uw	4025	39	.	.	.
cord-001835-0s7ok4uw	4026	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	4026	2	,	,	,
cord-001835-0s7ok4uw	4026	3	destabilization	destabilization	NN
cord-001835-0s7ok4uw	4026	4	of	of	IN
cord-001835-0s7ok4uw	4026	5	the	the	DT
cord-001835-0s7ok4uw	4026	6	AB	ab	NN
cord-001835-0s7ok4uw	4026	7	or	or	CC
cord-001835-0s7ok4uw	4026	8	En	en	IN
cord-001835-0s7ok4uw	4026	9	sequence	sequence	NN
cord-001835-0s7ok4uw	4026	10	does	do	VBZ
cord-001835-0s7ok4uw	4026	11	not	not	RB
cord-001835-0s7ok4uw	4026	12	abolish	abolish	VB
cord-001835-0s7ok4uw	4026	13	the	the	DT
cord-001835-0s7ok4uw	4026	14	expression	expression	NN
cord-001835-0s7ok4uw	4026	15	enhancement	enhancement	NN
cord-001835-0s7ok4uw	4026	16	effect	effect	NN
cord-001835-0s7ok4uw	4026	17	of	of	IN
cord-001835-0s7ok4uw	4026	18	the	the	DT
cord-001835-0s7ok4uw	4026	19	beta	beta	NN
cord-001835-0s7ok4uw	4026	20	-	-	HYPH
cord-001835-0s7ok4uw	4026	21	hairpin	hairpin	JJ
cord-001835-0s7ok4uw	4026	22	addition	addition	NN
cord-001835-0s7ok4uw	4026	23	.	.	.
cord-001835-0s7ok4uw	4027	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4027	2	have	have	VBP
cord-001835-0s7ok4uw	4027	3	investigated	investigate	VBN
cord-001835-0s7ok4uw	4027	4	the	the	DT
cord-001835-0s7ok4uw	4027	5	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	4027	6	origins	origin	NNS
cord-001835-0s7ok4uw	4027	7	and	and	CC
cord-001835-0s7ok4uw	4027	8	effects	effect	NNS
cord-001835-0s7ok4uw	4027	9	of	of	IN
cord-001835-0s7ok4uw	4027	10	the	the	DT
cord-001835-0s7ok4uw	4027	11	beta	beta	NN
cord-001835-0s7ok4uw	4027	12	-	-	HYPH
cord-001835-0s7ok4uw	4027	13	hairpin	hairpin	JJ
cord-001835-0s7ok4uw	4027	14	additions	addition	NNS
cord-001835-0s7ok4uw	4027	15	using	use	VBG
cord-001835-0s7ok4uw	4027	16	circular	circular	JJ
cord-001835-0s7ok4uw	4027	17	dichroism	dichroism	NN
cord-001835-0s7ok4uw	4027	18	(	(	-LRB-
cord-001835-0s7ok4uw	4027	19	CD	CD	NNP
cord-001835-0s7ok4uw	4027	20	)	)	-RRB-
cord-001835-0s7ok4uw	4027	21	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	4027	22	,	,	,
cord-001835-0s7ok4uw	4027	23	and	and	CC
cord-001835-0s7ok4uw	4027	24	have	have	VBP
cord-001835-0s7ok4uw	4027	25	determined	determine	VBN
cord-001835-0s7ok4uw	4027	26	that	that	IN
cord-001835-0s7ok4uw	4027	27	the	the	DT
cord-001835-0s7ok4uw	4027	28	added	add	VBN
cord-001835-0s7ok4uw	4027	29	sequence	sequence	NN
cord-001835-0s7ok4uw	4027	30	does	do	VBZ
cord-001835-0s7ok4uw	4027	31	not	not	RB
cord-001835-0s7ok4uw	4027	32	significantly	significantly	RB
cord-001835-0s7ok4uw	4027	33	perturb	perturb	VB
cord-001835-0s7ok4uw	4027	34	the	the	DT
cord-001835-0s7ok4uw	4027	35	secondary	secondary	JJ
cord-001835-0s7ok4uw	4027	36	structure	structure	NN
cord-001835-0s7ok4uw	4027	37	of	of	IN
cord-001835-0s7ok4uw	4027	38	AB	AB	NNP
cord-001835-0s7ok4uw	4027	39	or	or	CC
cord-001835-0s7ok4uw	4027	40	En	En	NNP
cord-001835-0s7ok4uw	4027	41	,	,	,
cord-001835-0s7ok4uw	4027	42	nor	nor	CC
cord-001835-0s7ok4uw	4027	43	does	do	VBZ
cord-001835-0s7ok4uw	4027	44	it	-PRON-	PRP
cord-001835-0s7ok4uw	4027	45	significantly	significantly	RB
cord-001835-0s7ok4uw	4027	46	influence	influence	VB
cord-001835-0s7ok4uw	4027	47	the	the	DT
cord-001835-0s7ok4uw	4027	48	unfolding	unfold	VBG
cord-001835-0s7ok4uw	4027	49	temperature	temperature	NN
cord-001835-0s7ok4uw	4027	50	(	(	-LRB-
cord-001835-0s7ok4uw	4027	51	Tm	Tm	NNP
cord-001835-0s7ok4uw	4027	52	)	)	-RRB-
cord-001835-0s7ok4uw	4027	53	.	.	.
cord-001835-0s7ok4uw	4028	1	While	while	IN
cord-001835-0s7ok4uw	4028	2	investigation	investigation	NN
cord-001835-0s7ok4uw	4028	3	into	into	IN
cord-001835-0s7ok4uw	4028	4	the	the	DT
cord-001835-0s7ok4uw	4028	5	origin	origin	NN
cord-001835-0s7ok4uw	4028	6	of	of	IN
cord-001835-0s7ok4uw	4028	7	the	the	DT
cord-001835-0s7ok4uw	4028	8	accumulation	accumulation	NN
cord-001835-0s7ok4uw	4028	9	effect	effect	NN
cord-001835-0s7ok4uw	4028	10	is	be	VBZ
cord-001835-0s7ok4uw	4028	11	ongoing	ongoing	JJ
cord-001835-0s7ok4uw	4028	12	,	,	,
cord-001835-0s7ok4uw	4028	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	4028	14	hypothesize	hypothesize	VBP
cord-001835-0s7ok4uw	4028	15	that	that	IN
cord-001835-0s7ok4uw	4028	16	the	the	DT
cord-001835-0s7ok4uw	4028	17	addition	addition	NN
cord-001835-0s7ok4uw	4028	18	of	of	IN
cord-001835-0s7ok4uw	4028	19	the	the	DT
cord-001835-0s7ok4uw	4028	20	sequence	sequence	NN
cord-001835-0s7ok4uw	4028	21	is	be	VBZ
cord-001835-0s7ok4uw	4028	22	disruptive	disruptive	JJ
cord-001835-0s7ok4uw	4028	23	to	to	IN
cord-001835-0s7ok4uw	4028	24	recognition	recognition	NN
cord-001835-0s7ok4uw	4028	25	events	event	NNS
cord-001835-0s7ok4uw	4028	26	in	in	IN
cord-001835-0s7ok4uw	4028	27	the	the	DT
cord-001835-0s7ok4uw	4028	28	native	native	JJ
cord-001835-0s7ok4uw	4028	29	protein	protein	NN
cord-001835-0s7ok4uw	4028	30	degradation	degradation	NN
cord-001835-0s7ok4uw	4028	31	machinery	machinery	NN
cord-001835-0s7ok4uw	4028	32	in	in	IN
cord-001835-0s7ok4uw	4028	33	E.	E.	NNP
cord-001835-0s7ok4uw	4028	34	coli	coli	NNS
cord-001835-0s7ok4uw	4028	35	.	.	.
cord-001835-0s7ok4uw	4029	1	Thus	thus	RB
cord-001835-0s7ok4uw	4029	2	,	,	,
cord-001835-0s7ok4uw	4029	3	this	this	DT
cord-001835-0s7ok4uw	4029	4	approach	approach	NN
cord-001835-0s7ok4uw	4029	5	represents	represent	VBZ
cord-001835-0s7ok4uw	4029	6	both	both	CC
cord-001835-0s7ok4uw	4029	7	a	a	DT
cord-001835-0s7ok4uw	4029	8	biotechnological	biotechnological	JJ
cord-001835-0s7ok4uw	4029	9	tool	tool	NN
cord-001835-0s7ok4uw	4029	10	for	for	IN
cord-001835-0s7ok4uw	4029	11	expressing	express	VBG
cord-001835-0s7ok4uw	4029	12	helical	helical	JJ
cord-001835-0s7ok4uw	4029	13	peptides	peptide	NNS
cord-001835-0s7ok4uw	4029	14	recalcitrant	recalcitrant	JJ
cord-001835-0s7ok4uw	4029	15	to	to	IN
cord-001835-0s7ok4uw	4029	16	expression	expression	NN
cord-001835-0s7ok4uw	4029	17	,	,	,
cord-001835-0s7ok4uw	4029	18	as	as	RB
cord-001835-0s7ok4uw	4029	19	well	well	RB
cord-001835-0s7ok4uw	4029	20	as	as	IN
cord-001835-0s7ok4uw	4029	21	a	a	DT
cord-001835-0s7ok4uw	4029	22	system	system	NN
cord-001835-0s7ok4uw	4029	23	well	well	RB
cord-001835-0s7ok4uw	4029	24	-	-	HYPH
cord-001835-0s7ok4uw	4029	25	suited	suit	VBN
cord-001835-0s7ok4uw	4029	26	to	to	IN
cord-001835-0s7ok4uw	4029	27	probing	probing	JJ
cord-001835-0s7ok4uw	4029	28	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4029	29	of	of	IN
cord-001835-0s7ok4uw	4029	30	protein	protein	NN
cord-001835-0s7ok4uw	4029	31	recycling	recycling	NN
cord-001835-0s7ok4uw	4029	32	and	and	CC
cord-001835-0s7ok4uw	4029	33	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	4029	34	.	.	.
cord-001835-0s7ok4uw	4030	1	A	a	DT
cord-001835-0s7ok4uw	4030	2	special	special	JJ
cord-001835-0s7ok4uw	4030	3	class	class	NN
cord-001835-0s7ok4uw	4030	4	of	of	IN
cord-001835-0s7ok4uw	4030	5	these	these	DT
cord-001835-0s7ok4uw	4030	6	proteins	protein	NNS
cord-001835-0s7ok4uw	4030	7	are	be	VBP
cord-001835-0s7ok4uw	4030	8	lipidated	lipidate	VBN
cord-001835-0s7ok4uw	4030	9	proteins	protein	NNS
cord-001835-0s7ok4uw	4030	10	containing	contain	VBG
cord-001835-0s7ok4uw	4030	11	a	a	DT
cord-001835-0s7ok4uw	4030	12	glycosylphosphatidylinositol	glycosylphosphatidylinositol	NN
cord-001835-0s7ok4uw	4030	13	(	(	-LRB-
cord-001835-0s7ok4uw	4030	14	GPI	GPI	NNP
cord-001835-0s7ok4uw	4030	15	)	)	-RRB-
cord-001835-0s7ok4uw	4030	16	glycolipid	glycolipid	NNP
cord-001835-0s7ok4uw	4030	17	moiety	moiety	NNP
cord-001835-0s7ok4uw	4030	18	at	at	IN
cord-001835-0s7ok4uw	4030	19	the	the	DT
cord-001835-0s7ok4uw	4030	20	C	C	NNP
cord-001835-0s7ok4uw	4030	21	-	-	HYPH
cord-001835-0s7ok4uw	4030	22	terminus	terminus	NN
cord-001835-0s7ok4uw	4030	23	.	.	.
cord-001835-0s7ok4uw	4031	1	The	the	DT
cord-001835-0s7ok4uw	4031	2	lipid	lipid	NN
cord-001835-0s7ok4uw	4031	3	chains	chain	NNS
cord-001835-0s7ok4uw	4031	4	of	of	IN
cord-001835-0s7ok4uw	4031	5	the	the	DT
cord-001835-0s7ok4uw	4031	6	GPI	GPI	NNP
cord-001835-0s7ok4uw	4031	7	anchor	anchor	NN
cord-001835-0s7ok4uw	4031	8	molecule	molecule	NN
cord-001835-0s7ok4uw	4031	9	are	be	VBP
cord-001835-0s7ok4uw	4031	10	responsible	responsible	JJ
cord-001835-0s7ok4uw	4031	11	for	for	IN
cord-001835-0s7ok4uw	4031	12	the	the	DT
cord-001835-0s7ok4uw	4031	13	membrane	membrane	NNP
cord-001835-0s7ok4uw	4031	14	association	association	NNP
cord-001835-0s7ok4uw	4031	15	of	of	IN
cord-001835-0s7ok4uw	4031	16	the	the	DT
cord-001835-0s7ok4uw	4031	17	attached	attach	VBN
cord-001835-0s7ok4uw	4031	18	protein	protein	NN
cord-001835-0s7ok4uw	4031	19	.	.	.
cord-001835-0s7ok4uw	4032	1	A	a	DT
cord-001835-0s7ok4uw	4032	2	unique	unique	JJ
cord-001835-0s7ok4uw	4032	3	feature	feature	NN
cord-001835-0s7ok4uw	4032	4	of	of	IN
cord-001835-0s7ok4uw	4032	5	GPI	GPI	NNP
cord-001835-0s7ok4uw	4032	6	-	-	HYPH
cord-001835-0s7ok4uw	4032	7	anchored	anchor	VBN
cord-001835-0s7ok4uw	4032	8	proteins	protein	NNS
cord-001835-0s7ok4uw	4032	9	is	be	VBZ
cord-001835-0s7ok4uw	4032	10	that	that	IN
cord-001835-0s7ok4uw	4032	11	after	after	IN
cord-001835-0s7ok4uw	4032	12	isolation	isolation	NN
cord-001835-0s7ok4uw	4032	13	they	-PRON-	PRP
cord-001835-0s7ok4uw	4032	14	can	can	MD
cord-001835-0s7ok4uw	4032	15	be	be	VB
cord-001835-0s7ok4uw	4032	16	reinserted	reinserte	VBN
cord-001835-0s7ok4uw	4032	17	into	into	IN
cord-001835-0s7ok4uw	4032	18	the	the	DT
cord-001835-0s7ok4uw	4032	19	membrane	membrane	NN
cord-001835-0s7ok4uw	4032	20	of	of	IN
cord-001835-0s7ok4uw	4032	21	recipient	recipient	NN
cord-001835-0s7ok4uw	4032	22	cells	cell	NNS
cord-001835-0s7ok4uw	4032	23	with	with	IN
cord-001835-0s7ok4uw	4032	24	the	the	DT
cord-001835-0s7ok4uw	4032	25	retention	retention	NN
cord-001835-0s7ok4uw	4032	26	of	of	IN
cord-001835-0s7ok4uw	4032	27	the	the	DT
cord-001835-0s7ok4uw	4032	28	biological	biological	JJ
cord-001835-0s7ok4uw	4032	29	function	function	NN
cord-001835-0s7ok4uw	4032	30	.	.	.
cord-001835-0s7ok4uw	4033	1	Accordingly	accordingly	RB
cord-001835-0s7ok4uw	4033	2	,	,	,
cord-001835-0s7ok4uw	4033	3	the	the	DT
cord-001835-0s7ok4uw	4033	4	exogenous	exogenous	JJ
cord-001835-0s7ok4uw	4033	5	introduction	introduction	NN
cord-001835-0s7ok4uw	4033	6	of	of	IN
cord-001835-0s7ok4uw	4033	7	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	4033	8	GPI	GPI	NNP
cord-001835-0s7ok4uw	4033	9	-	-	HYPH
cord-001835-0s7ok4uw	4033	10	anchored	anchor	VBN
cord-001835-0s7ok4uw	4033	11	protein	protein	NN
cord-001835-0s7ok4uw	4033	12	analogues	analogue	NNS
cord-001835-0s7ok4uw	4033	13	into	into	IN
cord-001835-0s7ok4uw	4033	14	cell	cell	NN
cord-001835-0s7ok4uw	4033	15	membranes	membrane	NNS
cord-001835-0s7ok4uw	4033	16	is	be	VBZ
cord-001835-0s7ok4uw	4033	17	a	a	DT
cord-001835-0s7ok4uw	4033	18	useful	useful	JJ
cord-001835-0s7ok4uw	4033	19	method	method	NN
cord-001835-0s7ok4uw	4033	20	for	for	IN
cord-001835-0s7ok4uw	4033	21	visualizing	visualize	VBG
cord-001835-0s7ok4uw	4033	22	the	the	DT
cord-001835-0s7ok4uw	4033	23	cellular	cellular	JJ
cord-001835-0s7ok4uw	4033	24	traffic	traffic	NN
cord-001835-0s7ok4uw	4033	25	of	of	IN
cord-001835-0s7ok4uw	4033	26	membrane	membrane	NN
cord-001835-0s7ok4uw	4033	27	associated	associate	VBD
cord-001835-0s7ok4uw	4033	28	proteins	protein	NNS
cord-001835-0s7ok4uw	4033	29	and	and	CC
cord-001835-0s7ok4uw	4033	30	for	for	IN
cord-001835-0s7ok4uw	4033	31	engineering	engineering	NN
cord-001835-0s7ok4uw	4033	32	cell	cell	NN
cord-001835-0s7ok4uw	4033	33	surfaces	surface	NNS
cord-001835-0s7ok4uw	4033	34	.	.	.
cord-001835-0s7ok4uw	4034	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4034	2	have	have	VBP
cord-001835-0s7ok4uw	4034	3	recently	recently	RB
cord-001835-0s7ok4uw	4034	4	shown	show	VBN
cord-001835-0s7ok4uw	4034	5	that	that	IN
cord-001835-0s7ok4uw	4034	6	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	4034	7	can	can	MD
cord-001835-0s7ok4uw	4034	8	be	be	VB
cord-001835-0s7ok4uw	4034	9	applied	apply	VBN
cord-001835-0s7ok4uw	4034	10	for	for	IN
cord-001835-0s7ok4uw	4034	11	anchoring	anchor	VBG
cord-001835-0s7ok4uw	4034	12	proteins	protein	NNS
cord-001835-0s7ok4uw	4034	13	to	to	IN
cord-001835-0s7ok4uw	4034	14	the	the	DT
cord-001835-0s7ok4uw	4034	15	plasma	plasma	NN
cord-001835-0s7ok4uw	4034	16	membrane	membrane	NN
cord-001835-0s7ok4uw	4034	17	of	of	IN
cord-001835-0s7ok4uw	4034	18	live	live	JJ
cord-001835-0s7ok4uw	4034	19	cells	cell	NNS
cord-001835-0s7ok4uw	4034	20	without	without	IN
cord-001835-0s7ok4uw	4034	21	perturbing	perturb	VBG
cord-001835-0s7ok4uw	4034	22	the	the	DT
cord-001835-0s7ok4uw	4034	23	membrane	membrane	NN
cord-001835-0s7ok4uw	4034	24	.	.	.
cord-001835-0s7ok4uw	4035	1	In	in	IN
cord-001835-0s7ok4uw	4035	2	order	order	NN
cord-001835-0s7ok4uw	4035	3	to	to	TO
cord-001835-0s7ok4uw	4035	4	introduce	introduce	VB
cord-001835-0s7ok4uw	4035	5	proteins	protein	NNS
cord-001835-0s7ok4uw	4035	6	containing	contain	VBG
cord-001835-0s7ok4uw	4035	7	covalent	covalent	JJ
cord-001835-0s7ok4uw	4035	8	modifications	modification	NNS
cord-001835-0s7ok4uw	4035	9	that	that	WDT
cord-001835-0s7ok4uw	4035	10	are	be	VBP
cord-001835-0s7ok4uw	4035	11	not	not	RB
cord-001835-0s7ok4uw	4035	12	genetically	genetically	RB
cord-001835-0s7ok4uw	4035	13	encoded	encode	VBN
cord-001835-0s7ok4uw	4035	14	,	,	,
cord-001835-0s7ok4uw	4035	15	an	an	DT
cord-001835-0s7ok4uw	4035	16	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	4035	17	method	method	NN
cord-001835-0s7ok4uw	4035	18	was	be	VBD
cord-001835-0s7ok4uw	4035	19	considered	consider	VBN
cord-001835-0s7ok4uw	4035	20	and	and	CC
cord-001835-0s7ok4uw	4035	21	fused	fuse	VBN
cord-001835-0s7ok4uw	4035	22	with	with	IN
cord-001835-0s7ok4uw	4035	23	the	the	DT
cord-001835-0s7ok4uw	4035	24	C	C	NNP
cord-001835-0s7ok4uw	4035	25	-	-	HYPH
cord-001835-0s7ok4uw	4035	26	terminal	terminal	NN
cord-001835-0s7ok4uw	4035	27	cholesterylation	cholesterylation	NN
cord-001835-0s7ok4uw	4035	28	method	method	NN
cord-001835-0s7ok4uw	4035	29	.	.	.
cord-001835-0s7ok4uw	4036	1	The	the	DT
cord-001835-0s7ok4uw	4036	2	usefulness	usefulness	NN
cord-001835-0s7ok4uw	4036	3	of	of	IN
cord-001835-0s7ok4uw	4036	4	the	the	DT
cord-001835-0s7ok4uw	4036	5	method	method	NN
cord-001835-0s7ok4uw	4036	6	is	be	VBZ
cord-001835-0s7ok4uw	4036	7	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	4036	8	via	via	IN
cord-001835-0s7ok4uw	4036	9	the	the	DT
cord-001835-0s7ok4uw	4036	10	preparation	preparation	NN
cord-001835-0s7ok4uw	4036	11	of	of	IN
cord-001835-0s7ok4uw	4036	12	multimeric	multimeric	JJ
cord-001835-0s7ok4uw	4036	13	model	model	NN
cord-001835-0s7ok4uw	4036	14	proteins	protein	NNS
cord-001835-0s7ok4uw	4036	15	of	of	IN
cord-001835-0s7ok4uw	4036	16	40	40	CD
cord-001835-0s7ok4uw	4036	17	kDa	kDa	NNS
cord-001835-0s7ok4uw	4036	18	monomers	monomer	NNS
cord-001835-0s7ok4uw	4036	19	,	,	,
cord-001835-0s7ok4uw	4036	20	that	that	DT
cord-001835-0s7ok4uw	4036	21	is	be	VBZ
cord-001835-0s7ok4uw	4036	22	an	an	DT
cord-001835-0s7ok4uw	4036	23	appropriate	appropriate	JJ
cord-001835-0s7ok4uw	4036	24	representation	representation	NN
cord-001835-0s7ok4uw	4036	25	of	of	IN
cord-001835-0s7ok4uw	4036	26	the	the	DT
cord-001835-0s7ok4uw	4036	27	ligation	ligation	NN
cord-001835-0s7ok4uw	4036	28	of	of	IN
cord-001835-0s7ok4uw	4036	29	domain	domain	NN
cord-001835-0s7ok4uw	4036	30	size	size	NN
cord-001835-0s7ok4uw	4036	31	proteins	protein	NNS
cord-001835-0s7ok4uw	4036	32	.	.	.
cord-001835-0s7ok4uw	4037	1	Transmembrane	Transmembrane	NNP
cord-001835-0s7ok4uw	4037	2	domain	domain	NN
cord-001835-0s7ok4uw	4037	3	dimerization	dimerization	NN
cord-001835-0s7ok4uw	4037	4	drives	drive	VBZ
cord-001835-0s7ok4uw	4037	5	p75NTR	p75ntr	NN
cord-001835-0s7ok4uw	4037	6	partitioning	partitioning	NN
cord-001835-0s7ok4uw	4037	7	to	to	IN
cord-001835-0s7ok4uw	4037	8	lipid	lipid	NN
cord-001835-0s7ok4uw	4037	9	rafts	raft	NNS
cord-001835-0s7ok4uw	4038	1	Irmina	Irmina	NNP
cord-001835-0s7ok4uw	4038	2	Garc	Garc	NNP
cord-001835-0s7ok4uw	4038	3	ıa	ıa	IN
cord-001835-0s7ok4uw	4038	4	Carpio	Carpio	NNP
cord-001835-0s7ok4uw	4038	5	1	1	CD
cord-001835-0s7ok4uw	4038	6	,	,	,
cord-001835-0s7ok4uw	4038	7	Marc¸al	Marc¸al	NNP
cord-001835-0s7ok4uw	4038	8	Vilar	Vilar	NNP
cord-001835-0s7ok4uw	4038	9	1	1	CD
cord-001835-0s7ok4uw	4038	10	1	1	CD
cord-001835-0s7ok4uw	4038	11	Sociedad	Sociedad	NNP
cord-001835-0s7ok4uw	4038	12	de	de	NNP
cord-001835-0s7ok4uw	4038	13	Biof	Biof	NNP
cord-001835-0s7ok4uw	4038	14	ısica	ısica	NNP
cord-001835-0s7ok4uw	4038	15	de	de	FW
cord-001835-0s7ok4uw	4038	16	España	España	NNP
cord-001835-0s7ok4uw	4038	17	.	.	.
cord-001835-0s7ok4uw	4039	1	SBE	SBE	NNP
cord-001835-0s7ok4uw	4039	2	p75	p75	NNP
cord-001835-0s7ok4uw	4039	3	neurotrophin	neurotrophin	NNP
cord-001835-0s7ok4uw	4039	4	receptor	receptor	NN
cord-001835-0s7ok4uw	4039	5	(	(	-LRB-
cord-001835-0s7ok4uw	4039	6	p75NTR	p75NTR	NNP
cord-001835-0s7ok4uw	4039	7	)	)	-RRB-
cord-001835-0s7ok4uw	4039	8	,	,	,
cord-001835-0s7ok4uw	4039	9	is	be	VBZ
cord-001835-0s7ok4uw	4039	10	best	well	RBS
cord-001835-0s7ok4uw	4039	11	known	know	VBN
cord-001835-0s7ok4uw	4039	12	for	for	IN
cord-001835-0s7ok4uw	4039	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4039	14	role	role	NN
cord-001835-0s7ok4uw	4039	15	in	in	IN
cord-001835-0s7ok4uw	4039	16	mediating	mediate	VBG
cord-001835-0s7ok4uw	4039	17	neuron	neuron	NN
cord-001835-0s7ok4uw	4039	18	cell	cell	NN
cord-001835-0s7ok4uw	4039	19	death	death	NN
cord-001835-0s7ok4uw	4039	20	during	during	IN
cord-001835-0s7ok4uw	4039	21	development	development	NN
cord-001835-0s7ok4uw	4039	22	or	or	CC
cord-001835-0s7ok4uw	4039	23	after	after	IN
cord-001835-0s7ok4uw	4039	24	injury	injury	NN
cord-001835-0s7ok4uw	4040	1	but	but	CC
cord-001835-0s7ok4uw	4040	2	it	-PRON-	PRP
cord-001835-0s7ok4uw	4040	3	also	also	RB
cord-001835-0s7ok4uw	4040	4	regulates	regulate	VBZ
cord-001835-0s7ok4uw	4040	5	cell	cell	NN
cord-001835-0s7ok4uw	4040	6	proliferation	proliferation	NN
cord-001835-0s7ok4uw	4040	7	,	,	,
cord-001835-0s7ok4uw	4040	8	axon	axon	NN
cord-001835-0s7ok4uw	4040	9	guidance	guidance	NN
cord-001835-0s7ok4uw	4040	10	or	or	CC
cord-001835-0s7ok4uw	4040	11	survival	survival	NN
cord-001835-0s7ok4uw	4040	12	.	.	.
cord-001835-0s7ok4uw	4041	1	The	the	DT
cord-001835-0s7ok4uw	4041	2	key	key	NN
cord-001835-0s7ok4uw	4041	3	to	to	TO
cord-001835-0s7ok4uw	4041	4	understand	understand	VB
cord-001835-0s7ok4uw	4041	5	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4041	6	signaling	signaling	NN
cord-001835-0s7ok4uw	4041	7	could	could	MD
cord-001835-0s7ok4uw	4041	8	rely	rely	VB
cord-001835-0s7ok4uw	4041	9	in	in	IN
cord-001835-0s7ok4uw	4041	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4041	11	structure	structure	NN
cord-001835-0s7ok4uw	4041	12	and	and	CC
cord-001835-0s7ok4uw	4041	13	conformational	conformational	JJ
cord-001835-0s7ok4uw	4041	14	states	state	NNS
cord-001835-0s7ok4uw	4041	15	.	.	.
cord-001835-0s7ok4uw	4042	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4042	2	has	have	VBZ
cord-001835-0s7ok4uw	4042	3	been	be	VBN
cord-001835-0s7ok4uw	4042	4	described	describe	VBN
cord-001835-0s7ok4uw	4042	5	that	that	IN
cord-001835-0s7ok4uw	4042	6	p75	p75	NNP
cord-001835-0s7ok4uw	4042	7	forms	form	NNS
cord-001835-0s7ok4uw	4042	8	disulfide	disulfide	RB
cord-001835-0s7ok4uw	4042	9	-	-	HYPH
cord-001835-0s7ok4uw	4042	10	linked	link	VBN
cord-001835-0s7ok4uw	4042	11	dimmers	dimmer	NNS
cord-001835-0s7ok4uw	4042	12	through	through	IN
cord-001835-0s7ok4uw	4042	13	the	the	DT
cord-001835-0s7ok4uw	4042	14	Cys257	Cys257	NNP
cord-001835-0s7ok4uw	4042	15	in	in	IN
cord-001835-0s7ok4uw	4042	16	the	the	DT
cord-001835-0s7ok4uw	4042	17	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	4042	18	domain	domain	NN
cord-001835-0s7ok4uw	4042	19	which	which	WDT
cord-001835-0s7ok4uw	4042	20	are	be	VBP
cord-001835-0s7ok4uw	4042	21	essential	essential	JJ
cord-001835-0s7ok4uw	4042	22	for	for	IN
cord-001835-0s7ok4uw	4042	23	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4042	24	NGF	NGF	NNP
cord-001835-0s7ok4uw	4042	25	mediated	mediate	VBN
cord-001835-0s7ok4uw	4042	26	signaling	signaling	NN
cord-001835-0s7ok4uw	4042	27	.	.	.
cord-001835-0s7ok4uw	4043	1	Previous	previous	JJ
cord-001835-0s7ok4uw	4043	2	studies	study	NNS
cord-001835-0s7ok4uw	4043	3	have	have	VBP
cord-001835-0s7ok4uw	4043	4	shown	show	VBN
cord-001835-0s7ok4uw	4043	5	that	that	IN
cord-001835-0s7ok4uw	4043	6	p75	p75	NNP
cord-001835-0s7ok4uw	4043	7	is	be	VBZ
cord-001835-0s7ok4uw	4043	8	present	present	JJ
cord-001835-0s7ok4uw	4043	9	in	in	IN
cord-001835-0s7ok4uw	4043	10	lipid	lipid	NN
cord-001835-0s7ok4uw	4043	11	rafts	raft	NNS
cord-001835-0s7ok4uw	4043	12	,	,	,
cord-001835-0s7ok4uw	4043	13	where	where	WRB
cord-001835-0s7ok4uw	4043	14	it	-PRON-	PRP
cord-001835-0s7ok4uw	4043	15	interacts	interact	VBZ
cord-001835-0s7ok4uw	4043	16	with	with	IN
cord-001835-0s7ok4uw	4043	17	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	4043	18	adaptors	adaptor	NNS
cord-001835-0s7ok4uw	4043	19	to	to	TO
cord-001835-0s7ok4uw	4043	20	activate	activate	VB
cord-001835-0s7ok4uw	4043	21	different	different	JJ
cord-001835-0s7ok4uw	4043	22	signaling	signal	VBG
cord-001835-0s7ok4uw	4043	23	pathways	pathway	NNS
cord-001835-0s7ok4uw	4043	24	.	.	.
cord-001835-0s7ok4uw	4044	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4044	2	design	design	VBP
cord-001835-0s7ok4uw	4044	3	several	several	JJ
cord-001835-0s7ok4uw	4044	4	p75	p75	CD
cord-001835-0s7ok4uw	4044	5	mutants	mutant	NNS
cord-001835-0s7ok4uw	4044	6	in	in	IN
cord-001835-0s7ok4uw	4044	7	the	the	DT
cord-001835-0s7ok4uw	4044	8	TM	TM	NNP
cord-001835-0s7ok4uw	4044	9	domain	domain	NN
cord-001835-0s7ok4uw	4044	10	that	that	WDT
cord-001835-0s7ok4uw	4044	11	impairs	impair	VBZ
cord-001835-0s7ok4uw	4044	12	dimerization	dimerization	NN
cord-001835-0s7ok4uw	4044	13	and	and	CC
cord-001835-0s7ok4uw	4044	14	study	study	VB
cord-001835-0s7ok4uw	4044	15	the	the	DT
cord-001835-0s7ok4uw	4044	16	role	role	NN
cord-001835-0s7ok4uw	4044	17	of	of	IN
cord-001835-0s7ok4uw	4044	18	TM	TM	NNP
cord-001835-0s7ok4uw	4044	19	domain	domain	NN
cord-001835-0s7ok4uw	4044	20	dimerization	dimerization	NN
cord-001835-0s7ok4uw	4044	21	in	in	IN
cord-001835-0s7ok4uw	4044	22	lipid	lipid	NN
cord-001835-0s7ok4uw	4044	23	rafts	raft	NNS
cord-001835-0s7ok4uw	4044	24	recruitment	recruitment	NN
cord-001835-0s7ok4uw	4044	25	.	.	.
cord-001835-0s7ok4uw	4045	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4045	2	analysis	analysis	NN
cord-001835-0s7ok4uw	4045	3	suggests	suggest	VBZ
cord-001835-0s7ok4uw	4045	4	that	that	IN
cord-001835-0s7ok4uw	4045	5	p75	p75	NNP
cord-001835-0s7ok4uw	4045	6	TM	TM	NNP
cord-001835-0s7ok4uw	4045	7	domain	domain	NN
cord-001835-0s7ok4uw	4045	8	dimerization	dimerization	NN
cord-001835-0s7ok4uw	4045	9	influences	influence	VBZ
cord-001835-0s7ok4uw	4045	10	lipid	lipid	VBP
cord-001835-0s7ok4uw	4045	11	raft	raft	NN
cord-001835-0s7ok4uw	4045	12	partitioning	partitioning	NN
cord-001835-0s7ok4uw	4045	13	.	.	.
cord-001835-0s7ok4uw	4046	1	These	these	DT
cord-001835-0s7ok4uw	4046	2	results	result	NNS
cord-001835-0s7ok4uw	4046	3	could	could	MD
cord-001835-0s7ok4uw	4046	4	be	be	VB
cord-001835-0s7ok4uw	4046	5	a	a	DT
cord-001835-0s7ok4uw	4046	6	key	key	JJ
cord-001835-0s7ok4uw	4046	7	role	role	NN
cord-001835-0s7ok4uw	4046	8	to	to	TO
cord-001835-0s7ok4uw	4046	9	understand	understand	VB
cord-001835-0s7ok4uw	4046	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4046	11	signaling	signaling	NN
cord-001835-0s7ok4uw	4046	12	and	and	CC
cord-001835-0s7ok4uw	4046	13	processing	process	VBG
cord-001835-0s7ok4uw	4046	14	PI-079	pi-079	NN
cord-001835-0s7ok4uw	4046	15	Bioluminescent	Bioluminescent	NNP
cord-001835-0s7ok4uw	4046	16	sensor	sensor	NN
cord-001835-0s7ok4uw	4046	17	proteins	protein	NNS
cord-001835-0s7ok4uw	4046	18	for	for	IN
cord-001835-0s7ok4uw	4046	19	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	4046	20	drug	drug	NN
cord-001835-0s7ok4uw	4046	21	monitoring	monitoring	NN
cord-001835-0s7ok4uw	4046	22	of	of	IN
cord-001835-0s7ok4uw	4046	23	the	the	DT
cord-001835-0s7ok4uw	4046	24	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	4046	25	antibody	antibody	NN
cord-001835-0s7ok4uw	4046	26	Cetuximab	Cetuximab	NNP
cord-001835-0s7ok4uw	4046	27	Martijn	Martijn	NNP
cord-001835-0s7ok4uw	4046	28	Van	Van	NNP
cord-001835-0s7ok4uw	4046	29	Rosmalen	Rosmalen	NNP
cord-001835-0s7ok4uw	4046	30	1	1	CD
cord-001835-0s7ok4uw	4046	31	,	,	,
cord-001835-0s7ok4uw	4046	32	Remco	Remco	NNP
cord-001835-0s7ok4uw	4046	33	Arts	Arts	NNPS
cord-001835-0s7ok4uw	4046	34	1	1	CD
cord-001835-0s7ok4uw	4046	35	,	,	,
cord-001835-0s7ok4uw	4046	36	Brian	Brian	NNP
cord-001835-0s7ok4uw	4046	37	Janssen	Janssen	NNP
cord-001835-0s7ok4uw	4046	38	1	1	CD
cord-001835-0s7ok4uw	4046	39	,	,	,
cord-001835-0s7ok4uw	4046	40	Natalie	Natalie	NNP
cord-001835-0s7ok4uw	4046	41	Hendrikse	Hendrikse	NNP
cord-001835-0s7ok4uw	4046	42	1	1	CD
cord-001835-0s7ok4uw	4046	43	,	,	,
cord-001835-0s7ok4uw	4046	44	Dave	Dave	NNP
cord-001835-0s7ok4uw	4046	45	Wanders	Wanders	NNP
cord-001835-0s7ok4uw	4046	46	1	1	CD
cord-001835-0s7ok4uw	4046	47	,	,	,
cord-001835-0s7ok4uw	4046	48	Maarten	Maarten	NNP
cord-001835-0s7ok4uw	4046	49	Merkx	Merkx	NNP
cord-001835-0s7ok4uw	4046	50	1	1	CD
cord-001835-0s7ok4uw	4046	51	1	1	CD
cord-001835-0s7ok4uw	4046	52	Therapeutic	Therapeutic	NNP
cord-001835-0s7ok4uw	4046	53	Drug	Drug	NNP
cord-001835-0s7ok4uw	4046	54	Monitoring	Monitoring	NNP
cord-001835-0s7ok4uw	4046	55	(	(	-LRB-
cord-001835-0s7ok4uw	4046	56	TDM	TDM	NNP
cord-001835-0s7ok4uw	4046	57	)	)	-RRB-
cord-001835-0s7ok4uw	4046	58	-adapting	-adapte	VBG
cord-001835-0s7ok4uw	4046	59	the	the	DT
cord-001835-0s7ok4uw	4046	60	drug	drug	NN
cord-001835-0s7ok4uw	4046	61	dosage	dosage	NN
cord-001835-0s7ok4uw	4046	62	scheme	scheme	NN
cord-001835-0s7ok4uw	4046	63	to	to	IN
cord-001835-0s7ok4uw	4046	64	the	the	DT
cord-001835-0s7ok4uw	4046	65	individual	individual	JJ
cord-001835-0s7ok4uw	4046	66	patient	patient	NN
cord-001835-0s7ok4uw	4046	67	's	's	POS
cord-001835-0s7ok4uw	4046	68	pharmacokinetic	pharmacokinetic	JJ
cord-001835-0s7ok4uw	4046	69	and	and	CC
cord-001835-0s7ok4uw	4046	70	pharmacodynamic	pharmacodynamic	JJ
cord-001835-0s7ok4uw	4046	71	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	4046	72	-is	-is	.
cord-001835-0s7ok4uw	4047	1	still	still	RB
cord-001835-0s7ok4uw	4047	2	uncommon	uncommon	JJ
cord-001835-0s7ok4uw	4047	3	for	for	IN
cord-001835-0s7ok4uw	4047	4	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	4047	5	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	4047	6	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4047	7	,	,	,
cord-001835-0s7ok4uw	4047	8	despite	despite	IN
cord-001835-0s7ok4uw	4047	9	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	4047	10	studies	study	NNS
cord-001835-0s7ok4uw	4047	11	showing	show	VBG
cord-001835-0s7ok4uw	4047	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4047	13	potential	potential	JJ
cord-001835-0s7ok4uw	4047	14	benefits	benefit	NNS
cord-001835-0s7ok4uw	4047	15	.	.	.
cord-001835-0s7ok4uw	4048	1	One	one	CD
cord-001835-0s7ok4uw	4048	2	of	of	IN
cord-001835-0s7ok4uw	4048	3	the	the	DT
cord-001835-0s7ok4uw	4048	4	factors	factor	NNS
cord-001835-0s7ok4uw	4048	5	impairing	impair	VBG
cord-001835-0s7ok4uw	4048	6	TDM	tdm	NN
cord-001835-0s7ok4uw	4048	7	implementation	implementation	NN
cord-001835-0s7ok4uw	4048	8	is	be	VBZ
cord-001835-0s7ok4uw	4048	9	the	the	DT
cord-001835-0s7ok4uw	4048	10	lack	lack	NN
cord-001835-0s7ok4uw	4048	11	of	of	IN
cord-001835-0s7ok4uw	4048	12	equipment	equipment	NN
cord-001835-0s7ok4uw	4048	13	and	and	CC
cord-001835-0s7ok4uw	4048	14	trained	train	VBN
cord-001835-0s7ok4uw	4048	15	personnel	personnel	NNS
cord-001835-0s7ok4uw	4048	16	to	to	TO
cord-001835-0s7ok4uw	4048	17	regularly	regularly	RB
cord-001835-0s7ok4uw	4048	18	measure	measure	VB
cord-001835-0s7ok4uw	4048	19	drug	drug	NN
cord-001835-0s7ok4uw	4048	20	concentrations	concentration	NNS
cord-001835-0s7ok4uw	4048	21	in	in	IN
cord-001835-0s7ok4uw	4048	22	patients	patient	NNS
cord-001835-0s7ok4uw	4048	23	receiving	receive	VBG
cord-001835-0s7ok4uw	4048	24	treatment	treatment	NN
cord-001835-0s7ok4uw	4048	25	.	.	.
cord-001835-0s7ok4uw	4049	1	Point	point	NN
cord-001835-0s7ok4uw	4049	2	-	-	HYPH
cord-001835-0s7ok4uw	4049	3	of	of	IN
cord-001835-0s7ok4uw	4049	4	-	-	HYPH
cord-001835-0s7ok4uw	4049	5	care	care	NN
cord-001835-0s7ok4uw	4049	6	diagnostic	diagnostic	JJ
cord-001835-0s7ok4uw	4049	7	devices	device	NNS
cord-001835-0s7ok4uw	4049	8	which	which	WDT
cord-001835-0s7ok4uw	4049	9	could	could	MD
cord-001835-0s7ok4uw	4049	10	be	be	VB
cord-001835-0s7ok4uw	4049	11	used	use	VBN
cord-001835-0s7ok4uw	4049	12	by	by	IN
cord-001835-0s7ok4uw	4049	13	patients	patient	NNS
cord-001835-0s7ok4uw	4049	14	themselves	-PRON-	PRP
cord-001835-0s7ok4uw	4049	15	or	or	CC
cord-001835-0s7ok4uw	4049	16	by	by	IN
cord-001835-0s7ok4uw	4049	17	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4049	18	general	general	JJ
cord-001835-0s7ok4uw	4049	19	practitioners	practitioner	NNS
cord-001835-0s7ok4uw	4049	20	would	would	MD
cord-001835-0s7ok4uw	4049	21	greatly	greatly	RB
cord-001835-0s7ok4uw	4049	22	advance	advance	VB
cord-001835-0s7ok4uw	4049	23	the	the	DT
cord-001835-0s7ok4uw	4049	24	feasibility	feasibility	NN
cord-001835-0s7ok4uw	4049	25	of	of	IN
cord-001835-0s7ok4uw	4049	26	TDM	tdm	NN
cord-001835-0s7ok4uw	4049	27	.	.	.
cord-001835-0s7ok4uw	4050	1	Here	here	RB
cord-001835-0s7ok4uw	4050	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	4050	3	present	present	VBP
cord-001835-0s7ok4uw	4050	4	a	a	DT
cord-001835-0s7ok4uw	4050	5	biosensor	biosensor	NN
cord-001835-0s7ok4uw	4050	6	for	for	IN
cord-001835-0s7ok4uw	4050	7	the	the	DT
cord-001835-0s7ok4uw	4050	8	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	4050	9	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	4050	10	antibody	antibody	NN
cord-001835-0s7ok4uw	4050	11	Cetuximab	Cetuximab	NNP
cord-001835-0s7ok4uw	4050	12	.	.	.
cord-001835-0s7ok4uw	4051	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4051	2	developed	develop	VBD
cord-001835-0s7ok4uw	4051	3	a	a	DT
cord-001835-0s7ok4uw	4051	4	series	series	NN
cord-001835-0s7ok4uw	4051	5	of	of	IN
cord-001835-0s7ok4uw	4051	6	cyclic	cyclic	JJ
cord-001835-0s7ok4uw	4051	7	peptides	peptide	NNS
cord-001835-0s7ok4uw	4051	8	that	that	WDT
cord-001835-0s7ok4uw	4051	9	specifically	specifically	RB
cord-001835-0s7ok4uw	4051	10	recognize	recognize	VBP
cord-001835-0s7ok4uw	4051	11	Cetuximab	Cetuximab	NNP
cord-001835-0s7ok4uw	4051	12	,	,	,
cord-001835-0s7ok4uw	4051	13	covering	cover	VBG
cord-001835-0s7ok4uw	4051	14	a	a	DT
cord-001835-0s7ok4uw	4051	15	fourfold	fourfold	JJ
cord-001835-0s7ok4uw	4051	16	range	range	NN
cord-001835-0s7ok4uw	4051	17	of	of	IN
cord-001835-0s7ok4uw	4051	18	affinities	affinity	NNS
cord-001835-0s7ok4uw	4051	19	,	,	,
cord-001835-0s7ok4uw	4051	20	and	and	CC
cord-001835-0s7ok4uw	4051	21	incorporated	incorporate	VBD
cord-001835-0s7ok4uw	4051	22	these	these	DT
cord-001835-0s7ok4uw	4051	23	cyclic	cyclic	JJ
cord-001835-0s7ok4uw	4051	24	peptide	peptide	NN
cord-001835-0s7ok4uw	4051	25	sequences	sequence	NNS
cord-001835-0s7ok4uw	4051	26	into	into	IN
cord-001835-0s7ok4uw	4051	27	a	a	DT
cord-001835-0s7ok4uw	4051	28	set	set	NN
cord-001835-0s7ok4uw	4051	29	of	of	IN
cord-001835-0s7ok4uw	4051	30	luminescent	luminescent	JJ
cord-001835-0s7ok4uw	4051	31	sensor	sensor	NN
cord-001835-0s7ok4uw	4051	32	proteins	protein	NNS
cord-001835-0s7ok4uw	4051	33	.	.	.
cord-001835-0s7ok4uw	4052	1	The	the	DT
cord-001835-0s7ok4uw	4052	2	sensors	sensor	NNS
cord-001835-0s7ok4uw	4052	3	translate	translate	VBP
cord-001835-0s7ok4uw	4052	4	cetuximab	cetuximab	NN
cord-001835-0s7ok4uw	4052	5	concentrations	concentration	NNS
cord-001835-0s7ok4uw	4052	6	into	into	IN
cord-001835-0s7ok4uw	4052	7	a	a	DT
cord-001835-0s7ok4uw	4052	8	change	change	NN
cord-001835-0s7ok4uw	4052	9	in	in	IN
cord-001835-0s7ok4uw	4052	10	emission	emission	NN
cord-001835-0s7ok4uw	4052	11	color	color	NN
cord-001835-0s7ok4uw	4052	12	that	that	WDT
cord-001835-0s7ok4uw	4052	13	can	can	MD
cord-001835-0s7ok4uw	4052	14	be	be	VB
cord-001835-0s7ok4uw	4052	15	read	read	VBN
cord-001835-0s7ok4uw	4052	16	out	out	RP
cord-001835-0s7ok4uw	4052	17	using	use	VBG
cord-001835-0s7ok4uw	4052	18	a	a	DT
cord-001835-0s7ok4uw	4052	19	mobile	mobile	JJ
cord-001835-0s7ok4uw	4052	20	phone	phone	NN
cord-001835-0s7ok4uw	4052	21	camera	camera	NN
cord-001835-0s7ok4uw	4052	22	.	.	.
cord-001835-0s7ok4uw	4053	1	Together	together	RB
cord-001835-0s7ok4uw	4053	2	,	,	,
cord-001835-0s7ok4uw	4053	3	these	these	DT
cord-001835-0s7ok4uw	4053	4	sensors	sensor	NNS
cord-001835-0s7ok4uw	4053	5	can	can	MD
cord-001835-0s7ok4uw	4053	6	quantify	quantify	VB
cord-001835-0s7ok4uw	4053	7	cetuximab	cetuximab	JJ
cord-001835-0s7ok4uw	4053	8	levels	level	NNS
cord-001835-0s7ok4uw	4053	9	within	within	IN
cord-001835-0s7ok4uw	4053	10	the	the	DT
cord-001835-0s7ok4uw	4053	11	relevant	relevant	JJ
cord-001835-0s7ok4uw	4053	12	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	4053	13	concentration	concentration	NN
cord-001835-0s7ok4uw	4053	14	range	range	NN
cord-001835-0s7ok4uw	4053	15	and	and	CC
cord-001835-0s7ok4uw	4053	16	we	-PRON-	PRP
cord-001835-0s7ok4uw	4053	17	propose	propose	VBP
cord-001835-0s7ok4uw	4053	18	that	that	IN
cord-001835-0s7ok4uw	4053	19	they	-PRON-	PRP
cord-001835-0s7ok4uw	4053	20	can	can	MD
cord-001835-0s7ok4uw	4053	21	be	be	VB
cord-001835-0s7ok4uw	4053	22	used	use	VBN
cord-001835-0s7ok4uw	4053	23	for	for	IN
cord-001835-0s7ok4uw	4053	24	Therapeutic	Therapeutic	NNP
cord-001835-0s7ok4uw	4053	25	Drug	Drug	NNP
cord-001835-0s7ok4uw	4053	26	Monitoring	Monitoring	NNP
cord-001835-0s7ok4uw	4053	27	applications	application	NNS
cord-001835-0s7ok4uw	4053	28	.	.	.
cord-001835-0s7ok4uw	4054	1	Genetically	genetically	RB
cord-001835-0s7ok4uw	4054	2	encoded	encode	VBN
cord-001835-0s7ok4uw	4054	3	biosensor	biosensor	NN
cord-001835-0s7ok4uw	4054	4	for	for	IN
cord-001835-0s7ok4uw	4054	5	cell	cell	NN
cord-001835-0s7ok4uw	4054	6	permeability	permeability	NN
cord-001835-0s7ok4uw	4054	7	of	of	IN
cord-001835-0s7ok4uw	4054	8	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4054	9	of	of	IN
cord-001835-0s7ok4uw	4054	10	the	the	DT
cord-001835-0s7ok4uw	4054	11	p53-HDM2	p53-HDM2	NNP
cord-001835-0s7ok4uw	4054	12	interaction	interaction	NN
cord-001835-0s7ok4uw	4054	13	Silvia	Silvia	NNP
cord-001835-0s7ok4uw	4054	14	Scarabelli	Scarabelli	NNP
cord-001835-0s7ok4uw	4054	15	1	1	CD
cord-001835-0s7ok4uw	4054	16	,	,	,
cord-001835-0s7ok4uw	4054	17	Thomas	Thomas	NNP
cord-001835-0s7ok4uw	4054	18	Vorherr	Vorherr	NNP
cord-001835-0s7ok4uw	4054	19	2	2	CD
cord-001835-0s7ok4uw	4054	20	,	,	,
cord-001835-0s7ok4uw	4054	21	Kai	Kai	NNP
cord-001835-0s7ok4uw	4054	22	Johnsson	Johnsson	NNP
cord-001835-0s7ok4uw	4054	23	1	1	CD
cord-001835-0s7ok4uw	4054	24	1	1	CD
cord-001835-0s7ok4uw	4054	25	Ecole	Ecole	NNP
cord-001835-0s7ok4uw	4054	26	Polytechnique	Polytechnique	NNP
cord-001835-0s7ok4uw	4054	27	F	F	NNP
cord-001835-0s7ok4uw	4054	28	ed	ed	NN
cord-001835-0s7ok4uw	4054	29	erale	erale	NN
cord-001835-0s7ok4uw	4054	30	de	de	FW
cord-001835-0s7ok4uw	4054	31	Lausanne	Lausanne	NNP
cord-001835-0s7ok4uw	4054	32	,	,	,
cord-001835-0s7ok4uw	4055	1	2	2	CD
cord-001835-0s7ok4uw	4055	2	 	 	_SP
cord-001835-0s7ok4uw	4056	1	The	the	DT
cord-001835-0s7ok4uw	4056	2	evaluation	evaluation	NN
cord-001835-0s7ok4uw	4056	3	of	of	IN
cord-001835-0s7ok4uw	4056	4	the	the	DT
cord-001835-0s7ok4uw	4056	5	permeability	permeability	NN
cord-001835-0s7ok4uw	4056	6	across	across	IN
cord-001835-0s7ok4uw	4056	7	the	the	DT
cord-001835-0s7ok4uw	4056	8	cellular	cellular	JJ
cord-001835-0s7ok4uw	4056	9	membrane	membrane	NN
cord-001835-0s7ok4uw	4056	10	is	be	VBZ
cord-001835-0s7ok4uw	4056	11	a	a	DT
cord-001835-0s7ok4uw	4056	12	key	key	JJ
cord-001835-0s7ok4uw	4056	13	step	step	NN
cord-001835-0s7ok4uw	4056	14	in	in	IN
cord-001835-0s7ok4uw	4056	15	the	the	DT
cord-001835-0s7ok4uw	4056	16	development	development	NN
cord-001835-0s7ok4uw	4056	17	of	of	IN
cord-001835-0s7ok4uw	4056	18	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	4056	19	,	,	,
cord-001835-0s7ok4uw	4056	20	since	since	IN
cord-001835-0s7ok4uw	4056	21	it	-PRON-	PRP
cord-001835-0s7ok4uw	4056	22	affects	affect	VBZ
cord-001835-0s7ok4uw	4056	23	the	the	DT
cord-001835-0s7ok4uw	4056	24	distribution	distribution	NN
cord-001835-0s7ok4uw	4056	25	and	and	CC
cord-001835-0s7ok4uw	4056	26	the	the	DT
cord-001835-0s7ok4uw	4056	27	efficacy	efficacy	NN
cord-001835-0s7ok4uw	4056	28	of	of	IN
cord-001835-0s7ok4uw	4056	29	the	the	DT
cord-001835-0s7ok4uw	4056	30	latters	latter	NNS
cord-001835-0s7ok4uw	4056	31	.	.	.
cord-001835-0s7ok4uw	4057	1	Reliable	reliable	JJ
cord-001835-0s7ok4uw	4057	2	and	and	CC
cord-001835-0s7ok4uw	4057	3	versatile	versatile	JJ
cord-001835-0s7ok4uw	4057	4	techniques	technique	NNS
cord-001835-0s7ok4uw	4057	5	for	for	IN
cord-001835-0s7ok4uw	4057	6	the	the	DT
cord-001835-0s7ok4uw	4057	7	determination	determination	NN
cord-001835-0s7ok4uw	4057	8	of	of	IN
cord-001835-0s7ok4uw	4057	9	structural	structural	JJ
cord-001835-0s7ok4uw	4057	10	permeability	permeability	NN
cord-001835-0s7ok4uw	4057	11	determinants	determinant	NNS
cord-001835-0s7ok4uw	4057	12	of	of	IN
cord-001835-0s7ok4uw	4057	13	molecules	molecule	NNS
cord-001835-0s7ok4uw	4057	14	and	and	CC
cord-001835-0s7ok4uw	4057	15	information	information	NN
cord-001835-0s7ok4uw	4057	16	about	about	IN
cord-001835-0s7ok4uw	4057	17	the	the	DT
cord-001835-0s7ok4uw	4057	18	entry	entry	NN
cord-001835-0s7ok4uw	4057	19	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	4057	20	are	be	VBP
cord-001835-0s7ok4uw	4057	21	still	still	RB
cord-001835-0s7ok4uw	4057	22	missing	miss	VBG
cord-001835-0s7ok4uw	4057	23	.	.	.
cord-001835-0s7ok4uw	4058	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4058	2	introduced	introduce	VBD
cord-001835-0s7ok4uw	4058	3	in	in	IN
cord-001835-0s7ok4uw	4058	4	the	the	DT
cord-001835-0s7ok4uw	4058	5	past	past	NN
cord-001835-0s7ok4uw	4058	6	a	a	DT
cord-001835-0s7ok4uw	4058	7	class	class	NN
cord-001835-0s7ok4uw	4058	8	of	of	IN
cord-001835-0s7ok4uw	4058	9	semi	semi	JJ
cord-001835-0s7ok4uw	4058	10	-	-	JJ
cord-001835-0s7ok4uw	4058	11	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	4058	12	ratiometric	ratiometric	JJ
cord-001835-0s7ok4uw	4058	13	sensor	sensor	NN
cord-001835-0s7ok4uw	4058	14	proteins	protein	NNS
cord-001835-0s7ok4uw	4058	15	(	(	-LRB-
cord-001835-0s7ok4uw	4058	16	Snifits	Snifits	NNP
cord-001835-0s7ok4uw	4058	17	)	)	-RRB-
cord-001835-0s7ok4uw	4058	18	that	that	WDT
cord-001835-0s7ok4uw	4058	19	has	have	VBZ
cord-001835-0s7ok4uw	4058	20	been	be	VBN
cord-001835-0s7ok4uw	4058	21	shown	show	VBN
cord-001835-0s7ok4uw	4058	22	to	to	TO
cord-001835-0s7ok4uw	4058	23	be	be	VB
cord-001835-0s7ok4uw	4058	24	suitable	suitable	JJ
cord-001835-0s7ok4uw	4058	25	for	for	IN
cord-001835-0s7ok4uw	4058	26	the	the	DT
cord-001835-0s7ok4uw	4058	27	measurement	measurement	NN
cord-001835-0s7ok4uw	4058	28	of	of	IN
cord-001835-0s7ok4uw	4058	29	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	4058	30	metabolites	metabolite	NNS
cord-001835-0s7ok4uw	4058	31	concentrations	concentration	NNS
cord-001835-0s7ok4uw	4058	32	.	.	.
cord-001835-0s7ok4uw	4059	1	Here	here	RB
cord-001835-0s7ok4uw	4059	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	4059	3	describe	describe	VBP
cord-001835-0s7ok4uw	4059	4	a	a	DT
cord-001835-0s7ok4uw	4059	5	totally	totally	RB
cord-001835-0s7ok4uw	4059	6	genetically	genetically	RB
cord-001835-0s7ok4uw	4059	7	encoded	encode	VBN
cord-001835-0s7ok4uw	4059	8	sensor	sensor	NN
cord-001835-0s7ok4uw	4059	9	based	base	VBN
cord-001835-0s7ok4uw	4059	10	on	on	IN
cord-001835-0s7ok4uw	4059	11	the	the	DT
cord-001835-0s7ok4uw	4059	12	Snifits	Snifits	NNP
cord-001835-0s7ok4uw	4059	13	modular	modular	JJ
cord-001835-0s7ok4uw	4059	14	design	design	NN
cord-001835-0s7ok4uw	4059	15	for	for	IN
cord-001835-0s7ok4uw	4059	16	the	the	DT
cord-001835-0s7ok4uw	4059	17	assessment	assessment	NN
cord-001835-0s7ok4uw	4059	18	of	of	IN
cord-001835-0s7ok4uw	4059	19	the	the	DT
cord-001835-0s7ok4uw	4059	20	cell	cell	NN
cord-001835-0s7ok4uw	4059	21	permeability	permeability	NN
cord-001835-0s7ok4uw	4059	22	of	of	IN
cord-001835-0s7ok4uw	4059	23	small	small	JJ
cord-001835-0s7ok4uw	4059	24	molecules	molecule	NNS
cord-001835-0s7ok4uw	4059	25	and	and	CC
cord-001835-0s7ok4uw	4059	26	peptides	peptide	NNS
cord-001835-0s7ok4uw	4059	27	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4059	28	of	of	IN
cord-001835-0s7ok4uw	4059	29	the	the	DT
cord-001835-0s7ok4uw	4059	30	protein	protein	NN
cord-001835-0s7ok4uw	4059	31	-	-	HYPH
cord-001835-0s7ok4uw	4059	32	protein	protein	NN
cord-001835-0s7ok4uw	4059	33	interaction	interaction	NN
cord-001835-0s7ok4uw	4059	34	between	between	IN
cord-001835-0s7ok4uw	4059	35	p53	p53	NN
cord-001835-0s7ok4uw	4059	36	and	and	CC
cord-001835-0s7ok4uw	4059	37	HDM2	HDM2	NNP
cord-001835-0s7ok4uw	4059	38	.	.	.
cord-001835-0s7ok4uw	4060	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4060	2	show	show	VBP
cord-001835-0s7ok4uw	4060	3	that	that	IN
cord-001835-0s7ok4uw	4060	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4060	5	sensor	sensor	NN
cord-001835-0s7ok4uw	4060	6	detects	detect	VBZ
cord-001835-0s7ok4uw	4060	7	the	the	DT
cord-001835-0s7ok4uw	4060	8	presence	presence	NN
cord-001835-0s7ok4uw	4060	9	of	of	IN
cord-001835-0s7ok4uw	4060	10	HDM2-binding	hdm2-binde	VBG
cord-001835-0s7ok4uw	4060	11	stapled	staple	VBN
cord-001835-0s7ok4uw	4060	12	peptides	peptide	NNS
cord-001835-0s7ok4uw	4060	13	in	in	IN
cord-001835-0s7ok4uw	4060	14	vitro	vitro	FW
cord-001835-0s7ok4uw	4060	15	,	,	,
cord-001835-0s7ok4uw	4060	16	and	and	CC
cord-001835-0s7ok4uw	4060	17	,	,	,
cord-001835-0s7ok4uw	4060	18	when	when	WRB
cord-001835-0s7ok4uw	4060	19	expressed	express	VBN
cord-001835-0s7ok4uw	4060	20	in	in	IN
cord-001835-0s7ok4uw	4060	21	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	4060	22	cells	cell	NNS
cord-001835-0s7ok4uw	4060	23	,	,	,
cord-001835-0s7ok4uw	4060	24	it	-PRON-	PRP
cord-001835-0s7ok4uw	4060	25	responds	respond	VBZ
cord-001835-0s7ok4uw	4060	26	to	to	IN
cord-001835-0s7ok4uw	4060	27	the	the	DT
cord-001835-0s7ok4uw	4060	28	perfusion	perfusion	NN
cord-001835-0s7ok4uw	4060	29	of	of	IN
cord-001835-0s7ok4uw	4060	30	the	the	DT
cord-001835-0s7ok4uw	4060	31	known	know	VBN
cord-001835-0s7ok4uw	4060	32	small	small	JJ
cord-001835-0s7ok4uw	4060	33	molecule	molecule	NN
cord-001835-0s7ok4uw	4060	34	HDM2	HDM2	NNP
cord-001835-0s7ok4uw	4060	35	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	4060	36	Nutlin-3a	Nutlin-3a	NNP
cord-001835-0s7ok4uw	4060	37	.	.	.
cord-001835-0s7ok4uw	4061	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	4061	2	,	,	,
cord-001835-0s7ok4uw	4061	3	experiments	experiment	NNS
cord-001835-0s7ok4uw	4061	4	made	make	VBN
cord-001835-0s7ok4uw	4061	5	with	with	IN
cord-001835-0s7ok4uw	4061	6	an	an	DT
cord-001835-0s7ok4uw	4061	7	automated	automated	JJ
cord-001835-0s7ok4uw	4061	8	microscope	microscope	NN
cord-001835-0s7ok4uw	4061	9	show	show	NN
cord-001835-0s7ok4uw	4061	10	that	that	IN
cord-001835-0s7ok4uw	4061	11	the	the	DT
cord-001835-0s7ok4uw	4061	12	sensor	sensor	NN
cord-001835-0s7ok4uw	4061	13	is	be	VBZ
cord-001835-0s7ok4uw	4061	14	suitable	suitable	JJ
cord-001835-0s7ok4uw	4061	15	for	for	IN
cord-001835-0s7ok4uw	4061	16	measuring	measure	VBG
cord-001835-0s7ok4uw	4061	17	and	and	CC
cord-001835-0s7ok4uw	4061	18	comparing	compare	VBG
cord-001835-0s7ok4uw	4061	19	the	the	DT
cord-001835-0s7ok4uw	4061	20	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	4061	21	of	of	IN
cord-001835-0s7ok4uw	4061	22	entry	entry	NN
cord-001835-0s7ok4uw	4061	23	of	of	IN
cord-001835-0s7ok4uw	4061	24	different	different	JJ
cord-001835-0s7ok4uw	4061	25	kinds	kind	NNS
cord-001835-0s7ok4uw	4061	26	of	of	IN
cord-001835-0s7ok4uw	4061	27	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4061	28	in	in	IN
cord-001835-0s7ok4uw	4061	29	the	the	DT
cord-001835-0s7ok4uw	4061	30	cytosol	cytosol	NN
cord-001835-0s7ok4uw	4061	31	of	of	IN
cord-001835-0s7ok4uw	4061	32	living	living	NN
cord-001835-0s7ok4uw	4061	33	cells	cell	NNS
cord-001835-0s7ok4uw	4061	34	.	.	.
cord-001835-0s7ok4uw	4062	1	In	in	IN
cord-001835-0s7ok4uw	4062	2	parallel	parallel	NN
cord-001835-0s7ok4uw	4062	3	,	,	,
cord-001835-0s7ok4uw	4062	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	4062	5	are	be	VBP
cord-001835-0s7ok4uw	4062	6	developing	develop	VBG
cord-001835-0s7ok4uw	4062	7	an	an	DT
cord-001835-0s7ok4uw	4062	8	HCAII	HCAII	NNP
cord-001835-0s7ok4uw	4062	9	-	-	HYPH
cord-001835-0s7ok4uw	4062	10	based	base	VBN
cord-001835-0s7ok4uw	4062	11	sensor	sensor	NN
cord-001835-0s7ok4uw	4062	12	protein	protein	NN
cord-001835-0s7ok4uw	4062	13	for	for	IN
cord-001835-0s7ok4uw	4062	14	the	the	DT
cord-001835-0s7ok4uw	4062	15	sensing	sensing	NN
cord-001835-0s7ok4uw	4062	16	of	of	IN
cord-001835-0s7ok4uw	4062	17	sulfonamides	sulfonamide	NNS
cord-001835-0s7ok4uw	4062	18	and	and	CC
cord-001835-0s7ok4uw	4062	19	eventually	eventually	RB
cord-001835-0s7ok4uw	4062	20	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4062	21	peptide	peptide	NN
cord-001835-0s7ok4uw	4062	22	derivatives	derivative	NNS
cord-001835-0s7ok4uw	4062	23	.	.	.
cord-001835-0s7ok4uw	4063	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4063	2	show	show	VBP
cord-001835-0s7ok4uw	4063	3	that	that	IN
cord-001835-0s7ok4uw	4063	4	the	the	DT
cord-001835-0s7ok4uw	4063	5	sensor	sensor	NN
cord-001835-0s7ok4uw	4063	6	responds	respond	VBZ
cord-001835-0s7ok4uw	4063	7	to	to	IN
cord-001835-0s7ok4uw	4063	8	the	the	DT
cord-001835-0s7ok4uw	4063	9	presence	presence	NN
cord-001835-0s7ok4uw	4063	10	of	of	IN
cord-001835-0s7ok4uw	4063	11	different	different	JJ
cord-001835-0s7ok4uw	4063	12	kinds	kind	NNS
cord-001835-0s7ok4uw	4063	13	of	of	IN
cord-001835-0s7ok4uw	4063	14	HCA	HCA	NNP
cord-001835-0s7ok4uw	4063	15	-	-	HYPH
cord-001835-0s7ok4uw	4063	16	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4063	17	in	in	IN
cord-001835-0s7ok4uw	4063	18	vitro	vitro	FW
cord-001835-0s7ok4uw	4063	19	and	and	CC
cord-001835-0s7ok4uw	4063	20	in	in	IN
cord-001835-0s7ok4uw	4063	21	perfusion	perfusion	NN
cord-001835-0s7ok4uw	4063	22	experiments	experiment	NNS
cord-001835-0s7ok4uw	4063	23	.	.	.
cord-001835-0s7ok4uw	4064	1	This	this	DT
cord-001835-0s7ok4uw	4064	2	second	second	JJ
cord-001835-0s7ok4uw	4064	3	sensor	sensor	NN
cord-001835-0s7ok4uw	4064	4	would	would	MD
cord-001835-0s7ok4uw	4064	5	broaden	broaden	VB
cord-001835-0s7ok4uw	4064	6	the	the	DT
cord-001835-0s7ok4uw	4064	7	range	range	NN
cord-001835-0s7ok4uw	4064	8	of	of	IN
cord-001835-0s7ok4uw	4064	9	molecules	molecule	NNS
cord-001835-0s7ok4uw	4064	10	and	and	CC
cord-001835-0s7ok4uw	4064	11	peptides	peptide	NNS
cord-001835-0s7ok4uw	4064	12	whose	whose	WP$
cord-001835-0s7ok4uw	4064	13	permeability	permeability	NN
cord-001835-0s7ok4uw	4064	14	can	can	MD
cord-001835-0s7ok4uw	4064	15	be	be	VB
cord-001835-0s7ok4uw	4064	16	studied	study	VBN
cord-001835-0s7ok4uw	4064	17	with	with	IN
cord-001835-0s7ok4uw	4064	18	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4064	19	tools	tool	NNS
cord-001835-0s7ok4uw	4064	20	beyond	beyond	IN
cord-001835-0s7ok4uw	4064	21	the	the	DT
cord-001835-0s7ok4uw	4064	22	family	family	NN
cord-001835-0s7ok4uw	4064	23	of	of	IN
cord-001835-0s7ok4uw	4064	24	the	the	DT
cord-001835-0s7ok4uw	4064	25	HDM2-binders	hdm2-binder	NNS
cord-001835-0s7ok4uw	4064	26	.	.	.
cord-001835-0s7ok4uw	4065	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4065	2	sensors	sensor	NNS
cord-001835-0s7ok4uw	4065	3	overcome	overcome	VBP
cord-001835-0s7ok4uw	4065	4	the	the	DT
cord-001835-0s7ok4uw	4065	5	limitations	limitation	NNS
cord-001835-0s7ok4uw	4065	6	of	of	IN
cord-001835-0s7ok4uw	4065	7	the	the	DT
cord-001835-0s7ok4uw	4065	8	already	already	RB
cord-001835-0s7ok4uw	4065	9	existing	exist	VBG
cord-001835-0s7ok4uw	4065	10	techniques	technique	NNS
cord-001835-0s7ok4uw	4065	11	for	for	IN
cord-001835-0s7ok4uw	4065	12	measurements	measurement	NNS
cord-001835-0s7ok4uw	4065	13	of	of	IN
cord-001835-0s7ok4uw	4065	14	permeability	permeability	NN
cord-001835-0s7ok4uw	4065	15	while	while	IN
cord-001835-0s7ok4uw	4065	16	offering	offer	VBG
cord-001835-0s7ok4uw	4065	17	a	a	DT
cord-001835-0s7ok4uw	4065	18	simultaneous	simultaneous	JJ
cord-001835-0s7ok4uw	4065	19	measurement	measurement	NN
cord-001835-0s7ok4uw	4065	20	of	of	IN
cord-001835-0s7ok4uw	4065	21	the	the	DT
cord-001835-0s7ok4uw	4065	22	cell	cell	NN
cord-001835-0s7ok4uw	4065	23	permeability	permeability	NN
cord-001835-0s7ok4uw	4065	24	and	and	CC
cord-001835-0s7ok4uw	4065	25	of	of	IN
cord-001835-0s7ok4uw	4065	26	the	the	DT
cord-001835-0s7ok4uw	4065	27	binding	binding	JJ
cord-001835-0s7ok4uw	4065	28	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4065	29	of	of	IN
cord-001835-0s7ok4uw	4065	30	small	small	JJ
cord-001835-0s7ok4uw	4065	31	molecules	molecule	NNS
cord-001835-0s7ok4uw	4065	32	and	and	CC
cord-001835-0s7ok4uw	4065	33	peptides	peptide	NNS
cord-001835-0s7ok4uw	4065	34	of	of	IN
cord-001835-0s7ok4uw	4065	35	interest	interest	NN
cord-001835-0s7ok4uw	4065	36	.	.	.
cord-001835-0s7ok4uw	4066	1	Archer	Archer	NNP
cord-001835-0s7ok4uw	4066	2	:	:	:
cord-001835-0s7ok4uw	4067	1	Predicting	predict	VBG
cord-001835-0s7ok4uw	4067	2	protein	protein	NN
cord-001835-0s7ok4uw	4067	3	function	function	NN
cord-001835-0s7ok4uw	4067	4	using	use	VBG
cord-001835-0s7ok4uw	4067	5	local	local	JJ
cord-001835-0s7ok4uw	4067	6	structural	structural	JJ
cord-001835-0s7ok4uw	4067	7	features	feature	NNS
cord-001835-0s7ok4uw	4067	8	.	.	.
cord-001835-0s7ok4uw	4068	1	A	a	DT
cord-001835-0s7ok4uw	4068	2	helpful	helpful	JJ
cord-001835-0s7ok4uw	4068	3	tool	tool	NN
cord-001835-0s7ok4uw	4068	4	for	for	IN
cord-001835-0s7ok4uw	4068	5	protein	protein	NN
cord-001835-0s7ok4uw	4068	6	redesign	redesign	NN
cord-001835-0s7ok4uw	4068	7	.	.	.
cord-001835-0s7ok4uw	4069	1	Jaume	Jaume	NNP
cord-001835-0s7ok4uw	4069	2	Bonet	Bonet	NNP
cord-001835-0s7ok4uw	4069	3	1	1	CD
cord-001835-0s7ok4uw	4069	4	,	,	,
cord-001835-0s7ok4uw	4069	5	Javier	Javier	NNP
cord-001835-0s7ok4uw	4069	6	Garcia	Garcia	NNP
cord-001835-0s7ok4uw	4069	7	-	-	HYPH
cord-001835-0s7ok4uw	4069	8	Garcia	Garcia	NNP
cord-001835-0s7ok4uw	4069	9	1	1	CD
cord-001835-0s7ok4uw	4069	10	,	,	,
cord-001835-0s7ok4uw	4069	11	Joan	Joan	NNP
cord-001835-0s7ok4uw	4069	12	Planas	Planas	NNP
cord-001835-0s7ok4uw	4069	13	-	-	HYPH
cord-001835-0s7ok4uw	4069	14	Iglesias	Iglesias	NNP
cord-001835-0s7ok4uw	4069	15	2	2	CD
cord-001835-0s7ok4uw	4069	16	,	,	,
cord-001835-0s7ok4uw	4069	17	Narcis	Narcis	NNP
cord-001835-0s7ok4uw	4069	18	Fernandez	Fernandez	NNP
cord-001835-0s7ok4uw	4069	19	-	-	HYPH
cord-001835-0s7ok4uw	4069	20	Fuentes	Fuentes	NNP
cord-001835-0s7ok4uw	4069	21	3	3	CD
cord-001835-0s7ok4uw	4069	22	,	,	,
cord-001835-0s7ok4uw	4069	23	Baldo	Baldo	NNP
cord-001835-0s7ok4uw	4069	24	Oliva	Oliva	NNP
cord-001835-0s7ok4uw	4069	25	1	1	CD
cord-001835-0s7ok4uw	4069	26	1	1	CD
cord-001835-0s7ok4uw	4069	27	Structural	Structural	NNP
cord-001835-0s7ok4uw	4069	28	Bioinformatics	Bioinformatics	NNPS
cord-001835-0s7ok4uw	4069	29	Lab	Lab	NNP
cord-001835-0s7ok4uw	4069	30	,	,	,
cord-001835-0s7ok4uw	4069	31	GRIB	GRIB	NNP
cord-001835-0s7ok4uw	4069	32	,	,	,
cord-001835-0s7ok4uw	4069	33	UPF	UPF	NNP
cord-001835-0s7ok4uw	4069	34	,	,	,
cord-001835-0s7ok4uw	4069	35	2	2	CD
cord-001835-0s7ok4uw	4069	36	Division	Division	NNP
cord-001835-0s7ok4uw	4069	37	of	of	IN
cord-001835-0s7ok4uw	4069	38	Metabolic	Metabolic	NNP
cord-001835-0s7ok4uw	4069	39	and	and	CC
cord-001835-0s7ok4uw	4069	40	Vascular	Vascular	NNP
cord-001835-0s7ok4uw	4069	41	Health	Health	NNP
cord-001835-0s7ok4uw	4069	42	,	,	,
cord-001835-0s7ok4uw	4069	43	University	University	NNP
cord-001835-0s7ok4uw	4069	44	of	of	IN
cord-001835-0s7ok4uw	4069	45	Warwick	Warwick	NNP
cord-001835-0s7ok4uw	4069	46	,	,	,
cord-001835-0s7ok4uw	4069	47	3	3	CD
cord-001835-0s7ok4uw	4069	48	 	 	_SP
cord-001835-0s7ok4uw	4069	49	The	the	DT
cord-001835-0s7ok4uw	4069	50	advance	advance	NN
cord-001835-0s7ok4uw	4069	51	of	of	IN
cord-001835-0s7ok4uw	4069	52	high	high	JJ
cord-001835-0s7ok4uw	4069	53	-	-	HYPH
cord-001835-0s7ok4uw	4069	54	throughput	throughput	NN
cord-001835-0s7ok4uw	4069	55	sequencing	sequencing	NN
cord-001835-0s7ok4uw	4069	56	methodologies	methodology	NNS
cord-001835-0s7ok4uw	4069	57	has	have	VBZ
cord-001835-0s7ok4uw	4069	58	led	lead	VBN
cord-001835-0s7ok4uw	4069	59	to	to	IN
cord-001835-0s7ok4uw	4069	60	an	an	DT
cord-001835-0s7ok4uw	4069	61	exponential	exponential	JJ
cord-001835-0s7ok4uw	4069	62	increase	increase	NN
cord-001835-0s7ok4uw	4069	63	of	of	IN
cord-001835-0s7ok4uw	4069	64	new	new	JJ
cord-001835-0s7ok4uw	4069	65	protein	protein	NN
cord-001835-0s7ok4uw	4069	66	sequences	sequence	NNS
cord-001835-0s7ok4uw	4069	67	,	,	,
cord-001835-0s7ok4uw	4069	68	a	a	DT
cord-001835-0s7ok4uw	4069	69	large	large	JJ
cord-001835-0s7ok4uw	4069	70	proportion	proportion	NN
cord-001835-0s7ok4uw	4069	71	of	of	IN
cord-001835-0s7ok4uw	4069	72	which	which	WDT
cord-001835-0s7ok4uw	4069	73	remain	remain	VBP
cord-001835-0s7ok4uw	4069	74	unannotated	unannotated	JJ
cord-001835-0s7ok4uw	4069	75	.	.	.
cord-001835-0s7ok4uw	4070	1	The	the	DT
cord-001835-0s7ok4uw	4070	2	gap	gap	NN
cord-001835-0s7ok4uw	4070	3	between	between	IN
cord-001835-0s7ok4uw	4070	4	the	the	DT
cord-001835-0s7ok4uw	4070	5	number	number	NN
cord-001835-0s7ok4uw	4070	6	of	of	IN
cord-001835-0s7ok4uw	4070	7	known	know	VBN
cord-001835-0s7ok4uw	4070	8	proteins	protein	NNS
cord-001835-0s7ok4uw	4070	9	and	and	CC
cord-001835-0s7ok4uw	4070	10	those	those	DT
cord-001835-0s7ok4uw	4070	11	with	with	IN
cord-001835-0s7ok4uw	4070	12	assigned	assigned	JJ
cord-001835-0s7ok4uw	4070	13	function	function	NN
cord-001835-0s7ok4uw	4070	14	is	be	VBZ
cord-001835-0s7ok4uw	4070	15	increasing	increase	VBG
cord-001835-0s7ok4uw	4070	16	.	.	.
cord-001835-0s7ok4uw	4071	1	In	in	IN
cord-001835-0s7ok4uw	4071	2	light	light	NN
cord-001835-0s7ok4uw	4071	3	of	of	IN
cord-001835-0s7ok4uw	4071	4	this	this	DT
cord-001835-0s7ok4uw	4071	5	situation	situation	NN
cord-001835-0s7ok4uw	4071	6	,	,	,
cord-001835-0s7ok4uw	4071	7	computational	computational	JJ
cord-001835-0s7ok4uw	4071	8	methods	method	NNS
cord-001835-0s7ok4uw	4071	9	to	to	TO
cord-001835-0s7ok4uw	4071	10	predict	predict	VB
cord-001835-0s7ok4uw	4071	11	the	the	DT
cord-001835-0s7ok4uw	4071	12	function	function	NN
cord-001835-0s7ok4uw	4071	13	of	of	IN
cord-001835-0s7ok4uw	4071	14	proteins	protein	NNS
cord-001835-0s7ok4uw	4071	15	have	have	VBP
cord-001835-0s7ok4uw	4071	16	become	become	VBN
cord-001835-0s7ok4uw	4071	17	a	a	DT
cord-001835-0s7ok4uw	4071	18	valid	valid	JJ
cord-001835-0s7ok4uw	4071	19	and	and	CC
cord-001835-0s7ok4uw	4071	20	necessary	necessary	JJ
cord-001835-0s7ok4uw	4071	21	strategy	strategy	NN
cord-001835-0s7ok4uw	4071	22	.	.	.
cord-001835-0s7ok4uw	4072	1	Here	here	RB
cord-001835-0s7ok4uw	4072	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	4072	3	present	present	VBP
cord-001835-0s7ok4uw	4072	4	Archer	Archer	NNP
cord-001835-0s7ok4uw	4072	5	,	,	,
cord-001835-0s7ok4uw	4072	6	a	a	DT
cord-001835-0s7ok4uw	4072	7	server	server	NN
cord-001835-0s7ok4uw	4072	8	that	that	WDT
cord-001835-0s7ok4uw	4072	9	exploits	exploit	VBZ
cord-001835-0s7ok4uw	4072	10	ArchDB	ArchDB	NNP
cord-001835-0s7ok4uw	4072	11	's	's	POS
cord-001835-0s7ok4uw	4072	12	hierarchy	hierarchy	NN
cord-001835-0s7ok4uw	4072	13	of	of	IN
cord-001835-0s7ok4uw	4072	14	super	super	JJ
cord-001835-0s7ok4uw	4072	15	-	-	JJ
cord-001835-0s7ok4uw	4072	16	secondary	secondary	JJ
cord-001835-0s7ok4uw	4072	17	structures	structure	NNS
cord-001835-0s7ok4uw	4072	18	to	to	TO
cord-001835-0s7ok4uw	4072	19	map	map	VB
cord-001835-0s7ok4uw	4072	20	GO	GO	NNP
cord-001835-0s7ok4uw	4072	21	and	and	CC
cord-001835-0s7ok4uw	4072	22	Enzyme	Enzyme	NNP
cord-001835-0s7ok4uw	4072	23	functions	function	NNS
cord-001835-0s7ok4uw	4072	24	upon	upon	IN
cord-001835-0s7ok4uw	4072	25	protein	protein	NN
cord-001835-0s7ok4uw	4072	26	regions	region	NNS
cord-001835-0s7ok4uw	4072	27	and	and	CC
cord-001835-0s7ok4uw	4072	28	,	,	,
cord-001835-0s7ok4uw	4072	29	thus	thus	RB
cord-001835-0s7ok4uw	4072	30	,	,	,
cord-001835-0s7ok4uw	4072	31	infer	infer	VB
cord-001835-0s7ok4uw	4072	32	the	the	DT
cord-001835-0s7ok4uw	4072	33	function	function	NN
cord-001835-0s7ok4uw	4072	34	of	of	IN
cord-001835-0s7ok4uw	4072	35	a	a	DT
cord-001835-0s7ok4uw	4072	36	protein	protein	NN
cord-001835-0s7ok4uw	4072	37	.	.	.
cord-001835-0s7ok4uw	4073	1	The	the	DT
cord-001835-0s7ok4uw	4073	2	server	server	NN
cord-001835-0s7ok4uw	4073	3	relies	rely	VBZ
cord-001835-0s7ok4uw	4073	4	on	on	IN
cord-001835-0s7ok4uw	4073	5	either	either	CC
cord-001835-0s7ok4uw	4073	6	the	the	DT
cord-001835-0s7ok4uw	4073	7	sequence	sequence	NN
cord-001835-0s7ok4uw	4073	8	or	or	CC
cord-001835-0s7ok4uw	4073	9	structure	structure	NN
cord-001835-0s7ok4uw	4073	10	of	of	IN
cord-001835-0s7ok4uw	4073	11	the	the	DT
cord-001835-0s7ok4uw	4073	12	protein	protein	NN
cord-001835-0s7ok4uw	4073	13	of	of	IN
cord-001835-0s7ok4uw	4073	14	interest	interest	NN
cord-001835-0s7ok4uw	4073	15	and	and	CC
cord-001835-0s7ok4uw	4073	16	returns	return	VBZ
cord-001835-0s7ok4uw	4073	17	the	the	DT
cord-001835-0s7ok4uw	4073	18	mapping	mapping	NN
cord-001835-0s7ok4uw	4073	19	of	of	IN
cord-001835-0s7ok4uw	4073	20	functional	functional	JJ
cord-001835-0s7ok4uw	4073	21	subclasses	subclass	NNS
cord-001835-0s7ok4uw	4073	22	extracted	extract	VBN
cord-001835-0s7ok4uw	4073	23	from	from	IN
cord-001835-0s7ok4uw	4073	24	ArchDB	ArchDB	NNP
cord-001835-0s7ok4uw	4073	25	.	.	.
cord-001835-0s7ok4uw	4074	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	4074	2	,	,	,
cord-001835-0s7ok4uw	4074	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	4074	4	computes	compute	VBZ
cord-001835-0s7ok4uw	4074	5	the	the	DT
cord-001835-0s7ok4uw	4074	6	functional	functional	JJ
cord-001835-0s7ok4uw	4074	7	enrichment	enrichment	NN
cord-001835-0s7ok4uw	4074	8	and	and	CC
cord-001835-0s7ok4uw	4074	9	significance	significance	NN
cord-001835-0s7ok4uw	4074	10	of	of	IN
cord-001835-0s7ok4uw	4074	11	each	each	DT
cord-001835-0s7ok4uw	4074	12	subclass	subclass	NN
cord-001835-0s7ok4uw	4074	13	,	,	,
cord-001835-0s7ok4uw	4074	14	combines	combine	VBZ
cord-001835-0s7ok4uw	4074	15	the	the	DT
cord-001835-0s7ok4uw	4074	16	functional	functional	JJ
cord-001835-0s7ok4uw	4074	17	descriptors	descriptor	NNS
cord-001835-0s7ok4uw	4074	18	and	and	CC
cord-001835-0s7ok4uw	4074	19	predicts	predict	VBZ
cord-001835-0s7ok4uw	4074	20	the	the	DT
cord-001835-0s7ok4uw	4074	21	function	function	NN
cord-001835-0s7ok4uw	4074	22	of	of	IN
cord-001835-0s7ok4uw	4074	23	the	the	DT
cord-001835-0s7ok4uw	4074	24	query	query	NN
cord-001835-0s7ok4uw	4074	25	-	-	HYPH
cord-001835-0s7ok4uw	4074	26	protein	protein	NN
cord-001835-0s7ok4uw	4074	27	.	.	.
cord-001835-0s7ok4uw	4075	1	Combining	combine	VBG
cord-001835-0s7ok4uw	4075	2	the	the	DT
cord-001835-0s7ok4uw	4075	3	functional	functional	JJ
cord-001835-0s7ok4uw	4075	4	enrichment	enrichment	NN
cord-001835-0s7ok4uw	4075	5	analysis	analysis	NN
cord-001835-0s7ok4uw	4075	6	of	of	IN
cord-001835-0s7ok4uw	4075	7	the	the	DT
cord-001835-0s7ok4uw	4075	8	super	super	JJ
cord-001835-0s7ok4uw	4075	9	-	-	JJ
cord-001835-0s7ok4uw	4075	10	secondary	secondary	JJ
cord-001835-0s7ok4uw	4075	11	structures	structure	NNS
cord-001835-0s7ok4uw	4075	12	with	with	IN
cord-001835-0s7ok4uw	4075	13	the	the	DT
cord-001835-0s7ok4uw	4075	14	structural	structural	JJ
cord-001835-0s7ok4uw	4075	15	classification	classification	NN
cord-001835-0s7ok4uw	4075	16	of	of	IN
cord-001835-0s7ok4uw	4075	17	ArchDB	ArchDB	NNP
cord-001835-0s7ok4uw	4075	18	,	,	,
cord-001835-0s7ok4uw	4075	19	users	user	NNS
cord-001835-0s7ok4uw	4075	20	can	can	MD
cord-001835-0s7ok4uw	4075	21	select	select	VB
cord-001835-0s7ok4uw	4075	22	variants	variant	NNS
cord-001835-0s7ok4uw	4075	23	of	of	IN
cord-001835-0s7ok4uw	4075	24	the	the	DT
cord-001835-0s7ok4uw	4075	25	target	target	NN
cord-001835-0s7ok4uw	4075	26	sequence	sequence	NN
cord-001835-0s7ok4uw	4075	27	that	that	WDT
cord-001835-0s7ok4uw	4075	28	swap	swap	VBP
cord-001835-0s7ok4uw	4075	29	the	the	DT
cord-001835-0s7ok4uw	4075	30	region	region	NN
cord-001835-0s7ok4uw	4075	31	of	of	IN
cord-001835-0s7ok4uw	4075	32	a	a	DT
cord-001835-0s7ok4uw	4075	33	supersecondary	supersecondary	JJ
cord-001835-0s7ok4uw	4075	34	structure	structure	NN
cord-001835-0s7ok4uw	4075	35	by	by	IN
cord-001835-0s7ok4uw	4075	36	another	another	DT
cord-001835-0s7ok4uw	4075	37	that	that	WDT
cord-001835-0s7ok4uw	4075	38	putatively	putatively	RB
cord-001835-0s7ok4uw	4075	39	fits	fit	VBZ
cord-001835-0s7ok4uw	4075	40	in	in	IN
cord-001835-0s7ok4uw	4075	41	the	the	DT
cord-001835-0s7ok4uw	4075	42	same	same	JJ
cord-001835-0s7ok4uw	4075	43	scaffold	scaffold	NN
cord-001835-0s7ok4uw	4075	44	minimizing	minimize	VBG
cord-001835-0s7ok4uw	4075	45	the	the	DT
cord-001835-0s7ok4uw	4075	46	effect	effect	NN
cord-001835-0s7ok4uw	4075	47	on	on	IN
cord-001835-0s7ok4uw	4075	48	the	the	DT
cord-001835-0s7ok4uw	4075	49	global	global	JJ
cord-001835-0s7ok4uw	4075	50	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	4075	51	structure	structure	NN
cord-001835-0s7ok4uw	4075	52	.	.	.
cord-001835-0s7ok4uw	4076	1	Only	only	RB
cord-001835-0s7ok4uw	4076	2	variants	variant	NNS
cord-001835-0s7ok4uw	4076	3	that	that	WDT
cord-001835-0s7ok4uw	4076	4	modify	modify	VBP
cord-001835-0s7ok4uw	4076	5	the	the	DT
cord-001835-0s7ok4uw	4076	6	predicted	predict	VBN
cord-001835-0s7ok4uw	4076	7	function	function	NN
cord-001835-0s7ok4uw	4076	8	are	be	VBP
cord-001835-0s7ok4uw	4076	9	offered	offer	VBN
cord-001835-0s7ok4uw	4076	10	for	for	IN
cord-001835-0s7ok4uw	4076	11	selection	selection	NN
cord-001835-0s7ok4uw	4076	12	,	,	,
cord-001835-0s7ok4uw	4076	13	thus	thus	RB
cord-001835-0s7ok4uw	4076	14	providing	provide	VBG
cord-001835-0s7ok4uw	4076	15	a	a	DT
cord-001835-0s7ok4uw	4076	16	rational	rational	JJ
cord-001835-0s7ok4uw	4076	17	,	,	,
cord-001835-0s7ok4uw	4076	18	knowledge	knowledge	NN
cord-001835-0s7ok4uw	4076	19	-	-	HYPH
cord-001835-0s7ok4uw	4076	20	based	base	VBN
cord-001835-0s7ok4uw	4076	21	,	,	,
cord-001835-0s7ok4uw	4076	22	approach	approach	NN
cord-001835-0s7ok4uw	4076	23	for	for	IN
cord-001835-0s7ok4uw	4076	24	protein	protein	NN
cord-001835-0s7ok4uw	4076	25	design	design	NN
cord-001835-0s7ok4uw	4076	26	and	and	CC
cord-001835-0s7ok4uw	4076	27	functionalization	functionalization	NN
cord-001835-0s7ok4uw	4076	28	.	.	.
cord-001835-0s7ok4uw	4077	1	The	the	DT
cord-001835-0s7ok4uw	4077	2	Archer	Archer	NNP
cord-001835-0s7ok4uw	4077	3	server	server	NN
cord-001835-0s7ok4uw	4077	4	is	be	VBZ
cord-001835-0s7ok4uw	4077	5	accessible	accessible	JJ
cord-001835-0s7ok4uw	4077	6	at	at	IN
cord-001835-0s7ok4uw	4077	7	http://sbi.imim.es/archer	http://sbi.imim.es/archer	NNP
cord-001835-0s7ok4uw	4077	8	.	.	.
cord-001835-0s7ok4uw	4078	1	Phytochromes	phytochrome	NNS
cord-001835-0s7ok4uw	4078	2	are	be	VBP
cord-001835-0s7ok4uw	4078	3	natural	natural	JJ
cord-001835-0s7ok4uw	4078	4	photoreceptors	photoreceptor	NNS
cord-001835-0s7ok4uw	4078	5	known	know	VBN
cord-001835-0s7ok4uw	4078	6	to	to	TO
cord-001835-0s7ok4uw	4078	7	regulate	regulate	VB
cord-001835-0s7ok4uw	4078	8	photosynthesis	photosynthesis	NN
cord-001835-0s7ok4uw	4078	9	in	in	IN
cord-001835-0s7ok4uw	4078	10	plants	plant	NNS
cord-001835-0s7ok4uw	4078	11	,	,	,
cord-001835-0s7ok4uw	4078	12	fungi	fungus	NNS
cord-001835-0s7ok4uw	4078	13	and	and	CC
cord-001835-0s7ok4uw	4078	14	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	4078	15	.	.	.
cord-001835-0s7ok4uw	4079	1	Phytochromes	phytochrome	NNS
cord-001835-0s7ok4uw	4079	2	found	find	VBN
cord-001835-0s7ok4uw	4079	3	in	in	IN
cord-001835-0s7ok4uw	4079	4	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	4079	5	share	share	VBP
cord-001835-0s7ok4uw	4079	6	common	common	JJ
cord-001835-0s7ok4uw	4079	7	architecture	architecture	NN
cord-001835-0s7ok4uw	4079	8	and	and	CC
cord-001835-0s7ok4uw	4079	9	consist	consist	VBP
cord-001835-0s7ok4uw	4079	10	of	of	IN
cord-001835-0s7ok4uw	4079	11	a	a	DT
cord-001835-0s7ok4uw	4079	12	PAS	pas	NN
cord-001835-0s7ok4uw	4079	13	-	-	HYPH
cord-001835-0s7ok4uw	4079	14	GAF	GAF	NNP
cord-001835-0s7ok4uw	4079	15	-	-	HYPH
cord-001835-0s7ok4uw	4079	16	PHY	PHY	NNP
cord-001835-0s7ok4uw	4079	17	photosensory	photosensory	NNP
cord-001835-0s7ok4uw	4079	18	core	core	NN
cord-001835-0s7ok4uw	4079	19	and	and	CC
cord-001835-0s7ok4uw	4079	20	a	a	DT
cord-001835-0s7ok4uw	4079	21	C	c	NN
cord-001835-0s7ok4uw	4079	22	-	-	HYPH
cord-001835-0s7ok4uw	4079	23	terminal	terminal	NN
cord-001835-0s7ok4uw	4079	24	output	output	NN
cord-001835-0s7ok4uw	4079	25	module	module	NN
cord-001835-0s7ok4uw	4079	26	,	,	,
cord-001835-0s7ok4uw	4079	27	responsible	responsible	JJ
cord-001835-0s7ok4uw	4079	28	for	for	IN
cord-001835-0s7ok4uw	4079	29	biological	biological	JJ
cord-001835-0s7ok4uw	4079	30	function	function	NN
cord-001835-0s7ok4uw	4079	31	.	.	.
cord-001835-0s7ok4uw	4080	1	A	a	DT
cord-001835-0s7ok4uw	4080	2	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	4080	3	phytochrome	phytochrome	NN
cord-001835-0s7ok4uw	4080	4	,	,	,
cord-001835-0s7ok4uw	4080	5	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4080	6	,	,	,
cord-001835-0s7ok4uw	4080	7	from	from	IN
cord-001835-0s7ok4uw	4080	8	Rhodopseudomonas	Rhodopseudomonas	NNP
cord-001835-0s7ok4uw	4080	9	palustris	palustris	NN
cord-001835-0s7ok4uw	4080	10	undergoes	undergo	VBZ
cord-001835-0s7ok4uw	4080	11	reversible	reversible	JJ
cord-001835-0s7ok4uw	4080	12	conversion	conversion	NN
cord-001835-0s7ok4uw	4080	13	from	from	IN
cord-001835-0s7ok4uw	4080	14	the	the	DT
cord-001835-0s7ok4uw	4080	15	farred	farre	VBN
cord-001835-0s7ok4uw	4080	16	absorbing	absorb	VBG
cord-001835-0s7ok4uw	4080	17	state	state	NN
cord-001835-0s7ok4uw	4080	18	(	(	-LRB-
cord-001835-0s7ok4uw	4080	19	Pfr	Pfr	NNP
cord-001835-0s7ok4uw	4080	20	)	)	-RRB-
cord-001835-0s7ok4uw	4080	21	to	to	IN
cord-001835-0s7ok4uw	4080	22	the	the	DT
cord-001835-0s7ok4uw	4080	23	red	red	JJ
cord-001835-0s7ok4uw	4080	24	-	-	HYPH
cord-001835-0s7ok4uw	4080	25	absorbing	absorb	VBG
cord-001835-0s7ok4uw	4080	26	state	state	NN
cord-001835-0s7ok4uw	4080	27	(	(	-LRB-
cord-001835-0s7ok4uw	4080	28	Pr	Pr	NNP
cord-001835-0s7ok4uw	4080	29	)	)	-RRB-
cord-001835-0s7ok4uw	4080	30	followed	follow	VBN
cord-001835-0s7ok4uw	4080	31	by	by	IN
cord-001835-0s7ok4uw	4080	32	the	the	DT
cord-001835-0s7ok4uw	4080	33	conformational	conformational	JJ
cord-001835-0s7ok4uw	4080	34	change	change	NN
cord-001835-0s7ok4uw	4080	35	upon	upon	IN
cord-001835-0s7ok4uw	4080	36	740	740	CD
cord-001835-0s7ok4uw	4080	37	nm	nm	NN
cord-001835-0s7ok4uw	4080	38	light	light	JJ
cord-001835-0s7ok4uw	4080	39	irradiation	irradiation	NN
cord-001835-0s7ok4uw	4080	40	.	.	.
cord-001835-0s7ok4uw	4081	1	As	as	IN
cord-001835-0s7ok4uw	4081	2	most	most	JJS
cord-001835-0s7ok4uw	4081	3	of	of	IN
cord-001835-0s7ok4uw	4081	4	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	4081	5	phytochromes	phytochrome	NNS
cord-001835-0s7ok4uw	4081	6	,	,	,
cord-001835-0s7ok4uw	4081	7	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4081	8	forms	form	VBZ
cord-001835-0s7ok4uw	4081	9	a	a	DT
cord-001835-0s7ok4uw	4081	10	dimer	dimer	NN
cord-001835-0s7ok4uw	4081	11	.	.	.
cord-001835-0s7ok4uw	4082	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4082	2	was	be	VBD
cord-001835-0s7ok4uw	4082	3	shown	show	VBN
cord-001835-0s7ok4uw	4082	4	that	that	IN
cord-001835-0s7ok4uw	4082	5	740	740	CD
cord-001835-0s7ok4uw	4082	6	nm	nm	NN
cord-001835-0s7ok4uw	4082	7	light	light	NN
cord-001835-0s7ok4uw	4082	8	causes	cause	VBZ
cord-001835-0s7ok4uw	4082	9	a	a	DT
cord-001835-0s7ok4uw	4082	10	protomer	protomer	NN
cord-001835-0s7ok4uw	4082	11	swapping	swapping	NN
cord-001835-0s7ok4uw	4082	12	between	between	IN
cord-001835-0s7ok4uw	4082	13	the	the	DT
cord-001835-0s7ok4uw	4082	14	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4082	15	dimers	dimer	NNS
cord-001835-0s7ok4uw	4082	16	;	;	:
cord-001835-0s7ok4uw	4082	17	and	and	CC
cord-001835-0s7ok4uw	4082	18	likely	likely	RB
cord-001835-0s7ok4uw	4082	19	,	,	,
cord-001835-0s7ok4uw	4082	20	the	the	DT
cord-001835-0s7ok4uw	4082	21	output	output	NN
cord-001835-0s7ok4uw	4082	22	module	module	NN
cord-001835-0s7ok4uw	4082	23	is	be	VBZ
cord-001835-0s7ok4uw	4082	24	involved	involve	VBN
cord-001835-0s7ok4uw	4082	25	in	in	IN
cord-001835-0s7ok4uw	4082	26	this	this	DT
cord-001835-0s7ok4uw	4082	27	process	process	NN
cord-001835-0s7ok4uw	4082	28	.	.	.
cord-001835-0s7ok4uw	4083	1	However	however	RB
cord-001835-0s7ok4uw	4083	2	,	,	,
cord-001835-0s7ok4uw	4083	3	the	the	DT
cord-001835-0s7ok4uw	4083	4	mechanism	mechanism	NN
cord-001835-0s7ok4uw	4083	5	of	of	IN
cord-001835-0s7ok4uw	4083	6	the	the	DT
cord-001835-0s7ok4uw	4083	7	light	light	NN
cord-001835-0s7ok4uw	4083	8	-	-	HYPH
cord-001835-0s7ok4uw	4083	9	induced	induce	VBN
cord-001835-0s7ok4uw	4083	10	swapping	swapping	NN
cord-001835-0s7ok4uw	4083	11	is	be	VBZ
cord-001835-0s7ok4uw	4083	12	poorly	poorly	RB
cord-001835-0s7ok4uw	4083	13	studied	study	VBN
cord-001835-0s7ok4uw	4083	14	.	.	.
cord-001835-0s7ok4uw	4084	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4084	2	tested	test	VBD
cord-001835-0s7ok4uw	4084	3	an	an	DT
cord-001835-0s7ok4uw	4084	4	ability	ability	NN
cord-001835-0s7ok4uw	4084	5	of	of	IN
cord-001835-0s7ok4uw	4084	6	the	the	DT
cord-001835-0s7ok4uw	4084	7	protomer	protomer	NN
cord-001835-0s7ok4uw	4084	8	swapping	swapping	NN
cord-001835-0s7ok4uw	4084	9	between	between	IN
cord-001835-0s7ok4uw	4084	10	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4084	11	dimers	dimer	NNS
cord-001835-0s7ok4uw	4084	12	using	use	VBG
cord-001835-0s7ok4uw	4084	13	pull	pull	VB
cord-001835-0s7ok4uw	4084	14	-	-	HYPH
cord-001835-0s7ok4uw	4084	15	down	down	RP
cord-001835-0s7ok4uw	4084	16	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	4084	17	assay	assay	NN
cord-001835-0s7ok4uw	4084	18	.	.	.
cord-001835-0s7ok4uw	4085	1	For	for	IN
cord-001835-0s7ok4uw	4085	2	this	this	DT
cord-001835-0s7ok4uw	4085	3	,	,	,
cord-001835-0s7ok4uw	4085	4	strep	strep	NN
cord-001835-0s7ok4uw	4085	5	-	-	HYPH
cord-001835-0s7ok4uw	4085	6	tagged	tagged	NNP
cord-001835-0s7ok4uw	4085	7	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4085	8	was	be	VBD
cord-001835-0s7ok4uw	4085	9	immobilized	immobilize	VBN
cord-001835-0s7ok4uw	4085	10	on	on	IN
cord-001835-0s7ok4uw	4085	11	Strep	Strep	NNP
cord-001835-0s7ok4uw	4085	12	-	-	HYPH
cord-001835-0s7ok4uw	4085	13	Tactin	Tactin	NNP
cord-001835-0s7ok4uw	4085	14	sepharose	sepharose	JJ
cord-001835-0s7ok4uw	4085	15	beads	bead	NNS
cord-001835-0s7ok4uw	4085	16	in	in	IN
cord-001835-0s7ok4uw	4085	17	the	the	DT
cord-001835-0s7ok4uw	4085	18	presence	presence	NN
cord-001835-0s7ok4uw	4085	19	of	of	IN
cord-001835-0s7ok4uw	4085	20	untagged	untagged	NNP
cord-001835-0s7ok4uw	4085	21	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4085	22	fused	fuse	VBN
cord-001835-0s7ok4uw	4085	23	to	to	IN
cord-001835-0s7ok4uw	4085	24	mRuby2	mRuby2	NNP
cord-001835-0s7ok4uw	4085	25	at	at	IN
cord-001835-0s7ok4uw	4085	26	different	different	JJ
cord-001835-0s7ok4uw	4085	27	concentrations	concentration	NNS
cord-001835-0s7ok4uw	4085	28	.	.	.
cord-001835-0s7ok4uw	4086	1	After	after	IN
cord-001835-0s7ok4uw	4086	2	incubation	incubation	NN
cord-001835-0s7ok4uw	4086	3	,	,	,
cord-001835-0s7ok4uw	4086	4	the	the	DT
cord-001835-0s7ok4uw	4086	5	proteins	protein	NNS
cord-001835-0s7ok4uw	4086	6	were	be	VBD
cord-001835-0s7ok4uw	4086	7	eluted	elute	VBN
cord-001835-0s7ok4uw	4086	8	and	and	CC
cord-001835-0s7ok4uw	4086	9	visualized	visualize	VBN
cord-001835-0s7ok4uw	4086	10	in	in	IN
cord-001835-0s7ok4uw	4086	11	SDS	SDS	NNP
cord-001835-0s7ok4uw	4086	12	-	-	HYPH
cord-001835-0s7ok4uw	4086	13	gel	gel	NN
cord-001835-0s7ok4uw	4086	14	using	use	VBG
cord-001835-0s7ok4uw	4086	15	a	a	DT
cord-001835-0s7ok4uw	4086	16	zinc	zinc	NN
cord-001835-0s7ok4uw	4086	17	-	-	HYPH
cord-001835-0s7ok4uw	4086	18	induced	induce	VBN
cord-001835-0s7ok4uw	4086	19	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	4086	20	assay	assay	NN
cord-001835-0s7ok4uw	4086	21	.	.	.
cord-001835-0s7ok4uw	4087	1	An	an	DT
cord-001835-0s7ok4uw	4087	2	amount	amount	NN
cord-001835-0s7ok4uw	4087	3	of	of	IN
cord-001835-0s7ok4uw	4087	4	the	the	DT
cord-001835-0s7ok4uw	4087	5	bound	bind	VBN
cord-001835-0s7ok4uw	4087	6	to	to	IN
cord-001835-0s7ok4uw	4087	7	beads	bead	NNS
cord-001835-0s7ok4uw	4087	8	protein	protein	NN
cord-001835-0s7ok4uw	4087	9	was	be	VBD
cord-001835-0s7ok4uw	4087	10	estimated	estimate	VBN
cord-001835-0s7ok4uw	4087	11	by	by	IN
cord-001835-0s7ok4uw	4087	12	densitometry	densitometry	NNP
cord-001835-0s7ok4uw	4087	13	.	.	.
cord-001835-0s7ok4uw	4088	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4088	2	was	be	VBD
cord-001835-0s7ok4uw	4088	3	found	find	VBN
cord-001835-0s7ok4uw	4088	4	that	that	IN
cord-001835-0s7ok4uw	4088	5	more	more	JJR
cord-001835-0s7ok4uw	4088	6	than	than	IN
cord-001835-0s7ok4uw	4088	7	75	75	CD
cord-001835-0s7ok4uw	4088	8	%	%	NN
cord-001835-0s7ok4uw	4088	9	of	of	IN
cord-001835-0s7ok4uw	4088	10	heterodimers	heterodimer	NNS
cord-001835-0s7ok4uw	4088	11	(	(	-LRB-
cord-001835-0s7ok4uw	4088	12	streptagged	streptagged	NNP
cord-001835-0s7ok4uw	4088	13	-	-	HYPH
cord-001835-0s7ok4uw	4088	14	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4088	15	and	and	CC
cord-001835-0s7ok4uw	4088	16	BphP1-mRuby2	BphP1-mRuby2	NNP
cord-001835-0s7ok4uw	4088	17	)	)	-RRB-
cord-001835-0s7ok4uw	4088	18	form	form	NN
cord-001835-0s7ok4uw	4088	19	within	within	IN
cord-001835-0s7ok4uw	4088	20	2.5	2.5	CD
cord-001835-0s7ok4uw	4088	21	h	h	NN
cord-001835-0s7ok4uw	4088	22	of	of	IN
cord-001835-0s7ok4uw	4088	23	incubation	incubation	NN
cord-001835-0s7ok4uw	4088	24	under	under	IN
cord-001835-0s7ok4uw	4088	25	740	740	CD
cord-001835-0s7ok4uw	4088	26	nm	nm	NN
cord-001835-0s7ok4uw	4088	27	light	light	NN
cord-001835-0s7ok4uw	4088	28	at	at	IN
cord-001835-0s7ok4uw	4088	29	8-fold	8-fold	CD
cord-001835-0s7ok4uw	4088	30	excess	excess	NN
cord-001835-0s7ok4uw	4088	31	of	of	IN
cord-001835-0s7ok4uw	4088	32	one	one	CD
cord-001835-0s7ok4uw	4088	33	of	of	IN
cord-001835-0s7ok4uw	4088	34	the	the	DT
cord-001835-0s7ok4uw	4088	35	interacting	interact	VBG
cord-001835-0s7ok4uw	4088	36	partners	partner	NNS
cord-001835-0s7ok4uw	4088	37	.	.	.
cord-001835-0s7ok4uw	4089	1	In	in	IN
cord-001835-0s7ok4uw	4089	2	darkness	darkness	NN
cord-001835-0s7ok4uw	4089	3	,	,	,
cord-001835-0s7ok4uw	4089	4	the	the	DT
cord-001835-0s7ok4uw	4089	5	swapping	swapping	NN
cord-001835-0s7ok4uw	4089	6	was	be	VBD
cord-001835-0s7ok4uw	4089	7	much	much	RB
cord-001835-0s7ok4uw	4089	8	slower	slow	JJR
cord-001835-0s7ok4uw	4089	9	.	.	.
cord-001835-0s7ok4uw	4090	1	In	in	IN
cord-001835-0s7ok4uw	4090	2	the	the	DT
cord-001835-0s7ok4uw	4090	3	similar	similar	JJ
cord-001835-0s7ok4uw	4090	4	setup	setup	NN
cord-001835-0s7ok4uw	4090	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4090	6	checked	check	VBD
cord-001835-0s7ok4uw	4090	7	the	the	DT
cord-001835-0s7ok4uw	4090	8	amount	amount	NN
cord-001835-0s7ok4uw	4090	9	of	of	IN
cord-001835-0s7ok4uw	4090	10	heterodimers	heterodimer	NNS
cord-001835-0s7ok4uw	4090	11	after	after	IN
cord-001835-0s7ok4uw	4090	12	15	15	CD
cord-001835-0s7ok4uw	4090	13	,	,	,
cord-001835-0s7ok4uw	4090	14	30	30	CD
cord-001835-0s7ok4uw	4090	15	and	and	CC
cord-001835-0s7ok4uw	4090	16	120	120	CD
cord-001835-0s7ok4uw	4090	17	min	min	NN
cord-001835-0s7ok4uw	4090	18	of	of	IN
cord-001835-0s7ok4uw	4090	19	incubation	incubation	NN
cord-001835-0s7ok4uw	4090	20	.	.	.
cord-001835-0s7ok4uw	4091	1	No	no	DT
cord-001835-0s7ok4uw	4091	2	difference	difference	NN
cord-001835-0s7ok4uw	4091	3	was	be	VBD
cord-001835-0s7ok4uw	4091	4	observed	observe	VBN
cord-001835-0s7ok4uw	4091	5	for	for	IN
cord-001835-0s7ok4uw	4091	6	different	different	JJ
cord-001835-0s7ok4uw	4091	7	time	time	NN
cord-001835-0s7ok4uw	4091	8	points	point	NNS
cord-001835-0s7ok4uw	4091	9	,	,	,
cord-001835-0s7ok4uw	4091	10	suggesting	suggest	VBG
cord-001835-0s7ok4uw	4091	11	that	that	IN
cord-001835-0s7ok4uw	4091	12	the	the	DT
cord-001835-0s7ok4uw	4091	13	protomer	protomer	NN
cord-001835-0s7ok4uw	4091	14	swapping	swapping	NN
cord-001835-0s7ok4uw	4091	15	is	be	VBZ
cord-001835-0s7ok4uw	4091	16	relatively	relatively	RB
cord-001835-0s7ok4uw	4091	17	fast	fast	JJ
cord-001835-0s7ok4uw	4091	18	process	process	NN
cord-001835-0s7ok4uw	4091	19	.	.	.
cord-001835-0s7ok4uw	4092	1	Next	next	RB
cord-001835-0s7ok4uw	4092	2	,	,	,
cord-001835-0s7ok4uw	4092	3	a	a	DT
cord-001835-0s7ok4uw	4092	4	role	role	NN
cord-001835-0s7ok4uw	4092	5	of	of	IN
cord-001835-0s7ok4uw	4092	6	the	the	DT
cord-001835-0s7ok4uw	4092	7	C	C	NNP
cord-001835-0s7ok4uw	4092	8	-	-	HYPH
cord-001835-0s7ok4uw	4092	9	terminal	terminal	NN
cord-001835-0s7ok4uw	4092	10	effector	effector	NN
cord-001835-0s7ok4uw	4092	11	domain	domain	NN
cord-001835-0s7ok4uw	4092	12	of	of	IN
cord-001835-0s7ok4uw	4092	13	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4092	14	in	in	IN
cord-001835-0s7ok4uw	4092	15	the	the	DT
cord-001835-0s7ok4uw	4092	16	light	light	NN
cord-001835-0s7ok4uw	4092	17	-	-	HYPH
cord-001835-0s7ok4uw	4092	18	induced	induce	VBN
cord-001835-0s7ok4uw	4092	19	interaction	interaction	NN
cord-001835-0s7ok4uw	4092	20	was	be	VBD
cord-001835-0s7ok4uw	4092	21	studied	study	VBN
cord-001835-0s7ok4uw	4092	22	.	.	.
cord-001835-0s7ok4uw	4093	1	For	for	IN
cord-001835-0s7ok4uw	4093	2	this	this	DT
cord-001835-0s7ok4uw	4093	3	,	,	,
cord-001835-0s7ok4uw	4093	4	kinetics	kinetics	NN
cord-001835-0s7ok4uw	4093	5	of	of	IN
cord-001835-0s7ok4uw	4093	6	the	the	DT
cord-001835-0s7ok4uw	4093	7	Pfr	Pfr	NNP
cord-001835-0s7ok4uw	4093	8	-	-	HYPH
cord-001835-0s7ok4uw	4093	9	to	to	IN
cord-001835-0s7ok4uw	4093	10	-	-	HYPH
cord-001835-0s7ok4uw	4093	11	Pr	pr	NN
cord-001835-0s7ok4uw	4093	12	transition	transition	NN
cord-001835-0s7ok4uw	4093	13	was	be	VBD
cord-001835-0s7ok4uw	4093	14	analysed	analyse	VBN
cord-001835-0s7ok4uw	4093	15	by	by	IN
cord-001835-0s7ok4uw	4093	16	measuring	measure	VBG
cord-001835-0s7ok4uw	4093	17	of	of	IN
cord-001835-0s7ok4uw	4093	18	absorbance	absorbance	NN
cord-001835-0s7ok4uw	4093	19	at	at	IN
cord-001835-0s7ok4uw	4093	20	680	680	CD
cord-001835-0s7ok4uw	4093	21	nm	nm	NN
cord-001835-0s7ok4uw	4093	22	and	and	CC
cord-001835-0s7ok4uw	4093	23	740	740	CD
cord-001835-0s7ok4uw	4093	24	nm	nm	NN
cord-001835-0s7ok4uw	4093	25	for	for	IN
cord-001835-0s7ok4uw	4093	26	full	full	JJ
cord-001835-0s7ok4uw	4093	27	-	-	HYPH
cord-001835-0s7ok4uw	4093	28	length	length	NN
cord-001835-0s7ok4uw	4093	29	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4093	30	and	and	CC
cord-001835-0s7ok4uw	4093	31	a	a	DT
cord-001835-0s7ok4uw	4093	32	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4093	33	mutant	mutant	JJ
cord-001835-0s7ok4uw	4093	34	with	with	IN
cord-001835-0s7ok4uw	4093	35	the	the	DT
cord-001835-0s7ok4uw	4093	36	deleted	delete	VBN
cord-001835-0s7ok4uw	4093	37	C	c	NN
cord-001835-0s7ok4uw	4093	38	-	-	HYPH
cord-001835-0s7ok4uw	4093	39	terminal	terminal	NN
cord-001835-0s7ok4uw	4093	40	domain	domain	NN
cord-001835-0s7ok4uw	4093	41	.	.	.
cord-001835-0s7ok4uw	4094	1	While	while	IN
cord-001835-0s7ok4uw	4094	2	full	full	JJ
cord-001835-0s7ok4uw	4094	3	-	-	HYPH
cord-001835-0s7ok4uw	4094	4	length	length	NN
cord-001835-0s7ok4uw	4094	5	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4094	6	showed	show	VBD
cord-001835-0s7ok4uw	4094	7	the	the	DT
cord-001835-0s7ok4uw	4094	8	normal	normal	JJ
cord-001835-0s7ok4uw	4094	9	Pfr	Pfr	NNP
cord-001835-0s7ok4uw	4094	10	-	-	HYPH
cord-001835-0s7ok4uw	4094	11	to	to	IN
cord-001835-0s7ok4uw	4094	12	-	-	HYPH
cord-001835-0s7ok4uw	4094	13	Pr	pr	NN
cord-001835-0s7ok4uw	4094	14	transition	transition	NN
cord-001835-0s7ok4uw	4094	15	,	,	,
cord-001835-0s7ok4uw	4094	16	absorbance	absorbance	NN
cord-001835-0s7ok4uw	4094	17	of	of	IN
cord-001835-0s7ok4uw	4094	18	the	the	DT
cord-001835-0s7ok4uw	4094	19	mutated	mutated	JJ
cord-001835-0s7ok4uw	4094	20	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4094	21	at	at	IN
cord-001835-0s7ok4uw	4094	22	680	680	CD
cord-001835-0s7ok4uw	4094	23	nm	nm	NN
cord-001835-0s7ok4uw	4094	24	did	do	VBD
cord-001835-0s7ok4uw	4094	25	not	not	RB
cord-001835-0s7ok4uw	4094	26	raise	raise	VB
cord-001835-0s7ok4uw	4094	27	.	.	.
cord-001835-0s7ok4uw	4095	1	However	however	RB
cord-001835-0s7ok4uw	4095	2	,	,	,
cord-001835-0s7ok4uw	4095	3	740	740	CD
cord-001835-0s7ok4uw	4095	4	nm	nm	NN
cord-001835-0s7ok4uw	4095	5	absorbance	absorbance	NN
cord-001835-0s7ok4uw	4095	6	changes	change	NNS
cord-001835-0s7ok4uw	4095	7	were	be	VBD
cord-001835-0s7ok4uw	4095	8	similar	similar	JJ
cord-001835-0s7ok4uw	4095	9	for	for	IN
cord-001835-0s7ok4uw	4095	10	both	both	DT
cord-001835-0s7ok4uw	4095	11	proteins	protein	NNS
cord-001835-0s7ok4uw	4095	12	;	;	:
cord-001835-0s7ok4uw	4095	13	and	and	CC
cord-001835-0s7ok4uw	4095	14	surprisingly	surprisingly	RB
cord-001835-0s7ok4uw	4095	15	,	,	,
cord-001835-0s7ok4uw	4095	16	the	the	DT
cord-001835-0s7ok4uw	4095	17	similar	similar	JJ
cord-001835-0s7ok4uw	4095	18	dark	dark	JJ
cord-001835-0s7ok4uw	4095	19	relaxation	relaxation	NN
cord-001835-0s7ok4uw	4095	20	kinetics	kinetics	NN
cord-001835-0s7ok4uw	4095	21	was	be	VBD
cord-001835-0s7ok4uw	4095	22	observed	observe	VBN
cord-001835-0s7ok4uw	4095	23	.	.	.
cord-001835-0s7ok4uw	4096	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4096	2	propose	propose	VBP
cord-001835-0s7ok4uw	4096	3	that	that	IN
cord-001835-0s7ok4uw	4096	4	the	the	DT
cord-001835-0s7ok4uw	4096	5	impaired	impair	VBN
cord-001835-0s7ok4uw	4096	6	Pfr	Pfr	NNP
cord-001835-0s7ok4uw	4096	7	-	-	HYPH
cord-001835-0s7ok4uw	4096	8	to	to	IN
cord-001835-0s7ok4uw	4096	9	-	-	HYPH
cord-001835-0s7ok4uw	4096	10	Pr	pr	NN
cord-001835-0s7ok4uw	4096	11	transition	transition	NN
cord-001835-0s7ok4uw	4096	12	is	be	VBZ
cord-001835-0s7ok4uw	4096	13	caused	cause	VBN
cord-001835-0s7ok4uw	4096	14	by	by	IN
cord-001835-0s7ok4uw	4096	15	restricted	restrict	VBN
cord-001835-0s7ok4uw	4096	16	Pr	pr	NN
cord-001835-0s7ok4uw	4096	17	conformation	conformation	NN
cord-001835-0s7ok4uw	4096	18	in	in	IN
cord-001835-0s7ok4uw	4096	19	the	the	DT
cord-001835-0s7ok4uw	4096	20	mutant	mutant	NN
cord-001835-0s7ok4uw	4096	21	rather	rather	RB
cord-001835-0s7ok4uw	4096	22	than	than	IN
cord-001835-0s7ok4uw	4096	23	by	by	IN
cord-001835-0s7ok4uw	4096	24	fast	fast	JJ
cord-001835-0s7ok4uw	4096	25	Pr	pr	NN
cord-001835-0s7ok4uw	4096	26	-	-	HYPH
cord-001835-0s7ok4uw	4096	27	to	to	IN
cord-001835-0s7ok4uw	4096	28	-	-	HYPH
cord-001835-0s7ok4uw	4096	29	Pfr	Pfr	NNP
cord-001835-0s7ok4uw	4096	30	relaxation	relaxation	NN
cord-001835-0s7ok4uw	4096	31	.	.	.
cord-001835-0s7ok4uw	4097	1	Understanding	understand	VBG
cord-001835-0s7ok4uw	4097	2	the	the	DT
cord-001835-0s7ok4uw	4097	3	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4097	4	of	of	IN
cord-001835-0s7ok4uw	4097	5	the	the	DT
cord-001835-0s7ok4uw	4097	6	BphP1	BphP1	NNP
cord-001835-0s7ok4uw	4097	7	light	light	NN
cord-001835-0s7ok4uw	4097	8	-	-	HYPH
cord-001835-0s7ok4uw	4097	9	induced	induce	VBN
cord-001835-0s7ok4uw	4097	10	structural	structural	JJ
cord-001835-0s7ok4uw	4097	11	changes	change	NNS
cord-001835-0s7ok4uw	4097	12	and	and	CC
cord-001835-0s7ok4uw	4097	13	the	the	DT
cord-001835-0s7ok4uw	4097	14	protomer	protomer	NN
cord-001835-0s7ok4uw	4097	15	interaction	interaction	NN
cord-001835-0s7ok4uw	4097	16	should	should	MD
cord-001835-0s7ok4uw	4097	17	advance	advance	VB
cord-001835-0s7ok4uw	4097	18	engineering	engineering	NN
cord-001835-0s7ok4uw	4097	19	of	of	IN
cord-001835-0s7ok4uw	4097	20	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	4097	21	phytochromes	phytochrome	NNS
cord-001835-0s7ok4uw	4097	22	into	into	IN
cord-001835-0s7ok4uw	4097	23	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	4097	24	probes	probe	NNS
cord-001835-0s7ok4uw	4097	25	and	and	CC
cord-001835-0s7ok4uw	4097	26	optogenetic	optogenetic	JJ
cord-001835-0s7ok4uw	4097	27	tools	tool	NNS
cord-001835-0s7ok4uw	4097	28	.	.	.
cord-001835-0s7ok4uw	4097	29	 	 	_SP
cord-001835-0s7ok4uw	4098	1	Antibody	antibody	NN
cord-001835-0s7ok4uw	4098	2	detection	detection	NN
cord-001835-0s7ok4uw	4098	3	is	be	VBZ
cord-001835-0s7ok4uw	4098	4	an	an	DT
cord-001835-0s7ok4uw	4098	5	integral	integral	JJ
cord-001835-0s7ok4uw	4098	6	part	part	NN
cord-001835-0s7ok4uw	4098	7	of	of	IN
cord-001835-0s7ok4uw	4098	8	many	many	JJ
cord-001835-0s7ok4uw	4098	9	diagnostic	diagnostic	JJ
cord-001835-0s7ok4uw	4098	10	strategies	strategy	NNS
cord-001835-0s7ok4uw	4098	11	,	,	,
cord-001835-0s7ok4uw	4098	12	most	most	RBS
cord-001835-0s7ok4uw	4098	13	crucially	crucially	RB
cord-001835-0s7ok4uw	4098	14	so	so	RB
cord-001835-0s7ok4uw	4098	15	when	when	WRB
cord-001835-0s7ok4uw	4098	16	infectious	infectious	JJ
cord-001835-0s7ok4uw	4098	17	diseases	disease	NNS
cord-001835-0s7ok4uw	4098	18	are	be	VBP
cord-001835-0s7ok4uw	4098	19	involved	involve	VBN
cord-001835-0s7ok4uw	4098	20	.	.	.
cord-001835-0s7ok4uw	4099	1	Currently	currently	RB
cord-001835-0s7ok4uw	4099	2	used	use	VBN
cord-001835-0s7ok4uw	4099	3	assays	assay	NNS
cord-001835-0s7ok4uw	4099	4	,	,	,
cord-001835-0s7ok4uw	4099	5	such	such	JJ
cord-001835-0s7ok4uw	4099	6	as	as	IN
cord-001835-0s7ok4uw	4099	7	ELISA	ELISA	NNP
cord-001835-0s7ok4uw	4099	8	or	or	CC
cord-001835-0s7ok4uw	4099	9	SPR	SPR	NNP
cord-001835-0s7ok4uw	4099	10	,	,	,
cord-001835-0s7ok4uw	4099	11	enable	enable	VB
cord-001835-0s7ok4uw	4099	12	detection	detection	NN
cord-001835-0s7ok4uw	4099	13	of	of	IN
cord-001835-0s7ok4uw	4099	14	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4099	15	in	in	IN
cord-001835-0s7ok4uw	4099	16	the	the	DT
cord-001835-0s7ok4uw	4099	17	laboratory	laboratory	NN
cord-001835-0s7ok4uw	4099	18	with	with	IN
cord-001835-0s7ok4uw	4099	19	high	high	JJ
cord-001835-0s7ok4uw	4099	20	sensitivity	sensitivity	NN
cord-001835-0s7ok4uw	4099	21	,	,	,
cord-001835-0s7ok4uw	4099	22	yet	yet	CC
cord-001835-0s7ok4uw	4099	23	a	a	DT
cord-001835-0s7ok4uw	4099	24	translation	translation	NN
cord-001835-0s7ok4uw	4099	25	of	of	IN
cord-001835-0s7ok4uw	4099	26	these	these	DT
cord-001835-0s7ok4uw	4099	27	technologies	technology	NNS
cord-001835-0s7ok4uw	4099	28	to	to	IN
cord-001835-0s7ok4uw	4099	29	an	an	DT
cord-001835-0s7ok4uw	4099	30	application	application	NN
cord-001835-0s7ok4uw	4099	31	outside	outside	IN
cord-001835-0s7ok4uw	4099	32	of	of	IN
cord-001835-0s7ok4uw	4099	33	the	the	DT
cord-001835-0s7ok4uw	4099	34	laboratory	laboratory	NN
cord-001835-0s7ok4uw	4099	35	setting	setting	NN
cord-001835-0s7ok4uw	4099	36	is	be	VBZ
cord-001835-0s7ok4uw	4099	37	far	far	RB
cord-001835-0s7ok4uw	4099	38	from	from	IN
cord-001835-0s7ok4uw	4099	39	trivial	trivial	JJ
cord-001835-0s7ok4uw	4099	40	.	.	.
cord-001835-0s7ok4uw	4100	1	Problematically	problematically	RB
cord-001835-0s7ok4uw	4100	2	,	,	,
cord-001835-0s7ok4uw	4100	3	the	the	DT
cord-001835-0s7ok4uw	4100	4	burden	burden	NN
cord-001835-0s7ok4uw	4100	5	of	of	IN
cord-001835-0s7ok4uw	4100	6	disease	disease	NN
cord-001835-0s7ok4uw	4100	7	for	for	IN
cord-001835-0s7ok4uw	4100	8	many	many	JJ
cord-001835-0s7ok4uw	4100	9	infectious	infectious	JJ
cord-001835-0s7ok4uw	4100	10	diseases	disease	NNS
cord-001835-0s7ok4uw	4100	11	is	be	VBZ
cord-001835-0s7ok4uw	4100	12	carried	carry	VBN
cord-001835-0s7ok4uw	4100	13	precisely	precisely	RB
cord-001835-0s7ok4uw	4100	14	by	by	IN
cord-001835-0s7ok4uw	4100	15	those	those	DT
cord-001835-0s7ok4uw	4100	16	countries	country	NNS
cord-001835-0s7ok4uw	4100	17	where	where	WRB
cord-001835-0s7ok4uw	4100	18	access	access	NN
cord-001835-0s7ok4uw	4100	19	to	to	IN
cord-001835-0s7ok4uw	4100	20	laboratory	laboratory	NN
cord-001835-0s7ok4uw	4100	21	facilities	facility	NNS
cord-001835-0s7ok4uw	4100	22	is	be	VBZ
cord-001835-0s7ok4uw	4100	23	severely	severely	RB
cord-001835-0s7ok4uw	4100	24	limited	limited	JJ
cord-001835-0s7ok4uw	4100	25	.	.	.
cord-001835-0s7ok4uw	4101	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4101	2	therefore	therefore	RB
cord-001835-0s7ok4uw	4101	3	developed	develop	VBD
cord-001835-0s7ok4uw	4101	4	a	a	DT
cord-001835-0s7ok4uw	4101	5	novel	novel	NN
cord-001835-0s7ok4uw	4101	6	,	,	,
cord-001835-0s7ok4uw	4101	7	one	one	CD
cord-001835-0s7ok4uw	4101	8	-	-	HYPH
cord-001835-0s7ok4uw	4101	9	step	step	NN
cord-001835-0s7ok4uw	4101	10	assay	assay	NN
cord-001835-0s7ok4uw	4101	11	that	that	WDT
cord-001835-0s7ok4uw	4101	12	allows	allow	VBZ
cord-001835-0s7ok4uw	4101	13	the	the	DT
cord-001835-0s7ok4uw	4101	14	detection	detection	NN
cord-001835-0s7ok4uw	4101	15	of	of	IN
cord-001835-0s7ok4uw	4101	16	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4101	17	directly	directly	RB
cord-001835-0s7ok4uw	4101	18	in	in	IN
cord-001835-0s7ok4uw	4101	19	solution	solution	NN
cord-001835-0s7ok4uw	4101	20	using	use	VBG
cord-001835-0s7ok4uw	4101	21	a	a	DT
cord-001835-0s7ok4uw	4101	22	luminescent	luminescent	JJ
cord-001835-0s7ok4uw	4101	23	sensor	sensor	NN
cord-001835-0s7ok4uw	4101	24	protein	protein	NN
cord-001835-0s7ok4uw	4101	25	.	.	.
cord-001835-0s7ok4uw	4102	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4102	2	strategy	strategy	NN
cord-001835-0s7ok4uw	4102	3	is	be	VBZ
cord-001835-0s7ok4uw	4102	4	based	base	VBN
cord-001835-0s7ok4uw	4102	5	on	on	IN
cord-001835-0s7ok4uw	4102	6	the	the	DT
cord-001835-0s7ok4uw	4102	7	use	use	NN
cord-001835-0s7ok4uw	4102	8	of	of	IN
cord-001835-0s7ok4uw	4102	9	a	a	DT
cord-001835-0s7ok4uw	4102	10	bright	bright	JJ
cord-001835-0s7ok4uw	4102	11	luciferase	luciferase	NN
cord-001835-0s7ok4uw	4102	12	,	,	,
cord-001835-0s7ok4uw	4102	13	NanoLuc	NanoLuc	NNP
cord-001835-0s7ok4uw	4102	14	,	,	,
cord-001835-0s7ok4uw	4102	15	tethered	tether	VBN
cord-001835-0s7ok4uw	4102	16	to	to	IN
cord-001835-0s7ok4uw	4102	17	a	a	DT
cord-001835-0s7ok4uw	4102	18	green	green	JJ
cord-001835-0s7ok4uw	4102	19	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	4102	20	protein	protein	NN
cord-001835-0s7ok4uw	4102	21	(	(	-LRB-
cord-001835-0s7ok4uw	4102	22	mNeonGreen	mNeonGreen	NNP
cord-001835-0s7ok4uw	4102	23	)	)	-RRB-
cord-001835-0s7ok4uw	4102	24	via	via	IN
cord-001835-0s7ok4uw	4102	25	a	a	DT
cord-001835-0s7ok4uw	4102	26	semi	semi	JJ
cord-001835-0s7ok4uw	4102	27	-	-	JJ
cord-001835-0s7ok4uw	4102	28	flexible	flexible	JJ
cord-001835-0s7ok4uw	4102	29	linker	linker	NN
cord-001835-0s7ok4uw	4102	30	containing	contain	VBG
cord-001835-0s7ok4uw	4102	31	two	two	CD
cord-001835-0s7ok4uw	4102	32	epitope	epitope	NN
cord-001835-0s7ok4uw	4102	33	sequences	sequence	NNS
cord-001835-0s7ok4uw	4102	34	.	.	.
cord-001835-0s7ok4uw	4103	1	Crucially	crucially	RB
cord-001835-0s7ok4uw	4103	2	,	,	,
cord-001835-0s7ok4uw	4103	3	two	two	CD
cord-001835-0s7ok4uw	4103	4	small	small	JJ
cord-001835-0s7ok4uw	4103	5	helper	helper	NN
cord-001835-0s7ok4uw	4103	6	domains	domain	NNS
cord-001835-0s7ok4uw	4103	7	were	be	VBD
cord-001835-0s7ok4uw	4103	8	fused	fuse	VBN
cord-001835-0s7ok4uw	4103	9	to	to	IN
cord-001835-0s7ok4uw	4103	10	the	the	DT
cord-001835-0s7ok4uw	4103	11	protein	protein	NN
cord-001835-0s7ok4uw	4103	12	termini	termini	NNP
cord-001835-0s7ok4uw	4103	13	.	.	.
cord-001835-0s7ok4uw	4104	1	These	these	DT
cord-001835-0s7ok4uw	4104	2	domains	domain	NNS
cord-001835-0s7ok4uw	4104	3	keep	keep	VBP
cord-001835-0s7ok4uw	4104	4	Nano	Nano	NNP
cord-001835-0s7ok4uw	4104	5	-	-	HYPH
cord-001835-0s7ok4uw	4104	6	Luc	Luc	NNP
cord-001835-0s7ok4uw	4104	7	and	and	CC
cord-001835-0s7ok4uw	4104	8	mNeonGreen	mNeonGreen	VBN
cord-001835-0s7ok4uw	4104	9	in	in	IN
cord-001835-0s7ok4uw	4104	10	close	close	JJ
cord-001835-0s7ok4uw	4104	11	proximity	proximity	NN
cord-001835-0s7ok4uw	4104	12	in	in	IN
cord-001835-0s7ok4uw	4104	13	the	the	DT
cord-001835-0s7ok4uw	4104	14	absence	absence	NN
cord-001835-0s7ok4uw	4104	15	of	of	IN
cord-001835-0s7ok4uw	4104	16	antibody	antibody	NN
cord-001835-0s7ok4uw	4104	17	,	,	,
cord-001835-0s7ok4uw	4104	18	enabling	enable	VBG
cord-001835-0s7ok4uw	4104	19	efficient	efficient	JJ
cord-001835-0s7ok4uw	4104	20	Bioluminescence	Bioluminescence	NNP
cord-001835-0s7ok4uw	4104	21	Resonance	Resonance	NNP
cord-001835-0s7ok4uw	4104	22	Energy	Energy	NNP
cord-001835-0s7ok4uw	4104	23	Transfer	Transfer	NNP
cord-001835-0s7ok4uw	4104	24	(	(	-LRB-
cord-001835-0s7ok4uw	4104	25	BRET	BRET	NNP
cord-001835-0s7ok4uw	4104	26	)	)	-RRB-
cord-001835-0s7ok4uw	4104	27	.	.	.
cord-001835-0s7ok4uw	4105	1	Binding	bind	VBG
cord-001835-0s7ok4uw	4105	2	of	of	IN
cord-001835-0s7ok4uw	4105	3	antibody	antibody	NN
cord-001835-0s7ok4uw	4105	4	to	to	IN
cord-001835-0s7ok4uw	4105	5	the	the	DT
cord-001835-0s7ok4uw	4105	6	epitopes	epitope	NNS
cord-001835-0s7ok4uw	4105	7	in	in	IN
cord-001835-0s7ok4uw	4105	8	the	the	DT
cord-001835-0s7ok4uw	4105	9	sensor	sensor	NN
cord-001835-0s7ok4uw	4105	10	proteins	protein	NNS
cord-001835-0s7ok4uw	4105	11	linker	linker	NN
cord-001835-0s7ok4uw	4105	12	domain	domain	NN
cord-001835-0s7ok4uw	4105	13	pulls	pull	VBZ
cord-001835-0s7ok4uw	4105	14	the	the	DT
cord-001835-0s7ok4uw	4105	15	BRET	BRET	NNP
cord-001835-0s7ok4uw	4105	16	partners	partner	NNS
cord-001835-0s7ok4uw	4105	17	apart	apart	RB
cord-001835-0s7ok4uw	4105	18	,	,	,
cord-001835-0s7ok4uw	4105	19	effectively	effectively	RB
cord-001835-0s7ok4uw	4105	20	changing	change	VBG
cord-001835-0s7ok4uw	4105	21	the	the	DT
cord-001835-0s7ok4uw	4105	22	color	color	NN
cord-001835-0s7ok4uw	4105	23	of	of	IN
cord-001835-0s7ok4uw	4105	24	emission	emission	NN
cord-001835-0s7ok4uw	4105	25	from	from	IN
cord-001835-0s7ok4uw	4105	26	green	green	JJ
cord-001835-0s7ok4uw	4105	27	to	to	IN
cord-001835-0s7ok4uw	4105	28	blue	blue	JJ
cord-001835-0s7ok4uw	4105	29	.	.	.
cord-001835-0s7ok4uw	4106	1	The	the	DT
cord-001835-0s7ok4uw	4106	2	assay	assay	NN
cord-001835-0s7ok4uw	4106	3	allowed	allow	VBD
cord-001835-0s7ok4uw	4106	4	the	the	DT
cord-001835-0s7ok4uw	4106	5	detection	detection	NN
cord-001835-0s7ok4uw	4106	6	of	of	IN
cord-001835-0s7ok4uw	4106	7	picomolar	picomolar	JJ
cord-001835-0s7ok4uw	4106	8	amounts	amount	NNS
cord-001835-0s7ok4uw	4106	9	of	of	IN
cord-001835-0s7ok4uw	4106	10	anti	anti	JJ
cord-001835-0s7ok4uw	4106	11	HIV1-p17	HIV1-p17	NNP
cord-001835-0s7ok4uw	4106	12	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4106	13	directly	directly	RB
cord-001835-0s7ok4uw	4106	14	in	in	IN
cord-001835-0s7ok4uw	4106	15	solution	solution	NN
cord-001835-0s7ok4uw	4106	16	,	,	,
cord-001835-0s7ok4uw	4106	17	both	both	DT
cord-001835-0s7ok4uw	4106	18	under	under	IN
cord-001835-0s7ok4uw	4106	19	optimized	optimize	VBN
cord-001835-0s7ok4uw	4106	20	buffer	buffer	NN
cord-001835-0s7ok4uw	4106	21	conditions	condition	NNS
cord-001835-0s7ok4uw	4106	22	and	and	CC
cord-001835-0s7ok4uw	4106	23	in	in	IN
cord-001835-0s7ok4uw	4106	24	blood	blood	NN
cord-001835-0s7ok4uw	4106	25	plasma	plasma	NN
cord-001835-0s7ok4uw	4106	26	.	.	.
cord-001835-0s7ok4uw	4107	1	In	in	IN
cord-001835-0s7ok4uw	4107	2	principle	principle	NN
cord-001835-0s7ok4uw	4107	3	.	.	.
cord-001835-0s7ok4uw	4108	1	the	the	DT
cord-001835-0s7ok4uw	4108	2	modular	modular	JJ
cord-001835-0s7ok4uw	4108	3	sensor	sensor	NN
cord-001835-0s7ok4uw	4108	4	architecture	architecture	NN
cord-001835-0s7ok4uw	4108	5	should	should	MD
cord-001835-0s7ok4uw	4108	6	allow	allow	VB
cord-001835-0s7ok4uw	4108	7	detection	detection	NN
cord-001835-0s7ok4uw	4108	8	of	of	IN
cord-001835-0s7ok4uw	4108	9	any	any	DT
cord-001835-0s7ok4uw	4108	10	antibody	antibody	NN
cord-001835-0s7ok4uw	4108	11	with	with	IN
cord-001835-0s7ok4uw	4108	12	a	a	DT
cord-001835-0s7ok4uw	4108	13	well	well	RB
cord-001835-0s7ok4uw	4108	14	-	-	HYPH
cord-001835-0s7ok4uw	4108	15	defined	define	VBN
cord-001835-0s7ok4uw	4108	16	epitope	epitope	NN
cord-001835-0s7ok4uw	4108	17	of	of	IN
cord-001835-0s7ok4uw	4108	18	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	4108	19	affinity	affinity	NN
cord-001835-0s7ok4uw	4108	20	.	.	.
cord-001835-0s7ok4uw	4109	1	To	to	TO
cord-001835-0s7ok4uw	4109	2	demonstrate	demonstrate	VB
cord-001835-0s7ok4uw	4109	3	this	this	DT
cord-001835-0s7ok4uw	4109	4	,	,	,
cord-001835-0s7ok4uw	4109	5	the	the	DT
cord-001835-0s7ok4uw	4109	6	HIV	HIV	NNP
cord-001835-0s7ok4uw	4109	7	-	-	HYPH
cord-001835-0s7ok4uw	4109	8	epitopes	epitope	NNS
cord-001835-0s7ok4uw	4109	9	were	be	VBD
cord-001835-0s7ok4uw	4109	10	substituted	substitute	VBN
cord-001835-0s7ok4uw	4109	11	for	for	IN
cord-001835-0s7ok4uw	4109	12	two	two	CD
cord-001835-0s7ok4uw	4109	13	HA	HA	NNP
cord-001835-0s7ok4uw	4109	14	-	-	HYPH
cord-001835-0s7ok4uw	4109	15	tag	tag	NN
cord-001835-0s7ok4uw	4109	16	epitopes	epitope	NNS
cord-001835-0s7ok4uw	4109	17	,	,	,
cord-001835-0s7ok4uw	4109	18	yielding	yield	VBG
cord-001835-0s7ok4uw	4109	19	a	a	DT
cord-001835-0s7ok4uw	4109	20	sensor	sensor	NN
cord-001835-0s7ok4uw	4109	21	that	that	WDT
cord-001835-0s7ok4uw	4109	22	enabled	enable	VBD
cord-001835-0s7ok4uw	4109	23	the	the	DT
cord-001835-0s7ok4uw	4109	24	detection	detection	NN
cord-001835-0s7ok4uw	4109	25	of	of	IN
cord-001835-0s7ok4uw	4109	26	picomolar	picomolar	JJ
cord-001835-0s7ok4uw	4109	27	amounts	amount	NNS
cord-001835-0s7ok4uw	4109	28	of	of	IN
cord-001835-0s7ok4uw	4109	29	anti	anti	JJ
cord-001835-0s7ok4uw	4109	30	-	-	JJ
cord-001835-0s7ok4uw	4109	31	HA	HA	NNP
cord-001835-0s7ok4uw	4109	32	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4109	33	.	.	.
cord-001835-0s7ok4uw	4110	1	The	the	DT
cord-001835-0s7ok4uw	4110	2	simple	simple	JJ
cord-001835-0s7ok4uw	4110	3	optical	optical	JJ
cord-001835-0s7ok4uw	4110	4	readout	readout	NN
cord-001835-0s7ok4uw	4110	5	provided	provide	VBN
cord-001835-0s7ok4uw	4110	6	by	by	IN
cord-001835-0s7ok4uw	4110	7	the	the	DT
cord-001835-0s7ok4uw	4110	8	sensor	sensor	NN
cord-001835-0s7ok4uw	4110	9	system	system	NN
cord-001835-0s7ok4uw	4110	10	allowed	allow	VBD
cord-001835-0s7ok4uw	4110	11	us	-PRON-	PRP
cord-001835-0s7ok4uw	4110	12	to	to	TO
cord-001835-0s7ok4uw	4110	13	record	record	VB
cord-001835-0s7ok4uw	4110	14	the	the	DT
cord-001835-0s7ok4uw	4110	15	emitted	emit	VBN
cord-001835-0s7ok4uw	4110	16	signal	signal	NN
cord-001835-0s7ok4uw	4110	17	with	with	IN
cord-001835-0s7ok4uw	4110	18	a	a	DT
cord-001835-0s7ok4uw	4110	19	conventional	conventional	JJ
cord-001835-0s7ok4uw	4110	20	mobile	mobile	JJ
cord-001835-0s7ok4uw	4110	21	phone	phone	NN
cord-001835-0s7ok4uw	4110	22	camera	camera	NN
cord-001835-0s7ok4uw	4110	23	.	.	.
cord-001835-0s7ok4uw	4111	1	A	a	DT
cord-001835-0s7ok4uw	4111	2	simple	simple	JJ
cord-001835-0s7ok4uw	4111	3	software	software	NN
cord-001835-0s7ok4uw	4111	4	application	application	NN
cord-001835-0s7ok4uw	4111	5	that	that	WDT
cord-001835-0s7ok4uw	4111	6	analyzes	analyze	VBZ
cord-001835-0s7ok4uw	4111	7	the	the	DT
cord-001835-0s7ok4uw	4111	8	image	image	NN
cord-001835-0s7ok4uw	4111	9	based	base	VBN
cord-001835-0s7ok4uw	4111	10	on	on	IN
cord-001835-0s7ok4uw	4111	11	RGB	rgb	NN
cord-001835-0s7ok4uw	4111	12	values	value	NNS
cord-001835-0s7ok4uw	4111	13	sufficed	suffice	VBD
cord-001835-0s7ok4uw	4111	14	to	to	TO
cord-001835-0s7ok4uw	4111	15	interpret	interpret	VB
cord-001835-0s7ok4uw	4111	16	the	the	DT
cord-001835-0s7ok4uw	4111	17	recorded	record	VBN
cord-001835-0s7ok4uw	4111	18	image	image	NN
cord-001835-0s7ok4uw	4111	19	vis	vis	FW
cord-001835-0s7ok4uw	4111	20	-	-	HYPH
cord-001835-0s7ok4uw	4111	21	a	a	FW
cord-001835-0s7ok4uw	4111	22	-	-	HYPH
cord-001835-0s7ok4uw	4111	23	vis	vis	FW
cord-001835-0s7ok4uw	4111	24	the	the	DT
cord-001835-0s7ok4uw	4111	25	presence	presence	NN
cord-001835-0s7ok4uw	4111	26	of	of	IN
cord-001835-0s7ok4uw	4111	27	antibody	antibody	NN
cord-001835-0s7ok4uw	4111	28	.	.	.
cord-001835-0s7ok4uw	4112	1	Bearing	bear	VBG
cord-001835-0s7ok4uw	4112	2	in	in	IN
cord-001835-0s7ok4uw	4112	3	mind	mind	NN
cord-001835-0s7ok4uw	4112	4	the	the	DT
cord-001835-0s7ok4uw	4112	5	eventually	eventually	RB
cord-001835-0s7ok4uw	4112	6	envisioned	envision	VBD
cord-001835-0s7ok4uw	4112	7	application	application	NN
cord-001835-0s7ok4uw	4112	8	in	in	IN
cord-001835-0s7ok4uw	4112	9	a	a	DT
cord-001835-0s7ok4uw	4112	10	point	point	NN
cord-001835-0s7ok4uw	4112	11	-	-	HYPH
cord-001835-0s7ok4uw	4112	12	of	of	IN
cord-001835-0s7ok4uw	4112	13	-	-	HYPH
cord-001835-0s7ok4uw	4112	14	care	care	NN
cord-001835-0s7ok4uw	4112	15	diagnostic	diagnostic	JJ
cord-001835-0s7ok4uw	4112	16	setting	setting	NN
cord-001835-0s7ok4uw	4112	17	,	,	,
cord-001835-0s7ok4uw	4112	18	this	this	DT
cord-001835-0s7ok4uw	4112	19	combination	combination	NN
cord-001835-0s7ok4uw	4112	20	of	of	IN
cord-001835-0s7ok4uw	4112	21	sensor	sensor	NN
cord-001835-0s7ok4uw	4112	22	recording	recording	NN
cord-001835-0s7ok4uw	4112	23	and	and	CC
cord-001835-0s7ok4uw	4112	24	interpretation	interpretation	NN
cord-001835-0s7ok4uw	4112	25	using	use	VBG
cord-001835-0s7ok4uw	4112	26	nothing	nothing	NN
cord-001835-0s7ok4uw	4112	27	more	more	JJR
cord-001835-0s7ok4uw	4112	28	than	than	IN
cord-001835-0s7ok4uw	4112	29	a	a	DT
cord-001835-0s7ok4uw	4112	30	mobile	mobile	JJ
cord-001835-0s7ok4uw	4112	31	phone	phone	NN
cord-001835-0s7ok4uw	4112	32	and	and	CC
cord-001835-0s7ok4uw	4112	33	a	a	DT
cord-001835-0s7ok4uw	4112	34	software	software	NN
cord-001835-0s7ok4uw	4112	35	application	application	NN
cord-001835-0s7ok4uw	4112	36	holds	hold	VBZ
cord-001835-0s7ok4uw	4112	37	considerable	considerable	JJ
cord-001835-0s7ok4uw	4112	38	diagnostic	diagnostic	JJ
cord-001835-0s7ok4uw	4112	39	potential	potential	NN
cord-001835-0s7ok4uw	4112	40	.	.	.
cord-001835-0s7ok4uw	4113	1	Beyond	beyond	IN
cord-001835-0s7ok4uw	4113	2	point	point	NN
cord-001835-0s7ok4uw	4113	3	-	-	HYPH
cord-001835-0s7ok4uw	4113	4	of	of	IN
cord-001835-0s7ok4uw	4113	5	-	-	HYPH
cord-001835-0s7ok4uw	4113	6	care	care	NN
cord-001835-0s7ok4uw	4113	7	diagnosis	diagnosis	NN
cord-001835-0s7ok4uw	4113	8	of	of	IN
cord-001835-0s7ok4uw	4113	9	infectious	infectious	JJ
cord-001835-0s7ok4uw	4113	10	diseases	disease	NNS
cord-001835-0s7ok4uw	4113	11	,	,	,
cord-001835-0s7ok4uw	4113	12	a	a	DT
cord-001835-0s7ok4uw	4113	13	simple	simple	JJ
cord-001835-0s7ok4uw	4113	14	assay	assay	NN
cord-001835-0s7ok4uw	4113	15	to	to	TO
cord-001835-0s7ok4uw	4113	16	detect	detect	VB
cord-001835-0s7ok4uw	4113	17	and	and	CC
cord-001835-0s7ok4uw	4113	18	quantify	quantify	VB
cord-001835-0s7ok4uw	4113	19	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4113	20	directly	directly	RB
cord-001835-0s7ok4uw	4113	21	in	in	IN
cord-001835-0s7ok4uw	4113	22	solution	solution	NN
cord-001835-0s7ok4uw	4113	23	could	could	MD
cord-001835-0s7ok4uw	4113	24	also	also	RB
cord-001835-0s7ok4uw	4113	25	have	have	VB
cord-001835-0s7ok4uw	4113	26	a	a	DT
cord-001835-0s7ok4uw	4113	27	substantial	substantial	JJ
cord-001835-0s7ok4uw	4113	28	impact	impact	NN
cord-001835-0s7ok4uw	4113	29	in	in	IN
cord-001835-0s7ok4uw	4113	30	other	other	JJ
cord-001835-0s7ok4uw	4113	31	fields	field	NNS
cord-001835-0s7ok4uw	4113	32	.	.	.
cord-001835-0s7ok4uw	4114	1	Antibodies	antibody	NNS
cord-001835-0s7ok4uw	4114	2	are	be	VBP
cord-001835-0s7ok4uw	4114	3	ubiquitous	ubiquitous	JJ
cord-001835-0s7ok4uw	4114	4	in	in	IN
cord-001835-0s7ok4uw	4114	5	biotechnology	biotechnology	NN
cord-001835-0s7ok4uw	4114	6	,	,	,
cord-001835-0s7ok4uw	4114	7	and	and	CC
cord-001835-0s7ok4uw	4114	8	this	this	DT
cord-001835-0s7ok4uw	4114	9	is	be	VBZ
cord-001835-0s7ok4uw	4114	10	reflected	reflect	VBN
cord-001835-0s7ok4uw	4114	11	by	by	IN
cord-001835-0s7ok4uw	4114	12	the	the	DT
cord-001835-0s7ok4uw	4114	13	plethora	plethora	NN
cord-001835-0s7ok4uw	4114	14	of	of	IN
cord-001835-0s7ok4uw	4114	15	potential	potential	JJ
cord-001835-0s7ok4uw	4114	16	sensor	sensor	NN
cord-001835-0s7ok4uw	4114	17	applications	application	NNS
cord-001835-0s7ok4uw	4114	18	,	,	,
cord-001835-0s7ok4uw	4114	19	which	which	WDT
cord-001835-0s7ok4uw	4114	20	range	range	VBP
cord-001835-0s7ok4uw	4114	21	from	from	IN
cord-001835-0s7ok4uw	4114	22	a	a	DT
cord-001835-0s7ok4uw	4114	23	role	role	NN
cord-001835-0s7ok4uw	4114	24	in	in	IN
cord-001835-0s7ok4uw	4114	25	microfluidic	microfluidic	JJ
cord-001835-0s7ok4uw	4114	26	circuits	circuit	NNS
cord-001835-0s7ok4uw	4114	27	or	or	CC
cord-001835-0s7ok4uw	4114	28	monitoring	monitor	VBG
cord-001835-0s7ok4uw	4114	29	the	the	DT
cord-001835-0s7ok4uw	4114	30	biotechnological	biotechnological	JJ
cord-001835-0s7ok4uw	4114	31	production	production	NN
cord-001835-0s7ok4uw	4114	32	of	of	IN
cord-001835-0s7ok4uw	4114	33	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4114	34	,	,	,
cord-001835-0s7ok4uw	4114	35	including	include	VBG
cord-001835-0s7ok4uw	4114	36	validation	validation	NN
cord-001835-0s7ok4uw	4114	37	of	of	IN
cord-001835-0s7ok4uw	4114	38	bispecificity	bispecificity	NN
cord-001835-0s7ok4uw	4114	39	,	,	,
cord-001835-0s7ok4uw	4114	40	to	to	IN
cord-001835-0s7ok4uw	4114	41	veterinary	veterinary	JJ
cord-001835-0s7ok4uw	4114	42	applications	application	NNS
cord-001835-0s7ok4uw	4114	43	,	,	,
cord-001835-0s7ok4uw	4114	44	diagnosis	diagnosis	NN
cord-001835-0s7ok4uw	4114	45	of	of	IN
cord-001835-0s7ok4uw	4114	46	autoimmune	autoimmune	JJ
cord-001835-0s7ok4uw	4114	47	diseases	disease	NNS
cord-001835-0s7ok4uw	4114	48	and	and	CC
cord-001835-0s7ok4uw	4114	49	monitoring	monitor	VBG
cord-001835-0s7ok4uw	4114	50	the	the	DT
cord-001835-0s7ok4uw	4114	51	success	success	NN
cord-001835-0s7ok4uw	4114	52	of	of	IN
cord-001835-0s7ok4uw	4114	53	vaccination	vaccination	NN
cord-001835-0s7ok4uw	4114	54	campaigns	campaign	NNS
cord-001835-0s7ok4uw	4114	55	.	.	.
cord-001835-0s7ok4uw	4115	1	The	the	DT
cord-001835-0s7ok4uw	4115	2	continually	continually	RB
cord-001835-0s7ok4uw	4115	3	growing	grow	VBG
cord-001835-0s7ok4uw	4115	4	Protein	Protein	NNP
cord-001835-0s7ok4uw	4115	5	Data	Data	NNP
cord-001835-0s7ok4uw	4115	6	Bank	Bank	NNP
cord-001835-0s7ok4uw	4115	7	(	(	-LRB-
cord-001835-0s7ok4uw	4115	8	PDB	PDB	NNP
cord-001835-0s7ok4uw	4115	9	)	)	-RRB-
cord-001835-0s7ok4uw	4115	10	has	have	VBZ
cord-001835-0s7ok4uw	4115	11	been	be	VBN
cord-001835-0s7ok4uw	4115	12	a	a	DT
cord-001835-0s7ok4uw	4115	13	key	key	JJ
cord-001835-0s7ok4uw	4115	14	resource	resource	NN
cord-001835-0s7ok4uw	4115	15	for	for	IN
cord-001835-0s7ok4uw	4115	16	general	general	JJ
cord-001835-0s7ok4uw	4115	17	principles	principle	NNS
cord-001835-0s7ok4uw	4115	18	of	of	IN
cord-001835-0s7ok4uw	4115	19	protein	protein	NN
cord-001835-0s7ok4uw	4115	20	structure	structure	NN
cord-001835-0s7ok4uw	4115	21	.	.	.
cord-001835-0s7ok4uw	4116	1	For	for	IN
cord-001835-0s7ok4uw	4116	2	example	example	NN
cord-001835-0s7ok4uw	4116	3	,	,	,
cord-001835-0s7ok4uw	4116	4	parsing	parse	VBG
cord-001835-0s7ok4uw	4116	5	structural	structural	JJ
cord-001835-0s7ok4uw	4116	6	observations	observation	NNS
cord-001835-0s7ok4uw	4116	7	in	in	IN
cord-001835-0s7ok4uw	4116	8	the	the	DT
cord-001835-0s7ok4uw	4116	9	PDB	PDB	NNP
cord-001835-0s7ok4uw	4116	10	into	into	IN
cord-001835-0s7ok4uw	4116	11	simple	simple	JJ
cord-001835-0s7ok4uw	4116	12	geometric	geometric	JJ
cord-001835-0s7ok4uw	4116	13	descriptors	descriptor	NNS
cord-001835-0s7ok4uw	4116	14	has	have	VBZ
cord-001835-0s7ok4uw	4116	15	given	give	VBN
cord-001835-0s7ok4uw	4116	16	rise	rise	NN
cord-001835-0s7ok4uw	4116	17	to	to	IN
cord-001835-0s7ok4uw	4116	18	statistical	statistical	JJ
cord-001835-0s7ok4uw	4116	19	energy	energy	NN
cord-001835-0s7ok4uw	4116	20	functions	function	NNS
cord-001835-0s7ok4uw	4116	21	.	.	.
cord-001835-0s7ok4uw	4117	1	Here	here	RB
cord-001835-0s7ok4uw	4117	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	4117	3	present	present	VBP
cord-001835-0s7ok4uw	4117	4	a	a	DT
cord-001835-0s7ok4uw	4117	5	novel	novel	JJ
cord-001835-0s7ok4uw	4117	6	strategy	strategy	NN
cord-001835-0s7ok4uw	4117	7	for	for	IN
cord-001835-0s7ok4uw	4117	8	mining	mine	VBG
cord-001835-0s7ok4uw	4117	9	the	the	DT
cord-001835-0s7ok4uw	4117	10	PDB	PDB	NNP
cord-001835-0s7ok4uw	4117	11	on	on	IN
cord-001835-0s7ok4uw	4117	12	the	the	DT
cord-001835-0s7ok4uw	4117	13	basis	basis	NN
cord-001835-0s7ok4uw	4117	14	of	of	IN
cord-001835-0s7ok4uw	4117	15	local	local	JJ
cord-001835-0s7ok4uw	4117	16	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	4117	17	structural	structural	JJ
cord-001835-0s7ok4uw	4117	18	motifs	motif	NNS
cord-001835-0s7ok4uw	4117	19	(	(	-LRB-
cord-001835-0s7ok4uw	4117	20	TERM	term	NN
cord-001835-0s7ok4uw	4117	21	)	)	-RRB-
cord-001835-0s7ok4uw	4117	22	.	.	.
cord-001835-0s7ok4uw	4118	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4118	2	define	define	VBP
cord-001835-0s7ok4uw	4118	3	a	a	DT
cord-001835-0s7ok4uw	4118	4	TERM	term	NN
cord-001835-0s7ok4uw	4118	5	to	to	TO
cord-001835-0s7ok4uw	4118	6	be	be	VB
cord-001835-0s7ok4uw	4118	7	the	the	DT
cord-001835-0s7ok4uw	4118	8	structural	structural	JJ
cord-001835-0s7ok4uw	4118	9	fragment	fragment	NN
cord-001835-0s7ok4uw	4118	10	that	that	WDT
cord-001835-0s7ok4uw	4118	11	captures	capture	VBZ
cord-001835-0s7ok4uw	4118	12	all	all	DT
cord-001835-0s7ok4uw	4118	13	local	local	JJ
cord-001835-0s7ok4uw	4118	14	secondary	secondary	JJ
cord-001835-0s7ok4uw	4118	15	and	and	CC
cord-001835-0s7ok4uw	4118	16	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	4118	17	structural	structural	JJ
cord-001835-0s7ok4uw	4118	18	environments	environment	NNS
cord-001835-0s7ok4uw	4118	19	of	of	IN
cord-001835-0s7ok4uw	4118	20	a	a	DT
cord-001835-0s7ok4uw	4118	21	given	give	VBN
cord-001835-0s7ok4uw	4118	22	residue	residue	NN
cord-001835-0s7ok4uw	4118	23	,	,	,
cord-001835-0s7ok4uw	4118	24	and	and	CC
cord-001835-0s7ok4uw	4118	25	query	query	VB
cord-001835-0s7ok4uw	4118	26	the	the	DT
cord-001835-0s7ok4uw	4118	27	PDB	PDB	NNP
cord-001835-0s7ok4uw	4118	28	to	to	TO
cord-001835-0s7ok4uw	4118	29	obtain	obtain	VB
cord-001835-0s7ok4uw	4118	30	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	4118	31	information	information	NN
cord-001835-0s7ok4uw	4118	32	for	for	IN
cord-001835-0s7ok4uw	4118	33	each	each	DT
cord-001835-0s7ok4uw	4118	34	TERMs	term	NNS
cord-001835-0s7ok4uw	4118	35	.	.	.
cord-001835-0s7ok4uw	4119	1	First	first	RB
cord-001835-0s7ok4uw	4119	2	,	,	,
cord-001835-0s7ok4uw	4119	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4119	4	show	show	VBP
cord-001835-0s7ok4uw	4119	5	that	that	IN
cord-001835-0s7ok4uw	4119	6	by	by	IN
cord-001835-0s7ok4uw	4119	7	breaking	break	VBG
cord-001835-0s7ok4uw	4119	8	a	a	DT
cord-001835-0s7ok4uw	4119	9	protein	protein	NN
cord-001835-0s7ok4uw	4119	10	structure	structure	NN
cord-001835-0s7ok4uw	4119	11	into	into	IN
cord-001835-0s7ok4uw	4119	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4119	13	constituent	constituent	NN
cord-001835-0s7ok4uw	4119	14	TERMs	term	NNS
cord-001835-0s7ok4uw	4119	15	,	,	,
cord-001835-0s7ok4uw	4119	16	we	-PRON-	PRP
cord-001835-0s7ok4uw	4119	17	can	can	MD
cord-001835-0s7ok4uw	4119	18	describe	describe	VB
cord-001835-0s7ok4uw	4119	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4119	20	sequence	sequence	NN
cord-001835-0s7ok4uw	4119	21	-	-	HYPH
cord-001835-0s7ok4uw	4119	22	structure	structure	NN
cord-001835-0s7ok4uw	4119	23	relationship	relationship	NN
cord-001835-0s7ok4uw	4119	24	via	via	IN
cord-001835-0s7ok4uw	4119	25	a	a	DT
cord-001835-0s7ok4uw	4119	26	new	new	JJ
cord-001835-0s7ok4uw	4119	27	metric	metric	NN
cord-001835-0s7ok4uw	4119	28	we	-PRON-	PRP
cord-001835-0s7ok4uw	4119	29	call	call	VBP
cord-001835-0s7ok4uw	4119	30	"	"	''
cord-001835-0s7ok4uw	4119	31	structure	structure	NN
cord-001835-0s7ok4uw	4119	32	score	score	NN
cord-001835-0s7ok4uw	4119	33	.	.	.
cord-001835-0s7ok4uw	4119	34	"	"	''
cord-001835-0s7ok4uw	4120	1	Using	use	VBG
cord-001835-0s7ok4uw	4120	2	submissions	submission	NNS
cord-001835-0s7ok4uw	4120	3	in	in	IN
cord-001835-0s7ok4uw	4120	4	recent	recent	JJ
cord-001835-0s7ok4uw	4120	5	Critical	Critical	NNP
cord-001835-0s7ok4uw	4120	6	Assessment	Assessment	NNP
cord-001835-0s7ok4uw	4120	7	of	of	IN
cord-001835-0s7ok4uw	4120	8	Structure	Structure	NNP
cord-001835-0s7ok4uw	4120	9	Prediction	Prediction	NNP
cord-001835-0s7ok4uw	4120	10	(	(	-LRB-
cord-001835-0s7ok4uw	4120	11	CASP	CASP	NNP
cord-001835-0s7ok4uw	4120	12	)	)	-RRB-
cord-001835-0s7ok4uw	4120	13	experiments	experiment	NNS
cord-001835-0s7ok4uw	4120	14	,	,	,
cord-001835-0s7ok4uw	4120	15	we	-PRON-	PRP
cord-001835-0s7ok4uw	4120	16	find	find	VBP
cord-001835-0s7ok4uw	4120	17	a	a	DT
cord-001835-0s7ok4uw	4120	18	strong	strong	JJ
cord-001835-0s7ok4uw	4120	19	correlation	correlation	NN
cord-001835-0s7ok4uw	4120	20	(	(	-LRB-
cord-001835-0s7ok4uw	4120	21	R	r	NN
cord-001835-0s7ok4uw	4120	22	5	5	CD
cord-001835-0s7ok4uw	4120	23	0.69	0.69	CD
cord-001835-0s7ok4uw	4120	24	)	)	-RRB-
cord-001835-0s7ok4uw	4120	25	between	between	IN
cord-001835-0s7ok4uw	4120	26	structure	structure	NN
cord-001835-0s7ok4uw	4120	27	score	score	NN
cord-001835-0s7ok4uw	4120	28	and	and	CC
cord-001835-0s7ok4uw	4120	29	model	model	NN
cord-001835-0s7ok4uw	4120	30	accuracy	accuracy	NN
cord-001835-0s7ok4uw	4120	31	-a	-a	HYPH
cord-001835-0s7ok4uw	4120	32	performance	performance	NN
cord-001835-0s7ok4uw	4120	33	that	that	WDT
cord-001835-0s7ok4uw	4120	34	exceeds	exceed	VBZ
cord-001835-0s7ok4uw	4120	35	leading	lead	VBG
cord-001835-0s7ok4uw	4120	36	atomistic	atomistic	JJ
cord-001835-0s7ok4uw	4120	37	statistical	statistical	JJ
cord-001835-0s7ok4uw	4120	38	energy	energy	NN
cord-001835-0s7ok4uw	4120	39	functions	function	NNS
cord-001835-0s7ok4uw	4120	40	.	.	.
cord-001835-0s7ok4uw	4121	1	Next	next	RB
cord-001835-0s7ok4uw	4121	2	,	,	,
cord-001835-0s7ok4uw	4121	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4121	4	show	show	VBP
cord-001835-0s7ok4uw	4121	5	that	that	IN
cord-001835-0s7ok4uw	4121	6	querying	query	VBG
cord-001835-0s7ok4uw	4121	7	TERMs	term	NNS
cord-001835-0s7ok4uw	4121	8	affected	affect	VBN
cord-001835-0s7ok4uw	4121	9	by	by	IN
cord-001835-0s7ok4uw	4121	10	point	point	NN
cord-001835-0s7ok4uw	4121	11	mutations	mutation	NNS
cord-001835-0s7ok4uw	4121	12	enables	enable	VBZ
cord-001835-0s7ok4uw	4121	13	the	the	DT
cord-001835-0s7ok4uw	4121	14	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	4121	15	prediction	prediction	NN
cord-001835-0s7ok4uw	4121	16	of	of	IN
cord-001835-0s7ok4uw	4121	17	mutational	mutational	JJ
cord-001835-0s7ok4uw	4121	18	free	free	JJ
cord-001835-0s7ok4uw	4121	19	energies	energy	NNS
cord-001835-0s7ok4uw	4121	20	.	.	.
cord-001835-0s7ok4uw	4122	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4122	2	simple	simple	JJ
cord-001835-0s7ok4uw	4122	3	approach	approach	NN
cord-001835-0s7ok4uw	4122	4	performs	perform	VBZ
cord-001835-0s7ok4uw	4122	5	on	on	IN
cord-001835-0s7ok4uw	4122	6	par	par	NN
cord-001835-0s7ok4uw	4122	7	with	with	IN
cord-001835-0s7ok4uw	4122	8	state	state	NN
cord-001835-0s7ok4uw	4122	9	-	-	HYPH
cord-001835-0s7ok4uw	4122	10	of	of	IN
cord-001835-0s7ok4uw	4122	11	-	-	HYPH
cord-001835-0s7ok4uw	4122	12	the	the	DT
cord-001835-0s7ok4uw	4122	13	-	-	HYPH
cord-001835-0s7ok4uw	4122	14	art	art	NN
cord-001835-0s7ok4uw	4122	15	methods	method	NNS
cord-001835-0s7ok4uw	4122	16	Fold	fold	VB
cord-001835-0s7ok4uw	4122	17	-	-	HYPH
cord-001835-0s7ok4uw	4122	18	X	x	NN
cord-001835-0s7ok4uw	4122	19	and	and	CC
cord-001835-0s7ok4uw	4122	20	PoPMuSiC	popmusic	NN
cord-001835-0s7ok4uw	4122	21	on	on	IN
cord-001835-0s7ok4uw	4122	22	1300	1300	CD
cord-001835-0s7ok4uw	4122	23	mutations	mutation	NNS
cord-001835-0s7ok4uw	4122	24	,	,	,
cord-001835-0s7ok4uw	4122	25	and	and	CC
cord-001835-0s7ok4uw	4122	26	provides	provide	VBZ
cord-001835-0s7ok4uw	4122	27	superior	superior	JJ
cord-001835-0s7ok4uw	4122	28	predictions	prediction	NNS
cord-001835-0s7ok4uw	4122	29	in	in	IN
cord-001835-0s7ok4uw	4122	30	certain	certain	JJ
cord-001835-0s7ok4uw	4122	31	cases	case	NNS
cord-001835-0s7ok4uw	4122	32	where	where	WRB
cord-001835-0s7ok4uw	4122	33	other	other	JJ
cord-001835-0s7ok4uw	4122	34	methods	method	NNS
cord-001835-0s7ok4uw	4122	35	tend	tend	VBP
cord-001835-0s7ok4uw	4122	36	to	to	TO
cord-001835-0s7ok4uw	4122	37	fail	fail	VB
cord-001835-0s7ok4uw	4122	38	.	.	.
cord-001835-0s7ok4uw	4123	1	In	in	IN
cord-001835-0s7ok4uw	4123	2	all	all	DT
cord-001835-0s7ok4uw	4123	3	,	,	,
cord-001835-0s7ok4uw	4123	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4123	5	results	result	NNS
cord-001835-0s7ok4uw	4123	6	suggest	suggest	VBP
cord-001835-0s7ok4uw	4123	7	that	that	IN
cord-001835-0s7ok4uw	4123	8	the	the	DT
cord-001835-0s7ok4uw	4123	9	data	datum	NNS
cord-001835-0s7ok4uw	4123	10	available	available	JJ
cord-001835-0s7ok4uw	4123	11	in	in	IN
cord-001835-0s7ok4uw	4123	12	the	the	DT
cord-001835-0s7ok4uw	4123	13	PDB	PDB	NNP
cord-001835-0s7ok4uw	4123	14	are	be	VBP
cord-001835-0s7ok4uw	4123	15	now	now	RB
cord-001835-0s7ok4uw	4123	16	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	4123	17	to	to	TO
cord-001835-0s7ok4uw	4123	18	enable	enable	VB
cord-001835-0s7ok4uw	4123	19	the	the	DT
cord-001835-0s7ok4uw	4123	20	quantification	quantification	NN
cord-001835-0s7ok4uw	4123	21	of	of	IN
cord-001835-0s7ok4uw	4123	22	much	much	RB
cord-001835-0s7ok4uw	4123	23	more	more	RBR
cord-001835-0s7ok4uw	4123	24	sophisticated	sophisticated	JJ
cord-001835-0s7ok4uw	4123	25	structural	structural	JJ
cord-001835-0s7ok4uw	4123	26	observations	observation	NNS
cord-001835-0s7ok4uw	4123	27	,	,	,
cord-001835-0s7ok4uw	4123	28	such	such	JJ
cord-001835-0s7ok4uw	4123	29	as	as	IN
cord-001835-0s7ok4uw	4123	30	those	those	DT
cord-001835-0s7ok4uw	4123	31	associated	associate	VBN
cord-001835-0s7ok4uw	4123	32	with	with	IN
cord-001835-0s7ok4uw	4123	33	entire	entire	JJ
cord-001835-0s7ok4uw	4123	34	TERMs	term	NNS
cord-001835-0s7ok4uw	4123	35	,	,	,
cord-001835-0s7ok4uw	4123	36	which	which	WDT
cord-001835-0s7ok4uw	4123	37	should	should	MD
cord-001835-0s7ok4uw	4123	38	present	present	VB
cord-001835-0s7ok4uw	4123	39	opportunities	opportunity	NNS
cord-001835-0s7ok4uw	4123	40	for	for	IN
cord-001835-0s7ok4uw	4123	41	advances	advance	NNS
cord-001835-0s7ok4uw	4123	42	in	in	IN
cord-001835-0s7ok4uw	4123	43	computational	computational	JJ
cord-001835-0s7ok4uw	4123	44	structural	structural	JJ
cord-001835-0s7ok4uw	4123	45	biology	biology	NN
cord-001835-0s7ok4uw	4123	46	techniques	technique	NNS
cord-001835-0s7ok4uw	4123	47	,	,	,
cord-001835-0s7ok4uw	4123	48	including	include	VBG
cord-001835-0s7ok4uw	4123	49	structure	structure	NN
cord-001835-0s7ok4uw	4123	50	prediction	prediction	NN
cord-001835-0s7ok4uw	4123	51	and	and	CC
cord-001835-0s7ok4uw	4123	52	design	design	NN
cord-001835-0s7ok4uw	4123	53	.	.	.
cord-001835-0s7ok4uw	4124	1	Exploiting	exploit	VBG
cord-001835-0s7ok4uw	4124	2	natural	natural	JJ
cord-001835-0s7ok4uw	4124	3	sequence	sequence	NN
cord-001835-0s7ok4uw	4124	4	diversity	diversity	NN
cord-001835-0s7ok4uw	4124	5	for	for	IN
cord-001835-0s7ok4uw	4124	6	protein	protein	NN
cord-001835-0s7ok4uw	4124	7	crystallization	crystallization	NN
cord-001835-0s7ok4uw	4124	8	Sergio	Sergio	NNP
cord-001835-0s7ok4uw	4124	9	Mart	Mart	NNP
cord-001835-0s7ok4uw	4124	10	ınez	ınez	NN
cord-001835-0s7ok4uw	4124	11	-	-	HYPH
cord-001835-0s7ok4uw	4124	12	Rodr	Rodr	NNP
cord-001835-0s7ok4uw	4124	13	ıguez	ıguez	NNP
cord-001835-0s7ok4uw	4124	14	1	1	CD
cord-001835-0s7ok4uw	4124	15	,	,	,
cord-001835-0s7ok4uw	4124	16	Valeria	Valeria	NNP
cord-001835-0s7ok4uw	4124	17	Risso	Risso	NNP
cord-001835-0s7ok4uw	4124	18	1	1	CD
cord-001835-0s7ok4uw	4124	19	,	,	,
cord-001835-0s7ok4uw	4124	20	Jos	Jos	NNP
cord-001835-0s7ok4uw	4124	21	e	e	NNP
cord-001835-0s7ok4uw	4124	22	M	M	NNP
cord-001835-0s7ok4uw	4124	23	Sanchez	Sanchez	NNP
cord-001835-0s7ok4uw	4124	24	-	-	HYPH
cord-001835-0s7ok4uw	4124	25	Ruiz	Ruiz	NNP
cord-001835-0s7ok4uw	4124	26	1	1	CD
cord-001835-0s7ok4uw	4124	27	,	,	,
cord-001835-0s7ok4uw	4124	28	Jos	Jos	NNP
cord-001835-0s7ok4uw	4124	29	e	e	NN
cord-001835-0s7ok4uw	4124	30	A.	a.	NN
cord-001835-0s7ok4uw	4124	31	Gavira	Gavira	NNP
cord-001835-0s7ok4uw	4124	32	2	2	CD
cord-001835-0s7ok4uw	4124	33	,	,	,
cord-001835-0s7ok4uw	4124	34	1	1	CD
cord-001835-0s7ok4uw	4124	35	Departamento	Departamento	NNP
cord-001835-0s7ok4uw	4124	36	De	De	NNP
cord-001835-0s7ok4uw	4124	37	Qu	Qu	NNP
cord-001835-0s7ok4uw	4124	38	ımica	ımica	NNP
cord-001835-0s7ok4uw	4124	39	-	-	HYPH
cord-001835-0s7ok4uw	4124	40	F	F	NNP
cord-001835-0s7ok4uw	4124	41	ısica	ısica	NNP
cord-001835-0s7ok4uw	4124	42	,	,	,
cord-001835-0s7ok4uw	4124	43	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	4124	44	De	De	NNP
cord-001835-0s7ok4uw	4124	45	Granada	Granada	NNP
cord-001835-0s7ok4uw	4124	46	,	,	,
cord-001835-0s7ok4uw	4125	1	2	2	LS
cord-001835-0s7ok4uw	4125	2	Laboratorio	Laboratorio	NNP
cord-001835-0s7ok4uw	4125	3	De	De	NNP
cord-001835-0s7ok4uw	4125	4	Estudios	Estudios	NNP
cord-001835-0s7ok4uw	4125	5	Cristalogr	Cristalogr	NNP
cord-001835-0s7ok4uw	4125	6	aficos	aficos	NNP
cord-001835-0s7ok4uw	4126	1	,	,	,
cord-001835-0s7ok4uw	4126	2	IACT	IACT	NNP
cord-001835-0s7ok4uw	4126	3	-	-	HYPH
cord-001835-0s7ok4uw	4126	4	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	4126	5	-	-	HYPH
cord-001835-0s7ok4uw	4126	6	UGR	UGR	NNP
cord-001835-0s7ok4uw	4126	7	Granada	Granada	NNP
cord-001835-0s7ok4uw	4126	8	During	during	IN
cord-001835-0s7ok4uw	4126	9	the	the	DT
cord-001835-0s7ok4uw	4126	10	last	last	JJ
cord-001835-0s7ok4uw	4126	11	decade	decade	NN
cord-001835-0s7ok4uw	4126	12	,	,	,
cord-001835-0s7ok4uw	4126	13	different	different	JJ
cord-001835-0s7ok4uw	4126	14	rational	rational	JJ
cord-001835-0s7ok4uw	4126	15	and	and	CC
cord-001835-0s7ok4uw	4126	16	high	high	JJ
cord-001835-0s7ok4uw	4126	17	-	-	HYPH
cord-001835-0s7ok4uw	4126	18	throughput	throughput	NN
cord-001835-0s7ok4uw	4126	19	approaches	approach	NNS
cord-001835-0s7ok4uw	4126	20	have	have	VBP
cord-001835-0s7ok4uw	4126	21	been	be	VBN
cord-001835-0s7ok4uw	4126	22	successfully	successfully	RB
cord-001835-0s7ok4uw	4126	23	applied	apply	VBN
cord-001835-0s7ok4uw	4126	24	in	in	IN
cord-001835-0s7ok4uw	4126	25	the	the	DT
cord-001835-0s7ok4uw	4126	26	protein	protein	NN
cord-001835-0s7ok4uw	4126	27	crystallography	crystallography	NN
cord-001835-0s7ok4uw	4126	28	field	field	NN
cord-001835-0s7ok4uw	4126	29	to	to	TO
cord-001835-0s7ok4uw	4126	30	widen	widen	VB
cord-001835-0s7ok4uw	4126	31	thejjso	thejjso	NNP
cord-001835-0s7ok4uw	4126	32	-	-	HYPH
cord-001835-0s7ok4uw	4126	33	called	call	VBN
cord-001835-0s7ok4uw	4126	34	"	"	``
cord-001835-0s7ok4uw	4126	35	protein	protein	NN
cord-001835-0s7ok4uw	4126	36	crystallization	crystallization	NN
cord-001835-0s7ok4uw	4126	37	bottleneck	bottleneck	NN
cord-001835-0s7ok4uw	4126	38	"	"	''
cord-001835-0s7ok4uw	4126	39	[	[	-LRB-
cord-001835-0s7ok4uw	4126	40	1	1	CD
cord-001835-0s7ok4uw	4126	41	,	,	,
cord-001835-0s7ok4uw	4126	42	2	2	CD
cord-001835-0s7ok4uw	4126	43	]	]	-RRB-
cord-001835-0s7ok4uw	4126	44	.	.	.
cord-001835-0s7ok4uw	4127	1	Despite	despite	IN
cord-001835-0s7ok4uw	4127	2	the	the	DT
cord-001835-0s7ok4uw	4127	3	enormous	enormous	JJ
cord-001835-0s7ok4uw	4127	4	efforts	effort	NNS
cord-001835-0s7ok4uw	4127	5	carried	carry	VBN
cord-001835-0s7ok4uw	4127	6	out	out	RP
cord-001835-0s7ok4uw	4127	7	by	by	IN
cord-001835-0s7ok4uw	4127	8	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4127	9	community	community	NN
cord-001835-0s7ok4uw	4127	10	,	,	,
cord-001835-0s7ok4uw	4127	11	the	the	DT
cord-001835-0s7ok4uw	4127	12	statistics	statistic	NNS
cord-001835-0s7ok4uw	4127	13	presented	present	VBN
cord-001835-0s7ok4uw	4127	14	by	by	IN
cord-001835-0s7ok4uw	4127	15	Structural	Structural	NNP
cord-001835-0s7ok4uw	4127	16	Biology	Biology	NNP
cord-001835-0s7ok4uw	4127	17	Consortiums	Consortiums	NNPS
cord-001835-0s7ok4uw	4127	18	[	[	-LRB-
cord-001835-0s7ok4uw	4127	19	3	3	CD
cord-001835-0s7ok4uw	4127	20	]	]	-RRB-
cord-001835-0s7ok4uw	4127	21	suggest	suggest	VBP
cord-001835-0s7ok4uw	4127	22	that	that	IN
cord-001835-0s7ok4uw	4127	23	so	so	RB
cord-001835-0s7ok4uw	4127	24	far	far	RB
cord-001835-0s7ok4uw	4127	25	only	only	RB
cord-001835-0s7ok4uw	4127	26	the	the	DT
cord-001835-0s7ok4uw	4127	27	easy	easy	JJ
cord-001835-0s7ok4uw	4127	28	-	-	HYPH
cord-001835-0s7ok4uw	4127	29	to	to	TO
cord-001835-0s7ok4uw	4127	30	-	-	HYPH
cord-001835-0s7ok4uw	4127	31	pick	pick	NN
cord-001835-0s7ok4uw	4127	32	fruit	fruit	NN
cord-001835-0s7ok4uw	4127	33	has	have	VBZ
cord-001835-0s7ok4uw	4127	34	been	be	VBN
cord-001835-0s7ok4uw	4127	35	attained	attain	VBN
cord-001835-0s7ok4uw	4127	36	;	;	:
cord-001835-0s7ok4uw	4127	37	thus	thus	RB
cord-001835-0s7ok4uw	4127	38	,	,	,
cord-001835-0s7ok4uw	4127	39	new	new	JJ
cord-001835-0s7ok4uw	4127	40	approaches	approach	NNS
cord-001835-0s7ok4uw	4127	41	are	be	VBP
cord-001835-0s7ok4uw	4127	42	necessary	necessary	JJ
cord-001835-0s7ok4uw	4127	43	to	to	TO
cord-001835-0s7ok4uw	4127	44	further	further	RB
cord-001835-0s7ok4uw	4127	45	expand	expand	VB
cord-001835-0s7ok4uw	4127	46	the	the	DT
cord-001835-0s7ok4uw	4127	47	crystallization	crystallization	NN
cord-001835-0s7ok4uw	4127	48	limiting	limit	VBG
cord-001835-0s7ok4uw	4127	49	step	step	NN
cord-001835-0s7ok4uw	4127	50	to	to	IN
cord-001835-0s7ok4uw	4127	51	relevant	relevant	JJ
cord-001835-0s7ok4uw	4127	52	targets	target	NNS
cord-001835-0s7ok4uw	4127	53	.	.	.
cord-001835-0s7ok4uw	4128	1	On	on	IN
cord-001835-0s7ok4uw	4128	2	the	the	DT
cord-001835-0s7ok4uw	4128	3	basis	basis	NN
cord-001835-0s7ok4uw	4128	4	of	of	IN
cord-001835-0s7ok4uw	4128	5	previous	previous	JJ
cord-001835-0s7ok4uw	4128	6	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	4128	7	suggesting	suggest	VBG
cord-001835-0s7ok4uw	4128	8	that	that	IN
cord-001835-0s7ok4uw	4128	9	the	the	DT
cord-001835-0s7ok4uw	4128	10	difficulties	difficulty	NNS
cord-001835-0s7ok4uw	4128	11	found	find	VBN
cord-001835-0s7ok4uw	4128	12	in	in	IN
cord-001835-0s7ok4uw	4128	13	protein	protein	NN
cord-001835-0s7ok4uw	4128	14	crystallization	crystallization	NN
cord-001835-0s7ok4uw	4128	15	might	may	MD
cord-001835-0s7ok4uw	4128	16	be	be	VB
cord-001835-0s7ok4uw	4128	17	a	a	DT
cord-001835-0s7ok4uw	4128	18	result	result	NN
cord-001835-0s7ok4uw	4128	19	of	of	IN
cord-001835-0s7ok4uw	4128	20	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	4128	21	negative	negative	JJ
cord-001835-0s7ok4uw	4128	22	design	design	NN
cord-001835-0s7ok4uw	4128	23	[	[	-LRB-
cord-001835-0s7ok4uw	4128	24	4	4	CD
cord-001835-0s7ok4uw	4128	25	]	]	-RRB-
cord-001835-0s7ok4uw	4128	26	,	,	,
cord-001835-0s7ok4uw	4128	27	we	-PRON-	PRP
cord-001835-0s7ok4uw	4128	28	have	have	VBP
cord-001835-0s7ok4uw	4128	29	used	use	VBN
cord-001835-0s7ok4uw	4128	30	two	two	CD
cord-001835-0s7ok4uw	4128	31	different	different	JJ
cord-001835-0s7ok4uw	4128	32	protein	protein	NN
cord-001835-0s7ok4uw	4128	33	engineering	engineering	NN
cord-001835-0s7ok4uw	4128	34	approaches	approach	NNS
cord-001835-0s7ok4uw	4128	35	exploiting	exploit	VBG
cord-001835-0s7ok4uw	4128	36	natural	natural	JJ
cord-001835-0s7ok4uw	4128	37	sequence	sequence	NN
cord-001835-0s7ok4uw	4128	38	diversity	diversity	NN
cord-001835-0s7ok4uw	4128	39	using	use	VBG
cord-001835-0s7ok4uw	4128	40	beta	beta	NN
cord-001835-0s7ok4uw	4128	41	-	-	HYPH
cord-001835-0s7ok4uw	4128	42	lactamase	lactamase	NN
cord-001835-0s7ok4uw	4128	43	as	as	IN
cord-001835-0s7ok4uw	4128	44	toolbox	toolbox	NN
cord-001835-0s7ok4uw	4128	45	:	:	:
cord-001835-0s7ok4uw	4128	46	i	i	LS
cord-001835-0s7ok4uw	4128	47	)	)	-RRB-
cord-001835-0s7ok4uw	4128	48	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	4128	49	reconstruction	reconstruction	NN
cord-001835-0s7ok4uw	4128	50	and	and	CC
cord-001835-0s7ok4uw	4128	51	ii	ii	NNP
cord-001835-0s7ok4uw	4128	52	)	)	-RRB-
cord-001835-0s7ok4uw	4128	53	consensus	consensus	NN
cord-001835-0s7ok4uw	4128	54	approach	approach	NN
cord-001835-0s7ok4uw	4128	55	[	[	-LRB-
cord-001835-0s7ok4uw	4128	56	5	5	CD
cord-001835-0s7ok4uw	4128	57	]	]	-RRB-
cord-001835-0s7ok4uw	4128	58	.	.	.
cord-001835-0s7ok4uw	4129	1	Both	both	DT
cord-001835-0s7ok4uw	4129	2	approaches	approach	NNS
cord-001835-0s7ok4uw	4129	3	resulted	result	VBD
cord-001835-0s7ok4uw	4129	4	in	in	IN
cord-001835-0s7ok4uw	4129	5	hyperstable	hyperstable	JJ
cord-001835-0s7ok4uw	4129	6	and	and	CC
cord-001835-0s7ok4uw	4129	7	promiscuous	promiscuous	JJ
cord-001835-0s7ok4uw	4129	8	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	4129	9	derivatives	derivative	NNS
cord-001835-0s7ok4uw	4129	10	.	.	.
cord-001835-0s7ok4uw	4130	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	4130	2	,	,	,
cord-001835-0s7ok4uw	4130	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4130	4	initial	initial	JJ
cord-001835-0s7ok4uw	4130	5	crystallization	crystallization	NN
cord-001835-0s7ok4uw	4130	6	results	result	NNS
cord-001835-0s7ok4uw	4130	7	also	also	RB
cord-001835-0s7ok4uw	4130	8	suggest	suggest	VBP
cord-001835-0s7ok4uw	4130	9	that	that	IN
cord-001835-0s7ok4uw	4130	10	both	both	DT
cord-001835-0s7ok4uw	4130	11	approaches	approach	NNS
cord-001835-0s7ok4uw	4130	12	increased	increase	VBD
cord-001835-0s7ok4uw	4130	13	the	the	DT
cord-001835-0s7ok4uw	4130	14	crystallizability	crystallizability	NN
cord-001835-0s7ok4uw	4130	15	of	of	IN
cord-001835-0s7ok4uw	4130	16	the	the	DT
cord-001835-0s7ok4uw	4130	17	resulting	result	VBG
cord-001835-0s7ok4uw	4130	18	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4130	19	when	when	WRB
cord-001835-0s7ok4uw	4130	20	compared	compare	VBN
cord-001835-0s7ok4uw	4130	21	to	to	IN
cord-001835-0s7ok4uw	4130	22	the	the	DT
cord-001835-0s7ok4uw	4130	23	extant	extant	JJ
cord-001835-0s7ok4uw	4130	24	TEM-1	tem-1	CD
cord-001835-0s7ok4uw	4130	25	beta	beta	NN
cord-001835-0s7ok4uw	4130	26	-	-	HYPH
cord-001835-0s7ok4uw	4130	27	lactamase	lactamase	NN
cord-001835-0s7ok4uw	4130	28	.	.	.
cord-001835-0s7ok4uw	4130	29	 	 	_SP
cord-001835-0s7ok4uw	4131	1	The	the	DT
cord-001835-0s7ok4uw	4131	2	adipocyte	adipocyte	NN
cord-001835-0s7ok4uw	4131	3	-	-	HYPH
cord-001835-0s7ok4uw	4131	4	derived	derive	VBN
cord-001835-0s7ok4uw	4131	5	hormone	hormone	NN
cord-001835-0s7ok4uw	4131	6	adiponectin	adiponectin	NN
cord-001835-0s7ok4uw	4131	7	has	have	VBZ
cord-001835-0s7ok4uw	4131	8	become	become	VBN
cord-001835-0s7ok4uw	4131	9	a	a	DT
cord-001835-0s7ok4uw	4131	10	key	key	JJ
cord-001835-0s7ok4uw	4131	11	player	player	NN
cord-001835-0s7ok4uw	4131	12	for	for	IN
cord-001835-0s7ok4uw	4131	13	the	the	DT
cord-001835-0s7ok4uw	4131	14	understanding	understanding	NN
cord-001835-0s7ok4uw	4131	15	of	of	IN
cord-001835-0s7ok4uw	4131	16	overweight	overweight	JJ
cord-001835-0s7ok4uw	4131	17	related	relate	VBN
cord-001835-0s7ok4uw	4131	18	diseases	disease	NNS
cord-001835-0s7ok4uw	4131	19	like	like	IN
cord-001835-0s7ok4uw	4131	20	obesity	obesity	NN
cord-001835-0s7ok4uw	4131	21	,	,	,
cord-001835-0s7ok4uw	4131	22	diabetes	diabetes	NN
cord-001835-0s7ok4uw	4131	23	,	,	,
cord-001835-0s7ok4uw	4131	24	atherosclerosis	atherosclerosis	NN
cord-001835-0s7ok4uw	4131	25	or	or	CC
cord-001835-0s7ok4uw	4131	26	the	the	DT
cord-001835-0s7ok4uw	4131	27	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	4131	28	syndrome	syndrome	NN
cord-001835-0s7ok4uw	4131	29	.	.	.
cord-001835-0s7ok4uw	4132	1	One	one	CD
cord-001835-0s7ok4uw	4132	2	of	of	IN
cord-001835-0s7ok4uw	4132	3	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4132	4	ABSTRACT	abstract	JJ
cord-001835-0s7ok4uw	4132	5	major	major	JJ
cord-001835-0s7ok4uw	4132	6	functions	function	NNS
cord-001835-0s7ok4uw	4132	7	are	be	VBP
cord-001835-0s7ok4uw	4132	8	the	the	DT
cord-001835-0s7ok4uw	4132	9	insulin	insulin	NN
cord-001835-0s7ok4uw	4132	10	sensitizing	sensitize	VBG
cord-001835-0s7ok4uw	4132	11	effects	effect	NNS
cord-001835-0s7ok4uw	4132	12	,	,	,
cord-001835-0s7ok4uw	4132	13	which	which	WDT
cord-001835-0s7ok4uw	4132	14	are	be	VBP
cord-001835-0s7ok4uw	4132	15	mediated	mediate	VBN
cord-001835-0s7ok4uw	4132	16	by	by	IN
cord-001835-0s7ok4uw	4132	17	the	the	DT
cord-001835-0s7ok4uw	4132	18	activation	activation	NN
cord-001835-0s7ok4uw	4132	19	of	of	IN
cord-001835-0s7ok4uw	4132	20	AMPK	AMPK	NNP
cord-001835-0s7ok4uw	4132	21	,	,	,
cord-001835-0s7ok4uw	4132	22	p38-MAPK	p38-MAPK	NNP
cord-001835-0s7ok4uw	4132	23	and	and	CC
cord-001835-0s7ok4uw	4132	24	PPARa	PPARa	NNS
cord-001835-0s7ok4uw	4132	25	(	(	-LRB-
cord-001835-0s7ok4uw	4132	26	1	1	CD
cord-001835-0s7ok4uw	4132	27	)	)	-RRB-
cord-001835-0s7ok4uw	4132	28	.	.	.
cord-001835-0s7ok4uw	4133	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	4133	2	adiponectin	adiponectin	NN
cord-001835-0s7ok4uw	4133	3	is	be	VBZ
cord-001835-0s7ok4uw	4133	4	involved	involve	VBN
cord-001835-0s7ok4uw	4133	5	into	into	IN
cord-001835-0s7ok4uw	4133	6	glucose	glucose	NN
cord-001835-0s7ok4uw	4133	7	regulation	regulation	NN
cord-001835-0s7ok4uw	4133	8	and	and	CC
cord-001835-0s7ok4uw	4133	9	fatty	fatty	JJ
cord-001835-0s7ok4uw	4133	10	acid	acid	NN
cord-001835-0s7ok4uw	4133	11	oxidation	oxidation	NN
cord-001835-0s7ok4uw	4133	12	.	.	.
cord-001835-0s7ok4uw	4134	1	Recently	recently	RB
cord-001835-0s7ok4uw	4134	2	,	,	,
cord-001835-0s7ok4uw	4134	3	three	three	CD
cord-001835-0s7ok4uw	4134	4	adiponectin	adiponectin	NN
cord-001835-0s7ok4uw	4134	5	receptors	receptor	NNS
cord-001835-0s7ok4uw	4134	6	AdipoR1	adipor1	VBP
cord-001835-0s7ok4uw	4134	7	,	,	,
cord-001835-0s7ok4uw	4134	8	AdipoR2	adipor2	NN
cord-001835-0s7ok4uw	4134	9	and	and	CC
cord-001835-0s7ok4uw	4134	10	T	t	NN
cord-001835-0s7ok4uw	4134	11	-	-	HYPH
cord-001835-0s7ok4uw	4134	12	cadherin	cadherin	NN
cord-001835-0s7ok4uw	4134	13	have	have	VBP
cord-001835-0s7ok4uw	4134	14	been	be	VBN
cord-001835-0s7ok4uw	4134	15	described	describe	VBN
cord-001835-0s7ok4uw	4134	16	while	while	IN
cord-001835-0s7ok4uw	4134	17	an	an	DT
cord-001835-0s7ok4uw	4134	18	unknown	unknown	JJ
cord-001835-0s7ok4uw	4134	19	fourth	fourth	JJ
cord-001835-0s7ok4uw	4134	20	receptor	receptor	NN
cord-001835-0s7ok4uw	4134	21	is	be	VBZ
cord-001835-0s7ok4uw	4134	22	hypothesized	hypothesize	VBN
cord-001835-0s7ok4uw	4134	23	(	(	-LRB-
cord-001835-0s7ok4uw	4134	24	2	2	CD
cord-001835-0s7ok4uw	4134	25	)	)	-RRB-
cord-001835-0s7ok4uw	4134	26	.	.	.
cord-001835-0s7ok4uw	4135	1	For	for	IN
cord-001835-0s7ok4uw	4135	2	only	only	RB
cord-001835-0s7ok4uw	4135	3	two	two	CD
cord-001835-0s7ok4uw	4135	4	of	of	IN
cord-001835-0s7ok4uw	4135	5	them	-PRON-	PRP
cord-001835-0s7ok4uw	4135	6	(	(	-LRB-
cord-001835-0s7ok4uw	4135	7	AdipoR1	adipor1	NN
cord-001835-0s7ok4uw	4135	8	and	and	CC
cord-001835-0s7ok4uw	4135	9	AdipoR2	adipor2	NN
cord-001835-0s7ok4uw	4135	10	)	)	-RRB-
cord-001835-0s7ok4uw	4136	1	the	the	DT
cord-001835-0s7ok4uw	4136	2	signaling	signal	VBG
cord-001835-0s7ok4uw	4136	3	transduction	transduction	NN
cord-001835-0s7ok4uw	4136	4	via	via	IN
cord-001835-0s7ok4uw	4136	5	adiponectin	adiponectin	NN
cord-001835-0s7ok4uw	4136	6	has	have	VBZ
cord-001835-0s7ok4uw	4136	7	been	be	VBN
cord-001835-0s7ok4uw	4136	8	confirmed	confirm	VBN
cord-001835-0s7ok4uw	4136	9	(	(	-LRB-
cord-001835-0s7ok4uw	4136	10	3	3	CD
cord-001835-0s7ok4uw	4136	11	)	)	-RRB-
cord-001835-0s7ok4uw	4136	12	.	.	.
cord-001835-0s7ok4uw	4137	1	In	in	IN
cord-001835-0s7ok4uw	4137	2	order	order	NN
cord-001835-0s7ok4uw	4137	3	to	to	TO
cord-001835-0s7ok4uw	4137	4	find	find	VB
cord-001835-0s7ok4uw	4137	5	new	new	JJ
cord-001835-0s7ok4uw	4137	6	binding	bind	VBG
cord-001835-0s7ok4uw	4137	7	partners	partner	NNS
cord-001835-0s7ok4uw	4137	8	or	or	CC
cord-001835-0s7ok4uw	4137	9	co	co	NNS
cord-001835-0s7ok4uw	4137	10	-	-	NNS
cord-001835-0s7ok4uw	4137	11	receptors	receptor	NNS
cord-001835-0s7ok4uw	4137	12	,	,	,
cord-001835-0s7ok4uw	4137	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	4137	14	cloned	clone	VBD
cord-001835-0s7ok4uw	4137	15	and	and	CC
cord-001835-0s7ok4uw	4137	16	expressed	express	VBD
cord-001835-0s7ok4uw	4137	17	full	full	JJ
cord-001835-0s7ok4uw	4137	18	length	length	NN
cord-001835-0s7ok4uw	4137	19	adiponectin	adiponectin	NN
cord-001835-0s7ok4uw	4137	20	as	as	IN
cord-001835-0s7ok4uw	4137	21	a	a	DT
cord-001835-0s7ok4uw	4137	22	fusion	fusion	NN
cord-001835-0s7ok4uw	4137	23	protein	protein	NN
cord-001835-0s7ok4uw	4137	24	with	with	IN
cord-001835-0s7ok4uw	4137	25	a	a	DT
cord-001835-0s7ok4uw	4137	26	C	C	NNP
cord-001835-0s7ok4uw	4137	27	-	-	HYPH
cord-001835-0s7ok4uw	4137	28	terminal	terminal	NN
cord-001835-0s7ok4uw	4137	29	intein	intein	NNP
cord-001835-0s7ok4uw	4137	30	and	and	CC
cord-001835-0s7ok4uw	4137	31	a	a	DT
cord-001835-0s7ok4uw	4137	32	chitin	chitin	NN
cord-001835-0s7ok4uw	4137	33	binding	bind	VBG
cord-001835-0s7ok4uw	4137	34	domain	domain	NN
cord-001835-0s7ok4uw	4137	35	(	(	-LRB-
cord-001835-0s7ok4uw	4137	36	CBD	CBD	NNP
cord-001835-0s7ok4uw	4137	37	)	)	-RRB-
cord-001835-0s7ok4uw	4137	38	as	as	RB
cord-001835-0s7ok4uw	4137	39	well	well	RB
cord-001835-0s7ok4uw	4137	40	as	as	IN
cord-001835-0s7ok4uw	4137	41	an	an	DT
cord-001835-0s7ok4uw	4137	42	N	n	CD
cord-001835-0s7ok4uw	4137	43	-	-	HYPH
cord-001835-0s7ok4uw	4137	44	terminal	terminal	NN
cord-001835-0s7ok4uw	4137	45	His10-tag	his10-tag	NN
cord-001835-0s7ok4uw	4137	46	.	.	.
cord-001835-0s7ok4uw	4138	1	By	by	IN
cord-001835-0s7ok4uw	4138	2	using	use	VBG
cord-001835-0s7ok4uw	4138	3	the	the	DT
cord-001835-0s7ok4uw	4138	4	IMPACTsystem	impactsystem	NN
cord-001835-0s7ok4uw	4138	5	,	,	,
cord-001835-0s7ok4uw	4138	6	the	the	DT
cord-001835-0s7ok4uw	4138	7	fusion	fusion	NN
cord-001835-0s7ok4uw	4138	8	protein	protein	NN
cord-001835-0s7ok4uw	4138	9	was	be	VBD
cord-001835-0s7ok4uw	4138	10	cleaved	cleave	VBN
cord-001835-0s7ok4uw	4138	11	to	to	TO
cord-001835-0s7ok4uw	4138	12	form	form	VB
cord-001835-0s7ok4uw	4138	13	the	the	DT
cord-001835-0s7ok4uw	4138	14	corresponding	correspond	VBG
cord-001835-0s7ok4uw	4138	15	thioester	thioester	NN
cord-001835-0s7ok4uw	4138	16	.	.	.
cord-001835-0s7ok4uw	4139	1	To	to	TO
cord-001835-0s7ok4uw	4139	2	separate	separate	VB
cord-001835-0s7ok4uw	4139	3	the	the	DT
cord-001835-0s7ok4uw	4139	4	starting	start	VBG
cord-001835-0s7ok4uw	4139	5	materials	material	NNS
cord-001835-0s7ok4uw	4139	6	as	as	RB
cord-001835-0s7ok4uw	4139	7	well	well	RB
cord-001835-0s7ok4uw	4139	8	as	as	IN
cord-001835-0s7ok4uw	4139	9	the	the	DT
cord-001835-0s7ok4uw	4139	10	cleaved	cleaved	JJ
cord-001835-0s7ok4uw	4139	11	intein	intein	NNP
cord-001835-0s7ok4uw	4139	12	chitin	chitin	NN
cord-001835-0s7ok4uw	4139	13	binding	bind	VBG
cord-001835-0s7ok4uw	4139	14	domain	domain	NN
cord-001835-0s7ok4uw	4139	15	,	,	,
cord-001835-0s7ok4uw	4139	16	the	the	DT
cord-001835-0s7ok4uw	4139	17	purification	purification	NN
cord-001835-0s7ok4uw	4139	18	was	be	VBD
cord-001835-0s7ok4uw	4139	19	performed	perform	VBN
cord-001835-0s7ok4uw	4139	20	with	with	IN
cord-001835-0s7ok4uw	4139	21	chitin	chitin	NN
cord-001835-0s7ok4uw	4139	22	beads	bead	NNS
cord-001835-0s7ok4uw	4139	23	.	.	.
cord-001835-0s7ok4uw	4140	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	4140	2	,	,	,
cord-001835-0s7ok4uw	4140	3	the	the	DT
cord-001835-0s7ok4uw	4140	4	product	product	NN
cord-001835-0s7ok4uw	4140	5	was	be	VBD
cord-001835-0s7ok4uw	4140	6	concentrated	concentrate	VBN
cord-001835-0s7ok4uw	4140	7	by	by	IN
cord-001835-0s7ok4uw	4140	8	Ni	Ni	NNP
cord-001835-0s7ok4uw	4140	9	-	-	HYPH
cord-001835-0s7ok4uw	4140	10	NTA	NTA	NNP
cord-001835-0s7ok4uw	4140	11	-	-	HYPH
cord-001835-0s7ok4uw	4140	12	affinity	affinity	NN
cord-001835-0s7ok4uw	4140	13	chromatography	chromatography	NN
cord-001835-0s7ok4uw	4140	14	.	.	.
cord-001835-0s7ok4uw	4141	1	Accordingly	accordingly	RB
cord-001835-0s7ok4uw	4141	2	,	,	,
cord-001835-0s7ok4uw	4141	3	the	the	DT
cord-001835-0s7ok4uw	4141	4	obtained	obtain	VBN
cord-001835-0s7ok4uw	4141	5	adiponectin	adiponectin	NN
cord-001835-0s7ok4uw	4141	6	thioester	thioester	NN
cord-001835-0s7ok4uw	4141	7	was	be	VBD
cord-001835-0s7ok4uw	4141	8	reacted	react	VBN
cord-001835-0s7ok4uw	4141	9	with	with	IN
cord-001835-0s7ok4uw	4141	10	a	a	DT
cord-001835-0s7ok4uw	4141	11	TAMRA	TAMRA	NNP
cord-001835-0s7ok4uw	4141	12	-	-	:
cord-001835-0s7ok4uw	4141	13	or	or	CC
cord-001835-0s7ok4uw	4141	14	a	a	DT
cord-001835-0s7ok4uw	4141	15	biotin	biotin	NN
cord-001835-0s7ok4uw	4141	16	labeled	label	VBN
cord-001835-0s7ok4uw	4141	17	peptide	peptide	NN
cord-001835-0s7ok4uw	4141	18	,	,	,
cord-001835-0s7ok4uw	4141	19	respectively	respectively	RB
cord-001835-0s7ok4uw	4141	20	,	,	,
cord-001835-0s7ok4uw	4141	21	to	to	TO
cord-001835-0s7ok4uw	4141	22	receive	receive	VB
cord-001835-0s7ok4uw	4141	23	the	the	DT
cord-001835-0s7ok4uw	4141	24	corresponding	correspond	VBG
cord-001835-0s7ok4uw	4141	25	ligation	ligation	NN
cord-001835-0s7ok4uw	4141	26	product	product	NN
cord-001835-0s7ok4uw	4141	27	.	.	.
cord-001835-0s7ok4uw	4142	1	Finally	finally	RB
cord-001835-0s7ok4uw	4142	2	the	the	DT
cord-001835-0s7ok4uw	4142	3	functionalized	functionalized	JJ
cord-001835-0s7ok4uw	4142	4	adiponectin	adiponectin	NN
cord-001835-0s7ok4uw	4142	5	was	be	VBD
cord-001835-0s7ok4uw	4142	6	purified	purify	VBN
cord-001835-0s7ok4uw	4142	7	by	by	IN
cord-001835-0s7ok4uw	4142	8	size	size	NN
cord-001835-0s7ok4uw	4142	9	exclusion	exclusion	NN
cord-001835-0s7ok4uw	4142	10	chromatography	chromatography	NN
cord-001835-0s7ok4uw	4142	11	.	.	.
cord-001835-0s7ok4uw	4143	1	Further	further	JJ
cord-001835-0s7ok4uw	4143	2	studies	study	NNS
cord-001835-0s7ok4uw	4143	3	will	will	MD
cord-001835-0s7ok4uw	4143	4	allow	allow	VB
cord-001835-0s7ok4uw	4143	5	screening	screening	NN
cord-001835-0s7ok4uw	4143	6	for	for	IN
cord-001835-0s7ok4uw	4143	7	interacting	interact	VBG
cord-001835-0s7ok4uw	4143	8	molecules	molecule	NNS
cord-001835-0s7ok4uw	4143	9	in	in	IN
cord-001835-0s7ok4uw	4143	10	cell	cell	NN
cord-001835-0s7ok4uw	4143	11	and	and	CC
cord-001835-0s7ok4uw	4143	12	tissue	tissue	NN
cord-001835-0s7ok4uw	4143	13	derived	derive	VBN
cord-001835-0s7ok4uw	4143	14	samples	sample	NNS
cord-001835-0s7ok4uw	4143	15	.	.	.
cord-001835-0s7ok4uw	4144	1	Departamento	Departamento	NNP
cord-001835-0s7ok4uw	4144	2	de	de	NNP
cord-001835-0s7ok4uw	4144	3	Quimica	Quimica	NNP
cord-001835-0s7ok4uw	4144	4	Fisica	Fisica	NNP
cord-001835-0s7ok4uw	4144	5	,	,	,
cord-001835-0s7ok4uw	4144	6	Facultad	Facultad	NNP
cord-001835-0s7ok4uw	4144	7	de	de	NNP
cord-001835-0s7ok4uw	4144	8	Ciencias	Ciencias	NNP
cord-001835-0s7ok4uw	4144	9	University	University	NNP
cord-001835-0s7ok4uw	4144	10	of	of	IN
cord-001835-0s7ok4uw	4144	11	Granada	Granada	NNP
cord-001835-0s7ok4uw	4144	12	,	,	,
cord-001835-0s7ok4uw	4144	13	2	2	CD
cord-001835-0s7ok4uw	4144	14	Dpto	Dpto	NNPS
cord-001835-0s7ok4uw	4144	15	.	.	.
cord-001835-0s7ok4uw	4145	1	de	de	NNP
cord-001835-0s7ok4uw	4145	2	Quimica	Quimica	NNP
cord-001835-0s7ok4uw	4145	3	Fisica	Fisica	NNP
cord-001835-0s7ok4uw	4145	4	Biologica	Biologica	NNP
cord-001835-0s7ok4uw	4145	5	.	.	.
cord-001835-0s7ok4uw	4146	1	Instituto	Instituto	NNP
cord-001835-0s7ok4uw	4146	2	de	de	NNP
cord-001835-0s7ok4uw	4146	3	Quimica	Quimica	NNP
cord-001835-0s7ok4uw	4146	4	Fisica	Fisica	NNP
cord-001835-0s7ok4uw	4146	5	Rocasolano	Rocasolano	NNP
cord-001835-0s7ok4uw	4146	6	,	,	,
cord-001835-0s7ok4uw	4146	7	3	3	CD
cord-001835-0s7ok4uw	4146	8	Departamento	Departamento	NNP
cord-001835-0s7ok4uw	4146	9	de	de	NNP
cord-001835-0s7ok4uw	4146	10	Quimica	Quimica	NNP
cord-001835-0s7ok4uw	4146	11	Organica	Organica	NNP
cord-001835-0s7ok4uw	4146	12	,	,	,
cord-001835-0s7ok4uw	4146	13	Facultad	Facultad	NNP
cord-001835-0s7ok4uw	4146	14	de	de	NNP
cord-001835-0s7ok4uw	4146	15	Ciencias	Ciencias	NNP
cord-001835-0s7ok4uw	4146	16	University	University	NNP
cord-001835-0s7ok4uw	4146	17	of	of	IN
cord-001835-0s7ok4uw	4146	18	Granada	Granada	NNP
cord-001835-0s7ok4uw	4146	19	,	,	,
cord-001835-0s7ok4uw	4146	20	4	4	CD
cord-001835-0s7ok4uw	4146	21	 	 	_SP
cord-001835-0s7ok4uw	4146	22	Rational	rational	JJ
cord-001835-0s7ok4uw	4146	23	design	design	NN
cord-001835-0s7ok4uw	4146	24	of	of	IN
cord-001835-0s7ok4uw	4146	25	non	non	JJ
cord-001835-0s7ok4uw	4146	26	-	-	JJ
cord-001835-0s7ok4uw	4146	27	natural	natural	JJ
cord-001835-0s7ok4uw	4146	28	enzyme	enzyme	NN
cord-001835-0s7ok4uw	4146	29	activities	activity	NNS
cord-001835-0s7ok4uw	4146	30	has	have	VBZ
cord-001835-0s7ok4uw	4146	31	proved	prove	VBN
cord-001835-0s7ok4uw	4146	32	challenging	challenging	JJ
cord-001835-0s7ok4uw	4146	33	.	.	.
cord-001835-0s7ok4uw	4147	1	Here	here	RB
cord-001835-0s7ok4uw	4147	2	,	,	,
cord-001835-0s7ok4uw	4147	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4147	4	report	report	VBP
cord-001835-0s7ok4uw	4147	5	the	the	DT
cord-001835-0s7ok4uw	4147	6	introduction	introduction	NN
cord-001835-0s7ok4uw	4147	7	of	of	IN
cord-001835-0s7ok4uw	4147	8	catalysis	catalysis	NN
cord-001835-0s7ok4uw	4147	9	of	of	IN
cord-001835-0s7ok4uw	4147	10	the	the	DT
cord-001835-0s7ok4uw	4147	11	Kemp	Kemp	NNP
cord-001835-0s7ok4uw	4147	12	elimination	elimination	NN
cord-001835-0s7ok4uw	4147	13	(	(	-LRB-
cord-001835-0s7ok4uw	4147	14	a	a	DT
cord-001835-0s7ok4uw	4147	15	model	model	NN
cord-001835-0s7ok4uw	4147	16	of	of	IN
cord-001835-0s7ok4uw	4147	17	proton	proton	NN
cord-001835-0s7ok4uw	4147	18	abstraction	abstraction	NN
cord-001835-0s7ok4uw	4147	19	from	from	IN
cord-001835-0s7ok4uw	4147	20	carbon	carbon	NN
cord-001835-0s7ok4uw	4147	21	)	)	-RRB-
cord-001835-0s7ok4uw	4147	22	in	in	IN
cord-001835-0s7ok4uw	4147	23	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	4147	24	corresponding	correspond	VBG
cord-001835-0s7ok4uw	4147	25	to	to	IN
cord-001835-0s7ok4uw	4147	26	Precambrian	precambrian	JJ
cord-001835-0s7ok4uw	4147	27	nodes	node	NNS
cord-001835-0s7ok4uw	4147	28	in	in	IN
cord-001835-0s7ok4uw	4147	29	the	the	DT
cord-001835-0s7ok4uw	4147	30	evolution	evolution	NN
cord-001835-0s7ok4uw	4147	31	of	of	IN
cord-001835-0s7ok4uw	4147	32	the	the	DT
cord-001835-0s7ok4uw	4147	33	antibiotic	antibiotic	JJ
cord-001835-0s7ok4uw	4147	34	resistance	resistance	NN
cord-001835-0s7ok4uw	4147	35	protein	protein	NN
cord-001835-0s7ok4uw	4147	36	b	b	NN
cord-001835-0s7ok4uw	4147	37	-	-	:
cord-001835-0s7ok4uw	4147	38	lactamase	lactamase	NN
cord-001835-0s7ok4uw	4147	39	.	.	.
cord-001835-0s7ok4uw	4148	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4148	2	used	use	VBD
cord-001835-0s7ok4uw	4148	3	a	a	DT
cord-001835-0s7ok4uw	4148	4	single	single	JJ
cord-001835-0s7ok4uw	4148	5	-	-	HYPH
cord-001835-0s7ok4uw	4148	6	mutation	mutation	NN
cord-001835-0s7ok4uw	4148	7	,	,	,
cord-001835-0s7ok4uw	4148	8	minimalist	minimalist	JJ
cord-001835-0s7ok4uw	4148	9	approach	approach	NN
cord-001835-0s7ok4uw	4148	10	based	base	VBN
cord-001835-0s7ok4uw	4148	11	on	on	IN
cord-001835-0s7ok4uw	4148	12	chemical	chemical	JJ
cord-001835-0s7ok4uw	4148	13	intuition	intuition	NN
cord-001835-0s7ok4uw	4148	14	,	,	,
cord-001835-0s7ok4uw	4148	15	and	and	CC
cord-001835-0s7ok4uw	4148	16	obtained	obtain	VBD
cord-001835-0s7ok4uw	4148	17	catalysis	catalysis	NN
cord-001835-0s7ok4uw	4148	18	levels	level	NNS
cord-001835-0s7ok4uw	4148	19	similar	similar	JJ
cord-001835-0s7ok4uw	4148	20	to	to	IN
cord-001835-0s7ok4uw	4148	21	those	those	DT
cord-001835-0s7ok4uw	4148	22	reported	report	VBN
cord-001835-0s7ok4uw	4148	23	in	in	IN
cord-001835-0s7ok4uw	4148	24	the	the	DT
cord-001835-0s7ok4uw	4148	25	literature	literature	NN
cord-001835-0s7ok4uw	4148	26	for	for	IN
cord-001835-0s7ok4uw	4148	27	computational	computational	JJ
cord-001835-0s7ok4uw	4148	28	Kemp	Kemp	NNP
cord-001835-0s7ok4uw	4148	29	-	-	HYPH
cord-001835-0s7ok4uw	4148	30	eliminase	eliminase	NNP
cord-001835-0s7ok4uw	4148	31	designs	design	NNS
cord-001835-0s7ok4uw	4148	32	involving	involve	VBG
cord-001835-0s7ok4uw	4148	33	multiple	multiple	JJ
cord-001835-0s7ok4uw	4148	34	mutations	mutation	NNS
cord-001835-0s7ok4uw	4148	35	.	.	.
cord-001835-0s7ok4uw	4149	1	Remarkably	remarkably	RB
cord-001835-0s7ok4uw	4149	2	,	,	,
cord-001835-0s7ok4uw	4149	3	the	the	DT
cord-001835-0s7ok4uw	4149	4	approach	approach	NN
cord-001835-0s7ok4uw	4149	5	was	be	VBD
cord-001835-0s7ok4uw	4149	6	unsuccessful	unsuccessful	JJ
cord-001835-0s7ok4uw	4149	7	when	when	WRB
cord-001835-0s7ok4uw	4149	8	performed	perform	VBN
cord-001835-0s7ok4uw	4149	9	on	on	IN
cord-001835-0s7ok4uw	4149	10	modern	modern	JJ
cord-001835-0s7ok4uw	4149	11	b	b	NN
cord-001835-0s7ok4uw	4149	12	-	-	HYPH
cord-001835-0s7ok4uw	4149	13	lactamases	lactamase	NNS
cord-001835-0s7ok4uw	4149	14	.	.	.
cord-001835-0s7ok4uw	4150	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4150	2	provide	provide	VBP
cord-001835-0s7ok4uw	4150	3	experimental	experimental	JJ
cord-001835-0s7ok4uw	4150	4	evidence	evidence	NN
cord-001835-0s7ok4uw	4150	5	that	that	IN
cord-001835-0s7ok4uw	4150	6	enhanced	enhance	VBD
cord-001835-0s7ok4uw	4150	7	conformational	conformational	JJ
cord-001835-0s7ok4uw	4150	8	flexibility	flexibility	NN
cord-001835-0s7ok4uw	4150	9	contributes	contribute	VBZ
cord-001835-0s7ok4uw	4150	10	to	to	IN
cord-001835-0s7ok4uw	4150	11	the	the	DT
cord-001835-0s7ok4uw	4150	12	success	success	NN
cord-001835-0s7ok4uw	4150	13	of	of	IN
cord-001835-0s7ok4uw	4150	14	the	the	DT
cord-001835-0s7ok4uw	4150	15	minimalist	minimalist	JJ
cord-001835-0s7ok4uw	4150	16	design	design	NN
cord-001835-0s7ok4uw	4150	17	in	in	IN
cord-001835-0s7ok4uw	4150	18	the	the	DT
cord-001835-0s7ok4uw	4150	19	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	4150	20	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	4150	21	.	.	.
cord-001835-0s7ok4uw	4151	1	This	this	DT
cord-001835-0s7ok4uw	4151	2	work	work	NN
cord-001835-0s7ok4uw	4151	3	has	have	VBZ
cord-001835-0s7ok4uw	4151	4	implications	implication	NNS
cord-001835-0s7ok4uw	4151	5	for	for	IN
cord-001835-0s7ok4uw	4151	6	the	the	DT
cord-001835-0s7ok4uw	4151	7	understanding	understanding	NN
cord-001835-0s7ok4uw	4151	8	of	of	IN
cord-001835-0s7ok4uw	4151	9	function	function	NN
cord-001835-0s7ok4uw	4151	10	emergence	emergence	NN
cord-001835-0s7ok4uw	4151	11	in	in	IN
cord-001835-0s7ok4uw	4151	12	protein	protein	NN
cord-001835-0s7ok4uw	4151	13	evolution	evolution	NN
cord-001835-0s7ok4uw	4151	14	and	and	CC
cord-001835-0s7ok4uw	4151	15	demonstrates	demonstrate	VBZ
cord-001835-0s7ok4uw	4151	16	the	the	DT
cord-001835-0s7ok4uw	4151	17	potential	potential	NN
cord-001835-0s7ok4uw	4151	18	of	of	IN
cord-001835-0s7ok4uw	4151	19	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	4151	20	protein	protein	NN
cord-001835-0s7ok4uw	4151	21	resurrection	resurrection	NN
cord-001835-0s7ok4uw	4151	22	in	in	IN
cord-001835-0s7ok4uw	4151	23	enzyme	enzyme	NN
cord-001835-0s7ok4uw	4151	24	engineering	engineering	NN
cord-001835-0s7ok4uw	4151	25	and	and	CC
cord-001835-0s7ok4uw	4151	26	design	design	NN
cord-001835-0s7ok4uw	4151	27	.	.	.
cord-001835-0s7ok4uw	4152	1	Exploring	explore	VBG
cord-001835-0s7ok4uw	4152	2	the	the	DT
cord-001835-0s7ok4uw	4152	3	Importance	importance	NN
cord-001835-0s7ok4uw	4152	4	of	of	IN
cord-001835-0s7ok4uw	4152	5	Dimerization	Dimerization	NNP
cord-001835-0s7ok4uw	4152	6	for	for	IN
cord-001835-0s7ok4uw	4152	7	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4152	8	Function	Function	NNP
cord-001835-0s7ok4uw	4152	9	through	through	IN
cord-001835-0s7ok4uw	4152	10	Engineered	Engineered	NNP
cord-001835-0s7ok4uw	4152	11	Domain	Domain	NNP
cord-001835-0s7ok4uw	4152	12	Fusions	Fusions	NNPS
cord-001835-0s7ok4uw	4152	13	Sierra	Sierra	NNP
cord-001835-0s7ok4uw	4152	14	Hansen	Hansen	NNP
cord-001835-0s7ok4uw	4152	15	1	1	CD
cord-001835-0s7ok4uw	4152	16	,	,	,
cord-001835-0s7ok4uw	4152	17	Jiusheng	Jiusheng	NNP
cord-001835-0s7ok4uw	4152	18	Lin	Lin	NNP
cord-001835-0s7ok4uw	4152	19	1	1	CD
cord-001835-0s7ok4uw	4152	20	,	,	,
cord-001835-0s7ok4uw	4152	21	Mark	Mark	NNP
cord-001835-0s7ok4uw	4152	22	Wilson	Wilson	NNP
cord-001835-0s7ok4uw	4152	23	1	1	CD
cord-001835-0s7ok4uw	4152	24	1	1	CD
cord-001835-0s7ok4uw	4152	25	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	4152	26	's	's	POS
cord-001835-0s7ok4uw	4152	27	Disease	Disease	NNP
cord-001835-0s7ok4uw	4152	28	is	be	VBZ
cord-001835-0s7ok4uw	4152	29	a	a	DT
cord-001835-0s7ok4uw	4152	30	progressive	progressive	JJ
cord-001835-0s7ok4uw	4152	31	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	4152	32	disease	disease	NN
cord-001835-0s7ok4uw	4152	33	that	that	WDT
cord-001835-0s7ok4uw	4152	34	affects	affect	VBZ
cord-001835-0s7ok4uw	4152	35	approximately	approximately	RB
cord-001835-0s7ok4uw	4152	36	6.3	6.3	CD
cord-001835-0s7ok4uw	4152	37	million	million	CD
cord-001835-0s7ok4uw	4152	38	people	people	NNS
cord-001835-0s7ok4uw	4152	39	worldwide	worldwide	RB
cord-001835-0s7ok4uw	4152	40	and	and	CC
cord-001835-0s7ok4uw	4152	41	is	be	VBZ
cord-001835-0s7ok4uw	4152	42	characterized	characterize	VBN
cord-001835-0s7ok4uw	4152	43	by	by	IN
cord-001835-0s7ok4uw	4152	44	the	the	DT
cord-001835-0s7ok4uw	4152	45	loss	loss	NN
cord-001835-0s7ok4uw	4152	46	of	of	IN
cord-001835-0s7ok4uw	4152	47	dopaminergic	dopaminergic	JJ
cord-001835-0s7ok4uw	4152	48	neurons	neuron	NNS
cord-001835-0s7ok4uw	4152	49	in	in	IN
cord-001835-0s7ok4uw	4152	50	the	the	DT
cord-001835-0s7ok4uw	4152	51	substantia	substantia	NNP
cord-001835-0s7ok4uw	4152	52	nigra	nigra	NNP
cord-001835-0s7ok4uw	4152	53	pars	pars	NNP
cord-001835-0s7ok4uw	4152	54	compacta	compacta	NN
cord-001835-0s7ok4uw	4152	55	.	.	.
cord-001835-0s7ok4uw	4153	1	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4153	2	(	(	-LRB-
cord-001835-0s7ok4uw	4153	3	PARK7	PARK7	NNP
cord-001835-0s7ok4uw	4153	4	)	)	-RRB-
cord-001835-0s7ok4uw	4153	5	is	be	VBZ
cord-001835-0s7ok4uw	4153	6	one	one	CD
cord-001835-0s7ok4uw	4153	7	of	of	IN
cord-001835-0s7ok4uw	4153	8	several	several	JJ
cord-001835-0s7ok4uw	4153	9	genes	gene	NNS
cord-001835-0s7ok4uw	4153	10	that	that	WDT
cord-001835-0s7ok4uw	4153	11	are	be	VBP
cord-001835-0s7ok4uw	4153	12	mutated	mutate	VBN
cord-001835-0s7ok4uw	4153	13	in	in	IN
cord-001835-0s7ok4uw	4153	14	rare	rare	JJ
cord-001835-0s7ok4uw	4153	15	forms	form	NNS
cord-001835-0s7ok4uw	4153	16	of	of	IN
cord-001835-0s7ok4uw	4153	17	familial	familial	JJ
cord-001835-0s7ok4uw	4153	18	parkinsonism	parkinsonism	NN
cord-001835-0s7ok4uw	4153	19	.	.	.
cord-001835-0s7ok4uw	4154	1	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4154	2	is	be	VBZ
cord-001835-0s7ok4uw	4154	3	a	a	DT
cord-001835-0s7ok4uw	4154	4	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	4154	5	cytoprotective	cytoprotective	JJ
cord-001835-0s7ok4uw	4154	6	protein	protein	NN
cord-001835-0s7ok4uw	4154	7	that	that	WDT
cord-001835-0s7ok4uw	4154	8	defends	defend	VBZ
cord-001835-0s7ok4uw	4154	9	against	against	IN
cord-001835-0s7ok4uw	4154	10	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	4154	11	stress	stress	NN
cord-001835-0s7ok4uw	4154	12	and	and	CC
cord-001835-0s7ok4uw	4154	13	preserves	preserve	VBZ
cord-001835-0s7ok4uw	4154	14	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	4154	15	function	function	NN
cord-001835-0s7ok4uw	4154	16	.	.	.
cord-001835-0s7ok4uw	4155	1	Dimerization	Dimerization	NNP
cord-001835-0s7ok4uw	4155	2	of	of	IN
cord-001835-0s7ok4uw	4155	3	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4155	4	is	be	VBZ
cord-001835-0s7ok4uw	4155	5	thought	think	VBN
cord-001835-0s7ok4uw	4155	6	to	to	TO
cord-001835-0s7ok4uw	4155	7	be	be	VB
cord-001835-0s7ok4uw	4155	8	essential	essential	JJ
cord-001835-0s7ok4uw	4155	9	for	for	IN
cord-001835-0s7ok4uw	4155	10	this	this	DT
cord-001835-0s7ok4uw	4155	11	function	function	NN
cord-001835-0s7ok4uw	4155	12	,	,	,
cord-001835-0s7ok4uw	4155	13	as	as	IN
cord-001835-0s7ok4uw	4155	14	some	some	DT
cord-001835-0s7ok4uw	4155	15	diseaseassociated	diseaseassociated	JJ
cord-001835-0s7ok4uw	4155	16	mutations	mutation	NNS
cord-001835-0s7ok4uw	4155	17	cause	cause	VBP
cord-001835-0s7ok4uw	4155	18	poor	poor	JJ
cord-001835-0s7ok4uw	4155	19	folding	folding	NN
cord-001835-0s7ok4uw	4155	20	and	and	CC
cord-001835-0s7ok4uw	4155	21	disrupt	disrupt	VB
cord-001835-0s7ok4uw	4155	22	the	the	DT
cord-001835-0s7ok4uw	4155	23	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4155	24	dimer	dimer	NN
cord-001835-0s7ok4uw	4155	25	.	.	.
cord-001835-0s7ok4uw	4156	1	However	however	RB
cord-001835-0s7ok4uw	4156	2	,	,	,
cord-001835-0s7ok4uw	4156	3	recent	recent	JJ
cord-001835-0s7ok4uw	4156	4	reports	report	NNS
cord-001835-0s7ok4uw	4156	5	suggest	suggest	VBP
cord-001835-0s7ok4uw	4156	6	that	that	IN
cord-001835-0s7ok4uw	4156	7	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4156	8	may	may	MD
cord-001835-0s7ok4uw	4156	9	be	be	VB
cord-001835-0s7ok4uw	4156	10	functional	functional	JJ
cord-001835-0s7ok4uw	4156	11	as	as	IN
cord-001835-0s7ok4uw	4156	12	a	a	DT
cord-001835-0s7ok4uw	4156	13	monomer	monomer	NN
cord-001835-0s7ok4uw	4156	14	.	.	.
cord-001835-0s7ok4uw	4157	1	To	to	TO
cord-001835-0s7ok4uw	4157	2	test	test	VB
cord-001835-0s7ok4uw	4157	3	this	this	DT
cord-001835-0s7ok4uw	4157	4	,	,	,
cord-001835-0s7ok4uw	4157	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4157	6	have	have	VBP
cord-001835-0s7ok4uw	4157	7	engineered	engineer	VBN
cord-001835-0s7ok4uw	4157	8	a	a	DT
cord-001835-0s7ok4uw	4157	9	non	non	JJ
cord-001835-0s7ok4uw	4157	10	-	-	JJ
cord-001835-0s7ok4uw	4157	11	dissociable	dissociable	JJ
cord-001835-0s7ok4uw	4157	12	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4157	13	dimer	dimer	NN
cord-001835-0s7ok4uw	4157	14	that	that	WDT
cord-001835-0s7ok4uw	4157	15	is	be	VBZ
cord-001835-0s7ok4uw	4157	16	a	a	DT
cord-001835-0s7ok4uw	4157	17	fusion	fusion	NN
cord-001835-0s7ok4uw	4157	18	of	of	IN
cord-001835-0s7ok4uw	4157	19	two	two	CD
cord-001835-0s7ok4uw	4157	20	human	human	JJ
cord-001835-0s7ok4uw	4157	21	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4157	22	domains	domain	NNS
cord-001835-0s7ok4uw	4157	23	.	.	.
cord-001835-0s7ok4uw	4158	1	This	this	DT
cord-001835-0s7ok4uw	4158	2	construct	construct	NN
cord-001835-0s7ok4uw	4158	3	can	can	MD
cord-001835-0s7ok4uw	4158	4	not	not	RB
cord-001835-0s7ok4uw	4158	5	dissociate	dissociate	VB
cord-001835-0s7ok4uw	4158	6	into	into	IN
cord-001835-0s7ok4uw	4158	7	monomers	monomer	NNS
cord-001835-0s7ok4uw	4158	8	and	and	CC
cord-001835-0s7ok4uw	4158	9	thus	thus	RB
cord-001835-0s7ok4uw	4158	10	will	will	MD
cord-001835-0s7ok4uw	4158	11	provide	provide	VB
cord-001835-0s7ok4uw	4158	12	a	a	DT
cord-001835-0s7ok4uw	4158	13	stringent	stringent	JJ
cord-001835-0s7ok4uw	4158	14	test	test	NN
cord-001835-0s7ok4uw	4158	15	of	of	IN
cord-001835-0s7ok4uw	4158	16	the	the	DT
cord-001835-0s7ok4uw	4158	17	importance	importance	NN
cord-001835-0s7ok4uw	4158	18	of	of	IN
cord-001835-0s7ok4uw	4158	19	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	4158	20	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4158	21	.	.	.
cord-001835-0s7ok4uw	4159	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4159	2	engineered	engineer	VBN
cord-001835-0s7ok4uw	4159	3	construct	construct	NN
cord-001835-0s7ok4uw	4159	4	is	be	VBZ
cord-001835-0s7ok4uw	4159	5	modeled	model	VBN
cord-001835-0s7ok4uw	4159	6	on	on	IN
cord-001835-0s7ok4uw	4159	7	plant	plant	NN
cord-001835-0s7ok4uw	4159	8	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4159	9	homologs	homolog	NNS
cord-001835-0s7ok4uw	4159	10	,	,	,
cord-001835-0s7ok4uw	4159	11	which	which	WDT
cord-001835-0s7ok4uw	4159	12	feature	feature	VBP
cord-001835-0s7ok4uw	4159	13	naturally	naturally	RB
cord-001835-0s7ok4uw	4159	14	occurring	occur	VBG
cord-001835-0s7ok4uw	4159	15	duplicate	duplicate	JJ
cord-001835-0s7ok4uw	4159	16	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4159	17	domains	domain	NNS
cord-001835-0s7ok4uw	4159	18	separated	separate	VBN
cord-001835-0s7ok4uw	4159	19	by	by	IN
cord-001835-0s7ok4uw	4159	20	a	a	DT
cord-001835-0s7ok4uw	4159	21	small	small	JJ
cord-001835-0s7ok4uw	4159	22	(	(	-LRB-
cord-001835-0s7ok4uw	4159	23	19	19	CD
cord-001835-0s7ok4uw	4159	24	amino	amino	NN
cord-001835-0s7ok4uw	4159	25	acid	acid	NN
cord-001835-0s7ok4uw	4159	26	)	)	-RRB-
cord-001835-0s7ok4uw	4159	27	linker	linker	NN
cord-001835-0s7ok4uw	4159	28	region	region	NN
cord-001835-0s7ok4uw	4159	29	.	.	.
cord-001835-0s7ok4uw	4160	1	Using	use	VBG
cord-001835-0s7ok4uw	4160	2	X	x	NN
cord-001835-0s7ok4uw	4160	3	-	-	NN
cord-001835-0s7ok4uw	4160	4	ray	ray	NN
cord-001835-0s7ok4uw	4160	5	crystallography	crystallography	NN
cord-001835-0s7ok4uw	4160	6	,	,	,
cord-001835-0s7ok4uw	4160	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	4160	8	confirmed	confirm	VBD
cord-001835-0s7ok4uw	4160	9	that	that	IN
cord-001835-0s7ok4uw	4160	10	this	this	DT
cord-001835-0s7ok4uw	4160	11	engineered	engineer	VBN
cord-001835-0s7ok4uw	4160	12	non	non	JJ
cord-001835-0s7ok4uw	4160	13	-	-	JJ
cord-001835-0s7ok4uw	4160	14	dissociable	dissociable	JJ
cord-001835-0s7ok4uw	4160	15	human	human	JJ
cord-001835-0s7ok4uw	4160	16	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4160	17	dimer	dimer	NN
cord-001835-0s7ok4uw	4160	18	has	have	VBZ
cord-001835-0s7ok4uw	4160	19	identical	identical	JJ
cord-001835-0s7ok4uw	4160	20	structure	structure	NN
cord-001835-0s7ok4uw	4160	21	to	to	IN
cord-001835-0s7ok4uw	4160	22	the	the	DT
cord-001835-0s7ok4uw	4160	23	naturally	naturally	RB
cord-001835-0s7ok4uw	4160	24	occurring	occur	VBG
cord-001835-0s7ok4uw	4160	25	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	4160	26	protein	protein	NN
cord-001835-0s7ok4uw	4160	27	.	.	.
cord-001835-0s7ok4uw	4161	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4161	2	have	have	VBP
cord-001835-0s7ok4uw	4161	3	investigated	investigate	VBN
cord-001835-0s7ok4uw	4161	4	the	the	DT
cord-001835-0s7ok4uw	4161	5	influence	influence	NN
cord-001835-0s7ok4uw	4161	6	of	of	IN
cord-001835-0s7ok4uw	4161	7	enforced	enforce	VBN
cord-001835-0s7ok4uw	4161	8	dimerization	dimerization	NN
cord-001835-0s7ok4uw	4161	9	of	of	IN
cord-001835-0s7ok4uw	4161	10	the	the	DT
cord-001835-0s7ok4uw	4161	11	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	4161	12	effects	effect	NNS
cord-001835-0s7ok4uw	4161	13	of	of	IN
cord-001835-0s7ok4uw	4161	14	the	the	DT
cord-001835-0s7ok4uw	4161	15	parkinsonian	parkinsonian	NNP
cord-001835-0s7ok4uw	4161	16	L166P	L166P	NNP
cord-001835-0s7ok4uw	4161	17	and	and	CC
cord-001835-0s7ok4uw	4161	18	L10P	L10P	NNP
cord-001835-0s7ok4uw	4161	19	mutations	mutation	NNS
cord-001835-0s7ok4uw	4161	20	.	.	.
cord-001835-0s7ok4uw	4162	1	CD	CD	NNP
cord-001835-0s7ok4uw	4162	2	spectroscopic	spectroscopic	JJ
cord-001835-0s7ok4uw	4162	3	analysis	analysis	NN
cord-001835-0s7ok4uw	4162	4	reveals	reveal	VBZ
cord-001835-0s7ok4uw	4162	5	that	that	IN
cord-001835-0s7ok4uw	4162	6	single	single	JJ
cord-001835-0s7ok4uw	4162	7	and	and	CC
cord-001835-0s7ok4uw	4162	8	double	double	JJ
cord-001835-0s7ok4uw	4162	9	L166P	l166p	NN
cord-001835-0s7ok4uw	4162	10	mutations	mutation	NNS
cord-001835-0s7ok4uw	4162	11	in	in	IN
cord-001835-0s7ok4uw	4162	12	the	the	DT
cord-001835-0s7ok4uw	4162	13	non	non	JJ
cord-001835-0s7ok4uw	4162	14	-	-	JJ
cord-001835-0s7ok4uw	4162	15	dissociable	dissociable	JJ
cord-001835-0s7ok4uw	4162	16	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4162	17	dimer	dimer	NNP
cord-001835-0s7ok4uw	4162	18	maintain	maintain	VBP
cord-001835-0s7ok4uw	4162	19	a	a	DT
cord-001835-0s7ok4uw	4162	20	higher	high	JJR
cord-001835-0s7ok4uw	4162	21	degree	degree	NN
cord-001835-0s7ok4uw	4162	22	of	of	IN
cord-001835-0s7ok4uw	4162	23	structure	structure	NN
cord-001835-0s7ok4uw	4162	24	than	than	IN
cord-001835-0s7ok4uw	4162	25	L166P	L166P	NNP
cord-001835-0s7ok4uw	4162	26	mutations	mutation	NNS
cord-001835-0s7ok4uw	4162	27	in	in	IN
cord-001835-0s7ok4uw	4162	28	the	the	DT
cord-001835-0s7ok4uw	4162	29	native	native	JJ
cord-001835-0s7ok4uw	4162	30	protein	protein	NN
cord-001835-0s7ok4uw	4162	31	.	.	.
cord-001835-0s7ok4uw	4163	1	Additional	additional	JJ
cord-001835-0s7ok4uw	4163	2	characterization	characterization	NN
cord-001835-0s7ok4uw	4163	3	of	of	IN
cord-001835-0s7ok4uw	4163	4	the	the	DT
cord-001835-0s7ok4uw	4163	5	protective	protective	JJ
cord-001835-0s7ok4uw	4163	6	capacity	capacity	NN
cord-001835-0s7ok4uw	4163	7	and	and	CC
cord-001835-0s7ok4uw	4163	8	subcellular	subcellular	JJ
cord-001835-0s7ok4uw	4163	9	trafficking	trafficking	NN
cord-001835-0s7ok4uw	4163	10	of	of	IN
cord-001835-0s7ok4uw	4163	11	this	this	DT
cord-001835-0s7ok4uw	4163	12	non	non	JJ
cord-001835-0s7ok4uw	4163	13	-	-	JJ
cord-001835-0s7ok4uw	4163	14	dissociable	dissociable	JJ
cord-001835-0s7ok4uw	4163	15	DJ-1	DJ-1	NNP
cord-001835-0s7ok4uw	4163	16	dimer	dimer	NN
cord-001835-0s7ok4uw	4163	17	is	be	VBZ
cord-001835-0s7ok4uw	4163	18	underway	underway	JJ
cord-001835-0s7ok4uw	4163	19	.	.	.
cord-001835-0s7ok4uw	4164	1	The	the	DT
cord-001835-0s7ok4uw	4164	2	purification	purification	NN
cord-001835-0s7ok4uw	4164	3	,	,	,
cord-001835-0s7ok4uw	4164	4	crystallization	crystallization	NN
cord-001835-0s7ok4uw	4164	5	and	and	CC
cord-001835-0s7ok4uw	4164	6	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	4164	7	characterization	characterization	NN
cord-001835-0s7ok4uw	4164	8	of	of	IN
cord-001835-0s7ok4uw	4164	9	SdrE	SdrE	NNP
cord-001835-0s7ok4uw	4164	10	from	from	IN
cord-001835-0s7ok4uw	4164	11	S.	S.	NNP
cord-001835-0s7ok4uw	4164	12	aureus	aureus	NN
cord-001835-0s7ok4uw	4165	1	The	the	DT
cord-001835-0s7ok4uw	4165	2	purification	purification	NN
cord-001835-0s7ok4uw	4165	3	,	,	,
cord-001835-0s7ok4uw	4165	4	crystallization	crystallization	NN
cord-001835-0s7ok4uw	4165	5	and	and	CC
cord-001835-0s7ok4uw	4165	6	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	4165	7	characterization	characterization	NN
cord-001835-0s7ok4uw	4165	8	of	of	IN
cord-001835-0s7ok4uw	4165	9	SdrE	SdrE	NNP
cord-001835-0s7ok4uw	4165	10	from	from	IN
cord-001835-0s7ok4uw	4165	11	S.	S.	NNP
cord-001835-0s7ok4uw	4165	12	aureus	aureus	NN
cord-001835-0s7ok4uw	4165	13	Staphylococcus	Staphylococcus	NNP
cord-001835-0s7ok4uw	4165	14	aureus	aureus	NN
cord-001835-0s7ok4uw	4165	15	(	(	-LRB-
cord-001835-0s7ok4uw	4165	16	S.aureus	s.aureu	NNS
cord-001835-0s7ok4uw	4165	17	)	)	-RRB-
cord-001835-0s7ok4uw	4165	18	is	be	VBZ
cord-001835-0s7ok4uw	4165	19	an	an	DT
cord-001835-0s7ok4uw	4165	20	important	important	JJ
cord-001835-0s7ok4uw	4165	21	human	human	JJ
cord-001835-0s7ok4uw	4165	22	opportunistic	opportunistic	JJ
cord-001835-0s7ok4uw	4165	23	pathogen	pathogen	NN
cord-001835-0s7ok4uw	4165	24	which	which	WDT
cord-001835-0s7ok4uw	4165	25	colonizes	colonize	VBZ
cord-001835-0s7ok4uw	4165	26	about	about	IN
cord-001835-0s7ok4uw	4165	27	20	20	CD
cord-001835-0s7ok4uw	4165	28	%	%	NN
cord-001835-0s7ok4uw	4165	29	of	of	IN
cord-001835-0s7ok4uw	4165	30	the	the	DT
cord-001835-0s7ok4uw	4165	31	human	human	JJ
cord-001835-0s7ok4uw	4165	32	population	population	NN
cord-001835-0s7ok4uw	4165	33	persistently	persistently	RB
cord-001835-0s7ok4uw	4165	34	[	[	-LRB-
cord-001835-0s7ok4uw	4165	35	1	1	CD
cord-001835-0s7ok4uw	4165	36	]	]	-RRB-
cord-001835-0s7ok4uw	4165	37	.	.	.
cord-001835-0s7ok4uw	4166	1	Surface	surface	NN
cord-001835-0s7ok4uw	4166	2	proteins	protein	NNS
cord-001835-0s7ok4uw	4166	3	of	of	IN
cord-001835-0s7ok4uw	4166	4	S.aureus	s.aureu	NNS
cord-001835-0s7ok4uw	4166	5	can	can	MD
cord-001835-0s7ok4uw	4166	6	excretion	excretion	VB
cord-001835-0s7ok4uw	4166	7	a	a	DT
cord-001835-0s7ok4uw	4166	8	kind	kind	NN
cord-001835-0s7ok4uw	4166	9	of	of	IN
cord-001835-0s7ok4uw	4166	10	sortase	sortase	NN
cord-001835-0s7ok4uw	4166	11	,	,	,
cord-001835-0s7ok4uw	4166	12	which	which	WDT
cord-001835-0s7ok4uw	4166	13	represents	represent	VBZ
cord-001835-0s7ok4uw	4166	14	a	a	DT
cord-001835-0s7ok4uw	4166	15	surface	surface	NN
cord-001835-0s7ok4uw	4166	16	organelle	organelle	NN
cord-001835-0s7ok4uw	4166	17	responsible	responsible	JJ
cord-001835-0s7ok4uw	4166	18	during	during	IN
cord-001835-0s7ok4uw	4166	19	the	the	DT
cord-001835-0s7ok4uw	4166	20	pathogenesis	pathogenesis	NN
cord-001835-0s7ok4uw	4166	21	of	of	IN
cord-001835-0s7ok4uw	4166	22	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	4166	23	infection	infection	NN
cord-001835-0s7ok4uw	4166	24	the	the	DT
cord-001835-0s7ok4uw	4166	25	host	host	NN
cord-001835-0s7ok4uw	4166	26	circulation	circulation	NN
cord-001835-0s7ok4uw	4166	27	[	[	-LRB-
cord-001835-0s7ok4uw	4166	28	2	2	CD
cord-001835-0s7ok4uw	4166	29	]	]	-RRB-
cord-001835-0s7ok4uw	4166	30	.	.	.
cord-001835-0s7ok4uw	4167	1	Sdr	Sdr	NNP
cord-001835-0s7ok4uw	4167	2	proteins	protein	NNS
cord-001835-0s7ok4uw	4167	3	were	be	VBD
cord-001835-0s7ok4uw	4167	4	a	a	DT
cord-001835-0s7ok4uw	4167	5	component	component	NN
cord-001835-0s7ok4uw	4167	6	of	of	IN
cord-001835-0s7ok4uw	4167	7	cell	cell	NN
cord-001835-0s7ok4uw	4167	8	wall	wall	NN
cord-001835-0s7ok4uw	4167	9	anchored	anchor	VBD
cord-001835-0s7ok4uw	4167	10	family	family	NN
cord-001835-0s7ok4uw	4167	11	proteins	protein	NNS
cord-001835-0s7ok4uw	4167	12	,	,	,
cord-001835-0s7ok4uw	4167	13	including	include	VBG
cord-001835-0s7ok4uw	4167	14	SdrC	SdrC	NNP
cord-001835-0s7ok4uw	4167	15	,	,	,
cord-001835-0s7ok4uw	4167	16	SdrD	SdrD	NNP
cord-001835-0s7ok4uw	4167	17	and	and	CC
cord-001835-0s7ok4uw	4167	18	SdrE	SdrE	NNP
cord-001835-0s7ok4uw	4167	19	[	[	-LRB-
cord-001835-0s7ok4uw	4167	20	3	3	CD
cord-001835-0s7ok4uw	4167	21	]	]	-RRB-
cord-001835-0s7ok4uw	4167	22	.	.	.
cord-001835-0s7ok4uw	4168	1	SdrE	SdrE	NNP
cord-001835-0s7ok4uw	4168	2	could	could	MD
cord-001835-0s7ok4uw	4168	3	combine	combine	VB
cord-001835-0s7ok4uw	4168	4	with	with	IN
cord-001835-0s7ok4uw	4168	5	the	the	DT
cord-001835-0s7ok4uw	4168	6	complement	complement	JJ
cord-001835-0s7ok4uw	4168	7	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	4168	8	protein	protein	NN
cord-001835-0s7ok4uw	4168	9	factor	factor	NN
cord-001835-0s7ok4uw	4168	10	H	H	NNP
cord-001835-0s7ok4uw	4168	11	to	to	TO
cord-001835-0s7ok4uw	4168	12	escape	escape	VB
cord-001835-0s7ok4uw	4168	13	the	the	DT
cord-001835-0s7ok4uw	4168	14	alternative	alternative	JJ
cord-001835-0s7ok4uw	4168	15	pathway	pathway	NN
cord-001835-0s7ok4uw	4168	16	of	of	IN
cord-001835-0s7ok4uw	4168	17	complement	complement	NN
cord-001835-0s7ok4uw	4168	18	[	[	-LRB-
cord-001835-0s7ok4uw	4168	19	4	4	CD
cord-001835-0s7ok4uw	4168	20	]	]	-RRB-
cord-001835-0s7ok4uw	4168	21	.	.	.
cord-001835-0s7ok4uw	4169	1	To	to	TO
cord-001835-0s7ok4uw	4169	2	further	further	RB
cord-001835-0s7ok4uw	4169	3	investigate	investigate	VB
cord-001835-0s7ok4uw	4169	4	the	the	DT
cord-001835-0s7ok4uw	4169	5	functions	function	NNS
cord-001835-0s7ok4uw	4169	6	of	of	IN
cord-001835-0s7ok4uw	4169	7	SdrE	SdrE	NNP
cord-001835-0s7ok4uw	4169	8	,	,	,
cord-001835-0s7ok4uw	4169	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	4169	10	have	have	VBP
cord-001835-0s7ok4uw	4169	11	expressed	express	VBN
cord-001835-0s7ok4uw	4169	12	and	and	CC
cord-001835-0s7ok4uw	4169	13	purified	purify	VBN
cord-001835-0s7ok4uw	4169	14	the	the	DT
cord-001835-0s7ok4uw	4169	15	adhesive	adhesive	JJ
cord-001835-0s7ok4uw	4169	16	domain	domain	NN
cord-001835-0s7ok4uw	4169	17	(	(	-LRB-
cord-001835-0s7ok4uw	4169	18	residues	residue	NNS
cord-001835-0s7ok4uw	4169	19	141-'06:15	141-'06:15	CD
cord-001835-0s7ok4uw	4169	20	)	)	-RRB-
cord-001835-0s7ok4uw	4169	21	,	,	,
cord-001835-0s7ok4uw	4169	22	and	and	CC
cord-001835-0s7ok4uw	4169	23	crystallized	crystallize	VBD
cord-001835-0s7ok4uw	4169	24	the	the	DT
cord-001835-0s7ok4uw	4169	25	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	4169	26	protein	protein	NN
cord-001835-0s7ok4uw	4169	27	.	.	.
cord-001835-0s7ok4uw	4170	1	In	in	IN
cord-001835-0s7ok4uw	4170	2	addition	addition	NN
cord-001835-0s7ok4uw	4170	3	,	,	,
cord-001835-0s7ok4uw	4170	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	4170	5	also	also	RB
cord-001835-0s7ok4uw	4170	6	constructed	construct	VBD
cord-001835-0s7ok4uw	4170	7	the	the	DT
cord-001835-0s7ok4uw	4170	8	mutant	mutant	JJ
cord-001835-0s7ok4uw	4170	9	S.aureus	s.aureu	NNS
cord-001835-0s7ok4uw	4170	10	,	,	,
cord-001835-0s7ok4uw	4170	11	and	and	CC
cord-001835-0s7ok4uw	4170	12	the	the	DT
cord-001835-0s7ok4uw	4170	13	cell	cell	NN
cord-001835-0s7ok4uw	4170	14	experiments	experiment	NNS
cord-001835-0s7ok4uw	4170	15	confirmed	confirm	VBD
cord-001835-0s7ok4uw	4170	16	that	that	IN
cord-001835-0s7ok4uw	4170	17	SdrE	SdrE	NNP
cord-001835-0s7ok4uw	4170	18	gene	gene	NN
cord-001835-0s7ok4uw	4170	19	participate	participate	VB
cord-001835-0s7ok4uw	4170	20	in	in	IN
cord-001835-0s7ok4uw	4170	21	the	the	DT
cord-001835-0s7ok4uw	4170	22	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	4170	23	invasion	invasion	NN
cord-001835-0s7ok4uw	4170	24	.	.	.
cord-001835-0s7ok4uw	4171	1	Bacterial	bacterial	JJ
cord-001835-0s7ok4uw	4171	2	Microcompartments	Microcompartments	NNP
cord-001835-0s7ok4uw	4171	3	(	(	-LRB-
cord-001835-0s7ok4uw	4171	4	BMCs	BMCs	NNP
cord-001835-0s7ok4uw	4171	5	)	)	-RRB-
cord-001835-0s7ok4uw	4171	6	are	be	VBP
cord-001835-0s7ok4uw	4171	7	proteinaceous	proteinaceous	JJ
cord-001835-0s7ok4uw	4171	8	organelles	organelle	NNS
cord-001835-0s7ok4uw	4171	9	that	that	WDT
cord-001835-0s7ok4uw	4171	10	sequester	sequester	VBP
cord-001835-0s7ok4uw	4171	11	key	key	JJ
cord-001835-0s7ok4uw	4171	12	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	4171	13	reactions	reaction	NNS
cord-001835-0s7ok4uw	4171	14	to	to	TO
cord-001835-0s7ok4uw	4171	15	increase	increase	VB
cord-001835-0s7ok4uw	4171	16	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	4171	17	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4171	18	or	or	CC
cord-001835-0s7ok4uw	4171	19	to	to	TO
cord-001835-0s7ok4uw	4171	20	prevent	prevent	VB
cord-001835-0s7ok4uw	4171	21	the	the	DT
cord-001835-0s7ok4uw	4171	22	loss	loss	NN
cord-001835-0s7ok4uw	4171	23	of	of	IN
cord-001835-0s7ok4uw	4171	24	volatile	volatile	JJ
cord-001835-0s7ok4uw	4171	25	or	or	CC
cord-001835-0s7ok4uw	4171	26	toxic	toxic	JJ
cord-001835-0s7ok4uw	4171	27	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	4171	28	.	.	.
cord-001835-0s7ok4uw	4172	1	There	there	EX
cord-001835-0s7ok4uw	4172	2	is	be	VBZ
cord-001835-0s7ok4uw	4172	3	an	an	DT
cord-001835-0s7ok4uw	4172	4	increasing	increase	VBG
cord-001835-0s7ok4uw	4172	5	desire	desire	NN
cord-001835-0s7ok4uw	4172	6	to	to	TO
cord-001835-0s7ok4uw	4172	7	engineer	engineer	VB
cord-001835-0s7ok4uw	4172	8	BMCs	bmc	NNS
cord-001835-0s7ok4uw	4172	9	for	for	IN
cord-001835-0s7ok4uw	4172	10	non	non	JJ
cord-001835-0s7ok4uw	4172	11	-	-	JJ
cord-001835-0s7ok4uw	4172	12	native	native	JJ
cord-001835-0s7ok4uw	4172	13	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	4172	14	processes	process	NNS
cord-001835-0s7ok4uw	4172	15	.	.	.
cord-001835-0s7ok4uw	4173	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4173	2	is	be	VBZ
cord-001835-0s7ok4uw	4173	3	thought	think	VBN
cord-001835-0s7ok4uw	4173	4	this	this	DT
cord-001835-0s7ok4uw	4173	5	will	will	MD
cord-001835-0s7ok4uw	4173	6	increase	increase	VB
cord-001835-0s7ok4uw	4173	7	multi	multi	JJ
cord-001835-0s7ok4uw	4173	8	-	-	JJ
cord-001835-0s7ok4uw	4173	9	enzyme	enzyme	JJ
cord-001835-0s7ok4uw	4173	10	pathway	pathway	NN
cord-001835-0s7ok4uw	4173	11	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4173	12	and	and	CC
cord-001835-0s7ok4uw	4173	13	allow	allow	VB
cord-001835-0s7ok4uw	4173	14	the	the	DT
cord-001835-0s7ok4uw	4173	15	expression	expression	NN
cord-001835-0s7ok4uw	4173	16	pathways	pathway	NNS
cord-001835-0s7ok4uw	4173	17	that	that	WDT
cord-001835-0s7ok4uw	4173	18	may	may	MD
cord-001835-0s7ok4uw	4173	19	produce	produce	VB
cord-001835-0s7ok4uw	4173	20	toxic	toxic	JJ
cord-001835-0s7ok4uw	4173	21	or	or	CC
cord-001835-0s7ok4uw	4173	22	volatile	volatile	JJ
cord-001835-0s7ok4uw	4173	23	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	4173	24	in	in	IN
cord-001835-0s7ok4uw	4173	25	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	4173	26	.	.	.
cord-001835-0s7ok4uw	4174	1	The	the	DT
cord-001835-0s7ok4uw	4174	2	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4174	3	of	of	IN
cord-001835-0s7ok4uw	4174	4	small	small	JJ
cord-001835-0s7ok4uw	4174	5	molecule	molecule	NN
cord-001835-0s7ok4uw	4174	6	transport	transport	NN
cord-001835-0s7ok4uw	4174	7	and	and	CC
cord-001835-0s7ok4uw	4174	8	retention	retention	NN
cord-001835-0s7ok4uw	4174	9	of	of	IN
cord-001835-0s7ok4uw	4174	10	toxic	toxic	JJ
cord-001835-0s7ok4uw	4174	11	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	4174	12	by	by	IN
cord-001835-0s7ok4uw	4174	13	BMCs	bmc	NNS
cord-001835-0s7ok4uw	4174	14	remain	remain	VBP
cord-001835-0s7ok4uw	4174	15	poorly	poorly	RB
cord-001835-0s7ok4uw	4174	16	understood	understand	VBN
cord-001835-0s7ok4uw	4174	17	.	.	.
cord-001835-0s7ok4uw	4175	1	Better	well	JJR
cord-001835-0s7ok4uw	4175	2	understanding	understanding	NN
cord-001835-0s7ok4uw	4175	3	of	of	IN
cord-001835-0s7ok4uw	4175	4	the	the	DT
cord-001835-0s7ok4uw	4175	5	BMCs	bmc	NNS
cord-001835-0s7ok4uw	4175	6	pores	pore	NNS
cord-001835-0s7ok4uw	4175	7	critical	critical	JJ
cord-001835-0s7ok4uw	4175	8	to	to	TO
cord-001835-0s7ok4uw	4175	9	engineer	engineer	VB
cord-001835-0s7ok4uw	4175	10	BMCs	bmc	NNS
cord-001835-0s7ok4uw	4175	11	for	for	IN
cord-001835-0s7ok4uw	4175	12	these	these	DT
cord-001835-0s7ok4uw	4175	13	non	non	JJ
cord-001835-0s7ok4uw	4175	14	-	-	JJ
cord-001835-0s7ok4uw	4175	15	native	native	JJ
cord-001835-0s7ok4uw	4175	16	pathways	pathway	NNS
cord-001835-0s7ok4uw	4175	17	.	.	.
cord-001835-0s7ok4uw	4176	1	In	in	IN
cord-001835-0s7ok4uw	4176	2	order	order	NN
cord-001835-0s7ok4uw	4176	3	to	to	TO
cord-001835-0s7ok4uw	4176	4	better	better	RB
cord-001835-0s7ok4uw	4176	5	understand	understand	VB
cord-001835-0s7ok4uw	4176	6	the	the	DT
cord-001835-0s7ok4uw	4176	7	BMC	BMC	NNP
cord-001835-0s7ok4uw	4176	8	pore	pore	NN
cord-001835-0s7ok4uw	4176	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	4176	10	have	have	VBP
cord-001835-0s7ok4uw	4176	11	undertaken	undertake	VBN
cord-001835-0s7ok4uw	4176	12	structure	structure	NN
cord-001835-0s7ok4uw	4176	13	-	-	HYPH
cord-001835-0s7ok4uw	4176	14	guided	guide	VBN
cord-001835-0s7ok4uw	4176	15	modifications	modification	NNS
cord-001835-0s7ok4uw	4176	16	of	of	IN
cord-001835-0s7ok4uw	4176	17	the	the	DT
cord-001835-0s7ok4uw	4176	18	the	the	DT
cord-001835-0s7ok4uw	4176	19	hexameric	hexameric	JJ
cord-001835-0s7ok4uw	4176	20	PduA	PduA	NNP
cord-001835-0s7ok4uw	4176	21	shell	shell	NN
cord-001835-0s7ok4uw	4176	22	protein	protein	NN
cord-001835-0s7ok4uw	4176	23	of	of	IN
cord-001835-0s7ok4uw	4176	24	the	the	DT
cord-001835-0s7ok4uw	4176	25	1,2-propanediol	1,2-propanediol	CD
cord-001835-0s7ok4uw	4176	26	utilization	utilization	NN
cord-001835-0s7ok4uw	4176	27	microcompartment	microcompartment	NN
cord-001835-0s7ok4uw	4176	28	(	(	-LRB-
cord-001835-0s7ok4uw	4176	29	Pdu	Pdu	NNP
cord-001835-0s7ok4uw	4176	30	MCP	MCP	NNP
cord-001835-0s7ok4uw	4176	31	)	)	-RRB-
cord-001835-0s7ok4uw	4176	32	.	.	.
cord-001835-0s7ok4uw	4177	1	These	these	DT
cord-001835-0s7ok4uw	4177	2	modifications	modification	NNS
cord-001835-0s7ok4uw	4177	3	include	include	VBP
cord-001835-0s7ok4uw	4177	4	pore	pore	NN
cord-001835-0s7ok4uw	4177	5	mutations	mutation	NNS
cord-001835-0s7ok4uw	4177	6	in	in	IN
cord-001835-0s7ok4uw	4177	7	an	an	DT
cord-001835-0s7ok4uw	4177	8	attempt	attempt	NN
cord-001835-0s7ok4uw	4177	9	to	to	TO
cord-001835-0s7ok4uw	4177	10	alter	alter	VB
cord-001835-0s7ok4uw	4177	11	substrate	substrate	NN
cord-001835-0s7ok4uw	4177	12	specificity	specificity	NN
cord-001835-0s7ok4uw	4177	13	and	and	CC
cord-001835-0s7ok4uw	4177	14	permutations	permutation	NNS
cord-001835-0s7ok4uw	4177	15	of	of	IN
cord-001835-0s7ok4uw	4177	16	PduA	PduA	NNP
cord-001835-0s7ok4uw	4177	17	to	to	TO
cord-001835-0s7ok4uw	4177	18	allow	allow	VB
cord-001835-0s7ok4uw	4177	19	more	more	RBR
cord-001835-0s7ok4uw	4177	20	drastic	drastic	JJ
cord-001835-0s7ok4uw	4177	21	alterations	alteration	NNS
cord-001835-0s7ok4uw	4177	22	to	to	IN
cord-001835-0s7ok4uw	4177	23	the	the	DT
cord-001835-0s7ok4uw	4177	24	structure	structure	NN
cord-001835-0s7ok4uw	4177	25	of	of	IN
cord-001835-0s7ok4uw	4177	26	the	the	DT
cord-001835-0s7ok4uw	4177	27	protein	protein	NN
cord-001835-0s7ok4uw	4177	28	.	.	.
cord-001835-0s7ok4uw	4178	1	Crystal	crystal	NN
cord-001835-0s7ok4uw	4178	2	structures	structure	NNS
cord-001835-0s7ok4uw	4178	3	of	of	IN
cord-001835-0s7ok4uw	4178	4	PduA	PduA	NNP
cord-001835-0s7ok4uw	4178	5	pore	pore	NN
cord-001835-0s7ok4uw	4178	6	mutants	mutant	NNS
cord-001835-0s7ok4uw	4178	7	,	,	,
cord-001835-0s7ok4uw	4178	8	solved	solve	VBN
cord-001835-0s7ok4uw	4178	9	to	to	IN
cord-001835-0s7ok4uw	4178	10	atomic	atomic	JJ
cord-001835-0s7ok4uw	4178	11	resolution	resolution	NN
cord-001835-0s7ok4uw	4178	12	(	(	-LRB-
cord-001835-0s7ok4uw	4178	13	2	2	CD
cord-001835-0s7ok4uw	4178	14	-	-	HYPH
cord-001835-0s7ok4uw	4178	15	3.3Å	3.3å	NN
cord-001835-0s7ok4uw	4178	16	)	)	-RRB-
cord-001835-0s7ok4uw	4178	17	provide	provide	VBP
cord-001835-0s7ok4uw	4178	18	evidence	evidence	NN
cord-001835-0s7ok4uw	4178	19	of	of	IN
cord-001835-0s7ok4uw	4178	20	the	the	DT
cord-001835-0s7ok4uw	4178	21	pore	pore	NN
cord-001835-0s7ok4uw	4178	22	residues	residue	NNS
cord-001835-0s7ok4uw	4178	23	that	that	WDT
cord-001835-0s7ok4uw	4178	24	confer	confer	VBP
cord-001835-0s7ok4uw	4178	25	specificity	specificity	NN
cord-001835-0s7ok4uw	4178	26	.	.	.
cord-001835-0s7ok4uw	4179	1	Further	further	RB
cord-001835-0s7ok4uw	4179	2	,	,	,
cord-001835-0s7ok4uw	4179	3	a	a	DT
cord-001835-0s7ok4uw	4179	4	PduA	pdua	NN
cord-001835-0s7ok4uw	4179	5	permutation	permutation	NN
cord-001835-0s7ok4uw	4179	6	(	(	-LRB-
cord-001835-0s7ok4uw	4179	7	PduAp	PduAp	NNP
cord-001835-0s7ok4uw	4179	8	)	)	-RRB-
cord-001835-0s7ok4uw	4179	9	has	have	VBZ
cord-001835-0s7ok4uw	4179	10	resulted	result	VBN
cord-001835-0s7ok4uw	4179	11	in	in	IN
cord-001835-0s7ok4uw	4179	12	a	a	DT
cord-001835-0s7ok4uw	4179	13	closed	closed	JJ
cord-001835-0s7ok4uw	4179	14	icosahedral	icosahedral	JJ
cord-001835-0s7ok4uw	4179	15	cage	cage	NN
cord-001835-0s7ok4uw	4179	16	.	.	.
cord-001835-0s7ok4uw	4180	1	This	this	DT
cord-001835-0s7ok4uw	4180	2	novel	novel	NN
cord-001835-0s7ok4uw	4180	3	PduAp	PduAp	NNP
cord-001835-0s7ok4uw	4180	4	cage	cage	NN
cord-001835-0s7ok4uw	4180	5	shows	show	VBZ
cord-001835-0s7ok4uw	4180	6	a	a	DT
cord-001835-0s7ok4uw	4180	7	pH	ph	NN
cord-001835-0s7ok4uw	4180	8	and	and	CC
cord-001835-0s7ok4uw	4180	9	salt	salt	NN
cord-001835-0s7ok4uw	4180	10	dependent	dependent	JJ
cord-001835-0s7ok4uw	4180	11	assembly	assembly	NN
cord-001835-0s7ok4uw	4180	12	and	and	CC
cord-001835-0s7ok4uw	4180	13	may	may	MD
cord-001835-0s7ok4uw	4180	14	serve	serve	VB
cord-001835-0s7ok4uw	4180	15	as	as	IN
cord-001835-0s7ok4uw	4180	16	a	a	DT
cord-001835-0s7ok4uw	4180	17	reaction	reaction	NN
cord-001835-0s7ok4uw	4180	18	vessel	vessel	NN
cord-001835-0s7ok4uw	4180	19	or	or	CC
cord-001835-0s7ok4uw	4180	20	be	be	VB
cord-001835-0s7ok4uw	4180	21	utilized	utilize	VBN
cord-001835-0s7ok4uw	4180	22	for	for	IN
cord-001835-0s7ok4uw	4180	23	cargo	cargo	NN
cord-001835-0s7ok4uw	4180	24	delivery	delivery	NN
cord-001835-0s7ok4uw	4180	25	.	.	.
cord-001835-0s7ok4uw	4181	1	(	(	-LRB-
cord-001835-0s7ok4uw	4181	2	1	1	CD
cord-001835-0s7ok4uw	4181	3	,	,	,
cord-001835-0s7ok4uw	4181	4	2	2	CD
cord-001835-0s7ok4uw	4181	5	)	)	-RRB-
cord-001835-0s7ok4uw	4181	6	.	.	.
cord-001835-0s7ok4uw	4182	1	ANM	ANM	NNP
cord-001835-0s7ok4uw	4182	2	-	-	HYPH
cord-001835-0s7ok4uw	4182	3	MC	MC	NNP
cord-001835-0s7ok4uw	4182	4	is	be	VBZ
cord-001835-0s7ok4uw	4182	5	used	use	VBN
cord-001835-0s7ok4uw	4182	6	to	to	TO
cord-001835-0s7ok4uw	4182	7	identify	identify	VB
cord-001835-0s7ok4uw	4182	8	targeted	target	VBN
cord-001835-0s7ok4uw	4182	9	transition	transition	NN
cord-001835-0s7ok4uw	4182	10	pathways	pathway	NNS
cord-001835-0s7ok4uw	4182	11	and	and	CC
cord-001835-0s7ok4uw	4182	12	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	4182	13	between	between	IN
cord-001835-0s7ok4uw	4182	14	open	open	JJ
cord-001835-0s7ok4uw	4182	15	and	and	CC
cord-001835-0s7ok4uw	4182	16	closed	closed	JJ
cord-001835-0s7ok4uw	4182	17	states	state	NNS
cord-001835-0s7ok4uw	4182	18	of	of	IN
cord-001835-0s7ok4uw	4182	19	proteins	protein	NNS
cord-001835-0s7ok4uw	4182	20	.	.	.
cord-001835-0s7ok4uw	4183	1	At	at	IN
cord-001835-0s7ok4uw	4183	2	each	each	DT
cord-001835-0s7ok4uw	4183	3	step	step	NN
cord-001835-0s7ok4uw	4183	4	of	of	IN
cord-001835-0s7ok4uw	4183	5	this	this	DT
cord-001835-0s7ok4uw	4183	6	iterative	iterative	JJ
cord-001835-0s7ok4uw	4183	7	technique	technique	NN
cord-001835-0s7ok4uw	4183	8	,	,	,
cord-001835-0s7ok4uw	4183	9	the	the	DT
cord-001835-0s7ok4uw	4183	10	protein	protein	NN
cord-001835-0s7ok4uw	4183	11	is	be	VBZ
cord-001835-0s7ok4uw	4183	12	deformed	deform	VBN
cord-001835-0s7ok4uw	4183	13	along	along	IN
cord-001835-0s7ok4uw	4183	14	the	the	DT
cord-001835-0s7ok4uw	4183	15	collective	collective	JJ
cord-001835-0s7ok4uw	4183	16	ANM	anm	NN
cord-001835-0s7ok4uw	4183	17	mode	mode	NN
cord-001835-0s7ok4uw	4183	18	showing	show	VBG
cord-001835-0s7ok4uw	4183	19	the	the	DT
cord-001835-0s7ok4uw	4183	20	best	good	JJS
cord-001835-0s7ok4uw	4183	21	overlap	overlap	NN
cord-001835-0s7ok4uw	4183	22	with	with	IN
cord-001835-0s7ok4uw	4183	23	the	the	DT
cord-001835-0s7ok4uw	4183	24	target	target	NN
cord-001835-0s7ok4uw	4183	25	direction	direction	NN
cord-001835-0s7ok4uw	4183	26	and	and	CC
cord-001835-0s7ok4uw	4183	27	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4183	28	energy	energy	NN
cord-001835-0s7ok4uw	4183	29	is	be	VBZ
cord-001835-0s7ok4uw	4183	30	minimized	minimize	VBN
cord-001835-0s7ok4uw	4183	31	via	via	IN
cord-001835-0s7ok4uw	4183	32	short	short	JJ
cord-001835-0s7ok4uw	4183	33	MC	MC	NNP
cord-001835-0s7ok4uw	4183	34	run	run	VB
cord-001835-0s7ok4uw	4183	35	.	.	.
cord-001835-0s7ok4uw	4184	1	In	in	IN
cord-001835-0s7ok4uw	4184	2	this	this	DT
cord-001835-0s7ok4uw	4184	3	work	work	NN
cord-001835-0s7ok4uw	4184	4	,	,	,
cord-001835-0s7ok4uw	4184	5	optimization	optimization	NN
cord-001835-0s7ok4uw	4184	6	of	of	IN
cord-001835-0s7ok4uw	4184	7	simulation	simulation	NN
cord-001835-0s7ok4uw	4184	8	parameters	parameter	NNS
cord-001835-0s7ok4uw	4184	9	(	(	-LRB-
cord-001835-0s7ok4uw	4184	10	number	number	NN
cord-001835-0s7ok4uw	4184	11	of	of	IN
cord-001835-0s7ok4uw	4184	12	MC	MC	NNP
cord-001835-0s7ok4uw	4184	13	moves	move	NNS
cord-001835-0s7ok4uw	4184	14	and	and	CC
cord-001835-0s7ok4uw	4184	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4184	16	perturbation	perturbation	NN
cord-001835-0s7ok4uw	4184	17	strength	strength	NN
cord-001835-0s7ok4uw	4184	18	,	,	,
cord-001835-0s7ok4uw	4184	19	ANM	ANM	NNP
cord-001835-0s7ok4uw	4184	20	deformation	deformation	NN
cord-001835-0s7ok4uw	4184	21	factor	factor	NN
cord-001835-0s7ok4uw	4184	22	in	in	IN
cord-001835-0s7ok4uw	4184	23	each	each	DT
cord-001835-0s7ok4uw	4184	24	cycle	cycle	NN
cord-001835-0s7ok4uw	4184	25	and	and	CC
cord-001835-0s7ok4uw	4184	26	force	force	NN
cord-001835-0s7ok4uw	4184	27	constant	constant	JJ
cord-001835-0s7ok4uw	4184	28	for	for	IN
cord-001835-0s7ok4uw	4184	29	backbone	backbone	NN
cord-001835-0s7ok4uw	4184	30	bonds	bond	NNS
cord-001835-0s7ok4uw	4184	31	)	)	-RRB-
cord-001835-0s7ok4uw	4184	32	was	be	VBD
cord-001835-0s7ok4uw	4184	33	performed	perform	VBN
cord-001835-0s7ok4uw	4184	34	in	in	IN
cord-001835-0s7ok4uw	4184	35	order	order	NN
cord-001835-0s7ok4uw	4184	36	to	to	TO
cord-001835-0s7ok4uw	4184	37	increase	increase	VB
cord-001835-0s7ok4uw	4184	38	the	the	DT
cord-001835-0s7ok4uw	4184	39	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4184	40	of	of	IN
cord-001835-0s7ok4uw	4184	41	this	this	DT
cord-001835-0s7ok4uw	4184	42	technique	technique	NN
cord-001835-0s7ok4uw	4184	43	.	.	.
cord-001835-0s7ok4uw	4185	1	As	as	IN
cord-001835-0s7ok4uw	4185	2	a	a	DT
cord-001835-0s7ok4uw	4185	3	result	result	NN
cord-001835-0s7ok4uw	4185	4	,	,	,
cord-001835-0s7ok4uw	4185	5	this	this	DT
cord-001835-0s7ok4uw	4185	6	technique	technique	NN
cord-001835-0s7ok4uw	4185	7	can	can	MD
cord-001835-0s7ok4uw	4185	8	now	now	RB
cord-001835-0s7ok4uw	4185	9	be	be	VB
cord-001835-0s7ok4uw	4185	10	applied	apply	VBN
cord-001835-0s7ok4uw	4185	11	to	to	IN
cord-001835-0s7ok4uw	4185	12	much	much	RB
cord-001835-0s7ok4uw	4185	13	larger	large	JJR
cord-001835-0s7ok4uw	4185	14	systems	system	NNS
cord-001835-0s7ok4uw	4185	15	and	and	CC
cord-001835-0s7ok4uw	4185	16	conformational	conformational	JJ
cord-001835-0s7ok4uw	4185	17	changes	change	NNS
cord-001835-0s7ok4uw	4185	18	.	.	.
cord-001835-0s7ok4uw	4186	1	The	the	DT
cord-001835-0s7ok4uw	4186	2	transition	transition	NN
cord-001835-0s7ok4uw	4186	3	pathway	pathway	NN
cord-001835-0s7ok4uw	4186	4	between	between	IN
cord-001835-0s7ok4uw	4186	5	apo	apo	NNP
cord-001835-0s7ok4uw	4186	6	and	and	CC
cord-001835-0s7ok4uw	4186	7	DNA	DNA	NNP
cord-001835-0s7ok4uw	4186	8	-	-	HYPH
cord-001835-0s7ok4uw	4186	9	bound	bind	VBN
cord-001835-0s7ok4uw	4186	10	conformations	conformation	NNS
cord-001835-0s7ok4uw	4186	11	of	of	IN
cord-001835-0s7ok4uw	4186	12	the	the	DT
cord-001835-0s7ok4uw	4186	13	yeast	yeast	NN
cord-001835-0s7ok4uw	4186	14	RNA	RNA	NNP
cord-001835-0s7ok4uw	4186	15	polymerase	polymerase	NN
cord-001835-0s7ok4uw	4186	16	,	,	,
cord-001835-0s7ok4uw	4186	17	which	which	WDT
cord-001835-0s7ok4uw	4186	18	is	be	VBZ
cord-001835-0s7ok4uw	4186	19	a	a	DT
cord-001835-0s7ok4uw	4186	20	hetero-10-mer	hetero-10-mer	XX
cord-001835-0s7ok4uw	4186	21	with	with	IN
cord-001835-0s7ok4uw	4186	22	more	more	JJR
cord-001835-0s7ok4uw	4186	23	than	than	IN
cord-001835-0s7ok4uw	4186	24	3500	3500	CD
cord-001835-0s7ok4uw	4186	25	residues	residue	NNS
cord-001835-0s7ok4uw	4186	26	,	,	,
cord-001835-0s7ok4uw	4186	27	will	will	MD
cord-001835-0s7ok4uw	4186	28	be	be	VB
cord-001835-0s7ok4uw	4186	29	presented	present	VBN
cord-001835-0s7ok4uw	4186	30	here	here	RB
cord-001835-0s7ok4uw	4186	31	.	.	.
cord-001835-0s7ok4uw	4187	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	4187	2	,	,	,
cord-001835-0s7ok4uw	4187	3	the	the	DT
cord-001835-0s7ok4uw	4187	4	pathway	pathway	NN
cord-001835-0s7ok4uw	4187	5	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	4187	6	for	for	IN
cord-001835-0s7ok4uw	4187	7	more	more	JJR
cord-001835-0s7ok4uw	4187	8	than	than	IN
cord-001835-0s7ok4uw	4187	9	10	10	CD
cord-001835-0s7ok4uw	4187	10	diverse	diverse	JJ
cord-001835-0s7ok4uw	4187	11	proteins	protein	NNS
cord-001835-0s7ok4uw	4187	12	were	be	VBD
cord-001835-0s7ok4uw	4187	13	analyzed	analyze	VBN
cord-001835-0s7ok4uw	4187	14	in	in	IN
cord-001835-0s7ok4uw	4187	15	terms	term	NNS
cord-001835-0s7ok4uw	4187	16	of	of	IN
cord-001835-0s7ok4uw	4187	17	changes	change	NNS
cord-001835-0s7ok4uw	4187	18	in	in	IN
cord-001835-0s7ok4uw	4187	19	local	local	JJ
cord-001835-0s7ok4uw	4187	20	strain	strain	NN
cord-001835-0s7ok4uw	4187	21	energy	energy	NN
cord-001835-0s7ok4uw	4187	22	and	and	CC
cord-001835-0s7ok4uw	4187	23	backbone	backbone	NN
cord-001835-0s7ok4uw	4187	24	torsional	torsional	JJ
cord-001835-0s7ok4uw	4187	25	angles	angle	NNS
cord-001835-0s7ok4uw	4187	26	during	during	IN
cord-001835-0s7ok4uw	4187	27	apo	apo	NNP
cord-001835-0s7ok4uw	4187	28	-	-	HYPH
cord-001835-0s7ok4uw	4187	29	to	to	IN
cord-001835-0s7ok4uw	4187	30	-	-	HYPH
cord-001835-0s7ok4uw	4187	31	complex	complex	JJ
cord-001835-0s7ok4uw	4187	32	transitions	transition	NNS
cord-001835-0s7ok4uw	4187	33	.	.	.
cord-001835-0s7ok4uw	4188	1	Certain	certain	JJ
cord-001835-0s7ok4uw	4188	2	residues	residue	NNS
cord-001835-0s7ok4uw	4188	3	interacting	interact	VBG
cord-001835-0s7ok4uw	4188	4	with	with	IN
cord-001835-0s7ok4uw	4188	5	the	the	DT
cord-001835-0s7ok4uw	4188	6	ligand	ligand	NN
cord-001835-0s7ok4uw	4188	7	are	be	VBP
cord-001835-0s7ok4uw	4188	8	detected	detect	VBN
cord-001835-0s7ok4uw	4188	9	to	to	TO
cord-001835-0s7ok4uw	4188	10	exhibit	exhibit	VB
cord-001835-0s7ok4uw	4188	11	large	large	JJ
cord-001835-0s7ok4uw	4188	12	changes	change	NNS
cord-001835-0s7ok4uw	4188	13	with	with	IN
cord-001835-0s7ok4uw	4188	14	respect	respect	NN
cord-001835-0s7ok4uw	4188	15	to	to	IN
cord-001835-0s7ok4uw	4188	16	any	any	DT
cord-001835-0s7ok4uw	4188	17	of	of	IN
cord-001835-0s7ok4uw	4188	18	these	these	DT
cord-001835-0s7ok4uw	4188	19	two	two	CD
cord-001835-0s7ok4uw	4188	20	parameters	parameter	NNS
cord-001835-0s7ok4uw	4188	21	for	for	IN
cord-001835-0s7ok4uw	4188	22	more	more	JJR
cord-001835-0s7ok4uw	4188	23	than	than	IN
cord-001835-0s7ok4uw	4188	24	half	half	NN
cord-001835-0s7ok4uw	4188	25	of	of	IN
cord-001835-0s7ok4uw	4188	26	the	the	DT
cord-001835-0s7ok4uw	4188	27	proteins	protein	NNS
cord-001835-0s7ok4uw	4188	28	in	in	IN
cord-001835-0s7ok4uw	4188	29	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4188	30	dataset	dataset	NN
cord-001835-0s7ok4uw	4188	31	.	.	.
cord-001835-0s7ok4uw	4189	1	Department	Department	NNP
cord-001835-0s7ok4uw	4189	2	of	of	IN
cord-001835-0s7ok4uw	4189	3	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	4189	4	and	and	CC
cord-001835-0s7ok4uw	4189	5	Chemical	Chemical	NNP
cord-001835-0s7ok4uw	4189	6	Biology	Biology	NNP
cord-001835-0s7ok4uw	4189	7	,	,	,
cord-001835-0s7ok4uw	4189	8	Harvard	Harvard	NNP
cord-001835-0s7ok4uw	4189	9	University	University	NNP
cord-001835-0s7ok4uw	4189	10	,	,	,
cord-001835-0s7ok4uw	4189	11	2	2	CD
cord-001835-0s7ok4uw	4189	12	Howard	Howard	NNP
cord-001835-0s7ok4uw	4189	13	Hughes	Hughes	NNP
cord-001835-0s7ok4uw	4189	14	Medical	Medical	NNP
cord-001835-0s7ok4uw	4189	15	Institute	Institute	NNP
cord-001835-0s7ok4uw	4189	16	,	,	,
cord-001835-0s7ok4uw	4189	17	Harvard	Harvard	NNP
cord-001835-0s7ok4uw	4189	18	University	University	NNP
cord-001835-0s7ok4uw	4189	19	,	,	,
cord-001835-0s7ok4uw	4189	20	3	3	CD
cord-001835-0s7ok4uw	4189	21	 	 	_SP
cord-001835-0s7ok4uw	4189	22	Transgenic	transgenic	JJ
cord-001835-0s7ok4uw	4189	23	crops	crop	NNS
cord-001835-0s7ok4uw	4189	24	have	have	VBP
cord-001835-0s7ok4uw	4189	25	radically	radically	RB
cord-001835-0s7ok4uw	4189	26	reshaped	reshape	VBN
cord-001835-0s7ok4uw	4189	27	the	the	DT
cord-001835-0s7ok4uw	4189	28	agricultural	agricultural	JJ
cord-001835-0s7ok4uw	4189	29	landscape	landscape	NN
cord-001835-0s7ok4uw	4189	30	.	.	.
cord-001835-0s7ok4uw	4190	1	Since	since	IN
cord-001835-0s7ok4uw	4190	2	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4190	3	introduction	introduction	NN
cord-001835-0s7ok4uw	4190	4	in	in	IN
cord-001835-0s7ok4uw	4190	5	the	the	DT
cord-001835-0s7ok4uw	4190	6	late	late	JJ
cord-001835-0s7ok4uw	4190	7	1990s	1990	NNS
cord-001835-0s7ok4uw	4190	8	,	,	,
cord-001835-0s7ok4uw	4190	9	transgenic	transgenic	JJ
cord-001835-0s7ok4uw	4190	10	crops	crop	NNS
cord-001835-0s7ok4uw	4190	11	have	have	VBP
cord-001835-0s7ok4uw	4190	12	affected	affect	VBN
cord-001835-0s7ok4uw	4190	13	economic	economic	JJ
cord-001835-0s7ok4uw	4190	14	gains	gain	NNS
cord-001835-0s7ok4uw	4190	15	greater	great	JJR
cord-001835-0s7ok4uw	4190	16	than	than	IN
cord-001835-0s7ok4uw	4190	17	US$	us$	$
cord-001835-0s7ok4uw	4190	18	110	110	CD
cord-001835-0s7ok4uw	4190	19	billion	billion	CD
cord-001835-0s7ok4uw	4190	20	globally	globally	RB
cord-001835-0s7ok4uw	4190	21	due	due	JJ
cord-001835-0s7ok4uw	4190	22	to	to	IN
cord-001835-0s7ok4uw	4190	23	reduced	reduce	VBN
cord-001835-0s7ok4uw	4190	24	production	production	NN
cord-001835-0s7ok4uw	4190	25	costs	cost	NNS
cord-001835-0s7ok4uw	4190	26	and	and	CC
cord-001835-0s7ok4uw	4190	27	increased	increase	VBN
cord-001835-0s7ok4uw	4190	28	yield	yield	NN
cord-001835-0s7ok4uw	4190	29	gains	gain	NNS
cord-001835-0s7ok4uw	4190	30	.	.	.
cord-001835-0s7ok4uw	4191	1	Crops	crop	NNS
cord-001835-0s7ok4uw	4191	2	modified	modify	VBN
cord-001835-0s7ok4uw	4191	3	to	to	TO
cord-001835-0s7ok4uw	4191	4	produce	produce	VB
cord-001835-0s7ok4uw	4191	5	biological	biological	JJ
cord-001835-0s7ok4uw	4191	6	insecticides	insecticide	NNS
cord-001835-0s7ok4uw	4191	7	derived	derive	VBN
cord-001835-0s7ok4uw	4191	8	from	from	IN
cord-001835-0s7ok4uw	4191	9	the	the	DT
cord-001835-0s7ok4uw	4191	10	soil	soil	NN
cord-001835-0s7ok4uw	4191	11	bacterium	bacterium	NN
cord-001835-0s7ok4uw	4191	12	Bacillus	bacillus	NN
cord-001835-0s7ok4uw	4191	13	thuringiensis	thuringiensis	NN
cord-001835-0s7ok4uw	4191	14	(	(	-LRB-
cord-001835-0s7ok4uw	4191	15	Bt	Bt	NNP
cord-001835-0s7ok4uw	4191	16	)	)	-RRB-
cord-001835-0s7ok4uw	4191	17	are	be	VBP
cord-001835-0s7ok4uw	4191	18	among	among	IN
cord-001835-0s7ok4uw	4191	19	the	the	DT
cord-001835-0s7ok4uw	4191	20	most	most	RBS
cord-001835-0s7ok4uw	4191	21	robust	robust	JJ
cord-001835-0s7ok4uw	4191	22	methods	method	NNS
cord-001835-0s7ok4uw	4191	23	of	of	IN
cord-001835-0s7ok4uw	4191	24	pest	pest	NN
cord-001835-0s7ok4uw	4191	25	control	control	NN
cord-001835-0s7ok4uw	4191	26	.	.	.
cord-001835-0s7ok4uw	4192	1	Bt	Bt	NNP
cord-001835-0s7ok4uw	4192	2	toxins	toxin	NNS
cord-001835-0s7ok4uw	4192	3	offer	offer	VBP
cord-001835-0s7ok4uw	4192	4	many	many	JJ
cord-001835-0s7ok4uw	4192	5	advantages	advantage	NNS
cord-001835-0s7ok4uw	4192	6	over	over	IN
cord-001835-0s7ok4uw	4192	7	traditional	traditional	JJ
cord-001835-0s7ok4uw	4192	8	insecticides	insecticide	NNS
cord-001835-0s7ok4uw	4192	9	,	,	,
cord-001835-0s7ok4uw	4192	10	chiefly	chiefly	RB
cord-001835-0s7ok4uw	4192	11	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4192	12	inability	inability	NN
cord-001835-0s7ok4uw	4192	13	to	to	TO
cord-001835-0s7ok4uw	4192	14	affect	affect	VB
cord-001835-0s7ok4uw	4192	15	human	human	JJ
cord-001835-0s7ok4uw	4192	16	biology	biology	NN
cord-001835-0s7ok4uw	4192	17	and	and	CC
cord-001835-0s7ok4uw	4192	18	exquisite	exquisite	JJ
cord-001835-0s7ok4uw	4192	19	selectivity	selectivity	NN
cord-001835-0s7ok4uw	4192	20	for	for	IN
cord-001835-0s7ok4uw	4192	21	defined	define	VBN
cord-001835-0s7ok4uw	4192	22	pest	pest	NN
cord-001835-0s7ok4uw	4192	23	species	specie	NNS
cord-001835-0s7ok4uw	4192	24	.	.	.
cord-001835-0s7ok4uw	4193	1	However	however	RB
cord-001835-0s7ok4uw	4193	2	,	,	,
cord-001835-0s7ok4uw	4193	3	the	the	DT
cord-001835-0s7ok4uw	4193	4	evolution	evolution	NN
cord-001835-0s7ok4uw	4193	5	of	of	IN
cord-001835-0s7ok4uw	4193	6	resistance	resistance	NN
cord-001835-0s7ok4uw	4193	7	to	to	IN
cord-001835-0s7ok4uw	4193	8	Bacillus	bacillus	NN
cord-001835-0s7ok4uw	4193	9	thuringiensis	thuringiensis	NN
cord-001835-0s7ok4uw	4193	10	oendotoxins	oendotoxin	NNS
cord-001835-0s7ok4uw	4193	11	(	(	-LRB-
cord-001835-0s7ok4uw	4193	12	Bt	Bt	NNP
cord-001835-0s7ok4uw	4193	13	toxins	toxin	NNS
cord-001835-0s7ok4uw	4193	14	)	)	-RRB-
cord-001835-0s7ok4uw	4193	15	in	in	IN
cord-001835-0s7ok4uw	4193	16	insects	insect	NNS
cord-001835-0s7ok4uw	4193	17	has	have	VBZ
cord-001835-0s7ok4uw	4193	18	been	be	VBN
cord-001835-0s7ok4uw	4193	19	widely	widely	RB
cord-001835-0s7ok4uw	4193	20	observed	observe	VBN
cord-001835-0s7ok4uw	4193	21	in	in	IN
cord-001835-0s7ok4uw	4193	22	the	the	DT
cord-001835-0s7ok4uw	4193	23	field	field	NN
cord-001835-0s7ok4uw	4193	24	,	,	,
cord-001835-0s7ok4uw	4193	25	and	and	CC
cord-001835-0s7ok4uw	4193	26	greatly	greatly	RB
cord-001835-0s7ok4uw	4193	27	threatens	threaten	VBZ
cord-001835-0s7ok4uw	4193	28	the	the	DT
cord-001835-0s7ok4uw	4193	29	use	use	NN
cord-001835-0s7ok4uw	4193	30	of	of	IN
cord-001835-0s7ok4uw	4193	31	this	this	DT
cord-001835-0s7ok4uw	4193	32	mechanism	mechanism	NN
cord-001835-0s7ok4uw	4193	33	of	of	IN
cord-001835-0s7ok4uw	4193	34	pest	pest	NN
cord-001835-0s7ok4uw	4193	35	control	control	NN
cord-001835-0s7ok4uw	4193	36	in	in	IN
cord-001835-0s7ok4uw	4193	37	the	the	DT
cord-001835-0s7ok4uw	4193	38	future	future	NN
cord-001835-0s7ok4uw	4193	39	.	.	.
cord-001835-0s7ok4uw	4194	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4194	2	developed	develop	VBD
cord-001835-0s7ok4uw	4194	3	a	a	DT
cord-001835-0s7ok4uw	4194	4	Phage	Phage	NNP
cord-001835-0s7ok4uw	4194	5	-	-	HYPH
cord-001835-0s7ok4uw	4194	6	Assisted	Assisted	NNP
cord-001835-0s7ok4uw	4194	7	Continuous	Continuous	NNP
cord-001835-0s7ok4uw	4194	8	Evolution	Evolution	NNP
cord-001835-0s7ok4uw	4194	9	(	(	-LRB-
cord-001835-0s7ok4uw	4194	10	PACE	pace	NN
cord-001835-0s7ok4uw	4194	11	)	)	-RRB-
cord-001835-0s7ok4uw	4194	12	platform	platform	NN
cord-001835-0s7ok4uw	4194	13	for	for	IN
cord-001835-0s7ok4uw	4194	14	the	the	DT
cord-001835-0s7ok4uw	4194	15	rapid	rapid	JJ
cord-001835-0s7ok4uw	4194	16	generation	generation	NN
cord-001835-0s7ok4uw	4194	17	of	of	IN
cord-001835-0s7ok4uw	4194	18	high	high	JJ
cord-001835-0s7ok4uw	4194	19	-	-	HYPH
cord-001835-0s7ok4uw	4194	20	affinity	affinity	NN
cord-001835-0s7ok4uw	4194	21	protein	protein	NN
cord-001835-0s7ok4uw	4194	22	-	-	HYPH
cord-001835-0s7ok4uw	4194	23	protein	protein	NN
cord-001835-0s7ok4uw	4194	24	interactions	interaction	NNS
cord-001835-0s7ok4uw	4194	25	and	and	CC
cord-001835-0s7ok4uw	4194	26	validated	validate	VBD
cord-001835-0s7ok4uw	4194	27	the	the	DT
cord-001835-0s7ok4uw	4194	28	system	system	NN
cord-001835-0s7ok4uw	4194	29	by	by	IN
cord-001835-0s7ok4uw	4194	30	evolving	evolve	VBG
cord-001835-0s7ok4uw	4194	31	known	know	VBN
cord-001835-0s7ok4uw	4194	32	high	high	JJ
cord-001835-0s7ok4uw	4194	33	affinity	affinity	NN
cord-001835-0s7ok4uw	4194	34	antibody	antibody	NN
cord-001835-0s7ok4uw	4194	35	mimetics	mimetic	NNS
cord-001835-0s7ok4uw	4194	36	in	in	IN
cord-001835-0s7ok4uw	4194	37	<	<	NNP
cord-001835-0s7ok4uw	4194	38	5	5	CD
cord-001835-0s7ok4uw	4194	39	days	day	NNS
cord-001835-0s7ok4uw	4194	40	of	of	IN
cord-001835-0s7ok4uw	4194	41	PACE	pace	NN
cord-001835-0s7ok4uw	4194	42	.	.	.
cord-001835-0s7ok4uw	4195	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4195	2	applied	apply	VBD
cord-001835-0s7ok4uw	4195	3	this	this	DT
cord-001835-0s7ok4uw	4195	4	system	system	NN
cord-001835-0s7ok4uw	4195	5	to	to	IN
cord-001835-0s7ok4uw	4195	6	the	the	DT
cord-001835-0s7ok4uw	4195	7	evolution	evolution	NN
cord-001835-0s7ok4uw	4195	8	of	of	IN
cord-001835-0s7ok4uw	4195	9	the	the	DT
cord-001835-0s7ok4uw	4195	10	Bt	Bt	NNP
cord-001835-0s7ok4uw	4195	11	toxin	toxin	NN
cord-001835-0s7ok4uw	4195	12	protein	protein	NN
cord-001835-0s7ok4uw	4195	13	Cry1Ac	Cry1Ac	NNP
cord-001835-0s7ok4uw	4195	14	to	to	TO
cord-001835-0s7ok4uw	4195	15	recognize	recognize	VB
cord-001835-0s7ok4uw	4195	16	a	a	DT
cord-001835-0s7ok4uw	4195	17	non	non	JJ
cord-001835-0s7ok4uw	4195	18	-	-	JJ
cord-001835-0s7ok4uw	4195	19	cognate	cognate	JJ
cord-001835-0s7ok4uw	4195	20	cadherin	cadherin	NN
cord-001835-0s7ok4uw	4195	21	-	-	HYPH
cord-001835-0s7ok4uw	4195	22	like	like	JJ
cord-001835-0s7ok4uw	4195	23	receptor	receptor	NN
cord-001835-0s7ok4uw	4195	24	from	from	IN
cord-001835-0s7ok4uw	4195	25	Trichoplusia	Trichoplusia	NNP
cord-001835-0s7ok4uw	4195	26	ni	ni	NNP
cord-001835-0s7ok4uw	4195	27	,	,	,
cord-001835-0s7ok4uw	4195	28	a	a	DT
cord-001835-0s7ok4uw	4195	29	pest	pest	NN
cord-001835-0s7ok4uw	4195	30	for	for	IN
cord-001835-0s7ok4uw	4195	31	which	which	WDT
cord-001835-0s7ok4uw	4195	32	Bt	Bt	NNP
cord-001835-0s7ok4uw	4195	33	toxin	toxin	NN
cord-001835-0s7ok4uw	4195	34	resistance	resistance	NN
cord-001835-0s7ok4uw	4195	35	has	have	VBZ
cord-001835-0s7ok4uw	4195	36	been	be	VBN
cord-001835-0s7ok4uw	4195	37	observed	observe	VBN
cord-001835-0s7ok4uw	4195	38	in	in	IN
cord-001835-0s7ok4uw	4195	39	both	both	CC
cord-001835-0s7ok4uw	4195	40	the	the	DT
cord-001835-0s7ok4uw	4195	41	laboratory	laboratory	NN
cord-001835-0s7ok4uw	4195	42	and	and	CC
cord-001835-0s7ok4uw	4195	43	the	the	DT
cord-001835-0s7ok4uw	4195	44	field	field	NN
cord-001835-0s7ok4uw	4195	45	.	.	.
cord-001835-0s7ok4uw	4196	1	The	the	DT
cord-001835-0s7ok4uw	4196	2	resulting	result	VBG
cord-001835-0s7ok4uw	4196	3	evolved	evolve	VBD
cord-001835-0s7ok4uw	4196	4	Cry1Ac	Cry1Ac	NNP
cord-001835-0s7ok4uw	4196	5	variants	variant	NNS
cord-001835-0s7ok4uw	4196	6	exhibits	exhibit	VBZ
cord-001835-0s7ok4uw	4196	7	high	high	JJ
cord-001835-0s7ok4uw	4196	8	affinity	affinity	NN
cord-001835-0s7ok4uw	4196	9	for	for	IN
cord-001835-0s7ok4uw	4196	10	the	the	DT
cord-001835-0s7ok4uw	4196	11	target	target	NN
cord-001835-0s7ok4uw	4196	12	receptor	receptor	NN
cord-001835-0s7ok4uw	4196	13	,	,	,
cord-001835-0s7ok4uw	4196	14	and	and	CC
cord-001835-0s7ok4uw	4196	15	kill	kill	VB
cord-001835-0s7ok4uw	4196	16	insect	insect	NN
cord-001835-0s7ok4uw	4196	17	cells	cell	NNS
cord-001835-0s7ok4uw	4196	18	more	more	RBR
cord-001835-0s7ok4uw	4196	19	potently	potently	RB
cord-001835-0s7ok4uw	4196	20	than	than	IN
cord-001835-0s7ok4uw	4196	21	wild	wild	JJ
cord-001835-0s7ok4uw	4196	22	-	-	HYPH
cord-001835-0s7ok4uw	4196	23	type	type	NN
cord-001835-0s7ok4uw	4196	24	Cry1Ac	cry1ac	NN
cord-001835-0s7ok4uw	4196	25	.	.	.
cord-001835-0s7ok4uw	4197	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4197	2	findings	finding	NNS
cord-001835-0s7ok4uw	4197	3	establish	establish	VBP
cord-001835-0s7ok4uw	4197	4	that	that	IN
cord-001835-0s7ok4uw	4197	5	the	the	DT
cord-001835-0s7ok4uw	4197	6	directed	direct	VBN
cord-001835-0s7ok4uw	4197	7	evolution	evolution	NN
cord-001835-0s7ok4uw	4197	8	of	of	IN
cord-001835-0s7ok4uw	4197	9	novel	novel	JJ
cord-001835-0s7ok4uw	4197	10	receptor	receptor	NN
cord-001835-0s7ok4uw	4197	11	recognition	recognition	NN
cord-001835-0s7ok4uw	4197	12	in	in	IN
cord-001835-0s7ok4uw	4197	13	Bt	Bt	NNP
cord-001835-0s7ok4uw	4197	14	toxins	toxin	NNS
cord-001835-0s7ok4uw	4197	15	can	can	MD
cord-001835-0s7ok4uw	4197	16	be	be	VB
cord-001835-0s7ok4uw	4197	17	used	use	VBN
cord-001835-0s7ok4uw	4197	18	to	to	TO
cord-001835-0s7ok4uw	4197	19	target	target	VB
cord-001835-0s7ok4uw	4197	20	resistant	resistant	JJ
cord-001835-0s7ok4uw	4197	21	pests	pest	NNS
cord-001835-0s7ok4uw	4197	22	,	,	,
cord-001835-0s7ok4uw	4197	23	and	and	CC
cord-001835-0s7ok4uw	4197	24	has	have	VBZ
cord-001835-0s7ok4uw	4197	25	far	far	RB
cord-001835-0s7ok4uw	4197	26	-	-	HYPH
cord-001835-0s7ok4uw	4197	27	reaching	reach	VBG
cord-001835-0s7ok4uw	4197	28	implications	implication	NNS
cord-001835-0s7ok4uw	4197	29	for	for	IN
cord-001835-0s7ok4uw	4197	30	biological	biological	JJ
cord-001835-0s7ok4uw	4197	31	reagents	reagent	NNS
cord-001835-0s7ok4uw	4197	32	and	and	CC
cord-001835-0s7ok4uw	4197	33	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	4197	34	.	.	.
cord-001835-0s7ok4uw	4198	1	Optimization	optimization	NN
cord-001835-0s7ok4uw	4198	2	of	of	IN
cord-001835-0s7ok4uw	4198	3	a	a	DT
cord-001835-0s7ok4uw	4198	4	designed	design	VBN
cord-001835-0s7ok4uw	4198	5	protein	protein	NN
cord-001835-0s7ok4uw	4198	6	-	-	HYPH
cord-001835-0s7ok4uw	4198	7	protein	protein	NN
cord-001835-0s7ok4uw	4198	8	interface	interface	NN
cord-001835-0s7ok4uw	4198	9	Brian	Brian	NNP
cord-001835-0s7ok4uw	4198	10	Maniaci	Maniaci	NNP
cord-001835-0s7ok4uw	4198	11	1	1	CD
cord-001835-0s7ok4uw	4198	12	,	,	,
cord-001835-0s7ok4uw	4198	13	Collin	Collin	NNP
cord-001835-0s7ok4uw	4198	14	Lipper	Lipper	NNP
cord-001835-0s7ok4uw	4198	15	2	2	CD
cord-001835-0s7ok4uw	4198	16	,	,	,
cord-001835-0s7ok4uw	4198	17	John	John	NNP
cord-001835-0s7ok4uw	4198	18	J.	J.	NNP
cord-001835-0s7ok4uw	4198	19	Love	Love	NNP
cord-001835-0s7ok4uw	4198	20	1	1	CD
cord-001835-0s7ok4uw	4198	21	1	1	CD
cord-001835-0s7ok4uw	4198	22	San	San	NNP
cord-001835-0s7ok4uw	4198	23	Diego	Diego	NNP
cord-001835-0s7ok4uw	4198	24	State	State	NNP
cord-001835-0s7ok4uw	4198	25	University	University	NNP
cord-001835-0s7ok4uw	4198	26	,	,	,
cord-001835-0s7ok4uw	4198	27	2	2	CD
cord-001835-0s7ok4uw	4198	28	University	University	NNP
cord-001835-0s7ok4uw	4198	29	of	of	IN
cord-001835-0s7ok4uw	4198	30	California	California	NNP
cord-001835-0s7ok4uw	4198	31	Protein	Protein	NNP
cord-001835-0s7ok4uw	4198	32	-	-	HYPH
cord-001835-0s7ok4uw	4198	33	protein	protein	NN
cord-001835-0s7ok4uw	4198	34	interactions	interaction	NNS
cord-001835-0s7ok4uw	4198	35	play	play	VBP
cord-001835-0s7ok4uw	4198	36	key	key	JJ
cord-001835-0s7ok4uw	4198	37	roles	role	NNS
cord-001835-0s7ok4uw	4198	38	in	in	IN
cord-001835-0s7ok4uw	4198	39	practically	practically	RB
cord-001835-0s7ok4uw	4198	40	every	every	DT
cord-001835-0s7ok4uw	4198	41	biological	biological	JJ
cord-001835-0s7ok4uw	4198	42	process	process	NN
cord-001835-0s7ok4uw	4198	43	.	.	.
cord-001835-0s7ok4uw	4199	1	Protein	protein	NN
cord-001835-0s7ok4uw	4199	2	-	-	HYPH
cord-001835-0s7ok4uw	4199	3	protein	protein	NN
cord-001835-0s7ok4uw	4199	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	4199	5	vary	vary	VBP
cord-001835-0s7ok4uw	4199	6	with	with	IN
cord-001835-0s7ok4uw	4199	7	composition	composition	NN
cord-001835-0s7ok4uw	4199	8	,	,	,
cord-001835-0s7ok4uw	4199	9	affinity	affinity	NN
cord-001835-0s7ok4uw	4199	10	,	,	,
cord-001835-0s7ok4uw	4199	11	and	and	CC
cord-001835-0s7ok4uw	4199	12	lifetime	lifetime	NN
cord-001835-0s7ok4uw	4199	13	of	of	IN
cord-001835-0s7ok4uw	4199	14	the	the	DT
cord-001835-0s7ok4uw	4199	15	complex	complex	NN
cord-001835-0s7ok4uw	4199	16	.	.	.
cord-001835-0s7ok4uw	4200	1	Studying	study	VBG
cord-001835-0s7ok4uw	4200	2	designed	design	VBN
cord-001835-0s7ok4uw	4200	3	protein	protein	NN
cord-001835-0s7ok4uw	4200	4	-	-	HYPH
cord-001835-0s7ok4uw	4200	5	protein	protein	NN
cord-001835-0s7ok4uw	4200	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	4200	7	will	will	MD
cord-001835-0s7ok4uw	4200	8	provide	provide	VB
cord-001835-0s7ok4uw	4200	9	insight	insight	NN
cord-001835-0s7ok4uw	4200	10	into	into	IN
cord-001835-0s7ok4uw	4200	11	the	the	DT
cord-001835-0s7ok4uw	4200	12	underlying	underlie	VBG
cord-001835-0s7ok4uw	4200	13	principles	principle	NNS
cord-001835-0s7ok4uw	4200	14	of	of	IN
cord-001835-0s7ok4uw	4200	15	complex	complex	JJ
cord-001835-0s7ok4uw	4200	16	assembly	assembly	NN
cord-001835-0s7ok4uw	4200	17	and	and	CC
cord-001835-0s7ok4uw	4200	18	formation	formation	NN
cord-001835-0s7ok4uw	4200	19	.	.	.
cord-001835-0s7ok4uw	4201	1	Computational	computational	JJ
cord-001835-0s7ok4uw	4201	2	protein	protein	NN
cord-001835-0s7ok4uw	4201	3	docking	docking	NN
cord-001835-0s7ok4uw	4201	4	and	and	CC
cord-001835-0s7ok4uw	4201	5	amino	amino	NN
cord-001835-0s7ok4uw	4201	6	acid	acid	NN
cord-001835-0s7ok4uw	4201	7	sequence	sequence	NN
cord-001835-0s7ok4uw	4201	8	design	design	NN
cord-001835-0s7ok4uw	4201	9	were	be	VBD
cord-001835-0s7ok4uw	4201	10	used	use	VBN
cord-001835-0s7ok4uw	4201	11	previously	previously	RB
cord-001835-0s7ok4uw	4201	12	to	to	TO
cord-001835-0s7ok4uw	4201	13	generate	generate	VB
cord-001835-0s7ok4uw	4201	14	protein	protein	NN
cord-001835-0s7ok4uw	4201	15	dimers	dimer	NNS
cord-001835-0s7ok4uw	4201	16	from	from	IN
cord-001835-0s7ok4uw	4201	17	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	4201	18	proteins	protein	NNS
cord-001835-0s7ok4uw	4201	19	.	.	.
cord-001835-0s7ok4uw	4202	1	The	the	DT
cord-001835-0s7ok4uw	4202	2	normally	normally	RB
cord-001835-0s7ok4uw	4202	3	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	4202	4	b1	b1	NN
cord-001835-0s7ok4uw	4202	5	domain	domain	NN
cord-001835-0s7ok4uw	4202	6	of	of	IN
cord-001835-0s7ok4uw	4202	7	Streptococcal	Streptococcal	NNP
cord-001835-0s7ok4uw	4202	8	protein	protein	NN
cord-001835-0s7ok4uw	4202	9	-	-	HYPH
cord-001835-0s7ok4uw	4202	10	G	g	NN
cord-001835-0s7ok4uw	4202	11	(	(	-LRB-
cord-001835-0s7ok4uw	4202	12	GB1	GB1	NNP
cord-001835-0s7ok4uw	4202	13	)	)	-RRB-
cord-001835-0s7ok4uw	4202	14	was	be	VBD
cord-001835-0s7ok4uw	4202	15	computational	computational	JJ
cord-001835-0s7ok4uw	4202	16	docked	dock	VBN
cord-001835-0s7ok4uw	4202	17	to	to	IN
cord-001835-0s7ok4uw	4202	18	itself	-PRON-	PRP
cord-001835-0s7ok4uw	4202	19	,	,	,
cord-001835-0s7ok4uw	4202	20	followed	follow	VBN
cord-001835-0s7ok4uw	4202	21	by	by	IN
cord-001835-0s7ok4uw	4202	22	optimization	optimization	NN
cord-001835-0s7ok4uw	4202	23	of	of	IN
cord-001835-0s7ok4uw	4202	24	the	the	DT
cord-001835-0s7ok4uw	4202	25	interfacial	interfacial	JJ
cord-001835-0s7ok4uw	4202	26	side	side	NN
cord-001835-0s7ok4uw	4202	27	chains	chain	NNS
cord-001835-0s7ok4uw	4202	28	.	.	.
cord-001835-0s7ok4uw	4203	1	Two	two	CD
cord-001835-0s7ok4uw	4203	2	variants	variant	NNS
cord-001835-0s7ok4uw	4203	3	,	,	,
cord-001835-0s7ok4uw	4203	4	MonomerA	monomera	NN
cord-001835-0s7ok4uw	4203	5	and	and	CC
cord-001835-0s7ok4uw	4203	6	MonomerB	monomerb	NN
cord-001835-0s7ok4uw	4203	7	,	,	,
cord-001835-0s7ok4uw	4203	8	were	be	VBD
cord-001835-0s7ok4uw	4203	9	computationally	computationally	RB
cord-001835-0s7ok4uw	4203	10	derived	derive	VBN
cord-001835-0s7ok4uw	4203	11	as	as	IN
cord-001835-0s7ok4uw	4203	12	a	a	DT
cord-001835-0s7ok4uw	4203	13	result	result	NN
cord-001835-0s7ok4uw	4203	14	of	of	IN
cord-001835-0s7ok4uw	4203	15	a	a	DT
cord-001835-0s7ok4uw	4203	16	designed	design	VBN
cord-001835-0s7ok4uw	4203	17	protein	protein	NN
cord-001835-0s7ok4uw	4203	18	-	-	HYPH
cord-001835-0s7ok4uw	4203	19	protein	protein	NN
cord-001835-0s7ok4uw	4203	20	interface	interface	NN
cord-001835-0s7ok4uw	4203	21	.	.	.
cord-001835-0s7ok4uw	4204	1	These	these	DT
cord-001835-0s7ok4uw	4204	2	designed	design	VBN
cord-001835-0s7ok4uw	4204	3	proteins	protein	NNS
cord-001835-0s7ok4uw	4204	4	were	be	VBD
cord-001835-0s7ok4uw	4204	5	characterized	characterize	VBN
cord-001835-0s7ok4uw	4204	6	using	use	VBG
cord-001835-0s7ok4uw	4204	7	analytical	analytical	JJ
cord-001835-0s7ok4uw	4204	8	ultracentrifugation	ultracentrifugation	NN
cord-001835-0s7ok4uw	4204	9	and	and	CC
cord-001835-0s7ok4uw	4204	10	heteronuclear	heteronuclear	NN
cord-001835-0s7ok4uw	4204	11	NMR	NMR	NNP
cord-001835-0s7ok4uw	4204	12	techniques	technique	NNS
cord-001835-0s7ok4uw	4204	13	.	.	.
cord-001835-0s7ok4uw	4205	1	This	this	DT
cord-001835-0s7ok4uw	4205	2	design	design	NN
cord-001835-0s7ok4uw	4205	3	resulted	result	VBD
cord-001835-0s7ok4uw	4205	4	in	in	IN
cord-001835-0s7ok4uw	4205	5	a	a	DT
cord-001835-0s7ok4uw	4205	6	pair	pair	NN
cord-001835-0s7ok4uw	4205	7	of	of	IN
cord-001835-0s7ok4uw	4205	8	protein	protein	NN
cord-001835-0s7ok4uw	4205	9	monomers	monomer	NNS
cord-001835-0s7ok4uw	4205	10	that	that	WDT
cord-001835-0s7ok4uw	4205	11	formed	form	VBD
cord-001835-0s7ok4uw	4205	12	a	a	DT
cord-001835-0s7ok4uw	4205	13	heterodimer	heterodimer	NN
cord-001835-0s7ok4uw	4205	14	of	of	IN
cord-001835-0s7ok4uw	4205	15	modest	modest	JJ
cord-001835-0s7ok4uw	4205	16	binding	bind	VBG
cord-001835-0s7ok4uw	4205	17	affinity	affinity	NN
cord-001835-0s7ok4uw	4205	18	.	.	.
cord-001835-0s7ok4uw	4206	1	A	a	DT
cord-001835-0s7ok4uw	4206	2	tetrahedral	tetrahedral	JJ
cord-001835-0s7ok4uw	4206	3	metal	metal	NN
cord-001835-0s7ok4uw	4206	4	-	-	HYPH
cord-001835-0s7ok4uw	4206	5	templated	templated	JJ
cord-001835-0s7ok4uw	4206	6	interface	interface	NN
cord-001835-0s7ok4uw	4206	7	design	design	NN
cord-001835-0s7ok4uw	4206	8	strategy	strategy	NN
cord-001835-0s7ok4uw	4206	9	was	be	VBD
cord-001835-0s7ok4uw	4206	10	implemented	implement	VBN
cord-001835-0s7ok4uw	4206	11	in	in	IN
cord-001835-0s7ok4uw	4206	12	an	an	DT
cord-001835-0s7ok4uw	4206	13	attempt	attempt	NN
cord-001835-0s7ok4uw	4206	14	to	to	TO
cord-001835-0s7ok4uw	4206	15	strengthen	strengthen	VB
cord-001835-0s7ok4uw	4206	16	the	the	DT
cord-001835-0s7ok4uw	4206	17	MonomerA	monomera	NN
cord-001835-0s7ok4uw	4206	18	-	-	HYPH
cord-001835-0s7ok4uw	4206	19	MonomerB	monomerb	JJ
cord-001835-0s7ok4uw	4206	20	complex	complex	NN
cord-001835-0s7ok4uw	4206	21	by	by	IN
cord-001835-0s7ok4uw	4206	22	introducing	introduce	VBG
cord-001835-0s7ok4uw	4206	23	cross	cross	JJ
cord-001835-0s7ok4uw	4206	24	-	-	JJ
cord-001835-0s7ok4uw	4206	25	monomer	monomer	JJ
cord-001835-0s7ok4uw	4206	26	metal	metal	NN
cord-001835-0s7ok4uw	4206	27	coordination	coordination	NN
cord-001835-0s7ok4uw	4206	28	.	.	.
cord-001835-0s7ok4uw	4207	1	Another	another	DT
cord-001835-0s7ok4uw	4207	2	advantage	advantage	NN
cord-001835-0s7ok4uw	4207	3	of	of	IN
cord-001835-0s7ok4uw	4207	4	using	use	VBG
cord-001835-0s7ok4uw	4207	5	the	the	DT
cord-001835-0s7ok4uw	4207	6	metal	metal	NN
cord-001835-0s7ok4uw	4207	7	-	-	HYPH
cord-001835-0s7ok4uw	4207	8	templated	templated	JJ
cord-001835-0s7ok4uw	4207	9	interface	interface	NN
cord-001835-0s7ok4uw	4207	10	is	be	VBZ
cord-001835-0s7ok4uw	4207	11	the	the	DT
cord-001835-0s7ok4uw	4207	12	ability	ability	NN
cord-001835-0s7ok4uw	4207	13	to	to	TO
cord-001835-0s7ok4uw	4207	14	control	control	VB
cord-001835-0s7ok4uw	4207	15	the	the	DT
cord-001835-0s7ok4uw	4207	16	protein	protein	NN
cord-001835-0s7ok4uw	4207	17	-	-	HYPH
cord-001835-0s7ok4uw	4207	18	protein	protein	NN
cord-001835-0s7ok4uw	4207	19	interaction	interaction	NN
cord-001835-0s7ok4uw	4207	20	both	both	CC
cord-001835-0s7ok4uw	4207	21	temporarily	temporarily	RB
cord-001835-0s7ok4uw	4207	22	and	and	CC
cord-001835-0s7ok4uw	4207	23	spatially	spatially	RB
cord-001835-0s7ok4uw	4207	24	.	.	.
cord-001835-0s7ok4uw	4208	1	A	a	DT
cord-001835-0s7ok4uw	4208	2	number	number	NN
cord-001835-0s7ok4uw	4208	3	of	of	IN
cord-001835-0s7ok4uw	4208	4	newly	newly	RB
cord-001835-0s7ok4uw	4208	5	engineered	engineer	VBN
cord-001835-0s7ok4uw	4208	6	variants	variant	NNS
cord-001835-0s7ok4uw	4208	7	of	of	IN
cord-001835-0s7ok4uw	4208	8	Monomer	Monomer	NNP
cord-001835-0s7ok4uw	4208	9	A	A	NNP
cord-001835-0s7ok4uw	4208	10	and	and	CC
cord-001835-0s7ok4uw	4208	11	Monomer	Monomer	NNP
cord-001835-0s7ok4uw	4208	12	B	B	NNP
cord-001835-0s7ok4uw	4208	13	with	with	IN
cord-001835-0s7ok4uw	4208	14	metal	metal	NN
cord-001835-0s7ok4uw	4208	15	coordination	coordination	NN
cord-001835-0s7ok4uw	4208	16	sites	site	NNS
cord-001835-0s7ok4uw	4208	17	were	be	VBD
cord-001835-0s7ok4uw	4208	18	designed	design	VBN
cord-001835-0s7ok4uw	4208	19	,	,	,
cord-001835-0s7ok4uw	4208	20	produced	produce	VBN
cord-001835-0s7ok4uw	4208	21	,	,	,
cord-001835-0s7ok4uw	4208	22	and	and	CC
cord-001835-0s7ok4uw	4208	23	tested	test	VBN
cord-001835-0s7ok4uw	4208	24	for	for	IN
cord-001835-0s7ok4uw	4208	25	increased	increase	VBN
cord-001835-0s7ok4uw	4208	26	affinity	affinity	NN
cord-001835-0s7ok4uw	4208	27	of	of	IN
cord-001835-0s7ok4uw	4208	28	the	the	DT
cord-001835-0s7ok4uw	4208	29	protein	protein	NN
cord-001835-0s7ok4uw	4208	30	-	-	HYPH
cord-001835-0s7ok4uw	4208	31	protein	protein	NN
cord-001835-0s7ok4uw	4208	32	complex	complex	NN
cord-001835-0s7ok4uw	4208	33	.	.	.
cord-001835-0s7ok4uw	4209	1	While	while	IN
cord-001835-0s7ok4uw	4209	2	the	the	DT
cord-001835-0s7ok4uw	4209	3	generation	generation	NN
cord-001835-0s7ok4uw	4209	4	of	of	IN
cord-001835-0s7ok4uw	4209	5	a	a	DT
cord-001835-0s7ok4uw	4209	6	metal	metal	NN
cord-001835-0s7ok4uw	4209	7	-	-	HYPH
cord-001835-0s7ok4uw	4209	8	templated	templated	JJ
cord-001835-0s7ok4uw	4209	9	MonomerA	monomera	JJ
cord-001835-0s7ok4uw	4209	10	-	-	HYPH
cord-001835-0s7ok4uw	4209	11	MonomerB	monomerb	JJ
cord-001835-0s7ok4uw	4209	12	complex	complex	NN
cord-001835-0s7ok4uw	4209	13	was	be	VBD
cord-001835-0s7ok4uw	4209	14	unsuccessful	unsuccessful	JJ
cord-001835-0s7ok4uw	4209	15	,	,	,
cord-001835-0s7ok4uw	4209	16	we	-PRON-	PRP
cord-001835-0s7ok4uw	4209	17	were	be	VBD
cord-001835-0s7ok4uw	4209	18	able	able	JJ
cord-001835-0s7ok4uw	4209	19	to	to	TO
cord-001835-0s7ok4uw	4209	20	obtain	obtain	VB
cord-001835-0s7ok4uw	4209	21	MonomerA	monomera	PRP$
cord-001835-0s7ok4uw	4209	22	variants	variant	NNS
cord-001835-0s7ok4uw	4209	23	that	that	WDT
cord-001835-0s7ok4uw	4209	24	form	form	VBP
cord-001835-0s7ok4uw	4209	25	a	a	DT
cord-001835-0s7ok4uw	4209	26	homodimer	homodimer	JJ
cord-001835-0s7ok4uw	4209	27	assembly	assembly	NN
cord-001835-0s7ok4uw	4209	28	only	only	RB
cord-001835-0s7ok4uw	4209	29	in	in	IN
cord-001835-0s7ok4uw	4209	30	the	the	DT
cord-001835-0s7ok4uw	4209	31	presence	presence	NN
cord-001835-0s7ok4uw	4209	32	of	of	IN
cord-001835-0s7ok4uw	4209	33	Zinc	Zinc	NNP
cord-001835-0s7ok4uw	4209	34	(	(	-LRB-
cord-001835-0s7ok4uw	4209	35	II	II	NNP
cord-001835-0s7ok4uw	4209	36	)	)	-RRB-
cord-001835-0s7ok4uw	4209	37	ions	ion	NNS
cord-001835-0s7ok4uw	4209	38	.	.	.
cord-001835-0s7ok4uw	4210	1	The	the	DT
cord-001835-0s7ok4uw	4210	2	crystal	crystal	NN
cord-001835-0s7ok4uw	4210	3	structures	structure	NNS
cord-001835-0s7ok4uw	4210	4	of	of	IN
cord-001835-0s7ok4uw	4210	5	metal	metal	NN
cord-001835-0s7ok4uw	4210	6	-	-	HYPH
cord-001835-0s7ok4uw	4210	7	templated	templated	JJ
cord-001835-0s7ok4uw	4210	8	MonomerA	MonomerA	NNP
cord-001835-0s7ok4uw	4210	9	variants	variant	NNS
cord-001835-0s7ok4uw	4210	10	in	in	IN
cord-001835-0s7ok4uw	4210	11	the	the	DT
cord-001835-0s7ok4uw	4210	12	presence	presence	NN
cord-001835-0s7ok4uw	4210	13	of	of	IN
cord-001835-0s7ok4uw	4210	14	zinc	zinc	NN
cord-001835-0s7ok4uw	4210	15	provide	provide	VBP
cord-001835-0s7ok4uw	4210	16	an	an	DT
cord-001835-0s7ok4uw	4210	17	explanation	explanation	NN
cord-001835-0s7ok4uw	4210	18	for	for	IN
cord-001835-0s7ok4uw	4210	19	the	the	DT
cord-001835-0s7ok4uw	4210	20	observed	observed	JJ
cord-001835-0s7ok4uw	4210	21	dimer	dimer	NN
cord-001835-0s7ok4uw	4210	22	formation	formation	NN
cord-001835-0s7ok4uw	4210	23	.	.	.
cord-001835-0s7ok4uw	4211	1	The	the	DT
cord-001835-0s7ok4uw	4211	2	crystal	crystal	NN
cord-001835-0s7ok4uw	4211	3	structure	structure	NN
cord-001835-0s7ok4uw	4211	4	indicates	indicate	VBZ
cord-001835-0s7ok4uw	4211	5	that	that	IN
cord-001835-0s7ok4uw	4211	6	the	the	DT
cord-001835-0s7ok4uw	4211	7	protein	protein	NN
cord-001835-0s7ok4uw	4211	8	-	-	HYPH
cord-001835-0s7ok4uw	4211	9	protein	protein	NN
cord-001835-0s7ok4uw	4211	10	interaction	interaction	NN
cord-001835-0s7ok4uw	4211	11	is	be	VBZ
cord-001835-0s7ok4uw	4211	12	not	not	RB
cord-001835-0s7ok4uw	4211	13	driven	drive	VBN
cord-001835-0s7ok4uw	4211	14	by	by	IN
cord-001835-0s7ok4uw	4211	15	the	the	DT
cord-001835-0s7ok4uw	4211	16	designed	design	VBN
cord-001835-0s7ok4uw	4211	17	protein	protein	NN
cord-001835-0s7ok4uw	4211	18	interface	interface	NN
cord-001835-0s7ok4uw	4211	19	,	,	,
cord-001835-0s7ok4uw	4211	20	but	but	CC
cord-001835-0s7ok4uw	4211	21	rather	rather	RB
cord-001835-0s7ok4uw	4211	22	non	non	JJ
cord-001835-0s7ok4uw	4211	23	-	-	JJ
cord-001835-0s7ok4uw	4211	24	specific	specific	JJ
cord-001835-0s7ok4uw	4211	25	association	association	NN
cord-001835-0s7ok4uw	4211	26	via	via	IN
cord-001835-0s7ok4uw	4211	27	edge	edge	NN
cord-001835-0s7ok4uw	4211	28	-	-	HYPH
cord-001835-0s7ok4uw	4211	29	strand	strand	NN
cord-001835-0s7ok4uw	4211	30	interactions	interaction	NNS
cord-001835-0s7ok4uw	4211	31	.	.	.
cord-001835-0s7ok4uw	4212	1	New	new	JJ
cord-001835-0s7ok4uw	4212	2	variants	variant	NNS
cord-001835-0s7ok4uw	4212	3	were	be	VBD
cord-001835-0s7ok4uw	4212	4	designed	design	VBN
cord-001835-0s7ok4uw	4212	5	with	with	IN
cord-001835-0s7ok4uw	4212	6	the	the	DT
cord-001835-0s7ok4uw	4212	7	goal	goal	NN
cord-001835-0s7ok4uw	4212	8	of	of	IN
cord-001835-0s7ok4uw	4212	9	engineering	engineer	VBG
cord-001835-0s7ok4uw	4212	10	a	a	DT
cord-001835-0s7ok4uw	4212	11	high	high	JJ
cord-001835-0s7ok4uw	4212	12	affinity	affinity	NN
cord-001835-0s7ok4uw	4212	13	homodimer	homodimer	JJ
cord-001835-0s7ok4uw	4212	14	in	in	IN
cord-001835-0s7ok4uw	4212	15	a	a	DT
cord-001835-0s7ok4uw	4212	16	helix	helix	NN
cord-001835-0s7ok4uw	4212	17	-	-	HYPH
cord-001835-0s7ok4uw	4212	18	to	to	IN
cord-001835-0s7ok4uw	4212	19	-	-	HYPH
cord-001835-0s7ok4uw	4212	20	helix	helix	NN
cord-001835-0s7ok4uw	4212	21	orientation	orientation	NN
cord-001835-0s7ok4uw	4212	22	as	as	IN
cord-001835-0s7ok4uw	4212	23	the	the	DT
cord-001835-0s7ok4uw	4212	24	originally	originally	RB
cord-001835-0s7ok4uw	4212	25	designed	design	VBN
cord-001835-0s7ok4uw	4212	26	protein	protein	NN
cord-001835-0s7ok4uw	4212	27	-	-	HYPH
cord-001835-0s7ok4uw	4212	28	protein	protein	NN
cord-001835-0s7ok4uw	4212	29	interface	interface	NN
cord-001835-0s7ok4uw	4212	30	.	.	.
cord-001835-0s7ok4uw	4213	1	Current	current	JJ
cord-001835-0s7ok4uw	4213	2	evaluation	evaluation	NN
cord-001835-0s7ok4uw	4213	3	of	of	IN
cord-001835-0s7ok4uw	4213	4	MonomerA	monomera	JJ
cord-001835-0s7ok4uw	4213	5	variants	variant	NNS
cord-001835-0s7ok4uw	4213	6	for	for	IN
cord-001835-0s7ok4uw	4213	7	self	self	NN
cord-001835-0s7ok4uw	4213	8	-	-	HYPH
cord-001835-0s7ok4uw	4213	9	association	association	NN
cord-001835-0s7ok4uw	4213	10	via	via	IN
cord-001835-0s7ok4uw	4213	11	metal	metal	NN
cord-001835-0s7ok4uw	4213	12	coordination	coordination	NN
cord-001835-0s7ok4uw	4213	13	are	be	VBP
cord-001835-0s7ok4uw	4213	14	being	be	VBG
cord-001835-0s7ok4uw	4213	15	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	4213	16	using	use	VBG
cord-001835-0s7ok4uw	4213	17	size	size	NN
cord-001835-0s7ok4uw	4213	18	exclusion	exclusion	NN
cord-001835-0s7ok4uw	4213	19	chromatography	chromatography	NN
cord-001835-0s7ok4uw	4213	20	with	with	IN
cord-001835-0s7ok4uw	4213	21	a	a	DT
cord-001835-0s7ok4uw	4213	22	multi	multi	JJ
cord-001835-0s7ok4uw	4213	23	-	-	JJ
cord-001835-0s7ok4uw	4213	24	angle	angle	JJ
cord-001835-0s7ok4uw	4213	25	light	light	JJ
cord-001835-0s7ok4uw	4213	26	scattering	scattering	NN
cord-001835-0s7ok4uw	4213	27	detector	detector	NN
cord-001835-0s7ok4uw	4213	28	for	for	IN
cord-001835-0s7ok4uw	4213	29	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	4213	30	state	state	NN
cord-001835-0s7ok4uw	4213	31	quantification	quantification	NN
cord-001835-0s7ok4uw	4213	32	.	.	.
cord-001835-0s7ok4uw	4214	1	The	the	DT
cord-001835-0s7ok4uw	4214	2	results	result	NNS
cord-001835-0s7ok4uw	4214	3	of	of	IN
cord-001835-0s7ok4uw	4214	4	this	this	DT
cord-001835-0s7ok4uw	4214	5	protein	protein	NN
cord-001835-0s7ok4uw	4214	6	design	design	NN
cord-001835-0s7ok4uw	4214	7	project	project	NN
cord-001835-0s7ok4uw	4214	8	should	should	MD
cord-001835-0s7ok4uw	4214	9	lead	lead	VB
cord-001835-0s7ok4uw	4214	10	to	to	IN
cord-001835-0s7ok4uw	4214	11	a	a	DT
cord-001835-0s7ok4uw	4214	12	greater	great	JJR
cord-001835-0s7ok4uw	4214	13	understanding	understanding	NN
cord-001835-0s7ok4uw	4214	14	of	of	IN
cord-001835-0s7ok4uw	4214	15	the	the	DT
cord-001835-0s7ok4uw	4214	16	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	4214	17	parameters	parameter	NNS
cord-001835-0s7ok4uw	4214	18	that	that	WDT
cord-001835-0s7ok4uw	4214	19	drive	drive	VBP
cord-001835-0s7ok4uw	4214	20	natural	natural	JJ
cord-001835-0s7ok4uw	4214	21	protein	protein	NN
cord-001835-0s7ok4uw	4214	22	-	-	HYPH
cord-001835-0s7ok4uw	4214	23	protein	protein	NN
cord-001835-0s7ok4uw	4214	24	interactions	interaction	NNS
cord-001835-0s7ok4uw	4214	25	.	.	.
cord-001835-0s7ok4uw	4215	1	Continuous	continuous	JJ
cord-001835-0s7ok4uw	4215	2	evolution	evolution	NN
cord-001835-0s7ok4uw	4215	3	of	of	IN
cord-001835-0s7ok4uw	4215	4	site	site	NN
cord-001835-0s7ok4uw	4215	5	-	-	HYPH
cord-001835-0s7ok4uw	4215	6	specific	specific	JJ
cord-001835-0s7ok4uw	4215	7	recombinases	recombinase	NNS
cord-001835-0s7ok4uw	4215	8	with	with	IN
cord-001835-0s7ok4uw	4215	9	highly	highly	RB
cord-001835-0s7ok4uw	4215	10	reprogrammed	reprogramme	VBN
cord-001835-0s7ok4uw	4215	11	dna	dna	NN
cord-001835-0s7ok4uw	4215	12	specificities	specificity	NNS
cord-001835-0s7ok4uw	4216	1	The	the	DT
cord-001835-0s7ok4uw	4216	2	ability	ability	NN
cord-001835-0s7ok4uw	4216	3	to	to	TO
cord-001835-0s7ok4uw	4216	4	precisely	precisely	RB
cord-001835-0s7ok4uw	4216	5	modify	modify	VB
cord-001835-0s7ok4uw	4216	6	the	the	DT
cord-001835-0s7ok4uw	4216	7	genome	genome	NN
cord-001835-0s7ok4uw	4216	8	of	of	IN
cord-001835-0s7ok4uw	4216	9	human	human	JJ
cord-001835-0s7ok4uw	4216	10	cells	cell	NNS
cord-001835-0s7ok4uw	4216	11	has	have	VBZ
cord-001835-0s7ok4uw	4216	12	enormous	enormous	JJ
cord-001835-0s7ok4uw	4216	13	potential	potential	NN
cord-001835-0s7ok4uw	4216	14	as	as	IN
cord-001835-0s7ok4uw	4216	15	a	a	DT
cord-001835-0s7ok4uw	4216	16	novel	novel	JJ
cord-001835-0s7ok4uw	4216	17	therapy	therapy	NN
cord-001835-0s7ok4uw	4216	18	and	and	CC
cord-001835-0s7ok4uw	4216	19	a	a	DT
cord-001835-0s7ok4uw	4216	20	powerful	powerful	JJ
cord-001835-0s7ok4uw	4216	21	research	research	NN
cord-001835-0s7ok4uw	4216	22	tool	tool	NN
cord-001835-0s7ok4uw	4216	23	.	.	.
cord-001835-0s7ok4uw	4217	1	In	in	IN
cord-001835-0s7ok4uw	4217	2	contrast	contrast	NN
cord-001835-0s7ok4uw	4217	3	to	to	IN
cord-001835-0s7ok4uw	4217	4	reprogrammable	reprogrammable	JJ
cord-001835-0s7ok4uw	4217	5	nucleases	nuclease	NNS
cord-001835-0s7ok4uw	4217	6	,	,	,
cord-001835-0s7ok4uw	4217	7	such	such	JJ
cord-001835-0s7ok4uw	4217	8	as	as	IN
cord-001835-0s7ok4uw	4217	9	TALENs	talen	NNS
cord-001835-0s7ok4uw	4217	10	or	or	CC
cord-001835-0s7ok4uw	4217	11	a	a	DT
cord-001835-0s7ok4uw	4217	12	Cas9/	cas9/	NN
cord-001835-0s7ok4uw	4218	1	sgRNA	sgrna	CD
cord-001835-0s7ok4uw	4218	2	pair	pair	NN
cord-001835-0s7ok4uw	4218	3	-which	-which	JJS
cord-001835-0s7ok4uw	4218	4	specifically	specifically	RB
cord-001835-0s7ok4uw	4218	5	cleave	cleave	VB
cord-001835-0s7ok4uw	4218	6	DNA	dna	NN
cord-001835-0s7ok4uw	4218	7	but	but	CC
cord-001835-0s7ok4uw	4218	8	then	then	RB
cord-001835-0s7ok4uw	4218	9	rely	rely	VB
cord-001835-0s7ok4uw	4218	10	on	on	IN
cord-001835-0s7ok4uw	4218	11	stochastic	stochastic	JJ
cord-001835-0s7ok4uw	4218	12	host	host	NN
cord-001835-0s7ok4uw	4218	13	cells	cell	NNS
cord-001835-0s7ok4uw	4218	14	processes	process	NNS
cord-001835-0s7ok4uw	4218	15	to	to	TO
cord-001835-0s7ok4uw	4218	16	effect	effect	VB
cord-001835-0s7ok4uw	4219	1	gene	gene	NN
cord-001835-0s7ok4uw	4219	2	insertion	insertion	NN
cord-001835-0s7ok4uw	4219	3	-site	-site	IN
cord-001835-0s7ok4uw	4219	4	specific	specific	JJ
cord-001835-0s7ok4uw	4219	5	recombinases	recombinase	NNS
cord-001835-0s7ok4uw	4219	6	directly	directly	RB
cord-001835-0s7ok4uw	4219	7	catalyze	catalyze	VB
cord-001835-0s7ok4uw	4219	8	genomic	genomic	JJ
cord-001835-0s7ok4uw	4219	9	integration	integration	NN
cord-001835-0s7ok4uw	4219	10	with	with	IN
cord-001835-0s7ok4uw	4219	11	high	high	JJ
cord-001835-0s7ok4uw	4219	12	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4219	13	.	.	.
cord-001835-0s7ok4uw	4220	1	A	a	DT
cord-001835-0s7ok4uw	4220	2	major	major	JJ
cord-001835-0s7ok4uw	4220	3	limitation	limitation	NN
cord-001835-0s7ok4uw	4220	4	of	of	IN
cord-001835-0s7ok4uw	4220	5	this	this	DT
cord-001835-0s7ok4uw	4220	6	approach	approach	NN
cord-001835-0s7ok4uw	4220	7	is	be	VBZ
cord-001835-0s7ok4uw	4220	8	that	that	IN
cord-001835-0s7ok4uw	4220	9	recombinases	recombinase	NNS
cord-001835-0s7ok4uw	4220	10	,	,	,
cord-001835-0s7ok4uw	4220	11	such	such	JJ
cord-001835-0s7ok4uw	4220	12	as	as	IN
cord-001835-0s7ok4uw	4220	13	Cre	Cre	NNP
cord-001835-0s7ok4uw	4220	14	,	,	,
cord-001835-0s7ok4uw	4220	15	natively	natively	RB
cord-001835-0s7ok4uw	4220	16	bind	bind	VBP
cord-001835-0s7ok4uw	4220	17	with	with	IN
cord-001835-0s7ok4uw	4220	18	high	high	JJ
cord-001835-0s7ok4uw	4220	19	specificity	specificity	NN
cord-001835-0s7ok4uw	4220	20	to	to	IN
cord-001835-0s7ok4uw	4220	21	long	long	JJ
cord-001835-0s7ok4uw	4220	22	DNA	dna	NN
cord-001835-0s7ok4uw	4220	23	target	target	NN
cord-001835-0s7ok4uw	4220	24	sequences	sequence	NNS
cord-001835-0s7ok4uw	4221	1	(	(	-LRB-
cord-001835-0s7ok4uw	4221	2	LoxP	LoxP	NNP
cord-001835-0s7ok4uw	4221	3	in	in	IN
cord-001835-0s7ok4uw	4221	4	the	the	DT
cord-001835-0s7ok4uw	4221	5	case	case	NN
cord-001835-0s7ok4uw	4221	6	of	of	IN
cord-001835-0s7ok4uw	4221	7	Cre	Cre	NNP
cord-001835-0s7ok4uw	4221	8	)	)	-RRB-
cord-001835-0s7ok4uw	4221	9	that	that	WDT
cord-001835-0s7ok4uw	4221	10	do	do	VBP
cord-001835-0s7ok4uw	4221	11	not	not	RB
cord-001835-0s7ok4uw	4221	12	exist	exist	VB
cord-001835-0s7ok4uw	4221	13	in	in	IN
cord-001835-0s7ok4uw	4221	14	the	the	DT
cord-001835-0s7ok4uw	4221	15	human	human	JJ
cord-001835-0s7ok4uw	4221	16	genome	genome	NN
cord-001835-0s7ok4uw	4221	17	.	.	.
cord-001835-0s7ok4uw	4222	1	Previous	previous	JJ
cord-001835-0s7ok4uw	4222	2	attempts	attempt	NNS
cord-001835-0s7ok4uw	4222	3	at	at	IN
cord-001835-0s7ok4uw	4222	4	evolving	evolve	VBG
cord-001835-0s7ok4uw	4222	5	Cre	Cre	NNP
cord-001835-0s7ok4uw	4222	6	resulted	result	VBD
cord-001835-0s7ok4uw	4222	7	in	in	IN
cord-001835-0s7ok4uw	4222	8	modest	modest	JJ
cord-001835-0s7ok4uw	4222	9	changes	change	NNS
cord-001835-0s7ok4uw	4222	10	to	to	IN
cord-001835-0s7ok4uw	4222	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4222	12	specificity	specificity	NN
cord-001835-0s7ok4uw	4222	13	,	,	,
cord-001835-0s7ok4uw	4222	14	or	or	CC
cord-001835-0s7ok4uw	4222	15	required	require	VBD
cord-001835-0s7ok4uw	4222	16	hundreds	hundred	NNS
cord-001835-0s7ok4uw	4222	17	of	of	IN
cord-001835-0s7ok4uw	4222	18	rounds	round	NNS
cord-001835-0s7ok4uw	4222	19	of	of	IN
cord-001835-0s7ok4uw	4222	20	manual	manual	JJ
cord-001835-0s7ok4uw	4222	21	protein	protein	NN
cord-001835-0s7ok4uw	4222	22	evolution	evolution	NN
cord-001835-0s7ok4uw	4222	23	.	.	.
cord-001835-0s7ok4uw	4223	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4223	2	developed	develop	VBD
cord-001835-0s7ok4uw	4223	3	and	and	CC
cord-001835-0s7ok4uw	4223	4	validated	validate	VBD
cord-001835-0s7ok4uw	4223	5	a	a	DT
cord-001835-0s7ok4uw	4223	6	Phage	Phage	NNP
cord-001835-0s7ok4uw	4223	7	Assisted	Assisted	NNP
cord-001835-0s7ok4uw	4223	8	Continuous	Continuous	NNP
cord-001835-0s7ok4uw	4223	9	Evoluiton	Evoluiton	NNP
cord-001835-0s7ok4uw	4223	10	(	(	-LRB-
cord-001835-0s7ok4uw	4223	11	PACE	pace	NN
cord-001835-0s7ok4uw	4223	12	)	)	-RRB-
cord-001835-0s7ok4uw	4223	13	selection	selection	NN
cord-001835-0s7ok4uw	4223	14	for	for	IN
cord-001835-0s7ok4uw	4223	15	rapidly	rapidly	RB
cord-001835-0s7ok4uw	4223	16	altering	alter	VBG
cord-001835-0s7ok4uw	4223	17	the	the	DT
cord-001835-0s7ok4uw	4223	18	DNA	dna	NN
cord-001835-0s7ok4uw	4223	19	specificity	specificity	NN
cord-001835-0s7ok4uw	4223	20	of	of	IN
cord-001835-0s7ok4uw	4223	21	Cre	cre	JJ
cord-001835-0s7ok4uw	4223	22	recombinase	recombinase	NN
cord-001835-0s7ok4uw	4223	23	towards	towards	IN
cord-001835-0s7ok4uw	4223	24	a	a	DT
cord-001835-0s7ok4uw	4223	25	site	site	NN
cord-001835-0s7ok4uw	4223	26	present	present	JJ
cord-001835-0s7ok4uw	4223	27	in	in	IN
cord-001835-0s7ok4uw	4223	28	a	a	DT
cord-001835-0s7ok4uw	4223	29	human	human	JJ
cord-001835-0s7ok4uw	4223	30	genomic	genomic	NN
cord-001835-0s7ok4uw	4223	31	safe	safe	JJ
cord-001835-0s7ok4uw	4223	32	harbor	harbor	NN
cord-001835-0s7ok4uw	4223	33	locus	locus	NN
cord-001835-0s7ok4uw	4223	34	.	.	.
cord-001835-0s7ok4uw	4224	1	The	the	DT
cord-001835-0s7ok4uw	4224	2	PACE	pace	NN
cord-001835-0s7ok4uw	4224	3	experiments	experiment	NNS
cord-001835-0s7ok4uw	4224	4	resulted	result	VBD
cord-001835-0s7ok4uw	4224	5	in	in	IN
cord-001835-0s7ok4uw	4224	6	Cre	Cre	NNP
cord-001835-0s7ok4uw	4224	7	variants	variant	NNS
cord-001835-0s7ok4uw	4224	8	capable	capable	JJ
cord-001835-0s7ok4uw	4224	9	of	of	IN
cord-001835-0s7ok4uw	4224	10	recombining	recombine	VBG
cord-001835-0s7ok4uw	4224	11	a	a	DT
cord-001835-0s7ok4uw	4224	12	substrate	substrate	NN
cord-001835-0s7ok4uw	4224	13	with	with	IN
cord-001835-0s7ok4uw	4224	14	nearly	nearly	RB
cord-001835-0s7ok4uw	4224	15	50	50	CD
cord-001835-0s7ok4uw	4224	16	%	%	NN
cord-001835-0s7ok4uw	4224	17	of	of	IN
cord-001835-0s7ok4uw	4224	18	the	the	DT
cord-001835-0s7ok4uw	4224	19	nucleotides	nucleotide	NNS
cord-001835-0s7ok4uw	4224	20	altered	alter	VBN
cord-001835-0s7ok4uw	4224	21	compared	compare	VBN
cord-001835-0s7ok4uw	4224	22	to	to	IN
cord-001835-0s7ok4uw	4224	23	LoxP.	loxp.	NN
cord-001835-0s7ok4uw	4225	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4225	2	successfully	successfully	RB
cord-001835-0s7ok4uw	4225	3	used	use	VBD
cord-001835-0s7ok4uw	4225	4	one	one	CD
cord-001835-0s7ok4uw	4225	5	of	of	IN
cord-001835-0s7ok4uw	4225	6	these	these	DT
cord-001835-0s7ok4uw	4225	7	variants	variant	NNS
cord-001835-0s7ok4uw	4225	8	to	to	TO
cord-001835-0s7ok4uw	4225	9	integrate	integrate	VB
cord-001835-0s7ok4uw	4225	10	exogenous	exogenous	JJ
cord-001835-0s7ok4uw	4225	11	DNA	dna	NN
cord-001835-0s7ok4uw	4225	12	into	into	IN
cord-001835-0s7ok4uw	4225	13	the	the	DT
cord-001835-0s7ok4uw	4225	14	genome	genome	NN
cord-001835-0s7ok4uw	4225	15	of	of	IN
cord-001835-0s7ok4uw	4225	16	unmodified	unmodified	JJ
cord-001835-0s7ok4uw	4225	17	human	human	JJ
cord-001835-0s7ok4uw	4225	18	cells	cell	NNS
cord-001835-0s7ok4uw	4225	19	.	.	.
cord-001835-0s7ok4uw	4226	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4226	2	are	be	VBP
cord-001835-0s7ok4uw	4226	3	currently	currently	RB
cord-001835-0s7ok4uw	4226	4	using	use	VBG
cord-001835-0s7ok4uw	4226	5	sequencing	sequencing	NN
cord-001835-0s7ok4uw	4226	6	methods	method	NNS
cord-001835-0s7ok4uw	4226	7	to	to	TO
cord-001835-0s7ok4uw	4226	8	determine	determine	VB
cord-001835-0s7ok4uw	4226	9	the	the	DT
cord-001835-0s7ok4uw	4226	10	specificity	specificity	NN
cord-001835-0s7ok4uw	4226	11	of	of	IN
cord-001835-0s7ok4uw	4226	12	the	the	DT
cord-001835-0s7ok4uw	4226	13	new	new	JJ
cord-001835-0s7ok4uw	4226	14	recombinase	recombinase	NNP
cord-001835-0s7ok4uw	4226	15	clones	clone	NNS
cord-001835-0s7ok4uw	4226	16	.	.	.
cord-001835-0s7ok4uw	4227	1	Aleardo	Aleardo	NNP
cord-001835-0s7ok4uw	4227	2	Morelli	Morelli	NNP
cord-001835-0s7ok4uw	4227	3	1	1	CD
cord-001835-0s7ok4uw	4227	4	,	,	,
cord-001835-0s7ok4uw	4227	5	Burckhard	Burckhard	NNP
cord-001835-0s7ok4uw	4227	6	Seelig	Seelig	NNP
cord-001835-0s7ok4uw	4227	7	1	1	CD
cord-001835-0s7ok4uw	4227	8	1	1	CD
cord-001835-0s7ok4uw	4227	9	Generation	generation	NN
cord-001835-0s7ok4uw	4227	10	of	of	IN
cord-001835-0s7ok4uw	4227	11	comprehensive	comprehensive	JJ
cord-001835-0s7ok4uw	4227	12	deletion	deletion	NN
cord-001835-0s7ok4uw	4227	13	libraries	library	NNS
cord-001835-0s7ok4uw	4227	14	mediated	mediate	VBN
cord-001835-0s7ok4uw	4227	15	by	by	IN
cord-001835-0s7ok4uw	4227	16	in	in	FW
cord-001835-0s7ok4uw	4227	17	vitro	vitro	FW
cord-001835-0s7ok4uw	4227	18	transposition	transposition	NN
cord-001835-0s7ok4uw	4227	19	Analysis	Analysis	NNP
cord-001835-0s7ok4uw	4227	20	of	of	IN
cord-001835-0s7ok4uw	4227	21	protein	protein	NN
cord-001835-0s7ok4uw	4227	22	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4227	23	and	and	CC
cord-001835-0s7ok4uw	4227	24	ribozymes	ribozyme	NNS
cord-001835-0s7ok4uw	4227	25	from	from	IN
cord-001835-0s7ok4uw	4227	26	nature	nature	NN
cord-001835-0s7ok4uw	4227	27	,	,	,
cord-001835-0s7ok4uw	4227	28	and	and	CC
cord-001835-0s7ok4uw	4227	29	from	from	IN
cord-001835-0s7ok4uw	4227	30	in	in	IN
cord-001835-0s7ok4uw	4227	31	vitro	vitro	FW
cord-001835-0s7ok4uw	4227	32	evolution	evolution	NN
cord-001835-0s7ok4uw	4227	33	,	,	,
cord-001835-0s7ok4uw	4227	34	revealed	reveal	VBD
cord-001835-0s7ok4uw	4227	35	that	that	IN
cord-001835-0s7ok4uw	4227	36	deletions	deletion	NNS
cord-001835-0s7ok4uw	4227	37	of	of	IN
cord-001835-0s7ok4uw	4227	38	up	up	IN
cord-001835-0s7ok4uw	4227	39	to	to	IN
cord-001835-0s7ok4uw	4227	40	dozens	dozen	NNS
cord-001835-0s7ok4uw	4227	41	of	of	IN
cord-001835-0s7ok4uw	4227	42	amino	amino	JJ
cord-001835-0s7ok4uw	4227	43	acids	acid	NNS
cord-001835-0s7ok4uw	4227	44	(	(	-LRB-
cord-001835-0s7ok4uw	4227	45	or	or	CC
cord-001835-0s7ok4uw	4227	46	nucleotides	nucleotide	NNS
cord-001835-0s7ok4uw	4227	47	)	)	-RRB-
cord-001835-0s7ok4uw	4227	48	can	can	MD
cord-001835-0s7ok4uw	4227	49	be	be	VB
cord-001835-0s7ok4uw	4227	50	structurally	structurally	RB
cord-001835-0s7ok4uw	4227	51	tolerated	tolerate	VBN
cord-001835-0s7ok4uw	4227	52	.	.	.
cord-001835-0s7ok4uw	4228	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	4228	2	,	,	,
cord-001835-0s7ok4uw	4228	3	shortened	shorten	VBN
cord-001835-0s7ok4uw	4228	4	variants	variant	NNS
cord-001835-0s7ok4uw	4228	5	can	can	MD
cord-001835-0s7ok4uw	4228	6	exhibit	exhibit	VB
cord-001835-0s7ok4uw	4228	7	better	well	JJR
cord-001835-0s7ok4uw	4228	8	stability	stability	NN
cord-001835-0s7ok4uw	4228	9	and	and	CC
cord-001835-0s7ok4uw	4228	10	increased	increase	VBN
cord-001835-0s7ok4uw	4228	11	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	4228	12	activity	activity	NN
cord-001835-0s7ok4uw	4228	13	.	.	.
cord-001835-0s7ok4uw	4229	1	In	in	IN
cord-001835-0s7ok4uw	4229	2	order	order	NN
cord-001835-0s7ok4uw	4229	3	to	to	TO
cord-001835-0s7ok4uw	4229	4	investigate	investigate	VB
cord-001835-0s7ok4uw	4229	5	the	the	DT
cord-001835-0s7ok4uw	4229	6	effects	effect	NNS
cord-001835-0s7ok4uw	4229	7	of	of	IN
cord-001835-0s7ok4uw	4229	8	deletions	deletion	NNS
cord-001835-0s7ok4uw	4229	9	,	,	,
cord-001835-0s7ok4uw	4229	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	4229	11	developed	develop	VBD
cord-001835-0s7ok4uw	4229	12	a	a	DT
cord-001835-0s7ok4uw	4229	13	new	new	JJ
cord-001835-0s7ok4uw	4229	14	procedure	procedure	NN
cord-001835-0s7ok4uw	4229	15	based	base	VBN
cord-001835-0s7ok4uw	4229	16	on	on	IN
cord-001835-0s7ok4uw	4229	17	in	in	IN
cord-001835-0s7ok4uw	4229	18	vitro	vitro	FW
cord-001835-0s7ok4uw	4229	19	transposition	transposition	NN
cord-001835-0s7ok4uw	4229	20	to	to	TO
cord-001835-0s7ok4uw	4229	21	build	build	VB
cord-001835-0s7ok4uw	4229	22	libraries	library	NNS
cord-001835-0s7ok4uw	4229	23	of	of	IN
cord-001835-0s7ok4uw	4229	24	more	more	JJR
cord-001835-0s7ok4uw	4229	25	than	than	IN
cord-001835-0s7ok4uw	4229	26	10,000	10,000	CD
cord-001835-0s7ok4uw	4229	27	deletion	deletion	NN
cord-001835-0s7ok4uw	4229	28	mutants	mutant	NNS
cord-001835-0s7ok4uw	4229	29	in	in	IN
cord-001835-0s7ok4uw	4229	30	three	three	CD
cord-001835-0s7ok4uw	4229	31	to	to	TO
cord-001835-0s7ok4uw	4229	32	four	four	CD
cord-001835-0s7ok4uw	4229	33	days	day	NNS
cord-001835-0s7ok4uw	4229	34	.	.	.
cord-001835-0s7ok4uw	4230	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4230	2	tested	test	VBD
cord-001835-0s7ok4uw	4230	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4230	4	procedure	procedure	NN
cord-001835-0s7ok4uw	4230	5	on	on	IN
cord-001835-0s7ok4uw	4230	6	DNA	dna	NN
cord-001835-0s7ok4uw	4230	7	sequences	sequence	NNS
cord-001835-0s7ok4uw	4230	8	coding	code	VBG
cord-001835-0s7ok4uw	4230	9	for	for	IN
cord-001835-0s7ok4uw	4230	10	an	an	DT
cord-001835-0s7ok4uw	4230	11	artificial	artificial	JJ
cord-001835-0s7ok4uw	4230	12	RNA	RNA	NNP
cord-001835-0s7ok4uw	4230	13	ligase	ligase	NN
cord-001835-0s7ok4uw	4230	14	called	call	VBN
cord-001835-0s7ok4uw	4230	15	ligase	ligase	NN
cord-001835-0s7ok4uw	4230	16	10C.	10c.	CD
cord-001835-0s7ok4uw	4231	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4231	2	used	use	VBD
cord-001835-0s7ok4uw	4231	3	the	the	DT
cord-001835-0s7ok4uw	4231	4	generated	generate	VBN
cord-001835-0s7ok4uw	4231	5	library	library	NN
cord-001835-0s7ok4uw	4231	6	for	for	IN
cord-001835-0s7ok4uw	4231	7	an	an	DT
cord-001835-0s7ok4uw	4231	8	mRNA	mRNA	NNP
cord-001835-0s7ok4uw	4231	9	display	display	NN
cord-001835-0s7ok4uw	4231	10	selection	selection	NN
cord-001835-0s7ok4uw	4231	11	,	,	,
cord-001835-0s7ok4uw	4231	12	and	and	CC
cord-001835-0s7ok4uw	4231	13	isolated	isolate	VBD
cord-001835-0s7ok4uw	4231	14	two	two	CD
cord-001835-0s7ok4uw	4231	15	active	active	JJ
cord-001835-0s7ok4uw	4231	16	mutants	mutant	NNS
cord-001835-0s7ok4uw	4231	17	containing	contain	VBG
cord-001835-0s7ok4uw	4231	18	18	18	CD
cord-001835-0s7ok4uw	4231	19	and	and	CC
cord-001835-0s7ok4uw	4231	20	13	13	CD
cord-001835-0s7ok4uw	4231	21	amino	amino	JJ
cord-001835-0s7ok4uw	4231	22	acids	acid	NNS
cord-001835-0s7ok4uw	4231	23	N	n	CD
cord-001835-0s7ok4uw	4231	24	-	-	HYPH
cord-001835-0s7ok4uw	4231	25	terminal	terminal	NN
cord-001835-0s7ok4uw	4231	26	deletions	deletion	NNS
cord-001835-0s7ok4uw	4231	27	.	.	.
cord-001835-0s7ok4uw	4232	1	Structural	structural	JJ
cord-001835-0s7ok4uw	4232	2	characterization	characterization	NN
cord-001835-0s7ok4uw	4232	3	of	of	IN
cord-001835-0s7ok4uw	4232	4	PpsC	PpsC	NNP
cord-001835-0s7ok4uw	4232	5	,	,	,
cord-001835-0s7ok4uw	4232	6	a	a	DT
cord-001835-0s7ok4uw	4232	7	multi	multi	JJ
cord-001835-0s7ok4uw	4232	8	-	-	JJ
cord-001835-0s7ok4uw	4232	9	domain	domain	JJ
cord-001835-0s7ok4uw	4232	10	polyketide	polyketide	NN
cord-001835-0s7ok4uw	4232	11	synthase	synthase	NN
cord-001835-0s7ok4uw	4232	12	from	from	IN
cord-001835-0s7ok4uw	4232	13	Mycobacterium	Mycobacterium	NNP
cord-001835-0s7ok4uw	4232	14	tuberculosis	tuberculosis	NN
cord-001835-0s7ok4uw	4232	15	using	use	VBG
cord-001835-0s7ok4uw	4232	16	a	a	DT
cord-001835-0s7ok4uw	4232	17	fragment	fragment	NN
cord-001835-0s7ok4uw	4232	18	-	-	HYPH
cord-001835-0s7ok4uw	4232	19	based	base	VBN
cord-001835-0s7ok4uw	4232	20	approach	approach	NN
cord-001835-0s7ok4uw	4232	21	Alexandre	Alexandre	NNP
cord-001835-0s7ok4uw	4232	22	Faille	Faille	NNP
cord-001835-0s7ok4uw	4232	23	1	1	CD
cord-001835-0s7ok4uw	4232	24	,	,	,
cord-001835-0s7ok4uw	4232	25	Nawel	Nawel	NNP
cord-001835-0s7ok4uw	4232	26	Slama1	Slama1	NNP
cord-001835-0s7ok4uw	4232	27	1	1	CD
cord-001835-0s7ok4uw	4232	28	,	,	,
cord-001835-0s7ok4uw	4232	29	Anna	Anna	NNP
cord-001835-0s7ok4uw	4232	30	Grabowska	Grabowska	NNP
cord-001835-0s7ok4uw	4232	31	1	1	CD
cord-001835-0s7ok4uw	4232	32	,	,	,
cord-001835-0s7ok4uw	4232	33	David	David	NNP
cord-001835-0s7ok4uw	4232	34	Ricard	Ricard	NNP
cord-001835-0s7ok4uw	4232	35	1	1	CD
cord-001835-0s7ok4uw	4232	36	,	,	,
cord-001835-0s7ok4uw	4232	37	Annaik	Annaik	NNP
cord-001835-0s7ok4uw	4232	38	Qu	Qu	NNP
cord-001835-0s7ok4uw	4232	39	emard	emard	NN
cord-001835-0s7ok4uw	4232	40	1	1	CD
cord-001835-0s7ok4uw	4232	41	,	,	,
cord-001835-0s7ok4uw	4232	42	Lionel	Lionel	NNP
cord-001835-0s7ok4uw	4232	43	Mourey	Mourey	NNP
cord-001835-0s7ok4uw	4232	44	1	1	CD
cord-001835-0s7ok4uw	4232	45	,	,	,
cord-001835-0s7ok4uw	4232	46	Jean	Jean	NNP
cord-001835-0s7ok4uw	4232	47	-	-	HYPH
cord-001835-0s7ok4uw	4232	48	Denis	Denis	NNP
cord-001835-0s7ok4uw	4232	49	Pedelacq	Pedelacq	NNP
cord-001835-0s7ok4uw	4232	50	1	1	CD
cord-001835-0s7ok4uw	4232	51	1	1	CD
cord-001835-0s7ok4uw	4232	52	Polyketide	Polyketide	NNP
cord-001835-0s7ok4uw	4232	53	synthases	synthase	NNS
cord-001835-0s7ok4uw	4232	54	are	be	VBP
cord-001835-0s7ok4uw	4232	55	of	of	IN
cord-001835-0s7ok4uw	4232	56	great	great	JJ
cord-001835-0s7ok4uw	4232	57	interest	interest	NN
cord-001835-0s7ok4uw	4232	58	in	in	IN
cord-001835-0s7ok4uw	4232	59	numerous	numerous	JJ
cord-001835-0s7ok4uw	4232	60	scientific	scientific	JJ
cord-001835-0s7ok4uw	4232	61	fields	field	NNS
cord-001835-0s7ok4uw	4232	62	.	.	.
cord-001835-0s7ok4uw	4233	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	4233	2	are	be	VBP
cord-001835-0s7ok4uw	4233	3	composed	compose	VBN
cord-001835-0s7ok4uw	4233	4	by	by	IN
cord-001835-0s7ok4uw	4233	5	multiple	multiple	JJ
cord-001835-0s7ok4uw	4233	6	domains	domain	NNS
cord-001835-0s7ok4uw	4233	7	,	,	,
cord-001835-0s7ok4uw	4233	8	each	each	DT
cord-001835-0s7ok4uw	4233	9	having	have	VBG
cord-001835-0s7ok4uw	4233	10	a	a	DT
cord-001835-0s7ok4uw	4233	11	different	different	JJ
cord-001835-0s7ok4uw	4233	12	role	role	NN
cord-001835-0s7ok4uw	4233	13	to	to	TO
cord-001835-0s7ok4uw	4233	14	play	play	VB
cord-001835-0s7ok4uw	4233	15	in	in	IN
cord-001835-0s7ok4uw	4233	16	the	the	DT
cord-001835-0s7ok4uw	4233	17	catalysis	catalysis	NN
cord-001835-0s7ok4uw	4233	18	of	of	IN
cord-001835-0s7ok4uw	4233	19	sequential	sequential	JJ
cord-001835-0s7ok4uw	4233	20	reactions	reaction	NNS
cord-001835-0s7ok4uw	4233	21	including	include	VBG
cord-001835-0s7ok4uw	4233	22	condensation	condensation	NN
cord-001835-0s7ok4uw	4233	23	,	,	,
cord-001835-0s7ok4uw	4233	24	reduction	reduction	NN
cord-001835-0s7ok4uw	4233	25	and	and	CC
cord-001835-0s7ok4uw	4233	26	esterification	esterification	NN
cord-001835-0s7ok4uw	4233	27	.	.	.
cord-001835-0s7ok4uw	4234	1	Their	-PRON-	PRP$
cord-001835-0s7ok4uw	4234	2	reaction	reaction	NN
cord-001835-0s7ok4uw	4234	3	products	product	NNS
cord-001835-0s7ok4uw	4234	4	,	,	,
cord-001835-0s7ok4uw	4234	5	named	name	VBN
cord-001835-0s7ok4uw	4234	6	polyketides	polyketides	NNP
cord-001835-0s7ok4uw	4234	7	,	,	,
cord-001835-0s7ok4uw	4234	8	represent	represent	VBP
cord-001835-0s7ok4uw	4234	9	a	a	DT
cord-001835-0s7ok4uw	4234	10	large	large	JJ
cord-001835-0s7ok4uw	4234	11	variety	variety	NN
cord-001835-0s7ok4uw	4234	12	of	of	IN
cord-001835-0s7ok4uw	4234	13	chemical	chemical	JJ
cord-001835-0s7ok4uw	4234	14	compounds	compound	NNS
cord-001835-0s7ok4uw	4234	15	,	,	,
cord-001835-0s7ok4uw	4234	16	from	from	IN
cord-001835-0s7ok4uw	4234	17	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	4234	18	to	to	IN
cord-001835-0s7ok4uw	4234	19	immunosuppressors	immunosuppressor	NNS
cord-001835-0s7ok4uw	4234	20	or	or	CC
cord-001835-0s7ok4uw	4234	21	even	even	RB
cord-001835-0s7ok4uw	4234	22	anticancer	anticancer	JJ
cord-001835-0s7ok4uw	4234	23	drugs	drug	NNS
cord-001835-0s7ok4uw	4234	24	.	.	.
cord-001835-0s7ok4uw	4235	1	PpsC	PpsC	NNP
cord-001835-0s7ok4uw	4235	2	is	be	VBZ
cord-001835-0s7ok4uw	4235	3	a	a	DT
cord-001835-0s7ok4uw	4235	4	231	231	CD
cord-001835-0s7ok4uw	4235	5	KDa	KDa	NNS
cord-001835-0s7ok4uw	4235	6	polyketide	polyketide	NN
cord-001835-0s7ok4uw	4235	7	synthase	synthase	NN
cord-001835-0s7ok4uw	4235	8	,	,	,
cord-001835-0s7ok4uw	4235	9	organised	organise	VBN
cord-001835-0s7ok4uw	4235	10	into	into	IN
cord-001835-0s7ok4uw	4235	11	six	six	CD
cord-001835-0s7ok4uw	4235	12	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	4235	13	domains	domain	NNS
cord-001835-0s7ok4uw	4235	14	(	(	-LRB-
cord-001835-0s7ok4uw	4235	15	KS	KS	NNP
cord-001835-0s7ok4uw	4235	16	-	-	HYPH
cord-001835-0s7ok4uw	4235	17	AT	AT	NNP
cord-001835-0s7ok4uw	4235	18	-	-	HYPH
cord-001835-0s7ok4uw	4235	19	DH	dh	NN
cord-001835-0s7ok4uw	4235	20	-	-	HYPH
cord-001835-0s7ok4uw	4235	21	ER	ER	NNP
cord-001835-0s7ok4uw	4235	22	-	-	HYPH
cord-001835-0s7ok4uw	4235	23	KR	KR	NNP
cord-001835-0s7ok4uw	4235	24	-	-	HYPH
cord-001835-0s7ok4uw	4235	25	ACP	ACP	NNP
cord-001835-0s7ok4uw	4235	26	)	)	-RRB-
cord-001835-0s7ok4uw	4235	27	with	with	IN
cord-001835-0s7ok4uw	4235	28	singular	singular	JJ
cord-001835-0s7ok4uw	4235	29	functions	function	NNS
cord-001835-0s7ok4uw	4235	30	.	.	.
cord-001835-0s7ok4uw	4236	1	Along	along	IN
cord-001835-0s7ok4uw	4236	2	with	with	IN
cord-001835-0s7ok4uw	4236	3	other	other	JJ
cord-001835-0s7ok4uw	4236	4	type	type	NN
cord-001835-0s7ok4uw	4236	5	I	-PRON-	PRP
cord-001835-0s7ok4uw	4236	6	polyketide	polyketide	NN
cord-001835-0s7ok4uw	4236	7	synthases	synthase	NNS
cord-001835-0s7ok4uw	4236	8	,	,	,
cord-001835-0s7ok4uw	4236	9	PpsC	PpsC	NNP
cord-001835-0s7ok4uw	4236	10	is	be	VBZ
cord-001835-0s7ok4uw	4236	11	responsible	responsible	JJ
cord-001835-0s7ok4uw	4236	12	for	for	IN
cord-001835-0s7ok4uw	4236	13	the	the	DT
cord-001835-0s7ok4uw	4236	14	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	4236	15	of	of	IN
cord-001835-0s7ok4uw	4236	16	an	an	DT
cord-001835-0s7ok4uw	4236	17	essential	essential	JJ
cord-001835-0s7ok4uw	4236	18	polyketide	polyketide	NN
cord-001835-0s7ok4uw	4236	19	for	for	IN
cord-001835-0s7ok4uw	4236	20	the	the	DT
cord-001835-0s7ok4uw	4236	21	virulence	virulence	NN
cord-001835-0s7ok4uw	4236	22	of	of	IN
cord-001835-0s7ok4uw	4236	23	Mycobacterium	Mycobacterium	NNP
cord-001835-0s7ok4uw	4236	24	tuberculosis	tuberculosis	NN
cord-001835-0s7ok4uw	4236	25	(	(	-LRB-
cord-001835-0s7ok4uw	4236	26	Mtb	Mtb	NNP
cord-001835-0s7ok4uw	4236	27	)	)	-RRB-
cord-001835-0s7ok4uw	4236	28	and	and	CC
cord-001835-0s7ok4uw	4236	29	thus	thus	RB
cord-001835-0s7ok4uw	4236	30	is	be	VBZ
cord-001835-0s7ok4uw	4236	31	a	a	DT
cord-001835-0s7ok4uw	4236	32	target	target	NN
cord-001835-0s7ok4uw	4236	33	of	of	IN
cord-001835-0s7ok4uw	4236	34	choice	choice	NN
cord-001835-0s7ok4uw	4236	35	for	for	IN
cord-001835-0s7ok4uw	4236	36	the	the	DT
cord-001835-0s7ok4uw	4236	37	design	design	NN
cord-001835-0s7ok4uw	4236	38	of	of	IN
cord-001835-0s7ok4uw	4236	39	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4236	40	.	.	.
cord-001835-0s7ok4uw	4237	1	To	to	IN
cord-001835-0s7ok4uw	4237	2	date	date	NN
cord-001835-0s7ok4uw	4237	3	,	,	,
cord-001835-0s7ok4uw	4237	4	no	no	DT
cord-001835-0s7ok4uw	4237	5	structural	structural	JJ
cord-001835-0s7ok4uw	4237	6	information	information	NN
cord-001835-0s7ok4uw	4237	7	of	of	IN
cord-001835-0s7ok4uw	4237	8	any	any	DT
cord-001835-0s7ok4uw	4237	9	type	type	NN
cord-001835-0s7ok4uw	4237	10	I	-PRON-	PRP
cord-001835-0s7ok4uw	4237	11	Polyketide	Polyketide	NNP
cord-001835-0s7ok4uw	4237	12	synthase	synthase	NN
cord-001835-0s7ok4uw	4237	13	in	in	IN
cord-001835-0s7ok4uw	4237	14	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4237	15	entire	entire	JJ
cord-001835-0s7ok4uw	4237	16	form	form	NN
cord-001835-0s7ok4uw	4237	17	has	have	VBZ
cord-001835-0s7ok4uw	4237	18	been	be	VBN
cord-001835-0s7ok4uw	4237	19	described	describe	VBN
cord-001835-0s7ok4uw	4237	20	.	.	.
cord-001835-0s7ok4uw	4238	1	Main	main	JJ
cord-001835-0s7ok4uw	4238	2	reasons	reason	NNS
cord-001835-0s7ok4uw	4238	3	are	be	VBP
cord-001835-0s7ok4uw	4238	4	the	the	DT
cord-001835-0s7ok4uw	4238	5	length	length	NN
cord-001835-0s7ok4uw	4238	6	of	of	IN
cord-001835-0s7ok4uw	4238	7	these	these	DT
cord-001835-0s7ok4uw	4238	8	large	large	JJ
cord-001835-0s7ok4uw	4238	9	size	size	NN
cord-001835-0s7ok4uw	4238	10	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4238	11	and	and	CC
cord-001835-0s7ok4uw	4238	12	the	the	DT
cord-001835-0s7ok4uw	4238	13	flexibility	flexibility	NN
cord-001835-0s7ok4uw	4238	14	imposed	impose	VBN
cord-001835-0s7ok4uw	4238	15	by	by	IN
cord-001835-0s7ok4uw	4238	16	the	the	DT
cord-001835-0s7ok4uw	4238	17	linkers	linker	NNS
cord-001835-0s7ok4uw	4238	18	between	between	IN
cord-001835-0s7ok4uw	4238	19	domains	domain	NNS
cord-001835-0s7ok4uw	4238	20	,	,	,
cord-001835-0s7ok4uw	4238	21	thus	thus	RB
cord-001835-0s7ok4uw	4238	22	making	make	VBG
cord-001835-0s7ok4uw	4238	23	them	-PRON-	PRP
cord-001835-0s7ok4uw	4238	24	very	very	RB
cord-001835-0s7ok4uw	4238	25	difficult	difficult	JJ
cord-001835-0s7ok4uw	4238	26	to	to	TO
cord-001835-0s7ok4uw	4238	27	crystallize	crystallize	VB
cord-001835-0s7ok4uw	4238	28	.	.	.
cord-001835-0s7ok4uw	4239	1	Numerous	numerous	JJ
cord-001835-0s7ok4uw	4239	2	questions	question	NNS
cord-001835-0s7ok4uw	4239	3	about	about	IN
cord-001835-0s7ok4uw	4239	4	domain	domain	NN
cord-001835-0s7ok4uw	4239	5	-	-	HYPH
cord-001835-0s7ok4uw	4239	6	domain	domain	NN
cord-001835-0s7ok4uw	4239	7	interactions	interaction	NNS
cord-001835-0s7ok4uw	4239	8	,	,	,
cord-001835-0s7ok4uw	4239	9	spatial	spatial	JJ
cord-001835-0s7ok4uw	4239	10	arrangement	arrangement	NN
cord-001835-0s7ok4uw	4239	11	of	of	IN
cord-001835-0s7ok4uw	4239	12	this	this	DT
cord-001835-0s7ok4uw	4239	13	complex	complex	JJ
cord-001835-0s7ok4uw	4239	14	machinery	machinery	NN
cord-001835-0s7ok4uw	4239	15	,	,	,
cord-001835-0s7ok4uw	4239	16	substrate	substrate	NN
cord-001835-0s7ok4uw	4239	17	specificity	specificity	NN
cord-001835-0s7ok4uw	4239	18	and	and	CC
cord-001835-0s7ok4uw	4239	19	stereochemistry	stereochemistry	NN
cord-001835-0s7ok4uw	4239	20	are	be	VBP
cord-001835-0s7ok4uw	4239	21	still	still	RB
cord-001835-0s7ok4uw	4239	22	unanswered	unanswered	JJ
cord-001835-0s7ok4uw	4239	23	.	.	.
cord-001835-0s7ok4uw	4240	1	Addressing	address	VBG
cord-001835-0s7ok4uw	4240	2	the	the	DT
cord-001835-0s7ok4uw	4240	3	structural	structural	JJ
cord-001835-0s7ok4uw	4240	4	and	and	CC
cord-001835-0s7ok4uw	4240	5	functional	functional	JJ
cord-001835-0s7ok4uw	4240	6	characterization	characterization	NN
cord-001835-0s7ok4uw	4240	7	of	of	IN
cord-001835-0s7ok4uw	4240	8	PpsC	PpsC	NNP
cord-001835-0s7ok4uw	4240	9	would	would	MD
cord-001835-0s7ok4uw	4240	10	then	then	RB
cord-001835-0s7ok4uw	4240	11	help	help	VB
cord-001835-0s7ok4uw	4240	12	answering	answer	VBG
cord-001835-0s7ok4uw	4240	13	these	these	DT
cord-001835-0s7ok4uw	4240	14	questions	question	NNS
cord-001835-0s7ok4uw	4240	15	and	and	CC
cord-001835-0s7ok4uw	4240	16	provide	provide	VB
cord-001835-0s7ok4uw	4240	17	valuable	valuable	JJ
cord-001835-0s7ok4uw	4240	18	information	information	NN
cord-001835-0s7ok4uw	4240	19	for	for	IN
cord-001835-0s7ok4uw	4240	20	drug	drug	NN
cord-001835-0s7ok4uw	4240	21	design	design	NN
cord-001835-0s7ok4uw	4240	22	.	.	.
cord-001835-0s7ok4uw	4241	1	To	to	TO
cord-001835-0s7ok4uw	4241	2	overcome	overcome	VB
cord-001835-0s7ok4uw	4241	3	the	the	DT
cord-001835-0s7ok4uw	4241	4	length	length	NN
cord-001835-0s7ok4uw	4241	5	-	-	HYPH
cord-001835-0s7ok4uw	4241	6	and	and	CC
cord-001835-0s7ok4uw	4241	7	flexible	flexible	JJ
cord-001835-0s7ok4uw	4241	8	-	-	HYPH
cord-001835-0s7ok4uw	4241	9	dependent	dependent	JJ
cord-001835-0s7ok4uw	4241	10	problem	problem	NN
cord-001835-0s7ok4uw	4241	11	originating	originate	VBG
cord-001835-0s7ok4uw	4241	12	from	from	IN
cord-001835-0s7ok4uw	4241	13	the	the	DT
cord-001835-0s7ok4uw	4241	14	presence	presence	NN
cord-001835-0s7ok4uw	4241	15	of	of	IN
cord-001835-0s7ok4uw	4241	16	multiple	multiple	JJ
cord-001835-0s7ok4uw	4241	17	domains	domain	NNS
cord-001835-0s7ok4uw	4241	18	and	and	CC
cord-001835-0s7ok4uw	4241	19	linkers	linker	NNS
cord-001835-0s7ok4uw	4241	20	,	,	,
cord-001835-0s7ok4uw	4241	21	we	-PRON-	PRP
cord-001835-0s7ok4uw	4241	22	decided	decide	VBD
cord-001835-0s7ok4uw	4241	23	to	to	TO
cord-001835-0s7ok4uw	4241	24	study	study	VB
cord-001835-0s7ok4uw	4241	25	domains	domain	NNS
cord-001835-0s7ok4uw	4241	26	expressed	express	VBN
cord-001835-0s7ok4uw	4241	27	alone	alone	RB
cord-001835-0s7ok4uw	4241	28	.	.	.
cord-001835-0s7ok4uw	4242	1	For	for	IN
cord-001835-0s7ok4uw	4242	2	this	this	DT
cord-001835-0s7ok4uw	4242	3	purpose	purpose	NN
cord-001835-0s7ok4uw	4242	4	,	,	,
cord-001835-0s7ok4uw	4242	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4242	6	used	use	VBD
cord-001835-0s7ok4uw	4242	7	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4242	8	domain	domain	NN
cord-001835-0s7ok4uw	4242	9	trapping	trap	VBG
cord-001835-0s7ok4uw	4242	10	strategy	strategy	NN
cord-001835-0s7ok4uw	4242	11	to	to	TO
cord-001835-0s7ok4uw	4242	12	identify	identify	VB
cord-001835-0s7ok4uw	4242	13	soluble	soluble	JJ
cord-001835-0s7ok4uw	4242	14	fragments	fragment	NNS
cord-001835-0s7ok4uw	4242	15	representing	represent	VBG
cord-001835-0s7ok4uw	4242	16	a	a	DT
cord-001835-0s7ok4uw	4242	17	single	single	JJ
cord-001835-0s7ok4uw	4242	18	domain	domain	NN
cord-001835-0s7ok4uw	4242	19	from	from	IN
cord-001835-0s7ok4uw	4242	20	PpsC	ppsc	NN
cord-001835-0s7ok4uw	4242	21	[	[	-LRB-
cord-001835-0s7ok4uw	4242	22	1	1	CD
cord-001835-0s7ok4uw	4242	23	]	]	-RRB-
cord-001835-0s7ok4uw	4242	24	.	.	.
cord-001835-0s7ok4uw	4243	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4243	2	has	have	VBZ
cord-001835-0s7ok4uw	4243	3	the	the	DT
cord-001835-0s7ok4uw	4243	4	advantage	advantage	NN
cord-001835-0s7ok4uw	4243	5	of	of	IN
cord-001835-0s7ok4uw	4243	6	not	not	RB
cord-001835-0s7ok4uw	4243	7	relying	rely	VBG
cord-001835-0s7ok4uw	4243	8	on	on	IN
cord-001835-0s7ok4uw	4243	9	the	the	DT
cord-001835-0s7ok4uw	4243	10	bioinformatically	bioinformatically	RB
cord-001835-0s7ok4uw	4243	11	designed	design	VBN
cord-001835-0s7ok4uw	4243	12	domain	domain	NN
cord-001835-0s7ok4uw	4243	13	boundaries	boundary	NNS
cord-001835-0s7ok4uw	4243	14	and	and	CC
cord-001835-0s7ok4uw	4243	15	can	can	MD
cord-001835-0s7ok4uw	4243	16	even	even	RB
cord-001835-0s7ok4uw	4243	17	sometimes	sometimes	RB
cord-001835-0s7ok4uw	4243	18	include	include	VBP
cord-001835-0s7ok4uw	4243	19	parts	part	NNS
cord-001835-0s7ok4uw	4243	20	of	of	IN
cord-001835-0s7ok4uw	4243	21	linkers	linker	NNS
cord-001835-0s7ok4uw	4243	22	to	to	TO
cord-001835-0s7ok4uw	4243	23	obtain	obtain	VB
cord-001835-0s7ok4uw	4243	24	more	more	RBR
cord-001835-0s7ok4uw	4243	25	soluble	soluble	JJ
cord-001835-0s7ok4uw	4243	26	fragments	fragment	NNS
cord-001835-0s7ok4uw	4243	27	.	.	.
cord-001835-0s7ok4uw	4244	1	Using	use	VBG
cord-001835-0s7ok4uw	4244	2	this	this	DT
cord-001835-0s7ok4uw	4244	3	strategy	strategy	NN
cord-001835-0s7ok4uw	4244	4	,	,	,
cord-001835-0s7ok4uw	4244	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4244	6	were	be	VBD
cord-001835-0s7ok4uw	4244	7	able	able	JJ
cord-001835-0s7ok4uw	4244	8	to	to	TO
cord-001835-0s7ok4uw	4244	9	identify	identify	VB
cord-001835-0s7ok4uw	4244	10	relatively	relatively	RB
cord-001835-0s7ok4uw	4244	11	small	small	JJ
cord-001835-0s7ok4uw	4244	12	and	and	CC
cord-001835-0s7ok4uw	4244	13	highly	highly	RB
cord-001835-0s7ok4uw	4244	14	soluble	soluble	JJ
cord-001835-0s7ok4uw	4244	15	fragments	fragment	NNS
cord-001835-0s7ok4uw	4244	16	representing	represent	VBG
cord-001835-0s7ok4uw	4244	17	each	each	DT
cord-001835-0s7ok4uw	4244	18	domain	domain	NN
cord-001835-0s7ok4uw	4244	19	of	of	IN
cord-001835-0s7ok4uw	4244	20	PpsC	ppsc	NN
cord-001835-0s7ok4uw	4244	21	,	,	,
cord-001835-0s7ok4uw	4244	22	thus	thus	RB
cord-001835-0s7ok4uw	4244	23	facilitating	facilitate	VBG
cord-001835-0s7ok4uw	4244	24	the	the	DT
cord-001835-0s7ok4uw	4244	25	downstream	downstream	JJ
cord-001835-0s7ok4uw	4244	26	structural	structural	JJ
cord-001835-0s7ok4uw	4244	27	and	and	CC
cord-001835-0s7ok4uw	4244	28	functional	functional	JJ
cord-001835-0s7ok4uw	4244	29	characterization	characterization	NN
cord-001835-0s7ok4uw	4244	30	.	.	.
cord-001835-0s7ok4uw	4245	1	More	More	JJR
cord-001835-0s7ok4uw	4245	2	than	than	IN
cord-001835-0s7ok4uw	4245	3	20	20	CD
cord-001835-0s7ok4uw	4245	4	fragments	fragment	NNS
cord-001835-0s7ok4uw	4245	5	have	have	VBP
cord-001835-0s7ok4uw	4245	6	been	be	VBN
cord-001835-0s7ok4uw	4245	7	submitted	submit	VBN
cord-001835-0s7ok4uw	4245	8	to	to	IN
cord-001835-0s7ok4uw	4245	9	crystallization	crystallization	NN
cord-001835-0s7ok4uw	4245	10	trials	trial	NNS
cord-001835-0s7ok4uw	4245	11	.	.	.
cord-001835-0s7ok4uw	4246	1	Among	among	IN
cord-001835-0s7ok4uw	4246	2	these	these	DT
cord-001835-0s7ok4uw	4246	3	,	,	,
cord-001835-0s7ok4uw	4246	4	5	5	CD
cord-001835-0s7ok4uw	4246	5	gave	give	VBD
cord-001835-0s7ok4uw	4246	6	crystals	crystal	NNS
cord-001835-0s7ok4uw	4246	7	and	and	CC
cord-001835-0s7ok4uw	4246	8	allowed	allow	VBD
cord-001835-0s7ok4uw	4246	9	us	-PRON-	PRP
cord-001835-0s7ok4uw	4246	10	to	to	TO
cord-001835-0s7ok4uw	4246	11	determine	determine	VB
cord-001835-0s7ok4uw	4246	12	the	the	DT
cord-001835-0s7ok4uw	4246	13	X	x	NN
cord-001835-0s7ok4uw	4246	14	-	-	NN
cord-001835-0s7ok4uw	4246	15	ray	ray	JJ
cord-001835-0s7ok4uw	4246	16	structure	structure	NN
cord-001835-0s7ok4uw	4246	17	of	of	IN
cord-001835-0s7ok4uw	4246	18	PpsC	PpsC	NNP
cord-001835-0s7ok4uw	4246	19	AT	AT	NNP
cord-001835-0s7ok4uw	4246	20	,	,	,
cord-001835-0s7ok4uw	4246	21	ER	ER	NNP
cord-001835-0s7ok4uw	4246	22	,	,	,
cord-001835-0s7ok4uw	4246	23	in	in	IN
cord-001835-0s7ok4uw	4246	24	addition	addition	NN
cord-001835-0s7ok4uw	4246	25	to	to	IN
cord-001835-0s7ok4uw	4246	26	the	the	DT
cord-001835-0s7ok4uw	4246	27	DH	DH	NNP
cord-001835-0s7ok4uw	4246	28	domain	domain	NN
cord-001835-0s7ok4uw	4246	29	in	in	IN
cord-001835-0s7ok4uw	4246	30	complex	complex	NN
cord-001835-0s7ok4uw	4246	31	with	with	IN
cord-001835-0s7ok4uw	4246	32	a	a	DT
cord-001835-0s7ok4uw	4246	33	substrate	substrate	JJ
cord-001835-0s7ok4uw	4246	34	analog	analog	NN
cord-001835-0s7ok4uw	4246	35	for	for	IN
cord-001835-0s7ok4uw	4246	36	which	which	WDT
cord-001835-0s7ok4uw	4246	37	activity	activity	NN
cord-001835-0s7ok4uw	4246	38	was	be	VBD
cord-001835-0s7ok4uw	4246	39	confirmed	confirm	VBN
cord-001835-0s7ok4uw	4246	40	in	in	IN
cord-001835-0s7ok4uw	4246	41	vitro	vitro	FW
cord-001835-0s7ok4uw	4246	42	.	.	.
cord-001835-0s7ok4uw	4247	1	The	the	DT
cord-001835-0s7ok4uw	4247	2	computational	computational	JJ
cord-001835-0s7ok4uw	4247	3	design	design	NN
cord-001835-0s7ok4uw	4247	4	of	of	IN
cord-001835-0s7ok4uw	4247	5	proteins	protein	NNS
cord-001835-0s7ok4uw	4247	6	that	that	WDT
cord-001835-0s7ok4uw	4247	7	bind	bind	VBP
cord-001835-0s7ok4uw	4247	8	small	small	JJ
cord-001835-0s7ok4uw	4247	9	molecules	molecule	NNS
cord-001835-0s7ok4uw	4247	10	remains	remain	VBZ
cord-001835-0s7ok4uw	4247	11	a	a	DT
cord-001835-0s7ok4uw	4247	12	difficult	difficult	JJ
cord-001835-0s7ok4uw	4247	13	challenge	challenge	NN
cord-001835-0s7ok4uw	4247	14	in	in	IN
cord-001835-0s7ok4uw	4247	15	protein	protein	NN
cord-001835-0s7ok4uw	4247	16	engineering	engineering	NN
cord-001835-0s7ok4uw	4247	17	.	.	.
cord-001835-0s7ok4uw	4248	1	The	the	DT
cord-001835-0s7ok4uw	4248	2	ability	ability	NN
cord-001835-0s7ok4uw	4248	3	to	to	TO
cord-001835-0s7ok4uw	4248	4	computationally	computationally	RB
cord-001835-0s7ok4uw	4248	5	design	design	VB
cord-001835-0s7ok4uw	4248	6	native	native	JJ
cord-001835-0s7ok4uw	4248	7	-	-	HYPH
cord-001835-0s7ok4uw	4248	8	like	like	JJ
cord-001835-0s7ok4uw	4248	9	interactions	interaction	NNS
cord-001835-0s7ok4uw	4248	10	with	with	IN
cord-001835-0s7ok4uw	4248	11	high	high	JJ
cord-001835-0s7ok4uw	4248	12	accuracy	accuracy	NN
cord-001835-0s7ok4uw	4248	13	and	and	CC
cord-001835-0s7ok4uw	4248	14	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4248	15	would	would	MD
cord-001835-0s7ok4uw	4248	16	be	be	VB
cord-001835-0s7ok4uw	4248	17	an	an	DT
cord-001835-0s7ok4uw	4248	18	asset	asset	NN
cord-001835-0s7ok4uw	4248	19	towards	towards	IN
cord-001835-0s7ok4uw	4248	20	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	4248	21	development	development	NN
cord-001835-0s7ok4uw	4248	22	,	,	,
cord-001835-0s7ok4uw	4248	23	enzyme	enzyme	NN
cord-001835-0s7ok4uw	4248	24	design	design	NN
cord-001835-0s7ok4uw	4248	25	,	,	,
cord-001835-0s7ok4uw	4248	26	and	and	CC
cord-001835-0s7ok4uw	4248	27	engineering	engineer	VBG
cord-001835-0s7ok4uw	4248	28	functional	functional	JJ
cord-001835-0s7ok4uw	4248	29	proteins	protein	NNS
cord-001835-0s7ok4uw	4248	30	.	.	.
cord-001835-0s7ok4uw	4249	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4249	2	have	have	VBP
cord-001835-0s7ok4uw	4249	3	developed	develop	VBN
cord-001835-0s7ok4uw	4249	4	a	a	DT
cord-001835-0s7ok4uw	4249	5	systematic	systematic	JJ
cord-001835-0s7ok4uw	4249	6	approach	approach	NN
cord-001835-0s7ok4uw	4249	7	to	to	IN
cord-001835-0s7ok4uw	4249	8	designing	design	VBG
cord-001835-0s7ok4uw	4249	9	interfaces	interface	NNS
cord-001835-0s7ok4uw	4249	10	.	.	.
cord-001835-0s7ok4uw	4250	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4250	2	first	first	RB
cord-001835-0s7ok4uw	4250	3	identify	identify	VBP
cord-001835-0s7ok4uw	4250	4	ligands	ligand	NNS
cord-001835-0s7ok4uw	4250	5	with	with	IN
cord-001835-0s7ok4uw	4250	6	naive	naive	JJ
cord-001835-0s7ok4uw	4250	7	binding	bind	VBG
cord-001835-0s7ok4uw	4250	8	affinity	affinity	NN
cord-001835-0s7ok4uw	4250	9	to	to	IN
cord-001835-0s7ok4uw	4250	10	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4250	11	protein	protein	NN
cord-001835-0s7ok4uw	4250	12	scaffold	scaffold	NN
cord-001835-0s7ok4uw	4250	13	,	,	,
cord-001835-0s7ok4uw	4250	14	then	then	RB
cord-001835-0s7ok4uw	4250	15	use	use	VB
cord-001835-0s7ok4uw	4250	16	RosettaLigand	RosettaLigand	NNP
cord-001835-0s7ok4uw	4250	17	to	to	TO
cord-001835-0s7ok4uw	4250	18	computationally	computationally	RB
cord-001835-0s7ok4uw	4250	19	dock	dock	VB
cord-001835-0s7ok4uw	4250	20	the	the	DT
cord-001835-0s7ok4uw	4250	21	ligand	ligand	NN
cord-001835-0s7ok4uw	4250	22	while	while	IN
cord-001835-0s7ok4uw	4250	23	designing	design	VBG
cord-001835-0s7ok4uw	4250	24	the	the	DT
cord-001835-0s7ok4uw	4250	25	interface	interface	NN
cord-001835-0s7ok4uw	4250	26	for	for	IN
cord-001835-0s7ok4uw	4250	27	a	a	DT
cord-001835-0s7ok4uw	4250	28	tighter	tight	JJR
cord-001835-0s7ok4uw	4250	29	interaction	interaction	NN
cord-001835-0s7ok4uw	4250	30	.	.	.
cord-001835-0s7ok4uw	4251	1	This	this	DT
cord-001835-0s7ok4uw	4251	2	way	way	NN
cord-001835-0s7ok4uw	4251	3	,	,	,
cord-001835-0s7ok4uw	4251	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	4251	5	are	be	VBP
cord-001835-0s7ok4uw	4251	6	taking	take	VBG
cord-001835-0s7ok4uw	4251	7	a	a	DT
cord-001835-0s7ok4uw	4251	8	'	'	``
cord-001835-0s7ok4uw	4251	9	shot	shot	NN
cord-001835-0s7ok4uw	4251	10	in	in	IN
cord-001835-0s7ok4uw	4251	11	dim	dim	JJ
cord-001835-0s7ok4uw	4251	12	light	light	NN
cord-001835-0s7ok4uw	4251	13	'	'	''
cord-001835-0s7ok4uw	4251	14	for	for	IN
cord-001835-0s7ok4uw	4251	15	design	design	NN
cord-001835-0s7ok4uw	4251	16	as	as	IN
cord-001835-0s7ok4uw	4251	17	opposed	oppose	VBN
cord-001835-0s7ok4uw	4251	18	to	to	IN
cord-001835-0s7ok4uw	4251	19	a	a	DT
cord-001835-0s7ok4uw	4251	20	'	'	``
cord-001835-0s7ok4uw	4251	21	shot	shot	NN
cord-001835-0s7ok4uw	4251	22	in	in	IN
cord-001835-0s7ok4uw	4251	23	the	the	DT
cord-001835-0s7ok4uw	4251	24	dark	dark	NN
cord-001835-0s7ok4uw	4251	25	'	'	''
cord-001835-0s7ok4uw	4251	26	,	,	,
cord-001835-0s7ok4uw	4251	27	allowing	allow	VBG
cord-001835-0s7ok4uw	4251	28	us	-PRON-	PRP
cord-001835-0s7ok4uw	4251	29	to	to	TO
cord-001835-0s7ok4uw	4251	30	more	more	RBR
cord-001835-0s7ok4uw	4251	31	thoroughly	thoroughly	RB
cord-001835-0s7ok4uw	4251	32	investigate	investigate	VB
cord-001835-0s7ok4uw	4251	33	the	the	DT
cord-001835-0s7ok4uw	4251	34	successful	successful	JJ
cord-001835-0s7ok4uw	4251	35	and	and	CC
cord-001835-0s7ok4uw	4251	36	not	not	RB
cord-001835-0s7ok4uw	4251	37	-	-	HYPH
cord-001835-0s7ok4uw	4251	38	so	so	RB
cord-001835-0s7ok4uw	4251	39	-	-	HYPH
cord-001835-0s7ok4uw	4251	40	successful	successful	JJ
cord-001835-0s7ok4uw	4251	41	designs	design	NNS
cord-001835-0s7ok4uw	4251	42	,	,	,
cord-001835-0s7ok4uw	4251	43	and	and	CC
cord-001835-0s7ok4uw	4251	44	improve	improve	VB
cord-001835-0s7ok4uw	4251	45	the	the	DT
cord-001835-0s7ok4uw	4251	46	computational	computational	JJ
cord-001835-0s7ok4uw	4251	47	methods	method	NNS
cord-001835-0s7ok4uw	4251	48	.	.	.
cord-001835-0s7ok4uw	4252	1	Of	of	IN
cord-001835-0s7ok4uw	4252	2	3500	3500	CD
cord-001835-0s7ok4uw	4252	3	ligands	ligand	NNS
cord-001835-0s7ok4uw	4252	4	screened	screen	VBN
cord-001835-0s7ok4uw	4252	5	,	,	,
cord-001835-0s7ok4uw	4252	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	4252	7	identified	identify	VBD
cord-001835-0s7ok4uw	4252	8	28	28	CD
cord-001835-0s7ok4uw	4252	9	weakly	weakly	RB
cord-001835-0s7ok4uw	4252	10	-	-	HYPH
cord-001835-0s7ok4uw	4252	11	binding	bind	VBG
cord-001835-0s7ok4uw	4252	12	hits	hit	NNS
cord-001835-0s7ok4uw	4252	13	in	in	IN
cord-001835-0s7ok4uw	4252	14	the	the	DT
cord-001835-0s7ok4uw	4252	15	range	range	NN
cord-001835-0s7ok4uw	4252	16	of	of	IN
cord-001835-0s7ok4uw	4252	17	340	340	CD
cord-001835-0s7ok4uw	4252	18	-1110	-1110	NNS
cord-001835-0s7ok4uw	4252	19	mM.	mM.	VBN
cord-001835-0s7ok4uw	4253	1	Thus	thus	RB
cord-001835-0s7ok4uw	4253	2	far	far	RB
cord-001835-0s7ok4uw	4253	3	,	,	,
cord-001835-0s7ok4uw	4253	4	RosettaLigand	RosettaLigand	NNP
cord-001835-0s7ok4uw	4253	5	has	have	VBZ
cord-001835-0s7ok4uw	4253	6	successfully	successfully	RB
cord-001835-0s7ok4uw	4253	7	designed	design	VBN
cord-001835-0s7ok4uw	4253	8	one	one	CD
cord-001835-0s7ok4uw	4253	9	tighter	tight	JJR
cord-001835-0s7ok4uw	4253	10	protein	protein	NN
cord-001835-0s7ok4uw	4253	11	-	-	HYPH
cord-001835-0s7ok4uw	4253	12	ligand	ligand	NN
cord-001835-0s7ok4uw	4253	13	interface	interface	NN
cord-001835-0s7ok4uw	4253	14	,	,	,
cord-001835-0s7ok4uw	4253	15	from	from	IN
cord-001835-0s7ok4uw	4253	16	312	312	CD
cord-001835-0s7ok4uw	4253	17	mM	mm	CD
cord-001835-0s7ok4uw	4253	18	to	to	IN
cord-001835-0s7ok4uw	4253	19	21	21	CD
cord-001835-0s7ok4uw	4253	20	mM.	mM.	NNS
cord-001835-0s7ok4uw	4254	1	In	in	IN
cord-001835-0s7ok4uw	4254	2	progress	progress	NN
cord-001835-0s7ok4uw	4254	3	experiments	experiment	NNS
cord-001835-0s7ok4uw	4254	4	include	include	VBP
cord-001835-0s7ok4uw	4254	5	designing	design	VBG
cord-001835-0s7ok4uw	4254	6	and	and	CC
cord-001835-0s7ok4uw	4254	7	experimentally	experimentally	RB
cord-001835-0s7ok4uw	4254	8	validating	validate	VBG
cord-001835-0s7ok4uw	4254	9	more	more	RBR
cord-001835-0s7ok4uw	4254	10	designed	design	VBN
cord-001835-0s7ok4uw	4254	11	interfaces	interface	NNS
cord-001835-0s7ok4uw	4254	12	.	.	.
cord-001835-0s7ok4uw	4255	1	Structural	structural	JJ
cord-001835-0s7ok4uw	4255	2	studies	study	NNS
cord-001835-0s7ok4uw	4255	3	of	of	IN
cord-001835-0s7ok4uw	4255	4	human	human	JJ
cord-001835-0s7ok4uw	4255	5	acidic	acidic	JJ
cord-001835-0s7ok4uw	4255	6	fibroblast	fibroblast	NN
cord-001835-0s7ok4uw	4255	7	-	-	HYPH
cord-001835-0s7ok4uw	4255	8	growth	growth	NN
cord-001835-0s7ok4uw	4255	9	factor	factor	NN
cord-001835-0s7ok4uw	4255	10	(	(	-LRB-
cord-001835-0s7ok4uw	4255	11	FGF1	FGF1	NNP
cord-001835-0s7ok4uw	4255	12	)	)	-RRB-
cord-001835-0s7ok4uw	4255	13	mutants	mutant	NNS
cord-001835-0s7ok4uw	4255	14	with	with	IN
cord-001835-0s7ok4uw	4255	15	a	a	DT
cord-001835-0s7ok4uw	4255	16	probable	probable	JJ
cord-001835-0s7ok4uw	4255	17	anticancer	anticancer	JJ
cord-001835-0s7ok4uw	4255	18	activity	activity	NN
cord-001835-0s7ok4uw	4256	1	Lectins	lectin	NNS
cord-001835-0s7ok4uw	4256	2	are	be	VBP
cord-001835-0s7ok4uw	4256	3	carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	4256	4	-	-	HYPH
cord-001835-0s7ok4uw	4256	5	binding	bind	VBG
cord-001835-0s7ok4uw	4256	6	proteins	protein	NNS
cord-001835-0s7ok4uw	4256	7	ubiquitously	ubiquitously	RB
cord-001835-0s7ok4uw	4256	8	present	present	JJ
cord-001835-0s7ok4uw	4256	9	in	in	IN
cord-001835-0s7ok4uw	4256	10	nature	nature	NN
cord-001835-0s7ok4uw	4256	11	.	.	.
cord-001835-0s7ok4uw	4257	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	4257	2	play	play	VBP
cord-001835-0s7ok4uw	4257	3	a	a	DT
cord-001835-0s7ok4uw	4257	4	role	role	NN
cord-001835-0s7ok4uw	4257	5	in	in	IN
cord-001835-0s7ok4uw	4257	6	biological	biological	JJ
cord-001835-0s7ok4uw	4257	7	recognition	recognition	NN
cord-001835-0s7ok4uw	4257	8	phenomena	phenomenon	NNS
cord-001835-0s7ok4uw	4257	9	involving	involve	VBG
cord-001835-0s7ok4uw	4257	10	cells	cell	NNS
cord-001835-0s7ok4uw	4257	11	and	and	CC
cord-001835-0s7ok4uw	4257	12	proteins	protein	NNS
cord-001835-0s7ok4uw	4257	13	.	.	.
cord-001835-0s7ok4uw	4258	1	The	the	DT
cord-001835-0s7ok4uw	4258	2	interaction	interaction	NN
cord-001835-0s7ok4uw	4258	3	lectin	lectin	NN
cord-001835-0s7ok4uw	4258	4	-	-	HYPH
cord-001835-0s7ok4uw	4258	5	carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	4258	6	is	be	VBZ
cord-001835-0s7ok4uw	4258	7	highly	highly	RB
cord-001835-0s7ok4uw	4258	8	specific	specific	JJ
cord-001835-0s7ok4uw	4258	9	,	,	,
cord-001835-0s7ok4uw	4258	10	and	and	CC
cord-001835-0s7ok4uw	4258	11	can	can	MD
cord-001835-0s7ok4uw	4258	12	be	be	VB
cord-001835-0s7ok4uw	4258	13	exploited	exploit	VBN
cord-001835-0s7ok4uw	4258	14	for	for	IN
cord-001835-0s7ok4uw	4258	15	the	the	DT
cord-001835-0s7ok4uw	4258	16	development	development	NN
cord-001835-0s7ok4uw	4258	17	of	of	IN
cord-001835-0s7ok4uw	4258	18	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	4258	19	containing	contain	VBG
cord-001835-0s7ok4uw	4258	20	on	on	IN
cord-001835-0s7ok4uw	4258	21	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4258	22	surface	surface	NN
cord-001835-0s7ok4uw	4258	23	lectins	lectin	NNS
cord-001835-0s7ok4uw	4258	24	specifically	specifically	RB
cord-001835-0s7ok4uw	4258	25	directed	direct	VBN
cord-001835-0s7ok4uw	4258	26	to	to	IN
cord-001835-0s7ok4uw	4258	27	carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	4258	28	residues	residue	NNS
cord-001835-0s7ok4uw	4258	29	present	present	VBP
cord-001835-0s7ok4uw	4258	30	only	only	RB
cord-001835-0s7ok4uw	4258	31	on	on	IN
cord-001835-0s7ok4uw	4258	32	malignant	malignant	JJ
cord-001835-0s7ok4uw	4258	33	cells	cell	NNS
cord-001835-0s7ok4uw	4258	34	and	and	CC
cord-001835-0s7ok4uw	4258	35	absent	absent	JJ
cord-001835-0s7ok4uw	4258	36	on	on	IN
cord-001835-0s7ok4uw	4258	37	healthy	healthy	JJ
cord-001835-0s7ok4uw	4258	38	ones	one	NNS
cord-001835-0s7ok4uw	4258	39	(	(	-LRB-
cord-001835-0s7ok4uw	4258	40	1	1	CD
cord-001835-0s7ok4uw	4258	41	)	)	-RRB-
cord-001835-0s7ok4uw	4258	42	.	.	.
cord-001835-0s7ok4uw	4259	1	Lectins	lectin	NNS
cord-001835-0s7ok4uw	4259	2	have	have	VBP
cord-001835-0s7ok4uw	4259	3	been	be	VBN
cord-001835-0s7ok4uw	4259	4	found	find	VBN
cord-001835-0s7ok4uw	4259	5	to	to	TO
cord-001835-0s7ok4uw	4259	6	possess	possess	VB
cord-001835-0s7ok4uw	4259	7	anticancer	anticancer	JJ
cord-001835-0s7ok4uw	4259	8	properties	property	NNS
cord-001835-0s7ok4uw	4259	9	and	and	CC
cord-001835-0s7ok4uw	4259	10	they	-PRON-	PRP
cord-001835-0s7ok4uw	4259	11	are	be	VBP
cord-001835-0s7ok4uw	4259	12	proposed	propose	VBN
cord-001835-0s7ok4uw	4259	13	as	as	IN
cord-001835-0s7ok4uw	4259	14	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	4259	15	agents	agent	NNS
cord-001835-0s7ok4uw	4259	16	,	,	,
cord-001835-0s7ok4uw	4259	17	binding	bind	VBG
cord-001835-0s7ok4uw	4259	18	to	to	IN
cord-001835-0s7ok4uw	4259	19	cancer	cancer	NN
cord-001835-0s7ok4uw	4259	20	cell	cell	NN
cord-001835-0s7ok4uw	4259	21	membranes	membrane	NNS
cord-001835-0s7ok4uw	4259	22	or	or	CC
cord-001835-0s7ok4uw	4259	23	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4259	24	receptors	receptor	NNS
cord-001835-0s7ok4uw	4259	25	,	,	,
cord-001835-0s7ok4uw	4259	26	causing	cause	VBG
cord-001835-0s7ok4uw	4259	27	cytotoxicity	cytotoxicity	NN
cord-001835-0s7ok4uw	4259	28	,	,	,
cord-001835-0s7ok4uw	4259	29	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	4259	30	and	and	CC
cord-001835-0s7ok4uw	4259	31	inhibition	inhibition	NN
cord-001835-0s7ok4uw	4259	32	of	of	IN
cord-001835-0s7ok4uw	4259	33	tumor	tumor	NN
cord-001835-0s7ok4uw	4259	34	growth	growth	NN
cord-001835-0s7ok4uw	4259	35	.	.	.
cord-001835-0s7ok4uw	4260	1	Some	some	DT
cord-001835-0s7ok4uw	4260	2	lectins	lectin	NNS
cord-001835-0s7ok4uw	4260	3	are	be	VBP
cord-001835-0s7ok4uw	4260	4	able	able	JJ
cord-001835-0s7ok4uw	4260	5	to	to	TO
cord-001835-0s7ok4uw	4260	6	prevent	prevent	VB
cord-001835-0s7ok4uw	4260	7	the	the	DT
cord-001835-0s7ok4uw	4260	8	proliferation	proliferation	NN
cord-001835-0s7ok4uw	4260	9	of	of	IN
cord-001835-0s7ok4uw	4260	10	malignant	malignant	JJ
cord-001835-0s7ok4uw	4260	11	tumor	tumor	NN
cord-001835-0s7ok4uw	4260	12	cells	cell	NNS
cord-001835-0s7ok4uw	4260	13	because	because	IN
cord-001835-0s7ok4uw	4260	14	they	-PRON-	PRP
cord-001835-0s7ok4uw	4260	15	recognize	recognize	VBP
cord-001835-0s7ok4uw	4260	16	the	the	DT
cord-001835-0s7ok4uw	4260	17	T	T	NNP
cord-001835-0s7ok4uw	4260	18	-	-	HYPH
cord-001835-0s7ok4uw	4260	19	antigen	antigen	NN
cord-001835-0s7ok4uw	4260	20	(	(	-LRB-
cord-001835-0s7ok4uw	4260	21	Gal	gal	NN
cord-001835-0s7ok4uw	4260	22	b	b	NNP
cord-001835-0s7ok4uw	4260	23	1	1	CD
cord-001835-0s7ok4uw	4260	24	-	-	SYM
cord-001835-0s7ok4uw	4260	25	3GalNAc	3galnac	CD
cord-001835-0s7ok4uw	4260	26	)	)	-RRB-
cord-001835-0s7ok4uw	4260	27	found	find	VBD
cord-001835-0s7ok4uw	4260	28	specifically	specifically	RB
cord-001835-0s7ok4uw	4260	29	on	on	IN
cord-001835-0s7ok4uw	4260	30	the	the	DT
cord-001835-0s7ok4uw	4260	31	surface	surface	NN
cord-001835-0s7ok4uw	4260	32	of	of	IN
cord-001835-0s7ok4uw	4260	33	tumor	tumor	NN
cord-001835-0s7ok4uw	4260	34	cells	cell	NNS
cord-001835-0s7ok4uw	4260	35	(	(	-LRB-
cord-001835-0s7ok4uw	4260	36	2	2	CD
cord-001835-0s7ok4uw	4260	37	)	)	-RRB-
cord-001835-0s7ok4uw	4260	38	.	.	.
cord-001835-0s7ok4uw	4261	1	The	the	DT
cord-001835-0s7ok4uw	4261	2	main	main	JJ
cord-001835-0s7ok4uw	4261	3	problem	problem	NN
cord-001835-0s7ok4uw	4261	4	is	be	VBZ
cord-001835-0s7ok4uw	4261	5	that	that	IN
cord-001835-0s7ok4uw	4261	6	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4261	7	use	use	NN
cord-001835-0s7ok4uw	4261	8	as	as	IN
cord-001835-0s7ok4uw	4261	9	a	a	DT
cord-001835-0s7ok4uw	4261	10	detection	detection	NN
cord-001835-0s7ok4uw	4261	11	agent	agent	NN
cord-001835-0s7ok4uw	4261	12	for	for	IN
cord-001835-0s7ok4uw	4261	13	the	the	DT
cord-001835-0s7ok4uw	4261	14	T	T	NNP
cord-001835-0s7ok4uw	4261	15	-	-	HYPH
cord-001835-0s7ok4uw	4261	16	antigen	antigen	NN
cord-001835-0s7ok4uw	4261	17	in	in	IN
cord-001835-0s7ok4uw	4261	18	clinical	clinical	JJ
cord-001835-0s7ok4uw	4261	19	studies	study	NNS
cord-001835-0s7ok4uw	4261	20	is	be	VBZ
cord-001835-0s7ok4uw	4261	21	not	not	RB
cord-001835-0s7ok4uw	4261	22	possible	possible	JJ
cord-001835-0s7ok4uw	4261	23	because	because	IN
cord-001835-0s7ok4uw	4261	24	the	the	DT
cord-001835-0s7ok4uw	4261	25	immune	immune	JJ
cord-001835-0s7ok4uw	4261	26	system	system	NN
cord-001835-0s7ok4uw	4261	27	can	can	MD
cord-001835-0s7ok4uw	4261	28	recognize	recognize	VB
cord-001835-0s7ok4uw	4261	29	them	-PRON-	PRP
cord-001835-0s7ok4uw	4261	30	as	as	IN
cord-001835-0s7ok4uw	4261	31	foreign	foreign	JJ
cord-001835-0s7ok4uw	4261	32	molecules	molecule	NNS
cord-001835-0s7ok4uw	4261	33	and	and	CC
cord-001835-0s7ok4uw	4261	34	develop	develop	VB
cord-001835-0s7ok4uw	4261	35	an	an	DT
cord-001835-0s7ok4uw	4261	36	immune	immune	JJ
cord-001835-0s7ok4uw	4261	37	response	response	NN
cord-001835-0s7ok4uw	4261	38	.	.	.
cord-001835-0s7ok4uw	4262	1	Previous	previous	JJ
cord-001835-0s7ok4uw	4262	2	studies	study	NNS
cord-001835-0s7ok4uw	4262	3	with	with	IN
cord-001835-0s7ok4uw	4262	4	X	x	NN
cord-001835-0s7ok4uw	4262	5	-	-	NN
cord-001835-0s7ok4uw	4262	6	ray	ray	NN
cord-001835-0s7ok4uw	4262	7	crystallography	crystallography	NN
cord-001835-0s7ok4uw	4262	8	made	make	VBN
cord-001835-0s7ok4uw	4262	9	in	in	IN
cord-001835-0s7ok4uw	4262	10	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4262	11	laboratory	laboratory	NN
cord-001835-0s7ok4uw	4262	12	have	have	VBP
cord-001835-0s7ok4uw	4262	13	characterized	characterize	VBN
cord-001835-0s7ok4uw	4262	14	a	a	DT
cord-001835-0s7ok4uw	4262	15	lectin	lectin	NN
cord-001835-0s7ok4uw	4262	16	found	find	VBN
cord-001835-0s7ok4uw	4262	17	in	in	IN
cord-001835-0s7ok4uw	4262	18	mushrooms	mushroom	NNS
cord-001835-0s7ok4uw	4262	19	called	call	VBN
cord-001835-0s7ok4uw	4262	20	BEL	BEL	NNP
cord-001835-0s7ok4uw	4262	21	b	b	NNP
cord-001835-0s7ok4uw	4262	22	-	-	HYPH
cord-001835-0s7ok4uw	4262	23	trefoil	trefoil	NNP
cord-001835-0s7ok4uw	4262	24	which	which	WDT
cord-001835-0s7ok4uw	4262	25	has	have	VBZ
cord-001835-0s7ok4uw	4262	26	antiproliferative	antiproliferative	JJ
cord-001835-0s7ok4uw	4262	27	activity	activity	NN
cord-001835-0s7ok4uw	4262	28	on	on	IN
cord-001835-0s7ok4uw	4262	29	tumor	tumor	NN
cord-001835-0s7ok4uw	4262	30	cell	cell	NN
cord-001835-0s7ok4uw	4262	31	lines	line	NNS
cord-001835-0s7ok4uw	4262	32	,	,	,
cord-001835-0s7ok4uw	4262	33	because	because	IN
cord-001835-0s7ok4uw	4262	34	it	-PRON-	PRP
cord-001835-0s7ok4uw	4262	35	contains	contain	VBZ
cord-001835-0s7ok4uw	4262	36	three	three	CD
cord-001835-0s7ok4uw	4262	37	binding	bind	VBG
cord-001835-0s7ok4uw	4262	38	sites	site	NNS
cord-001835-0s7ok4uw	4262	39	for	for	IN
cord-001835-0s7ok4uw	4262	40	the	the	DT
cord-001835-0s7ok4uw	4262	41	T	T	NNP
cord-001835-0s7ok4uw	4262	42	-	-	HYPH
cord-001835-0s7ok4uw	4262	43	antigen	antigen	NNP
cord-001835-0s7ok4uw	4262	44	.	.	.
cord-001835-0s7ok4uw	4263	1	Unlike	unlike	IN
cord-001835-0s7ok4uw	4263	2	other	other	JJ
cord-001835-0s7ok4uw	4263	3	lectins	lectin	NNS
cord-001835-0s7ok4uw	4263	4	with	with	IN
cord-001835-0s7ok4uw	4263	5	this	this	DT
cord-001835-0s7ok4uw	4263	6	property	property	NN
cord-001835-0s7ok4uw	4263	7	,	,	,
cord-001835-0s7ok4uw	4263	8	BEL	BEL	NNP
cord-001835-0s7ok4uw	4263	9	b	b	NNP
cord-001835-0s7ok4uw	4263	10	-	-	HYPH
cord-001835-0s7ok4uw	4263	11	trefoil	trefoil	NNP
cord-001835-0s7ok4uw	4263	12	shows	show	VBZ
cord-001835-0s7ok4uw	4263	13	structural	structural	JJ
cord-001835-0s7ok4uw	4263	14	homology	homology	NN
cord-001835-0s7ok4uw	4263	15	with	with	IN
cord-001835-0s7ok4uw	4263	16	a	a	DT
cord-001835-0s7ok4uw	4263	17	human	human	JJ
cord-001835-0s7ok4uw	4263	18	protein	protein	NN
cord-001835-0s7ok4uw	4263	19	,	,	,
cord-001835-0s7ok4uw	4263	20	acidic	acidic	JJ
cord-001835-0s7ok4uw	4263	21	Fibroblast	Fibroblast	NNP
cord-001835-0s7ok4uw	4263	22	Growth	Growth	NNP
cord-001835-0s7ok4uw	4263	23	Factor	Factor	NNP
cord-001835-0s7ok4uw	4263	24	(	(	-LRB-
cord-001835-0s7ok4uw	4263	25	FGF1	FGF1	NNP
cord-001835-0s7ok4uw	4263	26	)	)	-RRB-
cord-001835-0s7ok4uw	4264	1	(	(	-LRB-
cord-001835-0s7ok4uw	4264	2	3	3	CD
cord-001835-0s7ok4uw	4264	3	)	)	-RRB-
cord-001835-0s7ok4uw	4264	4	.	.	.
cord-001835-0s7ok4uw	4265	1	Superposition	superposition	NN
cord-001835-0s7ok4uw	4265	2	of	of	IN
cord-001835-0s7ok4uw	4265	3	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4265	4	structures	structure	NNS
cord-001835-0s7ok4uw	4265	5	suggests	suggest	VBZ
cord-001835-0s7ok4uw	4265	6	that	that	IN
cord-001835-0s7ok4uw	4265	7	the	the	DT
cord-001835-0s7ok4uw	4265	8	human	human	JJ
cord-001835-0s7ok4uw	4265	9	protein	protein	NN
cord-001835-0s7ok4uw	4265	10	could	could	MD
cord-001835-0s7ok4uw	4265	11	be	be	VB
cord-001835-0s7ok4uw	4265	12	mutated	mutate	VBN
cord-001835-0s7ok4uw	4265	13	to	to	TO
cord-001835-0s7ok4uw	4265	14	contain	contain	VB
cord-001835-0s7ok4uw	4265	15	at	at	IN
cord-001835-0s7ok4uw	4265	16	least	least	RBS
cord-001835-0s7ok4uw	4265	17	one	one	CD
cord-001835-0s7ok4uw	4265	18	of	of	IN
cord-001835-0s7ok4uw	4265	19	the	the	DT
cord-001835-0s7ok4uw	4265	20	binding	bind	VBG
cord-001835-0s7ok4uw	4265	21	sites	site	NNS
cord-001835-0s7ok4uw	4265	22	for	for	IN
cord-001835-0s7ok4uw	4265	23	the	the	DT
cord-001835-0s7ok4uw	4265	24	T	T	NNP
cord-001835-0s7ok4uw	4265	25	-	-	HYPH
cord-001835-0s7ok4uw	4265	26	antigen	antigen	NNP
cord-001835-0s7ok4uw	4265	27	.	.	.
cord-001835-0s7ok4uw	4266	1	Such	such	JJ
cord-001835-0s7ok4uw	4266	2	mutations	mutation	NNS
cord-001835-0s7ok4uw	4266	3	should	should	MD
cord-001835-0s7ok4uw	4266	4	create	create	VB
cord-001835-0s7ok4uw	4266	5	in	in	IN
cord-001835-0s7ok4uw	4266	6	FGF1	FGF1	NNP
cord-001835-0s7ok4uw	4266	7	the	the	DT
cord-001835-0s7ok4uw	4266	8	potential	potential	JJ
cord-001835-0s7ok4uw	4266	9	capacity	capacity	NN
cord-001835-0s7ok4uw	4266	10	of	of	IN
cord-001835-0s7ok4uw	4266	11	recognizing	recognize	VBG
cord-001835-0s7ok4uw	4266	12	tumor	tumor	NN
cord-001835-0s7ok4uw	4266	13	cells	cell	NNS
cord-001835-0s7ok4uw	4266	14	with	with	IN
cord-001835-0s7ok4uw	4266	15	less	less	JJR
cord-001835-0s7ok4uw	4266	16	immunogenicity	immunogenicity	NN
cord-001835-0s7ok4uw	4266	17	than	than	IN
cord-001835-0s7ok4uw	4266	18	the	the	DT
cord-001835-0s7ok4uw	4266	19	fungal	fungal	JJ
cord-001835-0s7ok4uw	4266	20	protein	protein	NN
cord-001835-0s7ok4uw	4266	21	.	.	.
cord-001835-0s7ok4uw	4267	1	FGF1	FGF1	NNP
cord-001835-0s7ok4uw	4267	2	is	be	VBZ
cord-001835-0s7ok4uw	4267	3	mitogenic	mitogenic	NNP
cord-001835-0s7ok4uw	4267	4	and	and	CC
cord-001835-0s7ok4uw	4267	5	chemotactic	chemotactic	JJ
cord-001835-0s7ok4uw	4267	6	,	,	,
cord-001835-0s7ok4uw	4267	7	and	and	CC
cord-001835-0s7ok4uw	4267	8	mediates	mediate	VBZ
cord-001835-0s7ok4uw	4267	9	cellular	cellular	JJ
cord-001835-0s7ok4uw	4267	10	functions	function	NNS
cord-001835-0s7ok4uw	4267	11	by	by	IN
cord-001835-0s7ok4uw	4267	12	binding	bind	VBG
cord-001835-0s7ok4uw	4267	13	to	to	IN
cord-001835-0s7ok4uw	4267	14	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	4267	15	receptors	receptor	NNS
cord-001835-0s7ok4uw	4267	16	,	,	,
cord-001835-0s7ok4uw	4267	17	which	which	WDT
cord-001835-0s7ok4uw	4267	18	are	be	VBP
cord-001835-0s7ok4uw	4267	19	activated	activate	VBN
cord-001835-0s7ok4uw	4267	20	by	by	IN
cord-001835-0s7ok4uw	4267	21	ligand	ligand	NN
cord-001835-0s7ok4uw	4267	22	-	-	HYPH
cord-001835-0s7ok4uw	4267	23	induced	induce	VBN
cord-001835-0s7ok4uw	4267	24	dimerization	dimerization	NN
cord-001835-0s7ok4uw	4267	25	requiring	require	VBG
cord-001835-0s7ok4uw	4267	26	heparin	heparin	NN
cord-001835-0s7ok4uw	4267	27	as	as	IN
cord-001835-0s7ok4uw	4267	28	co	co	NN
cord-001835-0s7ok4uw	4267	29	-	-	NN
cord-001835-0s7ok4uw	4267	30	receptor	receptor	NN
cord-001835-0s7ok4uw	4267	31	.	.	.
cord-001835-0s7ok4uw	4268	1	To	to	TO
cord-001835-0s7ok4uw	4268	2	reach	reach	VB
cord-001835-0s7ok4uw	4268	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4268	4	purpose	purpose	NN
cord-001835-0s7ok4uw	4268	5	,	,	,
cord-001835-0s7ok4uw	4268	6	the	the	DT
cord-001835-0s7ok4uw	4268	7	FGF1	FGF1	NNP
cord-001835-0s7ok4uw	4268	8	cDNA	cdna	NN
cord-001835-0s7ok4uw	4268	9	was	be	VBD
cord-001835-0s7ok4uw	4268	10	cloned	clone	VBN
cord-001835-0s7ok4uw	4268	11	into	into	IN
cord-001835-0s7ok4uw	4268	12	a	a	DT
cord-001835-0s7ok4uw	4268	13	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	4268	14	plasmid	plasmid	NN
cord-001835-0s7ok4uw	4268	15	and	and	CC
cord-001835-0s7ok4uw	4268	16	then	then	RB
cord-001835-0s7ok4uw	4268	17	mutated	mutate	VBN
cord-001835-0s7ok4uw	4268	18	in	in	IN
cord-001835-0s7ok4uw	4268	19	five	five	CD
cord-001835-0s7ok4uw	4268	20	different	different	JJ
cord-001835-0s7ok4uw	4268	21	positions	position	NNS
cord-001835-0s7ok4uw	4268	22	to	to	TO
cord-001835-0s7ok4uw	4268	23	eliminate	eliminate	VB
cord-001835-0s7ok4uw	4268	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4268	25	mitogenic	mitogenic	JJ
cord-001835-0s7ok4uw	4268	26	activity	activity	NN
cord-001835-0s7ok4uw	4268	27	and	and	CC
cord-001835-0s7ok4uw	4268	28	to	to	TO
cord-001835-0s7ok4uw	4268	29	engineer	engineer	VB
cord-001835-0s7ok4uw	4268	30	in	in	IN
cord-001835-0s7ok4uw	4268	31	the	the	DT
cord-001835-0s7ok4uw	4268	32	protein	protein	NN
cord-001835-0s7ok4uw	4268	33	the	the	DT
cord-001835-0s7ok4uw	4268	34	T	T	NNP
cord-001835-0s7ok4uw	4268	35	-	-	HYPH
cord-001835-0s7ok4uw	4268	36	antigen	antigen	NN
cord-001835-0s7ok4uw	4268	37	binding	binding	NN
cord-001835-0s7ok4uw	4268	38	capacity	capacity	NN
cord-001835-0s7ok4uw	4268	39	.	.	.
cord-001835-0s7ok4uw	4269	1	Attempts	attempt	NNS
cord-001835-0s7ok4uw	4269	2	to	to	TO
cord-001835-0s7ok4uw	4269	3	crystalize	crystalize	VB
cord-001835-0s7ok4uw	4269	4	the	the	DT
cord-001835-0s7ok4uw	4269	5	mutants	mutant	NNS
cord-001835-0s7ok4uw	4269	6	of	of	IN
cord-001835-0s7ok4uw	4269	7	FGF1	FGF1	NNP
cord-001835-0s7ok4uw	4269	8	were	be	VBD
cord-001835-0s7ok4uw	4269	9	made	make	VBN
cord-001835-0s7ok4uw	4269	10	using	use	VBG
cord-001835-0s7ok4uw	4269	11	the	the	DT
cord-001835-0s7ok4uw	4269	12	hanging	hang	VBG
cord-001835-0s7ok4uw	4269	13	drop	drop	NN
cord-001835-0s7ok4uw	4269	14	technique	technique	NN
cord-001835-0s7ok4uw	4269	15	with	with	IN
cord-001835-0s7ok4uw	4269	16	the	the	DT
cord-001835-0s7ok4uw	4269	17	final	final	JJ
cord-001835-0s7ok4uw	4269	18	aim	aim	NN
cord-001835-0s7ok4uw	4269	19	to	to	TO
cord-001835-0s7ok4uw	4269	20	carry	carry	VB
cord-001835-0s7ok4uw	4269	21	out	out	RP
cord-001835-0s7ok4uw	4269	22	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4269	23	structural	structural	JJ
cord-001835-0s7ok4uw	4269	24	characterization	characterization	NN
cord-001835-0s7ok4uw	4269	25	by	by	IN
cord-001835-0s7ok4uw	4269	26	X	x	NN
cord-001835-0s7ok4uw	4269	27	-	-	NN
cord-001835-0s7ok4uw	4269	28	ray	ray	NN
cord-001835-0s7ok4uw	4269	29	diffraction	diffraction	NN
cord-001835-0s7ok4uw	4269	30	analysis	analysis	NN
cord-001835-0s7ok4uw	4269	31	of	of	IN
cord-001835-0s7ok4uw	4269	32	the	the	DT
cord-001835-0s7ok4uw	4269	33	crystals	crystal	NNS
cord-001835-0s7ok4uw	4269	34	.	.	.
cord-001835-0s7ok4uw	4270	1	The	the	DT
cord-001835-0s7ok4uw	4270	2	de	de	FW
cord-001835-0s7ok4uw	4270	3	novo	novo	NNP
cord-001835-0s7ok4uw	4270	4	synthesis	synthesis	NN
cord-001835-0s7ok4uw	4270	5	of	of	IN
cord-001835-0s7ok4uw	4270	6	proteins	protein	NNS
cord-001835-0s7ok4uw	4270	7	in	in	IN
cord-001835-0s7ok4uw	4270	8	response	response	NN
cord-001835-0s7ok4uw	4270	9	to	to	IN
cord-001835-0s7ok4uw	4270	10	the	the	DT
cord-001835-0s7ok4uw	4270	11	activation	activation	NN
cord-001835-0s7ok4uw	4270	12	of	of	IN
cord-001835-0s7ok4uw	4270	13	cellular	cellular	JJ
cord-001835-0s7ok4uw	4270	14	signaling	signal	VBG
cord-001835-0s7ok4uw	4270	15	pathways	pathway	NNS
cord-001835-0s7ok4uw	4270	16	is	be	VBZ
cord-001835-0s7ok4uw	4270	17	a	a	DT
cord-001835-0s7ok4uw	4270	18	crucial	crucial	JJ
cord-001835-0s7ok4uw	4270	19	element	element	NN
cord-001835-0s7ok4uw	4270	20	of	of	IN
cord-001835-0s7ok4uw	4270	21	many	many	JJ
cord-001835-0s7ok4uw	4270	22	high	high	JJ
cord-001835-0s7ok4uw	4270	23	-	-	HYPH
cord-001835-0s7ok4uw	4270	24	level	level	NN
cord-001835-0s7ok4uw	4270	25	biological	biological	JJ
cord-001835-0s7ok4uw	4270	26	processes	process	NNS
cord-001835-0s7ok4uw	4270	27	,	,	,
cord-001835-0s7ok4uw	4270	28	including	include	VBG
cord-001835-0s7ok4uw	4270	29	the	the	DT
cord-001835-0s7ok4uw	4270	30	synaptic	synaptic	JJ
cord-001835-0s7ok4uw	4270	31	plasticity	plasticity	NN
cord-001835-0s7ok4uw	4270	32	underpinning	underpin	VBG
cord-001835-0s7ok4uw	4270	33	memory	memory	NN
cord-001835-0s7ok4uw	4270	34	formation	formation	NN
cord-001835-0s7ok4uw	4270	35	in	in	IN
cord-001835-0s7ok4uw	4270	36	the	the	DT
cord-001835-0s7ok4uw	4270	37	brain	brain	NN
cord-001835-0s7ok4uw	4270	38	.	.	.
cord-001835-0s7ok4uw	4271	1	While	while	IN
cord-001835-0s7ok4uw	4271	2	of	of	IN
cord-001835-0s7ok4uw	4271	3	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	4271	4	biological	biological	JJ
cord-001835-0s7ok4uw	4271	5	importance	importance	NN
cord-001835-0s7ok4uw	4271	6	,	,	,
cord-001835-0s7ok4uw	4271	7	there	there	EX
cord-001835-0s7ok4uw	4271	8	has	have	VBZ
cord-001835-0s7ok4uw	4271	9	been	be	VBN
cord-001835-0s7ok4uw	4271	10	a	a	DT
cord-001835-0s7ok4uw	4271	11	shortage	shortage	NN
cord-001835-0s7ok4uw	4271	12	of	of	IN
cord-001835-0s7ok4uw	4271	13	tools	tool	NNS
cord-001835-0s7ok4uw	4271	14	with	with	IN
cord-001835-0s7ok4uw	4271	15	which	which	WDT
cord-001835-0s7ok4uw	4271	16	to	to	TO
cord-001835-0s7ok4uw	4271	17	specifically	specifically	RB
cord-001835-0s7ok4uw	4271	18	target	target	VB
cord-001835-0s7ok4uw	4271	19	pools	pool	NNS
cord-001835-0s7ok4uw	4271	20	of	of	IN
cord-001835-0s7ok4uw	4271	21	newly	newly	RB
cord-001835-0s7ok4uw	4271	22	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	4271	23	proteins	protein	NNS
cord-001835-0s7ok4uw	4271	24	of	of	IN
cord-001835-0s7ok4uw	4271	25	interest	interest	NN
cord-001835-0s7ok4uw	4271	26	for	for	IN
cord-001835-0s7ok4uw	4271	27	study	study	NN
cord-001835-0s7ok4uw	4271	28	.	.	.
cord-001835-0s7ok4uw	4272	1	Thus	thus	RB
cord-001835-0s7ok4uw	4272	2	,	,	,
cord-001835-0s7ok4uw	4272	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4272	4	have	have	VBP
cord-001835-0s7ok4uw	4272	5	developed	develop	VBN
cord-001835-0s7ok4uw	4272	6	TimeSTAMP	TimeSTAMP	NNP
cord-001835-0s7ok4uw	4272	7	and	and	CC
cord-001835-0s7ok4uw	4272	8	SMASh	SMASh	NNS
cord-001835-0s7ok4uw	4272	9	,	,	,
cord-001835-0s7ok4uw	4272	10	methods	method	NNS
cord-001835-0s7ok4uw	4272	11	for	for	IN
cord-001835-0s7ok4uw	4272	12	drug	drug	NN
cord-001835-0s7ok4uw	4272	13	-	-	HYPH
cord-001835-0s7ok4uw	4272	14	dependent	dependent	JJ
cord-001835-0s7ok4uw	4272	15	tagging	tagging	NN
cord-001835-0s7ok4uw	4272	16	,	,	,
cord-001835-0s7ok4uw	4272	17	or	or	CC
cord-001835-0s7ok4uw	4272	18	destruction	destruction	NN
cord-001835-0s7ok4uw	4272	19	,	,	,
cord-001835-0s7ok4uw	4272	20	respectively	respectively	RB
cord-001835-0s7ok4uw	4272	21	,	,	,
cord-001835-0s7ok4uw	4272	22	of	of	IN
cord-001835-0s7ok4uw	4272	23	newly	newly	RB
cord-001835-0s7ok4uw	4272	24	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	4272	25	copies	copy	NNS
cord-001835-0s7ok4uw	4272	26	of	of	IN
cord-001835-0s7ok4uw	4272	27	proteins	protein	NNS
cord-001835-0s7ok4uw	4272	28	of	of	IN
cord-001835-0s7ok4uw	4272	29	interest	interest	NN
cord-001835-0s7ok4uw	4272	30	.	.	.
cord-001835-0s7ok4uw	4273	1	Both	both	DT
cord-001835-0s7ok4uw	4273	2	methods	method	NNS
cord-001835-0s7ok4uw	4273	3	rely	rely	VBP
cord-001835-0s7ok4uw	4273	4	on	on	IN
cord-001835-0s7ok4uw	4273	5	protein	protein	NN
cord-001835-0s7ok4uw	4273	6	tags	tag	NNS
cord-001835-0s7ok4uw	4273	7	that	that	WDT
cord-001835-0s7ok4uw	4273	8	remove	remove	VBP
cord-001835-0s7ok4uw	4273	9	themselves	-PRON-	PRP
cord-001835-0s7ok4uw	4273	10	by	by	IN
cord-001835-0s7ok4uw	4273	11	default	default	NN
cord-001835-0s7ok4uw	4273	12	via	via	IN
cord-001835-0s7ok4uw	4273	13	an	an	DT
cord-001835-0s7ok4uw	4273	14	internal	internal	JJ
cord-001835-0s7ok4uw	4273	15	Hepatitis	Hepatitis	NNP
cord-001835-0s7ok4uw	4273	16	C	C	NNP
cord-001835-0s7ok4uw	4273	17	Virus	virus	NN
cord-001835-0s7ok4uw	4273	18	(	(	-LRB-
cord-001835-0s7ok4uw	4273	19	HCV	HCV	NNP
cord-001835-0s7ok4uw	4273	20	)	)	-RRB-
cord-001835-0s7ok4uw	4273	21	NS3	ns3	RB
cord-001835-0s7ok4uw	4273	22	protease	protease	NN
cord-001835-0s7ok4uw	4273	23	,	,	,
cord-001835-0s7ok4uw	4273	24	but	but	CC
cord-001835-0s7ok4uw	4273	25	which	which	WDT
cord-001835-0s7ok4uw	4273	26	are	be	VBP
cord-001835-0s7ok4uw	4273	27	retained	retain	VBN
cord-001835-0s7ok4uw	4273	28	in	in	IN
cord-001835-0s7ok4uw	4273	29	the	the	DT
cord-001835-0s7ok4uw	4273	30	presence	presence	NN
cord-001835-0s7ok4uw	4273	31	of	of	IN
cord-001835-0s7ok4uw	4273	32	cell	cell	NN
cord-001835-0s7ok4uw	4273	33	-	-	HYPH
cord-001835-0s7ok4uw	4273	34	permeable	permeable	JJ
cord-001835-0s7ok4uw	4273	35	small	small	JJ
cord-001835-0s7ok4uw	4273	36	molecule	molecule	NN
cord-001835-0s7ok4uw	4273	37	protease	protease	NN
cord-001835-0s7ok4uw	4273	38	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4273	39	.	.	.
cord-001835-0s7ok4uw	4274	1	The	the	DT
cord-001835-0s7ok4uw	4274	2	TimeSTAMP	TimeSTAMP	NNP
cord-001835-0s7ok4uw	4274	3	tag	tag	NN
cord-001835-0s7ok4uw	4274	4	contains	contain	VBZ
cord-001835-0s7ok4uw	4274	5	split	split	VBN
cord-001835-0s7ok4uw	4274	6	YFP	YFP	NNP
cord-001835-0s7ok4uw	4274	7	halves	half	NNS
cord-001835-0s7ok4uw	4274	8	and	and	CC
cord-001835-0s7ok4uw	4274	9	epitope	epitope	NN
cord-001835-0s7ok4uw	4274	10	tags	tag	NNS
cord-001835-0s7ok4uw	4274	11	which	which	WDT
cord-001835-0s7ok4uw	4274	12	are	be	VBP
cord-001835-0s7ok4uw	4274	13	reconstituted	reconstitute	VBN
cord-001835-0s7ok4uw	4274	14	and	and	CC
cord-001835-0s7ok4uw	4274	15	preserved	preserve	VBN
cord-001835-0s7ok4uw	4274	16	,	,	,
cord-001835-0s7ok4uw	4274	17	respectively	respectively	RB
cord-001835-0s7ok4uw	4274	18	,	,	,
cord-001835-0s7ok4uw	4274	19	on	on	IN
cord-001835-0s7ok4uw	4274	20	proteins	protein	NNS
cord-001835-0s7ok4uw	4274	21	of	of	IN
cord-001835-0s7ok4uw	4274	22	interest	interest	NN
cord-001835-0s7ok4uw	4274	23	following	follow	VBG
cord-001835-0s7ok4uw	4274	24	drug	drug	NN
cord-001835-0s7ok4uw	4274	25	application	application	NN
cord-001835-0s7ok4uw	4274	26	,	,	,
cord-001835-0s7ok4uw	4274	27	whereas	whereas	IN
cord-001835-0s7ok4uw	4274	28	the	the	DT
cord-001835-0s7ok4uw	4274	29	SMASh	SMASh	NNS
cord-001835-0s7ok4uw	4274	30	tag	tag	NN
cord-001835-0s7ok4uw	4274	31	contains	contain	VBZ
cord-001835-0s7ok4uw	4274	32	a	a	DT
cord-001835-0s7ok4uw	4274	33	strong	strong	JJ
cord-001835-0s7ok4uw	4274	34	degron	degron	NN
cord-001835-0s7ok4uw	4274	35	which	which	WDT
cord-001835-0s7ok4uw	4274	36	remains	remain	VBZ
cord-001835-0s7ok4uw	4274	37	attached	attach	VBN
cord-001835-0s7ok4uw	4274	38	to	to	IN
cord-001835-0s7ok4uw	4274	39	proteins	protein	NNS
cord-001835-0s7ok4uw	4274	40	of	of	IN
cord-001835-0s7ok4uw	4274	41	interest	interest	NN
cord-001835-0s7ok4uw	4274	42	following	follow	VBG
cord-001835-0s7ok4uw	4274	43	drug	drug	NN
cord-001835-0s7ok4uw	4274	44	application	application	NN
cord-001835-0s7ok4uw	4274	45	,	,	,
cord-001835-0s7ok4uw	4274	46	resulting	result	VBG
cord-001835-0s7ok4uw	4274	47	in	in	IN
cord-001835-0s7ok4uw	4274	48	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4274	49	clearance	clearance	NN
cord-001835-0s7ok4uw	4274	50	.	.	.
cord-001835-0s7ok4uw	4275	1	One	one	CD
cord-001835-0s7ok4uw	4275	2	limitation	limitation	NN
cord-001835-0s7ok4uw	4275	3	of	of	IN
cord-001835-0s7ok4uw	4275	4	Time	Time	NNP
cord-001835-0s7ok4uw	4275	5	-	-	HYPH
cord-001835-0s7ok4uw	4275	6	STAMP	STAMP	NNP
cord-001835-0s7ok4uw	4275	7	and	and	CC
cord-001835-0s7ok4uw	4275	8	SMASh	SMASh	NNS
cord-001835-0s7ok4uw	4275	9	is	be	VBZ
cord-001835-0s7ok4uw	4275	10	that	that	IN
cord-001835-0s7ok4uw	4275	11	they	-PRON-	PRP
cord-001835-0s7ok4uw	4275	12	can	can	MD
cord-001835-0s7ok4uw	4275	13	only	only	RB
cord-001835-0s7ok4uw	4275	14	be	be	VB
cord-001835-0s7ok4uw	4275	15	used	use	VBN
cord-001835-0s7ok4uw	4275	16	to	to	TO
cord-001835-0s7ok4uw	4275	17	independently	independently	RB
cord-001835-0s7ok4uw	4275	18	manipulate	manipulate	VB
cord-001835-0s7ok4uw	4275	19	one	one	CD
cord-001835-0s7ok4uw	4275	20	protein	protein	NN
cord-001835-0s7ok4uw	4275	21	of	of	IN
cord-001835-0s7ok4uw	4275	22	interest	interest	NN
cord-001835-0s7ok4uw	4275	23	at	at	IN
cord-001835-0s7ok4uw	4275	24	a	a	DT
cord-001835-0s7ok4uw	4275	25	time	time	NN
cord-001835-0s7ok4uw	4275	26	.	.	.
cord-001835-0s7ok4uw	4276	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	4276	2	,	,	,
cord-001835-0s7ok4uw	4276	3	the	the	DT
cord-001835-0s7ok4uw	4276	4	application	application	NN
cord-001835-0s7ok4uw	4276	5	of	of	IN
cord-001835-0s7ok4uw	4276	6	TimeSTAMP	TimeSTAMP	NNP
cord-001835-0s7ok4uw	4276	7	and	and	CC
cord-001835-0s7ok4uw	4276	8	SMASh	SMASh	NNS
cord-001835-0s7ok4uw	4276	9	to	to	TO
cord-001835-0s7ok4uw	4276	10	study	study	VB
cord-001835-0s7ok4uw	4276	11	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	4276	12	protein	protein	NN
cord-001835-0s7ok4uw	4276	13	pools	pool	NNS
cord-001835-0s7ok4uw	4276	14	in	in	IN
cord-001835-0s7ok4uw	4276	15	mammals	mammal	NNS
cord-001835-0s7ok4uw	4276	16	has	have	VBZ
cord-001835-0s7ok4uw	4276	17	not	not	RB
cord-001835-0s7ok4uw	4276	18	yet	yet	RB
cord-001835-0s7ok4uw	4276	19	been	be	VBN
cord-001835-0s7ok4uw	4276	20	explored	explore	VBN
cord-001835-0s7ok4uw	4276	21	.	.	.
cord-001835-0s7ok4uw	4277	1	Here	here	RB
cord-001835-0s7ok4uw	4277	2	,	,	,
cord-001835-0s7ok4uw	4277	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4277	4	report	report	VBP
cord-001835-0s7ok4uw	4277	5	on	on	IN
cord-001835-0s7ok4uw	4277	6	efforts	effort	NNS
cord-001835-0s7ok4uw	4277	7	to	to	TO
cord-001835-0s7ok4uw	4277	8	extend	extend	VB
cord-001835-0s7ok4uw	4277	9	these	these	DT
cord-001835-0s7ok4uw	4277	10	techniques	technique	NNS
cord-001835-0s7ok4uw	4277	11	by	by	IN
cord-001835-0s7ok4uw	4277	12	reengineering	reengineere	VBG
cord-001835-0s7ok4uw	4277	13	NS3	ns3	RB
cord-001835-0s7ok4uw	4277	14	proteases	protease	NNS
cord-001835-0s7ok4uw	4277	15	which	which	WDT
cord-001835-0s7ok4uw	4277	16	can	can	MD
cord-001835-0s7ok4uw	4277	17	be	be	VB
cord-001835-0s7ok4uw	4277	18	inhibited	inhibit	VBN
cord-001835-0s7ok4uw	4277	19	by	by	IN
cord-001835-0s7ok4uw	4277	20	two	two	CD
cord-001835-0s7ok4uw	4277	21	different	different	JJ
cord-001835-0s7ok4uw	4277	22	drugs	drug	NNS
cord-001835-0s7ok4uw	4277	23	orthogonally	orthogonally	RB
cord-001835-0s7ok4uw	4277	24	to	to	IN
cord-001835-0s7ok4uw	4277	25	one	one	CD
cord-001835-0s7ok4uw	4277	26	another	another	DT
cord-001835-0s7ok4uw	4277	27	.	.	.
cord-001835-0s7ok4uw	4278	1	By	by	IN
cord-001835-0s7ok4uw	4278	2	incorporating	incorporate	VBG
cord-001835-0s7ok4uw	4278	3	different	different	JJ
cord-001835-0s7ok4uw	4278	4	drug	drug	NN
cord-001835-0s7ok4uw	4278	5	resistance	resistance	NN
cord-001835-0s7ok4uw	4278	6	mutations	mutation	NNS
cord-001835-0s7ok4uw	4278	7	into	into	IN
cord-001835-0s7ok4uw	4278	8	two	two	CD
cord-001835-0s7ok4uw	4278	9	NS3	ns3	RB
cord-001835-0s7ok4uw	4278	10	protease	protease	NN
cord-001835-0s7ok4uw	4278	11	variants	variant	NNS
cord-001835-0s7ok4uw	4278	12	,	,	,
cord-001835-0s7ok4uw	4278	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	4278	14	engineered	engineer	VBD
cord-001835-0s7ok4uw	4278	15	NS3	ns3	RB
cord-001835-0s7ok4uw	4278	16	protease	protease	NN
cord-001835-0s7ok4uw	4278	17	domains	domain	NNS
cord-001835-0s7ok4uw	4278	18	that	that	WDT
cord-001835-0s7ok4uw	4278	19	are	be	VBP
cord-001835-0s7ok4uw	4278	20	inhibitable	inhibitable	JJ
cord-001835-0s7ok4uw	4278	21	either	either	RB
cord-001835-0s7ok4uw	4278	22	by	by	IN
cord-001835-0s7ok4uw	4278	23	asunaprevir	asunaprevir	NNP
cord-001835-0s7ok4uw	4278	24	only	only	RB
cord-001835-0s7ok4uw	4278	25	,	,	,
cord-001835-0s7ok4uw	4278	26	or	or	CC
cord-001835-0s7ok4uw	4278	27	by	by	IN
cord-001835-0s7ok4uw	4278	28	telaprevir	telaprevir	NNP
cord-001835-0s7ok4uw	4278	29	only	only	RB
cord-001835-0s7ok4uw	4278	30	.	.	.
cord-001835-0s7ok4uw	4279	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4279	2	found	find	VBD
cord-001835-0s7ok4uw	4279	3	that	that	IN
cord-001835-0s7ok4uw	4279	4	these	these	DT
cord-001835-0s7ok4uw	4279	5	tags	tag	NNS
cord-001835-0s7ok4uw	4279	6	permit	permit	VBP
cord-001835-0s7ok4uw	4279	7	simultaneous	simultaneous	JJ
cord-001835-0s7ok4uw	4279	8	and	and	CC
cord-001835-0s7ok4uw	4279	9	independent	independent	JJ
cord-001835-0s7ok4uw	4279	10	control	control	NN
cord-001835-0s7ok4uw	4279	11	over	over	IN
cord-001835-0s7ok4uw	4279	12	the	the	DT
cord-001835-0s7ok4uw	4279	13	newly	newly	RB
cord-001835-0s7ok4uw	4279	14	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	4279	15	pools	pool	NNS
cord-001835-0s7ok4uw	4279	16	of	of	IN
cord-001835-0s7ok4uw	4279	17	two	two	CD
cord-001835-0s7ok4uw	4279	18	proteins	protein	NNS
cord-001835-0s7ok4uw	4279	19	of	of	IN
cord-001835-0s7ok4uw	4279	20	interest	interest	NN
cord-001835-0s7ok4uw	4279	21	within	within	IN
cord-001835-0s7ok4uw	4279	22	the	the	DT
cord-001835-0s7ok4uw	4279	23	same	same	JJ
cord-001835-0s7ok4uw	4279	24	population	population	NN
cord-001835-0s7ok4uw	4279	25	of	of	IN
cord-001835-0s7ok4uw	4279	26	cells	cell	NNS
cord-001835-0s7ok4uw	4279	27	.	.	.
cord-001835-0s7ok4uw	4280	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4280	2	also	also	RB
cord-001835-0s7ok4uw	4280	3	report	report	VBP
cord-001835-0s7ok4uw	4280	4	the	the	DT
cord-001835-0s7ok4uw	4280	5	development	development	NN
cord-001835-0s7ok4uw	4280	6	of	of	IN
cord-001835-0s7ok4uw	4280	7	transgenic	transgenic	JJ
cord-001835-0s7ok4uw	4280	8	knock	knock	NN
cord-001835-0s7ok4uw	4280	9	-	-	HYPH
cord-001835-0s7ok4uw	4280	10	in	in	RP
cord-001835-0s7ok4uw	4280	11	mouse	mouse	NN
cord-001835-0s7ok4uw	4280	12	strains	strain	NNS
cord-001835-0s7ok4uw	4280	13	incorporating	incorporate	VBG
cord-001835-0s7ok4uw	4280	14	TimeSTAMP	TimeSTAMP	NNP
cord-001835-0s7ok4uw	4280	15	and	and	CC
cord-001835-0s7ok4uw	4280	16	SMASh	SMASh	NNS
cord-001835-0s7ok4uw	4280	17	tags	tag	NNS
cord-001835-0s7ok4uw	4280	18	,	,	,
cord-001835-0s7ok4uw	4280	19	which	which	WDT
cord-001835-0s7ok4uw	4280	20	allow	allow	VBP
cord-001835-0s7ok4uw	4280	21	the	the	DT
cord-001835-0s7ok4uw	4280	22	interrogation	interrogation	NN
cord-001835-0s7ok4uw	4280	23	of	of	IN
cord-001835-0s7ok4uw	4280	24	newly	newly	RB
cord-001835-0s7ok4uw	4280	25	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	4280	26	pools	pool	NNS
cord-001835-0s7ok4uw	4280	27	of	of	IN
cord-001835-0s7ok4uw	4280	28	specific	specific	JJ
cord-001835-0s7ok4uw	4280	29	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	4280	30	synaptic	synaptic	JJ
cord-001835-0s7ok4uw	4280	31	proteins	protein	NNS
cord-001835-0s7ok4uw	4280	32	in	in	IN
cord-001835-0s7ok4uw	4280	33	the	the	DT
cord-001835-0s7ok4uw	4280	34	context	context	NN
cord-001835-0s7ok4uw	4280	35	of	of	IN
cord-001835-0s7ok4uw	4280	36	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4280	37	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	4280	38	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	4280	39	elements	element	NNS
cord-001835-0s7ok4uw	4280	40	,	,	,
cord-001835-0s7ok4uw	4280	41	and	and	CC
cord-001835-0s7ok4uw	4280	42	without	without	IN
cord-001835-0s7ok4uw	4280	43	relying	rely	VBG
cord-001835-0s7ok4uw	4280	44	on	on	IN
cord-001835-0s7ok4uw	4280	45	overexpression	overexpression	NN
cord-001835-0s7ok4uw	4280	46	.	.	.
cord-001835-0s7ok4uw	4281	1	Infectious	infectious	JJ
cord-001835-0s7ok4uw	4281	2	diseases	disease	NNS
cord-001835-0s7ok4uw	4281	3	are	be	VBP
cord-001835-0s7ok4uw	4281	4	often	often	RB
cord-001835-0s7ok4uw	4281	5	diagnosed	diagnose	VBN
cord-001835-0s7ok4uw	4281	6	by	by	IN
cord-001835-0s7ok4uw	4281	7	the	the	DT
cord-001835-0s7ok4uw	4281	8	presence	presence	NN
cord-001835-0s7ok4uw	4281	9	of	of	IN
cord-001835-0s7ok4uw	4281	10	specific	specific	JJ
cord-001835-0s7ok4uw	4281	11	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4281	12	that	that	WDT
cord-001835-0s7ok4uw	4281	13	are	be	VBP
cord-001835-0s7ok4uw	4281	14	produced	produce	VBN
cord-001835-0s7ok4uw	4281	15	in	in	IN
cord-001835-0s7ok4uw	4281	16	response	response	NN
cord-001835-0s7ok4uw	4281	17	to	to	IN
cord-001835-0s7ok4uw	4281	18	the	the	DT
cord-001835-0s7ok4uw	4281	19	invading	invade	VBG
cord-001835-0s7ok4uw	4281	20	pathogen	pathogen	NN
cord-001835-0s7ok4uw	4281	21	.	.	.
cord-001835-0s7ok4uw	4282	1	One	one	CD
cord-001835-0s7ok4uw	4282	2	example	example	NN
cord-001835-0s7ok4uw	4282	3	are	be	VBP
cord-001835-0s7ok4uw	4282	4	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4282	5	that	that	WDT
cord-001835-0s7ok4uw	4282	6	are	be	VBP
cord-001835-0s7ok4uw	4282	7	present	present	JJ
cord-001835-0s7ok4uw	4282	8	in	in	IN
cord-001835-0s7ok4uw	4282	9	patient	patient	JJ
cord-001835-0s7ok4uw	4282	10	blood	blood	NN
cord-001835-0s7ok4uw	4282	11	after	after	IN
cord-001835-0s7ok4uw	4282	12	infection	infection	NN
cord-001835-0s7ok4uw	4282	13	with	with	IN
cord-001835-0s7ok4uw	4282	14	the	the	DT
cord-001835-0s7ok4uw	4282	15	Dengue	Dengue	NNP
cord-001835-0s7ok4uw	4282	16	virus	virus	NN
cord-001835-0s7ok4uw	4282	17	serotype	serotype	NN
cord-001835-0s7ok4uw	4282	18	1	1	CD
cord-001835-0s7ok4uw	4282	19	and	and	CC
cord-001835-0s7ok4uw	4282	20	that	that	WDT
cord-001835-0s7ok4uw	4282	21	are	be	VBP
cord-001835-0s7ok4uw	4282	22	directed	direct	VBN
cord-001835-0s7ok4uw	4282	23	against	against	IN
cord-001835-0s7ok4uw	4282	24	an	an	DT
cord-001835-0s7ok4uw	4282	25	epitope	epitope	NN
cord-001835-0s7ok4uw	4282	26	on	on	IN
cord-001835-0s7ok4uw	4282	27	the	the	DT
cord-001835-0s7ok4uw	4282	28	virus	virus	NN
cord-001835-0s7ok4uw	4282	29	'	'	POS
cord-001835-0s7ok4uw	4282	30	nonstructural	nonstructural	JJ
cord-001835-0s7ok4uw	4282	31	protein	protein	NN
cord-001835-0s7ok4uw	4282	32	1	1	CD
cord-001835-0s7ok4uw	4282	33	(	(	-LRB-
cord-001835-0s7ok4uw	4282	34	NS-1	NS-1	NNP
cord-001835-0s7ok4uw	4282	35	)	)	-RRB-
cord-001835-0s7ok4uw	4282	36	.	.	.
cord-001835-0s7ok4uw	4283	1	Traditional	traditional	JJ
cord-001835-0s7ok4uw	4283	2	antibody	antibody	NN
cord-001835-0s7ok4uw	4283	3	diagnosis	diagnosis	NN
cord-001835-0s7ok4uw	4283	4	relies	rely	VBZ
cord-001835-0s7ok4uw	4283	5	on	on	IN
cord-001835-0s7ok4uw	4283	6	time	time	NN
cord-001835-0s7ok4uw	4283	7	-	-	HYPH
cord-001835-0s7ok4uw	4283	8	consuming	consume	VBG
cord-001835-0s7ok4uw	4283	9	multi	multi	JJ
cord-001835-0s7ok4uw	4283	10	-	-	JJ
cord-001835-0s7ok4uw	4283	11	step	step	JJ
cord-001835-0s7ok4uw	4283	12	assays	assay	NNS
cord-001835-0s7ok4uw	4283	13	that	that	WDT
cord-001835-0s7ok4uw	4283	14	require	require	VBP
cord-001835-0s7ok4uw	4283	15	sophisticated	sophisticated	JJ
cord-001835-0s7ok4uw	4283	16	equipment	equipment	NN
cord-001835-0s7ok4uw	4283	17	in	in	IN
cord-001835-0s7ok4uw	4283	18	a	a	DT
cord-001835-0s7ok4uw	4283	19	laboratory	laboratory	NN
cord-001835-0s7ok4uw	4283	20	environment	environment	NN
cord-001835-0s7ok4uw	4283	21	.	.	.
cord-001835-0s7ok4uw	4284	1	A	a	DT
cord-001835-0s7ok4uw	4284	2	promising	promising	JJ
cord-001835-0s7ok4uw	4284	3	alternative	alternative	NN
cord-001835-0s7ok4uw	4284	4	are	be	VBP
cord-001835-0s7ok4uw	4284	5	protein	protein	NN
cord-001835-0s7ok4uw	4284	6	switches	switch	NNS
cord-001835-0s7ok4uw	4284	7	that	that	WDT
cord-001835-0s7ok4uw	4284	8	are	be	VBP
cord-001835-0s7ok4uw	4284	9	based	base	VBN
cord-001835-0s7ok4uw	4284	10	on	on	IN
cord-001835-0s7ok4uw	4284	11	bioluminescence	bioluminescence	NN
cord-001835-0s7ok4uw	4284	12	resonance	resonance	NN
cord-001835-0s7ok4uw	4284	13	energy	energy	NN
cord-001835-0s7ok4uw	4284	14	transfer	transfer	NN
cord-001835-0s7ok4uw	4284	15	(	(	-LRB-
cord-001835-0s7ok4uw	4284	16	BRET	BRET	NNP
cord-001835-0s7ok4uw	4284	17	)	)	-RRB-
cord-001835-0s7ok4uw	4284	18	.	.	.
cord-001835-0s7ok4uw	4285	1	These	these	DT
cord-001835-0s7ok4uw	4285	2	switches	switch	NNS
cord-001835-0s7ok4uw	4285	3	comprise	comprise	VBP
cord-001835-0s7ok4uw	4285	4	a	a	DT
cord-001835-0s7ok4uw	4285	5	luciferase	luciferase	NN
cord-001835-0s7ok4uw	4285	6	(	(	-LRB-
cord-001835-0s7ok4uw	4285	7	NanoLuc	NanoLuc	NNP
cord-001835-0s7ok4uw	4285	8	)	)	-RRB-
cord-001835-0s7ok4uw	4285	9	and	and	CC
cord-001835-0s7ok4uw	4285	10	a	a	DT
cord-001835-0s7ok4uw	4285	11	green	green	JJ
cord-001835-0s7ok4uw	4285	12	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	4285	13	protein	protein	NN
cord-001835-0s7ok4uw	4285	14	(	(	-LRB-
cord-001835-0s7ok4uw	4285	15	mNeonGreen	mNeonGreen	NNP
cord-001835-0s7ok4uw	4285	16	)	)	-RRB-
cord-001835-0s7ok4uw	4285	17	,	,	,
cord-001835-0s7ok4uw	4285	18	which	which	WDT
cord-001835-0s7ok4uw	4285	19	are	be	VBP
cord-001835-0s7ok4uw	4285	20	connected	connect	VBN
cord-001835-0s7ok4uw	4285	21	via	via	IN
cord-001835-0s7ok4uw	4285	22	a	a	DT
cord-001835-0s7ok4uw	4285	23	semiflexible	semiflexible	JJ
cord-001835-0s7ok4uw	4285	24	linker	linker	NN
cord-001835-0s7ok4uw	4285	25	.	.	.
cord-001835-0s7ok4uw	4286	1	The	the	DT
cord-001835-0s7ok4uw	4286	2	linker	linker	NN
cord-001835-0s7ok4uw	4286	3	contains	contain	VBZ
cord-001835-0s7ok4uw	4286	4	two	two	CD
cord-001835-0s7ok4uw	4286	5	epitope	epitope	NN
cord-001835-0s7ok4uw	4286	6	sequences	sequence	NNS
cord-001835-0s7ok4uw	4286	7	of	of	IN
cord-001835-0s7ok4uw	4286	8	NS-1	NS-1	NNP
cord-001835-0s7ok4uw	4286	9	to	to	TO
cord-001835-0s7ok4uw	4286	10	which	which	WDT
cord-001835-0s7ok4uw	4286	11	the	the	DT
cord-001835-0s7ok4uw	4286	12	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4286	13	bind	bind	VBP
cord-001835-0s7ok4uw	4286	14	specifically	specifically	RB
cord-001835-0s7ok4uw	4286	15	.	.	.
cord-001835-0s7ok4uw	4287	1	If	if	IN
cord-001835-0s7ok4uw	4287	2	no	no	DT
cord-001835-0s7ok4uw	4287	3	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4287	4	are	be	VBP
cord-001835-0s7ok4uw	4287	5	present	present	JJ
cord-001835-0s7ok4uw	4287	6	NanoLuc	NanoLuc	NNP
cord-001835-0s7ok4uw	4287	7	and	and	CC
cord-001835-0s7ok4uw	4287	8	mNeonGreen	mNeonGreen	NNS
cord-001835-0s7ok4uw	4287	9	are	be	VBP
cord-001835-0s7ok4uw	4287	10	held	hold	VBN
cord-001835-0s7ok4uw	4287	11	in	in	IN
cord-001835-0s7ok4uw	4287	12	close	close	JJ
cord-001835-0s7ok4uw	4287	13	proximity	proximity	NN
cord-001835-0s7ok4uw	4287	14	via	via	IN
cord-001835-0s7ok4uw	4287	15	two	two	CD
cord-001835-0s7ok4uw	4287	16	helper	helper	NN
cord-001835-0s7ok4uw	4287	17	domains	domain	NNS
cord-001835-0s7ok4uw	4287	18	and	and	CC
cord-001835-0s7ok4uw	4287	19	BRET	BRET	NNP
cord-001835-0s7ok4uw	4287	20	can	can	MD
cord-001835-0s7ok4uw	4287	21	occur	occur	VB
cord-001835-0s7ok4uw	4287	22	;	;	:
cord-001835-0s7ok4uw	4287	23	thus	thus	RB
cord-001835-0s7ok4uw	4287	24	green	green	JJ
cord-001835-0s7ok4uw	4287	25	light	light	NN
cord-001835-0s7ok4uw	4287	26	originating	originate	VBG
cord-001835-0s7ok4uw	4287	27	from	from	IN
cord-001835-0s7ok4uw	4287	28	mNeonGreen	mneongreen	JJ
cord-001835-0s7ok4uw	4287	29	is	be	VBZ
cord-001835-0s7ok4uw	4287	30	visible	visible	JJ
cord-001835-0s7ok4uw	4287	31	.	.	.
cord-001835-0s7ok4uw	4288	1	If	if	IN
cord-001835-0s7ok4uw	4288	2	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4288	3	are	be	VBP
cord-001835-0s7ok4uw	4288	4	present	present	JJ
cord-001835-0s7ok4uw	4288	5	,	,	,
cord-001835-0s7ok4uw	4288	6	they	-PRON-	PRP
cord-001835-0s7ok4uw	4288	7	bind	bind	VBP
cord-001835-0s7ok4uw	4288	8	to	to	IN
cord-001835-0s7ok4uw	4288	9	the	the	DT
cord-001835-0s7ok4uw	4288	10	specific	specific	JJ
cord-001835-0s7ok4uw	4288	11	epitopes	epitope	NNS
cord-001835-0s7ok4uw	4288	12	in	in	IN
cord-001835-0s7ok4uw	4288	13	the	the	DT
cord-001835-0s7ok4uw	4288	14	linker	linker	NN
cord-001835-0s7ok4uw	4288	15	of	of	IN
cord-001835-0s7ok4uw	4288	16	the	the	DT
cord-001835-0s7ok4uw	4288	17	switch	switch	NN
cord-001835-0s7ok4uw	4288	18	and	and	CC
cord-001835-0s7ok4uw	4288	19	cause	cause	VB
cord-001835-0s7ok4uw	4288	20	stretching	stretching	NN
cord-001835-0s7ok4uw	4288	21	of	of	IN
cord-001835-0s7ok4uw	4288	22	the	the	DT
cord-001835-0s7ok4uw	4288	23	linker	linker	NN
cord-001835-0s7ok4uw	4288	24	and	and	CC
cord-001835-0s7ok4uw	4288	25	therewith	therewith	RB
cord-001835-0s7ok4uw	4288	26	break	break	VB
cord-001835-0s7ok4uw	4288	27	the	the	DT
cord-001835-0s7ok4uw	4288	28	interaction	interaction	NN
cord-001835-0s7ok4uw	4288	29	of	of	IN
cord-001835-0s7ok4uw	4288	30	the	the	DT
cord-001835-0s7ok4uw	4288	31	helper	helper	NN
cord-001835-0s7ok4uw	4288	32	domains	domain	NNS
cord-001835-0s7ok4uw	4288	33	.	.	.
cord-001835-0s7ok4uw	4289	1	As	as	IN
cord-001835-0s7ok4uw	4289	2	a	a	DT
cord-001835-0s7ok4uw	4289	3	result	result	NN
cord-001835-0s7ok4uw	4289	4	,	,	,
cord-001835-0s7ok4uw	4289	5	NanoLuc	NanoLuc	NNP
cord-001835-0s7ok4uw	4289	6	and	and	CC
cord-001835-0s7ok4uw	4289	7	mNeonGreen	mNeonGreen	NNS
cord-001835-0s7ok4uw	4289	8	are	be	VBP
cord-001835-0s7ok4uw	4289	9	separated	separate	VBN
cord-001835-0s7ok4uw	4289	10	in	in	IN
cord-001835-0s7ok4uw	4289	11	such	such	PDT
cord-001835-0s7ok4uw	4289	12	a	a	DT
cord-001835-0s7ok4uw	4289	13	way	way	NN
cord-001835-0s7ok4uw	4289	14	that	that	WDT
cord-001835-0s7ok4uw	4289	15	BRET	BRET	NNP
cord-001835-0s7ok4uw	4289	16	can	can	MD
cord-001835-0s7ok4uw	4289	17	not	not	RB
cord-001835-0s7ok4uw	4289	18	occur	occur	VB
cord-001835-0s7ok4uw	4289	19	anymore	anymore	RB
cord-001835-0s7ok4uw	4289	20	;	;	:
cord-001835-0s7ok4uw	4289	21	thus	thus	RB
cord-001835-0s7ok4uw	4289	22	only	only	RB
cord-001835-0s7ok4uw	4289	23	blue	blue	JJ
cord-001835-0s7ok4uw	4289	24	light	light	NN
cord-001835-0s7ok4uw	4289	25	originating	originate	VBG
cord-001835-0s7ok4uw	4289	26	from	from	IN
cord-001835-0s7ok4uw	4289	27	Nano	Nano	NNP
cord-001835-0s7ok4uw	4289	28	-	-	HYPH
cord-001835-0s7ok4uw	4289	29	Luc	Luc	NNP
cord-001835-0s7ok4uw	4289	30	remains	remain	VBZ
cord-001835-0s7ok4uw	4289	31	visible	visible	JJ
cord-001835-0s7ok4uw	4289	32	.	.	.
cord-001835-0s7ok4uw	4290	1	Using	use	VBG
cord-001835-0s7ok4uw	4290	2	this	this	DT
cord-001835-0s7ok4uw	4290	3	principle	principle	NN
cord-001835-0s7ok4uw	4290	4	,	,	,
cord-001835-0s7ok4uw	4290	5	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	4290	6	anti	anti	JJ
cord-001835-0s7ok4uw	4290	7	-	-	JJ
cord-001835-0s7ok4uw	4290	8	NS-1	ns-1	JJ
cord-001835-0s7ok4uw	4290	9	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4290	10	were	be	VBD
cord-001835-0s7ok4uw	4290	11	detectable	detectable	JJ
cord-001835-0s7ok4uw	4290	12	in	in	IN
cord-001835-0s7ok4uw	4290	13	a	a	DT
cord-001835-0s7ok4uw	4290	14	controlled	control	VBN
cord-001835-0s7ok4uw	4290	15	buffer	buffer	NN
cord-001835-0s7ok4uw	4290	16	system	system	NN
cord-001835-0s7ok4uw	4290	17	and	and	CC
cord-001835-0s7ok4uw	4290	18	in	in	IN
cord-001835-0s7ok4uw	4290	19	spiked	spiked	JJ
cord-001835-0s7ok4uw	4290	20	plasma	plasma	NN
cord-001835-0s7ok4uw	4290	21	samples	sample	NNS
cord-001835-0s7ok4uw	4290	22	.	.	.
cord-001835-0s7ok4uw	4291	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	4291	2	,	,	,
cord-001835-0s7ok4uw	4291	3	the	the	DT
cord-001835-0s7ok4uw	4291	4	developed	develop	VBN
cord-001835-0s7ok4uw	4291	5	antibody	antibody	NN
cord-001835-0s7ok4uw	4291	6	switch	switch	NN
cord-001835-0s7ok4uw	4291	7	was	be	VBD
cord-001835-0s7ok4uw	4291	8	applied	apply	VBN
cord-001835-0s7ok4uw	4291	9	to	to	IN
cord-001835-0s7ok4uw	4291	10	plasma	plasma	NN
cord-001835-0s7ok4uw	4291	11	samples	sample	NNS
cord-001835-0s7ok4uw	4291	12	of	of	IN
cord-001835-0s7ok4uw	4291	13	macaques	macaque	NNS
cord-001835-0s7ok4uw	4291	14	after	after	IN
cord-001835-0s7ok4uw	4291	15	a	a	DT
cord-001835-0s7ok4uw	4291	16	primary	primary	JJ
cord-001835-0s7ok4uw	4291	17	infection	infection	NN
cord-001835-0s7ok4uw	4291	18	with	with	IN
cord-001835-0s7ok4uw	4291	19	Dengue	Dengue	NNP
cord-001835-0s7ok4uw	4291	20	virus	virus	NN
cord-001835-0s7ok4uw	4291	21	serotype	serotype	NN
cord-001835-0s7ok4uw	4291	22	1	1	CD
cord-001835-0s7ok4uw	4291	23	.	.	.
cord-001835-0s7ok4uw	4292	1	Signal	signal	NN
cord-001835-0s7ok4uw	4292	2	readout	readout	NN
cord-001835-0s7ok4uw	4292	3	was	be	VBD
cord-001835-0s7ok4uw	4292	4	possible	possible	JJ
cord-001835-0s7ok4uw	4292	5	using	use	VBG
cord-001835-0s7ok4uw	4292	6	a	a	DT
cord-001835-0s7ok4uw	4292	7	laboratory	laboratory	NN
cord-001835-0s7ok4uw	4292	8	-	-	HYPH
cord-001835-0s7ok4uw	4292	9	based	base	VBN
cord-001835-0s7ok4uw	4292	10	plate	plate	NN
cord-001835-0s7ok4uw	4292	11	reader	reader	NN
cord-001835-0s7ok4uw	4292	12	as	as	RB
cord-001835-0s7ok4uw	4292	13	well	well	RB
cord-001835-0s7ok4uw	4292	14	as	as	IN
cord-001835-0s7ok4uw	4292	15	the	the	DT
cord-001835-0s7ok4uw	4292	16	camera	camera	NN
cord-001835-0s7ok4uw	4292	17	of	of	IN
cord-001835-0s7ok4uw	4292	18	a	a	DT
cord-001835-0s7ok4uw	4292	19	standard	standard	JJ
cord-001835-0s7ok4uw	4292	20	smartphone	smartphone	NN
cord-001835-0s7ok4uw	4292	21	.	.	.
cord-001835-0s7ok4uw	4293	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4293	2	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	4293	3	that	that	IN
cord-001835-0s7ok4uw	4293	4	this	this	DT
cord-001835-0s7ok4uw	4293	5	BRET	BRET	NNP
cord-001835-0s7ok4uw	4293	6	-	-	HYPH
cord-001835-0s7ok4uw	4293	7	based	base	VBN
cord-001835-0s7ok4uw	4293	8	protein	protein	NN
cord-001835-0s7ok4uw	4293	9	switch	switch	NN
cord-001835-0s7ok4uw	4293	10	can	can	MD
cord-001835-0s7ok4uw	4293	11	quickly	quickly	RB
cord-001835-0s7ok4uw	4293	12	detect	detect	VB
cord-001835-0s7ok4uw	4293	13	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4293	14	in	in	IN
cord-001835-0s7ok4uw	4293	15	solution	solution	NN
cord-001835-0s7ok4uw	4293	16	in	in	IN
cord-001835-0s7ok4uw	4293	17	a	a	DT
cord-001835-0s7ok4uw	4293	18	single	single	JJ
cord-001835-0s7ok4uw	4293	19	-	-	HYPH
cord-001835-0s7ok4uw	4293	20	step	step	NN
cord-001835-0s7ok4uw	4293	21	assay	assay	NN
cord-001835-0s7ok4uw	4293	22	format	format	NN
cord-001835-0s7ok4uw	4293	23	using	use	VBG
cord-001835-0s7ok4uw	4293	24	simple	simple	JJ
cord-001835-0s7ok4uw	4293	25	equipment	equipment	NN
cord-001835-0s7ok4uw	4293	26	for	for	IN
cord-001835-0s7ok4uw	4293	27	signal	signal	NN
cord-001835-0s7ok4uw	4293	28	readout	readout	NN
cord-001835-0s7ok4uw	4293	29	,	,	,
cord-001835-0s7ok4uw	4293	30	such	such	JJ
cord-001835-0s7ok4uw	4293	31	as	as	IN
cord-001835-0s7ok4uw	4293	32	a	a	DT
cord-001835-0s7ok4uw	4293	33	standard	standard	JJ
cord-001835-0s7ok4uw	4293	34	smartphone	smartphone	NN
cord-001835-0s7ok4uw	4293	35	.	.	.
cord-001835-0s7ok4uw	4294	1	This	this	DT
cord-001835-0s7ok4uw	4294	2	simplified	simplified	JJ
cord-001835-0s7ok4uw	4294	3	antibody	antibody	NN
cord-001835-0s7ok4uw	4294	4	detection	detection	NN
cord-001835-0s7ok4uw	4294	5	platform	platform	NN
cord-001835-0s7ok4uw	4294	6	has	have	VBZ
cord-001835-0s7ok4uw	4294	7	the	the	DT
cord-001835-0s7ok4uw	4294	8	potential	potential	NN
cord-001835-0s7ok4uw	4294	9	to	to	TO
cord-001835-0s7ok4uw	4294	10	be	be	VB
cord-001835-0s7ok4uw	4294	11	carried	carry	VBN
cord-001835-0s7ok4uw	4294	12	out	out	RP
cord-001835-0s7ok4uw	4294	13	outside	outside	RB
cord-001835-0s7ok4uw	4294	14	of	of	IN
cord-001835-0s7ok4uw	4294	15	a	a	DT
cord-001835-0s7ok4uw	4294	16	laboratory	laboratory	NN
cord-001835-0s7ok4uw	4294	17	,	,	,
cord-001835-0s7ok4uw	4294	18	thus	thus	RB
cord-001835-0s7ok4uw	4294	19	in	in	IN
cord-001835-0s7ok4uw	4294	20	areas	area	NNS
cord-001835-0s7ok4uw	4294	21	with	with	IN
cord-001835-0s7ok4uw	4294	22	limited	limited	JJ
cord-001835-0s7ok4uw	4294	23	laboratory	laboratory	NN
cord-001835-0s7ok4uw	4294	24	infrastructure	infrastructure	NN
cord-001835-0s7ok4uw	4294	25	and	and	CC
cord-001835-0s7ok4uw	4294	26	a	a	DT
cord-001835-0s7ok4uw	4294	27	high	high	JJ
cord-001835-0s7ok4uw	4294	28	number	number	NN
cord-001835-0s7ok4uw	4294	29	of	of	IN
cord-001835-0s7ok4uw	4294	30	diverse	diverse	JJ
cord-001835-0s7ok4uw	4294	31	infectious	infectious	JJ
cord-001835-0s7ok4uw	4294	32	diseases	disease	NNS
cord-001835-0s7ok4uw	4294	33	.	.	.
cord-001835-0s7ok4uw	4295	1	Proteins	protein	NNS
cord-001835-0s7ok4uw	4295	2	expressed	express	VBD
cord-001835-0s7ok4uw	4295	3	from	from	IN
cord-001835-0s7ok4uw	4295	4	more	more	JJR
cord-001835-0s7ok4uw	4295	5	than	than	IN
cord-001835-0s7ok4uw	4295	6	two	two	CD
cord-001835-0s7ok4uw	4295	7	-	-	HYPH
cord-001835-0s7ok4uw	4295	8	thirds	third	NNS
cord-001835-0s7ok4uw	4295	9	of	of	IN
cord-001835-0s7ok4uw	4295	10	the	the	DT
cord-001835-0s7ok4uw	4295	11	human	human	JJ
cord-001835-0s7ok4uw	4295	12	genome	genome	NN
cord-001835-0s7ok4uw	4295	13	reside	reside	VBP
cord-001835-0s7ok4uw	4295	14	within	within	IN
cord-001835-0s7ok4uw	4295	15	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	4295	16	compartments	compartment	NNS
cord-001835-0s7ok4uw	4295	17	.	.	.
cord-001835-0s7ok4uw	4296	1	Of	of	IN
cord-001835-0s7ok4uw	4296	2	these	these	DT
cord-001835-0s7ok4uw	4296	3	proteins	protein	NNS
cord-001835-0s7ok4uw	4296	4	many	many	JJ
cord-001835-0s7ok4uw	4296	5	are	be	VBP
cord-001835-0s7ok4uw	4296	6	important	important	JJ
cord-001835-0s7ok4uw	4296	7	disease	disease	NN
cord-001835-0s7ok4uw	4296	8	-	-	HYPH
cord-001835-0s7ok4uw	4296	9	related	relate	VBN
cord-001835-0s7ok4uw	4296	10	targets	target	NNS
cord-001835-0s7ok4uw	4296	11	such	such	JJ
cord-001835-0s7ok4uw	4296	12	as	as	IN
cord-001835-0s7ok4uw	4296	13	KRas	KRas	NNP
cord-001835-0s7ok4uw	4296	14	and	and	CC
cord-001835-0s7ok4uw	4296	15	c	c	NNP
cord-001835-0s7ok4uw	4296	16	-	-	HYPH
cord-001835-0s7ok4uw	4296	17	Myc	Myc	NNP
cord-001835-0s7ok4uw	4296	18	which	which	WDT
cord-001835-0s7ok4uw	4296	19	can	can	MD
cord-001835-0s7ok4uw	4296	20	not	not	RB
cord-001835-0s7ok4uw	4296	21	be	be	VB
cord-001835-0s7ok4uw	4296	22	easily	easily	RB
cord-001835-0s7ok4uw	4296	23	addressed	address	VBN
cord-001835-0s7ok4uw	4296	24	by	by	IN
cord-001835-0s7ok4uw	4296	25	conventional	conventional	JJ
cord-001835-0s7ok4uw	4296	26	small	small	JJ
cord-001835-0s7ok4uw	4296	27	molecule	molecule	NN
cord-001835-0s7ok4uw	4296	28	approaches	approach	NNS
cord-001835-0s7ok4uw	4296	29	.	.	.
cord-001835-0s7ok4uw	4297	1	Some	some	DT
cord-001835-0s7ok4uw	4297	2	of	of	IN
cord-001835-0s7ok4uw	4297	3	the	the	DT
cord-001835-0s7ok4uw	4297	4	weaknesses	weakness	NNS
cord-001835-0s7ok4uw	4297	5	of	of	IN
cord-001835-0s7ok4uw	4297	6	small	small	JJ
cord-001835-0s7ok4uw	4297	7	molecules	molecule	NNS
cord-001835-0s7ok4uw	4297	8	can	can	MD
cord-001835-0s7ok4uw	4297	9	be	be	VB
cord-001835-0s7ok4uw	4297	10	addressed	address	VBN
cord-001835-0s7ok4uw	4297	11	by	by	IN
cord-001835-0s7ok4uw	4297	12	biologic	biologic	JJ
cord-001835-0s7ok4uw	4297	13	drugs	drug	NNS
cord-001835-0s7ok4uw	4297	14	,	,	,
cord-001835-0s7ok4uw	4297	15	for	for	IN
cord-001835-0s7ok4uw	4297	16	example	example	NN
cord-001835-0s7ok4uw	4297	17	high	high	JJ
cord-001835-0s7ok4uw	4297	18	target	target	NN
cord-001835-0s7ok4uw	4297	19	specificity	specificity	NN
cord-001835-0s7ok4uw	4297	20	and	and	CC
cord-001835-0s7ok4uw	4297	21	inhibition	inhibition	NN
cord-001835-0s7ok4uw	4297	22	of	of	IN
cord-001835-0s7ok4uw	4297	23	protein	protein	NN
cord-001835-0s7ok4uw	4297	24	-	-	HYPH
cord-001835-0s7ok4uw	4297	25	protein	protein	NN
cord-001835-0s7ok4uw	4297	26	interactions	interaction	NNS
cord-001835-0s7ok4uw	4297	27	.	.	.
cord-001835-0s7ok4uw	4298	1	The	the	DT
cord-001835-0s7ok4uw	4298	2	challenge	challenge	NN
cord-001835-0s7ok4uw	4298	3	for	for	IN
cord-001835-0s7ok4uw	4298	4	biologics	biologic	NNS
cord-001835-0s7ok4uw	4298	5	is	be	VBZ
cord-001835-0s7ok4uw	4298	6	how	how	WRB
cord-001835-0s7ok4uw	4298	7	to	to	TO
cord-001835-0s7ok4uw	4298	8	engineer	engineer	VB
cord-001835-0s7ok4uw	4298	9	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	4298	10	proteins	protein	NNS
cord-001835-0s7ok4uw	4298	11	to	to	TO
cord-001835-0s7ok4uw	4298	12	access	access	VB
cord-001835-0s7ok4uw	4298	13	the	the	DT
cord-001835-0s7ok4uw	4298	14	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	4298	15	space	space	NN
cord-001835-0s7ok4uw	4298	16	.	.	.
cord-001835-0s7ok4uw	4299	1	One	one	CD
cord-001835-0s7ok4uw	4299	2	strategy	strategy	NN
cord-001835-0s7ok4uw	4299	3	is	be	VBZ
cord-001835-0s7ok4uw	4299	4	to	to	TO
cord-001835-0s7ok4uw	4299	5	use	use	VB
cord-001835-0s7ok4uw	4299	6	systems	system	NNS
cord-001835-0s7ok4uw	4299	7	evolved	evolve	VBN
cord-001835-0s7ok4uw	4299	8	by	by	IN
cord-001835-0s7ok4uw	4299	9	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	4299	10	and	and	CC
cord-001835-0s7ok4uw	4299	11	viruses	virus	NNS
cord-001835-0s7ok4uw	4299	12	to	to	TO
cord-001835-0s7ok4uw	4299	13	deliver	deliver	VB
cord-001835-0s7ok4uw	4299	14	material	material	NN
cord-001835-0s7ok4uw	4299	15	inside	inside	IN
cord-001835-0s7ok4uw	4299	16	the	the	DT
cord-001835-0s7ok4uw	4299	17	cells	cell	NNS
cord-001835-0s7ok4uw	4299	18	.	.	.
cord-001835-0s7ok4uw	4300	1	An	an	DT
cord-001835-0s7ok4uw	4300	2	example	example	NN
cord-001835-0s7ok4uw	4300	3	of	of	IN
cord-001835-0s7ok4uw	4300	4	such	such	JJ
cord-001835-0s7ok4uw	4300	5	pathway	pathway	NN
cord-001835-0s7ok4uw	4300	6	is	be	VBZ
cord-001835-0s7ok4uw	4300	7	used	use	VBN
cord-001835-0s7ok4uw	4300	8	by	by	IN
cord-001835-0s7ok4uw	4300	9	Pseudomonas	Pseudomonas	NNP
cord-001835-0s7ok4uw	4300	10	Exotoxin	Exotoxin	NNP
cord-001835-0s7ok4uw	4300	11	A	A	NNP
cord-001835-0s7ok4uw	4300	12	(	(	-LRB-
cord-001835-0s7ok4uw	4300	13	PE	pe	NN
cord-001835-0s7ok4uw	4300	14	)	)	-RRB-
cord-001835-0s7ok4uw	4300	15	.	.	.
cord-001835-0s7ok4uw	4301	1	The	the	DT
cord-001835-0s7ok4uw	4301	2	modularity	modularity	NN
cord-001835-0s7ok4uw	4301	3	of	of	IN
cord-001835-0s7ok4uw	4301	4	PE	PE	NNP
cord-001835-0s7ok4uw	4301	5	allows	allow	VBZ
cord-001835-0s7ok4uw	4301	6	the	the	DT
cord-001835-0s7ok4uw	4301	7	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	4301	8	domain	domain	NN
cord-001835-0s7ok4uw	4301	9	to	to	TO
cord-001835-0s7ok4uw	4301	10	be	be	VB
cord-001835-0s7ok4uw	4301	11	replaced	replace	VBN
cord-001835-0s7ok4uw	4301	12	with	with	IN
cord-001835-0s7ok4uw	4301	13	a	a	DT
cord-001835-0s7ok4uw	4301	14	biologic	biologic	JJ
cord-001835-0s7ok4uw	4301	15	payload	payload	NN
cord-001835-0s7ok4uw	4301	16	against	against	IN
cord-001835-0s7ok4uw	4301	17	desired	desire	VBN
cord-001835-0s7ok4uw	4301	18	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	4301	19	target	target	NN
cord-001835-0s7ok4uw	4301	20	.	.	.
cord-001835-0s7ok4uw	4302	1	An	an	DT
cord-001835-0s7ok4uw	4302	2	additional	additional	JJ
cord-001835-0s7ok4uw	4302	3	benefit	benefit	NN
cord-001835-0s7ok4uw	4302	4	of	of	IN
cord-001835-0s7ok4uw	4302	5	PE	pe	NN
cord-001835-0s7ok4uw	4302	6	-	-	HYPH
cord-001835-0s7ok4uw	4302	7	based	base	VBN
cord-001835-0s7ok4uw	4302	8	delivery	delivery	NN
cord-001835-0s7ok4uw	4302	9	is	be	VBZ
cord-001835-0s7ok4uw	4302	10	a	a	DT
cord-001835-0s7ok4uw	4302	11	possibility	possibility	NN
cord-001835-0s7ok4uw	4302	12	of	of	IN
cord-001835-0s7ok4uw	4302	13	targeting	target	VBG
cord-001835-0s7ok4uw	4302	14	the	the	DT
cord-001835-0s7ok4uw	4302	15	drugs	drug	NNS
cord-001835-0s7ok4uw	4302	16	only	only	RB
cord-001835-0s7ok4uw	4302	17	to	to	IN
cord-001835-0s7ok4uw	4302	18	relevant	relevant	JJ
cord-001835-0s7ok4uw	4302	19	cells	cell	NNS
cord-001835-0s7ok4uw	4302	20	in	in	IN
cord-001835-0s7ok4uw	4302	21	the	the	DT
cord-001835-0s7ok4uw	4302	22	body	body	NN
cord-001835-0s7ok4uw	4302	23	by	by	IN
cord-001835-0s7ok4uw	4302	24	modifying	modify	VBG
cord-001835-0s7ok4uw	4302	25	the	the	DT
cord-001835-0s7ok4uw	4302	26	cell	cell	NN
cord-001835-0s7ok4uw	4302	27	-	-	HYPH
cord-001835-0s7ok4uw	4302	28	targeting	target	VBG
cord-001835-0s7ok4uw	4302	29	domain	domain	NN
cord-001835-0s7ok4uw	4302	30	of	of	IN
cord-001835-0s7ok4uw	4302	31	the	the	DT
cord-001835-0s7ok4uw	4302	32	PE	PE	NNP
cord-001835-0s7ok4uw	4302	33	.	.	.
cord-001835-0s7ok4uw	4303	1	The	the	DT
cord-001835-0s7ok4uw	4303	2	aim	aim	NN
cord-001835-0s7ok4uw	4303	3	of	of	IN
cord-001835-0s7ok4uw	4303	4	this	this	DT
cord-001835-0s7ok4uw	4303	5	project	project	NN
cord-001835-0s7ok4uw	4303	6	is	be	VBZ
cord-001835-0s7ok4uw	4303	7	to	to	TO
cord-001835-0s7ok4uw	4303	8	deliver	deliver	VB
cord-001835-0s7ok4uw	4303	9	functional	functional	JJ
cord-001835-0s7ok4uw	4303	10	payloads	payload	NNS
cord-001835-0s7ok4uw	4303	11	against	against	IN
cord-001835-0s7ok4uw	4303	12	K	K	NNP
cord-001835-0s7ok4uw	4303	13	-	-	HYPH
cord-001835-0s7ok4uw	4303	14	Ras	Ras	NNP
cord-001835-0s7ok4uw	4303	15	and	and	CC
cord-001835-0s7ok4uw	4303	16	c	c	NNP
cord-001835-0s7ok4uw	4303	17	-	-	:
cord-001835-0s7ok4uw	4303	18	Myc	Myc	NNP
cord-001835-0s7ok4uw	4303	19	into	into	IN
cord-001835-0s7ok4uw	4303	20	the	the	DT
cord-001835-0s7ok4uw	4303	21	cell	cell	NN
cord-001835-0s7ok4uw	4303	22	using	use	VBG
cord-001835-0s7ok4uw	4303	23	a	a	DT
cord-001835-0s7ok4uw	4303	24	Pseudomonas	Pseudomonas	NNP
cord-001835-0s7ok4uw	4303	25	Exotoxin	Exotoxin	NNP
cord-001835-0s7ok4uw	4303	26	A	a	DT
cord-001835-0s7ok4uw	4303	27	translocation	translocation	NN
cord-001835-0s7ok4uw	4303	28	domain	domain	NN
cord-001835-0s7ok4uw	4303	29	.	.	.
cord-001835-0s7ok4uw	4304	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4304	2	used	use	VBD
cord-001835-0s7ok4uw	4304	3	phage	phage	NN
cord-001835-0s7ok4uw	4304	4	and	and	CC
cord-001835-0s7ok4uw	4304	5	ribosome	ribosome	NN
cord-001835-0s7ok4uw	4304	6	display	display	NN
cord-001835-0s7ok4uw	4304	7	to	to	TO
cord-001835-0s7ok4uw	4304	8	select	select	VB
cord-001835-0s7ok4uw	4304	9	antibody	antibody	NN
cord-001835-0s7ok4uw	4304	10	mimetics	mimetic	NNS
cord-001835-0s7ok4uw	4304	11	that	that	WDT
cord-001835-0s7ok4uw	4304	12	bind	bind	VBP
cord-001835-0s7ok4uw	4304	13	K	K	NNP
cord-001835-0s7ok4uw	4304	14	-	-	HYPH
cord-001835-0s7ok4uw	4304	15	Ras	Ras	NNP
cord-001835-0s7ok4uw	4304	16	and	and	CC
cord-001835-0s7ok4uw	4304	17	c	c	NNP
cord-001835-0s7ok4uw	4304	18	-	-	HYPH
cord-001835-0s7ok4uw	4304	19	Myc	Myc	NNP
cord-001835-0s7ok4uw	4304	20	.	.	.
cord-001835-0s7ok4uw	4305	1	Here	here	RB
cord-001835-0s7ok4uw	4305	2	,	,	,
cord-001835-0s7ok4uw	4305	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4305	4	present	present	VBP
cord-001835-0s7ok4uw	4305	5	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4305	6	activity	activity	NN
cord-001835-0s7ok4uw	4305	7	in	in	IN
cord-001835-0s7ok4uw	4305	8	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	4305	9	assays	assay	NNS
cord-001835-0s7ok4uw	4305	10	and	and	CC
cord-001835-0s7ok4uw	4305	11	the	the	DT
cord-001835-0s7ok4uw	4305	12	initial	initial	JJ
cord-001835-0s7ok4uw	4305	13	results	result	NNS
cord-001835-0s7ok4uw	4305	14	on	on	IN
cord-001835-0s7ok4uw	4305	15	generation	generation	NN
cord-001835-0s7ok4uw	4305	16	of	of	IN
cord-001835-0s7ok4uw	4305	17	PE	pe	NN
cord-001835-0s7ok4uw	4305	18	-	-	HYPH
cord-001835-0s7ok4uw	4305	19	based	base	VBN
cord-001835-0s7ok4uw	4305	20	constructs	construct	NNS
cord-001835-0s7ok4uw	4305	21	.	.	.
cord-001835-0s7ok4uw	4306	1	(	(	-LRB-
cord-001835-0s7ok4uw	4306	2	1	1	CD
cord-001835-0s7ok4uw	4306	3	)	)	-RRB-
cord-001835-0s7ok4uw	4306	4	.	.	.
cord-001835-0s7ok4uw	4307	1	Hemagglutinin	Hemagglutinin	NNP
cord-001835-0s7ok4uw	4307	2	is	be	VBZ
cord-001835-0s7ok4uw	4307	3	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	4307	4	as	as	IN
cord-001835-0s7ok4uw	4307	5	HA0	HA0	NNP
cord-001835-0s7ok4uw	4307	6	molecule	molecule	NN
cord-001835-0s7ok4uw	4307	7	assembled	assemble	VBN
cord-001835-0s7ok4uw	4307	8	as	as	IN
cord-001835-0s7ok4uw	4307	9	noncovalently	noncovalently	RB
cord-001835-0s7ok4uw	4307	10	bound	bind	VBN
cord-001835-0s7ok4uw	4307	11	homotrimers	homotrimer	NNS
cord-001835-0s7ok4uw	4307	12	on	on	IN
cord-001835-0s7ok4uw	4307	13	the	the	DT
cord-001835-0s7ok4uw	4307	14	viral	viral	JJ
cord-001835-0s7ok4uw	4307	15	surface	surface	NN
cord-001835-0s7ok4uw	4307	16	.	.	.
cord-001835-0s7ok4uw	4308	1	This	this	DT
cord-001835-0s7ok4uw	4308	2	precursor	precursor	NN
cord-001835-0s7ok4uw	4308	3	protein	protein	NN
cord-001835-0s7ok4uw	4308	4	is	be	VBZ
cord-001835-0s7ok4uw	4308	5	cleaved	cleave	VBN
cord-001835-0s7ok4uw	4308	6	by	by	IN
cord-001835-0s7ok4uw	4308	7	trypsin	trypsin	NN
cord-001835-0s7ok4uw	4308	8	-	-	HYPH
cord-001835-0s7ok4uw	4308	9	like	like	JJ
cord-001835-0s7ok4uw	4308	10	proteases	protease	NNS
cord-001835-0s7ok4uw	4308	11	to	to	TO
cord-001835-0s7ok4uw	4308	12	yield	yield	VB
cord-001835-0s7ok4uw	4308	13	two	two	CD
cord-001835-0s7ok4uw	4308	14	subunits	subunit	NNS
cord-001835-0s7ok4uw	4308	15	HA1	HA1	NNP
cord-001835-0s7ok4uw	4308	16	and	and	CC
cord-001835-0s7ok4uw	4308	17	HA2	HA2	NNP
cord-001835-0s7ok4uw	4308	18	linked	link	VBN
cord-001835-0s7ok4uw	4308	19	by	by	IN
cord-001835-0s7ok4uw	4308	20	a	a	DT
cord-001835-0s7ok4uw	4308	21	single	single	JJ
cord-001835-0s7ok4uw	4308	22	disulphide	disulphide	JJ
cord-001835-0s7ok4uw	4308	23	bond	bond	NN
cord-001835-0s7ok4uw	4308	24	(	(	-LRB-
cord-001835-0s7ok4uw	4308	25	2	2	CD
cord-001835-0s7ok4uw	4308	26	)	)	-RRB-
cord-001835-0s7ok4uw	4308	27	.	.	.
cord-001835-0s7ok4uw	4309	1	HA0	HA0	NNP
cord-001835-0s7ok4uw	4309	2	is	be	VBZ
cord-001835-0s7ok4uw	4309	3	also	also	RB
cord-001835-0s7ok4uw	4309	4	post	post	JJ
cord-001835-0s7ok4uw	4309	5	-	-	JJ
cord-001835-0s7ok4uw	4309	6	translationally	translationally	RB
cord-001835-0s7ok4uw	4309	7	modified	modify	VBN
cord-001835-0s7ok4uw	4309	8	by	by	IN
cord-001835-0s7ok4uw	4309	9	N	n	CD
cord-001835-0s7ok4uw	4309	10	-	-	HYPH
cord-001835-0s7ok4uw	4309	11	glycosylation	glycosylation	NN
cord-001835-0s7ok4uw	4309	12	(	(	-LRB-
cord-001835-0s7ok4uw	4309	13	3	3	CD
cord-001835-0s7ok4uw	4309	14	)	)	-RRB-
cord-001835-0s7ok4uw	4309	15	.	.	.
cord-001835-0s7ok4uw	4310	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4310	2	is	be	VBZ
cord-001835-0s7ok4uw	4310	3	well	well	RB
cord-001835-0s7ok4uw	4310	4	established	establish	VBN
cord-001835-0s7ok4uw	4310	5	that	that	IN
cord-001835-0s7ok4uw	4310	6	the	the	DT
cord-001835-0s7ok4uw	4310	7	virus	virus	NN
cord-001835-0s7ok4uw	4310	8	hemagglutinin	hemagglutinin	NN
cord-001835-0s7ok4uw	4310	9	is	be	VBZ
cord-001835-0s7ok4uw	4310	10	the	the	DT
cord-001835-0s7ok4uw	4310	11	main	main	JJ
cord-001835-0s7ok4uw	4310	12	antigen	antigen	NN
cord-001835-0s7ok4uw	4310	13	,	,	,
cord-001835-0s7ok4uw	4310	14	inducing	induce	VBG
cord-001835-0s7ok4uw	4310	15	the	the	DT
cord-001835-0s7ok4uw	4310	16	neutralizing	neutralize	VBG
cord-001835-0s7ok4uw	4310	17	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4310	18	.	.	.
cord-001835-0s7ok4uw	4311	1	In	in	IN
cord-001835-0s7ok4uw	4311	2	the	the	DT
cord-001835-0s7ok4uw	4311	3	attempt	attempt	NN
cord-001835-0s7ok4uw	4311	4	towards	towards	IN
cord-001835-0s7ok4uw	4311	5	developing	develop	VBG
cord-001835-0s7ok4uw	4311	6	influenza	influenza	JJ
cord-001835-0s7ok4uw	4311	7	vaccine	vaccine	NN
cord-001835-0s7ok4uw	4311	8	production	production	NN
cord-001835-0s7ok4uw	4311	9	(	(	-LRB-
cord-001835-0s7ok4uw	4311	10	the	the	DT
cord-001835-0s7ok4uw	4311	11	egg	egg	NN
cord-001835-0s7ok4uw	4311	12	-	-	HYPH
cord-001835-0s7ok4uw	4311	13	based	base	VBN
cord-001835-0s7ok4uw	4311	14	manufacturing	manufacturing	NN
cord-001835-0s7ok4uw	4311	15	lasts	last	VBZ
cord-001835-0s7ok4uw	4311	16	several	several	JJ
cord-001835-0s7ok4uw	4311	17	months	month	NNS
cord-001835-0s7ok4uw	4311	18	)	)	-RRB-
cord-001835-0s7ok4uw	4311	19	that	that	WDT
cord-001835-0s7ok4uw	4311	20	would	would	MD
cord-001835-0s7ok4uw	4311	21	be	be	VB
cord-001835-0s7ok4uw	4311	22	faster	fast	JJR
cord-001835-0s7ok4uw	4311	23	and	and	CC
cord-001835-0s7ok4uw	4311	24	safer	safe	JJR
cord-001835-0s7ok4uw	4311	25	the	the	DT
cord-001835-0s7ok4uw	4311	26	utilization	utilization	NN
cord-001835-0s7ok4uw	4311	27	of	of	IN
cord-001835-0s7ok4uw	4311	28	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	4311	29	antigen	antigen	NN
cord-001835-0s7ok4uw	4311	30	alone	alone	RB
cord-001835-0s7ok4uw	4311	31	is	be	VBZ
cord-001835-0s7ok4uw	4311	32	currently	currently	RB
cord-001835-0s7ok4uw	4311	33	being	be	VBG
cord-001835-0s7ok4uw	4311	34	observed	observe	VBN
cord-001835-0s7ok4uw	4311	35	.	.	.
cord-001835-0s7ok4uw	4312	1	Recently	recently	RB
cord-001835-0s7ok4uw	4312	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	4312	3	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	4312	4	that	that	IN
cord-001835-0s7ok4uw	4312	5	yeast	yeast	NN
cord-001835-0s7ok4uw	4312	6	produced	produce	VBN
cord-001835-0s7ok4uw	4312	7	influenza	influenza	NN
cord-001835-0s7ok4uw	4312	8	H5	H5	NNP
cord-001835-0s7ok4uw	4312	9	protein	protein	NN
cord-001835-0s7ok4uw	4312	10	although	although	IN
cord-001835-0s7ok4uw	4312	11	cleaved	cleave	VBD
cord-001835-0s7ok4uw	4312	12	into	into	IN
cord-001835-0s7ok4uw	4312	13	two	two	CD
cord-001835-0s7ok4uw	4312	14	subunits	subunit	NNS
cord-001835-0s7ok4uw	4312	15	induced	induce	VBN
cord-001835-0s7ok4uw	4312	16	strong	strong	JJ
cord-001835-0s7ok4uw	4312	17	immunological	immunological	JJ
cord-001835-0s7ok4uw	4312	18	response	response	NN
cord-001835-0s7ok4uw	4312	19	in	in	IN
cord-001835-0s7ok4uw	4312	20	mice	mouse	NNS
cord-001835-0s7ok4uw	4312	21	(	(	-LRB-
cord-001835-0s7ok4uw	4312	22	4	4	CD
cord-001835-0s7ok4uw	4312	23	)	)	-RRB-
cord-001835-0s7ok4uw	4312	24	.	.	.
cord-001835-0s7ok4uw	4313	1	In	in	IN
cord-001835-0s7ok4uw	4313	2	this	this	DT
cord-001835-0s7ok4uw	4313	3	report	report	NN
cord-001835-0s7ok4uw	4313	4	,	,	,
cord-001835-0s7ok4uw	4313	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4313	6	describe	describe	VBP
cord-001835-0s7ok4uw	4313	7	the	the	DT
cord-001835-0s7ok4uw	4313	8	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	4313	9	and	and	CC
cord-001835-0s7ok4uw	4313	10	immunological	immunological	JJ
cord-001835-0s7ok4uw	4313	11	characterization	characterization	NN
cord-001835-0s7ok4uw	4313	12	of	of	IN
cord-001835-0s7ok4uw	4313	13	the	the	DT
cord-001835-0s7ok4uw	4313	14	H5	H5	NNP
cord-001835-0s7ok4uw	4313	15	antigen	antigen	NN
cord-001835-0s7ok4uw	4313	16	,	,	,
cord-001835-0s7ok4uw	4313	17	based	base	VBN
cord-001835-0s7ok4uw	4313	18	on	on	IN
cord-001835-0s7ok4uw	4313	19	hydrolytic	hydrolytic	JJ
cord-001835-0s7ok4uw	4313	20	domain	domain	NN
cord-001835-0s7ok4uw	4313	21	of	of	IN
cord-001835-0s7ok4uw	4313	22	the	the	DT
cord-001835-0s7ok4uw	4313	23	H5N1	H5N1	NNP
cord-001835-0s7ok4uw	4313	24	gene	gene	NN
cord-001835-0s7ok4uw	4313	25	,	,	,
cord-001835-0s7ok4uw	4313	26	with	with	IN
cord-001835-0s7ok4uw	4313	27	deletion	deletion	NN
cord-001835-0s7ok4uw	4313	28	of	of	IN
cord-001835-0s7ok4uw	4313	29	multibasic	multibasic	NNP
cord-001835-0s7ok4uw	4313	30	cleavage	cleavage	NN
cord-001835-0s7ok4uw	4313	31	site	site	NN
cord-001835-0s7ok4uw	4313	32	and	and	CC
cord-001835-0s7ok4uw	4313	33	expressed	express	VBN
cord-001835-0s7ok4uw	4313	34	in	in	IN
cord-001835-0s7ok4uw	4313	35	yeast	yeast	NN
cord-001835-0s7ok4uw	4313	36	system	system	NN
cord-001835-0s7ok4uw	4313	37	.	.	.
cord-001835-0s7ok4uw	4314	1	The	the	DT
cord-001835-0s7ok4uw	4314	2	HA	HA	NNP
cord-001835-0s7ok4uw	4314	3	encoding	encoding	NN
cord-001835-0s7ok4uw	4314	4	gene	gene	NN
cord-001835-0s7ok4uw	4314	5	from	from	IN
cord-001835-0s7ok4uw	4314	6	H5N1	H5N1	NNP
cord-001835-0s7ok4uw	4314	7	virus	virus	NN
cord-001835-0s7ok4uw	4314	8	with	with	IN
cord-001835-0s7ok4uw	4314	9	deletion	deletion	NN
cord-001835-0s7ok4uw	4314	10	of	of	IN
cord-001835-0s7ok4uw	4314	11	18	18	CD
cord-001835-0s7ok4uw	4314	12	nucleotides	nucleotide	NNS
cord-001835-0s7ok4uw	4314	13	was	be	VBD
cord-001835-0s7ok4uw	4314	14	cloned	clone	VBN
cord-001835-0s7ok4uw	4314	15	into	into	IN
cord-001835-0s7ok4uw	4314	16	pPICZaC	ppiczac	NN
cord-001835-0s7ok4uw	4314	17	vector	vector	NN
cord-001835-0s7ok4uw	4314	18	.	.	.
cord-001835-0s7ok4uw	4315	1	rHA	rHA	NNP
cord-001835-0s7ok4uw	4315	2	fusion	fusion	NN
cord-001835-0s7ok4uw	4315	3	protein	protein	NN
cord-001835-0s7ok4uw	4315	4	with	with	IN
cord-001835-0s7ok4uw	4315	5	His6-tag	His6-tag	NNP
cord-001835-0s7ok4uw	4315	6	was	be	VBD
cord-001835-0s7ok4uw	4315	7	secreted	secrete	VBN
cord-001835-0s7ok4uw	4315	8	into	into	IN
cord-001835-0s7ok4uw	4315	9	the	the	DT
cord-001835-0s7ok4uw	4315	10	culture	culture	NN
cord-001835-0s7ok4uw	4315	11	medium	medium	NN
cord-001835-0s7ok4uw	4315	12	and	and	CC
cord-001835-0s7ok4uw	4315	13	was	be	VBD
cord-001835-0s7ok4uw	4315	14	purified	purify	VBN
cord-001835-0s7ok4uw	4315	15	to	to	IN
cord-001835-0s7ok4uw	4315	16	homogeneity	homogeneity	NN
cord-001835-0s7ok4uw	4315	17	in	in	IN
cord-001835-0s7ok4uw	4315	18	one	one	CD
cord-001835-0s7ok4uw	4315	19	step	step	NN
cord-001835-0s7ok4uw	4315	20	using	use	VBG
cord-001835-0s7ok4uw	4315	21	Ni	Ni	NNP
cord-001835-0s7ok4uw	4315	22	-	-	HYPH
cord-001835-0s7ok4uw	4315	23	NTA	NTA	NNP
cord-001835-0s7ok4uw	4315	24	agarose	agarose	VBD
cord-001835-0s7ok4uw	4315	25	.	.	.
cord-001835-0s7ok4uw	4316	1	The	the	DT
cord-001835-0s7ok4uw	4316	2	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4316	3	of	of	IN
cord-001835-0s7ok4uw	4316	4	the	the	DT
cord-001835-0s7ok4uw	4316	5	antigen	antigen	NN
cord-001835-0s7ok4uw	4316	6	purification	purification	NN
cord-001835-0s7ok4uw	4316	7	was	be	VBD
cord-001835-0s7ok4uw	4316	8	200	200	CD
cord-001835-0s7ok4uw	4316	9	mg	mg	NNP
cord-001835-0s7ok4uw	4316	10	/	/	SYM
cord-001835-0s7ok4uw	4316	11	L.	L.	NNP
cord-001835-0s7ok4uw	4316	12	Glycosylation	Glycosylation	NNP
cord-001835-0s7ok4uw	4316	13	sites	site	NNS
cord-001835-0s7ok4uw	4316	14	of	of	IN
cord-001835-0s7ok4uw	4316	15	rHA	rHA	NNS
cord-001835-0s7ok4uw	4316	16	were	be	VBD
cord-001835-0s7ok4uw	4316	17	determined	determine	VBN
cord-001835-0s7ok4uw	4316	18	using	use	VBG
cord-001835-0s7ok4uw	4316	19	LC	LC	NNP
cord-001835-0s7ok4uw	4316	20	-	-	HYPH
cord-001835-0s7ok4uw	4316	21	MS	MS	NNP
cord-001835-0s7ok4uw	4316	22	-	-	HYPH
cord-001835-0s7ok4uw	4316	23	MS	MS	NNP
cord-001835-0s7ok4uw	4316	24	/	/	SYM
cord-001835-0s7ok4uw	4316	25	MS	MS	NNP
cord-001835-0s7ok4uw	4316	26	.	.	.
cord-001835-0s7ok4uw	4317	1	Analysis	analysis	NN
cord-001835-0s7ok4uw	4317	2	of	of	IN
cord-001835-0s7ok4uw	4317	3	the	the	DT
cord-001835-0s7ok4uw	4317	4	N	n	NN
cord-001835-0s7ok4uw	4317	5	-	-	HYPH
cord-001835-0s7ok4uw	4317	6	linked	link	VBN
cord-001835-0s7ok4uw	4317	7	glycans	glycan	NNS
cord-001835-0s7ok4uw	4317	8	revealed	reveal	VBD
cord-001835-0s7ok4uw	4317	9	that	that	IN
cord-001835-0s7ok4uw	4317	10	the	the	DT
cord-001835-0s7ok4uw	4317	11	rHA	rHA	NNP
cord-001835-0s7ok4uw	4317	12	is	be	VBZ
cord-001835-0s7ok4uw	4317	13	glycosylated	glycosylate	VBN
cord-001835-0s7ok4uw	4317	14	at	at	IN
cord-001835-0s7ok4uw	4317	15	the	the	DT
cord-001835-0s7ok4uw	4317	16	same	same	JJ
cord-001835-0s7ok4uw	4317	17	sites	site	NNS
cord-001835-0s7ok4uw	4317	18	as	as	IN
cord-001835-0s7ok4uw	4317	19	the	the	DT
cord-001835-0s7ok4uw	4317	20	native	native	JJ
cord-001835-0s7ok4uw	4317	21	HA	HA	NNP
cord-001835-0s7ok4uw	4317	22	in	in	IN
cord-001835-0s7ok4uw	4317	23	the	the	DT
cord-001835-0s7ok4uw	4317	24	vaccine	vaccine	NN
cord-001835-0s7ok4uw	4317	25	strain	strain	NN
cord-001835-0s7ok4uw	4317	26	.	.	.
cord-001835-0s7ok4uw	4318	1	Next	next	RB
cord-001835-0s7ok4uw	4318	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	4318	3	investigated	investigate	VBD
cord-001835-0s7ok4uw	4318	4	if	if	IN
cord-001835-0s7ok4uw	4318	5	the	the	DT
cord-001835-0s7ok4uw	4318	6	hemagglutinin	hemagglutinin	NN
cord-001835-0s7ok4uw	4318	7	with	with	IN
cord-001835-0s7ok4uw	4318	8	deletion	deletion	NN
cord-001835-0s7ok4uw	4318	9	of	of	IN
cord-001835-0s7ok4uw	4318	10	the	the	DT
cord-001835-0s7ok4uw	4318	11	cleavage	cleavage	NN
cord-001835-0s7ok4uw	4318	12	site	site	NN
cord-001835-0s7ok4uw	4318	13	oligomerize	oligomerize	NN
cord-001835-0s7ok4uw	4318	14	into	into	IN
cord-001835-0s7ok4uw	4318	15	higher	high	JJR
cord-001835-0s7ok4uw	4318	16	molecular	molecular	JJ
cord-001835-0s7ok4uw	4318	17	forms	form	NNS
cord-001835-0s7ok4uw	4318	18	.	.	.
cord-001835-0s7ok4uw	4319	1	To	to	TO
cord-001835-0s7ok4uw	4319	2	determine	determine	VB
cord-001835-0s7ok4uw	4319	3	the	the	DT
cord-001835-0s7ok4uw	4319	4	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	4319	5	forms	form	NNS
cord-001835-0s7ok4uw	4319	6	of	of	IN
cord-001835-0s7ok4uw	4319	7	the	the	DT
cord-001835-0s7ok4uw	4319	8	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	4319	9	antigen	antigen	NN
cord-001835-0s7ok4uw	4319	10	various	various	JJ
cord-001835-0s7ok4uw	4319	11	approaches	approach	NNS
cord-001835-0s7ok4uw	4319	12	were	be	VBD
cord-001835-0s7ok4uw	4319	13	applied	apply	VBN
cord-001835-0s7ok4uw	4319	14	e.g.	e.g.	IN
cord-001835-0s7ok4uw	4319	15	Native	Native	NNP
cord-001835-0s7ok4uw	4319	16	-	-	HYPH
cord-001835-0s7ok4uw	4319	17	Page	Page	NNP
cord-001835-0s7ok4uw	4319	18	,	,	,
cord-001835-0s7ok4uw	4319	19	Size	Size	NNP
cord-001835-0s7ok4uw	4319	20	Exclusion	Exclusion	NNP
cord-001835-0s7ok4uw	4319	21	Chromatography	Chromatography	NNP
cord-001835-0s7ok4uw	4319	22	or	or	CC
cord-001835-0s7ok4uw	4319	23	Dynamic	Dynamic	NNP
cord-001835-0s7ok4uw	4319	24	Light	Light	NNP
cord-001835-0s7ok4uw	4319	25	Scattering	Scattering	NNP
cord-001835-0s7ok4uw	4319	26	.	.	.
cord-001835-0s7ok4uw	4320	1	As	as	IN
cord-001835-0s7ok4uw	4320	2	a	a	DT
cord-001835-0s7ok4uw	4320	3	final	final	JJ
cord-001835-0s7ok4uw	4320	4	experiment	experiment	NN
cord-001835-0s7ok4uw	4320	5	to	to	TO
cord-001835-0s7ok4uw	4320	6	measure	measure	VB
cord-001835-0s7ok4uw	4320	7	the	the	DT
cord-001835-0s7ok4uw	4320	8	size	size	NN
cord-001835-0s7ok4uw	4320	9	of	of	IN
cord-001835-0s7ok4uw	4320	10	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	4320	11	in	in	IN
cord-001835-0s7ok4uw	4320	12	a	a	DT
cord-001835-0s7ok4uw	4320	13	protein	protein	NN
cord-001835-0s7ok4uw	4320	14	sample	sample	NN
cord-001835-0s7ok4uw	4321	1	a	a	DT
cord-001835-0s7ok4uw	4321	2	combined	combined	JJ
cord-001835-0s7ok4uw	4321	3	technology	technology	NN
cord-001835-0s7ok4uw	4321	4	SEC	SEC	NNP
cord-001835-0s7ok4uw	4321	5	-	-	HYPH
cord-001835-0s7ok4uw	4321	6	MALS	MALS	NNP
cord-001835-0s7ok4uw	4321	7	was	be	VBD
cord-001835-0s7ok4uw	4321	8	conducted	conduct	VBN
cord-001835-0s7ok4uw	4321	9	,	,	,
cord-001835-0s7ok4uw	4321	10	using	use	VBG
cord-001835-0s7ok4uw	4321	11	multi	multi	JJ
cord-001835-0s7ok4uw	4321	12	angle	angle	NN
cord-001835-0s7ok4uw	4321	13	light	light	JJ
cord-001835-0s7ok4uw	4321	14	scattering	scattering	NN
cord-001835-0s7ok4uw	4321	15	(	(	-LRB-
cord-001835-0s7ok4uw	4321	16	MALS	MALS	NNP
cord-001835-0s7ok4uw	4321	17	)	)	-RRB-
cord-001835-0s7ok4uw	4321	18	as	as	IN
cord-001835-0s7ok4uw	4321	19	a	a	DT
cord-001835-0s7ok4uw	4321	20	detector	detector	NN
cord-001835-0s7ok4uw	4321	21	.	.	.
cord-001835-0s7ok4uw	4322	1	The	the	DT
cord-001835-0s7ok4uw	4322	2	immunological	immunological	JJ
cord-001835-0s7ok4uw	4322	3	activity	activity	NN
cord-001835-0s7ok4uw	4322	4	of	of	IN
cord-001835-0s7ok4uw	4322	5	rHA	rHA	NNP
cord-001835-0s7ok4uw	4322	6	was	be	VBD
cord-001835-0s7ok4uw	4322	7	tested	test	VBN
cord-001835-0s7ok4uw	4322	8	in	in	IN
cord-001835-0s7ok4uw	4322	9	chicken	chicken	NN
cord-001835-0s7ok4uw	4322	10	and	and	CC
cord-001835-0s7ok4uw	4322	11	mice	mouse	NNS
cord-001835-0s7ok4uw	4322	12	,	,	,
cord-001835-0s7ok4uw	4322	13	where	where	WRB
cord-001835-0s7ok4uw	4322	14	antigen	antigen	NN
cord-001835-0s7ok4uw	4322	15	elicited	elicit	VBD
cord-001835-0s7ok4uw	4322	16	high	high	JJ
cord-001835-0s7ok4uw	4322	17	immune	immune	JJ
cord-001835-0s7ok4uw	4322	18	response	response	NN
cord-001835-0s7ok4uw	4322	19	.	.	.
cord-001835-0s7ok4uw	4323	1	The	the	DT
cord-001835-0s7ok4uw	4323	2	data	datum	NNS
cord-001835-0s7ok4uw	4323	3	presented	present	VBN
cord-001835-0s7ok4uw	4323	4	here	here	RB
cord-001835-0s7ok4uw	4323	5	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	4323	6	that	that	IN
cord-001835-0s7ok4uw	4323	7	new	new	JJ
cord-001835-0s7ok4uw	4323	8	influenza	influenza	NN
cord-001835-0s7ok4uw	4323	9	antigen	antigen	NN
cord-001835-0s7ok4uw	4323	10	produced	produce	VBN
cord-001835-0s7ok4uw	4323	11	in	in	IN
cord-001835-0s7ok4uw	4323	12	P.	P.	NNP
cord-001835-0s7ok4uw	4323	13	pastoris	pastoris	NN
cord-001835-0s7ok4uw	4323	14	is	be	VBZ
cord-001835-0s7ok4uw	4323	15	highly	highly	RB
cord-001835-0s7ok4uw	4323	16	immunogenic	immunogenic	JJ
cord-001835-0s7ok4uw	4323	17	and	and	CC
cord-001835-0s7ok4uw	4323	18	might	may	MD
cord-001835-0s7ok4uw	4323	19	be	be	VB
cord-001835-0s7ok4uw	4323	20	consider	consider	VB
cord-001835-0s7ok4uw	4323	21	as	as	IN
cord-001835-0s7ok4uw	4323	22	a	a	DT
cord-001835-0s7ok4uw	4323	23	candidate	candidate	NN
cord-001835-0s7ok4uw	4323	24	for	for	IN
cord-001835-0s7ok4uw	4323	25	subunit	subunit	NN
cord-001835-0s7ok4uw	4323	26	vaccine	vaccine	NN
cord-001835-0s7ok4uw	4323	27	.	.	.
cord-001835-0s7ok4uw	4323	28	 	 	_SP
cord-001835-0s7ok4uw	4324	1	Structural	structural	JJ
cord-001835-0s7ok4uw	4324	2	motifs	motif	NNS
cord-001835-0s7ok4uw	4324	3	capture	capture	VBP
cord-001835-0s7ok4uw	4324	4	redundant	redundant	JJ
cord-001835-0s7ok4uw	4324	5	patterns	pattern	NNS
cord-001835-0s7ok4uw	4324	6	that	that	WDT
cord-001835-0s7ok4uw	4324	7	frequently	frequently	RB
cord-001835-0s7ok4uw	4324	8	occur	occur	VBP
cord-001835-0s7ok4uw	4324	9	in	in	IN
cord-001835-0s7ok4uw	4324	10	proteins	protein	NNS
cord-001835-0s7ok4uw	4324	11	.	.	.
cord-001835-0s7ok4uw	4325	1	Motifs	motif	NNS
cord-001835-0s7ok4uw	4325	2	associated	associate	VBN
cord-001835-0s7ok4uw	4325	3	with	with	IN
cord-001835-0s7ok4uw	4325	4	contiguous	contiguous	JJ
cord-001835-0s7ok4uw	4325	5	fragments	fragment	NNS
cord-001835-0s7ok4uw	4325	6	of	of	IN
cord-001835-0s7ok4uw	4325	7	structure	structure	NN
cord-001835-0s7ok4uw	4325	8	(	(	-LRB-
cord-001835-0s7ok4uw	4325	9	i.e.	i.e.	FW
cord-001835-0s7ok4uw	4325	10	,	,	,
cord-001835-0s7ok4uw	4325	11	secondary	secondary	JJ
cord-001835-0s7ok4uw	4325	12	structural	structural	JJ
cord-001835-0s7ok4uw	4325	13	motifs	motif	NNS
cord-001835-0s7ok4uw	4325	14	)	)	-RRB-
cord-001835-0s7ok4uw	4325	15	are	be	VBP
cord-001835-0s7ok4uw	4325	16	well	well	RB
cord-001835-0s7ok4uw	4325	17	studied	study	VBN
cord-001835-0s7ok4uw	4325	18	and	and	CC
cord-001835-0s7ok4uw	4325	19	have	have	VBP
cord-001835-0s7ok4uw	4325	20	been	be	VBN
cord-001835-0s7ok4uw	4325	21	successfully	successfully	RB
cord-001835-0s7ok4uw	4325	22	used	use	VBN
cord-001835-0s7ok4uw	4325	23	to	to	TO
cord-001835-0s7ok4uw	4325	24	capture	capture	VB
cord-001835-0s7ok4uw	4325	25	"	"	``
cord-001835-0s7ok4uw	4325	26	rules	rule	NNS
cord-001835-0s7ok4uw	4325	27	"	"	''
cord-001835-0s7ok4uw	4325	28	describing	describe	VBG
cord-001835-0s7ok4uw	4325	29	sequence	sequence	NN
cord-001835-0s7ok4uw	4325	30	-	-	HYPH
cord-001835-0s7ok4uw	4325	31	structure	structure	NN
cord-001835-0s7ok4uw	4325	32	relationships	relationship	NNS
cord-001835-0s7ok4uw	4325	33	in	in	IN
cord-001835-0s7ok4uw	4325	34	protein	protein	NN
cord-001835-0s7ok4uw	4325	35	design	design	NN
cord-001835-0s7ok4uw	4325	36	and	and	CC
cord-001835-0s7ok4uw	4325	37	structure	structure	NN
cord-001835-0s7ok4uw	4325	38	prediction	prediction	NN
cord-001835-0s7ok4uw	4325	39	.	.	.
cord-001835-0s7ok4uw	4326	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4326	2	have	have	VBP
cord-001835-0s7ok4uw	4326	3	extended	extend	VBN
cord-001835-0s7ok4uw	4326	4	this	this	DT
cord-001835-0s7ok4uw	4326	5	concept	concept	NN
cord-001835-0s7ok4uw	4326	6	to	to	IN
cord-001835-0s7ok4uw	4326	7	motifs	motif	NNS
cord-001835-0s7ok4uw	4326	8	that	that	WDT
cord-001835-0s7ok4uw	4326	9	capture	capture	VBP
cord-001835-0s7ok4uw	4326	10	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	4326	11	information-(i.e	information-(i.e	ADD
cord-001835-0s7ok4uw	4326	12	.	.	.
cord-001835-0s7ok4uw	4327	1	,	,	,
cord-001835-0s7ok4uw	4327	2	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	4327	3	structural	structural	JJ
cord-001835-0s7ok4uw	4327	4	motifs	motif	NNS
cord-001835-0s7ok4uw	4327	5	or	or	CC
cord-001835-0s7ok4uw	4327	6	TERMs	term	NNS
cord-001835-0s7ok4uw	4327	7	.	.	.
cord-001835-0s7ok4uw	4328	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4328	2	have	have	VBP
cord-001835-0s7ok4uw	4328	3	discovered	discover	VBN
cord-001835-0s7ok4uw	4328	4	that	that	IN
cord-001835-0s7ok4uw	4328	5	a	a	DT
cord-001835-0s7ok4uw	4328	6	relatively	relatively	RB
cord-001835-0s7ok4uw	4328	7	small	small	JJ
cord-001835-0s7ok4uw	4328	8	alphabet	alphabet	NN
cord-001835-0s7ok4uw	4328	9	of	of	IN
cord-001835-0s7ok4uw	4328	10	TERMs	term	NNS
cord-001835-0s7ok4uw	4328	11	describes	describe	VBZ
cord-001835-0s7ok4uw	4328	12	the	the	DT
cord-001835-0s7ok4uw	4328	13	known	know	VBN
cord-001835-0s7ok4uw	4328	14	structural	structural	JJ
cord-001835-0s7ok4uw	4328	15	universe	universe	NN
cord-001835-0s7ok4uw	4328	16	(	(	-LRB-
cord-001835-0s7ok4uw	4328	17	all	all	DT
cord-001835-0s7ok4uw	4328	18	secondary	secondary	JJ
cord-001835-0s7ok4uw	4328	19	,	,	,
cord-001835-0s7ok4uw	4328	20	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	4328	21	and	and	CC
cord-001835-0s7ok4uw	4328	22	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	4328	23	information	information	NN
cord-001835-0s7ok4uw	4328	24	in	in	IN
cord-001835-0s7ok4uw	4328	25	the	the	DT
cord-001835-0s7ok4uw	4328	26	PDB	PDB	NNP
cord-001835-0s7ok4uw	4328	27	)	)	-RRB-
cord-001835-0s7ok4uw	4328	28	at	at	IN
cord-001835-0s7ok4uw	4328	29	sub	sub	JJ
cord-001835-0s7ok4uw	4328	30	-	-	JJ
cord-001835-0s7ok4uw	4328	31	Angstrom	angstrom	JJ
cord-001835-0s7ok4uw	4328	32	resolution	resolution	NN
cord-001835-0s7ok4uw	4328	33	.	.	.
cord-001835-0s7ok4uw	4329	1	This	this	DT
cord-001835-0s7ok4uw	4329	2	alphabet	alphabet	NN
cord-001835-0s7ok4uw	4329	3	of	of	IN
cord-001835-0s7ok4uw	4329	4	universal	universal	JJ
cord-001835-0s7ok4uw	4329	5	motifs	motif	NNS
cord-001835-0s7ok4uw	4329	6	reveals	reveal	VBZ
cord-001835-0s7ok4uw	4329	7	the	the	DT
cord-001835-0s7ok4uw	4329	8	remarkable	remarkable	JJ
cord-001835-0s7ok4uw	4329	9	degeneracy	degeneracy	NN
cord-001835-0s7ok4uw	4329	10	of	of	IN
cord-001835-0s7ok4uw	4329	11	the	the	DT
cord-001835-0s7ok4uw	4329	12	protein	protein	NN
cord-001835-0s7ok4uw	4329	13	structure	structure	NN
cord-001835-0s7ok4uw	4329	14	space	space	NN
cord-001835-0s7ok4uw	4329	15	,	,	,
cord-001835-0s7ok4uw	4329	16	with	with	IN
cord-001835-0s7ok4uw	4329	17	just	just	RB
cord-001835-0s7ok4uw	4329	18	a	a	DT
cord-001835-0s7ok4uw	4329	19	few	few	JJ
cord-001835-0s7ok4uw	4329	20	hundred	hundred	CD
cord-001835-0s7ok4uw	4329	21	TERMs	term	NNS
cord-001835-0s7ok4uw	4329	22	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	4329	23	to	to	TO
cord-001835-0s7ok4uw	4329	24	accurately	accurately	RB
cord-001835-0s7ok4uw	4329	25	capture	capture	VB
cord-001835-0s7ok4uw	4329	26	half	half	NN
cord-001835-0s7ok4uw	4329	27	of	of	IN
cord-001835-0s7ok4uw	4329	28	the	the	DT
cord-001835-0s7ok4uw	4329	29	known	know	VBN
cord-001835-0s7ok4uw	4329	30	structural	structural	JJ
cord-001835-0s7ok4uw	4329	31	universe	universe	NN
cord-001835-0s7ok4uw	4329	32	.	.	.
cord-001835-0s7ok4uw	4330	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4330	2	have	have	VBP
cord-001835-0s7ok4uw	4330	3	begun	begin	VBN
cord-001835-0s7ok4uw	4330	4	to	to	TO
cord-001835-0s7ok4uw	4330	5	demonstrate	demonstrate	VB
cord-001835-0s7ok4uw	4330	6	the	the	DT
cord-001835-0s7ok4uw	4330	7	considerable	considerable	JJ
cord-001835-0s7ok4uw	4330	8	promise	promise	NN
cord-001835-0s7ok4uw	4330	9	this	this	DT
cord-001835-0s7ok4uw	4330	10	structural	structural	JJ
cord-001835-0s7ok4uw	4330	11	alphabet	alphabet	NN
cord-001835-0s7ok4uw	4330	12	has	have	VBZ
cord-001835-0s7ok4uw	4330	13	for	for	IN
cord-001835-0s7ok4uw	4330	14	applications	application	NNS
cord-001835-0s7ok4uw	4330	15	such	such	JJ
cord-001835-0s7ok4uw	4330	16	as	as	IN
cord-001835-0s7ok4uw	4330	17	protein	protein	NN
cord-001835-0s7ok4uw	4330	18	design	design	NN
cord-001835-0s7ok4uw	4330	19	,	,	,
cord-001835-0s7ok4uw	4330	20	structure	structure	NN
cord-001835-0s7ok4uw	4330	21	prediction	prediction	NN
cord-001835-0s7ok4uw	4330	22	,	,	,
cord-001835-0s7ok4uw	4330	23	and	and	CC
cord-001835-0s7ok4uw	4330	24	docking	docking	NN
cord-001835-0s7ok4uw	4330	25	.	.	.
cord-001835-0s7ok4uw	4331	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4331	2	have	have	VBP
cord-001835-0s7ok4uw	4331	3	developed	develop	VBN
cord-001835-0s7ok4uw	4331	4	a	a	DT
cord-001835-0s7ok4uw	4331	5	novel	novel	JJ
cord-001835-0s7ok4uw	4331	6	protein	protein	NN
cord-001835-0s7ok4uw	4331	7	design	design	NN
cord-001835-0s7ok4uw	4331	8	framework	framework	NN
cord-001835-0s7ok4uw	4331	9	that	that	WDT
cord-001835-0s7ok4uw	4331	10	selects	select	VBZ
cord-001835-0s7ok4uw	4331	11	amino	amino	JJ
cord-001835-0s7ok4uw	4331	12	acid	acid	NN
cord-001835-0s7ok4uw	4331	13	sequences	sequence	NNS
cord-001835-0s7ok4uw	4331	14	,	,	,
cord-001835-0s7ok4uw	4331	15	given	give	VBN
cord-001835-0s7ok4uw	4331	16	a	a	DT
cord-001835-0s7ok4uw	4331	17	desired	desire	VBN
cord-001835-0s7ok4uw	4331	18	structure	structure	NN
cord-001835-0s7ok4uw	4331	19	,	,	,
cord-001835-0s7ok4uw	4331	20	using	use	VBG
cord-001835-0s7ok4uw	4331	21	solely	solely	RB
cord-001835-0s7ok4uw	4331	22	information	information	NN
cord-001835-0s7ok4uw	4331	23	from	from	IN
cord-001835-0s7ok4uw	4331	24	the	the	DT
cord-001835-0s7ok4uw	4331	25	universal	universal	JJ
cord-001835-0s7ok4uw	4331	26	TERMs	term	NNS
cord-001835-0s7ok4uw	4331	27	.	.	.
cord-001835-0s7ok4uw	4332	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4332	2	show	show	VBP
cord-001835-0s7ok4uw	4332	3	that	that	IN
cord-001835-0s7ok4uw	4332	4	given	give	VBN
cord-001835-0s7ok4uw	4332	5	a	a	DT
cord-001835-0s7ok4uw	4332	6	native	native	JJ
cord-001835-0s7ok4uw	4332	7	backbone	backbone	NN
cord-001835-0s7ok4uw	4332	8	,	,	,
cord-001835-0s7ok4uw	4332	9	this	this	DT
cord-001835-0s7ok4uw	4332	10	framework	framework	NN
cord-001835-0s7ok4uw	4332	11	recovers	recover	VBZ
cord-001835-0s7ok4uw	4332	12	the	the	DT
cord-001835-0s7ok4uw	4332	13	native	native	JJ
cord-001835-0s7ok4uw	4332	14	sequences	sequence	NNS
cord-001835-0s7ok4uw	4332	15	to	to	IN
cord-001835-0s7ok4uw	4332	16	a	a	DT
cord-001835-0s7ok4uw	4332	17	level	level	NN
cord-001835-0s7ok4uw	4332	18	on	on	IN
cord-001835-0s7ok4uw	4332	19	par	par	NN
cord-001835-0s7ok4uw	4332	20	with	with	IN
cord-001835-0s7ok4uw	4332	21	state	state	NN
cord-001835-0s7ok4uw	4332	22	-	-	HYPH
cord-001835-0s7ok4uw	4332	23	of	of	IN
cord-001835-0s7ok4uw	4332	24	-	-	HYPH
cord-001835-0s7ok4uw	4332	25	the	the	DT
cord-001835-0s7ok4uw	4332	26	-	-	HYPH
cord-001835-0s7ok4uw	4332	27	art	art	NN
cord-001835-0s7ok4uw	4332	28	atomistic	atomistic	JJ
cord-001835-0s7ok4uw	4332	29	protein	protein	NN
cord-001835-0s7ok4uw	4332	30	design	design	NN
cord-001835-0s7ok4uw	4332	31	methods	method	NNS
cord-001835-0s7ok4uw	4332	32	,	,	,
cord-001835-0s7ok4uw	4332	33	indicating	indicate	VBG
cord-001835-0s7ok4uw	4332	34	that	that	IN
cord-001835-0s7ok4uw	4332	35	the	the	DT
cord-001835-0s7ok4uw	4332	36	motifs	motif	NNS
cord-001835-0s7ok4uw	4332	37	capture	capture	VBP
cord-001835-0s7ok4uw	4332	38	the	the	DT
cord-001835-0s7ok4uw	4332	39	salient	salient	JJ
cord-001835-0s7ok4uw	4332	40	structural	structural	JJ
cord-001835-0s7ok4uw	4332	41	rules	rule	NNS
cord-001835-0s7ok4uw	4332	42	governing	govern	VBG
cord-001835-0s7ok4uw	4332	43	native	native	JJ
cord-001835-0s7ok4uw	4332	44	proteins	protein	NNS
cord-001835-0s7ok4uw	4332	45	.	.	.
cord-001835-0s7ok4uw	4333	1	Further	further	RB
cord-001835-0s7ok4uw	4333	2	,	,	,
cord-001835-0s7ok4uw	4333	3	predicted	predict	VBD
cord-001835-0s7ok4uw	4333	4	sequence	sequence	NN
cord-001835-0s7ok4uw	4333	5	distributions	distribution	NNS
cord-001835-0s7ok4uw	4333	6	agree	agree	VBP
cord-001835-0s7ok4uw	4333	7	closely	closely	RB
cord-001835-0s7ok4uw	4333	8	with	with	IN
cord-001835-0s7ok4uw	4333	9	observed	observed	JJ
cord-001835-0s7ok4uw	4333	10	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	4333	11	variation	variation	NN
cord-001835-0s7ok4uw	4333	12	.	.	.
cord-001835-0s7ok4uw	4334	1	Given	give	VBN
cord-001835-0s7ok4uw	4334	2	the	the	DT
cord-001835-0s7ok4uw	4334	3	apparently	apparently	RB
cord-001835-0s7ok4uw	4334	4	high	high	JJ
cord-001835-0s7ok4uw	4334	5	degeneracy	degeneracy	NN
cord-001835-0s7ok4uw	4334	6	among	among	IN
cord-001835-0s7ok4uw	4334	7	even	even	RB
cord-001835-0s7ok4uw	4334	8	complex	complex	JJ
cord-001835-0s7ok4uw	4334	9	features	feature	NNS
cord-001835-0s7ok4uw	4334	10	of	of	IN
cord-001835-0s7ok4uw	4334	11	protein	protein	NN
cord-001835-0s7ok4uw	4334	12	structure	structure	NN
cord-001835-0s7ok4uw	4334	13	,	,	,
cord-001835-0s7ok4uw	4334	14	methods	method	NNS
cord-001835-0s7ok4uw	4334	15	based	base	VBN
cord-001835-0s7ok4uw	4334	16	on	on	IN
cord-001835-0s7ok4uw	4334	17	mining	mine	VBG
cord-001835-0s7ok4uw	4334	18	the	the	DT
cord-001835-0s7ok4uw	4334	19	PDB	PDB	NNP
cord-001835-0s7ok4uw	4334	20	for	for	IN
cord-001835-0s7ok4uw	4334	21	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	4334	22	information	information	NN
cord-001835-0s7ok4uw	4334	23	should	should	MD
cord-001835-0s7ok4uw	4334	24	provide	provide	VB
cord-001835-0s7ok4uw	4334	25	ample	ample	JJ
cord-001835-0s7ok4uw	4334	26	opportunities	opportunity	NNS
cord-001835-0s7ok4uw	4334	27	for	for	IN
cord-001835-0s7ok4uw	4334	28	advancement	advancement	NN
cord-001835-0s7ok4uw	4334	29	in	in	IN
cord-001835-0s7ok4uw	4334	30	problems	problem	NNS
cord-001835-0s7ok4uw	4334	31	of	of	IN
cord-001835-0s7ok4uw	4334	32	computational	computational	JJ
cord-001835-0s7ok4uw	4334	33	structural	structural	JJ
cord-001835-0s7ok4uw	4334	34	biology	biology	NN
cord-001835-0s7ok4uw	4334	35	.	.	.
cord-001835-0s7ok4uw	4335	1	Sortase	Sortase	NNP
cord-001835-0s7ok4uw	4335	2	-	-	HYPH
cord-001835-0s7ok4uw	4335	3	mediated	mediate	VBN
cord-001835-0s7ok4uw	4335	4	synthesis	synthesis	NN
cord-001835-0s7ok4uw	4335	5	of	of	IN
cord-001835-0s7ok4uw	4335	6	protein	protein	NN
cord-001835-0s7ok4uw	4335	7	-	-	HYPH
cord-001835-0s7ok4uw	4335	8	DNA	dna	NN
cord-001835-0s7ok4uw	4335	9	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	4335	10	for	for	IN
cord-001835-0s7ok4uw	4335	11	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	4335	12	biosensing	biosensing	NN
cord-001835-0s7ok4uw	4335	13	Bedabrata	Bedabrata	NNP
cord-001835-0s7ok4uw	4335	14	Saha	Saha	NNP
cord-001835-0s7ok4uw	4335	15	1	1	CD
cord-001835-0s7ok4uw	4335	16	,	,	,
cord-001835-0s7ok4uw	4335	17	Marieke	Marieke	NNP
cord-001835-0s7ok4uw	4335	18	op	op	NN
cord-001835-0s7ok4uw	4335	19	de	de	NNP
cord-001835-0s7ok4uw	4335	20	Beeck	Beeck	NNP
cord-001835-0s7ok4uw	4335	21	1	1	CD
cord-001835-0s7ok4uw	4335	22	,	,	,
cord-001835-0s7ok4uw	4335	23	Remco	Remco	NNP
cord-001835-0s7ok4uw	4335	24	Arts	Arts	NNP
cord-001835-0s7ok4uw	4335	25	1	1	CD
cord-001835-0s7ok4uw	4336	1	,	,	,
cord-001835-0s7ok4uw	4336	2	Maarten	Maarten	NNP
cord-001835-0s7ok4uw	4336	3	Merkx	Merkx	NNP
cord-001835-0s7ok4uw	4336	4	1	1	CD
cord-001835-0s7ok4uw	4336	5	1	1	CD
cord-001835-0s7ok4uw	4337	1	In	in	IN
cord-001835-0s7ok4uw	4337	2	recent	recent	JJ
cord-001835-0s7ok4uw	4337	3	years	year	NNS
cord-001835-0s7ok4uw	4337	4	,	,	,
cord-001835-0s7ok4uw	4337	5	semisynthetic	semisynthetic	JJ
cord-001835-0s7ok4uw	4337	6	protein	protein	NN
cord-001835-0s7ok4uw	4337	7	-	-	HYPH
cord-001835-0s7ok4uw	4337	8	DNA	dna	NN
cord-001835-0s7ok4uw	4337	9	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	4337	10	have	have	VBP
cord-001835-0s7ok4uw	4337	11	emerged	emerge	VBN
cord-001835-0s7ok4uw	4337	12	as	as	IN
cord-001835-0s7ok4uw	4337	13	attractive	attractive	JJ
cord-001835-0s7ok4uw	4337	14	biomacromolecules	biomacromolecule	NNS
cord-001835-0s7ok4uw	4337	15	for	for	IN
cord-001835-0s7ok4uw	4337	16	different	different	JJ
cord-001835-0s7ok4uw	4337	17	applications	application	NNS
cord-001835-0s7ok4uw	4337	18	in	in	IN
cord-001835-0s7ok4uw	4337	19	bio	bio	NN
cord-001835-0s7ok4uw	4337	20	-	-	HYPH
cord-001835-0s7ok4uw	4337	21	nanotechnology	nanotechnology	NNP
cord-001835-0s7ok4uw	4337	22	,	,	,
cord-001835-0s7ok4uw	4337	23	biosensing	biosensing	NN
cord-001835-0s7ok4uw	4337	24	,	,	,
cord-001835-0s7ok4uw	4337	25	diagnostics	diagnostic	NNS
cord-001835-0s7ok4uw	4337	26	and	and	CC
cord-001835-0s7ok4uw	4337	27	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	4337	28	.	.	.
cord-001835-0s7ok4uw	4338	1	In	in	IN
cord-001835-0s7ok4uw	4338	2	protein	protein	NN
cord-001835-0s7ok4uw	4338	3	-	-	HYPH
cord-001835-0s7ok4uw	4338	4	DNA	dna	NN
cord-001835-0s7ok4uw	4338	5	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	4338	6	,	,	,
cord-001835-0s7ok4uw	4338	7	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	4338	8	oligonucleotides	oligonucleotide	NNS
cord-001835-0s7ok4uw	4338	9	allow	allow	VBP
cord-001835-0s7ok4uw	4338	10	the	the	DT
cord-001835-0s7ok4uw	4338	11	construction	construction	NN
cord-001835-0s7ok4uw	4338	12	of	of	IN
cord-001835-0s7ok4uw	4338	13	desired	desire	VBN
cord-001835-0s7ok4uw	4338	14	molecular	molecular	JJ
cord-001835-0s7ok4uw	4338	15	architecture	architecture	NN
cord-001835-0s7ok4uw	4338	16	with	with	IN
cord-001835-0s7ok4uw	4338	17	high	high	JJ
cord-001835-0s7ok4uw	4338	18	specificity	specificity	NN
cord-001835-0s7ok4uw	4338	19	,	,	,
cord-001835-0s7ok4uw	4338	20	while	while	IN
cord-001835-0s7ok4uw	4338	21	maintaining	maintain	VBG
cord-001835-0s7ok4uw	4338	22	the	the	DT
cord-001835-0s7ok4uw	4338	23	original	original	JJ
cord-001835-0s7ok4uw	4338	24	functionality	functionality	NN
cord-001835-0s7ok4uw	4338	25	of	of	IN
cord-001835-0s7ok4uw	4338	26	the	the	DT
cord-001835-0s7ok4uw	4338	27	protein	protein	NN
cord-001835-0s7ok4uw	4338	28	molecules	molecule	NNS
cord-001835-0s7ok4uw	4338	29	for	for	IN
cord-001835-0s7ok4uw	4338	30	desired	desire	VBN
cord-001835-0s7ok4uw	4338	31	application	application	NN
cord-001835-0s7ok4uw	4338	32	.	.	.
cord-001835-0s7ok4uw	4339	1	However	however	RB
cord-001835-0s7ok4uw	4339	2	,	,	,
cord-001835-0s7ok4uw	4339	3	the	the	DT
cord-001835-0s7ok4uw	4339	4	synthesis	synthesis	NN
cord-001835-0s7ok4uw	4339	5	of	of	IN
cord-001835-0s7ok4uw	4339	6	site	site	NN
cord-001835-0s7ok4uw	4339	7	-	-	HYPH
cord-001835-0s7ok4uw	4339	8	specific	specific	JJ
cord-001835-0s7ok4uw	4339	9	and	and	CC
cord-001835-0s7ok4uw	4339	10	stoichiometric	stoichiometric	JJ
cord-001835-0s7ok4uw	4339	11	protein	protein	NN
cord-001835-0s7ok4uw	4339	12	-	-	HYPH
cord-001835-0s7ok4uw	4339	13	DNA	dna	NN
cord-001835-0s7ok4uw	4339	14	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	4339	15	can	can	MD
cord-001835-0s7ok4uw	4339	16	be	be	VB
cord-001835-0s7ok4uw	4339	17	challenging	challenging	JJ
cord-001835-0s7ok4uw	4339	18	.	.	.
cord-001835-0s7ok4uw	4340	1	Due	due	IN
cord-001835-0s7ok4uw	4340	2	to	to	IN
cord-001835-0s7ok4uw	4340	3	the	the	DT
cord-001835-0s7ok4uw	4340	4	diversity	diversity	NN
cord-001835-0s7ok4uw	4340	5	in	in	IN
cord-001835-0s7ok4uw	4340	6	composition	composition	NN
cord-001835-0s7ok4uw	4340	7	and	and	CC
cord-001835-0s7ok4uw	4340	8	physico	physico	NN
cord-001835-0s7ok4uw	4340	9	-	-	HYPH
cord-001835-0s7ok4uw	4340	10	chemical	chemical	NN
cord-001835-0s7ok4uw	4340	11	properties	property	NNS
cord-001835-0s7ok4uw	4340	12	of	of	IN
cord-001835-0s7ok4uw	4340	13	the	the	DT
cord-001835-0s7ok4uw	4340	14	proteins	protein	NNS
cord-001835-0s7ok4uw	4340	15	,	,	,
cord-001835-0s7ok4uw	4340	16	few	few	JJ
cord-001835-0s7ok4uw	4340	17	generic	generic	JJ
cord-001835-0s7ok4uw	4340	18	strategies	strategy	NNS
cord-001835-0s7ok4uw	4340	19	are	be	VBP
cord-001835-0s7ok4uw	4340	20	available	available	JJ
cord-001835-0s7ok4uw	4340	21	for	for	IN
cord-001835-0s7ok4uw	4340	22	conjugation	conjugation	NN
cord-001835-0s7ok4uw	4340	23	of	of	IN
cord-001835-0s7ok4uw	4340	24	protein	protein	NN
cord-001835-0s7ok4uw	4340	25	molecules	molecule	NNS
cord-001835-0s7ok4uw	4340	26	to	to	IN
cord-001835-0s7ok4uw	4340	27	a	a	DT
cord-001835-0s7ok4uw	4340	28	DNA	dna	NN
cord-001835-0s7ok4uw	4340	29	scaffold	scaffold	NN
cord-001835-0s7ok4uw	4340	30	.	.	.
cord-001835-0s7ok4uw	4341	1	A	a	DT
cord-001835-0s7ok4uw	4341	2	common	common	JJ
cord-001835-0s7ok4uw	4341	3	approach	approach	NN
cord-001835-0s7ok4uw	4341	4	is	be	VBZ
cord-001835-0s7ok4uw	4341	5	to	to	TO
cord-001835-0s7ok4uw	4341	6	use	use	VB
cord-001835-0s7ok4uw	4341	7	thiol	thiol	NN
cord-001835-0s7ok4uw	4341	8	-	-	HYPH
cord-001835-0s7ok4uw	4341	9	based	base	VBN
cord-001835-0s7ok4uw	4341	10	covalent	covalent	JJ
cord-001835-0s7ok4uw	4341	11	conjugation	conjugation	NN
cord-001835-0s7ok4uw	4341	12	,	,	,
cord-001835-0s7ok4uw	4341	13	but	but	CC
cord-001835-0s7ok4uw	4341	14	the	the	DT
cord-001835-0s7ok4uw	4341	15	introduction	introduction	NN
cord-001835-0s7ok4uw	4341	16	of	of	IN
cord-001835-0s7ok4uw	4341	17	additional	additional	JJ
cord-001835-0s7ok4uw	4341	18	cysteines	cysteine	NNS
cord-001835-0s7ok4uw	4341	19	can	can	MD
cord-001835-0s7ok4uw	4341	20	lead	lead	VB
cord-001835-0s7ok4uw	4341	21	to	to	IN
cord-001835-0s7ok4uw	4341	22	the	the	DT
cord-001835-0s7ok4uw	4341	23	formation	formation	NN
cord-001835-0s7ok4uw	4341	24	of	of	IN
cord-001835-0s7ok4uw	4341	25	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	4341	26	disulfides	disulfide	NNS
cord-001835-0s7ok4uw	4341	27	or	or	CC
cord-001835-0s7ok4uw	4341	28	interfere	interfere	VB
cord-001835-0s7ok4uw	4341	29	with	with	IN
cord-001835-0s7ok4uw	4341	30	the	the	DT
cord-001835-0s7ok4uw	4341	31	formation	formation	NN
cord-001835-0s7ok4uw	4341	32	of	of	IN
cord-001835-0s7ok4uw	4341	33	native	native	JJ
cord-001835-0s7ok4uw	4341	34	disulfide	disulfide	NN
cord-001835-0s7ok4uw	4341	35	bonds	bond	NNS
cord-001835-0s7ok4uw	4341	36	.	.	.
cord-001835-0s7ok4uw	4342	1	As	as	IN
cord-001835-0s7ok4uw	4342	2	an	an	DT
cord-001835-0s7ok4uw	4342	3	alternative	alternative	NN
cord-001835-0s7ok4uw	4342	4	,	,	,
cord-001835-0s7ok4uw	4342	5	here	here	RB
cord-001835-0s7ok4uw	4342	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	4342	7	have	have	VBP
cord-001835-0s7ok4uw	4342	8	developed	develop	VBN
cord-001835-0s7ok4uw	4342	9	a	a	DT
cord-001835-0s7ok4uw	4342	10	site	site	NN
cord-001835-0s7ok4uw	4342	11	-	-	HYPH
cord-001835-0s7ok4uw	4342	12	directed	direct	VBN
cord-001835-0s7ok4uw	4342	13	protein	protein	NN
cord-001835-0s7ok4uw	4342	14	-	-	HYPH
cord-001835-0s7ok4uw	4342	15	DNA	dna	NN
cord-001835-0s7ok4uw	4342	16	conjugation	conjugation	NN
cord-001835-0s7ok4uw	4342	17	strategy	strategy	NN
cord-001835-0s7ok4uw	4342	18	based	base	VBN
cord-001835-0s7ok4uw	4342	19	on	on	IN
cord-001835-0s7ok4uw	4342	20	sortase	sortase	NNP
cord-001835-0s7ok4uw	4342	21	mediated	mediate	VBN
cord-001835-0s7ok4uw	4342	22	trans	trans	NNP
cord-001835-0s7ok4uw	4342	23	-	-	JJ
cord-001835-0s7ok4uw	4342	24	peptidation	peptidation	JJ
cord-001835-0s7ok4uw	4342	25	reaction	reaction	NN
cord-001835-0s7ok4uw	4342	26	.	.	.
cord-001835-0s7ok4uw	4343	1	The	the	DT
cord-001835-0s7ok4uw	4343	2	sortase	sortase	NN
cord-001835-0s7ok4uw	4343	3	recognizes	recognize	VBZ
cord-001835-0s7ok4uw	4343	4	a	a	DT
cord-001835-0s7ok4uw	4343	5	'	'	``
cord-001835-0s7ok4uw	4343	6	sorting	sorting	NN
cord-001835-0s7ok4uw	4343	7	motif	motif	NN
cord-001835-0s7ok4uw	4343	8	'	'	''
cord-001835-0s7ok4uw	4343	9	(	(	-LRB-
cord-001835-0s7ok4uw	4343	10	i.e.	i.e.	FW
cord-001835-0s7ok4uw	4343	11	LPXTG	LPXTG	NNP
cord-001835-0s7ok4uw	4343	12	,	,	,
cord-001835-0s7ok4uw	4344	1	X	X	NFP
cord-001835-0s7ok4uw	4344	2	any	any	DT
cord-001835-0s7ok4uw	4344	3	amino	amino	NN
cord-001835-0s7ok4uw	4344	4	acid	acid	NN
cord-001835-0s7ok4uw	4344	5	)	)	-RRB-
cord-001835-0s7ok4uw	4344	6	,	,	,
cord-001835-0s7ok4uw	4344	7	which	which	WDT
cord-001835-0s7ok4uw	4344	8	is	be	VBZ
cord-001835-0s7ok4uw	4344	9	recombinantly	recombinantly	RB
cord-001835-0s7ok4uw	4344	10	introduced	introduce	VBN
cord-001835-0s7ok4uw	4344	11	by	by	IN
cord-001835-0s7ok4uw	4344	12	site	site	NN
cord-001835-0s7ok4uw	4344	13	-	-	HYPH
cord-001835-0s7ok4uw	4344	14	directed	direct	VBN
cord-001835-0s7ok4uw	4344	15	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	4344	16	at	at	IN
cord-001835-0s7ok4uw	4344	17	the	the	DT
cord-001835-0s7ok4uw	4344	18	Cterminal	Cterminal	NNP
cord-001835-0s7ok4uw	4344	19	end	end	NN
cord-001835-0s7ok4uw	4344	20	of	of	IN
cord-001835-0s7ok4uw	4344	21	the	the	DT
cord-001835-0s7ok4uw	4344	22	protein	protein	NN
cord-001835-0s7ok4uw	4344	23	molecule	molecule	NN
cord-001835-0s7ok4uw	4344	24	.	.	.
cord-001835-0s7ok4uw	4345	1	The	the	DT
cord-001835-0s7ok4uw	4345	2	sortase	sortase	NN
cord-001835-0s7ok4uw	4345	3	cleaves	cleave	VBZ
cord-001835-0s7ok4uw	4345	4	the	the	DT
cord-001835-0s7ok4uw	4345	5	T	T	NNP
cord-001835-0s7ok4uw	4345	6	-	-	HYPH
cord-001835-0s7ok4uw	4345	7	G	g	NN
cord-001835-0s7ok4uw	4345	8	peptide	peptide	NN
cord-001835-0s7ok4uw	4345	9	bond	bond	NN
cord-001835-0s7ok4uw	4345	10	and	and	CC
cord-001835-0s7ok4uw	4345	11	catalyzed	catalyze	VBD
cord-001835-0s7ok4uw	4345	12	the	the	DT
cord-001835-0s7ok4uw	4345	13	formation	formation	NN
cord-001835-0s7ok4uw	4345	14	of	of	IN
cord-001835-0s7ok4uw	4345	15	a	a	DT
cord-001835-0s7ok4uw	4345	16	new	new	JJ
cord-001835-0s7ok4uw	4345	17	amide	amide	NN
cord-001835-0s7ok4uw	4345	18	bond	bond	NN
cord-001835-0s7ok4uw	4345	19	between	between	IN
cord-001835-0s7ok4uw	4345	20	the	the	DT
cord-001835-0s7ok4uw	4345	21	LPXT	LPXT	NNP
cord-001835-0s7ok4uw	4345	22	peptide	peptide	NN
cord-001835-0s7ok4uw	4345	23	and	and	CC
cord-001835-0s7ok4uw	4345	24	the	the	DT
cord-001835-0s7ok4uw	4345	25	N	n	CD
cord-001835-0s7ok4uw	4345	26	-	-	HYPH
cord-001835-0s7ok4uw	4345	27	terminal	terminal	NN
cord-001835-0s7ok4uw	4345	28	amine	amine	NN
cord-001835-0s7ok4uw	4345	29	of	of	IN
cord-001835-0s7ok4uw	4345	30	any	any	DT
cord-001835-0s7ok4uw	4345	31	molecule	molecule	NN
cord-001835-0s7ok4uw	4345	32	bearing	bear	VBG
cord-001835-0s7ok4uw	4345	33	an	an	DT
cord-001835-0s7ok4uw	4345	34	N	n	CD
cord-001835-0s7ok4uw	4345	35	-	-	HYPH
cord-001835-0s7ok4uw	4345	36	terminal	terminal	JJ
cord-001835-0s7ok4uw	4345	37	oligoglycine	oligoglycine	NN
cord-001835-0s7ok4uw	4345	38	motif	motif	NN
cord-001835-0s7ok4uw	4345	39	.	.	.
cord-001835-0s7ok4uw	4346	1	For	for	IN
cord-001835-0s7ok4uw	4346	2	this	this	DT
cord-001835-0s7ok4uw	4346	3	purpose	purpose	NN
cord-001835-0s7ok4uw	4346	4	,	,	,
cord-001835-0s7ok4uw	4346	5	a	a	DT
cord-001835-0s7ok4uw	4346	6	triglycine	triglycine	NN
cord-001835-0s7ok4uw	4346	7	motif	motif	NN
cord-001835-0s7ok4uw	4346	8	was	be	VBD
cord-001835-0s7ok4uw	4346	9	introduced	introduce	VBN
cord-001835-0s7ok4uw	4346	10	at	at	IN
cord-001835-0s7ok4uw	4346	11	the	the	DT
cord-001835-0s7ok4uw	4346	12	5'end	5'end	CD
cord-001835-0s7ok4uw	4346	13	of	of	IN
cord-001835-0s7ok4uw	4346	14	single	single	RB
cord-001835-0s7ok4uw	4346	15	-	-	HYPH
cord-001835-0s7ok4uw	4346	16	stranded	strand	VBN
cord-001835-0s7ok4uw	4346	17	DNA	dna	NN
cord-001835-0s7ok4uw	4346	18	(	(	-LRB-
cord-001835-0s7ok4uw	4346	19	ssDNA	ssdna	NN
cord-001835-0s7ok4uw	4346	20	)	)	-RRB-
cord-001835-0s7ok4uw	4346	21	.	.	.
cord-001835-0s7ok4uw	4347	1	On	on	IN
cord-001835-0s7ok4uw	4347	2	-	-	HYPH
cord-001835-0s7ok4uw	4347	3	column	column	NN
cord-001835-0s7ok4uw	4347	4	synthesis	synthesis	NN
cord-001835-0s7ok4uw	4347	5	of	of	IN
cord-001835-0s7ok4uw	4347	6	triglycine	triglycine	NN
cord-001835-0s7ok4uw	4347	7	modified	modify	VBN
cord-001835-0s7ok4uw	4347	8	ssDNA	ssdna	RB
cord-001835-0s7ok4uw	4347	9	,	,	,
cord-001835-0s7ok4uw	4347	10	protected	protect	VBN
cord-001835-0s7ok4uw	4347	11	on	on	IN
cord-001835-0s7ok4uw	4347	12	a	a	DT
cord-001835-0s7ok4uw	4347	13	controlled	control	VBN
cord-001835-0s7ok4uw	4347	14	pore	pore	NN
cord-001835-0s7ok4uw	4347	15	glass	glass	NN
cord-001835-0s7ok4uw	4347	16	beads	bead	NNS
cord-001835-0s7ok4uw	4347	17	,	,	,
cord-001835-0s7ok4uw	4347	18	simplified	simplify	VBD
cord-001835-0s7ok4uw	4347	19	the	the	DT
cord-001835-0s7ok4uw	4347	20	purification	purification	NN
cord-001835-0s7ok4uw	4347	21	process	process	NN
cord-001835-0s7ok4uw	4347	22	and	and	CC
cord-001835-0s7ok4uw	4347	23	enhanced	enhance	VBD
cord-001835-0s7ok4uw	4347	24	the	the	DT
cord-001835-0s7ok4uw	4347	25	yield	yield	NN
cord-001835-0s7ok4uw	4347	26	of	of	IN
cord-001835-0s7ok4uw	4347	27	triglycinemodified	triglycinemodified	JJ
cord-001835-0s7ok4uw	4347	28	ssDNA	ssdna	NN
cord-001835-0s7ok4uw	4347	29	(	(	-LRB-
cord-001835-0s7ok4uw	4347	30	>	>	NFP
cord-001835-0s7ok4uw	4347	31	90	90	CD
cord-001835-0s7ok4uw	4347	32	%	%	NN
cord-001835-0s7ok4uw	4347	33	)	)	-RRB-
cord-001835-0s7ok4uw	4347	34	.	.	.
cord-001835-0s7ok4uw	4348	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4348	2	used	use	VBD
cord-001835-0s7ok4uw	4348	3	this	this	DT
cord-001835-0s7ok4uw	4348	4	conjugation	conjugation	NN
cord-001835-0s7ok4uw	4348	5	strategy	strategy	NN
cord-001835-0s7ok4uw	4348	6	in	in	IN
cord-001835-0s7ok4uw	4348	7	several	several	JJ
cord-001835-0s7ok4uw	4348	8	biosensing	biosensing	NN
cord-001835-0s7ok4uw	4348	9	applications	application	NNS
cord-001835-0s7ok4uw	4348	10	.	.	.
cord-001835-0s7ok4uw	4349	1	For	for	IN
cord-001835-0s7ok4uw	4349	2	example	example	NN
cord-001835-0s7ok4uw	4349	3	,	,	,
cord-001835-0s7ok4uw	4349	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	4349	5	used	use	VBD
cord-001835-0s7ok4uw	4349	6	the	the	DT
cord-001835-0s7ok4uw	4349	7	method	method	NN
cord-001835-0s7ok4uw	4349	8	to	to	TO
cord-001835-0s7ok4uw	4349	9	conjugate	conjugate	VB
cord-001835-0s7ok4uw	4349	10	ssDNA	ssdna	NN
cord-001835-0s7ok4uw	4349	11	linkers	linker	NNS
cord-001835-0s7ok4uw	4349	12	at	at	IN
cord-001835-0s7ok4uw	4349	13	the	the	DT
cord-001835-0s7ok4uw	4349	14	C	C	NNP
cord-001835-0s7ok4uw	4349	15	-	-	HYPH
cord-001835-0s7ok4uw	4349	16	termini	termini	NNP
cord-001835-0s7ok4uw	4349	17	of	of	IN
cord-001835-0s7ok4uw	4349	18	a	a	DT
cord-001835-0s7ok4uw	4349	19	range	range	NN
cord-001835-0s7ok4uw	4349	20	of	of	IN
cord-001835-0s7ok4uw	4349	21	single	single	JJ
cord-001835-0s7ok4uw	4349	22	-	-	HYPH
cord-001835-0s7ok4uw	4349	23	chain	chain	NN
cord-001835-0s7ok4uw	4349	24	antibody	antibody	NN
cord-001835-0s7ok4uw	4349	25	fragments	fragment	NNS
cord-001835-0s7ok4uw	4349	26	(	(	-LRB-
cord-001835-0s7ok4uw	4349	27	scFv	scFv	NNP
cord-001835-0s7ok4uw	4349	28	)	)	-RRB-
cord-001835-0s7ok4uw	4349	29	and	and	CC
cord-001835-0s7ok4uw	4349	30	applied	apply	VBD
cord-001835-0s7ok4uw	4349	31	these	these	DT
cord-001835-0s7ok4uw	4349	32	constructs	construct	NNS
cord-001835-0s7ok4uw	4349	33	to	to	TO
cord-001835-0s7ok4uw	4349	34	allow	allow	VB
cord-001835-0s7ok4uw	4349	35	oriented	oriented	JJ
cord-001835-0s7ok4uw	4349	36	display	display	NN
cord-001835-0s7ok4uw	4349	37	of	of	IN
cord-001835-0s7ok4uw	4349	38	capture	capture	NN
cord-001835-0s7ok4uw	4349	39	molecules	molecule	NNS
cord-001835-0s7ok4uw	4349	40	on	on	IN
cord-001835-0s7ok4uw	4349	41	biosensor	biosensor	NN
cord-001835-0s7ok4uw	4349	42	surfaces	surface	NNS
cord-001835-0s7ok4uw	4349	43	.	.	.
cord-001835-0s7ok4uw	4350	1	ssDNA	ssDNA	NNP
cord-001835-0s7ok4uw	4351	1	-scFv	-scFv	:
cord-001835-0s7ok4uw	4351	2	were	be	VBD
cord-001835-0s7ok4uw	4351	3	Using	use	VBG
cord-001835-0s7ok4uw	4351	4	an	an	DT
cord-001835-0s7ok4uw	4351	5	excess	excess	NN
cord-001835-0s7ok4uw	4351	6	of	of	IN
cord-001835-0s7ok4uw	4351	7	triglycine	triglycine	NN
cord-001835-0s7ok4uw	4351	8	modified	modify	VBN
cord-001835-0s7ok4uw	4351	9	ssDNA	ssdna	RB
cord-001835-0s7ok4uw	4351	10	,	,	,
cord-001835-0s7ok4uw	4351	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	4351	12	achieved	achieve	VBD
cord-001835-0s7ok4uw	4351	13	55	55	CD
cord-001835-0s7ok4uw	4351	14	%	%	NN
cord-001835-0s7ok4uw	4351	15	conversion	conversion	NN
cord-001835-0s7ok4uw	4352	1	scFv	scFv	NNP
cord-001835-0s7ok4uw	4352	2	-	-	HYPH
cord-001835-0s7ok4uw	4352	3	ssDNA	ssdna	NN
cord-001835-0s7ok4uw	4352	4	conjugate	conjugate	NN
cord-001835-0s7ok4uw	4352	5	,	,	,
cord-001835-0s7ok4uw	4352	6	which	which	WDT
cord-001835-0s7ok4uw	4352	7	can	can	MD
cord-001835-0s7ok4uw	4352	8	be	be	VB
cord-001835-0s7ok4uw	4352	9	further	further	RB
cord-001835-0s7ok4uw	4352	10	purified	purify	VBN
cord-001835-0s7ok4uw	4352	11	by	by	IN
cord-001835-0s7ok4uw	4352	12	in	in	IN
cord-001835-0s7ok4uw	4352	13	two	two	CD
cord-001835-0s7ok4uw	4352	14	step	step	NN
cord-001835-0s7ok4uw	4352	15	purification	purification	NN
cord-001835-0s7ok4uw	4352	16	process	process	NN
cord-001835-0s7ok4uw	4352	17	consisting	consist	VBG
cord-001835-0s7ok4uw	4352	18	of	of	IN
cord-001835-0s7ok4uw	4352	19	Ni	Ni	NNP
cord-001835-0s7ok4uw	4352	20	-	-	HYPH
cord-001835-0s7ok4uw	4352	21	NTA	NTA	NNP
cord-001835-0s7ok4uw	4352	22	affinity	affinity	NN
cord-001835-0s7ok4uw	4352	23	column	column	NN
cord-001835-0s7ok4uw	4352	24	and	and	CC
cord-001835-0s7ok4uw	4352	25	ion	ion	NN
cord-001835-0s7ok4uw	4352	26	-	-	HYPH
cord-001835-0s7ok4uw	4352	27	exchange	exchange	NN
cord-001835-0s7ok4uw	4352	28	chromatography	chromatography	NN
cord-001835-0s7ok4uw	4352	29	.	.	.
cord-001835-0s7ok4uw	4353	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4353	2	also	also	RB
cord-001835-0s7ok4uw	4353	3	extended	extend	VBD
cord-001835-0s7ok4uw	4353	4	this	this	DT
cord-001835-0s7ok4uw	4353	5	sortase	sortase	NN
cord-001835-0s7ok4uw	4353	6	-	-	HYPH
cord-001835-0s7ok4uw	4353	7	based	base	VBN
cord-001835-0s7ok4uw	4353	8	conjugation	conjugation	NN
cord-001835-0s7ok4uw	4353	9	strategy	strategy	NN
cord-001835-0s7ok4uw	4353	10	to	to	TO
cord-001835-0s7ok4uw	4353	11	develop	develop	VB
cord-001835-0s7ok4uw	4353	12	a	a	DT
cord-001835-0s7ok4uw	4353	13	bioluminescence	bioluminescence	NN
cord-001835-0s7ok4uw	4353	14	based	base	VBN
cord-001835-0s7ok4uw	4353	15	assay	assay	NN
cord-001835-0s7ok4uw	4353	16	for	for	IN
cord-001835-0s7ok4uw	4353	17	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	4353	18	target	target	NN
cord-001835-0s7ok4uw	4353	19	oligonucleotide	oligonucleotide	IN
cord-001835-0s7ok4uw	4353	20	detection	detection	NN
cord-001835-0s7ok4uw	4353	21	.	.	.
cord-001835-0s7ok4uw	4354	1	In	in	IN
cord-001835-0s7ok4uw	4354	2	this	this	DT
cord-001835-0s7ok4uw	4354	3	regard	regard	NN
cord-001835-0s7ok4uw	4354	4	,	,	,
cord-001835-0s7ok4uw	4354	5	the	the	DT
cord-001835-0s7ok4uw	4354	6	5	5	CD
cord-001835-0s7ok4uw	4354	7	'	'	''
cord-001835-0s7ok4uw	4354	8	and	and	CC
cord-001835-0s7ok4uw	4354	9	3	3	CD
cord-001835-0s7ok4uw	4354	10	'	'	''
cord-001835-0s7ok4uw	4354	11	end	end	VB
cord-001835-0s7ok4uw	4354	12	triglycine	triglycine	NN
cord-001835-0s7ok4uw	4354	13	-	-	HYPH
cord-001835-0s7ok4uw	4354	14	modified	modify	VBN
cord-001835-0s7ok4uw	4354	15	ssDNA	ssdna	NN
cord-001835-0s7ok4uw	4354	16	molecules	molecule	NNS
cord-001835-0s7ok4uw	4354	17	were	be	VBD
cord-001835-0s7ok4uw	4354	18	successfully	successfully	RB
cord-001835-0s7ok4uw	4354	19	conjugated	conjugate	VBN
cord-001835-0s7ok4uw	4354	20	with	with	IN
cord-001835-0s7ok4uw	4354	21	a	a	DT
cord-001835-0s7ok4uw	4354	22	BRET	BRET	NNP
cord-001835-0s7ok4uw	4354	23	protein	protein	NN
cord-001835-0s7ok4uw	4354	24	pairs	pair	NNS
cord-001835-0s7ok4uw	4354	25	,	,	,
cord-001835-0s7ok4uw	4354	26	NanoLuc	NanoLuc	NNP
cord-001835-0s7ok4uw	4354	27	luciferase	luciferase	NN
cord-001835-0s7ok4uw	4354	28	and	and	CC
cord-001835-0s7ok4uw	4354	29	mNeonGreen	mneongreen	JJ
cord-001835-0s7ok4uw	4354	30	fluorescent	fluorescent	NN
cord-001835-0s7ok4uw	4354	31	protein	protein	NN
cord-001835-0s7ok4uw	4354	32	.	.	.
cord-001835-0s7ok4uw	4355	1	The	the	DT
cord-001835-0s7ok4uw	4355	2	introduction	introduction	NN
cord-001835-0s7ok4uw	4355	3	of	of	IN
cord-001835-0s7ok4uw	4355	4	a	a	DT
cord-001835-0s7ok4uw	4355	5	C	c	NN
cord-001835-0s7ok4uw	4355	6	-	-	HYPH
cord-001835-0s7ok4uw	4355	7	terminal	terminal	NN
cord-001835-0s7ok4uw	4355	8	sortase	sortase	NNP
cord-001835-0s7ok4uw	4355	9	-	-	HYPH
cord-001835-0s7ok4uw	4355	10	His5	His5	NNP
cord-001835-0s7ok4uw	4355	11	tag	tag	NN
cord-001835-0s7ok4uw	4355	12	and	and	CC
cord-001835-0s7ok4uw	4355	13	and	and	CC
cord-001835-0s7ok4uw	4355	14	N	n	CD
cord-001835-0s7ok4uw	4355	15	-	-	HYPH
cord-001835-0s7ok4uw	4355	16	terminal	terminal	JJ
cord-001835-0s7ok4uw	4355	17	Strep	Strep	NNP
cord-001835-0s7ok4uw	4355	18	-	-	HYPH
cord-001835-0s7ok4uw	4355	19	tag	tag	NN
cord-001835-0s7ok4uw	4355	20	allowed	allow	VBD
cord-001835-0s7ok4uw	4355	21	efficient	efficient	JJ
cord-001835-0s7ok4uw	4355	22	purification	purification	NN
cord-001835-0s7ok4uw	4355	23	of	of	IN
cord-001835-0s7ok4uw	4355	24	theseprotein	theseprotein	NNP
cord-001835-0s7ok4uw	4355	25	-	-	HYPH
cord-001835-0s7ok4uw	4355	26	ssDNA	ssdna	NN
cord-001835-0s7ok4uw	4355	27	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	4355	28	from	from	IN
cord-001835-0s7ok4uw	4355	29	excess	excess	JJ
cord-001835-0s7ok4uw	4355	30	oligonucleotides	oligonucleotide	NNS
cord-001835-0s7ok4uw	4355	31	and	and	CC
cord-001835-0s7ok4uw	4355	32	unreacted	unreacted	JJ
cord-001835-0s7ok4uw	4355	33	protein	protein	NN
cord-001835-0s7ok4uw	4355	34	.	.	.
cord-001835-0s7ok4uw	4356	1	Mass	mass	NN
cord-001835-0s7ok4uw	4356	2	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4356	3	based	base	VBN
cord-001835-0s7ok4uw	4356	4	proteomics	proteomic	NNS
cord-001835-0s7ok4uw	4356	5	to	to	TO
cord-001835-0s7ok4uw	4356	6	identify	identify	VB
cord-001835-0s7ok4uw	4356	7	the	the	DT
cord-001835-0s7ok4uw	4356	8	protein	protein	NN
cord-001835-0s7ok4uw	4356	9	differences	difference	NNS
cord-001835-0s7ok4uw	4356	10	in	in	IN
cord-001835-0s7ok4uw	4356	11	human	human	JJ
cord-001835-0s7ok4uw	4356	12	breast	breast	NN
cord-001835-0s7ok4uw	4356	13	milk	milk	NN
cord-001835-0s7ok4uw	4356	14	from	from	IN
cord-001835-0s7ok4uw	4356	15	breast	breast	NN
cord-001835-0s7ok4uw	4356	16	cancer	cancer	NN
cord-001835-0s7ok4uw	4356	17	patients	patient	NNS
cord-001835-0s7ok4uw	4356	18	and	and	CC
cord-001835-0s7ok4uw	4356	19	controls	control	VBZ
cord-001835-0s7ok4uw	4356	20	Devika	Devika	NNP
cord-001835-0s7ok4uw	4356	21	Channaveerappa	Channaveerappa	NNP
cord-001835-0s7ok4uw	4356	22	1	1	CD
cord-001835-0s7ok4uw	4356	23	,	,	,
cord-001835-0s7ok4uw	4356	24	Roshanak	Roshanak	NNP
cord-001835-0s7ok4uw	4356	25	Aslebagh	Aslebagh	NNP
cord-001835-0s7ok4uw	4356	26	1	1	CD
cord-001835-0s7ok4uw	4356	27	,	,	,
cord-001835-0s7ok4uw	4356	28	Kathleen	Kathleen	NNP
cord-001835-0s7ok4uw	4356	29	F.	F.	NNP
cord-001835-0s7ok4uw	4356	30	Arcaro	Arcaro	NNP
cord-001835-0s7ok4uw	4356	31	2	2	CD
cord-001835-0s7ok4uw	4357	1	,	,	,
cord-001835-0s7ok4uw	4357	2	Costel	Costel	NNP
cord-001835-0s7ok4uw	4357	3	C.	C.	NNP
cord-001835-0s7ok4uw	4357	4	Darie	Darie	NNP
cord-001835-0s7ok4uw	4357	5	1	1	CD
cord-001835-0s7ok4uw	4358	1	1	1	CD
cord-001835-0s7ok4uw	4358	2	Breast	breast	NN
cord-001835-0s7ok4uw	4358	3	cancer	cancer	NN
cord-001835-0s7ok4uw	4358	4	is	be	VBZ
cord-001835-0s7ok4uw	4358	5	the	the	DT
cord-001835-0s7ok4uw	4358	6	second	second	JJ
cord-001835-0s7ok4uw	4358	7	leading	leading	JJ
cord-001835-0s7ok4uw	4358	8	cause	cause	NN
cord-001835-0s7ok4uw	4358	9	of	of	IN
cord-001835-0s7ok4uw	4358	10	cancer	cancer	NN
cord-001835-0s7ok4uw	4358	11	death	death	NN
cord-001835-0s7ok4uw	4358	12	in	in	IN
cord-001835-0s7ok4uw	4358	13	women	woman	NNS
cord-001835-0s7ok4uw	4358	14	.	.	.
cord-001835-0s7ok4uw	4359	1	About	about	RB
cord-001835-0s7ok4uw	4359	2	12	12	CD
cord-001835-0s7ok4uw	4359	3	%	%	NN
cord-001835-0s7ok4uw	4359	4	women	woman	NNS
cord-001835-0s7ok4uw	4359	5	in	in	IN
cord-001835-0s7ok4uw	4359	6	the	the	DT
cord-001835-0s7ok4uw	4359	7	US	US	NNP
cord-001835-0s7ok4uw	4359	8	develop	develop	VB
cord-001835-0s7ok4uw	4359	9	breast	breast	NN
cord-001835-0s7ok4uw	4359	10	cancer	cancer	NN
cord-001835-0s7ok4uw	4359	11	.	.	.
cord-001835-0s7ok4uw	4360	1	Death	death	NN
cord-001835-0s7ok4uw	4360	2	rates	rate	NNS
cord-001835-0s7ok4uw	4360	3	due	due	JJ
cord-001835-0s7ok4uw	4360	4	to	to	IN
cord-001835-0s7ok4uw	4360	5	breast	breast	NN
cord-001835-0s7ok4uw	4360	6	cancer	cancer	NN
cord-001835-0s7ok4uw	4360	7	have	have	VBP
cord-001835-0s7ok4uw	4360	8	been	be	VBN
cord-001835-0s7ok4uw	4360	9	declined	decline	VBN
cord-001835-0s7ok4uw	4360	10	over	over	IN
cord-001835-0s7ok4uw	4360	11	the	the	DT
cord-001835-0s7ok4uw	4360	12	years	year	NNS
cord-001835-0s7ok4uw	4360	13	due	due	IN
cord-001835-0s7ok4uw	4360	14	to	to	IN
cord-001835-0s7ok4uw	4360	15	advancements	advancement	NNS
cord-001835-0s7ok4uw	4360	16	in	in	IN
cord-001835-0s7ok4uw	4360	17	mammography	mammography	NN
cord-001835-0s7ok4uw	4360	18	and	and	CC
cord-001835-0s7ok4uw	4360	19	treatment	treatment	NN
cord-001835-0s7ok4uw	4360	20	.	.	.
cord-001835-0s7ok4uw	4361	1	Although	although	IN
cord-001835-0s7ok4uw	4361	2	,	,	,
cord-001835-0s7ok4uw	4361	3	mammography	mammography	NN
cord-001835-0s7ok4uw	4361	4	helps	help	VBZ
cord-001835-0s7ok4uw	4361	5	in	in	IN
cord-001835-0s7ok4uw	4361	6	the	the	DT
cord-001835-0s7ok4uw	4361	7	early	early	JJ
cord-001835-0s7ok4uw	4361	8	detection	detection	NN
cord-001835-0s7ok4uw	4361	9	of	of	IN
cord-001835-0s7ok4uw	4361	10	breast	breast	NN
cord-001835-0s7ok4uw	4361	11	cancer	cancer	NN
cord-001835-0s7ok4uw	4361	12	,	,	,
cord-001835-0s7ok4uw	4361	13	it	-PRON-	PRP
cord-001835-0s7ok4uw	4361	14	has	have	VBZ
cord-001835-0s7ok4uw	4361	15	few	few	JJ
cord-001835-0s7ok4uw	4361	16	limitations	limitation	NNS
cord-001835-0s7ok4uw	4361	17	.	.	.
cord-001835-0s7ok4uw	4362	1	Dense	dense	JJ
cord-001835-0s7ok4uw	4362	2	breast	breast	NN
cord-001835-0s7ok4uw	4362	3	tissue	tissue	NN
cord-001835-0s7ok4uw	4362	4	makes	make	VBZ
cord-001835-0s7ok4uw	4362	5	mammogram	mammogram	NN
cord-001835-0s7ok4uw	4362	6	less	less	RBR
cord-001835-0s7ok4uw	4362	7	accurate	accurate	JJ
cord-001835-0s7ok4uw	4362	8	.	.	.
cord-001835-0s7ok4uw	4363	1	Breast	breast	NN
cord-001835-0s7ok4uw	4363	2	milk	milk	NN
cord-001835-0s7ok4uw	4363	3	can	can	MD
cord-001835-0s7ok4uw	4363	4	be	be	VB
cord-001835-0s7ok4uw	4363	5	assessed	assess	VBN
cord-001835-0s7ok4uw	4363	6	to	to	TO
cord-001835-0s7ok4uw	4363	7	evaluate	evaluate	VB
cord-001835-0s7ok4uw	4363	8	the	the	DT
cord-001835-0s7ok4uw	4363	9	risk	risk	NN
cord-001835-0s7ok4uw	4363	10	of	of	IN
cord-001835-0s7ok4uw	4363	11	one	one	CD
cord-001835-0s7ok4uw	4363	12	getting	get	VBG
cord-001835-0s7ok4uw	4363	13	breast	breast	NN
cord-001835-0s7ok4uw	4363	14	cancer	cancer	NN
cord-001835-0s7ok4uw	4363	15	by	by	IN
cord-001835-0s7ok4uw	4363	16	comparing	compare	VBG
cord-001835-0s7ok4uw	4363	17	the	the	DT
cord-001835-0s7ok4uw	4363	18	proteomes	proteome	NNS
cord-001835-0s7ok4uw	4363	19	of	of	IN
cord-001835-0s7ok4uw	4363	20	breast	breast	NN
cord-001835-0s7ok4uw	4363	21	milk	milk	NN
cord-001835-0s7ok4uw	4363	22	from	from	IN
cord-001835-0s7ok4uw	4363	23	healthy	healthy	JJ
cord-001835-0s7ok4uw	4363	24	and	and	CC
cord-001835-0s7ok4uw	4363	25	breast	breast	NN
cord-001835-0s7ok4uw	4363	26	cancer	cancer	NN
cord-001835-0s7ok4uw	4363	27	suffering	suffer	VBG
cord-001835-0s7ok4uw	4363	28	individual	individual	JJ
cord-001835-0s7ok4uw	4363	29	.	.	.
cord-001835-0s7ok4uw	4364	1	This	this	DT
cord-001835-0s7ok4uw	4364	2	study	study	NN
cord-001835-0s7ok4uw	4364	3	makes	make	VBZ
cord-001835-0s7ok4uw	4364	4	use	use	NN
cord-001835-0s7ok4uw	4364	5	of	of	IN
cord-001835-0s7ok4uw	4364	6	mass	mass	NN
cord-001835-0s7ok4uw	4364	7	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4364	8	based	base	VBN
cord-001835-0s7ok4uw	4364	9	proteomics	proteomic	NNS
cord-001835-0s7ok4uw	4364	10	to	to	TO
cord-001835-0s7ok4uw	4364	11	identify	identify	VB
cord-001835-0s7ok4uw	4364	12	the	the	DT
cord-001835-0s7ok4uw	4364	13	differences	difference	NNS
cord-001835-0s7ok4uw	4364	14	between	between	IN
cord-001835-0s7ok4uw	4364	15	the	the	DT
cord-001835-0s7ok4uw	4364	16	control	control	NN
cord-001835-0s7ok4uw	4364	17	and	and	CC
cord-001835-0s7ok4uw	4364	18	cancerous	cancerous	JJ
cord-001835-0s7ok4uw	4364	19	samples	sample	NNS
cord-001835-0s7ok4uw	4364	20	which	which	WDT
cord-001835-0s7ok4uw	4364	21	would	would	MD
cord-001835-0s7ok4uw	4364	22	further	further	RB
cord-001835-0s7ok4uw	4364	23	help	help	VB
cord-001835-0s7ok4uw	4364	24	in	in	IN
cord-001835-0s7ok4uw	4364	25	identifying	identify	VBG
cord-001835-0s7ok4uw	4364	26	potential	potential	JJ
cord-001835-0s7ok4uw	4364	27	biomarkers	biomarker	NNS
cord-001835-0s7ok4uw	4364	28	for	for	IN
cord-001835-0s7ok4uw	4364	29	breast	breast	NN
cord-001835-0s7ok4uw	4364	30	cancer	cancer	NN
cord-001835-0s7ok4uw	4364	31	.	.	.
cord-001835-0s7ok4uw	4365	1	Firstly	firstly	RB
cord-001835-0s7ok4uw	4365	2	,	,	,
cord-001835-0s7ok4uw	4365	3	SDS	SDS	NNP
cord-001835-0s7ok4uw	4365	4	-	-	HYPH
cord-001835-0s7ok4uw	4365	5	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	4365	6	was	be	VBD
cord-001835-0s7ok4uw	4365	7	used	use	VBN
cord-001835-0s7ok4uw	4365	8	to	to	TO
cord-001835-0s7ok4uw	4365	9	separate	separate	VB
cord-001835-0s7ok4uw	4365	10	the	the	DT
cord-001835-0s7ok4uw	4365	11	proteins	protein	NNS
cord-001835-0s7ok4uw	4365	12	from	from	IN
cord-001835-0s7ok4uw	4365	13	the	the	DT
cord-001835-0s7ok4uw	4365	14	whole	whole	JJ
cord-001835-0s7ok4uw	4365	15	milk	milk	NN
cord-001835-0s7ok4uw	4365	16	sample	sample	NN
cord-001835-0s7ok4uw	4365	17	.	.	.
cord-001835-0s7ok4uw	4366	1	The	the	DT
cord-001835-0s7ok4uw	4366	2	gel	gel	NN
cord-001835-0s7ok4uw	4366	3	bands	band	NNS
cord-001835-0s7ok4uw	4366	4	for	for	IN
cord-001835-0s7ok4uw	4366	5	each	each	DT
cord-001835-0s7ok4uw	4366	6	sample	sample	NN
cord-001835-0s7ok4uw	4366	7	was	be	VBD
cord-001835-0s7ok4uw	4366	8	then	then	RB
cord-001835-0s7ok4uw	4366	9	excised	excise	VBN
cord-001835-0s7ok4uw	4366	10	and	and	CC
cord-001835-0s7ok4uw	4366	11	cut	cut	VBN
cord-001835-0s7ok4uw	4366	12	into	into	IN
cord-001835-0s7ok4uw	4366	13	small	small	JJ
cord-001835-0s7ok4uw	4366	14	pieces	piece	NNS
cord-001835-0s7ok4uw	4366	15	.	.	.
cord-001835-0s7ok4uw	4367	1	The	the	DT
cord-001835-0s7ok4uw	4367	2	gel	gel	NN
cord-001835-0s7ok4uw	4367	3	pieces	piece	NNS
cord-001835-0s7ok4uw	4367	4	were	be	VBD
cord-001835-0s7ok4uw	4367	5	washed	wash	VBN
cord-001835-0s7ok4uw	4367	6	and	and	CC
cord-001835-0s7ok4uw	4367	7	trypsin	trypsin	NN
cord-001835-0s7ok4uw	4367	8	digested	digest	VBN
cord-001835-0s7ok4uw	4367	9	in	in	IN
cord-001835-0s7ok4uw	4367	10	order	order	NN
cord-001835-0s7ok4uw	4367	11	to	to	TO
cord-001835-0s7ok4uw	4367	12	extract	extract	VB
cord-001835-0s7ok4uw	4367	13	the	the	DT
cord-001835-0s7ok4uw	4367	14	peptides	peptide	NNS
cord-001835-0s7ok4uw	4367	15	.	.	.
cord-001835-0s7ok4uw	4368	1	Peptide	peptide	NN
cord-001835-0s7ok4uw	4368	2	mixtures	mixture	NNS
cord-001835-0s7ok4uw	4368	3	in	in	IN
cord-001835-0s7ok4uw	4368	4	the	the	DT
cord-001835-0s7ok4uw	4368	5	solution	solution	NN
cord-001835-0s7ok4uw	4368	6	were	be	VBD
cord-001835-0s7ok4uw	4368	7	cleaned	clean	VBN
cord-001835-0s7ok4uw	4368	8	using	use	VBG
cord-001835-0s7ok4uw	4368	9	C18	C18	NNP
cord-001835-0s7ok4uw	4368	10	Zip	Zip	NNP
cord-001835-0s7ok4uw	4368	11	-	-	HYPH
cord-001835-0s7ok4uw	4368	12	tipp	tipp	NNP
cord-001835-0s7ok4uw	4368	13	and	and	CC
cord-001835-0s7ok4uw	4368	14	then	then	RB
cord-001835-0s7ok4uw	4368	15	analyzed	analyze	VBN
cord-001835-0s7ok4uw	4368	16	by	by	IN
cord-001835-0s7ok4uw	4368	17	liquid	liquid	JJ
cord-001835-0s7ok4uw	4368	18	chromatography	chromatography	NN
cord-001835-0s7ok4uw	4368	19	-	-	HYPH
cord-001835-0s7ok4uw	4368	20	tandem	tandem	NN
cord-001835-0s7ok4uw	4368	21	mass	mass	NN
cord-001835-0s7ok4uw	4368	22	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4368	23	(	(	-LRB-
cord-001835-0s7ok4uw	4368	24	LC	LC	NNP
cord-001835-0s7ok4uw	4368	25	-	-	HYPH
cord-001835-0s7ok4uw	4368	26	MS	MS	NNP
cord-001835-0s7ok4uw	4368	27	/	/	SYM
cord-001835-0s7ok4uw	4368	28	MS	MS	NNP
cord-001835-0s7ok4uw	4368	29	)	)	-RRB-
cord-001835-0s7ok4uw	4368	30	.	.	.
cord-001835-0s7ok4uw	4369	1	60	60	CD
cord-001835-0s7ok4uw	4369	2	minutes	minute	NNS
cord-001835-0s7ok4uw	4369	3	and	and	CC
cord-001835-0s7ok4uw	4369	4	120	120	CD
cord-001835-0s7ok4uw	4369	5	minutes	minute	NNS
cord-001835-0s7ok4uw	4369	6	gradient	gradient	NN
cord-001835-0s7ok4uw	4369	7	were	be	VBD
cord-001835-0s7ok4uw	4369	8	used	use	VBN
cord-001835-0s7ok4uw	4369	9	for	for	IN
cord-001835-0s7ok4uw	4369	10	LC	LC	NNP
cord-001835-0s7ok4uw	4369	11	-	-	HYPH
cord-001835-0s7ok4uw	4369	12	MS	MS	NNP
cord-001835-0s7ok4uw	4369	13	/	/	SYM
cord-001835-0s7ok4uw	4369	14	MS	MS	NNP
cord-001835-0s7ok4uw	4369	15	analysis	analysis	NN
cord-001835-0s7ok4uw	4369	16	.	.	.
cord-001835-0s7ok4uw	4370	1	Raw	raw	JJ
cord-001835-0s7ok4uw	4370	2	data	datum	NNS
cord-001835-0s7ok4uw	4370	3	obtained	obtain	VBN
cord-001835-0s7ok4uw	4370	4	were	be	VBD
cord-001835-0s7ok4uw	4370	5	converted	convert	VBN
cord-001835-0s7ok4uw	4370	6	to	to	IN
cord-001835-0s7ok4uw	4370	7	pkl	pkl	NN
cord-001835-0s7ok4uw	4370	8	files	file	NNS
cord-001835-0s7ok4uw	4370	9	using	use	VBG
cord-001835-0s7ok4uw	4370	10	ProteinLynx	ProteinLynx	NNP
cord-001835-0s7ok4uw	4370	11	Global	Global	NNP
cord-001835-0s7ok4uw	4370	12	Served	Served	NNP
cord-001835-0s7ok4uw	4370	13	(	(	-LRB-
cord-001835-0s7ok4uw	4370	14	PLGS	PLGS	NNP
cord-001835-0s7ok4uw	4370	15	version	version	NN
cord-001835-0s7ok4uw	4370	16	2.4	2.4	CD
cord-001835-0s7ok4uw	4370	17	)	)	-RRB-
cord-001835-0s7ok4uw	4370	18	.	.	.
cord-001835-0s7ok4uw	4371	1	Raw	raw	JJ
cord-001835-0s7ok4uw	4371	2	data	datum	NNS
cord-001835-0s7ok4uw	4371	3	were	be	VBD
cord-001835-0s7ok4uw	4371	4	then	then	RB
cord-001835-0s7ok4uw	4371	5	submitted	submit	VBN
cord-001835-0s7ok4uw	4371	6	to	to	IN
cord-001835-0s7ok4uw	4371	7	Mascot	Mascot	NNP
cord-001835-0s7ok4uw	4371	8	database	database	NN
cord-001835-0s7ok4uw	4371	9	search	search	NN
cord-001835-0s7ok4uw	4371	10	for	for	IN
cord-001835-0s7ok4uw	4371	11	protein	protein	NN
cord-001835-0s7ok4uw	4371	12	identification	identification	NN
cord-001835-0s7ok4uw	4371	13	.	.	.
cord-001835-0s7ok4uw	4372	1	The	the	DT
cord-001835-0s7ok4uw	4372	2	Mascot	Mascot	NNP
cord-001835-0s7ok4uw	4372	3	results	result	NNS
cord-001835-0s7ok4uw	4372	4	were	be	VBD
cord-001835-0s7ok4uw	4372	5	then	then	RB
cord-001835-0s7ok4uw	4372	6	exported	export	VBN
cord-001835-0s7ok4uw	4372	7	as	as	IN
cord-001835-0s7ok4uw	4372	8	.dat	.dat	CD
cord-001835-0s7ok4uw	4372	9	files	file	NNS
cord-001835-0s7ok4uw	4372	10	and	and	CC
cord-001835-0s7ok4uw	4372	11	further	further	RB
cord-001835-0s7ok4uw	4372	12	analyzed	analyze	VBN
cord-001835-0s7ok4uw	4372	13	using	use	VBG
cord-001835-0s7ok4uw	4372	14	Scaffold	Scaffold	NNP
cord-001835-0s7ok4uw	4372	15	version	version	NN
cord-001835-0s7ok4uw	4372	16	4.1	4.1	CD
cord-001835-0s7ok4uw	4372	17	software	software	NN
cord-001835-0s7ok4uw	4372	18	.	.	.
cord-001835-0s7ok4uw	4373	1	Three	three	CD
cord-001835-0s7ok4uw	4373	2	breast	breast	NN
cord-001835-0s7ok4uw	4373	3	cancer	cancer	NN
cord-001835-0s7ok4uw	4373	4	milk	milk	NN
cord-001835-0s7ok4uw	4373	5	samples	sample	NNS
cord-001835-0s7ok4uw	4373	6	were	be	VBD
cord-001835-0s7ok4uw	4373	7	investigated	investigate	VBN
cord-001835-0s7ok4uw	4373	8	against	against	IN
cord-001835-0s7ok4uw	4373	9	healthy	healthy	JJ
cord-001835-0s7ok4uw	4373	10	control	control	NN
cord-001835-0s7ok4uw	4373	11	milk	milk	NN
cord-001835-0s7ok4uw	4373	12	samples	sample	NNS
cord-001835-0s7ok4uw	4373	13	.	.	.
cord-001835-0s7ok4uw	4374	1	In	in	IN
cord-001835-0s7ok4uw	4374	2	the	the	DT
cord-001835-0s7ok4uw	4374	3	SDS	SDS	NNP
cord-001835-0s7ok4uw	4374	4	-	-	HYPH
cord-001835-0s7ok4uw	4374	5	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	4374	6	gel	gel	NN
cord-001835-0s7ok4uw	4374	7	,	,	,
cord-001835-0s7ok4uw	4374	8	after	after	IN
cord-001835-0s7ok4uw	4374	9	Coomassie	coomassie	NN
cord-001835-0s7ok4uw	4374	10	staining	staining	NN
cord-001835-0s7ok4uw	4374	11	,	,	,
cord-001835-0s7ok4uw	4374	12	the	the	DT
cord-001835-0s7ok4uw	4374	13	protein	protein	NN
cord-001835-0s7ok4uw	4374	14	patterns	pattern	NNS
cord-001835-0s7ok4uw	4374	15	did	do	VBD
cord-001835-0s7ok4uw	4374	16	show	show	VB
cord-001835-0s7ok4uw	4374	17	minor	minor	JJ
cord-001835-0s7ok4uw	4374	18	differences	difference	NNS
cord-001835-0s7ok4uw	4374	19	.	.	.
cord-001835-0s7ok4uw	4375	1	After	after	IN
cord-001835-0s7ok4uw	4375	2	LC	LC	NNP
cord-001835-0s7ok4uw	4375	3	-	-	HYPH
cord-001835-0s7ok4uw	4375	4	MS	MS	NNP
cord-001835-0s7ok4uw	4375	5	/	/	SYM
cord-001835-0s7ok4uw	4375	6	MS	MS	NNP
cord-001835-0s7ok4uw	4375	7	analysis	analysis	NN
cord-001835-0s7ok4uw	4375	8	,	,	,
cord-001835-0s7ok4uw	4375	9	the	the	DT
cord-001835-0s7ok4uw	4375	10	proteins	protein	NNS
cord-001835-0s7ok4uw	4375	11	identified	identify	VBN
cord-001835-0s7ok4uw	4375	12	by	by	IN
cord-001835-0s7ok4uw	4375	13	Mascot	Mascot	NNP
cord-001835-0s7ok4uw	4375	14	database	database	NN
cord-001835-0s7ok4uw	4375	15	search	search	NN
cord-001835-0s7ok4uw	4375	16	were	be	VBD
cord-001835-0s7ok4uw	4375	17	imported	import	VBN
cord-001835-0s7ok4uw	4375	18	into	into	IN
cord-001835-0s7ok4uw	4375	19	the	the	DT
cord-001835-0s7ok4uw	4375	20	Scaffold	Scaffold	NNP
cord-001835-0s7ok4uw	4375	21	software	software	NN
cord-001835-0s7ok4uw	4375	22	and	and	CC
cord-001835-0s7ok4uw	4375	23	compared	compare	VBN
cord-001835-0s7ok4uw	4375	24	for	for	IN
cord-001835-0s7ok4uw	4375	25	the	the	DT
cord-001835-0s7ok4uw	4375	26	relative	relative	JJ
cord-001835-0s7ok4uw	4375	27	ratio	ratio	NN
cord-001835-0s7ok4uw	4375	28	between	between	IN
cord-001835-0s7ok4uw	4375	29	the	the	DT
cord-001835-0s7ok4uw	4375	30	proteins	protein	NNS
cord-001835-0s7ok4uw	4375	31	from	from	IN
cord-001835-0s7ok4uw	4375	32	the	the	DT
cord-001835-0s7ok4uw	4375	33	milk	milk	NN
cord-001835-0s7ok4uw	4375	34	sampled	sample	VBN
cord-001835-0s7ok4uw	4375	35	from	from	IN
cord-001835-0s7ok4uw	4375	36	control	control	NN
cord-001835-0s7ok4uw	4375	37	donors	donor	NNS
cord-001835-0s7ok4uw	4375	38	and	and	CC
cord-001835-0s7ok4uw	4375	39	the	the	DT
cord-001835-0s7ok4uw	4375	40	donors	donor	NNS
cord-001835-0s7ok4uw	4375	41	with	with	IN
cord-001835-0s7ok4uw	4375	42	breast	breast	NN
cord-001835-0s7ok4uw	4375	43	cancer	cancer	NN
cord-001835-0s7ok4uw	4375	44	.	.	.
cord-001835-0s7ok4uw	4376	1	There	there	EX
cord-001835-0s7ok4uw	4376	2	were	be	VBD
cord-001835-0s7ok4uw	4376	3	significant	significant	JJ
cord-001835-0s7ok4uw	4376	4	differences	difference	NNS
cord-001835-0s7ok4uw	4376	5	identified	identify	VBN
cord-001835-0s7ok4uw	4376	6	in	in	IN
cord-001835-0s7ok4uw	4376	7	the	the	DT
cord-001835-0s7ok4uw	4376	8	proteomes	proteome	NNS
cord-001835-0s7ok4uw	4376	9	of	of	IN
cord-001835-0s7ok4uw	4376	10	the	the	DT
cord-001835-0s7ok4uw	4376	11	two	two	CD
cord-001835-0s7ok4uw	4376	12	sets	set	NNS
cord-001835-0s7ok4uw	4376	13	of	of	IN
cord-001835-0s7ok4uw	4376	14	samples	sample	NNS
cord-001835-0s7ok4uw	4376	15	.	.	.
cord-001835-0s7ok4uw	4377	1	Some	some	DT
cord-001835-0s7ok4uw	4377	2	of	of	IN
cord-001835-0s7ok4uw	4377	3	the	the	DT
cord-001835-0s7ok4uw	4377	4	proteins	protein	NNS
cord-001835-0s7ok4uw	4377	5	were	be	VBD
cord-001835-0s7ok4uw	4377	6	upregulated	upregulate	VBN
cord-001835-0s7ok4uw	4377	7	in	in	IN
cord-001835-0s7ok4uw	4377	8	the	the	DT
cord-001835-0s7ok4uw	4377	9	breast	breast	NN
cord-001835-0s7ok4uw	4377	10	cancer	cancer	NN
cord-001835-0s7ok4uw	4377	11	samples	sample	NNS
cord-001835-0s7ok4uw	4377	12	and	and	CC
cord-001835-0s7ok4uw	4377	13	some	some	DT
cord-001835-0s7ok4uw	4377	14	were	be	VBD
cord-001835-0s7ok4uw	4377	15	down	down	RB
cord-001835-0s7ok4uw	4377	16	regulated	regulate	VBN
cord-001835-0s7ok4uw	4377	17	when	when	WRB
cord-001835-0s7ok4uw	4377	18	compared	compare	VBN
cord-001835-0s7ok4uw	4377	19	with	with	IN
cord-001835-0s7ok4uw	4377	20	the	the	DT
cord-001835-0s7ok4uw	4377	21	controls	control	NNS
cord-001835-0s7ok4uw	4377	22	.	.	.
cord-001835-0s7ok4uw	4378	1	Additional	additional	JJ
cord-001835-0s7ok4uw	4378	2	investigation	investigation	NN
cord-001835-0s7ok4uw	4378	3	of	of	IN
cord-001835-0s7ok4uw	4378	4	more	more	JJR
cord-001835-0s7ok4uw	4378	5	breast	breast	NN
cord-001835-0s7ok4uw	4378	6	milk	milk	NN
cord-001835-0s7ok4uw	4378	7	samples	sample	NNS
cord-001835-0s7ok4uw	4378	8	is	be	VBZ
cord-001835-0s7ok4uw	4378	9	ongoing	ongoing	JJ
cord-001835-0s7ok4uw	4378	10	.	.	.
cord-001835-0s7ok4uw	4379	1	This	this	DT
cord-001835-0s7ok4uw	4379	2	study	study	NN
cord-001835-0s7ok4uw	4379	3	focuses	focus	VBZ
cord-001835-0s7ok4uw	4379	4	on	on	IN
cord-001835-0s7ok4uw	4379	5	identifying	identify	VBG
cord-001835-0s7ok4uw	4379	6	biomarkers	biomarker	NNS
cord-001835-0s7ok4uw	4379	7	directly	directly	RB
cord-001835-0s7ok4uw	4379	8	in	in	IN
cord-001835-0s7ok4uw	4379	9	the	the	DT
cord-001835-0s7ok4uw	4379	10	milk	milk	NN
cord-001835-0s7ok4uw	4379	11	of	of	IN
cord-001835-0s7ok4uw	4379	12	donors	donor	NNS
cord-001835-0s7ok4uw	4379	13	with	with	IN
cord-001835-0s7ok4uw	4379	14	breast	breast	NN
cord-001835-0s7ok4uw	4379	15	cancer	cancer	NN
cord-001835-0s7ok4uw	4379	16	.	.	.
cord-001835-0s7ok4uw	4380	1	Leukolike	leukolike	IN
cord-001835-0s7ok4uw	4380	2	Vectors	vector	NNS
cord-001835-0s7ok4uw	4380	3	:	:	:
cord-001835-0s7ok4uw	4380	4	leukocyte	leukocyte	NN
cord-001835-0s7ok4uw	4380	5	-	-	HYPH
cord-001835-0s7ok4uw	4380	6	inspired	inspire	VBN
cord-001835-0s7ok4uw	4380	7	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	4380	8	Claudia	Claudia	NNP
cord-001835-0s7ok4uw	4380	9	Corbo	Corbo	NNP
cord-001835-0s7ok4uw	4380	10	1,2	1,2	CD
cord-001835-0s7ok4uw	4380	11	,	,	,
cord-001835-0s7ok4uw	4380	12	Alessandro	Alessandro	NNP
cord-001835-0s7ok4uw	4380	13	Parodi	Parodi	NNP
cord-001835-0s7ok4uw	4380	14	1,2	1,2	CD
cord-001835-0s7ok4uw	4380	15	,	,	,
cord-001835-0s7ok4uw	4380	16	Roberto	Roberto	NNP
cord-001835-0s7ok4uw	4380	17	Palomba	Palomba	NNP
cord-001835-0s7ok4uw	4380	18	1,2	1,2	CD
cord-001835-0s7ok4uw	4380	19	,	,	,
cord-001835-0s7ok4uw	4380	20	Roberto	Roberto	NNP
cord-001835-0s7ok4uw	4380	21	Molinaro	Molinaro	NNP
cord-001835-0s7ok4uw	4380	22	1	1	CD
cord-001835-0s7ok4uw	4380	23	,	,	,
cord-001835-0s7ok4uw	4380	24	Michael	Michael	NNP
cord-001835-0s7ok4uw	4380	25	Evangelopoulos	Evangelopoulos	NNP
cord-001835-0s7ok4uw	4380	26	1	1	CD
cord-001835-0s7ok4uw	4380	27	,	,	,
cord-001835-0s7ok4uw	4380	28	Francesco	Francesco	NNP
cord-001835-0s7ok4uw	4380	29	Salvatore	Salvatore	NNP
cord-001835-0s7ok4uw	4380	30	2,3	2,3	CD
cord-001835-0s7ok4uw	4380	31	,	,	,
cord-001835-0s7ok4uw	4380	32	Ennio	Ennio	NNP
cord-001835-0s7ok4uw	4380	33	Tasciotti	Tasciotti	NNP
cord-001835-0s7ok4uw	4380	34	1	1	CD
cord-001835-0s7ok4uw	4380	35	  	  	_SP
cord-001835-0s7ok4uw	4380	36	1	1	CD
cord-001835-0s7ok4uw	4381	1	The	the	DT
cord-001835-0s7ok4uw	4381	2	Houston	Houston	NNP
cord-001835-0s7ok4uw	4381	3	Methodist	Methodist	NNP
cord-001835-0s7ok4uw	4381	4	Research	Research	NNP
cord-001835-0s7ok4uw	4381	5	Institute	Institute	NNP
cord-001835-0s7ok4uw	4381	6	,	,	,
cord-001835-0s7ok4uw	4381	7	2	2	CD
cord-001835-0s7ok4uw	4381	8	Fondazione	Fondazione	NNP
cord-001835-0s7ok4uw	4381	9	IRCCS	IRCCS	NNP
cord-001835-0s7ok4uw	4381	10	SDN	SDN	NNP
cord-001835-0s7ok4uw	4381	11	,	,	,
cord-001835-0s7ok4uw	4381	12	3	3	CD
cord-001835-0s7ok4uw	4381	13	 	 	_SP
cord-001835-0s7ok4uw	4381	14	Nanomedicine	Nanomedicine	NNP
cord-001835-0s7ok4uw	4381	15	aims	aim	VBZ
cord-001835-0s7ok4uw	4381	16	to	to	TO
cord-001835-0s7ok4uw	4381	17	improve	improve	VB
cord-001835-0s7ok4uw	4381	18	drug	drug	NN
cord-001835-0s7ok4uw	4381	19	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4381	20	by	by	IN
cord-001835-0s7ok4uw	4381	21	enhancing	enhance	VBG
cord-001835-0s7ok4uw	4381	22	targeting	targeting	NN
cord-001835-0s7ok4uw	4381	23	and	and	CC
cord-001835-0s7ok4uw	4381	24	biocompatibility	biocompatibility	NN
cord-001835-0s7ok4uw	4381	25	,	,	,
cord-001835-0s7ok4uw	4381	26	and	and	CC
cord-001835-0s7ok4uw	4381	27	reducing	reduce	VBG
cord-001835-0s7ok4uw	4381	28	side	side	NN
cord-001835-0s7ok4uw	4381	29	effects	effect	NNS
cord-001835-0s7ok4uw	4381	30	.	.	.
cord-001835-0s7ok4uw	4382	1	Multiple	multiple	JJ
cord-001835-0s7ok4uw	4382	2	surface	surface	NN
cord-001835-0s7ok4uw	4382	3	modifications	modification	NNS
cord-001835-0s7ok4uw	4382	4	have	have	VBP
cord-001835-0s7ok4uw	4382	5	been	be	VBN
cord-001835-0s7ok4uw	4382	6	proposed	propose	VBN
cord-001835-0s7ok4uw	4382	7	to	to	TO
cord-001835-0s7ok4uw	4382	8	provide	provide	VB
cord-001835-0s7ok4uw	4382	9	nanocarriers	nanocarrier	NNS
cord-001835-0s7ok4uw	4382	10	with	with	IN
cord-001835-0s7ok4uw	4382	11	these	these	DT
cord-001835-0s7ok4uw	4382	12	features	feature	NNS
cord-001835-0s7ok4uw	4382	13	,	,	,
cord-001835-0s7ok4uw	4382	14	based	base	VBN
cord-001835-0s7ok4uw	4382	15	on	on	IN
cord-001835-0s7ok4uw	4382	16	complex	complex	JJ
cord-001835-0s7ok4uw	4382	17	synthesis	synthesis	NN
cord-001835-0s7ok4uw	4382	18	processes	process	NNS
cord-001835-0s7ok4uw	4382	19	and	and	CC
cord-001835-0s7ok4uw	4382	20	very	very	RB
cord-001835-0s7ok4uw	4382	21	often	often	RB
cord-001835-0s7ok4uw	4382	22	inefficient	inefficient	JJ
cord-001835-0s7ok4uw	4382	23	in	in	IN
cord-001835-0s7ok4uw	4382	24	contemporary	contemporary	JJ
cord-001835-0s7ok4uw	4382	25	providing	provide	VBG
cord-001835-0s7ok4uw	4382	26	biological	biological	JJ
cord-001835-0s7ok4uw	4382	27	tolerance	tolerance	NN
cord-001835-0s7ok4uw	4382	28	and	and	CC
cord-001835-0s7ok4uw	4382	29	targeting	target	VBG
cord-001835-0s7ok4uw	4382	30	properties	property	NNS
cord-001835-0s7ok4uw	4382	31	[	[	-LRB-
cord-001835-0s7ok4uw	4382	32	1	1	CD
cord-001835-0s7ok4uw	4382	33	]	]	-RRB-
cord-001835-0s7ok4uw	4382	34	.	.	.
cord-001835-0s7ok4uw	4383	1	Bio	Bio	NNP
cord-001835-0s7ok4uw	4383	2	-	-	HYPH
cord-001835-0s7ok4uw	4383	3	inspired	inspire	VBN
cord-001835-0s7ok4uw	4383	4	approaches	approach	NNS
cord-001835-0s7ok4uw	4383	5	based	base	VBN
cord-001835-0s7ok4uw	4383	6	on	on	IN
cord-001835-0s7ok4uw	4383	7	surface	surface	NN
cord-001835-0s7ok4uw	4383	8	coatings	coating	NNS
cord-001835-0s7ok4uw	4383	9	developed	develop	VBN
cord-001835-0s7ok4uw	4383	10	from	from	IN
cord-001835-0s7ok4uw	4383	11	the	the	DT
cord-001835-0s7ok4uw	4383	12	purified	purify	VBN
cord-001835-0s7ok4uw	4383	13	cell	cell	NN
cord-001835-0s7ok4uw	4383	14	membrane	membrane	NN
cord-001835-0s7ok4uw	4383	15	of	of	IN
cord-001835-0s7ok4uw	4383	16	immune	immune	JJ
cord-001835-0s7ok4uw	4383	17	cells	cell	NNS
cord-001835-0s7ok4uw	4383	18	represents	represent	VBZ
cord-001835-0s7ok4uw	4383	19	a	a	DT
cord-001835-0s7ok4uw	4383	20	new	new	JJ
cord-001835-0s7ok4uw	4383	21	paradigm	paradigm	NN
cord-001835-0s7ok4uw	4383	22	shift	shift	NN
cord-001835-0s7ok4uw	4383	23	for	for	IN
cord-001835-0s7ok4uw	4383	24	the	the	DT
cord-001835-0s7ok4uw	4383	25	development	development	NN
cord-001835-0s7ok4uw	4383	26	of	of	IN
cord-001835-0s7ok4uw	4383	27	carrier	carrier	NN
cord-001835-0s7ok4uw	4383	28	enable	enable	VBP
cord-001835-0s7ok4uw	4383	29	of	of	IN
cord-001835-0s7ok4uw	4383	30	prolong	prolong	JJ
cord-001835-0s7ok4uw	4383	31	circulation	circulation	NN
cord-001835-0s7ok4uw	4383	32	and	and	CC
cord-001835-0s7ok4uw	4383	33	proper	proper	JJ
cord-001835-0s7ok4uw	4383	34	tumoritropic	tumoritropic	NNP
cord-001835-0s7ok4uw	4383	35	capabilities	capability	NNS
cord-001835-0s7ok4uw	4383	36	.	.	.
cord-001835-0s7ok4uw	4384	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4384	2	showed	show	VBD
cord-001835-0s7ok4uw	4384	3	that	that	IN
cord-001835-0s7ok4uw	4384	4	nanoporous	nanoporous	NNP
cord-001835-0s7ok4uw	4384	5	silicon	silicon	NNP
cord-001835-0s7ok4uw	4384	6	(	(	-LRB-
cord-001835-0s7ok4uw	4384	7	NPS	NPS	NNP
cord-001835-0s7ok4uw	4384	8	)	)	-RRB-
cord-001835-0s7ok4uw	4384	9	particles	particle	NNS
cord-001835-0s7ok4uw	4384	10	coated	coat	VBN
cord-001835-0s7ok4uw	4384	11	with	with	IN
cord-001835-0s7ok4uw	4384	12	leukocyte	leukocyte	NN
cord-001835-0s7ok4uw	4384	13	cellular	cellular	JJ
cord-001835-0s7ok4uw	4384	14	membranes	membrane	NNS
cord-001835-0s7ok4uw	4384	15	-Leukolike	-leukolike	IN
cord-001835-0s7ok4uw	4384	16	Vectors	Vectors	NNP
cord-001835-0s7ok4uw	4384	17	(	(	-LRB-
cord-001835-0s7ok4uw	4384	18	LLVs	LLVs	NNP
cord-001835-0s7ok4uw	4384	19	)	)	-RRB-
cord-001835-0s7ok4uw	4384	20	-possess	-possess	:
cord-001835-0s7ok4uw	4384	21	cell	cell	NN
cord-001835-0s7ok4uw	4384	22	-	-	HYPH
cord-001835-0s7ok4uw	4384	23	like	like	JJ
cord-001835-0s7ok4uw	4384	24	properties	property	NNS
cord-001835-0s7ok4uw	4384	25	[	[	-LRB-
cord-001835-0s7ok4uw	4384	26	2	2	CD
cord-001835-0s7ok4uw	4384	27	]	]	-RRB-
cord-001835-0s7ok4uw	4384	28	.	.	.
cord-001835-0s7ok4uw	4385	1	LLVs	LLVs	NNP
cord-001835-0s7ok4uw	4385	2	can	can	MD
cord-001835-0s7ok4uw	4385	3	escape	escape	VB
cord-001835-0s7ok4uw	4385	4	macrophage	macrophage	NN
cord-001835-0s7ok4uw	4385	5	uptake	uptake	NN
cord-001835-0s7ok4uw	4385	6	,	,	,
cord-001835-0s7ok4uw	4385	7	delay	delay	NN
cord-001835-0s7ok4uw	4385	8	sequestration	sequestration	NN
cord-001835-0s7ok4uw	4385	9	by	by	IN
cord-001835-0s7ok4uw	4385	10	the	the	DT
cord-001835-0s7ok4uw	4385	11	reticulo	reticulo	NN
cord-001835-0s7ok4uw	4385	12	-	-	HYPH
cord-001835-0s7ok4uw	4385	13	endothelial	endothelial	JJ
cord-001835-0s7ok4uw	4385	14	system	system	NN
cord-001835-0s7ok4uw	4385	15	,	,	,
cord-001835-0s7ok4uw	4385	16	target	target	NN
cord-001835-0s7ok4uw	4385	17	tumor	tumor	NN
cord-001835-0s7ok4uw	4386	1	inflamed	inflamed	JJ
cord-001835-0s7ok4uw	4386	2	vasculature	vasculature	NN
cord-001835-0s7ok4uw	4386	3	and	and	CC
cord-001835-0s7ok4uw	4386	4	accumulate	accumulate	VBP
cord-001835-0s7ok4uw	4386	5	within	within	IN
cord-001835-0s7ok4uw	4386	6	the	the	DT
cord-001835-0s7ok4uw	4386	7	cancer	cancer	NN
cord-001835-0s7ok4uw	4386	8	parenchyma	parenchyma	NN
cord-001835-0s7ok4uw	4386	9	[	[	-LRB-
cord-001835-0s7ok4uw	4386	10	2	2	CD
cord-001835-0s7ok4uw	4386	11	]	]	-RRB-
cord-001835-0s7ok4uw	4386	12	.	.	.
cord-001835-0s7ok4uw	4387	1	LLVs	LLVs	NNP
cord-001835-0s7ok4uw	4387	2	were	be	VBD
cord-001835-0s7ok4uw	4387	3	fully	fully	RB
cord-001835-0s7ok4uw	4387	4	characterized	characterize	VBN
cord-001835-0s7ok4uw	4387	5	for	for	IN
cord-001835-0s7ok4uw	4387	6	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4387	7	shape	shape	NN
cord-001835-0s7ok4uw	4387	8	,	,	,
cord-001835-0s7ok4uw	4387	9	size	size	NN
cord-001835-0s7ok4uw	4387	10	,	,	,
cord-001835-0s7ok4uw	4387	11	surface	surface	NN
cord-001835-0s7ok4uw	4387	12	charge	charge	NN
cord-001835-0s7ok4uw	4387	13	and	and	CC
cord-001835-0s7ok4uw	4387	14	coating	coating	NN
cord-001835-0s7ok4uw	4387	15	through	through	IN
cord-001835-0s7ok4uw	4387	16	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	4387	17	light	light	JJ
cord-001835-0s7ok4uw	4387	18	scattering	scattering	NN
cord-001835-0s7ok4uw	4387	19	and	and	CC
cord-001835-0s7ok4uw	4387	20	scanning	scan	VBG
cord-001835-0s7ok4uw	4387	21	electron	electron	NN
cord-001835-0s7ok4uw	4387	22	microscopy	microscopy	NN
cord-001835-0s7ok4uw	4387	23	.	.	.
cord-001835-0s7ok4uw	4388	1	In	in	IN
cord-001835-0s7ok4uw	4388	2	addition	addition	NN
cord-001835-0s7ok4uw	4388	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4388	4	characterized	characterize	VBD
cord-001835-0s7ok4uw	4388	5	the	the	DT
cord-001835-0s7ok4uw	4388	6	content	content	NN
cord-001835-0s7ok4uw	4388	7	and	and	CC
cord-001835-0s7ok4uw	4388	8	function	function	NN
cord-001835-0s7ok4uw	4388	9	of	of	IN
cord-001835-0s7ok4uw	4388	10	the	the	DT
cord-001835-0s7ok4uw	4388	11	leukocyte	leukocyte	NN
cord-001835-0s7ok4uw	4388	12	's	's	POS
cord-001835-0s7ok4uw	4388	13	proteins	protein	NNS
cord-001835-0s7ok4uw	4388	14	transferred	transfer	VBN
cord-001835-0s7ok4uw	4388	15	onto	onto	IN
cord-001835-0s7ok4uw	4388	16	the	the	DT
cord-001835-0s7ok4uw	4388	17	LLVs	llv	NNS
cord-001835-0s7ok4uw	4388	18	coating	coat	VBG
cord-001835-0s7ok4uw	4388	19	through	through	IN
cord-001835-0s7ok4uw	4388	20	high	high	JJ
cord-001835-0s7ok4uw	4388	21	-	-	HYPH
cord-001835-0s7ok4uw	4388	22	throughput	throughput	NN
cord-001835-0s7ok4uw	4388	23	proteomic	proteomic	JJ
cord-001835-0s7ok4uw	4388	24	analysis	analysis	NN
cord-001835-0s7ok4uw	4388	25	and	and	CC
cord-001835-0s7ok4uw	4388	26	the	the	DT
cord-001835-0s7ok4uw	4388	27	results	result	NNS
cord-001835-0s7ok4uw	4388	28	revealed	reveal	VBD
cord-001835-0s7ok4uw	4388	29	the	the	DT
cord-001835-0s7ok4uw	4388	30	presence	presence	NN
cord-001835-0s7ok4uw	4388	31	and	and	CC
cord-001835-0s7ok4uw	4388	32	the	the	DT
cord-001835-0s7ok4uw	4388	33	correct	correct	JJ
cord-001835-0s7ok4uw	4388	34	orientation	orientation	NN
cord-001835-0s7ok4uw	4388	35	of	of	IN
cord-001835-0s7ok4uw	4388	36	several	several	JJ
cord-001835-0s7ok4uw	4388	37	important	important	JJ
cord-001835-0s7ok4uw	4388	38	markers	marker	NNS
cord-001835-0s7ok4uw	4388	39	of	of	IN
cord-001835-0s7ok4uw	4388	40	leukocytes	leukocyte	NNS
cord-001835-0s7ok4uw	4388	41	:	:	:
cord-001835-0s7ok4uw	4388	42	CD45	CD45	NNP
cord-001835-0s7ok4uw	4388	43	,	,	,
cord-001835-0s7ok4uw	4388	44	CD47	CD47	NNP
cord-001835-0s7ok4uw	4388	45	and	and	CC
cord-001835-0s7ok4uw	4388	46	MHC	MHC	NNP
cord-001835-0s7ok4uw	4388	47	-	-	:
cord-001835-0s7ok4uw	4388	48	I	-PRON-	PRP
cord-001835-0s7ok4uw	4388	49	were	be	VBD
cord-001835-0s7ok4uw	4388	50	identified	identify	VBN
cord-001835-0s7ok4uw	4388	51	as	as	IN
cord-001835-0s7ok4uw	4388	52	key	key	JJ
cord-001835-0s7ok4uw	4388	53	players	player	NNS
cord-001835-0s7ok4uw	4388	54	in	in	IN
cord-001835-0s7ok4uw	4388	55	determining	determine	VBG
cord-001835-0s7ok4uw	4388	56	LLVs	llv	NNS
cord-001835-0s7ok4uw	4388	57	biocompatibility	biocompatibility	NN
cord-001835-0s7ok4uw	4388	58	,	,	,
cord-001835-0s7ok4uw	4388	59	while	while	IN
cord-001835-0s7ok4uw	4388	60	Leukocyte	Leukocyte	NNP
cord-001835-0s7ok4uw	4388	61	Associated	Associated	NNP
cord-001835-0s7ok4uw	4388	62	Function-1	Function-1	NNP
cord-001835-0s7ok4uw	4388	63	(	(	-LRB-
cord-001835-0s7ok4uw	4388	64	LFA-1	LFA-1	NNP
cord-001835-0s7ok4uw	4388	65	)	)	-RRB-
cord-001835-0s7ok4uw	4388	66	and	and	CC
cord-001835-0s7ok4uw	4388	67	Mac-1	Mac-1	NNP
cord-001835-0s7ok4uw	4388	68	contributed	contribute	VBD
cord-001835-0s7ok4uw	4388	69	to	to	IN
cord-001835-0s7ok4uw	4388	70	the	the	DT
cord-001835-0s7ok4uw	4388	71	LLVs	llv	NNS
cord-001835-0s7ok4uw	4388	72	targeting	target	VBG
cord-001835-0s7ok4uw	4388	73	ability	ability	NN
cord-001835-0s7ok4uw	4388	74	and	and	CC
cord-001835-0s7ok4uw	4388	75	bioactivity	bioactivity	NN
cord-001835-0s7ok4uw	4388	76	towards	towards	IN
cord-001835-0s7ok4uw	4388	77	inflamed	inflamed	JJ
cord-001835-0s7ok4uw	4388	78	endothelium	endothelium	NN
cord-001835-0s7ok4uw	4388	79	[	[	-LRB-
cord-001835-0s7ok4uw	4388	80	3	3	CD
cord-001835-0s7ok4uw	4388	81	]	]	-RRB-
cord-001835-0s7ok4uw	4388	82	.	.	.
cord-001835-0s7ok4uw	4389	1	Recent	recent	JJ
cord-001835-0s7ok4uw	4389	2	investigation	investigation	NN
cord-001835-0s7ok4uw	4389	3	showed	show	VBD
cord-001835-0s7ok4uw	4389	4	that	that	IN
cord-001835-0s7ok4uw	4389	5	the	the	DT
cord-001835-0s7ok4uw	4389	6	coating	coating	NN
cord-001835-0s7ok4uw	4389	7	induced	induce	VBD
cord-001835-0s7ok4uw	4389	8	the	the	DT
cord-001835-0s7ok4uw	4389	9	formation	formation	NN
cord-001835-0s7ok4uw	4389	10	of	of	IN
cord-001835-0s7ok4uw	4389	11	a	a	DT
cord-001835-0s7ok4uw	4389	12	singular	singular	JJ
cord-001835-0s7ok4uw	4389	13	protein	protein	NN
cord-001835-0s7ok4uw	4389	14	corona	corona	NN
cord-001835-0s7ok4uw	4389	15	(	(	-LRB-
cord-001835-0s7ok4uw	4389	16	i.e.	i.e.	FW
cord-001835-0s7ok4uw	4389	17	the	the	DT
cord-001835-0s7ok4uw	4389	18	protein	protein	NN
cord-001835-0s7ok4uw	4389	19	adsorption	adsorption	NN
cord-001835-0s7ok4uw	4389	20	layer	layer	NN
cord-001835-0s7ok4uw	4389	21	)	)	-RRB-
cord-001835-0s7ok4uw	4389	22	on	on	IN
cord-001835-0s7ok4uw	4389	23	the	the	DT
cord-001835-0s7ok4uw	4389	24	surface	surface	NN
cord-001835-0s7ok4uw	4389	25	of	of	IN
cord-001835-0s7ok4uw	4389	26	the	the	DT
cord-001835-0s7ok4uw	4389	27	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	4389	28	compared	compare	VBN
cord-001835-0s7ok4uw	4389	29	to	to	IN
cord-001835-0s7ok4uw	4389	30	negative	negative	JJ
cord-001835-0s7ok4uw	4389	31	control	control	NN
cord-001835-0s7ok4uw	4389	32	following	follow	VBG
cord-001835-0s7ok4uw	4389	33	in	in	IN
cord-001835-0s7ok4uw	4389	34	vivo	vivo	NN
cord-001835-0s7ok4uw	4389	35	injection	injection	NN
cord-001835-0s7ok4uw	4389	36	.	.	.
cord-001835-0s7ok4uw	4390	1	In	in	IN
cord-001835-0s7ok4uw	4390	2	addition	addition	NN
cord-001835-0s7ok4uw	4390	3	,	,	,
cord-001835-0s7ok4uw	4390	4	the	the	DT
cord-001835-0s7ok4uw	4390	5	proteolipid	proteolipid	NN
cord-001835-0s7ok4uw	4390	6	coating	coating	NN
cord-001835-0s7ok4uw	4390	7	favored	favor	VBD
cord-001835-0s7ok4uw	4390	8	active	active	JJ
cord-001835-0s7ok4uw	4390	9	extravasation	extravasation	NN
cord-001835-0s7ok4uw	4390	10	of	of	IN
cord-001835-0s7ok4uw	4390	11	the	the	DT
cord-001835-0s7ok4uw	4390	12	LLVs	llv	NNS
cord-001835-0s7ok4uw	4390	13	in	in	IN
cord-001835-0s7ok4uw	4390	14	the	the	DT
cord-001835-0s7ok4uw	4390	15	tumor	tumor	NN
cord-001835-0s7ok4uw	4390	16	vasculature	vasculature	NN
cord-001835-0s7ok4uw	4390	17	by	by	IN
cord-001835-0s7ok4uw	4390	18	molecular	molecular	JJ
cord-001835-0s7ok4uw	4390	19	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4390	20	similar	similar	JJ
cord-001835-0s7ok4uw	4390	21	to	to	IN
cord-001835-0s7ok4uw	4390	22	those	those	DT
cord-001835-0s7ok4uw	4390	23	used	use	VBN
cord-001835-0s7ok4uw	4390	24	by	by	IN
cord-001835-0s7ok4uw	4390	25	tumor	tumor	NN
cord-001835-0s7ok4uw	4390	26	infiltrating	infiltrate	VBG
cord-001835-0s7ok4uw	4390	27	leukocytes	leukocyte	NNS
cord-001835-0s7ok4uw	4390	28	.	.	.
cord-001835-0s7ok4uw	4391	1	This	this	DT
cord-001835-0s7ok4uw	4391	2	work	work	NN
cord-001835-0s7ok4uw	4391	3	shows	show	VBZ
cord-001835-0s7ok4uw	4391	4	that	that	DT
cord-001835-0s7ok4uw	4391	5	is	be	VBZ
cord-001835-0s7ok4uw	4391	6	possible	possible	JJ
cord-001835-0s7ok4uw	4391	7	to	to	TO
cord-001835-0s7ok4uw	4391	8	transfer	transfer	VB
cord-001835-0s7ok4uw	4391	9	biologically	biologically	RB
cord-001835-0s7ok4uw	4391	10	active	active	JJ
cord-001835-0s7ok4uw	4391	11	leukocyte	leukocyte	NN
cord-001835-0s7ok4uw	4391	12	membrane	membrane	NN
cord-001835-0s7ok4uw	4391	13	proteins	protein	NNS
cord-001835-0s7ok4uw	4391	14	onto	onto	IN
cord-001835-0s7ok4uw	4391	15	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	4391	16	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	4391	17	,	,	,
cord-001835-0s7ok4uw	4391	18	thus	thus	RB
cord-001835-0s7ok4uw	4391	19	creating	create	VBG
cord-001835-0s7ok4uw	4391	20	biomimetic	biomimetic	JJ
cord-001835-0s7ok4uw	4391	21	carriers	carrier	NNS
cord-001835-0s7ok4uw	4391	22	retaining	retain	VBG
cord-001835-0s7ok4uw	4391	23	cell	cell	NN
cord-001835-0s7ok4uw	4391	24	-	-	HYPH
cord-001835-0s7ok4uw	4391	25	like	like	JJ
cord-001835-0s7ok4uw	4391	26	functions	function	NNS
cord-001835-0s7ok4uw	4391	27	that	that	WDT
cord-001835-0s7ok4uw	4391	28	are	be	VBP
cord-001835-0s7ok4uw	4391	29	not	not	RB
cord-001835-0s7ok4uw	4391	30	affected	affect	VBN
cord-001835-0s7ok4uw	4391	31	by	by	IN
cord-001835-0s7ok4uw	4391	32	the	the	DT
cord-001835-0s7ok4uw	4391	33	protein	protein	NN
cord-001835-0s7ok4uw	4391	34	corona	corona	NN
cord-001835-0s7ok4uw	4391	35	effect	effect	NN
cord-001835-0s7ok4uw	4391	36	that	that	WDT
cord-001835-0s7ok4uw	4391	37	occurs	occur	VBZ
cord-001835-0s7ok4uw	4391	38	in	in	IN
cord-001835-0s7ok4uw	4391	39	vivo	vivo	NN
cord-001835-0s7ok4uw	4391	40	.	.	.
cord-001835-0s7ok4uw	4392	1	The	the	DT
cord-001835-0s7ok4uw	4392	2	targeting	targeting	NN
cord-001835-0s7ok4uw	4392	3	of	of	IN
cord-001835-0s7ok4uw	4392	4	the	the	DT
cord-001835-0s7ok4uw	4392	5	inflamed	inflamed	JJ
cord-001835-0s7ok4uw	4392	6	endothelium	endothelium	NN
cord-001835-0s7ok4uw	4392	7	can	can	MD
cord-001835-0s7ok4uw	4392	8	be	be	VB
cord-001835-0s7ok4uw	4392	9	applied	apply	VBN
cord-001835-0s7ok4uw	4392	10	to	to	IN
cord-001835-0s7ok4uw	4392	11	a	a	DT
cord-001835-0s7ok4uw	4392	12	broad	broad	JJ
cord-001835-0s7ok4uw	4392	13	range	range	NN
cord-001835-0s7ok4uw	4392	14	of	of	IN
cord-001835-0s7ok4uw	4392	15	diseases	disease	NNS
cord-001835-0s7ok4uw	4392	16	and	and	CC
cord-001835-0s7ok4uw	4392	17	the	the	DT
cord-001835-0s7ok4uw	4392	18	approach	approach	NN
cord-001835-0s7ok4uw	4392	19	used	use	VBD
cord-001835-0s7ok4uw	4392	20	to	to	TO
cord-001835-0s7ok4uw	4392	21	formulate	formulate	VB
cord-001835-0s7ok4uw	4392	22	the	the	DT
cord-001835-0s7ok4uw	4392	23	system	system	NN
cord-001835-0s7ok4uw	4392	24	could	could	MD
cord-001835-0s7ok4uw	4392	25	open	open	VB
cord-001835-0s7ok4uw	4392	26	new	new	JJ
cord-001835-0s7ok4uw	4392	27	avenues	avenue	NNS
cord-001835-0s7ok4uw	4392	28	for	for	IN
cord-001835-0s7ok4uw	4392	29	the	the	DT
cord-001835-0s7ok4uw	4392	30	fabrication	fabrication	NN
cord-001835-0s7ok4uw	4392	31	of	of	IN
cord-001835-0s7ok4uw	4392	32	the	the	DT
cord-001835-0s7ok4uw	4392	33	next	next	JJ
cord-001835-0s7ok4uw	4392	34	generation	generation	NN
cord-001835-0s7ok4uw	4392	35	of	of	IN
cord-001835-0s7ok4uw	4392	36	personalized	personalized	JJ
cord-001835-0s7ok4uw	4392	37	treatments	treatment	NNS
cord-001835-0s7ok4uw	4392	38	by	by	IN
cord-001835-0s7ok4uw	4392	39	using	use	VBG
cord-001835-0s7ok4uw	4392	40	as	as	IN
cord-001835-0s7ok4uw	4392	41	cell	cell	NN
cord-001835-0s7ok4uw	4392	42	membrane	membrane	NN
cord-001835-0s7ok4uw	4392	43	source	source	NN
cord-001835-0s7ok4uw	4392	44	the	the	DT
cord-001835-0s7ok4uw	4392	45	immune	immune	JJ
cord-001835-0s7ok4uw	4392	46	cells	cell	NNS
cord-001835-0s7ok4uw	4392	47	of	of	IN
cord-001835-0s7ok4uw	4392	48	patients	patient	NNS
cord-001835-0s7ok4uw	4392	49	.	.	.
cord-001835-0s7ok4uw	4393	1	References	reference	NNS
cord-001835-0s7ok4uw	4393	2	:	:	:
cord-001835-0s7ok4uw	4393	3	[	[	-LRB-
cord-001835-0s7ok4uw	4393	4	1	1	CD
cord-001835-0s7ok4uw	4393	5	]	]	-RRB-
cord-001835-0s7ok4uw	4393	6	Alessandro	Alessandro	NNP
cord-001835-0s7ok4uw	4393	7	Parodi	Parodi	NNP
cord-001835-0s7ok4uw	4393	8	,	,	,
cord-001835-0s7ok4uw	4393	9	Claudia	Claudia	NNP
cord-001835-0s7ok4uw	4393	10	Corbo	Corbo	NNP
cord-001835-0s7ok4uw	4393	11	,	,	,
cord-001835-0s7ok4uw	4393	12	Armando	Armando	NNP
cord-001835-0s7ok4uw	4393	13	Cevenini	Cevenini	NNP
cord-001835-0s7ok4uw	4393	14	,	,	,
cord-001835-0s7ok4uw	4393	15	Roberto	Roberto	NNP
cord-001835-0s7ok4uw	4393	16	Molinaro	Molinaro	NNP
cord-001835-0s7ok4uw	4393	17	,	,	,
cord-001835-0s7ok4uw	4393	18	Roberto	Roberto	NNP
cord-001835-0s7ok4uw	4393	19	Palomba	Palomba	NNP
cord-001835-0s7ok4uw	4393	20	,	,	,
cord-001835-0s7ok4uw	4393	21	Laura	Laura	NNP
cord-001835-0s7ok4uw	4393	22	Pandolfi	Pandolfi	NNP
cord-001835-0s7ok4uw	4393	23	,	,	,
cord-001835-0s7ok4uw	4393	24	Marco	Marco	NNP
cord-001835-0s7ok4uw	4393	25	Agostini	Agostini	NNP
cord-001835-0s7ok4uw	4393	26	,	,	,
cord-001835-0s7ok4uw	4393	27	Francesco	Francesco	NNP
cord-001835-0s7ok4uw	4393	28	Salvatore	Salvatore	NNP
cord-001835-0s7ok4uw	4393	29	,	,	,
cord-001835-0s7ok4uw	4393	30	Ennio	Ennio	NNP
cord-001835-0s7ok4uw	4393	31	Tasciotti	Tasciotti	NNP
cord-001835-0s7ok4uw	4393	32	.	.	.
cord-001835-0s7ok4uw	4394	1	Enabling	enable	VBG
cord-001835-0s7ok4uw	4394	2	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	4394	3	delivery	delivery	NN
cord-001835-0s7ok4uw	4394	4	and	and	CC
cord-001835-0s7ok4uw	4394	5	organelle	organelle	NN
cord-001835-0s7ok4uw	4394	6	targeting	target	VBG
cord-001835-0s7ok4uw	4394	7	by	by	IN
cord-001835-0s7ok4uw	4394	8	surface	surface	NN
cord-001835-0s7ok4uw	4394	9	modification	modification	NN
cord-001835-0s7ok4uw	4394	10	of	of	IN
cord-001835-0s7ok4uw	4394	11	nanocarriers	nanocarrier	NNS
cord-001835-0s7ok4uw	4394	12	.	.	.
cord-001835-0s7ok4uw	4395	1	Nanomedicine	Nanomedicine	NNP
cord-001835-0s7ok4uw	4395	2	UK	UK	NNP
cord-001835-0s7ok4uw	4395	3	.	.	.
cord-001835-0s7ok4uw	4396	1	Accepted	accept	VBN
cord-001835-0s7ok4uw	4396	2	.	.	.
cord-001835-0s7ok4uw	4397	1	Steroid	steroid	JJ
cord-001835-0s7ok4uw	4397	2	hormone	hormone	NN
cord-001835-0s7ok4uw	4397	3	receptors	receptor	NNS
cord-001835-0s7ok4uw	4397	4	are	be	VBP
cord-001835-0s7ok4uw	4397	5	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	4397	6	receptors	receptor	NNS
cord-001835-0s7ok4uw	4397	7	that	that	WDT
cord-001835-0s7ok4uw	4397	8	initiate	initiate	VBP
cord-001835-0s7ok4uw	4397	9	signal	signal	NN
cord-001835-0s7ok4uw	4397	10	transduction	transduction	NN
cord-001835-0s7ok4uw	4397	11	in	in	IN
cord-001835-0s7ok4uw	4397	12	response	response	NN
cord-001835-0s7ok4uw	4397	13	to	to	IN
cord-001835-0s7ok4uw	4397	14	steroid	steroid	NN
cord-001835-0s7ok4uw	4397	15	hormones	hormone	NNS
cord-001835-0s7ok4uw	4397	16	,	,	,
cord-001835-0s7ok4uw	4397	17	including	include	VBG
cord-001835-0s7ok4uw	4397	18	oestrogen	oestrogen	NN
cord-001835-0s7ok4uw	4397	19	and	and	CC
cord-001835-0s7ok4uw	4397	20	androgens	androgen	NNS
cord-001835-0s7ok4uw	4397	21	.	.	.
cord-001835-0s7ok4uw	4398	1	Generally	generally	RB
cord-001835-0s7ok4uw	4398	2	,	,	,
cord-001835-0s7ok4uw	4398	3	the	the	DT
cord-001835-0s7ok4uw	4398	4	binding	binding	NN
cord-001835-0s7ok4uw	4398	5	of	of	IN
cord-001835-0s7ok4uw	4398	6	the	the	DT
cord-001835-0s7ok4uw	4398	7	steroid	steroid	NN
cord-001835-0s7ok4uw	4398	8	to	to	IN
cord-001835-0s7ok4uw	4398	9	the	the	DT
cord-001835-0s7ok4uw	4398	10	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	4398	11	receptor	receptor	NN
cord-001835-0s7ok4uw	4398	12	induces	induce	VBZ
cord-001835-0s7ok4uw	4398	13	the	the	DT
cord-001835-0s7ok4uw	4398	14	protein	protein	NN
cord-001835-0s7ok4uw	4398	15	to	to	TO
cord-001835-0s7ok4uw	4398	16	form	form	VB
cord-001835-0s7ok4uw	4398	17	a	a	DT
cord-001835-0s7ok4uw	4398	18	dimer	dimer	NN
cord-001835-0s7ok4uw	4398	19	and	and	CC
cord-001835-0s7ok4uw	4398	20	relocate	relocate	VB
cord-001835-0s7ok4uw	4398	21	onto	onto	IN
cord-001835-0s7ok4uw	4398	22	the	the	DT
cord-001835-0s7ok4uw	4398	23	chromatin	chromatin	NN
cord-001835-0s7ok4uw	4398	24	,	,	,
cord-001835-0s7ok4uw	4398	25	although	although	IN
cord-001835-0s7ok4uw	4398	26	the	the	DT
cord-001835-0s7ok4uw	4398	27	order	order	NN
cord-001835-0s7ok4uw	4398	28	of	of	IN
cord-001835-0s7ok4uw	4398	29	these	these	DT
cord-001835-0s7ok4uw	4398	30	events	event	NNS
cord-001835-0s7ok4uw	4398	31	may	may	MD
cord-001835-0s7ok4uw	4398	32	vary	vary	VB
cord-001835-0s7ok4uw	4398	33	.	.	.
cord-001835-0s7ok4uw	4399	1	The	the	DT
cord-001835-0s7ok4uw	4399	2	location	location	NN
cord-001835-0s7ok4uw	4399	3	of	of	IN
cord-001835-0s7ok4uw	4399	4	receptor	receptor	NN
cord-001835-0s7ok4uw	4399	5	binding	bind	VBG
cord-001835-0s7ok4uw	4399	6	on	on	IN
cord-001835-0s7ok4uw	4399	7	the	the	DT
cord-001835-0s7ok4uw	4399	8	chromatin	chromatin	NN
cord-001835-0s7ok4uw	4399	9	is	be	VBZ
cord-001835-0s7ok4uw	4399	10	defined	define	VBN
cord-001835-0s7ok4uw	4399	11	by	by	IN
cord-001835-0s7ok4uw	4399	12	specific	specific	JJ
cord-001835-0s7ok4uw	4399	13	hormone	hormone	NN
cord-001835-0s7ok4uw	4399	14	response	response	NN
cord-001835-0s7ok4uw	4399	15	elements	element	NNS
cord-001835-0s7ok4uw	4399	16	(	(	-LRB-
cord-001835-0s7ok4uw	4399	17	HRE	HRE	NNP
cord-001835-0s7ok4uw	4399	18	)	)	-RRB-
cord-001835-0s7ok4uw	4399	19	.	.	.
cord-001835-0s7ok4uw	4400	1	Once	once	RB
cord-001835-0s7ok4uw	4400	2	located	locate	VBN
cord-001835-0s7ok4uw	4400	3	,	,	,
cord-001835-0s7ok4uw	4400	4	the	the	DT
cord-001835-0s7ok4uw	4400	5	receptor	receptor	NN
cord-001835-0s7ok4uw	4400	6	promotes	promote	VBZ
cord-001835-0s7ok4uw	4400	7	gene	gene	NN
cord-001835-0s7ok4uw	4400	8	activation	activation	NN
cord-001835-0s7ok4uw	4400	9	by	by	IN
cord-001835-0s7ok4uw	4400	10	the	the	DT
cord-001835-0s7ok4uw	4400	11	recruitment	recruitment	NN
cord-001835-0s7ok4uw	4400	12	of	of	IN
cord-001835-0s7ok4uw	4400	13	other	other	JJ
cord-001835-0s7ok4uw	4400	14	co	co	NNS
cord-001835-0s7ok4uw	4400	15	-	-	NNS
cord-001835-0s7ok4uw	4400	16	factors	factor	NNS
cord-001835-0s7ok4uw	4400	17	.	.	.
cord-001835-0s7ok4uw	4401	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4401	2	is	be	VBZ
cord-001835-0s7ok4uw	4401	3	this	this	DT
cord-001835-0s7ok4uw	4401	4	process	process	NN
cord-001835-0s7ok4uw	4401	5	that	that	WDT
cord-001835-0s7ok4uw	4401	6	makes	make	VBZ
cord-001835-0s7ok4uw	4401	7	the	the	DT
cord-001835-0s7ok4uw	4401	8	complex	complex	NN
cord-001835-0s7ok4uw	4401	9	of	of	IN
cord-001835-0s7ok4uw	4401	10	receptor	receptor	NN
cord-001835-0s7ok4uw	4401	11	protein	protein	NN
cord-001835-0s7ok4uw	4401	12	and	and	CC
cord-001835-0s7ok4uw	4401	13	co	co	NNS
cord-001835-0s7ok4uw	4401	14	-	-	NNS
cord-001835-0s7ok4uw	4401	15	factors	factor	NNS
cord-001835-0s7ok4uw	4401	16	play	play	VBP
cord-001835-0s7ok4uw	4401	17	a	a	DT
cord-001835-0s7ok4uw	4401	18	pivotal	pivotal	JJ
cord-001835-0s7ok4uw	4401	19	role	role	NN
cord-001835-0s7ok4uw	4401	20	in	in	IN
cord-001835-0s7ok4uw	4401	21	the	the	DT
cord-001835-0s7ok4uw	4401	22	regulation	regulation	NN
cord-001835-0s7ok4uw	4401	23	and	and	CC
cord-001835-0s7ok4uw	4401	24	activation	activation	NN
cord-001835-0s7ok4uw	4401	25	of	of	IN
cord-001835-0s7ok4uw	4401	26	genes	gene	NNS
cord-001835-0s7ok4uw	4401	27	.	.	.
cord-001835-0s7ok4uw	4402	1	The	the	DT
cord-001835-0s7ok4uw	4402	2	failure	failure	NN
cord-001835-0s7ok4uw	4402	3	to	to	TO
cord-001835-0s7ok4uw	4402	4	regulate	regulate	VB
cord-001835-0s7ok4uw	4402	5	this	this	DT
cord-001835-0s7ok4uw	4402	6	process	process	NN
cord-001835-0s7ok4uw	4402	7	correctly	correctly	RB
cord-001835-0s7ok4uw	4402	8	is	be	VBZ
cord-001835-0s7ok4uw	4402	9	a	a	DT
cord-001835-0s7ok4uw	4402	10	key	key	JJ
cord-001835-0s7ok4uw	4402	11	step	step	NN
cord-001835-0s7ok4uw	4402	12	in	in	IN
cord-001835-0s7ok4uw	4402	13	the	the	DT
cord-001835-0s7ok4uw	4402	14	development	development	NN
cord-001835-0s7ok4uw	4402	15	of	of	IN
cord-001835-0s7ok4uw	4402	16	several	several	JJ
cord-001835-0s7ok4uw	4402	17	endocrine	endocrine	NN
cord-001835-0s7ok4uw	4402	18	-	-	HYPH
cord-001835-0s7ok4uw	4402	19	driven	drive	VBN
cord-001835-0s7ok4uw	4402	20	cancers	cancer	NNS
cord-001835-0s7ok4uw	4402	21	.	.	.
cord-001835-0s7ok4uw	4403	1	For	for	IN
cord-001835-0s7ok4uw	4403	2	example	example	NN
cord-001835-0s7ok4uw	4403	3	:	:	:
cord-001835-0s7ok4uw	4403	4	oestrogen	oestrogen	NN
cord-001835-0s7ok4uw	4403	5	receptor	receptor	NN
cord-001835-0s7ok4uw	4403	6	positive	positive	JJ
cord-001835-0s7ok4uw	4403	7	(	(	-LRB-
cord-001835-0s7ok4uw	4403	8	ER1	ER1	NNP
cord-001835-0s7ok4uw	4403	9	)	)	-RRB-
cord-001835-0s7ok4uw	4403	10	breast	breast	NN
cord-001835-0s7ok4uw	4403	11	cancer	cancer	NN
cord-001835-0s7ok4uw	4403	12	is	be	VBZ
cord-001835-0s7ok4uw	4403	13	one	one	CD
cord-001835-0s7ok4uw	4403	14	of	of	IN
cord-001835-0s7ok4uw	4403	15	the	the	DT
cord-001835-0s7ok4uw	4403	16	most	most	RBS
cord-001835-0s7ok4uw	4403	17	common	common	JJ
cord-001835-0s7ok4uw	4403	18	forms	form	NNS
cord-001835-0s7ok4uw	4403	19	of	of	IN
cord-001835-0s7ok4uw	4403	20	cancer	cancer	NN
cord-001835-0s7ok4uw	4403	21	and	and	CC
cord-001835-0s7ok4uw	4403	22	accounts	account	NNS
cord-001835-0s7ok4uw	4403	23	for	for	IN
cord-001835-0s7ok4uw	4403	24	70	70	CD
cord-001835-0s7ok4uw	4403	25	%	%	NN
cord-001835-0s7ok4uw	4403	26	of	of	IN
cord-001835-0s7ok4uw	4403	27	all	all	DT
cord-001835-0s7ok4uw	4403	28	breast	breast	NN
cord-001835-0s7ok4uw	4403	29	cancer	cancer	NN
cord-001835-0s7ok4uw	4403	30	cases	case	NNS
cord-001835-0s7ok4uw	4403	31	.	.	.
cord-001835-0s7ok4uw	4404	1	In	in	IN
cord-001835-0s7ok4uw	4404	2	ER1	ER1	NNP
cord-001835-0s7ok4uw	4404	3	tumours	tumour	NNS
cord-001835-0s7ok4uw	4404	4	,	,	,
cord-001835-0s7ok4uw	4404	5	the	the	DT
cord-001835-0s7ok4uw	4404	6	oestrogen	oestrogen	NN
cord-001835-0s7ok4uw	4404	7	receptor	receptor	NN
cord-001835-0s7ok4uw	4404	8	(	(	-LRB-
cord-001835-0s7ok4uw	4404	9	ER	ER	NNP
cord-001835-0s7ok4uw	4404	10	)	)	-RRB-
cord-001835-0s7ok4uw	4404	11	drives	drive	VBZ
cord-001835-0s7ok4uw	4404	12	the	the	DT
cord-001835-0s7ok4uw	4404	13	tumour	tumour	NN
cord-001835-0s7ok4uw	4404	14	growth	growth	NN
cord-001835-0s7ok4uw	4404	15	and	and	CC
cord-001835-0s7ok4uw	4404	16	cell	cell	NN
cord-001835-0s7ok4uw	4404	17	proliferation	proliferation	NN
cord-001835-0s7ok4uw	4404	18	.	.	.
cord-001835-0s7ok4uw	4405	1	Understanding	understand	VBG
cord-001835-0s7ok4uw	4405	2	the	the	DT
cord-001835-0s7ok4uw	4405	3	interactions	interaction	NNS
cord-001835-0s7ok4uw	4405	4	of	of	IN
cord-001835-0s7ok4uw	4405	5	the	the	DT
cord-001835-0s7ok4uw	4405	6	ER	ER	NNP
cord-001835-0s7ok4uw	4405	7	with	with	IN
cord-001835-0s7ok4uw	4405	8	other	other	JJ
cord-001835-0s7ok4uw	4405	9	proteins	protein	NNS
cord-001835-0s7ok4uw	4405	10	,	,	,
cord-001835-0s7ok4uw	4405	11	either	either	CC
cord-001835-0s7ok4uw	4405	12	directly	directly	RB
cord-001835-0s7ok4uw	4405	13	or	or	CC
cord-001835-0s7ok4uw	4405	14	indirectly	indirectly	RB
cord-001835-0s7ok4uw	4405	15	,	,	,
cord-001835-0s7ok4uw	4405	16	can	can	MD
cord-001835-0s7ok4uw	4405	17	provide	provide	VB
cord-001835-0s7ok4uw	4405	18	vital	vital	JJ
cord-001835-0s7ok4uw	4405	19	insight	insight	NN
cord-001835-0s7ok4uw	4405	20	to	to	IN
cord-001835-0s7ok4uw	4405	21	the	the	DT
cord-001835-0s7ok4uw	4405	22	regulation	regulation	NN
cord-001835-0s7ok4uw	4405	23	of	of	IN
cord-001835-0s7ok4uw	4405	24	the	the	DT
cord-001835-0s7ok4uw	4405	25	system	system	NN
cord-001835-0s7ok4uw	4405	26	that	that	WDT
cord-001835-0s7ok4uw	4405	27	drives	drive	VBZ
cord-001835-0s7ok4uw	4405	28	this	this	DT
cord-001835-0s7ok4uw	4405	29	cancer	cancer	NN
cord-001835-0s7ok4uw	4405	30	.	.	.
cord-001835-0s7ok4uw	4406	1	The	the	DT
cord-001835-0s7ok4uw	4406	2	progesterone	progesterone	NN
cord-001835-0s7ok4uw	4406	3	receptor	receptor	NN
cord-001835-0s7ok4uw	4406	4	(	(	-LRB-
cord-001835-0s7ok4uw	4406	5	PR	PR	NNP
cord-001835-0s7ok4uw	4406	6	)	)	-RRB-
cord-001835-0s7ok4uw	4406	7	has	have	VBZ
cord-001835-0s7ok4uw	4406	8	also	also	RB
cord-001835-0s7ok4uw	4406	9	been	be	VBN
cord-001835-0s7ok4uw	4406	10	implicated	implicate	VBN
cord-001835-0s7ok4uw	4406	11	in	in	IN
cord-001835-0s7ok4uw	4406	12	breast	breast	NN
cord-001835-0s7ok4uw	4406	13	cancer	cancer	NN
cord-001835-0s7ok4uw	4406	14	,	,	,
cord-001835-0s7ok4uw	4406	15	and	and	CC
cord-001835-0s7ok4uw	4406	16	the	the	DT
cord-001835-0s7ok4uw	4406	17	androgen	androgen	NN
cord-001835-0s7ok4uw	4406	18	receptor	receptor	NN
cord-001835-0s7ok4uw	4406	19	(	(	-LRB-
cord-001835-0s7ok4uw	4406	20	AR	AR	NNP
cord-001835-0s7ok4uw	4406	21	)	)	-RRB-
cord-001835-0s7ok4uw	4406	22	is	be	VBZ
cord-001835-0s7ok4uw	4406	23	a	a	DT
cord-001835-0s7ok4uw	4406	24	known	know	VBN
cord-001835-0s7ok4uw	4406	25	driver	driver	NN
cord-001835-0s7ok4uw	4406	26	in	in	IN
cord-001835-0s7ok4uw	4406	27	the	the	DT
cord-001835-0s7ok4uw	4406	28	majority	majority	NN
cord-001835-0s7ok4uw	4406	29	of	of	IN
cord-001835-0s7ok4uw	4406	30	prostate	prostate	NN
cord-001835-0s7ok4uw	4406	31	cancers	cancer	NNS
cord-001835-0s7ok4uw	4406	32	.	.	.
cord-001835-0s7ok4uw	4407	1	To	to	TO
cord-001835-0s7ok4uw	4407	2	meet	meet	VB
cord-001835-0s7ok4uw	4407	3	the	the	DT
cord-001835-0s7ok4uw	4407	4	challenges	challenge	NNS
cord-001835-0s7ok4uw	4407	5	of	of	IN
cord-001835-0s7ok4uw	4407	6	elucidating	elucidate	VBG
cord-001835-0s7ok4uw	4407	7	these	these	DT
cord-001835-0s7ok4uw	4407	8	systems	system	NNS
cord-001835-0s7ok4uw	4407	9	,	,	,
cord-001835-0s7ok4uw	4407	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	4407	11	have	have	VBP
cord-001835-0s7ok4uw	4407	12	developed	develop	VBN
cord-001835-0s7ok4uw	4407	13	methods	method	NNS
cord-001835-0s7ok4uw	4407	14	to	to	TO
cord-001835-0s7ok4uw	4407	15	purify	purify	VB
cord-001835-0s7ok4uw	4407	16	and	and	CC
cord-001835-0s7ok4uw	4407	17	analyse	analyse	VB
cord-001835-0s7ok4uw	4407	18	cross	cross	VB
cord-001835-0s7ok4uw	4407	19	-	-	JJ
cord-001835-0s7ok4uw	4407	20	linked	link	VBN
cord-001835-0s7ok4uw	4407	21	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	4407	22	complexes	complex	NNS
cord-001835-0s7ok4uw	4407	23	bound	bind	VBN
cord-001835-0s7ok4uw	4407	24	to	to	IN
cord-001835-0s7ok4uw	4407	25	DNA	DNA	NNP
cord-001835-0s7ok4uw	4407	26	by	by	IN
cord-001835-0s7ok4uw	4407	27	mass	mass	NN
cord-001835-0s7ok4uw	4407	28	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4407	29	(	(	-LRB-
cord-001835-0s7ok4uw	4407	30	ChIP	ChIP	NNP
cord-001835-0s7ok4uw	4407	31	-	-	HYPH
cord-001835-0s7ok4uw	4407	32	MS	MS	NNP
cord-001835-0s7ok4uw	4407	33	)	)	-RRB-
cord-001835-0s7ok4uw	4407	34	.	.	.
cord-001835-0s7ok4uw	4408	1	This	this	DT
cord-001835-0s7ok4uw	4408	2	allows	allow	VBZ
cord-001835-0s7ok4uw	4408	3	for	for	IN
cord-001835-0s7ok4uw	4408	4	the	the	DT
cord-001835-0s7ok4uw	4408	5	enrichment	enrichment	NN
cord-001835-0s7ok4uw	4408	6	of	of	IN
cord-001835-0s7ok4uw	4408	7	proteins	protein	NNS
cord-001835-0s7ok4uw	4408	8	involved	involve	VBN
cord-001835-0s7ok4uw	4408	9	in	in	IN
cord-001835-0s7ok4uw	4408	10	gene	gene	NN
cord-001835-0s7ok4uw	4408	11	regulation	regulation	NN
cord-001835-0s7ok4uw	4408	12	.	.	.
cord-001835-0s7ok4uw	4409	1	ChIP	ChIP	NNP
cord-001835-0s7ok4uw	4409	2	-	-	HYPH
cord-001835-0s7ok4uw	4409	3	MS	MS	NNP
cord-001835-0s7ok4uw	4409	4	,	,	,
cord-001835-0s7ok4uw	4409	5	combined	combine	VBN
cord-001835-0s7ok4uw	4409	6	with	with	IN
cord-001835-0s7ok4uw	4409	7	tandem	tandem	JJ
cord-001835-0s7ok4uw	4409	8	mass	mass	NN
cord-001835-0s7ok4uw	4409	9	tags	tag	NNS
cord-001835-0s7ok4uw	4409	10	(	(	-LRB-
cord-001835-0s7ok4uw	4409	11	TMT	TMT	NNP
cord-001835-0s7ok4uw	4409	12	)	)	-RRB-
cord-001835-0s7ok4uw	4409	13	,	,	,
cord-001835-0s7ok4uw	4409	14	makes	make	VBZ
cord-001835-0s7ok4uw	4409	15	it	-PRON-	PRP
cord-001835-0s7ok4uw	4409	16	possible	possible	JJ
cord-001835-0s7ok4uw	4409	17	to	to	TO
cord-001835-0s7ok4uw	4409	18	realise	realise	VB
cord-001835-0s7ok4uw	4409	19	a	a	DT
cord-001835-0s7ok4uw	4409	20	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	4409	21	method	method	NN
cord-001835-0s7ok4uw	4409	22	to	to	TO
cord-001835-0s7ok4uw	4409	23	investigate	investigate	VB
cord-001835-0s7ok4uw	4409	24	the	the	DT
cord-001835-0s7ok4uw	4409	25	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	4409	26	network	network	NN
cord-001835-0s7ok4uw	4409	27	of	of	IN
cord-001835-0s7ok4uw	4409	28	interactions	interaction	NNS
cord-001835-0s7ok4uw	4409	29	between	between	IN
cord-001835-0s7ok4uw	4409	30	proteins	protein	NNS
cord-001835-0s7ok4uw	4409	31	within	within	IN
cord-001835-0s7ok4uw	4409	32	complexes	complex	NNS
cord-001835-0s7ok4uw	4409	33	that	that	WDT
cord-001835-0s7ok4uw	4409	34	undertake	undertake	VBP
cord-001835-0s7ok4uw	4409	35	the	the	DT
cord-001835-0s7ok4uw	4409	36	regulation	regulation	NN
cord-001835-0s7ok4uw	4409	37	of	of	IN
cord-001835-0s7ok4uw	4409	38	biological	biological	JJ
cord-001835-0s7ok4uw	4409	39	systems	system	NNS
cord-001835-0s7ok4uw	4409	40	.	.	.
cord-001835-0s7ok4uw	4410	1	ChIP	chip	NN
cord-001835-0s7ok4uw	4410	2	-	-	HYPH
cord-001835-0s7ok4uw	4410	3	seq	seq	NNP
cord-001835-0s7ok4uw	4410	4	is	be	VBZ
cord-001835-0s7ok4uw	4410	5	a	a	DT
cord-001835-0s7ok4uw	4410	6	well	well	RB
cord-001835-0s7ok4uw	4410	7	-	-	HYPH
cord-001835-0s7ok4uw	4410	8	established	establish	VBN
cord-001835-0s7ok4uw	4410	9	method	method	NN
cord-001835-0s7ok4uw	4410	10	for	for	IN
cord-001835-0s7ok4uw	4410	11	identifying	identify	VBG
cord-001835-0s7ok4uw	4410	12	where	where	WRB
cord-001835-0s7ok4uw	4410	13	these	these	DT
cord-001835-0s7ok4uw	4410	14	protein	protein	NN
cord-001835-0s7ok4uw	4410	15	complexes	complex	NNS
cord-001835-0s7ok4uw	4410	16	are	be	VBP
cord-001835-0s7ok4uw	4410	17	bound	bind	VBN
cord-001835-0s7ok4uw	4410	18	to	to	IN
cord-001835-0s7ok4uw	4410	19	the	the	DT
cord-001835-0s7ok4uw	4410	20	genome	genome	NN
cord-001835-0s7ok4uw	4410	21	.	.	.
cord-001835-0s7ok4uw	4411	1	This	this	DT
cord-001835-0s7ok4uw	4411	2	work	work	NN
cord-001835-0s7ok4uw	4411	3	focuses	focus	VBZ
cord-001835-0s7ok4uw	4411	4	on	on	IN
cord-001835-0s7ok4uw	4411	5	how	how	WRB
cord-001835-0s7ok4uw	4411	6	to	to	TO
cord-001835-0s7ok4uw	4411	7	combine	combine	VB
cord-001835-0s7ok4uw	4411	8	these	these	DT
cord-001835-0s7ok4uw	4411	9	technologies	technology	NNS
cord-001835-0s7ok4uw	4411	10	with	with	IN
cord-001835-0s7ok4uw	4411	11	my	-PRON-	PRP$
cord-001835-0s7ok4uw	4411	12	previous	previous	JJ
cord-001835-0s7ok4uw	4411	13	development	development	NN
cord-001835-0s7ok4uw	4411	14	of	of	IN
cord-001835-0s7ok4uw	4411	15	cross	cross	JJ
cord-001835-0s7ok4uw	4411	16	-	-	JJ
cord-001835-0s7ok4uw	4411	17	linking	link	VBG
cord-001835-0s7ok4uw	4411	18	coupled	coupled	JJ
cord-001835-0s7ok4uw	4411	19	mass	mass	NN
cord-001835-0s7ok4uw	4411	20	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4411	21	techniques	technique	NNS
cord-001835-0s7ok4uw	4411	22	(	(	-LRB-
cord-001835-0s7ok4uw	4411	23	XCMS	XCMS	NNP
cord-001835-0s7ok4uw	4411	24	)	)	-RRB-
cord-001835-0s7ok4uw	4411	25	to	to	TO
cord-001835-0s7ok4uw	4411	26	provide	provide	VB
cord-001835-0s7ok4uw	4411	27	a	a	DT
cord-001835-0s7ok4uw	4411	28	strategy	strategy	NN
cord-001835-0s7ok4uw	4411	29	for	for	IN
cord-001835-0s7ok4uw	4411	30	visualising	visualise	VBG
cord-001835-0s7ok4uw	4411	31	the	the	DT
cord-001835-0s7ok4uw	4411	32	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	4411	33	organisation	organisation	NN
cord-001835-0s7ok4uw	4411	34	of	of	IN
cord-001835-0s7ok4uw	4411	35	the	the	DT
cord-001835-0s7ok4uw	4411	36	proteins	protein	NNS
cord-001835-0s7ok4uw	4411	37	on	on	IN
cord-001835-0s7ok4uw	4411	38	the	the	DT
cord-001835-0s7ok4uw	4411	39	chromatin	chromatin	NN
cord-001835-0s7ok4uw	4411	40	.	.	.
cord-001835-0s7ok4uw	4412	1	Global	global	JJ
cord-001835-0s7ok4uw	4412	2	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	4412	3	analysis	analysis	NN
cord-001835-0s7ok4uw	4412	4	of	of	IN
cord-001835-0s7ok4uw	4412	5	caspase	caspase	NN
cord-001835-0s7ok4uw	4412	6	protein	protein	NN
cord-001835-0s7ok4uw	4412	7	substrates	substrate	NNS
cord-001835-0s7ok4uw	4412	8	in	in	IN
cord-001835-0s7ok4uw	4412	9	cell	cell	NN
cord-001835-0s7ok4uw	4412	10	lysate	lysate	NN
cord-001835-0s7ok4uw	4412	11	reveals	reveal	VBZ
cord-001835-0s7ok4uw	4412	12	selective	selective	JJ
cord-001835-0s7ok4uw	4412	13	roles	role	NNS
cord-001835-0s7ok4uw	4412	14	and	and	CC
cord-001835-0s7ok4uw	4412	15	target	target	VB
cord-001835-0s7ok4uw	4412	16	specificity	specificity	NN
cord-001835-0s7ok4uw	4412	17	Olivier	Olivier	NNP
cord-001835-0s7ok4uw	4412	18	Julien	Julien	NNP
cord-001835-0s7ok4uw	4412	19	1	1	CD
cord-001835-0s7ok4uw	4412	20	,	,	,
cord-001835-0s7ok4uw	4412	21	Min	Min	NNP
cord-001835-0s7ok4uw	4412	22	Zhuang	Zhuang	NNP
cord-001835-0s7ok4uw	4412	23	1	1	CD
cord-001835-0s7ok4uw	4412	24	,	,	,
cord-001835-0s7ok4uw	4412	25	Arun	Arun	NNP
cord-001835-0s7ok4uw	4412	26	Wiita	Wiita	NNP
cord-001835-0s7ok4uw	4412	27	1	1	CD
cord-001835-0s7ok4uw	4412	28	,	,	,
cord-001835-0s7ok4uw	4412	29	James	James	NNP
cord-001835-0s7ok4uw	4412	30	Wells	Wells	NNP
cord-001835-0s7ok4uw	4412	31	1	1	CD
cord-001835-0s7ok4uw	4412	32	1	1	CD
cord-001835-0s7ok4uw	4412	33	Caspases	Caspases	NNPS
cord-001835-0s7ok4uw	4412	34	are	be	VBP
cord-001835-0s7ok4uw	4412	35	cysteine	cysteine	NN
cord-001835-0s7ok4uw	4412	36	proteases	protease	NNS
cord-001835-0s7ok4uw	4412	37	that	that	WDT
cord-001835-0s7ok4uw	4412	38	play	play	VBP
cord-001835-0s7ok4uw	4412	39	important	important	JJ
cord-001835-0s7ok4uw	4412	40	roles	role	NNS
cord-001835-0s7ok4uw	4412	41	in	in	IN
cord-001835-0s7ok4uw	4412	42	development	development	NN
cord-001835-0s7ok4uw	4412	43	,	,	,
cord-001835-0s7ok4uw	4412	44	cell	cell	NN
cord-001835-0s7ok4uw	4412	45	differentiation	differentiation	NN
cord-001835-0s7ok4uw	4412	46	and	and	CC
cord-001835-0s7ok4uw	4412	47	cell	cell	NN
cord-001835-0s7ok4uw	4412	48	death	death	NN
cord-001835-0s7ok4uw	4412	49	.	.	.
cord-001835-0s7ok4uw	4413	1	However	however	RB
cord-001835-0s7ok4uw	4413	2	,	,	,
cord-001835-0s7ok4uw	4413	3	the	the	DT
cord-001835-0s7ok4uw	4413	4	limited	limited	JJ
cord-001835-0s7ok4uw	4413	5	number	number	NN
cord-001835-0s7ok4uw	4413	6	of	of	IN
cord-001835-0s7ok4uw	4413	7	known	know	VBN
cord-001835-0s7ok4uw	4413	8	caspase	caspase	NN
cord-001835-0s7ok4uw	4413	9	substrates	substrate	NNS
cord-001835-0s7ok4uw	4413	10	hinders	hinder	VBZ
cord-001835-0s7ok4uw	4413	11	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4413	12	understanding	understanding	NN
cord-001835-0s7ok4uw	4413	13	of	of	IN
cord-001835-0s7ok4uw	4413	14	caspase	caspase	NN
cord-001835-0s7ok4uw	4413	15	function	function	NN
cord-001835-0s7ok4uw	4413	16	.	.	.
cord-001835-0s7ok4uw	4414	1	Here	here	RB
cord-001835-0s7ok4uw	4414	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	4414	3	performed	perform	VBD
cord-001835-0s7ok4uw	4414	4	a	a	DT
cord-001835-0s7ok4uw	4414	5	non	non	JJ
cord-001835-0s7ok4uw	4414	6	-	-	JJ
cord-001835-0s7ok4uw	4414	7	biased	biased	JJ
cord-001835-0s7ok4uw	4414	8	identification	identification	NN
cord-001835-0s7ok4uw	4414	9	and	and	CC
cord-001835-0s7ok4uw	4414	10	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	4414	11	analysis	analysis	NN
cord-001835-0s7ok4uw	4414	12	of	of	IN
cord-001835-0s7ok4uw	4414	13	caspase-2	caspase-2	NNP
cord-001835-0s7ok4uw	4414	14	and	and	CC
cord-001835-0s7ok4uw	4414	15	caspase-6	caspase-6	NNP
cord-001835-0s7ok4uw	4414	16	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	4414	17	substrates	substrate	NNS
cord-001835-0s7ok4uw	4414	18	in	in	IN
cord-001835-0s7ok4uw	4414	19	cell	cell	NN
cord-001835-0s7ok4uw	4414	20	lysate	lysate	NN
cord-001835-0s7ok4uw	4414	21	,	,	,
cord-001835-0s7ok4uw	4414	22	using	use	VBG
cord-001835-0s7ok4uw	4414	23	an	an	DT
cord-001835-0s7ok4uw	4414	24	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	4414	25	N	N	NNP
cord-001835-0s7ok4uw	4414	26	-	-	HYPH
cord-001835-0s7ok4uw	4414	27	termini	termini	NN
cord-001835-0s7ok4uw	4414	28	enrichment	enrichment	NN
cord-001835-0s7ok4uw	4414	29	approach	approach	NN
cord-001835-0s7ok4uw	4414	30	followed	follow	VBN
cord-001835-0s7ok4uw	4414	31	by	by	IN
cord-001835-0s7ok4uw	4414	32	mass	mass	NN
cord-001835-0s7ok4uw	4414	33	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4414	34	.	.	.
cord-001835-0s7ok4uw	4415	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4415	2	identified	identify	VBD
cord-001835-0s7ok4uw	4415	3	235	235	CD
cord-001835-0s7ok4uw	4415	4	and	and	CC
cord-001835-0s7ok4uw	4415	5	871	871	CD
cord-001835-0s7ok4uw	4415	6	potential	potential	JJ
cord-001835-0s7ok4uw	4415	7	substrates	substrate	NNS
cord-001835-0s7ok4uw	4415	8	for	for	IN
cord-001835-0s7ok4uw	4415	9	the	the	DT
cord-001835-0s7ok4uw	4415	10	initiator	initiator	NN
cord-001835-0s7ok4uw	4415	11	caspase-2	caspase-2	NNP
cord-001835-0s7ok4uw	4415	12	and	and	CC
cord-001835-0s7ok4uw	4415	13	putative	putative	JJ
cord-001835-0s7ok4uw	4415	14	executioner	executioner	NN
cord-001835-0s7ok4uw	4415	15	caspase-6	caspase-6	NNP
cord-001835-0s7ok4uw	4415	16	,	,	,
cord-001835-0s7ok4uw	4415	17	respectively	respectively	RB
cord-001835-0s7ok4uw	4415	18	.	.	.
cord-001835-0s7ok4uw	4416	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4416	2	results	result	NNS
cord-001835-0s7ok4uw	4416	3	not	not	RB
cord-001835-0s7ok4uw	4416	4	only	only	RB
cord-001835-0s7ok4uw	4416	5	confirm	confirm	VBP
cord-001835-0s7ok4uw	4416	6	known	know	VBN
cord-001835-0s7ok4uw	4416	7	substrates	substrate	NNS
cord-001835-0s7ok4uw	4416	8	but	but	CC
cord-001835-0s7ok4uw	4416	9	also	also	RB
cord-001835-0s7ok4uw	4416	10	identify	identify	VBP
cord-001835-0s7ok4uw	4416	11	many	many	JJ
cord-001835-0s7ok4uw	4416	12	more	more	JJR
cord-001835-0s7ok4uw	4416	13	new	new	JJ
cord-001835-0s7ok4uw	4416	14	substrates	substrate	NNS
cord-001835-0s7ok4uw	4416	15	with	with	IN
cord-001835-0s7ok4uw	4416	16	the	the	DT
cord-001835-0s7ok4uw	4416	17	precise	precise	JJ
cord-001835-0s7ok4uw	4416	18	location	location	NN
cord-001835-0s7ok4uw	4416	19	of	of	IN
cord-001835-0s7ok4uw	4416	20	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	4416	21	.	.	.
cord-001835-0s7ok4uw	4417	1	Given	give	VBN
cord-001835-0s7ok4uw	4417	2	the	the	DT
cord-001835-0s7ok4uw	4417	3	emerging	emerge	VBG
cord-001835-0s7ok4uw	4417	4	roles	role	NNS
cord-001835-0s7ok4uw	4417	5	of	of	IN
cord-001835-0s7ok4uw	4417	6	caspases-2	caspases-2	NNP
cord-001835-0s7ok4uw	4417	7	and	and	CC
cord-001835-0s7ok4uw	4417	8	26	26	CD
cord-001835-0s7ok4uw	4417	9	in	in	IN
cord-001835-0s7ok4uw	4417	10	inflammation	inflammation	NN
cord-001835-0s7ok4uw	4417	11	and	and	CC
cord-001835-0s7ok4uw	4417	12	neurodegeneration	neurodegeneration	NN
cord-001835-0s7ok4uw	4417	13	,	,	,
cord-001835-0s7ok4uw	4417	14	these	these	DT
cord-001835-0s7ok4uw	4417	15	new	new	JJ
cord-001835-0s7ok4uw	4417	16	substrates	substrate	NNS
cord-001835-0s7ok4uw	4417	17	may	may	MD
cord-001835-0s7ok4uw	4417	18	provide	provide	VB
cord-001835-0s7ok4uw	4417	19	molecular	molecular	JJ
cord-001835-0s7ok4uw	4417	20	insight	insight	NN
cord-001835-0s7ok4uw	4417	21	into	into	IN
cord-001835-0s7ok4uw	4417	22	the	the	DT
cord-001835-0s7ok4uw	4417	23	progression	progression	NN
cord-001835-0s7ok4uw	4417	24	of	of	IN
cord-001835-0s7ok4uw	4417	25	related	related	JJ
cord-001835-0s7ok4uw	4417	26	diseases	disease	NNS
cord-001835-0s7ok4uw	4417	27	.	.	.
cord-001835-0s7ok4uw	4418	1	The	the	DT
cord-001835-0s7ok4uw	4418	2	sequence	sequence	NN
cord-001835-0s7ok4uw	4418	3	consensus	consensus	NN
cord-001835-0s7ok4uw	4418	4	logo	logo	NN
cord-001835-0s7ok4uw	4418	5	of	of	IN
cord-001835-0s7ok4uw	4418	6	caspase-2	caspase-2	NNP
cord-001835-0s7ok4uw	4418	7	targets	target	NNS
cord-001835-0s7ok4uw	4418	8	was	be	VBD
cord-001835-0s7ok4uw	4418	9	very	very	RB
cord-001835-0s7ok4uw	4418	10	similar	similar	JJ
cord-001835-0s7ok4uw	4418	11	to	to	IN
cord-001835-0s7ok4uw	4418	12	a	a	DT
cord-001835-0s7ok4uw	4418	13	classical	classical	JJ
cord-001835-0s7ok4uw	4418	14	executioner	executioner	NN
cord-001835-0s7ok4uw	4418	15	caspase	caspase	NN
cord-001835-0s7ok4uw	4418	16	motif	motif	NN
cord-001835-0s7ok4uw	4418	17	(	(	-LRB-
cord-001835-0s7ok4uw	4418	18	DEVD	DEVD	NNP
cord-001835-0s7ok4uw	4418	19	)	)	-RRB-
cord-001835-0s7ok4uw	4418	20	,	,	,
cord-001835-0s7ok4uw	4418	21	while	while	IN
cord-001835-0s7ok4uw	4418	22	caspase-6	caspase-6	NNP
cord-001835-0s7ok4uw	4418	23	revealed	reveal	VBD
cord-001835-0s7ok4uw	4418	24	a	a	DT
cord-001835-0s7ok4uw	4418	25	VEVD	VEVD	NNP
cord-001835-0s7ok4uw	4418	26	motif	motif	NN
cord-001835-0s7ok4uw	4418	27	.	.	.
cord-001835-0s7ok4uw	4419	1	Using	use	VBG
cord-001835-0s7ok4uw	4419	2	selected	select	VBN
cord-001835-0s7ok4uw	4419	3	reaction	reaction	NN
cord-001835-0s7ok4uw	4419	4	monitoring	monitoring	NN
cord-001835-0s7ok4uw	4419	5	(	(	-LRB-
cord-001835-0s7ok4uw	4419	6	SRM	SRM	NNP
cord-001835-0s7ok4uw	4419	7	)	)	-RRB-
cord-001835-0s7ok4uw	4419	8	,	,	,
cord-001835-0s7ok4uw	4419	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	4419	10	quantified	quantify	VBD
cord-001835-0s7ok4uw	4419	11	the	the	DT
cord-001835-0s7ok4uw	4419	12	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	4419	13	of	of	IN
cord-001835-0s7ok4uw	4419	14	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	4419	15	of	of	IN
cord-001835-0s7ok4uw	4419	16	a	a	DT
cord-001835-0s7ok4uw	4419	17	large	large	JJ
cord-001835-0s7ok4uw	4419	18	subset	subset	NN
cord-001835-0s7ok4uw	4419	19	of	of	IN
cord-001835-0s7ok4uw	4419	20	these	these	DT
cord-001835-0s7ok4uw	4419	21	substrates	substrate	NNS
cord-001835-0s7ok4uw	4419	22	by	by	IN
cord-001835-0s7ok4uw	4419	23	measuring	measure	VBG
cord-001835-0s7ok4uw	4419	24	the	the	DT
cord-001835-0s7ok4uw	4419	25	appearance	appearance	NN
cord-001835-0s7ok4uw	4419	26	of	of	IN
cord-001835-0s7ok4uw	4419	27	the	the	DT
cord-001835-0s7ok4uw	4419	28	caspase	caspase	NN
cord-001835-0s7ok4uw	4419	29	cleavage	cleavage	NN
cord-001835-0s7ok4uw	4419	30	product	product	NN
cord-001835-0s7ok4uw	4419	31	over	over	IN
cord-001835-0s7ok4uw	4419	32	time	time	NN
cord-001835-0s7ok4uw	4419	33	.	.	.
cord-001835-0s7ok4uw	4420	1	In	in	IN
cord-001835-0s7ok4uw	4420	2	the	the	DT
cord-001835-0s7ok4uw	4420	3	end	end	NN
cord-001835-0s7ok4uw	4420	4	,	,	,
cord-001835-0s7ok4uw	4420	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4420	6	measured	measure	VBD
cord-001835-0s7ok4uw	4420	7	50	50	CD
cord-001835-0s7ok4uw	4420	8	and	and	CC
cord-001835-0s7ok4uw	4420	9	276	276	CD
cord-001835-0s7ok4uw	4420	10	kcat	kcat	NNP
cord-001835-0s7ok4uw	4420	11	/	/	SYM
cord-001835-0s7ok4uw	4420	12	Km	Km	NNP
cord-001835-0s7ok4uw	4420	13	values	value	NNS
cord-001835-0s7ok4uw	4420	14	for	for	IN
cord-001835-0s7ok4uw	4420	15	individual	individual	JJ
cord-001835-0s7ok4uw	4420	16	substrates	substrate	NNS
cord-001835-0s7ok4uw	4420	17	cut	cut	VBN
cord-001835-0s7ok4uw	4420	18	by	by	IN
cord-001835-0s7ok4uw	4420	19	caspase-2	caspase-2	NNP
cord-001835-0s7ok4uw	4420	20	and	and	CC
cord-001835-0s7ok4uw	4420	21	caspase-6	caspase-6	NNP
cord-001835-0s7ok4uw	4420	22	,	,	,
cord-001835-0s7ok4uw	4420	23	respectively	respectively	RB
cord-001835-0s7ok4uw	4420	24	.	.	.
cord-001835-0s7ok4uw	4421	1	By	by	IN
cord-001835-0s7ok4uw	4421	2	comparing	compare	VBG
cord-001835-0s7ok4uw	4421	3	these	these	DT
cord-001835-0s7ok4uw	4421	4	data	datum	NNS
cord-001835-0s7ok4uw	4421	5	with	with	IN
cord-001835-0s7ok4uw	4421	6	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4421	7	previous	previous	JJ
cord-001835-0s7ok4uw	4421	8	analysis	analysis	NN
cord-001835-0s7ok4uw	4421	9	of	of	IN
cord-001835-0s7ok4uw	4421	10	caspase-3	caspase-3	NNP
cord-001835-0s7ok4uw	4421	11	,	,	,
cord-001835-0s7ok4uw	4421	12	27	27	CD
cord-001835-0s7ok4uw	4421	13	,	,	,
cord-001835-0s7ok4uw	4421	14	and	and	CC
cord-001835-0s7ok4uw	4421	15	28	28	CD
cord-001835-0s7ok4uw	4421	16	,	,	,
cord-001835-0s7ok4uw	4421	17	we	-PRON-	PRP
cord-001835-0s7ok4uw	4421	18	found	find	VBD
cord-001835-0s7ok4uw	4421	19	that	that	IN
cord-001835-0s7ok4uw	4421	20	substrates	substrate	NNS
cord-001835-0s7ok4uw	4421	21	that	that	WDT
cord-001835-0s7ok4uw	4421	22	are	be	VBP
cord-001835-0s7ok4uw	4421	23	shared	share	VBN
cord-001835-0s7ok4uw	4421	24	between	between	IN
cord-001835-0s7ok4uw	4421	25	caspases	caspase	NNS
cord-001835-0s7ok4uw	4421	26	are	be	VBP
cord-001835-0s7ok4uw	4421	27	often	often	RB
cord-001835-0s7ok4uw	4421	28	cleaved	cleave	VBN
cord-001835-0s7ok4uw	4421	29	at	at	IN
cord-001835-0s7ok4uw	4421	30	rates	rate	NNS
cord-001835-0s7ok4uw	4421	31	that	that	WDT
cord-001835-0s7ok4uw	4421	32	differ	differ	VBP
cord-001835-0s7ok4uw	4421	33	by	by	IN
cord-001835-0s7ok4uw	4421	34	orders	order	NNS
cord-001835-0s7ok4uw	4421	35	of	of	IN
cord-001835-0s7ok4uw	4421	36	magnitude	magnitude	NN
cord-001835-0s7ok4uw	4421	37	.	.	.
cord-001835-0s7ok4uw	4422	1	Thus	thus	RB
cord-001835-0s7ok4uw	4422	2	,	,	,
cord-001835-0s7ok4uw	4422	3	despite	despite	IN
cord-001835-0s7ok4uw	4422	4	having	have	VBG
cord-001835-0s7ok4uw	4422	5	nearly	nearly	RB
cord-001835-0s7ok4uw	4422	6	identical	identical	JJ
cord-001835-0s7ok4uw	4422	7	primary	primary	JJ
cord-001835-0s7ok4uw	4422	8	sequence	sequence	NN
cord-001835-0s7ok4uw	4422	9	motifs	motifs	NN
cord-001835-0s7ok4uw	4422	10	,	,	,
cord-001835-0s7ok4uw	4422	11	the	the	DT
cord-001835-0s7ok4uw	4422	12	caspases	caspase	NNS
cord-001835-0s7ok4uw	4422	13	exhibit	exhibit	VBP
cord-001835-0s7ok4uw	4422	14	remarkable	remarkable	JJ
cord-001835-0s7ok4uw	4422	15	substrate	substrate	NN
cord-001835-0s7ok4uw	4422	16	specificity	specificity	NN
cord-001835-0s7ok4uw	4422	17	that	that	WDT
cord-001835-0s7ok4uw	4422	18	may	may	MD
cord-001835-0s7ok4uw	4422	19	reflect	reflect	VB
cord-001835-0s7ok4uw	4422	20	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4422	21	specialized	specialize	VBN
cord-001835-0s7ok4uw	4422	22	roles	role	NNS
cord-001835-0s7ok4uw	4422	23	within	within	IN
cord-001835-0s7ok4uw	4422	24	the	the	DT
cord-001835-0s7ok4uw	4422	25	cell	cell	NN
cord-001835-0s7ok4uw	4422	26	.	.	.
cord-001835-0s7ok4uw	4423	1	The	the	DT
cord-001835-0s7ok4uw	4423	2	Rockefeller	Rockefeller	NNP
cord-001835-0s7ok4uw	4423	3	University	University	NNP
cord-001835-0s7ok4uw	4423	4	,	,	,
cord-001835-0s7ok4uw	4423	5	2	2	CD
cord-001835-0s7ok4uw	4423	6	New	New	NNP
cord-001835-0s7ok4uw	4423	7	York	York	NNP
cord-001835-0s7ok4uw	4423	8	University	University	NNP
cord-001835-0s7ok4uw	4423	9	School	School	NNP
cord-001835-0s7ok4uw	4423	10	of	of	IN
cord-001835-0s7ok4uw	4423	11	Medicine	Medicine	NNP
cord-001835-0s7ok4uw	4423	12	,	,	,
cord-001835-0s7ok4uw	4423	13	3	3	CD
cord-001835-0s7ok4uw	4423	14	Johns	Johns	NNP
cord-001835-0s7ok4uw	4423	15	Hopkins	Hopkins	NNP
cord-001835-0s7ok4uw	4423	16	University	University	NNP
cord-001835-0s7ok4uw	4423	17	School	School	NNP
cord-001835-0s7ok4uw	4423	18	of	of	IN
cord-001835-0s7ok4uw	4423	19	Medicine	Medicine	NNP
cord-001835-0s7ok4uw	4423	20	LINE-1	LINE-1	NNP
cord-001835-0s7ok4uw	4423	21	(	(	-LRB-
cord-001835-0s7ok4uw	4423	22	L1	L1	NNP
cord-001835-0s7ok4uw	4423	23	)	)	-RRB-
cord-001835-0s7ok4uw	4423	24	retrotransposons	retrotransposon	NNS
cord-001835-0s7ok4uw	4423	25	are	be	VBP
cord-001835-0s7ok4uw	4423	26	catalysts	catalyst	NNS
cord-001835-0s7ok4uw	4423	27	of	of	IN
cord-001835-0s7ok4uw	4423	28	evolution	evolution	NN
cord-001835-0s7ok4uw	4423	29	and	and	CC
cord-001835-0s7ok4uw	4423	30	disease	disease	NN
cord-001835-0s7ok4uw	4423	31	whose	whose	WP$
cord-001835-0s7ok4uw	4423	32	sequences	sequence	NNS
cord-001835-0s7ok4uw	4423	33	comprise	comprise	VBP
cord-001835-0s7ok4uw	4423	34	a	a	DT
cord-001835-0s7ok4uw	4423	35	significant	significant	JJ
cord-001835-0s7ok4uw	4423	36	proportion	proportion	NN
cord-001835-0s7ok4uw	4423	37	of	of	IN
cord-001835-0s7ok4uw	4423	38	the	the	DT
cord-001835-0s7ok4uw	4423	39	human	human	JJ
cord-001835-0s7ok4uw	4423	40	genome	genome	NN
cord-001835-0s7ok4uw	4423	41	.	.	.
cord-001835-0s7ok4uw	4424	1	Despite	despite	IN
cord-001835-0s7ok4uw	4424	2	tremendous	tremendous	JJ
cord-001835-0s7ok4uw	4424	3	influence	influence	NN
cord-001835-0s7ok4uw	4424	4	on	on	IN
cord-001835-0s7ok4uw	4424	5	genome	genome	NN
cord-001835-0s7ok4uw	4424	6	composition	composition	NN
cord-001835-0s7ok4uw	4424	7	,	,	,
cord-001835-0s7ok4uw	4424	8	L1	L1	NNP
cord-001835-0s7ok4uw	4424	9	RNAs	rna	NNS
cord-001835-0s7ok4uw	4424	10	only	only	RB
cord-001835-0s7ok4uw	4424	11	encode	encode	VBP
cord-001835-0s7ok4uw	4424	12	two	two	CD
cord-001835-0s7ok4uw	4424	13	proteins	protein	NNS
cord-001835-0s7ok4uw	4424	14	.	.	.
cord-001835-0s7ok4uw	4425	1	Consequently	consequently	RB
cord-001835-0s7ok4uw	4425	2	,	,	,
cord-001835-0s7ok4uw	4425	3	L1	L1	NNP
cord-001835-0s7ok4uw	4425	4	particles	particle	NNS
cord-001835-0s7ok4uw	4425	5	include	include	VBP
cord-001835-0s7ok4uw	4425	6	a	a	DT
cord-001835-0s7ok4uw	4425	7	combination	combination	NN
cord-001835-0s7ok4uw	4425	8	of	of	IN
cord-001835-0s7ok4uw	4425	9	permissive	permissive	JJ
cord-001835-0s7ok4uw	4425	10	host	host	NN
cord-001835-0s7ok4uw	4425	11	factors	factor	NNS
cord-001835-0s7ok4uw	4425	12	that	that	WDT
cord-001835-0s7ok4uw	4425	13	are	be	VBP
cord-001835-0s7ok4uw	4425	14	essential	essential	JJ
cord-001835-0s7ok4uw	4425	15	to	to	IN
cord-001835-0s7ok4uw	4425	16	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4425	17	lifecycle	lifecycle	NN
cord-001835-0s7ok4uw	4425	18	as	as	RB
cord-001835-0s7ok4uw	4425	19	well	well	RB
cord-001835-0s7ok4uw	4425	20	as	as	IN
cord-001835-0s7ok4uw	4425	21	repressive	repressive	JJ
cord-001835-0s7ok4uw	4425	22	factors	factor	NNS
cord-001835-0s7ok4uw	4425	23	that	that	WDT
cord-001835-0s7ok4uw	4425	24	constitute	constitute	VBP
cord-001835-0s7ok4uw	4425	25	defenses	defense	NNS
cord-001835-0s7ok4uw	4425	26	against	against	IN
cord-001835-0s7ok4uw	4425	27	L1	L1	NNP
cord-001835-0s7ok4uw	4425	28	's	's	POS
cord-001835-0s7ok4uw	4425	29	mutagenic	mutagenic	JJ
cord-001835-0s7ok4uw	4425	30	activity	activity	NN
cord-001835-0s7ok4uw	4425	31	.	.	.
cord-001835-0s7ok4uw	4426	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4426	2	previously	previously	RB
cord-001835-0s7ok4uw	4426	3	characterized	characterize	VBD
cord-001835-0s7ok4uw	4426	4	host	host	NN
cord-001835-0s7ok4uw	4426	5	proteins	protein	NNS
cord-001835-0s7ok4uw	4426	6	associated	associate	VBN
cord-001835-0s7ok4uw	4426	7	with	with	IN
cord-001835-0s7ok4uw	4426	8	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	4426	9	and	and	CC
cord-001835-0s7ok4uw	4426	10	natural	natural	JJ
cord-001835-0s7ok4uw	4426	11	human	human	JJ
cord-001835-0s7ok4uw	4426	12	L1	L1	NNP
cord-001835-0s7ok4uw	4426	13	retrotransposons	retrotransposon	NNS
cord-001835-0s7ok4uw	4426	14	,	,	,
cord-001835-0s7ok4uw	4426	15	as	as	IN
cord-001835-0s7ok4uw	4426	16	expressed	express	VBN
cord-001835-0s7ok4uw	4426	17	in	in	IN
cord-001835-0s7ok4uw	4426	18	cell	cell	NN
cord-001835-0s7ok4uw	4426	19	culture	culture	NN
cord-001835-0s7ok4uw	4426	20	,	,	,
cord-001835-0s7ok4uw	4426	21	using	use	VBG
cord-001835-0s7ok4uw	4426	22	a	a	DT
cord-001835-0s7ok4uw	4426	23	combination	combination	NN
cord-001835-0s7ok4uw	4426	24	of	of	IN
cord-001835-0s7ok4uw	4426	25	techniques	technique	NNS
cord-001835-0s7ok4uw	4426	26	including	include	VBG
cord-001835-0s7ok4uw	4426	27	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	4426	28	labeling	labeling	NN
cord-001835-0s7ok4uw	4426	29	and	and	CC
cord-001835-0s7ok4uw	4426	30	affinity	affinity	NN
cord-001835-0s7ok4uw	4426	31	proteomics	proteomic	NNS
cord-001835-0s7ok4uw	4426	32	.	.	.
cord-001835-0s7ok4uw	4427	1	To	to	TO
cord-001835-0s7ok4uw	4427	2	build	build	VB
cord-001835-0s7ok4uw	4427	3	on	on	IN
cord-001835-0s7ok4uw	4427	4	these	these	DT
cord-001835-0s7ok4uw	4427	5	analyses	analysis	NNS
cord-001835-0s7ok4uw	4427	6	,	,	,
cord-001835-0s7ok4uw	4427	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	4427	8	have	have	VBP
cord-001835-0s7ok4uw	4427	9	implemented	implement	VBN
cord-001835-0s7ok4uw	4427	10	a	a	DT
cord-001835-0s7ok4uw	4427	11	series	series	NN
cord-001835-0s7ok4uw	4427	12	of	of	IN
cord-001835-0s7ok4uw	4427	13	2D	2D	NNP
cord-001835-0s7ok4uw	4427	14	separations	separation	NNS
cord-001835-0s7ok4uw	4427	15	and	and	CC
cord-001835-0s7ok4uw	4427	16	post	post	JJ
cord-001835-0s7ok4uw	4427	17	-	-	JJ
cord-001835-0s7ok4uw	4427	18	purification	purification	JJ
cord-001835-0s7ok4uw	4427	19	treatments	treatment	NNS
cord-001835-0s7ok4uw	4427	20	to	to	TO
cord-001835-0s7ok4uw	4427	21	produce	produce	VB
cord-001835-0s7ok4uw	4427	22	a	a	DT
cord-001835-0s7ok4uw	4427	23	multi	multi	JJ
cord-001835-0s7ok4uw	4427	24	-	-	JJ
cord-001835-0s7ok4uw	4427	25	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	4427	26	interactomic	interactomic	JJ
cord-001835-0s7ok4uw	4427	27	characterization	characterization	NN
cord-001835-0s7ok4uw	4427	28	of	of	IN
cord-001835-0s7ok4uw	4427	29	affinity	affinity	NN
cord-001835-0s7ok4uw	4427	30	isolated	isolate	VBN
cord-001835-0s7ok4uw	4427	31	L1s	l1s	NN
cord-001835-0s7ok4uw	4427	32	.	.	.
cord-001835-0s7ok4uw	4428	1	These	these	DT
cord-001835-0s7ok4uw	4428	2	studies	study	NNS
cord-001835-0s7ok4uw	4428	3	have	have	VBP
cord-001835-0s7ok4uw	4428	4	revealed	reveal	VBN
cord-001835-0s7ok4uw	4428	5	the	the	DT
cord-001835-0s7ok4uw	4428	6	presence	presence	NN
cord-001835-0s7ok4uw	4428	7	of	of	IN
cord-001835-0s7ok4uw	4428	8	at	at	RB
cord-001835-0s7ok4uw	4428	9	least	least	RBS
cord-001835-0s7ok4uw	4428	10	two	two	CD
cord-001835-0s7ok4uw	4428	11	populations	population	NNS
cord-001835-0s7ok4uw	4428	12	of	of	IN
cord-001835-0s7ok4uw	4428	13	putative	putative	JJ
cord-001835-0s7ok4uw	4428	14	transposition	transposition	NN
cord-001835-0s7ok4uw	4428	15	intermediates	intermediate	NNS
cord-001835-0s7ok4uw	4428	16	that	that	WDT
cord-001835-0s7ok4uw	4428	17	may	may	MD
cord-001835-0s7ok4uw	4428	18	exhibit	exhibit	VB
cord-001835-0s7ok4uw	4428	19	distinctive	distinctive	JJ
cord-001835-0s7ok4uw	4428	20	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	4428	21	localizations	localization	NNS
cord-001835-0s7ok4uw	4428	22	.	.	.
cord-001835-0s7ok4uw	4429	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4429	2	report	report	VBP
cord-001835-0s7ok4uw	4429	3	a	a	DT
cord-001835-0s7ok4uw	4429	4	comprehensive	comprehensive	JJ
cord-001835-0s7ok4uw	4429	5	,	,	,
cord-001835-0s7ok4uw	4429	6	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	4429	7	survey	survey	NN
cord-001835-0s7ok4uw	4429	8	of	of	IN
cord-001835-0s7ok4uw	4429	9	the	the	DT
cord-001835-0s7ok4uw	4429	10	proteins	protein	NNS
cord-001835-0s7ok4uw	4429	11	partitioning	partition	VBG
cord-001835-0s7ok4uw	4429	12	within	within	IN
cord-001835-0s7ok4uw	4429	13	these	these	DT
cord-001835-0s7ok4uw	4429	14	distinct	distinct	JJ
cord-001835-0s7ok4uw	4429	15	L1	L1	NNP
cord-001835-0s7ok4uw	4429	16	populations	population	NNS
cord-001835-0s7ok4uw	4429	17	and	and	CC
cord-001835-0s7ok4uw	4429	18	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4429	19	associated	associate	VBN
cord-001835-0s7ok4uw	4429	20	in	in	IN
cord-001835-0s7ok4uw	4429	21	vitro	vitro	FW
cord-001835-0s7ok4uw	4429	22	activity	activity	NN
cord-001835-0s7ok4uw	4429	23	.	.	.
cord-001835-0s7ok4uw	4430	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4430	2	observations	observation	NNS
cord-001835-0s7ok4uw	4430	3	provide	provide	VBP
cord-001835-0s7ok4uw	4430	4	a	a	DT
cord-001835-0s7ok4uw	4430	5	basis	basis	NN
cord-001835-0s7ok4uw	4430	6	for	for	IN
cord-001835-0s7ok4uw	4430	7	the	the	DT
cord-001835-0s7ok4uw	4430	8	classification	classification	NN
cord-001835-0s7ok4uw	4430	9	of	of	IN
cord-001835-0s7ok4uw	4430	10	L1	L1	NNP
cord-001835-0s7ok4uw	4430	11	interactors	interactor	NNS
cord-001835-0s7ok4uw	4430	12	with	with	IN
cord-001835-0s7ok4uw	4430	13	respect	respect	NN
cord-001835-0s7ok4uw	4430	14	to	to	IN
cord-001835-0s7ok4uw	4430	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4430	16	physical	physical	JJ
cord-001835-0s7ok4uw	4430	17	and	and	CC
cord-001835-0s7ok4uw	4430	18	functional	functional	JJ
cord-001835-0s7ok4uw	4430	19	links	link	NNS
cord-001835-0s7ok4uw	4430	20	,	,	,
cord-001835-0s7ok4uw	4430	21	facilitating	facilitate	VBG
cord-001835-0s7ok4uw	4430	22	hypotheses	hypothesis	NNS
cord-001835-0s7ok4uw	4430	23	to	to	TO
cord-001835-0s7ok4uw	4430	24	direct	direct	VB
cord-001835-0s7ok4uw	4430	25	in	in	IN
cord-001835-0s7ok4uw	4430	26	vivo	vivo	NN
cord-001835-0s7ok4uw	4430	27	experimentation	experimentation	NN
cord-001835-0s7ok4uw	4430	28	.	.	.
cord-001835-0s7ok4uw	4431	1	Polyubiquitin	Polyubiquitin	NNP
cord-001835-0s7ok4uw	4431	2	recognition	recognition	NN
cord-001835-0s7ok4uw	4431	3	by	by	IN
cord-001835-0s7ok4uw	4431	4	continuous	continuous	JJ
cord-001835-0s7ok4uw	4431	5	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4431	6	binding	bind	VBG
cord-001835-0s7ok4uw	4431	7	domains	domain	NNS
cord-001835-0s7ok4uw	4431	8	of	of	IN
cord-001835-0s7ok4uw	4431	9	Rad18	Rad18	NNP
cord-001835-0s7ok4uw	4431	10	probed	probe	VBN
cord-001835-0s7ok4uw	4431	11	by	by	IN
cord-001835-0s7ok4uw	4431	12	modeling	model	VBG
cord-001835-0s7ok4uw	4431	13	,	,	,
cord-001835-0s7ok4uw	4431	14	small	small	JJ
cord-001835-0s7ok4uw	4431	15	-	-	HYPH
cord-001835-0s7ok4uw	4431	16	angle	angle	NN
cord-001835-0s7ok4uw	4431	17	X	x	NN
cord-001835-0s7ok4uw	4431	18	-	-	NN
cord-001835-0s7ok4uw	4431	19	ray	ray	NN
cord-001835-0s7ok4uw	4431	20	scattering	scattering	NN
cord-001835-0s7ok4uw	4431	21	and	and	CC
cord-001835-0s7ok4uw	4431	22	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	4431	23	Sangho	Sangho	NNP
cord-001835-0s7ok4uw	4431	24	Lee	Lee	NNP
cord-001835-0s7ok4uw	4431	25	1	1	CD
cord-001835-0s7ok4uw	4431	26	,	,	,
cord-001835-0s7ok4uw	4431	27	Trung	Trung	NNP
cord-001835-0s7ok4uw	4431	28	Thanh	Thanh	NNP
cord-001835-0s7ok4uw	4431	29	Thach	Thach	NNP
cord-001835-0s7ok4uw	4431	30	1	1	CD
cord-001835-0s7ok4uw	4431	31	,	,	,
cord-001835-0s7ok4uw	4431	32	Namsoo	Namsoo	NNP
cord-001835-0s7ok4uw	4431	33	Lee	Lee	NNP
cord-001835-0s7ok4uw	4431	34	1	1	CD
cord-001835-0s7ok4uw	4431	35	,	,	,
cord-001835-0s7ok4uw	4431	36	Donghyuk	Donghyuk	NNP
cord-001835-0s7ok4uw	4431	37	Shin	Shin	NNP
cord-001835-0s7ok4uw	4431	38	1	1	CD
cord-001835-0s7ok4uw	4431	39	,	,	,
cord-001835-0s7ok4uw	4431	40	Seungsu	Seungsu	NNP
cord-001835-0s7ok4uw	4431	41	Han	Han	NNP
cord-001835-0s7ok4uw	4431	42	1	1	CD
cord-001835-0s7ok4uw	4431	43	,	,	,
cord-001835-0s7ok4uw	4431	44	Gyuhee	Gyuhee	NNP
cord-001835-0s7ok4uw	4431	45	Kim	Kim	NNP
cord-001835-0s7ok4uw	4431	46	1	1	CD
cord-001835-0s7ok4uw	4431	47	,	,	,
cord-001835-0s7ok4uw	4431	48	Hongtae	Hongtae	NNP
cord-001835-0s7ok4uw	4431	49	Kim	Kim	NNP
cord-001835-0s7ok4uw	4432	1	1	1	CD
cord-001835-0s7ok4uw	4432	2	1	1	CD
cord-001835-0s7ok4uw	4432	3	Rad18	Rad18	NNP
cord-001835-0s7ok4uw	4432	4	is	be	VBZ
cord-001835-0s7ok4uw	4432	5	a	a	DT
cord-001835-0s7ok4uw	4432	6	key	key	JJ
cord-001835-0s7ok4uw	4432	7	protein	protein	NN
cord-001835-0s7ok4uw	4432	8	in	in	IN
cord-001835-0s7ok4uw	4432	9	double	double	JJ
cord-001835-0s7ok4uw	4432	10	-	-	HYPH
cord-001835-0s7ok4uw	4432	11	strand	strand	NN
cord-001835-0s7ok4uw	4432	12	break	break	NN
cord-001835-0s7ok4uw	4432	13	DNA	dna	NN
cord-001835-0s7ok4uw	4432	14	damage	damage	NN
cord-001835-0s7ok4uw	4432	15	response	response	NN
cord-001835-0s7ok4uw	4432	16	(	(	-LRB-
cord-001835-0s7ok4uw	4432	17	DDR	DDR	NNP
cord-001835-0s7ok4uw	4432	18	)	)	-RRB-
cord-001835-0s7ok4uw	4432	19	pathways	pathway	NNS
cord-001835-0s7ok4uw	4432	20	by	by	IN
cord-001835-0s7ok4uw	4432	21	recognizing	recognize	VBG
cord-001835-0s7ok4uw	4432	22	K63-linked	k63-linked	JJ
cord-001835-0s7ok4uw	4432	23	polyubiquitylated	polyubiquitylate	VBN
cord-001835-0s7ok4uw	4432	24	chromatin	chromatin	NN
cord-001835-0s7ok4uw	4432	25	proteins	protein	NNS
cord-001835-0s7ok4uw	4432	26	through	through	IN
cord-001835-0s7ok4uw	4432	27	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4432	28	bipartite	bipartite	JJ
cord-001835-0s7ok4uw	4432	29	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4432	30	binding	binding	NN
cord-001835-0s7ok4uw	4432	31	domains	domain	NNS
cord-001835-0s7ok4uw	4432	32	UBZ	UBZ	NNP
cord-001835-0s7ok4uw	4432	33	and	and	CC
cord-001835-0s7ok4uw	4432	34	LRM	LRM	NNP
cord-001835-0s7ok4uw	4432	35	with	with	IN
cord-001835-0s7ok4uw	4432	36	extra	extra	JJ
cord-001835-0s7ok4uw	4432	37	residues	residue	NNS
cord-001835-0s7ok4uw	4432	38	in	in	IN
cord-001835-0s7ok4uw	4432	39	between	between	IN
cord-001835-0s7ok4uw	4432	40	.	.	.
cord-001835-0s7ok4uw	4433	1	Rad18	Rad18	NNP
cord-001835-0s7ok4uw	4433	2	binds	bind	VBZ
cord-001835-0s7ok4uw	4433	3	K63-linked	K63-linked	NNP
cord-001835-0s7ok4uw	4433	4	polyubiquitin	polyubiquitin	NNS
cord-001835-0s7ok4uw	4433	5	chains	chain	NNS
cord-001835-0s7ok4uw	4433	6	as	as	RB
cord-001835-0s7ok4uw	4433	7	well	well	RB
cord-001835-0s7ok4uw	4433	8	as	as	IN
cord-001835-0s7ok4uw	4433	9	K48linked	K48linked	NNP
cord-001835-0s7ok4uw	4433	10	ones	one	NNS
cord-001835-0s7ok4uw	4433	11	and	and	CC
cord-001835-0s7ok4uw	4433	12	mono	mono	NN
cord-001835-0s7ok4uw	4433	13	-	-	HYPH
cord-001835-0s7ok4uw	4433	14	ubiquitin	ubiquitin	JJ
cord-001835-0s7ok4uw	4433	15	.	.	.
cord-001835-0s7ok4uw	4434	1	However	however	RB
cord-001835-0s7ok4uw	4434	2	,	,	,
cord-001835-0s7ok4uw	4434	3	the	the	DT
cord-001835-0s7ok4uw	4434	4	detailed	detailed	JJ
cord-001835-0s7ok4uw	4434	5	molecular	molecular	JJ
cord-001835-0s7ok4uw	4434	6	basis	basis	NN
cord-001835-0s7ok4uw	4434	7	of	of	IN
cord-001835-0s7ok4uw	4434	8	polyubiquitin	polyubiquitin	NNP
cord-001835-0s7ok4uw	4434	9	recognition	recognition	NN
cord-001835-0s7ok4uw	4434	10	by	by	IN
cord-001835-0s7ok4uw	4434	11	UBZ	UBZ	NNP
cord-001835-0s7ok4uw	4434	12	and	and	CC
cord-001835-0s7ok4uw	4434	13	LRM	LRM	NNP
cord-001835-0s7ok4uw	4434	14	remains	remain	VBZ
cord-001835-0s7ok4uw	4434	15	unclear	unclear	JJ
cord-001835-0s7ok4uw	4434	16	.	.	.
cord-001835-0s7ok4uw	4435	1	Here	here	RB
cord-001835-0s7ok4uw	4435	2	,	,	,
cord-001835-0s7ok4uw	4435	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4435	4	examined	examine	VBD
cord-001835-0s7ok4uw	4435	5	the	the	DT
cord-001835-0s7ok4uw	4435	6	interaction	interaction	NN
cord-001835-0s7ok4uw	4435	7	of	of	IN
cord-001835-0s7ok4uw	4435	8	Rad18(201	Rad18(201	NNP
cord-001835-0s7ok4uw	4435	9	-	-	HYPH
cord-001835-0s7ok4uw	4435	10	240	240	CD
cord-001835-0s7ok4uw	4435	11	)	)	-RRB-
cord-001835-0s7ok4uw	4435	12	,	,	,
cord-001835-0s7ok4uw	4435	13	including	include	VBG
cord-001835-0s7ok4uw	4435	14	UBZ	UBZ	NNP
cord-001835-0s7ok4uw	4435	15	and	and	CC
cord-001835-0s7ok4uw	4435	16	LRM	LRM	NNP
cord-001835-0s7ok4uw	4435	17	,	,	,
cord-001835-0s7ok4uw	4435	18	with	with	IN
cord-001835-0s7ok4uw	4435	19	linear	linear	JJ
cord-001835-0s7ok4uw	4435	20	polyubiquitin	polyubiquitin	NNP
cord-001835-0s7ok4uw	4435	21	chains	chain	NNS
cord-001835-0s7ok4uw	4435	22	that	that	WDT
cord-001835-0s7ok4uw	4435	23	are	be	VBP
cord-001835-0s7ok4uw	4435	24	structurally	structurally	RB
cord-001835-0s7ok4uw	4435	25	similar	similar	JJ
cord-001835-0s7ok4uw	4435	26	to	to	IN
cord-001835-0s7ok4uw	4435	27	the	the	DT
cord-001835-0s7ok4uw	4435	28	K63-linked	K63-linked	NNP
cord-001835-0s7ok4uw	4435	29	ones	one	NNS
cord-001835-0s7ok4uw	4435	30	.	.	.
cord-001835-0s7ok4uw	4436	1	Rad18(201	Rad18(201	NNP
cord-001835-0s7ok4uw	4436	2	-	-	HYPH
cord-001835-0s7ok4uw	4436	3	240	240	CD
cord-001835-0s7ok4uw	4436	4	)	)	-RRB-
cord-001835-0s7ok4uw	4436	5	binds	bind	VBZ
cord-001835-0s7ok4uw	4436	6	linear	linear	JJ
cord-001835-0s7ok4uw	4436	7	polyubiquitin	polyubiquitin	NNS
cord-001835-0s7ok4uw	4436	8	chains	chain	NNS
cord-001835-0s7ok4uw	4436	9	(	(	-LRB-
cord-001835-0s7ok4uw	4436	10	Ub2	ub2	CD
cord-001835-0s7ok4uw	4436	11	,	,	,
cord-001835-0s7ok4uw	4436	12	Ub3	ub3	CD
cord-001835-0s7ok4uw	4436	13	,	,	,
cord-001835-0s7ok4uw	4436	14	Ub4	ub4	CD
cord-001835-0s7ok4uw	4436	15	)	)	-RRB-
cord-001835-0s7ok4uw	4436	16	with	with	IN
cord-001835-0s7ok4uw	4436	17	similar	similar	JJ
cord-001835-0s7ok4uw	4436	18	affinity	affinity	NN
cord-001835-0s7ok4uw	4436	19	to	to	IN
cord-001835-0s7ok4uw	4436	20	a	a	DT
cord-001835-0s7ok4uw	4436	21	K63-linked	K63-linked	NNP
cord-001835-0s7ok4uw	4436	22	one	one	NN
cord-001835-0s7ok4uw	4436	23	for	for	IN
cord-001835-0s7ok4uw	4436	24	diubiquitin	diubiquitin	NNP
cord-001835-0s7ok4uw	4436	25	.	.	.
cord-001835-0s7ok4uw	4437	1	Ab	ab	NN
cord-001835-0s7ok4uw	4437	2	initio	initio	JJ
cord-001835-0s7ok4uw	4437	3	modeling	modeling	NN
cord-001835-0s7ok4uw	4437	4	suggests	suggest	VBZ
cord-001835-0s7ok4uw	4437	5	that	that	IN
cord-001835-0s7ok4uw	4437	6	LRM	LRM	NNP
cord-001835-0s7ok4uw	4437	7	and	and	CC
cord-001835-0s7ok4uw	4437	8	the	the	DT
cord-001835-0s7ok4uw	4437	9	extra	extra	JJ
cord-001835-0s7ok4uw	4437	10	residues	residue	NNS
cord-001835-0s7ok4uw	4437	11	at	at	IN
cord-001835-0s7ok4uw	4437	12	the	the	DT
cord-001835-0s7ok4uw	4437	13	C	c	NN
cord-001835-0s7ok4uw	4437	14	-	-	HYPH
cord-001835-0s7ok4uw	4437	15	terminus	terminus	NN
cord-001835-0s7ok4uw	4437	16	of	of	IN
cord-001835-0s7ok4uw	4437	17	UBZ	UBZ	NNP
cord-001835-0s7ok4uw	4437	18	(	(	-LRB-
cord-001835-0s7ok4uw	4437	19	residues	residue	NNS
cord-001835-0s7ok4uw	4437	20	227	227	CD
cord-001835-0s7ok4uw	4437	21	-	-	SYM
cord-001835-0s7ok4uw	4437	22	237	237	CD
cord-001835-0s7ok4uw	4437	23	)	)	-RRB-
cord-001835-0s7ok4uw	4437	24	likely	likely	RB
cord-001835-0s7ok4uw	4437	25	form	form	VBP
cord-001835-0s7ok4uw	4437	26	a	a	DT
cord-001835-0s7ok4uw	4437	27	continuous	continuous	JJ
cord-001835-0s7ok4uw	4437	28	helix	helix	NN
cord-001835-0s7ok4uw	4437	29	,	,	,
cord-001835-0s7ok4uw	4437	30	termed	term	VBD
cord-001835-0s7ok4uw	4437	31	'	'	``
cord-001835-0s7ok4uw	4437	32	extended	extended	JJ
cord-001835-0s7ok4uw	4437	33	LR	lr	NN
cord-001835-0s7ok4uw	4437	34	motif	motif	NN
cord-001835-0s7ok4uw	4437	35	'	'	''
cord-001835-0s7ok4uw	4437	36	(	(	-LRB-
cord-001835-0s7ok4uw	4437	37	ELRM	ELRM	NNP
cord-001835-0s7ok4uw	4437	38	)	)	-RRB-
cord-001835-0s7ok4uw	4437	39	.	.	.
cord-001835-0s7ok4uw	4438	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4438	2	obtained	obtain	VBD
cord-001835-0s7ok4uw	4438	3	a	a	DT
cord-001835-0s7ok4uw	4438	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	4438	5	envelope	envelope	NN
cord-001835-0s7ok4uw	4438	6	for	for	IN
cord-001835-0s7ok4uw	4438	7	Rad18	Rad18	NNP
cord-001835-0s7ok4uw	4438	8	UBZ	UBZ	NNP
cord-001835-0s7ok4uw	4438	9	-	-	HYPH
cord-001835-0s7ok4uw	4438	10	ELRM	ELRM	NNS
cord-001835-0s7ok4uw	4438	11	:	:	:
cord-001835-0s7ok4uw	4438	12	linear	linear	VB
cord-001835-0s7ok4uw	4438	13	Ub2	ub2	CD
cord-001835-0s7ok4uw	4438	14	by	by	IN
cord-001835-0s7ok4uw	4438	15	small	small	JJ
cord-001835-0s7ok4uw	4438	16	-	-	HYPH
cord-001835-0s7ok4uw	4438	17	angle	angle	NN
cord-001835-0s7ok4uw	4438	18	X	x	NN
cord-001835-0s7ok4uw	4438	19	-	-	NN
cord-001835-0s7ok4uw	4438	20	ray	ray	NN
cord-001835-0s7ok4uw	4438	21	scattering	scattering	NN
cord-001835-0s7ok4uw	4438	22	and	and	CC
cord-001835-0s7ok4uw	4438	23	derived	derive	VBD
cord-001835-0s7ok4uw	4438	24	a	a	DT
cord-001835-0s7ok4uw	4438	25	structural	structural	JJ
cord-001835-0s7ok4uw	4438	26	model	model	NN
cord-001835-0s7ok4uw	4438	27	for	for	IN
cord-001835-0s7ok4uw	4438	28	the	the	DT
cord-001835-0s7ok4uw	4438	29	complex	complex	NN
cord-001835-0s7ok4uw	4438	30	.	.	.
cord-001835-0s7ok4uw	4439	1	The	the	DT
cord-001835-0s7ok4uw	4439	2	Rad18	Rad18	NNP
cord-001835-0s7ok4uw	4439	3	:	:	:
cord-001835-0s7ok4uw	4440	1	linear	linear	JJ
cord-001835-0s7ok4uw	4440	2	Ub2	Ub2	NNP
cord-001835-0s7ok4uw	4440	3	model	model	NN
cord-001835-0s7ok4uw	4440	4	indicates	indicate	VBZ
cord-001835-0s7ok4uw	4440	5	that	that	IN
cord-001835-0s7ok4uw	4440	6	ELRM	ELRM	NNP
cord-001835-0s7ok4uw	4440	7	enhances	enhance	VBZ
cord-001835-0s7ok4uw	4440	8	the	the	DT
cord-001835-0s7ok4uw	4440	9	binding	binding	NN
cord-001835-0s7ok4uw	4440	10	of	of	IN
cord-001835-0s7ok4uw	4440	11	Rad18	Rad18	NNP
cord-001835-0s7ok4uw	4440	12	with	with	IN
cord-001835-0s7ok4uw	4440	13	linear	linear	JJ
cord-001835-0s7ok4uw	4440	14	polyubiquitin	polyubiquitin	NNS
cord-001835-0s7ok4uw	4440	15	by	by	IN
cord-001835-0s7ok4uw	4440	16	contacting	contact	VBG
cord-001835-0s7ok4uw	4440	17	the	the	DT
cord-001835-0s7ok4uw	4440	18	proximal	proximal	JJ
cord-001835-0s7ok4uw	4440	19	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4440	20	moiety	moiety	NN
cord-001835-0s7ok4uw	4440	21	.	.	.
cord-001835-0s7ok4uw	4441	1	Consistent	consistent	JJ
cord-001835-0s7ok4uw	4441	2	with	with	IN
cord-001835-0s7ok4uw	4441	3	the	the	DT
cord-001835-0s7ok4uw	4441	4	structural	structural	JJ
cord-001835-0s7ok4uw	4441	5	analysis	analysis	NN
cord-001835-0s7ok4uw	4441	6	,	,	,
cord-001835-0s7ok4uw	4441	7	mutational	mutational	JJ
cord-001835-0s7ok4uw	4441	8	studies	study	NNS
cord-001835-0s7ok4uw	4441	9	showed	show	VBD
cord-001835-0s7ok4uw	4441	10	that	that	IN
cord-001835-0s7ok4uw	4441	11	residues	residue	NNS
cord-001835-0s7ok4uw	4441	12	in	in	IN
cord-001835-0s7ok4uw	4441	13	ELRM	ELRM	NNS
cord-001835-0s7ok4uw	4441	14	affect	affect	VBP
cord-001835-0s7ok4uw	4441	15	binding	bind	VBG
cord-001835-0s7ok4uw	4441	16	with	with	IN
cord-001835-0s7ok4uw	4441	17	linear	linear	JJ
cord-001835-0s7ok4uw	4441	18	Ub2	ub2	CD
cord-001835-0s7ok4uw	4441	19	,	,	,
cord-001835-0s7ok4uw	4441	20	not	not	RB
cord-001835-0s7ok4uw	4441	21	monoubiquitin	monoubiquitin	NNP
cord-001835-0s7ok4uw	4441	22	.	.	.
cord-001835-0s7ok4uw	4442	1	In	in	IN
cord-001835-0s7ok4uw	4442	2	cell	cell	NN
cord-001835-0s7ok4uw	4442	3	data	datum	NNS
cord-001835-0s7ok4uw	4442	4	support	support	NN
cord-001835-0s7ok4uw	4442	5	that	that	IN
cord-001835-0s7ok4uw	4442	6	ELRM	ELRM	NNP
cord-001835-0s7ok4uw	4442	7	is	be	VBZ
cord-001835-0s7ok4uw	4442	8	crucial	crucial	JJ
cord-001835-0s7ok4uw	4442	9	in	in	IN
cord-001835-0s7ok4uw	4442	10	Rad18	Rad18	NNP
cord-001835-0s7ok4uw	4442	11	localization	localization	NN
cord-001835-0s7ok4uw	4442	12	to	to	IN
cord-001835-0s7ok4uw	4442	13	DNA	dna	NN
cord-001835-0s7ok4uw	4442	14	damage	damage	NN
cord-001835-0s7ok4uw	4442	15	sites	site	NNS
cord-001835-0s7ok4uw	4442	16	.	.	.
cord-001835-0s7ok4uw	4443	1	Specifically	specifically	RB
cord-001835-0s7ok4uw	4443	2	E227	e227	NN
cord-001835-0s7ok4uw	4443	3	seems	seem	VBZ
cord-001835-0s7ok4uw	4443	4	to	to	TO
cord-001835-0s7ok4uw	4443	5	be	be	VB
cord-001835-0s7ok4uw	4443	6	the	the	DT
cord-001835-0s7ok4uw	4443	7	most	most	RBS
cord-001835-0s7ok4uw	4443	8	critical	critical	JJ
cord-001835-0s7ok4uw	4443	9	in	in	IN
cord-001835-0s7ok4uw	4443	10	polyubiquitin	polyubiquitin	NNS
cord-001835-0s7ok4uw	4443	11	binding	binding	NN
cord-001835-0s7ok4uw	4443	12	and	and	CC
cord-001835-0s7ok4uw	4443	13	localization	localization	NN
cord-001835-0s7ok4uw	4443	14	to	to	IN
cord-001835-0s7ok4uw	4443	15	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	4443	16	foci	foci	NN
cord-001835-0s7ok4uw	4443	17	.	.	.
cord-001835-0s7ok4uw	4444	1	Finally	finally	RB
cord-001835-0s7ok4uw	4444	2	,	,	,
cord-001835-0s7ok4uw	4444	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4444	4	reveal	reveal	VBP
cord-001835-0s7ok4uw	4444	5	that	that	IN
cord-001835-0s7ok4uw	4444	6	the	the	DT
cord-001835-0s7ok4uw	4444	7	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4444	8	-	-	HYPH
cord-001835-0s7ok4uw	4444	9	binding	bind	VBG
cord-001835-0s7ok4uw	4444	10	domains	domain	NNS
cord-001835-0s7ok4uw	4444	11	of	of	IN
cord-001835-0s7ok4uw	4444	12	Rad18	Rad18	NNP
cord-001835-0s7ok4uw	4444	13	bind	bind	VBP
cord-001835-0s7ok4uw	4444	14	linear	linear	JJ
cord-001835-0s7ok4uw	4444	15	Ub2	ub2	NN
cord-001835-0s7ok4uw	4444	16	more	more	RBR
cord-001835-0s7ok4uw	4444	17	tightly	tightly	RB
cord-001835-0s7ok4uw	4444	18	than	than	IN
cord-001835-0s7ok4uw	4444	19	those	those	DT
cord-001835-0s7ok4uw	4444	20	of	of	IN
cord-001835-0s7ok4uw	4444	21	RAP80	RAP80	NNP
cord-001835-0s7ok4uw	4444	22	,	,	,
cord-001835-0s7ok4uw	4444	23	providing	provide	VBG
cord-001835-0s7ok4uw	4444	24	a	a	DT
cord-001835-0s7ok4uw	4444	25	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	4444	26	basis	basis	NN
cord-001835-0s7ok4uw	4444	27	for	for	IN
cord-001835-0s7ok4uw	4444	28	blockage	blockage	NN
cord-001835-0s7ok4uw	4444	29	of	of	IN
cord-001835-0s7ok4uw	4444	30	RAP80	RAP80	NNP
cord-001835-0s7ok4uw	4444	31	at	at	IN
cord-001835-0s7ok4uw	4444	32	DSB	DSB	NNP
cord-001835-0s7ok4uw	4444	33	sites	site	NNS
cord-001835-0s7ok4uw	4444	34	.	.	.
cord-001835-0s7ok4uw	4445	1	Taken	take	VBN
cord-001835-0s7ok4uw	4445	2	together	together	RB
cord-001835-0s7ok4uw	4445	3	,	,	,
cord-001835-0s7ok4uw	4445	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4445	5	data	datum	NNS
cord-001835-0s7ok4uw	4445	6	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	4445	7	that	that	IN
cord-001835-0s7ok4uw	4445	8	Rad18(201	Rad18(201	NNP
cord-001835-0s7ok4uw	4445	9	-	-	HYPH
cord-001835-0s7ok4uw	4445	10	240	240	CD
cord-001835-0s7ok4uw	4445	11	)	)	-RRB-
cord-001835-0s7ok4uw	4445	12	forms	form	VBZ
cord-001835-0s7ok4uw	4445	13	continuous	continuous	JJ
cord-001835-0s7ok4uw	4445	14	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4445	15	binding	binding	NN
cord-001835-0s7ok4uw	4445	16	domains	domain	NNS
cord-001835-0s7ok4uw	4445	17	,	,	,
cord-001835-0s7ok4uw	4445	18	comprising	comprise	VBG
cord-001835-0s7ok4uw	4445	19	UBZ	UBZ	NNP
cord-001835-0s7ok4uw	4445	20	and	and	CC
cord-001835-0s7ok4uw	4445	21	ELRM	ELRM	NNS
cord-001835-0s7ok4uw	4445	22	,	,	,
cord-001835-0s7ok4uw	4445	23	and	and	CC
cord-001835-0s7ok4uw	4445	24	provides	provide	VBZ
cord-001835-0s7ok4uw	4445	25	a	a	DT
cord-001835-0s7ok4uw	4445	26	structural	structural	JJ
cord-001835-0s7ok4uw	4445	27	framework	framework	NN
cord-001835-0s7ok4uw	4445	28	for	for	IN
cord-001835-0s7ok4uw	4445	29	polyubiquitin	polyubiquitin	NNP
cord-001835-0s7ok4uw	4445	30	recognition	recognition	NN
cord-001835-0s7ok4uw	4445	31	by	by	IN
cord-001835-0s7ok4uw	4445	32	Rad18	Rad18	NNP
cord-001835-0s7ok4uw	4445	33	in	in	IN
cord-001835-0s7ok4uw	4445	34	the	the	DT
cord-001835-0s7ok4uw	4445	35	DDR	ddr	NN
cord-001835-0s7ok4uw	4445	36	pathway	pathway	NN
cord-001835-0s7ok4uw	4445	37	at	at	IN
cord-001835-0s7ok4uw	4445	38	a	a	DT
cord-001835-0s7ok4uw	4445	39	molecular	molecular	JJ
cord-001835-0s7ok4uw	4445	40	level	level	NN
cord-001835-0s7ok4uw	4445	41	.	.	.
cord-001835-0s7ok4uw	4446	1	Optimization	optimization	NN
cord-001835-0s7ok4uw	4446	2	of	of	IN
cord-001835-0s7ok4uw	4446	3	a	a	DT
cord-001835-0s7ok4uw	4446	4	protein	protein	NN
cord-001835-0s7ok4uw	4446	5	extraction	extraction	NN
cord-001835-0s7ok4uw	4446	6	method	method	NN
cord-001835-0s7ok4uw	4446	7	for	for	IN
cord-001835-0s7ok4uw	4446	8	the	the	DT
cord-001835-0s7ok4uw	4446	9	proteomic	proteomic	JJ
cord-001835-0s7ok4uw	4446	10	study	study	NN
cord-001835-0s7ok4uw	4446	11	of	of	IN
cord-001835-0s7ok4uw	4446	12	pozol	pozol	NNP
cord-001835-0s7ok4uw	4446	13	Cynthia	Cynthia	NNP
cord-001835-0s7ok4uw	4446	14	Teresa	Teresa	NNP
cord-001835-0s7ok4uw	4446	15	Leyva	Leyva	NNP
cord-001835-0s7ok4uw	4446	16	-	-	HYPH
cord-001835-0s7ok4uw	4446	17	Arguelles	Arguelles	NNP
cord-001835-0s7ok4uw	4446	18	1	1	CD
cord-001835-0s7ok4uw	4446	19	,	,	,
cord-001835-0s7ok4uw	4446	20	Carmen	Carmen	NNP
cord-001835-0s7ok4uw	4446	21	Wacher	Wacher	NNP
cord-001835-0s7ok4uw	4446	22	2	2	CD
cord-001835-0s7ok4uw	4446	23	,	,	,
cord-001835-0s7ok4uw	4446	24	Rosario	Rosario	NNP
cord-001835-0s7ok4uw	4446	25	Vera	Vera	NNP
cord-001835-0s7ok4uw	4446	26	3	3	CD
cord-001835-0s7ok4uw	4446	27	,	,	,
cord-001835-0s7ok4uw	4446	28	Romina	Romina	NNP
cord-001835-0s7ok4uw	4446	29	Rodr	Rodr	NNP
cord-001835-0s7ok4uw	4446	30	ıguez	ıguez	NNP
cord-001835-0s7ok4uw	4446	31	-	-	:
cord-001835-0s7ok4uw	4446	32	Sanoja	Sanoja	NNP
cord-001835-0s7ok4uw	4446	33	1	1	CD
cord-001835-0s7ok4uw	4446	34	1	1	CD
cord-001835-0s7ok4uw	4447	1	Instituto	Instituto	NNP
cord-001835-0s7ok4uw	4447	2	de	de	NNP
cord-001835-0s7ok4uw	4447	3	Investigaciones	Investigaciones	NNP
cord-001835-0s7ok4uw	4447	4	Biom	Biom	NNP
cord-001835-0s7ok4uw	4447	5	edicas	edicas	NN
cord-001835-0s7ok4uw	4447	6	,	,	,
cord-001835-0s7ok4uw	4447	7	UNAM	UNAM	NNP
cord-001835-0s7ok4uw	4447	8	.	.	NNP
cord-001835-0s7ok4uw	4447	9	,	,	,
cord-001835-0s7ok4uw	4447	10	2	2	CD
cord-001835-0s7ok4uw	4447	11	Facultad	Facultad	NNP
cord-001835-0s7ok4uw	4447	12	de	de	NNP
cord-001835-0s7ok4uw	4447	13	Qu	Qu	NNP
cord-001835-0s7ok4uw	4447	14	ımica	ımica	NNP
cord-001835-0s7ok4uw	4447	15	,	,	,
cord-001835-0s7ok4uw	4447	16	UNAM	UNAM	NNP
cord-001835-0s7ok4uw	4447	17	.	.	.
cord-001835-0s7ok4uw	4448	1	,	,	,
cord-001835-0s7ok4uw	4448	2	3	3	CD
cord-001835-0s7ok4uw	4448	3	Instituto	Instituto	NNP
cord-001835-0s7ok4uw	4448	4	de	de	NNP
cord-001835-0s7ok4uw	4448	5	Biotecnolog	Biotecnolog	NNP
cord-001835-0s7ok4uw	4448	6	ıa	ıa	NNS
cord-001835-0s7ok4uw	4448	7	,	,	,
cord-001835-0s7ok4uw	4448	8	UNAM	UNAM	NNP
cord-001835-0s7ok4uw	4448	9	Key	key	JJ
cord-001835-0s7ok4uw	4448	10	words	word	NNS
cord-001835-0s7ok4uw	4448	11	:	:	:
cord-001835-0s7ok4uw	4448	12	Proteomics	Proteomics	NNP
cord-001835-0s7ok4uw	4448	13	,	,	,
cord-001835-0s7ok4uw	4448	14	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4448	15	,	,	,
cord-001835-0s7ok4uw	4448	16	pozol	pozol	NNP
cord-001835-0s7ok4uw	4448	17	Pozol	Pozol	NNP
cord-001835-0s7ok4uw	4448	18	is	be	VBZ
cord-001835-0s7ok4uw	4448	19	a	a	DT
cord-001835-0s7ok4uw	4448	20	Mexican	mexican	JJ
cord-001835-0s7ok4uw	4448	21	traditional	traditional	JJ
cord-001835-0s7ok4uw	4448	22	no	no	DT
cord-001835-0s7ok4uw	4448	23	alcoholic	alcoholic	JJ
cord-001835-0s7ok4uw	4448	24	beverage	beverage	NN
cord-001835-0s7ok4uw	4448	25	elaborated	elaborate	VBN
cord-001835-0s7ok4uw	4448	26	by	by	IN
cord-001835-0s7ok4uw	4448	27	various	various	JJ
cord-001835-0s7ok4uw	4448	28	ethnic	ethnic	JJ
cord-001835-0s7ok4uw	4448	29	groups	group	NNS
cord-001835-0s7ok4uw	4448	30	in	in	IN
cord-001835-0s7ok4uw	4448	31	the	the	DT
cord-001835-0s7ok4uw	4448	32	southeastern	southeastern	NN
cord-001835-0s7ok4uw	4448	33	of	of	IN
cord-001835-0s7ok4uw	4448	34	Mexico	Mexico	NNP
cord-001835-0s7ok4uw	4448	35	.	.	.
cord-001835-0s7ok4uw	4449	1	Pozol	Pozol	NNP
cord-001835-0s7ok4uw	4449	2	is	be	VBZ
cord-001835-0s7ok4uw	4449	3	obtained	obtain	VBN
cord-001835-0s7ok4uw	4449	4	from	from	IN
cord-001835-0s7ok4uw	4449	5	the	the	DT
cord-001835-0s7ok4uw	4449	6	natural	natural	JJ
cord-001835-0s7ok4uw	4449	7	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4449	8	of	of	IN
cord-001835-0s7ok4uw	4449	9	nixtamal	nixtamal	NNP
cord-001835-0s7ok4uw	4449	10	(	(	-LRB-
cord-001835-0s7ok4uw	4449	11	heat	heat	NN
cord-001835-0s7ok4uw	4449	12	-	-	HYPH
cord-001835-0s7ok4uw	4449	13	and	and	CC
cord-001835-0s7ok4uw	4449	14	alkali	alkali	RB
cord-001835-0s7ok4uw	4449	15	-	-	HYPH
cord-001835-0s7ok4uw	4449	16	treated	treat	VBN
cord-001835-0s7ok4uw	4449	17	maize	maize	NN
cord-001835-0s7ok4uw	4449	18	)	)	-RRB-
cord-001835-0s7ok4uw	4449	19	dough	dough	NN
cord-001835-0s7ok4uw	4449	20	.	.	.
cord-001835-0s7ok4uw	4450	1	The	the	DT
cord-001835-0s7ok4uw	4450	2	main	main	JJ
cord-001835-0s7ok4uw	4450	3	carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	4450	4	in	in	IN
cord-001835-0s7ok4uw	4450	5	maize	maize	NN
cord-001835-0s7ok4uw	4450	6	dough	dough	NN
cord-001835-0s7ok4uw	4450	7	is	be	VBZ
cord-001835-0s7ok4uw	4450	8	starch	starch	NN
cord-001835-0s7ok4uw	4450	9	(	(	-LRB-
cord-001835-0s7ok4uw	4450	10	72	72	CD
cord-001835-0s7ok4uw	4450	11	-	-	SYM
cord-001835-0s7ok4uw	4450	12	73	73	CD
cord-001835-0s7ok4uw	4450	13	%	%	NN
cord-001835-0s7ok4uw	4450	14	)	)	-RRB-
cord-001835-0s7ok4uw	4450	15	,	,	,
cord-001835-0s7ok4uw	4450	16	because	because	IN
cord-001835-0s7ok4uw	4450	17	others	other	NNS
cord-001835-0s7ok4uw	4450	18	such	such	JJ
cord-001835-0s7ok4uw	4450	19	as	as	IN
cord-001835-0s7ok4uw	4450	20	sucrose	sucrose	NN
cord-001835-0s7ok4uw	4450	21	,	,	,
cord-001835-0s7ok4uw	4450	22	glucose	glucose	NN
cord-001835-0s7ok4uw	4450	23	and	and	CC
cord-001835-0s7ok4uw	4450	24	fructose	fructose	NN
cord-001835-0s7ok4uw	4450	25	are	be	VBP
cord-001835-0s7ok4uw	4450	26	mostly	mostly	RB
cord-001835-0s7ok4uw	4450	27	lost	lose	VBN
cord-001835-0s7ok4uw	4450	28	during	during	IN
cord-001835-0s7ok4uw	4450	29	nixtamalization	nixtamalization	NN
cord-001835-0s7ok4uw	4450	30	;	;	:
cord-001835-0s7ok4uw	4450	31	so	so	RB
cord-001835-0s7ok4uw	4450	32	,	,	,
cord-001835-0s7ok4uw	4450	33	the	the	DT
cord-001835-0s7ok4uw	4450	34	starch	starch	NN
cord-001835-0s7ok4uw	4450	35	remains	remain	VBZ
cord-001835-0s7ok4uw	4450	36	as	as	IN
cord-001835-0s7ok4uw	4450	37	the	the	DT
cord-001835-0s7ok4uw	4450	38	major	major	JJ
cord-001835-0s7ok4uw	4450	39	carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	4450	40	available	available	JJ
cord-001835-0s7ok4uw	4450	41	for	for	IN
cord-001835-0s7ok4uw	4450	42	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4450	43	[	[	-LRB-
cord-001835-0s7ok4uw	4450	44	1	1	CD
cord-001835-0s7ok4uw	4450	45	]	]	-RRB-
cord-001835-0s7ok4uw	4450	46	.	.	.
cord-001835-0s7ok4uw	4451	1	A	a	DT
cord-001835-0s7ok4uw	4451	2	wide	wide	JJ
cord-001835-0s7ok4uw	4451	3	variety	variety	NN
cord-001835-0s7ok4uw	4451	4	of	of	IN
cord-001835-0s7ok4uw	4451	5	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	4451	6	have	have	VBP
cord-001835-0s7ok4uw	4451	7	already	already	RB
cord-001835-0s7ok4uw	4451	8	been	be	VBN
cord-001835-0s7ok4uw	4451	9	isolated	isolate	VBN
cord-001835-0s7ok4uw	4451	10	from	from	IN
cord-001835-0s7ok4uw	4451	11	the	the	DT
cord-001835-0s7ok4uw	4451	12	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4451	13	of	of	IN
cord-001835-0s7ok4uw	4451	14	pozol	pozol	NN
cord-001835-0s7ok4uw	4451	15	;	;	:
cord-001835-0s7ok4uw	4451	16	these	these	DT
cord-001835-0s7ok4uw	4451	17	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	4451	18	include	include	VBP
cord-001835-0s7ok4uw	4451	19	fungi	fungus	NNS
cord-001835-0s7ok4uw	4451	20	,	,	,
cord-001835-0s7ok4uw	4451	21	yeasts	yeast	NNS
cord-001835-0s7ok4uw	4451	22	,	,	,
cord-001835-0s7ok4uw	4451	23	lactic	lactic	JJ
cord-001835-0s7ok4uw	4451	24	acid	acid	NN
cord-001835-0s7ok4uw	4451	25	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	4451	26	,	,	,
cord-001835-0s7ok4uw	4451	27	and	and	CC
cord-001835-0s7ok4uw	4451	28	non	non	JJ
cord-001835-0s7ok4uw	4451	29	-	-	JJ
cord-001835-0s7ok4uw	4451	30	lactic	lactic	JJ
cord-001835-0s7ok4uw	4451	31	acid	acid	NN
cord-001835-0s7ok4uw	4451	32	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	4451	33	[	[	-LRB-
cord-001835-0s7ok4uw	4451	34	2	2	CD
cord-001835-0s7ok4uw	4451	35	]	]	-RRB-
cord-001835-0s7ok4uw	4451	36	.	.	.
cord-001835-0s7ok4uw	4452	1	However	however	RB
cord-001835-0s7ok4uw	4452	2	,	,	,
cord-001835-0s7ok4uw	4452	3	only	only	RB
cord-001835-0s7ok4uw	4452	4	few	few	JJ
cord-001835-0s7ok4uw	4452	5	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	4452	6	are	be	VBP
cord-001835-0s7ok4uw	4452	7	amylolytic	amylolytic	VBN
cord-001835-0s7ok4uw	4452	8	in	in	IN
cord-001835-0s7ok4uw	4452	9	this	this	DT
cord-001835-0s7ok4uw	4452	10	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4452	11	and	and	CC
cord-001835-0s7ok4uw	4452	12	all	all	DT
cord-001835-0s7ok4uw	4452	13	of	of	IN
cord-001835-0s7ok4uw	4452	14	them	-PRON-	PRP
cord-001835-0s7ok4uw	4452	15	are	be	VBP
cord-001835-0s7ok4uw	4452	16	weakly	weakly	RB
cord-001835-0s7ok4uw	4452	17	amylolytic	amylolytic	JJ
cord-001835-0s7ok4uw	4452	18	[	[	-LRB-
cord-001835-0s7ok4uw	4452	19	1	1	CD
cord-001835-0s7ok4uw	4452	20	]	]	-RRB-
cord-001835-0s7ok4uw	4452	21	.	.	.
cord-001835-0s7ok4uw	4453	1	In	in	IN
cord-001835-0s7ok4uw	4453	2	an	an	DT
cord-001835-0s7ok4uw	4453	3	attempt	attempt	NN
cord-001835-0s7ok4uw	4453	4	to	to	TO
cord-001835-0s7ok4uw	4453	5	explain	explain	VB
cord-001835-0s7ok4uw	4453	6	how	how	WRB
cord-001835-0s7ok4uw	4453	7	a	a	DT
cord-001835-0s7ok4uw	4453	8	very	very	RB
cord-001835-0s7ok4uw	4453	9	low	low	JJ
cord-001835-0s7ok4uw	4453	10	content	content	NN
cord-001835-0s7ok4uw	4453	11	of	of	IN
cord-001835-0s7ok4uw	4453	12	soluble	soluble	JJ
cord-001835-0s7ok4uw	4453	13	sugars	sugar	NNS
cord-001835-0s7ok4uw	4453	14	can	can	MD
cord-001835-0s7ok4uw	4453	15	support	support	VB
cord-001835-0s7ok4uw	4453	16	a	a	DT
cord-001835-0s7ok4uw	4453	17	diverse	diverse	JJ
cord-001835-0s7ok4uw	4453	18	and	and	CC
cord-001835-0s7ok4uw	4453	19	abundant	abundant	JJ
cord-001835-0s7ok4uw	4453	20	microbiota	microbiota	NN
cord-001835-0s7ok4uw	4453	21	,	,	,
cord-001835-0s7ok4uw	4453	22	a	a	DT
cord-001835-0s7ok4uw	4453	23	proteomic	proteomic	JJ
cord-001835-0s7ok4uw	4453	24	approach	approach	NN
cord-001835-0s7ok4uw	4453	25	was	be	VBD
cord-001835-0s7ok4uw	4453	26	designed	design	VBN
cord-001835-0s7ok4uw	4453	27	to	to	TO
cord-001835-0s7ok4uw	4453	28	understand	understand	VB
cord-001835-0s7ok4uw	4453	29	the	the	DT
cord-001835-0s7ok4uw	4453	30	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4453	31	of	of	IN
cord-001835-0s7ok4uw	4453	32	pozol	pozol	NNP
cord-001835-0s7ok4uw	4453	33	[	[	-LRB-
cord-001835-0s7ok4uw	4453	34	3	3	CD
cord-001835-0s7ok4uw	4453	35	]	]	-RRB-
cord-001835-0s7ok4uw	4453	36	.	.	.
cord-001835-0s7ok4uw	4454	1	Nevertheless	nevertheless	RB
cord-001835-0s7ok4uw	4454	2	,	,	,
cord-001835-0s7ok4uw	4454	3	the	the	DT
cord-001835-0s7ok4uw	4454	4	extraction	extraction	NN
cord-001835-0s7ok4uw	4454	5	of	of	IN
cord-001835-0s7ok4uw	4454	6	proteins	protein	NNS
cord-001835-0s7ok4uw	4454	7	from	from	IN
cord-001835-0s7ok4uw	4454	8	pozol	pozol	NNP
cord-001835-0s7ok4uw	4454	9	remains	remain	VBZ
cord-001835-0s7ok4uw	4454	10	a	a	DT
cord-001835-0s7ok4uw	4454	11	limiting	limit	VBG
cord-001835-0s7ok4uw	4454	12	step	step	NN
cord-001835-0s7ok4uw	4454	13	in	in	IN
cord-001835-0s7ok4uw	4454	14	proteomic	proteomic	JJ
cord-001835-0s7ok4uw	4454	15	analysis	analysis	NN
cord-001835-0s7ok4uw	4454	16	mainly	mainly	RB
cord-001835-0s7ok4uw	4454	17	due	due	IN
cord-001835-0s7ok4uw	4454	18	to	to	IN
cord-001835-0s7ok4uw	4454	19	the	the	DT
cord-001835-0s7ok4uw	4454	20	complexity	complexity	NN
cord-001835-0s7ok4uw	4454	21	of	of	IN
cord-001835-0s7ok4uw	4454	22	the	the	DT
cord-001835-0s7ok4uw	4454	23	sample	sample	NN
cord-001835-0s7ok4uw	4454	24	.	.	.
cord-001835-0s7ok4uw	4455	1	On	on	IN
cord-001835-0s7ok4uw	4455	2	the	the	DT
cord-001835-0s7ok4uw	4455	3	basis	basis	NN
cord-001835-0s7ok4uw	4455	4	of	of	IN
cord-001835-0s7ok4uw	4455	5	the	the	DT
cord-001835-0s7ok4uw	4455	6	aforementioned	aforementioned	JJ
cord-001835-0s7ok4uw	4455	7	reasons	reason	NNS
cord-001835-0s7ok4uw	4455	8	,	,	,
cord-001835-0s7ok4uw	4455	9	the	the	DT
cord-001835-0s7ok4uw	4455	10	aim	aim	NN
cord-001835-0s7ok4uw	4455	11	of	of	IN
cord-001835-0s7ok4uw	4455	12	this	this	DT
cord-001835-0s7ok4uw	4455	13	work	work	NN
cord-001835-0s7ok4uw	4455	14	was	be	VBD
cord-001835-0s7ok4uw	4455	15	to	to	TO
cord-001835-0s7ok4uw	4455	16	obtain	obtain	VB
cord-001835-0s7ok4uw	4455	17	a	a	DT
cord-001835-0s7ok4uw	4455	18	suitable	suitable	JJ
cord-001835-0s7ok4uw	4455	19	extraction	extraction	NN
cord-001835-0s7ok4uw	4455	20	method	method	NN
cord-001835-0s7ok4uw	4455	21	of	of	IN
cord-001835-0s7ok4uw	4455	22	proteins	protein	NNS
cord-001835-0s7ok4uw	4455	23	for	for	IN
cord-001835-0s7ok4uw	4455	24	proteomic	proteomic	JJ
cord-001835-0s7ok4uw	4455	25	analysis	analysis	NN
cord-001835-0s7ok4uw	4455	26	.	.	.
cord-001835-0s7ok4uw	4456	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	4456	2	,	,	,
cord-001835-0s7ok4uw	4456	3	the	the	DT
cord-001835-0s7ok4uw	4456	4	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4456	5	of	of	IN
cord-001835-0s7ok4uw	4456	6	pozol	pozol	NNP
cord-001835-0s7ok4uw	4456	7	was	be	VBD
cord-001835-0s7ok4uw	4456	8	continued	continue	VBN
cord-001835-0s7ok4uw	4456	9	for	for	IN
cord-001835-0s7ok4uw	4456	10	48	48	CD
cord-001835-0s7ok4uw	4456	11	h	h	NN
cord-001835-0s7ok4uw	4456	12	and	and	CC
cord-001835-0s7ok4uw	4456	13	samples	sample	NNS
cord-001835-0s7ok4uw	4456	14	were	be	VBD
cord-001835-0s7ok4uw	4456	15	taken	take	VBN
cord-001835-0s7ok4uw	4456	16	at	at	IN
cord-001835-0s7ok4uw	4456	17	0	0	CD
cord-001835-0s7ok4uw	4456	18	,	,	,
cord-001835-0s7ok4uw	4456	19	9	9	CD
cord-001835-0s7ok4uw	4456	20	,	,	,
cord-001835-0s7ok4uw	4456	21	24	24	CD
cord-001835-0s7ok4uw	4456	22	and	and	CC
cord-001835-0s7ok4uw	4456	23	48	48	CD
cord-001835-0s7ok4uw	4456	24	h.	h.	NN
cord-001835-0s7ok4uw	4457	1	For	for	IN
cord-001835-0s7ok4uw	4457	2	each	each	DT
cord-001835-0s7ok4uw	4457	3	sample	sample	NN
cord-001835-0s7ok4uw	4457	4	,	,	,
cord-001835-0s7ok4uw	4457	5	the	the	DT
cord-001835-0s7ok4uw	4457	6	total	total	JJ
cord-001835-0s7ok4uw	4457	7	sugar	sugar	NN
cord-001835-0s7ok4uw	4457	8	content	content	NN
cord-001835-0s7ok4uw	4457	9	was	be	VBD
cord-001835-0s7ok4uw	4457	10	determined	determine	VBN
cord-001835-0s7ok4uw	4457	11	by	by	IN
cord-001835-0s7ok4uw	4457	12	the	the	DT
cord-001835-0s7ok4uw	4457	13	Dubois	Dubois	NNP
cord-001835-0s7ok4uw	4457	14	et	et	NNP
cord-001835-0s7ok4uw	4457	15	al	al	NNP
cord-001835-0s7ok4uw	4457	16	.	.	.
cord-001835-0s7ok4uw	4458	1	method	method	NN
cord-001835-0s7ok4uw	4458	2	[	[	-LRB-
cord-001835-0s7ok4uw	4458	3	4	4	CD
cord-001835-0s7ok4uw	4458	4	]	]	-RRB-
cord-001835-0s7ok4uw	4458	5	and	and	CC
cord-001835-0s7ok4uw	4458	6	protein	protein	NN
cord-001835-0s7ok4uw	4458	7	extraction	extraction	NN
cord-001835-0s7ok4uw	4458	8	was	be	VBD
cord-001835-0s7ok4uw	4458	9	performed	perform	VBN
cord-001835-0s7ok4uw	4458	10	by	by	IN
cord-001835-0s7ok4uw	4458	11	two	two	CD
cord-001835-0s7ok4uw	4458	12	methods	method	NNS
cord-001835-0s7ok4uw	4458	13	:	:	:
cord-001835-0s7ok4uw	4458	14	A	a	LS
cord-001835-0s7ok4uw	4458	15	)	)	-RRB-
cord-001835-0s7ok4uw	4458	16	Direct	direct	JJ
cord-001835-0s7ok4uw	4458	17	extraction	extraction	NN
cord-001835-0s7ok4uw	4458	18	from	from	IN
cord-001835-0s7ok4uw	4458	19	the	the	DT
cord-001835-0s7ok4uw	4458	20	dough	dough	NN
cord-001835-0s7ok4uw	4458	21	[	[	-LRB-
cord-001835-0s7ok4uw	4458	22	3	3	CD
cord-001835-0s7ok4uw	4458	23	]	]	-RRB-
cord-001835-0s7ok4uw	4458	24	and	and	CC
cord-001835-0s7ok4uw	4458	25	B	b	NN
cord-001835-0s7ok4uw	4458	26	)	)	-RRB-
cord-001835-0s7ok4uw	4459	1	Initial	initial	JJ
cord-001835-0s7ok4uw	4459	2	extraction	extraction	NN
cord-001835-0s7ok4uw	4459	3	of	of	IN
cord-001835-0s7ok4uw	4459	4	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	4459	5	and	and	CC
cord-001835-0s7ok4uw	4459	6	soluble	soluble	JJ
cord-001835-0s7ok4uw	4459	7	proteins	protein	NNS
cord-001835-0s7ok4uw	4459	8	(	(	-LRB-
cord-001835-0s7ok4uw	4459	9	this	this	DT
cord-001835-0s7ok4uw	4459	10	work	work	NN
cord-001835-0s7ok4uw	4459	11	)	)	-RRB-
cord-001835-0s7ok4uw	4459	12	.	.	.
cord-001835-0s7ok4uw	4460	1	Comparison	comparison	NN
cord-001835-0s7ok4uw	4460	2	between	between	IN
cord-001835-0s7ok4uw	4460	3	the	the	DT
cord-001835-0s7ok4uw	4460	4	two	two	CD
cord-001835-0s7ok4uw	4460	5	protein	protein	NN
cord-001835-0s7ok4uw	4460	6	methods	method	NNS
cord-001835-0s7ok4uw	4460	7	was	be	VBD
cord-001835-0s7ok4uw	4460	8	performed	perform	VBN
cord-001835-0s7ok4uw	4460	9	on	on	IN
cord-001835-0s7ok4uw	4460	10	two	two	CD
cord-001835-0s7ok4uw	4460	11	-	-	HYPH
cord-001835-0s7ok4uw	4460	12	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	4460	13	gels	gel	NNS
cord-001835-0s7ok4uw	4460	14	with	with	IN
cord-001835-0s7ok4uw	4460	15	silver	silver	NN
cord-001835-0s7ok4uw	4460	16	stain	stain	NN
cord-001835-0s7ok4uw	4460	17	.	.	.
cord-001835-0s7ok4uw	4461	1	Then	then	RB
cord-001835-0s7ok4uw	4461	2	,	,	,
cord-001835-0s7ok4uw	4461	3	gels	gel	NNS
cord-001835-0s7ok4uw	4461	4	underwent	undergo	VBD
cord-001835-0s7ok4uw	4461	5	to	to	IN
cord-001835-0s7ok4uw	4461	6	image	image	NN
cord-001835-0s7ok4uw	4461	7	analysis	analysis	NN
cord-001835-0s7ok4uw	4461	8	by	by	IN
cord-001835-0s7ok4uw	4461	9	the	the	DT
cord-001835-0s7ok4uw	4461	10	image	image	NN
cord-001835-0s7ok4uw	4461	11	master	master	NN
cord-001835-0s7ok4uw	4461	12	2D	2D	NNP
cord-001835-0s7ok4uw	4461	13	Platinum	Platinum	NNP
cord-001835-0s7ok4uw	4461	14	software	software	NN
cord-001835-0s7ok4uw	4461	15	.	.	.
cord-001835-0s7ok4uw	4462	1	Comparing	compare	VBG
cord-001835-0s7ok4uw	4462	2	the	the	DT
cord-001835-0s7ok4uw	4462	3	2D	2d	NN
cord-001835-0s7ok4uw	4462	4	-	-	HYPH
cord-001835-0s7ok4uw	4462	5	gels	gel	NNS
cord-001835-0s7ok4uw	4462	6	,	,	,
cord-001835-0s7ok4uw	4462	7	more	more	JJR
cord-001835-0s7ok4uw	4462	8	proteins	protein	NNS
cord-001835-0s7ok4uw	4462	9	spots	spot	NNS
cord-001835-0s7ok4uw	4462	10	were	be	VBD
cord-001835-0s7ok4uw	4462	11	obtained	obtain	VBN
cord-001835-0s7ok4uw	4462	12	with	with	IN
cord-001835-0s7ok4uw	4462	13	method	method	NN
cord-001835-0s7ok4uw	4462	14	B	b	NN
cord-001835-0s7ok4uw	4462	15	than	than	IN
cord-001835-0s7ok4uw	4462	16	that	that	DT
cord-001835-0s7ok4uw	4462	17	with	with	IN
cord-001835-0s7ok4uw	4462	18	method	method	NN
cord-001835-0s7ok4uw	4462	19	A	A	NNP
cord-001835-0s7ok4uw	4462	20	,	,	,
cord-001835-0s7ok4uw	4462	21	indicating	indicate	VBG
cord-001835-0s7ok4uw	4462	22	a	a	DT
cord-001835-0s7ok4uw	4462	23	more	more	RBR
cord-001835-0s7ok4uw	4462	24	efficient	efficient	JJ
cord-001835-0s7ok4uw	4462	25	protein	protein	NN
cord-001835-0s7ok4uw	4462	26	extraction	extraction	NN
cord-001835-0s7ok4uw	4462	27	with	with	IN
cord-001835-0s7ok4uw	4462	28	method	method	NN
cord-001835-0s7ok4uw	4463	1	B.	B.	NNP
cord-001835-0s7ok4uw	4464	1	Although	although	IN
cord-001835-0s7ok4uw	4464	2	,	,	,
cord-001835-0s7ok4uw	4464	3	using	use	VBG
cord-001835-0s7ok4uw	4464	4	method	method	NN
cord-001835-0s7ok4uw	4464	5	A	a	DT
cord-001835-0s7ok4uw	4464	6	higher	high	JJR
cord-001835-0s7ok4uw	4464	7	concentration	concentration	NN
cord-001835-0s7ok4uw	4464	8	of	of	IN
cord-001835-0s7ok4uw	4464	9	total	total	JJ
cord-001835-0s7ok4uw	4464	10	proteins	protein	NNS
cord-001835-0s7ok4uw	4464	11	was	be	VBD
cord-001835-0s7ok4uw	4464	12	observed	observe	VBN
cord-001835-0s7ok4uw	4464	13	,	,	,
cord-001835-0s7ok4uw	4464	14	they	-PRON-	PRP
cord-001835-0s7ok4uw	4464	15	were	be	VBD
cord-001835-0s7ok4uw	4464	16	mostly	mostly	RB
cord-001835-0s7ok4uw	4464	17	maize	maize	NN
cord-001835-0s7ok4uw	4464	18	proteins	protein	NNS
cord-001835-0s7ok4uw	4464	19	,	,	,
cord-001835-0s7ok4uw	4464	20	that	that	IN
cord-001835-0s7ok4uw	4464	21	in	in	IN
cord-001835-0s7ok4uw	4464	22	turn	turn	NN
cord-001835-0s7ok4uw	4464	23	overlap	overlap	VBP
cord-001835-0s7ok4uw	4464	24	and	and	CC
cord-001835-0s7ok4uw	4464	25	reduce	reduce	VB
cord-001835-0s7ok4uw	4464	26	the	the	DT
cord-001835-0s7ok4uw	4464	27	efficiently	efficiently	RB
cord-001835-0s7ok4uw	4464	28	extraction	extraction	NN
cord-001835-0s7ok4uw	4464	29	of	of	IN
cord-001835-0s7ok4uw	4464	30	the	the	DT
cord-001835-0s7ok4uw	4464	31	microbial	microbial	JJ
cord-001835-0s7ok4uw	4464	32	low	low	JJ
cord-001835-0s7ok4uw	4464	33	abundant	abundant	JJ
cord-001835-0s7ok4uw	4464	34	proteins	protein	NNS
cord-001835-0s7ok4uw	4464	35	.	.	.
cord-001835-0s7ok4uw	4465	1	Then	then	RB
cord-001835-0s7ok4uw	4465	2	,	,	,
cord-001835-0s7ok4uw	4465	3	method	method	NN
cord-001835-0s7ok4uw	4465	4	B	B	NNP
cord-001835-0s7ok4uw	4465	5	allows	allow	VBZ
cord-001835-0s7ok4uw	4465	6	a	a	DT
cord-001835-0s7ok4uw	4465	7	better	well	JJR
cord-001835-0s7ok4uw	4465	8	extraction	extraction	NN
cord-001835-0s7ok4uw	4465	9	of	of	IN
cord-001835-0s7ok4uw	4465	10	those	those	DT
cord-001835-0s7ok4uw	4465	11	low	low	JJ
cord-001835-0s7ok4uw	4465	12	abundant	abundant	JJ
cord-001835-0s7ok4uw	4465	13	proteins	protein	NNS
cord-001835-0s7ok4uw	4465	14	and	and	CC
cord-001835-0s7ok4uw	4465	15	removes	remove	VBZ
cord-001835-0s7ok4uw	4465	16	sample	sample	NN
cord-001835-0s7ok4uw	4465	17	components	component	NNS
cord-001835-0s7ok4uw	4465	18	that	that	WDT
cord-001835-0s7ok4uw	4465	19	may	may	MD
cord-001835-0s7ok4uw	4465	20	interfere	interfere	VB
cord-001835-0s7ok4uw	4465	21	with	with	IN
cord-001835-0s7ok4uw	4465	22	the	the	DT
cord-001835-0s7ok4uw	4465	23	determination	determination	NN
cord-001835-0s7ok4uw	4465	24	.	.	.
cord-001835-0s7ok4uw	4466	1	These	these	DT
cord-001835-0s7ok4uw	4466	2	results	result	NNS
cord-001835-0s7ok4uw	4466	3	could	could	MD
cord-001835-0s7ok4uw	4466	4	help	help	VB
cord-001835-0s7ok4uw	4466	5	us	-PRON-	PRP
cord-001835-0s7ok4uw	4466	6	to	to	TO
cord-001835-0s7ok4uw	4466	7	find	find	VB
cord-001835-0s7ok4uw	4466	8	the	the	DT
cord-001835-0s7ok4uw	4466	9	proteins	protein	NNS
cord-001835-0s7ok4uw	4466	10	involved	involve	VBN
cord-001835-0s7ok4uw	4466	11	in	in	IN
cord-001835-0s7ok4uw	4466	12	carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	4466	13	metabolism	metabolism	NN
cord-001835-0s7ok4uw	4466	14	of	of	IN
cord-001835-0s7ok4uw	4466	15	the	the	DT
cord-001835-0s7ok4uw	4466	16	microbiota	microbiota	NN
cord-001835-0s7ok4uw	4466	17	and	and	CC
cord-001835-0s7ok4uw	4466	18	finally	finally	RB
cord-001835-0s7ok4uw	4466	19	elucidate	elucidate	VB
cord-001835-0s7ok4uw	4466	20	the	the	DT
cord-001835-0s7ok4uw	4466	21	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	4466	22	of	of	IN
cord-001835-0s7ok4uw	4466	23	pozol	pozol	JJ
cord-001835-0s7ok4uw	4466	24	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4466	25	.	.	.
cord-001835-0s7ok4uw	4467	1	Proteomics	Proteomics	NNP
cord-001835-0s7ok4uw	4467	2	has	have	VBZ
cord-001835-0s7ok4uw	4467	3	been	be	VBN
cord-001835-0s7ok4uw	4467	4	applied	apply	VBN
cord-001835-0s7ok4uw	4467	5	to	to	IN
cord-001835-0s7ok4uw	4467	6	the	the	DT
cord-001835-0s7ok4uw	4467	7	enology	enology	NN
cord-001835-0s7ok4uw	4467	8	field	field	NN
cord-001835-0s7ok4uw	4467	9	for	for	IN
cord-001835-0s7ok4uw	4467	10	numerous	numerous	JJ
cord-001835-0s7ok4uw	4467	11	purposes	purpose	NNS
cord-001835-0s7ok4uw	4467	12	including	include	VBG
cord-001835-0s7ok4uw	4467	13	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4467	14	control	control	NN
cord-001835-0s7ok4uw	4467	15	,	,	,
cord-001835-0s7ok4uw	4467	16	improvement	improvement	NN
cord-001835-0s7ok4uw	4467	17	of	of	IN
cord-001835-0s7ok4uw	4467	18	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4467	19	processes	process	NNS
cord-001835-0s7ok4uw	4467	20	,	,	,
cord-001835-0s7ok4uw	4467	21	ensuring	ensure	VBG
cord-001835-0s7ok4uw	4467	22	wine	wine	NN
cord-001835-0s7ok4uw	4467	23	quality	quality	NN
cord-001835-0s7ok4uw	4467	24	,	,	,
cord-001835-0s7ok4uw	4467	25	etc	etc	FW
cord-001835-0s7ok4uw	4467	26	.	.	.
cord-001835-0s7ok4uw	4468	1	According	accord	VBG
cord-001835-0s7ok4uw	4468	2	to	to	IN
cord-001835-0s7ok4uw	4468	3	Rodriguez	Rodriguez	NNP
cord-001835-0s7ok4uw	4468	4	et	et	NNP
cord-001835-0s7ok4uw	4468	5	al	al	NNP
cord-001835-0s7ok4uw	4468	6	.	.	NNP
cord-001835-0s7ok4uw	4468	7	,	,	,
cord-001835-0s7ok4uw	4468	8	(	(	-LRB-
cord-001835-0s7ok4uw	4468	9	2012	2012	CD
cord-001835-0s7ok4uw	4468	10	)	)	-RRB-
cord-001835-0s7ok4uw	4468	11	,	,	,
cord-001835-0s7ok4uw	4468	12	the	the	DT
cord-001835-0s7ok4uw	4468	13	information	information	NN
cord-001835-0s7ok4uw	4468	14	provided	provide	VBN
cord-001835-0s7ok4uw	4468	15	by	by	IN
cord-001835-0s7ok4uw	4468	16	wine	wine	NN
cord-001835-0s7ok4uw	4468	17	proteomics	proteomic	NNS
cord-001835-0s7ok4uw	4468	18	is	be	VBZ
cord-001835-0s7ok4uw	4468	19	not	not	RB
cord-001835-0s7ok4uw	4468	20	only	only	RB
cord-001835-0s7ok4uw	4468	21	useful	useful	JJ
cord-001835-0s7ok4uw	4468	22	for	for	IN
cord-001835-0s7ok4uw	4468	23	these	these	DT
cord-001835-0s7ok4uw	4468	24	intentions	intention	NNS
cord-001835-0s7ok4uw	4468	25	,	,	,
cord-001835-0s7ok4uw	4468	26	but	but	CC
cord-001835-0s7ok4uw	4468	27	also	also	RB
cord-001835-0s7ok4uw	4468	28	offers	offer	VBZ
cord-001835-0s7ok4uw	4468	29	excellent	excellent	JJ
cord-001835-0s7ok4uw	4468	30	prospects	prospect	NNS
cord-001835-0s7ok4uw	4468	31	for	for	IN
cord-001835-0s7ok4uw	4468	32	innovation	innovation	NN
cord-001835-0s7ok4uw	4468	33	and	and	CC
cord-001835-0s7ok4uw	4468	34	diversification	diversification	NN
cord-001835-0s7ok4uw	4468	35	of	of	IN
cord-001835-0s7ok4uw	4468	36	winemaking	winemaking	NN
cord-001835-0s7ok4uw	4468	37	processes	process	NNS
cord-001835-0s7ok4uw	4468	38	in	in	IN
cord-001835-0s7ok4uw	4468	39	the	the	DT
cord-001835-0s7ok4uw	4468	40	near	near	JJ
cord-001835-0s7ok4uw	4468	41	future	future	NN
cord-001835-0s7ok4uw	4468	42	.	.	.
cord-001835-0s7ok4uw	4469	1	In	in	IN
cord-001835-0s7ok4uw	4469	2	this	this	DT
cord-001835-0s7ok4uw	4469	3	context	context	NN
cord-001835-0s7ok4uw	4469	4	,	,	,
cord-001835-0s7ok4uw	4469	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4469	6	group	group	NN
cord-001835-0s7ok4uw	4469	7	has	have	VBZ
cord-001835-0s7ok4uw	4469	8	focused	focus	VBN
cord-001835-0s7ok4uw	4469	9	research	research	NN
cord-001835-0s7ok4uw	4469	10	on	on	IN
cord-001835-0s7ok4uw	4469	11	the	the	DT
cord-001835-0s7ok4uw	4469	12	identification	identification	NN
cord-001835-0s7ok4uw	4469	13	of	of	IN
cord-001835-0s7ok4uw	4469	14	proteins	protein	NNS
cord-001835-0s7ok4uw	4469	15	that	that	WDT
cord-001835-0s7ok4uw	4469	16	might	may	MD
cord-001835-0s7ok4uw	4469	17	be	be	VB
cord-001835-0s7ok4uw	4469	18	important	important	JJ
cord-001835-0s7ok4uw	4469	19	for	for	IN
cord-001835-0s7ok4uw	4469	20	yeast	yeast	NN
cord-001835-0s7ok4uw	4469	21	survival	survival	NN
cord-001835-0s7ok4uw	4469	22	under	under	IN
cord-001835-0s7ok4uw	4469	23	typical	typical	JJ
cord-001835-0s7ok4uw	4469	24	wine	wine	NN
cord-001835-0s7ok4uw	4469	25	elaboration	elaboration	NN
cord-001835-0s7ok4uw	4469	26	conditions	condition	NNS
cord-001835-0s7ok4uw	4469	27	(	(	-LRB-
cord-001835-0s7ok4uw	4469	28	standard	standard	JJ
cord-001835-0s7ok4uw	4469	29	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4469	30	,	,	,
cord-001835-0s7ok4uw	4469	31	Sherry	Sherry	NNP
cord-001835-0s7ok4uw	4469	32	wine	wine	NN
cord-001835-0s7ok4uw	4469	33	biological	biological	JJ
cord-001835-0s7ok4uw	4469	34	aging	age	VBG
cord-001835-0s7ok4uw	4469	35	and	and	CC
cord-001835-0s7ok4uw	4469	36	sparkling	sparkling	JJ
cord-001835-0s7ok4uw	4469	37	wine	wine	NN
cord-001835-0s7ok4uw	4469	38	second	second	JJ
cord-001835-0s7ok4uw	4469	39	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4469	40	)	)	-RRB-
cord-001835-0s7ok4uw	4469	41	as	as	RB
cord-001835-0s7ok4uw	4469	42	well	well	RB
cord-001835-0s7ok4uw	4469	43	as	as	IN
cord-001835-0s7ok4uw	4469	44	proteins	protein	NNS
cord-001835-0s7ok4uw	4469	45	that	that	WDT
cord-001835-0s7ok4uw	4469	46	configure	configure	VBP
cord-001835-0s7ok4uw	4469	47	the	the	DT
cord-001835-0s7ok4uw	4469	48	content	content	NN
cord-001835-0s7ok4uw	4469	49	of	of	IN
cord-001835-0s7ok4uw	4469	50	metabolites	metabolite	NNS
cord-001835-0s7ok4uw	4469	51	which	which	WDT
cord-001835-0s7ok4uw	4469	52	are	be	VBP
cord-001835-0s7ok4uw	4469	53	ultimately	ultimately	RB
cord-001835-0s7ok4uw	4469	54	responsible	responsible	JJ
cord-001835-0s7ok4uw	4469	55	for	for	IN
cord-001835-0s7ok4uw	4469	56	wine	wine	NN
cord-001835-0s7ok4uw	4469	57	quality	quality	NN
cord-001835-0s7ok4uw	4469	58	.	.	.
cord-001835-0s7ok4uw	4470	1	By	by	IN
cord-001835-0s7ok4uw	4470	2	using	use	VBG
cord-001835-0s7ok4uw	4470	3	novel	novel	JJ
cord-001835-0s7ok4uw	4470	4	proteomic	proteomic	NN
cord-001835-0s7ok4uw	4470	5	(	(	-LRB-
cord-001835-0s7ok4uw	4470	6	OFFGEL	OFFGEL	NNP
cord-001835-0s7ok4uw	4470	7	fractionator	fractionator	NN
cord-001835-0s7ok4uw	4470	8	and	and	CC
cord-001835-0s7ok4uw	4470	9	LTQ	LTQ	NNP
cord-001835-0s7ok4uw	4470	10	Orbitrap	Orbitrap	NNP
cord-001835-0s7ok4uw	4470	11	XL	XL	NNP
cord-001835-0s7ok4uw	4470	12	MS	MS	NNP
cord-001835-0s7ok4uw	4470	13	)	)	-RRB-
cord-001835-0s7ok4uw	4470	14	and	and	CC
cord-001835-0s7ok4uw	4470	15	metabolomic	metabolomic	JJ
cord-001835-0s7ok4uw	4470	16	techniques	technique	NNS
cord-001835-0s7ok4uw	4470	17	(	(	-LRB-
cord-001835-0s7ok4uw	4470	18	SBSE	SBSE	NNP
cord-001835-0s7ok4uw	4470	19	-	-	HYPH
cord-001835-0s7ok4uw	4470	20	TD	TD	NNP
cord-001835-0s7ok4uw	4470	21	-	-	HYPH
cord-001835-0s7ok4uw	4470	22	GC	GC	NNP
cord-001835-0s7ok4uw	4470	23	-	-	HYPH
cord-001835-0s7ok4uw	4470	24	MS	MS	NNP
cord-001835-0s7ok4uw	4470	25	)	)	-RRB-
cord-001835-0s7ok4uw	4470	26	we	-PRON-	PRP
cord-001835-0s7ok4uw	4470	27	have	have	VBP
cord-001835-0s7ok4uw	4470	28	identified	identify	VBN
cord-001835-0s7ok4uw	4470	29	a	a	DT
cord-001835-0s7ok4uw	4470	30	high	high	JJ
cord-001835-0s7ok4uw	4470	31	amount	amount	NN
cord-001835-0s7ok4uw	4470	32	of	of	IN
cord-001835-0s7ok4uw	4470	33	up	up	RB
cord-001835-0s7ok4uw	4470	34	-	-	HYPH
cord-001835-0s7ok4uw	4470	35	regulated	regulate	VBN
cord-001835-0s7ok4uw	4470	36	proteins	protein	NNS
cord-001835-0s7ok4uw	4470	37	involved	involve	VBN
cord-001835-0s7ok4uw	4470	38	in	in	IN
cord-001835-0s7ok4uw	4470	39	processes	process	NNS
cord-001835-0s7ok4uw	4470	40	like	like	IN
cord-001835-0s7ok4uw	4470	41	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	4470	42	stress	stress	NN
cord-001835-0s7ok4uw	4470	43	response	response	NN
cord-001835-0s7ok4uw	4470	44	(	(	-LRB-
cord-001835-0s7ok4uw	4470	45	in	in	IN
cord-001835-0s7ok4uw	4470	46	biological	biological	JJ
cord-001835-0s7ok4uw	4470	47	aging	aging	NN
cord-001835-0s7ok4uw	4470	48	)	)	-RRB-
cord-001835-0s7ok4uw	4470	49	or	or	CC
cord-001835-0s7ok4uw	4470	50	protein	protein	NN
cord-001835-0s7ok4uw	4470	51	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	4470	52	(	(	-LRB-
cord-001835-0s7ok4uw	4470	53	in	in	IN
cord-001835-0s7ok4uw	4470	54	second	second	JJ
cord-001835-0s7ok4uw	4470	55	fermentation	fermentation	NN
cord-001835-0s7ok4uw	4470	56	)	)	-RRB-
cord-001835-0s7ok4uw	4470	57	as	as	RB
cord-001835-0s7ok4uw	4470	58	well	well	RB
cord-001835-0s7ok4uw	4470	59	as	as	IN
cord-001835-0s7ok4uw	4470	60	thirty	thirty	CD
cord-001835-0s7ok4uw	4470	61	-	-	HYPH
cord-001835-0s7ok4uw	4470	62	three	three	CD
cord-001835-0s7ok4uw	4470	63	proteins	protein	NNS
cord-001835-0s7ok4uw	4470	64	directly	directly	RB
cord-001835-0s7ok4uw	4470	65	involved	involve	VBN
cord-001835-0s7ok4uw	4470	66	in	in	IN
cord-001835-0s7ok4uw	4470	67	the	the	DT
cord-001835-0s7ok4uw	4470	68	metabolism	metabolism	NN
cord-001835-0s7ok4uw	4470	69	of	of	IN
cord-001835-0s7ok4uw	4470	70	glycerol	glycerol	NN
cord-001835-0s7ok4uw	4470	71	,	,	,
cord-001835-0s7ok4uw	4470	72	ethanol	ethanol	NN
cord-001835-0s7ok4uw	4470	73	and	and	CC
cord-001835-0s7ok4uw	4470	74	seventeen	seventeen	CD
cord-001835-0s7ok4uw	4470	75	aroma	aroma	NN
cord-001835-0s7ok4uw	4470	76	compounds	compound	NNS
cord-001835-0s7ok4uw	4470	77	excreted	excrete	VBN
cord-001835-0s7ok4uw	4470	78	by	by	IN
cord-001835-0s7ok4uw	4470	79	the	the	DT
cord-001835-0s7ok4uw	4470	80	yeast	yeast	NN
cord-001835-0s7ok4uw	4470	81	under	under	IN
cord-001835-0s7ok4uw	4470	82	biological	biological	JJ
cord-001835-0s7ok4uw	4470	83	aging	aging	NN
cord-001835-0s7ok4uw	4470	84	conditions	condition	NNS
cord-001835-0s7ok4uw	4470	85	.	.	.
cord-001835-0s7ok4uw	4471	1	Further	further	RB
cord-001835-0s7ok4uw	4471	2	,	,	,
cord-001835-0s7ok4uw	4471	3	in	in	IN
cord-001835-0s7ok4uw	4471	4	order	order	NN
cord-001835-0s7ok4uw	4471	5	to	to	TO
cord-001835-0s7ok4uw	4471	6	validate	validate	VB
cord-001835-0s7ok4uw	4471	7	proteome	proteome	NN
cord-001835-0s7ok4uw	4471	8	data	datum	NNS
cord-001835-0s7ok4uw	4471	9	;	;	:
cord-001835-0s7ok4uw	4471	10	null	null	JJ
cord-001835-0s7ok4uw	4471	11	mutants	mutant	NNS
cord-001835-0s7ok4uw	4471	12	of	of	IN
cord-001835-0s7ok4uw	4471	13	genes	gene	NNS
cord-001835-0s7ok4uw	4471	14	codifying	codify	VBG
cord-001835-0s7ok4uw	4471	15	proteins	protein	NNS
cord-001835-0s7ok4uw	4471	16	up	up	RB
cord-001835-0s7ok4uw	4471	17	-	-	HYPH
cord-001835-0s7ok4uw	4471	18	regulated	regulate	VBN
cord-001835-0s7ok4uw	4471	19	in	in	IN
cord-001835-0s7ok4uw	4471	20	the	the	DT
cord-001835-0s7ok4uw	4471	21	biological	biological	JJ
cord-001835-0s7ok4uw	4471	22	aging	age	VBG
cord-001835-0s7ok4uw	4471	23	condition	condition	NN
cord-001835-0s7ok4uw	4471	24	were	be	VBD
cord-001835-0s7ok4uw	4471	25	constructed	construct	VBN
cord-001835-0s7ok4uw	4471	26	.	.	.
cord-001835-0s7ok4uw	4472	1	Analyses	analysis	NNS
cord-001835-0s7ok4uw	4472	2	of	of	IN
cord-001835-0s7ok4uw	4472	3	correlated	correlate	VBN
cord-001835-0s7ok4uw	4472	4	phenotypes	phenotype	NNS
cord-001835-0s7ok4uw	4472	5	are	be	VBP
cord-001835-0s7ok4uw	4472	6	in	in	IN
cord-001835-0s7ok4uw	4472	7	progress	progress	NN
cord-001835-0s7ok4uw	4472	8	.	.	.
cord-001835-0s7ok4uw	4473	1	This	this	DT
cord-001835-0s7ok4uw	4473	2	technique	technique	NN
cord-001835-0s7ok4uw	4473	3	and	and	CC
cord-001835-0s7ok4uw	4473	4	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4473	5	combination	combination	NN
cord-001835-0s7ok4uw	4473	6	with	with	IN
cord-001835-0s7ok4uw	4473	7	Metabolomics	Metabolomics	NNPS
cord-001835-0s7ok4uw	4473	8	within	within	IN
cord-001835-0s7ok4uw	4473	9	the	the	DT
cord-001835-0s7ok4uw	4473	10	enology	enology	NN
cord-001835-0s7ok4uw	4473	11	context	context	NN
cord-001835-0s7ok4uw	4473	12	will	will	MD
cord-001835-0s7ok4uw	4473	13	provide	provide	VB
cord-001835-0s7ok4uw	4473	14	enough	enough	JJ
cord-001835-0s7ok4uw	4473	15	knowledge	knowledge	NN
cord-001835-0s7ok4uw	4473	16	to	to	TO
cord-001835-0s7ok4uw	4473	17	design	design	VB
cord-001835-0s7ok4uw	4473	18	or	or	CC
cord-001835-0s7ok4uw	4473	19	choose	choose	VB
cord-001835-0s7ok4uw	4473	20	yeasts	yeast	NNS
cord-001835-0s7ok4uw	4473	21	or	or	CC
cord-001835-0s7ok4uw	4473	22	conditions	condition	NNS
cord-001835-0s7ok4uw	4473	23	that	that	WDT
cord-001835-0s7ok4uw	4473	24	satisfy	satisfy	VBP
cord-001835-0s7ok4uw	4473	25	wine	wine	NN
cord-001835-0s7ok4uw	4473	26	production	production	NN
cord-001835-0s7ok4uw	4473	27	and/or	and/or	CC
cord-001835-0s7ok4uw	4473	28	wine	wine	NN
cord-001835-0s7ok4uw	4473	29	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	4473	30	such	such	JJ
cord-001835-0s7ok4uw	4473	31	as	as	IN
cord-001835-0s7ok4uw	4473	32	color	color	NN
cord-001835-0s7ok4uw	4473	33	/	/	SYM
cord-001835-0s7ok4uw	4473	34	aroma	aroma	NN
cord-001835-0s7ok4uw	4473	35	/	/	SYM
cord-001835-0s7ok4uw	4473	36	texture	texture	NN
cord-001835-0s7ok4uw	4473	37	/	/	SYM
cord-001835-0s7ok4uw	4473	38	flavour	flavour	NN
cord-001835-0s7ok4uw	4473	39	profile	profile	NN
cord-001835-0s7ok4uw	4473	40	demands	demand	NNS
cord-001835-0s7ok4uw	4473	41	of	of	IN
cord-001835-0s7ok4uw	4473	42	winemakers	winemaker	NNS
cord-001835-0s7ok4uw	4473	43	and	and	CC
cord-001835-0s7ok4uw	4473	44	consumers	consumer	NNS
cord-001835-0s7ok4uw	4473	45	.	.	.
cord-001835-0s7ok4uw	4474	1	Additional	additional	JJ
cord-001835-0s7ok4uw	4474	2	binding	bind	VBG
cord-001835-0s7ok4uw	4474	3	sites	site	NNS
cord-001835-0s7ok4uw	4474	4	for	for	IN
cord-001835-0s7ok4uw	4474	5	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	4474	6	c	c	NN
cord-001835-0s7ok4uw	4474	7	on	on	IN
cord-001835-0s7ok4uw	4474	8	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4474	9	redox	redox	NN
cord-001835-0s7ok4uw	4474	10	membrane	membrane	NN
cord-001835-0s7ok4uw	4474	11	partners	partner	NNS
cord-001835-0s7ok4uw	4474	12	facilitate	facilitate	VBP
cord-001835-0s7ok4uw	4474	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4474	14	turnover	turnover	NN
cord-001835-0s7ok4uw	4474	15	and	and	CC
cord-001835-0s7ok4uw	4474	16	sliding	sliding	NN
cord-001835-0s7ok4uw	4474	17	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4474	18	within	within	IN
cord-001835-0s7ok4uw	4474	19	respiratory	respiratory	JJ
cord-001835-0s7ok4uw	4474	20	supercomplexes	supercomplexes	NN
cord-001835-0s7ok4uw	4474	21	Blas	Blas	NNP
cord-001835-0s7ok4uw	4474	22	Moreno	Moreno	NNP
cord-001835-0s7ok4uw	4474	23	-	-	HYPH
cord-001835-0s7ok4uw	4474	24	Beltr	Beltr	NNP
cord-001835-0s7ok4uw	4474	25	an	an	DT
cord-001835-0s7ok4uw	4474	26	1	1	CD
cord-001835-0s7ok4uw	4474	27	,	,	,
cord-001835-0s7ok4uw	4474	28	Antonio	Antonio	NNP
cord-001835-0s7ok4uw	4474	29	D	D	NNP
cord-001835-0s7ok4uw	4474	30	ıaz	ıaz	NNP
cord-001835-0s7ok4uw	4474	31	-	-	HYPH
cord-001835-0s7ok4uw	4474	32	Quintana	Quintana	NNP
cord-001835-0s7ok4uw	4474	33	1	1	CD
cord-001835-0s7ok4uw	4474	34	,	,	,
cord-001835-0s7ok4uw	4474	35	Katiuska	Katiuska	NNP
cord-001835-0s7ok4uw	4474	36	Gonz	Gonz	NNP
cord-001835-0s7ok4uw	4474	37	alez	alez	NNP
cord-001835-0s7ok4uw	4474	38	-	-	HYPH
cord-001835-0s7ok4uw	4474	39	Arzola	Arzola	NNP
cord-001835-0s7ok4uw	4474	40	1	1	CD
cord-001835-0s7ok4uw	4474	41	,	,	,
cord-001835-0s7ok4uw	4474	42	Alejandra	Alejandra	NNP
cord-001835-0s7ok4uw	4474	43	Guerra	Guerra	NNP
cord-001835-0s7ok4uw	4474	44	-	-	HYPH
cord-001835-0s7ok4uw	4474	45	Castellano	Castellano	NNP
cord-001835-0s7ok4uw	4474	46	1	1	CD
cord-001835-0s7ok4uw	4474	47	,	,	,
cord-001835-0s7ok4uw	4474	48	Adri	Adri	NNP
cord-001835-0s7ok4uw	4474	49	an	an	DT
cord-001835-0s7ok4uw	4474	50	Vel	Vel	NNP
cord-001835-0s7ok4uw	4474	51	azquez	azquez	NNP
cord-001835-0s7ok4uw	4474	52	-	-	HYPH
cord-001835-0s7ok4uw	4474	53	Campoy	Campoy	NNP
cord-001835-0s7ok4uw	4474	54	0	0	CD
cord-001835-0s7ok4uw	4474	55	,	,	,
cord-001835-0s7ok4uw	4474	56	Miguel	Miguel	NNP
cord-001835-0s7ok4uw	4474	57	A.	a.	NN
cord-001835-0s7ok4uw	4474	58	De	De	NNP
cord-001835-0s7ok4uw	4474	59	la	la	NNP
cord-001835-0s7ok4uw	4474	60	Rosa	Rosa	NNP
cord-001835-0s7ok4uw	4474	61	1	1	CD
cord-001835-0s7ok4uw	4474	62	,	,	,
cord-001835-0s7ok4uw	4474	63	Irene	Irene	NNP
cord-001835-0s7ok4uw	4474	64	D	D	NNP
cord-001835-0s7ok4uw	4474	65	ıaz	ıaz	NNP
cord-001835-0s7ok4uw	4474	66	-	-	HYPH
cord-001835-0s7ok4uw	4474	67	Moreno	Moreno	NNP
cord-001835-0s7ok4uw	4474	68	1	1	CD
cord-001835-0s7ok4uw	4474	69	1	1	CD
cord-001835-0s7ok4uw	4474	70	IBVF	IBVF	NNP
cord-001835-0s7ok4uw	4474	71	,	,	,
cord-001835-0s7ok4uw	4474	72	cicCartuja	ciccartuja	FW
cord-001835-0s7ok4uw	4474	73	,	,	,
cord-001835-0s7ok4uw	4474	74	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	4474	75	de	de	NNP
cord-001835-0s7ok4uw	4474	76	Sevilla	Sevilla	NNP
cord-001835-0s7ok4uw	4474	77	-CSIC	-CSIC	NNP
cord-001835-0s7ok4uw	4474	78	,	,	,
cord-001835-0s7ok4uw	4474	79	2	2	CD
cord-001835-0s7ok4uw	4474	80	BIFI	BIFI	NNP
cord-001835-0s7ok4uw	4474	81	-IQFR	-IQFR	.
cord-001835-0s7ok4uw	4475	1	(	(	-LRB-
cord-001835-0s7ok4uw	4475	2	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	4475	3	)	)	-RRB-
cord-001835-0s7ok4uw	4475	4	,	,	,
cord-001835-0s7ok4uw	4475	5	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	4475	6	de	de	NNP
cord-001835-0s7ok4uw	4475	7	Zaragoza	Zaragoza	NNP
cord-001835-0s7ok4uw	4475	8	,	,	,
cord-001835-0s7ok4uw	4475	9	3	3	CD
cord-001835-0s7ok4uw	4475	10	Departamento	Departamento	NNP
cord-001835-0s7ok4uw	4475	11	de	de	NNP
cord-001835-0s7ok4uw	4475	12	Bioqu	Bioqu	NNP
cord-001835-0s7ok4uw	4475	13	ımica	ımica	NNP
cord-001835-0s7ok4uw	4476	1	y	y	NNP
cord-001835-0s7ok4uw	4476	2	Biolog	Biolog	NNP
cord-001835-0s7ok4uw	4476	3	ıa	ıa	VBZ
cord-001835-0s7ok4uw	4476	4	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	4476	5	Celular	Celular	NNP
cord-001835-0s7ok4uw	4476	6	,	,	,
cord-001835-0s7ok4uw	4476	7	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	4476	8	de	de	NNP
cord-001835-0s7ok4uw	4476	9	Zaragoza	Zaragoza	NNP
cord-001835-0s7ok4uw	4476	10	,	,	,
cord-001835-0s7ok4uw	4476	11	4	4	CD
cord-001835-0s7ok4uw	4476	12	 	 	_SP
cord-001835-0s7ok4uw	4476	13	Gliding	gliding	NN
cord-001835-0s7ok4uw	4476	14	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4476	15	of	of	IN
cord-001835-0s7ok4uw	4476	16	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	4476	17	c	c	NN
cord-001835-0s7ok4uw	4476	18	(	(	-LRB-
cord-001835-0s7ok4uw	4476	19	Cc	cc	NN
cord-001835-0s7ok4uw	4476	20	)	)	-RRB-
cord-001835-0s7ok4uw	4476	21	molecules	molecule	NNS
cord-001835-0s7ok4uw	4476	22	have	have	VBP
cord-001835-0s7ok4uw	4476	23	been	be	VBN
cord-001835-0s7ok4uw	4476	24	proposed	propose	VBN
cord-001835-0s7ok4uw	4476	25	to	to	IN
cord-001835-0s7ok4uw	4476	26	shuttle	shuttle	NN
cord-001835-0s7ok4uw	4476	27	electrons	electron	NNS
cord-001835-0s7ok4uw	4476	28	between	between	IN
cord-001835-0s7ok4uw	4476	29	respiratory	respiratory	JJ
cord-001835-0s7ok4uw	4476	30	complexes	complex	NNS
cord-001835-0s7ok4uw	4476	31	III	III	NNP
cord-001835-0s7ok4uw	4476	32	and	and	CC
cord-001835-0s7ok4uw	4476	33	IV	IV	NNP
cord-001835-0s7ok4uw	4476	34	within	within	IN
cord-001835-0s7ok4uw	4476	35	plant	plant	NN
cord-001835-0s7ok4uw	4476	36	and	and	CC
cord-001835-0s7ok4uw	4476	37	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	4476	38	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	4476	39	supercomplexes	supercomplexe	NNS
cord-001835-0s7ok4uw	4476	40	,	,	,
cord-001835-0s7ok4uw	4476	41	instead	instead	RB
cord-001835-0s7ok4uw	4476	42	of	of	IN
cord-001835-0s7ok4uw	4476	43	carrying	carry	VBG
cord-001835-0s7ok4uw	4476	44	electrons	electron	NNS
cord-001835-0s7ok4uw	4476	45	by	by	IN
cord-001835-0s7ok4uw	4476	46	random	random	JJ
cord-001835-0s7ok4uw	4476	47	diffusion	diffusion	NN
cord-001835-0s7ok4uw	4476	48	across	across	IN
cord-001835-0s7ok4uw	4476	49	the	the	DT
cord-001835-0s7ok4uw	4476	50	intermembrane	intermembrane	NNP
cord-001835-0s7ok4uw	4476	51	bulk	bulk	NN
cord-001835-0s7ok4uw	4476	52	phase	phase	NN
cord-001835-0s7ok4uw	4476	53	[	[	-LRB-
cord-001835-0s7ok4uw	4476	54	1	1	CD
cord-001835-0s7ok4uw	4476	55	]	]	-RRB-
cord-001835-0s7ok4uw	4476	56	[	[	-LRB-
cord-001835-0s7ok4uw	4476	57	2	2	CD
cord-001835-0s7ok4uw	4476	58	]	]	-RRB-
cord-001835-0s7ok4uw	4476	59	.	.	.
cord-001835-0s7ok4uw	4477	1	In	in	IN
cord-001835-0s7ok4uw	4477	2	this	this	DT
cord-001835-0s7ok4uw	4477	3	work	work	NN
cord-001835-0s7ok4uw	4477	4	,	,	,
cord-001835-0s7ok4uw	4477	5	the	the	DT
cord-001835-0s7ok4uw	4477	6	binding	bind	VBG
cord-001835-0s7ok4uw	4477	7	molecular	molecular	JJ
cord-001835-0s7ok4uw	4477	8	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4477	9	of	of	IN
cord-001835-0s7ok4uw	4477	10	the	the	DT
cord-001835-0s7ok4uw	4477	11	plant	plant	NN
cord-001835-0s7ok4uw	4477	12	and	and	CC
cord-001835-0s7ok4uw	4477	13	human	human	NN
cord-001835-0s7ok4uw	4477	14	Cc	Cc	NNP
cord-001835-0s7ok4uw	4477	15	with	with	IN
cord-001835-0s7ok4uw	4477	16	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	4477	17	complexes	complex	NNS
cord-001835-0s7ok4uw	4477	18	III	III	NNP
cord-001835-0s7ok4uw	4477	19	and	and	CC
cord-001835-0s7ok4uw	4477	20	IV	IV	NNP
cord-001835-0s7ok4uw	4477	21	have	have	VBP
cord-001835-0s7ok4uw	4477	22	been	be	VBN
cord-001835-0s7ok4uw	4477	23	analyzed	analyze	VBN
cord-001835-0s7ok4uw	4477	24	by	by	IN
cord-001835-0s7ok4uw	4477	25	Nuclear	Nuclear	NNP
cord-001835-0s7ok4uw	4477	26	Magnetic	Magnetic	NNP
cord-001835-0s7ok4uw	4477	27	Resonance	Resonance	NNP
cord-001835-0s7ok4uw	4477	28	and	and	CC
cord-001835-0s7ok4uw	4477	29	Isothermal	Isothermal	NNP
cord-001835-0s7ok4uw	4477	30	Titration	Titration	NNP
cord-001835-0s7ok4uw	4477	31	Calorimetry	Calorimetry	NNP
cord-001835-0s7ok4uw	4477	32	.	.	.
cord-001835-0s7ok4uw	4478	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4478	2	data	datum	NNS
cord-001835-0s7ok4uw	4478	3	reveal	reveal	VBP
cord-001835-0s7ok4uw	4478	4	that	that	IN
cord-001835-0s7ok4uw	4478	5	both	both	DT
cord-001835-0s7ok4uw	4478	6	Cc	cc	NN
cord-001835-0s7ok4uw	4478	7	-	-	HYPH
cord-001835-0s7ok4uw	4478	8	involving	involve	VBG
cord-001835-0s7ok4uw	4478	9	adducts	adduct	NNS
cord-001835-0s7ok4uw	4478	10	possess	possess	VBP
cord-001835-0s7ok4uw	4478	11	a	a	DT
cord-001835-0s7ok4uw	4478	12	2:1	2:1	CD
cord-001835-0s7ok4uw	4478	13	stoichiometry	stoichiometry	NN
cord-001835-0s7ok4uw	4478	14	-that	-that	NN
cord-001835-0s7ok4uw	4478	15	is	be	VBZ
cord-001835-0s7ok4uw	4479	1	,	,	,
cord-001835-0s7ok4uw	4479	2	two	two	CD
cord-001835-0s7ok4uw	4479	3	Cc	cc	NN
cord-001835-0s7ok4uw	4479	4	molecules	molecule	NNS
cord-001835-0s7ok4uw	4479	5	per	per	IN
cord-001835-0s7ok4uw	4479	6	adduct	adduct	NN
cord-001835-0s7ok4uw	4479	7	-	-	HYPH
cord-001835-0s7ok4uw	4479	8	.	.	.
cord-001835-0s7ok4uw	4480	1	The	the	DT
cord-001835-0s7ok4uw	4480	2	presence	presence	NN
cord-001835-0s7ok4uw	4480	3	of	of	IN
cord-001835-0s7ok4uw	4480	4	extra	extra	JJ
cord-001835-0s7ok4uw	4480	5	binding	binding	JJ
cord-001835-0s7ok4uw	4480	6	sites	site	NNS
cord-001835-0s7ok4uw	4480	7	for	for	IN
cord-001835-0s7ok4uw	4480	8	Cc	cc	NN
cord-001835-0s7ok4uw	4480	9	at	at	IN
cord-001835-0s7ok4uw	4480	10	the	the	DT
cord-001835-0s7ok4uw	4480	11	surfaces	surface	NNS
cord-001835-0s7ok4uw	4480	12	of	of	IN
cord-001835-0s7ok4uw	4480	13	complexes	complex	NNS
cord-001835-0s7ok4uw	4480	14	III	III	NNP
cord-001835-0s7ok4uw	4480	15	and	and	CC
cord-001835-0s7ok4uw	4480	16	IV	IV	NNP
cord-001835-0s7ok4uw	4480	17	opens	open	VBZ
cord-001835-0s7ok4uw	4480	18	new	new	JJ
cord-001835-0s7ok4uw	4480	19	perspectives	perspective	NNS
cord-001835-0s7ok4uw	4480	20	on	on	IN
cord-001835-0s7ok4uw	4480	21	the	the	DT
cord-001835-0s7ok4uw	4480	22	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	4480	23	electron	electron	NN
cord-001835-0s7ok4uw	4480	24	transport	transport	NN
cord-001835-0s7ok4uw	4480	25	chain	chain	NN
cord-001835-0s7ok4uw	4480	26	,	,	,
cord-001835-0s7ok4uw	4480	27	where	where	WRB
cord-001835-0s7ok4uw	4480	28	membrane	membrane	NN
cord-001835-0s7ok4uw	4480	29	respiratory	respiratory	JJ
cord-001835-0s7ok4uw	4480	30	complexes	complex	NNS
cord-001835-0s7ok4uw	4480	31	can	can	MD
cord-001835-0s7ok4uw	4480	32	be	be	VB
cord-001835-0s7ok4uw	4480	33	either	either	CC
cord-001835-0s7ok4uw	4480	34	in	in	IN
cord-001835-0s7ok4uw	4480	35	independent	independent	JJ
cord-001835-0s7ok4uw	4480	36	,	,	,
cord-001835-0s7ok4uw	4480	37	free	free	JJ
cord-001835-0s7ok4uw	4480	38	diffusional	diffusional	JJ
cord-001835-0s7ok4uw	4480	39	motion	motion	NN
cord-001835-0s7ok4uw	4480	40	or	or	CC
cord-001835-0s7ok4uw	4480	41	forming	form	VBG
cord-001835-0s7ok4uw	4480	42	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	4480	43	assemblies	assembly	NNS
cord-001835-0s7ok4uw	4480	44	.	.	.
cord-001835-0s7ok4uw	4481	1	In	in	IN
cord-001835-0s7ok4uw	4481	2	the	the	DT
cord-001835-0s7ok4uw	4481	3	latter	latter	JJ
cord-001835-0s7ok4uw	4481	4	context	context	NN
cord-001835-0s7ok4uw	4481	5	,	,	,
cord-001835-0s7ok4uw	4481	6	such	such	JJ
cord-001835-0s7ok4uw	4481	7	new	new	JJ
cord-001835-0s7ok4uw	4481	8	binding	bind	VBG
cord-001835-0s7ok4uw	4481	9	sites	site	NNS
cord-001835-0s7ok4uw	4481	10	for	for	IN
cord-001835-0s7ok4uw	4481	11	Cc	Cc	NNP
cord-001835-0s7ok4uw	4481	12	facilitate	facilitate	VBP
cord-001835-0s7ok4uw	4481	13	the	the	DT
cord-001835-0s7ok4uw	4481	14	turnover	turnover	NN
cord-001835-0s7ok4uw	4481	15	and	and	CC
cord-001835-0s7ok4uw	4481	16	sliding	sliding	NN
cord-001835-0s7ok4uw	4481	17	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4481	18	of	of	IN
cord-001835-0s7ok4uw	4481	19	Cc	Cc	NNP
cord-001835-0s7ok4uw	4481	20	molecules	molecule	NNS
cord-001835-0s7ok4uw	4481	21	within	within	IN
cord-001835-0s7ok4uw	4481	22	supercomplexes	supercomplexes	NNP
cord-001835-0s7ok4uw	4481	23	.	.	.
cord-001835-0s7ok4uw	4482	1	Indeed	indeed	RB
cord-001835-0s7ok4uw	4482	2	,	,	,
cord-001835-0s7ok4uw	4482	3	the	the	DT
cord-001835-0s7ok4uw	4482	4	accommodation	accommodation	NN
cord-001835-0s7ok4uw	4482	5	of	of	IN
cord-001835-0s7ok4uw	4482	6	several	several	JJ
cord-001835-0s7ok4uw	4482	7	Cc	Cc	NNP
cord-001835-0s7ok4uw	4482	8	molecules	molecule	NNS
cord-001835-0s7ok4uw	4482	9	between	between	IN
cord-001835-0s7ok4uw	4482	10	complexes	complex	NNS
cord-001835-0s7ok4uw	4482	11	III	III	NNP
cord-001835-0s7ok4uw	4482	12	and	and	CC
cord-001835-0s7ok4uw	4482	13	IV	IV	NNP
cord-001835-0s7ok4uw	4482	14	in	in	IN
cord-001835-0s7ok4uw	4482	15	supercomplexes	supercomplexes	NNP
cord-001835-0s7ok4uw	4482	16	provide	provide	VBP
cord-001835-0s7ok4uw	4482	17	a	a	DT
cord-001835-0s7ok4uw	4482	18	path	path	NN
cord-001835-0s7ok4uw	4482	19	for	for	IN
cord-001835-0s7ok4uw	4482	20	Cc	Cc	NNP
cord-001835-0s7ok4uw	4482	21	diffusion	diffusion	NN
cord-001835-0s7ok4uw	4482	22	from	from	IN
cord-001835-0s7ok4uw	4482	23	complex	complex	JJ
cord-001835-0s7ok4uw	4482	24	III	III	NNP
cord-001835-0s7ok4uw	4482	25	to	to	IN
cord-001835-0s7ok4uw	4482	26	IV	IV	NNP
cord-001835-0s7ok4uw	4482	27	.	.	.
cord-001835-0s7ok4uw	4483	1	Such	such	JJ
cord-001835-0s7ok4uw	4483	2	path	path	NN
cord-001835-0s7ok4uw	4483	3	could	could	MD
cord-001835-0s7ok4uw	4483	4	have	have	VB
cord-001835-0s7ok4uw	4483	5	physiological	physiological	JJ
cord-001835-0s7ok4uw	4483	6	significance	significance	NN
cord-001835-0s7ok4uw	4483	7	in	in	IN
cord-001835-0s7ok4uw	4483	8	the	the	DT
cord-001835-0s7ok4uw	4483	9	electron	electron	NN
cord-001835-0s7ok4uw	4483	10	flow	flow	NN
cord-001835-0s7ok4uw	4483	11	,	,	,
cord-001835-0s7ok4uw	4483	12	which	which	WDT
cord-001835-0s7ok4uw	4483	13	is	be	VBZ
cord-001835-0s7ok4uw	4483	14	controlled	control	VBN
cord-001835-0s7ok4uw	4483	15	in	in	IN
cord-001835-0s7ok4uw	4483	16	supercomplexes	supercomplexes	NNP
cord-001835-0s7ok4uw	4483	17	to	to	TO
cord-001835-0s7ok4uw	4483	18	optimize	optimize	VB
cord-001835-0s7ok4uw	4483	19	the	the	DT
cord-001835-0s7ok4uw	4483	20	use	use	NN
cord-001835-0s7ok4uw	4483	21	of	of	IN
cord-001835-0s7ok4uw	4483	22	available	available	JJ
cord-001835-0s7ok4uw	4483	23	substrates	substrate	NNS
cord-001835-0s7ok4uw	4483	24	[	[	-LRB-
cord-001835-0s7ok4uw	4483	25	3	3	CD
cord-001835-0s7ok4uw	4483	26	]	]	-RRB-
cord-001835-0s7ok4uw	4483	27	[	[	-LRB-
cord-001835-0s7ok4uw	4483	28	4	4	CD
cord-001835-0s7ok4uw	4483	29	]	]	-RRB-
cord-001835-0s7ok4uw	4483	30	[	[	-LRB-
cord-001835-0s7ok4uw	4483	31	5	5	CD
cord-001835-0s7ok4uw	4483	32	]	]	-RRB-
cord-001835-0s7ok4uw	4483	33	.	.	.
cord-001835-0s7ok4uw	4483	34	 	 	_SP
cord-001835-0s7ok4uw	4484	1	Can	Can	MD
cord-001835-0s7ok4uw	4484	2	Bio	Bio	NNP
cord-001835-0s7ok4uw	4484	3	-	-	HYPH
cord-001835-0s7ok4uw	4484	4	functionalities	functionality	NNS
cord-001835-0s7ok4uw	4484	5	be	be	VB
cord-001835-0s7ok4uw	4484	6	deciphered	decipher	VBN
cord-001835-0s7ok4uw	4484	7	from	from	IN
cord-001835-0s7ok4uw	4484	8	protein	protein	NN
cord-001835-0s7ok4uw	4484	9	sequence	sequence	NN
cord-001835-0s7ok4uw	4484	10	information	information	NN
cord-001835-0s7ok4uw	4484	11	using	use	VBG
cord-001835-0s7ok4uw	4484	12	computational	computational	JJ
cord-001835-0s7ok4uw	4484	13	approaches	approach	NNS
cord-001835-0s7ok4uw	4484	14	?	?	.
cord-001835-0s7ok4uw	4485	1	Background	background	NN
cord-001835-0s7ok4uw	4485	2	:	:	:
cord-001835-0s7ok4uw	4486	1	The	the	DT
cord-001835-0s7ok4uw	4486	2	processes	process	NNS
cord-001835-0s7ok4uw	4486	3	of	of	IN
cord-001835-0s7ok4uw	4486	4	uncovering	uncover	VBG
cord-001835-0s7ok4uw	4486	5	bio	bio	NN
cord-001835-0s7ok4uw	4486	6	-	-	HYPH
cord-001835-0s7ok4uw	4486	7	functionalities	functionality	NNS
cord-001835-0s7ok4uw	4486	8	such	such	JJ
cord-001835-0s7ok4uw	4486	9	as	as	IN
cord-001835-0s7ok4uw	4486	10	pharmacological	pharmacological	JJ
cord-001835-0s7ok4uw	4486	11	activities	activity	NNS
cord-001835-0s7ok4uw	4486	12	,	,	,
cord-001835-0s7ok4uw	4486	13	disease	disease	NN
cord-001835-0s7ok4uw	4486	14	processes	process	NNS
cord-001835-0s7ok4uw	4486	15	,	,	,
cord-001835-0s7ok4uw	4486	16	physiological	physiological	JJ
cord-001835-0s7ok4uw	4486	17	and	and	CC
cord-001835-0s7ok4uw	4486	18	structural	structural	JJ
cord-001835-0s7ok4uw	4486	19	properties	property	NNS
cord-001835-0s7ok4uw	4486	20	by	by	IN
cord-001835-0s7ok4uw	4486	21	means	mean	NNS
cord-001835-0s7ok4uw	4486	22	of	of	IN
cord-001835-0s7ok4uw	4486	23	clinical	clinical	JJ
cord-001835-0s7ok4uw	4486	24	approaches	approach	NNS
cord-001835-0s7ok4uw	4486	25	are	be	VBP
cord-001835-0s7ok4uw	4486	26	irrational	irrational	JJ
cord-001835-0s7ok4uw	4486	27	.	.	.
cord-001835-0s7ok4uw	4487	1	This	this	DT
cord-001835-0s7ok4uw	4487	2	is	be	VBZ
cord-001835-0s7ok4uw	4487	3	because	because	IN
cord-001835-0s7ok4uw	4487	4	they	-PRON-	PRP
cord-001835-0s7ok4uw	4487	5	are	be	VBP
cord-001835-0s7ok4uw	4487	6	resource	resource	NN
cord-001835-0s7ok4uw	4487	7	and	and	CC
cord-001835-0s7ok4uw	4487	8	time	time	NN
cord-001835-0s7ok4uw	4487	9	consuming	consume	VBG
cord-001835-0s7ok4uw	4487	10	.	.	.
cord-001835-0s7ok4uw	4488	1	Sometimes	sometimes	RB
cord-001835-0s7ok4uw	4488	2	,	,	,
cord-001835-0s7ok4uw	4488	3	they	-PRON-	PRP
cord-001835-0s7ok4uw	4488	4	involve	involve	VBP
cord-001835-0s7ok4uw	4488	5	sophisticated	sophisticated	JJ
cord-001835-0s7ok4uw	4488	6	and	and	CC
cord-001835-0s7ok4uw	4488	7	expensive	expensive	JJ
cord-001835-0s7ok4uw	4488	8	equipments	equipment	NNS
cord-001835-0s7ok4uw	4488	9	,	,	,
cord-001835-0s7ok4uw	4488	10	reagents	reagent	NNS
cord-001835-0s7ok4uw	4488	11	and	and	CC
cord-001835-0s7ok4uw	4488	12	animal	animal	NN
cord-001835-0s7ok4uw	4488	13	tissues	tissue	NNS
cord-001835-0s7ok4uw	4488	14	.	.	.
cord-001835-0s7ok4uw	4489	1	Contrarily	contrarily	RB
cord-001835-0s7ok4uw	4489	2	,	,	,
cord-001835-0s7ok4uw	4489	3	sequence	sequence	NN
cord-001835-0s7ok4uw	4489	4	information	information	NN
cord-001835-0s7ok4uw	4489	5	-	-	HYPH
cord-001835-0s7ok4uw	4489	6	based	base	VBN
cord-001835-0s7ok4uw	4489	7	computerized	computerized	JJ
cord-001835-0s7ok4uw	4489	8	approaches	approach	NNS
cord-001835-0s7ok4uw	4489	9	are	be	VBP
cord-001835-0s7ok4uw	4489	10	rational	rational	JJ
cord-001835-0s7ok4uw	4489	11	and	and	CC
cord-001835-0s7ok4uw	4489	12	have	have	VBP
cord-001835-0s7ok4uw	4489	13	become	become	VBN
cord-001835-0s7ok4uw	4489	14	relevant	relevant	JJ
cord-001835-0s7ok4uw	4489	15	in	in	IN
cord-001835-0s7ok4uw	4489	16	assessing	assess	VBG
cord-001835-0s7ok4uw	4489	17	bio	bio	NN
cord-001835-0s7ok4uw	4489	18	-	-	HYPH
cord-001835-0s7ok4uw	4489	19	functionalities	functionality	NNS
cord-001835-0s7ok4uw	4489	20	.	.	.
cord-001835-0s7ok4uw	4490	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	4490	2	include	include	VBP
cord-001835-0s7ok4uw	4490	3	geno2pheno	geno2pheno	NNP
cord-001835-0s7ok4uw	4490	4	[	[	-LRB-
cord-001835-0s7ok4uw	4490	5	CORECEPTOR	CORECEPTOR	NNP
cord-001835-0s7ok4uw	4490	6	]	]	-RRB-
cord-001835-0s7ok4uw	4490	7	[	[	-LRB-
cord-001835-0s7ok4uw	4490	8	1	1	CD
cord-001835-0s7ok4uw	4490	9	]	]	-RRB-
cord-001835-0s7ok4uw	4490	10	,	,	,
cord-001835-0s7ok4uw	4490	11	Position	position	NN
cord-001835-0s7ok4uw	4490	12	-	-	HYPH
cord-001835-0s7ok4uw	4490	13	Specific	Specific	NNP
cord-001835-0s7ok4uw	4490	14	Scoring	Scoring	NNP
cord-001835-0s7ok4uw	4490	15	Matrix	Matrix	NNP
cord-001835-0s7ok4uw	4490	16	(	(	-LRB-
cord-001835-0s7ok4uw	4490	17	PSSMSI	PSSMSI	NNP
cord-001835-0s7ok4uw	4490	18	/	/	SYM
cord-001835-0s7ok4uw	4490	19	NSI	NSI	NNP
cord-001835-0s7ok4uw	4490	20	and	and	CC
cord-001835-0s7ok4uw	4490	21	PSSMCXCR4	PSSMCXCR4	NNP
cord-001835-0s7ok4uw	4490	22	/	/	SYM
cord-001835-0s7ok4uw	4490	23	CCR5	CCR5	NNP
cord-001835-0s7ok4uw	4490	24	)	)	-RRB-
cord-001835-0s7ok4uw	4490	25	[	[	-LRB-
cord-001835-0s7ok4uw	4490	26	2	2	CD
cord-001835-0s7ok4uw	4490	27	]	]	-RRB-
cord-001835-0s7ok4uw	4490	28	,	,	,
cord-001835-0s7ok4uw	4490	29	and	and	CC
cord-001835-0s7ok4uw	4490	30	Informational	Informational	NNP
cord-001835-0s7ok4uw	4490	31	Spectrum	Spectrum	NNP
cord-001835-0s7ok4uw	4490	32	Method	Method	NNP
cord-001835-0s7ok4uw	4490	33	(	(	-LRB-
cord-001835-0s7ok4uw	4490	34	ISM)-based	ism)-base	VBN
cord-001835-0s7ok4uw	4490	35	phylogenetic	phylogenetic	JJ
cord-001835-0s7ok4uw	4490	36	analysis	analysis	NN
cord-001835-0s7ok4uw	4491	1	(	(	-LRB-
cord-001835-0s7ok4uw	4491	2	ISTREE	ISTREE	NNP
cord-001835-0s7ok4uw	4491	3	)	)	-RRB-
cord-001835-0s7ok4uw	4492	1	[	[	-LRB-
cord-001835-0s7ok4uw	4492	2	3	3	CD
cord-001835-0s7ok4uw	4492	3	]	]	-RRB-
cord-001835-0s7ok4uw	4492	4	.	.	.
cord-001835-0s7ok4uw	4493	1	Aim	aim	VB
cord-001835-0s7ok4uw	4493	2	:	:	:
cord-001835-0s7ok4uw	4493	3	This	this	DT
cord-001835-0s7ok4uw	4493	4	presentation	presentation	NN
cord-001835-0s7ok4uw	4493	5	demonstrates	demonstrate	VBZ
cord-001835-0s7ok4uw	4493	6	how	how	WRB
cord-001835-0s7ok4uw	4493	7	bio	bio	NN
cord-001835-0s7ok4uw	4493	8	-	-	NNS
cord-001835-0s7ok4uw	4493	9	functionalities	functionality	NNS
cord-001835-0s7ok4uw	4493	10	could	could	MD
cord-001835-0s7ok4uw	4493	11	be	be	VB
cord-001835-0s7ok4uw	4493	12	deciphered	decipher	VBN
cord-001835-0s7ok4uw	4493	13	from	from	IN
cord-001835-0s7ok4uw	4493	14	sequence	sequence	NN
cord-001835-0s7ok4uw	4493	15	information	information	NN
cord-001835-0s7ok4uw	4493	16	using	use	VBG
cord-001835-0s7ok4uw	4493	17	computational	computational	JJ
cord-001835-0s7ok4uw	4493	18	approaches	approach	NNS
cord-001835-0s7ok4uw	4493	19	.	.	.
cord-001835-0s7ok4uw	4494	1	Method	method	NN
cord-001835-0s7ok4uw	4494	2	:	:	:
cord-001835-0s7ok4uw	4494	3	ISM	ism	NN
cord-001835-0s7ok4uw	4494	4	procedure	procedure	NN
cord-001835-0s7ok4uw	4494	5	and	and	CC
cord-001835-0s7ok4uw	4494	6	peptides	peptide	NNS
cord-001835-0s7ok4uw	4494	7	,	,	,
cord-001835-0s7ok4uw	4494	8	VIPMFSALS	VIPMFSALS	NNP
cord-001835-0s7ok4uw	4494	9	and	and	CC
cord-001835-0s7ok4uw	4494	10	CAPAGFAIL	CAPAGFAIL	NNP
cord-001835-0s7ok4uw	4494	11	are	be	VBP
cord-001835-0s7ok4uw	4494	12	engaged	engage	VBN
cord-001835-0s7ok4uw	4494	13	.	.	.
cord-001835-0s7ok4uw	4495	1	Results	result	NNS
cord-001835-0s7ok4uw	4495	2	:	:	:
cord-001835-0s7ok4uw	4496	1	Protein	protein	NN
cord-001835-0s7ok4uw	4496	2	sequences	sequence	NNS
cord-001835-0s7ok4uw	4496	3	of	of	IN
cord-001835-0s7ok4uw	4496	4	the	the	DT
cord-001835-0s7ok4uw	4496	5	peptides	peptide	NNS
cord-001835-0s7ok4uw	4496	6	are	be	VBP
cord-001835-0s7ok4uw	4496	7	converted	convert	VBN
cord-001835-0s7ok4uw	4496	8	into	into	IN
cord-001835-0s7ok4uw	4496	9	bio	bio	NN
cord-001835-0s7ok4uw	4496	10	-	-	NN
cord-001835-0s7ok4uw	4496	11	functionality	functionality	NN
cord-001835-0s7ok4uw	4496	12	(	(	-LRB-
cord-001835-0s7ok4uw	4496	13	Affinity	Affinity	NNP
cord-001835-0s7ok4uw	4496	14	)	)	-RRB-
cord-001835-0s7ok4uw	4496	15	.	.	.
cord-001835-0s7ok4uw	4497	1	Affinity	affinity	NN
cord-001835-0s7ok4uw	4497	2	between	between	IN
cord-001835-0s7ok4uw	4497	3	the	the	DT
cord-001835-0s7ok4uw	4497	4	two	two	CD
cord-001835-0s7ok4uw	4497	5	peptides	peptide	NNS
cord-001835-0s7ok4uw	4497	6	is	be	VBZ
cord-001835-0s7ok4uw	4497	7	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	4497	8	as	as	IN
cord-001835-0s7ok4uw	4497	9	significant	significant	JJ
cord-001835-0s7ok4uw	4497	10	amplitudes	amplitude	NNS
cord-001835-0s7ok4uw	4497	11	at	at	IN
cord-001835-0s7ok4uw	4497	12	the	the	DT
cord-001835-0s7ok4uw	4497	13	point	point	NN
cord-001835-0s7ok4uw	4497	14	of	of	IN
cord-001835-0s7ok4uw	4497	15	common	common	JJ
cord-001835-0s7ok4uw	4497	16	interaction	interaction	NN
cord-001835-0s7ok4uw	4497	17	also	also	RB
cord-001835-0s7ok4uw	4497	18	referred	refer	VBD
cord-001835-0s7ok4uw	4497	19	to	to	IN
cord-001835-0s7ok4uw	4497	20	as	as	IN
cord-001835-0s7ok4uw	4497	21	Consensus	Consensus	NNP
cord-001835-0s7ok4uw	4497	22	Frequency	Frequency	NNP
cord-001835-0s7ok4uw	4497	23	,	,	,
cord-001835-0s7ok4uw	4497	24	signifying	signify	VBG
cord-001835-0s7ok4uw	4497	25	remarkable	remarkable	JJ
cord-001835-0s7ok4uw	4497	26	affinity	affinity	NN
cord-001835-0s7ok4uw	4497	27	.	.	.
cord-001835-0s7ok4uw	4498	1	Discussions	discussion	NNS
cord-001835-0s7ok4uw	4498	2	:	:	:
cord-001835-0s7ok4uw	4499	1	Bio	Bio	NNP
cord-001835-0s7ok4uw	4499	2	-	-	HYPH
cord-001835-0s7ok4uw	4499	3	functionalities	functionality	NNS
cord-001835-0s7ok4uw	4499	4	of	of	IN
cord-001835-0s7ok4uw	4499	5	bio	bio	NN
cord-001835-0s7ok4uw	4499	6	-	-	NNS
cord-001835-0s7ok4uw	4499	7	molecules	molecule	NNS
cord-001835-0s7ok4uw	4499	8	are	be	VBP
cord-001835-0s7ok4uw	4499	9	known	know	VBN
cord-001835-0s7ok4uw	4499	10	to	to	TO
cord-001835-0s7ok4uw	4499	11	be	be	VB
cord-001835-0s7ok4uw	4499	12	expressed	express	VBN
cord-001835-0s7ok4uw	4499	13	in	in	IN
cord-001835-0s7ok4uw	4499	14	one	one	CD
cord-001835-0s7ok4uw	4499	15	or	or	CC
cord-001835-0s7ok4uw	4499	16	two	two	CD
cord-001835-0s7ok4uw	4499	17	genes	gene	NNS
cord-001835-0s7ok4uw	4499	18	,	,	,
cord-001835-0s7ok4uw	4499	19	which	which	WDT
cord-001835-0s7ok4uw	4499	20	have	have	VBP
cord-001835-0s7ok4uw	4499	21	been	be	VBN
cord-001835-0s7ok4uw	4499	22	found	find	VBN
cord-001835-0s7ok4uw	4499	23	to	to	TO
cord-001835-0s7ok4uw	4499	24	provide	provide	VB
cord-001835-0s7ok4uw	4499	25	as	as	RB
cord-001835-0s7ok4uw	4499	26	much	much	JJ
cord-001835-0s7ok4uw	4499	27	biological	biological	JJ
cord-001835-0s7ok4uw	4499	28	information	information	NN
cord-001835-0s7ok4uw	4499	29	as	as	IN
cord-001835-0s7ok4uw	4499	30	the	the	DT
cord-001835-0s7ok4uw	4499	31	bio	bio	NN
cord-001835-0s7ok4uw	4499	32	-	-	NNS
cord-001835-0s7ok4uw	4499	33	molecules	molecule	NNS
cord-001835-0s7ok4uw	4499	34	.	.	.
cord-001835-0s7ok4uw	4500	1	This	this	DT
cord-001835-0s7ok4uw	4500	2	indicates	indicate	VBZ
cord-001835-0s7ok4uw	4500	3	that	that	IN
cord-001835-0s7ok4uw	4500	4	biological	biological	JJ
cord-001835-0s7ok4uw	4500	5	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	4500	6	,	,	,
cord-001835-0s7ok4uw	4500	7	represented	represent	VBN
cord-001835-0s7ok4uw	4500	8	in	in	IN
cord-001835-0s7ok4uw	4500	9	these	these	DT
cord-001835-0s7ok4uw	4500	10	genes	gene	NNS
cord-001835-0s7ok4uw	4500	11	and	and	CC
cord-001835-0s7ok4uw	4500	12	proteins	protein	NNS
cord-001835-0s7ok4uw	4500	13	can	can	MD
cord-001835-0s7ok4uw	4500	14	now	now	RB
cord-001835-0s7ok4uw	4500	15	be	be	VB
cord-001835-0s7ok4uw	4500	16	extracted	extract	VBN
cord-001835-0s7ok4uw	4500	17	from	from	IN
cord-001835-0s7ok4uw	4500	18	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4500	19	sequence	sequence	NN
cord-001835-0s7ok4uw	4500	20	information	information	NN
cord-001835-0s7ok4uw	4500	21	.	.	.
cord-001835-0s7ok4uw	4501	1	For	for	IN
cord-001835-0s7ok4uw	4501	2	example	example	NN
cord-001835-0s7ok4uw	4501	3	,	,	,
cord-001835-0s7ok4uw	4501	4	multi	multi	JJ
cord-001835-0s7ok4uw	4501	5	-	-	JJ
cord-001835-0s7ok4uw	4501	6	drug	drug	JJ
cord-001835-0s7ok4uw	4501	7	resistances	resistance	NNS
cord-001835-0s7ok4uw	4501	8	arising	arise	VBG
cord-001835-0s7ok4uw	4501	9	from	from	IN
cord-001835-0s7ok4uw	4501	10	a	a	DT
cord-001835-0s7ok4uw	4501	11	variety	variety	JJ
cord-001835-0s7ok4uw	4501	12	anti	anti	JJ
cord-001835-0s7ok4uw	4501	13	-	-	JJ
cord-001835-0s7ok4uw	4501	14	microbial	microbial	JJ
cord-001835-0s7ok4uw	4501	15	agent	agent	NN
cord-001835-0s7ok4uw	4501	16	from	from	IN
cord-001835-0s7ok4uw	4501	17	several	several	JJ
cord-001835-0s7ok4uw	4501	18	classes	class	NNS
cord-001835-0s7ok4uw	4501	19	including	include	VBG
cord-001835-0s7ok4uw	4501	20	alkaloids	alkaloid	NNS
cord-001835-0s7ok4uw	4501	21	,	,	,
cord-001835-0s7ok4uw	4501	22	flavonoids	flavonoid	NNS
cord-001835-0s7ok4uw	4501	23	,	,	,
cord-001835-0s7ok4uw	4501	24	etc	etc	FW
cord-001835-0s7ok4uw	4501	25	can	can	MD
cord-001835-0s7ok4uw	4501	26	be	be	VB
cord-001835-0s7ok4uw	4501	27	retrieved	retrieve	VBN
cord-001835-0s7ok4uw	4501	28	from	from	IN
cord-001835-0s7ok4uw	4501	29	the	the	DT
cord-001835-0s7ok4uw	4501	30	sequence	sequence	NN
cord-001835-0s7ok4uw	4501	31	information	information	NN
cord-001835-0s7ok4uw	4501	32	of	of	IN
cord-001835-0s7ok4uw	4501	33	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4501	34	encoding	encoding	NN
cord-001835-0s7ok4uw	4501	35	genes	gene	NNS
cord-001835-0s7ok4uw	4501	36	(	(	-LRB-
cord-001835-0s7ok4uw	4501	37	MDR1	MDR1	NNP
cord-001835-0s7ok4uw	4501	38	and	and	CC
cord-001835-0s7ok4uw	4501	39	MDR11	MDR11	NNP
cord-001835-0s7ok4uw	4501	40	)	)	-RRB-
cord-001835-0s7ok4uw	4501	41	.	.	.
cord-001835-0s7ok4uw	4502	1	Similarly	similarly	RB
cord-001835-0s7ok4uw	4502	2	,	,	,
cord-001835-0s7ok4uw	4502	3	translation	translation	NN
cord-001835-0s7ok4uw	4502	4	of	of	IN
cord-001835-0s7ok4uw	4502	5	HIV	HIV	NNP
cord-001835-0s7ok4uw	4502	6	infection	infection	NN
cord-001835-0s7ok4uw	4502	7	to	to	IN
cord-001835-0s7ok4uw	4502	8	AIDS	AIDS	NNP
cord-001835-0s7ok4uw	4502	9	disease	disease	NN
cord-001835-0s7ok4uw	4502	10	can	can	MD
cord-001835-0s7ok4uw	4502	11	be	be	VB
cord-001835-0s7ok4uw	4502	12	extracted	extract	VBN
cord-001835-0s7ok4uw	4502	13	from	from	IN
cord-001835-0s7ok4uw	4502	14	the	the	DT
cord-001835-0s7ok4uw	4502	15	protein	protein	NN
cord-001835-0s7ok4uw	4502	16	sequence	sequence	NN
cord-001835-0s7ok4uw	4502	17	alterations	alteration	NNS
cord-001835-0s7ok4uw	4502	18	in	in	IN
cord-001835-0s7ok4uw	4502	19	the	the	DT
cord-001835-0s7ok4uw	4502	20	HIV	HIV	NNP
cord-001835-0s7ok4uw	4502	21	gp120	gp120	NNP
cord-001835-0s7ok4uw	4502	22	.	.	.
cord-001835-0s7ok4uw	4503	1	Similarly	similarly	RB
cord-001835-0s7ok4uw	4503	2	,	,	,
cord-001835-0s7ok4uw	4503	3	effectiveness	effectiveness	NN
cord-001835-0s7ok4uw	4503	4	of	of	IN
cord-001835-0s7ok4uw	4503	5	anti	anti	JJ
cord-001835-0s7ok4uw	4503	6	-	-	JJ
cord-001835-0s7ok4uw	4503	7	retroviral	retroviral	JJ
cord-001835-0s7ok4uw	4503	8	agent	agent	NN
cord-001835-0s7ok4uw	4504	1	,	,	,
cord-001835-0s7ok4uw	4504	2	Maraviroc	Maraviroc	NNP
cord-001835-0s7ok4uw	4504	3	on	on	IN
cord-001835-0s7ok4uw	4504	4	the	the	DT
cord-001835-0s7ok4uw	4504	5	HIV	HIV	NNP
cord-001835-0s7ok4uw	4504	6	isolate	isolate	VB
cord-001835-0s7ok4uw	4504	7	H2BX2	H2BX2	NNP
cord-001835-0s7ok4uw	4504	8	and	and	CC
cord-001835-0s7ok4uw	4504	9	NDK	NDK	NNP
cord-001835-0s7ok4uw	4504	10	can	can	MD
cord-001835-0s7ok4uw	4504	11	be	be	VB
cord-001835-0s7ok4uw	4504	12	deciphered	decipher	VBN
cord-001835-0s7ok4uw	4504	13	from	from	IN
cord-001835-0s7ok4uw	4504	14	the	the	DT
cord-001835-0s7ok4uw	4504	15	sequence	sequence	NN
cord-001835-0s7ok4uw	4504	16	information	information	NN
cord-001835-0s7ok4uw	4504	17	of	of	IN
cord-001835-0s7ok4uw	4504	18	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4504	19	V3	v3	NN
cord-001835-0s7ok4uw	4504	20	observed	observe	VBD
cord-001835-0s7ok4uw	4504	21	at	at	IN
cord-001835-0s7ok4uw	4504	22	the	the	DT
cord-001835-0s7ok4uw	4504	23	predicted	predict	VBN
cord-001835-0s7ok4uw	4504	24	sequences	sequence	NNS
cord-001835-0s7ok4uw	4504	25	.	.	.
cord-001835-0s7ok4uw	4505	1	These	these	DT
cord-001835-0s7ok4uw	4505	2	positions	position	NNS
cord-001835-0s7ok4uw	4505	3	are	be	VBP
cord-001835-0s7ok4uw	4505	4	important	important	JJ
cord-001835-0s7ok4uw	4505	5	as	as	IN
cord-001835-0s7ok4uw	4505	6	they	-PRON-	PRP
cord-001835-0s7ok4uw	4505	7	surround	surround	VBP
cord-001835-0s7ok4uw	4505	8	the	the	DT
cord-001835-0s7ok4uw	4505	9	cleavage	cleavage	NN
cord-001835-0s7ok4uw	4505	10	site	site	NN
cord-001835-0s7ok4uw	4505	11	in	in	IN
cord-001835-0s7ok4uw	4505	12	the	the	DT
cord-001835-0s7ok4uw	4505	13	three	three	CD
cord-001835-0s7ok4uw	4505	14	-	-	HYPH
cord-001835-0s7ok4uw	4505	15	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	4505	16	structure	structure	NN
cord-001835-0s7ok4uw	4505	17	,	,	,
cord-001835-0s7ok4uw	4505	18	and	and	CC
cord-001835-0s7ok4uw	4505	19	are	be	VBP
cord-001835-0s7ok4uw	4505	20	probably	probably	RB
cord-001835-0s7ok4uw	4505	21	less	less	RBR
cord-001835-0s7ok4uw	4505	22	tolerant	tolerant	JJ
cord-001835-0s7ok4uw	4505	23	to	to	TO
cord-001835-0s7ok4uw	4505	24	change	change	VB
cord-001835-0s7ok4uw	4505	25	.	.	.
cord-001835-0s7ok4uw	4506	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	4506	2	in	in	IN
cord-001835-0s7ok4uw	4506	3	previous	previous	JJ
cord-001835-0s7ok4uw	4506	4	studies	study	NNS
cord-001835-0s7ok4uw	4506	5	,	,	,
cord-001835-0s7ok4uw	4506	6	Cys	Cys	NNP
cord-001835-0s7ok4uw	4506	7	at	at	IN
cord-001835-0s7ok4uw	4506	8	P1	P1	NNP
cord-001835-0s7ok4uw	4506	9	position	position	NN
cord-001835-0s7ok4uw	4506	10	has	have	VBZ
cord-001835-0s7ok4uw	4506	11	been	be	VBN
cord-001835-0s7ok4uw	4506	12	shown	show	VBN
cord-001835-0s7ok4uw	4506	13	to	to	TO
cord-001835-0s7ok4uw	4506	14	be	be	VB
cord-001835-0s7ok4uw	4506	15	the	the	DT
cord-001835-0s7ok4uw	4506	16	dominant	dominant	JJ
cord-001835-0s7ok4uw	4506	17	determinant	determinant	NN
cord-001835-0s7ok4uw	4506	18	for	for	IN
cord-001835-0s7ok4uw	4506	19	cleavage	cleavage	NN
cord-001835-0s7ok4uw	4506	20	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4506	21	,	,	,
cord-001835-0s7ok4uw	4506	22	while	while	IN
cord-001835-0s7ok4uw	4506	23	Cys	Cys	NNP
cord-001835-0s7ok4uw	4506	24	,	,	,
cord-001835-0s7ok4uw	4506	25	Pro	Pro	NNP
cord-001835-0s7ok4uw	4506	26	and	and	CC
cord-001835-0s7ok4uw	4506	27	Glu	Glu	NNP
cord-001835-0s7ok4uw	4506	28	at	at	IN
cord-001835-0s7ok4uw	4506	29	P2	P2	NNP
cord-001835-0s7ok4uw	4506	30	position	position	NN
cord-001835-0s7ok4uw	4506	31	have	have	VBP
cord-001835-0s7ok4uw	4506	32	also	also	RB
cord-001835-0s7ok4uw	4506	33	been	be	VBN
cord-001835-0s7ok4uw	4506	34	shown	show	VBN
cord-001835-0s7ok4uw	4506	35	to	to	TO
cord-001835-0s7ok4uw	4506	36	be	be	VB
cord-001835-0s7ok4uw	4506	37	correlated	correlate	VBN
cord-001835-0s7ok4uw	4506	38	with	with	IN
cord-001835-0s7ok4uw	4506	39	increased	increase	VBN
cord-001835-0s7ok4uw	4506	40	cleavage	cleavage	NN
cord-001835-0s7ok4uw	4506	41	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4506	42	of	of	IN
cord-001835-0s7ok4uw	4506	43	NS3/4A	ns3/4a	JJ
cord-001835-0s7ok4uw	4506	44	protease	protease	NN
cord-001835-0s7ok4uw	4506	45	.	.	.
cord-001835-0s7ok4uw	4507	1	For	for	IN
cord-001835-0s7ok4uw	4507	2	AdV2	adv2	JJ
cord-001835-0s7ok4uw	4507	3	cysteine	cysteine	NN
cord-001835-0s7ok4uw	4507	4	protease	protease	NN
cord-001835-0s7ok4uw	4507	5	,	,	,
cord-001835-0s7ok4uw	4507	6	on	on	IN
cord-001835-0s7ok4uw	4507	7	the	the	DT
cord-001835-0s7ok4uw	4507	8	other	other	JJ
cord-001835-0s7ok4uw	4507	9	hand	hand	NN
cord-001835-0s7ok4uw	4507	10	,	,	,
cord-001835-0s7ok4uw	4507	11	BSST	BSST	NNP
cord-001835-0s7ok4uw	4507	12	produces	produce	VBZ
cord-001835-0s7ok4uw	4507	13	similar	similar	JJ
cord-001835-0s7ok4uw	4507	14	significant	significant	JJ
cord-001835-0s7ok4uw	4507	15	results	result	NNS
cord-001835-0s7ok4uw	4507	16	for	for	IN
cord-001835-0s7ok4uw	4507	17	both	both	DT
cord-001835-0s7ok4uw	4507	18	type	type	NN
cord-001835-0s7ok4uw	4507	19	1	1	CD
cord-001835-0s7ok4uw	4507	20	(	(	-LRB-
cord-001835-0s7ok4uw	4507	21	XGX	xgx	NN
cord-001835-0s7ok4uw	4507	22	-	-	HYPH
cord-001835-0s7ok4uw	4507	23	G	G	NNP
cord-001835-0s7ok4uw	4507	24	)	)	-RRB-
cord-001835-0s7ok4uw	4507	25	and	and	CC
cord-001835-0s7ok4uw	4507	26	type	type	NN
cord-001835-0s7ok4uw	4507	27	2	2	CD
cord-001835-0s7ok4uw	4508	1	(	(	-LRB-
cord-001835-0s7ok4uw	4508	2	XGG	XGG	NNP
cord-001835-0s7ok4uw	4508	3	-	-	HYPH
cord-001835-0s7ok4uw	4508	4	X	x	NN
cord-001835-0s7ok4uw	4508	5	)	)	-RRB-
cord-001835-0s7ok4uw	4508	6	consensus	consensus	NN
cord-001835-0s7ok4uw	4508	7	cleavage	cleavage	NN
cord-001835-0s7ok4uw	4508	8	sites	site	NNS
cord-001835-0s7ok4uw	4508	9	,	,	,
cord-001835-0s7ok4uw	4508	10	where	where	WRB
cord-001835-0s7ok4uw	4508	11	P2	P2	NNP
cord-001835-0s7ok4uw	4508	12	and	and	CC
cord-001835-0s7ok4uw	4508	13	P1	P1	NNP
cord-001835-0s7ok4uw	4508	14	'	'	POS
cord-001835-0s7ok4uw	4508	15	positions	position	NNS
cord-001835-0s7ok4uw	4508	16	have	have	VBP
cord-001835-0s7ok4uw	4508	17	Gly	Gly	NNP
cord-001835-0s7ok4uw	4508	18	with	with	IN
cord-001835-0s7ok4uw	4508	19	highest	high	JJS
cord-001835-0s7ok4uw	4508	20	percentage	percentage	NN
cord-001835-0s7ok4uw	4508	21	in	in	IN
cord-001835-0s7ok4uw	4508	22	type	type	NN
cord-001835-0s7ok4uw	4508	23	1	1	CD
cord-001835-0s7ok4uw	4508	24	(	(	-LRB-
cord-001835-0s7ok4uw	4508	25	XGX	xgx	NN
cord-001835-0s7ok4uw	4508	26	-	-	HYPH
cord-001835-0s7ok4uw	4508	27	G	G	NNP
cord-001835-0s7ok4uw	4508	28	)	)	-RRB-
cord-001835-0s7ok4uw	4508	29	while	while	IN
cord-001835-0s7ok4uw	4508	30	P2	P2	NNP
cord-001835-0s7ok4uw	4508	31	and	and	CC
cord-001835-0s7ok4uw	4508	32	P1	P1	NNP
cord-001835-0s7ok4uw	4508	33	positions	position	NNS
cord-001835-0s7ok4uw	4508	34	have	have	VBP
cord-001835-0s7ok4uw	4508	35	Gly	Gly	NNP
cord-001835-0s7ok4uw	4508	36	in	in	IN
cord-001835-0s7ok4uw	4508	37	type	type	NN
cord-001835-0s7ok4uw	4508	38	2	2	CD
cord-001835-0s7ok4uw	4509	1	(	(	-LRB-
cord-001835-0s7ok4uw	4509	2	XGG	XGG	NNP
cord-001835-0s7ok4uw	4509	3	-	-	HYPH
cord-001835-0s7ok4uw	4509	4	X	X	NNP
cord-001835-0s7ok4uw	4509	5	)	)	-RRB-
cord-001835-0s7ok4uw	4509	6	.	.	.
cord-001835-0s7ok4uw	4510	1	These	these	DT
cord-001835-0s7ok4uw	4510	2	indicate	indicate	VBP
cord-001835-0s7ok4uw	4510	3	that	that	IN
cord-001835-0s7ok4uw	4510	4	the	the	DT
cord-001835-0s7ok4uw	4510	5	BSST	BSST	NNP
cord-001835-0s7ok4uw	4510	6	seems	seem	VBZ
cord-001835-0s7ok4uw	4510	7	to	to	TO
cord-001835-0s7ok4uw	4510	8	provide	provide	VB
cord-001835-0s7ok4uw	4510	9	a	a	DT
cord-001835-0s7ok4uw	4510	10	powerful	powerful	JJ
cord-001835-0s7ok4uw	4510	11	methodology	methodology	NN
cord-001835-0s7ok4uw	4510	12	for	for	IN
cord-001835-0s7ok4uw	4510	13	predicting	predict	VBG
cord-001835-0s7ok4uw	4510	14	the	the	DT
cord-001835-0s7ok4uw	4510	15	substrate	substrate	JJ
cord-001835-0s7ok4uw	4510	16	specificity	specificity	NN
cord-001835-0s7ok4uw	4510	17	for	for	IN
cord-001835-0s7ok4uw	4510	18	the	the	DT
cord-001835-0s7ok4uw	4510	19	HCV	HCV	NNP
cord-001835-0s7ok4uw	4510	20	NS3/4A	ns3/4a	NN
cord-001835-0s7ok4uw	4510	21	serine	serine	NN
cord-001835-0s7ok4uw	4510	22	protease	protease	NN
cord-001835-0s7ok4uw	4510	23	and	and	CC
cord-001835-0s7ok4uw	4510	24	AdV2	adv2	NN
cord-001835-0s7ok4uw	4510	25	cysteine	cysteine	NN
cord-001835-0s7ok4uw	4510	26	protease	protease	NN
cord-001835-0s7ok4uw	4510	27	,	,	,
cord-001835-0s7ok4uw	4510	28	which	which	WDT
cord-001835-0s7ok4uw	4510	29	are	be	VBP
cord-001835-0s7ok4uw	4510	30	targets	target	NNS
cord-001835-0s7ok4uw	4510	31	in	in	IN
cord-001835-0s7ok4uw	4510	32	drug	drug	NN
cord-001835-0s7ok4uw	4510	33	discovery	discovery	NN
cord-001835-0s7ok4uw	4510	34	studies	study	NNS
cord-001835-0s7ok4uw	4510	35	.	.	.
cord-001835-0s7ok4uw	4511	1	Protein	protein	NN
cord-001835-0s7ok4uw	4511	2	plasticity	plasticity	NN
cord-001835-0s7ok4uw	4511	3	improves	improve	VBZ
cord-001835-0s7ok4uw	4511	4	protein	protein	NN
cord-001835-0s7ok4uw	4511	5	-	-	HYPH
cord-001835-0s7ok4uw	4511	6	protein	protein	NN
cord-001835-0s7ok4uw	4511	7	binding	binding	NN
cord-001835-0s7ok4uw	4511	8	description	description	NN
cord-001835-0s7ok4uw	4511	9	Chiara	Chiara	NNP
cord-001835-0s7ok4uw	4511	10	Pallara	Pallara	NNP
cord-001835-0s7ok4uw	4511	11	1	1	CD
cord-001835-0s7ok4uw	4511	12	,	,	,
cord-001835-0s7ok4uw	4511	13	Juan	Juan	NNP
cord-001835-0s7ok4uw	4511	14	Fern	Fern	NNP
cord-001835-0s7ok4uw	4512	1	andez	andez	NNP
cord-001835-0s7ok4uw	4512	2	-	-	HYPH
cord-001835-0s7ok4uw	4512	3	Recio	Recio	NNP
cord-001835-0s7ok4uw	4512	4	1	1	CD
cord-001835-0s7ok4uw	4512	5	1	1	CD
cord-001835-0s7ok4uw	4513	1	An	an	DT
cord-001835-0s7ok4uw	4513	2	accurate	accurate	JJ
cord-001835-0s7ok4uw	4513	3	description	description	NN
cord-001835-0s7ok4uw	4513	4	of	of	IN
cord-001835-0s7ok4uw	4513	5	protein	protein	NN
cord-001835-0s7ok4uw	4513	6	-	-	HYPH
cord-001835-0s7ok4uw	4513	7	protein	protein	NN
cord-001835-0s7ok4uw	4513	8	interactions	interaction	NNS
cord-001835-0s7ok4uw	4513	9	at	at	IN
cord-001835-0s7ok4uw	4513	10	atomic	atomic	JJ
cord-001835-0s7ok4uw	4513	11	level	level	NN
cord-001835-0s7ok4uw	4513	12	is	be	VBZ
cord-001835-0s7ok4uw	4513	13	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	4513	14	to	to	TO
cord-001835-0s7ok4uw	4513	15	understand	understand	VB
cord-001835-0s7ok4uw	4513	16	cellular	cellular	JJ
cord-001835-0s7ok4uw	4513	17	processes	process	NNS
cord-001835-0s7ok4uw	4513	18	.	.	.
cord-001835-0s7ok4uw	4514	1	However	however	RB
cord-001835-0s7ok4uw	4514	2	the	the	DT
cord-001835-0s7ok4uw	4514	3	current	current	JJ
cord-001835-0s7ok4uw	4514	4	structural	structural	JJ
cord-001835-0s7ok4uw	4514	5	coverage	coverage	NN
cord-001835-0s7ok4uw	4514	6	of	of	IN
cord-001835-0s7ok4uw	4514	7	protein	protein	NN
cord-001835-0s7ok4uw	4514	8	-	-	HYPH
cord-001835-0s7ok4uw	4514	9	protein	protein	NN
cord-001835-0s7ok4uw	4514	10	interactions	interaction	NNS
cord-001835-0s7ok4uw	4514	11	(	(	-LRB-
cord-001835-0s7ok4uw	4514	12	i.e.	i.e.	FW
cord-001835-0s7ok4uw	4514	13	available	available	JJ
cord-001835-0s7ok4uw	4514	14	experimental	experimental	JJ
cord-001835-0s7ok4uw	4514	15	structures	structure	NNS
cord-001835-0s7ok4uw	4514	16	plus	plus	IN
cord-001835-0s7ok4uw	4514	17	potential	potential	JJ
cord-001835-0s7ok4uw	4514	18	models	model	NNS
cord-001835-0s7ok4uw	4514	19	based	base	VBN
cord-001835-0s7ok4uw	4514	20	on	on	IN
cord-001835-0s7ok4uw	4514	21	homologous	homologous	JJ
cord-001835-0s7ok4uw	4514	22	complex	complex	JJ
cord-001835-0s7ok4uw	4514	23	structures	structure	NNS
cord-001835-0s7ok4uw	4514	24	)	)	-RRB-
cord-001835-0s7ok4uw	4514	25	is	be	VBZ
cord-001835-0s7ok4uw	4514	26	below	below	IN
cord-001835-0s7ok4uw	4514	27	4	4	CD
cord-001835-0s7ok4uw	4514	28	%	%	NN
cord-001835-0s7ok4uw	4514	29	of	of	IN
cord-001835-0s7ok4uw	4514	30	the	the	DT
cord-001835-0s7ok4uw	4514	31	estimated	estimate	VBN
cord-001835-0s7ok4uw	4514	32	number	number	NN
cord-001835-0s7ok4uw	4514	33	of	of	IN
cord-001835-0s7ok4uw	4514	34	possible	possible	JJ
cord-001835-0s7ok4uw	4514	35	complexes	complex	NNS
cord-001835-0s7ok4uw	4514	36	formed	form	VBN
cord-001835-0s7ok4uw	4514	37	between	between	IN
cord-001835-0s7ok4uw	4514	38	human	human	NN
cord-001835-0s7ok4uw	4514	39	proteins.1,2	proteins.1,2	NNS
cord-001835-0s7ok4uw	4515	1	For	for	IN
cord-001835-0s7ok4uw	4515	2	these	these	DT
cord-001835-0s7ok4uw	4515	3	reasons	reason	NNS
cord-001835-0s7ok4uw	4515	4	,	,	,
cord-001835-0s7ok4uw	4515	5	computational	computational	JJ
cord-001835-0s7ok4uw	4515	6	docking	docking	NN
cord-001835-0s7ok4uw	4515	7	methods	method	NNS
cord-001835-0s7ok4uw	4515	8	aim	aim	VBP
cord-001835-0s7ok4uw	4515	9	to	to	TO
cord-001835-0s7ok4uw	4515	10	become	become	VB
cord-001835-0s7ok4uw	4515	11	a	a	DT
cord-001835-0s7ok4uw	4515	12	complementary	complementary	JJ
cord-001835-0s7ok4uw	4515	13	approach	approach	NN
cord-001835-0s7ok4uw	4515	14	not	not	RB
cord-001835-0s7ok4uw	4515	15	only	only	RB
cord-001835-0s7ok4uw	4515	16	to	to	TO
cord-001835-0s7ok4uw	4515	17	solve	solve	VB
cord-001835-0s7ok4uw	4515	18	the	the	DT
cord-001835-0s7ok4uw	4515	19	structural	structural	JJ
cord-001835-0s7ok4uw	4515	20	interactome	interactome	NN
cord-001835-0s7ok4uw	4515	21	but	but	CC
cord-001835-0s7ok4uw	4515	22	also	also	RB
cord-001835-0s7ok4uw	4515	23	to	to	TO
cord-001835-0s7ok4uw	4515	24	elucidate	elucidate	VB
cord-001835-0s7ok4uw	4515	25	the	the	DT
cord-001835-0s7ok4uw	4515	26	basis	basis	NN
cord-001835-0s7ok4uw	4515	27	of	of	IN
cord-001835-0s7ok4uw	4515	28	the	the	DT
cord-001835-0s7ok4uw	4515	29	protein	protein	NN
cord-001835-0s7ok4uw	4515	30	-	-	HYPH
cord-001835-0s7ok4uw	4515	31	protein	protein	NN
cord-001835-0s7ok4uw	4515	32	association	association	NN
cord-001835-0s7ok4uw	4515	33	mechanism	mechanism	NN
cord-001835-0s7ok4uw	4515	34	.	.	.
cord-001835-0s7ok4uw	4516	1	In	in	IN
cord-001835-0s7ok4uw	4516	2	spite	spite	NN
cord-001835-0s7ok4uw	4516	3	of	of	IN
cord-001835-0s7ok4uw	4516	4	the	the	DT
cord-001835-0s7ok4uw	4516	5	advances	advance	NNS
cord-001835-0s7ok4uw	4516	6	in	in	IN
cord-001835-0s7ok4uw	4516	7	protein	protein	NN
cord-001835-0s7ok4uw	4516	8	-	-	HYPH
cord-001835-0s7ok4uw	4516	9	protein	protein	NN
cord-001835-0s7ok4uw	4516	10	binding	bind	VBG
cord-001835-0s7ok4uw	4516	11	description	description	NN
cord-001835-0s7ok4uw	4516	12	by	by	IN
cord-001835-0s7ok4uw	4516	13	docking	docking	NN
cord-001835-0s7ok4uw	4516	14	,	,	,
cord-001835-0s7ok4uw	4516	15	dealing	deal	VBG
cord-001835-0s7ok4uw	4516	16	with	with	IN
cord-001835-0s7ok4uw	4516	17	molecular	molecular	JJ
cord-001835-0s7ok4uw	4516	18	flexibility	flexibility	NN
cord-001835-0s7ok4uw	4516	19	is	be	VBZ
cord-001835-0s7ok4uw	4516	20	a	a	DT
cord-001835-0s7ok4uw	4516	21	major	major	JJ
cord-001835-0s7ok4uw	4516	22	bottle	bottle	NN
cord-001835-0s7ok4uw	4516	23	-	-	HYPH
cord-001835-0s7ok4uw	4516	24	neck	neck	NN
cord-001835-0s7ok4uw	4516	25	,	,	,
cord-001835-0s7ok4uw	4516	26	as	as	IN
cord-001835-0s7ok4uw	4516	27	shown	show	VBN
cord-001835-0s7ok4uw	4516	28	by	by	IN
cord-001835-0s7ok4uw	4516	29	the	the	DT
cord-001835-0s7ok4uw	4516	30	recent	recent	JJ
cord-001835-0s7ok4uw	4516	31	outcomes	outcome	NNS
cord-001835-0s7ok4uw	4516	32	of	of	IN
cord-001835-0s7ok4uw	4516	33	the	the	DT
cord-001835-0s7ok4uw	4516	34	CAPRI	CAPRI	NNP
cord-001835-0s7ok4uw	4516	35	(	(	-LRB-
cord-001835-0s7ok4uw	4516	36	Critical	Critical	NNP
cord-001835-0s7ok4uw	4516	37	Assessment	Assessment	NNP
cord-001835-0s7ok4uw	4516	38	of	of	IN
cord-001835-0s7ok4uw	4516	39	PRediction	PRediction	NNP
cord-001835-0s7ok4uw	4516	40	of	of	IN
cord-001835-0s7ok4uw	4516	41	Interactions	Interactions	NNPS
cord-001835-0s7ok4uw	4516	42	)	)	-RRB-
cord-001835-0s7ok4uw	4516	43	experiment.3	experiment.3	,
cord-001835-0s7ok4uw	4517	1	This	this	DT
cord-001835-0s7ok4uw	4517	2	data	data	NN
cord-001835-0s7ok4uw	4517	3	clearly	clearly	RB
cord-001835-0s7ok4uw	4517	4	confirms	confirm	VBZ
cord-001835-0s7ok4uw	4517	5	that	that	IN
cord-001835-0s7ok4uw	4517	6	the	the	DT
cord-001835-0s7ok4uw	4517	7	protein	protein	NN
cord-001835-0s7ok4uw	4517	8	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	4517	9	plays	play	VBZ
cord-001835-0s7ok4uw	4517	10	a	a	DT
cord-001835-0s7ok4uw	4517	11	key	key	JJ
cord-001835-0s7ok4uw	4517	12	role	role	NN
cord-001835-0s7ok4uw	4517	13	in	in	IN
cord-001835-0s7ok4uw	4517	14	protein	protein	NN
cord-001835-0s7ok4uw	4517	15	-	-	HYPH
cord-001835-0s7ok4uw	4517	16	protein	protein	NN
cord-001835-0s7ok4uw	4517	17	association	association	NN
cord-001835-0s7ok4uw	4517	18	.	.	.
cord-001835-0s7ok4uw	4518	1	The	the	DT
cord-001835-0s7ok4uw	4518	2	use	use	NN
cord-001835-0s7ok4uw	4518	3	of	of	IN
cord-001835-0s7ok4uw	4518	4	conformational	conformational	JJ
cord-001835-0s7ok4uw	4518	5	ensembles	ensemble	NNS
cord-001835-0s7ok4uw	4518	6	generated	generate	VBN
cord-001835-0s7ok4uw	4518	7	from	from	IN
cord-001835-0s7ok4uw	4518	8	unbound	unbound	JJ
cord-001835-0s7ok4uw	4518	9	protein	protein	NN
cord-001835-0s7ok4uw	4518	10	structures	structure	NNS
cord-001835-0s7ok4uw	4518	11	in	in	IN
cord-001835-0s7ok4uw	4518	12	combination	combination	NN
cord-001835-0s7ok4uw	4518	13	with	with	IN
cord-001835-0s7ok4uw	4518	14	computational	computational	JJ
cord-001835-0s7ok4uw	4518	15	docking	docking	NN
cord-001835-0s7ok4uw	4518	16	simulations	simulation	NNS
cord-001835-0s7ok4uw	4518	17	might	may	MD
cord-001835-0s7ok4uw	4518	18	represent	represent	VB
cord-001835-0s7ok4uw	4518	19	a	a	DT
cord-001835-0s7ok4uw	4518	20	more	more	RBR
cord-001835-0s7ok4uw	4518	21	realistic	realistic	JJ
cord-001835-0s7ok4uw	4518	22	description	description	NN
cord-001835-0s7ok4uw	4518	23	of	of	IN
cord-001835-0s7ok4uw	4518	24	protein	protein	NN
cord-001835-0s7ok4uw	4518	25	-	-	HYPH
cord-001835-0s7ok4uw	4518	26	protein	protein	NN
cord-001835-0s7ok4uw	4518	27	association	association	NN
cord-001835-0s7ok4uw	4518	28	.	.	.
cord-001835-0s7ok4uw	4519	1	Here	here	RB
cord-001835-0s7ok4uw	4519	2	,	,	,
cord-001835-0s7ok4uw	4519	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4519	4	present	present	VBP
cord-001835-0s7ok4uw	4519	5	the	the	DT
cord-001835-0s7ok4uw	4519	6	first	first	JJ
cord-001835-0s7ok4uw	4519	7	systematic	systematic	JJ
cord-001835-0s7ok4uw	4519	8	study	study	NN
cord-001835-0s7ok4uw	4519	9	about	about	IN
cord-001835-0s7ok4uw	4519	10	the	the	DT
cord-001835-0s7ok4uw	4519	11	use	use	NN
cord-001835-0s7ok4uw	4519	12	of	of	IN
cord-001835-0s7ok4uw	4519	13	precomputed	precomputed	JJ
cord-001835-0s7ok4uw	4519	14	unbound	unbound	JJ
cord-001835-0s7ok4uw	4519	15	ensembles	ensemble	NNS
cord-001835-0s7ok4uw	4519	16	in	in	IN
cord-001835-0s7ok4uw	4519	17	docking	docking	NN
cord-001835-0s7ok4uw	4519	18	,	,	,
cord-001835-0s7ok4uw	4519	19	as	as	IN
cord-001835-0s7ok4uw	4519	20	performed	perform	VBN
cord-001835-0s7ok4uw	4519	21	on	on	IN
cord-001835-0s7ok4uw	4519	22	a	a	DT
cord-001835-0s7ok4uw	4519	23	set	set	NN
cord-001835-0s7ok4uw	4519	24	of	of	IN
cord-001835-0s7ok4uw	4519	25	124	124	CD
cord-001835-0s7ok4uw	4519	26	cases	case	NNS
cord-001835-0s7ok4uw	4519	27	of	of	IN
cord-001835-0s7ok4uw	4519	28	the	the	DT
cord-001835-0s7ok4uw	4519	29	Protein	Protein	NNP
cord-001835-0s7ok4uw	4519	30	-	-	HYPH
cord-001835-0s7ok4uw	4519	31	Protein	Protein	NNP
cord-001835-0s7ok4uw	4519	32	Docking	Docking	NNP
cord-001835-0s7ok4uw	4519	33	Benchmark	Benchmark	NNP
cord-001835-0s7ok4uw	4519	34	3.0.4	3.0.4	NNS
cord-001835-0s7ok4uw	4520	1	The	the	DT
cord-001835-0s7ok4uw	4520	2	primary	primary	JJ
cord-001835-0s7ok4uw	4520	3	aim	aim	NN
cord-001835-0s7ok4uw	4520	4	of	of	IN
cord-001835-0s7ok4uw	4520	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4520	6	work	work	NN
cord-001835-0s7ok4uw	4520	7	is	be	VBZ
cord-001835-0s7ok4uw	4520	8	to	to	TO
cord-001835-0s7ok4uw	4520	9	understand	understand	VB
cord-001835-0s7ok4uw	4520	10	the	the	DT
cord-001835-0s7ok4uw	4520	11	role	role	NN
cord-001835-0s7ok4uw	4520	12	of	of	IN
cord-001835-0s7ok4uw	4520	13	the	the	DT
cord-001835-0s7ok4uw	4520	14	protein	protein	NN
cord-001835-0s7ok4uw	4520	15	conformational	conformational	JJ
cord-001835-0s7ok4uw	4520	16	heterogeneity	heterogeneity	NN
cord-001835-0s7ok4uw	4520	17	in	in	IN
cord-001835-0s7ok4uw	4520	18	protein	protein	NN
cord-001835-0s7ok4uw	4520	19	-	-	HYPH
cord-001835-0s7ok4uw	4520	20	protein	protein	NN
cord-001835-0s7ok4uw	4520	21	recognition	recognition	NN
cord-001835-0s7ok4uw	4520	22	.	.	.
cord-001835-0s7ok4uw	4521	1	To	to	TO
cord-001835-0s7ok4uw	4521	2	do	do	VB
cord-001835-0s7ok4uw	4521	3	this	this	DT
cord-001835-0s7ok4uw	4521	4	,	,	,
cord-001835-0s7ok4uw	4521	5	small	small	JJ
cord-001835-0s7ok4uw	4521	6	conformational	conformational	JJ
cord-001835-0s7ok4uw	4521	7	ensembles	ensemble	NNS
cord-001835-0s7ok4uw	4521	8	were	be	VBD
cord-001835-0s7ok4uw	4521	9	automatically	automatically	RB
cord-001835-0s7ok4uw	4521	10	generated	generate	VBN
cord-001835-0s7ok4uw	4521	11	starting	start	VBG
cord-001835-0s7ok4uw	4521	12	from	from	IN
cord-001835-0s7ok4uw	4521	13	the	the	DT
cord-001835-0s7ok4uw	4521	14	unbound	unbound	JJ
cord-001835-0s7ok4uw	4521	15	docking	docking	NN
cord-001835-0s7ok4uw	4521	16	partners	partner	NNS
cord-001835-0s7ok4uw	4521	17	,	,	,
cord-001835-0s7ok4uw	4521	18	and	and	CC
cord-001835-0s7ok4uw	4521	19	then	then	RB
cord-001835-0s7ok4uw	4521	20	an	an	DT
cord-001835-0s7ok4uw	4521	21	extensive	extensive	JJ
cord-001835-0s7ok4uw	4521	22	analysis	analysis	NN
cord-001835-0s7ok4uw	4521	23	of	of	IN
cord-001835-0s7ok4uw	4521	24	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4521	25	binding	bind	VBG
cord-001835-0s7ok4uw	4521	26	properties	property	NNS
cord-001835-0s7ok4uw	4521	27	was	be	VBD
cord-001835-0s7ok4uw	4521	28	performed	perform	VBN
cord-001835-0s7ok4uw	4521	29	in	in	IN
cord-001835-0s7ok4uw	4521	30	the	the	DT
cord-001835-0s7ok4uw	4521	31	context	context	NN
cord-001835-0s7ok4uw	4521	32	of	of	IN
cord-001835-0s7ok4uw	4521	33	pyDock	pyDock	NNP
cord-001835-0s7ok4uw	4521	34	docking	docking	NN
cord-001835-0s7ok4uw	4521	35	scheme	scheme	NN
cord-001835-0s7ok4uw	4521	36	.	.	.
cord-001835-0s7ok4uw	4522	1	5	5	LS
cord-001835-0s7ok4uw	4523	1	The	the	DT
cord-001835-0s7ok4uw	4523	2	results	result	NNS
cord-001835-0s7ok4uw	4523	3	show	show	VBP
cord-001835-0s7ok4uw	4523	4	that	that	IN
cord-001835-0s7ok4uw	4523	5	considering	consider	VBG
cord-001835-0s7ok4uw	4523	6	conformational	conformational	JJ
cord-001835-0s7ok4uw	4523	7	heterogeneity	heterogeneity	NN
cord-001835-0s7ok4uw	4523	8	of	of	IN
cord-001835-0s7ok4uw	4523	9	interacting	interact	VBG
cord-001835-0s7ok4uw	4523	10	proteins	protein	NNS
cord-001835-0s7ok4uw	4523	11	can	can	MD
cord-001835-0s7ok4uw	4523	12	improve	improve	VB
cord-001835-0s7ok4uw	4523	13	docking	docking	NN
cord-001835-0s7ok4uw	4523	14	description	description	NN
cord-001835-0s7ok4uw	4523	15	in	in	IN
cord-001835-0s7ok4uw	4523	16	cases	case	NNS
cord-001835-0s7ok4uw	4523	17	that	that	WDT
cord-001835-0s7ok4uw	4523	18	involve	involve	VBP
cord-001835-0s7ok4uw	4523	19	intermediate	intermediate	JJ
cord-001835-0s7ok4uw	4523	20	conformational	conformational	JJ
cord-001835-0s7ok4uw	4523	21	changes	change	NNS
cord-001835-0s7ok4uw	4523	22	in	in	IN
cord-001835-0s7ok4uw	4523	23	the	the	DT
cord-001835-0s7ok4uw	4523	24	unbound	unbound	JJ
cord-001835-0s7ok4uw	4523	25	-	-	HYPH
cord-001835-0s7ok4uw	4523	26	to	to	IN
cord-001835-0s7ok4uw	4523	27	-	-	HYPH
cord-001835-0s7ok4uw	4523	28	bound	bind	VBN
cord-001835-0s7ok4uw	4523	29	transition	transition	NN
cord-001835-0s7ok4uw	4523	30	.	.	.
cord-001835-0s7ok4uw	4524	1	More	more	RBR
cord-001835-0s7ok4uw	4524	2	interestingly	interestingly	RB
cord-001835-0s7ok4uw	4524	3	,	,	,
cord-001835-0s7ok4uw	4524	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	4524	5	found	find	VBD
cord-001835-0s7ok4uw	4524	6	that	that	IN
cord-001835-0s7ok4uw	4524	7	protein	protein	NN
cord-001835-0s7ok4uw	4524	8	plasticity	plasticity	NN
cord-001835-0s7ok4uw	4524	9	increases	increase	VBZ
cord-001835-0s7ok4uw	4524	10	chances	chance	NNS
cord-001835-0s7ok4uw	4524	11	of	of	IN
cord-001835-0s7ok4uw	4524	12	finding	find	VBG
cord-001835-0s7ok4uw	4524	13	conformations	conformation	NNS
cord-001835-0s7ok4uw	4524	14	with	with	IN
cord-001835-0s7ok4uw	4524	15	better	well	RBR
cord-001835-0s7ok4uw	4524	16	binding	bind	VBG
cord-001835-0s7ok4uw	4524	17	energy	energy	NN
cord-001835-0s7ok4uw	4524	18	,	,	,
cord-001835-0s7ok4uw	4524	19	not	not	RB
cord-001835-0s7ok4uw	4524	20	necessarily	necessarily	RB
cord-001835-0s7ok4uw	4524	21	related	relate	VBN
cord-001835-0s7ok4uw	4524	22	to	to	IN
cord-001835-0s7ok4uw	4524	23	bound	bind	VBN
cord-001835-0s7ok4uw	4524	24	geometries	geometry	NNS
cord-001835-0s7ok4uw	4524	25	.	.	.
cord-001835-0s7ok4uw	4525	1	The	the	DT
cord-001835-0s7ok4uw	4525	2	relevance	relevance	NN
cord-001835-0s7ok4uw	4525	3	for	for	IN
cord-001835-0s7ok4uw	4525	4	future	future	JJ
cord-001835-0s7ok4uw	4525	5	docking	docking	NN
cord-001835-0s7ok4uw	4525	6	methodology	methodology	NN
cord-001835-0s7ok4uw	4525	7	development	development	NN
cord-001835-0s7ok4uw	4525	8	and	and	CC
cord-001835-0s7ok4uw	4525	9	for	for	IN
cord-001835-0s7ok4uw	4525	10	understanding	understand	VBG
cord-001835-0s7ok4uw	4525	11	protein	protein	NNP
cord-001835-0s7ok4uw	4525	12	association	association	NNP
cord-001835-0s7ok4uw	4525	13	mechanism	mechanism	NN
cord-001835-0s7ok4uw	4525	14	will	will	MD
cord-001835-0s7ok4uw	4525	15	be	be	VB
cord-001835-0s7ok4uw	4525	16	discussed	discuss	VBN
cord-001835-0s7ok4uw	4525	17	.	.	.
cord-001835-0s7ok4uw	4526	1	Purpose	purpose	NN
cord-001835-0s7ok4uw	4526	2	of	of	IN
cord-001835-0s7ok4uw	4526	3	the	the	DT
cord-001835-0s7ok4uw	4526	4	research	research	NN
cord-001835-0s7ok4uw	4526	5	:	:	:
cord-001835-0s7ok4uw	4526	6	There	there	EX
cord-001835-0s7ok4uw	4526	7	is	be	VBZ
cord-001835-0s7ok4uw	4526	8	increasing	increase	VBG
cord-001835-0s7ok4uw	4526	9	interest	interest	NN
cord-001835-0s7ok4uw	4526	10	in	in	IN
cord-001835-0s7ok4uw	4526	11	the	the	DT
cord-001835-0s7ok4uw	4526	12	development	development	NN
cord-001835-0s7ok4uw	4526	13	of	of	IN
cord-001835-0s7ok4uw	4526	14	protein	protein	NN
cord-001835-0s7ok4uw	4526	15	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	4526	16	that	that	WDT
cord-001835-0s7ok4uw	4526	17	can	can	MD
cord-001835-0s7ok4uw	4526	18	be	be	VB
cord-001835-0s7ok4uw	4526	19	used	use	VBN
cord-001835-0s7ok4uw	4526	20	to	to	TO
cord-001835-0s7ok4uw	4526	21	develop	develop	VB
cord-001835-0s7ok4uw	4526	22	affinity	affinity	NN
cord-001835-0s7ok4uw	4526	23	reagents	reagent	NNS
cord-001835-0s7ok4uw	4526	24	that	that	WDT
cord-001835-0s7ok4uw	4526	25	are	be	VBP
cord-001835-0s7ok4uw	4526	26	alternatives	alternative	NNS
cord-001835-0s7ok4uw	4526	27	to	to	IN
cord-001835-0s7ok4uw	4526	28	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4526	29	.	.	.
cord-001835-0s7ok4uw	4527	1	The	the	DT
cord-001835-0s7ok4uw	4527	2	Affimer	Affimer	NNP
cord-001835-0s7ok4uw	4527	3	scaffold	scaffold	NN
cord-001835-0s7ok4uw	4527	4	is	be	VBZ
cord-001835-0s7ok4uw	4527	5	based	base	VBN
cord-001835-0s7ok4uw	4527	6	on	on	IN
cord-001835-0s7ok4uw	4527	7	the	the	DT
cord-001835-0s7ok4uw	4527	8	cystatin	cystatin	NN
cord-001835-0s7ok4uw	4527	9	protein	protein	NN
cord-001835-0s7ok4uw	4527	10	fold	fold	RB
cord-001835-0s7ok4uw	4527	11	.	.	.
cord-001835-0s7ok4uw	4528	1	The	the	DT
cord-001835-0s7ok4uw	4528	2	Affimer	Affimer	NNP
cord-001835-0s7ok4uw	4528	3	scaffold	scaffold	NN
cord-001835-0s7ok4uw	4528	4	is	be	VBZ
cord-001835-0s7ok4uw	4528	5	biologically	biologically	RB
cord-001835-0s7ok4uw	4528	6	inert	inert	JJ
cord-001835-0s7ok4uw	4528	7	,	,	,
cord-001835-0s7ok4uw	4528	8	biophysically	biophysically	RB
cord-001835-0s7ok4uw	4528	9	stable	stable	JJ
cord-001835-0s7ok4uw	4528	10	and	and	CC
cord-001835-0s7ok4uw	4528	11	capable	capable	JJ
cord-001835-0s7ok4uw	4528	12	of	of	IN
cord-001835-0s7ok4uw	4528	13	presenting	present	VBG
cord-001835-0s7ok4uw	4528	14	a	a	DT
cord-001835-0s7ok4uw	4528	15	range	range	NN
cord-001835-0s7ok4uw	4528	16	of	of	IN
cord-001835-0s7ok4uw	4528	17	designed	design	VBN
cord-001835-0s7ok4uw	4528	18	or	or	CC
cord-001835-0s7ok4uw	4528	19	random	random	JJ
cord-001835-0s7ok4uw	4528	20	binding	binding	JJ
cord-001835-0s7ok4uw	4528	21	surfaces	surface	NNS
cord-001835-0s7ok4uw	4528	22	defined	define	VBN
cord-001835-0s7ok4uw	4528	23	by	by	IN
cord-001835-0s7ok4uw	4528	24	peptides	peptide	NNS
cord-001835-0s7ok4uw	4528	25	inserted	insert	VBN
cord-001835-0s7ok4uw	4528	26	at	at	IN
cord-001835-0s7ok4uw	4528	27	2	2	CD
cord-001835-0s7ok4uw	4528	28	different	different	JJ
cord-001835-0s7ok4uw	4528	29	loops	loop	NNS
cord-001835-0s7ok4uw	4528	30	.	.	.
cord-001835-0s7ok4uw	4529	1	The	the	DT
cord-001835-0s7ok4uw	4529	2	result	result	NN
cord-001835-0s7ok4uw	4529	3	is	be	VBZ
cord-001835-0s7ok4uw	4529	4	highly	highly	RB
cord-001835-0s7ok4uw	4529	5	specific	specific	JJ
cord-001835-0s7ok4uw	4529	6	,	,	,
cord-001835-0s7ok4uw	4529	7	high	high	JJ
cord-001835-0s7ok4uw	4529	8	affinity	affinity	NN
cord-001835-0s7ok4uw	4529	9	interactions	interaction	NNS
cord-001835-0s7ok4uw	4529	10	with	with	IN
cord-001835-0s7ok4uw	4529	11	a	a	DT
cord-001835-0s7ok4uw	4529	12	wide	wide	JJ
cord-001835-0s7ok4uw	4529	13	range	range	NN
cord-001835-0s7ok4uw	4529	14	of	of	IN
cord-001835-0s7ok4uw	4529	15	targets	target	NNS
cord-001835-0s7ok4uw	4529	16	including	include	VBG
cord-001835-0s7ok4uw	4529	17	ones	one	NNS
cord-001835-0s7ok4uw	4529	18	that	that	WDT
cord-001835-0s7ok4uw	4529	19	are	be	VBP
cord-001835-0s7ok4uw	4529	20	inaccessible	inaccessible	JJ
cord-001835-0s7ok4uw	4529	21	to	to	IN
cord-001835-0s7ok4uw	4529	22	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4529	23	.	.	.
cord-001835-0s7ok4uw	4530	1	Affimers	affimer	NNS
cord-001835-0s7ok4uw	4530	2	are	be	VBP
cord-001835-0s7ok4uw	4530	3	designed	design	VBN
cord-001835-0s7ok4uw	4530	4	to	to	TO
cord-001835-0s7ok4uw	4530	5	work	work	VB
cord-001835-0s7ok4uw	4530	6	in	in	IN
cord-001835-0s7ok4uw	4530	7	the	the	DT
cord-001835-0s7ok4uw	4530	8	same	same	JJ
cord-001835-0s7ok4uw	4530	9	way	way	NN
cord-001835-0s7ok4uw	4530	10	as	as	IN
cord-001835-0s7ok4uw	4530	11	the	the	DT
cord-001835-0s7ok4uw	4530	12	very	very	RB
cord-001835-0s7ok4uw	4530	13	best	good	JJS
cord-001835-0s7ok4uw	4530	14	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4530	15	,	,	,
cord-001835-0s7ok4uw	4530	16	but	but	CC
cord-001835-0s7ok4uw	4530	17	with	with	IN
cord-001835-0s7ok4uw	4530	18	a	a	DT
cord-001835-0s7ok4uw	4530	19	number	number	NN
cord-001835-0s7ok4uw	4530	20	of	of	IN
cord-001835-0s7ok4uw	4530	21	key	key	JJ
cord-001835-0s7ok4uw	4530	22	advantages	advantage	NNS
cord-001835-0s7ok4uw	4530	23	.	.	.
cord-001835-0s7ok4uw	4531	1	Affimers	affimer	NNS
cord-001835-0s7ok4uw	4531	2	are	be	VBP
cord-001835-0s7ok4uw	4531	3	quick	quick	JJ
cord-001835-0s7ok4uw	4531	4	to	to	TO
cord-001835-0s7ok4uw	4531	5	develop	develop	VB
cord-001835-0s7ok4uw	4531	6	(	(	-LRB-
cord-001835-0s7ok4uw	4531	7	typically	typically	RB
cord-001835-0s7ok4uw	4531	8	7	7	CD
cord-001835-0s7ok4uw	4531	9	weeks	week	NNS
cord-001835-0s7ok4uw	4531	10	)	)	-RRB-
cord-001835-0s7ok4uw	4531	11	without	without	IN
cord-001835-0s7ok4uw	4531	12	using	use	VBG
cord-001835-0s7ok4uw	4531	13	animals	animal	NNS
cord-001835-0s7ok4uw	4531	14	.	.	.
cord-001835-0s7ok4uw	4532	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	4532	2	contain	contain	VBP
cord-001835-0s7ok4uw	4532	3	no	no	DT
cord-001835-0s7ok4uw	4532	4	disulphide	disulphide	JJ
cord-001835-0s7ok4uw	4532	5	bonds	bond	NNS
cord-001835-0s7ok4uw	4532	6	,	,	,
cord-001835-0s7ok4uw	4532	7	are	be	VBP
cord-001835-0s7ok4uw	4532	8	expressed	express	VBN
cord-001835-0s7ok4uw	4532	9	easily	easily	RB
cord-001835-0s7ok4uw	4532	10	in	in	IN
cord-001835-0s7ok4uw	4532	11	E.	E.	NNP
cord-001835-0s7ok4uw	4532	12	coli	coli	NNS
cord-001835-0s7ok4uw	4532	13	and	and	CC
cord-001835-0s7ok4uw	4532	14	have	have	VBP
cord-001835-0s7ok4uw	4532	15	no	no	DT
cord-001835-0s7ok4uw	4532	16	batch	batch	NN
cord-001835-0s7ok4uw	4532	17	to	to	TO
cord-001835-0s7ok4uw	4532	18	batch	batch	VB
cord-001835-0s7ok4uw	4532	19	variability	variability	NN
cord-001835-0s7ok4uw	4532	20	.	.	.
cord-001835-0s7ok4uw	4533	1	Affimers	affimer	NNS
cord-001835-0s7ok4uw	4533	2	are	be	VBP
cord-001835-0s7ok4uw	4533	3	small	small	JJ
cord-001835-0s7ok4uw	4533	4	molecules	molecule	NNS
cord-001835-0s7ok4uw	4533	5	(	(	-LRB-
cord-001835-0s7ok4uw	4533	6	108	108	CD
cord-001835-0s7ok4uw	4533	7	aa	aa	NNP
cord-001835-0s7ok4uw	4533	8	,	,	,
cord-001835-0s7ok4uw	4533	9	12	12	CD
cord-001835-0s7ok4uw	4533	10	kDa	kDa	NNPS
cord-001835-0s7ok4uw	4533	11	)	)	-RRB-
cord-001835-0s7ok4uw	4533	12	,	,	,
cord-001835-0s7ok4uw	4533	13	robust	robust	JJ
cord-001835-0s7ok4uw	4533	14	and	and	CC
cord-001835-0s7ok4uw	4533	15	stable	stable	JJ
cord-001835-0s7ok4uw	4533	16	(	(	-LRB-
cord-001835-0s7ok4uw	4533	17	resistant	resistant	JJ
cord-001835-0s7ok4uw	4533	18	to	to	IN
cord-001835-0s7ok4uw	4533	19	pH	ph	NN
cord-001835-0s7ok4uw	4533	20	range	range	NN
cord-001835-0s7ok4uw	4533	21	,	,	,
cord-001835-0s7ok4uw	4533	22	thermally	thermally	RB
cord-001835-0s7ok4uw	4533	23	stable	stable	JJ
cord-001835-0s7ok4uw	4533	24	and	and	CC
cord-001835-0s7ok4uw	4533	25	not	not	RB
cord-001835-0s7ok4uw	4533	26	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	4533	27	to	to	IN
cord-001835-0s7ok4uw	4533	28	EDTA	EDTA	NNP
cord-001835-0s7ok4uw	4533	29	)	)	-RRB-
cord-001835-0s7ok4uw	4533	30	.	.	.
cord-001835-0s7ok4uw	4534	1	Affimers	affimer	NNS
cord-001835-0s7ok4uw	4534	2	can	can	MD
cord-001835-0s7ok4uw	4534	3	be	be	VB
cord-001835-0s7ok4uw	4534	4	a	a	DT
cord-001835-0s7ok4uw	4534	5	direct	direct	JJ
cord-001835-0s7ok4uw	4534	6	replacement	replacement	NN
cord-001835-0s7ok4uw	4534	7	for	for	IN
cord-001835-0s7ok4uw	4534	8	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4534	9	-no	-no	:
cord-001835-0s7ok4uw	4534	10	process	process	NN
cord-001835-0s7ok4uw	4534	11	or	or	CC
cord-001835-0s7ok4uw	4534	12	workflow	workflow	NN
cord-001835-0s7ok4uw	4534	13	change	change	NN
cord-001835-0s7ok4uw	4534	14	required	require	VBD
cord-001835-0s7ok4uw	4534	15	-and	-and	:
cord-001835-0s7ok4uw	4534	16	perform	perform	VB
cord-001835-0s7ok4uw	4534	17	identically	identically	RB
cord-001835-0s7ok4uw	4534	18	to	to	IN
cord-001835-0s7ok4uw	4534	19	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4534	20	in	in	IN
cord-001835-0s7ok4uw	4534	21	assays	assay	NNS
cord-001835-0s7ok4uw	4534	22	such	such	JJ
cord-001835-0s7ok4uw	4534	23	as	as	IN
cord-001835-0s7ok4uw	4534	24	ELISA	ELISA	NNP
cord-001835-0s7ok4uw	4534	25	,	,	,
cord-001835-0s7ok4uw	4534	26	FACS	FACS	NNP
cord-001835-0s7ok4uw	4534	27	,	,	,
cord-001835-0s7ok4uw	4534	28	IHC	IHC	NNP
cord-001835-0s7ok4uw	4534	29	,	,	,
cord-001835-0s7ok4uw	4534	30	western	western	JJ
cord-001835-0s7ok4uw	4534	31	blots	blot	NNS
cord-001835-0s7ok4uw	4534	32	,	,	,
cord-001835-0s7ok4uw	4534	33	affinity	affinity	NN
cord-001835-0s7ok4uw	4534	34	purification	purification	NN
cord-001835-0s7ok4uw	4534	35	,	,	,
cord-001835-0s7ok4uw	4534	36	microarray	microarray	NN
cord-001835-0s7ok4uw	4534	37	and	and	CC
cord-001835-0s7ok4uw	4534	38	potentially	potentially	RB
cord-001835-0s7ok4uw	4534	39	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	4534	40	.	.	.
cord-001835-0s7ok4uw	4535	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4535	2	describe	describe	VBP
cord-001835-0s7ok4uw	4535	3	some	some	DT
cord-001835-0s7ok4uw	4535	4	applications	application	NNS
cord-001835-0s7ok4uw	4535	5	of	of	IN
cord-001835-0s7ok4uw	4535	6	the	the	DT
cord-001835-0s7ok4uw	4535	7	technology	technology	NN
cord-001835-0s7ok4uw	4535	8	in	in	IN
cord-001835-0s7ok4uw	4535	9	regards	regard	NNS
cord-001835-0s7ok4uw	4535	10	of	of	IN
cord-001835-0s7ok4uw	4535	11	Affimer	Affimer	NNP
cord-001835-0s7ok4uw	4535	12	development	development	NN
cord-001835-0s7ok4uw	4535	13	for	for	IN
cord-001835-0s7ok4uw	4535	14	custom	custom	NN
cord-001835-0s7ok4uw	4535	15	targets	target	NNS
cord-001835-0s7ok4uw	4535	16	on	on	IN
cord-001835-0s7ok4uw	4535	17	one	one	CD
cord-001835-0s7ok4uw	4535	18	hand	hand	NN
cord-001835-0s7ok4uw	4535	19	and	and	CC
cord-001835-0s7ok4uw	4535	20	for	for	IN
cord-001835-0s7ok4uw	4535	21	the	the	DT
cord-001835-0s7ok4uw	4535	22	biomarker	biomarker	NN
cord-001835-0s7ok4uw	4535	23	discovery	discovery	NN
cord-001835-0s7ok4uw	4535	24	workflow	workflow	NN
cord-001835-0s7ok4uw	4535	25	using	use	VBG
cord-001835-0s7ok4uw	4535	26	Affimer	Affimer	NNP
cord-001835-0s7ok4uw	4535	27	microarrays	microarray	NNS
cord-001835-0s7ok4uw	4535	28	on	on	IN
cord-001835-0s7ok4uw	4535	29	the	the	DT
cord-001835-0s7ok4uw	4535	30	other	other	JJ
cord-001835-0s7ok4uw	4535	31	.	.	.
cord-001835-0s7ok4uw	4536	1	Main	main	JJ
cord-001835-0s7ok4uw	4536	2	results	result	NNS
cord-001835-0s7ok4uw	4536	3	:	:	:
cord-001835-0s7ok4uw	4536	4	By	by	IN
cord-001835-0s7ok4uw	4536	5	screening	screening	NN
cord-001835-0s7ok4uw	4536	6	of	of	IN
cord-001835-0s7ok4uw	4536	7	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4536	8	very	very	RB
cord-001835-0s7ok4uw	4536	9	large	large	JJ
cord-001835-0s7ok4uw	4536	10	(	(	-LRB-
cord-001835-0s7ok4uw	4536	11	3	3	CD
cord-001835-0s7ok4uw	4536	12	x	x	SYM
cord-001835-0s7ok4uw	4536	13	1010	1010	CD
cord-001835-0s7ok4uw	4536	14	)	)	-RRB-
cord-001835-0s7ok4uw	4536	15	library	library	NN
cord-001835-0s7ok4uw	4536	16	against	against	IN
cord-001835-0s7ok4uw	4536	17	Yeast	Yeast	NNP
cord-001835-0s7ok4uw	4536	18	SUMO	SUMO	NNP
cord-001835-0s7ok4uw	4536	19	protein	protein	NN
cord-001835-0s7ok4uw	4536	20	we	-PRON-	PRP
cord-001835-0s7ok4uw	4536	21	identified	identify	VBD
cord-001835-0s7ok4uw	4536	22	Affimers	Affimers	NNPS
cord-001835-0s7ok4uw	4536	23	with	with	IN
cord-001835-0s7ok4uw	4536	24	high	high	JJ
cord-001835-0s7ok4uw	4536	25	affinity	affinity	NN
cord-001835-0s7ok4uw	4536	26	allowing	allow	VBG
cord-001835-0s7ok4uw	4536	27	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4536	28	use	use	NN
cord-001835-0s7ok4uw	4536	29	for	for	IN
cord-001835-0s7ok4uw	4536	30	ELISA	ELISA	NNP
cord-001835-0s7ok4uw	4536	31	.	.	.
cord-001835-0s7ok4uw	4537	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	4537	2	,	,	,
cord-001835-0s7ok4uw	4537	3	no	no	DT
cord-001835-0s7ok4uw	4537	4	cross	cross	NN
cord-001835-0s7ok4uw	4537	5	-	-	NN
cord-001835-0s7ok4uw	4537	6	reactivity	reactivity	NN
cord-001835-0s7ok4uw	4537	7	was	be	VBD
cord-001835-0s7ok4uw	4537	8	observed	observe	VBN
cord-001835-0s7ok4uw	4537	9	when	when	WRB
cord-001835-0s7ok4uw	4537	10	Affimers	Affimers	NNPS
cord-001835-0s7ok4uw	4537	11	were	be	VBD
cord-001835-0s7ok4uw	4537	12	used	use	VBN
cord-001835-0s7ok4uw	4537	13	on	on	IN
cord-001835-0s7ok4uw	4537	14	western	western	JJ
cord-001835-0s7ok4uw	4537	15	blots	blot	NNS
cord-001835-0s7ok4uw	4537	16	leading	lead	VBG
cord-001835-0s7ok4uw	4537	17	to	to	IN
cord-001835-0s7ok4uw	4537	18	a	a	DT
cord-001835-0s7ok4uw	4537	19	unique	unique	JJ
cord-001835-0s7ok4uw	4537	20	band	band	NN
cord-001835-0s7ok4uw	4537	21	specific	specific	JJ
cord-001835-0s7ok4uw	4537	22	to	to	IN
cord-001835-0s7ok4uw	4537	23	Yeast	Yeast	NNP
cord-001835-0s7ok4uw	4537	24	SUMO	SUMO	NNP
cord-001835-0s7ok4uw	4537	25	when	when	WRB
cord-001835-0s7ok4uw	4537	26	compared	compare	VBN
cord-001835-0s7ok4uw	4537	27	to	to	IN
cord-001835-0s7ok4uw	4537	28	human	human	JJ
cord-001835-0s7ok4uw	4537	29	proteins	protein	NNS
cord-001835-0s7ok4uw	4537	30	.	.	.
cord-001835-0s7ok4uw	4538	1	A	a	DT
cord-001835-0s7ok4uw	4538	2	library	library	NN
cord-001835-0s7ok4uw	4538	3	of	of	IN
cord-001835-0s7ok4uw	4538	4	25,000	25,000	CD
cord-001835-0s7ok4uw	4538	5	random	random	JJ
cord-001835-0s7ok4uw	4538	6	Affimers	Affimers	NNPS
cord-001835-0s7ok4uw	4538	7	,	,	,
cord-001835-0s7ok4uw	4538	8	expressed	express	VBN
cord-001835-0s7ok4uw	4538	9	in	in	IN
cord-001835-0s7ok4uw	4538	10	E.	E.	NNP
cord-001835-0s7ok4uw	4538	11	coli	coli	NNS
cord-001835-0s7ok4uw	4538	12	,	,	,
cord-001835-0s7ok4uw	4538	13	was	be	VBD
cord-001835-0s7ok4uw	4538	14	printed	print	VBN
cord-001835-0s7ok4uw	4538	15	on	on	IN
cord-001835-0s7ok4uw	4538	16	glass	glass	NN
cord-001835-0s7ok4uw	4538	17	microscope	microscope	NN
cord-001835-0s7ok4uw	4538	18	slides	slide	NNS
cord-001835-0s7ok4uw	4538	19	and	and	CC
cord-001835-0s7ok4uw	4538	20	challenged	challenge	VBN
cord-001835-0s7ok4uw	4538	21	with	with	IN
cord-001835-0s7ok4uw	4538	22	plasma	plasma	NN
cord-001835-0s7ok4uw	4538	23	from	from	IN
cord-001835-0s7ok4uw	4538	24	children	child	NNS
cord-001835-0s7ok4uw	4538	25	(	(	-LRB-
cord-001835-0s7ok4uw	4538	26	n5104	n5104	NNP
cord-001835-0s7ok4uw	4538	27	)	)	-RRB-
cord-001835-0s7ok4uw	4538	28	with	with	IN
cord-001835-0s7ok4uw	4538	29	sepsis	sepsis	NN
cord-001835-0s7ok4uw	4538	30	and	and	CC
cord-001835-0s7ok4uw	4538	31	from	from	IN
cord-001835-0s7ok4uw	4538	32	healthy	healthy	JJ
cord-001835-0s7ok4uw	4538	33	children	child	NNS
cord-001835-0s7ok4uw	4538	34	(	(	-LRB-
cord-001835-0s7ok4uw	4538	35	n524	n524	NNP
cord-001835-0s7ok4uw	4538	36	)	)	-RRB-
cord-001835-0s7ok4uw	4538	37	.	.	.
cord-001835-0s7ok4uw	4539	1	Unsupervised	unsupervised	JJ
cord-001835-0s7ok4uw	4539	2	hierarchical	hierarchical	JJ
cord-001835-0s7ok4uw	4539	3	clustering	clustering	NN
cord-001835-0s7ok4uw	4539	4	based	base	VBN
cord-001835-0s7ok4uw	4539	5	on	on	IN
cord-001835-0s7ok4uw	4539	6	the	the	DT
cord-001835-0s7ok4uw	4539	7	25,000	25,000	CD
cord-001835-0s7ok4uw	4539	8	Affimers	Affimers	NNPS
cord-001835-0s7ok4uw	4539	9	allowed	allow	VBD
cord-001835-0s7ok4uw	4539	10	differentiation	differentiation	NN
cord-001835-0s7ok4uw	4539	11	between	between	IN
cord-001835-0s7ok4uw	4539	12	the	the	DT
cord-001835-0s7ok4uw	4539	13	control	control	NN
cord-001835-0s7ok4uw	4539	14	and	and	CC
cord-001835-0s7ok4uw	4539	15	patient	patient	NN
cord-001835-0s7ok4uw	4539	16	samples	sample	NNS
cord-001835-0s7ok4uw	4539	17	.	.	.
cord-001835-0s7ok4uw	4540	1	200	200	CD
cord-001835-0s7ok4uw	4540	2	Affimers	Affimers	NNPS
cord-001835-0s7ok4uw	4540	3	were	be	VBD
cord-001835-0s7ok4uw	4540	4	found	find	VBN
cord-001835-0s7ok4uw	4540	5	to	to	TO
cord-001835-0s7ok4uw	4540	6	differentially	differentially	RB
cord-001835-0s7ok4uw	4540	7	bind	bind	VB
cord-001835-0s7ok4uw	4540	8	proteins	protein	NNS
cord-001835-0s7ok4uw	4540	9	between	between	IN
cord-001835-0s7ok4uw	4540	10	the	the	DT
cord-001835-0s7ok4uw	4540	11	2	2	CD
cord-001835-0s7ok4uw	4540	12	groups	group	NNS
cord-001835-0s7ok4uw	4540	13	with	with	IN
cord-001835-0s7ok4uw	4540	14	a	a	DT
cord-001835-0s7ok4uw	4540	15	>	>	XX
cord-001835-0s7ok4uw	4540	16	2	2	CD
cord-001835-0s7ok4uw	4540	17	fold	fold	JJ
cord-001835-0s7ok4uw	4540	18	change	change	NN
cord-001835-0s7ok4uw	4540	19	.	.	.
cord-001835-0s7ok4uw	4541	1	The	the	DT
cord-001835-0s7ok4uw	4541	2	Affimer	Affimer	NNP
cord-001835-0s7ok4uw	4541	3	arrays	array	NNS
cord-001835-0s7ok4uw	4541	4	identified	identify	VBD
cord-001835-0s7ok4uw	4541	5	a	a	DT
cord-001835-0s7ok4uw	4541	6	strong	strong	JJ
cord-001835-0s7ok4uw	4541	7	signature	signature	NN
cord-001835-0s7ok4uw	4541	8	of	of	IN
cord-001835-0s7ok4uw	4541	9	sepsis	sepsis	NN
cord-001835-0s7ok4uw	4541	10	and	and	CC
cord-001835-0s7ok4uw	4541	11	ROC	ROC	NNP
cord-001835-0s7ok4uw	4541	12	curve	curve	NN
cord-001835-0s7ok4uw	4541	13	analysis	analysis	NN
cord-001835-0s7ok4uw	4541	14	allowed	allow	VBD
cord-001835-0s7ok4uw	4541	15	confident	confident	JJ
cord-001835-0s7ok4uw	4541	16	prediction	prediction	NN
cord-001835-0s7ok4uw	4541	17	of	of	IN
cord-001835-0s7ok4uw	4541	18	disease	disease	NN
cord-001835-0s7ok4uw	4541	19	(	(	-LRB-
cord-001835-0s7ok4uw	4541	20	AUROC	AUROC	NNP
cord-001835-0s7ok4uw	4541	21	of	of	IN
cord-001835-0s7ok4uw	4541	22	0.9	0.9	CD
cord-001835-0s7ok4uw	4541	23	)	)	-RRB-
cord-001835-0s7ok4uw	4541	24	.	.	.
cord-001835-0s7ok4uw	4542	1	Affinity	affinity	NN
cord-001835-0s7ok4uw	4542	2	purification	purification	NN
cord-001835-0s7ok4uw	4542	3	and	and	CC
cord-001835-0s7ok4uw	4542	4	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	4542	5	mass	mass	NN
cord-001835-0s7ok4uw	4542	6	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4542	7	analysis	analysis	NN
cord-001835-0s7ok4uw	4542	8	identified	identify	VBD
cord-001835-0s7ok4uw	4542	9	known	know	VBN
cord-001835-0s7ok4uw	4542	10	biomarkers	biomarker	NNS
cord-001835-0s7ok4uw	4542	11	of	of	IN
cord-001835-0s7ok4uw	4542	12	sepsis	sepsis	NN
cord-001835-0s7ok4uw	4542	13	and	and	CC
cord-001835-0s7ok4uw	4542	14	also	also	RB
cord-001835-0s7ok4uw	4542	15	potentially	potentially	RB
cord-001835-0s7ok4uw	4542	16	novel	novel	JJ
cord-001835-0s7ok4uw	4542	17	biomarkers	biomarker	NNS
cord-001835-0s7ok4uw	4542	18	not	not	RB
cord-001835-0s7ok4uw	4542	19	previously	previously	RB
cord-001835-0s7ok4uw	4542	20	associated	associate	VBN
cord-001835-0s7ok4uw	4542	21	with	with	IN
cord-001835-0s7ok4uw	4542	22	this	this	DT
cord-001835-0s7ok4uw	4542	23	disease	disease	NN
cord-001835-0s7ok4uw	4542	24	.	.	.
cord-001835-0s7ok4uw	4543	1	Major	major	JJ
cord-001835-0s7ok4uw	4543	2	conclusions	conclusion	NNS
cord-001835-0s7ok4uw	4543	3	:	:	:
cord-001835-0s7ok4uw	4544	1	This	this	DT
cord-001835-0s7ok4uw	4544	2	work	work	NN
cord-001835-0s7ok4uw	4544	3	demonstrates	demonstrate	VBZ
cord-001835-0s7ok4uw	4544	4	the	the	DT
cord-001835-0s7ok4uw	4544	5	scope	scope	NN
cord-001835-0s7ok4uw	4544	6	of	of	IN
cord-001835-0s7ok4uw	4544	7	Affimer	Affimer	NNP
cord-001835-0s7ok4uw	4544	8	affinity	affinity	NN
cord-001835-0s7ok4uw	4544	9	reagents	reagent	NNS
cord-001835-0s7ok4uw	4544	10	to	to	TO
cord-001835-0s7ok4uw	4544	11	develop	develop	VB
cord-001835-0s7ok4uw	4544	12	alternative	alternative	JJ
cord-001835-0s7ok4uw	4544	13	binders	binder	NNS
cord-001835-0s7ok4uw	4544	14	to	to	IN
cord-001835-0s7ok4uw	4544	15	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4544	16	,	,	,
cord-001835-0s7ok4uw	4544	17	where	where	WRB
cord-001835-0s7ok4uw	4544	18	Affimers	Affimers	NNPS
cord-001835-0s7ok4uw	4544	19	perform	perform	VBP
cord-001835-0s7ok4uw	4544	20	identically	identically	RB
cord-001835-0s7ok4uw	4544	21	in	in	IN
cord-001835-0s7ok4uw	4544	22	most	most	JJS
cord-001835-0s7ok4uw	4544	23	assays	assay	NNS
cord-001835-0s7ok4uw	4544	24	without	without	IN
cord-001835-0s7ok4uw	4544	25	the	the	DT
cord-001835-0s7ok4uw	4544	26	disadvantages	disadvantage	NNS
cord-001835-0s7ok4uw	4544	27	associated	associate	VBN
cord-001835-0s7ok4uw	4544	28	with	with	IN
cord-001835-0s7ok4uw	4544	29	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4544	30	.	.	.
cord-001835-0s7ok4uw	4545	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	4545	2	,	,	,
cord-001835-0s7ok4uw	4545	3	Affimers	Affimers	NNPS
cord-001835-0s7ok4uw	4545	4	enable	enable	VBP
cord-001835-0s7ok4uw	4545	5	a	a	DT
cord-001835-0s7ok4uw	4545	6	new	new	JJ
cord-001835-0s7ok4uw	4545	7	protein	protein	NN
cord-001835-0s7ok4uw	4545	8	microarray	microarray	NN
cord-001835-0s7ok4uw	4545	9	-	-	HYPH
cord-001835-0s7ok4uw	4545	10	based	base	VBN
cord-001835-0s7ok4uw	4545	11	biomarker	biomarker	NN
cord-001835-0s7ok4uw	4545	12	-	-	HYPH
cord-001835-0s7ok4uw	4545	13	discovery	discovery	NN
cord-001835-0s7ok4uw	4545	14	workflow	workflow	NN
cord-001835-0s7ok4uw	4545	15	and	and	CC
cord-001835-0s7ok4uw	4545	16	we	-PRON-	PRP
cord-001835-0s7ok4uw	4545	17	predict	predict	VBP
cord-001835-0s7ok4uw	4545	18	that	that	IN
cord-001835-0s7ok4uw	4545	19	array	array	NN
cord-001835-0s7ok4uw	4545	20	-	-	HYPH
cord-001835-0s7ok4uw	4545	21	based	base	VBN
cord-001835-0s7ok4uw	4545	22	validation	validation	NN
cord-001835-0s7ok4uw	4545	23	of	of	IN
cord-001835-0s7ok4uw	4545	24	signatures	signature	NNS
cord-001835-0s7ok4uw	4545	25	identified	identify	VBN
cord-001835-0s7ok4uw	4545	26	using	use	VBG
cord-001835-0s7ok4uw	4545	27	Discovery	Discovery	NNP
cord-001835-0s7ok4uw	4545	28	Arrays	Arrays	NNPS
cord-001835-0s7ok4uw	4545	29	prior	prior	RB
cord-001835-0s7ok4uw	4545	30	to	to	IN
cord-001835-0s7ok4uw	4545	31	affinity	affinity	NN
cord-001835-0s7ok4uw	4545	32	purification	purification	NN
cord-001835-0s7ok4uw	4545	33	and	and	CC
cord-001835-0s7ok4uw	4545	34	mass	mass	NN
cord-001835-0s7ok4uw	4545	35	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4545	36	will	will	MD
cord-001835-0s7ok4uw	4545	37	offer	offer	VB
cord-001835-0s7ok4uw	4545	38	a	a	DT
cord-001835-0s7ok4uw	4545	39	cost	cost	NN
cord-001835-0s7ok4uw	4545	40	-	-	HYPH
cord-001835-0s7ok4uw	4545	41	and	and	CC
cord-001835-0s7ok4uw	4545	42	time	time	NN
cord-001835-0s7ok4uw	4545	43	-	-	HYPH
cord-001835-0s7ok4uw	4545	44	effective	effective	JJ
cord-001835-0s7ok4uw	4545	45	methodology	methodology	NN
cord-001835-0s7ok4uw	4545	46	compared	compare	VBN
cord-001835-0s7ok4uw	4545	47	to	to	IN
cord-001835-0s7ok4uw	4545	48	purely	purely	RB
cord-001835-0s7ok4uw	4545	49	mass	mass	JJ
cord-001835-0s7ok4uw	4545	50	spec	spec	NN
cord-001835-0s7ok4uw	4545	51	-	-	HYPH
cord-001835-0s7ok4uw	4545	52	driven	drive	VBN
cord-001835-0s7ok4uw	4545	53	workflows	workflow	NNS
cord-001835-0s7ok4uw	4545	54	.	.	.
cord-001835-0s7ok4uw	4546	1	Tau	Tau	NNP
cord-001835-0s7ok4uw	4546	2	pathologies	pathology	NNS
cord-001835-0s7ok4uw	4546	3	,	,	,
cord-001835-0s7ok4uw	4546	4	called	call	VBD
cord-001835-0s7ok4uw	4546	5	'	'	``
cord-001835-0s7ok4uw	4546	6	tauopathies	tauopathie	NNS
cord-001835-0s7ok4uw	4546	7	'	'	''
cord-001835-0s7ok4uw	4546	8	,	,	,
cord-001835-0s7ok4uw	4546	9	are	be	VBP
cord-001835-0s7ok4uw	4546	10	related	relate	VBN
cord-001835-0s7ok4uw	4546	11	to	to	IN
cord-001835-0s7ok4uw	4546	12	several	several	JJ
cord-001835-0s7ok4uw	4546	13	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	4546	14	diseases	disease	NNS
cord-001835-0s7ok4uw	4546	15	including	include	VBG
cord-001835-0s7ok4uw	4546	16	Alzheimer	Alzheimer	NNP
cord-001835-0s7ok4uw	4546	17	Disease	Disease	NNP
cord-001835-0s7ok4uw	4546	18	(	(	-LRB-
cord-001835-0s7ok4uw	4546	19	AD	ad	NN
cord-001835-0s7ok4uw	4546	20	)	)	-RRB-
cord-001835-0s7ok4uw	4546	21	.	.	.
cord-001835-0s7ok4uw	4547	1	In	in	IN
cord-001835-0s7ok4uw	4547	2	AD	ad	NN
cord-001835-0s7ok4uw	4547	3	,	,	,
cord-001835-0s7ok4uw	4547	4	Tau	Tau	NNP
cord-001835-0s7ok4uw	4547	5	protein	protein	NN
cord-001835-0s7ok4uw	4547	6	is	be	VBZ
cord-001835-0s7ok4uw	4547	7	observed	observe	VBN
cord-001835-0s7ok4uw	4547	8	hyper	hyper	RB
cord-001835-0s7ok4uw	4547	9	-	-	JJ
cord-001835-0s7ok4uw	4547	10	phosphorylated	phosphorylated	JJ
cord-001835-0s7ok4uw	4547	11	and	and	CC
cord-001835-0s7ok4uw	4547	12	aggregated	aggregate	VBN
cord-001835-0s7ok4uw	4547	13	as	as	IN
cord-001835-0s7ok4uw	4547	14	Paired	Paired	NNP
cord-001835-0s7ok4uw	4547	15	Helical	Helical	NNP
cord-001835-0s7ok4uw	4547	16	Filament	Filament	NNP
cord-001835-0s7ok4uw	4547	17	(	(	-LRB-
cord-001835-0s7ok4uw	4547	18	PHF	PHF	NNP
cord-001835-0s7ok4uw	4547	19	)	)	-RRB-
cord-001835-0s7ok4uw	4547	20	.	.	.
cord-001835-0s7ok4uw	4548	1	The	the	DT
cord-001835-0s7ok4uw	4548	2	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	4548	3	Tau	Tau	NNP
cord-001835-0s7ok4uw	4548	4	protein	protein	NN
cord-001835-0s7ok4uw	4548	5	is	be	VBZ
cord-001835-0s7ok4uw	4548	6	an	an	DT
cord-001835-0s7ok4uw	4548	7	Intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	4548	8	Disordered	disordered	JJ
cord-001835-0s7ok4uw	4548	9	Proteins	protein	NNS
cord-001835-0s7ok4uw	4548	10	(	(	-LRB-
cord-001835-0s7ok4uw	4548	11	IDPs	IDPs	NNP
cord-001835-0s7ok4uw	4548	12	)	)	-RRB-
cord-001835-0s7ok4uw	4548	13	.	.	.
cord-001835-0s7ok4uw	4549	1	Nuclear	Nuclear	NNP
cord-001835-0s7ok4uw	4549	2	Magnetic	magnetic	JJ
cord-001835-0s7ok4uw	4549	3	Resonance	Resonance	NNP
cord-001835-0s7ok4uw	4549	4	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	4549	5	(	(	-LRB-
cord-001835-0s7ok4uw	4549	6	NMR	NMR	NNP
cord-001835-0s7ok4uw	4549	7	)	)	-RRB-
cord-001835-0s7ok4uw	4549	8	is	be	VBZ
cord-001835-0s7ok4uw	4549	9	here	here	RB
cord-001835-0s7ok4uw	4549	10	used	use	VBN
cord-001835-0s7ok4uw	4549	11	to	to	TO
cord-001835-0s7ok4uw	4549	12	study	study	VB
cord-001835-0s7ok4uw	4549	13	the	the	DT
cord-001835-0s7ok4uw	4549	14	Tau	Tau	NNP
cord-001835-0s7ok4uw	4549	15	protein	protein	NN
cord-001835-0s7ok4uw	4549	16	phosphorylations	phosphorylation	NNS
cord-001835-0s7ok4uw	4549	17	and	and	CC
cord-001835-0s7ok4uw	4549	18	Protein	Protein	NNP
cord-001835-0s7ok4uw	4549	19	-	-	HYPH
cord-001835-0s7ok4uw	4549	20	Protein	Protein	NNP
cord-001835-0s7ok4uw	4549	21	Interactions	Interactions	NNPS
cord-001835-0s7ok4uw	4549	22	(	(	-LRB-
cord-001835-0s7ok4uw	4549	23	PPIs	ppi	NNS
cord-001835-0s7ok4uw	4549	24	)	)	-RRB-
cord-001835-0s7ok4uw	4549	25	.	.	.
cord-001835-0s7ok4uw	4550	1	In	in	IN
cord-001835-0s7ok4uw	4550	2	in	in	FW
cord-001835-0s7ok4uw	4550	3	vitro	vitro	FW
cord-001835-0s7ok4uw	4550	4	assays	assay	NNS
cord-001835-0s7ok4uw	4550	5	,	,	,
cord-001835-0s7ok4uw	4550	6	Tau	Tau	NNP
cord-001835-0s7ok4uw	4550	7	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4550	8	by	by	IN
cord-001835-0s7ok4uw	4550	9	rat	rat	NN
cord-001835-0s7ok4uw	4550	10	brain	brain	NN
cord-001835-0s7ok4uw	4550	11	extract	extract	NN
cord-001835-0s7ok4uw	4550	12	is	be	VBZ
cord-001835-0s7ok4uw	4550	13	considered	consider	VBN
cord-001835-0s7ok4uw	4550	14	as	as	IN
cord-001835-0s7ok4uw	4550	15	an	an	DT
cord-001835-0s7ok4uw	4550	16	hyperphosphorylation	hyperphosphorylation	NN
cord-001835-0s7ok4uw	4550	17	model	model	NN
cord-001835-0s7ok4uw	4550	18	that	that	WDT
cord-001835-0s7ok4uw	4550	19	was	be	VBD
cord-001835-0s7ok4uw	4550	20	furthermore	furthermore	RB
cord-001835-0s7ok4uw	4550	21	pointed	point	VBN
cord-001835-0s7ok4uw	4550	22	out	out	RP
cord-001835-0s7ok4uw	4550	23	to	to	TO
cord-001835-0s7ok4uw	4550	24	enable	enable	VB
cord-001835-0s7ok4uw	4550	25	Tau	Tau	NNP
cord-001835-0s7ok4uw	4550	26	aggregation	aggregation	NN
cord-001835-0s7ok4uw	4550	27	[	[	-LRB-
cord-001835-0s7ok4uw	4550	28	1	1	CD
cord-001835-0s7ok4uw	4550	29	]	]	-RRB-
cord-001835-0s7ok4uw	4550	30	.	.	.
cord-001835-0s7ok4uw	4551	1	In	in	IN
cord-001835-0s7ok4uw	4551	2	a	a	DT
cord-001835-0s7ok4uw	4551	3	first	first	JJ
cord-001835-0s7ok4uw	4551	4	step	step	NN
cord-001835-0s7ok4uw	4551	5	,	,	,
cord-001835-0s7ok4uw	4551	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	4551	7	have	have	VBP
cord-001835-0s7ok4uw	4551	8	identified	identify	VBN
cord-001835-0s7ok4uw	4551	9	all	all	PDT
cord-001835-0s7ok4uw	4551	10	the	the	DT
cord-001835-0s7ok4uw	4551	11	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4551	12	sites	site	NNS
cord-001835-0s7ok4uw	4551	13	of	of	IN
cord-001835-0s7ok4uw	4551	14	rat	rat	NN
cord-001835-0s7ok4uw	4551	15	brain	brain	NN
cord-001835-0s7ok4uw	4551	16	extract	extract	NN
cord-001835-0s7ok4uw	4552	1	phosphorylated	phosphorylate	VBN
cord-001835-0s7ok4uw	4552	2	-	-	HYPH
cord-001835-0s7ok4uw	4552	3	Tau	Tau	NNP
cord-001835-0s7ok4uw	4552	4	,	,	,
cord-001835-0s7ok4uw	4552	5	using	use	VBG
cord-001835-0s7ok4uw	4552	6	the	the	DT
cord-001835-0s7ok4uw	4552	7	analytical	analytical	JJ
cord-001835-0s7ok4uw	4552	8	capacity	capacity	NN
cord-001835-0s7ok4uw	4552	9	of	of	IN
cord-001835-0s7ok4uw	4552	10	NMR	NMR	NNP
cord-001835-0s7ok4uw	4552	11	.	.	.
cord-001835-0s7ok4uw	4553	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4553	2	showed	show	VBD
cord-001835-0s7ok4uw	4553	3	that	that	IN
cord-001835-0s7ok4uw	4553	4	the	the	DT
cord-001835-0s7ok4uw	4553	5	protein	protein	NN
cord-001835-0s7ok4uw	4553	6	is	be	VBZ
cord-001835-0s7ok4uw	4553	7	modified	modify	VBN
cord-001835-0s7ok4uw	4553	8	at	at	IN
cord-001835-0s7ok4uw	4553	9	20	20	CD
cord-001835-0s7ok4uw	4553	10	Ser	Ser	NNP
cord-001835-0s7ok4uw	4553	11	/	/	SYM
cord-001835-0s7ok4uw	4553	12	Thr	Thr	NNP
cord-001835-0s7ok4uw	4553	13	sites	site	NNS
cord-001835-0s7ok4uw	4553	14	.	.	.
cord-001835-0s7ok4uw	4554	1	Among	among	IN
cord-001835-0s7ok4uw	4554	2	the	the	DT
cord-001835-0s7ok4uw	4554	3	kinases	kinase	NNS
cord-001835-0s7ok4uw	4554	4	that	that	WDT
cord-001835-0s7ok4uw	4554	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4554	6	have	have	VBP
cord-001835-0s7ok4uw	4554	7	characterized	characterize	VBN
cord-001835-0s7ok4uw	4554	8	so	so	RB
cord-001835-0s7ok4uw	4554	9	far	far	RB
cord-001835-0s7ok4uw	4554	10	using	use	VBG
cord-001835-0s7ok4uw	4554	11	Tau	Tau	NNP
cord-001835-0s7ok4uw	4554	12	as	as	IN
cord-001835-0s7ok4uw	4554	13	substrate	substrate	NN
cord-001835-0s7ok4uw	4554	14	,	,	,
cord-001835-0s7ok4uw	4554	15	only	only	RB
cord-001835-0s7ok4uw	4554	16	the	the	DT
cord-001835-0s7ok4uw	4554	17	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	4554	18	signal	signal	NN
cord-001835-0s7ok4uw	4554	19	-	-	HYPH
cord-001835-0s7ok4uw	4554	20	regulated	regulate	VBN
cord-001835-0s7ok4uw	4554	21	kinase2	kinase2	NN
cord-001835-0s7ok4uw	4554	22	(	(	-LRB-
cord-001835-0s7ok4uw	4554	23	ERK2	ERK2	NNP
cord-001835-0s7ok4uw	4554	24	)	)	-RRB-
cord-001835-0s7ok4uw	4554	25	shows	show	VBZ
cord-001835-0s7ok4uw	4554	26	an	an	DT
cord-001835-0s7ok4uw	4554	27	ability	ability	NN
cord-001835-0s7ok4uw	4554	28	to	to	TO
cord-001835-0s7ok4uw	4554	29	modify	modify	VB
cord-001835-0s7ok4uw	4554	30	in	in	IN
cord-001835-0s7ok4uw	4554	31	vitro	vitro	FW
cord-001835-0s7ok4uw	4554	32	Tau	Tau	NNP
cord-001835-0s7ok4uw	4554	33	protein	protein	NN
cord-001835-0s7ok4uw	4554	34	on	on	IN
cord-001835-0s7ok4uw	4554	35	so	so	RB
cord-001835-0s7ok4uw	4554	36	many	many	JJ
cord-001835-0s7ok4uw	4554	37	sites	site	NNS
cord-001835-0s7ok4uw	4554	38	.	.	.
cord-001835-0s7ok4uw	4555	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4555	2	have	have	VBP
cord-001835-0s7ok4uw	4555	3	indeed	indeed	RB
cord-001835-0s7ok4uw	4555	4	identified	identify	VBN
cord-001835-0s7ok4uw	4555	5	14	14	CD
cord-001835-0s7ok4uw	4555	6	phosphorylated	phosphorylate	VBN
cord-001835-0s7ok4uw	4555	7	Ser	Ser	NNP
cord-001835-0s7ok4uw	4555	8	/	/	SYM
cord-001835-0s7ok4uw	4555	9	Thr	Thr	NNP
cord-001835-0s7ok4uw	4555	10	-	-	HYPH
cord-001835-0s7ok4uw	4555	11	Pro	pro	JJ
cord-001835-0s7ok4uw	4555	12	motifs	motif	NNS
cord-001835-0s7ok4uw	4555	13	out	out	IN
cord-001835-0s7ok4uw	4555	14	of	of	IN
cord-001835-0s7ok4uw	4555	15	18	18	CD
cord-001835-0s7ok4uw	4555	16	potential	potential	JJ
cord-001835-0s7ok4uw	4555	17	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4555	18	sites	site	NNS
cord-001835-0s7ok4uw	4555	19	in	in	IN
cord-001835-0s7ok4uw	4555	20	the	the	DT
cord-001835-0s7ok4uw	4555	21	sequence	sequence	NN
cord-001835-0s7ok4uw	4555	22	of	of	IN
cord-001835-0s7ok4uw	4555	23	full	full	JJ
cord-001835-0s7ok4uw	4555	24	length	length	NN
cord-001835-0s7ok4uw	4555	25	441-residue	441-residue	CD
cord-001835-0s7ok4uw	4555	26	Tau	tau	NN
cord-001835-0s7ok4uw	4555	27	.	.	.
cord-001835-0s7ok4uw	4556	1	In	in	IN
cord-001835-0s7ok4uw	4556	2	addition	addition	NN
cord-001835-0s7ok4uw	4556	3	,	,	,
cord-001835-0s7ok4uw	4556	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	4556	5	showed	show	VBD
cord-001835-0s7ok4uw	4556	6	using	use	VBG
cord-001835-0s7ok4uw	4556	7	Transmission	transmission	NN
cord-001835-0s7ok4uw	4556	8	Electron	electron	NN
cord-001835-0s7ok4uw	4556	9	Microscope	microscope	NN
cord-001835-0s7ok4uw	4556	10	(	(	-LRB-
cord-001835-0s7ok4uw	4556	11	TEM	tem	NN
cord-001835-0s7ok4uw	4556	12	)	)	-RRB-
cord-001835-0s7ok4uw	4556	13	a	a	DT
cord-001835-0s7ok4uw	4556	14	similar	similar	JJ
cord-001835-0s7ok4uw	4556	15	in	in	IN
cord-001835-0s7ok4uw	4556	16	vitro	vitro	FW
cord-001835-0s7ok4uw	4556	17	aggregation	aggregation	NN
cord-001835-0s7ok4uw	4556	18	capacity	capacity	NN
cord-001835-0s7ok4uw	4556	19	of	of	IN
cord-001835-0s7ok4uw	4556	20	ERK	ERK	NNP
cord-001835-0s7ok4uw	4556	21	-	-	HYPH
cord-001835-0s7ok4uw	4556	22	phosphorylated	phosphorylate	VBN
cord-001835-0s7ok4uw	4556	23	Tau	Tau	NNP
cord-001835-0s7ok4uw	4556	24	protein	protein	NN
cord-001835-0s7ok4uw	4556	25	compared	compare	VBN
cord-001835-0s7ok4uw	4556	26	to	to	IN
cord-001835-0s7ok4uw	4556	27	that	that	DT
cord-001835-0s7ok4uw	4556	28	of	of	IN
cord-001835-0s7ok4uw	4556	29	rat	rat	NN
cord-001835-0s7ok4uw	4556	30	brain	brain	NN
cord-001835-0s7ok4uw	4556	31	extract	extract	NN
cord-001835-0s7ok4uw	4556	32	phosphorylated	phosphorylate	VBN
cord-001835-0s7ok4uw	4556	33	-	-	HYPH
cord-001835-0s7ok4uw	4556	34	Tau	tau	NN
cord-001835-0s7ok4uw	4556	35	.	.	.
cord-001835-0s7ok4uw	4557	1	This	this	DT
cord-001835-0s7ok4uw	4557	2	shows	show	VBZ
cord-001835-0s7ok4uw	4557	3	that	that	IN
cord-001835-0s7ok4uw	4557	4	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4557	5	by	by	IN
cord-001835-0s7ok4uw	4557	6	the	the	DT
cord-001835-0s7ok4uw	4557	7	ERK	ERK	NNP
cord-001835-0s7ok4uw	4557	8	kinase	kinase	NN
cord-001835-0s7ok4uw	4557	9	generates	generate	VBZ
cord-001835-0s7ok4uw	4557	10	an	an	DT
cord-001835-0s7ok4uw	4557	11	hyperphosphorylated	hyperphosphorylate	VBN
cord-001835-0s7ok4uw	4557	12	Tau	Tau	NNP
cord-001835-0s7ok4uw	4557	13	.	.	.
cord-001835-0s7ok4uw	4558	1	Given	give	VBN
cord-001835-0s7ok4uw	4558	2	the	the	DT
cord-001835-0s7ok4uw	4558	3	high	high	JJ
cord-001835-0s7ok4uw	4558	4	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4558	5	of	of	IN
cord-001835-0s7ok4uw	4558	6	ERK	ERK	NNP
cord-001835-0s7ok4uw	4558	7	towards	towards	IN
cord-001835-0s7ok4uw	4558	8	Tau	Tau	NNP
cord-001835-0s7ok4uw	4558	9	,	,	,
cord-001835-0s7ok4uw	4558	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	4558	11	have	have	VBP
cord-001835-0s7ok4uw	4558	12	next	next	RB
cord-001835-0s7ok4uw	4558	13	looked	look	VBN
cord-001835-0s7ok4uw	4558	14	into	into	IN
cord-001835-0s7ok4uw	4558	15	the	the	DT
cord-001835-0s7ok4uw	4558	16	mechanism	mechanism	NN
cord-001835-0s7ok4uw	4558	17	of	of	IN
cord-001835-0s7ok4uw	4558	18	Tau	Tau	NNP
cord-001835-0s7ok4uw	4558	19	recognition	recognition	NN
cord-001835-0s7ok4uw	4558	20	.	.	.
cord-001835-0s7ok4uw	4559	1	ERK	ERK	NNP
cord-001835-0s7ok4uw	4559	2	kinase	kinase	NN
cord-001835-0s7ok4uw	4559	3	possesses	possess	VBZ
cord-001835-0s7ok4uw	4559	4	two	two	CD
cord-001835-0s7ok4uw	4559	5	well	well	RB
cord-001835-0s7ok4uw	4559	6	-	-	HYPH
cord-001835-0s7ok4uw	4559	7	characterized	characterize	VBN
cord-001835-0s7ok4uw	4559	8	docking	docking	NN
cord-001835-0s7ok4uw	4559	9	domains	domain	NNS
cord-001835-0s7ok4uw	4559	10	:	:	:
cord-001835-0s7ok4uw	4559	11	D	D	NNP
cord-001835-0s7ok4uw	4559	12	Recruitment	Recruitment	NNP
cord-001835-0s7ok4uw	4559	13	Sites	Sites	NNPS
cord-001835-0s7ok4uw	4559	14	(	(	-LRB-
cord-001835-0s7ok4uw	4559	15	DRS	DRS	NNP
cord-001835-0s7ok4uw	4559	16	)	)	-RRB-
cord-001835-0s7ok4uw	4559	17	and	and	CC
cord-001835-0s7ok4uw	4559	18	F	F	NNP
cord-001835-0s7ok4uw	4559	19	Recruitment	Recruitment	NNP
cord-001835-0s7ok4uw	4559	20	Sites	Sites	NNPS
cord-001835-0s7ok4uw	4559	21	(	(	-LRB-
cord-001835-0s7ok4uw	4559	22	FRS	FRS	NNP
cord-001835-0s7ok4uw	4559	23	)	)	-RRB-
cord-001835-0s7ok4uw	4559	24	,	,	,
cord-001835-0s7ok4uw	4559	25	which	which	WDT
cord-001835-0s7ok4uw	4559	26	recruit	recruit	VBP
cord-001835-0s7ok4uw	4559	27	complementary	complementary	JJ
cord-001835-0s7ok4uw	4559	28	docking	docking	NN
cord-001835-0s7ok4uw	4559	29	sites	site	NNS
cord-001835-0s7ok4uw	4559	30	and	and	CC
cord-001835-0s7ok4uw	4559	31	increase	increase	VB
cord-001835-0s7ok4uw	4559	32	the	the	DT
cord-001835-0s7ok4uw	4559	33	specificity	specificity	NN
cord-001835-0s7ok4uw	4559	34	and	and	CC
cord-001835-0s7ok4uw	4559	35	efficiency	efficiency	NN
cord-001835-0s7ok4uw	4559	36	of	of	IN
cord-001835-0s7ok4uw	4559	37	the	the	DT
cord-001835-0s7ok4uw	4559	38	interaction	interaction	NN
cord-001835-0s7ok4uw	4559	39	with	with	IN
cord-001835-0s7ok4uw	4559	40	both	both	CC
cord-001835-0s7ok4uw	4559	41	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4559	42	upstream	upstream	JJ
cord-001835-0s7ok4uw	4559	43	regulators	regulator	NNS
cord-001835-0s7ok4uw	4559	44	and	and	CC
cord-001835-0s7ok4uw	4559	45	downstream	downstream	JJ
cord-001835-0s7ok4uw	4559	46	substrates	substrate	NNS
cord-001835-0s7ok4uw	4559	47	[	[	-LRB-
cord-001835-0s7ok4uw	4559	48	3	3	CD
cord-001835-0s7ok4uw	4559	49	]	]	-RRB-
cord-001835-0s7ok4uw	4559	50	.	.	.
cord-001835-0s7ok4uw	4560	1	As	as	IN
cord-001835-0s7ok4uw	4560	2	the	the	DT
cord-001835-0s7ok4uw	4560	3	interaction	interaction	NN
cord-001835-0s7ok4uw	4560	4	between	between	IN
cord-001835-0s7ok4uw	4560	5	Tau	Tau	NNP
cord-001835-0s7ok4uw	4560	6	protein	protein	NN
cord-001835-0s7ok4uw	4560	7	and	and	CC
cord-001835-0s7ok4uw	4560	8	ERK2	ERK2	NNP
cord-001835-0s7ok4uw	4560	9	kinase	kinase	NN
cord-001835-0s7ok4uw	4560	10	is	be	VBZ
cord-001835-0s7ok4uw	4560	11	analyzed	analyze	VBN
cord-001835-0s7ok4uw	4560	12	by	by	IN
cord-001835-0s7ok4uw	4560	13	NMR	NMR	NNP
cord-001835-0s7ok4uw	4560	14	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	4560	15	,	,	,
cord-001835-0s7ok4uw	4560	16	multiple	multiple	JJ
cord-001835-0s7ok4uw	4560	17	sites	site	NNS
cord-001835-0s7ok4uw	4560	18	of	of	IN
cord-001835-0s7ok4uw	4560	19	interaction	interaction	NN
cord-001835-0s7ok4uw	4560	20	are	be	VBP
cord-001835-0s7ok4uw	4560	21	observed	observe	VBN
cord-001835-0s7ok4uw	4560	22	along	along	IN
cord-001835-0s7ok4uw	4560	23	the	the	DT
cord-001835-0s7ok4uw	4560	24	Tau	Tau	NNP
cord-001835-0s7ok4uw	4560	25	sequence	sequence	NN
cord-001835-0s7ok4uw	4560	26	,	,	,
cord-001835-0s7ok4uw	4560	27	similar	similar	JJ
cord-001835-0s7ok4uw	4560	28	to	to	IN
cord-001835-0s7ok4uw	4560	29	DRS	drs	JJ
cord-001835-0s7ok4uw	4560	30	docking	docking	NN
cord-001835-0s7ok4uw	4560	31	sites	site	NNS
cord-001835-0s7ok4uw	4560	32	,	,	,
cord-001835-0s7ok4uw	4560	33	all	all	DT
cord-001835-0s7ok4uw	4560	34	located	locate	VBN
cord-001835-0s7ok4uw	4560	35	in	in	IN
cord-001835-0s7ok4uw	4560	36	the	the	DT
cord-001835-0s7ok4uw	4560	37	so	so	RB
cord-001835-0s7ok4uw	4560	38	-	-	HYPH
cord-001835-0s7ok4uw	4560	39	called	call	VBN
cord-001835-0s7ok4uw	4560	40	microtubule	microtubule	NN
cord-001835-0s7ok4uw	4560	41	binding	bind	VBG
cord-001835-0s7ok4uw	4560	42	domain	domain	NN
cord-001835-0s7ok4uw	4560	43	of	of	IN
cord-001835-0s7ok4uw	4560	44	Tau	Tau	NNP
cord-001835-0s7ok4uw	4560	45	.	.	.
cord-001835-0s7ok4uw	4561	1	These	these	DT
cord-001835-0s7ok4uw	4561	2	sites	site	NNS
cord-001835-0s7ok4uw	4561	3	are	be	VBP
cord-001835-0s7ok4uw	4561	4	short	short	JJ
cord-001835-0s7ok4uw	4561	5	sequences	sequence	NNS
cord-001835-0s7ok4uw	4561	6	loosely	loosely	RB
cord-001835-0s7ok4uw	4561	7	matching	match	VBG
cord-001835-0s7ok4uw	4561	8	the	the	DT
cord-001835-0s7ok4uw	4561	9	reported	report	VBN
cord-001835-0s7ok4uw	4561	10	consensus	consensus	NN
cord-001835-0s7ok4uw	4561	11	for	for	IN
cord-001835-0s7ok4uw	4561	12	D	D	NNP
cord-001835-0s7ok4uw	4561	13	sites	site	NNS
cord-001835-0s7ok4uw	4561	14	w1	w1	NNP
cord-001835-0s7ok4uw	4561	15	-	-	HYPH
cord-001835-0s7ok4uw	4561	16	3uxu	3uxu	NNP
cord-001835-0s7ok4uw	4561	17	(	(	-LRB-
cord-001835-0s7ok4uw	4561	18	w	w	NNP
cord-001835-0s7ok4uw	4561	19	,	,	,
cord-001835-0s7ok4uw	4561	20	u	u	NNP
cord-001835-0s7ok4uw	4561	21	,	,	,
cord-001835-0s7ok4uw	4561	22	and	and	CC
cord-001835-0s7ok4uw	4561	23	x	x	LS
cord-001835-0s7ok4uw	4561	24	refer	refer	NN
cord-001835-0s7ok4uw	4561	25	to	to	IN
cord-001835-0s7ok4uw	4561	26	positively	positively	RB
cord-001835-0s7ok4uw	4561	27	charged	charge	VBN
cord-001835-0s7ok4uw	4561	28	,	,	,
cord-001835-0s7ok4uw	4561	29	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	4561	30	,	,	,
cord-001835-0s7ok4uw	4561	31	or	or	CC
cord-001835-0s7ok4uw	4561	32	any	any	DT
cord-001835-0s7ok4uw	4561	33	intervening	intervene	VBG
cord-001835-0s7ok4uw	4561	34	residues	residue	NNS
cord-001835-0s7ok4uw	4561	35	,	,	,
cord-001835-0s7ok4uw	4561	36	respectively	respectively	RB
cord-001835-0s7ok4uw	4561	37	)	)	-RRB-
cord-001835-0s7ok4uw	4561	38	[	[	-LRB-
cord-001835-0s7ok4uw	4561	39	3	3	CD
cord-001835-0s7ok4uw	4561	40	]	]	-RRB-
cord-001835-0s7ok4uw	4561	41	,	,	.
cord-001835-0s7ok4uw	4562	1	and	and	CC
cord-001835-0s7ok4uw	4562	2	also	also	RB
cord-001835-0s7ok4uw	4562	3	the	the	DT
cord-001835-0s7ok4uw	4562	4	reverse	reverse	JJ
cord-001835-0s7ok4uw	4562	5	sequence	sequence	NN
cord-001835-0s7ok4uw	4562	6	uxuw	uxuw	NN
cord-001835-0s7ok4uw	4563	1	1	1	LS
cord-001835-0s7ok4uw	4563	2	-	-	SYM
cord-001835-0s7ok4uw	4563	3	3.To	3.To	NNP
cord-001835-0s7ok4uw	4563	4	confirm	confirm	VBP
cord-001835-0s7ok4uw	4563	5	the	the	DT
cord-001835-0s7ok4uw	4563	6	mapping	mapping	NN
cord-001835-0s7ok4uw	4563	7	of	of	IN
cord-001835-0s7ok4uw	4563	8	the	the	DT
cord-001835-0s7ok4uw	4563	9	interaction	interaction	NN
cord-001835-0s7ok4uw	4563	10	,	,	,
cord-001835-0s7ok4uw	4563	11	two	two	CD
cord-001835-0s7ok4uw	4563	12	Tau	Tau	NNP
cord-001835-0s7ok4uw	4563	13	recognition	recognition	NN
cord-001835-0s7ok4uw	4563	14	sites	site	NNS
cord-001835-0s7ok4uw	4563	15	were	be	VBD
cord-001835-0s7ok4uw	4563	16	produced	produce	VBN
cord-001835-0s7ok4uw	4563	17	as	as	IN
cord-001835-0s7ok4uw	4563	18	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	4563	19	peptides	peptide	NNS
cord-001835-0s7ok4uw	4563	20	of	of	IN
cord-001835-0s7ok4uw	4563	21	about	about	RB
cord-001835-0s7ok4uw	4563	22	20	20	CD
cord-001835-0s7ok4uw	4563	23	amino	amino	NN
cord-001835-0s7ok4uw	4563	24	-	-	HYPH
cord-001835-0s7ok4uw	4563	25	acid	acid	NN
cord-001835-0s7ok4uw	4563	26	in	in	IN
cord-001835-0s7ok4uw	4563	27	fusion	fusion	NN
cord-001835-0s7ok4uw	4563	28	with	with	IN
cord-001835-0s7ok4uw	4563	29	an	an	DT
cord-001835-0s7ok4uw	4563	30	N	n	CD
cord-001835-0s7ok4uw	4563	31	-	-	HYPH
cord-001835-0s7ok4uw	4563	32	terminal	terminal	NN
cord-001835-0s7ok4uw	4563	33	His	-PRON-	PRP$
cord-001835-0s7ok4uw	4563	34	-	-	HYPH
cord-001835-0s7ok4uw	4563	35	tag	tag	NN
cord-001835-0s7ok4uw	4563	36	Sumo	Sumo	NNP
cord-001835-0s7ok4uw	4563	37	.	.	.
cord-001835-0s7ok4uw	4564	1	Interaction	interaction	NN
cord-001835-0s7ok4uw	4564	2	assays	assay	NNS
cord-001835-0s7ok4uw	4564	3	using	use	VBG
cord-001835-0s7ok4uw	4564	4	2D	2D	VBN
cord-001835-0s7ok4uw	4564	5	[	[	-LRB-
cord-001835-0s7ok4uw	4564	6	1H	1h	CD
cord-001835-0s7ok4uw	4564	7	,	,	,
cord-001835-0s7ok4uw	4565	1	15N	15n	CD
cord-001835-0s7ok4uw	4565	2	]	]	-RRB-
cord-001835-0s7ok4uw	4565	3	HSQC	HSQC	NNP
cord-001835-0s7ok4uw	4565	4	spectra	spectrum	NNS
cord-001835-0s7ok4uw	4565	5	of	of	IN
cord-001835-0s7ok4uw	4565	6	the	the	DT
cord-001835-0s7ok4uw	4565	7	peptides	peptide	NNS
cord-001835-0s7ok4uw	4565	8	confirm	confirm	VBP
cord-001835-0s7ok4uw	4565	9	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4565	10	binding	binding	NN
cord-001835-0s7ok4uw	4565	11	to	to	IN
cord-001835-0s7ok4uw	4565	12	ERK	ERK	NNP
cord-001835-0s7ok4uw	4565	13	kinase	kinase	NN
cord-001835-0s7ok4uw	4565	14	.	.	.
cord-001835-0s7ok4uw	4566	1	The	the	DT
cord-001835-0s7ok4uw	4566	2	potential	potential	NN
cord-001835-0s7ok4uw	4566	3	of	of	IN
cord-001835-0s7ok4uw	4566	4	these	these	DT
cord-001835-0s7ok4uw	4566	5	peptides	peptide	NNS
cord-001835-0s7ok4uw	4566	6	to	to	TO
cord-001835-0s7ok4uw	4566	7	inhibit	inhibit	VB
cord-001835-0s7ok4uw	4566	8	ERK	ERK	NNP
cord-001835-0s7ok4uw	4566	9	activity	activity	NN
cord-001835-0s7ok4uw	4566	10	with	with	IN
cord-001835-0s7ok4uw	4566	11	Tau	Tau	NNP
cord-001835-0s7ok4uw	4566	12	as	as	IN
cord-001835-0s7ok4uw	4566	13	substrate	substrate	NN
cord-001835-0s7ok4uw	4566	14	is	be	VBZ
cord-001835-0s7ok4uw	4566	15	now	now	RB
cord-001835-0s7ok4uw	4566	16	being	be	VBG
cord-001835-0s7ok4uw	4566	17	investigated	investigate	VBN
cord-001835-0s7ok4uw	4566	18	.	.	.
cord-001835-0s7ok4uw	4567	1	While	while	IN
cord-001835-0s7ok4uw	4567	2	rigid	rigid	JJ
cord-001835-0s7ok4uw	4567	3	-	-	HYPH
cord-001835-0s7ok4uw	4567	4	body	body	NN
cord-001835-0s7ok4uw	4567	5	docking	docking	NN
cord-001835-0s7ok4uw	4567	6	has	have	VBZ
cord-001835-0s7ok4uw	4567	7	become	become	VBN
cord-001835-0s7ok4uw	4567	8	quite	quite	RB
cord-001835-0s7ok4uw	4567	9	successful	successful	JJ
cord-001835-0s7ok4uw	4567	10	for	for	IN
cord-001835-0s7ok4uw	4567	11	predicting	predict	VBG
cord-001835-0s7ok4uw	4567	12	the	the	DT
cord-001835-0s7ok4uw	4567	13	correct	correct	JJ
cord-001835-0s7ok4uw	4567	14	conformations	conformation	NNS
cord-001835-0s7ok4uw	4567	15	of	of	IN
cord-001835-0s7ok4uw	4567	16	binary	binary	JJ
cord-001835-0s7ok4uw	4567	17	protein	protein	NN
cord-001835-0s7ok4uw	4567	18	complexes	complex	NNS
cord-001835-0s7ok4uw	4567	19	,	,	,
cord-001835-0s7ok4uw	4567	20	determining	determine	VBG
cord-001835-0s7ok4uw	4567	21	whether	whether	IN
cord-001835-0s7ok4uw	4567	22	two	two	CD
cord-001835-0s7ok4uw	4567	23	given	give	VBN
cord-001835-0s7ok4uw	4567	24	proteins	protein	NNS
cord-001835-0s7ok4uw	4567	25	interact	interact	VBP
cord-001835-0s7ok4uw	4567	26	remains	remain	VBZ
cord-001835-0s7ok4uw	4567	27	a	a	DT
cord-001835-0s7ok4uw	4567	28	difficult	difficult	JJ
cord-001835-0s7ok4uw	4567	29	problem	problem	NN
cord-001835-0s7ok4uw	4567	30	.	.	.
cord-001835-0s7ok4uw	4568	1	Successful	successful	JJ
cord-001835-0s7ok4uw	4568	2	docking	docking	NN
cord-001835-0s7ok4uw	4568	3	procedures	procedure	NNS
cord-001835-0s7ok4uw	4568	4	often	often	RB
cord-001835-0s7ok4uw	4568	5	give	give	VBP
cord-001835-0s7ok4uw	4568	6	equally	equally	RB
cord-001835-0s7ok4uw	4568	7	good	good	JJ
cord-001835-0s7ok4uw	4568	8	scores	score	NNS
cord-001835-0s7ok4uw	4568	9	for	for	IN
cord-001835-0s7ok4uw	4568	10	pairs	pair	NNS
cord-001835-0s7ok4uw	4568	11	of	of	IN
cord-001835-0s7ok4uw	4568	12	proteins	protein	NNS
cord-001835-0s7ok4uw	4568	13	for	for	IN
cord-001835-0s7ok4uw	4568	14	which	which	WDT
cord-001835-0s7ok4uw	4568	15	there	there	EX
cord-001835-0s7ok4uw	4568	16	is	be	VBZ
cord-001835-0s7ok4uw	4568	17	no	no	DT
cord-001835-0s7ok4uw	4568	18	evidence	evidence	NN
cord-001835-0s7ok4uw	4568	19	of	of	IN
cord-001835-0s7ok4uw	4568	20	interaction	interaction	NN
cord-001835-0s7ok4uw	4568	21	.	.	.
cord-001835-0s7ok4uw	4569	1	Studies	study	NNS
cord-001835-0s7ok4uw	4569	2	investigating	investigate	VBG
cord-001835-0s7ok4uw	4569	3	what	what	WP
cord-001835-0s7ok4uw	4569	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	4569	5	define	define	VBP
cord-001835-0s7ok4uw	4569	6	as	as	IN
cord-001835-0s7ok4uw	4569	7	the	the	DT
cord-001835-0s7ok4uw	4569	8	'	'	``
cord-001835-0s7ok4uw	4569	9	pre	pre	JJ
cord-001835-0s7ok4uw	4569	10	-	-	JJ
cord-001835-0s7ok4uw	4569	11	docking	docking	JJ
cord-001835-0s7ok4uw	4569	12	'	'	''
cord-001835-0s7ok4uw	4569	13	problem	problem	NN
cord-001835-0s7ok4uw	4569	14	via	via	IN
cord-001835-0s7ok4uw	4569	15	in	in	IN
cord-001835-0s7ok4uw	4569	16	silico	silico	NN
cord-001835-0s7ok4uw	4569	17	approaches	approach	NNS
cord-001835-0s7ok4uw	4569	18	have	have	VBP
cord-001835-0s7ok4uw	4569	19	only	only	RB
cord-001835-0s7ok4uw	4569	20	recently	recently	RB
cord-001835-0s7ok4uw	4569	21	become	become	VBN
cord-001835-0s7ok4uw	4569	22	feasible	feasible	JJ
cord-001835-0s7ok4uw	4569	23	with	with	IN
cord-001835-0s7ok4uw	4569	24	the	the	DT
cord-001835-0s7ok4uw	4569	25	help	help	NN
cord-001835-0s7ok4uw	4569	26	of	of	IN
cord-001835-0s7ok4uw	4569	27	supercomputers	supercomputer	NNS
cord-001835-0s7ok4uw	4569	28	and	and	CC
cord-001835-0s7ok4uw	4569	29	gridcomputing	gridcompute	VBG
cord-001835-0s7ok4uw	4569	30	systems	system	NNS
cord-001835-0s7ok4uw	4569	31	.	.	.
cord-001835-0s7ok4uw	4570	1	In	in	IN
cord-001835-0s7ok4uw	4570	2	a	a	DT
cord-001835-0s7ok4uw	4570	3	previous	previous	JJ
cord-001835-0s7ok4uw	4570	4	work	work	NN
cord-001835-0s7ok4uw	4570	5	,	,	,
cord-001835-0s7ok4uw	4570	6	on	on	IN
cord-001835-0s7ok4uw	4570	7	a	a	DT
cord-001835-0s7ok4uw	4570	8	restricted	restricted	JJ
cord-001835-0s7ok4uw	4570	9	set	set	NN
cord-001835-0s7ok4uw	4570	10	of	of	IN
cord-001835-0s7ok4uw	4570	11	protein	protein	NN
cord-001835-0s7ok4uw	4570	12	complexes	complex	NNS
cord-001835-0s7ok4uw	4570	13	,	,	,
cord-001835-0s7ok4uw	4570	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	4570	15	showed	show	VBD
cord-001835-0s7ok4uw	4570	16	how	how	WRB
cord-001835-0s7ok4uw	4570	17	predictions	prediction	NNS
cord-001835-0s7ok4uw	4570	18	of	of	IN
cord-001835-0s7ok4uw	4570	19	interacting	interact	VBG
cord-001835-0s7ok4uw	4570	20	partners	partner	NNS
cord-001835-0s7ok4uw	4570	21	could	could	MD
cord-001835-0s7ok4uw	4570	22	be	be	VB
cord-001835-0s7ok4uw	4570	23	greatly	greatly	RB
cord-001835-0s7ok4uw	4570	24	improved	improve	VBN
cord-001835-0s7ok4uw	4570	25	if	if	IN
cord-001835-0s7ok4uw	4570	26	the	the	DT
cord-001835-0s7ok4uw	4570	27	location	location	NN
cord-001835-0s7ok4uw	4570	28	of	of	IN
cord-001835-0s7ok4uw	4570	29	the	the	DT
cord-001835-0s7ok4uw	4570	30	correct	correct	JJ
cord-001835-0s7ok4uw	4570	31	binding	binding	NN
cord-001835-0s7ok4uw	4570	32	interface	interface	NN
cord-001835-0s7ok4uw	4570	33	on	on	IN
cord-001835-0s7ok4uw	4570	34	each	each	DT
cord-001835-0s7ok4uw	4570	35	protein	protein	NN
cord-001835-0s7ok4uw	4570	36	was	be	VBD
cord-001835-0s7ok4uw	4570	37	known	know	VBN
cord-001835-0s7ok4uw	4570	38	.	.	.
cord-001835-0s7ok4uw	4571	1	Experimentally	experimentally	RB
cord-001835-0s7ok4uw	4571	2	identified	identify	VBN
cord-001835-0s7ok4uw	4571	3	complexes	complex	NNS
cord-001835-0s7ok4uw	4571	4	are	be	VBP
cord-001835-0s7ok4uw	4571	5	found	find	VBN
cord-001835-0s7ok4uw	4571	6	to	to	TO
cord-001835-0s7ok4uw	4571	7	be	be	VB
cord-001835-0s7ok4uw	4571	8	much	much	RB
cord-001835-0s7ok4uw	4571	9	more	more	RBR
cord-001835-0s7ok4uw	4571	10	likely	likely	JJ
cord-001835-0s7ok4uw	4571	11	to	to	TO
cord-001835-0s7ok4uw	4571	12	bring	bring	VB
cord-001835-0s7ok4uw	4571	13	these	these	DT
cord-001835-0s7ok4uw	4571	14	two	two	CD
cord-001835-0s7ok4uw	4571	15	interfaces	interface	NNS
cord-001835-0s7ok4uw	4571	16	into	into	IN
cord-001835-0s7ok4uw	4571	17	contact	contact	NN
cord-001835-0s7ok4uw	4571	18	,	,	,
cord-001835-0s7ok4uw	4571	19	at	at	IN
cord-001835-0s7ok4uw	4571	20	the	the	DT
cord-001835-0s7ok4uw	4571	21	same	same	JJ
cord-001835-0s7ok4uw	4571	22	time	time	NN
cord-001835-0s7ok4uw	4571	23	as	as	IN
cord-001835-0s7ok4uw	4571	24	yielding	yield	VBG
cord-001835-0s7ok4uw	4571	25	good	good	JJ
cord-001835-0s7ok4uw	4571	26	interaction	interaction	NN
cord-001835-0s7ok4uw	4571	27	energies	energy	NNS
cord-001835-0s7ok4uw	4571	28	.	.	.
cord-001835-0s7ok4uw	4572	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4572	2	present	present	VBP
cord-001835-0s7ok4uw	4572	3	data	datum	NNS
cord-001835-0s7ok4uw	4572	4	from	from	IN
cord-001835-0s7ok4uw	4572	5	a	a	DT
cord-001835-0s7ok4uw	4572	6	complete	complete	JJ
cord-001835-0s7ok4uw	4572	7	cross	cross	JJ
cord-001835-0s7ok4uw	4572	8	-	-	JJ
cord-001835-0s7ok4uw	4572	9	docking	docking	JJ
cord-001835-0s7ok4uw	4572	10	(	(	-LRB-
cord-001835-0s7ok4uw	4572	11	CC	cc	NN
cord-001835-0s7ok4uw	4572	12	-	-	HYPH
cord-001835-0s7ok4uw	4572	13	D	D	NNP
cord-001835-0s7ok4uw	4572	14	)	)	-RRB-
cord-001835-0s7ok4uw	4572	15	study	study	NN
cord-001835-0s7ok4uw	4572	16	of	of	IN
cord-001835-0s7ok4uw	4572	17	a	a	DT
cord-001835-0s7ok4uw	4572	18	database	database	NN
cord-001835-0s7ok4uw	4572	19	of	of	IN
cord-001835-0s7ok4uw	4572	20	168	168	CD
cord-001835-0s7ok4uw	4572	21	proteins	protein	NNS
cord-001835-0s7ok4uw	4572	22	,	,	,
cord-001835-0s7ok4uw	4572	23	including	include	VBG
cord-001835-0s7ok4uw	4572	24	the	the	DT
cord-001835-0s7ok4uw	4572	25	treatment	treatment	NN
cord-001835-0s7ok4uw	4572	26	of	of	IN
cord-001835-0s7ok4uw	4572	27	more	more	JJR
cord-001835-0s7ok4uw	4572	28	than	than	IN
cord-001835-0s7ok4uw	4572	29	14,000	14,000	CD
cord-001835-0s7ok4uw	4572	30	potential	potential	JJ
cord-001835-0s7ok4uw	4572	31	binary	binary	JJ
cord-001835-0s7ok4uw	4572	32	interactions	interaction	NNS
cord-001835-0s7ok4uw	4572	33	.	.	.
cord-001835-0s7ok4uw	4573	1	The	the	DT
cord-001835-0s7ok4uw	4573	2	performance	performance	NN
cord-001835-0s7ok4uw	4573	3	of	of	IN
cord-001835-0s7ok4uw	4573	4	the	the	DT
cord-001835-0s7ok4uw	4573	5	interaction	interaction	NN
cord-001835-0s7ok4uw	4573	6	index	index	NN
cord-001835-0s7ok4uw	4573	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	4573	8	developed	develop	VBD
cord-001835-0s7ok4uw	4573	9	to	to	TO
cord-001835-0s7ok4uw	4573	10	predict	predict	VB
cord-001835-0s7ok4uw	4573	11	binding	bind	VBG
cord-001835-0s7ok4uw	4573	12	probability	probability	NN
cord-001835-0s7ok4uw	4573	13	compares	compare	VBZ
cord-001835-0s7ok4uw	4573	14	well	well	RB
cord-001835-0s7ok4uw	4573	15	with	with	IN
cord-001835-0s7ok4uw	4573	16	other	other	JJ
cord-001835-0s7ok4uw	4573	17	methods	method	NNS
cord-001835-0s7ok4uw	4573	18	.	.	.
cord-001835-0s7ok4uw	4574	1	By	by	IN
cord-001835-0s7ok4uw	4574	2	studying	study	VBG
cord-001835-0s7ok4uw	4574	3	the	the	DT
cord-001835-0s7ok4uw	4574	4	interaction	interaction	NN
cord-001835-0s7ok4uw	4574	5	of	of	IN
cord-001835-0s7ok4uw	4574	6	all	all	DT
cord-001835-0s7ok4uw	4574	7	potential	potential	JJ
cord-001835-0s7ok4uw	4574	8	protein	protein	NN
cord-001835-0s7ok4uw	4574	9	pairs	pair	NNS
cord-001835-0s7ok4uw	4574	10	within	within	IN
cord-001835-0s7ok4uw	4574	11	a	a	DT
cord-001835-0s7ok4uw	4574	12	dataset	dataset	NN
cord-001835-0s7ok4uw	4574	13	,	,	,
cord-001835-0s7ok4uw	4574	14	CC	cc	NN
cord-001835-0s7ok4uw	4574	15	-	-	HYPH
cord-001835-0s7ok4uw	4574	16	D	d	JJ
cord-001835-0s7ok4uw	4574	17	calculations	calculation	NNS
cord-001835-0s7ok4uw	4574	18	can	can	MD
cord-001835-0s7ok4uw	4574	19	also	also	RB
cord-001835-0s7ok4uw	4574	20	help	help	VB
cord-001835-0s7ok4uw	4574	21	to	to	TO
cord-001835-0s7ok4uw	4574	22	identify	identify	VB
cord-001835-0s7ok4uw	4574	23	correct	correct	JJ
cord-001835-0s7ok4uw	4574	24	protein	protein	NN
cord-001835-0s7ok4uw	4574	25	interaction	interaction	NN
cord-001835-0s7ok4uw	4574	26	interfaces	interface	NNS
cord-001835-0s7ok4uw	4574	27	.	.	.
cord-001835-0s7ok4uw	4575	1	The	the	DT
cord-001835-0s7ok4uw	4575	2	present	present	JJ
cord-001835-0s7ok4uw	4575	3	large	large	JJ
cord-001835-0s7ok4uw	4575	4	-	-	HYPH
cord-001835-0s7ok4uw	4575	5	scale	scale	NN
cord-001835-0s7ok4uw	4575	6	study	study	NN
cord-001835-0s7ok4uw	4575	7	also	also	RB
cord-001835-0s7ok4uw	4575	8	reveals	reveal	VBZ
cord-001835-0s7ok4uw	4575	9	the	the	DT
cord-001835-0s7ok4uw	4575	10	influence	influence	NN
cord-001835-0s7ok4uw	4575	11	of	of	IN
cord-001835-0s7ok4uw	4575	12	various	various	JJ
cord-001835-0s7ok4uw	4575	13	protein	protein	NN
cord-001835-0s7ok4uw	4575	14	families	family	NNS
cord-001835-0s7ok4uw	4575	15	(	(	-LRB-
cord-001835-0s7ok4uw	4575	16	enzyme	enzyme	NN
cord-001835-0s7ok4uw	4575	17	-	-	HYPH
cord-001835-0s7ok4uw	4575	18	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	4575	19	,	,	,
cord-001835-0s7ok4uw	4575	20	antibody	antibody	NN
cord-001835-0s7ok4uw	4575	21	-	-	HYPH
cord-001835-0s7ok4uw	4575	22	antigen	antigen	NN
cord-001835-0s7ok4uw	4575	23	,	,	,
cord-001835-0s7ok4uw	4575	24	antigen	antigen	NN
cord-001835-0s7ok4uw	4575	25	-	-	HYPH
cord-001835-0s7ok4uw	4575	26	bound	bind	VBN
cord-001835-0s7ok4uw	4575	27	antibody	antibody	NN
cord-001835-0s7ok4uw	4575	28	,	,	,
cord-001835-0s7ok4uw	4575	29	etc	etc	FW
cord-001835-0s7ok4uw	4575	30	.	.	.
cord-001835-0s7ok4uw	4575	31	)	)	-RRB-
cord-001835-0s7ok4uw	4576	1	on	on	IN
cord-001835-0s7ok4uw	4576	2	binding	bind	VBG
cord-001835-0s7ok4uw	4576	3	specificity	specificity	NN
cord-001835-0s7ok4uw	4576	4	,	,	,
cord-001835-0s7ok4uw	4576	5	showing	show	VBG
cord-001835-0s7ok4uw	4576	6	,	,	,
cord-001835-0s7ok4uw	4576	7	in	in	IN
cord-001835-0s7ok4uw	4576	8	particular	particular	JJ
cord-001835-0s7ok4uw	4576	9	,	,	,
cord-001835-0s7ok4uw	4576	10	the	the	DT
cord-001835-0s7ok4uw	4576	11	distinctive	distinctive	JJ
cord-001835-0s7ok4uw	4576	12	behavior	behavior	NN
cord-001835-0s7ok4uw	4576	13	of	of	IN
cord-001835-0s7ok4uw	4576	14	antigenic	antigenic	JJ
cord-001835-0s7ok4uw	4576	15	interfaces	interface	NNS
cord-001835-0s7ok4uw	4576	16	compared	compare	VBN
cord-001835-0s7ok4uw	4576	17	to	to	IN
cord-001835-0s7ok4uw	4576	18	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4576	19	,	,	,
cord-001835-0s7ok4uw	4576	20	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4576	21	or	or	CC
cord-001835-0s7ok4uw	4576	22	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4576	23	.	.	.
cord-001835-0s7ok4uw	4577	1	The	the	DT
cord-001835-0s7ok4uw	4577	2	performance	performance	NN
cord-001835-0s7ok4uw	4577	3	of	of	IN
cord-001835-0s7ok4uw	4577	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4577	5	approach	approach	NN
cord-001835-0s7ok4uw	4577	6	is	be	VBZ
cord-001835-0s7ok4uw	4577	7	encouraging	encouraging	JJ
cord-001835-0s7ok4uw	4577	8	.	.	.
cord-001835-0s7ok4uw	4578	1	Although	although	IN
cord-001835-0s7ok4uw	4578	2	identifying	identify	VBG
cord-001835-0s7ok4uw	4578	3	interaction	interaction	NN
cord-001835-0s7ok4uw	4578	4	interfaces	interface	NNS
cord-001835-0s7ok4uw	4578	5	significantly	significantly	RB
cord-001835-0s7ok4uw	4578	6	helps	help	VBZ
cord-001835-0s7ok4uw	4578	7	in	in	IN
cord-001835-0s7ok4uw	4578	8	the	the	DT
cord-001835-0s7ok4uw	4578	9	identification	identification	NN
cord-001835-0s7ok4uw	4578	10	of	of	IN
cord-001835-0s7ok4uw	4578	11	interacting	interact	VBG
cord-001835-0s7ok4uw	4578	12	proteins	protein	NNS
cord-001835-0s7ok4uw	4578	13	,	,	,
cord-001835-0s7ok4uw	4578	14	further	further	JJ
cord-001835-0s7ok4uw	4578	15	refinements	refinement	NNS
cord-001835-0s7ok4uw	4578	16	will	will	MD
cord-001835-0s7ok4uw	4578	17	be	be	VB
cord-001835-0s7ok4uw	4578	18	necessary	necessary	JJ
cord-001835-0s7ok4uw	4578	19	to	to	TO
cord-001835-0s7ok4uw	4578	20	make	make	VB
cord-001835-0s7ok4uw	4578	21	in	in	IN
cord-001835-0s7ok4uw	4578	22	silico	silico	NN
cord-001835-0s7ok4uw	4578	23	cross	cross	JJ
cord-001835-0s7ok4uw	4578	24	-	-	JJ
cord-001835-0s7ok4uw	4578	25	docking	dock	VBG
cord-001835-0s7ok4uw	4578	26	a	a	DT
cord-001835-0s7ok4uw	4578	27	viable	viable	JJ
cord-001835-0s7ok4uw	4578	28	alternative	alternative	NN
cord-001835-0s7ok4uw	4578	29	to	to	IN
cord-001835-0s7ok4uw	4578	30	high	high	JJ
cord-001835-0s7ok4uw	4578	31	-	-	HYPH
cord-001835-0s7ok4uw	4578	32	throughput	throughput	NN
cord-001835-0s7ok4uw	4578	33	experimental	experimental	JJ
cord-001835-0s7ok4uw	4578	34	methods	method	NNS
cord-001835-0s7ok4uw	4578	35	.	.	.
cord-001835-0s7ok4uw	4579	1	Whole	whole	JJ
cord-001835-0s7ok4uw	4579	2	-	-	HYPH
cord-001835-0s7ok4uw	4579	3	protein	protein	NN
cord-001835-0s7ok4uw	4579	4	mass	mass	NN
cord-001835-0s7ok4uw	4579	5	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4579	6	reveals	reveal	VBZ
cord-001835-0s7ok4uw	4579	7	global	global	JJ
cord-001835-0s7ok4uw	4579	8	changes	change	NNS
cord-001835-0s7ok4uw	4579	9	to	to	IN
cord-001835-0s7ok4uw	4579	10	histone	histone	NN
cord-001835-0s7ok4uw	4579	11	modification	modification	NN
cord-001835-0s7ok4uw	4579	12	patterns	pattern	NNS
cord-001835-0s7ok4uw	4579	13	in	in	IN
cord-001835-0s7ok4uw	4579	14	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	4579	15	Sarah	Sarah	NNP
cord-001835-0s7ok4uw	4579	16	Wilkins	Wilkins	NNP
cord-001835-0s7ok4uw	4579	17	1	1	CD
cord-001835-0s7ok4uw	4579	18	,	,	,
cord-001835-0s7ok4uw	4579	19	Kuo	Kuo	NNP
cord-001835-0s7ok4uw	4579	20	-	-	HYPH
cord-001835-0s7ok4uw	4579	21	Feng	Feng	NNP
cord-001835-0s7ok4uw	4579	22	Hsu	Hsu	NNP
cord-001835-0s7ok4uw	4579	23	1	1	CD
cord-001835-0s7ok4uw	4579	24	,	,	,
cord-001835-0s7ok4uw	4579	25	Christopher	Christopher	NNP
cord-001835-0s7ok4uw	4579	26	Schofield	Schofield	NNP
cord-001835-0s7ok4uw	4579	27	1	1	CD
cord-001835-0s7ok4uw	4579	28	1	1	CD
cord-001835-0s7ok4uw	4579	29	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	4579	30	Research	Research	NNP
cord-001835-0s7ok4uw	4579	31	Laboratory	Laboratory	NNP
cord-001835-0s7ok4uw	4579	32	,	,	,
cord-001835-0s7ok4uw	4579	33	Oxford	Oxford	NNP
cord-001835-0s7ok4uw	4579	34	University	University	NNP
cord-001835-0s7ok4uw	4579	35	Cells	Cells	NNPS
cord-001835-0s7ok4uw	4579	36	respond	respond	VBP
cord-001835-0s7ok4uw	4579	37	to	to	IN
cord-001835-0s7ok4uw	4579	38	limiting	limit	VBG
cord-001835-0s7ok4uw	4579	39	oxygen	oxygen	NN
cord-001835-0s7ok4uw	4579	40	availability	availability	NN
cord-001835-0s7ok4uw	4579	41	(	(	-LRB-
cord-001835-0s7ok4uw	4579	42	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	4579	43	)	)	-RRB-
cord-001835-0s7ok4uw	4579	44	by	by	IN
cord-001835-0s7ok4uw	4579	45	altering	alter	VBG
cord-001835-0s7ok4uw	4579	46	the	the	DT
cord-001835-0s7ok4uw	4579	47	gene	gene	NN
cord-001835-0s7ok4uw	4579	48	expression	expression	NN
cord-001835-0s7ok4uw	4579	49	profile	profile	NN
cord-001835-0s7ok4uw	4579	50	.	.	.
cord-001835-0s7ok4uw	4580	1	This	this	DT
cord-001835-0s7ok4uw	4580	2	primarily	primarily	RB
cord-001835-0s7ok4uw	4580	3	involves	involve	VBZ
cord-001835-0s7ok4uw	4580	4	changes	change	NNS
cord-001835-0s7ok4uw	4580	5	at	at	IN
cord-001835-0s7ok4uw	4580	6	the	the	DT
cord-001835-0s7ok4uw	4580	7	level	level	NN
cord-001835-0s7ok4uw	4580	8	of	of	IN
cord-001835-0s7ok4uw	4580	9	transcription	transcription	NN
cord-001835-0s7ok4uw	4580	10	via	via	IN
cord-001835-0s7ok4uw	4580	11	the	the	DT
cord-001835-0s7ok4uw	4580	12	activity	activity	NN
cord-001835-0s7ok4uw	4580	13	of	of	IN
cord-001835-0s7ok4uw	4580	14	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	4580	15	-	-	HYPH
cord-001835-0s7ok4uw	4580	16	responsive	responsive	JJ
cord-001835-0s7ok4uw	4580	17	transcription	transcription	NN
cord-001835-0s7ok4uw	4580	18	factors	factor	NNS
cord-001835-0s7ok4uw	4580	19	,	,	,
cord-001835-0s7ok4uw	4580	20	although	although	IN
cord-001835-0s7ok4uw	4580	21	increasing	increase	VBG
cord-001835-0s7ok4uw	4580	22	evidence	evidence	NN
cord-001835-0s7ok4uw	4580	23	suggests	suggest	VBZ
cord-001835-0s7ok4uw	4580	24	that	that	IN
cord-001835-0s7ok4uw	4580	25	changes	change	NNS
cord-001835-0s7ok4uw	4580	26	in	in	IN
cord-001835-0s7ok4uw	4580	27	chromatin	chromatin	NN
cord-001835-0s7ok4uw	4580	28	structure	structure	NN
cord-001835-0s7ok4uw	4580	29	(	(	-LRB-
cord-001835-0s7ok4uw	4580	30	i.e.	i.e.	FW
cord-001835-0s7ok4uw	4580	31	from	from	IN
cord-001835-0s7ok4uw	4580	32	a	a	DT
cord-001835-0s7ok4uw	4580	33	condensed	condensed	JJ
cord-001835-0s7ok4uw	4580	34	'	'	``
cord-001835-0s7ok4uw	4580	35	silent	silent	JJ
cord-001835-0s7ok4uw	4580	36	'	'	''
cord-001835-0s7ok4uw	4580	37	state	state	NN
cord-001835-0s7ok4uw	4580	38	to	to	IN
cord-001835-0s7ok4uw	4580	39	a	a	DT
cord-001835-0s7ok4uw	4580	40	more	more	RBR
cord-001835-0s7ok4uw	4580	41	open	open	JJ
cord-001835-0s7ok4uw	4580	42	or	or	CC
cord-001835-0s7ok4uw	4580	43	'	'	``
cord-001835-0s7ok4uw	4580	44	active	active	JJ
cord-001835-0s7ok4uw	4580	45	'	'	''
cord-001835-0s7ok4uw	4580	46	state	state	NN
cord-001835-0s7ok4uw	4580	47	)	)	-RRB-
cord-001835-0s7ok4uw	4580	48	are	be	VBP
cord-001835-0s7ok4uw	4580	49	required	require	VBN
cord-001835-0s7ok4uw	4580	50	in	in	IN
cord-001835-0s7ok4uw	4580	51	order	order	NN
cord-001835-0s7ok4uw	4580	52	for	for	IN
cord-001835-0s7ok4uw	4580	53	transcription	transcription	NN
cord-001835-0s7ok4uw	4580	54	to	to	TO
cord-001835-0s7ok4uw	4580	55	take	take	VB
cord-001835-0s7ok4uw	4580	56	place	place	NN
cord-001835-0s7ok4uw	4580	57	.	.	.
cord-001835-0s7ok4uw	4581	1	In	in	IN
cord-001835-0s7ok4uw	4581	2	particular	particular	JJ
cord-001835-0s7ok4uw	4581	3	,	,	,
cord-001835-0s7ok4uw	4581	4	post	post	JJ
cord-001835-0s7ok4uw	4581	5	-	-	JJ
cord-001835-0s7ok4uw	4581	6	translational	translational	JJ
cord-001835-0s7ok4uw	4581	7	modifications	modification	NNS
cord-001835-0s7ok4uw	4581	8	(	(	-LRB-
cord-001835-0s7ok4uw	4581	9	PTMs	ptm	NNS
cord-001835-0s7ok4uw	4581	10	)	)	-RRB-
cord-001835-0s7ok4uw	4581	11	to	to	IN
cord-001835-0s7ok4uw	4581	12	histones	histone	NNS
cord-001835-0s7ok4uw	4581	13	have	have	VBP
cord-001835-0s7ok4uw	4581	14	an	an	DT
cord-001835-0s7ok4uw	4581	15	important	important	JJ
cord-001835-0s7ok4uw	4581	16	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	4581	17	function	function	NN
cord-001835-0s7ok4uw	4581	18	in	in	IN
cord-001835-0s7ok4uw	4581	19	gene	gene	NN
cord-001835-0s7ok4uw	4581	20	expression	expression	NN
cord-001835-0s7ok4uw	4581	21	under	under	IN
cord-001835-0s7ok4uw	4581	22	hypoxic	hypoxic	JJ
cord-001835-0s7ok4uw	4581	23	conditions	condition	NNS
cord-001835-0s7ok4uw	4581	24	.	.	.
cord-001835-0s7ok4uw	4582	1	The	the	DT
cord-001835-0s7ok4uw	4582	2	N	n	CD
cord-001835-0s7ok4uw	4582	3	-	-	HYPH
cord-001835-0s7ok4uw	4582	4	terminal	terminal	NN
cord-001835-0s7ok4uw	4582	5	tails	tail	NNS
cord-001835-0s7ok4uw	4582	6	of	of	IN
cord-001835-0s7ok4uw	4582	7	histone	histone	NN
cord-001835-0s7ok4uw	4582	8	proteins	protein	NNS
cord-001835-0s7ok4uw	4582	9	are	be	VBP
cord-001835-0s7ok4uw	4582	10	accessible	accessible	JJ
cord-001835-0s7ok4uw	4582	11	to	to	IN
cord-001835-0s7ok4uw	4582	12	a	a	DT
cord-001835-0s7ok4uw	4582	13	set	set	NN
cord-001835-0s7ok4uw	4582	14	of	of	IN
cord-001835-0s7ok4uw	4582	15	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4582	16	capable	capable	JJ
cord-001835-0s7ok4uw	4582	17	of	of	IN
cord-001835-0s7ok4uw	4582	18	'	'	``
cord-001835-0s7ok4uw	4582	19	writing	writing	NN
cord-001835-0s7ok4uw	4582	20	'	'	''
cord-001835-0s7ok4uw	4582	21	and	and	CC
cord-001835-0s7ok4uw	4582	22	'	'	``
cord-001835-0s7ok4uw	4582	23	erasing	erase	VBG
cord-001835-0s7ok4uw	4582	24	'	'	''
cord-001835-0s7ok4uw	4582	25	PTMs	ptm	NNS
cord-001835-0s7ok4uw	4582	26	including	include	VBG
cord-001835-0s7ok4uw	4582	27	acetylation	acetylation	NN
cord-001835-0s7ok4uw	4582	28	,	,	,
cord-001835-0s7ok4uw	4582	29	methylation	methylation	NN
cord-001835-0s7ok4uw	4582	30	,	,	,
cord-001835-0s7ok4uw	4582	31	ubiquitylation	ubiquitylation	NN
cord-001835-0s7ok4uw	4582	32	,	,	,
cord-001835-0s7ok4uw	4582	33	SUMOylation	sumoylation	NN
cord-001835-0s7ok4uw	4582	34	and	and	CC
cord-001835-0s7ok4uw	4582	35	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4582	36	.	.	.
cord-001835-0s7ok4uw	4583	1	To	to	IN
cord-001835-0s7ok4uw	4583	2	date	date	NN
cord-001835-0s7ok4uw	4583	3	,	,	,
cord-001835-0s7ok4uw	4583	4	studies	study	NNS
cord-001835-0s7ok4uw	4583	5	in	in	IN
cord-001835-0s7ok4uw	4583	6	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	4583	7	have	have	VBP
cord-001835-0s7ok4uw	4583	8	employed	employ	VBN
cord-001835-0s7ok4uw	4583	9	antibody	antibody	NN
cord-001835-0s7ok4uw	4583	10	-	-	HYPH
cord-001835-0s7ok4uw	4583	11	based	base	VBN
cord-001835-0s7ok4uw	4583	12	methods	method	NNS
cord-001835-0s7ok4uw	4583	13	to	to	TO
cord-001835-0s7ok4uw	4583	14	investigate	investigate	VB
cord-001835-0s7ok4uw	4583	15	changes	change	NNS
cord-001835-0s7ok4uw	4583	16	in	in	IN
cord-001835-0s7ok4uw	4583	17	histone	histone	JJ
cord-001835-0s7ok4uw	4583	18	modifications	modification	NNS
cord-001835-0s7ok4uw	4583	19	,	,	,
cord-001835-0s7ok4uw	4583	20	and	and	CC
cord-001835-0s7ok4uw	4583	21	so	so	RB
cord-001835-0s7ok4uw	4583	22	have	have	VBP
cord-001835-0s7ok4uw	4583	23	focused	focus	VBN
cord-001835-0s7ok4uw	4583	24	on	on	IN
cord-001835-0s7ok4uw	4583	25	individual	individual	JJ
cord-001835-0s7ok4uw	4583	26	marks	mark	NNS
cord-001835-0s7ok4uw	4583	27	in	in	IN
cord-001835-0s7ok4uw	4583	28	isolation	isolation	NN
cord-001835-0s7ok4uw	4583	29	.	.	.
cord-001835-0s7ok4uw	4584	1	The	the	DT
cord-001835-0s7ok4uw	4584	2	interplay	interplay	NN
cord-001835-0s7ok4uw	4584	3	between	between	IN
cord-001835-0s7ok4uw	4584	4	coexisting	coexist	VBG
cord-001835-0s7ok4uw	4584	5	PTMs	ptm	NNS
cord-001835-0s7ok4uw	4584	6	is	be	VBZ
cord-001835-0s7ok4uw	4584	7	thought	think	VBN
cord-001835-0s7ok4uw	4584	8	to	to	TO
cord-001835-0s7ok4uw	4584	9	be	be	VB
cord-001835-0s7ok4uw	4584	10	much	much	RB
cord-001835-0s7ok4uw	4584	11	more	more	RBR
cord-001835-0s7ok4uw	4584	12	important	important	JJ
cord-001835-0s7ok4uw	4584	13	than	than	IN
cord-001835-0s7ok4uw	4584	14	the	the	DT
cord-001835-0s7ok4uw	4584	15	effect	effect	NN
cord-001835-0s7ok4uw	4584	16	of	of	IN
cord-001835-0s7ok4uw	4584	17	any	any	DT
cord-001835-0s7ok4uw	4584	18	single	single	JJ
cord-001835-0s7ok4uw	4584	19	mark	mark	NN
cord-001835-0s7ok4uw	4584	20	.	.	.
cord-001835-0s7ok4uw	4585	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	4585	2	,	,	,
cord-001835-0s7ok4uw	4585	3	a	a	DT
cord-001835-0s7ok4uw	4585	4	global	global	JJ
cord-001835-0s7ok4uw	4585	5	view	view	NN
cord-001835-0s7ok4uw	4585	6	of	of	IN
cord-001835-0s7ok4uw	4585	7	the	the	DT
cord-001835-0s7ok4uw	4585	8	histone	histone	NN
cord-001835-0s7ok4uw	4585	9	modification	modification	NN
cord-001835-0s7ok4uw	4585	10	profile	profile	NN
cord-001835-0s7ok4uw	4585	11	is	be	VBZ
cord-001835-0s7ok4uw	4585	12	essential	essential	JJ
cord-001835-0s7ok4uw	4585	13	to	to	TO
cord-001835-0s7ok4uw	4585	14	gain	gain	VB
cord-001835-0s7ok4uw	4585	15	a	a	DT
cord-001835-0s7ok4uw	4585	16	complete	complete	JJ
cord-001835-0s7ok4uw	4585	17	understanding	understanding	NN
cord-001835-0s7ok4uw	4585	18	of	of	IN
cord-001835-0s7ok4uw	4585	19	the	the	DT
cord-001835-0s7ok4uw	4585	20	function	function	NN
cord-001835-0s7ok4uw	4585	21	of	of	IN
cord-001835-0s7ok4uw	4585	22	histone	histone	NN
cord-001835-0s7ok4uw	4585	23	PTMs	ptm	NNS
cord-001835-0s7ok4uw	4585	24	and	and	CC
cord-001835-0s7ok4uw	4585	25	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4585	26	roles	role	NNS
cord-001835-0s7ok4uw	4585	27	in	in	IN
cord-001835-0s7ok4uw	4585	28	gene	gene	NN
cord-001835-0s7ok4uw	4585	29	regulation	regulation	NN
cord-001835-0s7ok4uw	4585	30	.	.	.
cord-001835-0s7ok4uw	4586	1	In	in	IN
cord-001835-0s7ok4uw	4586	2	this	this	DT
cord-001835-0s7ok4uw	4586	3	study	study	NN
cord-001835-0s7ok4uw	4586	4	,	,	,
cord-001835-0s7ok4uw	4586	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4586	6	apply	apply	VBP
cord-001835-0s7ok4uw	4586	7	whole	whole	JJ
cord-001835-0s7ok4uw	4586	8	protein	protein	NN
cord-001835-0s7ok4uw	4586	9	mass	mass	NN
cord-001835-0s7ok4uw	4586	10	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4586	11	to	to	TO
cord-001835-0s7ok4uw	4586	12	investigate	investigate	VB
cord-001835-0s7ok4uw	4586	13	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	4586	14	-	-	HYPH
cord-001835-0s7ok4uw	4586	15	induced	induce	VBN
cord-001835-0s7ok4uw	4586	16	changes	change	NNS
cord-001835-0s7ok4uw	4586	17	in	in	IN
cord-001835-0s7ok4uw	4586	18	histone	histone	NN
cord-001835-0s7ok4uw	4586	19	marks	mark	NNS
cord-001835-0s7ok4uw	4586	20	.	.	.
cord-001835-0s7ok4uw	4587	1	This	this	DT
cord-001835-0s7ok4uw	4587	2	'	'	``
cord-001835-0s7ok4uw	4587	3	top	top	JJ
cord-001835-0s7ok4uw	4587	4	-	-	HYPH
cord-001835-0s7ok4uw	4587	5	down	down	NN
cord-001835-0s7ok4uw	4587	6	'	'	''
cord-001835-0s7ok4uw	4587	7	approach	approach	NN
cord-001835-0s7ok4uw	4587	8	provides	provide	VBZ
cord-001835-0s7ok4uw	4587	9	insight	insight	NN
cord-001835-0s7ok4uw	4587	10	into	into	IN
cord-001835-0s7ok4uw	4587	11	combinational	combinational	JJ
cord-001835-0s7ok4uw	4587	12	modification	modification	NN
cord-001835-0s7ok4uw	4587	13	patterns	pattern	NNS
cord-001835-0s7ok4uw	4587	14	that	that	WDT
cord-001835-0s7ok4uw	4587	15	are	be	VBP
cord-001835-0s7ok4uw	4587	16	difficult	difficult	JJ
cord-001835-0s7ok4uw	4587	17	to	to	TO
cord-001835-0s7ok4uw	4587	18	establish	establish	VB
cord-001835-0s7ok4uw	4587	19	by	by	IN
cord-001835-0s7ok4uw	4587	20	antibody	antibody	NN
cord-001835-0s7ok4uw	4587	21	-	-	HYPH
cord-001835-0s7ok4uw	4587	22	based	base	VBN
cord-001835-0s7ok4uw	4587	23	methods	method	NNS
cord-001835-0s7ok4uw	4587	24	or	or	CC
cord-001835-0s7ok4uw	4587	25	peptide	peptide	NN
cord-001835-0s7ok4uw	4587	26	MS	MS	NNP
cord-001835-0s7ok4uw	4587	27	analysis	analysis	NN
cord-001835-0s7ok4uw	4587	28	.	.	.
cord-001835-0s7ok4uw	4588	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4588	2	investigated	investigate	VBD
cord-001835-0s7ok4uw	4588	3	changes	change	NNS
cord-001835-0s7ok4uw	4588	4	in	in	IN
cord-001835-0s7ok4uw	4588	5	the	the	DT
cord-001835-0s7ok4uw	4588	6	global	global	JJ
cord-001835-0s7ok4uw	4588	7	PTM	PTM	NNP
cord-001835-0s7ok4uw	4588	8	profiles	profile	NNS
cord-001835-0s7ok4uw	4588	9	of	of	IN
cord-001835-0s7ok4uw	4588	10	histones	histone	NNS
cord-001835-0s7ok4uw	4588	11	from	from	IN
cord-001835-0s7ok4uw	4588	12	a	a	DT
cord-001835-0s7ok4uw	4588	13	range	range	NN
cord-001835-0s7ok4uw	4588	14	of	of	IN
cord-001835-0s7ok4uw	4588	15	human	human	JJ
cord-001835-0s7ok4uw	4588	16	cell	cell	NN
cord-001835-0s7ok4uw	4588	17	-	-	HYPH
cord-001835-0s7ok4uw	4588	18	lines	line	NNS
cord-001835-0s7ok4uw	4588	19	and	and	CC
cord-001835-0s7ok4uw	4588	20	tissues	tissue	NNS
cord-001835-0s7ok4uw	4588	21	under	under	IN
cord-001835-0s7ok4uw	4588	22	severe	severe	JJ
cord-001835-0s7ok4uw	4588	23	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	4588	24	(	(	-LRB-
cord-001835-0s7ok4uw	4588	25	<	<	XX
cord-001835-0s7ok4uw	4588	26	0.1	0.1	CD
cord-001835-0s7ok4uw	4588	27	%	%	NN
cord-001835-0s7ok4uw	4588	28	O2	o2	NN
cord-001835-0s7ok4uw	4588	29	)	)	-RRB-
cord-001835-0s7ok4uw	4588	30	.	.	.
cord-001835-0s7ok4uw	4589	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4589	2	find	find	VBP
cord-001835-0s7ok4uw	4589	3	that	that	IN
cord-001835-0s7ok4uw	4589	4	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	4589	5	causes	cause	VBZ
cord-001835-0s7ok4uw	4589	6	a	a	DT
cord-001835-0s7ok4uw	4589	7	shift	shift	NN
cord-001835-0s7ok4uw	4589	8	in	in	IN
cord-001835-0s7ok4uw	4589	9	the	the	DT
cord-001835-0s7ok4uw	4589	10	overall	overall	JJ
cord-001835-0s7ok4uw	4589	11	profile	profile	NN
cord-001835-0s7ok4uw	4589	12	towards	towards	IN
cord-001835-0s7ok4uw	4589	13	a	a	DT
cord-001835-0s7ok4uw	4589	14	more	more	RBR
cord-001835-0s7ok4uw	4589	15	highly	highly	RB
cord-001835-0s7ok4uw	4589	16	modified	modify	VBN
cord-001835-0s7ok4uw	4589	17	state	state	NN
cord-001835-0s7ok4uw	4589	18	,	,	,
cord-001835-0s7ok4uw	4589	19	with	with	IN
cord-001835-0s7ok4uw	4589	20	significant	significant	JJ
cord-001835-0s7ok4uw	4589	21	changes	change	NNS
cord-001835-0s7ok4uw	4589	22	in	in	IN
cord-001835-0s7ok4uw	4589	23	methylation	methylation	NN
cord-001835-0s7ok4uw	4589	24	and	and	CC
cord-001835-0s7ok4uw	4589	25	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4589	26	.	.	.
cord-001835-0s7ok4uw	4590	1	Marked	marked	JJ
cord-001835-0s7ok4uw	4590	2	changes	change	NNS
cord-001835-0s7ok4uw	4590	3	in	in	IN
cord-001835-0s7ok4uw	4590	4	histone	histone	NN
cord-001835-0s7ok4uw	4590	5	PTMs	ptm	NNS
cord-001835-0s7ok4uw	4590	6	were	be	VBD
cord-001835-0s7ok4uw	4590	7	also	also	RB
cord-001835-0s7ok4uw	4590	8	observed	observe	VBN
cord-001835-0s7ok4uw	4590	9	following	follow	VBG
cord-001835-0s7ok4uw	4590	10	treatment	treatment	NN
cord-001835-0s7ok4uw	4590	11	of	of	IN
cord-001835-0s7ok4uw	4590	12	cells	cell	NNS
cord-001835-0s7ok4uw	4590	13	with	with	IN
cord-001835-0s7ok4uw	4590	14	epigenetic	epigenetic	JJ
cord-001835-0s7ok4uw	4590	15	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4590	16	and	and	CC
cord-001835-0s7ok4uw	4590	17	commonly	commonly	RB
cord-001835-0s7ok4uw	4590	18	used	use	VBN
cord-001835-0s7ok4uw	4590	19	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	4590	20	mimetics	mimetic	NNS
cord-001835-0s7ok4uw	4590	21	,	,	,
cord-001835-0s7ok4uw	4590	22	including	include	VBG
cord-001835-0s7ok4uw	4590	23	several	several	JJ
cord-001835-0s7ok4uw	4590	24	iron	iron	NN
cord-001835-0s7ok4uw	4590	25	chelators	chelator	NNS
cord-001835-0s7ok4uw	4590	26	currently	currently	RB
cord-001835-0s7ok4uw	4590	27	in	in	IN
cord-001835-0s7ok4uw	4590	28	clinical	clinical	JJ
cord-001835-0s7ok4uw	4590	29	trials	trial	NNS
cord-001835-0s7ok4uw	4590	30	for	for	IN
cord-001835-0s7ok4uw	4590	31	the	the	DT
cord-001835-0s7ok4uw	4590	32	treatment	treatment	NN
cord-001835-0s7ok4uw	4590	33	of	of	IN
cord-001835-0s7ok4uw	4590	34	anaemia	anaemia	NN
cord-001835-0s7ok4uw	4590	35	.	.	.
cord-001835-0s7ok4uw	4591	1	Finally	finally	RB
cord-001835-0s7ok4uw	4591	2	,	,	,
cord-001835-0s7ok4uw	4591	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4591	4	show	show	VBP
cord-001835-0s7ok4uw	4591	5	that	that	IN
cord-001835-0s7ok4uw	4591	6	this	this	DT
cord-001835-0s7ok4uw	4591	7	method	method	NN
cord-001835-0s7ok4uw	4591	8	can	can	MD
cord-001835-0s7ok4uw	4591	9	be	be	VB
cord-001835-0s7ok4uw	4591	10	used	use	VBN
cord-001835-0s7ok4uw	4591	11	to	to	TO
cord-001835-0s7ok4uw	4591	12	identify	identify	VB
cord-001835-0s7ok4uw	4591	13	the	the	DT
cord-001835-0s7ok4uw	4591	14	histone	histone	NN
cord-001835-0s7ok4uw	4591	15	variant	variant	NN
cord-001835-0s7ok4uw	4591	16	H2AX	H2AX	NNP
cord-001835-0s7ok4uw	4591	17	,	,	,
cord-001835-0s7ok4uw	4591	18	whose	whose	WP$
cord-001835-0s7ok4uw	4591	19	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4591	20	at	at	IN
cord-001835-0s7ok4uw	4591	21	serine	serine	NN
cord-001835-0s7ok4uw	4591	22	139	139	CD
cord-001835-0s7ok4uw	4591	23	is	be	VBZ
cord-001835-0s7ok4uw	4591	24	an	an	DT
cord-001835-0s7ok4uw	4591	25	indicator	indicator	NN
cord-001835-0s7ok4uw	4591	26	of	of	IN
cord-001835-0s7ok4uw	4591	27	double	double	RB
cord-001835-0s7ok4uw	4591	28	-	-	HYPH
cord-001835-0s7ok4uw	4591	29	stranded	strand	VBN
cord-001835-0s7ok4uw	4591	30	DNA	dna	NN
cord-001835-0s7ok4uw	4591	31	breaks	break	NNS
cord-001835-0s7ok4uw	4591	32	in	in	IN
cord-001835-0s7ok4uw	4591	33	cancer	cancer	NN
cord-001835-0s7ok4uw	4591	34	.	.	.
cord-001835-0s7ok4uw	4592	1	Overall	overall	RB
cord-001835-0s7ok4uw	4592	2	,	,	,
cord-001835-0s7ok4uw	4592	3	these	these	DT
cord-001835-0s7ok4uw	4592	4	data	datum	NNS
cord-001835-0s7ok4uw	4592	5	provide	provide	VBP
cord-001835-0s7ok4uw	4592	6	important	important	JJ
cord-001835-0s7ok4uw	4592	7	insights	insight	NNS
cord-001835-0s7ok4uw	4592	8	into	into	IN
cord-001835-0s7ok4uw	4592	9	the	the	DT
cord-001835-0s7ok4uw	4592	10	epigenetic	epigenetic	JJ
cord-001835-0s7ok4uw	4592	11	changes	change	NNS
cord-001835-0s7ok4uw	4592	12	associated	associate	VBN
cord-001835-0s7ok4uw	4592	13	with	with	IN
cord-001835-0s7ok4uw	4592	14	hypoxia	hypoxia	NN
cord-001835-0s7ok4uw	4592	15	in	in	IN
cord-001835-0s7ok4uw	4592	16	normal	normal	JJ
cord-001835-0s7ok4uw	4592	17	and	and	CC
cord-001835-0s7ok4uw	4592	18	disease	disease	NN
cord-001835-0s7ok4uw	4592	19	contexts	context	NNS
cord-001835-0s7ok4uw	4592	20	.	.	.
cord-001835-0s7ok4uw	4593	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4593	2	hope	hope	VBP
cord-001835-0s7ok4uw	4593	3	to	to	TO
cord-001835-0s7ok4uw	4593	4	further	further	RB
cord-001835-0s7ok4uw	4593	5	develop	develop	VB
cord-001835-0s7ok4uw	4593	6	this	this	DT
cord-001835-0s7ok4uw	4593	7	method	method	NN
cord-001835-0s7ok4uw	4593	8	in	in	IN
cord-001835-0s7ok4uw	4593	9	combination	combination	NN
cord-001835-0s7ok4uw	4593	10	with	with	IN
cord-001835-0s7ok4uw	4593	11	different	different	JJ
cord-001835-0s7ok4uw	4593	12	labelling	labelling	NN
cord-001835-0s7ok4uw	4593	13	strategies	strategy	NNS
cord-001835-0s7ok4uw	4593	14	to	to	TO
cord-001835-0s7ok4uw	4593	15	enable	enable	VB
cord-001835-0s7ok4uw	4593	16	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	4593	17	analysis	analysis	NN
cord-001835-0s7ok4uw	4593	18	of	of	IN
cord-001835-0s7ok4uw	4593	19	histonemodifications	histonemodification	NNS
cord-001835-0s7ok4uw	4593	20	in	in	IN
cord-001835-0s7ok4uw	4593	21	cells	cell	NNS
cord-001835-0s7ok4uw	4593	22	.	.	.
cord-001835-0s7ok4uw	4594	1	Mass	mass	JJ
cord-001835-0s7ok4uw	4594	2	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4594	3	-	-	HYPH
cord-001835-0s7ok4uw	4594	4	based	base	VBN
cord-001835-0s7ok4uw	4594	5	protein	protein	NN
cord-001835-0s7ok4uw	4594	6	biomarker	biomarker	NN
cord-001835-0s7ok4uw	4594	7	discovery	discovery	NN
cord-001835-0s7ok4uw	4594	8	in	in	IN
cord-001835-0s7ok4uw	4594	9	neurodevelopmental	neurodevelopmental	JJ
cord-001835-0s7ok4uw	4594	10	disorders	disorder	NNS
cord-001835-0s7ok4uw	4594	11	interactions	interaction	NNS
cord-001835-0s7ok4uw	4594	12	.	.	.
cord-001835-0s7ok4uw	4595	1	There	there	EX
cord-001835-0s7ok4uw	4595	2	is	be	VBZ
cord-001835-0s7ok4uw	4595	3	currently	currently	RB
cord-001835-0s7ok4uw	4595	4	no	no	DT
cord-001835-0s7ok4uw	4595	5	biological	biological	JJ
cord-001835-0s7ok4uw	4595	6	diagnosis	diagnosis	NN
cord-001835-0s7ok4uw	4595	7	or	or	CC
cord-001835-0s7ok4uw	4595	8	known	know	VBN
cord-001835-0s7ok4uw	4595	9	cause	cause	NN
cord-001835-0s7ok4uw	4595	10	of	of	IN
cord-001835-0s7ok4uw	4595	11	ASD	ASD	NNP
cord-001835-0s7ok4uw	4595	12	.	.	.
cord-001835-0s7ok4uw	4596	1	SLOS	SLOS	NNP
cord-001835-0s7ok4uw	4596	2	is	be	VBZ
cord-001835-0s7ok4uw	4596	3	characterized	characterize	VBN
cord-001835-0s7ok4uw	4596	4	by	by	IN
cord-001835-0s7ok4uw	4596	5	a	a	DT
cord-001835-0s7ok4uw	4596	6	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	4596	7	deficiency	deficiency	NN
cord-001835-0s7ok4uw	4596	8	due	due	IN
cord-001835-0s7ok4uw	4596	9	to	to	IN
cord-001835-0s7ok4uw	4596	10	a	a	DT
cord-001835-0s7ok4uw	4596	11	mutation	mutation	NN
cord-001835-0s7ok4uw	4596	12	on	on	IN
cord-001835-0s7ok4uw	4596	13	the	the	DT
cord-001835-0s7ok4uw	4596	14	7DHCR	7dhcr	CD
cord-001835-0s7ok4uw	4596	15	gene	gene	NN
cord-001835-0s7ok4uw	4596	16	.	.	.
cord-001835-0s7ok4uw	4597	1	Approximately	approximately	RB
cord-001835-0s7ok4uw	4597	2	1/20,000	1/20,000	CD
cord-001835-0s7ok4uw	4597	3	babies	baby	NNS
cord-001835-0s7ok4uw	4597	4	are	be	VBP
cord-001835-0s7ok4uw	4597	5	born	bear	VBN
cord-001835-0s7ok4uw	4597	6	with	with	IN
cord-001835-0s7ok4uw	4597	7	SLOS	SLOS	NNP
cord-001835-0s7ok4uw	4597	8	.	.	.
cord-001835-0s7ok4uw	4598	1	Diagnosis	diagnosis	NN
cord-001835-0s7ok4uw	4598	2	is	be	VBZ
cord-001835-0s7ok4uw	4598	3	achieved	achieve	VBN
cord-001835-0s7ok4uw	4598	4	by	by	IN
cord-001835-0s7ok4uw	4598	5	measuring	measure	VBG
cord-001835-0s7ok4uw	4598	6	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	4598	7	and	and	CC
cord-001835-0s7ok4uw	4598	8	7-dehydrocholesterol	7-dehydrocholesterol	CD
cord-001835-0s7ok4uw	4598	9	(	(	-LRB-
cord-001835-0s7ok4uw	4598	10	7DHC	7dhc	NN
cord-001835-0s7ok4uw	4598	11	)	)	-RRB-
cord-001835-0s7ok4uw	4598	12	levels	level	NNS
cord-001835-0s7ok4uw	4598	13	in	in	IN
cord-001835-0s7ok4uw	4598	14	the	the	DT
cord-001835-0s7ok4uw	4598	15	blood	blood	NN
cord-001835-0s7ok4uw	4598	16	,	,	,
cord-001835-0s7ok4uw	4598	17	however	however	RB
cord-001835-0s7ok4uw	4598	18	,	,	,
cord-001835-0s7ok4uw	4598	19	there	there	EX
cord-001835-0s7ok4uw	4598	20	is	be	VBZ
cord-001835-0s7ok4uw	4598	21	currently	currently	RB
cord-001835-0s7ok4uw	4598	22	no	no	DT
cord-001835-0s7ok4uw	4598	23	proven	prove	VBN
cord-001835-0s7ok4uw	4598	24	treatment	treatment	NN
cord-001835-0s7ok4uw	4598	25	for	for	IN
cord-001835-0s7ok4uw	4598	26	SLOS	SLOS	NNP
cord-001835-0s7ok4uw	4598	27	.	.	.
cord-001835-0s7ok4uw	4599	1	Because	because	IN
cord-001835-0s7ok4uw	4599	2	of	of	IN
cord-001835-0s7ok4uw	4599	3	this	this	DT
cord-001835-0s7ok4uw	4599	4	,	,	,
cord-001835-0s7ok4uw	4599	5	research	research	NN
cord-001835-0s7ok4uw	4599	6	is	be	VBZ
cord-001835-0s7ok4uw	4599	7	increasing	increase	VBG
cord-001835-0s7ok4uw	4599	8	to	to	TO
cord-001835-0s7ok4uw	4599	9	determine	determine	VB
cord-001835-0s7ok4uw	4599	10	biomarkers	biomarker	NNS
cord-001835-0s7ok4uw	4599	11	for	for	IN
cord-001835-0s7ok4uw	4599	12	these	these	DT
cord-001835-0s7ok4uw	4599	13	disorders	disorder	NNS
cord-001835-0s7ok4uw	4599	14	.	.	.
cord-001835-0s7ok4uw	4600	1	Here	here	RB
cord-001835-0s7ok4uw	4600	2	,	,	,
cord-001835-0s7ok4uw	4600	3	samples	sample	NNS
cord-001835-0s7ok4uw	4600	4	from	from	IN
cord-001835-0s7ok4uw	4600	5	people	people	NNS
cord-001835-0s7ok4uw	4600	6	with	with	IN
cord-001835-0s7ok4uw	4600	7	ASD	ASD	NNP
cord-001835-0s7ok4uw	4600	8	(	(	-LRB-
cord-001835-0s7ok4uw	4600	9	sera	sera	NNP
cord-001835-0s7ok4uw	4600	10	and	and	CC
cord-001835-0s7ok4uw	4600	11	saliva	saliva	NN
cord-001835-0s7ok4uw	4600	12	)	)	-RRB-
cord-001835-0s7ok4uw	4600	13	and	and	CC
cord-001835-0s7ok4uw	4600	14	SLOS	SLOS	NNP
cord-001835-0s7ok4uw	4600	15	(	(	-LRB-
cord-001835-0s7ok4uw	4600	16	saliva	saliva	NN
cord-001835-0s7ok4uw	4600	17	)	)	-RRB-
cord-001835-0s7ok4uw	4600	18	,	,	,
cord-001835-0s7ok4uw	4600	19	and	and	CC
cord-001835-0s7ok4uw	4600	20	matched	match	VBN
cord-001835-0s7ok4uw	4600	21	controls	control	NNS
cord-001835-0s7ok4uw	4600	22	were	be	VBD
cord-001835-0s7ok4uw	4600	23	analyzed	analyze	VBN
cord-001835-0s7ok4uw	4600	24	using	use	VBG
cord-001835-0s7ok4uw	4600	25	a	a	DT
cord-001835-0s7ok4uw	4600	26	combination	combination	NN
cord-001835-0s7ok4uw	4600	27	of	of	IN
cord-001835-0s7ok4uw	4600	28	gel	gel	NN
cord-001835-0s7ok4uw	4600	29	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	4600	30	(	(	-LRB-
cord-001835-0s7ok4uw	4600	31	Tricine	Tricine	NNP
cord-001835-0s7ok4uw	4600	32	-	-	HYPH
cord-001835-0s7ok4uw	4600	33	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	4600	34	,	,	,
cord-001835-0s7ok4uw	4600	35	SDS	SDS	NNP
cord-001835-0s7ok4uw	4600	36	-	-	HYPH
cord-001835-0s7ok4uw	4600	37	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	4600	38	and	and	CC
cord-001835-0s7ok4uw	4600	39	Blue	Blue	NNP
cord-001835-0s7ok4uw	4600	40	Native	Native	NNP
cord-001835-0s7ok4uw	4600	41	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	4600	42	)	)	-RRB-
cord-001835-0s7ok4uw	4600	43	,	,	,
cord-001835-0s7ok4uw	4600	44	in	in	IN
cord-001835-0s7ok4uw	4600	45	gel	gel	NN
cord-001835-0s7ok4uw	4600	46	digestion	digestion	NN
cord-001835-0s7ok4uw	4600	47	or	or	CC
cord-001835-0s7ok4uw	4600	48	insolution	insolution	NN
cord-001835-0s7ok4uw	4600	49	digestion	digestion	NN
cord-001835-0s7ok4uw	4600	50	and	and	CC
cord-001835-0s7ok4uw	4600	51	nanoliquid	nanoliquid	NNP
cord-001835-0s7ok4uw	4600	52	chromatography	chromatography	NN
cord-001835-0s7ok4uw	4600	53	-	-	HYPH
cord-001835-0s7ok4uw	4600	54	tandem	tandem	NN
cord-001835-0s7ok4uw	4600	55	mass	mass	NN
cord-001835-0s7ok4uw	4600	56	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4600	57	(	(	-LRB-
cord-001835-0s7ok4uw	4600	58	nanolC	nanolC	NNP
cord-001835-0s7ok4uw	4600	59	-	-	HYPH
cord-001835-0s7ok4uw	4600	60	MS	MS	NNP
cord-001835-0s7ok4uw	4600	61	/	/	SYM
cord-001835-0s7ok4uw	4600	62	MS	MS	NNP
cord-001835-0s7ok4uw	4600	63	)	)	-RRB-
cord-001835-0s7ok4uw	4600	64	to	to	TO
cord-001835-0s7ok4uw	4600	65	investigate	investigate	VB
cord-001835-0s7ok4uw	4600	66	differences	difference	NNS
cord-001835-0s7ok4uw	4600	67	between	between	IN
cord-001835-0s7ok4uw	4600	68	the	the	DT
cord-001835-0s7ok4uw	4600	69	proteomes	proteome	NNS
cord-001835-0s7ok4uw	4600	70	of	of	IN
cord-001835-0s7ok4uw	4600	71	people	people	NNS
cord-001835-0s7ok4uw	4600	72	with	with	IN
cord-001835-0s7ok4uw	4600	73	these	these	DT
cord-001835-0s7ok4uw	4600	74	neurodevelopmental	neurodevelopmental	JJ
cord-001835-0s7ok4uw	4600	75	disorders	disorder	NNS
cord-001835-0s7ok4uw	4600	76	and	and	CC
cord-001835-0s7ok4uw	4600	77	matched	match	VBN
cord-001835-0s7ok4uw	4600	78	controls	control	NNS
cord-001835-0s7ok4uw	4600	79	.	.	.
cord-001835-0s7ok4uw	4601	1	Several	several	JJ
cord-001835-0s7ok4uw	4601	2	alterations	alteration	NNS
cord-001835-0s7ok4uw	4601	3	in	in	IN
cord-001835-0s7ok4uw	4601	4	protein	protein	NN
cord-001835-0s7ok4uw	4601	5	expression	expression	NN
cord-001835-0s7ok4uw	4601	6	were	be	VBD
cord-001835-0s7ok4uw	4601	7	identified	identify	VBN
cord-001835-0s7ok4uw	4601	8	.	.	.
cord-001835-0s7ok4uw	4602	1	These	these	DT
cord-001835-0s7ok4uw	4602	2	differences	difference	NNS
cord-001835-0s7ok4uw	4602	3	may	may	MD
cord-001835-0s7ok4uw	4602	4	lead	lead	VB
cord-001835-0s7ok4uw	4602	5	to	to	IN
cord-001835-0s7ok4uw	4602	6	potential	potential	JJ
cord-001835-0s7ok4uw	4602	7	biomarkers	biomarker	NNS
cord-001835-0s7ok4uw	4602	8	for	for	IN
cord-001835-0s7ok4uw	4602	9	diagnosis	diagnosis	NN
cord-001835-0s7ok4uw	4602	10	,	,	,
cord-001835-0s7ok4uw	4602	11	possible	possible	JJ
cord-001835-0s7ok4uw	4602	12	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	4602	13	targets	target	NNS
cord-001835-0s7ok4uw	4602	14	and	and	CC
cord-001835-0s7ok4uw	4602	15	an	an	DT
cord-001835-0s7ok4uw	4602	16	altogether	altogether	RB
cord-001835-0s7ok4uw	4602	17	better	well	JJR
cord-001835-0s7ok4uw	4602	18	understanding	understanding	NN
cord-001835-0s7ok4uw	4602	19	of	of	IN
cord-001835-0s7ok4uw	4602	20	the	the	DT
cord-001835-0s7ok4uw	4602	21	disorders	disorder	NNS
cord-001835-0s7ok4uw	4602	22	.	.	.
cord-001835-0s7ok4uw	4603	1	Understanding	understand	VBG
cord-001835-0s7ok4uw	4603	2	protein	protein	NN
cord-001835-0s7ok4uw	4603	3	recognition	recognition	NN
cord-001835-0s7ok4uw	4603	4	using	use	VBG
cord-001835-0s7ok4uw	4603	5	structural	structural	JJ
cord-001835-0s7ok4uw	4603	6	features	feature	VBZ
cord-001835-0s7ok4uw	4603	7	Protein	Protein	NNP
cord-001835-0s7ok4uw	4603	8	-	-	HYPH
cord-001835-0s7ok4uw	4603	9	Protein	Protein	NNP
cord-001835-0s7ok4uw	4603	10	interactions	interaction	NNS
cord-001835-0s7ok4uw	4603	11	(	(	-LRB-
cord-001835-0s7ok4uw	4603	12	PPIs	ppi	NNS
cord-001835-0s7ok4uw	4603	13	)	)	-RRB-
cord-001835-0s7ok4uw	4603	14	play	play	VBP
cord-001835-0s7ok4uw	4603	15	a	a	DT
cord-001835-0s7ok4uw	4603	16	crucial	crucial	JJ
cord-001835-0s7ok4uw	4603	17	role	role	NN
cord-001835-0s7ok4uw	4603	18	in	in	IN
cord-001835-0s7ok4uw	4603	19	virtually	virtually	RB
cord-001835-0s7ok4uw	4603	20	all	all	DT
cord-001835-0s7ok4uw	4603	21	cell	cell	NN
cord-001835-0s7ok4uw	4603	22	processes	process	NNS
cord-001835-0s7ok4uw	4603	23	.	.	.
cord-001835-0s7ok4uw	4604	1	Thus	thus	RB
cord-001835-0s7ok4uw	4604	2	,	,	,
cord-001835-0s7ok4uw	4604	3	understanding	understand	VBG
cord-001835-0s7ok4uw	4604	4	the	the	DT
cord-001835-0s7ok4uw	4604	5	molecular	molecular	JJ
cord-001835-0s7ok4uw	4604	6	mechanism	mechanism	NN
cord-001835-0s7ok4uw	4604	7	of	of	IN
cord-001835-0s7ok4uw	4604	8	protein	protein	NN
cord-001835-0s7ok4uw	4604	9	recognition	recognition	NN
cord-001835-0s7ok4uw	4604	10	is	be	VBZ
cord-001835-0s7ok4uw	4604	11	a	a	DT
cord-001835-0s7ok4uw	4604	12	critical	critical	JJ
cord-001835-0s7ok4uw	4604	13	challenge	challenge	NN
cord-001835-0s7ok4uw	4604	14	in	in	IN
cord-001835-0s7ok4uw	4604	15	molecular	molecular	JJ
cord-001835-0s7ok4uw	4604	16	biology	biology	NN
cord-001835-0s7ok4uw	4604	17	.	.	.
cord-001835-0s7ok4uw	4605	1	Previous	previous	JJ
cord-001835-0s7ok4uw	4605	2	works	work	NNS
cord-001835-0s7ok4uw	4605	3	in	in	IN
cord-001835-0s7ok4uw	4605	4	this	this	DT
cord-001835-0s7ok4uw	4605	5	field	field	NN
cord-001835-0s7ok4uw	4605	6	show	show	VBP
cord-001835-0s7ok4uw	4605	7	that	that	IN
cord-001835-0s7ok4uw	4605	8	not	not	RB
cord-001835-0s7ok4uw	4605	9	only	only	RB
cord-001835-0s7ok4uw	4605	10	the	the	DT
cord-001835-0s7ok4uw	4605	11	binding	bind	VBG
cord-001835-0s7ok4uw	4605	12	region	region	NN
cord-001835-0s7ok4uw	4605	13	but	but	CC
cord-001835-0s7ok4uw	4605	14	also	also	RB
cord-001835-0s7ok4uw	4605	15	the	the	DT
cord-001835-0s7ok4uw	4605	16	rest	rest	NN
cord-001835-0s7ok4uw	4605	17	of	of	IN
cord-001835-0s7ok4uw	4605	18	the	the	DT
cord-001835-0s7ok4uw	4605	19	protein	protein	NN
cord-001835-0s7ok4uw	4605	20	is	be	VBZ
cord-001835-0s7ok4uw	4605	21	involved	involve	VBN
cord-001835-0s7ok4uw	4605	22	in	in	IN
cord-001835-0s7ok4uw	4605	23	the	the	DT
cord-001835-0s7ok4uw	4605	24	interaction	interaction	NN
cord-001835-0s7ok4uw	4605	25	,	,	,
cord-001835-0s7ok4uw	4605	26	suggesting	suggest	VBG
cord-001835-0s7ok4uw	4605	27	a	a	DT
cord-001835-0s7ok4uw	4605	28	funnel	funnel	NN
cord-001835-0s7ok4uw	4605	29	-	-	HYPH
cord-001835-0s7ok4uw	4605	30	like	like	JJ
cord-001835-0s7ok4uw	4605	31	recognition	recognition	NN
cord-001835-0s7ok4uw	4605	32	model	model	NN
cord-001835-0s7ok4uw	4605	33	as	as	IN
cord-001835-0s7ok4uw	4605	34	responsible	responsible	JJ
cord-001835-0s7ok4uw	4605	35	of	of	IN
cord-001835-0s7ok4uw	4605	36	facilitating	facilitate	VBG
cord-001835-0s7ok4uw	4605	37	the	the	DT
cord-001835-0s7ok4uw	4605	38	interacting	interact	VBG
cord-001835-0s7ok4uw	4605	39	process	process	NN
cord-001835-0s7ok4uw	4605	40	.	.	.
cord-001835-0s7ok4uw	4606	1	Further	further	RB
cord-001835-0s7ok4uw	4606	2	more	more	JJR
cord-001835-0s7ok4uw	4606	3	,	,	,
cord-001835-0s7ok4uw	4606	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	4606	5	have	have	VBP
cord-001835-0s7ok4uw	4606	6	previously	previously	RB
cord-001835-0s7ok4uw	4606	7	shown	show	VBN
cord-001835-0s7ok4uw	4606	8	that	that	IN
cord-001835-0s7ok4uw	4606	9	three	three	CD
cord-001835-0s7ok4uw	4606	10	-	-	HYPH
cord-001835-0s7ok4uw	4606	11	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	4606	12	local	local	JJ
cord-001835-0s7ok4uw	4606	13	structural	structural	JJ
cord-001835-0s7ok4uw	4606	14	features	feature	NNS
cord-001835-0s7ok4uw	4606	15	(	(	-LRB-
cord-001835-0s7ok4uw	4606	16	groups	group	NNS
cord-001835-0s7ok4uw	4606	17	of	of	IN
cord-001835-0s7ok4uw	4606	18	protein	protein	NN
cord-001835-0s7ok4uw	4606	19	loops	loop	NNS
cord-001835-0s7ok4uw	4606	20	)	)	-RRB-
cord-001835-0s7ok4uw	4606	21	define	define	VB
cord-001835-0s7ok4uw	4606	22	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	4606	23	patterns	pattern	NNS
cord-001835-0s7ok4uw	4606	24	(	(	-LRB-
cord-001835-0s7ok4uw	4606	25	interaction	interaction	NN
cord-001835-0s7ok4uw	4606	26	signatures	signature	NNS
cord-001835-0s7ok4uw	4606	27	)	)	-RRB-
cord-001835-0s7ok4uw	4606	28	that	that	WDT
cord-001835-0s7ok4uw	4606	29	can	can	MD
cord-001835-0s7ok4uw	4606	30	be	be	VB
cord-001835-0s7ok4uw	4606	31	used	use	VBN
cord-001835-0s7ok4uw	4606	32	to	to	TO
cord-001835-0s7ok4uw	4606	33	predict	predict	VB
cord-001835-0s7ok4uw	4606	34	whether	whether	IN
cord-001835-0s7ok4uw	4606	35	two	two	CD
cord-001835-0s7ok4uw	4606	36	proteins	protein	NNS
cord-001835-0s7ok4uw	4606	37	will	will	MD
cord-001835-0s7ok4uw	4606	38	interact	interact	VB
cord-001835-0s7ok4uw	4606	39	or	or	CC
cord-001835-0s7ok4uw	4606	40	not	not	RB
cord-001835-0s7ok4uw	4606	41	.	.	.
cord-001835-0s7ok4uw	4607	1	A	a	DT
cord-001835-0s7ok4uw	4607	2	notable	notable	JJ
cord-001835-0s7ok4uw	4607	3	trait	trait	NN
cord-001835-0s7ok4uw	4607	4	of	of	IN
cord-001835-0s7ok4uw	4607	5	this	this	DT
cord-001835-0s7ok4uw	4607	6	prediction	prediction	NN
cord-001835-0s7ok4uw	4607	7	system	system	NN
cord-001835-0s7ok4uw	4607	8	is	be	VBZ
cord-001835-0s7ok4uw	4607	9	that	that	IN
cord-001835-0s7ok4uw	4607	10	interaction	interaction	NN
cord-001835-0s7ok4uw	4607	11	signatures	signature	NNS
cord-001835-0s7ok4uw	4607	12	can	can	MD
cord-001835-0s7ok4uw	4607	13	be	be	VB
cord-001835-0s7ok4uw	4607	14	denoted	denote	VBN
cord-001835-0s7ok4uw	4607	15	as	as	IN
cord-001835-0s7ok4uw	4607	16	favouring	favour	VBG
cord-001835-0s7ok4uw	4607	17	or	or	CC
cord-001835-0s7ok4uw	4607	18	disfavouring	disfavour	VBG
cord-001835-0s7ok4uw	4607	19	depending	depend	VBG
cord-001835-0s7ok4uw	4607	20	on	on	IN
cord-001835-0s7ok4uw	4607	21	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4607	22	role	role	NN
cord-001835-0s7ok4uw	4607	23	on	on	IN
cord-001835-0s7ok4uw	4607	24	the	the	DT
cord-001835-0s7ok4uw	4607	25	promotion	promotion	NN
cord-001835-0s7ok4uw	4607	26	of	of	IN
cord-001835-0s7ok4uw	4607	27	the	the	DT
cord-001835-0s7ok4uw	4607	28	molecular	molecular	JJ
cord-001835-0s7ok4uw	4607	29	binding	binding	NN
cord-001835-0s7ok4uw	4607	30	.	.	.
cord-001835-0s7ok4uw	4608	1	Here	here	RB
cord-001835-0s7ok4uw	4608	2	,	,	,
cord-001835-0s7ok4uw	4608	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4608	4	use	use	VBP
cord-001835-0s7ok4uw	4608	5	such	such	JJ
cord-001835-0s7ok4uw	4608	6	features	feature	NNS
cord-001835-0s7ok4uw	4608	7	in	in	IN
cord-001835-0s7ok4uw	4608	8	order	order	NN
cord-001835-0s7ok4uw	4608	9	to	to	TO
cord-001835-0s7ok4uw	4608	10	determine	determine	VB
cord-001835-0s7ok4uw	4608	11	differences	difference	NNS
cord-001835-0s7ok4uw	4608	12	between	between	IN
cord-001835-0s7ok4uw	4608	13	the	the	DT
cord-001835-0s7ok4uw	4608	14	binding	bind	VBG
cord-001835-0s7ok4uw	4608	15	interface	interface	NN
cord-001835-0s7ok4uw	4608	16	and	and	CC
cord-001835-0s7ok4uw	4608	17	the	the	DT
cord-001835-0s7ok4uw	4608	18	rest	rest	NN
cord-001835-0s7ok4uw	4608	19	of	of	IN
cord-001835-0s7ok4uw	4608	20	the	the	DT
cord-001835-0s7ok4uw	4608	21	protein	protein	NN
cord-001835-0s7ok4uw	4608	22	surface	surface	NN
cord-001835-0s7ok4uw	4608	23	in	in	IN
cord-001835-0s7ok4uw	4608	24	known	know	VBN
cord-001835-0s7ok4uw	4608	25	PPIs	ppi	NNS
cord-001835-0s7ok4uw	4608	26	.	.	.
cord-001835-0s7ok4uw	4609	1	Particularly	particularly	RB
cord-001835-0s7ok4uw	4609	2	,	,	,
cord-001835-0s7ok4uw	4609	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4609	4	study	study	VBP
cord-001835-0s7ok4uw	4609	5	computationally	computationally	RB
cord-001835-0s7ok4uw	4609	6	three	three	CD
cord-001835-0s7ok4uw	4609	7	different	different	JJ
cord-001835-0s7ok4uw	4609	8	groups	group	NNS
cord-001835-0s7ok4uw	4609	9	of	of	IN
cord-001835-0s7ok4uw	4609	10	protein	protein	NN
cord-001835-0s7ok4uw	4609	11	-	-	HYPH
cord-001835-0s7ok4uw	4609	12	protein	protein	NN
cord-001835-0s7ok4uw	4609	13	interfaces	interface	NNS
cord-001835-0s7ok4uw	4609	14	:	:	:
cord-001835-0s7ok4uw	4609	15	i	i	LS
cord-001835-0s7ok4uw	4609	16	)	)	-RRB-
cord-001835-0s7ok4uw	4609	17	native	native	JJ
cord-001835-0s7ok4uw	4609	18	interfaces	interface	NNS
cord-001835-0s7ok4uw	4609	19	(	(	-LRB-
cord-001835-0s7ok4uw	4609	20	the	the	DT
cord-001835-0s7ok4uw	4609	21	actual	actual	JJ
cord-001835-0s7ok4uw	4609	22	binding	bind	VBG
cord-001835-0s7ok4uw	4609	23	patches	patch	NNS
cord-001835-0s7ok4uw	4609	24	of	of	IN
cord-001835-0s7ok4uw	4609	25	the	the	DT
cord-001835-0s7ok4uw	4609	26	interacting	interact	VBG
cord-001835-0s7ok4uw	4609	27	pairs	pair	NNS
cord-001835-0s7ok4uw	4609	28	)	)	-RRB-
cord-001835-0s7ok4uw	4609	29	,	,	,
cord-001835-0s7ok4uw	4609	30	ii	ii	LS
cord-001835-0s7ok4uw	4609	31	)	)	-RRB-
cord-001835-0s7ok4uw	4609	32	partial	partial	JJ
cord-001835-0s7ok4uw	4609	33	interfaces	interface	NNS
cord-001835-0s7ok4uw	4609	34	(	(	-LRB-
cord-001835-0s7ok4uw	4609	35	the	the	DT
cord-001835-0s7ok4uw	4609	36	docking	docking	NN
cord-001835-0s7ok4uw	4609	37	between	between	IN
cord-001835-0s7ok4uw	4609	38	a	a	DT
cord-001835-0s7ok4uw	4609	39	binding	binding	JJ
cord-001835-0s7ok4uw	4609	40	patch	patch	NN
cord-001835-0s7ok4uw	4609	41	and	and	CC
cord-001835-0s7ok4uw	4609	42	a	a	DT
cord-001835-0s7ok4uw	4609	43	non	non	JJ
cord-001835-0s7ok4uw	4609	44	-	-	JJ
cord-001835-0s7ok4uw	4609	45	interacting	interacting	JJ
cord-001835-0s7ok4uw	4609	46	patch	patch	NN
cord-001835-0s7ok4uw	4609	47	)	)	-RRB-
cord-001835-0s7ok4uw	4609	48	,	,	,
cord-001835-0s7ok4uw	4609	49	and	and	CC
cord-001835-0s7ok4uw	4609	50	iii	iii	LS
cord-001835-0s7ok4uw	4609	51	)	)	-RRB-
cord-001835-0s7ok4uw	4609	52	back	back	NN
cord-001835-0s7ok4uw	4609	53	-	-	HYPH
cord-001835-0s7ok4uw	4609	54	to	to	IN
cord-001835-0s7ok4uw	4609	55	-	-	HYPH
cord-001835-0s7ok4uw	4609	56	back	back	NN
cord-001835-0s7ok4uw	4609	57	interfaces	interface	NNS
cord-001835-0s7ok4uw	4609	58	(	(	-LRB-
cord-001835-0s7ok4uw	4609	59	the	the	DT
cord-001835-0s7ok4uw	4609	60	docking	docking	NN
cord-001835-0s7ok4uw	4609	61	between	between	IN
cord-001835-0s7ok4uw	4609	62	non	non	JJ
cord-001835-0s7ok4uw	4609	63	-	-	JJ
cord-001835-0s7ok4uw	4609	64	interacting	interacting	JJ
cord-001835-0s7ok4uw	4609	65	patches	patch	NNS
cord-001835-0s7ok4uw	4609	66	for	for	IN
cord-001835-0s7ok4uw	4609	67	both	both	DT
cord-001835-0s7ok4uw	4609	68	of	of	IN
cord-001835-0s7ok4uw	4609	69	the	the	DT
cord-001835-0s7ok4uw	4609	70	interacting	interact	VBG
cord-001835-0s7ok4uw	4609	71	proteins	protein	NNS
cord-001835-0s7ok4uw	4609	72	)	)	-RRB-
cord-001835-0s7ok4uw	4609	73	.	.	.
cord-001835-0s7ok4uw	4610	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4610	2	results	result	NNS
cord-001835-0s7ok4uw	4610	3	show	show	VBP
cord-001835-0s7ok4uw	4610	4	that	that	IN
cord-001835-0s7ok4uw	4610	5	the	the	DT
cord-001835-0s7ok4uw	4610	6	interaction	interaction	NN
cord-001835-0s7ok4uw	4610	7	signatures	signature	NNS
cord-001835-0s7ok4uw	4610	8	in	in	IN
cord-001835-0s7ok4uw	4610	9	partial	partial	JJ
cord-001835-0s7ok4uw	4610	10	interfaces	interface	NNS
cord-001835-0s7ok4uw	4610	11	are	be	VBP
cord-001835-0s7ok4uw	4610	12	much	much	RB
cord-001835-0s7ok4uw	4610	13	less	less	RBR
cord-001835-0s7ok4uw	4610	14	favoured	favoured	JJ
cord-001835-0s7ok4uw	4610	15	than	than	IN
cord-001835-0s7ok4uw	4610	16	the	the	DT
cord-001835-0s7ok4uw	4610	17	ones	one	NNS
cord-001835-0s7ok4uw	4610	18	observed	observe	VBN
cord-001835-0s7ok4uw	4610	19	in	in	IN
cord-001835-0s7ok4uw	4610	20	native	native	JJ
cord-001835-0s7ok4uw	4610	21	and	and	CC
cord-001835-0s7ok4uw	4610	22	back	back	NN
cord-001835-0s7ok4uw	4610	23	-	-	HYPH
cord-001835-0s7ok4uw	4610	24	to	to	IN
cord-001835-0s7ok4uw	4610	25	-	-	HYPH
cord-001835-0s7ok4uw	4610	26	back	back	NN
cord-001835-0s7ok4uw	4610	27	interfaces	interface	NNS
cord-001835-0s7ok4uw	4610	28	.	.	.
cord-001835-0s7ok4uw	4611	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4611	2	hypothesise	hypothesise	VBP
cord-001835-0s7ok4uw	4611	3	that	that	IN
cord-001835-0s7ok4uw	4611	4	this	this	DT
cord-001835-0s7ok4uw	4611	5	phenomenon	phenomenon	NN
cord-001835-0s7ok4uw	4611	6	is	be	VBZ
cord-001835-0s7ok4uw	4611	7	related	relate	VBN
cord-001835-0s7ok4uw	4611	8	to	to	IN
cord-001835-0s7ok4uw	4611	9	the	the	DT
cord-001835-0s7ok4uw	4611	10	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	4611	11	of	of	IN
cord-001835-0s7ok4uw	4611	12	the	the	DT
cord-001835-0s7ok4uw	4611	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	4611	14	association	association	NN
cord-001835-0s7ok4uw	4611	15	process	process	NN
cord-001835-0s7ok4uw	4611	16	.	.	.
cord-001835-0s7ok4uw	4612	1	Back	Back	NNP
cord-001835-0s7ok4uw	4612	2	-	-	HYPH
cord-001835-0s7ok4uw	4612	3	to	to	IN
cord-001835-0s7ok4uw	4612	4	-	-	HYPH
cord-001835-0s7ok4uw	4612	5	back	back	NN
cord-001835-0s7ok4uw	4612	6	interfaces	interface	NNS
cord-001835-0s7ok4uw	4612	7	preserve	preserve	VBP
cord-001835-0s7ok4uw	4612	8	the	the	DT
cord-001835-0s7ok4uw	4612	9	exposure	exposure	NN
cord-001835-0s7ok4uw	4612	10	of	of	IN
cord-001835-0s7ok4uw	4612	11	the	the	DT
cord-001835-0s7ok4uw	4612	12	real	real	JJ
cord-001835-0s7ok4uw	4612	13	interacting	interact	VBG
cord-001835-0s7ok4uw	4612	14	patches	patch	NNS
cord-001835-0s7ok4uw	4612	15	(	(	-LRB-
cord-001835-0s7ok4uw	4612	16	thus	thus	RB
cord-001835-0s7ok4uw	4612	17	,	,	,
cord-001835-0s7ok4uw	4612	18	allowing	allow	VBG
cord-001835-0s7ok4uw	4612	19	the	the	DT
cord-001835-0s7ok4uw	4612	20	formation	formation	NN
cord-001835-0s7ok4uw	4612	21	of	of	IN
cord-001835-0s7ok4uw	4612	22	a	a	DT
cord-001835-0s7ok4uw	4612	23	native	native	JJ
cord-001835-0s7ok4uw	4612	24	interface	interface	NN
cord-001835-0s7ok4uw	4612	25	)	)	-RRB-
cord-001835-0s7ok4uw	4612	26	,	,	,
cord-001835-0s7ok4uw	4612	27	while	while	IN
cord-001835-0s7ok4uw	4612	28	in	in	IN
cord-001835-0s7ok4uw	4612	29	a	a	DT
cord-001835-0s7ok4uw	4612	30	partial	partial	JJ
cord-001835-0s7ok4uw	4612	31	interface	interface	NN
cord-001835-0s7ok4uw	4612	32	one	one	CD
cord-001835-0s7ok4uw	4612	33	interacting	interact	VBG
cord-001835-0s7ok4uw	4612	34	patch	patch	NN
cord-001835-0s7ok4uw	4612	35	is	be	VBZ
cord-001835-0s7ok4uw	4612	36	sequestered	sequester	VBN
cord-001835-0s7ok4uw	4612	37	and	and	CC
cord-001835-0s7ok4uw	4612	38	becomes	become	VBZ
cord-001835-0s7ok4uw	4612	39	unavailable	unavailable	JJ
cord-001835-0s7ok4uw	4612	40	to	to	TO
cord-001835-0s7ok4uw	4612	41	form	form	VB
cord-001835-0s7ok4uw	4612	42	a	a	DT
cord-001835-0s7ok4uw	4612	43	native	native	JJ
cord-001835-0s7ok4uw	4612	44	interaction	interaction	NN
cord-001835-0s7ok4uw	4612	45	.	.	.
cord-001835-0s7ok4uw	4613	1	Structural	structural	JJ
cord-001835-0s7ok4uw	4613	2	characterization	characterization	NN
cord-001835-0s7ok4uw	4613	3	of	of	IN
cord-001835-0s7ok4uw	4613	4	the	the	DT
cord-001835-0s7ok4uw	4613	5	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	4613	6	mRNA	mRNA	NNP
cord-001835-0s7ok4uw	4613	7	export	export	NNP
cord-001835-0s7ok4uw	4613	8	platform	platform	NNP
cord-001835-0s7ok4uw	4613	9	Laboratory	Laboratory	NNP
cord-001835-0s7ok4uw	4613	10	of	of	IN
cord-001835-0s7ok4uw	4613	11	Cellular	Cellular	NNP
cord-001835-0s7ok4uw	4613	12	and	and	CC
cord-001835-0s7ok4uw	4613	13	Structural	Structural	NNP
cord-001835-0s7ok4uw	4613	14	Biology	Biology	NNP
cord-001835-0s7ok4uw	4613	15	,	,	,
cord-001835-0s7ok4uw	4613	16	The	the	DT
cord-001835-0s7ok4uw	4613	17	Rockefeller	Rockefeller	NNP
cord-001835-0s7ok4uw	4613	18	University	University	NNP
cord-001835-0s7ok4uw	4613	19	.	.	.
cord-001835-0s7ok4uw	4614	1	,	,	,
cord-001835-0s7ok4uw	4614	2	2	2	CD
cord-001835-0s7ok4uw	4614	3	Laboratory	Laboratory	NNP
cord-001835-0s7ok4uw	4614	4	of	of	IN
cord-001835-0s7ok4uw	4614	5	Mass	Mass	NNP
cord-001835-0s7ok4uw	4614	6	Spectrometry	Spectrometry	NNP
cord-001835-0s7ok4uw	4614	7	and	and	CC
cord-001835-0s7ok4uw	4614	8	Gaseous	Gaseous	NNP
cord-001835-0s7ok4uw	4614	9	Ion	Ion	NNP
cord-001835-0s7ok4uw	4614	10	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	4614	11	,	,	,
cord-001835-0s7ok4uw	4614	12	The	the	DT
cord-001835-0s7ok4uw	4614	13	Rockefeller	Rockefeller	NNP
cord-001835-0s7ok4uw	4614	14	Univ	Univ	NNP
cord-001835-0s7ok4uw	4614	15	.	.	NNP
cord-001835-0s7ok4uw	4614	16	,	,	,
cord-001835-0s7ok4uw	4614	17	3	3	CD
cord-001835-0s7ok4uw	4614	18	University	University	NNP
cord-001835-0s7ok4uw	4614	19	of	of	IN
cord-001835-0s7ok4uw	4614	20	California	California	NNP
cord-001835-0s7ok4uw	4614	21	,	,	,
cord-001835-0s7ok4uw	4614	22	San	San	NNP
cord-001835-0s7ok4uw	4614	23	Francisco	Francisco	NNP
cord-001835-0s7ok4uw	4614	24	,	,	,
cord-001835-0s7ok4uw	4614	25	4	4	CD
cord-001835-0s7ok4uw	4614	26	The	the	DT
cord-001835-0s7ok4uw	4614	27	New	New	NNP
cord-001835-0s7ok4uw	4614	28	York	York	NNP
cord-001835-0s7ok4uw	4614	29	Structural	Structural	NNP
cord-001835-0s7ok4uw	4614	30	Biology	Biology	NNP
cord-001835-0s7ok4uw	4614	31	Center	Center	NNP
cord-001835-0s7ok4uw	4614	32	,	,	,
cord-001835-0s7ok4uw	4615	1	5	5	CD
cord-001835-0s7ok4uw	4615	2	Department	Department	NNP
cord-001835-0s7ok4uw	4615	3	of	of	IN
cord-001835-0s7ok4uw	4615	4	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	4615	5	,	,	,
cord-001835-0s7ok4uw	4615	6	Faculty	Faculty	NNP
cord-001835-0s7ok4uw	4615	7	of	of	IN
cord-001835-0s7ok4uw	4615	8	Medicine	Medicine	NNP
cord-001835-0s7ok4uw	4615	9	,	,	,
cord-001835-0s7ok4uw	4615	10	University	University	NNP
cord-001835-0s7ok4uw	4615	11	of	of	IN
cord-001835-0s7ok4uw	4615	12	Montreal	Montreal	NNP
cord-001835-0s7ok4uw	4615	13	mRNA	mRNA	NNP
cord-001835-0s7ok4uw	4615	14	biogenesis	biogenesis	NN
cord-001835-0s7ok4uw	4615	15	is	be	VBZ
cord-001835-0s7ok4uw	4615	16	an	an	DT
cord-001835-0s7ok4uw	4615	17	intricate	intricate	JJ
cord-001835-0s7ok4uw	4615	18	process	process	NN
cord-001835-0s7ok4uw	4615	19	that	that	WDT
cord-001835-0s7ok4uw	4615	20	begins	begin	VBZ
cord-001835-0s7ok4uw	4615	21	within	within	IN
cord-001835-0s7ok4uw	4615	22	the	the	DT
cord-001835-0s7ok4uw	4615	23	nucleus	nucleus	NN
cord-001835-0s7ok4uw	4615	24	and	and	CC
cord-001835-0s7ok4uw	4615	25	culminates	culminate	VBZ
cord-001835-0s7ok4uw	4615	26	with	with	IN
cord-001835-0s7ok4uw	4615	27	the	the	DT
cord-001835-0s7ok4uw	4615	28	remodeling	remodeling	NN
cord-001835-0s7ok4uw	4615	29	and	and	CC
cord-001835-0s7ok4uw	4615	30	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	4615	31	export	export	NN
cord-001835-0s7ok4uw	4615	32	of	of	IN
cord-001835-0s7ok4uw	4615	33	the	the	DT
cord-001835-0s7ok4uw	4615	34	mRNP	mrnp	NN
cord-001835-0s7ok4uw	4615	35	particles	particle	NNS
cord-001835-0s7ok4uw	4615	36	through	through	IN
cord-001835-0s7ok4uw	4615	37	the	the	DT
cord-001835-0s7ok4uw	4615	38	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	4615	39	pore	pore	NN
cord-001835-0s7ok4uw	4615	40	complex	complex	NN
cord-001835-0s7ok4uw	4615	41	(	(	-LRB-
cord-001835-0s7ok4uw	4615	42	NPC	NPC	NNP
cord-001835-0s7ok4uw	4615	43	)	)	-RRB-
cord-001835-0s7ok4uw	4615	44	.	.	.
cord-001835-0s7ok4uw	4616	1	Defects	defect	NNS
cord-001835-0s7ok4uw	4616	2	in	in	IN
cord-001835-0s7ok4uw	4616	3	this	this	DT
cord-001835-0s7ok4uw	4616	4	conserved	conserve	VBN
cord-001835-0s7ok4uw	4616	5	mechanism	mechanism	NN
cord-001835-0s7ok4uw	4616	6	have	have	VBP
cord-001835-0s7ok4uw	4616	7	been	be	VBN
cord-001835-0s7ok4uw	4616	8	shown	show	VBN
cord-001835-0s7ok4uw	4616	9	to	to	TO
cord-001835-0s7ok4uw	4616	10	cause	cause	VB
cord-001835-0s7ok4uw	4616	11	serious	serious	JJ
cord-001835-0s7ok4uw	4616	12	human	human	JJ
cord-001835-0s7ok4uw	4616	13	diseases	disease	NNS
cord-001835-0s7ok4uw	4616	14	.	.	.
cord-001835-0s7ok4uw	4617	1	The	the	DT
cord-001835-0s7ok4uw	4617	2	protein	protein	NN
cord-001835-0s7ok4uw	4617	3	assembly	assembly	NN
cord-001835-0s7ok4uw	4617	4	that	that	WDT
cord-001835-0s7ok4uw	4617	5	performs	perform	VBZ
cord-001835-0s7ok4uw	4617	6	the	the	DT
cord-001835-0s7ok4uw	4617	7	last	last	JJ
cord-001835-0s7ok4uw	4617	8	steps	step	NNS
cord-001835-0s7ok4uw	4617	9	in	in	IN
cord-001835-0s7ok4uw	4617	10	mRNP	mRNP	``
cord-001835-0s7ok4uw	4617	11	biogenesis	biogenesis	NN
cord-001835-0s7ok4uw	4617	12	and	and	CC
cord-001835-0s7ok4uw	4617	13	export	export	NN
cord-001835-0s7ok4uw	4617	14	is	be	VBZ
cord-001835-0s7ok4uw	4617	15	located	locate	VBN
cord-001835-0s7ok4uw	4617	16	at	at	IN
cord-001835-0s7ok4uw	4617	17	the	the	DT
cord-001835-0s7ok4uw	4617	18	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	4617	19	face	face	NN
cord-001835-0s7ok4uw	4617	20	of	of	IN
cord-001835-0s7ok4uw	4617	21	the	the	DT
cord-001835-0s7ok4uw	4617	22	NPC	NPC	NNP
cord-001835-0s7ok4uw	4617	23	and	and	CC
cord-001835-0s7ok4uw	4617	24	is	be	VBZ
cord-001835-0s7ok4uw	4617	25	formed	form	VBN
cord-001835-0s7ok4uw	4617	26	by	by	IN
cord-001835-0s7ok4uw	4617	27	14	14	CD
cord-001835-0s7ok4uw	4617	28	different	different	JJ
cord-001835-0s7ok4uw	4617	29	proteins	protein	NNS
cord-001835-0s7ok4uw	4617	30	,	,	,
cord-001835-0s7ok4uw	4617	31	organized	organize	VBN
cord-001835-0s7ok4uw	4617	32	into	into	IN
cord-001835-0s7ok4uw	4617	33	several	several	JJ
cord-001835-0s7ok4uw	4617	34	subcomplexes	subcomplexe	NNS
cord-001835-0s7ok4uw	4617	35	whose	whose	WP$
cord-001835-0s7ok4uw	4617	36	arrangement	arrangement	NN
cord-001835-0s7ok4uw	4617	37	and	and	CC
cord-001835-0s7ok4uw	4617	38	molecular	molecular	JJ
cord-001835-0s7ok4uw	4617	39	architecture	architecture	NN
cord-001835-0s7ok4uw	4617	40	are	be	VBP
cord-001835-0s7ok4uw	4617	41	poorly	poorly	RB
cord-001835-0s7ok4uw	4617	42	understood	understand	VBN
cord-001835-0s7ok4uw	4617	43	.	.	.
cord-001835-0s7ok4uw	4618	1	In	in	IN
cord-001835-0s7ok4uw	4618	2	this	this	DT
cord-001835-0s7ok4uw	4618	3	study	study	NN
cord-001835-0s7ok4uw	4618	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	4618	5	applied	apply	VBD
cord-001835-0s7ok4uw	4618	6	an	an	DT
cord-001835-0s7ok4uw	4618	7	integrative	integrative	JJ
cord-001835-0s7ok4uw	4618	8	approach	approach	NN
cord-001835-0s7ok4uw	4618	9	,	,	,
cord-001835-0s7ok4uw	4618	10	combining	combine	VBG
cord-001835-0s7ok4uw	4618	11	cross	cross	NN
cord-001835-0s7ok4uw	4618	12	-	-	JJ
cord-001835-0s7ok4uw	4618	13	linking	linking	JJ
cord-001835-0s7ok4uw	4618	14	and	and	CC
cord-001835-0s7ok4uw	4618	15	mass	mass	NN
cord-001835-0s7ok4uw	4618	16	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4618	17	(	(	-LRB-
cord-001835-0s7ok4uw	4618	18	CX	CX	NNP
cord-001835-0s7ok4uw	4618	19	-	-	HYPH
cord-001835-0s7ok4uw	4618	20	MS	MS	NNP
cord-001835-0s7ok4uw	4618	21	)	)	-RRB-
cord-001835-0s7ok4uw	4618	22	,	,	,
cord-001835-0s7ok4uw	4618	23	electron	electron	NN
cord-001835-0s7ok4uw	4618	24	microscopy	microscopy	NNS
cord-001835-0s7ok4uw	4618	25	and	and	CC
cord-001835-0s7ok4uw	4618	26	available	available	JJ
cord-001835-0s7ok4uw	4618	27	high	high	JJ
cord-001835-0s7ok4uw	4618	28	-	-	HYPH
cord-001835-0s7ok4uw	4618	29	resolution	resolution	NN
cord-001835-0s7ok4uw	4618	30	structures	structure	NNS
cord-001835-0s7ok4uw	4618	31	,	,	,
cord-001835-0s7ok4uw	4618	32	to	to	TO
cord-001835-0s7ok4uw	4618	33	describe	describe	VB
cord-001835-0s7ok4uw	4618	34	the	the	DT
cord-001835-0s7ok4uw	4618	35	molecular	molecular	JJ
cord-001835-0s7ok4uw	4618	36	architecture	architecture	NN
cord-001835-0s7ok4uw	4618	37	of	of	IN
cord-001835-0s7ok4uw	4618	38	the	the	DT
cord-001835-0s7ok4uw	4618	39	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	4618	40	NPC	NPC	NNP
cord-001835-0s7ok4uw	4618	41	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	4618	42	mRNP	mrnp	JJ
cord-001835-0s7ok4uw	4618	43	export	export	NN
cord-001835-0s7ok4uw	4618	44	machinery	machinery	NN
cord-001835-0s7ok4uw	4618	45	.	.	.
cord-001835-0s7ok4uw	4619	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4619	2	generate	generate	VBP
cord-001835-0s7ok4uw	4619	3	a	a	DT
cord-001835-0s7ok4uw	4619	4	hybrid	hybrid	NN
cord-001835-0s7ok4uw	4619	5	,	,	,
cord-001835-0s7ok4uw	4619	6	close	close	JJ
cord-001835-0s7ok4uw	4619	7	-	-	HYPH
cord-001835-0s7ok4uw	4619	8	to	to	IN
cord-001835-0s7ok4uw	4619	9	-	-	HYPH
cord-001835-0s7ok4uw	4619	10	atomic	atomic	JJ
cord-001835-0s7ok4uw	4619	11	structure	structure	NN
cord-001835-0s7ok4uw	4619	12	of	of	IN
cord-001835-0s7ok4uw	4619	13	the	the	DT
cord-001835-0s7ok4uw	4619	14	yeast	yeast	NN
cord-001835-0s7ok4uw	4619	15	native	native	JJ
cord-001835-0s7ok4uw	4619	16	Nup82	Nup82	NNP
cord-001835-0s7ok4uw	4619	17	complex	complex	NN
cord-001835-0s7ok4uw	4619	18	,	,	,
cord-001835-0s7ok4uw	4619	19	the	the	DT
cord-001835-0s7ok4uw	4619	20	core	core	NN
cord-001835-0s7ok4uw	4619	21	of	of	IN
cord-001835-0s7ok4uw	4619	22	the	the	DT
cord-001835-0s7ok4uw	4619	23	assembly	assembly	NN
cord-001835-0s7ok4uw	4619	24	.	.	.
cord-001835-0s7ok4uw	4620	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4620	2	map	map	NN
cord-001835-0s7ok4uw	4620	3	also	also	RB
cord-001835-0s7ok4uw	4620	4	reveals	reveal	VBZ
cord-001835-0s7ok4uw	4620	5	how	how	WRB
cord-001835-0s7ok4uw	4620	6	the	the	DT
cord-001835-0s7ok4uw	4620	7	Nup82	Nup82	NNP
cord-001835-0s7ok4uw	4620	8	complex	complex	NN
cord-001835-0s7ok4uw	4620	9	organizes	organize	VBZ
cord-001835-0s7ok4uw	4620	10	the	the	DT
cord-001835-0s7ok4uw	4620	11	entire	entire	JJ
cord-001835-0s7ok4uw	4620	12	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	4620	13	mRNP	mrnp	JJ
cord-001835-0s7ok4uw	4620	14	export	export	NN
cord-001835-0s7ok4uw	4620	15	machinery	machinery	NN
cord-001835-0s7ok4uw	4620	16	,	,	,
cord-001835-0s7ok4uw	4620	17	and	and	CC
cord-001835-0s7ok4uw	4620	18	how	how	WRB
cord-001835-0s7ok4uw	4620	19	this	this	DT
cord-001835-0s7ok4uw	4620	20	in	in	IN
cord-001835-0s7ok4uw	4620	21	turn	turn	NN
cord-001835-0s7ok4uw	4620	22	docks	dock	NNS
cord-001835-0s7ok4uw	4620	23	into	into	IN
cord-001835-0s7ok4uw	4620	24	the	the	DT
cord-001835-0s7ok4uw	4620	25	architectural	architectural	JJ
cord-001835-0s7ok4uw	4620	26	core	core	NN
cord-001835-0s7ok4uw	4620	27	of	of	IN
cord-001835-0s7ok4uw	4620	28	the	the	DT
cord-001835-0s7ok4uw	4620	29	NPC	NPC	NNP
cord-001835-0s7ok4uw	4620	30	.	.	.
cord-001835-0s7ok4uw	4621	1	Mapping	mapping	NN
cord-001835-0s7ok4uw	4621	2	of	of	IN
cord-001835-0s7ok4uw	4621	3	phenotypic	phenotypic	JJ
cord-001835-0s7ok4uw	4621	4	profiles	profile	NNS
cord-001835-0s7ok4uw	4621	5	into	into	IN
cord-001835-0s7ok4uw	4621	6	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4621	7	structures	structure	NNS
cord-001835-0s7ok4uw	4621	8	allows	allow	VBZ
cord-001835-0s7ok4uw	4621	9	us	-PRON-	PRP
cord-001835-0s7ok4uw	4621	10	to	to	TO
cord-001835-0s7ok4uw	4621	11	generate	generate	VB
cord-001835-0s7ok4uw	4621	12	a	a	DT
cord-001835-0s7ok4uw	4621	13	first	first	JJ
cord-001835-0s7ok4uw	4621	14	functional	functional	JJ
cord-001835-0s7ok4uw	4621	15	map	map	NN
cord-001835-0s7ok4uw	4621	16	of	of	IN
cord-001835-0s7ok4uw	4621	17	the	the	DT
cord-001835-0s7ok4uw	4621	18	ensemble	ensemble	NN
cord-001835-0s7ok4uw	4621	19	.	.	.
cord-001835-0s7ok4uw	4622	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4622	2	expect	expect	VBP
cord-001835-0s7ok4uw	4622	3	that	that	IN
cord-001835-0s7ok4uw	4622	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4622	5	map	map	NN
cord-001835-0s7ok4uw	4622	6	will	will	MD
cord-001835-0s7ok4uw	4622	7	serve	serve	VB
cord-001835-0s7ok4uw	4622	8	as	as	IN
cord-001835-0s7ok4uw	4622	9	a	a	DT
cord-001835-0s7ok4uw	4622	10	framework	framework	NN
cord-001835-0s7ok4uw	4622	11	to	to	TO
cord-001835-0s7ok4uw	4622	12	understand	understand	VB
cord-001835-0s7ok4uw	4622	13	the	the	DT
cord-001835-0s7ok4uw	4622	14	molecular	molecular	JJ
cord-001835-0s7ok4uw	4622	15	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4622	16	underlying	underlie	VBG
cord-001835-0s7ok4uw	4622	17	this	this	DT
cord-001835-0s7ok4uw	4622	18	key	key	JJ
cord-001835-0s7ok4uw	4622	19	step	step	NN
cord-001835-0s7ok4uw	4622	20	of	of	IN
cord-001835-0s7ok4uw	4622	21	mRNP	mRNP	VBG
cord-001835-0s7ok4uw	4622	22	biogenesis	biogenesis	NN
cord-001835-0s7ok4uw	4622	23	.	.	.
cord-001835-0s7ok4uw	4623	1	Study	study	NN
cord-001835-0s7ok4uw	4623	2	of	of	IN
cord-001835-0s7ok4uw	4623	3	candidate	candidate	NN
cord-001835-0s7ok4uw	4623	4	proteins	protein	NNS
cord-001835-0s7ok4uw	4623	5	to	to	TO
cord-001835-0s7ok4uw	4623	6	pore	pore	VB
cord-001835-0s7ok4uw	4623	7	associated	associate	VBN
cord-001835-0s7ok4uw	4623	8	with	with	IN
cord-001835-0s7ok4uw	4623	9	P2X7	P2X7	NNP
cord-001835-0s7ok4uw	4623	10	receptor	receptor	NN
cord-001835-0s7ok4uw	4623	11	in	in	IN
cord-001835-0s7ok4uw	4623	12	different	different	JJ
cord-001835-0s7ok4uw	4623	13	cell	cell	NN
cord-001835-0s7ok4uw	4623	14	types	type	NNS
cord-001835-0s7ok4uw	4623	15	Carla	Carla	NNP
cord-001835-0s7ok4uw	4623	16	Oliveira	Oliveira	NNP
cord-001835-0s7ok4uw	4623	17	1	1	CD
cord-001835-0s7ok4uw	4623	18	,	,	,
cord-001835-0s7ok4uw	4623	19	Anael	Anael	NNP
cord-001835-0s7ok4uw	4623	20	Alberto	Alberto	NNP
cord-001835-0s7ok4uw	4623	21	1	1	CD
cord-001835-0s7ok4uw	4623	22	,	,	,
cord-001835-0s7ok4uw	4623	23	Mônica	Mônica	NNP
cord-001835-0s7ok4uw	4623	24	Freitas	Freitas	NNP
cord-001835-0s7ok4uw	4623	25	2	2	CD
cord-001835-0s7ok4uw	4623	26	,	,	,
cord-001835-0s7ok4uw	4623	27	Luiz	Luiz	NNP
cord-001835-0s7ok4uw	4623	28	Alves	Alves	NNP
cord-001835-0s7ok4uw	4623	29	1	1	CD
cord-001835-0s7ok4uw	4623	30	1	1	CD
cord-001835-0s7ok4uw	4624	1	Laborat	Laborat	NNP
cord-001835-0s7ok4uw	4624	2	orio	orio	NNP
cord-001835-0s7ok4uw	4624	3	de	de	IN
cord-001835-0s7ok4uw	4624	4	Comunicac¸ão	Comunicac¸ão	NNP
cord-001835-0s7ok4uw	4624	5	Celular	Celular	NNP
cord-001835-0s7ok4uw	4624	6	-FIOCRUZ	-FIOCRUZ	NNP
cord-001835-0s7ok4uw	4624	7	,	,	,
cord-001835-0s7ok4uw	4624	8	2	2	CD
cord-001835-0s7ok4uw	4624	9	Centro	Centro	NNP
cord-001835-0s7ok4uw	4624	10	Nacional	Nacional	NNP
cord-001835-0s7ok4uw	4624	11	de	de	NNP
cord-001835-0s7ok4uw	4624	12	Ressonância	Ressonância	NNP
cord-001835-0s7ok4uw	4624	13	Magn	Magn	NNP
cord-001835-0s7ok4uw	4625	1	etica	etica	NNP
cord-001835-0s7ok4uw	4626	1	Nuclear	nuclear	JJ
cord-001835-0s7ok4uw	4627	1	-UFRJ	-UFRJ	.
cord-001835-0s7ok4uw	4628	1	Aim	aim	VB
cord-001835-0s7ok4uw	4628	2	:	:	:
cord-001835-0s7ok4uw	4628	3	The	the	DT
cord-001835-0s7ok4uw	4628	4	P2X7R	P2X7R	NNP
cord-001835-0s7ok4uw	4628	5	is	be	VBZ
cord-001835-0s7ok4uw	4628	6	a	a	DT
cord-001835-0s7ok4uw	4628	7	purinergic	purinergic	JJ
cord-001835-0s7ok4uw	4628	8	receptor	receptor	NN
cord-001835-0s7ok4uw	4628	9	,	,	,
cord-001835-0s7ok4uw	4628	10	which	which	WDT
cord-001835-0s7ok4uw	4628	11	differs	differ	VBZ
cord-001835-0s7ok4uw	4628	12	from	from	IN
cord-001835-0s7ok4uw	4628	13	others	other	NNS
cord-001835-0s7ok4uw	4628	14	subtypes	subtype	NNS
cord-001835-0s7ok4uw	4628	15	due	due	JJ
cord-001835-0s7ok4uw	4628	16	to	to	IN
cord-001835-0s7ok4uw	4628	17	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4628	18	structural	structural	JJ
cord-001835-0s7ok4uw	4628	19	and	and	CC
cord-001835-0s7ok4uw	4628	20	pharmacological	pharmacological	JJ
cord-001835-0s7ok4uw	4628	21	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	4628	22	.	.	.
cord-001835-0s7ok4uw	4629	1	When	when	WRB
cord-001835-0s7ok4uw	4629	2	exposed	expose	VBN
cord-001835-0s7ok4uw	4629	3	for	for	IN
cord-001835-0s7ok4uw	4629	4	extended	extended	JJ
cord-001835-0s7ok4uw	4629	5	time	time	NN
cord-001835-0s7ok4uw	4629	6	or	or	CC
cord-001835-0s7ok4uw	4629	7	to	to	IN
cord-001835-0s7ok4uw	4629	8	high	high	JJ
cord-001835-0s7ok4uw	4629	9	concentrations	concentration	NNS
cord-001835-0s7ok4uw	4629	10	of	of	IN
cord-001835-0s7ok4uw	4629	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4629	12	agonist	agonist	NN
cord-001835-0s7ok4uw	4629	13	(	(	-LRB-
cord-001835-0s7ok4uw	4629	14	ATP	ATP	NNP
cord-001835-0s7ok4uw	4629	15	)	)	-RRB-
cord-001835-0s7ok4uw	4629	16	,	,	,
cord-001835-0s7ok4uw	4629	17	promotes	promote	VBZ
cord-001835-0s7ok4uw	4629	18	an	an	DT
cord-001835-0s7ok4uw	4629	19	increase	increase	NN
cord-001835-0s7ok4uw	4629	20	in	in	IN
cord-001835-0s7ok4uw	4629	21	membrane	membrane	NN
cord-001835-0s7ok4uw	4629	22	permeability	permeability	NN
cord-001835-0s7ok4uw	4629	23	,	,	,
cord-001835-0s7ok4uw	4629	24	allowing	allow	VBG
cord-001835-0s7ok4uw	4629	25	the	the	DT
cord-001835-0s7ok4uw	4629	26	passage	passage	NN
cord-001835-0s7ok4uw	4629	27	of	of	IN
cord-001835-0s7ok4uw	4629	28	molecules	molecule	NNS
cord-001835-0s7ok4uw	4629	29	up	up	IN
cord-001835-0s7ok4uw	4629	30	to	to	IN
cord-001835-0s7ok4uw	4629	31	900Da	900da	CD
cord-001835-0s7ok4uw	4629	32	.	.	.
cord-001835-0s7ok4uw	4630	1	There	there	EX
cord-001835-0s7ok4uw	4630	2	is	be	VBZ
cord-001835-0s7ok4uw	4630	3	a	a	DT
cord-001835-0s7ok4uw	4630	4	controversy	controversy	NN
cord-001835-0s7ok4uw	4630	5	among	among	IN
cord-001835-0s7ok4uw	4630	6	several	several	JJ
cord-001835-0s7ok4uw	4630	7	authors	author	NNS
cord-001835-0s7ok4uw	4630	8	that	that	WDT
cord-001835-0s7ok4uw	4630	9	leave	leave	VBP
cord-001835-0s7ok4uw	4630	10	in	in	IN
cord-001835-0s7ok4uw	4630	11	doubt	doubt	NN
cord-001835-0s7ok4uw	4630	12	if	if	IN
cord-001835-0s7ok4uw	4630	13	this	this	DT
cord-001835-0s7ok4uw	4630	14	receptor	receptor	NN
cord-001835-0s7ok4uw	4630	15	needs	need	VBZ
cord-001835-0s7ok4uw	4630	16	a	a	DT
cord-001835-0s7ok4uw	4630	17	second	second	JJ
cord-001835-0s7ok4uw	4630	18	protein	protein	NN
cord-001835-0s7ok4uw	4630	19	for	for	IN
cord-001835-0s7ok4uw	4630	20	the	the	DT
cord-001835-0s7ok4uw	4630	21	pore	pore	NN
cord-001835-0s7ok4uw	4630	22	formation	formation	NN
cord-001835-0s7ok4uw	4630	23	and	and	CC
cord-001835-0s7ok4uw	4630	24	which	which	WDT
cord-001835-0s7ok4uw	4630	25	protein	protein	NN
cord-001835-0s7ok4uw	4630	26	could	could	MD
cord-001835-0s7ok4uw	4630	27	be	be	VB
cord-001835-0s7ok4uw	4630	28	.	.	.
cord-001835-0s7ok4uw	4631	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4631	2	select	select	VBP
cord-001835-0s7ok4uw	4631	3	five	five	CD
cord-001835-0s7ok4uw	4631	4	pore	pore	NN
cord-001835-0s7ok4uw	4631	5	-	-	HYPH
cord-001835-0s7ok4uw	4631	6	forming	form	VBG
cord-001835-0s7ok4uw	4631	7	proteins	protein	NNS
cord-001835-0s7ok4uw	4631	8	:	:	:
cord-001835-0s7ok4uw	4631	9	TRPV1	TRPV1	NNP
cord-001835-0s7ok4uw	4631	10	,	,	,
cord-001835-0s7ok4uw	4631	11	TRPA1	trpa1	XX
cord-001835-0s7ok4uw	4631	12	,	,	,
cord-001835-0s7ok4uw	4631	13	Connexins-43	Connexins-43	NNP
cord-001835-0s7ok4uw	4631	14	(	(	-LRB-
cord-001835-0s7ok4uw	4631	15	Cx-43	Cx-43	NNP
cord-001835-0s7ok4uw	4631	16	)	)	-RRB-
cord-001835-0s7ok4uw	4631	17	,	,	,
cord-001835-0s7ok4uw	4631	18	Pannexin-1	Pannexin-1	NNP
cord-001835-0s7ok4uw	4631	19	(	(	-LRB-
cord-001835-0s7ok4uw	4631	20	Panx-1	Panx-1	NNP
cord-001835-0s7ok4uw	4631	21	)	)	-RRB-
cord-001835-0s7ok4uw	4631	22	and	and	CC
cord-001835-0s7ok4uw	4631	23	VDAC	VDAC	NNP
cord-001835-0s7ok4uw	4631	24	.	.	.
cord-001835-0s7ok4uw	4632	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4632	2	believe	believe	VBP
cord-001835-0s7ok4uw	4632	3	that	that	IN
cord-001835-0s7ok4uw	4632	4	different	different	JJ
cord-001835-0s7ok4uw	4632	5	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4632	6	and	and	CC
cord-001835-0s7ok4uw	4632	7	proteins	protein	NNS
cord-001835-0s7ok4uw	4632	8	could	could	MD
cord-001835-0s7ok4uw	4632	9	be	be	VB
cord-001835-0s7ok4uw	4632	10	associated	associate	VBN
cord-001835-0s7ok4uw	4632	11	with	with	IN
cord-001835-0s7ok4uw	4632	12	P2X7R	P2X7R	NNP
cord-001835-0s7ok4uw	4632	13	,	,	,
cord-001835-0s7ok4uw	4632	14	depending	depend	VBG
cord-001835-0s7ok4uw	4632	15	on	on	IN
cord-001835-0s7ok4uw	4632	16	the	the	DT
cord-001835-0s7ok4uw	4632	17	cell	cell	NN
cord-001835-0s7ok4uw	4632	18	type	type	NN
cord-001835-0s7ok4uw	4632	19	and	and	CC
cord-001835-0s7ok4uw	4632	20	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4632	21	microenvironment	microenvironment	NN
cord-001835-0s7ok4uw	4632	22	stimuli	stimulus	NNS
cord-001835-0s7ok4uw	4632	23	.	.	.
cord-001835-0s7ok4uw	4633	1	In	in	IN
cord-001835-0s7ok4uw	4633	2	this	this	DT
cord-001835-0s7ok4uw	4633	3	context	context	NN
cord-001835-0s7ok4uw	4633	4	,	,	,
cord-001835-0s7ok4uw	4633	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4633	6	main	main	JJ
cord-001835-0s7ok4uw	4633	7	goal	goal	NN
cord-001835-0s7ok4uw	4633	8	is	be	VBZ
cord-001835-0s7ok4uw	4633	9	identify	identify	VB
cord-001835-0s7ok4uw	4633	10	possible	possible	JJ
cord-001835-0s7ok4uw	4633	11	proteins	protein	NNS
cord-001835-0s7ok4uw	4633	12	that	that	WDT
cord-001835-0s7ok4uw	4633	13	could	could	MD
cord-001835-0s7ok4uw	4633	14	be	be	VB
cord-001835-0s7ok4uw	4633	15	associated	associate	VBN
cord-001835-0s7ok4uw	4633	16	with	with	IN
cord-001835-0s7ok4uw	4633	17	the	the	DT
cord-001835-0s7ok4uw	4633	18	P2X7R	P2X7R	NNP
cord-001835-0s7ok4uw	4633	19	pore	pore	NN
cord-001835-0s7ok4uw	4633	20	in	in	IN
cord-001835-0s7ok4uw	4633	21	different	different	JJ
cord-001835-0s7ok4uw	4633	22	cells	cell	NNS
cord-001835-0s7ok4uw	4633	23	and	and	CC
cord-001835-0s7ok4uw	4633	24	species	specie	NNS
cord-001835-0s7ok4uw	4633	25	.	.	.
cord-001835-0s7ok4uw	4634	1	Methods	method	NNS
cord-001835-0s7ok4uw	4634	2	and	and	CC
cord-001835-0s7ok4uw	4634	3	Results	result	NNS
cord-001835-0s7ok4uw	4635	1	:	:	:
cord-001835-0s7ok4uw	4635	2	We	-PRON-	PRP
cord-001835-0s7ok4uw	4635	3	started	start	VBD
cord-001835-0s7ok4uw	4635	4	with	with	IN
cord-001835-0s7ok4uw	4635	5	RT	RT	NNP
cord-001835-0s7ok4uw	4635	6	-	-	HYPH
cord-001835-0s7ok4uw	4635	7	PCR	PCR	NNP
cord-001835-0s7ok4uw	4635	8	technique	technique	NN
cord-001835-0s7ok4uw	4635	9	of	of	IN
cord-001835-0s7ok4uw	4635	10	cell	cell	NN
cord-001835-0s7ok4uw	4635	11	lines	line	NNS
cord-001835-0s7ok4uw	4635	12	:	:	:
cord-001835-0s7ok4uw	4635	13	J774.G8	J774.G8	NNP
cord-001835-0s7ok4uw	4635	14	,	,	,
cord-001835-0s7ok4uw	4635	15	N2A	n2a	CD
cord-001835-0s7ok4uw	4635	16	,	,	,
cord-001835-0s7ok4uw	4635	17	U373	u373	CD
cord-001835-0s7ok4uw	4635	18	,	,	,
cord-001835-0s7ok4uw	4635	19	U937	u937	CD
cord-001835-0s7ok4uw	4635	20	,	,	,
cord-001835-0s7ok4uw	4635	21	HEK-293	HEK-293	NNP
cord-001835-0s7ok4uw	4635	22	and	and	CC
cord-001835-0s7ok4uw	4635	23	primary	primary	JJ
cord-001835-0s7ok4uw	4635	24	cells	cell	NNS
cord-001835-0s7ok4uw	4635	25	from	from	IN
cord-001835-0s7ok4uw	4635	26	Wistar	Wistar	NNP
cord-001835-0s7ok4uw	4635	27	mouse	mouse	NN
cord-001835-0s7ok4uw	4635	28	and	and	CC
cord-001835-0s7ok4uw	4635	29	Swiss	swiss	JJ
cord-001835-0s7ok4uw	4635	30	mice	mouse	NNS
cord-001835-0s7ok4uw	4635	31	.	.	.
cord-001835-0s7ok4uw	4636	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4636	2	used	use	VBD
cord-001835-0s7ok4uw	4636	3	different	different	JJ
cord-001835-0s7ok4uw	4636	4	primers	primer	NNS
cord-001835-0s7ok4uw	4636	5	and	and	CC
cord-001835-0s7ok4uw	4636	6	PCR	PCR	NNP
cord-001835-0s7ok4uw	4636	7	cycle	cycle	NN
cord-001835-0s7ok4uw	4636	8	for	for	IN
cord-001835-0s7ok4uw	4636	9	each	each	DT
cord-001835-0s7ok4uw	4636	10	target	target	NN
cord-001835-0s7ok4uw	4636	11	at	at	IN
cord-001835-0s7ok4uw	4636	12	different	different	JJ
cord-001835-0s7ok4uw	4636	13	species	specie	NNS
cord-001835-0s7ok4uw	4636	14	.	.	.
cord-001835-0s7ok4uw	4637	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4637	2	observed	observe	VBD
cord-001835-0s7ok4uw	4637	3	that	that	IN
cord-001835-0s7ok4uw	4637	4	the	the	DT
cord-001835-0s7ok4uw	4637	5	P2X7	P2X7	NNPS
cord-001835-0s7ok4uw	4637	6	,	,	,
cord-001835-0s7ok4uw	4637	7	Panx-1	Panx-1	NNP
cord-001835-0s7ok4uw	4637	8	and	and	CC
cord-001835-0s7ok4uw	4637	9	Cx-43	Cx-43	NNP
cord-001835-0s7ok4uw	4637	10	are	be	VBP
cord-001835-0s7ok4uw	4637	11	the	the	DT
cord-001835-0s7ok4uw	4637	12	most	most	RBS
cord-001835-0s7ok4uw	4637	13	abundant	abundant	JJ
cord-001835-0s7ok4uw	4637	14	and	and	CC
cord-001835-0s7ok4uw	4637	15	are	be	VBP
cord-001835-0s7ok4uw	4637	16	present	present	JJ
cord-001835-0s7ok4uw	4637	17	in	in	IN
cord-001835-0s7ok4uw	4637	18	all	all	DT
cord-001835-0s7ok4uw	4637	19	cell	cell	NN
cord-001835-0s7ok4uw	4637	20	types	type	NNS
cord-001835-0s7ok4uw	4637	21	except	except	IN
cord-001835-0s7ok4uw	4637	22	the	the	DT
cord-001835-0s7ok4uw	4637	23	absence	absence	NN
cord-001835-0s7ok4uw	4637	24	of	of	IN
cord-001835-0s7ok4uw	4637	25	P2X7	P2X7	NNP
cord-001835-0s7ok4uw	4637	26	in	in	IN
cord-001835-0s7ok4uw	4637	27	U373	u373	JJ
cord-001835-0s7ok4uw	4637	28	cells	cell	NNS
cord-001835-0s7ok4uw	4637	29	and	and	CC
cord-001835-0s7ok4uw	4637	30	Panx-1	Panx-1	NNP
cord-001835-0s7ok4uw	4637	31	in	in	IN
cord-001835-0s7ok4uw	4637	32	mice	mouse	NNS
cord-001835-0s7ok4uw	4637	33	macrophages	macrophage	NNS
cord-001835-0s7ok4uw	4637	34	and	and	CC
cord-001835-0s7ok4uw	4637	35	U373	u373	CD
cord-001835-0s7ok4uw	4637	36	cells	cell	NNS
cord-001835-0s7ok4uw	4637	37	(	(	-LRB-
cord-001835-0s7ok4uw	4637	38	n>3	n>3	NNP
cord-001835-0s7ok4uw	4637	39	)	)	-RRB-
cord-001835-0s7ok4uw	4637	40	.	.	.
cord-001835-0s7ok4uw	4638	1	However	however	RB
cord-001835-0s7ok4uw	4638	2	,	,	,
cord-001835-0s7ok4uw	4638	3	TRPV1	TRPV1	NNP
cord-001835-0s7ok4uw	4638	4	was	be	VBD
cord-001835-0s7ok4uw	4638	5	seen	see	VBN
cord-001835-0s7ok4uw	4638	6	at	at	IN
cord-001835-0s7ok4uw	4638	7	N2A	n2a	CD
cord-001835-0s7ok4uw	4638	8	and	and	CC
cord-001835-0s7ok4uw	4638	9	U937	u937	CD
cord-001835-0s7ok4uw	4638	10	cells	cell	NNS
cord-001835-0s7ok4uw	4638	11	and	and	CC
cord-001835-0s7ok4uw	4639	1	TRPA1	trpa1	NN
cord-001835-0s7ok4uw	4639	2	in	in	IN
cord-001835-0s7ok4uw	4639	3	and	and	CC
cord-001835-0s7ok4uw	4639	4	primary	primary	JJ
cord-001835-0s7ok4uw	4639	5	cells	cell	NNS
cord-001835-0s7ok4uw	4639	6	from	from	IN
cord-001835-0s7ok4uw	4639	7	mouse	mouse	NN
cord-001835-0s7ok4uw	4639	8	and	and	CC
cord-001835-0s7ok4uw	4639	9	mice	mouse	NNS
cord-001835-0s7ok4uw	4639	10	and	and	CC
cord-001835-0s7ok4uw	4639	11	in	in	IN
cord-001835-0s7ok4uw	4639	12	J774.G8	j774.g8	NN
cord-001835-0s7ok4uw	4639	13	cells	cell	NNS
cord-001835-0s7ok4uw	4639	14	(	(	-LRB-
cord-001835-0s7ok4uw	4639	15	n>3	n>3	NNP
cord-001835-0s7ok4uw	4639	16	)	)	-RRB-
cord-001835-0s7ok4uw	4639	17	.	.	.
cord-001835-0s7ok4uw	4640	1	Regarding	regard	VBG
cord-001835-0s7ok4uw	4640	2	to	to	IN
cord-001835-0s7ok4uw	4640	3	the	the	DT
cord-001835-0s7ok4uw	4640	4	VDAC	VDAC	NNP
cord-001835-0s7ok4uw	4640	5	,	,	,
cord-001835-0s7ok4uw	4640	6	it	-PRON-	PRP
cord-001835-0s7ok4uw	4640	7	is	be	VBZ
cord-001835-0s7ok4uw	4640	8	present	present	JJ
cord-001835-0s7ok4uw	4640	9	in	in	IN
cord-001835-0s7ok4uw	4640	10	mouse	mouse	NN
cord-001835-0s7ok4uw	4640	11	macrophages	macrophage	NNS
cord-001835-0s7ok4uw	4640	12	,	,	,
cord-001835-0s7ok4uw	4640	13	J774.G8	j774.g8	NN
cord-001835-0s7ok4uw	4640	14	and	and	CC
cord-001835-0s7ok4uw	4640	15	HEK-293	HEK-293	NNP
cord-001835-0s7ok4uw	4640	16	cells	cell	NNS
cord-001835-0s7ok4uw	4640	17	(	(	-LRB-
cord-001835-0s7ok4uw	4640	18	n>3	n>3	NNP
cord-001835-0s7ok4uw	4640	19	)	)	-RRB-
cord-001835-0s7ok4uw	4640	20	.	.	.
cord-001835-0s7ok4uw	4641	1	The	the	DT
cord-001835-0s7ok4uw	4641	2	further	further	JJ
cord-001835-0s7ok4uw	4641	3	steps	step	NNS
cord-001835-0s7ok4uw	4641	4	,	,	,
cord-001835-0s7ok4uw	4641	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4641	6	verified	verify	VBD
cord-001835-0s7ok4uw	4641	7	if	if	IN
cord-001835-0s7ok4uw	4641	8	those	those	DT
cord-001835-0s7ok4uw	4641	9	proteins	protein	NNS
cord-001835-0s7ok4uw	4641	10	could	could	MD
cord-001835-0s7ok4uw	4641	11	be	be	VB
cord-001835-0s7ok4uw	4641	12	physically	physically	RB
cord-001835-0s7ok4uw	4641	13	associated	associate	VBN
cord-001835-0s7ok4uw	4641	14	with	with	IN
cord-001835-0s7ok4uw	4641	15	the	the	DT
cord-001835-0s7ok4uw	4641	16	P2X7R.	p2x7r.	NN
cord-001835-0s7ok4uw	4642	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4642	2	coimmunoprecipitated	coimmunoprecipitate	VBD
cord-001835-0s7ok4uw	4642	3	the	the	DT
cord-001835-0s7ok4uw	4642	4	P2X7R	P2X7R	NNP
cord-001835-0s7ok4uw	4642	5	of	of	IN
cord-001835-0s7ok4uw	4642	6	J774.G8	J774.G8	NNP
cord-001835-0s7ok4uw	4642	7	(	(	-LRB-
cord-001835-0s7ok4uw	4642	8	with	with	IN
cord-001835-0s7ok4uw	4642	9	or	or	CC
cord-001835-0s7ok4uw	4642	10	without	without	IN
cord-001835-0s7ok4uw	4642	11	ATP	ATP	NNP
cord-001835-0s7ok4uw	4642	12	)	)	-RRB-
cord-001835-0s7ok4uw	4642	13	,	,	,
cord-001835-0s7ok4uw	4642	14	mice	mice	NN
cord-001835-0s7ok4uw	4642	15	macrophages	macrophage	NNS
cord-001835-0s7ok4uw	4642	16	,	,	,
cord-001835-0s7ok4uw	4642	17	HEK-293	HEK-293	NNP
cord-001835-0s7ok4uw	4642	18	and	and	CC
cord-001835-0s7ok4uw	4642	19	U937	U937	NNP
cord-001835-0s7ok4uw	4642	20	cells	cell	NNS
cord-001835-0s7ok4uw	4642	21	.	.	.
cord-001835-0s7ok4uw	4643	1	The	the	DT
cord-001835-0s7ok4uw	4643	2	samples	sample	NNS
cord-001835-0s7ok4uw	4643	3	were	be	VBD
cord-001835-0s7ok4uw	4643	4	applied	apply	VBN
cord-001835-0s7ok4uw	4643	5	in	in	IN
cord-001835-0s7ok4uw	4643	6	two	two	CD
cord-001835-0s7ok4uw	4643	7	separated	separate	VBD
cord-001835-0s7ok4uw	4643	8	12.5	12.5	CD
cord-001835-0s7ok4uw	4643	9	%	%	NN
cord-001835-0s7ok4uw	4643	10	bis	bis	NN
cord-001835-0s7ok4uw	4643	11	/	/	SYM
cord-001835-0s7ok4uw	4643	12	acrylamide	acrylamide	NN
cord-001835-0s7ok4uw	4643	13	gels	gel	NNS
cord-001835-0s7ok4uw	4643	14	:	:	:
cord-001835-0s7ok4uw	4643	15	one	one	CD
cord-001835-0s7ok4uw	4643	16	destined	destine	VBN
cord-001835-0s7ok4uw	4643	17	to	to	IN
cord-001835-0s7ok4uw	4643	18	Mass	Mass	NNP
cord-001835-0s7ok4uw	4643	19	Spectrometry	Spectrometry	NNP
cord-001835-0s7ok4uw	4643	20	(	(	-LRB-
cord-001835-0s7ok4uw	4643	21	MS	MS	NNP
cord-001835-0s7ok4uw	4643	22	)	)	-RRB-
cord-001835-0s7ok4uw	4643	23	and	and	CC
cord-001835-0s7ok4uw	4643	24	the	the	DT
cord-001835-0s7ok4uw	4643	25	other	other	JJ
cord-001835-0s7ok4uw	4643	26	to	to	IN
cord-001835-0s7ok4uw	4643	27	Western	western	JJ
cord-001835-0s7ok4uw	4643	28	Blot	blot	NN
cord-001835-0s7ok4uw	4643	29	.	.	.
cord-001835-0s7ok4uw	4644	1	At	at	IN
cord-001835-0s7ok4uw	4644	2	this	this	DT
cord-001835-0s7ok4uw	4644	3	point	point	NN
cord-001835-0s7ok4uw	4644	4	,	,	,
cord-001835-0s7ok4uw	4644	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4644	6	confirmed	confirm	VBD
cord-001835-0s7ok4uw	4644	7	the	the	DT
cord-001835-0s7ok4uw	4644	8	presence	presence	NN
cord-001835-0s7ok4uw	4644	9	of	of	IN
cord-001835-0s7ok4uw	4644	10	P2X7R	P2X7R	NNP
cord-001835-0s7ok4uw	4644	11	,	,	,
cord-001835-0s7ok4uw	4644	12	and	and	CC
cord-001835-0s7ok4uw	4644	13	observed	observe	VBD
cord-001835-0s7ok4uw	4644	14	several	several	JJ
cord-001835-0s7ok4uw	4644	15	others	other	NNS
cord-001835-0s7ok4uw	4644	16	proteins	protein	NNS
cord-001835-0s7ok4uw	4644	17	associated	associate	VBN
cord-001835-0s7ok4uw	4644	18	to	to	IN
cord-001835-0s7ok4uw	4644	19	P2X7R	P2X7R	NNP
cord-001835-0s7ok4uw	4644	20	at	at	IN
cord-001835-0s7ok4uw	4644	21	different	different	JJ
cord-001835-0s7ok4uw	4644	22	cell	cell	NN
cord-001835-0s7ok4uw	4644	23	conditions	condition	NNS
cord-001835-0s7ok4uw	4644	24	,	,	,
cord-001835-0s7ok4uw	4644	25	mainly	mainly	RB
cord-001835-0s7ok4uw	4644	26	when	when	WRB
cord-001835-0s7ok4uw	4644	27	we	-PRON-	PRP
cord-001835-0s7ok4uw	4644	28	exposed	expose	VBD
cord-001835-0s7ok4uw	4644	29	,	,	,
cord-001835-0s7ok4uw	4644	30	J774.G8	j774.g8	NN
cord-001835-0s7ok4uw	4644	31	cell	cell	NN
cord-001835-0s7ok4uw	4644	32	,	,	,
cord-001835-0s7ok4uw	4644	33	to	to	IN
cord-001835-0s7ok4uw	4644	34	5	5	CD
cord-001835-0s7ok4uw	4644	35	mM	mm	CD
cord-001835-0s7ok4uw	4644	36	ATP	ATP	NNP
cord-001835-0s7ok4uw	4644	37	(	(	-LRB-
cord-001835-0s7ok4uw	4644	38	n53	n53	NN
cord-001835-0s7ok4uw	4644	39	)	)	-RRB-
cord-001835-0s7ok4uw	4644	40	.	.	.
cord-001835-0s7ok4uw	4645	1	At	at	IN
cord-001835-0s7ok4uw	4645	2	this	this	DT
cord-001835-0s7ok4uw	4645	3	condition	condition	NN
cord-001835-0s7ok4uw	4645	4	,	,	,
cord-001835-0s7ok4uw	4645	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4645	6	found	find	VBD
cord-001835-0s7ok4uw	4645	7	by	by	IN
cord-001835-0s7ok4uw	4645	8	MS	MS	NNP
cord-001835-0s7ok4uw	4645	9	,	,	,
cord-001835-0s7ok4uw	4645	10	Hsp70	Hsp70	NNP
cord-001835-0s7ok4uw	4645	11	,	,	,
cord-001835-0s7ok4uw	4645	12	75	75	CD
cord-001835-0s7ok4uw	4645	13	,	,	,
cord-001835-0s7ok4uw	4645	14	and	and	CC
cord-001835-0s7ok4uw	4645	15	90	90	CD
cord-001835-0s7ok4uw	4645	16	;	;	:
cord-001835-0s7ok4uw	4645	17	alpha	alpha	NN
cord-001835-0s7ok4uw	4645	18	and	and	CC
cord-001835-0s7ok4uw	4645	19	b	b	LS
cord-001835-0s7ok4uw	4645	20	tubulin	tubulin	NN
cord-001835-0s7ok4uw	4645	21	;	;	:
cord-001835-0s7ok4uw	4645	22	myosin	myosin	NNS
cord-001835-0s7ok4uw	4645	23	Va	Va	NNP
cord-001835-0s7ok4uw	4645	24	;	;	:
cord-001835-0s7ok4uw	4645	25	alpha	alpha	NN
cord-001835-0s7ok4uw	4645	26	,	,	,
cord-001835-0s7ok4uw	4645	27	b	b	NN
cord-001835-0s7ok4uw	4645	28	and	and	CC
cord-001835-0s7ok4uw	4645	29	g	g	NNP
cord-001835-0s7ok4uw	4645	30	actin	actin	NN
cord-001835-0s7ok4uw	4645	31	;	;	:
cord-001835-0s7ok4uw	4645	32	malate	malate	NN
cord-001835-0s7ok4uw	4645	33	and	and	CC
cord-001835-0s7ok4uw	4645	34	lactate	lactate	NN
cord-001835-0s7ok4uw	4645	35	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	4645	36	(	(	-LRB-
cord-001835-0s7ok4uw	4645	37	n51	n51	NNP
cord-001835-0s7ok4uw	4645	38	)	)	-RRB-
cord-001835-0s7ok4uw	4645	39	.	.	.
cord-001835-0s7ok4uw	4646	1	Although	although	IN
cord-001835-0s7ok4uw	4646	2	U977	U977	NNS
cord-001835-0s7ok4uw	4646	3	and	and	CC
cord-001835-0s7ok4uw	4646	4	HEK-293	HEK-293	NNP
cord-001835-0s7ok4uw	4646	5	had	have	VBD
cord-001835-0s7ok4uw	4646	6	not	not	RB
cord-001835-0s7ok4uw	4646	7	received	receive	VBN
cord-001835-0s7ok4uw	4646	8	ATP	ATP	NNP
cord-001835-0s7ok4uw	4646	9	treatment	treatment	NN
cord-001835-0s7ok4uw	4646	10	,	,	,
cord-001835-0s7ok4uw	4646	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	4646	12	found	find	VBD
cord-001835-0s7ok4uw	4646	13	several	several	JJ
cord-001835-0s7ok4uw	4646	14	proteins	protein	NNS
cord-001835-0s7ok4uw	4646	15	associated	associate	VBN
cord-001835-0s7ok4uw	4646	16	to	to	IN
cord-001835-0s7ok4uw	4646	17	P2X7	P2X7	NNP
cord-001835-0s7ok4uw	4646	18	.	.	.
cord-001835-0s7ok4uw	4647	1	The	the	DT
cord-001835-0s7ok4uw	4647	2	next	next	JJ
cord-001835-0s7ok4uw	4647	3	step	step	NN
cord-001835-0s7ok4uw	4647	4	was	be	VBD
cord-001835-0s7ok4uw	4647	5	to	to	IN
cord-001835-0s7ok4uw	4647	6	immunoprecipitated	immunoprecipitate	VBN
cord-001835-0s7ok4uw	4647	7	those	those	DT
cord-001835-0s7ok4uw	4647	8	proteins	protein	NNS
cord-001835-0s7ok4uw	4647	9	in	in	IN
cord-001835-0s7ok4uw	4647	10	J774.G8	j774.g8	NN
cord-001835-0s7ok4uw	4648	1	(	(	-LRB-
cord-001835-0s7ok4uw	4648	2	treated	treat	VBN
cord-001835-0s7ok4uw	4648	3	or	or	CC
cord-001835-0s7ok4uw	4648	4	not	not	RB
cord-001835-0s7ok4uw	4648	5	with	with	IN
cord-001835-0s7ok4uw	4648	6	ATP	ATP	NNP
cord-001835-0s7ok4uw	4648	7	)	)	-RRB-
cord-001835-0s7ok4uw	4648	8	and	and	CC
cord-001835-0s7ok4uw	4648	9	use	use	VB
cord-001835-0s7ok4uw	4648	10	it	-PRON-	PRP
cord-001835-0s7ok4uw	4648	11	to	to	TO
cord-001835-0s7ok4uw	4648	12	verify	verify	VB
cord-001835-0s7ok4uw	4648	13	if	if	IN
cord-001835-0s7ok4uw	4648	14	P2X7	P2X7	NNP
cord-001835-0s7ok4uw	4648	15	are	be	VBP
cord-001835-0s7ok4uw	4648	16	physically	physically	RB
cord-001835-0s7ok4uw	4648	17	associated	associate	VBN
cord-001835-0s7ok4uw	4648	18	to	to	IN
cord-001835-0s7ok4uw	4648	19	them	-PRON-	PRP
cord-001835-0s7ok4uw	4648	20	.	.	.
cord-001835-0s7ok4uw	4649	1	As	as	IN
cord-001835-0s7ok4uw	4649	2	result	result	NN
cord-001835-0s7ok4uw	4649	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4649	4	saw	see	VBD
cord-001835-0s7ok4uw	4649	5	the	the	DT
cord-001835-0s7ok4uw	4649	6	P2X7	P2X7	NNP
cord-001835-0s7ok4uw	4649	7	associated	associate	VBN
cord-001835-0s7ok4uw	4649	8	to	to	IN
cord-001835-0s7ok4uw	4649	9	Panx-1	Panx-1	NNP
cord-001835-0s7ok4uw	4649	10	in	in	IN
cord-001835-0s7ok4uw	4649	11	J774.G8	j774.g8	NN
cord-001835-0s7ok4uw	4649	12	cells	cell	NNS
cord-001835-0s7ok4uw	4649	13	.	.	.
cord-001835-0s7ok4uw	4650	1	Conclusion	conclusion	NN
cord-001835-0s7ok4uw	4650	2	:	:	:
cord-001835-0s7ok4uw	4651	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4651	2	conclude	conclude	VBP
cord-001835-0s7ok4uw	4651	3	that	that	IN
cord-001835-0s7ok4uw	4651	4	the	the	DT
cord-001835-0s7ok4uw	4651	5	P2X7R	P2X7R	NNP
cord-001835-0s7ok4uw	4651	6	activated	activate	VBN
cord-001835-0s7ok4uw	4651	7	by	by	IN
cord-001835-0s7ok4uw	4651	8	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	4651	9	ATP	ATP	NNP
cord-001835-0s7ok4uw	4651	10	triggers	trigger	VBZ
cord-001835-0s7ok4uw	4651	11	the	the	DT
cord-001835-0s7ok4uw	4651	12	recruitment	recruitment	NN
cord-001835-0s7ok4uw	4651	13	of	of	IN
cord-001835-0s7ok4uw	4651	14	variety	variety	NN
cord-001835-0s7ok4uw	4651	15	different	different	JJ
cord-001835-0s7ok4uw	4651	16	proteins	protein	NNS
cord-001835-0s7ok4uw	4651	17	.	.	.
cord-001835-0s7ok4uw	4652	1	At	at	IN
cord-001835-0s7ok4uw	4652	2	this	this	DT
cord-001835-0s7ok4uw	4652	3	condition	condition	NN
cord-001835-0s7ok4uw	4652	4	,	,	,
cord-001835-0s7ok4uw	4652	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4652	6	can	can	MD
cord-001835-0s7ok4uw	4652	7	suggest	suggest	VB
cord-001835-0s7ok4uw	4652	8	that	that	IN
cord-001835-0s7ok4uw	4652	9	maybe	maybe	RB
cord-001835-0s7ok4uw	4652	10	there	there	EX
cord-001835-0s7ok4uw	4652	11	is	be	VBZ
cord-001835-0s7ok4uw	4652	12	a	a	DT
cord-001835-0s7ok4uw	4652	13	conformational	conformational	JJ
cord-001835-0s7ok4uw	4652	14	change	change	NN
cord-001835-0s7ok4uw	4652	15	,	,	,
cord-001835-0s7ok4uw	4652	16	regardless	regardless	RB
cord-001835-0s7ok4uw	4652	17	of	of	IN
cord-001835-0s7ok4uw	4652	18	the	the	DT
cord-001835-0s7ok4uw	4652	19	numerous	numerous	JJ
cord-001835-0s7ok4uw	4652	20	recruitment	recruitment	JJ
cord-001835-0s7ok4uw	4652	21	structural	structural	JJ
cord-001835-0s7ok4uw	4652	22	proteins	protein	NNS
cord-001835-0s7ok4uw	4652	23	.	.	.
cord-001835-0s7ok4uw	4653	1	In	in	IN
cord-001835-0s7ok4uw	4653	2	addition	addition	NN
cord-001835-0s7ok4uw	4653	3	,	,	,
cord-001835-0s7ok4uw	4653	4	apparently	apparently	RB
cord-001835-0s7ok4uw	4653	5	,	,	,
cord-001835-0s7ok4uw	4653	6	the	the	DT
cord-001835-0s7ok4uw	4653	7	pore	pore	NN
cord-001835-0s7ok4uw	4653	8	-	-	HYPH
cord-001835-0s7ok4uw	4653	9	forming	form	VBG
cord-001835-0s7ok4uw	4653	10	protein	protein	NN
cord-001835-0s7ok4uw	4653	11	Pannexin-1	Pannexin-1	NNPS
cord-001835-0s7ok4uw	4653	12	is	be	VBZ
cord-001835-0s7ok4uw	4653	13	associated	associate	VBN
cord-001835-0s7ok4uw	4653	14	with	with	IN
cord-001835-0s7ok4uw	4653	15	P2X7R	P2X7R	NNP
cord-001835-0s7ok4uw	4653	16	,	,	,
cord-001835-0s7ok4uw	4653	17	and	and	CC
cord-001835-0s7ok4uw	4653	18	the	the	DT
cord-001835-0s7ok4uw	4653	19	others	other	NNS
cord-001835-0s7ok4uw	4653	20	pore	pore	NN
cord-001835-0s7ok4uw	4653	21	forming	form	VBG
cord-001835-0s7ok4uw	4653	22	proteins	protein	NNS
cord-001835-0s7ok4uw	4653	23	(	(	-LRB-
cord-001835-0s7ok4uw	4653	24	VDAC	VDAC	NNP
cord-001835-0s7ok4uw	4653	25	,	,	,
cord-001835-0s7ok4uw	4653	26	Cx-43	Cx-43	NNP
cord-001835-0s7ok4uw	4653	27	,	,	,
cord-001835-0s7ok4uw	4653	28	TRPV1	TRPV1	NNP
cord-001835-0s7ok4uw	4653	29	,	,	,
cord-001835-0s7ok4uw	4653	30	TRPA1	trpa1	NN
cord-001835-0s7ok4uw	4653	31	)	)	-RRB-
cord-001835-0s7ok4uw	4653	32	seems	seem	VBZ
cord-001835-0s7ok4uw	4653	33	not	not	RB
cord-001835-0s7ok4uw	4653	34	be	be	VB
cord-001835-0s7ok4uw	4653	35	linked	link	VBN
cord-001835-0s7ok4uw	4653	36	to	to	IN
cord-001835-0s7ok4uw	4653	37	P2X7R	P2X7R	NNP
cord-001835-0s7ok4uw	4653	38	at	at	IN
cord-001835-0s7ok4uw	4653	39	J774	J774	NNS
cord-001835-0s7ok4uw	4653	40	.	.	.
cord-001835-0s7ok4uw	4653	41	 	 	_SP
cord-001835-0s7ok4uw	4654	1	Recently	recently	RB
cord-001835-0s7ok4uw	4654	2	,	,	,
cord-001835-0s7ok4uw	4654	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4654	4	developed	develop	VBD
cord-001835-0s7ok4uw	4654	5	a	a	DT
cord-001835-0s7ok4uw	4654	6	series	series	NN
cord-001835-0s7ok4uw	4654	7	of	of	IN
cord-001835-0s7ok4uw	4654	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	4654	9	modeling	modeling	NN
cord-001835-0s7ok4uw	4654	10	tools	tool	NNS
cord-001835-0s7ok4uw	4654	11	for	for	IN
cord-001835-0s7ok4uw	4654	12	structure	structure	NN
cord-001835-0s7ok4uw	4654	13	-	-	HYPH
cord-001835-0s7ok4uw	4654	14	based	base	VBN
cord-001835-0s7ok4uw	4654	15	studies	study	NNS
cord-001835-0s7ok4uw	4654	16	of	of	IN
cord-001835-0s7ok4uw	4654	17	protein	protein	NN
cord-001835-0s7ok4uw	4654	18	functions	function	NNS
cord-001835-0s7ok4uw	4654	19	and	and	CC
cord-001835-0s7ok4uw	4654	20	interactions	interaction	NNS
cord-001835-0s7ok4uw	4654	21	.	.	.
cord-001835-0s7ok4uw	4655	1	These	these	DT
cord-001835-0s7ok4uw	4655	2	tools	tool	NNS
cord-001835-0s7ok4uw	4655	3	are	be	VBP
cord-001835-0s7ok4uw	4655	4	publicly	publicly	RB
cord-001835-0s7ok4uw	4655	5	available	available	JJ
cord-001835-0s7ok4uw	4655	6	as	as	IN
cord-001835-0s7ok4uw	4655	7	web	web	NN
cord-001835-0s7ok4uw	4655	8	servers	server	NNS
cord-001835-0s7ok4uw	4655	9	that	that	WDT
cord-001835-0s7ok4uw	4655	10	are	be	VBP
cord-001835-0s7ok4uw	4655	11	easily	easily	RB
cord-001835-0s7ok4uw	4655	12	operated	operate	VBN
cord-001835-0s7ok4uw	4655	13	even	even	RB
cord-001835-0s7ok4uw	4655	14	by	by	IN
cord-001835-0s7ok4uw	4655	15	non	non	NNS
cord-001835-0s7ok4uw	4655	16	-	-	NNS
cord-001835-0s7ok4uw	4655	17	specialists	specialist	NNS
cord-001835-0s7ok4uw	4655	18	:	:	:
cord-001835-0s7ok4uw	4655	19	CABS	cab	NNS
cord-001835-0s7ok4uw	4655	20	-	-	HYPH
cord-001835-0s7ok4uw	4655	21	fold	fold	JJ
cord-001835-0s7ok4uw	4655	22	server	server	NN
cord-001835-0s7ok4uw	4655	23	for	for	IN
cord-001835-0s7ok4uw	4655	24	protein	protein	NN
cord-001835-0s7ok4uw	4655	25	structure	structure	NN
cord-001835-0s7ok4uw	4655	26	prediction	prediction	NN
cord-001835-0s7ok4uw	4655	27	[	[	-LRB-
cord-001835-0s7ok4uw	4655	28	1	1	CD
cord-001835-0s7ok4uw	4655	29	]	]	-RRB-
cord-001835-0s7ok4uw	4655	30	;	;	:
cord-001835-0s7ok4uw	4655	31	CABS	cab	NNS
cord-001835-0s7ok4uw	4655	32	-	-	HYPH
cord-001835-0s7ok4uw	4655	33	flex	flex	JJ
cord-001835-0s7ok4uw	4655	34	server	server	NN
cord-001835-0s7ok4uw	4655	35	for	for	IN
cord-001835-0s7ok4uw	4655	36	modeling	modeling	NN
cord-001835-0s7ok4uw	4655	37	of	of	IN
cord-001835-0s7ok4uw	4655	38	protein	protein	NN
cord-001835-0s7ok4uw	4655	39	structure	structure	NN
cord-001835-0s7ok4uw	4655	40	flexibility	flexibility	NN
cord-001835-0s7ok4uw	4655	41	[	[	-LRB-
cord-001835-0s7ok4uw	4655	42	2	2	CD
cord-001835-0s7ok4uw	4655	43	]	]	-RRB-
cord-001835-0s7ok4uw	4655	44	;	;	:
cord-001835-0s7ok4uw	4655	45	Aggrescan3D	aggrescan3d	NN
cord-001835-0s7ok4uw	4655	46	server	server	NN
cord-001835-0s7ok4uw	4655	47	for	for	IN
cord-001835-0s7ok4uw	4655	48	prediction	prediction	NN
cord-001835-0s7ok4uw	4655	49	of	of	IN
cord-001835-0s7ok4uw	4655	50	protein	protein	NN
cord-001835-0s7ok4uw	4655	51	aggregation	aggregation	NN
cord-001835-0s7ok4uw	4655	52	propensities	propensity	NNS
cord-001835-0s7ok4uw	4655	53	and	and	CC
cord-001835-0s7ok4uw	4655	54	rational	rational	JJ
cord-001835-0s7ok4uw	4655	55	design	design	NN
cord-001835-0s7ok4uw	4655	56	of	of	IN
cord-001835-0s7ok4uw	4655	57	protein	protein	NN
cord-001835-0s7ok4uw	4655	58	solubility	solubility	NN
cord-001835-0s7ok4uw	4655	59	[	[	-LRB-
cord-001835-0s7ok4uw	4655	60	3	3	CD
cord-001835-0s7ok4uw	4655	61	]	]	-RRB-
cord-001835-0s7ok4uw	4655	62	;	;	:
cord-001835-0s7ok4uw	4655	63	and	and	CC
cord-001835-0s7ok4uw	4655	64	CABS	cab	NNS
cord-001835-0s7ok4uw	4655	65	-	-	HYPH
cord-001835-0s7ok4uw	4655	66	dock	dock	NN
cord-001835-0s7ok4uw	4655	67	server	server	NN
cord-001835-0s7ok4uw	4655	68	for	for	IN
cord-001835-0s7ok4uw	4655	69	prediction	prediction	NN
cord-001835-0s7ok4uw	4655	70	of	of	IN
cord-001835-0s7ok4uw	4655	71	peptide	peptide	NN
cord-001835-0s7ok4uw	4655	72	binding	bind	VBG
cord-001835-0s7ok4uw	4655	73	sites	site	NNS
cord-001835-0s7ok4uw	4655	74	and	and	CC
cord-001835-0s7ok4uw	4655	75	peptide	peptide	NN
cord-001835-0s7ok4uw	4655	76	docking	docking	NN
cord-001835-0s7ok4uw	4655	77	[	[	-LRB-
cord-001835-0s7ok4uw	4655	78	4	4	CD
cord-001835-0s7ok4uw	4655	79	]	]	-RRB-
cord-001835-0s7ok4uw	4655	80	.	.	.
cord-001835-0s7ok4uw	4656	1	The	the	DT
cord-001835-0s7ok4uw	4656	2	web	web	NN
cord-001835-0s7ok4uw	4656	3	servers	server	NNS
cord-001835-0s7ok4uw	4656	4	are	be	VBP
cord-001835-0s7ok4uw	4656	5	freely	freely	RB
cord-001835-0s7ok4uw	4656	6	available	available	JJ
cord-001835-0s7ok4uw	4656	7	from	from	IN
cord-001835-0s7ok4uw	4656	8	the	the	DT
cord-001835-0s7ok4uw	4656	9	laboratory	laboratory	NN
cord-001835-0s7ok4uw	4656	10	website	website	NN
cord-001835-0s7ok4uw	4656	11	:	:	:
cord-001835-0s7ok4uw	4657	1	http://biocomp.chem.uw.edu.pl/tools	http://biocomp.chem.uw.edu.pl/tools	ADD
cord-001835-0s7ok4uw	4657	2	Sandy	Sandy	NNP
cord-001835-0s7ok4uw	4658	1	On	on	IN
cord-001835-0s7ok4uw	4658	2	1	1	CD
cord-001835-0s7ok4uw	4658	3	,	,	,
cord-001835-0s7ok4uw	4658	4	Pinghui	Pinghui	NNP
cord-001835-0s7ok4uw	4658	5	Feng	Feng	NNP
cord-001835-0s7ok4uw	4658	6	2	2	CD
cord-001835-0s7ok4uw	4658	7	1	1	CD
cord-001835-0s7ok4uw	4658	8	University	University	NNP
cord-001835-0s7ok4uw	4658	9	of	of	IN
cord-001835-0s7ok4uw	4658	10	Southern	Southern	NNP
cord-001835-0s7ok4uw	4658	11	California	California	NNP
cord-001835-0s7ok4uw	4658	12	,	,	,
cord-001835-0s7ok4uw	4658	13	Keck	Keck	NNP
cord-001835-0s7ok4uw	4658	14	School	School	NNP
cord-001835-0s7ok4uw	4658	15	of	of	IN
cord-001835-0s7ok4uw	4658	16	Medicine	Medicine	NNP
cord-001835-0s7ok4uw	4658	17	,	,	,
cord-001835-0s7ok4uw	4658	18	2	2	CD
cord-001835-0s7ok4uw	4658	19	 	 	_SP
cord-001835-0s7ok4uw	4658	20	Developing	develop	VBG
cord-001835-0s7ok4uw	4658	21	a	a	DT
cord-001835-0s7ok4uw	4658	22	Technique	technique	NN
cord-001835-0s7ok4uw	4658	23	to	to	TO
cord-001835-0s7ok4uw	4658	24	Detect	detect	VB
cord-001835-0s7ok4uw	4658	25	Deamidated	Deamidated	NNP
cord-001835-0s7ok4uw	4658	26	Proteins	Proteins	NNPS
cord-001835-0s7ok4uw	4658	27	and	and	CC
cord-001835-0s7ok4uw	4658	28	Peptides	peptide	NNS
cord-001835-0s7ok4uw	4659	1	Using	use	VBG
cord-001835-0s7ok4uw	4659	2	Rig-	rig-	CD
cord-001835-0s7ok4uw	4660	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	4660	2	Sandy	Sandy	NNP
cord-001835-0s7ok4uw	4661	1	On	on	IN
cord-001835-0s7ok4uw	4661	2	,	,	,
cord-001835-0s7ok4uw	4661	3	Pinghui	Pinghui	NNP
cord-001835-0s7ok4uw	4661	4	Feng	Feng	NNP
cord-001835-0s7ok4uw	4661	5	University	University	NNP
cord-001835-0s7ok4uw	4661	6	of	of	IN
cord-001835-0s7ok4uw	4661	7	Southern	Southern	NNP
cord-001835-0s7ok4uw	4661	8	California	California	NNP
cord-001835-0s7ok4uw	4661	9	,	,	,
cord-001835-0s7ok4uw	4661	10	Norris	Norris	NNP
cord-001835-0s7ok4uw	4661	11	Comprehensive	Comprehensive	NNP
cord-001835-0s7ok4uw	4661	12	Cancer	Cancer	NNP
cord-001835-0s7ok4uw	4661	13	Center	Center	NNP
cord-001835-0s7ok4uw	4661	14	,	,	,
cord-001835-0s7ok4uw	4661	15	Department	Department	NNP
cord-001835-0s7ok4uw	4661	16	of	of	IN
cord-001835-0s7ok4uw	4661	17	Microbiology	Microbiology	NNP
cord-001835-0s7ok4uw	4661	18	,	,	,
cord-001835-0s7ok4uw	4661	19	and	and	CC
cord-001835-0s7ok4uw	4661	20	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	4661	21	Biology	Biology	NNP
cord-001835-0s7ok4uw	4661	22	,	,	,
cord-001835-0s7ok4uw	4661	23	Los	Los	NNP
cord-001835-0s7ok4uw	4661	24	Angeles	Angeles	NNP
cord-001835-0s7ok4uw	4661	25	CA	CA	NNP
cord-001835-0s7ok4uw	4662	1	Perhaps	perhaps	RB
cord-001835-0s7ok4uw	4662	2	the	the	DT
cord-001835-0s7ok4uw	4662	3	most	most	RBS
cord-001835-0s7ok4uw	4662	4	notable	notable	JJ
cord-001835-0s7ok4uw	4662	5	type	type	NN
cord-001835-0s7ok4uw	4662	6	of	of	IN
cord-001835-0s7ok4uw	4662	7	post	post	JJ
cord-001835-0s7ok4uw	4662	8	-	-	JJ
cord-001835-0s7ok4uw	4662	9	translational	translational	JJ
cord-001835-0s7ok4uw	4662	10	modification	modification	NN
cord-001835-0s7ok4uw	4662	11	of	of	IN
cord-001835-0s7ok4uw	4662	12	proteins	protein	NNS
cord-001835-0s7ok4uw	4662	13	and	and	CC
cord-001835-0s7ok4uw	4662	14	peptides	peptide	NNS
cord-001835-0s7ok4uw	4662	15	into	into	IN
cord-001835-0s7ok4uw	4662	16	a	a	DT
cord-001835-0s7ok4uw	4662	17	higher	high	JJR
cord-001835-0s7ok4uw	4662	18	order	order	NN
cord-001835-0s7ok4uw	4662	19	structure	structure	NN
cord-001835-0s7ok4uw	4662	20	is	be	VBZ
cord-001835-0s7ok4uw	4662	21	deamidation	deamidation	NN
cord-001835-0s7ok4uw	4662	22	of	of	IN
cord-001835-0s7ok4uw	4662	23	asparagine	asparagine	NN
cord-001835-0s7ok4uw	4662	24	and	and	CC
cord-001835-0s7ok4uw	4662	25	glutamine	glutamine	NN
cord-001835-0s7ok4uw	4662	26	.	.	.
cord-001835-0s7ok4uw	4663	1	Deamidation	deamidation	NN
cord-001835-0s7ok4uw	4663	2	occurs	occur	VBZ
cord-001835-0s7ok4uw	4663	3	when	when	WRB
cord-001835-0s7ok4uw	4663	4	an	an	DT
cord-001835-0s7ok4uw	4663	5	amine	amine	NN
cord-001835-0s7ok4uw	4663	6	group	group	NN
cord-001835-0s7ok4uw	4663	7	is	be	VBZ
cord-001835-0s7ok4uw	4663	8	removed	remove	VBN
cord-001835-0s7ok4uw	4663	9	,	,	,
cord-001835-0s7ok4uw	4663	10	degrading	degrade	VBG
cord-001835-0s7ok4uw	4663	11	the	the	DT
cord-001835-0s7ok4uw	4663	12	molecule	molecule	NN
cord-001835-0s7ok4uw	4663	13	for	for	IN
cord-001835-0s7ok4uw	4663	14	purpose	purpose	NN
cord-001835-0s7ok4uw	4663	15	of	of	IN
cord-001835-0s7ok4uw	4663	16	regulating	regulate	VBG
cord-001835-0s7ok4uw	4663	17	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	4663	18	levels	level	NNS
cord-001835-0s7ok4uw	4663	19	.	.	.
cord-001835-0s7ok4uw	4664	1	Previous	previous	JJ
cord-001835-0s7ok4uw	4664	2	studies	study	NNS
cord-001835-0s7ok4uw	4664	3	have	have	VBP
cord-001835-0s7ok4uw	4664	4	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	4664	5	that	that	IN
cord-001835-0s7ok4uw	4664	6	this	this	DT
cord-001835-0s7ok4uw	4664	7	notable	notable	JJ
cord-001835-0s7ok4uw	4664	8	post	post	JJ
cord-001835-0s7ok4uw	4664	9	translational	translational	JJ
cord-001835-0s7ok4uw	4664	10	modification	modification	NN
cord-001835-0s7ok4uw	4664	11	has	have	VBZ
cord-001835-0s7ok4uw	4664	12	been	be	VBN
cord-001835-0s7ok4uw	4664	13	uncovered	uncover	VBN
cord-001835-0s7ok4uw	4664	14	over	over	IN
cord-001835-0s7ok4uw	4664	15	time	time	NN
cord-001835-0s7ok4uw	4664	16	for	for	IN
cord-001835-0s7ok4uw	4664	17	use	use	NN
cord-001835-0s7ok4uw	4664	18	in	in	IN
cord-001835-0s7ok4uw	4664	19	DNA	dna	NN
cord-001835-0s7ok4uw	4664	20	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	4664	21	technology	technology	NN
cord-001835-0s7ok4uw	4664	22	as	as	RB
cord-001835-0s7ok4uw	4664	23	well	well	RB
cord-001835-0s7ok4uw	4664	24	as	as	IN
cord-001835-0s7ok4uw	4664	25	use	use	NN
cord-001835-0s7ok4uw	4664	26	as	as	IN
cord-001835-0s7ok4uw	4664	27	a	a	DT
cord-001835-0s7ok4uw	4664	28	biological	biological	JJ
cord-001835-0s7ok4uw	4664	29	clock	clock	NN
cord-001835-0s7ok4uw	4664	30	to	to	TO
cord-001835-0s7ok4uw	4664	31	facilitate	facilitate	VB
cord-001835-0s7ok4uw	4664	32	the	the	DT
cord-001835-0s7ok4uw	4664	33	rapid	rapid	JJ
cord-001835-0s7ok4uw	4664	34	turnover	turnover	NN
cord-001835-0s7ok4uw	4664	35	of	of	IN
cord-001835-0s7ok4uw	4664	36	biologically	biologically	RB
cord-001835-0s7ok4uw	4664	37	important	important	JJ
cord-001835-0s7ok4uw	4664	38	components	component	NNS
cord-001835-0s7ok4uw	4664	39	of	of	IN
cord-001835-0s7ok4uw	4664	40	the	the	DT
cord-001835-0s7ok4uw	4664	41	cell	cell	NN
cord-001835-0s7ok4uw	4664	42	.	.	.
cord-001835-0s7ok4uw	4665	1	While	while	IN
cord-001835-0s7ok4uw	4665	2	the	the	DT
cord-001835-0s7ok4uw	4665	3	effects	effect	NNS
cord-001835-0s7ok4uw	4665	4	of	of	IN
cord-001835-0s7ok4uw	4665	5	this	this	DT
cord-001835-0s7ok4uw	4665	6	non	non	JJ
cord-001835-0s7ok4uw	4665	7	-	-	JJ
cord-001835-0s7ok4uw	4665	8	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	4665	9	chemical	chemical	NN
cord-001835-0s7ok4uw	4665	10	reaction	reaction	NN
cord-001835-0s7ok4uw	4665	11	have	have	VBP
cord-001835-0s7ok4uw	4665	12	been	be	VBN
cord-001835-0s7ok4uw	4665	13	widely	widely	RB
cord-001835-0s7ok4uw	4665	14	studied	study	VBN
cord-001835-0s7ok4uw	4665	15	,	,	,
cord-001835-0s7ok4uw	4665	16	the	the	DT
cord-001835-0s7ok4uw	4665	17	method	method	NN
cord-001835-0s7ok4uw	4665	18	to	to	TO
cord-001835-0s7ok4uw	4665	19	uncover	uncover	VB
cord-001835-0s7ok4uw	4665	20	modification	modification	NN
cord-001835-0s7ok4uw	4665	21	sites	site	NNS
cord-001835-0s7ok4uw	4665	22	over	over	IN
cord-001835-0s7ok4uw	4665	23	a	a	DT
cord-001835-0s7ok4uw	4665	24	large	large	JJ
cord-001835-0s7ok4uw	4665	25	quantity	quantity	NN
cord-001835-0s7ok4uw	4665	26	of	of	IN
cord-001835-0s7ok4uw	4665	27	proteins	protein	NNS
cord-001835-0s7ok4uw	4665	28	remains	remain	VBZ
cord-001835-0s7ok4uw	4665	29	an	an	DT
cord-001835-0s7ok4uw	4665	30	issue	issue	NN
cord-001835-0s7ok4uw	4665	31	.	.	.
cord-001835-0s7ok4uw	4666	1	One	one	CD
cord-001835-0s7ok4uw	4666	2	of	of	IN
cord-001835-0s7ok4uw	4666	3	the	the	DT
cord-001835-0s7ok4uw	4666	4	most	most	RBS
cord-001835-0s7ok4uw	4666	5	common	common	JJ
cord-001835-0s7ok4uw	4666	6	types	type	NNS
cord-001835-0s7ok4uw	4666	7	of	of	IN
cord-001835-0s7ok4uw	4666	8	deamidation	deamidation	NN
cord-001835-0s7ok4uw	4666	9	is	be	VBZ
cord-001835-0s7ok4uw	4666	10	of	of	IN
cord-001835-0s7ok4uw	4666	11	asparagine	asparagine	NN
cord-001835-0s7ok4uw	4666	12	and	and	CC
cord-001835-0s7ok4uw	4666	13	glutamine	glutamine	NN
cord-001835-0s7ok4uw	4666	14	residues	residue	NNS
cord-001835-0s7ok4uw	4666	15	.	.	.
cord-001835-0s7ok4uw	4667	1	At	at	IN
cord-001835-0s7ok4uw	4667	2	this	this	DT
cord-001835-0s7ok4uw	4667	3	time	time	NN
cord-001835-0s7ok4uw	4667	4	,	,	,
cord-001835-0s7ok4uw	4667	5	most	most	JJS
cord-001835-0s7ok4uw	4667	6	researchers	researcher	NNS
cord-001835-0s7ok4uw	4667	7	will	will	MD
cord-001835-0s7ok4uw	4667	8	depend	depend	VB
cord-001835-0s7ok4uw	4667	9	on	on	IN
cord-001835-0s7ok4uw	4667	10	mass	mass	NNP
cord-001835-0s7ok4uw	4667	11	spectrometric	spectrometric	NNP
cord-001835-0s7ok4uw	4667	12	based	base	VBN
cord-001835-0s7ok4uw	4667	13	proteomic	proteomic	JJ
cord-001835-0s7ok4uw	4667	14	techniques	technique	NNS
cord-001835-0s7ok4uw	4667	15	for	for	IN
cord-001835-0s7ok4uw	4667	16	identification	identification	NN
cord-001835-0s7ok4uw	4667	17	of	of	IN
cord-001835-0s7ok4uw	4667	18	these	these	DT
cord-001835-0s7ok4uw	4667	19	post	post	JJ
cord-001835-0s7ok4uw	4667	20	-	-	JJ
cord-001835-0s7ok4uw	4667	21	translational	translational	JJ
cord-001835-0s7ok4uw	4667	22	sites	site	NNS
cord-001835-0s7ok4uw	4667	23	.	.	.
cord-001835-0s7ok4uw	4668	1	The	the	DT
cord-001835-0s7ok4uw	4668	2	issue	issue	NN
cord-001835-0s7ok4uw	4668	3	is	be	VBZ
cord-001835-0s7ok4uw	4668	4	that	that	IN
cord-001835-0s7ok4uw	4668	5	mass	mass	JJ
cord-001835-0s7ok4uw	4668	6	spectral	spectral	JJ
cord-001835-0s7ok4uw	4668	7	analysis	analysis	NN
cord-001835-0s7ok4uw	4668	8	of	of	IN
cord-001835-0s7ok4uw	4668	9	deamidated	deamidated	JJ
cord-001835-0s7ok4uw	4668	10	proteins	protein	NNS
cord-001835-0s7ok4uw	4668	11	and	and	CC
cord-001835-0s7ok4uw	4668	12	peptides	peptide	NNS
cord-001835-0s7ok4uw	4668	13	is	be	VBZ
cord-001835-0s7ok4uw	4668	14	complication	complication	NN
cord-001835-0s7ok4uw	4668	15	and	and	CC
cord-001835-0s7ok4uw	4668	16	can	can	MD
cord-001835-0s7ok4uw	4668	17	lead	lead	VB
cord-001835-0s7ok4uw	4668	18	to	to	IN
cord-001835-0s7ok4uw	4668	19	misassigned	misassigne	VBN
cord-001835-0s7ok4uw	4668	20	identification	identification	NN
cord-001835-0s7ok4uw	4668	21	attributed	attribute	VBN
cord-001835-0s7ok4uw	4668	22	by	by	IN
cord-001835-0s7ok4uw	4668	23	an	an	DT
cord-001835-0s7ok4uw	4668	24	overlapping	overlapping	NN
cord-001835-0s7ok4uw	4668	25	of	of	IN
cord-001835-0s7ok4uw	4668	26	13C	13c	CD
cord-001835-0s7ok4uw	4668	27	peak	peak	NN
cord-001835-0s7ok4uw	4668	28	of	of	IN
cord-001835-0s7ok4uw	4668	29	the	the	DT
cord-001835-0s7ok4uw	4668	30	amidated	amidate	VBN
cord-001835-0s7ok4uw	4668	31	form	form	NN
cord-001835-0s7ok4uw	4668	32	with	with	IN
cord-001835-0s7ok4uw	4668	33	the	the	DT
cord-001835-0s7ok4uw	4668	34	deamidated	deamidate	VBN
cord-001835-0s7ok4uw	4668	35	monoisotopic	monoisotopic	NNP
cord-001835-0s7ok4uw	4668	36	peak	peak	NN
cord-001835-0s7ok4uw	4668	37	;	;	:
cord-001835-0s7ok4uw	4668	38	these	these	DT
cord-001835-0s7ok4uw	4668	39	two	two	CD
cord-001835-0s7ok4uw	4668	40	peaks	peak	NNS
cord-001835-0s7ok4uw	4668	41	are	be	VBP
cord-001835-0s7ok4uw	4668	42	only	only	RB
cord-001835-0s7ok4uw	4668	43	separated	separate	VBN
cord-001835-0s7ok4uw	4668	44	by	by	IN
cord-001835-0s7ok4uw	4668	45	19.34	19.34	CD
cord-001835-0s7ok4uw	4668	46	mDa	mDa	NNS
cord-001835-0s7ok4uw	4668	47	.	.	.
cord-001835-0s7ok4uw	4669	1	While	while	IN
cord-001835-0s7ok4uw	4669	2	these	these	DT
cord-001835-0s7ok4uw	4669	3	issues	issue	NNS
cord-001835-0s7ok4uw	4669	4	can	can	MD
cord-001835-0s7ok4uw	4669	5	be	be	VB
cord-001835-0s7ok4uw	4669	6	mediated	mediate	VBN
cord-001835-0s7ok4uw	4669	7	by	by	IN
cord-001835-0s7ok4uw	4669	8	using	use	VBG
cord-001835-0s7ok4uw	4669	9	a	a	DT
cord-001835-0s7ok4uw	4669	10	mass	mass	NN
cord-001835-0s7ok4uw	4669	11	spectrometer	spectrometer	NN
cord-001835-0s7ok4uw	4669	12	with	with	IN
cord-001835-0s7ok4uw	4669	13	a	a	DT
cord-001835-0s7ok4uw	4669	14	high	high	JJ
cord-001835-0s7ok4uw	4669	15	mass	mass	NN
cord-001835-0s7ok4uw	4669	16	measurement	measurement	NN
cord-001835-0s7ok4uw	4669	17	accuracy	accuracy	NN
cord-001835-0s7ok4uw	4669	18	,	,	,
cord-001835-0s7ok4uw	4669	19	and	and	CC
cord-001835-0s7ok4uw	4669	20	high	high	JJ
cord-001835-0s7ok4uw	4669	21	resolving	resolve	VBG
cord-001835-0s7ok4uw	4669	22	power	power	NN
cord-001835-0s7ok4uw	4669	23	,	,	,
cord-001835-0s7ok4uw	4669	24	it	-PRON-	PRP
cord-001835-0s7ok4uw	4669	25	is	be	VBZ
cord-001835-0s7ok4uw	4669	26	essential	essential	JJ
cord-001835-0s7ok4uw	4669	27	to	to	TO
cord-001835-0s7ok4uw	4669	28	establish	establish	VB
cord-001835-0s7ok4uw	4669	29	simpler	simple	JJR
cord-001835-0s7ok4uw	4669	30	methods	method	NNS
cord-001835-0s7ok4uw	4669	31	for	for	IN
cord-001835-0s7ok4uw	4669	32	identifying	identify	VBG
cord-001835-0s7ok4uw	4669	33	substrates	substrate	NNS
cord-001835-0s7ok4uw	4669	34	that	that	WDT
cord-001835-0s7ok4uw	4669	35	have	have	VBP
cord-001835-0s7ok4uw	4669	36	undergone	undergo	VBN
cord-001835-0s7ok4uw	4669	37	deamidation	deamidation	NN
cord-001835-0s7ok4uw	4669	38	.	.	.
cord-001835-0s7ok4uw	4670	1	If	if	IN
cord-001835-0s7ok4uw	4670	2	deamidation	deamidation	NN
cord-001835-0s7ok4uw	4670	3	is	be	VBZ
cord-001835-0s7ok4uw	4670	4	present	present	JJ
cord-001835-0s7ok4uw	4670	5	,	,	,
cord-001835-0s7ok4uw	4670	6	different	different	JJ
cord-001835-0s7ok4uw	4670	7	protein	protein	NN
cord-001835-0s7ok4uw	4670	8	bands	band	NNS
cord-001835-0s7ok4uw	4670	9	will	will	MD
cord-001835-0s7ok4uw	4670	10	be	be	VB
cord-001835-0s7ok4uw	4670	11	exhibited	exhibit	VBN
cord-001835-0s7ok4uw	4670	12	in	in	IN
cord-001835-0s7ok4uw	4670	13	the	the	DT
cord-001835-0s7ok4uw	4670	14	western	western	JJ
cord-001835-0s7ok4uw	4670	15	blot	blot	NN
cord-001835-0s7ok4uw	4670	16	,	,	,
cord-001835-0s7ok4uw	4670	17	which	which	WDT
cord-001835-0s7ok4uw	4670	18	will	will	MD
cord-001835-0s7ok4uw	4670	19	be	be	VB
cord-001835-0s7ok4uw	4670	20	compared	compare	VBN
cord-001835-0s7ok4uw	4670	21	to	to	IN
cord-001835-0s7ok4uw	4670	22	a	a	DT
cord-001835-0s7ok4uw	4670	23	triple	triple	JJ
cord-001835-0s7ok4uw	4670	24	mutant	mutant	JJ
cord-001835-0s7ok4uw	4670	25	RIG	rig	NN
cord-001835-0s7ok4uw	4670	26	-	-	:
cord-001835-0s7ok4uw	4670	27	I	I	NNP
cord-001835-0s7ok4uw	4670	28	,	,	,
cord-001835-0s7ok4uw	4670	29	which	which	WDT
cord-001835-0s7ok4uw	4670	30	resists	resist	VBZ
cord-001835-0s7ok4uw	4670	31	deamidation	deamidation	NN
cord-001835-0s7ok4uw	4670	32	,	,	,
cord-001835-0s7ok4uw	4670	33	to	to	TO
cord-001835-0s7ok4uw	4670	34	observe	observe	VB
cord-001835-0s7ok4uw	4670	35	the	the	DT
cord-001835-0s7ok4uw	4670	36	location	location	NN
cord-001835-0s7ok4uw	4670	37	of	of	IN
cord-001835-0s7ok4uw	4670	38	this	this	DT
cord-001835-0s7ok4uw	4670	39	modification	modification	NN
cord-001835-0s7ok4uw	4670	40	on	on	IN
cord-001835-0s7ok4uw	4670	41	the	the	DT
cord-001835-0s7ok4uw	4670	42	protein	protein	NN
cord-001835-0s7ok4uw	4670	43	.	.	.
cord-001835-0s7ok4uw	4671	1	With	with	IN
cord-001835-0s7ok4uw	4671	2	enough	enough	JJ
cord-001835-0s7ok4uw	4671	3	testing	testing	NN
cord-001835-0s7ok4uw	4671	4	,	,	,
cord-001835-0s7ok4uw	4671	5	I	-PRON-	PRP
cord-001835-0s7ok4uw	4671	6	will	will	MD
cord-001835-0s7ok4uw	4671	7	determine	determine	VB
cord-001835-0s7ok4uw	4671	8	specific	specific	JJ
cord-001835-0s7ok4uw	4671	9	sites	site	NNS
cord-001835-0s7ok4uw	4671	10	of	of	IN
cord-001835-0s7ok4uw	4671	11	digestion	digestion	NN
cord-001835-0s7ok4uw	4671	12	and	and	CC
cord-001835-0s7ok4uw	4671	13	use	use	VB
cord-001835-0s7ok4uw	4671	14	this	this	DT
cord-001835-0s7ok4uw	4671	15	information	information	NN
cord-001835-0s7ok4uw	4671	16	to	to	TO
cord-001835-0s7ok4uw	4671	17	make	make	VB
cord-001835-0s7ok4uw	4671	18	conclusions	conclusion	NNS
cord-001835-0s7ok4uw	4671	19	of	of	IN
cord-001835-0s7ok4uw	4671	20	unknown	unknown	JJ
cord-001835-0s7ok4uw	4671	21	proteins	protein	NNS
cord-001835-0s7ok4uw	4671	22	.	.	.
cord-001835-0s7ok4uw	4672	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	4672	2	will	will	MD
cord-001835-0s7ok4uw	4672	3	make	make	VB
cord-001835-0s7ok4uw	4672	4	results	result	NNS
cord-001835-0s7ok4uw	4672	5	regarding	regard	VBG
cord-001835-0s7ok4uw	4672	6	whether	whether	IN
cord-001835-0s7ok4uw	4672	7	the	the	DT
cord-001835-0s7ok4uw	4672	8	protein	protein	NN
cord-001835-0s7ok4uw	4672	9	has	have	VBZ
cord-001835-0s7ok4uw	4672	10	been	be	VBN
cord-001835-0s7ok4uw	4672	11	modified	modify	VBN
cord-001835-0s7ok4uw	4672	12	based	base	VBN
cord-001835-0s7ok4uw	4672	13	on	on	IN
cord-001835-0s7ok4uw	4672	14	the	the	DT
cord-001835-0s7ok4uw	4672	15	digestion	digestion	NN
cord-001835-0s7ok4uw	4672	16	sites	site	NNS
cord-001835-0s7ok4uw	4672	17	.	.	.
cord-001835-0s7ok4uw	4673	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	4673	2	will	will	MD
cord-001835-0s7ok4uw	4673	3	use	use	VB
cord-001835-0s7ok4uw	4673	4	mass	mass	JJ
cord-001835-0s7ok4uw	4673	5	spectrophotometry	spectrophotometry	NN
cord-001835-0s7ok4uw	4673	6	analysis	analysis	NN
cord-001835-0s7ok4uw	4673	7	to	to	TO
cord-001835-0s7ok4uw	4673	8	compare	compare	VB
cord-001835-0s7ok4uw	4673	9	the	the	DT
cord-001835-0s7ok4uw	4673	10	proteins	protein	NNS
cord-001835-0s7ok4uw	4673	11	on	on	IN
cord-001835-0s7ok4uw	4673	12	a	a	DT
cord-001835-0s7ok4uw	4673	13	wider	wide	JJR
cord-001835-0s7ok4uw	4673	14	scale	scale	NN
cord-001835-0s7ok4uw	4673	15	and	and	CC
cord-001835-0s7ok4uw	4673	16	double	double	JJ
cord-001835-0s7ok4uw	4673	17	check	check	VB
cord-001835-0s7ok4uw	4673	18	my	-PRON-	PRP$
cord-001835-0s7ok4uw	4673	19	results	result	NNS
cord-001835-0s7ok4uw	4673	20	.	.	.
cord-001835-0s7ok4uw	4674	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	4674	2	have	have	VBP
cord-001835-0s7ok4uw	4674	3	narrowed	narrow	VBN
cord-001835-0s7ok4uw	4674	4	it	-PRON-	PRP
cord-001835-0s7ok4uw	4674	5	down	down	RP
cord-001835-0s7ok4uw	4674	6	to	to	IN
cord-001835-0s7ok4uw	4674	7	a	a	DT
cord-001835-0s7ok4uw	4674	8	couple	couple	NN
cord-001835-0s7ok4uw	4674	9	of	of	IN
cord-001835-0s7ok4uw	4674	10	different	different	JJ
cord-001835-0s7ok4uw	4674	11	digestion	digestion	NN
cord-001835-0s7ok4uw	4674	12	sites	site	NNS
cord-001835-0s7ok4uw	4674	13	that	that	WDT
cord-001835-0s7ok4uw	4674	14	indicate	indicate	VBP
cord-001835-0s7ok4uw	4674	15	deamidation	deamidation	NN
cord-001835-0s7ok4uw	4674	16	.	.	.
cord-001835-0s7ok4uw	4675	1	Though	though	IN
cord-001835-0s7ok4uw	4675	2	the	the	DT
cord-001835-0s7ok4uw	4675	3	analysis	analysis	NN
cord-001835-0s7ok4uw	4675	4	work	work	NN
cord-001835-0s7ok4uw	4675	5	can	can	MD
cord-001835-0s7ok4uw	4675	6	be	be	VB
cord-001835-0s7ok4uw	4675	7	tedious	tedious	JJ
cord-001835-0s7ok4uw	4675	8	,	,	,
cord-001835-0s7ok4uw	4675	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	4675	10	is	be	VBZ
cord-001835-0s7ok4uw	4675	11	crucial	crucial	JJ
cord-001835-0s7ok4uw	4675	12	to	to	TO
cord-001835-0s7ok4uw	4675	13	ensure	ensure	VB
cord-001835-0s7ok4uw	4675	14	the	the	DT
cord-001835-0s7ok4uw	4675	15	sites	site	NNS
cord-001835-0s7ok4uw	4675	16	we	-PRON-	PRP
cord-001835-0s7ok4uw	4675	17	isolate	isolate	VBP
cord-001835-0s7ok4uw	4675	18	are	be	VBP
cord-001835-0s7ok4uw	4675	19	accurate	accurate	JJ
cord-001835-0s7ok4uw	4675	20	in	in	IN
cord-001835-0s7ok4uw	4675	21	order	order	NN
cord-001835-0s7ok4uw	4675	22	to	to	TO
cord-001835-0s7ok4uw	4675	23	establish	establish	VB
cord-001835-0s7ok4uw	4675	24	this	this	DT
cord-001835-0s7ok4uw	4675	25	technique	technique	NN
cord-001835-0s7ok4uw	4675	26	.	.	.
cord-001835-0s7ok4uw	4676	1	From	from	IN
cord-001835-0s7ok4uw	4676	2	my	-PRON-	PRP$
cord-001835-0s7ok4uw	4676	3	research	research	NN
cord-001835-0s7ok4uw	4676	4	,	,	,
cord-001835-0s7ok4uw	4676	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4676	6	can	can	MD
cord-001835-0s7ok4uw	4676	7	apply	apply	VB
cord-001835-0s7ok4uw	4676	8	this	this	DT
cord-001835-0s7ok4uw	4676	9	method	method	NN
cord-001835-0s7ok4uw	4676	10	for	for	IN
cord-001835-0s7ok4uw	4676	11	wider	wide	JJR
cord-001835-0s7ok4uw	4676	12	scale	scale	NN
cord-001835-0s7ok4uw	4676	13	use	use	NN
cord-001835-0s7ok4uw	4676	14	such	such	JJ
cord-001835-0s7ok4uw	4676	15	as	as	IN
cord-001835-0s7ok4uw	4676	16	in	in	IN
cord-001835-0s7ok4uw	4676	17	clinical	clinical	JJ
cord-001835-0s7ok4uw	4676	18	settings	setting	NNS
cord-001835-0s7ok4uw	4676	19	.	.	.
cord-001835-0s7ok4uw	4677	1	In	in	IN
cord-001835-0s7ok4uw	4677	2	areas	area	NNS
cord-001835-0s7ok4uw	4677	3	of	of	IN
cord-001835-0s7ok4uw	4677	4	inflammation	inflammation	NN
cord-001835-0s7ok4uw	4677	5	of	of	IN
cord-001835-0s7ok4uw	4677	6	Parkinson	Parkinson	NNP
cord-001835-0s7ok4uw	4677	7	's	's	POS
cord-001835-0s7ok4uw	4677	8	'	'	``
cord-001835-0s7ok4uw	4677	9	patients	patient	NNS
cord-001835-0s7ok4uw	4677	10	,	,	,
cord-001835-0s7ok4uw	4677	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	4677	12	can	can	MD
cord-001835-0s7ok4uw	4677	13	review	review	VB
cord-001835-0s7ok4uw	4677	14	specifically	specifically	RB
cord-001835-0s7ok4uw	4677	15	the	the	DT
cord-001835-0s7ok4uw	4677	16	infected	infected	JJ
cord-001835-0s7ok4uw	4677	17	cells	cell	NNS
cord-001835-0s7ok4uw	4677	18	versus	versus	IN
cord-001835-0s7ok4uw	4677	19	uninfected	uninfected	JJ
cord-001835-0s7ok4uw	4677	20	and	and	CC
cord-001835-0s7ok4uw	4677	21	isolate	isolate	VB
cord-001835-0s7ok4uw	4677	22	the	the	DT
cord-001835-0s7ok4uw	4677	23	proteins	protein	NNS
cord-001835-0s7ok4uw	4677	24	,	,	,
cord-001835-0s7ok4uw	4677	25	usually	usually	RB
cord-001835-0s7ok4uw	4677	26	deamidated	deamidate	VBN
cord-001835-0s7ok4uw	4677	27	,	,	,
cord-001835-0s7ok4uw	4677	28	responsible	responsible	JJ
cord-001835-0s7ok4uw	4677	29	often	often	RB
cord-001835-0s7ok4uw	4677	30	smaller	small	JJR
cord-001835-0s7ok4uw	4677	31	in	in	IN
cord-001835-0s7ok4uw	4677	32	size	size	NN
cord-001835-0s7ok4uw	4677	33	and	and	CC
cord-001835-0s7ok4uw	4677	34	more	more	RBR
cord-001835-0s7ok4uw	4677	35	specific	specific	JJ
cord-001835-0s7ok4uw	4677	36	.	.	.
cord-001835-0s7ok4uw	4678	1	In	in	IN
cord-001835-0s7ok4uw	4678	2	addition	addition	NN
cord-001835-0s7ok4uw	4678	3	,	,	,
cord-001835-0s7ok4uw	4678	4	research	research	NN
cord-001835-0s7ok4uw	4678	5	articles	article	NNS
cord-001835-0s7ok4uw	4678	6	have	have	VBP
cord-001835-0s7ok4uw	4678	7	already	already	RB
cord-001835-0s7ok4uw	4678	8	shown	show	VBN
cord-001835-0s7ok4uw	4678	9	that	that	IN
cord-001835-0s7ok4uw	4678	10	suppressing	suppress	VBG
cord-001835-0s7ok4uw	4678	11	modification	modification	NN
cord-001835-0s7ok4uw	4678	12	of	of	IN
cord-001835-0s7ok4uw	4678	13	certain	certain	JJ
cord-001835-0s7ok4uw	4678	14	cells	cell	NNS
cord-001835-0s7ok4uw	4678	15	such	such	JJ
cord-001835-0s7ok4uw	4678	16	as	as	IN
cord-001835-0s7ok4uw	4678	17	Bcl	Bcl	NNP
cord-001835-0s7ok4uw	4678	18	-	-	HYPH
cord-001835-0s7ok4uw	4678	19	xl	xl	NNP
cord-001835-0s7ok4uw	4678	20	playing	play	VBG
cord-001835-0s7ok4uw	4678	21	a	a	DT
cord-001835-0s7ok4uw	4678	22	major	major	NN
cord-001835-0s7ok4uw	4678	23	in	in	IN
cord-001835-0s7ok4uw	4678	24	leading	lead	VBG
cord-001835-0s7ok4uw	4678	25	the	the	DT
cord-001835-0s7ok4uw	4678	26	regulation	regulation	NN
cord-001835-0s7ok4uw	4678	27	of	of	IN
cord-001835-0s7ok4uw	4678	28	cancer	cancer	NN
cord-001835-0s7ok4uw	4678	29	cell	cell	NN
cord-001835-0s7ok4uw	4678	30	death	death	NN
cord-001835-0s7ok4uw	4678	31	by	by	IN
cord-001835-0s7ok4uw	4678	32	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	4678	33	.	.	.
cord-001835-0s7ok4uw	4679	1	By	by	IN
cord-001835-0s7ok4uw	4679	2	leading	lead	VBG
cord-001835-0s7ok4uw	4679	3	the	the	DT
cord-001835-0s7ok4uw	4679	4	discovery	discovery	NN
cord-001835-0s7ok4uw	4679	5	of	of	IN
cord-001835-0s7ok4uw	4679	6	a	a	DT
cord-001835-0s7ok4uw	4679	7	simpler	simple	JJR
cord-001835-0s7ok4uw	4679	8	methods	method	NNS
cord-001835-0s7ok4uw	4679	9	to	to	IN
cord-001835-0s7ok4uw	4679	10	uncovering	uncover	VBG
cord-001835-0s7ok4uw	4679	11	deamidation	deamidation	NN
cord-001835-0s7ok4uw	4679	12	in	in	IN
cord-001835-0s7ok4uw	4679	13	cells	cell	NNS
cord-001835-0s7ok4uw	4679	14	,	,	,
cord-001835-0s7ok4uw	4679	15	researchers	researcher	NNS
cord-001835-0s7ok4uw	4679	16	will	will	MD
cord-001835-0s7ok4uw	4679	17	more	more	RBR
cord-001835-0s7ok4uw	4679	18	easily	easily	RB
cord-001835-0s7ok4uw	4679	19	and	and	CC
cord-001835-0s7ok4uw	4679	20	quickly	quickly	RB
cord-001835-0s7ok4uw	4679	21	be	be	VB
cord-001835-0s7ok4uw	4679	22	able	able	JJ
cord-001835-0s7ok4uw	4679	23	to	to	TO
cord-001835-0s7ok4uw	4679	24	scan	scan	VB
cord-001835-0s7ok4uw	4679	25	through	through	IN
cord-001835-0s7ok4uw	4679	26	various	various	JJ
cord-001835-0s7ok4uw	4679	27	proteins	protein	NNS
cord-001835-0s7ok4uw	4679	28	,	,	,
cord-001835-0s7ok4uw	4679	29	some	some	DT
cord-001835-0s7ok4uw	4679	30	of	of	IN
cord-001835-0s7ok4uw	4679	31	which	which	WDT
cord-001835-0s7ok4uw	4679	32	discovered	discover	VBD
cord-001835-0s7ok4uw	4679	33	eventually	eventually	RB
cord-001835-0s7ok4uw	4679	34	may	may	MD
cord-001835-0s7ok4uw	4679	35	play	play	VB
cord-001835-0s7ok4uw	4679	36	pivotal	pivotal	JJ
cord-001835-0s7ok4uw	4679	37	roles	role	NNS
cord-001835-0s7ok4uw	4679	38	in	in	IN
cord-001835-0s7ok4uw	4679	39	cancer	cancer	NN
cord-001835-0s7ok4uw	4679	40	research	research	NN
cord-001835-0s7ok4uw	4679	41	.	.	.
cord-001835-0s7ok4uw	4679	42	 	 	_SP
cord-001835-0s7ok4uw	4680	1	Influenza	influenza	NN
cord-001835-0s7ok4uw	4680	2	virus	virus	NN
cord-001835-0s7ok4uw	4680	3	(	(	-LRB-
cord-001835-0s7ok4uw	4680	4	IV	IV	NNP
cord-001835-0s7ok4uw	4680	5	)	)	-RRB-
cord-001835-0s7ok4uw	4680	6	hemagglutinin	hemagglutinin	NN
cord-001835-0s7ok4uw	4680	7	(	(	-LRB-
cord-001835-0s7ok4uw	4680	8	HA	HA	NNP
cord-001835-0s7ok4uw	4680	9	)	)	-RRB-
cord-001835-0s7ok4uw	4680	10	is	be	VBZ
cord-001835-0s7ok4uw	4680	11	a	a	DT
cord-001835-0s7ok4uw	4680	12	homotrimeric	homotrimeric	JJ
cord-001835-0s7ok4uw	4680	13	integral	integral	JJ
cord-001835-0s7ok4uw	4680	14	membrane	membrane	NN
cord-001835-0s7ok4uw	4680	15	glycoprotein	glycoprotein	NN
cord-001835-0s7ok4uw	4680	16	that	that	WDT
cord-001835-0s7ok4uw	4680	17	mediates	mediate	VBZ
cord-001835-0s7ok4uw	4680	18	receptor	receptor	NN
cord-001835-0s7ok4uw	4680	19	-	-	HYPH
cord-001835-0s7ok4uw	4680	20	binding	binding	NN
cord-001835-0s7ok4uw	4680	21	and	and	CC
cord-001835-0s7ok4uw	4680	22	membrane	membrane	NN
cord-001835-0s7ok4uw	4680	23	fusion	fusion	NN
cord-001835-0s7ok4uw	4680	24	.	.	.
cord-001835-0s7ok4uw	4681	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4681	2	constitutes	constitute	VBZ
cord-001835-0s7ok4uw	4681	3	the	the	DT
cord-001835-0s7ok4uw	4681	4	prominent	prominent	JJ
cord-001835-0s7ok4uw	4681	5	viral	viral	JJ
cord-001835-0s7ok4uw	4681	6	surface	surface	NN
cord-001835-0s7ok4uw	4681	7	antigen	antigen	NN
cord-001835-0s7ok4uw	4681	8	and	and	CC
cord-001835-0s7ok4uw	4681	9	a	a	DT
cord-001835-0s7ok4uw	4681	10	main	main	JJ
cord-001835-0s7ok4uw	4681	11	target	target	NN
cord-001835-0s7ok4uw	4681	12	for	for	IN
cord-001835-0s7ok4uw	4681	13	neutralizing	neutralize	VBG
cord-001835-0s7ok4uw	4681	14	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4681	15	.	.	.
cord-001835-0s7ok4uw	4682	1	Bacterial	bacterial	JJ
cord-001835-0s7ok4uw	4682	2	,	,	,
cord-001835-0s7ok4uw	4682	3	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	4682	4	HA	HA	NNP
cord-001835-0s7ok4uw	4682	5	-	-	HYPH
cord-001835-0s7ok4uw	4682	6	based	base	VBN
cord-001835-0s7ok4uw	4682	7	vaccines	vaccine	NNS
cord-001835-0s7ok4uw	4682	8	indicate	indicate	VBP
cord-001835-0s7ok4uw	4682	9	high	high	JJ
cord-001835-0s7ok4uw	4682	10	potential	potential	NN
cord-001835-0s7ok4uw	4682	11	to	to	TO
cord-001835-0s7ok4uw	4682	12	confer	confer	VB
cord-001835-0s7ok4uw	4682	13	protection	protection	NN
cord-001835-0s7ok4uw	4682	14	against	against	IN
cord-001835-0s7ok4uw	4682	15	highly	highly	RB
cord-001835-0s7ok4uw	4682	16	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	4682	17	(	(	-LRB-
cord-001835-0s7ok4uw	4682	18	HP	HP	NNP
cord-001835-0s7ok4uw	4682	19	)	)	-RRB-
cord-001835-0s7ok4uw	4682	20	avian	avian	JJ
cord-001835-0s7ok4uw	4682	21	IV	IV	NNP
cord-001835-0s7ok4uw	4682	22	(	(	-LRB-
cord-001835-0s7ok4uw	4682	23	AIV	AIV	NNP
cord-001835-0s7ok4uw	4682	24	)	)	-RRB-
cord-001835-0s7ok4uw	4682	25	H5N1	H5N1	NNP
cord-001835-0s7ok4uw	4682	26	and	and	CC
cord-001835-0s7ok4uw	4682	27	arise	arise	VB
cord-001835-0s7ok4uw	4682	28	as	as	IN
cord-001835-0s7ok4uw	4682	29	alternative	alternative	NN
cord-001835-0s7ok4uw	4682	30	for	for	IN
cord-001835-0s7ok4uw	4682	31	the	the	DT
cord-001835-0s7ok4uw	4682	32	traditional	traditional	JJ
cord-001835-0s7ok4uw	4682	33	egg	egg	NN
cord-001835-0s7ok4uw	4682	34	-	-	HYPH
cord-001835-0s7ok4uw	4682	35	or	or	CC
cord-001835-0s7ok4uw	4682	36	cell	cell	NN
cord-001835-0s7ok4uw	4682	37	culture	culture	NN
cord-001835-0s7ok4uw	4682	38	-	-	HYPH
cord-001835-0s7ok4uw	4682	39	based	base	VBN
cord-001835-0s7ok4uw	4682	40	manufacturing	manufacturing	NN
cord-001835-0s7ok4uw	4682	41	.	.	.
cord-001835-0s7ok4uw	4683	1	Relatively	relatively	RB
cord-001835-0s7ok4uw	4683	2	short	short	JJ
cord-001835-0s7ok4uw	4683	3	time	time	NN
cord-001835-0s7ok4uw	4683	4	of	of	IN
cord-001835-0s7ok4uw	4683	5	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	4683	6	HAs	have	VBZ
cord-001835-0s7ok4uw	4683	7	production	production	NN
cord-001835-0s7ok4uw	4683	8	can	can	MD
cord-001835-0s7ok4uw	4683	9	be	be	VB
cord-001835-0s7ok4uw	4683	10	of	of	IN
cord-001835-0s7ok4uw	4683	11	great	great	JJ
cord-001835-0s7ok4uw	4683	12	importance	importance	NN
cord-001835-0s7ok4uw	4683	13	in	in	IN
cord-001835-0s7ok4uw	4683	14	case	case	NN
cord-001835-0s7ok4uw	4683	15	of	of	IN
cord-001835-0s7ok4uw	4683	16	a	a	DT
cord-001835-0s7ok4uw	4683	17	pandemic	pandemic	NN
cord-001835-0s7ok4uw	4683	18	.	.	.
cord-001835-0s7ok4uw	4684	1	Escherichia	escherichia	NN
cord-001835-0s7ok4uw	4684	2	coli	coli	NNS
cord-001835-0s7ok4uw	4684	3	produced	produce	VBD
cord-001835-0s7ok4uw	4684	4	protein	protein	NN
cord-001835-0s7ok4uw	4684	5	,	,	,
cord-001835-0s7ok4uw	4684	6	based	base	VBN
cord-001835-0s7ok4uw	4684	7	on	on	IN
cord-001835-0s7ok4uw	4684	8	the	the	DT
cord-001835-0s7ok4uw	4684	9	HA	HA	NNP
cord-001835-0s7ok4uw	4684	10	sequence	sequence	NN
cord-001835-0s7ok4uw	4684	11	of	of	IN
cord-001835-0s7ok4uw	4684	12	A	a	NN
cord-001835-0s7ok4uw	4684	13	/	/	SYM
cord-001835-0s7ok4uw	4684	14	swan	swan	NN
cord-001835-0s7ok4uw	4684	15	/	/	SYM
cord-001835-0s7ok4uw	4684	16	Poland/305	Poland/305	NNP
cord-001835-0s7ok4uw	4684	17	-	-	HYPH
cord-001835-0s7ok4uw	4684	18	135V08/2006(H5N1	135V08/2006(H5N1	NNP
cord-001835-0s7ok4uw	4684	19	)	)	-RRB-
cord-001835-0s7ok4uw	4684	20	HPAIV	HPAIV	NNP
cord-001835-0s7ok4uw	4684	21	*	*	NFP
cord-001835-0s7ok4uw	4684	22	,	,	,
cord-001835-0s7ok4uw	4684	23	has	have	VBZ
cord-001835-0s7ok4uw	4684	24	been	be	VBN
cord-001835-0s7ok4uw	4684	25	successfully	successfully	RB
cord-001835-0s7ok4uw	4684	26	expressed	express	VBN
cord-001835-0s7ok4uw	4684	27	in	in	IN
cord-001835-0s7ok4uw	4684	28	the	the	DT
cord-001835-0s7ok4uw	4684	29	form	form	NN
cord-001835-0s7ok4uw	4684	30	of	of	IN
cord-001835-0s7ok4uw	4684	31	inclusion	inclusion	NN
cord-001835-0s7ok4uw	4684	32	bodies	body	NNS
cord-001835-0s7ok4uw	4684	33	at	at	IN
cord-001835-0s7ok4uw	4684	34	Institute	Institute	NNP
cord-001835-0s7ok4uw	4684	35	of	of	IN
cord-001835-0s7ok4uw	4684	36	Biotechnology	Biotechnology	NNP
cord-001835-0s7ok4uw	4684	37	and	and	CC
cord-001835-0s7ok4uw	4684	38	Antibiotics	Antibiotics	NNPS
cord-001835-0s7ok4uw	4684	39	.	.	.
cord-001835-0s7ok4uw	4685	1	Refolded	Refolded	NNP
cord-001835-0s7ok4uw	4685	2	and	and	CC
cord-001835-0s7ok4uw	4685	3	purified	purify	VBN
cord-001835-0s7ok4uw	4685	4	antigen	antigen	NN
cord-001835-0s7ok4uw	4685	5	was	be	VBD
cord-001835-0s7ok4uw	4685	6	obtained	obtain	VBN
cord-001835-0s7ok4uw	4685	7	in	in	IN
cord-001835-0s7ok4uw	4685	8	a	a	DT
cord-001835-0s7ok4uw	4685	9	soluble	soluble	JJ
cord-001835-0s7ok4uw	4685	10	form	form	NN
cord-001835-0s7ok4uw	4685	11	,	,	,
cord-001835-0s7ok4uw	4685	12	isolated	isolate	VBN
cord-001835-0s7ok4uw	4685	13	by	by	IN
cord-001835-0s7ok4uw	4685	14	reversed	reversed	JJ
cord-001835-0s7ok4uw	4685	15	phase	phase	NN
cord-001835-0s7ok4uw	4685	16	HPLC	HPLC	NNP
cord-001835-0s7ok4uw	4685	17	and	and	CC
cord-001835-0s7ok4uw	4685	18	identified	identify	VBN
cord-001835-0s7ok4uw	4685	19	with	with	IN
cord-001835-0s7ok4uw	4685	20	peptide	peptide	JJ
cord-001835-0s7ok4uw	4685	21	mass	mass	NN
cord-001835-0s7ok4uw	4685	22	fingerprinting	fingerprinting	NN
cord-001835-0s7ok4uw	4685	23	using	use	VBG
cord-001835-0s7ok4uw	4685	24	matrix	matrix	NN
cord-001835-0s7ok4uw	4685	25	-	-	HYPH
cord-001835-0s7ok4uw	4685	26	assisted	assist	VBN
cord-001835-0s7ok4uw	4685	27	laser	laser	NN
cord-001835-0s7ok4uw	4685	28	desorption	desorption	NN
cord-001835-0s7ok4uw	4685	29	/	/	SYM
cord-001835-0s7ok4uw	4685	30	ionization	ionization	NN
cord-001835-0s7ok4uw	4685	31	time	time	NN
cord-001835-0s7ok4uw	4685	32	of	of	IN
cord-001835-0s7ok4uw	4685	33	flight	flight	NN
cord-001835-0s7ok4uw	4685	34	mass	mass	NN
cord-001835-0s7ok4uw	4685	35	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4685	36	(	(	-LRB-
cord-001835-0s7ok4uw	4685	37	MALDI	MALDI	NNP
cord-001835-0s7ok4uw	4685	38	TOF	TOF	NNP
cord-001835-0s7ok4uw	4685	39	/	/	SYM
cord-001835-0s7ok4uw	4685	40	TOF	TOF	NNP
cord-001835-0s7ok4uw	4685	41	MS	MS	NNP
cord-001835-0s7ok4uw	4685	42	)	)	-RRB-
cord-001835-0s7ok4uw	4685	43	.	.	.
cord-001835-0s7ok4uw	4686	1	The	the	DT
cord-001835-0s7ok4uw	4686	2	performed	performed	JJ
cord-001835-0s7ok4uw	4686	3	research	research	NN
cord-001835-0s7ok4uw	4686	4	in	in	IN
cord-001835-0s7ok4uw	4686	5	a	a	DT
cord-001835-0s7ok4uw	4686	6	great	great	JJ
cord-001835-0s7ok4uw	4686	7	extent	extent	NN
cord-001835-0s7ok4uw	4686	8	allowed	allow	VBN
cord-001835-0s7ok4uw	4686	9	to	to	TO
cord-001835-0s7ok4uw	4686	10	confirm	confirm	VB
cord-001835-0s7ok4uw	4686	11	the	the	DT
cord-001835-0s7ok4uw	4686	12	amino	amino	NN
cord-001835-0s7ok4uw	4686	13	acid	acid	NN
cord-001835-0s7ok4uw	4686	14	sequence	sequence	NN
cord-001835-0s7ok4uw	4686	15	of	of	IN
cord-001835-0s7ok4uw	4686	16	the	the	DT
cord-001835-0s7ok4uw	4686	17	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	4686	18	HA	HA	NNP
cord-001835-0s7ok4uw	4686	19	(	(	-LRB-
cord-001835-0s7ok4uw	4686	20	rHA	rHA	NNP
cord-001835-0s7ok4uw	4686	21	)	)	-RRB-
cord-001835-0s7ok4uw	4686	22	assumed	assume	VBD
cord-001835-0s7ok4uw	4686	23	based	base	VBN
cord-001835-0s7ok4uw	4686	24	on	on	IN
cord-001835-0s7ok4uw	4686	25	the	the	DT
cord-001835-0s7ok4uw	4686	26	cDNA	cdna	NN
cord-001835-0s7ok4uw	4686	27	and	and	CC
cord-001835-0s7ok4uw	4686	28	allowed	allow	VBN
cord-001835-0s7ok4uw	4686	29	to	to	TO
cord-001835-0s7ok4uw	4686	30	establish	establish	VB
cord-001835-0s7ok4uw	4686	31	the	the	DT
cord-001835-0s7ok4uw	4686	32	location	location	NN
cord-001835-0s7ok4uw	4686	33	of	of	IN
cord-001835-0s7ok4uw	4686	34	a	a	DT
cord-001835-0s7ok4uw	4686	35	total	total	NN
cord-001835-0s7ok4uw	4686	36	of	of	IN
cord-001835-0s7ok4uw	4686	37	six	six	CD
cord-001835-0s7ok4uw	4686	38	disulfide	disulfide	NN
cord-001835-0s7ok4uw	4686	39	bridges	bridge	NNS
cord-001835-0s7ok4uw	4686	40	.	.	.
cord-001835-0s7ok4uw	4687	1	However	however	RB
cord-001835-0s7ok4uw	4687	2	,	,	,
cord-001835-0s7ok4uw	4687	3	during	during	IN
cord-001835-0s7ok4uw	4687	4	purification	purification	NN
cord-001835-0s7ok4uw	4687	5	and	and	CC
cord-001835-0s7ok4uw	4687	6	storage	storage	NN
cord-001835-0s7ok4uw	4687	7	of	of	IN
cord-001835-0s7ok4uw	4687	8	the	the	DT
cord-001835-0s7ok4uw	4687	9	rHA	rHA	NNS
cord-001835-0s7ok4uw	4687	10	,	,	,
cord-001835-0s7ok4uw	4687	11	apart	apart	RB
cord-001835-0s7ok4uw	4687	12	from	from	IN
cord-001835-0s7ok4uw	4687	13	desired	desire	VBN
cord-001835-0s7ok4uw	4687	14	higher	high	JJR
cord-001835-0s7ok4uw	4687	15	order	order	NN
cord-001835-0s7ok4uw	4687	16	rosette	rosette	NN
cord-001835-0s7ok4uw	4687	17	-	-	HYPH
cord-001835-0s7ok4uw	4687	18	like	like	JJ
cord-001835-0s7ok4uw	4687	19	structures	structure	NNS
cord-001835-0s7ok4uw	4687	20	of	of	IN
cord-001835-0s7ok4uw	4687	21	the	the	DT
cord-001835-0s7ok4uw	4687	22	protein	protein	NN
cord-001835-0s7ok4uw	4687	23	,	,	,
cord-001835-0s7ok4uw	4687	24	other	other	JJ
cord-001835-0s7ok4uw	4687	25	non	non	JJ
cord-001835-0s7ok4uw	4687	26	-	-	JJ
cord-001835-0s7ok4uw	4687	27	native	native	JJ
cord-001835-0s7ok4uw	4687	28	species	specie	NNS
cord-001835-0s7ok4uw	4687	29	resulting	result	VBG
cord-001835-0s7ok4uw	4687	30	from	from	IN
cord-001835-0s7ok4uw	4687	31	posttranslational	posttranslational	JJ
cord-001835-0s7ok4uw	4687	32	modifications	modification	NNS
cord-001835-0s7ok4uw	4687	33	,	,	,
cord-001835-0s7ok4uw	4687	34	misfolding	misfolde	VBG
cord-001835-0s7ok4uw	4687	35	,	,	,
cord-001835-0s7ok4uw	4687	36	aggregation	aggregation	NN
cord-001835-0s7ok4uw	4687	37	and	and	CC
cord-001835-0s7ok4uw	4687	38	degradation	degradation	NN
cord-001835-0s7ok4uw	4687	39	may	may	MD
cord-001835-0s7ok4uw	4687	40	occur	occur	VB
cord-001835-0s7ok4uw	4687	41	what	what	WP
cord-001835-0s7ok4uw	4687	42	results	result	NNS
cord-001835-0s7ok4uw	4687	43	in	in	IN
cord-001835-0s7ok4uw	4687	44	reduced	reduce	VBN
cord-001835-0s7ok4uw	4687	45	vaccine	vaccine	NN
cord-001835-0s7ok4uw	4687	46	potency	potency	NN
cord-001835-0s7ok4uw	4687	47	.	.	.
cord-001835-0s7ok4uw	4688	1	Here	here	RB
cord-001835-0s7ok4uw	4688	2	,	,	,
cord-001835-0s7ok4uw	4688	3	besides	besides	IN
cord-001835-0s7ok4uw	4688	4	the	the	DT
cord-001835-0s7ok4uw	4688	5	properly	properly	RB
cord-001835-0s7ok4uw	4688	6	folded	fold	VBN
cord-001835-0s7ok4uw	4688	7	monomers	monomer	NNS
cord-001835-0s7ok4uw	4688	8	,	,	,
cord-001835-0s7ok4uw	4688	9	we	-PRON-	PRP
cord-001835-0s7ok4uw	4688	10	indicate	indicate	VBP
cord-001835-0s7ok4uw	4688	11	non	non	JJ
cord-001835-0s7ok4uw	4688	12	-	-	JJ
cord-001835-0s7ok4uw	4688	13	native	native	JJ
cord-001835-0s7ok4uw	4688	14	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	4688	15	induced	induce	VBN
cord-001835-0s7ok4uw	4688	16	by	by	IN
cord-001835-0s7ok4uw	4688	17	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	4688	18	crosslinking	crosslinking	NN
cord-001835-0s7ok4uw	4688	19	.	.	.
cord-001835-0s7ok4uw	4689	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	4689	2	,	,	,
cord-001835-0s7ok4uw	4689	3	several	several	JJ
cord-001835-0s7ok4uw	4689	4	free	free	JJ
cord-001835-0s7ok4uw	4689	5	cysteine	cysteine	NN
cord-001835-0s7ok4uw	4689	6	residues	residue	NNS
cord-001835-0s7ok4uw	4689	7	and	and	CC
cord-001835-0s7ok4uw	4689	8	unexpected	unexpected	JJ
cord-001835-0s7ok4uw	4689	9	intrachain	intrachain	NN
cord-001835-0s7ok4uw	4689	10	S	S	NNP
cord-001835-0s7ok4uw	4689	11	-	-	HYPH
cord-001835-0s7ok4uw	4689	12	S	S	NNP
cord-001835-0s7ok4uw	4689	13	were	be	VBD
cord-001835-0s7ok4uw	4689	14	identified	identify	VBN
cord-001835-0s7ok4uw	4689	15	in	in	IN
cord-001835-0s7ok4uw	4689	16	rHA	rHA	NNP
cord-001835-0s7ok4uw	4689	17	tryptic	tryptic	NNP
cord-001835-0s7ok4uw	4689	18	peptide	peptide	NN
cord-001835-0s7ok4uw	4689	19	maps	map	NNS
cord-001835-0s7ok4uw	4689	20	.	.	.
cord-001835-0s7ok4uw	4690	1	Cys	Cys	NNP
cord-001835-0s7ok4uw	4690	2	43	43	CD
cord-001835-0s7ok4uw	4690	3	was	be	VBD
cord-001835-0s7ok4uw	4690	4	found	find	VBN
cord-001835-0s7ok4uw	4690	5	most	most	RBS
cord-001835-0s7ok4uw	4690	6	susceptible	susceptible	JJ
cord-001835-0s7ok4uw	4690	7	to	to	IN
cord-001835-0s7ok4uw	4690	8	formation	formation	NN
cord-001835-0s7ok4uw	4690	9	of	of	IN
cord-001835-0s7ok4uw	4690	10	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	4690	11	bridges	bridge	NNS
cord-001835-0s7ok4uw	4690	12	between	between	IN
cord-001835-0s7ok4uw	4690	13	the	the	DT
cord-001835-0s7ok4uw	4690	14	distinct	distinct	JJ
cord-001835-0s7ok4uw	4690	15	chains	chain	NNS
cord-001835-0s7ok4uw	4690	16	of	of	IN
cord-001835-0s7ok4uw	4690	17	rHA	rHA	NNS
cord-001835-0s7ok4uw	4690	18	.	.	.
cord-001835-0s7ok4uw	4691	1	The	the	DT
cord-001835-0s7ok4uw	4691	2	above	above	JJ
cord-001835-0s7ok4uw	4691	3	findings	finding	NNS
cord-001835-0s7ok4uw	4691	4	allow	allow	VBP
cord-001835-0s7ok4uw	4691	5	to	to	TO
cord-001835-0s7ok4uw	4691	6	assume	assume	VB
cord-001835-0s7ok4uw	4691	7	that	that	IN
cord-001835-0s7ok4uw	4691	8	not	not	RB
cord-001835-0s7ok4uw	4691	9	all	all	DT
cord-001835-0s7ok4uw	4691	10	rHA	rha	NN
cord-001835-0s7ok4uw	4691	11	particles	particle	NNS
cord-001835-0s7ok4uw	4691	12	fold	fold	VBP
cord-001835-0s7ok4uw	4691	13	to	to	TO
cord-001835-0s7ok4uw	4691	14	form	form	VB
cord-001835-0s7ok4uw	4691	15	the	the	DT
cord-001835-0s7ok4uw	4691	16	native	native	JJ
cord-001835-0s7ok4uw	4691	17	structure	structure	NN
cord-001835-0s7ok4uw	4691	18	.	.	.
cord-001835-0s7ok4uw	4692	1	Reduced	reduce	VBN
cord-001835-0s7ok4uw	4692	2	Cys	Cys	NNP
cord-001835-0s7ok4uw	4692	3	residues	residue	NNS
cord-001835-0s7ok4uw	4692	4	exhibit	exhibit	VBP
cord-001835-0s7ok4uw	4692	5	tendency	tendency	NN
cord-001835-0s7ok4uw	4692	6	to	to	TO
cord-001835-0s7ok4uw	4692	7	undergo	undergo	VB
cord-001835-0s7ok4uw	4692	8	oxidation	oxidation	NN
cord-001835-0s7ok4uw	4692	9	and	and	CC
cord-001835-0s7ok4uw	4692	10	uncon-	uncon-	JJ
cord-001835-0s7ok4uw	4692	11	New	new	JJ
cord-001835-0s7ok4uw	4692	12	strategies	strategy	NNS
cord-001835-0s7ok4uw	4692	13	and	and	CC
cord-001835-0s7ok4uw	4692	14	approaches	approach	VBZ
cord-001835-0s7ok4uw	4692	15	to	to	TO
cord-001835-0s7ok4uw	4692	16	understand	understand	VB
cord-001835-0s7ok4uw	4692	17	how	how	WRB
cord-001835-0s7ok4uw	4692	18	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4692	19	recognize	recognize	VBP
cord-001835-0s7ok4uw	4692	20	and	and	CC
cord-001835-0s7ok4uw	4692	21	neutralize	neutralize	VB
cord-001835-0s7ok4uw	4692	22	snake	snake	NN
cord-001835-0s7ok4uw	4692	23	toxins	toxin	NNS
cord-001835-0s7ok4uw	4692	24	represent	represent	VBP
cord-001835-0s7ok4uw	4692	25	a	a	DT
cord-001835-0s7ok4uw	4692	26	challenge	challenge	NN
cord-001835-0s7ok4uw	4692	27	to	to	TO
cord-001835-0s7ok4uw	4692	28	improve	improve	VB
cord-001835-0s7ok4uw	4692	29	the	the	DT
cord-001835-0s7ok4uw	4692	30	antivenoms	antivenom	NNS
cord-001835-0s7ok4uw	4692	31	.	.	.
cord-001835-0s7ok4uw	4693	1	The	the	DT
cord-001835-0s7ok4uw	4693	2	neurotoxic	neurotoxic	JJ
cord-001835-0s7ok4uw	4693	3	activity	activity	NN
cord-001835-0s7ok4uw	4693	4	of	of	IN
cord-001835-0s7ok4uw	4693	5	Micrurus	Micrurus	NNP
cord-001835-0s7ok4uw	4693	6	venom	venom	NN
cord-001835-0s7ok4uw	4693	7	is	be	VBZ
cord-001835-0s7ok4uw	4693	8	carried	carry	VBN
cord-001835-0s7ok4uw	4693	9	majority	majority	NN
cord-001835-0s7ok4uw	4693	10	by	by	IN
cord-001835-0s7ok4uw	4693	11	two	two	CD
cord-001835-0s7ok4uw	4693	12	distinct	distinct	JJ
cord-001835-0s7ok4uw	4693	13	proteins	protein	NNS
cord-001835-0s7ok4uw	4693	14	families	family	NNS
cord-001835-0s7ok4uw	4693	15	,	,	,
cord-001835-0s7ok4uw	4693	16	3FTx	3ftx	CD
cord-001835-0s7ok4uw	4693	17	and	and	CC
cord-001835-0s7ok4uw	4693	18	PLA2	PLA2	NNP
cord-001835-0s7ok4uw	4693	19	.	.	.
cord-001835-0s7ok4uw	4694	1	The	the	DT
cord-001835-0s7ok4uw	4694	2	conserved	conserved	JJ
cord-001835-0s7ok4uw	4694	3	structural	structural	JJ
cord-001835-0s7ok4uw	4694	4	folding	folding	NN
cord-001835-0s7ok4uw	4694	5	of	of	IN
cord-001835-0s7ok4uw	4694	6	these	these	DT
cord-001835-0s7ok4uw	4694	7	toxins	toxin	NNS
cord-001835-0s7ok4uw	4694	8	can	can	MD
cord-001835-0s7ok4uw	4694	9	be	be	VB
cord-001835-0s7ok4uw	4694	10	appreciated	appreciate	VBN
cord-001835-0s7ok4uw	4694	11	as	as	IN
cord-001835-0s7ok4uw	4694	12	model	model	NN
cord-001835-0s7ok4uw	4694	13	to	to	TO
cord-001835-0s7ok4uw	4694	14	generate	generate	VB
cord-001835-0s7ok4uw	4694	15	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4694	16	against	against	IN
cord-001835-0s7ok4uw	4694	17	them	-PRON-	PRP
cord-001835-0s7ok4uw	4694	18	.	.	.
cord-001835-0s7ok4uw	4695	1	In	in	IN
cord-001835-0s7ok4uw	4695	2	this	this	DT
cord-001835-0s7ok4uw	4695	3	regard	regard	NN
cord-001835-0s7ok4uw	4695	4	,	,	,
cord-001835-0s7ok4uw	4695	5	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	4695	6	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4695	7	(	(	-LRB-
cord-001835-0s7ok4uw	4695	8	mAbs	mAbs	NNP
cord-001835-0s7ok4uw	4695	9	)	)	-RRB-
cord-001835-0s7ok4uw	4695	10	can	can	MD
cord-001835-0s7ok4uw	4695	11	be	be	VB
cord-001835-0s7ok4uw	4695	12	used	use	VBN
cord-001835-0s7ok4uw	4695	13	as	as	IN
cord-001835-0s7ok4uw	4695	14	tool	tool	NN
cord-001835-0s7ok4uw	4695	15	to	to	TO
cord-001835-0s7ok4uw	4695	16	find	find	VB
cord-001835-0s7ok4uw	4695	17	hot	hot	JJ
cord-001835-0s7ok4uw	4695	18	spots	spot	NNS
cord-001835-0s7ok4uw	4695	19	for	for	IN
cord-001835-0s7ok4uw	4695	20	inhibit	inhibit	NN
cord-001835-0s7ok4uw	4695	21	the	the	DT
cord-001835-0s7ok4uw	4695	22	toxins	toxin	NNS
cord-001835-0s7ok4uw	4695	23	and	and	CC
cord-001835-0s7ok4uw	4695	24	represent	represent	VB
cord-001835-0s7ok4uw	4695	25	the	the	DT
cord-001835-0s7ok4uw	4695	26	first	first	JJ
cord-001835-0s7ok4uw	4695	27	step	step	NN
cord-001835-0s7ok4uw	4695	28	in	in	IN
cord-001835-0s7ok4uw	4695	29	order	order	NN
cord-001835-0s7ok4uw	4695	30	to	to	TO
cord-001835-0s7ok4uw	4695	31	develop	develop	VB
cord-001835-0s7ok4uw	4695	32	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	4695	33	neutralizing	neutralize	VBG
cord-001835-0s7ok4uw	4695	34	molecules	molecule	NNS
cord-001835-0s7ok4uw	4695	35	.	.	.
cord-001835-0s7ok4uw	4696	1	In	in	IN
cord-001835-0s7ok4uw	4696	2	this	this	DT
cord-001835-0s7ok4uw	4696	3	work	work	NN
cord-001835-0s7ok4uw	4696	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4696	5	goals	goal	NNS
cord-001835-0s7ok4uw	4696	6	were	be	VBD
cord-001835-0s7ok4uw	4696	7	analyse	analyse	VB
cord-001835-0s7ok4uw	4696	8	a	a	DT
cord-001835-0s7ok4uw	4696	9	set	set	NN
cord-001835-0s7ok4uw	4696	10	of	of	IN
cord-001835-0s7ok4uw	4696	11	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	4696	12	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4696	13	against	against	IN
cord-001835-0s7ok4uw	4696	14	the	the	DT
cord-001835-0s7ok4uw	4696	15	most	most	RBS
cord-001835-0s7ok4uw	4696	16	toxic	toxic	JJ
cord-001835-0s7ok4uw	4696	17	components	component	NNS
cord-001835-0s7ok4uw	4696	18	of	of	IN
cord-001835-0s7ok4uw	4696	19	M.	M.	NNP
cord-001835-0s7ok4uw	4696	20	altirostris	altirostris	JJ
cord-001835-0s7ok4uw	4696	21	venom	venom	NN
cord-001835-0s7ok4uw	4696	22	by	by	IN
cord-001835-0s7ok4uw	4696	23	proteomics	proteomic	NNS
cord-001835-0s7ok4uw	4696	24	approaches	approach	NNS
cord-001835-0s7ok4uw	4696	25	.	.	.
cord-001835-0s7ok4uw	4697	1	The	the	DT
cord-001835-0s7ok4uw	4697	2	venom	venom	NN
cord-001835-0s7ok4uw	4697	3	was	be	VBD
cord-001835-0s7ok4uw	4697	4	fractionated	fractionate	VBN
cord-001835-0s7ok4uw	4697	5	;	;	:
cord-001835-0s7ok4uw	4697	6	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4697	7	major	major	JJ
cord-001835-0s7ok4uw	4697	8	toxic	toxic	JJ
cord-001835-0s7ok4uw	4697	9	proteins	protein	NNS
cord-001835-0s7ok4uw	4697	10	identified	identify	VBN
cord-001835-0s7ok4uw	4697	11	by	by	IN
cord-001835-0s7ok4uw	4697	12	in	in	IN
cord-001835-0s7ok4uw	4697	13	vivo	vivo	NN
cord-001835-0s7ok4uw	4697	14	tests	test	NNS
cord-001835-0s7ok4uw	4697	15	based	base	VBN
cord-001835-0s7ok4uw	4697	16	on	on	IN
cord-001835-0s7ok4uw	4697	17	murine	murine	JJ
cord-001835-0s7ok4uw	4697	18	lethal	lethal	JJ
cord-001835-0s7ok4uw	4697	19	toxicity	toxicity	NN
cord-001835-0s7ok4uw	4697	20	analyses	analysis	NNS
cord-001835-0s7ok4uw	4697	21	(	(	-LRB-
cord-001835-0s7ok4uw	4697	22	approved	approve	VBN
cord-001835-0s7ok4uw	4697	23	by	by	IN
cord-001835-0s7ok4uw	4697	24	the	the	DT
cord-001835-0s7ok4uw	4697	25	Ethical	Ethical	NNP
cord-001835-0s7ok4uw	4697	26	Committee	Committee	NNP
cord-001835-0s7ok4uw	4697	27	for	for	IN
cord-001835-0s7ok4uw	4697	28	Animal	Animal	NNP
cord-001835-0s7ok4uw	4697	29	Experimentation	Experimentation	NNP
cord-001835-0s7ok4uw	4697	30	from	from	IN
cord-001835-0s7ok4uw	4697	31	Center	Center	NNP
cord-001835-0s7ok4uw	4697	32	of	of	IN
cord-001835-0s7ok4uw	4697	33	Health	Health	NNP
cord-001835-0s7ok4uw	4697	34	and	and	CC
cord-001835-0s7ok4uw	4697	35	Science	Science	NNP
cord-001835-0s7ok4uw	4697	36	of	of	IN
cord-001835-0s7ok4uw	4697	37	the	the	DT
cord-001835-0s7ok4uw	4697	38	Federal	Federal	NNP
cord-001835-0s7ok4uw	4697	39	University	University	NNP
cord-001835-0s7ok4uw	4697	40	of	of	IN
cord-001835-0s7ok4uw	4697	41	Rio	Rio	NNP
cord-001835-0s7ok4uw	4697	42	de	de	NNP
cord-001835-0s7ok4uw	4697	43	Janeiro	Janeiro	NNP
cord-001835-0s7ok4uw	4698	1	-no	-no	:
cord-001835-0s7ok4uw	4698	2	.	.	.
cord-001835-0s7ok4uw	4699	1	01200.001568/2013	01200.001568/2013	LS
cord-001835-0s7ok4uw	4699	2	-	-	SYM
cord-001835-0s7ok4uw	4699	3	87	87	CD
cord-001835-0s7ok4uw	4699	4	)	)	-RRB-
cord-001835-0s7ok4uw	4699	5	.	.	.
cord-001835-0s7ok4uw	4700	1	The	the	DT
cord-001835-0s7ok4uw	4700	2	toxic	toxic	JJ
cord-001835-0s7ok4uw	4700	3	components	component	NNS
cord-001835-0s7ok4uw	4700	4	were	be	VBD
cord-001835-0s7ok4uw	4700	5	used	use	VBN
cord-001835-0s7ok4uw	4700	6	to	to	TO
cord-001835-0s7ok4uw	4700	7	generate	generate	VB
cord-001835-0s7ok4uw	4700	8	a	a	DT
cord-001835-0s7ok4uw	4700	9	panel	panel	NN
cord-001835-0s7ok4uw	4700	10	of	of	IN
cord-001835-0s7ok4uw	4700	11	five	five	CD
cord-001835-0s7ok4uw	4700	12	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	4700	13	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4700	14	.	.	.
cord-001835-0s7ok4uw	4701	1	ELISA	ELISA	NNP
cord-001835-0s7ok4uw	4701	2	and	and	CC
cord-001835-0s7ok4uw	4701	3	antivenomics	antivenomics	NNP
cord-001835-0s7ok4uw	4701	4	results	result	NNS
cord-001835-0s7ok4uw	4701	5	allowed	allow	VBD
cord-001835-0s7ok4uw	4701	6	us	-PRON-	PRP
cord-001835-0s7ok4uw	4701	7	identify	identify	VB
cord-001835-0s7ok4uw	4701	8	the	the	DT
cord-001835-0s7ok4uw	4701	9	specificity	specificity	NN
cord-001835-0s7ok4uw	4701	10	of	of	IN
cord-001835-0s7ok4uw	4701	11	all	all	DT
cord-001835-0s7ok4uw	4701	12	mAb	mAb	NNS
cord-001835-0s7ok4uw	4701	13	and	and	CC
cord-001835-0s7ok4uw	4701	14	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4701	15	neutralizing	neutralize	VBG
cord-001835-0s7ok4uw	4701	16	efficacy	efficacy	NN
cord-001835-0s7ok4uw	4701	17	was	be	VBD
cord-001835-0s7ok4uw	4701	18	measured	measure	VBN
cord-001835-0s7ok4uw	4701	19	by	by	IN
cord-001835-0s7ok4uw	4701	20	in	in	FW
cord-001835-0s7ok4uw	4701	21	vitro	vitro	FW
cord-001835-0s7ok4uw	4701	22	tests	test	NNS
cord-001835-0s7ok4uw	4701	23	.	.	.
cord-001835-0s7ok4uw	4702	1	Three	three	CD
cord-001835-0s7ok4uw	4702	2	mAbs	mAbs	NNP
cord-001835-0s7ok4uw	4702	3	showed	show	VBD
cord-001835-0s7ok4uw	4702	4	reactivity	reactivity	NN
cord-001835-0s7ok4uw	4702	5	towards	towards	IN
cord-001835-0s7ok4uw	4702	6	3FTx	3ftx	CD
cord-001835-0s7ok4uw	4702	7	and	and	CC
cord-001835-0s7ok4uw	4702	8	two	two	CD
cord-001835-0s7ok4uw	4702	9	against	against	IN
cord-001835-0s7ok4uw	4702	10	PLA2	PLA2	NNP
cord-001835-0s7ok4uw	4702	11	.	.	.
cord-001835-0s7ok4uw	4703	1	All	all	DT
cord-001835-0s7ok4uw	4703	2	Monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	4703	3	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4703	4	against	against	IN
cord-001835-0s7ok4uw	4703	5	3FTx	3ftx	CD
cord-001835-0s7ok4uw	4703	6	lack	lack	VBP
cord-001835-0s7ok4uw	4703	7	a	a	DT
cord-001835-0s7ok4uw	4703	8	broad	broad	JJ
cord-001835-0s7ok4uw	4703	9	recognition	recognition	NN
cord-001835-0s7ok4uw	4703	10	.	.	.
cord-001835-0s7ok4uw	4704	1	However	however	RB
cord-001835-0s7ok4uw	4704	2	,	,	,
cord-001835-0s7ok4uw	4704	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4704	4	identified	identify	VBD
cord-001835-0s7ok4uw	4704	5	a	a	DT
cord-001835-0s7ok4uw	4704	6	pair	pair	NN
cord-001835-0s7ok4uw	4704	7	of	of	IN
cord-001835-0s7ok4uw	4704	8	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	4704	9	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4704	10	able	able	JJ
cord-001835-0s7ok4uw	4704	11	to	to	TO
cord-001835-0s7ok4uw	4704	12	recognize	recognize	VB
cord-001835-0s7ok4uw	4704	13	all	all	DT
cord-001835-0s7ok4uw	4704	14	PLA2	PLA2	NNP
cord-001835-0s7ok4uw	4704	15	molecules	molecule	NNS
cord-001835-0s7ok4uw	4704	16	of	of	IN
cord-001835-0s7ok4uw	4704	17	M.	M.	NNP
cord-001835-0s7ok4uw	4704	18	altirostris	altirostris	JJ
cord-001835-0s7ok4uw	4704	19	venom	venom	NN
cord-001835-0s7ok4uw	4704	20	and	and	CC
cord-001835-0s7ok4uw	4704	21	showed	show	VBD
cord-001835-0s7ok4uw	4704	22	a	a	DT
cord-001835-0s7ok4uw	4704	23	synergism	synergism	NN
cord-001835-0s7ok4uw	4704	24	to	to	TO
cord-001835-0s7ok4uw	4704	25	inhibit	inhibit	VB
cord-001835-0s7ok4uw	4704	26	the	the	DT
cord-001835-0s7ok4uw	4704	27	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	4704	28	activity	activity	NN
cord-001835-0s7ok4uw	4704	29	of	of	IN
cord-001835-0s7ok4uw	4704	30	them	-PRON-	PRP
cord-001835-0s7ok4uw	4704	31	.	.	.
cord-001835-0s7ok4uw	4705	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	4705	2	,	,	,
cord-001835-0s7ok4uw	4705	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4705	4	challenge	challenge	VBP
cord-001835-0s7ok4uw	4705	5	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	4705	6	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4705	7	against	against	IN
cord-001835-0s7ok4uw	4705	8	to	to	IN
cord-001835-0s7ok4uw	4705	9	Micrurus	Micrurus	NNP
cord-001835-0s7ok4uw	4705	10	venom	venom	NN
cord-001835-0s7ok4uw	4705	11	for	for	IN
cord-001835-0s7ok4uw	4705	12	inhibit	inhibit	NN
cord-001835-0s7ok4uw	4705	13	the	the	DT
cord-001835-0s7ok4uw	4705	14	PLA2	PLA2	NNP
cord-001835-0s7ok4uw	4705	15	activity	activity	NN
cord-001835-0s7ok4uw	4705	16	of	of	IN
cord-001835-0s7ok4uw	4705	17	Naja	Naja	NNP
cord-001835-0s7ok4uw	4705	18	Naja	Naja	NNP
cord-001835-0s7ok4uw	4705	19	,	,	,
cord-001835-0s7ok4uw	4705	20	specie	specie	FW
cord-001835-0s7ok4uw	4705	21	taxonomically	taxonomically	RB
cord-001835-0s7ok4uw	4705	22	out	out	IN
cord-001835-0s7ok4uw	4705	23	of	of	IN
cord-001835-0s7ok4uw	4705	24	Micrurus	Micrurus	NNP
cord-001835-0s7ok4uw	4705	25	cluster	cluster	NN
cord-001835-0s7ok4uw	4705	26	.	.	.
cord-001835-0s7ok4uw	4706	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4706	2	results	result	NNS
cord-001835-0s7ok4uw	4706	3	showed	show	VBD
cord-001835-0s7ok4uw	4706	4	that	that	IN
cord-001835-0s7ok4uw	4706	5	PLA2	PLA2	NNP
cord-001835-0s7ok4uw	4706	6	of	of	IN
cord-001835-0s7ok4uw	4706	7	M.	M.	NNP
cord-001835-0s7ok4uw	4706	8	altirostris	altirostris	NNP
cord-001835-0s7ok4uw	4706	9	venom	venom	NN
cord-001835-0s7ok4uw	4706	10	share	share	VBP
cord-001835-0s7ok4uw	4706	11	a	a	DT
cord-001835-0s7ok4uw	4706	12	pair	pair	NN
cord-001835-0s7ok4uw	4706	13	of	of	IN
cord-001835-0s7ok4uw	4706	14	conserved	conserved	JJ
cord-001835-0s7ok4uw	4706	15	antigenic	antigenic	JJ
cord-001835-0s7ok4uw	4706	16	regions	region	NNS
cord-001835-0s7ok4uw	4706	17	and	and	CC
cord-001835-0s7ok4uw	4706	18	draw	draw	VB
cord-001835-0s7ok4uw	4706	19	attention	attention	NN
cord-001835-0s7ok4uw	4706	20	to	to	TO
cord-001835-0s7ok4uw	4706	21	use	use	VB
cord-001835-0s7ok4uw	4706	22	these	these	DT
cord-001835-0s7ok4uw	4706	23	epitopes	epitope	NNS
cord-001835-0s7ok4uw	4706	24	to	to	IN
cord-001835-0s7ok4uw	4706	25	miming	mime	VBG
cord-001835-0s7ok4uw	4706	26	antigen	antigen	NN
cord-001835-0s7ok4uw	4706	27	to	to	TO
cord-001835-0s7ok4uw	4706	28	generate	generate	VB
cord-001835-0s7ok4uw	4706	29	antibodies	antibody	NNS
cord-001835-0s7ok4uw	4706	30	for	for	IN
cord-001835-0s7ok4uw	4706	31	antivenom	antivenom	NN
cord-001835-0s7ok4uw	4706	32	production	production	NN
cord-001835-0s7ok4uw	4706	33	.	.	.
cord-001835-0s7ok4uw	4707	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	4707	2	,	,	,
cord-001835-0s7ok4uw	4707	3	face	face	VB
cord-001835-0s7ok4uw	4707	4	to	to	IN
cord-001835-0s7ok4uw	4707	5	the	the	DT
cord-001835-0s7ok4uw	4707	6	cross	cross	NN
cord-001835-0s7ok4uw	4707	7	reactivity	reactivity	NN
cord-001835-0s7ok4uw	4707	8	and	and	CC
cord-001835-0s7ok4uw	4707	9	the	the	DT
cord-001835-0s7ok4uw	4707	10	PLA2	PLA2	NNP
cord-001835-0s7ok4uw	4707	11	activity	activity	NN
cord-001835-0s7ok4uw	4707	12	inhibition	inhibition	NN
cord-001835-0s7ok4uw	4707	13	capability	capability	NN
cord-001835-0s7ok4uw	4707	14	by	by	IN
cord-001835-0s7ok4uw	4707	15	mAbs	mAbs	NNP
cord-001835-0s7ok4uw	4707	16	towards	towards	IN
cord-001835-0s7ok4uw	4707	17	the	the	DT
cord-001835-0s7ok4uw	4707	18	Naja	Naja	NNP
cord-001835-0s7ok4uw	4707	19	Naja	Naja	NNP
cord-001835-0s7ok4uw	4707	20	venom	venom	NN
cord-001835-0s7ok4uw	4707	21	,	,	,
cord-001835-0s7ok4uw	4707	22	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4707	23	results	result	NNS
cord-001835-0s7ok4uw	4707	24	highlight	highlight	VBP
cord-001835-0s7ok4uw	4707	25	the	the	DT
cord-001835-0s7ok4uw	4707	26	conservation	conservation	NN
cord-001835-0s7ok4uw	4707	27	of	of	IN
cord-001835-0s7ok4uw	4707	28	neutralizing	neutralize	VBG
cord-001835-0s7ok4uw	4707	29	epitopes	epitope	NNS
cord-001835-0s7ok4uw	4707	30	across	across	IN
cord-001835-0s7ok4uw	4707	31	the	the	DT
cord-001835-0s7ok4uw	4707	32	Elapidae	Elapidae	NNP
cord-001835-0s7ok4uw	4707	33	family	family	NN
cord-001835-0s7ok4uw	4707	34	.	.	.
cord-001835-0s7ok4uw	4708	1	Protein	protein	NN
cord-001835-0s7ok4uw	4708	2	-	-	HYPH
cord-001835-0s7ok4uw	4708	3	protein	protein	NN
cord-001835-0s7ok4uw	4708	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	4708	5	are	be	VBP
cord-001835-0s7ok4uw	4708	6	known	know	VBN
cord-001835-0s7ok4uw	4708	7	to	to	TO
cord-001835-0s7ok4uw	4708	8	play	play	VB
cord-001835-0s7ok4uw	4708	9	key	key	JJ
cord-001835-0s7ok4uw	4708	10	roles	role	NNS
cord-001835-0s7ok4uw	4708	11	in	in	IN
cord-001835-0s7ok4uw	4708	12	the	the	DT
cord-001835-0s7ok4uw	4708	13	most	most	RBS
cord-001835-0s7ok4uw	4708	14	important	important	JJ
cord-001835-0s7ok4uw	4708	15	cellular	cellular	JJ
cord-001835-0s7ok4uw	4708	16	and	and	CC
cord-001835-0s7ok4uw	4708	17	biological	biological	JJ
cord-001835-0s7ok4uw	4708	18	processes	process	NNS
cord-001835-0s7ok4uw	4708	19	such	such	JJ
cord-001835-0s7ok4uw	4708	20	as	as	IN
cord-001835-0s7ok4uw	4708	21	signaling	signal	VBG
cord-001835-0s7ok4uw	4708	22	,	,	,
cord-001835-0s7ok4uw	4708	23	metabolism	metabolism	NN
cord-001835-0s7ok4uw	4708	24	,	,	,
cord-001835-0s7ok4uw	4708	25	and	and	CC
cord-001835-0s7ok4uw	4708	26	trafficking	trafficking	NN
cord-001835-0s7ok4uw	4708	27	.	.	.
cord-001835-0s7ok4uw	4709	1	One	one	CD
cord-001835-0s7ok4uw	4709	2	major	major	JJ
cord-001835-0s7ok4uw	4709	3	goal	goal	NN
cord-001835-0s7ok4uw	4709	4	of	of	IN
cord-001835-0s7ok4uw	4709	5	structural	structural	JJ
cord-001835-0s7ok4uw	4709	6	biology	biology	NN
cord-001835-0s7ok4uw	4709	7	is	be	VBZ
cord-001835-0s7ok4uw	4709	8	the	the	DT
cord-001835-0s7ok4uw	4709	9	structural	structural	JJ
cord-001835-0s7ok4uw	4709	10	characterization	characterization	NN
cord-001835-0s7ok4uw	4709	11	of	of	IN
cord-001835-0s7ok4uw	4709	12	all	all	DT
cord-001835-0s7ok4uw	4709	13	protein	protein	NN
cord-001835-0s7ok4uw	4709	14	complexes	complex	NNS
cord-001835-0s7ok4uw	4709	15	in	in	IN
cord-001835-0s7ok4uw	4709	16	human	human	JJ
cord-001835-0s7ok4uw	4709	17	and	and	CC
cord-001835-0s7ok4uw	4709	18	other	other	JJ
cord-001835-0s7ok4uw	4709	19	organisms	organism	NNS
cord-001835-0s7ok4uw	4709	20	.	.	.
cord-001835-0s7ok4uw	4710	1	These	these	DT
cord-001835-0s7ok4uw	4710	2	efforts	effort	NNS
cord-001835-0s7ok4uw	4710	3	can	can	MD
cord-001835-0s7ok4uw	4710	4	be	be	VB
cord-001835-0s7ok4uw	4710	5	complemented	complement	VBN
cord-001835-0s7ok4uw	4710	6	by	by	IN
cord-001835-0s7ok4uw	4710	7	computational	computational	JJ
cord-001835-0s7ok4uw	4710	8	approaches	approach	NNS
cord-001835-0s7ok4uw	4710	9	.	.	.
cord-001835-0s7ok4uw	4711	1	In	in	IN
cord-001835-0s7ok4uw	4711	2	this	this	DT
cord-001835-0s7ok4uw	4711	3	context	context	NN
cord-001835-0s7ok4uw	4711	4	,	,	,
cord-001835-0s7ok4uw	4711	5	computational	computational	JJ
cord-001835-0s7ok4uw	4711	6	docking	docking	NN
cord-001835-0s7ok4uw	4711	7	attempts	attempt	NNS
cord-001835-0s7ok4uw	4711	8	to	to	TO
cord-001835-0s7ok4uw	4711	9	predict	predict	VB
cord-001835-0s7ok4uw	4711	10	the	the	DT
cord-001835-0s7ok4uw	4711	11	structure	structure	NN
cord-001835-0s7ok4uw	4711	12	of	of	IN
cord-001835-0s7ok4uw	4711	13	complexes	complex	NNS
cord-001835-0s7ok4uw	4711	14	from	from	IN
cord-001835-0s7ok4uw	4711	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4711	16	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	4711	17	constituents	constituent	NNS
cord-001835-0s7ok4uw	4711	18	.	.	.
cord-001835-0s7ok4uw	4712	1	The	the	DT
cord-001835-0s7ok4uw	4712	2	docking	docking	NN
cord-001835-0s7ok4uw	4712	3	problem	problem	NN
cord-001835-0s7ok4uw	4712	4	presents	present	VBZ
cord-001835-0s7ok4uw	4712	5	two	two	CD
cord-001835-0s7ok4uw	4712	6	main	main	JJ
cord-001835-0s7ok4uw	4712	7	challenges	challenge	NNS
cord-001835-0s7ok4uw	4712	8	:	:	:
cord-001835-0s7ok4uw	4712	9	the	the	DT
cord-001835-0s7ok4uw	4712	10	generation	generation	NN
cord-001835-0s7ok4uw	4712	11	of	of	IN
cord-001835-0s7ok4uw	4712	12	structural	structural	JJ
cord-001835-0s7ok4uw	4712	13	poses	pose	NNS
cord-001835-0s7ok4uw	4712	14	or	or	CC
cord-001835-0s7ok4uw	4712	15	sampling	sampling	NN
cord-001835-0s7ok4uw	4712	16	,	,	,
cord-001835-0s7ok4uw	4712	17	and	and	CC
cord-001835-0s7ok4uw	4712	18	the	the	DT
cord-001835-0s7ok4uw	4712	19	identification	identification	NN
cord-001835-0s7ok4uw	4712	20	of	of	IN
cord-001835-0s7ok4uw	4712	21	the	the	DT
cord-001835-0s7ok4uw	4712	22	correct	correct	JJ
cord-001835-0s7ok4uw	4712	23	structures	structure	NNS
cord-001835-0s7ok4uw	4712	24	with	with	IN
cord-001835-0s7ok4uw	4712	25	a	a	DT
cord-001835-0s7ok4uw	4712	26	scoring	scoring	NN
cord-001835-0s7ok4uw	4712	27	function	function	NN
cord-001835-0s7ok4uw	4712	28	(	(	-LRB-
cord-001835-0s7ok4uw	4712	29	SF	SF	NNP
cord-001835-0s7ok4uw	4712	30	)	)	-RRB-
cord-001835-0s7ok4uw	4712	31	.	.	.
cord-001835-0s7ok4uw	4713	1	Docking	docking	NN
cord-001835-0s7ok4uw	4713	2	methods	method	NNS
cord-001835-0s7ok4uw	4713	3	can	can	MD
cord-001835-0s7ok4uw	4713	4	be	be	VB
cord-001835-0s7ok4uw	4713	5	successful	successful	JJ
cord-001835-0s7ok4uw	4713	6	if	if	IN
cord-001835-0s7ok4uw	4713	7	the	the	DT
cord-001835-0s7ok4uw	4713	8	interacting	interact	VBG
cord-001835-0s7ok4uw	4713	9	partners	partner	NNS
cord-001835-0s7ok4uw	4713	10	undergo	undergo	VBP
cord-001835-0s7ok4uw	4713	11	small	small	JJ
cord-001835-0s7ok4uw	4713	12	conformational	conformational	JJ
cord-001835-0s7ok4uw	4713	13	changes	change	NNS
cord-001835-0s7ok4uw	4713	14	.	.	.
cord-001835-0s7ok4uw	4714	1	However	however	RB
cord-001835-0s7ok4uw	4714	2	,	,	,
cord-001835-0s7ok4uw	4714	3	in	in	IN
cord-001835-0s7ok4uw	4714	4	a	a	DT
cord-001835-0s7ok4uw	4714	5	general	general	JJ
cord-001835-0s7ok4uw	4714	6	situation	situation	NN
cord-001835-0s7ok4uw	4714	7	,	,	,
cord-001835-0s7ok4uw	4714	8	these	these	DT
cord-001835-0s7ok4uw	4714	9	algorithms	algorithm	NNS
cord-001835-0s7ok4uw	4714	10	generate	generate	VBP
cord-001835-0s7ok4uw	4714	11	a	a	DT
cord-001835-0s7ok4uw	4714	12	large	large	JJ
cord-001835-0s7ok4uw	4714	13	number	number	NN
cord-001835-0s7ok4uw	4714	14	of	of	IN
cord-001835-0s7ok4uw	4714	15	incorrect	incorrect	JJ
cord-001835-0s7ok4uw	4714	16	predictions	prediction	NNS
cord-001835-0s7ok4uw	4714	17	,	,	,
cord-001835-0s7ok4uw	4714	18	and	and	CC
cord-001835-0s7ok4uw	4714	19	therefore	therefore	RB
cord-001835-0s7ok4uw	4714	20	the	the	DT
cord-001835-0s7ok4uw	4714	21	predictive	predictive	JJ
cord-001835-0s7ok4uw	4714	22	success	success	NN
cord-001835-0s7ok4uw	4714	23	strongly	strongly	RB
cord-001835-0s7ok4uw	4714	24	depends	depend	VBZ
cord-001835-0s7ok4uw	4714	25	on	on	IN
cord-001835-0s7ok4uw	4714	26	the	the	DT
cord-001835-0s7ok4uw	4714	27	accuracy	accuracy	NN
cord-001835-0s7ok4uw	4714	28	of	of	IN
cord-001835-0s7ok4uw	4714	29	the	the	DT
cord-001835-0s7ok4uw	4714	30	SF	SF	NNP
cord-001835-0s7ok4uw	4714	31	used	use	VBD
cord-001835-0s7ok4uw	4714	32	to	to	TO
cord-001835-0s7ok4uw	4714	33	evaluate	evaluate	VB
cord-001835-0s7ok4uw	4714	34	the	the	DT
cord-001835-0s7ok4uw	4714	35	docked	dock	VBN
cord-001835-0s7ok4uw	4714	36	conformations	conformation	NNS
cord-001835-0s7ok4uw	4714	37	.	.	.
cord-001835-0s7ok4uw	4715	1	A	a	DT
cord-001835-0s7ok4uw	4715	2	variety	variety	NN
cord-001835-0s7ok4uw	4715	3	of	of	IN
cord-001835-0s7ok4uw	4715	4	strategies	strategy	NNS
cord-001835-0s7ok4uw	4715	5	have	have	VBP
cord-001835-0s7ok4uw	4715	6	been	be	VBN
cord-001835-0s7ok4uw	4715	7	developed	develop	VBN
cord-001835-0s7ok4uw	4715	8	to	to	TO
cord-001835-0s7ok4uw	4715	9	score	score	VB
cord-001835-0s7ok4uw	4715	10	putative	putative	JJ
cord-001835-0s7ok4uw	4715	11	protein	protein	NN
cord-001835-0s7ok4uw	4715	12	-	-	HYPH
cord-001835-0s7ok4uw	4715	13	protein	protein	NN
cord-001835-0s7ok4uw	4715	14	docked	dock	VBN
cord-001835-0s7ok4uw	4715	15	complexes	complex	NNS
cord-001835-0s7ok4uw	4715	16	.	.	.
cord-001835-0s7ok4uw	4716	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	4716	2	are	be	VBP
cord-001835-0s7ok4uw	4716	3	usually	usually	RB
cord-001835-0s7ok4uw	4716	4	based	base	VBN
cord-001835-0s7ok4uw	4716	5	on	on	IN
cord-001835-0s7ok4uw	4716	6	atomic	atomic	JJ
cord-001835-0s7ok4uw	4716	7	level	level	NN
cord-001835-0s7ok4uw	4716	8	potentials	potential	NNS
cord-001835-0s7ok4uw	4716	9	,	,	,
cord-001835-0s7ok4uw	4716	10	residue	residue	JJ
cord-001835-0s7ok4uw	4716	11	level	level	NN
cord-001835-0s7ok4uw	4716	12	potentials	potential	NNS
cord-001835-0s7ok4uw	4716	13	,	,	,
cord-001835-0s7ok4uw	4716	14	or	or	CC
cord-001835-0s7ok4uw	4716	15	a	a	DT
cord-001835-0s7ok4uw	4716	16	combination	combination	NN
cord-001835-0s7ok4uw	4716	17	of	of	IN
cord-001835-0s7ok4uw	4716	18	both	both	DT
cord-001835-0s7ok4uw	4716	19	.	.	.
cord-001835-0s7ok4uw	4717	1	In	in	IN
cord-001835-0s7ok4uw	4717	2	current	current	JJ
cord-001835-0s7ok4uw	4717	3	work	work	NN
cord-001835-0s7ok4uw	4717	4	,	,	,
cord-001835-0s7ok4uw	4717	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4717	6	have	have	VBP
cord-001835-0s7ok4uw	4717	7	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	4717	8	73	73	CD
cord-001835-0s7ok4uw	4717	9	different	different	JJ
cord-001835-0s7ok4uw	4717	10	SF	SF	NNP
cord-001835-0s7ok4uw	4717	11	,	,	,
cord-001835-0s7ok4uw	4717	12	taken	take	VBN
cord-001835-0s7ok4uw	4717	13	from	from	IN
cord-001835-0s7ok4uw	4717	14	Cchappi	Cchappi	NNP
cord-001835-0s7ok4uw	4717	15	server	server	NN
cord-001835-0s7ok4uw	4717	16	,	,	,
cord-001835-0s7ok4uw	4717	17	on	on	IN
cord-001835-0s7ok4uw	4717	18	the	the	DT
cord-001835-0s7ok4uw	4717	19	results	result	NNS
cord-001835-0s7ok4uw	4717	20	of	of	IN
cord-001835-0s7ok4uw	4717	21	3	3	CD
cord-001835-0s7ok4uw	4717	22	different	different	JJ
cord-001835-0s7ok4uw	4717	23	rigid	rigid	JJ
cord-001835-0s7ok4uw	4717	24	body	body	NN
cord-001835-0s7ok4uw	4717	25	docking	docking	NN
cord-001835-0s7ok4uw	4717	26	methods	method	NNS
cord-001835-0s7ok4uw	4717	27	,	,	,
cord-001835-0s7ok4uw	4717	28	Ftdock	Ftdock	NNP
cord-001835-0s7ok4uw	4717	29	,	,	,
cord-001835-0s7ok4uw	4717	30	Zdock	Zdock	NNP
cord-001835-0s7ok4uw	4717	31	,	,	,
cord-001835-0s7ok4uw	4717	32	and	and	CC
cord-001835-0s7ok4uw	4717	33	Sdock	Sdock	NNP
cord-001835-0s7ok4uw	4717	34	,	,	,
cord-001835-0s7ok4uw	4717	35	using	use	VBG
cord-001835-0s7ok4uw	4717	36	the	the	DT
cord-001835-0s7ok4uw	4717	37	docking	docking	NN
cord-001835-0s7ok4uw	4717	38	benchmark	benchmark	NN
cord-001835-0s7ok4uw	4717	39	4.0	4.0	CD
cord-001835-0s7ok4uw	4717	40	and	and	CC
cord-001835-0s7ok4uw	4717	41	a	a	DT
cord-001835-0s7ok4uw	4717	42	docking	docking	NN
cord-001835-0s7ok4uw	4717	43	set	set	NN
cord-001835-0s7ok4uw	4717	44	built	build	VBN
cord-001835-0s7ok4uw	4717	45	from	from	IN
cord-001835-0s7ok4uw	4717	46	CAPRI	CAPRI	NNP
cord-001835-0s7ok4uw	4717	47	scorers	scorer	NNS
cord-001835-0s7ok4uw	4717	48	experiment	experiment	NN
cord-001835-0s7ok4uw	4717	49	.	.	.
cord-001835-0s7ok4uw	4718	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4718	2	results	result	NNS
cord-001835-0s7ok4uw	4718	3	show	show	VBP
cord-001835-0s7ok4uw	4718	4	9	9	CD
cord-001835-0s7ok4uw	4718	5	SF	SF	NNP
cord-001835-0s7ok4uw	4718	6	that	that	WDT
cord-001835-0s7ok4uw	4718	7	showed	show	VBD
cord-001835-0s7ok4uw	4718	8	better	well	RBR
cord-001835-0s7ok4uw	4718	9	or	or	CC
cord-001835-0s7ok4uw	4718	10	similar	similar	JJ
cord-001835-0s7ok4uw	4718	11	success	success	NN
cord-001835-0s7ok4uw	4718	12	rate	rate	NN
cord-001835-0s7ok4uw	4718	13	than	than	IN
cord-001835-0s7ok4uw	4718	14	the	the	DT
cord-001835-0s7ok4uw	4718	15	in	in	RB
cord-001835-0s7ok4uw	4718	16	-	-	HYPH
cord-001835-0s7ok4uw	4718	17	built	build	VBN
cord-001835-0s7ok4uw	4718	18	SF	SF	NNP
cord-001835-0s7ok4uw	4718	19	.	.	.
cord-001835-0s7ok4uw	4719	1	Some	some	DT
cord-001835-0s7ok4uw	4719	2	of	of	IN
cord-001835-0s7ok4uw	4719	3	these	these	DT
cord-001835-0s7ok4uw	4719	4	SF	SF	NNP
cord-001835-0s7ok4uw	4719	5	increase	increase	VB
cord-001835-0s7ok4uw	4719	6	the	the	DT
cord-001835-0s7ok4uw	4719	7	docking	docking	NN
cord-001835-0s7ok4uw	4719	8	success	success	NN
cord-001835-0s7ok4uw	4719	9	rates	rate	NNS
cord-001835-0s7ok4uw	4719	10	especially	especially	RB
cord-001835-0s7ok4uw	4719	11	for	for	IN
cord-001835-0s7ok4uw	4719	12	flexible	flexible	JJ
cord-001835-0s7ok4uw	4719	13	or	or	CC
cord-001835-0s7ok4uw	4719	14	weak	weak	JJ
cord-001835-0s7ok4uw	4719	15	-	-	HYPH
cord-001835-0s7ok4uw	4719	16	binding	bind	VBG
cord-001835-0s7ok4uw	4719	17	cases	case	NNS
cord-001835-0s7ok4uw	4719	18	,	,	,
cord-001835-0s7ok4uw	4719	19	which	which	WDT
cord-001835-0s7ok4uw	4719	20	are	be	VBP
cord-001835-0s7ok4uw	4719	21	the	the	DT
cord-001835-0s7ok4uw	4719	22	most	most	RBS
cord-001835-0s7ok4uw	4719	23	challenging	challenging	JJ
cord-001835-0s7ok4uw	4719	24	for	for	IN
cord-001835-0s7ok4uw	4719	25	docking	docking	NN
cord-001835-0s7ok4uw	4719	26	.	.	.
cord-001835-0s7ok4uw	4720	1	6	6	CD
cord-001835-0s7ok4uw	4720	2	of	of	IN
cord-001835-0s7ok4uw	4720	3	them	-PRON-	PRP
cord-001835-0s7ok4uw	4720	4	are	be	VBP
cord-001835-0s7ok4uw	4720	5	residue	residue	JJ
cord-001835-0s7ok4uw	4720	6	level	level	NN
cord-001835-0s7ok4uw	4720	7	SF	SF	NNP
cord-001835-0s7ok4uw	4720	8	robust	robust	JJ
cord-001835-0s7ok4uw	4720	9	enough	enough	RB
cord-001835-0s7ok4uw	4720	10	to	to	TO
cord-001835-0s7ok4uw	4720	11	detected	detect	VBN
cord-001835-0s7ok4uw	4720	12	solutions	solution	NNS
cord-001835-0s7ok4uw	4720	13	in	in	IN
cord-001835-0s7ok4uw	4720	14	cases	case	NNS
cord-001835-0s7ok4uw	4720	15	with	with	IN
cord-001835-0s7ok4uw	4720	16	large	large	JJ
cord-001835-0s7ok4uw	4720	17	conformation	conformation	NN
cord-001835-0s7ok4uw	4720	18	change	change	NN
cord-001835-0s7ok4uw	4720	19	.	.	.
cord-001835-0s7ok4uw	4721	1	In	in	IN
cord-001835-0s7ok4uw	4721	2	particular	particular	JJ
cord-001835-0s7ok4uw	4721	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4721	4	found	find	VBD
cord-001835-0s7ok4uw	4721	5	two	two	CD
cord-001835-0s7ok4uw	4721	6	SF	SF	NNP
cord-001835-0s7ok4uw	4721	7	that	that	WDT
cord-001835-0s7ok4uw	4721	8	shows	show	VBZ
cord-001835-0s7ok4uw	4721	9	outstanding	outstanding	JJ
cord-001835-0s7ok4uw	4721	10	robustness	robustness	NN
cord-001835-0s7ok4uw	4721	11	,	,	,
cord-001835-0s7ok4uw	4721	12	one	one	CD
cord-001835-0s7ok4uw	4721	13	designed	design	VBN
cord-001835-0s7ok4uw	4721	14	for	for	IN
cord-001835-0s7ok4uw	4721	15	protein	protein	NN
cord-001835-0s7ok4uw	4721	16	modeling	modeling	NN
cord-001835-0s7ok4uw	4721	17	and	and	CC
cord-001835-0s7ok4uw	4721	18	shared	share	VBD
cord-001835-0s7ok4uw	4721	19	among	among	IN
cord-001835-0s7ok4uw	4721	20	docking	docking	NN
cord-001835-0s7ok4uw	4721	21	methods	method	NNS
cord-001835-0s7ok4uw	4721	22	,	,	,
cord-001835-0s7ok4uw	4721	23	and	and	CC
cord-001835-0s7ok4uw	4721	24	the	the	DT
cord-001835-0s7ok4uw	4721	25	other	other	JJ
cord-001835-0s7ok4uw	4721	26	is	be	VBZ
cord-001835-0s7ok4uw	4721	27	for	for	IN
cord-001835-0s7ok4uw	4721	28	protein	protein	NN
cord-001835-0s7ok4uw	4721	29	docking	docking	NN
cord-001835-0s7ok4uw	4721	30	which	which	WDT
cord-001835-0s7ok4uw	4721	31	is	be	VBZ
cord-001835-0s7ok4uw	4721	32	also	also	RB
cord-001835-0s7ok4uw	4721	33	the	the	DT
cord-001835-0s7ok4uw	4721	34	best	good	JJS
cord-001835-0s7ok4uw	4721	35	success	success	NN
cord-001835-0s7ok4uw	4721	36	rate	rate	NN
cord-001835-0s7ok4uw	4721	37	in	in	IN
cord-001835-0s7ok4uw	4721	38	the	the	DT
cord-001835-0s7ok4uw	4721	39	top100	top100	JJ
cord-001835-0s7ok4uw	4721	40	ranking	ranking	NN
cord-001835-0s7ok4uw	4721	41	in	in	IN
cord-001835-0s7ok4uw	4721	42	the	the	DT
cord-001835-0s7ok4uw	4721	43	CAPRI	CAPRI	NNP
cord-001835-0s7ok4uw	4721	44	scorers	scorer	NNS
cord-001835-0s7ok4uw	4721	45	set	set	VBN
cord-001835-0s7ok4uw	4721	46	.	.	.
cord-001835-0s7ok4uw	4722	1	The	the	DT
cord-001835-0s7ok4uw	4722	2	other	other	JJ
cord-001835-0s7ok4uw	4722	3	3	3	CD
cord-001835-0s7ok4uw	4722	4	atomic	atomic	JJ
cord-001835-0s7ok4uw	4722	5	level	level	NN
cord-001835-0s7ok4uw	4722	6	SF	SF	NNP
cord-001835-0s7ok4uw	4722	7	display	display	NN
cord-001835-0s7ok4uw	4722	8	high	high	JJ
cord-001835-0s7ok4uw	4722	9	success	success	NN
cord-001835-0s7ok4uw	4722	10	rate	rate	NN
cord-001835-0s7ok4uw	4722	11	to	to	TO
cord-001835-0s7ok4uw	4722	12	find	find	VB
cord-001835-0s7ok4uw	4722	13	a	a	DT
cord-001835-0s7ok4uw	4722	14	solution	solution	NN
cord-001835-0s7ok4uw	4722	15	within	within	IN
cord-001835-0s7ok4uw	4722	16	weak	weak	JJ
cord-001835-0s7ok4uw	4722	17	binding	binding	NN
cord-001835-0s7ok4uw	4722	18	proteins	protein	NNS
cord-001835-0s7ok4uw	4722	19	.	.	.
cord-001835-0s7ok4uw	4723	1	The	the	DT
cord-001835-0s7ok4uw	4723	2	2	2	CD
cord-001835-0s7ok4uw	4723	3	most	most	RBS
cord-001835-0s7ok4uw	4723	4	successful	successful	JJ
cord-001835-0s7ok4uw	4723	5	SF	SF	NNP
cord-001835-0s7ok4uw	4723	6	are	be	VBP
cord-001835-0s7ok4uw	4723	7	shared	share	VBN
cord-001835-0s7ok4uw	4723	8	between	between	IN
cord-001835-0s7ok4uw	4723	9	the	the	DT
cord-001835-0s7ok4uw	4723	10	docking	docking	NN
cord-001835-0s7ok4uw	4723	11	methods	method	NNS
cord-001835-0s7ok4uw	4723	12	and	and	CC
cord-001835-0s7ok4uw	4723	13	display	display	VB
cord-001835-0s7ok4uw	4723	14	high	high	JJ
cord-001835-0s7ok4uw	4723	15	success	success	NN
cord-001835-0s7ok4uw	4723	16	rate	rate	NN
cord-001835-0s7ok4uw	4723	17	in	in	IN
cord-001835-0s7ok4uw	4723	18	the	the	DT
cord-001835-0s7ok4uw	4723	19	hard	hard	JJ
cord-001835-0s7ok4uw	4723	20	cases	case	NNS
cord-001835-0s7ok4uw	4723	21	of	of	IN
cord-001835-0s7ok4uw	4723	22	the	the	DT
cord-001835-0s7ok4uw	4723	23	benchmark	benchmark	JJ
cord-001835-0s7ok4uw	4723	24	4.0	4.0	CD
cord-001835-0s7ok4uw	4723	25	and	and	CC
cord-001835-0s7ok4uw	4723	26	in	in	IN
cord-001835-0s7ok4uw	4723	27	the	the	DT
cord-001835-0s7ok4uw	4723	28	CAPRI	CAPRI	NNP
cord-001835-0s7ok4uw	4723	29	scorers	scorer	NNS
cord-001835-0s7ok4uw	4723	30	set	set	VBN
cord-001835-0s7ok4uw	4723	31	.	.	.
cord-001835-0s7ok4uw	4724	1	The	the	DT
cord-001835-0s7ok4uw	4724	2	difference	difference	NN
cord-001835-0s7ok4uw	4724	3	between	between	IN
cord-001835-0s7ok4uw	4724	4	them	-PRON-	PRP
cord-001835-0s7ok4uw	4724	5	in	in	IN
cord-001835-0s7ok4uw	4724	6	the	the	DT
cord-001835-0s7ok4uw	4724	7	resolution	resolution	NN
cord-001835-0s7ok4uw	4724	8	level	level	NN
cord-001835-0s7ok4uw	4724	9	at	at	IN
cord-001835-0s7ok4uw	4724	10	which	which	WDT
cord-001835-0s7ok4uw	4724	11	they	-PRON-	PRP
cord-001835-0s7ok4uw	4724	12	work	work	VBP
cord-001835-0s7ok4uw	4724	13	,	,	,
cord-001835-0s7ok4uw	4724	14	one	one	CD
cord-001835-0s7ok4uw	4724	15	being	be	VBG
cord-001835-0s7ok4uw	4724	16	atomistic	atomistic	JJ
cord-001835-0s7ok4uw	4724	17	the	the	DT
cord-001835-0s7ok4uw	4724	18	other	other	JJ
cord-001835-0s7ok4uw	4724	19	residue	residue	NN
cord-001835-0s7ok4uw	4724	20	-	-	HYPH
cord-001835-0s7ok4uw	4724	21	based	base	VBN
cord-001835-0s7ok4uw	4724	22	.	.	.
cord-001835-0s7ok4uw	4725	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4725	2	found	find	VBD
cord-001835-0s7ok4uw	4725	3	that	that	IN
cord-001835-0s7ok4uw	4725	4	they	-PRON-	PRP
cord-001835-0s7ok4uw	4725	5	success	success	NN
cord-001835-0s7ok4uw	4725	6	rate	rate	NN
cord-001835-0s7ok4uw	4725	7	vary	vary	VBP
cord-001835-0s7ok4uw	4725	8	according	accord	VBG
cord-001835-0s7ok4uw	4725	9	to	to	IN
cord-001835-0s7ok4uw	4725	10	the	the	DT
cord-001835-0s7ok4uw	4725	11	docking	docking	NN
cord-001835-0s7ok4uw	4725	12	method	method	NN
cord-001835-0s7ok4uw	4725	13	chosen	choose	VBN
cord-001835-0s7ok4uw	4725	14	,	,	,
cord-001835-0s7ok4uw	4725	15	allowing	allow	VBG
cord-001835-0s7ok4uw	4725	16	them	-PRON-	PRP
cord-001835-0s7ok4uw	4725	17	to	to	TO
cord-001835-0s7ok4uw	4725	18	explode	explode	VB
cord-001835-0s7ok4uw	4725	19	different	different	JJ
cord-001835-0s7ok4uw	4725	20	properties	property	NNS
cord-001835-0s7ok4uw	4725	21	of	of	IN
cord-001835-0s7ok4uw	4725	22	the	the	DT
cord-001835-0s7ok4uw	4725	23	sampling	sampling	NN
cord-001835-0s7ok4uw	4725	24	used	use	VBN
cord-001835-0s7ok4uw	4725	25	.	.	.
cord-001835-0s7ok4uw	4726	1	This	this	DT
cord-001835-0s7ok4uw	4726	2	way	way	NN
cord-001835-0s7ok4uw	4726	3	to	to	TO
cord-001835-0s7ok4uw	4726	4	characterize	characterize	VB
cord-001835-0s7ok4uw	4726	5	a	a	DT
cord-001835-0s7ok4uw	4726	6	protein	protein	NN
cord-001835-0s7ok4uw	4726	7	complex	complex	NN
cord-001835-0s7ok4uw	4726	8	can	can	MD
cord-001835-0s7ok4uw	4726	9	help	help	VB
cord-001835-0s7ok4uw	4726	10	to	to	TO
cord-001835-0s7ok4uw	4726	11	develop	develop	VB
cord-001835-0s7ok4uw	4726	12	new	new	JJ
cord-001835-0s7ok4uw	4726	13	combined	combine	VBN
cord-001835-0s7ok4uw	4726	14	scoring	scoring	NN
cord-001835-0s7ok4uw	4726	15	functions	function	NNS
cord-001835-0s7ok4uw	4726	16	in	in	IN
cord-001835-0s7ok4uw	4726	17	protein	protein	NN
cord-001835-0s7ok4uw	4726	18	docking	docking	NN
cord-001835-0s7ok4uw	4726	19	or	or	CC
cord-001835-0s7ok4uw	4726	20	a	a	DT
cord-001835-0s7ok4uw	4726	21	new	new	JJ
cord-001835-0s7ok4uw	4726	22	ranking	rank	VBG
cord-001835-0s7ok4uw	4726	23	strategy	strategy	NN
cord-001835-0s7ok4uw	4726	24	to	to	TO
cord-001835-0s7ok4uw	4726	25	enhance	enhance	VB
cord-001835-0s7ok4uw	4726	26	the	the	DT
cord-001835-0s7ok4uw	4726	27	success	success	NN
cord-001835-0s7ok4uw	4726	28	rate	rate	NN
cord-001835-0s7ok4uw	4726	29	.	.	.
cord-001835-0s7ok4uw	4727	1	Multi	Multi	NNP
cord-001835-0s7ok4uw	4727	2	-	-	JJ
cord-001835-0s7ok4uw	4727	3	PTK	PTK	NNP
cord-001835-0s7ok4uw	4727	4	antibody	antibody	NN
cord-001835-0s7ok4uw	4727	5	:	:	:
cord-001835-0s7ok4uw	4727	6	a	a	DT
cord-001835-0s7ok4uw	4727	7	powerful	powerful	JJ
cord-001835-0s7ok4uw	4727	8	tool	tool	NN
cord-001835-0s7ok4uw	4727	9	to	to	TO
cord-001835-0s7ok4uw	4727	10	detect	detect	VB
cord-001835-0s7ok4uw	4727	11	a	a	DT
cord-001835-0s7ok4uw	4727	12	wide	wide	JJ
cord-001835-0s7ok4uw	4727	13	variety	variety	NN
cord-001835-0s7ok4uw	4727	14	of	of	IN
cord-001835-0s7ok4uw	4727	15	protein	protein	NN
cord-001835-0s7ok4uw	4727	16	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	4727	17	kinases	kinase	NNS
cord-001835-0s7ok4uw	4727	18	(	(	-LRB-
cord-001835-0s7ok4uw	4727	19	PTKs	PTKs	NNP
cord-001835-0s7ok4uw	4727	20	)	)	-RRB-
cord-001835-0s7ok4uw	4728	1	Isamu	Isamu	NNP
cord-001835-0s7ok4uw	4728	2	Kameshita	Kameshita	NNP
cord-001835-0s7ok4uw	4728	3	1	1	CD
cord-001835-0s7ok4uw	4728	4	,	,	,
cord-001835-0s7ok4uw	4728	5	Noriyuki	Noriyuki	NNP
cord-001835-0s7ok4uw	4728	6	Sueyoshi	Sueyoshi	NNP
cord-001835-0s7ok4uw	4728	7	1	1	CD
cord-001835-0s7ok4uw	4728	8	,	,	,
cord-001835-0s7ok4uw	4728	9	Yasunori	Yasunori	NNP
cord-001835-0s7ok4uw	4728	10	Sugiyama	Sugiyama	NNP
cord-001835-0s7ok4uw	4728	11	1	1	CD
cord-001835-0s7ok4uw	4728	12	1	1	CD
cord-001835-0s7ok4uw	4729	1	The	the	DT
cord-001835-0s7ok4uw	4729	2	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	4729	3	protein	protein	NN
cord-001835-0s7ok4uw	4729	4	kinases	kinase	NNS
cord-001835-0s7ok4uw	4729	5	consist	consist	VBP
cord-001835-0s7ok4uw	4729	6	of	of	IN
cord-001835-0s7ok4uw	4729	7	large	large	JJ
cord-001835-0s7ok4uw	4729	8	families	family	NNS
cord-001835-0s7ok4uw	4729	9	of	of	IN
cord-001835-0s7ok4uw	4729	10	homologous	homologous	JJ
cord-001835-0s7ok4uw	4729	11	proteins	protein	NNS
cord-001835-0s7ok4uw	4729	12	and	and	CC
cord-001835-0s7ok4uw	4729	13	play	play	VB
cord-001835-0s7ok4uw	4729	14	pivotal	pivotal	JJ
cord-001835-0s7ok4uw	4729	15	roles	role	NNS
cord-001835-0s7ok4uw	4729	16	in	in	IN
cord-001835-0s7ok4uw	4729	17	various	various	JJ
cord-001835-0s7ok4uw	4729	18	cellular	cellular	JJ
cord-001835-0s7ok4uw	4729	19	functions	function	NNS
cord-001835-0s7ok4uw	4729	20	.	.	.
cord-001835-0s7ok4uw	4730	1	These	these	DT
cord-001835-0s7ok4uw	4730	2	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4730	3	are	be	VBP
cord-001835-0s7ok4uw	4730	4	classified	classify	VBN
cord-001835-0s7ok4uw	4730	5	into	into	IN
cord-001835-0s7ok4uw	4730	6	two	two	CD
cord-001835-0s7ok4uw	4730	7	major	major	JJ
cord-001835-0s7ok4uw	4730	8	groups	group	NNS
cord-001835-0s7ok4uw	4730	9	;	;	:
cord-001835-0s7ok4uw	4730	10	protein	protein	NN
cord-001835-0s7ok4uw	4730	11	serine	serine	NN
cord-001835-0s7ok4uw	4730	12	/	/	SYM
cord-001835-0s7ok4uw	4730	13	threonine	threonine	NN
cord-001835-0s7ok4uw	4730	14	kinases	kinase	NNS
cord-001835-0s7ok4uw	4730	15	and	and	CC
cord-001835-0s7ok4uw	4730	16	protein	protein	NN
cord-001835-0s7ok4uw	4730	17	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	4730	18	kinases	kinase	NNS
cord-001835-0s7ok4uw	4730	19	(	(	-LRB-
cord-001835-0s7ok4uw	4730	20	PTKs	PTKs	NNP
cord-001835-0s7ok4uw	4730	21	)	)	-RRB-
cord-001835-0s7ok4uw	4730	22	.	.	.
cord-001835-0s7ok4uw	4731	1	PTKs	PTKs	NNP
cord-001835-0s7ok4uw	4731	2	are	be	VBP
cord-001835-0s7ok4uw	4731	3	believed	believe	VBN
cord-001835-0s7ok4uw	4731	4	to	to	TO
cord-001835-0s7ok4uw	4731	5	be	be	VB
cord-001835-0s7ok4uw	4731	6	involved	involve	VBN
cord-001835-0s7ok4uw	4731	7	in	in	IN
cord-001835-0s7ok4uw	4731	8	various	various	JJ
cord-001835-0s7ok4uw	4731	9	cellular	cellular	JJ
cord-001835-0s7ok4uw	4731	10	events	event	NNS
cord-001835-0s7ok4uw	4731	11	such	such	JJ
cord-001835-0s7ok4uw	4731	12	as	as	IN
cord-001835-0s7ok4uw	4731	13	cell	cell	NN
cord-001835-0s7ok4uw	4731	14	cycle	cycle	NN
cord-001835-0s7ok4uw	4731	15	,	,	,
cord-001835-0s7ok4uw	4731	16	proliferation	proliferation	NN
cord-001835-0s7ok4uw	4731	17	,	,	,
cord-001835-0s7ok4uw	4731	18	differentiation	differentiation	NN
cord-001835-0s7ok4uw	4731	19	,	,	,
cord-001835-0s7ok4uw	4731	20	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	4731	21	,	,	,
cord-001835-0s7ok4uw	4731	22	and	and	CC
cord-001835-0s7ok4uw	4731	23	cell	cell	NN
cord-001835-0s7ok4uw	4731	24	adhesion	adhesion	NN
cord-001835-0s7ok4uw	4731	25	in	in	IN
cord-001835-0s7ok4uw	4731	26	multicellular	multicellular	JJ
cord-001835-0s7ok4uw	4731	27	eukaryotes	eukaryote	NNS
cord-001835-0s7ok4uw	4731	28	.	.	.
cord-001835-0s7ok4uw	4732	1	As	as	RB
cord-001835-0s7ok4uw	4732	2	many	many	JJ
cord-001835-0s7ok4uw	4732	3	as	as	IN
cord-001835-0s7ok4uw	4732	4	90	90	CD
cord-001835-0s7ok4uw	4732	5	PTK	PTK	NNP
cord-001835-0s7ok4uw	4732	6	genes	gene	NNS
cord-001835-0s7ok4uw	4732	7	have	have	VBP
cord-001835-0s7ok4uw	4732	8	been	be	VBN
cord-001835-0s7ok4uw	4732	9	identified	identify	VBN
cord-001835-0s7ok4uw	4732	10	in	in	IN
cord-001835-0s7ok4uw	4732	11	the	the	DT
cord-001835-0s7ok4uw	4732	12	human	human	JJ
cord-001835-0s7ok4uw	4732	13	genome	genome	NN
cord-001835-0s7ok4uw	4732	14	and	and	CC
cord-001835-0s7ok4uw	4732	15	many	many	JJ
cord-001835-0s7ok4uw	4732	16	of	of	IN
cord-001835-0s7ok4uw	4732	17	these	these	DT
cord-001835-0s7ok4uw	4732	18	PTKs	ptk	NNS
cord-001835-0s7ok4uw	4732	19	are	be	VBP
cord-001835-0s7ok4uw	4732	20	known	know	VBN
cord-001835-0s7ok4uw	4732	21	to	to	TO
cord-001835-0s7ok4uw	4732	22	be	be	VB
cord-001835-0s7ok4uw	4732	23	closely	closely	RB
cord-001835-0s7ok4uw	4732	24	correlated	correlate	VBN
cord-001835-0s7ok4uw	4732	25	with	with	IN
cord-001835-0s7ok4uw	4732	26	various	various	JJ
cord-001835-0s7ok4uw	4732	27	diseases	disease	NNS
cord-001835-0s7ok4uw	4732	28	such	such	JJ
cord-001835-0s7ok4uw	4732	29	as	as	IN
cord-001835-0s7ok4uw	4732	30	cancer	cancer	NN
cord-001835-0s7ok4uw	4732	31	.	.	.
cord-001835-0s7ok4uw	4733	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	4733	2	,	,	,
cord-001835-0s7ok4uw	4733	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	4733	4	is	be	VBZ
cord-001835-0s7ok4uw	4733	5	important	important	JJ
cord-001835-0s7ok4uw	4733	6	to	to	TO
cord-001835-0s7ok4uw	4733	7	elucidate	elucidate	VB
cord-001835-0s7ok4uw	4733	8	the	the	DT
cord-001835-0s7ok4uw	4733	9	expression	expression	NN
cord-001835-0s7ok4uw	4733	10	profiles	profile	NNS
cord-001835-0s7ok4uw	4733	11	of	of	IN
cord-001835-0s7ok4uw	4733	12	the	the	DT
cord-001835-0s7ok4uw	4733	13	entire	entire	JJ
cord-001835-0s7ok4uw	4733	14	PTK	PTK	NNP
cord-001835-0s7ok4uw	4733	15	family	family	NN
cord-001835-0s7ok4uw	4733	16	in	in	IN
cord-001835-0s7ok4uw	4733	17	cells	cell	NNS
cord-001835-0s7ok4uw	4733	18	and	and	CC
cord-001835-0s7ok4uw	4733	19	tissues	tissue	NNS
cord-001835-0s7ok4uw	4733	20	.	.	.
cord-001835-0s7ok4uw	4734	1	To	to	TO
cord-001835-0s7ok4uw	4734	2	investigate	investigate	VB
cord-001835-0s7ok4uw	4734	3	the	the	DT
cord-001835-0s7ok4uw	4734	4	expression	expression	NN
cord-001835-0s7ok4uw	4734	5	profiles	profile	NNS
cord-001835-0s7ok4uw	4734	6	of	of	IN
cord-001835-0s7ok4uw	4734	7	the	the	DT
cord-001835-0s7ok4uw	4734	8	cellular	cellular	JJ
cord-001835-0s7ok4uw	4734	9	PTKs	ptk	NNS
cord-001835-0s7ok4uw	4734	10	,	,	,
cord-001835-0s7ok4uw	4734	11	we	-PRON-	PRP
cord-001835-0s7ok4uw	4734	12	produced	produce	VBD
cord-001835-0s7ok4uw	4734	13	an	an	DT
cord-001835-0s7ok4uw	4734	14	antibody	antibody	NN
cord-001835-0s7ok4uw	4734	15	that	that	WDT
cord-001835-0s7ok4uw	4734	16	detects	detect	VBZ
cord-001835-0s7ok4uw	4734	17	a	a	DT
cord-001835-0s7ok4uw	4734	18	wide	wide	JJ
cord-001835-0s7ok4uw	4734	19	variety	variety	NN
cord-001835-0s7ok4uw	4734	20	of	of	IN
cord-001835-0s7ok4uw	4734	21	PTKs	ptk	NNS
cord-001835-0s7ok4uw	4734	22	.	.	.
cord-001835-0s7ok4uw	4735	1	For	for	IN
cord-001835-0s7ok4uw	4735	2	production	production	NN
cord-001835-0s7ok4uw	4735	3	of	of	IN
cord-001835-0s7ok4uw	4735	4	the	the	DT
cord-001835-0s7ok4uw	4735	5	antibody	antibody	NN
cord-001835-0s7ok4uw	4735	6	,	,	,
cord-001835-0s7ok4uw	4735	7	antigenic	antigenic	JJ
cord-001835-0s7ok4uw	4735	8	peptides	peptide	NNS
cord-001835-0s7ok4uw	4735	9	corresponding	correspond	VBG
cord-001835-0s7ok4uw	4735	10	to	to	IN
cord-001835-0s7ok4uw	4735	11	amino	amino	NN
cord-001835-0s7ok4uw	4735	12	acid	acid	NN
cord-001835-0s7ok4uw	4735	13	sequences	sequence	NNS
cord-001835-0s7ok4uw	4735	14	of	of	IN
cord-001835-0s7ok4uw	4735	15	a	a	DT
cord-001835-0s7ok4uw	4735	16	highly	highly	RB
cord-001835-0s7ok4uw	4735	17	conserved	conserve	VBN
cord-001835-0s7ok4uw	4735	18	region	region	NN
cord-001835-0s7ok4uw	4735	19	(	(	-LRB-
cord-001835-0s7ok4uw	4735	20	subdomain	subdomain	NN
cord-001835-0s7ok4uw	4735	21	VIB	VIB	NNP
cord-001835-0s7ok4uw	4735	22	)	)	-RRB-
cord-001835-0s7ok4uw	4735	23	of	of	IN
cord-001835-0s7ok4uw	4735	24	PTKs	PTKs	NNPS
cord-001835-0s7ok4uw	4735	25	were	be	VBD
cord-001835-0s7ok4uw	4735	26	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	4735	27	and	and	CC
cord-001835-0s7ok4uw	4735	28	immunized	immunize	VBN
cord-001835-0s7ok4uw	4735	29	to	to	IN
cord-001835-0s7ok4uw	4735	30	BALB	BALB	NNP
cord-001835-0s7ok4uw	4735	31	/	/	SYM
cord-001835-0s7ok4uw	4735	32	c	c	NN
cord-001835-0s7ok4uw	4735	33	mice	mouse	NNS
cord-001835-0s7ok4uw	4735	34	.	.	.
cord-001835-0s7ok4uw	4736	1	Among	among	IN
cord-001835-0s7ok4uw	4736	2	various	various	JJ
cord-001835-0s7ok4uw	4736	3	antigens	antigen	NNS
cord-001835-0s7ok4uw	4736	4	,	,	,
cord-001835-0s7ok4uw	4736	5	a	a	DT
cord-001835-0s7ok4uw	4736	6	peptide	peptide	NN
cord-001835-0s7ok4uw	4736	7	with	with	IN
cord-001835-0s7ok4uw	4736	8	11	11	CD
cord-001835-0s7ok4uw	4736	9	amino	amino	JJ
cord-001835-0s7ok4uw	4736	10	acids	acid	NNS
cord-001835-0s7ok4uw	4736	11	,	,	,
cord-001835-0s7ok4uw	4736	12	CYVHRDLRAAN	CYVHRDLRAAN	NNP
cord-001835-0s7ok4uw	4736	13	,	,	,
cord-001835-0s7ok4uw	4736	14	efficiently	efficiently	RB
cord-001835-0s7ok4uw	4736	15	produced	produce	VBD
cord-001835-0s7ok4uw	4736	16	a	a	DT
cord-001835-0s7ok4uw	4736	17	polyclonal	polyclonal	JJ
cord-001835-0s7ok4uw	4736	18	antibody	antibody	NN
cord-001835-0s7ok4uw	4736	19	with	with	IN
cord-001835-0s7ok4uw	4736	20	a	a	DT
cord-001835-0s7ok4uw	4736	21	broad	broad	JJ
cord-001835-0s7ok4uw	4736	22	reactivity	reactivity	NN
cord-001835-0s7ok4uw	4736	23	to	to	IN
cord-001835-0s7ok4uw	4736	24	PTKs	PTKs	NNP
cord-001835-0s7ok4uw	4736	25	.	.	.
cord-001835-0s7ok4uw	4737	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4737	2	established	establish	VBD
cord-001835-0s7ok4uw	4737	3	a	a	DT
cord-001835-0s7ok4uw	4737	4	hybridoma	hybridoma	NN
cord-001835-0s7ok4uw	4737	5	cell	cell	NN
cord-001835-0s7ok4uw	4737	6	line	line	NN
cord-001835-0s7ok4uw	4737	7	producing	produce	VBG
cord-001835-0s7ok4uw	4737	8	a	a	DT
cord-001835-0s7ok4uw	4737	9	monoclonal	monoclonal	JJ
cord-001835-0s7ok4uw	4737	10	antibody	antibody	NN
cord-001835-0s7ok4uw	4737	11	,	,	,
cord-001835-0s7ok4uw	4737	12	YK34	YK34	NNP
cord-001835-0s7ok4uw	4737	13	,	,	,
cord-001835-0s7ok4uw	4737	14	which	which	WDT
cord-001835-0s7ok4uw	4737	15	appeared	appear	VBD
cord-001835-0s7ok4uw	4737	16	to	to	TO
cord-001835-0s7ok4uw	4737	17	cross	cross	VB
cord-001835-0s7ok4uw	4737	18	-	-	VB
cord-001835-0s7ok4uw	4737	19	react	react	VB
cord-001835-0s7ok4uw	4737	20	with	with	IN
cord-001835-0s7ok4uw	4737	21	various	various	JJ
cord-001835-0s7ok4uw	4737	22	PTKs	ptk	NNS
cord-001835-0s7ok4uw	4737	23	.	.	.
cord-001835-0s7ok4uw	4738	1	At	at	RB
cord-001835-0s7ok4uw	4738	2	least	least	RBS
cord-001835-0s7ok4uw	4738	3	68	68	CD
cord-001835-0s7ok4uw	4738	4	PTKs	ptk	NNS
cord-001835-0s7ok4uw	4738	5	could	could	MD
cord-001835-0s7ok4uw	4738	6	be	be	VB
cord-001835-0s7ok4uw	4738	7	detected	detect	VBN
cord-001835-0s7ok4uw	4738	8	by	by	IN
cord-001835-0s7ok4uw	4738	9	YK34	YK34	NNP
cord-001835-0s7ok4uw	4738	10	antibody	antibody	NN
cord-001835-0s7ok4uw	4738	11	,	,	,
cord-001835-0s7ok4uw	4738	12	as	as	IN
cord-001835-0s7ok4uw	4738	13	evidenced	evidence	VBN
cord-001835-0s7ok4uw	4738	14	by	by	IN
cord-001835-0s7ok4uw	4738	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4738	16	reactivity	reactivity	NN
cord-001835-0s7ok4uw	4738	17	with	with	IN
cord-001835-0s7ok4uw	4738	18	the	the	DT
cord-001835-0s7ok4uw	4738	19	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	4738	20	Src	Src	NNP
cord-001835-0s7ok4uw	4738	21	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	4738	22	kinases	kinase	NNS
cord-001835-0s7ok4uw	4738	23	whose	whose	WP$
cord-001835-0s7ok4uw	4738	24	subdomain	subdomain	NN
cord-001835-0s7ok4uw	4738	25	VIB	VIB	NNP
cord-001835-0s7ok4uw	4738	26	had	have	VBD
cord-001835-0s7ok4uw	4738	27	been	be	VBN
cord-001835-0s7ok4uw	4738	28	replaced	replace	VBN
cord-001835-0s7ok4uw	4738	29	by	by	IN
cord-001835-0s7ok4uw	4738	30	those	those	DT
cord-001835-0s7ok4uw	4738	31	of	of	IN
cord-001835-0s7ok4uw	4738	32	the	the	DT
cord-001835-0s7ok4uw	4738	33	other	other	JJ
cord-001835-0s7ok4uw	4738	34	PTKs	ptk	NNS
cord-001835-0s7ok4uw	4738	35	.	.	.
cord-001835-0s7ok4uw	4739	1	When	when	WRB
cord-001835-0s7ok4uw	4739	2	differentiated	differentiate	VBN
cord-001835-0s7ok4uw	4739	3	HL-60	HL-60	NNP
cord-001835-0s7ok4uw	4739	4	cells	cell	NNS
cord-001835-0s7ok4uw	4739	5	were	be	VBD
cord-001835-0s7ok4uw	4739	6	analyzed	analyze	VBN
cord-001835-0s7ok4uw	4739	7	by	by	IN
cord-001835-0s7ok4uw	4739	8	Western	western	JJ
cord-001835-0s7ok4uw	4739	9	blotting	blotting	NN
cord-001835-0s7ok4uw	4739	10	after	after	IN
cord-001835-0s7ok4uw	4739	11	two	two	CD
cord-001835-0s7ok4uw	4739	12	-	-	HYPH
cord-001835-0s7ok4uw	4739	13	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	4739	14	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	4739	15	with	with	IN
cord-001835-0s7ok4uw	4739	16	YK34	YK34	NNP
cord-001835-0s7ok4uw	4739	17	antibody	antibody	NN
cord-001835-0s7ok4uw	4739	18	,	,	,
cord-001835-0s7ok4uw	4739	19	we	-PRON-	PRP
cord-001835-0s7ok4uw	4739	20	observed	observe	VBD
cord-001835-0s7ok4uw	4739	21	significant	significant	JJ
cord-001835-0s7ok4uw	4739	22	changes	change	NNS
cord-001835-0s7ok4uw	4739	23	in	in	IN
cord-001835-0s7ok4uw	4739	24	the	the	DT
cord-001835-0s7ok4uw	4739	25	immunoreactive	immunoreactive	JJ
cord-001835-0s7ok4uw	4739	26	spots	spot	NNS
cord-001835-0s7ok4uw	4739	27	in	in	IN
cord-001835-0s7ok4uw	4739	28	HL-60	HL-60	NNP
cord-001835-0s7ok4uw	4739	29	cell	cell	NN
cord-001835-0s7ok4uw	4739	30	extracts	extract	NNS
cord-001835-0s7ok4uw	4739	31	along	along	IN
cord-001835-0s7ok4uw	4739	32	with	with	IN
cord-001835-0s7ok4uw	4739	33	the	the	DT
cord-001835-0s7ok4uw	4739	34	changes	change	NNS
cord-001835-0s7ok4uw	4739	35	in	in	IN
cord-001835-0s7ok4uw	4739	36	the	the	DT
cord-001835-0s7ok4uw	4739	37	morphology	morphology	NN
cord-001835-0s7ok4uw	4739	38	of	of	IN
cord-001835-0s7ok4uw	4739	39	the	the	DT
cord-001835-0s7ok4uw	4739	40	cells	cell	NNS
cord-001835-0s7ok4uw	4739	41	.	.	.
cord-001835-0s7ok4uw	4740	1	These	these	DT
cord-001835-0s7ok4uw	4740	2	results	result	NNS
cord-001835-0s7ok4uw	4740	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	4740	4	that	that	IN
cord-001835-0s7ok4uw	4740	5	the	the	DT
cord-001835-0s7ok4uw	4740	6	Multi	Multi	NNP
cord-001835-0s7ok4uw	4740	7	-	-	HYPH
cord-001835-0s7ok4uw	4740	8	PTK	PTK	NNP
cord-001835-0s7ok4uw	4740	9	antibody	antibody	NN
cord-001835-0s7ok4uw	4740	10	,	,	,
cord-001835-0s7ok4uw	4740	11	YK34	YK34	NNP
cord-001835-0s7ok4uw	4740	12	,	,	,
cord-001835-0s7ok4uw	4740	13	will	will	MD
cord-001835-0s7ok4uw	4740	14	be	be	VB
cord-001835-0s7ok4uw	4740	15	a	a	DT
cord-001835-0s7ok4uw	4740	16	powerful	powerful	JJ
cord-001835-0s7ok4uw	4740	17	tool	tool	NN
cord-001835-0s7ok4uw	4740	18	for	for	IN
cord-001835-0s7ok4uw	4740	19	the	the	DT
cord-001835-0s7ok4uw	4740	20	analysis	analysis	NN
cord-001835-0s7ok4uw	4740	21	of	of	IN
cord-001835-0s7ok4uw	4740	22	a	a	DT
cord-001835-0s7ok4uw	4740	23	variety	variety	NN
cord-001835-0s7ok4uw	4740	24	of	of	IN
cord-001835-0s7ok4uw	4740	25	cellular	cellular	JJ
cord-001835-0s7ok4uw	4740	26	PTKs	ptk	NNS
cord-001835-0s7ok4uw	4740	27	.	.	.
cord-001835-0s7ok4uw	4741	1	Analysis	analysis	NN
cord-001835-0s7ok4uw	4741	2	of	of	IN
cord-001835-0s7ok4uw	4741	3	the	the	DT
cord-001835-0s7ok4uw	4741	4	Siglec-9	Siglec-9	NNP
cord-001835-0s7ok4uw	4741	5	and	and	CC
cord-001835-0s7ok4uw	4741	6	hVAP-1	hvap-1	CD
cord-001835-0s7ok4uw	4741	7	interactions	interaction	NNS
cord-001835-0s7ok4uw	4741	8	Leonor	Leonor	NNP
cord-001835-0s7ok4uw	4741	9	Carvalho	Carvalho	NNP
cord-001835-0s7ok4uw	4741	10	1	1	CD
cord-001835-0s7ok4uw	4741	11	,	,	,
cord-001835-0s7ok4uw	4741	12	Vimal	Vimal	NNP
cord-001835-0s7ok4uw	4741	13	Parkash	Parkash	NNP
cord-001835-0s7ok4uw	4741	14	1	1	CD
cord-001835-0s7ok4uw	4742	1	,	,	,
cord-001835-0s7ok4uw	4742	2	Heli	Heli	NNP
cord-001835-0s7ok4uw	4742	3	Elovaara	Elovaara	NNP
cord-001835-0s7ok4uw	4742	4	2	2	CD
cord-001835-0s7ok4uw	4742	5	,	,	,
cord-001835-0s7ok4uw	4742	6	Sirpa	Sirpa	NNP
cord-001835-0s7ok4uw	4742	7	Jalkanen	Jalkanen	NNP
cord-001835-0s7ok4uw	4742	8	2	2	CD
cord-001835-0s7ok4uw	4742	9	,	,	,
cord-001835-0s7ok4uw	4742	10	Xiang	Xiang	NNP
cord-001835-0s7ok4uw	4742	11	-	-	HYPH
cord-001835-0s7ok4uw	4742	12	Guo	Guo	NNP
cord-001835-0s7ok4uw	4742	13	Li	Li	NNP
cord-001835-0s7ok4uw	4742	14	4	4	CD
cord-001835-0s7ok4uw	4742	15	,	,	,
cord-001835-0s7ok4uw	4742	16	Tiina	Tiina	NNP
cord-001835-0s7ok4uw	4742	17	Salminen	Salminen	NNP
cord-001835-0s7ok4uw	4742	18	1	1	CD
cord-001835-0s7ok4uw	4742	19	1	1	CD
cord-001835-0s7ok4uw	4742	20	Structural	Structural	NNP
cord-001835-0s7ok4uw	4742	21	Bionformatics	Bionformatics	NNP
cord-001835-0s7ok4uw	4742	22	Laboratory	Laboratory	NNP
cord-001835-0s7ok4uw	4742	23	,	,	,
cord-001835-0s7ok4uw	4742	24	Department	Department	NNP
cord-001835-0s7ok4uw	4742	25	of	of	IN
cord-001835-0s7ok4uw	4742	26	Biosciences	Biosciences	NNP
cord-001835-0s7ok4uw	4742	27	,	,	,
cord-001835-0s7ok4uw	4742	28	2	2	CD
cord-001835-0s7ok4uw	4742	29	MediCity	MediCity	NNP
cord-001835-0s7ok4uw	4742	30	Research	Research	NNP
cord-001835-0s7ok4uw	4742	31	Laboratory	Laboratory	NNP
cord-001835-0s7ok4uw	4742	32	,	,	,
cord-001835-0s7ok4uw	4742	33	3	3	CD
cord-001835-0s7ok4uw	4742	34	Department	Department	NNP
cord-001835-0s7ok4uw	4742	35	of	of	IN
cord-001835-0s7ok4uw	4742	36	Pharmacology	Pharmacology	NNP
cord-001835-0s7ok4uw	4742	37	,	,	,
cord-001835-0s7ok4uw	4742	38	Drug	Drug	NNP
cord-001835-0s7ok4uw	4742	39	Development	Development	NNP
cord-001835-0s7ok4uw	4742	40	and	and	CC
cord-001835-0s7ok4uw	4742	41	Therapeutics	Therapeutics	NNP
cord-001835-0s7ok4uw	4742	42	,	,	,
cord-001835-0s7ok4uw	4742	43	4	4	CD
cord-001835-0s7ok4uw	4742	44	 	 	_SP
cord-001835-0s7ok4uw	4742	45	Sialic	Sialic	NNP
cord-001835-0s7ok4uw	4742	46	acid	acid	NN
cord-001835-0s7ok4uw	4742	47	-	-	HYPH
cord-001835-0s7ok4uw	4742	48	binding	bind	VBG
cord-001835-0s7ok4uw	4742	49	immunoglobulin	immunoglobulin	NN
cord-001835-0s7ok4uw	4742	50	(	(	-LRB-
cord-001835-0s7ok4uw	4742	51	Ig)-like	ig)-like	IN
cord-001835-0s7ok4uw	4742	52	lectins	lectin	NNS
cord-001835-0s7ok4uw	4742	53	(	(	-LRB-
cord-001835-0s7ok4uw	4742	54	Siglec	Siglec	NNP
cord-001835-0s7ok4uw	4742	55	)	)	-RRB-
cord-001835-0s7ok4uw	4742	56	are	be	VBP
cord-001835-0s7ok4uw	4742	57	type	type	NN
cord-001835-0s7ok4uw	4742	58	I	-PRON-	PRP
cord-001835-0s7ok4uw	4742	59	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	4742	60	proteins	protein	NNS
cord-001835-0s7ok4uw	4742	61	.	.	.
cord-001835-0s7ok4uw	4743	1	Siglec-9	Siglec-9	NNP
cord-001835-0s7ok4uw	4743	2	has	have	VBZ
cord-001835-0s7ok4uw	4743	3	an	an	DT
cord-001835-0s7ok4uw	4743	4	N	n	CD
cord-001835-0s7ok4uw	4743	5	-	-	HYPH
cord-001835-0s7ok4uw	4743	6	terminal	terminal	NN
cord-001835-0s7ok4uw	4743	7	V	v	NN
cord-001835-0s7ok4uw	4743	8	-	-	HYPH
cord-001835-0s7ok4uw	4743	9	set	set	NN
cord-001835-0s7ok4uw	4743	10	domain	domain	NN
cord-001835-0s7ok4uw	4743	11	followed	follow	VBN
cord-001835-0s7ok4uw	4743	12	by	by	IN
cord-001835-0s7ok4uw	4743	13	two	two	CD
cord-001835-0s7ok4uw	4743	14	C2-set	c2-set	NN
cord-001835-0s7ok4uw	4743	15	domains	domain	NNS
cord-001835-0s7ok4uw	4743	16	in	in	IN
cord-001835-0s7ok4uw	4743	17	the	the	DT
cord-001835-0s7ok4uw	4743	18	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	4743	19	region	region	NN
cord-001835-0s7ok4uw	4743	20	.	.	.
cord-001835-0s7ok4uw	4744	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4744	2	contains	contain	VBZ
cord-001835-0s7ok4uw	4744	3	an	an	DT
cord-001835-0s7ok4uw	4744	4	immunoreceptor	immunoreceptor	JJ
cord-001835-0s7ok4uw	4744	5	tyrosinebased	tyrosinebase	VBN
cord-001835-0s7ok4uw	4744	6	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	4744	7	motif	motif	NN
cord-001835-0s7ok4uw	4744	8	(	(	-LRB-
cord-001835-0s7ok4uw	4744	9	ITIMs	ITIMs	NNP
cord-001835-0s7ok4uw	4744	10	)	)	-RRB-
cord-001835-0s7ok4uw	4744	11	in	in	IN
cord-001835-0s7ok4uw	4744	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4744	13	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	4744	14	tail	tail	NN
cord-001835-0s7ok4uw	4744	15	and	and	CC
cord-001835-0s7ok4uw	4744	16	can	can	MD
cord-001835-0s7ok4uw	4744	17	function	function	VB
cord-001835-0s7ok4uw	4744	18	as	as	IN
cord-001835-0s7ok4uw	4744	19	an	an	DT
cord-001835-0s7ok4uw	4744	20	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	4744	21	receptor	receptor	NN
cord-001835-0s7ok4uw	4744	22	by	by	IN
cord-001835-0s7ok4uw	4744	23	dampening	dampen	VBG
cord-001835-0s7ok4uw	4744	24	the	the	DT
cord-001835-0s7ok4uw	4744	25	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	4744	26	kinase	kinase	RB
cord-001835-0s7ok4uw	4744	27	-	-	HYPH
cord-001835-0s7ok4uw	4744	28	driven	drive	VBN
cord-001835-0s7ok4uw	4744	29	signaling	signal	VBG
cord-001835-0s7ok4uw	4744	30	pathways	pathway	NNS
cord-001835-0s7ok4uw	4744	31	.	.	.
cord-001835-0s7ok4uw	4745	1	These	these	DT
cord-001835-0s7ok4uw	4745	2	proteins	protein	NNS
cord-001835-0s7ok4uw	4745	3	are	be	VBP
cord-001835-0s7ok4uw	4745	4	expressed	express	VBN
cord-001835-0s7ok4uw	4745	5	primarily	primarily	RB
cord-001835-0s7ok4uw	4745	6	on	on	IN
cord-001835-0s7ok4uw	4745	7	leukocyte	leukocyte	NN
cord-001835-0s7ok4uw	4745	8	subsets	subset	NNS
cord-001835-0s7ok4uw	4745	9	and	and	CC
cord-001835-0s7ok4uw	4745	10	,	,	,
cord-001835-0s7ok4uw	4745	11	thus	thus	RB
cord-001835-0s7ok4uw	4745	12	,	,	,
cord-001835-0s7ok4uw	4745	13	are	be	VBP
cord-001835-0s7ok4uw	4745	14	thought	think	VBN
cord-001835-0s7ok4uw	4745	15	to	to	TO
cord-001835-0s7ok4uw	4745	16	be	be	VB
cord-001835-0s7ok4uw	4745	17	involved	involve	VBN
cord-001835-0s7ok4uw	4745	18	in	in	IN
cord-001835-0s7ok4uw	4745	19	regulation	regulation	NN
cord-001835-0s7ok4uw	4745	20	of	of	IN
cord-001835-0s7ok4uw	4745	21	leukocyte	leukocyte	NN
cord-001835-0s7ok4uw	4745	22	functions	function	NNS
cord-001835-0s7ok4uw	4745	23	during	during	IN
cord-001835-0s7ok4uw	4745	24	inflammatory	inflammatory	JJ
cord-001835-0s7ok4uw	4745	25	and	and	CC
cord-001835-0s7ok4uw	4745	26	immune	immune	JJ
cord-001835-0s7ok4uw	4745	27	responses	response	NNS
cord-001835-0s7ok4uw	4745	28	.	.	.
cord-001835-0s7ok4uw	4746	1	Recently	recently	RB
cord-001835-0s7ok4uw	4746	2	,	,	,
cord-001835-0s7ok4uw	4746	3	phage	phage	NN
cord-001835-0s7ok4uw	4746	4	display	display	NN
cord-001835-0s7ok4uw	4746	5	screening	screening	NN
cord-001835-0s7ok4uw	4746	6	experiments	experiment	NNS
cord-001835-0s7ok4uw	4746	7	identified	identify	VBD
cord-001835-0s7ok4uw	4746	8	Siglec-9	Siglec-9	NNP
cord-001835-0s7ok4uw	4746	9	as	as	IN
cord-001835-0s7ok4uw	4746	10	leukocyte	leukocyte	NN
cord-001835-0s7ok4uw	4746	11	surface	surface	NN
cord-001835-0s7ok4uw	4746	12	ligand	ligand	NN
cord-001835-0s7ok4uw	4746	13	for	for	IN
cord-001835-0s7ok4uw	4746	14	human	human	JJ
cord-001835-0s7ok4uw	4746	15	vascular	vascular	JJ
cord-001835-0s7ok4uw	4746	16	adhesion	adhesion	NN
cord-001835-0s7ok4uw	4746	17	protein	protein	NN
cord-001835-0s7ok4uw	4746	18	21	21	CD
cord-001835-0s7ok4uw	4746	19	(	(	-LRB-
cord-001835-0s7ok4uw	4746	20	hVAP-1	hvap-1	ADD
cord-001835-0s7ok4uw	4746	21	;	;	:
cord-001835-0s7ok4uw	4746	22	AOC3	AOC3	NNP
cord-001835-0s7ok4uw	4746	23	gene	gene	NN
cord-001835-0s7ok4uw	4746	24	product	product	NN
cord-001835-0s7ok4uw	4746	25	)	)	-RRB-
cord-001835-0s7ok4uw	4746	26	and	and	CC
cord-001835-0s7ok4uw	4746	27	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4746	28	interaction	interaction	NN
cord-001835-0s7ok4uw	4746	29	was	be	VBD
cord-001835-0s7ok4uw	4746	30	confirmed	confirm	VBN
cord-001835-0s7ok4uw	4746	31	by	by	IN
cord-001835-0s7ok4uw	4746	32	cell	cell	NN
cord-001835-0s7ok4uw	4746	33	adhesion	adhesion	NN
cord-001835-0s7ok4uw	4746	34	and	and	CC
cord-001835-0s7ok4uw	4746	35	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	4746	36	assays	assay	NNS
cord-001835-0s7ok4uw	4747	1	(	(	-LRB-
cord-001835-0s7ok4uw	4747	2	Kivi	Kivi	NNP
cord-001835-0s7ok4uw	4747	3	et	et	NNP
cord-001835-0s7ok4uw	4747	4	al	al	NNP
cord-001835-0s7ok4uw	4747	5	.	.	.
cord-001835-0s7ok4uw	4748	1	,	,	,
cord-001835-0s7ok4uw	4748	2	2009	2009	CD
cord-001835-0s7ok4uw	4748	3	;	;	:
cord-001835-0s7ok4uw	4748	4	Aalto	Aalto	NNP
cord-001835-0s7ok4uw	4748	5	et	et	NNP
cord-001835-0s7ok4uw	4748	6	al	al	NNP
cord-001835-0s7ok4uw	4748	7	.	.	NNP
cord-001835-0s7ok4uw	4748	8	,	,	,
cord-001835-0s7ok4uw	4748	9	2011	2011	CD
cord-001835-0s7ok4uw	4748	10	)	)	-RRB-
cord-001835-0s7ok4uw	4748	11	.	.	.
cord-001835-0s7ok4uw	4749	1	Based	base	VBN
cord-001835-0s7ok4uw	4749	2	on	on	IN
cord-001835-0s7ok4uw	4749	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4749	4	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	4749	5	data	datum	NNS
cord-001835-0s7ok4uw	4749	6	,	,	,
cord-001835-0s7ok4uw	4749	7	hVAP-1	hvap-1	ADD
cord-001835-0s7ok4uw	4749	8	sugar	sugar	NN
cord-001835-0s7ok4uw	4749	9	units	unit	NNS
cord-001835-0s7ok4uw	4749	10	with	with	IN
cord-001835-0s7ok4uw	4749	11	sialic	sialic	JJ
cord-001835-0s7ok4uw	4749	12	acid	acid	NN
cord-001835-0s7ok4uw	4749	13	(	(	-LRB-
cord-001835-0s7ok4uw	4749	14	SA	sa	NN
cord-001835-0s7ok4uw	4749	15	)	)	-RRB-
cord-001835-0s7ok4uw	4749	16	might	may	MD
cord-001835-0s7ok4uw	4749	17	mediate	mediate	VB
cord-001835-0s7ok4uw	4749	18	interactions	interaction	NNS
cord-001835-0s7ok4uw	4749	19	with	with	IN
cord-001835-0s7ok4uw	4749	20	the	the	DT
cord-001835-0s7ok4uw	4749	21	V	v	NN
cord-001835-0s7ok4uw	4749	22	-	-	HYPH
cord-001835-0s7ok4uw	4749	23	set	set	NN
cord-001835-0s7ok4uw	4749	24	domain	domain	NN
cord-001835-0s7ok4uw	4749	25	in	in	IN
cord-001835-0s7ok4uw	4749	26	Siglec-9	Siglec-9	NNP
cord-001835-0s7ok4uw	4749	27	.	.	.
cord-001835-0s7ok4uw	4750	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	4750	2	,	,	,
cord-001835-0s7ok4uw	4750	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	4750	4	is	be	VBZ
cord-001835-0s7ok4uw	4750	5	known	know	VBN
cord-001835-0s7ok4uw	4750	6	that	that	IN
cord-001835-0s7ok4uw	4750	7	the	the	DT
cord-001835-0s7ok4uw	4750	8	Siglec	Siglec	NNP
cord-001835-0s7ok4uw	4750	9	peptides	peptide	NNS
cord-001835-0s7ok4uw	4750	10	binding	bind	VBG
cord-001835-0s7ok4uw	4750	11	to	to	IN
cord-001835-0s7ok4uw	4750	12	hVAP-1	hvap-1	ADD
cord-001835-0s7ok4uw	4750	13	are	be	VBP
cord-001835-0s7ok4uw	4750	14	located	locate	VBN
cord-001835-0s7ok4uw	4750	15	in	in	IN
cord-001835-0s7ok4uw	4750	16	the	the	DT
cord-001835-0s7ok4uw	4750	17	CE	CE	NNP
cord-001835-0s7ok4uw	4750	18	loop	loop	NN
cord-001835-0s7ok4uw	4750	19	of	of	IN
cord-001835-0s7ok4uw	4750	20	the	the	DT
cord-001835-0s7ok4uw	4750	21	second	second	JJ
cord-001835-0s7ok4uw	4750	22	C22-set	C22-set	NNP
cord-001835-0s7ok4uw	4750	23	of	of	IN
cord-001835-0s7ok4uw	4750	24	domain	domain	NN
cord-001835-0s7ok4uw	4750	25	(	(	-LRB-
cord-001835-0s7ok4uw	4750	26	Siglec-9_C22	Siglec-9_C22	NNP
cord-001835-0s7ok4uw	4750	27	)	)	-RRB-
cord-001835-0s7ok4uw	4750	28	.	.	.
cord-001835-0s7ok4uw	4751	1	Based	base	VBN
cord-001835-0s7ok4uw	4751	2	on	on	IN
cord-001835-0s7ok4uw	4751	3	current	current	JJ
cord-001835-0s7ok4uw	4751	4	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	4751	5	an	an	DT
cord-001835-0s7ok4uw	4751	6	arginine	arginine	NN
cord-001835-0s7ok4uw	4751	7	in	in	IN
cord-001835-0s7ok4uw	4751	8	Siglec-9_C22	Siglec-9_C22	NNP
cord-001835-0s7ok4uw	4751	9	interacts	interact	VBZ
cord-001835-0s7ok4uw	4751	10	with	with	IN
cord-001835-0s7ok4uw	4751	11	the	the	DT
cord-001835-0s7ok4uw	4751	12	TPQ	TPQ	NNP
cord-001835-0s7ok4uw	4751	13	residue	residue	NN
cord-001835-0s7ok4uw	4751	14	in	in	IN
cord-001835-0s7ok4uw	4751	15	the	the	DT
cord-001835-0s7ok4uw	4751	16	active	active	JJ
cord-001835-0s7ok4uw	4751	17	site	site	NN
cord-001835-0s7ok4uw	4751	18	of	of	IN
cord-001835-0s7ok4uw	4751	19	hVAP-1	hvap-1	ADD
cord-001835-0s7ok4uw	4751	20	.	.	.
cord-001835-0s7ok4uw	4752	1	The	the	DT
cord-001835-0s7ok4uw	4752	2	CE	CE	NNP
cord-001835-0s7ok4uw	4752	3	loop	loop	NN
cord-001835-0s7ok4uw	4752	4	of	of	IN
cord-001835-0s7ok4uw	4752	5	Siglec-9_C22	Siglec-9_C22	NNP
cord-001835-0s7ok4uw	4752	6	has	have	VBZ
cord-001835-0s7ok4uw	4752	7	two	two	CD
cord-001835-0s7ok4uw	4752	8	arginines	arginine	NNS
cord-001835-0s7ok4uw	4752	9	(	(	-LRB-
cord-001835-0s7ok4uw	4752	10	R284	R284	NNP
cord-001835-0s7ok4uw	4752	11	and	and	CC
cord-001835-0s7ok4uw	4752	12	R290	R290	NNPS
cord-001835-0s7ok4uw	4752	13	)	)	-RRB-
cord-001835-0s7ok4uw	4752	14	and	and	CC
cord-001835-0s7ok4uw	4752	15	,	,	,
cord-001835-0s7ok4uw	4752	16	therefore	therefore	RB
cord-001835-0s7ok4uw	4752	17	,	,	,
cord-001835-0s7ok4uw	4752	18	the	the	DT
cord-001835-0s7ok4uw	4752	19	interacting	interact	VBG
cord-001835-0s7ok4uw	4752	20	arginine	arginine	NN
cord-001835-0s7ok4uw	4752	21	is	be	VBZ
cord-001835-0s7ok4uw	4752	22	unclear	unclear	JJ
cord-001835-0s7ok4uw	4752	23	.	.	.
cord-001835-0s7ok4uw	4753	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4753	2	will	will	MD
cord-001835-0s7ok4uw	4753	3	now	now	RB
cord-001835-0s7ok4uw	4753	4	study	study	VB
cord-001835-0s7ok4uw	4753	5	the	the	DT
cord-001835-0s7ok4uw	4753	6	interaction	interaction	NN
cord-001835-0s7ok4uw	4753	7	mode	mode	NN
cord-001835-0s7ok4uw	4753	8	of	of	IN
cord-001835-0s7ok4uw	4753	9	hVAP-1	hvap-1	ADD
cord-001835-0s7ok4uw	4753	10	and	and	CC
cord-001835-0s7ok4uw	4753	11	Siglec-9	Siglec-9	NNPS
cord-001835-0s7ok4uw	4753	12	in	in	IN
cord-001835-0s7ok4uw	4753	13	silico	silico	NN
cord-001835-0s7ok4uw	4753	14	to	to	TO
cord-001835-0s7ok4uw	4753	15	predict	predict	VB
cord-001835-0s7ok4uw	4753	16	the	the	DT
cord-001835-0s7ok4uw	4753	17	role	role	NN
cord-001835-0s7ok4uw	4753	18	of	of	IN
cord-001835-0s7ok4uw	4753	19	the	the	DT
cord-001835-0s7ok4uw	4753	20	arginines	arginine	NNS
cord-001835-0s7ok4uw	4753	21	in	in	IN
cord-001835-0s7ok4uw	4753	22	the	the	DT
cord-001835-0s7ok4uw	4753	23	C22	C22	NNP
cord-001835-0s7ok4uw	4753	24	domain	domain	NN
cord-001835-0s7ok4uw	4753	25	and	and	CC
cord-001835-0s7ok4uw	4753	26	the	the	DT
cord-001835-0s7ok4uw	4753	27	role	role	NN
cord-001835-0s7ok4uw	4753	28	of	of	IN
cord-001835-0s7ok4uw	4753	29	SA	sa	NN
cord-001835-0s7ok4uw	4753	30	-	-	HYPH
cord-001835-0s7ok4uw	4753	31	binding	bind	VBG
cord-001835-0s7ok4uw	4753	32	using	use	VBG
cord-001835-0s7ok4uw	4753	33	the	the	DT
cord-001835-0s7ok4uw	4753	34	3D	3d	JJ
cord-001835-0s7ok4uw	4753	35	model	model	NN
cord-001835-0s7ok4uw	4753	36	of	of	IN
cord-001835-0s7ok4uw	4753	37	the	the	DT
cord-001835-0s7ok4uw	4753	38	full	full	JJ
cord-001835-0s7ok4uw	4753	39	-	-	HYPH
cord-001835-0s7ok4uw	4753	40	length	length	NN
cord-001835-0s7ok4uw	4753	41	ectodomain	ectodomain	NN
cord-001835-0s7ok4uw	4753	42	of	of	IN
cord-001835-0s7ok4uw	4753	43	Siglec-9	Siglec-9	NNP
cord-001835-0s7ok4uw	4753	44	and	and	CC
cord-001835-0s7ok4uw	4753	45	the	the	DT
cord-001835-0s7ok4uw	4753	46	hVAP-1	hvap-1	ADD
cord-001835-0s7ok4uw	4753	47	crystal	crystal	NN
cord-001835-0s7ok4uw	4753	48	structure	structure	NN
cord-001835-0s7ok4uw	4753	49	.	.	.
cord-001835-0s7ok4uw	4754	1	The	the	DT
cord-001835-0s7ok4uw	4754	2	in	in	IN
cord-001835-0s7ok4uw	4754	3	silico	silico	NN
cord-001835-0s7ok4uw	4754	4	analysis	analysis	NN
cord-001835-0s7ok4uw	4754	5	will	will	MD
cord-001835-0s7ok4uw	4754	6	be	be	VB
cord-001835-0s7ok4uw	4754	7	conducted	conduct	VBN
cord-001835-0s7ok4uw	4754	8	in	in	IN
cord-001835-0s7ok4uw	4754	9	parallel	parallel	NN
cord-001835-0s7ok4uw	4754	10	with	with	IN
cord-001835-0s7ok4uw	4754	11	experimental	experimental	JJ
cord-001835-0s7ok4uw	4754	12	site	site	NN
cord-001835-0s7ok4uw	4754	13	-	-	HYPH
cord-001835-0s7ok4uw	4754	14	specific	specific	JJ
cord-001835-0s7ok4uw	4754	15	mutational	mutational	JJ
cord-001835-0s7ok4uw	4754	16	studies	study	NNS
cord-001835-0s7ok4uw	4754	17	and	and	CC
cord-001835-0s7ok4uw	4754	18	the	the	DT
cord-001835-0s7ok4uw	4754	19	result	result	NN
cord-001835-0s7ok4uw	4754	20	will	will	MD
cord-001835-0s7ok4uw	4754	21	be	be	VB
cord-001835-0s7ok4uw	4754	22	combined	combine	VBN
cord-001835-0s7ok4uw	4754	23	to	to	TO
cord-001835-0s7ok4uw	4754	24	elucidate	elucidate	VB
cord-001835-0s7ok4uw	4754	25	the	the	DT
cord-001835-0s7ok4uw	4754	26	mechanism	mechanism	NN
cord-001835-0s7ok4uw	4754	27	of	of	IN
cord-001835-0s7ok4uw	4754	28	hVAP-1-Siglec-9	hvap-1-siglec-9	NN
cord-001835-0s7ok4uw	4754	29	interaction	interaction	NN
cord-001835-0s7ok4uw	4754	30	.	.	.
cord-001835-0s7ok4uw	4755	1	Adam	Adam	NNP
cord-001835-0s7ok4uw	4755	2	Middleton	Middleton	NNP
cord-001835-0s7ok4uw	4755	3	1	1	CD
cord-001835-0s7ok4uw	4755	4	,	,	,
cord-001835-0s7ok4uw	4755	5	Catherine	Catherine	NNP
cord-001835-0s7ok4uw	4755	6	Day	Day	NNP
cord-001835-0s7ok4uw	4755	7	1	1	CD
cord-001835-0s7ok4uw	4755	8	1	1	CD
cord-001835-0s7ok4uw	4755	9	Attachment	attachment	NN
cord-001835-0s7ok4uw	4755	10	of	of	IN
cord-001835-0s7ok4uw	4755	11	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4755	12	to	to	IN
cord-001835-0s7ok4uw	4755	13	substrate	substrate	NN
cord-001835-0s7ok4uw	4755	14	proteins	protein	NNS
cord-001835-0s7ok4uw	4755	15	regulates	regulate	VBZ
cord-001835-0s7ok4uw	4755	16	almost	almost	RB
cord-001835-0s7ok4uw	4755	17	all	all	DT
cord-001835-0s7ok4uw	4755	18	cellular	cellular	JJ
cord-001835-0s7ok4uw	4755	19	processes	process	NNS
cord-001835-0s7ok4uw	4755	20	,	,	,
cord-001835-0s7ok4uw	4755	21	including	include	VBG
cord-001835-0s7ok4uw	4755	22	protein	protein	NN
cord-001835-0s7ok4uw	4755	23	degradation	degradation	NN
cord-001835-0s7ok4uw	4755	24	and	and	CC
cord-001835-0s7ok4uw	4755	25	cell	cell	NN
cord-001835-0s7ok4uw	4755	26	division	division	NN
cord-001835-0s7ok4uw	4755	27	.	.	.
cord-001835-0s7ok4uw	4756	1	Ubiquitylation	Ubiquitylation	NNP
cord-001835-0s7ok4uw	4756	2	involves	involve	VBZ
cord-001835-0s7ok4uw	4756	3	a	a	DT
cord-001835-0s7ok4uw	4756	4	cascade	cascade	NN
cord-001835-0s7ok4uw	4756	5	of	of	IN
cord-001835-0s7ok4uw	4756	6	three	three	CD
cord-001835-0s7ok4uw	4756	7	families	family	NNS
cord-001835-0s7ok4uw	4756	8	of	of	IN
cord-001835-0s7ok4uw	4756	9	proteins	protein	NNS
cord-001835-0s7ok4uw	4756	10	:	:	:
cord-001835-0s7ok4uw	4756	11	ubiquitin	ubiquitin	NNP
cord-001835-0s7ok4uw	4756	12	activating	activate	VBG
cord-001835-0s7ok4uw	4756	13	(	(	-LRB-
cord-001835-0s7ok4uw	4756	14	E1	E1	NNP
cord-001835-0s7ok4uw	4756	15	)	)	-RRB-
cord-001835-0s7ok4uw	4756	16	,	,	,
cord-001835-0s7ok4uw	4756	17	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4756	18	conjugating	conjugate	VBG
cord-001835-0s7ok4uw	4756	19	(	(	-LRB-
cord-001835-0s7ok4uw	4756	20	E2	E2	NNP
cord-001835-0s7ok4uw	4756	21	)	)	-RRB-
cord-001835-0s7ok4uw	4756	22	and	and	CC
cord-001835-0s7ok4uw	4756	23	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4756	24	ligase	ligase	NN
cord-001835-0s7ok4uw	4756	25	(	(	-LRB-
cord-001835-0s7ok4uw	4756	26	E3	E3	NNP
cord-001835-0s7ok4uw	4756	27	)	)	-RRB-
cord-001835-0s7ok4uw	4756	28	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4756	29	.	.	.
cord-001835-0s7ok4uw	4757	1	The	the	DT
cord-001835-0s7ok4uw	4757	2	8.5	8.5	CD
cord-001835-0s7ok4uw	4757	3	kDa	kDa	NNP
cord-001835-0s7ok4uw	4757	4	protein	protein	NN
cord-001835-0s7ok4uw	4757	5	can	can	MD
cord-001835-0s7ok4uw	4757	6	be	be	VB
cord-001835-0s7ok4uw	4757	7	attached	attach	VBN
cord-001835-0s7ok4uw	4757	8	as	as	IN
cord-001835-0s7ok4uw	4757	9	a	a	DT
cord-001835-0s7ok4uw	4757	10	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	4757	11	moiety	moiety	NN
cord-001835-0s7ok4uw	4757	12	or	or	CC
cord-001835-0s7ok4uw	4757	13	as	as	IN
cord-001835-0s7ok4uw	4757	14	a	a	DT
cord-001835-0s7ok4uw	4757	15	polyubiquitin	polyubiquitin	NNP
cord-001835-0s7ok4uw	4757	16	chain	chain	NN
cord-001835-0s7ok4uw	4757	17	,	,	,
cord-001835-0s7ok4uw	4757	18	and	and	CC
cord-001835-0s7ok4uw	4757	19	the	the	DT
cord-001835-0s7ok4uw	4757	20	type	type	NN
cord-001835-0s7ok4uw	4757	21	of	of	IN
cord-001835-0s7ok4uw	4757	22	modification	modification	NN
cord-001835-0s7ok4uw	4757	23	spells	spell	VBZ
cord-001835-0s7ok4uw	4757	24	out	out	RP
cord-001835-0s7ok4uw	4757	25	the	the	DT
cord-001835-0s7ok4uw	4757	26	'	'	``
cord-001835-0s7ok4uw	4757	27	ubiquitin	ubiquitin	JJ
cord-001835-0s7ok4uw	4757	28	code	code	NN
cord-001835-0s7ok4uw	4757	29	'	'	''
cord-001835-0s7ok4uw	4757	30	that	that	WDT
cord-001835-0s7ok4uw	4757	31	directs	direct	VBZ
cord-001835-0s7ok4uw	4757	32	the	the	DT
cord-001835-0s7ok4uw	4757	33	fate	fate	NN
cord-001835-0s7ok4uw	4757	34	of	of	IN
cord-001835-0s7ok4uw	4757	35	the	the	DT
cord-001835-0s7ok4uw	4757	36	substrate	substrate	NN
cord-001835-0s7ok4uw	4757	37	.	.	.
cord-001835-0s7ok4uw	4758	1	Polyubiquitin	Polyubiquitin	NNP
cord-001835-0s7ok4uw	4758	2	chains	chain	NNS
cord-001835-0s7ok4uw	4758	3	can	can	MD
cord-001835-0s7ok4uw	4758	4	be	be	VB
cord-001835-0s7ok4uw	4758	5	formed	form	VBN
cord-001835-0s7ok4uw	4758	6	via	via	IN
cord-001835-0s7ok4uw	4758	7	eight	eight	CD
cord-001835-0s7ok4uw	4758	8	different	different	JJ
cord-001835-0s7ok4uw	4758	9	linkage	linkage	NN
cord-001835-0s7ok4uw	4758	10	types	type	NNS
cord-001835-0s7ok4uw	4758	11	,	,	,
cord-001835-0s7ok4uw	4758	12	and	and	CC
cord-001835-0s7ok4uw	4758	13	the	the	DT
cord-001835-0s7ok4uw	4758	14	arrangement	arrangement	NN
cord-001835-0s7ok4uw	4758	15	of	of	IN
cord-001835-0s7ok4uw	4758	16	chain	chain	NN
cord-001835-0s7ok4uw	4758	17	formation	formation	NN
cord-001835-0s7ok4uw	4758	18	is	be	VBZ
cord-001835-0s7ok4uw	4758	19	typically	typically	RB
cord-001835-0s7ok4uw	4758	20	directed	direct	VBN
cord-001835-0s7ok4uw	4758	21	by	by	IN
cord-001835-0s7ok4uw	4758	22	the	the	DT
cord-001835-0s7ok4uw	4758	23	E2	E2	NNP
cord-001835-0s7ok4uw	4758	24	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4758	25	.	.	.
cord-001835-0s7ok4uw	4759	1	Forming	form	VBG
cord-001835-0s7ok4uw	4759	2	a	a	DT
cord-001835-0s7ok4uw	4759	3	polyubiquitin	polyubiquitin	NNS
cord-001835-0s7ok4uw	4759	4	chain	chain	NN
cord-001835-0s7ok4uw	4759	5	involves	involve	VBZ
cord-001835-0s7ok4uw	4759	6	binding	bind	VBG
cord-001835-0s7ok4uw	4759	7	of	of	IN
cord-001835-0s7ok4uw	4759	8	two	two	CD
cord-001835-0s7ok4uw	4759	9	molecules	molecule	NNS
cord-001835-0s7ok4uw	4759	10	to	to	IN
cord-001835-0s7ok4uw	4759	11	the	the	DT
cord-001835-0s7ok4uw	4759	12	E2	E2	NNP
cord-001835-0s7ok4uw	4759	13	:	:	:
cord-001835-0s7ok4uw	4759	14	the	the	DT
cord-001835-0s7ok4uw	4759	15	donor	donor	NN
cord-001835-0s7ok4uw	4759	16	(	(	-LRB-
cord-001835-0s7ok4uw	4759	17	UbD	UbD	NNP
cord-001835-0s7ok4uw	4759	18	)	)	-RRB-
cord-001835-0s7ok4uw	4759	19	and	and	CC
cord-001835-0s7ok4uw	4760	1	acceptor	acceptor	NNP
cord-001835-0s7ok4uw	4760	2	(	(	-LRB-
cord-001835-0s7ok4uw	4760	3	UbA	uba	NN
cord-001835-0s7ok4uw	4760	4	)	)	-RRB-
cord-001835-0s7ok4uw	4760	5	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4760	6	.	.	.
cord-001835-0s7ok4uw	4761	1	UbD	UbD	NNP
cord-001835-0s7ok4uw	4761	2	is	be	VBZ
cord-001835-0s7ok4uw	4761	3	linked	link	VBN
cord-001835-0s7ok4uw	4761	4	to	to	IN
cord-001835-0s7ok4uw	4761	5	the	the	DT
cord-001835-0s7ok4uw	4761	6	E2	E2	NNP
cord-001835-0s7ok4uw	4761	7	via	via	IN
cord-001835-0s7ok4uw	4761	8	a	a	DT
cord-001835-0s7ok4uw	4761	9	thioester	thioester	NN
cord-001835-0s7ok4uw	4761	10	bond	bond	NN
cord-001835-0s7ok4uw	4761	11	between	between	IN
cord-001835-0s7ok4uw	4761	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4761	13	C	c	NN
cord-001835-0s7ok4uw	4761	14	-	-	HYPH
cord-001835-0s7ok4uw	4761	15	terminal	terminal	NN
cord-001835-0s7ok4uw	4761	16	Gly	Gly	NNP
cord-001835-0s7ok4uw	4761	17	and	and	CC
cord-001835-0s7ok4uw	4761	18	the	the	DT
cord-001835-0s7ok4uw	4761	19	active	active	JJ
cord-001835-0s7ok4uw	4761	20	site	site	NN
cord-001835-0s7ok4uw	4761	21	Cys	Cys	NNP
cord-001835-0s7ok4uw	4761	22	of	of	IN
cord-001835-0s7ok4uw	4761	23	the	the	DT
cord-001835-0s7ok4uw	4761	24	E2	E2	NNP
cord-001835-0s7ok4uw	4761	25	,	,	,
cord-001835-0s7ok4uw	4761	26	and	and	CC
cord-001835-0s7ok4uw	4761	27	when	when	WRB
cord-001835-0s7ok4uw	4761	28	primed	prime	VBN
cord-001835-0s7ok4uw	4761	29	for	for	IN
cord-001835-0s7ok4uw	4761	30	catalysis	catalysis	NN
cord-001835-0s7ok4uw	4761	31	it	-PRON-	PRP
cord-001835-0s7ok4uw	4761	32	interacts	interact	VBZ
cord-001835-0s7ok4uw	4761	33	with	with	IN
cord-001835-0s7ok4uw	4761	34	a	a	DT
cord-001835-0s7ok4uw	4761	35	particular	particular	JJ
cord-001835-0s7ok4uw	4761	36	face	face	NN
cord-001835-0s7ok4uw	4761	37	of	of	IN
cord-001835-0s7ok4uw	4761	38	the	the	DT
cord-001835-0s7ok4uw	4761	39	E2	E2	NNP
cord-001835-0s7ok4uw	4761	40	.	.	.
cord-001835-0s7ok4uw	4762	1	In	in	IN
cord-001835-0s7ok4uw	4762	2	contrast	contrast	NN
cord-001835-0s7ok4uw	4762	3	,	,	,
cord-001835-0s7ok4uw	4762	4	coordination	coordination	NN
cord-001835-0s7ok4uw	4762	5	of	of	IN
cord-001835-0s7ok4uw	4762	6	UbA	uba	NN
cord-001835-0s7ok4uw	4762	7	by	by	IN
cord-001835-0s7ok4uw	4762	8	E2s	E2s	NNP
cord-001835-0s7ok4uw	4762	9	is	be	VBZ
cord-001835-0s7ok4uw	4762	10	transient	transient	JJ
cord-001835-0s7ok4uw	4762	11	and	and	CC
cord-001835-0s7ok4uw	4762	12	can	can	MD
cord-001835-0s7ok4uw	4762	13	not	not	RB
cord-001835-0s7ok4uw	4762	14	be	be	VB
cord-001835-0s7ok4uw	4762	15	easily	easily	RB
cord-001835-0s7ok4uw	4762	16	measured	measure	VBN
cord-001835-0s7ok4uw	4762	17	;	;	:
cord-001835-0s7ok4uw	4762	18	however	however	RB
cord-001835-0s7ok4uw	4762	19	,	,	,
cord-001835-0s7ok4uw	4762	20	UbA	uba	NN
cord-001835-0s7ok4uw	4762	21	binding	binding	NN
cord-001835-0s7ok4uw	4762	22	defines	define	VBZ
cord-001835-0s7ok4uw	4762	23	the	the	DT
cord-001835-0s7ok4uw	4762	24	linkage	linkage	NN
cord-001835-0s7ok4uw	4762	25	type	type	NN
cord-001835-0s7ok4uw	4762	26	of	of	IN
cord-001835-0s7ok4uw	4762	27	polyubiquitin	polyubiquitin	NNP
cord-001835-0s7ok4uw	4762	28	chains	chain	NNS
cord-001835-0s7ok4uw	4762	29	.	.	.
cord-001835-0s7ok4uw	4763	1	The	the	DT
cord-001835-0s7ok4uw	4763	2	E2	E2	NNP
cord-001835-0s7ok4uw	4763	3	,	,	,
cord-001835-0s7ok4uw	4763	4	Ube2	Ube2	NNP
cord-001835-0s7ok4uw	4763	5	K	K	NNP
cord-001835-0s7ok4uw	4763	6	,	,	,
cord-001835-0s7ok4uw	4763	7	directs	direct	VBZ
cord-001835-0s7ok4uw	4763	8	Lys48	Lys48	NNP
cord-001835-0s7ok4uw	4763	9	chain	chain	NN
cord-001835-0s7ok4uw	4763	10	synthesis	synthesis	NN
cord-001835-0s7ok4uw	4763	11	,	,	,
cord-001835-0s7ok4uw	4763	12	which	which	WDT
cord-001835-0s7ok4uw	4763	13	results	result	VBZ
cord-001835-0s7ok4uw	4763	14	in	in	IN
cord-001835-0s7ok4uw	4763	15	modified	modify	VBN
cord-001835-0s7ok4uw	4763	16	proteins	protein	NNS
cord-001835-0s7ok4uw	4763	17	being	be	VBG
cord-001835-0s7ok4uw	4763	18	degraded	degrade	VBN
cord-001835-0s7ok4uw	4763	19	by	by	IN
cord-001835-0s7ok4uw	4763	20	the	the	DT
cord-001835-0s7ok4uw	4763	21	proteasome	proteasome	NN
cord-001835-0s7ok4uw	4763	22	.	.	.
cord-001835-0s7ok4uw	4764	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4764	2	generated	generate	VBD
cord-001835-0s7ok4uw	4764	3	a	a	DT
cord-001835-0s7ok4uw	4764	4	stable	stable	JJ
cord-001835-0s7ok4uw	4764	5	form	form	NN
cord-001835-0s7ok4uw	4764	6	of	of	IN
cord-001835-0s7ok4uw	4764	7	the	the	DT
cord-001835-0s7ok4uw	4764	8	Ube2KUb	Ube2KUb	NNP
cord-001835-0s7ok4uw	4764	9	conjugate	conjugate	NN
cord-001835-0s7ok4uw	4764	10	and	and	CC
cord-001835-0s7ok4uw	4764	11	crystallized	crystallize	VBD
cord-001835-0s7ok4uw	4764	12	it	-PRON-	PRP
cord-001835-0s7ok4uw	4764	13	,	,	,
cord-001835-0s7ok4uw	4764	14	and	and	CC
cord-001835-0s7ok4uw	4764	15	showed	show	VBD
cord-001835-0s7ok4uw	4764	16	that	that	IN
cord-001835-0s7ok4uw	4764	17	both	both	DT
cord-001835-0s7ok4uw	4764	18	Ube2	Ube2	NNP
cord-001835-0s7ok4uw	4764	19	K	K	NNP
cord-001835-0s7ok4uw	4764	20	and	and	CC
cord-001835-0s7ok4uw	4764	21	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4764	22	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4764	23	conjugate	conjugate	NN
cord-001835-0s7ok4uw	4764	24	are	be	VBP
cord-001835-0s7ok4uw	4764	25	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	4764	26	.	.	.
cord-001835-0s7ok4uw	4765	1	Using	use	VBG
cord-001835-0s7ok4uw	4765	2	molecular	molecular	JJ
cord-001835-0s7ok4uw	4765	3	docking	docking	NN
cord-001835-0s7ok4uw	4765	4	,	,	,
cord-001835-0s7ok4uw	4765	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4765	6	modelled	model	VBD
cord-001835-0s7ok4uw	4765	7	the	the	DT
cord-001835-0s7ok4uw	4765	8	position	position	NN
cord-001835-0s7ok4uw	4765	9	of	of	IN
cord-001835-0s7ok4uw	4765	10	both	both	DT
cord-001835-0s7ok4uw	4765	11	UbD	UbD	NNS
cord-001835-0s7ok4uw	4765	12	and	and	CC
cord-001835-0s7ok4uw	4765	13	UbA	uba	NN
cord-001835-0s7ok4uw	4765	14	and	and	CC
cord-001835-0s7ok4uw	4765	15	investigated	investigate	VBD
cord-001835-0s7ok4uw	4765	16	the	the	DT
cord-001835-0s7ok4uw	4765	17	interfaces	interface	NNS
cord-001835-0s7ok4uw	4765	18	with	with	IN
cord-001835-0s7ok4uw	4765	19	site	site	NN
cord-001835-0s7ok4uw	4765	20	-	-	HYPH
cord-001835-0s7ok4uw	4765	21	directed	direct	VBN
cord-001835-0s7ok4uw	4765	22	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	4765	23	.	.	.
cord-001835-0s7ok4uw	4766	1	These	these	DT
cord-001835-0s7ok4uw	4766	2	experiments	experiment	NNS
cord-001835-0s7ok4uw	4766	3	led	lead	VBD
cord-001835-0s7ok4uw	4766	4	to	to	IN
cord-001835-0s7ok4uw	4766	5	a	a	DT
cord-001835-0s7ok4uw	4766	6	molecular	molecular	JJ
cord-001835-0s7ok4uw	4766	7	model	model	NN
cord-001835-0s7ok4uw	4766	8	that	that	WDT
cord-001835-0s7ok4uw	4766	9	revealed	reveal	VBD
cord-001835-0s7ok4uw	4766	10	how	how	WRB
cord-001835-0s7ok4uw	4766	11	Ube2	Ube2	NNP
cord-001835-0s7ok4uw	4766	12	K	K	NNP
cord-001835-0s7ok4uw	4766	13	can	can	MD
cord-001835-0s7ok4uw	4766	14	synthesise	synthesise	VB
cord-001835-0s7ok4uw	4766	15	Lys48-linked	lys48-linke	VBN
cord-001835-0s7ok4uw	4766	16	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4766	17	chains	chain	NNS
cord-001835-0s7ok4uw	4766	18	.	.	.
cord-001835-0s7ok4uw	4767	1	This	this	DT
cord-001835-0s7ok4uw	4767	2	molecular	molecular	JJ
cord-001835-0s7ok4uw	4767	3	explanation	explanation	NN
cord-001835-0s7ok4uw	4767	4	provides	provide	VBZ
cord-001835-0s7ok4uw	4767	5	a	a	DT
cord-001835-0s7ok4uw	4767	6	foundation	foundation	NN
cord-001835-0s7ok4uw	4767	7	for	for	IN
cord-001835-0s7ok4uw	4767	8	understanding	understand	VBG
cord-001835-0s7ok4uw	4767	9	how	how	WRB
cord-001835-0s7ok4uw	4767	10	other	other	JJ
cord-001835-0s7ok4uw	4767	11	E2s	E2s	NNP
cord-001835-0s7ok4uw	4767	12	generate	generate	VBP
cord-001835-0s7ok4uw	4767	13	Lys48-linked	lys48-linke	VBN
cord-001835-0s7ok4uw	4767	14	polyubiquitin	polyubiquitin	NNP
cord-001835-0s7ok4uw	4767	15	chains	chain	NNS
cord-001835-0s7ok4uw	4767	16	.	.	.
cord-001835-0s7ok4uw	4768	1	The	the	DT
cord-001835-0s7ok4uw	4768	2	two	two	CD
cord-001835-0s7ok4uw	4768	3	chromophorylated	chromophorylate	VBN
cord-001835-0s7ok4uw	4768	4	linkers	linker	NNS
cord-001835-0s7ok4uw	4768	5	of	of	IN
cord-001835-0s7ok4uw	4768	6	R	r	NN
cord-001835-0s7ok4uw	4768	7	-	-	HYPH
cord-001835-0s7ok4uw	4768	8	Phycoerythrin	Phycoerythrin	NNP
cord-001835-0s7ok4uw	4768	9	in	in	IN
cord-001835-0s7ok4uw	4768	10	Gracilaria	Gracilaria	NNP
cord-001835-0s7ok4uw	4768	11	chilensis	chilensis	NN
cord-001835-0s7ok4uw	4768	12	Marta	Marta	NNP
cord-001835-0s7ok4uw	4768	13	Bunster	Bunster	NNP
cord-001835-0s7ok4uw	4768	14	,	,	,
cord-001835-0s7ok4uw	4768	15	Francisco	Francisco	NNP
cord-001835-0s7ok4uw	4768	16	Lobos	Lobos	NNP
cord-001835-0s7ok4uw	4768	17	-	-	HYPH
cord-001835-0s7ok4uw	4768	18	Gonz	Gonz	NNP
cord-001835-0s7ok4uw	4768	19	alez	alez	NN
cord-001835-0s7ok4uw	4768	20	,	,	,
cord-001835-0s7ok4uw	4768	21	Jos	Jos	NNP
cord-001835-0s7ok4uw	4768	22	e	e	NNP
cord-001835-0s7ok4uw	4768	23	Aleikar	Aleikar	NNP
cord-001835-0s7ok4uw	4768	24	V	V	NNP
cord-001835-0s7ok4uw	4768	25	asquez	asquez	NNP
cord-001835-0s7ok4uw	4768	26	,	,	,
cord-001835-0s7ok4uw	4768	27	Carola	Carola	NNP
cord-001835-0s7ok4uw	4768	28	Bruna	Bruna	NNP
cord-001835-0s7ok4uw	4768	29	,	,	,
cord-001835-0s7ok4uw	4769	1	Jos	Jos	NNP
cord-001835-0s7ok4uw	4769	2	e	e	NNP
cord-001835-0s7ok4uw	4769	3	Mart	Mart	NNP
cord-001835-0s7ok4uw	4769	4	ınez-	ınez-	XX
cord-001835-0s7ok4uw	4770	1	Oyanedl	oyanedl	NN
cord-001835-0s7ok4uw	4770	2	1	1	CD
cord-001835-0s7ok4uw	4770	3	Fac	Fac	NNP
cord-001835-0s7ok4uw	4770	4	de	de	FW
cord-001835-0s7ok4uw	4770	5	Cs	Cs	NNP
cord-001835-0s7ok4uw	4770	6	Biol	Biol	NNP
cord-001835-0s7ok4uw	4770	7	.	.	.
cord-001835-0s7ok4uw	4771	1	,	,	,
cord-001835-0s7ok4uw	4771	2	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	4771	3	de	de	NNP
cord-001835-0s7ok4uw	4771	4	Concepci	Concepci	NNP
cord-001835-0s7ok4uw	4771	5	on	on	IN
cord-001835-0s7ok4uw	4771	6	The	the	DT
cord-001835-0s7ok4uw	4771	7	two	two	CD
cord-001835-0s7ok4uw	4771	8	chromophorylated	chromophorylate	VBN
cord-001835-0s7ok4uw	4771	9	linkers	linker	NNS
cord-001835-0s7ok4uw	4771	10	of	of	IN
cord-001835-0s7ok4uw	4771	11	R	r	NN
cord-001835-0s7ok4uw	4771	12	-	-	HYPH
cord-001835-0s7ok4uw	4771	13	Phycoerythrin	Phycoerythrin	NNP
cord-001835-0s7ok4uw	4771	14	in	in	IN
cord-001835-0s7ok4uw	4771	15	Gracilaria	Gracilaria	NNP
cord-001835-0s7ok4uw	4771	16	chilensis	chilensis	NN
cord-001835-0s7ok4uw	4771	17	.	.	.
cord-001835-0s7ok4uw	4772	1	Francisco	Francisco	NNP
cord-001835-0s7ok4uw	4772	2	Lobos	Lobos	NNP
cord-001835-0s7ok4uw	4772	3	-	-	HYPH
cord-001835-0s7ok4uw	4772	4	Gonz	Gonz	NNP
cord-001835-0s7ok4uw	4772	5	alez	alez	NN
cord-001835-0s7ok4uw	4772	6	,	,	,
cord-001835-0s7ok4uw	4772	7	Jos	Jos	NNP
cord-001835-0s7ok4uw	4772	8	e	e	NNP
cord-001835-0s7ok4uw	4772	9	Aleikar	Aleikar	NNP
cord-001835-0s7ok4uw	4772	10	V	V	NNP
cord-001835-0s7ok4uw	4772	11	asquez	asquez	NNP
cord-001835-0s7ok4uw	4772	12	,	,	,
cord-001835-0s7ok4uw	4772	13	Carola	Carola	NNP
cord-001835-0s7ok4uw	4772	14	Bruna	Bruna	NNP
cord-001835-0s7ok4uw	4772	15	,	,	,
cord-001835-0s7ok4uw	4772	16	Jos	Jos	NNP
cord-001835-0s7ok4uw	4772	17	e	e	NNP
cord-001835-0s7ok4uw	4772	18	Mart	Mart	NNP
cord-001835-0s7ok4uw	4772	19	ınez	ınez	NN
cord-001835-0s7ok4uw	4772	20	-	-	HYPH
cord-001835-0s7ok4uw	4772	21	Oyanedel	Oyanedel	NNP
cord-001835-0s7ok4uw	4772	22	,	,	,
cord-001835-0s7ok4uw	4772	23	Marta	Marta	NNP
cord-001835-0s7ok4uw	4772	24	Bunster	Bunster	NNP
cord-001835-0s7ok4uw	4772	25	.	.	.
cord-001835-0s7ok4uw	4773	1	Departamento	Departamento	NNP
cord-001835-0s7ok4uw	4773	2	de	de	NNP
cord-001835-0s7ok4uw	4773	3	Bioqu	Bioqu	NNP
cord-001835-0s7ok4uw	4773	4	ımica	ımica	NNP
cord-001835-0s7ok4uw	4774	1	y	y	NNP
cord-001835-0s7ok4uw	4774	2	Biolog	Biolog	NNP
cord-001835-0s7ok4uw	4775	1	ıa	ıa	:
cord-001835-0s7ok4uw	4775	2	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	4775	3	,	,	,
cord-001835-0s7ok4uw	4775	4	Facultad	Facultad	NNP
cord-001835-0s7ok4uw	4775	5	de	de	NNP
cord-001835-0s7ok4uw	4775	6	Ciencias	Ciencias	NNP
cord-001835-0s7ok4uw	4775	7	Biol	Biol	NNP
cord-001835-0s7ok4uw	4775	8	ogicas	ogicas	NN
cord-001835-0s7ok4uw	4775	9	,	,	,
cord-001835-0s7ok4uw	4775	10	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	4775	11	de	de	NNP
cord-001835-0s7ok4uw	4775	12	Concepci	Concepci	NNP
cord-001835-0s7ok4uw	4775	13	on	on	RP
cord-001835-0s7ok4uw	4775	14	.	.	.
cord-001835-0s7ok4uw	4776	1	Phycoerythrin	Phycoerythrin	NNP
cord-001835-0s7ok4uw	4776	2	is	be	VBZ
cord-001835-0s7ok4uw	4776	3	a	a	DT
cord-001835-0s7ok4uw	4776	4	phycobiliprotein	phycobiliprotein	NN
cord-001835-0s7ok4uw	4776	5	present	present	JJ
cord-001835-0s7ok4uw	4776	6	in	in	IN
cord-001835-0s7ok4uw	4776	7	phycobilisomes	phycobilisomes	NNP
cord-001835-0s7ok4uw	4776	8	in	in	IN
cord-001835-0s7ok4uw	4776	9	Gracilaria	Gracilaria	NNP
cord-001835-0s7ok4uw	4776	10	chilensis	chilensis	NN
cord-001835-0s7ok4uw	4776	11	as	as	IN
cord-001835-0s7ok4uw	4776	12	a	a	DT
cord-001835-0s7ok4uw	4776	13	complex	complex	NN
cord-001835-0s7ok4uw	4776	14	with	with	IN
cord-001835-0s7ok4uw	4776	15	chromophorylated	chromophorylated	JJ
cord-001835-0s7ok4uw	4776	16	linker	linker	NN
cord-001835-0s7ok4uw	4776	17	proteins	protein	NNS
cord-001835-0s7ok4uw	4776	18	.	.	.
cord-001835-0s7ok4uw	4777	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4777	2	interest	interest	NN
cord-001835-0s7ok4uw	4777	3	is	be	VBZ
cord-001835-0s7ok4uw	4777	4	to	to	TO
cord-001835-0s7ok4uw	4777	5	discover	discover	VB
cord-001835-0s7ok4uw	4777	6	the	the	DT
cord-001835-0s7ok4uw	4777	7	role	role	NN
cord-001835-0s7ok4uw	4777	8	of	of	IN
cord-001835-0s7ok4uw	4777	9	these	these	DT
cord-001835-0s7ok4uw	4777	10	linkers	linker	NNS
cord-001835-0s7ok4uw	4777	11	in	in	IN
cord-001835-0s7ok4uw	4777	12	the	the	DT
cord-001835-0s7ok4uw	4777	13	function	function	NN
cord-001835-0s7ok4uw	4777	14	of	of	IN
cord-001835-0s7ok4uw	4777	15	phycobilisomes	phycobilisomes	NNP
cord-001835-0s7ok4uw	4777	16	.	.	.
cord-001835-0s7ok4uw	4778	1	Phycobilisomes(PBP	Phycobilisomes(PBP	NNP
cord-001835-0s7ok4uw	4778	2	)	)	-RRB-
cord-001835-0s7ok4uw	4778	3	are	be	VBP
cord-001835-0s7ok4uw	4778	4	auxiliary	auxiliary	JJ
cord-001835-0s7ok4uw	4778	5	light	light	JJ
cord-001835-0s7ok4uw	4778	6	harvesting	harvesting	NN
cord-001835-0s7ok4uw	4778	7	protein	protein	NN
cord-001835-0s7ok4uw	4778	8	complexes	complex	NNS
cord-001835-0s7ok4uw	4778	9	in	in	IN
cord-001835-0s7ok4uw	4778	10	charge	charge	NN
cord-001835-0s7ok4uw	4778	11	of	of	IN
cord-001835-0s7ok4uw	4778	12	channeling	channel	VBG
cord-001835-0s7ok4uw	4778	13	energy	energy	NN
cord-001835-0s7ok4uw	4778	14	towards	towards	IN
cord-001835-0s7ok4uw	4778	15	photosystem	photosystem	NNP
cord-001835-0s7ok4uw	4778	16	II	II	NNP
cord-001835-0s7ok4uw	4778	17	in	in	IN
cord-001835-0s7ok4uw	4778	18	alga	alga	NN
cord-001835-0s7ok4uw	4778	19	,	,	,
cord-001835-0s7ok4uw	4778	20	cyanobacteria	cyanobacteria	NNS
cord-001835-0s7ok4uw	4778	21	and	and	CC
cord-001835-0s7ok4uw	4778	22	cryptophyta	cryptophyta	NN
cord-001835-0s7ok4uw	4778	23	.	.	.
cord-001835-0s7ok4uw	4779	1	This	this	DT
cord-001835-0s7ok4uw	4779	2	is	be	VBZ
cord-001835-0s7ok4uw	4779	3	possible	possible	JJ
cord-001835-0s7ok4uw	4779	4	thanks	thank	NNS
cord-001835-0s7ok4uw	4779	5	to	to	IN
cord-001835-0s7ok4uw	4779	6	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	4779	7	proteins	protein	NNS
cord-001835-0s7ok4uw	4779	8	called	call	VBN
cord-001835-0s7ok4uw	4779	9	phycobiliproteins	phycobiliproteins	NNP
cord-001835-0s7ok4uw	4779	10	(	(	-LRB-
cord-001835-0s7ok4uw	4779	11	PBP	PBP	NNP
cord-001835-0s7ok4uw	4779	12	)	)	-RRB-
cord-001835-0s7ok4uw	4779	13	and	and	CC
cord-001835-0s7ok4uw	4779	14	the	the	DT
cord-001835-0s7ok4uw	4779	15	chromophores	chromophore	NNS
cord-001835-0s7ok4uw	4779	16	(	(	-LRB-
cord-001835-0s7ok4uw	4779	17	phycobilins	phycobilin	NNS
cord-001835-0s7ok4uw	4779	18	,	,	,
cord-001835-0s7ok4uw	4779	19	open	open	JJ
cord-001835-0s7ok4uw	4779	20	-	-	HYPH
cord-001835-0s7ok4uw	4779	21	chain	chain	NN
cord-001835-0s7ok4uw	4779	22	tetrapyrrols	tetrapyrrol	NNS
cord-001835-0s7ok4uw	4779	23	)	)	-RRB-
cord-001835-0s7ok4uw	4779	24	attached	attach	VBN
cord-001835-0s7ok4uw	4779	25	to	to	IN
cord-001835-0s7ok4uw	4779	26	specific	specific	JJ
cord-001835-0s7ok4uw	4779	27	cysteines	cysteine	NNS
cord-001835-0s7ok4uw	4779	28	.	.	.
cord-001835-0s7ok4uw	4780	1	Phycobiliproteins	phycobiliprotein	NNS
cord-001835-0s7ok4uw	4780	2	share	share	VBP
cord-001835-0s7ok4uw	4780	3	a	a	DT
cord-001835-0s7ok4uw	4780	4	common	common	JJ
cord-001835-0s7ok4uw	4780	5	general	general	JJ
cord-001835-0s7ok4uw	4780	6	structure	structure	NN
cord-001835-0s7ok4uw	4780	7	;	;	:
cord-001835-0s7ok4uw	4780	8	they	-PRON-	PRP
cord-001835-0s7ok4uw	4780	9	are	be	VBP
cord-001835-0s7ok4uw	4780	10	organized	organize	VBN
cord-001835-0s7ok4uw	4780	11	as	as	IN
cord-001835-0s7ok4uw	4780	12	(	(	-LRB-
cord-001835-0s7ok4uw	4780	13	alfab	alfab	NNP
cord-001835-0s7ok4uw	4780	14	)	)	-RRB-
cord-001835-0s7ok4uw	4780	15	heterodimers	heterodimer	NNS
cord-001835-0s7ok4uw	4780	16	which	which	WDT
cord-001835-0s7ok4uw	4780	17	themselves	-PRON-	PRP
cord-001835-0s7ok4uw	4780	18	assemble	assemble	VBP
cord-001835-0s7ok4uw	4780	19	as	as	IN
cord-001835-0s7ok4uw	4780	20	trimers(alfab)3	trimers(alfab)3	NNP
cord-001835-0s7ok4uw	4780	21	or	or	CC
cord-001835-0s7ok4uw	4780	22	hexamers	hexamer	NNS
cord-001835-0s7ok4uw	4781	1	(	(	-LRB-
cord-001835-0s7ok4uw	4781	2	alfab)6	alfab)6	RB
cord-001835-0s7ok4uw	4782	1	;	;	:
cord-001835-0s7ok4uw	4782	2	this	this	DT
cord-001835-0s7ok4uw	4782	3	complexes	complex	NNS
cord-001835-0s7ok4uw	4782	4	are	be	VBP
cord-001835-0s7ok4uw	4782	5	organized	organize	VBN
cord-001835-0s7ok4uw	4782	6	in	in	IN
cord-001835-0s7ok4uw	4782	7	high	high	JJ
cord-001835-0s7ok4uw	4782	8	order	order	NN
cord-001835-0s7ok4uw	4782	9	structures	structure	NNS
cord-001835-0s7ok4uw	4782	10	to	to	TO
cord-001835-0s7ok4uw	4782	11	form	form	VB
cord-001835-0s7ok4uw	4782	12	the	the	DT
cord-001835-0s7ok4uw	4782	13	core	core	NN
cord-001835-0s7ok4uw	4782	14	and	and	CC
cord-001835-0s7ok4uw	4782	15	the	the	DT
cord-001835-0s7ok4uw	4782	16	rods	rod	NNS
cord-001835-0s7ok4uw	4782	17	.	.	.
cord-001835-0s7ok4uw	4783	1	Besides	besides	IN
cord-001835-0s7ok4uw	4783	2	PBPs	pbp	NNS
cord-001835-0s7ok4uw	4783	3	,	,	,
cord-001835-0s7ok4uw	4783	4	PBS	PBS	NNP
cord-001835-0s7ok4uw	4783	5	have	have	VBP
cord-001835-0s7ok4uw	4783	6	linker	linker	NN
cord-001835-0s7ok4uw	4783	7	proteins	protein	NNS
cord-001835-0s7ok4uw	4783	8	in	in	IN
cord-001835-0s7ok4uw	4783	9	charge	charge	NN
cord-001835-0s7ok4uw	4783	10	of	of	IN
cord-001835-0s7ok4uw	4783	11	the	the	DT
cord-001835-0s7ok4uw	4783	12	assembly	assembly	NN
cord-001835-0s7ok4uw	4783	13	and	and	CC
cord-001835-0s7ok4uw	4783	14	stabilization	stabilization	NN
cord-001835-0s7ok4uw	4783	15	of	of	IN
cord-001835-0s7ok4uw	4783	16	the	the	DT
cord-001835-0s7ok4uw	4783	17	complex	complex	NN
cord-001835-0s7ok4uw	4783	18	,	,	,
cord-001835-0s7ok4uw	4783	19	and	and	CC
cord-001835-0s7ok4uw	4783	20	also	also	RB
cord-001835-0s7ok4uw	4783	21	it	-PRON-	PRP
cord-001835-0s7ok4uw	4783	22	has	have	VBZ
cord-001835-0s7ok4uw	4783	23	been	be	VBN
cord-001835-0s7ok4uw	4783	24	proposed	propose	VBN
cord-001835-0s7ok4uw	4783	25	that	that	IN
cord-001835-0s7ok4uw	4783	26	they	-PRON-	PRP
cord-001835-0s7ok4uw	4783	27	collaborate	collaborate	VBP
cord-001835-0s7ok4uw	4783	28	in	in	IN
cord-001835-0s7ok4uw	4783	29	the	the	DT
cord-001835-0s7ok4uw	4783	30	fine	fine	JJ
cord-001835-0s7ok4uw	4783	31	tuning	tuning	NN
cord-001835-0s7ok4uw	4783	32	of	of	IN
cord-001835-0s7ok4uw	4783	33	the	the	DT
cord-001835-0s7ok4uw	4783	34	energy	energy	NN
cord-001835-0s7ok4uw	4783	35	transfer	transfer	NN
cord-001835-0s7ok4uw	4783	36	steps	step	NNS
cord-001835-0s7ok4uw	4783	37	between	between	IN
cord-001835-0s7ok4uw	4783	38	chromophores	chromophore	NNS
cord-001835-0s7ok4uw	4783	39	.	.	.
cord-001835-0s7ok4uw	4784	1	These	these	DT
cord-001835-0s7ok4uw	4784	2	linkers	linker	NNS
cord-001835-0s7ok4uw	4784	3	are	be	VBP
cord-001835-0s7ok4uw	4784	4	located	locate	VBN
cord-001835-0s7ok4uw	4784	5	within	within	IN
cord-001835-0s7ok4uw	4784	6	the	the	DT
cord-001835-0s7ok4uw	4784	7	rods	rod	NNS
cord-001835-0s7ok4uw	4784	8	,	,	,
cord-001835-0s7ok4uw	4784	9	the	the	DT
cord-001835-0s7ok4uw	4784	10	rod	rod	NN
cord-001835-0s7ok4uw	4784	11	-	-	HYPH
cord-001835-0s7ok4uw	4784	12	core	core	NN
cord-001835-0s7ok4uw	4784	13	interface	interface	NN
cord-001835-0s7ok4uw	4784	14	,	,	,
cord-001835-0s7ok4uw	4784	15	the	the	DT
cord-001835-0s7ok4uw	4784	16	core	core	NN
cord-001835-0s7ok4uw	4784	17	and	and	CC
cord-001835-0s7ok4uw	4784	18	the	the	DT
cord-001835-0s7ok4uw	4784	19	core	core	NN
cord-001835-0s7ok4uw	4784	20	-	-	HYPH
cord-001835-0s7ok4uw	4784	21	membrane	membrane	NN
cord-001835-0s7ok4uw	4784	22	interface	interface	NN
cord-001835-0s7ok4uw	4784	23	.	.	.
cord-001835-0s7ok4uw	4785	1	Although	although	IN
cord-001835-0s7ok4uw	4785	2	most	most	JJS
cord-001835-0s7ok4uw	4785	3	linker	linker	NN
cord-001835-0s7ok4uw	4785	4	proteins	protein	NNS
cord-001835-0s7ok4uw	4785	5	are	be	VBP
cord-001835-0s7ok4uw	4785	6	colorless	colorless	JJ
cord-001835-0s7ok4uw	4785	7	,	,	,
cord-001835-0s7ok4uw	4785	8	chromophore	chromophore	NN
cord-001835-0s7ok4uw	4785	9	bearing	bearing	NN
cord-001835-0s7ok4uw	4785	10	linkers	linker	NNS
cord-001835-0s7ok4uw	4785	11	have	have	VBP
cord-001835-0s7ok4uw	4785	12	been	be	VBN
cord-001835-0s7ok4uw	4785	13	described	describe	VBN
cord-001835-0s7ok4uw	4785	14	,	,	,
cord-001835-0s7ok4uw	4785	15	which	which	WDT
cord-001835-0s7ok4uw	4785	16	suggest	suggest	VBP
cord-001835-0s7ok4uw	4785	17	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4785	18	participation	participation	NN
cord-001835-0s7ok4uw	4785	19	in	in	IN
cord-001835-0s7ok4uw	4785	20	the	the	DT
cord-001835-0s7ok4uw	4785	21	energy	energy	NN
cord-001835-0s7ok4uw	4785	22	transfer	transfer	NN
cord-001835-0s7ok4uw	4785	23	process	process	NN
cord-001835-0s7ok4uw	4785	24	.	.	.
cord-001835-0s7ok4uw	4786	1	Two	two	CD
cord-001835-0s7ok4uw	4786	2	of	of	IN
cord-001835-0s7ok4uw	4786	3	them	-PRON-	PRP
cord-001835-0s7ok4uw	4786	4	,	,	,
cord-001835-0s7ok4uw	4786	5	g	g	NNP
cord-001835-0s7ok4uw	4786	6	31	31	CD
cord-001835-0s7ok4uw	4786	7	and	and	CC
cord-001835-0s7ok4uw	4786	8	g	g	NNP
cord-001835-0s7ok4uw	4786	9	33	33	CD
cord-001835-0s7ok4uw	4786	10	are	be	VBP
cord-001835-0s7ok4uw	4786	11	associated	associate	VBN
cord-001835-0s7ok4uw	4786	12	to	to	IN
cord-001835-0s7ok4uw	4786	13	R	r	NN
cord-001835-0s7ok4uw	4786	14	-	-	NN
cord-001835-0s7ok4uw	4786	15	phycoerythrin	phycoerythrin	NN
cord-001835-0s7ok4uw	4786	16	in	in	IN
cord-001835-0s7ok4uw	4786	17	Gracilaria	Gracilaria	NNP
cord-001835-0s7ok4uw	4786	18	chilensis	chilensis	NN
cord-001835-0s7ok4uw	4786	19	,	,	,
cord-001835-0s7ok4uw	4786	20	nevertheless	nevertheless	RB
cord-001835-0s7ok4uw	4786	21	the	the	DT
cord-001835-0s7ok4uw	4786	22	information	information	NN
cord-001835-0s7ok4uw	4786	23	available	available	JJ
cord-001835-0s7ok4uw	4786	24	on	on	IN
cord-001835-0s7ok4uw	4786	25	these	these	DT
cord-001835-0s7ok4uw	4786	26	linkers	linker	NNS
cord-001835-0s7ok4uw	4786	27	in	in	IN
cord-001835-0s7ok4uw	4786	28	eukaryots	eukaryot	NNS
cord-001835-0s7ok4uw	4786	29	is	be	VBZ
cord-001835-0s7ok4uw	4786	30	still	still	RB
cord-001835-0s7ok4uw	4786	31	limited	limited	JJ
cord-001835-0s7ok4uw	4786	32	.	.	.
cord-001835-0s7ok4uw	4787	1	To	to	TO
cord-001835-0s7ok4uw	4787	2	understand	understand	VB
cord-001835-0s7ok4uw	4787	3	how	how	WRB
cord-001835-0s7ok4uw	4787	4	these	these	DT
cord-001835-0s7ok4uw	4787	5	linkers	linker	NNS
cord-001835-0s7ok4uw	4787	6	collaborate	collaborate	VBP
cord-001835-0s7ok4uw	4787	7	with	with	IN
cord-001835-0s7ok4uw	4787	8	the	the	DT
cord-001835-0s7ok4uw	4787	9	function	function	NN
cord-001835-0s7ok4uw	4787	10	of	of	IN
cord-001835-0s7ok4uw	4787	11	the	the	DT
cord-001835-0s7ok4uw	4787	12	phycobilisome	phycobilisome	NN
cord-001835-0s7ok4uw	4787	13	,	,	,
cord-001835-0s7ok4uw	4787	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	4787	15	need	need	VBP
cord-001835-0s7ok4uw	4787	16	structural	structural	JJ
cord-001835-0s7ok4uw	4787	17	information	information	NN
cord-001835-0s7ok4uw	4787	18	,	,	,
cord-001835-0s7ok4uw	4787	19	especially	especially	RB
cord-001835-0s7ok4uw	4787	20	the	the	DT
cord-001835-0s7ok4uw	4787	21	coordinates	coordinate	NNS
cord-001835-0s7ok4uw	4787	22	of	of	IN
cord-001835-0s7ok4uw	4787	23	all	all	PDT
cord-001835-0s7ok4uw	4787	24	the	the	DT
cord-001835-0s7ok4uw	4787	25	chromophores	chromophore	NNS
cord-001835-0s7ok4uw	4787	26	present	present	JJ
cord-001835-0s7ok4uw	4787	27	in	in	IN
cord-001835-0s7ok4uw	4787	28	the	the	DT
cord-001835-0s7ok4uw	4787	29	complex	complex	NN
cord-001835-0s7ok4uw	4787	30	;	;	:
cord-001835-0s7ok4uw	4787	31	we	-PRON-	PRP
cord-001835-0s7ok4uw	4787	32	have	have	VBP
cord-001835-0s7ok4uw	4787	33	sequenced	sequence	VBN
cord-001835-0s7ok4uw	4787	34	both	both	DT
cord-001835-0s7ok4uw	4787	35	linkers	linker	NNS
cord-001835-0s7ok4uw	4787	36	from	from	IN
cord-001835-0s7ok4uw	4787	37	the	the	DT
cord-001835-0s7ok4uw	4787	38	genomic	genomic	JJ
cord-001835-0s7ok4uw	4787	39	dna	dna	NN
cord-001835-0s7ok4uw	4787	40	,	,	,
cord-001835-0s7ok4uw	4787	41	performed	perform	VBD
cord-001835-0s7ok4uw	4787	42	sequence	sequence	NN
cord-001835-0s7ok4uw	4787	43	analysis	analysis	NN
cord-001835-0s7ok4uw	4787	44	and	and	CC
cord-001835-0s7ok4uw	4787	45	also	also	RB
cord-001835-0s7ok4uw	4787	46	we	-PRON-	PRP
cord-001835-0s7ok4uw	4787	47	have	have	VBP
cord-001835-0s7ok4uw	4787	48	purified	purify	VBN
cord-001835-0s7ok4uw	4787	49	the	the	DT
cord-001835-0s7ok4uw	4787	50	linkers	linker	NNS
cord-001835-0s7ok4uw	4787	51	by	by	IN
cord-001835-0s7ok4uw	4787	52	anion	anion	NN
cord-001835-0s7ok4uw	4787	53	exchange	exchange	NN
cord-001835-0s7ok4uw	4787	54	,	,	,
cord-001835-0s7ok4uw	4787	55	molecular	molecular	JJ
cord-001835-0s7ok4uw	4787	56	sieve	sieve	NN
cord-001835-0s7ok4uw	4787	57	and	and	CC
cord-001835-0s7ok4uw	4787	58	HPL	HPL	NNP
cord-001835-0s7ok4uw	4787	59	Chromatography	Chromatography	NNP
cord-001835-0s7ok4uw	4787	60	.	.	.
cord-001835-0s7ok4uw	4788	1	The	the	DT
cord-001835-0s7ok4uw	4788	2	characterization	characterization	NN
cord-001835-0s7ok4uw	4788	3	was	be	VBD
cord-001835-0s7ok4uw	4788	4	performed	perform	VBN
cord-001835-0s7ok4uw	4788	5	by	by	IN
cord-001835-0s7ok4uw	4788	6	denaturant	denaturant	JJ
cord-001835-0s7ok4uw	4788	7	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	4788	8	,	,	,
cord-001835-0s7ok4uw	4788	9	absorption	absorption	NN
cord-001835-0s7ok4uw	4788	10	and	and	CC
cord-001835-0s7ok4uw	4788	11	emission	emission	NN
cord-001835-0s7ok4uw	4788	12	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	4788	13	and	and	CC
cord-001835-0s7ok4uw	4788	14	by	by	IN
cord-001835-0s7ok4uw	4788	15	mass	mass	NN
cord-001835-0s7ok4uw	4788	16	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4788	17	.	.	.
cord-001835-0s7ok4uw	4789	1	The	the	DT
cord-001835-0s7ok4uw	4789	2	results	result	NNS
cord-001835-0s7ok4uw	4789	3	show	show	VBP
cord-001835-0s7ok4uw	4789	4	that	that	IN
cord-001835-0s7ok4uw	4789	5	they	-PRON-	PRP
cord-001835-0s7ok4uw	4789	6	have	have	VBP
cord-001835-0s7ok4uw	4789	7	molecular	molecular	JJ
cord-001835-0s7ok4uw	4789	8	masses	masse	NNS
cord-001835-0s7ok4uw	4789	9	as	as	IN
cord-001835-0s7ok4uw	4789	10	predicted	predict	VBN
cord-001835-0s7ok4uw	4789	11	,	,	,
cord-001835-0s7ok4uw	4789	12	with	with	IN
cord-001835-0s7ok4uw	4789	13	a	a	DT
cord-001835-0s7ok4uw	4789	14	peptide	peptide	JJ
cord-001835-0s7ok4uw	4789	15	signal	signal	NN
cord-001835-0s7ok4uw	4789	16	for	for	IN
cord-001835-0s7ok4uw	4789	17	chloroplasts	chloroplast	NNS
cord-001835-0s7ok4uw	4789	18	,	,	,
cord-001835-0s7ok4uw	4789	19	an	an	DT
cord-001835-0s7ok4uw	4789	20	internal	internal	JJ
cord-001835-0s7ok4uw	4789	21	sequence	sequence	NN
cord-001835-0s7ok4uw	4789	22	repeat	repeat	NN
cord-001835-0s7ok4uw	4789	23	;	;	:
cord-001835-0s7ok4uw	4789	24	residues	residue	NNS
cord-001835-0s7ok4uw	4789	25	67	67	CD
cord-001835-0s7ok4uw	4789	26	-170	-170	NN
cord-001835-0s7ok4uw	4789	27	with	with	IN
cord-001835-0s7ok4uw	4789	28	residues	residue	NNS
cord-001835-0s7ok4uw	4789	29	179	179	CD
cord-001835-0s7ok4uw	4789	30	-273	-273	NN
cord-001835-0s7ok4uw	4789	31	for	for	IN
cord-001835-0s7ok4uw	4789	32	g	g	NNP
cord-001835-0s7ok4uw	4789	33	31	31	CD
cord-001835-0s7ok4uw	4789	34	and	and	CC
cord-001835-0s7ok4uw	4789	35	residues	residue	NNS
cord-001835-0s7ok4uw	4789	36	107	107	CD
cord-001835-0s7ok4uw	4789	37	-	-	HYPH
cord-001835-0s7ok4uw	4789	38	200	200	CD
cord-001835-0s7ok4uw	4789	39	with	with	IN
cord-001835-0s7ok4uw	4789	40	residues	residue	NNS
cord-001835-0s7ok4uw	4789	41	219	219	CD
cord-001835-0s7ok4uw	4789	42	-	-	SYM
cord-001835-0s7ok4uw	4789	43	315	315	CD
cord-001835-0s7ok4uw	4789	44	for	for	IN
cord-001835-0s7ok4uw	4789	45	g	g	NNP
cord-001835-0s7ok4uw	4789	46	33	33	CD
cord-001835-0s7ok4uw	4789	47	,	,	,
cord-001835-0s7ok4uw	4789	48	and	and	CC
cord-001835-0s7ok4uw	4789	49	the	the	DT
cord-001835-0s7ok4uw	4789	50	presence	presence	NN
cord-001835-0s7ok4uw	4789	51	of	of	IN
cord-001835-0s7ok4uw	4789	52	conserved	conserve	VBN
cord-001835-0s7ok4uw	4789	53	cysteine	cysteine	NN
cord-001835-0s7ok4uw	4789	54	residues	residue	NNS
cord-001835-0s7ok4uw	4789	55	putative	putative	JJ
cord-001835-0s7ok4uw	4789	56	sites	site	NNS
cord-001835-0s7ok4uw	4789	57	of	of	IN
cord-001835-0s7ok4uw	4789	58	chromophorylation	chromophorylation	NNP
cord-001835-0s7ok4uw	4789	59	.	.	.
cord-001835-0s7ok4uw	4790	1	The	the	DT
cord-001835-0s7ok4uw	4790	2	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	4790	3	shows	show	VBZ
cord-001835-0s7ok4uw	4790	4	that	that	IN
cord-001835-0s7ok4uw	4790	5	they	-PRON-	PRP
cord-001835-0s7ok4uw	4790	6	have	have	VBP
cord-001835-0s7ok4uw	4790	7	different	different	JJ
cord-001835-0s7ok4uw	4790	8	composition	composition	NN
cord-001835-0s7ok4uw	4790	9	of	of	IN
cord-001835-0s7ok4uw	4790	10	phycobilins	phycobilin	NNS
cord-001835-0s7ok4uw	4790	11	and	and	CC
cord-001835-0s7ok4uw	4790	12	a	a	DT
cord-001835-0s7ok4uw	4790	13	very	very	RB
cord-001835-0s7ok4uw	4790	14	short	short	JJ
cord-001835-0s7ok4uw	4790	15	t1/2	t1/2	NN
cord-001835-0s7ok4uw	4790	16	.	.	.
cord-001835-0s7ok4uw	4791	1	A	a	DT
cord-001835-0s7ok4uw	4791	2	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	4791	3	model	model	NN
cord-001835-0s7ok4uw	4791	4	for	for	IN
cord-001835-0s7ok4uw	4791	5	both	both	DT
cord-001835-0s7ok4uw	4791	6	linkers	linker	NNS
cord-001835-0s7ok4uw	4791	7	shows	show	VBZ
cord-001835-0s7ok4uw	4791	8	that	that	IN
cord-001835-0s7ok4uw	4791	9	they	-PRON-	PRP
cord-001835-0s7ok4uw	4791	10	belong	belong	VBP
cord-001835-0s7ok4uw	4791	11	to	to	IN
cord-001835-0s7ok4uw	4791	12	aa	aa	NNP
cord-001835-0s7ok4uw	4791	13	structural	structural	JJ
cord-001835-0s7ok4uw	4791	14	class	class	NN
cord-001835-0s7ok4uw	4791	15	and	and	CC
cord-001835-0s7ok4uw	4791	16	that	that	IN
cord-001835-0s7ok4uw	4791	17	they	-PRON-	PRP
cord-001835-0s7ok4uw	4791	18	share	share	VBP
cord-001835-0s7ok4uw	4791	19	a	a	DT
cord-001835-0s7ok4uw	4791	20	common	common	JJ
cord-001835-0s7ok4uw	4791	21	fold	fold	NN
cord-001835-0s7ok4uw	4791	22	(	(	-LRB-
cord-001835-0s7ok4uw	4791	23	HEAT	heat	NN
cord-001835-0s7ok4uw	4791	24	like	like	IN
cord-001835-0s7ok4uw	4791	25	motifs	motif	NNS
cord-001835-0s7ok4uw	4791	26	)	)	-RRB-
cord-001835-0s7ok4uw	4791	27	frequently	frequently	RB
cord-001835-0s7ok4uw	4791	28	involved	involve	VBN
cord-001835-0s7ok4uw	4791	29	in	in	IN
cord-001835-0s7ok4uw	4791	30	protein	protein	NN
cord-001835-0s7ok4uw	4791	31	-	-	HYPH
cord-001835-0s7ok4uw	4791	32	protein	protein	NN
cord-001835-0s7ok4uw	4791	33	interactions	interaction	NNS
cord-001835-0s7ok4uw	4791	34	.	.	.
cord-001835-0s7ok4uw	4792	1	Dept	Dept	NNP
cord-001835-0s7ok4uw	4792	2	.	.	NNP
cord-001835-0s7ok4uw	4792	3	of	of	IN
cord-001835-0s7ok4uw	4792	4	Phys	Phys	NNP
cord-001835-0s7ok4uw	4792	5	.	.	NNP
cord-001835-0s7ok4uw	4792	6	,	,	,
cord-001835-0s7ok4uw	4792	7	Chuo	Chuo	NNP
cord-001835-0s7ok4uw	4792	8	Univ	Univ	NNP
cord-001835-0s7ok4uw	4792	9	.	.	.
cord-001835-0s7ok4uw	4793	1	,	,	,
cord-001835-0s7ok4uw	4793	2	2	2	CD
cord-001835-0s7ok4uw	4793	3	Grad	grad	NN
cord-001835-0s7ok4uw	4793	4	.	.	.
cord-001835-0s7ok4uw	4794	1	Sch	Sch	NNP
cord-001835-0s7ok4uw	4794	2	.	.	.
cord-001835-0s7ok4uw	4795	1	of	of	IN
cord-001835-0s7ok4uw	4795	2	Inform	Inform	NNP
cord-001835-0s7ok4uw	4795	3	.	.	.
cord-001835-0s7ok4uw	4796	1	Sci	Sci	NNP
cord-001835-0s7ok4uw	4796	2	.	.	NNP
cord-001835-0s7ok4uw	4796	3	and	and	CC
cord-001835-0s7ok4uw	4796	4	Eng	Eng	NNP
cord-001835-0s7ok4uw	4796	5	.	.	.
cord-001835-0s7ok4uw	4797	1	,	,	,
cord-001835-0s7ok4uw	4797	2	Tokyo	Tokyo	NNP
cord-001835-0s7ok4uw	4797	3	Tech	Tech	NNP
cord-001835-0s7ok4uw	4797	4	,	,	,
cord-001835-0s7ok4uw	4797	5	3	3	CD
cord-001835-0s7ok4uw	4797	6	 	 	_SP
cord-001835-0s7ok4uw	4797	7	Rigid	rigid	JJ
cord-001835-0s7ok4uw	4797	8	-	-	HYPH
cord-001835-0s7ok4uw	4797	9	body	body	NN
cord-001835-0s7ok4uw	4797	10	docking	docking	NN
cord-001835-0s7ok4uw	4797	11	algorithms	algorithm	NNS
cord-001835-0s7ok4uw	4797	12	are	be	VBP
cord-001835-0s7ok4uw	4797	13	useful	useful	JJ
cord-001835-0s7ok4uw	4797	14	for	for	IN
cord-001835-0s7ok4uw	4797	15	predicting	predict	VBG
cord-001835-0s7ok4uw	4797	16	tertiary	tertiary	JJ
cord-001835-0s7ok4uw	4797	17	structures	structure	NNS
cord-001835-0s7ok4uw	4797	18	of	of	IN
cord-001835-0s7ok4uw	4797	19	near	near	JJ
cord-001835-0s7ok4uw	4797	20	-	-	HYPH
cord-001835-0s7ok4uw	4797	21	native	native	JJ
cord-001835-0s7ok4uw	4797	22	protein	protein	NN
cord-001835-0s7ok4uw	4797	23	complexes	complex	NNS
cord-001835-0s7ok4uw	4797	24	.	.	.
cord-001835-0s7ok4uw	4798	1	However	however	RB
cord-001835-0s7ok4uw	4798	2	,	,	,
cord-001835-0s7ok4uw	4798	3	this	this	DT
cord-001835-0s7ok4uw	4798	4	algorithms	algorithm	NNS
cord-001835-0s7ok4uw	4798	5	generate	generate	VBP
cord-001835-0s7ok4uw	4798	6	many	many	JJ
cord-001835-0s7ok4uw	4798	7	protein	protein	NN
cord-001835-0s7ok4uw	4798	8	complex	complex	NN
cord-001835-0s7ok4uw	4798	9	poses	pose	VBZ
cord-001835-0s7ok4uw	4798	10	including	include	VBG
cord-001835-0s7ok4uw	4798	11	false	false	JJ
cord-001835-0s7ok4uw	4798	12	positives	positive	NNS
cord-001835-0s7ok4uw	4798	13	.	.	.
cord-001835-0s7ok4uw	4799	1	Then	then	RB
cord-001835-0s7ok4uw	4799	2	,	,	,
cord-001835-0s7ok4uw	4799	3	near	near	JJ
cord-001835-0s7ok4uw	4799	4	-	-	HYPH
cord-001835-0s7ok4uw	4799	5	native	native	JJ
cord-001835-0s7ok4uw	4799	6	poses	pose	NNS
cord-001835-0s7ok4uw	4799	7	are	be	VBP
cord-001835-0s7ok4uw	4799	8	searched	search	VBN
cord-001835-0s7ok4uw	4799	9	in	in	IN
cord-001835-0s7ok4uw	4799	10	a	a	DT
cord-001835-0s7ok4uw	4799	11	post	post	JJ
cord-001835-0s7ok4uw	4799	12	-	-	JJ
cord-001835-0s7ok4uw	4799	13	docking	docking	JJ
cord-001835-0s7ok4uw	4799	14	process	process	NN
cord-001835-0s7ok4uw	4799	15	.	.	.
cord-001835-0s7ok4uw	4800	1	There	there	EX
cord-001835-0s7ok4uw	4800	2	are	be	VBP
cord-001835-0s7ok4uw	4800	3	many	many	JJ
cord-001835-0s7ok4uw	4800	4	computational	computational	JJ
cord-001835-0s7ok4uw	4800	5	softwares	software	NNS
cord-001835-0s7ok4uw	4800	6	with	with	IN
cord-001835-0s7ok4uw	4800	7	rigid	rigid	JJ
cord-001835-0s7ok4uw	4800	8	-	-	HYPH
cord-001835-0s7ok4uw	4800	9	body	body	NN
cord-001835-0s7ok4uw	4800	10	docking	docking	NN
cord-001835-0s7ok4uw	4800	11	algorithms	algorithm	NNS
cord-001835-0s7ok4uw	4800	12	,	,	,
cord-001835-0s7ok4uw	4800	13	for	for	IN
cord-001835-0s7ok4uw	4800	14	example	example	NN
cord-001835-0s7ok4uw	4800	15	,	,	,
cord-001835-0s7ok4uw	4800	16	ZDOCK	ZDOCK	NNP
cord-001835-0s7ok4uw	4800	17	.	.	.
cord-001835-0s7ok4uw	4801	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4801	2	developed	develop	VBD
cord-001835-0s7ok4uw	4801	3	a	a	DT
cord-001835-0s7ok4uw	4801	4	high	high	JJ
cord-001835-0s7ok4uw	4801	5	-	-	HYPH
cord-001835-0s7ok4uw	4801	6	performance	performance	NN
cord-001835-0s7ok4uw	4801	7	protein	protein	NN
cord-001835-0s7ok4uw	4801	8	-	-	HYPH
cord-001835-0s7ok4uw	4801	9	protein	protein	NN
cord-001835-0s7ok4uw	4801	10	interaction	interaction	NN
cord-001835-0s7ok4uw	4801	11	prediction	prediction	NN
cord-001835-0s7ok4uw	4801	12	software	software	NN
cord-001835-0s7ok4uw	4801	13	,	,	,
cord-001835-0s7ok4uw	4801	14	MEGADOCK	MEGADOCK	NNP
cord-001835-0s7ok4uw	4801	15	,	,	,
cord-001835-0s7ok4uw	4801	16	which	which	WDT
cord-001835-0s7ok4uw	4801	17	is	be	VBZ
cord-001835-0s7ok4uw	4801	18	basically	basically	RB
cord-001835-0s7ok4uw	4801	19	used	use	VBN
cord-001835-0s7ok4uw	4801	20	on	on	IN
cord-001835-0s7ok4uw	4801	21	supercomputing	supercompute	VBG
cord-001835-0s7ok4uw	4801	22	environments	environment	NNS
cord-001835-0s7ok4uw	4801	23	for	for	IN
cord-001835-0s7ok4uw	4801	24	a	a	DT
cord-001835-0s7ok4uw	4801	25	large	large	JJ
cord-001835-0s7ok4uw	4801	26	scale	scale	NN
cord-001835-0s7ok4uw	4801	27	and	and	CC
cord-001835-0s7ok4uw	4801	28	network	network	NN
cord-001835-0s7ok4uw	4801	29	level	level	NN
cord-001835-0s7ok4uw	4801	30	In	in	IN
cord-001835-0s7ok4uw	4801	31	this	this	DT
cord-001835-0s7ok4uw	4801	32	work	work	NN
cord-001835-0s7ok4uw	4801	33	,	,	,
cord-001835-0s7ok4uw	4801	34	we	-PRON-	PRP
cord-001835-0s7ok4uw	4801	35	then	then	RB
cord-001835-0s7ok4uw	4801	36	tried	try	VBD
cord-001835-0s7ok4uw	4801	37	to	to	TO
cord-001835-0s7ok4uw	4801	38	use	use	VB
cord-001835-0s7ok4uw	4801	39	these	these	DT
cord-001835-0s7ok4uw	4801	40	docking	docking	NN
cord-001835-0s7ok4uw	4801	41	softwares	software	NNS
cord-001835-0s7ok4uw	4801	42	and	and	CC
cord-001835-0s7ok4uw	4801	43	the	the	DT
cord-001835-0s7ok4uw	4801	44	profile	profile	NN
cord-001835-0s7ok4uw	4801	45	method	method	NN
cord-001835-0s7ok4uw	4801	46	for	for	IN
cord-001835-0s7ok4uw	4801	47	understanding	understanding	NN
cord-001835-0s7ok4uw	4801	48	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4801	49	of	of	IN
cord-001835-0s7ok4uw	4801	50	protein	protein	NN
cord-001835-0s7ok4uw	4801	51	-	-	HYPH
cord-001835-0s7ok4uw	4801	52	protein	protein	NN
cord-001835-0s7ok4uw	4801	53	interactions	interaction	NNS
cord-001835-0s7ok4uw	4801	54	.	.	.
cord-001835-0s7ok4uw	4802	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4802	2	focused	focus	VBD
cord-001835-0s7ok4uw	4802	3	on	on	IN
cord-001835-0s7ok4uw	4802	4	some	some	DT
cord-001835-0s7ok4uw	4802	5	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	4802	6	properties	property	NNS
cord-001835-0s7ok4uw	4802	7	,	,	,
cord-001835-0s7ok4uw	4802	8	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	4802	9	and	and	CC
cord-001835-0s7ok4uw	4802	10	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	4802	11	,	,	,
cord-001835-0s7ok4uw	4802	12	of	of	IN
cord-001835-0s7ok4uw	4802	13	a	a	DT
cord-001835-0s7ok4uw	4802	14	set	set	NN
cord-001835-0s7ok4uw	4802	15	of	of	IN
cord-001835-0s7ok4uw	4802	16	protein	protein	NN
cord-001835-0s7ok4uw	4802	17	complex	complex	NN
cord-001835-0s7ok4uw	4802	18	poses	pose	NNS
cord-001835-0s7ok4uw	4802	19	generated	generate	VBN
cord-001835-0s7ok4uw	4802	20	by	by	IN
cord-001835-0s7ok4uw	4802	21	a	a	DT
cord-001835-0s7ok4uw	4802	22	rigid	rigid	JJ
cord-001835-0s7ok4uw	4802	23	-	-	HYPH
cord-001835-0s7ok4uw	4802	24	body	body	NN
cord-001835-0s7ok4uw	4802	25	docking	docking	NN
cord-001835-0s7ok4uw	4802	26	process	process	NN
cord-001835-0s7ok4uw	4802	27	.	.	.
cord-001835-0s7ok4uw	4803	1	From	from	IN
cord-001835-0s7ok4uw	4803	2	these	these	DT
cord-001835-0s7ok4uw	4803	3	poses	pose	NNS
cord-001835-0s7ok4uw	4803	4	,	,	,
cord-001835-0s7ok4uw	4803	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4803	6	obtained	obtain	VBD
cord-001835-0s7ok4uw	4803	7	sets	set	NNS
cord-001835-0s7ok4uw	4803	8	of	of	IN
cord-001835-0s7ok4uw	4803	9	possible	possible	JJ
cord-001835-0s7ok4uw	4803	10	interacting	interact	VBG
cord-001835-0s7ok4uw	4803	11	amino	amino	NN
cord-001835-0s7ok4uw	4803	12	acid	acid	NN
cord-001835-0s7ok4uw	4803	13	pairs	pair	NNS
cord-001835-0s7ok4uw	4803	14	.	.	.
cord-001835-0s7ok4uw	4804	1	A	a	DT
cord-001835-0s7ok4uw	4804	2	set	set	NN
cord-001835-0s7ok4uw	4804	3	of	of	IN
cord-001835-0s7ok4uw	4804	4	interaction	interaction	NN
cord-001835-0s7ok4uw	4804	5	profiles	profile	NNS
cord-001835-0s7ok4uw	4804	6	has	have	VBZ
cord-001835-0s7ok4uw	4804	7	some	some	DT
cord-001835-0s7ok4uw	4804	8	information	information	NN
cord-001835-0s7ok4uw	4804	9	of	of	IN
cord-001835-0s7ok4uw	4804	10	docking	docking	NN
cord-001835-0s7ok4uw	4804	11	spaces	space	NNS
cord-001835-0s7ok4uw	4804	12	.	.	.
cord-001835-0s7ok4uw	4805	1	From	from	IN
cord-001835-0s7ok4uw	4805	2	the	the	DT
cord-001835-0s7ok4uw	4805	3	view	view	NN
cord-001835-0s7ok4uw	4805	4	of	of	IN
cord-001835-0s7ok4uw	4805	5	a	a	DT
cord-001835-0s7ok4uw	4805	6	network	network	NN
cord-001835-0s7ok4uw	4805	7	prediction	prediction	NN
cord-001835-0s7ok4uw	4805	8	,	,	,
cord-001835-0s7ok4uw	4805	9	the	the	DT
cord-001835-0s7ok4uw	4805	10	docking	docking	NN
cord-001835-0s7ok4uw	4805	11	spaces	space	NNS
cord-001835-0s7ok4uw	4805	12	of	of	IN
cord-001835-0s7ok4uw	4805	13	a	a	DT
cord-001835-0s7ok4uw	4805	14	set	set	NN
cord-001835-0s7ok4uw	4805	15	of	of	IN
cord-001835-0s7ok4uw	4805	16	protein	protein	NN
cord-001835-0s7ok4uw	4805	17	complex	complex	NN
cord-001835-0s7ok4uw	4805	18	poses	pose	NNS
cord-001835-0s7ok4uw	4805	19	are	be	VBP
cord-001835-0s7ok4uw	4805	20	one	one	CD
cord-001835-0s7ok4uw	4805	21	of	of	IN
cord-001835-0s7ok4uw	4805	22	the	the	DT
cord-001835-0s7ok4uw	4805	23	properties	property	NNS
cord-001835-0s7ok4uw	4805	24	for	for	IN
cord-001835-0s7ok4uw	4805	25	discriminating	discriminate	VBG
cord-001835-0s7ok4uw	4805	26	native	native	JJ
cord-001835-0s7ok4uw	4805	27	protein	protein	NN
cord-001835-0s7ok4uw	4805	28	-	-	HYPH
cord-001835-0s7ok4uw	4805	29	protein	protein	NN
cord-001835-0s7ok4uw	4805	30	pairs	pair	NNS
cord-001835-0s7ok4uw	4805	31	from	from	IN
cord-001835-0s7ok4uw	4805	32	non	non	JJ
cord-001835-0s7ok4uw	4805	33	-	-	JJ
cord-001835-0s7ok4uw	4805	34	native	native	JJ
cord-001835-0s7ok4uw	4805	35	pairs	pair	NNS
cord-001835-0s7ok4uw	4805	36	.	.	.
cord-001835-0s7ok4uw	4806	1	In	in	IN
cord-001835-0s7ok4uw	4806	2	this	this	DT
cord-001835-0s7ok4uw	4806	3	work	work	NN
cord-001835-0s7ok4uw	4806	4	,	,	,
cord-001835-0s7ok4uw	4806	5	ensemble	ensemble	JJ
cord-001835-0s7ok4uw	4806	6	docking	docking	NN
cord-001835-0s7ok4uw	4806	7	process	process	NN
cord-001835-0s7ok4uw	4806	8	is	be	VBZ
cord-001835-0s7ok4uw	4806	9	performed	perform	VBN
cord-001835-0s7ok4uw	4806	10	by	by	IN
cord-001835-0s7ok4uw	4806	11	MEGADOCK	MEGADOCK	NNP
cord-001835-0s7ok4uw	4806	12	ver	ver	NNP
cord-001835-0s7ok4uw	4806	13	.	.	.
cord-001835-0s7ok4uw	4807	1	4.0	4.0	CD
cord-001835-0s7ok4uw	4807	2	and	and	CC
cord-001835-0s7ok4uw	4807	3	ZDOCK	ZDOCK	NNP
cord-001835-0s7ok4uw	4807	4	ver	ver	NN
cord-001835-0s7ok4uw	4807	5	.	.	.
cord-001835-0s7ok4uw	4808	1	3.0.1	3.0.1	UH
cord-001835-0s7ok4uw	4808	2	.	.	.
cord-001835-0s7ok4uw	4809	1	Cluster	cluster	NN
cord-001835-0s7ok4uw	4809	2	analysis	analysis	NN
cord-001835-0s7ok4uw	4809	3	is	be	VBZ
cord-001835-0s7ok4uw	4809	4	used	use	VBN
cord-001835-0s7ok4uw	4809	5	with	with	IN
cord-001835-0s7ok4uw	4809	6	profiles	profile	NNS
cord-001835-0s7ok4uw	4809	7	of	of	IN
cord-001835-0s7ok4uw	4809	8	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	4809	9	properties	property	NNS
cord-001835-0s7ok4uw	4809	10	.	.	.
cord-001835-0s7ok4uw	4810	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4810	2	used	use	VBD
cord-001835-0s7ok4uw	4810	3	a	a	DT
cord-001835-0s7ok4uw	4810	4	dataset	dataset	NN
cord-001835-0s7ok4uw	4810	5	composed	compose	VBN
cord-001835-0s7ok4uw	4810	6	of	of	IN
cord-001835-0s7ok4uw	4810	7	typical	typical	JJ
cord-001835-0s7ok4uw	4810	8	44	44	CD
cord-001835-0s7ok4uw	4810	9	monomer	monomer	NN
cord-001835-0s7ok4uw	4810	10	-	-	HYPH
cord-001835-0s7ok4uw	4810	11	monomer	monomer	NN
cord-001835-0s7ok4uw	4810	12	protein	protein	NN
cord-001835-0s7ok4uw	4810	13	pairs	pair	NNS
cord-001835-0s7ok4uw	4810	14	and	and	CC
cord-001835-0s7ok4uw	4810	15	will	will	MD
cord-001835-0s7ok4uw	4810	16	discuss	discuss	VB
cord-001835-0s7ok4uw	4810	17	mainly	mainly	RB
cord-001835-0s7ok4uw	4810	18	differences	difference	NNS
cord-001835-0s7ok4uw	4810	19	between	between	IN
cord-001835-0s7ok4uw	4810	20	native	native	JJ
cord-001835-0s7ok4uw	4810	21	and	and	CC
cord-001835-0s7ok4uw	4810	22	non	non	JJ
cord-001835-0s7ok4uw	4810	23	-	-	JJ
cord-001835-0s7ok4uw	4810	24	native	native	JJ
cord-001835-0s7ok4uw	4810	25	protein	protein	NN
cord-001835-0s7ok4uw	4810	26	pairs	pair	NNS
cord-001835-0s7ok4uw	4810	27	.	.	.
cord-001835-0s7ok4uw	4811	1	The	the	DT
cord-001835-0s7ok4uw	4811	2	structural	structural	JJ
cord-001835-0s7ok4uw	4811	3	studies	study	NNS
cord-001835-0s7ok4uw	4811	4	of	of	IN
cord-001835-0s7ok4uw	4811	5	the	the	DT
cord-001835-0s7ok4uw	4811	6	two	two	CD
cord-001835-0s7ok4uw	4811	7	thermostable	thermostable	JJ
cord-001835-0s7ok4uw	4811	8	laccases	laccase	NNS
cord-001835-0s7ok4uw	4811	9	from	from	IN
cord-001835-0s7ok4uw	4811	10	the	the	DT
cord-001835-0s7ok4uw	4811	11	white	white	JJ
cord-001835-0s7ok4uw	4811	12	-	-	HYPH
cord-001835-0s7ok4uw	4811	13	rot	rot	NN
cord-001835-0s7ok4uw	4811	14	fungi	fungus	NNS
cord-001835-0s7ok4uw	4811	15	Pycnoporus	Pycnoporus	NNP
cord-001835-0s7ok4uw	4811	16	sanguineus	sanguineu	VBZ
cord-001835-0s7ok4uw	4811	17	Marta	Marta	NNP
cord-001835-0s7ok4uw	4811	18	Orlikowska	Orlikowska	NNP
cord-001835-0s7ok4uw	4811	19	1	1	CD
cord-001835-0s7ok4uw	4811	20	,	,	,
cord-001835-0s7ok4uw	4811	21	Grzegorz	Grzegorz	NNP
cord-001835-0s7ok4uw	4811	22	Bujacz	Bujacz	NNP
cord-001835-0s7ok4uw	4811	23	1	1	CD
cord-001835-0s7ok4uw	4811	24	1	1	CD
cord-001835-0s7ok4uw	4811	25	Institute	Institute	NNP
cord-001835-0s7ok4uw	4811	26	of	of	IN
cord-001835-0s7ok4uw	4811	27	Technical	Technical	NNP
cord-001835-0s7ok4uw	4811	28	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	4811	29	,	,	,
cord-001835-0s7ok4uw	4811	30	Lodz	Lodz	NNP
cord-001835-0s7ok4uw	4811	31	University	University	NNP
cord-001835-0s7ok4uw	4811	32	of	of	IN
cord-001835-0s7ok4uw	4811	33	Technology	Technology	NNP
cord-001835-0s7ok4uw	4811	34	,	,	,
cord-001835-0s7ok4uw	4811	35	Poland	Poland	NNP
cord-001835-0s7ok4uw	4811	36	Laccases	Laccases	NNP
cord-001835-0s7ok4uw	4811	37	(	(	-LRB-
cord-001835-0s7ok4uw	4811	38	EC	EC	NNP
cord-001835-0s7ok4uw	4811	39	1.10.3.2	1.10.3.2	NNP
cord-001835-0s7ok4uw	4811	40	,	,	,
cord-001835-0s7ok4uw	4811	41	benzenodiol	benzenodiol	NNP
cord-001835-0s7ok4uw	4811	42	oxygen	oxygen	NN
cord-001835-0s7ok4uw	4811	43	oxidoreductases	oxidoreductase	NNS
cord-001835-0s7ok4uw	4811	44	)	)	-RRB-
cord-001835-0s7ok4uw	4811	45	are	be	VBP
cord-001835-0s7ok4uw	4811	46	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4811	47	that	that	WDT
cord-001835-0s7ok4uw	4811	48	have	have	VBP
cord-001835-0s7ok4uw	4811	49	the	the	DT
cord-001835-0s7ok4uw	4811	50	ability	ability	NN
cord-001835-0s7ok4uw	4811	51	to	to	TO
cord-001835-0s7ok4uw	4811	52	catalyze	catalyze	VB
cord-001835-0s7ok4uw	4811	53	the	the	DT
cord-001835-0s7ok4uw	4811	54	oxidation	oxidation	NN
cord-001835-0s7ok4uw	4811	55	a	a	DT
cord-001835-0s7ok4uw	4811	56	wide	wide	JJ
cord-001835-0s7ok4uw	4811	57	spectrum	spectrum	NN
cord-001835-0s7ok4uw	4811	58	of	of	IN
cord-001835-0s7ok4uw	4811	59	phenolic	phenolic	JJ
cord-001835-0s7ok4uw	4811	60	compounds	compound	NNS
cord-001835-0s7ok4uw	4811	61	with	with	IN
cord-001835-0s7ok4uw	4811	62	the	the	DT
cord-001835-0s7ok4uw	4811	63	four	four	CD
cord-001835-0s7ok4uw	4811	64	-	-	HYPH
cord-001835-0s7ok4uw	4811	65	electron	electron	NN
cord-001835-0s7ok4uw	4811	66	reduction	reduction	NN
cord-001835-0s7ok4uw	4811	67	of	of	IN
cord-001835-0s7ok4uw	4811	68	molecular	molecular	JJ
cord-001835-0s7ok4uw	4811	69	oxygen	oxygen	NN
cord-001835-0s7ok4uw	4811	70	to	to	IN
cord-001835-0s7ok4uw	4811	71	water	water	NN
cord-001835-0s7ok4uw	4811	72	[	[	-LRB-
cord-001835-0s7ok4uw	4811	73	1	1	CD
cord-001835-0s7ok4uw	4811	74	]	]	-RRB-
cord-001835-0s7ok4uw	4811	75	.	.	.
cord-001835-0s7ok4uw	4812	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4812	2	has	have	VBZ
cord-001835-0s7ok4uw	4812	3	been	be	VBN
cord-001835-0s7ok4uw	4812	4	found	find	VBN
cord-001835-0s7ok4uw	4812	5	that	that	IN
cord-001835-0s7ok4uw	4812	6	the	the	DT
cord-001835-0s7ok4uw	4812	7	active	active	JJ
cord-001835-0s7ok4uw	4812	8	site	site	NN
cord-001835-0s7ok4uw	4812	9	is	be	VBZ
cord-001835-0s7ok4uw	4812	10	well	well	RB
cord-001835-0s7ok4uw	4812	11	conserved	conserve	VBN
cord-001835-0s7ok4uw	4812	12	in	in	IN
cord-001835-0s7ok4uw	4812	13	between	between	IN
cord-001835-0s7ok4uw	4812	14	laccases	laccase	NNS
cord-001835-0s7ok4uw	4812	15	from	from	IN
cord-001835-0s7ok4uw	4812	16	different	different	JJ
cord-001835-0s7ok4uw	4812	17	organisms	organism	NNS
cord-001835-0s7ok4uw	4812	18	.	.	.
cord-001835-0s7ok4uw	4813	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4813	2	contains	contain	VBZ
cord-001835-0s7ok4uw	4813	3	four	four	CD
cord-001835-0s7ok4uw	4813	4	copper	copper	NN
cord-001835-0s7ok4uw	4813	5	atoms	atom	NNS
cord-001835-0s7ok4uw	4813	6	:	:	:
cord-001835-0s7ok4uw	4813	7	one	one	CD
cord-001835-0s7ok4uw	4813	8	paramagnetic	paramagnetic	JJ
cord-001835-0s7ok4uw	4813	9	type	type	NN
cord-001835-0s7ok4uw	4813	10	1	1	CD
cord-001835-0s7ok4uw	4813	11	cooper	cooper	NNP
cord-001835-0s7ok4uw	4813	12	(	(	-LRB-
cord-001835-0s7ok4uw	4813	13	T1	T1	NNP
cord-001835-0s7ok4uw	4813	14	)	)	-RRB-
cord-001835-0s7ok4uw	4813	15	that	that	WDT
cord-001835-0s7ok4uw	4813	16	is	be	VBZ
cord-001835-0s7ok4uw	4813	17	responsible	responsible	JJ
cord-001835-0s7ok4uw	4813	18	for	for	IN
cord-001835-0s7ok4uw	4813	19	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4813	20	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	4813	21	blue	blue	JJ
cord-001835-0s7ok4uw	4813	22	color	color	NN
cord-001835-0s7ok4uw	4813	23	and	and	CC
cord-001835-0s7ok4uw	4813	24	where	where	WRB
cord-001835-0s7ok4uw	4813	25	the	the	DT
cord-001835-0s7ok4uw	4813	26	oxidation	oxidation	NN
cord-001835-0s7ok4uw	4813	27	of	of	IN
cord-001835-0s7ok4uw	4813	28	the	the	DT
cord-001835-0s7ok4uw	4813	29	reducing	reduce	VBG
cord-001835-0s7ok4uw	4813	30	substrate	substrate	NN
cord-001835-0s7ok4uw	4813	31	occurs	occur	VBZ
cord-001835-0s7ok4uw	4813	32	,	,	,
cord-001835-0s7ok4uw	4813	33	one	one	CD
cord-001835-0s7ok4uw	4813	34	type	type	NN
cord-001835-0s7ok4uw	4813	35	2	2	CD
cord-001835-0s7ok4uw	4813	36	cooper	cooper	NNP
cord-001835-0s7ok4uw	4813	37	(	(	-LRB-
cord-001835-0s7ok4uw	4813	38	T2	T2	NNP
cord-001835-0s7ok4uw	4813	39	)	)	-RRB-
cord-001835-0s7ok4uw	4813	40	and	and	CC
cord-001835-0s7ok4uw	4813	41	two	two	CD
cord-001835-0s7ok4uw	4813	42	type	type	NN
cord-001835-0s7ok4uw	4813	43	3	3	CD
cord-001835-0s7ok4uw	4813	44	coopers	cooper	NNS
cord-001835-0s7ok4uw	4813	45	(	(	-LRB-
cord-001835-0s7ok4uw	4813	46	T3	T3	NNP
cord-001835-0s7ok4uw	4813	47	)	)	-RRB-
cord-001835-0s7ok4uw	4813	48	that	that	WDT
cord-001835-0s7ok4uw	4813	49	conform	conform	VBP
cord-001835-0s7ok4uw	4813	50	a	a	DT
cord-001835-0s7ok4uw	4813	51	trinuclear	trinuclear	NN
cord-001835-0s7ok4uw	4813	52	cluster	cluster	NN
cord-001835-0s7ok4uw	4813	53	in	in	IN
cord-001835-0s7ok4uw	4813	54	which	which	WDT
cord-001835-0s7ok4uw	4813	55	molecular	molecular	JJ
cord-001835-0s7ok4uw	4813	56	oxygen	oxygen	NN
cord-001835-0s7ok4uw	4813	57	is	be	VBZ
cord-001835-0s7ok4uw	4813	58	reduced	reduce	VBN
cord-001835-0s7ok4uw	4813	59	to	to	IN
cord-001835-0s7ok4uw	4813	60	two	two	CD
cord-001835-0s7ok4uw	4813	61	molecules	molecule	NNS
cord-001835-0s7ok4uw	4813	62	of	of	IN
cord-001835-0s7ok4uw	4813	63	water	water	NN
cord-001835-0s7ok4uw	4813	64	[	[	-LRB-
cord-001835-0s7ok4uw	4813	65	2	2	CD
cord-001835-0s7ok4uw	4813	66	]	]	-RRB-
cord-001835-0s7ok4uw	4813	67	.	.	.
cord-001835-0s7ok4uw	4814	1	Laccases	Laccases	NNP
cord-001835-0s7ok4uw	4814	2	are	be	VBP
cord-001835-0s7ok4uw	4814	3	present	present	JJ
cord-001835-0s7ok4uw	4814	4	in	in	IN
cord-001835-0s7ok4uw	4814	5	many	many	JJ
cord-001835-0s7ok4uw	4814	6	different	different	JJ
cord-001835-0s7ok4uw	4814	7	species	specie	NNS
cord-001835-0s7ok4uw	4814	8	and	and	CC
cord-001835-0s7ok4uw	4814	9	they	-PRON-	PRP
cord-001835-0s7ok4uw	4814	10	have	have	VBP
cord-001835-0s7ok4uw	4814	11	been	be	VBN
cord-001835-0s7ok4uw	4814	12	isolated	isolate	VBN
cord-001835-0s7ok4uw	4814	13	from	from	IN
cord-001835-0s7ok4uw	4814	14	plants	plant	NNS
cord-001835-0s7ok4uw	4814	15	,	,	,
cord-001835-0s7ok4uw	4814	16	fungi	fungus	NNS
cord-001835-0s7ok4uw	4814	17	,	,	,
cord-001835-0s7ok4uw	4814	18	prokaryotes	prokaryote	NNS
cord-001835-0s7ok4uw	4814	19	,	,	,
cord-001835-0s7ok4uw	4814	20	and	and	CC
cord-001835-0s7ok4uw	4814	21	arthropods	arthropod	NNS
cord-001835-0s7ok4uw	4814	22	In	in	IN
cord-001835-0s7ok4uw	4814	23	most	most	JJS
cord-001835-0s7ok4uw	4814	24	cases	case	NNS
cord-001835-0s7ok4uw	4814	25	laccases	laccase	NNS
cord-001835-0s7ok4uw	4814	26	are	be	VBP
cord-001835-0s7ok4uw	4814	27	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	4814	28	glycoproteins	glycoprotein	NNS
cord-001835-0s7ok4uw	4814	29	of	of	IN
cord-001835-0s7ok4uw	4814	30	around	around	IN
cord-001835-0s7ok4uw	4814	31	500	500	CD
cord-001835-0s7ok4uw	4814	32	amino	amino	JJ
cord-001835-0s7ok4uw	4814	33	acids	acid	NNS
cord-001835-0s7ok4uw	4814	34	with	with	IN
cord-001835-0s7ok4uw	4814	35	molecular	molecular	JJ
cord-001835-0s7ok4uw	4814	36	weights	weight	NNS
cord-001835-0s7ok4uw	4814	37	in	in	IN
cord-001835-0s7ok4uw	4814	38	the	the	DT
cord-001835-0s7ok4uw	4814	39	range	range	NN
cord-001835-0s7ok4uw	4814	40	of	of	IN
cord-001835-0s7ok4uw	4814	41	60	60	CD
cord-001835-0s7ok4uw	4814	42	-	-	SYM
cord-001835-0s7ok4uw	4814	43	85	85	CD
cord-001835-0s7ok4uw	4814	44	kDa	kDa	NNS
cord-001835-0s7ok4uw	4814	45	.	.	.
cord-001835-0s7ok4uw	4815	1	The	the	DT
cord-001835-0s7ok4uw	4815	2	various	various	JJ
cord-001835-0s7ok4uw	4815	3	functions	function	NNS
cord-001835-0s7ok4uw	4815	4	carried	carry	VBN
cord-001835-0s7ok4uw	4815	5	out	out	RP
cord-001835-0s7ok4uw	4815	6	by	by	IN
cord-001835-0s7ok4uw	4815	7	those	those	DT
cord-001835-0s7ok4uw	4815	8	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4815	9	include	include	VBP
cord-001835-0s7ok4uw	4815	10	the	the	DT
cord-001835-0s7ok4uw	4815	11	antagonistic	antagonistic	JJ
cord-001835-0s7ok4uw	4815	12	ones	one	NNS
cord-001835-0s7ok4uw	4815	13	such	such	JJ
cord-001835-0s7ok4uw	4815	14	as	as	IN
cord-001835-0s7ok4uw	4815	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4815	16	involvement	involvement	NN
cord-001835-0s7ok4uw	4815	17	in	in	IN
cord-001835-0s7ok4uw	4815	18	lignin	lignin	NN
cord-001835-0s7ok4uw	4815	19	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	4815	20	(	(	-LRB-
cord-001835-0s7ok4uw	4815	21	in	in	IN
cord-001835-0s7ok4uw	4815	22	plants	plant	NNS
cord-001835-0s7ok4uw	4815	23	)	)	-RRB-
cord-001835-0s7ok4uw	4815	24	,	,	,
cord-001835-0s7ok4uw	4815	25	lignin	lignin	NN
cord-001835-0s7ok4uw	4815	26	degradation	degradation	NN
cord-001835-0s7ok4uw	4815	27	,	,	,
cord-001835-0s7ok4uw	4815	28	pigment	pigment	NN
cord-001835-0s7ok4uw	4815	29	production	production	NN
cord-001835-0s7ok4uw	4815	30	,	,	,
cord-001835-0s7ok4uw	4815	31	fruiting	fruit	VBG
cord-001835-0s7ok4uw	4815	32	body	body	NN
cord-001835-0s7ok4uw	4815	33	formation	formation	NN
cord-001835-0s7ok4uw	4815	34	,	,	,
cord-001835-0s7ok4uw	4815	35	pathogenesis	pathogenesis	NN
cord-001835-0s7ok4uw	4815	36	(	(	-LRB-
cord-001835-0s7ok4uw	4815	37	in	in	IN
cord-001835-0s7ok4uw	4815	38	fungi	fungus	NNS
cord-001835-0s7ok4uw	4815	39	)	)	-RRB-
cord-001835-0s7ok4uw	4815	40	and	and	CC
cord-001835-0s7ok4uw	4815	41	spore	spore	NN
cord-001835-0s7ok4uw	4815	42	protection	protection	NN
cord-001835-0s7ok4uw	4815	43	against	against	IN
cord-001835-0s7ok4uw	4815	44	UV	uv	NN
cord-001835-0s7ok4uw	4815	45	light	light	NN
cord-001835-0s7ok4uw	4815	46	(	(	-LRB-
cord-001835-0s7ok4uw	4815	47	in	in	IN
cord-001835-0s7ok4uw	4815	48	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	4815	49	)	)	-RRB-
cord-001835-0s7ok4uw	4815	50	[	[	-LRB-
cord-001835-0s7ok4uw	4815	51	1	1	CD
cord-001835-0s7ok4uw	4815	52	,	,	,
cord-001835-0s7ok4uw	4815	53	3	3	CD
cord-001835-0s7ok4uw	4815	54	]	]	-RRB-
cord-001835-0s7ok4uw	4815	55	.	.	.
cord-001835-0s7ok4uw	4816	1	The	the	DT
cord-001835-0s7ok4uw	4816	2	diversified	diversified	JJ
cord-001835-0s7ok4uw	4816	3	functions	function	NNS
cord-001835-0s7ok4uw	4816	4	of	of	IN
cord-001835-0s7ok4uw	4816	5	laccases	laccase	NNS
cord-001835-0s7ok4uw	4816	6	make	make	VBP
cord-001835-0s7ok4uw	4816	7	them	-PRON-	PRP
cord-001835-0s7ok4uw	4816	8	an	an	DT
cord-001835-0s7ok4uw	4816	9	interesting	interesting	JJ
cord-001835-0s7ok4uw	4816	10	enzyme	enzyme	NN
cord-001835-0s7ok4uw	4816	11	for	for	IN
cord-001835-0s7ok4uw	4816	12	study	study	NN
cord-001835-0s7ok4uw	4816	13	from	from	IN
cord-001835-0s7ok4uw	4816	14	the	the	DT
cord-001835-0s7ok4uw	4816	15	point	point	NN
cord-001835-0s7ok4uw	4816	16	of	of	IN
cord-001835-0s7ok4uw	4816	17	view	view	NN
cord-001835-0s7ok4uw	4816	18	of	of	IN
cord-001835-0s7ok4uw	4816	19	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4816	20	structure	structure	NN
cord-001835-0s7ok4uw	4816	21	,	,	,
cord-001835-0s7ok4uw	4816	22	function	function	NN
cord-001835-0s7ok4uw	4816	23	and	and	CC
cord-001835-0s7ok4uw	4816	24	application	application	NN
cord-001835-0s7ok4uw	4816	25	.	.	.
cord-001835-0s7ok4uw	4817	1	Laccases	Laccases	NNP
cord-001835-0s7ok4uw	4817	2	of	of	IN
cord-001835-0s7ok4uw	4817	3	white	white	JJ
cord-001835-0s7ok4uw	4817	4	-	-	HYPH
cord-001835-0s7ok4uw	4817	5	rot	rot	NN
cord-001835-0s7ok4uw	4817	6	fungi	fungus	NNS
cord-001835-0s7ok4uw	4817	7	(	(	-LRB-
cord-001835-0s7ok4uw	4817	8	WRF	WRF	NNP
cord-001835-0s7ok4uw	4817	9	)	)	-RRB-
cord-001835-0s7ok4uw	4817	10	are	be	VBP
cord-001835-0s7ok4uw	4817	11	of	of	IN
cord-001835-0s7ok4uw	4817	12	special	special	JJ
cord-001835-0s7ok4uw	4817	13	interest	interest	NN
cord-001835-0s7ok4uw	4817	14	because	because	IN
cord-001835-0s7ok4uw	4817	15	one	one	CD
cord-001835-0s7ok4uw	4817	16	of	of	IN
cord-001835-0s7ok4uw	4817	17	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4817	18	role	role	NN
cord-001835-0s7ok4uw	4817	19	is	be	VBZ
cord-001835-0s7ok4uw	4817	20	to	to	TO
cord-001835-0s7ok4uw	4817	21	degrade	degrade	VB
cord-001835-0s7ok4uw	4817	22	lignin	lignin	NN
cord-001835-0s7ok4uw	4817	23	and	and	CC
cord-001835-0s7ok4uw	4817	24	most	most	JJS
cord-001835-0s7ok4uw	4817	25	of	of	IN
cord-001835-0s7ok4uw	4817	26	them	-PRON-	PRP
cord-001835-0s7ok4uw	4817	27	are	be	VBP
cord-001835-0s7ok4uw	4817	28	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	4817	29	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4817	30	helping	help	VBG
cord-001835-0s7ok4uw	4817	31	purification	purification	NN
cord-001835-0s7ok4uw	4817	32	procedures	procedure	NNS
cord-001835-0s7ok4uw	4817	33	[	[	-LRB-
cord-001835-0s7ok4uw	4817	34	1	1	CD
cord-001835-0s7ok4uw	4817	35	]	]	-RRB-
cord-001835-0s7ok4uw	4817	36	.	.	.
cord-001835-0s7ok4uw	4818	1	During	during	IN
cord-001835-0s7ok4uw	4818	2	the	the	DT
cord-001835-0s7ok4uw	4818	3	last	last	JJ
cord-001835-0s7ok4uw	4818	4	two	two	CD
cord-001835-0s7ok4uw	4818	5	decades	decade	NNS
cord-001835-0s7ok4uw	4818	6	,	,	,
cord-001835-0s7ok4uw	4818	7	there	there	EX
cord-001835-0s7ok4uw	4818	8	has	have	VBZ
cord-001835-0s7ok4uw	4818	9	been	be	VBN
cord-001835-0s7ok4uw	4818	10	an	an	DT
cord-001835-0s7ok4uw	4818	11	increasing	increase	VBG
cord-001835-0s7ok4uw	4818	12	interest	interest	NN
cord-001835-0s7ok4uw	4818	13	in	in	IN
cord-001835-0s7ok4uw	4818	14	the	the	DT
cord-001835-0s7ok4uw	4818	15	genus	genus	NN
cord-001835-0s7ok4uw	4818	16	Pycnoporus	Pycnoporus	NNP
cord-001835-0s7ok4uw	4818	17	for	for	IN
cord-001835-0s7ok4uw	4818	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4818	19	ability	ability	NN
cord-001835-0s7ok4uw	4818	20	to	to	TO
cord-001835-0s7ok4uw	4818	21	overproduce	overproduce	VB
cord-001835-0s7ok4uw	4818	22	high	high	JJ
cord-001835-0s7ok4uw	4818	23	redox	redox	NN
cord-001835-0s7ok4uw	4818	24	potential	potential	NN
cord-001835-0s7ok4uw	4818	25	laccases	laccase	NNS
cord-001835-0s7ok4uw	4818	26	as	as	IN
cord-001835-0s7ok4uw	4818	27	the	the	DT
cord-001835-0s7ok4uw	4818	28	ligninolytic	ligninolytic	JJ
cord-001835-0s7ok4uw	4818	29	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4818	30	.	.	.
cord-001835-0s7ok4uw	4819	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4819	2	present	present	VBP
cord-001835-0s7ok4uw	4819	3	the	the	DT
cord-001835-0s7ok4uw	4819	4	crystal	crystal	NN
cord-001835-0s7ok4uw	4819	5	structures	structure	NNS
cord-001835-0s7ok4uw	4819	6	of	of	IN
cord-001835-0s7ok4uw	4819	7	two	two	CD
cord-001835-0s7ok4uw	4819	8	thermostable	thermostable	JJ
cord-001835-0s7ok4uw	4819	9	lacasses	lacasse	NNS
cord-001835-0s7ok4uw	4819	10	produced	produce	VBN
cord-001835-0s7ok4uw	4819	11	by	by	IN
cord-001835-0s7ok4uw	4819	12	strain	strain	NN
cord-001835-0s7ok4uw	4819	13	Pycnoporus	Pycnoporus	NNP
cord-001835-0s7ok4uw	4819	14	sanguineus	sanguineu	VBD
cord-001835-0s7ok4uw	4819	15	CS43	CS43	NNP
cord-001835-0s7ok4uw	4819	16	(	(	-LRB-
cord-001835-0s7ok4uw	4819	17	LacI	LacI	NNP
cord-001835-0s7ok4uw	4819	18	and	and	CC
cord-001835-0s7ok4uw	4819	19	LacII	LacII	NNP
cord-001835-0s7ok4uw	4819	20	)	)	-RRB-
cord-001835-0s7ok4uw	4819	21	.	.	.
cord-001835-0s7ok4uw	4820	1	The	the	DT
cord-001835-0s7ok4uw	4820	2	molecular	molecular	JJ
cord-001835-0s7ok4uw	4820	3	weights	weight	NNS
cord-001835-0s7ok4uw	4820	4	of	of	IN
cord-001835-0s7ok4uw	4820	5	LacI	LacI	NNP
cord-001835-0s7ok4uw	4820	6	and	and	CC
cord-001835-0s7ok4uw	4820	7	LacII	LacII	NNP
cord-001835-0s7ok4uw	4820	8	,	,	,
cord-001835-0s7ok4uw	4820	9	determined	determine	VBN
cord-001835-0s7ok4uw	4820	10	by	by	IN
cord-001835-0s7ok4uw	4820	11	SDS	sds	NN
cord-001835-0s7ok4uw	4820	12	-	-	HYPH
cord-001835-0s7ok4uw	4820	13	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	4820	14	,	,	,
cord-001835-0s7ok4uw	4820	15	is	be	VBZ
cord-001835-0s7ok4uw	4820	16	68	68	CD
cord-001835-0s7ok4uw	4820	17	and	and	CC
cord-001835-0s7ok4uw	4820	18	66	66	CD
cord-001835-0s7ok4uw	4820	19	kDa	kDa	NNS
cord-001835-0s7ok4uw	4820	20	,	,	,
cord-001835-0s7ok4uw	4820	21	respectively	respectively	RB
cord-001835-0s7ok4uw	4820	22	[	[	-LRB-
cord-001835-0s7ok4uw	4820	23	3	3	CD
cord-001835-0s7ok4uw	4820	24	]	]	-RRB-
cord-001835-0s7ok4uw	4820	25	.	.	.
cord-001835-0s7ok4uw	4821	1	Both	both	DT
cord-001835-0s7ok4uw	4821	2	isoforms	isoform	NNS
cord-001835-0s7ok4uw	4821	3	shows	show	VBZ
cord-001835-0s7ok4uw	4821	4	high	high	JJ
cord-001835-0s7ok4uw	4821	5	amino	amino	NN
cord-001835-0s7ok4uw	4821	6	acids	acid	NNS
cord-001835-0s7ok4uw	4821	7	sequence	sequence	NN
cord-001835-0s7ok4uw	4821	8	similarity	similarity	NN
cord-001835-0s7ok4uw	4821	9	(	(	-LRB-
cord-001835-0s7ok4uw	4821	10	91	91	CD
cord-001835-0s7ok4uw	4821	11	%	%	NN
cord-001835-0s7ok4uw	4821	12	)	)	-RRB-
cord-001835-0s7ok4uw	4821	13	between	between	IN
cord-001835-0s7ok4uw	4821	14	them	-PRON-	PRP
cord-001835-0s7ok4uw	4821	15	and	and	CC
cord-001835-0s7ok4uw	4821	16	high	high	JJ
cord-001835-0s7ok4uw	4821	17	thermal	thermal	JJ
cord-001835-0s7ok4uw	4821	18	stability	stability	NN
cord-001835-0s7ok4uw	4821	19	,	,	,
cord-001835-0s7ok4uw	4821	20	at	at	IN
cord-001835-0s7ok4uw	4821	21	508C	508c	CD
cord-001835-0s7ok4uw	4822	1	and	and	CC
cord-001835-0s7ok4uw	4822	2	608C.	608c.	LS
cord-001835-0s7ok4uw	4822	3	They	-PRON-	PRP
cord-001835-0s7ok4uw	4822	4	remained	remain	VBD
cord-001835-0s7ok4uw	4822	5	active	active	JJ
cord-001835-0s7ok4uw	4822	6	at	at	IN
cord-001835-0s7ok4uw	4822	7	high	high	JJ
cord-001835-0s7ok4uw	4822	8	concentration	concentration	NN
cord-001835-0s7ok4uw	4822	9	of	of	IN
cord-001835-0s7ok4uw	4822	10	organic	organic	JJ
cord-001835-0s7ok4uw	4822	11	solvent	solvent	NN
cord-001835-0s7ok4uw	4822	12	(	(	-LRB-
cord-001835-0s7ok4uw	4822	13	acetonitrile	acetonitrile	NN
cord-001835-0s7ok4uw	4822	14	,	,	,
cord-001835-0s7ok4uw	4822	15	ethanol	ethanol	NN
cord-001835-0s7ok4uw	4822	16	or	or	CC
cord-001835-0s7ok4uw	4822	17	acetone	acetone	NN
cord-001835-0s7ok4uw	4822	18	)	)	-RRB-
cord-001835-0s7ok4uw	4822	19	.	.	.
cord-001835-0s7ok4uw	4823	1	The	the	DT
cord-001835-0s7ok4uw	4823	2	unique	unique	JJ
cord-001835-0s7ok4uw	4823	3	properties	property	NNS
cord-001835-0s7ok4uw	4823	4	make	make	VBP
cord-001835-0s7ok4uw	4823	5	them	-PRON-	PRP
cord-001835-0s7ok4uw	4823	6	promising	promising	JJ
cord-001835-0s7ok4uw	4823	7	candidates	candidate	NNS
cord-001835-0s7ok4uw	4823	8	for	for	IN
cord-001835-0s7ok4uw	4823	9	industrial	industrial	JJ
cord-001835-0s7ok4uw	4823	10	applications	application	NNS
cord-001835-0s7ok4uw	4823	11	in	in	IN
cord-001835-0s7ok4uw	4823	12	wasterwater	wasterwater	JJ
cord-001835-0s7ok4uw	4823	13	treatment	treatment	NN
cord-001835-0s7ok4uw	4823	14	.	.	.
cord-001835-0s7ok4uw	4824	1	LacI	LacI	NNP
cord-001835-0s7ok4uw	4824	2	exerted	exert	VBD
cord-001835-0s7ok4uw	4824	3	a	a	DT
cord-001835-0s7ok4uw	4824	4	higher	high	JJR
cord-001835-0s7ok4uw	4824	5	thermal	thermal	JJ
cord-001835-0s7ok4uw	4824	6	and	and	CC
cord-001835-0s7ok4uw	4824	7	pH	ph	NN
cord-001835-0s7ok4uw	4824	8	stability	stability	NN
cord-001835-0s7ok4uw	4824	9	,	,	,
cord-001835-0s7ok4uw	4824	10	tolerance	tolerance	NN
cord-001835-0s7ok4uw	4824	11	against	against	IN
cord-001835-0s7ok4uw	4824	12	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4824	13	and	and	CC
cord-001835-0s7ok4uw	4824	14	was	be	VBD
cord-001835-0s7ok4uw	4824	15	a	a	DT
cord-001835-0s7ok4uw	4824	16	more	more	RBR
cord-001835-0s7ok4uw	4824	17	efficient	efficient	JJ
cord-001835-0s7ok4uw	4824	18	catalyst	catalyst	NN
cord-001835-0s7ok4uw	4824	19	for	for	IN
cord-001835-0s7ok4uw	4824	20	ABTS	ABTS	NNP
cord-001835-0s7ok4uw	4824	21	and	and	CC
cord-001835-0s7ok4uw	4824	22	DMP	DMP	NNP
cord-001835-0s7ok4uw	4824	23	(	(	-LRB-
cord-001835-0s7ok4uw	4824	24	laccases	laccases	NNP
cord-001835-0s7ok4uw	4824	25	substrate	substrate	NN
cord-001835-0s7ok4uw	4824	26	)	)	-RRB-
cord-001835-0s7ok4uw	4825	1	then	then	RB
cord-001835-0s7ok4uw	4825	2	LacII	LacII	NNP
cord-001835-0s7ok4uw	4825	3	[	[	-LRB-
cord-001835-0s7ok4uw	4825	4	3	3	CD
cord-001835-0s7ok4uw	4825	5	]	]	-RRB-
cord-001835-0s7ok4uw	4825	6	.	.	.
cord-001835-0s7ok4uw	4826	1	Based	base	VBN
cord-001835-0s7ok4uw	4826	2	on	on	IN
cord-001835-0s7ok4uw	4826	3	the	the	DT
cord-001835-0s7ok4uw	4826	4	structures	structure	NNS
cord-001835-0s7ok4uw	4826	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4826	6	would	would	MD
cord-001835-0s7ok4uw	4826	7	like	like	VB
cord-001835-0s7ok4uw	4826	8	to	to	TO
cord-001835-0s7ok4uw	4826	9	understand	understand	VB
cord-001835-0s7ok4uw	4826	10	the	the	DT
cord-001835-0s7ok4uw	4826	11	isoforms	isoform	NNS
cord-001835-0s7ok4uw	4826	12	differences	difference	NNS
cord-001835-0s7ok4uw	4826	13	that	that	WDT
cord-001835-0s7ok4uw	4826	14	confers	confer	VBZ
cord-001835-0s7ok4uw	4826	15	LacI	LacI	NNP
cord-001835-0s7ok4uw	4826	16	a	a	DT
cord-001835-0s7ok4uw	4826	17	markedly	markedly	RB
cord-001835-0s7ok4uw	4826	18	better	well	JJR
cord-001835-0s7ok4uw	4826	19	performance	performance	NN
cord-001835-0s7ok4uw	4826	20	than	than	IN
cord-001835-0s7ok4uw	4826	21	LacII	LacII	NNP
cord-001835-0s7ok4uw	4826	22	in	in	IN
cord-001835-0s7ok4uw	4826	23	pH	pH	NNP
cord-001835-0s7ok4uw	4826	24	and	and	CC
cord-001835-0s7ok4uw	4826	25	thermal	thermal	JJ
cord-001835-0s7ok4uw	4826	26	stability	stability	NN
cord-001835-0s7ok4uw	4826	27	as	as	RB
cord-001835-0s7ok4uw	4826	28	well	well	RB
cord-001835-0s7ok4uw	4826	29	as	as	IN
cord-001835-0s7ok4uw	4826	30	better	well	JJR
cord-001835-0s7ok4uw	4826	31	resistance	resistance	NN
cord-001835-0s7ok4uw	4826	32	to	to	IN
cord-001835-0s7ok4uw	4826	33	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4826	34	.	.	.
cord-001835-0s7ok4uw	4826	35	 	 	_SP
cord-001835-0s7ok4uw	4827	1	Analysis	analysis	NN
cord-001835-0s7ok4uw	4827	2	of	of	IN
cord-001835-0s7ok4uw	4827	3	liver	liver	NN
cord-001835-0s7ok4uw	4827	4	proteome	proteome	NN
cord-001835-0s7ok4uw	4827	5	in	in	IN
cord-001835-0s7ok4uw	4827	6	cystathionine	cystathionine	NN
cord-001835-0s7ok4uw	4827	7	ß	ß	NN
cord-001835-0s7ok4uw	4827	8	-	-	HYPH
cord-001835-0s7ok4uw	4827	9	synthase	synthase	NN
cord-001835-0s7ok4uw	4827	10	deficient	deficient	JJ
cord-001835-0s7ok4uw	4827	11	mice	mouse	NNS
cord-001835-0s7ok4uw	4827	12	using	use	VBG
cord-001835-0s7ok4uw	4827	13	2D	2D	VBN
cord-001835-0s7ok4uw	4827	14	IEF	IEF	NNP
cord-001835-0s7ok4uw	4827	15	/	/	SYM
cord-001835-0s7ok4uw	4827	16	SDS	SDS	NNP
cord-001835-0s7ok4uw	4827	17	-	-	HYPH
cord-001835-0s7ok4uw	4827	18	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	4827	19	gel	gel	NN
cord-001835-0s7ok4uw	4827	20	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	4827	21	,	,	,
cord-001835-0s7ok4uw	4827	22	MALDI	MALDI	NNP
cord-001835-0s7ok4uw	4827	23	-	-	HYPH
cord-001835-0s7ok4uw	4827	24	TOF	TOF	NNP
cord-001835-0s7ok4uw	4827	25	mass	mass	NN
cord-001835-0s7ok4uw	4827	26	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4827	27	,	,	,
cord-001835-0s7ok4uw	4827	28	and	and	CC
cord-001835-0s7ok4uw	4827	29	label	label	NN
cord-001835-0s7ok4uw	4827	30	-	-	HYPH
cord-001835-0s7ok4uw	4827	31	free	free	JJ
cord-001835-0s7ok4uw	4827	32	based	base	VBN
cord-001835-0s7ok4uw	4827	33	relative	relative	JJ
cord-001835-0s7ok4uw	4827	34	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	4827	35	proteomics	proteomic	NNS
cord-001835-0s7ok4uw	4827	36	Izabela	Izabela	NNP
cord-001835-0s7ok4uw	4827	37	Bieli	Bieli	NNP
cord-001835-0s7ok4uw	4827	38	nska	nska	NNP
cord-001835-0s7ok4uw	4827	39	1	1	CD
cord-001835-0s7ok4uw	4827	40	,	,	,
cord-001835-0s7ok4uw	4827	41	Łukasz	Łukasz	NNP
cord-001835-0s7ok4uw	4827	42	Marczak	Marczak	NNP
cord-001835-0s7ok4uw	4827	43	1	1	CD
cord-001835-0s7ok4uw	4828	1	,	,	,
cord-001835-0s7ok4uw	4828	2	Hieronim	Hieronim	NNP
cord-001835-0s7ok4uw	4828	3	Jakubowski	Jakubowski	NNP
cord-001835-0s7ok4uw	4828	4	1,2	1,2	CD
cord-001835-0s7ok4uw	4828	5	1	1	CD
cord-001835-0s7ok4uw	4828	6	Institute	Institute	NNP
cord-001835-0s7ok4uw	4828	7	of	of	IN
cord-001835-0s7ok4uw	4828	8	Bioorganic	Bioorganic	NNP
cord-001835-0s7ok4uw	4828	9	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	4828	10	,	,	,
cord-001835-0s7ok4uw	4828	11	Polish	Polish	NNP
cord-001835-0s7ok4uw	4828	12	Academy	Academy	NNP
cord-001835-0s7ok4uw	4828	13	of	of	IN
cord-001835-0s7ok4uw	4828	14	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	4828	15	,	,	,
cord-001835-0s7ok4uw	4828	16	2	2	CD
cord-001835-0s7ok4uw	4828	17	Rutgers	Rutgers	NNP
cord-001835-0s7ok4uw	4828	18	University	University	NNP
cord-001835-0s7ok4uw	4828	19	,	,	,
cord-001835-0s7ok4uw	4828	20	New	New	NNP
cord-001835-0s7ok4uw	4828	21	Jersey	Jersey	NNP
cord-001835-0s7ok4uw	4828	22	Medical	Medical	NNP
cord-001835-0s7ok4uw	4828	23	School	School	NNP
cord-001835-0s7ok4uw	4828	24	Homocysteine	Homocysteine	NNP
cord-001835-0s7ok4uw	4828	25	(	(	-LRB-
cord-001835-0s7ok4uw	4828	26	Hcy	Hcy	NNP
cord-001835-0s7ok4uw	4828	27	)	)	-RRB-
cord-001835-0s7ok4uw	4828	28	arises	arise	VBZ
cord-001835-0s7ok4uw	4828	29	from	from	IN
cord-001835-0s7ok4uw	4828	30	the	the	DT
cord-001835-0s7ok4uw	4828	31	metabolism	metabolism	NN
cord-001835-0s7ok4uw	4828	32	of	of	IN
cord-001835-0s7ok4uw	4828	33	the	the	DT
cord-001835-0s7ok4uw	4828	34	essential	essential	JJ
cord-001835-0s7ok4uw	4828	35	dietary	dietary	JJ
cord-001835-0s7ok4uw	4828	36	protein	protein	NN
cord-001835-0s7ok4uw	4828	37	amino	amino	NN
cord-001835-0s7ok4uw	4828	38	acid	acid	NN
cord-001835-0s7ok4uw	4828	39	methionine	methionine	NN
cord-001835-0s7ok4uw	4828	40	.	.	.
cord-001835-0s7ok4uw	4829	1	Levels	level	NNS
cord-001835-0s7ok4uw	4829	2	of	of	IN
cord-001835-0s7ok4uw	4829	3	Hcy	Hcy	NNP
cord-001835-0s7ok4uw	4829	4	are	be	VBP
cord-001835-0s7ok4uw	4829	5	regulated	regulate	VBN
cord-001835-0s7ok4uw	4829	6	by	by	IN
cord-001835-0s7ok4uw	4829	7	remethylation	remethylation	NN
cord-001835-0s7ok4uw	4829	8	to	to	IN
cord-001835-0s7ok4uw	4829	9	Met	Met	NNP
cord-001835-0s7ok4uw	4829	10	and	and	CC
cord-001835-0s7ok4uw	4829	11	transsulfuration	transsulfuration	NN
cord-001835-0s7ok4uw	4829	12	to	to	IN
cord-001835-0s7ok4uw	4829	13	Cys	Cys	NNP
cord-001835-0s7ok4uw	4829	14	.	.	.
cord-001835-0s7ok4uw	4830	1	Cystathionine	Cystathionine	NNP
cord-001835-0s7ok4uw	4830	2	bsynthase	bsynthase	NN
cord-001835-0s7ok4uw	4830	3	(	(	-LRB-
cord-001835-0s7ok4uw	4830	4	CBS	CBS	NNP
cord-001835-0s7ok4uw	4830	5	)	)	-RRB-
cord-001835-0s7ok4uw	4830	6	catalyzes	catalyze	VBZ
cord-001835-0s7ok4uw	4830	7	the	the	DT
cord-001835-0s7ok4uw	4830	8	conversion	conversion	NN
cord-001835-0s7ok4uw	4830	9	of	of	IN
cord-001835-0s7ok4uw	4830	10	homocysteine	homocysteine	NN
cord-001835-0s7ok4uw	4830	11	to	to	IN
cord-001835-0s7ok4uw	4830	12	cystathionine	cystathionine	VB
cord-001835-0s7ok4uw	4830	13	(	(	-LRB-
cord-001835-0s7ok4uw	4830	14	first	first	JJ
cord-001835-0s7ok4uw	4830	15	step	step	NN
cord-001835-0s7ok4uw	4830	16	of	of	IN
cord-001835-0s7ok4uw	4830	17	transsulfuration	transsulfuration	NN
cord-001835-0s7ok4uw	4830	18	reaction	reaction	NN
cord-001835-0s7ok4uw	4830	19	)	)	-RRB-
cord-001835-0s7ok4uw	4830	20	.	.	.
cord-001835-0s7ok4uw	4831	1	Human	human	JJ
cord-001835-0s7ok4uw	4831	2	CBS	CBS	NNP
cord-001835-0s7ok4uw	4831	3	deficiency	deficiency	NN
cord-001835-0s7ok4uw	4831	4	is	be	VBZ
cord-001835-0s7ok4uw	4831	5	a	a	DT
cord-001835-0s7ok4uw	4831	6	recessive	recessive	JJ
cord-001835-0s7ok4uw	4831	7	inborn	inborn	JJ
cord-001835-0s7ok4uw	4831	8	error	error	NN
cord-001835-0s7ok4uw	4831	9	of	of	IN
cord-001835-0s7ok4uw	4831	10	homocysteine	homocysteine	JJ
cord-001835-0s7ok4uw	4831	11	metabolism	metabolism	NN
cord-001835-0s7ok4uw	4831	12	that	that	WDT
cord-001835-0s7ok4uw	4831	13	casues	casue	VBZ
cord-001835-0s7ok4uw	4831	14	severe	severe	JJ
cord-001835-0s7ok4uw	4831	15	hyperhomocysteinemia	hyperhomocysteinemia	NN
cord-001835-0s7ok4uw	4831	16	(	(	-LRB-
cord-001835-0s7ok4uw	4831	17	HHcy	HHcy	NNP
cord-001835-0s7ok4uw	4831	18	)	)	-RRB-
cord-001835-0s7ok4uw	4831	19	and	and	CC
cord-001835-0s7ok4uw	4831	20	diverse	diverse	JJ
cord-001835-0s7ok4uw	4831	21	clinical	clinical	JJ
cord-001835-0s7ok4uw	4831	22	manifestations	manifestation	NNS
cord-001835-0s7ok4uw	4831	23	,	,	,
cord-001835-0s7ok4uw	4831	24	including	include	VBG
cord-001835-0s7ok4uw	4831	25	fatty	fatty	JJ
cord-001835-0s7ok4uw	4831	26	liver	liver	NN
cord-001835-0s7ok4uw	4831	27	disease	disease	NN
cord-001835-0s7ok4uw	4831	28	[	[	-LRB-
cord-001835-0s7ok4uw	4831	29	1	1	CD
cord-001835-0s7ok4uw	4831	30	]	]	-RRB-
cord-001835-0s7ok4uw	4831	31	.	.	.
cord-001835-0s7ok4uw	4832	1	Although	although	IN
cord-001835-0s7ok4uw	4832	2	the	the	DT
cord-001835-0s7ok4uw	4832	3	causes	cause	NNS
cord-001835-0s7ok4uw	4832	4	of	of	IN
cord-001835-0s7ok4uw	4832	5	fatty	fatty	JJ
cord-001835-0s7ok4uw	4832	6	liver	liver	NN
cord-001835-0s7ok4uw	4832	7	disease	disease	NN
cord-001835-0s7ok4uw	4832	8	in	in	IN
cord-001835-0s7ok4uw	4832	9	CBS	CBS	NNP
cord-001835-0s7ok4uw	4832	10	deficiency	deficiency	NN
cord-001835-0s7ok4uw	4832	11	have	have	VBP
cord-001835-0s7ok4uw	4832	12	been	be	VBN
cord-001835-0s7ok4uw	4832	13	studied	study	VBN
cord-001835-0s7ok4uw	4832	14	the	the	DT
cord-001835-0s7ok4uw	4832	15	underlying	underlying	JJ
cord-001835-0s7ok4uw	4832	16	mechanism	mechanism	NN
cord-001835-0s7ok4uw	4832	17	is	be	VBZ
cord-001835-0s7ok4uw	4832	18	not	not	RB
cord-001835-0s7ok4uw	4832	19	understood	understand	VBN
cord-001835-0s7ok4uw	4832	20	.	.	.
cord-001835-0s7ok4uw	4833	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4833	2	hypothesize	hypothesize	VBP
cord-001835-0s7ok4uw	4833	3	that	that	IN
cord-001835-0s7ok4uw	4833	4	CBS	CBS	NNP
cord-001835-0s7ok4uw	4833	5	deficiency	deficiency	NN
cord-001835-0s7ok4uw	4833	6	induces	induce	VBZ
cord-001835-0s7ok4uw	4833	7	changes	change	NNS
cord-001835-0s7ok4uw	4833	8	in	in	IN
cord-001835-0s7ok4uw	4833	9	gene	gene	NN
cord-001835-0s7ok4uw	4833	10	expression	expression	NN
cord-001835-0s7ok4uw	4833	11	that	that	WDT
cord-001835-0s7ok4uw	4833	12	could	could	MD
cord-001835-0s7ok4uw	4833	13	impair	impair	VB
cord-001835-0s7ok4uw	4833	14	liver	liver	NN
cord-001835-0s7ok4uw	4833	15	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	4833	16	.	.	.
cord-001835-0s7ok4uw	4834	1	To	to	TO
cord-001835-0s7ok4uw	4834	2	test	test	VB
cord-001835-0s7ok4uw	4834	3	this	this	DT
cord-001835-0s7ok4uw	4834	4	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	4834	5	and	and	CC
cord-001835-0s7ok4uw	4834	6	gain	gain	VB
cord-001835-0s7ok4uw	4834	7	insight	insight	NN
cord-001835-0s7ok4uw	4834	8	into	into	IN
cord-001835-0s7ok4uw	4834	9	hepatic	hepatic	JJ
cord-001835-0s7ok4uw	4834	10	functions	function	NNS
cord-001835-0s7ok4uw	4834	11	of	of	IN
cord-001835-0s7ok4uw	4834	12	Cbs	Cbs	NNP
cord-001835-0s7ok4uw	4834	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	4834	14	analyzed	analyze	VBD
cord-001835-0s7ok4uw	4834	15	the	the	DT
cord-001835-0s7ok4uw	4834	16	liver	liver	NN
cord-001835-0s7ok4uw	4834	17	proteome	proteome	NN
cord-001835-0s7ok4uw	4834	18	of	of	IN
cord-001835-0s7ok4uw	4834	19	Cbs	Cbs	NNP
cord-001835-0s7ok4uw	4834	20	-/-and	-/-and	.
cord-001835-0s7ok4uw	4835	1	Cbs	Cbs	NNP
cord-001835-0s7ok4uw	4835	2	1/1	1/1	CD
cord-001835-0s7ok4uw	4835	3	mice	mouse	NNS
cord-001835-0s7ok4uw	4835	4	[	[	-LRB-
cord-001835-0s7ok4uw	4835	5	2,3	2,3	CD
cord-001835-0s7ok4uw	4835	6	]	]	-RRB-
cord-001835-0s7ok4uw	4836	1	Using	use	VBG
cord-001835-0s7ok4uw	4836	2	2D	2D	NNP
cord-001835-0s7ok4uw	4836	3	IEF	IEF	NNP
cord-001835-0s7ok4uw	4836	4	/	/	SYM
cord-001835-0s7ok4uw	4836	5	SDS	SDS	NNP
cord-001835-0s7ok4uw	4836	6	-	-	HYPH
cord-001835-0s7ok4uw	4836	7	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	4836	8	gel	gel	NN
cord-001835-0s7ok4uw	4836	9	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	4836	10	and	and	CC
cord-001835-0s7ok4uw	4836	11	MALDI	MALDI	NNP
cord-001835-0s7ok4uw	4836	12	-	-	HYPH
cord-001835-0s7ok4uw	4836	13	TOF	TOF	NNP
cord-001835-0s7ok4uw	4836	14	mass	mass	NN
cord-001835-0s7ok4uw	4836	15	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4837	1	(	(	-LRB-
cord-001835-0s7ok4uw	4837	2	n514	n514	NNP
cord-001835-0s7ok4uw	4837	3	)	)	-RRB-
cord-001835-0s7ok4uw	4838	1	we	-PRON-	PRP
cord-001835-0s7ok4uw	4838	2	identified	identify	VBD
cord-001835-0s7ok4uw	4838	3	twelve	twelve	CD
cord-001835-0s7ok4uw	4838	4	liver	liver	NN
cord-001835-0s7ok4uw	4838	5	proteins	protein	NNS
cord-001835-0s7ok4uw	4838	6	whose	whose	WP$
cord-001835-0s7ok4uw	4838	7	expression	expression	NN
cord-001835-0s7ok4uw	4838	8	was	be	VBD
cord-001835-0s7ok4uw	4838	9	significantly	significantly	RB
cord-001835-0s7ok4uw	4838	10	altered	alter	VBN
cord-001835-0s7ok4uw	4838	11	as	as	IN
cord-001835-0s7ok4uw	4838	12	a	a	DT
cord-001835-0s7ok4uw	4838	13	result	result	NN
cord-001835-0s7ok4uw	4838	14	of	of	IN
cord-001835-0s7ok4uw	4838	15	the	the	DT
cord-001835-0s7ok4uw	4838	16	Cbs	Cbs	NNP
cord-001835-0s7ok4uw	4838	17	gene	gene	NN
cord-001835-0s7ok4uw	4838	18	inactivation	inactivation	NN
cord-001835-0s7ok4uw	4838	19	.	.	.
cord-001835-0s7ok4uw	4839	1	Expression	expression	NN
cord-001835-0s7ok4uw	4839	2	of	of	IN
cord-001835-0s7ok4uw	4839	3	three	three	CD
cord-001835-0s7ok4uw	4839	4	proteins	protein	NNS
cord-001835-0s7ok4uw	4839	5	was	be	VBD
cord-001835-0s7ok4uw	4839	6	upregulated	upregulate	VBN
cord-001835-0s7ok4uw	4839	7	and	and	CC
cord-001835-0s7ok4uw	4839	8	of	of	IN
cord-001835-0s7ok4uw	4839	9	nine	nine	CD
cord-001835-0s7ok4uw	4839	10	down	down	RB
cord-001835-0s7ok4uw	4839	11	-	-	HYPH
cord-001835-0s7ok4uw	4839	12	regulated	regulate	VBN
cord-001835-0s7ok4uw	4839	13	by	by	IN
cord-001835-0s7ok4uw	4839	14	the	the	DT
cord-001835-0s7ok4uw	4839	15	Cbs-/-genotype	cbs-/-genotype	CD
cord-001835-0s7ok4uw	4839	16	.	.	.
cord-001835-0s7ok4uw	4840	1	Two	two	CD
cord-001835-0s7ok4uw	4840	2	up	up	RB
cord-001835-0s7ok4uw	4840	3	-	-	HYPH
cord-001835-0s7ok4uw	4840	4	regulated	regulate	VBN
cord-001835-0s7ok4uw	4840	5	liver	liver	NN
cord-001835-0s7ok4uw	4840	6	proteins	protein	NNS
cord-001835-0s7ok4uw	4840	7	are	be	VBP
cord-001835-0s7ok4uw	4840	8	involved	involve	VBN
cord-001835-0s7ok4uw	4840	9	in	in	IN
cord-001835-0s7ok4uw	4840	10	iron	iron	NN
cord-001835-0s7ok4uw	4840	11	metabolism	metabolism	NN
cord-001835-0s7ok4uw	4840	12	(	(	-LRB-
cord-001835-0s7ok4uw	4840	13	Ftl	Ftl	NNP
cord-001835-0s7ok4uw	4840	14	and	and	CC
cord-001835-0s7ok4uw	4840	15	Fth	Fth	NNP
cord-001835-0s7ok4uw	4840	16	)	)	-RRB-
cord-001835-0s7ok4uw	4840	17	.	.	.
cord-001835-0s7ok4uw	4841	1	Those	those	DT
cord-001835-0s7ok4uw	4841	2	proteins	protein	NNS
cord-001835-0s7ok4uw	4841	3	are	be	VBP
cord-001835-0s7ok4uw	4841	4	associated	associate	VBN
cord-001835-0s7ok4uw	4841	5	with	with	IN
cord-001835-0s7ok4uw	4841	6	oxidation	oxidation	NN
cord-001835-0s7ok4uw	4841	7	stress	stress	NN
cord-001835-0s7ok4uw	4841	8	and	and	CC
cord-001835-0s7ok4uw	4841	9	inflammation	inflammation	NN
cord-001835-0s7ok4uw	4841	10	.	.	.
cord-001835-0s7ok4uw	4842	1	Third	third	RB
cord-001835-0s7ok4uw	4842	2	up	up	RB
cord-001835-0s7ok4uw	4842	3	-	-	HYPH
cord-001835-0s7ok4uw	4842	4	regulated	regulate	VBN
cord-001835-0s7ok4uw	4842	5	liver	liver	NN
cord-001835-0s7ok4uw	4842	6	protein	protein	NN
cord-001835-0s7ok4uw	4842	7	(	(	-LRB-
cord-001835-0s7ok4uw	4842	8	Cbr3	Cbr3	NNP
cord-001835-0s7ok4uw	4842	9	)	)	-RRB-
cord-001835-0s7ok4uw	4842	10	is	be	VBZ
cord-001835-0s7ok4uw	4842	11	related	relate	VBN
cord-001835-0s7ok4uw	4842	12	to	to	IN
cord-001835-0s7ok4uw	4842	13	oxidation	oxidation	NN
cord-001835-0s7ok4uw	4842	14	-	-	HYPH
cord-001835-0s7ok4uw	4842	15	reduction	reduction	NN
cord-001835-0s7ok4uw	4842	16	process	process	NN
cord-001835-0s7ok4uw	4842	17	.	.	.
cord-001835-0s7ok4uw	4843	1	The	the	DT
cord-001835-0s7ok4uw	4843	2	downregulated	downregulated	JJ
cord-001835-0s7ok4uw	4843	3	protein	protein	NN
cord-001835-0s7ok4uw	4843	4	are	be	VBP
cord-001835-0s7ok4uw	4843	5	involved	involve	VBN
cord-001835-0s7ok4uw	4843	6	in	in	IN
cord-001835-0s7ok4uw	4843	7	the	the	DT
cord-001835-0s7ok4uw	4843	8	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	4843	9	of	of	IN
cord-001835-0s7ok4uw	4843	10	N	n	CD
cord-001835-0s7ok4uw	4843	11	-	-	HYPH
cord-001835-0s7ok4uw	4843	12	acylated	acylate	VBN
cord-001835-0s7ok4uw	4843	13	or	or	CC
cord-001835-0s7ok4uw	4843	14	N	n	CD
cord-001835-0s7ok4uw	4843	15	-	-	HYPH
cord-001835-0s7ok4uw	4843	16	acetylated	acetylated	JJ
cord-001835-0s7ok4uw	4843	17	amino	amino	NN
cord-001835-0s7ok4uw	4843	18	acids	acid	NNS
cord-001835-0s7ok4uw	4843	19	(	(	-LRB-
cord-001835-0s7ok4uw	4843	20	Acy1	Acy1	NNP
cord-001835-0s7ok4uw	4843	21	)	)	-RRB-
cord-001835-0s7ok4uw	4843	22	,	,	,
cord-001835-0s7ok4uw	4843	23	regulation	regulation	NN
cord-001835-0s7ok4uw	4843	24	of	of	IN
cord-001835-0s7ok4uw	4843	25	endopeptidase	endopeptidase	NN
cord-001835-0s7ok4uw	4843	26	activity	activity	NN
cord-001835-0s7ok4uw	4843	27	(	(	-LRB-
cord-001835-0s7ok4uw	4843	28	A1at4	A1at4	NNP
cord-001835-0s7ok4uw	4843	29	)	)	-RRB-
cord-001835-0s7ok4uw	4843	30	,	,	,
cord-001835-0s7ok4uw	4843	31	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	4843	32	biosynthetic	biosynthetic	JJ
cord-001835-0s7ok4uw	4843	33	process	process	NN
cord-001835-0s7ok4uw	4843	34	(	(	-LRB-
cord-001835-0s7ok4uw	4843	35	Fpps	Fpps	NNP
cord-001835-0s7ok4uw	4843	36	)	)	-RRB-
cord-001835-0s7ok4uw	4843	37	,	,	,
cord-001835-0s7ok4uw	4843	38	amino	amino	NN
cord-001835-0s7ok4uw	4843	39	acid	acid	NN
cord-001835-0s7ok4uw	4843	40	degradation	degradation	NN
cord-001835-0s7ok4uw	4843	41	(	(	-LRB-
cord-001835-0s7ok4uw	4843	42	Huth	Huth	NNP
cord-001835-0s7ok4uw	4843	43	)	)	-RRB-
cord-001835-0s7ok4uw	4843	44	,	,	,
cord-001835-0s7ok4uw	4843	45	cellular	cellular	JJ
cord-001835-0s7ok4uw	4843	46	calcium	calcium	NN
cord-001835-0s7ok4uw	4843	47	ion	ion	NN
cord-001835-0s7ok4uw	4843	48	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	4843	49	and	and	CC
cord-001835-0s7ok4uw	4843	50	L	l	NN
cord-001835-0s7ok4uw	4843	51	-	-	HYPH
cord-001835-0s7ok4uw	4843	52	ascorbic	ascorbic	NN
cord-001835-0s7ok4uw	4843	53	acid	acid	NN
cord-001835-0s7ok4uw	4843	54	biosynthetic	biosynthetic	JJ
cord-001835-0s7ok4uw	4843	55	process	process	NN
cord-001835-0s7ok4uw	4843	56	(	(	-LRB-
cord-001835-0s7ok4uw	4843	57	Rgn	Rgn	NNP
cord-001835-0s7ok4uw	4843	58	)	)	-RRB-
cord-001835-0s7ok4uw	4843	59	.	.	.
cord-001835-0s7ok4uw	4844	1	Using	use	VBG
cord-001835-0s7ok4uw	4844	2	label	label	NN
cord-001835-0s7ok4uw	4844	3	-	-	HYPH
cord-001835-0s7ok4uw	4844	4	free	free	JJ
cord-001835-0s7ok4uw	4844	5	based	base	VBN
cord-001835-0s7ok4uw	4844	6	relative	relative	JJ
cord-001835-0s7ok4uw	4844	7	quantitative	quantitative	JJ
cord-001835-0s7ok4uw	4844	8	proteomics	proteomic	NNS
cord-001835-0s7ok4uw	4844	9	(	(	-LRB-
cord-001835-0s7ok4uw	4844	10	n58	n58	NN
cord-001835-0s7ok4uw	4844	11	)	)	-RRB-
cord-001835-0s7ok4uw	4844	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	4844	13	identified	identify	VBD
cord-001835-0s7ok4uw	4844	14	fourteen	fourteen	CD
cord-001835-0s7ok4uw	4844	15	liver	liver	NN
cord-001835-0s7ok4uw	4844	16	proteins	protein	NNS
cord-001835-0s7ok4uw	4844	17	whose	whose	WP$
cord-001835-0s7ok4uw	4844	18	expression	expression	NN
cord-001835-0s7ok4uw	4844	19	was	be	VBD
cord-001835-0s7ok4uw	4844	20	significantly	significantly	RB
cord-001835-0s7ok4uw	4844	21	altered	alter	VBN
cord-001835-0s7ok4uw	4844	22	as	as	IN
cord-001835-0s7ok4uw	4844	23	a	a	DT
cord-001835-0s7ok4uw	4844	24	result	result	NN
cord-001835-0s7ok4uw	4844	25	of	of	IN
cord-001835-0s7ok4uw	4844	26	the	the	DT
cord-001835-0s7ok4uw	4844	27	Cbs	Cbs	NNP
cord-001835-0s7ok4uw	4844	28	gene	gene	NN
cord-001835-0s7ok4uw	4844	29	inactivation	inactivation	NN
cord-001835-0s7ok4uw	4844	30	.	.	.
cord-001835-0s7ok4uw	4845	1	Expression	expression	NN
cord-001835-0s7ok4uw	4845	2	of	of	IN
cord-001835-0s7ok4uw	4845	3	four	four	CD
cord-001835-0s7ok4uw	4845	4	proteins	protein	NNS
cord-001835-0s7ok4uw	4845	5	was	be	VBD
cord-001835-0s7ok4uw	4846	1	up	up	RB
cord-001835-0s7ok4uw	4846	2	-	-	HYPH
cord-001835-0s7ok4uw	4846	3	regulated	regulate	VBN
cord-001835-0s7ok4uw	4846	4	and	and	CC
cord-001835-0s7ok4uw	4846	5	of	of	IN
cord-001835-0s7ok4uw	4846	6	ten	ten	CD
cord-001835-0s7ok4uw	4846	7	proteins	protein	NNS
cord-001835-0s7ok4uw	4846	8	was	be	VBD
cord-001835-0s7ok4uw	4846	9	down	down	RB
cord-001835-0s7ok4uw	4846	10	-	-	HYPH
cord-001835-0s7ok4uw	4846	11	regulated	regulate	VBN
cord-001835-0s7ok4uw	4846	12	.	.	.
cord-001835-0s7ok4uw	4847	1	The	the	DT
cord-001835-0s7ok4uw	4847	2	down	down	RB
cord-001835-0s7ok4uw	4847	3	-	-	HYPH
cord-001835-0s7ok4uw	4847	4	regulated	regulate	VBN
cord-001835-0s7ok4uw	4847	5	liver	liver	NN
cord-001835-0s7ok4uw	4847	6	proteins	protein	NNS
cord-001835-0s7ok4uw	4847	7	are	be	VBP
cord-001835-0s7ok4uw	4847	8	linked	link	VBN
cord-001835-0s7ok4uw	4847	9	with	with	IN
cord-001835-0s7ok4uw	4847	10	regulation	regulation	NN
cord-001835-0s7ok4uw	4847	11	of	of	IN
cord-001835-0s7ok4uw	4847	12	bone	bone	NN
cord-001835-0s7ok4uw	4847	13	mineralization	mineralization	NN
cord-001835-0s7ok4uw	4847	14	and	and	CC
cord-001835-0s7ok4uw	4847	15	inflammatory	inflammatory	JJ
cord-001835-0s7ok4uw	4847	16	response	response	NN
cord-001835-0s7ok4uw	4847	17	(	(	-LRB-
cord-001835-0s7ok4uw	4847	18	Ahsg	Ahsg	NNP
cord-001835-0s7ok4uw	4847	19	)	)	-RRB-
cord-001835-0s7ok4uw	4847	20	or	or	CC
cord-001835-0s7ok4uw	4847	21	regulation	regulation	NN
cord-001835-0s7ok4uw	4847	22	of	of	IN
cord-001835-0s7ok4uw	4847	23	mRNA	mrna	NN
cord-001835-0s7ok4uw	4847	24	splicing	splicing	NN
cord-001835-0s7ok4uw	4847	25	(	(	-LRB-
cord-001835-0s7ok4uw	4847	26	Roa2	Roa2	NNP
cord-001835-0s7ok4uw	4847	27	)	)	-RRB-
cord-001835-0s7ok4uw	4847	28	.	.	.
cord-001835-0s7ok4uw	4848	1	The	the	DT
cord-001835-0s7ok4uw	4848	2	up	up	RB
cord-001835-0s7ok4uw	4848	3	-	-	HYPH
cord-001835-0s7ok4uw	4848	4	regulated	regulate	VBN
cord-001835-0s7ok4uw	4848	5	liver	liver	NN
cord-001835-0s7ok4uw	4848	6	proteins	protein	NNS
cord-001835-0s7ok4uw	4848	7	are	be	VBP
cord-001835-0s7ok4uw	4848	8	involved	involve	VBN
cord-001835-0s7ok4uw	4848	9	in	in	IN
cord-001835-0s7ok4uw	4848	10	tricarboxylic	tricarboxylic	JJ
cord-001835-0s7ok4uw	4848	11	acid	acid	NN
cord-001835-0s7ok4uw	4848	12	cycle	cycle	NN
cord-001835-0s7ok4uw	4848	13	(	(	-LRB-
cord-001835-0s7ok4uw	4848	14	Suca	Suca	NNP
cord-001835-0s7ok4uw	4848	15	)	)	-RRB-
cord-001835-0s7ok4uw	4848	16	,	,	,
cord-001835-0s7ok4uw	4848	17	oxidation	oxidation	NN
cord-001835-0s7ok4uw	4848	18	-	-	HYPH
cord-001835-0s7ok4uw	4848	19	reduction	reduction	NN
cord-001835-0s7ok4uw	4848	20	process	process	NN
cord-001835-0s7ok4uw	4848	21	(	(	-LRB-
cord-001835-0s7ok4uw	4848	22	Cy250	Cy250	NNP
cord-001835-0s7ok4uw	4848	23	)	)	-RRB-
cord-001835-0s7ok4uw	4848	24	,	,	,
cord-001835-0s7ok4uw	4848	25	cholesterol	cholesterol	NN
cord-001835-0s7ok4uw	4848	26	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	4848	27	process	process	NN
cord-001835-0s7ok4uw	4848	28	,	,	,
cord-001835-0s7ok4uw	4848	29	iron	iron	NN
cord-001835-0s7ok4uw	4848	30	ion	ion	NN
cord-001835-0s7ok4uw	4848	31	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	4848	32	(	(	-LRB-
cord-001835-0s7ok4uw	4848	33	Fech	Fech	NNP
cord-001835-0s7ok4uw	4848	34	)	)	-RRB-
cord-001835-0s7ok4uw	4848	35	,	,	,
cord-001835-0s7ok4uw	4848	36	fatty	fatty	JJ
cord-001835-0s7ok4uw	4848	37	acid	acid	NN
cord-001835-0s7ok4uw	4848	38	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	4848	39	process	process	NN
cord-001835-0s7ok4uw	4848	40	(	(	-LRB-
cord-001835-0s7ok4uw	4848	41	Ssdh	Ssdh	NNP
cord-001835-0s7ok4uw	4848	42	;	;	:
cord-001835-0s7ok4uw	4848	43	Eci1	Eci1	NNP
cord-001835-0s7ok4uw	4848	44	)	)	-RRB-
cord-001835-0s7ok4uw	4848	45	and	and	CC
cord-001835-0s7ok4uw	4848	46	response	response	NN
cord-001835-0s7ok4uw	4848	47	to	to	IN
cord-001835-0s7ok4uw	4848	48	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	4848	49	stress	stress	NN
cord-001835-0s7ok4uw	4848	50	(	(	-LRB-
cord-001835-0s7ok4uw	4848	51	Lonm	Lonm	NNP
cord-001835-0s7ok4uw	4848	52	)	)	-RRB-
cord-001835-0s7ok4uw	4848	53	.	.	.
cord-001835-0s7ok4uw	4849	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4849	2	findings	finding	NNS
cord-001835-0s7ok4uw	4849	3	suggests	suggest	VBZ
cord-001835-0s7ok4uw	4849	4	that	that	IN
cord-001835-0s7ok4uw	4849	5	Cbs	Cbs	NNP
cord-001835-0s7ok4uw	4849	6	interacts	interact	VBZ
cord-001835-0s7ok4uw	4849	7	with	with	IN
cord-001835-0s7ok4uw	4849	8	diverse	diverse	JJ
cord-001835-0s7ok4uw	4849	9	cellular	cellular	JJ
cord-001835-0s7ok4uw	4849	10	processes	process	NNS
cord-001835-0s7ok4uw	4849	11	,	,	,
cord-001835-0s7ok4uw	4849	12	including	include	VBG
cord-001835-0s7ok4uw	4849	13	lipid	lipid	NN
cord-001835-0s7ok4uw	4849	14	metabolism	metabolism	NN
cord-001835-0s7ok4uw	4849	15	,	,	,
cord-001835-0s7ok4uw	4849	16	that	that	WDT
cord-001835-0s7ok4uw	4849	17	are	be	VBP
cord-001835-0s7ok4uw	4849	18	essential	essential	JJ
cord-001835-0s7ok4uw	4849	19	for	for	IN
cord-001835-0s7ok4uw	4849	20	normal	normal	JJ
cord-001835-0s7ok4uw	4849	21	liver	liver	NN
cord-001835-0s7ok4uw	4849	22	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	4849	23	.	.	.
cord-001835-0s7ok4uw	4850	1	Deregulation	deregulation	NN
cord-001835-0s7ok4uw	4850	2	of	of	IN
cord-001835-0s7ok4uw	4850	3	genes	gene	NNS
cord-001835-0s7ok4uw	4850	4	involved	involve	VBN
cord-001835-0s7ok4uw	4850	5	in	in	IN
cord-001835-0s7ok4uw	4850	6	lipid	lipid	NN
cord-001835-0s7ok4uw	4850	7	metabolism	metabolism	NN
cord-001835-0s7ok4uw	4850	8	provides	provide	VBZ
cord-001835-0s7ok4uw	4850	9	a	a	DT
cord-001835-0s7ok4uw	4850	10	possible	possible	JJ
cord-001835-0s7ok4uw	4850	11	explanation	explanation	NN
cord-001835-0s7ok4uw	4850	12	for	for	IN
cord-001835-0s7ok4uw	4850	13	fatty	fatty	JJ
cord-001835-0s7ok4uw	4850	14	liver	liver	NN
cord-001835-0s7ok4uw	4850	15	disease	disease	NN
cord-001835-0s7ok4uw	4850	16	associated	associate	VBN
cord-001835-0s7ok4uw	4850	17	with	with	IN
cord-001835-0s7ok4uw	4850	18	CBS	CBS	NNP
cord-001835-0s7ok4uw	4850	19	deficiency	deficiency	NN
cord-001835-0s7ok4uw	4850	20	.	.	.
cord-001835-0s7ok4uw	4851	1	Transcription	transcription	NN
cord-001835-0s7ok4uw	4851	2	factors	factor	NNS
cord-001835-0s7ok4uw	4851	3	play	play	VBP
cord-001835-0s7ok4uw	4851	4	central	central	JJ
cord-001835-0s7ok4uw	4851	5	roles	role	NNS
cord-001835-0s7ok4uw	4851	6	in	in	IN
cord-001835-0s7ok4uw	4851	7	coordinating	coordinate	VBG
cord-001835-0s7ok4uw	4851	8	developmental	developmental	JJ
cord-001835-0s7ok4uw	4851	9	processes	process	NNS
cord-001835-0s7ok4uw	4851	10	,	,	,
cord-001835-0s7ok4uw	4851	11	as	as	IN
cord-001835-0s7ok4uw	4851	12	evidenced	evidence	VBN
cord-001835-0s7ok4uw	4851	13	by	by	IN
cord-001835-0s7ok4uw	4851	14	the	the	DT
cord-001835-0s7ok4uw	4851	15	increasing	increase	VBG
cord-001835-0s7ok4uw	4851	16	number	number	NN
cord-001835-0s7ok4uw	4851	17	of	of	IN
cord-001835-0s7ok4uw	4851	18	transcription	transcription	NN
cord-001835-0s7ok4uw	4851	19	factor	factor	NN
cord-001835-0s7ok4uw	4851	20	-	-	HYPH
cord-001835-0s7ok4uw	4851	21	related	relate	VBN
cord-001835-0s7ok4uw	4851	22	developmental	developmental	JJ
cord-001835-0s7ok4uw	4851	23	disorders	disorder	NNS
cord-001835-0s7ok4uw	4851	24	being	be	VBG
cord-001835-0s7ok4uw	4851	25	uncovered	uncover	VBN
cord-001835-0s7ok4uw	4851	26	by	by	IN
cord-001835-0s7ok4uw	4851	27	nextgeneration	nextgeneration	NN
cord-001835-0s7ok4uw	4851	28	sequencing	sequencing	NN
cord-001835-0s7ok4uw	4851	29	and	and	CC
cord-001835-0s7ok4uw	4851	30	genome	genome	NN
cord-001835-0s7ok4uw	4851	31	-	-	HYPH
cord-001835-0s7ok4uw	4851	32	wide	wide	JJ
cord-001835-0s7ok4uw	4851	33	studies	study	NNS
cord-001835-0s7ok4uw	4851	34	of	of	IN
cord-001835-0s7ok4uw	4851	35	copy	copy	JJ
cord-001835-0s7ok4uw	4851	36	number	number	NN
cord-001835-0s7ok4uw	4851	37	variation	variation	NN
cord-001835-0s7ok4uw	4851	38	.	.	.
cord-001835-0s7ok4uw	4852	1	The	the	DT
cord-001835-0s7ok4uw	4852	2	action	action	NN
cord-001835-0s7ok4uw	4852	3	of	of	IN
cord-001835-0s7ok4uw	4852	4	a	a	DT
cord-001835-0s7ok4uw	4852	5	transcription	transcription	NN
cord-001835-0s7ok4uw	4852	6	factor	factor	NN
cord-001835-0s7ok4uw	4852	7	in	in	IN
cord-001835-0s7ok4uw	4852	8	regulating	regulate	VBG
cord-001835-0s7ok4uw	4852	9	gene	gene	NN
cord-001835-0s7ok4uw	4852	10	expression	expression	NN
cord-001835-0s7ok4uw	4852	11	depends	depend	VBZ
cord-001835-0s7ok4uw	4852	12	on	on	IN
cord-001835-0s7ok4uw	4852	13	interactions	interaction	NNS
cord-001835-0s7ok4uw	4852	14	with	with	IN
cord-001835-0s7ok4uw	4852	15	other	other	JJ
cord-001835-0s7ok4uw	4852	16	transcription	transcription	NN
cord-001835-0s7ok4uw	4852	17	factors	factor	NNS
cord-001835-0s7ok4uw	4852	18	,	,	,
cord-001835-0s7ok4uw	4852	19	coactivators	coactivators	NNP
cord-001835-0s7ok4uw	4852	20	/	/	SYM
cord-001835-0s7ok4uw	4852	21	co	co	NNS
cord-001835-0s7ok4uw	4852	22	-	-	NNS
cord-001835-0s7ok4uw	4852	23	repressors	repressor	NNS
cord-001835-0s7ok4uw	4852	24	and	and	CC
cord-001835-0s7ok4uw	4852	25	chromatin	chromatin	NN
cord-001835-0s7ok4uw	4852	26	modifying	modify	VBG
cord-001835-0s7ok4uw	4852	27	and	and	CC
cord-001835-0s7ok4uw	4852	28	remodeling	remodeling	NN
cord-001835-0s7ok4uw	4852	29	complexes	complex	NNS
cord-001835-0s7ok4uw	4852	30	.	.	.
cord-001835-0s7ok4uw	4853	1	Transcription	transcription	NN
cord-001835-0s7ok4uw	4853	2	factors	factor	NNS
cord-001835-0s7ok4uw	4853	3	are	be	VBP
cord-001835-0s7ok4uw	4853	4	commonly	commonly	RB
cord-001835-0s7ok4uw	4853	5	regulated	regulate	VBN
cord-001835-0s7ok4uw	4853	6	by	by	IN
cord-001835-0s7ok4uw	4853	7	post	post	JJ
cord-001835-0s7ok4uw	4853	8	-	-	JJ
cord-001835-0s7ok4uw	4853	9	translational	translational	JJ
cord-001835-0s7ok4uw	4853	10	modifications	modification	NNS
cord-001835-0s7ok4uw	4853	11	.	.	.
cord-001835-0s7ok4uw	4854	1	However	however	RB
cord-001835-0s7ok4uw	4854	2	the	the	DT
cord-001835-0s7ok4uw	4854	3	study	study	NN
cord-001835-0s7ok4uw	4854	4	of	of	IN
cord-001835-0s7ok4uw	4854	5	protein	protein	NN
cord-001835-0s7ok4uw	4854	6	-	-	HYPH
cord-001835-0s7ok4uw	4854	7	protein	protein	NN
cord-001835-0s7ok4uw	4854	8	interactions	interaction	NNS
cord-001835-0s7ok4uw	4854	9	and	and	CC
cord-001835-0s7ok4uw	4854	10	post	post	JJ
cord-001835-0s7ok4uw	4854	11	-	-	JJ
cord-001835-0s7ok4uw	4854	12	translational	translational	JJ
cord-001835-0s7ok4uw	4854	13	modifications	modification	NNS
cord-001835-0s7ok4uw	4854	14	of	of	IN
cord-001835-0s7ok4uw	4854	15	transcription	transcription	NN
cord-001835-0s7ok4uw	4854	16	factors	factor	NNS
cord-001835-0s7ok4uw	4854	17	by	by	IN
cord-001835-0s7ok4uw	4854	18	common	common	JJ
cord-001835-0s7ok4uw	4854	19	techniques	technique	NNS
cord-001835-0s7ok4uw	4854	20	such	such	JJ
cord-001835-0s7ok4uw	4854	21	as	as	IN
cord-001835-0s7ok4uw	4854	22	coimmunoprecipitation	coimmunoprecipitation	NN
cord-001835-0s7ok4uw	4854	23	and	and	CC
cord-001835-0s7ok4uw	4854	24	mass	mass	NN
cord-001835-0s7ok4uw	4854	25	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4854	26	is	be	VBZ
cord-001835-0s7ok4uw	4854	27	hampered	hamper	VBN
cord-001835-0s7ok4uw	4854	28	by	by	IN
cord-001835-0s7ok4uw	4854	29	the	the	DT
cord-001835-0s7ok4uw	4854	30	difficulty	difficulty	NN
cord-001835-0s7ok4uw	4854	31	in	in	IN
cord-001835-0s7ok4uw	4854	32	preserving	preserve	VBG
cord-001835-0s7ok4uw	4854	33	interactions	interaction	NNS
cord-001835-0s7ok4uw	4854	34	and	and	CC
cord-001835-0s7ok4uw	4854	35	modifications	modification	NNS
cord-001835-0s7ok4uw	4854	36	through	through	IN
cord-001835-0s7ok4uw	4854	37	cell	cell	NN
cord-001835-0s7ok4uw	4854	38	lysis	lysis	NN
cord-001835-0s7ok4uw	4854	39	.	.	.
cord-001835-0s7ok4uw	4855	1	To	to	TO
cord-001835-0s7ok4uw	4855	2	circumvent	circumvent	VB
cord-001835-0s7ok4uw	4855	3	this	this	DT
cord-001835-0s7ok4uw	4855	4	issue	issue	NN
cord-001835-0s7ok4uw	4855	5	,	,	,
cord-001835-0s7ok4uw	4855	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	4855	7	developed	develop	VBD
cord-001835-0s7ok4uw	4855	8	a	a	DT
cord-001835-0s7ok4uw	4855	9	Bioluminescence	Bioluminescence	NNP
cord-001835-0s7ok4uw	4855	10	Resonance	Resonance	NNP
cord-001835-0s7ok4uw	4855	11	Energy	Energy	NNP
cord-001835-0s7ok4uw	4855	12	Transfer	Transfer	NNP
cord-001835-0s7ok4uw	4855	13	(	(	-LRB-
cord-001835-0s7ok4uw	4855	14	BRET	BRET	NNP
cord-001835-0s7ok4uw	4855	15	)	)	-RRB-
cord-001835-0s7ok4uw	4855	16	assay	assay	NN
cord-001835-0s7ok4uw	4855	17	,	,	,
cord-001835-0s7ok4uw	4855	18	which	which	WDT
cord-001835-0s7ok4uw	4855	19	allows	allow	VBZ
cord-001835-0s7ok4uw	4855	20	protein	protein	NN
cord-001835-0s7ok4uw	4855	21	-	-	HYPH
cord-001835-0s7ok4uw	4855	22	protein	protein	NN
cord-001835-0s7ok4uw	4855	23	interactions	interaction	NNS
cord-001835-0s7ok4uw	4855	24	to	to	TO
cord-001835-0s7ok4uw	4855	25	be	be	VB
cord-001835-0s7ok4uw	4855	26	observed	observe	VBN
cord-001835-0s7ok4uw	4855	27	in	in	IN
cord-001835-0s7ok4uw	4855	28	live	live	JJ
cord-001835-0s7ok4uw	4855	29	cells	cell	NNS
cord-001835-0s7ok4uw	4855	30	.	.	.
cord-001835-0s7ok4uw	4856	1	In	in	IN
cord-001835-0s7ok4uw	4856	2	this	this	DT
cord-001835-0s7ok4uw	4856	3	assay	assay	NN
cord-001835-0s7ok4uw	4856	4	,	,	,
cord-001835-0s7ok4uw	4856	5	a	a	DT
cord-001835-0s7ok4uw	4856	6	protein	protein	NN
cord-001835-0s7ok4uw	4856	7	of	of	IN
cord-001835-0s7ok4uw	4856	8	interest	interest	NN
cord-001835-0s7ok4uw	4856	9	is	be	VBZ
cord-001835-0s7ok4uw	4856	10	expressed	express	VBN
cord-001835-0s7ok4uw	4856	11	as	as	IN
cord-001835-0s7ok4uw	4856	12	a	a	DT
cord-001835-0s7ok4uw	4856	13	fusion	fusion	NN
cord-001835-0s7ok4uw	4856	14	with	with	IN
cord-001835-0s7ok4uw	4856	15	luciferase	luciferase	NN
cord-001835-0s7ok4uw	4856	16	from	from	IN
cord-001835-0s7ok4uw	4856	17	Renilla	Renilla	NNP
cord-001835-0s7ok4uw	4856	18	reniformis	reniformis	NNP
cord-001835-0s7ok4uw	4856	19	,	,	,
cord-001835-0s7ok4uw	4856	20	and	and	CC
cord-001835-0s7ok4uw	4856	21	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4856	22	putative	putative	JJ
cord-001835-0s7ok4uw	4856	23	interaction	interaction	NN
cord-001835-0s7ok4uw	4856	24	partner	partner	NN
cord-001835-0s7ok4uw	4856	25	as	as	IN
cord-001835-0s7ok4uw	4856	26	a	a	DT
cord-001835-0s7ok4uw	4856	27	fusion	fusion	NN
cord-001835-0s7ok4uw	4856	28	with	with	IN
cord-001835-0s7ok4uw	4856	29	Yellow	Yellow	NNP
cord-001835-0s7ok4uw	4856	30	Fluorescent	Fluorescent	NNP
cord-001835-0s7ok4uw	4856	31	Protein	Protein	NNP
cord-001835-0s7ok4uw	4856	32	(	(	-LRB-
cord-001835-0s7ok4uw	4856	33	YFP	YFP	NNP
cord-001835-0s7ok4uw	4856	34	)	)	-RRB-
cord-001835-0s7ok4uw	4856	35	.	.	.
cord-001835-0s7ok4uw	4857	1	Upon	upon	IN
cord-001835-0s7ok4uw	4857	2	addition	addition	NN
cord-001835-0s7ok4uw	4857	3	of	of	IN
cord-001835-0s7ok4uw	4857	4	a	a	DT
cord-001835-0s7ok4uw	4857	5	cell	cell	NN
cord-001835-0s7ok4uw	4857	6	-	-	HYPH
cord-001835-0s7ok4uw	4857	7	permeable	permeable	JJ
cord-001835-0s7ok4uw	4857	8	substrate	substrate	NN
cord-001835-0s7ok4uw	4857	9	,	,	,
cord-001835-0s7ok4uw	4857	10	the	the	DT
cord-001835-0s7ok4uw	4857	11	distance	distance	NN
cord-001835-0s7ok4uw	4857	12	-	-	HYPH
cord-001835-0s7ok4uw	4857	13	dependent	dependent	JJ
cord-001835-0s7ok4uw	4857	14	non	non	JJ
cord-001835-0s7ok4uw	4857	15	-	-	JJ
cord-001835-0s7ok4uw	4857	16	radiative	radiative	JJ
cord-001835-0s7ok4uw	4857	17	transfer	transfer	NN
cord-001835-0s7ok4uw	4857	18	of	of	IN
cord-001835-0s7ok4uw	4857	19	energy	energy	NN
cord-001835-0s7ok4uw	4857	20	from	from	IN
cord-001835-0s7ok4uw	4857	21	luciferase	luciferase	NN
cord-001835-0s7ok4uw	4857	22	to	to	IN
cord-001835-0s7ok4uw	4857	23	YFP	YFP	NNP
cord-001835-0s7ok4uw	4857	24	is	be	VBZ
cord-001835-0s7ok4uw	4857	25	quantified	quantify	VBN
cord-001835-0s7ok4uw	4857	26	by	by	IN
cord-001835-0s7ok4uw	4857	27	measurement	measurement	NN
cord-001835-0s7ok4uw	4857	28	of	of	IN
cord-001835-0s7ok4uw	4857	29	light	light	JJ
cord-001835-0s7ok4uw	4857	30	emission	emission	NN
cord-001835-0s7ok4uw	4857	31	at	at	IN
cord-001835-0s7ok4uw	4857	32	two	two	CD
cord-001835-0s7ok4uw	4857	33	wavelengths	wavelength	NNS
cord-001835-0s7ok4uw	4857	34	to	to	TO
cord-001835-0s7ok4uw	4857	35	assess	assess	VB
cord-001835-0s7ok4uw	4857	36	the	the	DT
cord-001835-0s7ok4uw	4857	37	interaction	interaction	NN
cord-001835-0s7ok4uw	4857	38	between	between	IN
cord-001835-0s7ok4uw	4857	39	the	the	DT
cord-001835-0s7ok4uw	4857	40	two	two	CD
cord-001835-0s7ok4uw	4857	41	fusion	fusion	NN
cord-001835-0s7ok4uw	4857	42	proteins	protein	NNS
cord-001835-0s7ok4uw	4857	43	.	.	.
cord-001835-0s7ok4uw	4858	1	To	to	TO
cord-001835-0s7ok4uw	4858	2	validate	validate	VB
cord-001835-0s7ok4uw	4858	3	the	the	DT
cord-001835-0s7ok4uw	4858	4	utility	utility	NN
cord-001835-0s7ok4uw	4858	5	of	of	IN
cord-001835-0s7ok4uw	4858	6	this	this	DT
cord-001835-0s7ok4uw	4858	7	assay	assay	NN
cord-001835-0s7ok4uw	4858	8	for	for	IN
cord-001835-0s7ok4uw	4858	9	investigating	investigate	VBG
cord-001835-0s7ok4uw	4858	10	transcription	transcription	NN
cord-001835-0s7ok4uw	4858	11	factor	factor	NN
cord-001835-0s7ok4uw	4858	12	interactions	interaction	NNS
cord-001835-0s7ok4uw	4858	13	,	,	,
cord-001835-0s7ok4uw	4858	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	4858	15	confirmed	confirm	VBD
cord-001835-0s7ok4uw	4858	16	homodimerization	homodimerization	NN
cord-001835-0s7ok4uw	4858	17	of	of	IN
cord-001835-0s7ok4uw	4858	18	the	the	DT
cord-001835-0s7ok4uw	4858	19	FOXP2	foxp2	NN
cord-001835-0s7ok4uw	4858	20	transcription	transcription	NN
cord-001835-0s7ok4uw	4858	21	factor	factor	NN
cord-001835-0s7ok4uw	4858	22	,	,	,
cord-001835-0s7ok4uw	4858	23	haploinsufficiency	haploinsufficiency	NN
cord-001835-0s7ok4uw	4858	24	of	of	IN
cord-001835-0s7ok4uw	4858	25	which	which	WDT
cord-001835-0s7ok4uw	4858	26	causes	cause	VBZ
cord-001835-0s7ok4uw	4858	27	a	a	DT
cord-001835-0s7ok4uw	4858	28	rare	rare	JJ
cord-001835-0s7ok4uw	4858	29	and	and	CC
cord-001835-0s7ok4uw	4858	30	severe	severe	JJ
cord-001835-0s7ok4uw	4858	31	speech	speech	NN
cord-001835-0s7ok4uw	4858	32	and	and	CC
cord-001835-0s7ok4uw	4858	33	language	language	NN
cord-001835-0s7ok4uw	4858	34	disorder	disorder	NN
cord-001835-0s7ok4uw	4858	35	,	,	,
cord-001835-0s7ok4uw	4858	36	as	as	RB
cord-001835-0s7ok4uw	4858	37	well	well	RB
cord-001835-0s7ok4uw	4858	38	as	as	IN
cord-001835-0s7ok4uw	4858	39	interaction	interaction	NN
cord-001835-0s7ok4uw	4858	40	of	of	IN
cord-001835-0s7ok4uw	4858	41	FOXP2	foxp2	NN
cord-001835-0s7ok4uw	4858	42	with	with	IN
cord-001835-0s7ok4uw	4858	43	other	other	JJ
cord-001835-0s7ok4uw	4858	44	members	member	NNS
cord-001835-0s7ok4uw	4858	45	of	of	IN
cord-001835-0s7ok4uw	4858	46	the	the	DT
cord-001835-0s7ok4uw	4858	47	FOXP	FOXP	NNP
cord-001835-0s7ok4uw	4858	48	family	family	NN
cord-001835-0s7ok4uw	4858	49	.	.	.
cord-001835-0s7ok4uw	4859	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4859	2	also	also	RB
cord-001835-0s7ok4uw	4859	3	confirmed	confirm	VBD
cord-001835-0s7ok4uw	4859	4	the	the	DT
cord-001835-0s7ok4uw	4859	5	interaction	interaction	NN
cord-001835-0s7ok4uw	4859	6	between	between	IN
cord-001835-0s7ok4uw	4859	7	FOXP2	foxp2	NN
cord-001835-0s7ok4uw	4859	8	and	and	CC
cord-001835-0s7ok4uw	4859	9	multiple	multiple	JJ
cord-001835-0s7ok4uw	4859	10	candidate	candidate	NN
cord-001835-0s7ok4uw	4859	11	interactors	interactor	NNS
cord-001835-0s7ok4uw	4859	12	identified	identify	VBN
cord-001835-0s7ok4uw	4859	13	through	through	IN
cord-001835-0s7ok4uw	4859	14	yeast	yeast	NN
cord-001835-0s7ok4uw	4859	15	two	two	CD
cord-001835-0s7ok4uw	4859	16	-	-	HYPH
cord-001835-0s7ok4uw	4859	17	hybrid	hybrid	NN
cord-001835-0s7ok4uw	4859	18	assays	assay	NNS
cord-001835-0s7ok4uw	4859	19	,	,	,
cord-001835-0s7ok4uw	4859	20	including	include	VBG
cord-001835-0s7ok4uw	4859	21	the	the	DT
cord-001835-0s7ok4uw	4859	22	autism	autism	NN
cord-001835-0s7ok4uw	4859	23	-	-	HYPH
cord-001835-0s7ok4uw	4859	24	related	relate	VBN
cord-001835-0s7ok4uw	4859	25	transcription	transcription	NN
cord-001835-0s7ok4uw	4859	26	factor	factor	NN
cord-001835-0s7ok4uw	4859	27	TBR1	TBR1	NNP
cord-001835-0s7ok4uw	4859	28	,	,	,
cord-001835-0s7ok4uw	4859	29	the	the	DT
cord-001835-0s7ok4uw	4859	30	co	co	NNS
cord-001835-0s7ok4uw	4859	31	-	-	NN
cord-001835-0s7ok4uw	4859	32	repressors	repressors	JJ
cord-001835-0s7ok4uw	4859	33	CtBP1	CtBP1	NNP
cord-001835-0s7ok4uw	4859	34	and	and	CC
cord-001835-0s7ok4uw	4859	35	CtBP2	CtBP2	NNP
cord-001835-0s7ok4uw	4859	36	,	,	,
cord-001835-0s7ok4uw	4859	37	and	and	CC
cord-001835-0s7ok4uw	4859	38	post	post	JJ
cord-001835-0s7ok4uw	4859	39	-	-	JJ
cord-001835-0s7ok4uw	4859	40	translational	translational	JJ
cord-001835-0s7ok4uw	4859	41	modification	modification	NN
cord-001835-0s7ok4uw	4859	42	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4859	43	of	of	IN
cord-001835-0s7ok4uw	4859	44	the	the	DT
cord-001835-0s7ok4uw	4859	45	PIAS	PIAS	NNP
cord-001835-0s7ok4uw	4859	46	family	family	NN
cord-001835-0s7ok4uw	4859	47	.	.	.
cord-001835-0s7ok4uw	4860	1	The	the	DT
cord-001835-0s7ok4uw	4860	2	role	role	NN
cord-001835-0s7ok4uw	4860	3	of	of	IN
cord-001835-0s7ok4uw	4860	4	PIAS	PIAS	NNP
cord-001835-0s7ok4uw	4860	5	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4860	6	in	in	IN
cord-001835-0s7ok4uw	4860	7	sumoylation	sumoylation	NN
cord-001835-0s7ok4uw	4860	8	-the	-the	ADD
cord-001835-0s7ok4uw	4860	9	covalent	covalent	JJ
cord-001835-0s7ok4uw	4860	10	modification	modification	NN
cord-001835-0s7ok4uw	4860	11	of	of	IN
cord-001835-0s7ok4uw	4860	12	proteins	protein	NNS
cord-001835-0s7ok4uw	4860	13	with	with	IN
cord-001835-0s7ok4uw	4860	14	Small	Small	NNP
cord-001835-0s7ok4uw	4860	15	Ubiquitin	Ubiquitin	NNP
cord-001835-0s7ok4uw	4860	16	-	-	HYPH
cord-001835-0s7ok4uw	4860	17	like	like	JJ
cord-001835-0s7ok4uw	4860	18	Modifier	modifier	NN
cord-001835-0s7ok4uw	4860	19	(	(	-LRB-
cord-001835-0s7ok4uw	4860	20	SUMO	SUMO	NNP
cord-001835-0s7ok4uw	4860	21	)	)	-RRB-
cord-001835-0s7ok4uw	4860	22	proteins	protein	NNS
cord-001835-0s7ok4uw	4860	23	-led	-le	VBD
cord-001835-0s7ok4uw	4860	24	us	-PRON-	PRP
cord-001835-0s7ok4uw	4860	25	to	to	TO
cord-001835-0s7ok4uw	4860	26	further	further	RB
cord-001835-0s7ok4uw	4860	27	explore	explore	VB
cord-001835-0s7ok4uw	4860	28	this	this	DT
cord-001835-0s7ok4uw	4860	29	process	process	NN
cord-001835-0s7ok4uw	4860	30	,	,	,
cord-001835-0s7ok4uw	4860	31	which	which	WDT
cord-001835-0s7ok4uw	4860	32	is	be	VBZ
cord-001835-0s7ok4uw	4860	33	notably	notably	RB
cord-001835-0s7ok4uw	4860	34	difficult	difficult	JJ
cord-001835-0s7ok4uw	4860	35	to	to	TO
cord-001835-0s7ok4uw	4860	36	investigate	investigate	VB
cord-001835-0s7ok4uw	4860	37	because	because	IN
cord-001835-0s7ok4uw	4860	38	of	of	IN
cord-001835-0s7ok4uw	4860	39	the	the	DT
cord-001835-0s7ok4uw	4860	40	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	4860	41	and	and	CC
cord-001835-0s7ok4uw	4860	42	labile	labile	JJ
cord-001835-0s7ok4uw	4860	43	nature	nature	NN
cord-001835-0s7ok4uw	4860	44	of	of	IN
cord-001835-0s7ok4uw	4860	45	the	the	DT
cord-001835-0s7ok4uw	4860	46	modification	modification	NN
cord-001835-0s7ok4uw	4860	47	,	,	,
cord-001835-0s7ok4uw	4860	48	which	which	WDT
cord-001835-0s7ok4uw	4860	49	is	be	VBZ
cord-001835-0s7ok4uw	4860	50	also	also	RB
cord-001835-0s7ok4uw	4860	51	typically	typically	RB
cord-001835-0s7ok4uw	4860	52	present	present	JJ
cord-001835-0s7ok4uw	4860	53	on	on	IN
cord-001835-0s7ok4uw	4860	54	only	only	RB
cord-001835-0s7ok4uw	4860	55	a	a	DT
cord-001835-0s7ok4uw	4860	56	minor	minor	JJ
cord-001835-0s7ok4uw	4860	57	fraction	fraction	NN
cord-001835-0s7ok4uw	4860	58	of	of	IN
cord-001835-0s7ok4uw	4860	59	molecules	molecule	NNS
cord-001835-0s7ok4uw	4860	60	of	of	IN
cord-001835-0s7ok4uw	4860	61	a	a	DT
cord-001835-0s7ok4uw	4860	62	given	give	VBN
cord-001835-0s7ok4uw	4860	63	protein	protein	NN
cord-001835-0s7ok4uw	4860	64	.	.	.
cord-001835-0s7ok4uw	4861	1	Combining	combine	VBG
cord-001835-0s7ok4uw	4861	2	the	the	DT
cord-001835-0s7ok4uw	4861	3	BRET	BRET	NNP
cord-001835-0s7ok4uw	4861	4	assay	assay	NN
cord-001835-0s7ok4uw	4861	5	with	with	IN
cord-001835-0s7ok4uw	4861	6	gel	gel	NN
cord-001835-0s7ok4uw	4861	7	-	-	HYPH
cord-001835-0s7ok4uw	4861	8	shift	shift	NN
cord-001835-0s7ok4uw	4861	9	techniques	technique	NNS
cord-001835-0s7ok4uw	4861	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	4861	11	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	4861	12	that	that	IN
cord-001835-0s7ok4uw	4861	13	FOXP2	FOXP2	NNP
cord-001835-0s7ok4uw	4861	14	is	be	VBZ
cord-001835-0s7ok4uw	4861	15	sumoylated	sumoylate	VBN
cord-001835-0s7ok4uw	4861	16	.	.	.
cord-001835-0s7ok4uw	4862	1	Finally	finally	RB
cord-001835-0s7ok4uw	4862	2	,	,	,
cord-001835-0s7ok4uw	4862	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4862	4	used	use	VBD
cord-001835-0s7ok4uw	4862	5	the	the	DT
cord-001835-0s7ok4uw	4862	6	BRET	BRET	NNP
cord-001835-0s7ok4uw	4862	7	assay	assay	NN
cord-001835-0s7ok4uw	4862	8	to	to	TO
cord-001835-0s7ok4uw	4862	9	examine	examine	VB
cord-001835-0s7ok4uw	4862	10	the	the	DT
cord-001835-0s7ok4uw	4862	11	effects	effect	NNS
cord-001835-0s7ok4uw	4862	12	of	of	IN
cord-001835-0s7ok4uw	4862	13	etiological	etiological	JJ
cord-001835-0s7ok4uw	4862	14	FOXP2	foxp2	NN
cord-001835-0s7ok4uw	4862	15	variants	variant	NNS
cord-001835-0s7ok4uw	4862	16	in	in	IN
cord-001835-0s7ok4uw	4862	17	speech	speech	NN
cord-001835-0s7ok4uw	4862	18	and	and	CC
cord-001835-0s7ok4uw	4862	19	language	language	NN
cord-001835-0s7ok4uw	4862	20	disorder	disorder	NN
cord-001835-0s7ok4uw	4862	21	on	on	IN
cord-001835-0s7ok4uw	4862	22	protein	protein	NN
cord-001835-0s7ok4uw	4862	23	-	-	HYPH
cord-001835-0s7ok4uw	4862	24	protein	protein	NN
cord-001835-0s7ok4uw	4862	25	interactions	interaction	NNS
cord-001835-0s7ok4uw	4862	26	and	and	CC
cord-001835-0s7ok4uw	4862	27	post	post	JJ
cord-001835-0s7ok4uw	4862	28	-	-	JJ
cord-001835-0s7ok4uw	4862	29	translational	translational	JJ
cord-001835-0s7ok4uw	4862	30	modification	modification	NN
cord-001835-0s7ok4uw	4862	31	.	.	.
cord-001835-0s7ok4uw	4863	1	In	in	IN
cord-001835-0s7ok4uw	4863	2	summary	summary	NN
cord-001835-0s7ok4uw	4863	3	,	,	,
cord-001835-0s7ok4uw	4863	4	the	the	DT
cord-001835-0s7ok4uw	4863	5	BRET	BRET	NNP
cord-001835-0s7ok4uw	4863	6	assay	assay	NN
cord-001835-0s7ok4uw	4863	7	is	be	VBZ
cord-001835-0s7ok4uw	4863	8	a	a	DT
cord-001835-0s7ok4uw	4863	9	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	4863	10	,	,	,
cord-001835-0s7ok4uw	4863	11	reliable	reliable	JJ
cord-001835-0s7ok4uw	4863	12	and	and	CC
cord-001835-0s7ok4uw	4863	13	potentially	potentially	RB
cord-001835-0s7ok4uw	4863	14	high	high	JJ
cord-001835-0s7ok4uw	4863	15	-	-	HYPH
cord-001835-0s7ok4uw	4863	16	throughput	throughput	NN
cord-001835-0s7ok4uw	4863	17	technique	technique	NN
cord-001835-0s7ok4uw	4863	18	for	for	IN
cord-001835-0s7ok4uw	4863	19	exploring	explore	VBG
cord-001835-0s7ok4uw	4863	20	protein	protein	NN
cord-001835-0s7ok4uw	4863	21	biology	biology	NN
cord-001835-0s7ok4uw	4863	22	in	in	IN
cord-001835-0s7ok4uw	4863	23	the	the	DT
cord-001835-0s7ok4uw	4863	24	context	context	NN
cord-001835-0s7ok4uw	4863	25	of	of	IN
cord-001835-0s7ok4uw	4863	26	live	live	JJ
cord-001835-0s7ok4uw	4863	27	cells	cell	NNS
cord-001835-0s7ok4uw	4863	28	.	.	.
cord-001835-0s7ok4uw	4864	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4864	2	have	have	VBP
cord-001835-0s7ok4uw	4864	3	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	4864	4	applications	application	NNS
cord-001835-0s7ok4uw	4864	5	of	of	IN
cord-001835-0s7ok4uw	4864	6	the	the	DT
cord-001835-0s7ok4uw	4864	7	assay	assay	NN
cord-001835-0s7ok4uw	4864	8	in	in	IN
cord-001835-0s7ok4uw	4864	9	validating	validate	VBG
cord-001835-0s7ok4uw	4864	10	putative	putative	JJ
cord-001835-0s7ok4uw	4864	11	protein	protein	NN
cord-001835-0s7ok4uw	4864	12	-	-	HYPH
cord-001835-0s7ok4uw	4864	13	protein	protein	NN
cord-001835-0s7ok4uw	4864	14	interactions	interaction	NNS
cord-001835-0s7ok4uw	4864	15	,	,	,
cord-001835-0s7ok4uw	4864	16	assessing	assess	VBG
cord-001835-0s7ok4uw	4864	17	posttranslational	posttranslational	JJ
cord-001835-0s7ok4uw	4864	18	modifications	modification	NNS
cord-001835-0s7ok4uw	4864	19	,	,	,
cord-001835-0s7ok4uw	4864	20	and	and	CC
cord-001835-0s7ok4uw	4864	21	investigating	investigate	VBG
cord-001835-0s7ok4uw	4864	22	functional	functional	JJ
cord-001835-0s7ok4uw	4864	23	effects	effect	NNS
cord-001835-0s7ok4uw	4864	24	of	of	IN
cord-001835-0s7ok4uw	4864	25	protein	protein	NN
cord-001835-0s7ok4uw	4864	26	variants	variant	NNS
cord-001835-0s7ok4uw	4864	27	identified	identify	VBN
cord-001835-0s7ok4uw	4864	28	in	in	IN
cord-001835-0s7ok4uw	4864	29	patient	patient	JJ
cord-001835-0s7ok4uw	4864	30	cohorts	cohort	NNS
cord-001835-0s7ok4uw	4864	31	.	.	.
cord-001835-0s7ok4uw	4865	1	These	these	DT
cord-001835-0s7ok4uw	4865	2	investigations	investigation	NNS
cord-001835-0s7ok4uw	4865	3	have	have	VBP
cord-001835-0s7ok4uw	4865	4	provided	provide	VBN
cord-001835-0s7ok4uw	4865	5	novel	novel	JJ
cord-001835-0s7ok4uw	4865	6	insights	insight	NNS
cord-001835-0s7ok4uw	4865	7	into	into	IN
cord-001835-0s7ok4uw	4865	8	the	the	DT
cord-001835-0s7ok4uw	4865	9	function	function	NN
cord-001835-0s7ok4uw	4865	10	of	of	IN
cord-001835-0s7ok4uw	4865	11	the	the	DT
cord-001835-0s7ok4uw	4865	12	FOXP2	foxp2	NN
cord-001835-0s7ok4uw	4865	13	transcription	transcription	NN
cord-001835-0s7ok4uw	4865	14	factor	factor	NN
cord-001835-0s7ok4uw	4865	15	in	in	IN
cord-001835-0s7ok4uw	4865	16	neurodevelopment	neurodevelopment	NN
cord-001835-0s7ok4uw	4865	17	and	and	CC
cord-001835-0s7ok4uw	4865	18	into	into	IN
cord-001835-0s7ok4uw	4865	19	the	the	DT
cord-001835-0s7ok4uw	4865	20	etiology	etiology	NN
cord-001835-0s7ok4uw	4865	21	of	of	IN
cord-001835-0s7ok4uw	4865	22	FOXP2-related	FOXP2-related	NNP
cord-001835-0s7ok4uw	4865	23	speech	speech	NN
cord-001835-0s7ok4uw	4865	24	and	and	CC
cord-001835-0s7ok4uw	4865	25	language	language	NN
cord-001835-0s7ok4uw	4865	26	disorder	disorder	NN
cord-001835-0s7ok4uw	4865	27	.	.	.
cord-001835-0s7ok4uw	4866	1	The	the	DT
cord-001835-0s7ok4uw	4866	2	directly	directly	JJ
cord-001835-0s7ok4uw	4866	3	interaction	interaction	NN
cord-001835-0s7ok4uw	4866	4	between	between	IN
cord-001835-0s7ok4uw	4866	5	PreS1	PreS1	NNP
cord-001835-0s7ok4uw	4866	6	of	of	IN
cord-001835-0s7ok4uw	4866	7	human	human	JJ
cord-001835-0s7ok4uw	4866	8	virus	virus	NN
cord-001835-0s7ok4uw	4866	9	B	b	NN
cord-001835-0s7ok4uw	4866	10	and	and	CC
cord-001835-0s7ok4uw	4866	11	human	human	JJ
cord-001835-0s7ok4uw	4866	12	heat	heat	NN
cord-001835-0s7ok4uw	4866	13	shock	shock	NN
cord-001835-0s7ok4uw	4866	14	protein	protein	NN
cord-001835-0s7ok4uw	4866	15	70	70	CD
cord-001835-0s7ok4uw	4866	16	(	(	-LRB-
cord-001835-0s7ok4uw	4866	17	HSP70	HSP70	NNP
cord-001835-0s7ok4uw	4866	18	)	)	-RRB-
cord-001835-0s7ok4uw	4867	1	Deqiang	Deqiang	NNP
cord-001835-0s7ok4uw	4867	2	Wang	Wang	NNP
cord-001835-0s7ok4uw	4867	3	1	1	CD
cord-001835-0s7ok4uw	4867	4	,	,	,
cord-001835-0s7ok4uw	4867	5	Chen	Chen	NNP
cord-001835-0s7ok4uw	4867	6	Ke	Ke	NNP
cord-001835-0s7ok4uw	4867	7	1	1	CD
cord-001835-0s7ok4uw	4867	8	,	,	,
cord-001835-0s7ok4uw	4867	9	Jun	Jun	NNP
cord-001835-0s7ok4uw	4867	10	Zhang	Zhang	NNP
cord-001835-0s7ok4uw	4868	1	2	2	LS
cord-001835-0s7ok4uw	4868	2	1	1	CD
cord-001835-0s7ok4uw	4868	3	Key	Key	NNP
cord-001835-0s7ok4uw	4868	4	Laboratory	Laboratory	NNP
cord-001835-0s7ok4uw	4868	5	of	of	IN
cord-001835-0s7ok4uw	4868	6	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	4868	7	Biology	Biology	NNP
cord-001835-0s7ok4uw	4868	8	on	on	IN
cord-001835-0s7ok4uw	4868	9	Infectious	Infectious	NNP
cord-001835-0s7ok4uw	4868	10	Disease	Disease	NNP
cord-001835-0s7ok4uw	4868	11	,	,	,
cord-001835-0s7ok4uw	4868	12	2	2	CD
cord-001835-0s7ok4uw	4869	1	The	the	DT
cord-001835-0s7ok4uw	4869	2	Department	Department	NNP
cord-001835-0s7ok4uw	4869	3	of	of	IN
cord-001835-0s7ok4uw	4869	4	Cell	Cell	NNP
cord-001835-0s7ok4uw	4869	5	Biology	Biology	NNP
cord-001835-0s7ok4uw	4869	6	and	and	CC
cord-001835-0s7ok4uw	4869	7	Genetics	Genetics	NNP
cord-001835-0s7ok4uw	4870	1	The	the	DT
cord-001835-0s7ok4uw	4870	2	directly	directly	JJ
cord-001835-0s7ok4uw	4870	3	interaction	interaction	NN
cord-001835-0s7ok4uw	4870	4	between	between	IN
cord-001835-0s7ok4uw	4870	5	PreS1	PreS1	NNP
cord-001835-0s7ok4uw	4870	6	of	of	IN
cord-001835-0s7ok4uw	4870	7	Human	human	JJ
cord-001835-0s7ok4uw	4870	8	virus	virus	NN
cord-001835-0s7ok4uw	4870	9	B	b	NN
cord-001835-0s7ok4uw	4870	10	and	and	CC
cord-001835-0s7ok4uw	4870	11	Human	Human	NNP
cord-001835-0s7ok4uw	4870	12	Heat	Heat	NNP
cord-001835-0s7ok4uw	4870	13	Shock	Shock	NNP
cord-001835-0s7ok4uw	4870	14	protein	protein	NN
cord-001835-0s7ok4uw	4870	15	70	70	CD
cord-001835-0s7ok4uw	4870	16	(	(	-LRB-
cord-001835-0s7ok4uw	4870	17	HSP70	HSP70	NNP
cord-001835-0s7ok4uw	4870	18	)	)	-RRB-
cord-001835-0s7ok4uw	4870	19	.	.	.
cord-001835-0s7ok4uw	4871	1	Hepatitis	Hepatitis	NNP
cord-001835-0s7ok4uw	4871	2	B	B	NNP
cord-001835-0s7ok4uw	4871	3	virus	virus	NN
cord-001835-0s7ok4uw	4871	4	(	(	-LRB-
cord-001835-0s7ok4uw	4871	5	HBV	HBV	NNP
cord-001835-0s7ok4uw	4871	6	)	)	-RRB-
cord-001835-0s7ok4uw	4871	7	has	have	VBZ
cord-001835-0s7ok4uw	4871	8	infected	infect	VBN
cord-001835-0s7ok4uw	4871	9	2	2	CD
cord-001835-0s7ok4uw	4871	10	billion	billion	CD
cord-001835-0s7ok4uw	4871	11	people	people	NNS
cord-001835-0s7ok4uw	4871	12	worldwide	worldwide	RB
cord-001835-0s7ok4uw	4871	13	,	,	,
cord-001835-0s7ok4uw	4871	14	and	and	CC
cord-001835-0s7ok4uw	4871	15	350	350	CD
cord-001835-0s7ok4uw	4871	16	million	million	CD
cord-001835-0s7ok4uw	4871	17	of	of	IN
cord-001835-0s7ok4uw	4871	18	them	-PRON-	PRP
cord-001835-0s7ok4uw	4871	19	are	be	VBP
cord-001835-0s7ok4uw	4871	20	chronically	chronically	RB
cord-001835-0s7ok4uw	4871	21	infected	infect	VBN
cord-001835-0s7ok4uw	4871	22	.	.	.
cord-001835-0s7ok4uw	4872	1	The	the	DT
cord-001835-0s7ok4uw	4872	2	chronic	chronic	JJ
cord-001835-0s7ok4uw	4872	3	virus	virus	NN
cord-001835-0s7ok4uw	4872	4	infection	infection	NN
cord-001835-0s7ok4uw	4872	5	,	,	,
cord-001835-0s7ok4uw	4872	6	a	a	DT
cord-001835-0s7ok4uw	4872	7	major	major	JJ
cord-001835-0s7ok4uw	4872	8	public	public	JJ
cord-001835-0s7ok4uw	4872	9	health	health	NN
cord-001835-0s7ok4uw	4872	10	problem	problem	NN
cord-001835-0s7ok4uw	4872	11	worldwide	worldwide	RB
cord-001835-0s7ok4uw	4872	12	,	,	,
cord-001835-0s7ok4uw	4872	13	leads	lead	VBZ
cord-001835-0s7ok4uw	4872	14	to	to	TO
cord-001835-0s7ok4uw	4872	15	bout	bout	VB
cord-001835-0s7ok4uw	4872	16	two	two	CD
cord-001835-0s7ok4uw	4872	17	-	-	HYPH
cord-001835-0s7ok4uw	4872	18	thirds	third	NNS
cord-001835-0s7ok4uw	4872	19	of	of	IN
cord-001835-0s7ok4uw	4872	20	hepatocellular	hepatocellular	JJ
cord-001835-0s7ok4uw	4872	21	carcinoma	carcinoma	NN
cord-001835-0s7ok4uw	4872	22	(	(	-LRB-
cord-001835-0s7ok4uw	4872	23	HCC	HCC	NNP
cord-001835-0s7ok4uw	4872	24	)	)	-RRB-
cord-001835-0s7ok4uw	4872	25	.	.	.
cord-001835-0s7ok4uw	4873	1	The	the	DT
cord-001835-0s7ok4uw	4873	2	HBV	HBV	NNP
cord-001835-0s7ok4uw	4873	3	envelope	envelope	NN
cord-001835-0s7ok4uw	4873	4	consists	consist	VBZ
cord-001835-0s7ok4uw	4873	5	of	of	IN
cord-001835-0s7ok4uw	4873	6	the	the	DT
cord-001835-0s7ok4uw	4873	7	large	large	JJ
cord-001835-0s7ok4uw	4873	8	(	(	-LRB-
cord-001835-0s7ok4uw	4873	9	L	L	NNP
cord-001835-0s7ok4uw	4873	10	)	)	-RRB-
cord-001835-0s7ok4uw	4873	11	,	,	,
cord-001835-0s7ok4uw	4873	12	middle	middle	JJ
cord-001835-0s7ok4uw	4873	13	(	(	-LRB-
cord-001835-0s7ok4uw	4873	14	M	M	NNP
cord-001835-0s7ok4uw	4873	15	)	)	-RRB-
cord-001835-0s7ok4uw	4873	16	and	and	CC
cord-001835-0s7ok4uw	4873	17	small	small	JJ
cord-001835-0s7ok4uw	4873	18	(	(	-LRB-
cord-001835-0s7ok4uw	4873	19	S	s	NN
cord-001835-0s7ok4uw	4873	20	)	)	-RRB-
cord-001835-0s7ok4uw	4873	21	envelope	envelope	NN
cord-001835-0s7ok4uw	4873	22	proteins	protein	NNS
cord-001835-0s7ok4uw	4873	23	,	,	,
cord-001835-0s7ok4uw	4873	24	which	which	WDT
cord-001835-0s7ok4uw	4873	25	contain	contain	VBP
cord-001835-0s7ok4uw	4873	26	preS1-preS2-S	preS1-preS2-S	NNP
cord-001835-0s7ok4uw	4873	27	,	,	,
cord-001835-0s7ok4uw	4873	28	preS2-S	preS2-S	NNP
cord-001835-0s7ok4uw	4873	29	,	,	,
cord-001835-0s7ok4uw	4873	30	and	and	CC
cord-001835-0s7ok4uw	4873	31	S	S	NNP
cord-001835-0s7ok4uw	4873	32	domain	domain	NN
cord-001835-0s7ok4uw	4873	33	alone	alone	RB
cord-001835-0s7ok4uw	4873	34	,	,	,
cord-001835-0s7ok4uw	4873	35	respectively	respectively	RB
cord-001835-0s7ok4uw	4873	36	[	[	-LRB-
cord-001835-0s7ok4uw	4873	37	2	2	CD
cord-001835-0s7ok4uw	4873	38	]	]	-RRB-
cord-001835-0s7ok4uw	4873	39	.	.	.
cord-001835-0s7ok4uw	4874	1	The	the	DT
cord-001835-0s7ok4uw	4874	2	preS1	preS1	JJS
cord-001835-0s7ok4uw	4874	3	domain	domain	NN
cord-001835-0s7ok4uw	4874	4	is	be	VBZ
cord-001835-0s7ok4uw	4874	5	believed	believe	VBN
cord-001835-0s7ok4uw	4874	6	to	to	TO
cord-001835-0s7ok4uw	4874	7	mediate	mediate	VB
cord-001835-0s7ok4uw	4874	8	virus	virus	NN
cord-001835-0s7ok4uw	4874	9	attachment	attachment	NN
cord-001835-0s7ok4uw	4874	10	to	to	IN
cord-001835-0s7ok4uw	4874	11	the	the	DT
cord-001835-0s7ok4uw	4874	12	high	high	JJ
cord-001835-0s7ok4uw	4874	13	-	-	HYPH
cord-001835-0s7ok4uw	4874	14	affinity	affinity	NN
cord-001835-0s7ok4uw	4874	15	receptor	receptor	NN
cord-001835-0s7ok4uw	4874	16	.	.	.
cord-001835-0s7ok4uw	4875	1	Yan	Yan	NNP
cord-001835-0s7ok4uw	4875	2	et	et	NNP
cord-001835-0s7ok4uw	4875	3	al	al	NNP
cord-001835-0s7ok4uw	4875	4	employed	employ	VBD
cord-001835-0s7ok4uw	4875	5	a	a	DT
cord-001835-0s7ok4uw	4875	6	novel	novel	JJ
cord-001835-0s7ok4uw	4875	7	technique	technique	NN
cord-001835-0s7ok4uw	4875	8	to	to	TO
cord-001835-0s7ok4uw	4875	9	propose	propose	VB
cord-001835-0s7ok4uw	4875	10	sodium	sodium	NN
cord-001835-0s7ok4uw	4875	11	taurocholate	taurocholate	NNP
cord-001835-0s7ok4uw	4875	12	co	co	JJ
cord-001835-0s7ok4uw	4875	13	-	-	JJ
cord-001835-0s7ok4uw	4875	14	transporting	transporting	JJ
cord-001835-0s7ok4uw	4875	15	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	4875	16	(	(	-LRB-
cord-001835-0s7ok4uw	4875	17	NTCP	NTCP	NNP
cord-001835-0s7ok4uw	4875	18	)	)	-RRB-
cord-001835-0s7ok4uw	4875	19	as	as	IN
cord-001835-0s7ok4uw	4875	20	the	the	DT
cord-001835-0s7ok4uw	4875	21	candidate	candidate	NN
cord-001835-0s7ok4uw	4875	22	HBV	HBV	NNP
cord-001835-0s7ok4uw	4875	23	receptor	receptor	NN
cord-001835-0s7ok4uw	4875	24	,	,	,
cord-001835-0s7ok4uw	4875	25	and	and	CC
cord-001835-0s7ok4uw	4875	26	consequently	consequently	RB
cord-001835-0s7ok4uw	4875	27	,	,	,
cord-001835-0s7ok4uw	4875	28	NTCP	NTCP	NNP
cord-001835-0s7ok4uw	4875	29	is	be	VBZ
cord-001835-0s7ok4uw	4875	30	a	a	DT
cord-001835-0s7ok4uw	4875	31	target	target	NN
cord-001835-0s7ok4uw	4875	32	for	for	IN
cord-001835-0s7ok4uw	4875	33	a	a	DT
cord-001835-0s7ok4uw	4875	34	new	new	JJ
cord-001835-0s7ok4uw	4875	35	family	family	NN
cord-001835-0s7ok4uw	4875	36	of	of	IN
cord-001835-0s7ok4uw	4875	37	anti	anti	JJ
cord-001835-0s7ok4uw	4875	38	-	-	JJ
cord-001835-0s7ok4uw	4875	39	HBV	hbv	JJ
cord-001835-0s7ok4uw	4875	40	agents	agent	NNS
cord-001835-0s7ok4uw	4875	41	[	[	-LRB-
cord-001835-0s7ok4uw	4875	42	3	3	CD
cord-001835-0s7ok4uw	4875	43	]	]	-RRB-
cord-001835-0s7ok4uw	4875	44	.	.	.
cord-001835-0s7ok4uw	4876	1	Whereas	whereas	IN
cord-001835-0s7ok4uw	4876	2	,	,	,
cord-001835-0s7ok4uw	4876	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	4876	4	remains	remain	VBZ
cord-001835-0s7ok4uw	4876	5	a	a	DT
cord-001835-0s7ok4uw	4876	6	query	query	NN
cord-001835-0s7ok4uw	4876	7	to	to	TO
cord-001835-0s7ok4uw	4876	8	clarify	clarify	VB
cord-001835-0s7ok4uw	4876	9	that	that	IN
cord-001835-0s7ok4uw	4876	10	NTCP	NTCP	NNP
cord-001835-0s7ok4uw	4876	11	is	be	VBZ
cord-001835-0s7ok4uw	4876	12	the	the	DT
cord-001835-0s7ok4uw	4876	13	only	only	JJ
cord-001835-0s7ok4uw	4876	14	or	or	CC
cord-001835-0s7ok4uw	4876	15	major	major	JJ
cord-001835-0s7ok4uw	4876	16	HBV	HBV	NNP
cord-001835-0s7ok4uw	4876	17	receptor	receptor	NN
cord-001835-0s7ok4uw	4876	18	in	in	IN
cord-001835-0s7ok4uw	4876	19	vivo	vivo	NNP
cord-001835-0s7ok4uw	4876	20	.	.	.
cord-001835-0s7ok4uw	4877	1	To	to	TO
cord-001835-0s7ok4uw	4877	2	illuminate	illuminate	VB
cord-001835-0s7ok4uw	4877	3	if	if	IN
cord-001835-0s7ok4uw	4877	4	other	other	JJ
cord-001835-0s7ok4uw	4877	5	host	host	NN
cord-001835-0s7ok4uw	4877	6	proteins	protein	NNS
cord-001835-0s7ok4uw	4877	7	cooperatively	cooperatively	RB
cord-001835-0s7ok4uw	4877	8	participate	participate	VBP
cord-001835-0s7ok4uw	4877	9	the	the	DT
cord-001835-0s7ok4uw	4877	10	HBV	HBV	NNP
cord-001835-0s7ok4uw	4877	11	infection	infection	NN
cord-001835-0s7ok4uw	4877	12	,	,	,
cord-001835-0s7ok4uw	4877	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	4877	14	detect	detect	VBP
cord-001835-0s7ok4uw	4877	15	the	the	DT
cord-001835-0s7ok4uw	4877	16	interaction	interaction	NN
cord-001835-0s7ok4uw	4877	17	between	between	IN
cord-001835-0s7ok4uw	4877	18	PreS1	PreS1	NNP
cord-001835-0s7ok4uw	4877	19	and	and	CC
cord-001835-0s7ok4uw	4877	20	many	many	JJ
cord-001835-0s7ok4uw	4877	21	candidate	candidate	NN
cord-001835-0s7ok4uw	4877	22	host	host	NN
cord-001835-0s7ok4uw	4877	23	proteins	protein	NNS
cord-001835-0s7ok4uw	4877	24	.	.	.
cord-001835-0s7ok4uw	4878	1	Fortunately	fortunately	RB
cord-001835-0s7ok4uw	4878	2	,	,	,
cord-001835-0s7ok4uw	4878	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4878	4	have	have	VBP
cord-001835-0s7ok4uw	4878	5	found	find	VBN
cord-001835-0s7ok4uw	4878	6	that	that	IN
cord-001835-0s7ok4uw	4878	7	the	the	DT
cord-001835-0s7ok4uw	4878	8	human	human	JJ
cord-001835-0s7ok4uw	4878	9	heat	heat	NN
cord-001835-0s7ok4uw	4878	10	shocking	shock	VBG
cord-001835-0s7ok4uw	4878	11	protein	protein	NN
cord-001835-0s7ok4uw	4878	12	70	70	CD
cord-001835-0s7ok4uw	4878	13	(	(	-LRB-
cord-001835-0s7ok4uw	4878	14	HSP70	HSP70	NNP
cord-001835-0s7ok4uw	4878	15	)	)	-RRB-
cord-001835-0s7ok4uw	4878	16	could	could	MD
cord-001835-0s7ok4uw	4878	17	directly	directly	RB
cord-001835-0s7ok4uw	4878	18	interact	interact	VB
cord-001835-0s7ok4uw	4878	19	with	with	IN
cord-001835-0s7ok4uw	4878	20	the	the	DT
cord-001835-0s7ok4uw	4878	21	PreS1	PreS1	NNP
cord-001835-0s7ok4uw	4878	22	domain	domain	NN
cord-001835-0s7ok4uw	4878	23	of	of	IN
cord-001835-0s7ok4uw	4878	24	the	the	DT
cord-001835-0s7ok4uw	4878	25	HBV	HBV	NNP
cord-001835-0s7ok4uw	4878	26	virus	virus	NN
cord-001835-0s7ok4uw	4878	27	protein	protein	NN
cord-001835-0s7ok4uw	4878	28	.	.	.
cord-001835-0s7ok4uw	4879	1	Both	both	DT
cord-001835-0s7ok4uw	4879	2	the	the	DT
cord-001835-0s7ok4uw	4879	3	pull	pull	NN
cord-001835-0s7ok4uw	4879	4	down	down	RP
cord-001835-0s7ok4uw	4879	5	and	and	CC
cord-001835-0s7ok4uw	4879	6	the	the	DT
cord-001835-0s7ok4uw	4879	7	size	size	NN
cord-001835-0s7ok4uw	4879	8	exclusion	exclusion	NN
cord-001835-0s7ok4uw	4879	9	chromatography	chromatography	NN
cord-001835-0s7ok4uw	4879	10	experiments	experiment	NNS
cord-001835-0s7ok4uw	4879	11	verify	verify	VBP
cord-001835-0s7ok4uw	4879	12	that	that	IN
cord-001835-0s7ok4uw	4879	13	the	the	DT
cord-001835-0s7ok4uw	4879	14	GRP78	GRP78	NNP
cord-001835-0s7ok4uw	4879	15	have	have	VBP
cord-001835-0s7ok4uw	4879	16	the	the	DT
cord-001835-0s7ok4uw	4879	17	ability	ability	NN
cord-001835-0s7ok4uw	4879	18	binding	bind	VBG
cord-001835-0s7ok4uw	4879	19	to	to	IN
cord-001835-0s7ok4uw	4879	20	PreS1	PreS1	NNP
cord-001835-0s7ok4uw	4879	21	.	.	.
cord-001835-0s7ok4uw	4880	1	Whereas	whereas	IN
cord-001835-0s7ok4uw	4880	2	,	,	,
cord-001835-0s7ok4uw	4880	3	whether	whether	IN
cord-001835-0s7ok4uw	4880	4	the	the	DT
cord-001835-0s7ok4uw	4880	5	interaction	interaction	NN
cord-001835-0s7ok4uw	4880	6	between	between	IN
cord-001835-0s7ok4uw	4880	7	HSP70	HSP70	NNP
cord-001835-0s7ok4uw	4880	8	and	and	CC
cord-001835-0s7ok4uw	4880	9	PreS1	PreS1	NNP
cord-001835-0s7ok4uw	4880	10	relates	relate	VBZ
cord-001835-0s7ok4uw	4880	11	to	to	IN
cord-001835-0s7ok4uw	4880	12	the	the	DT
cord-001835-0s7ok4uw	4880	13	HBV	HBV	NNP
cord-001835-0s7ok4uw	4880	14	infection	infection	NN
cord-001835-0s7ok4uw	4880	15	need	need	VBP
cord-001835-0s7ok4uw	4880	16	further	further	JJ
cord-001835-0s7ok4uw	4880	17	experiments	experiment	NNS
cord-001835-0s7ok4uw	4880	18	to	to	TO
cord-001835-0s7ok4uw	4880	19	clarify	clarify	VB
cord-001835-0s7ok4uw	4880	20	.	.	.
cord-001835-0s7ok4uw	4881	1	4	4	LS
cord-001835-0s7ok4uw	4882	1	The	the	DT
cord-001835-0s7ok4uw	4882	2	member	member	NN
cord-001835-0s7ok4uw	4882	3	sponsorship	sponsorship	NN
cord-001835-0s7ok4uw	4882	4	In	in	IN
cord-001835-0s7ok4uw	4882	5	the	the	DT
cord-001835-0s7ok4uw	4882	6	vast	vast	JJ
cord-001835-0s7ok4uw	4882	7	world	world	NN
cord-001835-0s7ok4uw	4882	8	of	of	IN
cord-001835-0s7ok4uw	4882	9	naturally	naturally	RB
cord-001835-0s7ok4uw	4882	10	occurring	occur	VBG
cord-001835-0s7ok4uw	4882	11	peptides	peptide	NNS
cord-001835-0s7ok4uw	4882	12	,	,	,
cord-001835-0s7ok4uw	4882	13	where	where	WRB
cord-001835-0s7ok4uw	4882	14	more	more	JJR
cord-001835-0s7ok4uw	4882	15	than	than	IN
cord-001835-0s7ok4uw	4882	16	7000	7000	CD
cord-001835-0s7ok4uw	4882	17	peptides	peptide	NNS
cord-001835-0s7ok4uw	4882	18	are	be	VBP
cord-001835-0s7ok4uw	4882	19	known	know	VBN
cord-001835-0s7ok4uw	4882	20	and	and	CC
cord-001835-0s7ok4uw	4882	21	approximately	approximately	RB
cord-001835-0s7ok4uw	4882	22	140	140	CD
cord-001835-0s7ok4uw	4882	23	peptide	peptide	NN
cord-001835-0s7ok4uw	4882	24	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	4882	25	are	be	VBP
cord-001835-0s7ok4uw	4882	26	currently	currently	RB
cord-001835-0s7ok4uw	4882	27	being	be	VBG
cord-001835-0s7ok4uw	4882	28	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	4882	29	in	in	IN
cord-001835-0s7ok4uw	4882	30	clinical	clinical	JJ
cord-001835-0s7ok4uw	4882	31	trials	trial	NNS
cord-001835-0s7ok4uw	4882	32	(	(	-LRB-
cord-001835-0s7ok4uw	4882	33	Fosgerau	Fosgerau	NNP
cord-001835-0s7ok4uw	4882	34	&	&	CC
cord-001835-0s7ok4uw	4882	35	Hoffmann	Hoffmann	NNP
cord-001835-0s7ok4uw	4882	36	,	,	,
cord-001835-0s7ok4uw	4882	37	2015	2015	CD
cord-001835-0s7ok4uw	4882	38	)	)	-RRB-
cord-001835-0s7ok4uw	4882	39	,	,	,
cord-001835-0s7ok4uw	4882	40	the	the	DT
cord-001835-0s7ok4uw	4882	41	rapid	rapid	JJ
cord-001835-0s7ok4uw	4882	42	and	and	CC
cord-001835-0s7ok4uw	4882	43	accurate	accurate	JJ
cord-001835-0s7ok4uw	4882	44	determination	determination	NN
cord-001835-0s7ok4uw	4882	45	of	of	IN
cord-001835-0s7ok4uw	4882	46	their	-PRON-	PRP$
cord-001835-0s7ok4uw	4882	47	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	4882	48	properties	property	NNS
cord-001835-0s7ok4uw	4882	49	is	be	VBZ
cord-001835-0s7ok4uw	4882	50	key	key	JJ
cord-001835-0s7ok4uw	4882	51	in	in	IN
cord-001835-0s7ok4uw	4882	52	peptide	peptide	JJ
cord-001835-0s7ok4uw	4882	53	drug	drug	NN
cord-001835-0s7ok4uw	4882	54	discovery	discovery	NN
cord-001835-0s7ok4uw	4882	55	.	.	.
cord-001835-0s7ok4uw	4883	1	Among	among	IN
cord-001835-0s7ok4uw	4883	2	these	these	DT
cord-001835-0s7ok4uw	4883	3	properties	property	NNS
cord-001835-0s7ok4uw	4883	4	,	,	,
cord-001835-0s7ok4uw	4883	5	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	4883	6	is	be	VBZ
cord-001835-0s7ok4uw	4883	7	crucial	crucial	JJ
cord-001835-0s7ok4uw	4883	8	for	for	IN
cord-001835-0s7ok4uw	4883	9	understanding	understand	VBG
cord-001835-0s7ok4uw	4883	10	molecular	molecular	JJ
cord-001835-0s7ok4uw	4883	11	recognition	recognition	NN
cord-001835-0s7ok4uw	4883	12	and	and	CC
cord-001835-0s7ok4uw	4883	13	biomolecular	biomolecular	JJ
cord-001835-0s7ok4uw	4883	14	aggregation	aggregation	NN
cord-001835-0s7ok4uw	4883	15	.	.	.
cord-001835-0s7ok4uw	4884	1	Hence	hence	RB
cord-001835-0s7ok4uw	4884	2	,	,	,
cord-001835-0s7ok4uw	4884	3	there	there	EX
cord-001835-0s7ok4uw	4884	4	is	be	VBZ
cord-001835-0s7ok4uw	4884	5	a	a	DT
cord-001835-0s7ok4uw	4884	6	great	great	JJ
cord-001835-0s7ok4uw	4884	7	interest	interest	NN
cord-001835-0s7ok4uw	4884	8	in	in	IN
cord-001835-0s7ok4uw	4884	9	determining	determine	VBG
cord-001835-0s7ok4uw	4884	10	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	4884	11	scales	scale	NNS
cord-001835-0s7ok4uw	4884	12	for	for	IN
cord-001835-0s7ok4uw	4884	13	amino	amino	NN
cord-001835-0s7ok4uw	4884	14	acid	acid	NN
cord-001835-0s7ok4uw	4884	15	structures	structure	NNS
cord-001835-0s7ok4uw	4884	16	.	.	.
cord-001835-0s7ok4uw	4885	1	In	in	IN
cord-001835-0s7ok4uw	4885	2	this	this	DT
cord-001835-0s7ok4uw	4885	3	work	work	NN
cord-001835-0s7ok4uw	4885	4	,	,	,
cord-001835-0s7ok4uw	4885	5	octanol	octanol	NN
cord-001835-0s7ok4uw	4885	6	/	/	SYM
cord-001835-0s7ok4uw	4885	7	water	water	NN
cord-001835-0s7ok4uw	4885	8	partition	partition	NN
cord-001835-0s7ok4uw	4885	9	(	(	-LRB-
cord-001835-0s7ok4uw	4885	10	log	log	NN
cord-001835-0s7ok4uw	4885	11	P	P	NNP
cord-001835-0s7ok4uw	4885	12	)	)	-RRB-
cord-001835-0s7ok4uw	4885	13	and	and	CC
cord-001835-0s7ok4uw	4885	14	octanol	octanol	NN
cord-001835-0s7ok4uw	4885	15	/	/	SYM
cord-001835-0s7ok4uw	4885	16	water	water	NN
cord-001835-0s7ok4uw	4885	17	distribution	distribution	NN
cord-001835-0s7ok4uw	4885	18	(	(	-LRB-
cord-001835-0s7ok4uw	4885	19	log	log	NN
cord-001835-0s7ok4uw	4885	20	DpH	dph	NN
cord-001835-0s7ok4uw	4885	21	,	,	,
cord-001835-0s7ok4uw	4885	22	Fig	Fig	NNP
cord-001835-0s7ok4uw	4885	23	.	.	NNP
cord-001835-0s7ok4uw	4885	24	1	1	CD
cord-001835-0s7ok4uw	4885	25	)	)	-RRB-
cord-001835-0s7ok4uw	4885	26	of	of	IN
cord-001835-0s7ok4uw	4885	27	N	n	CD
cord-001835-0s7ok4uw	4885	28	-	-	HYPH
cord-001835-0s7ok4uw	4885	29	acetyl	acetyl	NNP
cord-001835-0s7ok4uw	4885	30	-	-	HYPH
cord-001835-0s7ok4uw	4885	31	L	l	NN
cord-001835-0s7ok4uw	4885	32	-	-	HYPH
cord-001835-0s7ok4uw	4885	33	amino	amino	NN
cord-001835-0s7ok4uw	4885	34	-	-	HYPH
cord-001835-0s7ok4uw	4885	35	acid	acid	NN
cord-001835-0s7ok4uw	4885	36	methyl	methyl	NN
cord-001835-0s7ok4uw	4885	37	amides	amide	NNS
cord-001835-0s7ok4uw	4885	38	were	be	VBD
cord-001835-0s7ok4uw	4885	39	determined	determine	VBN
cord-001835-0s7ok4uw	4885	40	by	by	IN
cord-001835-0s7ok4uw	4885	41	means	mean	NNS
cord-001835-0s7ok4uw	4885	42	of	of	IN
cord-001835-0s7ok4uw	4885	43	quantum	quantum	JJ
cord-001835-0s7ok4uw	4885	44	mechanical	mechanical	JJ
cord-001835-0s7ok4uw	4885	45	IEF	IEF	NNP
cord-001835-0s7ok4uw	4885	46	-	-	HYPH
cord-001835-0s7ok4uw	4885	47	MST	MST	NNP
cord-001835-0s7ok4uw	4885	48	solvation	solvation	NN
cord-001835-0s7ok4uw	4885	49	calculations	calculation	NNS
cord-001835-0s7ok4uw	4885	50	taking	take	VBG
cord-001835-0s7ok4uw	4885	51	into	into	IN
cord-001835-0s7ok4uw	4885	52	account	account	NN
cord-001835-0s7ok4uw	4885	53	the	the	DT
cord-001835-0s7ok4uw	4885	54	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	4885	55	conformational	conformational	JJ
cord-001835-0s7ok4uw	4885	56	preferences	preference	NNS
cord-001835-0s7ok4uw	4885	57	of	of	IN
cord-001835-0s7ok4uw	4885	58	each	each	DT
cord-001835-0s7ok4uw	4885	59	amino	amino	NN
cord-001835-0s7ok4uw	4885	60	acid	acid	NN
cord-001835-0s7ok4uw	4885	61	according	accord	VBG
cord-001835-0s7ok4uw	4885	62	to	to	IN
cord-001835-0s7ok4uw	4885	63	Dunbrack	Dunbrack	NNP
cord-001835-0s7ok4uw	4885	64	's	's	POS
cord-001835-0s7ok4uw	4885	65	libraries	library	NNS
cord-001835-0s7ok4uw	4885	66	(	(	-LRB-
cord-001835-0s7ok4uw	4885	67	Dunbrack	Dunbrack	NNP
cord-001835-0s7ok4uw	4885	68	&	&	CC
cord-001835-0s7ok4uw	4885	69	Karplus	Karplus	NNP
cord-001835-0s7ok4uw	4885	70	,	,	,
cord-001835-0s7ok4uw	4885	71	1993	1993	CD
cord-001835-0s7ok4uw	4885	72	;	;	:
cord-001835-0s7ok4uw	4885	73	1994	1994	CD
cord-001835-0s7ok4uw	4885	74	)	)	-RRB-
cord-001835-0s7ok4uw	4885	75	.	.	.
cord-001835-0s7ok4uw	4886	1	The	the	DT
cord-001835-0s7ok4uw	4886	2	results	result	NNS
cord-001835-0s7ok4uw	4886	3	reveal	reveal	VBP
cord-001835-0s7ok4uw	4886	4	log	log	NN
cord-001835-0s7ok4uw	4886	5	D7.4	D7.4	NNS
cord-001835-0s7ok4uw	4886	6	differences	difference	NNS
cord-001835-0s7ok4uw	4886	7	for	for	IN
cord-001835-0s7ok4uw	4886	8	a	a	DT
cord-001835-0s7ok4uw	4886	9	-	-	HYPH
cord-001835-0s7ok4uw	4886	10	helical	helical	JJ
cord-001835-0s7ok4uw	4886	11	and	and	CC
cord-001835-0s7ok4uw	4886	12	b	b	NN
cord-001835-0s7ok4uw	4886	13	-	-	HYPH
cord-001835-0s7ok4uw	4886	14	sheet	sheet	NN
cord-001835-0s7ok4uw	4886	15	conformations	conformation	NNS
cord-001835-0s7ok4uw	4886	16	in	in	IN
cord-001835-0s7ok4uw	4886	17	Arg	Arg	NNP
cord-001835-0s7ok4uw	4886	18	,	,	,
cord-001835-0s7ok4uw	4886	19	Lys	Lys	NNP
cord-001835-0s7ok4uw	4886	20	,	,	,
cord-001835-0s7ok4uw	4886	21	Hid	Hid	NNP
cord-001835-0s7ok4uw	4886	22	,	,	,
cord-001835-0s7ok4uw	4886	23	Asn	Asn	NNP
cord-001835-0s7ok4uw	4886	24	,	,	,
cord-001835-0s7ok4uw	4886	25	Gln	Gln	NNP
cord-001835-0s7ok4uw	4886	26	,	,	,
cord-001835-0s7ok4uw	4886	27	Met	Met	NNP
cord-001835-0s7ok4uw	4886	28	,	,	,
cord-001835-0s7ok4uw	4886	29	Cys	Cys	NNP
cord-001835-0s7ok4uw	4886	30	,	,	,
cord-001835-0s7ok4uw	4886	31	Leu	Leu	NNP
cord-001835-0s7ok4uw	4886	32	and	and	CC
cord-001835-0s7ok4uw	4886	33	Ile	Ile	NNP
cord-001835-0s7ok4uw	4886	34	.	.	.
cord-001835-0s7ok4uw	4887	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	4887	2	,	,	,
cord-001835-0s7ok4uw	4887	3	by	by	IN
cord-001835-0s7ok4uw	4887	4	decomposing	decompose	VBG
cord-001835-0s7ok4uw	4887	5	the	the	DT
cord-001835-0s7ok4uw	4887	6	octanol	octanol	NN
cord-001835-0s7ok4uw	4887	7	/	/	SYM
cord-001835-0s7ok4uw	4887	8	water	water	NN
cord-001835-0s7ok4uw	4887	9	transfer	transfer	NN
cord-001835-0s7ok4uw	4887	10	free	free	JJ
cord-001835-0s7ok4uw	4887	11	energy	energy	NN
cord-001835-0s7ok4uw	4887	12	into	into	IN
cord-001835-0s7ok4uw	4887	13	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	4887	14	and	and	CC
cord-001835-0s7ok4uw	4887	15	non	non	JJ
cord-001835-0s7ok4uw	4887	16	-	-	JJ
cord-001835-0s7ok4uw	4887	17	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	4887	18	components	component	NNS
cord-001835-0s7ok4uw	4887	19	,	,	,
cord-001835-0s7ok4uw	4887	20	we	-PRON-	PRP
cord-001835-0s7ok4uw	4887	21	estimated	estimate	VBD
cord-001835-0s7ok4uw	4887	22	that	that	IN
cord-001835-0s7ok4uw	4887	23	the	the	DT
cord-001835-0s7ok4uw	4887	24	non	non	JJ
cord-001835-0s7ok4uw	4887	25	-	-	JJ
cord-001835-0s7ok4uw	4887	26	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	4887	27	cost	cost	NN
cord-001835-0s7ok4uw	4887	28	of	of	IN
cord-001835-0s7ok4uw	4887	29	transferring	transfer	VBG
cord-001835-0s7ok4uw	4887	30	the	the	DT
cord-001835-0s7ok4uw	4887	31	amino	amino	NN
cord-001835-0s7ok4uw	4887	32	acid	acid	NN
cord-001835-0s7ok4uw	4887	33	side	side	NN
cord-001835-0s7ok4uw	4887	34	chain	chain	NN
cord-001835-0s7ok4uw	4887	35	amounts	amount	VBZ
cord-001835-0s7ok4uw	4887	36	to	to	IN
cord-001835-0s7ok4uw	4887	37	23.9	23.9	CD
cord-001835-0s7ok4uw	4887	38	6	6	CD
cord-001835-0s7ok4uw	4887	39	3.0	3.0	CD
cord-001835-0s7ok4uw	4888	1	cal	cal	NNP
cord-001835-0s7ok4uw	4888	2	/	/	SYM
cord-001835-0s7ok4uw	4888	3	mol	mol	NNP
cord-001835-0s7ok4uw	4888	4	.	.	.
cord-001835-0s7ok4uw	4888	5	Å2	Å2	NNP
cord-001835-0s7ok4uw	4888	6	,	,	,
cord-001835-0s7ok4uw	4888	7	in	in	IN
cord-001835-0s7ok4uw	4888	8	agreement	agreement	NN
cord-001835-0s7ok4uw	4888	9	with	with	IN
cord-001835-0s7ok4uw	4888	10	previous	previous	JJ
cord-001835-0s7ok4uw	4888	11	estimates	estimate	NNS
cord-001835-0s7ok4uw	4888	12	reported	report	VBN
cord-001835-0s7ok4uw	4888	13	in	in	IN
cord-001835-0s7ok4uw	4888	14	the	the	DT
cord-001835-0s7ok4uw	4888	15	literature	literature	NN
cord-001835-0s7ok4uw	4888	16	.	.	.
cord-001835-0s7ok4uw	4889	1	Comparison	comparison	NN
cord-001835-0s7ok4uw	4889	2	of	of	IN
cord-001835-0s7ok4uw	4889	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4889	4	scale	scale	NN
cord-001835-0s7ok4uw	4889	5	with	with	IN
cord-001835-0s7ok4uw	4889	6	other	other	JJ
cord-001835-0s7ok4uw	4889	7	theoretical	theoretical	JJ
cord-001835-0s7ok4uw	4889	8	and	and	CC
cord-001835-0s7ok4uw	4889	9	experimental	experimental	JJ
cord-001835-0s7ok4uw	4889	10	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	4889	11	scales	scale	NNS
cord-001835-0s7ok4uw	4889	12	yields	yield	VBZ
cord-001835-0s7ok4uw	4889	13	satisfactory	satisfactory	JJ
cord-001835-0s7ok4uw	4889	14	results	result	NNS
cord-001835-0s7ok4uw	4889	15	,	,	,
cord-001835-0s7ok4uw	4889	16	leading	lead	VBG
cord-001835-0s7ok4uw	4889	17	to	to	IN
cord-001835-0s7ok4uw	4889	18	correlation	correlation	NN
cord-001835-0s7ok4uw	4889	19	coefficients	coefficient	NNS
cord-001835-0s7ok4uw	4889	20	ranging	range	VBG
cord-001835-0s7ok4uw	4889	21	from	from	IN
cord-001835-0s7ok4uw	4889	22	0.61	0.61	CD
cord-001835-0s7ok4uw	4889	23	to	to	IN
cord-001835-0s7ok4uw	4889	24	0.94	0.94	CD
cord-001835-0s7ok4uw	4889	25	.	.	.
cord-001835-0s7ok4uw	4890	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	4890	2	,	,	,
cord-001835-0s7ok4uw	4890	3	the	the	DT
cord-001835-0s7ok4uw	4890	4	MSTderived	MSTderived	NNP
cord-001835-0s7ok4uw	4890	5	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	4890	6	scale	scale	NN
cord-001835-0s7ok4uw	4890	7	led	lead	VBD
cord-001835-0s7ok4uw	4890	8	to	to	IN
cord-001835-0s7ok4uw	4890	9	significant	significant	JJ
cord-001835-0s7ok4uw	4890	10	correlations	correlation	NNS
cord-001835-0s7ok4uw	4890	11	with	with	IN
cord-001835-0s7ok4uw	4890	12	the	the	DT
cord-001835-0s7ok4uw	4890	13	RP	RP	NNP
cord-001835-0s7ok4uw	4890	14	-	-	HYPH
cord-001835-0s7ok4uw	4890	15	HPLC	HPLC	NNP
cord-001835-0s7ok4uw	4890	16	retention	retention	NN
cord-001835-0s7ok4uw	4890	17	factors	factor	NNS
cord-001835-0s7ok4uw	4890	18	measured	measure	VBN
cord-001835-0s7ok4uw	4890	19	for	for	IN
cord-001835-0s7ok4uw	4890	20	eight	eight	CD
cord-001835-0s7ok4uw	4890	21	decapeptides	decapeptide	NNS
cord-001835-0s7ok4uw	4890	22	(	(	-LRB-
cord-001835-0s7ok4uw	4890	23	r	r	NN
cord-001835-0s7ok4uw	4890	24	5	5	CD
cord-001835-0s7ok4uw	4890	25	0.97	0.97	CD
cord-001835-0s7ok4uw	4890	26	)	)	-RRB-
cord-001835-0s7ok4uw	4890	27	and	and	CC
cord-001835-0s7ok4uw	4890	28	for	for	IN
cord-001835-0s7ok4uw	4890	29	195	195	CD
cord-001835-0s7ok4uw	4890	30	influenza	influenza	NN
cord-001835-0s7ok4uw	4890	31	virus	virus	NN
cord-001835-0s7ok4uw	4890	32	hemagglutinin	hemagglutinin	NN
cord-001835-0s7ok4uw	4890	33	13-mer	13-mer	CD
cord-001835-0s7ok4uw	4890	34	(	(	-LRB-
cord-001835-0s7ok4uw	4890	35	Ac	Ac	NNP
cord-001835-0s7ok4uw	4890	36	-	-	HYPH
cord-001835-0s7ok4uw	4890	37	YPYDVP	YPYDVP	NNP
cord-001835-0s7ok4uw	4890	38	-	-	HYPH
cord-001835-0s7ok4uw	4890	39	DYASLRS	DYASLRS	NNP
cord-001835-0s7ok4uw	4890	40	-	-	HYPH
cord-001835-0s7ok4uw	4890	41	Amide	Amide	NNP
cord-001835-0s7ok4uw	4890	42	)	)	-RRB-
cord-001835-0s7ok4uw	4890	43	peptides	peptide	NNS
cord-001835-0s7ok4uw	4890	44	(	(	-LRB-
cord-001835-0s7ok4uw	4890	45	r	r	NN
cord-001835-0s7ok4uw	4890	46	5	5	CD
cord-001835-0s7ok4uw	4890	47	0.80	0.80	CD
cord-001835-0s7ok4uw	4890	48	)	)	-RRB-
cord-001835-0s7ok4uw	4890	49	.	.	.
cord-001835-0s7ok4uw	4891	1	Finally	finally	RB
cord-001835-0s7ok4uw	4891	2	,	,	,
cord-001835-0s7ok4uw	4891	3	the	the	DT
cord-001835-0s7ok4uw	4891	4	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	4891	5	scale	scale	NN
cord-001835-0s7ok4uw	4891	6	was	be	VBD
cord-001835-0s7ok4uw	4891	7	able	able	JJ
cord-001835-0s7ok4uw	4891	8	to	to	TO
cord-001835-0s7ok4uw	4891	9	reproduce	reproduce	VB
cord-001835-0s7ok4uw	4891	10	the	the	DT
cord-001835-0s7ok4uw	4891	11	experimental	experimental	JJ
cord-001835-0s7ok4uw	4891	12	log	log	NN
cord-001835-0s7ok4uw	4891	13	P	p	NN
cord-001835-0s7ok4uw	4891	14	for	for	IN
cord-001835-0s7ok4uw	4891	15	118	118	CD
cord-001835-0s7ok4uw	4891	16	random	random	JJ
cord-001835-0s7ok4uw	4891	17	neutral	neutral	JJ
cord-001835-0s7ok4uw	4891	18	peptides	peptide	NNS
cord-001835-0s7ok4uw	4891	19	(	(	-LRB-
cord-001835-0s7ok4uw	4891	20	r	r	NN
cord-001835-0s7ok4uw	4891	21	5	5	CD
cord-001835-0s7ok4uw	4891	22	0.92	0.92	CD
cord-001835-0s7ok4uw	4891	23	)	)	-RRB-
cord-001835-0s7ok4uw	4891	24	and	and	CC
cord-001835-0s7ok4uw	4891	25	log	log	VB
cord-001835-0s7ok4uw	4891	26	D7.4	D7.4	NNS
cord-001835-0s7ok4uw	4891	27	for	for	IN
cord-001835-0s7ok4uw	4891	28	'	'	CD
cord-001835-0s7ok4uw	4891	29	01:15	01:15	CD
cord-001835-0s7ok4uw	4891	30	random	random	JJ
cord-001835-0s7ok4uw	4891	31	charged	charge	VBN
cord-001835-0s7ok4uw	4891	32	peptides	peptide	NNS
cord-001835-0s7ok4uw	4891	33	(	(	-LRB-
cord-001835-0s7ok4uw	4891	34	r	r	NN
cord-001835-0s7ok4uw	4891	35	5	5	CD
cord-001835-0s7ok4uw	4891	36	0.95	0.95	CD
cord-001835-0s7ok4uw	4891	37	)	)	-RRB-
cord-001835-0s7ok4uw	4891	38	,	,	,
cord-001835-0s7ok4uw	4891	39	Fig	Fig	NNP
cord-001835-0s7ok4uw	4891	40	.	.	.
cord-001835-0s7ok4uw	4892	1	2	2	LS
cord-001835-0s7ok4uw	4892	2	.	.	.
cord-001835-0s7ok4uw	4893	1	Future	future	JJ
cord-001835-0s7ok4uw	4893	2	studies	study	NNS
cord-001835-0s7ok4uw	4893	3	will	will	MD
cord-001835-0s7ok4uw	4893	4	address	address	VB
cord-001835-0s7ok4uw	4893	5	the	the	DT
cord-001835-0s7ok4uw	4893	6	application	application	NN
cord-001835-0s7ok4uw	4893	7	of	of	IN
cord-001835-0s7ok4uw	4893	8	this	this	DT
cord-001835-0s7ok4uw	4893	9	methodology	methodology	NN
cord-001835-0s7ok4uw	4893	10	to	to	IN
cord-001835-0s7ok4uw	4893	11	nonproteogenic	nonproteogenic	JJ
cord-001835-0s7ok4uw	4893	12	amino	amino	JJ
cord-001835-0s7ok4uw	4893	13	acids	acid	NNS
cord-001835-0s7ok4uw	4893	14	,	,	,
cord-001835-0s7ok4uw	4893	15	the	the	DT
cord-001835-0s7ok4uw	4893	16	prediction	prediction	NN
cord-001835-0s7ok4uw	4893	17	of	of	IN
cord-001835-0s7ok4uw	4893	18	peptide	peptide	JJ
cord-001835-0s7ok4uw	4893	19	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	4893	20	at	at	IN
cord-001835-0s7ok4uw	4893	21	global	global	JJ
cord-001835-0s7ok4uw	4893	22	and	and	CC
cord-001835-0s7ok4uw	4893	23	atomic	atomic	JJ
cord-001835-0s7ok4uw	4893	24	level	level	NN
cord-001835-0s7ok4uw	4893	25	in	in	IN
cord-001835-0s7ok4uw	4893	26	peptides	peptide	NNS
cord-001835-0s7ok4uw	4893	27	,	,	,
cord-001835-0s7ok4uw	4893	28	and	and	CC
cord-001835-0s7ok4uw	4893	29	the	the	DT
cord-001835-0s7ok4uw	4893	30	scoring	scoring	NN
cord-001835-0s7ok4uw	4893	31	of	of	IN
cord-001835-0s7ok4uw	4893	32	peptide	peptide	NN
cord-001835-0s7ok4uw	4893	33	-	-	HYPH
cord-001835-0s7ok4uw	4893	34	protein	protein	NN
cord-001835-0s7ok4uw	4893	35	interactions	interaction	NNS
cord-001835-0s7ok4uw	4893	36	.	.	.
cord-001835-0s7ok4uw	4894	1	Docking	docking	NN
cord-001835-0s7ok4uw	4894	2	-	-	HYPH
cord-001835-0s7ok4uw	4894	3	based	base	VBN
cord-001835-0s7ok4uw	4894	4	tools	tool	NNS
cord-001835-0s7ok4uw	4894	5	for	for	IN
cord-001835-0s7ok4uw	4894	6	discovery	discovery	NN
cord-001835-0s7ok4uw	4894	7	of	of	IN
cord-001835-0s7ok4uw	4894	8	protein	protein	NN
cord-001835-0s7ok4uw	4894	9	-	-	HYPH
cord-001835-0s7ok4uw	4894	10	protein	protein	NN
cord-001835-0s7ok4uw	4894	11	modulators	modulator	NNS
cord-001835-0s7ok4uw	4894	12	Docking	docking	NN
cord-001835-0s7ok4uw	4894	13	-	-	HYPH
cord-001835-0s7ok4uw	4894	14	based	base	VBN
cord-001835-0s7ok4uw	4894	15	tools	tool	NNS
cord-001835-0s7ok4uw	4894	16	for	for	IN
cord-001835-0s7ok4uw	4894	17	discovery	discovery	NN
cord-001835-0s7ok4uw	4894	18	of	of	IN
cord-001835-0s7ok4uw	4894	19	protein	protein	NN
cord-001835-0s7ok4uw	4894	20	-	-	HYPH
cord-001835-0s7ok4uw	4894	21	protein	protein	NN
cord-001835-0s7ok4uw	4894	22	modulators	modulator	NNS
cord-001835-0s7ok4uw	4894	23	.	.	.
cord-001835-0s7ok4uw	4895	1	Protein	protein	NN
cord-001835-0s7ok4uw	4895	2	-	-	HYPH
cord-001835-0s7ok4uw	4895	3	protein	protein	NN
cord-001835-0s7ok4uw	4895	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	4895	5	(	(	-LRB-
cord-001835-0s7ok4uw	4895	6	PPIs	ppi	NNS
cord-001835-0s7ok4uw	4895	7	)	)	-RRB-
cord-001835-0s7ok4uw	4895	8	play	play	VBP
cord-001835-0s7ok4uw	4895	9	an	an	DT
cord-001835-0s7ok4uw	4895	10	essential	essential	JJ
cord-001835-0s7ok4uw	4895	11	role	role	NN
cord-001835-0s7ok4uw	4895	12	in	in	IN
cord-001835-0s7ok4uw	4895	13	many	many	JJ
cord-001835-0s7ok4uw	4895	14	biological	biological	JJ
cord-001835-0s7ok4uw	4895	15	processes	process	NNS
cord-001835-0s7ok4uw	4895	16	,	,	,
cord-001835-0s7ok4uw	4895	17	including	include	VBG
cord-001835-0s7ok4uw	4895	18	disease	disease	NN
cord-001835-0s7ok4uw	4895	19	conditions	condition	NNS
cord-001835-0s7ok4uw	4895	20	.	.	.
cord-001835-0s7ok4uw	4896	1	Strategies	strategy	NNS
cord-001835-0s7ok4uw	4896	2	to	to	TO
cord-001835-0s7ok4uw	4896	3	modulate	modulate	VB
cord-001835-0s7ok4uw	4896	4	PPIs	ppi	NNS
cord-001835-0s7ok4uw	4896	5	with	with	IN
cord-001835-0s7ok4uw	4896	6	small	small	JJ
cord-001835-0s7ok4uw	4896	7	molecules	molecule	NNS
cord-001835-0s7ok4uw	4896	8	have	have	VBP
cord-001835-0s7ok4uw	4896	9	therefore	therefore	RB
cord-001835-0s7ok4uw	4896	10	attracted	attract	VBN
cord-001835-0s7ok4uw	4896	11	increasing	increase	VBG
cord-001835-0s7ok4uw	4896	12	interest	interest	NN
cord-001835-0s7ok4uw	4896	13	over	over	IN
cord-001835-0s7ok4uw	4896	14	the	the	DT
cord-001835-0s7ok4uw	4896	15	last	last	JJ
cord-001835-0s7ok4uw	4896	16	few	few	JJ
cord-001835-0s7ok4uw	4896	17	years	year	NNS
cord-001835-0s7ok4uw	4896	18	.	.	.
cord-001835-0s7ok4uw	4897	1	Although	although	IN
cord-001835-0s7ok4uw	4897	2	protein	protein	NN
cord-001835-0s7ok4uw	4897	3	-	-	HYPH
cord-001835-0s7ok4uw	4897	4	protein	protein	NN
cord-001835-0s7ok4uw	4897	5	interfaces	interface	NNS
cord-001835-0s7ok4uw	4897	6	(	(	-LRB-
cord-001835-0s7ok4uw	4897	7	PPIfs	ppifs	NN
cord-001835-0s7ok4uw	4897	8	)	)	-RRB-
cord-001835-0s7ok4uw	4897	9	are	be	VBP
cord-001835-0s7ok4uw	4897	10	considered	consider	VBN
cord-001835-0s7ok4uw	4897	11	difficult	difficult	JJ
cord-001835-0s7ok4uw	4897	12	to	to	TO
cord-001835-0s7ok4uw	4897	13	target	target	VB
cord-001835-0s7ok4uw	4897	14	with	with	IN
cord-001835-0s7ok4uw	4897	15	small	small	JJ
cord-001835-0s7ok4uw	4897	16	molecules	molecule	NNS
cord-001835-0s7ok4uw	4897	17	given	give	VBN
cord-001835-0s7ok4uw	4897	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4897	19	lack	lack	NN
cord-001835-0s7ok4uw	4897	20	of	of	IN
cord-001835-0s7ok4uw	4897	21	well	well	RB
cord-001835-0s7ok4uw	4897	22	defined	define	VBN
cord-001835-0s7ok4uw	4897	23	cavities	cavity	NNS
cord-001835-0s7ok4uw	4897	24	.	.	.
cord-001835-0s7ok4uw	4898	1	Successful	successful	JJ
cord-001835-0s7ok4uw	4898	2	PPI	PPI	NNP
cord-001835-0s7ok4uw	4898	3	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4898	4	have	have	VBP
cord-001835-0s7ok4uw	4898	5	been	be	VBN
cord-001835-0s7ok4uw	4898	6	reported	report	VBN
cord-001835-0s7ok4uw	4898	7	into	into	IN
cord-001835-0s7ok4uw	4898	8	transient	transient	JJ
cord-001835-0s7ok4uw	4898	9	cavities	cavity	NNS
cord-001835-0s7ok4uw	4898	10	from	from	IN
cord-001835-0s7ok4uw	4898	11	previously	previously	RB
cord-001835-0s7ok4uw	4898	12	flat	flat	JJ
cord-001835-0s7ok4uw	4898	13	PPIfs	PPIfs	NNP
cord-001835-0s7ok4uw	4898	14	.	.	.
cord-001835-0s7ok4uw	4899	1	Recent	recent	JJ
cord-001835-0s7ok4uw	4899	2	studies	study	NNS
cord-001835-0s7ok4uw	4899	3	emphasize	emphasize	VBP
cord-001835-0s7ok4uw	4899	4	on	on	IN
cord-001835-0s7ok4uw	4899	5	hotspots	hotspot	NNS
cord-001835-0s7ok4uw	4899	6	(	(	-LRB-
cord-001835-0s7ok4uw	4899	7	those	those	DT
cord-001835-0s7ok4uw	4899	8	residues	residue	NNS
cord-001835-0s7ok4uw	4899	9	contribute	contribute	VBP
cord-001835-0s7ok4uw	4899	10	for	for	IN
cord-001835-0s7ok4uw	4899	11	most	most	JJS
cord-001835-0s7ok4uw	4899	12	of	of	IN
cord-001835-0s7ok4uw	4899	13	the	the	DT
cord-001835-0s7ok4uw	4899	14	energy	energy	NN
cord-001835-0s7ok4uw	4899	15	of	of	IN
cord-001835-0s7ok4uw	4899	16	binding	bind	VBG
cord-001835-0s7ok4uw	4899	17	)	)	-RRB-
cord-001835-0s7ok4uw	4899	18	as	as	IN
cord-001835-0s7ok4uw	4899	19	promising	promising	JJ
cord-001835-0s7ok4uw	4899	20	targets	target	NNS
cord-001835-0s7ok4uw	4899	21	for	for	IN
cord-001835-0s7ok4uw	4899	22	the	the	DT
cord-001835-0s7ok4uw	4899	23	modulation	modulation	NN
cord-001835-0s7ok4uw	4899	24	of	of	IN
cord-001835-0s7ok4uw	4899	25	PPI	PPI	NNP
cord-001835-0s7ok4uw	4899	26	.	.	.
cord-001835-0s7ok4uw	4900	1	PyDock	pydock	NN
cord-001835-0s7ok4uw	4900	2	algorithm	algorithm	NN
cord-001835-0s7ok4uw	4900	3	is	be	VBZ
cord-001835-0s7ok4uw	4900	4	one	one	CD
cord-001835-0s7ok4uw	4900	5	of	of	IN
cord-001835-0s7ok4uw	4900	6	the	the	DT
cord-001835-0s7ok4uw	4900	7	few	few	JJ
cord-001835-0s7ok4uw	4900	8	computational	computational	JJ
cord-001835-0s7ok4uw	4900	9	methods	method	NNS
cord-001835-0s7ok4uw	4900	10	that	that	WDT
cord-001835-0s7ok4uw	4900	11	use	use	VBP
cord-001835-0s7ok4uw	4900	12	energy	energy	NN
cord-001835-0s7ok4uw	4900	13	of	of	IN
cord-001835-0s7ok4uw	4900	14	solvation	solvation	NN
cord-001835-0s7ok4uw	4900	15	to	to	TO
cord-001835-0s7ok4uw	4900	16	predict	predict	VB
cord-001835-0s7ok4uw	4900	17	protein	protein	NN
cord-001835-0s7ok4uw	4900	18	-	-	HYPH
cord-001835-0s7ok4uw	4900	19	protein	protein	NN
cord-001835-0s7ok4uw	4900	20	interfaces	interface	NNS
cord-001835-0s7ok4uw	4900	21	and	and	CC
cord-001835-0s7ok4uw	4900	22	hotspots	hotspot	NNS
cord-001835-0s7ok4uw	4900	23	residues	residue	NNS
cord-001835-0s7ok4uw	4900	24	.	.	.
cord-001835-0s7ok4uw	4901	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4901	2	present	present	VBP
cord-001835-0s7ok4uw	4901	3	an	an	DT
cord-001835-0s7ok4uw	4901	4	approach	approach	NN
cord-001835-0s7ok4uw	4901	5	aimed	aim	VBN
cord-001835-0s7ok4uw	4901	6	at	at	IN
cord-001835-0s7ok4uw	4901	7	identifying	identify	VBG
cord-001835-0s7ok4uw	4901	8	hotspots	hotspot	NNS
cord-001835-0s7ok4uw	4901	9	and	and	CC
cord-001835-0s7ok4uw	4901	10	transient	transient	JJ
cord-001835-0s7ok4uw	4901	11	pockets	pocket	NNS
cord-001835-0s7ok4uw	4901	12	from	from	IN
cord-001835-0s7ok4uw	4901	13	predicted	predict	VBN
cord-001835-0s7ok4uw	4901	14	proteinprotein	proteinprotein	NNP
cord-001835-0s7ok4uw	4901	15	interfaces	interface	NNS
cord-001835-0s7ok4uw	4901	16	in	in	IN
cord-001835-0s7ok4uw	4901	17	order	order	NN
cord-001835-0s7ok4uw	4901	18	to	to	TO
cord-001835-0s7ok4uw	4901	19	find	find	VB
cord-001835-0s7ok4uw	4901	20	potential	potential	JJ
cord-001835-0s7ok4uw	4901	21	small	small	JJ
cord-001835-0s7ok4uw	4901	22	molecules	molecule	NNS
cord-001835-0s7ok4uw	4901	23	capable	capable	JJ
cord-001835-0s7ok4uw	4901	24	of	of	IN
cord-001835-0s7ok4uw	4901	25	modulating	modulate	VBG
cord-001835-0s7ok4uw	4901	26	PPIs	ppi	NNS
cord-001835-0s7ok4uw	4901	27	.	.	.
cord-001835-0s7ok4uw	4902	1	The	the	DT
cord-001835-0s7ok4uw	4902	2	method	method	NN
cord-001835-0s7ok4uw	4902	3	uses	use	VBZ
cord-001835-0s7ok4uw	4902	4	pyDock	pyDock	NNP
cord-001835-0s7ok4uw	4902	5	to	to	TO
cord-001835-0s7ok4uw	4902	6	identify	identify	VB
cord-001835-0s7ok4uw	4902	7	PPIfs	ppifs	PRP
cord-001835-0s7ok4uw	4902	8	and	and	CC
cord-001835-0s7ok4uw	4902	9	hotspots	hotspot	NNS
cord-001835-0s7ok4uw	4902	10	and	and	CC
cord-001835-0s7ok4uw	4902	11	molecular	molecular	JJ
cord-001835-0s7ok4uw	4902	12	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	4903	1	(	(	-LRB-
cord-001835-0s7ok4uw	4903	2	MD	MD	NNP
cord-001835-0s7ok4uw	4903	3	)	)	-RRB-
cord-001835-0s7ok4uw	4903	4	techniques	technique	NNS
cord-001835-0s7ok4uw	4903	5	to	to	TO
cord-001835-0s7ok4uw	4903	6	propose	propose	VB
cord-001835-0s7ok4uw	4903	7	putative	putative	JJ
cord-001835-0s7ok4uw	4903	8	transient	transient	JJ
cord-001835-0s7ok4uw	4903	9	cavities	cavity	NNS
cord-001835-0s7ok4uw	4903	10	.	.	.
cord-001835-0s7ok4uw	4904	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4904	2	benchmarked	benchmarke	VBD
cord-001835-0s7ok4uw	4904	3	the	the	DT
cord-001835-0s7ok4uw	4904	4	protocol	protocol	NN
cord-001835-0s7ok4uw	4904	5	in	in	IN
cord-001835-0s7ok4uw	4904	6	a	a	DT
cord-001835-0s7ok4uw	4904	7	small	small	JJ
cord-001835-0s7ok4uw	4904	8	set	set	NN
cord-001835-0s7ok4uw	4904	9	of	of	IN
cord-001835-0s7ok4uw	4904	10	protein	protein	NN
cord-001835-0s7ok4uw	4904	11	-	-	HYPH
cord-001835-0s7ok4uw	4904	12	protein	protein	NN
cord-001835-0s7ok4uw	4904	13	complexes	complex	NNS
cord-001835-0s7ok4uw	4904	14	for	for	IN
cord-001835-0s7ok4uw	4904	15	which	which	WDT
cord-001835-0s7ok4uw	4904	16	both	both	DT
cord-001835-0s7ok4uw	4904	17	structural	structural	JJ
cord-001835-0s7ok4uw	4904	18	data	datum	NNS
cord-001835-0s7ok4uw	4904	19	and	and	CC
cord-001835-0s7ok4uw	4904	20	PPI	PPI	NNP
cord-001835-0s7ok4uw	4904	21	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4904	22	are	be	VBP
cord-001835-0s7ok4uw	4904	23	known	know	VBN
cord-001835-0s7ok4uw	4904	24	.	.	.
cord-001835-0s7ok4uw	4905	1	The	the	DT
cord-001835-0s7ok4uw	4905	2	method	method	NN
cord-001835-0s7ok4uw	4905	3	applies	apply	VBZ
cord-001835-0s7ok4uw	4905	4	to	to	IN
cord-001835-0s7ok4uw	4905	5	the	the	DT
cord-001835-0s7ok4uw	4905	6	unbound	unbound	JJ
cord-001835-0s7ok4uw	4905	7	proteins	protein	NNS
cord-001835-0s7ok4uw	4905	8	of	of	IN
cord-001835-0s7ok4uw	4905	9	the	the	DT
cord-001835-0s7ok4uw	4905	10	complexes	complex	NNS
cord-001835-0s7ok4uw	4905	11	the	the	DT
cord-001835-0s7ok4uw	4905	12	fast	fast	JJ
cord-001835-0s7ok4uw	4905	13	Fourier	Fourier	NNP
cord-001835-0s7ok4uw	4905	14	transform	transform	NN
cord-001835-0s7ok4uw	4905	15	algorithm	algorithm	NN
cord-001835-0s7ok4uw	4905	16	,	,	,
cord-001835-0s7ok4uw	4905	17	followed	follow	VBN
cord-001835-0s7ok4uw	4905	18	by	by	IN
cord-001835-0s7ok4uw	4905	19	the	the	DT
cord-001835-0s7ok4uw	4905	20	energy	energy	NN
cord-001835-0s7ok4uw	4905	21	-	-	HYPH
cord-001835-0s7ok4uw	4905	22	based	base	VBN
cord-001835-0s7ok4uw	4905	23	scoring	scoring	NN
cord-001835-0s7ok4uw	4905	24	from	from	IN
cord-001835-0s7ok4uw	4905	25	pyDock	pyDock	NNP
cord-001835-0s7ok4uw	4905	26	to	to	TO
cord-001835-0s7ok4uw	4905	27	calculate	calculate	VB
cord-001835-0s7ok4uw	4905	28	the	the	DT
cord-001835-0s7ok4uw	4905	29	normalized	normalized	JJ
cord-001835-0s7ok4uw	4905	30	interface	interface	NN
cord-001835-0s7ok4uw	4905	31	propensity	propensity	NN
cord-001835-0s7ok4uw	4905	32	(	(	-LRB-
cord-001835-0s7ok4uw	4905	33	NIP	nip	NN
cord-001835-0s7ok4uw	4905	34	)	)	-RRB-
cord-001835-0s7ok4uw	4905	35	values	value	NNS
cord-001835-0s7ok4uw	4905	36	derived	derive	VBN
cord-001835-0s7ok4uw	4905	37	from	from	IN
cord-001835-0s7ok4uw	4905	38	rigid	rigid	JJ
cord-001835-0s7ok4uw	4905	39	-	-	HYPH
cord-001835-0s7ok4uw	4905	40	body	body	NN
cord-001835-0s7ok4uw	4905	41	protein	protein	NN
cord-001835-0s7ok4uw	4905	42	docking	docking	NN
cord-001835-0s7ok4uw	4905	43	simulations	simulation	NNS
cord-001835-0s7ok4uw	4905	44	to	to	TO
cord-001835-0s7ok4uw	4905	45	predict	predict	VB
cord-001835-0s7ok4uw	4905	46	the	the	DT
cord-001835-0s7ok4uw	4905	47	PPIfs	PPIfs	NNP
cord-001835-0s7ok4uw	4905	48	and	and	CC
cord-001835-0s7ok4uw	4905	49	hotspots	hotspot	NNS
cord-001835-0s7ok4uw	4905	50	residues	residue	NNS
cord-001835-0s7ok4uw	4905	51	without	without	IN
cord-001835-0s7ok4uw	4905	52	any	any	DT
cord-001835-0s7ok4uw	4905	53	prior	prior	JJ
cord-001835-0s7ok4uw	4905	54	structural	structural	JJ
cord-001835-0s7ok4uw	4905	55	knowledge	knowledge	NN
cord-001835-0s7ok4uw	4905	56	of	of	IN
cord-001835-0s7ok4uw	4905	57	the	the	DT
cord-001835-0s7ok4uw	4905	58	complex	complex	NN
cord-001835-0s7ok4uw	4905	59	.	.	.
cord-001835-0s7ok4uw	4906	1	Then	then	RB
cord-001835-0s7ok4uw	4906	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	4906	3	used	use	VBD
cord-001835-0s7ok4uw	4906	4	MD	MD	NNP
cord-001835-0s7ok4uw	4906	5	to	to	TO
cord-001835-0s7ok4uw	4906	6	describe	describe	VB
cord-001835-0s7ok4uw	4906	7	the	the	DT
cord-001835-0s7ok4uw	4906	8	possible	possible	JJ
cord-001835-0s7ok4uw	4906	9	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	4906	10	of	of	IN
cord-001835-0s7ok4uw	4906	11	the	the	DT
cord-001835-0s7ok4uw	4906	12	interacting	interact	VBG
cord-001835-0s7ok4uw	4906	13	proteins	protein	NNS
cord-001835-0s7ok4uw	4906	14	in	in	IN
cord-001835-0s7ok4uw	4906	15	order	order	NN
cord-001835-0s7ok4uw	4906	16	to	to	TO
cord-001835-0s7ok4uw	4906	17	suggest	suggest	VB
cord-001835-0s7ok4uw	4906	18	transient	transient	JJ
cord-001835-0s7ok4uw	4906	19	pockets	pocket	NNS
cord-001835-0s7ok4uw	4906	20	that	that	WDT
cord-001835-0s7ok4uw	4906	21	could	could	MD
cord-001835-0s7ok4uw	4906	22	be	be	VB
cord-001835-0s7ok4uw	4906	23	useful	useful	JJ
cord-001835-0s7ok4uw	4906	24	as	as	IN
cord-001835-0s7ok4uw	4906	25	targets	target	NNS
cord-001835-0s7ok4uw	4906	26	of	of	IN
cord-001835-0s7ok4uw	4906	27	small	small	JJ
cord-001835-0s7ok4uw	4906	28	molecules	molecule	NNS
cord-001835-0s7ok4uw	4906	29	for	for	IN
cord-001835-0s7ok4uw	4906	30	the	the	DT
cord-001835-0s7ok4uw	4906	31	modulation	modulation	NN
cord-001835-0s7ok4uw	4906	32	of	of	IN
cord-001835-0s7ok4uw	4906	33	PPIs	ppi	NNS
cord-001835-0s7ok4uw	4906	34	.	.	.
cord-001835-0s7ok4uw	4907	1	Finally	finally	RB
cord-001835-0s7ok4uw	4907	2	,	,	,
cord-001835-0s7ok4uw	4907	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4907	4	evaluated	evaluate	VBD
cord-001835-0s7ok4uw	4907	5	by	by	IN
cord-001835-0s7ok4uw	4907	6	ligand	ligand	NN
cord-001835-0s7ok4uw	4907	7	docking	docking	NN
cord-001835-0s7ok4uw	4907	8	,	,	,
cord-001835-0s7ok4uw	4907	9	the	the	DT
cord-001835-0s7ok4uw	4907	10	validity	validity	NN
cord-001835-0s7ok4uw	4907	11	of	of	IN
cord-001835-0s7ok4uw	4907	12	predicted	predict	VBN
cord-001835-0s7ok4uw	4907	13	hotspots	hotspot	NNS
cord-001835-0s7ok4uw	4907	14	and	and	CC
cord-001835-0s7ok4uw	4907	15	pockets	pocket	NNS
cord-001835-0s7ok4uw	4907	16	for	for	IN
cord-001835-0s7ok4uw	4907	17	in	in	IN
cord-001835-0s7ok4uw	4907	18	silico	silico	NN
cord-001835-0s7ok4uw	4907	19	drug	drug	NN
cord-001835-0s7ok4uw	4907	20	design	design	NN
cord-001835-0s7ok4uw	4907	21	.	.	.
cord-001835-0s7ok4uw	4908	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4908	2	found	find	VBD
cord-001835-0s7ok4uw	4908	3	that	that	IN
cord-001835-0s7ok4uw	4908	4	the	the	DT
cord-001835-0s7ok4uw	4908	5	NIP	nip	NN
cord-001835-0s7ok4uw	4908	6	-	-	HYPH
cord-001835-0s7ok4uw	4908	7	based	base	VBN
cord-001835-0s7ok4uw	4908	8	method	method	NN
cord-001835-0s7ok4uw	4908	9	from	from	IN
cord-001835-0s7ok4uw	4908	10	pyDock	pyDock	NNP
cord-001835-0s7ok4uw	4908	11	protein	protein	NN
cord-001835-0s7ok4uw	4908	12	-	-	HYPH
cord-001835-0s7ok4uw	4908	13	protein	protein	NN
cord-001835-0s7ok4uw	4908	14	docking	docking	NN
cord-001835-0s7ok4uw	4908	15	identifies	identify	VBZ
cord-001835-0s7ok4uw	4908	16	hotspots	hotspot	NNS
cord-001835-0s7ok4uw	4908	17	residues	residue	NNS
cord-001835-0s7ok4uw	4908	18	that	that	WDT
cord-001835-0s7ok4uw	4908	19	are	be	VBP
cord-001835-0s7ok4uw	4908	20	located	locate	VBN
cord-001835-0s7ok4uw	4908	21	within	within	IN
cord-001835-0s7ok4uw	4908	22	the	the	DT
cord-001835-0s7ok4uw	4908	23	binding	binding	NN
cord-001835-0s7ok4uw	4908	24	site	site	NN
cord-001835-0s7ok4uw	4908	25	of	of	IN
cord-001835-0s7ok4uw	4908	26	known	know	VBN
cord-001835-0s7ok4uw	4908	27	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	4908	28	of	of	IN
cord-001835-0s7ok4uw	4908	29	PPIs	ppi	NNS
cord-001835-0s7ok4uw	4908	30	.	.	.
cord-001835-0s7ok4uw	4909	1	Predicting	predict	VBG
cord-001835-0s7ok4uw	4909	2	PPIfs	PPIfs	NNP
cord-001835-0s7ok4uw	4909	3	from	from	IN
cord-001835-0s7ok4uw	4909	4	a	a	DT
cord-001835-0s7ok4uw	4909	5	three	three	CD
cord-001835-0s7ok4uw	4909	6	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	4909	7	structure	structure	NN
cord-001835-0s7ok4uw	4909	8	is	be	VBZ
cord-001835-0s7ok4uw	4909	9	a	a	DT
cord-001835-0s7ok4uw	4909	10	key	key	JJ
cord-001835-0s7ok4uw	4909	11	task	task	NN
cord-001835-0s7ok4uw	4909	12	for	for	IN
cord-001835-0s7ok4uw	4909	13	the	the	DT
cord-001835-0s7ok4uw	4909	14	modulation	modulation	NN
cord-001835-0s7ok4uw	4909	15	of	of	IN
cord-001835-0s7ok4uw	4909	16	PPIs	ppi	NNS
cord-001835-0s7ok4uw	4909	17	.	.	.
cord-001835-0s7ok4uw	4910	1	The	the	DT
cord-001835-0s7ok4uw	4910	2	use	use	NN
cord-001835-0s7ok4uw	4910	3	of	of	IN
cord-001835-0s7ok4uw	4910	4	the	the	DT
cord-001835-0s7ok4uw	4910	5	NIP	nip	NN
cord-001835-0s7ok4uw	4910	6	-	-	HYPH
cord-001835-0s7ok4uw	4910	7	based	base	VBN
cord-001835-0s7ok4uw	4910	8	hotspots	hotspot	NNS
cord-001835-0s7ok4uw	4910	9	prediction	prediction	NN
cord-001835-0s7ok4uw	4910	10	method	method	NN
cord-001835-0s7ok4uw	4910	11	improve	improve	VBP
cord-001835-0s7ok4uw	4910	12	the	the	DT
cord-001835-0s7ok4uw	4910	13	identification	identification	NN
cord-001835-0s7ok4uw	4910	14	of	of	IN
cord-001835-0s7ok4uw	4910	15	transient	transient	JJ
cord-001835-0s7ok4uw	4910	16	cavities	cavity	NNS
cord-001835-0s7ok4uw	4910	17	from	from	IN
cord-001835-0s7ok4uw	4910	18	MD	MD	NNP
cord-001835-0s7ok4uw	4910	19	simulation	simulation	NN
cord-001835-0s7ok4uw	4910	20	when	when	WRB
cord-001835-0s7ok4uw	4910	21	compared	compare	VBN
cord-001835-0s7ok4uw	4910	22	to	to	IN
cord-001835-0s7ok4uw	4910	23	known	know	VBN
cord-001835-0s7ok4uw	4910	24	binding	bind	VBG
cord-001835-0s7ok4uw	4910	25	cavities	cavity	NNS
cord-001835-0s7ok4uw	4910	26	.	.	.
cord-001835-0s7ok4uw	4911	1	This	this	DT
cord-001835-0s7ok4uw	4911	2	approach	approach	NN
cord-001835-0s7ok4uw	4911	3	can	can	MD
cord-001835-0s7ok4uw	4911	4	be	be	VB
cord-001835-0s7ok4uw	4911	5	extremely	extremely	RB
cord-001835-0s7ok4uw	4911	6	useful	useful	JJ
cord-001835-0s7ok4uw	4911	7	in	in	IN
cord-001835-0s7ok4uw	4911	8	a	a	DT
cord-001835-0s7ok4uw	4911	9	realistic	realistic	JJ
cord-001835-0s7ok4uw	4911	10	scenario	scenario	NN
cord-001835-0s7ok4uw	4911	11	of	of	IN
cord-001835-0s7ok4uw	4911	12	drug	drug	NN
cord-001835-0s7ok4uw	4911	13	discovery	discovery	NN
cord-001835-0s7ok4uw	4911	14	targeting	target	VBG
cord-001835-0s7ok4uw	4911	15	PPIfs	ppifs	PRP
cord-001835-0s7ok4uw	4911	16	,	,	,
cord-001835-0s7ok4uw	4911	17	when	when	WRB
cord-001835-0s7ok4uw	4911	18	there	there	EX
cord-001835-0s7ok4uw	4911	19	is	be	VBZ
cord-001835-0s7ok4uw	4911	20	no	no	DT
cord-001835-0s7ok4uw	4911	21	information	information	NN
cord-001835-0s7ok4uw	4911	22	at	at	RB
cord-001835-0s7ok4uw	4911	23	all	all	RB
cord-001835-0s7ok4uw	4911	24	about	about	IN
cord-001835-0s7ok4uw	4911	25	the	the	DT
cord-001835-0s7ok4uw	4911	26	protein	protein	NN
cord-001835-0s7ok4uw	4911	27	-	-	HYPH
cord-001835-0s7ok4uw	4911	28	protein	protein	NN
cord-001835-0s7ok4uw	4911	29	complex	complex	JJ
cord-001835-0s7ok4uw	4911	30	structure	structure	NN
cord-001835-0s7ok4uw	4911	31	.	.	.
cord-001835-0s7ok4uw	4912	1	Protein	protein	NN
cord-001835-0s7ok4uw	4912	2	complexes	complex	NNS
cord-001835-0s7ok4uw	4912	3	are	be	VBP
cord-001835-0s7ok4uw	4912	4	the	the	DT
cord-001835-0s7ok4uw	4912	5	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	4912	6	molecular	molecular	JJ
cord-001835-0s7ok4uw	4912	7	organizations	organization	NNS
cord-001835-0s7ok4uw	4912	8	that	that	WDT
cord-001835-0s7ok4uw	4912	9	assemble	assemble	VBP
cord-001835-0s7ok4uw	4912	10	multiple	multiple	JJ
cord-001835-0s7ok4uw	4912	11	proteins	protein	NNS
cord-001835-0s7ok4uw	4912	12	to	to	TO
cord-001835-0s7ok4uw	4912	13	achieve	achieve	VB
cord-001835-0s7ok4uw	4912	14	various	various	JJ
cord-001835-0s7ok4uw	4912	15	biological	biological	JJ
cord-001835-0s7ok4uw	4912	16	processes	process	NNS
cord-001835-0s7ok4uw	4912	17	.	.	.
cord-001835-0s7ok4uw	4913	1	Identification	identification	NN
cord-001835-0s7ok4uw	4913	2	of	of	IN
cord-001835-0s7ok4uw	4913	3	protein	protein	NN
cord-001835-0s7ok4uw	4913	4	complex	complex	JJ
cord-001835-0s7ok4uw	4913	5	membership	membership	NN
cord-001835-0s7ok4uw	4913	6	should	should	MD
cord-001835-0s7ok4uw	4913	7	provide	provide	VB
cord-001835-0s7ok4uw	4913	8	a	a	DT
cord-001835-0s7ok4uw	4913	9	genotype	genotype	NN
cord-001835-0s7ok4uw	4913	10	-	-	HYPH
cord-001835-0s7ok4uw	4913	11	phenotype	phenotype	NN
cord-001835-0s7ok4uw	4913	12	map	map	NN
cord-001835-0s7ok4uw	4913	13	to	to	TO
cord-001835-0s7ok4uw	4913	14	elucidate	elucidate	VB
cord-001835-0s7ok4uw	4913	15	human	human	JJ
cord-001835-0s7ok4uw	4913	16	gene	gene	NN
cord-001835-0s7ok4uw	4913	17	-	-	HYPH
cord-001835-0s7ok4uw	4913	18	disease	disease	NN
cord-001835-0s7ok4uw	4913	19	associations	association	NNS
cord-001835-0s7ok4uw	4913	20	.	.	.
cord-001835-0s7ok4uw	4914	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4914	2	has	have	VBZ
cord-001835-0s7ok4uw	4914	3	been	be	VBN
cord-001835-0s7ok4uw	4914	4	routinely	routinely	RB
cord-001835-0s7ok4uw	4914	5	assumed	assume	VBN
cord-001835-0s7ok4uw	4914	6	that	that	IN
cord-001835-0s7ok4uw	4914	7	network	network	NN
cord-001835-0s7ok4uw	4914	8	clusters	cluster	NNS
cord-001835-0s7ok4uw	4914	9	with	with	IN
cord-001835-0s7ok4uw	4914	10	dense	dense	JJ
cord-001835-0s7ok4uw	4914	11	connections	connection	NNS
cord-001835-0s7ok4uw	4914	12	inside	inside	IN
cord-001835-0s7ok4uw	4914	13	and	and	CC
cord-001835-0s7ok4uw	4914	14	sparse	sparse	JJ
cord-001835-0s7ok4uw	4914	15	connections	connection	NNS
cord-001835-0s7ok4uw	4914	16	outside	outside	RB
cord-001835-0s7ok4uw	4914	17	would	would	MD
cord-001835-0s7ok4uw	4914	18	form	form	VB
cord-001835-0s7ok4uw	4914	19	functional	functional	JJ
cord-001835-0s7ok4uw	4914	20	protein	protein	NN
cord-001835-0s7ok4uw	4914	21	complexes	complex	NNS
cord-001835-0s7ok4uw	4914	22	.	.	.
cord-001835-0s7ok4uw	4915	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	4915	2	,	,	,
cord-001835-0s7ok4uw	4915	3	searching	search	VBG
cord-001835-0s7ok4uw	4915	4	highly	highly	RB
cord-001835-0s7ok4uw	4915	5	modular	modular	JJ
cord-001835-0s7ok4uw	4915	6	subgraphs	subgraphs	NN
cord-001835-0s7ok4uw	4915	7	in	in	IN
cord-001835-0s7ok4uw	4915	8	protein	protein	NN
cord-001835-0s7ok4uw	4915	9	-	-	HYPH
cord-001835-0s7ok4uw	4915	10	protein	protein	NN
cord-001835-0s7ok4uw	4915	11	interaction	interaction	NN
cord-001835-0s7ok4uw	4915	12	networks	network	NNS
cord-001835-0s7ok4uw	4915	13	was	be	VBD
cord-001835-0s7ok4uw	4915	14	explicitly	explicitly	RB
cord-001835-0s7ok4uw	4915	15	or	or	CC
cord-001835-0s7ok4uw	4915	16	implicitly	implicitly	RB
cord-001835-0s7ok4uw	4915	17	implemented	implement	VBN
cord-001835-0s7ok4uw	4915	18	in	in	IN
cord-001835-0s7ok4uw	4915	19	the	the	DT
cord-001835-0s7ok4uw	4915	20	algorithms	algorithm	NNS
cord-001835-0s7ok4uw	4915	21	to	to	TO
cord-001835-0s7ok4uw	4915	22	find	find	VB
cord-001835-0s7ok4uw	4915	23	protein	protein	NN
cord-001835-0s7ok4uw	4915	24	complexes	complex	NNS
cord-001835-0s7ok4uw	4915	25	.	.	.
cord-001835-0s7ok4uw	4916	1	However	however	RB
cord-001835-0s7ok4uw	4916	2	,	,	,
cord-001835-0s7ok4uw	4916	3	to	to	IN
cord-001835-0s7ok4uw	4916	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4916	5	surprise	surprise	NN
cord-001835-0s7ok4uw	4916	6	,	,	,
cord-001835-0s7ok4uw	4916	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	4916	8	found	find	VBD
cord-001835-0s7ok4uw	4916	9	a	a	DT
cord-001835-0s7ok4uw	4916	10	large	large	JJ
cord-001835-0s7ok4uw	4916	11	portion	portion	NN
cord-001835-0s7ok4uw	4916	12	of	of	IN
cord-001835-0s7ok4uw	4916	13	complexes	complex	NNS
cord-001835-0s7ok4uw	4916	14	with	with	IN
cord-001835-0s7ok4uw	4916	15	a	a	DT
cord-001835-0s7ok4uw	4916	16	medium	medium	NN
cord-001835-0s7ok4uw	4916	17	-	-	HYPH
cord-001835-0s7ok4uw	4916	18	to	to	IN
cord-001835-0s7ok4uw	4916	19	-	-	HYPH
cord-001835-0s7ok4uw	4916	20	low	low	JJ
cord-001835-0s7ok4uw	4916	21	modularity	modularity	NN
cord-001835-0s7ok4uw	4916	22	from	from	IN
cord-001835-0s7ok4uw	4916	23	the	the	DT
cord-001835-0s7ok4uw	4916	24	analysis	analysis	NN
cord-001835-0s7ok4uw	4916	25	of	of	IN
cord-001835-0s7ok4uw	4916	26	719	719	CD
cord-001835-0s7ok4uw	4916	27	experimentally	experimentally	RB
cord-001835-0s7ok4uw	4916	28	confirmed	confirm	VBN
cord-001835-0s7ok4uw	4916	29	protein	protein	NN
cord-001835-0s7ok4uw	4916	30	complexes	complex	NNS
cord-001835-0s7ok4uw	4916	31	.	.	.
cord-001835-0s7ok4uw	4917	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4917	2	also	also	RB
cord-001835-0s7ok4uw	4917	3	discovered	discover	VBD
cord-001835-0s7ok4uw	4917	4	that	that	IN
cord-001835-0s7ok4uw	4917	5	these	these	DT
cord-001835-0s7ok4uw	4917	6	complexes	complex	NNS
cord-001835-0s7ok4uw	4917	7	have	have	VBP
cord-001835-0s7ok4uw	4917	8	cellular	cellular	JJ
cord-001835-0s7ok4uw	4917	9	functions	function	NNS
cord-001835-0s7ok4uw	4917	10	enriched	enrich	VBN
cord-001835-0s7ok4uw	4917	11	in	in	IN
cord-001835-0s7ok4uw	4917	12	highly	highly	JJ
cord-001835-0s7ok4uw	4917	13	time	time	NN
cord-001835-0s7ok4uw	4917	14	-	-	HYPH
cord-001835-0s7ok4uw	4917	15	and	and	CC
cord-001835-0s7ok4uw	4917	16	space	space	NN
cord-001835-0s7ok4uw	4917	17	-	-	HYPH
cord-001835-0s7ok4uw	4917	18	dependent	dependent	JJ
cord-001835-0s7ok4uw	4917	19	expression	expression	NN
cord-001835-0s7ok4uw	4917	20	,	,	,
cord-001835-0s7ok4uw	4917	21	such	such	JJ
cord-001835-0s7ok4uw	4917	22	as	as	IN
cord-001835-0s7ok4uw	4917	23	signal	signal	NN
cord-001835-0s7ok4uw	4917	24	transduction	transduction	NN
cord-001835-0s7ok4uw	4917	25	or	or	CC
cord-001835-0s7ok4uw	4917	26	subcellular	subcellular	JJ
cord-001835-0s7ok4uw	4917	27	localization	localization	NN
cord-001835-0s7ok4uw	4917	28	.	.	.
cord-001835-0s7ok4uw	4918	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4918	2	further	further	RB
cord-001835-0s7ok4uw	4918	3	developed	develop	VBD
cord-001835-0s7ok4uw	4918	4	an	an	DT
cord-001835-0s7ok4uw	4918	5	algorithm	algorithm	NN
cord-001835-0s7ok4uw	4918	6	to	to	TO
cord-001835-0s7ok4uw	4918	7	find	find	VB
cord-001835-0s7ok4uw	4918	8	such	such	JJ
cord-001835-0s7ok4uw	4918	9	complexes	complex	NNS
cord-001835-0s7ok4uw	4918	10	by	by	IN
cord-001835-0s7ok4uw	4918	11	weighing	weigh	VBG
cord-001835-0s7ok4uw	4918	12	network	network	NN
cord-001835-0s7ok4uw	4918	13	connections	connection	NNS
cord-001835-0s7ok4uw	4918	14	to	to	TO
cord-001835-0s7ok4uw	4918	15	capture	capture	VB
cord-001835-0s7ok4uw	4918	16	transient	transient	JJ
cord-001835-0s7ok4uw	4918	17	interactions	interaction	NNS
cord-001835-0s7ok4uw	4918	18	with	with	IN
cord-001835-0s7ok4uw	4918	19	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	4918	20	disordered	disordered	JJ
cord-001835-0s7ok4uw	4918	21	regions	region	NNS
cord-001835-0s7ok4uw	4918	22	.	.	.
cord-001835-0s7ok4uw	4919	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4919	2	confirmed	confirm	VBD
cord-001835-0s7ok4uw	4919	3	that	that	IN
cord-001835-0s7ok4uw	4919	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4919	5	method	method	NN
cord-001835-0s7ok4uw	4919	6	improved	improve	VBD
cord-001835-0s7ok4uw	4919	7	the	the	DT
cord-001835-0s7ok4uw	4919	8	identification	identification	NN
cord-001835-0s7ok4uw	4919	9	of	of	IN
cord-001835-0s7ok4uw	4919	10	biologically	biologically	RB
cord-001835-0s7ok4uw	4919	11	relevant	relevant	JJ
cord-001835-0s7ok4uw	4919	12	members	member	NNS
cord-001835-0s7ok4uw	4919	13	of	of	IN
cord-001835-0s7ok4uw	4919	14	protein	protein	NN
cord-001835-0s7ok4uw	4919	15	complexes	complex	NNS
cord-001835-0s7ok4uw	4919	16	and	and	CC
cord-001835-0s7ok4uw	4919	17	covered	cover	VBD
cord-001835-0s7ok4uw	4919	18	more	more	JJR
cord-001835-0s7ok4uw	4919	19	complexes	complex	NNS
cord-001835-0s7ok4uw	4919	20	with	with	IN
cord-001835-0s7ok4uw	4919	21	a	a	DT
cord-001835-0s7ok4uw	4919	22	medium	medium	NN
cord-001835-0s7ok4uw	4919	23	-	-	HYPH
cord-001835-0s7ok4uw	4919	24	to	to	IN
cord-001835-0s7ok4uw	4919	25	-	-	HYPH
cord-001835-0s7ok4uw	4919	26	low	low	JJ
cord-001835-0s7ok4uw	4919	27	modularity	modularity	NN
cord-001835-0s7ok4uw	4919	28	.	.	.
cord-001835-0s7ok4uw	4920	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	4920	2	,	,	,
cord-001835-0s7ok4uw	4920	3	newly	newly	RB
cord-001835-0s7ok4uw	4920	4	discovered	discover	VBN
cord-001835-0s7ok4uw	4920	5	subunits	subunit	NNS
cord-001835-0s7ok4uw	4920	6	in	in	IN
cord-001835-0s7ok4uw	4920	7	protein	protein	NN
cord-001835-0s7ok4uw	4920	8	complexes	complex	NNS
cord-001835-0s7ok4uw	4920	9	could	could	MD
cord-001835-0s7ok4uw	4920	10	explain	explain	VB
cord-001835-0s7ok4uw	4920	11	more	more	JJR
cord-001835-0s7ok4uw	4920	12	disease	disease	NN
cord-001835-0s7ok4uw	4920	13	-	-	HYPH
cord-001835-0s7ok4uw	4920	14	gene	gene	NN
cord-001835-0s7ok4uw	4920	15	associations	association	NNS
cord-001835-0s7ok4uw	4920	16	,	,	,
cord-001835-0s7ok4uw	4920	17	indicating	indicate	VBG
cord-001835-0s7ok4uw	4920	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4920	19	utility	utility	NN
cord-001835-0s7ok4uw	4920	20	to	to	TO
cord-001835-0s7ok4uw	4920	21	expand	expand	VB
cord-001835-0s7ok4uw	4920	22	current	current	JJ
cord-001835-0s7ok4uw	4920	23	genotype	genotype	NN
cord-001835-0s7ok4uw	4920	24	-	-	HYPH
cord-001835-0s7ok4uw	4920	25	phenotype	phenotype	NN
cord-001835-0s7ok4uw	4920	26	map	map	NN
cord-001835-0s7ok4uw	4920	27	of	of	IN
cord-001835-0s7ok4uw	4920	28	human	human	JJ
cord-001835-0s7ok4uw	4920	29	diseases	disease	NNS
cord-001835-0s7ok4uw	4920	30	.	.	.
cord-001835-0s7ok4uw	4921	1	Expanding	expand	VBG
cord-001835-0s7ok4uw	4921	2	template	template	NN
cord-001835-0s7ok4uw	4921	3	-	-	HYPH
cord-001835-0s7ok4uw	4921	4	based	base	VBN
cord-001835-0s7ok4uw	4921	5	protein	protein	NN
cord-001835-0s7ok4uw	4921	6	-	-	HYPH
cord-001835-0s7ok4uw	4921	7	protein	protein	NN
cord-001835-0s7ok4uw	4921	8	complex	complex	JJ
cord-001835-0s7ok4uw	4921	9	prediction	prediction	NN
cord-001835-0s7ok4uw	4921	10	using	use	VBG
cord-001835-0s7ok4uw	4921	11	ab	ab	JJ
cord-001835-0s7ok4uw	4921	12	-	-	HYPH
cord-001835-0s7ok4uw	4921	13	initio	initio	JJ
cord-001835-0s7ok4uw	4921	14	docking	docking	NN
cord-001835-0s7ok4uw	4921	15	Sergio	Sergio	NNP
cord-001835-0s7ok4uw	4921	16	Mares	Mares	NNPS
cord-001835-0s7ok4uw	4921	17	-	-	HYPH
cord-001835-0s7ok4uw	4921	18	S	S	NNP
cord-001835-0s7ok4uw	4921	19	amano	amano	NNP
cord-001835-0s7ok4uw	4921	20	1	1	CD
cord-001835-0s7ok4uw	4921	21	,	,	,
cord-001835-0s7ok4uw	4921	22	Luis	Luis	NNP
cord-001835-0s7ok4uw	4921	23	Angel	Angel	NNP
cord-001835-0s7ok4uw	4921	24	Rodr	Rodr	NNP
cord-001835-0s7ok4uw	4921	25	ıguez	ıguez	NNP
cord-001835-0s7ok4uw	4921	26	-	-	HYPH
cord-001835-0s7ok4uw	4921	27	Lumbreras	Lumbreras	NNP
cord-001835-0s7ok4uw	4921	28	1	1	CD
cord-001835-0s7ok4uw	4921	29	,	,	,
cord-001835-0s7ok4uw	4921	30	Juan	Juan	NNP
cord-001835-0s7ok4uw	4921	31	Fern	Fern	NNP
cord-001835-0s7ok4uw	4922	1	andez	andez	NNP
cord-001835-0s7ok4uw	4922	2	-	-	HYPH
cord-001835-0s7ok4uw	4922	3	Recio	Recio	NNP
cord-001835-0s7ok4uw	4922	4	1	1	CD
cord-001835-0s7ok4uw	4922	5	1	1	CD
cord-001835-0s7ok4uw	4922	6	Structural	structural	JJ
cord-001835-0s7ok4uw	4922	7	characterization	characterization	NN
cord-001835-0s7ok4uw	4922	8	of	of	IN
cord-001835-0s7ok4uw	4922	9	protein	protein	NN
cord-001835-0s7ok4uw	4922	10	-	-	HYPH
cord-001835-0s7ok4uw	4922	11	protein	protein	NN
cord-001835-0s7ok4uw	4922	12	interaction	interaction	NN
cord-001835-0s7ok4uw	4922	13	(	(	-LRB-
cord-001835-0s7ok4uw	4922	14	PPI	PPI	NNP
cord-001835-0s7ok4uw	4922	15	)	)	-RRB-
cord-001835-0s7ok4uw	4922	16	networks	network	NNS
cord-001835-0s7ok4uw	4922	17	is	be	VBZ
cord-001835-0s7ok4uw	4922	18	crucial	crucial	JJ
cord-001835-0s7ok4uw	4922	19	for	for	IN
cord-001835-0s7ok4uw	4922	20	understanding	understand	VBG
cord-001835-0s7ok4uw	4922	21	the	the	DT
cord-001835-0s7ok4uw	4922	22	underlying	underlie	VBG
cord-001835-0s7ok4uw	4922	23	molecular	molecular	JJ
cord-001835-0s7ok4uw	4922	24	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4922	25	whereby	whereby	WRB
cord-001835-0s7ok4uw	4922	26	life	life	NN
cord-001835-0s7ok4uw	4922	27	processes	process	NNS
cord-001835-0s7ok4uw	4922	28	and	and	CC
cord-001835-0s7ok4uw	4922	29	disease	disease	NN
cord-001835-0s7ok4uw	4922	30	arise	arise	VB
cord-001835-0s7ok4uw	4922	31	.	.	.
cord-001835-0s7ok4uw	4923	1	However	however	RB
cord-001835-0s7ok4uw	4923	2	,	,	,
cord-001835-0s7ok4uw	4923	3	due	due	IN
cord-001835-0s7ok4uw	4923	4	to	to	IN
cord-001835-0s7ok4uw	4923	5	inherent	inherent	JJ
cord-001835-0s7ok4uw	4923	6	limitations	limitation	NNS
cord-001835-0s7ok4uw	4923	7	of	of	IN
cord-001835-0s7ok4uw	4923	8	experimental	experimental	JJ
cord-001835-0s7ok4uw	4923	9	techniques	technique	NNS
cord-001835-0s7ok4uw	4923	10	,	,	,
cord-001835-0s7ok4uw	4923	11	such	such	JJ
cord-001835-0s7ok4uw	4923	12	characterization	characterization	NN
cord-001835-0s7ok4uw	4923	13	only	only	RB
cord-001835-0s7ok4uw	4923	14	covers	cover	VBZ
cord-001835-0s7ok4uw	4923	15	an	an	DT
cord-001835-0s7ok4uw	4923	16	extremely	extremely	RB
cord-001835-0s7ok4uw	4923	17	reduced	reduce	VBN
cord-001835-0s7ok4uw	4923	18	fraction	fraction	NN
cord-001835-0s7ok4uw	4923	19	of	of	IN
cord-001835-0s7ok4uw	4923	20	the	the	DT
cord-001835-0s7ok4uw	4923	21	human	human	JJ
cord-001835-0s7ok4uw	4923	22	PPI	PPI	NNP
cord-001835-0s7ok4uw	4923	23	network	network	NN
cord-001835-0s7ok4uw	4923	24	(	(	-LRB-
cord-001835-0s7ok4uw	4923	25	interactome	interactome	NNP
cord-001835-0s7ok4uw	4923	26	)	)	-RRB-
cord-001835-0s7ok4uw	4923	27	.	.	.
cord-001835-0s7ok4uw	4924	1	Recent	recent	JJ
cord-001835-0s7ok4uw	4924	2	studies	study	NNS
cord-001835-0s7ok4uw	4924	3	have	have	VBP
cord-001835-0s7ok4uw	4924	4	shown	show	VBN
cord-001835-0s7ok4uw	4924	5	that	that	IN
cord-001835-0s7ok4uw	4924	6	although	although	IN
cord-001835-0s7ok4uw	4924	7	available	available	JJ
cord-001835-0s7ok4uw	4924	8	structural	structural	JJ
cord-001835-0s7ok4uw	4924	9	templates	template	NNS
cord-001835-0s7ok4uw	4924	10	may	may	MD
cord-001835-0s7ok4uw	4924	11	suffice	suffice	VB
cord-001835-0s7ok4uw	4924	12	to	to	TO
cord-001835-0s7ok4uw	4924	13	model	model	VB
cord-001835-0s7ok4uw	4924	14	a	a	DT
cord-001835-0s7ok4uw	4924	15	significant	significant	JJ
cord-001835-0s7ok4uw	4924	16	proportion	proportion	NN
cord-001835-0s7ok4uw	4924	17	of	of	IN
cord-001835-0s7ok4uw	4924	18	the	the	DT
cord-001835-0s7ok4uw	4924	19	interactome	interactome	NN
cord-001835-0s7ok4uw	4924	20	,	,	,
cord-001835-0s7ok4uw	4924	21	model	model	NN
cord-001835-0s7ok4uw	4924	22	accuracy	accuracy	NN
cord-001835-0s7ok4uw	4924	23	and	and	CC
cord-001835-0s7ok4uw	4924	24	binding	bind	VBG
cord-001835-0s7ok4uw	4924	25	specificity	specificity	NN
cord-001835-0s7ok4uw	4924	26	remain	remain	VBP
cord-001835-0s7ok4uw	4924	27	unsolved	unsolved	JJ
cord-001835-0s7ok4uw	4924	28	problems	problem	NNS
cord-001835-0s7ok4uw	4924	29	.	.	.
cord-001835-0s7ok4uw	4925	1	Consequently	consequently	RB
cord-001835-0s7ok4uw	4925	2	,	,	,
cord-001835-0s7ok4uw	4925	3	improving	improve	VBG
cord-001835-0s7ok4uw	4925	4	the	the	DT
cord-001835-0s7ok4uw	4925	5	ability	ability	NN
cord-001835-0s7ok4uw	4925	6	to	to	TO
cord-001835-0s7ok4uw	4925	7	predict	predict	VB
cord-001835-0s7ok4uw	4925	8	PPIs	ppi	NNS
cord-001835-0s7ok4uw	4925	9	structurally	structurally	RB
cord-001835-0s7ok4uw	4925	10	will	will	MD
cord-001835-0s7ok4uw	4925	11	help	help	VB
cord-001835-0s7ok4uw	4925	12	to	to	TO
cord-001835-0s7ok4uw	4925	13	provide	provide	VB
cord-001835-0s7ok4uw	4925	14	a	a	DT
cord-001835-0s7ok4uw	4925	15	better	well	JJR
cord-001835-0s7ok4uw	4925	16	3D	3d	JJ
cord-001835-0s7ok4uw	4925	17	profile	profile	NN
cord-001835-0s7ok4uw	4925	18	of	of	IN
cord-001835-0s7ok4uw	4925	19	the	the	DT
cord-001835-0s7ok4uw	4925	20	known	know	VBN
cord-001835-0s7ok4uw	4925	21	interactome	interactome	NNP
cord-001835-0s7ok4uw	4925	22	,	,	,
cord-001835-0s7ok4uw	4925	23	which	which	WDT
cord-001835-0s7ok4uw	4925	24	may	may	MD
cord-001835-0s7ok4uw	4925	25	ultimately	ultimately	RB
cord-001835-0s7ok4uw	4925	26	lead	lead	VB
cord-001835-0s7ok4uw	4925	27	to	to	IN
cord-001835-0s7ok4uw	4925	28	the	the	DT
cord-001835-0s7ok4uw	4925	29	development	development	NN
cord-001835-0s7ok4uw	4925	30	of	of	IN
cord-001835-0s7ok4uw	4925	31	new	new	JJ
cord-001835-0s7ok4uw	4925	32	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	4925	33	applications	application	NNS
cord-001835-0s7ok4uw	4925	34	.	.	.
cord-001835-0s7ok4uw	4926	1	Here	here	RB
cord-001835-0s7ok4uw	4926	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	4926	3	show	show	VBP
cord-001835-0s7ok4uw	4926	4	a	a	DT
cord-001835-0s7ok4uw	4926	5	novel	novel	JJ
cord-001835-0s7ok4uw	4926	6	approach	approach	NN
cord-001835-0s7ok4uw	4926	7	that	that	WDT
cord-001835-0s7ok4uw	4926	8	combines	combine	VBZ
cord-001835-0s7ok4uw	4926	9	templatebased	templatebased	JJ
cord-001835-0s7ok4uw	4926	10	modeling	modeling	NN
cord-001835-0s7ok4uw	4926	11	with	with	IN
cord-001835-0s7ok4uw	4926	12	protein	protein	NN
cord-001835-0s7ok4uw	4926	13	-	-	HYPH
cord-001835-0s7ok4uw	4926	14	protein	protein	NN
cord-001835-0s7ok4uw	4926	15	computational	computational	JJ
cord-001835-0s7ok4uw	4926	16	docking	docking	NN
cord-001835-0s7ok4uw	4926	17	to	to	IN
cord-001835-0s7ok4uw	4926	18	the	the	DT
cord-001835-0s7ok4uw	4926	19	structure	structure	NN
cord-001835-0s7ok4uw	4926	20	-	-	HYPH
cord-001835-0s7ok4uw	4926	21	based	base	VBN
cord-001835-0s7ok4uw	4926	22	prediction	prediction	NN
cord-001835-0s7ok4uw	4926	23	of	of	IN
cord-001835-0s7ok4uw	4926	24	PPIs	ppi	NNS
cord-001835-0s7ok4uw	4926	25	.	.	.
cord-001835-0s7ok4uw	4927	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4927	2	approach	approach	NN
cord-001835-0s7ok4uw	4927	3	samples	sample	VBZ
cord-001835-0s7ok4uw	4927	4	different	different	JJ
cord-001835-0s7ok4uw	4927	5	protein	protein	NN
cord-001835-0s7ok4uw	4927	6	-	-	HYPH
cord-001835-0s7ok4uw	4927	7	protein	protein	NN
cord-001835-0s7ok4uw	4927	8	structural	structural	JJ
cord-001835-0s7ok4uw	4927	9	models	model	NNS
cord-001835-0s7ok4uw	4927	10	derived	derive	VBN
cord-001835-0s7ok4uw	4927	11	from	from	IN
cord-001835-0s7ok4uw	4927	12	docking	docking	NN
cord-001835-0s7ok4uw	4927	13	simulations	simulation	NNS
cord-001835-0s7ok4uw	4927	14	.	.	.
cord-001835-0s7ok4uw	4928	1	Models	model	NNS
cord-001835-0s7ok4uw	4928	2	are	be	VBP
cord-001835-0s7ok4uw	4928	3	subsequently	subsequently	RB
cord-001835-0s7ok4uw	4928	4	ranked	rank	VBN
cord-001835-0s7ok4uw	4928	5	using	use	VBG
cord-001835-0s7ok4uw	4928	6	a	a	DT
cord-001835-0s7ok4uw	4928	7	function	function	NN
cord-001835-0s7ok4uw	4928	8	that	that	WDT
cord-001835-0s7ok4uw	4928	9	incorporates	incorporate	VBZ
cord-001835-0s7ok4uw	4928	10	an	an	DT
cord-001835-0s7ok4uw	4928	11	energy	energy	NN
cord-001835-0s7ok4uw	4928	12	-	-	HYPH
cord-001835-0s7ok4uw	4928	13	based	base	VBN
cord-001835-0s7ok4uw	4928	14	scoring	scoring	NN
cord-001835-0s7ok4uw	4928	15	term	term	NN
cord-001835-0s7ok4uw	4928	16	and	and	CC
cord-001835-0s7ok4uw	4928	17	a	a	DT
cord-001835-0s7ok4uw	4928	18	structural	structural	JJ
cord-001835-0s7ok4uw	4928	19	template	template	NN
cord-001835-0s7ok4uw	4928	20	similarity	similarity	NN
cord-001835-0s7ok4uw	4928	21	score	score	NN
cord-001835-0s7ok4uw	4928	22	.	.	.
cord-001835-0s7ok4uw	4929	1	The	the	DT
cord-001835-0s7ok4uw	4929	2	energy	energy	NN
cord-001835-0s7ok4uw	4929	3	-	-	HYPH
cord-001835-0s7ok4uw	4929	4	based	base	VBN
cord-001835-0s7ok4uw	4929	5	scoring	scoring	NN
cord-001835-0s7ok4uw	4929	6	function	function	NN
cord-001835-0s7ok4uw	4929	7	includes	include	VBZ
cord-001835-0s7ok4uw	4929	8	electrostatics	electrostatic	NNS
cord-001835-0s7ok4uw	4929	9	,	,	,
cord-001835-0s7ok4uw	4929	10	van	van	NNP
cord-001835-0s7ok4uw	4929	11	de	de	NNP
cord-001835-0s7ok4uw	4929	12	Waals	Waals	NNP
cord-001835-0s7ok4uw	4929	13	and	and	CC
cord-001835-0s7ok4uw	4929	14	desolvation	desolvation	NN
cord-001835-0s7ok4uw	4929	15	calculations	calculation	NNS
cord-001835-0s7ok4uw	4929	16	,	,	,
cord-001835-0s7ok4uw	4929	17	whilst	whilst	IN
cord-001835-0s7ok4uw	4929	18	the	the	DT
cord-001835-0s7ok4uw	4929	19	template	template	NN
cord-001835-0s7ok4uw	4929	20	similarity	similarity	NN
cord-001835-0s7ok4uw	4929	21	score	score	NN
cord-001835-0s7ok4uw	4929	22	accounts	account	VBZ
cord-001835-0s7ok4uw	4929	23	for	for	IN
cord-001835-0s7ok4uw	4929	24	the	the	DT
cord-001835-0s7ok4uw	4929	25	degree	degree	NN
cord-001835-0s7ok4uw	4929	26	of	of	IN
cord-001835-0s7ok4uw	4929	27	structural	structural	JJ
cord-001835-0s7ok4uw	4929	28	similarity	similarity	NN
cord-001835-0s7ok4uw	4929	29	of	of	IN
cord-001835-0s7ok4uw	4929	30	models	model	NNS
cord-001835-0s7ok4uw	4929	31	against	against	IN
cord-001835-0s7ok4uw	4929	32	a	a	DT
cord-001835-0s7ok4uw	4929	33	high	high	JJ
cord-001835-0s7ok4uw	4929	34	-	-	HYPH
cord-001835-0s7ok4uw	4929	35	resolution	resolution	NN
cord-001835-0s7ok4uw	4929	36	and	and	CC
cord-001835-0s7ok4uw	4929	37	diverse	diverse	JJ
cord-001835-0s7ok4uw	4929	38	dataset	dataset	NN
cord-001835-0s7ok4uw	4929	39	of	of	IN
cord-001835-0s7ok4uw	4929	40	structural	structural	JJ
cord-001835-0s7ok4uw	4929	41	templates	template	NNS
cord-001835-0s7ok4uw	4929	42	.	.	.
cord-001835-0s7ok4uw	4930	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	4930	2	approach	approach	NN
cord-001835-0s7ok4uw	4930	3	highly	highly	RB
cord-001835-0s7ok4uw	4930	4	improved	improve	VBD
cord-001835-0s7ok4uw	4930	5	the	the	DT
cord-001835-0s7ok4uw	4930	6	predictive	predictive	JJ
cord-001835-0s7ok4uw	4930	7	success	success	NN
cord-001835-0s7ok4uw	4930	8	rate	rate	NN
cord-001835-0s7ok4uw	4930	9	over	over	IN
cord-001835-0s7ok4uw	4930	10	individual	individual	JJ
cord-001835-0s7ok4uw	4930	11	ab	ab	JJ
cord-001835-0s7ok4uw	4930	12	-	-	HYPH
cord-001835-0s7ok4uw	4930	13	initio	initio	JJ
cord-001835-0s7ok4uw	4930	14	docking	docking	NN
cord-001835-0s7ok4uw	4930	15	and	and	CC
cord-001835-0s7ok4uw	4930	16	templatebased	templatebased	JJ
cord-001835-0s7ok4uw	4930	17	techniques	technique	NNS
cord-001835-0s7ok4uw	4930	18	across	across	IN
cord-001835-0s7ok4uw	4930	19	a	a	DT
cord-001835-0s7ok4uw	4930	20	large	large	JJ
cord-001835-0s7ok4uw	4930	21	benchmark	benchmark	NN
cord-001835-0s7ok4uw	4930	22	dataset	dataset	NN
cord-001835-0s7ok4uw	4930	23	,	,	,
cord-001835-0s7ok4uw	4930	24	including	include	VBG
cord-001835-0s7ok4uw	4930	25	176	176	CD
cord-001835-0s7ok4uw	4930	26	protein	protein	NN
cord-001835-0s7ok4uw	4930	27	-	-	HYPH
cord-001835-0s7ok4uw	4930	28	protein	protein	NN
cord-001835-0s7ok4uw	4930	29	complexes	complex	NNS
cord-001835-0s7ok4uw	4930	30	.	.	.
cord-001835-0s7ok4uw	4931	1	When	when	WRB
cord-001835-0s7ok4uw	4931	2	compared	compare	VBN
cord-001835-0s7ok4uw	4931	3	to	to	IN
cord-001835-0s7ok4uw	4931	4	the	the	DT
cord-001835-0s7ok4uw	4931	5	performance	performance	NN
cord-001835-0s7ok4uw	4931	6	of	of	IN
cord-001835-0s7ok4uw	4931	7	the	the	DT
cord-001835-0s7ok4uw	4931	8	ab	ab	JJ
cord-001835-0s7ok4uw	4931	9	-	-	HYPH
cord-001835-0s7ok4uw	4931	10	initio	initio	JJ
cord-001835-0s7ok4uw	4931	11	docking	docking	NN
cord-001835-0s7ok4uw	4931	12	algorithm	algorithm	NN
cord-001835-0s7ok4uw	4931	13	,	,	,
cord-001835-0s7ok4uw	4931	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	4931	15	found	find	VBD
cord-001835-0s7ok4uw	4931	16	that	that	IN
cord-001835-0s7ok4uw	4931	17	the	the	DT
cord-001835-0s7ok4uw	4931	18	approach	approach	NN
cord-001835-0s7ok4uw	4931	19	increased	increase	VBD
cord-001835-0s7ok4uw	4931	20	consistently	consistently	RB
cord-001835-0s7ok4uw	4931	21	the	the	DT
cord-001835-0s7ok4uw	4931	22	success	success	NN
cord-001835-0s7ok4uw	4931	23	rate	rate	NN
cord-001835-0s7ok4uw	4931	24	,	,	,
cord-001835-0s7ok4uw	4931	25	by	by	IN
cord-001835-0s7ok4uw	4931	26	approximately	approximately	RB
cord-001835-0s7ok4uw	4931	27	30	30	CD
cord-001835-0s7ok4uw	4931	28	%	%	NN
cord-001835-0s7ok4uw	4931	29	,	,	,
cord-001835-0s7ok4uw	4931	30	for	for	IN
cord-001835-0s7ok4uw	4931	31	the	the	DT
cord-001835-0s7ok4uw	4931	32	top	top	JJ
cord-001835-0s7ok4uw	4931	33	1	1	CD
cord-001835-0s7ok4uw	4931	34	,	,	,
cord-001835-0s7ok4uw	4931	35	top	top	JJ
cord-001835-0s7ok4uw	4931	36	5	5	CD
cord-001835-0s7ok4uw	4931	37	and	and	CC
cord-001835-0s7ok4uw	4931	38	top	top	JJ
cord-001835-0s7ok4uw	4931	39	10	10	CD
cord-001835-0s7ok4uw	4931	40	solutions	solution	NNS
cord-001835-0s7ok4uw	4931	41	.	.	.
cord-001835-0s7ok4uw	4932	1	The	the	DT
cord-001835-0s7ok4uw	4932	2	success	success	NN
cord-001835-0s7ok4uw	4932	3	rate	rate	NN
cord-001835-0s7ok4uw	4932	4	improvement	improvement	NN
cord-001835-0s7ok4uw	4932	5	was	be	VBD
cord-001835-0s7ok4uw	4932	6	even	even	RB
cord-001835-0s7ok4uw	4932	7	more	more	RBR
cord-001835-0s7ok4uw	4932	8	notorious	notorious	JJ
cord-001835-0s7ok4uw	4932	9	when	when	WRB
cord-001835-0s7ok4uw	4932	10	the	the	DT
cord-001835-0s7ok4uw	4932	11	comparison	comparison	NN
cord-001835-0s7ok4uw	4932	12	was	be	VBD
cord-001835-0s7ok4uw	4932	13	performed	perform	VBN
cord-001835-0s7ok4uw	4932	14	against	against	IN
cord-001835-0s7ok4uw	4932	15	the	the	DT
cord-001835-0s7ok4uw	4932	16	predictions	prediction	NNS
cord-001835-0s7ok4uw	4932	17	from	from	IN
cord-001835-0s7ok4uw	4932	18	the	the	DT
cord-001835-0s7ok4uw	4932	19	traditional	traditional	JJ
cord-001835-0s7ok4uw	4932	20	template	template	NN
cord-001835-0s7ok4uw	4932	21	-	-	HYPH
cord-001835-0s7ok4uw	4932	22	based	base	VBN
cord-001835-0s7ok4uw	4932	23	docking	docking	NN
cord-001835-0s7ok4uw	4932	24	.	.	.
cord-001835-0s7ok4uw	4933	1	Though	though	IN
cord-001835-0s7ok4uw	4933	2	incorporating	incorporate	VBG
cord-001835-0s7ok4uw	4933	3	ab	ab	JJ
cord-001835-0s7ok4uw	4933	4	-	-	HYPH
cord-001835-0s7ok4uw	4933	5	initio	initio	JJ
cord-001835-0s7ok4uw	4933	6	docking	docking	NN
cord-001835-0s7ok4uw	4933	7	expands	expand	VBZ
cord-001835-0s7ok4uw	4933	8	considerably	considerably	RB
cord-001835-0s7ok4uw	4933	9	the	the	DT
cord-001835-0s7ok4uw	4933	10	scope	scope	NN
cord-001835-0s7ok4uw	4933	11	of	of	IN
cord-001835-0s7ok4uw	4933	12	the	the	DT
cord-001835-0s7ok4uw	4933	13	template	template	NN
cord-001835-0s7ok4uw	4933	14	-	-	HYPH
cord-001835-0s7ok4uw	4933	15	based	base	VBN
cord-001835-0s7ok4uw	4933	16	docking	docking	NN
cord-001835-0s7ok4uw	4933	17	method	method	NN
cord-001835-0s7ok4uw	4933	18	,	,	,
cord-001835-0s7ok4uw	4933	19	challenges	challenge	NNS
cord-001835-0s7ok4uw	4933	20	remain	remain	VBP
cord-001835-0s7ok4uw	4933	21	for	for	IN
cord-001835-0s7ok4uw	4933	22	interacting	interact	VBG
cord-001835-0s7ok4uw	4933	23	proteins	protein	NNS
cord-001835-0s7ok4uw	4933	24	in	in	IN
cord-001835-0s7ok4uw	4933	25	which	which	WDT
cord-001835-0s7ok4uw	4933	26	high	high	JJ
cord-001835-0s7ok4uw	4933	27	conformational	conformational	JJ
cord-001835-0s7ok4uw	4933	28	changes	change	NNS
cord-001835-0s7ok4uw	4933	29	occur	occur	VBP
cord-001835-0s7ok4uw	4933	30	upon	upon	IN
cord-001835-0s7ok4uw	4933	31	binding	bind	VBG
cord-001835-0s7ok4uw	4933	32	and	and	CC
cord-001835-0s7ok4uw	4933	33	also	also	RB
cord-001835-0s7ok4uw	4933	34	the	the	DT
cord-001835-0s7ok4uw	4933	35	size	size	NN
cord-001835-0s7ok4uw	4933	36	and	and	CC
cord-001835-0s7ok4uw	4933	37	diversity	diversity	NN
cord-001835-0s7ok4uw	4933	38	of	of	IN
cord-001835-0s7ok4uw	4933	39	the	the	DT
cord-001835-0s7ok4uw	4933	40	repertoire	repertoire	NN
cord-001835-0s7ok4uw	4933	41	of	of	IN
cord-001835-0s7ok4uw	4933	42	structural	structural	JJ
cord-001835-0s7ok4uw	4933	43	templates	template	NNS
cord-001835-0s7ok4uw	4933	44	needs	need	VBZ
cord-001835-0s7ok4uw	4933	45	to	to	TO
cord-001835-0s7ok4uw	4933	46	be	be	VB
cord-001835-0s7ok4uw	4933	47	increased	increase	VBN
cord-001835-0s7ok4uw	4933	48	.	.	.
cord-001835-0s7ok4uw	4934	1	is	be	VBZ
cord-001835-0s7ok4uw	4934	2	essential	essential	JJ
cord-001835-0s7ok4uw	4934	3	for	for	IN
cord-001835-0s7ok4uw	4934	4	the	the	DT
cord-001835-0s7ok4uw	4934	5	development	development	NN
cord-001835-0s7ok4uw	4934	6	of	of	IN
cord-001835-0s7ok4uw	4934	7	multicellular	multicellular	JJ
cord-001835-0s7ok4uw	4934	8	organisms	organism	NNS
cord-001835-0s7ok4uw	4934	9	.	.	.
cord-001835-0s7ok4uw	4935	1	In	in	IN
cord-001835-0s7ok4uw	4935	2	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	4935	3	cells	cell	NNS
cord-001835-0s7ok4uw	4935	4	,	,	,
cord-001835-0s7ok4uw	4935	5	early	early	JJ
cord-001835-0s7ok4uw	4935	6	events	event	NNS
cord-001835-0s7ok4uw	4935	7	in	in	IN
cord-001835-0s7ok4uw	4935	8	PCD	PCD	NNP
cord-001835-0s7ok4uw	4935	9	involve	involve	VBP
cord-001835-0s7ok4uw	4935	10	the	the	DT
cord-001835-0s7ok4uw	4935	11	release	release	NN
cord-001835-0s7ok4uw	4935	12	of	of	IN
cord-001835-0s7ok4uw	4935	13	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	4935	14	c	c	NN
cord-001835-0s7ok4uw	4935	15	(	(	-LRB-
cord-001835-0s7ok4uw	4935	16	Cc	cc	NN
cord-001835-0s7ok4uw	4935	17	)	)	-RRB-
cord-001835-0s7ok4uw	4935	18	from	from	IN
cord-001835-0s7ok4uw	4935	19	mitochondria	mitochondrion	NNS
cord-001835-0s7ok4uw	4935	20	to	to	IN
cord-001835-0s7ok4uw	4935	21	the	the	DT
cord-001835-0s7ok4uw	4935	22	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	4935	23	,	,	,
cord-001835-0s7ok4uw	4935	24	so	so	RB
cord-001835-0s7ok4uw	4935	25	letting	let	VBG
cord-001835-0s7ok4uw	4935	26	Cc	Cc	NNP
cord-001835-0s7ok4uw	4935	27	play	play	VB
cord-001835-0s7ok4uw	4935	28	a	a	DT
cord-001835-0s7ok4uw	4935	29	key	key	JJ
cord-001835-0s7ok4uw	4935	30	role	role	NN
cord-001835-0s7ok4uw	4935	31	in	in	IN
cord-001835-0s7ok4uw	4935	32	assembling	assemble	VBG
cord-001835-0s7ok4uw	4935	33	the	the	DT
cord-001835-0s7ok4uw	4935	34	apoptosome	apoptosome	NN
cord-001835-0s7ok4uw	4935	35	and	and	CC
cord-001835-0s7ok4uw	4935	36	triggering	trigger	VBG
cord-001835-0s7ok4uw	4935	37	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	4935	38	.	.	.
cord-001835-0s7ok4uw	4936	1	In	in	IN
cord-001835-0s7ok4uw	4936	2	plants	plant	NNS
cord-001835-0s7ok4uw	4936	3	,	,	,
cord-001835-0s7ok4uw	4936	4	PCD	PCD	NNP
cord-001835-0s7ok4uw	4936	5	is	be	VBZ
cord-001835-0s7ok4uw	4936	6	part	part	NN
cord-001835-0s7ok4uw	4936	7	of	of	IN
cord-001835-0s7ok4uw	4936	8	a	a	DT
cord-001835-0s7ok4uw	4936	9	general	general	JJ
cord-001835-0s7ok4uw	4936	10	process	process	NN
cord-001835-0s7ok4uw	4937	1	-the	-the	NFP
cord-001835-0s7ok4uw	4937	2	so	so	RB
cord-001835-0s7ok4uw	4937	3	-	-	HYPH
cord-001835-0s7ok4uw	4937	4	called	call	VBN
cord-001835-0s7ok4uw	4937	5	hypersensitive	hypersensitive	JJ
cord-001835-0s7ok4uw	4937	6	response	response	NN
cord-001835-0s7ok4uw	4937	7	-in	-in	:
cord-001835-0s7ok4uw	4937	8	which	which	WDT
cord-001835-0s7ok4uw	4937	9	mitochondrial	mitochondrial	NN
cord-001835-0s7ok4uw	4937	10	Cc	Cc	NNP
cord-001835-0s7ok4uw	4937	11	is	be	VBZ
cord-001835-0s7ok4uw	4937	12	likewise	likewise	RB
cord-001835-0s7ok4uw	4937	13	released	release	VBN
cord-001835-0s7ok4uw	4937	14	into	into	IN
cord-001835-0s7ok4uw	4937	15	the	the	DT
cord-001835-0s7ok4uw	4937	16	cytosol	cytosol	NN
cord-001835-0s7ok4uw	4937	17	but	but	CC
cord-001835-0s7ok4uw	4937	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4937	19	further	further	JJ
cord-001835-0s7ok4uw	4937	20	role	role	NN
cord-001835-0s7ok4uw	4937	21	and	and	CC
cord-001835-0s7ok4uw	4937	22	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	4937	23	partners	partner	NNS
cord-001835-0s7ok4uw	4937	24	remain	remain	VBP
cord-001835-0s7ok4uw	4937	25	veiled	veiled	JJ
cord-001835-0s7ok4uw	4937	26	.	.	.
cord-001835-0s7ok4uw	4938	1	Such	such	PDT
cord-001835-0s7ok4uw	4938	2	a	a	DT
cord-001835-0s7ok4uw	4938	3	coincidence	coincidence	NN
cord-001835-0s7ok4uw	4938	4	in	in	IN
cord-001835-0s7ok4uw	4938	5	Cc	Cc	NNP
cord-001835-0s7ok4uw	4938	6	release	release	NN
cord-001835-0s7ok4uw	4938	7	made	make	VBD
cord-001835-0s7ok4uw	4938	8	us	-PRON-	PRP
cord-001835-0s7ok4uw	4938	9	think	think	VB
cord-001835-0s7ok4uw	4938	10	of	of	IN
cord-001835-0s7ok4uw	4938	11	a	a	DT
cord-001835-0s7ok4uw	4938	12	common	common	JJ
cord-001835-0s7ok4uw	4938	13	link	link	NN
cord-001835-0s7ok4uw	4938	14	for	for	IN
cord-001835-0s7ok4uw	4938	15	PCD	PCD	NNP
cord-001835-0s7ok4uw	4938	16	in	in	IN
cord-001835-0s7ok4uw	4938	17	such	such	JJ
cord-001835-0s7ok4uw	4938	18	evolutionarily	evolutionarily	RB
cord-001835-0s7ok4uw	4938	19	distant	distant	JJ
cord-001835-0s7ok4uw	4938	20	species	specie	NNS
cord-001835-0s7ok4uw	4938	21	along	along	IN
cord-001835-0s7ok4uw	4938	22	evolution	evolution	NN
cord-001835-0s7ok4uw	4938	23	.	.	.
cord-001835-0s7ok4uw	4939	1	To	to	TO
cord-001835-0s7ok4uw	4939	2	go	go	VB
cord-001835-0s7ok4uw	4939	3	deeper	deeply	RBR
cord-001835-0s7ok4uw	4939	4	in	in	IN
cord-001835-0s7ok4uw	4939	5	understanding	understand	VBG
cord-001835-0s7ok4uw	4939	6	the	the	DT
cord-001835-0s7ok4uw	4939	7	PCD	PCD	NNP
cord-001835-0s7ok4uw	4939	8	-	-	HYPH
cord-001835-0s7ok4uw	4939	9	dependent	dependent	JJ
cord-001835-0s7ok4uw	4939	10	role	role	NN
cord-001835-0s7ok4uw	4939	11	of	of	IN
cord-001835-0s7ok4uw	4939	12	Cc	Cc	NNP
cord-001835-0s7ok4uw	4939	13	,	,	,
cord-001835-0s7ok4uw	4939	14	a	a	DT
cord-001835-0s7ok4uw	4939	15	proteomic	proteomic	JJ
cord-001835-0s7ok4uw	4939	16	approach	approach	NN
cord-001835-0s7ok4uw	4939	17	based	base	VBN
cord-001835-0s7ok4uw	4939	18	on	on	IN
cord-001835-0s7ok4uw	4939	19	affinity	affinity	NN
cord-001835-0s7ok4uw	4939	20	chromatography	chromatography	NN
cord-001835-0s7ok4uw	4939	21	with	with	IN
cord-001835-0s7ok4uw	4939	22	Cc	Cc	NNP
cord-001835-0s7ok4uw	4939	23	as	as	IN
cord-001835-0s7ok4uw	4939	24	bait	bait	NN
cord-001835-0s7ok4uw	4939	25	was	be	VBD
cord-001835-0s7ok4uw	4939	26	run	run	VBN
cord-001835-0s7ok4uw	4939	27	using	use	VBG
cord-001835-0s7ok4uw	4939	28	human	human	JJ
cord-001835-0s7ok4uw	4939	29	and	and	CC
cord-001835-0s7ok4uw	4939	30	plant	plant	NN
cord-001835-0s7ok4uw	4939	31	cell	cell	NN
cord-001835-0s7ok4uw	4939	32	extracts	extract	NNS
cord-001835-0s7ok4uw	4939	33	.	.	.
cord-001835-0s7ok4uw	4940	1	Upon	upon	IN
cord-001835-0s7ok4uw	4940	2	combining	combine	VBG
cord-001835-0s7ok4uw	4940	3	this	this	DT
cord-001835-0s7ok4uw	4940	4	approach	approach	NN
cord-001835-0s7ok4uw	4940	5	with	with	IN
cord-001835-0s7ok4uw	4940	6	Bimolecular	Bimolecular	NNP
cord-001835-0s7ok4uw	4940	7	Fluorescence	Fluorescence	NNP
cord-001835-0s7ok4uw	4940	8	Complementation	Complementation	NNP
cord-001835-0s7ok4uw	4940	9	(	(	-LRB-
cord-001835-0s7ok4uw	4940	10	BIFC	BIFC	NNP
cord-001835-0s7ok4uw	4940	11	)	)	-RRB-
cord-001835-0s7ok4uw	4940	12	,	,	,
cord-001835-0s7ok4uw	4940	13	a	a	DT
cord-001835-0s7ok4uw	4940	14	total	total	NN
cord-001835-0s7ok4uw	4940	15	of	of	IN
cord-001835-0s7ok4uw	4940	16	eight	eight	CD
cord-001835-0s7ok4uw	4940	17	and	and	CC
cord-001835-0s7ok4uw	4940	18	nine	nine	CD
cord-001835-0s7ok4uw	4940	19	unknown	unknown	JJ
cord-001835-0s7ok4uw	4940	20	proteins	protein	NNS
cord-001835-0s7ok4uw	4940	21	interacting	interact	VBG
cord-001835-0s7ok4uw	4940	22	with	with	IN
cord-001835-0s7ok4uw	4940	23	Cc	Cc	NNP
cord-001835-0s7ok4uw	4940	24	under	under	IN
cord-001835-0s7ok4uw	4940	25	PCD	PCD	NNP
cord-001835-0s7ok4uw	4940	26	conditions	condition	NNS
cord-001835-0s7ok4uw	4940	27	were	be	VBD
cord-001835-0s7ok4uw	4940	28	identified	identify	VBN
cord-001835-0s7ok4uw	4940	29	in	in	IN
cord-001835-0s7ok4uw	4940	30	human	human	NN
cord-001835-0s7ok4uw	4940	31	and	and	CC
cord-001835-0s7ok4uw	4940	32	plant	plant	NN
cord-001835-0s7ok4uw	4940	33	cells	cell	NNS
cord-001835-0s7ok4uw	4940	34	,	,	,
cord-001835-0s7ok4uw	4940	35	respectively	respectively	RB
cord-001835-0s7ok4uw	4940	36	[	[	-LRB-
cord-001835-0s7ok4uw	4940	37	1	1	CD
cord-001835-0s7ok4uw	4940	38	,	,	,
cord-001835-0s7ok4uw	4940	39	2	2	CD
cord-001835-0s7ok4uw	4940	40	]	]	-RRB-
cord-001835-0s7ok4uw	4940	41	.	.	.
cord-001835-0s7ok4uw	4941	1	Such	such	JJ
cord-001835-0s7ok4uw	4941	2	novel	novel	NN
cord-001835-0s7ok4uw	4941	3	Cc	cc	NN
cord-001835-0s7ok4uw	4941	4	-	-	HYPH
cord-001835-0s7ok4uw	4941	5	partners	partner	NNS
cord-001835-0s7ok4uw	4941	6	-which	-which	JJS
cord-001835-0s7ok4uw	4941	7	are	be	VBP
cord-001835-0s7ok4uw	4941	8	located	locate	VBN
cord-001835-0s7ok4uw	4941	9	in	in	IN
cord-001835-0s7ok4uw	4941	10	the	the	DT
cord-001835-0s7ok4uw	4941	11	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	4941	12	and	and	CC
cord-001835-0s7ok4uw	4941	13	even	even	RB
cord-001835-0s7ok4uw	4941	14	in	in	IN
cord-001835-0s7ok4uw	4941	15	the	the	DT
cord-001835-0s7ok4uw	4941	16	nucleus	nucleus	NN
cord-001835-0s7ok4uw	4941	17	-are	-are	:
cord-001835-0s7ok4uw	4941	18	involved	involve	VBN
cord-001835-0s7ok4uw	4941	19	in	in	IN
cord-001835-0s7ok4uw	4941	20	protein	protein	NN
cord-001835-0s7ok4uw	4941	21	folding	folding	NN
cord-001835-0s7ok4uw	4941	22	,	,	,
cord-001835-0s7ok4uw	4941	23	translational	translational	JJ
cord-001835-0s7ok4uw	4941	24	regulation	regulation	NN
cord-001835-0s7ok4uw	4941	25	,	,	,
cord-001835-0s7ok4uw	4941	26	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	4941	27	stress	stress	NN
cord-001835-0s7ok4uw	4941	28	,	,	,
cord-001835-0s7ok4uw	4941	29	DNA	dna	NN
cord-001835-0s7ok4uw	4941	30	damage	damage	NN
cord-001835-0s7ok4uw	4941	31	,	,	,
cord-001835-0s7ok4uw	4941	32	energetic	energetic	JJ
cord-001835-0s7ok4uw	4941	33	and	and	CC
cord-001835-0s7ok4uw	4941	34	mRNA	mrna	NN
cord-001835-0s7ok4uw	4941	35	metabolism	metabolism	NN
cord-001835-0s7ok4uw	4941	36	[	[	-LRB-
cord-001835-0s7ok4uw	4941	37	3	3	CD
cord-001835-0s7ok4uw	4941	38	]	]	-RRB-
cord-001835-0s7ok4uw	4941	39	.	.	.
cord-001835-0s7ok4uw	4942	1	Strikingly	strikingly	RB
cord-001835-0s7ok4uw	4942	2	,	,	,
cord-001835-0s7ok4uw	4942	3	some	some	DT
cord-001835-0s7ok4uw	4942	4	of	of	IN
cord-001835-0s7ok4uw	4942	5	the	the	DT
cord-001835-0s7ok4uw	4942	6	novel	novel	JJ
cord-001835-0s7ok4uw	4942	7	human	human	JJ
cord-001835-0s7ok4uw	4942	8	Cc	Cc	NNP
cord-001835-0s7ok4uw	4942	9	-	-	HYPH
cord-001835-0s7ok4uw	4942	10	partners	partner	NNS
cord-001835-0s7ok4uw	4942	11	are	be	VBP
cord-001835-0s7ok4uw	4942	12	closely	closely	RB
cord-001835-0s7ok4uw	4942	13	related	related	JJ
cord-001835-0s7ok4uw	4942	14	to	to	IN
cord-001835-0s7ok4uw	4942	15	those	those	DT
cord-001835-0s7ok4uw	4942	16	for	for	IN
cord-001835-0s7ok4uw	4942	17	plant	plant	NN
cord-001835-0s7ok4uw	4942	18	Cc	Cc	NNP
cord-001835-0s7ok4uw	4942	19	,	,	,
cord-001835-0s7ok4uw	4942	20	so	so	CC
cord-001835-0s7ok4uw	4942	21	indicating	indicate	VBG
cord-001835-0s7ok4uw	4942	22	that	that	IN
cord-001835-0s7ok4uw	4942	23	the	the	DT
cord-001835-0s7ok4uw	4942	24	evolutionarily	evolutionarily	RB
cord-001835-0s7ok4uw	4942	25	well	well	RB
cord-001835-0s7ok4uw	4942	26	-	-	HYPH
cord-001835-0s7ok4uw	4942	27	conserved	conserve	VBN
cord-001835-0s7ok4uw	4942	28	event	event	NN
cord-001835-0s7ok4uw	4942	29	of	of	IN
cord-001835-0s7ok4uw	4942	30	Cc	Cc	NNP
cord-001835-0s7ok4uw	4942	31	release	release	NN
cord-001835-0s7ok4uw	4942	32	from	from	IN
cord-001835-0s7ok4uw	4942	33	mitochondria	mitochondrion	NNS
cord-001835-0s7ok4uw	4942	34	could	could	MD
cord-001835-0s7ok4uw	4942	35	involve	involve	VB
cord-001835-0s7ok4uw	4942	36	a	a	DT
cord-001835-0s7ok4uw	4942	37	common	common	JJ
cord-001835-0s7ok4uw	4942	38	signalosome	signalosome	NN
cord-001835-0s7ok4uw	4942	39	consisting	consist	VBG
cord-001835-0s7ok4uw	4942	40	of	of	IN
cord-001835-0s7ok4uw	4942	41	a	a	DT
cord-001835-0s7ok4uw	4942	42	wide	wide	JJ
cord-001835-0s7ok4uw	4942	43	range	range	NN
cord-001835-0s7ok4uw	4942	44	of	of	IN
cord-001835-0s7ok4uw	4942	45	common	common	JJ
cord-001835-0s7ok4uw	4942	46	targets	target	NNS
cord-001835-0s7ok4uw	4942	47	[	[	-LRB-
cord-001835-0s7ok4uw	4942	48	3	3	CD
cord-001835-0s7ok4uw	4942	49	]	]	-RRB-
cord-001835-0s7ok4uw	4942	50	.	.	.
cord-001835-0s7ok4uw	4943	1	To	to	TO
cord-001835-0s7ok4uw	4943	2	also	also	RB
cord-001835-0s7ok4uw	4943	3	understand	understand	VB
cord-001835-0s7ok4uw	4943	4	such	such	PDT
cord-001835-0s7ok4uw	4943	5	a	a	DT
cord-001835-0s7ok4uw	4943	6	promiscuity	promiscuity	NN
cord-001835-0s7ok4uw	4943	7	of	of	IN
cord-001835-0s7ok4uw	4943	8	Cc	Cc	NNP
cord-001835-0s7ok4uw	4943	9	from	from	IN
cord-001835-0s7ok4uw	4943	10	a	a	DT
cord-001835-0s7ok4uw	4943	11	structural	structural	JJ
cord-001835-0s7ok4uw	4943	12	point	point	NN
cord-001835-0s7ok4uw	4943	13	of	of	IN
cord-001835-0s7ok4uw	4943	14	view	view	NN
cord-001835-0s7ok4uw	4943	15	,	,	,
cord-001835-0s7ok4uw	4943	16	the	the	DT
cord-001835-0s7ok4uw	4943	17	Cc	cc	NN
cord-001835-0s7ok4uw	4943	18	surface	surface	NN
cord-001835-0s7ok4uw	4943	19	residues	residue	NNS
cord-001835-0s7ok4uw	4943	20	involved	involve	VBN
cord-001835-0s7ok4uw	4943	21	in	in	IN
cord-001835-0s7ok4uw	4943	22	complex	complex	JJ
cord-001835-0s7ok4uw	4943	23	formation	formation	NN
cord-001835-0s7ok4uw	4943	24	with	with	IN
cord-001835-0s7ok4uw	4943	25	each	each	DT
cord-001835-0s7ok4uw	4943	26	one	one	CD
cord-001835-0s7ok4uw	4943	27	of	of	IN
cord-001835-0s7ok4uw	4943	28	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4943	29	counterparts	counterpart	NNS
cord-001835-0s7ok4uw	4943	30	were	be	VBD
cord-001835-0s7ok4uw	4943	31	mapped	map	VBN
cord-001835-0s7ok4uw	4943	32	by	by	IN
cord-001835-0s7ok4uw	4943	33	using	use	VBG
cord-001835-0s7ok4uw	4943	34	NMR	NMR	NNP
cord-001835-0s7ok4uw	4943	35	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	4943	36	.	.	.
cord-001835-0s7ok4uw	4944	1	The	the	DT
cord-001835-0s7ok4uw	4944	2	resulting	result	VBG
cord-001835-0s7ok4uw	4944	3	data	data	NN
cord-001835-0s7ok4uw	4944	4	shows	show	VBZ
cord-001835-0s7ok4uw	4944	5	that	that	IN
cord-001835-0s7ok4uw	4944	6	the	the	DT
cord-001835-0s7ok4uw	4944	7	heme	heme	NN
cord-001835-0s7ok4uw	4944	8	crevice	crevice	NN
cord-001835-0s7ok4uw	4944	9	of	of	IN
cord-001835-0s7ok4uw	4944	10	Cc	Cc	NNP
cord-001835-0s7ok4uw	4944	11	is	be	VBZ
cord-001835-0s7ok4uw	4944	12	at	at	IN
cord-001835-0s7ok4uw	4944	13	the	the	DT
cord-001835-0s7ok4uw	4944	14	Cc	cc	NN
cord-001835-0s7ok4uw	4944	15	-	-	HYPH
cord-001835-0s7ok4uw	4944	16	partner	partner	NN
cord-001835-0s7ok4uw	4944	17	interface	interface	NN
cord-001835-0s7ok4uw	4944	18	in	in	IN
cord-001835-0s7ok4uw	4944	19	most	most	JJS
cord-001835-0s7ok4uw	4944	20	of	of	IN
cord-001835-0s7ok4uw	4944	21	the	the	DT
cord-001835-0s7ok4uw	4944	22	complexes	complex	NNS
cord-001835-0s7ok4uw	4944	23	,	,	,
cord-001835-0s7ok4uw	4944	24	which	which	WDT
cord-001835-0s7ok4uw	4944	25	is	be	VBZ
cord-001835-0s7ok4uw	4944	26	in	in	IN
cord-001835-0s7ok4uw	4944	27	agreement	agreement	NN
cord-001835-0s7ok4uw	4944	28	with	with	IN
cord-001835-0s7ok4uw	4944	29	the	the	DT
cord-001835-0s7ok4uw	4944	30	vast	vast	JJ
cord-001835-0s7ok4uw	4944	31	majority	majority	NN
cord-001835-0s7ok4uw	4944	32	of	of	IN
cord-001835-0s7ok4uw	4944	33	known	know	VBN
cord-001835-0s7ok4uw	4944	34	redox	redox	NN
cord-001835-0s7ok4uw	4944	35	adducts	adduct	NNS
cord-001835-0s7ok4uw	4944	36	of	of	IN
cord-001835-0s7ok4uw	4944	37	Cc	Cc	NNP
cord-001835-0s7ok4uw	4944	38	.	.	.
cord-001835-0s7ok4uw	4945	1	In	in	IN
cord-001835-0s7ok4uw	4945	2	contrast	contrast	NN
cord-001835-0s7ok4uw	4945	3	,	,	,
cord-001835-0s7ok4uw	4945	4	however	however	RB
cord-001835-0s7ok4uw	4945	5	,	,	,
cord-001835-0s7ok4uw	4945	6	to	to	IN
cord-001835-0s7ok4uw	4945	7	the	the	DT
cord-001835-0s7ok4uw	4945	8	high	high	JJ
cord-001835-0s7ok4uw	4945	9	turnover	turnover	NN
cord-001835-0s7ok4uw	4945	10	number	number	NN
cord-001835-0s7ok4uw	4945	11	of	of	IN
cord-001835-0s7ok4uw	4945	12	the	the	DT
cord-001835-0s7ok4uw	4945	13	redox	redox	NN
cord-001835-0s7ok4uw	4945	14	Cc	Cc	NNP
cord-001835-0s7ok4uw	4945	15	adducts	adduct	NNS
cord-001835-0s7ok4uw	4945	16	inside	inside	IN
cord-001835-0s7ok4uw	4945	17	the	the	DT
cord-001835-0s7ok4uw	4945	18	mitochondria	mitochondrion	NNS
cord-001835-0s7ok4uw	4945	19	,	,	,
cord-001835-0s7ok4uw	4945	20	the	the	DT
cord-001835-0s7ok4uw	4945	21	complexes	complex	NNS
cord-001835-0s7ok4uw	4945	22	formed	form	VBN
cord-001835-0s7ok4uw	4945	23	by	by	IN
cord-001835-0s7ok4uw	4945	24	Cc	Cc	NNP
cord-001835-0s7ok4uw	4945	25	under	under	IN
cord-001835-0s7ok4uw	4945	26	PCD	PCD	NNP
cord-001835-0s7ok4uw	4945	27	conditions	condition	NNS
cord-001835-0s7ok4uw	4945	28	lead	lead	VBP
cord-001835-0s7ok4uw	4945	29	to	to	IN
cord-001835-0s7ok4uw	4945	30	the	the	DT
cord-001835-0s7ok4uw	4945	31	formation	formation	NN
cord-001835-0s7ok4uw	4945	32	of	of	IN
cord-001835-0s7ok4uw	4945	33	rather	rather	RB
cord-001835-0s7ok4uw	4945	34	stable	stable	JJ
cord-001835-0s7ok4uw	4945	35	nucleo	nucleo	JJ
cord-001835-0s7ok4uw	4945	36	-	-	JJ
cord-001835-0s7ok4uw	4945	37	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	4945	38	ensembles	ensemble	NNS
cord-001835-0s7ok4uw	4945	39	.	.	.
cord-001835-0s7ok4uw	4946	1	Altogether	altogether	RB
cord-001835-0s7ok4uw	4946	2	,	,	,
cord-001835-0s7ok4uw	4946	3	these	these	DT
cord-001835-0s7ok4uw	4946	4	findings	finding	NNS
cord-001835-0s7ok4uw	4946	5	suggest	suggest	VBP
cord-001835-0s7ok4uw	4946	6	that	that	IN
cord-001835-0s7ok4uw	4946	7	extra	extra	JJ
cord-001835-0s7ok4uw	4946	8	-	-	HYPH
cord-001835-0s7ok4uw	4946	9	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	4946	10	Cc	Cc	NNP
cord-001835-0s7ok4uw	4946	11	interacts	interact	VBZ
cord-001835-0s7ok4uw	4946	12	with	with	IN
cord-001835-0s7ok4uw	4946	13	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	4946	14	and/or	and/or	CC
cord-001835-0s7ok4uw	4946	15	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	4946	16	pro	pro	JJ
cord-001835-0s7ok4uw	4946	17	-	-	JJ
cord-001835-0s7ok4uw	4946	18	survival	survival	JJ
cord-001835-0s7ok4uw	4946	19	,	,	,
cord-001835-0s7ok4uw	4946	20	anti	anti	JJ
cord-001835-0s7ok4uw	4946	21	-	-	JJ
cord-001835-0s7ok4uw	4946	22	apoptotic	apoptotic	JJ
cord-001835-0s7ok4uw	4946	23	proteins	protein	NNS
cord-001835-0s7ok4uw	4946	24	in	in	IN
cord-001835-0s7ok4uw	4946	25	both	both	DT
cord-001835-0s7ok4uw	4946	26	humans	human	NNS
cord-001835-0s7ok4uw	4946	27	and	and	CC
cord-001835-0s7ok4uw	4946	28	plants	plant	NNS
cord-001835-0s7ok4uw	4946	29	so	so	IN
cord-001835-0s7ok4uw	4946	30	as	as	IN
cord-001835-0s7ok4uw	4946	31	to	to	TO
cord-001835-0s7ok4uw	4946	32	lead	lead	VB
cord-001835-0s7ok4uw	4946	33	living	live	VBG
cord-001835-0s7ok4uw	4946	34	cells	cell	NNS
cord-001835-0s7ok4uw	4946	35	to	to	TO
cord-001835-0s7ok4uw	4946	36	dye	dye	VB
cord-001835-0s7ok4uw	4946	37	.	.	.
cord-001835-0s7ok4uw	4947	1	Keywords	keyword	NNS
cord-001835-0s7ok4uw	4947	2	:	:	:
cord-001835-0s7ok4uw	4947	3	Cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	4947	4	c	c	NN
cord-001835-0s7ok4uw	4947	5	,	,	,
cord-001835-0s7ok4uw	4947	6	Programmed	program	VBN
cord-001835-0s7ok4uw	4947	7	Cell	Cell	NNP
cord-001835-0s7ok4uw	4947	8	Death	Death	NNP
cord-001835-0s7ok4uw	4947	9	,	,	,
cord-001835-0s7ok4uw	4947	10	Signalosome	Signalosome	NNP
cord-001835-0s7ok4uw	4947	11	.	.	.
cord-001835-0s7ok4uw	4948	1	Post	post	JJ
cord-001835-0s7ok4uw	4948	2	-	-	JJ
cord-001835-0s7ok4uw	4948	3	translational	translational	JJ
cord-001835-0s7ok4uw	4948	4	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4948	5	often	often	RB
cord-001835-0s7ok4uw	4948	6	modulates	modulate	VBZ
cord-001835-0s7ok4uw	4948	7	the	the	DT
cord-001835-0s7ok4uw	4948	8	function	function	NN
cord-001835-0s7ok4uw	4948	9	of	of	IN
cord-001835-0s7ok4uw	4948	10	proteins	protein	NNS
cord-001835-0s7ok4uw	4948	11	.	.	.
cord-001835-0s7ok4uw	4949	1	In	in	IN
cord-001835-0s7ok4uw	4949	2	particular	particular	JJ
cord-001835-0s7ok4uw	4949	3	,	,	,
cord-001835-0s7ok4uw	4949	4	they	-PRON-	PRP
cord-001835-0s7ok4uw	4949	5	affect	affect	VBP
cord-001835-0s7ok4uw	4949	6	the	the	DT
cord-001835-0s7ok4uw	4949	7	role	role	NN
cord-001835-0s7ok4uw	4949	8	that	that	WDT
cord-001835-0s7ok4uw	4949	9	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	4949	10	c	c	NN
cord-001835-0s7ok4uw	4949	11	(	(	-LRB-
cord-001835-0s7ok4uw	4949	12	Cc	cc	NN
cord-001835-0s7ok4uw	4949	13	)	)	-RRB-
cord-001835-0s7ok4uw	4949	14	plays	play	VBZ
cord-001835-0s7ok4uw	4949	15	in	in	IN
cord-001835-0s7ok4uw	4949	16	cell	cell	NN
cord-001835-0s7ok4uw	4949	17	life	life	NN
cord-001835-0s7ok4uw	4949	18	and	and	CC
cord-001835-0s7ok4uw	4949	19	death	death	NN
cord-001835-0s7ok4uw	4949	20	[	[	-LRB-
cord-001835-0s7ok4uw	4949	21	1	1	CD
cord-001835-0s7ok4uw	4949	22	]	]	-RRB-
cord-001835-0s7ok4uw	4949	23	.	.	.
cord-001835-0s7ok4uw	4950	1	Cc	Cc	NNP
cord-001835-0s7ok4uw	4950	2	is	be	VBZ
cord-001835-0s7ok4uw	4950	3	phosphorylated	phosphorylate	VBN
cord-001835-0s7ok4uw	4950	4	in	in	IN
cord-001835-0s7ok4uw	4950	5	vivo	vivo	NN
cord-001835-0s7ok4uw	4950	6	in	in	IN
cord-001835-0s7ok4uw	4950	7	Tyr48	Tyr48	NNP
cord-001835-0s7ok4uw	4950	8	and	and	CC
cord-001835-0s7ok4uw	4950	9	Tyr97	Tyr97	NNP
cord-001835-0s7ok4uw	4950	10	residues	residue	NNS
cord-001835-0s7ok4uw	4950	11	[	[	-LRB-
cord-001835-0s7ok4uw	4950	12	2	2	CD
cord-001835-0s7ok4uw	4950	13	,	,	,
cord-001835-0s7ok4uw	4950	14	3	3	CD
cord-001835-0s7ok4uw	4950	15	]	]	-RRB-
cord-001835-0s7ok4uw	4950	16	,	,	,
cord-001835-0s7ok4uw	4950	17	but	but	CC
cord-001835-0s7ok4uw	4950	18	recently	recently	RB
cord-001835-0s7ok4uw	4950	19	,	,	,
cord-001835-0s7ok4uw	4950	20	two	two	CD
cord-001835-0s7ok4uw	4950	21	new	new	JJ
cord-001835-0s7ok4uw	4950	22	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4950	23	sites	site	NNS
cord-001835-0s7ok4uw	4950	24	have	have	VBP
cord-001835-0s7ok4uw	4950	25	been	be	VBN
cord-001835-0s7ok4uw	4950	26	described	describe	VBN
cord-001835-0s7ok4uw	4950	27	at	at	IN
cord-001835-0s7ok4uw	4950	28	positions	position	NNS
cord-001835-0s7ok4uw	4950	29	28	28	CD
cord-001835-0s7ok4uw	4950	30	and	and	CC
cord-001835-0s7ok4uw	4950	31	47	47	CD
cord-001835-0s7ok4uw	4950	32	[	[	-LRB-
cord-001835-0s7ok4uw	4950	33	4	4	CD
cord-001835-0s7ok4uw	4950	34	]	]	-RRB-
cord-001835-0s7ok4uw	4950	35	.	.	.
cord-001835-0s7ok4uw	4951	1	Hence	hence	RB
cord-001835-0s7ok4uw	4951	2	,	,	,
cord-001835-0s7ok4uw	4951	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4951	4	aim	aim	VBP
cord-001835-0s7ok4uw	4951	5	at	at	IN
cord-001835-0s7ok4uw	4951	6	understanding	understand	VBG
cord-001835-0s7ok4uw	4951	7	the	the	DT
cord-001835-0s7ok4uw	4951	8	structural	structural	JJ
cord-001835-0s7ok4uw	4951	9	and	and	CC
cord-001835-0s7ok4uw	4951	10	functional	functional	JJ
cord-001835-0s7ok4uw	4951	11	changes	change	NNS
cord-001835-0s7ok4uw	4951	12	induced	induce	VBN
cord-001835-0s7ok4uw	4951	13	by	by	IN
cord-001835-0s7ok4uw	4951	14	Thr28	Thr28	NNP
cord-001835-0s7ok4uw	4951	15	and	and	CC
cord-001835-0s7ok4uw	4951	16	Ser47	Ser47	NNP
cord-001835-0s7ok4uw	4951	17	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4951	18	Cc	Cc	NNP
cord-001835-0s7ok4uw	4951	19	.	.	.
cord-001835-0s7ok4uw	4952	1	For	for	IN
cord-001835-0s7ok4uw	4952	2	this	this	DT
cord-001835-0s7ok4uw	4952	3	purpose	purpose	NN
cord-001835-0s7ok4uw	4952	4	,	,	,
cord-001835-0s7ok4uw	4952	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	4952	6	designed	design	VBD
cord-001835-0s7ok4uw	4952	7	two	two	CD
cord-001835-0s7ok4uw	4952	8	phosphomimetic	phosphomimetic	JJ
cord-001835-0s7ok4uw	4952	9	mutants	mutant	NNS
cord-001835-0s7ok4uw	4952	10	of	of	IN
cord-001835-0s7ok4uw	4952	11	Cc	Cc	NNP
cord-001835-0s7ok4uw	4952	12	by	by	IN
cord-001835-0s7ok4uw	4952	13	replacing	replace	VBG
cord-001835-0s7ok4uw	4952	14	either	either	CC
cord-001835-0s7ok4uw	4952	15	Thr28	Thr28	NNP
cord-001835-0s7ok4uw	4952	16	or	or	CC
cord-001835-0s7ok4uw	4952	17	Ser47	Ser47	NNPS
cord-001835-0s7ok4uw	4952	18	by	by	IN
cord-001835-0s7ok4uw	4952	19	the	the	DT
cord-001835-0s7ok4uw	4952	20	canonical	canonical	JJ
cord-001835-0s7ok4uw	4952	21	amino	amino	NN
cord-001835-0s7ok4uw	4952	22	acid	acid	NN
cord-001835-0s7ok4uw	4952	23	aspartic	aspartic	JJ
cord-001835-0s7ok4uw	4952	24	acid	acid	NN
cord-001835-0s7ok4uw	4952	25	(	(	-LRB-
cord-001835-0s7ok4uw	4952	26	T28D	t28d	NN
cord-001835-0s7ok4uw	4952	27	and	and	CC
cord-001835-0s7ok4uw	4952	28	S47D	s47d	NN
cord-001835-0s7ok4uw	4952	29	)	)	-RRB-
cord-001835-0s7ok4uw	4952	30	.	.	.
cord-001835-0s7ok4uw	4953	1	As	as	IN
cord-001835-0s7ok4uw	4953	2	control	control	NN
cord-001835-0s7ok4uw	4953	3	,	,	,
cord-001835-0s7ok4uw	4953	4	two	two	CD
cord-001835-0s7ok4uw	4953	5	other	other	JJ
cord-001835-0s7ok4uw	4953	6	mutants	mutant	NNS
cord-001835-0s7ok4uw	4953	7	at	at	IN
cord-001835-0s7ok4uw	4953	8	the	the	DT
cord-001835-0s7ok4uw	4953	9	same	same	JJ
cord-001835-0s7ok4uw	4953	10	two	two	CD
cord-001835-0s7ok4uw	4953	11	positions	position	NNS
cord-001835-0s7ok4uw	4953	12	(	(	-LRB-
cord-001835-0s7ok4uw	4953	13	T28A	t28a	NN
cord-001835-0s7ok4uw	4953	14	and	and	CC
cord-001835-0s7ok4uw	4953	15	S47A	S47A	NNP
cord-001835-0s7ok4uw	4953	16	)	)	-RRB-
cord-001835-0s7ok4uw	4953	17	were	be	VBD
cord-001835-0s7ok4uw	4953	18	analyzed	analyze	VBN
cord-001835-0s7ok4uw	4953	19	so	so	IN
cord-001835-0s7ok4uw	4953	20	as	as	IN
cord-001835-0s7ok4uw	4953	21	to	to	TO
cord-001835-0s7ok4uw	4953	22	differentiate	differentiate	VB
cord-001835-0s7ok4uw	4953	23	the	the	DT
cord-001835-0s7ok4uw	4953	24	effects	effect	NNS
cord-001835-0s7ok4uw	4953	25	due	due	IN
cord-001835-0s7ok4uw	4953	26	to	to	IN
cord-001835-0s7ok4uw	4953	27	the	the	DT
cord-001835-0s7ok4uw	4953	28	presence	presence	NN
cord-001835-0s7ok4uw	4953	29	of	of	IN
cord-001835-0s7ok4uw	4953	30	a	a	DT
cord-001835-0s7ok4uw	4953	31	negatively	negatively	RB
cord-001835-0s7ok4uw	4953	32	charged	charge	VBN
cord-001835-0s7ok4uw	4953	33	residue	residue	NN
cord-001835-0s7ok4uw	4953	34	.	.	.
cord-001835-0s7ok4uw	4954	1	Remarkably	remarkably	RB
cord-001835-0s7ok4uw	4954	2	,	,	,
cord-001835-0s7ok4uw	4954	3	the	the	DT
cord-001835-0s7ok4uw	4954	4	S47A	S47A	NNP
cord-001835-0s7ok4uw	4954	5	mutant	mutant	NN
cord-001835-0s7ok4uw	4954	6	is	be	VBZ
cord-001835-0s7ok4uw	4954	7	significantly	significantly	RB
cord-001835-0s7ok4uw	4954	8	less	less	RBR
cord-001835-0s7ok4uw	4954	9	stable	stable	JJ
cord-001835-0s7ok4uw	4954	10	than	than	IN
cord-001835-0s7ok4uw	4954	11	the	the	DT
cord-001835-0s7ok4uw	4954	12	wild	wild	JJ
cord-001835-0s7ok4uw	4954	13	-	-	HYPH
cord-001835-0s7ok4uw	4954	14	type	type	NN
cord-001835-0s7ok4uw	4954	15	species	specie	NNS
cord-001835-0s7ok4uw	4954	16	.	.	.
cord-001835-0s7ok4uw	4955	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4955	2	found	find	VBD
cord-001835-0s7ok4uw	4955	3	that	that	IN
cord-001835-0s7ok4uw	4955	4	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4955	5	at	at	IN
cord-001835-0s7ok4uw	4955	6	position	position	NN
cord-001835-0s7ok4uw	4955	7	Thr28	Thr28	NNP
cord-001835-0s7ok4uw	4955	8	diminishes	diminish	VBZ
cord-001835-0s7ok4uw	4955	9	the	the	DT
cord-001835-0s7ok4uw	4955	10	redox	redox	NN
cord-001835-0s7ok4uw	4955	11	potential	potential	NN
cord-001835-0s7ok4uw	4955	12	and	and	CC
cord-001835-0s7ok4uw	4955	13	oxygen	oxygen	NN
cord-001835-0s7ok4uw	4955	14	consumption	consumption	NN
cord-001835-0s7ok4uw	4955	15	.	.	.
cord-001835-0s7ok4uw	4956	1	In	in	IN
cord-001835-0s7ok4uw	4956	2	addition	addition	NN
cord-001835-0s7ok4uw	4956	3	,	,	,
cord-001835-0s7ok4uw	4956	4	T28D	T28D	NNP
cord-001835-0s7ok4uw	4956	5	mutation	mutation	NN
cord-001835-0s7ok4uw	4956	6	affects	affect	VBZ
cord-001835-0s7ok4uw	4956	7	the	the	DT
cord-001835-0s7ok4uw	4956	8	ability	ability	NN
cord-001835-0s7ok4uw	4956	9	of	of	IN
cord-001835-0s7ok4uw	4956	10	Cc	Cc	NNP
cord-001835-0s7ok4uw	4956	11	to	to	TO
cord-001835-0s7ok4uw	4956	12	bind	bind	VB
cord-001835-0s7ok4uw	4956	13	the	the	DT
cord-001835-0s7ok4uw	4956	14	distal	distal	JJ
cord-001835-0s7ok4uw	4956	15	site	site	NN
cord-001835-0s7ok4uw	4956	16	pCc1	pCc1	''
cord-001835-0s7ok4uw	4956	17	,	,	,
cord-001835-0s7ok4uw	4956	18	thereby	thereby	RB
cord-001835-0s7ok4uw	4956	19	suggesting	suggest	VBG
cord-001835-0s7ok4uw	4956	20	that	that	IN
cord-001835-0s7ok4uw	4956	21	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	4956	22	at	at	IN
cord-001835-0s7ok4uw	4956	23	this	this	DT
cord-001835-0s7ok4uw	4956	24	position	position	NN
cord-001835-0s7ok4uw	4956	25	affects	affect	VBZ
cord-001835-0s7ok4uw	4956	26	the	the	DT
cord-001835-0s7ok4uw	4956	27	electron	electron	NN
cord-001835-0s7ok4uw	4956	28	carrier	carrier	NN
cord-001835-0s7ok4uw	4956	29	capacity	capacity	NN
cord-001835-0s7ok4uw	4956	30	of	of	IN
cord-001835-0s7ok4uw	4956	31	Cc	Cc	NNP
cord-001835-0s7ok4uw	4956	32	.	.	.
cord-001835-0s7ok4uw	4956	33	 	 	_SP
cord-001835-0s7ok4uw	4957	1	Mass	mass	NN
cord-001835-0s7ok4uw	4957	2	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4957	3	(	(	-LRB-
cord-001835-0s7ok4uw	4957	4	MS	MS	NNP
cord-001835-0s7ok4uw	4957	5	)	)	-RRB-
cord-001835-0s7ok4uw	4957	6	is	be	VBZ
cord-001835-0s7ok4uw	4957	7	widely	widely	RB
cord-001835-0s7ok4uw	4957	8	used	use	VBN
cord-001835-0s7ok4uw	4957	9	techniques	technique	NNS
cord-001835-0s7ok4uw	4957	10	to	to	TO
cord-001835-0s7ok4uw	4957	11	gain	gain	VB
cord-001835-0s7ok4uw	4957	12	knowledge	knowledge	NN
cord-001835-0s7ok4uw	4957	13	about	about	IN
cord-001835-0s7ok4uw	4957	14	biomolecules	biomolecule	NNS
cord-001835-0s7ok4uw	4957	15	[	[	-LRB-
cord-001835-0s7ok4uw	4957	16	1	1	CD
cord-001835-0s7ok4uw	4957	17	,	,	,
cord-001835-0s7ok4uw	4957	18	2	2	CD
cord-001835-0s7ok4uw	4957	19	]	]	-RRB-
cord-001835-0s7ok4uw	4957	20	.	.	.
cord-001835-0s7ok4uw	4958	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4958	2	produces	produce	VBZ
cord-001835-0s7ok4uw	4958	3	a	a	DT
cord-001835-0s7ok4uw	4958	4	high	high	JJ
cord-001835-0s7ok4uw	4958	5	amount	amount	NN
cord-001835-0s7ok4uw	4958	6	of	of	IN
cord-001835-0s7ok4uw	4958	7	data	datum	NNS
cord-001835-0s7ok4uw	4958	8	which	which	WDT
cord-001835-0s7ok4uw	4958	9	is	be	VBZ
cord-001835-0s7ok4uw	4958	10	often	often	RB
cord-001835-0s7ok4uw	4958	11	presented	present	VBN
cord-001835-0s7ok4uw	4958	12	as	as	IN
cord-001835-0s7ok4uw	4958	13	a	a	DT
cord-001835-0s7ok4uw	4958	14	list	list	NN
cord-001835-0s7ok4uw	4958	15	containing	contain	VBG
cord-001835-0s7ok4uw	4958	16	thousands	thousand	NNS
cord-001835-0s7ok4uw	4958	17	of	of	IN
cord-001835-0s7ok4uw	4958	18	proteins	protein	NNS
cord-001835-0s7ok4uw	4958	19	.	.	.
cord-001835-0s7ok4uw	4959	1	That	that	DT
cord-001835-0s7ok4uw	4959	2	list	list	NN
cord-001835-0s7ok4uw	4959	3	usually	usually	RB
cord-001835-0s7ok4uw	4959	4	contains	contain	VBZ
cord-001835-0s7ok4uw	4959	5	few	few	JJ
cord-001835-0s7ok4uw	4959	6	hits	hit	NNS
cord-001835-0s7ok4uw	4959	7	interesting	interesting	JJ
cord-001835-0s7ok4uw	4959	8	for	for	IN
cord-001835-0s7ok4uw	4959	9	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4959	10	research	research	NN
cord-001835-0s7ok4uw	4959	11	.	.	.
cord-001835-0s7ok4uw	4960	1	The	the	DT
cord-001835-0s7ok4uw	4960	2	pocess	pocess	NN
cord-001835-0s7ok4uw	4960	3	to	to	TO
cord-001835-0s7ok4uw	4960	4	select	select	VB
cord-001835-0s7ok4uw	4960	5	those	those	DT
cord-001835-0s7ok4uw	4960	6	proteins	protein	NNS
cord-001835-0s7ok4uw	4960	7	may	may	MD
cord-001835-0s7ok4uw	4960	8	include	include	VB
cord-001835-0s7ok4uw	4960	9	integrating	integrate	VBG
cord-001835-0s7ok4uw	4960	10	experimental	experimental	JJ
cord-001835-0s7ok4uw	4960	11	with	with	IN
cord-001835-0s7ok4uw	4960	12	annotation	annotation	NN
cord-001835-0s7ok4uw	4960	13	data	datum	NNS
cord-001835-0s7ok4uw	4960	14	.	.	.
cord-001835-0s7ok4uw	4961	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	4961	2	requires	require	VBZ
cord-001835-0s7ok4uw	4961	3	spending	spend	VBG
cord-001835-0s7ok4uw	4961	4	some	some	DT
cord-001835-0s7ok4uw	4961	5	time	time	NN
cord-001835-0s7ok4uw	4961	6	in	in	IN
cord-001835-0s7ok4uw	4961	7	both	both	DT
cord-001835-0s7ok4uw	4961	8	,	,	,
cord-001835-0s7ok4uw	4961	9	performing	perform	VBG
cord-001835-0s7ok4uw	4961	10	calculus	calculus	NN
cord-001835-0s7ok4uw	4961	11	and	and	CC
cord-001835-0s7ok4uw	4961	12	searching	search	VBG
cord-001835-0s7ok4uw	4961	13	in	in	IN
cord-001835-0s7ok4uw	4961	14	databases	database	NNS
cord-001835-0s7ok4uw	4961	15	.	.	.
cord-001835-0s7ok4uw	4962	1	In	in	IN
cord-001835-0s7ok4uw	4962	2	this	this	DT
cord-001835-0s7ok4uw	4962	3	poster	poster	NN
cord-001835-0s7ok4uw	4962	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	4962	5	present	present	VBP
cord-001835-0s7ok4uw	4962	6	msBiodata	msBiodata	NNP
cord-001835-0s7ok4uw	4962	7	Analysis	Analysis	NNP
cord-001835-0s7ok4uw	4962	8	Tool	Tool	NNP
cord-001835-0s7ok4uw	4962	9	,	,	,
cord-001835-0s7ok4uw	4962	10	a	a	DT
cord-001835-0s7ok4uw	4962	11	web	web	NN
cord-001835-0s7ok4uw	4962	12	service	service	NN
cord-001835-0s7ok4uw	4962	13	thought	think	VBN
cord-001835-0s7ok4uw	4962	14	to	to	TO
cord-001835-0s7ok4uw	4962	15	deal	deal	VB
cord-001835-0s7ok4uw	4962	16	with	with	IN
cord-001835-0s7ok4uw	4962	17	this	this	DT
cord-001835-0s7ok4uw	4962	18	tedious	tedious	JJ
cord-001835-0s7ok4uw	4962	19	work	work	NN
cord-001835-0s7ok4uw	4962	20	.	.	.
cord-001835-0s7ok4uw	4963	1	With	with	IN
cord-001835-0s7ok4uw	4963	2	this	this	DT
cord-001835-0s7ok4uw	4963	3	tool	tool	NN
cord-001835-0s7ok4uw	4963	4	,	,	,
cord-001835-0s7ok4uw	4963	5	researchers	researcher	NNS
cord-001835-0s7ok4uw	4963	6	can	can	MD
cord-001835-0s7ok4uw	4963	7	set	set	VB
cord-001835-0s7ok4uw	4963	8	rules	rule	NNS
cord-001835-0s7ok4uw	4963	9	to	to	TO
cord-001835-0s7ok4uw	4963	10	select	select	VB
cord-001835-0s7ok4uw	4963	11	the	the	DT
cord-001835-0s7ok4uw	4963	12	most	most	RBS
cord-001835-0s7ok4uw	4963	13	interesting	interesting	JJ
cord-001835-0s7ok4uw	4963	14	hits	hit	NNS
cord-001835-0s7ok4uw	4963	15	in	in	IN
cord-001835-0s7ok4uw	4963	16	his	-PRON-	PRP$
cord-001835-0s7ok4uw	4963	17	lists	list	NNS
cord-001835-0s7ok4uw	4963	18	using	use	VBG
cord-001835-0s7ok4uw	4963	19	both	both	DT
cord-001835-0s7ok4uw	4963	20	,	,	,
cord-001835-0s7ok4uw	4963	21	experimental	experimental	JJ
cord-001835-0s7ok4uw	4963	22	data	datum	NNS
cord-001835-0s7ok4uw	4963	23	and	and	CC
cord-001835-0s7ok4uw	4963	24	Gene	Gene	NNP
cord-001835-0s7ok4uw	4963	25	Ontology	Ontology	NNP
cord-001835-0s7ok4uw	4963	26	[	[	-LRB-
cord-001835-0s7ok4uw	4963	27	3	3	CD
cord-001835-0s7ok4uw	4963	28	]	]	-RRB-
cord-001835-0s7ok4uw	4963	29	annotation	annotation	NN
cord-001835-0s7ok4uw	4963	30	.	.	.
cord-001835-0s7ok4uw	4964	1	The	the	DT
cord-001835-0s7ok4uw	4964	2	data	datum	NNS
cord-001835-0s7ok4uw	4964	3	can	can	MD
cord-001835-0s7ok4uw	4964	4	be	be	VB
cord-001835-0s7ok4uw	4964	5	upload	upload	VB
cord-001835-0s7ok4uw	4964	6	to	to	IN
cord-001835-0s7ok4uw	4964	7	the	the	DT
cord-001835-0s7ok4uw	4964	8	web	web	NN
cord-001835-0s7ok4uw	4964	9	using	use	VBG
cord-001835-0s7ok4uw	4964	10	an	an	DT
cord-001835-0s7ok4uw	4964	11	excel	excel	JJ
cord-001835-0s7ok4uw	4964	12	spreadsheet	spreadsheet	NN
cord-001835-0s7ok4uw	4964	13	or	or	CC
cord-001835-0s7ok4uw	4964	14	a	a	DT
cord-001835-0s7ok4uw	4964	15	flat	flat	JJ
cord-001835-0s7ok4uw	4964	16	files	file	NNS
cord-001835-0s7ok4uw	4964	17	in	in	IN
cord-001835-0s7ok4uw	4964	18	a	a	DT
cord-001835-0s7ok4uw	4964	19	mztab	mztab	NNP
cord-001835-0s7ok4uw	4964	20	format	format	NN
cord-001835-0s7ok4uw	4964	21	,	,	,
cord-001835-0s7ok4uw	4964	22	and	and	CC
cord-001835-0s7ok4uw	4964	23	rules	rule	NNS
cord-001835-0s7ok4uw	4964	24	are	be	VBP
cord-001835-0s7ok4uw	4964	25	easily	easily	RB
cord-001835-0s7ok4uw	4964	26	constructed	construct	VBN
cord-001835-0s7ok4uw	4964	27	by	by	IN
cord-001835-0s7ok4uw	4964	28	means	mean	VBZ
cord-001835-0s7ok4uw	4964	29	logical	logical	JJ
cord-001835-0s7ok4uw	4964	30	sentences	sentence	NNS
cord-001835-0s7ok4uw	4964	31	.	.	.
cord-001835-0s7ok4uw	4965	1	Those	those	DT
cord-001835-0s7ok4uw	4965	2	sentences	sentence	NNS
cord-001835-0s7ok4uw	4965	3	are	be	VBP
cord-001835-0s7ok4uw	4965	4	composed	compose	VBN
cord-001835-0s7ok4uw	4965	5	by	by	IN
cord-001835-0s7ok4uw	4965	6	one	one	CD
cord-001835-0s7ok4uw	4965	7	or	or	CC
cord-001835-0s7ok4uw	4965	8	more	more	JJR
cord-001835-0s7ok4uw	4965	9	terms	term	NNS
cord-001835-0s7ok4uw	4965	10	linked	link	VBN
cord-001835-0s7ok4uw	4965	11	by	by	IN
cord-001835-0s7ok4uw	4965	12	logic	logic	NN
cord-001835-0s7ok4uw	4965	13	operators	operator	NNS
cord-001835-0s7ok4uw	4965	14	(	(	-LRB-
cord-001835-0s7ok4uw	4965	15	and	and	CC
cord-001835-0s7ok4uw	4965	16	and	and	CC
cord-001835-0s7ok4uw	4965	17	or	or	CC
cord-001835-0s7ok4uw	4965	18	)	)	-RRB-
cord-001835-0s7ok4uw	4965	19	.	.	.
cord-001835-0s7ok4uw	4966	1	Each	each	DT
cord-001835-0s7ok4uw	4966	2	term	term	NN
cord-001835-0s7ok4uw	4966	3	in	in	IN
cord-001835-0s7ok4uw	4966	4	the	the	DT
cord-001835-0s7ok4uw	4966	5	logical	logical	JJ
cord-001835-0s7ok4uw	4966	6	sentence	sentence	NN
cord-001835-0s7ok4uw	4966	7	indicates	indicate	VBZ
cord-001835-0s7ok4uw	4966	8	to	to	IN
cord-001835-0s7ok4uw	4966	9	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4966	10	program	program	NN
cord-001835-0s7ok4uw	4966	11	the	the	DT
cord-001835-0s7ok4uw	4966	12	conditions	condition	NNS
cord-001835-0s7ok4uw	4966	13	1	1	CD
cord-001835-0s7ok4uw	4966	14	that	that	WDT
cord-001835-0s7ok4uw	4966	15	selected	select	VBN
cord-001835-0s7ok4uw	4966	16	hits	hit	NNS
cord-001835-0s7ok4uw	4966	17	must	must	MD
cord-001835-0s7ok4uw	4966	18	meet	meet	VB
cord-001835-0s7ok4uw	4966	19	.	.	.
cord-001835-0s7ok4uw	4967	1	Once	once	IN
cord-001835-0s7ok4uw	4967	2	the	the	DT
cord-001835-0s7ok4uw	4967	3	alysis	alysis	NN
cord-001835-0s7ok4uw	4967	4	is	be	VBZ
cord-001835-0s7ok4uw	4967	5	finished	finish	VBN
cord-001835-0s7ok4uw	4967	6	,	,	,
cord-001835-0s7ok4uw	4967	7	the	the	DT
cord-001835-0s7ok4uw	4967	8	results	result	NNS
cord-001835-0s7ok4uw	4967	9	are	be	VBP
cord-001835-0s7ok4uw	4967	10	delivered	deliver	VBN
cord-001835-0s7ok4uw	4967	11	by	by	IN
cord-001835-0s7ok4uw	4967	12	email	email	NN
cord-001835-0s7ok4uw	4967	13	.	.	.
cord-001835-0s7ok4uw	4968	1	msBiodat	msbiodat	NN
cord-001835-0s7ok4uw	4968	2	analysis	analysis	NN
cord-001835-0s7ok4uw	4968	3	tool	tool	NN
cord-001835-0s7ok4uw	4968	4	do	do	VBP
cord-001835-0s7ok4uw	4968	5	not	not	RB
cord-001835-0s7ok4uw	4968	6	requires	require	VBZ
cord-001835-0s7ok4uw	4968	7	any	any	DT
cord-001835-0s7ok4uw	4968	8	programming	programming	NN
cord-001835-0s7ok4uw	4968	9	knowledge	knowledge	NN
cord-001835-0s7ok4uw	4968	10	to	to	TO
cord-001835-0s7ok4uw	4968	11	be	be	VB
cord-001835-0s7ok4uw	4968	12	used	use	VBN
cord-001835-0s7ok4uw	4968	13	and	and	CC
cord-001835-0s7ok4uw	4968	14	is	be	VBZ
cord-001835-0s7ok4uw	4968	15	freely	freely	RB
cord-001835-0s7ok4uw	4968	16	available	available	JJ
cord-001835-0s7ok4uw	4968	17	at	at	IN
cord-001835-0s7ok4uw	4968	18	:	:	:
cord-001835-0s7ok4uw	4968	19	http://msbiodata.innomol.eu	http://msbiodata.innomol.eu	XX
cord-001835-0s7ok4uw	4969	1	Keywords	Keywords	NNP
cord-001835-0s7ok4uw	4969	2	Bioinformatics	Bioinformatics	NNP
cord-001835-0s7ok4uw	4969	3	/	/	SYM
cord-001835-0s7ok4uw	4969	4	Data	Data	NNP
cord-001835-0s7ok4uw	4969	5	analysis	analysis	NN
cord-001835-0s7ok4uw	4969	6	/	/	SYM
cord-001835-0s7ok4uw	4969	7	proteomics	proteomic	NNS
cord-001835-0s7ok4uw	4969	8	/	/	SYM
cord-001835-0s7ok4uw	4969	9	Data	Data	NNP
cord-001835-0s7ok4uw	4969	10	mining/	mining/	CD
cord-001835-0s7ok4uw	4969	11	Mass	mass	NN
cord-001835-0s7ok4uw	4969	12	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	4969	13	.	.	.
cord-001835-0s7ok4uw	4970	1	Beside	beside	IN
cord-001835-0s7ok4uw	4970	2	the	the	DT
cord-001835-0s7ok4uw	4970	3	rate	rate	NN
cord-001835-0s7ok4uw	4970	4	of	of	IN
cord-001835-0s7ok4uw	4970	5	protein	protein	NN
cord-001835-0s7ok4uw	4970	6	synthesis	synthesis	NN
cord-001835-0s7ok4uw	4970	7	,	,	,
cord-001835-0s7ok4uw	4970	8	the	the	DT
cord-001835-0s7ok4uw	4970	9	regulation	regulation	NN
cord-001835-0s7ok4uw	4970	10	of	of	IN
cord-001835-0s7ok4uw	4970	11	protein	protein	NN
cord-001835-0s7ok4uw	4970	12	degradation	degradation	NN
cord-001835-0s7ok4uw	4970	13	plays	play	VBZ
cord-001835-0s7ok4uw	4970	14	a	a	DT
cord-001835-0s7ok4uw	4970	15	crucial	crucial	JJ
cord-001835-0s7ok4uw	4970	16	role	role	NN
cord-001835-0s7ok4uw	4970	17	in	in	IN
cord-001835-0s7ok4uw	4970	18	the	the	DT
cord-001835-0s7ok4uw	4970	19	white	white	JJ
cord-001835-0s7ok4uw	4970	20	muscle	muscle	NN
cord-001835-0s7ok4uw	4970	21	protein	protein	NN
cord-001835-0s7ok4uw	4970	22	accumulation	accumulation	NN
cord-001835-0s7ok4uw	4970	23	and	and	CC
cord-001835-0s7ok4uw	4970	24	overall	overall	JJ
cord-001835-0s7ok4uw	4970	25	fish	fish	NN
cord-001835-0s7ok4uw	4970	26	growth	growth	NN
cord-001835-0s7ok4uw	4970	27	.	.	.
cord-001835-0s7ok4uw	4971	1	Intracellular	Intracellular	NNP
cord-001835-0s7ok4uw	4971	2	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	4971	3	in	in	IN
cord-001835-0s7ok4uw	4971	4	salmonid	salmonid	JJ
cord-001835-0s7ok4uw	4971	5	species	specie	NNS
cord-001835-0s7ok4uw	4971	6	,	,	,
cord-001835-0s7ok4uw	4971	7	such	such	JJ
cord-001835-0s7ok4uw	4971	8	as	as	IN
cord-001835-0s7ok4uw	4971	9	Atlantic	Atlantic	NNP
cord-001835-0s7ok4uw	4971	10	salmon	salmon	NN
cord-001835-0s7ok4uw	4971	11	,	,	,
cord-001835-0s7ok4uw	4971	12	Salmo	Salmo	NNP
cord-001835-0s7ok4uw	4971	13	salar	salar	NNP
cord-001835-0s7ok4uw	4971	14	L.	L.	NNP
cord-001835-0s7ok4uw	4971	15	and	and	CC
cord-001835-0s7ok4uw	4971	16	rainbow	rainbow	NN
cord-001835-0s7ok4uw	4971	17	trout	trout	NNS
cord-001835-0s7ok4uw	4971	18	,	,	,
cord-001835-0s7ok4uw	4971	19	Oncorhynchus	Oncorhynchus	NNP
cord-001835-0s7ok4uw	4971	20	mykiss	mykiss	NN
cord-001835-0s7ok4uw	4971	21	Walb	Walb	NNP
cord-001835-0s7ok4uw	4971	22	.	.	.
cord-001835-0s7ok4uw	4972	1	,	,	,
cord-001835-0s7ok4uw	4972	2	was	be	VBD
cord-001835-0s7ok4uw	4972	3	studied	study	VBN
cord-001835-0s7ok4uw	4972	4	to	to	TO
cord-001835-0s7ok4uw	4972	5	evaluate	evaluate	VB
cord-001835-0s7ok4uw	4972	6	the	the	DT
cord-001835-0s7ok4uw	4972	7	basic	basic	JJ
cord-001835-0s7ok4uw	4972	8	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4972	9	of	of	IN
cord-001835-0s7ok4uw	4972	10	protein	protein	NN
cord-001835-0s7ok4uw	4972	11	degradation	degradation	NN
cord-001835-0s7ok4uw	4972	12	that	that	WDT
cord-001835-0s7ok4uw	4972	13	could	could	MD
cord-001835-0s7ok4uw	4972	14	possess	possess	VB
cord-001835-0s7ok4uw	4972	15	a	a	DT
cord-001835-0s7ok4uw	4972	16	potential	potential	JJ
cord-001835-0s7ok4uw	4972	17	target	target	NN
cord-001835-0s7ok4uw	4972	18	to	to	TO
cord-001835-0s7ok4uw	4972	19	regulate	regulate	VB
cord-001835-0s7ok4uw	4972	20	the	the	DT
cord-001835-0s7ok4uw	4972	21	body	body	NN
cord-001835-0s7ok4uw	4972	22	mass	mass	NN
cord-001835-0s7ok4uw	4972	23	accumulation	accumulation	NN
cord-001835-0s7ok4uw	4972	24	in	in	IN
cord-001835-0s7ok4uw	4972	25	farmed	farm	VBN
cord-001835-0s7ok4uw	4972	26	fish	fish	NN
cord-001835-0s7ok4uw	4972	27	.	.	.
cord-001835-0s7ok4uw	4973	1	A	a	DT
cord-001835-0s7ok4uw	4973	2	number	number	NN
cord-001835-0s7ok4uw	4973	3	of	of	IN
cord-001835-0s7ok4uw	4973	4	white	white	JJ
cord-001835-0s7ok4uw	4973	5	muscle	muscle	NN
cord-001835-0s7ok4uw	4973	6	proteases	protease	NNS
cord-001835-0s7ok4uw	4973	7	such	such	JJ
cord-001835-0s7ok4uw	4973	8	as	as	IN
cord-001835-0s7ok4uw	4973	9	cathepsins	cathepsin	NNS
cord-001835-0s7ok4uw	4973	10	B	B	NNP
cord-001835-0s7ok4uw	4973	11	,	,	,
cord-001835-0s7ok4uw	4973	12	L	L	NNP
cord-001835-0s7ok4uw	4973	13	,	,	,
cord-001835-0s7ok4uw	4973	14	and	and	CC
cord-001835-0s7ok4uw	4973	15	D	D	NNP
cord-001835-0s7ok4uw	4973	16	,	,	,
cord-001835-0s7ok4uw	4973	17	proteasomes	proteasomes	NNP
cord-001835-0s7ok4uw	4973	18	,	,	,
cord-001835-0s7ok4uw	4973	19	and	and	CC
cord-001835-0s7ok4uw	4973	20	calcium	calcium	NN
cord-001835-0s7ok4uw	4973	21	-	-	HYPH
cord-001835-0s7ok4uw	4973	22	dependent	dependent	JJ
cord-001835-0s7ok4uw	4973	23	proteases	protease	NNS
cord-001835-0s7ok4uw	4973	24	(	(	-LRB-
cord-001835-0s7ok4uw	4973	25	m	m	NNP
cord-001835-0s7ok4uw	4973	26	-	-	:
cord-001835-0s7ok4uw	4973	27	and	and	CC
cord-001835-0s7ok4uw	4973	28	m	m	NNP
cord-001835-0s7ok4uw	4973	29	-	-	HYPH
cord-001835-0s7ok4uw	4973	30	calpains	calpains	NNP
cord-001835-0s7ok4uw	4973	31	)	)	-RRB-
cord-001835-0s7ok4uw	4973	32	,	,	,
cord-001835-0s7ok4uw	4973	33	was	be	VBD
cord-001835-0s7ok4uw	4973	34	studied	study	VBN
cord-001835-0s7ok4uw	4973	35	in	in	IN
cord-001835-0s7ok4uw	4973	36	the	the	DT
cord-001835-0s7ok4uw	4973	37	juvenile	juvenile	JJ
cord-001835-0s7ok4uw	4973	38	specimens	specimen	NNS
cord-001835-0s7ok4uw	4973	39	of	of	IN
cord-001835-0s7ok4uw	4973	40	different	different	JJ
cord-001835-0s7ok4uw	4973	41	size	size	NN
cord-001835-0s7ok4uw	4973	42	-	-	:
cord-001835-0s7ok4uw	4973	43	and	and	CC
cord-001835-0s7ok4uw	4973	44	age	age	NN
cord-001835-0s7ok4uw	4973	45	-	-	HYPH
cord-001835-0s7ok4uw	4973	46	groups	group	NNS
cord-001835-0s7ok4uw	4973	47	both	both	CC
cord-001835-0s7ok4uw	4973	48	wild	wild	JJ
cord-001835-0s7ok4uw	4973	49	and	and	CC
cord-001835-0s7ok4uw	4973	50	farmed	farmed	JJ
cord-001835-0s7ok4uw	4973	51	salmonids	salmonid	NNS
cord-001835-0s7ok4uw	4973	52	.	.	.
cord-001835-0s7ok4uw	4974	1	The	the	DT
cord-001835-0s7ok4uw	4974	2	correlations	correlation	NNS
cord-001835-0s7ok4uw	4974	3	between	between	IN
cord-001835-0s7ok4uw	4974	4	the	the	DT
cord-001835-0s7ok4uw	4974	5	protease	protease	NN
cord-001835-0s7ok4uw	4974	6	activity	activity	NN
cord-001835-0s7ok4uw	4974	7	and	and	CC
cord-001835-0s7ok4uw	4974	8	expression	expression	NN
cord-001835-0s7ok4uw	4974	9	levels	level	NNS
cord-001835-0s7ok4uw	4974	10	and	and	CC
cord-001835-0s7ok4uw	4974	11	morphometric	morphometric	JJ
cord-001835-0s7ok4uw	4974	12	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	4974	13	of	of	IN
cord-001835-0s7ok4uw	4974	14	fish	fish	NN
cord-001835-0s7ok4uw	4974	15	were	be	VBD
cord-001835-0s7ok4uw	4974	16	found	find	VBN
cord-001835-0s7ok4uw	4974	17	.	.	.
cord-001835-0s7ok4uw	4975	1	The	the	DT
cord-001835-0s7ok4uw	4975	2	size	size	NN
cord-001835-0s7ok4uw	4975	3	-	-	HYPH
cord-001835-0s7ok4uw	4975	4	and	and	CC
cord-001835-0s7ok4uw	4975	5	age	age	NN
cord-001835-0s7ok4uw	4975	6	-	-	HYPH
cord-001835-0s7ok4uw	4975	7	related	relate	VBN
cord-001835-0s7ok4uw	4975	8	differences	difference	NNS
cord-001835-0s7ok4uw	4975	9	in	in	IN
cord-001835-0s7ok4uw	4975	10	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	4975	11	protease	protease	NN
cord-001835-0s7ok4uw	4975	12	activity	activity	NN
cord-001835-0s7ok4uw	4975	13	revealed	reveal	VBN
cord-001835-0s7ok4uw	4975	14	in	in	IN
cord-001835-0s7ok4uw	4975	15	fish	fish	NN
cord-001835-0s7ok4uw	4975	16	muscles	muscle	NNS
cord-001835-0s7ok4uw	4975	17	indicate	indicate	VBP
cord-001835-0s7ok4uw	4975	18	both	both	DT
cord-001835-0s7ok4uw	4975	19	general	general	JJ
cord-001835-0s7ok4uw	4975	20	role	role	NN
cord-001835-0s7ok4uw	4975	21	of	of	IN
cord-001835-0s7ok4uw	4975	22	proteolysis	proteolysis	NN
cord-001835-0s7ok4uw	4975	23	regulation	regulation	NN
cord-001835-0s7ok4uw	4975	24	in	in	IN
cord-001835-0s7ok4uw	4975	25	salmonid	salmonid	JJ
cord-001835-0s7ok4uw	4975	26	growth	growth	NN
cord-001835-0s7ok4uw	4975	27	and	and	CC
cord-001835-0s7ok4uw	4975	28	the	the	DT
cord-001835-0s7ok4uw	4975	29	specific	specific	JJ
cord-001835-0s7ok4uw	4975	30	role	role	NN
cord-001835-0s7ok4uw	4975	31	of	of	IN
cord-001835-0s7ok4uw	4975	32	the	the	DT
cord-001835-0s7ok4uw	4975	33	individual	individual	JJ
cord-001835-0s7ok4uw	4975	34	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	4975	35	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4975	36	as	as	RB
cord-001835-0s7ok4uw	4975	37	well	well	RB
cord-001835-0s7ok4uw	4975	38	.	.	.
cord-001835-0s7ok4uw	4976	1	The	the	DT
cord-001835-0s7ok4uw	4976	2	data	datum	NNS
cord-001835-0s7ok4uw	4976	3	on	on	IN
cord-001835-0s7ok4uw	4976	4	negative	negative	JJ
cord-001835-0s7ok4uw	4976	5	correlation	correlation	NN
cord-001835-0s7ok4uw	4976	6	of	of	IN
cord-001835-0s7ok4uw	4976	7	cathepsin	cathepsin	NN
cord-001835-0s7ok4uw	4976	8	D	d	NN
cord-001835-0s7ok4uw	4976	9	and	and	CC
cord-001835-0s7ok4uw	4976	10	calpain	calpain	NN
cord-001835-0s7ok4uw	4976	11	activity	activity	NN
cord-001835-0s7ok4uw	4976	12	in	in	IN
cord-001835-0s7ok4uw	4976	13	muscles	muscle	NNS
cord-001835-0s7ok4uw	4976	14	and	and	CC
cord-001835-0s7ok4uw	4976	15	the	the	DT
cord-001835-0s7ok4uw	4976	16	rate	rate	NN
cord-001835-0s7ok4uw	4976	17	of	of	IN
cord-001835-0s7ok4uw	4976	18	weight	weight	NN
cord-001835-0s7ok4uw	4976	19	increase	increase	NN
cord-001835-0s7ok4uw	4976	20	in	in	IN
cord-001835-0s7ok4uw	4976	21	juvenile	juvenile	JJ
cord-001835-0s7ok4uw	4976	22	salmonids	salmonid	NNS
cord-001835-0s7ok4uw	4976	23	were	be	VBD
cord-001835-0s7ok4uw	4976	24	obtained	obtain	VBN
cord-001835-0s7ok4uw	4976	25	.	.	.
cord-001835-0s7ok4uw	4977	1	A	a	DT
cord-001835-0s7ok4uw	4977	2	revealed	reveal	VBN
cord-001835-0s7ok4uw	4977	3	positive	positive	JJ
cord-001835-0s7ok4uw	4977	4	correlation	correlation	NN
cord-001835-0s7ok4uw	4977	5	of	of	IN
cord-001835-0s7ok4uw	4977	6	cathepsin	cathepsin	NN
cord-001835-0s7ok4uw	4977	7	B	b	NN
cord-001835-0s7ok4uw	4977	8	activity	activity	NN
cord-001835-0s7ok4uw	4977	9	and	and	CC
cord-001835-0s7ok4uw	4977	10	morphometric	morphometric	JJ
cord-001835-0s7ok4uw	4977	11	parameters	parameter	NNS
cord-001835-0s7ok4uw	4977	12	in	in	IN
cord-001835-0s7ok4uw	4977	13	fish	fish	NN
cord-001835-0s7ok4uw	4977	14	young	young	JJ
cord-001835-0s7ok4uw	4978	1	presumably	presumably	RB
cord-001835-0s7ok4uw	4978	2	indicates	indicate	VBZ
cord-001835-0s7ok4uw	4978	3	its	-PRON-	PRP$
cord-001835-0s7ok4uw	4978	4	primary	primary	JJ
cord-001835-0s7ok4uw	4978	5	contribution	contribution	NN
cord-001835-0s7ok4uw	4978	6	to	to	IN
cord-001835-0s7ok4uw	4978	7	non	non	JJ
cord-001835-0s7ok4uw	4978	8	-	-	JJ
cord-001835-0s7ok4uw	4978	9	myofibrillar	myofibrillar	JJ
cord-001835-0s7ok4uw	4978	10	protein	protein	NN
cord-001835-0s7ok4uw	4978	11	turnover	turnover	NN
cord-001835-0s7ok4uw	4978	12	.	.	.
cord-001835-0s7ok4uw	4979	1	Ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	4979	2	-	-	HYPH
cord-001835-0s7ok4uw	4979	3	proteasome	proteasome	NN
cord-001835-0s7ok4uw	4979	4	system	system	NN
cord-001835-0s7ok4uw	4979	5	seems	seem	VBZ
cord-001835-0s7ok4uw	4979	6	to	to	TO
cord-001835-0s7ok4uw	4979	7	contribute	contribute	VB
cord-001835-0s7ok4uw	4979	8	to	to	IN
cord-001835-0s7ok4uw	4979	9	background	background	NN
cord-001835-0s7ok4uw	4979	10	protein	protein	NN
cord-001835-0s7ok4uw	4979	11	turnover	turnover	NN
cord-001835-0s7ok4uw	4979	12	as	as	IN
cord-001835-0s7ok4uw	4979	13	the	the	DT
cord-001835-0s7ok4uw	4979	14	proteasome	proteasome	NN
cord-001835-0s7ok4uw	4979	15	activity	activity	NN
cord-001835-0s7ok4uw	4979	16	was	be	VBD
cord-001835-0s7ok4uw	4979	17	not	not	RB
cord-001835-0s7ok4uw	4979	18	corresponded	correspond	VBN
cord-001835-0s7ok4uw	4979	19	with	with	IN
cord-001835-0s7ok4uw	4979	20	growth	growth	NN
cord-001835-0s7ok4uw	4979	21	rate	rate	NN
cord-001835-0s7ok4uw	4979	22	.	.	.
cord-001835-0s7ok4uw	4980	1	Summarizing	summarize	VBG
cord-001835-0s7ok4uw	4980	2	the	the	DT
cord-001835-0s7ok4uw	4980	3	data	datum	NNS
cord-001835-0s7ok4uw	4980	4	obtained	obtain	VBD
cord-001835-0s7ok4uw	4980	5	the	the	DT
cord-001835-0s7ok4uw	4980	6	autophagy	autophagy	NN
cord-001835-0s7ok4uw	4980	7	-	-	HYPH
cord-001835-0s7ok4uw	4980	8	lysosomal	lysosomal	NN
cord-001835-0s7ok4uw	4980	9	and	and	CC
cord-001835-0s7ok4uw	4980	10	calpain	calpain	NN
cord-001835-0s7ok4uw	4980	11	-	-	HYPH
cord-001835-0s7ok4uw	4980	12	related	relate	VBN
cord-001835-0s7ok4uw	4980	13	protein	protein	NN
cord-001835-0s7ok4uw	4980	14	degradation	degradation	NN
cord-001835-0s7ok4uw	4980	15	pathways	pathway	NNS
cord-001835-0s7ok4uw	4980	16	were	be	VBD
cord-001835-0s7ok4uw	4980	17	recognized	recognize	VBN
cord-001835-0s7ok4uw	4980	18	to	to	TO
cord-001835-0s7ok4uw	4980	19	be	be	VB
cord-001835-0s7ok4uw	4980	20	directly	directly	RB
cord-001835-0s7ok4uw	4980	21	involved	involve	VBN
cord-001835-0s7ok4uw	4980	22	in	in	IN
cord-001835-0s7ok4uw	4980	23	body	body	NN
cord-001835-0s7ok4uw	4980	24	growth	growth	NN
cord-001835-0s7ok4uw	4980	25	and	and	CC
cord-001835-0s7ok4uw	4980	26	muscle	muscle	NN
cord-001835-0s7ok4uw	4980	27	protein	protein	NN
cord-001835-0s7ok4uw	4980	28	retention	retention	NN
cord-001835-0s7ok4uw	4980	29	in	in	IN
cord-001835-0s7ok4uw	4980	30	salmonid	salmonid	JJ
cord-001835-0s7ok4uw	4980	31	fish	fish	NN
cord-001835-0s7ok4uw	4980	32	.	.	.
cord-001835-0s7ok4uw	4981	1	The	the	DT
cord-001835-0s7ok4uw	4981	2	work	work	NN
cord-001835-0s7ok4uw	4981	3	was	be	VBD
cord-001835-0s7ok4uw	4981	4	carried	carry	VBN
cord-001835-0s7ok4uw	4981	5	out	out	RP
cord-001835-0s7ok4uw	4981	6	using	use	VBG
cord-001835-0s7ok4uw	4981	7	technical	technical	JJ
cord-001835-0s7ok4uw	4981	8	facilities	facility	NNS
cord-001835-0s7ok4uw	4981	9	of	of	IN
cord-001835-0s7ok4uw	4981	10	IB	IB	NNP
cord-001835-0s7ok4uw	4981	11	KarRC	KarRC	NNP
cord-001835-0s7ok4uw	4981	12	RAS	RAS	NNP
cord-001835-0s7ok4uw	4981	13	Equipment	Equipment	NNP
cord-001835-0s7ok4uw	4981	14	Centre	Centre	NNP
cord-001835-0s7ok4uw	4981	15	and	and	CC
cord-001835-0s7ok4uw	4981	16	financially	financially	RB
cord-001835-0s7ok4uw	4981	17	supported	support	VBN
cord-001835-0s7ok4uw	4981	18	by	by	IN
cord-001835-0s7ok4uw	4981	19	the	the	DT
cord-001835-0s7ok4uw	4981	20	Russian	Russian	NNP
cord-001835-0s7ok4uw	4981	21	Science	Science	NNP
cord-001835-0s7ok4uw	4981	22	Foundation	Foundation	NNP
cord-001835-0s7ok4uw	4981	23	,	,	,
cord-001835-0s7ok4uw	4981	24	grant	grant	VBP
cord-001835-0s7ok4uw	4981	25	No	no	NN
cord-001835-0s7ok4uw	4981	26	.	.	NN
cord-001835-0s7ok4uw	4981	27	14	14	CD
cord-001835-0s7ok4uw	4981	28	-	-	HYPH
cord-001835-0s7ok4uw	4981	29	24	24	CD
cord-001835-0s7ok4uw	4981	30	-	-	HYPH
cord-001835-0s7ok4uw	4981	31	00102	00102	CD
cord-001835-0s7ok4uw	4982	1	"	"	``
cord-001835-0s7ok4uw	4982	2	Salmonids	Salmonids	NNP
cord-001835-0s7ok4uw	4982	3	of	of	IN
cord-001835-0s7ok4uw	4982	4	the	the	DT
cord-001835-0s7ok4uw	4982	5	North	North	NNP
cord-001835-0s7ok4uw	4982	6	-	-	HYPH
cord-001835-0s7ok4uw	4982	7	West	West	NNP
cord-001835-0s7ok4uw	4982	8	Russia	Russia	NNP
cord-001835-0s7ok4uw	4982	9	:	:	:
cord-001835-0s7ok4uw	4982	10	ecological	ecological	JJ
cord-001835-0s7ok4uw	4982	11	and	and	CC
cord-001835-0s7ok4uw	4982	12	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	4982	13	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4982	14	of	of	IN
cord-001835-0s7ok4uw	4982	15	early	early	JJ
cord-001835-0s7ok4uw	4982	16	development	development	NN
cord-001835-0s7ok4uw	4982	17	"	"	''
cord-001835-0s7ok4uw	4982	18	.	.	.
cord-001835-0s7ok4uw	4983	1	Solving	solve	VBG
cord-001835-0s7ok4uw	4983	2	the	the	DT
cord-001835-0s7ok4uw	4983	3	proteomic	proteomic	JJ
cord-001835-0s7ok4uw	4983	4	organization	organization	NN
cord-001835-0s7ok4uw	4983	5	of	of	IN
cord-001835-0s7ok4uw	4983	6	fitness	fitness	NN
cord-001835-0s7ok4uw	4983	7	-	-	HYPH
cord-001835-0s7ok4uw	4983	8	related	relate	VBN
cord-001835-0s7ok4uw	4983	9	genes	gene	NNS
cord-001835-0s7ok4uw	4983	10	in	in	IN
cord-001835-0s7ok4uw	4983	11	Uropathogenic	Uropathogenic	NNP
cord-001835-0s7ok4uw	4983	12	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	4983	13	coli	coli	NNS
cord-001835-0s7ok4uw	4983	14	in	in	IN
cord-001835-0s7ok4uw	4983	15	life	life	NN
cord-001835-0s7ok4uw	4983	16	threatening	threaten	VBG
cord-001835-0s7ok4uw	4983	17	sepsis	sepsis	NN
cord-001835-0s7ok4uw	4983	18	.	.	.
cord-001835-0s7ok4uw	4984	1	Nowadays	nowadays	RB
cord-001835-0s7ok4uw	4984	2	,	,	,
cord-001835-0s7ok4uw	4984	3	complete	complete	JJ
cord-001835-0s7ok4uw	4984	4	genomes	genome	NNS
cord-001835-0s7ok4uw	4984	5	for	for	IN
cord-001835-0s7ok4uw	4984	6	almost	almost	RB
cord-001835-0s7ok4uw	4984	7	all	all	DT
cord-001835-0s7ok4uw	4984	8	major	major	JJ
cord-001835-0s7ok4uw	4984	9	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	4984	10	pathogens	pathogen	NNS
cord-001835-0s7ok4uw	4984	11	are	be	VBP
cord-001835-0s7ok4uw	4984	12	available	available	JJ
cord-001835-0s7ok4uw	4984	13	,	,	,
cord-001835-0s7ok4uw	4984	14	helping	help	VBG
cord-001835-0s7ok4uw	4984	15	researchers	researcher	NNS
cord-001835-0s7ok4uw	4984	16	to	to	TO
cord-001835-0s7ok4uw	4984	17	identify	identify	VB
cord-001835-0s7ok4uw	4984	18	virulence	virulence	NN
cord-001835-0s7ok4uw	4984	19	factors	factor	NNS
cord-001835-0s7ok4uw	4984	20	.	.	.
cord-001835-0s7ok4uw	4985	1	However	however	RB
cord-001835-0s7ok4uw	4985	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	4985	3	still	still	RB
cord-001835-0s7ok4uw	4985	4	ignore	ignore	VBP
cord-001835-0s7ok4uw	4985	5	how	how	WRB
cord-001835-0s7ok4uw	4985	6	these	these	DT
cord-001835-0s7ok4uw	4985	7	genes	gene	NNS
cord-001835-0s7ok4uw	4985	8	are	be	VBP
cord-001835-0s7ok4uw	4985	9	organized	organize	VBN
cord-001835-0s7ok4uw	4985	10	at	at	IN
cord-001835-0s7ok4uw	4985	11	the	the	DT
cord-001835-0s7ok4uw	4985	12	proteome	proteome	NN
cord-001835-0s7ok4uw	4985	13	level	level	NN
cord-001835-0s7ok4uw	4985	14	and	and	CC
cord-001835-0s7ok4uw	4985	15	how	how	WRB
cord-001835-0s7ok4uw	4985	16	this	this	DT
cord-001835-0s7ok4uw	4985	17	association	association	NN
cord-001835-0s7ok4uw	4985	18	influences	influence	VBZ
cord-001835-0s7ok4uw	4985	19	bacteria	bacteria	VBZ
cord-001835-0s7ok4uw	4985	20	pathogenicity	pathogenicity	NN
cord-001835-0s7ok4uw	4985	21	.	.	.
cord-001835-0s7ok4uw	4986	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	4986	2	integrated	integrate	VBD
cord-001835-0s7ok4uw	4986	3	available	available	JJ
cord-001835-0s7ok4uw	4986	4	databases	database	NNS
cord-001835-0s7ok4uw	4986	5	on	on	IN
cord-001835-0s7ok4uw	4986	6	UPEC	UPEC	NNP
cord-001835-0s7ok4uw	4986	7	E.	E.	NNP
cord-001835-0s7ok4uw	4986	8	coli	coli	NNS
cord-001835-0s7ok4uw	4986	9	(	(	-LRB-
cord-001835-0s7ok4uw	4986	10	strain	strain	NN
cord-001835-0s7ok4uw	4986	11	CFT073	CFT073	NNP
cord-001835-0s7ok4uw	4986	12	)	)	-RRB-
cord-001835-0s7ok4uw	4986	13	to	to	TO
cord-001835-0s7ok4uw	4986	14	investigate	investigate	VB
cord-001835-0s7ok4uw	4986	15	the	the	DT
cord-001835-0s7ok4uw	4986	16	genomic	genomic	JJ
cord-001835-0s7ok4uw	4986	17	and	and	CC
cord-001835-0s7ok4uw	4986	18	proteomic	proteomic	JJ
cord-001835-0s7ok4uw	4986	19	organization	organization	NN
cord-001835-0s7ok4uw	4986	20	of	of	IN
cord-001835-0s7ok4uw	4986	21	genes	gene	NNS
cord-001835-0s7ok4uw	4986	22	related	relate	VBN
cord-001835-0s7ok4uw	4986	23	to	to	IN
cord-001835-0s7ok4uw	4986	24	UPEC	UPEC	NNP
cord-001835-0s7ok4uw	4986	25	fitness	fitness	NN
cord-001835-0s7ok4uw	4986	26	in	in	IN
cord-001835-0s7ok4uw	4986	27	the	the	DT
cord-001835-0s7ok4uw	4986	28	host	host	NN
cord-001835-0s7ok4uw	4986	29	.	.	.
cord-001835-0s7ok4uw	4987	1	Intriguingly	intriguingly	RB
cord-001835-0s7ok4uw	4987	2	,	,	,
cord-001835-0s7ok4uw	4987	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	4987	4	found	find	VBD
cord-001835-0s7ok4uw	4987	5	that	that	IN
cord-001835-0s7ok4uw	4987	6	most	most	JJS
cord-001835-0s7ok4uw	4987	7	fitnessrelated	fitnessrelate	VBN
cord-001835-0s7ok4uw	4987	8	genes	gene	NNS
cord-001835-0s7ok4uw	4987	9	have	have	VBP
cord-001835-0s7ok4uw	4987	10	orthologs	ortholog	NNS
cord-001835-0s7ok4uw	4987	11	not	not	RB
cord-001835-0s7ok4uw	4987	12	only	only	RB
cord-001835-0s7ok4uw	4987	13	in	in	IN
cord-001835-0s7ok4uw	4987	14	other	other	JJ
cord-001835-0s7ok4uw	4987	15	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	4987	16	strains	strain	NNS
cord-001835-0s7ok4uw	4987	17	but	but	CC
cord-001835-0s7ok4uw	4987	18	also	also	RB
cord-001835-0s7ok4uw	4987	19	in	in	IN
cord-001835-0s7ok4uw	4987	20	non	non	JJ
cord-001835-0s7ok4uw	4987	21	-	-	JJ
cord-001835-0s7ok4uw	4987	22	pathogenic	pathogenic	JJ
cord-001835-0s7ok4uw	4987	23	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	4987	24	such	such	JJ
cord-001835-0s7ok4uw	4987	25	as	as	IN
cord-001835-0s7ok4uw	4987	26	E.	E.	NNP
cord-001835-0s7ok4uw	4987	27	coli	coli	VBZ
cord-001835-0s7ok4uw	4987	28	K-12	K-12	NNP
cord-001835-0s7ok4uw	4987	29	.	.	.
cord-001835-0s7ok4uw	4988	1	These	these	DT
cord-001835-0s7ok4uw	4988	2	genes	gene	NNS
cord-001835-0s7ok4uw	4988	3	are	be	VBP
cord-001835-0s7ok4uw	4988	4	organized	organize	VBN
cord-001835-0s7ok4uw	4988	5	in	in	IN
cord-001835-0s7ok4uw	4988	6	clusters	cluster	NNS
cord-001835-0s7ok4uw	4988	7	and	and	CC
cord-001835-0s7ok4uw	4988	8	operons	operon	NNS
cord-001835-0s7ok4uw	4988	9	with	with	IN
cord-001835-0s7ok4uw	4988	10	similar	similar	JJ
cord-001835-0s7ok4uw	4988	11	structure	structure	NN
cord-001835-0s7ok4uw	4988	12	.	.	.
cord-001835-0s7ok4uw	4989	1	By	by	IN
cord-001835-0s7ok4uw	4989	2	integrating	integrate	VBG
cord-001835-0s7ok4uw	4989	3	protein	protein	NN
cord-001835-0s7ok4uw	4989	4	-	-	HYPH
cord-001835-0s7ok4uw	4989	5	protein	protein	NN
cord-001835-0s7ok4uw	4989	6	interaction	interaction	NN
cord-001835-0s7ok4uw	4989	7	data	datum	NNS
cord-001835-0s7ok4uw	4989	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	4989	9	observed	observe	VBD
cord-001835-0s7ok4uw	4989	10	that	that	IN
cord-001835-0s7ok4uw	4989	11	genes	gene	NNS
cord-001835-0s7ok4uw	4989	12	with	with	IN
cord-001835-0s7ok4uw	4989	13	high	high	JJ
cord-001835-0s7ok4uw	4989	14	impact	impact	NN
cord-001835-0s7ok4uw	4989	15	on	on	IN
cord-001835-0s7ok4uw	4989	16	fitness	fitness	NN
cord-001835-0s7ok4uw	4989	17	also	also	RB
cord-001835-0s7ok4uw	4989	18	display	display	VBP
cord-001835-0s7ok4uw	4989	19	a	a	DT
cord-001835-0s7ok4uw	4989	20	highly	highly	RB
cord-001835-0s7ok4uw	4989	21	clustered	clustered	JJ
cord-001835-0s7ok4uw	4989	22	organization	organization	NN
cord-001835-0s7ok4uw	4989	23	when	when	WRB
cord-001835-0s7ok4uw	4989	24	compared	compare	VBN
cord-001835-0s7ok4uw	4989	25	to	to	IN
cord-001835-0s7ok4uw	4989	26	other	other	JJ
cord-001835-0s7ok4uw	4989	27	genes	gene	NNS
cord-001835-0s7ok4uw	4989	28	.	.	.
cord-001835-0s7ok4uw	4990	1	Overall	overall	RB
cord-001835-0s7ok4uw	4990	2	,	,	,
cord-001835-0s7ok4uw	4990	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	4990	4	results	result	NNS
cord-001835-0s7ok4uw	4990	5	show	show	VBP
cord-001835-0s7ok4uw	4990	6	that	that	IN
cord-001835-0s7ok4uw	4990	7	proteinprotein	proteinprotein	NNP
cord-001835-0s7ok4uw	4990	8	interaction	interaction	NN
cord-001835-0s7ok4uw	4990	9	clusters	cluster	NNS
cord-001835-0s7ok4uw	4990	10	associated	associate	VBN
cord-001835-0s7ok4uw	4990	11	to	to	IN
cord-001835-0s7ok4uw	4990	12	UPEC	UPEC	NNP
cord-001835-0s7ok4uw	4990	13	fitness	fitness	NN
cord-001835-0s7ok4uw	4990	14	in	in	IN
cord-001835-0s7ok4uw	4990	15	the	the	DT
cord-001835-0s7ok4uw	4990	16	host	host	NN
cord-001835-0s7ok4uw	4990	17	represent	represent	VBP
cord-001835-0s7ok4uw	4990	18	a	a	DT
cord-001835-0s7ok4uw	4990	19	promising	promising	JJ
cord-001835-0s7ok4uw	4990	20	target	target	NN
cord-001835-0s7ok4uw	4990	21	for	for	IN
cord-001835-0s7ok4uw	4990	22	the	the	DT
cord-001835-0s7ok4uw	4990	23	design	design	NN
cord-001835-0s7ok4uw	4990	24	of	of	IN
cord-001835-0s7ok4uw	4990	25	new	new	JJ
cord-001835-0s7ok4uw	4990	26	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	4990	27	.	.	.
cord-001835-0s7ok4uw	4991	1	Elucidating	elucidate	VBG
cord-001835-0s7ok4uw	4991	2	the	the	DT
cord-001835-0s7ok4uw	4991	3	molecular	molecular	JJ
cord-001835-0s7ok4uw	4991	4	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	4991	5	by	by	IN
cord-001835-0s7ok4uw	4991	6	which	which	WDT
cord-001835-0s7ok4uw	4991	7	the	the	DT
cord-001835-0s7ok4uw	4991	8	HNH	HNH	NNP
cord-001835-0s7ok4uw	4991	9	endonuclease	endonuclease	NN
cord-001835-0s7ok4uw	4991	10	gp74	gp74	NN
cord-001835-0s7ok4uw	4991	11	activates	activate	VBZ
cord-001835-0s7ok4uw	4991	12	the	the	DT
cord-001835-0s7ok4uw	4991	13	terminases	terminase	NNS
cord-001835-0s7ok4uw	4991	14	in	in	IN
cord-001835-0s7ok4uw	4991	15	bacteriophage	bacteriophage	NN
cord-001835-0s7ok4uw	4991	16	HK97	HK97	NNP
cord-001835-0s7ok4uw	4991	17	(	(	-LRB-
cord-001835-0s7ok4uw	4991	18	2	2	CD
cord-001835-0s7ok4uw	4991	19	)	)	-RRB-
cord-001835-0s7ok4uw	4991	20	.	.	.
cord-001835-0s7ok4uw	4992	1	HNH	HNH	NNP
cord-001835-0s7ok4uw	4992	2	endonucleases	endonuclease	NNS
cord-001835-0s7ok4uw	4992	3	are	be	VBP
cord-001835-0s7ok4uw	4992	4	characterized	characterize	VBN
cord-001835-0s7ok4uw	4992	5	by	by	IN
cord-001835-0s7ok4uw	4992	6	two	two	CD
cord-001835-0s7ok4uw	4992	7	highly	highly	RB
cord-001835-0s7ok4uw	4992	8	conserved	conserve	VBD
cord-001835-0s7ok4uw	4992	9	His	-PRON-	PRP$
cord-001835-0s7ok4uw	4992	10	residues	residue	NNS
cord-001835-0s7ok4uw	4992	11	and	and	CC
cord-001835-0s7ok4uw	4992	12	an	an	DT
cord-001835-0s7ok4uw	4992	13	Asn	Asn	NNP
cord-001835-0s7ok4uw	4992	14	residue(3	residue(3	CD
cord-001835-0s7ok4uw	4992	15	)	)	-RRB-
cord-001835-0s7ok4uw	4992	16	.	.	.
cord-001835-0s7ok4uw	4993	1	Gp74	Gp74	NNP
cord-001835-0s7ok4uw	4993	2	is	be	VBZ
cord-001835-0s7ok4uw	4993	3	essential	essential	JJ
cord-001835-0s7ok4uw	4993	4	for	for	IN
cord-001835-0s7ok4uw	4993	5	phage	phage	NN
cord-001835-0s7ok4uw	4993	6	head	head	NN
cord-001835-0s7ok4uw	4993	7	morphogenesis	morphogenesis	NN
cord-001835-0s7ok4uw	4993	8	,	,	,
cord-001835-0s7ok4uw	4993	9	likely	likely	RB
cord-001835-0s7ok4uw	4993	10	because	because	IN
cord-001835-0s7ok4uw	4993	11	gp74	gp74	NNP
cord-001835-0s7ok4uw	4993	12	enhances	enhance	VBZ
cord-001835-0s7ok4uw	4993	13	the	the	DT
cord-001835-0s7ok4uw	4993	14	activity	activity	NN
cord-001835-0s7ok4uw	4993	15	of	of	IN
cord-001835-0s7ok4uw	4993	16	the	the	DT
cord-001835-0s7ok4uw	4993	17	HK97	HK97	NNP
cord-001835-0s7ok4uw	4993	18	terminase	terminase	NN
cord-001835-0s7ok4uw	4993	19	enzymes	enzyme	VBZ
cord-001835-0s7ok4uw	4993	20	toward	toward	IN
cord-001835-0s7ok4uw	4993	21	the	the	DT
cord-001835-0s7ok4uw	4993	22	cos	cos	NNP
cord-001835-0s7ok4uw	4993	23	site	site	NN
cord-001835-0s7ok4uw	4993	24	(	(	-LRB-
cord-001835-0s7ok4uw	4993	25	4	4	CD
cord-001835-0s7ok4uw	4993	26	)	)	-RRB-
cord-001835-0s7ok4uw	4993	27	.	.	.
cord-001835-0s7ok4uw	4994	1	Notably	notably	RB
cord-001835-0s7ok4uw	4994	2	,	,	,
cord-001835-0s7ok4uw	4994	3	enhancement	enhancement	NN
cord-001835-0s7ok4uw	4994	4	of	of	IN
cord-001835-0s7ok4uw	4994	5	the	the	DT
cord-001835-0s7ok4uw	4994	6	terminase	terminase	NN
cord-001835-0s7ok4uw	4994	7	-	-	HYPH
cord-001835-0s7ok4uw	4994	8	mediated	mediate	VBN
cord-001835-0s7ok4uw	4994	9	cleavage	cleavage	NN
cord-001835-0s7ok4uw	4994	10	of	of	IN
cord-001835-0s7ok4uw	4994	11	the	the	DT
cord-001835-0s7ok4uw	4994	12	phage	phage	NN
cord-001835-0s7ok4uw	4994	13	cos	cos	IN
cord-001835-0s7ok4uw	4994	14	site	site	NN
cord-001835-0s7ok4uw	4994	15	requires	require	VBZ
cord-001835-0s7ok4uw	4994	16	the	the	DT
cord-001835-0s7ok4uw	4994	17	presence	presence	NN
cord-001835-0s7ok4uw	4994	18	of	of	IN
cord-001835-0s7ok4uw	4994	19	an	an	DT
cord-001835-0s7ok4uw	4994	20	intact	intact	JJ
cord-001835-0s7ok4uw	4994	21	HNH	HNH	NNP
cord-001835-0s7ok4uw	4994	22	motif	motif	NN
cord-001835-0s7ok4uw	4994	23	in	in	IN
cord-001835-0s7ok4uw	4994	24	gp74	gp74	NN
cord-001835-0s7ok4uw	4994	25	.	.	.
cord-001835-0s7ok4uw	4995	1	Mutation	mutation	NN
cord-001835-0s7ok4uw	4995	2	of	of	IN
cord-001835-0s7ok4uw	4995	3	the	the	DT
cord-001835-0s7ok4uw	4995	4	canonical	canonical	JJ
cord-001835-0s7ok4uw	4995	5	metal	metal	NN
cord-001835-0s7ok4uw	4995	6	binding	bind	VBG
cord-001835-0s7ok4uw	4995	7	His	-PRON-	PRP$
cord-001835-0s7ok4uw	4995	8	in	in	IN
cord-001835-0s7ok4uw	4995	9	the	the	DT
cord-001835-0s7ok4uw	4995	10	HNH	HNH	NNP
cord-001835-0s7ok4uw	4995	11	motif	motif	NN
cord-001835-0s7ok4uw	4996	1	abrogates	abrogate	VBZ
cord-001835-0s7ok4uw	4996	2	gp74	gp74	NNP
cord-001835-0s7ok4uw	4996	3	mediated	mediate	VBN
cord-001835-0s7ok4uw	4996	4	-	-	HYPH
cord-001835-0s7ok4uw	4996	5	terminase	terminase	NN
cord-001835-0s7ok4uw	4996	6	activity	activity	NN
cord-001835-0s7ok4uw	4996	7	.	.	.
cord-001835-0s7ok4uw	4997	1	Although	although	IN
cord-001835-0s7ok4uw	4997	2	phages	phage	NNS
cord-001835-0s7ok4uw	4997	3	are	be	VBP
cord-001835-0s7ok4uw	4997	4	widely	widely	RB
cord-001835-0s7ok4uw	4997	5	studied	study	VBN
cord-001835-0s7ok4uw	4997	6	,	,	,
cord-001835-0s7ok4uw	4997	7	there	there	EX
cord-001835-0s7ok4uw	4997	8	is	be	VBZ
cord-001835-0s7ok4uw	4997	9	no	no	DT
cord-001835-0s7ok4uw	4997	10	definitive	definitive	JJ
cord-001835-0s7ok4uw	4997	11	structural	structural	JJ
cord-001835-0s7ok4uw	4997	12	or	or	CC
cord-001835-0s7ok4uw	4997	13	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	4997	14	evidence	evidence	NN
cord-001835-0s7ok4uw	4997	15	as	as	IN
cord-001835-0s7ok4uw	4997	16	to	to	IN
cord-001835-0s7ok4uw	4997	17	how	how	WRB
cord-001835-0s7ok4uw	4997	18	the	the	DT
cord-001835-0s7ok4uw	4997	19	HNH	HNH	NNP
cord-001835-0s7ok4uw	4997	20	endonuclease	endonuclease	NN
cord-001835-0s7ok4uw	4997	21	within	within	IN
cord-001835-0s7ok4uw	4997	22	gp74	gp74	NN
cord-001835-0s7ok4uw	4997	23	functionally	functionally	RB
cord-001835-0s7ok4uw	4997	24	interacts	interact	VBZ
cord-001835-0s7ok4uw	4997	25	with	with	IN
cord-001835-0s7ok4uw	4997	26	the	the	DT
cord-001835-0s7ok4uw	4997	27	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	4997	28	terminase	terminase	NN
cord-001835-0s7ok4uw	4997	29	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4997	30	to	to	TO
cord-001835-0s7ok4uw	4997	31	facilitate	facilitate	VB
cord-001835-0s7ok4uw	4997	32	phage	phage	NN
cord-001835-0s7ok4uw	4997	33	morphogenesis	morphogenesis	NN
cord-001835-0s7ok4uw	4997	34	.	.	.
cord-001835-0s7ok4uw	4998	1	Previous	previous	JJ
cord-001835-0s7ok4uw	4998	2	work	work	NN
cord-001835-0s7ok4uw	4998	3	on	on	IN
cord-001835-0s7ok4uw	4998	4	HNHcontaining	hnhcontaine	VBG
cord-001835-0s7ok4uw	4998	5	bacteriophage	bacteriophage	NN
cord-001835-0s7ok4uw	4998	6	proteins	protein	NNS
cord-001835-0s7ok4uw	4998	7	does	do	VBZ
cord-001835-0s7ok4uw	4998	8	not	not	RB
cord-001835-0s7ok4uw	4998	9	address	address	VB
cord-001835-0s7ok4uw	4998	10	explicitly	explicitly	RB
cord-001835-0s7ok4uw	4998	11	how	how	WRB
cord-001835-0s7ok4uw	4998	12	the	the	DT
cord-001835-0s7ok4uw	4998	13	requirement	requirement	NN
cord-001835-0s7ok4uw	4998	14	for	for	IN
cord-001835-0s7ok4uw	4998	15	divalent	divalent	JJ
cord-001835-0s7ok4uw	4998	16	metal	metal	NN
cord-001835-0s7ok4uw	4998	17	binding	bind	VBG
cord-001835-0s7ok4uw	4998	18	at	at	IN
cord-001835-0s7ok4uw	4998	19	the	the	DT
cord-001835-0s7ok4uw	4998	20	HNH	HNH	NNP
cord-001835-0s7ok4uw	4998	21	endonuclease	endonuclease	NN
cord-001835-0s7ok4uw	4998	22	site	site	NN
cord-001835-0s7ok4uw	4998	23	induces	induce	VBZ
cord-001835-0s7ok4uw	4998	24	interaction	interaction	NN
cord-001835-0s7ok4uw	4998	25	with	with	IN
cord-001835-0s7ok4uw	4998	26	the	the	DT
cord-001835-0s7ok4uw	4998	27	terminase	terminase	NN
cord-001835-0s7ok4uw	4998	28	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	4998	29	that	that	WDT
cord-001835-0s7ok4uw	4998	30	are	be	VBP
cord-001835-0s7ok4uw	4998	31	so	so	RB
cord-001835-0s7ok4uw	4998	32	crucial	crucial	JJ
cord-001835-0s7ok4uw	4998	33	for	for	IN
cord-001835-0s7ok4uw	4998	34	phage	phage	NN
cord-001835-0s7ok4uw	4998	35	DNA	dna	NN
cord-001835-0s7ok4uw	4998	36	packaging	packaging	NN
cord-001835-0s7ok4uw	4998	37	during	during	IN
cord-001835-0s7ok4uw	4998	38	morphogenesis	morphogenesis	NN
cord-001835-0s7ok4uw	4998	39	(	(	-LRB-
cord-001835-0s7ok4uw	4998	40	4	4	CD
cord-001835-0s7ok4uw	4998	41	,	,	,
cord-001835-0s7ok4uw	4998	42	5	5	CD
cord-001835-0s7ok4uw	4998	43	)	)	-RRB-
cord-001835-0s7ok4uw	4998	44	.	.	.
cord-001835-0s7ok4uw	4999	1	In	in	IN
cord-001835-0s7ok4uw	4999	2	addition	addition	NN
cord-001835-0s7ok4uw	4999	3	,	,	,
cord-001835-0s7ok4uw	4999	4	gp74	gp74	NNP
cord-001835-0s7ok4uw	4999	5	possesses	possess	VBZ
cord-001835-0s7ok4uw	4999	6	no	no	DT
cord-001835-0s7ok4uw	4999	7	sequence	sequence	NN
cord-001835-0s7ok4uw	4999	8	similarity	similarity	NN
cord-001835-0s7ok4uw	4999	9	to	to	IN
cord-001835-0s7ok4uw	4999	10	HNH	HNH	NNP
cord-001835-0s7ok4uw	4999	11	proteins	protein	NNS
cord-001835-0s7ok4uw	4999	12	for	for	IN
cord-001835-0s7ok4uw	4999	13	which	which	WDT
cord-001835-0s7ok4uw	4999	14	the	the	DT
cord-001835-0s7ok4uw	4999	15	structure	structure	NN
cord-001835-0s7ok4uw	4999	16	has	have	VBZ
cord-001835-0s7ok4uw	4999	17	been	be	VBN
cord-001835-0s7ok4uw	4999	18	determined	determine	VBN
cord-001835-0s7ok4uw	4999	19	(	(	-LRB-
cord-001835-0s7ok4uw	4999	20	3	3	CD
cord-001835-0s7ok4uw	4999	21	)	)	-RRB-
cord-001835-0s7ok4uw	4999	22	,	,	,
cord-001835-0s7ok4uw	4999	23	making	make	VBG
cord-001835-0s7ok4uw	4999	24	structural	structural	JJ
cord-001835-0s7ok4uw	4999	25	studies	study	NNS
cord-001835-0s7ok4uw	4999	26	of	of	IN
cord-001835-0s7ok4uw	4999	27	gp74	gp74	NN
cord-001835-0s7ok4uw	4999	28	necessary	necessary	JJ
cord-001835-0s7ok4uw	4999	29	.	.	.
cord-001835-0s7ok4uw	5000	1	Toward	toward	IN
cord-001835-0s7ok4uw	5000	2	these	these	DT
cord-001835-0s7ok4uw	5000	3	ends	end	NNS
cord-001835-0s7ok4uw	5000	4	,	,	,
cord-001835-0s7ok4uw	5000	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	5000	6	use	use	VBP
cord-001835-0s7ok4uw	5000	7	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	5000	8	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	5000	9	resonance	resonance	NN
cord-001835-0s7ok4uw	5000	10	(	(	-LRB-
cord-001835-0s7ok4uw	5000	11	NMR	NMR	NNP
cord-001835-0s7ok4uw	5000	12	)	)	-RRB-
cord-001835-0s7ok4uw	5000	13	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	5000	14	to	to	TO
cord-001835-0s7ok4uw	5000	15	probe	probe	VB
cord-001835-0s7ok4uw	5000	16	metal	metal	NN
cord-001835-0s7ok4uw	5000	17	and	and	CC
cord-001835-0s7ok4uw	5000	18	terminase	terminase	NN
cord-001835-0s7ok4uw	5000	19	binding	binding	NN
cord-001835-0s7ok4uw	5000	20	of	of	IN
cord-001835-0s7ok4uw	5000	21	gp74	gp74	NN
cord-001835-0s7ok4uw	5000	22	in	in	IN
cord-001835-0s7ok4uw	5000	23	the	the	DT
cord-001835-0s7ok4uw	5000	24	wild	wild	JJ
cord-001835-0s7ok4uw	5000	25	type	type	NN
cord-001835-0s7ok4uw	5000	26	state	state	NN
cord-001835-0s7ok4uw	5000	27	and	and	CC
cord-001835-0s7ok4uw	5000	28	bearing	bearing	NN
cord-001835-0s7ok4uw	5000	29	metal	metal	NN
cord-001835-0s7ok4uw	5000	30	binding	binding	NN
cord-001835-0s7ok4uw	5000	31	mutations	mutation	NNS
cord-001835-0s7ok4uw	5000	32	.	.	.
cord-001835-0s7ok4uw	5001	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5001	2	also	also	RB
cord-001835-0s7ok4uw	5001	3	report	report	VBP
cord-001835-0s7ok4uw	5001	4	backbone	backbone	NN
cord-001835-0s7ok4uw	5001	5	resonance	resonance	NN
cord-001835-0s7ok4uw	5001	6	assignment	assignment	NN
cord-001835-0s7ok4uw	5001	7	of	of	IN
cord-001835-0s7ok4uw	5001	8	gp74	gp74	NN
cord-001835-0s7ok4uw	5001	9	.	.	.
cord-001835-0s7ok4uw	5002	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	5002	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	5002	3	studies	study	NNS
cord-001835-0s7ok4uw	5002	4	have	have	VBP
cord-001835-0s7ok4uw	5002	5	elucidated	elucidate	VBN
cord-001835-0s7ok4uw	5002	6	residues	residue	NNS
cord-001835-0s7ok4uw	5002	7	within	within	IN
cord-001835-0s7ok4uw	5002	8	gp74	gp74	NN
cord-001835-0s7ok4uw	5002	9	required	require	VBN
cord-001835-0s7ok4uw	5002	10	for	for	IN
cord-001835-0s7ok4uw	5002	11	metal	metal	NN
cord-001835-0s7ok4uw	5002	12	binding	binding	NN
cord-001835-0s7ok4uw	5002	13	and	and	CC
cord-001835-0s7ok4uw	5002	14	terminase	terminase	NN
cord-001835-0s7ok4uw	5002	15	activity	activity	NN
cord-001835-0s7ok4uw	5002	16	.	.	.
cord-001835-0s7ok4uw	5003	1	These	these	DT
cord-001835-0s7ok4uw	5003	2	data	datum	NNS
cord-001835-0s7ok4uw	5003	3	are	be	VBP
cord-001835-0s7ok4uw	5003	4	being	be	VBG
cord-001835-0s7ok4uw	5003	5	used	use	VBN
cord-001835-0s7ok4uw	5003	6	to	to	TO
cord-001835-0s7ok4uw	5003	7	assess	assess	VB
cord-001835-0s7ok4uw	5003	8	the	the	DT
cord-001835-0s7ok4uw	5003	9	role	role	NN
cord-001835-0s7ok4uw	5003	10	of	of	IN
cord-001835-0s7ok4uw	5003	11	specific	specific	JJ
cord-001835-0s7ok4uw	5003	12	gp74	gp74	NN
cord-001835-0s7ok4uw	5003	13	residues	residue	NNS
cord-001835-0s7ok4uw	5003	14	in	in	IN
cord-001835-0s7ok4uw	5003	15	phage	phage	NN
cord-001835-0s7ok4uw	5003	16	morphogenesis	morphogenesis	NN
cord-001835-0s7ok4uw	5003	17	.	.	.
cord-001835-0s7ok4uw	5004	1	Together	together	RB
cord-001835-0s7ok4uw	5004	2	,	,	,
cord-001835-0s7ok4uw	5004	3	this	this	DT
cord-001835-0s7ok4uw	5004	4	work	work	NN
cord-001835-0s7ok4uw	5004	5	will	will	MD
cord-001835-0s7ok4uw	5004	6	identify	identify	VB
cord-001835-0s7ok4uw	5004	7	the	the	DT
cord-001835-0s7ok4uw	5004	8	enigmatic	enigmatic	JJ
cord-001835-0s7ok4uw	5004	9	role	role	NN
cord-001835-0s7ok4uw	5004	10	describing	describe	VBG
cord-001835-0s7ok4uw	5004	11	how	how	WRB
cord-001835-0s7ok4uw	5004	12	metal	metal	NN
cord-001835-0s7ok4uw	5004	13	binding	bind	VBG
cord-001835-0s7ok4uw	5004	14	in	in	IN
cord-001835-0s7ok4uw	5004	15	HNH	HNH	NNP
cord-001835-0s7ok4uw	5004	16	endonucleases	endonuclease	NNS
cord-001835-0s7ok4uw	5004	17	is	be	VBZ
cord-001835-0s7ok4uw	5004	18	crucial	crucial	JJ
cord-001835-0s7ok4uw	5004	19	in	in	IN
cord-001835-0s7ok4uw	5004	20	the	the	DT
cord-001835-0s7ok4uw	5004	21	replication	replication	NN
cord-001835-0s7ok4uw	5004	22	and	and	CC
cord-001835-0s7ok4uw	5004	23	morphogenesis	morphogenesis	NN
cord-001835-0s7ok4uw	5004	24	of	of	IN
cord-001835-0s7ok4uw	5004	25	phages	phage	NNS
cord-001835-0s7ok4uw	5004	26	.	.	.
cord-001835-0s7ok4uw	5005	1	Meat	meat	NN
cord-001835-0s7ok4uw	5005	2	production	production	NN
cord-001835-0s7ok4uw	5005	3	from	from	IN
cord-001835-0s7ok4uw	5005	4	pigs	pig	NNS
cord-001835-0s7ok4uw	5005	5	for	for	IN
cord-001835-0s7ok4uw	5005	6	human	human	JJ
cord-001835-0s7ok4uw	5005	7	consumption	consumption	NN
cord-001835-0s7ok4uw	5005	8	is	be	VBZ
cord-001835-0s7ok4uw	5005	9	a	a	DT
cord-001835-0s7ok4uw	5005	10	resource	resource	NN
cord-001835-0s7ok4uw	5005	11	heavy	heavy	JJ
cord-001835-0s7ok4uw	5005	12	process	process	NN
cord-001835-0s7ok4uw	5005	13	,	,	,
cord-001835-0s7ok4uw	5005	14	indeed	indeed	RB
cord-001835-0s7ok4uw	5005	15	every	every	DT
cord-001835-0s7ok4uw	5005	16	part	part	NN
cord-001835-0s7ok4uw	5005	17	of	of	IN
cord-001835-0s7ok4uw	5005	18	the	the	DT
cord-001835-0s7ok4uw	5005	19	animal	animal	NN
cord-001835-0s7ok4uw	5005	20	that	that	WDT
cord-001835-0s7ok4uw	5005	21	is	be	VBZ
cord-001835-0s7ok4uw	5005	22	not	not	RB
cord-001835-0s7ok4uw	5005	23	used	use	VBN
cord-001835-0s7ok4uw	5005	24	constitutes	constitute	VBZ
cord-001835-0s7ok4uw	5005	25	a	a	DT
cord-001835-0s7ok4uw	5005	26	protein	protein	NN
cord-001835-0s7ok4uw	5005	27	food	food	NN
cord-001835-0s7ok4uw	5005	28	-	-	HYPH
cord-001835-0s7ok4uw	5005	29	chain	chain	NN
cord-001835-0s7ok4uw	5005	30	loss	loss	NN
cord-001835-0s7ok4uw	5005	31	,	,	,
cord-001835-0s7ok4uw	5005	32	which	which	WDT
cord-001835-0s7ok4uw	5005	33	is	be	VBZ
cord-001835-0s7ok4uw	5005	34	neither	neither	CC
cord-001835-0s7ok4uw	5005	35	economically	economically	RB
cord-001835-0s7ok4uw	5005	36	nor	nor	CC
cord-001835-0s7ok4uw	5005	37	environmentally	environmentally	RB
cord-001835-0s7ok4uw	5005	38	viable	viable	JJ
cord-001835-0s7ok4uw	5005	39	.	.	.
cord-001835-0s7ok4uw	5006	1	The	the	DT
cord-001835-0s7ok4uw	5006	2	goal	goal	NN
cord-001835-0s7ok4uw	5006	3	of	of	IN
cord-001835-0s7ok4uw	5006	4	this	this	DT
cord-001835-0s7ok4uw	5006	5	project	project	NN
cord-001835-0s7ok4uw	5006	6	is	be	VBZ
cord-001835-0s7ok4uw	5006	7	to	to	TO
cord-001835-0s7ok4uw	5006	8	better	well	JJR
cord-001835-0s7ok4uw	5006	9	harness	harness	VB
cord-001835-0s7ok4uw	5006	10	slaughterhouse	slaughterhouse	NN
cord-001835-0s7ok4uw	5006	11	waste	waste	NN
cord-001835-0s7ok4uw	5006	12	such	such	JJ
cord-001835-0s7ok4uw	5006	13	as	as	IN
cord-001835-0s7ok4uw	5006	14	the	the	DT
cord-001835-0s7ok4uw	5006	15	keratin	keratin	JJ
cord-001835-0s7ok4uw	5006	16	rich	rich	JJ
cord-001835-0s7ok4uw	5006	17	pig	pig	NN
cord-001835-0s7ok4uw	5006	18	bristles	bristle	NNS
cord-001835-0s7ok4uw	5006	19	and	and	CC
cord-001835-0s7ok4uw	5006	20	nails	nail	NNS
cord-001835-0s7ok4uw	5006	21	through	through	IN
cord-001835-0s7ok4uw	5006	22	microbial	microbial	JJ
cord-001835-0s7ok4uw	5006	23	conversion	conversion	NN
cord-001835-0s7ok4uw	5006	24	.	.	.
cord-001835-0s7ok4uw	5007	1	Instead	instead	RB
cord-001835-0s7ok4uw	5007	2	of	of	IN
cord-001835-0s7ok4uw	5007	3	using	use	VBG
cord-001835-0s7ok4uw	5007	4	identified	identify	VBN
cord-001835-0s7ok4uw	5007	5	single	single	JJ
cord-001835-0s7ok4uw	5007	6	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	5007	7	,	,	,
cord-001835-0s7ok4uw	5007	8	it	-PRON-	PRP
cord-001835-0s7ok4uw	5007	9	is	be	VBZ
cord-001835-0s7ok4uw	5007	10	the	the	DT
cord-001835-0s7ok4uw	5007	11	goal	goal	NN
cord-001835-0s7ok4uw	5007	12	to	to	TO
cord-001835-0s7ok4uw	5007	13	define	define	VB
cord-001835-0s7ok4uw	5007	14	microbial	microbial	JJ
cord-001835-0s7ok4uw	5007	15	consortia	consortium	NNS
cord-001835-0s7ok4uw	5007	16	where	where	WRB
cord-001835-0s7ok4uw	5007	17	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	5007	18	synergistically	synergistically	RB
cord-001835-0s7ok4uw	5007	19	show	show	VBP
cord-001835-0s7ok4uw	5007	20	the	the	DT
cord-001835-0s7ok4uw	5007	21	ability	ability	NN
cord-001835-0s7ok4uw	5007	22	of	of	IN
cord-001835-0s7ok4uw	5007	23	efficient	efficient	JJ
cord-001835-0s7ok4uw	5007	24	keratin	keratin	NN
cord-001835-0s7ok4uw	5007	25	degradation	degradation	NN
cord-001835-0s7ok4uw	5007	26	/	/	SYM
cord-001835-0s7ok4uw	5007	27	conversion	conversion	NN
cord-001835-0s7ok4uw	5007	28	.	.	.
cord-001835-0s7ok4uw	5008	1	Candidate	candidate	NN
cord-001835-0s7ok4uw	5008	2	consortia	consortium	NNS
cord-001835-0s7ok4uw	5008	3	have	have	VBP
cord-001835-0s7ok4uw	5008	4	been	be	VBN
cord-001835-0s7ok4uw	5008	5	obtained	obtain	VBN
cord-001835-0s7ok4uw	5008	6	by	by	IN
cord-001835-0s7ok4uw	5008	7	selecting	select	VBG
cord-001835-0s7ok4uw	5008	8	for	for	IN
cord-001835-0s7ok4uw	5008	9	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	5008	10	growing	grow	VBG
cord-001835-0s7ok4uw	5008	11	on	on	IN
cord-001835-0s7ok4uw	5008	12	enriched	enriched	JJ
cord-001835-0s7ok4uw	5008	13	media	medium	NNS
cord-001835-0s7ok4uw	5008	14	that	that	WDT
cord-001835-0s7ok4uw	5008	15	contains	contain	VBZ
cord-001835-0s7ok4uw	5008	16	milled	mill	VBN
cord-001835-0s7ok4uw	5008	17	pig	pig	NN
cord-001835-0s7ok4uw	5008	18	bristles	bristle	NNS
cord-001835-0s7ok4uw	5008	19	as	as	IN
cord-001835-0s7ok4uw	5008	20	sole	sole	JJ
cord-001835-0s7ok4uw	5008	21	carbon	carbon	NN
cord-001835-0s7ok4uw	5008	22	and	and	CC
cord-001835-0s7ok4uw	5008	23	nitrogen	nitrogen	NN
cord-001835-0s7ok4uw	5008	24	source	source	NN
cord-001835-0s7ok4uw	5008	25	.	.	.
cord-001835-0s7ok4uw	5009	1	By	by	IN
cord-001835-0s7ok4uw	5009	2	using	use	VBG
cord-001835-0s7ok4uw	5009	3	mass	mass	NN
cord-001835-0s7ok4uw	5009	4	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	5009	5	and	and	CC
cord-001835-0s7ok4uw	5009	6	various	various	JJ
cord-001835-0s7ok4uw	5009	7	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5009	8	analyses	analysis	NNS
cord-001835-0s7ok4uw	5009	9	to	to	TO
cord-001835-0s7ok4uw	5009	10	investigate	investigate	VB
cord-001835-0s7ok4uw	5009	11	keratinolytic	keratinolytic	JJ
cord-001835-0s7ok4uw	5009	12	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5009	13	,	,	,
cord-001835-0s7ok4uw	5009	14	methods	method	NNS
cord-001835-0s7ok4uw	5009	15	will	will	MD
cord-001835-0s7ok4uw	5009	16	be	be	VB
cord-001835-0s7ok4uw	5009	17	established	establish	VBN
cord-001835-0s7ok4uw	5009	18	for	for	IN
cord-001835-0s7ok4uw	5009	19	identifying	identify	VBG
cord-001835-0s7ok4uw	5009	20	and	and	CC
cord-001835-0s7ok4uw	5009	21	characterizing	characterize	VBG
cord-001835-0s7ok4uw	5009	22	suitable	suitable	JJ
cord-001835-0s7ok4uw	5009	23	consortia	consortium	NNS
cord-001835-0s7ok4uw	5009	24	.	.	.
cord-001835-0s7ok4uw	5010	1	Protein	protein	NN
cord-001835-0s7ok4uw	5010	2	families	family	NNS
cord-001835-0s7ok4uw	5010	3	likely	likely	JJ
cord-001835-0s7ok4uw	5010	4	to	to	TO
cord-001835-0s7ok4uw	5010	5	be	be	VB
cord-001835-0s7ok4uw	5010	6	involved	involve	VBN
cord-001835-0s7ok4uw	5010	7	are	be	VBP
cord-001835-0s7ok4uw	5010	8	keratinases	keratinase	NNS
cord-001835-0s7ok4uw	5010	9	,	,	,
cord-001835-0s7ok4uw	5010	10	which	which	WDT
cord-001835-0s7ok4uw	5010	11	are	be	VBP
cord-001835-0s7ok4uw	5010	12	specialized	specialize	VBN
cord-001835-0s7ok4uw	5010	13	proteases	protease	NNS
cord-001835-0s7ok4uw	5010	14	including	include	VBG
cord-001835-0s7ok4uw	5010	15	serine	serine	NN
cord-001835-0s7ok4uw	5010	16	,	,	,
cord-001835-0s7ok4uw	5010	17	cysteine	cysteine	NN
cord-001835-0s7ok4uw	5010	18	and	and	CC
cord-001835-0s7ok4uw	5010	19	metallo	metallo	NN
cord-001835-0s7ok4uw	5010	20	proteases	protease	NNS
cord-001835-0s7ok4uw	5010	21	,	,	,
cord-001835-0s7ok4uw	5010	22	as	as	RB
cord-001835-0s7ok4uw	5010	23	well	well	RB
cord-001835-0s7ok4uw	5010	24	as	as	IN
cord-001835-0s7ok4uw	5010	25	systems	system	NNS
cord-001835-0s7ok4uw	5010	26	capable	capable	JJ
cord-001835-0s7ok4uw	5010	27	of	of	IN
cord-001835-0s7ok4uw	5010	28	reducing	reduce	VBG
cord-001835-0s7ok4uw	5010	29	or	or	CC
cord-001835-0s7ok4uw	5010	30	otherwise	otherwise	RB
cord-001835-0s7ok4uw	5010	31	breaking	break	VBG
cord-001835-0s7ok4uw	5010	32	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	5010	33	bonds	bond	NNS
cord-001835-0s7ok4uw	5010	34	which	which	WDT
cord-001835-0s7ok4uw	5010	35	are	be	VBP
cord-001835-0s7ok4uw	5010	36	highly	highly	RB
cord-001835-0s7ok4uw	5010	37	abundant	abundant	JJ
cord-001835-0s7ok4uw	5010	38	in	in	IN
cord-001835-0s7ok4uw	5010	39	hair	hair	NN
cord-001835-0s7ok4uw	5010	40	and	and	CC
cord-001835-0s7ok4uw	5010	41	nails	nail	NNS
cord-001835-0s7ok4uw	5010	42	.	.	.
cord-001835-0s7ok4uw	5011	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	5011	2	,	,	,
cord-001835-0s7ok4uw	5011	3	interactions	interaction	NNS
cord-001835-0s7ok4uw	5011	4	and	and	CC
cord-001835-0s7ok4uw	5011	5	symbiosis	symbiosis	NN
cord-001835-0s7ok4uw	5011	6	of	of	IN
cord-001835-0s7ok4uw	5011	7	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	5011	8	in	in	IN
cord-001835-0s7ok4uw	5011	9	a	a	DT
cord-001835-0s7ok4uw	5011	10	consortium	consortium	NN
cord-001835-0s7ok4uw	5011	11	will	will	MD
cord-001835-0s7ok4uw	5011	12	be	be	VB
cord-001835-0s7ok4uw	5011	13	investigated	investigate	VBN
cord-001835-0s7ok4uw	5011	14	at	at	IN
cord-001835-0s7ok4uw	5011	15	the	the	DT
cord-001835-0s7ok4uw	5011	16	meta	meta	NNP
cord-001835-0s7ok4uw	5011	17	-	-	HYPH
cord-001835-0s7ok4uw	5011	18	proteomics	proteomic	NNS
cord-001835-0s7ok4uw	5011	19	level	level	NN
cord-001835-0s7ok4uw	5011	20	.	.	.
cord-001835-0s7ok4uw	5012	1	The	the	DT
cord-001835-0s7ok4uw	5012	2	project	project	NN
cord-001835-0s7ok4uw	5012	3	will	will	MD
cord-001835-0s7ok4uw	5012	4	lead	lead	VB
cord-001835-0s7ok4uw	5012	5	to	to	IN
cord-001835-0s7ok4uw	5012	6	development	development	NN
cord-001835-0s7ok4uw	5012	7	of	of	IN
cord-001835-0s7ok4uw	5012	8	biotechnological	biotechnological	JJ
cord-001835-0s7ok4uw	5012	9	degradation	degradation	NN
cord-001835-0s7ok4uw	5012	10	of	of	IN
cord-001835-0s7ok4uw	5012	11	keratin	keratin	NN
cord-001835-0s7ok4uw	5012	12	rich	rich	JJ
cord-001835-0s7ok4uw	5012	13	fibers	fiber	NNS
cord-001835-0s7ok4uw	5012	14	,	,	,
cord-001835-0s7ok4uw	5012	15	and	and	CC
cord-001835-0s7ok4uw	5012	16	provide	provide	VB
cord-001835-0s7ok4uw	5012	17	new	new	JJ
cord-001835-0s7ok4uw	5012	18	insights	insight	NNS
cord-001835-0s7ok4uw	5012	19	into	into	IN
cord-001835-0s7ok4uw	5012	20	functional	functional	JJ
cord-001835-0s7ok4uw	5012	21	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	5012	22	and	and	CC
cord-001835-0s7ok4uw	5012	23	efficacy	efficacy	NN
cord-001835-0s7ok4uw	5012	24	of	of	IN
cord-001835-0s7ok4uw	5012	25	microbial	microbial	JJ
cord-001835-0s7ok4uw	5012	26	consortia	consortium	NNS
cord-001835-0s7ok4uw	5012	27	.	.	.
cord-001835-0s7ok4uw	5013	1	A	a	DT
cord-001835-0s7ok4uw	5013	2	comprehensive	comprehensive	JJ
cord-001835-0s7ok4uw	5013	3	protein	protein	NN
cord-001835-0s7ok4uw	5013	4	domain	domain	NN
cord-001835-0s7ok4uw	5013	5	analysis	analysis	NN
cord-001835-0s7ok4uw	5013	6	to	to	TO
cord-001835-0s7ok4uw	5013	7	map	map	VB
cord-001835-0s7ok4uw	5013	8	cancer	cancer	NN
cord-001835-0s7ok4uw	5013	9	-	-	HYPH
cord-001835-0s7ok4uw	5013	10	type	type	NN
cord-001835-0s7ok4uw	5013	11	-	-	HYPH
cord-001835-0s7ok4uw	5013	12	specific	specific	JJ
cord-001835-0s7ok4uw	5013	13	somatic	somatic	JJ
cord-001835-0s7ok4uw	5013	14	mutations	mutation	NNS
cord-001835-0s7ok4uw	5014	1	Interpretation	interpretation	NN
cord-001835-0s7ok4uw	5014	2	of	of	IN
cord-001835-0s7ok4uw	5014	3	the	the	DT
cord-001835-0s7ok4uw	5014	4	genome	genome	NN
cord-001835-0s7ok4uw	5014	5	-	-	HYPH
cord-001835-0s7ok4uw	5014	6	wide	wide	JJ
cord-001835-0s7ok4uw	5014	7	association	association	NN
cord-001835-0s7ok4uw	5014	8	studies	study	NNS
cord-001835-0s7ok4uw	5014	9	(	(	-LRB-
cord-001835-0s7ok4uw	5014	10	GWAS	GWAS	NNP
cord-001835-0s7ok4uw	5014	11	)	)	-RRB-
cord-001835-0s7ok4uw	5014	12	of	of	IN
cord-001835-0s7ok4uw	5014	13	cancer	cancer	NN
cord-001835-0s7ok4uw	5014	14	patients	patient	NNS
cord-001835-0s7ok4uw	5014	15	to	to	TO
cord-001835-0s7ok4uw	5014	16	find	find	VB
cord-001835-0s7ok4uw	5014	17	cancer	cancer	NN
cord-001835-0s7ok4uw	5014	18	-	-	HYPH
cord-001835-0s7ok4uw	5014	19	typespecific	typespecific	NN
cord-001835-0s7ok4uw	5014	20	biomarker	biomarker	NN
cord-001835-0s7ok4uw	5014	21	is	be	VBZ
cord-001835-0s7ok4uw	5014	22	challenging	challenge	VBG
cord-001835-0s7ok4uw	5014	23	due	due	IN
cord-001835-0s7ok4uw	5014	24	to	to	IN
cord-001835-0s7ok4uw	5014	25	the	the	DT
cord-001835-0s7ok4uw	5014	26	mutational	mutational	JJ
cord-001835-0s7ok4uw	5014	27	heterogeneity	heterogeneity	NN
cord-001835-0s7ok4uw	5014	28	of	of	IN
cord-001835-0s7ok4uw	5014	29	cancer	cancer	NN
cord-001835-0s7ok4uw	5014	30	types	type	NNS
cord-001835-0s7ok4uw	5014	31	.	.	.
cord-001835-0s7ok4uw	5015	1	Network	network	NN
cord-001835-0s7ok4uw	5015	2	approaches	approach	NNS
cord-001835-0s7ok4uw	5015	3	to	to	TO
cord-001835-0s7ok4uw	5015	4	find	find	VB
cord-001835-0s7ok4uw	5015	5	cancer	cancer	NN
cord-001835-0s7ok4uw	5015	6	-	-	HYPH
cord-001835-0s7ok4uw	5015	7	type	type	NN
cord-001835-0s7ok4uw	5015	8	-	-	HYPH
cord-001835-0s7ok4uw	5015	9	specific	specific	JJ
cord-001835-0s7ok4uw	5015	10	variants	variant	NNS
cord-001835-0s7ok4uw	5015	11	and	and	CC
cord-001835-0s7ok4uw	5015	12	biological	biological	JJ
cord-001835-0s7ok4uw	5015	13	pathways	pathway	NNS
cord-001835-0s7ok4uw	5015	14	are	be	VBP
cord-001835-0s7ok4uw	5015	15	increasing	increase	VBG
cord-001835-0s7ok4uw	5015	16	since	since	IN
cord-001835-0s7ok4uw	5015	17	genes	gene	NNS
cord-001835-0s7ok4uw	5015	18	tend	tend	VBP
cord-001835-0s7ok4uw	5015	19	to	to	TO
cord-001835-0s7ok4uw	5015	20	act	act	VB
cord-001835-0s7ok4uw	5015	21	together	together	RB
cord-001835-0s7ok4uw	5015	22	to	to	TO
cord-001835-0s7ok4uw	5015	23	display	display	VB
cord-001835-0s7ok4uw	5015	24	phenotypic	phenotypic	NNS
cord-001835-0s7ok4uw	5015	25	or	or	CC
cord-001835-0s7ok4uw	5015	26	disease	disease	NN
cord-001835-0s7ok4uw	5015	27	outcomes	outcome	NNS
cord-001835-0s7ok4uw	5015	28	.	.	.
cord-001835-0s7ok4uw	5016	1	Phenotype	phenotype	NN
cord-001835-0s7ok4uw	5016	2	similarity	similarity	NN
cord-001835-0s7ok4uw	5016	3	has	have	VBZ
cord-001835-0s7ok4uw	5016	4	proven	prove	VBN
cord-001835-0s7ok4uw	5016	5	to	to	TO
cord-001835-0s7ok4uw	5016	6	reflect	reflect	VB
cord-001835-0s7ok4uw	5016	7	the	the	DT
cord-001835-0s7ok4uw	5016	8	relationship	relationship	NN
cord-001835-0s7ok4uw	5016	9	of	of	IN
cord-001835-0s7ok4uw	5016	10	functionally	functionally	RB
cord-001835-0s7ok4uw	5016	11	related	relate	VBN
cord-001835-0s7ok4uw	5016	12	genes	gene	NNS
cord-001835-0s7ok4uw	5016	13	.	.	.
cord-001835-0s7ok4uw	5017	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5017	2	applied	apply	VBD
cord-001835-0s7ok4uw	5017	3	phenotype	phenotype	NN
cord-001835-0s7ok4uw	5017	4	similarities	similarity	NNS
cord-001835-0s7ok4uw	5017	5	between	between	IN
cord-001835-0s7ok4uw	5017	6	various	various	JJ
cord-001835-0s7ok4uw	5017	7	diseases	disease	NNS
cord-001835-0s7ok4uw	5017	8	for	for	IN
cord-001835-0s7ok4uw	5017	9	expanding	expand	VBG
cord-001835-0s7ok4uw	5017	10	molecular	molecular	JJ
cord-001835-0s7ok4uw	5017	11	connections	connection	NNS
cord-001835-0s7ok4uw	5017	12	of	of	IN
cord-001835-0s7ok4uw	5017	13	cancer	cancer	NN
cord-001835-0s7ok4uw	5017	14	-	-	HYPH
cord-001835-0s7ok4uw	5017	15	type	type	NN
cord-001835-0s7ok4uw	5017	16	-	-	HYPH
cord-001835-0s7ok4uw	5017	17	specific	specific	JJ
cord-001835-0s7ok4uw	5017	18	variants	variant	NNS
cord-001835-0s7ok4uw	5017	19	to	to	TO
cord-001835-0s7ok4uw	5017	20	discover	discover	VB
cord-001835-0s7ok4uw	5017	21	cancer	cancer	NN
cord-001835-0s7ok4uw	5017	22	-	-	HYPH
cord-001835-0s7ok4uw	5017	23	type	type	NN
cord-001835-0s7ok4uw	5017	24	-	-	HYPH
cord-001835-0s7ok4uw	5017	25	specific	specific	JJ
cord-001835-0s7ok4uw	5017	26	modules	module	NNS
cord-001835-0s7ok4uw	5017	27	.	.	.
cord-001835-0s7ok4uw	5018	1	Specifically	specifically	RB
cord-001835-0s7ok4uw	5018	2	,	,	,
cord-001835-0s7ok4uw	5018	3	cancer	cancer	NN
cord-001835-0s7ok4uw	5018	4	-	-	HYPH
cord-001835-0s7ok4uw	5018	5	type	type	NN
cord-001835-0s7ok4uw	5018	6	-	-	HYPH
cord-001835-0s7ok4uw	5018	7	specific	specific	JJ
cord-001835-0s7ok4uw	5018	8	variants	variant	NNS
cord-001835-0s7ok4uw	5018	9	of	of	IN
cord-001835-0s7ok4uw	5018	10	7	7	CD
cord-001835-0s7ok4uw	5018	11	cancer	cancer	NN
cord-001835-0s7ok4uw	5018	12	types	type	NNS
cord-001835-0s7ok4uw	5018	13	from	from	IN
cord-001835-0s7ok4uw	5018	14	The	the	DT
cord-001835-0s7ok4uw	5018	15	Cancer	Cancer	NNP
cord-001835-0s7ok4uw	5018	16	Genome	Genome	NNP
cord-001835-0s7ok4uw	5018	17	Atlas	Atlas	NNP
cord-001835-0s7ok4uw	5018	18	(	(	-LRB-
cord-001835-0s7ok4uw	5018	19	TCGA	TCGA	NNP
cord-001835-0s7ok4uw	5018	20	)	)	-RRB-
cord-001835-0s7ok4uw	5018	21	were	be	VBD
cord-001835-0s7ok4uw	5018	22	analyzed	analyze	VBN
cord-001835-0s7ok4uw	5018	23	to	to	TO
cord-001835-0s7ok4uw	5018	24	find	find	VB
cord-001835-0s7ok4uw	5018	25	phenotype	phenotype	NN
cord-001835-0s7ok4uw	5018	26	-	-	HYPH
cord-001835-0s7ok4uw	5018	27	inferred	infer	VBN
cord-001835-0s7ok4uw	5018	28	relationships	relationship	NNS
cord-001835-0s7ok4uw	5018	29	among	among	IN
cord-001835-0s7ok4uw	5018	30	the	the	DT
cord-001835-0s7ok4uw	5018	31	variants	variant	NNS
cord-001835-0s7ok4uw	5018	32	.	.	.
cord-001835-0s7ok4uw	5019	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5019	2	find	find	VBP
cord-001835-0s7ok4uw	5019	3	that	that	IN
cord-001835-0s7ok4uw	5019	4	cancer	cancer	NN
cord-001835-0s7ok4uw	5019	5	variants	variant	NNS
cord-001835-0s7ok4uw	5019	6	that	that	WDT
cord-001835-0s7ok4uw	5019	7	cause	cause	VBP
cord-001835-0s7ok4uw	5019	8	the	the	DT
cord-001835-0s7ok4uw	5019	9	similar	similar	JJ
cord-001835-0s7ok4uw	5019	10	disease	disease	NN
cord-001835-0s7ok4uw	5019	11	phenotypes	phenotype	NNS
cord-001835-0s7ok4uw	5019	12	tend	tend	VBP
cord-001835-0s7ok4uw	5019	13	to	to	TO
cord-001835-0s7ok4uw	5019	14	be	be	VB
cord-001835-0s7ok4uw	5019	15	linked	link	VBN
cord-001835-0s7ok4uw	5019	16	as	as	IN
cord-001835-0s7ok4uw	5019	17	a	a	DT
cord-001835-0s7ok4uw	5019	18	cluster	cluster	NN
cord-001835-0s7ok4uw	5019	19	of	of	IN
cord-001835-0s7ok4uw	5019	20	biological	biological	JJ
cord-001835-0s7ok4uw	5019	21	pathways	pathway	NNS
cord-001835-0s7ok4uw	5019	22	or	or	CC
cord-001835-0s7ok4uw	5019	23	functions	function	NNS
cord-001835-0s7ok4uw	5019	24	.	.	.
cord-001835-0s7ok4uw	5020	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	5020	2	,	,	,
cord-001835-0s7ok4uw	5020	3	cancer	cancer	NN
cord-001835-0s7ok4uw	5020	4	-	-	HYPH
cord-001835-0s7ok4uw	5020	5	type	type	NN
cord-001835-0s7ok4uw	5020	6	-	-	HYPH
cord-001835-0s7ok4uw	5020	7	specific	specific	JJ
cord-001835-0s7ok4uw	5020	8	modules	module	NNS
cord-001835-0s7ok4uw	5020	9	could	could	MD
cord-001835-0s7ok4uw	5020	10	explain	explain	VB
cord-001835-0s7ok4uw	5020	11	the	the	DT
cord-001835-0s7ok4uw	5020	12	underlying	underlie	VBG
cord-001835-0s7ok4uw	5020	13	pathogenicity	pathogenicity	NN
cord-001835-0s7ok4uw	5020	14	of	of	IN
cord-001835-0s7ok4uw	5020	15	specific	specific	JJ
cord-001835-0s7ok4uw	5020	16	symptoms	symptom	NNS
cord-001835-0s7ok4uw	5020	17	which	which	WDT
cord-001835-0s7ok4uw	5020	18	manifest	manifest	VBP
cord-001835-0s7ok4uw	5020	19	in	in	IN
cord-001835-0s7ok4uw	5020	20	particular	particular	JJ
cord-001835-0s7ok4uw	5020	21	cancer	cancer	NN
cord-001835-0s7ok4uw	5020	22	types	type	NNS
cord-001835-0s7ok4uw	5020	23	.	.	.
cord-001835-0s7ok4uw	5021	1	Cancer	cancer	NN
cord-001835-0s7ok4uw	5021	2	-	-	HYPH
cord-001835-0s7ok4uw	5021	3	type	type	NN
cord-001835-0s7ok4uw	5021	4	-	-	HYPH
cord-001835-0s7ok4uw	5021	5	specific	specific	JJ
cord-001835-0s7ok4uw	5021	6	modules	module	NNS
cord-001835-0s7ok4uw	5021	7	and	and	CC
cord-001835-0s7ok4uw	5021	8	pathways	pathway	NNS
cord-001835-0s7ok4uw	5021	9	found	find	VBN
cord-001835-0s7ok4uw	5021	10	from	from	IN
cord-001835-0s7ok4uw	5021	11	phenotype	phenotype	NN
cord-001835-0s7ok4uw	5021	12	similarity	similarity	NN
cord-001835-0s7ok4uw	5021	13	/	/	SYM
cord-001835-0s7ok4uw	5021	14	dissimilarity	dissimilarity	NN
cord-001835-0s7ok4uw	5021	15	based	base	VBN
cord-001835-0s7ok4uw	5021	16	on	on	IN
cord-001835-0s7ok4uw	5021	17	cancer	cancer	NN
cord-001835-0s7ok4uw	5021	18	symptoms	symptom	NNS
cord-001835-0s7ok4uw	5021	19	improved	improve	VBD
cord-001835-0s7ok4uw	5021	20	the	the	DT
cord-001835-0s7ok4uw	5021	21	discrimination	discrimination	NN
cord-001835-0s7ok4uw	5021	22	performance	performance	NN
cord-001835-0s7ok4uw	5021	23	to	to	IN
cord-001835-0s7ok4uw	5021	24	sort	sort	JJ
cord-001835-0s7ok4uw	5021	25	cancer	cancer	NN
cord-001835-0s7ok4uw	5021	26	-	-	HYPH
cord-001835-0s7ok4uw	5021	27	type	type	NN
cord-001835-0s7ok4uw	5021	28	-	-	HYPH
cord-001835-0s7ok4uw	5021	29	specific	specific	JJ
cord-001835-0s7ok4uw	5021	30	variants	variant	NNS
cord-001835-0s7ok4uw	5021	31	to	to	TO
cord-001835-0s7ok4uw	5021	32	accurately	accurately	RB
cord-001835-0s7ok4uw	5021	33	predict	predict	VB
cord-001835-0s7ok4uw	5021	34	patient	patient	JJ
cord-001835-0s7ok4uw	5021	35	groups	group	NNS
cord-001835-0s7ok4uw	5021	36	.	.	.
cord-001835-0s7ok4uw	5022	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	5022	2	method	method	NN
cord-001835-0s7ok4uw	5022	3	will	will	MD
cord-001835-0s7ok4uw	5022	4	be	be	VB
cord-001835-0s7ok4uw	5022	5	further	further	RB
cord-001835-0s7ok4uw	5022	6	developed	develop	VBN
cord-001835-0s7ok4uw	5022	7	to	to	TO
cord-001835-0s7ok4uw	5022	8	find	find	VB
cord-001835-0s7ok4uw	5022	9	genetic	genetic	JJ
cord-001835-0s7ok4uw	5022	10	biomarkers	biomarker	NNS
cord-001835-0s7ok4uw	5022	11	for	for	IN
cord-001835-0s7ok4uw	5022	12	the	the	DT
cord-001835-0s7ok4uw	5022	13	diagnosis	diagnosis	NN
cord-001835-0s7ok4uw	5022	14	or	or	CC
cord-001835-0s7ok4uw	5022	15	prognosis	prognosis	NN
cord-001835-0s7ok4uw	5022	16	of	of	IN
cord-001835-0s7ok4uw	5022	17	specific	specific	JJ
cord-001835-0s7ok4uw	5022	18	cancer	cancer	NN
cord-001835-0s7ok4uw	5022	19	types	type	NNS
cord-001835-0s7ok4uw	5022	20	PK-009	PK-009	NNP
cord-001835-0s7ok4uw	5022	21	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	5022	22	a	a	DT
cord-001835-0s7ok4uw	5022	23	stable	stable	JJ
cord-001835-0s7ok4uw	5022	24	,	,	,
cord-001835-0s7ok4uw	5022	25	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	5022	26	membrane	membrane	NN
cord-001835-0s7ok4uw	5022	27	protein	protein	NN
cord-001835-0s7ok4uw	5022	28	scaffold	scaffold	NN
cord-001835-0s7ok4uw	5022	29	Amanda	Amanda	NNP
cord-001835-0s7ok4uw	5022	30	Duran	Duran	NNP
cord-001835-0s7ok4uw	5022	31	1	1	CD
cord-001835-0s7ok4uw	5023	1	,	,	,
cord-001835-0s7ok4uw	5023	2	Jens	Jens	NNP
cord-001835-0s7ok4uw	5023	3	Meiler	Meiler	NNP
cord-001835-0s7ok4uw	5023	4	1	1	CD
cord-001835-0s7ok4uw	5023	5	1	1	CD
cord-001835-0s7ok4uw	5023	6	Computational	computational	JJ
cord-001835-0s7ok4uw	5023	7	protein	protein	NN
cord-001835-0s7ok4uw	5023	8	engineering	engineering	NN
cord-001835-0s7ok4uw	5023	9	has	have	VBZ
cord-001835-0s7ok4uw	5023	10	the	the	DT
cord-001835-0s7ok4uw	5023	11	potential	potential	NN
cord-001835-0s7ok4uw	5023	12	to	to	TO
cord-001835-0s7ok4uw	5023	13	contribute	contribute	VB
cord-001835-0s7ok4uw	5023	14	to	to	IN
cord-001835-0s7ok4uw	5023	15	various	various	JJ
cord-001835-0s7ok4uw	5023	16	fields	field	NNS
cord-001835-0s7ok4uw	5023	17	including	include	VBG
cord-001835-0s7ok4uw	5023	18	drug	drug	NN
cord-001835-0s7ok4uw	5023	19	design	design	NN
cord-001835-0s7ok4uw	5023	20	,	,	,
cord-001835-0s7ok4uw	5023	21	protein	protein	NN
cord-001835-0s7ok4uw	5023	22	therapeutics	therapeutic	NNS
cord-001835-0s7ok4uw	5023	23	,	,	,
cord-001835-0s7ok4uw	5023	24	and	and	CC
cord-001835-0s7ok4uw	5023	25	materials	material	NNS
cord-001835-0s7ok4uw	5023	26	science	science	NN
cord-001835-0s7ok4uw	5023	27	.	.	.
cord-001835-0s7ok4uw	5024	1	Protein	protein	NN
cord-001835-0s7ok4uw	5024	2	-	-	HYPH
cord-001835-0s7ok4uw	5024	3	ligand	ligand	NN
cord-001835-0s7ok4uw	5024	4	interface	interface	NN
cord-001835-0s7ok4uw	5024	5	design	design	NN
cord-001835-0s7ok4uw	5024	6	and	and	CC
cord-001835-0s7ok4uw	5024	7	the	the	DT
cord-001835-0s7ok4uw	5024	8	construction	construction	NN
cord-001835-0s7ok4uw	5024	9	of	of	IN
cord-001835-0s7ok4uw	5024	10	large	large	JJ
cord-001835-0s7ok4uw	5024	11	,	,	,
cord-001835-0s7ok4uw	5024	12	stable	stable	JJ
cord-001835-0s7ok4uw	5024	13	proteins	protein	NNS
cord-001835-0s7ok4uw	5024	14	rely	rely	VBP
cord-001835-0s7ok4uw	5024	15	on	on	IN
cord-001835-0s7ok4uw	5024	16	stable	stable	JJ
cord-001835-0s7ok4uw	5024	17	scaffolds	scaffold	NNS
cord-001835-0s7ok4uw	5024	18	.	.	.
cord-001835-0s7ok4uw	5025	1	Symmetry	Symmetry	NNP
cord-001835-0s7ok4uw	5025	2	is	be	VBZ
cord-001835-0s7ok4uw	5025	3	a	a	DT
cord-001835-0s7ok4uw	5025	4	great	great	JJ
cord-001835-0s7ok4uw	5025	5	tool	tool	NN
cord-001835-0s7ok4uw	5025	6	for	for	IN
cord-001835-0s7ok4uw	5025	7	protein	protein	NN
cord-001835-0s7ok4uw	5025	8	stability	stability	NN
cord-001835-0s7ok4uw	5025	9	both	both	CC
cord-001835-0s7ok4uw	5025	10	in	in	IN
cord-001835-0s7ok4uw	5025	11	protein	protein	NN
cord-001835-0s7ok4uw	5025	12	engineering	engineering	NN
cord-001835-0s7ok4uw	5025	13	and	and	CC
cord-001835-0s7ok4uw	5025	14	nature	nature	NN
cord-001835-0s7ok4uw	5025	15	.	.	.
cord-001835-0s7ok4uw	5026	1	Several	several	JJ
cord-001835-0s7ok4uw	5026	2	membrane	membrane	NN
cord-001835-0s7ok4uw	5026	3	protein	protein	NN
cord-001835-0s7ok4uw	5026	4	structures	structure	NNS
cord-001835-0s7ok4uw	5026	5	exhibit	exhibit	VBP
cord-001835-0s7ok4uw	5026	6	pseudo	pseudo	JJ
cord-001835-0s7ok4uw	5026	7	-	-	NN
cord-001835-0s7ok4uw	5026	8	symmetry	symmetry	NN
cord-001835-0s7ok4uw	5026	9	and	and	CC
cord-001835-0s7ok4uw	5026	10	are	be	VBP
cord-001835-0s7ok4uw	5026	11	proposed	propose	VBN
cord-001835-0s7ok4uw	5026	12	to	to	TO
cord-001835-0s7ok4uw	5026	13	be	be	VB
cord-001835-0s7ok4uw	5026	14	the	the	DT
cord-001835-0s7ok4uw	5026	15	result	result	NN
cord-001835-0s7ok4uw	5026	16	of	of	IN
cord-001835-0s7ok4uw	5026	17	gene	gene	NN
cord-001835-0s7ok4uw	5026	18	duplication	duplication	NN
cord-001835-0s7ok4uw	5026	19	,	,	,
cord-001835-0s7ok4uw	5026	20	fusion	fusion	NN
cord-001835-0s7ok4uw	5026	21	and	and	CC
cord-001835-0s7ok4uw	5026	22	diversification	diversification	NN
cord-001835-0s7ok4uw	5026	23	events	event	NNS
cord-001835-0s7ok4uw	5026	24	originating	originate	VBG
cord-001835-0s7ok4uw	5026	25	from	from	IN
cord-001835-0s7ok4uw	5026	26	a	a	DT
cord-001835-0s7ok4uw	5026	27	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	5026	28	gene	gene	NN
cord-001835-0s7ok4uw	5026	29	.	.	.
cord-001835-0s7ok4uw	5027	1	Aquaporins	Aquaporins	NNP
cord-001835-0s7ok4uw	5027	2	(	(	-LRB-
cord-001835-0s7ok4uw	5027	3	AQP	AQP	NNP
cord-001835-0s7ok4uw	5027	4	)	)	-RRB-
cord-001835-0s7ok4uw	5027	5	are	be	VBP
cord-001835-0s7ok4uw	5027	6	a	a	DT
cord-001835-0s7ok4uw	5027	7	class	class	NN
cord-001835-0s7ok4uw	5027	8	of	of	IN
cord-001835-0s7ok4uw	5027	9	membrane	membrane	NN
cord-001835-0s7ok4uw	5027	10	proteins	protein	NNS
cord-001835-0s7ok4uw	5027	11	that	that	WDT
cord-001835-0s7ok4uw	5027	12	exhibits	exhibit	VBZ
cord-001835-0s7ok4uw	5027	13	a	a	DT
cord-001835-0s7ok4uw	5027	14	two	two	CD
cord-001835-0s7ok4uw	5027	15	-	-	HYPH
cord-001835-0s7ok4uw	5027	16	fold	fold	JJ
cord-001835-0s7ok4uw	5027	17	inverted	inverted	JJ
cord-001835-0s7ok4uw	5027	18	pseudo	pseudo	JJ
cord-001835-0s7ok4uw	5027	19	-	-	NN
cord-001835-0s7ok4uw	5027	20	symmetry	symmetry	NN
cord-001835-0s7ok4uw	5027	21	.	.	.
cord-001835-0s7ok4uw	5028	1	The	the	DT
cord-001835-0s7ok4uw	5028	2	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	5028	3	coli	coli	NNS
cord-001835-0s7ok4uw	5028	4	AQP	AQP	NNP
cord-001835-0s7ok4uw	5028	5	Glycerol	glycerol	NN
cord-001835-0s7ok4uw	5028	6	facilitator	facilitator	NN
cord-001835-0s7ok4uw	5028	7	protein	protein	NN
cord-001835-0s7ok4uw	5028	8	(	(	-LRB-
cord-001835-0s7ok4uw	5028	9	GlpF	GlpF	NNP
cord-001835-0s7ok4uw	5028	10	)	)	-RRB-
cord-001835-0s7ok4uw	5028	11	was	be	VBD
cord-001835-0s7ok4uw	5028	12	originally	originally	RB
cord-001835-0s7ok4uw	5028	13	computationally	computationally	RB
cord-001835-0s7ok4uw	5028	14	engineered	engineer	VBN
cord-001835-0s7ok4uw	5028	15	to	to	TO
cord-001835-0s7ok4uw	5028	16	be	be	VB
cord-001835-0s7ok4uw	5028	17	perfectly	perfectly	RB
cord-001835-0s7ok4uw	5028	18	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	5028	19	in	in	IN
cord-001835-0s7ok4uw	5028	20	sequence	sequence	NN
cord-001835-0s7ok4uw	5028	21	and	and	CC
cord-001835-0s7ok4uw	5028	22	presumably	presumably	RB
cord-001835-0s7ok4uw	5028	23	in	in	IN
cord-001835-0s7ok4uw	5028	24	structure	structure	NN
cord-001835-0s7ok4uw	5028	25	.	.	.
cord-001835-0s7ok4uw	5029	1	The	the	DT
cord-001835-0s7ok4uw	5029	2	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	5029	3	gene	gene	NN
cord-001835-0s7ok4uw	5029	4	was	be	VBD
cord-001835-0s7ok4uw	5029	5	assembled	assemble	VBN
cord-001835-0s7ok4uw	5029	6	,	,	,
cord-001835-0s7ok4uw	5029	7	cloned	clone	VBN
cord-001835-0s7ok4uw	5029	8	,	,	,
cord-001835-0s7ok4uw	5029	9	and	and	CC
cord-001835-0s7ok4uw	5029	10	expressed	express	VBD
cord-001835-0s7ok4uw	5029	11	.	.	.
cord-001835-0s7ok4uw	5030	1	However	however	RB
cord-001835-0s7ok4uw	5030	2	,	,	,
cord-001835-0s7ok4uw	5030	3	after	after	IN
cord-001835-0s7ok4uw	5030	4	facing	face	VBG
cord-001835-0s7ok4uw	5030	5	many	many	JJ
cord-001835-0s7ok4uw	5030	6	challenges	challenge	NNS
cord-001835-0s7ok4uw	5030	7	experimentally	experimentally	RB
cord-001835-0s7ok4uw	5030	8	,	,	,
cord-001835-0s7ok4uw	5030	9	the	the	DT
cord-001835-0s7ok4uw	5030	10	computational	computational	JJ
cord-001835-0s7ok4uw	5030	11	study	study	NN
cord-001835-0s7ok4uw	5030	12	has	have	VBZ
cord-001835-0s7ok4uw	5030	13	been	be	VBN
cord-001835-0s7ok4uw	5030	14	expanded	expand	VBN
cord-001835-0s7ok4uw	5030	15	to	to	IN
cord-001835-0s7ok4uw	5030	16	13	13	CD
cord-001835-0s7ok4uw	5030	17	AQPs	aqp	NNS
cord-001835-0s7ok4uw	5030	18	of	of	IN
cord-001835-0s7ok4uw	5030	19	known	know	VBN
cord-001835-0s7ok4uw	5030	20	structure	structure	NN
cord-001835-0s7ok4uw	5030	21	for	for	IN
cord-001835-0s7ok4uw	5030	22	a	a	DT
cord-001835-0s7ok4uw	5030	23	more	more	RBR
cord-001835-0s7ok4uw	5030	24	extensive	extensive	JJ
cord-001835-0s7ok4uw	5030	25	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	5030	26	backbone	backbone	NN
cord-001835-0s7ok4uw	5030	27	search	search	NN
cord-001835-0s7ok4uw	5030	28	.	.	.
cord-001835-0s7ok4uw	5031	1	MAMMOTH	mammoth	JJ
cord-001835-0s7ok4uw	5031	2	structural	structural	JJ
cord-001835-0s7ok4uw	5031	3	alignment	alignment	NN
cord-001835-0s7ok4uw	5031	4	was	be	VBD
cord-001835-0s7ok4uw	5031	5	used	use	VBN
cord-001835-0s7ok4uw	5031	6	to	to	TO
cord-001835-0s7ok4uw	5031	7	align	align	VB
cord-001835-0s7ok4uw	5031	8	the	the	DT
cord-001835-0s7ok4uw	5031	9	structures	structure	NNS
cord-001835-0s7ok4uw	5031	10	to	to	IN
cord-001835-0s7ok4uw	5031	11	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5031	12	inverted	inverted	JJ
cord-001835-0s7ok4uw	5031	13	counterparts	counterpart	NNS
cord-001835-0s7ok4uw	5031	14	.	.	.
cord-001835-0s7ok4uw	5032	1	Cutpoints	cutpoint	NNS
cord-001835-0s7ok4uw	5032	2	were	be	VBD
cord-001835-0s7ok4uw	5032	3	calculated	calculate	VBN
cord-001835-0s7ok4uw	5032	4	based	base	VBN
cord-001835-0s7ok4uw	5032	5	on	on	IN
cord-001835-0s7ok4uw	5032	6	a	a	DT
cord-001835-0s7ok4uw	5032	7	-	-	HYPH
cord-001835-0s7ok4uw	5032	8	Carbon	carbon	NN
cord-001835-0s7ok4uw	5032	9	distance	distance	NN
cord-001835-0s7ok4uw	5032	10	.	.	.
cord-001835-0s7ok4uw	5033	1	Finally	finally	RB
cord-001835-0s7ok4uw	5033	2	,	,	,
cord-001835-0s7ok4uw	5033	3	the	the	DT
cord-001835-0s7ok4uw	5033	4	Rosetta	Rosetta	NNP
cord-001835-0s7ok4uw	5033	5	Protein	Protein	NNP
cord-001835-0s7ok4uw	5033	6	Modeling	Modeling	NNP
cord-001835-0s7ok4uw	5033	7	Software	Software	NNP
cord-001835-0s7ok4uw	5033	8	Suite	Suite	NNP
cord-001835-0s7ok4uw	5033	9	was	be	VBD
cord-001835-0s7ok4uw	5033	10	used	use	VBN
cord-001835-0s7ok4uw	5033	11	to	to	TO
cord-001835-0s7ok4uw	5033	12	refine	refine	VB
cord-001835-0s7ok4uw	5033	13	and	and	CC
cord-001835-0s7ok4uw	5033	14	energetically	energetically	RB
cord-001835-0s7ok4uw	5033	15	minimize	minimize	VB
cord-001835-0s7ok4uw	5033	16	the	the	DT
cord-001835-0s7ok4uw	5033	17	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	5033	18	backbones	backbone	NNS
cord-001835-0s7ok4uw	5033	19	.	.	.
cord-001835-0s7ok4uw	5034	1	From	from	IN
cord-001835-0s7ok4uw	5034	2	over	over	IN
cord-001835-0s7ok4uw	5034	3	1500	1500	CD
cord-001835-0s7ok4uw	5034	4	generated	generate	VBN
cord-001835-0s7ok4uw	5034	5	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	5034	6	backbones	backbone	NNS
cord-001835-0s7ok4uw	5034	7	,	,	,
cord-001835-0s7ok4uw	5034	8	20	20	CD
cord-001835-0s7ok4uw	5034	9	candidates	candidate	NNS
cord-001835-0s7ok4uw	5034	10	were	be	VBD
cord-001835-0s7ok4uw	5034	11	chosen	choose	VBN
cord-001835-0s7ok4uw	5034	12	for	for	IN
cord-001835-0s7ok4uw	5034	13	experimental	experimental	JJ
cord-001835-0s7ok4uw	5034	14	verification	verification	NN
cord-001835-0s7ok4uw	5034	15	.	.	.
cord-001835-0s7ok4uw	5035	1	These	these	DT
cord-001835-0s7ok4uw	5035	2	studies	study	NNS
cord-001835-0s7ok4uw	5035	3	are	be	VBP
cord-001835-0s7ok4uw	5035	4	ongoing	ongoing	JJ
cord-001835-0s7ok4uw	5035	5	.	.	.
cord-001835-0s7ok4uw	5036	1	Currently	currently	RB
cord-001835-0s7ok4uw	5036	2	,	,	,
cord-001835-0s7ok4uw	5036	3	the	the	DT
cord-001835-0s7ok4uw	5036	4	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	5036	5	backbone	backbone	NN
cord-001835-0s7ok4uw	5036	6	models	model	NNS
cord-001835-0s7ok4uw	5036	7	have	have	VBP
cord-001835-0s7ok4uw	5036	8	scored	score	VBN
cord-001835-0s7ok4uw	5036	9	to	to	TO
cord-001835-0s7ok4uw	5036	10	be	be	VB
cord-001835-0s7ok4uw	5036	11	more	more	RBR
cord-001835-0s7ok4uw	5036	12	stable	stable	JJ
cord-001835-0s7ok4uw	5036	13	than	than	IN
cord-001835-0s7ok4uw	5036	14	the	the	DT
cord-001835-0s7ok4uw	5036	15	wild	wild	JJ
cord-001835-0s7ok4uw	5036	16	-	-	HYPH
cord-001835-0s7ok4uw	5036	17	type	type	NN
cord-001835-0s7ok4uw	5036	18	proteins	protein	NNS
cord-001835-0s7ok4uw	5036	19	.	.	.
cord-001835-0s7ok4uw	5037	1	Experimental	experimental	JJ
cord-001835-0s7ok4uw	5037	2	verification	verification	NN
cord-001835-0s7ok4uw	5037	3	of	of	IN
cord-001835-0s7ok4uw	5037	4	these	these	DT
cord-001835-0s7ok4uw	5037	5	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	5037	6	backbones	backbone	NNS
cord-001835-0s7ok4uw	5037	7	will	will	MD
cord-001835-0s7ok4uw	5037	8	provide	provide	VB
cord-001835-0s7ok4uw	5037	9	valuable	valuable	JJ
cord-001835-0s7ok4uw	5037	10	information	information	NN
cord-001835-0s7ok4uw	5037	11	for	for	IN
cord-001835-0s7ok4uw	5037	12	the	the	DT
cord-001835-0s7ok4uw	5037	13	current	current	JJ
cord-001835-0s7ok4uw	5037	14	state	state	NN
cord-001835-0s7ok4uw	5037	15	of	of	IN
cord-001835-0s7ok4uw	5037	16	membrane	membrane	NN
cord-001835-0s7ok4uw	5037	17	protein	protein	NN
cord-001835-0s7ok4uw	5037	18	modeling	modeling	NN
cord-001835-0s7ok4uw	5037	19	and	and	CC
cord-001835-0s7ok4uw	5037	20	design	design	NN
cord-001835-0s7ok4uw	5037	21	using	use	VBG
cord-001835-0s7ok4uw	5037	22	computational	computational	JJ
cord-001835-0s7ok4uw	5037	23	methods	method	NNS
cord-001835-0s7ok4uw	5037	24	.	.	.
cord-001835-0s7ok4uw	5038	1	Intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	5038	2	disordered	disordered	JJ
cord-001835-0s7ok4uw	5038	3	proteins	protein	NNS
cord-001835-0s7ok4uw	5038	4	drive	drive	VBP
cord-001835-0s7ok4uw	5038	5	heritable	heritable	JJ
cord-001835-0s7ok4uw	5038	6	transformations	transformation	NNS
cord-001835-0s7ok4uw	5038	7	of	of	IN
cord-001835-0s7ok4uw	5038	8	biological	biological	JJ
cord-001835-0s7ok4uw	5038	9	traits	trait	NNS
cord-001835-0s7ok4uw	5038	10	Daniel	Daniel	NNP
cord-001835-0s7ok4uw	5038	11	Jarosz	Jarosz	NNP
cord-001835-0s7ok4uw	5038	12	1	1	CD
cord-001835-0s7ok4uw	5038	13	,	,	,
cord-001835-0s7ok4uw	5038	14	James	James	NNP
cord-001835-0s7ok4uw	5038	15	Byers	Byers	NNP
cord-001835-0s7ok4uw	5038	16	1	1	CD
cord-001835-0s7ok4uw	5038	17	,	,	,
cord-001835-0s7ok4uw	5038	18	Sohini	Sohini	NNP
cord-001835-0s7ok4uw	5038	19	Chakrabortee	Chakrabortee	NNP
cord-001835-0s7ok4uw	5038	20	2	2	CD
cord-001835-0s7ok4uw	5038	21	,	,	,
cord-001835-0s7ok4uw	5038	22	Sandra	Sandra	NNP
cord-001835-0s7ok4uw	5038	23	Jones	Jones	NNP
cord-001835-0s7ok4uw	5038	24	3	3	CD
cord-001835-0s7ok4uw	5038	25	,	,	,
cord-001835-0s7ok4uw	5038	26	Amelia	Amelia	NNP
cord-001835-0s7ok4uw	5038	27	Chang	Chang	NNP
cord-001835-0s7ok4uw	5038	28	2	2	CD
cord-001835-0s7ok4uw	5038	29	,	,	,
cord-001835-0s7ok4uw	5038	30	David	David	NNP
cord-001835-0s7ok4uw	5038	31	Garcia	Garcia	NNP
cord-001835-0s7ok4uw	5038	32	1	1	CD
cord-001835-0s7ok4uw	5038	33	1	1	CD
cord-001835-0s7ok4uw	5038	34	Stanford	Stanford	NNP
cord-001835-0s7ok4uw	5038	35	University	University	NNP
cord-001835-0s7ok4uw	5038	36	,	,	,
cord-001835-0s7ok4uw	5038	37	2	2	CD
cord-001835-0s7ok4uw	5038	38	Whitehead	Whitehead	NNP
cord-001835-0s7ok4uw	5038	39	Institute	Institute	NNP
cord-001835-0s7ok4uw	5038	40	for	for	IN
cord-001835-0s7ok4uw	5038	41	Biomedical	Biomedical	NNP
cord-001835-0s7ok4uw	5038	42	Research	Research	NNP
cord-001835-0s7ok4uw	5038	43	,	,	,
cord-001835-0s7ok4uw	5038	44	3	3	CD
cord-001835-0s7ok4uw	5038	45	Rockefeller	Rockefeller	NNP
cord-001835-0s7ok4uw	5038	46	University	University	NNP
cord-001835-0s7ok4uw	5039	1	The	the	DT
cord-001835-0s7ok4uw	5039	2	transmission	transmission	NN
cord-001835-0s7ok4uw	5039	3	of	of	IN
cord-001835-0s7ok4uw	5039	4	information	information	NN
cord-001835-0s7ok4uw	5039	5	from	from	IN
cord-001835-0s7ok4uw	5039	6	one	one	CD
cord-001835-0s7ok4uw	5039	7	generation	generation	NN
cord-001835-0s7ok4uw	5039	8	to	to	IN
cord-001835-0s7ok4uw	5039	9	the	the	DT
cord-001835-0s7ok4uw	5039	10	next	next	JJ
cord-001835-0s7ok4uw	5039	11	generally	generally	RB
cord-001835-0s7ok4uw	5039	12	occurs	occur	VBZ
cord-001835-0s7ok4uw	5039	13	via	via	IN
cord-001835-0s7ok4uw	5039	14	nucleic	nucleic	JJ
cord-001835-0s7ok4uw	5039	15	acids	acid	NNS
cord-001835-0s7ok4uw	5039	16	.	.	.
cord-001835-0s7ok4uw	5040	1	The	the	DT
cord-001835-0s7ok4uw	5040	2	only	only	RB
cord-001835-0s7ok4uw	5040	3	known	know	VBN
cord-001835-0s7ok4uw	5040	4	protein	protein	NN
cord-001835-0s7ok4uw	5040	5	-	-	HYPH
cord-001835-0s7ok4uw	5040	6	based	base	VBN
cord-001835-0s7ok4uw	5040	7	molecular	molecular	JJ
cord-001835-0s7ok4uw	5040	8	memories	memory	NNS
cord-001835-0s7ok4uw	5040	9	are	be	VBP
cord-001835-0s7ok4uw	5040	10	prions	prion	NNS
cord-001835-0s7ok4uw	5040	11	,	,	,
cord-001835-0s7ok4uw	5040	12	which	which	WDT
cord-001835-0s7ok4uw	5040	13	drive	drive	VBP
cord-001835-0s7ok4uw	5040	14	heritable	heritable	JJ
cord-001835-0s7ok4uw	5040	15	biological	biological	JJ
cord-001835-0s7ok4uw	5040	16	traits	trait	NNS
cord-001835-0s7ok4uw	5040	17	based	base	VBN
cord-001835-0s7ok4uw	5040	18	upon	upon	IN
cord-001835-0s7ok4uw	5040	19	self	self	NN
cord-001835-0s7ok4uw	5040	20	-	-	HYPH
cord-001835-0s7ok4uw	5040	21	templating	templating	NN
cord-001835-0s7ok4uw	5040	22	changes	change	NNS
cord-001835-0s7ok4uw	5040	23	in	in	IN
cord-001835-0s7ok4uw	5040	24	protein	protein	NN
cord-001835-0s7ok4uw	5040	25	conformation	conformation	NN
cord-001835-0s7ok4uw	5040	26	.	.	.
cord-001835-0s7ok4uw	5041	1	These	these	DT
cord-001835-0s7ok4uw	5041	2	protein	protein	NN
cord-001835-0s7ok4uw	5041	3	-	-	HYPH
cord-001835-0s7ok4uw	5041	4	based	base	VBN
cord-001835-0s7ok4uw	5041	5	genetic	genetic	JJ
cord-001835-0s7ok4uw	5041	6	elements	element	NNS
cord-001835-0s7ok4uw	5041	7	have	have	VBP
cord-001835-0s7ok4uw	5041	8	previously	previously	RB
cord-001835-0s7ok4uw	5041	9	been	be	VBN
cord-001835-0s7ok4uw	5041	10	identified	identify	VBN
cord-001835-0s7ok4uw	5041	11	systematically	systematically	RB
cord-001835-0s7ok4uw	5041	12	,	,	,
cord-001835-0s7ok4uw	5041	13	but	but	CC
cord-001835-0s7ok4uw	5041	14	at	at	RB
cord-001835-0s7ok4uw	5041	15	least	least	RBS
cord-001835-0s7ok4uw	5041	16	three	three	CD
cord-001835-0s7ok4uw	5041	17	do	do	VBP
cord-001835-0s7ok4uw	5041	18	not	not	RB
cord-001835-0s7ok4uw	5041	19	share	share	VB
cord-001835-0s7ok4uw	5041	20	the	the	DT
cord-001835-0s7ok4uw	5041	21	sequence	sequence	NN
cord-001835-0s7ok4uw	5041	22	biases	bias	NNS
cord-001835-0s7ok4uw	5041	23	or	or	CC
cord-001835-0s7ok4uw	5041	24	structural	structural	JJ
cord-001835-0s7ok4uw	5041	25	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	5041	26	that	that	WDT
cord-001835-0s7ok4uw	5041	27	have	have	VBP
cord-001835-0s7ok4uw	5041	28	informed	inform	VBN
cord-001835-0s7ok4uw	5041	29	such	such	JJ
cord-001835-0s7ok4uw	5041	30	studies	study	NNS
cord-001835-0s7ok4uw	5041	31	.	.	.
cord-001835-0s7ok4uw	5042	1	Here	here	RB
cord-001835-0s7ok4uw	5042	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	5042	3	employed	employ	VBD
cord-001835-0s7ok4uw	5042	4	a	a	DT
cord-001835-0s7ok4uw	5042	5	comprehensive	comprehensive	JJ
cord-001835-0s7ok4uw	5042	6	library	library	NN
cord-001835-0s7ok4uw	5042	7	of	of	IN
cord-001835-0s7ok4uw	5042	8	yeast	yeast	NN
cord-001835-0s7ok4uw	5042	9	proteins	protein	NNS
cord-001835-0s7ok4uw	5042	10	to	to	TO
cord-001835-0s7ok4uw	5042	11	examine	examine	VB
cord-001835-0s7ok4uw	5042	12	the	the	DT
cord-001835-0s7ok4uw	5042	13	breadth	breadth	NN
cord-001835-0s7ok4uw	5042	14	of	of	IN
cord-001835-0s7ok4uw	5042	15	protein	protein	NN
cord-001835-0s7ok4uw	5042	16	-	-	HYPH
cord-001835-0s7ok4uw	5042	17	based	base	VBN
cord-001835-0s7ok4uw	5042	18	inheritance	inheritance	NN
cord-001835-0s7ok4uw	5042	19	.	.	.
cord-001835-0s7ok4uw	5043	1	Transient	transient	JJ
cord-001835-0s7ok4uw	5043	2	overexpression	overexpression	NN
cord-001835-0s7ok4uw	5043	3	of	of	IN
cord-001835-0s7ok4uw	5043	4	more	more	JJR
cord-001835-0s7ok4uw	5043	5	than	than	IN
cord-001835-0s7ok4uw	5043	6	forty	forty	CD
cord-001835-0s7ok4uw	5043	7	proteins	protein	NNS
cord-001835-0s7ok4uw	5043	8	created	create	VBD
cord-001835-0s7ok4uw	5043	9	new	new	JJ
cord-001835-0s7ok4uw	5043	10	traits	trait	NNS
cord-001835-0s7ok4uw	5043	11	that	that	WDT
cord-001835-0s7ok4uw	5043	12	were	be	VBD
cord-001835-0s7ok4uw	5043	13	heritable	heritable	JJ
cord-001835-0s7ok4uw	5043	14	and	and	CC
cord-001835-0s7ok4uw	5043	15	beneficial	beneficial	JJ
cord-001835-0s7ok4uw	5043	16	.	.	.
cord-001835-0s7ok4uw	5044	1	Some	some	DT
cord-001835-0s7ok4uw	5044	2	shared	share	VBN
cord-001835-0s7ok4uw	5044	3	properties	property	NNS
cord-001835-0s7ok4uw	5044	4	of	of	IN
cord-001835-0s7ok4uw	5044	5	known	know	VBN
cord-001835-0s7ok4uw	5044	6	prions	prion	NNS
cord-001835-0s7ok4uw	5044	7	,	,	,
cord-001835-0s7ok4uw	5044	8	but	but	CC
cord-001835-0s7ok4uw	5044	9	most	most	JJS
cord-001835-0s7ok4uw	5044	10	employed	employ	VBN
cord-001835-0s7ok4uw	5044	11	distinct	distinct	JJ
cord-001835-0s7ok4uw	5044	12	genetic	genetic	JJ
cord-001835-0s7ok4uw	5044	13	and	and	CC
cord-001835-0s7ok4uw	5044	14	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5044	15	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	5044	16	to	to	TO
cord-001835-0s7ok4uw	5044	17	act	act	VB
cord-001835-0s7ok4uw	5044	18	as	as	IN
cord-001835-0s7ok4uw	5044	19	elements	element	NNS
cord-001835-0s7ok4uw	5044	20	of	of	IN
cord-001835-0s7ok4uw	5044	21	inheritance	inheritance	NN
cord-001835-0s7ok4uw	5044	22	.	.	.
cord-001835-0s7ok4uw	5045	1	Traits	trait	NNS
cord-001835-0s7ok4uw	5045	2	with	with	IN
cord-001835-0s7ok4uw	5045	3	these	these	DT
cord-001835-0s7ok4uw	5045	4	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	5045	5	were	be	VBD
cord-001835-0s7ok4uw	5045	6	common	common	JJ
cord-001835-0s7ok4uw	5045	7	in	in	IN
cord-001835-0s7ok4uw	5045	8	wild	wild	JJ
cord-001835-0s7ok4uw	5045	9	yeast	yeast	NN
cord-001835-0s7ok4uw	5045	10	strains	strain	NNS
cord-001835-0s7ok4uw	5045	11	and	and	CC
cord-001835-0s7ok4uw	5045	12	could	could	MD
cord-001835-0s7ok4uw	5045	13	also	also	RB
cord-001835-0s7ok4uw	5045	14	be	be	VB
cord-001835-0s7ok4uw	5045	15	elicited	elicit	VBN
cord-001835-0s7ok4uw	5045	16	using	use	VBG
cord-001835-0s7ok4uw	5045	17	orthologous	orthologous	JJ
cord-001835-0s7ok4uw	5045	18	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	5045	19	proteins	protein	NNS
cord-001835-0s7ok4uw	5045	20	.	.	.
cord-001835-0s7ok4uw	5046	1	The	the	DT
cord-001835-0s7ok4uw	5046	2	inducing	induce	VBG
cord-001835-0s7ok4uw	5046	3	proteins	protein	NNS
cord-001835-0s7ok4uw	5046	4	were	be	VBD
cord-001835-0s7ok4uw	5046	5	strikingly	strikingly	RB
cord-001835-0s7ok4uw	5046	6	enriched	enrich	VBN
cord-001835-0s7ok4uw	5046	7	in	in	IN
cord-001835-0s7ok4uw	5046	8	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	5046	9	disordered	disordered	JJ
cord-001835-0s7ok4uw	5046	10	sequences	sequence	NNS
cord-001835-0s7ok4uw	5046	11	that	that	WDT
cord-001835-0s7ok4uw	5046	12	have	have	VBP
cord-001835-0s7ok4uw	5046	13	been	be	VBN
cord-001835-0s7ok4uw	5046	14	widely	widely	RB
cord-001835-0s7ok4uw	5046	15	conserved	conserve	VBN
cord-001835-0s7ok4uw	5046	16	across	across	IN
cord-001835-0s7ok4uw	5046	17	evolution	evolution	NN
cord-001835-0s7ok4uw	5046	18	.	.	.
cord-001835-0s7ok4uw	5047	1	Intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	5047	2	disordered	disordered	JJ
cord-001835-0s7ok4uw	5047	3	proteins	protein	NNS
cord-001835-0s7ok4uw	5047	4	are	be	VBP
cord-001835-0s7ok4uw	5047	5	associated	associate	VBN
cord-001835-0s7ok4uw	5047	6	with	with	IN
cord-001835-0s7ok4uw	5047	7	human	human	JJ
cord-001835-0s7ok4uw	5047	8	disease	disease	NN
cord-001835-0s7ok4uw	5047	9	and	and	CC
cord-001835-0s7ok4uw	5047	10	with	with	IN
cord-001835-0s7ok4uw	5047	11	dosage	dosage	NN
cord-001835-0s7ok4uw	5047	12	sensitivity	sensitivity	NN
cord-001835-0s7ok4uw	5047	13	in	in	IN
cord-001835-0s7ok4uw	5047	14	yeast	yeast	NN
cord-001835-0s7ok4uw	5047	15	,	,	,
cord-001835-0s7ok4uw	5047	16	flies	fly	NNS
cord-001835-0s7ok4uw	5047	17	and	and	CC
cord-001835-0s7ok4uw	5047	18	worms	worm	NNS
cord-001835-0s7ok4uw	5047	19	.	.	.
cord-001835-0s7ok4uw	5048	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	5048	2	results	result	NNS
cord-001835-0s7ok4uw	5048	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	5048	4	another	another	DT
cord-001835-0s7ok4uw	5048	5	widespread	widespread	JJ
cord-001835-0s7ok4uw	5048	6	role	role	NN
cord-001835-0s7ok4uw	5048	7	for	for	IN
cord-001835-0s7ok4uw	5048	8	such	such	JJ
cord-001835-0s7ok4uw	5048	9	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	5048	10	disordered	disordered	JJ
cord-001835-0s7ok4uw	5048	11	sequences	sequence	NNS
cord-001835-0s7ok4uw	5048	12	:	:	:
cord-001835-0s7ok4uw	5048	13	induction	induction	NN
cord-001835-0s7ok4uw	5048	14	of	of	IN
cord-001835-0s7ok4uw	5048	15	heritable	heritable	JJ
cord-001835-0s7ok4uw	5048	16	epigenetic	epigenetic	JJ
cord-001835-0s7ok4uw	5048	17	switches	switch	NNS
cord-001835-0s7ok4uw	5048	18	that	that	WDT
cord-001835-0s7ok4uw	5048	19	transform	transform	VBP
cord-001835-0s7ok4uw	5048	20	phenotypic	phenotypic	JJ
cord-001835-0s7ok4uw	5048	21	landscapes	landscape	NNS
cord-001835-0s7ok4uw	5048	22	and	and	CC
cord-001835-0s7ok4uw	5048	23	drive	drive	VB
cord-001835-0s7ok4uw	5048	24	adaptation	adaptation	NN
cord-001835-0s7ok4uw	5048	25	to	to	IN
cord-001835-0s7ok4uw	5048	26	stressful	stressful	JJ
cord-001835-0s7ok4uw	5048	27	environments	environment	NNS
cord-001835-0s7ok4uw	5048	28	.	.	.
cord-001835-0s7ok4uw	5049	1	Prediction	prediction	NN
cord-001835-0s7ok4uw	5049	2	of	of	IN
cord-001835-0s7ok4uw	5049	3	binding	bind	VBG
cord-001835-0s7ok4uw	5049	4	affinity	affinity	NN
cord-001835-0s7ok4uw	5049	5	in	in	IN
cord-001835-0s7ok4uw	5049	6	protein	protein	NN
cord-001835-0s7ok4uw	5049	7	complexes	complex	NNS
cord-001835-0s7ok4uw	5049	8	:	:	:
cord-001835-0s7ok4uw	5049	9	contacts	contact	NNS
cord-001835-0s7ok4uw	5049	10	do	do	VBP
cord-001835-0s7ok4uw	5049	11	matters	matter	NNS
cord-001835-0s7ok4uw	5049	12	Almost	almost	RB
cord-001835-0s7ok4uw	5049	13	all	all	DT
cord-001835-0s7ok4uw	5049	14	critical	critical	JJ
cord-001835-0s7ok4uw	5049	15	functions	function	NNS
cord-001835-0s7ok4uw	5049	16	in	in	IN
cord-001835-0s7ok4uw	5049	17	cells	cell	NNS
cord-001835-0s7ok4uw	5049	18	rely	rely	VBP
cord-001835-0s7ok4uw	5049	19	on	on	IN
cord-001835-0s7ok4uw	5049	20	specific	specific	JJ
cord-001835-0s7ok4uw	5049	21	protein	protein	NN
cord-001835-0s7ok4uw	5049	22	-	-	HYPH
cord-001835-0s7ok4uw	5049	23	protein	protein	NN
cord-001835-0s7ok4uw	5049	24	interactions	interaction	NNS
cord-001835-0s7ok4uw	5049	25	.	.	.
cord-001835-0s7ok4uw	5050	1	Understanding	understand	VBG
cord-001835-0s7ok4uw	5050	2	these	these	DT
cord-001835-0s7ok4uw	5050	3	is	be	VBZ
cord-001835-0s7ok4uw	5050	4	therefore	therefore	RB
cord-001835-0s7ok4uw	5050	5	crucial	crucial	JJ
cord-001835-0s7ok4uw	5050	6	in	in	IN
cord-001835-0s7ok4uw	5050	7	the	the	DT
cord-001835-0s7ok4uw	5050	8	investigation	investigation	NN
cord-001835-0s7ok4uw	5050	9	of	of	IN
cord-001835-0s7ok4uw	5050	10	biological	biological	JJ
cord-001835-0s7ok4uw	5050	11	systems	system	NNS
cord-001835-0s7ok4uw	5050	12	.	.	.
cord-001835-0s7ok4uw	5051	1	Despite	despite	IN
cord-001835-0s7ok4uw	5051	2	all	all	DT
cord-001835-0s7ok4uw	5051	3	past	past	JJ
cord-001835-0s7ok4uw	5051	4	efforts	effort	NNS
cord-001835-0s7ok4uw	5051	5	,	,	,
cord-001835-0s7ok4uw	5051	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	5051	7	still	still	RB
cord-001835-0s7ok4uw	5051	8	lack	lack	VBP
cord-001835-0s7ok4uw	5051	9	a	a	DT
cord-001835-0s7ok4uw	5051	10	thorough	thorough	JJ
cord-001835-0s7ok4uw	5051	11	understanding	understanding	NN
cord-001835-0s7ok4uw	5051	12	of	of	IN
cord-001835-0s7ok4uw	5051	13	the	the	DT
cord-001835-0s7ok4uw	5051	14	energetics	energetic	NNS
cord-001835-0s7ok4uw	5051	15	of	of	IN
cord-001835-0s7ok4uw	5051	16	association	association	NNP
cord-001835-0s7ok4uw	5051	17	of	of	IN
cord-001835-0s7ok4uw	5051	18	proteins	protein	NNS
cord-001835-0s7ok4uw	5051	19	.	.	.
cord-001835-0s7ok4uw	5052	1	Here	here	RB
cord-001835-0s7ok4uw	5052	2	,	,	,
cord-001835-0s7ok4uw	5052	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	5052	4	introduce	introduce	VBP
cord-001835-0s7ok4uw	5052	5	a	a	DT
cord-001835-0s7ok4uw	5052	6	new	new	JJ
cord-001835-0s7ok4uw	5052	7	and	and	CC
cord-001835-0s7ok4uw	5052	8	simple	simple	JJ
cord-001835-0s7ok4uw	5052	9	approach	approach	NN
cord-001835-0s7ok4uw	5052	10	to	to	TO
cord-001835-0s7ok4uw	5052	11	predict	predict	VB
cord-001835-0s7ok4uw	5052	12	binding	bind	VBG
cord-001835-0s7ok4uw	5052	13	affinity	affinity	NN
cord-001835-0s7ok4uw	5052	14	based	base	VBN
cord-001835-0s7ok4uw	5052	15	on	on	IN
cord-001835-0s7ok4uw	5052	16	functional	functional	JJ
cord-001835-0s7ok4uw	5052	17	and	and	CC
cord-001835-0s7ok4uw	5052	18	structural	structural	JJ
cord-001835-0s7ok4uw	5052	19	features	feature	NNS
cord-001835-0s7ok4uw	5052	20	of	of	IN
cord-001835-0s7ok4uw	5052	21	the	the	DT
cord-001835-0s7ok4uw	5052	22	biological	biological	JJ
cord-001835-0s7ok4uw	5052	23	system	system	NN
cord-001835-0s7ok4uw	5052	24	,	,	,
cord-001835-0s7ok4uw	5052	25	namely	namely	RB
cord-001835-0s7ok4uw	5052	26	the	the	DT
cord-001835-0s7ok4uw	5052	27	network	network	NN
cord-001835-0s7ok4uw	5052	28	of	of	IN
cord-001835-0s7ok4uw	5052	29	interfacial	interfacial	JJ
cord-001835-0s7ok4uw	5052	30	contacts	contact	NNS
cord-001835-0s7ok4uw	5052	31	.	.	.
cord-001835-0s7ok4uw	5053	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5053	2	assess	assess	VBP
cord-001835-0s7ok4uw	5053	3	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5053	4	performance	performance	NN
cord-001835-0s7ok4uw	5053	5	against	against	IN
cord-001835-0s7ok4uw	5053	6	a	a	DT
cord-001835-0s7ok4uw	5053	7	protein	protein	NN
cord-001835-0s7ok4uw	5053	8	-	-	HYPH
cord-001835-0s7ok4uw	5053	9	protein	protein	NN
cord-001835-0s7ok4uw	5053	10	binding	bind	VBG
cord-001835-0s7ok4uw	5053	11	affinity	affinity	NN
cord-001835-0s7ok4uw	5053	12	benchmark	benchmark	NN
cord-001835-0s7ok4uw	5053	13	and	and	CC
cord-001835-0s7ok4uw	5053	14	show	show	VB
cord-001835-0s7ok4uw	5053	15	that	that	IN
cord-001835-0s7ok4uw	5053	16	both	both	CC
cord-001835-0s7ok4uw	5053	17	experimental	experimental	JJ
cord-001835-0s7ok4uw	5053	18	methods	method	NNS
cord-001835-0s7ok4uw	5053	19	used	use	VBN
cord-001835-0s7ok4uw	5053	20	for	for	IN
cord-001835-0s7ok4uw	5053	21	affinity	affinity	NN
cord-001835-0s7ok4uw	5053	22	measurements	measurement	NNS
cord-001835-0s7ok4uw	5053	23	and	and	CC
cord-001835-0s7ok4uw	5053	24	conformational	conformational	JJ
cord-001835-0s7ok4uw	5053	25	changes	change	NNS
cord-001835-0s7ok4uw	5053	26	have	have	VBP
cord-001835-0s7ok4uw	5053	27	a	a	DT
cord-001835-0s7ok4uw	5053	28	strong	strong	JJ
cord-001835-0s7ok4uw	5053	29	impact	impact	NN
cord-001835-0s7ok4uw	5053	30	on	on	IN
cord-001835-0s7ok4uw	5053	31	prediction	prediction	NN
cord-001835-0s7ok4uw	5053	32	accuracy	accuracy	NN
cord-001835-0s7ok4uw	5053	33	.	.	.
cord-001835-0s7ok4uw	5054	1	Using	use	VBG
cord-001835-0s7ok4uw	5054	2	a	a	DT
cord-001835-0s7ok4uw	5054	3	subset	subset	NN
cord-001835-0s7ok4uw	5054	4	of	of	IN
cord-001835-0s7ok4uw	5054	5	complexes	complex	NNS
cord-001835-0s7ok4uw	5054	6	with	with	IN
cord-001835-0s7ok4uw	5054	7	reliable	reliable	JJ
cord-001835-0s7ok4uw	5054	8	experimental	experimental	JJ
cord-001835-0s7ok4uw	5054	9	binding	bind	VBG
cord-001835-0s7ok4uw	5054	10	affinities	affinity	NNS
cord-001835-0s7ok4uw	5054	11	and	and	CC
cord-001835-0s7ok4uw	5054	12	combining	combine	VBG
cord-001835-0s7ok4uw	5054	13	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5054	14	contacts	contact	NNS
cord-001835-0s7ok4uw	5054	15	-	-	:
cord-001835-0s7ok4uw	5054	16	and	and	CC
cord-001835-0s7ok4uw	5054	17	contact	contact	NN
cord-001835-0s7ok4uw	5054	18	types	type	NNS
cord-001835-0s7ok4uw	5054	19	-	-	HYPH
cord-001835-0s7ok4uw	5054	20	based	base	VBN
cord-001835-0s7ok4uw	5054	21	model	model	NN
cord-001835-0s7ok4uw	5054	22	with	with	IN
cord-001835-0s7ok4uw	5054	23	recent	recent	JJ
cord-001835-0s7ok4uw	5054	24	observations	observation	NNS
cord-001835-0s7ok4uw	5054	25	on	on	IN
cord-001835-0s7ok4uw	5054	26	the	the	DT
cord-001835-0s7ok4uw	5054	27	role	role	NN
cord-001835-0s7ok4uw	5054	28	of	of	IN
cord-001835-0s7ok4uw	5054	29	the	the	DT
cord-001835-0s7ok4uw	5054	30	non	non	NN
cord-001835-0s7ok4uw	5054	31	-	-	JJ
cord-001835-0s7ok4uw	5054	32	interacting	interacting	JJ
cord-001835-0s7ok4uw	5054	33	surface	surface	NN
cord-001835-0s7ok4uw	5054	34	in	in	IN
cord-001835-0s7ok4uw	5054	35	protein	protein	NN
cord-001835-0s7ok4uw	5054	36	-	-	HYPH
cord-001835-0s7ok4uw	5054	37	protein	protein	NN
cord-001835-0s7ok4uw	5054	38	interactions	interaction	NNS
cord-001835-0s7ok4uw	5054	39	,	,	,
cord-001835-0s7ok4uw	5054	40	we	-PRON-	PRP
cord-001835-0s7ok4uw	5054	41	reach	reach	VBP
cord-001835-0s7ok4uw	5054	42	a	a	DT
cord-001835-0s7ok4uw	5054	43	high	high	JJ
cord-001835-0s7ok4uw	5054	44	prediction	prediction	NN
cord-001835-0s7ok4uw	5054	45	accuracy	accuracy	NN
cord-001835-0s7ok4uw	5054	46	for	for	IN
cord-001835-0s7ok4uw	5054	47	such	such	PDT
cord-001835-0s7ok4uw	5054	48	a	a	DT
cord-001835-0s7ok4uw	5054	49	diverse	diverse	JJ
cord-001835-0s7ok4uw	5054	50	dataset	dataset	NN
cord-001835-0s7ok4uw	5054	51	outperforming	outperform	VBG
cord-001835-0s7ok4uw	5054	52	all	all	DT
cord-001835-0s7ok4uw	5054	53	other	other	JJ
cord-001835-0s7ok4uw	5054	54	tested	test	VBN
cord-001835-0s7ok4uw	5054	55	methods	method	NNS
cord-001835-0s7ok4uw	5054	56	.	.	.
cord-001835-0s7ok4uw	5055	1	Free	free	JJ
cord-001835-0s7ok4uw	5055	2	radical	radical	JJ
cord-001835-0s7ok4uw	5055	3	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5055	4	-a	-a	.
cord-001835-0s7ok4uw	5056	1	new	new	JJ
cord-001835-0s7ok4uw	5056	2	method	method	NN
cord-001835-0s7ok4uw	5056	3	for	for	IN
cord-001835-0s7ok4uw	5056	4	obtaining	obtain	VBG
cord-001835-0s7ok4uw	5056	5	stable	stable	JJ
cord-001835-0s7ok4uw	5056	6	protein	protein	NN
cord-001835-0s7ok4uw	5056	7	coatings	coating	NNS
cord-001835-0s7ok4uw	5056	8	on	on	IN
cord-001835-0s7ok4uw	5056	9	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	5056	10	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	5056	11	Magnetically	magnetically	RB
cord-001835-0s7ok4uw	5056	12	targeted	target	VBN
cord-001835-0s7ok4uw	5056	13	nanosystems	nanosystem	NNS
cord-001835-0s7ok4uw	5056	14	(	(	-LRB-
cord-001835-0s7ok4uw	5056	15	MTNSs	MTNSs	NNP
cord-001835-0s7ok4uw	5056	16	)	)	-RRB-
cord-001835-0s7ok4uw	5056	17	are	be	VBP
cord-001835-0s7ok4uw	5056	18	now	now	RB
cord-001835-0s7ok4uw	5056	19	considered	consider	VBN
cord-001835-0s7ok4uw	5056	20	to	to	TO
cord-001835-0s7ok4uw	5056	21	be	be	VB
cord-001835-0s7ok4uw	5056	22	applicable	applicable	JJ
cord-001835-0s7ok4uw	5056	23	in	in	IN
cord-001835-0s7ok4uw	5056	24	different	different	JJ
cord-001835-0s7ok4uw	5056	25	areas	area	NNS
cord-001835-0s7ok4uw	5056	26	of	of	IN
cord-001835-0s7ok4uw	5056	27	biology	biology	NN
cord-001835-0s7ok4uw	5056	28	and	and	CC
cord-001835-0s7ok4uw	5056	29	medicine	medicine	NN
cord-001835-0s7ok4uw	5056	30	such	such	JJ
cord-001835-0s7ok4uw	5056	31	as	as	IN
cord-001835-0s7ok4uw	5056	32	hyperthermia	hyperthermia	NN
cord-001835-0s7ok4uw	5056	33	,	,	,
cord-001835-0s7ok4uw	5056	34	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	5056	35	resonance	resonance	NN
cord-001835-0s7ok4uw	5056	36	imaging	imaging	NN
cord-001835-0s7ok4uw	5056	37	,	,	,
cord-001835-0s7ok4uw	5056	38	immunoassay	immunoassay	NN
cord-001835-0s7ok4uw	5056	39	,	,	,
cord-001835-0s7ok4uw	5056	40	cell	cell	NN
cord-001835-0s7ok4uw	5056	41	and	and	CC
cord-001835-0s7ok4uw	5056	42	molecular	molecular	JJ
cord-001835-0s7ok4uw	5056	43	separation	separation	NN
cord-001835-0s7ok4uw	5056	44	,	,	,
cord-001835-0s7ok4uw	5056	45	a	a	DT
cord-001835-0s7ok4uw	5056	46	smart	smart	JJ
cord-001835-0s7ok4uw	5056	47	delivery	delivery	NN
cord-001835-0s7ok4uw	5056	48	of	of	IN
cord-001835-0s7ok4uw	5056	49	drugs	drug	NNS
cord-001835-0s7ok4uw	5056	50	to	to	TO
cord-001835-0s7ok4uw	5056	51	target	target	VB
cord-001835-0s7ok4uw	5056	52	cells	cell	NNS
cord-001835-0s7ok4uw	5056	53	.	.	.
cord-001835-0s7ok4uw	5057	1	Proteins	protein	NNS
cord-001835-0s7ok4uw	5057	2	are	be	VBP
cord-001835-0s7ok4uw	5057	3	promising	promise	VBG
cord-001835-0s7ok4uw	5057	4	materials	material	NNS
cord-001835-0s7ok4uw	5057	5	for	for	IN
cord-001835-0s7ok4uw	5057	6	creation	creation	NN
cord-001835-0s7ok4uw	5057	7	of	of	IN
cord-001835-0s7ok4uw	5057	8	coatings	coating	NNS
cord-001835-0s7ok4uw	5057	9	on	on	IN
cord-001835-0s7ok4uw	5057	10	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	5057	11	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	5057	12	(	(	-LRB-
cord-001835-0s7ok4uw	5057	13	MNPs	MNPs	NNP
cord-001835-0s7ok4uw	5057	14	)	)	-RRB-
cord-001835-0s7ok4uw	5057	15	due	due	IN
cord-001835-0s7ok4uw	5057	16	to	to	IN
cord-001835-0s7ok4uw	5057	17	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5057	18	biocompatibility	biocompatibility	NN
cord-001835-0s7ok4uw	5057	19	,	,	,
cord-001835-0s7ok4uw	5057	20	an	an	DT
cord-001835-0s7ok4uw	5057	21	ability	ability	NN
cord-001835-0s7ok4uw	5057	22	to	to	TO
cord-001835-0s7ok4uw	5057	23	protect	protect	VB
cord-001835-0s7ok4uw	5057	24	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	5057	25	cores	core	NNS
cord-001835-0s7ok4uw	5057	26	from	from	IN
cord-001835-0s7ok4uw	5057	27	influence	influence	NN
cord-001835-0s7ok4uw	5057	28	of	of	IN
cord-001835-0s7ok4uw	5057	29	biological	biological	JJ
cord-001835-0s7ok4uw	5057	30	liquids	liquid	NNS
cord-001835-0s7ok4uw	5057	31	and	and	CC
cord-001835-0s7ok4uw	5057	32	prevent	prevent	VBP
cord-001835-0s7ok4uw	5057	33	agglomeration	agglomeration	NN
cord-001835-0s7ok4uw	5057	34	of	of	IN
cord-001835-0s7ok4uw	5057	35	MTNSs	MTNSs	NNPS
cord-001835-0s7ok4uw	5057	36	in	in	IN
cord-001835-0s7ok4uw	5057	37	dispersion	dispersion	NN
cord-001835-0s7ok4uw	5057	38	,	,	,
cord-001835-0s7ok4uw	5057	39	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5057	40	possible	possible	JJ
cord-001835-0s7ok4uw	5057	41	functional	functional	JJ
cord-001835-0s7ok4uw	5057	42	activity	activity	NN
cord-001835-0s7ok4uw	5057	43	as	as	IN
cord-001835-0s7ok4uw	5057	44	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	5057	45	products	product	NNS
cord-001835-0s7ok4uw	5057	46	and	and	CC
cord-001835-0s7ok4uw	5057	47	biovectors	biovector	NNS
cord-001835-0s7ok4uw	5057	48	.	.	.
cord-001835-0s7ok4uw	5058	1	The	the	DT
cord-001835-0s7ok4uw	5058	2	creation	creation	NN
cord-001835-0s7ok4uw	5058	3	of	of	IN
cord-001835-0s7ok4uw	5058	4	stable	stable	JJ
cord-001835-0s7ok4uw	5058	5	protein	protein	NN
cord-001835-0s7ok4uw	5058	6	coatings	coating	NNS
cord-001835-0s7ok4uw	5058	7	with	with	IN
cord-001835-0s7ok4uw	5058	8	retention	retention	NN
cord-001835-0s7ok4uw	5058	9	of	of	IN
cord-001835-0s7ok4uw	5058	10	native	native	JJ
cord-001835-0s7ok4uw	5058	11	properties	property	NNS
cord-001835-0s7ok4uw	5058	12	of	of	IN
cord-001835-0s7ok4uw	5058	13	molecules	molecule	NNS
cord-001835-0s7ok4uw	5058	14	is	be	VBZ
cord-001835-0s7ok4uw	5058	15	still	still	RB
cord-001835-0s7ok4uw	5058	16	an	an	DT
cord-001835-0s7ok4uw	5058	17	important	important	JJ
cord-001835-0s7ok4uw	5058	18	biomedical	biomedical	JJ
cord-001835-0s7ok4uw	5058	19	problem	problem	NN
cord-001835-0s7ok4uw	5058	20	because	because	IN
cord-001835-0s7ok4uw	5058	21	of	of	IN
cord-001835-0s7ok4uw	5058	22	disadvantages	disadvantage	NNS
cord-001835-0s7ok4uw	5058	23	of	of	IN
cord-001835-0s7ok4uw	5058	24	the	the	DT
cord-001835-0s7ok4uw	5058	25	commonly	commonly	RB
cord-001835-0s7ok4uw	5058	26	used	use	VBN
cord-001835-0s7ok4uw	5058	27	methods	method	NNS
cord-001835-0s7ok4uw	5058	28	such	such	JJ
cord-001835-0s7ok4uw	5058	29	as	as	IN
cord-001835-0s7ok4uw	5058	30	formation	formation	NN
cord-001835-0s7ok4uw	5058	31	of	of	IN
cord-001835-0s7ok4uw	5058	32	a	a	DT
cord-001835-0s7ok4uw	5058	33	polydisperse	polydisperse	JJ
cord-001835-0s7ok4uw	5058	34	ensemble	ensemble	NN
cord-001835-0s7ok4uw	5058	35	of	of	IN
cord-001835-0s7ok4uw	5058	36	particles	particle	NNS
cord-001835-0s7ok4uw	5058	37	,	,	,
cord-001835-0s7ok4uw	5058	38	nonselective	nonselective	JJ
cord-001835-0s7ok4uw	5058	39	linking	linking	NN
cord-001835-0s7ok4uw	5058	40	of	of	IN
cord-001835-0s7ok4uw	5058	41	proteins	protein	NNS
cord-001835-0s7ok4uw	5058	42	leading	lead	VBG
cord-001835-0s7ok4uw	5058	43	to	to	IN
cord-001835-0s7ok4uw	5058	44	cross	cross	NN
cord-001835-0s7ok4uw	5058	45	-	-	JJ
cord-001835-0s7ok4uw	5058	46	linking	linking	NN
cord-001835-0s7ok4uw	5058	47	of	of	IN
cord-001835-0s7ok4uw	5058	48	macromolecules	macromolecule	NNS
cord-001835-0s7ok4uw	5058	49	in	in	IN
cord-001835-0s7ok4uw	5058	50	solution	solution	NN
cord-001835-0s7ok4uw	5058	51	,	,	,
cord-001835-0s7ok4uw	5058	52	and	and	CC
cord-001835-0s7ok4uw	5058	53	desorption	desorption	NN
cord-001835-0s7ok4uw	5058	54	of	of	IN
cord-001835-0s7ok4uw	5058	55	coatings	coating	NNS
cord-001835-0s7ok4uw	5058	56	.	.	.
cord-001835-0s7ok4uw	5059	1	A	a	DT
cord-001835-0s7ok4uw	5059	2	novel	novel	JJ
cord-001835-0s7ok4uw	5059	3	method	method	NN
cord-001835-0s7ok4uw	5059	4	in	in	IN
cord-001835-0s7ok4uw	5059	5	obtaining	obtain	VBG
cord-001835-0s7ok4uw	5059	6	stable	stable	JJ
cord-001835-0s7ok4uw	5059	7	single	single	JJ
cord-001835-0s7ok4uw	5059	8	-	-	HYPH
cord-001835-0s7ok4uw	5059	9	layer	layer	NN
cord-001835-0s7ok4uw	5059	10	coatings	coating	NNS
cord-001835-0s7ok4uw	5059	11	assembled	assemble	VBN
cord-001835-0s7ok4uw	5059	12	from	from	IN
cord-001835-0s7ok4uw	5059	13	protein	protein	NN
cord-001835-0s7ok4uw	5059	14	molecules	molecule	NNS
cord-001835-0s7ok4uw	5059	15	on	on	IN
cord-001835-0s7ok4uw	5059	16	the	the	DT
cord-001835-0s7ok4uw	5059	17	surface	surface	NN
cord-001835-0s7ok4uw	5059	18	of	of	IN
cord-001835-0s7ok4uw	5059	19	magnetite	magnetite	NN
cord-001835-0s7ok4uw	5059	20	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	5059	21	has	have	VBZ
cord-001835-0s7ok4uw	5059	22	been	be	VBN
cord-001835-0s7ok4uw	5059	23	developed	develop	VBN
cord-001835-0s7ok4uw	5059	24	.	.	.
cord-001835-0s7ok4uw	5060	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5060	2	is	be	VBZ
cord-001835-0s7ok4uw	5060	3	based	base	VBN
cord-001835-0s7ok4uw	5060	4	on	on	IN
cord-001835-0s7ok4uw	5060	5	protein	protein	NN
cord-001835-0s7ok4uw	5060	6	liability	liability	NN
cord-001835-0s7ok4uw	5060	7	to	to	TO
cord-001835-0s7ok4uw	5060	8	free	free	VB
cord-001835-0s7ok4uw	5060	9	radical	radical	JJ
cord-001835-0s7ok4uw	5060	10	modification	modification	NN
cord-001835-0s7ok4uw	5060	11	,	,	,
cord-001835-0s7ok4uw	5060	12	leading	lead	VBG
cord-001835-0s7ok4uw	5060	13	to	to	IN
cord-001835-0s7ok4uw	5060	14	the	the	DT
cord-001835-0s7ok4uw	5060	15	formation	formation	NN
cord-001835-0s7ok4uw	5060	16	of	of	IN
cord-001835-0s7ok4uw	5060	17	intermolecular	intermolecular	NNP
cord-001835-0s7ok4uw	5060	18	covalent	covalent	JJ
cord-001835-0s7ok4uw	5060	19	cross	cross	NN
cord-001835-0s7ok4uw	5060	20	links	link	NNS
cord-001835-0s7ok4uw	5060	21	.	.	.
cord-001835-0s7ok4uw	5061	1	Free	free	JJ
cord-001835-0s7ok4uw	5061	2	radicals	radical	NNS
cord-001835-0s7ok4uw	5061	3	are	be	VBP
cord-001835-0s7ok4uw	5061	4	locally	locally	RB
cord-001835-0s7ok4uw	5061	5	generated	generate	VBN
cord-001835-0s7ok4uw	5061	6	on	on	IN
cord-001835-0s7ok4uw	5061	7	the	the	DT
cord-001835-0s7ok4uw	5061	8	surface	surface	NN
cord-001835-0s7ok4uw	5061	9	of	of	IN
cord-001835-0s7ok4uw	5061	10	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	5061	11	via	via	IN
cord-001835-0s7ok4uw	5061	12	the	the	DT
cord-001835-0s7ok4uw	5061	13	Fenton	Fenton	NNP
cord-001835-0s7ok4uw	5061	14	reaction	reaction	NN
cord-001835-0s7ok4uw	5061	15	thereby	thereby	RB
cord-001835-0s7ok4uw	5061	16	proteins	protein	NNS
cord-001835-0s7ok4uw	5061	17	adsorbed	adsorb	VBN
cord-001835-0s7ok4uw	5061	18	on	on	IN
cord-001835-0s7ok4uw	5061	19	the	the	DT
cord-001835-0s7ok4uw	5061	20	surface	surface	NN
cord-001835-0s7ok4uw	5061	21	are	be	VBP
cord-001835-0s7ok4uw	5061	22	subjected	subject	VBN
cord-001835-0s7ok4uw	5061	23	to	to	IN
cord-001835-0s7ok4uw	5061	24	the	the	DT
cord-001835-0s7ok4uw	5061	25	cross	cross	NN
cord-001835-0s7ok4uw	5061	26	-	-	JJ
cord-001835-0s7ok4uw	5061	27	linking	linking	NN
cord-001835-0s7ok4uw	5061	28	.	.	.
cord-001835-0s7ok4uw	5062	1	O	o	NN
cord-001835-0s7ok4uw	5062	2	-	-	HYPH
cord-001835-0s7ok4uw	5062	3	phenylenediamine	phenylenediamine	NN
cord-001835-0s7ok4uw	5062	4	was	be	VBD
cord-001835-0s7ok4uw	5062	5	used	use	VBN
cord-001835-0s7ok4uw	5062	6	for	for	IN
cord-001835-0s7ok4uw	5062	7	detection	detection	NN
cord-001835-0s7ok4uw	5062	8	of	of	IN
cord-001835-0s7ok4uw	5062	9	free	free	JJ
cord-001835-0s7ok4uw	5062	10	radical	radical	JJ
cord-001835-0s7ok4uw	5062	11	generation	generation	NN
cord-001835-0s7ok4uw	5062	12	initiated	initiate	VBN
cord-001835-0s7ok4uw	5062	13	by	by	IN
cord-001835-0s7ok4uw	5062	14	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	5062	15	.	.	.
cord-001835-0s7ok4uw	5063	1	The	the	DT
cord-001835-0s7ok4uw	5063	2	proteins	protein	NNS
cord-001835-0s7ok4uw	5063	3	drastically	drastically	RB
cord-001835-0s7ok4uw	5063	4	differing	differ	VBG
cord-001835-0s7ok4uw	5063	5	in	in	IN
cord-001835-0s7ok4uw	5063	6	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5063	7	structure	structure	NN
cord-001835-0s7ok4uw	5063	8	and	and	CC
cord-001835-0s7ok4uw	5063	9	properties	property	NNS
cord-001835-0s7ok4uw	5063	10	,	,	,
cord-001835-0s7ok4uw	5063	11	namely	namely	RB
cord-001835-0s7ok4uw	5063	12	,	,	,
cord-001835-0s7ok4uw	5063	13	serum	serum	NN
cord-001835-0s7ok4uw	5063	14	albumin	albumin	NN
cord-001835-0s7ok4uw	5063	15	,	,	.
cord-001835-0s7ok4uw	5064	1	thrombin	thrombin	NN
cord-001835-0s7ok4uw	5064	2	and	and	CC
cord-001835-0s7ok4uw	5064	3	immunoglobulin	immunoglobulin	NN
cord-001835-0s7ok4uw	5064	4	G	G	NNP
cord-001835-0s7ok4uw	5064	5	were	be	VBD
cord-001835-0s7ok4uw	5064	6	selected	select	VBN
cord-001835-0s7ok4uw	5064	7	for	for	IN
cord-001835-0s7ok4uw	5064	8	creating	create	VBG
cord-001835-0s7ok4uw	5064	9	the	the	DT
cord-001835-0s7ok4uw	5064	10	protein	protein	NN
cord-001835-0s7ok4uw	5064	11	coatings	coating	NNS
cord-001835-0s7ok4uw	5064	12	.	.	.
cord-001835-0s7ok4uw	5065	1	The	the	DT
cord-001835-0s7ok4uw	5065	2	properties	property	NNS
cord-001835-0s7ok4uw	5065	3	of	of	IN
cord-001835-0s7ok4uw	5065	4	the	the	DT
cord-001835-0s7ok4uw	5065	5	obtained	obtain	VBN
cord-001835-0s7ok4uw	5065	6	coatings	coating	NNS
cord-001835-0s7ok4uw	5065	7	and	and	CC
cord-001835-0s7ok4uw	5065	8	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5065	9	stability	stability	NN
cord-001835-0s7ok4uw	5065	10	have	have	VBP
cord-001835-0s7ok4uw	5065	11	been	be	VBN
cord-001835-0s7ok4uw	5065	12	studied	study	VBN
cord-001835-0s7ok4uw	5065	13	with	with	IN
cord-001835-0s7ok4uw	5065	14	the	the	DT
cord-001835-0s7ok4uw	5065	15	help	help	NN
cord-001835-0s7ok4uw	5065	16	of	of	IN
cord-001835-0s7ok4uw	5065	17	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	5065	18	light	light	JJ
cord-001835-0s7ok4uw	5065	19	scattering	scattering	NN
cord-001835-0s7ok4uw	5065	20	(	(	-LRB-
cord-001835-0s7ok4uw	5065	21	DLS	DLS	NNP
cord-001835-0s7ok4uw	5065	22	)	)	-RRB-
cord-001835-0s7ok4uw	5065	23	,	,	,
cord-001835-0s7ok4uw	5065	24	UV	UV	NNP
cord-001835-0s7ok4uw	5065	25	/	/	SYM
cord-001835-0s7ok4uw	5065	26	Vis	Vis	NNP
cord-001835-0s7ok4uw	5065	27	spectrophotometry	spectrophotometry	NN
cord-001835-0s7ok4uw	5065	28	,	,	,
cord-001835-0s7ok4uw	5065	29	antibody	antibody	NN
cord-001835-0s7ok4uw	5065	30	-	-	HYPH
cord-001835-0s7ok4uw	5065	31	antigen	antigen	NN
cord-001835-0s7ok4uw	5065	32	test	test	NN
cord-001835-0s7ok4uw	5065	33	and	and	CC
cord-001835-0s7ok4uw	5065	34	the	the	DT
cord-001835-0s7ok4uw	5065	35	method	method	NN
cord-001835-0s7ok4uw	5065	36	of	of	IN
cord-001835-0s7ok4uw	5065	37	spectral	spectral	JJ
cord-001835-0s7ok4uw	5065	38	-	-	HYPH
cord-001835-0s7ok4uw	5065	39	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	5065	40	probes	probe	NNS
cord-001835-0s7ok4uw	5065	41	.	.	.
cord-001835-0s7ok4uw	5066	1	Albumin	albumin	NN
cord-001835-0s7ok4uw	5066	2	molecules	molecule	NNS
cord-001835-0s7ok4uw	5066	3	in	in	IN
cord-001835-0s7ok4uw	5066	4	MNPs	mnps	JJ
cord-001835-0s7ok4uw	5066	5	coatings	coating	NNS
cord-001835-0s7ok4uw	5066	6	have	have	VBP
cord-001835-0s7ok4uw	5066	7	been	be	VBN
cord-001835-0s7ok4uw	5066	8	shown	show	VBN
cord-001835-0s7ok4uw	5066	9	to	to	TO
cord-001835-0s7ok4uw	5066	10	retain	retain	VB
cord-001835-0s7ok4uw	5066	11	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5066	12	capability	capability	NN
cord-001835-0s7ok4uw	5066	13	of	of	IN
cord-001835-0s7ok4uw	5066	14	binding	bind	VBG
cord-001835-0s7ok4uw	5066	15	with	with	IN
cord-001835-0s7ok4uw	5066	16	a	a	DT
cord-001835-0s7ok4uw	5066	17	dye	dye	NN
cord-001835-0s7ok4uw	5066	18	and	and	CC
cord-001835-0s7ok4uw	5066	19	be	be	VB
cord-001835-0s7ok4uw	5066	20	conformationally	conformationally	RB
cord-001835-0s7ok4uw	5066	21	stable	stable	JJ
cord-001835-0s7ok4uw	5066	22	.	.	.
cord-001835-0s7ok4uw	5067	1	The	the	DT
cord-001835-0s7ok4uw	5067	2	dye	dye	NN
cord-001835-0s7ok4uw	5067	3	3,3'-di-(g	3,3'-di-(g	CD
cord-001835-0s7ok4uw	5067	4	-	-	HYPH
cord-001835-0s7ok4uw	5067	5	sulfopropyl)25,5'diphenyl-9-ethiloxacarbocyanine	sulfopropyl)25,5'diphenyl-9-ethiloxacarbocyanine	NN
cord-001835-0s7ok4uw	5067	6	-	-	HYPH
cord-001835-0s7ok4uw	5067	7	betaine	betaine	NN
cord-001835-0s7ok4uw	5067	8	interacting	interact	VBG
cord-001835-0s7ok4uw	5067	9	with	with	IN
cord-001835-0s7ok4uw	5067	10	albumin	albumin	NN
cord-001835-0s7ok4uw	5067	11	with	with	IN
cord-001835-0s7ok4uw	5067	12	a	a	DT
cord-001835-0s7ok4uw	5067	13	growth	growth	NN
cord-001835-0s7ok4uw	5067	14	of	of	IN
cord-001835-0s7ok4uw	5067	15	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	5067	16	and	and	CC
cord-001835-0s7ok4uw	5067	17	with	with	IN
cord-001835-0s7ok4uw	5067	18	partial	partial	JJ
cord-001835-0s7ok4uw	5067	19	cis	cis	NNP
cord-001835-0s7ok4uw	5067	20	-	-	HYPH
cord-001835-0s7ok4uw	5067	21	trans	trans	NNP
cord-001835-0s7ok4uw	5067	22	conversion	conversion	NN
cord-001835-0s7ok4uw	5067	23	of	of	IN
cord-001835-0s7ok4uw	5067	24	the	the	DT
cord-001835-0s7ok4uw	5067	25	dye	dye	NN
cord-001835-0s7ok4uw	5067	26	has	have	VBZ
cord-001835-0s7ok4uw	5067	27	been	be	VBN
cord-001835-0s7ok4uw	5067	28	used	use	VBN
cord-001835-0s7ok4uw	5067	29	.	.	.
cord-001835-0s7ok4uw	5068	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5068	2	has	have	VBZ
cord-001835-0s7ok4uw	5068	3	been	be	VBN
cord-001835-0s7ok4uw	5068	4	proven	prove	VBN
cord-001835-0s7ok4uw	5068	5	that	that	IN
cord-001835-0s7ok4uw	5068	6	coatings	coating	NNS
cord-001835-0s7ok4uw	5068	7	composed	compose	VBN
cord-001835-0s7ok4uw	5068	8	of	of	IN
cord-001835-0s7ok4uw	5068	9	protein	protein	NN
cord-001835-0s7ok4uw	5068	10	macromolecules	macromolecule	NNS
cord-001835-0s7ok4uw	5068	11	are	be	VBP
cord-001835-0s7ok4uw	5068	12	1	1	CD
cord-001835-0s7ok4uw	5068	13	)	)	-RRB-
cord-001835-0s7ok4uw	5068	14	stable	stable	JJ
cord-001835-0s7ok4uw	5068	15	,	,	,
cord-001835-0s7ok4uw	5068	16	2	2	CD
cord-001835-0s7ok4uw	5068	17	)	)	-RRB-
cord-001835-0s7ok4uw	5068	18	formed	form	VBN
cord-001835-0s7ok4uw	5068	19	around	around	IN
cord-001835-0s7ok4uw	5068	20	individual	individual	JJ
cord-001835-0s7ok4uw	5068	21	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	5068	22	and	and	CC
cord-001835-0s7ok4uw	5068	23	3	3	LS
cord-001835-0s7ok4uw	5068	24	)	)	-RRB-
cord-001835-0s7ok4uw	5068	25	have	have	VBP
cord-001835-0s7ok4uw	5068	26	several	several	JJ
cord-001835-0s7ok4uw	5068	27	nanometers	nanometer	NNS
cord-001835-0s7ok4uw	5068	28	in	in	IN
cord-001835-0s7ok4uw	5068	29	thickness	thickness	NN
cord-001835-0s7ok4uw	5068	30	.	.	.
cord-001835-0s7ok4uw	5069	1	The	the	DT
cord-001835-0s7ok4uw	5069	2	free	free	JJ
cord-001835-0s7ok4uw	5069	3	radical	radical	JJ
cord-001835-0s7ok4uw	5069	4	linking	linking	NN
cord-001835-0s7ok4uw	5069	5	of	of	IN
cord-001835-0s7ok4uw	5069	6	thrombin	thrombin	NN
cord-001835-0s7ok4uw	5069	7	and	and	CC
cord-001835-0s7ok4uw	5069	8	immunoglobulin	immunoglobulin	NN
cord-001835-0s7ok4uw	5069	9	G	g	NN
cord-001835-0s7ok4uw	5069	10	on	on	IN
cord-001835-0s7ok4uw	5069	11	the	the	DT
cord-001835-0s7ok4uw	5069	12	surface	surface	NN
cord-001835-0s7ok4uw	5069	13	of	of	IN
cord-001835-0s7ok4uw	5069	14	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	5069	15	has	have	VBZ
cord-001835-0s7ok4uw	5069	16	been	be	VBN
cord-001835-0s7ok4uw	5069	17	shown	show	VBN
cord-001835-0s7ok4uw	5069	18	to	to	IN
cord-001835-0s7ok4uw	5069	19	almost	almost	RB
cord-001835-0s7ok4uw	5069	20	completely	completely	RB
cord-001835-0s7ok4uw	5069	21	keep	keep	VB
cord-001835-0s7ok4uw	5069	22	native	native	JJ
cord-001835-0s7ok4uw	5069	23	properties	property	NNS
cord-001835-0s7ok4uw	5069	24	of	of	IN
cord-001835-0s7ok4uw	5069	25	the	the	DT
cord-001835-0s7ok4uw	5069	26	protein	protein	NN
cord-001835-0s7ok4uw	5069	27	molecules	molecule	NNS
cord-001835-0s7ok4uw	5069	28	.	.	.
cord-001835-0s7ok4uw	5070	1	The	the	DT
cord-001835-0s7ok4uw	5070	2	free	free	JJ
cord-001835-0s7ok4uw	5070	3	radical	radical	JJ
cord-001835-0s7ok4uw	5070	4	linking	linking	NN
cord-001835-0s7ok4uw	5070	5	method	method	NN
cord-001835-0s7ok4uw	5070	6	reveals	reveal	VBZ
cord-001835-0s7ok4uw	5070	7	new	new	JJ
cord-001835-0s7ok4uw	5070	8	possibilities	possibility	NNS
cord-001835-0s7ok4uw	5070	9	for	for	IN
cord-001835-0s7ok4uw	5070	10	design	design	NN
cord-001835-0s7ok4uw	5070	11	of	of	IN
cord-001835-0s7ok4uw	5070	12	single	single	JJ
cord-001835-0s7ok4uw	5070	13	-	-	HYPH
cord-001835-0s7ok4uw	5070	14	layer	layer	NN
cord-001835-0s7ok4uw	5070	15	multiprotein	multiprotein	NNP
cord-001835-0s7ok4uw	5070	16	polyfunctional	polyfunctional	NNP
cord-001835-0s7ok4uw	5070	17	coatings	coating	NNS
cord-001835-0s7ok4uw	5070	18	on	on	IN
cord-001835-0s7ok4uw	5070	19	the	the	DT
cord-001835-0s7ok4uw	5070	20	surfaces	surface	NNS
cord-001835-0s7ok4uw	5070	21	of	of	IN
cord-001835-0s7ok4uw	5070	22	all	all	PDT
cord-001835-0s7ok4uw	5070	23	the	the	DT
cord-001835-0s7ok4uw	5070	24	nano-	nano-	NN
cord-001835-0s7ok4uw	5070	25	,	,	,
cord-001835-0s7ok4uw	5070	26	micro	micro	NN
cord-001835-0s7ok4uw	5070	27	-	-	HYPH
cord-001835-0s7ok4uw	5070	28	and	and	CC
cord-001835-0s7ok4uw	5070	29	macroobjects	macroobjects	VBP
cord-001835-0s7ok4uw	5070	30	containing	contain	VBG
cord-001835-0s7ok4uw	5070	31	metals	metal	NNS
cord-001835-0s7ok4uw	5070	32	of	of	IN
cord-001835-0s7ok4uw	5070	33	variable	variable	JJ
cord-001835-0s7ok4uw	5070	34	valence	valence	NN
cord-001835-0s7ok4uw	5070	35	(	(	-LRB-
cord-001835-0s7ok4uw	5070	36	for	for	IN
cord-001835-0s7ok4uw	5070	37	example	example	NN
cord-001835-0s7ok4uw	5070	38	,	,	,
cord-001835-0s7ok4uw	5070	39	Fe	Fe	NNP
cord-001835-0s7ok4uw	5070	40	,	,	,
cord-001835-0s7ok4uw	5070	41	Cu	Cu	NNP
cord-001835-0s7ok4uw	5070	42	,	,	,
cord-001835-0s7ok4uw	5070	43	Cr	Cr	NNP
cord-001835-0s7ok4uw	5070	44	)	)	-RRB-
cord-001835-0s7ok4uw	5070	45	.	.	.
cord-001835-0s7ok4uw	5071	1	The	the	DT
cord-001835-0s7ok4uw	5071	2	spectral	spectral	JJ
cord-001835-0s7ok4uw	5071	3	-	-	HYPH
cord-001835-0s7ok4uw	5071	4	fluorescent	fluorescent	JJ
cord-001835-0s7ok4uw	5071	5	investigation	investigation	NN
cord-001835-0s7ok4uw	5071	6	was	be	VBD
cord-001835-0s7ok4uw	5071	7	supported	support	VBN
cord-001835-0s7ok4uw	5071	8	by	by	IN
cord-001835-0s7ok4uw	5071	9	the	the	DT
cord-001835-0s7ok4uw	5071	10	Russian	Russian	NNP
cord-001835-0s7ok4uw	5071	11	Foundation	Foundation	NNP
cord-001835-0s7ok4uw	5071	12	for	for	IN
cord-001835-0s7ok4uw	5071	13	Basic	Basic	NNP
cord-001835-0s7ok4uw	5071	14	Research	Research	NNP
cord-001835-0s7ok4uw	5071	15	,	,	,
cord-001835-0s7ok4uw	5071	16	project	project	NN
cord-001835-0s7ok4uw	5071	17	nos	nos	NNP
cord-001835-0s7ok4uw	5071	18	.	.	.
cord-001835-0s7ok4uw	5072	1	13	13	CD
cord-001835-0s7ok4uw	5072	2	-	-	HYPH
cord-001835-0s7ok4uw	5072	3	03	03	CD
cord-001835-0s7ok4uw	5072	4	-	-	HYPH
cord-001835-0s7ok4uw	5072	5	00863	00863	CD
cord-001835-0s7ok4uw	5073	1	and	and	CC
cord-001835-0s7ok4uw	5073	2	14	14	CD
cord-001835-0s7ok4uw	5073	3	-	-	HYPH
cord-001835-0s7ok4uw	5073	4	03	03	CD
cord-001835-0s7ok4uw	5073	5	-	-	HYPH
cord-001835-0s7ok4uw	5073	6	31196mol_a	31196mol_a	CD
cord-001835-0s7ok4uw	5073	7	.	.	.
cord-001835-0s7ok4uw	5074	1	Regulation	regulation	NN
cord-001835-0s7ok4uw	5074	2	of	of	IN
cord-001835-0s7ok4uw	5074	3	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	5074	4	SNAREs	snare	NNS
cord-001835-0s7ok4uw	5074	5	by	by	IN
cord-001835-0s7ok4uw	5074	6	accessory	accessory	NN
cord-001835-0s7ok4uw	5074	7	proteins	protein	NNS
cord-001835-0s7ok4uw	5074	8	Shrutee	Shrutee	NNP
cord-001835-0s7ok4uw	5074	9	Jakhanwal	Jakhanwal	NNP
cord-001835-0s7ok4uw	5074	10	1	1	CD
cord-001835-0s7ok4uw	5074	11	,	,	,
cord-001835-0s7ok4uw	5074	12	Reinhard	Reinhard	NNP
cord-001835-0s7ok4uw	5074	13	Jahn	Jahn	NNP
cord-001835-0s7ok4uw	5074	14	1	1	CD
cord-001835-0s7ok4uw	5074	15	1	1	CD
cord-001835-0s7ok4uw	5074	16	Regulation	Regulation	NNP
cord-001835-0s7ok4uw	5074	17	of	of	IN
cord-001835-0s7ok4uw	5074	18	Neuronal	neuronal	JJ
cord-001835-0s7ok4uw	5074	19	SNAREs	snare	NNS
cord-001835-0s7ok4uw	5074	20	by	by	IN
cord-001835-0s7ok4uw	5074	21	accessory	accessory	NN
cord-001835-0s7ok4uw	5074	22	proteins	protein	NNS
cord-001835-0s7ok4uw	5075	1	1Shrutee	1shrutee	LS
cord-001835-0s7ok4uw	5076	1	Jakhanwal	Jakhanwal	NNP
cord-001835-0s7ok4uw	5076	2	and	and	CC
cord-001835-0s7ok4uw	5076	3	1Reinhard	1Reinhard	NNP
cord-001835-0s7ok4uw	5076	4	Jahn	Jahn	NNP
cord-001835-0s7ok4uw	5076	5	1Department	1Department	NNP
cord-001835-0s7ok4uw	5076	6	of	of	IN
cord-001835-0s7ok4uw	5076	7	Neurobiology	Neurobiology	NNP
cord-001835-0s7ok4uw	5076	8	,	,	,
cord-001835-0s7ok4uw	5076	9	Max	Max	NNP
cord-001835-0s7ok4uw	5076	10	Planck	Planck	NNP
cord-001835-0s7ok4uw	5076	11	Institute	Institute	NNP
cord-001835-0s7ok4uw	5076	12	of	of	IN
cord-001835-0s7ok4uw	5076	13	Biophysical	Biophysical	NNP
cord-001835-0s7ok4uw	5076	14	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	5076	15	,	,	,
cord-001835-0s7ok4uw	5076	16	Fassberg	Fassberg	NNP
cord-001835-0s7ok4uw	5076	17	,	,	,
cord-001835-0s7ok4uw	5076	18	Goettingen	Goettingen	NNP
cord-001835-0s7ok4uw	5076	19	,	,	,
cord-001835-0s7ok4uw	5076	20	Germany-37075	Germany-37075	NNP
cord-001835-0s7ok4uw	5076	21	.	.	.
cord-001835-0s7ok4uw	5077	1	Synaptic	synaptic	JJ
cord-001835-0s7ok4uw	5077	2	vesicle	vesicle	NN
cord-001835-0s7ok4uw	5077	3	exocytosis	exocytosis	NN
cord-001835-0s7ok4uw	5077	4	lies	lie	VBZ
cord-001835-0s7ok4uw	5077	5	at	at	IN
cord-001835-0s7ok4uw	5077	6	the	the	DT
cord-001835-0s7ok4uw	5077	7	heart	heart	NN
cord-001835-0s7ok4uw	5077	8	of	of	IN
cord-001835-0s7ok4uw	5077	9	the	the	DT
cord-001835-0s7ok4uw	5077	10	process	process	NN
cord-001835-0s7ok4uw	5077	11	of	of	IN
cord-001835-0s7ok4uw	5077	12	neurotransmitter	neurotransmitter	NN
cord-001835-0s7ok4uw	5077	13	release	release	NN
cord-001835-0s7ok4uw	5077	14	.	.	.
cord-001835-0s7ok4uw	5078	1	And	and	CC
cord-001835-0s7ok4uw	5078	2	,	,	,
cord-001835-0s7ok4uw	5078	3	the	the	DT
cord-001835-0s7ok4uw	5078	4	family	family	NN
cord-001835-0s7ok4uw	5078	5	of	of	IN
cord-001835-0s7ok4uw	5078	6	proteins	protein	NNS
cord-001835-0s7ok4uw	5078	7	that	that	WDT
cord-001835-0s7ok4uw	5078	8	is	be	VBZ
cord-001835-0s7ok4uw	5078	9	central	central	JJ
cord-001835-0s7ok4uw	5078	10	to	to	IN
cord-001835-0s7ok4uw	5078	11	the	the	DT
cord-001835-0s7ok4uw	5078	12	process	process	NN
cord-001835-0s7ok4uw	5078	13	of	of	IN
cord-001835-0s7ok4uw	5078	14	synaptic	synaptic	JJ
cord-001835-0s7ok4uw	5078	15	vesicle	vesicle	NN
cord-001835-0s7ok4uw	5078	16	exocytosis	exocytosis	NN
cord-001835-0s7ok4uw	5078	17	is	be	VBZ
cord-001835-0s7ok4uw	5078	18	the	the	DT
cord-001835-0s7ok4uw	5078	19	family	family	NN
cord-001835-0s7ok4uw	5078	20	of	of	IN
cord-001835-0s7ok4uw	5078	21	SNARE	snare	NN
cord-001835-0s7ok4uw	5078	22	proteins	protein	NNS
cord-001835-0s7ok4uw	5078	23	.	.	.
cord-001835-0s7ok4uw	5079	1	There	there	EX
cord-001835-0s7ok4uw	5079	2	are	be	VBP
cord-001835-0s7ok4uw	5079	3	three	three	CD
cord-001835-0s7ok4uw	5079	4	kind	kind	NN
cord-001835-0s7ok4uw	5079	5	of	of	IN
cord-001835-0s7ok4uw	5079	6	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	5079	7	SNARE	snare	NN
cord-001835-0s7ok4uw	5079	8	proteins	protein	NNS
cord-001835-0s7ok4uw	5079	9	namely	namely	RB
cord-001835-0s7ok4uw	5079	10	Syntaxin	Syntaxin	NNP
cord-001835-0s7ok4uw	5079	11	,	,	,
cord-001835-0s7ok4uw	5079	12	SNAP25	SNAP25	NNP
cord-001835-0s7ok4uw	5079	13	and	and	CC
cord-001835-0s7ok4uw	5079	14	Synaptobrevin	Synaptobrevin	NNP
cord-001835-0s7ok4uw	5079	15	.	.	.
cord-001835-0s7ok4uw	5080	1	These	these	DT
cord-001835-0s7ok4uw	5080	2	three	three	CD
cord-001835-0s7ok4uw	5080	3	SNARE	snare	NN
cord-001835-0s7ok4uw	5080	4	proteins	protein	NNS
cord-001835-0s7ok4uw	5080	5	interact	interact	VBP
cord-001835-0s7ok4uw	5080	6	through	through	IN
cord-001835-0s7ok4uw	5080	7	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5080	8	SNARE	snare	NN
cord-001835-0s7ok4uw	5080	9	-	-	HYPH
cord-001835-0s7ok4uw	5080	10	motifs	motif	NNS
cord-001835-0s7ok4uw	5080	11	to	to	TO
cord-001835-0s7ok4uw	5080	12	form	form	VB
cord-001835-0s7ok4uw	5080	13	a	a	DT
cord-001835-0s7ok4uw	5080	14	highly	highly	RB
cord-001835-0s7ok4uw	5080	15	stable	stable	JJ
cord-001835-0s7ok4uw	5080	16	four	four	CD
cord-001835-0s7ok4uw	5080	17	-	-	HYPH
cord-001835-0s7ok4uw	5080	18	helix	helix	NN
cord-001835-0s7ok4uw	5080	19	bundle	bundle	NN
cord-001835-0s7ok4uw	5080	20	,	,	,
cord-001835-0s7ok4uw	5080	21	which	which	WDT
cord-001835-0s7ok4uw	5080	22	in	in	IN
cord-001835-0s7ok4uw	5080	23	turn	turn	NN
cord-001835-0s7ok4uw	5080	24	,	,	,
cord-001835-0s7ok4uw	5080	25	pulls	pull	VBZ
cord-001835-0s7ok4uw	5080	26	two	two	CD
cord-001835-0s7ok4uw	5080	27	membranes	membrane	NNS
cord-001835-0s7ok4uw	5080	28	together	together	RB
cord-001835-0s7ok4uw	5080	29	to	to	TO
cord-001835-0s7ok4uw	5080	30	mediate	mediate	VB
cord-001835-0s7ok4uw	5080	31	fusion	fusion	NN
cord-001835-0s7ok4uw	5080	32	.	.	.
cord-001835-0s7ok4uw	5081	1	Years	year	NNS
cord-001835-0s7ok4uw	5081	2	of	of	IN
cord-001835-0s7ok4uw	5081	3	work	work	NN
cord-001835-0s7ok4uw	5081	4	in	in	IN
cord-001835-0s7ok4uw	5081	5	this	this	DT
cord-001835-0s7ok4uw	5081	6	field	field	NN
cord-001835-0s7ok4uw	5081	7	have	have	VBP
cord-001835-0s7ok4uw	5081	8	established	establish	VBN
cord-001835-0s7ok4uw	5081	9	that	that	IN
cord-001835-0s7ok4uw	5081	10	the	the	DT
cord-001835-0s7ok4uw	5081	11	four	four	CD
cord-001835-0s7ok4uw	5081	12	-	-	HYPH
cord-001835-0s7ok4uw	5081	13	helix	helix	NN
cord-001835-0s7ok4uw	5081	14	bundle	bundle	NN
cord-001835-0s7ok4uw	5081	15	is	be	VBZ
cord-001835-0s7ok4uw	5081	16	critical	critical	JJ
cord-001835-0s7ok4uw	5081	17	for	for	IN
cord-001835-0s7ok4uw	5081	18	the	the	DT
cord-001835-0s7ok4uw	5081	19	membrane	membrane	NN
cord-001835-0s7ok4uw	5081	20	fusion	fusion	NN
cord-001835-0s7ok4uw	5081	21	to	to	TO
cord-001835-0s7ok4uw	5081	22	occur	occur	VB
cord-001835-0s7ok4uw	5081	23	.	.	.
cord-001835-0s7ok4uw	5082	1	However	however	RB
cord-001835-0s7ok4uw	5082	2	,	,	,
cord-001835-0s7ok4uw	5082	3	the	the	DT
cord-001835-0s7ok4uw	5082	4	process	process	NN
cord-001835-0s7ok4uw	5082	5	of	of	IN
cord-001835-0s7ok4uw	5082	6	regulation	regulation	NN
cord-001835-0s7ok4uw	5082	7	of	of	IN
cord-001835-0s7ok4uw	5082	8	SNARE	snare	NN
cord-001835-0s7ok4uw	5082	9	-	-	HYPH
cord-001835-0s7ok4uw	5082	10	mediated	mediate	VBN
cord-001835-0s7ok4uw	5082	11	fusion	fusion	NN
cord-001835-0s7ok4uw	5082	12	remains	remain	VBZ
cord-001835-0s7ok4uw	5082	13	very	very	RB
cord-001835-0s7ok4uw	5082	14	poorly	poorly	RB
cord-001835-0s7ok4uw	5082	15	understood	understand	VBN
cord-001835-0s7ok4uw	5082	16	.	.	.
cord-001835-0s7ok4uw	5083	1	The	the	DT
cord-001835-0s7ok4uw	5083	2	major	major	JJ
cord-001835-0s7ok4uw	5083	3	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	5083	4	proteins	protein	NNS
cord-001835-0s7ok4uw	5083	5	involved	involve	VBN
cord-001835-0s7ok4uw	5083	6	in	in	IN
cord-001835-0s7ok4uw	5083	7	the	the	DT
cord-001835-0s7ok4uw	5083	8	process	process	NN
cord-001835-0s7ok4uw	5083	9	are	be	VBP
cord-001835-0s7ok4uw	5083	10	Munc	Munc	NNP
cord-001835-0s7ok4uw	5083	11	18	18	CD
cord-001835-0s7ok4uw	5083	12	,	,	,
cord-001835-0s7ok4uw	5083	13	Munc	Munc	NNP
cord-001835-0s7ok4uw	5083	14	13	13	CD
cord-001835-0s7ok4uw	5083	15	,	,	,
cord-001835-0s7ok4uw	5083	16	Synaptotagmin	Synaptotagmin	NNP
cord-001835-0s7ok4uw	5083	17	and	and	CC
cord-001835-0s7ok4uw	5083	18	Complexin	Complexin	NNP
cord-001835-0s7ok4uw	5083	19	.	.	.
cord-001835-0s7ok4uw	5084	1	The	the	DT
cord-001835-0s7ok4uw	5084	2	major	major	JJ
cord-001835-0s7ok4uw	5084	3	aim	aim	NN
cord-001835-0s7ok4uw	5084	4	of	of	IN
cord-001835-0s7ok4uw	5084	5	my	-PRON-	PRP$
cord-001835-0s7ok4uw	5084	6	project	project	NN
cord-001835-0s7ok4uw	5084	7	is	be	VBZ
cord-001835-0s7ok4uw	5084	8	to	to	TO
cord-001835-0s7ok4uw	5084	9	obtain	obtain	VB
cord-001835-0s7ok4uw	5084	10	a	a	DT
cord-001835-0s7ok4uw	5084	11	closer	close	JJR
cord-001835-0s7ok4uw	5084	12	look	look	NN
cord-001835-0s7ok4uw	5084	13	at	at	IN
cord-001835-0s7ok4uw	5084	14	the	the	DT
cord-001835-0s7ok4uw	5084	15	regulation	regulation	NN
cord-001835-0s7ok4uw	5084	16	process	process	NN
cord-001835-0s7ok4uw	5084	17	of	of	IN
cord-001835-0s7ok4uw	5084	18	SNARE	snare	NN
cord-001835-0s7ok4uw	5084	19	-	-	HYPH
cord-001835-0s7ok4uw	5084	20	mediated	mediate	VBN
cord-001835-0s7ok4uw	5084	21	fusion	fusion	NN
cord-001835-0s7ok4uw	5084	22	by	by	IN
cord-001835-0s7ok4uw	5084	23	focusing	focus	VBG
cord-001835-0s7ok4uw	5084	24	on	on	IN
cord-001835-0s7ok4uw	5084	25	the	the	DT
cord-001835-0s7ok4uw	5084	26	interaction	interaction	NN
cord-001835-0s7ok4uw	5084	27	between	between	IN
cord-001835-0s7ok4uw	5084	28	the	the	DT
cord-001835-0s7ok4uw	5084	29	SNARE	snare	NN
cord-001835-0s7ok4uw	5084	30	proteins	protein	NNS
cord-001835-0s7ok4uw	5084	31	and	and	CC
cord-001835-0s7ok4uw	5084	32	the	the	DT
cord-001835-0s7ok4uw	5084	33	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	5084	34	proteins	protein	NNS
cord-001835-0s7ok4uw	5084	35	.	.	.
cord-001835-0s7ok4uw	5085	1	To	to	TO
cord-001835-0s7ok4uw	5085	2	achieve	achieve	VB
cord-001835-0s7ok4uw	5085	3	this	this	DT
cord-001835-0s7ok4uw	5085	4	objective	objective	NN
cord-001835-0s7ok4uw	5085	5	,	,	,
cord-001835-0s7ok4uw	5085	6	I	-PRON-	PRP
cord-001835-0s7ok4uw	5085	7	express	express	VBP
cord-001835-0s7ok4uw	5085	8	and	and	CC
cord-001835-0s7ok4uw	5085	9	purify	purify	VB
cord-001835-0s7ok4uw	5085	10	the	the	DT
cord-001835-0s7ok4uw	5085	11	different	different	JJ
cord-001835-0s7ok4uw	5085	12	proteins	protein	NNS
cord-001835-0s7ok4uw	5085	13	involved	involve	VBN
cord-001835-0s7ok4uw	5085	14	in	in	IN
cord-001835-0s7ok4uw	5085	15	the	the	DT
cord-001835-0s7ok4uw	5085	16	process	process	NN
cord-001835-0s7ok4uw	5085	17	of	of	IN
cord-001835-0s7ok4uw	5085	18	SNARE	snare	NN
cord-001835-0s7ok4uw	5085	19	-	-	HYPH
cord-001835-0s7ok4uw	5085	20	mediated	mediate	VBN
cord-001835-0s7ok4uw	5085	21	fusion	fusion	NN
cord-001835-0s7ok4uw	5085	22	and	and	CC
cord-001835-0s7ok4uw	5085	23	thereafter	thereafter	RB
cord-001835-0s7ok4uw	5085	24	subject	subject	VB
cord-001835-0s7ok4uw	5085	25	them	-PRON-	PRP
cord-001835-0s7ok4uw	5085	26	to	to	TO
cord-001835-0s7ok4uw	5085	27	appropriate	appropriate	VB
cord-001835-0s7ok4uw	5085	28	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5085	29	characterization	characterization	NN
cord-001835-0s7ok4uw	5085	30	.	.	.
cord-001835-0s7ok4uw	5086	1	In	in	IN
cord-001835-0s7ok4uw	5086	2	order	order	NN
cord-001835-0s7ok4uw	5086	3	to	to	TO
cord-001835-0s7ok4uw	5086	4	assess	assess	VB
cord-001835-0s7ok4uw	5086	5	the	the	DT
cord-001835-0s7ok4uw	5086	6	role	role	NN
cord-001835-0s7ok4uw	5086	7	of	of	IN
cord-001835-0s7ok4uw	5086	8	the	the	DT
cord-001835-0s7ok4uw	5086	9	purified	purify	VBN
cord-001835-0s7ok4uw	5086	10	proteins	protein	NNS
cord-001835-0s7ok4uw	5086	11	in	in	IN
cord-001835-0s7ok4uw	5086	12	the	the	DT
cord-001835-0s7ok4uw	5086	13	process	process	NN
cord-001835-0s7ok4uw	5086	14	of	of	IN
cord-001835-0s7ok4uw	5086	15	fusion	fusion	NN
cord-001835-0s7ok4uw	5086	16	,	,	,
cord-001835-0s7ok4uw	5086	17	I	-PRON-	PRP
cord-001835-0s7ok4uw	5086	18	reconstitute	reconstitute	VBP
cord-001835-0s7ok4uw	5086	19	them	-PRON-	PRP
cord-001835-0s7ok4uw	5086	20	into	into	IN
cord-001835-0s7ok4uw	5086	21	liposomes	liposome	NNS
cord-001835-0s7ok4uw	5086	22	and	and	CC
cord-001835-0s7ok4uw	5086	23	perform	perform	VB
cord-001835-0s7ok4uw	5086	24	in	in	IN
cord-001835-0s7ok4uw	5086	25	-	-	HYPH
cord-001835-0s7ok4uw	5086	26	vitro	vitro	FW
cord-001835-0s7ok4uw	5086	27	lipidmixing	lipidmixing	NN
cord-001835-0s7ok4uw	5086	28	assays	assay	NNS
cord-001835-0s7ok4uw	5086	29	.	.	.
cord-001835-0s7ok4uw	5087	1	These	these	DT
cord-001835-0s7ok4uw	5087	2	assays	assay	NNS
cord-001835-0s7ok4uw	5087	3	are	be	VBP
cord-001835-0s7ok4uw	5087	4	based	base	VBN
cord-001835-0s7ok4uw	5087	5	on	on	IN
cord-001835-0s7ok4uw	5087	6	F	F	NNP
cord-001835-0s7ok4uw	5087	7	orster	orster	NN
cord-001835-0s7ok4uw	5087	8	Resonance	Resonance	NNP
cord-001835-0s7ok4uw	5087	9	Energy	Energy	NNP
cord-001835-0s7ok4uw	5087	10	Transfer	Transfer	NNP
cord-001835-0s7ok4uw	5087	11	(	(	-LRB-
cord-001835-0s7ok4uw	5087	12	FRET	FRET	NNP
cord-001835-0s7ok4uw	5087	13	)	)	-RRB-
cord-001835-0s7ok4uw	5087	14	.	.	.
cord-001835-0s7ok4uw	5088	1	Based	base	VBN
cord-001835-0s7ok4uw	5088	2	on	on	IN
cord-001835-0s7ok4uw	5088	3	the	the	DT
cord-001835-0s7ok4uw	5088	4	discretion	discretion	NN
cord-001835-0s7ok4uw	5088	5	of	of	IN
cord-001835-0s7ok4uw	5088	6	assessing	assess	VBG
cord-001835-0s7ok4uw	5088	7	the	the	DT
cord-001835-0s7ok4uw	5088	8	protein	protein	NN
cord-001835-0s7ok4uw	5088	9	-	-	HYPH
cord-001835-0s7ok4uw	5088	10	protein	protein	NN
cord-001835-0s7ok4uw	5088	11	or	or	CC
cord-001835-0s7ok4uw	5088	12	protein	protein	NN
cord-001835-0s7ok4uw	5088	13	-	-	HYPH
cord-001835-0s7ok4uw	5088	14	lipid	lipid	NN
cord-001835-0s7ok4uw	5088	15	interactions	interaction	NNS
cord-001835-0s7ok4uw	5088	16	,	,	,
cord-001835-0s7ok4uw	5088	17	either	either	CC
cord-001835-0s7ok4uw	5088	18	the	the	DT
cord-001835-0s7ok4uw	5088	19	proteins	protein	NNS
cord-001835-0s7ok4uw	5088	20	or	or	CC
cord-001835-0s7ok4uw	5088	21	the	the	DT
cord-001835-0s7ok4uw	5088	22	lipids	lipid	NNS
cord-001835-0s7ok4uw	5088	23	can	can	MD
cord-001835-0s7ok4uw	5088	24	be	be	VB
cord-001835-0s7ok4uw	5088	25	fluorescently	fluorescently	RB
cord-001835-0s7ok4uw	5088	26	labeled	label	VBN
cord-001835-0s7ok4uw	5088	27	.	.	.
cord-001835-0s7ok4uw	5089	1	Also	also	RB
cord-001835-0s7ok4uw	5089	2	,	,	,
cord-001835-0s7ok4uw	5089	3	the	the	DT
cord-001835-0s7ok4uw	5089	4	lipid	lipid	NN
cord-001835-0s7ok4uw	5089	5	compositions	composition	NNS
cord-001835-0s7ok4uw	5089	6	can	can	MD
cord-001835-0s7ok4uw	5089	7	be	be	VB
cord-001835-0s7ok4uw	5089	8	varied	varied	JJ
cord-001835-0s7ok4uw	5089	9	in	in	IN
cord-001835-0s7ok4uw	5089	10	order	order	NN
cord-001835-0s7ok4uw	5089	11	to	to	TO
cord-001835-0s7ok4uw	5089	12	assess	assess	VB
cord-001835-0s7ok4uw	5089	13	the	the	DT
cord-001835-0s7ok4uw	5089	14	effect	effect	NN
cord-001835-0s7ok4uw	5089	15	of	of	IN
cord-001835-0s7ok4uw	5089	16	lipid	lipid	NN
cord-001835-0s7ok4uw	5089	17	on	on	IN
cord-001835-0s7ok4uw	5089	18	the	the	DT
cord-001835-0s7ok4uw	5089	19	function	function	NN
cord-001835-0s7ok4uw	5089	20	of	of	IN
cord-001835-0s7ok4uw	5089	21	the	the	DT
cord-001835-0s7ok4uw	5089	22	respective	respective	JJ
cord-001835-0s7ok4uw	5089	23	protein	protein	NN
cord-001835-0s7ok4uw	5089	24	.	.	.
cord-001835-0s7ok4uw	5090	1	Fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	5090	2	-	-	HYPH
cord-001835-0s7ok4uw	5090	3	based	base	VBN
cord-001835-0s7ok4uw	5090	4	anisotropy	anisotropy	NN
cord-001835-0s7ok4uw	5090	5	measurements	measurement	NNS
cord-001835-0s7ok4uw	5090	6	can	can	MD
cord-001835-0s7ok4uw	5090	7	also	also	RB
cord-001835-0s7ok4uw	5090	8	provide	provide	VB
cord-001835-0s7ok4uw	5090	9	information	information	NN
cord-001835-0s7ok4uw	5090	10	about	about	IN
cord-001835-0s7ok4uw	5090	11	the	the	DT
cord-001835-0s7ok4uw	5090	12	degree	degree	NN
cord-001835-0s7ok4uw	5090	13	of	of	IN
cord-001835-0s7ok4uw	5090	14	freedom	freedom	NN
cord-001835-0s7ok4uw	5090	15	of	of	IN
cord-001835-0s7ok4uw	5090	16	a	a	DT
cord-001835-0s7ok4uw	5090	17	protein	protein	NN
cord-001835-0s7ok4uw	5090	18	,	,	,
cord-001835-0s7ok4uw	5090	19	indirectly	indirectly	RB
cord-001835-0s7ok4uw	5090	20	providing	provide	VBG
cord-001835-0s7ok4uw	5090	21	information	information	NN
cord-001835-0s7ok4uw	5090	22	about	about	IN
cord-001835-0s7ok4uw	5090	23	the	the	DT
cord-001835-0s7ok4uw	5090	24	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	5090	25	of	of	IN
cord-001835-0s7ok4uw	5090	26	a	a	DT
cord-001835-0s7ok4uw	5090	27	reaction	reaction	NN
cord-001835-0s7ok4uw	5090	28	.	.	.
cord-001835-0s7ok4uw	5091	1	Employing	employ	VBG
cord-001835-0s7ok4uw	5091	2	these	these	DT
cord-001835-0s7ok4uw	5091	3	techniques	technique	NNS
cord-001835-0s7ok4uw	5091	4	,	,	,
cord-001835-0s7ok4uw	5091	5	I	-PRON-	PRP
cord-001835-0s7ok4uw	5091	6	observe	observe	VBP
cord-001835-0s7ok4uw	5091	7	that	that	IN
cord-001835-0s7ok4uw	5091	8	Munc	Munc	NNP
cord-001835-0s7ok4uw	5091	9	18	18	CD
cord-001835-0s7ok4uw	5091	10	-	-	SYM
cord-001835-0s7ok4uw	5091	11	1	1	CD
cord-001835-0s7ok4uw	5091	12	leads	lead	NNS
cord-001835-0s7ok4uw	5091	13	to	to	IN
cord-001835-0s7ok4uw	5091	14	displacement	displacement	NN
cord-001835-0s7ok4uw	5091	15	of	of	IN
cord-001835-0s7ok4uw	5091	16	Syntaxin	Syntaxin	NNP
cord-001835-0s7ok4uw	5091	17	from	from	IN
cord-001835-0s7ok4uw	5091	18	a	a	DT
cord-001835-0s7ok4uw	5091	19	complex	complex	NN
cord-001835-0s7ok4uw	5091	20	of	of	IN
cord-001835-0s7ok4uw	5091	21	Syntaxin	Syntaxin	NNP
cord-001835-0s7ok4uw	5091	22	and	and	CC
cord-001835-0s7ok4uw	5091	23	SNAP25	SNAP25	NNP
cord-001835-0s7ok4uw	5091	24	.	.	.
cord-001835-0s7ok4uw	5092	1	Also	also	RB
cord-001835-0s7ok4uw	5092	2	,	,	,
cord-001835-0s7ok4uw	5092	3	a	a	DT
cord-001835-0s7ok4uw	5092	4	complex	complex	NN
cord-001835-0s7ok4uw	5092	5	of	of	IN
cord-001835-0s7ok4uw	5092	6	Syntaxin	Syntaxin	NNP
cord-001835-0s7ok4uw	5092	7	and	and	CC
cord-001835-0s7ok4uw	5092	8	Munc	Munc	NNP
cord-001835-0s7ok4uw	5092	9	18	18	CD
cord-001835-0s7ok4uw	5092	10	is	be	VBZ
cord-001835-0s7ok4uw	5092	11	resistant	resistant	JJ
cord-001835-0s7ok4uw	5092	12	to	to	IN
cord-001835-0s7ok4uw	5092	13	the	the	DT
cord-001835-0s7ok4uw	5092	14	action	action	NN
cord-001835-0s7ok4uw	5092	15	of	of	IN
cord-001835-0s7ok4uw	5092	16	the	the	DT
cord-001835-0s7ok4uw	5092	17	AAA	AAA	NNP
cord-001835-0s7ok4uw	5092	18	-	-	HYPH
cord-001835-0s7ok4uw	5092	19	ATPase	ATPase	NNP
cord-001835-0s7ok4uw	5092	20	,	,	,
cord-001835-0s7ok4uw	5092	21	NSF	NSF	NNP
cord-001835-0s7ok4uw	5092	22	and	and	CC
cord-001835-0s7ok4uw	5092	23	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5092	24	co	co	NN
cord-001835-0s7ok4uw	5092	25	-	-	NN
cord-001835-0s7ok4uw	5092	26	factor	factor	NN
cord-001835-0s7ok4uw	5092	27	aSNAP	asnap	NN
cord-001835-0s7ok4uw	5092	28	,	,	,
cord-001835-0s7ok4uw	5092	29	implicating	implicate	VBG
cord-001835-0s7ok4uw	5092	30	this	this	DT
cord-001835-0s7ok4uw	5092	31	complex	complex	NN
cord-001835-0s7ok4uw	5092	32	as	as	IN
cord-001835-0s7ok4uw	5092	33	a	a	DT
cord-001835-0s7ok4uw	5092	34	strong	strong	JJ
cord-001835-0s7ok4uw	5092	35	candidate	candidate	NN
cord-001835-0s7ok4uw	5092	36	for	for	IN
cord-001835-0s7ok4uw	5092	37	acting	act	VBG
cord-001835-0s7ok4uw	5092	38	as	as	IN
cord-001835-0s7ok4uw	5092	39	the	the	DT
cord-001835-0s7ok4uw	5092	40	starting	starting	NN
cord-001835-0s7ok4uw	5092	41	point	point	NN
cord-001835-0s7ok4uw	5092	42	for	for	IN
cord-001835-0s7ok4uw	5092	43	the	the	DT
cord-001835-0s7ok4uw	5092	44	process	process	NN
cord-001835-0s7ok4uw	5092	45	of	of	IN
cord-001835-0s7ok4uw	5092	46	neurotransmitter	neurotransmitter	NN
cord-001835-0s7ok4uw	5092	47	release	release	NN
cord-001835-0s7ok4uw	5092	48	.	.	.
cord-001835-0s7ok4uw	5093	1	Munc	Munc	NNP
cord-001835-0s7ok4uw	5093	2	18	18	CD
cord-001835-0s7ok4uw	5093	3	also	also	RB
cord-001835-0s7ok4uw	5093	4	appears	appear	VBZ
cord-001835-0s7ok4uw	5093	5	to	to	TO
cord-001835-0s7ok4uw	5093	6	enhance	enhance	VB
cord-001835-0s7ok4uw	5093	7	lipid	lipid	NN
cord-001835-0s7ok4uw	5093	8	-	-	HYPH
cord-001835-0s7ok4uw	5093	9	mixing	mixing	NN
cord-001835-0s7ok4uw	5093	10	by	by	IN
cord-001835-0s7ok4uw	5093	11	interacting	interact	VBG
cord-001835-0s7ok4uw	5093	12	with	with	IN
cord-001835-0s7ok4uw	5093	13	the	the	DT
cord-001835-0s7ok4uw	5093	14	SNARE	snare	NN
cord-001835-0s7ok4uw	5093	15	-	-	HYPH
cord-001835-0s7ok4uw	5093	16	complex	complex	NN
cord-001835-0s7ok4uw	5093	17	.	.	.
cord-001835-0s7ok4uw	5094	1	Further	further	JJ
cord-001835-0s7ok4uw	5094	2	investigations	investigation	NNS
cord-001835-0s7ok4uw	5094	3	on	on	IN
cord-001835-0s7ok4uw	5094	4	the	the	DT
cord-001835-0s7ok4uw	5094	5	same	same	JJ
cord-001835-0s7ok4uw	5094	6	lines	line	NNS
cord-001835-0s7ok4uw	5094	7	can	can	MD
cord-001835-0s7ok4uw	5094	8	provide	provide	VB
cord-001835-0s7ok4uw	5094	9	very	very	RB
cord-001835-0s7ok4uw	5094	10	useful	useful	JJ
cord-001835-0s7ok4uw	5094	11	insights	insight	NNS
cord-001835-0s7ok4uw	5094	12	into	into	IN
cord-001835-0s7ok4uw	5094	13	the	the	DT
cord-001835-0s7ok4uw	5094	14	process	process	NN
cord-001835-0s7ok4uw	5094	15	and	and	CC
cord-001835-0s7ok4uw	5094	16	can	can	MD
cord-001835-0s7ok4uw	5094	17	help	help	VB
cord-001835-0s7ok4uw	5094	18	us	-PRON-	PRP
cord-001835-0s7ok4uw	5094	19	unravel	unravel	VB
cord-001835-0s7ok4uw	5094	20	the	the	DT
cord-001835-0s7ok4uw	5094	21	secrets	secret	NNS
cord-001835-0s7ok4uw	5094	22	that	that	WDT
cord-001835-0s7ok4uw	5094	23	underlie	underlie	VBP
cord-001835-0s7ok4uw	5094	24	the	the	DT
cord-001835-0s7ok4uw	5094	25	beauty	beauty	NN
cord-001835-0s7ok4uw	5094	26	of	of	IN
cord-001835-0s7ok4uw	5094	27	the	the	DT
cord-001835-0s7ok4uw	5094	28	exquisitely	exquisitely	RB
cord-001835-0s7ok4uw	5094	29	regulated	regulate	VBN
cord-001835-0s7ok4uw	5094	30	process	process	NN
cord-001835-0s7ok4uw	5094	31	of	of	IN
cord-001835-0s7ok4uw	5094	32	neurotransmitter	neurotransmitter	NN
cord-001835-0s7ok4uw	5094	33	release	release	NN
cord-001835-0s7ok4uw	5094	34	.	.	.
cord-001835-0s7ok4uw	5095	1	Binding	bind	VBG
cord-001835-0s7ok4uw	5095	2	of	of	IN
cord-001835-0s7ok4uw	5095	3	thymidine	thymidine	NN
cord-001835-0s7ok4uw	5095	4	nucleotides	nucleotide	NNS
cord-001835-0s7ok4uw	5095	5	to	to	IN
cord-001835-0s7ok4uw	5095	6	a	a	DT
cord-001835-0s7ok4uw	5095	7	viral	viral	JJ
cord-001835-0s7ok4uw	5095	8	thymidine	thymidine	NN
cord-001835-0s7ok4uw	5095	9	monophosphate	monophosphate	NN
cord-001835-0s7ok4uw	5095	10	kinase	kinase	VBZ
cord-001835-0s7ok4uw	5095	11	Aldo	Aldo	NNP
cord-001835-0s7ok4uw	5095	12	A.	a.	NN
cord-001835-0s7ok4uw	5095	13	3	3	CD
cord-001835-0s7ok4uw	5095	14	Centro	Centro	NNP
cord-001835-0s7ok4uw	5095	15	de	de	NNP
cord-001835-0s7ok4uw	5095	16	Investigaci	Investigaci	NNP
cord-001835-0s7ok4uw	5095	17	on	on	IN
cord-001835-0s7ok4uw	5095	18	en	en	NNP
cord-001835-0s7ok4uw	5095	19	Alimentaci	Alimentaci	NNP
cord-001835-0s7ok4uw	5095	20	on	on	IN
cord-001835-0s7ok4uw	5095	21	y	y	NNP
cord-001835-0s7ok4uw	5095	22	Desarrollo	Desarrollo	NNP
cord-001835-0s7ok4uw	5095	23	THEME	theme	NN
cord-001835-0s7ok4uw	5095	24	:	:	:
cord-001835-0s7ok4uw	5096	1	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	5096	2	There	there	EX
cord-001835-0s7ok4uw	5096	3	is	be	VBZ
cord-001835-0s7ok4uw	5096	4	great	great	JJ
cord-001835-0s7ok4uw	5096	5	interest	interest	NN
cord-001835-0s7ok4uw	5096	6	in	in	IN
cord-001835-0s7ok4uw	5096	7	the	the	DT
cord-001835-0s7ok4uw	5096	8	evolution	evolution	NN
cord-001835-0s7ok4uw	5096	9	and	and	CC
cord-001835-0s7ok4uw	5096	10	activities	activity	NNS
cord-001835-0s7ok4uw	5096	11	of	of	IN
cord-001835-0s7ok4uw	5096	12	fish	fish	NN
cord-001835-0s7ok4uw	5096	13	trypsins	trypsin	NNS
cord-001835-0s7ok4uw	5096	14	,	,	,
cord-001835-0s7ok4uw	5096	15	since	since	IN
cord-001835-0s7ok4uw	5096	16	they	-PRON-	PRP
cord-001835-0s7ok4uw	5096	17	appear	appear	VBP
cord-001835-0s7ok4uw	5096	18	to	to	TO
cord-001835-0s7ok4uw	5096	19	have	have	VB
cord-001835-0s7ok4uw	5096	20	evolved	evolve	VBN
cord-001835-0s7ok4uw	5096	21	into	into	IN
cord-001835-0s7ok4uw	5096	22	different	different	JJ
cord-001835-0s7ok4uw	5096	23	families	family	NNS
cord-001835-0s7ok4uw	5096	24	.	.	.
cord-001835-0s7ok4uw	5097	1	The	the	DT
cord-001835-0s7ok4uw	5097	2	cDNA	cdna	NN
cord-001835-0s7ok4uw	5097	3	for	for	IN
cord-001835-0s7ok4uw	5097	4	trypsin	trypsin	NN
cord-001835-0s7ok4uw	5097	5	III	III	NNP
cord-001835-0s7ok4uw	5097	6	from	from	IN
cord-001835-0s7ok4uw	5097	7	the	the	DT
cord-001835-0s7ok4uw	5097	8	Monterey	Monterey	NNP
cord-001835-0s7ok4uw	5097	9	sardine	sardine	NN
cord-001835-0s7ok4uw	5097	10	(	(	-LRB-
cord-001835-0s7ok4uw	5097	11	Sardinops	Sardinops	NNP
cord-001835-0s7ok4uw	5097	12	sagax	sagax	NN
cord-001835-0s7ok4uw	5097	13	caerula	caerula	NNP
cord-001835-0s7ok4uw	5097	14	)	)	-RRB-
cord-001835-0s7ok4uw	5097	15	was	be	VBD
cord-001835-0s7ok4uw	5097	16	obtained	obtain	VBN
cord-001835-0s7ok4uw	5097	17	and	and	CC
cord-001835-0s7ok4uw	5097	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5097	19	deduced	deduce	VBN
cord-001835-0s7ok4uw	5097	20	amino	amino	NN
cord-001835-0s7ok4uw	5097	21	acid	acid	NN
cord-001835-0s7ok4uw	5097	22	sequence	sequence	NN
cord-001835-0s7ok4uw	5097	23	matched	match	VBD
cord-001835-0s7ok4uw	5097	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5097	25	identity	identity	NN
cord-001835-0s7ok4uw	5097	26	with	with	IN
cord-001835-0s7ok4uw	5097	27	a	a	DT
cord-001835-0s7ok4uw	5097	28	purified	purify	VBN
cord-001835-0s7ok4uw	5097	29	protease	protease	NN
cord-001835-0s7ok4uw	5097	30	from	from	IN
cord-001835-0s7ok4uw	5097	31	the	the	DT
cord-001835-0s7ok4uw	5097	32	fish	fish	NN
cord-001835-0s7ok4uw	5097	33	by	by	IN
cord-001835-0s7ok4uw	5097	34	mass	mass	NN
cord-001835-0s7ok4uw	5097	35	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	5097	36	analysis	analysis	NN
cord-001835-0s7ok4uw	5097	37	.	.	.
cord-001835-0s7ok4uw	5098	1	Molecular	molecular	JJ
cord-001835-0s7ok4uw	5098	2	modeling	modeling	NN
cord-001835-0s7ok4uw	5098	3	of	of	IN
cord-001835-0s7ok4uw	5098	4	sardine	sardine	NN
cord-001835-0s7ok4uw	5098	5	trypsin	trypsin	NN
cord-001835-0s7ok4uw	5098	6	III	III	NNP
cord-001835-0s7ok4uw	5098	7	compared	compare	VBN
cord-001835-0s7ok4uw	5098	8	to	to	IN
cord-001835-0s7ok4uw	5098	9	other	other	JJ
cord-001835-0s7ok4uw	5098	10	homologs	homolog	NNS
cord-001835-0s7ok4uw	5098	11	showed	show	VBD
cord-001835-0s7ok4uw	5098	12	a	a	DT
cord-001835-0s7ok4uw	5098	13	typical	typical	JJ
cord-001835-0s7ok4uw	5098	14	trypsin	trypsin	NN
cord-001835-0s7ok4uw	5098	15	fold	fold	VBG
cord-001835-0s7ok4uw	5098	16	with	with	IN
cord-001835-0s7ok4uw	5098	17	all	all	PDT
cord-001835-0s7ok4uw	5098	18	the	the	DT
cord-001835-0s7ok4uw	5098	19	cognate	cognate	JJ
cord-001835-0s7ok4uw	5098	20	components	component	NNS
cord-001835-0s7ok4uw	5098	21	for	for	IN
cord-001835-0s7ok4uw	5098	22	catalysis	catalysis	NN
cord-001835-0s7ok4uw	5098	23	,	,	,
cord-001835-0s7ok4uw	5098	24	and	and	CC
cord-001835-0s7ok4uw	5098	25	specific	specific	JJ
cord-001835-0s7ok4uw	5098	26	amino	amino	NN
cord-001835-0s7ok4uw	5098	27	acid	acid	NN
cord-001835-0s7ok4uw	5098	28	distribution	distribution	NN
cord-001835-0s7ok4uw	5098	29	that	that	WDT
cord-001835-0s7ok4uw	5098	30	are	be	VBP
cord-001835-0s7ok4uw	5098	31	possible	possible	JJ
cord-001835-0s7ok4uw	5098	32	factors	factor	NNS
cord-001835-0s7ok4uw	5098	33	that	that	WDT
cord-001835-0s7ok4uw	5098	34	explain	explain	VBP
cord-001835-0s7ok4uw	5098	35	the	the	DT
cord-001835-0s7ok4uw	5098	36	cold	cold	JJ
cord-001835-0s7ok4uw	5098	37	adaptation	adaptation	NN
cord-001835-0s7ok4uw	5098	38	.	.	.
cord-001835-0s7ok4uw	5099	1	From	from	IN
cord-001835-0s7ok4uw	5099	2	phylogenetic	phylogenetic	JJ
cord-001835-0s7ok4uw	5099	3	analysis	analysis	NN
cord-001835-0s7ok4uw	5099	4	,	,	,
cord-001835-0s7ok4uw	5099	5	sardine	sardine	NN
cord-001835-0s7ok4uw	5099	6	trypsin	trypsin	NN
cord-001835-0s7ok4uw	5099	7	III	III	NNP
cord-001835-0s7ok4uw	5099	8	belongs	belong	VBZ
cord-001835-0s7ok4uw	5099	9	to	to	IN
cord-001835-0s7ok4uw	5099	10	the	the	DT
cord-001835-0s7ok4uw	5099	11	novel	novel	NN
cord-001835-0s7ok4uw	5099	12	Y	Y	NNP
cord-001835-0s7ok4uw	5099	13	family	family	NN
cord-001835-0s7ok4uw	5099	14	,	,	,
cord-001835-0s7ok4uw	5099	15	which	which	WDT
cord-001835-0s7ok4uw	5099	16	is	be	VBZ
cord-001835-0s7ok4uw	5099	17	proposed	propose	VBN
cord-001835-0s7ok4uw	5099	18	to	to	TO
cord-001835-0s7ok4uw	5099	19	have	have	VB
cord-001835-0s7ok4uw	5099	20	evolved	evolve	VBN
cord-001835-0s7ok4uw	5099	21	for	for	IN
cord-001835-0s7ok4uw	5099	22	cold	cold	JJ
cord-001835-0s7ok4uw	5099	23	adaptation	adaptation	NN
cord-001835-0s7ok4uw	5099	24	.	.	.
cord-001835-0s7ok4uw	5100	1	The	the	DT
cord-001835-0s7ok4uw	5100	2	obtained	obtain	VBN
cord-001835-0s7ok4uw	5100	3	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	5100	4	trypsin	trypsin	NN
cord-001835-0s7ok4uw	5100	5	III	III	NNP
cord-001835-0s7ok4uw	5100	6	showed	show	VBD
cord-001835-0s7ok4uw	5100	7	a	a	DT
cord-001835-0s7ok4uw	5100	8	low	low	JJ
cord-001835-0s7ok4uw	5100	9	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5100	10	efficiency	efficiency	NN
cord-001835-0s7ok4uw	5100	11	,	,	,
cord-001835-0s7ok4uw	5100	12	but	but	CC
cord-001835-0s7ok4uw	5100	13	it	-PRON-	PRP
cord-001835-0s7ok4uw	5100	14	remained	remain	VBD
cord-001835-0s7ok4uw	5100	15	active	active	JJ
cord-001835-0s7ok4uw	5100	16	at	at	IN
cord-001835-0s7ok4uw	5100	17	cold	cold	JJ
cord-001835-0s7ok4uw	5100	18	temperatures	temperature	NNS
cord-001835-0s7ok4uw	5100	19	,	,	,
cord-001835-0s7ok4uw	5100	20	similar	similar	JJ
cord-001835-0s7ok4uw	5100	21	to	to	IN
cord-001835-0s7ok4uw	5100	22	other	other	JJ
cord-001835-0s7ok4uw	5100	23	cold	cold	NN
cord-001835-0s7ok4uw	5100	24	-	-	HYPH
cord-001835-0s7ok4uw	5100	25	adapted	adapt	VBN
cord-001835-0s7ok4uw	5100	26	trypsins	trypsin	NNS
cord-001835-0s7ok4uw	5100	27	.	.	.
cord-001835-0s7ok4uw	5101	1	The	the	DT
cord-001835-0s7ok4uw	5101	2	cold	cold	JJ
cord-001835-0s7ok4uw	5101	3	-	-	HYPH
cord-001835-0s7ok4uw	5101	4	adaptation	adaptation	NN
cord-001835-0s7ok4uw	5101	5	of	of	IN
cord-001835-0s7ok4uw	5101	6	sardine	sardine	NN
cord-001835-0s7ok4uw	5101	7	trypsin	trypsin	NN
cord-001835-0s7ok4uw	5101	8	III	III	NNP
cord-001835-0s7ok4uw	5101	9	opens	open	VBZ
cord-001835-0s7ok4uw	5101	10	a	a	DT
cord-001835-0s7ok4uw	5101	11	wide	wide	JJ
cord-001835-0s7ok4uw	5101	12	range	range	NN
cord-001835-0s7ok4uw	5101	13	of	of	IN
cord-001835-0s7ok4uw	5101	14	biotechnological	biotechnological	JJ
cord-001835-0s7ok4uw	5101	15	applications	application	NNS
cord-001835-0s7ok4uw	5101	16	for	for	IN
cord-001835-0s7ok4uw	5101	17	this	this	DT
cord-001835-0s7ok4uw	5101	18	protease	protease	NN
cord-001835-0s7ok4uw	5101	19	and	and	CC
cord-001835-0s7ok4uw	5101	20	is	be	VBZ
cord-001835-0s7ok4uw	5101	21	also	also	RB
cord-001835-0s7ok4uw	5101	22	interesting	interesting	JJ
cord-001835-0s7ok4uw	5101	23	from	from	IN
cord-001835-0s7ok4uw	5101	24	the	the	DT
cord-001835-0s7ok4uw	5101	25	serine	serine	JJ
cord-001835-0s7ok4uw	5101	26	protease	protease	NN
cord-001835-0s7ok4uw	5101	27	structure	structure	NN
cord-001835-0s7ok4uw	5101	28	-	-	HYPH
cord-001835-0s7ok4uw	5101	29	function	function	NN
cord-001835-0s7ok4uw	5101	30	relationship	relationship	NN
cord-001835-0s7ok4uw	5101	31	point	point	NN
cord-001835-0s7ok4uw	5101	32	of	of	IN
cord-001835-0s7ok4uw	5101	33	view	view	NN
cord-001835-0s7ok4uw	5101	34	.	.	.
cord-001835-0s7ok4uw	5102	1	Fungicidal	fungicidal	JJ
cord-001835-0s7ok4uw	5102	2	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5102	3	of	of	IN
cord-001835-0s7ok4uw	5102	4	scolopendin	scolopendin	NNS
cord-001835-0s7ok4uw	5102	5	2	2	CD
cord-001835-0s7ok4uw	5102	6	,	,	,
cord-001835-0s7ok4uw	5102	7	a	a	DT
cord-001835-0s7ok4uw	5102	8	cationic	cationic	JJ
cord-001835-0s7ok4uw	5102	9	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5102	10	peptide	peptide	NN
cord-001835-0s7ok4uw	5102	11	from	from	IN
cord-001835-0s7ok4uw	5102	12	centipede	centipede	NN
cord-001835-0s7ok4uw	5102	13	Heejeong	Heejeong	NNP
cord-001835-0s7ok4uw	5102	14	Lee	Lee	NNP
cord-001835-0s7ok4uw	5102	15	1	1	CD
cord-001835-0s7ok4uw	5102	16	,	,	,
cord-001835-0s7ok4uw	5102	17	Dong	Dong	NNP
cord-001835-0s7ok4uw	5102	18	Gun	Gun	NNP
cord-001835-0s7ok4uw	5102	19	Lee	Lee	NNP
cord-001835-0s7ok4uw	5102	20	1	1	CD
cord-001835-0s7ok4uw	5102	21	drastically	drastically	RB
cord-001835-0s7ok4uw	5102	22	(	(	-LRB-
cord-001835-0s7ok4uw	5102	23	from	from	IN
cord-001835-0s7ok4uw	5102	24	6.5	6.5	CD
cord-001835-0s7ok4uw	5102	25	x	x	SYM
cord-001835-0s7ok4uw	5102	26	10	10	CD
cord-001835-0s7ok4uw	5102	27	-	-	SYM
cord-001835-0s7ok4uw	5102	28	3	3	CD
cord-001835-0s7ok4uw	5102	29	to	to	TO
cord-001835-0s7ok4uw	5102	30	2	2	CD
cord-001835-0s7ok4uw	5102	31	x	x	SYM
cord-001835-0s7ok4uw	5102	32	10	10	CD
cord-001835-0s7ok4uw	5102	33	-	-	SYM
cord-001835-0s7ok4uw	5102	34	3	3	CD
cord-001835-0s7ok4uw	5102	35	colonies	colony	NNS
cord-001835-0s7ok4uw	5102	36	)	)	-RRB-
cord-001835-0s7ok4uw	5102	37	upon	upon	IN
cord-001835-0s7ok4uw	5102	38	deletion	deletion	NN
cord-001835-0s7ok4uw	5102	39	of	of	IN
cord-001835-0s7ok4uw	5102	40	this	this	DT
cord-001835-0s7ok4uw	5102	41	130	130	CD
cord-001835-0s7ok4uw	5102	42	residues	residue	NNS
cord-001835-0s7ok4uw	5102	43	domain	domain	NN
cord-001835-0s7ok4uw	5102	44	from	from	IN
cord-001835-0s7ok4uw	5102	45	the	the	DT
cord-001835-0s7ok4uw	5102	46	full	full	JJ
cord-001835-0s7ok4uw	5102	47	length	length	NN
cord-001835-0s7ok4uw	5103	1	TraI.	trai.	CC
cord-001835-0s7ok4uw	5104	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5104	2	are	be	VBP
cord-001835-0s7ok4uw	5104	3	investigating	investigate	VBG
cord-001835-0s7ok4uw	5104	4	the	the	DT
cord-001835-0s7ok4uw	5104	5	structure	structure	NN
cord-001835-0s7ok4uw	5104	6	and	and	CC
cord-001835-0s7ok4uw	5104	7	function	function	NN
cord-001835-0s7ok4uw	5104	8	of	of	IN
cord-001835-0s7ok4uw	5104	9	this	this	DT
cord-001835-0s7ok4uw	5104	10	very	very	JJ
cord-001835-0s7ok4uw	5104	11	C	c	NN
cord-001835-0s7ok4uw	5104	12	-	-	HYPH
cord-001835-0s7ok4uw	5104	13	terminal	terminal	NN
cord-001835-0s7ok4uw	5104	14	end	end	NN
cord-001835-0s7ok4uw	5104	15	of	of	IN
cord-001835-0s7ok4uw	5104	16	TraI	TraI	NNP
cord-001835-0s7ok4uw	5104	17	using	use	VBG
cord-001835-0s7ok4uw	5104	18	NMR	NMR	NNP
cord-001835-0s7ok4uw	5104	19	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	5104	20	.	.	.
cord-001835-0s7ok4uw	5105	1	For	for	IN
cord-001835-0s7ok4uw	5105	2	the	the	DT
cord-001835-0s7ok4uw	5105	3	backbone	backbone	NN
cord-001835-0s7ok4uw	5105	4	assignment	assignment	NN
cord-001835-0s7ok4uw	5105	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	5105	6	used	use	VBD
cord-001835-0s7ok4uw	5105	7	slice	slice	NN
cord-001835-0s7ok4uw	5105	8	-	-	HYPH
cord-001835-0s7ok4uw	5105	9	selectively	selectively	RB
cord-001835-0s7ok4uw	5105	10	homonuclear	homonuclear	JJ
cord-001835-0s7ok4uw	5105	11	broadband	broadband	NN
cord-001835-0s7ok4uw	5105	12	decoupled	decouple	VBD
cord-001835-0s7ok4uw	5105	13	spectra	spectrum	NNS
cord-001835-0s7ok4uw	5105	14	along	along	IN
cord-001835-0s7ok4uw	5105	15	with	with	IN
cord-001835-0s7ok4uw	5105	16	standard	standard	JJ
cord-001835-0s7ok4uw	5105	17	experiments	experiment	NNS
cord-001835-0s7ok4uw	5105	18	.	.	.
cord-001835-0s7ok4uw	5106	1	Three	three	CD
cord-001835-0s7ok4uw	5106	2	-	-	HYPH
cord-001835-0s7ok4uw	5106	3	bond	bond	NN
cord-001835-0s7ok4uw	5106	4	scalar	scalar	NN
cord-001835-0s7ok4uw	5106	5	coupling	coupling	NN
cord-001835-0s7ok4uw	5106	6	constants	constant	NNS
cord-001835-0s7ok4uw	5106	7	were	be	VBD
cord-001835-0s7ok4uw	5106	8	obtained	obtain	VBN
cord-001835-0s7ok4uw	5106	9	through	through	IN
cord-001835-0s7ok4uw	5106	10	real	real	JJ
cord-001835-0s7ok4uw	5106	11	-	-	HYPH
cord-001835-0s7ok4uw	5106	12	time	time	NN
cord-001835-0s7ok4uw	5106	13	J	j	NN
cord-001835-0s7ok4uw	5106	14	-	-	HYPH
cord-001835-0s7ok4uw	5106	15	upscaling	upscale	VBG
cord-001835-0s7ok4uw	5106	16	experiments	experiment	NNS
cord-001835-0s7ok4uw	5106	17	.	.	.
cord-001835-0s7ok4uw	5107	1	With	with	IN
cord-001835-0s7ok4uw	5107	2	the	the	DT
cord-001835-0s7ok4uw	5107	3	backbone	backbone	NN
cord-001835-0s7ok4uw	5107	4	assignments	assignment	NNS
cord-001835-0s7ok4uw	5107	5	,	,	,
cord-001835-0s7ok4uw	5107	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	5107	7	have	have	VBP
cord-001835-0s7ok4uw	5107	8	the	the	DT
cord-001835-0s7ok4uw	5107	9	first	first	JJ
cord-001835-0s7ok4uw	5107	10	hand	hand	NN
cord-001835-0s7ok4uw	5107	11	evidence	evidence	NN
cord-001835-0s7ok4uw	5107	12	which	which	WDT
cord-001835-0s7ok4uw	5107	13	shows	show	VBZ
cord-001835-0s7ok4uw	5107	14	that	that	IN
cord-001835-0s7ok4uw	5107	15	his	-PRON-	PRP$
cord-001835-0s7ok4uw	5107	16	domain	domain	NN
cord-001835-0s7ok4uw	5107	17	is	be	VBZ
cord-001835-0s7ok4uw	5107	18	for	for	IN
cord-001835-0s7ok4uw	5107	19	the	the	DT
cord-001835-0s7ok4uw	5107	20	most	most	JJS
cord-001835-0s7ok4uw	5107	21	part	part	NN
cord-001835-0s7ok4uw	5107	22	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	5107	23	disordered	disordered	JJ
cord-001835-0s7ok4uw	5107	24	,	,	,
cord-001835-0s7ok4uw	5107	25	but	but	CC
cord-001835-0s7ok4uw	5107	26	contains	contain	VBZ
cord-001835-0s7ok4uw	5107	27	short	short	JJ
cord-001835-0s7ok4uw	5107	28	a	a	DT
cord-001835-0s7ok4uw	5107	29	-	-	HYPH
cord-001835-0s7ok4uw	5107	30	helical	helical	JJ
cord-001835-0s7ok4uw	5107	31	regions	region	NNS
cord-001835-0s7ok4uw	5107	32	.	.	.
cord-001835-0s7ok4uw	5108	1	Structural	structural	JJ
cord-001835-0s7ok4uw	5108	2	development	development	NN
cord-001835-0s7ok4uw	5108	3	,	,	,
cord-001835-0s7ok4uw	5108	4	interaction	interaction	NN
cord-001835-0s7ok4uw	5108	5	studies	study	NNS
cord-001835-0s7ok4uw	5108	6	to	to	TO
cord-001835-0s7ok4uw	5108	7	find	find	VB
cord-001835-0s7ok4uw	5108	8	the	the	DT
cord-001835-0s7ok4uw	5108	9	binding	bind	VBG
cord-001835-0s7ok4uw	5108	10	partner	partner	NN
cord-001835-0s7ok4uw	5108	11	and	and	CC
cord-001835-0s7ok4uw	5108	12	transition	transition	NN
cord-001835-0s7ok4uw	5108	13	of	of	IN
cord-001835-0s7ok4uw	5108	14	disorder	disorder	NN
cord-001835-0s7ok4uw	5108	15	to	to	TO
cord-001835-0s7ok4uw	5108	16	order	order	VB
cord-001835-0s7ok4uw	5108	17	orientation	orientation	NN
cord-001835-0s7ok4uw	5108	18	of	of	IN
cord-001835-0s7ok4uw	5108	19	this	this	DT
cord-001835-0s7ok4uw	5108	20	domain	domain	NN
cord-001835-0s7ok4uw	5108	21	will	will	MD
cord-001835-0s7ok4uw	5108	22	be	be	VB
cord-001835-0s7ok4uw	5108	23	further	further	RB
cord-001835-0s7ok4uw	5108	24	investigated	investigate	VBN
cord-001835-0s7ok4uw	5108	25	in	in	IN
cord-001835-0s7ok4uw	5108	26	this	this	DT
cord-001835-0s7ok4uw	5108	27	project	project	NN
cord-001835-0s7ok4uw	5108	28	.	.	.
cord-001835-0s7ok4uw	5109	1	Here	here	RB
cord-001835-0s7ok4uw	5109	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	5109	3	investigated	investigate	VBD
cord-001835-0s7ok4uw	5109	4	a	a	DT
cord-001835-0s7ok4uw	5109	5	model	model	NN
cord-001835-0s7ok4uw	5109	6	system	system	NN
cord-001835-0s7ok4uw	5109	7	where	where	WRB
cord-001835-0s7ok4uw	5109	8	mAb	mab	NN
cord-001835-0s7ok4uw	5109	9	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5109	10	is	be	VBZ
cord-001835-0s7ok4uw	5109	11	induced	induce	VBN
cord-001835-0s7ok4uw	5109	12	by	by	IN
cord-001835-0s7ok4uw	5109	13	increasing	increase	VBG
cord-001835-0s7ok4uw	5109	14	the	the	DT
cord-001835-0s7ok4uw	5109	15	ionic	ionic	JJ
cord-001835-0s7ok4uw	5109	16	strength	strength	NN
cord-001835-0s7ok4uw	5109	17	(	(	-LRB-
cord-001835-0s7ok4uw	5109	18	NaCl	NaCl	NNP
cord-001835-0s7ok4uw	5109	19	)	)	-RRB-
cord-001835-0s7ok4uw	5109	20	at	at	IN
cord-001835-0s7ok4uw	5109	21	low	low	JJ
cord-001835-0s7ok4uw	5109	22	pH.	ph.	NN
cord-001835-0s7ok4uw	5110	1	The	the	DT
cord-001835-0s7ok4uw	5110	2	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5110	3	depends	depend	VBZ
cord-001835-0s7ok4uw	5110	4	both	both	DT
cord-001835-0s7ok4uw	5110	5	on	on	IN
cord-001835-0s7ok4uw	5110	6	protein	protein	NN
cord-001835-0s7ok4uw	5110	7	and	and	CC
cord-001835-0s7ok4uw	5110	8	sodium	sodium	NN
cord-001835-0s7ok4uw	5110	9	chloride	chloride	NN
cord-001835-0s7ok4uw	5110	10	concentration	concentration	NN
cord-001835-0s7ok4uw	5110	11	.	.	.
cord-001835-0s7ok4uw	5111	1	With	with	IN
cord-001835-0s7ok4uw	5111	2	Nanoparticle	Nanoparticle	NNP
cord-001835-0s7ok4uw	5111	3	Tracking	Tracking	NNP
cord-001835-0s7ok4uw	5111	4	Analysis	Analysis	NNP
cord-001835-0s7ok4uw	5111	5	(	(	-LRB-
cord-001835-0s7ok4uw	5111	6	NTA	NTA	NNP
cord-001835-0s7ok4uw	5111	7	)	)	-RRB-
cord-001835-0s7ok4uw	5111	8	and	and	CC
cord-001835-0s7ok4uw	5111	9	Micro	Micro	NNP
cord-001835-0s7ok4uw	5111	10	Flow	Flow	NNP
cord-001835-0s7ok4uw	5111	11	Imaging	Imaging	NNP
cord-001835-0s7ok4uw	5111	12	(	(	-LRB-
cord-001835-0s7ok4uw	5111	13	MFI	MFI	NNP
cord-001835-0s7ok4uw	5111	14	)	)	-RRB-
cord-001835-0s7ok4uw	5112	1	the	the	DT
cord-001835-0s7ok4uw	5112	2	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5112	3	formation	formation	NN
cord-001835-0s7ok4uw	5112	4	was	be	VBD
cord-001835-0s7ok4uw	5112	5	further	further	RB
cord-001835-0s7ok4uw	5112	6	characterized	characterize	VBN
cord-001835-0s7ok4uw	5112	7	.	.	.
cord-001835-0s7ok4uw	5113	1	Aggregation	aggregation	NN
cord-001835-0s7ok4uw	5113	2	can	can	MD
cord-001835-0s7ok4uw	5113	3	be	be	VB
cord-001835-0s7ok4uw	5113	4	partially	partially	RB
cord-001835-0s7ok4uw	5113	5	reverted	revert	VBN
cord-001835-0s7ok4uw	5113	6	by	by	IN
cord-001835-0s7ok4uw	5113	7	lowering	lower	VBG
cord-001835-0s7ok4uw	5113	8	the	the	DT
cord-001835-0s7ok4uw	5113	9	ionic	ionic	JJ
cord-001835-0s7ok4uw	5113	10	strength	strength	NN
cord-001835-0s7ok4uw	5113	11	as	as	IN
cord-001835-0s7ok4uw	5113	12	determined	determine	VBN
cord-001835-0s7ok4uw	5113	13	by	by	IN
cord-001835-0s7ok4uw	5113	14	soluble	soluble	JJ
cord-001835-0s7ok4uw	5113	15	monomer	monomer	NN
cord-001835-0s7ok4uw	5113	16	concentration	concentration	NN
cord-001835-0s7ok4uw	5113	17	measurement	measurement	NN
cord-001835-0s7ok4uw	5113	18	using	use	VBG
cord-001835-0s7ok4uw	5113	19	SE	SE	NNP
cord-001835-0s7ok4uw	5113	20	-	-	HYPH
cord-001835-0s7ok4uw	5113	21	HPLC	HPLC	NNP
cord-001835-0s7ok4uw	5113	22	:	:	:
cord-001835-0s7ok4uw	5113	23	Parts	part	NNS
cord-001835-0s7ok4uw	5113	24	of	of	IN
cord-001835-0s7ok4uw	5113	25	insoluble	insoluble	JJ
cord-001835-0s7ok4uw	5113	26	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	5113	27	could	could	MD
cord-001835-0s7ok4uw	5113	28	be	be	VB
cord-001835-0s7ok4uw	5113	29	solubilized	solubilize	VBN
cord-001835-0s7ok4uw	5113	30	as	as	IN
cord-001835-0s7ok4uw	5113	31	soluble	soluble	JJ
cord-001835-0s7ok4uw	5113	32	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	5113	33	,	,	,
cord-001835-0s7ok4uw	5113	34	dimers	dimer	NNS
cord-001835-0s7ok4uw	5113	35	or	or	CC
cord-001835-0s7ok4uw	5113	36	even	even	RB
cord-001835-0s7ok4uw	5113	37	monomers	monomer	NNS
cord-001835-0s7ok4uw	5113	38	.	.	.
cord-001835-0s7ok4uw	5114	1	A	a	DT
cord-001835-0s7ok4uw	5114	2	quasi	quasi	JJ
cord-001835-0s7ok4uw	5114	3	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	5114	4	is	be	VBZ
cord-001835-0s7ok4uw	5114	5	formed	form	VBN
cord-001835-0s7ok4uw	5114	6	in	in	RP
cord-001835-0s7ok4uw	5114	7	between	between	IN
cord-001835-0s7ok4uw	5114	8	the	the	DT
cord-001835-0s7ok4uw	5114	9	subtypes	subtype	NNS
cord-001835-0s7ok4uw	5114	10	.	.	.
cord-001835-0s7ok4uw	5115	1	The	the	DT
cord-001835-0s7ok4uw	5115	2	whole	whole	JJ
cord-001835-0s7ok4uw	5115	3	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5115	4	process	process	NN
cord-001835-0s7ok4uw	5115	5	was	be	VBD
cord-001835-0s7ok4uw	5115	6	examined	examine	VBN
cord-001835-0s7ok4uw	5115	7	by	by	IN
cord-001835-0s7ok4uw	5115	8	FTIR	FTIR	NNP
cord-001835-0s7ok4uw	5115	9	and	and	CC
cord-001835-0s7ok4uw	5115	10	CD	CD	NNP
cord-001835-0s7ok4uw	5115	11	-	-	HYPH
cord-001835-0s7ok4uw	5115	12	Spectroscopy	Spectroscopy	NNP
cord-001835-0s7ok4uw	5115	13	to	to	TO
cord-001835-0s7ok4uw	5115	14	identify	identify	VB
cord-001835-0s7ok4uw	5115	15	structural	structural	JJ
cord-001835-0s7ok4uw	5115	16	changes	change	NNS
cord-001835-0s7ok4uw	5115	17	of	of	IN
cord-001835-0s7ok4uw	5115	18	the	the	DT
cord-001835-0s7ok4uw	5115	19	mAb	mAb	NNS
cord-001835-0s7ok4uw	5115	20	.	.	.
cord-001835-0s7ok4uw	5116	1	Screen	screen	NN
cord-001835-0s7ok4uw	5116	2	of	of	IN
cord-001835-0s7ok4uw	5116	3	protective	protective	JJ
cord-001835-0s7ok4uw	5116	4	additives	additive	NNS
cord-001835-0s7ok4uw	5116	5	:	:	:
cord-001835-0s7ok4uw	5116	6	The	the	DT
cord-001835-0s7ok4uw	5116	7	effect	effect	NN
cord-001835-0s7ok4uw	5116	8	of	of	IN
cord-001835-0s7ok4uw	5116	9	osmolyte	osmolyte	JJ
cord-001835-0s7ok4uw	5116	10	additives	additive	NNS
cord-001835-0s7ok4uw	5116	11	on	on	IN
cord-001835-0s7ok4uw	5116	12	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5116	13	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	5116	14	and	and	CC
cord-001835-0s7ok4uw	5116	15	final	final	JJ
cord-001835-0s7ok4uw	5116	16	aggregate	aggregate	JJ
cord-001835-0s7ok4uw	5116	17	concentration	concentration	NN
cord-001835-0s7ok4uw	5116	18	is	be	VBZ
cord-001835-0s7ok4uw	5116	19	investigated	investigate	VBN
cord-001835-0s7ok4uw	5116	20	,	,	,
cord-001835-0s7ok4uw	5116	21	revealing	reveal	VBG
cord-001835-0s7ok4uw	5116	22	protective	protective	JJ
cord-001835-0s7ok4uw	5116	23	effects	effect	NNS
cord-001835-0s7ok4uw	5116	24	in	in	IN
cord-001835-0s7ok4uw	5116	25	both	both	DT
cord-001835-0s7ok4uw	5116	26	cases	case	NNS
cord-001835-0s7ok4uw	5116	27	.	.	.
cord-001835-0s7ok4uw	5117	1	In	in	IN
cord-001835-0s7ok4uw	5117	2	a	a	DT
cord-001835-0s7ok4uw	5117	3	screen	screen	NN
cord-001835-0s7ok4uw	5117	4	with	with	IN
cord-001835-0s7ok4uw	5117	5	more	more	JJR
cord-001835-0s7ok4uw	5117	6	than	than	IN
cord-001835-0s7ok4uw	5117	7	200	200	CD
cord-001835-0s7ok4uw	5117	8	compounds	compound	NNS
cord-001835-0s7ok4uw	5117	9	not	not	RB
cord-001835-0s7ok4uw	5117	10	only	only	RB
cord-001835-0s7ok4uw	5117	11	the	the	DT
cord-001835-0s7ok4uw	5117	12	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5117	13	propensity	propensity	NN
cord-001835-0s7ok4uw	5117	14	was	be	VBD
cord-001835-0s7ok4uw	5117	15	studied	study	VBN
cord-001835-0s7ok4uw	5117	16	but	but	CC
cord-001835-0s7ok4uw	5117	17	also	also	RB
cord-001835-0s7ok4uw	5117	18	structural	structural	JJ
cord-001835-0s7ok4uw	5117	19	changes	change	NNS
cord-001835-0s7ok4uw	5117	20	.	.	.
cord-001835-0s7ok4uw	5118	1	The	the	DT
cord-001835-0s7ok4uw	5118	2	Aggregation	Aggregation	NNP
cord-001835-0s7ok4uw	5118	3	Index	Index	NNP
cord-001835-0s7ok4uw	5118	4	(	(	-LRB-
cord-001835-0s7ok4uw	5118	5	quantity	quantity	NN
cord-001835-0s7ok4uw	5118	6	for	for	IN
cord-001835-0s7ok4uw	5118	7	colloidal	colloidal	NN
cord-001835-0s7ok4uw	5118	8	stability	stability	NN
cord-001835-0s7ok4uw	5118	9	)	)	-RRB-
cord-001835-0s7ok4uw	5118	10	and	and	CC
cord-001835-0s7ok4uw	5118	11	the	the	DT
cord-001835-0s7ok4uw	5118	12	melting	melting	NN
cord-001835-0s7ok4uw	5118	13	point	point	NN
cord-001835-0s7ok4uw	5118	14	(	(	-LRB-
cord-001835-0s7ok4uw	5118	15	quantity	quantity	NN
cord-001835-0s7ok4uw	5118	16	for	for	IN
cord-001835-0s7ok4uw	5118	17	conformational	conformational	JJ
cord-001835-0s7ok4uw	5118	18	stability	stability	NN
cord-001835-0s7ok4uw	5118	19	)	)	-RRB-
cord-001835-0s7ok4uw	5118	20	measured	measure	VBN
cord-001835-0s7ok4uw	5118	21	by	by	IN
cord-001835-0s7ok4uw	5118	22	differential	differential	JJ
cord-001835-0s7ok4uw	5118	23	scanning	scanning	NN
cord-001835-0s7ok4uw	5118	24	fluorimetry	fluorimetry	NN
cord-001835-0s7ok4uw	5118	25	were	be	VBD
cord-001835-0s7ok4uw	5118	26	determined	determine	VBN
cord-001835-0s7ok4uw	5118	27	.	.	.
cord-001835-0s7ok4uw	5119	1	The	the	DT
cord-001835-0s7ok4uw	5119	2	used	used	JJ
cord-001835-0s7ok4uw	5119	3	MTP	MTP	NNP
cord-001835-0s7ok4uw	5119	4	format	format	NN
cord-001835-0s7ok4uw	5119	5	screen	screen	NN
cord-001835-0s7ok4uw	5119	6	has	have	VBZ
cord-001835-0s7ok4uw	5119	7	potential	potential	NN
cord-001835-0s7ok4uw	5119	8	for	for	IN
cord-001835-0s7ok4uw	5119	9	buffer	buffer	NN
cord-001835-0s7ok4uw	5119	10	optimization	optimization	NN
cord-001835-0s7ok4uw	5119	11	and	and	CC
cord-001835-0s7ok4uw	5119	12	formulation	formulation	NN
cord-001835-0s7ok4uw	5119	13	development	development	NN
cord-001835-0s7ok4uw	5119	14	.	.	.
cord-001835-0s7ok4uw	5120	1	Structural	structural	JJ
cord-001835-0s7ok4uw	5120	2	Biology	Biology	NNP
cord-001835-0s7ok4uw	5120	3	and	and	CC
cord-001835-0s7ok4uw	5120	4	Protein	Protein	NNP
cord-001835-0s7ok4uw	5120	5	Dynamics	Dynamics	NNPS
cord-001835-0s7ok4uw	5121	1	Tetraspanin	Tetraspanin	NNP
cord-001835-0s7ok4uw	5121	2	CD81	CD81	NNP
cord-001835-0s7ok4uw	5121	3	has	have	VBZ
cord-001835-0s7ok4uw	5121	4	a	a	DT
cord-001835-0s7ok4uw	5121	5	broad	broad	JJ
cord-001835-0s7ok4uw	5121	6	range	range	NN
cord-001835-0s7ok4uw	5121	7	of	of	IN
cord-001835-0s7ok4uw	5121	8	cellular	cellular	JJ
cord-001835-0s7ok4uw	5121	9	functions	function	NNS
cord-001835-0s7ok4uw	5121	10	,	,	,
cord-001835-0s7ok4uw	5121	11	such	such	JJ
cord-001835-0s7ok4uw	5121	12	as	as	IN
cord-001835-0s7ok4uw	5121	13	integrin	integrin	NNP
cord-001835-0s7ok4uw	5121	14	association	association	NN
cord-001835-0s7ok4uw	5121	15	forming	form	VBG
cord-001835-0s7ok4uw	5121	16	tetraspanin	tetraspanin	NNP
cord-001835-0s7ok4uw	5121	17	-	-	HYPH
cord-001835-0s7ok4uw	5121	18	enriched	enrich	VBN
cord-001835-0s7ok4uw	5121	19	domains	domain	NNS
cord-001835-0s7ok4uw	5121	20	,	,	,
cord-001835-0s7ok4uw	5121	21	synapse	synapse	NN
cord-001835-0s7ok4uw	5121	22	formation	formation	NN
cord-001835-0s7ok4uw	5121	23	between	between	IN
cord-001835-0s7ok4uw	5121	24	B	B	NNP
cord-001835-0s7ok4uw	5121	25	and	and	CC
cord-001835-0s7ok4uw	5121	26	T	t	NN
cord-001835-0s7ok4uw	5121	27	cells	cell	NNS
cord-001835-0s7ok4uw	5121	28	,	,	,
cord-001835-0s7ok4uw	5121	29	cell	cell	NN
cord-001835-0s7ok4uw	5121	30	adhesion	adhesion	NN
cord-001835-0s7ok4uw	5121	31	,	,	,
cord-001835-0s7ok4uw	5121	32	motility	motility	NN
cord-001835-0s7ok4uw	5121	33	,	,	,
cord-001835-0s7ok4uw	5121	34	invasion	invasion	NN
cord-001835-0s7ok4uw	5121	35	and	and	CC
cord-001835-0s7ok4uw	5121	36	signalling	signalling	NN
cord-001835-0s7ok4uw	5121	37	.	.	.
cord-001835-0s7ok4uw	5122	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	5122	2	,	,	,
cord-001835-0s7ok4uw	5122	3	CD81	CD81	NNP
cord-001835-0s7ok4uw	5122	4	is	be	VBZ
cord-001835-0s7ok4uw	5122	5	one	one	CD
cord-001835-0s7ok4uw	5122	6	of	of	IN
cord-001835-0s7ok4uw	5122	7	the	the	DT
cord-001835-0s7ok4uw	5122	8	four	four	CD
cord-001835-0s7ok4uw	5122	9	receptors	receptor	NNS
cord-001835-0s7ok4uw	5122	10	involved	involve	VBN
cord-001835-0s7ok4uw	5122	11	in	in	IN
cord-001835-0s7ok4uw	5122	12	the	the	DT
cord-001835-0s7ok4uw	5122	13	cell	cell	NN
cord-001835-0s7ok4uw	5122	14	entry	entry	NN
cord-001835-0s7ok4uw	5122	15	of	of	IN
cord-001835-0s7ok4uw	5122	16	Hepatitis	Hepatitis	NNP
cord-001835-0s7ok4uw	5122	17	C	C	NNP
cord-001835-0s7ok4uw	5122	18	virus	virus	NN
cord-001835-0s7ok4uw	5122	19	(	(	-LRB-
cord-001835-0s7ok4uw	5122	20	HCV	HCV	NNP
cord-001835-0s7ok4uw	5122	21	)	)	-RRB-
cord-001835-0s7ok4uw	5122	22	and	and	CC
cord-001835-0s7ok4uw	5122	23	therefore	therefore	RB
cord-001835-0s7ok4uw	5122	24	infection	infection	NN
cord-001835-0s7ok4uw	5122	25	onset	onset	NN
cord-001835-0s7ok4uw	5122	26	,	,	,
cord-001835-0s7ok4uw	5122	27	one	one	CD
cord-001835-0s7ok4uw	5122	28	of	of	IN
cord-001835-0s7ok4uw	5122	29	the	the	DT
cord-001835-0s7ok4uw	5122	30	major	major	JJ
cord-001835-0s7ok4uw	5122	31	causes	cause	NNS
cord-001835-0s7ok4uw	5122	32	for	for	IN
cord-001835-0s7ok4uw	5122	33	chronic	chronic	JJ
cord-001835-0s7ok4uw	5122	34	liver	liver	NN
cord-001835-0s7ok4uw	5122	35	disease	disease	NN
cord-001835-0s7ok4uw	5122	36	resulting	result	VBG
cord-001835-0s7ok4uw	5122	37	in	in	IN
cord-001835-0s7ok4uw	5122	38	cirrhosis	cirrhosis	NN
cord-001835-0s7ok4uw	5122	39	and	and	CC
cord-001835-0s7ok4uw	5122	40	hepatocarcinoma	hepatocarcinoma	NNP
cord-001835-0s7ok4uw	5122	41	.	.	.
cord-001835-0s7ok4uw	5123	1	Human	human	JJ
cord-001835-0s7ok4uw	5123	2	CD81	CD81	NNP
cord-001835-0s7ok4uw	5123	3	Large	Large	NNP
cord-001835-0s7ok4uw	5123	4	-	-	HYPH
cord-001835-0s7ok4uw	5123	5	Extracellular	Extracellular	NNP
cord-001835-0s7ok4uw	5123	6	-	-	HYPH
cord-001835-0s7ok4uw	5123	7	Loop	Loop	NNP
cord-001835-0s7ok4uw	5123	8	(	(	-LRB-
cord-001835-0s7ok4uw	5123	9	hCD81LEL	hCD81LEL	NNP
cord-001835-0s7ok4uw	5123	10	)	)	-RRB-
cord-001835-0s7ok4uw	5123	11	is	be	VBZ
cord-001835-0s7ok4uw	5123	12	composed	compose	VBN
cord-001835-0s7ok4uw	5123	13	of	of	IN
cord-001835-0s7ok4uw	5123	14	a	a	DT
cord-001835-0s7ok4uw	5123	15	"	"	``
cord-001835-0s7ok4uw	5123	16	stalk	stalk	NN
cord-001835-0s7ok4uw	5123	17	"	"	''
cord-001835-0s7ok4uw	5123	18	and	and	CC
cord-001835-0s7ok4uw	5123	19	a	a	DT
cord-001835-0s7ok4uw	5123	20	"	"	``
cord-001835-0s7ok4uw	5123	21	head	head	NN
cord-001835-0s7ok4uw	5123	22	"	"	''
cord-001835-0s7ok4uw	5123	23	subdomain	subdomain	NN
cord-001835-0s7ok4uw	5123	24	;	;	:
cord-001835-0s7ok4uw	5123	25	with	with	IN
cord-001835-0s7ok4uw	5123	26	the	the	DT
cord-001835-0s7ok4uw	5123	27	latter	latter	JJ
cord-001835-0s7ok4uw	5123	28	interacting	interact	VBG
cord-001835-0s7ok4uw	5123	29	with	with	IN
cord-001835-0s7ok4uw	5123	30	HCV	HCV	NNP
cord-001835-0s7ok4uw	5123	31	-	-	HYPH
cord-001835-0s7ok4uw	5123	32	E2	E2	NNP
cord-001835-0s7ok4uw	5123	33	glycoprotein	glycoprotein	NN
cord-001835-0s7ok4uw	5123	34	.	.	.
cord-001835-0s7ok4uw	5124	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5124	2	present	present	VBP
cord-001835-0s7ok4uw	5124	3	four	four	CD
cord-001835-0s7ok4uw	5124	4	novel	novel	NN
cord-001835-0s7ok4uw	5124	5	hCD81LEL	hcd81lel	NN
cord-001835-0s7ok4uw	5124	6	crystal	crystal	NNP
cord-001835-0s7ok4uw	5124	7	forms	form	NNS
cord-001835-0s7ok4uw	5124	8	.	.	.
cord-001835-0s7ok4uw	5125	1	Analysis	analysis	NN
cord-001835-0s7ok4uw	5125	2	of	of	IN
cord-001835-0s7ok4uw	5125	3	the	the	DT
cord-001835-0s7ok4uw	5125	4	fourteen	fourteen	CD
cord-001835-0s7ok4uw	5125	5	independent	independent	NN
cord-001835-0s7ok4uw	5125	6	observed	observe	VBD
cord-001835-0s7ok4uw	5125	7	hCD81LEL	hcd81lel	NN
cord-001835-0s7ok4uw	5125	8	high	high	JJ
cord-001835-0s7ok4uw	5125	9	-	-	HYPH
cord-001835-0s7ok4uw	5125	10	resolution	resolution	NN
cord-001835-0s7ok4uw	5125	11	X	x	NN
cord-001835-0s7ok4uw	5125	12	-	-	NN
cord-001835-0s7ok4uw	5125	13	ray	ray	NN
cord-001835-0s7ok4uw	5125	14	structures	structure	NNS
cord-001835-0s7ok4uw	5125	15	suggests	suggest	VBZ
cord-001835-0s7ok4uw	5125	16	that	that	IN
cord-001835-0s7ok4uw	5125	17	the	the	DT
cord-001835-0s7ok4uw	5125	18	dynamism	dynamism	NN
cord-001835-0s7ok4uw	5125	19	of	of	IN
cord-001835-0s7ok4uw	5125	20	the	the	DT
cord-001835-0s7ok4uw	5125	21	hCD81LEL	hcd81lel	NN
cord-001835-0s7ok4uw	5125	22	head	head	NN
cord-001835-0s7ok4uw	5125	23	-	-	HYPH
cord-001835-0s7ok4uw	5125	24	subdomain	subdomain	NN
cord-001835-0s7ok4uw	5125	25	is	be	VBZ
cord-001835-0s7ok4uw	5125	26	an	an	DT
cord-001835-0s7ok4uw	5125	27	inherent	inherent	JJ
cord-001835-0s7ok4uw	5125	28	molecular	molecular	JJ
cord-001835-0s7ok4uw	5125	29	property	property	NN
cord-001835-0s7ok4uw	5125	30	,	,	,
cord-001835-0s7ok4uw	5125	31	an	an	DT
cord-001835-0s7ok4uw	5125	32	observation	observation	NN
cord-001835-0s7ok4uw	5125	33	supported	support	VBN
cord-001835-0s7ok4uw	5125	34	also	also	RB
cord-001835-0s7ok4uw	5125	35	by	by	IN
cord-001835-0s7ok4uw	5125	36	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	5125	37	Dynamics	Dynamics	NNP
cord-001835-0s7ok4uw	5125	38	(	(	-LRB-
cord-001835-0s7ok4uw	5125	39	MD	MD	NNP
cord-001835-0s7ok4uw	5125	40	)	)	-RRB-
cord-001835-0s7ok4uw	5125	41	studies	study	NNS
cord-001835-0s7ok4uw	5125	42	.	.	.
cord-001835-0s7ok4uw	5126	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5126	2	classify	classify	VBP
cord-001835-0s7ok4uw	5126	3	the	the	DT
cord-001835-0s7ok4uw	5126	4	conformations	conformation	NNS
cord-001835-0s7ok4uw	5126	5	in	in	IN
cord-001835-0s7ok4uw	5126	6	three	three	CD
cord-001835-0s7ok4uw	5126	7	distinct	distinct	JJ
cord-001835-0s7ok4uw	5126	8	clusters	cluster	NNS
cord-001835-0s7ok4uw	5126	9	(	(	-LRB-
cord-001835-0s7ok4uw	5126	10	closed	closed	JJ
cord-001835-0s7ok4uw	5126	11	,	,	,
cord-001835-0s7ok4uw	5126	12	intermediate	intermediate	JJ
cord-001835-0s7ok4uw	5126	13	 	 	_SP
cord-001835-0s7ok4uw	5126	14	and	and	CC
cord-001835-0s7ok4uw	5126	15	open	open	JJ
cord-001835-0s7ok4uw	5126	16	)	)	-RRB-
cord-001835-0s7ok4uw	5126	17	,	,	,
cord-001835-0s7ok4uw	5126	18	which	which	WDT
cord-001835-0s7ok4uw	5126	19	are	be	VBP
cord-001835-0s7ok4uw	5126	20	seen	see	VBN
cord-001835-0s7ok4uw	5126	21	both	both	CC
cord-001835-0s7ok4uw	5126	22	in	in	IN
cord-001835-0s7ok4uw	5126	23	the	the	DT
cord-001835-0s7ok4uw	5126	24	crystal	crystal	NN
cord-001835-0s7ok4uw	5126	25	structures	structure	NNS
cord-001835-0s7ok4uw	5126	26	and	and	CC
cord-001835-0s7ok4uw	5126	27	in	in	IN
cord-001835-0s7ok4uw	5126	28	the	the	DT
cord-001835-0s7ok4uw	5126	29	molecular	molecular	JJ
cord-001835-0s7ok4uw	5126	30	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	5126	31	simulations	simulation	NNS
cord-001835-0s7ok4uw	5126	32	.	.	.
cord-001835-0s7ok4uw	5127	1	The	the	DT
cord-001835-0s7ok4uw	5127	2	MD	MD	NNP
cord-001835-0s7ok4uw	5127	3	simulations	simulation	NNS
cord-001835-0s7ok4uw	5127	4	also	also	RB
cord-001835-0s7ok4uw	5127	5	show	show	VBP
cord-001835-0s7ok4uw	5127	6	that	that	IN
cord-001835-0s7ok4uw	5127	7	conformational	conformational	JJ
cord-001835-0s7ok4uw	5127	8	variability	variability	NN
cord-001835-0s7ok4uw	5127	9	is	be	VBZ
cord-001835-0s7ok4uw	5127	10	modulated	modulate	VBN
cord-001835-0s7ok4uw	5127	11	by	by	IN
cord-001835-0s7ok4uw	5127	12	pH	pH	NNP
cord-001835-0s7ok4uw	5127	13	changes	change	NNS
cord-001835-0s7ok4uw	5127	14	,	,	,
cord-001835-0s7ok4uw	5127	15	with	with	IN
cord-001835-0s7ok4uw	5127	16	distinct	distinct	JJ
cord-001835-0s7ok4uw	5127	17	probability	probability	NN
cord-001835-0s7ok4uw	5127	18	for	for	IN
cord-001835-0s7ok4uw	5127	19	each	each	DT
cord-001835-0s7ok4uw	5127	20	cluster	cluster	NN
cord-001835-0s7ok4uw	5127	21	at	at	IN
cord-001835-0s7ok4uw	5127	22	acidic	acidic	JJ
cord-001835-0s7ok4uw	5127	23	and	and	CC
cord-001835-0s7ok4uw	5127	24	neutral	neutral	JJ
cord-001835-0s7ok4uw	5127	25	pH.	ph.	NN
cord-001835-0s7ok4uw	5128	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	5128	2	,	,	,
cord-001835-0s7ok4uw	5128	3	in	in	IN
cord-001835-0s7ok4uw	5128	4	silico	silico	NN
cord-001835-0s7ok4uw	5128	5	docking	docking	NN
cord-001835-0s7ok4uw	5128	6	of	of	IN
cord-001835-0s7ok4uw	5128	7	the	the	DT
cord-001835-0s7ok4uw	5128	8	recent	recent	JJ
cord-001835-0s7ok4uw	5128	9	E2core	E2core	NNP
cord-001835-0s7ok4uw	5128	10	structure	structure	NN
cord-001835-0s7ok4uw	5128	11	with	with	IN
cord-001835-0s7ok4uw	5128	12	three	three	CD
cord-001835-0s7ok4uw	5128	13	of	of	IN
cord-001835-0s7ok4uw	5128	14	the	the	DT
cord-001835-0s7ok4uw	5128	15	major	major	JJ
cord-001835-0s7ok4uw	5128	16	types	type	NNS
cord-001835-0s7ok4uw	5128	17	of	of	IN
cord-001835-0s7ok4uw	5128	18	hCD81LEL	hcd81lel	NN
cord-001835-0s7ok4uw	5128	19	head	head	NN
cord-001835-0s7ok4uw	5128	20	-	-	HYPH
cord-001835-0s7ok4uw	5128	21	subdomain	subdomain	NN
cord-001835-0s7ok4uw	5128	22	clusters	cluster	NNS
cord-001835-0s7ok4uw	5128	23	highlights	highlight	VBZ
cord-001835-0s7ok4uw	5128	24	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5128	25	interactions	interaction	NNS
cord-001835-0s7ok4uw	5128	26	as	as	IN
cord-001835-0s7ok4uw	5128	27	the	the	DT
cord-001835-0s7ok4uw	5128	28	major	major	JJ
cord-001835-0s7ok4uw	5128	29	forces	force	NNS
cord-001835-0s7ok4uw	5128	30	in	in	IN
cord-001835-0s7ok4uw	5128	31	the	the	DT
cord-001835-0s7ok4uw	5128	32	E2core	E2core	NNP
cord-001835-0s7ok4uw	5128	33	:	:	:
cord-001835-0s7ok4uw	5128	34	hCD81LEL	hCD81LEL	NNP
cord-001835-0s7ok4uw	5128	35	recognition	recognition	NN
cord-001835-0s7ok4uw	5128	36	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5128	37	.	.	.
cord-001835-0s7ok4uw	5129	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5129	2	propose	propose	VBP
cord-001835-0s7ok4uw	5129	3	that	that	IN
cord-001835-0s7ok4uw	5129	4	the	the	DT
cord-001835-0s7ok4uw	5129	5	flexibility	flexibility	NN
cord-001835-0s7ok4uw	5129	6	of	of	IN
cord-001835-0s7ok4uw	5129	7	the	the	DT
cord-001835-0s7ok4uw	5129	8	hCD81LEL	hcd81lel	NN
cord-001835-0s7ok4uw	5129	9	is	be	VBZ
cord-001835-0s7ok4uw	5129	10	exploited	exploit	VBN
cord-001835-0s7ok4uw	5129	11	by	by	IN
cord-001835-0s7ok4uw	5129	12	HCV	HCV	NNP
cord-001835-0s7ok4uw	5129	13	at	at	IN
cord-001835-0s7ok4uw	5129	14	different	different	JJ
cord-001835-0s7ok4uw	5129	15	stages	stage	NNS
cord-001835-0s7ok4uw	5129	16	of	of	IN
cord-001835-0s7ok4uw	5129	17	cell	cell	NN
cord-001835-0s7ok4uw	5129	18	entry	entry	NN
cord-001835-0s7ok4uw	5129	19	from	from	IN
cord-001835-0s7ok4uw	5129	20	virus	virus	NN
cord-001835-0s7ok4uw	5129	21	attachment	attachment	NN
cord-001835-0s7ok4uw	5129	22	to	to	IN
cord-001835-0s7ok4uw	5129	23	internalization	internalization	NN
cord-001835-0s7ok4uw	5129	24	and	and	CC
cord-001835-0s7ok4uw	5129	25	fusion	fusion	NN
cord-001835-0s7ok4uw	5129	26	with	with	IN
cord-001835-0s7ok4uw	5129	27	the	the	DT
cord-001835-0s7ok4uw	5129	28	endosomal	endosomal	NNP
cord-001835-0s7ok4uw	5129	29	membrane	membrane	NN
cord-001835-0s7ok4uw	5129	30	.	.	.
cord-001835-0s7ok4uw	5130	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	5130	2	results	result	NNS
cord-001835-0s7ok4uw	5130	3	provide	provide	VBP
cord-001835-0s7ok4uw	5130	4	important	important	JJ
cord-001835-0s7ok4uw	5130	5	insights	insight	NNS
cord-001835-0s7ok4uw	5130	6	on	on	IN
cord-001835-0s7ok4uw	5130	7	the	the	DT
cord-001835-0s7ok4uw	5130	8	basic	basic	JJ
cord-001835-0s7ok4uw	5130	9	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5130	10	governing	govern	VBG
cord-001835-0s7ok4uw	5130	11	HCV	HCV	NNP
cord-001835-0s7ok4uw	5130	12	binding	bind	VBG
cord-001835-0s7ok4uw	5130	13	to	to	IN
cord-001835-0s7ok4uw	5130	14	hCD81	hCD81	NNP
cord-001835-0s7ok4uw	5130	15	,	,	,
cord-001835-0s7ok4uw	5130	16	and	and	CC
cord-001835-0s7ok4uw	5130	17	can	can	MD
cord-001835-0s7ok4uw	5130	18	help	help	VB
cord-001835-0s7ok4uw	5130	19	structure	structure	NN
cord-001835-0s7ok4uw	5130	20	-	-	HYPH
cord-001835-0s7ok4uw	5130	21	based	base	VBN
cord-001835-0s7ok4uw	5130	22	drug	drug	NN
cord-001835-0s7ok4uw	5130	23	design	design	NN
cord-001835-0s7ok4uw	5130	24	of	of	IN
cord-001835-0s7ok4uw	5130	25	entryinhibitors	entryinhibitor	NNS
cord-001835-0s7ok4uw	5130	26	of	of	IN
cord-001835-0s7ok4uw	5130	27	HCV	HCV	NNP
cord-001835-0s7ok4uw	5130	28	.	.	.
cord-001835-0s7ok4uw	5131	1	Allophycocyanin	Allophycocyanin	NNP
cord-001835-0s7ok4uw	5131	2	of	of	IN
cord-001835-0s7ok4uw	5131	3	gracilaria	gracilaria	NNP
cord-001835-0s7ok4uw	5131	4	chilensis	chilensis	NNP
cord-001835-0s7ok4uw	5131	5	:	:	:
cord-001835-0s7ok4uw	5131	6	from	from	IN
cord-001835-0s7ok4uw	5131	7	gene	gene	NN
cord-001835-0s7ok4uw	5131	8	to	to	TO
cord-001835-0s7ok4uw	5131	9	function	function	VB
cord-001835-0s7ok4uw	5131	10	Jorge	Jorge	NNP
cord-001835-0s7ok4uw	5131	11	Dagnino	Dagnino	NNP
cord-001835-0s7ok4uw	5131	12	-	-	HYPH
cord-001835-0s7ok4uw	5131	13	Leone	Leone	NNP
cord-001835-0s7ok4uw	5131	14	1	1	CD
cord-001835-0s7ok4uw	5131	15	,	,	,
cord-001835-0s7ok4uw	5131	16	Jos	Jos	NNP
cord-001835-0s7ok4uw	5131	17	e	e	NNP
cord-001835-0s7ok4uw	5131	18	Martinez	Martinez	NNP
cord-001835-0s7ok4uw	5131	19	-	-	HYPH
cord-001835-0s7ok4uw	5131	20	Oyanedel	Oyanedel	NNP
cord-001835-0s7ok4uw	5131	21	1	1	CD
cord-001835-0s7ok4uw	5131	22	,	,	,
cord-001835-0s7ok4uw	5131	23	Marta	Marta	NNP
cord-001835-0s7ok4uw	5131	24	Bunster	Bunster	NNP
cord-001835-0s7ok4uw	5131	25	-	-	HYPH
cord-001835-0s7ok4uw	5131	26	Balocchi	Balocchi	NNP
cord-001835-0s7ok4uw	5131	27	1	1	CD
cord-001835-0s7ok4uw	5131	28	1	1	CD
cord-001835-0s7ok4uw	5131	29	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	5131	30	de	de	IN
cord-001835-0s7ok4uw	5131	31	Concepci	Concepci	NNP
cord-001835-0s7ok4uw	5131	32	on	on	IN
cord-001835-0s7ok4uw	5131	33	THEME	theme	NN
cord-001835-0s7ok4uw	5131	34	:	:	:
cord-001835-0s7ok4uw	5132	1	Structure	structure	NN
cord-001835-0s7ok4uw	5132	2	-	-	HYPH
cord-001835-0s7ok4uw	5132	3	Function	Function	NNP
cord-001835-0s7ok4uw	5132	4	relationship	relationship	NN
cord-001835-0s7ok4uw	5132	5	of	of	IN
cord-001835-0s7ok4uw	5132	6	proteins	protein	NNS
cord-001835-0s7ok4uw	5133	1	The	the	DT
cord-001835-0s7ok4uw	5133	2	phycobilisomes	phycobilisome	NNS
cord-001835-0s7ok4uw	5133	3	(	(	-LRB-
cord-001835-0s7ok4uw	5133	4	PBS	PBS	NNP
cord-001835-0s7ok4uw	5133	5	)	)	-RRB-
cord-001835-0s7ok4uw	5133	6	are	be	VBP
cord-001835-0s7ok4uw	5133	7	auxiliary	auxiliary	JJ
cord-001835-0s7ok4uw	5133	8	photosynthetic	photosynthetic	JJ
cord-001835-0s7ok4uw	5133	9	complexes	complex	NNS
cord-001835-0s7ok4uw	5133	10	that	that	WDT
cord-001835-0s7ok4uw	5133	11	allow	allow	VBP
cord-001835-0s7ok4uw	5133	12	cyanobacteria	cyanobacteria	NNS
cord-001835-0s7ok4uw	5133	13	and	and	CC
cord-001835-0s7ok4uw	5133	14	red	red	JJ
cord-001835-0s7ok4uw	5133	15	algae	algae	NN
cord-001835-0s7ok4uw	5133	16	to	to	TO
cord-001835-0s7ok4uw	5133	17	enhance	enhance	VB
cord-001835-0s7ok4uw	5133	18	the	the	DT
cord-001835-0s7ok4uw	5133	19	energy	energy	NN
cord-001835-0s7ok4uw	5133	20	uptake	uptake	NN
cord-001835-0s7ok4uw	5133	21	in	in	IN
cord-001835-0s7ok4uw	5133	22	the	the	DT
cord-001835-0s7ok4uw	5133	23	range	range	NN
cord-001835-0s7ok4uw	5133	24	of	of	IN
cord-001835-0s7ok4uw	5133	25	490	490	CD
cord-001835-0s7ok4uw	5133	26	-	-	SYM
cord-001835-0s7ok4uw	5133	27	680	680	CD
cord-001835-0s7ok4uw	5133	28	nm	nm	NN
cord-001835-0s7ok4uw	5133	29	.	.	.
cord-001835-0s7ok4uw	5134	1	In	in	IN
cord-001835-0s7ok4uw	5134	2	Gracilaria	Gracilaria	NNP
cord-001835-0s7ok4uw	5134	3	chilensis	chilensis	NN
cord-001835-0s7ok4uw	5134	4	,	,	,
cord-001835-0s7ok4uw	5134	5	an	an	DT
cord-001835-0s7ok4uw	5134	6	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	5134	7	red	red	JJ
cord-001835-0s7ok4uw	5134	8	algae	algae	NN
cord-001835-0s7ok4uw	5134	9	,	,	,
cord-001835-0s7ok4uw	5134	10	PBS	PBS	NNP
cord-001835-0s7ok4uw	5134	11	is	be	VBZ
cord-001835-0s7ok4uw	5134	12	composed	compose	VBN
cord-001835-0s7ok4uw	5134	13	of	of	IN
cord-001835-0s7ok4uw	5134	14	Phycoerythrin	Phycoerythrin	NNP
cord-001835-0s7ok4uw	5134	15	(	(	-LRB-
cord-001835-0s7ok4uw	5134	16	PE	PE	NNP
cord-001835-0s7ok4uw	5134	17	)	)	-RRB-
cord-001835-0s7ok4uw	5134	18	,	,	,
cord-001835-0s7ok4uw	5134	19	Phycocyanin	Phycocyanin	NNP
cord-001835-0s7ok4uw	5134	20	(	(	-LRB-
cord-001835-0s7ok4uw	5134	21	PC	PC	NNP
cord-001835-0s7ok4uw	5134	22	)	)	-RRB-
cord-001835-0s7ok4uw	5134	23	and	and	CC
cord-001835-0s7ok4uw	5134	24	Allophycocyanin	Allophycocyanin	NNP
cord-001835-0s7ok4uw	5134	25	(	(	-LRB-
cord-001835-0s7ok4uw	5134	26	APC	APC	NNP
cord-001835-0s7ok4uw	5134	27	)	)	-RRB-
cord-001835-0s7ok4uw	5134	28	;	;	:
cord-001835-0s7ok4uw	5134	29	these	these	DT
cord-001835-0s7ok4uw	5134	30	proteins	protein	NNS
cord-001835-0s7ok4uw	5134	31	possess	possess	VBP
cord-001835-0s7ok4uw	5134	32	chromophores	chromophore	NNS
cord-001835-0s7ok4uw	5134	33	which	which	WDT
cord-001835-0s7ok4uw	5134	34	capture	capture	VBP
cord-001835-0s7ok4uw	5134	35	energy	energy	NN
cord-001835-0s7ok4uw	5134	36	and	and	CC
cord-001835-0s7ok4uw	5134	37	then	then	RB
cord-001835-0s7ok4uw	5134	38	transfers	transfer	VBZ
cord-001835-0s7ok4uw	5134	39	it	-PRON-	PRP
cord-001835-0s7ok4uw	5134	40	to	to	IN
cord-001835-0s7ok4uw	5134	41	photosytems	photosytem	NNS
cord-001835-0s7ok4uw	5134	42	.	.	.
cord-001835-0s7ok4uw	5135	1	PBPs	pbp	NNS
cord-001835-0s7ok4uw	5135	2	are	be	VBP
cord-001835-0s7ok4uw	5135	3	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	5135	4	of	of	IN
cord-001835-0s7ok4uw	5135	5	a	a	DT
cord-001835-0s7ok4uw	5135	6	ab	ab	NN
cord-001835-0s7ok4uw	5135	7	heterodimer	heterodimer	NN
cord-001835-0s7ok4uw	5135	8	;	;	:
cord-001835-0s7ok4uw	5135	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	5135	10	oligomerizes	oligomerize	VBZ
cord-001835-0s7ok4uw	5135	11	into	into	IN
cord-001835-0s7ok4uw	5135	12	a	a	DT
cord-001835-0s7ok4uw	5135	13	trimer	trimer	NN
cord-001835-0s7ok4uw	5135	14	(	(	-LRB-
cord-001835-0s7ok4uw	5135	15	ab)3	ab)3	NNP
cord-001835-0s7ok4uw	5135	16	,	,	,
cord-001835-0s7ok4uw	5135	17	this	this	DT
cord-001835-0s7ok4uw	5135	18	trimer	trimer	NN
cord-001835-0s7ok4uw	5135	19	has	have	VBZ
cord-001835-0s7ok4uw	5135	20	discoidal	discoidal	JJ
cord-001835-0s7ok4uw	5135	21	shape	shape	NN
cord-001835-0s7ok4uw	5135	22	and	and	CC
cord-001835-0s7ok4uw	5135	23	it	-PRON-	PRP
cord-001835-0s7ok4uw	5135	24	is	be	VBZ
cord-001835-0s7ok4uw	5135	25	associated	associate	VBN
cord-001835-0s7ok4uw	5135	26	in	in	IN
cord-001835-0s7ok4uw	5135	27	hexamers	hexamer	NNS
cord-001835-0s7ok4uw	5135	28	(	(	-LRB-
cord-001835-0s7ok4uw	5135	29	ab)6	ab)6	RB
cord-001835-0s7ok4uw	5135	30	,	,	,
cord-001835-0s7ok4uw	5135	31	several	several	JJ
cord-001835-0s7ok4uw	5135	32	of	of	IN
cord-001835-0s7ok4uw	5135	33	this	this	DT
cord-001835-0s7ok4uw	5135	34	hexamers	hexamer	NNS
cord-001835-0s7ok4uw	5135	35	forms	form	VBZ
cord-001835-0s7ok4uw	5135	36	cylinder	cylinder	NN
cord-001835-0s7ok4uw	5135	37	-	-	HYPH
cord-001835-0s7ok4uw	5135	38	like	like	JJ
cord-001835-0s7ok4uw	5135	39	structures	structure	NNS
cord-001835-0s7ok4uw	5135	40	.	.	.
cord-001835-0s7ok4uw	5136	1	PBS	PBS	NNP
cord-001835-0s7ok4uw	5136	2	has	have	VBZ
cord-001835-0s7ok4uw	5136	3	2	2	CD
cord-001835-0s7ok4uw	5136	4	components	component	NNS
cord-001835-0s7ok4uw	5136	5	:	:	:
cord-001835-0s7ok4uw	5136	6	antennas	antenna	NNS
cord-001835-0s7ok4uw	5136	7	and	and	CC
cord-001835-0s7ok4uw	5136	8	core	core	NN
cord-001835-0s7ok4uw	5136	9	.	.	.
cord-001835-0s7ok4uw	5137	1	The	the	DT
cord-001835-0s7ok4uw	5137	2	antennas	antenna	NNS
cord-001835-0s7ok4uw	5137	3	are	be	VBP
cord-001835-0s7ok4uw	5137	4	composed	compose	VBN
cord-001835-0s7ok4uw	5137	5	of	of	IN
cord-001835-0s7ok4uw	5137	6	PE	PE	NNP
cord-001835-0s7ok4uw	5137	7	and	and	CC
cord-001835-0s7ok4uw	5137	8	PC	PC	NNP
cord-001835-0s7ok4uw	5137	9	,	,	,
cord-001835-0s7ok4uw	5137	10	whose	whose	WP$
cord-001835-0s7ok4uw	5137	11	function	function	NN
cord-001835-0s7ok4uw	5137	12	is	be	VBZ
cord-001835-0s7ok4uw	5137	13	to	to	TO
cord-001835-0s7ok4uw	5137	14	capture	capture	VB
cord-001835-0s7ok4uw	5137	15	energy	energy	NN
cord-001835-0s7ok4uw	5137	16	between	between	IN
cord-001835-0s7ok4uw	5137	17	490	490	CD
cord-001835-0s7ok4uw	5137	18	-	-	SYM
cord-001835-0s7ok4uw	5137	19	570	570	CD
cord-001835-0s7ok4uw	5137	20	and	and	CC
cord-001835-0s7ok4uw	5137	21	590	590	CD
cord-001835-0s7ok4uw	5137	22	-	-	SYM
cord-001835-0s7ok4uw	5137	23	625	625	CD
cord-001835-0s7ok4uw	5137	24	nm	nm	NN
cord-001835-0s7ok4uw	5137	25	respectively	respectively	RB
cord-001835-0s7ok4uw	5137	26	and	and	CC
cord-001835-0s7ok4uw	5137	27	transfer	transfer	VB
cord-001835-0s7ok4uw	5137	28	it	-PRON-	PRP
cord-001835-0s7ok4uw	5137	29	to	to	IN
cord-001835-0s7ok4uw	5137	30	the	the	DT
cord-001835-0s7ok4uw	5137	31	core	core	NN
cord-001835-0s7ok4uw	5137	32	.	.	.
cord-001835-0s7ok4uw	5138	1	The	the	DT
cord-001835-0s7ok4uw	5138	2	core	core	NN
cord-001835-0s7ok4uw	5138	3	is	be	VBZ
cord-001835-0s7ok4uw	5138	4	formed	form	VBN
cord-001835-0s7ok4uw	5138	5	by	by	IN
cord-001835-0s7ok4uw	5138	6	APC	APC	NNP
cord-001835-0s7ok4uw	5138	7	,	,	,
cord-001835-0s7ok4uw	5138	8	which	which	WDT
cord-001835-0s7ok4uw	5138	9	can	can	MD
cord-001835-0s7ok4uw	5138	10	absorb	absorb	VB
cord-001835-0s7ok4uw	5138	11	energy	energy	NN
cord-001835-0s7ok4uw	5138	12	in	in	IN
cord-001835-0s7ok4uw	5138	13	the	the	DT
cord-001835-0s7ok4uw	5138	14	620	620	CD
cord-001835-0s7ok4uw	5138	15	-	-	SYM
cord-001835-0s7ok4uw	5138	16	650	650	CD
cord-001835-0s7ok4uw	5138	17	nm	nm	NN
cord-001835-0s7ok4uw	5138	18	range	range	NN
cord-001835-0s7ok4uw	5138	19	.	.	.
cord-001835-0s7ok4uw	5139	1	APC	APC	NNP
cord-001835-0s7ok4uw	5139	2	emission	emission	NN
cord-001835-0s7ok4uw	5139	3	allows	allow	VBZ
cord-001835-0s7ok4uw	5139	4	transferring	transfer	VBG
cord-001835-0s7ok4uw	5139	5	energy	energy	NN
cord-001835-0s7ok4uw	5139	6	to	to	IN
cord-001835-0s7ok4uw	5139	7	the	the	DT
cord-001835-0s7ok4uw	5139	8	photosystems	photosystem	NNS
cord-001835-0s7ok4uw	5139	9	with	with	IN
cord-001835-0s7ok4uw	5139	10	high	high	JJ
cord-001835-0s7ok4uw	5139	11	efficiency	efficiency	NN
cord-001835-0s7ok4uw	5139	12	.	.	.
cord-001835-0s7ok4uw	5140	1	PBS	PBS	NNP
cord-001835-0s7ok4uw	5140	2	is	be	VBZ
cord-001835-0s7ok4uw	5140	3	also	also	RB
cord-001835-0s7ok4uw	5140	4	composed	compose	VBN
cord-001835-0s7ok4uw	5140	5	by	by	IN
cord-001835-0s7ok4uw	5140	6	linker	linker	NN
cord-001835-0s7ok4uw	5140	7	proteins	protein	NNS
cord-001835-0s7ok4uw	5140	8	which	which	WDT
cord-001835-0s7ok4uw	5140	9	allow	allow	VBP
cord-001835-0s7ok4uw	5140	10	the	the	DT
cord-001835-0s7ok4uw	5140	11	correct	correct	JJ
cord-001835-0s7ok4uw	5140	12	assembly	assembly	NN
cord-001835-0s7ok4uw	5140	13	of	of	IN
cord-001835-0s7ok4uw	5140	14	PBS	PBS	NNP
cord-001835-0s7ok4uw	5140	15	and	and	CC
cord-001835-0s7ok4uw	5140	16	possibly	possibly	RB
cord-001835-0s7ok4uw	5140	17	regulate	regulate	VB
cord-001835-0s7ok4uw	5140	18	the	the	DT
cord-001835-0s7ok4uw	5140	19	energy	energy	NN
cord-001835-0s7ok4uw	5140	20	transfer	transfer	NN
cord-001835-0s7ok4uw	5140	21	.	.	.
cord-001835-0s7ok4uw	5141	1	The	the	DT
cord-001835-0s7ok4uw	5141	2	main	main	JJ
cord-001835-0s7ok4uw	5141	3	goal	goal	NN
cord-001835-0s7ok4uw	5141	4	in	in	IN
cord-001835-0s7ok4uw	5141	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5141	6	group	group	NN
cord-001835-0s7ok4uw	5141	7	is	be	VBZ
cord-001835-0s7ok4uw	5141	8	to	to	TO
cord-001835-0s7ok4uw	5141	9	build	build	VB
cord-001835-0s7ok4uw	5141	10	an	an	DT
cord-001835-0s7ok4uw	5141	11	atomic	atomic	JJ
cord-001835-0s7ok4uw	5141	12	model	model	NN
cord-001835-0s7ok4uw	5141	13	of	of	IN
cord-001835-0s7ok4uw	5141	14	the	the	DT
cord-001835-0s7ok4uw	5141	15	Gracilaria	Gracilaria	NNP
cord-001835-0s7ok4uw	5141	16	chilensis	chilensis	NN
cord-001835-0s7ok4uw	5141	17	phycobilisome	phycobilisome	NN
cord-001835-0s7ok4uw	5141	18	.	.	.
cord-001835-0s7ok4uw	5142	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5142	2	have	have	VBP
cord-001835-0s7ok4uw	5142	3	solved	solve	VBN
cord-001835-0s7ok4uw	5142	4	the	the	DT
cord-001835-0s7ok4uw	5142	5	crystal	crystal	NN
cord-001835-0s7ok4uw	5142	6	structure	structure	NN
cord-001835-0s7ok4uw	5142	7	of	of	IN
cord-001835-0s7ok4uw	5142	8	PE	PE	NNP
cord-001835-0s7ok4uw	5142	9	and	and	CC
cord-001835-0s7ok4uw	5142	10	PC	PC	NNP
cord-001835-0s7ok4uw	5142	11	and	and	CC
cord-001835-0s7ok4uw	5142	12	created	create	VBD
cord-001835-0s7ok4uw	5142	13	an	an	DT
cord-001835-0s7ok4uw	5142	14	antenna	antenna	NN
cord-001835-0s7ok4uw	5142	15	model	model	NN
cord-001835-0s7ok4uw	5142	16	.	.	.
cord-001835-0s7ok4uw	5143	1	At	at	IN
cord-001835-0s7ok4uw	5143	2	present	present	JJ
cord-001835-0s7ok4uw	5143	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	5143	4	are	be	VBP
cord-001835-0s7ok4uw	5143	5	working	work	VBG
cord-001835-0s7ok4uw	5143	6	in	in	IN
cord-001835-0s7ok4uw	5143	7	APC	APC	NNP
cord-001835-0s7ok4uw	5143	8	and	and	CC
cord-001835-0s7ok4uw	5143	9	the	the	DT
cord-001835-0s7ok4uw	5143	10	chromophorilated	chromophorilated	JJ
cord-001835-0s7ok4uw	5143	11	linker	linker	NN
cord-001835-0s7ok4uw	5143	12	proteins	protein	NNS
cord-001835-0s7ok4uw	5143	13	.	.	.
cord-001835-0s7ok4uw	5144	1	The	the	DT
cord-001835-0s7ok4uw	5144	2	objective	objective	NN
cord-001835-0s7ok4uw	5144	3	of	of	IN
cord-001835-0s7ok4uw	5144	4	the	the	DT
cord-001835-0s7ok4uw	5144	5	present	present	JJ
cord-001835-0s7ok4uw	5144	6	work	work	NN
cord-001835-0s7ok4uw	5144	7	is	be	VBZ
cord-001835-0s7ok4uw	5144	8	to	to	TO
cord-001835-0s7ok4uw	5144	9	create	create	VB
cord-001835-0s7ok4uw	5144	10	a	a	DT
cord-001835-0s7ok4uw	5144	11	model	model	NN
cord-001835-0s7ok4uw	5144	12	of	of	IN
cord-001835-0s7ok4uw	5144	13	the	the	DT
cord-001835-0s7ok4uw	5144	14	core	core	NN
cord-001835-0s7ok4uw	5144	15	of	of	IN
cord-001835-0s7ok4uw	5144	16	Gracilaria	Gracilaria	NNP
cord-001835-0s7ok4uw	5144	17	chilensis	chilensis	NN
cord-001835-0s7ok4uw	5144	18	;	;	:
cord-001835-0s7ok4uw	5144	19	to	to	TO
cord-001835-0s7ok4uw	5144	20	achieve	achieve	VB
cord-001835-0s7ok4uw	5144	21	these	these	DT
cord-001835-0s7ok4uw	5144	22	we	-PRON-	PRP
cord-001835-0s7ok4uw	5144	23	have	have	VBP
cord-001835-0s7ok4uw	5144	24	used	use	VBN
cord-001835-0s7ok4uw	5144	25	molecular	molecular	JJ
cord-001835-0s7ok4uw	5144	26	biology	biology	NN
cord-001835-0s7ok4uw	5144	27	,	,	,
cord-001835-0s7ok4uw	5144	28	biochemistry	biochemistry	NN
cord-001835-0s7ok4uw	5144	29	and	and	CC
cord-001835-0s7ok4uw	5144	30	bioinformatics	bioinformatics	NN
cord-001835-0s7ok4uw	5144	31	techniques	technique	NNS
cord-001835-0s7ok4uw	5144	32	.	.	.
cord-001835-0s7ok4uw	5145	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5145	2	designed	design	VBD
cord-001835-0s7ok4uw	5145	3	oligonucleotides	oligonucleotide	NNS
cord-001835-0s7ok4uw	5145	4	primers	primer	NNS
cord-001835-0s7ok4uw	5145	5	for	for	IN
cord-001835-0s7ok4uw	5145	6	the	the	DT
cord-001835-0s7ok4uw	5145	7	four	four	CD
cord-001835-0s7ok4uw	5145	8	allophycocyanin	allophycocyanin	NNP
cord-001835-0s7ok4uw	5145	9	subunits	subunit	NNS
cord-001835-0s7ok4uw	5145	10	genes	gene	NNS
cord-001835-0s7ok4uw	5145	11	and	and	CC
cord-001835-0s7ok4uw	5145	12	for	for	IN
cord-001835-0s7ok4uw	5145	13	the	the	DT
cord-001835-0s7ok4uw	5145	14	globular	globular	JJ
cord-001835-0s7ok4uw	5145	15	domain	domain	NN
cord-001835-0s7ok4uw	5145	16	of	of	IN
cord-001835-0s7ok4uw	5145	17	the	the	DT
cord-001835-0s7ok4uw	5145	18	apcE	apcE	NNP
cord-001835-0s7ok4uw	5145	19	linker	linker	NN
cord-001835-0s7ok4uw	5145	20	.	.	.
cord-001835-0s7ok4uw	5146	1	These	these	DT
cord-001835-0s7ok4uw	5146	2	primers	primer	NNS
cord-001835-0s7ok4uw	5146	3	were	be	VBD
cord-001835-0s7ok4uw	5146	4	used	use	VBN
cord-001835-0s7ok4uw	5146	5	in	in	IN
cord-001835-0s7ok4uw	5146	6	PCR	PCR	NNP
cord-001835-0s7ok4uw	5146	7	experiments	experiment	NNS
cord-001835-0s7ok4uw	5146	8	to	to	TO
cord-001835-0s7ok4uw	5146	9	obtain	obtain	VB
cord-001835-0s7ok4uw	5146	10	the	the	DT
cord-001835-0s7ok4uw	5146	11	genes	gene	NNS
cord-001835-0s7ok4uw	5146	12	sequences	sequence	NNS
cord-001835-0s7ok4uw	5146	13	.	.	.
cord-001835-0s7ok4uw	5147	1	The	the	DT
cord-001835-0s7ok4uw	5147	2	sequences	sequence	NNS
cord-001835-0s7ok4uw	5147	3	were	be	VBD
cord-001835-0s7ok4uw	5147	4	translated	translate	VBN
cord-001835-0s7ok4uw	5147	5	to	to	IN
cord-001835-0s7ok4uw	5147	6	a	a	DT
cord-001835-0s7ok4uw	5147	7	aminoacid	aminoacid	JJ
cord-001835-0s7ok4uw	5147	8	sequences	sequence	NNS
cord-001835-0s7ok4uw	5147	9	and	and	CC
cord-001835-0s7ok4uw	5147	10	used	use	VBD
cord-001835-0s7ok4uw	5147	11	to	to	TO
cord-001835-0s7ok4uw	5147	12	build	build	VB
cord-001835-0s7ok4uw	5147	13	a	a	DT
cord-001835-0s7ok4uw	5147	14	3D	3d	JJ
cord-001835-0s7ok4uw	5147	15	model	model	NN
cord-001835-0s7ok4uw	5147	16	for	for	IN
cord-001835-0s7ok4uw	5147	17	APC	APC	NNP
cord-001835-0s7ok4uw	5147	18	subunits	subunit	NNS
cord-001835-0s7ok4uw	5147	19	and	and	CC
cord-001835-0s7ok4uw	5147	20	trimers	trimer	NNS
cord-001835-0s7ok4uw	5147	21	using	use	VBG
cord-001835-0s7ok4uw	5147	22	the	the	DT
cord-001835-0s7ok4uw	5147	23	software	software	NN
cord-001835-0s7ok4uw	5147	24	Modeller	Modeller	NNP
cord-001835-0s7ok4uw	5147	25	.	.	.
cord-001835-0s7ok4uw	5148	1	On	on	IN
cord-001835-0s7ok4uw	5148	2	the	the	DT
cord-001835-0s7ok4uw	5148	3	other	other	JJ
cord-001835-0s7ok4uw	5148	4	hand	hand	NN
cord-001835-0s7ok4uw	5148	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	5148	6	purified	purify	VBD
cord-001835-0s7ok4uw	5148	7	and	and	CC
cord-001835-0s7ok4uw	5148	8	analyzed	analyze	VBD
cord-001835-0s7ok4uw	5148	9	the	the	DT
cord-001835-0s7ok4uw	5148	10	spectroscopic	spectroscopic	JJ
cord-001835-0s7ok4uw	5148	11	properties	property	NNS
cord-001835-0s7ok4uw	5148	12	of	of	IN
cord-001835-0s7ok4uw	5148	13	APC	APC	NNP
cord-001835-0s7ok4uw	5148	14	from	from	IN
cord-001835-0s7ok4uw	5148	15	Gracilaria	Gracilaria	NNP
cord-001835-0s7ok4uw	5148	16	chilensis	chilensis	NN
cord-001835-0s7ok4uw	5148	17	using	use	VBG
cord-001835-0s7ok4uw	5148	18	absorption	absorption	NN
cord-001835-0s7ok4uw	5148	19	and	and	CC
cord-001835-0s7ok4uw	5148	20	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	5148	21	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	5148	22	.	.	.
cord-001835-0s7ok4uw	5149	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5149	2	also	also	RB
cord-001835-0s7ok4uw	5149	3	determined	determine	VBD
cord-001835-0s7ok4uw	5149	4	APC	APC	NNP
cord-001835-0s7ok4uw	5149	5	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	5149	6	state	state	NN
cord-001835-0s7ok4uw	5149	7	using	use	VBG
cord-001835-0s7ok4uw	5149	8	Gel	Gel	NNP
cord-001835-0s7ok4uw	5149	9	filtration	filtration	NN
cord-001835-0s7ok4uw	5149	10	.	.	.
cord-001835-0s7ok4uw	5150	1	Molecular	molecular	JJ
cord-001835-0s7ok4uw	5150	2	docking	docking	NN
cord-001835-0s7ok4uw	5150	3	using	use	VBG
cord-001835-0s7ok4uw	5150	4	the	the	DT
cord-001835-0s7ok4uw	5150	5	CLUSPRO	CLUSPRO	NNP
cord-001835-0s7ok4uw	5150	6	server	server	NN
cord-001835-0s7ok4uw	5150	7	was	be	VBD
cord-001835-0s7ok4uw	5150	8	performed	perform	VBN
cord-001835-0s7ok4uw	5150	9	to	to	TO
cord-001835-0s7ok4uw	5150	10	obtain	obtain	VB
cord-001835-0s7ok4uw	5150	11	a	a	DT
cord-001835-0s7ok4uw	5150	12	hexamer	hexamer	NN
cord-001835-0s7ok4uw	5150	13	and	and	CC
cord-001835-0s7ok4uw	5150	14	APC	APC	NNP
cord-001835-0s7ok4uw	5150	15	cylinder	cylinder	NN
cord-001835-0s7ok4uw	5150	16	models	model	NNS
cord-001835-0s7ok4uw	5150	17	.	.	.
cord-001835-0s7ok4uw	5151	1	Based	base	VBN
cord-001835-0s7ok4uw	5151	2	on	on	IN
cord-001835-0s7ok4uw	5151	3	electron	electron	NN
cord-001835-0s7ok4uw	5151	4	micrographs	micrograph	NNS
cord-001835-0s7ok4uw	5151	5	obtained	obtain	VBN
cord-001835-0s7ok4uw	5151	6	by	by	IN
cord-001835-0s7ok4uw	5151	7	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5151	8	lab	lab	NN
cord-001835-0s7ok4uw	5151	9	a	a	DT
cord-001835-0s7ok4uw	5151	10	tri	tri	JJ
cord-001835-0s7ok4uw	5151	11	-	-	JJ
cord-001835-0s7ok4uw	5151	12	cylindric	cylindric	JJ
cord-001835-0s7ok4uw	5151	13	core	core	NN
cord-001835-0s7ok4uw	5151	14	model	model	NN
cord-001835-0s7ok4uw	5151	15	was	be	VBD
cord-001835-0s7ok4uw	5151	16	built	build	VBN
cord-001835-0s7ok4uw	5151	17	.	.	.
cord-001835-0s7ok4uw	5152	1	All	all	PDT
cord-001835-0s7ok4uw	5152	2	the	the	DT
cord-001835-0s7ok4uw	5152	3	models	model	NNS
cord-001835-0s7ok4uw	5152	4	were	be	VBD
cord-001835-0s7ok4uw	5152	5	submitted	submit	VBN
cord-001835-0s7ok4uw	5152	6	to	to	IN
cord-001835-0s7ok4uw	5152	7	a	a	DT
cord-001835-0s7ok4uw	5152	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	5152	9	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	5152	10	using	use	VBG
cord-001835-0s7ok4uw	5152	11	GROMACS	GROMACS	NNP
cord-001835-0s7ok4uw	5152	12	software	software	NN
cord-001835-0s7ok4uw	5152	13	.	.	.
cord-001835-0s7ok4uw	5153	1	Finally	finally	RB
cord-001835-0s7ok4uw	5153	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	5153	3	determine	determine	VBP
cord-001835-0s7ok4uw	5153	4	possible	possible	JJ
cord-001835-0s7ok4uw	5153	5	energy	energy	NN
cord-001835-0s7ok4uw	5153	6	transfer	transfer	NN
cord-001835-0s7ok4uw	5153	7	pathways	pathway	NNS
cord-001835-0s7ok4uw	5153	8	in	in	IN
cord-001835-0s7ok4uw	5153	9	the	the	DT
cord-001835-0s7ok4uw	5153	10	core	core	NN
cord-001835-0s7ok4uw	5153	11	model	model	NN
cord-001835-0s7ok4uw	5153	12	applying	apply	VBG
cord-001835-0s7ok4uw	5153	13	the	the	DT
cord-001835-0s7ok4uw	5153	14	extended	extended	JJ
cord-001835-0s7ok4uw	5153	15	Forster	Forster	NNP
cord-001835-0s7ok4uw	5153	16	equation	equation	NN
cord-001835-0s7ok4uw	5153	17	,	,	,
cord-001835-0s7ok4uw	5153	18	spectroscopic	spectroscopic	JJ
cord-001835-0s7ok4uw	5153	19	data	datum	NNS
cord-001835-0s7ok4uw	5153	20	from	from	IN
cord-001835-0s7ok4uw	5153	21	literature	literature	NN
cord-001835-0s7ok4uw	5153	22	and	and	CC
cord-001835-0s7ok4uw	5153	23	the	the	DT
cord-001835-0s7ok4uw	5153	24	transition	transition	NN
cord-001835-0s7ok4uw	5153	25	dipole	dipole	NN
cord-001835-0s7ok4uw	5153	26	moments	moment	NNS
cord-001835-0s7ok4uw	5153	27	of	of	IN
cord-001835-0s7ok4uw	5153	28	each	each	DT
cord-001835-0s7ok4uw	5153	29	of	of	IN
cord-001835-0s7ok4uw	5153	30	the	the	DT
cord-001835-0s7ok4uw	5153	31	chromophores	chromophore	NNS
cord-001835-0s7ok4uw	5153	32	present	present	JJ
cord-001835-0s7ok4uw	5153	33	in	in	IN
cord-001835-0s7ok4uw	5153	34	the	the	DT
cord-001835-0s7ok4uw	5153	35	core	core	NN
cord-001835-0s7ok4uw	5153	36	.	.	.
cord-001835-0s7ok4uw	5154	1	As	as	IN
cord-001835-0s7ok4uw	5154	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	5154	3	of	of	IN
cord-001835-0s7ok4uw	5154	4	this	this	DT
cord-001835-0s7ok4uw	5154	5	work	work	NN
cord-001835-0s7ok4uw	5154	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	5154	7	built	build	VBD
cord-001835-0s7ok4uw	5154	8	the	the	DT
cord-001835-0s7ok4uw	5154	9	first	first	JJ
cord-001835-0s7ok4uw	5154	10	atomic	atomic	JJ
cord-001835-0s7ok4uw	5154	11	model	model	NN
cord-001835-0s7ok4uw	5154	12	of	of	IN
cord-001835-0s7ok4uw	5154	13	Gracilaria	Gracilaria	NNP
cord-001835-0s7ok4uw	5154	14	chilensis	chilensis	NN
cord-001835-0s7ok4uw	5154	15	phycobilisome	phycobilisome	NN
cord-001835-0s7ok4uw	5154	16	core	core	NN
cord-001835-0s7ok4uw	5154	17	and	and	CC
cord-001835-0s7ok4uw	5154	18	propose	propose	VB
cord-001835-0s7ok4uw	5154	19	energy	energy	NN
cord-001835-0s7ok4uw	5154	20	transfers	transfer	NNS
cord-001835-0s7ok4uw	5154	21	pathways	pathway	NNS
cord-001835-0s7ok4uw	5154	22	inside	inside	IN
cord-001835-0s7ok4uw	5154	23	the	the	DT
cord-001835-0s7ok4uw	5154	24	core	core	NN
cord-001835-0s7ok4uw	5154	25	in	in	IN
cord-001835-0s7ok4uw	5154	26	the	the	DT
cord-001835-0s7ok4uw	5154	27	context	context	NN
cord-001835-0s7ok4uw	5154	28	of	of	IN
cord-001835-0s7ok4uw	5154	29	a	a	DT
cord-001835-0s7ok4uw	5154	30	phycobilisome	phycobilisome	NN
cord-001835-0s7ok4uw	5154	31	.	.	.
cord-001835-0s7ok4uw	5155	1	Novel	novel	JJ
cord-001835-0s7ok4uw	5155	2	practical	practical	JJ
cord-001835-0s7ok4uw	5155	3	strategies	strategy	NNS
cord-001835-0s7ok4uw	5155	4	to	to	TO
cord-001835-0s7ok4uw	5155	5	access	access	VB
cord-001835-0s7ok4uw	5155	6	artificial	artificial	JJ
cord-001835-0s7ok4uw	5155	7	metalloenzymes	metalloenzyme	NNS
cord-001835-0s7ok4uw	5155	8	Marco	Marco	NNP
cord-001835-0s7ok4uw	5155	9	Filice	Filice	NNP
cord-001835-0s7ok4uw	5155	10	1	1	CD
cord-001835-0s7ok4uw	5155	11	,	,	,
cord-001835-0s7ok4uw	5156	1	Jose	Jose	NNP
cord-001835-0s7ok4uw	5156	2	Miguel	Miguel	NNP
cord-001835-0s7ok4uw	5156	3	Palomo	Palomo	NNP
cord-001835-0s7ok4uw	5156	4	1	1	CD
cord-001835-0s7ok4uw	5157	1	1	1	LS
cord-001835-0s7ok4uw	5157	2	Departamento	Departamento	NNP
cord-001835-0s7ok4uw	5157	3	de	de	NNP
cord-001835-0s7ok4uw	5157	4	Biocat	Biocat	NNP
cord-001835-0s7ok4uw	5157	5	alisis	alisis	NN
cord-001835-0s7ok4uw	5157	6	,	,	,
cord-001835-0s7ok4uw	5157	7	Instituto	Instituto	NNP
cord-001835-0s7ok4uw	5157	8	de	de	NNP
cord-001835-0s7ok4uw	5157	9	Cat	Cat	NNP
cord-001835-0s7ok4uw	5157	10	alisis	alisis	NN
cord-001835-0s7ok4uw	5157	11	,	,	,
cord-001835-0s7ok4uw	5157	12	CSIC	CSIC	NNP
cord-001835-0s7ok4uw	5157	13	Protein	Protein	NNP
cord-001835-0s7ok4uw	5157	14	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	5157	15	and	and	CC
cord-001835-0s7ok4uw	5157	16	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	5158	1	Since	since	IN
cord-001835-0s7ok4uw	5158	2	the	the	DT
cord-001835-0s7ok4uw	5158	3	first	first	JJ
cord-001835-0s7ok4uw	5158	4	report	report	NN
cord-001835-0s7ok4uw	5158	5	,	,	,
cord-001835-0s7ok4uw	5158	6	the	the	DT
cord-001835-0s7ok4uw	5158	7	design	design	NN
cord-001835-0s7ok4uw	5158	8	of	of	IN
cord-001835-0s7ok4uw	5158	9	artificial	artificial	JJ
cord-001835-0s7ok4uw	5158	10	metalloenzymes	metalloenzyme	NNS
cord-001835-0s7ok4uw	5158	11	has	have	VBZ
cord-001835-0s7ok4uw	5158	12	rapidly	rapidly	RB
cord-001835-0s7ok4uw	5158	13	been	be	VBN
cord-001835-0s7ok4uw	5158	14	converted	convert	VBN
cord-001835-0s7ok4uw	5158	15	into	into	IN
cord-001835-0s7ok4uw	5158	16	an	an	DT
cord-001835-0s7ok4uw	5158	17	important	important	JJ
cord-001835-0s7ok4uw	5158	18	topic	topic	NN
cord-001835-0s7ok4uw	5158	19	in	in	IN
cord-001835-0s7ok4uw	5158	20	biological	biological	JJ
cord-001835-0s7ok4uw	5158	21	and	and	CC
cord-001835-0s7ok4uw	5158	22	inorganic	inorganic	JJ
cord-001835-0s7ok4uw	5158	23	chemistry	chemistry	NN
cord-001835-0s7ok4uw	5158	24	due	due	IN
cord-001835-0s7ok4uw	5158	25	to	to	IN
cord-001835-0s7ok4uw	5158	26	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5158	27	potential	potential	JJ
cord-001835-0s7ok4uw	5158	28	applications	application	NNS
cord-001835-0s7ok4uw	5158	29	in	in	IN
cord-001835-0s7ok4uw	5158	30	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	5158	31	chemistry	chemistry	NN
cord-001835-0s7ok4uw	5158	32	,	,	,
cord-001835-0s7ok4uw	5158	33	nanoscience	nanoscience	NN
cord-001835-0s7ok4uw	5158	34	and	and	CC
cord-001835-0s7ok4uw	5158	35	biotechnology	biotechnology	NN
cord-001835-0s7ok4uw	5158	36	.	.	.
cord-001835-0s7ok4uw	5159	1	The	the	DT
cord-001835-0s7ok4uw	5159	2	combination	combination	NN
cord-001835-0s7ok4uw	5159	3	of	of	IN
cord-001835-0s7ok4uw	5159	4	a	a	DT
cord-001835-0s7ok4uw	5159	5	catalytically	catalytically	RB
cord-001835-0s7ok4uw	5159	6	active	active	JJ
cord-001835-0s7ok4uw	5159	7	organometallic	organometallic	NN
cord-001835-0s7ok4uw	5159	8	moiety	moiety	NN
cord-001835-0s7ok4uw	5159	9	with	with	IN
cord-001835-0s7ok4uw	5159	10	a	a	DT
cord-001835-0s7ok4uw	5159	11	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	5159	12	host	host	NN
cord-001835-0s7ok4uw	5159	13	has	have	VBZ
cord-001835-0s7ok4uw	5159	14	permitted	permit	VBN
cord-001835-0s7ok4uw	5159	15	the	the	DT
cord-001835-0s7ok4uw	5159	16	creation	creation	NN
cord-001835-0s7ok4uw	5159	17	of	of	IN
cord-001835-0s7ok4uw	5159	18	biohybrids	biohybrid	NNS
cord-001835-0s7ok4uw	5159	19	,	,	,
cord-001835-0s7ok4uw	5159	20	a	a	DT
cord-001835-0s7ok4uw	5159	21	new	new	JJ
cord-001835-0s7ok4uw	5159	22	kind	kind	NN
cord-001835-0s7ok4uw	5159	23	of	of	IN
cord-001835-0s7ok4uw	5159	24	heterogeneous	heterogeneous	JJ
cord-001835-0s7ok4uw	5159	25	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5159	26	entities	entity	NNS
cord-001835-0s7ok4uw	5159	27	combining	combine	VBG
cord-001835-0s7ok4uw	5159	28	the	the	DT
cord-001835-0s7ok4uw	5159	29	attractive	attractive	JJ
cord-001835-0s7ok4uw	5159	30	features	feature	NNS
cord-001835-0s7ok4uw	5159	31	of	of	IN
cord-001835-0s7ok4uw	5159	32	both	both	CC
cord-001835-0s7ok4uw	5159	33	homogeneous	homogeneous	JJ
cord-001835-0s7ok4uw	5159	34	and	and	CC
cord-001835-0s7ok4uw	5159	35	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5159	36	systems	system	NNS
cord-001835-0s7ok4uw	5159	37	.	.	.
cord-001835-0s7ok4uw	5160	1	Presenting	present	VBG
cord-001835-0s7ok4uw	5160	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5160	3	most	most	RBS
cord-001835-0s7ok4uw	5160	4	recent	recent	JJ
cord-001835-0s7ok4uw	5160	5	achievements	achievement	NNS
cord-001835-0s7ok4uw	5160	6	in	in	IN
cord-001835-0s7ok4uw	5160	7	this	this	DT
cord-001835-0s7ok4uw	5160	8	research	research	NN
cord-001835-0s7ok4uw	5160	9	area	area	NN
cord-001835-0s7ok4uw	5160	10	,	,	,
cord-001835-0s7ok4uw	5160	11	here	here	RB
cord-001835-0s7ok4uw	5160	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	5160	13	describe	describe	VBP
cord-001835-0s7ok4uw	5160	14	two	two	CD
cord-001835-0s7ok4uw	5160	15	novel	novel	NN
cord-001835-0s7ok4uw	5160	16	powerful	powerful	JJ
cord-001835-0s7ok4uw	5160	17	and	and	CC
cord-001835-0s7ok4uw	5160	18	promising	promising	JJ
cord-001835-0s7ok4uw	5160	19	approaches	approach	NNS
cord-001835-0s7ok4uw	5160	20	focusing	focus	VBG
cord-001835-0s7ok4uw	5160	21	the	the	DT
cord-001835-0s7ok4uw	5160	22	practical	practical	JJ
cord-001835-0s7ok4uw	5160	23	synthesis	synthesis	NN
cord-001835-0s7ok4uw	5160	24	and	and	CC
cord-001835-0s7ok4uw	5160	25	large	large	JJ
cord-001835-0s7ok4uw	5160	26	scale	scale	NN
cord-001835-0s7ok4uw	5160	27	production	production	NN
cord-001835-0s7ok4uw	5160	28	of	of	IN
cord-001835-0s7ok4uw	5160	29	heterogeneous	heterogeneous	JJ
cord-001835-0s7ok4uw	5160	30	artificial	artificial	JJ
cord-001835-0s7ok4uw	5160	31	metalloenzymes	metalloenzyme	NNS
cord-001835-0s7ok4uw	5160	32	showing	show	VBG
cord-001835-0s7ok4uw	5160	33	chimeric	chimeric	JJ
cord-001835-0s7ok4uw	5160	34	activity	activity	NN
cord-001835-0s7ok4uw	5160	35	.	.	.
cord-001835-0s7ok4uw	5161	1	The	the	DT
cord-001835-0s7ok4uw	5161	2	first	first	JJ
cord-001835-0s7ok4uw	5161	3	strategy	strategy	NN
cord-001835-0s7ok4uw	5161	4	is	be	VBZ
cord-001835-0s7ok4uw	5161	5	based	base	VBN
cord-001835-0s7ok4uw	5161	6	on	on	IN
cord-001835-0s7ok4uw	5161	7	the	the	DT
cord-001835-0s7ok4uw	5161	8	in	in	IN
cord-001835-0s7ok4uw	5161	9	situ	situ	JJ
cord-001835-0s7ok4uw	5161	10	synthesis	synthesis	NN
cord-001835-0s7ok4uw	5161	11	of	of	IN
cord-001835-0s7ok4uw	5161	12	noble	noble	JJ
cord-001835-0s7ok4uw	5161	13	metal	metal	NN
cord-001835-0s7ok4uw	5161	14	nanoparticles	nanoparticle	NNS
cord-001835-0s7ok4uw	5161	15	and	and	CC
cord-001835-0s7ok4uw	5161	16	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5161	17	supramolecular	supramolecular	JJ
cord-001835-0s7ok4uw	5161	18	assembly	assembly	NN
cord-001835-0s7ok4uw	5161	19	with	with	IN
cord-001835-0s7ok4uw	5161	20	a	a	DT
cord-001835-0s7ok4uw	5161	21	microbial	microbial	JJ
cord-001835-0s7ok4uw	5161	22	lipase	lipase	NN
cord-001835-0s7ok4uw	5161	23	from	from	IN
cord-001835-0s7ok4uw	5161	24	Candida	Candida	NNP
cord-001835-0s7ok4uw	5161	25	antarctica	antarctica	NNP
cord-001835-0s7ok4uw	5161	26	(	(	-LRB-
cord-001835-0s7ok4uw	5161	27	fraction	fraction	NN
cord-001835-0s7ok4uw	5161	28	B	B	NNP
cord-001835-0s7ok4uw	5161	29	)	)	-RRB-
cord-001835-0s7ok4uw	5161	30	finally	finally	RB
cord-001835-0s7ok4uw	5161	31	creating	create	VBG
cord-001835-0s7ok4uw	5161	32	an	an	DT
cord-001835-0s7ok4uw	5161	33	ultra	ultra	JJ
cord-001835-0s7ok4uw	5161	34	-	-	JJ
cord-001835-0s7ok4uw	5161	35	active	active	JJ
cord-001835-0s7ok4uw	5161	36	organometallic	organometallic	JJ
cord-001835-0s7ok4uw	5161	37	-	-	HYPH
cord-001835-0s7ok4uw	5161	38	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5161	39	heterogeneous	heterogeneous	JJ
cord-001835-0s7ok4uw	5161	40	nanobiohybrid	nanobiohybrid	NN
cord-001835-0s7ok4uw	5161	41	.	.	.
cord-001835-0s7ok4uw	5162	1	In	in	IN
cord-001835-0s7ok4uw	5162	2	the	the	DT
cord-001835-0s7ok4uw	5162	3	second	second	JJ
cord-001835-0s7ok4uw	5162	4	approach	approach	NN
cord-001835-0s7ok4uw	5162	5	,	,	,
cord-001835-0s7ok4uw	5162	6	combining	combine	VBG
cord-001835-0s7ok4uw	5162	7	different	different	JJ
cord-001835-0s7ok4uw	5162	8	protein	protein	NN
cord-001835-0s7ok4uw	5162	9	engineering	engineering	NN
cord-001835-0s7ok4uw	5162	10	protocols	protocol	NNS
cord-001835-0s7ok4uw	5162	11	(	(	-LRB-
cord-001835-0s7ok4uw	5162	12	molecular	molecular	JJ
cord-001835-0s7ok4uw	5162	13	biology	biology	NN
cord-001835-0s7ok4uw	5162	14	,	,	,
cord-001835-0s7ok4uw	5162	15	orienting	orient	VBG
cord-001835-0s7ok4uw	5162	16	immobilization	immobilization	NN
cord-001835-0s7ok4uw	5162	17	,	,	,
cord-001835-0s7ok4uw	5162	18	solid	solid	JJ
cord-001835-0s7ok4uw	5162	19	-	-	HYPH
cord-001835-0s7ok4uw	5162	20	phase	phase	NN
cord-001835-0s7ok4uw	5162	21	bioorganic	bioorganic	JJ
cord-001835-0s7ok4uw	5162	22	modification	modification	NN
cord-001835-0s7ok4uw	5162	23	and	and	CC
cord-001835-0s7ok4uw	5162	24	bioinformatic	bioinformatic	JJ
cord-001835-0s7ok4uw	5162	25	tools	tool	NNS
cord-001835-0s7ok4uw	5162	26	)	)	-RRB-
cord-001835-0s7ok4uw	5162	27	,	,	,
cord-001835-0s7ok4uw	5162	28	an	an	DT
cord-001835-0s7ok4uw	5162	29	orthogonal	orthogonal	JJ
cord-001835-0s7ok4uw	5162	30	solid	solid	JJ
cord-001835-0s7ok4uw	5162	31	-	-	HYPH
cord-001835-0s7ok4uw	5162	32	phase	phase	NN
cord-001835-0s7ok4uw	5162	33	strategy	strategy	NN
cord-001835-0s7ok4uw	5162	34	creating	create	VBG
cord-001835-0s7ok4uw	5162	35	novel	novel	JJ
cord-001835-0s7ok4uw	5162	36	unnatural	unnatural	JJ
cord-001835-0s7ok4uw	5162	37	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5162	38	sites	site	NNS
cord-001835-0s7ok4uw	5162	39	was	be	VBD
cord-001835-0s7ok4uw	5162	40	designed	design	VBN
cord-001835-0s7ok4uw	5162	41	and	and	CC
cord-001835-0s7ok4uw	5162	42	optimized	optimize	VBN
cord-001835-0s7ok4uw	5162	43	.	.	.
cord-001835-0s7ok4uw	5163	1	The	the	DT
cord-001835-0s7ok4uw	5163	2	application	application	NN
cord-001835-0s7ok4uw	5163	3	of	of	IN
cord-001835-0s7ok4uw	5163	4	such	such	PDT
cord-001835-0s7ok4uw	5163	5	a	a	DT
cord-001835-0s7ok4uw	5163	6	strategy	strategy	NN
cord-001835-0s7ok4uw	5163	7	onto	onto	IN
cord-001835-0s7ok4uw	5163	8	the	the	DT
cord-001835-0s7ok4uw	5163	9	structure	structure	NN
cord-001835-0s7ok4uw	5163	10	of	of	IN
cord-001835-0s7ok4uw	5163	11	the	the	DT
cord-001835-0s7ok4uw	5163	12	lipase	lipase	NN
cord-001835-0s7ok4uw	5163	13	from	from	IN
cord-001835-0s7ok4uw	5163	14	Geobacillus	Geobacillus	NNP
cord-001835-0s7ok4uw	5163	15	thermocatelunatus	thermocatelunatus	NN
cord-001835-0s7ok4uw	5163	16	permitted	permit	VBD
cord-001835-0s7ok4uw	5163	17	the	the	DT
cord-001835-0s7ok4uw	5163	18	generation	generation	NN
cord-001835-0s7ok4uw	5163	19	of	of	IN
cord-001835-0s7ok4uw	5163	20	a	a	DT
cord-001835-0s7ok4uw	5163	21	heterogeneous	heterogeneous	JJ
cord-001835-0s7ok4uw	5163	22	artificial	artificial	JJ
cord-001835-0s7ok4uw	5163	23	metallolipase	metallolipase	NN
cord-001835-0s7ok4uw	5163	24	with	with	IN
cord-001835-0s7ok4uw	5163	25	chimeric	chimeric	JJ
cord-001835-0s7ok4uw	5163	26	activity	activity	NN
cord-001835-0s7ok4uw	5163	27	.	.	.
cord-001835-0s7ok4uw	5164	1	As	as	IN
cord-001835-0s7ok4uw	5164	2	proof	proof	NN
cord-001835-0s7ok4uw	5164	3	-	-	HYPH
cord-001835-0s7ok4uw	5164	4	of	of	IN
cord-001835-0s7ok4uw	5164	5	-	-	HYPH
cord-001835-0s7ok4uw	5164	6	concept	concept	NN
cord-001835-0s7ok4uw	5164	7	,	,	,
cord-001835-0s7ok4uw	5164	8	the	the	DT
cord-001835-0s7ok4uw	5164	9	combinatorial	combinatorial	JJ
cord-001835-0s7ok4uw	5164	10	library	library	NN
cord-001835-0s7ok4uw	5164	11	of	of	IN
cord-001835-0s7ok4uw	5164	12	generated	generate	VBN
cord-001835-0s7ok4uw	5164	13	artificial	artificial	JJ
cord-001835-0s7ok4uw	5164	14	metalloenzymes	metalloenzyme	NNS
cord-001835-0s7ok4uw	5164	15	obtained	obtain	VBN
cord-001835-0s7ok4uw	5164	16	by	by	IN
cord-001835-0s7ok4uw	5164	17	both	both	DT
cord-001835-0s7ok4uw	5164	18	strategies	strategy	NNS
cord-001835-0s7ok4uw	5164	19	was	be	VBD
cord-001835-0s7ok4uw	5164	20	successfully	successfully	RB
cord-001835-0s7ok4uw	5164	21	assessed	assess	VBN
cord-001835-0s7ok4uw	5164	22	in	in	IN
cord-001835-0s7ok4uw	5164	23	a	a	DT
cord-001835-0s7ok4uw	5164	24	set	set	NN
cord-001835-0s7ok4uw	5164	25	of	of	IN
cord-001835-0s7ok4uw	5164	26	different	different	JJ
cord-001835-0s7ok4uw	5164	27	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	5164	28	reactions	reaction	NNS
cord-001835-0s7ok4uw	5164	29	(	(	-LRB-
cord-001835-0s7ok4uw	5164	30	selective	selective	JJ
cord-001835-0s7ok4uw	5164	31	C	c	NN
cord-001835-0s7ok4uw	5164	32	-	-	HYPH
cord-001835-0s7ok4uw	5164	33	C	c	NN
cord-001835-0s7ok4uw	5164	34	bond	bond	NN
cord-001835-0s7ok4uw	5164	35	formation	formation	NN
cord-001835-0s7ok4uw	5164	36	as	as	IN
cord-001835-0s7ok4uw	5164	37	Suzuki	Suzuki	NNP
cord-001835-0s7ok4uw	5164	38	,	,	,
cord-001835-0s7ok4uw	5164	39	Heck	Heck	NNP
cord-001835-0s7ok4uw	5164	40	or	or	CC
cord-001835-0s7ok4uw	5164	41	Diels	Diels	NNP
cord-001835-0s7ok4uw	5164	42	-	-	HYPH
cord-001835-0s7ok4uw	5164	43	Alder	Alder	NNP
cord-001835-0s7ok4uw	5164	44	reactions	reaction	NNS
cord-001835-0s7ok4uw	5164	45	)	)	-RRB-
cord-001835-0s7ok4uw	5164	46	and	and	CC
cord-001835-0s7ok4uw	5164	47	also	also	RB
cord-001835-0s7ok4uw	5164	48	combining	combine	VBG
cord-001835-0s7ok4uw	5164	49	both	both	DT
cord-001835-0s7ok4uw	5164	50	activities	activity	NNS
cord-001835-0s7ok4uw	5164	51	(	(	-LRB-
cord-001835-0s7ok4uw	5164	52	metallic	metallic	JJ
cord-001835-0s7ok4uw	5164	53	and	and	CC
cord-001835-0s7ok4uw	5164	54	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5164	55	)	)	-RRB-
cord-001835-0s7ok4uw	5164	56	in	in	IN
cord-001835-0s7ok4uw	5164	57	cascade	cascade	NN
cord-001835-0s7ok4uw	5164	58	processes	process	NNS
cord-001835-0s7ok4uw	5164	59	such	such	JJ
cord-001835-0s7ok4uw	5164	60	as	as	IN
cord-001835-0s7ok4uw	5164	61	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	5164	62	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	5164	63	resolution	resolution	NN
cord-001835-0s7ok4uw	5164	64	of	of	IN
cord-001835-0s7ok4uw	5164	65	amines	amine	NNS
cord-001835-0s7ok4uw	5164	66	or	or	CC
cord-001835-0s7ok4uw	5164	67	production	production	NN
cord-001835-0s7ok4uw	5164	68	of	of	IN
cord-001835-0s7ok4uw	5164	69	arylamines	arylamine	NNS
cord-001835-0s7ok4uw	5164	70	.	.	.
cord-001835-0s7ok4uw	5165	1	The	the	DT
cord-001835-0s7ok4uw	5165	2	obtained	obtain	VBN
cord-001835-0s7ok4uw	5165	3	results	result	NNS
cord-001835-0s7ok4uw	5165	4	were	be	VBD
cord-001835-0s7ok4uw	5165	5	excellent	excellent	JJ
cord-001835-0s7ok4uw	5165	6	in	in	IN
cord-001835-0s7ok4uw	5165	7	all	all	DT
cord-001835-0s7ok4uw	5165	8	cases	case	NNS
cord-001835-0s7ok4uw	5165	9	.	.	.
cord-001835-0s7ok4uw	5166	1	Extending	extend	VBG
cord-001835-0s7ok4uw	5166	2	this	this	DT
cord-001835-0s7ok4uw	5166	3	strategy	strategy	NN
cord-001835-0s7ok4uw	5166	4	to	to	IN
cord-001835-0s7ok4uw	5166	5	other	other	JJ
cord-001835-0s7ok4uw	5166	6	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5166	7	,	,	,
cord-001835-0s7ok4uw	5166	8	proteins	protein	NNS
cord-001835-0s7ok4uw	5166	9	and	and	CC
cord-001835-0s7ok4uw	5166	10	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5166	11	metals	metal	NNS
cord-001835-0s7ok4uw	5166	12	,	,	,
cord-001835-0s7ok4uw	5166	13	we	-PRON-	PRP
cord-001835-0s7ok4uw	5166	14	envisage	envisage	VBP
cord-001835-0s7ok4uw	5166	15	the	the	DT
cord-001835-0s7ok4uw	5166	16	creation	creation	NN
cord-001835-0s7ok4uw	5166	17	of	of	IN
cord-001835-0s7ok4uw	5166	18	a	a	DT
cord-001835-0s7ok4uw	5166	19	combinatorial	combinatorial	JJ
cord-001835-0s7ok4uw	5166	20	library	library	NN
cord-001835-0s7ok4uw	5166	21	of	of	IN
cord-001835-0s7ok4uw	5166	22	programmable	programmable	JJ
cord-001835-0s7ok4uw	5166	23	artificial	artificial	JJ
cord-001835-0s7ok4uw	5166	24	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5166	25	useful	useful	JJ
cord-001835-0s7ok4uw	5166	26	for	for	IN
cord-001835-0s7ok4uw	5166	27	a	a	DT
cord-001835-0s7ok4uw	5166	28	wide	wide	JJ
cord-001835-0s7ok4uw	5166	29	set	set	NN
cord-001835-0s7ok4uw	5166	30	of	of	IN
cord-001835-0s7ok4uw	5166	31	applications	application	NNS
cord-001835-0s7ok4uw	5166	32	(	(	-LRB-
cord-001835-0s7ok4uw	5166	33	i.e.	i.e.	FW
cord-001835-0s7ok4uw	5166	34	fine	fine	JJ
cord-001835-0s7ok4uw	5166	35	organic	organic	JJ
cord-001835-0s7ok4uw	5166	36	and	and	CC
cord-001835-0s7ok4uw	5166	37	medicinal	medicinal	JJ
cord-001835-0s7ok4uw	5166	38	chemistry	chemistry	NN
cord-001835-0s7ok4uw	5166	39	,	,	,
cord-001835-0s7ok4uw	5166	40	bioremediation	bioremediation	NN
cord-001835-0s7ok4uw	5166	41	or	or	CC
cord-001835-0s7ok4uw	5166	42	biomedicine	biomedicine	NN
cord-001835-0s7ok4uw	5166	43	)	)	-RRB-
cord-001835-0s7ok4uw	5166	44	.	.	.
cord-001835-0s7ok4uw	5167	1	Proteomic	proteomic	JJ
cord-001835-0s7ok4uw	5167	2	examination	examination	NN
cord-001835-0s7ok4uw	5167	3	of	of	IN
cord-001835-0s7ok4uw	5167	4	the	the	DT
cord-001835-0s7ok4uw	5167	5	yeast	yeast	NN
cord-001835-0s7ok4uw	5167	6	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	5167	7	pore	pore	NN
cord-001835-0s7ok4uw	5167	8	complex	complex	JJ
cord-001835-0s7ok4uw	5167	9	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	5167	10	 	 	_SP
cord-001835-0s7ok4uw	5167	11	Protein	Protein	NNP
cord-001835-0s7ok4uw	5167	12	turnover	turnover	NN
cord-001835-0s7ok4uw	5167	13	and	and	CC
cord-001835-0s7ok4uw	5167	14	exchange	exchange	NN
cord-001835-0s7ok4uw	5167	15	Nuclear	nuclear	JJ
cord-001835-0s7ok4uw	5167	16	pore	pore	NN
cord-001835-0s7ok4uw	5167	17	complexes	complex	NNS
cord-001835-0s7ok4uw	5167	18	(	(	-LRB-
cord-001835-0s7ok4uw	5167	19	NPCs	npc	NNS
cord-001835-0s7ok4uw	5167	20	)	)	-RRB-
cord-001835-0s7ok4uw	5167	21	are	be	VBP
cord-001835-0s7ok4uw	5167	22	proteinaceous	proteinaceous	JJ
cord-001835-0s7ok4uw	5167	23	assemblies	assembly	NNS
cord-001835-0s7ok4uw	5167	24	situated	situate	VBN
cord-001835-0s7ok4uw	5167	25	in	in	IN
cord-001835-0s7ok4uw	5167	26	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	5167	27	envelopes	envelope	NNS
cord-001835-0s7ok4uw	5167	28	of	of	IN
cord-001835-0s7ok4uw	5167	29	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	5167	30	cells	cell	NNS
cord-001835-0s7ok4uw	5167	31	.	.	.
cord-001835-0s7ok4uw	5168	1	The	the	DT
cord-001835-0s7ok4uw	5168	2	main	main	JJ
cord-001835-0s7ok4uw	5168	3	function	function	NN
cord-001835-0s7ok4uw	5168	4	of	of	IN
cord-001835-0s7ok4uw	5168	5	the	the	DT
cord-001835-0s7ok4uw	5168	6	NPC	NPC	NNP
cord-001835-0s7ok4uw	5168	7	is	be	VBZ
cord-001835-0s7ok4uw	5168	8	the	the	DT
cord-001835-0s7ok4uw	5168	9	selective	selective	JJ
cord-001835-0s7ok4uw	5168	10	transport	transport	NN
cord-001835-0s7ok4uw	5168	11	of	of	IN
cord-001835-0s7ok4uw	5168	12	macromolecules	macromolecule	NNS
cord-001835-0s7ok4uw	5168	13	.	.	.
cord-001835-0s7ok4uw	5169	1	NPCs	npc	NNS
cord-001835-0s7ok4uw	5169	2	also	also	RB
cord-001835-0s7ok4uw	5169	3	partake	partake	VBP
cord-001835-0s7ok4uw	5169	4	in	in	IN
cord-001835-0s7ok4uw	5169	5	other	other	JJ
cord-001835-0s7ok4uw	5169	6	functions	function	NNS
cord-001835-0s7ok4uw	5169	7	,	,	,
cord-001835-0s7ok4uw	5169	8	such	such	JJ
cord-001835-0s7ok4uw	5169	9	as	as	IN
cord-001835-0s7ok4uw	5169	10	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	5169	11	organization	organization	NN
cord-001835-0s7ok4uw	5169	12	and	and	CC
cord-001835-0s7ok4uw	5169	13	gene	gene	NN
cord-001835-0s7ok4uw	5169	14	regulation	regulation	NN
cord-001835-0s7ok4uw	5169	15	.	.	.
cord-001835-0s7ok4uw	5170	1	The	the	DT
cord-001835-0s7ok4uw	5170	2	core	core	NN
cord-001835-0s7ok4uw	5170	3	scaffold	scaffold	NN
cord-001835-0s7ok4uw	5170	4	of	of	IN
cord-001835-0s7ok4uw	5170	5	the	the	DT
cord-001835-0s7ok4uw	5170	6	NPC	NPC	NNP
cord-001835-0s7ok4uw	5170	7	is	be	VBZ
cord-001835-0s7ok4uw	5170	8	thought	think	VBN
cord-001835-0s7ok4uw	5170	9	to	to	TO
cord-001835-0s7ok4uw	5170	10	be	be	VB
cord-001835-0s7ok4uw	5170	11	a	a	DT
cord-001835-0s7ok4uw	5170	12	stable	stable	JJ
cord-001835-0s7ok4uw	5170	13	structure	structure	NN
cord-001835-0s7ok4uw	5170	14	,	,	,
cord-001835-0s7ok4uw	5170	15	while	while	IN
cord-001835-0s7ok4uw	5170	16	the	the	DT
cord-001835-0s7ok4uw	5170	17	peripheral	peripheral	JJ
cord-001835-0s7ok4uw	5170	18	components	component	NNS
cord-001835-0s7ok4uw	5170	19	exchange	exchange	NN
cord-001835-0s7ok4uw	5170	20	at	at	IN
cord-001835-0s7ok4uw	5170	21	various	various	JJ
cord-001835-0s7ok4uw	5170	22	rates	rate	NNS
cord-001835-0s7ok4uw	5170	23	.	.	.
cord-001835-0s7ok4uw	5171	1	However	however	RB
cord-001835-0s7ok4uw	5171	2	,	,	,
cord-001835-0s7ok4uw	5171	3	these	these	DT
cord-001835-0s7ok4uw	5171	4	phenomena	phenomenon	NNS
cord-001835-0s7ok4uw	5171	5	have	have	VBP
cord-001835-0s7ok4uw	5171	6	not	not	RB
cord-001835-0s7ok4uw	5171	7	been	be	VBN
cord-001835-0s7ok4uw	5171	8	elucidated	elucidate	VBN
cord-001835-0s7ok4uw	5171	9	in	in	IN
cord-001835-0s7ok4uw	5171	10	detail	detail	NN
cord-001835-0s7ok4uw	5171	11	.	.	.
cord-001835-0s7ok4uw	5172	1	The	the	DT
cord-001835-0s7ok4uw	5172	2	recent	recent	JJ
cord-001835-0s7ok4uw	5172	3	findings	finding	NNS
cord-001835-0s7ok4uw	5172	4	that	that	WDT
cord-001835-0s7ok4uw	5172	5	yeast	yeast	NN
cord-001835-0s7ok4uw	5172	6	daughter	daughter	NN
cord-001835-0s7ok4uw	5172	7	cells	cell	NNS
cord-001835-0s7ok4uw	5172	8	get	get	VBP
cord-001835-0s7ok4uw	5172	9	a	a	DT
cord-001835-0s7ok4uw	5172	10	higher	high	JJR
cord-001835-0s7ok4uw	5172	11	proportion	proportion	NN
cord-001835-0s7ok4uw	5172	12	of	of	IN
cord-001835-0s7ok4uw	5172	13	the	the	DT
cord-001835-0s7ok4uw	5172	14	old	old	JJ
cord-001835-0s7ok4uw	5172	15	NPCs	npc	NNS
cord-001835-0s7ok4uw	5172	16	and	and	CC
cord-001835-0s7ok4uw	5172	17	the	the	DT
cord-001835-0s7ok4uw	5172	18	core	core	NN
cord-001835-0s7ok4uw	5172	19	scaffold	scaffold	NN
cord-001835-0s7ok4uw	5172	20	hardly	hardly	RB
cord-001835-0s7ok4uw	5172	21	turns	turn	VBZ
cord-001835-0s7ok4uw	5172	22	over	over	RP
cord-001835-0s7ok4uw	5172	23	raise	raise	VBP
cord-001835-0s7ok4uw	5172	24	the	the	DT
cord-001835-0s7ok4uw	5172	25	possibility	possibility	NN
cord-001835-0s7ok4uw	5172	26	that	that	IN
cord-001835-0s7ok4uw	5172	27	the	the	DT
cord-001835-0s7ok4uw	5172	28	exchange	exchange	NN
cord-001835-0s7ok4uw	5172	29	of	of	IN
cord-001835-0s7ok4uw	5172	30	the	the	DT
cord-001835-0s7ok4uw	5172	31	peripheral	peripheral	JJ
cord-001835-0s7ok4uw	5172	32	nucleoporins	nucleoporin	NNS
cord-001835-0s7ok4uw	5172	33	can	can	MD
cord-001835-0s7ok4uw	5172	34	be	be	VB
cord-001835-0s7ok4uw	5172	35	a	a	DT
cord-001835-0s7ok4uw	5172	36	repair	repair	NN
cord-001835-0s7ok4uw	5172	37	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5172	38	.	.	.
cord-001835-0s7ok4uw	5173	1	Yeast	yeast	NN
cord-001835-0s7ok4uw	5173	2	provides	provide	VBZ
cord-001835-0s7ok4uw	5173	3	a	a	DT
cord-001835-0s7ok4uw	5173	4	useful	useful	JJ
cord-001835-0s7ok4uw	5173	5	organism	organism	NN
cord-001835-0s7ok4uw	5173	6	for	for	IN
cord-001835-0s7ok4uw	5173	7	the	the	DT
cord-001835-0s7ok4uw	5173	8	interrogation	interrogation	NN
cord-001835-0s7ok4uw	5173	9	of	of	IN
cord-001835-0s7ok4uw	5173	10	nucleoporin	nucleoporin	NNP
cord-001835-0s7ok4uw	5173	11	exchange	exchange	NNP
cord-001835-0s7ok4uw	5173	12	,	,	,
cord-001835-0s7ok4uw	5173	13	as	as	IN
cord-001835-0s7ok4uw	5173	14	it	-PRON-	PRP
cord-001835-0s7ok4uw	5173	15	performs	perform	VBZ
cord-001835-0s7ok4uw	5173	16	closed	closed	JJ
cord-001835-0s7ok4uw	5173	17	mitosis	mitosis	NN
cord-001835-0s7ok4uw	5173	18	;	;	:
cord-001835-0s7ok4uw	5173	19	hence	hence	RB
cord-001835-0s7ok4uw	5173	20	the	the	DT
cord-001835-0s7ok4uw	5173	21	only	only	JJ
cord-001835-0s7ok4uw	5173	22	mixing	mixing	NN
cord-001835-0s7ok4uw	5173	23	of	of	IN
cord-001835-0s7ok4uw	5173	24	NPC	NPC	NNP
cord-001835-0s7ok4uw	5173	25	constituents	constituent	NNS
cord-001835-0s7ok4uw	5173	26	is	be	VBZ
cord-001835-0s7ok4uw	5173	27	due	due	JJ
cord-001835-0s7ok4uw	5173	28	to	to	IN
cord-001835-0s7ok4uw	5173	29	exchange	exchange	VB
cord-001835-0s7ok4uw	5173	30	.	.	.
cord-001835-0s7ok4uw	5174	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5174	2	have	have	VBP
cord-001835-0s7ok4uw	5174	3	developed	develop	VBN
cord-001835-0s7ok4uw	5174	4	a	a	DT
cord-001835-0s7ok4uw	5174	5	panel	panel	NN
cord-001835-0s7ok4uw	5174	6	of	of	IN
cord-001835-0s7ok4uw	5174	7	genetic	genetic	JJ
cord-001835-0s7ok4uw	5174	8	tools	tool	NNS
cord-001835-0s7ok4uw	5174	9	providing	provide	VBG
cord-001835-0s7ok4uw	5174	10	for	for	IN
cord-001835-0s7ok4uw	5174	11	conditional	conditional	JJ
cord-001835-0s7ok4uw	5174	12	induction	induction	NN
cord-001835-0s7ok4uw	5174	13	and	and	CC
cord-001835-0s7ok4uw	5174	14	repression	repression	NN
cord-001835-0s7ok4uw	5174	15	of	of	IN
cord-001835-0s7ok4uw	5174	16	nucleoporins	nucleoporin	NNS
cord-001835-0s7ok4uw	5174	17	.	.	.
cord-001835-0s7ok4uw	5175	1	By	by	IN
cord-001835-0s7ok4uw	5175	2	combining	combine	VBG
cord-001835-0s7ok4uw	5175	3	these	these	DT
cord-001835-0s7ok4uw	5175	4	switches	switch	NNS
cord-001835-0s7ok4uw	5175	5	with	with	IN
cord-001835-0s7ok4uw	5175	6	stable	stable	JJ
cord-001835-0s7ok4uw	5175	7	isotope	isotope	NN
cord-001835-0s7ok4uw	5175	8	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	5175	9	labeling	labeling	NN
cord-001835-0s7ok4uw	5175	10	and	and	CC
cord-001835-0s7ok4uw	5175	11	affinity	affinity	NN
cord-001835-0s7ok4uw	5175	12	capture	capture	NN
cord-001835-0s7ok4uw	5175	13	,	,	,
cord-001835-0s7ok4uw	5175	14	cross	cross	NN
cord-001835-0s7ok4uw	5175	15	linking	linking	NN
cord-001835-0s7ok4uw	5175	16	coupled	couple	VBN
cord-001835-0s7ok4uw	5175	17	to	to	IN
cord-001835-0s7ok4uw	5175	18	mass	mass	NN
cord-001835-0s7ok4uw	5175	19	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	5175	20	,	,	,
cord-001835-0s7ok4uw	5175	21	we	-PRON-	PRP
cord-001835-0s7ok4uw	5175	22	are	be	VBP
cord-001835-0s7ok4uw	5175	23	able	able	JJ
cord-001835-0s7ok4uw	5175	24	to	to	TO
cord-001835-0s7ok4uw	5175	25	distinguish	distinguish	VB
cord-001835-0s7ok4uw	5175	26	between	between	IN
cord-001835-0s7ok4uw	5175	27	pre	pre	JJ
cord-001835-0s7ok4uw	5175	28	-	-	JJ
cord-001835-0s7ok4uw	5175	29	existing	existing	JJ
cord-001835-0s7ok4uw	5175	30	and	and	CC
cord-001835-0s7ok4uw	5175	31	newly	newly	RB
cord-001835-0s7ok4uw	5175	32	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	5175	33	proteins	protein	NNS
cord-001835-0s7ok4uw	5175	34	and	and	CC
cord-001835-0s7ok4uw	5175	35	quantify	quantify	VB
cord-001835-0s7ok4uw	5175	36	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5175	37	relative	relative	JJ
cord-001835-0s7ok4uw	5175	38	amounts	amount	NNS
cord-001835-0s7ok4uw	5175	39	in	in	IN
cord-001835-0s7ok4uw	5175	40	the	the	DT
cord-001835-0s7ok4uw	5175	41	NPC	NPC	NNP
cord-001835-0s7ok4uw	5175	42	.	.	.
cord-001835-0s7ok4uw	5176	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	5176	2	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	5176	3	findings	finding	NNS
cord-001835-0s7ok4uw	5176	4	are	be	VBP
cord-001835-0s7ok4uw	5176	5	in	in	IN
cord-001835-0s7ok4uw	5176	6	agreement	agreement	NN
cord-001835-0s7ok4uw	5176	7	with	with	IN
cord-001835-0s7ok4uw	5176	8	results	result	NNS
cord-001835-0s7ok4uw	5176	9	obtained	obtain	VBN
cord-001835-0s7ok4uw	5176	10	in	in	IN
cord-001835-0s7ok4uw	5176	11	other	other	JJ
cord-001835-0s7ok4uw	5176	12	organisms	organism	NNS
cord-001835-0s7ok4uw	5176	13	:	:	:
cord-001835-0s7ok4uw	5176	14	the	the	DT
cord-001835-0s7ok4uw	5176	15	core	core	NN
cord-001835-0s7ok4uw	5176	16	scaffold	scaffold	NN
cord-001835-0s7ok4uw	5176	17	of	of	IN
cord-001835-0s7ok4uw	5176	18	the	the	DT
cord-001835-0s7ok4uw	5176	19	NPC	NPC	NNP
cord-001835-0s7ok4uw	5176	20	(	(	-LRB-
cord-001835-0s7ok4uw	5176	21	inner	inner	JJ
cord-001835-0s7ok4uw	5176	22	ring	ring	NN
cord-001835-0s7ok4uw	5176	23	,	,	,
cord-001835-0s7ok4uw	5176	24	outer	outer	JJ
cord-001835-0s7ok4uw	5176	25	ring	ring	NN
cord-001835-0s7ok4uw	5176	26	)	)	-RRB-
cord-001835-0s7ok4uw	5176	27	appears	appear	VBZ
cord-001835-0s7ok4uw	5176	28	to	to	TO
cord-001835-0s7ok4uw	5176	29	be	be	VB
cord-001835-0s7ok4uw	5176	30	stable	stable	JJ
cord-001835-0s7ok4uw	5176	31	,	,	,
cord-001835-0s7ok4uw	5176	32	however	however	RB
cord-001835-0s7ok4uw	5176	33	does	do	VBZ
cord-001835-0s7ok4uw	5176	34	exchange	exchange	VB
cord-001835-0s7ok4uw	5176	35	slowly	slowly	RB
cord-001835-0s7ok4uw	5176	36	over	over	IN
cord-001835-0s7ok4uw	5176	37	time	time	NN
cord-001835-0s7ok4uw	5176	38	,	,	,
cord-001835-0s7ok4uw	5176	39	while	while	IN
cord-001835-0s7ok4uw	5176	40	peripheral	peripheral	JJ
cord-001835-0s7ok4uw	5176	41	components	component	NNS
cord-001835-0s7ok4uw	5176	42	exchange	exchange	VBP
cord-001835-0s7ok4uw	5176	43	faster	fast	RBR
cord-001835-0s7ok4uw	5176	44	.	.	.
cord-001835-0s7ok4uw	5177	1	By	by	IN
cord-001835-0s7ok4uw	5177	2	looking	look	VBG
cord-001835-0s7ok4uw	5177	3	at	at	IN
cord-001835-0s7ok4uw	5177	4	the	the	DT
cord-001835-0s7ok4uw	5177	5	exchange	exchange	NN
cord-001835-0s7ok4uw	5177	6	rates	rate	NNS
cord-001835-0s7ok4uw	5177	7	of	of	IN
cord-001835-0s7ok4uw	5177	8	yeast	yeast	NN
cord-001835-0s7ok4uw	5177	9	nucleoporins	nucleoporin	NNS
cord-001835-0s7ok4uw	5177	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	5177	11	hope	hope	VBP
cord-001835-0s7ok4uw	5177	12	to	to	TO
cord-001835-0s7ok4uw	5177	13	gain	gain	VB
cord-001835-0s7ok4uw	5177	14	insight	insight	NN
cord-001835-0s7ok4uw	5177	15	into	into	IN
cord-001835-0s7ok4uw	5177	16	the	the	DT
cord-001835-0s7ok4uw	5177	17	NPC	NPC	NNP
cord-001835-0s7ok4uw	5177	18	biology	biology	NN
cord-001835-0s7ok4uw	5177	19	of	of	IN
cord-001835-0s7ok4uw	5177	20	actively	actively	RB
cord-001835-0s7ok4uw	5177	21	dividing	divide	VBG
cord-001835-0s7ok4uw	5177	22	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	5177	23	cells	cell	NNS
cord-001835-0s7ok4uw	5177	24	.	.	.
cord-001835-0s7ok4uw	5178	1	Active	active	JJ
cord-001835-0s7ok4uw	5178	2	site	site	NN
cord-001835-0s7ok4uw	5178	3	clustering	clustering	NN
cord-001835-0s7ok4uw	5178	4	identifies	identify	VBZ
cord-001835-0s7ok4uw	5178	5	functional	functional	JJ
cord-001835-0s7ok4uw	5178	6	families	family	NNS
cord-001835-0s7ok4uw	5178	7	of	of	IN
cord-001835-0s7ok4uw	5178	8	the	the	DT
cord-001835-0s7ok4uw	5178	9	peroxiredoxin	peroxiredoxin	JJ
cord-001835-0s7ok4uw	5178	10	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5178	11	Angela	Angela	NNP
cord-001835-0s7ok4uw	5178	12	Harper	Harper	NNP
cord-001835-0s7ok4uw	5178	13	1	1	CD
cord-001835-0s7ok4uw	5178	14	,	,	,
cord-001835-0s7ok4uw	5178	15	Janelle	Janelle	NNP
cord-001835-0s7ok4uw	5178	16	Leuthaeuser	Leuthaeuser	NNP
cord-001835-0s7ok4uw	5178	17	2	2	CD
cord-001835-0s7ok4uw	5178	18	,	,	,
cord-001835-0s7ok4uw	5178	19	Patricia	Patricia	NNP
cord-001835-0s7ok4uw	5178	20	Babbitt	Babbitt	NNP
cord-001835-0s7ok4uw	5178	21	2	2	CD
cord-001835-0s7ok4uw	5178	22	,	,	,
cord-001835-0s7ok4uw	5178	23	Jacquelyn	Jacquelyn	NNP
cord-001835-0s7ok4uw	5178	24	Fetrow	Fetrow	NNP
cord-001835-0s7ok4uw	5178	25	3	3	CD
cord-001835-0s7ok4uw	5178	26	1	1	CD
cord-001835-0s7ok4uw	5178	27	Department	Department	NNP
cord-001835-0s7ok4uw	5178	28	of	of	IN
cord-001835-0s7ok4uw	5178	29	Physics	Physics	NNP
cord-001835-0s7ok4uw	5178	30	,	,	,
cord-001835-0s7ok4uw	5178	31	Wake	Wake	NNP
cord-001835-0s7ok4uw	5178	32	Forest	Forest	NNP
cord-001835-0s7ok4uw	5178	33	University	University	NNP
cord-001835-0s7ok4uw	5178	34	,	,	,
cord-001835-0s7ok4uw	5178	35	2	2	CD
cord-001835-0s7ok4uw	5178	36	Department	Department	NNP
cord-001835-0s7ok4uw	5178	37	of	of	IN
cord-001835-0s7ok4uw	5178	38	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	5178	39	Genetics	Genetics	NNP
cord-001835-0s7ok4uw	5178	40	and	and	CC
cord-001835-0s7ok4uw	5178	41	Genomics,-Wake	Genomics,-Wake	NNP
cord-001835-0s7ok4uw	5178	42	Forest	Forest	NNP
cord-001835-0s7ok4uw	5178	43	University	University	NNP
cord-001835-0s7ok4uw	5178	44	,	,	,
cord-001835-0s7ok4uw	5178	45	3	3	CD
cord-001835-0s7ok4uw	5178	46	Departments	Departments	NNPS
cord-001835-0s7ok4uw	5178	47	of	of	IN
cord-001835-0s7ok4uw	5178	48	Physics	Physics	NNP
cord-001835-0s7ok4uw	5178	49	and	and	CC
cord-001835-0s7ok4uw	5178	50	Computer	Computer	NNP
cord-001835-0s7ok4uw	5178	51	Science	Science	NNP
cord-001835-0s7ok4uw	5178	52	,	,	,
cord-001835-0s7ok4uw	5178	53	Wake	Wake	NNP
cord-001835-0s7ok4uw	5178	54	Forest	Forest	NNP
cord-001835-0s7ok4uw	5178	55	University	University	NNP
cord-001835-0s7ok4uw	5178	56	Bioinformatics	Bioinformatics	NNP
cord-001835-0s7ok4uw	5178	57	Understanding	understand	VBG
cord-001835-0s7ok4uw	5178	58	the	the	DT
cord-001835-0s7ok4uw	5178	59	relationships	relationship	NNS
cord-001835-0s7ok4uw	5178	60	between	between	IN
cord-001835-0s7ok4uw	5178	61	proteins	protein	NNS
cord-001835-0s7ok4uw	5178	62	is	be	VBZ
cord-001835-0s7ok4uw	5178	63	vital	vital	JJ
cord-001835-0s7ok4uw	5178	64	to	to	IN
cord-001835-0s7ok4uw	5178	65	increasing	increase	VBG
cord-001835-0s7ok4uw	5178	66	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5178	67	knowledge	knowledge	NN
cord-001835-0s7ok4uw	5178	68	of	of	IN
cord-001835-0s7ok4uw	5178	69	the	the	DT
cord-001835-0s7ok4uw	5178	70	protein	protein	NN
cord-001835-0s7ok4uw	5178	71	universe	universe	NN
cord-001835-0s7ok4uw	5178	72	.	.	.
cord-001835-0s7ok4uw	5179	1	While	while	IN
cord-001835-0s7ok4uw	5179	2	there	there	EX
cord-001835-0s7ok4uw	5179	3	are	be	VBP
cord-001835-0s7ok4uw	5179	4	large	large	JJ
cord-001835-0s7ok4uw	5179	5	databases	database	NNS
cord-001835-0s7ok4uw	5179	6	of	of	IN
cord-001835-0s7ok4uw	5179	7	sequence	sequence	NN
cord-001835-0s7ok4uw	5179	8	information	information	NN
cord-001835-0s7ok4uw	5179	9	,	,	,
cord-001835-0s7ok4uw	5179	10	the	the	DT
cord-001835-0s7ok4uw	5179	11	massive	massive	JJ
cord-001835-0s7ok4uw	5179	12	data	data	NN
cord-001835-0s7ok4uw	5179	13	influx	influx	NN
cord-001835-0s7ok4uw	5179	14	over	over	IN
cord-001835-0s7ok4uw	5179	15	the	the	DT
cord-001835-0s7ok4uw	5179	16	past	past	JJ
cord-001835-0s7ok4uw	5179	17	decade	decade	NN
cord-001835-0s7ok4uw	5179	18	has	have	VBZ
cord-001835-0s7ok4uw	5179	19	prevented	prevent	VBN
cord-001835-0s7ok4uw	5179	20	adequate	adequate	JJ
cord-001835-0s7ok4uw	5179	21	classification	classification	NN
cord-001835-0s7ok4uw	5179	22	of	of	IN
cord-001835-0s7ok4uw	5179	23	proteins	protein	NNS
cord-001835-0s7ok4uw	5179	24	at	at	IN
cord-001835-0s7ok4uw	5179	25	the	the	DT
cord-001835-0s7ok4uw	5179	26	molecular	molecular	JJ
cord-001835-0s7ok4uw	5179	27	function	function	NN
cord-001835-0s7ok4uw	5179	28	level	level	NN
cord-001835-0s7ok4uw	5179	29	.	.	.
cord-001835-0s7ok4uw	5180	1	However	however	RB
cord-001835-0s7ok4uw	5180	2	,	,	,
cord-001835-0s7ok4uw	5180	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	5180	4	has	have	VBZ
cord-001835-0s7ok4uw	5180	5	been	be	VBN
cord-001835-0s7ok4uw	5180	6	previously	previously	RB
cord-001835-0s7ok4uw	5180	7	suggested	suggest	VBN
cord-001835-0s7ok4uw	5180	8	that	that	IN
cord-001835-0s7ok4uw	5180	9	a	a	DT
cord-001835-0s7ok4uw	5180	10	protein	protein	NN
cord-001835-0s7ok4uw	5180	11	's	's	POS
cord-001835-0s7ok4uw	5180	12	active	active	JJ
cord-001835-0s7ok4uw	5180	13	site	site	NN
cord-001835-0s7ok4uw	5180	14	information	information	NN
cord-001835-0s7ok4uw	5180	15	may	may	MD
cord-001835-0s7ok4uw	5180	16	correlate	correlate	VB
cord-001835-0s7ok4uw	5180	17	with	with	IN
cord-001835-0s7ok4uw	5180	18	these	these	DT
cord-001835-0s7ok4uw	5180	19	known	know	VBN
cord-001835-0s7ok4uw	5180	20	molecular	molecular	JJ
cord-001835-0s7ok4uw	5180	21	functional	functional	JJ
cord-001835-0s7ok4uw	5180	22	differences	difference	NNS
cord-001835-0s7ok4uw	5180	23	;	;	:
cord-001835-0s7ok4uw	5180	24	thus	thus	RB
cord-001835-0s7ok4uw	5180	25	,	,	,
cord-001835-0s7ok4uw	5180	26	active	active	JJ
cord-001835-0s7ok4uw	5180	27	site	site	NN
cord-001835-0s7ok4uw	5180	28	profiling	profiling	NN
cord-001835-0s7ok4uw	5180	29	was	be	VBD
cord-001835-0s7ok4uw	5180	30	developed	develop	VBN
cord-001835-0s7ok4uw	5180	31	to	to	TO
cord-001835-0s7ok4uw	5180	32	use	use	VB
cord-001835-0s7ok4uw	5180	33	residues	residue	NNS
cord-001835-0s7ok4uw	5180	34	around	around	IN
cord-001835-0s7ok4uw	5180	35	the	the	DT
cord-001835-0s7ok4uw	5180	36	active	active	JJ
cord-001835-0s7ok4uw	5180	37	site	site	NN
cord-001835-0s7ok4uw	5180	38	of	of	IN
cord-001835-0s7ok4uw	5180	39	a	a	DT
cord-001835-0s7ok4uw	5180	40	protein	protein	NN
cord-001835-0s7ok4uw	5180	41	to	to	TO
cord-001835-0s7ok4uw	5180	42	relate	relate	VB
cord-001835-0s7ok4uw	5180	43	proteins	protein	NNS
cord-001835-0s7ok4uw	5180	44	.	.	.
cord-001835-0s7ok4uw	5181	1	Subsequently	subsequently	RB
cord-001835-0s7ok4uw	5181	2	the	the	DT
cord-001835-0s7ok4uw	5181	3	Deacon	Deacon	NNP
cord-001835-0s7ok4uw	5181	4	Active	Active	NNP
cord-001835-0s7ok4uw	5181	5	Site	Site	NNP
cord-001835-0s7ok4uw	5181	6	Profiler	profiler	NN
cord-001835-0s7ok4uw	5181	7	(	(	-LRB-
cord-001835-0s7ok4uw	5181	8	DASP	DASP	NNP
cord-001835-0s7ok4uw	5181	9	)	)	-RRB-
cord-001835-0s7ok4uw	5181	10	was	be	VBD
cord-001835-0s7ok4uw	5181	11	developed	develop	VBN
cord-001835-0s7ok4uw	5181	12	to	to	TO
cord-001835-0s7ok4uw	5181	13	create	create	VB
cord-001835-0s7ok4uw	5181	14	these	these	DT
cord-001835-0s7ok4uw	5181	15	active	active	JJ
cord-001835-0s7ok4uw	5181	16	site	site	NN
cord-001835-0s7ok4uw	5181	17	profiles	profile	NNS
cord-001835-0s7ok4uw	5181	18	and	and	CC
cord-001835-0s7ok4uw	5181	19	search	search	VB
cord-001835-0s7ok4uw	5181	20	them	-PRON-	PRP
cord-001835-0s7ok4uw	5181	21	in	in	IN
cord-001835-0s7ok4uw	5181	22	a	a	DT
cord-001835-0s7ok4uw	5181	23	database	database	NN
cord-001835-0s7ok4uw	5181	24	,	,	,
cord-001835-0s7ok4uw	5181	25	such	such	JJ
cord-001835-0s7ok4uw	5181	26	as	as	IN
cord-001835-0s7ok4uw	5181	27	Gen	Gen	NNP
cord-001835-0s7ok4uw	5181	28	-	-	HYPH
cord-001835-0s7ok4uw	5181	29	Bank	Bank	NNP
cord-001835-0s7ok4uw	5181	30	,	,	,
cord-001835-0s7ok4uw	5181	31	in	in	IN
cord-001835-0s7ok4uw	5181	32	order	order	NN
cord-001835-0s7ok4uw	5181	33	to	to	TO
cord-001835-0s7ok4uw	5181	34	find	find	VB
cord-001835-0s7ok4uw	5181	35	proteins	protein	NNS
cord-001835-0s7ok4uw	5181	36	with	with	IN
cord-001835-0s7ok4uw	5181	37	similar	similar	JJ
cord-001835-0s7ok4uw	5181	38	active	active	JJ
cord-001835-0s7ok4uw	5181	39	site	site	NN
cord-001835-0s7ok4uw	5181	40	environments	environment	NNS
cord-001835-0s7ok4uw	5181	41	.	.	.
cord-001835-0s7ok4uw	5182	1	By	by	IN
cord-001835-0s7ok4uw	5182	2	using	use	VBG
cord-001835-0s7ok4uw	5182	3	DASP	DASP	NNP
cord-001835-0s7ok4uw	5182	4	to	to	IN
cord-001835-0s7ok4uw	5182	5	computationally	computationally	RB
cord-001835-0s7ok4uw	5182	6	cluster	cluster	JJ
cord-001835-0s7ok4uw	5182	7	proteins	protein	NNS
cord-001835-0s7ok4uw	5182	8	based	base	VBN
cord-001835-0s7ok4uw	5182	9	on	on	IN
cord-001835-0s7ok4uw	5182	10	the	the	DT
cord-001835-0s7ok4uw	5182	11	similarity	similarity	NN
cord-001835-0s7ok4uw	5182	12	of	of	IN
cord-001835-0s7ok4uw	5182	13	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5182	14	active	active	JJ
cord-001835-0s7ok4uw	5182	15	site	site	NN
cord-001835-0s7ok4uw	5182	16	profiles	profile	NNS
cord-001835-0s7ok4uw	5182	17	,	,	,
cord-001835-0s7ok4uw	5182	18	the	the	DT
cord-001835-0s7ok4uw	5182	19	Peroxiredoxin	Peroxiredoxin	NNP
cord-001835-0s7ok4uw	5182	20	(	(	-LRB-
cord-001835-0s7ok4uw	5182	21	Prx	Prx	NNP
cord-001835-0s7ok4uw	5182	22	)	)	-RRB-
cord-001835-0s7ok4uw	5182	23	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5182	24	was	be	VBD
cord-001835-0s7ok4uw	5182	25	analyzed	analyze	VBN
cord-001835-0s7ok4uw	5182	26	through	through	IN
cord-001835-0s7ok4uw	5182	27	active	active	JJ
cord-001835-0s7ok4uw	5182	28	site	site	NN
cord-001835-0s7ok4uw	5182	29	similarity	similarity	NN
cord-001835-0s7ok4uw	5182	30	methods	method	NNS
cord-001835-0s7ok4uw	5182	31	.	.	.
cord-001835-0s7ok4uw	5183	1	The	the	DT
cord-001835-0s7ok4uw	5183	2	residues	residue	NNS
cord-001835-0s7ok4uw	5183	3	from	from	IN
cord-001835-0s7ok4uw	5183	4	the	the	DT
cord-001835-0s7ok4uw	5183	5	active	active	JJ
cord-001835-0s7ok4uw	5183	6	site	site	NN
cord-001835-0s7ok4uw	5183	7	of	of	IN
cord-001835-0s7ok4uw	5183	8	each	each	DT
cord-001835-0s7ok4uw	5183	9	Prx	Prx	NNP
cord-001835-0s7ok4uw	5183	10	structure	structure	NN
cord-001835-0s7ok4uw	5183	11	were	be	VBD
cord-001835-0s7ok4uw	5183	12	extracted	extract	VBN
cord-001835-0s7ok4uw	5183	13	and	and	CC
cord-001835-0s7ok4uw	5183	14	clustered	cluster	VBN
cord-001835-0s7ok4uw	5183	15	,	,	,
cord-001835-0s7ok4uw	5183	16	and	and	CC
cord-001835-0s7ok4uw	5183	17	these	these	DT
cord-001835-0s7ok4uw	5183	18	profiles	profile	NNS
cord-001835-0s7ok4uw	5183	19	were	be	VBD
cord-001835-0s7ok4uw	5183	20	iteratively	iteratively	RB
cord-001835-0s7ok4uw	5183	21	searched	search	VBN
cord-001835-0s7ok4uw	5183	22	in	in	IN
cord-001835-0s7ok4uw	5183	23	GenBank	GenBank	NNP
cord-001835-0s7ok4uw	5183	24	through	through	IN
cord-001835-0s7ok4uw	5183	25	a	a	DT
cord-001835-0s7ok4uw	5183	26	Multi	multi	JJ
cord-001835-0s7ok4uw	5183	27	-	-	JJ
cord-001835-0s7ok4uw	5183	28	level	level	JJ
cord-001835-0s7ok4uw	5183	29	Iterative	iterative	JJ
cord-001835-0s7ok4uw	5183	30	Sequence	sequence	NN
cord-001835-0s7ok4uw	5183	31	Searching	Searching	NNP
cord-001835-0s7ok4uw	5183	32	Technique	technique	NN
cord-001835-0s7ok4uw	5183	33	(	(	-LRB-
cord-001835-0s7ok4uw	5183	34	MISST	MISST	NNP
cord-001835-0s7ok4uw	5183	35	)	)	-RRB-
cord-001835-0s7ok4uw	5183	36	.	.	.
cord-001835-0s7ok4uw	5184	1	The	the	DT
cord-001835-0s7ok4uw	5184	2	Prx	Prx	NNP
cord-001835-0s7ok4uw	5184	3	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5184	4	has	have	VBZ
cord-001835-0s7ok4uw	5184	5	been	be	VBN
cord-001835-0s7ok4uw	5184	6	studied	study	VBN
cord-001835-0s7ok4uw	5184	7	by	by	IN
cord-001835-0s7ok4uw	5184	8	experts	expert	NNS
cord-001835-0s7ok4uw	5184	9	,	,	,
cord-001835-0s7ok4uw	5184	10	allowing	allow	VBG
cord-001835-0s7ok4uw	5184	11	the	the	DT
cord-001835-0s7ok4uw	5184	12	results	result	NNS
cord-001835-0s7ok4uw	5184	13	of	of	IN
cord-001835-0s7ok4uw	5184	14	these	these	DT
cord-001835-0s7ok4uw	5184	15	searches	search	NNS
cord-001835-0s7ok4uw	5184	16	to	to	TO
cord-001835-0s7ok4uw	5184	17	be	be	VB
cord-001835-0s7ok4uw	5184	18	compared	compare	VBN
cord-001835-0s7ok4uw	5184	19	to	to	IN
cord-001835-0s7ok4uw	5184	20	a	a	DT
cord-001835-0s7ok4uw	5184	21	well	well	RB
cord-001835-0s7ok4uw	5184	22	-	-	HYPH
cord-001835-0s7ok4uw	5184	23	annotated	annotate	VBN
cord-001835-0s7ok4uw	5184	24	group	group	NN
cord-001835-0s7ok4uw	5184	25	of	of	IN
cord-001835-0s7ok4uw	5184	26	proteins	protein	NNS
cord-001835-0s7ok4uw	5184	27	.	.	.
cord-001835-0s7ok4uw	5185	1	While	while	IN
cord-001835-0s7ok4uw	5185	2	previous	previous	JJ
cord-001835-0s7ok4uw	5185	3	sequence	sequence	NN
cord-001835-0s7ok4uw	5185	4	based	base	VBN
cord-001835-0s7ok4uw	5185	5	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	5185	6	methods	method	NNS
cord-001835-0s7ok4uw	5185	7	have	have	VBP
cord-001835-0s7ok4uw	5185	8	been	be	VBN
cord-001835-0s7ok4uw	5185	9	unable	unable	JJ
cord-001835-0s7ok4uw	5185	10	to	to	TO
cord-001835-0s7ok4uw	5185	11	identify	identify	VB
cord-001835-0s7ok4uw	5185	12	functional	functional	JJ
cord-001835-0s7ok4uw	5185	13	differences	difference	NNS
cord-001835-0s7ok4uw	5185	14	between	between	IN
cord-001835-0s7ok4uw	5185	15	some	some	DT
cord-001835-0s7ok4uw	5185	16	subgroups	subgroup	NNS
cord-001835-0s7ok4uw	5185	17	of	of	IN
cord-001835-0s7ok4uw	5185	18	the	the	DT
cord-001835-0s7ok4uw	5185	19	Prxs	Prxs	NNPS
cord-001835-0s7ok4uw	5185	20	,	,	,
cord-001835-0s7ok4uw	5185	21	notably	notably	RB
cord-001835-0s7ok4uw	5185	22	the	the	DT
cord-001835-0s7ok4uw	5185	23	AhpC	AhpC	NNP
cord-001835-0s7ok4uw	5185	24	-	-	HYPH
cord-001835-0s7ok4uw	5185	25	Prx1	Prx1	NNP
cord-001835-0s7ok4uw	5185	26	and	and	CC
cord-001835-0s7ok4uw	5185	27	Prx6	Prx6	NNP
cord-001835-0s7ok4uw	5185	28	subgroups	subgroup	NNS
cord-001835-0s7ok4uw	5185	29	,	,	,
cord-001835-0s7ok4uw	5185	30	MISST	MISST	NNP
cord-001835-0s7ok4uw	5185	31	discretely	discretely	RB
cord-001835-0s7ok4uw	5185	32	separates	separate	VBZ
cord-001835-0s7ok4uw	5185	33	these	these	DT
cord-001835-0s7ok4uw	5185	34	subgroups	subgroup	NNS
cord-001835-0s7ok4uw	5185	35	.	.	.
cord-001835-0s7ok4uw	5186	1	Classifying	classify	VBG
cord-001835-0s7ok4uw	5186	2	Prx	Prx	NNP
cord-001835-0s7ok4uw	5186	3	proteins	protein	NNS
cord-001835-0s7ok4uw	5186	4	into	into	IN
cord-001835-0s7ok4uw	5186	5	functionally	functionally	RB
cord-001835-0s7ok4uw	5186	6	relevant	relevant	JJ
cord-001835-0s7ok4uw	5186	7	groups	group	NNS
cord-001835-0s7ok4uw	5186	8	using	use	VBG
cord-001835-0s7ok4uw	5186	9	computational	computational	JJ
cord-001835-0s7ok4uw	5186	10	active	active	JJ
cord-001835-0s7ok4uw	5186	11	site	site	NN
cord-001835-0s7ok4uw	5186	12	similarity	similarity	NN
cord-001835-0s7ok4uw	5186	13	methods	method	NNS
cord-001835-0s7ok4uw	5186	14	lays	lay	VBZ
cord-001835-0s7ok4uw	5186	15	the	the	DT
cord-001835-0s7ok4uw	5186	16	foundation	foundation	NN
cord-001835-0s7ok4uw	5186	17	for	for	IN
cord-001835-0s7ok4uw	5186	18	an	an	DT
cord-001835-0s7ok4uw	5186	19	automated	automated	JJ
cord-001835-0s7ok4uw	5186	20	process	process	NN
cord-001835-0s7ok4uw	5186	21	for	for	IN
cord-001835-0s7ok4uw	5186	22	identifying	identify	VBG
cord-001835-0s7ok4uw	5186	23	protein	protein	NN
cord-001835-0s7ok4uw	5186	24	functional	functional	JJ
cord-001835-0s7ok4uw	5186	25	groups	group	NNS
cord-001835-0s7ok4uw	5186	26	beyond	beyond	IN
cord-001835-0s7ok4uw	5186	27	the	the	DT
cord-001835-0s7ok4uw	5186	28	Prx	Prx	NNP
cord-001835-0s7ok4uw	5186	29	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5186	30	.	.	.
cord-001835-0s7ok4uw	5187	1	Synthesis	synthesis	NN
cord-001835-0s7ok4uw	5187	2	and	and	CC
cord-001835-0s7ok4uw	5187	3	conformational	conformational	JJ
cord-001835-0s7ok4uw	5187	4	studies	study	NNS
cord-001835-0s7ok4uw	5187	5	of	of	IN
cord-001835-0s7ok4uw	5187	6	glycoprotein	glycoprotein	NN
cord-001835-0s7ok4uw	5187	7	N	n	CD
cord-001835-0s7ok4uw	5187	8	homolog	homolog	NN
cord-001835-0s7ok4uw	5187	9	of	of	IN
cord-001835-0s7ok4uw	5187	10	bovine	bovine	JJ
cord-001835-0s7ok4uw	5187	11	herpesvirus	herpesvirus	NN
cord-001835-0s7ok4uw	5187	12	1	1	CD
cord-001835-0s7ok4uw	5187	13	(	(	-LRB-
cord-001835-0s7ok4uw	5187	14	BHV-1	BHV-1	NNP
cord-001835-0s7ok4uw	5187	15	)	)	-RRB-
cord-001835-0s7ok4uw	5187	16	by	by	IN
cord-001835-0s7ok4uw	5187	17	using	use	VBG
cord-001835-0s7ok4uw	5187	18	CD	CD	NNP
cord-001835-0s7ok4uw	5187	19	,	,	,
cord-001835-0s7ok4uw	5187	20	NMR	NMR	NNP
cord-001835-0s7ok4uw	5187	21	and	and	CC
cord-001835-0s7ok4uw	5187	22	molecular	molecular	JJ
cord-001835-0s7ok4uw	5187	23	modelling	modelling	NN
cord-001835-0s7ok4uw	5187	24	it	-PRON-	PRP
cord-001835-0s7ok4uw	5187	25	serves	serve	VBZ
cord-001835-0s7ok4uw	5187	26	as	as	IN
cord-001835-0s7ok4uw	5187	27	a	a	DT
cord-001835-0s7ok4uw	5187	28	chaperone	chaperone	NN
cord-001835-0s7ok4uw	5187	29	for	for	IN
cord-001835-0s7ok4uw	5187	30	viral	viral	JJ
cord-001835-0s7ok4uw	5187	31	glycoprotein	glycoprotein	NN
cord-001835-0s7ok4uw	5187	32	M	M	NNP
cord-001835-0s7ok4uw	5187	33	and	and	CC
cord-001835-0s7ok4uw	5187	34	,	,	,
cord-001835-0s7ok4uw	5187	35	in	in	IN
cord-001835-0s7ok4uw	5187	36	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5187	37	gM	gm	NN
cord-001835-0s7ok4uw	5187	38	-	-	HYPH
cord-001835-0s7ok4uw	5187	39	unbound	unbound	JJ
cord-001835-0s7ok4uw	5187	40	form	form	NN
cord-001835-0s7ok4uw	5187	41	,	,	,
cord-001835-0s7ok4uw	5187	42	acts	act	VBZ
cord-001835-0s7ok4uw	5187	43	as	as	IN
cord-001835-0s7ok4uw	5187	44	an	an	DT
cord-001835-0s7ok4uw	5187	45	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	5187	46	constraining	constrain	VBG
cord-001835-0s7ok4uw	5187	47	the	the	DT
cord-001835-0s7ok4uw	5187	48	transporter	transporter	NN
cord-001835-0s7ok4uw	5187	49	associated	associate	VBN
cord-001835-0s7ok4uw	5187	50	with	with	IN
cord-001835-0s7ok4uw	5187	51	antigen	antigen	NN
cord-001835-0s7ok4uw	5187	52	processing	processing	NN
cord-001835-0s7ok4uw	5187	53	(	(	-LRB-
cord-001835-0s7ok4uw	5187	54	TAP	tap	NN
cord-001835-0s7ok4uw	5187	55	)	)	-RRB-
cord-001835-0s7ok4uw	5187	56	.	.	.
cord-001835-0s7ok4uw	5188	1	The	the	DT
cord-001835-0s7ok4uw	5188	2	UL49.5	ul49.5	JJ
cord-001835-0s7ok4uw	5188	3	/	/	SYM
cord-001835-0s7ok4uw	5188	4	gM	gm	NN
cord-001835-0s7ok4uw	5188	5	complex	complex	JJ
cord-001835-0s7ok4uw	5188	6	formation	formation	NN
cord-001835-0s7ok4uw	5188	7	is	be	VBZ
cord-001835-0s7ok4uw	5188	8	required	require	VBN
cord-001835-0s7ok4uw	5188	9	for	for	IN
cord-001835-0s7ok4uw	5188	10	the	the	DT
cord-001835-0s7ok4uw	5188	11	maturation	maturation	NN
cord-001835-0s7ok4uw	5188	12	and	and	CC
cord-001835-0s7ok4uw	5188	13	proper	proper	JJ
cord-001835-0s7ok4uw	5188	14	trafficking	trafficking	NN
cord-001835-0s7ok4uw	5188	15	of	of	IN
cord-001835-0s7ok4uw	5188	16	both	both	DT
cord-001835-0s7ok4uw	5188	17	viral	viral	JJ
cord-001835-0s7ok4uw	5188	18	proteins	protein	NNS
cord-001835-0s7ok4uw	5188	19	.	.	.
cord-001835-0s7ok4uw	5189	1	In	in	IN
cord-001835-0s7ok4uw	5189	2	the	the	DT
cord-001835-0s7ok4uw	5189	3	absence	absence	NN
cord-001835-0s7ok4uw	5189	4	of	of	IN
cord-001835-0s7ok4uw	5189	5	gM	gm	NN
cord-001835-0s7ok4uw	5189	6	,	,	,
cord-001835-0s7ok4uw	5189	7	UL49.5	ul49.5	JJ
cord-001835-0s7ok4uw	5189	8	blocks	block	NNS
cord-001835-0s7ok4uw	5189	9	transport	transport	NN
cord-001835-0s7ok4uw	5189	10	of	of	IN
cord-001835-0s7ok4uw	5189	11	antigenic	antigenic	JJ
cord-001835-0s7ok4uw	5189	12	peptides	peptide	NNS
cord-001835-0s7ok4uw	5189	13	by	by	IN
cord-001835-0s7ok4uw	5189	14	TAP	tap	NN
cord-001835-0s7ok4uw	5189	15	and	and	CC
cord-001835-0s7ok4uw	5189	16	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5189	17	MHC	MHC	NNP
cord-001835-0s7ok4uw	5189	18	I	i	NN
cord-001835-0s7ok4uw	5189	19	-	-	HYPH
cord-001835-0s7ok4uw	5189	20	restricted	restrict	VBN
cord-001835-0s7ok4uw	5189	21	presentation	presentation	NN
cord-001835-0s7ok4uw	5189	22	.	.	.
cord-001835-0s7ok4uw	5190	1	The	the	DT
cord-001835-0s7ok4uw	5190	2	molecular	molecular	JJ
cord-001835-0s7ok4uw	5190	3	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5190	4	of	of	IN
cord-001835-0s7ok4uw	5190	5	UL49.5	ul49.5	JJ
cord-001835-0s7ok4uw	5190	6	activity	activity	NN
cord-001835-0s7ok4uw	5190	7	still	still	RB
cord-001835-0s7ok4uw	5190	8	remains	remain	VBZ
cord-001835-0s7ok4uw	5190	9	elusive	elusive	JJ
cord-001835-0s7ok4uw	5190	10	.	.	.
cord-001835-0s7ok4uw	5191	1	In	in	IN
cord-001835-0s7ok4uw	5191	2	order	order	NN
cord-001835-0s7ok4uw	5191	3	to	to	TO
cord-001835-0s7ok4uw	5191	4	investigate	investigate	VB
cord-001835-0s7ok4uw	5191	5	the	the	DT
cord-001835-0s7ok4uw	5191	6	structural	structural	JJ
cord-001835-0s7ok4uw	5191	7	requirements	requirement	NNS
cord-001835-0s7ok4uw	5191	8	for	for	IN
cord-001835-0s7ok4uw	5191	9	biological	biological	JJ
cord-001835-0s7ok4uw	5191	10	function	function	NN
cord-001835-0s7ok4uw	5192	1	UL49.5	ul49.5	JJ
cord-001835-0s7ok4uw	5192	2	study	study	NN
cord-001835-0s7ok4uw	5192	3	was	be	VBD
cord-001835-0s7ok4uw	5192	4	conducted	conduct	VBN
cord-001835-0s7ok4uw	5192	5	using	use	VBG
cord-001835-0s7ok4uw	5192	6	CD	CD	NNP
cord-001835-0s7ok4uw	5192	7	,	,	,
cord-001835-0s7ok4uw	5192	8	NMR	NMR	NNP
cord-001835-0s7ok4uw	5192	9	and	and	CC
cord-001835-0s7ok4uw	5192	10	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	5192	11	Dynamics	Dynamics	NNPS
cord-001835-0s7ok4uw	5192	12	methods	method	NNS
cord-001835-0s7ok4uw	5192	13	.	.	.
cord-001835-0s7ok4uw	5193	1	The	the	DT
cord-001835-0s7ok4uw	5193	2	data	datum	NNS
cord-001835-0s7ok4uw	5193	3	obtained	obtain	VBN
cord-001835-0s7ok4uw	5193	4	with	with	IN
cord-001835-0s7ok4uw	5193	5	the	the	DT
cord-001835-0s7ok4uw	5193	6	use	use	NN
cord-001835-0s7ok4uw	5193	7	of	of	IN
cord-001835-0s7ok4uw	5193	8	high	high	JJ
cord-001835-0s7ok4uw	5193	9	purity	purity	NN
cord-001835-0s7ok4uw	5193	10	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	5193	11	peptides	peptide	NNS
cord-001835-0s7ok4uw	5193	12	encompassing	encompass	VBG
cord-001835-0s7ok4uw	5193	13	UL49.5	ul49.5	NN
cord-001835-0s7ok4uw	5193	14	confirmed	confirm	VBD
cord-001835-0s7ok4uw	5193	15	the	the	DT
cord-001835-0s7ok4uw	5193	16	presence	presence	NN
cord-001835-0s7ok4uw	5193	17	of	of	IN
cord-001835-0s7ok4uw	5193	18	an	an	DT
cord-001835-0s7ok4uw	5193	19	alpha	alpha	JJ
cord-001835-0s7ok4uw	5193	20	-	-	HYPH
cord-001835-0s7ok4uw	5193	21	helix	helix	NN
cord-001835-0s7ok4uw	5193	22	structure	structure	NN
cord-001835-0s7ok4uw	5193	23	,	,	,
cord-001835-0s7ok4uw	5193	24	formed	form	VBN
cord-001835-0s7ok4uw	5193	25	preferentially	preferentially	RB
cord-001835-0s7ok4uw	5193	26	in	in	IN
cord-001835-0s7ok4uw	5193	27	the	the	DT
cord-001835-0s7ok4uw	5193	28	presence	presence	NN
cord-001835-0s7ok4uw	5193	29	of	of	IN
cord-001835-0s7ok4uw	5193	30	dodecylphosphocholine	dodecylphosphocholine	NNP
cord-001835-0s7ok4uw	5193	31	(	(	-LRB-
cord-001835-0s7ok4uw	5193	32	DPC	DPC	NNP
cord-001835-0s7ok4uw	5193	33	)	)	-RRB-
cord-001835-0s7ok4uw	5193	34	micelles	micelle	NNS
cord-001835-0s7ok4uw	5193	35	as	as	IN
cord-001835-0s7ok4uw	5193	36	a	a	DT
cord-001835-0s7ok4uw	5193	37	membrane	membrane	NN
cord-001835-0s7ok4uw	5193	38	-	-	HYPH
cord-001835-0s7ok4uw	5193	39	like	like	JJ
cord-001835-0s7ok4uw	5193	40	environment	environment	NN
cord-001835-0s7ok4uw	5193	41	.	.	.
cord-001835-0s7ok4uw	5194	1	In	in	IN
cord-001835-0s7ok4uw	5194	2	order	order	NN
cord-001835-0s7ok4uw	5194	3	to	to	TO
cord-001835-0s7ok4uw	5194	4	determine	determine	VB
cord-001835-0s7ok4uw	5194	5	the	the	DT
cord-001835-0s7ok4uw	5194	6	three	three	CD
cord-001835-0s7ok4uw	5194	7	-	-	HYPH
cord-001835-0s7ok4uw	5194	8	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	5194	9	structure	structure	NN
cord-001835-0s7ok4uw	5194	10	of	of	IN
cord-001835-0s7ok4uw	5194	11	UL49.5	ul49.5	JJ
cord-001835-0s7ok4uw	5194	12	protein	protein	NN
cord-001835-0s7ok4uw	5194	13	in	in	IN
cord-001835-0s7ok4uw	5194	14	the	the	DT
cord-001835-0s7ok4uw	5194	15	present	present	JJ
cord-001835-0s7ok4uw	5194	16	work	work	NN
cord-001835-0s7ok4uw	5194	17	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5194	18	NMR	NMR	NNP
cord-001835-0s7ok4uw	5194	19	solution	solution	NN
cord-001835-0s7ok4uw	5194	20	structure	structure	NN
cord-001835-0s7ok4uw	5194	21	in	in	IN
cord-001835-0s7ok4uw	5194	22	the	the	DT
cord-001835-0s7ok4uw	5194	23	presence	presence	NN
cord-001835-0s7ok4uw	5194	24	of	of	IN
cord-001835-0s7ok4uw	5194	25	membrane	membrane	NN
cord-001835-0s7ok4uw	5194	26	-	-	HYPH
cord-001835-0s7ok4uw	5194	27	like	like	JJ
cord-001835-0s7ok4uw	5194	28	environment	environment	NN
cord-001835-0s7ok4uw	5194	29	was	be	VBD
cord-001835-0s7ok4uw	5194	30	performed	perform	VBN
cord-001835-0s7ok4uw	5194	31	.	.	.
cord-001835-0s7ok4uw	5195	1	The	the	DT
cord-001835-0s7ok4uw	5195	2	NMR	NMR	NNP
cord-001835-0s7ok4uw	5195	3	data	datum	NNS
cord-001835-0s7ok4uw	5195	4	were	be	VBD
cord-001835-0s7ok4uw	5195	5	used	use	VBN
cord-001835-0s7ok4uw	5195	6	as	as	IN
cord-001835-0s7ok4uw	5195	7	a	a	DT
cord-001835-0s7ok4uw	5195	8	set	set	NN
cord-001835-0s7ok4uw	5195	9	of	of	IN
cord-001835-0s7ok4uw	5195	10	restraints	restraint	NNS
cord-001835-0s7ok4uw	5195	11	for	for	IN
cord-001835-0s7ok4uw	5195	12	a	a	DT
cord-001835-0s7ok4uw	5195	13	simulated	simulated	JJ
cord-001835-0s7ok4uw	5195	14	annealing	annealing	NN
cord-001835-0s7ok4uw	5195	15	protocol	protocol	NN
cord-001835-0s7ok4uw	5195	16	that	that	WDT
cord-001835-0s7ok4uw	5195	17	generated	generate	VBD
cord-001835-0s7ok4uw	5195	18	3Dstructures	3dstructures	NN
cord-001835-0s7ok4uw	5195	19	of	of	IN
cord-001835-0s7ok4uw	5195	20	the	the	DT
cord-001835-0s7ok4uw	5195	21	Colin	Colin	NNP
cord-001835-0s7ok4uw	5195	22	Johnson	Johnson	NNP
cord-001835-0s7ok4uw	5195	23	1	1	CD
cord-001835-0s7ok4uw	5196	1	,	,	,
cord-001835-0s7ok4uw	5196	2	Sara	Sara	NNP
cord-001835-0s7ok4uw	5196	3	Codding	Codding	NNP
cord-001835-0s7ok4uw	5196	4	1	1	CD
cord-001835-0s7ok4uw	5196	5	1	1	CD
cord-001835-0s7ok4uw	5196	6	Membrane	membrane	NN
cord-001835-0s7ok4uw	5196	7	proteins	protein	NNS
cord-001835-0s7ok4uw	5196	8	Resealing	reseal	VBG
cord-001835-0s7ok4uw	5196	9	of	of	IN
cord-001835-0s7ok4uw	5196	10	tears	tear	NNS
cord-001835-0s7ok4uw	5196	11	in	in	IN
cord-001835-0s7ok4uw	5196	12	the	the	DT
cord-001835-0s7ok4uw	5196	13	sarcolemma	sarcolemma	NNP
cord-001835-0s7ok4uw	5196	14	of	of	IN
cord-001835-0s7ok4uw	5196	15	myofibers	myofibers	NNP
cord-001835-0s7ok4uw	5196	16	is	be	VBZ
cord-001835-0s7ok4uw	5196	17	a	a	DT
cord-001835-0s7ok4uw	5196	18	necessary	necessary	JJ
cord-001835-0s7ok4uw	5196	19	step	step	NN
cord-001835-0s7ok4uw	5196	20	in	in	IN
cord-001835-0s7ok4uw	5196	21	the	the	DT
cord-001835-0s7ok4uw	5196	22	repair	repair	NN
cord-001835-0s7ok4uw	5196	23	of	of	IN
cord-001835-0s7ok4uw	5196	24	muscle	muscle	NN
cord-001835-0s7ok4uw	5196	25	tissue	tissue	NN
cord-001835-0s7ok4uw	5196	26	.	.	.
cord-001835-0s7ok4uw	5197	1	Defects	defect	NNS
cord-001835-0s7ok4uw	5197	2	in	in	IN
cord-001835-0s7ok4uw	5197	3	this	this	DT
cord-001835-0s7ok4uw	5197	4	repair	repair	NN
cord-001835-0s7ok4uw	5197	5	process	process	NN
cord-001835-0s7ok4uw	5197	6	are	be	VBP
cord-001835-0s7ok4uw	5197	7	responsible	responsible	JJ
cord-001835-0s7ok4uw	5197	8	for	for	IN
cord-001835-0s7ok4uw	5197	9	muscular	muscular	JJ
cord-001835-0s7ok4uw	5197	10	dystrophy	dystrophy	NN
cord-001835-0s7ok4uw	5197	11	and	and	CC
cord-001835-0s7ok4uw	5197	12	cardiomyopathy	cardiomyopathy	NN
cord-001835-0s7ok4uw	5197	13	.	.	.
cord-001835-0s7ok4uw	5198	1	The	the	DT
cord-001835-0s7ok4uw	5198	2	repair	repair	NN
cord-001835-0s7ok4uw	5198	3	pathway	pathway	NN
cord-001835-0s7ok4uw	5198	4	is	be	VBZ
cord-001835-0s7ok4uw	5198	5	triggered	trigger	VBN
cord-001835-0s7ok4uw	5198	6	by	by	IN
cord-001835-0s7ok4uw	5198	7	the	the	DT
cord-001835-0s7ok4uw	5198	8	influx	influx	NN
cord-001835-0s7ok4uw	5198	9	of	of	IN
cord-001835-0s7ok4uw	5198	10	calcium	calcium	NN
cord-001835-0s7ok4uw	5198	11	through	through	IN
cord-001835-0s7ok4uw	5198	12	lesions	lesion	NNS
cord-001835-0s7ok4uw	5198	13	in	in	IN
cord-001835-0s7ok4uw	5198	14	the	the	DT
cord-001835-0s7ok4uw	5198	15	membrane	membrane	NN
cord-001835-0s7ok4uw	5198	16	,	,	,
cord-001835-0s7ok4uw	5198	17	which	which	WDT
cord-001835-0s7ok4uw	5198	18	result	result	VBP
cord-001835-0s7ok4uw	5198	19	in	in	IN
cord-001835-0s7ok4uw	5198	20	membrane	membrane	NN
cord-001835-0s7ok4uw	5198	21	fusion	fusion	NN
cord-001835-0s7ok4uw	5198	22	and	and	CC
cord-001835-0s7ok4uw	5198	23	patching	patching	NN
cord-001835-0s7ok4uw	5198	24	of	of	IN
cord-001835-0s7ok4uw	5198	25	the	the	DT
cord-001835-0s7ok4uw	5198	26	wound	wound	NN
cord-001835-0s7ok4uw	5198	27	.	.	.
cord-001835-0s7ok4uw	5199	1	Recently	recently	RB
cord-001835-0s7ok4uw	5199	2	dysferlin	dysferlin	NNP
cord-001835-0s7ok4uw	5199	3	has	have	VBZ
cord-001835-0s7ok4uw	5199	4	been	be	VBN
cord-001835-0s7ok4uw	5199	5	identified	identify	VBN
cord-001835-0s7ok4uw	5199	6	as	as	IN
cord-001835-0s7ok4uw	5199	7	a	a	DT
cord-001835-0s7ok4uw	5199	8	calcium	calcium	NN
cord-001835-0s7ok4uw	5199	9	binding	bind	VBG
cord-001835-0s7ok4uw	5199	10	protein	protein	NN
cord-001835-0s7ok4uw	5199	11	essential	essential	NN
cord-001835-0s7ok4uw	5199	12	for	for	IN
cord-001835-0s7ok4uw	5199	13	sarcolemma	sarcolemma	NNP
cord-001835-0s7ok4uw	5199	14	repair	repair	NNP
cord-001835-0s7ok4uw	5199	15	,	,	,
cord-001835-0s7ok4uw	5199	16	as	as	RB
cord-001835-0s7ok4uw	5199	17	well	well	RB
cord-001835-0s7ok4uw	5199	18	as	as	IN
cord-001835-0s7ok4uw	5199	19	other	other	JJ
cord-001835-0s7ok4uw	5199	20	SNARE	snare	NN
cord-001835-0s7ok4uw	5199	21	mediated	mediate	VBN
cord-001835-0s7ok4uw	5199	22	exocytotic	exocytotic	JJ
cord-001835-0s7ok4uw	5199	23	events	event	NNS
cord-001835-0s7ok4uw	5199	24	including	include	VBG
cord-001835-0s7ok4uw	5199	25	cytokine	cytokine	NN
cord-001835-0s7ok4uw	5199	26	and	and	CC
cord-001835-0s7ok4uw	5199	27	acid	acid	JJ
cord-001835-0s7ok4uw	5199	28	sphingomyelinase	sphingomyelinase	NN
cord-001835-0s7ok4uw	5199	29	secretion	secretion	NN
cord-001835-0s7ok4uw	5199	30	.	.	.
cord-001835-0s7ok4uw	5200	1	In	in	IN
cord-001835-0s7ok4uw	5200	2	this	this	DT
cord-001835-0s7ok4uw	5200	3	presentation	presentation	NN
cord-001835-0s7ok4uw	5200	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	5200	5	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	5200	6	a	a	DT
cord-001835-0s7ok4uw	5200	7	direct	direct	JJ
cord-001835-0s7ok4uw	5200	8	interaction	interaction	NN
cord-001835-0s7ok4uw	5200	9	between	between	IN
cord-001835-0s7ok4uw	5200	10	dysferlin	dysferlin	NNP
cord-001835-0s7ok4uw	5200	11	and	and	CC
cord-001835-0s7ok4uw	5200	12	the	the	DT
cord-001835-0s7ok4uw	5200	13	SNARE	snare	NN
cord-001835-0s7ok4uw	5200	14	proteins	protein	NNS
cord-001835-0s7ok4uw	5200	15	syntaxin	syntaxin	NNP
cord-001835-0s7ok4uw	5200	16	4	4	CD
cord-001835-0s7ok4uw	5200	17	and	and	CC
cord-001835-0s7ok4uw	5200	18	SNAP-23	SNAP-23	NNP
cord-001835-0s7ok4uw	5200	19	.	.	.
cord-001835-0s7ok4uw	5201	1	In	in	IN
cord-001835-0s7ok4uw	5201	2	addition	addition	NN
cord-001835-0s7ok4uw	5201	3	,	,	,
cord-001835-0s7ok4uw	5201	4	FRET	fret	NN
cord-001835-0s7ok4uw	5201	5	and	and	CC
cord-001835-0s7ok4uw	5201	6	in	in	IN
cord-001835-0s7ok4uw	5201	7	vitro	vitro	FW
cord-001835-0s7ok4uw	5201	8	reconstituted	reconstitute	VBN
cord-001835-0s7ok4uw	5201	9	lipid	lipid	NN
cord-001835-0s7ok4uw	5201	10	mixing	mix	VBG
cord-001835-0s7ok4uw	5201	11	assays	assay	NNS
cord-001835-0s7ok4uw	5201	12	indicate	indicate	VBP
cord-001835-0s7ok4uw	5201	13	that	that	IN
cord-001835-0s7ok4uw	5201	14	dysferlin	dysferlin	NNP
cord-001835-0s7ok4uw	5201	15	accelerates	accelerate	VBZ
cord-001835-0s7ok4uw	5201	16	SNARE	SNARE	NNP
cord-001835-0s7ok4uw	5201	17	heterodimer	heterodimer	NN
cord-001835-0s7ok4uw	5201	18	formation	formation	NN
cord-001835-0s7ok4uw	5201	19	and	and	CC
cord-001835-0s7ok4uw	5201	20	SNARE	snare	VB
cord-001835-0s7ok4uw	5201	21	mediated	mediate	VBN
cord-001835-0s7ok4uw	5201	22	lipid	lipid	NN
cord-001835-0s7ok4uw	5201	23	mixing	mix	VBG
cord-001835-0s7ok4uw	5201	24	in	in	IN
cord-001835-0s7ok4uw	5201	25	a	a	DT
cord-001835-0s7ok4uw	5201	26	calcium	calcium	NN
cord-001835-0s7ok4uw	5201	27	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	5201	28	manner	manner	NN
cord-001835-0s7ok4uw	5201	29	.	.	.
cord-001835-0s7ok4uw	5202	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	5202	2	results	result	NNS
cord-001835-0s7ok4uw	5202	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	5202	4	a	a	DT
cord-001835-0s7ok4uw	5202	5	model	model	NN
cord-001835-0s7ok4uw	5202	6	whereby	whereby	WRB
cord-001835-0s7ok4uw	5202	7	dysferlin	dysferlin	NNP
cord-001835-0s7ok4uw	5202	8	acts	act	VBZ
cord-001835-0s7ok4uw	5202	9	as	as	IN
cord-001835-0s7ok4uw	5202	10	a	a	DT
cord-001835-0s7ok4uw	5202	11	calcium	calcium	NN
cord-001835-0s7ok4uw	5202	12	sensing	sensing	NN
cord-001835-0s7ok4uw	5202	13	SNARE	snare	VB
cord-001835-0s7ok4uw	5202	14	effector	effector	NN
cord-001835-0s7ok4uw	5202	15	for	for	IN
cord-001835-0s7ok4uw	5202	16	exocytosis	exocytosis	NN
cord-001835-0s7ok4uw	5202	17	and	and	CC
cord-001835-0s7ok4uw	5202	18	membrane	membrane	NN
cord-001835-0s7ok4uw	5202	19	fusion	fusion	NN
cord-001835-0s7ok4uw	5202	20	.	.	.
cord-001835-0s7ok4uw	5203	1	Exploring	explore	VBG
cord-001835-0s7ok4uw	5203	2	the	the	DT
cord-001835-0s7ok4uw	5203	3	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	5203	4	potential	potential	NN
cord-001835-0s7ok4uw	5203	5	of	of	IN
cord-001835-0s7ok4uw	5203	6	a	a	DT
cord-001835-0s7ok4uw	5203	7	peptide	peptide	NN
cord-001835-0s7ok4uw	5203	8	derived	derive	VBN
cord-001835-0s7ok4uw	5203	9	from	from	IN
cord-001835-0s7ok4uw	5203	10	a	a	DT
cord-001835-0s7ok4uw	5203	11	poxviral	poxviral	JJ
cord-001835-0s7ok4uw	5203	12	immune	immune	JJ
cord-001835-0s7ok4uw	5203	13	evasion	evasion	NN
cord-001835-0s7ok4uw	5203	14	protein	protein	NN
cord-001835-0s7ok4uw	5203	15	:	:	:
cord-001835-0s7ok4uw	5203	16	NMR	NMR	NNP
cord-001835-0s7ok4uw	5203	17	determination	determination	NN
cord-001835-0s7ok4uw	5203	18	of	of	IN
cord-001835-0s7ok4uw	5203	19	the	the	DT
cord-001835-0s7ok4uw	5203	20	solution	solution	NN
cord-001835-0s7ok4uw	5203	21	structure	structure	NN
cord-001835-0s7ok4uw	5203	22	of	of	IN
cord-001835-0s7ok4uw	5203	23	VIPER	VIPER	NNP
cord-001835-0s7ok4uw	5203	24	and	and	CC
cord-001835-0s7ok4uw	5203	25	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5203	26	inactive	inactive	JJ
cord-001835-0s7ok4uw	5203	27	mutant	mutant	JJ
cord-001835-0s7ok4uw	5203	28	Toll	toll	NN
cord-001835-0s7ok4uw	5203	29	-	-	HYPH
cord-001835-0s7ok4uw	5203	30	like	like	JJ
cord-001835-0s7ok4uw	5203	31	receptors	receptor	NNS
cord-001835-0s7ok4uw	5203	32	(	(	-LRB-
cord-001835-0s7ok4uw	5203	33	TLRs	TLRs	NNP
cord-001835-0s7ok4uw	5203	34	)	)	-RRB-
cord-001835-0s7ok4uw	5203	35	have	have	VBP
cord-001835-0s7ok4uw	5203	36	a	a	DT
cord-001835-0s7ok4uw	5203	37	role	role	NN
cord-001835-0s7ok4uw	5203	38	in	in	IN
cord-001835-0s7ok4uw	5203	39	viral	viral	JJ
cord-001835-0s7ok4uw	5203	40	detection	detection	NN
cord-001835-0s7ok4uw	5203	41	leading	lead	VBG
cord-001835-0s7ok4uw	5203	42	to	to	IN
cord-001835-0s7ok4uw	5203	43	cytokine	cytokine	NN
cord-001835-0s7ok4uw	5203	44	and	and	CC
cord-001835-0s7ok4uw	5203	45	IFN	IFN	NNP
cord-001835-0s7ok4uw	5203	46	induction	induction	NN
cord-001835-0s7ok4uw	5203	47	,	,	,
cord-001835-0s7ok4uw	5203	48	and	and	CC
cord-001835-0s7ok4uw	5203	49	as	as	RB
cord-001835-0s7ok4uw	5203	50	such	such	JJ
cord-001835-0s7ok4uw	5203	51	they	-PRON-	PRP
cord-001835-0s7ok4uw	5203	52	are	be	VBP
cord-001835-0s7ok4uw	5203	53	targeted	target	VBN
cord-001835-0s7ok4uw	5203	54	by	by	IN
cord-001835-0s7ok4uw	5203	55	viruses	virus	NNS
cord-001835-0s7ok4uw	5203	56	for	for	IN
cord-001835-0s7ok4uw	5203	57	immune	immune	JJ
cord-001835-0s7ok4uw	5203	58	evasion	evasion	NN
cord-001835-0s7ok4uw	5203	59	.	.	.
cord-001835-0s7ok4uw	5204	1	The	the	DT
cord-001835-0s7ok4uw	5204	2	poxviral	poxviral	JJ
cord-001835-0s7ok4uw	5204	3	protein	protein	NN
cord-001835-0s7ok4uw	5204	4	A46	A46	NNP
cord-001835-0s7ok4uw	5204	5	has	have	VBZ
cord-001835-0s7ok4uw	5204	6	been	be	VBN
cord-001835-0s7ok4uw	5204	7	identified	identify	VBN
cord-001835-0s7ok4uw	5204	8	to	to	TO
cord-001835-0s7ok4uw	5204	9	inhibit	inhibit	VB
cord-001835-0s7ok4uw	5204	10	TLR	TLR	NNP
cord-001835-0s7ok4uw	5204	11	signaling	signal	VBG
cord-001835-0s7ok4uw	5204	12	by	by	IN
cord-001835-0s7ok4uw	5204	13	interacting	interact	VBG
cord-001835-0s7ok4uw	5204	14	with	with	IN
cord-001835-0s7ok4uw	5204	15	TIR	TIR	NNP
cord-001835-0s7ok4uw	5204	16	domain	domain	NN
cord-001835-0s7ok4uw	5204	17	-	-	HYPH
cord-001835-0s7ok4uw	5204	18	containing	contain	VBG
cord-001835-0s7ok4uw	5204	19	proteins	protein	NNS
cord-001835-0s7ok4uw	5204	20	of	of	IN
cord-001835-0s7ok4uw	5204	21	the	the	DT
cord-001835-0s7ok4uw	5204	22	receptor	receptor	NN
cord-001835-0s7ok4uw	5204	23	complex	complex	NN
cord-001835-0s7ok4uw	5204	24	to	to	TO
cord-001835-0s7ok4uw	5204	25	collectively	collectively	RB
cord-001835-0s7ok4uw	5204	26	inhibit	inhibit	VB
cord-001835-0s7ok4uw	5204	27	all	all	DT
cord-001835-0s7ok4uw	5204	28	TLR	TLR	NNP
cord-001835-0s7ok4uw	5204	29	adaptor	adaptor	NN
cord-001835-0s7ok4uw	5204	30	proteins	protein	NNS
cord-001835-0s7ok4uw	5204	31	that	that	WDT
cord-001835-0s7ok4uw	5204	32	positively	positively	RB
cord-001835-0s7ok4uw	5204	33	regulate	regulate	VBP
cord-001835-0s7ok4uw	5204	34	transcription	transcription	NN
cord-001835-0s7ok4uw	5204	35	-	-	HYPH
cord-001835-0s7ok4uw	5204	36	factor	factor	NN
cord-001835-0s7ok4uw	5204	37	activation	activation	NN
cord-001835-0s7ok4uw	5204	38	(	(	-LRB-
cord-001835-0s7ok4uw	5204	39	1	1	CD
cord-001835-0s7ok4uw	5204	40	)	)	-RRB-
cord-001835-0s7ok4uw	5204	41	.	.	.
cord-001835-0s7ok4uw	5205	1	One	one	CD
cord-001835-0s7ok4uw	5205	2	11	11	CD
cord-001835-0s7ok4uw	5205	3	aa	aa	NNP
cord-001835-0s7ok4uw	5205	4	peptide	peptide	NN
cord-001835-0s7ok4uw	5205	5	(	(	-LRB-
cord-001835-0s7ok4uw	5205	6	KYSF	KYSF	NNP
cord-001835-0s7ok4uw	5205	7	-	-	HYPH
cord-001835-0s7ok4uw	5205	8	KLILAEY	KLILAEY	NNP
cord-001835-0s7ok4uw	5205	9	)	)	-RRB-
cord-001835-0s7ok4uw	5205	10	termed	term	VBN
cord-001835-0s7ok4uw	5205	11	VIPER	viper	NN
cord-001835-0s7ok4uw	5205	12	(	(	-LRB-
cord-001835-0s7ok4uw	5205	13	Viral	Viral	NNP
cord-001835-0s7ok4uw	5205	14	Inhibitory	Inhibitory	NNP
cord-001835-0s7ok4uw	5205	15	Peptide	Peptide	NNP
cord-001835-0s7ok4uw	5205	16	of	of	IN
cord-001835-0s7ok4uw	5205	17	TLR4	TLR4	NNP
cord-001835-0s7ok4uw	5205	18	)	)	-RRB-
cord-001835-0s7ok4uw	5205	19	was	be	VBD
cord-001835-0s7ok4uw	5205	20	reported	report	VBN
cord-001835-0s7ok4uw	5205	21	to	to	TO
cord-001835-0s7ok4uw	5205	22	retain	retain	VB
cord-001835-0s7ok4uw	5205	23	the	the	DT
cord-001835-0s7ok4uw	5205	24	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	5205	25	properties	property	NNS
cord-001835-0s7ok4uw	5205	26	of	of	IN
cord-001835-0s7ok4uw	5205	27	full	full	JJ
cord-001835-0s7ok4uw	5205	28	length	length	NN
cord-001835-0s7ok4uw	5205	29	A46	A46	NNP
cord-001835-0s7ok4uw	5205	30	against	against	IN
cord-001835-0s7ok4uw	5205	31	TLR4	TLR4	NNP
cord-001835-0s7ok4uw	5205	32	signaling	signaling	NN
cord-001835-0s7ok4uw	5205	33	.	.	.
cord-001835-0s7ok4uw	5206	1	A	a	DT
cord-001835-0s7ok4uw	5206	2	9R	9r	CD
cord-001835-0s7ok4uw	5206	3	homopolymer	homopolymer	NN
cord-001835-0s7ok4uw	5206	4	delivery	delivery	NN
cord-001835-0s7ok4uw	5206	5	sequence	sequence	NN
cord-001835-0s7ok4uw	5206	6	at	at	IN
cord-001835-0s7ok4uw	5206	7	the	the	DT
cord-001835-0s7ok4uw	5206	8	C	C	NNP
cord-001835-0s7ok4uw	5206	9	-	-	HYPH
cord-001835-0s7ok4uw	5206	10	terminus	terminus	NN
cord-001835-0s7ok4uw	5206	11	provided	provide	VBN
cord-001835-0s7ok4uw	5206	12	delivery	delivery	NN
cord-001835-0s7ok4uw	5206	13	of	of	IN
cord-001835-0s7ok4uw	5206	14	the	the	DT
cord-001835-0s7ok4uw	5206	15	peptide	peptide	NN
cord-001835-0s7ok4uw	5206	16	into	into	IN
cord-001835-0s7ok4uw	5206	17	cells	cell	NNS
cord-001835-0s7ok4uw	5206	18	.	.	.
cord-001835-0s7ok4uw	5207	1	Structural	structural	JJ
cord-001835-0s7ok4uw	5207	2	comparisons	comparison	NNS
cord-001835-0s7ok4uw	5207	3	are	be	VBP
cord-001835-0s7ok4uw	5207	4	presented	present	VBN
cord-001835-0s7ok4uw	5207	5	between	between	IN
cord-001835-0s7ok4uw	5207	6	9R	9r	CD
cord-001835-0s7ok4uw	5207	7	-	-	HYPH
cord-001835-0s7ok4uw	5207	8	VIPER	VIPER	NNP
cord-001835-0s7ok4uw	5207	9	,	,	,
cord-001835-0s7ok4uw	5207	10	which	which	WDT
cord-001835-0s7ok4uw	5207	11	is	be	VBZ
cord-001835-0s7ok4uw	5207	12	active	active	JJ
cord-001835-0s7ok4uw	5207	13	in	in	IN
cord-001835-0s7ok4uw	5207	14	preventing	prevent	VBG
cord-001835-0s7ok4uw	5207	15	TLR4-dependent	tlr4-dependent	NN
cord-001835-0s7ok4uw	5207	16	cytokine	cytokine	NN
cord-001835-0s7ok4uw	5207	17	induction	induction	NN
cord-001835-0s7ok4uw	5207	18	in	in	IN
cord-001835-0s7ok4uw	5207	19	cell	cell	NN
cord-001835-0s7ok4uw	5207	20	culture	culture	NN
cord-001835-0s7ok4uw	5207	21	,	,	,
cord-001835-0s7ok4uw	5207	22	and	and	CC
cord-001835-0s7ok4uw	5207	23	a	a	DT
cord-001835-0s7ok4uw	5207	24	mutant	mutant	NN
cord-001835-0s7ok4uw	5207	25	that	that	WDT
cord-001835-0s7ok4uw	5207	26	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	5207	27	loss	loss	NN
cord-001835-0s7ok4uw	5207	28	of	of	IN
cord-001835-0s7ok4uw	5207	29	function	function	NN
cord-001835-0s7ok4uw	5207	30	(	(	-LRB-
cord-001835-0s7ok4uw	5207	31	9R	9r	CD
cord-001835-0s7ok4uw	5207	32	-	-	HYPH
cord-001835-0s7ok4uw	5207	33	VIPER	VIPER	NNP
cord-001835-0s7ok4uw	5207	34	L6A	l6a	NN
cord-001835-0s7ok4uw	5207	35	,	,	,
cord-001835-0s7ok4uw	5207	36	E10A	E10A	NNP
cord-001835-0s7ok4uw	5207	37	)	)	-RRB-
cord-001835-0s7ok4uw	5207	38	,	,	,
cord-001835-0s7ok4uw	5207	39	through	through	IN
cord-001835-0s7ok4uw	5207	40	solution	solution	NN
cord-001835-0s7ok4uw	5207	41	NMR	nmr	NN
cord-001835-0s7ok4uw	5207	42	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	5207	43	.	.	.
cord-001835-0s7ok4uw	5208	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5208	2	find	find	VBP
cord-001835-0s7ok4uw	5208	3	that	that	IN
cord-001835-0s7ok4uw	5208	4	despite	despite	IN
cord-001835-0s7ok4uw	5208	5	a	a	DT
cord-001835-0s7ok4uw	5208	6	relatively	relatively	RB
cord-001835-0s7ok4uw	5208	7	minor	minor	JJ
cord-001835-0s7ok4uw	5208	8	sequence	sequence	NN
cord-001835-0s7ok4uw	5208	9	difference	difference	NN
cord-001835-0s7ok4uw	5208	10	,	,	,
cord-001835-0s7ok4uw	5208	11	the	the	DT
cord-001835-0s7ok4uw	5208	12	loss	loss	NN
cord-001835-0s7ok4uw	5208	13	of	of	IN
cord-001835-0s7ok4uw	5208	14	hydrophobicity	hydrophobicity	NN
cord-001835-0s7ok4uw	5208	15	as	as	RB
cord-001835-0s7ok4uw	5208	16	well	well	RB
cord-001835-0s7ok4uw	5208	17	as	as	IN
cord-001835-0s7ok4uw	5208	18	negative	negative	JJ
cord-001835-0s7ok4uw	5208	19	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	5208	20	interactions	interaction	NNS
cord-001835-0s7ok4uw	5208	21	result	result	VBP
cord-001835-0s7ok4uw	5208	22	in	in	IN
cord-001835-0s7ok4uw	5208	23	subtle	subtle	JJ
cord-001835-0s7ok4uw	5208	24	but	but	CC
cord-001835-0s7ok4uw	5208	25	potentially	potentially	RB
cord-001835-0s7ok4uw	5208	26	significant	significant	JJ
cord-001835-0s7ok4uw	5208	27	differences	difference	NNS
cord-001835-0s7ok4uw	5208	28	in	in	IN
cord-001835-0s7ok4uw	5208	29	the	the	DT
cord-001835-0s7ok4uw	5208	30	region	region	NN
cord-001835-0s7ok4uw	5208	31	of	of	IN
cord-001835-0s7ok4uw	5208	32	the	the	DT
cord-001835-0s7ok4uw	5208	33	peptide	peptide	NN
cord-001835-0s7ok4uw	5208	34	proposed	propose	VBD
cord-001835-0s7ok4uw	5208	35	to	to	TO
cord-001835-0s7ok4uw	5208	36	interface	interface	VB
cord-001835-0s7ok4uw	5208	37	with	with	IN
cord-001835-0s7ok4uw	5208	38	TLR4	TLR4	NNP
cord-001835-0s7ok4uw	5208	39	.	.	.
cord-001835-0s7ok4uw	5209	1	Reference	reference	NN
cord-001835-0s7ok4uw	5209	2	:	:	:
cord-001835-0s7ok4uw	5210	1	Wake	Wake	NNP
cord-001835-0s7ok4uw	5210	2	Forest	Forest	NNP
cord-001835-0s7ok4uw	5210	3	University	University	NNP
cord-001835-0s7ok4uw	5210	4	,	,	,
cord-001835-0s7ok4uw	5210	5	2	2	CD
cord-001835-0s7ok4uw	5210	6	Wake	Wake	NNP
cord-001835-0s7ok4uw	5210	7	Forest	Forest	NNP
cord-001835-0s7ok4uw	5210	8	University	University	NNP
cord-001835-0s7ok4uw	5210	9	,	,	,
cord-001835-0s7ok4uw	5210	10	3	3	CD
cord-001835-0s7ok4uw	5210	11	University	University	NNP
cord-001835-0s7ok4uw	5210	12	of	of	IN
cord-001835-0s7ok4uw	5210	13	California	California	NNP
cord-001835-0s7ok4uw	5210	14	San	San	NNP
cord-001835-0s7ok4uw	5210	15	Francisco	Francisco	NNP
cord-001835-0s7ok4uw	5210	16	Protein	Protein	NNP
cord-001835-0s7ok4uw	5210	17	Function	Function	NNP
cord-001835-0s7ok4uw	5210	18	Prediction	Prediction	NNP
cord-001835-0s7ok4uw	5211	1	The	the	DT
cord-001835-0s7ok4uw	5211	2	elucidation	elucidation	NN
cord-001835-0s7ok4uw	5211	3	of	of	IN
cord-001835-0s7ok4uw	5211	4	protein	protein	NN
cord-001835-0s7ok4uw	5211	5	molecular	molecular	JJ
cord-001835-0s7ok4uw	5211	6	function	function	NN
cord-001835-0s7ok4uw	5211	7	lags	lag	VBZ
cord-001835-0s7ok4uw	5211	8	far	far	RB
cord-001835-0s7ok4uw	5211	9	behind	behind	IN
cord-001835-0s7ok4uw	5211	10	the	the	DT
cord-001835-0s7ok4uw	5211	11	rate	rate	NN
cord-001835-0s7ok4uw	5211	12	of	of	IN
cord-001835-0s7ok4uw	5211	13	highthroughput	highthroughput	NN
cord-001835-0s7ok4uw	5211	14	sequencing	sequencing	NN
cord-001835-0s7ok4uw	5211	15	technology	technology	NN
cord-001835-0s7ok4uw	5211	16	;	;	:
cord-001835-0s7ok4uw	5211	17	thus	thus	RB
cord-001835-0s7ok4uw	5211	18	,	,	,
cord-001835-0s7ok4uw	5211	19	it	-PRON-	PRP
cord-001835-0s7ok4uw	5211	20	is	be	VBZ
cord-001835-0s7ok4uw	5211	21	essential	essential	JJ
cord-001835-0s7ok4uw	5211	22	to	to	TO
cord-001835-0s7ok4uw	5211	23	develop	develop	VB
cord-001835-0s7ok4uw	5211	24	accurate	accurate	JJ
cord-001835-0s7ok4uw	5211	25	and	and	CC
cord-001835-0s7ok4uw	5211	26	efficient	efficient	JJ
cord-001835-0s7ok4uw	5211	27	computational	computational	JJ
cord-001835-0s7ok4uw	5211	28	methods	method	NNS
cord-001835-0s7ok4uw	5211	29	to	to	TO
cord-001835-0s7ok4uw	5211	30	define	define	VB
cord-001835-0s7ok4uw	5211	31	functional	functional	JJ
cord-001835-0s7ok4uw	5211	32	relationships	relationship	NNS
cord-001835-0s7ok4uw	5211	33	.	.	.
cord-001835-0s7ok4uw	5212	1	Protein	protein	NN
cord-001835-0s7ok4uw	5212	2	clustering	clustering	NN
cord-001835-0s7ok4uw	5212	3	based	base	VBN
cord-001835-0s7ok4uw	5212	4	on	on	IN
cord-001835-0s7ok4uw	5212	5	sequence	sequence	NN
cord-001835-0s7ok4uw	5212	6	similarity	similarity	NN
cord-001835-0s7ok4uw	5212	7	has	have	VBZ
cord-001835-0s7ok4uw	5212	8	emerged	emerge	VBN
cord-001835-0s7ok4uw	5212	9	as	as	IN
cord-001835-0s7ok4uw	5212	10	a	a	DT
cord-001835-0s7ok4uw	5212	11	simple	simple	JJ
cord-001835-0s7ok4uw	5212	12	,	,	,
cord-001835-0s7ok4uw	5212	13	high	high	JJ
cord-001835-0s7ok4uw	5212	14	-	-	HYPH
cord-001835-0s7ok4uw	5212	15	throughput	throughput	NN
cord-001835-0s7ok4uw	5212	16	method	method	NN
cord-001835-0s7ok4uw	5212	17	for	for	IN
cord-001835-0s7ok4uw	5212	18	defining	define	VBG
cord-001835-0s7ok4uw	5212	19	protein	protein	NN
cord-001835-0s7ok4uw	5212	20	relationships	relationship	NNS
cord-001835-0s7ok4uw	5212	21	,	,	,
cord-001835-0s7ok4uw	5212	22	but	but	CC
cord-001835-0s7ok4uw	5212	23	sequence	sequence	NN
cord-001835-0s7ok4uw	5212	24	-	-	HYPH
cord-001835-0s7ok4uw	5212	25	based	base	VBN
cord-001835-0s7ok4uw	5212	26	techniques	technique	NNS
cord-001835-0s7ok4uw	5212	27	often	often	RB
cord-001835-0s7ok4uw	5212	28	inaccurately	inaccurately	RB
cord-001835-0s7ok4uw	5212	29	define	define	VBP
cord-001835-0s7ok4uw	5212	30	molecular	molecular	JJ
cord-001835-0s7ok4uw	5212	31	function	function	NN
cord-001835-0s7ok4uw	5212	32	details	detail	NNS
cord-001835-0s7ok4uw	5212	33	.	.	.
cord-001835-0s7ok4uw	5213	1	Active	active	JJ
cord-001835-0s7ok4uw	5213	2	site	site	NN
cord-001835-0s7ok4uw	5213	3	profiling	profiling	NN
cord-001835-0s7ok4uw	5213	4	(	(	-LRB-
cord-001835-0s7ok4uw	5213	5	ASP	ASP	NNP
cord-001835-0s7ok4uw	5213	6	)	)	-RRB-
cord-001835-0s7ok4uw	5213	7	was	be	VBD
cord-001835-0s7ok4uw	5213	8	previously	previously	RB
cord-001835-0s7ok4uw	5213	9	developed	develop	VBN
cord-001835-0s7ok4uw	5213	10	to	to	TO
cord-001835-0s7ok4uw	5213	11	identify	identify	VB
cord-001835-0s7ok4uw	5213	12	and	and	CC
cord-001835-0s7ok4uw	5213	13	compare	compare	VB
cord-001835-0s7ok4uw	5213	14	molecular	molecular	JJ
cord-001835-0s7ok4uw	5213	15	details	detail	NNS
cord-001835-0s7ok4uw	5213	16	of	of	IN
cord-001835-0s7ok4uw	5213	17	protein	protein	NN
cord-001835-0s7ok4uw	5213	18	functional	functional	JJ
cord-001835-0s7ok4uw	5213	19	sites	site	NNS
cord-001835-0s7ok4uw	5213	20	.	.	.
cord-001835-0s7ok4uw	5214	1	Protein	protein	NN
cord-001835-0s7ok4uw	5214	2	similarity	similarity	NN
cord-001835-0s7ok4uw	5214	3	networks	network	NNS
cord-001835-0s7ok4uw	5214	4	were	be	VBD
cord-001835-0s7ok4uw	5214	5	created	create	VBN
cord-001835-0s7ok4uw	5214	6	using	use	VBG
cord-001835-0s7ok4uw	5214	7	both	both	DT
cord-001835-0s7ok4uw	5214	8	active	active	JJ
cord-001835-0s7ok4uw	5214	9	site	site	NN
cord-001835-0s7ok4uw	5214	10	similarity	similarity	NN
cord-001835-0s7ok4uw	5214	11	and	and	CC
cord-001835-0s7ok4uw	5214	12	sequence	sequence	NN
cord-001835-0s7ok4uw	5214	13	similarity	similarity	NN
cord-001835-0s7ok4uw	5214	14	for	for	IN
cord-001835-0s7ok4uw	5214	15	four	four	CD
cord-001835-0s7ok4uw	5214	16	manually	manually	RB
cord-001835-0s7ok4uw	5214	17	curated	curate	VBN
cord-001835-0s7ok4uw	5214	18	superfamilies	superfamily	NNS
cord-001835-0s7ok4uw	5214	19	,	,	,
cord-001835-0s7ok4uw	5214	20	and	and	CC
cord-001835-0s7ok4uw	5214	21	results	result	NNS
cord-001835-0s7ok4uw	5214	22	demonstrate	demonstrate	VBP
cord-001835-0s7ok4uw	5214	23	that	that	IN
cord-001835-0s7ok4uw	5214	24	ASP	asp	NN
cord-001835-0s7ok4uw	5214	25	-	-	HYPH
cord-001835-0s7ok4uw	5214	26	based	base	VBN
cord-001835-0s7ok4uw	5214	27	clustering	clustering	NN
cord-001835-0s7ok4uw	5214	28	identifies	identify	VBZ
cord-001835-0s7ok4uw	5214	29	detailed	detailed	JJ
cord-001835-0s7ok4uw	5214	30	functional	functional	JJ
cord-001835-0s7ok4uw	5214	31	relationships	relationship	NNS
cord-001835-0s7ok4uw	5214	32	more	more	RBR
cord-001835-0s7ok4uw	5214	33	accurately	accurately	RB
cord-001835-0s7ok4uw	5214	34	than	than	IN
cord-001835-0s7ok4uw	5214	35	sequence	sequence	NN
cord-001835-0s7ok4uw	5214	36	-	-	HYPH
cord-001835-0s7ok4uw	5214	37	based	base	VBN
cord-001835-0s7ok4uw	5214	38	clustering	clustering	NN
cord-001835-0s7ok4uw	5214	39	.	.	.
cord-001835-0s7ok4uw	5215	1	Building	build	VBG
cord-001835-0s7ok4uw	5215	2	on	on	IN
cord-001835-0s7ok4uw	5215	3	this	this	DT
cord-001835-0s7ok4uw	5215	4	,	,	,
cord-001835-0s7ok4uw	5215	5	two	two	CD
cord-001835-0s7ok4uw	5215	6	iterative	iterative	JJ
cord-001835-0s7ok4uw	5215	7	pipelines	pipeline	NNS
cord-001835-0s7ok4uw	5215	8	were	be	VBD
cord-001835-0s7ok4uw	5215	9	developed	develop	VBN
cord-001835-0s7ok4uw	5215	10	using	use	VBG
cord-001835-0s7ok4uw	5215	11	active	active	JJ
cord-001835-0s7ok4uw	5215	12	site	site	NN
cord-001835-0s7ok4uw	5215	13	profiling	profiling	NN
cord-001835-0s7ok4uw	5215	14	and	and	CC
cord-001835-0s7ok4uw	5215	15	profile	profile	NN
cord-001835-0s7ok4uw	5215	16	-	-	HYPH
cord-001835-0s7ok4uw	5215	17	based	base	VBN
cord-001835-0s7ok4uw	5215	18	searches	search	NNS
cord-001835-0s7ok4uw	5215	19	to	to	TO
cord-001835-0s7ok4uw	5215	20	cluster	cluster	VB
cord-001835-0s7ok4uw	5215	21	protein	protein	NN
cord-001835-0s7ok4uw	5215	22	superfamilies	superfamily	NNS
cord-001835-0s7ok4uw	5215	23	into	into	IN
cord-001835-0s7ok4uw	5215	24	functional	functional	JJ
cord-001835-0s7ok4uw	5215	25	groups	group	NNS
cord-001835-0s7ok4uw	5215	26	.	.	.
cord-001835-0s7ok4uw	5216	1	First	first	RB
cord-001835-0s7ok4uw	5216	2	,	,	,
cord-001835-0s7ok4uw	5216	3	the	the	DT
cord-001835-0s7ok4uw	5216	4	Two	two	CD
cord-001835-0s7ok4uw	5216	5	Level	Level	NNP
cord-001835-0s7ok4uw	5216	6	Iterative	iterative	JJ
cord-001835-0s7ok4uw	5216	7	clustering	clustering	NN
cord-001835-0s7ok4uw	5216	8	Process	process	NN
cord-001835-0s7ok4uw	5216	9	(	(	-LRB-
cord-001835-0s7ok4uw	5216	10	TuLIP	TuLIP	NNP
cord-001835-0s7ok4uw	5216	11	)	)	-RRB-
cord-001835-0s7ok4uw	5216	12	utilizes	utilize	VBZ
cord-001835-0s7ok4uw	5216	13	active	active	JJ
cord-001835-0s7ok4uw	5216	14	site	site	NN
cord-001835-0s7ok4uw	5216	15	profiling	profiling	NN
cord-001835-0s7ok4uw	5216	16	and	and	CC
cord-001835-0s7ok4uw	5216	17	iterative	iterative	JJ
cord-001835-0s7ok4uw	5216	18	PDB	PDB	NNP
cord-001835-0s7ok4uw	5216	19	searches	search	VBZ
cord-001835-0s7ok4uw	5216	20	to	to	TO
cord-001835-0s7ok4uw	5216	21	divisively	divisively	RB
cord-001835-0s7ok4uw	5216	22	cluster	cluster	JJ
cord-001835-0s7ok4uw	5216	23	protein	protein	NN
cord-001835-0s7ok4uw	5216	24	structures	structure	NNS
cord-001835-0s7ok4uw	5216	25	into	into	IN
cord-001835-0s7ok4uw	5216	26	groups	group	NNS
cord-001835-0s7ok4uw	5216	27	that	that	WDT
cord-001835-0s7ok4uw	5216	28	share	share	VBP
cord-001835-0s7ok4uw	5216	29	functional	functional	JJ
cord-001835-0s7ok4uw	5216	30	site	site	NN
cord-001835-0s7ok4uw	5216	31	features	feature	NNS
cord-001835-0s7ok4uw	5216	32	.	.	.
cord-001835-0s7ok4uw	5217	1	Across	across	IN
cord-001835-0s7ok4uw	5217	2	eight	eight	CD
cord-001835-0s7ok4uw	5217	3	superfamilies	superfamily	NNS
cord-001835-0s7ok4uw	5217	4	,	,	,
cord-001835-0s7ok4uw	5217	5	TuLIP	TuLIP	NNP
cord-001835-0s7ok4uw	5217	6	clusters	cluster	NNS
cord-001835-0s7ok4uw	5217	7	exhibit	exhibit	VBP
cord-001835-0s7ok4uw	5217	8	high	high	JJ
cord-001835-0s7ok4uw	5217	9	correlation	correlation	NN
cord-001835-0s7ok4uw	5217	10	with	with	IN
cord-001835-0s7ok4uw	5217	11	expert	expert	JJ
cord-001835-0s7ok4uw	5217	12	functional	functional	JJ
cord-001835-0s7ok4uw	5217	13	annotations	annotation	NNS
cord-001835-0s7ok4uw	5217	14	.	.	.
cord-001835-0s7ok4uw	5218	1	Subsequently	subsequently	RB
cord-001835-0s7ok4uw	5218	2	,	,	,
cord-001835-0s7ok4uw	5218	3	the	the	DT
cord-001835-0s7ok4uw	5218	4	Multi	multi	JJ
cord-001835-0s7ok4uw	5218	5	-	-	JJ
cord-001835-0s7ok4uw	5218	6	level	level	JJ
cord-001835-0s7ok4uw	5218	7	Iterative	iterative	JJ
cord-001835-0s7ok4uw	5218	8	Sequence	sequence	NN
cord-001835-0s7ok4uw	5218	9	Searching	Searching	NNP
cord-001835-0s7ok4uw	5218	10	Technique	technique	NN
cord-001835-0s7ok4uw	5218	11	(	(	-LRB-
cord-001835-0s7ok4uw	5218	12	MISST	MISST	NNP
cord-001835-0s7ok4uw	5218	13	)	)	-RRB-
cord-001835-0s7ok4uw	5218	14	utilizes	utilize	VBZ
cord-001835-0s7ok4uw	5218	15	iterative	iterative	JJ
cord-001835-0s7ok4uw	5218	16	profile	profile	NN
cord-001835-0s7ok4uw	5218	17	-	-	HYPH
cord-001835-0s7ok4uw	5218	18	based	base	VBN
cord-001835-0s7ok4uw	5218	19	GenBank	GenBank	NNP
cord-001835-0s7ok4uw	5218	20	searches	search	NNS
cord-001835-0s7ok4uw	5218	21	to	to	TO
cord-001835-0s7ok4uw	5218	22	identify	identify	VB
cord-001835-0s7ok4uw	5218	23	protein	protein	NN
cord-001835-0s7ok4uw	5218	24	sequences	sequence	NNS
cord-001835-0s7ok4uw	5218	25	that	that	WDT
cord-001835-0s7ok4uw	5218	26	belong	belong	VBP
cord-001835-0s7ok4uw	5218	27	in	in	IN
cord-001835-0s7ok4uw	5218	28	each	each	DT
cord-001835-0s7ok4uw	5218	29	TuLIP	TuLIP	NNP
cord-001835-0s7ok4uw	5218	30	group	group	NN
cord-001835-0s7ok4uw	5218	31	.	.	.
cord-001835-0s7ok4uw	5219	1	The	the	DT
cord-001835-0s7ok4uw	5219	2	results	result	NNS
cord-001835-0s7ok4uw	5219	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	5219	4	that	that	IN
cord-001835-0s7ok4uw	5219	5	these	these	DT
cord-001835-0s7ok4uw	5219	6	ASP	ASP	NNP
cord-001835-0s7ok4uw	5219	7	-	-	HYPH
cord-001835-0s7ok4uw	5219	8	based	base	VBN
cord-001835-0s7ok4uw	5219	9	methods	method	NNS
cord-001835-0s7ok4uw	5219	10	accurately	accurately	RB
cord-001835-0s7ok4uw	5219	11	and	and	CC
cord-001835-0s7ok4uw	5219	12	efficiently	efficiently	RB
cord-001835-0s7ok4uw	5219	13	identify	identify	VB
cord-001835-0s7ok4uw	5219	14	functionally	functionally	RB
cord-001835-0s7ok4uw	5219	15	relevant	relevant	JJ
cord-001835-0s7ok4uw	5219	16	groups	group	NNS
cord-001835-0s7ok4uw	5219	17	through	through	IN
cord-001835-0s7ok4uw	5219	18	a	a	DT
cord-001835-0s7ok4uw	5219	19	process	process	NN
cord-001835-0s7ok4uw	5219	20	that	that	WDT
cord-001835-0s7ok4uw	5219	21	can	can	MD
cord-001835-0s7ok4uw	5219	22	be	be	VB
cord-001835-0s7ok4uw	5219	23	applied	apply	VBN
cord-001835-0s7ok4uw	5219	24	systematically	systematically	RB
cord-001835-0s7ok4uw	5219	25	and	and	CC
cord-001835-0s7ok4uw	5219	26	on	on	IN
cord-001835-0s7ok4uw	5219	27	a	a	DT
cord-001835-0s7ok4uw	5219	28	large	large	JJ
cord-001835-0s7ok4uw	5219	29	-	-	HYPH
cord-001835-0s7ok4uw	5219	30	scale	scale	NN
cord-001835-0s7ok4uw	5219	31	.	.	.
cord-001835-0s7ok4uw	5220	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	5220	2	,	,	,
cord-001835-0s7ok4uw	5220	3	the	the	DT
cord-001835-0s7ok4uw	5220	4	approach	approach	NN
cord-001835-0s7ok4uw	5220	5	can	can	MD
cord-001835-0s7ok4uw	5220	6	be	be	VB
cord-001835-0s7ok4uw	5220	7	applied	apply	VBN
cord-001835-0s7ok4uw	5220	8	more	more	RBR
cord-001835-0s7ok4uw	5220	9	quickly	quickly	RB
cord-001835-0s7ok4uw	5220	10	than	than	IN
cord-001835-0s7ok4uw	5220	11	detailed	detailed	JJ
cord-001835-0s7ok4uw	5220	12	manual	manual	JJ
cord-001835-0s7ok4uw	5220	13	curation	curation	NN
cord-001835-0s7ok4uw	5220	14	,	,	,
cord-001835-0s7ok4uw	5220	15	suggesting	suggest	VBG
cord-001835-0s7ok4uw	5220	16	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5220	17	value	value	NN
cord-001835-0s7ok4uw	5220	18	in	in	IN
cord-001835-0s7ok4uw	5220	19	guiding	guide	VBG
cord-001835-0s7ok4uw	5220	20	annotation	annotation	NN
cord-001835-0s7ok4uw	5220	21	efforts	effort	NNS
cord-001835-0s7ok4uw	5220	22	.	.	.
cord-001835-0s7ok4uw	5221	1	Dept	Dept	NNP
cord-001835-0s7ok4uw	5221	2	.	.	.
cord-001835-0s7ok4uw	5221	3	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	5221	4	and	and	CC
cord-001835-0s7ok4uw	5221	5	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	5221	6	Biology	Biology	NNP
cord-001835-0s7ok4uw	5221	7	.	.	.
cord-001835-0s7ok4uw	5222	1	University	University	NNP
cord-001835-0s7ok4uw	5222	2	of	of	IN
cord-001835-0s7ok4uw	5222	3	Valencia	Valencia	NNP
cord-001835-0s7ok4uw	5222	4	,	,	,
cord-001835-0s7ok4uw	5222	5	2	2	CD
cord-001835-0s7ok4uw	5222	6	Lab	Lab	NNP
cord-001835-0s7ok4uw	5222	7	of	of	IN
cord-001835-0s7ok4uw	5222	8	Peptide	Peptide	NNP
cord-001835-0s7ok4uw	5222	9	and	and	CC
cord-001835-0s7ok4uw	5222	10	Protein	Protein	NNP
cord-001835-0s7ok4uw	5222	11	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	5222	12	.	.	.
cord-001835-0s7ok4uw	5223	1	Centro	Centro	NNP
cord-001835-0s7ok4uw	5223	2	de	de	NNP
cord-001835-0s7ok4uw	5223	3	Investigaci	Investigaci	NNP
cord-001835-0s7ok4uw	5223	4	on	on	IN
cord-001835-0s7ok4uw	5223	5	Pr	Pr	NNP
cord-001835-0s7ok4uw	5223	6	ıncipe	ıncipe	NN
cord-001835-0s7ok4uw	5224	1	Felipe	Felipe	NNP
cord-001835-0s7ok4uw	5224	2	Membrane	membrane	NN
cord-001835-0s7ok4uw	5224	3	Proteins	protein	NNS
cord-001835-0s7ok4uw	5224	4	Changes	change	NNS
cord-001835-0s7ok4uw	5224	5	in	in	IN
cord-001835-0s7ok4uw	5224	6	the	the	DT
cord-001835-0s7ok4uw	5224	7	equilibrium	equilibrium	NN
cord-001835-0s7ok4uw	5224	8	between	between	IN
cord-001835-0s7ok4uw	5224	9	pro	pro	JJ
cord-001835-0s7ok4uw	5224	10	-	-	JJ
cord-001835-0s7ok4uw	5224	11	survival	survival	JJ
cord-001835-0s7ok4uw	5224	12	and	and	CC
cord-001835-0s7ok4uw	5224	13	pro	pro	JJ
cord-001835-0s7ok4uw	5224	14	-	-	JJ
cord-001835-0s7ok4uw	5224	15	apoptotic	apoptotic	JJ
cord-001835-0s7ok4uw	5224	16	members	member	NNS
cord-001835-0s7ok4uw	5224	17	of	of	IN
cord-001835-0s7ok4uw	5224	18	the	the	DT
cord-001835-0s7ok4uw	5224	19	B	b	NN
cord-001835-0s7ok4uw	5224	20	-	-	HYPH
cord-001835-0s7ok4uw	5224	21	cell	cell	NN
cord-001835-0s7ok4uw	5224	22	lymphoma-2	lymphoma-2	NNS
cord-001835-0s7ok4uw	5224	23	(	(	-LRB-
cord-001835-0s7ok4uw	5224	24	Bcl-2	Bcl-2	NNP
cord-001835-0s7ok4uw	5224	25	)	)	-RRB-
cord-001835-0s7ok4uw	5225	1	protein	protein	NNP
cord-001835-0s7ok4uw	5225	2	family	family	NN
cord-001835-0s7ok4uw	5225	3	at	at	IN
cord-001835-0s7ok4uw	5225	4	the	the	DT
cord-001835-0s7ok4uw	5225	5	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	5225	6	outer	outer	JJ
cord-001835-0s7ok4uw	5225	7	membrane	membrane	NN
cord-001835-0s7ok4uw	5225	8	(	(	-LRB-
cord-001835-0s7ok4uw	5225	9	MOM	mom	NN
cord-001835-0s7ok4uw	5225	10	)	)	-RRB-
cord-001835-0s7ok4uw	5225	11	induce	induce	VB
cord-001835-0s7ok4uw	5225	12	structural	structural	JJ
cord-001835-0s7ok4uw	5225	13	changes	change	NNS
cord-001835-0s7ok4uw	5225	14	that	that	WDT
cord-001835-0s7ok4uw	5225	15	committed	commit	VBD
cord-001835-0s7ok4uw	5225	16	cells	cell	NNS
cord-001835-0s7ok4uw	5225	17	to	to	IN
cord-001835-0s7ok4uw	5225	18	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	5225	19	.	.	.
cord-001835-0s7ok4uw	5226	1	Bcl-2	Bcl-2	NNP
cord-001835-0s7ok4uw	5226	2	homology-3	homology-3	NNP
cord-001835-0s7ok4uw	5226	3	(	(	-LRB-
cord-001835-0s7ok4uw	5226	4	BH3)-only	bh3)-only	NN
cord-001835-0s7ok4uw	5226	5	proteins	protein	NNS
cord-001835-0s7ok4uw	5226	6	participate	participate	VBP
cord-001835-0s7ok4uw	5226	7	in	in	IN
cord-001835-0s7ok4uw	5226	8	this	this	DT
cord-001835-0s7ok4uw	5226	9	process	process	NN
cord-001835-0s7ok4uw	5226	10	activating	activate	VBG
cord-001835-0s7ok4uw	5226	11	pro	pro	JJ
cord-001835-0s7ok4uw	5226	12	-	-	JJ
cord-001835-0s7ok4uw	5226	13	apoptotic	apoptotic	JJ
cord-001835-0s7ok4uw	5226	14	effectors	effector	NNS
cord-001835-0s7ok4uw	5226	15	and	and	CC
cord-001835-0s7ok4uw	5226	16	promoting	promote	VBG
cord-001835-0s7ok4uw	5226	17	permeabilization	permeabilization	NN
cord-001835-0s7ok4uw	5226	18	of	of	IN
cord-001835-0s7ok4uw	5226	19	the	the	DT
cord-001835-0s7ok4uw	5226	20	MOM	MOM	NNP
cord-001835-0s7ok4uw	5226	21	.	.	.
cord-001835-0s7ok4uw	5227	1	The	the	DT
cord-001835-0s7ok4uw	5227	2	membrane	membrane	NN
cord-001835-0s7ok4uw	5227	3	association	association	NN
cord-001835-0s7ok4uw	5227	4	of	of	IN
cord-001835-0s7ok4uw	5227	5	BH3-only	BH3-only	NNP
cord-001835-0s7ok4uw	5227	6	proteins	protein	NNS
cord-001835-0s7ok4uw	5227	7	is	be	VBZ
cord-001835-0s7ok4uw	5227	8	a	a	DT
cord-001835-0s7ok4uw	5227	9	controversial	controversial	JJ
cord-001835-0s7ok4uw	5227	10	issue	issue	NN
cord-001835-0s7ok4uw	5227	11	due	due	IN
cord-001835-0s7ok4uw	5227	12	to	to	IN
cord-001835-0s7ok4uw	5227	13	the	the	DT
cord-001835-0s7ok4uw	5227	14	lack	lack	NN
cord-001835-0s7ok4uw	5227	15	of	of	IN
cord-001835-0s7ok4uw	5227	16	a	a	DT
cord-001835-0s7ok4uw	5227	17	canonical	canonical	JJ
cord-001835-0s7ok4uw	5227	18	carboxyl	carboxyl	NN
cord-001835-0s7ok4uw	5227	19	-	-	HYPH
cord-001835-0s7ok4uw	5227	20	terminal	terminal	NN
cord-001835-0s7ok4uw	5227	21	(	(	-LRB-
cord-001835-0s7ok4uw	5227	22	C	c	NN
cord-001835-0s7ok4uw	5227	23	-	-	HYPH
cord-001835-0s7ok4uw	5227	24	terminal	terminal	NN
cord-001835-0s7ok4uw	5227	25	)	)	-RRB-
cord-001835-0s7ok4uw	5227	26	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	5227	27	(	(	-LRB-
cord-001835-0s7ok4uw	5227	28	TM	TM	NNP
cord-001835-0s7ok4uw	5227	29	)	)	-RRB-
cord-001835-0s7ok4uw	5227	30	domain	domain	NN
cord-001835-0s7ok4uw	5227	31	.	.	.
cord-001835-0s7ok4uw	5228	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5228	2	used	use	VBD
cord-001835-0s7ok4uw	5228	3	an	an	DT
cord-001835-0s7ok4uw	5228	4	in	in	IN
cord-001835-0s7ok4uw	5228	5	vitro	vitro	FW
cord-001835-0s7ok4uw	5228	6	transcription	transcription	NN
cord-001835-0s7ok4uw	5228	7	/	/	SYM
cord-001835-0s7ok4uw	5228	8	translation	translation	NN
cord-001835-0s7ok4uw	5228	9	system	system	NN
cord-001835-0s7ok4uw	5228	10	to	to	TO
cord-001835-0s7ok4uw	5228	11	study	study	VB
cord-001835-0s7ok4uw	5228	12	the	the	DT
cord-001835-0s7ok4uw	5228	13	insertion	insertion	NN
cord-001835-0s7ok4uw	5228	14	capacity	capacity	NN
cord-001835-0s7ok4uw	5228	15	of	of	IN
cord-001835-0s7ok4uw	5228	16	these	these	DT
cord-001835-0s7ok4uw	5228	17	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5228	18	C	c	NN
cord-001835-0s7ok4uw	5228	19	-	-	HYPH
cord-001835-0s7ok4uw	5228	20	terminal	terminal	NN
cord-001835-0s7ok4uw	5228	21	regions	region	NNS
cord-001835-0s7ok4uw	5228	22	of	of	IN
cord-001835-0s7ok4uw	5228	23	the	the	DT
cord-001835-0s7ok4uw	5228	24	BH3-members	bh3-member	NNS
cord-001835-0s7ok4uw	5228	25	Bik	Bik	NNP
cord-001835-0s7ok4uw	5228	26	,	,	,
cord-001835-0s7ok4uw	5228	27	Bim	Bim	NNP
cord-001835-0s7ok4uw	5228	28	,	,	,
cord-001835-0s7ok4uw	5228	29	Noxa	Noxa	NNP
cord-001835-0s7ok4uw	5228	30	,	,	,
cord-001835-0s7ok4uw	5228	31	Puma	Puma	NNP
cord-001835-0s7ok4uw	5228	32	and	and	CC
cord-001835-0s7ok4uw	5228	33	Bmf	Bmf	NNP
cord-001835-0s7ok4uw	5228	34	into	into	IN
cord-001835-0s7ok4uw	5228	35	microsomal	microsomal	JJ
cord-001835-0s7ok4uw	5228	36	membranes	membrane	NNS
cord-001835-0s7ok4uw	5228	37	,	,	,
cord-001835-0s7ok4uw	5228	38	and	and	CC
cord-001835-0s7ok4uw	5228	39	an	an	DT
cord-001835-0s7ok4uw	5228	40	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	5228	41	coli	coli	NNS
cord-001835-0s7ok4uw	5228	42	complementation	complementation	NN
cord-001835-0s7ok4uw	5228	43	assay	assay	NN
cord-001835-0s7ok4uw	5228	44	to	to	TO
cord-001835-0s7ok4uw	5228	45	validate	validate	VB
cord-001835-0s7ok4uw	5228	46	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5228	47	results	result	NNS
cord-001835-0s7ok4uw	5228	48	in	in	IN
cord-001835-0s7ok4uw	5228	49	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5228	50	cells	cell	NNS
cord-001835-0s7ok4uw	5228	51	.	.	.
cord-001835-0s7ok4uw	5229	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	5229	2	,	,	,
cord-001835-0s7ok4uw	5229	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	5229	4	have	have	VBP
cord-001835-0s7ok4uw	5229	5	fused	fuse	VBN
cord-001835-0s7ok4uw	5229	6	these	these	DT
cord-001835-0s7ok4uw	5229	7	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5229	8	regions	region	NNS
cord-001835-0s7ok4uw	5229	9	to	to	IN
cord-001835-0s7ok4uw	5229	10	GFP	GFP	NNP
cord-001835-0s7ok4uw	5229	11	to	to	TO
cord-001835-0s7ok4uw	5229	12	investigate	investigate	VB
cord-001835-0s7ok4uw	5229	13	the	the	DT
cord-001835-0s7ok4uw	5229	14	subcellular	subcellular	JJ
cord-001835-0s7ok4uw	5229	15	sorting	sorting	NN
cord-001835-0s7ok4uw	5229	16	.	.	.
cord-001835-0s7ok4uw	5230	1	These	these	DT
cord-001835-0s7ok4uw	5230	2	results	result	NNS
cord-001835-0s7ok4uw	5230	3	will	will	MD
cord-001835-0s7ok4uw	5230	4	allow	allow	VB
cord-001835-0s7ok4uw	5230	5	further	further	JJ
cord-001835-0s7ok4uw	5230	6	refinement	refinement	NN
cord-001835-0s7ok4uw	5230	7	in	in	IN
cord-001835-0s7ok4uw	5230	8	the	the	DT
cord-001835-0s7ok4uw	5230	9	elaboration	elaboration	NN
cord-001835-0s7ok4uw	5230	10	of	of	IN
cord-001835-0s7ok4uw	5230	11	the	the	DT
cord-001835-0s7ok4uw	5230	12	Bcl-2	Bcl-2	NNP
cord-001835-0s7ok4uw	5230	13	protein	protein	NN
cord-001835-0s7ok4uw	5230	14	-	-	HYPH
cord-001835-0s7ok4uw	5230	15	protein	protein	NN
cord-001835-0s7ok4uw	5230	16	and	and	CC
cord-001835-0s7ok4uw	5230	17	protein	protein	NN
cord-001835-0s7ok4uw	5230	18	-	-	HYPH
cord-001835-0s7ok4uw	5230	19	membrane	membrane	NN
cord-001835-0s7ok4uw	5230	20	interactome	interactome	NNP
cord-001835-0s7ok4uw	5230	21	network	network	NN
cord-001835-0s7ok4uw	5230	22	.	.	.
cord-001835-0s7ok4uw	5231	1	Alexis	Alexis	NNP
cord-001835-0s7ok4uw	5231	2	Peña	Peña	NNP
cord-001835-0s7ok4uw	5231	3	1	1	CD
cord-001835-0s7ok4uw	5231	4	,	,	,
cord-001835-0s7ok4uw	5231	5	Flaviyan	Flaviyan	NNP
cord-001835-0s7ok4uw	5231	6	Jerome	Jerome	NNP
cord-001835-0s7ok4uw	5231	7	Irudayanathan	Irudayanathan	NNP
cord-001835-0s7ok4uw	5231	8	1	1	CD
cord-001835-0s7ok4uw	5232	1	,	,	,
cord-001835-0s7ok4uw	5232	2	Shikha	Shikha	NNP
cord-001835-0s7ok4uw	5232	3	Nangia	Nangia	NNP
cord-001835-0s7ok4uw	5232	4	1	1	CD
cord-001835-0s7ok4uw	5232	5	1	1	CD
cord-001835-0s7ok4uw	5232	6	Syracuse	Syracuse	NNP
cord-001835-0s7ok4uw	5232	7	University	University	NNP
cord-001835-0s7ok4uw	5232	8	,	,	,
cord-001835-0s7ok4uw	5232	9	Dept	Dept	NNP
cord-001835-0s7ok4uw	5232	10	.	.	NNP
cord-001835-0s7ok4uw	5232	11	of	of	IN
cord-001835-0s7ok4uw	5232	12	Biomedical	Biomedical	NNP
cord-001835-0s7ok4uw	5232	13	and	and	CC
cord-001835-0s7ok4uw	5232	14	Chemical	Chemical	NNP
cord-001835-0s7ok4uw	5232	15	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	5232	16	Computational	Computational	NNP
cord-001835-0s7ok4uw	5232	17	Modeling	Modeling	NNP
cord-001835-0s7ok4uw	5232	18	,	,	,
cord-001835-0s7ok4uw	5232	19	Biostatistics	Biostatistics	NNP
cord-001835-0s7ok4uw	5232	20	,	,	,
cord-001835-0s7ok4uw	5232	21	Biomedical	Biomedical	NNP
cord-001835-0s7ok4uw	5232	22	and	and	CC
cord-001835-0s7ok4uw	5232	23	Chemical	Chemical	NNP
cord-001835-0s7ok4uw	5232	24	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	5232	25	Tight	tight	JJ
cord-001835-0s7ok4uw	5232	26	junctions	junction	NNS
cord-001835-0s7ok4uw	5232	27	(	(	-LRB-
cord-001835-0s7ok4uw	5232	28	TJ	TJ	NNP
cord-001835-0s7ok4uw	5232	29	)	)	-RRB-
cord-001835-0s7ok4uw	5232	30	are	be	VBP
cord-001835-0s7ok4uw	5232	31	vital	vital	JJ
cord-001835-0s7ok4uw	5232	32	intracellular	intracellular	JJ
cord-001835-0s7ok4uw	5232	33	barriers	barrier	NNS
cord-001835-0s7ok4uw	5232	34	that	that	WDT
cord-001835-0s7ok4uw	5232	35	are	be	VBP
cord-001835-0s7ok4uw	5232	36	responsible	responsible	JJ
cord-001835-0s7ok4uw	5232	37	for	for	IN
cord-001835-0s7ok4uw	5232	38	regulating	regulate	VBG
cord-001835-0s7ok4uw	5232	39	paracellular	paracellular	JJ
cord-001835-0s7ok4uw	5232	40	transport	transport	NN
cord-001835-0s7ok4uw	5232	41	.	.	.
cord-001835-0s7ok4uw	5233	1	Claudins	Claudins	NNP
cord-001835-0s7ok4uw	5233	2	,	,	,
cord-001835-0s7ok4uw	5233	3	a	a	DT
cord-001835-0s7ok4uw	5233	4	family	family	NN
cord-001835-0s7ok4uw	5233	5	of	of	IN
cord-001835-0s7ok4uw	5233	6	ABSTRACT	abstract	JJ
cord-001835-0s7ok4uw	5233	7	small	small	JJ
cord-001835-0s7ok4uw	5233	8	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	5233	9	proteins	protein	NNS
cord-001835-0s7ok4uw	5233	10	with	with	IN
cord-001835-0s7ok4uw	5233	11	approximately	approximately	RB
cord-001835-0s7ok4uw	5233	12	27	27	CD
cord-001835-0s7ok4uw	5233	13	members	member	NNS
cord-001835-0s7ok4uw	5233	14	,	,	,
cord-001835-0s7ok4uw	5233	15	are	be	VBP
cord-001835-0s7ok4uw	5233	16	an	an	DT
cord-001835-0s7ok4uw	5233	17	integral	integral	JJ
cord-001835-0s7ok4uw	5233	18	part	part	NN
cord-001835-0s7ok4uw	5233	19	of	of	IN
cord-001835-0s7ok4uw	5233	20	the	the	DT
cord-001835-0s7ok4uw	5233	21	TJ	TJ	NNP
cord-001835-0s7ok4uw	5233	22	strands	strand	NNS
cord-001835-0s7ok4uw	5233	23	.	.	.
cord-001835-0s7ok4uw	5234	1	Tight	tight	JJ
cord-001835-0s7ok4uw	5234	2	junctions	junction	NNS
cord-001835-0s7ok4uw	5234	3	provide	provide	VBP
cord-001835-0s7ok4uw	5234	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	5234	5	-	-	HYPH
cord-001835-0s7ok4uw	5234	6	level	level	NN
cord-001835-0s7ok4uw	5234	7	protection	protection	NN
cord-001835-0s7ok4uw	5234	8	and	and	CC
cord-001835-0s7ok4uw	5234	9	prevent	prevent	VB
cord-001835-0s7ok4uw	5234	10	infection	infection	NN
cord-001835-0s7ok4uw	5234	11	and	and	CC
cord-001835-0s7ok4uw	5234	12	toxins	toxin	NNS
cord-001835-0s7ok4uw	5234	13	from	from	IN
cord-001835-0s7ok4uw	5234	14	entering	enter	VBG
cord-001835-0s7ok4uw	5234	15	the	the	DT
cord-001835-0s7ok4uw	5234	16	body	body	NN
cord-001835-0s7ok4uw	5234	17	;	;	:
cord-001835-0s7ok4uw	5234	18	in	in	IN
cord-001835-0s7ok4uw	5234	19	the	the	DT
cord-001835-0s7ok4uw	5234	20	same	same	JJ
cord-001835-0s7ok4uw	5234	21	sense	sense	NN
cord-001835-0s7ok4uw	5234	22	TJs	tj	NNS
cord-001835-0s7ok4uw	5234	23	allow	allow	VBP
cord-001835-0s7ok4uw	5234	24	nutrients	nutrient	NNS
cord-001835-0s7ok4uw	5234	25	and	and	CC
cord-001835-0s7ok4uw	5234	26	vital	vital	JJ
cord-001835-0s7ok4uw	5234	27	solutes	solute	NNS
cord-001835-0s7ok4uw	5234	28	to	to	TO
cord-001835-0s7ok4uw	5234	29	pass	pass	VB
cord-001835-0s7ok4uw	5234	30	through	through	RP
cord-001835-0s7ok4uw	5234	31	.	.	.
cord-001835-0s7ok4uw	5235	1	Claudins	claudin	NNS
cord-001835-0s7ok4uw	5235	2	are	be	VBP
cord-001835-0s7ok4uw	5235	3	associated	associate	VBN
cord-001835-0s7ok4uw	5235	4	with	with	IN
cord-001835-0s7ok4uw	5235	5	various	various	JJ
cord-001835-0s7ok4uw	5235	6	diseases	disease	NNS
cord-001835-0s7ok4uw	5235	7	including	include	VBG
cord-001835-0s7ok4uw	5235	8	metastatic	metastatic	JJ
cord-001835-0s7ok4uw	5235	9	cancer	cancer	NN
cord-001835-0s7ok4uw	5235	10	as	as	RB
cord-001835-0s7ok4uw	5235	11	well	well	RB
cord-001835-0s7ok4uw	5235	12	as	as	IN
cord-001835-0s7ok4uw	5235	13	an	an	DT
cord-001835-0s7ok4uw	5235	14	entry	entry	NN
cord-001835-0s7ok4uw	5235	15	point	point	NN
cord-001835-0s7ok4uw	5235	16	for	for	IN
cord-001835-0s7ok4uw	5235	17	many	many	JJ
cord-001835-0s7ok4uw	5235	18	viruses	virus	NNS
cord-001835-0s7ok4uw	5235	19	.	.	.
cord-001835-0s7ok4uw	5236	1	Despite	despite	IN
cord-001835-0s7ok4uw	5236	2	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5236	3	importance	importance	NN
cord-001835-0s7ok4uw	5236	4	and	and	CC
cord-001835-0s7ok4uw	5236	5	abundance	abundance	NN
cord-001835-0s7ok4uw	5236	6	in	in	IN
cord-001835-0s7ok4uw	5236	7	all	all	DT
cord-001835-0s7ok4uw	5236	8	cell	cell	NN
cord-001835-0s7ok4uw	5236	9	membranes	membrane	NNS
cord-001835-0s7ok4uw	5236	10	and	and	CC
cord-001835-0s7ok4uw	5236	11	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5236	12	ubiquitous	ubiquitous	JJ
cord-001835-0s7ok4uw	5236	13	nature	nature	NN
cord-001835-0s7ok4uw	5236	14	,	,	,
cord-001835-0s7ok4uw	5236	15	the	the	DT
cord-001835-0s7ok4uw	5236	16	exact	exact	JJ
cord-001835-0s7ok4uw	5236	17	3-D	3-d	JJ
cord-001835-0s7ok4uw	5236	18	structure	structure	NN
cord-001835-0s7ok4uw	5236	19	of	of	IN
cord-001835-0s7ok4uw	5236	20	Claudins	Claudins	NNP
cord-001835-0s7ok4uw	5236	21	has	have	VBZ
cord-001835-0s7ok4uw	5236	22	remained	remain	VBN
cord-001835-0s7ok4uw	5236	23	elusive	elusive	JJ
cord-001835-0s7ok4uw	5236	24	to	to	IN
cord-001835-0s7ok4uw	5236	25	traditional	traditional	JJ
cord-001835-0s7ok4uw	5236	26	X	x	NN
cord-001835-0s7ok4uw	5236	27	-	-	NN
cord-001835-0s7ok4uw	5236	28	ray	ray	NN
cord-001835-0s7ok4uw	5236	29	crystallographic	crystallographic	NN
cord-001835-0s7ok4uw	5236	30	and	and	CC
cord-001835-0s7ok4uw	5236	31	NMR	NMR	NNP
cord-001835-0s7ok4uw	5236	32	studies	study	NNS
cord-001835-0s7ok4uw	5236	33	.	.	.
cord-001835-0s7ok4uw	5237	1	In	in	IN
cord-001835-0s7ok4uw	5237	2	this	this	DT
cord-001835-0s7ok4uw	5237	3	investigation	investigation	NN
cord-001835-0s7ok4uw	5237	4	,	,	,
cord-001835-0s7ok4uw	5237	5	a	a	DT
cord-001835-0s7ok4uw	5237	6	computational	computational	JJ
cord-001835-0s7ok4uw	5237	7	approach	approach	NN
cord-001835-0s7ok4uw	5237	8	was	be	VBD
cord-001835-0s7ok4uw	5237	9	used	use	VBN
cord-001835-0s7ok4uw	5237	10	to	to	TO
cord-001835-0s7ok4uw	5237	11	determine	determine	VB
cord-001835-0s7ok4uw	5237	12	the	the	DT
cord-001835-0s7ok4uw	5237	13	Claudin	Claudin	NNP
cord-001835-0s7ok4uw	5237	14	structure	structure	NN
cord-001835-0s7ok4uw	5237	15	of	of	IN
cord-001835-0s7ok4uw	5237	16	claudin	claudin	NNP
cord-001835-0s7ok4uw	5237	17	1	1	CD
cord-001835-0s7ok4uw	5237	18	-	-	SYM
cord-001835-0s7ok4uw	5237	19	10	10	CD
cord-001835-0s7ok4uw	5237	20	.	.	.
cord-001835-0s7ok4uw	5238	1	Homology	homology	NN
cord-001835-0s7ok4uw	5238	2	modeling	model	VBG
cord-001835-0s7ok4uw	5238	3	,	,	,
cord-001835-0s7ok4uw	5238	4	molecular	molecular	JJ
cord-001835-0s7ok4uw	5238	5	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	5238	6	simulations	simulation	NNS
cord-001835-0s7ok4uw	5238	7	,	,	,
cord-001835-0s7ok4uw	5238	8	and	and	CC
cord-001835-0s7ok4uw	5238	9	reverse	reverse	VB
cord-001835-0s7ok4uw	5238	10	mapping	mapping	NN
cord-001835-0s7ok4uw	5238	11	were	be	VBD
cord-001835-0s7ok4uw	5238	12	employed	employ	VBN
cord-001835-0s7ok4uw	5238	13	to	to	TO
cord-001835-0s7ok4uw	5238	14	predict	predict	VB
cord-001835-0s7ok4uw	5238	15	the	the	DT
cord-001835-0s7ok4uw	5238	16	protein	protein	NN
cord-001835-0s7ok4uw	5238	17	structures	structure	NNS
cord-001835-0s7ok4uw	5238	18	with	with	IN
cord-001835-0s7ok4uw	5238	19	relative	relative	JJ
cord-001835-0s7ok4uw	5238	20	accuracy	accuracy	NN
cord-001835-0s7ok4uw	5238	21	.	.	.
cord-001835-0s7ok4uw	5239	1	Understanding	understand	VBG
cord-001835-0s7ok4uw	5239	2	structure	structure	NN
cord-001835-0s7ok4uw	5239	3	of	of	IN
cord-001835-0s7ok4uw	5239	4	claudin	claudin	NN
cord-001835-0s7ok4uw	5239	5	proteins	protein	NNS
cord-001835-0s7ok4uw	5239	6	and	and	CC
cord-001835-0s7ok4uw	5239	7	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5239	8	interaction	interaction	NN
cord-001835-0s7ok4uw	5239	9	at	at	IN
cord-001835-0s7ok4uw	5239	10	the	the	DT
cord-001835-0s7ok4uw	5239	11	molecular	molecular	JJ
cord-001835-0s7ok4uw	5239	12	level	level	NN
cord-001835-0s7ok4uw	5239	13	can	can	MD
cord-001835-0s7ok4uw	5239	14	lead	lead	VB
cord-001835-0s7ok4uw	5239	15	to	to	IN
cord-001835-0s7ok4uw	5239	16	effective	effective	JJ
cord-001835-0s7ok4uw	5239	17	drug	drug	NN
cord-001835-0s7ok4uw	5239	18	delivery	delivery	NN
cord-001835-0s7ok4uw	5239	19	technology	technology	NN
cord-001835-0s7ok4uw	5239	20	.	.	.
cord-001835-0s7ok4uw	5240	1	Determination	determination	NN
cord-001835-0s7ok4uw	5240	2	of	of	IN
cord-001835-0s7ok4uw	5240	3	optimal	optimal	JJ
cord-001835-0s7ok4uw	5240	4	conditions	condition	NNS
cord-001835-0s7ok4uw	5240	5	for	for	IN
cord-001835-0s7ok4uw	5240	6	an	an	DT
cord-001835-0s7ok4uw	5240	7	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	5240	8	titration	titration	NN
cord-001835-0s7ok4uw	5240	9	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	5240	10	essay	essay	NN
cord-001835-0s7ok4uw	5240	11	to	to	TO
cord-001835-0s7ok4uw	5240	12	obtain	obtain	VB
cord-001835-0s7ok4uw	5240	13	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	5240	14	parameters	parameter	NNS
cord-001835-0s7ok4uw	5240	15	of	of	IN
cord-001835-0s7ok4uw	5240	16	trypsin	trypsin	NN
cord-001835-0s7ok4uw	5240	17	i	i	PRP
cord-001835-0s7ok4uw	5240	18	from	from	IN
cord-001835-0s7ok4uw	5240	19	pyloric	pyloric	JJ
cord-001835-0s7ok4uw	5240	20	caeca	caeca	NN
cord-001835-0s7ok4uw	5240	21	of	of	IN
cord-001835-0s7ok4uw	5240	22	monterey	monterey	NNP
cord-001835-0s7ok4uw	5240	23	sardine	sardine	NNP
cord-001835-0s7ok4uw	5240	24	(	(	-LRB-
cord-001835-0s7ok4uw	5240	25	Sardinops	Sardinops	NNP
cord-001835-0s7ok4uw	5240	26	sagax	sagax	NN
cord-001835-0s7ok4uw	5240	27	caerulea	caerulea	NNP
cord-001835-0s7ok4uw	5240	28	)	)	-RRB-
cord-001835-0s7ok4uw	5241	1	Idania	Idania	NNP
cord-001835-0s7ok4uw	5241	2	Emedith	Emedith	NNP
cord-001835-0s7ok4uw	5241	3	Quintero	Quintero	NNP
cord-001835-0s7ok4uw	5241	4	Reyes	Reyes	NNP
cord-001835-0s7ok4uw	5241	5	1	1	CD
cord-001835-0s7ok4uw	5241	6	,	,	,
cord-001835-0s7ok4uw	5242	1	Francisco	Francisco	NNP
cord-001835-0s7ok4uw	5242	2	Javier	Javier	NNP
cord-001835-0s7ok4uw	5242	3	Castillo	Castillo	NNP
cord-001835-0s7ok4uw	5243	1	Y	Y	NNP
cord-001835-0s7ok4uw	5243	2	añez	añez	NNP
cord-001835-0s7ok4uw	5243	3	1	1	CD
cord-001835-0s7ok4uw	5243	4	,	,	,
cord-001835-0s7ok4uw	5244	1	Enrique	Enrique	NNP
cord-001835-0s7ok4uw	5244	2	fernando	fernando	NNP
cord-001835-0s7ok4uw	5244	3	Vel	Vel	NNP
cord-001835-0s7ok4uw	5244	4	azquez	azquez	NNP
cord-001835-0s7ok4uw	5244	5	Contreras	Contreras	NNP
cord-001835-0s7ok4uw	5244	6	1	1	CD
cord-001835-0s7ok4uw	5244	7	,	,	,
cord-001835-0s7ok4uw	5244	8	Roc	Roc	NNP
cord-001835-0s7ok4uw	5244	9	ıo	ıo	IN
cord-001835-0s7ok4uw	5244	10	Sugich	Sugich	NNP
cord-001835-0s7ok4uw	5244	11	Miranda	Miranda	NNP
cord-001835-0s7ok4uw	5244	12	1	1	CD
cord-001835-0s7ok4uw	5244	13	,	,	,
cord-001835-0s7ok4uw	5244	14	David	David	NNP
cord-001835-0s7ok4uw	5244	15	Octavio	Octavio	NNP
cord-001835-0s7ok4uw	5244	16	Corona	Corona	NNP
cord-001835-0s7ok4uw	5244	17	Mart	Mart	NNP
cord-001835-0s7ok4uw	5244	18	ınez	ınez	NN
cord-001835-0s7ok4uw	5244	19	1	1	CD
cord-001835-0s7ok4uw	5244	20	,	,	,
cord-001835-0s7ok4uw	5244	21	Aldo	Aldo	NNP
cord-001835-0s7ok4uw	5244	22	Alejandro	Alejandro	NNP
cord-001835-0s7ok4uw	5244	23	Arvizu	Arvizu	NNP
cord-001835-0s7ok4uw	5244	24	Flores	Flores	NNP
cord-001835-0s7ok4uw	5244	25	1	1	CD
cord-001835-0s7ok4uw	5244	26	,	,	,
cord-001835-0s7ok4uw	5244	27	Ivet	Ivet	NNP
cord-001835-0s7ok4uw	5244	28	Cervantes	Cervantes	NNP
cord-001835-0s7ok4uw	5244	29	Dom	Dom	NNP
cord-001835-0s7ok4uw	5244	30	ınguez	ınguez	NNP
cord-001835-0s7ok4uw	5244	31	1	1	CD
cord-001835-0s7ok4uw	5244	32	1	1	CD
cord-001835-0s7ok4uw	5244	33	Protein	Protein	NNP
cord-001835-0s7ok4uw	5244	34	Kinetics	Kinetics	NNP
cord-001835-0s7ok4uw	5244	35	Determination	determination	NN
cord-001835-0s7ok4uw	5244	36	of	of	IN
cord-001835-0s7ok4uw	5244	37	Optimal	Optimal	NNP
cord-001835-0s7ok4uw	5244	38	Conditions	condition	NNS
cord-001835-0s7ok4uw	5244	39	for	for	IN
cord-001835-0s7ok4uw	5244	40	an	an	DT
cord-001835-0s7ok4uw	5244	41	Isothermal	Isothermal	NNP
cord-001835-0s7ok4uw	5244	42	Titration	Titration	NNP
cord-001835-0s7ok4uw	5244	43	Calorimetry	Calorimetry	NNP
cord-001835-0s7ok4uw	5244	44	Essay	Essay	NNP
cord-001835-0s7ok4uw	5245	1	to	to	TO
cord-001835-0s7ok4uw	5245	2	Obtain	obtain	VB
cord-001835-0s7ok4uw	5245	3	Kinetic	kinetic	JJ
cord-001835-0s7ok4uw	5245	4	Parameters	parameter	NNS
cord-001835-0s7ok4uw	5245	5	of	of	IN
cord-001835-0s7ok4uw	5245	6	Trypsin	Trypsin	NNP
cord-001835-0s7ok4uw	5245	7	I	-PRON-	PRP
cord-001835-0s7ok4uw	5245	8	from	from	IN
cord-001835-0s7ok4uw	5245	9	Pyloric	Pyloric	NNP
cord-001835-0s7ok4uw	5245	10	Caeca	Caeca	NNP
cord-001835-0s7ok4uw	5245	11	of	of	IN
cord-001835-0s7ok4uw	5245	12	Monterey	Monterey	NNP
cord-001835-0s7ok4uw	5245	13	Sardine	Sardine	NNP
cord-001835-0s7ok4uw	5245	14	(	(	-LRB-
cord-001835-0s7ok4uw	5245	15	Sardinops	Sardinops	NNP
cord-001835-0s7ok4uw	5245	16	sagax	sagax	NN
cord-001835-0s7ok4uw	5245	17	caerulea	caerulea	NNP
cord-001835-0s7ok4uw	5245	18	)	)	-RRB-
cord-001835-0s7ok4uw	5246	1	Trypsin	Trypsin	NNP
cord-001835-0s7ok4uw	5246	2	is	be	VBZ
cord-001835-0s7ok4uw	5246	3	the	the	DT
cord-001835-0s7ok4uw	5246	4	most	most	RBS
cord-001835-0s7ok4uw	5246	5	studied	study	VBN
cord-001835-0s7ok4uw	5246	6	alkaline	alkaline	JJ
cord-001835-0s7ok4uw	5246	7	protease	protease	NN
cord-001835-0s7ok4uw	5246	8	and	and	CC
cord-001835-0s7ok4uw	5246	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	5246	10	s	s	VBZ
cord-001835-0s7ok4uw	5246	11	very	very	RB
cord-001835-0s7ok4uw	5246	12	common	common	JJ
cord-001835-0s7ok4uw	5246	13	to	to	TO
cord-001835-0s7ok4uw	5246	14	found	find	VBN
cord-001835-0s7ok4uw	5246	15	isoforms	isoform	NNS
cord-001835-0s7ok4uw	5246	16	from	from	IN
cord-001835-0s7ok4uw	5246	17	this	this	DT
cord-001835-0s7ok4uw	5246	18	protein	protein	NN
cord-001835-0s7ok4uw	5246	19	as	as	IN
cord-001835-0s7ok4uw	5246	20	the	the	DT
cord-001835-0s7ok4uw	5246	21	case	case	NN
cord-001835-0s7ok4uw	5246	22	for	for	IN
cord-001835-0s7ok4uw	5246	23	Monterey	Monterey	NNP
cord-001835-0s7ok4uw	5246	24	sardine	sardine	NN
cord-001835-0s7ok4uw	5246	25	(	(	-LRB-
cord-001835-0s7ok4uw	5246	26	Sardinops	Sardinops	NNP
cord-001835-0s7ok4uw	5246	27	sagax	sagax	NN
cord-001835-0s7ok4uw	5246	28	caerulea	caerulea	NNP
cord-001835-0s7ok4uw	5246	29	)	)	-RRB-
cord-001835-0s7ok4uw	5246	30	;	;	:
cord-001835-0s7ok4uw	5246	31	as	as	IN
cord-001835-0s7ok4uw	5246	32	it	-PRON-	PRP
cord-001835-0s7ok4uw	5246	33	shows	show	VBZ
cord-001835-0s7ok4uw	5246	34	an	an	DT
cord-001835-0s7ok4uw	5246	35	expression	expression	NN
cord-001835-0s7ok4uw	5246	36	of	of	IN
cord-001835-0s7ok4uw	5246	37	trypsin	trypsin	NN
cord-001835-0s7ok4uw	5246	38	I	-PRON-	PRP
cord-001835-0s7ok4uw	5246	39	and	and	CC
cord-001835-0s7ok4uw	5246	40	trypsin	trypsin	NN
cord-001835-0s7ok4uw	5246	41	III	III	NNP
cord-001835-0s7ok4uw	5246	42	according	accord	VBG
cord-001835-0s7ok4uw	5246	43	to	to	IN
cord-001835-0s7ok4uw	5246	44	the	the	DT
cord-001835-0s7ok4uw	5246	45	cDNA	cdna	NN
cord-001835-0s7ok4uw	5246	46	characterization	characterization	NN
cord-001835-0s7ok4uw	5246	47	.	.	.
cord-001835-0s7ok4uw	5247	1	Trypsin	Trypsin	NNP
cord-001835-0s7ok4uw	5247	2	I	-PRON-	PRP
cord-001835-0s7ok4uw	5247	3	was	be	VBD
cord-001835-0s7ok4uw	5247	4	determine	determine	NN
cord-001835-0s7ok4uw	5247	5	to	to	TO
cord-001835-0s7ok4uw	5247	6	be	be	VB
cord-001835-0s7ok4uw	5247	7	a	a	DT
cord-001835-0s7ok4uw	5247	8	cold	cold	JJ
cord-001835-0s7ok4uw	5247	9	adapted	adapt	VBN
cord-001835-0s7ok4uw	5247	10	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5247	11	as	as	IN
cord-001835-0s7ok4uw	5247	12	it	-PRON-	PRP
cord-001835-0s7ok4uw	5247	13	shows	show	VBZ
cord-001835-0s7ok4uw	5247	14	a	a	DT
cord-001835-0s7ok4uw	5247	15	higher	high	JJR
cord-001835-0s7ok4uw	5247	16	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5247	17	efficiency	efficiency	NN
cord-001835-0s7ok4uw	5247	18	(	(	-LRB-
cord-001835-0s7ok4uw	5247	19	kcat	kcat	NNP
cord-001835-0s7ok4uw	5247	20	/	/	SYM
cord-001835-0s7ok4uw	5247	21	KM	KM	NNP
cord-001835-0s7ok4uw	5247	22	)	)	-RRB-
cord-001835-0s7ok4uw	5247	23	than	than	IN
cord-001835-0s7ok4uw	5247	24	the	the	DT
cord-001835-0s7ok4uw	5247	25	mesophilic	mesophilic	NNP
cord-001835-0s7ok4uw	5247	26	counterparts	counterpart	NNS
cord-001835-0s7ok4uw	5247	27	.	.	.
cord-001835-0s7ok4uw	5248	1	The	the	DT
cord-001835-0s7ok4uw	5248	2	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	5248	3	parameters	parameter	NNS
cord-001835-0s7ok4uw	5248	4	were	be	VBD
cord-001835-0s7ok4uw	5248	5	obtained	obtain	VBN
cord-001835-0s7ok4uw	5248	6	by	by	IN
cord-001835-0s7ok4uw	5248	7	spectrophotometric	spectrophotometric	JJ
cord-001835-0s7ok4uw	5248	8	essays	essay	NNS
cord-001835-0s7ok4uw	5248	9	,	,	,
cord-001835-0s7ok4uw	5248	10	which	which	WDT
cord-001835-0s7ok4uw	5248	11	are	be	VBP
cord-001835-0s7ok4uw	5248	12	not	not	RB
cord-001835-0s7ok4uw	5248	13	fallible	fallible	JJ
cord-001835-0s7ok4uw	5248	14	for	for	IN
cord-001835-0s7ok4uw	5248	15	all	all	PDT
cord-001835-0s7ok4uw	5248	16	the	the	DT
cord-001835-0s7ok4uw	5248	17	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5248	18	because	because	IN
cord-001835-0s7ok4uw	5248	19	native	native	JJ
cord-001835-0s7ok4uw	5248	20	,	,	,
cord-001835-0s7ok4uw	5248	21	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	5248	22	or	or	CC
cord-001835-0s7ok4uw	5248	23	mutant	mutant	JJ
cord-001835-0s7ok4uw	5248	24	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5248	25	activity	activity	NN
cord-001835-0s7ok4uw	5248	26	could	could	MD
cord-001835-0s7ok4uw	5248	27	be	be	VB
cord-001835-0s7ok4uw	5248	28	below	below	IN
cord-001835-0s7ok4uw	5248	29	the	the	DT
cord-001835-0s7ok4uw	5248	30	detection	detection	NN
cord-001835-0s7ok4uw	5248	31	limit	limit	NN
cord-001835-0s7ok4uw	5248	32	of	of	IN
cord-001835-0s7ok4uw	5248	33	the	the	DT
cord-001835-0s7ok4uw	5248	34	assay	assay	NN
cord-001835-0s7ok4uw	5248	35	,	,	,
cord-001835-0s7ok4uw	5248	36	opaque	opaque	JJ
cord-001835-0s7ok4uw	5248	37	or	or	CC
cord-001835-0s7ok4uw	5248	38	turbid	turbid	JJ
cord-001835-0s7ok4uw	5248	39	solutions	solution	NNS
cord-001835-0s7ok4uw	5248	40	interfere	interfere	VBP
cord-001835-0s7ok4uw	5248	41	with	with	IN
cord-001835-0s7ok4uw	5248	42	spectrophotometric	spectrophotometric	JJ
cord-001835-0s7ok4uw	5248	43	detection	detection	NN
cord-001835-0s7ok4uw	5248	44	,	,	,
cord-001835-0s7ok4uw	5248	45	etc	etc	FW
cord-001835-0s7ok4uw	5248	46	.	.	.
cord-001835-0s7ok4uw	5249	1	Alternative	alternative	JJ
cord-001835-0s7ok4uw	5249	2	tools	tool	NNS
cord-001835-0s7ok4uw	5249	3	as	as	IN
cord-001835-0s7ok4uw	5249	4	the	the	DT
cord-001835-0s7ok4uw	5249	5	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	5249	6	titration	titration	NN
cord-001835-0s7ok4uw	5249	7	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	5249	8	(	(	-LRB-
cord-001835-0s7ok4uw	5249	9	ITC	ITC	NNP
cord-001835-0s7ok4uw	5249	10	)	)	-RRB-
cord-001835-0s7ok4uw	5249	11	can	can	MD
cord-001835-0s7ok4uw	5249	12	measure	measure	VB
cord-001835-0s7ok4uw	5249	13	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5249	14	kinetics	kinetics	NN
cord-001835-0s7ok4uw	5249	15	using	use	VBG
cord-001835-0s7ok4uw	5249	16	thermal	thermal	JJ
cord-001835-0s7ok4uw	5249	17	power	power	NN
cord-001835-0s7ok4uw	5249	18	generated	generate	VBN
cord-001835-0s7ok4uw	5249	19	by	by	IN
cord-001835-0s7ok4uw	5249	20	the	the	DT
cord-001835-0s7ok4uw	5249	21	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5249	22	conversion	conversion	NN
cord-001835-0s7ok4uw	5249	23	of	of	IN
cord-001835-0s7ok4uw	5249	24	substrate	substrate	NN
cord-001835-0s7ok4uw	5249	25	to	to	IN
cord-001835-0s7ok4uw	5249	26	product	product	NN
cord-001835-0s7ok4uw	5249	27	;	;	:
cord-001835-0s7ok4uw	5249	28	were	be	VBD
cord-001835-0s7ok4uw	5249	29	the	the	DT
cord-001835-0s7ok4uw	5249	30	rate	rate	NN
cord-001835-0s7ok4uw	5249	31	of	of	IN
cord-001835-0s7ok4uw	5249	32	reaction	reaction	NN
cord-001835-0s7ok4uw	5249	33	is	be	VBZ
cord-001835-0s7ok4uw	5249	34	directly	directly	RB
cord-001835-0s7ok4uw	5249	35	proportional	proportional	JJ
cord-001835-0s7ok4uw	5249	36	to	to	IN
cord-001835-0s7ok4uw	5249	37	thermal	thermal	JJ
cord-001835-0s7ok4uw	5249	38	power	power	NN
cord-001835-0s7ok4uw	5249	39	.	.	.
cord-001835-0s7ok4uw	5250	1	The	the	DT
cord-001835-0s7ok4uw	5250	2	objective	objective	NN
cord-001835-0s7ok4uw	5250	3	of	of	IN
cord-001835-0s7ok4uw	5250	4	this	this	DT
cord-001835-0s7ok4uw	5250	5	study	study	NN
cord-001835-0s7ok4uw	5250	6	was	be	VBD
cord-001835-0s7ok4uw	5250	7	to	to	TO
cord-001835-0s7ok4uw	5250	8	stablish	stablish	VB
cord-001835-0s7ok4uw	5250	9	the	the	DT
cord-001835-0s7ok4uw	5250	10	optimum	optimum	JJ
cord-001835-0s7ok4uw	5250	11	conditions	condition	NNS
cord-001835-0s7ok4uw	5250	12	to	to	TO
cord-001835-0s7ok4uw	5250	13	obtain	obtain	VB
cord-001835-0s7ok4uw	5250	14	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	5250	15	parameters	parameter	NNS
cord-001835-0s7ok4uw	5250	16	of	of	IN
cord-001835-0s7ok4uw	5250	17	Trypsin	Trypsin	NNP
cord-001835-0s7ok4uw	5250	18	I	-PRON-	PRP
cord-001835-0s7ok4uw	5250	19	from	from	IN
cord-001835-0s7ok4uw	5250	20	pyloric	pyloric	JJ
cord-001835-0s7ok4uw	5250	21	caeca	caeca	NN
cord-001835-0s7ok4uw	5250	22	of	of	IN
cord-001835-0s7ok4uw	5250	23	Monterey	Monterey	NNP
cord-001835-0s7ok4uw	5250	24	sardine	sardine	NN
cord-001835-0s7ok4uw	5250	25	using	use	VBG
cord-001835-0s7ok4uw	5250	26	ITC	ITC	NNP
cord-001835-0s7ok4uw	5250	27	.	.	.
cord-001835-0s7ok4uw	5251	1	To	to	TO
cord-001835-0s7ok4uw	5251	2	reach	reach	VB
cord-001835-0s7ok4uw	5251	3	the	the	DT
cord-001835-0s7ok4uw	5251	4	objective	objective	JJ
cord-001835-0s7ok4uw	5251	5	Trypsin	Trypsin	NNP
cord-001835-0s7ok4uw	5251	6	I	-PRON-	PRP
cord-001835-0s7ok4uw	5251	7	was	be	VBD
cord-001835-0s7ok4uw	5251	8	purified	purify	VBN
cord-001835-0s7ok4uw	5251	9	from	from	IN
cord-001835-0s7ok4uw	5251	10	viscera	viscera	NNS
cord-001835-0s7ok4uw	5251	11	of	of	IN
cord-001835-0s7ok4uw	5251	12	Monterey	Monterey	NNP
cord-001835-0s7ok4uw	5251	13	sardine	sardine	NN
cord-001835-0s7ok4uw	5251	14	using	use	VBG
cord-001835-0s7ok4uw	5251	15	molecular	molecular	JJ
cord-001835-0s7ok4uw	5251	16	exclusion	exclusion	NN
cord-001835-0s7ok4uw	5251	17	and	and	CC
cord-001835-0s7ok4uw	5251	18	affinity	affinity	NN
cord-001835-0s7ok4uw	5251	19	chromatography	chromatography	NN
cord-001835-0s7ok4uw	5251	20	obtaining	obtain	VBG
cord-001835-0s7ok4uw	5251	21	a	a	DT
cord-001835-0s7ok4uw	5251	22	yield	yield	NN
cord-001835-0s7ok4uw	5251	23	of	of	IN
cord-001835-0s7ok4uw	5251	24	1.1	1.1	CD
cord-001835-0s7ok4uw	5251	25	mg	mg	NNP
cord-001835-0s7ok4uw	5251	26	/	/	SYM
cord-001835-0s7ok4uw	5251	27	mL.	mL.	NNS
cord-001835-0s7ok4uw	5251	28	At	at	IN
cord-001835-0s7ok4uw	5251	29	208C	208c	CD
cord-001835-0s7ok4uw	5251	30	kcat	kcat	NNP
cord-001835-0s7ok4uw	5251	31	and	and	CC
cord-001835-0s7ok4uw	5251	32	KM	KM	NNP
cord-001835-0s7ok4uw	5251	33	of	of	IN
cord-001835-0s7ok4uw	5251	34	Tryipsin	Tryipsin	NNP
cord-001835-0s7ok4uw	5252	1	I	-PRON-	PRP
cord-001835-0s7ok4uw	5252	2	form	form	VBP
cord-001835-0s7ok4uw	5252	3	Monterey	Monterey	NNP
cord-001835-0s7ok4uw	5252	4	sardine	sardine	NN
cord-001835-0s7ok4uw	5252	5	were	be	VBD
cord-001835-0s7ok4uw	5252	6	14.6	14.6	CD
cord-001835-0s7ok4uw	5252	7	s-1	s-1	NNS
cord-001835-0s7ok4uw	5252	8	and	and	CC
cord-001835-0s7ok4uw	5252	9	1.4	1.4	CD
cord-001835-0s7ok4uw	5252	10	mM	mm	CD
cord-001835-0s7ok4uw	5252	11	respectively	respectively	RB
cord-001835-0s7ok4uw	5252	12	.	.	.
cord-001835-0s7ok4uw	5253	1	At	at	IN
cord-001835-0s7ok4uw	5253	2	158C	158c	CD
cord-001835-0s7ok4uw	5253	3	were	be	VBD
cord-001835-0s7ok4uw	5253	4	13.6	13.6	CD
cord-001835-0s7ok4uw	5253	5	s-1	s-1	NN
cord-001835-0s7ok4uw	5253	6	and	and	CC
cord-001835-0s7ok4uw	5253	7	4	4	CD
cord-001835-0s7ok4uw	5253	8	mM	mm	CD
cord-001835-0s7ok4uw	5253	9	(	(	-LRB-
cord-001835-0s7ok4uw	5253	10	kcat	kcat	NNP
cord-001835-0s7ok4uw	5253	11	and	and	CC
cord-001835-0s7ok4uw	5253	12	KM	KM	NNP
cord-001835-0s7ok4uw	5253	13	)	)	-RRB-
cord-001835-0s7ok4uw	5253	14	and	and	CC
cord-001835-0s7ok4uw	5253	15	at	at	IN
cord-001835-0s7ok4uw	5253	16	48C	48c	CD
cord-001835-0s7ok4uw	5253	17	kcat	kcat	NNP
cord-001835-0s7ok4uw	5253	18	was	be	VBD
cord-001835-0s7ok4uw	5253	19	0.454	0.454	CD
cord-001835-0s7ok4uw	5253	20	s-1	s-1	NN
cord-001835-0s7ok4uw	5253	21	and	and	CC
cord-001835-0s7ok4uw	5253	22	KM	KM	NNP
cord-001835-0s7ok4uw	5253	23	0.52	0.52	CD
cord-001835-0s7ok4uw	5253	24	mM.	mm.	NN
cord-001835-0s7ok4uw	5254	1	The	the	DT
cord-001835-0s7ok4uw	5254	2	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	5254	3	parameters	parameter	NNS
cord-001835-0s7ok4uw	5254	4	obtained	obtain	VBN
cord-001835-0s7ok4uw	5254	5	by	by	IN
cord-001835-0s7ok4uw	5254	6	spectrophotometric	spectrophotometric	JJ
cord-001835-0s7ok4uw	5254	7	assay	assay	NN
cord-001835-0s7ok4uw	5254	8	at	at	IN
cord-001835-0s7ok4uw	5254	9	258C	258c	CD
cord-001835-0s7ok4uw	5254	10	were	be	VBD
cord-001835-0s7ok4uw	5254	11	kcat	kcat	NNP
cord-001835-0s7ok4uw	5254	12	and	and	CC
cord-001835-0s7ok4uw	5254	13	KM	KM	NNP
cord-001835-0s7ok4uw	5254	14	436	436	CD
cord-001835-0s7ok4uw	5254	15	s-1	s-1	NNS
cord-001835-0s7ok4uw	5254	16	and	and	CC
cord-001835-0s7ok4uw	5254	17	1.8	1.8	CD
cord-001835-0s7ok4uw	5254	18	mM	mm	CD
cord-001835-0s7ok4uw	5254	19	respectively	respectively	RB
cord-001835-0s7ok4uw	5254	20	.	.	.
cord-001835-0s7ok4uw	5255	1	At	at	IN
cord-001835-0s7ok4uw	5255	2	208C	208c	CD
cord-001835-0s7ok4uw	5255	3	the	the	DT
cord-001835-0s7ok4uw	5255	4	kcat	kcat	NNP
cord-001835-0s7ok4uw	5255	5	was	be	VBD
cord-001835-0s7ok4uw	5255	6	409.7	409.7	CD
cord-001835-0s7ok4uw	5255	7	s-1	s-1	NN
cord-001835-0s7ok4uw	5255	8	and	and	CC
cord-001835-0s7ok4uw	5255	9	KM	KM	NNP
cord-001835-0s7ok4uw	5255	10	1.8	1.8	CD
cord-001835-0s7ok4uw	5255	11	mM	mm	CD
cord-001835-0s7ok4uw	5255	12	and	and	CC
cord-001835-0s7ok4uw	5255	13	at	at	IN
cord-001835-0s7ok4uw	5255	14	158C	158c	CD
cord-001835-0s7ok4uw	5255	15	kcat	kcat	NNP
cord-001835-0s7ok4uw	5255	16	288	288	CD
cord-001835-0s7ok4uw	5255	17	s-1	s-1	NN
cord-001835-0s7ok4uw	5255	18	and	and	CC
cord-001835-0s7ok4uw	5255	19	KM	KM	NNP
cord-001835-0s7ok4uw	5255	20	3mM.	3mm.	CD
cord-001835-0s7ok4uw	5256	1	Comparing	compare	VBG
cord-001835-0s7ok4uw	5256	2	the	the	DT
cord-001835-0s7ok4uw	5256	3	values	value	NNS
cord-001835-0s7ok4uw	5256	4	obtained	obtain	VBN
cord-001835-0s7ok4uw	5256	5	for	for	IN
cord-001835-0s7ok4uw	5256	6	kcat	kcat	NNP
cord-001835-0s7ok4uw	5256	7	with	with	IN
cord-001835-0s7ok4uw	5256	8	the	the	DT
cord-001835-0s7ok4uw	5256	9	spectrophotometric	spectrophotometric	JJ
cord-001835-0s7ok4uw	5256	10	essay	essay	NN
cord-001835-0s7ok4uw	5256	11	were	be	VBD
cord-001835-0s7ok4uw	5256	12	higher	high	JJR
cord-001835-0s7ok4uw	5256	13	29	29	CD
cord-001835-0s7ok4uw	5256	14	fold	fold	NN
cord-001835-0s7ok4uw	5256	15	than	than	IN
cord-001835-0s7ok4uw	5256	16	those	those	DT
cord-001835-0s7ok4uw	5256	17	obtained	obtain	VBN
cord-001835-0s7ok4uw	5256	18	by	by	IN
cord-001835-0s7ok4uw	5256	19	ITC	ITC	NNP
cord-001835-0s7ok4uw	5256	20	and	and	CC
cord-001835-0s7ok4uw	5256	21	the	the	DT
cord-001835-0s7ok4uw	5256	22	values	value	NNS
cord-001835-0s7ok4uw	5256	23	in	in	IN
cord-001835-0s7ok4uw	5256	24	KM	KM	NNP
cord-001835-0s7ok4uw	5256	25	were	be	VBD
cord-001835-0s7ok4uw	5256	26	similar	similar	JJ
cord-001835-0s7ok4uw	5256	27	by	by	IN
cord-001835-0s7ok4uw	5256	28	both	both	DT
cord-001835-0s7ok4uw	5256	29	methods	method	NNS
cord-001835-0s7ok4uw	5256	30	.	.	.
cord-001835-0s7ok4uw	5257	1	Even	even	RB
cord-001835-0s7ok4uw	5257	2	though	though	IN
cord-001835-0s7ok4uw	5257	3	the	the	DT
cord-001835-0s7ok4uw	5257	4	differences	difference	NNS
cord-001835-0s7ok4uw	5257	5	in	in	IN
cord-001835-0s7ok4uw	5257	6	kcat	kcat	NNP
cord-001835-0s7ok4uw	5257	7	,	,	,
cord-001835-0s7ok4uw	5257	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	5257	9	can	can	MD
cord-001835-0s7ok4uw	5257	10	reassert	reassert	VB
cord-001835-0s7ok4uw	5257	11	the	the	DT
cord-001835-0s7ok4uw	5257	12	psychrophilic	psychrophilic	NN
cord-001835-0s7ok4uw	5257	13	behavior	behavior	NN
cord-001835-0s7ok4uw	5257	14	of	of	IN
cord-001835-0s7ok4uw	5257	15	trypsin	trypsin	NN
cord-001835-0s7ok4uw	5257	16	I	-PRON-	PRP
cord-001835-0s7ok4uw	5257	17	as	as	IN
cord-001835-0s7ok4uw	5257	18	the	the	DT
cord-001835-0s7ok4uw	5257	19	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5257	20	efficiency	efficiency	NN
cord-001835-0s7ok4uw	5257	21	is	be	VBZ
cord-001835-0s7ok4uw	5257	22	higher	high	JJR
cord-001835-0s7ok4uw	5257	23	by	by	IN
cord-001835-0s7ok4uw	5257	24	both	both	DT
cord-001835-0s7ok4uw	5257	25	methodologies	methodology	NNS
cord-001835-0s7ok4uw	5257	26	.	.	.
cord-001835-0s7ok4uw	5258	1	In	in	IN
cord-001835-0s7ok4uw	5258	2	the	the	DT
cord-001835-0s7ok4uw	5258	3	understanding	understanding	NN
cord-001835-0s7ok4uw	5258	4	that	that	WDT
cord-001835-0s7ok4uw	5258	5	the	the	DT
cord-001835-0s7ok4uw	5258	6	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	5258	7	behavior	behavior	NN
cord-001835-0s7ok4uw	5258	8	of	of	IN
cord-001835-0s7ok4uw	5258	9	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5258	10	is	be	VBZ
cord-001835-0s7ok4uw	5258	11	important	important	JJ
cord-001835-0s7ok4uw	5258	12	to	to	IN
cord-001835-0s7ok4uw	5258	13	not	not	RB
cord-001835-0s7ok4uw	5258	14	only	only	RB
cord-001835-0s7ok4uw	5258	15	understanding	understand	VBG
cord-001835-0s7ok4uw	5258	16	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5258	17	pathways	pathway	NNS
cord-001835-0s7ok4uw	5258	18	and	and	CC
cord-001835-0s7ok4uw	5258	19	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5258	20	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	5258	21	but	but	CC
cord-001835-0s7ok4uw	5258	22	is	be	VBZ
cord-001835-0s7ok4uw	5258	23	again	again	RB
cord-001835-0s7ok4uw	5258	24	a	a	DT
cord-001835-0s7ok4uw	5258	25	fruitful	fruitful	JJ
cord-001835-0s7ok4uw	5258	26	area	area	NN
cord-001835-0s7ok4uw	5258	27	for	for	IN
cord-001835-0s7ok4uw	5258	28	drug	drug	NN
cord-001835-0s7ok4uw	5258	29	discovery	discovery	NN
cord-001835-0s7ok4uw	5258	30	and	and	CC
cord-001835-0s7ok4uw	5258	31	development	development	NN
cord-001835-0s7ok4uw	5258	32	;	;	:
cord-001835-0s7ok4uw	5258	33	so	so	RB
cord-001835-0s7ok4uw	5258	34	the	the	DT
cord-001835-0s7ok4uw	5258	35	ITC	ITC	NNP
cord-001835-0s7ok4uw	5258	36	provides	provide	VBZ
cord-001835-0s7ok4uw	5258	37	a	a	DT
cord-001835-0s7ok4uw	5258	38	universal	universal	JJ
cord-001835-0s7ok4uw	5258	39	approach	approach	NN
cord-001835-0s7ok4uw	5258	40	to	to	IN
cord-001835-0s7ok4uw	5258	41	determining	determine	VBG
cord-001835-0s7ok4uw	5258	42	the	the	DT
cord-001835-0s7ok4uw	5258	43	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	5258	44	behavior	behavior	NN
cord-001835-0s7ok4uw	5258	45	of	of	IN
cord-001835-0s7ok4uw	5258	46	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5258	47	and	and	CC
cord-001835-0s7ok4uw	5258	48	can	can	MD
cord-001835-0s7ok4uw	5258	49	yield	yield	VB
cord-001835-0s7ok4uw	5258	50	in	in	IN
cord-001835-0s7ok4uw	5258	51	a	a	DT
cord-001835-0s7ok4uw	5258	52	single	single	JJ
cord-001835-0s7ok4uw	5258	53	experiment	experiment	NN
cord-001835-0s7ok4uw	5258	54	a	a	DT
cord-001835-0s7ok4uw	5258	55	complete	complete	JJ
cord-001835-0s7ok4uw	5258	56	set	set	NN
cord-001835-0s7ok4uw	5258	57	of	of	IN
cord-001835-0s7ok4uw	5258	58	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	5258	59	parameters	parameter	NNS
cord-001835-0s7ok4uw	5258	60	for	for	IN
cord-001835-0s7ok4uw	5258	61	an	an	DT
cord-001835-0s7ok4uw	5258	62	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5258	63	-	-	HYPH
cord-001835-0s7ok4uw	5258	64	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	5258	65	reaction	reaction	NN
cord-001835-0s7ok4uw	5258	66	that	that	WDT
cord-001835-0s7ok4uw	5258	67	can	can	MD
cord-001835-0s7ok4uw	5258	68	be	be	VB
cord-001835-0s7ok4uw	5258	69	applied	apply	VBN
cord-001835-0s7ok4uw	5258	70	for	for	IN
cord-001835-0s7ok4uw	5258	71	the	the	DT
cord-001835-0s7ok4uw	5258	72	different	different	JJ
cord-001835-0s7ok4uw	5258	73	alkaline	alkaline	JJ
cord-001835-0s7ok4uw	5258	74	proteases	protease	NNS
cord-001835-0s7ok4uw	5258	75	from	from	IN
cord-001835-0s7ok4uw	5258	76	pyloric	pyloric	JJ
cord-001835-0s7ok4uw	5258	77	caeca	caeca	NN
cord-001835-0s7ok4uw	5258	78	of	of	IN
cord-001835-0s7ok4uw	5258	79	Monterey	Monterey	NNP
cord-001835-0s7ok4uw	5258	80	sardine	sardine	NN
cord-001835-0s7ok4uw	5258	81	(	(	-LRB-
cord-001835-0s7ok4uw	5258	82	Sardinops	Sardinops	NNP
cord-001835-0s7ok4uw	5258	83	sagax	sagax	NN
cord-001835-0s7ok4uw	5258	84	caerulea	caerulea	NNP
cord-001835-0s7ok4uw	5258	85	)	)	-RRB-
cord-001835-0s7ok4uw	5258	86	.	.	.
cord-001835-0s7ok4uw	5259	1	Mysterious	mysterious	JJ
cord-001835-0s7ok4uw	5259	2	world	world	NN
cord-001835-0s7ok4uw	5259	3	of	of	IN
cord-001835-0s7ok4uw	5259	4	stress	stress	NN
cord-001835-0s7ok4uw	5259	5	-	-	HYPH
cord-001835-0s7ok4uw	5259	6	responding	respond	VBG
cord-001835-0s7ok4uw	5259	7	sigma	sigma	NN
cord-001835-0s7ok4uw	5259	8	factors	factor	NNS
cord-001835-0s7ok4uw	5259	9	in	in	IN
cord-001835-0s7ok4uw	5259	10	Bacillus	bacillus	NN
cord-001835-0s7ok4uw	5259	11	subtilis	subtili	VBZ
cord-001835-0s7ok4uw	5259	12	Olga	Olga	NNP
cord-001835-0s7ok4uw	5259	13	Ramaniuk	Ramaniuk	NNP
cord-001835-0s7ok4uw	5260	1	1	1	CD
cord-001835-0s7ok4uw	5260	2	1	1	CD
cord-001835-0s7ok4uw	5260	3	Protein	Protein	NNP
cord-001835-0s7ok4uw	5260	4	-	-	HYPH
cord-001835-0s7ok4uw	5260	5	DNA	dna	NN
cord-001835-0s7ok4uw	5260	6	interaction	interaction	NN
cord-001835-0s7ok4uw	5260	7	Bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5260	8	transcription	transcription	NN
cord-001835-0s7ok4uw	5260	9	is	be	VBZ
cord-001835-0s7ok4uw	5260	10	mediated	mediate	VBN
cord-001835-0s7ok4uw	5260	11	by	by	IN
cord-001835-0s7ok4uw	5260	12	the	the	DT
cord-001835-0s7ok4uw	5260	13	RNA	RNA	NNP
cord-001835-0s7ok4uw	5260	14	polymerase	polymerase	NN
cord-001835-0s7ok4uw	5260	15	holoenzyme	holoenzyme	NNP
cord-001835-0s7ok4uw	5260	16	containing	contain	VBG
cord-001835-0s7ok4uw	5260	17	sigma	sigma	NNP
cord-001835-0s7ok4uw	5260	18	factors	factor	NNS
cord-001835-0s7ok4uw	5260	19	-essential	-essential	SYM
cord-001835-0s7ok4uw	5260	20	proteins	protein	NNS
cord-001835-0s7ok4uw	5260	21	for	for	IN
cord-001835-0s7ok4uw	5260	22	the	the	DT
cord-001835-0s7ok4uw	5260	23	initial	initial	JJ
cord-001835-0s7ok4uw	5260	24	step	step	NN
cord-001835-0s7ok4uw	5260	25	of	of	IN
cord-001835-0s7ok4uw	5260	26	transcription	transcription	NN
cord-001835-0s7ok4uw	5260	27	that	that	WDT
cord-001835-0s7ok4uw	5260	28	recognize	recognize	VBP
cord-001835-0s7ok4uw	5260	29	and	and	CC
cord-001835-0s7ok4uw	5260	30	bind	bind	VB
cord-001835-0s7ok4uw	5260	31	to	to	IN
cord-001835-0s7ok4uw	5260	32	promoter	promoter	NN
cord-001835-0s7ok4uw	5260	33	DNA	DNA	NNP
cord-001835-0s7ok4uw	5260	34	.	.	.
cord-001835-0s7ok4uw	5261	1	The	the	DT
cord-001835-0s7ok4uw	5261	2	primary	primary	JJ
cord-001835-0s7ok4uw	5261	3	sigma	sigma	NN
cord-001835-0s7ok4uw	5261	4	factor	factor	NN
cord-001835-0s7ok4uw	5261	5	is	be	VBZ
cord-001835-0s7ok4uw	5261	6	essential	essential	JJ
cord-001835-0s7ok4uw	5261	7	in	in	IN
cord-001835-0s7ok4uw	5261	8	exponential	exponential	JJ
cord-001835-0s7ok4uw	5261	9	phase	phase	NN
cord-001835-0s7ok4uw	5261	10	of	of	IN
cord-001835-0s7ok4uw	5261	11	growth	growth	NN
cord-001835-0s7ok4uw	5261	12	while	while	IN
cord-001835-0s7ok4uw	5261	13	alternative	alternative	JJ
cord-001835-0s7ok4uw	5261	14	sigma	sigma	NN
cord-001835-0s7ok4uw	5261	15	factors	factor	NNS
cord-001835-0s7ok4uw	5261	16	are	be	VBP
cord-001835-0s7ok4uw	5261	17	active	active	JJ
cord-001835-0s7ok4uw	5261	18	during	during	IN
cord-001835-0s7ok4uw	5261	19	transcription	transcription	NN
cord-001835-0s7ok4uw	5261	20	under	under	IN
cord-001835-0s7ok4uw	5261	21	stress	stress	NN
cord-001835-0s7ok4uw	5261	22	conditions	condition	NNS
cord-001835-0s7ok4uw	5261	23	.	.	.
cord-001835-0s7ok4uw	5262	1	This	this	DT
cord-001835-0s7ok4uw	5262	2	project	project	NN
cord-001835-0s7ok4uw	5262	3	has	have	VBZ
cord-001835-0s7ok4uw	5262	4	three	three	CD
cord-001835-0s7ok4uw	5262	5	main	main	JJ
cord-001835-0s7ok4uw	5262	6	aims	aim	NNS
cord-001835-0s7ok4uw	5262	7	.	.	.
cord-001835-0s7ok4uw	5263	1	The	the	DT
cord-001835-0s7ok4uw	5263	2	first	first	JJ
cord-001835-0s7ok4uw	5263	3	aim	aim	NN
cord-001835-0s7ok4uw	5263	4	is	be	VBZ
cord-001835-0s7ok4uw	5263	5	to	to	TO
cord-001835-0s7ok4uw	5263	6	explore	explore	VB
cord-001835-0s7ok4uw	5263	7	the	the	DT
cord-001835-0s7ok4uw	5263	8	binding	bind	VBG
cord-001835-0s7ok4uw	5263	9	properties	property	NNS
cord-001835-0s7ok4uw	5263	10	of	of	IN
cord-001835-0s7ok4uw	5263	11	B.	B.	NNP
cord-001835-0s7ok4uw	5263	12	subtilis	subtilis	NNP
cord-001835-0s7ok4uw	5263	13	alternative	alternative	JJ
cord-001835-0s7ok4uw	5263	14	sigma	sigma	NN
cord-001835-0s7ok4uw	5263	15	factors	factor	NNS
cord-001835-0s7ok4uw	5263	16	;	;	:
cord-001835-0s7ok4uw	5263	17	specifically	specifically	RB
cord-001835-0s7ok4uw	5263	18	,	,	,
cord-001835-0s7ok4uw	5263	19	whether	whether	IN
cord-001835-0s7ok4uw	5263	20	sigma	sigma	NN
cord-001835-0s7ok4uw	5263	21	factors	factor	NNS
cord-001835-0s7ok4uw	5263	22	lacking	lack	VBG
cord-001835-0s7ok4uw	5263	23	the	the	DT
cord-001835-0s7ok4uw	5263	24	autoinhibitory	autoinhibitory	JJ
cord-001835-0s7ok4uw	5263	25	domain	domain	NN
cord-001835-0s7ok4uw	5263	26	1.1	1.1	CD
cord-001835-0s7ok4uw	5263	27	can	can	MD
cord-001835-0s7ok4uw	5263	28	bind	bind	VB
cord-001835-0s7ok4uw	5263	29	to	to	IN
cord-001835-0s7ok4uw	5263	30	promoter	promoter	NN
cord-001835-0s7ok4uw	5263	31	DNA	dna	NN
cord-001835-0s7ok4uw	5263	32	in	in	IN
cord-001835-0s7ok4uw	5263	33	the	the	DT
cord-001835-0s7ok4uw	5263	34	absence	absence	NN
cord-001835-0s7ok4uw	5263	35	of	of	IN
cord-001835-0s7ok4uw	5263	36	RNAP	RNAP	NNP
cord-001835-0s7ok4uw	5263	37	.	.	.
cord-001835-0s7ok4uw	5264	1	The	the	DT
cord-001835-0s7ok4uw	5264	2	second	second	JJ
cord-001835-0s7ok4uw	5264	3	aim	aim	NN
cord-001835-0s7ok4uw	5264	4	explores	explore	VBZ
cord-001835-0s7ok4uw	5264	5	whether	whether	IN
cord-001835-0s7ok4uw	5264	6	RNAP	RNAP	NNP
cord-001835-0s7ok4uw	5264	7	associated	associate	VBN
cord-001835-0s7ok4uw	5264	8	with	with	IN
cord-001835-0s7ok4uw	5264	9	alternative	alternative	JJ
cord-001835-0s7ok4uw	5264	10	sigma	sigma	NN
cord-001835-0s7ok4uw	5264	11	factors	factor	NNS
cord-001835-0s7ok4uw	5264	12	is	be	VBZ
cord-001835-0s7ok4uw	5264	13	regulated	regulate	VBN
cord-001835-0s7ok4uw	5264	14	by	by	IN
cord-001835-0s7ok4uw	5264	15	the	the	DT
cord-001835-0s7ok4uw	5264	16	concentration	concentration	NN
cord-001835-0s7ok4uw	5264	17	of	of	IN
cord-001835-0s7ok4uw	5264	18	the	the	DT
cord-001835-0s7ok4uw	5264	19	initiation	initiation	NN
cord-001835-0s7ok4uw	5264	20	nucleoside	nucleoside	RB
cord-001835-0s7ok4uw	5264	21	triphosphate	triphosphate	NN
cord-001835-0s7ok4uw	5264	22	.	.	.
cord-001835-0s7ok4uw	5265	1	The	the	DT
cord-001835-0s7ok4uw	5265	2	third	third	JJ
cord-001835-0s7ok4uw	5265	3	aim	aim	NN
cord-001835-0s7ok4uw	5265	4	is	be	VBZ
cord-001835-0s7ok4uw	5265	5	to	to	TO
cord-001835-0s7ok4uw	5265	6	define	define	VB
cord-001835-0s7ok4uw	5265	7	the	the	DT
cord-001835-0s7ok4uw	5265	8	regulon	regulon	NN
cord-001835-0s7ok4uw	5265	9	of	of	IN
cord-001835-0s7ok4uw	5265	10	Sigma	Sigma	NNP
cord-001835-0s7ok4uw	5265	11	I.	I.	NNP
cord-001835-0s7ok4uw	5266	1	In	in	IN
cord-001835-0s7ok4uw	5266	2	order	order	NN
cord-001835-0s7ok4uw	5266	3	to	to	TO
cord-001835-0s7ok4uw	5266	4	achieve	achieve	VB
cord-001835-0s7ok4uw	5266	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5266	6	aims	aim	NNS
cord-001835-0s7ok4uw	5266	7	,	,	,
cord-001835-0s7ok4uw	5266	8	7	7	CD
cord-001835-0s7ok4uw	5266	9	out	out	IN
cord-001835-0s7ok4uw	5266	10	of	of	IN
cord-001835-0s7ok4uw	5266	11	17	17	CD
cord-001835-0s7ok4uw	5266	12	alternative	alternative	JJ
cord-001835-0s7ok4uw	5266	13	sigma	sigma	NN
cord-001835-0s7ok4uw	5266	14	factors	factor	NNS
cord-001835-0s7ok4uw	5266	15	were	be	VBD
cord-001835-0s7ok4uw	5266	16	successfully	successfully	RB
cord-001835-0s7ok4uw	5266	17	purified	purify	VBN
cord-001835-0s7ok4uw	5266	18	using	use	VBG
cord-001835-0s7ok4uw	5266	19	affinity	affinity	NN
cord-001835-0s7ok4uw	5266	20	chromatography	chromatography	NN
cord-001835-0s7ok4uw	5266	21	and	and	CC
cord-001835-0s7ok4uw	5266	22	ion	ion	NN
cord-001835-0s7ok4uw	5266	23	exchange	exchange	NN
cord-001835-0s7ok4uw	5266	24	chromatography	chromatography	NN
cord-001835-0s7ok4uw	5266	25	.	.	.
cord-001835-0s7ok4uw	5267	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5267	2	set	set	VBD
cord-001835-0s7ok4uw	5267	3	up	up	RP
cord-001835-0s7ok4uw	5267	4	in	in	IN
cord-001835-0s7ok4uw	5267	5	vitro	vitro	FW
cord-001835-0s7ok4uw	5267	6	transcription	transcription	NN
cord-001835-0s7ok4uw	5267	7	system	system	NN
cord-001835-0s7ok4uw	5267	8	with	with	IN
cord-001835-0s7ok4uw	5267	9	selected	select	VBN
cord-001835-0s7ok4uw	5267	10	sigma	sigma	NN
cord-001835-0s7ok4uw	5267	11	factors	factor	NNS
cord-001835-0s7ok4uw	5267	12	and	and	CC
cord-001835-0s7ok4uw	5267	13	initiated	initiate	VBN
cord-001835-0s7ok4uw	5267	14	experiments	experiment	NNS
cord-001835-0s7ok4uw	5267	15	with	with	IN
cord-001835-0s7ok4uw	5267	16	Sigma	Sigma	NNP
cord-001835-0s7ok4uw	5267	17	I	I	NNP
cord-001835-0s7ok4uw	5267	18	regulon	regulon	VBP
cord-001835-0s7ok4uw	5267	19	determination	determination	NN
cord-001835-0s7ok4uw	5267	20	.	.	.
cord-001835-0s7ok4uw	5268	1	Results	result	NNS
cord-001835-0s7ok4uw	5268	2	named	name	VBN
cord-001835-0s7ok4uw	5268	3	above	above	RB
cord-001835-0s7ok4uw	5268	4	and	and	CC
cord-001835-0s7ok4uw	5268	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5268	6	future	future	JJ
cord-001835-0s7ok4uw	5268	7	findings	finding	NNS
cord-001835-0s7ok4uw	5268	8	will	will	MD
cord-001835-0s7ok4uw	5268	9	help	help	VB
cord-001835-0s7ok4uw	5268	10	to	to	TO
cord-001835-0s7ok4uw	5268	11	better	better	RB
cord-001835-0s7ok4uw	5268	12	understand	understand	VB
cord-001835-0s7ok4uw	5268	13	gene	gene	NN
cord-001835-0s7ok4uw	5268	14	expression	expression	NN
cord-001835-0s7ok4uw	5268	15	regulation	regulation	NN
cord-001835-0s7ok4uw	5268	16	on	on	IN
cord-001835-0s7ok4uw	5268	17	the	the	DT
cord-001835-0s7ok4uw	5268	18	level	level	NN
cord-001835-0s7ok4uw	5268	19	of	of	IN
cord-001835-0s7ok4uw	5268	20	transcription	transcription	NN
cord-001835-0s7ok4uw	5268	21	initiation	initiation	NN
cord-001835-0s7ok4uw	5268	22	.	.	.
cord-001835-0s7ok4uw	5269	1	This	this	DT
cord-001835-0s7ok4uw	5269	2	work	work	NN
cord-001835-0s7ok4uw	5269	3	was	be	VBD
cord-001835-0s7ok4uw	5269	4	supported	support	VBN
cord-001835-0s7ok4uw	5269	5	by	by	IN
cord-001835-0s7ok4uw	5269	6	grant	grant	NN
cord-001835-0s7ok4uw	5269	7	No	no	NN
cord-001835-0s7ok4uw	5269	8	.	.	.
cord-001835-0s7ok4uw	5270	1	P305	P305	NNP
cord-001835-0s7ok4uw	5270	2	-	-	HYPH
cord-001835-0s7ok4uw	5270	3	12-G034	12-g034	CD
cord-001835-0s7ok4uw	5270	4	from	from	IN
cord-001835-0s7ok4uw	5270	5	the	the	DT
cord-001835-0s7ok4uw	5270	6	Czech	Czech	NNP
cord-001835-0s7ok4uw	5270	7	Science	Science	NNP
cord-001835-0s7ok4uw	5270	8	Foundation	Foundation	NNP
cord-001835-0s7ok4uw	5270	9	.	.	.
cord-001835-0s7ok4uw	5271	1	Assessing	assess	VBG
cord-001835-0s7ok4uw	5271	2	the	the	DT
cord-001835-0s7ok4uw	5271	3	costs	cost	NNS
cord-001835-0s7ok4uw	5271	4	and	and	CC
cord-001835-0s7ok4uw	5271	5	benefits	benefit	NNS
cord-001835-0s7ok4uw	5271	6	of	of	IN
cord-001835-0s7ok4uw	5271	7	protein	protein	NN
cord-001835-0s7ok4uw	5271	8	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5271	9	Protein	Protein	NNP
cord-001835-0s7ok4uw	5271	10	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5271	11	and	and	CC
cord-001835-0s7ok4uw	5271	12	cell	cell	NN
cord-001835-0s7ok4uw	5271	13	fitness	fitness	NN
cord-001835-0s7ok4uw	5271	14	Protein	Protein	NNP
cord-001835-0s7ok4uw	5271	15	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5271	16	has	have	VBZ
cord-001835-0s7ok4uw	5271	17	been	be	VBN
cord-001835-0s7ok4uw	5271	18	associated	associate	VBN
cord-001835-0s7ok4uw	5271	19	with	with	IN
cord-001835-0s7ok4uw	5271	20	numerous	numerous	JJ
cord-001835-0s7ok4uw	5271	21	diseases	disease	NNS
cord-001835-0s7ok4uw	5271	22	but	but	CC
cord-001835-0s7ok4uw	5271	23	also	also	RB
cord-001835-0s7ok4uw	5271	24	with	with	IN
cord-001835-0s7ok4uw	5271	25	important	important	JJ
cord-001835-0s7ok4uw	5271	26	cellular	cellular	JJ
cord-001835-0s7ok4uw	5271	27	functions	function	NNS
cord-001835-0s7ok4uw	5271	28	such	such	JJ
cord-001835-0s7ok4uw	5271	29	as	as	IN
cord-001835-0s7ok4uw	5271	30	epigenetic	epigenetic	JJ
cord-001835-0s7ok4uw	5271	31	inheritance	inheritance	NN
cord-001835-0s7ok4uw	5271	32	.	.	.
cord-001835-0s7ok4uw	5272	1	Here	here	RB
cord-001835-0s7ok4uw	5272	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	5272	3	present	present	VBP
cord-001835-0s7ok4uw	5272	4	a	a	DT
cord-001835-0s7ok4uw	5272	5	population	population	NN
cord-001835-0s7ok4uw	5272	6	genetics	genetics	NN
cord-001835-0s7ok4uw	5272	7	approach	approach	VBP
cord-001835-0s7ok4uw	5272	8	to	to	TO
cord-001835-0s7ok4uw	5272	9	infer	infer	VB
cord-001835-0s7ok4uw	5272	10	the	the	DT
cord-001835-0s7ok4uw	5272	11	costs	cost	NNS
cord-001835-0s7ok4uw	5272	12	and	and	CC
cord-001835-0s7ok4uw	5272	13	benefits	benefit	NNS
cord-001835-0s7ok4uw	5272	14	of	of	IN
cord-001835-0s7ok4uw	5272	15	protein	protein	NN
cord-001835-0s7ok4uw	5272	16	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5272	17	on	on	IN
cord-001835-0s7ok4uw	5272	18	cell	cell	NN
cord-001835-0s7ok4uw	5272	19	fitness	fitness	NN
cord-001835-0s7ok4uw	5272	20	.	.	.
cord-001835-0s7ok4uw	5273	1	This	this	DT
cord-001835-0s7ok4uw	5273	2	information	information	NN
cord-001835-0s7ok4uw	5273	3	is	be	VBZ
cord-001835-0s7ok4uw	5273	4	crucial	crucial	JJ
cord-001835-0s7ok4uw	5273	5	to	to	TO
cord-001835-0s7ok4uw	5273	6	understand	understand	VB
cord-001835-0s7ok4uw	5273	7	how	how	WRB
cord-001835-0s7ok4uw	5273	8	cellular	cellular	JJ
cord-001835-0s7ok4uw	5273	9	systems	system	NNS
cord-001835-0s7ok4uw	5273	10	tolerate	tolerate	VBP
cord-001835-0s7ok4uw	5273	11	the	the	DT
cord-001835-0s7ok4uw	5273	12	formation	formation	NN
cord-001835-0s7ok4uw	5273	13	of	of	IN
cord-001835-0s7ok4uw	5273	14	protein	protein	NN
cord-001835-0s7ok4uw	5273	15	deposits	deposit	NNS
cord-001835-0s7ok4uw	5273	16	and	and	CC
cord-001835-0s7ok4uw	5273	17	which	which	WDT
cord-001835-0s7ok4uw	5273	18	factors	factor	NNS
cord-001835-0s7ok4uw	5273	19	modulate	modulate	VBP
cord-001835-0s7ok4uw	5273	20	this	this	DT
cord-001835-0s7ok4uw	5273	21	event	event	NN
cord-001835-0s7ok4uw	5273	22	.	.	.
cord-001835-0s7ok4uw	5274	1	Using	use	VBG
cord-001835-0s7ok4uw	5274	2	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5274	3	experimental	experimental	JJ
cord-001835-0s7ok4uw	5274	4	system	system	NN
cord-001835-0s7ok4uw	5274	5	,	,	,
cord-001835-0s7ok4uw	5274	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	5274	7	measured	measure	VBD
cord-001835-0s7ok4uw	5274	8	different	different	JJ
cord-001835-0s7ok4uw	5274	9	protein	protein	NN
cord-001835-0s7ok4uw	5274	10	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5274	11	effects	effect	NNS
cord-001835-0s7ok4uw	5274	12	(	(	-LRB-
cord-001835-0s7ok4uw	5274	13	deleterious	deleterious	JJ
cord-001835-0s7ok4uw	5274	14	,	,	,
cord-001835-0s7ok4uw	5274	15	neutral	neutral	JJ
cord-001835-0s7ok4uw	5274	16	or	or	CC
cord-001835-0s7ok4uw	5274	17	beneficial	beneficial	JJ
cord-001835-0s7ok4uw	5274	18	)	)	-RRB-
cord-001835-0s7ok4uw	5274	19	within	within	IN
cord-001835-0s7ok4uw	5274	20	the	the	DT
cord-001835-0s7ok4uw	5274	21	same	same	JJ
cord-001835-0s7ok4uw	5274	22	genomic	genomic	JJ
cord-001835-0s7ok4uw	5274	23	background	background	NN
cord-001835-0s7ok4uw	5274	24	.	.	.
cord-001835-0s7ok4uw	5275	1	Single	single	JJ
cord-001835-0s7ok4uw	5275	2	cell	cell	NN
cord-001835-0s7ok4uw	5275	3	analyses	analysis	NNS
cord-001835-0s7ok4uw	5275	4	,	,	,
cord-001835-0s7ok4uw	5275	5	within	within	IN
cord-001835-0s7ok4uw	5275	6	the	the	DT
cord-001835-0s7ok4uw	5275	7	same	same	JJ
cord-001835-0s7ok4uw	5275	8	population	population	NN
cord-001835-0s7ok4uw	5275	9	,	,	,
cord-001835-0s7ok4uw	5275	10	showed	show	VBD
cord-001835-0s7ok4uw	5275	11	stochastic	stochastic	JJ
cord-001835-0s7ok4uw	5275	12	variability	variability	NN
cord-001835-0s7ok4uw	5275	13	in	in	IN
cord-001835-0s7ok4uw	5275	14	the	the	DT
cord-001835-0s7ok4uw	5275	15	aggregate	aggregate	NN
cord-001835-0s7ok4uw	5275	16	's	's	POS
cord-001835-0s7ok4uw	5275	17	size	size	NN
cord-001835-0s7ok4uw	5275	18	and	and	CC
cord-001835-0s7ok4uw	5275	19	in	in	IN
cord-001835-0s7ok4uw	5275	20	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5275	21	effect	effect	NN
cord-001835-0s7ok4uw	5275	22	on	on	IN
cord-001835-0s7ok4uw	5275	23	cell	cell	NN
cord-001835-0s7ok4uw	5275	24	fitness	fitness	NN
cord-001835-0s7ok4uw	5275	25	.	.	.
cord-001835-0s7ok4uw	5276	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	5276	2	data	data	NN
cord-001835-0s7ok4uw	5276	3	indicates	indicate	VBZ
cord-001835-0s7ok4uw	5276	4	that	that	IN
cord-001835-0s7ok4uw	5276	5	,	,	,
cord-001835-0s7ok4uw	5276	6	in	in	IN
cord-001835-0s7ok4uw	5276	7	certain	certain	JJ
cord-001835-0s7ok4uw	5276	8	conditions	condition	NNS
cord-001835-0s7ok4uw	5276	9	,	,	,
cord-001835-0s7ok4uw	5276	10	protein	protein	NN
cord-001835-0s7ok4uw	5276	11	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5276	12	can	can	MD
cord-001835-0s7ok4uw	5276	13	enhance	enhance	VB
cord-001835-0s7ok4uw	5276	14	population	population	NN
cord-001835-0s7ok4uw	5276	15	variability	variability	NN
cord-001835-0s7ok4uw	5276	16	and	and	CC
cord-001835-0s7ok4uw	5276	17	survival	survival	NN
cord-001835-0s7ok4uw	5276	18	expectancy	expectancy	NN
cord-001835-0s7ok4uw	5276	19	.	.	.
cord-001835-0s7ok4uw	5277	1	Overall	overall	RB
cord-001835-0s7ok4uw	5277	2	,	,	,
cord-001835-0s7ok4uw	5277	3	these	these	DT
cord-001835-0s7ok4uw	5277	4	results	result	NNS
cord-001835-0s7ok4uw	5277	5	suggest	suggest	VBP
cord-001835-0s7ok4uw	5277	6	that	that	IN
cord-001835-0s7ok4uw	5277	7	the	the	DT
cord-001835-0s7ok4uw	5277	8	presence	presence	NN
cord-001835-0s7ok4uw	5277	9	and	and	CC
cord-001835-0s7ok4uw	5277	10	formation	formation	NN
cord-001835-0s7ok4uw	5277	11	of	of	IN
cord-001835-0s7ok4uw	5277	12	protein	protein	NN
cord-001835-0s7ok4uw	5277	13	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	5277	14	could	could	MD
cord-001835-0s7ok4uw	5277	15	be	be	VB
cord-001835-0s7ok4uw	5277	16	almost	almost	RB
cord-001835-0s7ok4uw	5277	17	harmless	harmless	JJ
cord-001835-0s7ok4uw	5277	18	whereas	whereas	IN
cord-001835-0s7ok4uw	5277	19	the	the	DT
cord-001835-0s7ok4uw	5277	20	associated	associate	VBN
cord-001835-0s7ok4uw	5277	21	gain	gain	NN
cord-001835-0s7ok4uw	5277	22	and	and	CC
cord-001835-0s7ok4uw	5277	23	loss	loss	NN
cord-001835-0s7ok4uw	5277	24	of	of	IN
cord-001835-0s7ok4uw	5277	25	function	function	NN
cord-001835-0s7ok4uw	5277	26	are	be	VBP
cord-001835-0s7ok4uw	5277	27	critical	critical	JJ
cord-001835-0s7ok4uw	5277	28	for	for	IN
cord-001835-0s7ok4uw	5277	29	the	the	DT
cord-001835-0s7ok4uw	5277	30	cell	cell	NN
cord-001835-0s7ok4uw	5277	31	.	.	.
cord-001835-0s7ok4uw	5278	1	Revealing	reveal	VBG
cord-001835-0s7ok4uw	5278	2	the	the	DT
cord-001835-0s7ok4uw	5278	3	key	key	JJ
cord-001835-0s7ok4uw	5278	4	role	role	NN
cord-001835-0s7ok4uw	5278	5	of	of	IN
cord-001835-0s7ok4uw	5278	6	negatively	negatively	RB
cord-001835-0s7ok4uw	5278	7	charged	charge	VBN
cord-001835-0s7ok4uw	5278	8	residues	residue	NNS
cord-001835-0s7ok4uw	5278	9	of	of	IN
cord-001835-0s7ok4uw	5278	10	heme	heme	NN
cord-001835-0s7ok4uw	5278	11	sensor	sensor	NN
cord-001835-0s7ok4uw	5278	12	proteins	protein	NNS
cord-001835-0s7ok4uw	5278	13	involved	involve	VBN
cord-001835-0s7ok4uw	5278	14	in	in	IN
cord-001835-0s7ok4uw	5278	15	Geobacter	Geobacter	NNP
cord-001835-0s7ok4uw	5278	16	sulfurreducens	sulfurreducen	NNS
cord-001835-0s7ok4uw	5278	17	'	'	POS
cord-001835-0s7ok4uw	5278	18	signal	signal	NN
cord-001835-0s7ok4uw	5278	19	transduction	transduction	NN
cord-001835-0s7ok4uw	5278	20	pathways	pathway	NNS
cord-001835-0s7ok4uw	5279	1	Marta	Marta	NNP
cord-001835-0s7ok4uw	5279	2	A.	a.	NN
cord-001835-0s7ok4uw	5279	3	Silva	Silva	NNP
cord-001835-0s7ok4uw	5279	4	1	1	CD
cord-001835-0s7ok4uw	5279	5	,	,	,
cord-001835-0s7ok4uw	5279	6	Telma	Telma	NNP
cord-001835-0s7ok4uw	5279	7	C.	C.	NNP
cord-001835-0s7ok4uw	5279	8	Santos	Santos	NNP
cord-001835-0s7ok4uw	5279	9	1	1	CD
cord-001835-0s7ok4uw	5279	10	,	,	,
cord-001835-0s7ok4uw	5279	11	Teresa	Teresa	NNP
cord-001835-0s7ok4uw	5279	12	Catarino	Catarino	NNP
cord-001835-0s7ok4uw	5279	13	2	2	CD
cord-001835-0s7ok4uw	5279	14	,	,	,
cord-001835-0s7ok4uw	5279	15	Carlos	Carlos	NNP
cord-001835-0s7ok4uw	5279	16	A.	A.	NNP
cord-001835-0s7ok4uw	5279	17	Salgueiro	Salgueiro	NNP
cord-001835-0s7ok4uw	5279	18	1	1	CD
cord-001835-0s7ok4uw	5279	19	1	1	CD
cord-001835-0s7ok4uw	5279	20	UCIBIO	UCIBIO	NNP
cord-001835-0s7ok4uw	5279	21	-	-	HYPH
cord-001835-0s7ok4uw	5279	22	Requimte	Requimte	NNP
cord-001835-0s7ok4uw	5279	23	,	,	,
cord-001835-0s7ok4uw	5279	24	Departamento	Departamento	NNP
cord-001835-0s7ok4uw	5279	25	de	de	NNP
cord-001835-0s7ok4uw	5279	26	Qu	Qu	NNP
cord-001835-0s7ok4uw	5279	27	ımica	ımica	NNP
cord-001835-0s7ok4uw	5279	28	,	,	,
cord-001835-0s7ok4uw	5279	29	FCT	FCT	NNP
cord-001835-0s7ok4uw	5279	30	-	-	HYPH
cord-001835-0s7ok4uw	5279	31	UNL	UNL	NNP
cord-001835-0s7ok4uw	5279	32	.	.	.
cord-001835-0s7ok4uw	5279	33	,	,	,
cord-001835-0s7ok4uw	5280	1	2	2	LS
cord-001835-0s7ok4uw	5280	2	Instituto	Instituto	NNP
cord-001835-0s7ok4uw	5280	3	de	de	NNP
cord-001835-0s7ok4uw	5280	4	Tecnologia	Tecnologia	NNP
cord-001835-0s7ok4uw	5280	5	Qu	Qu	NNP
cord-001835-0s7ok4uw	5280	6	ımica	ımica	NN
cord-001835-0s7ok4uw	5280	7	e	e	NNP
cord-001835-0s7ok4uw	5280	8	Biol	Biol	NNP
cord-001835-0s7ok4uw	5280	9	ogica	ogica	NNP
cord-001835-0s7ok4uw	5280	10	,	,	,
cord-001835-0s7ok4uw	5280	11	UNL	UNL	NNP
cord-001835-0s7ok4uw	5280	12	Signal	Signal	NNP
cord-001835-0s7ok4uw	5280	13	transduction	transduction	NN
cord-001835-0s7ok4uw	5280	14	proteins	protein	NNS
cord-001835-0s7ok4uw	5281	1	Bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5281	2	chemotaxis	chemotaxis	NN
cord-001835-0s7ok4uw	5281	3	systems	system	NNS
cord-001835-0s7ok4uw	5281	4	sense	sense	NN
cord-001835-0s7ok4uw	5281	5	and	and	CC
cord-001835-0s7ok4uw	5281	6	regulate	regulate	VB
cord-001835-0s7ok4uw	5281	7	the	the	DT
cord-001835-0s7ok4uw	5281	8	microbe	microbe	NN
cord-001835-0s7ok4uw	5281	9	mobility	mobility	NN
cord-001835-0s7ok4uw	5281	10	in	in	IN
cord-001835-0s7ok4uw	5281	11	response	response	NN
cord-001835-0s7ok4uw	5281	12	to	to	IN
cord-001835-0s7ok4uw	5281	13	environmental	environmental	JJ
cord-001835-0s7ok4uw	5281	14	conditions	condition	NNS
cord-001835-0s7ok4uw	5281	15	.	.	.
cord-001835-0s7ok4uw	5282	1	Such	such	JJ
cord-001835-0s7ok4uw	5282	2	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	5282	3	constitute	constitute	VBP
cord-001835-0s7ok4uw	5282	4	a	a	DT
cord-001835-0s7ok4uw	5282	5	striking	striking	JJ
cord-001835-0s7ok4uw	5282	6	example	example	NN
cord-001835-0s7ok4uw	5282	7	of	of	IN
cord-001835-0s7ok4uw	5282	8	cell	cell	NN
cord-001835-0s7ok4uw	5282	9	motility	motility	NN
cord-001835-0s7ok4uw	5282	10	to	to	TO
cord-001835-0s7ok4uw	5282	11	gain	gain	VB
cord-001835-0s7ok4uw	5282	12	advantages	advantage	NNS
cord-001835-0s7ok4uw	5282	13	for	for	IN
cord-001835-0s7ok4uw	5282	14	cell	cell	NN
cord-001835-0s7ok4uw	5282	15	survival	survival	NN
cord-001835-0s7ok4uw	5282	16	and	and	CC
cord-001835-0s7ok4uw	5282	17	permit	permit	VB
cord-001835-0s7ok4uw	5282	18	the	the	DT
cord-001835-0s7ok4uw	5282	19	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	5282	20	to	to	TO
cord-001835-0s7ok4uw	5282	21	fill	fill	VB
cord-001835-0s7ok4uw	5282	22	important	important	JJ
cord-001835-0s7ok4uw	5282	23	niches	niche	NNS
cord-001835-0s7ok4uw	5282	24	in	in	IN
cord-001835-0s7ok4uw	5282	25	a	a	DT
cord-001835-0s7ok4uw	5282	26	diversity	diversity	NN
cord-001835-0s7ok4uw	5282	27	of	of	IN
cord-001835-0s7ok4uw	5282	28	anaerobic	anaerobic	JJ
cord-001835-0s7ok4uw	5282	29	environments	environment	NNS
cord-001835-0s7ok4uw	5282	30	[	[	-LRB-
cord-001835-0s7ok4uw	5282	31	1	1	CD
cord-001835-0s7ok4uw	5282	32	]	]	-RRB-
cord-001835-0s7ok4uw	5282	33	.	.	.
cord-001835-0s7ok4uw	5283	1	Geobacter	Geobacter	NNP
cord-001835-0s7ok4uw	5283	2	sulfurreducens	sulfurreducen	NNS
cord-001835-0s7ok4uw	5283	3	(	(	-LRB-
cord-001835-0s7ok4uw	5283	4	Gs	Gs	NNP
cord-001835-0s7ok4uw	5283	5	)	)	-RRB-
cord-001835-0s7ok4uw	5283	6	is	be	VBZ
cord-001835-0s7ok4uw	5283	7	an	an	DT
cord-001835-0s7ok4uw	5283	8	anaerobic	anaerobic	JJ
cord-001835-0s7ok4uw	5283	9	bacterium	bacterium	NN
cord-001835-0s7ok4uw	5283	10	with	with	IN
cord-001835-0s7ok4uw	5283	11	a	a	DT
cord-001835-0s7ok4uw	5283	12	considerable	considerable	JJ
cord-001835-0s7ok4uw	5283	13	respiratory	respiratory	JJ
cord-001835-0s7ok4uw	5283	14	versatility	versatility	NN
cord-001835-0s7ok4uw	5283	15	whose	whose	WP$
cord-001835-0s7ok4uw	5283	16	genome	genome	NN
cord-001835-0s7ok4uw	5283	17	encodes	encode	VBZ
cord-001835-0s7ok4uw	5283	18	for	for	IN
cord-001835-0s7ok4uw	5283	19	an	an	DT
cord-001835-0s7ok4uw	5283	20	unusual	unusual	JJ
cord-001835-0s7ok4uw	5283	21	family	family	NN
cord-001835-0s7ok4uw	5283	22	of	of	IN
cord-001835-0s7ok4uw	5283	23	methyl	methyl	NN
cord-001835-0s7ok4uw	5283	24	-	-	HYPH
cord-001835-0s7ok4uw	5283	25	accepting	accept	VBG
cord-001835-0s7ok4uw	5283	26	chemotaxis	chemotaxis	NN
cord-001835-0s7ok4uw	5283	27	proteins	protein	NNS
cord-001835-0s7ok4uw	5283	28	(	(	-LRB-
cord-001835-0s7ok4uw	5283	29	MCP	MCP	NNP
cord-001835-0s7ok4uw	5283	30	)	)	-RRB-
cord-001835-0s7ok4uw	5283	31	,	,	,
cord-001835-0s7ok4uw	5283	32	each	each	DT
cord-001835-0s7ok4uw	5283	33	containing	contain	VBG
cord-001835-0s7ok4uw	5283	34	at	at	RB
cord-001835-0s7ok4uw	5283	35	least	least	RBS
cord-001835-0s7ok4uw	5283	36	one	one	CD
cord-001835-0s7ok4uw	5283	37	heme	heme	NN
cord-001835-0s7ok4uw	5283	38	c	c	NN
cord-001835-0s7ok4uw	5283	39	-	-	HYPH
cord-001835-0s7ok4uw	5283	40	binding	bind	VBG
cord-001835-0s7ok4uw	5283	41	motif	motif	NN
cord-001835-0s7ok4uw	5283	42	[	[	-LRB-
cord-001835-0s7ok4uw	5283	43	2	2	CD
cord-001835-0s7ok4uw	5283	44	]	]	-RRB-
cord-001835-0s7ok4uw	5283	45	.	.	.
cord-001835-0s7ok4uw	5284	1	These	these	DT
cord-001835-0s7ok4uw	5284	2	sensor	sensor	NN
cord-001835-0s7ok4uw	5284	3	proteins	protein	NNS
cord-001835-0s7ok4uw	5284	4	,	,	,
cord-001835-0s7ok4uw	5284	5	GSU0582	GSU0582	NNP
cord-001835-0s7ok4uw	5284	6	and	and	CC
cord-001835-0s7ok4uw	5284	7	GSU0935	gsu0935	NN
cord-001835-0s7ok4uw	5284	8	,	,	,
cord-001835-0s7ok4uw	5284	9	are	be	VBP
cord-001835-0s7ok4uw	5284	10	involved	involve	VBN
cord-001835-0s7ok4uw	5284	11	in	in	IN
cord-001835-0s7ok4uw	5284	12	signal	signal	NN
cord-001835-0s7ok4uw	5284	13	transduction	transduction	NN
cord-001835-0s7ok4uw	5284	14	pathways	pathway	NNS
cord-001835-0s7ok4uw	5284	15	mediated	mediate	VBN
cord-001835-0s7ok4uw	5284	16	by	by	IN
cord-001835-0s7ok4uw	5284	17	chemotaxis	chemotaxis	NN
cord-001835-0s7ok4uw	5284	18	-	-	HYPH
cord-001835-0s7ok4uw	5284	19	like	like	JJ
cord-001835-0s7ok4uw	5284	20	systems	system	NNS
cord-001835-0s7ok4uw	5284	21	[	[	-LRB-
cord-001835-0s7ok4uw	5284	22	3	3	CD
cord-001835-0s7ok4uw	5284	23	]	]	-RRB-
cord-001835-0s7ok4uw	5284	24	.	.	.
cord-001835-0s7ok4uw	5285	1	The	the	DT
cord-001835-0s7ok4uw	5285	2	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	5285	3	and	and	CC
cord-001835-0s7ok4uw	5285	4	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	5285	5	characterization	characterization	NN
cord-001835-0s7ok4uw	5285	6	of	of	IN
cord-001835-0s7ok4uw	5285	7	the	the	DT
cord-001835-0s7ok4uw	5285	8	sensors	sensor	NNS
cord-001835-0s7ok4uw	5285	9	GSU0582	GSU0582	VBG
cord-001835-0s7ok4uw	5285	10	and	and	CC
cord-001835-0s7ok4uw	5285	11	GSU0935	gsu0935	NN
cord-001835-0s7ok4uw	5285	12	by	by	IN
cord-001835-0s7ok4uw	5285	13	visible	visible	JJ
cord-001835-0s7ok4uw	5285	14	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	5285	15	and	and	CC
cord-001835-0s7ok4uw	5285	16	stopped	stop	VBN
cord-001835-0s7ok4uw	5285	17	-	-	HYPH
cord-001835-0s7ok4uw	5285	18	flow	flow	NN
cord-001835-0s7ok4uw	5285	19	techniques	technique	NNS
cord-001835-0s7ok4uw	5285	20	,	,	,
cord-001835-0s7ok4uw	5285	21	at	at	IN
cord-001835-0s7ok4uw	5285	22	several	several	JJ
cord-001835-0s7ok4uw	5285	23	pH	ph	NN
cord-001835-0s7ok4uw	5285	24	and	and	CC
cord-001835-0s7ok4uw	5285	25	ionic	ionic	JJ
cord-001835-0s7ok4uw	5285	26	strength	strength	NN
cord-001835-0s7ok4uw	5285	27	values	value	NNS
cord-001835-0s7ok4uw	5285	28	revealed	reveal	VBD
cord-001835-0s7ok4uw	5285	29	that	that	IN
cord-001835-0s7ok4uw	5285	30	sensor	sensor	NN
cord-001835-0s7ok4uw	5285	31	GSU0935	gsu0935	NN
cord-001835-0s7ok4uw	5285	32	midpoint	midpoint	NN
cord-001835-0s7ok4uw	5285	33	reduction	reduction	NN
cord-001835-0s7ok4uw	5285	34	potentials	potential	NNS
cord-001835-0s7ok4uw	5285	35	are	be	VBP
cord-001835-0s7ok4uw	5285	36	lower	low	JJR
cord-001835-0s7ok4uw	5285	37	than	than	IN
cord-001835-0s7ok4uw	5285	38	those	those	DT
cord-001835-0s7ok4uw	5285	39	of	of	IN
cord-001835-0s7ok4uw	5285	40	GSU0582	GSU0582	VBG
cord-001835-0s7ok4uw	5285	41	at	at	RB
cord-001835-0s7ok4uw	5285	42	all	all	RB
cord-001835-0s7ok4uw	5285	43	pH	pH	NNP
cord-001835-0s7ok4uw	5285	44	and	and	CC
cord-001835-0s7ok4uw	5285	45	ionic	ionic	JJ
cord-001835-0s7ok4uw	5285	46	strength	strength	NN
cord-001835-0s7ok4uw	5285	47	values	value	NNS
cord-001835-0s7ok4uw	5285	48	and	and	CC
cord-001835-0s7ok4uw	5285	49	the	the	DT
cord-001835-0s7ok4uw	5285	50	same	same	JJ
cord-001835-0s7ok4uw	5285	51	were	be	VBD
cord-001835-0s7ok4uw	5285	52	observed	observe	VBN
cord-001835-0s7ok4uw	5285	53	for	for	IN
cord-001835-0s7ok4uw	5285	54	the	the	DT
cord-001835-0s7ok4uw	5285	55	reduction	reduction	NN
cord-001835-0s7ok4uw	5285	56	rate	rate	NN
cord-001835-0s7ok4uw	5285	57	constants	constant	NNS
cord-001835-0s7ok4uw	5285	58	[	[	-LRB-
cord-001835-0s7ok4uw	5285	59	4	4	CD
cord-001835-0s7ok4uw	5285	60	]	]	-RRB-
cord-001835-0s7ok4uw	5285	61	.	.	.
cord-001835-0s7ok4uw	5286	1	The	the	DT
cord-001835-0s7ok4uw	5286	2	origin	origin	NN
cord-001835-0s7ok4uw	5286	3	of	of	IN
cord-001835-0s7ok4uw	5286	4	the	the	DT
cord-001835-0s7ok4uw	5286	5	different	different	JJ
cord-001835-0s7ok4uw	5286	6	functional	functional	JJ
cord-001835-0s7ok4uw	5286	7	properties	property	NNS
cord-001835-0s7ok4uw	5286	8	of	of	IN
cord-001835-0s7ok4uw	5286	9	these	these	DT
cord-001835-0s7ok4uw	5286	10	closely	closely	RB
cord-001835-0s7ok4uw	5286	11	related	related	JJ
cord-001835-0s7ok4uw	5286	12	sensor	sensor	NN
cord-001835-0s7ok4uw	5286	13	domains	domain	NNS
cord-001835-0s7ok4uw	5286	14	are	be	VBP
cord-001835-0s7ok4uw	5286	15	rationalized	rationalize	VBN
cord-001835-0s7ok4uw	5286	16	in	in	IN
cord-001835-0s7ok4uw	5286	17	the	the	DT
cord-001835-0s7ok4uw	5286	18	structural	structural	JJ
cord-001835-0s7ok4uw	5286	19	terms	term	NNS
cord-001835-0s7ok4uw	5286	20	showing	show	VBG
cord-001835-0s7ok4uw	5286	21	that	that	IN
cord-001835-0s7ok4uw	5286	22	GSU0935	GSU0935	NNP
cord-001835-0s7ok4uw	5286	23	has	have	VBZ
cord-001835-0s7ok4uw	5286	24	two	two	CD
cord-001835-0s7ok4uw	5286	25	extra	extra	RB
cord-001835-0s7ok4uw	5286	26	negatively	negatively	RB
cord-001835-0s7ok4uw	5286	27	charged	charge	VBN
cord-001835-0s7ok4uw	5286	28	residues	residue	NNS
cord-001835-0s7ok4uw	5286	29	in	in	IN
cord-001835-0s7ok4uw	5286	30	the	the	DT
cord-001835-0s7ok4uw	5286	31	vicinity	vicinity	NN
cord-001835-0s7ok4uw	5286	32	of	of	IN
cord-001835-0s7ok4uw	5286	33	the	the	DT
cord-001835-0s7ok4uw	5286	34	heme	heme	NN
cord-001835-0s7ok4uw	5286	35	group	group	NN
cord-001835-0s7ok4uw	5286	36	,	,	,
cord-001835-0s7ok4uw	5286	37	which	which	WDT
cord-001835-0s7ok4uw	5286	38	have	have	VBP
cord-001835-0s7ok4uw	5286	39	no	no	DT
cord-001835-0s7ok4uw	5286	40	counterpart	counterpart	NN
cord-001835-0s7ok4uw	5286	41	in	in	IN
cord-001835-0s7ok4uw	5286	42	GSU0582	GSU0582	NNP
cord-001835-0s7ok4uw	5286	43	:	:	:
cord-001835-0s7ok4uw	5286	44	Glu89	Glu89	NNP
cord-001835-0s7ok4uw	5286	45	and	and	CC
cord-001835-0s7ok4uw	5286	46	Asp57	Asp57	NNP
cord-001835-0s7ok4uw	5286	47	.	.	.
cord-001835-0s7ok4uw	5287	1	Residue	Residue	NNP
cord-001835-0s7ok4uw	5287	2	Asp57	Asp57	NNP
cord-001835-0s7ok4uw	5287	3	is	be	VBZ
cord-001835-0s7ok4uw	5287	4	less	less	RBR
cord-001835-0s7ok4uw	5287	5	exposed	expose	VBN
cord-001835-0s7ok4uw	5287	6	compared	compare	VBN
cord-001835-0s7ok4uw	5287	7	to	to	IN
cord-001835-0s7ok4uw	5287	8	Glu89	Glu89	NNP
cord-001835-0s7ok4uw	5288	1	and	and	CC
cord-001835-0s7ok4uw	5288	2	it	-PRON-	PRP
cord-001835-0s7ok4uw	5288	3	was	be	VBD
cord-001835-0s7ok4uw	5288	4	suggested	suggest	VBN
cord-001835-0s7ok4uw	5288	5	that	that	IN
cord-001835-0s7ok4uw	5288	6	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5288	7	carboxylic	carboxylic	JJ
cord-001835-0s7ok4uw	5288	8	group	group	NN
cord-001835-0s7ok4uw	5288	9	might	may	MD
cord-001835-0s7ok4uw	5288	10	have	have	VB
cord-001835-0s7ok4uw	5288	11	a	a	DT
cord-001835-0s7ok4uw	5288	12	role	role	NN
cord-001835-0s7ok4uw	5288	13	in	in	IN
cord-001835-0s7ok4uw	5288	14	the	the	DT
cord-001835-0s7ok4uw	5288	15	modulation	modulation	NN
cord-001835-0s7ok4uw	5288	16	of	of	IN
cord-001835-0s7ok4uw	5288	17	the	the	DT
cord-001835-0s7ok4uw	5288	18	heme	heme	NN
cord-001835-0s7ok4uw	5288	19	reduction	reduction	NN
cord-001835-0s7ok4uw	5288	20	potential	potential	NN
cord-001835-0s7ok4uw	5288	21	of	of	IN
cord-001835-0s7ok4uw	5288	22	GSU0935	GSU0935	NNP
cord-001835-0s7ok4uw	5288	23	.	.	.
cord-001835-0s7ok4uw	5289	1	To	to	TO
cord-001835-0s7ok4uw	5289	2	investigate	investigate	VB
cord-001835-0s7ok4uw	5289	3	this	this	DT
cord-001835-0s7ok4uw	5289	4	,	,	,
cord-001835-0s7ok4uw	5289	5	both	both	DT
cord-001835-0s7ok4uw	5289	6	residues	residue	NNS
cord-001835-0s7ok4uw	5289	7	were	be	VBD
cord-001835-0s7ok4uw	5289	8	replaced	replace	VBN
cord-001835-0s7ok4uw	5289	9	by	by	IN
cord-001835-0s7ok4uw	5289	10	a	a	DT
cord-001835-0s7ok4uw	5289	11	positively	positively	RB
cord-001835-0s7ok4uw	5289	12	charged	charge	VBN
cord-001835-0s7ok4uw	5289	13	amino	amino	NN
cord-001835-0s7ok4uw	5289	14	acid	acid	NN
cord-001835-0s7ok4uw	5289	15	(	(	-LRB-
cord-001835-0s7ok4uw	5289	16	lysine	lysine	NN
cord-001835-0s7ok4uw	5289	17	)	)	-RRB-
cord-001835-0s7ok4uw	5289	18	and	and	CC
cord-001835-0s7ok4uw	5289	19	by	by	IN
cord-001835-0s7ok4uw	5289	20	a	a	DT
cord-001835-0s7ok4uw	5289	21	neutral	neutral	JJ
cord-001835-0s7ok4uw	5289	22	one	one	CD
cord-001835-0s7ok4uw	5289	23	(	(	-LRB-
cord-001835-0s7ok4uw	5289	24	asparagine	asparagine	NN
cord-001835-0s7ok4uw	5289	25	or	or	CC
cord-001835-0s7ok4uw	5289	26	glutamine	glutamine	NN
cord-001835-0s7ok4uw	5289	27	)	)	-RRB-
cord-001835-0s7ok4uw	5289	28	.	.	.
cord-001835-0s7ok4uw	5290	1	For	for	IN
cord-001835-0s7ok4uw	5290	2	the	the	DT
cord-001835-0s7ok4uw	5290	3	mutants	mutant	NNS
cord-001835-0s7ok4uw	5290	4	with	with	IN
cord-001835-0s7ok4uw	5290	5	enough	enough	JJ
cord-001835-0s7ok4uw	5290	6	expression	expression	NN
cord-001835-0s7ok4uw	5290	7	,	,	,
cord-001835-0s7ok4uw	5290	8	a	a	DT
cord-001835-0s7ok4uw	5290	9	functional	functional	JJ
cord-001835-0s7ok4uw	5290	10	characterization	characterization	NN
cord-001835-0s7ok4uw	5290	11	was	be	VBD
cord-001835-0s7ok4uw	5290	12	carry	carry	VB
cord-001835-0s7ok4uw	5290	13	out	out	RP
cord-001835-0s7ok4uw	5290	14	,	,	,
cord-001835-0s7ok4uw	5290	15	using	use	VBG
cord-001835-0s7ok4uw	5290	16	several	several	JJ
cord-001835-0s7ok4uw	5290	17	spectroscopic	spectroscopic	JJ
cord-001835-0s7ok4uw	5290	18	techniques	technique	NNS
cord-001835-0s7ok4uw	5290	19	,	,	,
cord-001835-0s7ok4uw	5290	20	including	include	VBG
cord-001835-0s7ok4uw	5290	21	UV	uv	NN
cord-001835-0s7ok4uw	5290	22	-	-	HYPH
cord-001835-0s7ok4uw	5290	23	visible	visible	JJ
cord-001835-0s7ok4uw	5290	24	and	and	CC
cord-001835-0s7ok4uw	5290	25	CD	CD	NNP
cord-001835-0s7ok4uw	5290	26	,	,	,
cord-001835-0s7ok4uw	5290	27	together	together	RB
cord-001835-0s7ok4uw	5290	28	with	with	IN
cord-001835-0s7ok4uw	5290	29	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	5290	30	and	and	CC
cord-001835-0s7ok4uw	5290	31	potentiometric	potentiometric	JJ
cord-001835-0s7ok4uw	5290	32	measurements	measurement	NNS
cord-001835-0s7ok4uw	5290	33	.	.	.
cord-001835-0s7ok4uw	5291	1	Significant	significant	JJ
cord-001835-0s7ok4uw	5291	2	changes	change	NNS
cord-001835-0s7ok4uw	5291	3	on	on	IN
cord-001835-0s7ok4uw	5291	4	the	the	DT
cord-001835-0s7ok4uw	5291	5	reduction	reduction	NN
cord-001835-0s7ok4uw	5291	6	potential	potential	JJ
cord-001835-0s7ok4uw	5291	7	values	value	NNS
cord-001835-0s7ok4uw	5291	8	are	be	VBP
cord-001835-0s7ok4uw	5291	9	observed	observe	VBN
cord-001835-0s7ok4uw	5291	10	when	when	WRB
cord-001835-0s7ok4uw	5291	11	a	a	DT
cord-001835-0s7ok4uw	5291	12	negative	negative	JJ
cord-001835-0s7ok4uw	5291	13	charge	charge	NN
cord-001835-0s7ok4uw	5291	14	is	be	VBZ
cord-001835-0s7ok4uw	5291	15	replaced	replace	VBN
cord-001835-0s7ok4uw	5291	16	by	by	IN
cord-001835-0s7ok4uw	5291	17	a	a	DT
cord-001835-0s7ok4uw	5291	18	positive	positive	JJ
cord-001835-0s7ok4uw	5291	19	one	one	NN
cord-001835-0s7ok4uw	5291	20	at	at	IN
cord-001835-0s7ok4uw	5291	21	position	position	NN
cord-001835-0s7ok4uw	5291	22	57	57	CD
cord-001835-0s7ok4uw	5291	23	or	or	CC
cord-001835-0s7ok4uw	5291	24	89	89	CD
cord-001835-0s7ok4uw	5291	25	.	.	.
cord-001835-0s7ok4uw	5292	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	5292	2	,	,	,
cord-001835-0s7ok4uw	5292	3	the	the	DT
cord-001835-0s7ok4uw	5292	4	decrease	decrease	NN
cord-001835-0s7ok4uw	5292	5	of	of	IN
cord-001835-0s7ok4uw	5292	6	the	the	DT
cord-001835-0s7ok4uw	5292	7	reduction	reduction	NN
cord-001835-0s7ok4uw	5292	8	potential	potential	NN
cord-001835-0s7ok4uw	5292	9	in	in	IN
cord-001835-0s7ok4uw	5292	10	Asp57	Asp57	NNP
cord-001835-0s7ok4uw	5292	11	and	and	CC
cord-001835-0s7ok4uw	5292	12	Glu89	Glu89	NNP
cord-001835-0s7ok4uw	5292	13	mutants	mutant	NNS
cord-001835-0s7ok4uw	5292	14	reinforces	reinforce	VBZ
cord-001835-0s7ok4uw	5292	15	the	the	DT
cord-001835-0s7ok4uw	5292	16	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	5292	17	that	that	IN
cord-001835-0s7ok4uw	5292	18	the	the	DT
cord-001835-0s7ok4uw	5292	19	higher	high	JJR
cord-001835-0s7ok4uw	5292	20	reduction	reduction	NN
cord-001835-0s7ok4uw	5292	21	potential	potential	NN
cord-001835-0s7ok4uw	5292	22	observed	observe	VBD
cord-001835-0s7ok4uw	5292	23	for	for	IN
cord-001835-0s7ok4uw	5292	24	heme	heme	NN
cord-001835-0s7ok4uw	5292	25	sensor	sensor	NN
cord-001835-0s7ok4uw	5292	26	domain	domain	NN
cord-001835-0s7ok4uw	5292	27	GSU0582	GSU0582	NNP
cord-001835-0s7ok4uw	5292	28	is	be	VBZ
cord-001835-0s7ok4uw	5292	29	related	relate	VBN
cord-001835-0s7ok4uw	5292	30	with	with	IN
cord-001835-0s7ok4uw	5292	31	the	the	DT
cord-001835-0s7ok4uw	5292	32	less	less	RBR
cord-001835-0s7ok4uw	5292	33	negative	negative	JJ
cord-001835-0s7ok4uw	5292	34	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	5292	35	surface	surface	NN
cord-001835-0s7ok4uw	5292	36	around	around	IN
cord-001835-0s7ok4uw	5292	37	the	the	DT
cord-001835-0s7ok4uw	5292	38	heme	heme	NN
cord-001835-0s7ok4uw	5292	39	.	.	.
cord-001835-0s7ok4uw	5293	1	This	this	DT
cord-001835-0s7ok4uw	5293	2	work	work	NN
cord-001835-0s7ok4uw	5293	3	provides	provide	VBZ
cord-001835-0s7ok4uw	5293	4	,	,	,
cord-001835-0s7ok4uw	5293	5	for	for	IN
cord-001835-0s7ok4uw	5293	6	the	the	DT
cord-001835-0s7ok4uw	5293	7	first	first	JJ
cord-001835-0s7ok4uw	5293	8	time	time	NN
cord-001835-0s7ok4uw	5293	9	,	,	,
cord-001835-0s7ok4uw	5293	10	evidence	evidence	NN
cord-001835-0s7ok4uw	5293	11	for	for	IN
cord-001835-0s7ok4uw	5293	12	the	the	DT
cord-001835-0s7ok4uw	5293	13	co	co	NN
cord-001835-0s7ok4uw	5293	14	-	-	NN
cord-001835-0s7ok4uw	5293	15	existence	existence	NN
cord-001835-0s7ok4uw	5293	16	of	of	IN
cord-001835-0s7ok4uw	5293	17	two	two	CD
cord-001835-0s7ok4uw	5293	18	similar	similar	JJ
cord-001835-0s7ok4uw	5293	19	methyl	methyl	NN
cord-001835-0s7ok4uw	5293	20	-	-	HYPH
cord-001835-0s7ok4uw	5293	21	accepting	accept	VBG
cord-001835-0s7ok4uw	5293	22	chemotaxis	chemotaxis	NN
cord-001835-0s7ok4uw	5293	23	proteins	protein	NNS
cord-001835-0s7ok4uw	5293	24	functioning	function	VBG
cord-001835-0s7ok4uw	5293	25	in	in	IN
cord-001835-0s7ok4uw	5293	26	different	different	JJ
cord-001835-0s7ok4uw	5293	27	working	work	VBG
cord-001835-0s7ok4uw	5293	28	potential	potential	JJ
cord-001835-0s7ok4uw	5293	29	ranges	range	NNS
cord-001835-0s7ok4uw	5293	30	.	.	.
cord-001835-0s7ok4uw	5294	1	These	these	DT
cord-001835-0s7ok4uw	5294	2	proteins	protein	NNS
cord-001835-0s7ok4uw	5294	3	are	be	VBP
cord-001835-0s7ok4uw	5294	4	responsible	responsible	JJ
cord-001835-0s7ok4uw	5294	5	to	to	TO
cord-001835-0s7ok4uw	5294	6	allow	allow	VB
cord-001835-0s7ok4uw	5294	7	Geobacter	Geobacter	NNP
cord-001835-0s7ok4uw	5294	8	sulfurreducens	sulfurreducen	NNS
cord-001835-0s7ok4uw	5294	9	triggering	trigger	VBG
cord-001835-0s7ok4uw	5294	10	an	an	DT
cord-001835-0s7ok4uw	5294	11	adequate	adequate	JJ
cord-001835-0s7ok4uw	5294	12	cellular	cellular	JJ
cord-001835-0s7ok4uw	5294	13	response	response	NN
cord-001835-0s7ok4uw	5294	14	in	in	IN
cord-001835-0s7ok4uw	5294	15	different	different	JJ
cord-001835-0s7ok4uw	5294	16	anoxic	anoxic	JJ
cord-001835-0s7ok4uw	5294	17	subsurface	subsurface	NN
cord-001835-0s7ok4uw	5294	18	environments	environment	NNS
cord-001835-0s7ok4uw	5294	19	.	.	.
cord-001835-0s7ok4uw	5295	1	1	1	CD
cord-001835-0s7ok4uw	5295	2	National	National	NNP
cord-001835-0s7ok4uw	5295	3	Autonomous	Autonomous	NNP
cord-001835-0s7ok4uw	5295	4	University	University	NNP
cord-001835-0s7ok4uw	5295	5	of	of	IN
cord-001835-0s7ok4uw	5295	6	Mexico	Mexico	NNP
cord-001835-0s7ok4uw	5295	7	,	,	,
cord-001835-0s7ok4uw	5295	8	Faculty	Faculty	NNP
cord-001835-0s7ok4uw	5295	9	of	of	IN
cord-001835-0s7ok4uw	5295	10	Medicine	Medicine	NNP
cord-001835-0s7ok4uw	5295	11	,	,	,
cord-001835-0s7ok4uw	5295	12	2	2	CD
cord-001835-0s7ok4uw	5295	13	National	National	NNP
cord-001835-0s7ok4uw	5295	14	Autonomous	Autonomous	NNP
cord-001835-0s7ok4uw	5295	15	University	University	NNP
cord-001835-0s7ok4uw	5295	16	of	of	IN
cord-001835-0s7ok4uw	5295	17	Mexico	Mexico	NNP
cord-001835-0s7ok4uw	5295	18	,	,	,
cord-001835-0s7ok4uw	5295	19	Faculty	Faculty	NNP
cord-001835-0s7ok4uw	5295	20	of	of	IN
cord-001835-0s7ok4uw	5295	21	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	5295	22	,	,	,
cord-001835-0s7ok4uw	5295	23	3	3	CD
cord-001835-0s7ok4uw	5295	24	National	National	NNP
cord-001835-0s7ok4uw	5295	25	Autonomous	Autonomous	NNP
cord-001835-0s7ok4uw	5295	26	University	University	NNP
cord-001835-0s7ok4uw	5295	27	of	of	IN
cord-001835-0s7ok4uw	5295	28	Mexico	Mexico	NNP
cord-001835-0s7ok4uw	5295	29	,	,	,
cord-001835-0s7ok4uw	5295	30	Institute	Institute	NNP
cord-001835-0s7ok4uw	5295	31	of	of	IN
cord-001835-0s7ok4uw	5295	32	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	5296	1	Molecular	molecular	JJ
cord-001835-0s7ok4uw	5296	2	Evolution	evolution	NN
cord-001835-0s7ok4uw	5297	1	The	the	DT
cord-001835-0s7ok4uw	5297	2	glycolytic	glycolytic	JJ
cord-001835-0s7ok4uw	5297	3	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5297	4	triosephosphate	triosephosphate	NN
cord-001835-0s7ok4uw	5297	5	isomerase	isomerase	NN
cord-001835-0s7ok4uw	5297	6	(	(	-LRB-
cord-001835-0s7ok4uw	5297	7	TIM	TIM	NNP
cord-001835-0s7ok4uw	5297	8	)	)	-RRB-
cord-001835-0s7ok4uw	5297	9	is	be	VBZ
cord-001835-0s7ok4uw	5297	10	an	an	DT
cord-001835-0s7ok4uw	5297	11	oligomeric	oligomeric	JJ
cord-001835-0s7ok4uw	5297	12	(	(	-LRB-
cord-001835-0s7ok4uw	5297	13	b	b	NN
cord-001835-0s7ok4uw	5297	14	/	/	SYM
cord-001835-0s7ok4uw	5297	15	alpha)8	alpha)8	NN
cord-001835-0s7ok4uw	5297	16	barrel	barrel	NN
cord-001835-0s7ok4uw	5297	17	that	that	WDT
cord-001835-0s7ok4uw	5297	18	catalyses	catalyse	VBZ
cord-001835-0s7ok4uw	5297	19	the	the	DT
cord-001835-0s7ok4uw	5297	20	interconversion	interconversion	NN
cord-001835-0s7ok4uw	5297	21	of	of	IN
cord-001835-0s7ok4uw	5297	22	D	D	NNP
cord-001835-0s7ok4uw	5297	23	-	-	:
cord-001835-0s7ok4uw	5297	24	Glyceraldehyde	Glyceraldehyde	NNP
cord-001835-0s7ok4uw	5297	25	3-phosphate	3-phosphate	CD
cord-001835-0s7ok4uw	5297	26	and	and	CC
cord-001835-0s7ok4uw	5297	27	dihydroxyacetone	dihydroxyacetone	NN
cord-001835-0s7ok4uw	5297	28	phosphate	phosphate	NN
cord-001835-0s7ok4uw	5297	29	in	in	IN
cord-001835-0s7ok4uw	5297	30	a	a	DT
cord-001835-0s7ok4uw	5297	31	diffusion	diffusion	NN
cord-001835-0s7ok4uw	5297	32	-	-	HYPH
cord-001835-0s7ok4uw	5297	33	limited	limit	VBN
cord-001835-0s7ok4uw	5297	34	reaction	reaction	NN
cord-001835-0s7ok4uw	5297	35	.	.	.
cord-001835-0s7ok4uw	5298	1	Although	although	IN
cord-001835-0s7ok4uw	5298	2	each	each	DT
cord-001835-0s7ok4uw	5298	3	subunit	subunit	NN
cord-001835-0s7ok4uw	5298	4	has	have	VBZ
cord-001835-0s7ok4uw	5298	5	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5298	6	own	own	JJ
cord-001835-0s7ok4uw	5298	7	active	active	JJ
cord-001835-0s7ok4uw	5298	8	site	site	NN
cord-001835-0s7ok4uw	5298	9	,	,	,
cord-001835-0s7ok4uw	5298	10	naturally	naturally	RB
cord-001835-0s7ok4uw	5298	11	occurring	occur	VBG
cord-001835-0s7ok4uw	5298	12	monomeric	monomeric	JJ
cord-001835-0s7ok4uw	5298	13	TIMs	tim	NNS
cord-001835-0s7ok4uw	5298	14	have	have	VBP
cord-001835-0s7ok4uw	5298	15	not	not	RB
cord-001835-0s7ok4uw	5298	16	been	be	VBN
cord-001835-0s7ok4uw	5298	17	reported	report	VBN
cord-001835-0s7ok4uw	5298	18	;	;	:
cord-001835-0s7ok4uw	5298	19	in	in	IN
cord-001835-0s7ok4uw	5298	20	fact	fact	NN
cord-001835-0s7ok4uw	5298	21	,	,	,
cord-001835-0s7ok4uw	5298	22	monomer	monomer	NN
cord-001835-0s7ok4uw	5298	23	association	association	NN
cord-001835-0s7ok4uw	5298	24	is	be	VBZ
cord-001835-0s7ok4uw	5298	25	very	very	RB
cord-001835-0s7ok4uw	5298	26	tight	tight	JJ
cord-001835-0s7ok4uw	5298	27	.	.	.
cord-001835-0s7ok4uw	5299	1	TIM	TIM	NNP
cord-001835-0s7ok4uw	5299	2	topology	topology	NN
cord-001835-0s7ok4uw	5299	3	is	be	VBZ
cord-001835-0s7ok4uw	5299	4	well	well	RB
cord-001835-0s7ok4uw	5299	5	conserved	conserve	VBN
cord-001835-0s7ok4uw	5299	6	among	among	IN
cord-001835-0s7ok4uw	5299	7	the	the	DT
cord-001835-0s7ok4uw	5299	8	three	three	CD
cord-001835-0s7ok4uw	5299	9	domains	domain	NNS
cord-001835-0s7ok4uw	5299	10	of	of	IN
cord-001835-0s7ok4uw	5299	11	life	life	NN
cord-001835-0s7ok4uw	5299	12	.	.	.
cord-001835-0s7ok4uw	5300	1	Nevertheless	nevertheless	RB
cord-001835-0s7ok4uw	5300	2	,	,	,
cord-001835-0s7ok4uw	5300	3	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5300	4	folding	folding	NN
cord-001835-0s7ok4uw	5300	5	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5300	6	and	and	CC
cord-001835-0s7ok4uw	5300	7	inhibition	inhibition	NN
cord-001835-0s7ok4uw	5300	8	properties	property	NNS
cord-001835-0s7ok4uw	5300	9	vary	vary	VBP
cord-001835-0s7ok4uw	5300	10	across	across	IN
cord-001835-0s7ok4uw	5300	11	species	specie	NNS
cord-001835-0s7ok4uw	5300	12	.	.	.
cord-001835-0s7ok4uw	5301	1	Comparative	comparative	JJ
cord-001835-0s7ok4uw	5301	2	studies	study	NNS
cord-001835-0s7ok4uw	5301	3	of	of	IN
cord-001835-0s7ok4uw	5301	4	proteins	protein	NNS
cord-001835-0s7ok4uw	5301	5	have	have	VBP
cord-001835-0s7ok4uw	5301	6	proved	prove	VBN
cord-001835-0s7ok4uw	5301	7	to	to	TO
cord-001835-0s7ok4uw	5301	8	be	be	VB
cord-001835-0s7ok4uw	5301	9	very	very	RB
cord-001835-0s7ok4uw	5301	10	useful	useful	JJ
cord-001835-0s7ok4uw	5301	11	in	in	IN
cord-001835-0s7ok4uw	5301	12	understanding	understand	VBG
cord-001835-0s7ok4uw	5301	13	the	the	DT
cord-001835-0s7ok4uw	5301	14	relationship	relationship	NN
cord-001835-0s7ok4uw	5301	15	between	between	IN
cord-001835-0s7ok4uw	5301	16	sequence	sequence	NN
cord-001835-0s7ok4uw	5301	17	and	and	CC
cord-001835-0s7ok4uw	5301	18	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	5301	19	properties	property	NNS
cord-001835-0s7ok4uw	5301	20	,	,	,
cord-001835-0s7ok4uw	5301	21	however	however	RB
cord-001835-0s7ok4uw	5301	22	,	,	,
cord-001835-0s7ok4uw	5301	23	they	-PRON-	PRP
cord-001835-0s7ok4uw	5301	24	lack	lack	VBP
cord-001835-0s7ok4uw	5301	25	the	the	DT
cord-001835-0s7ok4uw	5301	26	capacity	capacity	NN
cord-001835-0s7ok4uw	5301	27	to	to	TO
cord-001835-0s7ok4uw	5301	28	give	give	VB
cord-001835-0s7ok4uw	5301	29	a	a	DT
cord-001835-0s7ok4uw	5301	30	more	more	RBR
cord-001835-0s7ok4uw	5301	31	integrative	integrative	JJ
cord-001835-0s7ok4uw	5301	32	and	and	CC
cord-001835-0s7ok4uw	5301	33	evolutive	evolutive	JJ
cord-001835-0s7ok4uw	5301	34	correlation	correlation	NN
cord-001835-0s7ok4uw	5301	35	.	.	.
cord-001835-0s7ok4uw	5302	1	In	in	IN
cord-001835-0s7ok4uw	5302	2	order	order	NN
cord-001835-0s7ok4uw	5302	3	to	to	TO
cord-001835-0s7ok4uw	5302	4	elucidate	elucidate	VB
cord-001835-0s7ok4uw	5302	5	how	how	WRB
cord-001835-0s7ok4uw	5302	6	the	the	DT
cord-001835-0s7ok4uw	5302	7	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5302	8	properties	property	NNS
cord-001835-0s7ok4uw	5302	9	,	,	,
cord-001835-0s7ok4uw	5302	10	the	the	DT
cord-001835-0s7ok4uw	5302	11	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	5302	12	state	state	NN
cord-001835-0s7ok4uw	5302	13	and	and	CC
cord-001835-0s7ok4uw	5302	14	the	the	DT
cord-001835-0s7ok4uw	5302	15	stability	stability	NN
cord-001835-0s7ok4uw	5302	16	of	of	IN
cord-001835-0s7ok4uw	5302	17	extant	extant	JJ
cord-001835-0s7ok4uw	5302	18	TIMs	tim	NNS
cord-001835-0s7ok4uw	5302	19	arose	arise	VBD
cord-001835-0s7ok4uw	5302	20	,	,	,
cord-001835-0s7ok4uw	5302	21	in	in	IN
cord-001835-0s7ok4uw	5302	22	this	this	DT
cord-001835-0s7ok4uw	5302	23	work	work	NN
cord-001835-0s7ok4uw	5302	24	we	-PRON-	PRP
cord-001835-0s7ok4uw	5302	25	examined	examine	VBD
cord-001835-0s7ok4uw	5302	26	the	the	DT
cord-001835-0s7ok4uw	5302	27	molecular	molecular	JJ
cord-001835-0s7ok4uw	5302	28	history	history	NN
cord-001835-0s7ok4uw	5302	29	of	of	IN
cord-001835-0s7ok4uw	5302	30	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	5302	31	TIM	TIM	NNP
cord-001835-0s7ok4uw	5302	32	through	through	IN
cord-001835-0s7ok4uw	5302	33	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	5302	34	protein	protein	NN
cord-001835-0s7ok4uw	5302	35	reconstruction	reconstruction	NN
cord-001835-0s7ok4uw	5302	36	methods	method	NNS
cord-001835-0s7ok4uw	5302	37	(	(	-LRB-
cord-001835-0s7ok4uw	5302	38	Maximum	Maximum	NNP
cord-001835-0s7ok4uw	5302	39	Likelihood	Likelihood	NNP
cord-001835-0s7ok4uw	5302	40	)	)	-RRB-
cord-001835-0s7ok4uw	5302	41	and	and	CC
cord-001835-0s7ok4uw	5302	42	the	the	DT
cord-001835-0s7ok4uw	5302	43	subsequent	subsequent	JJ
cord-001835-0s7ok4uw	5302	44	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	5302	45	characterization	characterization	NN
cord-001835-0s7ok4uw	5302	46	of	of	IN
cord-001835-0s7ok4uw	5302	47	the	the	DT
cord-001835-0s7ok4uw	5302	48	resurrected	resurrect	VBN
cord-001835-0s7ok4uw	5302	49	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5302	50	.	.	.
cord-001835-0s7ok4uw	5303	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5303	2	first	first	RB
cord-001835-0s7ok4uw	5303	3	characterized	characterize	VBD
cord-001835-0s7ok4uw	5303	4	in	in	IN
cord-001835-0s7ok4uw	5303	5	detail	detail	NN
cord-001835-0s7ok4uw	5303	6	the	the	DT
cord-001835-0s7ok4uw	5303	7	protein	protein	NN
cord-001835-0s7ok4uw	5303	8	corresponding	correspond	VBG
cord-001835-0s7ok4uw	5303	9	to	to	IN
cord-001835-0s7ok4uw	5303	10	the	the	DT
cord-001835-0s7ok4uw	5303	11	last	last	JJ
cord-001835-0s7ok4uw	5303	12	common	common	JJ
cord-001835-0s7ok4uw	5303	13	ancestor	ancestor	NN
cord-001835-0s7ok4uw	5303	14	of	of	IN
cord-001835-0s7ok4uw	5303	15	animals	animal	NNS
cord-001835-0s7ok4uw	5303	16	and	and	CC
cord-001835-0s7ok4uw	5303	17	fungi	fungus	NNS
cord-001835-0s7ok4uw	5303	18	(	(	-LRB-
cord-001835-0s7ok4uw	5303	19	TIM63	TIM63	NNP
cord-001835-0s7ok4uw	5303	20	)	)	-RRB-
cord-001835-0s7ok4uw	5303	21	.	.	.
cord-001835-0s7ok4uw	5304	1	The	the	DT
cord-001835-0s7ok4uw	5304	2	CD	cd	NN
cord-001835-0s7ok4uw	5304	3	and	and	CC
cord-001835-0s7ok4uw	5304	4	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	5304	5	spectra	spectrum	NNS
cord-001835-0s7ok4uw	5304	6	of	of	IN
cord-001835-0s7ok4uw	5304	7	TIM63	TIM63	NNP
cord-001835-0s7ok4uw	5304	8	are	be	VBP
cord-001835-0s7ok4uw	5304	9	similar	similar	JJ
cord-001835-0s7ok4uw	5304	10	to	to	IN
cord-001835-0s7ok4uw	5304	11	those	those	DT
cord-001835-0s7ok4uw	5304	12	of	of	IN
cord-001835-0s7ok4uw	5304	13	extant	extant	JJ
cord-001835-0s7ok4uw	5304	14	TIMs	tim	NNS
cord-001835-0s7ok4uw	5304	15	.	.	.
cord-001835-0s7ok4uw	5305	1	Secondary	secondary	JJ
cord-001835-0s7ok4uw	5305	2	structure	structure	NN
cord-001835-0s7ok4uw	5305	3	is	be	VBZ
cord-001835-0s7ok4uw	5305	4	lost	lose	VBN
cord-001835-0s7ok4uw	5305	5	in	in	IN
cord-001835-0s7ok4uw	5305	6	a	a	DT
cord-001835-0s7ok4uw	5305	7	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	5305	8	transition	transition	NN
cord-001835-0s7ok4uw	5305	9	with	with	IN
cord-001835-0s7ok4uw	5305	10	Tm	Tm	NNP
cord-001835-0s7ok4uw	5305	11	5	5	CD
cord-001835-0s7ok4uw	5306	1	68.78C.	68.78c.	CD
cord-001835-0s7ok4uw	5307	1	The	the	DT
cord-001835-0s7ok4uw	5307	2	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5307	3	loses	lose	VBZ
cord-001835-0s7ok4uw	5307	4	activity	activity	NN
cord-001835-0s7ok4uw	5307	5	upon	upon	IN
cord-001835-0s7ok4uw	5307	6	dilution	dilution	NN
cord-001835-0s7ok4uw	5307	7	suggesting	suggest	VBG
cord-001835-0s7ok4uw	5307	8	that	that	IN
cord-001835-0s7ok4uw	5307	9	only	only	RB
cord-001835-0s7ok4uw	5307	10	the	the	DT
cord-001835-0s7ok4uw	5307	11	dimer	dimer	NN
cord-001835-0s7ok4uw	5307	12	is	be	VBZ
cord-001835-0s7ok4uw	5307	13	active	active	JJ
cord-001835-0s7ok4uw	5307	14	.	.	.
cord-001835-0s7ok4uw	5308	1	Dilution	dilution	NN
cord-001835-0s7ok4uw	5308	2	experiments	experiment	NNS
cord-001835-0s7ok4uw	5308	3	followed	follow	VBN
cord-001835-0s7ok4uw	5308	4	by	by	IN
cord-001835-0s7ok4uw	5308	5	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	5308	6	titration	titration	NN
cord-001835-0s7ok4uw	5308	7	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	5308	8	indicate	indicate	VBP
cord-001835-0s7ok4uw	5308	9	that	that	IN
cord-001835-0s7ok4uw	5308	10	dissociation	dissociation	NN
cord-001835-0s7ok4uw	5308	11	enthalpy	enthalpy	NN
cord-001835-0s7ok4uw	5308	12	is	be	VBZ
cord-001835-0s7ok4uw	5308	13	small	small	JJ
cord-001835-0s7ok4uw	5308	14	;	;	:
cord-001835-0s7ok4uw	5308	15	moreover	moreover	RB
cord-001835-0s7ok4uw	5308	16	the	the	DT
cord-001835-0s7ok4uw	5308	17	heat	heat	NN
cord-001835-0s7ok4uw	5308	18	capacity	capacity	NN
cord-001835-0s7ok4uw	5308	19	change	change	NN
cord-001835-0s7ok4uw	5308	20	observed	observe	VBN
cord-001835-0s7ok4uw	5308	21	is	be	VBZ
cord-001835-0s7ok4uw	5308	22	three	three	CD
cord-001835-0s7ok4uw	5308	23	times	time	NNS
cord-001835-0s7ok4uw	5308	24	higher	high	JJR
cord-001835-0s7ok4uw	5308	25	than	than	IN
cord-001835-0s7ok4uw	5308	26	the	the	DT
cord-001835-0s7ok4uw	5308	27	one	one	NN
cord-001835-0s7ok4uw	5308	28	predicted	predict	VBD
cord-001835-0s7ok4uw	5308	29	for	for	IN
cord-001835-0s7ok4uw	5308	30	a	a	DT
cord-001835-0s7ok4uw	5308	31	rigid	rigid	JJ
cord-001835-0s7ok4uw	5308	32	body	body	NN
cord-001835-0s7ok4uw	5308	33	dissociation	dissociation	NN
cord-001835-0s7ok4uw	5308	34	process	process	NN
cord-001835-0s7ok4uw	5308	35	,	,	,
cord-001835-0s7ok4uw	5308	36	suggesting	suggest	VBG
cord-001835-0s7ok4uw	5308	37	partial	partial	JJ
cord-001835-0s7ok4uw	5308	38	unfolding	unfolding	NN
cord-001835-0s7ok4uw	5308	39	of	of	IN
cord-001835-0s7ok4uw	5308	40	the	the	DT
cord-001835-0s7ok4uw	5308	41	monomers	monomer	NNS
cord-001835-0s7ok4uw	5308	42	.	.	.
cord-001835-0s7ok4uw	5309	1	When	when	WRB
cord-001835-0s7ok4uw	5309	2	compared	compare	VBN
cord-001835-0s7ok4uw	5309	3	with	with	IN
cord-001835-0s7ok4uw	5309	4	extant	extant	JJ
cord-001835-0s7ok4uw	5309	5	TIMs	tim	NNS
cord-001835-0s7ok4uw	5309	6	,	,	,
cord-001835-0s7ok4uw	5309	7	the	the	DT
cord-001835-0s7ok4uw	5309	8	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5309	9	efficiency	efficiency	NN
cord-001835-0s7ok4uw	5309	10	of	of	IN
cord-001835-0s7ok4uw	5309	11	TIM63	TIM63	NNP
cord-001835-0s7ok4uw	5309	12	is	be	VBZ
cord-001835-0s7ok4uw	5309	13	reduced	reduce	VBN
cord-001835-0s7ok4uw	5309	14	10-fold	10-fold	JJ
cord-001835-0s7ok4uw	5309	15	,	,	,
cord-001835-0s7ok4uw	5309	16	whereas	whereas	IN
cord-001835-0s7ok4uw	5309	17	binding	bind	VBG
cord-001835-0s7ok4uw	5309	18	of	of	IN
cord-001835-0s7ok4uw	5309	19	PGH	PGH	NNP
cord-001835-0s7ok4uw	5309	20	,	,	,
cord-001835-0s7ok4uw	5309	21	a	a	DT
cord-001835-0s7ok4uw	5309	22	transition	transition	NN
cord-001835-0s7ok4uw	5309	23	-	-	HYPH
cord-001835-0s7ok4uw	5309	24	state	state	NN
cord-001835-0s7ok4uw	5309	25	analogue	analogue	NN
cord-001835-0s7ok4uw	5309	26	,	,	,
cord-001835-0s7ok4uw	5309	27	shows	show	VBZ
cord-001835-0s7ok4uw	5309	28	a	a	DT
cord-001835-0s7ok4uw	5309	29	similar	similar	JJ
cord-001835-0s7ok4uw	5309	30	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	5309	31	signature	signature	NN
cord-001835-0s7ok4uw	5309	32	.	.	.
cord-001835-0s7ok4uw	5310	1	These	these	DT
cord-001835-0s7ok4uw	5310	2	data	datum	NNS
cord-001835-0s7ok4uw	5310	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	5310	4	that	that	IN
cord-001835-0s7ok4uw	5310	5	although	although	IN
cord-001835-0s7ok4uw	5310	6	monomer	monomer	NNP
cord-001835-0s7ok4uw	5310	7	association	association	NNP
cord-001835-0s7ok4uw	5310	8	may	may	MD
cord-001835-0s7ok4uw	5310	9	have	have	VB
cord-001835-0s7ok4uw	5310	10	been	be	VBN
cord-001835-0s7ok4uw	5310	11	less	less	RBR
cord-001835-0s7ok4uw	5310	12	tight	tight	JJ
cord-001835-0s7ok4uw	5310	13	in	in	IN
cord-001835-0s7ok4uw	5310	14	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	5310	15	TIMs	TIMs	NNPS
cord-001835-0s7ok4uw	5310	16	,	,	,
cord-001835-0s7ok4uw	5310	17	catalysis	catalysis	NN
cord-001835-0s7ok4uw	5310	18	has	have	VBZ
cord-001835-0s7ok4uw	5310	19	been	be	VBN
cord-001835-0s7ok4uw	5310	20	always	always	RB
cord-001835-0s7ok4uw	5310	21	linked	link	VBN
cord-001835-0s7ok4uw	5310	22	to	to	IN
cord-001835-0s7ok4uw	5310	23	oligomerization	oligomerization	NN
cord-001835-0s7ok4uw	5310	24	.	.	.
cord-001835-0s7ok4uw	5311	1	Analysis	analysis	NN
cord-001835-0s7ok4uw	5311	2	of	of	IN
cord-001835-0s7ok4uw	5311	3	the	the	DT
cord-001835-0s7ok4uw	5311	4	crystal	crystal	JJ
cord-001835-0s7ok4uw	5311	5	structure	structure	NN
cord-001835-0s7ok4uw	5311	6	of	of	IN
cord-001835-0s7ok4uw	5311	7	TIM63	TIM63	NNP
cord-001835-0s7ok4uw	5311	8	,	,	,
cord-001835-0s7ok4uw	5311	9	obtained	obtain	VBN
cord-001835-0s7ok4uw	5311	10	at	at	IN
cord-001835-0s7ok4uw	5311	11	1.9	1.9	CD
cord-001835-0s7ok4uw	5311	12	Å	å	NN
cord-001835-0s7ok4uw	5311	13	resolution	resolution	NN
cord-001835-0s7ok4uw	5311	14	,	,	,
cord-001835-0s7ok4uw	5311	15	suggests	suggest	VBZ
cord-001835-0s7ok4uw	5311	16	that	that	IN
cord-001835-0s7ok4uw	5311	17	the	the	DT
cord-001835-0s7ok4uw	5311	18	lack	lack	NN
cord-001835-0s7ok4uw	5311	19	of	of	IN
cord-001835-0s7ok4uw	5311	20	four	four	CD
cord-001835-0s7ok4uw	5311	21	salt	salt	NN
cord-001835-0s7ok4uw	5311	22	bridges	bridge	NNS
cord-001835-0s7ok4uw	5311	23	observed	observe	VBN
cord-001835-0s7ok4uw	5311	24	in	in	IN
cord-001835-0s7ok4uw	5311	25	the	the	DT
cord-001835-0s7ok4uw	5311	26	interface	interface	NN
cord-001835-0s7ok4uw	5311	27	of	of	IN
cord-001835-0s7ok4uw	5311	28	extant	extant	JJ
cord-001835-0s7ok4uw	5311	29	TIMs	tim	NNS
cord-001835-0s7ok4uw	5311	30	is	be	VBZ
cord-001835-0s7ok4uw	5311	31	responsible	responsible	JJ
cord-001835-0s7ok4uw	5311	32	for	for	IN
cord-001835-0s7ok4uw	5311	33	the	the	DT
cord-001835-0s7ok4uw	5311	34	low	low	JJ
cord-001835-0s7ok4uw	5311	35	dimer	dimer	NN
cord-001835-0s7ok4uw	5311	36	stability	stability	NN
cord-001835-0s7ok4uw	5311	37	.	.	.
cord-001835-0s7ok4uw	5312	1	In	in	IN
cord-001835-0s7ok4uw	5312	2	order	order	NN
cord-001835-0s7ok4uw	5312	3	to	to	TO
cord-001835-0s7ok4uw	5312	4	test	test	VB
cord-001835-0s7ok4uw	5312	5	this	this	DT
cord-001835-0s7ok4uw	5312	6	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	5312	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	5312	8	also	also	RB
cord-001835-0s7ok4uw	5312	9	studied	study	VBD
cord-001835-0s7ok4uw	5312	10	the	the	DT
cord-001835-0s7ok4uw	5312	11	stability	stability	NN
cord-001835-0s7ok4uw	5312	12	of	of	IN
cord-001835-0s7ok4uw	5312	13	four	four	CD
cord-001835-0s7ok4uw	5312	14	younger	young	JJR
cord-001835-0s7ok4uw	5312	15	reconstructed	reconstruct	VBN
cord-001835-0s7ok4uw	5312	16	ancestors	ancestor	NNS
cord-001835-0s7ok4uw	5312	17	that	that	WDT
cord-001835-0s7ok4uw	5312	18	acquired	acquire	VBD
cord-001835-0s7ok4uw	5312	19	the	the	DT
cord-001835-0s7ok4uw	5312	20	salt	salt	NN
cord-001835-0s7ok4uw	5312	21	bridges	bridge	NNS
cord-001835-0s7ok4uw	5312	22	in	in	IN
cord-001835-0s7ok4uw	5312	23	two	two	CD
cord-001835-0s7ok4uw	5312	24	different	different	JJ
cord-001835-0s7ok4uw	5312	25	phylogenetic	phylogenetic	JJ
cord-001835-0s7ok4uw	5312	26	lineages	lineage	NNS
cord-001835-0s7ok4uw	5312	27	.	.	.
cord-001835-0s7ok4uw	5313	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5313	2	found	find	VBD
cord-001835-0s7ok4uw	5313	3	a	a	DT
cord-001835-0s7ok4uw	5313	4	correlation	correlation	NN
cord-001835-0s7ok4uw	5313	5	between	between	IN
cord-001835-0s7ok4uw	5313	6	the	the	DT
cord-001835-0s7ok4uw	5313	7	appearance	appearance	NN
cord-001835-0s7ok4uw	5313	8	of	of	IN
cord-001835-0s7ok4uw	5313	9	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	5313	10	interactions	interaction	NNS
cord-001835-0s7ok4uw	5313	11	in	in	IN
cord-001835-0s7ok4uw	5313	12	the	the	DT
cord-001835-0s7ok4uw	5313	13	interface	interface	NN
cord-001835-0s7ok4uw	5313	14	,	,	,
cord-001835-0s7ok4uw	5313	15	dimer	dimer	NN
cord-001835-0s7ok4uw	5313	16	stability	stability	NN
cord-001835-0s7ok4uw	5313	17	and	and	CC
cord-001835-0s7ok4uw	5313	18	catalysis	catalysis	NN
cord-001835-0s7ok4uw	5313	19	;	;	,
cord-001835-0s7ok4uw	5313	20	suggesting	suggest	VBG
cord-001835-0s7ok4uw	5313	21	that	that	IN
cord-001835-0s7ok4uw	5313	22	these	these	DT
cord-001835-0s7ok4uw	5313	23	salt	salt	NN
cord-001835-0s7ok4uw	5313	24	bridges	bridge	NNS
cord-001835-0s7ok4uw	5313	25	are	be	VBP
cord-001835-0s7ok4uw	5313	26	partially	partially	RB
cord-001835-0s7ok4uw	5313	27	responsible	responsible	JJ
cord-001835-0s7ok4uw	5313	28	for	for	IN
cord-001835-0s7ok4uw	5313	29	extant	extant	JJ
cord-001835-0s7ok4uw	5313	30	dimer	dimer	NN
cord-001835-0s7ok4uw	5313	31	stability	stability	NN
cord-001835-0s7ok4uw	5313	32	and	and	CC
cord-001835-0s7ok4uw	5313	33	shed	shed	VBD
cord-001835-0s7ok4uw	5313	34	light	light	NN
cord-001835-0s7ok4uw	5313	35	on	on	IN
cord-001835-0s7ok4uw	5313	36	the	the	DT
cord-001835-0s7ok4uw	5313	37	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	5313	38	nature	nature	NN
cord-001835-0s7ok4uw	5313	39	of	of	IN
cord-001835-0s7ok4uw	5313	40	extant	extant	JJ
cord-001835-0s7ok4uw	5313	41	TIMs	tim	NNS
cord-001835-0s7ok4uw	5313	42	.	.	.
cord-001835-0s7ok4uw	5314	1	Receptor	receptor	NN
cord-001835-0s7ok4uw	5314	2	protein	protein	NN
cord-001835-0s7ok4uw	5314	3	-	-	HYPH
cord-001835-0s7ok4uw	5314	4	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5314	5	phosphatases	phosphatase	NNS
cord-001835-0s7ok4uw	5314	6	:	:	:
cord-001835-0s7ok4uw	5314	7	dimerization	dimerization	NN
cord-001835-0s7ok4uw	5314	8	,	,	,
cord-001835-0s7ok4uw	5314	9	receptor	receptor	NN
cord-001835-0s7ok4uw	5314	10	kinase	kinase	VBZ
cord-001835-0s7ok4uw	5314	11	interaction	interaction	NN
cord-001835-0s7ok4uw	5314	12	and	and	CC
cord-001835-0s7ok4uw	5314	13	allosteric	allosteric	JJ
cord-001835-0s7ok4uw	5314	14	modulation	modulation	NN
cord-001835-0s7ok4uw	5315	1	Elizabeth	Elizabeth	NNP
cord-001835-0s7ok4uw	5315	2	Dembicer	Dembicer	NNP
cord-001835-0s7ok4uw	5315	3	1	1	CD
cord-001835-0s7ok4uw	5315	4	,	,	,
cord-001835-0s7ok4uw	5315	5	Damien	Damien	NNP
cord-001835-0s7ok4uw	5315	6	Thevenin	Thevenin	NNP
cord-001835-0s7ok4uw	5315	7	1	1	CD
cord-001835-0s7ok4uw	5315	8	1	1	CD
cord-001835-0s7ok4uw	5315	9	Department	Department	NNP
cord-001835-0s7ok4uw	5315	10	of	of	IN
cord-001835-0s7ok4uw	5315	11	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	5315	12	,	,	,
cord-001835-0s7ok4uw	5316	1	Lehigh	Lehigh	NNP
cord-001835-0s7ok4uw	5316	2	University	University	NNP
cord-001835-0s7ok4uw	5316	3	THEME	theme	NN
cord-001835-0s7ok4uw	5316	4	:	:	:
cord-001835-0s7ok4uw	5317	1	receptor	receptor	NN
cord-001835-0s7ok4uw	5317	2	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5317	3	kinase	kinase	NN
cord-001835-0s7ok4uw	5317	4	and	and	CC
cord-001835-0s7ok4uw	5317	5	receptor	receptor	NN
cord-001835-0s7ok4uw	5317	6	protein	protein	NN
cord-001835-0s7ok4uw	5317	7	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	5317	8	signaling	signal	VBG
cord-001835-0s7ok4uw	5317	9	Many	many	JJ
cord-001835-0s7ok4uw	5317	10	cell	cell	NN
cord-001835-0s7ok4uw	5317	11	-	-	HYPH
cord-001835-0s7ok4uw	5317	12	signaling	signal	VBG
cord-001835-0s7ok4uw	5317	13	events	event	NNS
cord-001835-0s7ok4uw	5317	14	are	be	VBP
cord-001835-0s7ok4uw	5317	15	regulated	regulate	VBN
cord-001835-0s7ok4uw	5317	16	through	through	IN
cord-001835-0s7ok4uw	5317	17	reversible	reversible	JJ
cord-001835-0s7ok4uw	5317	18	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5317	19	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	5317	20	of	of	IN
cord-001835-0s7ok4uw	5317	21	proteins	protein	NNS
cord-001835-0s7ok4uw	5317	22	,	,	,
cord-001835-0s7ok4uw	5317	23	which	which	WDT
cord-001835-0s7ok4uw	5317	24	is	be	VBZ
cord-001835-0s7ok4uw	5317	25	controlled	control	VBN
cord-001835-0s7ok4uw	5317	26	by	by	IN
cord-001835-0s7ok4uw	5317	27	the	the	DT
cord-001835-0s7ok4uw	5317	28	counterbalanced	counterbalanced	JJ
cord-001835-0s7ok4uw	5317	29	actions	action	NNS
cord-001835-0s7ok4uw	5317	30	of	of	IN
cord-001835-0s7ok4uw	5317	31	two	two	CD
cord-001835-0s7ok4uw	5317	32	key	key	JJ
cord-001835-0s7ok4uw	5317	33	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5317	34	families	family	NNS
cord-001835-0s7ok4uw	5317	35	:	:	:
cord-001835-0s7ok4uw	5317	36	Protein	protein	NN
cord-001835-0s7ok4uw	5317	37	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5317	38	kinases	kinase	NNS
cord-001835-0s7ok4uw	5317	39	and	and	CC
cord-001835-0s7ok4uw	5317	40	protein	protein	NN
cord-001835-0s7ok4uw	5317	41	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5317	42	phosphatases	phosphatase	NNS
cord-001835-0s7ok4uw	5317	43	.	.	.
cord-001835-0s7ok4uw	5318	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	5318	2	,	,	,
cord-001835-0s7ok4uw	5318	3	both	both	DT
cord-001835-0s7ok4uw	5318	4	families	family	NNS
cord-001835-0s7ok4uw	5318	5	include	include	VBP
cord-001835-0s7ok4uw	5318	6	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	5318	7	receptor	receptor	NN
cord-001835-0s7ok4uw	5318	8	-	-	HYPH
cord-001835-0s7ok4uw	5318	9	like	like	JJ
cord-001835-0s7ok4uw	5318	10	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5318	11	,	,	,
cord-001835-0s7ok4uw	5318	12	namely	namely	RB
cord-001835-0s7ok4uw	5318	13	the	the	DT
cord-001835-0s7ok4uw	5318	14	receptor	receptor	NN
cord-001835-0s7ok4uw	5318	15	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5318	16	kinases	kinase	NNS
cord-001835-0s7ok4uw	5318	17	(	(	-LRB-
cord-001835-0s7ok4uw	5318	18	RTKs	RTKs	NNP
cord-001835-0s7ok4uw	5318	19	)	)	-RRB-
cord-001835-0s7ok4uw	5318	20	and	and	CC
cord-001835-0s7ok4uw	5318	21	the	the	DT
cord-001835-0s7ok4uw	5318	22	receptor	receptor	NN
cord-001835-0s7ok4uw	5318	23	-	-	HYPH
cord-001835-0s7ok4uw	5318	24	like	like	JJ
cord-001835-0s7ok4uw	5318	25	PTPs	ptp	NNS
cord-001835-0s7ok4uw	5318	26	(	(	-LRB-
cord-001835-0s7ok4uw	5318	27	RPTPs	RPTPs	NNP
cord-001835-0s7ok4uw	5318	28	)	)	-RRB-
cord-001835-0s7ok4uw	5318	29	.	.	.
cord-001835-0s7ok4uw	5319	1	While	while	IN
cord-001835-0s7ok4uw	5319	2	the	the	DT
cord-001835-0s7ok4uw	5319	3	regulation	regulation	NN
cord-001835-0s7ok4uw	5319	4	and	and	CC
cord-001835-0s7ok4uw	5319	5	actions	action	NNS
cord-001835-0s7ok4uw	5319	6	of	of	IN
cord-001835-0s7ok4uw	5319	7	many	many	JJ
cord-001835-0s7ok4uw	5319	8	RTKs	rtk	NNS
cord-001835-0s7ok4uw	5319	9	are	be	VBP
cord-001835-0s7ok4uw	5319	10	well	well	RB
cord-001835-0s7ok4uw	5319	11	characterized	characterize	VBN
cord-001835-0s7ok4uw	5319	12	,	,	,
cord-001835-0s7ok4uw	5319	13	the	the	DT
cord-001835-0s7ok4uw	5319	14	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	5319	15	controlling	control	VBG
cord-001835-0s7ok4uw	5319	16	the	the	DT
cord-001835-0s7ok4uw	5319	17	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5319	18	activity	activity	NN
cord-001835-0s7ok4uw	5319	19	of	of	IN
cord-001835-0s7ok4uw	5319	20	RPTPs	rptp	NNS
cord-001835-0s7ok4uw	5319	21	and	and	CC
cord-001835-0s7ok4uw	5319	22	how	how	WRB
cord-001835-0s7ok4uw	5319	23	they	-PRON-	PRP
cord-001835-0s7ok4uw	5319	24	interact	interact	VBP
cord-001835-0s7ok4uw	5319	25	with	with	IN
cord-001835-0s7ok4uw	5319	26	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5319	27	substrates	substrate	NNS
cord-001835-0s7ok4uw	5319	28	remain	remain	VBP
cord-001835-0s7ok4uw	5319	29	to	to	TO
cord-001835-0s7ok4uw	5319	30	be	be	VB
cord-001835-0s7ok4uw	5319	31	fully	fully	RB
cord-001835-0s7ok4uw	5319	32	explained	explain	VBN
cord-001835-0s7ok4uw	5319	33	.	.	.
cord-001835-0s7ok4uw	5320	1	Thus	thus	RB
cord-001835-0s7ok4uw	5320	2	,	,	,
cord-001835-0s7ok4uw	5320	3	understanding	understand	VBG
cord-001835-0s7ok4uw	5320	4	how	how	WRB
cord-001835-0s7ok4uw	5320	5	these	these	DT
cord-001835-0s7ok4uw	5320	6	receptors	receptor	NNS
cord-001835-0s7ok4uw	5320	7	function	function	VBP
cord-001835-0s7ok4uw	5320	8	and	and	CC
cord-001835-0s7ok4uw	5320	9	interact	interact	VBP
cord-001835-0s7ok4uw	5320	10	will	will	MD
cord-001835-0s7ok4uw	5320	11	give	give	VB
cord-001835-0s7ok4uw	5320	12	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	5320	13	insights	insight	NNS
cord-001835-0s7ok4uw	5320	14	into	into	IN
cord-001835-0s7ok4uw	5320	15	how	how	WRB
cord-001835-0s7ok4uw	5320	16	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5320	17	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	5320	18	is	be	VBZ
cord-001835-0s7ok4uw	5320	19	finely	finely	RB
cord-001835-0s7ok4uw	5320	20	tuned	tune	VBN
cord-001835-0s7ok4uw	5320	21	in	in	IN
cord-001835-0s7ok4uw	5320	22	cells	cell	NNS
cord-001835-0s7ok4uw	5320	23	,	,	,
cord-001835-0s7ok4uw	5320	24	and	and	CC
cord-001835-0s7ok4uw	5320	25	how	how	WRB
cord-001835-0s7ok4uw	5320	26	it	-PRON-	PRP
cord-001835-0s7ok4uw	5320	27	can	can	MD
cord-001835-0s7ok4uw	5320	28	be	be	VB
cord-001835-0s7ok4uw	5320	29	modulated	modulate	VBN
cord-001835-0s7ok4uw	5320	30	.	.	.
cord-001835-0s7ok4uw	5321	1	Increasing	increase	VBG
cord-001835-0s7ok4uw	5321	2	evidence	evidence	NN
cord-001835-0s7ok4uw	5321	3	indicates	indicate	VBZ
cord-001835-0s7ok4uw	5321	4	that	that	IN
cord-001835-0s7ok4uw	5321	5	RPTPs	RPTPs	NNP
cord-001835-0s7ok4uw	5321	6	,	,	,
cord-001835-0s7ok4uw	5321	7	like	like	IN
cord-001835-0s7ok4uw	5321	8	RTKs	RTKs	NNP
cord-001835-0s7ok4uw	5321	9	,	,	,
cord-001835-0s7ok4uw	5321	10	are	be	VBP
cord-001835-0s7ok4uw	5321	11	regulated	regulate	VBN
cord-001835-0s7ok4uw	5321	12	by	by	IN
cord-001835-0s7ok4uw	5321	13	homodimerization	homodimerization	NNP
cord-001835-0s7ok4uw	5321	14	.	.	.
cord-001835-0s7ok4uw	5322	1	However	however	RB
cord-001835-0s7ok4uw	5322	2	,	,	,
cord-001835-0s7ok4uw	5322	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	5322	4	appears	appear	VBZ
cord-001835-0s7ok4uw	5322	5	that	that	IN
cord-001835-0s7ok4uw	5322	6	homodimerization	homodimerization	NN
cord-001835-0s7ok4uw	5322	7	inhibits	inhibit	VBZ
cord-001835-0s7ok4uw	5322	8	the	the	DT
cord-001835-0s7ok4uw	5322	9	activity	activity	NN
cord-001835-0s7ok4uw	5322	10	of	of	IN
cord-001835-0s7ok4uw	5322	11	most	most	JJS
cord-001835-0s7ok4uw	5322	12	RPTPs	rptp	NNS
cord-001835-0s7ok4uw	5322	13	.	.	.
cord-001835-0s7ok4uw	5323	1	Even	even	RB
cord-001835-0s7ok4uw	5323	2	though	though	IN
cord-001835-0s7ok4uw	5323	3	the	the	DT
cord-001835-0s7ok4uw	5323	4	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	5323	5	(	(	-LRB-
cord-001835-0s7ok4uw	5323	6	TM	TM	NNP
cord-001835-0s7ok4uw	5323	7	)	)	-RRB-
cord-001835-0s7ok4uw	5323	8	and	and	CC
cord-001835-0s7ok4uw	5323	9	the	the	DT
cord-001835-0s7ok4uw	5323	10	juxtamembrane	juxtamembrane	NNP
cord-001835-0s7ok4uw	5323	11	domains	domain	NNS
cord-001835-0s7ok4uw	5323	12	have	have	VBP
cord-001835-0s7ok4uw	5323	13	been	be	VBN
cord-001835-0s7ok4uw	5323	14	proposed	propose	VBN
cord-001835-0s7ok4uw	5323	15	to	to	TO
cord-001835-0s7ok4uw	5323	16	be	be	VB
cord-001835-0s7ok4uw	5323	17	involved	involve	VBN
cord-001835-0s7ok4uw	5323	18	in	in	IN
cord-001835-0s7ok4uw	5323	19	this	this	DT
cord-001835-0s7ok4uw	5323	20	process	process	NN
cord-001835-0s7ok4uw	5323	21	,	,	,
cord-001835-0s7ok4uw	5323	22	there	there	EX
cord-001835-0s7ok4uw	5323	23	is	be	VBZ
cord-001835-0s7ok4uw	5323	24	no	no	DT
cord-001835-0s7ok4uw	5323	25	clear	clear	JJ
cord-001835-0s7ok4uw	5323	26	structure	structure	NN
cord-001835-0s7ok4uw	5323	27	-	-	HYPH
cord-001835-0s7ok4uw	5323	28	based	base	VBN
cord-001835-0s7ok4uw	5323	29	proposal	proposal	NN
cord-001835-0s7ok4uw	5323	30	for	for	IN
cord-001835-0s7ok4uw	5323	31	the	the	DT
cord-001835-0s7ok4uw	5323	32	role	role	NN
cord-001835-0s7ok4uw	5323	33	of	of	IN
cord-001835-0s7ok4uw	5323	34	these	these	DT
cord-001835-0s7ok4uw	5323	35	regions	region	NNS
cord-001835-0s7ok4uw	5323	36	.	.	.
cord-001835-0s7ok4uw	5324	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	5324	2	,	,	,
cord-001835-0s7ok4uw	5324	3	several	several	JJ
cord-001835-0s7ok4uw	5324	4	RPTPs	rptp	NNS
cord-001835-0s7ok4uw	5324	5	have	have	VBP
cord-001835-0s7ok4uw	5324	6	been	be	VBN
cord-001835-0s7ok4uw	5324	7	identified	identify	VBN
cord-001835-0s7ok4uw	5324	8	as	as	IN
cord-001835-0s7ok4uw	5324	9	candidate	candidate	NN
cord-001835-0s7ok4uw	5324	10	regulators	regulator	NNS
cord-001835-0s7ok4uw	5324	11	of	of	IN
cord-001835-0s7ok4uw	5324	12	RTKs	rtk	NNS
cord-001835-0s7ok4uw	5324	13	.	.	.
cord-001835-0s7ok4uw	5325	1	In	in	IN
cord-001835-0s7ok4uw	5325	2	particular	particular	JJ
cord-001835-0s7ok4uw	5325	3	,	,	,
cord-001835-0s7ok4uw	5325	4	the	the	DT
cord-001835-0s7ok4uw	5325	5	Receptor	receptor	NN
cord-001835-0s7ok4uw	5325	6	-	-	HYPH
cord-001835-0s7ok4uw	5325	7	type	type	NN
cord-001835-0s7ok4uw	5325	8	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5325	9	-	-	HYPH
cord-001835-0s7ok4uw	5325	10	protein	protein	NN
cord-001835-0s7ok4uw	5325	11	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	5325	12	eta	eta	NNP
cord-001835-0s7ok4uw	5325	13	(	(	-LRB-
cord-001835-0s7ok4uw	5325	14	PTPRJ	PTPRJ	NNP
cord-001835-0s7ok4uw	5325	15	;	;	:
cord-001835-0s7ok4uw	5325	16	also	also	RB
cord-001835-0s7ok4uw	5325	17	known	know	VBN
cord-001835-0s7ok4uw	5325	18	as	as	IN
cord-001835-0s7ok4uw	5325	19	DEP1	DEP1	NNP
cord-001835-0s7ok4uw	5325	20	or	or	CC
cord-001835-0s7ok4uw	5325	21	CD148	CD148	NNP
cord-001835-0s7ok4uw	5325	22	)	)	-RRB-
cord-001835-0s7ok4uw	5325	23	is	be	VBZ
cord-001835-0s7ok4uw	5325	24	capable	capable	JJ
cord-001835-0s7ok4uw	5325	25	of	of	IN
cord-001835-0s7ok4uw	5325	26	attenuating	attenuate	VBG
cord-001835-0s7ok4uw	5325	27	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5325	28	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5325	29	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	5325	30	.	.	.
cord-001835-0s7ok4uw	5326	1	Physical	physical	JJ
cord-001835-0s7ok4uw	5326	2	interactions	interaction	NNS
cord-001835-0s7ok4uw	5326	3	of	of	IN
cord-001835-0s7ok4uw	5326	4	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5326	5	with	with	IN
cord-001835-0s7ok4uw	5326	6	PTPRJ	PTPRJ	NNP
cord-001835-0s7ok4uw	5326	7	at	at	IN
cord-001835-0s7ok4uw	5326	8	the	the	DT
cord-001835-0s7ok4uw	5326	9	cell	cell	NN
cord-001835-0s7ok4uw	5326	10	surface	surface	NN
cord-001835-0s7ok4uw	5326	11	have	have	VBP
cord-001835-0s7ok4uw	5326	12	been	be	VBN
cord-001835-0s7ok4uw	5326	13	documented	document	VBN
cord-001835-0s7ok4uw	5326	14	,	,	,
cord-001835-0s7ok4uw	5326	15	but	but	CC
cord-001835-0s7ok4uw	5326	16	the	the	DT
cord-001835-0s7ok4uw	5326	17	basis	basis	NN
cord-001835-0s7ok4uw	5326	18	for	for	IN
cord-001835-0s7ok4uw	5326	19	these	these	DT
cord-001835-0s7ok4uw	5326	20	interactions	interaction	NNS
cord-001835-0s7ok4uw	5326	21	is	be	VBZ
cord-001835-0s7ok4uw	5326	22	unknown	unknown	JJ
cord-001835-0s7ok4uw	5326	23	.	.	.
cord-001835-0s7ok4uw	5327	1	Here	here	RB
cord-001835-0s7ok4uw	5327	2	,	,	,
cord-001835-0s7ok4uw	5327	3	using	use	VBG
cord-001835-0s7ok4uw	5327	4	a	a	DT
cord-001835-0s7ok4uw	5327	5	dominant	dominant	JJ
cord-001835-0s7ok4uw	5327	6	-	-	HYPH
cord-001835-0s7ok4uw	5327	7	negative	negative	JJ
cord-001835-0s7ok4uw	5327	8	transcriptional	transcriptional	JJ
cord-001835-0s7ok4uw	5327	9	activator	activator	NN
cord-001835-0s7ok4uw	5327	10	-	-	HYPH
cord-001835-0s7ok4uw	5327	11	based	base	VBN
cord-001835-0s7ok4uw	5327	12	assay	assay	NN
cord-001835-0s7ok4uw	5327	13	(	(	-LRB-
cord-001835-0s7ok4uw	5327	14	DN	DN	NNP
cord-001835-0s7ok4uw	5327	15	-	-	HYPH
cord-001835-0s7ok4uw	5327	16	AraTM	AraTM	NNP
cord-001835-0s7ok4uw	5327	17	)	)	-RRB-
cord-001835-0s7ok4uw	5327	18	,	,	,
cord-001835-0s7ok4uw	5327	19	and	and	CC
cord-001835-0s7ok4uw	5327	20	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	5327	21	analysis	analysis	NN
cord-001835-0s7ok4uw	5327	22	,	,	,
cord-001835-0s7ok4uw	5327	23	we	-PRON-	PRP
cord-001835-0s7ok4uw	5327	24	show	show	VBP
cord-001835-0s7ok4uw	5327	25	that	that	DT
cord-001835-0s7ok4uw	5327	26	:	:	:
cord-001835-0s7ok4uw	5327	27	(	(	-LRB-
cord-001835-0s7ok4uw	5327	28	1	1	LS
cord-001835-0s7ok4uw	5327	29	)	)	-RRB-
cord-001835-0s7ok4uw	5327	30	PTPRJ	PTPRJ	NNP
cord-001835-0s7ok4uw	5327	31	has	have	VBZ
cord-001835-0s7ok4uw	5327	32	a	a	DT
cord-001835-0s7ok4uw	5327	33	strong	strong	JJ
cord-001835-0s7ok4uw	5327	34	tendency	tendency	NN
cord-001835-0s7ok4uw	5327	35	to	to	IN
cord-001835-0s7ok4uw	5327	36	homodimerize	homodimerize	NNP
cord-001835-0s7ok4uw	5327	37	,	,	,
cord-001835-0s7ok4uw	5327	38	(	(	-LRB-
cord-001835-0s7ok4uw	5327	39	2	2	LS
cord-001835-0s7ok4uw	5327	40	)	)	-RRB-
cord-001835-0s7ok4uw	5327	41	PTPRJ	PTPRJ	NNP
cord-001835-0s7ok4uw	5327	42	heterodimerizes	heterodimerizes	NNP
cord-001835-0s7ok4uw	5327	43	with	with	IN
cord-001835-0s7ok4uw	5327	44	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5327	45	through	through	IN
cord-001835-0s7ok4uw	5327	46	TM	TM	NNP
cord-001835-0s7ok4uw	5327	47	-	-	HYPH
cord-001835-0s7ok4uw	5327	48	TM	TM	NNP
cord-001835-0s7ok4uw	5327	49	interactions	interaction	NNS
cord-001835-0s7ok4uw	5327	50	,	,	,
cord-001835-0s7ok4uw	5327	51	(	(	-LRB-
cord-001835-0s7ok4uw	5327	52	3	3	LS
cord-001835-0s7ok4uw	5327	53	)	)	-RRB-
cord-001835-0s7ok4uw	5328	1	these	these	DT
cord-001835-0s7ok4uw	5328	2	interactions	interaction	NNS
cord-001835-0s7ok4uw	5328	3	are	be	VBP
cord-001835-0s7ok4uw	5328	4	mediated	mediate	VBN
cord-001835-0s7ok4uw	5328	5	by	by	IN
cord-001835-0s7ok4uw	5328	6	specific	specific	JJ
cord-001835-0s7ok4uw	5328	7	residues	residue	NNS
cord-001835-0s7ok4uw	5328	8	,	,	,
cord-001835-0s7ok4uw	5328	9	and	and	CC
cord-001835-0s7ok4uw	5328	10	can	can	MD
cord-001835-0s7ok4uw	5328	11	be	be	VB
cord-001835-0s7ok4uw	5328	12	modulated	modulate	VBN
cord-001835-0s7ok4uw	5328	13	by	by	IN
cord-001835-0s7ok4uw	5328	14	the	the	DT
cord-001835-0s7ok4uw	5328	15	delivery	delivery	NN
cord-001835-0s7ok4uw	5328	16	of	of	IN
cord-001835-0s7ok4uw	5328	17	peptide	peptide	JJ
cord-001835-0s7ok4uw	5328	18	binders	binder	NNS
cord-001835-0s7ok4uw	5328	19	.	.	.
cord-001835-0s7ok4uw	5329	1	This	this	DT
cord-001835-0s7ok4uw	5329	2	work	work	NN
cord-001835-0s7ok4uw	5329	3	represents	represent	VBZ
cord-001835-0s7ok4uw	5329	4	the	the	DT
cord-001835-0s7ok4uw	5329	5	first	first	JJ
cord-001835-0s7ok4uw	5329	6	structure	structure	NN
cord-001835-0s7ok4uw	5329	7	-	-	HYPH
cord-001835-0s7ok4uw	5329	8	function	function	NN
cord-001835-0s7ok4uw	5329	9	study	study	NN
cord-001835-0s7ok4uw	5329	10	of	of	IN
cord-001835-0s7ok4uw	5329	11	RPTP	RPTP	NNP
cord-001835-0s7ok4uw	5329	12	-	-	HYPH
cord-001835-0s7ok4uw	5329	13	RTK	RTK	NNP
cord-001835-0s7ok4uw	5329	14	interaction	interaction	NN
cord-001835-0s7ok4uw	5329	15	,	,	,
cord-001835-0s7ok4uw	5329	16	and	and	CC
cord-001835-0s7ok4uw	5329	17	may	may	MD
cord-001835-0s7ok4uw	5329	18	not	not	RB
cord-001835-0s7ok4uw	5329	19	only	only	RB
cord-001835-0s7ok4uw	5329	20	result	result	VB
cord-001835-0s7ok4uw	5329	21	in	in	IN
cord-001835-0s7ok4uw	5329	22	significant	significant	JJ
cord-001835-0s7ok4uw	5329	23	progress	progress	NN
cord-001835-0s7ok4uw	5329	24	towards	towards	IN
cord-001835-0s7ok4uw	5329	25	a	a	DT
cord-001835-0s7ok4uw	5329	26	better	well	JJR
cord-001835-0s7ok4uw	5329	27	understanding	understanding	NN
cord-001835-0s7ok4uw	5329	28	of	of	IN
cord-001835-0s7ok4uw	5329	29	the	the	DT
cord-001835-0s7ok4uw	5329	30	basic	basic	JJ
cord-001835-0s7ok4uw	5329	31	biology	biology	NN
cord-001835-0s7ok4uw	5329	32	of	of	IN
cord-001835-0s7ok4uw	5329	33	RPTPs	rptp	NNS
cord-001835-0s7ok4uw	5329	34	in	in	IN
cord-001835-0s7ok4uw	5329	35	cancer	cancer	NN
cord-001835-0s7ok4uw	5329	36	cells	cell	NNS
cord-001835-0s7ok4uw	5329	37	,	,	,
cord-001835-0s7ok4uw	5329	38	but	but	CC
cord-001835-0s7ok4uw	5329	39	also	also	RB
cord-001835-0s7ok4uw	5329	40	offer	offer	VBP
cord-001835-0s7ok4uw	5329	41	new	new	JJ
cord-001835-0s7ok4uw	5329	42	possibilities	possibility	NNS
cord-001835-0s7ok4uw	5329	43	for	for	IN
cord-001835-0s7ok4uw	5329	44	targeting	target	VBG
cord-001835-0s7ok4uw	5329	45	protein	protein	NN
cord-001835-0s7ok4uw	5329	46	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5329	47	phosphatases	phosphatase	NNS
cord-001835-0s7ok4uw	5329	48	for	for	IN
cord-001835-0s7ok4uw	5329	49	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	5329	50	modulation	modulation	NN
cord-001835-0s7ok4uw	5329	51	of	of	IN
cord-001835-0s7ok4uw	5329	52	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5329	53	in	in	IN
cord-001835-0s7ok4uw	5329	54	oncology	oncology	NN
cord-001835-0s7ok4uw	5329	55	.	.	.
cord-001835-0s7ok4uw	5330	1	Inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	5330	2	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5330	3	dimerization	dimerization	NN
cord-001835-0s7ok4uw	5330	4	and	and	CC
cord-001835-0s7ok4uw	5330	5	signaling	signal	VBG
cord-001835-0s7ok4uw	5330	6	through	through	IN
cord-001835-0s7ok4uw	5330	7	targeted	target	VBN
cord-001835-0s7ok4uw	5330	8	delivery	delivery	NN
cord-001835-0s7ok4uw	5330	9	of	of	IN
cord-001835-0s7ok4uw	5330	10	juxtamembrane	juxtamembrane	NNP
cord-001835-0s7ok4uw	5330	11	domain	domain	NN
cord-001835-0s7ok4uw	5330	12	peptide	peptide	NN
cord-001835-0s7ok4uw	5330	13	mimics	mimic	VBZ
cord-001835-0s7ok4uw	5330	14	using	use	VBG
cord-001835-0s7ok4uw	5330	15	pHLIP	pHLIP	NNP
cord-001835-0s7ok4uw	5331	1	Anastasia	Anastasia	NNP
cord-001835-0s7ok4uw	5331	2	Thevenin	Thevenin	NNP
cord-001835-0s7ok4uw	5331	3	1	1	CD
cord-001835-0s7ok4uw	5331	4	,	,	,
cord-001835-0s7ok4uw	5331	5	Kelly	Kelly	NNP
cord-001835-0s7ok4uw	5331	6	Burns	Burns	NNP
cord-001835-0s7ok4uw	5331	7	1	1	CD
cord-001835-0s7ok4uw	5331	8	,	,	,
cord-001835-0s7ok4uw	5331	9	Janessa	Janessa	NNP
cord-001835-0s7ok4uw	5331	10	Guerre	Guerre	NNP
cord-001835-0s7ok4uw	5331	11	-	-	HYPH
cord-001835-0s7ok4uw	5331	12	Chaley	Chaley	NNP
cord-001835-0s7ok4uw	5331	13	1	1	CD
cord-001835-0s7ok4uw	5331	14	,	,	,
cord-001835-0s7ok4uw	5331	15	Damien	Damien	NNP
cord-001835-0s7ok4uw	5331	16	Thevenin	Thevenin	NNP
cord-001835-0s7ok4uw	5331	17	1	1	CD
cord-001835-0s7ok4uw	5331	18	1	1	CD
cord-001835-0s7ok4uw	5331	19	Regulating	Regulating	NNP
cord-001835-0s7ok4uw	5331	20	Receptor	Receptor	NNP
cord-001835-0s7ok4uw	5331	21	Tyrosine	Tyrosine	NNP
cord-001835-0s7ok4uw	5331	22	Kinase	Kinase	NNP
cord-001835-0s7ok4uw	5332	1	Signaling	signal	VBG
cord-001835-0s7ok4uw	5333	1	The	the	DT
cord-001835-0s7ok4uw	5333	2	elevated	elevated	JJ
cord-001835-0s7ok4uw	5333	3	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	5333	4	of	of	IN
cord-001835-0s7ok4uw	5333	5	key	key	JJ
cord-001835-0s7ok4uw	5333	6	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	5333	7	tyrosines	tyrosine	NNS
cord-001835-0s7ok4uw	5333	8	on	on	IN
cord-001835-0s7ok4uw	5333	9	oncogenic	oncogenic	JJ
cord-001835-0s7ok4uw	5333	10	signaling	signal	VBG
cord-001835-0s7ok4uw	5333	11	proteins	protein	NNS
cord-001835-0s7ok4uw	5333	12	that	that	WDT
cord-001835-0s7ok4uw	5333	13	result	result	VBP
cord-001835-0s7ok4uw	5333	14	from	from	IN
cord-001835-0s7ok4uw	5333	15	aberrant	aberrant	JJ
cord-001835-0s7ok4uw	5333	16	protein	protein	NN
cord-001835-0s7ok4uw	5333	17	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5333	18	kinases	kinase	NNS
cord-001835-0s7ok4uw	5333	19	activity	activity	NN
cord-001835-0s7ok4uw	5333	20	plays	play	VBZ
cord-001835-0s7ok4uw	5333	21	well	well	RB
cord-001835-0s7ok4uw	5333	22	-	-	HYPH
cord-001835-0s7ok4uw	5333	23	ABSTRACT	abstract	JJ
cord-001835-0s7ok4uw	5333	24	established	establish	VBD
cord-001835-0s7ok4uw	5333	25	roles	role	NNS
cord-001835-0s7ok4uw	5333	26	in	in	IN
cord-001835-0s7ok4uw	5333	27	promoting	promote	VBG
cord-001835-0s7ok4uw	5333	28	tumorigenesis	tumorigenesis	NN
cord-001835-0s7ok4uw	5333	29	and	and	CC
cord-001835-0s7ok4uw	5333	30	in	in	IN
cord-001835-0s7ok4uw	5333	31	the	the	DT
cord-001835-0s7ok4uw	5333	32	high	high	JJ
cord-001835-0s7ok4uw	5333	33	frequency	frequency	NN
cord-001835-0s7ok4uw	5333	34	with	with	IN
cord-001835-0s7ok4uw	5333	35	which	which	WDT
cord-001835-0s7ok4uw	5333	36	resistance	resistance	NN
cord-001835-0s7ok4uw	5333	37	arises	arise	VBZ
cord-001835-0s7ok4uw	5333	38	to	to	IN
cord-001835-0s7ok4uw	5333	39	existing	exist	VBG
cord-001835-0s7ok4uw	5333	40	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	5333	41	treatment	treatment	NN
cord-001835-0s7ok4uw	5333	42	.	.	.
cord-001835-0s7ok4uw	5334	1	For	for	IN
cord-001835-0s7ok4uw	5334	2	instance	instance	NN
cord-001835-0s7ok4uw	5334	3	,	,	,
cord-001835-0s7ok4uw	5334	4	this	this	DT
cord-001835-0s7ok4uw	5334	5	is	be	VBZ
cord-001835-0s7ok4uw	5334	6	the	the	DT
cord-001835-0s7ok4uw	5334	7	case	case	NN
cord-001835-0s7ok4uw	5334	8	for	for	IN
cord-001835-0s7ok4uw	5334	9	the	the	DT
cord-001835-0s7ok4uw	5334	10	epidermal	epidermal	JJ
cord-001835-0s7ok4uw	5334	11	growth	growth	NN
cord-001835-0s7ok4uw	5334	12	factor	factor	NN
cord-001835-0s7ok4uw	5334	13	receptor	receptor	NN
cord-001835-0s7ok4uw	5334	14	(	(	-LRB-
cord-001835-0s7ok4uw	5334	15	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5334	16	)	)	-RRB-
cord-001835-0s7ok4uw	5334	17	.	.	.
cord-001835-0s7ok4uw	5335	1	Thus	thus	RB
cord-001835-0s7ok4uw	5335	2	,	,	,
cord-001835-0s7ok4uw	5335	3	there	there	EX
cord-001835-0s7ok4uw	5335	4	is	be	VBZ
cord-001835-0s7ok4uw	5335	5	a	a	DT
cord-001835-0s7ok4uw	5335	6	clear	clear	JJ
cord-001835-0s7ok4uw	5335	7	need	need	NN
cord-001835-0s7ok4uw	5335	8	for	for	IN
cord-001835-0s7ok4uw	5335	9	novel	novel	JJ
cord-001835-0s7ok4uw	5335	10	specific	specific	JJ
cord-001835-0s7ok4uw	5335	11	targeting	target	VBG
cord-001835-0s7ok4uw	5335	12	methods	method	NNS
cord-001835-0s7ok4uw	5335	13	to	to	TO
cord-001835-0s7ok4uw	5335	14	inhibit	inhibit	VB
cord-001835-0s7ok4uw	5335	15	the	the	DT
cord-001835-0s7ok4uw	5335	16	activity	activity	NN
cord-001835-0s7ok4uw	5335	17	of	of	IN
cord-001835-0s7ok4uw	5335	18	receptor	receptor	NN
cord-001835-0s7ok4uw	5335	19	protein	protein	NN
cord-001835-0s7ok4uw	5335	20	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5335	21	kinases	kinase	NNS
cord-001835-0s7ok4uw	5335	22	,	,	,
cord-001835-0s7ok4uw	5335	23	such	such	JJ
cord-001835-0s7ok4uw	5335	24	as	as	IN
cord-001835-0s7ok4uw	5335	25	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5335	26	,	,	,
cord-001835-0s7ok4uw	5335	27	in	in	IN
cord-001835-0s7ok4uw	5335	28	cancer	cancer	NN
cord-001835-0s7ok4uw	5335	29	.	.	.
cord-001835-0s7ok4uw	5336	1	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5336	2	becomes	become	VBZ
cord-001835-0s7ok4uw	5336	3	activated	activate	VBN
cord-001835-0s7ok4uw	5336	4	upon	upon	IN
cord-001835-0s7ok4uw	5336	5	ligand	ligand	NN
cord-001835-0s7ok4uw	5336	6	binding	binding	NN
cord-001835-0s7ok4uw	5336	7	to	to	IN
cord-001835-0s7ok4uw	5336	8	the	the	DT
cord-001835-0s7ok4uw	5336	9	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	5336	10	domain	domain	NN
cord-001835-0s7ok4uw	5336	11	,	,	,
cord-001835-0s7ok4uw	5336	12	leading	lead	VBG
cord-001835-0s7ok4uw	5336	13	to	to	IN
cord-001835-0s7ok4uw	5336	14	receptor	receptor	NN
cord-001835-0s7ok4uw	5336	15	dimerization	dimerization	NN
cord-001835-0s7ok4uw	5336	16	.	.	.
cord-001835-0s7ok4uw	5337	1	The	the	DT
cord-001835-0s7ok4uw	5337	2	juxtamembrane	juxtamembrane	NN
cord-001835-0s7ok4uw	5337	3	(	(	-LRB-
cord-001835-0s7ok4uw	5337	4	JM	JM	NNP
cord-001835-0s7ok4uw	5337	5	)	)	-RRB-
cord-001835-0s7ok4uw	5337	6	domain	domain	NN
cord-001835-0s7ok4uw	5337	7	of	of	IN
cord-001835-0s7ok4uw	5337	8	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5337	9	is	be	VBZ
cord-001835-0s7ok4uw	5337	10	critical	critical	JJ
cord-001835-0s7ok4uw	5337	11	for	for	IN
cord-001835-0s7ok4uw	5337	12	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	5337	13	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5337	14	kinase	kinase	NN
cord-001835-0s7ok4uw	5337	15	activity	activity	NN
cord-001835-0s7ok4uw	5337	16	and	and	CC
cord-001835-0s7ok4uw	5337	17	receptor	receptor	NN
cord-001835-0s7ok4uw	5337	18	dimerization	dimerization	NN
cord-001835-0s7ok4uw	5337	19	by	by	IN
cord-001835-0s7ok4uw	5337	20	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	5337	21	the	the	DT
cord-001835-0s7ok4uw	5337	22	active	active	JJ
cord-001835-0s7ok4uw	5337	23	conformation	conformation	NN
cord-001835-0s7ok4uw	5337	24	of	of	IN
cord-001835-0s7ok4uw	5337	25	EGRR	EGRR	NNP
cord-001835-0s7ok4uw	5337	26	through	through	IN
cord-001835-0s7ok4uw	5337	27	the	the	DT
cord-001835-0s7ok4uw	5337	28	formation	formation	NN
cord-001835-0s7ok4uw	5337	29	of	of	IN
cord-001835-0s7ok4uw	5337	30	a	a	DT
cord-001835-0s7ok4uw	5337	31	antiparallel	antiparallel	RB
cord-001835-0s7ok4uw	5337	32	helical	helical	JJ
cord-001835-0s7ok4uw	5337	33	dimer	dimer	NN
cord-001835-0s7ok4uw	5337	34	.	.	.
cord-001835-0s7ok4uw	5338	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	5338	2	,	,	,
cord-001835-0s7ok4uw	5338	3	peptides	peptide	NNS
cord-001835-0s7ok4uw	5338	4	mimicking	mimic	VBG
cord-001835-0s7ok4uw	5338	5	the	the	DT
cord-001835-0s7ok4uw	5338	6	JM	JM	NNP
cord-001835-0s7ok4uw	5338	7	domain	domain	NN
cord-001835-0s7ok4uw	5338	8	-if	-if	NFP
cord-001835-0s7ok4uw	5338	9	specifically	specifically	RB
cord-001835-0s7ok4uw	5338	10	delivered	deliver	VBN
cord-001835-0s7ok4uw	5338	11	to	to	IN
cord-001835-0s7ok4uw	5338	12	cancer	cancer	NN
cord-001835-0s7ok4uw	5338	13	cells	cell	NNS
cord-001835-0s7ok4uw	5338	14	-have	-have	:
cord-001835-0s7ok4uw	5338	15	the	the	DT
cord-001835-0s7ok4uw	5338	16	potential	potential	NN
cord-001835-0s7ok4uw	5338	17	to	to	TO
cord-001835-0s7ok4uw	5338	18	prevent	prevent	VB
cord-001835-0s7ok4uw	5338	19	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5338	20	dimerization	dimerization	NN
cord-001835-0s7ok4uw	5338	21	,	,	,
cord-001835-0s7ok4uw	5338	22	receptor	receptor	NN
cord-001835-0s7ok4uw	5338	23	activation	activation	NN
cord-001835-0s7ok4uw	5338	24	,	,	,
cord-001835-0s7ok4uw	5338	25	downstream	downstream	JJ
cord-001835-0s7ok4uw	5338	26	signaling	signaling	NN
cord-001835-0s7ok4uw	5338	27	,	,	,
cord-001835-0s7ok4uw	5338	28	and	and	CC
cord-001835-0s7ok4uw	5338	29	thus	thus	RB
cord-001835-0s7ok4uw	5338	30	to	to	TO
cord-001835-0s7ok4uw	5338	31	attenuate	attenuate	VB
cord-001835-0s7ok4uw	5338	32	aberrant	aberrant	JJ
cord-001835-0s7ok4uw	5338	33	EGFR	egfr	NN
cord-001835-0s7ok4uw	5338	34	activity	activity	NN
cord-001835-0s7ok4uw	5338	35	in	in	IN
cord-001835-0s7ok4uw	5338	36	cancer	cancer	NN
cord-001835-0s7ok4uw	5338	37	cells	cell	NNS
cord-001835-0s7ok4uw	5338	38	.	.	.
cord-001835-0s7ok4uw	5339	1	Here	here	RB
cord-001835-0s7ok4uw	5339	2	,	,	,
cord-001835-0s7ok4uw	5339	3	pHLIP	phlip	FW
cord-001835-0s7ok4uw	5339	4	(	(	-LRB-
cord-001835-0s7ok4uw	5339	5	pH	pH	NNP
cord-001835-0s7ok4uw	5339	6	Low	Low	NNP
cord-001835-0s7ok4uw	5339	7	Insertion	Insertion	NNP
cord-001835-0s7ok4uw	5339	8	Peptide	Peptide	NNP
cord-001835-0s7ok4uw	5339	9	)	)	-RRB-
cord-001835-0s7ok4uw	5339	10	,	,	,
cord-001835-0s7ok4uw	5339	11	a	a	DT
cord-001835-0s7ok4uw	5339	12	peptide	peptide	NN
cord-001835-0s7ok4uw	5339	13	that	that	WDT
cord-001835-0s7ok4uw	5339	14	can	can	MD
cord-001835-0s7ok4uw	5339	15	selectively	selectively	RB
cord-001835-0s7ok4uw	5339	16	target	target	VB
cord-001835-0s7ok4uw	5339	17	cancer	cancer	NN
cord-001835-0s7ok4uw	5339	18	cells	cell	NNS
cord-001835-0s7ok4uw	5339	19	and	and	CC
cord-001835-0s7ok4uw	5339	20	tumors	tumor	NNS
cord-001835-0s7ok4uw	5339	21	based	base	VBN
cord-001835-0s7ok4uw	5339	22	solely	solely	RB
cord-001835-0s7ok4uw	5339	23	on	on	IN
cord-001835-0s7ok4uw	5339	24	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5339	25	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	5339	26	acidity	acidity	NN
cord-001835-0s7ok4uw	5339	27	,	,	,
cord-001835-0s7ok4uw	5339	28	is	be	VBZ
cord-001835-0s7ok4uw	5339	29	used	use	VBN
cord-001835-0s7ok4uw	5339	30	to	to	TO
cord-001835-0s7ok4uw	5339	31	selectively	selectively	RB
cord-001835-0s7ok4uw	5339	32	translocate	translocate	VB
cord-001835-0s7ok4uw	5339	33	the	the	DT
cord-001835-0s7ok4uw	5339	34	JM	JM	NNP
cord-001835-0s7ok4uw	5339	35	domain	domain	NN
cord-001835-0s7ok4uw	5339	36	of	of	IN
cord-001835-0s7ok4uw	5339	37	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5339	38	in	in	IN
cord-001835-0s7ok4uw	5339	39	cancer	cancer	NN
cord-001835-0s7ok4uw	5339	40	cells	cell	NNS
cord-001835-0s7ok4uw	5339	41	to	to	TO
cord-001835-0s7ok4uw	5339	42	prevent	prevent	VB
cord-001835-0s7ok4uw	5339	43	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5339	44	dimerization	dimerization	NN
cord-001835-0s7ok4uw	5339	45	.	.	.
cord-001835-0s7ok4uw	5340	1	At	at	IN
cord-001835-0s7ok4uw	5340	2	pH	pH	NNP
cord-001835-0s7ok4uw	5340	3	above	above	IN
cord-001835-0s7ok4uw	5340	4	7	7	CD
cord-001835-0s7ok4uw	5340	5	,	,	,
cord-001835-0s7ok4uw	5340	6	pHLIP	pHLIP	NNP
cord-001835-0s7ok4uw	5340	7	is	be	VBZ
cord-001835-0s7ok4uw	5340	8	soluble	soluble	JJ
cord-001835-0s7ok4uw	5340	9	and	and	CC
cord-001835-0s7ok4uw	5340	10	unstructured	unstructured	JJ
cord-001835-0s7ok4uw	5340	11	,	,	,
cord-001835-0s7ok4uw	5340	12	however	however	RB
cord-001835-0s7ok4uw	5340	13	,	,	,
cord-001835-0s7ok4uw	5340	14	when	when	WRB
cord-001835-0s7ok4uw	5340	15	exposed	expose	VBN
cord-001835-0s7ok4uw	5340	16	to	to	IN
cord-001835-0s7ok4uw	5340	17	lower	low	JJR
cord-001835-0s7ok4uw	5340	18	pH	ph	NN
cord-001835-0s7ok4uw	5340	19	such	such	JJ
cord-001835-0s7ok4uw	5340	20	as	as	IN
cord-001835-0s7ok4uw	5340	21	observed	observe	VBN
cord-001835-0s7ok4uw	5340	22	in	in	IN
cord-001835-0s7ok4uw	5340	23	tumors	tumor	NNS
cord-001835-0s7ok4uw	5340	24	,	,	,
cord-001835-0s7ok4uw	5340	25	pHLIP	pHLIP	NNP
cord-001835-0s7ok4uw	5340	26	inserts	insert	VBZ
cord-001835-0s7ok4uw	5340	27	as	as	IN
cord-001835-0s7ok4uw	5340	28	a	a	DT
cord-001835-0s7ok4uw	5340	29	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	5340	30	(	(	-LRB-
cord-001835-0s7ok4uw	5340	31	TM	TM	NNP
cord-001835-0s7ok4uw	5340	32	)	)	-RRB-
cord-001835-0s7ok4uw	5340	33	alphahelix	alphahelix	NNP
cord-001835-0s7ok4uw	5340	34	,	,	,
cord-001835-0s7ok4uw	5340	35	allowing	allow	VBG
cord-001835-0s7ok4uw	5340	36	the	the	DT
cord-001835-0s7ok4uw	5340	37	direct	direct	JJ
cord-001835-0s7ok4uw	5340	38	translocation	translocation	NN
cord-001835-0s7ok4uw	5340	39	of	of	IN
cord-001835-0s7ok4uw	5340	40	cargo	cargo	NN
cord-001835-0s7ok4uw	5340	41	molecules	molecule	NNS
cord-001835-0s7ok4uw	5340	42	into	into	IN
cord-001835-0s7ok4uw	5340	43	the	the	DT
cord-001835-0s7ok4uw	5340	44	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	5340	45	.	.	.
cord-001835-0s7ok4uw	5341	1	Using	use	VBG
cord-001835-0s7ok4uw	5341	2	the	the	DT
cord-001835-0s7ok4uw	5341	3	dominant	dominant	JJ
cord-001835-0s7ok4uw	5341	4	negative	negative	JJ
cord-001835-0s7ok4uw	5341	5	AraC	AraC	NNP
cord-001835-0s7ok4uw	5341	6	-	-	HYPH
cord-001835-0s7ok4uw	5341	7	based	base	VBN
cord-001835-0s7ok4uw	5341	8	transcriptional	transcriptional	NN
cord-001835-0s7ok4uw	5341	9	reported	report	VBD
cord-001835-0s7ok4uw	5341	10	assay	assay	NN
cord-001835-0s7ok4uw	5341	11	(	(	-LRB-
cord-001835-0s7ok4uw	5341	12	DN	DN	NNP
cord-001835-0s7ok4uw	5341	13	-	-	HYPH
cord-001835-0s7ok4uw	5341	14	AraTM	AraTM	NNP
cord-001835-0s7ok4uw	5341	15	)	)	-RRB-
cord-001835-0s7ok4uw	5341	16	,	,	,
cord-001835-0s7ok4uw	5341	17	which	which	WDT
cord-001835-0s7ok4uw	5341	18	assesses	assess	VBZ
cord-001835-0s7ok4uw	5341	19	JM	JM	NNP
cord-001835-0s7ok4uw	5341	20	and	and	CC
cord-001835-0s7ok4uw	5341	21	TM	TM	NNP
cord-001835-0s7ok4uw	5341	22	domain	domain	NN
cord-001835-0s7ok4uw	5341	23	interactions	interaction	NNS
cord-001835-0s7ok4uw	5341	24	in	in	IN
cord-001835-0s7ok4uw	5341	25	cells	cell	NNS
cord-001835-0s7ok4uw	5341	26	membranes	membrane	NNS
cord-001835-0s7ok4uw	5341	27	of	of	IN
cord-001835-0s7ok4uw	5341	28	E.	E.	NNP
cord-001835-0s7ok4uw	5341	29	coli	coli	NNS
cord-001835-0s7ok4uw	5341	30	,	,	,
cord-001835-0s7ok4uw	5341	31	we	-PRON-	PRP
cord-001835-0s7ok4uw	5341	32	show	show	VBP
cord-001835-0s7ok4uw	5341	33	that	that	IN
cord-001835-0s7ok4uw	5341	34	pHLIP	pHLIP	NNP
cord-001835-0s7ok4uw	5341	35	-	-	HYPH
cord-001835-0s7ok4uw	5341	36	JM	JM	NNP
cord-001835-0s7ok4uw	5341	37	is	be	VBZ
cord-001835-0s7ok4uw	5341	38	able	able	JJ
cord-001835-0s7ok4uw	5341	39	to	to	TO
cord-001835-0s7ok4uw	5341	40	disrupt	disrupt	VB
cord-001835-0s7ok4uw	5341	41	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5341	42	dimer	dimer	NN
cord-001835-0s7ok4uw	5341	43	by	by	IN
cord-001835-0s7ok4uw	5341	44	50	50	CD
cord-001835-0s7ok4uw	5341	45	%	%	NN
cord-001835-0s7ok4uw	5341	46	.	.	.
cord-001835-0s7ok4uw	5342	1	Current	current	JJ
cord-001835-0s7ok4uw	5342	2	work	work	NN
cord-001835-0s7ok4uw	5342	3	is	be	VBZ
cord-001835-0s7ok4uw	5342	4	focused	focus	VBN
cord-001835-0s7ok4uw	5342	5	on	on	IN
cord-001835-0s7ok4uw	5342	6	testing	test	VBG
cord-001835-0s7ok4uw	5342	7	the	the	DT
cord-001835-0s7ok4uw	5342	8	ability	ability	NN
cord-001835-0s7ok4uw	5342	9	of	of	IN
cord-001835-0s7ok4uw	5342	10	such	such	JJ
cord-001835-0s7ok4uw	5342	11	pHLIP	pHLIP	NNP
cord-001835-0s7ok4uw	5342	12	-	-	HYPH
cord-001835-0s7ok4uw	5342	13	JM	JM	NNP
cord-001835-0s7ok4uw	5342	14	peptide	peptide	NN
cord-001835-0s7ok4uw	5342	15	conjugate	conjugate	NN
cord-001835-0s7ok4uw	5342	16	to	to	TO
cord-001835-0s7ok4uw	5342	17	perturb	perturb	VB
cord-001835-0s7ok4uw	5342	18	EGFR	EGFR	NNP
cord-001835-0s7ok4uw	5342	19	homodimerization	homodimerization	NN
cord-001835-0s7ok4uw	5342	20	and	and	CC
cord-001835-0s7ok4uw	5342	21	decrease	decrease	VB
cord-001835-0s7ok4uw	5342	22	downstream	downstream	RB
cord-001835-0s7ok4uw	5342	23	signaling	signal	VBG
cord-001835-0s7ok4uw	5342	24	through	through	IN
cord-001835-0s7ok4uw	5342	25	soluble	soluble	JJ
cord-001835-0s7ok4uw	5342	26	kinases	kinase	NNS
cord-001835-0s7ok4uw	5342	27	,	,	,
cord-001835-0s7ok4uw	5342	28	such	such	JJ
cord-001835-0s7ok4uw	5342	29	as	as	IN
cord-001835-0s7ok4uw	5342	30	Akt	Akt	NNP
cord-001835-0s7ok4uw	5342	31	and	and	CC
cord-001835-0s7ok4uw	5342	32	ERK	ERK	NNP
cord-001835-0s7ok4uw	5342	33	,	,	,
cord-001835-0s7ok4uw	5342	34	in	in	IN
cord-001835-0s7ok4uw	5342	35	cancer	cancer	NN
cord-001835-0s7ok4uw	5342	36	cells	cell	NNS
cord-001835-0s7ok4uw	5342	37	.	.	.
cord-001835-0s7ok4uw	5343	1	The	the	DT
cord-001835-0s7ok4uw	5343	2	thumb	thumb	NN
cord-001835-0s7ok4uw	5343	3	subdomain	subdomain	NN
cord-001835-0s7ok4uw	5343	4	of	of	IN
cord-001835-0s7ok4uw	5343	5	yeast	yeast	NN
cord-001835-0s7ok4uw	5343	6	mitochondrial	mitochondrial	NN
cord-001835-0s7ok4uw	5343	7	RNA	RNA	NNP
cord-001835-0s7ok4uw	5343	8	polymerase	polymerase	NN
cord-001835-0s7ok4uw	5343	9	is	be	VBZ
cord-001835-0s7ok4uw	5343	10	involved	involve	VBN
cord-001835-0s7ok4uw	5343	11	in	in	IN
cord-001835-0s7ok4uw	5343	12	processivity	processivity	NN
cord-001835-0s7ok4uw	5343	13	,	,	,
cord-001835-0s7ok4uw	5343	14	transcript	transcript	NN
cord-001835-0s7ok4uw	5343	15	fidelity	fidelity	NN
cord-001835-0s7ok4uw	5343	16	and	and	CC
cord-001835-0s7ok4uw	5343	17	mitochondrial	mitochondrial	NN
cord-001835-0s7ok4uw	5343	18	transcription	transcription	NN
cord-001835-0s7ok4uw	5343	19	factor	factor	NN
cord-001835-0s7ok4uw	5343	20	binding	bind	VBG
cord-001835-0s7ok4uw	5343	21	Gilberto	Gilberto	NNP
cord-001835-0s7ok4uw	5343	22	Velazquez	Velazquez	NNP
cord-001835-0s7ok4uw	5343	23	1	1	CD
cord-001835-0s7ok4uw	5343	24	,	,	,
cord-001835-0s7ok4uw	5343	25	Luis	Luis	NNP
cord-001835-0s7ok4uw	5343	26	Brieba	Brieba	NNP
cord-001835-0s7ok4uw	5343	27	2	2	CD
cord-001835-0s7ok4uw	5343	28	,	,	,
cord-001835-0s7ok4uw	5343	29	Rui	Rui	NNP
cord-001835-0s7ok4uw	5343	30	Sousa	Sousa	NNP
cord-001835-0s7ok4uw	5343	31	3	3	CD
cord-001835-0s7ok4uw	5343	32	1	1	CD
cord-001835-0s7ok4uw	5343	33	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	5343	34	de	de	IN
cord-001835-0s7ok4uw	5343	35	Guadalajara	Guadalajara	NNP
cord-001835-0s7ok4uw	5343	36	,	,	,
cord-001835-0s7ok4uw	5343	37	2	2	CD
cord-001835-0s7ok4uw	5343	38	Langebio	Langebio	NNP
cord-001835-0s7ok4uw	5343	39	Cinvestav	Cinvestav	NNP
cord-001835-0s7ok4uw	5343	40	,	,	,
cord-001835-0s7ok4uw	5343	41	3	3	CD
cord-001835-0s7ok4uw	5343	42	University	University	NNP
cord-001835-0s7ok4uw	5343	43	of	of	IN
cord-001835-0s7ok4uw	5343	44	Texas	Texas	NNP
cord-001835-0s7ok4uw	5343	45	HealthSscience	HealthSscience	NNP
cord-001835-0s7ok4uw	5343	46	Center	Center	NNP
cord-001835-0s7ok4uw	5343	47	at	at	IN
cord-001835-0s7ok4uw	5343	48	San	San	NNP
cord-001835-0s7ok4uw	5343	49	Antonio	Antonio	NNP
cord-001835-0s7ok4uw	5343	50	DNA	DNA	NNP
cord-001835-0s7ok4uw	5343	51	protein	protein	NN
cord-001835-0s7ok4uw	5343	52	interaction	interaction	NN
cord-001835-0s7ok4uw	5344	1	ABSTRACT	ABSTRACT	NNP
cord-001835-0s7ok4uw	5344	2	Single	Single	NNP
cord-001835-0s7ok4uw	5344	3	subunit	subunit	NN
cord-001835-0s7ok4uw	5344	4	RNA	RNA	NNP
cord-001835-0s7ok4uw	5344	5	polymerases	polymerase	NNS
cord-001835-0s7ok4uw	5344	6	have	have	VBP
cord-001835-0s7ok4uw	5344	7	evolved	evolve	VBN
cord-001835-0s7ok4uw	5344	8	two	two	CD
cord-001835-0s7ok4uw	5344	9	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	5344	10	to	to	TO
cord-001835-0s7ok4uw	5344	11	synthesize	synthesize	VB
cord-001835-0s7ok4uw	5344	12	long	long	JJ
cord-001835-0s7ok4uw	5344	13	transcripts	transcript	NNS
cord-001835-0s7ok4uw	5344	14	without	without	IN
cord-001835-0s7ok4uw	5344	15	falling	fall	VBG
cord-001835-0s7ok4uw	5344	16	off	off	RP
cord-001835-0s7ok4uw	5344	17	a	a	DT
cord-001835-0s7ok4uw	5344	18	DNA	dna	NN
cord-001835-0s7ok4uw	5344	19	template	template	NN
cord-001835-0s7ok4uw	5344	20	:	:	:
cord-001835-0s7ok4uw	5344	21	binding	binding	NN
cord-001835-0s7ok4uw	5344	22	of	of	IN
cord-001835-0s7ok4uw	5344	23	nascent	nascent	JJ
cord-001835-0s7ok4uw	5344	24	RNA	RNA	NNP
cord-001835-0s7ok4uw	5344	25	and	and	CC
cord-001835-0s7ok4uw	5344	26	interactions	interaction	NNS
cord-001835-0s7ok4uw	5344	27	with	with	IN
cord-001835-0s7ok4uw	5344	28	an	an	DT
cord-001835-0s7ok4uw	5344	29	RNA	RNA	NNP
cord-001835-0s7ok4uw	5344	30	:	:	:
cord-001835-0s7ok4uw	5344	31	DNA	dna	NN
cord-001835-0s7ok4uw	5344	32	hybrid	hybrid	NN
cord-001835-0s7ok4uw	5344	33	.	.	.
cord-001835-0s7ok4uw	5345	1	Mitochondrial	Mitochondrial	NNP
cord-001835-0s7ok4uw	5345	2	RNA	RNA	NNP
cord-001835-0s7ok4uw	5345	3	polymerases	polymerase	NNS
cord-001835-0s7ok4uw	5345	4	share	share	VBP
cord-001835-0s7ok4uw	5345	5	a	a	DT
cord-001835-0s7ok4uw	5345	6	common	common	JJ
cord-001835-0s7ok4uw	5345	7	ancestor	ancestor	NN
cord-001835-0s7ok4uw	5345	8	with	with	IN
cord-001835-0s7ok4uw	5345	9	T	t	NN
cord-001835-0s7ok4uw	5345	10	-	-	HYPH
cord-001835-0s7ok4uw	5345	11	odd	odd	JJ
cord-001835-0s7ok4uw	5345	12	bacteriophage	bacteriophage	NN
cord-001835-0s7ok4uw	5345	13	single	single	JJ
cord-001835-0s7ok4uw	5345	14	subunit	subunit	NN
cord-001835-0s7ok4uw	5345	15	RNA	RNA	NNP
cord-001835-0s7ok4uw	5345	16	polymerases	polymerase	NNS
cord-001835-0s7ok4uw	5345	17	.	.	.
cord-001835-0s7ok4uw	5346	1	Herein	herein	RB
cord-001835-0s7ok4uw	5346	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	5346	3	characterized	characterize	VBD
cord-001835-0s7ok4uw	5346	4	the	the	DT
cord-001835-0s7ok4uw	5346	5	role	role	NN
cord-001835-0s7ok4uw	5346	6	of	of	IN
cord-001835-0s7ok4uw	5346	7	the	the	DT
cord-001835-0s7ok4uw	5346	8	thumb	thumb	NN
cord-001835-0s7ok4uw	5346	9	subdomain	subdomain	NN
cord-001835-0s7ok4uw	5346	10	of	of	IN
cord-001835-0s7ok4uw	5346	11	the	the	DT
cord-001835-0s7ok4uw	5346	12	yeast	yeast	NN
cord-001835-0s7ok4uw	5346	13	mtRNA	mtrna	NN
cord-001835-0s7ok4uw	5346	14	polymerase	polymerase	NN
cord-001835-0s7ok4uw	5346	15	gene	gene	NN
cord-001835-0s7ok4uw	5346	16	(	(	-LRB-
cord-001835-0s7ok4uw	5346	17	RPO41	RPO41	NNP
cord-001835-0s7ok4uw	5346	18	)	)	-RRB-
cord-001835-0s7ok4uw	5346	19	in	in	IN
cord-001835-0s7ok4uw	5346	20	complex	complex	JJ
cord-001835-0s7ok4uw	5346	21	stability	stability	NN
cord-001835-0s7ok4uw	5346	22	,	,	,
cord-001835-0s7ok4uw	5346	23	processivity	processivity	NN
cord-001835-0s7ok4uw	5346	24	,	,	,
cord-001835-0s7ok4uw	5346	25	and	and	CC
cord-001835-0s7ok4uw	5346	26	fidelity	fidelity	NN
cord-001835-0s7ok4uw	5346	27	.	.	.
cord-001835-0s7ok4uw	5347	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5347	2	found	find	VBD
cord-001835-0s7ok4uw	5347	3	that	that	IN
cord-001835-0s7ok4uw	5347	4	deletion	deletion	NN
cord-001835-0s7ok4uw	5347	5	and	and	CC
cord-001835-0s7ok4uw	5347	6	point	point	NN
cord-001835-0s7ok4uw	5347	7	mutants	mutant	NNS
cord-001835-0s7ok4uw	5347	8	of	of	IN
cord-001835-0s7ok4uw	5347	9	the	the	DT
cord-001835-0s7ok4uw	5347	10	thumb	thumb	NN
cord-001835-0s7ok4uw	5347	11	subdomain	subdomain	NN
cord-001835-0s7ok4uw	5347	12	of	of	IN
cord-001835-0s7ok4uw	5347	13	yeast	yeast	NN
cord-001835-0s7ok4uw	5347	14	mtRNA	mtrna	NN
cord-001835-0s7ok4uw	5347	15	polymerase	polymerase	NN
cord-001835-0s7ok4uw	5347	16	increase	increase	VB
cord-001835-0s7ok4uw	5347	17	the	the	DT
cord-001835-0s7ok4uw	5347	18	synthesis	synthesis	NN
cord-001835-0s7ok4uw	5347	19	of	of	IN
cord-001835-0s7ok4uw	5347	20	abortive	abortive	JJ
cord-001835-0s7ok4uw	5347	21	transcripts	transcript	NNS
cord-001835-0s7ok4uw	5347	22	and	and	CC
cord-001835-0s7ok4uw	5347	23	the	the	DT
cord-001835-0s7ok4uw	5347	24	probability	probability	NN
cord-001835-0s7ok4uw	5347	25	that	that	IN
cord-001835-0s7ok4uw	5347	26	the	the	DT
cord-001835-0s7ok4uw	5347	27	polymerase	polymerase	NN
cord-001835-0s7ok4uw	5347	28	will	will	MD
cord-001835-0s7ok4uw	5347	29	disengage	disengage	VB
cord-001835-0s7ok4uw	5347	30	from	from	IN
cord-001835-0s7ok4uw	5347	31	the	the	DT
cord-001835-0s7ok4uw	5347	32	template	template	NN
cord-001835-0s7ok4uw	5347	33	during	during	IN
cord-001835-0s7ok4uw	5347	34	the	the	DT
cord-001835-0s7ok4uw	5347	35	formation	formation	NN
cord-001835-0s7ok4uw	5347	36	of	of	IN
cord-001835-0s7ok4uw	5347	37	the	the	DT
cord-001835-0s7ok4uw	5347	38	late	late	JJ
cord-001835-0s7ok4uw	5347	39	initial	initial	JJ
cord-001835-0s7ok4uw	5347	40	transcription	transcription	NN
cord-001835-0s7ok4uw	5347	41	and	and	CC
cord-001835-0s7ok4uw	5347	42	elongation	elongation	NN
cord-001835-0s7ok4uw	5347	43	complexes	complex	NNS
cord-001835-0s7ok4uw	5347	44	.	.	.
cord-001835-0s7ok4uw	5348	1	Mutations	mutation	NNS
cord-001835-0s7ok4uw	5348	2	in	in	IN
cord-001835-0s7ok4uw	5348	3	the	the	DT
cord-001835-0s7ok4uw	5348	4	thumb	thumb	NN
cord-001835-0s7ok4uw	5348	5	subdomain	subdomain	NN
cord-001835-0s7ok4uw	5348	6	increase	increase	VB
cord-001835-0s7ok4uw	5348	7	the	the	DT
cord-001835-0s7ok4uw	5348	8	amount	amount	NN
cord-001835-0s7ok4uw	5348	9	of	of	IN
cord-001835-0s7ok4uw	5348	10	slippage	slippage	NN
cord-001835-0s7ok4uw	5348	11	products	product	NNS
cord-001835-0s7ok4uw	5348	12	from	from	IN
cord-001835-0s7ok4uw	5348	13	a	a	DT
cord-001835-0s7ok4uw	5348	14	homopolymeric	homopolymeric	JJ
cord-001835-0s7ok4uw	5348	15	template	template	NN
cord-001835-0s7ok4uw	5348	16	and	and	CC
cord-001835-0s7ok4uw	5348	17	,	,	,
cord-001835-0s7ok4uw	5348	18	unexpectedly	unexpectedly	RB
cord-001835-0s7ok4uw	5348	19	,	,	,
cord-001835-0s7ok4uw	5348	20	thumb	thumb	NN
cord-001835-0s7ok4uw	5348	21	subdomain	subdomain	NN
cord-001835-0s7ok4uw	5348	22	deletions	deletion	NNS
cord-001835-0s7ok4uw	5348	23	decrease	decrease	VBP
cord-001835-0s7ok4uw	5348	24	the	the	DT
cord-001835-0s7ok4uw	5348	25	binding	bind	VBG
cord-001835-0s7ok4uw	5348	26	affinity	affinity	NN
cord-001835-0s7ok4uw	5348	27	for	for	IN
cord-001835-0s7ok4uw	5348	28	mitochondrial	mitochondrial	JJ
cord-001835-0s7ok4uw	5348	29	transcription	transcription	NN
cord-001835-0s7ok4uw	5348	30	factor	factor	NN
cord-001835-0s7ok4uw	5348	31	(	(	-LRB-
cord-001835-0s7ok4uw	5348	32	Mtf1	Mtf1	NNP
cord-001835-0s7ok4uw	5348	33	)	)	-RRB-
cord-001835-0s7ok4uw	5348	34	.	.	.
cord-001835-0s7ok4uw	5349	1	The	the	DT
cord-001835-0s7ok4uw	5349	2	latter	latter	JJ
cord-001835-0s7ok4uw	5349	3	suggests	suggest	VBZ
cord-001835-0s7ok4uw	5349	4	that	that	IN
cord-001835-0s7ok4uw	5349	5	the	the	DT
cord-001835-0s7ok4uw	5349	6	thumb	thumb	NN
cord-001835-0s7ok4uw	5349	7	subdomain	subdomain	NN
cord-001835-0s7ok4uw	5349	8	is	be	VBZ
cord-001835-0s7ok4uw	5349	9	part	part	NN
cord-001835-0s7ok4uw	5349	10	of	of	IN
cord-001835-0s7ok4uw	5349	11	an	an	DT
cord-001835-0s7ok4uw	5349	12	extended	extend	VBN
cord-001835-0s7ok4uw	5349	13	bindingsurface	bindingsurface	NN
cord-001835-0s7ok4uw	5349	14	area	area	NN
cord-001835-0s7ok4uw	5349	15	involved	involve	VBN
cord-001835-0s7ok4uw	5349	16	in	in	IN
cord-001835-0s7ok4uw	5349	17	binding	bind	VBG
cord-001835-0s7ok4uw	5349	18	Mtf1	Mtf1	NNP
cord-001835-0s7ok4uw	5349	19	.	.	.
cord-001835-0s7ok4uw	5350	1	Design	design	NN
cord-001835-0s7ok4uw	5350	2	principles	principle	NNS
cord-001835-0s7ok4uw	5350	3	of	of	IN
cord-001835-0s7ok4uw	5350	4	membrane	membrane	NN
cord-001835-0s7ok4uw	5350	5	protein	protein	NN
cord-001835-0s7ok4uw	5350	6	structures	structure	NNS
cord-001835-0s7ok4uw	5350	7	Vladimir	Vladimir	NNP
cord-001835-0s7ok4uw	5350	8	Yarov	Yarov	NNP
cord-001835-0s7ok4uw	5350	9	-	-	HYPH
cord-001835-0s7ok4uw	5350	10	Yarovoy	Yarovoy	NNP
cord-001835-0s7ok4uw	5350	11	1	1	CD
cord-001835-0s7ok4uw	5350	12	,	,	,
cord-001835-0s7ok4uw	5350	13	Diane	Diane	NNP
cord-001835-0s7ok4uw	5350	14	Nguyen	Nguyen	NNP
cord-001835-0s7ok4uw	5350	15	1	1	CD
cord-001835-0s7ok4uw	5350	16	1	1	CD
cord-001835-0s7ok4uw	5350	17	Membrane	Membrane	NNP
cord-001835-0s7ok4uw	5350	18	Protein	Protein	NNP
cord-001835-0s7ok4uw	5350	19	Structure	Structure	NNP
cord-001835-0s7ok4uw	5350	20	Membrane	Membrane	NNP
cord-001835-0s7ok4uw	5350	21	proteins	protein	NNS
cord-001835-0s7ok4uw	5350	22	play	play	VBP
cord-001835-0s7ok4uw	5350	23	key	key	JJ
cord-001835-0s7ok4uw	5350	24	role	role	NN
cord-001835-0s7ok4uw	5350	25	in	in	IN
cord-001835-0s7ok4uw	5350	26	cellular	cellular	JJ
cord-001835-0s7ok4uw	5350	27	signaling	signaling	NN
cord-001835-0s7ok4uw	5350	28	and	and	CC
cord-001835-0s7ok4uw	5350	29	ion	ion	NN
cord-001835-0s7ok4uw	5350	30	transport	transport	NN
cord-001835-0s7ok4uw	5350	31	.	.	.
cord-001835-0s7ok4uw	5351	1	Statistical	statistical	JJ
cord-001835-0s7ok4uw	5351	2	analysis	analysis	NN
cord-001835-0s7ok4uw	5351	3	of	of	IN
cord-001835-0s7ok4uw	5351	4	expanding	expand	VBG
cord-001835-0s7ok4uw	5351	5	database	database	NN
cord-001835-0s7ok4uw	5351	6	of	of	IN
cord-001835-0s7ok4uw	5351	7	high	high	JJ
cord-001835-0s7ok4uw	5351	8	-	-	HYPH
cord-001835-0s7ok4uw	5351	9	resolution	resolution	NN
cord-001835-0s7ok4uw	5351	10	membrane	membrane	NN
cord-001835-0s7ok4uw	5351	11	protein	protein	NN
cord-001835-0s7ok4uw	5351	12	structures	structure	NNS
cord-001835-0s7ok4uw	5351	13	in	in	IN
cord-001835-0s7ok4uw	5351	14	Protein	Protein	NNP
cord-001835-0s7ok4uw	5351	15	Data	Data	NNP
cord-001835-0s7ok4uw	5351	16	Bank	Bank	NNP
cord-001835-0s7ok4uw	5351	17	(	(	-LRB-
cord-001835-0s7ok4uw	5351	18	PDB	PDB	NNP
cord-001835-0s7ok4uw	5351	19	)	)	-RRB-
cord-001835-0s7ok4uw	5351	20	provides	provide	VBZ
cord-001835-0s7ok4uw	5351	21	useful	useful	JJ
cord-001835-0s7ok4uw	5351	22	information	information	NN
cord-001835-0s7ok4uw	5351	23	about	about	IN
cord-001835-0s7ok4uw	5351	24	membrane	membrane	NN
cord-001835-0s7ok4uw	5351	25	protein	protein	NN
cord-001835-0s7ok4uw	5351	26	structure	structure	NN
cord-001835-0s7ok4uw	5351	27	and	and	CC
cord-001835-0s7ok4uw	5351	28	function	function	NN
cord-001835-0s7ok4uw	5351	29	.	.	.
cord-001835-0s7ok4uw	5352	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5352	2	used	use	VBD
cord-001835-0s7ok4uw	5352	3	RosettaMembrane	RosettaMembrane	NNP
cord-001835-0s7ok4uw	5352	4	software	software	NN
cord-001835-0s7ok4uw	5352	5	(	(	-LRB-
cord-001835-0s7ok4uw	5352	6	Yarov	Yarov	NNP
cord-001835-0s7ok4uw	5352	7	-	-	HYPH
cord-001835-0s7ok4uw	5352	8	Yarovoy	Yarovoy	NNP
cord-001835-0s7ok4uw	5352	9	V	V	NNP
cord-001835-0s7ok4uw	5352	10	et	et	NNP
cord-001835-0s7ok4uw	5352	11	al	al	NNP
cord-001835-0s7ok4uw	5352	12	(	(	-LRB-
cord-001835-0s7ok4uw	5352	13	2006	2006	CD
cord-001835-0s7ok4uw	5352	14	)	)	-RRB-
cord-001835-0s7ok4uw	5352	15	Proteins	protein	NNS
cord-001835-0s7ok4uw	5352	16	)	)	-RRB-
cord-001835-0s7ok4uw	5352	17	to	to	TO
cord-001835-0s7ok4uw	5352	18	analyze	analyze	VB
cord-001835-0s7ok4uw	5352	19	300	300	CD
cord-001835-0s7ok4uw	5352	20	unique	unique	JJ
cord-001835-0s7ok4uw	5352	21	alpha	alpha	NN
cord-001835-0s7ok4uw	5352	22	helical	helical	JJ
cord-001835-0s7ok4uw	5352	23	membrane	membrane	NN
cord-001835-0s7ok4uw	5352	24	protein	protein	NN
cord-001835-0s7ok4uw	5352	25	structures	structure	NNS
cord-001835-0s7ok4uw	5352	26	in	in	IN
cord-001835-0s7ok4uw	5352	27	PDB	PDB	NNP
cord-001835-0s7ok4uw	5352	28	and	and	CC
cord-001835-0s7ok4uw	5352	29	derive	derive	VB
cord-001835-0s7ok4uw	5352	30	knowledge	knowledge	NN
cord-001835-0s7ok4uw	5352	31	based	base	VBN
cord-001835-0s7ok4uw	5352	32	energy	energy	NN
cord-001835-0s7ok4uw	5352	33	function	function	NN
cord-001835-0s7ok4uw	5352	34	for	for	IN
cord-001835-0s7ok4uw	5352	35	membrane	membrane	NN
cord-001835-0s7ok4uw	5352	36	protein	protein	NN
cord-001835-0s7ok4uw	5352	37	structure	structure	NN
cord-001835-0s7ok4uw	5352	38	prediction	prediction	NN
cord-001835-0s7ok4uw	5352	39	,	,	,
cord-001835-0s7ok4uw	5352	40	membrane	membrane	NN
cord-001835-0s7ok4uw	5352	41	protein	protein	NN
cord-001835-0s7ok4uw	5352	42	-	-	HYPH
cord-001835-0s7ok4uw	5352	43	protein	protein	NN
cord-001835-0s7ok4uw	5352	44	docking	docking	NN
cord-001835-0s7ok4uw	5352	45	,	,	,
cord-001835-0s7ok4uw	5352	46	and	and	CC
cord-001835-0s7ok4uw	5352	47	membrane	membrane	NN
cord-001835-0s7ok4uw	5352	48	protein	protein	NN
cord-001835-0s7ok4uw	5352	49	design	design	NN
cord-001835-0s7ok4uw	5352	50	.	.	.
cord-001835-0s7ok4uw	5353	1	The	the	DT
cord-001835-0s7ok4uw	5353	2	RosettaMembrane	RosettaMembrane	NNP
cord-001835-0s7ok4uw	5353	3	residue	residue	NN
cord-001835-0s7ok4uw	5353	4	environment	environment	NN
cord-001835-0s7ok4uw	5353	5	energy	energy	NN
cord-001835-0s7ok4uw	5353	6	term	term	NN
cord-001835-0s7ok4uw	5353	7	is	be	VBZ
cord-001835-0s7ok4uw	5353	8	based	base	VBN
cord-001835-0s7ok4uw	5353	9	on	on	IN
cord-001835-0s7ok4uw	5353	10	amino	amino	JJ
cord-001835-0s7ok4uw	5353	11	acid	acid	JJ
cord-001835-0s7ok4uw	5353	12	propensities	propensity	NNS
cord-001835-0s7ok4uw	5353	13	in	in	IN
cord-001835-0s7ok4uw	5353	14	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5353	15	,	,	,
cord-001835-0s7ok4uw	5353	16	interface	interface	NN
cord-001835-0s7ok4uw	5353	17	,	,	,
cord-001835-0s7ok4uw	5353	18	and	and	CC
cord-001835-0s7ok4uw	5353	19	water	water	NN
cord-001835-0s7ok4uw	5353	20	layers	layer	NNS
cord-001835-0s7ok4uw	5353	21	of	of	IN
cord-001835-0s7ok4uw	5353	22	the	the	DT
cord-001835-0s7ok4uw	5353	23	membrane	membrane	NN
cord-001835-0s7ok4uw	5353	24	and	and	CC
cord-001835-0s7ok4uw	5353	25	depends	depend	VBZ
cord-001835-0s7ok4uw	5353	26	on	on	IN
cord-001835-0s7ok4uw	5353	27	the	the	DT
cord-001835-0s7ok4uw	5353	28	residue	residue	NN
cord-001835-0s7ok4uw	5353	29	burial	burial	NN
cord-001835-0s7ok4uw	5353	30	state	state	NN
cord-001835-0s7ok4uw	5353	31	-from	-from	IN
cord-001835-0s7ok4uw	5353	32	being	be	VBG
cord-001835-0s7ok4uw	5353	33	completely	completely	RB
cord-001835-0s7ok4uw	5353	34	buried	bury	VBN
cord-001835-0s7ok4uw	5353	35	within	within	IN
cord-001835-0s7ok4uw	5353	36	a	a	DT
cord-001835-0s7ok4uw	5353	37	protein	protein	NN
cord-001835-0s7ok4uw	5353	38	environment	environment	NN
cord-001835-0s7ok4uw	5353	39	to	to	IN
cord-001835-0s7ok4uw	5353	40	being	be	VBG
cord-001835-0s7ok4uw	5353	41	completely	completely	RB
cord-001835-0s7ok4uw	5353	42	exposed	expose	VBN
cord-001835-0s7ok4uw	5353	43	either	either	CC
cord-001835-0s7ok4uw	5353	44	to	to	IN
cord-001835-0s7ok4uw	5353	45	the	the	DT
cord-001835-0s7ok4uw	5353	46	lipid	lipid	NN
cord-001835-0s7ok4uw	5353	47	or	or	CC
cord-001835-0s7ok4uw	5353	48	water	water	NN
cord-001835-0s7ok4uw	5353	49	environments	environment	NNS
cord-001835-0s7ok4uw	5353	50	.	.	.
cord-001835-0s7ok4uw	5354	1	Residue	residue	NN
cord-001835-0s7ok4uw	5354	2	buried	bury	VBN
cord-001835-0s7ok4uw	5354	3	state	state	NN
cord-001835-0s7ok4uw	5354	4	is	be	VBZ
cord-001835-0s7ok4uw	5354	5	determined	determine	VBN
cord-001835-0s7ok4uw	5354	6	from	from	IN
cord-001835-0s7ok4uw	5354	7	the	the	DT
cord-001835-0s7ok4uw	5354	8	number	number	NN
cord-001835-0s7ok4uw	5354	9	of	of	IN
cord-001835-0s7ok4uw	5354	10	residue	residue	JJ
cord-001835-0s7ok4uw	5354	11	neighbors	neighbor	NNS
cord-001835-0s7ok4uw	5354	12	within	within	IN
cord-001835-0s7ok4uw	5354	13	6	6	CD
cord-001835-0s7ok4uw	5354	14	and	and	CC
cord-001835-0s7ok4uw	5354	15	10	10	CD
cord-001835-0s7ok4uw	5354	16	Å	å	NN
cord-001835-0s7ok4uw	5354	17	spheres	sphere	NNS
cord-001835-0s7ok4uw	5354	18	.	.	.
cord-001835-0s7ok4uw	5355	1	The	the	DT
cord-001835-0s7ok4uw	5355	2	RosettaMembrane	RosettaMembrane	NNP
cord-001835-0s7ok4uw	5355	3	residue	residue	NN
cord-001835-0s7ok4uw	5355	4	-	-	HYPH
cord-001835-0s7ok4uw	5355	5	residue	residue	NN
cord-001835-0s7ok4uw	5355	6	interaction	interaction	NN
cord-001835-0s7ok4uw	5355	7	term	term	NN
cord-001835-0s7ok4uw	5355	8	is	be	VBZ
cord-001835-0s7ok4uw	5355	9	based	base	VBN
cord-001835-0s7ok4uw	5355	10	on	on	IN
cord-001835-0s7ok4uw	5355	11	the	the	DT
cord-001835-0s7ok4uw	5355	12	propensities	propensity	NNS
cord-001835-0s7ok4uw	5355	13	of	of	IN
cord-001835-0s7ok4uw	5355	14	amino	amino	NN
cord-001835-0s7ok4uw	5355	15	acid	acid	NN
cord-001835-0s7ok4uw	5355	16	pairs	pair	NNS
cord-001835-0s7ok4uw	5355	17	to	to	TO
cord-001835-0s7ok4uw	5355	18	be	be	VB
cord-001835-0s7ok4uw	5355	19	in	in	IN
cord-001835-0s7ok4uw	5355	20	close	close	JJ
cord-001835-0s7ok4uw	5355	21	proximity	proximity	NN
cord-001835-0s7ok4uw	5355	22	to	to	IN
cord-001835-0s7ok4uw	5355	23	each	each	DT
cord-001835-0s7ok4uw	5355	24	other	other	JJ
cord-001835-0s7ok4uw	5355	25	within	within	IN
cord-001835-0s7ok4uw	5355	26	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5355	27	,	,	,
cord-001835-0s7ok4uw	5355	28	interface	interface	NN
cord-001835-0s7ok4uw	5355	29	,	,	,
cord-001835-0s7ok4uw	5355	30	and	and	CC
cord-001835-0s7ok4uw	5355	31	water	water	NN
cord-001835-0s7ok4uw	5355	32	layers	layer	NNS
cord-001835-0s7ok4uw	5355	33	.	.	.
cord-001835-0s7ok4uw	5356	1	Results	result	NNS
cord-001835-0s7ok4uw	5356	2	of	of	IN
cord-001835-0s7ok4uw	5356	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5356	4	statistical	statistical	JJ
cord-001835-0s7ok4uw	5356	5	analysis	analysis	NN
cord-001835-0s7ok4uw	5356	6	reveal	reveal	VBP
cord-001835-0s7ok4uw	5356	7	fine	fine	JJ
cord-001835-0s7ok4uw	5356	8	details	detail	NNS
cord-001835-0s7ok4uw	5356	9	of	of	IN
cord-001835-0s7ok4uw	5356	10	favorable	favorable	JJ
cord-001835-0s7ok4uw	5356	11	and	and	CC
cord-001835-0s7ok4uw	5356	12	unfavorable	unfavorable	JJ
cord-001835-0s7ok4uw	5356	13	environments	environment	NNS
cord-001835-0s7ok4uw	5356	14	for	for	IN
cord-001835-0s7ok4uw	5356	15	all	all	DT
cord-001835-0s7ok4uw	5356	16	amino	amino	NN
cord-001835-0s7ok4uw	5356	17	acids	acid	NNS
cord-001835-0s7ok4uw	5356	18	types	type	NNS
cord-001835-0s7ok4uw	5356	19	in	in	IN
cord-001835-0s7ok4uw	5356	20	all	all	DT
cord-001835-0s7ok4uw	5356	21	membrane	membrane	NN
cord-001835-0s7ok4uw	5356	22	layers	layer	NNS
cord-001835-0s7ok4uw	5356	23	and	and	CC
cord-001835-0s7ok4uw	5356	24	residue	residue	NN
cord-001835-0s7ok4uw	5356	25	burial	burial	NN
cord-001835-0s7ok4uw	5356	26	states	state	NNS
cord-001835-0s7ok4uw	5356	27	.	.	.
cord-001835-0s7ok4uw	5357	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5357	2	find	find	VBP
cord-001835-0s7ok4uw	5357	3	that	that	IN
cord-001835-0s7ok4uw	5357	4	large	large	JJ
cord-001835-0s7ok4uw	5357	5	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5357	6	amino	amino	NN
cord-001835-0s7ok4uw	5357	7	acids	acid	NNS
cord-001835-0s7ok4uw	5357	8	are	be	VBP
cord-001835-0s7ok4uw	5357	9	favorable	favorable	JJ
cord-001835-0s7ok4uw	5357	10	facing	face	VBG
cord-001835-0s7ok4uw	5357	11	the	the	DT
cord-001835-0s7ok4uw	5357	12	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5357	13	core	core	NN
cord-001835-0s7ok4uw	5357	14	of	of	IN
cord-001835-0s7ok4uw	5357	15	the	the	DT
cord-001835-0s7ok4uw	5357	16	lipid	lipid	NN
cord-001835-0s7ok4uw	5357	17	bilayer	bilayer	NN
cord-001835-0s7ok4uw	5357	18	.	.	.
cord-001835-0s7ok4uw	5358	1	Small	small	JJ
cord-001835-0s7ok4uw	5358	2	amino	amino	NN
cord-001835-0s7ok4uw	5358	3	acids	acid	NNS
cord-001835-0s7ok4uw	5358	4	are	be	VBP
cord-001835-0s7ok4uw	5358	5	favorable	favorable	JJ
cord-001835-0s7ok4uw	5358	6	facing	face	VBG
cord-001835-0s7ok4uw	5358	7	the	the	DT
cord-001835-0s7ok4uw	5358	8	protein	protein	NN
cord-001835-0s7ok4uw	5358	9	core	core	NN
cord-001835-0s7ok4uw	5358	10	within	within	IN
cord-001835-0s7ok4uw	5358	11	the	the	DT
cord-001835-0s7ok4uw	5358	12	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5358	13	layer	layer	NN
cord-001835-0s7ok4uw	5358	14	of	of	IN
cord-001835-0s7ok4uw	5358	15	the	the	DT
cord-001835-0s7ok4uw	5358	16	membrane	membrane	NN
cord-001835-0s7ok4uw	5358	17	.	.	.
cord-001835-0s7ok4uw	5359	1	Aromatic	aromatic	JJ
cord-001835-0s7ok4uw	5359	2	or	or	CC
cord-001835-0s7ok4uw	5359	3	positively	positively	RB
cord-001835-0s7ok4uw	5359	4	charged	charge	VBN
cord-001835-0s7ok4uw	5359	5	amino	amino	NN
cord-001835-0s7ok4uw	5359	6	acids	acid	NNS
cord-001835-0s7ok4uw	5359	7	and	and	CC
cord-001835-0s7ok4uw	5359	8	favorable	favorable	JJ
cord-001835-0s7ok4uw	5359	9	facing	face	VBG
cord-001835-0s7ok4uw	5359	10	the	the	DT
cord-001835-0s7ok4uw	5359	11	lipid	lipid	NN
cord-001835-0s7ok4uw	5359	12	head	head	NN
cord-001835-0s7ok4uw	5359	13	groups	group	NNS
cord-001835-0s7ok4uw	5359	14	.	.	.
cord-001835-0s7ok4uw	5360	1	Residue	residue	NN
cord-001835-0s7ok4uw	5360	2	-	-	HYPH
cord-001835-0s7ok4uw	5360	3	residue	residue	NN
cord-001835-0s7ok4uw	5360	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	5360	5	are	be	VBP
cord-001835-0s7ok4uw	5360	6	often	often	RB
cord-001835-0s7ok4uw	5360	7	favored	favor	VBN
cord-001835-0s7ok4uw	5360	8	between	between	IN
cord-001835-0s7ok4uw	5360	9	polar	polar	JJ
cord-001835-0s7ok4uw	5360	10	and	and	CC
cord-001835-0s7ok4uw	5360	11	charged	charge	VBN
cord-001835-0s7ok4uw	5360	12	amino	amino	NN
cord-001835-0s7ok4uw	5360	13	acids	acid	NNS
cord-001835-0s7ok4uw	5360	14	and	and	CC
cord-001835-0s7ok4uw	5360	15	also	also	RB
cord-001835-0s7ok4uw	5360	16	between	between	IN
cord-001835-0s7ok4uw	5360	17	some	some	DT
cord-001835-0s7ok4uw	5360	18	of	of	IN
cord-001835-0s7ok4uw	5360	19	small	small	JJ
cord-001835-0s7ok4uw	5360	20	and	and	CC
cord-001835-0s7ok4uw	5360	21	large	large	JJ
cord-001835-0s7ok4uw	5360	22	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5360	23	amino	amino	NN
cord-001835-0s7ok4uw	5360	24	acids	acid	NNS
cord-001835-0s7ok4uw	5360	25	inside	inside	RB
cord-001835-0s7ok4uw	5360	26	of	of	IN
cord-001835-0s7ok4uw	5360	27	the	the	DT
cord-001835-0s7ok4uw	5360	28	protein	protein	NN
cord-001835-0s7ok4uw	5360	29	core	core	NN
cord-001835-0s7ok4uw	5360	30	within	within	IN
cord-001835-0s7ok4uw	5360	31	the	the	DT
cord-001835-0s7ok4uw	5360	32	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5360	33	layer	layer	NN
cord-001835-0s7ok4uw	5360	34	of	of	IN
cord-001835-0s7ok4uw	5360	35	the	the	DT
cord-001835-0s7ok4uw	5360	36	membrane	membrane	NN
cord-001835-0s7ok4uw	5360	37	.	.	.
cord-001835-0s7ok4uw	5361	1	These	these	DT
cord-001835-0s7ok4uw	5361	2	data	datum	NNS
cord-001835-0s7ok4uw	5361	3	will	will	MD
cord-001835-0s7ok4uw	5361	4	be	be	VB
cord-001835-0s7ok4uw	5361	5	useful	useful	JJ
cord-001835-0s7ok4uw	5361	6	for	for	IN
cord-001835-0s7ok4uw	5361	7	rational	rational	JJ
cord-001835-0s7ok4uw	5361	8	design	design	NN
cord-001835-0s7ok4uw	5361	9	of	of	IN
cord-001835-0s7ok4uw	5361	10	novel	novel	JJ
cord-001835-0s7ok4uw	5361	11	membrane	membrane	NN
cord-001835-0s7ok4uw	5361	12	protein	protein	NN
cord-001835-0s7ok4uw	5361	13	structures	structure	NNS
cord-001835-0s7ok4uw	5361	14	and	and	CC
cord-001835-0s7ok4uw	5361	15	functions	function	NNS
cord-001835-0s7ok4uw	5361	16	.	.	.
cord-001835-0s7ok4uw	5362	1	Coordinated	coordinate	VBN
cord-001835-0s7ok4uw	5362	2	gripping	gripping	NN
cord-001835-0s7ok4uw	5362	3	of	of	IN
cord-001835-0s7ok4uw	5362	4	substrate	substrate	NN
cord-001835-0s7ok4uw	5362	5	by	by	IN
cord-001835-0s7ok4uw	5362	6	subunits	subunit	NNS
cord-001835-0s7ok4uw	5362	7	of	of	IN
cord-001835-0s7ok4uw	5362	8	a	a	DT
cord-001835-0s7ok4uw	5362	9	AAA1	AAA1	NNP
cord-001835-0s7ok4uw	5362	10	proteolytic	proteolytic	JJ
cord-001835-0s7ok4uw	5362	11	machine	machine	NN
cord-001835-0s7ok4uw	5362	12	Ohad	Ohad	NNP
cord-001835-0s7ok4uw	5362	13	Yosefson	Yosefson	NNP
cord-001835-0s7ok4uw	5362	14	1	1	CD
cord-001835-0s7ok4uw	5362	15	,	,	,
cord-001835-0s7ok4uw	5362	16	Andrew	Andrew	NNP
cord-001835-0s7ok4uw	5362	17	Nager	Nager	NNP
cord-001835-0s7ok4uw	5362	18	1	1	CD
cord-001835-0s7ok4uw	5362	19	,	,	,
cord-001835-0s7ok4uw	5362	20	Tania	Tania	NNP
cord-001835-0s7ok4uw	5362	21	Baker	Baker	NNP
cord-001835-0s7ok4uw	5362	22	1	1	CD
cord-001835-0s7ok4uw	5363	1	,	,	,
cord-001835-0s7ok4uw	5363	2	Robert	Robert	NNP
cord-001835-0s7ok4uw	5363	3	Sauer	Sauer	NNP
cord-001835-0s7ok4uw	5363	4	1	1	CD
cord-001835-0s7ok4uw	5363	5	1	1	CD
cord-001835-0s7ok4uw	5363	6	Protein	Protein	NNP
cord-001835-0s7ok4uw	5363	7	quality	quality	NN
cord-001835-0s7ok4uw	5363	8	control	control	NN
cord-001835-0s7ok4uw	5363	9	'	'	''
cord-001835-0s7ok4uw	5363	10	or	or	CC
cord-001835-0s7ok4uw	5363	11	'	'	``
cord-001835-0s7ok4uw	5363	12	Protein	protein	NN
cord-001835-0s7ok4uw	5363	13	degradation	degradation	NN
cord-001835-0s7ok4uw	5363	14	'	'	''
cord-001835-0s7ok4uw	5363	15	Hexameric	Hexameric	NNP
cord-001835-0s7ok4uw	5363	16	AAA1	AAA1	NNP
cord-001835-0s7ok4uw	5363	17	protein	protein	NN
cord-001835-0s7ok4uw	5363	18	-	-	HYPH
cord-001835-0s7ok4uw	5363	19	remodeling	remodel	VBG
cord-001835-0s7ok4uw	5363	20	machines	machine	NNS
cord-001835-0s7ok4uw	5363	21	use	use	VBP
cord-001835-0s7ok4uw	5363	22	conserved	conserved	JJ
cord-001835-0s7ok4uw	5363	23	loops	loop	NNS
cord-001835-0s7ok4uw	5363	24	that	that	WDT
cord-001835-0s7ok4uw	5363	25	line	line	VBP
cord-001835-0s7ok4uw	5363	26	the	the	DT
cord-001835-0s7ok4uw	5363	27	axial	axial	JJ
cord-001835-0s7ok4uw	5363	28	pore	pore	NN
cord-001835-0s7ok4uw	5363	29	to	to	TO
cord-001835-0s7ok4uw	5363	30	apply	apply	VB
cord-001835-0s7ok4uw	5363	31	force	force	NN
cord-001835-0s7ok4uw	5363	32	to	to	IN
cord-001835-0s7ok4uw	5363	33	substrates	substrate	NNS
cord-001835-0s7ok4uw	5363	34	during	during	IN
cord-001835-0s7ok4uw	5363	35	the	the	DT
cord-001835-0s7ok4uw	5363	36	mechanical	mechanical	JJ
cord-001835-0s7ok4uw	5363	37	processes	process	NNS
cord-001835-0s7ok4uw	5363	38	of	of	IN
cord-001835-0s7ok4uw	5363	39	protein	protein	NN
cord-001835-0s7ok4uw	5363	40	unfolding	unfolding	NN
cord-001835-0s7ok4uw	5363	41	and	and	CC
cord-001835-0s7ok4uw	5363	42	translocation	translocation	NN
cord-001835-0s7ok4uw	5363	43	.	.	.
cord-001835-0s7ok4uw	5364	1	An	an	DT
cord-001835-0s7ok4uw	5364	2	open	open	JJ
cord-001835-0s7ok4uw	5364	3	question	question	NN
cord-001835-0s7ok4uw	5364	4	in	in	IN
cord-001835-0s7ok4uw	5364	5	the	the	DT
cord-001835-0s7ok4uw	5364	6	AAA1	AAA1	NNP
cord-001835-0s7ok4uw	5364	7	field	field	NN
cord-001835-0s7ok4uw	5364	8	is	be	VBZ
cord-001835-0s7ok4uw	5364	9	whether	whether	IN
cord-001835-0s7ok4uw	5364	10	pore	pore	NN
cord-001835-0s7ok4uw	5364	11	loops	loop	NNS
cord-001835-0s7ok4uw	5364	12	from	from	IN
cord-001835-0s7ok4uw	5364	13	different	different	JJ
cord-001835-0s7ok4uw	5364	14	subunits	subunit	NNS
cord-001835-0s7ok4uw	5364	15	of	of	IN
cord-001835-0s7ok4uw	5364	16	the	the	DT
cord-001835-0s7ok4uw	5364	17	hexameric	hexameric	NN
cord-001835-0s7ok4uw	5364	18	ring	ring	NN
cord-001835-0s7ok4uw	5364	19	grip	grip	NN
cord-001835-0s7ok4uw	5364	20	the	the	DT
cord-001835-0s7ok4uw	5364	21	substrate	substrate	NN
cord-001835-0s7ok4uw	5364	22	coordinately	coordinately	NN
cord-001835-0s7ok4uw	5364	23	(	(	-LRB-
cord-001835-0s7ok4uw	5364	24	all	all	DT
cord-001835-0s7ok4uw	5364	25	six	six	CD
cord-001835-0s7ok4uw	5364	26	subunits	subunit	NNS
cord-001835-0s7ok4uw	5364	27	involved	involve	VBN
cord-001835-0s7ok4uw	5364	28	)	)	-RRB-
cord-001835-0s7ok4uw	5364	29	,	,	,
cord-001835-0s7ok4uw	5364	30	independently	independently	RB
cord-001835-0s7ok4uw	5364	31	(	(	-LRB-
cord-001835-0s7ok4uw	5364	32	one	one	CD
cord-001835-0s7ok4uw	5364	33	subunit	subunit	NN
cord-001835-0s7ok4uw	5364	34	at	at	IN
cord-001835-0s7ok4uw	5364	35	a	a	DT
cord-001835-0s7ok4uw	5364	36	time	time	NN
cord-001835-0s7ok4uw	5364	37	involved	involve	VBN
cord-001835-0s7ok4uw	5364	38	)	)	-RRB-
cord-001835-0s7ok4uw	5364	39	,	,	,
cord-001835-0s7ok4uw	5364	40	or	or	CC
cord-001835-0s7ok4uw	5364	41	partially	partially	RB
cord-001835-0s7ok4uw	5364	42	coordinated	coordinate	VBN
cord-001835-0s7ok4uw	5364	43	(	(	-LRB-
cord-001835-0s7ok4uw	5364	44	two	two	CD
cord-001835-0s7ok4uw	5364	45	or	or	CC
cord-001835-0s7ok4uw	5364	46	three	three	CD
cord-001835-0s7ok4uw	5364	47	subunits	subunit	NNS
cord-001835-0s7ok4uw	5364	48	at	at	IN
cord-001835-0s7ok4uw	5364	49	a	a	DT
cord-001835-0s7ok4uw	5364	50	time	time	NN
cord-001835-0s7ok4uw	5364	51	)	)	-RRB-
cord-001835-0s7ok4uw	5364	52	.	.	.
cord-001835-0s7ok4uw	5365	1	To	to	TO
cord-001835-0s7ok4uw	5365	2	answer	answer	VB
cord-001835-0s7ok4uw	5365	3	this	this	DT
cord-001835-0s7ok4uw	5365	4	question	question	NN
cord-001835-0s7ok4uw	5365	5	,	,	,
cord-001835-0s7ok4uw	5365	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	5365	7	studied	study	VBD
cord-001835-0s7ok4uw	5365	8	covalently	covalently	RB
cord-001835-0s7ok4uw	5365	9	linked	link	VBN
cord-001835-0s7ok4uw	5365	10	hexamers	hexamer	NNS
cord-001835-0s7ok4uw	5365	11	of	of	IN
cord-001835-0s7ok4uw	5365	12	the	the	DT
cord-001835-0s7ok4uw	5365	13	E.	E.	NNP
cord-001835-0s7ok4uw	5365	14	coli	coli	NNS
cord-001835-0s7ok4uw	5365	15	ClpX	ClpX	NNP
cord-001835-0s7ok4uw	5365	16	unfoldase	unfoldase	NNP
cord-001835-0s7ok4uw	5365	17	bearing	bear	VBG
cord-001835-0s7ok4uw	5365	18	different	different	JJ
cord-001835-0s7ok4uw	5365	19	numbers	number	NNS
cord-001835-0s7ok4uw	5365	20	and	and	CC
cord-001835-0s7ok4uw	5365	21	configurations	configuration	NNS
cord-001835-0s7ok4uw	5365	22	of	of	IN
cord-001835-0s7ok4uw	5365	23	wild	wild	JJ
cord-001835-0s7ok4uw	5365	24	-	-	HYPH
cord-001835-0s7ok4uw	5365	25	type	type	NN
cord-001835-0s7ok4uw	5365	26	and	and	CC
cord-001835-0s7ok4uw	5365	27	mutant	mutant	JJ
cord-001835-0s7ok4uw	5365	28	pore	pore	NN
cord-001835-0s7ok4uw	5365	29	loops	loop	NNS
cord-001835-0s7ok4uw	5365	30	and	and	CC
cord-001835-0s7ok4uw	5365	31	challenged	challenge	VBD
cord-001835-0s7ok4uw	5365	32	these	these	DT
cord-001835-0s7ok4uw	5365	33	variants	variant	NNS
cord-001835-0s7ok4uw	5365	34	with	with	IN
cord-001835-0s7ok4uw	5365	35	protein	protein	NN
cord-001835-0s7ok4uw	5365	36	substrates	substrate	NNS
cord-001835-0s7ok4uw	5365	37	with	with	IN
cord-001835-0s7ok4uw	5365	38	a	a	DT
cord-001835-0s7ok4uw	5365	39	broad	broad	JJ
cord-001835-0s7ok4uw	5365	40	range	range	NN
cord-001835-0s7ok4uw	5365	41	of	of	IN
cord-001835-0s7ok4uw	5365	42	stabilities	stability	NNS
cord-001835-0s7ok4uw	5365	43	.	.	.
cord-001835-0s7ok4uw	5366	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5366	2	find	find	VBP
cord-001835-0s7ok4uw	5366	3	that	that	IN
cord-001835-0s7ok4uw	5366	4	successful	successful	JJ
cord-001835-0s7ok4uw	5366	5	unfolding	unfolding	NN
cord-001835-0s7ok4uw	5366	6	of	of	IN
cord-001835-0s7ok4uw	5366	7	increasingly	increasingly	RB
cord-001835-0s7ok4uw	5366	8	resistant	resistant	JJ
cord-001835-0s7ok4uw	5366	9	substrates	substrate	NNS
cord-001835-0s7ok4uw	5366	10	requires	require	VBZ
cord-001835-0s7ok4uw	5366	11	the	the	DT
cord-001835-0s7ok4uw	5366	12	coordinated	coordinated	JJ
cord-001835-0s7ok4uw	5366	13	action	action	NN
cord-001835-0s7ok4uw	5366	14	of	of	IN
cord-001835-0s7ok4uw	5366	15	a	a	DT
cord-001835-0s7ok4uw	5366	16	greater	great	JJR
cord-001835-0s7ok4uw	5366	17	number	number	NN
cord-001835-0s7ok4uw	5366	18	of	of	IN
cord-001835-0s7ok4uw	5366	19	wild	wild	JJ
cord-001835-0s7ok4uw	5366	20	-	-	HYPH
cord-001835-0s7ok4uw	5366	21	type	type	NN
cord-001835-0s7ok4uw	5366	22	pore	pore	NN
cord-001835-0s7ok4uw	5366	23	loops	loop	NNS
cord-001835-0s7ok4uw	5366	24	.	.	.
cord-001835-0s7ok4uw	5367	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	5367	2	results	result	NNS
cord-001835-0s7ok4uw	5367	3	support	support	VBP
cord-001835-0s7ok4uw	5367	4	a	a	DT
cord-001835-0s7ok4uw	5367	5	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5367	6	in	in	IN
cord-001835-0s7ok4uw	5367	7	which	which	WDT
cord-001835-0s7ok4uw	5367	8	a	a	DT
cord-001835-0s7ok4uw	5367	9	power	power	NN
cord-001835-0s7ok4uw	5367	10	stroke	stroke	NN
cord-001835-0s7ok4uw	5367	11	initiated	initiate	VBN
cord-001835-0s7ok4uw	5367	12	in	in	IN
cord-001835-0s7ok4uw	5367	13	one	one	CD
cord-001835-0s7ok4uw	5367	14	subunit	subunit	NN
cord-001835-0s7ok4uw	5367	15	of	of	IN
cord-001835-0s7ok4uw	5367	16	the	the	DT
cord-001835-0s7ok4uw	5367	17	ClpX	ClpX	NNP
cord-001835-0s7ok4uw	5367	18	hexamer	hexamer	NN
cord-001835-0s7ok4uw	5367	19	results	result	NNS
cord-001835-0s7ok4uw	5367	20	in	in	IN
cord-001835-0s7ok4uw	5367	21	the	the	DT
cord-001835-0s7ok4uw	5367	22	simultaneous	simultaneous	JJ
cord-001835-0s7ok4uw	5367	23	movement	movement	NN
cord-001835-0s7ok4uw	5367	24	of	of	IN
cord-001835-0s7ok4uw	5367	25	all	all	DT
cord-001835-0s7ok4uw	5367	26	six	six	CD
cord-001835-0s7ok4uw	5367	27	pore	pore	NN
cord-001835-0s7ok4uw	5367	28	loops	loop	NNS
cord-001835-0s7ok4uw	5367	29	,	,	,
cord-001835-0s7ok4uw	5367	30	which	which	WDT
cord-001835-0s7ok4uw	5367	31	coordinately	coordinately	RB
cord-001835-0s7ok4uw	5367	32	grip	grip	NN
cord-001835-0s7ok4uw	5367	33	and	and	CC
cord-001835-0s7ok4uw	5367	34	apply	apply	VBP
cord-001835-0s7ok4uw	5367	35	force	force	NN
cord-001835-0s7ok4uw	5367	36	to	to	IN
cord-001835-0s7ok4uw	5367	37	the	the	DT
cord-001835-0s7ok4uw	5367	38	substrate	substrate	NN
cord-001835-0s7ok4uw	5367	39	.	.	.
cord-001835-0s7ok4uw	5368	1	Structure	structure	NN
cord-001835-0s7ok4uw	5368	2	and	and	CC
cord-001835-0s7ok4uw	5368	3	function	function	NN
cord-001835-0s7ok4uw	5368	4	of	of	IN
cord-001835-0s7ok4uw	5368	5	the	the	DT
cord-001835-0s7ok4uw	5368	6	Toc159	Toc159	NNP
cord-001835-0s7ok4uw	5368	7	M	M	NNP
cord-001835-0s7ok4uw	5368	8	-	-	HYPH
cord-001835-0s7ok4uw	5368	9	domain	domain	NN
cord-001835-0s7ok4uw	5368	10	,	,	,
cord-001835-0s7ok4uw	5368	11	and	and	CC
cord-001835-0s7ok4uw	5368	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5368	13	role	role	NN
cord-001835-0s7ok4uw	5368	14	in	in	IN
cord-001835-0s7ok4uw	5368	15	targeting	target	VBG
cord-001835-0s7ok4uw	5368	16	the	the	DT
cord-001835-0s7ok4uw	5368	17	preprotein	preprotein	NNP
cord-001835-0s7ok4uw	5368	18	receptor	receptor	NN
cord-001835-0s7ok4uw	5368	19	to	to	IN
cord-001835-0s7ok4uw	5368	20	the	the	DT
cord-001835-0s7ok4uw	5368	21	chloroplast	chloroplast	JJ
cord-001835-0s7ok4uw	5368	22	outer	outer	JJ
cord-001835-0s7ok4uw	5368	23	envelope	envelope	NN
cord-001835-0s7ok4uw	5368	24	membrane	membrane	NN
cord-001835-0s7ok4uw	5368	25	Matthew	Matthew	NNP
cord-001835-0s7ok4uw	5368	26	Smith	Smith	NNP
cord-001835-0s7ok4uw	5368	27	1	1	CD
cord-001835-0s7ok4uw	5368	28	,	,	,
cord-001835-0s7ok4uw	5368	29	Shiu	Shiu	NNP
cord-001835-0s7ok4uw	5368	30	-	-	HYPH
cord-001835-0s7ok4uw	5368	31	Cheung	Cheung	NNP
cord-001835-0s7ok4uw	5368	32	Lung	Lung	NNP
cord-001835-0s7ok4uw	5368	33	2	2	CD
cord-001835-0s7ok4uw	5368	34	,	,	,
cord-001835-0s7ok4uw	5368	35	Prem	Prem	NNP
cord-001835-0s7ok4uw	5368	36	Nichani	Nichani	NNP
cord-001835-0s7ok4uw	5368	37	1	1	CD
cord-001835-0s7ok4uw	5368	38	,	,	,
cord-001835-0s7ok4uw	5368	39	Nicholas	Nicholas	NNP
cord-001835-0s7ok4uw	5368	40	Grimberg	Grimberg	NNP
cord-001835-0s7ok4uw	5368	41	1	1	CD
cord-001835-0s7ok4uw	5368	42	,	,	,
cord-001835-0s7ok4uw	5368	43	J.	J.	NNP
cord-001835-0s7ok4uw	5368	44	Kyle	Kyle	NNP
cord-001835-0s7ok4uw	5368	45	Weston	Weston	NNP
cord-001835-0s7ok4uw	5368	46	1	1	CD
cord-001835-0s7ok4uw	5368	47	,	,	,
cord-001835-0s7ok4uw	5368	48	Shane	Shane	NNP
cord-001835-0s7ok4uw	5368	49	Szalai	Szalai	NNP
cord-001835-0s7ok4uw	5368	50	1	1	CD
cord-001835-0s7ok4uw	5368	51	,	,	,
cord-001835-0s7ok4uw	5368	52	Simon	Simon	NNP
cord-001835-0s7ok4uw	5368	53	Chuong	Chuong	NNP
cord-001835-0s7ok4uw	5368	54	2	2	CD
cord-001835-0s7ok4uw	5368	55	1	1	CD
cord-001835-0s7ok4uw	5368	56	Deartment	Deartment	NNP
cord-001835-0s7ok4uw	5368	57	of	of	IN
cord-001835-0s7ok4uw	5368	58	Biology	Biology	NNP
cord-001835-0s7ok4uw	5368	59	,	,	,
cord-001835-0s7ok4uw	5368	60	Wilfrid	Wilfrid	NNP
cord-001835-0s7ok4uw	5368	61	Laurier	Laurier	NNP
cord-001835-0s7ok4uw	5368	62	University	University	NNP
cord-001835-0s7ok4uw	5368	63	,	,	,
cord-001835-0s7ok4uw	5368	64	2	2	CD
cord-001835-0s7ok4uw	5368	65	Department	Department	NNP
cord-001835-0s7ok4uw	5368	66	of	of	IN
cord-001835-0s7ok4uw	5368	67	Biology	Biology	NNP
cord-001835-0s7ok4uw	5368	68	,	,	,
cord-001835-0s7ok4uw	5368	69	University	University	NNP
cord-001835-0s7ok4uw	5368	70	of	of	IN
cord-001835-0s7ok4uw	5368	71	Waterloo	Waterloo	NNP
cord-001835-0s7ok4uw	5368	72	Chloroplast	Chloroplast	NNP
cord-001835-0s7ok4uw	5368	73	biogenesis	biogenesis	NN
cord-001835-0s7ok4uw	5368	74	and	and	CC
cord-001835-0s7ok4uw	5368	75	function	function	NN
cord-001835-0s7ok4uw	5368	76	rely	rely	VB
cord-001835-0s7ok4uw	5368	77	on	on	IN
cord-001835-0s7ok4uw	5368	78	the	the	DT
cord-001835-0s7ok4uw	5368	79	import	import	NN
cord-001835-0s7ok4uw	5368	80	of	of	IN
cord-001835-0s7ok4uw	5368	81	thousands	thousand	NNS
cord-001835-0s7ok4uw	5368	82	of	of	IN
cord-001835-0s7ok4uw	5368	83	nucleus	nucleus	RB
cord-001835-0s7ok4uw	5368	84	-	-	HYPH
cord-001835-0s7ok4uw	5368	85	encoded	encode	VBN
cord-001835-0s7ok4uw	5368	86	preproteins	preprotein	NNS
cord-001835-0s7ok4uw	5368	87	from	from	IN
cord-001835-0s7ok4uw	5368	88	the	the	DT
cord-001835-0s7ok4uw	5368	89	cytosol	cytosol	NN
cord-001835-0s7ok4uw	5368	90	.	.	.
cord-001835-0s7ok4uw	5369	1	Preprotein	Preprotein	NNP
cord-001835-0s7ok4uw	5369	2	import	import	NN
cord-001835-0s7ok4uw	5369	3	is	be	VBZ
cord-001835-0s7ok4uw	5369	4	supported	support	VBN
cord-001835-0s7ok4uw	5369	5	by	by	IN
cord-001835-0s7ok4uw	5369	6	the	the	DT
cord-001835-0s7ok4uw	5369	7	Toc	Toc	NNP
cord-001835-0s7ok4uw	5369	8	and	and	CC
cord-001835-0s7ok4uw	5369	9	Tic	Tic	NNP
cord-001835-0s7ok4uw	5369	10	(	(	-LRB-
cord-001835-0s7ok4uw	5369	11	Translocon	Translocon	NNP
cord-001835-0s7ok4uw	5369	12	at	at	IN
cord-001835-0s7ok4uw	5369	13	the	the	DT
cord-001835-0s7ok4uw	5369	14	outer	outer	JJ
cord-001835-0s7ok4uw	5369	15	and	and	CC
cord-001835-0s7ok4uw	5369	16	inner	inner	JJ
cord-001835-0s7ok4uw	5369	17	envelope	envelope	NN
cord-001835-0s7ok4uw	5369	18	membranes	membrane	NNS
cord-001835-0s7ok4uw	5369	19	of	of	IN
cord-001835-0s7ok4uw	5369	20	chloroplasts	chloroplast	NNS
cord-001835-0s7ok4uw	5369	21	)	)	-RRB-
cord-001835-0s7ok4uw	5369	22	complexes	complex	NNS
cord-001835-0s7ok4uw	5369	23	,	,	,
cord-001835-0s7ok4uw	5369	24	which	which	WDT
cord-001835-0s7ok4uw	5369	25	work	work	VBP
cord-001835-0s7ok4uw	5369	26	cooperatively	cooperatively	RB
cord-001835-0s7ok4uw	5369	27	to	to	TO
cord-001835-0s7ok4uw	5369	28	translocate	translocate	VB
cord-001835-0s7ok4uw	5369	29	preproteins	preprotein	NNS
cord-001835-0s7ok4uw	5369	30	across	across	IN
cord-001835-0s7ok4uw	5369	31	the	the	DT
cord-001835-0s7ok4uw	5369	32	double	double	JJ
cord-001835-0s7ok4uw	5369	33	-	-	HYPH
cord-001835-0s7ok4uw	5369	34	membrane	membrane	NN
cord-001835-0s7ok4uw	5369	35	envelope	envelope	NN
cord-001835-0s7ok4uw	5369	36	to	to	IN
cord-001835-0s7ok4uw	5369	37	the	the	DT
cord-001835-0s7ok4uw	5369	38	chloroplast	chloroplast	JJ
cord-001835-0s7ok4uw	5369	39	interior	interior	NN
cord-001835-0s7ok4uw	5369	40	.	.	.
cord-001835-0s7ok4uw	5370	1	Toc159	toc159	JJ
cord-001835-0s7ok4uw	5370	2	is	be	VBZ
cord-001835-0s7ok4uw	5370	3	one	one	CD
cord-001835-0s7ok4uw	5370	4	of	of	IN
cord-001835-0s7ok4uw	5370	5	the	the	DT
cord-001835-0s7ok4uw	5370	6	preprotein	preprotein	NNP
cord-001835-0s7ok4uw	5370	7	receptors	receptor	NNS
cord-001835-0s7ok4uw	5370	8	of	of	IN
cord-001835-0s7ok4uw	5370	9	the	the	DT
cord-001835-0s7ok4uw	5370	10	Toc	Toc	NNP
cord-001835-0s7ok4uw	5370	11	complex	complex	NN
cord-001835-0s7ok4uw	5370	12	,	,	,
cord-001835-0s7ok4uw	5370	13	is	be	VBZ
cord-001835-0s7ok4uw	5370	14	also	also	RB
cord-001835-0s7ok4uw	5370	15	encoded	encode	VBN
cord-001835-0s7ok4uw	5370	16	in	in	IN
cord-001835-0s7ok4uw	5370	17	the	the	DT
cord-001835-0s7ok4uw	5370	18	nucleus	nucleus	NN
cord-001835-0s7ok4uw	5370	19	and	and	CC
cord-001835-0s7ok4uw	5370	20	post	post	JJ
cord-001835-0s7ok4uw	5370	21	-	-	NN
cord-001835-0s7ok4uw	5370	22	translationally	translationally	RB
cord-001835-0s7ok4uw	5370	23	targeted	target	VBN
cord-001835-0s7ok4uw	5370	24	to	to	IN
cord-001835-0s7ok4uw	5370	25	the	the	DT
cord-001835-0s7ok4uw	5370	26	chloroplast	chloroplast	NN
cord-001835-0s7ok4uw	5370	27	,	,	,
cord-001835-0s7ok4uw	5370	28	and	and	CC
cord-001835-0s7ok4uw	5370	29	is	be	VBZ
cord-001835-0s7ok4uw	5370	30	comprised	comprise	VBN
cord-001835-0s7ok4uw	5370	31	of	of	IN
cord-001835-0s7ok4uw	5370	32	3	3	CD
cord-001835-0s7ok4uw	5370	33	distinct	distinct	JJ
cord-001835-0s7ok4uw	5370	34	domains	domain	NNS
cord-001835-0s7ok4uw	5370	35	:	:	:
cord-001835-0s7ok4uw	5370	36	1	1	LS
cord-001835-0s7ok4uw	5370	37	)	)	-RRB-
cord-001835-0s7ok4uw	5370	38	the	the	DT
cord-001835-0s7ok4uw	5370	39	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	5370	40	disordered	disordered	JJ
cord-001835-0s7ok4uw	5370	41	N	n	CD
cord-001835-0s7ok4uw	5370	42	-	-	HYPH
cord-001835-0s7ok4uw	5370	43	terminal	terminal	NN
cord-001835-0s7ok4uw	5370	44	Acidic	Acidic	NNP
cord-001835-0s7ok4uw	5370	45	(	(	-LRB-
cord-001835-0s7ok4uw	5370	46	A-	a-	NN
cord-001835-0s7ok4uw	5370	47	)	)	-RRB-
cord-001835-0s7ok4uw	5370	48	domain	domain	NN
cord-001835-0s7ok4uw	5370	49	;	;	:
cord-001835-0s7ok4uw	5370	50	2	2	LS
cord-001835-0s7ok4uw	5370	51	)	)	-RRB-
cord-001835-0s7ok4uw	5370	52	the	the	DT
cord-001835-0s7ok4uw	5370	53	central	central	JJ
cord-001835-0s7ok4uw	5370	54	GTPase	GTPase	NNP
cord-001835-0s7ok4uw	5370	55	(	(	-LRB-
cord-001835-0s7ok4uw	5370	56	G-	G-	NNP
cord-001835-0s7ok4uw	5370	57	)	)	-RRB-
cord-001835-0s7ok4uw	5370	58	domain	domain	NN
cord-001835-0s7ok4uw	5370	59	;	;	:
cord-001835-0s7ok4uw	5370	60	and	and	CC
cord-001835-0s7ok4uw	5370	61	3	3	LS
cord-001835-0s7ok4uw	5370	62	)	)	-RRB-
cord-001835-0s7ok4uw	5370	63	the	the	DT
cord-001835-0s7ok4uw	5370	64	C	c	NN
cord-001835-0s7ok4uw	5370	65	-	-	HYPH
cord-001835-0s7ok4uw	5370	66	terminal	terminal	NN
cord-001835-0s7ok4uw	5370	67	Membrane	membrane	NN
cord-001835-0s7ok4uw	5370	68	(	(	-LRB-
cord-001835-0s7ok4uw	5370	69	M-	m-	NN
cord-001835-0s7ok4uw	5370	70	)	)	-RRB-
cord-001835-0s7ok4uw	5370	71	domain	domain	NN
cord-001835-0s7ok4uw	5370	72	that	that	WDT
cord-001835-0s7ok4uw	5370	73	anchors	anchor	VBZ
cord-001835-0s7ok4uw	5370	74	the	the	DT
cord-001835-0s7ok4uw	5370	75	protein	protein	NN
cord-001835-0s7ok4uw	5370	76	to	to	IN
cord-001835-0s7ok4uw	5370	77	the	the	DT
cord-001835-0s7ok4uw	5370	78	chloroplast	chloroplast	JJ
cord-001835-0s7ok4uw	5370	79	outer	outer	JJ
cord-001835-0s7ok4uw	5370	80	membrane	membrane	NN
cord-001835-0s7ok4uw	5370	81	(	(	-LRB-
cord-001835-0s7ok4uw	5370	82	COM	com	NN
cord-001835-0s7ok4uw	5370	83	)	)	-RRB-
cord-001835-0s7ok4uw	5370	84	through	through	IN
cord-001835-0s7ok4uw	5370	85	an	an	DT
cord-001835-0s7ok4uw	5370	86	unknown	unknown	JJ
cord-001835-0s7ok4uw	5370	87	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5370	88	.	.	.
cord-001835-0s7ok4uw	5371	1	The	the	DT
cord-001835-0s7ok4uw	5371	2	M	M	NNP
cord-001835-0s7ok4uw	5371	3	-	-	HYPH
cord-001835-0s7ok4uw	5371	4	domain	domain	NN
cord-001835-0s7ok4uw	5371	5	has	have	VBZ
cord-001835-0s7ok4uw	5371	6	no	no	DT
cord-001835-0s7ok4uw	5371	7	known	know	VBN
cord-001835-0s7ok4uw	5371	8	homologues	homologue	NNS
cord-001835-0s7ok4uw	5371	9	and	and	CC
cord-001835-0s7ok4uw	5371	10	does	do	VBZ
cord-001835-0s7ok4uw	5371	11	not	not	RB
cord-001835-0s7ok4uw	5371	12	contain	contain	VB
cord-001835-0s7ok4uw	5371	13	a	a	DT
cord-001835-0s7ok4uw	5371	14	predicted	predict	VBN
cord-001835-0s7ok4uw	5371	15	trans	trans	NN
cord-001835-0s7ok4uw	5371	16	-	-	NN
cord-001835-0s7ok4uw	5371	17	membrane	membrane	NN
cord-001835-0s7ok4uw	5371	18	domain	domain	NN
cord-001835-0s7ok4uw	5371	19	,	,	,
cord-001835-0s7ok4uw	5371	20	but	but	CC
cord-001835-0s7ok4uw	5371	21	does	do	VBZ
cord-001835-0s7ok4uw	5371	22	contain	contain	VB
cord-001835-0s7ok4uw	5371	23	intrinsic	intrinsic	JJ
cord-001835-0s7ok4uw	5371	24	chloroplast	chloroplast	NN
cord-001835-0s7ok4uw	5371	25	targeting	target	VBG
cord-001835-0s7ok4uw	5371	26	information	information	NN
cord-001835-0s7ok4uw	5371	27	at	at	IN
cord-001835-0s7ok4uw	5371	28	the	the	DT
cord-001835-0s7ok4uw	5371	29	extreme	extreme	JJ
cord-001835-0s7ok4uw	5371	30	C	c	NN
cord-001835-0s7ok4uw	5371	31	-	-	HYPH
cord-001835-0s7ok4uw	5371	32	terminus	terminus	NN
cord-001835-0s7ok4uw	5371	33	.	.	.
cord-001835-0s7ok4uw	5372	1	The	the	DT
cord-001835-0s7ok4uw	5372	2	M	M	NNP
cord-001835-0s7ok4uw	5372	3	-	-	HYPH
cord-001835-0s7ok4uw	5372	4	domain	domain	NN
cord-001835-0s7ok4uw	5372	5	also	also	RB
cord-001835-0s7ok4uw	5372	6	contains	contain	VBZ
cord-001835-0s7ok4uw	5372	7	a	a	DT
cord-001835-0s7ok4uw	5372	8	predicted	predict	VBN
cord-001835-0s7ok4uw	5372	9	b	b	NN
cord-001835-0s7ok4uw	5372	10	-	-	HYPH
cord-001835-0s7ok4uw	5372	11	helix	helix	NN
cord-001835-0s7ok4uw	5372	12	motif	motif	NN
cord-001835-0s7ok4uw	5372	13	,	,	,
cord-001835-0s7ok4uw	5372	14	which	which	WDT
cord-001835-0s7ok4uw	5372	15	may	may	MD
cord-001835-0s7ok4uw	5372	16	be	be	VB
cord-001835-0s7ok4uw	5372	17	important	important	JJ
cord-001835-0s7ok4uw	5372	18	for	for	IN
cord-001835-0s7ok4uw	5372	19	anchoring	anchor	VBG
cord-001835-0s7ok4uw	5372	20	the	the	DT
cord-001835-0s7ok4uw	5372	21	protein	protein	NN
cord-001835-0s7ok4uw	5372	22	to	to	IN
cord-001835-0s7ok4uw	5372	23	the	the	DT
cord-001835-0s7ok4uw	5372	24	COM	com	NN
cord-001835-0s7ok4uw	5372	25	.	.	.
cord-001835-0s7ok4uw	5373	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5373	2	are	be	VBP
cord-001835-0s7ok4uw	5373	3	interested	interested	JJ
cord-001835-0s7ok4uw	5373	4	in	in	IN
cord-001835-0s7ok4uw	5373	5	characterizing	characterize	VBG
cord-001835-0s7ok4uw	5373	6	the	the	DT
cord-001835-0s7ok4uw	5373	7	structure	structure	NN
cord-001835-0s7ok4uw	5373	8	of	of	IN
cord-001835-0s7ok4uw	5373	9	the	the	DT
cord-001835-0s7ok4uw	5373	10	M	M	NNP
cord-001835-0s7ok4uw	5373	11	-	-	HYPH
cord-001835-0s7ok4uw	5373	12	domain	domain	NN
cord-001835-0s7ok4uw	5373	13	and	and	CC
cord-001835-0s7ok4uw	5373	14	determining	determine	VBG
cord-001835-0s7ok4uw	5373	15	the	the	DT
cord-001835-0s7ok4uw	5373	16	nature	nature	NN
cord-001835-0s7ok4uw	5373	17	of	of	IN
cord-001835-0s7ok4uw	5373	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5373	19	association	association	NN
cord-001835-0s7ok4uw	5373	20	with	with	IN
cord-001835-0s7ok4uw	5373	21	the	the	DT
cord-001835-0s7ok4uw	5373	22	COM	com	NN
cord-001835-0s7ok4uw	5373	23	,	,	,
cord-001835-0s7ok4uw	5373	24	as	as	IN
cord-001835-0s7ok4uw	5373	25	part	part	NN
cord-001835-0s7ok4uw	5373	26	of	of	IN
cord-001835-0s7ok4uw	5373	27	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5373	28	larger	large	JJR
cord-001835-0s7ok4uw	5373	29	goal	goal	NN
cord-001835-0s7ok4uw	5373	30	of	of	IN
cord-001835-0s7ok4uw	5373	31	understanding	understand	VBG
cord-001835-0s7ok4uw	5373	32	the	the	DT
cord-001835-0s7ok4uw	5373	33	role	role	NN
cord-001835-0s7ok4uw	5373	34	Toc159	Toc159	,
cord-001835-0s7ok4uw	5373	35	plays	play	NNS
cord-001835-0s7ok4uw	5373	36	in	in	IN
cord-001835-0s7ok4uw	5373	37	protein	protein	NN
cord-001835-0s7ok4uw	5373	38	import	import	NN
cord-001835-0s7ok4uw	5373	39	into	into	IN
cord-001835-0s7ok4uw	5373	40	chloroplasts	chloroplast	NNS
cord-001835-0s7ok4uw	5373	41	.	.	.
cord-001835-0s7ok4uw	5374	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5374	2	are	be	VBP
cord-001835-0s7ok4uw	5374	3	also	also	RB
cord-001835-0s7ok4uw	5374	4	interested	interested	JJ
cord-001835-0s7ok4uw	5374	5	in	in	IN
cord-001835-0s7ok4uw	5374	6	defining	define	VBG
cord-001835-0s7ok4uw	5374	7	the	the	DT
cord-001835-0s7ok4uw	5374	8	precise	precise	JJ
cord-001835-0s7ok4uw	5374	9	nature	nature	NN
cord-001835-0s7ok4uw	5374	10	of	of	IN
cord-001835-0s7ok4uw	5374	11	the	the	DT
cord-001835-0s7ok4uw	5374	12	targeting	target	VBG
cord-001835-0s7ok4uw	5374	13	information	information	NN
cord-001835-0s7ok4uw	5374	14	contained	contain	VBN
cord-001835-0s7ok4uw	5374	15	within	within	IN
cord-001835-0s7ok4uw	5374	16	the	the	DT
cord-001835-0s7ok4uw	5374	17	extreme	extreme	JJ
cord-001835-0s7ok4uw	5374	18	C	c	NN
cord-001835-0s7ok4uw	5374	19	-	-	HYPH
cord-001835-0s7ok4uw	5374	20	terminus	terminus	NN
cord-001835-0s7ok4uw	5374	21	of	of	IN
cord-001835-0s7ok4uw	5374	22	Toc159	toc159	CD
cord-001835-0s7ok4uw	5374	23	,	,	,
cord-001835-0s7ok4uw	5374	24	elucidating	elucidate	VBG
cord-001835-0s7ok4uw	5374	25	the	the	DT
cord-001835-0s7ok4uw	5374	26	targeting	target	VBG
cord-001835-0s7ok4uw	5374	27	pathway	pathway	NN
cord-001835-0s7ok4uw	5374	28	that	that	WDT
cord-001835-0s7ok4uw	5374	29	is	be	VBZ
cord-001835-0s7ok4uw	5374	30	used	use	VBN
cord-001835-0s7ok4uw	5374	31	,	,	,
cord-001835-0s7ok4uw	5374	32	and	and	CC
cord-001835-0s7ok4uw	5374	33	whether	whether	IN
cord-001835-0s7ok4uw	5374	34	other	other	JJ
cord-001835-0s7ok4uw	5374	35	COM	com	NN
cord-001835-0s7ok4uw	5374	36	proteins	protein	NNS
cord-001835-0s7ok4uw	5374	37	use	use	VBP
cord-001835-0s7ok4uw	5374	38	this	this	DT
cord-001835-0s7ok4uw	5374	39	pathway	pathway	NN
cord-001835-0s7ok4uw	5374	40	.	.	.
cord-001835-0s7ok4uw	5375	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5375	2	will	will	MD
cord-001835-0s7ok4uw	5375	3	present	present	VB
cord-001835-0s7ok4uw	5375	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5375	5	most	most	RBS
cord-001835-0s7ok4uw	5375	6	recent	recent	JJ
cord-001835-0s7ok4uw	5375	7	data	datum	NNS
cord-001835-0s7ok4uw	5375	8	on	on	IN
cord-001835-0s7ok4uw	5375	9	the	the	DT
cord-001835-0s7ok4uw	5375	10	structure	structure	NN
cord-001835-0s7ok4uw	5375	11	,	,	,
cord-001835-0s7ok4uw	5375	12	function	function	NN
cord-001835-0s7ok4uw	5375	13	and	and	CC
cord-001835-0s7ok4uw	5375	14	targeting	targeting	NN
cord-001835-0s7ok4uw	5375	15	of	of	IN
cord-001835-0s7ok4uw	5375	16	the	the	DT
cord-001835-0s7ok4uw	5375	17	Toc159	Toc159	NNP
cord-001835-0s7ok4uw	5375	18	M	M	NNP
cord-001835-0s7ok4uw	5375	19	-	-	HYPH
cord-001835-0s7ok4uw	5375	20	domain	domain	NN
cord-001835-0s7ok4uw	5375	21	.	.	.
cord-001835-0s7ok4uw	5376	1	Structural	structural	JJ
cord-001835-0s7ok4uw	5376	2	investigation	investigation	NN
cord-001835-0s7ok4uw	5376	3	of	of	IN
cord-001835-0s7ok4uw	5376	4	NlpC	NlpC	NNP
cord-001835-0s7ok4uw	5376	5	/	/	SYM
cord-001835-0s7ok4uw	5376	6	P60	P60	NNP
cord-001835-0s7ok4uw	5376	7	protein	protein	NN
cord-001835-0s7ok4uw	5376	8	acquired	acquire	VBN
cord-001835-0s7ok4uw	5376	9	by	by	IN
cord-001835-0s7ok4uw	5376	10	Trichomonas	Trichomonas	NNP
cord-001835-0s7ok4uw	5376	11	vaginalis	vaginali	VBZ
cord-001835-0s7ok4uw	5376	12	through	through	IN
cord-001835-0s7ok4uw	5376	13	a	a	DT
cord-001835-0s7ok4uw	5376	14	lateral	lateral	JJ
cord-001835-0s7ok4uw	5376	15	gene	gene	NN
cord-001835-0s7ok4uw	5376	16	transfer	transfer	NN
cord-001835-0s7ok4uw	5376	17	event	event	NN
cord-001835-0s7ok4uw	5376	18	Jully	Jully	NNP
cord-001835-0s7ok4uw	5376	19	Pinheiro	Pinheiro	NNP
cord-001835-0s7ok4uw	5376	20	1,2	1,2	CD
cord-001835-0s7ok4uw	5376	21	,	,	,
cord-001835-0s7ok4uw	5376	22	Augusto	Augusto	NNP
cord-001835-0s7ok4uw	5376	23	Simoes	Simoes	NNP
cord-001835-0s7ok4uw	5376	24	-	-	HYPH
cord-001835-0s7ok4uw	5376	25	Barbosa	Barbosa	NNP
cord-001835-0s7ok4uw	5376	26	1	1	CD
cord-001835-0s7ok4uw	5377	1	,	,	,
cord-001835-0s7ok4uw	5377	2	David	David	NNP
cord-001835-0s7ok4uw	5377	3	Goldstone	Goldstone	NNP
cord-001835-0s7ok4uw	5377	4	2	2	CD
cord-001835-0s7ok4uw	5377	5	1	1	CD
cord-001835-0s7ok4uw	5377	6	Microbiology	Microbiology	NNP
cord-001835-0s7ok4uw	5377	7	,	,	,
cord-001835-0s7ok4uw	5377	8	School	School	NNP
cord-001835-0s7ok4uw	5377	9	of	of	IN
cord-001835-0s7ok4uw	5377	10	Biological	Biological	NNP
cord-001835-0s7ok4uw	5377	11	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	5377	12	,	,	,
cord-001835-0s7ok4uw	5377	13	University	University	NNP
cord-001835-0s7ok4uw	5377	14	of	of	IN
cord-001835-0s7ok4uw	5377	15	Auckland	Auckland	NNP
cord-001835-0s7ok4uw	5377	16	,	,	,
cord-001835-0s7ok4uw	5377	17	2	2	CD
cord-001835-0s7ok4uw	5377	18	Structural	Structural	NNP
cord-001835-0s7ok4uw	5377	19	Biology	Biology	NNP
cord-001835-0s7ok4uw	5377	20	,	,	,
cord-001835-0s7ok4uw	5377	21	School	School	NNP
cord-001835-0s7ok4uw	5377	22	of	of	IN
cord-001835-0s7ok4uw	5377	23	Biological	Biological	NNP
cord-001835-0s7ok4uw	5377	24	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	5377	25	,	,	,
cord-001835-0s7ok4uw	5377	26	University	University	NNP
cord-001835-0s7ok4uw	5377	27	of	of	IN
cord-001835-0s7ok4uw	5377	28	Auckland	Auckland	NNP
cord-001835-0s7ok4uw	5377	29	Trichomonas	Trichomonas	NNP
cord-001835-0s7ok4uw	5377	30	vaginalis	vaginalis	NN
cord-001835-0s7ok4uw	5377	31	is	be	VBZ
cord-001835-0s7ok4uw	5377	32	an	an	DT
cord-001835-0s7ok4uw	5377	33	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	5377	34	flagellated	flagellated	JJ
cord-001835-0s7ok4uw	5377	35	protozoan	protozoan	NN
cord-001835-0s7ok4uw	5377	36	parasite	parasite	NN
cord-001835-0s7ok4uw	5377	37	that	that	WDT
cord-001835-0s7ok4uw	5377	38	causes	cause	VBZ
cord-001835-0s7ok4uw	5377	39	the	the	DT
cord-001835-0s7ok4uw	5377	40	most	most	RBS
cord-001835-0s7ok4uw	5377	41	common	common	JJ
cord-001835-0s7ok4uw	5377	42	non	non	JJ
cord-001835-0s7ok4uw	5377	43	-	-	JJ
cord-001835-0s7ok4uw	5377	44	viral	viral	JJ
cord-001835-0s7ok4uw	5377	45	sexually	sexually	RB
cord-001835-0s7ok4uw	5377	46	transmitted	transmit	VBN
cord-001835-0s7ok4uw	5377	47	disease	disease	NN
cord-001835-0s7ok4uw	5377	48	,	,	,
cord-001835-0s7ok4uw	5377	49	with	with	IN
cord-001835-0s7ok4uw	5377	50	approximately	approximately	RB
cord-001835-0s7ok4uw	5377	51	200	200	CD
cord-001835-0s7ok4uw	5377	52	million	million	CD
cord-001835-0s7ok4uw	5377	53	cases	case	NNS
cord-001835-0s7ok4uw	5377	54	worldwide	worldwide	RB
cord-001835-0s7ok4uw	5377	55	annually	annually	RB
cord-001835-0s7ok4uw	5377	56	.	.	.
cord-001835-0s7ok4uw	5378	1	Nevertheless	nevertheless	RB
cord-001835-0s7ok4uw	5378	2	,	,	,
cord-001835-0s7ok4uw	5378	3	the	the	DT
cord-001835-0s7ok4uw	5378	4	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5378	5	processes	process	NNS
cord-001835-0s7ok4uw	5378	6	behind	behind	IN
cord-001835-0s7ok4uw	5378	7	T.	t.	NN
cord-001835-0s7ok4uw	5378	8	vaginalis	vaginalis	NN
cord-001835-0s7ok4uw	5378	9	infection	infection	NN
cord-001835-0s7ok4uw	5378	10	and	and	CC
cord-001835-0s7ok4uw	5378	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5378	12	interaction	interaction	NN
cord-001835-0s7ok4uw	5378	13	with	with	IN
cord-001835-0s7ok4uw	5378	14	the	the	DT
cord-001835-0s7ok4uw	5378	15	vaginal	vaginal	JJ
cord-001835-0s7ok4uw	5378	16	microbiota	microbiota	NN
cord-001835-0s7ok4uw	5378	17	are	be	VBP
cord-001835-0s7ok4uw	5378	18	still	still	RB
cord-001835-0s7ok4uw	5378	19	not	not	RB
cord-001835-0s7ok4uw	5378	20	well	well	RB
cord-001835-0s7ok4uw	5378	21	defined	define	VBN
cord-001835-0s7ok4uw	5378	22	.	.	.
cord-001835-0s7ok4uw	5379	1	In	in	IN
cord-001835-0s7ok4uw	5379	2	2007	2007	CD
cord-001835-0s7ok4uw	5379	3	the	the	DT
cord-001835-0s7ok4uw	5379	4	draft	draft	NN
cord-001835-0s7ok4uw	5379	5	genome	genome	NN
cord-001835-0s7ok4uw	5379	6	sequence	sequence	NN
cord-001835-0s7ok4uw	5379	7	of	of	IN
cord-001835-0s7ok4uw	5379	8	Trichomonas	Trichomonas	NNP
cord-001835-0s7ok4uw	5379	9	vaginalis	vaginalis	NN
cord-001835-0s7ok4uw	5379	10	strain	strain	NN
cord-001835-0s7ok4uw	5379	11	G3	G3	NNP
cord-001835-0s7ok4uw	5379	12	was	be	VBD
cord-001835-0s7ok4uw	5379	13	described	describe	VBN
cord-001835-0s7ok4uw	5379	14	,	,	,
cord-001835-0s7ok4uw	5379	15	identifying	identify	VBG
cord-001835-0s7ok4uw	5379	16	60,000	60,000	CD
cord-001835-0s7ok4uw	5379	17	protein	protein	NN
cord-001835-0s7ok4uw	5379	18	-	-	HYPH
cord-001835-0s7ok4uw	5379	19	coding	code	VBG
cord-001835-0s7ok4uw	5379	20	genes	gene	NNS
cord-001835-0s7ok4uw	5379	21	.	.	.
cord-001835-0s7ok4uw	5380	1	Of	of	IN
cord-001835-0s7ok4uw	5380	2	these	these	DT
cord-001835-0s7ok4uw	5380	3	,	,	,
cord-001835-0s7ok4uw	5380	4	nine	nine	CD
cord-001835-0s7ok4uw	5380	5	genes	gene	NNS
cord-001835-0s7ok4uw	5380	6	encode	encode	VBP
cord-001835-0s7ok4uw	5380	7	NlpC	NlpC	NNP
cord-001835-0s7ok4uw	5380	8	/	/	SYM
cord-001835-0s7ok4uw	5380	9	P60-like	P60-like	NNP
cord-001835-0s7ok4uw	5380	10	members	member	NNS
cord-001835-0s7ok4uw	5380	11	.	.	.
cord-001835-0s7ok4uw	5381	1	This	this	DT
cord-001835-0s7ok4uw	5381	2	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5381	3	is	be	VBZ
cord-001835-0s7ok4uw	5381	4	widely	widely	RB
cord-001835-0s7ok4uw	5381	5	represented	represent	VBN
cord-001835-0s7ok4uw	5381	6	in	in	IN
cord-001835-0s7ok4uw	5381	7	the	the	DT
cord-001835-0s7ok4uw	5381	8	different	different	JJ
cord-001835-0s7ok4uw	5381	9	kingdoms	kingdom	NNS
cord-001835-0s7ok4uw	5381	10	of	of	IN
cord-001835-0s7ok4uw	5381	11	life	life	NN
cord-001835-0s7ok4uw	5381	12	and	and	CC
cord-001835-0s7ok4uw	5381	13	has	have	VBZ
cord-001835-0s7ok4uw	5381	14	diverse	diverse	JJ
cord-001835-0s7ok4uw	5381	15	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5381	16	functions	function	NNS
cord-001835-0s7ok4uw	5381	17	,	,	,
cord-001835-0s7ok4uw	5381	18	such	such	JJ
cord-001835-0s7ok4uw	5381	19	as	as	IN
cord-001835-0s7ok4uw	5381	20	amidases	amidases	NNP
cord-001835-0s7ok4uw	5381	21	,	,	,
cord-001835-0s7ok4uw	5381	22	endopeptidases	endopeptidase	NNS
cord-001835-0s7ok4uw	5381	23	and	and	CC
cord-001835-0s7ok4uw	5381	24	acetyltransferases	acetyltransferase	NNS
cord-001835-0s7ok4uw	5381	25	.	.	.
cord-001835-0s7ok4uw	5382	1	Previous	previous	JJ
cord-001835-0s7ok4uw	5382	2	studies	study	NNS
cord-001835-0s7ok4uw	5382	3	have	have	VBP
cord-001835-0s7ok4uw	5382	4	shown	show	VBN
cord-001835-0s7ok4uw	5382	5	that	that	IN
cord-001835-0s7ok4uw	5382	6	members	member	NNS
cord-001835-0s7ok4uw	5382	7	of	of	IN
cord-001835-0s7ok4uw	5382	8	this	this	DT
cord-001835-0s7ok4uw	5382	9	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5382	10	hydrolyze	hydrolyze	VBP
cord-001835-0s7ok4uw	5382	11	specific	specific	JJ
cord-001835-0s7ok4uw	5382	12	peptide	peptide	JJ
cord-001835-0s7ok4uw	5382	13	linkages	linkage	NNS
cord-001835-0s7ok4uw	5382	14	in	in	IN
cord-001835-0s7ok4uw	5382	15	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5382	16	cell	cell	NN
cord-001835-0s7ok4uw	5382	17	walls	wall	NNS
cord-001835-0s7ok4uw	5382	18	affecting	affect	VBG
cord-001835-0s7ok4uw	5382	19	germination	germination	NN
cord-001835-0s7ok4uw	5382	20	,	,	,
cord-001835-0s7ok4uw	5382	21	vegetative	vegetative	JJ
cord-001835-0s7ok4uw	5382	22	growth	growth	NN
cord-001835-0s7ok4uw	5382	23	,	,	,
cord-001835-0s7ok4uw	5382	24	sporulation	sporulation	NN
cord-001835-0s7ok4uw	5382	25	and	and	CC
cord-001835-0s7ok4uw	5382	26	division	division	NN
cord-001835-0s7ok4uw	5382	27	or	or	CC
cord-001835-0s7ok4uw	5382	28	cell	cell	NN
cord-001835-0s7ok4uw	5382	29	lysis	lysis	NN
cord-001835-0s7ok4uw	5382	30	/	/	SYM
cord-001835-0s7ok4uw	5382	31	invasion	invasion	NN
cord-001835-0s7ok4uw	5382	32	.	.	.
cord-001835-0s7ok4uw	5383	1	As	as	IN
cord-001835-0s7ok4uw	5383	2	a	a	DT
cord-001835-0s7ok4uw	5383	3	typical	typical	JJ
cord-001835-0s7ok4uw	5383	4	eukaryote	eukaryote	NN
cord-001835-0s7ok4uw	5383	5	,	,	,
cord-001835-0s7ok4uw	5383	6	the	the	DT
cord-001835-0s7ok4uw	5383	7	protozoan	protozoan	NN
cord-001835-0s7ok4uw	5383	8	parasite	parasite	NN
cord-001835-0s7ok4uw	5383	9	T.	t.	NN
cord-001835-0s7ok4uw	5383	10	vaginalis	vaginalis	NN
cord-001835-0s7ok4uw	5383	11	does	do	VBZ
cord-001835-0s7ok4uw	5383	12	not	not	RB
cord-001835-0s7ok4uw	5383	13	have	have	VB
cord-001835-0s7ok4uw	5383	14	a	a	DT
cord-001835-0s7ok4uw	5383	15	cell	cell	NN
cord-001835-0s7ok4uw	5383	16	wall	wall	NN
cord-001835-0s7ok4uw	5383	17	itself	-PRON-	PRP
cord-001835-0s7ok4uw	5383	18	.	.	.
cord-001835-0s7ok4uw	5384	1	Previous	previous	JJ
cord-001835-0s7ok4uw	5384	2	studies	study	NNS
cord-001835-0s7ok4uw	5384	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	5384	4	that	that	IN
cord-001835-0s7ok4uw	5384	5	the	the	DT
cord-001835-0s7ok4uw	5384	6	T.	T.	NNP
cord-001835-0s7ok4uw	5384	7	vaginalis	vaginalis	NN
cord-001835-0s7ok4uw	5384	8	NlpC	NlpC	NNP
cord-001835-0s7ok4uw	5384	9	/	/	SYM
cord-001835-0s7ok4uw	5384	10	P60	p60	JJ
cord-001835-0s7ok4uw	5384	11	genes	gene	NNS
cord-001835-0s7ok4uw	5384	12	were	be	VBD
cord-001835-0s7ok4uw	5384	13	acquired	acquire	VBN
cord-001835-0s7ok4uw	5384	14	via	via	IN
cord-001835-0s7ok4uw	5384	15	lateral	lateral	JJ
cord-001835-0s7ok4uw	5384	16	gene	gene	NN
cord-001835-0s7ok4uw	5384	17	transfer	transfer	NN
cord-001835-0s7ok4uw	5384	18	from	from	IN
cord-001835-0s7ok4uw	5384	19	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	5384	20	and	and	CC
cord-001835-0s7ok4uw	5384	21	must	must	MD
cord-001835-0s7ok4uw	5384	22	have	have	VB
cord-001835-0s7ok4uw	5384	23	an	an	DT
cord-001835-0s7ok4uw	5384	24	important	important	JJ
cord-001835-0s7ok4uw	5384	25	function	function	NN
cord-001835-0s7ok4uw	5384	26	,	,	,
cord-001835-0s7ok4uw	5384	27	possibly	possibly	RB
cord-001835-0s7ok4uw	5384	28	controlling	control	VBG
cord-001835-0s7ok4uw	5384	29	the	the	DT
cord-001835-0s7ok4uw	5384	30	vaginal	vaginal	JJ
cord-001835-0s7ok4uw	5384	31	microbiota	microbiota	NN
cord-001835-0s7ok4uw	5384	32	and	and	CC
cord-001835-0s7ok4uw	5384	33	aiding	aid	VBG
cord-001835-0s7ok4uw	5384	34	parasite	parasite	JJ
cord-001835-0s7ok4uw	5384	35	invasion	invasion	NN
cord-001835-0s7ok4uw	5384	36	and	and	CC
cord-001835-0s7ok4uw	5384	37	infection	infection	NN
cord-001835-0s7ok4uw	5384	38	.	.	.
cord-001835-0s7ok4uw	5385	1	To	to	TO
cord-001835-0s7ok4uw	5385	2	investigate	investigate	VB
cord-001835-0s7ok4uw	5385	3	the	the	DT
cord-001835-0s7ok4uw	5385	4	function	function	NN
cord-001835-0s7ok4uw	5385	5	of	of	IN
cord-001835-0s7ok4uw	5385	6	the	the	DT
cord-001835-0s7ok4uw	5385	7	NlpC	NlpC	NNP
cord-001835-0s7ok4uw	5385	8	/	/	SYM
cord-001835-0s7ok4uw	5385	9	P60	P60	NNP
cord-001835-0s7ok4uw	5385	10	family	family	NN
cord-001835-0s7ok4uw	5385	11	of	of	IN
cord-001835-0s7ok4uw	5385	12	proteins	protein	NNS
cord-001835-0s7ok4uw	5385	13	in	in	IN
cord-001835-0s7ok4uw	5385	14	T.	t.	NN
cord-001835-0s7ok4uw	5385	15	vaginalis	vaginalis	NN
cord-001835-0s7ok4uw	5385	16	we	-PRON-	PRP
cord-001835-0s7ok4uw	5385	17	have	have	VBP
cord-001835-0s7ok4uw	5385	18	expressed	express	VBN
cord-001835-0s7ok4uw	5385	19	,	,	,
cord-001835-0s7ok4uw	5385	20	purified	purify	VBN
cord-001835-0s7ok4uw	5385	21	and	and	CC
cord-001835-0s7ok4uw	5385	22	crystallized	crystallize	VBD
cord-001835-0s7ok4uw	5385	23	a	a	DT
cord-001835-0s7ok4uw	5385	24	member	member	NN
cord-001835-0s7ok4uw	5385	25	TVAG_119910	TVAG_119910	NNP
cord-001835-0s7ok4uw	5385	26	and	and	CC
cord-001835-0s7ok4uw	5385	27	report	report	VB
cord-001835-0s7ok4uw	5385	28	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5385	29	three	three	CD
cord-001835-0s7ok4uw	5385	30	-	-	HYPH
cord-001835-0s7ok4uw	5385	31	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	5385	32	structure	structure	NN
cord-001835-0s7ok4uw	5385	33	,	,	,
cord-001835-0s7ok4uw	5385	34	determined	determine	VBN
cord-001835-0s7ok4uw	5385	35	at	at	IN
cord-001835-0s7ok4uw	5385	36	1.5	1.5	CD
cord-001835-0s7ok4uw	5385	37	Å	å	NN
cord-001835-0s7ok4uw	5385	38	resolution	resolution	NN
cord-001835-0s7ok4uw	5385	39	,	,	,
cord-001835-0s7ok4uw	5385	40	by	by	IN
cord-001835-0s7ok4uw	5385	41	X	x	NN
cord-001835-0s7ok4uw	5385	42	-	-	NN
cord-001835-0s7ok4uw	5385	43	ray	ray	NN
cord-001835-0s7ok4uw	5385	44	diffraction	diffraction	NN
cord-001835-0s7ok4uw	5385	45	.	.	.
cord-001835-0s7ok4uw	5386	1	The	the	DT
cord-001835-0s7ok4uw	5386	2	structure	structure	NN
cord-001835-0s7ok4uw	5386	3	of	of	IN
cord-001835-0s7ok4uw	5386	4	the	the	DT
cord-001835-0s7ok4uw	5386	5	protein	protein	NN
cord-001835-0s7ok4uw	5386	6	reveals	reveal	VBZ
cord-001835-0s7ok4uw	5386	7	a	a	DT
cord-001835-0s7ok4uw	5386	8	typical	typical	JJ
cord-001835-0s7ok4uw	5386	9	papain	papain	NN
cord-001835-0s7ok4uw	5386	10	-	-	HYPH
cord-001835-0s7ok4uw	5386	11	like	like	IN
cord-001835-0s7ok4uw	5386	12	fold	fold	VB
cord-001835-0s7ok4uw	5386	13	resembling	resemble	VBG
cord-001835-0s7ok4uw	5386	14	peptidoglycan	peptidoglycan	NN
cord-001835-0s7ok4uw	5386	15	hydrolases	hydrolase	NNS
cord-001835-0s7ok4uw	5386	16	from	from	IN
cord-001835-0s7ok4uw	5386	17	the	the	DT
cord-001835-0s7ok4uw	5386	18	NlpC	NlpC	NNP
cord-001835-0s7ok4uw	5386	19	/	/	SYM
cord-001835-0s7ok4uw	5386	20	P60	P60	NNP
cord-001835-0s7ok4uw	5386	21	family	family	NN
cord-001835-0s7ok4uw	5386	22	with	with	IN
cord-001835-0s7ok4uw	5386	23	a	a	DT
cord-001835-0s7ok4uw	5386	24	conserved	conserve	VBN
cord-001835-0s7ok4uw	5386	25	cysteine	cysteine	NN
cord-001835-0s7ok4uw	5386	26	and	and	CC
cord-001835-0s7ok4uw	5386	27	histidine	histidine	NN
cord-001835-0s7ok4uw	5386	28	;	;	:
cord-001835-0s7ok4uw	5386	29	forming	form	VBG
cord-001835-0s7ok4uw	5386	30	the	the	DT
cord-001835-0s7ok4uw	5386	31	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5386	32	residues	residue	NNS
cord-001835-0s7ok4uw	5386	33	.	.	.
cord-001835-0s7ok4uw	5387	1	The	the	DT
cord-001835-0s7ok4uw	5387	2	protein	protein	NN
cord-001835-0s7ok4uw	5387	3	contains	contain	VBZ
cord-001835-0s7ok4uw	5387	4	two	two	CD
cord-001835-0s7ok4uw	5387	5	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5387	6	SH3	SH3	NNP
cord-001835-0s7ok4uw	5387	7	domains	domain	NNS
cord-001835-0s7ok4uw	5387	8	at	at	IN
cord-001835-0s7ok4uw	5387	9	the	the	DT
cord-001835-0s7ok4uw	5387	10	N	n	CD
cord-001835-0s7ok4uw	5387	11	-	-	HYPH
cord-001835-0s7ok4uw	5387	12	terminus	terminus	NN
cord-001835-0s7ok4uw	5387	13	.	.	.
cord-001835-0s7ok4uw	5388	1	This	this	DT
cord-001835-0s7ok4uw	5388	2	domain	domain	NN
cord-001835-0s7ok4uw	5388	3	acts	act	VBZ
cord-001835-0s7ok4uw	5388	4	as	as	IN
cord-001835-0s7ok4uw	5388	5	a	a	DT
cord-001835-0s7ok4uw	5388	6	general	general	JJ
cord-001835-0s7ok4uw	5388	7	binding	binding	NN
cord-001835-0s7ok4uw	5388	8	domain	domain	NN
cord-001835-0s7ok4uw	5388	9	and	and	CC
cord-001835-0s7ok4uw	5388	10	is	be	VBZ
cord-001835-0s7ok4uw	5388	11	likely	likely	JJ
cord-001835-0s7ok4uw	5388	12	to	to	TO
cord-001835-0s7ok4uw	5388	13	aid	aid	VB
cord-001835-0s7ok4uw	5388	14	the	the	DT
cord-001835-0s7ok4uw	5388	15	interaction	interaction	NN
cord-001835-0s7ok4uw	5388	16	of	of	IN
cord-001835-0s7ok4uw	5388	17	the	the	DT
cord-001835-0s7ok4uw	5388	18	NlpC	NlpC	NNP
cord-001835-0s7ok4uw	5388	19	/	/	SYM
cord-001835-0s7ok4uw	5388	20	P60	P60	NNP
cord-001835-0s7ok4uw	5388	21	domain	domain	NN
cord-001835-0s7ok4uw	5388	22	with	with	IN
cord-001835-0s7ok4uw	5388	23	substrate	substrate	JJ
cord-001835-0s7ok4uw	5388	24	components	component	NNS
cord-001835-0s7ok4uw	5388	25	.	.	.
cord-001835-0s7ok4uw	5389	1	Combined	combine	VBN
cord-001835-0s7ok4uw	5389	2	with	with	IN
cord-001835-0s7ok4uw	5389	3	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5389	4	and	and	CC
cord-001835-0s7ok4uw	5389	5	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5389	6	characterization	characterization	NN
cord-001835-0s7ok4uw	5389	7	,	,	,
cord-001835-0s7ok4uw	5389	8	the	the	DT
cord-001835-0s7ok4uw	5389	9	structure	structure	NN
cord-001835-0s7ok4uw	5389	10	of	of	IN
cord-001835-0s7ok4uw	5389	11	this	this	DT
cord-001835-0s7ok4uw	5389	12	NlpC	NlpC	NNP
cord-001835-0s7ok4uw	5389	13	/	/	SYM
cord-001835-0s7ok4uw	5389	14	P60	P60	NNP
cord-001835-0s7ok4uw	5389	15	protein	protein	NN
cord-001835-0s7ok4uw	5389	16	will	will	MD
cord-001835-0s7ok4uw	5389	17	help	help	VB
cord-001835-0s7ok4uw	5389	18	to	to	TO
cord-001835-0s7ok4uw	5389	19	elucidate	elucidate	VB
cord-001835-0s7ok4uw	5389	20	the	the	DT
cord-001835-0s7ok4uw	5389	21	molecular	molecular	JJ
cord-001835-0s7ok4uw	5389	22	origin	origin	NN
cord-001835-0s7ok4uw	5389	23	of	of	IN
cord-001835-0s7ok4uw	5389	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5389	25	hydrolase	hydrolase	NN
cord-001835-0s7ok4uw	5389	26	activity	activity	NN
cord-001835-0s7ok4uw	5389	27	and	and	CC
cord-001835-0s7ok4uw	5389	28	to	to	TO
cord-001835-0s7ok4uw	5389	29	decipher	decipher	VB
cord-001835-0s7ok4uw	5389	30	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5389	31	putative	putative	JJ
cord-001835-0s7ok4uw	5389	32	role	role	NN
cord-001835-0s7ok4uw	5389	33	in	in	IN
cord-001835-0s7ok4uw	5389	34	the	the	DT
cord-001835-0s7ok4uw	5389	35	parasite	parasite	NN
cord-001835-0s7ok4uw	5389	36	infection	infection	NN
cord-001835-0s7ok4uw	5389	37	.	.	.
cord-001835-0s7ok4uw	5390	1	Novel	novel	NN
cord-001835-0s7ok4uw	5390	2	DNA	dna	NN
cord-001835-0s7ok4uw	5390	3	polymerases	polymerase	NNS
cord-001835-0s7ok4uw	5390	4	from	from	IN
cord-001835-0s7ok4uw	5390	5	Red	Red	NNP
cord-001835-0s7ok4uw	5390	6	Sea	Sea	NNP
cord-001835-0s7ok4uw	5390	7	brine	brine	NN
cord-001835-0s7ok4uw	5390	8	-	-	HYPH
cord-001835-0s7ok4uw	5390	9	pools	pool	NNS
cord-001835-0s7ok4uw	5390	10	:	:	:
cord-001835-0s7ok4uw	5390	11	new	new	JJ
cord-001835-0s7ok4uw	5390	12	potential	potential	JJ
cord-001835-0s7ok4uw	5390	13	polymerases	polymerase	NNS
cord-001835-0s7ok4uw	5390	14	for	for	IN
cord-001835-0s7ok4uw	5390	15	PCR	PCR	NNP
cord-001835-0s7ok4uw	5390	16	application	application	NN
cord-001835-0s7ok4uw	5390	17	Masateru	Masateru	NNP
cord-001835-0s7ok4uw	5390	18	Takahashi	Takahashi	NNP
cord-001835-0s7ok4uw	5390	19	1	1	CD
cord-001835-0s7ok4uw	5390	20	,	,	,
cord-001835-0s7ok4uw	5390	21	Etsuko	Etsuko	NNP
cord-001835-0s7ok4uw	5390	22	Kimura	Kimura	NNP
cord-001835-0s7ok4uw	5390	23	1	1	CD
cord-001835-0s7ok4uw	5390	24	,	,	,
cord-001835-0s7ok4uw	5390	25	Mohamed	Mohamed	NNP
cord-001835-0s7ok4uw	5390	26	Salem	Salem	NNP
cord-001835-0s7ok4uw	5390	27	1	1	CD
cord-001835-0s7ok4uw	5390	28	,	,	,
cord-001835-0s7ok4uw	5390	29	Ulrich	Ulrich	NNP
cord-001835-0s7ok4uw	5390	30	Stingl	Stingl	NNP
cord-001835-0s7ok4uw	5390	31	1	1	CD
cord-001835-0s7ok4uw	5390	32	,	,	,
cord-001835-0s7ok4uw	5390	33	Samir	Samir	NNP
cord-001835-0s7ok4uw	5390	34	Hamdan	Hamdan	NNP
cord-001835-0s7ok4uw	5390	35	1	1	CD
cord-001835-0s7ok4uw	5390	36	1	1	CD
cord-001835-0s7ok4uw	5390	37	Protein	Protein	NNP
cord-001835-0s7ok4uw	5390	38	Biotechnology	Biotechnology	NNP
cord-001835-0s7ok4uw	5391	1	The	the	DT
cord-001835-0s7ok4uw	5391	2	polymerase	polymerase	NN
cord-001835-0s7ok4uw	5391	3	chain	chain	NN
cord-001835-0s7ok4uw	5391	4	reaction	reaction	NN
cord-001835-0s7ok4uw	5391	5	(	(	-LRB-
cord-001835-0s7ok4uw	5391	6	PCR	PCR	NNP
cord-001835-0s7ok4uw	5391	7	)	)	-RRB-
cord-001835-0s7ok4uw	5391	8	is	be	VBZ
cord-001835-0s7ok4uw	5391	9	a	a	DT
cord-001835-0s7ok4uw	5391	10	key	key	JJ
cord-001835-0s7ok4uw	5391	11	tool	tool	NN
cord-001835-0s7ok4uw	5391	12	in	in	IN
cord-001835-0s7ok4uw	5391	13	medical	medical	JJ
cord-001835-0s7ok4uw	5391	14	and	and	CC
cord-001835-0s7ok4uw	5391	15	biological	biological	JJ
cord-001835-0s7ok4uw	5391	16	research	research	NN
cord-001835-0s7ok4uw	5391	17	.	.	.
cord-001835-0s7ok4uw	5392	1	The	the	DT
cord-001835-0s7ok4uw	5392	2	most	most	RBS
cord-001835-0s7ok4uw	5392	3	common	common	JJ
cord-001835-0s7ok4uw	5392	4	PCR	PCR	NNP
cord-001835-0s7ok4uw	5392	5	reaction	reaction	NN
cord-001835-0s7ok4uw	5392	6	relies	rely	VBZ
cord-001835-0s7ok4uw	5392	7	on	on	IN
cord-001835-0s7ok4uw	5392	8	the	the	DT
cord-001835-0s7ok4uw	5392	9	thermal	thermal	JJ
cord-001835-0s7ok4uw	5392	10	cycling	cycling	NN
cord-001835-0s7ok4uw	5392	11	method	method	NN
cord-001835-0s7ok4uw	5392	12	that	that	WDT
cord-001835-0s7ok4uw	5392	13	consists	consist	VBZ
cord-001835-0s7ok4uw	5392	14	of	of	IN
cord-001835-0s7ok4uw	5392	15	repeated	repeat	VBN
cord-001835-0s7ok4uw	5392	16	cycles	cycle	NNS
cord-001835-0s7ok4uw	5392	17	of	of	IN
cord-001835-0s7ok4uw	5392	18	heating	heating	NN
cord-001835-0s7ok4uw	5392	19	and	and	CC
cord-001835-0s7ok4uw	5392	20	cooling	cool	VBG
cord-001835-0s7ok4uw	5392	21	steps	step	NNS
cord-001835-0s7ok4uw	5392	22	for	for	IN
cord-001835-0s7ok4uw	5392	23	DNA	dna	NN
cord-001835-0s7ok4uw	5392	24	melting	melting	NN
cord-001835-0s7ok4uw	5392	25	and	and	CC
cord-001835-0s7ok4uw	5392	26	extension	extension	NN
cord-001835-0s7ok4uw	5392	27	by	by	IN
cord-001835-0s7ok4uw	5392	28	the	the	DT
cord-001835-0s7ok4uw	5392	29	DNA	dna	NN
cord-001835-0s7ok4uw	5392	30	polymerase	polymerase	NN
cord-001835-0s7ok4uw	5392	31	,	,	,
cord-001835-0s7ok4uw	5392	32	respectively	respectively	RB
cord-001835-0s7ok4uw	5392	33	.	.	.
cord-001835-0s7ok4uw	5393	1	The	the	DT
cord-001835-0s7ok4uw	5393	2	introduction	introduction	NN
cord-001835-0s7ok4uw	5393	3	of	of	IN
cord-001835-0s7ok4uw	5393	4	new	new	JJ
cord-001835-0s7ok4uw	5393	5	DNA	dna	NN
cord-001835-0s7ok4uw	5393	6	polymerases	polymerase	NNS
cord-001835-0s7ok4uw	5393	7	to	to	IN
cord-001835-0s7ok4uw	5393	8	the	the	DT
cord-001835-0s7ok4uw	5393	9	market	market	NN
cord-001835-0s7ok4uw	5393	10	is	be	VBZ
cord-001835-0s7ok4uw	5393	11	a	a	DT
cord-001835-0s7ok4uw	5393	12	major	major	JJ
cord-001835-0s7ok4uw	5393	13	area	area	NN
cord-001835-0s7ok4uw	5393	14	of	of	IN
cord-001835-0s7ok4uw	5393	15	development	development	NN
cord-001835-0s7ok4uw	5393	16	that	that	WDT
cord-001835-0s7ok4uw	5393	17	tremendously	tremendously	RB
cord-001835-0s7ok4uw	5393	18	helped	help	VBD
cord-001835-0s7ok4uw	5393	19	in	in	IN
cord-001835-0s7ok4uw	5393	20	improving	improve	VBG
cord-001835-0s7ok4uw	5393	21	the	the	DT
cord-001835-0s7ok4uw	5393	22	performance	performance	NN
cord-001835-0s7ok4uw	5393	23	and	and	CC
cord-001835-0s7ok4uw	5393	24	quality	quality	NN
cord-001835-0s7ok4uw	5393	25	of	of	IN
cord-001835-0s7ok4uw	5393	26	PCR	PCR	NNP
cord-001835-0s7ok4uw	5393	27	.	.	.
cord-001835-0s7ok4uw	5394	1	Nonetheless	nonetheless	RB
cord-001835-0s7ok4uw	5394	2	,	,	,
cord-001835-0s7ok4uw	5394	3	PCR	PCR	NNP
cord-001835-0s7ok4uw	5394	4	still	still	RB
cord-001835-0s7ok4uw	5394	5	requires	require	VBZ
cord-001835-0s7ok4uw	5394	6	optimization	optimization	NN
cord-001835-0s7ok4uw	5394	7	of	of	IN
cord-001835-0s7ok4uw	5394	8	salt	salt	NN
cord-001835-0s7ok4uw	5394	9	and	and	CC
cord-001835-0s7ok4uw	5394	10	metal	metal	NN
cord-001835-0s7ok4uw	5394	11	ion	ion	NN
cord-001835-0s7ok4uw	5394	12	concentrations	concentration	NNS
cord-001835-0s7ok4uw	5394	13	leaving	leave	VBG
cord-001835-0s7ok4uw	5394	14	a	a	DT
cord-001835-0s7ok4uw	5394	15	room	room	NN
cord-001835-0s7ok4uw	5394	16	in	in	IN
cord-001835-0s7ok4uw	5394	17	the	the	DT
cord-001835-0s7ok4uw	5394	18	market	market	NN
cord-001835-0s7ok4uw	5394	19	for	for	IN
cord-001835-0s7ok4uw	5394	20	introducing	introduce	VBG
cord-001835-0s7ok4uw	5394	21	new	new	JJ
cord-001835-0s7ok4uw	5394	22	DNA	dna	NN
cord-001835-0s7ok4uw	5394	23	polymerases	polymerase	NNS
cord-001835-0s7ok4uw	5394	24	that	that	WDT
cord-001835-0s7ok4uw	5394	25	are	be	VBP
cord-001835-0s7ok4uw	5394	26	robuster	robuster	NN
cord-001835-0s7ok4uw	5394	27	in	in	IN
cord-001835-0s7ok4uw	5394	28	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5394	29	salt	salt	NN
cord-001835-0s7ok4uw	5394	30	and	and	CC
cord-001835-0s7ok4uw	5394	31	metal	metal	NN
cord-001835-0s7ok4uw	5394	32	ion	ion	NN
cord-001835-0s7ok4uw	5394	33	concentration	concentration	NN
cord-001835-0s7ok4uw	5394	34	dependence	dependence	NN
cord-001835-0s7ok4uw	5394	35	.	.	.
cord-001835-0s7ok4uw	5395	1	In	in	IN
cord-001835-0s7ok4uw	5395	2	this	this	DT
cord-001835-0s7ok4uw	5395	3	study	study	NN
cord-001835-0s7ok4uw	5395	4	,	,	,
cord-001835-0s7ok4uw	5395	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	5395	6	will	will	MD
cord-001835-0s7ok4uw	5395	7	present	present	VB
cord-001835-0s7ok4uw	5395	8	the	the	DT
cord-001835-0s7ok4uw	5395	9	characterization	characterization	NN
cord-001835-0s7ok4uw	5395	10	of	of	IN
cord-001835-0s7ok4uw	5395	11	a	a	DT
cord-001835-0s7ok4uw	5395	12	novel	novel	JJ
cord-001835-0s7ok4uw	5395	13	archaeal	archaeal	JJ
cord-001835-0s7ok4uw	5395	14	DNA	dna	NN
cord-001835-0s7ok4uw	5395	15	polymerase	polymerase	NN
cord-001835-0s7ok4uw	5395	16	from	from	IN
cord-001835-0s7ok4uw	5395	17	the	the	DT
cord-001835-0s7ok4uw	5395	18	Red	Red	NNP
cord-001835-0s7ok4uw	5395	19	Sea	Sea	NNP
cord-001835-0s7ok4uw	5395	20	brine	brine	NN
cord-001835-0s7ok4uw	5395	21	-	-	HYPH
cord-001835-0s7ok4uw	5395	22	pool	pool	NN
cord-001835-0s7ok4uw	5395	23	(	(	-LRB-
cord-001835-0s7ok4uw	5395	24	termed	term	VBN
cord-001835-0s7ok4uw	5395	25	BR3	BR3	NNP
cord-001835-0s7ok4uw	5395	26	)	)	-RRB-
cord-001835-0s7ok4uw	5395	27	and	and	CC
cord-001835-0s7ok4uw	5395	28	demonstrate	demonstrate	VB
cord-001835-0s7ok4uw	5395	29	how	how	WRB
cord-001835-0s7ok4uw	5395	30	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5395	31	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5395	32	activity	activity	NN
cord-001835-0s7ok4uw	5395	33	reflects	reflect	VBZ
cord-001835-0s7ok4uw	5395	34	on	on	IN
cord-001835-0s7ok4uw	5395	35	every	every	DT
cord-001835-0s7ok4uw	5395	36	aspects	aspect	NNS
cord-001835-0s7ok4uw	5395	37	of	of	IN
cord-001835-0s7ok4uw	5395	38	the	the	DT
cord-001835-0s7ok4uw	5395	39	environment	environment	NN
cord-001835-0s7ok4uw	5395	40	of	of	IN
cord-001835-0s7ok4uw	5395	41	the	the	DT
cord-001835-0s7ok4uw	5395	42	brine	brine	NN
cord-001835-0s7ok4uw	5395	43	-	-	HYPH
cord-001835-0s7ok4uw	5395	44	pool	pool	NN
cord-001835-0s7ok4uw	5396	1	-high	-high	JJ
cord-001835-0s7ok4uw	5396	2	tolerance	tolerance	NN
cord-001835-0s7ok4uw	5396	3	to	to	IN
cord-001835-0s7ok4uw	5396	4	concentrations	concentration	NNS
cord-001835-0s7ok4uw	5396	5	and	and	CC
cord-001835-0s7ok4uw	5396	6	types	type	NNS
cord-001835-0s7ok4uw	5396	7	of	of	IN
cord-001835-0s7ok4uw	5396	8	salts	salt	NNS
cord-001835-0s7ok4uw	5396	9	and	and	CC
cord-001835-0s7ok4uw	5396	10	metal	metal	NN
cord-001835-0s7ok4uw	5396	11	ions	ion	NNS
cord-001835-0s7ok4uw	5396	12	including	include	VBG
cord-001835-0s7ok4uw	5396	13	utilization	utilization	NN
cord-001835-0s7ok4uw	5396	14	of	of	IN
cord-001835-0s7ok4uw	5396	15	Zn21	Zn21	NNP
cord-001835-0s7ok4uw	5396	16	ions	ion	NNS
cord-001835-0s7ok4uw	5396	17	in	in	IN
cord-001835-0s7ok4uw	5396	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5396	19	active	active	JJ
cord-001835-0s7ok4uw	5396	20	site	site	NN
cord-001835-0s7ok4uw	5396	21	.	.	.
cord-001835-0s7ok4uw	5397	1	These	these	DT
cord-001835-0s7ok4uw	5397	2	results	result	NNS
cord-001835-0s7ok4uw	5397	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	5397	4	that	that	IN
cord-001835-0s7ok4uw	5397	5	the	the	DT
cord-001835-0s7ok4uw	5397	6	brine	brine	NN
cord-001835-0s7ok4uw	5397	7	-	-	HYPH
cord-001835-0s7ok4uw	5397	8	pool	pool	NN
cord-001835-0s7ok4uw	5397	9	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	5397	10	are	be	VBP
cord-001835-0s7ok4uw	5397	11	likely	likely	JJ
cord-001835-0s7ok4uw	5397	12	to	to	TO
cord-001835-0s7ok4uw	5397	13	contain	contain	VB
cord-001835-0s7ok4uw	5397	14	novel	novel	JJ
cord-001835-0s7ok4uw	5397	15	chemical	chemical	NN
cord-001835-0s7ok4uw	5397	16	pathways	pathway	NNS
cord-001835-0s7ok4uw	5397	17	to	to	TO
cord-001835-0s7ok4uw	5397	18	deal	deal	VB
cord-001835-0s7ok4uw	5397	19	with	with	IN
cord-001835-0s7ok4uw	5397	20	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5397	21	exterior	exterior	JJ
cord-001835-0s7ok4uw	5397	22	harsh	harsh	JJ
cord-001835-0s7ok4uw	5397	23	conditions	condition	NNS
cord-001835-0s7ok4uw	5397	24	.	.	.
cord-001835-0s7ok4uw	5398	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5398	2	will	will	MD
cord-001835-0s7ok4uw	5398	3	further	further	RB
cord-001835-0s7ok4uw	5398	4	show	show	VB
cord-001835-0s7ok4uw	5398	5	the	the	DT
cord-001835-0s7ok4uw	5398	6	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5398	7	of	of	IN
cord-001835-0s7ok4uw	5398	8	BR3	BR3	NNP
cord-001835-0s7ok4uw	5398	9	polymerase	polymerase	NN
cord-001835-0s7ok4uw	5398	10	how	how	WRB
cord-001835-0s7ok4uw	5398	11	it	-PRON-	PRP
cord-001835-0s7ok4uw	5398	12	was	be	VBD
cord-001835-0s7ok4uw	5398	13	adjusted	adjust	VBN
cord-001835-0s7ok4uw	5398	14	to	to	TO
cord-001835-0s7ok4uw	5398	15	be	be	VB
cord-001835-0s7ok4uw	5398	16	active	active	JJ
cord-001835-0s7ok4uw	5398	17	in	in	IN
cord-001835-0s7ok4uw	5398	18	harsh	harsh	JJ
cord-001835-0s7ok4uw	5398	19	condition	condition	NN
cord-001835-0s7ok4uw	5398	20	.	.	.
cord-001835-0s7ok4uw	5399	1	Structural	structural	JJ
cord-001835-0s7ok4uw	5399	2	basis	basis	NN
cord-001835-0s7ok4uw	5399	3	for	for	IN
cord-001835-0s7ok4uw	5399	4	the	the	DT
cord-001835-0s7ok4uw	5399	5	identification	identification	NN
cord-001835-0s7ok4uw	5399	6	of	of	IN
cord-001835-0s7ok4uw	5399	7	the	the	DT
cord-001835-0s7ok4uw	5399	8	n	n	JJ
cord-001835-0s7ok4uw	5399	9	-	-	HYPH
cord-001835-0s7ok4uw	5399	10	terminal	terminal	JJ
cord-001835-0s7ok4uw	5399	11	domain	domain	NN
cord-001835-0s7ok4uw	5399	12	of	of	IN
cord-001835-0s7ok4uw	5399	13	coronavirus	coronavirus	NN
cord-001835-0s7ok4uw	5399	14	nucleocapsid	nucleocapsid	NN
cord-001835-0s7ok4uw	5399	15	protein	protein	NN
cord-001835-0s7ok4uw	5399	16	as	as	IN
cord-001835-0s7ok4uw	5399	17	an	an	DT
cord-001835-0s7ok4uw	5399	18	antiviral	antiviral	JJ
cord-001835-0s7ok4uw	5399	19	target	target	NN
cord-001835-0s7ok4uw	5399	20	Ming	Ming	NNP
cord-001835-0s7ok4uw	5399	21	-	-	HYPH
cord-001835-0s7ok4uw	5399	22	Hon	Hon	NNP
cord-001835-0s7ok4uw	5399	23	Hou	Hou	NNP
cord-001835-0s7ok4uw	5399	24	1	1	CD
cord-001835-0s7ok4uw	5399	25	,	,	,
cord-001835-0s7ok4uw	5399	26	Shing	Shing	NNP
cord-001835-0s7ok4uw	5399	27	-	-	HYPH
cord-001835-0s7ok4uw	5399	28	Yen	Yen	NNP
cord-001835-0s7ok4uw	5399	29	Lin	Lin	NNP
cord-001835-0s7ok4uw	5399	30	1	1	CD
cord-001835-0s7ok4uw	5400	1	,	,	,
cord-001835-0s7ok4uw	5400	2	Chia	Chia	NNP
cord-001835-0s7ok4uw	5400	3	-	-	HYPH
cord-001835-0s7ok4uw	5400	4	Ling	Ling	NNP
cord-001835-0s7ok4uw	5400	5	Liu	Liu	NNP
cord-001835-0s7ok4uw	5400	6	1	1	CD
cord-001835-0s7ok4uw	5400	7	,	,	,
cord-001835-0s7ok4uw	5401	1	Yu	Yu	NNP
cord-001835-0s7ok4uw	5401	2	-	-	HYPH
cord-001835-0s7ok4uw	5401	3	Ming	Ming	NNP
cord-001835-0s7ok4uw	5401	4	Chang	Chang	NNP
cord-001835-0s7ok4uw	5401	5	2	2	CD
cord-001835-0s7ok4uw	5401	6	,	,	,
cord-001835-0s7ok4uw	5401	7	Jincun	Jincun	NNP
cord-001835-0s7ok4uw	5401	8	Zhao	Zhao	NNP
cord-001835-0s7ok4uw	5401	9	3	3	CD
cord-001835-0s7ok4uw	5401	10	,	,	,
cord-001835-0s7ok4uw	5401	11	Stanley	Stanley	NNP
cord-001835-0s7ok4uw	5401	12	Perlman	Perlman	NNP
cord-001835-0s7ok4uw	5401	13	3	3	CD
cord-001835-0s7ok4uw	5401	14	1	1	CD
cord-001835-0s7ok4uw	5401	15	Institute	Institute	NNP
cord-001835-0s7ok4uw	5401	16	of	of	IN
cord-001835-0s7ok4uw	5401	17	Genomics	Genomics	NNP
cord-001835-0s7ok4uw	5401	18	and	and	CC
cord-001835-0s7ok4uw	5401	19	Bioinformatics	Bioinformatics	NNP
cord-001835-0s7ok4uw	5401	20	,	,	,
cord-001835-0s7ok4uw	5401	21	National	National	NNP
cord-001835-0s7ok4uw	5401	22	Chung	Chung	NNP
cord-001835-0s7ok4uw	5401	23	Hsing	Hsing	NNP
cord-001835-0s7ok4uw	5401	24	University	University	NNP
cord-001835-0s7ok4uw	5401	25	.	.	.
cord-001835-0s7ok4uw	5402	1	,	,	,
cord-001835-0s7ok4uw	5402	2	2	2	CD
cord-001835-0s7ok4uw	5402	3	Institute	Institute	NNP
cord-001835-0s7ok4uw	5402	4	of	of	IN
cord-001835-0s7ok4uw	5402	5	Biological	Biological	NNP
cord-001835-0s7ok4uw	5402	6	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	5402	7	,	,	,
cord-001835-0s7ok4uw	5402	8	Academia	Academia	NNP
cord-001835-0s7ok4uw	5402	9	Sinica	Sinica	NNP
cord-001835-0s7ok4uw	5402	10	.	.	.
cord-001835-0s7ok4uw	5402	11	,	,	,
cord-001835-0s7ok4uw	5402	12	3	3	CD
cord-001835-0s7ok4uw	5402	13	Department	Department	NNP
cord-001835-0s7ok4uw	5402	14	of	of	IN
cord-001835-0s7ok4uw	5402	15	Microbiology	Microbiology	NNP
cord-001835-0s7ok4uw	5402	16	,	,	,
cord-001835-0s7ok4uw	5402	17	The	the	DT
cord-001835-0s7ok4uw	5402	18	University	University	NNP
cord-001835-0s7ok4uw	5402	19	of	of	IN
cord-001835-0s7ok4uw	5402	20	Iowa	Iowa	NNP
cord-001835-0s7ok4uw	5402	21	Drug	Drug	NNP
cord-001835-0s7ok4uw	5402	22	Discovery	Discovery	NNP
cord-001835-0s7ok4uw	5402	23	Coronaviruses	Coronaviruses	NNP
cord-001835-0s7ok4uw	5402	24	(	(	-LRB-
cord-001835-0s7ok4uw	5402	25	CoVs	CoVs	NNP
cord-001835-0s7ok4uw	5402	26	)	)	-RRB-
cord-001835-0s7ok4uw	5402	27	cause	cause	VB
cord-001835-0s7ok4uw	5402	28	numerous	numerous	JJ
cord-001835-0s7ok4uw	5402	29	diseases	disease	NNS
cord-001835-0s7ok4uw	5402	30	,	,	,
cord-001835-0s7ok4uw	5402	31	including	include	VBG
cord-001835-0s7ok4uw	5402	32	Middle	Middle	NNP
cord-001835-0s7ok4uw	5402	33	East	East	NNP
cord-001835-0s7ok4uw	5402	34	respiratory	respiratory	JJ
cord-001835-0s7ok4uw	5402	35	syndrome	syndrome	NN
cord-001835-0s7ok4uw	5402	36	and	and	CC
cord-001835-0s7ok4uw	5402	37	severe	severe	JJ
cord-001835-0s7ok4uw	5402	38	acute	acute	JJ
cord-001835-0s7ok4uw	5402	39	respiratory	respiratory	JJ
cord-001835-0s7ok4uw	5402	40	syndrome	syndrome	NN
cord-001835-0s7ok4uw	5402	41	,	,	,
cord-001835-0s7ok4uw	5402	42	generating	generate	VBG
cord-001835-0s7ok4uw	5402	43	significant	significant	JJ
cord-001835-0s7ok4uw	5402	44	health	health	NN
cord-001835-0s7ok4uw	5402	45	-	-	HYPH
cord-001835-0s7ok4uw	5402	46	related	relate	VBN
cord-001835-0s7ok4uw	5402	47	and	and	CC
cord-001835-0s7ok4uw	5402	48	economic	economic	JJ
cord-001835-0s7ok4uw	5402	49	consequences	consequence	NNS
cord-001835-0s7ok4uw	5402	50	.	.	.
cord-001835-0s7ok4uw	5403	1	CoVs	CoVs	NNP
cord-001835-0s7ok4uw	5403	2	encode	encode	VBP
cord-001835-0s7ok4uw	5403	3	the	the	DT
cord-001835-0s7ok4uw	5403	4	nucleocapsid	nucleocapsid	NN
cord-001835-0s7ok4uw	5403	5	(	(	-LRB-
cord-001835-0s7ok4uw	5403	6	N	N	NNP
cord-001835-0s7ok4uw	5403	7	)	)	-RRB-
cord-001835-0s7ok4uw	5403	8	protein	protein	NN
cord-001835-0s7ok4uw	5403	9	,	,	,
cord-001835-0s7ok4uw	5403	10	a	a	DT
cord-001835-0s7ok4uw	5403	11	major	major	JJ
cord-001835-0s7ok4uw	5403	12	structural	structural	JJ
cord-001835-0s7ok4uw	5403	13	protein	protein	NN
cord-001835-0s7ok4uw	5403	14	that	that	WDT
cord-001835-0s7ok4uw	5403	15	plays	play	VBZ
cord-001835-0s7ok4uw	5403	16	multiple	multiple	JJ
cord-001835-0s7ok4uw	5403	17	roles	role	NNS
cord-001835-0s7ok4uw	5403	18	in	in	IN
cord-001835-0s7ok4uw	5403	19	the	the	DT
cord-001835-0s7ok4uw	5403	20	virus	virus	NN
cord-001835-0s7ok4uw	5403	21	replication	replication	NN
cord-001835-0s7ok4uw	5403	22	cycle	cycle	NN
cord-001835-0s7ok4uw	5403	23	and	and	CC
cord-001835-0s7ok4uw	5403	24	forms	form	VBZ
cord-001835-0s7ok4uw	5403	25	a	a	DT
cord-001835-0s7ok4uw	5403	26	ribonucleoprotein	ribonucleoprotein	NN
cord-001835-0s7ok4uw	5403	27	complex	complex	NN
cord-001835-0s7ok4uw	5403	28	with	with	IN
cord-001835-0s7ok4uw	5403	29	the	the	DT
cord-001835-0s7ok4uw	5403	30	viral	viral	JJ
cord-001835-0s7ok4uw	5403	31	RNA	RNA	NNP
cord-001835-0s7ok4uw	5403	32	through	through	IN
cord-001835-0s7ok4uw	5403	33	the	the	DT
cord-001835-0s7ok4uw	5403	34	N	N	NNP
cord-001835-0s7ok4uw	5403	35	protein	protein	NN
cord-001835-0s7ok4uw	5403	36	's	's	POS
cord-001835-0s7ok4uw	5403	37	Nterminal	Nterminal	NNP
cord-001835-0s7ok4uw	5403	38	domain	domain	NN
cord-001835-0s7ok4uw	5403	39	(	(	-LRB-
cord-001835-0s7ok4uw	5403	40	N	N	NNP
cord-001835-0s7ok4uw	5403	41	-	-	HYPH
cord-001835-0s7ok4uw	5403	42	NTD	NTD	NNP
cord-001835-0s7ok4uw	5403	43	)	)	-RRB-
cord-001835-0s7ok4uw	5403	44	.	.	.
cord-001835-0s7ok4uw	5404	1	Using	use	VBG
cord-001835-0s7ok4uw	5404	2	human	human	JJ
cord-001835-0s7ok4uw	5404	3	CoV	cov	NN
cord-001835-0s7ok4uw	5404	4	-	-	:
cord-001835-0s7ok4uw	5404	5	OC43	OC43	NNP
cord-001835-0s7ok4uw	5404	6	(	(	-LRB-
cord-001835-0s7ok4uw	5404	7	HCoV	HCoV	NNP
cord-001835-0s7ok4uw	5404	8	-	-	HYPH
cord-001835-0s7ok4uw	5404	9	OC43	OC43	NNP
cord-001835-0s7ok4uw	5404	10	)	)	-RRB-
cord-001835-0s7ok4uw	5404	11	as	as	IN
cord-001835-0s7ok4uw	5404	12	a	a	DT
cord-001835-0s7ok4uw	5404	13	model	model	NN
cord-001835-0s7ok4uw	5404	14	for	for	IN
cord-001835-0s7ok4uw	5404	15	CoV	CoV	NNP
cord-001835-0s7ok4uw	5404	16	,	,	,
cord-001835-0s7ok4uw	5404	17	we	-PRON-	PRP
cord-001835-0s7ok4uw	5404	18	present	present	VBP
cord-001835-0s7ok4uw	5404	19	the	the	DT
cord-001835-0s7ok4uw	5404	20	3D	3d	JJ
cord-001835-0s7ok4uw	5404	21	structure	structure	NN
cord-001835-0s7ok4uw	5404	22	of	of	IN
cord-001835-0s7ok4uw	5404	23	HCoV	HCoV	NNP
cord-001835-0s7ok4uw	5404	24	-	-	HYPH
cord-001835-0s7ok4uw	5404	25	OC43	OC43	NNP
cord-001835-0s7ok4uw	5404	26	N	N	NNP
cord-001835-0s7ok4uw	5404	27	-	-	HYPH
cord-001835-0s7ok4uw	5404	28	NTD	NTD	NNP
cord-001835-0s7ok4uw	5404	29	complexed	complexe	VBN
cord-001835-0s7ok4uw	5404	30	with	with	IN
cord-001835-0s7ok4uw	5404	31	ribonucleoside	ribonucleoside	JJ
cord-001835-0s7ok4uw	5404	32	5'-monophosphates	5'-monophosphates	NNP
cord-001835-0s7ok4uw	5404	33	to	to	TO
cord-001835-0s7ok4uw	5404	34	identify	identify	VB
cord-001835-0s7ok4uw	5404	35	a	a	DT
cord-001835-0s7ok4uw	5404	36	distinct	distinct	JJ
cord-001835-0s7ok4uw	5404	37	ribonucleotide	ribonucleotide	NN
cord-001835-0s7ok4uw	5404	38	-	-	HYPH
cord-001835-0s7ok4uw	5404	39	binding	bind	VBG
cord-001835-0s7ok4uw	5404	40	pocket	pocket	NN
cord-001835-0s7ok4uw	5404	41	.	.	.
cord-001835-0s7ok4uw	5405	1	By	by	IN
cord-001835-0s7ok4uw	5405	2	targeting	target	VBG
cord-001835-0s7ok4uw	5405	3	this	this	DT
cord-001835-0s7ok4uw	5405	4	pocket	pocket	NN
cord-001835-0s7ok4uw	5405	5	,	,	,
cord-001835-0s7ok4uw	5405	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	5405	7	identified	identify	VBD
cord-001835-0s7ok4uw	5405	8	and	and	CC
cord-001835-0s7ok4uw	5405	9	developed	develop	VBD
cord-001835-0s7ok4uw	5405	10	a	a	DT
cord-001835-0s7ok4uw	5405	11	new	new	JJ
cord-001835-0s7ok4uw	5405	12	coronavirus	coronavirus	NN
cord-001835-0s7ok4uw	5405	13	N	n	CD
cord-001835-0s7ok4uw	5405	14	protein	protein	NN
cord-001835-0s7ok4uw	5405	15	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	5405	16	,	,	,
cord-001835-0s7ok4uw	5405	17	N-(6-oxo-5,6-dihydrophenanthridin-2-yl)(N	N-(6-oxo-5,6-dihydrophenanthridin-2-yl)(N	NNP
cord-001835-0s7ok4uw	5405	18	,	,	,
cord-001835-0s7ok4uw	5405	19	N	N	NNP
cord-001835-0s7ok4uw	5405	20	-	-	HYPH
cord-001835-0s7ok4uw	5405	21	dimethylamino)acetamide	dimethylamino)acetamide	NNP
cord-001835-0s7ok4uw	5405	22	hydrochloride	hydrochloride	NN
cord-001835-0s7ok4uw	5405	23	(	(	-LRB-
cord-001835-0s7ok4uw	5405	24	PJ34	PJ34	NNP
cord-001835-0s7ok4uw	5405	25	)	)	-RRB-
cord-001835-0s7ok4uw	5405	26	,	,	,
cord-001835-0s7ok4uw	5405	27	using	use	VBG
cord-001835-0s7ok4uw	5405	28	virtual	virtual	JJ
cord-001835-0s7ok4uw	5405	29	screening	screening	NN
cord-001835-0s7ok4uw	5405	30	;	;	:
cord-001835-0s7ok4uw	5405	31	this	this	DT
cord-001835-0s7ok4uw	5405	32	inhibitor	inhibitor	NN
cord-001835-0s7ok4uw	5405	33	reduced	reduce	VBD
cord-001835-0s7ok4uw	5405	34	the	the	DT
cord-001835-0s7ok4uw	5405	35	N	N	NNP
cord-001835-0s7ok4uw	5405	36	protein	protein	NN
cord-001835-0s7ok4uw	5405	37	's	's	POS
cord-001835-0s7ok4uw	5405	38	RNA	RNA	NNP
cord-001835-0s7ok4uw	5405	39	-	-	HYPH
cord-001835-0s7ok4uw	5405	40	binding	bind	VBG
cord-001835-0s7ok4uw	5405	41	affinity	affinity	NN
cord-001835-0s7ok4uw	5405	42	and	and	CC
cord-001835-0s7ok4uw	5405	43	hindered	hinder	VBN
cord-001835-0s7ok4uw	5405	44	viral	viral	JJ
cord-001835-0s7ok4uw	5405	45	replication	replication	NN
cord-001835-0s7ok4uw	5405	46	.	.	.
cord-001835-0s7ok4uw	5406	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5406	2	also	also	RB
cord-001835-0s7ok4uw	5406	3	determined	determine	VBD
cord-001835-0s7ok4uw	5406	4	the	the	DT
cord-001835-0s7ok4uw	5406	5	crystal	crystal	JJ
cord-001835-0s7ok4uw	5406	6	structure	structure	NN
cord-001835-0s7ok4uw	5406	7	of	of	IN
cord-001835-0s7ok4uw	5406	8	the	the	DT
cord-001835-0s7ok4uw	5406	9	N	N	NNP
cord-001835-0s7ok4uw	5406	10	-	-	HYPH
cord-001835-0s7ok4uw	5406	11	NTD	NTD	NNP
cord-001835-0s7ok4uw	5406	12	-	-	HYPH
cord-001835-0s7ok4uw	5406	13	PJ34	PJ34	NNP
cord-001835-0s7ok4uw	5406	14	complex	complex	NN
cord-001835-0s7ok4uw	5406	15	.	.	.
cord-001835-0s7ok4uw	5407	1	On	on	IN
cord-001835-0s7ok4uw	5407	2	the	the	DT
cord-001835-0s7ok4uw	5407	3	basis	basis	NN
cord-001835-0s7ok4uw	5407	4	of	of	IN
cord-001835-0s7ok4uw	5407	5	these	these	DT
cord-001835-0s7ok4uw	5407	6	findings	finding	NNS
cord-001835-0s7ok4uw	5407	7	,	,	,
cord-001835-0s7ok4uw	5407	8	we	-PRON-	PRP
cord-001835-0s7ok4uw	5407	9	propose	propose	VBP
cord-001835-0s7ok4uw	5407	10	guidelines	guideline	NNS
cord-001835-0s7ok4uw	5407	11	for	for	IN
cord-001835-0s7ok4uw	5407	12	developing	develop	VBG
cord-001835-0s7ok4uw	5407	13	new	new	JJ
cord-001835-0s7ok4uw	5407	14	N	n	CD
cord-001835-0s7ok4uw	5407	15	protein	protein	NN
cord-001835-0s7ok4uw	5407	16	-	-	HYPH
cord-001835-0s7ok4uw	5407	17	based	base	VBN
cord-001835-0s7ok4uw	5407	18	antiviral	antiviral	JJ
cord-001835-0s7ok4uw	5407	19	agents	agent	NNS
cord-001835-0s7ok4uw	5407	20	that	that	WDT
cord-001835-0s7ok4uw	5407	21	target	target	VBP
cord-001835-0s7ok4uw	5407	22	CoVs	CoVs	NNP
cord-001835-0s7ok4uw	5407	23	.	.	.
cord-001835-0s7ok4uw	5408	1	Thermal	thermal	JJ
cord-001835-0s7ok4uw	5408	2	and	and	CC
cord-001835-0s7ok4uw	5408	3	structural	structural	JJ
cord-001835-0s7ok4uw	5408	4	stability	stability	NN
cord-001835-0s7ok4uw	5408	5	of	of	IN
cord-001835-0s7ok4uw	5408	6	ß	ß	NN
cord-001835-0s7ok4uw	5408	7	-	-	HYPH
cord-001835-0s7ok4uw	5408	8	Glucosidases	Glucosidases	NNP
cord-001835-0s7ok4uw	5408	9	GH1	GH1	NNP
cord-001835-0s7ok4uw	5408	10	Maira	Maira	NNP
cord-001835-0s7ok4uw	5408	11	Artischeff	Artischeff	NNP
cord-001835-0s7ok4uw	5408	12	Frutuoso	Frutuoso	NNP
cord-001835-0s7ok4uw	5408	13	1	1	CD
cord-001835-0s7ok4uw	5408	14	1	1	CD
cord-001835-0s7ok4uw	5408	15	Departamento	Departamento	NNP
cord-001835-0s7ok4uw	5408	16	de	de	NNP
cord-001835-0s7ok4uw	5408	17	Bioqu	Bioqu	NNP
cord-001835-0s7ok4uw	5408	18	ımica	ımica	NNP
cord-001835-0s7ok4uw	5408	19	do	do	VBP
cord-001835-0s7ok4uw	5408	20	Instituto	Instituto	NNP
cord-001835-0s7ok4uw	5408	21	de	de	NNP
cord-001835-0s7ok4uw	5408	22	Qu	Qu	NNP
cord-001835-0s7ok4uw	5408	23	ımica	ımica	NNP
cord-001835-0s7ok4uw	5408	24	da	da	NNP
cord-001835-0s7ok4uw	5408	25	Universidade	Universidade	NNP
cord-001835-0s7ok4uw	5408	26	de	de	NNP
cord-001835-0s7ok4uw	5408	27	São	São	NNP
cord-001835-0s7ok4uw	5408	28	Paulo	Paulo	NNP
cord-001835-0s7ok4uw	5408	29	Enzymology	Enzymology	NNP
cord-001835-0s7ok4uw	5409	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5409	2	compared	compare	VBD
cord-001835-0s7ok4uw	5409	3	the	the	DT
cord-001835-0s7ok4uw	5409	4	stability	stability	NN
cord-001835-0s7ok4uw	5409	5	of	of	IN
cord-001835-0s7ok4uw	5409	6	thermophilic	thermophilic	JJ
cord-001835-0s7ok4uw	5409	7	b	b	NN
cord-001835-0s7ok4uw	5409	8	-	-	HYPH
cord-001835-0s7ok4uw	5409	9	glucosidases	glucosidase	NNS
cord-001835-0s7ok4uw	5409	10	GH1	GH1	NNP
cord-001835-0s7ok4uw	5409	11	to	to	IN
cord-001835-0s7ok4uw	5409	12	mesophilic	mesophilic	NNP
cord-001835-0s7ok4uw	5409	13	ones	one	NNS
cord-001835-0s7ok4uw	5409	14	in	in	IN
cord-001835-0s7ok4uw	5409	15	the	the	DT
cord-001835-0s7ok4uw	5409	16	presence	presence	NN
cord-001835-0s7ok4uw	5409	17	of	of	IN
cord-001835-0s7ok4uw	5409	18	denaturants	denaturant	NNS
cord-001835-0s7ok4uw	5409	19	as	as	IN
cord-001835-0s7ok4uw	5409	20	urea	urea	NN
cord-001835-0s7ok4uw	5409	21	and	and	CC
cord-001835-0s7ok4uw	5409	22	high	high	JJ
cord-001835-0s7ok4uw	5409	23	temperature	temperature	NN
cord-001835-0s7ok4uw	5409	24	by	by	IN
cord-001835-0s7ok4uw	5409	25	following	follow	VBG
cord-001835-0s7ok4uw	5409	26	the	the	DT
cord-001835-0s7ok4uw	5409	27	transitions	transition	NNS
cord-001835-0s7ok4uw	5409	28	between	between	IN
cord-001835-0s7ok4uw	5409	29	the	the	DT
cord-001835-0s7ok4uw	5409	30	native	native	JJ
cord-001835-0s7ok4uw	5409	31	and	and	CC
cord-001835-0s7ok4uw	5409	32	unfolded	unfold	VBD
cord-001835-0s7ok4uw	5409	33	states	state	NNS
cord-001835-0s7ok4uw	5409	34	by	by	IN
cord-001835-0s7ok4uw	5409	35	tryptophan	tryptophan	NN
cord-001835-0s7ok4uw	5409	36	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	5409	37	,	,	,
cord-001835-0s7ok4uw	5409	38	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5409	39	activity	activity	NN
cord-001835-0s7ok4uw	5409	40	and	and	CC
cord-001835-0s7ok4uw	5409	41	differential	differential	JJ
cord-001835-0s7ok4uw	5409	42	scanning	scanning	NN
cord-001835-0s7ok4uw	5409	43	fluorimetry	fluorimetry	NN
cord-001835-0s7ok4uw	5409	44	(	(	-LRB-
cord-001835-0s7ok4uw	5409	45	DSF	DSF	NNP
cord-001835-0s7ok4uw	5409	46	)	)	-RRB-
cord-001835-0s7ok4uw	5409	47	.	.	.
cord-001835-0s7ok4uw	5410	1	The	the	DT
cord-001835-0s7ok4uw	5410	2	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5410	3	b	b	NN
cord-001835-0s7ok4uw	5410	4	-	-	HYPH
cord-001835-0s7ok4uw	5410	5	glucosidases	glucosidases	NNP
cord-001835-0s7ok4uw	5410	6	(	(	-LRB-
cord-001835-0s7ok4uw	5410	7	bglA	bglA	NNP
cord-001835-0s7ok4uw	5410	8	)	)	-RRB-
cord-001835-0s7ok4uw	5410	9	and	and	CC
cord-001835-0s7ok4uw	5410	10	(	(	-LRB-
cord-001835-0s7ok4uw	5410	11	bglB	bglb	CD
cord-001835-0s7ok4uw	5410	12	)	)	-RRB-
cord-001835-0s7ok4uw	5410	13	of	of	IN
cord-001835-0s7ok4uw	5410	14	the	the	DT
cord-001835-0s7ok4uw	5410	15	mesophile	mesophile	NN
cord-001835-0s7ok4uw	5411	1	Paenibacillus	Paenibacillus	NNP
cord-001835-0s7ok4uw	5411	2	polimyxa	polimyxa	NN
cord-001835-0s7ok4uw	5411	3	and	and	CC
cord-001835-0s7ok4uw	5411	4	bglucosidase	bglucosidase	NNP
cord-001835-0s7ok4uw	5411	5	(	(	-LRB-
cord-001835-0s7ok4uw	5411	6	bglThm	bglThm	NNP
cord-001835-0s7ok4uw	5411	7	)	)	-RRB-
cord-001835-0s7ok4uw	5411	8	of	of	IN
cord-001835-0s7ok4uw	5411	9	the	the	DT
cord-001835-0s7ok4uw	5411	10	thermophile	thermophile	JJ
cord-001835-0s7ok4uw	5411	11	Thermotoga	Thermotoga	NNP
cord-001835-0s7ok4uw	5411	12	maritima	maritima	NN
cord-001835-0s7ok4uw	5411	13	were	be	VBD
cord-001835-0s7ok4uw	5411	14	expressed	express	VBN
cord-001835-0s7ok4uw	5411	15	as	as	IN
cord-001835-0s7ok4uw	5411	16	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	5411	17	proteins	protein	NNS
cord-001835-0s7ok4uw	5411	18	in	in	IN
cord-001835-0s7ok4uw	5411	19	NovaBlue	NovaBlue	NNP
cord-001835-0s7ok4uw	5411	20	(	(	-LRB-
cord-001835-0s7ok4uw	5411	21	DE3	DE3	NNP
cord-001835-0s7ok4uw	5411	22	)	)	-RRB-
cord-001835-0s7ok4uw	5411	23	and	and	CC
cord-001835-0s7ok4uw	5411	24	purified	purify	VBN
cord-001835-0s7ok4uw	5411	25	by	by	IN
cord-001835-0s7ok4uw	5411	26	affinity	affinity	NN
cord-001835-0s7ok4uw	5411	27	chromatography	chromatography	NN
cord-001835-0s7ok4uw	5411	28	(	(	-LRB-
cord-001835-0s7ok4uw	5411	29	Ni	Ni	NNP
cord-001835-0s7ok4uw	5411	30	-	-	HYPH
cord-001835-0s7ok4uw	5411	31	NTA	NTA	NNP
cord-001835-0s7ok4uw	5411	32	resin	resin	NN
cord-001835-0s7ok4uw	5411	33	)	)	-RRB-
cord-001835-0s7ok4uw	5411	34	.	.	.
cord-001835-0s7ok4uw	5412	1	These	these	DT
cord-001835-0s7ok4uw	5412	2	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	5412	3	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5412	4	have	have	VBP
cord-001835-0s7ok4uw	5412	5	very	very	RB
cord-001835-0s7ok4uw	5412	6	similar	similar	JJ
cord-001835-0s7ok4uw	5412	7	folding	folding	NN
cord-001835-0s7ok4uw	5412	8	type	type	NN
cord-001835-0s7ok4uw	5412	9	structure	structure	NN
cord-001835-0s7ok4uw	5412	10	(	(	-LRB-
cord-001835-0s7ok4uw	5412	11	b	b	NN
cord-001835-0s7ok4uw	5412	12	/	/	SYM
cord-001835-0s7ok4uw	5412	13	a)8	a)8	NN
cord-001835-0s7ok4uw	5412	14	barrel	barrel	NN
cord-001835-0s7ok4uw	5412	15	,	,	,
cord-001835-0s7ok4uw	5412	16	as	as	IN
cord-001835-0s7ok4uw	5412	17	shown	show	VBN
cord-001835-0s7ok4uw	5412	18	in	in	IN
cord-001835-0s7ok4uw	5412	19	crystal	crystal	NN
cord-001835-0s7ok4uw	5412	20	structures	structure	NNS
cord-001835-0s7ok4uw	5412	21	and	and	CC
cord-001835-0s7ok4uw	5412	22	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	5412	23	a	a	DT
cord-001835-0s7ok4uw	5412	24	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	5412	25	peak	peak	NN
cord-001835-0s7ok4uw	5412	26	between	between	IN
cord-001835-0s7ok4uw	5412	27	330	330	CD
cord-001835-0s7ok4uw	5412	28	and	and	CC
cord-001835-0s7ok4uw	5412	29	340	340	CD
cord-001835-0s7ok4uw	5412	30	nm	nm	NN
cord-001835-0s7ok4uw	5412	31	in	in	IN
cord-001835-0s7ok4uw	5412	32	the	the	DT
cord-001835-0s7ok4uw	5412	33	tryptophan	tryptophan	NN
cord-001835-0s7ok4uw	5412	34	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	5412	35	spectra	spectrum	NNS
cord-001835-0s7ok4uw	5412	36	,	,	,
cord-001835-0s7ok4uw	5412	37	indicating	indicate	VBG
cord-001835-0s7ok4uw	5412	38	that	that	IN
cord-001835-0s7ok4uw	5412	39	those	those	DT
cord-001835-0s7ok4uw	5412	40	proteins	protein	NNS
cord-001835-0s7ok4uw	5412	41	are	be	VBP
cord-001835-0s7ok4uw	5412	42	folded	fold	VBN
cord-001835-0s7ok4uw	5412	43	.	.	.
cord-001835-0s7ok4uw	5413	1	Circular	circular	JJ
cord-001835-0s7ok4uw	5413	2	dichroism	dichroism	NN
cord-001835-0s7ok4uw	5413	3	analysis	analysis	NN
cord-001835-0s7ok4uw	5413	4	in	in	IN
cord-001835-0s7ok4uw	5413	5	the	the	DT
cord-001835-0s7ok4uw	5413	6	far	far	JJ
cord-001835-0s7ok4uw	5413	7	-	-	HYPH
cord-001835-0s7ok4uw	5413	8	UV	uv	NN
cord-001835-0s7ok4uw	5413	9	region	region	NN
cord-001835-0s7ok4uw	5413	10	(	(	-LRB-
cord-001835-0s7ok4uw	5413	11	190	190	CD
cord-001835-0s7ok4uw	5413	12	nm	nm	NN
cord-001835-0s7ok4uw	5413	13	to	to	IN
cord-001835-0s7ok4uw	5413	14	240	240	CD
cord-001835-0s7ok4uw	5413	15	nm	nm	NN
cord-001835-0s7ok4uw	5413	16	)	)	-RRB-
cord-001835-0s7ok4uw	5413	17	also	also	RB
cord-001835-0s7ok4uw	5413	18	showed	show	VBD
cord-001835-0s7ok4uw	5413	19	typical	typical	JJ
cord-001835-0s7ok4uw	5413	20	spectra	spectrum	NNS
cord-001835-0s7ok4uw	5413	21	of	of	IN
cord-001835-0s7ok4uw	5413	22	folded	folded	JJ
cord-001835-0s7ok4uw	5413	23	proteins	protein	NNS
cord-001835-0s7ok4uw	5413	24	with	with	IN
cord-001835-0s7ok4uw	5413	25	secondary	secondary	JJ
cord-001835-0s7ok4uw	5413	26	structure	structure	NN
cord-001835-0s7ok4uw	5413	27	composition	composition	NN
cord-001835-0s7ok4uw	5413	28	of	of	IN
cord-001835-0s7ok4uw	5413	29	47	47	CD
cord-001835-0s7ok4uw	5413	30	%	%	NN
cord-001835-0s7ok4uw	5413	31	of	of	IN
cord-001835-0s7ok4uw	5413	32	a	a	DT
cord-001835-0s7ok4uw	5413	33	-	-	HYPH
cord-001835-0s7ok4uw	5413	34	helix	helix	NN
cord-001835-0s7ok4uw	5413	35	and	and	CC
cord-001835-0s7ok4uw	5413	36	13	13	CD
cord-001835-0s7ok4uw	5413	37	%	%	NN
cord-001835-0s7ok4uw	5413	38	of	of	IN
cord-001835-0s7ok4uw	5413	39	b	b	NN
cord-001835-0s7ok4uw	5413	40	-	-	HYPH
cord-001835-0s7ok4uw	5413	41	sheets	sheet	NNS
cord-001835-0s7ok4uw	5413	42	for	for	IN
cord-001835-0s7ok4uw	5413	43	bglA	bgla	NN
cord-001835-0s7ok4uw	5413	44	,	,	,
cord-001835-0s7ok4uw	5413	45	61	61	CD
cord-001835-0s7ok4uw	5413	46	%	%	NN
cord-001835-0s7ok4uw	5413	47	of	of	IN
cord-001835-0s7ok4uw	5413	48	a	a	DT
cord-001835-0s7ok4uw	5413	49	-	-	HYPH
cord-001835-0s7ok4uw	5413	50	helix	helix	NN
cord-001835-0s7ok4uw	5413	51	and	and	CC
cord-001835-0s7ok4uw	5413	52	2.5	2.5	CD
cord-001835-0s7ok4uw	5413	53	%	%	NN
cord-001835-0s7ok4uw	5413	54	of	of	IN
cord-001835-0s7ok4uw	5413	55	b	b	NN
cord-001835-0s7ok4uw	5413	56	-	-	HYPH
cord-001835-0s7ok4uw	5413	57	sheets	sheet	NNS
cord-001835-0s7ok4uw	5413	58	for	for	IN
cord-001835-0s7ok4uw	5413	59	bglB	bglb	CD
cord-001835-0s7ok4uw	5413	60	and	and	CC
cord-001835-0s7ok4uw	5413	61	30	30	CD
cord-001835-0s7ok4uw	5413	62	%	%	NN
cord-001835-0s7ok4uw	5413	63	of	of	IN
cord-001835-0s7ok4uw	5413	64	a	a	DT
cord-001835-0s7ok4uw	5413	65	-	-	HYPH
cord-001835-0s7ok4uw	5413	66	helix	helix	NN
cord-001835-0s7ok4uw	5413	67	and	and	CC
cord-001835-0s7ok4uw	5413	68	20	20	CD
cord-001835-0s7ok4uw	5413	69	%	%	NN
cord-001835-0s7ok4uw	5413	70	of	of	IN
cord-001835-0s7ok4uw	5413	71	b	b	NN
cord-001835-0s7ok4uw	5413	72	-	-	HYPH
cord-001835-0s7ok4uw	5413	73	sheets	sheet	NNS
cord-001835-0s7ok4uw	5413	74	for	for	IN
cord-001835-0s7ok4uw	5413	75	bglThm	bglThm	NNS
cord-001835-0s7ok4uw	5413	76	.	.	.
cord-001835-0s7ok4uw	5414	1	The	the	DT
cord-001835-0s7ok4uw	5414	2	average	average	JJ
cord-001835-0s7ok4uw	5414	3	degree	degree	NN
cord-001835-0s7ok4uw	5414	4	of	of	IN
cord-001835-0s7ok4uw	5414	5	accessibility	accessibility	NN
cord-001835-0s7ok4uw	5414	6	to	to	IN
cord-001835-0s7ok4uw	5414	7	the	the	DT
cord-001835-0s7ok4uw	5414	8	exposed	expose	VBN
cord-001835-0s7ok4uw	5414	9	tryptophan	tryptophan	NN
cord-001835-0s7ok4uw	5414	10	residues	residue	NNS
cord-001835-0s7ok4uw	5414	11	in	in	IN
cord-001835-0s7ok4uw	5414	12	the	the	DT
cord-001835-0s7ok4uw	5414	13	native	native	JJ
cord-001835-0s7ok4uw	5414	14	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5414	15	to	to	IN
cord-001835-0s7ok4uw	5414	16	increasing	increase	VBG
cord-001835-0s7ok4uw	5414	17	concentrations	concentration	NNS
cord-001835-0s7ok4uw	5414	18	of	of	IN
cord-001835-0s7ok4uw	5414	19	the	the	DT
cord-001835-0s7ok4uw	5414	20	acrylamide	acrylamide	NN
cord-001835-0s7ok4uw	5414	21	suppressor	suppressor	NN
cord-001835-0s7ok4uw	5414	22	(	(	-LRB-
cord-001835-0s7ok4uw	5414	23	Stern	Stern	NNP
cord-001835-0s7ok4uw	5414	24	-	-	HYPH
cord-001835-0s7ok4uw	5414	25	Volmer	Volmer	NNP
cord-001835-0s7ok4uw	5414	26	constant	constant	NN
cord-001835-0s7ok4uw	5414	27	-KSV	-ksv	NN
cord-001835-0s7ok4uw	5414	28	)	)	-RRB-
cord-001835-0s7ok4uw	5414	29	is	be	VBZ
cord-001835-0s7ok4uw	5414	30	greater	great	JJR
cord-001835-0s7ok4uw	5414	31	to	to	IN
cord-001835-0s7ok4uw	5414	32	bglA	bglA	NNP
cord-001835-0s7ok4uw	5414	33	(	(	-LRB-
cord-001835-0s7ok4uw	5414	34	9.49	9.49	CD
cord-001835-0s7ok4uw	5414	35	)	)	-RRB-
cord-001835-0s7ok4uw	5414	36	,	,	,
cord-001835-0s7ok4uw	5414	37	but	but	CC
cord-001835-0s7ok4uw	5414	38	similar	similar	JJ
cord-001835-0s7ok4uw	5414	39	to	to	IN
cord-001835-0s7ok4uw	5414	40	bglB	bglb	CD
cord-001835-0s7ok4uw	5414	41	(	(	-LRB-
cord-001835-0s7ok4uw	5414	42	3.17	3.17	CD
cord-001835-0s7ok4uw	5414	43	)	)	-RRB-
cord-001835-0s7ok4uw	5414	44	and	and	CC
cord-001835-0s7ok4uw	5414	45	bglThm	bglThm	NNS
cord-001835-0s7ok4uw	5414	46	(	(	-LRB-
cord-001835-0s7ok4uw	5414	47	3.84	3.84	CD
cord-001835-0s7ok4uw	5414	48	)	)	-RRB-
cord-001835-0s7ok4uw	5414	49	.	.	.
cord-001835-0s7ok4uw	5415	1	The	the	DT
cord-001835-0s7ok4uw	5415	2	thermal	thermal	JJ
cord-001835-0s7ok4uw	5415	3	stability	stability	NN
cord-001835-0s7ok4uw	5415	4	determined	determine	VBN
cord-001835-0s7ok4uw	5415	5	by	by	IN
cord-001835-0s7ok4uw	5415	6	DSF	DSF	NNP
cord-001835-0s7ok4uw	5415	7	was	be	VBD
cord-001835-0s7ok4uw	5415	8	higher	high	JJR
cord-001835-0s7ok4uw	5415	9	for	for	IN
cord-001835-0s7ok4uw	5415	10	bglB	bglb	CD
cord-001835-0s7ok4uw	5416	1	(	(	-LRB-
cord-001835-0s7ok4uw	5416	2	Tm	Tm	NNP
cord-001835-0s7ok4uw	5416	3	43.8	43.8	CD
cord-001835-0s7ok4uw	5416	4	C	C	NNP
cord-001835-0s7ok4uw	5416	5	)	)	-RRB-
cord-001835-0s7ok4uw	5417	1	than	than	IN
cord-001835-0s7ok4uw	5417	2	for	for	IN
cord-001835-0s7ok4uw	5417	3	bglA	bglA	NNP
cord-001835-0s7ok4uw	5418	1	(	(	-LRB-
cord-001835-0s7ok4uw	5418	2	Tm	Tm	NNP
cord-001835-0s7ok4uw	5418	3	35	35	CD
cord-001835-0s7ok4uw	5418	4	.	.	.
cord-001835-0s7ok4uw	5419	1	2	2	CD
cord-001835-0s7ok4uw	5419	2	C	C	NNP
cord-001835-0s7ok4uw	5419	3	)	)	-RRB-
cord-001835-0s7ok4uw	5419	4	.	.	.
cord-001835-0s7ok4uw	5420	1	The	the	DT
cord-001835-0s7ok4uw	5420	2	bglThm	bglThm	NNS
cord-001835-0s7ok4uw	5420	3	was	be	VBD
cord-001835-0s7ok4uw	5420	4	stable	stable	JJ
cord-001835-0s7ok4uw	5420	5	at	at	IN
cord-001835-0s7ok4uw	5420	6	478C	478c	CD
cord-001835-0s7ok4uw	5420	7	and	and	CC
cord-001835-0s7ok4uw	5420	8	remained	remain	VBD
cord-001835-0s7ok4uw	5420	9	stable	stable	JJ
cord-001835-0s7ok4uw	5420	10	for	for	IN
cord-001835-0s7ok4uw	5420	11	up	up	IN
cord-001835-0s7ok4uw	5420	12	to	to	TO
cord-001835-0s7ok4uw	5420	13	4	4	CD
cord-001835-0s7ok4uw	5420	14	h	h	NN
cord-001835-0s7ok4uw	5420	15	at	at	IN
cord-001835-0s7ok4uw	5420	16	808C.	808c.	NN
cord-001835-0s7ok4uw	5421	1	In	in	IN
cord-001835-0s7ok4uw	5421	2	addition	addition	NN
cord-001835-0s7ok4uw	5421	3	the	the	DT
cord-001835-0s7ok4uw	5421	4	thermal	thermal	JJ
cord-001835-0s7ok4uw	5421	5	inactivation	inactivation	NN
cord-001835-0s7ok4uw	5421	6	kinetics	kinetics	NN
cord-001835-0s7ok4uw	5421	7	at	at	IN
cord-001835-0s7ok4uw	5421	8	478C	478c	CD
cord-001835-0s7ok4uw	5421	9	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	5421	10	by	by	IN
cord-001835-0s7ok4uw	5421	11	the	the	DT
cord-001835-0s7ok4uw	5421	12	relative	relative	JJ
cord-001835-0s7ok4uw	5421	13	remaining	remain	VBG
cord-001835-0s7ok4uw	5421	14	activity	activity	NN
cord-001835-0s7ok4uw	5421	15	showed	show	VBD
cord-001835-0s7ok4uw	5421	16	that	that	IN
cord-001835-0s7ok4uw	5421	17	bglA	bglA	NNP
cord-001835-0s7ok4uw	5421	18	denaturation	denaturation	NN
cord-001835-0s7ok4uw	5421	19	(	(	-LRB-
cord-001835-0s7ok4uw	5421	20	kinactivation	kinactivation	NN
cord-001835-0s7ok4uw	5421	21	of	of	IN
cord-001835-0s7ok4uw	5421	22	1.9	1.9	CD
cord-001835-0s7ok4uw	5421	23	s-1	s-1	NN
cord-001835-0s7ok4uw	5421	24	)	)	-RRB-
cord-001835-0s7ok4uw	5421	25	is	be	VBZ
cord-001835-0s7ok4uw	5421	26	faster	fast	JJR
cord-001835-0s7ok4uw	5421	27	than	than	IN
cord-001835-0s7ok4uw	5421	28	bglB	bglb	CD
cord-001835-0s7ok4uw	5422	1	(	(	-LRB-
cord-001835-0s7ok4uw	5422	2	kinactivation	kinactivation	NN
cord-001835-0s7ok4uw	5422	3	of	of	IN
cord-001835-0s7ok4uw	5422	4	31.3	31.3	CD
cord-001835-0s7ok4uw	5422	5	s-1	s-1	NN
cord-001835-0s7ok4uw	5422	6	)	)	-RRB-
cord-001835-0s7ok4uw	5422	7	.	.	.
cord-001835-0s7ok4uw	5423	1	On	on	IN
cord-001835-0s7ok4uw	5423	2	the	the	DT
cord-001835-0s7ok4uw	5423	3	other	other	JJ
cord-001835-0s7ok4uw	5423	4	site	site	NN
cord-001835-0s7ok4uw	5423	5	,	,	,
cord-001835-0s7ok4uw	5423	6	bglThm	bglthm	NN
cord-001835-0s7ok4uw	5423	7	inactivation	inactivation	NN
cord-001835-0s7ok4uw	5423	8	at	at	IN
cord-001835-0s7ok4uw	5423	9	958C	958c	CD
cord-001835-0s7ok4uw	5423	10	was	be	VBD
cord-001835-0s7ok4uw	5423	11	a	a	DT
cord-001835-0s7ok4uw	5423	12	two	two	CD
cord-001835-0s7ok4uw	5423	13	-	-	HYPH
cord-001835-0s7ok4uw	5423	14	step	step	NN
cord-001835-0s7ok4uw	5423	15	process	process	NN
cord-001835-0s7ok4uw	5423	16	,	,	,
cord-001835-0s7ok4uw	5423	17	which	which	WDT
cord-001835-0s7ok4uw	5423	18	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	5423	19	an	an	DT
cord-001835-0s7ok4uw	5423	20	initial	initial	JJ
cord-001835-0s7ok4uw	5423	21	fast	fast	JJ
cord-001835-0s7ok4uw	5423	22	step	step	NN
cord-001835-0s7ok4uw	5423	23	(	(	-LRB-
cord-001835-0s7ok4uw	5423	24	kinactivation	kinactivation	NN
cord-001835-0s7ok4uw	5423	25	of	of	IN
cord-001835-0s7ok4uw	5423	26	2.9	2.9	CD
cord-001835-0s7ok4uw	5423	27	s	s	POS
cord-001835-0s7ok4uw	5423	28	21	21	CD
cord-001835-0s7ok4uw	5423	29	)	)	-RRB-
cord-001835-0s7ok4uw	5423	30	followed	follow	VBN
cord-001835-0s7ok4uw	5423	31	by	by	IN
cord-001835-0s7ok4uw	5423	32	a	a	DT
cord-001835-0s7ok4uw	5423	33	slow	slow	JJ
cord-001835-0s7ok4uw	5423	34	step	step	NN
cord-001835-0s7ok4uw	5423	35	(	(	-LRB-
cord-001835-0s7ok4uw	5423	36	kinactivation	kinactivation	NN
cord-001835-0s7ok4uw	5423	37	of	of	IN
cord-001835-0s7ok4uw	5423	38	0.2	0.2	CD
cord-001835-0s7ok4uw	5423	39	s-1	s-1	NN
cord-001835-0s7ok4uw	5423	40	)	)	-RRB-
cord-001835-0s7ok4uw	5423	41	.	.	.
cord-001835-0s7ok4uw	5424	1	The	the	DT
cord-001835-0s7ok4uw	5424	2	chemical	chemical	JJ
cord-001835-0s7ok4uw	5424	3	denaturation	denaturation	NN
cord-001835-0s7ok4uw	5424	4	by	by	IN
cord-001835-0s7ok4uw	5424	5	urea	urea	NN
cord-001835-0s7ok4uw	5424	6	followed	follow	VBD
cord-001835-0s7ok4uw	5424	7	using	use	VBG
cord-001835-0s7ok4uw	5424	8	tryptophan	tryptophan	NN
cord-001835-0s7ok4uw	5424	9	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	5424	10	showed	show	VBD
cord-001835-0s7ok4uw	5424	11	a	a	DT
cord-001835-0s7ok4uw	5424	12	transition	transition	NN
cord-001835-0s7ok4uw	5425	1	PL-039	PL-039	NNP
cord-001835-0s7ok4uw	5425	2	Covalent	Covalent	NNP
cord-001835-0s7ok4uw	5425	3	structure	structure	NN
cord-001835-0s7ok4uw	5425	4	of	of	IN
cord-001835-0s7ok4uw	5425	5	single	single	RB
cord-001835-0s7ok4uw	5425	6	-	-	HYPH
cord-001835-0s7ok4uw	5425	7	stranded	strand	VBN
cord-001835-0s7ok4uw	5425	8	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	5425	9	and	and	CC
cord-001835-0s7ok4uw	5425	10	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5425	11	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	5425	12	cross	cross	VBP
cord-001835-0s7ok4uw	5425	13	-	-	VBN
cord-001835-0s7ok4uw	5425	14	linked	link	VBN
cord-001835-0s7ok4uw	5425	15	by	by	IN
cord-001835-0s7ok4uw	5425	16	fxiiia	fxiiia	NN
cord-001835-0s7ok4uw	5425	17	.	.	.
cord-001835-0s7ok4uw	5426	1	The	the	DT
cord-001835-0s7ok4uw	5426	2	influence	influence	NN
cord-001835-0s7ok4uw	5426	3	of	of	IN
cord-001835-0s7ok4uw	5426	4	free	free	JJ
cord-001835-0s7ok4uw	5426	5	radical	radical	JJ
cord-001835-0s7ok4uw	5426	6	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5426	7	Anna	Anna	NNP
cord-001835-0s7ok4uw	5426	8	Bychkova	Bychkova	NNP
cord-001835-0s7ok4uw	5426	9	1	1	CD
cord-001835-0s7ok4uw	5426	10	,	,	,
cord-001835-0s7ok4uw	5426	11	Vera	Vera	NNP
cord-001835-0s7ok4uw	5426	12	Leonova	Leonova	NNP
cord-001835-0s7ok4uw	5426	13	1	1	CD
cord-001835-0s7ok4uw	5426	14	,	,	,
cord-001835-0s7ok4uw	5426	15	Alexander	Alexander	NNP
cord-001835-0s7ok4uw	5426	16	Shchegolikhin	Shchegolikhin	NNP
cord-001835-0s7ok4uw	5426	17	1	1	CD
cord-001835-0s7ok4uw	5426	18	,	,	,
cord-001835-0s7ok4uw	5426	19	Marina	Marina	NNP
cord-001835-0s7ok4uw	5426	20	Biryukova	Biryukova	NNP
cord-001835-0s7ok4uw	5426	21	1	1	CD
cord-001835-0s7ok4uw	5426	22	,	,	,
cord-001835-0s7ok4uw	5426	23	Elizaveta	Elizaveta	NNP
cord-001835-0s7ok4uw	5426	24	Kostanova	Kostanova	NNP
cord-001835-0s7ok4uw	5426	25	1	1	CD
cord-001835-0s7ok4uw	5426	26	,	,	,
cord-001835-0s7ok4uw	5426	27	Mark	Mark	NNP
cord-001835-0s7ok4uw	5426	28	Rosenfeld	Rosenfeld	NNP
cord-001835-0s7ok4uw	5426	29	1	1	CD
cord-001835-0s7ok4uw	5426	30	1	1	CD
cord-001835-0s7ok4uw	5426	31	N.	N.	NNP
cord-001835-0s7ok4uw	5426	32	M.	M.	NNP
cord-001835-0s7ok4uw	5426	33	Emanuel	Emanuel	NNP
cord-001835-0s7ok4uw	5426	34	Institute	Institute	NNP
cord-001835-0s7ok4uw	5426	35	Of	of	IN
cord-001835-0s7ok4uw	5426	36	Biochemical	Biochemical	NNP
cord-001835-0s7ok4uw	5426	37	Physics	Physics	NNP
cord-001835-0s7ok4uw	5426	38	,	,	,
cord-001835-0s7ok4uw	5426	39	Russian	Russian	NNP
cord-001835-0s7ok4uw	5426	40	Academy	Academy	NNP
cord-001835-0s7ok4uw	5426	41	Of	of	IN
cord-001835-0s7ok4uw	5426	42	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	5426	43	Protein	Protein	NNP
cord-001835-0s7ok4uw	5426	44	structure	structure	NN
cord-001835-0s7ok4uw	5426	45	and	and	CC
cord-001835-0s7ok4uw	5426	46	function	function	VB
cord-001835-0s7ok4uw	5426	47	Native	native	JJ
cord-001835-0s7ok4uw	5426	48	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	5426	49	is	be	VBZ
cord-001835-0s7ok4uw	5426	50	a	a	DT
cord-001835-0s7ok4uw	5426	51	key	key	JJ
cord-001835-0s7ok4uw	5426	52	blood	blood	NN
cord-001835-0s7ok4uw	5426	53	plasma	plasma	NN
cord-001835-0s7ok4uw	5426	54	protein	protein	NN
cord-001835-0s7ok4uw	5426	55	whose	whose	WP$
cord-001835-0s7ok4uw	5426	56	main	main	JJ
cord-001835-0s7ok4uw	5426	57	function	function	NN
cord-001835-0s7ok4uw	5426	58	is	be	VBZ
cord-001835-0s7ok4uw	5426	59	to	to	TO
cord-001835-0s7ok4uw	5426	60	maintain	maintain	VB
cord-001835-0s7ok4uw	5426	61	hemostasis	hemostasis	NN
cord-001835-0s7ok4uw	5426	62	by	by	IN
cord-001835-0s7ok4uw	5426	63	virtue	virtue	NN
cord-001835-0s7ok4uw	5426	64	of	of	IN
cord-001835-0s7ok4uw	5426	65	producing	produce	VBG
cord-001835-0s7ok4uw	5426	66	the	the	DT
cord-001835-0s7ok4uw	5426	67	cross	cross	NN
cord-001835-0s7ok4uw	5426	68	-	-	JJ
cord-001835-0s7ok4uw	5426	69	linked	link	VBN
cord-001835-0s7ok4uw	5426	70	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5426	71	clots	clot	NNS
cord-001835-0s7ok4uw	5426	72	under	under	IN
cord-001835-0s7ok4uw	5426	73	the	the	DT
cord-001835-0s7ok4uw	5426	74	effect	effect	NN
cord-001835-0s7ok4uw	5426	75	of	of	IN
cord-001835-0s7ok4uw	5426	76	thrombin	thrombin	NN
cord-001835-0s7ok4uw	5426	77	and	and	CC
cord-001835-0s7ok4uw	5426	78	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5426	79	-	-	HYPH
cord-001835-0s7ok4uw	5426	80	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	5426	81	factor	factor	NN
cord-001835-0s7ok4uw	5426	82	(	(	-LRB-
cord-001835-0s7ok4uw	5426	83	FXIIIa	FXIIIa	NNS
cord-001835-0s7ok4uw	5426	84	)	)	-RRB-
cord-001835-0s7ok4uw	5426	85	.	.	.
cord-001835-0s7ok4uw	5427	1	FXIIIa	FXIIIa	NNS
cord-001835-0s7ok4uw	5427	2	-	-	HYPH
cord-001835-0s7ok4uw	5427	3	mediated	mediate	VBN
cord-001835-0s7ok4uw	5427	4	isopeptide	isopeptide	NNP
cord-001835-0s7ok4uw	5427	5	g	g	NN
cord-001835-0s7ok4uw	5427	6	-	-	HYPH
cord-001835-0s7ok4uw	5427	7	g	g	NNP
cord-001835-0s7ok4uw	5427	8	bonds	bond	NNS
cord-001835-0s7ok4uw	5427	9	are	be	VBP
cord-001835-0s7ok4uw	5427	10	known	know	VBN
cord-001835-0s7ok4uw	5427	11	to	to	TO
cord-001835-0s7ok4uw	5427	12	be	be	VB
cord-001835-0s7ok4uw	5427	13	produced	produce	VBN
cord-001835-0s7ok4uw	5427	14	between	between	IN
cord-001835-0s7ok4uw	5427	15	g	g	NN
cord-001835-0s7ok4uw	5427	16	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	5427	17	chains	chain	NNS
cord-001835-0s7ok4uw	5427	18	of	of	IN
cord-001835-0s7ok4uw	5427	19	adjacent	adjacent	JJ
cord-001835-0s7ok4uw	5427	20	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	5427	21	or	or	CC
cord-001835-0s7ok4uw	5427	22	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5427	23	molecules	molecule	NNS
cord-001835-0s7ok4uw	5427	24	.	.	.
cord-001835-0s7ok4uw	5428	1	But	but	CC
cord-001835-0s7ok4uw	5428	2	there	there	EX
cord-001835-0s7ok4uw	5428	3	are	be	VBP
cord-001835-0s7ok4uw	5428	4	apparently	apparently	RB
cord-001835-0s7ok4uw	5428	5	conflicting	conflict	VBG
cord-001835-0s7ok4uw	5428	6	ideas	idea	NNS
cord-001835-0s7ok4uw	5428	7	regarding	regard	VBG
cord-001835-0s7ok4uw	5428	8	the	the	DT
cord-001835-0s7ok4uw	5428	9	orientation	orientation	NN
cord-001835-0s7ok4uw	5428	10	of	of	IN
cord-001835-0s7ok4uw	5428	11	g	g	NN
cord-001835-0s7ok4uw	5428	12	-	-	HYPH
cord-001835-0s7ok4uw	5428	13	g	g	NNP
cord-001835-0s7ok4uw	5428	14	bonds	bond	NNS
cord-001835-0s7ok4uw	5428	15	.	.	.
cord-001835-0s7ok4uw	5429	1	In	in	IN
cord-001835-0s7ok4uw	5429	2	this	this	DT
cord-001835-0s7ok4uw	5429	3	study	study	NN
cord-001835-0s7ok4uw	5429	4	several	several	JJ
cord-001835-0s7ok4uw	5429	5	peculiarities	peculiarity	NNS
cord-001835-0s7ok4uw	5429	6	of	of	IN
cord-001835-0s7ok4uw	5429	7	self	self	NN
cord-001835-0s7ok4uw	5429	8	-	-	HYPH
cord-001835-0s7ok4uw	5429	9	assembly	assembly	NN
cord-001835-0s7ok4uw	5429	10	of	of	IN
cord-001835-0s7ok4uw	5429	11	fibrin(ogen	fibrin(ogen	NNP
cord-001835-0s7ok4uw	5429	12	)	)	-RRB-
cord-001835-0s7ok4uw	5429	13	and	and	CC
cord-001835-0s7ok4uw	5429	14	induced	induce	VBN
cord-001835-0s7ok4uw	5429	15	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5429	16	of	of	IN
cord-001835-0s7ok4uw	5429	17	the	the	DT
cord-001835-0s7ok4uw	5429	18	proteins	protein	NNS
cord-001835-0s7ok4uw	5429	19	have	have	VBP
cord-001835-0s7ok4uw	5429	20	been	be	VBN
cord-001835-0s7ok4uw	5429	21	studied	study	VBN
cord-001835-0s7ok4uw	5429	22	with	with	IN
cord-001835-0s7ok4uw	5429	23	the	the	DT
cord-001835-0s7ok4uw	5429	24	aid	aid	NN
cord-001835-0s7ok4uw	5429	25	of	of	IN
cord-001835-0s7ok4uw	5429	26	elastic	elastic	JJ
cord-001835-0s7ok4uw	5429	27	and	and	CC
cord-001835-0s7ok4uw	5429	28	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	5429	29	light	light	JJ
cord-001835-0s7ok4uw	5429	30	scattering	scattering	NN
cord-001835-0s7ok4uw	5429	31	,	,	,
cord-001835-0s7ok4uw	5429	32	UV-	UV-	NNP
cord-001835-0s7ok4uw	5429	33	,	,	,
cord-001835-0s7ok4uw	5429	34	FTIR	FTIR	NNP
cord-001835-0s7ok4uw	5429	35	-	-	:
cord-001835-0s7ok4uw	5429	36	and	and	CC
cord-001835-0s7ok4uw	5429	37	Raman	Raman	NNP
cord-001835-0s7ok4uw	5429	38	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	5429	39	methods	method	NNS
cord-001835-0s7ok4uw	5429	40	.	.	.
cord-001835-0s7ok4uw	5430	1	In	in	IN
cord-001835-0s7ok4uw	5430	2	the	the	DT
cord-001835-0s7ok4uw	5430	3	presence	presence	NN
cord-001835-0s7ok4uw	5430	4	of	of	IN
cord-001835-0s7ok4uw	5430	5	FXIIIa	FXIIIa	NNS
cord-001835-0s7ok4uw	5430	6	both	both	CC
cord-001835-0s7ok4uw	5430	7	the	the	DT
cord-001835-0s7ok4uw	5430	8	non	non	JJ
cord-001835-0s7ok4uw	5430	9	-	-	JJ
cord-001835-0s7ok4uw	5430	10	oxidized	oxidized	JJ
cord-001835-0s7ok4uw	5430	11	and	and	CC
cord-001835-0s7ok4uw	5430	12	oxidized	oxidized	JJ
cord-001835-0s7ok4uw	5430	13	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	5430	14	molecules	molecule	NNS
cord-001835-0s7ok4uw	5430	15	has	have	VBZ
cord-001835-0s7ok4uw	5430	16	been	be	VBN
cord-001835-0s7ok4uw	5430	17	shown	show	VBN
cord-001835-0s7ok4uw	5430	18	to	to	TO
cord-001835-0s7ok4uw	5430	19	bind	bind	VB
cord-001835-0s7ok4uw	5430	20	to	to	IN
cord-001835-0s7ok4uw	5430	21	each	each	DT
cord-001835-0s7ok4uw	5430	22	other	other	JJ
cord-001835-0s7ok4uw	5430	23	in	in	IN
cord-001835-0s7ok4uw	5430	24	the	the	DT
cord-001835-0s7ok4uw	5430	25	"	"	``
cord-001835-0s7ok4uw	5430	26	endto	endto	NN
cord-001835-0s7ok4uw	5430	27	-	-	HYPH
cord-001835-0s7ok4uw	5430	28	end	end	NN
cord-001835-0s7ok4uw	5430	29	"	"	''
cord-001835-0s7ok4uw	5430	30	fashion	fashion	NN
cord-001835-0s7ok4uw	5430	31	to	to	TO
cord-001835-0s7ok4uw	5430	32	form	form	VB
cord-001835-0s7ok4uw	5430	33	the	the	DT
cord-001835-0s7ok4uw	5430	34	flexible	flexible	JJ
cord-001835-0s7ok4uw	5430	35	covalently	covalently	RB
cord-001835-0s7ok4uw	5430	36	cross	cross	JJ
cord-001835-0s7ok4uw	5430	37	-	-	JJ
cord-001835-0s7ok4uw	5430	38	linked	link	VBN
cord-001835-0s7ok4uw	5430	39	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	5430	40	homopolymers	homopolymer	NNS
cord-001835-0s7ok4uw	5430	41	.	.	.
cord-001835-0s7ok4uw	5431	1	To	to	TO
cord-001835-0s7ok4uw	5431	2	identify	identify	VB
cord-001835-0s7ok4uw	5431	3	the	the	DT
cord-001835-0s7ok4uw	5431	4	orientation	orientation	NN
cord-001835-0s7ok4uw	5431	5	of	of	IN
cord-001835-0s7ok4uw	5431	6	g	g	NN
cord-001835-0s7ok4uw	5431	7	-	-	HYPH
cord-001835-0s7ok4uw	5431	8	g	g	NNP
cord-001835-0s7ok4uw	5431	9	bonds	bond	NNS
cord-001835-0s7ok4uw	5431	10	in	in	IN
cord-001835-0s7ok4uw	5431	11	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5431	12	protofibrils	protofibril	NNS
cord-001835-0s7ok4uw	5431	13	a	a	DT
cord-001835-0s7ok4uw	5431	14	novel	novel	JJ
cord-001835-0s7ok4uw	5431	15	approach	approach	NN
cord-001835-0s7ok4uw	5431	16	based	base	VBN
cord-001835-0s7ok4uw	5431	17	on	on	IN
cord-001835-0s7ok4uw	5431	18	self	self	NN
cord-001835-0s7ok4uw	5431	19	-	-	HYPH
cord-001835-0s7ok4uw	5431	20	assembly	assembly	NN
cord-001835-0s7ok4uw	5431	21	of	of	IN
cord-001835-0s7ok4uw	5431	22	soluble	soluble	JJ
cord-001835-0s7ok4uw	5431	23	cross	cross	JJ
cord-001835-0s7ok4uw	5431	24	-	-	JJ
cord-001835-0s7ok4uw	5431	25	linked	link	VBN
cord-001835-0s7ok4uw	5431	26	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5431	27	protofibrils	protofibril	NNS
cord-001835-0s7ok4uw	5431	28	and	and	CC
cord-001835-0s7ok4uw	5431	29	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5431	30	dissociation	dissociation	NN
cord-001835-0s7ok4uw	5431	31	in	in	IN
cord-001835-0s7ok4uw	5431	32	the	the	DT
cord-001835-0s7ok4uw	5431	33	urea	urea	NN
cord-001835-0s7ok4uw	5431	34	solution	solution	NN
cord-001835-0s7ok4uw	5431	35	of	of	IN
cord-001835-0s7ok4uw	5431	36	moderate	moderate	JJ
cord-001835-0s7ok4uw	5431	37	concentrations	concentration	NNS
cord-001835-0s7ok4uw	5431	38	has	have	VBZ
cord-001835-0s7ok4uw	5431	39	been	be	VBN
cord-001835-0s7ok4uw	5431	40	applied	apply	VBN
cord-001835-0s7ok4uw	5431	41	.	.	.
cord-001835-0s7ok4uw	5432	1	The	the	DT
cord-001835-0s7ok4uw	5432	2	results	result	NNS
cord-001835-0s7ok4uw	5432	3	of	of	IN
cord-001835-0s7ok4uw	5432	4	elastic	elastic	JJ
cord-001835-0s7ok4uw	5432	5	and	and	CC
cord-001835-0s7ok4uw	5432	6	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	5432	7	light	light	JJ
cord-001835-0s7ok4uw	5432	8	scattering	scattering	NN
cord-001835-0s7ok4uw	5432	9	coupled	couple	VBN
cord-001835-0s7ok4uw	5432	10	with	with	IN
cord-001835-0s7ok4uw	5432	11	analytical	analytical	JJ
cord-001835-0s7ok4uw	5432	12	ultracentrifugation	ultracentrifugation	NN
cord-001835-0s7ok4uw	5432	13	indicated	indicate	VBD
cord-001835-0s7ok4uw	5432	14	the	the	DT
cord-001835-0s7ok4uw	5432	15	protofibrils	protofibril	NNS
cord-001835-0s7ok4uw	5432	16	to	to	TO
cord-001835-0s7ok4uw	5432	17	exhibit	exhibit	VB
cord-001835-0s7ok4uw	5432	18	an	an	DT
cord-001835-0s7ok4uw	5432	19	ability	ability	NN
cord-001835-0s7ok4uw	5432	20	to	to	TO
cord-001835-0s7ok4uw	5432	21	dissociate	dissociate	VB
cord-001835-0s7ok4uw	5432	22	under	under	IN
cord-001835-0s7ok4uw	5432	23	increasing	increase	VBG
cord-001835-0s7ok4uw	5432	24	urea	urea	NN
cord-001835-0s7ok4uw	5432	25	concentration	concentration	NN
cord-001835-0s7ok4uw	5432	26	to	to	TO
cord-001835-0s7ok4uw	5432	27	yield	yield	VB
cord-001835-0s7ok4uw	5432	28	single	single	RB
cord-001835-0s7ok4uw	5432	29	-	-	HYPH
cord-001835-0s7ok4uw	5432	30	stranded	strand	VBN
cord-001835-0s7ok4uw	5432	31	structures	structure	NNS
cord-001835-0s7ok4uw	5432	32	entirely	entirely	RB
cord-001835-0s7ok4uw	5432	33	brought	bring	VBD
cord-001835-0s7ok4uw	5432	34	about	about	RP
cord-001835-0s7ok4uw	5432	35	by	by	IN
cord-001835-0s7ok4uw	5432	36	g	g	NN
cord-001835-0s7ok4uw	5432	37	-	-	HYPH
cord-001835-0s7ok4uw	5432	38	g	g	NNP
cord-001835-0s7ok4uw	5432	39	bonds	bond	NNS
cord-001835-0s7ok4uw	5432	40	.	.	.
cord-001835-0s7ok4uw	5433	1	The	the	DT
cord-001835-0s7ok4uw	5433	2	results	result	NNS
cord-001835-0s7ok4uw	5433	3	of	of	IN
cord-001835-0s7ok4uw	5433	4	this	this	DT
cord-001835-0s7ok4uw	5433	5	study	study	NN
cord-001835-0s7ok4uw	5433	6	provide	provide	VBP
cord-001835-0s7ok4uw	5433	7	an	an	DT
cord-001835-0s7ok4uw	5433	8	evidence	evidence	NN
cord-001835-0s7ok4uw	5433	9	to	to	TO
cord-001835-0s7ok4uw	5433	10	support	support	VB
cord-001835-0s7ok4uw	5433	11	the	the	DT
cord-001835-0s7ok4uw	5433	12	model	model	NN
cord-001835-0s7ok4uw	5433	13	of	of	IN
cord-001835-0s7ok4uw	5433	14	the	the	DT
cord-001835-0s7ok4uw	5433	15	longitudinal	longitudinal	JJ
cord-001835-0s7ok4uw	5433	16	g	g	NN
cord-001835-0s7ok4uw	5433	17	-	-	HYPH
cord-001835-0s7ok4uw	5433	18	g	g	NN
cord-001835-0s7ok4uw	5433	19	bonds	bond	NNS
cord-001835-0s7ok4uw	5433	20	that	that	WDT
cord-001835-0s7ok4uw	5433	21	form	form	VBP
cord-001835-0s7ok4uw	5433	22	between	between	IN
cord-001835-0s7ok4uw	5433	23	the	the	DT
cord-001835-0s7ok4uw	5433	24	g	g	NN
cord-001835-0s7ok4uw	5433	25	chains	chain	NNS
cord-001835-0s7ok4uw	5433	26	end	end	VB
cord-001835-0s7ok4uw	5433	27	-	-	HYPH
cord-001835-0s7ok4uw	5433	28	to	to	IN
cord-001835-0s7ok4uw	5433	29	-	-	HYPH
cord-001835-0s7ok4uw	5433	30	end	end	NN
cord-001835-0s7ok4uw	5433	31	within	within	IN
cord-001835-0s7ok4uw	5433	32	the	the	DT
cord-001835-0s7ok4uw	5433	33	same	same	JJ
cord-001835-0s7ok4uw	5433	34	strand	strand	NN
cord-001835-0s7ok4uw	5433	35	of	of	IN
cord-001835-0s7ok4uw	5433	36	a	a	DT
cord-001835-0s7ok4uw	5433	37	protofibril	protofibril	NN
cord-001835-0s7ok4uw	5433	38	.	.	.
cord-001835-0s7ok4uw	5434	1	Since	since	IN
cord-001835-0s7ok4uw	5434	2	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	5434	3	is	be	VBZ
cord-001835-0s7ok4uw	5434	4	known	know	VBN
cord-001835-0s7ok4uw	5434	5	to	to	TO
cord-001835-0s7ok4uw	5434	6	be	be	VB
cord-001835-0s7ok4uw	5434	7	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	5434	8	to	to	IN
cord-001835-0s7ok4uw	5434	9	ROS	ROS	NNP
cord-001835-0s7ok4uw	5434	10	the	the	DT
cord-001835-0s7ok4uw	5434	11	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	5434	12	of	of	IN
cord-001835-0s7ok4uw	5434	13	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	5434	14	and	and	CC
cord-001835-0s7ok4uw	5434	15	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5434	16	self	self	NN
cord-001835-0s7ok4uw	5434	17	-	-	HYPH
cord-001835-0s7ok4uw	5434	18	assembly	assembly	NN
cord-001835-0s7ok4uw	5434	19	under	under	IN
cord-001835-0s7ok4uw	5434	20	induced	induce	VBN
cord-001835-0s7ok4uw	5434	21	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5434	22	have	have	VBP
cord-001835-0s7ok4uw	5434	23	been	be	VBN
cord-001835-0s7ok4uw	5434	24	investigated	investigate	VBN
cord-001835-0s7ok4uw	5434	25	.	.	.
cord-001835-0s7ok4uw	5435	1	In	in	IN
cord-001835-0s7ok4uw	5435	2	both	both	DT
cord-001835-0s7ok4uw	5435	3	cases	case	NNS
cord-001835-0s7ok4uw	5435	4	the	the	DT
cord-001835-0s7ok4uw	5435	5	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	5435	6	chains	chain	NNS
cord-001835-0s7ok4uw	5435	7	of	of	IN
cord-001835-0s7ok4uw	5435	8	the	the	DT
cord-001835-0s7ok4uw	5435	9	oxidized	oxidize	VBN
cord-001835-0s7ok4uw	5435	10	fibrin(ogen	fibrin(ogen	NN
cord-001835-0s7ok4uw	5435	11	)	)	-RRB-
cord-001835-0s7ok4uw	5435	12	proved	prove	VBD
cord-001835-0s7ok4uw	5435	13	to	to	TO
cord-001835-0s7ok4uw	5435	14	be	be	VB
cord-001835-0s7ok4uw	5435	15	involved	involve	VBN
cord-001835-0s7ok4uw	5435	16	in	in	IN
cord-001835-0s7ok4uw	5435	17	the	the	DT
cord-001835-0s7ok4uw	5435	18	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5435	19	cross	cross	NN
cord-001835-0s7ok4uw	5435	20	-	-	JJ
cord-001835-0s7ok4uw	5435	21	linking	link	VBG
cord-001835-0s7ok4uw	5435	22	more	more	RBR
cord-001835-0s7ok4uw	5435	23	readily	readily	RB
cord-001835-0s7ok4uw	5435	24	than	than	IN
cord-001835-0s7ok4uw	5435	25	those	those	DT
cord-001835-0s7ok4uw	5435	26	of	of	IN
cord-001835-0s7ok4uw	5435	27	unaffected	unaffected	JJ
cord-001835-0s7ok4uw	5435	28	molecules	molecule	NNS
cord-001835-0s7ok4uw	5435	29	.	.	.
cord-001835-0s7ok4uw	5436	1	The	the	DT
cord-001835-0s7ok4uw	5436	2	enhancing	enhance	VBG
cord-001835-0s7ok4uw	5436	3	role	role	NN
cord-001835-0s7ok4uw	5436	4	of	of	IN
cord-001835-0s7ok4uw	5436	5	the	the	DT
cord-001835-0s7ok4uw	5436	6	D	d	NN
cord-001835-0s7ok4uw	5436	7	:	:	:
cord-001835-0s7ok4uw	5436	8	D	d	NN
cord-001835-0s7ok4uw	5436	9	interaction	interaction	NN
cord-001835-0s7ok4uw	5436	10	under	under	IN
cord-001835-0s7ok4uw	5436	11	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5436	12	could	could	MD
cord-001835-0s7ok4uw	5436	13	be	be	VB
cord-001835-0s7ok4uw	5436	14	considered	consider	VBN
cord-001835-0s7ok4uw	5436	15	as	as	IN
cord-001835-0s7ok4uw	5436	16	an	an	DT
cord-001835-0s7ok4uw	5436	17	compensatory	compensatory	JJ
cord-001835-0s7ok4uw	5436	18	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5436	19	in	in	IN
cord-001835-0s7ok4uw	5436	20	the	the	DT
cord-001835-0s7ok4uw	5436	21	assembly	assembly	NN
cord-001835-0s7ok4uw	5436	22	of	of	IN
cord-001835-0s7ok4uw	5436	23	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5436	24	when	when	WRB
cord-001835-0s7ok4uw	5436	25	the	the	DT
cord-001835-0s7ok4uw	5436	26	D	d	NN
cord-001835-0s7ok4uw	5436	27	:	:	:
cord-001835-0s7ok4uw	5436	28	E	e	NN
cord-001835-0s7ok4uw	5436	29	interaction	interaction	NN
cord-001835-0s7ok4uw	5436	30	is	be	VBZ
cord-001835-0s7ok4uw	5436	31	impaired	impair	VBN
cord-001835-0s7ok4uw	5436	32	.	.	.
cord-001835-0s7ok4uw	5437	1	The	the	DT
cord-001835-0s7ok4uw	5437	2	experimental	experimental	JJ
cord-001835-0s7ok4uw	5437	3	data	datum	NNS
cord-001835-0s7ok4uw	5437	4	on	on	IN
cord-001835-0s7ok4uw	5437	5	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	5437	6	and	and	CC
cord-001835-0s7ok4uw	5437	7	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5437	8	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5437	9	acquired	acquire	VBN
cord-001835-0s7ok4uw	5437	10	in	in	IN
cord-001835-0s7ok4uw	5437	11	the	the	DT
cord-001835-0s7ok4uw	5437	12	present	present	JJ
cord-001835-0s7ok4uw	5437	13	study	study	NN
cord-001835-0s7ok4uw	5437	14	,	,	,
cord-001835-0s7ok4uw	5437	15	being	be	VBG
cord-001835-0s7ok4uw	5437	16	combined	combine	VBN
cord-001835-0s7ok4uw	5437	17	with	with	IN
cord-001835-0s7ok4uw	5437	18	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5437	19	earlier	early	JJR
cord-001835-0s7ok4uw	5437	20	findings	finding	NNS
cord-001835-0s7ok4uw	5437	21	,	,	,
cord-001835-0s7ok4uw	5437	22	make	make	VB
cord-001835-0s7ok4uw	5437	23	it	-PRON-	PRP
cord-001835-0s7ok4uw	5437	24	reasonable	reasonable	JJ
cord-001835-0s7ok4uw	5437	25	to	to	TO
cord-001835-0s7ok4uw	5437	26	suppose	suppose	VB
cord-001835-0s7ok4uw	5437	27	that	that	IN
cord-001835-0s7ok4uw	5437	28	the	the	DT
cord-001835-0s7ok4uw	5437	29	spatial	spatial	JJ
cord-001835-0s7ok4uw	5437	30	structure	structure	NN
cord-001835-0s7ok4uw	5437	31	of	of	IN
cord-001835-0s7ok4uw	5437	32	fibrinogen	fibrinogen	NN
cord-001835-0s7ok4uw	5437	33	could	could	MD
cord-001835-0s7ok4uw	5437	34	be	be	VB
cord-001835-0s7ok4uw	5437	35	evolutionarily	evolutionarily	RB
cord-001835-0s7ok4uw	5437	36	adapted	adapt	VBN
cord-001835-0s7ok4uw	5437	37	to	to	IN
cord-001835-0s7ok4uw	5437	38	some	some	DT
cord-001835-0s7ok4uw	5437	39	ROS	ROS	NNP
cord-001835-0s7ok4uw	5437	40	actions	action	NNS
cord-001835-0s7ok4uw	5437	41	detrimental	detrimental	JJ
cord-001835-0s7ok4uw	5437	42	to	to	IN
cord-001835-0s7ok4uw	5437	43	the	the	DT
cord-001835-0s7ok4uw	5437	44	protein	protein	NN
cord-001835-0s7ok4uw	5437	45	function	function	NN
cord-001835-0s7ok4uw	5437	46	.	.	.
cord-001835-0s7ok4uw	5438	1	The	the	DT
cord-001835-0s7ok4uw	5438	2	study	study	NN
cord-001835-0s7ok4uw	5438	3	was	be	VBD
cord-001835-0s7ok4uw	5438	4	supported	support	VBN
cord-001835-0s7ok4uw	5438	5	by	by	IN
cord-001835-0s7ok4uw	5438	6	the	the	DT
cord-001835-0s7ok4uw	5438	7	RFBR	RFBR	NNP
cord-001835-0s7ok4uw	5438	8	,	,	,
cord-001835-0s7ok4uw	5438	9	Research	research	NN
cord-001835-0s7ok4uw	5438	10	Projects	project	NNS
cord-001835-0s7ok4uw	5438	11	14	14	CD
cord-001835-0s7ok4uw	5438	12	-	-	HYPH
cord-001835-0s7ok4uw	5438	13	04	04	CD
cord-001835-0s7ok4uw	5438	14	-	-	HYPH
cord-001835-0s7ok4uw	5438	15	31897mol_a	31897mol_a	CD
cord-001835-0s7ok4uw	5438	16	and	and	CC
cord-001835-0s7ok4uw	5438	17	15	15	CD
cord-001835-0s7ok4uw	5438	18	-	-	HYPH
cord-001835-0s7ok4uw	5438	19	04	04	CD
cord-001835-0s7ok4uw	5438	20	-	-	HYPH
cord-001835-0s7ok4uw	5438	21	08188a	08188a	CD
cord-001835-0s7ok4uw	5438	22	.	.	.
cord-001835-0s7ok4uw	5439	1	Structural	structural	JJ
cord-001835-0s7ok4uw	5439	2	and	and	CC
cord-001835-0s7ok4uw	5439	3	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	5439	4	analysis	analysis	NN
cord-001835-0s7ok4uw	5439	5	of	of	IN
cord-001835-0s7ok4uw	5439	6	co	co	JJ
cord-001835-0s7ok4uw	5439	7	-	-	JJ
cord-001835-0s7ok4uw	5439	8	stimulation	stimulation	NN
cord-001835-0s7ok4uw	5439	9	receptor	receptor	NN
cord-001835-0s7ok4uw	5439	10	CD28	CD28	NNP
cord-001835-0s7ok4uw	5439	11	phosphopeptide	phosphopeptide	NN
cord-001835-0s7ok4uw	5439	12	interactions	interaction	NNS
cord-001835-0s7ok4uw	5439	13	with	with	IN
cord-001835-0s7ok4uw	5439	14	Grb2	Grb2	NNP
cord-001835-0s7ok4uw	5439	15	,	,	,
cord-001835-0s7ok4uw	5439	16	Gads	gads	UH
cord-001835-0s7ok4uw	5439	17	,	,	,
cord-001835-0s7ok4uw	5439	18	and	and	CC
cord-001835-0s7ok4uw	5439	19	PI3-kinese	PI3-kinese	NNP
cord-001835-0s7ok4uw	5439	20	SH2	SH2	NNP
cord-001835-0s7ok4uw	5439	21	domains	domain	NNS
cord-001835-0s7ok4uw	5440	1	In	in	IN
cord-001835-0s7ok4uw	5440	2	addition	addition	NN
cord-001835-0s7ok4uw	5440	3	to	to	IN
cord-001835-0s7ok4uw	5440	4	the	the	DT
cord-001835-0s7ok4uw	5440	5	signaling	signaling	NN
cord-001835-0s7ok4uw	5440	6	produced	produce	VBN
cord-001835-0s7ok4uw	5440	7	by	by	IN
cord-001835-0s7ok4uw	5440	8	the	the	DT
cord-001835-0s7ok4uw	5440	9	binding	binding	NN
cord-001835-0s7ok4uw	5440	10	of	of	IN
cord-001835-0s7ok4uw	5440	11	antigen	antigen	NN
cord-001835-0s7ok4uw	5440	12	-	-	HYPH
cord-001835-0s7ok4uw	5440	13	major	major	JJ
cord-001835-0s7ok4uw	5440	14	histocompatibility	histocompatibility	NN
cord-001835-0s7ok4uw	5440	15	complex	complex	NN
cord-001835-0s7ok4uw	5440	16	to	to	IN
cord-001835-0s7ok4uw	5440	17	Tcell	Tcell	NNP
cord-001835-0s7ok4uw	5440	18	receptors	receptor	NNS
cord-001835-0s7ok4uw	5440	19	,	,	,
cord-001835-0s7ok4uw	5440	20	co	co	JJ
cord-001835-0s7ok4uw	5440	21	-	-	JJ
cord-001835-0s7ok4uw	5440	22	stimulatory	stimulatory	JJ
cord-001835-0s7ok4uw	5440	23	signals	signal	NNS
cord-001835-0s7ok4uw	5440	24	from	from	IN
cord-001835-0s7ok4uw	5440	25	other	other	JJ
cord-001835-0s7ok4uw	5440	26	receptor	receptor	NN
cord-001835-0s7ok4uw	5440	27	-	-	HYPH
cord-001835-0s7ok4uw	5440	28	ligand	ligand	NN
cord-001835-0s7ok4uw	5440	29	interactions	interaction	NNS
cord-001835-0s7ok4uw	5440	30	are	be	VBP
cord-001835-0s7ok4uw	5440	31	required	require	VBN
cord-001835-0s7ok4uw	5440	32	for	for	IN
cord-001835-0s7ok4uw	5440	33	full	full	JJ
cord-001835-0s7ok4uw	5440	34	activation	activation	NN
cord-001835-0s7ok4uw	5440	35	of	of	IN
cord-001835-0s7ok4uw	5440	36	T	t	NN
cord-001835-0s7ok4uw	5440	37	-	-	HYPH
cord-001835-0s7ok4uw	5440	38	cells	cell	NNS
cord-001835-0s7ok4uw	5440	39	.	.	.
cord-001835-0s7ok4uw	5441	1	The	the	DT
cord-001835-0s7ok4uw	5441	2	CD28	CD28	NNP
cord-001835-0s7ok4uw	5441	3	receptor	receptor	NN
cord-001835-0s7ok4uw	5441	4	on	on	IN
cord-001835-0s7ok4uw	5441	5	the	the	DT
cord-001835-0s7ok4uw	5441	6	T	t	NN
cord-001835-0s7ok4uw	5441	7	-	-	HYPH
cord-001835-0s7ok4uw	5441	8	cell	cell	NN
cord-001835-0s7ok4uw	5441	9	surface	surface	NN
cord-001835-0s7ok4uw	5441	10	has	have	VBZ
cord-001835-0s7ok4uw	5441	11	been	be	VBN
cord-001835-0s7ok4uw	5441	12	well	well	RB
cord-001835-0s7ok4uw	5441	13	characterized	characterize	VBN
cord-001835-0s7ok4uw	5441	14	,	,	,
cord-001835-0s7ok4uw	5441	15	and	and	CC
cord-001835-0s7ok4uw	5441	16	the	the	DT
cord-001835-0s7ok4uw	5441	17	binding	binding	NN
cord-001835-0s7ok4uw	5441	18	of	of	IN
cord-001835-0s7ok4uw	5441	19	ligand	ligand	NN
cord-001835-0s7ok4uw	5441	20	to	to	IN
cord-001835-0s7ok4uw	5441	21	CD28	CD28	NNP
cord-001835-0s7ok4uw	5441	22	is	be	VBZ
cord-001835-0s7ok4uw	5441	23	critical	critical	JJ
cord-001835-0s7ok4uw	5441	24	for	for	IN
cord-001835-0s7ok4uw	5441	25	producing	produce	VBG
cord-001835-0s7ok4uw	5441	26	co	co	JJ
cord-001835-0s7ok4uw	5441	27	-	-	JJ
cord-001835-0s7ok4uw	5441	28	stimulatory	stimulatory	JJ
cord-001835-0s7ok4uw	5441	29	signals	signal	NNS
cord-001835-0s7ok4uw	5441	30	.	.	.
cord-001835-0s7ok4uw	5442	1	CD28	CD28	NNP
cord-001835-0s7ok4uw	5442	2	has	have	VBZ
cord-001835-0s7ok4uw	5443	1	no	no	DT
cord-001835-0s7ok4uw	5443	2	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5443	3	activity	activity	NN
cord-001835-0s7ok4uw	5443	4	and	and	CC
cord-001835-0s7ok4uw	5443	5	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5443	6	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	5443	7	region	region	NN
cord-001835-0s7ok4uw	5443	8	consists	consist	VBZ
cord-001835-0s7ok4uw	5443	9	of	of	IN
cord-001835-0s7ok4uw	5443	10	41	41	CD
cord-001835-0s7ok4uw	5443	11	amino	amino	JJ
cord-001835-0s7ok4uw	5443	12	acids	acid	NNS
cord-001835-0s7ok4uw	5443	13	that	that	WDT
cord-001835-0s7ok4uw	5443	14	contain	contain	VBP
cord-001835-0s7ok4uw	5443	15	the	the	DT
cord-001835-0s7ok4uw	5443	16	sequence	sequence	NN
cord-001835-0s7ok4uw	5443	17	YMNM	YMNM	NNP
cord-001835-0s7ok4uw	5443	18	,	,	,
cord-001835-0s7ok4uw	5443	19	in	in	IN
cord-001835-0s7ok4uw	5443	20	which	which	WDT
cord-001835-0s7ok4uw	5443	21	the	the	DT
cord-001835-0s7ok4uw	5443	22	tyrosine	tyrosine	NN
cord-001835-0s7ok4uw	5443	23	residue	residue	NN
cord-001835-0s7ok4uw	5443	24	is	be	VBZ
cord-001835-0s7ok4uw	5443	25	phosphorylated	phosphorylate	VBN
cord-001835-0s7ok4uw	5443	26	by	by	IN
cord-001835-0s7ok4uw	5443	27	kinase	kinase	NN
cord-001835-0s7ok4uw	5443	28	.	.	.
cord-001835-0s7ok4uw	5444	1	The	the	DT
cord-001835-0s7ok4uw	5444	2	phosphorylated	phosphorylated	JJ
cord-001835-0s7ok4uw	5444	3	sequence	sequence	NN
cord-001835-0s7ok4uw	5444	4	,	,	,
cord-001835-0s7ok4uw	5444	5	pYMNM	pymnm	UH
cord-001835-0s7ok4uw	5444	6	,	,	,
cord-001835-0s7ok4uw	5444	7	is	be	VBZ
cord-001835-0s7ok4uw	5444	8	recognized	recognize	VBN
cord-001835-0s7ok4uw	5444	9	by	by	IN
cord-001835-0s7ok4uw	5444	10	Src	Src	NNP
cord-001835-0s7ok4uw	5444	11	homology	homology	NN
cord-001835-0s7ok4uw	5444	12	2	2	CD
cord-001835-0s7ok4uw	5444	13	(	(	-LRB-
cord-001835-0s7ok4uw	5444	14	SH2	SH2	NNP
cord-001835-0s7ok4uw	5444	15	)	)	-RRB-
cord-001835-0s7ok4uw	5444	16	adaptor	adaptor	NN
cord-001835-0s7ok4uw	5444	17	proteins	protein	NNS
cord-001835-0s7ok4uw	5444	18	,	,	,
cord-001835-0s7ok4uw	5444	19	such	such	JJ
cord-001835-0s7ok4uw	5444	20	as	as	IN
cord-001835-0s7ok4uw	5444	21	growth	growth	NN
cord-001835-0s7ok4uw	5444	22	factor	factor	NN
cord-001835-0s7ok4uw	5444	23	receptor	receptor	NN
cord-001835-0s7ok4uw	5444	24	binding	bind	VBG
cord-001835-0s7ok4uw	5444	25	protein	protein	NN
cord-001835-0s7ok4uw	5444	26	2	2	CD
cord-001835-0s7ok4uw	5444	27	(	(	-LRB-
cord-001835-0s7ok4uw	5444	28	Grb2	Grb2	NNP
cord-001835-0s7ok4uw	5444	29	)	)	-RRB-
cord-001835-0s7ok4uw	5444	30	,	,	,
cord-001835-0s7ok4uw	5444	31	Grb2related	grb2related	JJ
cord-001835-0s7ok4uw	5444	32	adaptor	adaptor	NN
cord-001835-0s7ok4uw	5444	33	downstream	downstream	NN
cord-001835-0s7ok4uw	5444	34	(	(	-LRB-
cord-001835-0s7ok4uw	5444	35	Gads	Gads	NNP
cord-001835-0s7ok4uw	5444	36	)	)	-RRB-
cord-001835-0s7ok4uw	5444	37	,	,	,
cord-001835-0s7ok4uw	5444	38	and	and	CC
cord-001835-0s7ok4uw	5444	39	the	the	DT
cord-001835-0s7ok4uw	5444	40	phosphatidylinositol	phosphatidylinositol	JJ
cord-001835-0s7ok4uw	5444	41	3-kinase	3-kinase	CD
cord-001835-0s7ok4uw	5444	42	(	(	-LRB-
cord-001835-0s7ok4uw	5444	43	PI3-kinase	pi3-kinase	NN
cord-001835-0s7ok4uw	5444	44	)	)	-RRB-
cord-001835-0s7ok4uw	5444	45	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	5444	46	subunit	subunit	NN
cord-001835-0s7ok4uw	5444	47	,	,	,
cord-001835-0s7ok4uw	5444	48	p85	p85	NN
cord-001835-0s7ok4uw	5444	49	.	.	.
cord-001835-0s7ok4uw	5445	1	The	the	DT
cord-001835-0s7ok4uw	5445	2	consensus	consensus	NN
cord-001835-0s7ok4uw	5445	3	sequence	sequence	NN
cord-001835-0s7ok4uw	5445	4	for	for	IN
cord-001835-0s7ok4uw	5445	5	the	the	DT
cord-001835-0s7ok4uw	5445	6	binding	binding	NN
cord-001835-0s7ok4uw	5445	7	of	of	IN
cord-001835-0s7ok4uw	5446	1	Grb2	Grb2	NNP
cord-001835-0s7ok4uw	5446	2	SH2	SH2	NNP
cord-001835-0s7ok4uw	5446	3	and	and	CC
cord-001835-0s7ok4uw	5446	4	Gads	Gads	NNP
cord-001835-0s7ok4uw	5446	5	SH2	SH2	NNP
cord-001835-0s7ok4uw	5446	6	is	be	VBZ
cord-001835-0s7ok4uw	5446	7	pYXNX	pYXNX	NNS
cord-001835-0s7ok4uw	5446	8	,	,	,
cord-001835-0s7ok4uw	5446	9	and	and	CC
cord-001835-0s7ok4uw	5446	10	that	that	DT
cord-001835-0s7ok4uw	5446	11	of	of	IN
cord-001835-0s7ok4uw	5446	12	p85	p85	NNP
cord-001835-0s7ok4uw	5446	13	N	N	NNP
cord-001835-0s7ok4uw	5446	14	-	-	HYPH
cord-001835-0s7ok4uw	5446	15	terminus	terminus	NN
cord-001835-0s7ok4uw	5446	16	SH2	SH2	NNP
cord-001835-0s7ok4uw	5446	17	(	(	-LRB-
cord-001835-0s7ok4uw	5446	18	nSH2	nSH2	NNP
cord-001835-0s7ok4uw	5446	19	)	)	-RRB-
cord-001835-0s7ok4uw	5446	20	and	and	CC
cord-001835-0s7ok4uw	5446	21	C	c	NN
cord-001835-0s7ok4uw	5446	22	-	-	HYPH
cord-001835-0s7ok4uw	5446	23	terminus	terminus	NN
cord-001835-0s7ok4uw	5446	24	SH2	SH2	NNP
cord-001835-0s7ok4uw	5446	25	(	(	-LRB-
cord-001835-0s7ok4uw	5446	26	cSH2	cSH2	NNP
cord-001835-0s7ok4uw	5446	27	)	)	-RRB-
cord-001835-0s7ok4uw	5446	28	is	be	VBZ
cord-001835-0s7ok4uw	5446	29	pYXXM	pyxxm	JJ
cord-001835-0s7ok4uw	5446	30	.	.	.
cord-001835-0s7ok4uw	5447	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5447	2	reported	report	VBD
cord-001835-0s7ok4uw	5447	3	the	the	DT
cord-001835-0s7ok4uw	5447	4	high	high	JJ
cord-001835-0s7ok4uw	5447	5	-	-	HYPH
cord-001835-0s7ok4uw	5447	6	resolution	resolution	NN
cord-001835-0s7ok4uw	5447	7	crystal	crystal	NN
cord-001835-0s7ok4uw	5447	8	structure	structure	NN
cord-001835-0s7ok4uw	5447	9	of	of	IN
cord-001835-0s7ok4uw	5447	10	Grb2	Grb2	NNP
cord-001835-0s7ok4uw	5447	11	SH2	SH2	NNP
cord-001835-0s7ok4uw	5447	12	in	in	IN
cord-001835-0s7ok4uw	5447	13	complex	complex	NN
cord-001835-0s7ok4uw	5447	14	with	with	IN
cord-001835-0s7ok4uw	5447	15	the	the	DT
cord-001835-0s7ok4uw	5447	16	CD28	CD28	NNP
cord-001835-0s7ok4uw	5447	17	phosphopeptide	phosphopeptide	NN
cord-001835-0s7ok4uw	5448	1	[	[	-LRB-
cord-001835-0s7ok4uw	5448	2	Higo	Higo	NNP
cord-001835-0s7ok4uw	5448	3	et	et	NNP
cord-001835-0s7ok4uw	5448	4	al	al	NNP
cord-001835-0s7ok4uw	5448	5	.	.	.
cord-001835-0s7ok4uw	5449	1	,	,	,
cord-001835-0s7ok4uw	5449	2	PLOS	PLOS	NNP
cord-001835-0s7ok4uw	5449	3	ONE	one	CD
cord-001835-0s7ok4uw	5449	4	8	8	CD
cord-001835-0s7ok4uw	5450	1	,	,	,
cord-001835-0s7ok4uw	5450	2	e74482	e74482	NNP
cord-001835-0s7ok4uw	5450	3	,	,	,
cord-001835-0s7ok4uw	5450	4	2013	2013	CD
cord-001835-0s7ok4uw	5450	5	]	]	-RRB-
cord-001835-0s7ok4uw	5450	6	,	,	,
cord-001835-0s7ok4uw	5450	7	and	and	CC
cord-001835-0s7ok4uw	5450	8	recently	recently	RB
cord-001835-0s7ok4uw	5450	9	determined	determine	VBD
cord-001835-0s7ok4uw	5450	10	those	those	DT
cord-001835-0s7ok4uw	5450	11	of	of	IN
cord-001835-0s7ok4uw	5450	12	Gads	Gads	NNP
cord-001835-0s7ok4uw	5450	13	SH2	SH2	NNP
cord-001835-0s7ok4uw	5450	14	,	,	,
cord-001835-0s7ok4uw	5450	15	p85	p85	NNP
cord-001835-0s7ok4uw	5450	16	nSH2	nSH2	NNP
cord-001835-0s7ok4uw	5450	17	,	,	,
cord-001835-0s7ok4uw	5450	18	and	and	CC
cord-001835-0s7ok4uw	5450	19	p85	p85	NNP
cord-001835-0s7ok4uw	5450	20	cSH2	cSH2	NNPS
cord-001835-0s7ok4uw	5450	21	.	.	.
cord-001835-0s7ok4uw	5451	1	These	these	DT
cord-001835-0s7ok4uw	5451	2	data	datum	NNS
cord-001835-0s7ok4uw	5451	3	along	along	IN
cord-001835-0s7ok4uw	5451	4	with	with	IN
cord-001835-0s7ok4uw	5451	5	the	the	DT
cord-001835-0s7ok4uw	5451	6	results	result	NNS
cord-001835-0s7ok4uw	5451	7	of	of	IN
cord-001835-0s7ok4uw	5451	8	binding	bind	VBG
cord-001835-0s7ok4uw	5451	9	thermodynamics	thermodynamic	NNS
cord-001835-0s7ok4uw	5451	10	analyzed	analyze	VBD
cord-001835-0s7ok4uw	5451	11	using	use	VBG
cord-001835-0s7ok4uw	5451	12	isothermal	isothermal	JJ
cord-001835-0s7ok4uw	5451	13	titration	titration	NN
cord-001835-0s7ok4uw	5451	14	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	5451	15	,	,	,
cord-001835-0s7ok4uw	5451	16	helped	help	VBD
cord-001835-0s7ok4uw	5451	17	to	to	TO
cord-001835-0s7ok4uw	5451	18	elucidate	elucidate	VB
cord-001835-0s7ok4uw	5451	19	the	the	DT
cord-001835-0s7ok4uw	5451	20	molecular	molecular	JJ
cord-001835-0s7ok4uw	5451	21	recognition	recognition	NN
cord-001835-0s7ok4uw	5451	22	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	5451	23	of	of	IN
cord-001835-0s7ok4uw	5451	24	CD28	CD28	NNP
cord-001835-0s7ok4uw	5451	25	by	by	IN
cord-001835-0s7ok4uw	5451	26	adaptor	adaptor	NN
cord-001835-0s7ok4uw	5451	27	proteins	protein	NNS
cord-001835-0s7ok4uw	5451	28	.	.	.
cord-001835-0s7ok4uw	5452	1	The	the	DT
cord-001835-0s7ok4uw	5452	2	SH2	SH2	NNP
cord-001835-0s7ok4uw	5452	3	proteins	protein	NNS
cord-001835-0s7ok4uw	5452	4	were	be	VBD
cord-001835-0s7ok4uw	5452	5	overexpressed	overexpresse	VBN
cord-001835-0s7ok4uw	5452	6	in	in	IN
cord-001835-0s7ok4uw	5452	7	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	5452	8	coli	coli	NNS
cord-001835-0s7ok4uw	5452	9	,	,	,
cord-001835-0s7ok4uw	5452	10	and	and	CC
cord-001835-0s7ok4uw	5452	11	were	be	VBD
cord-001835-0s7ok4uw	5452	12	purified	purify	VBN
cord-001835-0s7ok4uw	5452	13	using	use	VBG
cord-001835-0s7ok4uw	5452	14	affinity	affinity	NN
cord-001835-0s7ok4uw	5452	15	and	and	CC
cord-001835-0s7ok4uw	5452	16	gel	gel	NN
cord-001835-0s7ok4uw	5452	17	-	-	HYPH
cord-001835-0s7ok4uw	5452	18	filtration	filtration	NN
cord-001835-0s7ok4uw	5452	19	chromatography	chromatography	NN
cord-001835-0s7ok4uw	5452	20	.	.	.
cord-001835-0s7ok4uw	5453	1	The	the	DT
cord-001835-0s7ok4uw	5453	2	CD28	CD28	NNP
cord-001835-0s7ok4uw	5453	3	phosphopeptides	phosphopeptides	NNP
cord-001835-0s7ok4uw	5453	4	,	,	,
cord-001835-0s7ok4uw	5453	5	8-residue	8-residue	CD
cord-001835-0s7ok4uw	5453	6	(	(	-LRB-
cord-001835-0s7ok4uw	5453	7	OctP	OctP	NNP
cord-001835-0s7ok4uw	5453	8	)	)	-RRB-
cord-001835-0s7ok4uw	5453	9	and	and	CC
cord-001835-0s7ok4uw	5453	10	12-residue	12-residue	CD
cord-001835-0s7ok4uw	5453	11	(	(	-LRB-
cord-001835-0s7ok4uw	5453	12	DdcP02	ddcp02	NN
cord-001835-0s7ok4uw	5453	13	)	)	-RRB-
cord-001835-0s7ok4uw	5453	14	,	,	,
cord-001835-0s7ok4uw	5453	15	were	be	VBD
cord-001835-0s7ok4uw	5453	16	synthesized	synthesize	VBN
cord-001835-0s7ok4uw	5453	17	using	use	VBG
cord-001835-0s7ok4uw	5453	18	the	the	DT
cord-001835-0s7ok4uw	5453	19	solidphase	solidphase	NNP
cord-001835-0s7ok4uw	5453	20	supported	support	VBN
cord-001835-0s7ok4uw	5453	21	technique	technique	NN
cord-001835-0s7ok4uw	5453	22	,	,	,
cord-001835-0s7ok4uw	5453	23	and	and	CC
cord-001835-0s7ok4uw	5453	24	were	be	VBD
cord-001835-0s7ok4uw	5453	25	purified	purify	VBN
cord-001835-0s7ok4uw	5453	26	using	use	VBG
cord-001835-0s7ok4uw	5453	27	reversed	reverse	VBN
cord-001835-0s7ok4uw	5453	28	-	-	HYPH
cord-001835-0s7ok4uw	5453	29	phase	phase	NN
cord-001835-0s7ok4uw	5453	30	chromatography	chromatography	NN
cord-001835-0s7ok4uw	5453	31	.	.	.
cord-001835-0s7ok4uw	5454	1	The	the	DT
cord-001835-0s7ok4uw	5454	2	crystals	crystal	NNS
cord-001835-0s7ok4uw	5454	3	were	be	VBD
cord-001835-0s7ok4uw	5454	4	obtained	obtain	VBN
cord-001835-0s7ok4uw	5454	5	by	by	IN
cord-001835-0s7ok4uw	5454	6	the	the	DT
cord-001835-0s7ok4uw	5454	7	hanging	hang	VBG
cord-001835-0s7ok4uw	5454	8	-	-	HYPH
cord-001835-0s7ok4uw	5454	9	drop	drop	NN
cord-001835-0s7ok4uw	5454	10	vapor	vapor	NN
cord-001835-0s7ok4uw	5454	11	diffusion	diffusion	NN
cord-001835-0s7ok4uw	5454	12	method	method	NN
cord-001835-0s7ok4uw	5454	13	.	.	.
cord-001835-0s7ok4uw	5455	1	X	x	NN
cord-001835-0s7ok4uw	5455	2	-	-	NN
cord-001835-0s7ok4uw	5455	3	ray	ray	NN
cord-001835-0s7ok4uw	5455	4	diffraction	diffraction	NN
cord-001835-0s7ok4uw	5455	5	data	datum	NNS
cord-001835-0s7ok4uw	5455	6	were	be	VBD
cord-001835-0s7ok4uw	5455	7	collected	collect	VBN
cord-001835-0s7ok4uw	5455	8	at	at	IN
cord-001835-0s7ok4uw	5455	9	synchrotron	synchrotron	NN
cord-001835-0s7ok4uw	5455	10	radiation	radiation	NN
cord-001835-0s7ok4uw	5455	11	facilities	facility	NNS
cord-001835-0s7ok4uw	5455	12	,	,	,
cord-001835-0s7ok4uw	5455	13	and	and	CC
cord-001835-0s7ok4uw	5455	14	the	the	DT
cord-001835-0s7ok4uw	5455	15	structures	structure	NNS
cord-001835-0s7ok4uw	5455	16	were	be	VBD
cord-001835-0s7ok4uw	5455	17	determined	determine	VBN
cord-001835-0s7ok4uw	5455	18	by	by	IN
cord-001835-0s7ok4uw	5455	19	the	the	DT
cord-001835-0s7ok4uw	5455	20	molecular	molecular	JJ
cord-001835-0s7ok4uw	5455	21	replacement	replacement	NN
cord-001835-0s7ok4uw	5455	22	method	method	NN
cord-001835-0s7ok4uw	5455	23	.	.	.
cord-001835-0s7ok4uw	5456	1	The	the	DT
cord-001835-0s7ok4uw	5456	2	models	model	NNS
cord-001835-0s7ok4uw	5456	3	of	of	IN
cord-001835-0s7ok4uw	5456	4	Grb2	Grb2	NNP
cord-001835-0s7ok4uw	5456	5	SH2	SH2	NNP
cord-001835-0s7ok4uw	5456	6	,	,	,
cord-001835-0s7ok4uw	5456	7	Gads	Gads	NNP
cord-001835-0s7ok4uw	5456	8	SH2	SH2	NNP
cord-001835-0s7ok4uw	5456	9	,	,	,
cord-001835-0s7ok4uw	5456	10	p85	p85	NNP
cord-001835-0s7ok4uw	5456	11	nSH2	nSH2	NNP
cord-001835-0s7ok4uw	5456	12	,	,	,
cord-001835-0s7ok4uw	5456	13	and	and	CC
cord-001835-0s7ok4uw	5456	14	p85	p85	NNP
cord-001835-0s7ok4uw	5456	15	cSH2	cSH2	NNPS
cord-001835-0s7ok4uw	5456	16	in	in	IN
cord-001835-0s7ok4uw	5456	17	complex	complex	NN
cord-001835-0s7ok4uw	5456	18	with	with	IN
cord-001835-0s7ok4uw	5456	19	OctP	OctP	NNP
cord-001835-0s7ok4uw	5456	20	were	be	VBD
cord-001835-0s7ok4uw	5456	21	refined	refine	VBN
cord-001835-0s7ok4uw	5456	22	at	at	IN
cord-001835-0s7ok4uw	5456	23	1.35	1.35	CD
cord-001835-0s7ok4uw	5456	24	,	,	,
cord-001835-0s7ok4uw	5456	25	1.2	1.2	CD
cord-001835-0s7ok4uw	5456	26	,	,	,
cord-001835-0s7ok4uw	5456	27	1.0	1.0	CD
cord-001835-0s7ok4uw	5456	28	,	,	,
cord-001835-0s7ok4uw	5456	29	and	and	CC
cord-001835-0s7ok4uw	5456	30	1.1	1.1	CD
cord-001835-0s7ok4uw	5456	31	Å	å	NN
cord-001835-0s7ok4uw	5456	32	resolutions	resolution	NNS
cord-001835-0s7ok4uw	5456	33	,	,	,
cord-001835-0s7ok4uw	5456	34	respectively	respectively	RB
cord-001835-0s7ok4uw	5456	35	.	.	.
cord-001835-0s7ok4uw	5457	1	The	the	DT
cord-001835-0s7ok4uw	5457	2	crystal	crystal	NN
cord-001835-0s7ok4uw	5457	3	structures	structure	NNS
cord-001835-0s7ok4uw	5457	4	showed	show	VBD
cord-001835-0s7ok4uw	5457	5	that	that	IN
cord-001835-0s7ok4uw	5457	6	the	the	DT
cord-001835-0s7ok4uw	5457	7	phosphotyrosine	phosphotyrosine	NN
cord-001835-0s7ok4uw	5457	8	phosphate	phosphate	NN
cord-001835-0s7ok4uw	5457	9	moiety	moiety	NN
cord-001835-0s7ok4uw	5457	10	directly	directly	RB
cord-001835-0s7ok4uw	5457	11	interacted	interact	VBD
cord-001835-0s7ok4uw	5457	12	with	with	IN
cord-001835-0s7ok4uw	5457	13	the	the	DT
cord-001835-0s7ok4uw	5457	14	side	side	NN
cord-001835-0s7ok4uw	5457	15	-	-	HYPH
cord-001835-0s7ok4uw	5457	16	chain	chain	NN
cord-001835-0s7ok4uw	5457	17	of	of	IN
cord-001835-0s7ok4uw	5457	18	arginine	arginine	NN
cord-001835-0s7ok4uw	5457	19	in	in	IN
cord-001835-0s7ok4uw	5457	20	SH2	SH2	NNP
cord-001835-0s7ok4uw	5457	21	,	,	,
cord-001835-0s7ok4uw	5457	22	which	which	WDT
cord-001835-0s7ok4uw	5457	23	is	be	VBZ
cord-001835-0s7ok4uw	5457	24	common	common	JJ
cord-001835-0s7ok4uw	5457	25	in	in	IN
cord-001835-0s7ok4uw	5457	26	all	all	DT
cord-001835-0s7ok4uw	5457	27	complex	complex	JJ
cord-001835-0s7ok4uw	5457	28	structures	structure	NNS
cord-001835-0s7ok4uw	5457	29	.	.	.
cord-001835-0s7ok4uw	5458	1	In	in	IN
cord-001835-0s7ok4uw	5458	2	the	the	DT
cord-001835-0s7ok4uw	5458	3	Grb2	Grb2	NNP
cord-001835-0s7ok4uw	5458	4	SH2	SH2	NNP
cord-001835-0s7ok4uw	5458	5	and	and	CC
cord-001835-0s7ok4uw	5458	6	Gads	Gads	NNP
cord-001835-0s7ok4uw	5458	7	SH2	SH2	NNP
cord-001835-0s7ok4uw	5458	8	complexes	complex	NNS
cord-001835-0s7ok4uw	5458	9	,	,	,
cord-001835-0s7ok4uw	5458	10	the	the	DT
cord-001835-0s7ok4uw	5458	11	side	side	NN
cord-001835-0s7ok4uw	5458	12	-	-	HYPH
cord-001835-0s7ok4uw	5458	13	chain	chain	NN
cord-001835-0s7ok4uw	5458	14	of	of	IN
cord-001835-0s7ok4uw	5458	15	asparagine	asparagine	NN
cord-001835-0s7ok4uw	5458	16	at	at	IN
cord-001835-0s7ok4uw	5458	17	the	the	DT
cord-001835-0s7ok4uw	5458	18	pY12	pY12	NNP
cord-001835-0s7ok4uw	5458	19	position	position	NN
cord-001835-0s7ok4uw	5458	20	forms	form	VBZ
cord-001835-0s7ok4uw	5458	21	a	a	DT
cord-001835-0s7ok4uw	5458	22	pair	pair	NN
cord-001835-0s7ok4uw	5458	23	of	of	IN
cord-001835-0s7ok4uw	5458	24	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	5458	25	bonds	bond	NNS
cord-001835-0s7ok4uw	5458	26	with	with	IN
cord-001835-0s7ok4uw	5458	27	the	the	DT
cord-001835-0s7ok4uw	5458	28	main	main	JJ
cord-001835-0s7ok4uw	5458	29	-	-	HYPH
cord-001835-0s7ok4uw	5458	30	chain	chain	NN
cord-001835-0s7ok4uw	5458	31	amide	amide	NN
cord-001835-0s7ok4uw	5458	32	and	and	CC
cord-001835-0s7ok4uw	5458	33	carbonyl	carbonyl	NN
cord-001835-0s7ok4uw	5458	34	groups	group	NNS
cord-001835-0s7ok4uw	5458	35	of	of	IN
cord-001835-0s7ok4uw	5458	36	lysine	lysine	NN
cord-001835-0s7ok4uw	5458	37	in	in	IN
cord-001835-0s7ok4uw	5458	38	SH2	SH2	NNP
cord-001835-0s7ok4uw	5458	39	.	.	.
cord-001835-0s7ok4uw	5459	1	Alternatively	alternatively	RB
cord-001835-0s7ok4uw	5459	2	,	,	,
cord-001835-0s7ok4uw	5459	3	in	in	IN
cord-001835-0s7ok4uw	5459	4	the	the	DT
cord-001835-0s7ok4uw	5459	5	p85	p85	NNP
cord-001835-0s7ok4uw	5459	6	nSH2	nSH2	NNP
cord-001835-0s7ok4uw	5459	7	and	and	CC
cord-001835-0s7ok4uw	5460	1	cSH2	cSH2	NNP
cord-001835-0s7ok4uw	5460	2	complexes	complex	NNS
cord-001835-0s7ok4uw	5460	3	,	,	.
cord-001835-0s7ok4uw	5461	1	the	the	DT
cord-001835-0s7ok4uw	5461	2	side	side	NN
cord-001835-0s7ok4uw	5461	3	-	-	HYPH
cord-001835-0s7ok4uw	5461	4	chain	chain	NN
cord-001835-0s7ok4uw	5461	5	of	of	IN
cord-001835-0s7ok4uw	5461	6	methionine	methionine	NN
cord-001835-0s7ok4uw	5461	7	at	at	IN
cord-001835-0s7ok4uw	5461	8	the	the	DT
cord-001835-0s7ok4uw	5461	9	pY13	py13	NN
cord-001835-0s7ok4uw	5461	10	position	position	NN
cord-001835-0s7ok4uw	5461	11	is	be	VBZ
cord-001835-0s7ok4uw	5461	12	located	locate	VBN
cord-001835-0s7ok4uw	5461	13	in	in	IN
cord-001835-0s7ok4uw	5461	14	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5461	15	pockets	pocket	NNS
cord-001835-0s7ok4uw	5461	16	of	of	IN
cord-001835-0s7ok4uw	5461	17	nSH2	nSH2	NNP
cord-001835-0s7ok4uw	5461	18	and	and	CC
cord-001835-0s7ok4uw	5461	19	cSH2	cSH2	NNPS
cord-001835-0s7ok4uw	5461	20	,	,	,
cord-001835-0s7ok4uw	5461	21	in	in	IN
cord-001835-0s7ok4uw	5461	22	which	which	WDT
cord-001835-0s7ok4uw	5461	23	the	the	DT
cord-001835-0s7ok4uw	5461	24	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5461	25	interactions	interaction	NNS
cord-001835-0s7ok4uw	5461	26	of	of	IN
cord-001835-0s7ok4uw	5461	27	cSH2	cSH2	NNP
cord-001835-0s7ok4uw	5461	28	would	would	MD
cord-001835-0s7ok4uw	5461	29	be	be	VB
cord-001835-0s7ok4uw	5461	30	stronger	strong	JJR
cord-001835-0s7ok4uw	5461	31	than	than	IN
cord-001835-0s7ok4uw	5461	32	those	those	DT
cord-001835-0s7ok4uw	5461	33	of	of	IN
cord-001835-0s7ok4uw	5461	34	nSH2	nSH2	NNP
cord-001835-0s7ok4uw	5461	35	.	.	.
cord-001835-0s7ok4uw	5462	1	This	this	DT
cord-001835-0s7ok4uw	5462	2	idea	idea	NN
cord-001835-0s7ok4uw	5462	3	is	be	VBZ
cord-001835-0s7ok4uw	5462	4	supported	support	VBN
cord-001835-0s7ok4uw	5462	5	by	by	IN
cord-001835-0s7ok4uw	5462	6	the	the	DT
cord-001835-0s7ok4uw	5462	7	observed	observe	VBN
cord-001835-0s7ok4uw	5462	8	binding	bind	VBG
cord-001835-0s7ok4uw	5462	9	thermodynamics	thermodynamic	NNS
cord-001835-0s7ok4uw	5462	10	.	.	.
cord-001835-0s7ok4uw	5463	1	The	the	DT
cord-001835-0s7ok4uw	5463	2	binding	bind	VBG
cord-001835-0s7ok4uw	5463	3	affinity	affinity	NN
cord-001835-0s7ok4uw	5463	4	of	of	IN
cord-001835-0s7ok4uw	5463	5	cSH2	cSH2	NNP
cord-001835-0s7ok4uw	5463	6	to	to	IN
cord-001835-0s7ok4uw	5463	7	DdcP02	DdcP02	NNP
cord-001835-0s7ok4uw	5463	8	,	,	,
cord-001835-0s7ok4uw	5463	9	because	because	IN
cord-001835-0s7ok4uw	5463	10	of	of	IN
cord-001835-0s7ok4uw	5463	11	a	a	DT
cord-001835-0s7ok4uw	5463	12	favorable	favorable	JJ
cord-001835-0s7ok4uw	5463	13	enthalpy	enthalpy	NN
cord-001835-0s7ok4uw	5463	14	change	change	NN
cord-001835-0s7ok4uw	5463	15	,	,	,
cord-001835-0s7ok4uw	5463	16	is	be	VBZ
cord-001835-0s7ok4uw	5463	17	about	about	RB
cord-001835-0s7ok4uw	5463	18	10-fold	10-fold	JJ
cord-001835-0s7ok4uw	5463	19	higher	high	JJR
cord-001835-0s7ok4uw	5463	20	than	than	IN
cord-001835-0s7ok4uw	5463	21	that	that	DT
cord-001835-0s7ok4uw	5463	22	of	of	IN
cord-001835-0s7ok4uw	5463	23	nSH2	nSH2	NNP
cord-001835-0s7ok4uw	5463	24	.	.	.
cord-001835-0s7ok4uw	5464	1	The	the	DT
cord-001835-0s7ok4uw	5464	2	binding	bind	VBG
cord-001835-0s7ok4uw	5464	3	affinity	affinity	NN
cord-001835-0s7ok4uw	5464	4	of	of	IN
cord-001835-0s7ok4uw	5464	5	Grb2	Grb2	NNP
cord-001835-0s7ok4uw	5464	6	SH2	SH2	NNP
cord-001835-0s7ok4uw	5464	7	to	to	IN
cord-001835-0s7ok4uw	5464	8	DdcP02	DdcP02	NNP
cord-001835-0s7ok4uw	5464	9	is	be	VBZ
cord-001835-0s7ok4uw	5464	10	similar	similar	JJ
cord-001835-0s7ok4uw	5464	11	to	to	IN
cord-001835-0s7ok4uw	5464	12	that	that	DT
cord-001835-0s7ok4uw	5464	13	of	of	IN
cord-001835-0s7ok4uw	5464	14	Gads	Gads	NNP
cord-001835-0s7ok4uw	5464	15	SH2	SH2	NNP
cord-001835-0s7ok4uw	5464	16	to	to	IN
cord-001835-0s7ok4uw	5464	17	DdcP02	DdcP02	NNP
cord-001835-0s7ok4uw	5464	18	,	,	,
cord-001835-0s7ok4uw	5464	19	and	and	CC
cord-001835-0s7ok4uw	5464	20	is	be	VBZ
cord-001835-0s7ok4uw	5464	21	about	about	RB
cord-001835-0s7ok4uw	5464	22	10-fold	10-fold	JJ
cord-001835-0s7ok4uw	5464	23	lower	low	JJR
cord-001835-0s7ok4uw	5464	24	than	than	IN
cord-001835-0s7ok4uw	5464	25	that	that	DT
cord-001835-0s7ok4uw	5464	26	of	of	IN
cord-001835-0s7ok4uw	5464	27	nSH2	nSH2	NNP
cord-001835-0s7ok4uw	5464	28	to	to	IN
cord-001835-0s7ok4uw	5464	29	DdcP02	DdcP02	NNP
cord-001835-0s7ok4uw	5464	30	.	.	.
cord-001835-0s7ok4uw	5465	1	These	these	DT
cord-001835-0s7ok4uw	5465	2	results	result	NNS
cord-001835-0s7ok4uw	5465	3	indicate	indicate	VBP
cord-001835-0s7ok4uw	5465	4	that	that	IN
cord-001835-0s7ok4uw	5465	5	the	the	DT
cord-001835-0s7ok4uw	5465	6	contribution	contribution	NN
cord-001835-0s7ok4uw	5465	7	of	of	IN
cord-001835-0s7ok4uw	5465	8	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5465	9	interactions	interaction	NNS
cord-001835-0s7ok4uw	5465	10	of	of	IN
cord-001835-0s7ok4uw	5465	11	nSH2	nSH2	NNP
cord-001835-0s7ok4uw	5465	12	and	and	CC
cord-001835-0s7ok4uw	5465	13	cSH2	cSH2	NNPS
cord-001835-0s7ok4uw	5465	14	at	at	IN
cord-001835-0s7ok4uw	5465	15	the	the	DT
cord-001835-0s7ok4uw	5465	16	pY13	py13	NN
cord-001835-0s7ok4uw	5465	17	position	position	NN
cord-001835-0s7ok4uw	5465	18	are	be	VBP
cord-001835-0s7ok4uw	5465	19	stronger	strong	JJR
cord-001835-0s7ok4uw	5465	20	than	than	IN
cord-001835-0s7ok4uw	5465	21	those	those	DT
cord-001835-0s7ok4uw	5465	22	of	of	IN
cord-001835-0s7ok4uw	5465	23	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	5465	24	bonds	bond	NNS
cord-001835-0s7ok4uw	5465	25	of	of	IN
cord-001835-0s7ok4uw	5465	26	Grb2	Grb2	NNP
cord-001835-0s7ok4uw	5465	27	SH2	SH2	NNP
cord-001835-0s7ok4uw	5465	28	and	and	CC
cord-001835-0s7ok4uw	5465	29	Gads	Gads	NNP
cord-001835-0s7ok4uw	5465	30	SH2	SH2	NNP
cord-001835-0s7ok4uw	5465	31	at	at	IN
cord-001835-0s7ok4uw	5465	32	the	the	DT
cord-001835-0s7ok4uw	5465	33	pY12	pY12	NNP
cord-001835-0s7ok4uw	5465	34	position	position	NN
cord-001835-0s7ok4uw	5465	35	.	.	.
cord-001835-0s7ok4uw	5466	1	Novel	novel	JJ
cord-001835-0s7ok4uw	5466	2	kinetochore	kinetochore	NN
cord-001835-0s7ok4uw	5466	3	protein	protein	NN
cord-001835-0s7ok4uw	5466	4	complex	complex	NN
cord-001835-0s7ok4uw	5466	5	from	from	IN
cord-001835-0s7ok4uw	5466	6	silkworm	silkworm	NN
cord-001835-0s7ok4uw	5466	7	holocentric	holocentric	NNP
cord-001835-0s7ok4uw	5466	8	chromosomes	chromosome	NNS
cord-001835-0s7ok4uw	5466	9	Takahiro	Takahiro	NNP
cord-001835-0s7ok4uw	5466	10	Kusakabe	Kusakabe	NNP
cord-001835-0s7ok4uw	5466	11	1	1	CD
cord-001835-0s7ok4uw	5467	1	,	,	,
cord-001835-0s7ok4uw	5467	2	Hiroaki	Hiroaki	NNP
cord-001835-0s7ok4uw	5467	3	Mon	Mon	NNP
cord-001835-0s7ok4uw	5467	4	1	1	CD
cord-001835-0s7ok4uw	5467	5	,	,	,
cord-001835-0s7ok4uw	5467	6	JaeMan	JaeMan	NNP
cord-001835-0s7ok4uw	5467	7	Lee	Lee	NNP
cord-001835-0s7ok4uw	5467	8	1	1	CD
cord-001835-0s7ok4uw	5467	9	1	1	CD
cord-001835-0s7ok4uw	5468	1	The	the	DT
cord-001835-0s7ok4uw	5468	2	kinetochore	kinetochore	NN
cord-001835-0s7ok4uw	5468	3	,	,	,
cord-001835-0s7ok4uw	5468	4	which	which	WDT
cord-001835-0s7ok4uw	5468	5	consists	consist	VBZ
cord-001835-0s7ok4uw	5468	6	of	of	IN
cord-001835-0s7ok4uw	5468	7	centromere	centromere	NN
cord-001835-0s7ok4uw	5468	8	DNA	DNA	NNP
cord-001835-0s7ok4uw	5468	9	and	and	CC
cord-001835-0s7ok4uw	5468	10	a	a	DT
cord-001835-0s7ok4uw	5468	11	multilayered	multilayered	JJ
cord-001835-0s7ok4uw	5468	12	protein	protein	NN
cord-001835-0s7ok4uw	5468	13	complex	complex	NN
cord-001835-0s7ok4uw	5468	14	,	,	,
cord-001835-0s7ok4uw	5468	15	plays	play	VBZ
cord-001835-0s7ok4uw	5468	16	important	important	JJ
cord-001835-0s7ok4uw	5468	17	roles	role	NNS
cord-001835-0s7ok4uw	5468	18	in	in	IN
cord-001835-0s7ok4uw	5468	19	chromosome	chromosome	NN
cord-001835-0s7ok4uw	5468	20	organization	organization	NN
cord-001835-0s7ok4uw	5468	21	and	and	CC
cord-001835-0s7ok4uw	5468	22	segregation	segregation	NN
cord-001835-0s7ok4uw	5468	23	.	.	.
cord-001835-0s7ok4uw	5469	1	Interactions	interaction	NNS
cord-001835-0s7ok4uw	5469	2	between	between	IN
cord-001835-0s7ok4uw	5469	3	chromosomes	chromosome	NNS
cord-001835-0s7ok4uw	5469	4	and	and	CC
cord-001835-0s7ok4uw	5469	5	spindle	spindle	NN
cord-001835-0s7ok4uw	5469	6	microtubules	microtubule	NNS
cord-001835-0s7ok4uw	5469	7	allow	allow	VBP
cord-001835-0s7ok4uw	5469	8	chromosomes	chromosome	NNS
cord-001835-0s7ok4uw	5469	9	to	to	IN
cord-001835-0s7ok4uw	5469	10	congress	congress	NNP
cord-001835-0s7ok4uw	5469	11	to	to	IN
cord-001835-0s7ok4uw	5469	12	the	the	DT
cord-001835-0s7ok4uw	5469	13	middle	middle	NN
cord-001835-0s7ok4uw	5469	14	of	of	IN
cord-001835-0s7ok4uw	5469	15	the	the	DT
cord-001835-0s7ok4uw	5469	16	cell	cell	NN
cord-001835-0s7ok4uw	5469	17	,	,	,
cord-001835-0s7ok4uw	5469	18	and	and	CC
cord-001835-0s7ok4uw	5469	19	to	to	TO
cord-001835-0s7ok4uw	5469	20	segregate	segregate	VB
cord-001835-0s7ok4uw	5469	21	the	the	DT
cord-001835-0s7ok4uw	5469	22	sister	sister	NN
cord-001835-0s7ok4uw	5469	23	chromatids	chromatid	NNS
cord-001835-0s7ok4uw	5469	24	into	into	IN
cord-001835-0s7ok4uw	5469	25	daughter	daughter	NN
cord-001835-0s7ok4uw	5469	26	cells	cell	NNS
cord-001835-0s7ok4uw	5469	27	in	in	IN
cord-001835-0s7ok4uw	5469	28	mitosis	mitosis	NN
cord-001835-0s7ok4uw	5469	29	,	,	,
cord-001835-0s7ok4uw	5469	30	which	which	WDT
cord-001835-0s7ok4uw	5469	31	is	be	VBZ
cord-001835-0s7ok4uw	5469	32	followed	follow	VBN
cord-001835-0s7ok4uw	5469	33	cytokinesis	cytokinesis	NN
cord-001835-0s7ok4uw	5469	34	.	.	.
cord-001835-0s7ok4uw	5470	1	In	in	IN
cord-001835-0s7ok4uw	5470	2	contrast	contrast	NN
cord-001835-0s7ok4uw	5470	3	to	to	IN
cord-001835-0s7ok4uw	5470	4	monocentric	monocentric	JJ
cord-001835-0s7ok4uw	5470	5	chromosomes	chromosome	NNS
cord-001835-0s7ok4uw	5470	6	,	,	,
cord-001835-0s7ok4uw	5470	7	in	in	IN
cord-001835-0s7ok4uw	5470	8	which	which	WDT
cord-001835-0s7ok4uw	5470	9	the	the	DT
cord-001835-0s7ok4uw	5470	10	centromere	centromere	NN
cord-001835-0s7ok4uw	5470	11	is	be	VBZ
cord-001835-0s7ok4uw	5470	12	normally	normally	RB
cord-001835-0s7ok4uw	5470	13	present	present	JJ
cord-001835-0s7ok4uw	5470	14	at	at	IN
cord-001835-0s7ok4uw	5470	15	a	a	DT
cord-001835-0s7ok4uw	5470	16	single	single	JJ
cord-001835-0s7ok4uw	5470	17	region	region	NN
cord-001835-0s7ok4uw	5470	18	on	on	IN
cord-001835-0s7ok4uw	5470	19	each	each	DT
cord-001835-0s7ok4uw	5470	20	chromosome	chromosome	NN
cord-001835-0s7ok4uw	5470	21	,	,	,
cord-001835-0s7ok4uw	5470	22	the	the	DT
cord-001835-0s7ok4uw	5470	23	holocentric	holocentric	NN
cord-001835-0s7ok4uw	5470	24	chromosomes	chromosome	NNS
cord-001835-0s7ok4uw	5470	25	have	have	VBP
cord-001835-0s7ok4uw	5470	26	centromeric	centromeric	JJ
cord-001835-0s7ok4uw	5470	27	activity	activity	NN
cord-001835-0s7ok4uw	5470	28	along	along	IN
cord-001835-0s7ok4uw	5470	29	the	the	DT
cord-001835-0s7ok4uw	5470	30	entire	entire	JJ
cord-001835-0s7ok4uw	5470	31	length	length	NN
cord-001835-0s7ok4uw	5470	32	of	of	IN
cord-001835-0s7ok4uw	5470	33	the	the	DT
cord-001835-0s7ok4uw	5470	34	chromosome	chromosome	NN
cord-001835-0s7ok4uw	5470	35	.	.	.
cord-001835-0s7ok4uw	5471	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5471	2	has	have	VBZ
cord-001835-0s7ok4uw	5471	3	been	be	VBN
cord-001835-0s7ok4uw	5471	4	known	know	VBN
cord-001835-0s7ok4uw	5471	5	that	that	IN
cord-001835-0s7ok4uw	5471	6	the	the	DT
cord-001835-0s7ok4uw	5471	7	silkworm	silkworm	NN
cord-001835-0s7ok4uw	5471	8	,	,	,
cord-001835-0s7ok4uw	5471	9	Bombyx	Bombyx	NNP
cord-001835-0s7ok4uw	5471	10	mori	mori	NNP
cord-001835-0s7ok4uw	5471	11	,	,	,
cord-001835-0s7ok4uw	5471	12	has	have	VBZ
cord-001835-0s7ok4uw	5471	13	holocentric	holocentric	NN
cord-001835-0s7ok4uw	5471	14	chromosomes	chromosome	NNS
cord-001835-0s7ok4uw	5471	15	since	since	IN
cord-001835-0s7ok4uw	5471	16	1970s	1970s	CD
cord-001835-0s7ok4uw	5471	17	,	,	,
cord-001835-0s7ok4uw	5471	18	none	none	NN
cord-001835-0s7ok4uw	5471	19	of	of	IN
cord-001835-0s7ok4uw	5471	20	silkworm	silkworm	NN
cord-001835-0s7ok4uw	5471	21	kinetochore	kinetochore	NN
cord-001835-0s7ok4uw	5471	22	proteins	protein	NNS
cord-001835-0s7ok4uw	5471	23	,	,	,
cord-001835-0s7ok4uw	5471	24	however	however	RB
cord-001835-0s7ok4uw	5471	25	,	,	,
cord-001835-0s7ok4uw	5471	26	have	have	VBP
cord-001835-0s7ok4uw	5471	27	been	be	VBN
cord-001835-0s7ok4uw	5471	28	identified	identify	VBN
cord-001835-0s7ok4uw	5471	29	so	so	RB
cord-001835-0s7ok4uw	5471	30	far	far	RB
cord-001835-0s7ok4uw	5471	31	.	.	.
cord-001835-0s7ok4uw	5472	1	Here	here	RB
cord-001835-0s7ok4uw	5472	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	5472	3	report	report	VBP
cord-001835-0s7ok4uw	5472	4	the	the	DT
cord-001835-0s7ok4uw	5472	5	identification	identification	NN
cord-001835-0s7ok4uw	5472	6	of	of	IN
cord-001835-0s7ok4uw	5472	7	a	a	DT
cord-001835-0s7ok4uw	5472	8	novel	novel	JJ
cord-001835-0s7ok4uw	5472	9	set	set	NN
cord-001835-0s7ok4uw	5472	10	of	of	IN
cord-001835-0s7ok4uw	5472	11	genes	gene	NNS
cord-001835-0s7ok4uw	5472	12	for	for	IN
cord-001835-0s7ok4uw	5472	13	outer	outer	JJ
cord-001835-0s7ok4uw	5472	14	kinetochore	kinetochore	NN
cord-001835-0s7ok4uw	5472	15	proteins	protein	NNS
cord-001835-0s7ok4uw	5472	16	in	in	IN
cord-001835-0s7ok4uw	5472	17	silkworm	silkworm	NN
cord-001835-0s7ok4uw	5472	18	by	by	IN
cord-001835-0s7ok4uw	5472	19	using	use	VBG
cord-001835-0s7ok4uw	5472	20	bioinformatics	bioinformatic	NNS
cord-001835-0s7ok4uw	5472	21	and	and	CC
cord-001835-0s7ok4uw	5472	22	RNA	RNA	NNP
cord-001835-0s7ok4uw	5472	23	interference	interference	NN
cord-001835-0s7ok4uw	5472	24	-	-	HYPH
cord-001835-0s7ok4uw	5472	25	based	base	VBN
cord-001835-0s7ok4uw	5472	26	screening	screening	NN
cord-001835-0s7ok4uw	5472	27	.	.	.
cord-001835-0s7ok4uw	5473	1	Under	under	IN
cord-001835-0s7ok4uw	5473	2	the	the	DT
cord-001835-0s7ok4uw	5473	3	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	5473	4	that	that	IN
cord-001835-0s7ok4uw	5473	5	depletion	depletion	NN
cord-001835-0s7ok4uw	5473	6	of	of	IN
cord-001835-0s7ok4uw	5473	7	essential	essential	JJ
cord-001835-0s7ok4uw	5473	8	kinetochore	kinetochore	NN
cord-001835-0s7ok4uw	5473	9	genes	gene	NNS
cord-001835-0s7ok4uw	5473	10	causes	cause	VBZ
cord-001835-0s7ok4uw	5473	11	cell	cell	NN
cord-001835-0s7ok4uw	5473	12	cycle	cycle	NN
cord-001835-0s7ok4uw	5473	13	arrest	arrest	NN
cord-001835-0s7ok4uw	5473	14	in	in	IN
cord-001835-0s7ok4uw	5473	15	mitosis	mitosis	NN
cord-001835-0s7ok4uw	5473	16	,	,	,
cord-001835-0s7ok4uw	5473	17	we	-PRON-	PRP
cord-001835-0s7ok4uw	5473	18	performed	perform	VBD
cord-001835-0s7ok4uw	5473	19	RNAi	RNAi	NNS
cord-001835-0s7ok4uw	5473	20	in	in	IN
cord-001835-0s7ok4uw	5473	21	the	the	DT
cord-001835-0s7ok4uw	5473	22	silkworm	silkworm	NN
cord-001835-0s7ok4uw	5473	23	cell	cell	NN
cord-001835-0s7ok4uw	5473	24	line	line	NN
cord-001835-0s7ok4uw	5473	25	,	,	,
cord-001835-0s7ok4uw	5473	26	BmN4-SID1	BmN4-SID1	NNP
cord-001835-0s7ok4uw	5473	27	,	,	,
cord-001835-0s7ok4uw	5473	28	targeting	target	VBG
cord-001835-0s7ok4uw	5473	29	a	a	DT
cord-001835-0s7ok4uw	5473	30	set	set	NN
cord-001835-0s7ok4uw	5473	31	of	of	IN
cord-001835-0s7ok4uw	5473	32	candidate	candidate	NN
cord-001835-0s7ok4uw	5473	33	genes	gene	NNS
cord-001835-0s7ok4uw	5473	34	.	.	.
cord-001835-0s7ok4uw	5474	1	Knockdown	knockdown	NN
cord-001835-0s7ok4uw	5474	2	of	of	IN
cord-001835-0s7ok4uw	5474	3	five	five	CD
cord-001835-0s7ok4uw	5474	4	genes	gene	NNS
cord-001835-0s7ok4uw	5474	5	caused	cause	VBD
cord-001835-0s7ok4uw	5474	6	significant	significant	JJ
cord-001835-0s7ok4uw	5474	7	cell	cell	NN
cord-001835-0s7ok4uw	5474	8	cycle	cycle	NN
cord-001835-0s7ok4uw	5474	9	arrest	arrest	NN
cord-001835-0s7ok4uw	5474	10	at	at	IN
cord-001835-0s7ok4uw	5474	11	the	the	DT
cord-001835-0s7ok4uw	5474	12	G2	G2	NNP
cord-001835-0s7ok4uw	5474	13	/	/	SYM
cord-001835-0s7ok4uw	5474	14	M	M	NNP
cord-001835-0s7ok4uw	5474	15	phase	phase	NN
cord-001835-0s7ok4uw	5474	16	.	.	.
cord-001835-0s7ok4uw	5475	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5475	2	also	also	RB
cord-001835-0s7ok4uw	5475	3	found	find	VBD
cord-001835-0s7ok4uw	5475	4	that	that	IN
cord-001835-0s7ok4uw	5475	5	these	these	DT
cord-001835-0s7ok4uw	5475	6	five	five	CD
cord-001835-0s7ok4uw	5475	7	proteins	protein	NNS
cord-001835-0s7ok4uw	5475	8	make	make	VBP
cord-001835-0s7ok4uw	5475	9	a	a	DT
cord-001835-0s7ok4uw	5475	10	complex	complex	NN
cord-001835-0s7ok4uw	5475	11	,	,	,
cord-001835-0s7ok4uw	5475	12	and	and	CC
cord-001835-0s7ok4uw	5475	13	that	that	IN
cord-001835-0s7ok4uw	5475	14	all	all	DT
cord-001835-0s7ok4uw	5475	15	of	of	IN
cord-001835-0s7ok4uw	5475	16	them	-PRON-	PRP
cord-001835-0s7ok4uw	5475	17	are	be	VBP
cord-001835-0s7ok4uw	5475	18	localized	localize	VBN
cord-001835-0s7ok4uw	5475	19	along	along	IN
cord-001835-0s7ok4uw	5475	20	the	the	DT
cord-001835-0s7ok4uw	5475	21	chromosome	chromosome	NN
cord-001835-0s7ok4uw	5475	22	arms	arm	NNS
cord-001835-0s7ok4uw	5475	23	,	,	,
cord-001835-0s7ok4uw	5475	24	indicating	indicate	VBG
cord-001835-0s7ok4uw	5475	25	that	that	IN
cord-001835-0s7ok4uw	5475	26	the	the	DT
cord-001835-0s7ok4uw	5475	27	silkworm	silkworm	NN
cord-001835-0s7ok4uw	5475	28	kinetochore	kinetochore	NN
cord-001835-0s7ok4uw	5475	29	extends	extend	VBZ
cord-001835-0s7ok4uw	5475	30	along	along	IN
cord-001835-0s7ok4uw	5475	31	the	the	DT
cord-001835-0s7ok4uw	5475	32	chromosome	chromosome	NN
cord-001835-0s7ok4uw	5475	33	.	.	.
cord-001835-0s7ok4uw	5476	1	Inactivation	Inactivation	NNP
cord-001835-0s7ok4uw	5476	2	of	of	IN
cord-001835-0s7ok4uw	5476	3	bine	bine	NNP
cord-001835-0s7ok4uw	5476	4	aldehyde	aldehyde	NNP
cord-001835-0s7ok4uw	5476	5	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	5476	6	from	from	IN
cord-001835-0s7ok4uw	5476	7	spinach	spinach	NN
cord-001835-0s7ok4uw	5476	8	by	by	IN
cord-001835-0s7ok4uw	5476	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5476	10	physiological	physiological	JJ
cord-001835-0s7ok4uw	5476	11	substrate	substrate	NN
cord-001835-0s7ok4uw	5476	12	bine	bine	NNP
cord-001835-0s7ok4uw	5476	13	aldehyde	aldehyde	NNP
cord-001835-0s7ok4uw	5477	1	To	to	TO
cord-001835-0s7ok4uw	5477	2	contend	contend	VB
cord-001835-0s7ok4uw	5477	3	with	with	IN
cord-001835-0s7ok4uw	5477	4	osmotic	osmotic	JJ
cord-001835-0s7ok4uw	5477	5	stress	stress	NN
cord-001835-0s7ok4uw	5477	6	caused	cause	VBN
cord-001835-0s7ok4uw	5477	7	by	by	IN
cord-001835-0s7ok4uw	5477	8	drought	drought	NN
cord-001835-0s7ok4uw	5477	9	,	,	,
cord-001835-0s7ok4uw	5477	10	salinity	salinity	NN
cord-001835-0s7ok4uw	5477	11	,	,	,
cord-001835-0s7ok4uw	5477	12	or	or	CC
cord-001835-0s7ok4uw	5477	13	low	low	JJ
cord-001835-0s7ok4uw	5477	14	temperatures	temperature	NNS
cord-001835-0s7ok4uw	5477	15	some	some	DT
cord-001835-0s7ok4uw	5477	16	plants	plant	NNS
cord-001835-0s7ok4uw	5477	17	synthesize	synthesize	VBP
cord-001835-0s7ok4uw	5477	18	the	the	DT
cord-001835-0s7ok4uw	5477	19	osmoprotectant	osmoprotectant	JJ
cord-001835-0s7ok4uw	5477	20	glycine	glycine	NN
cord-001835-0s7ok4uw	5477	21	bine	bine	NNP
cord-001835-0s7ok4uw	5477	22	(	(	-LRB-
cord-001835-0s7ok4uw	5477	23	GB	GB	NNP
cord-001835-0s7ok4uw	5477	24	)	)	-RRB-
cord-001835-0s7ok4uw	5477	25	from	from	IN
cord-001835-0s7ok4uw	5477	26	bine	bine	NNP
cord-001835-0s7ok4uw	5477	27	aldehyde	aldehyde	NNP
cord-001835-0s7ok4uw	5477	28	(	(	-LRB-
cord-001835-0s7ok4uw	5477	29	BAL	BAL	NNP
cord-001835-0s7ok4uw	5477	30	)	)	-RRB-
cord-001835-0s7ok4uw	5477	31	.	.	.
cord-001835-0s7ok4uw	5478	1	The	the	DT
cord-001835-0s7ok4uw	5478	2	last	last	JJ
cord-001835-0s7ok4uw	5478	3	step	step	NN
cord-001835-0s7ok4uw	5478	4	-	-	:
cord-001835-0s7ok4uw	5478	5	the	the	DT
cord-001835-0s7ok4uw	5478	6	irreversible	irreversible	JJ
cord-001835-0s7ok4uw	5478	7	NAD1dependent	NAD1dependent	NNP
cord-001835-0s7ok4uw	5478	8	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5478	9	of	of	IN
cord-001835-0s7ok4uw	5478	10	BAL	bal	NN
cord-001835-0s7ok4uw	5478	11	-	-	,
cord-001835-0s7ok4uw	5478	12	is	be	VBZ
cord-001835-0s7ok4uw	5478	13	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	5478	14	by	by	IN
cord-001835-0s7ok4uw	5478	15	ALDH10	ALDH10	NNP
cord-001835-0s7ok4uw	5478	16	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5478	17	that	that	WDT
cord-001835-0s7ok4uw	5478	18	exhibit	exhibit	VBP
cord-001835-0s7ok4uw	5478	19	bine	bine	NNP
cord-001835-0s7ok4uw	5478	20	aldehyde	aldehyde	NN
cord-001835-0s7ok4uw	5478	21	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	5478	22	(	(	-LRB-
cord-001835-0s7ok4uw	5478	23	BADH	BADH	NNP
cord-001835-0s7ok4uw	5478	24	)	)	-RRB-
cord-001835-0s7ok4uw	5478	25	activity	activity	NN
cord-001835-0s7ok4uw	5478	26	.	.	.
cord-001835-0s7ok4uw	5479	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5479	2	here	here	RB
cord-001835-0s7ok4uw	5479	3	report	report	VBP
cord-001835-0s7ok4uw	5479	4	that	that	IN
cord-001835-0s7ok4uw	5479	5	the	the	DT
cord-001835-0s7ok4uw	5479	6	Spinacia	Spinacia	NNP
cord-001835-0s7ok4uw	5479	7	oleracea	oleracea	NN
cord-001835-0s7ok4uw	5479	8	BADH	BADH	NNP
cord-001835-0s7ok4uw	5479	9	(	(	-LRB-
cord-001835-0s7ok4uw	5479	10	SoBADH	SoBADH	NNP
cord-001835-0s7ok4uw	5479	11	)	)	-RRB-
cord-001835-0s7ok4uw	5479	12	is	be	VBZ
cord-001835-0s7ok4uw	5479	13	reversibly	reversibly	RB
cord-001835-0s7ok4uw	5479	14	inactivated	inactivate	VBN
cord-001835-0s7ok4uw	5479	15	by	by	IN
cord-001835-0s7ok4uw	5479	16	BAL	BAL	NNP
cord-001835-0s7ok4uw	5479	17	in	in	IN
cord-001835-0s7ok4uw	5479	18	the	the	DT
cord-001835-0s7ok4uw	5479	19	absence	absence	NN
cord-001835-0s7ok4uw	5479	20	of	of	IN
cord-001835-0s7ok4uw	5479	21	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	5479	22	in	in	IN
cord-001835-0s7ok4uw	5479	23	a	a	DT
cord-001835-0s7ok4uw	5479	24	time	time	NN
cord-001835-0s7ok4uw	5479	25	-	-	HYPH
cord-001835-0s7ok4uw	5479	26	and	and	CC
cord-001835-0s7ok4uw	5479	27	concentration	concentration	NN
cord-001835-0s7ok4uw	5479	28	-	-	HYPH
cord-001835-0s7ok4uw	5479	29	dependent	dependent	JJ
cord-001835-0s7ok4uw	5479	30	mode	mode	NN
cord-001835-0s7ok4uw	5479	31	to	to	IN
cord-001835-0s7ok4uw	5479	32	approximately	approximately	RB
cord-001835-0s7ok4uw	5479	33	50	50	CD
cord-001835-0s7ok4uw	5479	34	%	%	NN
cord-001835-0s7ok4uw	5479	35	of	of	IN
cord-001835-0s7ok4uw	5479	36	the	the	DT
cord-001835-0s7ok4uw	5479	37	original	original	JJ
cord-001835-0s7ok4uw	5479	38	activity	activity	NN
cord-001835-0s7ok4uw	5479	39	.	.	.
cord-001835-0s7ok4uw	5480	1	Inactivation	inactivation	NN
cord-001835-0s7ok4uw	5480	2	kinetics	kinetic	NNS
cord-001835-0s7ok4uw	5480	3	are	be	VBP
cord-001835-0s7ok4uw	5480	4	consistent	consistent	JJ
cord-001835-0s7ok4uw	5480	5	with	with	IN
cord-001835-0s7ok4uw	5480	6	a	a	DT
cord-001835-0s7ok4uw	5480	7	partial	partial	JJ
cord-001835-0s7ok4uw	5480	8	reversible	reversible	JJ
cord-001835-0s7ok4uw	5480	9	,	,	,
cord-001835-0s7ok4uw	5480	10	two	two	CD
cord-001835-0s7ok4uw	5480	11	-	-	HYPH
cord-001835-0s7ok4uw	5480	12	steps	step	NNS
cord-001835-0s7ok4uw	5480	13	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5480	14	that	that	WDT
cord-001835-0s7ok4uw	5480	15	involves	involve	VBZ
cord-001835-0s7ok4uw	5480	16	the	the	DT
cord-001835-0s7ok4uw	5480	17	formation	formation	NN
cord-001835-0s7ok4uw	5480	18	of	of	IN
cord-001835-0s7ok4uw	5480	19	an	an	DT
cord-001835-0s7ok4uw	5480	20	active	active	JJ
cord-001835-0s7ok4uw	5480	21	non	non	JJ
cord-001835-0s7ok4uw	5480	22	-	-	JJ
cord-001835-0s7ok4uw	5480	23	covalent	covalent	JJ
cord-001835-0s7ok4uw	5480	24	enzyme•BAL	enzyme•BAL	NNP
cord-001835-0s7ok4uw	5480	25	complex	complex	NN
cord-001835-0s7ok4uw	5480	26	before	before	IN
cord-001835-0s7ok4uw	5480	27	formation	formation	NN
cord-001835-0s7ok4uw	5480	28	the	the	DT
cord-001835-0s7ok4uw	5480	29	inactive	inactive	JJ
cord-001835-0s7ok4uw	5480	30	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5480	31	-	-	HYPH
cord-001835-0s7ok4uw	5480	32	BAL	bal	NN
cord-001835-0s7ok4uw	5480	33	complex	complex	NN
cord-001835-0s7ok4uw	5480	34	.	.	.
cord-001835-0s7ok4uw	5481	1	Crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	5481	2	evidence	evidence	NN
cord-001835-0s7ok4uw	5481	3	indicates	indicate	VBZ
cord-001835-0s7ok4uw	5481	4	that	that	IN
cord-001835-0s7ok4uw	5481	5	in	in	IN
cord-001835-0s7ok4uw	5481	6	the	the	DT
cord-001835-0s7ok4uw	5481	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5481	8	previously	previously	RB
cord-001835-0s7ok4uw	5481	9	inactivated	inactivate	VBN
cord-001835-0s7ok4uw	5481	10	by	by	IN
cord-001835-0s7ok4uw	5481	11	BAL	BAL	NNP
cord-001835-0s7ok4uw	5482	1	the	the	DT
cord-001835-0s7ok4uw	5482	2	aldehyde	aldehyde	NNP
cord-001835-0s7ok4uw	5482	3	forms	form	VBZ
cord-001835-0s7ok4uw	5482	4	a	a	DT
cord-001835-0s7ok4uw	5482	5	thiohemiacetal	thiohemiacetal	NN
cord-001835-0s7ok4uw	5482	6	with	with	IN
cord-001835-0s7ok4uw	5482	7	the	the	DT
cord-001835-0s7ok4uw	5482	8	nonessential	nonessential	JJ
cord-001835-0s7ok4uw	5482	9	Cys450	cys450	XX
cord-001835-0s7ok4uw	5482	10	(	(	-LRB-
cord-001835-0s7ok4uw	5482	11	SoBADH	SoBADH	NNP
cord-001835-0s7ok4uw	5482	12	numbering	number	VBG
cord-001835-0s7ok4uw	5482	13	)	)	-RRB-
cord-001835-0s7ok4uw	5482	14	located	locate	VBN
cord-001835-0s7ok4uw	5482	15	at	at	IN
cord-001835-0s7ok4uw	5482	16	the	the	DT
cord-001835-0s7ok4uw	5482	17	aldehyde	aldehyde	NN
cord-001835-0s7ok4uw	5482	18	-	-	HYPH
cord-001835-0s7ok4uw	5482	19	entrance	entrance	NN
cord-001835-0s7ok4uw	5482	20	tunnel	tunnel	NN
cord-001835-0s7ok4uw	5482	21	,	,	,
cord-001835-0s7ok4uw	5482	22	thus	thus	RB
cord-001835-0s7ok4uw	5482	23	totally	totally	RB
cord-001835-0s7ok4uw	5482	24	blocking	block	VBG
cord-001835-0s7ok4uw	5482	25	the	the	DT
cord-001835-0s7ok4uw	5482	26	access	access	NN
cord-001835-0s7ok4uw	5482	27	to	to	IN
cord-001835-0s7ok4uw	5482	28	the	the	DT
cord-001835-0s7ok4uw	5482	29	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5482	30	cysteine	cysteine	NN
cord-001835-0s7ok4uw	5482	31	.	.	.
cord-001835-0s7ok4uw	5483	1	Accordingly	accordingly	RB
cord-001835-0s7ok4uw	5483	2	,	,	,
cord-001835-0s7ok4uw	5483	3	BAL	BAL	NNP
cord-001835-0s7ok4uw	5483	4	does	do	VBZ
cord-001835-0s7ok4uw	5483	5	not	not	RB
cord-001835-0s7ok4uw	5483	6	inactivate	inactivate	VB
cord-001835-0s7ok4uw	5483	7	the	the	DT
cord-001835-0s7ok4uw	5483	8	C450S	C450S	NNP
cord-001835-0s7ok4uw	5483	9	SoBADH	SoBADH	NNP
cord-001835-0s7ok4uw	5483	10	mutant	mutant	NN
cord-001835-0s7ok4uw	5483	11	.	.	.
cord-001835-0s7ok4uw	5484	1	Two	two	CD
cord-001835-0s7ok4uw	5484	2	crystal	crystal	NN
cord-001835-0s7ok4uw	5484	3	structures	structure	NNS
cord-001835-0s7ok4uw	5484	4	of	of	IN
cord-001835-0s7ok4uw	5484	5	the	the	DT
cord-001835-0s7ok4uw	5484	6	inactivating	inactivate	VBG
cord-001835-0s7ok4uw	5484	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5484	8	-	-	HYPH
cord-001835-0s7ok4uw	5484	9	BAL	bal	NN
cord-001835-0s7ok4uw	5484	10	complex	complex	NN
cord-001835-0s7ok4uw	5484	11	showed	show	VBD
cord-001835-0s7ok4uw	5484	12	that	that	IN
cord-001835-0s7ok4uw	5484	13	the	the	DT
cord-001835-0s7ok4uw	5484	14	trimethylammonium	trimethylammonium	NN
cord-001835-0s7ok4uw	5484	15	group	group	NN
cord-001835-0s7ok4uw	5484	16	of	of	IN
cord-001835-0s7ok4uw	5484	17	BAL	BAL	NNP
cord-001835-0s7ok4uw	5484	18	is	be	VBZ
cord-001835-0s7ok4uw	5484	19	inside	inside	IN
cord-001835-0s7ok4uw	5484	20	the	the	DT
cord-001835-0s7ok4uw	5484	21	active	active	JJ
cord-001835-0s7ok4uw	5484	22	-	-	HYPH
cord-001835-0s7ok4uw	5484	23	site	site	NN
cord-001835-0s7ok4uw	5484	24	aromatic	aromatic	JJ
cord-001835-0s7ok4uw	5484	25	box	box	NN
cord-001835-0s7ok4uw	5484	26	,	,	,
cord-001835-0s7ok4uw	5484	27	as	as	IN
cord-001835-0s7ok4uw	5484	28	in	in	IN
cord-001835-0s7ok4uw	5484	29	the	the	DT
cord-001835-0s7ok4uw	5484	30	productive	productive	JJ
cord-001835-0s7ok4uw	5484	31	way	way	NN
cord-001835-0s7ok4uw	5484	32	of	of	IN
cord-001835-0s7ok4uw	5484	33	binding	bind	VBG
cord-001835-0s7ok4uw	5484	34	.	.	.
cord-001835-0s7ok4uw	5485	1	This	this	DT
cord-001835-0s7ok4uw	5485	2	explains	explain	VBZ
cord-001835-0s7ok4uw	5485	3	why	why	WRB
cord-001835-0s7ok4uw	5485	4	the	the	DT
cord-001835-0s7ok4uw	5485	5	inactivation	inactivation	NN
cord-001835-0s7ok4uw	5485	6	of	of	IN
cord-001835-0s7ok4uw	5485	7	the	the	DT
cord-001835-0s7ok4uw	5485	8	A441I	A441I	NNP
cord-001835-0s7ok4uw	5485	9	mutant	mutant	NN
cord-001835-0s7ok4uw	5485	10	-	-	:
cord-001835-0s7ok4uw	5485	11	where	where	WRB
cord-001835-0s7ok4uw	5485	12	the	the	DT
cord-001835-0s7ok4uw	5485	13	binding	binding	NN
cord-001835-0s7ok4uw	5485	14	of	of	IN
cord-001835-0s7ok4uw	5485	15	the	the	DT
cord-001835-0s7ok4uw	5485	16	trimethylammonium	trimethylammonium	NN
cord-001835-0s7ok4uw	5485	17	group	group	NN
cord-001835-0s7ok4uw	5485	18	is	be	VBZ
cord-001835-0s7ok4uw	5485	19	hindered	hinder	VBN
cord-001835-0s7ok4uw	5485	20	-	-	HYPH
cord-001835-0s7ok4uw	5485	21	requires	require	VBZ
cord-001835-0s7ok4uw	5485	22	non	non	JJ
cord-001835-0s7ok4uw	5485	23	-	-	JJ
cord-001835-0s7ok4uw	5485	24	physiologically	physiologically	RB
cord-001835-0s7ok4uw	5485	25	high	high	JJ
cord-001835-0s7ok4uw	5485	26	BAL	bal	NN
cord-001835-0s7ok4uw	5485	27	concentrations	concentration	NNS
cord-001835-0s7ok4uw	5485	28	,	,	,
cord-001835-0s7ok4uw	5485	29	while	while	IN
cord-001835-0s7ok4uw	5485	30	the	the	DT
cord-001835-0s7ok4uw	5485	31	A441C	A441C	NNP
cord-001835-0s7ok4uw	5485	32	mutant	mutant	JJ
cord-001835-0s7ok4uw	5485	33	-	-	:
cord-001835-0s7ok4uw	5485	34	where	where	WRB
cord-001835-0s7ok4uw	5485	35	the	the	DT
cord-001835-0s7ok4uw	5485	36	binding	binding	NN
cord-001835-0s7ok4uw	5485	37	is	be	VBZ
cord-001835-0s7ok4uw	5485	38	allowed	allow	VBN
cord-001835-0s7ok4uw	5485	39	-	-	:
cord-001835-0s7ok4uw	5485	40	is	be	VBZ
cord-001835-0s7ok4uw	5485	41	inactivated	inactivate	VBN
cord-001835-0s7ok4uw	5485	42	similarly	similarly	RB
cord-001835-0s7ok4uw	5485	43	to	to	IN
cord-001835-0s7ok4uw	5485	44	the	the	DT
cord-001835-0s7ok4uw	5485	45	wildtype	wildtype	JJ
cord-001835-0s7ok4uw	5485	46	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5485	47	.	.	.
cord-001835-0s7ok4uw	5486	1	Cys-450	Cys-450	NNP
cord-001835-0s7ok4uw	5486	2	is	be	VBZ
cord-001835-0s7ok4uw	5486	3	conserved	conserve	VBN
cord-001835-0s7ok4uw	5486	4	in	in	IN
cord-001835-0s7ok4uw	5486	5	most	most	JJS
cord-001835-0s7ok4uw	5486	6	plant	plant	NN
cord-001835-0s7ok4uw	5487	1	ALDH10	ALDH10	NNP
cord-001835-0s7ok4uw	5487	2	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5487	3	of	of	IN
cord-001835-0s7ok4uw	5487	4	known	know	VBN
cord-001835-0s7ok4uw	5487	5	sequence	sequence	NN
cord-001835-0s7ok4uw	5487	6	,	,	,
cord-001835-0s7ok4uw	5487	7	and	and	CC
cord-001835-0s7ok4uw	5488	1	in	in	IN
cord-001835-0s7ok4uw	5488	2	all	all	DT
cord-001835-0s7ok4uw	5488	3	of	of	IN
cord-001835-0s7ok4uw	5488	4	them	-PRON-	PRP
cord-001835-0s7ok4uw	5488	5	with	with	IN
cord-001835-0s7ok4uw	5488	6	proven	prove	VBN
cord-001835-0s7ok4uw	5488	7	or	or	CC
cord-001835-0s7ok4uw	5488	8	predicted	predict	VBN
cord-001835-0s7ok4uw	5488	9	BADH	BADH	NNP
cord-001835-0s7ok4uw	5488	10	activity	activity	NN
cord-001835-0s7ok4uw	5488	11	.	.	.
cord-001835-0s7ok4uw	5489	1	Inactivation	inactivation	NN
cord-001835-0s7ok4uw	5489	2	by	by	IN
cord-001835-0s7ok4uw	5489	3	BAL	BAL	NNP
cord-001835-0s7ok4uw	5489	4	appears	appear	VBZ
cord-001835-0s7ok4uw	5489	5	therefore	therefore	RB
cord-001835-0s7ok4uw	5489	6	to	to	TO
cord-001835-0s7ok4uw	5489	7	be	be	VB
cord-001835-0s7ok4uw	5489	8	a	a	DT
cord-001835-0s7ok4uw	5489	9	common	common	JJ
cord-001835-0s7ok4uw	5489	10	feature	feature	NN
cord-001835-0s7ok4uw	5489	11	of	of	IN
cord-001835-0s7ok4uw	5489	12	plants	plant	NNS
cord-001835-0s7ok4uw	5489	13	BADHs	badh	NNS
cord-001835-0s7ok4uw	5489	14	.	.	.
cord-001835-0s7ok4uw	5490	1	This	this	DT
cord-001835-0s7ok4uw	5490	2	short	short	JJ
cord-001835-0s7ok4uw	5490	3	-	-	HYPH
cord-001835-0s7ok4uw	5490	4	term	term	NN
cord-001835-0s7ok4uw	5490	5	regulation	regulation	NN
cord-001835-0s7ok4uw	5490	6	may	may	MD
cord-001835-0s7ok4uw	5490	7	be	be	VB
cord-001835-0s7ok4uw	5490	8	of	of	IN
cord-001835-0s7ok4uw	5490	9	great	great	JJ
cord-001835-0s7ok4uw	5490	10	physiological	physiological	JJ
cord-001835-0s7ok4uw	5490	11	importance	importance	NN
cord-001835-0s7ok4uw	5490	12	since	since	IN
cord-001835-0s7ok4uw	5490	13	the	the	DT
cord-001835-0s7ok4uw	5490	14	irreversibility	irreversibility	NN
cord-001835-0s7ok4uw	5490	15	of	of	IN
cord-001835-0s7ok4uw	5490	16	the	the	DT
cord-001835-0s7ok4uw	5490	17	BADH	BADH	NNP
cord-001835-0s7ok4uw	5490	18	-	-	HYPH
cord-001835-0s7ok4uw	5490	19	catalyzed	catalyze	VBN
cord-001835-0s7ok4uw	5490	20	reaction	reaction	NN
cord-001835-0s7ok4uw	5490	21	would	would	MD
cord-001835-0s7ok4uw	5490	22	unbalance	unbalance	VB
cord-001835-0s7ok4uw	5490	23	the	the	DT
cord-001835-0s7ok4uw	5490	24	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	5490	25	/	/	SYM
cord-001835-0s7ok4uw	5490	26	NADH	NADH	NNP
cord-001835-0s7ok4uw	5490	27	ratio	ratio	NN
cord-001835-0s7ok4uw	5490	28	if	if	IN
cord-001835-0s7ok4uw	5490	29	the	the	DT
cord-001835-0s7ok4uw	5490	30	aldehyde	aldehyde	NN
cord-001835-0s7ok4uw	5490	31	concentrations	concentration	NNS
cord-001835-0s7ok4uw	5490	32	are	be	VBP
cord-001835-0s7ok4uw	5490	33	high	high	JJ
cord-001835-0s7ok4uw	5490	34	,	,	,
cord-001835-0s7ok4uw	5490	35	the	the	DT
cord-001835-0s7ok4uw	5490	36	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	5490	37	concentrations	concentration	NNS
cord-001835-0s7ok4uw	5490	38	low	low	JJ
cord-001835-0s7ok4uw	5490	39	and	and	CC
cord-001835-0s7ok4uw	5490	40	the	the	DT
cord-001835-0s7ok4uw	5490	41	reaction	reaction	NN
cord-001835-0s7ok4uw	5490	42	is	be	VBZ
cord-001835-0s7ok4uw	5490	43	not	not	RB
cord-001835-0s7ok4uw	5490	44	slowed	slow	VBN
cord-001835-0s7ok4uw	5490	45	down	down	RP
cord-001835-0s7ok4uw	5490	46	.	.	.
cord-001835-0s7ok4uw	5491	1	Plants	plant	NNS
cord-001835-0s7ok4uw	5491	2	BADHs	badh	NNS
cord-001835-0s7ok4uw	5491	3	are	be	VBP
cord-001835-0s7ok4uw	5491	4	prone	prone	JJ
cord-001835-0s7ok4uw	5491	5	to	to	IN
cord-001835-0s7ok4uw	5491	6	this	this	DT
cord-001835-0s7ok4uw	5491	7	situation	situation	NN
cord-001835-0s7ok4uw	5491	8	since	since	IN
cord-001835-0s7ok4uw	5491	9	they	-PRON-	PRP
cord-001835-0s7ok4uw	5491	10	work	work	VBP
cord-001835-0s7ok4uw	5491	11	under	under	IN
cord-001835-0s7ok4uw	5491	12	osmotic	osmotic	JJ
cord-001835-0s7ok4uw	5491	13	stress	stress	NN
cord-001835-0s7ok4uw	5491	14	conditions	condition	NNS
cord-001835-0s7ok4uw	5491	15	,	,	,
cord-001835-0s7ok4uw	5491	16	when	when	WRB
cord-001835-0s7ok4uw	5491	17	high	high	JJ
cord-001835-0s7ok4uw	5491	18	BAL	bal	NN
cord-001835-0s7ok4uw	5491	19	concentrations	concentration	NNS
cord-001835-0s7ok4uw	5491	20	are	be	VBP
cord-001835-0s7ok4uw	5491	21	required	require	VBN
cord-001835-0s7ok4uw	5491	22	for	for	IN
cord-001835-0s7ok4uw	5491	23	the	the	DT
cord-001835-0s7ok4uw	5491	24	synthesis	synthesis	NN
cord-001835-0s7ok4uw	5491	25	of	of	IN
cord-001835-0s7ok4uw	5491	26	high	high	JJ
cord-001835-0s7ok4uw	5491	27	levels	level	NNS
cord-001835-0s7ok4uw	5491	28	of	of	IN
cord-001835-0s7ok4uw	5491	29	the	the	DT
cord-001835-0s7ok4uw	5491	30	osmoprotectant	osmoprotectant	JJ
cord-001835-0s7ok4uw	5491	31	GB	GB	NNP
cord-001835-0s7ok4uw	5491	32	.	.	.
cord-001835-0s7ok4uw	5492	1	The	the	DT
cord-001835-0s7ok4uw	5492	2	partial	partial	JJ
cord-001835-0s7ok4uw	5492	3	nature	nature	NN
cord-001835-0s7ok4uw	5492	4	of	of	IN
cord-001835-0s7ok4uw	5492	5	The	the	DT
cord-001835-0s7ok4uw	5492	6	decamer	decamer	NNP
cord-001835-0s7ok4uw	5492	7	possesses	possess	VBZ
cord-001835-0s7ok4uw	5492	8	a	a	DT
cord-001835-0s7ok4uw	5492	9	donut	donut	NN
cord-001835-0s7ok4uw	5492	10	shaped	shape	VBN
cord-001835-0s7ok4uw	5492	11	structure	structure	NN
cord-001835-0s7ok4uw	5492	12	with	with	IN
cord-001835-0s7ok4uw	5492	13	10	10	CD
cord-001835-0s7ok4uw	5492	14	calcium	calcium	NN
cord-001835-0s7ok4uw	5492	15	ions	ion	NNS
cord-001835-0s7ok4uw	5492	16	on	on	IN
cord-001835-0s7ok4uw	5492	17	the	the	DT
cord-001835-0s7ok4uw	5492	18	surface	surface	NN
cord-001835-0s7ok4uw	5492	19	available	available	JJ
cord-001835-0s7ok4uw	5492	20	for	for	IN
cord-001835-0s7ok4uw	5492	21	interactions	interaction	NNS
cord-001835-0s7ok4uw	5492	22	with	with	IN
cord-001835-0s7ok4uw	5492	23	carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	5492	24	molecules	molecule	NNS
cord-001835-0s7ok4uw	5492	25	.	.	.
cord-001835-0s7ok4uw	5493	1	Binding	bind	VBG
cord-001835-0s7ok4uw	5493	2	specificity	specificity	NN
cord-001835-0s7ok4uw	5493	3	was	be	VBD
cord-001835-0s7ok4uw	5493	4	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	5493	5	for	for	IN
cord-001835-0s7ok4uw	5493	6	20	20	CD
cord-001835-0s7ok4uw	5493	7	carbohydrates	carbohydrate	NNS
cord-001835-0s7ok4uw	5493	8	using	use	VBG
cord-001835-0s7ok4uw	5493	9	differential	differential	JJ
cord-001835-0s7ok4uw	5493	10	scanning	scanning	NN
cord-001835-0s7ok4uw	5493	11	fluorimetry	fluorimetry	NN
cord-001835-0s7ok4uw	5493	12	(	(	-LRB-
cord-001835-0s7ok4uw	5493	13	DSF	DSF	NNP
cord-001835-0s7ok4uw	5493	14	)	)	-RRB-
cord-001835-0s7ok4uw	5493	15	that	that	WDT
cord-001835-0s7ok4uw	5493	16	showed	show	VBD
cord-001835-0s7ok4uw	5493	17	BJcuL	BJcuL	NNP
cord-001835-0s7ok4uw	5493	18	interacts	interact	VBZ
cord-001835-0s7ok4uw	5493	19	with	with	IN
cord-001835-0s7ok4uw	5493	20	galactose	galactose	NN
cord-001835-0s7ok4uw	5493	21	and	and	CC
cord-001835-0s7ok4uw	5493	22	lactose	lactose	NN
cord-001835-0s7ok4uw	5493	23	but	but	CC
cord-001835-0s7ok4uw	5493	24	less	less	JJR
cord-001835-0s7ok4uw	5493	25	with	with	IN
cord-001835-0s7ok4uw	5493	26	glucose	glucose	NN
cord-001835-0s7ok4uw	5493	27	and	and	CC
cord-001835-0s7ok4uw	5493	28	sacarose	sacarose	NN
cord-001835-0s7ok4uw	5493	29	.	.	.
cord-001835-0s7ok4uw	5494	1	Surprisingly	surprisingly	RB
cord-001835-0s7ok4uw	5494	2	,	,	,
cord-001835-0s7ok4uw	5494	3	high	high	JJ
cord-001835-0s7ok4uw	5494	4	levels	level	NNS
cord-001835-0s7ok4uw	5494	5	of	of	IN
cord-001835-0s7ok4uw	5494	6	thermostabilization	thermostabilization	NN
cord-001835-0s7ok4uw	5494	7	of	of	IN
cord-001835-0s7ok4uw	5494	8	BJcuL	BJcuL	NNP
cord-001835-0s7ok4uw	5494	9	was	be	VBD
cord-001835-0s7ok4uw	5494	10	achieved	achieve	VBN
cord-001835-0s7ok4uw	5494	11	with	with	IN
cord-001835-0s7ok4uw	5494	12	the	the	DT
cord-001835-0s7ok4uw	5494	13	antibiotic	antibiotic	JJ
cord-001835-0s7ok4uw	5494	14	aminoglycosides	aminoglycosides	NNP
cord-001835-0s7ok4uw	5494	15	geneticin	geneticin	NNP
cord-001835-0s7ok4uw	5494	16	(	(	-LRB-
cord-001835-0s7ok4uw	5494	17	G418	G418	NNP
cord-001835-0s7ok4uw	5494	18	)	)	-RRB-
cord-001835-0s7ok4uw	5494	19	and	and	CC
cord-001835-0s7ok4uw	5494	20	gentamicin	gentamicin	NNS
cord-001835-0s7ok4uw	5494	21	in	in	IN
cord-001835-0s7ok4uw	5494	22	a	a	DT
cord-001835-0s7ok4uw	5494	23	calcium	calcium	NN
cord-001835-0s7ok4uw	5494	24	concentration	concentration	NN
cord-001835-0s7ok4uw	5494	25	dependent	dependent	JJ
cord-001835-0s7ok4uw	5494	26	manner	manner	NN
cord-001835-0s7ok4uw	5494	27	,	,	,
cord-001835-0s7ok4uw	5494	28	but	but	CC
cord-001835-0s7ok4uw	5494	29	not	not	RB
cord-001835-0s7ok4uw	5494	30	kanamycin	kanamycin	NNP
cord-001835-0s7ok4uw	5494	31	.	.	.
cord-001835-0s7ok4uw	5495	1	Intriguingly	intriguingly	RB
cord-001835-0s7ok4uw	5495	2	,	,	,
cord-001835-0s7ok4uw	5495	3	while	while	IN
cord-001835-0s7ok4uw	5495	4	lactose	lactose	NN
cord-001835-0s7ok4uw	5495	5	and	and	CC
cord-001835-0s7ok4uw	5495	6	galactose	galactose	NN
cord-001835-0s7ok4uw	5495	7	inhibited	inhibit	VBN
cord-001835-0s7ok4uw	5495	8	erythrocyte	erythrocyte	NN
cord-001835-0s7ok4uw	5495	9	agglutination	agglutination	NN
cord-001835-0s7ok4uw	5495	10	by	by	IN
cord-001835-0s7ok4uw	5495	11	BJcuL	BJcuL	NNP
cord-001835-0s7ok4uw	5495	12	,	,	,
cord-001835-0s7ok4uw	5495	13	G418	G418	NNPS
cord-001835-0s7ok4uw	5495	14	and	and	CC
cord-001835-0s7ok4uw	5495	15	gentamicin	gentamicin	NNS
cord-001835-0s7ok4uw	5495	16	did	do	VBD
cord-001835-0s7ok4uw	5495	17	not	not	RB
cord-001835-0s7ok4uw	5495	18	affect	affect	VB
cord-001835-0s7ok4uw	5495	19	hemagglutination	hemagglutination	NN
cord-001835-0s7ok4uw	5495	20	implying	imply	VBG
cord-001835-0s7ok4uw	5495	21	a	a	DT
cord-001835-0s7ok4uw	5495	22	second	second	JJ
cord-001835-0s7ok4uw	5495	23	site	site	NN
cord-001835-0s7ok4uw	5495	24	of	of	IN
cord-001835-0s7ok4uw	5495	25	binding	bind	VBG
cord-001835-0s7ok4uw	5495	26	.	.	.
cord-001835-0s7ok4uw	5496	1	DSF	DSF	NNP
cord-001835-0s7ok4uw	5496	2	analysis	analysis	NN
cord-001835-0s7ok4uw	5496	3	also	also	RB
cord-001835-0s7ok4uw	5496	4	suggested	suggest	VBD
cord-001835-0s7ok4uw	5496	5	the	the	DT
cord-001835-0s7ok4uw	5496	6	presence	presence	NN
cord-001835-0s7ok4uw	5496	7	of	of	IN
cord-001835-0s7ok4uw	5496	8	a	a	DT
cord-001835-0s7ok4uw	5496	9	second	second	JJ
cord-001835-0s7ok4uw	5496	10	binding	binding	NN
cord-001835-0s7ok4uw	5496	11	site	site	NN
cord-001835-0s7ok4uw	5496	12	for	for	IN
cord-001835-0s7ok4uw	5496	13	the	the	DT
cord-001835-0s7ok4uw	5496	14	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	5496	15	and	and	CC
cord-001835-0s7ok4uw	5496	16	crystallization	crystallization	NN
cord-001835-0s7ok4uw	5496	17	of	of	IN
cord-001835-0s7ok4uw	5496	18	the	the	DT
cord-001835-0s7ok4uw	5496	19	complexes	complex	NNS
cord-001835-0s7ok4uw	5496	20	are	be	VBP
cord-001835-0s7ok4uw	5496	21	in	in	IN
cord-001835-0s7ok4uw	5496	22	progress	progress	NN
cord-001835-0s7ok4uw	5496	23	in	in	IN
cord-001835-0s7ok4uw	5496	24	order	order	NN
cord-001835-0s7ok4uw	5496	25	to	to	TO
cord-001835-0s7ok4uw	5496	26	understand	understand	VB
cord-001835-0s7ok4uw	5496	27	fully	fully	RB
cord-001835-0s7ok4uw	5496	28	this	this	DT
cord-001835-0s7ok4uw	5496	29	new	new	JJ
cord-001835-0s7ok4uw	5496	30	binding	binding	NN
cord-001835-0s7ok4uw	5496	31	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5496	32	of	of	IN
cord-001835-0s7ok4uw	5496	33	C	c	NN
cord-001835-0s7ok4uw	5496	34	-	-	HYPH
cord-001835-0s7ok4uw	5496	35	type	type	NN
cord-001835-0s7ok4uw	5496	36	lectin	lectin	NN
cord-001835-0s7ok4uw	5496	37	with	with	IN
cord-001835-0s7ok4uw	5496	38	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	5496	39	.	.	.
cord-001835-0s7ok4uw	5497	1	Ab	ab	NN
cord-001835-0s7ok4uw	5497	2	initio	initio	JJ
cord-001835-0s7ok4uw	5497	3	modelling	modelling	NN
cord-001835-0s7ok4uw	5497	4	of	of	IN
cord-001835-0s7ok4uw	5497	5	structurally	structurally	RB
cord-001835-0s7ok4uw	5497	6	uncharacterised	uncharacterise	VBN
cord-001835-0s7ok4uw	5497	7	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5497	8	peptides	peptide	NNS
cord-001835-0s7ok4uw	5497	9	Mara	Mara	NNP
cord-001835-0s7ok4uw	5497	10	Kozic	Kozic	NNP
cord-001835-0s7ok4uw	5497	11	1	1	CD
cord-001835-0s7ok4uw	5497	12	1	1	CD
cord-001835-0s7ok4uw	5497	13	Institute	Institute	NNP
cord-001835-0s7ok4uw	5497	14	of	of	IN
cord-001835-0s7ok4uw	5497	15	Integrative	Integrative	NNP
cord-001835-0s7ok4uw	5497	16	Biology	Biology	NNP
cord-001835-0s7ok4uw	5497	17	,	,	,
cord-001835-0s7ok4uw	5498	1	University	University	NNP
cord-001835-0s7ok4uw	5498	2	of	of	IN
cord-001835-0s7ok4uw	5498	3	Liverpool	Liverpool	NNP
cord-001835-0s7ok4uw	5498	4	Ab	Ab	NNP
cord-001835-0s7ok4uw	5498	5	initio	initio	NN
cord-001835-0s7ok4uw	5498	6	modelling	modelling	NN
cord-001835-0s7ok4uw	5498	7	of	of	IN
cord-001835-0s7ok4uw	5498	8	structurally	structurally	RB
cord-001835-0s7ok4uw	5498	9	uncharacterised	uncharacterise	VBN
cord-001835-0s7ok4uw	5498	10	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5498	11	peptides	peptide	NNS
cord-001835-0s7ok4uw	5499	1	Mara	Mara	NNP
cord-001835-0s7ok4uw	5499	2	Kozic	Kozic	NNP
cord-001835-0s7ok4uw	5499	3	1	1	CD
cord-001835-0s7ok4uw	5499	4	*	*	SYM
cord-001835-0s7ok4uw	5499	5	1	1	CD
cord-001835-0s7ok4uw	5499	6	Institute	Institute	NNP
cord-001835-0s7ok4uw	5499	7	of	of	IN
cord-001835-0s7ok4uw	5499	8	Integrative	Integrative	NNP
cord-001835-0s7ok4uw	5499	9	Biology	Biology	NNP
cord-001835-0s7ok4uw	5499	10	,	,	,
cord-001835-0s7ok4uw	5499	11	Biosciences	Biosciences	NNP
cord-001835-0s7ok4uw	5499	12	Building	Building	NNP
cord-001835-0s7ok4uw	5499	13	,	,	,
cord-001835-0s7ok4uw	5499	14	University	University	NNP
cord-001835-0s7ok4uw	5499	15	of	of	IN
cord-001835-0s7ok4uw	5499	16	Liverpool	Liverpool	NNP
cord-001835-0s7ok4uw	5499	17	,	,	,
cord-001835-0s7ok4uw	5499	18	Crown	Crown	NNP
cord-001835-0s7ok4uw	5499	19	Street	Street	NNP
cord-001835-0s7ok4uw	5499	20	,	,	,
cord-001835-0s7ok4uw	5499	21	Liverpool	Liverpool	NNP
cord-001835-0s7ok4uw	5499	22	L69	L69	NNP
cord-001835-0s7ok4uw	5499	23	7ZB	7ZB	NNP
cord-001835-0s7ok4uw	5499	24	,	,	,
cord-001835-0s7ok4uw	5499	25	United	United	NNP
cord-001835-0s7ok4uw	5499	26	Kingdom	Kingdom	NNP
cord-001835-0s7ok4uw	5500	1	*	*	NFP
cord-001835-0s7ok4uw	5500	2	Mara.Kozic@liverpool.ac.uk	Mara.Kozic@liverpool.ac.uk	NNP
cord-001835-0s7ok4uw	5500	3	Antimicrobial	Antimicrobial	NNP
cord-001835-0s7ok4uw	5500	4	resistance	resistance	NN
cord-001835-0s7ok4uw	5500	5	within	within	IN
cord-001835-0s7ok4uw	5500	6	a	a	DT
cord-001835-0s7ok4uw	5500	7	wide	wide	JJ
cord-001835-0s7ok4uw	5500	8	range	range	NN
cord-001835-0s7ok4uw	5500	9	of	of	IN
cord-001835-0s7ok4uw	5500	10	infectious	infectious	JJ
cord-001835-0s7ok4uw	5500	11	agents	agent	NNS
cord-001835-0s7ok4uw	5500	12	is	be	VBZ
cord-001835-0s7ok4uw	5500	13	a	a	DT
cord-001835-0s7ok4uw	5500	14	severe	severe	JJ
cord-001835-0s7ok4uw	5500	15	and	and	CC
cord-001835-0s7ok4uw	5500	16	growing	grow	VBG
cord-001835-0s7ok4uw	5500	17	public	public	JJ
cord-001835-0s7ok4uw	5500	18	health	health	NN
cord-001835-0s7ok4uw	5500	19	threat	threat	NN
cord-001835-0s7ok4uw	5500	20	.	.	.
cord-001835-0s7ok4uw	5501	1	Antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5501	2	peptides	peptide	NNS
cord-001835-0s7ok4uw	5501	3	(	(	-LRB-
cord-001835-0s7ok4uw	5501	4	AMPs	amp	NNS
cord-001835-0s7ok4uw	5501	5	)	)	-RRB-
cord-001835-0s7ok4uw	5501	6	are	be	VBP
cord-001835-0s7ok4uw	5501	7	among	among	IN
cord-001835-0s7ok4uw	5501	8	the	the	DT
cord-001835-0s7ok4uw	5501	9	leading	lead	VBG
cord-001835-0s7ok4uw	5501	10	alternatives	alternative	NNS
cord-001835-0s7ok4uw	5501	11	to	to	IN
cord-001835-0s7ok4uw	5501	12	current	current	JJ
cord-001835-0s7ok4uw	5501	13	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	5501	14	,	,	,
cord-001835-0s7ok4uw	5501	15	exhibiting	exhibit	VBG
cord-001835-0s7ok4uw	5501	16	broad	broad	JJ
cord-001835-0s7ok4uw	5501	17	spectrum	spectrum	NN
cord-001835-0s7ok4uw	5501	18	activity	activity	NN
cord-001835-0s7ok4uw	5501	19	.	.	.
cord-001835-0s7ok4uw	5502	1	An	an	DT
cord-001835-0s7ok4uw	5502	2	understanding	understanding	NN
cord-001835-0s7ok4uw	5502	3	of	of	IN
cord-001835-0s7ok4uw	5502	4	the	the	DT
cord-001835-0s7ok4uw	5502	5	structure	structure	NN
cord-001835-0s7ok4uw	5502	6	of	of	IN
cord-001835-0s7ok4uw	5502	7	a	a	DT
cord-001835-0s7ok4uw	5502	8	protein	protein	NN
cord-001835-0s7ok4uw	5502	9	can	can	MD
cord-001835-0s7ok4uw	5502	10	lead	lead	VB
cord-001835-0s7ok4uw	5502	11	us	-PRON-	PRP
cord-001835-0s7ok4uw	5502	12	to	to	IN
cord-001835-0s7ok4uw	5502	13	a	a	DT
cord-001835-0s7ok4uw	5502	14	much	much	RB
cord-001835-0s7ok4uw	5502	15	improved	improved	JJ
cord-001835-0s7ok4uw	5502	16	picture	picture	NN
cord-001835-0s7ok4uw	5502	17	of	of	IN
cord-001835-0s7ok4uw	5502	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5502	19	molecular	molecular	JJ
cord-001835-0s7ok4uw	5502	20	function	function	NN
cord-001835-0s7ok4uw	5502	21	.	.	.
cord-001835-0s7ok4uw	5503	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	5503	2	,	,	,
cord-001835-0s7ok4uw	5503	3	an	an	DT
cord-001835-0s7ok4uw	5503	4	improved	improved	JJ
cord-001835-0s7ok4uw	5503	5	understanding	understanding	NN
cord-001835-0s7ok4uw	5503	6	of	of	IN
cord-001835-0s7ok4uw	5503	7	structure	structure	NN
cord-001835-0s7ok4uw	5503	8	-	-	HYPH
cord-001835-0s7ok4uw	5503	9	function	function	NN
cord-001835-0s7ok4uw	5503	10	relationships	relationship	NNS
cord-001835-0s7ok4uw	5503	11	facilitates	facilitate	VBZ
cord-001835-0s7ok4uw	5503	12	protein	protein	NN
cord-001835-0s7ok4uw	5503	13	design	design	NN
cord-001835-0s7ok4uw	5503	14	efforts	effort	NNS
cord-001835-0s7ok4uw	5503	15	to	to	TO
cord-001835-0s7ok4uw	5503	16	enhance	enhance	VB
cord-001835-0s7ok4uw	5503	17	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5503	18	activity	activity	NN
cord-001835-0s7ok4uw	5503	19	.	.	.
cord-001835-0s7ok4uw	5504	1	Currently	currently	RB
cord-001835-0s7ok4uw	5504	2	,	,	,
cord-001835-0s7ok4uw	5504	3	the	the	DT
cord-001835-0s7ok4uw	5504	4	3D	3d	JJ
cord-001835-0s7ok4uw	5504	5	structures	structure	NNS
cord-001835-0s7ok4uw	5504	6	of	of	IN
cord-001835-0s7ok4uw	5504	7	many	many	JJ
cord-001835-0s7ok4uw	5504	8	known	know	VBN
cord-001835-0s7ok4uw	5504	9	AMPs	amp	NNS
cord-001835-0s7ok4uw	5504	10	are	be	VBP
cord-001835-0s7ok4uw	5504	11	unknown	unknown	JJ
cord-001835-0s7ok4uw	5504	12	.	.	.
cord-001835-0s7ok4uw	5505	1	To	to	TO
cord-001835-0s7ok4uw	5505	2	improve	improve	VB
cord-001835-0s7ok4uw	5505	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5505	4	understanding	understanding	NN
cord-001835-0s7ok4uw	5505	5	of	of	IN
cord-001835-0s7ok4uw	5505	6	the	the	DT
cord-001835-0s7ok4uw	5505	7	AMP	AMP	NNP
cord-001835-0s7ok4uw	5505	8	structural	structural	JJ
cord-001835-0s7ok4uw	5505	9	universe	universe	NN
cord-001835-0s7ok4uw	5505	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	5505	11	have	have	VBP
cord-001835-0s7ok4uw	5505	12	carried	carry	VBN
cord-001835-0s7ok4uw	5505	13	out	out	RP
cord-001835-0s7ok4uw	5505	14	large	large	JJ
cord-001835-0s7ok4uw	5505	15	scale	scale	NN
cord-001835-0s7ok4uw	5505	16	ab	ab	FW
cord-001835-0s7ok4uw	5505	17	initio	initio	JJ
cord-001835-0s7ok4uw	5505	18	3D	3d	JJ
cord-001835-0s7ok4uw	5505	19	modelling	modelling	NN
cord-001835-0s7ok4uw	5505	20	of	of	IN
cord-001835-0s7ok4uw	5505	21	structurally	structurally	RB
cord-001835-0s7ok4uw	5505	22	uncharacterised	uncharacterise	VBN
cord-001835-0s7ok4uw	5505	23	AMPs	amp	NNS
cord-001835-0s7ok4uw	5505	24	.	.	.
cord-001835-0s7ok4uw	5506	1	Such	such	JJ
cord-001835-0s7ok4uw	5506	2	ab	ab	NN
cord-001835-0s7ok4uw	5506	3	initio	initio	JJ
cord-001835-0s7ok4uw	5506	4	modelling	modelling	NN
cord-001835-0s7ok4uw	5506	5	is	be	VBZ
cord-001835-0s7ok4uw	5506	6	facilitated	facilitate	VBN
cord-001835-0s7ok4uw	5506	7	by	by	IN
cord-001835-0s7ok4uw	5506	8	the	the	DT
cord-001835-0s7ok4uw	5506	9	typical	typical	JJ
cord-001835-0s7ok4uw	5506	10	small	small	JJ
cord-001835-0s7ok4uw	5506	11	size	size	NN
cord-001835-0s7ok4uw	5506	12	of	of	IN
cord-001835-0s7ok4uw	5506	13	AMPs	amp	NNS
cord-001835-0s7ok4uw	5506	14	as	as	RB
cord-001835-0s7ok4uw	5506	15	well	well	RB
cord-001835-0s7ok4uw	5506	16	as	as	IN
cord-001835-0s7ok4uw	5506	17	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5506	18	tendency	tendency	NN
cord-001835-0s7ok4uw	5506	19	to	to	TO
cord-001835-0s7ok4uw	5506	20	contain	contain	VB
cord-001835-0s7ok4uw	5506	21	disulphide	disulphide	JJ
cord-001835-0s7ok4uw	5506	22	bonds	bond	NNS
cord-001835-0s7ok4uw	5506	23	,	,	,
cord-001835-0s7ok4uw	5506	24	these	these	DT
cord-001835-0s7ok4uw	5506	25	providing	provide	VBG
cord-001835-0s7ok4uw	5506	26	valuable	valuable	JJ
cord-001835-0s7ok4uw	5506	27	additional	additional	JJ
cord-001835-0s7ok4uw	5506	28	information	information	NN
cord-001835-0s7ok4uw	5506	29	to	to	IN
cord-001835-0s7ok4uw	5506	30	simulations	simulation	NNS
cord-001835-0s7ok4uw	5506	31	.	.	.
cord-001835-0s7ok4uw	5507	1	Preliminary	preliminary	JJ
cord-001835-0s7ok4uw	5507	2	results	result	NNS
cord-001835-0s7ok4uw	5507	3	reveal	reveal	VBP
cord-001835-0s7ok4uw	5507	4	unexpected	unexpected	JJ
cord-001835-0s7ok4uw	5507	5	similarities	similarity	NNS
cord-001835-0s7ok4uw	5507	6	between	between	IN
cord-001835-0s7ok4uw	5507	7	the	the	DT
cord-001835-0s7ok4uw	5507	8	predicted	predict	VBN
cord-001835-0s7ok4uw	5507	9	folds	fold	NNS
cord-001835-0s7ok4uw	5507	10	of	of	IN
cord-001835-0s7ok4uw	5507	11	the	the	DT
cord-001835-0s7ok4uw	5507	12	modelled	model	VBN
cord-001835-0s7ok4uw	5507	13	sequences	sequence	NNS
cord-001835-0s7ok4uw	5507	14	and	and	CC
cord-001835-0s7ok4uw	5507	15	structures	structure	NNS
cord-001835-0s7ok4uw	5507	16	of	of	IN
cord-001835-0s7ok4uw	5507	17	well	well	RB
cord-001835-0s7ok4uw	5507	18	-	-	HYPH
cord-001835-0s7ok4uw	5507	19	characterised	characterise	VBN
cord-001835-0s7ok4uw	5507	20	AMPs	amp	NNS
cord-001835-0s7ok4uw	5507	21	.	.	.
cord-001835-0s7ok4uw	5508	1	For	for	IN
cord-001835-0s7ok4uw	5508	2	example	example	NN
cord-001835-0s7ok4uw	5508	3	,	,	,
cord-001835-0s7ok4uw	5508	4	Lacticin	Lacticin	NNP
cord-001835-0s7ok4uw	5508	5	Q	Q	NNP
cord-001835-0s7ok4uw	5508	6	was	be	VBD
cord-001835-0s7ok4uw	5508	7	revealed	reveal	VBN
cord-001835-0s7ok4uw	5508	8	to	to	TO
cord-001835-0s7ok4uw	5508	9	contain	contain	VB
cord-001835-0s7ok4uw	5508	10	a	a	DT
cord-001835-0s7ok4uw	5508	11	helical	helical	JJ
cord-001835-0s7ok4uw	5508	12	bundle	bundle	NN
cord-001835-0s7ok4uw	5508	13	fold	fold	NN
cord-001835-0s7ok4uw	5508	14	that	that	WDT
cord-001835-0s7ok4uw	5508	15	bears	bear	VBZ
cord-001835-0s7ok4uw	5508	16	a	a	DT
cord-001835-0s7ok4uw	5508	17	striking	striking	JJ
cord-001835-0s7ok4uw	5508	18	resemblance	resemblance	NN
cord-001835-0s7ok4uw	5508	19	to	to	IN
cord-001835-0s7ok4uw	5508	20	Enterocin	Enterocin	NNP
cord-001835-0s7ok4uw	5508	21	7A.	7a.	CD
cord-001835-0s7ok4uw	5509	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5509	2	also	also	RB
cord-001835-0s7ok4uw	5509	3	found	find	VBD
cord-001835-0s7ok4uw	5509	4	a	a	DT
cord-001835-0s7ok4uw	5509	5	remarkable	remarkable	JJ
cord-001835-0s7ok4uw	5509	6	similarity	similarity	NN
cord-001835-0s7ok4uw	5509	7	between	between	IN
cord-001835-0s7ok4uw	5509	8	the	the	DT
cord-001835-0s7ok4uw	5509	9	predicted	predict	VBN
cord-001835-0s7ok4uw	5509	10	structure	structure	NN
cord-001835-0s7ok4uw	5509	11	of	of	IN
cord-001835-0s7ok4uw	5509	12	Silkworm	Silkworm	NNP
cord-001835-0s7ok4uw	5509	13	001	001	CD
cord-001835-0s7ok4uw	5509	14	peptide	peptide	NN
cord-001835-0s7ok4uw	5509	15	and	and	CC
cord-001835-0s7ok4uw	5509	16	b	b	NN
cord-001835-0s7ok4uw	5509	17	-	-	HYPH
cord-001835-0s7ok4uw	5509	18	hairpin	hairpin	NN
cord-001835-0s7ok4uw	5509	19	AMPs	amp	NNS
cord-001835-0s7ok4uw	5509	20	such	such	JJ
cord-001835-0s7ok4uw	5509	21	as	as	IN
cord-001835-0s7ok4uw	5509	22	Tachyplesin	Tachyplesin	NNP
cord-001835-0s7ok4uw	5509	23	I.	I.	NNP
cord-001835-0s7ok4uw	5510	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	5510	2	results	result	NNS
cord-001835-0s7ok4uw	5510	3	improve	improve	VBP
cord-001835-0s7ok4uw	5510	4	the	the	DT
cord-001835-0s7ok4uw	5510	5	understanding	understanding	NN
cord-001835-0s7ok4uw	5510	6	of	of	IN
cord-001835-0s7ok4uw	5510	7	the	the	DT
cord-001835-0s7ok4uw	5510	8	structure	structure	NN
cord-001835-0s7ok4uw	5510	9	-	-	HYPH
cord-001835-0s7ok4uw	5510	10	function	function	NN
cord-001835-0s7ok4uw	5510	11	relationship	relationship	NN
cord-001835-0s7ok4uw	5510	12	of	of	IN
cord-001835-0s7ok4uw	5510	13	AMPs	amp	NNS
cord-001835-0s7ok4uw	5510	14	.	.	.
cord-001835-0s7ok4uw	5511	1	Surface	surface	NN
cord-001835-0s7ok4uw	5511	2	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5511	3	-	-	HYPH
cord-001835-0s7ok4uw	5511	4	propensity	propensity	NN
cord-001835-0s7ok4uw	5511	5	as	as	IN
cord-001835-0s7ok4uw	5511	6	a	a	DT
cord-001835-0s7ok4uw	5511	7	constraint	constraint	NN
cord-001835-0s7ok4uw	5511	8	on	on	IN
cord-001835-0s7ok4uw	5511	9	globular	globular	JJ
cord-001835-0s7ok4uw	5511	10	proteins	protein	NNS
cord-001835-0s7ok4uw	5511	11	evolution	evolution	NN
cord-001835-0s7ok4uw	5511	12	Susanna	Susanna	NNP
cord-001835-0s7ok4uw	5511	13	Navarro	Navarro	NNP
cord-001835-0s7ok4uw	5511	14	1	1	CD
cord-001835-0s7ok4uw	5511	15	,	,	,
cord-001835-0s7ok4uw	5511	16	Marta	Marta	NNP
cord-001835-0s7ok4uw	5511	17	Diaz	Diaz	NNP
cord-001835-0s7ok4uw	5511	18	2	2	CD
cord-001835-0s7ok4uw	5511	19	,	,	,
cord-001835-0s7ok4uw	5511	20	Pablo	Pablo	NNP
cord-001835-0s7ok4uw	5511	21	Gallego	Gallego	NNP
cord-001835-0s7ok4uw	5511	22	2	2	CD
cord-001835-0s7ok4uw	5511	23	,	,	,
cord-001835-0s7ok4uw	5511	24	David	David	NNP
cord-001835-0s7ok4uw	5511	25	Reverter	Reverter	NNP
cord-001835-0s7ok4uw	5511	26	2	2	CD
cord-001835-0s7ok4uw	5511	27	,	,	,
cord-001835-0s7ok4uw	5511	28	Salvador	Salvador	NNP
cord-001835-0s7ok4uw	5511	29	Ventura	Ventura	NNP
cord-001835-0s7ok4uw	5511	30	1	1	CD
cord-001835-0s7ok4uw	5511	31	1	1	CD
cord-001835-0s7ok4uw	5511	32	Institut	Institut	NNP
cord-001835-0s7ok4uw	5511	33	de	de	IN
cord-001835-0s7ok4uw	5511	34	Biotecnologia	Biotecnologia	NNP
cord-001835-0s7ok4uw	5512	1	i	i	PRP
cord-001835-0s7ok4uw	5512	2	Biomedicina	Biomedicina	NNP
cord-001835-0s7ok4uw	5512	3	and	and	CC
cord-001835-0s7ok4uw	5512	4	Departament	Departament	NNP
cord-001835-0s7ok4uw	5512	5	de	de	NNP
cord-001835-0s7ok4uw	5512	6	Bioquimica	Bioquimica	NNP
cord-001835-0s7ok4uw	5513	1	i	i	NNP
cord-001835-0s7ok4uw	5513	2	Biologia	Biologia	NNP
cord-001835-0s7ok4uw	5513	3	,	,	,
cord-001835-0s7ok4uw	5513	4	2	2	CD
cord-001835-0s7ok4uw	5513	5	Institut	Institut	NNP
cord-001835-0s7ok4uw	5513	6	de	de	IN
cord-001835-0s7ok4uw	5513	7	Biotecnologia	Biotecnologia	NNP
cord-001835-0s7ok4uw	5514	1	i	i	PRP
cord-001835-0s7ok4uw	5514	2	Biomedicina	Biomedicina	NNP
cord-001835-0s7ok4uw	5514	3	,	,	,
cord-001835-0s7ok4uw	5514	4	Universitat	Universitat	NNP
cord-001835-0s7ok4uw	5514	5	Aut	Aut	NNP
cord-001835-0s7ok4uw	5514	6	onoma	onoma	NN
cord-001835-0s7ok4uw	5514	7	de	de	FW
cord-001835-0s7ok4uw	5514	8	Barcelona	Barcelona	NNP
cord-001835-0s7ok4uw	5515	1	In	in	IN
cord-001835-0s7ok4uw	5515	2	living	living	NN
cord-001835-0s7ok4uw	5515	3	cells	cell	NNS
cord-001835-0s7ok4uw	5515	4	,	,	,
cord-001835-0s7ok4uw	5515	5	functional	functional	JJ
cord-001835-0s7ok4uw	5515	6	protein	protein	NN
cord-001835-0s7ok4uw	5515	7	-	-	HYPH
cord-001835-0s7ok4uw	5515	8	protein	protein	NN
cord-001835-0s7ok4uw	5515	9	interactions	interaction	NNS
cord-001835-0s7ok4uw	5515	10	compete	compete	VBP
cord-001835-0s7ok4uw	5515	11	with	with	IN
cord-001835-0s7ok4uw	5515	12	a	a	DT
cord-001835-0s7ok4uw	5515	13	much	much	RB
cord-001835-0s7ok4uw	5515	14	larger	large	JJR
cord-001835-0s7ok4uw	5515	15	number	number	NN
cord-001835-0s7ok4uw	5515	16	of	of	IN
cord-001835-0s7ok4uw	5515	17	nonfunctional	nonfunctional	JJ
cord-001835-0s7ok4uw	5515	18	interactions	interaction	NNS
cord-001835-0s7ok4uw	5515	19	.	.	.
cord-001835-0s7ok4uw	5516	1	Theoretical	theoretical	JJ
cord-001835-0s7ok4uw	5516	2	studies	study	NNS
cord-001835-0s7ok4uw	5516	3	suggest	suggest	VBP
cord-001835-0s7ok4uw	5516	4	that	that	IN
cord-001835-0s7ok4uw	5516	5	the	the	DT
cord-001835-0s7ok4uw	5516	6	three	three	CD
cord-001835-0s7ok4uw	5516	7	-	-	HYPH
cord-001835-0s7ok4uw	5516	8	dimensional	dimensional	JJ
cord-001835-0s7ok4uw	5516	9	structures	structure	NNS
cord-001835-0s7ok4uw	5516	10	of	of	IN
cord-001835-0s7ok4uw	5516	11	present	present	JJ
cord-001835-0s7ok4uw	5516	12	proteins	protein	NNS
cord-001835-0s7ok4uw	5516	13	have	have	VBP
cord-001835-0s7ok4uw	5516	14	evolved	evolve	VBN
cord-001835-0s7ok4uw	5516	15	under	under	IN
cord-001835-0s7ok4uw	5516	16	selective	selective	JJ
cord-001835-0s7ok4uw	5516	17	pressure	pressure	NN
cord-001835-0s7ok4uw	5516	18	to	to	TO
cord-001835-0s7ok4uw	5516	19	avoid	avoid	VB
cord-001835-0s7ok4uw	5516	20	the	the	DT
cord-001835-0s7ok4uw	5516	21	presence	presence	NN
cord-001835-0s7ok4uw	5516	22	of	of	IN
cord-001835-0s7ok4uw	5516	23	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5516	24	-	-	HYPH
cord-001835-0s7ok4uw	5516	25	prone	prone	JJ
cord-001835-0s7ok4uw	5516	26	patches	patch	NNS
cord-001835-0s7ok4uw	5516	27	at	at	IN
cord-001835-0s7ok4uw	5516	28	the	the	DT
cord-001835-0s7ok4uw	5516	29	surface	surface	NN
cord-001835-0s7ok4uw	5516	30	that	that	WDT
cord-001835-0s7ok4uw	5516	31	may	may	MD
cord-001835-0s7ok4uw	5516	32	drive	drive	VB
cord-001835-0s7ok4uw	5516	33	the	the	DT
cord-001835-0s7ok4uw	5516	34	establishment	establishment	NN
cord-001835-0s7ok4uw	5516	35	of	of	IN
cord-001835-0s7ok4uw	5516	36	anomalous	anomalous	JJ
cord-001835-0s7ok4uw	5516	37	protein	protein	NN
cord-001835-0s7ok4uw	5516	38	contacts	contact	NNS
cord-001835-0s7ok4uw	5516	39	.	.	.
cord-001835-0s7ok4uw	5517	1	However	however	RB
cord-001835-0s7ok4uw	5517	2	,	,	,
cord-001835-0s7ok4uw	5517	3	no	no	DT
cord-001835-0s7ok4uw	5517	4	experimental	experimental	JJ
cord-001835-0s7ok4uw	5517	5	evidence	evidence	NN
cord-001835-0s7ok4uw	5517	6	for	for	IN
cord-001835-0s7ok4uw	5517	7	this	this	DT
cord-001835-0s7ok4uw	5517	8	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	5517	9	exists	exist	VBZ
cord-001835-0s7ok4uw	5517	10	so	so	RB
cord-001835-0s7ok4uw	5517	11	far	far	RB
cord-001835-0s7ok4uw	5517	12	.	.	.
cord-001835-0s7ok4uw	5518	1	The	the	DT
cord-001835-0s7ok4uw	5518	2	a	a	DT
cord-001835-0s7ok4uw	5518	3	-	-	HYPH
cord-001835-0s7ok4uw	5518	4	spectrin	spectrin	NN
cord-001835-0s7ok4uw	5518	5	SH3	SH3	NNP
cord-001835-0s7ok4uw	5518	6	domain	domain	NN
cord-001835-0s7ok4uw	5518	7	(	(	-LRB-
cord-001835-0s7ok4uw	5518	8	SPC	SPC	NNP
cord-001835-0s7ok4uw	5518	9	-	-	HYPH
cord-001835-0s7ok4uw	5518	10	SH3	SH3	NNP
cord-001835-0s7ok4uw	5518	11	)	)	-RRB-
cord-001835-0s7ok4uw	5518	12	has	have	VBZ
cord-001835-0s7ok4uw	5518	13	been	be	VBN
cord-001835-0s7ok4uw	5518	14	used	use	VBN
cord-001835-0s7ok4uw	5518	15	as	as	IN
cord-001835-0s7ok4uw	5518	16	a	a	DT
cord-001835-0s7ok4uw	5518	17	protein	protein	NN
cord-001835-0s7ok4uw	5518	18	model	model	NN
cord-001835-0s7ok4uw	5518	19	to	to	TO
cord-001835-0s7ok4uw	5518	20	decipher	decipher	VB
cord-001835-0s7ok4uw	5518	21	the	the	DT
cord-001835-0s7ok4uw	5518	22	sequential	sequential	JJ
cord-001835-0s7ok4uw	5518	23	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5518	24	determinants	determinant	NNS
cord-001835-0s7ok4uw	5518	25	of	of	IN
cord-001835-0s7ok4uw	5518	26	proteins	protein	NNS
cord-001835-0s7ok4uw	5518	27	.	.	.
cord-001835-0s7ok4uw	5519	1	Here	here	RB
cord-001835-0s7ok4uw	5519	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	5519	3	use	use	VBP
cord-001835-0s7ok4uw	5519	4	it	-PRON-	PRP
cord-001835-0s7ok4uw	5519	5	to	to	TO
cord-001835-0s7ok4uw	5519	6	address	address	VB
cord-001835-0s7ok4uw	5519	7	the	the	DT
cord-001835-0s7ok4uw	5519	8	structural	structural	JJ
cord-001835-0s7ok4uw	5519	9	determinants	determinant	NNS
cord-001835-0s7ok4uw	5519	10	of	of	IN
cord-001835-0s7ok4uw	5519	11	protein	protein	NN
cord-001835-0s7ok4uw	5519	12	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5519	13	and	and	CC
cord-001835-0s7ok4uw	5519	14	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5519	15	link	link	NN
cord-001835-0s7ok4uw	5519	16	to	to	IN
cord-001835-0s7ok4uw	5519	17	protein	protein	NN
cord-001835-0s7ok4uw	5519	18	evolution	evolution	NN
cord-001835-0s7ok4uw	5519	19	.	.	.
cord-001835-0s7ok4uw	5520	1	To	to	IN
cord-001835-0s7ok4uw	5520	2	this	this	DT
cord-001835-0s7ok4uw	5520	3	aim	aim	NN
cord-001835-0s7ok4uw	5520	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	5520	5	exploit	exploit	VBP
cord-001835-0s7ok4uw	5520	6	Aggrescan3D	Aggrescan3D	NNP
cord-001835-0s7ok4uw	5520	7	(	(	-LRB-
cord-001835-0s7ok4uw	5520	8	A3D	A3D	NNP
cord-001835-0s7ok4uw	5520	9	)	)	-RRB-
cord-001835-0s7ok4uw	5520	10	,	,	,
cord-001835-0s7ok4uw	5520	11	a	a	DT
cord-001835-0s7ok4uw	5520	12	novel	novel	NN
cord-001835-0s7ok4uw	5520	13	algorithm	algorithm	NN
cord-001835-0s7ok4uw	5520	14	developed	develop	VBN
cord-001835-0s7ok4uw	5520	15	by	by	IN
cord-001835-0s7ok4uw	5520	16	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5520	17	group	group	NN
cord-001835-0s7ok4uw	5520	18	,	,	,
cord-001835-0s7ok4uw	5520	19	which	which	WDT
cord-001835-0s7ok4uw	5520	20	takes	take	VBZ
cord-001835-0s7ok4uw	5520	21	into	into	IN
cord-001835-0s7ok4uw	5520	22	account	account	NN
cord-001835-0s7ok4uw	5520	23	both	both	CC
cord-001835-0s7ok4uw	5520	24	protein	protein	NN
cord-001835-0s7ok4uw	5520	25	structure	structure	NN
cord-001835-0s7ok4uw	5520	26	and	and	CC
cord-001835-0s7ok4uw	5520	27	experimental	experimental	JJ
cord-001835-0s7ok4uw	5520	28	data	datum	NNS
cord-001835-0s7ok4uw	5520	29	to	to	TO
cord-001835-0s7ok4uw	5520	30	project	project	VB
cord-001835-0s7ok4uw	5520	31	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5520	32	propensities	propensity	NNS
cord-001835-0s7ok4uw	5520	33	on	on	IN
cord-001835-0s7ok4uw	5520	34	protein	protein	NN
cord-001835-0s7ok4uw	5520	35	surfaces	surface	NNS
cord-001835-0s7ok4uw	5520	36	.	.	.
cord-001835-0s7ok4uw	5521	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5521	2	used	use	VBD
cord-001835-0s7ok4uw	5521	3	A3D	A3D	NNP
cord-001835-0s7ok4uw	5521	4	to	to	TO
cord-001835-0s7ok4uw	5521	5	design	design	VB
cord-001835-0s7ok4uw	5521	6	a	a	DT
cord-001835-0s7ok4uw	5521	7	series	series	NN
cord-001835-0s7ok4uw	5521	8	of	of	IN
cord-001835-0s7ok4uw	5521	9	SPC	SPC	NNP
cord-001835-0s7ok4uw	5521	10	-	-	HYPH
cord-001835-0s7ok4uw	5521	11	SH3	SH3	NNP
cord-001835-0s7ok4uw	5521	12	variants	variant	NNS
cord-001835-0s7ok4uw	5521	13	with	with	IN
cord-001835-0s7ok4uw	5521	14	progressively	progressively	RB
cord-001835-0s7ok4uw	5521	15	stronger	strong	JJR
cord-001835-0s7ok4uw	5521	16	aggregationprone	aggregationprone	NN
cord-001835-0s7ok4uw	5521	17	surfaces	surface	NNS
cord-001835-0s7ok4uw	5521	18	and	and	CC
cord-001835-0s7ok4uw	5521	19	characterized	characterize	VBD
cord-001835-0s7ok4uw	5521	20	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5521	21	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	5521	22	,	,	,
cord-001835-0s7ok4uw	5521	23	structural	structural	JJ
cord-001835-0s7ok4uw	5521	24	and	and	CC
cord-001835-0s7ok4uw	5521	25	functional	functional	JJ
cord-001835-0s7ok4uw	5521	26	properties	property	NNS
cord-001835-0s7ok4uw	5521	27	.	.	.
cord-001835-0s7ok4uw	5522	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	5522	2	data	data	NN
cord-001835-0s7ok4uw	5522	3	support	support	NN
cord-001835-0s7ok4uw	5522	4	evolution	evolution	NN
cord-001835-0s7ok4uw	5522	5	acting	act	VBG
cord-001835-0s7ok4uw	5522	6	to	to	TO
cord-001835-0s7ok4uw	5522	7	constraint	constraint	VB
cord-001835-0s7ok4uw	5522	8	the	the	DT
cord-001835-0s7ok4uw	5522	9	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5522	10	propensities	propensity	NNS
cord-001835-0s7ok4uw	5522	11	of	of	IN
cord-001835-0s7ok4uw	5522	12	globular	globular	JJ
cord-001835-0s7ok4uw	5522	13	protein	protein	NN
cord-001835-0s7ok4uw	5522	14	surfaces	surface	NNS
cord-001835-0s7ok4uw	5522	15	in	in	IN
cord-001835-0s7ok4uw	5522	16	order	order	NN
cord-001835-0s7ok4uw	5522	17	to	to	TO
cord-001835-0s7ok4uw	5522	18	decrease	decrease	VB
cord-001835-0s7ok4uw	5522	19	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5522	20	potential	potential	JJ
cord-001835-0s7ok4uw	5522	21	cytotoxicity	cytotoxicity	NN
cord-001835-0s7ok4uw	5522	22	and	and	CC
cord-001835-0s7ok4uw	5522	23	the	the	DT
cord-001835-0s7ok4uw	5522	24	protein	protein	NN
cord-001835-0s7ok4uw	5522	25	quality	quality	NN
cord-001835-0s7ok4uw	5522	26	control	control	NN
cord-001835-0s7ok4uw	5522	27	machinery	machinery	NN
cord-001835-0s7ok4uw	5522	28	acting	act	VBG
cord-001835-0s7ok4uw	5522	29	to	to	TO
cord-001835-0s7ok4uw	5522	30	buffer	buffer	VB
cord-001835-0s7ok4uw	5522	31	this	this	DT
cord-001835-0s7ok4uw	5522	32	negative	negative	JJ
cord-001835-0s7ok4uw	5522	33	selective	selective	JJ
cord-001835-0s7ok4uw	5522	34	pressure	pressure	NN
cord-001835-0s7ok4uw	5522	35	.	.	.
cord-001835-0s7ok4uw	5523	1	Utilizing	utilize	VBG
cord-001835-0s7ok4uw	5523	2	3D	3d	JJ
cord-001835-0s7ok4uw	5523	3	structure	structure	NN
cord-001835-0s7ok4uw	5523	4	for	for	IN
cord-001835-0s7ok4uw	5523	5	the	the	DT
cord-001835-0s7ok4uw	5523	6	annotation	annotation	NN
cord-001835-0s7ok4uw	5523	7	of	of	IN
cord-001835-0s7ok4uw	5523	8	structural	structural	JJ
cord-001835-0s7ok4uw	5523	9	motifs	motif	NNS
cord-001835-0s7ok4uw	5523	10	in	in	IN
cord-001835-0s7ok4uw	5523	11	the	the	DT
cord-001835-0s7ok4uw	5523	12	Conserved	Conserved	NNP
cord-001835-0s7ok4uw	5523	13	Domain	Domain	NNP
cord-001835-0s7ok4uw	5523	14	Database	Database	NNP
cord-001835-0s7ok4uw	5523	15	Narmada	Narmada	NNP
cord-001835-0s7ok4uw	5523	16	Thanki	Thanki	NNP
cord-001835-0s7ok4uw	5523	17	-	-	HYPH
cord-001835-0s7ok4uw	5523	18	Cunningham	Cunningham	NNP
cord-001835-0s7ok4uw	5523	19	1	1	CD
cord-001835-0s7ok4uw	5523	20	,	,	,
cord-001835-0s7ok4uw	5523	21	Noreen	Noreen	NNP
cord-001835-0s7ok4uw	5523	22	Gonzales	Gonzales	NNP
cord-001835-0s7ok4uw	5523	23	1	1	CD
cord-001835-0s7ok4uw	5523	24	,	,	,
cord-001835-0s7ok4uw	5523	25	Gabriele	Gabriele	NNP
cord-001835-0s7ok4uw	5523	26	Marchler	Marchler	NNP
cord-001835-0s7ok4uw	5523	27	1	1	CD
cord-001835-0s7ok4uw	5523	28	,	,	,
cord-001835-0s7ok4uw	5523	29	Myra	Myra	NNP
cord-001835-0s7ok4uw	5523	30	Derbyshire	Derbyshire	NNP
cord-001835-0s7ok4uw	5523	31	1	1	CD
cord-001835-0s7ok4uw	5523	32	,	,	,
cord-001835-0s7ok4uw	5523	33	James	James	NNP
cord-001835-0s7ok4uw	5523	34	Song	Song	NNP
cord-001835-0s7ok4uw	5523	35	1	1	CD
cord-001835-0s7ok4uw	5523	36	,	,	,
cord-001835-0s7ok4uw	5523	37	Roxanne	Roxanne	NNP
cord-001835-0s7ok4uw	5523	38	Yamashita	Yamashita	NNP
cord-001835-0s7ok4uw	5523	39	1	1	CD
cord-001835-0s7ok4uw	5523	40	,	,	,
cord-001835-0s7ok4uw	5523	41	Christina	Christina	NNP
cord-001835-0s7ok4uw	5523	42	Zheng	Zheng	NNP
cord-001835-0s7ok4uw	5523	43	1	1	CD
cord-001835-0s7ok4uw	5523	44	,	,	,
cord-001835-0s7ok4uw	5523	45	Stephen	Stephen	NNP
cord-001835-0s7ok4uw	5523	46	Bryant	Bryant	NNP
cord-001835-0s7ok4uw	5523	47	1	1	CD
cord-001835-0s7ok4uw	5523	48	,	,	,
cord-001835-0s7ok4uw	5523	49	Aron	Aron	NNP
cord-001835-0s7ok4uw	5523	50	Marchler	Marchler	NNP
cord-001835-0s7ok4uw	5523	51	-	-	HYPH
cord-001835-0s7ok4uw	5523	52	Bauer	Bauer	NNP
cord-001835-0s7ok4uw	5523	53	1	1	CD
cord-001835-0s7ok4uw	5523	54	,	,	,
cord-001835-0s7ok4uw	5523	55	Farideh	Farideh	NNP
cord-001835-0s7ok4uw	5523	56	Chitsaz1	Chitsaz1	NNP
cord-001835-0s7ok4uw	5524	1	1	1	CD
cord-001835-0s7ok4uw	5524	2	1	1	CD
cord-001835-0s7ok4uw	5524	3	Conserved	Conserved	NNP
cord-001835-0s7ok4uw	5524	4	Domain	Domain	NNP
cord-001835-0s7ok4uw	5524	5	Database	database	NN
cord-001835-0s7ok4uw	5525	1	,	,	,
cord-001835-0s7ok4uw	5525	2	Structure	Structure	NNP
cord-001835-0s7ok4uw	5525	3	Group	Group	NNP
cord-001835-0s7ok4uw	5525	4	CBB	CBB	NNP
cord-001835-0s7ok4uw	5525	5	/	/	SYM
cord-001835-0s7ok4uw	5525	6	NCBI	NCBI	NNP
cord-001835-0s7ok4uw	5525	7	/	/	SYM
cord-001835-0s7ok4uw	5525	8	NLM	NLM	NNP
cord-001835-0s7ok4uw	5525	9	/	/	SYM
cord-001835-0s7ok4uw	5525	10	NIH	NIH	NNP
cord-001835-0s7ok4uw	5526	1	The	the	DT
cord-001835-0s7ok4uw	5526	2	Conserved	Conserved	NNP
cord-001835-0s7ok4uw	5526	3	Domain	Domain	NNP
cord-001835-0s7ok4uw	5526	4	Database	database	NN
cord-001835-0s7ok4uw	5526	5	(	(	-LRB-
cord-001835-0s7ok4uw	5526	6	CDD	CDD	NNP
cord-001835-0s7ok4uw	5526	7	)	)	-RRB-
cord-001835-0s7ok4uw	5526	8	is	be	VBZ
cord-001835-0s7ok4uw	5526	9	a	a	DT
cord-001835-0s7ok4uw	5526	10	protein	protein	NN
cord-001835-0s7ok4uw	5526	11	classification	classification	NN
cord-001835-0s7ok4uw	5526	12	and	and	CC
cord-001835-0s7ok4uw	5526	13	annotation	annotation	NN
cord-001835-0s7ok4uw	5526	14	resource	resource	NN
cord-001835-0s7ok4uw	5526	15	comprised	comprise	VBN
cord-001835-0s7ok4uw	5526	16	of	of	IN
cord-001835-0s7ok4uw	5526	17	multiple	multiple	JJ
cord-001835-0s7ok4uw	5526	18	sequence	sequence	NN
cord-001835-0s7ok4uw	5526	19	alignments	alignment	NNS
cord-001835-0s7ok4uw	5526	20	representing	represent	VBG
cord-001835-0s7ok4uw	5526	21	ancient	ancient	JJ
cord-001835-0s7ok4uw	5526	22	conserved	conserve	VBN
cord-001835-0s7ok4uw	5526	23	domains	domain	NNS
cord-001835-0s7ok4uw	5526	24	.	.	.
cord-001835-0s7ok4uw	5527	1	CDD	CDD	NNP
cord-001835-0s7ok4uw	5527	2	protein	protein	NN
cord-001835-0s7ok4uw	5527	3	domain	domain	NN
cord-001835-0s7ok4uw	5527	4	models	model	NNS
cord-001835-0s7ok4uw	5527	5	are	be	VBP
cord-001835-0s7ok4uw	5527	6	curated	curate	VBN
cord-001835-0s7ok4uw	5527	7	by	by	IN
cord-001835-0s7ok4uw	5527	8	NCBI	NCBI	NNP
cord-001835-0s7ok4uw	5527	9	and	and	CC
cord-001835-0s7ok4uw	5527	10	use	use	VB
cord-001835-0s7ok4uw	5527	11	3D	3D	NNP
cord-001835-0s7ok4uw	5527	12	protein	protein	NN
cord-001835-0s7ok4uw	5527	13	structure	structure	NN
cord-001835-0s7ok4uw	5527	14	explicitly	explicitly	RB
cord-001835-0s7ok4uw	5527	15	to	to	TO
cord-001835-0s7ok4uw	5527	16	define	define	VB
cord-001835-0s7ok4uw	5527	17	domain	domain	NN
cord-001835-0s7ok4uw	5527	18	extent	extent	NN
cord-001835-0s7ok4uw	5527	19	and	and	CC
cord-001835-0s7ok4uw	5527	20	the	the	DT
cord-001835-0s7ok4uw	5527	21	location	location	NN
cord-001835-0s7ok4uw	5527	22	of	of	IN
cord-001835-0s7ok4uw	5527	23	conserved	conserve	VBN
cord-001835-0s7ok4uw	5527	24	core	core	NN
cord-001835-0s7ok4uw	5527	25	structures	structure	NNS
cord-001835-0s7ok4uw	5527	26	,	,	,
cord-001835-0s7ok4uw	5527	27	and	and	CC
cord-001835-0s7ok4uw	5527	28	to	to	TO
cord-001835-0s7ok4uw	5527	29	provide	provide	VB
cord-001835-0s7ok4uw	5527	30	accurate	accurate	JJ
cord-001835-0s7ok4uw	5527	31	alignments	alignment	NNS
cord-001835-0s7ok4uw	5527	32	between	between	IN
cord-001835-0s7ok4uw	5527	33	diverse	diverse	JJ
cord-001835-0s7ok4uw	5527	34	family	family	NN
cord-001835-0s7ok4uw	5527	35	members	member	NNS
cord-001835-0s7ok4uw	5527	36	via	via	IN
cord-001835-0s7ok4uw	5527	37	structure	structure	NN
cord-001835-0s7ok4uw	5527	38	superposition	superposition	NN
cord-001835-0s7ok4uw	5527	39	.	.	.
cord-001835-0s7ok4uw	5528	1	CDD	CDD	NNP
cord-001835-0s7ok4uw	5528	2	also	also	RB
cord-001835-0s7ok4uw	5528	3	imports	import	VBZ
cord-001835-0s7ok4uw	5528	4	external	external	JJ
cord-001835-0s7ok4uw	5528	5	collections	collection	NNS
cord-001835-0s7ok4uw	5528	6	such	such	JJ
cord-001835-0s7ok4uw	5528	7	as	as	IN
cord-001835-0s7ok4uw	5528	8	Pfam	Pfam	NNP
cord-001835-0s7ok4uw	5528	9	and	and	CC
cord-001835-0s7ok4uw	5528	10	TIGRFAM	TIGRFAM	NNP
cord-001835-0s7ok4uw	5528	11	.	.	.
cord-001835-0s7ok4uw	5529	1	Recently	recently	RB
cord-001835-0s7ok4uw	5529	2	,	,	,
cord-001835-0s7ok4uw	5529	3	a	a	DT
cord-001835-0s7ok4uw	5529	4	novel	novel	JJ
cord-001835-0s7ok4uw	5529	5	class	class	NN
cord-001835-0s7ok4uw	5529	6	of	of	IN
cord-001835-0s7ok4uw	5529	7	annotation	annotation	NN
cord-001835-0s7ok4uw	5529	8	labeled	label	VBN
cord-001835-0s7ok4uw	5529	9	as	as	IN
cord-001835-0s7ok4uw	5529	10	"	"	``
cord-001835-0s7ok4uw	5529	11	structural	structural	JJ
cord-001835-0s7ok4uw	5529	12	motifs	motif	NNS
cord-001835-0s7ok4uw	5529	13	"	"	''
cord-001835-0s7ok4uw	5529	14	has	have	VBZ
cord-001835-0s7ok4uw	5529	15	been	be	VBN
cord-001835-0s7ok4uw	5529	16	introduced	introduce	VBN
cord-001835-0s7ok4uw	5529	17	to	to	TO
cord-001835-0s7ok4uw	5529	18	supplement	supplement	VB
cord-001835-0s7ok4uw	5529	19	current	current	JJ
cord-001835-0s7ok4uw	5529	20	capabilities	capability	NNS
cord-001835-0s7ok4uw	5529	21	.	.	.
cord-001835-0s7ok4uw	5530	1	These	these	DT
cord-001835-0s7ok4uw	5530	2	annotations	annotation	NNS
cord-001835-0s7ok4uw	5530	3	define	define	VBP
cord-001835-0s7ok4uw	5530	4	compositionally	compositionally	RB
cord-001835-0s7ok4uw	5530	5	-	-	HYPH
cord-001835-0s7ok4uw	5530	6	biased	bias	VBN
cord-001835-0s7ok4uw	5530	7	and/or	and/or	CC
cord-001835-0s7ok4uw	5530	8	short	short	JJ
cord-001835-0s7ok4uw	5530	9	repetitive	repetitive	JJ
cord-001835-0s7ok4uw	5530	10	regions	region	NNS
cord-001835-0s7ok4uw	5530	11	in	in	IN
cord-001835-0s7ok4uw	5530	12	proteins	protein	NNS
cord-001835-0s7ok4uw	5530	13	,	,	,
cord-001835-0s7ok4uw	5530	14	which	which	WDT
cord-001835-0s7ok4uw	5530	15	are	be	VBP
cord-001835-0s7ok4uw	5530	16	difficult	difficult	JJ
cord-001835-0s7ok4uw	5530	17	to	to	TO
cord-001835-0s7ok4uw	5530	18	model	model	VB
cord-001835-0s7ok4uw	5530	19	as	as	IN
cord-001835-0s7ok4uw	5530	20	functional	functional	JJ
cord-001835-0s7ok4uw	5530	21	domains	domain	NNS
cord-001835-0s7ok4uw	5530	22	conserved	conserve	VBN
cord-001835-0s7ok4uw	5530	23	in	in	IN
cord-001835-0s7ok4uw	5530	24	molecular	molecular	JJ
cord-001835-0s7ok4uw	5530	25	evolution	evolution	NN
cord-001835-0s7ok4uw	5530	26	.	.	.
cord-001835-0s7ok4uw	5531	1	Structural	structural	JJ
cord-001835-0s7ok4uw	5531	2	motifs	motif	NNS
cord-001835-0s7ok4uw	5531	3	include	include	VBP
cord-001835-0s7ok4uw	5531	4	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	5531	5	regions	region	NNS
cord-001835-0s7ok4uw	5531	6	,	,	,
cord-001835-0s7ok4uw	5531	7	coiled	coiled	JJ
cord-001835-0s7ok4uw	5531	8	coils	coil	NNS
cord-001835-0s7ok4uw	5531	9	,	,	,
cord-001835-0s7ok4uw	5531	10	and	and	CC
cord-001835-0s7ok4uw	5531	11	short	short	JJ
cord-001835-0s7ok4uw	5531	12	repeats	repeat	NNS
cord-001835-0s7ok4uw	5531	13	with	with	IN
cord-001835-0s7ok4uw	5531	14	variable	variable	JJ
cord-001835-0s7ok4uw	5531	15	copy	copy	NN
cord-001835-0s7ok4uw	5531	16	numbers	number	NNS
cord-001835-0s7ok4uw	5531	17	.	.	.
cord-001835-0s7ok4uw	5532	1	For	for	IN
cord-001835-0s7ok4uw	5532	2	many	many	JJ
cord-001835-0s7ok4uw	5532	3	types	type	NNS
cord-001835-0s7ok4uw	5532	4	of	of	IN
cord-001835-0s7ok4uw	5532	5	short	short	JJ
cord-001835-0s7ok4uw	5532	6	tandem	tandem	NN
cord-001835-0s7ok4uw	5532	7	repeats	repeat	NNS
cord-001835-0s7ok4uw	5532	8	,	,	,
cord-001835-0s7ok4uw	5532	9	a	a	DT
cord-001835-0s7ok4uw	5532	10	few	few	JJ
cord-001835-0s7ok4uw	5532	11	position	position	NN
cord-001835-0s7ok4uw	5532	12	-	-	HYPH
cord-001835-0s7ok4uw	5532	13	specific	specific	JJ
cord-001835-0s7ok4uw	5532	14	score	score	NN
cord-001835-0s7ok4uw	5532	15	matrices	matrix	NNS
cord-001835-0s7ok4uw	5532	16	(	(	-LRB-
cord-001835-0s7ok4uw	5532	17	PSSMs	pssm	NNS
cord-001835-0s7ok4uw	5532	18	)	)	-RRB-
cord-001835-0s7ok4uw	5532	19	suffice	suffice	VBP
cord-001835-0s7ok4uw	5532	20	to	to	TO
cord-001835-0s7ok4uw	5532	21	annotate	annotate	VB
cord-001835-0s7ok4uw	5532	22	more	more	JJR
cord-001835-0s7ok4uw	5532	23	than	than	IN
cord-001835-0s7ok4uw	5532	24	90	90	CD
cord-001835-0s7ok4uw	5532	25	%	%	NN
cord-001835-0s7ok4uw	5532	26	of	of	IN
cord-001835-0s7ok4uw	5532	27	the	the	DT
cord-001835-0s7ok4uw	5532	28	known	know	VBN
cord-001835-0s7ok4uw	5532	29	instances	instance	NNS
cord-001835-0s7ok4uw	5532	30	of	of	IN
cord-001835-0s7ok4uw	5532	31	that	that	DT
cord-001835-0s7ok4uw	5532	32	structural	structural	JJ
cord-001835-0s7ok4uw	5532	33	motif	motif	NN
cord-001835-0s7ok4uw	5532	34	.	.	.
cord-001835-0s7ok4uw	5533	1	Unfortunately	unfortunately	RB
cord-001835-0s7ok4uw	5533	2	,	,	,
cord-001835-0s7ok4uw	5533	3	a	a	DT
cord-001835-0s7ok4uw	5533	4	lack	lack	NN
cord-001835-0s7ok4uw	5533	5	of	of	IN
cord-001835-0s7ok4uw	5533	6	sequence	sequence	NN
cord-001835-0s7ok4uw	5533	7	similarity	similarity	NN
cord-001835-0s7ok4uw	5533	8	within	within	IN
cord-001835-0s7ok4uw	5533	9	coiled	coil	VBN
cord-001835-0s7ok4uw	5533	10	-	-	HYPH
cord-001835-0s7ok4uw	5533	11	coil	coil	NN
cord-001835-0s7ok4uw	5533	12	regions	region	NNS
cord-001835-0s7ok4uw	5533	13	prohibits	prohibit	VBZ
cord-001835-0s7ok4uw	5533	14	the	the	DT
cord-001835-0s7ok4uw	5533	15	development	development	NN
cord-001835-0s7ok4uw	5533	16	of	of	IN
cord-001835-0s7ok4uw	5533	17	only	only	RB
cord-001835-0s7ok4uw	5533	18	a	a	DT
cord-001835-0s7ok4uw	5533	19	few	few	JJ
cord-001835-0s7ok4uw	5533	20	generic	generic	JJ
cord-001835-0s7ok4uw	5533	21	models	model	NNS
cord-001835-0s7ok4uw	5533	22	;	;	:
cord-001835-0s7ok4uw	5533	23	therefore	therefore	RB
cord-001835-0s7ok4uw	5533	24	,	,	,
cord-001835-0s7ok4uw	5533	25	models	model	NNS
cord-001835-0s7ok4uw	5533	26	for	for	IN
cord-001835-0s7ok4uw	5533	27	coiled	coil	VBN
cord-001835-0s7ok4uw	5533	28	-	-	HYPH
cord-001835-0s7ok4uw	5533	29	coil	coil	NN
cord-001835-0s7ok4uw	5533	30	regions	region	NNS
cord-001835-0s7ok4uw	5533	31	in	in	IN
cord-001835-0s7ok4uw	5533	32	the	the	DT
cord-001835-0s7ok4uw	5533	33	context	context	NN
cord-001835-0s7ok4uw	5533	34	of	of	IN
cord-001835-0s7ok4uw	5533	35	specific	specific	JJ
cord-001835-0s7ok4uw	5533	36	families	family	NNS
cord-001835-0s7ok4uw	5533	37	have	have	VBP
cord-001835-0s7ok4uw	5533	38	been	be	VBN
cord-001835-0s7ok4uw	5533	39	developed	develop	VBN
cord-001835-0s7ok4uw	5533	40	using	use	VBG
cord-001835-0s7ok4uw	5533	41	the	the	DT
cord-001835-0s7ok4uw	5533	42	Spiricoil	Spiricoil	NNP
cord-001835-0s7ok4uw	5533	43	Database	Database	NNP
cord-001835-0s7ok4uw	5533	44	as	as	IN
cord-001835-0s7ok4uw	5533	45	a	a	DT
cord-001835-0s7ok4uw	5533	46	reference	reference	NN
cord-001835-0s7ok4uw	5533	47	.	.	.
cord-001835-0s7ok4uw	5534	1	Increased	increase	VBN
cord-001835-0s7ok4uw	5534	2	coverage	coverage	NN
cord-001835-0s7ok4uw	5534	3	of	of	IN
cord-001835-0s7ok4uw	5534	4	coiled	coil	VBN
cord-001835-0s7ok4uw	5534	5	-	-	HYPH
cord-001835-0s7ok4uw	5534	6	coil	coil	NN
cord-001835-0s7ok4uw	5534	7	regions	region	NNS
cord-001835-0s7ok4uw	5534	8	in	in	IN
cord-001835-0s7ok4uw	5534	9	CDD	CDD	NNP
cord-001835-0s7ok4uw	5534	10	,	,	,
cord-001835-0s7ok4uw	5534	11	specific	specific	JJ
cord-001835-0s7ok4uw	5534	12	site	site	NN
cord-001835-0s7ok4uw	5534	13	annotations	annotation	NNS
cord-001835-0s7ok4uw	5534	14	of	of	IN
cord-001835-0s7ok4uw	5534	15	these	these	DT
cord-001835-0s7ok4uw	5534	16	structural	structural	JJ
cord-001835-0s7ok4uw	5534	17	motifs	motif	NNS
cord-001835-0s7ok4uw	5534	18	as	as	RB
cord-001835-0s7ok4uw	5534	19	well	well	RB
cord-001835-0s7ok4uw	5534	20	as	as	IN
cord-001835-0s7ok4uw	5534	21	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5534	22	representation	representation	NN
cord-001835-0s7ok4uw	5534	23	on	on	IN
cord-001835-0s7ok4uw	5534	24	the	the	DT
cord-001835-0s7ok4uw	5534	25	webpages	webpage	NNS
cord-001835-0s7ok4uw	5534	26	will	will	MD
cord-001835-0s7ok4uw	5534	27	be	be	VB
cord-001835-0s7ok4uw	5534	28	discussed	discuss	VBN
cord-001835-0s7ok4uw	5534	29	.	.	.
cord-001835-0s7ok4uw	5535	1	specific	specific	JJ
cord-001835-0s7ok4uw	5535	2	in	in	IN
cord-001835-0s7ok4uw	5535	3	vivo	vivo	NNP
cord-001835-0s7ok4uw	5535	4	ultrasound	ultrasound	NN
cord-001835-0s7ok4uw	5535	5	imaging	imaging	NN
cord-001835-0s7ok4uw	5535	6	of	of	IN
cord-001835-0s7ok4uw	5535	7	E	e	NN
cord-001835-0s7ok4uw	5535	8	-	-	JJ
cord-001835-0s7ok4uw	5535	9	selectin	selectin	JJ
cord-001835-0s7ok4uw	5535	10	expression	expression	NN
cord-001835-0s7ok4uw	5535	11	in	in	IN
cord-001835-0s7ok4uw	5535	12	tumors	tumor	NNS
cord-001835-0s7ok4uw	5535	13	using	use	VBG
cord-001835-0s7ok4uw	5535	14	a	a	DT
cord-001835-0s7ok4uw	5535	15	microbubble	microbubble	JJ
cord-001835-0s7ok4uw	5535	16	contrast	contrast	NN
cord-001835-0s7ok4uw	5535	17	agent	agent	NN
cord-001835-0s7ok4uw	5535	18	covalently	covalently	RB
cord-001835-0s7ok4uw	5535	19	attached	attach	VBN
cord-001835-0s7ok4uw	5535	20	to	to	IN
cord-001835-0s7ok4uw	5535	21	the	the	DT
cord-001835-0s7ok4uw	5535	22	peptide	peptide	NN
cord-001835-0s7ok4uw	5535	23	ligand	ligand	NN
cord-001835-0s7ok4uw	5535	24	IELLQAR	IELLQAR	NNP
cord-001835-0s7ok4uw	5535	25	,	,	,
cord-001835-0s7ok4uw	5535	26	known	know	VBN
cord-001835-0s7ok4uw	5535	27	to	to	TO
cord-001835-0s7ok4uw	5535	28	bind	bind	VB
cord-001835-0s7ok4uw	5535	29	to	to	IN
cord-001835-0s7ok4uw	5535	30	E	e	NN
cord-001835-0s7ok4uw	5535	31	-	-	NN
cord-001835-0s7ok4uw	5535	32	selectin	selectin	JJ
cord-001835-0s7ok4uw	5535	33	[	[	-LRB-
cord-001835-0s7ok4uw	5535	34	2	2	CD
cord-001835-0s7ok4uw	5535	35	]	]	-RRB-
cord-001835-0s7ok4uw	5535	36	.	.	.
cord-001835-0s7ok4uw	5536	1	However	however	RB
cord-001835-0s7ok4uw	5536	2	,	,	,
cord-001835-0s7ok4uw	5536	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	5536	4	was	be	VBD
cord-001835-0s7ok4uw	5536	5	observed	observe	VBN
cord-001835-0s7ok4uw	5536	6	that	that	IN
cord-001835-0s7ok4uw	5536	7	this	this	DT
cord-001835-0s7ok4uw	5536	8	probe	probe	NN
cord-001835-0s7ok4uw	5536	9	has	have	VBZ
cord-001835-0s7ok4uw	5536	10	a	a	DT
cord-001835-0s7ok4uw	5536	11	limitation	limitation	NN
cord-001835-0s7ok4uw	5536	12	in	in	IN
cord-001835-0s7ok4uw	5536	13	the	the	DT
cord-001835-0s7ok4uw	5536	14	imaging	imaging	NN
cord-001835-0s7ok4uw	5536	15	of	of	IN
cord-001835-0s7ok4uw	5536	16	cardiovascular	cardiovascular	JJ
cord-001835-0s7ok4uw	5536	17	diseases	disease	NNS
cord-001835-0s7ok4uw	5536	18	where	where	WRB
cord-001835-0s7ok4uw	5536	19	higher	high	JJR
cord-001835-0s7ok4uw	5536	20	shear	shear	NN
cord-001835-0s7ok4uw	5536	21	stresses	stress	NNS
cord-001835-0s7ok4uw	5536	22	prevent	prevent	VBP
cord-001835-0s7ok4uw	5536	23	microbubbles	microbubble	NNS
cord-001835-0s7ok4uw	5536	24	from	from	IN
cord-001835-0s7ok4uw	5536	25	remaining	remain	VBG
cord-001835-0s7ok4uw	5536	26	attached	attach	VBN
cord-001835-0s7ok4uw	5536	27	to	to	IN
cord-001835-0s7ok4uw	5536	28	the	the	DT
cord-001835-0s7ok4uw	5536	29	target	target	NN
cord-001835-0s7ok4uw	5536	30	.	.	.
cord-001835-0s7ok4uw	5537	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	5537	2	,	,	,
cord-001835-0s7ok4uw	5537	3	peptides	peptide	NNS
cord-001835-0s7ok4uw	5537	4	with	with	IN
cord-001835-0s7ok4uw	5537	5	higher	high	JJR
cord-001835-0s7ok4uw	5537	6	Eselectin	Eselectin	NNP
cord-001835-0s7ok4uw	5537	7	affinity	affinity	NN
cord-001835-0s7ok4uw	5537	8	are	be	VBP
cord-001835-0s7ok4uw	5537	9	needed	need	VBN
cord-001835-0s7ok4uw	5537	10	to	to	TO
cord-001835-0s7ok4uw	5537	11	design	design	VB
cord-001835-0s7ok4uw	5537	12	probes	probe	NNS
cord-001835-0s7ok4uw	5537	13	capable	capable	JJ
cord-001835-0s7ok4uw	5537	14	of	of	IN
cord-001835-0s7ok4uw	5537	15	imaging	image	VBG
cord-001835-0s7ok4uw	5537	16	these	these	DT
cord-001835-0s7ok4uw	5537	17	diseases	disease	NNS
cord-001835-0s7ok4uw	5537	18	.	.	.
cord-001835-0s7ok4uw	5538	1	In	in	IN
cord-001835-0s7ok4uw	5538	2	this	this	DT
cord-001835-0s7ok4uw	5538	3	context	context	NN
cord-001835-0s7ok4uw	5538	4	,	,	,
cord-001835-0s7ok4uw	5538	5	automated	automate	VBN
cord-001835-0s7ok4uw	5538	6	docking	docking	NN
cord-001835-0s7ok4uw	5538	7	and	and	CC
cord-001835-0s7ok4uw	5538	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	5538	9	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	5538	10	methodologies	methodology	NNS
cord-001835-0s7ok4uw	5538	11	were	be	VBD
cord-001835-0s7ok4uw	5538	12	combined	combine	VBN
cord-001835-0s7ok4uw	5538	13	and	and	CC
cord-001835-0s7ok4uw	5538	14	applied	apply	VBN
cord-001835-0s7ok4uw	5538	15	to	to	IN
cord-001835-0s7ok4uw	5538	16	different	different	JJ
cord-001835-0s7ok4uw	5538	17	E	e	NN
cord-001835-0s7ok4uw	5538	18	-	-	NN
cord-001835-0s7ok4uw	5538	19	selectin	selectin	JJ
cord-001835-0s7ok4uw	5538	20	binding	binding	NN
cord-001835-0s7ok4uw	5538	21	peptides	peptide	NNS
cord-001835-0s7ok4uw	5538	22	.	.	.
cord-001835-0s7ok4uw	5539	1	These	these	DT
cord-001835-0s7ok4uw	5539	2	studies	study	NNS
cord-001835-0s7ok4uw	5539	3	predicted	predict	VBD
cord-001835-0s7ok4uw	5539	4	the	the	DT
cord-001835-0s7ok4uw	5539	5	energetically	energetically	RB
cord-001835-0s7ok4uw	5539	6	more	more	RBR
cord-001835-0s7ok4uw	5539	7	favorable	favorable	JJ
cord-001835-0s7ok4uw	5539	8	binding	binding	NN
cord-001835-0s7ok4uw	5539	9	mode	mode	NN
cord-001835-0s7ok4uw	5539	10	as	as	RB
cord-001835-0s7ok4uw	5539	11	well	well	RB
cord-001835-0s7ok4uw	5539	12	as	as	IN
cord-001835-0s7ok4uw	5539	13	the	the	DT
cord-001835-0s7ok4uw	5539	14	key	key	JJ
cord-001835-0s7ok4uw	5539	15	interactions	interaction	NNS
cord-001835-0s7ok4uw	5539	16	between	between	IN
cord-001835-0s7ok4uw	5539	17	the	the	DT
cord-001835-0s7ok4uw	5539	18	peptide	peptide	NN
cord-001835-0s7ok4uw	5539	19	ligands	ligand	NNS
cord-001835-0s7ok4uw	5539	20	and	and	CC
cord-001835-0s7ok4uw	5539	21	the	the	DT
cord-001835-0s7ok4uw	5539	22	E	e	NN
cord-001835-0s7ok4uw	5539	23	-	-	NN
cord-001835-0s7ok4uw	5539	24	selectin	selectin	JJ
cord-001835-0s7ok4uw	5539	25	receptor	receptor	NN
cord-001835-0s7ok4uw	5539	26	.	.	.
cord-001835-0s7ok4uw	5540	1	Some	some	DT
cord-001835-0s7ok4uw	5540	2	of	of	IN
cord-001835-0s7ok4uw	5540	3	these	these	DT
cord-001835-0s7ok4uw	5540	4	peptides	peptide	NNS
cord-001835-0s7ok4uw	5540	5	were	be	VBD
cord-001835-0s7ok4uw	5540	6	prepared	prepare	VBN
cord-001835-0s7ok4uw	5540	7	by	by	IN
cord-001835-0s7ok4uw	5540	8	solid	solid	JJ
cord-001835-0s7ok4uw	5540	9	-	-	HYPH
cord-001835-0s7ok4uw	5540	10	phase	phase	NN
cord-001835-0s7ok4uw	5540	11	peptide	peptide	NN
cord-001835-0s7ok4uw	5540	12	synthesis	synthesis	NN
cord-001835-0s7ok4uw	5540	13	and	and	CC
cord-001835-0s7ok4uw	5540	14	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5540	15	interactions	interaction	NNS
cord-001835-0s7ok4uw	5540	16	with	with	IN
cord-001835-0s7ok4uw	5540	17	E	e	NN
cord-001835-0s7ok4uw	5540	18	-	-	NN
cord-001835-0s7ok4uw	5540	19	selectin	selectin	NNP
cord-001835-0s7ok4uw	5540	20	analyzed	analyze	VBN
cord-001835-0s7ok4uw	5540	21	by	by	IN
cord-001835-0s7ok4uw	5540	22	surface	surface	NN
cord-001835-0s7ok4uw	5540	23	plasmon	plasmon	JJ
cord-001835-0s7ok4uw	5540	24	resonance	resonance	NN
cord-001835-0s7ok4uw	5540	25	technique	technique	NN
cord-001835-0s7ok4uw	5540	26	.	.	.
cord-001835-0s7ok4uw	5541	1	The	the	DT
cord-001835-0s7ok4uw	5541	2	results	result	NNS
cord-001835-0s7ok4uw	5541	3	showed	show	VBD
cord-001835-0s7ok4uw	5541	4	that	that	IN
cord-001835-0s7ok4uw	5541	5	these	these	DT
cord-001835-0s7ok4uw	5541	6	peptides	peptide	NNS
cord-001835-0s7ok4uw	5541	7	have	have	VBP
cord-001835-0s7ok4uw	5541	8	different	different	JJ
cord-001835-0s7ok4uw	5541	9	affinities	affinity	NNS
cord-001835-0s7ok4uw	5541	10	for	for	IN
cord-001835-0s7ok4uw	5541	11	E	e	NN
cord-001835-0s7ok4uw	5541	12	-	-	NN
cord-001835-0s7ok4uw	5541	13	selectin	selectin	JJ
cord-001835-0s7ok4uw	5541	14	.	.	.
cord-001835-0s7ok4uw	5542	1	These	these	DT
cord-001835-0s7ok4uw	5542	2	data	datum	NNS
cord-001835-0s7ok4uw	5542	3	were	be	VBD
cord-001835-0s7ok4uw	5542	4	correlated	correlate	VBN
cord-001835-0s7ok4uw	5542	5	with	with	IN
cord-001835-0s7ok4uw	5542	6	the	the	DT
cord-001835-0s7ok4uw	5542	7	computational	computational	JJ
cord-001835-0s7ok4uw	5542	8	studies	study	NNS
cord-001835-0s7ok4uw	5542	9	and	and	CC
cord-001835-0s7ok4uw	5542	10	evaluated	evaluate	VBD
cord-001835-0s7ok4uw	5542	11	to	to	TO
cord-001835-0s7ok4uw	5542	12	obtain	obtain	VB
cord-001835-0s7ok4uw	5542	13	crucial	crucial	JJ
cord-001835-0s7ok4uw	5542	14	information	information	NN
cord-001835-0s7ok4uw	5542	15	of	of	IN
cord-001835-0s7ok4uw	5542	16	the	the	DT
cord-001835-0s7ok4uw	5542	17	key	key	JJ
cord-001835-0s7ok4uw	5542	18	recognition	recognition	NN
cord-001835-0s7ok4uw	5542	19	elements	element	NNS
cord-001835-0s7ok4uw	5542	20	needed	need	VBN
cord-001835-0s7ok4uw	5542	21	for	for	IN
cord-001835-0s7ok4uw	5542	22	higher	high	JJR
cord-001835-0s7ok4uw	5542	23	E	e	NN
cord-001835-0s7ok4uw	5542	24	-	-	JJ
cord-001835-0s7ok4uw	5542	25	selectin	selectin	JJ
cord-001835-0s7ok4uw	5542	26	affinity	affinity	NN
cord-001835-0s7ok4uw	5542	27	.	.	.
cord-001835-0s7ok4uw	5543	1	These	these	DT
cord-001835-0s7ok4uw	5543	2	recent	recent	JJ
cord-001835-0s7ok4uw	5543	3	results	result	NNS
cord-001835-0s7ok4uw	5543	4	will	will	MD
cord-001835-0s7ok4uw	5543	5	be	be	VB
cord-001835-0s7ok4uw	5543	6	presented	present	VBN
cord-001835-0s7ok4uw	5543	7	.	.	.
cord-001835-0s7ok4uw	5543	8	 	 	_SP
cord-001835-0s7ok4uw	5544	1	Burkholderia	Burkholderia	NNP
cord-001835-0s7ok4uw	5544	2	pseudomallei	pseudomallei	NN
cord-001835-0s7ok4uw	5544	3	is	be	VBZ
cord-001835-0s7ok4uw	5544	4	the	the	DT
cord-001835-0s7ok4uw	5544	5	causative	causative	JJ
cord-001835-0s7ok4uw	5544	6	agent	agent	NN
cord-001835-0s7ok4uw	5544	7	of	of	IN
cord-001835-0s7ok4uw	5544	8	melioidosis	melioidosis	NNP
cord-001835-0s7ok4uw	5544	9	,	,	,
cord-001835-0s7ok4uw	5544	10	a	a	DT
cord-001835-0s7ok4uw	5544	11	serious	serious	JJ
cord-001835-0s7ok4uw	5544	12	invasive	invasive	JJ
cord-001835-0s7ok4uw	5544	13	disease	disease	NN
cord-001835-0s7ok4uw	5544	14	of	of	IN
cord-001835-0s7ok4uw	5544	15	animals	animal	NNS
cord-001835-0s7ok4uw	5544	16	and	and	CC
cord-001835-0s7ok4uw	5544	17	humans	human	NNS
cord-001835-0s7ok4uw	5544	18	in	in	IN
cord-001835-0s7ok4uw	5544	19	tropical	tropical	JJ
cord-001835-0s7ok4uw	5544	20	and	and	CC
cord-001835-0s7ok4uw	5544	21	subtropical	subtropical	JJ
cord-001835-0s7ok4uw	5544	22	areas	area	NNS
cord-001835-0s7ok4uw	5544	23	.	.	.
cord-001835-0s7ok4uw	5545	1	Sedoheptulose-7-phosphate	Sedoheptulose-7-phosphate	NNP
cord-001835-0s7ok4uw	5545	2	isomerase	isomerase	NN
cord-001835-0s7ok4uw	5545	3	from	from	IN
cord-001835-0s7ok4uw	5545	4	B.	B.	NNP
cord-001835-0s7ok4uw	5545	5	pseudomallei	pseudomallei	NN
cord-001835-0s7ok4uw	5545	6	(	(	-LRB-
cord-001835-0s7ok4uw	5545	7	BpGmhA	BpGmhA	NNP
cord-001835-0s7ok4uw	5545	8	)	)	-RRB-
cord-001835-0s7ok4uw	5545	9	is	be	VBZ
cord-001835-0s7ok4uw	5545	10	the	the	DT
cord-001835-0s7ok4uw	5545	11	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	5545	12	adjuvant	adjuvant	JJ
cord-001835-0s7ok4uw	5545	13	target	target	NN
cord-001835-0s7ok4uw	5545	14	for	for	IN
cord-001835-0s7ok4uw	5545	15	melioidosis	melioidosis	NN
cord-001835-0s7ok4uw	5545	16	.	.	.
cord-001835-0s7ok4uw	5546	1	In	in	IN
cord-001835-0s7ok4uw	5546	2	general	general	JJ
cord-001835-0s7ok4uw	5546	3	,	,	,
cord-001835-0s7ok4uw	5546	4	BpGmhA	BpGmhA	NNP
cord-001835-0s7ok4uw	5546	5	converts	convert	VBZ
cord-001835-0s7ok4uw	5546	6	dsedoheptulose-7-phosphate	dsedoheptulose-7-phosphate	NN
cord-001835-0s7ok4uw	5546	7	to	to	IN
cord-001835-0s7ok4uw	5546	8	d	d	JJ
cord-001835-0s7ok4uw	5546	9	-	-	:
cord-001835-0s7ok4uw	5546	10	glycero	glycero	NNP
cord-001835-0s7ok4uw	5546	11	-	-	HYPH
cord-001835-0s7ok4uw	5546	12	a	a	DT
cord-001835-0s7ok4uw	5546	13	-	-	HYPH
cord-001835-0s7ok4uw	5546	14	d	d	NN
cord-001835-0s7ok4uw	5546	15	-	-	HYPH
cord-001835-0s7ok4uw	5546	16	manno	manno	JJ
cord-001835-0s7ok4uw	5546	17	-	-	HYPH
cord-001835-0s7ok4uw	5546	18	heptopyranose-7-phosphate	heptopyranose-7-phosphate	NNP
cord-001835-0s7ok4uw	5546	19	(	(	-LRB-
cord-001835-0s7ok4uw	5546	20	M7P	m7p	NN
cord-001835-0s7ok4uw	5546	21	)	)	-RRB-
cord-001835-0s7ok4uw	5546	22	.	.	.
cord-001835-0s7ok4uw	5547	1	This	this	DT
cord-001835-0s7ok4uw	5547	2	is	be	VBZ
cord-001835-0s7ok4uw	5547	3	the	the	DT
cord-001835-0s7ok4uw	5547	4	first	first	JJ
cord-001835-0s7ok4uw	5547	5	step	step	NN
cord-001835-0s7ok4uw	5547	6	of	of	IN
cord-001835-0s7ok4uw	5547	7	the	the	DT
cord-001835-0s7ok4uw	5547	8	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	5547	9	pathway	pathway	NN
cord-001835-0s7ok4uw	5547	10	of	of	IN
cord-001835-0s7ok4uw	5547	11	NDP	NDP	NNP
cord-001835-0s7ok4uw	5547	12	-	-	HYPH
cord-001835-0s7ok4uw	5547	13	heptose	heptose	NNP
cord-001835-0s7ok4uw	5547	14	responsible	responsible	JJ
cord-001835-0s7ok4uw	5547	15	for	for	IN
cord-001835-0s7ok4uw	5547	16	a	a	DT
cord-001835-0s7ok4uw	5547	17	pleiotropic	pleiotropic	JJ
cord-001835-0s7ok4uw	5547	18	phenotype	phenotype	NN
cord-001835-0s7ok4uw	5547	19	.	.	.
cord-001835-0s7ok4uw	5548	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	5548	2	,	,	,
cord-001835-0s7ok4uw	5548	3	this	this	DT
cord-001835-0s7ok4uw	5548	4	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	5548	5	pathway	pathway	NN
cord-001835-0s7ok4uw	5548	6	is	be	VBZ
cord-001835-0s7ok4uw	5548	7	the	the	DT
cord-001835-0s7ok4uw	5548	8	target	target	NN
cord-001835-0s7ok4uw	5548	9	for	for	IN
cord-001835-0s7ok4uw	5548	10	searching	search	VBG
cord-001835-0s7ok4uw	5548	11	novel	novel	JJ
cord-001835-0s7ok4uw	5548	12	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	5548	13	increasing	increase	VBG
cord-001835-0s7ok4uw	5548	14	the	the	DT
cord-001835-0s7ok4uw	5548	15	membrane	membrane	NN
cord-001835-0s7ok4uw	5548	16	permeability	permeability	NN
cord-001835-0s7ok4uw	5548	17	of	of	IN
cord-001835-0s7ok4uw	5548	18	Gram	gram	NN
cord-001835-0s7ok4uw	5548	19	-	-	HYPH
cord-001835-0s7ok4uw	5548	20	negative	negative	JJ
cord-001835-0s7ok4uw	5548	21	pathogens	pathogen	NNS
cord-001835-0s7ok4uw	5548	22	or	or	CC
cord-001835-0s7ok4uw	5548	23	adjuvants	adjuvant	NNS
cord-001835-0s7ok4uw	5548	24	synergistically	synergistically	RB
cord-001835-0s7ok4uw	5548	25	working	work	VBG
cord-001835-0s7ok4uw	5548	26	with	with	IN
cord-001835-0s7ok4uw	5548	27	known	know	VBN
cord-001835-0s7ok4uw	5548	28	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	5548	29	.	.	.
cord-001835-0s7ok4uw	5549	1	The	the	DT
cord-001835-0s7ok4uw	5549	2	crystal	crystal	NN
cord-001835-0s7ok4uw	5549	3	of	of	IN
cord-001835-0s7ok4uw	5549	4	this	this	DT
cord-001835-0s7ok4uw	5549	5	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5549	6	has	have	VBZ
cord-001835-0s7ok4uw	5549	7	been	be	VBN
cord-001835-0s7ok4uw	5549	8	solved	solve	VBN
cord-001835-0s7ok4uw	5549	9	at	at	IN
cord-001835-0s7ok4uw	5549	10	1.9	1.9	CD
cord-001835-0s7ok4uw	5549	11	Å	å	NN
cord-001835-0s7ok4uw	5549	12	resolution	resolution	NN
cord-001835-0s7ok4uw	5549	13	.	.	.
cord-001835-0s7ok4uw	5550	1	There	there	EX
cord-001835-0s7ok4uw	5550	2	is	be	VBZ
cord-001835-0s7ok4uw	5550	3	an	an	DT
cord-001835-0s7ok4uw	5550	4	active	active	JJ
cord-001835-0s7ok4uw	5550	5	site	site	NN
cord-001835-0s7ok4uw	5550	6	pocket	pocket	NN
cord-001835-0s7ok4uw	5550	7	where	where	WRB
cord-001835-0s7ok4uw	5550	8	a	a	DT
cord-001835-0s7ok4uw	5550	9	putative	putative	JJ
cord-001835-0s7ok4uw	5550	10	metal	metal	NN
cord-001835-0s7ok4uw	5550	11	binding	binding	NN
cord-001835-0s7ok4uw	5550	12	site	site	NN
cord-001835-0s7ok4uw	5550	13	is	be	VBZ
cord-001835-0s7ok4uw	5550	14	located	locate	VBN
cord-001835-0s7ok4uw	5550	15	.	.	.
cord-001835-0s7ok4uw	5551	1	To	to	TO
cord-001835-0s7ok4uw	5551	2	find	find	VB
cord-001835-0s7ok4uw	5551	3	out	out	RP
cord-001835-0s7ok4uw	5551	4	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	5551	5	of	of	IN
cord-001835-0s7ok4uw	5551	6	BpGmhA	BpGmhA	NNP
cord-001835-0s7ok4uw	5551	7	,	,	,
cord-001835-0s7ok4uw	5551	8	in	in	IN
cord-001835-0s7ok4uw	5551	9	-	-	HYPH
cord-001835-0s7ok4uw	5551	10	silico	silico	NN
cord-001835-0s7ok4uw	5551	11	virtual	virtual	JJ
cord-001835-0s7ok4uw	5551	12	screening	screening	NN
cord-001835-0s7ok4uw	5551	13	with	with	IN
cord-001835-0s7ok4uw	5551	14	ZINC	zinc	NN
cord-001835-0s7ok4uw	5551	15	,	,	,
cord-001835-0s7ok4uw	5551	16	a	a	DT
cord-001835-0s7ok4uw	5551	17	free	free	JJ
cord-001835-0s7ok4uw	5551	18	database	database	NN
cord-001835-0s7ok4uw	5551	19	of	of	IN
cord-001835-0s7ok4uw	5551	20	commercially	commercially	RB
cord-001835-0s7ok4uw	5551	21	-	-	HYPH
cord-001835-0s7ok4uw	5551	22	available	available	JJ
cord-001835-0s7ok4uw	5551	23	compounds	compound	NNS
cord-001835-0s7ok4uw	5551	24	,	,	,
cord-001835-0s7ok4uw	5551	25	has	have	VBZ
cord-001835-0s7ok4uw	5551	26	been	be	VBN
cord-001835-0s7ok4uw	5551	27	performed	perform	VBN
cord-001835-0s7ok4uw	5551	28	.	.	.
cord-001835-0s7ok4uw	5552	1	Tens	ten	NNS
cord-001835-0s7ok4uw	5552	2	of	of	IN
cord-001835-0s7ok4uw	5552	3	thousands	thousand	NNS
cord-001835-0s7ok4uw	5552	4	of	of	IN
cord-001835-0s7ok4uw	5552	5	chemical	chemical	NN
cord-001835-0s7ok4uw	5552	6	compounds	compound	NNS
cord-001835-0s7ok4uw	5552	7	were	be	VBD
cord-001835-0s7ok4uw	5552	8	docked	dock	VBN
cord-001835-0s7ok4uw	5552	9	into	into	IN
cord-001835-0s7ok4uw	5552	10	the	the	DT
cord-001835-0s7ok4uw	5552	11	active	active	JJ
cord-001835-0s7ok4uw	5552	12	site	site	NN
cord-001835-0s7ok4uw	5552	13	of	of	IN
cord-001835-0s7ok4uw	5552	14	BpGmhA.	bpgmha.	NN
cord-001835-0s7ok4uw	5553	1	A	a	DT
cord-001835-0s7ok4uw	5553	2	number	number	NN
cord-001835-0s7ok4uw	5553	3	of	of	IN
cord-001835-0s7ok4uw	5553	4	putative	putative	JJ
cord-001835-0s7ok4uw	5553	5	BpGmhA	BpGmhA	NNP
cord-001835-0s7ok4uw	5553	6	binding	binding	NN
cord-001835-0s7ok4uw	5553	7	compounds	compound	NNS
cord-001835-0s7ok4uw	5553	8	better	well	JJR
cord-001835-0s7ok4uw	5553	9	than	than	IN
cord-001835-0s7ok4uw	5553	10	M7P	M7P	NNP
cord-001835-0s7ok4uw	5553	11	were	be	VBD
cord-001835-0s7ok4uw	5553	12	found	find	VBN
cord-001835-0s7ok4uw	5553	13	using	use	VBG
cord-001835-0s7ok4uw	5553	14	Surflex	Surflex	NNP
cord-001835-0s7ok4uw	5553	15	-	-	HYPH
cord-001835-0s7ok4uw	5553	16	Dock	Dock	NNP
cord-001835-0s7ok4uw	5553	17	included	include	VBD
cord-001835-0s7ok4uw	5553	18	in	in	IN
cord-001835-0s7ok4uw	5553	19	the	the	DT
cord-001835-0s7ok4uw	5553	20	SYBYL	SYBYL	NNP
cord-001835-0s7ok4uw	5553	21	software	software	NN
cord-001835-0s7ok4uw	5553	22	package	package	NN
cord-001835-0s7ok4uw	5553	23	.	.	.
cord-001835-0s7ok4uw	5554	1	Characteristics	characteristic	NNS
cord-001835-0s7ok4uw	5554	2	of	of	IN
cord-001835-0s7ok4uw	5554	3	these	these	DT
cord-001835-0s7ok4uw	5554	4	compounds	compound	NNS
cord-001835-0s7ok4uw	5554	5	were	be	VBD
cord-001835-0s7ok4uw	5554	6	surveyed	survey	VBN
cord-001835-0s7ok4uw	5554	7	and	and	CC
cord-001835-0s7ok4uw	5554	8	classified	classify	VBN
cord-001835-0s7ok4uw	5554	9	to	to	TO
cord-001835-0s7ok4uw	5554	10	identify	identify	VB
cord-001835-0s7ok4uw	5554	11	common	common	JJ
cord-001835-0s7ok4uw	5554	12	binding	binding	NN
cord-001835-0s7ok4uw	5554	13	properties	property	NNS
cord-001835-0s7ok4uw	5554	14	with	with	IN
cord-001835-0s7ok4uw	5554	15	BpGmhA.	BpGmhA.	NNP
cord-001835-0s7ok4uw	5554	16	Mapping	map	VBG
cord-001835-0s7ok4uw	5554	17	the	the	DT
cord-001835-0s7ok4uw	5554	18	structure	structure	NN
cord-001835-0s7ok4uw	5554	19	of	of	IN
cord-001835-0s7ok4uw	5554	20	laminin	laminin	NNP
cord-001835-0s7ok4uw	5554	21	using	use	VBG
cord-001835-0s7ok4uw	5554	22	cross	cross	NN
cord-001835-0s7ok4uw	5554	23	-	-	JJ
cord-001835-0s7ok4uw	5554	24	linking	linking	JJ
cord-001835-0s7ok4uw	5554	25	and	and	CC
cord-001835-0s7ok4uw	5554	26	mass	mass	NN
cord-001835-0s7ok4uw	5554	27	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	5554	28	Gad	Gad	NNP
cord-001835-0s7ok4uw	5554	29	Armony	Armony	NNP
cord-001835-0s7ok4uw	5554	30	1	1	CD
cord-001835-0s7ok4uw	5554	31	,	,	,
cord-001835-0s7ok4uw	5554	32	Toot	Toot	NNP
cord-001835-0s7ok4uw	5554	33	Moran	Moran	NNP
cord-001835-0s7ok4uw	5554	34	1	1	CD
cord-001835-0s7ok4uw	5554	35	,	,	,
cord-001835-0s7ok4uw	5554	36	Yishai	Yishai	NNP
cord-001835-0s7ok4uw	5554	37	Levin	Levin	NNP
cord-001835-0s7ok4uw	5554	38	2	2	CD
cord-001835-0s7ok4uw	5554	39	,	,	,
cord-001835-0s7ok4uw	5554	40	Deborah	Deborah	NNP
cord-001835-0s7ok4uw	5554	41	Fass	Fass	NNP
cord-001835-0s7ok4uw	5554	42	1	1	CD
cord-001835-0s7ok4uw	5554	43	1	1	CD
cord-001835-0s7ok4uw	5554	44	Weizmann	Weizmann	NNP
cord-001835-0s7ok4uw	5554	45	Institute	Institute	NNP
cord-001835-0s7ok4uw	5554	46	of	of	IN
cord-001835-0s7ok4uw	5554	47	Science	Science	NNP
cord-001835-0s7ok4uw	5554	48	,	,	,
cord-001835-0s7ok4uw	5554	49	Department	Department	NNP
cord-001835-0s7ok4uw	5554	50	of	of	IN
cord-001835-0s7ok4uw	5554	51	Structural	Structural	NNP
cord-001835-0s7ok4uw	5554	52	Biology	Biology	NNP
cord-001835-0s7ok4uw	5554	53	,	,	,
cord-001835-0s7ok4uw	5554	54	2	2	CD
cord-001835-0s7ok4uw	5554	55	Weizmann	Weizmann	NNP
cord-001835-0s7ok4uw	5554	56	Institute	Institute	NNP
cord-001835-0s7ok4uw	5554	57	of	of	IN
cord-001835-0s7ok4uw	5554	58	Science	Science	NNP
cord-001835-0s7ok4uw	5554	59	,	,	,
cord-001835-0s7ok4uw	5554	60	Israel	Israel	NNP
cord-001835-0s7ok4uw	5554	61	Center	Center	NNP
cord-001835-0s7ok4uw	5554	62	for	for	IN
cord-001835-0s7ok4uw	5554	63	Personalized	Personalized	NNP
cord-001835-0s7ok4uw	5554	64	Medicine	Medicine	NNP
cord-001835-0s7ok4uw	5554	65	Laminin	Laminin	NNP
cord-001835-0s7ok4uw	5554	66	,	,	,
cord-001835-0s7ok4uw	5554	67	a	a	DT
cord-001835-0s7ok4uw	5554	68	800	800	CD
cord-001835-0s7ok4uw	5554	69	kDa	kDa	NNP
cord-001835-0s7ok4uw	5554	70	heterotrimer	heterotrimer	NNP
cord-001835-0s7ok4uw	5554	71	,	,	,
cord-001835-0s7ok4uw	5554	72	is	be	VBZ
cord-001835-0s7ok4uw	5554	73	a	a	DT
cord-001835-0s7ok4uw	5554	74	major	major	JJ
cord-001835-0s7ok4uw	5554	75	element	element	NN
cord-001835-0s7ok4uw	5554	76	in	in	IN
cord-001835-0s7ok4uw	5554	77	the	the	DT
cord-001835-0s7ok4uw	5554	78	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	5554	79	matrix	matrix	NN
cord-001835-0s7ok4uw	5554	80	(	(	-LRB-
cord-001835-0s7ok4uw	5554	81	ECM	ECM	NNP
cord-001835-0s7ok4uw	5554	82	)	)	-RRB-
cord-001835-0s7ok4uw	5554	83	.	.	.
cord-001835-0s7ok4uw	5555	1	Within	within	IN
cord-001835-0s7ok4uw	5555	2	the	the	DT
cord-001835-0s7ok4uw	5555	3	ECM	ECM	NNP
cord-001835-0s7ok4uw	5555	4	,	,	,
cord-001835-0s7ok4uw	5555	5	laminin	laminin	NN
cord-001835-0s7ok4uw	5555	6	contributes	contribute	VBZ
cord-001835-0s7ok4uw	5555	7	to	to	IN
cord-001835-0s7ok4uw	5555	8	the	the	DT
cord-001835-0s7ok4uw	5555	9	adhesion	adhesion	NN
cord-001835-0s7ok4uw	5555	10	and	and	CC
cord-001835-0s7ok4uw	5555	11	migration	migration	NN
cord-001835-0s7ok4uw	5555	12	of	of	IN
cord-001835-0s7ok4uw	5555	13	cells	cell	NNS
cord-001835-0s7ok4uw	5555	14	,	,	,
cord-001835-0s7ok4uw	5555	15	both	both	CC
cord-001835-0s7ok4uw	5555	16	in	in	IN
cord-001835-0s7ok4uw	5555	17	health	health	NN
cord-001835-0s7ok4uw	5555	18	and	and	CC
cord-001835-0s7ok4uw	5555	19	disease	disease	NN
cord-001835-0s7ok4uw	5555	20	.	.	.
cord-001835-0s7ok4uw	5556	1	The	the	DT
cord-001835-0s7ok4uw	5556	2	laminin	laminin	NN
cord-001835-0s7ok4uw	5556	3	trimer	trimer	NN
cord-001835-0s7ok4uw	5556	4	was	be	VBD
cord-001835-0s7ok4uw	5556	5	observed	observe	VBN
cord-001835-0s7ok4uw	5556	6	by	by	IN
cord-001835-0s7ok4uw	5556	7	rotary	rotary	JJ
cord-001835-0s7ok4uw	5556	8	shadowing	shadow	VBG
cord-001835-0s7ok4uw	5556	9	electron	electron	NN
cord-001835-0s7ok4uw	5556	10	microscopy	microscopy	NN
cord-001835-0s7ok4uw	5556	11	to	to	TO
cord-001835-0s7ok4uw	5556	12	be	be	VB
cord-001835-0s7ok4uw	5556	13	cross	cross	JJ
cord-001835-0s7ok4uw	5556	14	shaped	shape	VBN
cord-001835-0s7ok4uw	5556	15	:	:	:
cord-001835-0s7ok4uw	5556	16	the	the	DT
cord-001835-0s7ok4uw	5556	17	three	three	CD
cord-001835-0s7ok4uw	5556	18	short	short	JJ
cord-001835-0s7ok4uw	5556	19	arms	arm	NNS
cord-001835-0s7ok4uw	5556	20	of	of	IN
cord-001835-0s7ok4uw	5556	21	the	the	DT
cord-001835-0s7ok4uw	5556	22	cross	cross	NN
cord-001835-0s7ok4uw	5556	23	are	be	VBP
cord-001835-0s7ok4uw	5556	24	formed	form	VBN
cord-001835-0s7ok4uw	5556	25	by	by	IN
cord-001835-0s7ok4uw	5556	26	the	the	DT
cord-001835-0s7ok4uw	5556	27	amino	amino	NN
cord-001835-0s7ok4uw	5556	28	-	-	HYPH
cord-001835-0s7ok4uw	5556	29	terminal	terminal	NN
cord-001835-0s7ok4uw	5556	30	halves	half	NNS
cord-001835-0s7ok4uw	5556	31	of	of	IN
cord-001835-0s7ok4uw	5556	32	the	the	DT
cord-001835-0s7ok4uw	5556	33	three	three	CD
cord-001835-0s7ok4uw	5556	34	subunits	subunit	NNS
cord-001835-0s7ok4uw	5556	35	,	,	,
cord-001835-0s7ok4uw	5556	36	whereas	whereas	IN
cord-001835-0s7ok4uw	5556	37	the	the	DT
cord-001835-0s7ok4uw	5556	38	long	long	JJ
cord-001835-0s7ok4uw	5556	39	arm	arm	NN
cord-001835-0s7ok4uw	5556	40	of	of	IN
cord-001835-0s7ok4uw	5556	41	the	the	DT
cord-001835-0s7ok4uw	5556	42	cross	cross	NN
cord-001835-0s7ok4uw	5556	43	holds	hold	VBZ
cord-001835-0s7ok4uw	5556	44	the	the	DT
cord-001835-0s7ok4uw	5556	45	three	three	CD
cord-001835-0s7ok4uw	5556	46	chains	chain	NNS
cord-001835-0s7ok4uw	5556	47	together	together	RB
cord-001835-0s7ok4uw	5556	48	in	in	IN
cord-001835-0s7ok4uw	5556	49	a	a	DT
cord-001835-0s7ok4uw	5556	50	long	long	JJ
cord-001835-0s7ok4uw	5556	51	coiled	coiled	JJ
cord-001835-0s7ok4uw	5556	52	coil	coil	NN
cord-001835-0s7ok4uw	5556	53	.	.	.
cord-001835-0s7ok4uw	5557	1	The	the	DT
cord-001835-0s7ok4uw	5557	2	narrow	narrow	JJ
cord-001835-0s7ok4uw	5557	3	and	and	CC
cord-001835-0s7ok4uw	5557	4	flexible	flexible	JJ
cord-001835-0s7ok4uw	5557	5	arms	arm	NNS
cord-001835-0s7ok4uw	5557	6	of	of	IN
cord-001835-0s7ok4uw	5557	7	the	the	DT
cord-001835-0s7ok4uw	5557	8	laminin	laminin	NNP
cord-001835-0s7ok4uw	5557	9	cross	cross	NN
cord-001835-0s7ok4uw	5557	10	complicate	complicate	VB
cord-001835-0s7ok4uw	5557	11	studying	study	VBG
cord-001835-0s7ok4uw	5557	12	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5557	13	structure	structure	NN
cord-001835-0s7ok4uw	5557	14	to	to	IN
cord-001835-0s7ok4uw	5557	15	high	high	JJ
cord-001835-0s7ok4uw	5557	16	resolution	resolution	NN
cord-001835-0s7ok4uw	5557	17	by	by	IN
cord-001835-0s7ok4uw	5557	18	crystallography	crystallography	NN
cord-001835-0s7ok4uw	5557	19	or	or	CC
cord-001835-0s7ok4uw	5557	20	electron	electron	NN
cord-001835-0s7ok4uw	5557	21	microscopy	microscopy	NN
cord-001835-0s7ok4uw	5557	22	single	single	JJ
cord-001835-0s7ok4uw	5557	23	particle	particle	NN
cord-001835-0s7ok4uw	5557	24	reconstruction	reconstruction	NN
cord-001835-0s7ok4uw	5557	25	.	.	.
cord-001835-0s7ok4uw	5558	1	To	to	TO
cord-001835-0s7ok4uw	5558	2	advance	advance	VB
cord-001835-0s7ok4uw	5558	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5558	4	understanding	understanding	NN
cord-001835-0s7ok4uw	5558	5	of	of	IN
cord-001835-0s7ok4uw	5558	6	this	this	DT
cord-001835-0s7ok4uw	5558	7	remarkable	remarkable	JJ
cord-001835-0s7ok4uw	5558	8	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	5558	9	structural	structural	JJ
cord-001835-0s7ok4uw	5558	10	assembly	assembly	NN
cord-001835-0s7ok4uw	5558	11	,	,	,
cord-001835-0s7ok4uw	5558	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	5558	13	have	have	VBP
cord-001835-0s7ok4uw	5558	14	used	use	VBN
cord-001835-0s7ok4uw	5558	15	cross	cross	NN
cord-001835-0s7ok4uw	5558	16	-	-	JJ
cord-001835-0s7ok4uw	5558	17	linking	linking	JJ
cord-001835-0s7ok4uw	5558	18	and	and	CC
cord-001835-0s7ok4uw	5558	19	mass	mass	NN
cord-001835-0s7ok4uw	5558	20	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	5558	21	to	to	TO
cord-001835-0s7ok4uw	5558	22	analyze	analyze	VB
cord-001835-0s7ok4uw	5558	23	the	the	DT
cord-001835-0s7ok4uw	5558	24	organization	organization	NN
cord-001835-0s7ok4uw	5558	25	of	of	IN
cord-001835-0s7ok4uw	5558	26	the	the	DT
cord-001835-0s7ok4uw	5558	27	laminin	laminin	NN
cord-001835-0s7ok4uw	5558	28	trimer	trimer	NN
cord-001835-0s7ok4uw	5558	29	.	.	.
cord-001835-0s7ok4uw	5559	1	This	this	DT
cord-001835-0s7ok4uw	5559	2	technique	technique	NN
cord-001835-0s7ok4uw	5559	3	was	be	VBD
cord-001835-0s7ok4uw	5559	4	validated	validate	VBN
cord-001835-0s7ok4uw	5559	5	by	by	IN
cord-001835-0s7ok4uw	5559	6	known	know	VBN
cord-001835-0s7ok4uw	5559	7	crystal	crystal	NN
cord-001835-0s7ok4uw	5559	8	structures	structure	NNS
cord-001835-0s7ok4uw	5559	9	of	of	IN
cord-001835-0s7ok4uw	5559	10	isolated	isolated	JJ
cord-001835-0s7ok4uw	5559	11	laminin	laminin	NN
cord-001835-0s7ok4uw	5559	12	domains	domain	NNS
cord-001835-0s7ok4uw	5559	13	.	.	.
cord-001835-0s7ok4uw	5560	1	In	in	IN
cord-001835-0s7ok4uw	5560	2	all	all	DT
cord-001835-0s7ok4uw	5560	3	cases	case	NNS
cord-001835-0s7ok4uw	5560	4	the	the	DT
cord-001835-0s7ok4uw	5560	5	crystal	crystal	NN
cord-001835-0s7ok4uw	5560	6	structure	structure	NN
cord-001835-0s7ok4uw	5560	7	distances	distance	NNS
cord-001835-0s7ok4uw	5560	8	agree	agree	VBP
cord-001835-0s7ok4uw	5560	9	with	with	IN
cord-001835-0s7ok4uw	5560	10	the	the	DT
cord-001835-0s7ok4uw	5560	11	cross	cross	JJ
cord-001835-0s7ok4uw	5560	12	-	-	JJ
cord-001835-0s7ok4uw	5560	13	linker	linker	JJ
cord-001835-0s7ok4uw	5560	14	length	length	NN
cord-001835-0s7ok4uw	5560	15	.	.	.
cord-001835-0s7ok4uw	5561	1	The	the	DT
cord-001835-0s7ok4uw	5561	2	identified	identify	VBN
cord-001835-0s7ok4uw	5561	3	cross	cross	NN
cord-001835-0s7ok4uw	5561	4	-	-	NNS
cord-001835-0s7ok4uw	5561	5	links	link	NNS
cord-001835-0s7ok4uw	5561	6	were	be	VBD
cord-001835-0s7ok4uw	5561	7	particularly	particularly	RB
cord-001835-0s7ok4uw	5561	8	helpful	helpful	JJ
cord-001835-0s7ok4uw	5561	9	in	in	IN
cord-001835-0s7ok4uw	5561	10	assigning	assign	VBG
cord-001835-0s7ok4uw	5561	11	the	the	DT
cord-001835-0s7ok4uw	5561	12	register	register	NN
cord-001835-0s7ok4uw	5561	13	and	and	CC
cord-001835-0s7ok4uw	5561	14	the	the	DT
cord-001835-0s7ok4uw	5561	15	subunit	subunit	NN
cord-001835-0s7ok4uw	5561	16	order	order	NN
cord-001835-0s7ok4uw	5561	17	of	of	IN
cord-001835-0s7ok4uw	5561	18	the	the	DT
cord-001835-0s7ok4uw	5561	19	long	long	JJ
cord-001835-0s7ok4uw	5561	20	coiled	coiled	JJ
cord-001835-0s7ok4uw	5561	21	coil	coil	NN
cord-001835-0s7ok4uw	5561	22	due	due	IN
cord-001835-0s7ok4uw	5561	23	to	to	IN
cord-001835-0s7ok4uw	5561	24	the	the	DT
cord-001835-0s7ok4uw	5561	25	high	high	JJ
cord-001835-0s7ok4uw	5561	26	content	content	NN
cord-001835-0s7ok4uw	5561	27	of	of	IN
cord-001835-0s7ok4uw	5561	28	cross	cross	JJ
cord-001835-0s7ok4uw	5561	29	-	-	JJ
cord-001835-0s7ok4uw	5561	30	linkable	linkable	JJ
cord-001835-0s7ok4uw	5561	31	residues	residue	NNS
cord-001835-0s7ok4uw	5561	32	in	in	IN
cord-001835-0s7ok4uw	5561	33	this	this	DT
cord-001835-0s7ok4uw	5561	34	region	region	NN
cord-001835-0s7ok4uw	5561	35	.	.	.
cord-001835-0s7ok4uw	5562	1	Using	use	VBG
cord-001835-0s7ok4uw	5562	2	known	know	VBN
cord-001835-0s7ok4uw	5562	3	X	x	NN
cord-001835-0s7ok4uw	5562	4	-	-	NN
cord-001835-0s7ok4uw	5562	5	ray	ray	NN
cord-001835-0s7ok4uw	5562	6	crystal	crystal	NN
cord-001835-0s7ok4uw	5562	7	structures	structure	NNS
cord-001835-0s7ok4uw	5562	8	,	,	,
cord-001835-0s7ok4uw	5562	9	homology	homology	NN
cord-001835-0s7ok4uw	5562	10	modeling	modeling	NN
cord-001835-0s7ok4uw	5562	11	,	,	,
cord-001835-0s7ok4uw	5562	12	and	and	CC
cord-001835-0s7ok4uw	5562	13	distance	distance	NN
cord-001835-0s7ok4uw	5562	14	restraints	restraint	NNS
cord-001835-0s7ok4uw	5562	15	provided	provide	VBN
cord-001835-0s7ok4uw	5562	16	by	by	IN
cord-001835-0s7ok4uw	5562	17	two	two	CD
cord-001835-0s7ok4uw	5562	18	cross	cross	JJ
cord-001835-0s7ok4uw	5562	19	-	-	JJ
cord-001835-0s7ok4uw	5562	20	linker	linker	JJ
cord-001835-0s7ok4uw	5562	21	chemistries	chemistry	NNS
cord-001835-0s7ok4uw	5562	22	,	,	,
cord-001835-0s7ok4uw	5562	23	a	a	DT
cord-001835-0s7ok4uw	5562	24	clearer	clear	JJR
cord-001835-0s7ok4uw	5562	25	picture	picture	NN
cord-001835-0s7ok4uw	5562	26	of	of	IN
cord-001835-0s7ok4uw	5562	27	the	the	DT
cord-001835-0s7ok4uw	5562	28	laminin	laminin	NN
cord-001835-0s7ok4uw	5562	29	quaternary	quaternary	JJ
cord-001835-0s7ok4uw	5562	30	structure	structure	NN
cord-001835-0s7ok4uw	5562	31	is	be	VBZ
cord-001835-0s7ok4uw	5562	32	obtained	obtain	VBN
cord-001835-0s7ok4uw	5562	33	.	.	.
cord-001835-0s7ok4uw	5563	1	Non	non	JJ
cord-001835-0s7ok4uw	5563	2	-	-	JJ
cord-001835-0s7ok4uw	5563	3	sequential	sequential	JJ
cord-001835-0s7ok4uw	5563	4	protein	protein	NN
cord-001835-0s7ok4uw	5563	5	structure	structure	NN
cord-001835-0s7ok4uw	5563	6	alignment	alignment	NN
cord-001835-0s7ok4uw	5563	7	program	program	NN
cord-001835-0s7ok4uw	5563	8	MICAN	MICAN	NNP
cord-001835-0s7ok4uw	5563	9	and	and	CC
cord-001835-0s7ok4uw	5563	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5563	11	applications	application	NNS
cord-001835-0s7ok4uw	5563	12	Shintaro	Shintaro	NNP
cord-001835-0s7ok4uw	5563	13	Minami	Minami	NNP
cord-001835-0s7ok4uw	5563	14	1	1	CD
cord-001835-0s7ok4uw	5564	1	,	,	,
cord-001835-0s7ok4uw	5564	2	George	George	NNP
cord-001835-0s7ok4uw	5564	3	Chikenji	Chikenji	NNP
cord-001835-0s7ok4uw	5564	4	2	2	CD
cord-001835-0s7ok4uw	5564	5	,	,	,
cord-001835-0s7ok4uw	5564	6	Motonori	Motonori	NNP
cord-001835-0s7ok4uw	5564	7	Ota	Ota	NNP
cord-001835-0s7ok4uw	5564	8	1	1	CD
cord-001835-0s7ok4uw	5564	9	1	1	CD
cord-001835-0s7ok4uw	5564	10	Dept	Dept	NNP
cord-001835-0s7ok4uw	5564	11	.	.	.
cord-001835-0s7ok4uw	5565	1	of	of	IN
cord-001835-0s7ok4uw	5565	2	Info	Info	NNP
cord-001835-0s7ok4uw	5565	3	.	.	.
cord-001835-0s7ok4uw	5566	1	Sci	Sci	NNP
cord-001835-0s7ok4uw	5566	2	.	.	NNP
cord-001835-0s7ok4uw	5566	3	,	,	,
cord-001835-0s7ok4uw	5566	4	Nagoya	Nagoya	NNP
cord-001835-0s7ok4uw	5566	5	Univ	Univ	NNP
cord-001835-0s7ok4uw	5566	6	.	.	NNP
cord-001835-0s7ok4uw	5566	7	,	,	,
cord-001835-0s7ok4uw	5566	8	2	2	CD
cord-001835-0s7ok4uw	5566	9	Dept	Dept	NNP
cord-001835-0s7ok4uw	5566	10	.	.	.
cord-001835-0s7ok4uw	5566	11	of	of	IN
cord-001835-0s7ok4uw	5566	12	Comp	Comp	NNP
cord-001835-0s7ok4uw	5566	13	.	.	.
cord-001835-0s7ok4uw	5567	1	Schi	Schi	NNP
cord-001835-0s7ok4uw	5567	2	.	.	NNP
cord-001835-0s7ok4uw	5567	3	&	&	CC
cord-001835-0s7ok4uw	5567	4	Eng	Eng	NNP
cord-001835-0s7ok4uw	5567	5	.	.	NNP
cord-001835-0s7ok4uw	5567	6	,	,	,
cord-001835-0s7ok4uw	5567	7	Nagoya	Nagoya	NNP
cord-001835-0s7ok4uw	5567	8	Univ	Univ	NNP
cord-001835-0s7ok4uw	5567	9	.	.	.
cord-001835-0s7ok4uw	5568	1	In	in	IN
cord-001835-0s7ok4uw	5568	2	some	some	DT
cord-001835-0s7ok4uw	5568	3	proteins	protein	NNS
cord-001835-0s7ok4uw	5568	4	,	,	,
cord-001835-0s7ok4uw	5568	5	secondary	secondary	JJ
cord-001835-0s7ok4uw	5568	6	structure	structure	NN
cord-001835-0s7ok4uw	5568	7	elements	element	NNS
cord-001835-0s7ok4uw	5568	8	are	be	VBP
cord-001835-0s7ok4uw	5568	9	arranged	arrange	VBN
cord-001835-0s7ok4uw	5568	10	spatially	spatially	RB
cord-001835-0s7ok4uw	5568	11	in	in	IN
cord-001835-0s7ok4uw	5568	12	the	the	DT
cord-001835-0s7ok4uw	5568	13	same	same	JJ
cord-001835-0s7ok4uw	5568	14	manner	manner	NN
cord-001835-0s7ok4uw	5568	15	,	,	,
cord-001835-0s7ok4uw	5568	16	but	but	CC
cord-001835-0s7ok4uw	5568	17	they	-PRON-	PRP
cord-001835-0s7ok4uw	5568	18	are	be	VBP
cord-001835-0s7ok4uw	5568	19	connected	connect	VBN
cord-001835-0s7ok4uw	5568	20	in	in	IN
cord-001835-0s7ok4uw	5568	21	the	the	DT
cord-001835-0s7ok4uw	5568	22	alternative	alternative	JJ
cord-001835-0s7ok4uw	5568	23	ways	way	NNS
cord-001835-0s7ok4uw	5568	24	.	.	.
cord-001835-0s7ok4uw	5569	1	Analysis	analysis	NN
cord-001835-0s7ok4uw	5569	2	on	on	IN
cord-001835-0s7ok4uw	5569	3	such	such	JJ
cord-001835-0s7ok4uw	5569	4	non	non	JJ
cord-001835-0s7ok4uw	5569	5	-	-	JJ
cord-001835-0s7ok4uw	5569	6	sequential	sequential	JJ
cord-001835-0s7ok4uw	5569	7	structural	structural	JJ
cord-001835-0s7ok4uw	5569	8	similarity	similarity	NN
cord-001835-0s7ok4uw	5569	9	in	in	IN
cord-001835-0s7ok4uw	5569	10	proteins	protein	NNS
cord-001835-0s7ok4uw	5569	11	is	be	VBZ
cord-001835-0s7ok4uw	5569	12	important	important	JJ
cord-001835-0s7ok4uw	5569	13	because	because	IN
cord-001835-0s7ok4uw	5569	14	it	-PRON-	PRP
cord-001835-0s7ok4uw	5569	15	provides	provide	VBZ
cord-001835-0s7ok4uw	5569	16	a	a	DT
cord-001835-0s7ok4uw	5569	17	deeper	deep	JJR
cord-001835-0s7ok4uw	5569	18	understanding	understanding	NN
cord-001835-0s7ok4uw	5569	19	of	of	IN
cord-001835-0s7ok4uw	5569	20	the	the	DT
cord-001835-0s7ok4uw	5569	21	structural	structural	JJ
cord-001835-0s7ok4uw	5569	22	geometry	geometry	NN
cord-001835-0s7ok4uw	5569	23	of	of	IN
cord-001835-0s7ok4uw	5569	24	protein	protein	NN
cord-001835-0s7ok4uw	5569	25	.	.	.
cord-001835-0s7ok4uw	5570	1	This	this	DT
cord-001835-0s7ok4uw	5570	2	can	can	MD
cord-001835-0s7ok4uw	5570	3	be	be	VB
cord-001835-0s7ok4uw	5570	4	also	also	RB
cord-001835-0s7ok4uw	5570	5	observed	observe	VBN
cord-001835-0s7ok4uw	5570	6	even	even	RB
cord-001835-0s7ok4uw	5570	7	in	in	IN
cord-001835-0s7ok4uw	5570	8	the	the	DT
cord-001835-0s7ok4uw	5570	9	homologous	homologous	JJ
cord-001835-0s7ok4uw	5570	10	proteins	protein	NNS
cord-001835-0s7ok4uw	5570	11	,	,	,
cord-001835-0s7ok4uw	5570	12	indicating	indicate	VBG
cord-001835-0s7ok4uw	5570	13	the	the	DT
cord-001835-0s7ok4uw	5570	14	non	non	JJ
cord-001835-0s7ok4uw	5570	15	-	-	JJ
cord-001835-0s7ok4uw	5570	16	sequential	sequential	JJ
cord-001835-0s7ok4uw	5570	17	structural	structural	JJ
cord-001835-0s7ok4uw	5570	18	similarity	similarity	NN
cord-001835-0s7ok4uw	5570	19	is	be	VBZ
cord-001835-0s7ok4uw	5570	20	significant	significant	JJ
cord-001835-0s7ok4uw	5570	21	in	in	IN
cord-001835-0s7ok4uw	5570	22	the	the	DT
cord-001835-0s7ok4uw	5570	23	protein	protein	NN
cord-001835-0s7ok4uw	5570	24	evolution	evolution	NN
cord-001835-0s7ok4uw	5570	25	.	.	.
cord-001835-0s7ok4uw	5571	1	However	however	RB
cord-001835-0s7ok4uw	5571	2	,	,	,
cord-001835-0s7ok4uw	5571	3	the	the	DT
cord-001835-0s7ok4uw	5571	4	non	non	JJ
cord-001835-0s7ok4uw	5571	5	-	-	JJ
cord-001835-0s7ok4uw	5571	6	sequential	sequential	JJ
cord-001835-0s7ok4uw	5571	7	structural	structural	JJ
cord-001835-0s7ok4uw	5571	8	similarity	similarity	NN
cord-001835-0s7ok4uw	5571	9	in	in	IN
cord-001835-0s7ok4uw	5571	10	proteins	protein	NNS
cord-001835-0s7ok4uw	5571	11	is	be	VBZ
cord-001835-0s7ok4uw	5571	12	less	less	RBR
cord-001835-0s7ok4uw	5571	13	investigated	investigate	VBN
cord-001835-0s7ok4uw	5571	14	.	.	.
cord-001835-0s7ok4uw	5572	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5572	2	developed	develop	VBD
cord-001835-0s7ok4uw	5572	3	a	a	DT
cord-001835-0s7ok4uw	5572	4	novel	novel	JJ
cord-001835-0s7ok4uw	5572	5	non	non	JJ
cord-001835-0s7ok4uw	5572	6	-	-	JJ
cord-001835-0s7ok4uw	5572	7	sequential	sequential	JJ
cord-001835-0s7ok4uw	5572	8	structural	structural	JJ
cord-001835-0s7ok4uw	5572	9	alignment	alignment	NN
cord-001835-0s7ok4uw	5572	10	program	program	NN
cord-001835-0s7ok4uw	5572	11	MICAN	MICAN	NNP
cord-001835-0s7ok4uw	5572	12	,	,	,
cord-001835-0s7ok4uw	5572	13	which	which	WDT
cord-001835-0s7ok4uw	5572	14	can	can	MD
cord-001835-0s7ok4uw	5572	15	handle	handle	VB
cord-001835-0s7ok4uw	5572	16	Multiple	multiple	JJ
cord-001835-0s7ok4uw	5572	17	chains	chain	NNS
cord-001835-0s7ok4uw	5572	18	,	,	,
cord-001835-0s7ok4uw	5572	19	Inverse	inverse	JJ
cord-001835-0s7ok4uw	5572	20	direction	direction	NN
cord-001835-0s7ok4uw	5572	21	of	of	IN
cord-001835-0s7ok4uw	5572	22	chains	chain	NNS
cord-001835-0s7ok4uw	5572	23	,	,	,
cord-001835-0s7ok4uw	5572	24	C$	c$	$
cord-001835-0s7ok4uw	5572	25	lpha$models	lpha$models	NNP
cord-001835-0s7ok4uw	5572	26	,	,	,
cord-001835-0s7ok4uw	5572	27	Alternative	alternative	JJ
cord-001835-0s7ok4uw	5572	28	alignments	alignment	NNS
cord-001835-0s7ok4uw	5572	29	,	,	,
cord-001835-0s7ok4uw	5572	30	and	and	CC
cord-001835-0s7ok4uw	5572	31	Non	non	JJ
cord-001835-0s7ok4uw	5572	32	-	-	JJ
cord-001835-0s7ok4uw	5572	33	sequential	sequential	JJ
cord-001835-0s7ok4uw	5572	34	alignments	alignment	NNS
cord-001835-0s7ok4uw	5572	35	.	.	.
cord-001835-0s7ok4uw	5573	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5573	2	performed	perform	VBD
cord-001835-0s7ok4uw	5573	3	comprehensive	comprehensive	JJ
cord-001835-0s7ok4uw	5573	4	non	non	JJ
cord-001835-0s7ok4uw	5573	5	-	-	JJ
cord-001835-0s7ok4uw	5573	6	sequential	sequential	JJ
cord-001835-0s7ok4uw	5573	7	structural	structural	JJ
cord-001835-0s7ok4uw	5573	8	comparison	comparison	NN
cord-001835-0s7ok4uw	5573	9	among	among	IN
cord-001835-0s7ok4uw	5573	10	homologous	homologous	JJ
cord-001835-0s7ok4uw	5573	11	proteins	protein	NNS
cord-001835-0s7ok4uw	5573	12	in	in	IN
cord-001835-0s7ok4uw	5573	13	the	the	DT
cord-001835-0s7ok4uw	5573	14	same	same	JJ
cord-001835-0s7ok4uw	5573	15	SCOP	SCOP	NNP
cord-001835-0s7ok4uw	5573	16	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5573	17	by	by	IN
cord-001835-0s7ok4uw	5573	18	using	use	VBG
cord-001835-0s7ok4uw	5573	19	the	the	DT
cord-001835-0s7ok4uw	5573	20	MICAN	MICAN	NNP
cord-001835-0s7ok4uw	5573	21	program	program	NN
cord-001835-0s7ok4uw	5573	22	.	.	.
cord-001835-0s7ok4uw	5574	1	Based	base	VBN
cord-001835-0s7ok4uw	5574	2	on	on	IN
cord-001835-0s7ok4uw	5574	3	the	the	DT
cord-001835-0s7ok4uw	5574	4	result	result	NN
cord-001835-0s7ok4uw	5574	5	,	,	,
cord-001835-0s7ok4uw	5574	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	5574	7	found	find	VBD
cord-001835-0s7ok4uw	5574	8	that	that	IN
cord-001835-0s7ok4uw	5574	9	approximately	approximately	RB
cord-001835-0s7ok4uw	5574	10	8	8	CD
cord-001835-0s7ok4uw	5574	11	%	%	NN
cord-001835-0s7ok4uw	5574	12	of	of	IN
cord-001835-0s7ok4uw	5574	13	superfamilies	superfamily	NNS
cord-001835-0s7ok4uw	5574	14	include	include	VBP
cord-001835-0s7ok4uw	5574	15	at	at	RB
cord-001835-0s7ok4uw	5574	16	least	least	RBS
cord-001835-0s7ok4uw	5574	17	one	one	CD
cord-001835-0s7ok4uw	5574	18	protein	protein	NN
cord-001835-0s7ok4uw	5574	19	pairs	pair	NNS
cord-001835-0s7ok4uw	5574	20	showing	show	VBG
cord-001835-0s7ok4uw	5574	21	non	non	JJ
cord-001835-0s7ok4uw	5574	22	-	-	JJ
cord-001835-0s7ok4uw	5574	23	sequential	sequential	JJ
cord-001835-0s7ok4uw	5574	24	structural	structural	JJ
cord-001835-0s7ok4uw	5574	25	similarity	similarity	NN
cord-001835-0s7ok4uw	5574	26	.	.	.
cord-001835-0s7ok4uw	5575	1	85	85	CD
cord-001835-0s7ok4uw	5575	2	%	%	NN
cord-001835-0s7ok4uw	5575	3	nonsequential	nonsequential	JJ
cord-001835-0s7ok4uw	5575	4	structurally	structurally	RB
cord-001835-0s7ok4uw	5575	5	similar	similar	JJ
cord-001835-0s7ok4uw	5575	6	pairs	pair	NNS
cord-001835-0s7ok4uw	5576	1	are	be	VBP
cord-001835-0s7ok4uw	5576	2	aligned	align	VBN
cord-001835-0s7ok4uw	5576	3	in	in	IN
cord-001835-0s7ok4uw	5576	4	a	a	DT
cord-001835-0s7ok4uw	5576	5	simple	simple	JJ
cord-001835-0s7ok4uw	5576	6	way	way	NN
cord-001835-0s7ok4uw	5576	7	,	,	,
cord-001835-0s7ok4uw	5576	8	e.g.	e.g.	DT
cord-001835-0s7ok4uw	5576	9	circular	circular	JJ
cord-001835-0s7ok4uw	5576	10	permutation	permutation	NN
cord-001835-0s7ok4uw	5576	11	,	,	,
cord-001835-0s7ok4uw	5576	12	$	$	$
cord-001835-0s7ok4uw	5576	13	$strand	$strand	CD
cord-001835-0s7ok4uw	5576	14	flip/	flip/	CD
cord-001835-0s7ok4uw	5576	15	swap	swap	NN
cord-001835-0s7ok4uw	5576	16	,	,	,
cord-001835-0s7ok4uw	5576	17	but	but	CC
cord-001835-0s7ok4uw	5576	18	15	15	CD
cord-001835-0s7ok4uw	5576	19	%	%	NN
cord-001835-0s7ok4uw	5576	20	are	be	VBP
cord-001835-0s7ok4uw	5576	21	complicated	complicated	JJ
cord-001835-0s7ok4uw	5576	22	.	.	.
cord-001835-0s7ok4uw	5577	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	5577	2	,	,	,
cord-001835-0s7ok4uw	5577	3	most	most	JJS
cord-001835-0s7ok4uw	5577	4	of	of	IN
cord-001835-0s7ok4uw	5577	5	such	such	JJ
cord-001835-0s7ok4uw	5577	6	complicated	complicated	JJ
cord-001835-0s7ok4uw	5577	7	non	non	JJ
cord-001835-0s7ok4uw	5577	8	-	-	JJ
cord-001835-0s7ok4uw	5577	9	sequential	sequential	JJ
cord-001835-0s7ok4uw	5577	10	similarities	similarity	NNS
cord-001835-0s7ok4uw	5577	11	can	can	MD
cord-001835-0s7ok4uw	5577	12	be	be	VB
cord-001835-0s7ok4uw	5577	13	explicable	explicable	JJ
cord-001835-0s7ok4uw	5577	14	by	by	IN
cord-001835-0s7ok4uw	5577	15	combination	combination	NN
cord-001835-0s7ok4uw	5577	16	of	of	IN
cord-001835-0s7ok4uw	5577	17	2	2	CD
cord-001835-0s7ok4uw	5577	18	-	-	SYM
cord-001835-0s7ok4uw	5577	19	4	4	CD
cord-001835-0s7ok4uw	5577	20	simple	simple	JJ
cord-001835-0s7ok4uw	5577	21	non	non	JJ
cord-001835-0s7ok4uw	5577	22	-	-	JJ
cord-001835-0s7ok4uw	5577	23	sequential	sequential	JJ
cord-001835-0s7ok4uw	5577	24	relationships	relationship	NNS
cord-001835-0s7ok4uw	5577	25	.	.	.
cord-001835-0s7ok4uw	5578	1	This	this	DT
cord-001835-0s7ok4uw	5578	2	result	result	NN
cord-001835-0s7ok4uw	5578	3	indicates	indicate	VBZ
cord-001835-0s7ok4uw	5578	4	that	that	IN
cord-001835-0s7ok4uw	5578	5	accumulation	accumulation	NN
cord-001835-0s7ok4uw	5578	6	of	of	IN
cord-001835-0s7ok4uw	5578	7	simple	simple	JJ
cord-001835-0s7ok4uw	5578	8	structural	structural	JJ
cord-001835-0s7ok4uw	5578	9	changes	change	NNS
cord-001835-0s7ok4uw	5578	10	in	in	IN
cord-001835-0s7ok4uw	5578	11	the	the	DT
cord-001835-0s7ok4uw	5578	12	course	course	NN
cord-001835-0s7ok4uw	5578	13	of	of	IN
cord-001835-0s7ok4uw	5578	14	protein	protein	NN
cord-001835-0s7ok4uw	5578	15	evolution	evolution	NN
cord-001835-0s7ok4uw	5578	16	produces	produce	VBZ
cord-001835-0s7ok4uw	5578	17	completely	completely	RB
cord-001835-0s7ok4uw	5578	18	different	different	JJ
cord-001835-0s7ok4uw	5578	19	fold	fold	JJ
cord-001835-0s7ok4uw	5578	20	homologs	homolog	NNS
cord-001835-0s7ok4uw	5578	21	.	.	.
cord-001835-0s7ok4uw	5578	22	 	 	_SP
cord-001835-0s7ok4uw	5579	1	As	as	RB
cord-001835-0s7ok4uw	5579	2	early	early	RB
cord-001835-0s7ok4uw	5579	3	as	as	IN
cord-001835-0s7ok4uw	5579	4	1919	1919	CD
cord-001835-0s7ok4uw	5579	5	,	,	,
cord-001835-0s7ok4uw	5579	6	Ritter	Ritter	NNP
cord-001835-0s7ok4uw	5579	7	surmised	surmise	VBD
cord-001835-0s7ok4uw	5579	8	that	that	IN
cord-001835-0s7ok4uw	5579	9	the	the	DT
cord-001835-0s7ok4uw	5579	10	cell	cell	NN
cord-001835-0s7ok4uw	5579	11	's	's	POS
cord-001835-0s7ok4uw	5579	12	molecules	molecule	NNS
cord-001835-0s7ok4uw	5579	13	cooperate	cooperate	VBP
cord-001835-0s7ok4uw	5579	14	to	to	TO
cord-001835-0s7ok4uw	5579	15	form	form	VB
cord-001835-0s7ok4uw	5579	16	a	a	DT
cord-001835-0s7ok4uw	5579	17	"	"	``
cord-001835-0s7ok4uw	5579	18	special	special	JJ
cord-001835-0s7ok4uw	5579	19	apparatus	apparatus	NN
cord-001835-0s7ok4uw	5579	20	and	and	CC
cord-001835-0s7ok4uw	5579	21	an	an	DT
cord-001835-0s7ok4uw	5579	22	organised	organised	JJ
cord-001835-0s7ok4uw	5579	23	laboratory	laboratory	NN
cord-001835-0s7ok4uw	5579	24	"	"	''
cord-001835-0s7ok4uw	5579	25	.	.	.
cord-001835-0s7ok4uw	5580	1	1	1	LS
cord-001835-0s7ok4uw	5581	1	Despite	despite	IN
cord-001835-0s7ok4uw	5581	2	supporting	support	VBG
cord-001835-0s7ok4uw	5581	3	evidence	evidence	NN
cord-001835-0s7ok4uw	5581	4	from	from	IN
cord-001835-0s7ok4uw	5581	5	Srere	Srere	NNP
cord-001835-0s7ok4uw	5581	6	,	,	,
cord-001835-0s7ok4uw	5581	7	McConkey	McConkey	NNP
cord-001835-0s7ok4uw	5581	8	and	and	CC
cord-001835-0s7ok4uw	5581	9	others	other	NNS
cord-001835-0s7ok4uw	5581	10	,	,	,
cord-001835-0s7ok4uw	5581	11	efforts	effort	NNS
cord-001835-0s7ok4uw	5581	12	to	to	TO
cord-001835-0s7ok4uw	5581	13	understand	understand	VB
cord-001835-0s7ok4uw	5581	14	molecular	molecular	JJ
cord-001835-0s7ok4uw	5581	15	organisation	organisation	NN
cord-001835-0s7ok4uw	5581	16	in	in	IN
cord-001835-0s7ok4uw	5581	17	vivo	vivo	NNP
cord-001835-0s7ok4uw	5581	18	are	be	VBP
cord-001835-0s7ok4uw	5581	19	still	still	RB
cord-001835-0s7ok4uw	5581	20	in	in	IN
cord-001835-0s7ok4uw	5581	21	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5581	22	infancy	infancy	NN
cord-001835-0s7ok4uw	5581	23	.	.	.
cord-001835-0s7ok4uw	5582	1	However	however	RB
cord-001835-0s7ok4uw	5582	2	,	,	,
cord-001835-0s7ok4uw	5582	3	important	important	JJ
cord-001835-0s7ok4uw	5582	4	aspects	aspect	NNS
cord-001835-0s7ok4uw	5582	5	of	of	IN
cord-001835-0s7ok4uw	5582	6	the	the	DT
cord-001835-0s7ok4uw	5582	7	cell	cell	NN
cord-001835-0s7ok4uw	5582	8	interior	interior	NN
cord-001835-0s7ok4uw	5582	9	have	have	VBP
cord-001835-0s7ok4uw	5582	10	already	already	RB
cord-001835-0s7ok4uw	5582	11	been	be	VBN
cord-001835-0s7ok4uw	5582	12	revealed	reveal	VBN
cord-001835-0s7ok4uw	5582	13	.	.	.
cord-001835-0s7ok4uw	5583	1	For	for	IN
cord-001835-0s7ok4uw	5583	2	example	example	NN
cord-001835-0s7ok4uw	5583	3	,	,	,
cord-001835-0s7ok4uw	5583	4	weak	weak	JJ
cord-001835-0s7ok4uw	5583	5	molecular	molecular	JJ
cord-001835-0s7ok4uw	5583	6	interactions	interaction	NNS
cord-001835-0s7ok4uw	5583	7	structure	structure	VBP
cord-001835-0s7ok4uw	5583	8	the	the	DT
cord-001835-0s7ok4uw	5583	9	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	5583	10	into	into	IN
cord-001835-0s7ok4uw	5583	11	time	time	NN
cord-001835-0s7ok4uw	5583	12	-	-	HYPH
cord-001835-0s7ok4uw	5583	13	evolving	evolve	VBG
cord-001835-0s7ok4uw	5583	14	,	,	,
cord-001835-0s7ok4uw	5583	15	functional	functional	JJ
cord-001835-0s7ok4uw	5583	16	zones	zone	NNS
cord-001835-0s7ok4uw	5583	17	.	.	.
cord-001835-0s7ok4uw	5584	1	2	2	LS
cord-001835-0s7ok4uw	5585	1	Weak	weak	JJ
cord-001835-0s7ok4uw	5585	2	interactions	interaction	NNS
cord-001835-0s7ok4uw	5585	3	are	be	VBP
cord-001835-0s7ok4uw	5585	4	difficult	difficult	JJ
cord-001835-0s7ok4uw	5585	5	to	to	TO
cord-001835-0s7ok4uw	5585	6	capture	capture	VB
cord-001835-0s7ok4uw	5585	7	and	and	CC
cord-001835-0s7ok4uw	5585	8	can	can	MD
cord-001835-0s7ok4uw	5585	9	preclude	preclude	VB
cord-001835-0s7ok4uw	5585	10	protein	protein	NN
cord-001835-0s7ok4uw	5585	11	detection	detection	NN
cord-001835-0s7ok4uw	5585	12	in	in	IN
cord-001835-0s7ok4uw	5585	13	cells	cell	NNS
cord-001835-0s7ok4uw	5585	14	by	by	IN
cord-001835-0s7ok4uw	5585	15	many	many	JJ
cord-001835-0s7ok4uw	5585	16	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	5585	17	techniques	technique	NNS
cord-001835-0s7ok4uw	5585	18	,	,	,
cord-001835-0s7ok4uw	5585	19	including	include	VBG
cord-001835-0s7ok4uw	5585	20	NMR	NMR	NNP
cord-001835-0s7ok4uw	5585	21	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	5585	22	.	.	.
cord-001835-0s7ok4uw	5586	1	3	3	LS
cord-001835-0s7ok4uw	5586	2	,	,	,
cord-001835-0s7ok4uw	5586	3	4	4	CD
cord-001835-0s7ok4uw	5586	4	We	-PRON-	PRP
cord-001835-0s7ok4uw	5586	5	explored	explore	VBD
cord-001835-0s7ok4uw	5586	6	the	the	DT
cord-001835-0s7ok4uw	5586	7	effects	effect	NNS
cord-001835-0s7ok4uw	5586	8	of	of	IN
cord-001835-0s7ok4uw	5586	9	cell	cell	NN
cord-001835-0s7ok4uw	5586	10	-	-	HYPH
cord-001835-0s7ok4uw	5586	11	like	like	JJ
cord-001835-0s7ok4uw	5586	12	milieus	milieu	NNS
cord-001835-0s7ok4uw	5586	13	on	on	IN
cord-001835-0s7ok4uw	5586	14	the	the	DT
cord-001835-0s7ok4uw	5586	15	cytochrome	cytochrome	NN
cord-001835-0s7ok4uw	5586	16	c	c	NN
cord-001835-0s7ok4uw	5586	17	(	(	-LRB-
cord-001835-0s7ok4uw	5586	18	cyt	cyt	NNP
cord-001835-0s7ok4uw	5586	19	c)-flavodoxin	c)-flavodoxin	ADD
cord-001835-0s7ok4uw	5586	20	(	(	-LRB-
cord-001835-0s7ok4uw	5586	21	fld	fld	NN
cord-001835-0s7ok4uw	5586	22	)	)	-RRB-
cord-001835-0s7ok4uw	5586	23	interaction	interaction	NN
cord-001835-0s7ok4uw	5586	24	.	.	.
cord-001835-0s7ok4uw	5587	1	These	these	DT
cord-001835-0s7ok4uw	5587	2	oppositely	oppositely	RB
cord-001835-0s7ok4uw	5587	3	charged	charge	VBN
cord-001835-0s7ok4uw	5587	4	proteins	protein	NNS
cord-001835-0s7ok4uw	5587	5	interact	interact	VBP
cord-001835-0s7ok4uw	5587	6	weakly	weakly	RB
cord-001835-0s7ok4uw	5587	7	with	with	IN
cord-001835-0s7ok4uw	5587	8	a	a	DT
cord-001835-0s7ok4uw	5587	9	number	number	NN
cord-001835-0s7ok4uw	5587	10	of	of	IN
cord-001835-0s7ok4uw	5587	11	cognate	cognate	JJ
cord-001835-0s7ok4uw	5587	12	partners	partner	NNS
cord-001835-0s7ok4uw	5587	13	.	.	.
cord-001835-0s7ok4uw	5588	1	Neither	neither	DT
cord-001835-0s7ok4uw	5588	2	cyt	cyt	NN
cord-001835-0s7ok4uw	5588	3	c4	c4	NN
cord-001835-0s7ok4uw	5588	4	nor	nor	CC
cord-001835-0s7ok4uw	5588	5	fld	fld	NN
cord-001835-0s7ok4uw	5588	6	is	be	VBZ
cord-001835-0s7ok4uw	5588	7	detectable	detectable	JJ
cord-001835-0s7ok4uw	5588	8	by	by	IN
cord-001835-0s7ok4uw	5588	9	NMR	NMR	NNP
cord-001835-0s7ok4uw	5588	10	in	in	IN
cord-001835-0s7ok4uw	5588	11	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	5588	12	coli	coli	NNS
cord-001835-0s7ok4uw	5588	13	confirming	confirm	VBG
cord-001835-0s7ok4uw	5588	14	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5588	15	"	"	``
cord-001835-0s7ok4uw	5588	16	sticky	sticky	JJ
cord-001835-0s7ok4uw	5588	17	"	"	''
cord-001835-0s7ok4uw	5588	18	nature	nature	NN
cord-001835-0s7ok4uw	5588	19	(	(	-LRB-
cord-001835-0s7ok4uw	5588	20	Figure	figure	NN
cord-001835-0s7ok4uw	5588	21	1A	1a	NN
cord-001835-0s7ok4uw	5588	22	)	)	-RRB-
cord-001835-0s7ok4uw	5588	23	.	.	.
cord-001835-0s7ok4uw	5589	1	The	the	DT
cord-001835-0s7ok4uw	5589	2	cyt	cyt	NN
cord-001835-0s7ok4uw	5589	3	c	c	NN
cord-001835-0s7ok4uw	5589	4	-	-	HYPH
cord-001835-0s7ok4uw	5589	5	fld	fld	NN
cord-001835-0s7ok4uw	5589	6	interaction	interaction	NN
cord-001835-0s7ok4uw	5589	7	was	be	VBD
cord-001835-0s7ok4uw	5589	8	assessed	assess	VBN
cord-001835-0s7ok4uw	5589	9	in	in	IN
cord-001835-0s7ok4uw	5589	10	buffer	buffer	NN
cord-001835-0s7ok4uw	5589	11	,	,	,
cord-001835-0s7ok4uw	5589	12	8	8	CD
cord-001835-0s7ok4uw	5589	13	%	%	NN
cord-001835-0s7ok4uw	5589	14	polyacrylamide	polyacrylamide	NN
cord-001835-0s7ok4uw	5589	15	gels	gel	NNS
cord-001835-0s7ok4uw	5589	16	and	and	CC
cord-001835-0s7ok4uw	5589	17	in	in	IN
cord-001835-0s7ok4uw	5589	18	solutions	solution	NNS
cord-001835-0s7ok4uw	5589	19	containing	contain	VBG
cord-001835-0s7ok4uw	5589	20	100	100	CD
cord-001835-0s7ok4uw	5589	21	g	g	NN
cord-001835-0s7ok4uw	5589	22	/	/	SYM
cord-001835-0s7ok4uw	5589	23	L	L	NNP
cord-001835-0s7ok4uw	5589	24	of	of	IN
cord-001835-0s7ok4uw	5589	25	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	5589	26	crowders	crowder	NNS
cord-001835-0s7ok4uw	5589	27	(	(	-LRB-
cord-001835-0s7ok4uw	5589	28	Figure	figure	NN
cord-001835-0s7ok4uw	5589	29	1B	1b	CD
cord-001835-0s7ok4uw	5589	30	)	)	-RRB-
cord-001835-0s7ok4uw	5589	31	.	.	.
cord-001835-0s7ok4uw	5590	1	1H	1H	NNP
cord-001835-0s7ok4uw	5590	2	,	,	,
cord-001835-0s7ok4uw	5590	3	15N	15n	CD
cord-001835-0s7ok4uw	5590	4	HSQC	HSQC	NNP
cord-001835-0s7ok4uw	5590	5	NMR	NMR	NNP
cord-001835-0s7ok4uw	5590	6	revealed	reveal	VBD
cord-001835-0s7ok4uw	5590	7	that	that	IN
cord-001835-0s7ok4uw	5590	8	the	the	DT
cord-001835-0s7ok4uw	5590	9	interaction	interaction	NN
cord-001835-0s7ok4uw	5590	10	was	be	VBD
cord-001835-0s7ok4uw	5590	11	transient	transient	JJ
cord-001835-0s7ok4uw	5590	12	in	in	IN
cord-001835-0s7ok4uw	5590	13	buffer	buffer	NN
cord-001835-0s7ok4uw	5590	14	,	,	,
cord-001835-0s7ok4uw	5590	15	proceeding	proceed	VBG
cord-001835-0s7ok4uw	5590	16	via	via	IN
cord-001835-0s7ok4uw	5590	17	the	the	DT
cord-001835-0s7ok4uw	5590	18	known	know	VBN
cord-001835-0s7ok4uw	5590	19	binding	binding	NN
cord-001835-0s7ok4uw	5590	20	site	site	NN
cord-001835-0s7ok4uw	5590	21	for	for	IN
cord-001835-0s7ok4uw	5590	22	both	both	DT
cord-001835-0s7ok4uw	5590	23	proteins	protein	NNS
cord-001835-0s7ok4uw	5590	24	.	.	.
cord-001835-0s7ok4uw	5591	1	Substantial	substantial	JJ
cord-001835-0s7ok4uw	5591	2	line	line	NN
cord-001835-0s7ok4uw	5591	3	broadening	broadening	NN
cord-001835-0s7ok4uw	5591	4	was	be	VBD
cord-001835-0s7ok4uw	5591	5	effected	effect	VBN
cord-001835-0s7ok4uw	5591	6	in	in	IN
cord-001835-0s7ok4uw	5591	7	crowded	crowded	JJ
cord-001835-0s7ok4uw	5591	8	and	and	CC
cord-001835-0s7ok4uw	5591	9	confined	confine	VBN
cord-001835-0s7ok4uw	5591	10	solutions	solution	NNS
cord-001835-0s7ok4uw	5591	11	suggesting	suggest	VBG
cord-001835-0s7ok4uw	5591	12	that	that	IN
cord-001835-0s7ok4uw	5591	13	the	the	DT
cord-001835-0s7ok4uw	5591	14	cyt	cyt	NN
cord-001835-0s7ok4uw	5591	15	c	c	NN
cord-001835-0s7ok4uw	5591	16	-	-	HYPH
cord-001835-0s7ok4uw	5591	17	fld	fld	NN
cord-001835-0s7ok4uw	5591	18	complex	complex	NN
cord-001835-0s7ok4uw	5591	19	is	be	VBZ
cord-001835-0s7ok4uw	5591	20	stabilised	stabilise	VBN
cord-001835-0s7ok4uw	5591	21	under	under	IN
cord-001835-0s7ok4uw	5591	22	native	native	JJ
cord-001835-0s7ok4uw	5591	23	-	-	HYPH
cord-001835-0s7ok4uw	5591	24	like	like	JJ
cord-001835-0s7ok4uw	5591	25	conditions	condition	NNS
cord-001835-0s7ok4uw	5591	26	.	.	.
cord-001835-0s7ok4uw	5592	1	The	the	DT
cord-001835-0s7ok4uw	5592	2	stabilising	stabilise	VBG
cord-001835-0s7ok4uw	5592	3	effect	effect	NN
cord-001835-0s7ok4uw	5592	4	of	of	IN
cord-001835-0s7ok4uw	5592	5	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	5592	6	crowders	crowder	NNS
cord-001835-0s7ok4uw	5592	7	was	be	VBD
cord-001835-0s7ok4uw	5592	8	also	also	RB
cord-001835-0s7ok4uw	5592	9	observed	observe	VBN
cord-001835-0s7ok4uw	5592	10	by	by	IN
cord-001835-0s7ok4uw	5592	11	native	native	JJ
cord-001835-0s7ok4uw	5592	12	gel	gel	NN
cord-001835-0s7ok4uw	5592	13	electrophoresis	electrophoresis	NN
cord-001835-0s7ok4uw	5592	14	and	and	CC
cord-001835-0s7ok4uw	5592	15	crystallization	crystallization	NN
cord-001835-0s7ok4uw	5592	16	.	.	.
cord-001835-0s7ok4uw	5593	1	These	these	DT
cord-001835-0s7ok4uw	5593	2	findings	finding	NNS
cord-001835-0s7ok4uw	5593	3	coincide	coincide	VBP
cord-001835-0s7ok4uw	5593	4	with	with	IN
cord-001835-0s7ok4uw	5593	5	Spitzer	Spitzer	NNP
cord-001835-0s7ok4uw	5593	6	and	and	CC
cord-001835-0s7ok4uw	5593	7	Poolman	Poolman	NNP
cord-001835-0s7ok4uw	5593	8	's	's	POS
cord-001835-0s7ok4uw	5593	9	model	model	NN
cord-001835-0s7ok4uw	5593	10	for	for	IN
cord-001835-0s7ok4uw	5593	11	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	5593	12	structuring	structuring	NN
cord-001835-0s7ok4uw	5593	13	,	,	,
cord-001835-0s7ok4uw	5593	14	emphasising	emphasise	VBG
cord-001835-0s7ok4uw	5593	15	the	the	DT
cord-001835-0s7ok4uw	5593	16	role	role	NN
cord-001835-0s7ok4uw	5593	17	of	of	IN
cord-001835-0s7ok4uw	5593	18	charge	charge	NN
cord-001835-0s7ok4uw	5593	19	-	-	HYPH
cord-001835-0s7ok4uw	5593	20	charge	charge	NN
cord-001835-0s7ok4uw	5593	21	interactions	interaction	NNS
cord-001835-0s7ok4uw	5593	22	and	and	CC
cord-001835-0s7ok4uw	5593	23	crowding	crowd	VBG
cord-001835-0s7ok4uw	5593	24	in	in	IN
cord-001835-0s7ok4uw	5593	25	the	the	DT
cord-001835-0s7ok4uw	5593	26	formation	formation	NN
cord-001835-0s7ok4uw	5593	27	of	of	IN
cord-001835-0s7ok4uw	5593	28	macromolecular	macromolecular	JJ
cord-001835-0s7ok4uw	5593	29	"	"	``
cord-001835-0s7ok4uw	5593	30	clusters	cluster	NNS
cord-001835-0s7ok4uw	5593	31	"	"	''
cord-001835-0s7ok4uw	5593	32	.	.	.
cord-001835-0s7ok4uw	5594	1	5	5	LS
cord-001835-0s7ok4uw	5595	1	The	the	DT
cord-001835-0s7ok4uw	5595	2	implications	implication	NNS
cord-001835-0s7ok4uw	5595	3	for	for	IN
cord-001835-0s7ok4uw	5595	4	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	5595	5	structuring	structuring	NN
cord-001835-0s7ok4uw	5595	6	will	will	MD
cord-001835-0s7ok4uw	5595	7	be	be	VB
cord-001835-0s7ok4uw	5595	8	discussed	discuss	VBN
cord-001835-0s7ok4uw	5595	9	alongside	alongside	IN
cord-001835-0s7ok4uw	5595	10	related	related	JJ
cord-001835-0s7ok4uw	5595	11	investigations	investigation	NNS
cord-001835-0s7ok4uw	5595	12	of	of	IN
cord-001835-0s7ok4uw	5595	13	cationic	cationic	JJ
cord-001835-0s7ok4uw	5595	14	protein	protein	NN
cord-001835-0s7ok4uw	5595	15	interactions	interaction	NNS
cord-001835-0s7ok4uw	5595	16	in	in	IN
cord-001835-0s7ok4uw	5595	17	E.	E.	NNP
cord-001835-0s7ok4uw	5595	18	coli	coli	NNS
cord-001835-0s7ok4uw	5595	19	extracts	extract	NNS
cord-001835-0s7ok4uw	5595	20	.	.	.
cord-001835-0s7ok4uw	5596	1	3	3	CD
cord-001835-0s7ok4uw	5596	2	,	,	,
cord-001835-0s7ok4uw	5596	3	4	4	CD
cord-001835-0s7ok4uw	5596	4	detergent	detergent	NN
cord-001835-0s7ok4uw	5596	5	:	:	:
cord-001835-0s7ok4uw	5596	6	protein	protein	NN
cord-001835-0s7ok4uw	5596	7	ratio	ratio	NN
cord-001835-0s7ok4uw	5596	8	.	.	.
cord-001835-0s7ok4uw	5597	1	The	the	DT
cord-001835-0s7ok4uw	5597	2	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	5597	3	b	b	NN
cord-001835-0s7ok4uw	5597	4	-	-	HYPH
cord-001835-0s7ok4uw	5597	5	barrel	barrel	NN
cord-001835-0s7ok4uw	5597	6	of	of	IN
cord-001835-0s7ok4uw	5597	7	BamA	BamA	NNP
cord-001835-0s7ok4uw	5597	8	is	be	VBZ
cord-001835-0s7ok4uw	5597	9	folded	fold	VBN
cord-001835-0s7ok4uw	5597	10	in	in	IN
cord-001835-0s7ok4uw	5597	11	either	either	DT
cord-001835-0s7ok4uw	5597	12	micelles	micelle	NNS
cord-001835-0s7ok4uw	5597	13	,	,	,
cord-001835-0s7ok4uw	5597	14	bicelles	bicelle	NNS
cord-001835-0s7ok4uw	5597	15	or	or	CC
cord-001835-0s7ok4uw	5597	16	nanodiscs	nanodiscs	NNP
cord-001835-0s7ok4uw	5597	17	,	,	,
cord-001835-0s7ok4uw	5597	18	however	however	RB
cord-001835-0s7ok4uw	5597	19	an	an	DT
cord-001835-0s7ok4uw	5597	20	N	n	NN
cord-001835-0s7ok4uw	5597	21	-	-	HYPH
cord-001835-0s7ok4uw	5597	22	terminally	terminally	RB
cord-001835-0s7ok4uw	5597	23	attached	attach	VBN
cord-001835-0s7ok4uw	5597	24	single	single	JJ
cord-001835-0s7ok4uw	5597	25	POTRA5	potra5	NN
cord-001835-0s7ok4uw	5597	26	domain	domain	NN
cord-001835-0s7ok4uw	5597	27	is	be	VBZ
cord-001835-0s7ok4uw	5597	28	flexibly	flexibly	RB
cord-001835-0s7ok4uw	5597	29	unfolded	unfold	VBN
cord-001835-0s7ok4uw	5597	30	,	,	,
cord-001835-0s7ok4uw	5597	31	due	due	IN
cord-001835-0s7ok4uw	5597	32	to	to	IN
cord-001835-0s7ok4uw	5597	33	the	the	DT
cord-001835-0s7ok4uw	5597	34	absence	absence	NN
cord-001835-0s7ok4uw	5597	35	of	of	IN
cord-001835-0s7ok4uw	5597	36	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	5597	37	contacts	contact	NNS
cord-001835-0s7ok4uw	5597	38	with	with	IN
cord-001835-0s7ok4uw	5597	39	other	other	JJ
cord-001835-0s7ok4uw	5597	40	protein	protein	NN
cord-001835-0s7ok4uw	5597	41	domains	domain	NNS
cord-001835-0s7ok4uw	5597	42	.	.	.
cord-001835-0s7ok4uw	5598	1	Measurements	measurement	NNS
cord-001835-0s7ok4uw	5598	2	of	of	IN
cord-001835-0s7ok4uw	5598	3	backbone	backbone	NN
cord-001835-0s7ok4uw	5598	4	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	5598	5	show	show	VBP
cord-001835-0s7ok4uw	5598	6	distinct	distinct	JJ
cord-001835-0s7ok4uw	5598	7	time	time	NN
cord-001835-0s7ok4uw	5598	8	scales	scale	NNS
cord-001835-0s7ok4uw	5598	9	of	of	IN
cord-001835-0s7ok4uw	5598	10	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	5598	11	behavior	behavior	NN
cord-001835-0s7ok4uw	5598	12	for	for	IN
cord-001835-0s7ok4uw	5598	13	BamA	BamA	NNP
cord-001835-0s7ok4uw	5598	14	b	b	NN
cord-001835-0s7ok4uw	5598	15	-	-	HYPH
cord-001835-0s7ok4uw	5598	16	barrel	barrel	NN
cord-001835-0s7ok4uw	5598	17	and	and	CC
cord-001835-0s7ok4uw	5598	18	parts	part	NNS
cord-001835-0s7ok4uw	5598	19	of	of	IN
cord-001835-0s7ok4uw	5598	20	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5598	21	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	5598	22	loop	loop	NN
cord-001835-0s7ok4uw	5598	23	L6	l6	NN
cord-001835-0s7ok4uw	5598	24	,	,	,
cord-001835-0s7ok4uw	5598	25	revealing	reveal	VBG
cord-001835-0s7ok4uw	5598	26	high	high	JJ
cord-001835-0s7ok4uw	5598	27	local	local	JJ
cord-001835-0s7ok4uw	5598	28	flexibility	flexibility	NN
cord-001835-0s7ok4uw	5598	29	within	within	IN
cord-001835-0s7ok4uw	5598	30	the	the	DT
cord-001835-0s7ok4uw	5598	31	the	the	DT
cord-001835-0s7ok4uw	5598	32	lid	lid	NN
cord-001835-0s7ok4uw	5598	33	loop	loop	NN
cord-001835-0s7ok4uw	5598	34	.	.	.
cord-001835-0s7ok4uw	5599	1	This	this	DT
cord-001835-0s7ok4uw	5599	2	work	work	NN
cord-001835-0s7ok4uw	5599	3	presents	present	VBZ
cord-001835-0s7ok4uw	5599	4	the	the	DT
cord-001835-0s7ok4uw	5599	5	first	first	JJ
cord-001835-0s7ok4uw	5599	6	high	high	JJ
cord-001835-0s7ok4uw	5599	7	-	-	HYPH
cord-001835-0s7ok4uw	5599	8	resolution	resolution	NN
cord-001835-0s7ok4uw	5599	9	2D	2D	NNP
cord-001835-0s7ok4uw	5599	10	solution	solution	NN
cord-001835-0s7ok4uw	5599	11	NMR	NMR	NNP
cord-001835-0s7ok4uw	5599	12	spectra	spectrum	NNS
cord-001835-0s7ok4uw	5599	13	of	of	IN
cord-001835-0s7ok4uw	5599	14	the	the	DT
cord-001835-0s7ok4uw	5599	15	BamA	BamA	NNP
cord-001835-0s7ok4uw	5599	16	barrel	barrel	NN
cord-001835-0s7ok4uw	5599	17	and	and	CC
cord-001835-0s7ok4uw	5599	18	establishes	establish	VBZ
cord-001835-0s7ok4uw	5599	19	improved	improve	VBN
cord-001835-0s7ok4uw	5599	20	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5599	21	preparation	preparation	NN
cord-001835-0s7ok4uw	5599	22	schemes	scheme	NNS
cord-001835-0s7ok4uw	5599	23	,	,	,
cord-001835-0s7ok4uw	5599	24	which	which	WDT
cord-001835-0s7ok4uw	5599	25	will	will	MD
cord-001835-0s7ok4uw	5599	26	serve	serve	VB
cord-001835-0s7ok4uw	5599	27	as	as	IN
cord-001835-0s7ok4uw	5599	28	a	a	DT
cord-001835-0s7ok4uw	5599	29	platform	platform	NN
cord-001835-0s7ok4uw	5599	30	for	for	IN
cord-001835-0s7ok4uw	5599	31	structural	structural	JJ
cord-001835-0s7ok4uw	5599	32	and	and	CC
cord-001835-0s7ok4uw	5599	33	functional	functional	JJ
cord-001835-0s7ok4uw	5599	34	studies	study	NNS
cord-001835-0s7ok4uw	5599	35	of	of	IN
cord-001835-0s7ok4uw	5599	36	BamA	BamA	NNP
cord-001835-0s7ok4uw	5599	37	and	and	CC
cord-001835-0s7ok4uw	5599	38	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5599	39	role	role	NN
cord-001835-0s7ok4uw	5599	40	within	within	IN
cord-001835-0s7ok4uw	5599	41	the	the	DT
cord-001835-0s7ok4uw	5599	42	Bam	Bam	NNP
cord-001835-0s7ok4uw	5599	43	complex	complex	NN
cord-001835-0s7ok4uw	5599	44	.	.	.
cord-001835-0s7ok4uw	5600	1	Protein	protein	NN
cord-001835-0s7ok4uw	5600	2	arginine	arginine	NN
cord-001835-0s7ok4uw	5600	3	methylation	methylation	NN
cord-001835-0s7ok4uw	5600	4	is	be	VBZ
cord-001835-0s7ok4uw	5600	5	a	a	DT
cord-001835-0s7ok4uw	5600	6	widespread	widespread	JJ
cord-001835-0s7ok4uw	5600	7	and	and	CC
cord-001835-0s7ok4uw	5600	8	important	important	JJ
cord-001835-0s7ok4uw	5600	9	posttranslational	posttranslational	JJ
cord-001835-0s7ok4uw	5600	10	modification	modification	NN
cord-001835-0s7ok4uw	5600	11	in	in	IN
cord-001835-0s7ok4uw	5600	12	eukaryotic	eukaryotic	JJ
cord-001835-0s7ok4uw	5600	13	cells	cell	NNS
cord-001835-0s7ok4uw	5600	14	,	,	,
cord-001835-0s7ok4uw	5600	15	shown	show	VBN
cord-001835-0s7ok4uw	5600	16	to	to	TO
cord-001835-0s7ok4uw	5600	17	be	be	VB
cord-001835-0s7ok4uw	5600	18	involved	involve	VBN
cord-001835-0s7ok4uw	5600	19	in	in	IN
cord-001835-0s7ok4uw	5600	20	the	the	DT
cord-001835-0s7ok4uw	5600	21	activation	activation	NN
cord-001835-0s7ok4uw	5600	22	or	or	CC
cord-001835-0s7ok4uw	5600	23	repression	repression	NN
cord-001835-0s7ok4uw	5600	24	of	of	IN
cord-001835-0s7ok4uw	5600	25	transcription	transcription	NN
cord-001835-0s7ok4uw	5600	26	,	,	,
cord-001835-0s7ok4uw	5600	27	modification	modification	NN
cord-001835-0s7ok4uw	5600	28	of	of	IN
cord-001835-0s7ok4uw	5600	29	the	the	DT
cord-001835-0s7ok4uw	5600	30	splicing	splicing	NN
cord-001835-0s7ok4uw	5600	31	machinery	machinery	NN
cord-001835-0s7ok4uw	5600	32	,	,	,
cord-001835-0s7ok4uw	5600	33	signaling	signal	VBG
cord-001835-0s7ok4uw	5600	34	,	,	,
cord-001835-0s7ok4uw	5600	35	and	and	CC
cord-001835-0s7ok4uw	5600	36	DNA	dna	NN
cord-001835-0s7ok4uw	5600	37	repair	repair	NN
cord-001835-0s7ok4uw	5600	38	.	.	.
cord-001835-0s7ok4uw	5601	1	Mammalian	mammalian	JJ
cord-001835-0s7ok4uw	5601	2	protein	protein	NN
cord-001835-0s7ok4uw	5601	3	arginine	arginine	NN
cord-001835-0s7ok4uw	5601	4	methyltransferases	methyltransferase	NNS
cord-001835-0s7ok4uw	5601	5	include	include	VBP
cord-001835-0s7ok4uw	5601	6	a	a	DT
cord-001835-0s7ok4uw	5601	7	family	family	NN
cord-001835-0s7ok4uw	5601	8	of	of	IN
cord-001835-0s7ok4uw	5601	9	nine	nine	CD
cord-001835-0s7ok4uw	5601	10	sequence	sequence	NN
cord-001835-0s7ok4uw	5601	11	-	-	HYPH
cord-001835-0s7ok4uw	5601	12	related	relate	VBN
cord-001835-0s7ok4uw	5601	13	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5601	14	that	that	WDT
cord-001835-0s7ok4uw	5601	15	transfer	transfer	VBP
cord-001835-0s7ok4uw	5601	16	one	one	CD
cord-001835-0s7ok4uw	5601	17	or	or	CC
cord-001835-0s7ok4uw	5601	18	two	two	CD
cord-001835-0s7ok4uw	5601	19	methyl	methyl	NN
cord-001835-0s7ok4uw	5601	20	groups	group	NNS
cord-001835-0s7ok4uw	5601	21	onto	onto	IN
cord-001835-0s7ok4uw	5601	22	the	the	DT
cord-001835-0s7ok4uw	5601	23	terminal	terminal	JJ
cord-001835-0s7ok4uw	5601	24	guanidino	guanidino	JJ
cord-001835-0s7ok4uw	5601	25	groups	group	NNS
cord-001835-0s7ok4uw	5601	26	on	on	IN
cord-001835-0s7ok4uw	5601	27	arginine	arginine	NN
cord-001835-0s7ok4uw	5601	28	residues	residue	NNS
cord-001835-0s7ok4uw	5601	29	,	,	,
cord-001835-0s7ok4uw	5601	30	producing	produce	VBG
cord-001835-0s7ok4uw	5601	31	monomethylarginine	monomethylarginine	NN
cord-001835-0s7ok4uw	5601	32	only	only	RB
cord-001835-0s7ok4uw	5601	33	(	(	-LRB-
cord-001835-0s7ok4uw	5601	34	MMA	MMA	NNP
cord-001835-0s7ok4uw	5601	35	,	,	,
cord-001835-0s7ok4uw	5601	36	type	type	NN
cord-001835-0s7ok4uw	5601	37	III	III	NNP
cord-001835-0s7ok4uw	5601	38	)	)	-RRB-
cord-001835-0s7ok4uw	5601	39	,	,	,
cord-001835-0s7ok4uw	5601	40	symmetric	symmetric	JJ
cord-001835-0s7ok4uw	5601	41	dimethylarginine	dimethylarginine	JJ
cord-001835-0s7ok4uw	5601	42	(	(	-LRB-
cord-001835-0s7ok4uw	5601	43	SDMA	SDMA	NNP
cord-001835-0s7ok4uw	5601	44	)	)	-RRB-
cord-001835-0s7ok4uw	5601	45	and	and	CC
cord-001835-0s7ok4uw	5601	46	MMA	MMA	NNP
cord-001835-0s7ok4uw	5601	47	(	(	-LRB-
cord-001835-0s7ok4uw	5601	48	Type	Type	NNP
cord-001835-0s7ok4uw	5601	49	II	II	NNP
cord-001835-0s7ok4uw	5601	50	)	)	-RRB-
cord-001835-0s7ok4uw	5601	51	,	,	,
cord-001835-0s7ok4uw	5601	52	or	or	CC
cord-001835-0s7ok4uw	5601	53	asymmetric	asymmetric	JJ
cord-001835-0s7ok4uw	5601	54	dimethylarginine	dimethylarginine	NN
cord-001835-0s7ok4uw	5601	55	(	(	-LRB-
cord-001835-0s7ok4uw	5601	56	ADMA	ADMA	NNP
cord-001835-0s7ok4uw	5601	57	)	)	-RRB-
cord-001835-0s7ok4uw	5601	58	and	and	CC
cord-001835-0s7ok4uw	5601	59	MMA	MMA	NNP
cord-001835-0s7ok4uw	5601	60	(	(	-LRB-
cord-001835-0s7ok4uw	5601	61	Type	type	NN
cord-001835-0s7ok4uw	5601	62	I	I	NNP
cord-001835-0s7ok4uw	5601	63	)	)	-RRB-
cord-001835-0s7ok4uw	5601	64	.	.	.
cord-001835-0s7ok4uw	5602	1	While	while	IN
cord-001835-0s7ok4uw	5602	2	PRMT1	PRMT1	NNP
cord-001835-0s7ok4uw	5602	3	,	,	,
cord-001835-0s7ok4uw	5602	4	2	2	CD
cord-001835-0s7ok4uw	5602	5	,	,	,
cord-001835-0s7ok4uw	5602	6	3	3	CD
cord-001835-0s7ok4uw	5602	7	,	,	,
cord-001835-0s7ok4uw	5602	8	4	4	CD
cord-001835-0s7ok4uw	5602	9	,	,	,
cord-001835-0s7ok4uw	5602	10	6	6	CD
cord-001835-0s7ok4uw	5602	11	,	,	,
cord-001835-0s7ok4uw	5602	12	and	and	CC
cord-001835-0s7ok4uw	5602	13	8	8	CD
cord-001835-0s7ok4uw	5602	14	have	have	VBP
cord-001835-0s7ok4uw	5602	15	been	be	VBN
cord-001835-0s7ok4uw	5602	16	characterized	characterize	VBN
cord-001835-0s7ok4uw	5602	17	as	as	IN
cord-001835-0s7ok4uw	5602	18	type	type	NN
cord-001835-0s7ok4uw	5602	19	I	-PRON-	PRP
cord-001835-0s7ok4uw	5602	20	enzymes	enzyme	VBZ
cord-001835-0s7ok4uw	5602	21	,	,	,
cord-001835-0s7ok4uw	5602	22	and	and	CC
cord-001835-0s7ok4uw	5602	23	PRMT5	PRMT5	NNS
cord-001835-0s7ok4uw	5602	24	as	as	IN
cord-001835-0s7ok4uw	5602	25	a	a	DT
cord-001835-0s7ok4uw	5602	26	type	type	NN
cord-001835-0s7ok4uw	5602	27	II	II	NNP
cord-001835-0s7ok4uw	5602	28	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5602	29	,	,	,
cord-001835-0s7ok4uw	5602	30	the	the	DT
cord-001835-0s7ok4uw	5602	31	role	role	NN
cord-001835-0s7ok4uw	5602	32	and	and	CC
cord-001835-0s7ok4uw	5602	33	activity	activity	NN
cord-001835-0s7ok4uw	5602	34	types	type	NNS
cord-001835-0s7ok4uw	5602	35	of	of	IN
cord-001835-0s7ok4uw	5602	36	the	the	DT
cord-001835-0s7ok4uw	5602	37	two	two	CD
cord-001835-0s7ok4uw	5602	38	final	final	JJ
cord-001835-0s7ok4uw	5602	39	members	member	NNS
cord-001835-0s7ok4uw	5602	40	of	of	IN
cord-001835-0s7ok4uw	5602	41	this	this	DT
cord-001835-0s7ok4uw	5602	42	family	family	NN
cord-001835-0s7ok4uw	5602	43	of	of	IN
cord-001835-0s7ok4uw	5602	44	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5602	45	,	,	,
cord-001835-0s7ok4uw	5602	46	PRMT7	prmt7	NN
cord-001835-0s7ok4uw	5602	47	and	and	CC
cord-001835-0s7ok4uw	5602	48	PRMT9	PRMT9	NNP
cord-001835-0s7ok4uw	5602	49	,	,	,
cord-001835-0s7ok4uw	5602	50	had	have	VBD
cord-001835-0s7ok4uw	5602	51	been	be	VBN
cord-001835-0s7ok4uw	5602	52	unclear	unclear	JJ
cord-001835-0s7ok4uw	5602	53	due	due	IN
cord-001835-0s7ok4uw	5602	54	to	to	IN
cord-001835-0s7ok4uw	5602	55	conflicting	conflicting	JJ
cord-001835-0s7ok4uw	5602	56	results	result	NNS
cord-001835-0s7ok4uw	5602	57	in	in	IN
cord-001835-0s7ok4uw	5602	58	the	the	DT
cord-001835-0s7ok4uw	5602	59	literature	literature	NN
cord-001835-0s7ok4uw	5602	60	,	,	,
cord-001835-0s7ok4uw	5602	61	and	and	CC
cord-001835-0s7ok4uw	5602	62	the	the	DT
cord-001835-0s7ok4uw	5602	63	substrates	substrate	NNS
cord-001835-0s7ok4uw	5602	64	for	for	IN
cord-001835-0s7ok4uw	5602	65	these	these	DT
cord-001835-0s7ok4uw	5602	66	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5602	67	had	have	VBD
cord-001835-0s7ok4uw	5602	68	been	be	VBN
cord-001835-0s7ok4uw	5602	69	elusive	elusive	JJ
cord-001835-0s7ok4uw	5602	70	.	.	.
cord-001835-0s7ok4uw	5603	1	Both	both	DT
cord-001835-0s7ok4uw	5603	2	PRMT7	PRMT7	NNS
cord-001835-0s7ok4uw	5603	3	and	and	CC
cord-001835-0s7ok4uw	5603	4	PRMT9	PRMT9	NNP
cord-001835-0s7ok4uw	5603	5	are	be	VBP
cord-001835-0s7ok4uw	5603	6	distinct	distinct	JJ
cord-001835-0s7ok4uw	5603	7	members	member	NNS
cord-001835-0s7ok4uw	5603	8	of	of	IN
cord-001835-0s7ok4uw	5603	9	the	the	DT
cord-001835-0s7ok4uw	5603	10	family	family	NN
cord-001835-0s7ok4uw	5603	11	with	with	IN
cord-001835-0s7ok4uw	5603	12	two	two	CD
cord-001835-0s7ok4uw	5603	13	methyltransferase	methyltransferase	NN
cord-001835-0s7ok4uw	5603	14	or	or	CC
cord-001835-0s7ok4uw	5603	15	methyltransferase	methyltransferase	NN
cord-001835-0s7ok4uw	5603	16	-	-	HYPH
cord-001835-0s7ok4uw	5603	17	like	like	JJ
cord-001835-0s7ok4uw	5603	18	domains	domain	NNS
cord-001835-0s7ok4uw	5603	19	and	and	CC
cord-001835-0s7ok4uw	5603	20	containing	contain	VBG
cord-001835-0s7ok4uw	5603	21	acidic	acidic	JJ
cord-001835-0s7ok4uw	5603	22	residues	residue	NNS
cord-001835-0s7ok4uw	5603	23	in	in	IN
cord-001835-0s7ok4uw	5603	24	otherwise	otherwise	RB
cord-001835-0s7ok4uw	5603	25	well	well	RB
cord-001835-0s7ok4uw	5603	26	-	-	HYPH
cord-001835-0s7ok4uw	5603	27	conserved	conserve	VBN
cord-001835-0s7ok4uw	5603	28	substrate	substrate	NN
cord-001835-0s7ok4uw	5603	29	double	double	JJ
cord-001835-0s7ok4uw	5603	30	E	e	NN
cord-001835-0s7ok4uw	5603	31	binding	binding	NN
cord-001835-0s7ok4uw	5603	32	motif	motif	NN
cord-001835-0s7ok4uw	5603	33	,	,	,
cord-001835-0s7ok4uw	5603	34	features	feature	VBZ
cord-001835-0s7ok4uw	5603	35	not	not	RB
cord-001835-0s7ok4uw	5603	36	seen	see	VBN
cord-001835-0s7ok4uw	5603	37	in	in	IN
cord-001835-0s7ok4uw	5603	38	the	the	DT
cord-001835-0s7ok4uw	5603	39	other	other	JJ
cord-001835-0s7ok4uw	5603	40	PRMT	PRMT	NNP
cord-001835-0s7ok4uw	5603	41	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5603	42	.	.	.
cord-001835-0s7ok4uw	5604	1	Recent	recent	JJ
cord-001835-0s7ok4uw	5604	2	work	work	NN
cord-001835-0s7ok4uw	5604	3	in	in	IN
cord-001835-0s7ok4uw	5604	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5604	5	laboratory	laboratory	NN
cord-001835-0s7ok4uw	5604	6	confirmed	confirm	VBD
cord-001835-0s7ok4uw	5604	7	PRMT7	PRMT7	NNP
cord-001835-0s7ok4uw	5604	8	as	as	IN
cord-001835-0s7ok4uw	5604	9	the	the	DT
cord-001835-0s7ok4uw	5604	10	only	only	JJ
cord-001835-0s7ok4uw	5604	11	type	type	NN
cord-001835-0s7ok4uw	5604	12	III	III	NNP
cord-001835-0s7ok4uw	5604	13	MMA	MMA	NNP
cord-001835-0s7ok4uw	5604	14	-	-	HYPH
cord-001835-0s7ok4uw	5604	15	forming	form	VBG
cord-001835-0s7ok4uw	5604	16	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5604	17	in	in	IN
cord-001835-0s7ok4uw	5604	18	the	the	DT
cord-001835-0s7ok4uw	5604	19	group	group	NN
cord-001835-0s7ok4uw	5604	20	,	,	,
cord-001835-0s7ok4uw	5604	21	with	with	IN
cord-001835-0s7ok4uw	5604	22	a	a	DT
cord-001835-0s7ok4uw	5604	23	unusual	unusual	JJ
cord-001835-0s7ok4uw	5604	24	low	low	JJ
cord-001835-0s7ok4uw	5604	25	temperature	temperature	NN
cord-001835-0s7ok4uw	5604	26	optimum	optimum	NN
cord-001835-0s7ok4uw	5604	27	for	for	IN
cord-001835-0s7ok4uw	5604	28	activity	activity	NN
cord-001835-0s7ok4uw	5604	29	,	,	,
cord-001835-0s7ok4uw	5604	30	and	and	CC
cord-001835-0s7ok4uw	5604	31	a	a	DT
cord-001835-0s7ok4uw	5604	32	heretofore	heretofore	RB
cord-001835-0s7ok4uw	5604	33	not	not	RB
cord-001835-0s7ok4uw	5604	34	seen	see	VBN
cord-001835-0s7ok4uw	5604	35	preference	preference	NN
cord-001835-0s7ok4uw	5604	36	for	for	IN
cord-001835-0s7ok4uw	5604	37	a	a	DT
cord-001835-0s7ok4uw	5604	38	basic	basic	JJ
cord-001835-0s7ok4uw	5604	39	stretch	stretch	NN
cord-001835-0s7ok4uw	5604	40	of	of	IN
cord-001835-0s7ok4uw	5604	41	residues	residue	NNS
cord-001835-0s7ok4uw	5604	42	in	in	IN
cord-001835-0s7ok4uw	5604	43	an	an	DT
cord-001835-0s7ok4uw	5604	44	R	r	NN
cord-001835-0s7ok4uw	5604	45	-	-	HYPH
cord-001835-0s7ok4uw	5604	46	X	x	NN
cord-001835-0s7ok4uw	5604	47	-	-	HYPH
cord-001835-0s7ok4uw	5604	48	R	r	NN
cord-001835-0s7ok4uw	5604	49	sequence	sequence	NN
cord-001835-0s7ok4uw	5604	50	for	for	IN
cord-001835-0s7ok4uw	5604	51	methylation	methylation	NN
cord-001835-0s7ok4uw	5604	52	.	.	.
cord-001835-0s7ok4uw	5605	1	Mutations	mutation	NNS
cord-001835-0s7ok4uw	5605	2	of	of	IN
cord-001835-0s7ok4uw	5605	3	the	the	DT
cord-001835-0s7ok4uw	5605	4	acidic	acidic	JJ
cord-001835-0s7ok4uw	5605	5	residues	residue	NNS
cord-001835-0s7ok4uw	5605	6	in	in	IN
cord-001835-0s7ok4uw	5605	7	the	the	DT
cord-001835-0s7ok4uw	5605	8	substrate	substrate	NN
cord-001835-0s7ok4uw	5605	9	-	-	HYPH
cord-001835-0s7ok4uw	5605	10	binding	bind	VBG
cord-001835-0s7ok4uw	5605	11	motif	motif	NN
cord-001835-0s7ok4uw	5605	12	results	result	NNS
cord-001835-0s7ok4uw	5605	13	in	in	IN
cord-001835-0s7ok4uw	5605	14	a	a	DT
cord-001835-0s7ok4uw	5605	15	loss	loss	NN
cord-001835-0s7ok4uw	5605	16	of	of	IN
cord-001835-0s7ok4uw	5605	17	the	the	DT
cord-001835-0s7ok4uw	5605	18	specific	specific	JJ
cord-001835-0s7ok4uw	5605	19	R	r	NN
cord-001835-0s7ok4uw	5605	20	-	-	HYPH
cord-001835-0s7ok4uw	5605	21	X	x	NN
cord-001835-0s7ok4uw	5605	22	-	-	HYPH
cord-001835-0s7ok4uw	5605	23	R	r	NN
cord-001835-0s7ok4uw	5605	24	activity	activity	NN
cord-001835-0s7ok4uw	5605	25	and	and	CC
cord-001835-0s7ok4uw	5605	26	the	the	DT
cord-001835-0s7ok4uw	5605	27	appearance	appearance	NN
cord-001835-0s7ok4uw	5605	28	of	of	IN
cord-001835-0s7ok4uw	5605	29	a	a	DT
cord-001835-0s7ok4uw	5605	30	G	g	NN
cord-001835-0s7ok4uw	5605	31	-	-	HYPH
cord-001835-0s7ok4uw	5605	32	R	r	NN
cord-001835-0s7ok4uw	5605	33	-	-	HYPH
cord-001835-0s7ok4uw	5605	34	G	g	NN
cord-001835-0s7ok4uw	5605	35	specificity	specificity	NN
cord-001835-0s7ok4uw	5605	36	typical	typical	JJ
cord-001835-0s7ok4uw	5605	37	of	of	IN
cord-001835-0s7ok4uw	5605	38	many	many	JJ
cord-001835-0s7ok4uw	5605	39	of	of	IN
cord-001835-0s7ok4uw	5605	40	the	the	DT
cord-001835-0s7ok4uw	5605	41	other	other	JJ
cord-001835-0s7ok4uw	5605	42	PRMTs	prmt	NNS
cord-001835-0s7ok4uw	5605	43	.	.	.
cord-001835-0s7ok4uw	5606	1	The	the	DT
cord-001835-0s7ok4uw	5606	2	physiological	physiological	JJ
cord-001835-0s7ok4uw	5606	3	substrate	substrate	NN
cord-001835-0s7ok4uw	5606	4	of	of	IN
cord-001835-0s7ok4uw	5606	5	PRMT7	prmt7	NN
cord-001835-0s7ok4uw	5606	6	has	have	VBZ
cord-001835-0s7ok4uw	5606	7	yet	yet	RB
cord-001835-0s7ok4uw	5606	8	to	to	TO
cord-001835-0s7ok4uw	5606	9	be	be	VB
cord-001835-0s7ok4uw	5606	10	confirmed	confirm	VBN
cord-001835-0s7ok4uw	5606	11	,	,	,
cord-001835-0s7ok4uw	5606	12	although	although	IN
cord-001835-0s7ok4uw	5606	13	histone	histone	NNP
cord-001835-0s7ok4uw	5606	14	H2B	H2B	NNP
cord-001835-0s7ok4uw	5606	15	is	be	VBZ
cord-001835-0s7ok4uw	5606	16	an	an	DT
cord-001835-0s7ok4uw	5606	17	effective	effective	JJ
cord-001835-0s7ok4uw	5606	18	in	in	IN
cord-001835-0s7ok4uw	5606	19	vitro	vitro	FW
cord-001835-0s7ok4uw	5606	20	substrate	substrate	NN
cord-001835-0s7ok4uw	5606	21	.	.	.
cord-001835-0s7ok4uw	5607	1	PRMT9	PRMT9	NNP
cord-001835-0s7ok4uw	5607	2	,	,	,
cord-001835-0s7ok4uw	5607	3	on	on	IN
cord-001835-0s7ok4uw	5607	4	the	the	DT
cord-001835-0s7ok4uw	5607	5	other	other	JJ
cord-001835-0s7ok4uw	5607	6	hand	hand	NN
cord-001835-0s7ok4uw	5607	7	,	,	,
cord-001835-0s7ok4uw	5607	8	had	have	VBD
cord-001835-0s7ok4uw	5607	9	no	no	DT
cord-001835-0s7ok4uw	5607	10	reported	report	VBN
cord-001835-0s7ok4uw	5607	11	activity	activity	NN
cord-001835-0s7ok4uw	5607	12	,	,	,
cord-001835-0s7ok4uw	5607	13	until	until	IN
cord-001835-0s7ok4uw	5607	14	immunoprecipitation	immunoprecipitation	NN
cord-001835-0s7ok4uw	5607	15	from	from	IN
cord-001835-0s7ok4uw	5607	16	HeLa	HeLa	NNP
cord-001835-0s7ok4uw	5607	17	cells	cell	NNS
cord-001835-0s7ok4uw	5607	18	showed	show	VBD
cord-001835-0s7ok4uw	5607	19	it	-PRON-	PRP
cord-001835-0s7ok4uw	5607	20	pulled	pull	VBD
cord-001835-0s7ok4uw	5607	21	down	down	RP
cord-001835-0s7ok4uw	5607	22	two	two	CD
cord-001835-0s7ok4uw	5607	23	splicing	splicing	NN
cord-001835-0s7ok4uw	5607	24	factors	factor	NNS
cord-001835-0s7ok4uw	5607	25	,	,	,
cord-001835-0s7ok4uw	5607	26	SF3B2	SF3B2	NNP
cord-001835-0s7ok4uw	5607	27	and	and	CC
cord-001835-0s7ok4uw	5607	28	SF3B4	SF3B4	NNP
cord-001835-0s7ok4uw	5607	29	,	,	,
cord-001835-0s7ok4uw	5607	30	in	in	IN
cord-001835-0s7ok4uw	5607	31	a	a	DT
cord-001835-0s7ok4uw	5607	32	complex	complex	NN
cord-001835-0s7ok4uw	5607	33	.	.	.
cord-001835-0s7ok4uw	5608	1	Amino	amino	NN
cord-001835-0s7ok4uw	5608	2	acid	acid	NN
cord-001835-0s7ok4uw	5608	3	analysis	analysis	NN
cord-001835-0s7ok4uw	5608	4	showed	show	VBD
cord-001835-0s7ok4uw	5608	5	that	that	IN
cord-001835-0s7ok4uw	5608	6	PRMT9	PRMT9	NNP
cord-001835-0s7ok4uw	5608	7	methylates	methylates	NNP
cord-001835-0s7ok4uw	5608	8	SF3B2	SF3B2	NNP
cord-001835-0s7ok4uw	5608	9	to	to	TO
cord-001835-0s7ok4uw	5608	10	produce	produce	VB
cord-001835-0s7ok4uw	5608	11	both	both	DT
cord-001835-0s7ok4uw	5608	12	MMA	MMA	NNP
cord-001835-0s7ok4uw	5608	13	and	and	CC
cord-001835-0s7ok4uw	5608	14	SDMA	SDMA	NNP
cord-001835-0s7ok4uw	5608	15	,	,	,
cord-001835-0s7ok4uw	5608	16	thus	thus	RB
cord-001835-0s7ok4uw	5608	17	making	make	VBG
cord-001835-0s7ok4uw	5608	18	it	-PRON-	PRP
cord-001835-0s7ok4uw	5608	19	the	the	DT
cord-001835-0s7ok4uw	5608	20	second	second	JJ
cord-001835-0s7ok4uw	5608	21	type	type	NN
cord-001835-0s7ok4uw	5608	22	II	II	NNP
cord-001835-0s7ok4uw	5608	23	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5608	24	in	in	IN
cord-001835-0s7ok4uw	5608	25	mammals	mammal	NNS
cord-001835-0s7ok4uw	5608	26	.	.	.
cord-001835-0s7ok4uw	5609	1	PRMT9	PRMT9	NNP
cord-001835-0s7ok4uw	5610	1	knockdown	knockdown	NN
cord-001835-0s7ok4uw	5610	2	results	result	NNS
cord-001835-0s7ok4uw	5610	3	in	in	IN
cord-001835-0s7ok4uw	5610	4	modulation	modulation	NN
cord-001835-0s7ok4uw	5610	5	of	of	IN
cord-001835-0s7ok4uw	5610	6	alternative	alternative	JJ
cord-001835-0s7ok4uw	5610	7	splicing	splicing	NN
cord-001835-0s7ok4uw	5610	8	events	event	NNS
cord-001835-0s7ok4uw	5610	9	.	.	.
cord-001835-0s7ok4uw	5611	1	This	this	DT
cord-001835-0s7ok4uw	5611	2	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5611	3	appears	appear	VBZ
cord-001835-0s7ok4uw	5611	4	to	to	TO
cord-001835-0s7ok4uw	5611	5	be	be	VB
cord-001835-0s7ok4uw	5611	6	relatively	relatively	RB
cord-001835-0s7ok4uw	5611	7	specific	specific	JJ
cord-001835-0s7ok4uw	5611	8	for	for	IN
cord-001835-0s7ok4uw	5611	9	the	the	DT
cord-001835-0s7ok4uw	5611	10	SF3B2	SF3B2	NNP
cord-001835-0s7ok4uw	5611	11	protein	protein	NN
cord-001835-0s7ok4uw	5611	12	;	;	:
cord-001835-0s7ok4uw	5611	13	a	a	DT
cord-001835-0s7ok4uw	5611	14	peptide	peptide	NN
cord-001835-0s7ok4uw	5611	15	containing	contain	VBG
cord-001835-0s7ok4uw	5611	16	the	the	DT
cord-001835-0s7ok4uw	5611	17	methylatable	methylatable	NNP
cord-001835-0s7ok4uw	5611	18	arginine	arginine	NN
cord-001835-0s7ok4uw	5611	19	residue	residue	NN
cord-001835-0s7ok4uw	5611	20	was	be	VBD
cord-001835-0s7ok4uw	5611	21	not	not	RB
cord-001835-0s7ok4uw	5611	22	found	find	VBN
cord-001835-0s7ok4uw	5611	23	to	to	TO
cord-001835-0s7ok4uw	5611	24	be	be	VB
cord-001835-0s7ok4uw	5611	25	a	a	DT
cord-001835-0s7ok4uw	5611	26	substrate	substrate	NN
cord-001835-0s7ok4uw	5611	27	,	,	,
cord-001835-0s7ok4uw	5611	28	and	and	CC
cord-001835-0s7ok4uw	5611	29	typical	typical	JJ
cord-001835-0s7ok4uw	5611	30	substrates	substrate	NNS
cord-001835-0s7ok4uw	5611	31	of	of	IN
cord-001835-0s7ok4uw	5611	32	other	other	JJ
cord-001835-0s7ok4uw	5611	33	PRMTs	prmt	NNS
cord-001835-0s7ok4uw	5611	34	are	be	VBP
cord-001835-0s7ok4uw	5611	35	not	not	RB
cord-001835-0s7ok4uw	5611	36	recognized	recognize	VBN
cord-001835-0s7ok4uw	5611	37	by	by	IN
cord-001835-0s7ok4uw	5611	38	PRMT9	PRMT9	NNP
cord-001835-0s7ok4uw	5611	39	.	.	.
cord-001835-0s7ok4uw	5612	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5612	2	found	find	VBD
cord-001835-0s7ok4uw	5612	3	that	that	IN
cord-001835-0s7ok4uw	5612	4	the	the	DT
cord-001835-0s7ok4uw	5612	5	position	position	NN
cord-001835-0s7ok4uw	5612	6	of	of	IN
cord-001835-0s7ok4uw	5612	7	the	the	DT
cord-001835-0s7ok4uw	5612	8	methylated	methylate	VBN
cord-001835-0s7ok4uw	5612	9	arginine	arginine	NN
cord-001835-0s7ok4uw	5612	10	residue	residue	NN
cord-001835-0s7ok4uw	5612	11	in	in	IN
cord-001835-0s7ok4uw	5612	12	SF3B2	SF3B2	NNP
cord-001835-0s7ok4uw	5612	13	is	be	VBZ
cord-001835-0s7ok4uw	5612	14	important	important	JJ
cord-001835-0s7ok4uw	5612	15	,	,	,
cord-001835-0s7ok4uw	5612	16	and	and	CC
cord-001835-0s7ok4uw	5612	17	the	the	DT
cord-001835-0s7ok4uw	5612	18	acidic	acidic	JJ
cord-001835-0s7ok4uw	5612	19	residues	residue	NNS
cord-001835-0s7ok4uw	5612	20	in	in	IN
cord-001835-0s7ok4uw	5612	21	the	the	DT
cord-001835-0s7ok4uw	5612	22	substrate	substrate	NN
cord-001835-0s7ok4uw	5612	23	-	-	HYPH
cord-001835-0s7ok4uw	5612	24	binding	bind	VBG
cord-001835-0s7ok4uw	5612	25	motif	motif	NN
cord-001835-0s7ok4uw	5612	26	also	also	RB
cord-001835-0s7ok4uw	5612	27	play	play	VBP
cord-001835-0s7ok4uw	5612	28	an	an	DT
cord-001835-0s7ok4uw	5612	29	important	important	JJ
cord-001835-0s7ok4uw	5612	30	role	role	NN
cord-001835-0s7ok4uw	5612	31	in	in	IN
cord-001835-0s7ok4uw	5612	32	substrate	substrate	NN
cord-001835-0s7ok4uw	5612	33	recognition	recognition	NN
cord-001835-0s7ok4uw	5612	34	.	.	.
cord-001835-0s7ok4uw	5613	1	Thus	thus	RB
cord-001835-0s7ok4uw	5613	2	,	,	,
cord-001835-0s7ok4uw	5613	3	PRMT7	PRMT7	NNP
cord-001835-0s7ok4uw	5613	4	and	and	CC
cord-001835-0s7ok4uw	5613	5	PRMT9	PRMT9	NNP
cord-001835-0s7ok4uw	5613	6	represent	represent	VBP
cord-001835-0s7ok4uw	5613	7	unique	unique	JJ
cord-001835-0s7ok4uw	5613	8	members	member	NNS
cord-001835-0s7ok4uw	5613	9	of	of	IN
cord-001835-0s7ok4uw	5613	10	the	the	DT
cord-001835-0s7ok4uw	5613	11	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	5613	12	PRMT	PRMT	NNP
cord-001835-0s7ok4uw	5613	13	family	family	NN
cord-001835-0s7ok4uw	5613	14	.	.	.
cord-001835-0s7ok4uw	5614	1	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	5614	2	peroxide	peroxide	NN
cord-001835-0s7ok4uw	5614	3	levels	level	NNS
cord-001835-0s7ok4uw	5614	4	,	,	,
cord-001835-0s7ok4uw	5614	5	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	5614	6	hormones	hormone	NNS
cord-001835-0s7ok4uw	5614	7	(	(	-LRB-
cord-001835-0s7ok4uw	5614	8	cytokinins	cytokinins	NNP
cord-001835-0s7ok4uw	5614	9	,	,	,
cord-001835-0s7ok4uw	5614	10	salycilic	salycilic	NNP
cord-001835-0s7ok4uw	5614	11	acid	acid	NN
cord-001835-0s7ok4uw	5614	12	,	,	,
cord-001835-0s7ok4uw	5614	13	as	as	RB
cord-001835-0s7ok4uw	5614	14	well	well	RB
cord-001835-0s7ok4uw	5614	15	as	as	IN
cord-001835-0s7ok4uw	5614	16	jasmonic	jasmonic	NNP
cord-001835-0s7ok4uw	5614	17	acid	acid	NN
cord-001835-0s7ok4uw	5614	18	and	and	CC
cord-001835-0s7ok4uw	5614	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5614	20	conjugates	conjugate	NNS
cord-001835-0s7ok4uw	5614	21	)	)	-RRB-
cord-001835-0s7ok4uw	5614	22	,	,	,
cord-001835-0s7ok4uw	5614	23	polyphenolics	polyphenolic	NNS
cord-001835-0s7ok4uw	5614	24	and	and	CC
cord-001835-0s7ok4uw	5614	25	terpenoids	terpenoid	NNS
cord-001835-0s7ok4uw	5614	26	in	in	IN
cord-001835-0s7ok4uw	5614	27	a	a	DT
cord-001835-0s7ok4uw	5614	28	model	model	NN
cord-001835-0s7ok4uw	5614	29	system	system	NN
cord-001835-0s7ok4uw	5614	30	of	of	IN
cord-001835-0s7ok4uw	5614	31	A.	a.	NN
cord-001835-0s7ok4uw	5614	32	alba	alba	NNP
cord-001835-0s7ok4uw	5614	33	in	in	IN
cord-001835-0s7ok4uw	5614	34	vitro	vitro	FW
cord-001835-0s7ok4uw	5614	35	with	with	IN
cord-001835-0s7ok4uw	5614	36	inhibition	inhibition	NN
cord-001835-0s7ok4uw	5614	37	of	of	IN
cord-001835-0s7ok4uw	5614	38	rootng	rootng	NN
cord-001835-0s7ok4uw	5614	39	and	and	CC
cord-001835-0s7ok4uw	5614	40	stimulation	stimulation	NN
cord-001835-0s7ok4uw	5614	41	of	of	IN
cord-001835-0s7ok4uw	5614	42	callusogenesis	callusogenesis	NNP
cord-001835-0s7ok4uw	5614	43	by	by	IN
cord-001835-0s7ok4uw	5614	44	means	mean	NNS
cord-001835-0s7ok4uw	5614	45	of	of	IN
cord-001835-0s7ok4uw	5614	46	individual	individual	JJ
cord-001835-0s7ok4uw	5614	47	and	and	CC
cord-001835-0s7ok4uw	5614	48	combined	combined	JJ
cord-001835-0s7ok4uw	5614	49	cytokinin	cytokinin	NNS
cord-001835-0s7ok4uw	5614	50	and	and	CC
cord-001835-0s7ok4uw	5614	51	cytokinin/	cytokinin/	CD
cord-001835-0s7ok4uw	5614	52	auxin	auxin	NN
cord-001835-0s7ok4uw	5614	53	treatments	treatment	NNS
cord-001835-0s7ok4uw	5614	54	.	.	.
cord-001835-0s7ok4uw	5615	1	Results	result	NNS
cord-001835-0s7ok4uw	5615	2	:	:	:
cord-001835-0s7ok4uw	5615	3	It	-PRON-	PRP
cord-001835-0s7ok4uw	5615	4	was	be	VBD
cord-001835-0s7ok4uw	5615	5	established	establish	VBN
cord-001835-0s7ok4uw	5615	6	that	that	DT
cord-001835-0s7ok4uw	5615	7	inhibition	inhibition	NN
cord-001835-0s7ok4uw	5615	8	of	of	IN
cord-001835-0s7ok4uw	5615	9	rooting	rooting	NN
cord-001835-0s7ok4uw	5615	10	and	and	CC
cord-001835-0s7ok4uw	5615	11	stimulation	stimulation	NN
cord-001835-0s7ok4uw	5615	12	of	of	IN
cord-001835-0s7ok4uw	5615	13	callusogenesis	callusogenesis	NN
cord-001835-0s7ok4uw	5615	14	caused	cause	VBN
cord-001835-0s7ok4uw	5615	15	by	by	IN
cord-001835-0s7ok4uw	5615	16	benzyl	benzyl	NN
cord-001835-0s7ok4uw	5615	17	adenine	adenine	NN
cord-001835-0s7ok4uw	5615	18	(	(	-LRB-
cord-001835-0s7ok4uw	5615	19	BA	BA	NNP
cord-001835-0s7ok4uw	5615	20	)	)	-RRB-
cord-001835-0s7ok4uw	5615	21	or	or	CC
cord-001835-0s7ok4uw	5615	22	combinations	combination	NNS
cord-001835-0s7ok4uw	5615	23	of	of	IN
cord-001835-0s7ok4uw	5615	24	BA	BA	NNP
cord-001835-0s7ok4uw	5615	25	and	and	CC
cord-001835-0s7ok4uw	5615	26	indole-3-butiric	indole-3-butiric	NNP
cord-001835-0s7ok4uw	5615	27	acid	acid	NN
cord-001835-0s7ok4uw	5615	28	(	(	-LRB-
cord-001835-0s7ok4uw	5615	29	IBA	IBA	NNP
cord-001835-0s7ok4uw	5615	30	)	)	-RRB-
cord-001835-0s7ok4uw	5616	1	in	in	IN
cord-001835-0s7ok4uw	5616	2	vitro	vitro	FW
cord-001835-0s7ok4uw	5616	3	were	be	VBD
cord-001835-0s7ok4uw	5616	4	related	relate	VBN
cord-001835-0s7ok4uw	5616	5	to	to	IN
cord-001835-0s7ok4uw	5616	6	elevation	elevation	NN
cord-001835-0s7ok4uw	5616	7	of	of	IN
cord-001835-0s7ok4uw	5616	8	sesquiterpenoids	sesquiterpenoid	NNS
cord-001835-0s7ok4uw	5616	9	in	in	IN
cord-001835-0s7ok4uw	5616	10	the	the	DT
cord-001835-0s7ok4uw	5616	11	essential	essential	JJ
cord-001835-0s7ok4uw	5616	12	oils	oil	NNS
cord-001835-0s7ok4uw	5616	13	,	,	,
cord-001835-0s7ok4uw	5616	14	as	as	RB
cord-001835-0s7ok4uw	5616	15	well	well	RB
cord-001835-0s7ok4uw	5616	16	as	as	IN
cord-001835-0s7ok4uw	5616	17	polyphenolics	polyphenolic	NNS
cord-001835-0s7ok4uw	5616	18	content	content	NN
cord-001835-0s7ok4uw	5616	19	,	,	,
cord-001835-0s7ok4uw	5616	20	accompanied	accompany	VBN
cord-001835-0s7ok4uw	5616	21	by	by	IN
cord-001835-0s7ok4uw	5616	22	a	a	DT
cord-001835-0s7ok4uw	5616	23	drop	drop	NN
cord-001835-0s7ok4uw	5616	24	of	of	IN
cord-001835-0s7ok4uw	5616	25	stress	stress	NN
cord-001835-0s7ok4uw	5616	26	hormones	hormone	NNS
cord-001835-0s7ok4uw	5616	27	,	,	,
cord-001835-0s7ok4uw	5616	28	bioactive	bioactive	JJ
cord-001835-0s7ok4uw	5616	29	cytokinins	cytokinin	NNS
cord-001835-0s7ok4uw	5616	30	and	and	CC
cord-001835-0s7ok4uw	5616	31	preservation	preservation	NN
cord-001835-0s7ok4uw	5616	32	of	of	IN
cord-001835-0s7ok4uw	5616	33	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	5616	34	stress	stress	NN
cord-001835-0s7ok4uw	5616	35	and	and	CC
cord-001835-0s7ok4uw	5616	36	lipid	lipid	NN
cord-001835-0s7ok4uw	5616	37	peroxidation	peroxidation	NN
cord-001835-0s7ok4uw	5616	38	levels	level	NNS
cord-001835-0s7ok4uw	5616	39	,	,	,
cord-001835-0s7ok4uw	5616	40	as	as	IN
cord-001835-0s7ok4uw	5616	41	compared	compare	VBN
cord-001835-0s7ok4uw	5616	42	with	with	IN
cord-001835-0s7ok4uw	5616	43	non	non	JJ
cord-001835-0s7ok4uw	5616	44	-	-	JJ
cord-001835-0s7ok4uw	5616	45	treated	treated	JJ
cord-001835-0s7ok4uw	5616	46	control	control	NN
cord-001835-0s7ok4uw	5616	47	.	.	.
cord-001835-0s7ok4uw	5617	1	Individual	individual	JJ
cord-001835-0s7ok4uw	5617	2	treatments	treatment	NNS
cord-001835-0s7ok4uw	5617	3	with	with	IN
cord-001835-0s7ok4uw	5617	4	either	either	CC
cord-001835-0s7ok4uw	5617	5	IBA	IBA	NNP
cord-001835-0s7ok4uw	5617	6	or	or	CC
cord-001835-0s7ok4uw	5617	7	BA	BA	NNP
cord-001835-0s7ok4uw	5617	8	,	,	,
cord-001835-0s7ok4uw	5617	9	also	also	RB
cord-001835-0s7ok4uw	5617	10	increased	increase	VBD
cord-001835-0s7ok4uw	5617	11	the	the	DT
cord-001835-0s7ok4uw	5617	12	sesquiterpenoid	sesquiterpenoid	NNP
cord-001835-0s7ok4uw	5617	13	content	content	NN
cord-001835-0s7ok4uw	5617	14	in	in	IN
cord-001835-0s7ok4uw	5617	15	the	the	DT
cord-001835-0s7ok4uw	5617	16	essential	essential	JJ
cord-001835-0s7ok4uw	5617	17	oil	oil	NN
cord-001835-0s7ok4uw	5617	18	of	of	IN
cord-001835-0s7ok4uw	5617	19	the	the	DT
cord-001835-0s7ok4uw	5617	20	plant	plant	NN
cord-001835-0s7ok4uw	5617	21	,	,	,
cord-001835-0s7ok4uw	5617	22	in	in	IN
cord-001835-0s7ok4uw	5617	23	a	a	DT
cord-001835-0s7ok4uw	5617	24	concentration	concentration	NN
cord-001835-0s7ok4uw	5617	25	related	relate	VBN
cord-001835-0s7ok4uw	5617	26	manner	manner	NN
cord-001835-0s7ok4uw	5617	27	,	,	,
cord-001835-0s7ok4uw	5617	28	this	this	DT
cord-001835-0s7ok4uw	5617	29	effect	effect	NN
cord-001835-0s7ok4uw	5617	30	being	be	VBG
cord-001835-0s7ok4uw	5617	31	more	more	RBR
cord-001835-0s7ok4uw	5617	32	profound	profound	JJ
cord-001835-0s7ok4uw	5617	33	after	after	IN
cord-001835-0s7ok4uw	5617	34	BA	BA	NNP
cord-001835-0s7ok4uw	5617	35	treatment	treatment	NN
cord-001835-0s7ok4uw	5617	36	.	.	.
cord-001835-0s7ok4uw	5618	1	In	in	IN
cord-001835-0s7ok4uw	5618	2	addition	addition	NN
cord-001835-0s7ok4uw	5618	3	,	,	,
cord-001835-0s7ok4uw	5618	4	BA	BA	NNP
cord-001835-0s7ok4uw	5618	5	treated	treat	VBD
cord-001835-0s7ok4uw	5618	6	plants	plant	NNS
cord-001835-0s7ok4uw	5618	7	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	5618	8	a	a	DT
cord-001835-0s7ok4uw	5618	9	drop	drop	NN
cord-001835-0s7ok4uw	5618	10	of	of	IN
cord-001835-0s7ok4uw	5618	11	protein	protein	NN
cord-001835-0s7ok4uw	5618	12	levels	level	NNS
cord-001835-0s7ok4uw	5618	13	of	of	IN
cord-001835-0s7ok4uw	5618	14	the	the	DT
cord-001835-0s7ok4uw	5618	15	aerial	aerial	JJ
cord-001835-0s7ok4uw	5618	16	samples	sample	NNS
cord-001835-0s7ok4uw	5618	17	,	,	,
cord-001835-0s7ok4uw	5618	18	as	as	RB
cord-001835-0s7ok4uw	5618	19	well	well	RB
cord-001835-0s7ok4uw	5618	20	as	as	IN
cord-001835-0s7ok4uw	5618	21	profound	profound	JJ
cord-001835-0s7ok4uw	5618	22	differences	difference	NNS
cord-001835-0s7ok4uw	5618	23	of	of	IN
cord-001835-0s7ok4uw	5618	24	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5618	25	activity	activity	NN
cord-001835-0s7ok4uw	5618	26	in	in	IN
cord-001835-0s7ok4uw	5618	27	the	the	DT
cord-001835-0s7ok4uw	5618	28	callus	callus	NN
cord-001835-0s7ok4uw	5618	29	tissues	tissue	NNS
cord-001835-0s7ok4uw	5618	30	,	,	,
cord-001835-0s7ok4uw	5618	31	as	as	IN
cord-001835-0s7ok4uw	5618	32	compared	compare	VBN
cord-001835-0s7ok4uw	5618	33	with	with	IN
cord-001835-0s7ok4uw	5618	34	callus	callus	NN
cord-001835-0s7ok4uw	5618	35	of	of	IN
cord-001835-0s7ok4uw	5618	36	plants	plant	NNS
cord-001835-0s7ok4uw	5618	37	treated	treat	VBN
cord-001835-0s7ok4uw	5618	38	with	with	IN
cord-001835-0s7ok4uw	5618	39	different	different	JJ
cord-001835-0s7ok4uw	5618	40	combinations	combination	NNS
cord-001835-0s7ok4uw	5618	41	of	of	IN
cord-001835-0s7ok4uw	5618	42	BA	BA	NNP
cord-001835-0s7ok4uw	5618	43	and	and	CC
cord-001835-0s7ok4uw	5618	44	IBA	IBA	NNP
cord-001835-0s7ok4uw	5618	45	.	.	.
cord-001835-0s7ok4uw	5619	1	Conclusion	conclusion	NN
cord-001835-0s7ok4uw	5619	2	:	:	:
cord-001835-0s7ok4uw	5620	1	The	the	DT
cord-001835-0s7ok4uw	5620	2	results	result	NNS
cord-001835-0s7ok4uw	5620	3	of	of	IN
cord-001835-0s7ok4uw	5620	4	the	the	DT
cord-001835-0s7ok4uw	5620	5	present	present	JJ
cord-001835-0s7ok4uw	5620	6	work	work	NN
cord-001835-0s7ok4uw	5620	7	indicate	indicate	VBP
cord-001835-0s7ok4uw	5620	8	that	that	IN
cord-001835-0s7ok4uw	5620	9	alterations	alteration	NNS
cord-001835-0s7ok4uw	5620	10	of	of	IN
cord-001835-0s7ok4uw	5620	11	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	5620	12	phytohormonal	phytohormonal	JJ
cord-001835-0s7ok4uw	5620	13	levels	level	NNS
cord-001835-0s7ok4uw	5620	14	,	,	,
cord-001835-0s7ok4uw	5620	15	caused	cause	VBN
cord-001835-0s7ok4uw	5620	16	by	by	IN
cord-001835-0s7ok4uw	5620	17	exogenous	exogenous	JJ
cord-001835-0s7ok4uw	5620	18	plant	plant	NN
cord-001835-0s7ok4uw	5620	19	growth	growth	NN
cord-001835-0s7ok4uw	5620	20	regulators	regulator	NNS
cord-001835-0s7ok4uw	5620	21	treatment	treatment	NN
cord-001835-0s7ok4uw	5620	22	,	,	,
cord-001835-0s7ok4uw	5620	23	might	may	MD
cord-001835-0s7ok4uw	5620	24	be	be	VB
cord-001835-0s7ok4uw	5620	25	the	the	DT
cord-001835-0s7ok4uw	5620	26	mediator	mediator	NN
cord-001835-0s7ok4uw	5620	27	between	between	IN
cord-001835-0s7ok4uw	5620	28	primary	primary	JJ
cord-001835-0s7ok4uw	5620	29	and	and	CC
cord-001835-0s7ok4uw	5620	30	secondary	secondary	JJ
cord-001835-0s7ok4uw	5620	31	metabolism	metabolism	NN
cord-001835-0s7ok4uw	5620	32	by	by	IN
cord-001835-0s7ok4uw	5620	33	means	mean	NNS
cord-001835-0s7ok4uw	5620	34	of	of	IN
cord-001835-0s7ok4uw	5620	35	affecting	affect	VBG
cord-001835-0s7ok4uw	5620	36	protein	protein	NN
cord-001835-0s7ok4uw	5620	37	levels	level	NNS
cord-001835-0s7ok4uw	5620	38	and	and	CC
cord-001835-0s7ok4uw	5620	39	activity	activity	NN
cord-001835-0s7ok4uw	5620	40	of	of	IN
cord-001835-0s7ok4uw	5620	41	key	key	JJ
cord-001835-0s7ok4uw	5620	42	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5620	43	in	in	IN
cord-001835-0s7ok4uw	5620	44	vitro	vitro	FW
cord-001835-0s7ok4uw	5620	45	.	.	.
cord-001835-0s7ok4uw	5621	1	three	three	CD
cord-001835-0s7ok4uw	5621	2	different	different	JJ
cord-001835-0s7ok4uw	5621	3	additives	additive	NNS
cord-001835-0s7ok4uw	5621	4	(	(	-LRB-
cord-001835-0s7ok4uw	5621	5	(	(	-LRB-
cord-001835-0s7ok4uw	5621	6	0.1	0.1	CD
cord-001835-0s7ok4uw	5621	7	%	%	NN
cord-001835-0s7ok4uw	5621	8	(	(	-LRB-
cord-001835-0s7ok4uw	5621	9	v	v	NN
cord-001835-0s7ok4uw	5621	10	/	/	SYM
cord-001835-0s7ok4uw	5621	11	v	v	NN
cord-001835-0s7ok4uw	5621	12	)	)	-RRB-
cord-001835-0s7ok4uw	5621	13	;	;	,
cord-001835-0s7ok4uw	5621	14	formic	formic	JJ
cord-001835-0s7ok4uw	5621	15	acid	acid	NN
cord-001835-0s7ok4uw	5621	16	,	,	,
cord-001835-0s7ok4uw	5621	17	acetic	acetic	JJ
cord-001835-0s7ok4uw	5621	18	acid	acid	NN
cord-001835-0s7ok4uw	5621	19	,	,	,
cord-001835-0s7ok4uw	5621	20	ammonium	ammonium	NN
cord-001835-0s7ok4uw	5621	21	format	format	NN
cord-001835-0s7ok4uw	5621	22	with	with	IN
cord-001835-0s7ok4uw	5621	23	formic	formic	JJ
cord-001835-0s7ok4uw	5621	24	acid	acid	NN
cord-001835-0s7ok4uw	5621	25	)	)	-RRB-
cord-001835-0s7ok4uw	5621	26	have	have	VBP
cord-001835-0s7ok4uw	5621	27	been	be	VBN
cord-001835-0s7ok4uw	5621	28	investigated	investigate	VBN
cord-001835-0s7ok4uw	5621	29	in	in	IN
cord-001835-0s7ok4uw	5621	30	response	response	NN
cord-001835-0s7ok4uw	5621	31	to	to	IN
cord-001835-0s7ok4uw	5621	32	ion	ion	NN
cord-001835-0s7ok4uw	5621	33	intensity	intensity	NN
cord-001835-0s7ok4uw	5621	34	of	of	IN
cord-001835-0s7ok4uw	5621	35	ESI	ESI	NNP
cord-001835-0s7ok4uw	5621	36	-	-	HYPH
cord-001835-0s7ok4uw	5621	37	MS	MS	NNP
cord-001835-0s7ok4uw	5621	38	for	for	IN
cord-001835-0s7ok4uw	5621	39	individual	individual	JJ
cord-001835-0s7ok4uw	5621	40	HNP	HNP	NNP
cord-001835-0s7ok4uw	5621	41	1	1	CD
cord-001835-0s7ok4uw	5621	42	-	-	SYM
cord-001835-0s7ok4uw	5621	43	4	4	CD
cord-001835-0s7ok4uw	5621	44	in	in	IN
cord-001835-0s7ok4uw	5621	45	saliva	saliva	NN
cord-001835-0s7ok4uw	5621	46	.	.	.
cord-001835-0s7ok4uw	5622	1	Kinetex	Kinetex	NNP
cord-001835-0s7ok4uw	5622	2	V	V	NNP
cord-001835-0s7ok4uw	5622	3	R	r	NN
cord-001835-0s7ok4uw	5622	4	column	column	NN
cord-001835-0s7ok4uw	5622	5	separation	separation	NN
cord-001835-0s7ok4uw	5622	6	efficiency	efficiency	NN
cord-001835-0s7ok4uw	5622	7	was	be	VBD
cord-001835-0s7ok4uw	5622	8	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	5622	9	using	use	VBG
cord-001835-0s7ok4uw	5622	10	two	two	CD
cord-001835-0s7ok4uw	5622	11	different	different	JJ
cord-001835-0s7ok4uw	5622	12	column	column	NN
cord-001835-0s7ok4uw	5622	13	dimensions	dimension	NNS
cord-001835-0s7ok4uw	5622	14	(	(	-LRB-
cord-001835-0s7ok4uw	5622	15	50	50	CD
cord-001835-0s7ok4uw	5622	16	x	x	SYM
cord-001835-0s7ok4uw	5622	17	2.1	2.1	CD
cord-001835-0s7ok4uw	5622	18	mm	mm	NNS
cord-001835-0s7ok4uw	5622	19	and	and	CC
cord-001835-0s7ok4uw	5622	20	50	50	CD
cord-001835-0s7ok4uw	5622	21	x	x	SYM
cord-001835-0s7ok4uw	5622	22	3	3	CD
cord-001835-0s7ok4uw	5622	23	mm	mm	NN
cord-001835-0s7ok4uw	5622	24	.	.	.
cord-001835-0s7ok4uw	5622	25	)	)	-RRB-
cord-001835-0s7ok4uw	5623	1	and	and	CC
cord-001835-0s7ok4uw	5623	2	two	two	CD
cord-001835-0s7ok4uw	5623	3	different	different	JJ
cord-001835-0s7ok4uw	5623	4	stationary	stationary	JJ
cord-001835-0s7ok4uw	5623	5	phases	phase	NNS
cord-001835-0s7ok4uw	5623	6	(	(	-LRB-
cord-001835-0s7ok4uw	5623	7	C18	C18	NNP
cord-001835-0s7ok4uw	5623	8	and	and	CC
cord-001835-0s7ok4uw	5623	9	C8	C8	NNP
cord-001835-0s7ok4uw	5623	10	)	)	-RRB-
cord-001835-0s7ok4uw	5623	11	.	.	.
cord-001835-0s7ok4uw	5624	1	Kinetex	Kinetex	NNP
cord-001835-0s7ok4uw	5624	2	V	V	NNP
cord-001835-0s7ok4uw	5624	3	R	r	NN
cord-001835-0s7ok4uw	5624	4	column	column	NN
cord-001835-0s7ok4uw	5624	5	(	(	-LRB-
cord-001835-0s7ok4uw	5624	6	homogenous	homogenous	JJ
cord-001835-0s7ok4uw	5624	7	porous	porous	JJ
cord-001835-0s7ok4uw	5624	8	shell	shell	NN
cord-001835-0s7ok4uw	5624	9	)	)	-RRB-
cord-001835-0s7ok4uw	5624	10	performance	performance	NN
cord-001835-0s7ok4uw	5624	11	was	be	VBD
cord-001835-0s7ok4uw	5624	12	also	also	RB
cord-001835-0s7ok4uw	5624	13	compared	compare	VBN
cord-001835-0s7ok4uw	5624	14	to	to	IN
cord-001835-0s7ok4uw	5624	15	new	new	JJ
cord-001835-0s7ok4uw	5624	16	ultra	ultra	JJ
cord-001835-0s7ok4uw	5624	17	ACE	ace	NN
cord-001835-0s7ok4uw	5624	18	V	v	NN
cord-001835-0s7ok4uw	5624	19	R	r	NN
cord-001835-0s7ok4uw	5624	20	(	(	-LRB-
cord-001835-0s7ok4uw	5624	21	encapsulated	encapsulate	VBN
cord-001835-0s7ok4uw	5624	22	bonded	bond	VBN
cord-001835-0s7ok4uw	5624	23	phase	phase	NN
cord-001835-0s7ok4uw	5624	24	)	)	-RRB-
cord-001835-0s7ok4uw	5624	25	column	column	NN
cord-001835-0s7ok4uw	5624	26	.	.	.
cord-001835-0s7ok4uw	5625	1	Sample	sample	NN
cord-001835-0s7ok4uw	5625	2	optimisation	optimisation	NN
cord-001835-0s7ok4uw	5625	3	revealed	reveal	VBD
cord-001835-0s7ok4uw	5625	4	that	that	IN
cord-001835-0s7ok4uw	5625	5	the	the	DT
cord-001835-0s7ok4uw	5625	6	SPE	SPE	NNP
cord-001835-0s7ok4uw	5625	7	method	method	NN
cord-001835-0s7ok4uw	5625	8	removes	remove	VBZ
cord-001835-0s7ok4uw	5625	9	interference	interference	NN
cord-001835-0s7ok4uw	5625	10	from	from	IN
cord-001835-0s7ok4uw	5625	11	salivary	salivary	JJ
cord-001835-0s7ok4uw	5625	12	glycoproteins	glycoprotein	NNS
cord-001835-0s7ok4uw	5625	13	and	and	CC
cord-001835-0s7ok4uw	5625	14	consequently	consequently	RB
cord-001835-0s7ok4uw	5625	15	yields	yield	VBZ
cord-001835-0s7ok4uw	5625	16	larger	large	JJR
cord-001835-0s7ok4uw	5625	17	peak	peak	NN
cord-001835-0s7ok4uw	5625	18	area	area	NN
cord-001835-0s7ok4uw	5625	19	(	(	-LRB-
cord-001835-0s7ok4uw	5625	20	30	30	CD
cord-001835-0s7ok4uw	5625	21	-	-	SYM
cord-001835-0s7ok4uw	5625	22	90	90	CD
cord-001835-0s7ok4uw	5625	23	%	%	NN
cord-001835-0s7ok4uw	5625	24	)	)	-RRB-
cord-001835-0s7ok4uw	5625	25	for	for	IN
cord-001835-0s7ok4uw	5625	26	all	all	DT
cord-001835-0s7ok4uw	5625	27	HNPs	hnp	NNS
cord-001835-0s7ok4uw	5625	28	.	.	.
cord-001835-0s7ok4uw	5626	1	HNPs	hnp	NNS
cord-001835-0s7ok4uw	5626	2	were	be	VBD
cord-001835-0s7ok4uw	5626	3	extracted	extract	VBN
cord-001835-0s7ok4uw	5626	4	by	by	IN
cord-001835-0s7ok4uw	5626	5	SPE	SPE	NNP
cord-001835-0s7ok4uw	5626	6	with	with	IN
cord-001835-0s7ok4uw	5626	7	a	a	DT
cord-001835-0s7ok4uw	5626	8	recovery	recovery	NN
cord-001835-0s7ok4uw	5626	9	of	of	IN
cord-001835-0s7ok4uw	5626	10	80	80	CD
cord-001835-0s7ok4uw	5626	11	-	-	SYM
cord-001835-0s7ok4uw	5626	12	91	91	CD
cord-001835-0s7ok4uw	5626	13	%	%	NN
cord-001835-0s7ok4uw	5626	14	.	.	.
cord-001835-0s7ok4uw	5627	1	The	the	DT
cord-001835-0s7ok4uw	5627	2	MeOH	MeOH	NNS
cord-001835-0s7ok4uw	5627	3	:	:	:
cord-001835-0s7ok4uw	5627	4	H2O	h2o	NN
cord-001835-0s7ok4uw	5627	5	:	:	:
cord-001835-0s7ok4uw	5627	6	acetic	acetic	JJ
cord-001835-0s7ok4uw	5627	7	acid	acid	NN
cord-001835-0s7ok4uw	5627	8	(	(	-LRB-
cord-001835-0s7ok4uw	5627	9	0.1	0.1	CD
cord-001835-0s7ok4uw	5627	10	%	%	NN
cord-001835-0s7ok4uw	5627	11	)	)	-RRB-
cord-001835-0s7ok4uw	5627	12	provided	provide	VBN
cord-001835-0s7ok4uw	5627	13	enhanced	enhance	VBN
cord-001835-0s7ok4uw	5627	14	(	(	-LRB-
cord-001835-0s7ok4uw	5627	15	P>0.05	p>0.05	JJ
cord-001835-0s7ok4uw	5627	16	)	)	-RRB-
cord-001835-0s7ok4uw	5627	17	HNP1	HNP1	NNP
cord-001835-0s7ok4uw	5627	18	-	-	HYPH
cord-001835-0s7ok4uw	5627	19	3	3	CD
cord-001835-0s7ok4uw	5627	20	ion	ion	NN
cord-001835-0s7ok4uw	5627	21	intensities	intensity	NNS
cord-001835-0s7ok4uw	5627	22	.	.	.
cord-001835-0s7ok4uw	5628	1	The	the	DT
cord-001835-0s7ok4uw	5628	2	Kinetex	Kinetex	NNP
cord-001835-0s7ok4uw	5628	3	V	v	NN
cord-001835-0s7ok4uw	5628	4	R	r	NN
cord-001835-0s7ok4uw	5628	5	C8	c8	NN
cord-001835-0s7ok4uw	5628	6	(	(	-LRB-
cord-001835-0s7ok4uw	5628	7	50	50	CD
cord-001835-0s7ok4uw	5628	8	x	x	SYM
cord-001835-0s7ok4uw	5628	9	3.0	3.0	CD
cord-001835-0s7ok4uw	5628	10	mm	mm	NN
cord-001835-0s7ok4uw	5628	11	,	,	,
cord-001835-0s7ok4uw	5628	12	2.6	2.6	CD
cord-001835-0s7ok4uw	5628	13	mm	mm	NNS
cord-001835-0s7ok4uw	5628	14	)	)	-RRB-
cord-001835-0s7ok4uw	5628	15	column	column	NN
cord-001835-0s7ok4uw	5628	16	facilitated	facilitate	VBD
cord-001835-0s7ok4uw	5628	17	a	a	DT
cord-001835-0s7ok4uw	5628	18	better	well	JJR
cord-001835-0s7ok4uw	5628	19	separation	separation	NN
cord-001835-0s7ok4uw	5628	20	efficiency	efficiency	NN
cord-001835-0s7ok4uw	5628	21	of	of	IN
cord-001835-0s7ok4uw	5628	22	the	the	DT
cord-001835-0s7ok4uw	5628	23	four	four	CD
cord-001835-0s7ok4uw	5628	24	HNPs	hnp	NNS
cord-001835-0s7ok4uw	5628	25	as	as	IN
cord-001835-0s7ok4uw	5628	26	compared	compare	VBN
cord-001835-0s7ok4uw	5628	27	to	to	IN
cord-001835-0s7ok4uw	5628	28	the	the	DT
cord-001835-0s7ok4uw	5628	29	Ultra	Ultra	NNP
cord-001835-0s7ok4uw	5628	30	Core	Core	NNP
cord-001835-0s7ok4uw	5628	31	Super	Super	NNP
cord-001835-0s7ok4uw	5628	32	C18	C18	NNP
cord-001835-0s7ok4uw	5628	33	ACE	ace	NN
cord-001835-0s7ok4uw	5628	34	V	v	NN
cord-001835-0s7ok4uw	5628	35	R	r	NN
cord-001835-0s7ok4uw	5628	36	(	(	-LRB-
cord-001835-0s7ok4uw	5628	37	50	50	CD
cord-001835-0s7ok4uw	5628	38	x	x	SYM
cord-001835-0s7ok4uw	5628	39	3.0	3.0	CD
cord-001835-0s7ok4uw	5628	40	mm	mm	NN
cord-001835-0s7ok4uw	5628	41	,	,	,
cord-001835-0s7ok4uw	5628	42	25	25	CD
cord-001835-0s7ok4uw	5628	43	mm	mm	CD
cord-001835-0s7ok4uw	5628	44	)	)	-RRB-
cord-001835-0s7ok4uw	5628	45	column	column	NN
cord-001835-0s7ok4uw	5628	46	,	,	,
cord-001835-0s7ok4uw	5628	47	the	the	DT
cord-001835-0s7ok4uw	5628	48	Kinetex	Kinetex	NNP
cord-001835-0s7ok4uw	5628	49	V	V	NNP
cord-001835-0s7ok4uw	5628	50	R	R	NNP
cord-001835-0s7ok4uw	5628	51	C18	C18	NNP
cord-001835-0s7ok4uw	5628	52	(	(	-LRB-
cord-001835-0s7ok4uw	5628	53	50	50	CD
cord-001835-0s7ok4uw	5628	54	x	x	SYM
cord-001835-0s7ok4uw	5628	55	3.0	3.0	CD
cord-001835-0s7ok4uw	5628	56	mm	mm	NN
cord-001835-0s7ok4uw	5628	57	,	,	,
cord-001835-0s7ok4uw	5628	58	2.6	2.6	CD
cord-001835-0s7ok4uw	5628	59	mm	mm	NNS
cord-001835-0s7ok4uw	5628	60	)	)	-RRB-
cord-001835-0s7ok4uw	5628	61	and	and	CC
cord-001835-0s7ok4uw	5628	62	the	the	DT
cord-001835-0s7ok4uw	5628	63	Kinetex	Kinetex	NNP
cord-001835-0s7ok4uw	5628	64	V	V	NNP
cord-001835-0s7ok4uw	5628	65	R	R	NNP
cord-001835-0s7ok4uw	5628	66	C18	C18	NNP
cord-001835-0s7ok4uw	5628	67	(	(	-LRB-
cord-001835-0s7ok4uw	5628	68	50	50	CD
cord-001835-0s7ok4uw	5628	69	x	x	SYM
cord-001835-0s7ok4uw	5628	70	3.0	3.0	CD
cord-001835-0s7ok4uw	5628	71	mm	mm	NN
cord-001835-0s7ok4uw	5628	72	,	,	,
cord-001835-0s7ok4uw	5628	73	5	5	CD
cord-001835-0s7ok4uw	5628	74	mm	mm	NNP
cord-001835-0s7ok4uw	5628	75	)	)	-RRB-
cord-001835-0s7ok4uw	5628	76	column	column	NN
cord-001835-0s7ok4uw	5628	77	.	.	.
cord-001835-0s7ok4uw	5629	1	The	the	DT
cord-001835-0s7ok4uw	5629	2	relative	relative	JJ
cord-001835-0s7ok4uw	5629	3	levels	level	NNS
cord-001835-0s7ok4uw	5629	4	of	of	IN
cord-001835-0s7ok4uw	5629	5	the	the	DT
cord-001835-0s7ok4uw	5629	6	HNPs	hnp	NNS
cord-001835-0s7ok4uw	5629	7	were	be	VBD
cord-001835-0s7ok4uw	5629	8	determined	determine	VBN
cord-001835-0s7ok4uw	5629	9	in	in	IN
cord-001835-0s7ok4uw	5629	10	healthy	healthy	JJ
cord-001835-0s7ok4uw	5629	11	volunteers	volunteer	NNS
cord-001835-0s7ok4uw	5629	12	before	before	IN
cord-001835-0s7ok4uw	5629	13	and	and	CC
cord-001835-0s7ok4uw	5629	14	after	after	IN
cord-001835-0s7ok4uw	5629	15	a	a	DT
cord-001835-0s7ok4uw	5629	16	rigorous	rigorous	JJ
cord-001835-0s7ok4uw	5629	17	exercise	exercise	NN
cord-001835-0s7ok4uw	5629	18	regime	regime	NN
cord-001835-0s7ok4uw	5629	19	:	:	:
cord-001835-0s7ok4uw	5629	20	It	-PRON-	PRP
cord-001835-0s7ok4uw	5629	21	is	be	VBZ
cord-001835-0s7ok4uw	5629	22	possible	possible	JJ
cord-001835-0s7ok4uw	5629	23	that	that	IN
cord-001835-0s7ok4uw	5629	24	prolonged	prolong	VBN
cord-001835-0s7ok4uw	5629	25	strenuous	strenuous	JJ
cord-001835-0s7ok4uw	5629	26	exercise	exercise	NN
cord-001835-0s7ok4uw	5629	27	will	will	MD
cord-001835-0s7ok4uw	5629	28	affect	affect	VB
cord-001835-0s7ok4uw	5629	29	oral	oral	JJ
cord-001835-0s7ok4uw	5629	30	innate	innate	JJ
cord-001835-0s7ok4uw	5629	31	immunity	immunity	NN
cord-001835-0s7ok4uw	5629	32	and	and	CC
cord-001835-0s7ok4uw	5629	33	therefore	therefore	RB
cord-001835-0s7ok4uw	5629	34	also	also	RB
cord-001835-0s7ok4uw	5629	35	the	the	DT
cord-001835-0s7ok4uw	5629	36	level	level	NN
cord-001835-0s7ok4uw	5629	37	of	of	IN
cord-001835-0s7ok4uw	5629	38	salivary	salivary	NN
cord-001835-0s7ok4uw	5629	39	defensins	defensin	NNS
cord-001835-0s7ok4uw	5629	40	.	.	.
cord-001835-0s7ok4uw	5630	1	HNP1	HNP1	NNP
cord-001835-0s7ok4uw	5630	2	-	-	HYPH
cord-001835-0s7ok4uw	5630	3	3	3	CD
cord-001835-0s7ok4uw	5630	4	are	be	VBP
cord-001835-0s7ok4uw	5630	5	traditionally	traditionally	RB
cord-001835-0s7ok4uw	5630	6	detected	detect	VBN
cord-001835-0s7ok4uw	5630	7	in	in	IN
cord-001835-0s7ok4uw	5630	8	an	an	DT
cord-001835-0s7ok4uw	5630	9	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5630	10	-	-	HYPH
cord-001835-0s7ok4uw	5630	11	linked	link	VBN
cord-001835-0s7ok4uw	5630	12	immunosorbent	immunosorbent	JJ
cord-001835-0s7ok4uw	5630	13	assay	assay	NN
cord-001835-0s7ok4uw	5630	14	(	(	-LRB-
cord-001835-0s7ok4uw	5630	15	ELISA	ELISA	NNP
cord-001835-0s7ok4uw	5630	16	)	)	-RRB-
cord-001835-0s7ok4uw	5630	17	which	which	WDT
cord-001835-0s7ok4uw	5630	18	does	do	VBZ
cord-001835-0s7ok4uw	5630	19	not	not	RB
cord-001835-0s7ok4uw	5630	20	discriminate	discriminate	VB
cord-001835-0s7ok4uw	5630	21	between	between	IN
cord-001835-0s7ok4uw	5630	22	the	the	DT
cord-001835-0s7ok4uw	5630	23	different	different	JJ
cord-001835-0s7ok4uw	5630	24	HNPs	hnp	NNS
cord-001835-0s7ok4uw	5630	25	due	due	JJ
cord-001835-0s7ok4uw	5630	26	to	to	IN
cord-001835-0s7ok4uw	5630	27	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5630	28	structural	structural	JJ
cord-001835-0s7ok4uw	5630	29	similarities	similarity	NNS
cord-001835-0s7ok4uw	5630	30	.	.	.
cord-001835-0s7ok4uw	5631	1	There	there	EX
cord-001835-0s7ok4uw	5631	2	has	have	VBZ
cord-001835-0s7ok4uw	5631	3	therefore	therefore	RB
cord-001835-0s7ok4uw	5631	4	been	be	VBN
cord-001835-0s7ok4uw	5631	5	a	a	DT
cord-001835-0s7ok4uw	5631	6	need	need	NN
cord-001835-0s7ok4uw	5631	7	to	to	TO
cord-001835-0s7ok4uw	5631	8	develop	develop	VB
cord-001835-0s7ok4uw	5631	9	a	a	DT
cord-001835-0s7ok4uw	5631	10	mass	mass	NN
cord-001835-0s7ok4uw	5631	11	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	5631	12	method	method	NN
cord-001835-0s7ok4uw	5631	13	that	that	WDT
cord-001835-0s7ok4uw	5631	14	will	will	MD
cord-001835-0s7ok4uw	5631	15	discriminate	discriminate	VB
cord-001835-0s7ok4uw	5631	16	between	between	IN
cord-001835-0s7ok4uw	5631	17	the	the	DT
cord-001835-0s7ok4uw	5631	18	defensins	defensin	NNS
cord-001835-0s7ok4uw	5631	19	.	.	.
cord-001835-0s7ok4uw	5632	1	As	as	IN
cord-001835-0s7ok4uw	5632	2	part	part	NN
cord-001835-0s7ok4uw	5632	3	of	of	IN
cord-001835-0s7ok4uw	5632	4	the	the	DT
cord-001835-0s7ok4uw	5632	5	method	method	NN
cord-001835-0s7ok4uw	5632	6	validation	validation	NN
cord-001835-0s7ok4uw	5632	7	,	,	,
cord-001835-0s7ok4uw	5632	8	the	the	DT
cord-001835-0s7ok4uw	5632	9	HNP1	HNP1	NNP
cord-001835-0s7ok4uw	5632	10	-	-	HYPH
cord-001835-0s7ok4uw	5632	11	3	3	CD
cord-001835-0s7ok4uw	5632	12	level	level	NN
cord-001835-0s7ok4uw	5632	13	was	be	VBD
cord-001835-0s7ok4uw	5632	14	determined	determine	VBN
cord-001835-0s7ok4uw	5632	15	by	by	IN
cord-001835-0s7ok4uw	5632	16	ELISA	ELISA	NNP
cord-001835-0s7ok4uw	5632	17	and	and	CC
cord-001835-0s7ok4uw	5632	18	the	the	DT
cord-001835-0s7ok4uw	5632	19	data	datum	NNS
cord-001835-0s7ok4uw	5632	20	was	be	VBD
cord-001835-0s7ok4uw	5632	21	compared	compare	VBN
cord-001835-0s7ok4uw	5632	22	with	with	IN
cord-001835-0s7ok4uw	5632	23	the	the	DT
cord-001835-0s7ok4uw	5632	24	LC	LC	NNP
cord-001835-0s7ok4uw	5632	25	-	-	HYPH
cord-001835-0s7ok4uw	5632	26	MS	MS	NNP
cord-001835-0s7ok4uw	5632	27	data	datum	NNS
cord-001835-0s7ok4uw	5632	28	.	.	.
cord-001835-0s7ok4uw	5633	1	Here	here	RB
cord-001835-0s7ok4uw	5633	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	5633	3	present	present	VBP
cord-001835-0s7ok4uw	5633	4	this	this	DT
cord-001835-0s7ok4uw	5633	5	cross	cross	NN
cord-001835-0s7ok4uw	5633	6	-	-	NN
cord-001835-0s7ok4uw	5633	7	validation	validation	NN
cord-001835-0s7ok4uw	5633	8	;	;	:
cord-001835-0s7ok4uw	5633	9	the	the	DT
cord-001835-0s7ok4uw	5633	10	data	datum	NNS
cord-001835-0s7ok4uw	5633	11	revealed	reveal	VBD
cord-001835-0s7ok4uw	5633	12	no	no	DT
cord-001835-0s7ok4uw	5633	13	significance	significance	NN
cord-001835-0s7ok4uw	5633	14	difference	difference	NN
cord-001835-0s7ok4uw	5633	15	between	between	IN
cord-001835-0s7ok4uw	5633	16	the	the	DT
cord-001835-0s7ok4uw	5633	17	two	two	CD
cord-001835-0s7ok4uw	5633	18	methods	method	NNS
cord-001835-0s7ok4uw	5633	19	(	(	-LRB-
cord-001835-0s7ok4uw	5633	20	R25	R25	NNP
cord-001835-0s7ok4uw	5633	21	0.96	0.96	CD
cord-001835-0s7ok4uw	5633	22	)	)	-RRB-
cord-001835-0s7ok4uw	5633	23	which	which	WDT
cord-001835-0s7ok4uw	5633	24	confirms	confirm	VBZ
cord-001835-0s7ok4uw	5633	25	that	that	IN
cord-001835-0s7ok4uw	5633	26	the	the	DT
cord-001835-0s7ok4uw	5633	27	developed	develop	VBN
cord-001835-0s7ok4uw	5633	28	LC	LC	NNP
cord-001835-0s7ok4uw	5633	29	-	-	HYPH
cord-001835-0s7ok4uw	5633	30	MS	MS	NNP
cord-001835-0s7ok4uw	5633	31	method	method	NN
cord-001835-0s7ok4uw	5633	32	is	be	VBZ
cord-001835-0s7ok4uw	5633	33	and	and	CC
cord-001835-0s7ok4uw	5633	34	equal	equal	JJ
cord-001835-0s7ok4uw	5633	35	sensitive	sensitive	JJ
cord-001835-0s7ok4uw	5633	36	method	method	NN
cord-001835-0s7ok4uw	5633	37	for	for	IN
cord-001835-0s7ok4uw	5633	38	the	the	DT
cord-001835-0s7ok4uw	5633	39	detection	detection	NN
cord-001835-0s7ok4uw	5633	40	of	of	IN
cord-001835-0s7ok4uw	5633	41	these	these	DT
cord-001835-0s7ok4uw	5633	42	potential	potential	JJ
cord-001835-0s7ok4uw	5633	43	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5633	44	markers	marker	NNS
cord-001835-0s7ok4uw	5633	45	.	.	.
cord-001835-0s7ok4uw	5634	1	This	this	DT
cord-001835-0s7ok4uw	5634	2	method	method	NN
cord-001835-0s7ok4uw	5634	3	can	can	MD
cord-001835-0s7ok4uw	5634	4	easily	easily	RB
cord-001835-0s7ok4uw	5634	5	be	be	VB
cord-001835-0s7ok4uw	5634	6	adopted	adopt	VBN
cord-001835-0s7ok4uw	5634	7	for	for	IN
cord-001835-0s7ok4uw	5634	8	similar	similar	JJ
cord-001835-0s7ok4uw	5634	9	molecular	molecular	JJ
cord-001835-0s7ok4uw	5634	10	weight	weight	NN
cord-001835-0s7ok4uw	5634	11	of	of	IN
cord-001835-0s7ok4uw	5634	12	peptides	peptide	NNS
cord-001835-0s7ok4uw	5634	13	as	as	IN
cord-001835-0s7ok4uw	5634	14	HNPs	hnp	NNS
cord-001835-0s7ok4uw	5634	15	and	and	CC
cord-001835-0s7ok4uw	5634	16	also	also	RB
cord-001835-0s7ok4uw	5634	17	for	for	IN
cord-001835-0s7ok4uw	5634	18	any	any	DT
cord-001835-0s7ok4uw	5634	19	other	other	JJ
cord-001835-0s7ok4uw	5634	20	biological	biological	JJ
cord-001835-0s7ok4uw	5634	21	matrix	matrix	NN
cord-001835-0s7ok4uw	5634	22	.	.	.
cord-001835-0s7ok4uw	5635	1	Moonlighting	moonlight	VBG
cord-001835-0s7ok4uw	5635	2	proteins	protein	NNS
cord-001835-0s7ok4uw	5635	3	:	:	:
cord-001835-0s7ok4uw	5635	4	relevance	relevance	NN
cord-001835-0s7ok4uw	5635	5	for	for	IN
cord-001835-0s7ok4uw	5635	6	biotechnology	biotechnology	NN
cord-001835-0s7ok4uw	5635	7	and	and	CC
cord-001835-0s7ok4uw	5635	8	biomedicine	biomedicine	NN
cord-001835-0s7ok4uw	5636	1	Luis	Luis	NNP
cord-001835-0s7ok4uw	5636	2	Franco	Franco	NNP
cord-001835-0s7ok4uw	5636	3	Serrano	Serrano	NNP
cord-001835-0s7ok4uw	5636	4	1	1	CD
cord-001835-0s7ok4uw	5636	5	,	,	,
cord-001835-0s7ok4uw	5636	6	Sergio	Sergio	NNP
cord-001835-0s7ok4uw	5636	7	Hern	Hern	NNP
cord-001835-0s7ok4uw	5637	1	andez	andez	NNP
cord-001835-0s7ok4uw	5637	2	1	1	CD
cord-001835-0s7ok4uw	5637	3	,	,	,
cord-001835-0s7ok4uw	5637	4	Alejandra	Alejandra	NNP
cord-001835-0s7ok4uw	5637	5	Calvo	Calvo	NNP
cord-001835-0s7ok4uw	5637	6	2	2	CD
cord-001835-0s7ok4uw	5637	7	,	,	,
cord-001835-0s7ok4uw	5637	8	Gabriela	Gabriela	NNP
cord-001835-0s7ok4uw	5637	9	Ferragut	Ferragut	NNP
cord-001835-0s7ok4uw	5637	10	2	2	CD
cord-001835-0s7ok4uw	5637	11	,	,	,
cord-001835-0s7ok4uw	5637	12	Isaac	Isaac	NNP
cord-001835-0s7ok4uw	5637	13	Amela	Amela	NNP
cord-001835-0s7ok4uw	5637	14	1	1	CD
cord-001835-0s7ok4uw	5637	15	,	,	,
cord-001835-0s7ok4uw	5637	16	Juan	Juan	NNP
cord-001835-0s7ok4uw	5637	17	Cedano	Cedano	NNP
cord-001835-0s7ok4uw	5637	18	2	2	CD
cord-001835-0s7ok4uw	5638	1	,	,	,
cord-001835-0s7ok4uw	5638	2	Enrique	Enrique	NNP
cord-001835-0s7ok4uw	5638	3	Querol	Querol	NNP
cord-001835-0s7ok4uw	5638	4	1	1	CD
cord-001835-0s7ok4uw	5638	5	1	1	CD
cord-001835-0s7ok4uw	5638	6	Institut	Institut	NNP
cord-001835-0s7ok4uw	5638	7	de	de	IN
cord-001835-0s7ok4uw	5638	8	Biotecnologia	Biotecnologia	NNP
cord-001835-0s7ok4uw	5639	1	i	i	PRP
cord-001835-0s7ok4uw	5639	2	Biomedicina	Biomedicina	NNP
cord-001835-0s7ok4uw	5639	3	.	.	.
cord-001835-0s7ok4uw	5640	1	Universitat	Universitat	NNP
cord-001835-0s7ok4uw	5640	2	Aut	Aut	NNP
cord-001835-0s7ok4uw	5640	3	onoma	onoma	NN
cord-001835-0s7ok4uw	5640	4	de	de	NNP
cord-001835-0s7ok4uw	5640	5	Barcelona	Barcelona	NNP
cord-001835-0s7ok4uw	5640	6	,	,	,
cord-001835-0s7ok4uw	5641	1	2	2	LS
cord-001835-0s7ok4uw	5641	2	Laboratorio	Laboratorio	NNP
cord-001835-0s7ok4uw	5641	3	de	de	NNP
cord-001835-0s7ok4uw	5641	4	Inmunolog	Inmunolog	NNP
cord-001835-0s7ok4uw	5641	5	ıa	ıa	NNS
cord-001835-0s7ok4uw	5641	6	,	,	,
cord-001835-0s7ok4uw	5641	7	Universidad	Universidad	NNP
cord-001835-0s7ok4uw	5641	8	de	de	NNP
cord-001835-0s7ok4uw	5641	9	la	la	NNP
cord-001835-0s7ok4uw	5641	10	Rep	Rep	NNP
cord-001835-0s7ok4uw	5641	11	ublica	ublica	NNP
cord-001835-0s7ok4uw	5641	12	Regional	Regional	NNP
cord-001835-0s7ok4uw	5641	13	Norte	Norte	NNP
cord-001835-0s7ok4uw	5641	14	-	-	HYPH
cord-001835-0s7ok4uw	5641	15	Salto	Salto	NNP
cord-001835-0s7ok4uw	5641	16	Multitasking	Multitasking	NNP
cord-001835-0s7ok4uw	5641	17	or	or	CC
cord-001835-0s7ok4uw	5641	18	moonlighting	moonlighting	NN
cord-001835-0s7ok4uw	5641	19	is	be	VBZ
cord-001835-0s7ok4uw	5641	20	the	the	DT
cord-001835-0s7ok4uw	5641	21	capability	capability	NN
cord-001835-0s7ok4uw	5641	22	of	of	IN
cord-001835-0s7ok4uw	5641	23	some	some	DT
cord-001835-0s7ok4uw	5641	24	proteins	protein	NNS
cord-001835-0s7ok4uw	5641	25	to	to	TO
cord-001835-0s7ok4uw	5641	26	execute	execute	VB
cord-001835-0s7ok4uw	5641	27	two	two	CD
cord-001835-0s7ok4uw	5641	28	or	or	CC
cord-001835-0s7ok4uw	5641	29	more	more	JJR
cord-001835-0s7ok4uw	5641	30	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5641	31	functions	function	NNS
cord-001835-0s7ok4uw	5641	32	.	.	.
cord-001835-0s7ok4uw	5642	1	The	the	DT
cord-001835-0s7ok4uw	5642	2	identification	identification	NN
cord-001835-0s7ok4uw	5642	3	of	of	IN
cord-001835-0s7ok4uw	5642	4	moonlighting	moonlight	VBG
cord-001835-0s7ok4uw	5642	5	proteins	protein	NNS
cord-001835-0s7ok4uw	5642	6	could	could	MD
cord-001835-0s7ok4uw	5642	7	be	be	VB
cord-001835-0s7ok4uw	5642	8	useful	useful	JJ
cord-001835-0s7ok4uw	5642	9	for	for	IN
cord-001835-0s7ok4uw	5642	10	researchers	researcher	NNS
cord-001835-0s7ok4uw	5642	11	in	in	IN
cord-001835-0s7ok4uw	5642	12	the	the	DT
cord-001835-0s7ok4uw	5642	13	functional	functional	JJ
cord-001835-0s7ok4uw	5642	14	annotation	annotation	NN
cord-001835-0s7ok4uw	5642	15	of	of	IN
cord-001835-0s7ok4uw	5642	16	new	new	JJ
cord-001835-0s7ok4uw	5642	17	genomes	genome	NNS
cord-001835-0s7ok4uw	5642	18	.	.	.
cord-001835-0s7ok4uw	5643	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	5643	2	,	,	,
cord-001835-0s7ok4uw	5643	3	the	the	DT
cord-001835-0s7ok4uw	5643	4	interpretation	interpretation	NN
cord-001835-0s7ok4uw	5643	5	of	of	IN
cord-001835-0s7ok4uw	5643	6	knockout	knockout	NN
cord-001835-0s7ok4uw	5643	7	experiments	experiment	NNS
cord-001835-0s7ok4uw	5643	8	,	,	,
cord-001835-0s7ok4uw	5643	9	in	in	IN
cord-001835-0s7ok4uw	5643	10	which	which	WDT
cord-001835-0s7ok4uw	5643	11	the	the	DT
cord-001835-0s7ok4uw	5643	12	result	result	NN
cord-001835-0s7ok4uw	5643	13	of	of	IN
cord-001835-0s7ok4uw	5643	14	a	a	DT
cord-001835-0s7ok4uw	5643	15	gene	gene	NN
cord-001835-0s7ok4uw	5643	16	knocking	knocking	NN
cord-001835-0s7ok4uw	5643	17	does	do	VBZ
cord-001835-0s7ok4uw	5643	18	not	not	RB
cord-001835-0s7ok4uw	5643	19	produce	produce	VB
cord-001835-0s7ok4uw	5643	20	the	the	DT
cord-001835-0s7ok4uw	5643	21	expected	expect	VBN
cord-001835-0s7ok4uw	5643	22	results	result	NNS
cord-001835-0s7ok4uw	5643	23	,	,	,
cord-001835-0s7ok4uw	5643	24	might	may	MD
cord-001835-0s7ok4uw	5643	25	be	be	VB
cord-001835-0s7ok4uw	5643	26	enhanced	enhance	VBN
cord-001835-0s7ok4uw	5643	27	.	.	.
cord-001835-0s7ok4uw	5644	1	The	the	DT
cord-001835-0s7ok4uw	5644	2	action	action	NN
cord-001835-0s7ok4uw	5644	3	of	of	IN
cord-001835-0s7ok4uw	5644	4	a	a	DT
cord-001835-0s7ok4uw	5644	5	drug	drug	NN
cord-001835-0s7ok4uw	5644	6	can	can	MD
cord-001835-0s7ok4uw	5644	7	also	also	RB
cord-001835-0s7ok4uw	5644	8	be	be	VB
cord-001835-0s7ok4uw	5644	9	facilitated	facilitate	VBN
cord-001835-0s7ok4uw	5644	10	because	because	IN
cord-001835-0s7ok4uw	5644	11	it	-PRON-	PRP
cord-001835-0s7ok4uw	5644	12	might	may	MD
cord-001835-0s7ok4uw	5644	13	have	have	VB
cord-001835-0s7ok4uw	5644	14	an	an	DT
cord-001835-0s7ok4uw	5644	15	off	off	JJ
cord-001835-0s7ok4uw	5644	16	-	-	HYPH
cord-001835-0s7ok4uw	5644	17	target	target	NN
cord-001835-0s7ok4uw	5644	18	or	or	CC
cord-001835-0s7ok4uw	5644	19	side	side	NN
cord-001835-0s7ok4uw	5644	20	effect	effect	NN
cord-001835-0s7ok4uw	5644	21	with	with	IN
cord-001835-0s7ok4uw	5644	22	somewhat	somewhat	RB
cord-001835-0s7ok4uw	5644	23	hidden	hide	VBN
cord-001835-0s7ok4uw	5644	24	phenotypic	phenotypic	JJ
cord-001835-0s7ok4uw	5644	25	traits	trait	NNS
cord-001835-0s7ok4uw	5644	26	.	.	.
cord-001835-0s7ok4uw	5645	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5645	2	would	would	MD
cord-001835-0s7ok4uw	5645	3	be	be	VB
cord-001835-0s7ok4uw	5645	4	helpful	helpful	JJ
cord-001835-0s7ok4uw	5645	5	that	that	IN
cord-001835-0s7ok4uw	5645	6	Bioinformatics	Bioinformatics	NNP
cord-001835-0s7ok4uw	5645	7	could	could	MD
cord-001835-0s7ok4uw	5645	8	predict	predict	VB
cord-001835-0s7ok4uw	5645	9	this	this	DT
cord-001835-0s7ok4uw	5645	10	multifunctionality	multifunctionality	NN
cord-001835-0s7ok4uw	5645	11	.	.	.
cord-001835-0s7ok4uw	5646	1	In	in	IN
cord-001835-0s7ok4uw	5646	2	the	the	DT
cord-001835-0s7ok4uw	5646	3	present	present	JJ
cord-001835-0s7ok4uw	5646	4	work	work	NN
cord-001835-0s7ok4uw	5646	5	,	,	,
cord-001835-0s7ok4uw	5646	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	5646	7	analyse	analyse	VBP
cord-001835-0s7ok4uw	5646	8	and	and	CC
cord-001835-0s7ok4uw	5646	9	describe	describe	VBP
cord-001835-0s7ok4uw	5646	10	several	several	JJ
cord-001835-0s7ok4uw	5646	11	approaches	approach	NNS
cord-001835-0s7ok4uw	5646	12	that	that	WDT
cord-001835-0s7ok4uw	5646	13	use	use	VBP
cord-001835-0s7ok4uw	5646	14	protein	protein	NN
cord-001835-0s7ok4uw	5646	15	sequences	sequence	NNS
cord-001835-0s7ok4uw	5646	16	,	,	,
cord-001835-0s7ok4uw	5646	17	structures	structure	NNS
cord-001835-0s7ok4uw	5646	18	,	,	,
cord-001835-0s7ok4uw	5646	19	interactomics	interactomic	NNS
cord-001835-0s7ok4uw	5646	20	and	and	CC
cord-001835-0s7ok4uw	5646	21	current	current	JJ
cord-001835-0s7ok4uw	5646	22	bioinformatics	bioinformatics	NN
cord-001835-0s7ok4uw	5646	23	algorithms	algorithm	NNS
cord-001835-0s7ok4uw	5646	24	and	and	CC
cord-001835-0s7ok4uw	5646	25	programs	program	NNS
cord-001835-0s7ok4uw	5646	26	to	to	TO
cord-001835-0s7ok4uw	5646	27	try	try	VB
cord-001835-0s7ok4uw	5646	28	to	to	TO
cord-001835-0s7ok4uw	5646	29	overcome	overcome	VB
cord-001835-0s7ok4uw	5646	30	this	this	DT
cord-001835-0s7ok4uw	5646	31	problem	problem	NN
cord-001835-0s7ok4uw	5646	32	.	.	.
cord-001835-0s7ok4uw	5647	1	Among	among	IN
cord-001835-0s7ok4uw	5647	2	these	these	DT
cord-001835-0s7ok4uw	5647	3	approaches	approach	NNS
cord-001835-0s7ok4uw	5647	4	there	there	EX
cord-001835-0s7ok4uw	5647	5	are	be	VBP
cord-001835-0s7ok4uw	5647	6	:	:	:
cord-001835-0s7ok4uw	5647	7	a	a	LS
cord-001835-0s7ok4uw	5647	8	)	)	-RRB-
cord-001835-0s7ok4uw	5647	9	remote	remote	JJ
cord-001835-0s7ok4uw	5647	10	homology	homology	NN
cord-001835-0s7ok4uw	5647	11	searches	search	NNS
cord-001835-0s7ok4uw	5647	12	using	use	VBG
cord-001835-0s7ok4uw	5647	13	Psi	Psi	NNP
cord-001835-0s7ok4uw	5647	14	-	-	HYPH
cord-001835-0s7ok4uw	5647	15	Blast	blast	NN
cord-001835-0s7ok4uw	5647	16	,	,	,
cord-001835-0s7ok4uw	5647	17	b	b	LS
cord-001835-0s7ok4uw	5647	18	)	)	-RRB-
cord-001835-0s7ok4uw	5647	19	detection	detection	NN
cord-001835-0s7ok4uw	5647	20	of	of	IN
cord-001835-0s7ok4uw	5647	21	functional	functional	JJ
cord-001835-0s7ok4uw	5647	22	motifs	motif	NNS
cord-001835-0s7ok4uw	5647	23	and	and	CC
cord-001835-0s7ok4uw	5647	24	domains	domain	NNS
cord-001835-0s7ok4uw	5647	25	,	,	,
cord-001835-0s7ok4uw	5647	26	c	c	NN
cord-001835-0s7ok4uw	5647	27	)	)	-RRB-
cord-001835-0s7ok4uw	5647	28	analysis	analysis	NN
cord-001835-0s7ok4uw	5647	29	of	of	IN
cord-001835-0s7ok4uw	5647	30	data	datum	NNS
cord-001835-0s7ok4uw	5647	31	obtained	obtain	VBN
cord-001835-0s7ok4uw	5647	32	of	of	IN
cord-001835-0s7ok4uw	5647	33	protein	protein	NN
cord-001835-0s7ok4uw	5647	34	-	-	HYPH
cord-001835-0s7ok4uw	5647	35	protein	protein	NN
cord-001835-0s7ok4uw	5647	36	interaction	interaction	NN
cord-001835-0s7ok4uw	5647	37	databases	database	NNS
cord-001835-0s7ok4uw	5647	38	(	(	-LRB-
cord-001835-0s7ok4uw	5647	39	PPIs	ppi	NNS
cord-001835-0s7ok4uw	5647	40	)	)	-RRB-
cord-001835-0s7ok4uw	5647	41	,	,	,
cord-001835-0s7ok4uw	5647	42	d	d	LS
cord-001835-0s7ok4uw	5647	43	)	)	-RRB-
cord-001835-0s7ok4uw	5647	44	matches	match	NNS
cord-001835-0s7ok4uw	5647	45	of	of	IN
cord-001835-0s7ok4uw	5647	46	the	the	DT
cord-001835-0s7ok4uw	5647	47	sequence	sequence	NN
cord-001835-0s7ok4uw	5647	48	of	of	IN
cord-001835-0s7ok4uw	5647	49	the	the	DT
cord-001835-0s7ok4uw	5647	50	query	query	NN
cord-001835-0s7ok4uw	5647	51	protein	protein	NN
cord-001835-0s7ok4uw	5647	52	to	to	IN
cord-001835-0s7ok4uw	5647	53	3D	3d	JJ
cord-001835-0s7ok4uw	5647	54	databases	database	NNS
cord-001835-0s7ok4uw	5647	55	(	(	-LRB-
cord-001835-0s7ok4uw	5647	56	i.e.	i.e.	FW
cord-001835-0s7ok4uw	5647	57	,	,	,
cord-001835-0s7ok4uw	5647	58	algorithms	algorithm	NNS
cord-001835-0s7ok4uw	5647	59	like	like	IN
cord-001835-0s7ok4uw	5647	60	PISITE	PISITE	NNP
cord-001835-0s7ok4uw	5647	61	)	)	-RRB-
cord-001835-0s7ok4uw	5647	62	,	,	,
cord-001835-0s7ok4uw	5647	63	e	e	LS
cord-001835-0s7ok4uw	5647	64	)	)	-RRB-
cord-001835-0s7ok4uw	5647	65	mutation	mutation	NN
cord-001835-0s7ok4uw	5647	66	correlation	correlation	NN
cord-001835-0s7ok4uw	5647	67	analysis	analysis	NN
cord-001835-0s7ok4uw	5647	68	between	between	IN
cord-001835-0s7ok4uw	5647	69	amino	amino	NN
cord-001835-0s7ok4uw	5647	70	acids	acid	NNS
cord-001835-0s7ok4uw	5647	71	using	use	VBG
cord-001835-0s7ok4uw	5647	72	algorithms	algorithm	NNS
cord-001835-0s7ok4uw	5647	73	like	like	IN
cord-001835-0s7ok4uw	5647	74	MISTIC	MISTIC	NNP
cord-001835-0s7ok4uw	5647	75	.	.	.
cord-001835-0s7ok4uw	5648	1	Remote	remote	JJ
cord-001835-0s7ok4uw	5648	2	homology	homology	NN
cord-001835-0s7ok4uw	5648	3	searches	search	NNS
cord-001835-0s7ok4uw	5648	4	using	use	VBG
cord-001835-0s7ok4uw	5648	5	Psi	Psi	NNP
cord-001835-0s7ok4uw	5648	6	-	-	HYPH
cord-001835-0s7ok4uw	5648	7	Blast	blast	NN
cord-001835-0s7ok4uw	5648	8	combined	combine	VBN
cord-001835-0s7ok4uw	5648	9	with	with	IN
cord-001835-0s7ok4uw	5648	10	data	datum	NNS
cord-001835-0s7ok4uw	5648	11	obtained	obtain	VBN
cord-001835-0s7ok4uw	5648	12	from	from	IN
cord-001835-0s7ok4uw	5648	13	interactomics	interactomic	NNS
cord-001835-0s7ok4uw	5648	14	databases	database	NNS
cord-001835-0s7ok4uw	5648	15	(	(	-LRB-
cord-001835-0s7ok4uw	5648	16	PPIs	ppi	NNS
cord-001835-0s7ok4uw	5648	17	)	)	-RRB-
cord-001835-0s7ok4uw	5648	18	have	have	VBP
cord-001835-0s7ok4uw	5648	19	the	the	DT
cord-001835-0s7ok4uw	5648	20	best	good	JJS
cord-001835-0s7ok4uw	5648	21	performance	performance	NN
cord-001835-0s7ok4uw	5648	22	.	.	.
cord-001835-0s7ok4uw	5649	1	Structural	structural	JJ
cord-001835-0s7ok4uw	5649	2	information	information	NN
cord-001835-0s7ok4uw	5649	3	and	and	CC
cord-001835-0s7ok4uw	5649	4	mutation	mutation	NN
cord-001835-0s7ok4uw	5649	5	correlation	correlation	NN
cord-001835-0s7ok4uw	5649	6	analysis	analysis	NN
cord-001835-0s7ok4uw	5649	7	can	can	MD
cord-001835-0s7ok4uw	5649	8	help	help	VB
cord-001835-0s7ok4uw	5649	9	us	-PRON-	PRP
cord-001835-0s7ok4uw	5649	10	to	to	TO
cord-001835-0s7ok4uw	5649	11	map	map	VB
cord-001835-0s7ok4uw	5649	12	the	the	DT
cord-001835-0s7ok4uw	5649	13	functional	functional	JJ
cord-001835-0s7ok4uw	5649	14	sites	site	NNS
cord-001835-0s7ok4uw	5649	15	.	.	.
cord-001835-0s7ok4uw	5650	1	Mutation	mutation	NN
cord-001835-0s7ok4uw	5650	2	correlation	correlation	NN
cord-001835-0s7ok4uw	5650	3	analysis	analysis	NN
cord-001835-0s7ok4uw	5650	4	can	can	MD
cord-001835-0s7ok4uw	5650	5	only	only	RB
cord-001835-0s7ok4uw	5650	6	be	be	VB
cord-001835-0s7ok4uw	5650	7	used	use	VBN
cord-001835-0s7ok4uw	5650	8	in	in	IN
cord-001835-0s7ok4uw	5650	9	very	very	RB
cord-001835-0s7ok4uw	5650	10	specific	specific	JJ
cord-001835-0s7ok4uw	5650	11	situations	situation	NNS
cord-001835-0s7ok4uw	5650	12	because	because	IN
cord-001835-0s7ok4uw	5650	13	it	-PRON-	PRP
cord-001835-0s7ok4uw	5650	14	requires	require	VBZ
cord-001835-0s7ok4uw	5650	15	the	the	DT
cord-001835-0s7ok4uw	5650	16	existence	existence	NN
cord-001835-0s7ok4uw	5650	17	of	of	IN
cord-001835-0s7ok4uw	5650	18	a	a	DT
cord-001835-0s7ok4uw	5650	19	multialigned	multialigned	JJ
cord-001835-0s7ok4uw	5650	20	family	family	NN
cord-001835-0s7ok4uw	5650	21	of	of	IN
cord-001835-0s7ok4uw	5650	22	protein	protein	NN
cord-001835-0s7ok4uw	5650	23	sequences	sequence	NNS
cord-001835-0s7ok4uw	5650	24	,	,	,
cord-001835-0s7ok4uw	5650	25	but	but	CC
cord-001835-0s7ok4uw	5650	26	it	-PRON-	PRP
cord-001835-0s7ok4uw	5650	27	can	can	MD
cord-001835-0s7ok4uw	5650	28	suggest	suggest	VB
cord-001835-0s7ok4uw	5650	29	how	how	WRB
cord-001835-0s7ok4uw	5650	30	the	the	DT
cord-001835-0s7ok4uw	5650	31	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	5650	32	process	process	NN
cord-001835-0s7ok4uw	5650	33	of	of	IN
cord-001835-0s7ok4uw	5650	34	second	second	JJ
cord-001835-0s7ok4uw	5650	35	function	function	NN
cord-001835-0s7ok4uw	5650	36	acquisition	acquisition	NN
cord-001835-0s7ok4uw	5650	37	took	take	VBD
cord-001835-0s7ok4uw	5650	38	place	place	NN
cord-001835-0s7ok4uw	5650	39	.	.	.
cord-001835-0s7ok4uw	5651	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5651	2	have	have	VBP
cord-001835-0s7ok4uw	5651	3	designed	design	VBN
cord-001835-0s7ok4uw	5651	4	a	a	DT
cord-001835-0s7ok4uw	5651	5	database	database	NN
cord-001835-0s7ok4uw	5651	6	of	of	IN
cord-001835-0s7ok4uw	5651	7	moonlighting	moonlight	VBG
cord-001835-0s7ok4uw	5651	8	proteins	protein	NNS
cord-001835-0s7ok4uw	5651	9	,	,	,
cord-001835-0s7ok4uw	5651	10	MultitaskProtDB	MultitaskProtDB	NNP
cord-001835-0s7ok4uw	5651	11	(	(	-LRB-
cord-001835-0s7ok4uw	5651	12	http://	http://	NNP
cord-001835-0s7ok4uw	5651	13	wallace.uab.es/multitask/	wallace.uab.es/multitask/	NNP
cord-001835-0s7ok4uw	5651	14	)	)	-RRB-
cord-001835-0s7ok4uw	5651	15	.	.	.
cord-001835-0s7ok4uw	5652	1	From	from	IN
cord-001835-0s7ok4uw	5652	2	this	this	DT
cord-001835-0s7ok4uw	5652	3	database	database	NN
cord-001835-0s7ok4uw	5652	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	5652	5	determine	determine	VBP
cord-001835-0s7ok4uw	5652	6	the	the	DT
cord-001835-0s7ok4uw	5652	7	frequencies	frequency	NNS
cord-001835-0s7ok4uw	5652	8	of	of	IN
cord-001835-0s7ok4uw	5652	9	canonical	canonical	JJ
cord-001835-0s7ok4uw	5652	10	and	and	CC
cord-001835-0s7ok4uw	5652	11	moonlighting	moonlight	VBG
cord-001835-0s7ok4uw	5652	12	coupled	couple	VBN
cord-001835-0s7ok4uw	5652	13	functions	function	NNS
cord-001835-0s7ok4uw	5652	14	(	(	-LRB-
cord-001835-0s7ok4uw	5652	15	being	be	VBG
cord-001835-0s7ok4uw	5652	16	an	an	DT
cord-001835-0s7ok4uw	5652	17	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5652	18	and	and	CC
cord-001835-0s7ok4uw	5652	19	a	a	DT
cord-001835-0s7ok4uw	5652	20	transcription	transcription	NN
cord-001835-0s7ok4uw	5652	21	factor	factor	NN
cord-001835-0s7ok4uw	5652	22	the	the	DT
cord-001835-0s7ok4uw	5652	23	highest	high	JJS
cord-001835-0s7ok4uw	5652	24	)	)	-RRB-
cord-001835-0s7ok4uw	5652	25	,	,	,
cord-001835-0s7ok4uw	5652	26	the	the	DT
cord-001835-0s7ok4uw	5652	27	percentage	percentage	NN
cord-001835-0s7ok4uw	5652	28	of	of	IN
cord-001835-0s7ok4uw	5652	29	moonlighting	moonlight	VBG
cord-001835-0s7ok4uw	5652	30	proteins	protein	NNS
cord-001835-0s7ok4uw	5652	31	involved	involve	VBN
cord-001835-0s7ok4uw	5652	32	in	in	IN
cord-001835-0s7ok4uw	5652	33	human	human	JJ
cord-001835-0s7ok4uw	5652	34	diseases	disease	NNS
cord-001835-0s7ok4uw	5652	35	(	(	-LRB-
cord-001835-0s7ok4uw	5652	36	65	65	CD
cord-001835-0s7ok4uw	5652	37	%	%	NN
cord-001835-0s7ok4uw	5652	38	of	of	IN
cord-001835-0s7ok4uw	5652	39	the	the	DT
cord-001835-0s7ok4uw	5652	40	human	human	JJ
cord-001835-0s7ok4uw	5652	41	moonlighting	moonlight	VBG
cord-001835-0s7ok4uw	5652	42	proteins	protein	NNS
cord-001835-0s7ok4uw	5652	43	in	in	IN
cord-001835-0s7ok4uw	5652	44	the	the	DT
cord-001835-0s7ok4uw	5652	45	database	database	NN
cord-001835-0s7ok4uw	5652	46	)	)	-RRB-
cord-001835-0s7ok4uw	5652	47	and	and	CC
cord-001835-0s7ok4uw	5652	48	the	the	DT
cord-001835-0s7ok4uw	5652	49	percentage	percentage	NN
cord-001835-0s7ok4uw	5652	50	of	of	IN
cord-001835-0s7ok4uw	5652	51	moonlighting	moonlight	VBG
cord-001835-0s7ok4uw	5652	52	proteins	protein	NNS
cord-001835-0s7ok4uw	5652	53	acting	act	VBG
cord-001835-0s7ok4uw	5652	54	as	as	IN
cord-001835-0s7ok4uw	5652	55	a	a	DT
cord-001835-0s7ok4uw	5652	56	pathogen	pathogen	NN
cord-001835-0s7ok4uw	5652	57	virulence	virulence	NN
cord-001835-0s7ok4uw	5652	58	factor	factor	NN
cord-001835-0s7ok4uw	5652	59	(	(	-LRB-
cord-001835-0s7ok4uw	5652	60	20	20	CD
cord-001835-0s7ok4uw	5652	61	%	%	NN
cord-001835-0s7ok4uw	5652	62	of	of	IN
cord-001835-0s7ok4uw	5652	63	the	the	DT
cord-001835-0s7ok4uw	5652	64	moonlighting	moonlight	VBG
cord-001835-0s7ok4uw	5652	65	proteins	protein	NNS
cord-001835-0s7ok4uw	5652	66	in	in	IN
cord-001835-0s7ok4uw	5652	67	the	the	DT
cord-001835-0s7ok4uw	5652	68	database	database	NN
cord-001835-0s7ok4uw	5652	69	)	)	-RRB-
cord-001835-0s7ok4uw	5652	70	.	.	.
cord-001835-0s7ok4uw	5653	1	Correlation	correlation	NN
cord-001835-0s7ok4uw	5653	2	between	between	IN
cord-001835-0s7ok4uw	5653	3	potential	potential	JJ
cord-001835-0s7ok4uw	5653	4	human	human	JJ
cord-001835-0s7ok4uw	5653	5	neutrophil	neutrophil	NN
cord-001835-0s7ok4uw	5653	6	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5653	7	peptides	peptide	NNS
cord-001835-0s7ok4uw	5653	8	(	(	-LRB-
cord-001835-0s7ok4uw	5653	9	HNP	HNP	NNP
cord-001835-0s7ok4uw	5653	10	1	1	CD
cord-001835-0s7ok4uw	5653	11	-	-	SYM
cord-001835-0s7ok4uw	5653	12	3	3	CD
cord-001835-0s7ok4uw	5653	13	)	)	-RRB-
cord-001835-0s7ok4uw	5653	14	and	and	CC
cord-001835-0s7ok4uw	5653	15	stress	stress	NN
cord-001835-0s7ok4uw	5653	16	hormones	hormone	NNS
cord-001835-0s7ok4uw	5653	17	in	in	IN
cord-001835-0s7ok4uw	5653	18	human	human	JJ
cord-001835-0s7ok4uw	5653	19	saliva	saliva	NN
cord-001835-0s7ok4uw	5653	20	Nadia	Nadia	NNP
cord-001835-0s7ok4uw	5653	21	Ashrafi	Ashrafi	NNP
cord-001835-0s7ok4uw	5653	22	1	1	CD
cord-001835-0s7ok4uw	5653	23	,	,	,
cord-001835-0s7ok4uw	5653	24	Frank	Frank	NNP
cord-001835-0s7ok4uw	5653	25	Pullen	Pullen	NNP
cord-001835-0s7ok4uw	5653	26	1	1	CD
cord-001835-0s7ok4uw	5653	27	,	,	,
cord-001835-0s7ok4uw	5653	28	Birthe	Birthe	NNP
cord-001835-0s7ok4uw	5653	29	Nielse	Nielse	NNP
cord-001835-0s7ok4uw	5653	30	1	1	CD
cord-001835-0s7ok4uw	5653	31	,	,	,
cord-001835-0s7ok4uw	5653	32	Cris	Cris	NNP
cord-001835-0s7ok4uw	5653	33	Lapthorn	Lapthorn	NNP
cord-001835-0s7ok4uw	5653	34	1	1	CD
cord-001835-0s7ok4uw	5653	35	,	,	,
cord-001835-0s7ok4uw	5653	36	Fernando	Fernando	NNP
cord-001835-0s7ok4uw	5653	37	Naclario	Naclario	NNP
cord-001835-0s7ok4uw	5653	38	2	2	CD
cord-001835-0s7ok4uw	5653	39	1	1	CD
cord-001835-0s7ok4uw	5653	40	University	University	NNP
cord-001835-0s7ok4uw	5653	41	of	of	IN
cord-001835-0s7ok4uw	5653	42	Greenwich	Greenwich	NNP
cord-001835-0s7ok4uw	5653	43	(	(	-LRB-
cord-001835-0s7ok4uw	5653	44	Faculty	Faculty	NNP
cord-001835-0s7ok4uw	5653	45	of	of	IN
cord-001835-0s7ok4uw	5653	46	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	5653	47	and	and	CC
cord-001835-0s7ok4uw	5653	48	Sciene	Sciene	NNP
cord-001835-0s7ok4uw	5653	49	)	)	-RRB-
cord-001835-0s7ok4uw	5653	50	,	,	,
cord-001835-0s7ok4uw	5653	51	2	2	CD
cord-001835-0s7ok4uw	5653	52	University	University	NNP
cord-001835-0s7ok4uw	5653	53	of	of	IN
cord-001835-0s7ok4uw	5653	54	Greenwich	Greenwich	NNP
cord-001835-0s7ok4uw	5653	55	(	(	-LRB-
cord-001835-0s7ok4uw	5653	56	Centre	Centre	NNP
cord-001835-0s7ok4uw	5653	57	of	of	IN
cord-001835-0s7ok4uw	5653	58	Sports	Sports	NNPS
cord-001835-0s7ok4uw	5653	59	Science	Science	NNP
cord-001835-0s7ok4uw	5653	60	and	and	CC
cord-001835-0s7ok4uw	5653	61	Human	Human	NNP
cord-001835-0s7ok4uw	5653	62	Performance	Performance	NNP
cord-001835-0s7ok4uw	5653	63	)	)	-RRB-
cord-001835-0s7ok4uw	5654	1	Numerous	numerous	JJ
cord-001835-0s7ok4uw	5654	2	studies	study	NNS
cord-001835-0s7ok4uw	5654	3	have	have	VBP
cord-001835-0s7ok4uw	5654	4	investigated	investigate	VBN
cord-001835-0s7ok4uw	5654	5	the	the	DT
cord-001835-0s7ok4uw	5654	6	effect	effect	NN
cord-001835-0s7ok4uw	5654	7	of	of	IN
cord-001835-0s7ok4uw	5654	8	exercise	exercise	NN
cord-001835-0s7ok4uw	5654	9	on	on	IN
cord-001835-0s7ok4uw	5654	10	mucosal	mucosal	JJ
cord-001835-0s7ok4uw	5654	11	immunity	immunity	NN
cord-001835-0s7ok4uw	5654	12	but	but	CC
cord-001835-0s7ok4uw	5654	13	the	the	DT
cord-001835-0s7ok4uw	5654	14	focus	focus	NN
cord-001835-0s7ok4uw	5654	15	has	have	VBZ
cord-001835-0s7ok4uw	5654	16	mainly	mainly	RB
cord-001835-0s7ok4uw	5654	17	been	be	VBN
cord-001835-0s7ok4uw	5654	18	on	on	IN
cord-001835-0s7ok4uw	5654	19	salivary	salivary	JJ
cord-001835-0s7ok4uw	5654	20	immunoglobulins	immunoglobulin	NNS
cord-001835-0s7ok4uw	5654	21	lysozymes	lysozyme	NNS
cord-001835-0s7ok4uw	5654	22	and	and	CC
cord-001835-0s7ok4uw	5654	23	hormones	hormone	NNS
cord-001835-0s7ok4uw	5654	24	(	(	-LRB-
cord-001835-0s7ok4uw	5654	25	cortisol	cortisol	NN
cord-001835-0s7ok4uw	5654	26	,	,	,
cord-001835-0s7ok4uw	5654	27	testosterone	testosterone	NN
cord-001835-0s7ok4uw	5654	28	)	)	-RRB-
cord-001835-0s7ok4uw	5654	29	.	.	.
cord-001835-0s7ok4uw	5655	1	This	this	DT
cord-001835-0s7ok4uw	5655	2	is	be	VBZ
cord-001835-0s7ok4uw	5655	3	not	not	RB
cord-001835-0s7ok4uw	5655	4	surprising	surprising	JJ
cord-001835-0s7ok4uw	5655	5	given	give	VBN
cord-001835-0s7ok4uw	5655	6	that	that	IN
cord-001835-0s7ok4uw	5655	7	IgA	IgA	NNP
cord-001835-0s7ok4uw	5655	8	and	and	CC
cord-001835-0s7ok4uw	5655	9	IgG	IgG	NNP
cord-001835-0s7ok4uw	5655	10	are	be	VBP
cord-001835-0s7ok4uw	5655	11	the	the	DT
cord-001835-0s7ok4uw	5655	12	predominant	predominant	JJ
cord-001835-0s7ok4uw	5655	13	immunoglobulins	immunoglobulin	NNS
cord-001835-0s7ok4uw	5655	14	in	in	IN
cord-001835-0s7ok4uw	5655	15	saliva	saliva	NN
cord-001835-0s7ok4uw	5655	16	and	and	CC
cord-001835-0s7ok4uw	5655	17	there	there	EX
cord-001835-0s7ok4uw	5655	18	is	be	VBZ
cord-001835-0s7ok4uw	5655	19	a	a	DT
cord-001835-0s7ok4uw	5655	20	relationship	relationship	NN
cord-001835-0s7ok4uw	5655	21	between	between	IN
cord-001835-0s7ok4uw	5655	22	mucosal	mucosal	JJ
cord-001835-0s7ok4uw	5655	23	immunity	immunity	NN
cord-001835-0s7ok4uw	5655	24	and	and	CC
cord-001835-0s7ok4uw	5655	25	upper	upper	JJ
cord-001835-0s7ok4uw	5655	26	respiratory	respiratory	JJ
cord-001835-0s7ok4uw	5655	27	illness	illness	NN
cord-001835-0s7ok4uw	5655	28	.	.	.
cord-001835-0s7ok4uw	5656	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5656	2	is	be	VBZ
cord-001835-0s7ok4uw	5656	3	well	well	RB
cord-001835-0s7ok4uw	5656	4	known	know	VBN
cord-001835-0s7ok4uw	5656	5	that	that	IN
cord-001835-0s7ok4uw	5656	6	physical	physical	JJ
cord-001835-0s7ok4uw	5656	7	and	and	CC
cord-001835-0s7ok4uw	5656	8	mental	mental	JJ
cord-001835-0s7ok4uw	5656	9	stress	stress	NN
cord-001835-0s7ok4uw	5656	10	provoke	provoke	VBP
cord-001835-0s7ok4uw	5656	11	the	the	DT
cord-001835-0s7ok4uw	5656	12	release	release	NN
cord-001835-0s7ok4uw	5656	13	of	of	IN
cord-001835-0s7ok4uw	5656	14	cortisol	cortisol	NN
cord-001835-0s7ok4uw	5656	15	from	from	IN
cord-001835-0s7ok4uw	5656	16	hypothalamic	hypothalamic	JJ
cord-001835-0s7ok4uw	5656	17	pituitary	pituitary	JJ
cord-001835-0s7ok4uw	5656	18	adrenal	adrenal	JJ
cord-001835-0s7ok4uw	5656	19	axis	axis	NN
cord-001835-0s7ok4uw	5656	20	,	,	,
cord-001835-0s7ok4uw	5656	21	by	by	IN
cord-001835-0s7ok4uw	5656	22	which	which	WDT
cord-001835-0s7ok4uw	5656	23	stress	stress	NN
cord-001835-0s7ok4uw	5656	24	can	can	MD
cord-001835-0s7ok4uw	5656	25	modulate	modulate	VB
cord-001835-0s7ok4uw	5656	26	various	various	JJ
cord-001835-0s7ok4uw	5656	27	immune	immune	JJ
cord-001835-0s7ok4uw	5656	28	responses	response	NNS
cord-001835-0s7ok4uw	5656	29	.	.	.
cord-001835-0s7ok4uw	5657	1	In	in	IN
cord-001835-0s7ok4uw	5657	2	general	general	JJ
cord-001835-0s7ok4uw	5657	3	,	,	,
cord-001835-0s7ok4uw	5657	4	cortisol	cortisol	NN
cord-001835-0s7ok4uw	5657	5	and	and	CC
cord-001835-0s7ok4uw	5657	6	growth	growth	NN
cord-001835-0s7ok4uw	5657	7	hormones	hormone	NNS
cord-001835-0s7ok4uw	5657	8	helps	help	VBZ
cord-001835-0s7ok4uw	5657	9	to	to	TO
cord-001835-0s7ok4uw	5657	10	induce	induce	VB
cord-001835-0s7ok4uw	5657	11	the	the	DT
cord-001835-0s7ok4uw	5657	12	activation	activation	NN
cord-001835-0s7ok4uw	5657	13	of	of	IN
cord-001835-0s7ok4uw	5657	14	neutrophils	neutrophil	NNS
cord-001835-0s7ok4uw	5657	15	.	.	.
cord-001835-0s7ok4uw	5658	1	To	to	IN
cord-001835-0s7ok4uw	5658	2	date	date	NN
cord-001835-0s7ok4uw	5658	3	,	,	,
cord-001835-0s7ok4uw	5658	4	this	this	DT
cord-001835-0s7ok4uw	5658	5	study	study	NN
cord-001835-0s7ok4uw	5658	6	represents	represent	VBZ
cord-001835-0s7ok4uw	5658	7	the	the	DT
cord-001835-0s7ok4uw	5658	8	first	first	JJ
cord-001835-0s7ok4uw	5658	9	study	study	NN
cord-001835-0s7ok4uw	5658	10	that	that	WDT
cord-001835-0s7ok4uw	5658	11	investigated	investigate	VBD
cord-001835-0s7ok4uw	5658	12	the	the	DT
cord-001835-0s7ok4uw	5658	13	correlation	correlation	NN
cord-001835-0s7ok4uw	5658	14	between	between	IN
cord-001835-0s7ok4uw	5658	15	human	human	JJ
cord-001835-0s7ok4uw	5658	16	neutrophil	neutrophil	NN
cord-001835-0s7ok4uw	5658	17	alpha	alpha	NN
cord-001835-0s7ok4uw	5658	18	defensins	defensins	NNP
cord-001835-0s7ok4uw	5658	19	family	family	NN
cord-001835-0s7ok4uw	5658	20	against	against	IN
cord-001835-0s7ok4uw	5658	21	cortisol	cortisol	NNP
cord-001835-0s7ok4uw	5658	22	(	(	-LRB-
cord-001835-0s7ok4uw	5658	23	stress	stress	NN
cord-001835-0s7ok4uw	5658	24	hormone	hormone	NN
cord-001835-0s7ok4uw	5658	25	)	)	-RRB-
cord-001835-0s7ok4uw	5658	26	and	and	CC
cord-001835-0s7ok4uw	5658	27	testosterone	testosterone	NN
cord-001835-0s7ok4uw	5658	28	(	(	-LRB-
cord-001835-0s7ok4uw	5658	29	growth	growth	NN
cord-001835-0s7ok4uw	5658	30	hormone	hormone	NN
cord-001835-0s7ok4uw	5658	31	)	)	-RRB-
cord-001835-0s7ok4uw	5658	32	in	in	IN
cord-001835-0s7ok4uw	5658	33	human	human	JJ
cord-001835-0s7ok4uw	5658	34	saliva	saliva	NN
cord-001835-0s7ok4uw	5658	35	before	before	RB
cord-001835-0s7ok4uw	5658	36	and	and	CC
cord-001835-0s7ok4uw	5658	37	after	after	IN
cord-001835-0s7ok4uw	5658	38	exercise	exercise	NN
cord-001835-0s7ok4uw	5658	39	or	or	CC
cord-001835-0s7ok4uw	5658	40	training	training	NN
cord-001835-0s7ok4uw	5658	41	.	.	.
cord-001835-0s7ok4uw	5659	1	Twelve	twelve	CD
cord-001835-0s7ok4uw	5659	2	resistance	resistance	NN
cord-001835-0s7ok4uw	5659	3	trained	train	VBN
cord-001835-0s7ok4uw	5659	4	athletes	athlete	NNS
cord-001835-0s7ok4uw	5659	5	volunteered	volunteer	VBD
cord-001835-0s7ok4uw	5659	6	to	to	TO
cord-001835-0s7ok4uw	5659	7	participate	participate	VB
cord-001835-0s7ok4uw	5659	8	in	in	IN
cord-001835-0s7ok4uw	5659	9	the	the	DT
cord-001835-0s7ok4uw	5659	10	study	study	NN
cord-001835-0s7ok4uw	5659	11	.	.	.
cord-001835-0s7ok4uw	5660	1	Participants	participant	NNS
cord-001835-0s7ok4uw	5660	2	consumed	consume	VBD
cord-001835-0s7ok4uw	5660	3	supplements	supplement	NNS
cord-001835-0s7ok4uw	5660	4	during	during	IN
cord-001835-0s7ok4uw	5660	5	exercise	exercise	NN
cord-001835-0s7ok4uw	5660	6	and	and	CC
cord-001835-0s7ok4uw	5660	7	the	the	DT
cord-001835-0s7ok4uw	5660	8	HNP	HNP	NNP
cord-001835-0s7ok4uw	5660	9	1	1	CD
cord-001835-0s7ok4uw	5660	10	-	-	SYM
cord-001835-0s7ok4uw	5660	11	3	3	CD
cord-001835-0s7ok4uw	5660	12	,	,	,
cord-001835-0s7ok4uw	5660	13	cortisol	cortisol	NN
cord-001835-0s7ok4uw	5660	14	and	and	CC
cord-001835-0s7ok4uw	5660	15	testosterone	testosterone	NN
cord-001835-0s7ok4uw	5660	16	response	response	NN
cord-001835-0s7ok4uw	5660	17	was	be	VBD
cord-001835-0s7ok4uw	5660	18	investigated	investigate	VBN
cord-001835-0s7ok4uw	5660	19	pre	pre	JJ
cord-001835-0s7ok4uw	5660	20	,	,	,
cord-001835-0s7ok4uw	5660	21	post	post	NNP
cord-001835-0s7ok4uw	5660	22	30	30	CD
cord-001835-0s7ok4uw	5660	23	and	and	CC
cord-001835-0s7ok4uw	5660	24	60	60	CD
cord-001835-0s7ok4uw	5660	25	minutes	minute	NNS
cord-001835-0s7ok4uw	5660	26	of	of	IN
cord-001835-0s7ok4uw	5660	27	the	the	DT
cord-001835-0s7ok4uw	5660	28	workout	workout	NN
cord-001835-0s7ok4uw	5660	29	.	.	.
cord-001835-0s7ok4uw	5661	1	The	the	DT
cord-001835-0s7ok4uw	5661	2	correlation	correlation	NN
cord-001835-0s7ok4uw	5661	3	between	between	IN
cord-001835-0s7ok4uw	5661	4	salivary	salivary	NN
cord-001835-0s7ok4uw	5661	5	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5661	6	peptide	peptide	NN
cord-001835-0s7ok4uw	5661	7	(	(	-LRB-
cord-001835-0s7ok4uw	5661	8	HNP	HNP	NNP
cord-001835-0s7ok4uw	5661	9	1	1	CD
cord-001835-0s7ok4uw	5661	10	-	-	SYM
cord-001835-0s7ok4uw	5661	11	3	3	CD
cord-001835-0s7ok4uw	5661	12	)	)	-RRB-
cord-001835-0s7ok4uw	5661	13	and	and	CC
cord-001835-0s7ok4uw	5661	14	stress	stress	NN
cord-001835-0s7ok4uw	5661	15	hormone	hormone	NN
cord-001835-0s7ok4uw	5661	16	(	(	-LRB-
cord-001835-0s7ok4uw	5661	17	cortisol	cortisol	NN
cord-001835-0s7ok4uw	5661	18	and	and	CC
cord-001835-0s7ok4uw	5661	19	testosterone	testosterone	NN
cord-001835-0s7ok4uw	5661	20	)	)	-RRB-
cord-001835-0s7ok4uw	5661	21	has	have	VBZ
cord-001835-0s7ok4uw	5661	22	been	be	VBN
cord-001835-0s7ok4uw	5661	23	investigated	investigate	VBN
cord-001835-0s7ok4uw	5661	24	using	use	VBG
cord-001835-0s7ok4uw	5661	25	ELISA	ELISA	NNP
cord-001835-0s7ok4uw	5661	26	.	.	.
cord-001835-0s7ok4uw	5662	1	Cortisol	cortisol	NN
cord-001835-0s7ok4uw	5662	2	showed	show	VBD
cord-001835-0s7ok4uw	5662	3	no	no	DT
cord-001835-0s7ok4uw	5662	4	significant	significant	JJ
cord-001835-0s7ok4uw	5662	5	(	(	-LRB-
cord-001835-0s7ok4uw	5662	6	p	p	NN
cord-001835-0s7ok4uw	5662	7	5	5	CD
cord-001835-0s7ok4uw	5662	8	0.818	0.818	CD
cord-001835-0s7ok4uw	5662	9	)	)	-RRB-
cord-001835-0s7ok4uw	5662	10	difference	difference	NN
cord-001835-0s7ok4uw	5662	11	for	for	IN
cord-001835-0s7ok4uw	5662	12	(	(	-LRB-
cord-001835-0s7ok4uw	5662	13	pre	pre	VB
cord-001835-0s7ok4uw	5662	14	to	to	IN
cord-001835-0s7ok4uw	5662	15	30	30	CD
cord-001835-0s7ok4uw	5662	16	min	min	NN
cord-001835-0s7ok4uw	5662	17	post	post	NN
cord-001835-0s7ok4uw	5662	18	)	)	-RRB-
cord-001835-0s7ok4uw	5662	19	between	between	IN
cord-001835-0s7ok4uw	5662	20	CHO	CHO	NNP
cord-001835-0s7ok4uw	5662	21	and	and	CC
cord-001835-0s7ok4uw	5662	22	PL	PL	NNP
cord-001835-0s7ok4uw	5662	23	(	(	-LRB-
cord-001835-0s7ok4uw	5662	24	CHO	CHO	NNP
cord-001835-0s7ok4uw	5662	25	:	:	:
cord-001835-0s7ok4uw	5662	26	483.07	483.07	CD
cord-001835-0s7ok4uw	5662	27	6	6	CD
cord-001835-0s7ok4uw	5662	28	912.77	912.77	CD
cord-001835-0s7ok4uw	5662	29	ng	ng	NN
cord-001835-0s7ok4uw	5662	30	/	/	SYM
cord-001835-0s7ok4uw	5662	31	mL	mL	NNP
cord-001835-0s7ok4uw	5662	32	;	;	:
cord-001835-0s7ok4uw	5662	33	PL5	pl5	JJ
cord-001835-0s7ok4uw	5662	34	583.82	583.82	CD
cord-001835-0s7ok4uw	5662	35	6	6	CD
cord-001835-0s7ok4uw	5663	1	1134.33	1134.33	CD
cord-001835-0s7ok4uw	5663	2	ng	ng	NNP
cord-001835-0s7ok4uw	5663	3	/	/	SYM
cord-001835-0s7ok4uw	5663	4	mL	ml	NN
cord-001835-0s7ok4uw	5663	5	)	)	-RRB-
cord-001835-0s7ok4uw	5663	6	conditions	condition	NNS
cord-001835-0s7ok4uw	5663	7	but	but	CC
cord-001835-0s7ok4uw	5663	8	a	a	DT
cord-001835-0s7ok4uw	5663	9	strong	strong	JJ
cord-001835-0s7ok4uw	5663	10	trend	trend	NN
cord-001835-0s7ok4uw	5663	11	(	(	-LRB-
cord-001835-0s7ok4uw	5663	12	p	p	NN
cord-001835-0s7ok4uw	5663	13	5	5	CD
cord-001835-0s7ok4uw	5663	14	0.074	0.074	CD
cord-001835-0s7ok4uw	5663	15	)	)	-RRB-
cord-001835-0s7ok4uw	5663	16	was	be	VBD
cord-001835-0s7ok4uw	5663	17	observed	observe	VBN
cord-001835-0s7ok4uw	5663	18	for	for	IN
cord-001835-0s7ok4uw	5663	19	(	(	-LRB-
cord-001835-0s7ok4uw	5663	20	pre	pre	VB
cord-001835-0s7ok4uw	5663	21	to	to	IN
cord-001835-0s7ok4uw	5663	22	60	60	CD
cord-001835-0s7ok4uw	5663	23	min	min	NN
cord-001835-0s7ok4uw	5663	24	post	post	NN
cord-001835-0s7ok4uw	5663	25	)	)	-RRB-
cord-001835-0s7ok4uw	5663	26	post	post	JJ
cord-001835-0s7ok4uw	5663	27	(	(	-LRB-
cord-001835-0s7ok4uw	5663	28	CHO	CHO	NNP
cord-001835-0s7ok4uw	5663	29	:	:	:
cord-001835-0s7ok4uw	5663	30	1023.19	1023.19	CD
cord-001835-0s7ok4uw	5663	31	6	6	CD
cord-001835-0s7ok4uw	5663	32	1500.40	1500.40	CD
cord-001835-0s7ok4uw	5663	33	ng	ng	NNP
cord-001835-0s7ok4uw	5663	34	/	/	SYM
cord-001835-0s7ok4uw	5663	35	mL	mL	NNP
cord-001835-0s7ok4uw	5663	36	;	;	:
cord-001835-0s7ok4uw	5663	37	PL5	PL5	NNP
cord-001835-0s7ok4uw	5663	38	1480.33	1480.33	CD
cord-001835-0s7ok4uw	5663	39	6	6	CD
cord-001835-0s7ok4uw	5663	40	2214.80	2214.80	CD
cord-001835-0s7ok4uw	5663	41	ng	ng	NN
cord-001835-0s7ok4uw	5663	42	/	/	SYM
cord-001835-0s7ok4uw	5663	43	mL	ml	NN
cord-001835-0s7ok4uw	5663	44	)	)	-RRB-
cord-001835-0s7ok4uw	5663	45	condition	condition	NN
cord-001835-0s7ok4uw	5663	46	.	.	.
cord-001835-0s7ok4uw	5664	1	Testosterone	testosterone	NN
cord-001835-0s7ok4uw	5664	2	showed	show	VBD
cord-001835-0s7ok4uw	5664	3	no	no	DT
cord-001835-0s7ok4uw	5664	4	significant	significant	JJ
cord-001835-0s7ok4uw	5664	5	(	(	-LRB-
cord-001835-0s7ok4uw	5664	6	p	p	NN
cord-001835-0s7ok4uw	5664	7	5	5	CD
cord-001835-0s7ok4uw	5664	8	0.167	0.167	CD
cord-001835-0s7ok4uw	5664	9	;	;	:
cord-001835-0s7ok4uw	5664	10	p	p	NN
cord-001835-0s7ok4uw	5664	11	5	5	CD
cord-001835-0s7ok4uw	5664	12	0.156	0.156	CD
cord-001835-0s7ok4uw	5664	13	)	)	-RRB-
cord-001835-0s7ok4uw	5664	14	difference	difference	NN
cord-001835-0s7ok4uw	5664	15	for	for	IN
cord-001835-0s7ok4uw	5664	16	(	(	-LRB-
cord-001835-0s7ok4uw	5664	17	pre	pre	VB
cord-001835-0s7ok4uw	5664	18	to	to	IN
cord-001835-0s7ok4uw	5664	19	30	30	CD
cord-001835-0s7ok4uw	5664	20	min	min	NN
cord-001835-0s7ok4uw	5664	21	post	post	NN
cord-001835-0s7ok4uw	5664	22	)	)	-RRB-
cord-001835-0s7ok4uw	5664	23	between	between	IN
cord-001835-0s7ok4uw	5664	24	CHO	CHO	NNP
cord-001835-0s7ok4uw	5664	25	and	and	CC
cord-001835-0s7ok4uw	5664	26	PL	PL	NNP
cord-001835-0s7ok4uw	5664	27	(	(	-LRB-
cord-001835-0s7ok4uw	5664	28	CHO	CHO	NNP
cord-001835-0s7ok4uw	5664	29	:	:	:
cord-001835-0s7ok4uw	5664	30	23.32	23.32	CD
cord-001835-0s7ok4uw	5664	31	6	6	CD
cord-001835-0s7ok4uw	5664	32	44.11	44.11	CD
cord-001835-0s7ok4uw	5664	33	ng	ng	NN
cord-001835-0s7ok4uw	5664	34	/	/	SYM
cord-001835-0s7ok4uw	5664	35	mL	mL	NNP
cord-001835-0s7ok4uw	5664	36	;	;	:
cord-001835-0s7ok4uw	5664	37	PL5	PL5	NNP
cord-001835-0s7ok4uw	5664	38	10.40	10.40	CD
cord-001835-0s7ok4uw	5664	39	6	6	CD
cord-001835-0s7ok4uw	5664	40	14.19	14.19	CD
cord-001835-0s7ok4uw	5664	41	ng	ng	NN
cord-001835-0s7ok4uw	5664	42	/	/	SYM
cord-001835-0s7ok4uw	5664	43	mL	mL	NNP
cord-001835-0s7ok4uw	5664	44	)	)	-RRB-
cord-001835-0s7ok4uw	5664	45	and	and	CC
cord-001835-0s7ok4uw	5664	46	for	for	IN
cord-001835-0s7ok4uw	5664	47	(	(	-LRB-
cord-001835-0s7ok4uw	5664	48	pre	pre	VB
cord-001835-0s7ok4uw	5664	49	to	to	IN
cord-001835-0s7ok4uw	5664	50	60	60	CD
cord-001835-0s7ok4uw	5664	51	min	min	NN
cord-001835-0s7ok4uw	5664	52	post	post	NN
cord-001835-0s7ok4uw	5664	53	)	)	-RRB-
cord-001835-0s7ok4uw	5664	54	post	post	NN
cord-001835-0s7ok4uw	5665	1	(	(	-LRB-
cord-001835-0s7ok4uw	5665	2	CHO	CHO	NNP
cord-001835-0s7ok4uw	5665	3	:	:	:
cord-001835-0s7ok4uw	5665	4	26.42	26.42	CD
cord-001835-0s7ok4uw	5665	5	6	6	CD
cord-001835-0s7ok4uw	5665	6	19.11	19.11	CD
cord-001835-0s7ok4uw	5665	7	ng	ng	NN
cord-001835-0s7ok4uw	5665	8	/	/	SYM
cord-001835-0s7ok4uw	5665	9	mL	mL	NNP
cord-001835-0s7ok4uw	5665	10	;	;	:
cord-001835-0s7ok4uw	5665	11	PL5	PL5	NNP
cord-001835-0s7ok4uw	5665	12	23.72	23.72	CD
cord-001835-0s7ok4uw	5665	13	6	6	CD
cord-001835-0s7ok4uw	5665	14	17.91	17.91	CD
cord-001835-0s7ok4uw	5665	15	ng	ng	NN
cord-001835-0s7ok4uw	5665	16	/	/	SYM
cord-001835-0s7ok4uw	5665	17	mL	ml	NN
cord-001835-0s7ok4uw	5665	18	)	)	-RRB-
cord-001835-0s7ok4uw	5665	19	condition	condition	NN
cord-001835-0s7ok4uw	5665	20	.	.	.
cord-001835-0s7ok4uw	5666	1	HNP	HNP	NNP
cord-001835-0s7ok4uw	5666	2	1	1	CD
cord-001835-0s7ok4uw	5666	3	-	-	SYM
cord-001835-0s7ok4uw	5666	4	3	3	CD
cord-001835-0s7ok4uw	5666	5	showed	show	VBD
cord-001835-0s7ok4uw	5666	6	no	no	DT
cord-001835-0s7ok4uw	5666	7	significant	significant	JJ
cord-001835-0s7ok4uw	5666	8	(	(	-LRB-
cord-001835-0s7ok4uw	5666	9	p	p	NN
cord-001835-0s7ok4uw	5666	10	5	5	CD
cord-001835-0s7ok4uw	5666	11	0.348	0.348	CD
cord-001835-0s7ok4uw	5666	12	)	)	-RRB-
cord-001835-0s7ok4uw	5666	13	difference	difference	NN
cord-001835-0s7ok4uw	5666	14	for	for	IN
cord-001835-0s7ok4uw	5666	15	(	(	-LRB-
cord-001835-0s7ok4uw	5666	16	pre	pre	VB
cord-001835-0s7ok4uw	5666	17	to	to	IN
cord-001835-0s7ok4uw	5666	18	30	30	CD
cord-001835-0s7ok4uw	5666	19	min	min	NN
cord-001835-0s7ok4uw	5666	20	post	post	NN
cord-001835-0s7ok4uw	5666	21	)	)	-RRB-
cord-001835-0s7ok4uw	5666	22	between	between	IN
cord-001835-0s7ok4uw	5666	23	CHO	CHO	NNP
cord-001835-0s7ok4uw	5666	24	and	and	CC
cord-001835-0s7ok4uw	5666	25	PL	PL	NNP
cord-001835-0s7ok4uw	5666	26	(	(	-LRB-
cord-001835-0s7ok4uw	5666	27	CHO	CHO	NNP
cord-001835-0s7ok4uw	5666	28	:	:	:
cord-001835-0s7ok4uw	5667	1	72.26	72.26	CD
cord-001835-0s7ok4uw	5667	2	6	6	CD
cord-001835-0s7ok4uw	5667	3	148.82	148.82	CD
cord-001835-0s7ok4uw	5667	4	;	;	:
cord-001835-0s7ok4uw	5667	5	PL5	PL5	NNP
cord-001835-0s7ok4uw	5667	6	125.20	125.20	CD
cord-001835-0s7ok4uw	5667	7	6	6	CD
cord-001835-0s7ok4uw	5667	8	70.00	70.00	CD
cord-001835-0s7ok4uw	5667	9	)	)	-RRB-
cord-001835-0s7ok4uw	5667	10	conditions	condition	NNS
cord-001835-0s7ok4uw	5667	11	but	but	CC
cord-001835-0s7ok4uw	5667	12	significant	significant	JJ
cord-001835-0s7ok4uw	5667	13	difference	difference	NN
cord-001835-0s7ok4uw	5668	1	(	(	-LRB-
cord-001835-0s7ok4uw	5668	2	p	p	NN
cord-001835-0s7ok4uw	5668	3	5	5	CD
cord-001835-0s7ok4uw	5668	4	0.026	0.026	CD
cord-001835-0s7ok4uw	5668	5	)	)	-RRB-
cord-001835-0s7ok4uw	5668	6	was	be	VBD
cord-001835-0s7ok4uw	5668	7	observed	observe	VBN
cord-001835-0s7ok4uw	5668	8	for	for	IN
cord-001835-0s7ok4uw	5668	9	(	(	-LRB-
cord-001835-0s7ok4uw	5668	10	pre	pre	VB
cord-001835-0s7ok4uw	5668	11	to	to	IN
cord-001835-0s7ok4uw	5668	12	60	60	CD
cord-001835-0s7ok4uw	5668	13	min	min	NN
cord-001835-0s7ok4uw	5668	14	post	post	NN
cord-001835-0s7ok4uw	5668	15	)	)	-RRB-
cord-001835-0s7ok4uw	5668	16	between	between	IN
cord-001835-0s7ok4uw	5668	17	CHO	CHO	NNP
cord-001835-0s7ok4uw	5668	18	and	and	CC
cord-001835-0s7ok4uw	5668	19	PL	PL	NNP
cord-001835-0s7ok4uw	5668	20	(	(	-LRB-
cord-001835-0s7ok4uw	5668	21	CHO	CHO	NNP
cord-001835-0s7ok4uw	5668	22	:	:	:
cord-001835-0s7ok4uw	5668	23	35.18	35.18	CD
cord-001835-0s7ok4uw	5668	24	6	6	CD
cord-001835-0s7ok4uw	5668	25	182.69	182.69	CD
cord-001835-0s7ok4uw	5668	26	;	;	:
cord-001835-0s7ok4uw	5668	27	PL5	PL5	NNP
cord-001835-0s7ok4uw	5668	28	228.74	228.74	CD
cord-001835-0s7ok4uw	5668	29	6	6	CD
cord-001835-0s7ok4uw	5668	30	151.63	151.63	CD
cord-001835-0s7ok4uw	5668	31	)	)	-RRB-
cord-001835-0s7ok4uw	5668	32	condition	condition	NN
cord-001835-0s7ok4uw	5668	33	.	.	.
cord-001835-0s7ok4uw	5669	1	The	the	DT
cord-001835-0s7ok4uw	5669	2	present	present	JJ
cord-001835-0s7ok4uw	5669	3	findings	finding	NNS
cord-001835-0s7ok4uw	5669	4	suggested	suggest	VBD
cord-001835-0s7ok4uw	5669	5	that	that	IN
cord-001835-0s7ok4uw	5669	6	there	there	EX
cord-001835-0s7ok4uw	5669	7	is	be	VBZ
cord-001835-0s7ok4uw	5669	8	no	no	DT
cord-001835-0s7ok4uw	5669	9	correlation	correlation	NN
cord-001835-0s7ok4uw	5669	10	between	between	IN
cord-001835-0s7ok4uw	5669	11	salivary	salivary	NN
cord-001835-0s7ok4uw	5669	12	HNP	HNP	NNP
cord-001835-0s7ok4uw	5669	13	1	1	CD
cord-001835-0s7ok4uw	5669	14	-	-	SYM
cord-001835-0s7ok4uw	5669	15	3	3	CD
cord-001835-0s7ok4uw	5669	16	and	and	CC
cord-001835-0s7ok4uw	5669	17	cortisol	cortisol	NN
cord-001835-0s7ok4uw	5669	18	for	for	IN
cord-001835-0s7ok4uw	5669	19	(	(	-LRB-
cord-001835-0s7ok4uw	5669	20	PL	pl	NN
cord-001835-0s7ok4uw	5669	21	:	:	:
cord-001835-0s7ok4uw	5669	22	R2	r2	NN
cord-001835-0s7ok4uw	5669	23	5	5	CD
cord-001835-0s7ok4uw	5669	24	0.02	0.02	CD
cord-001835-0s7ok4uw	5669	25	and	and	CC
cord-001835-0s7ok4uw	5669	26	CHO	CHO	NNP
cord-001835-0s7ok4uw	5669	27	:	:	:
cord-001835-0s7ok4uw	5669	28	R2	R2	NNP
cord-001835-0s7ok4uw	5669	29	5	5	CD
cord-001835-0s7ok4uw	5669	30	0.01	0.01	CD
cord-001835-0s7ok4uw	5669	31	)	)	-RRB-
cord-001835-0s7ok4uw	5669	32	;	;	:
cord-001835-0s7ok4uw	5669	33	HNP	HNP	NNP
cord-001835-0s7ok4uw	5669	34	1	1	CD
cord-001835-0s7ok4uw	5669	35	-	-	SYM
cord-001835-0s7ok4uw	5669	36	3	3	CD
cord-001835-0s7ok4uw	5669	37	and	and	CC
cord-001835-0s7ok4uw	5669	38	testosterone	testosterone	NN
cord-001835-0s7ok4uw	5669	39	(	(	-LRB-
cord-001835-0s7ok4uw	5669	40	PL	pl	NN
cord-001835-0s7ok4uw	5669	41	:	:	:
cord-001835-0s7ok4uw	5669	42	R2	r2	NN
cord-001835-0s7ok4uw	5669	43	5	5	CD
cord-001835-0s7ok4uw	5669	44	0.20	0.20	CD
cord-001835-0s7ok4uw	5669	45	and	and	CC
cord-001835-0s7ok4uw	5669	46	CHO	CHO	NNP
cord-001835-0s7ok4uw	5669	47	:	:	:
cord-001835-0s7ok4uw	5669	48	R2	R2	NNP
cord-001835-0s7ok4uw	5669	49	5	5	CD
cord-001835-0s7ok4uw	5669	50	0.10	0.10	CD
cord-001835-0s7ok4uw	5669	51	)	)	-RRB-
cord-001835-0s7ok4uw	5669	52	.	.	.
cord-001835-0s7ok4uw	5670	1	A	a	DT
cord-001835-0s7ok4uw	5670	2	worth	worth	JJ
cord-001835-0s7ok4uw	5670	3	note	note	NN
cord-001835-0s7ok4uw	5670	4	from	from	IN
cord-001835-0s7ok4uw	5670	5	previous	previous	JJ
cord-001835-0s7ok4uw	5670	6	study	study	NN
cord-001835-0s7ok4uw	5670	7	which	which	WDT
cord-001835-0s7ok4uw	5670	8	suggested	suggest	VBD
cord-001835-0s7ok4uw	5670	9	that	that	IN
cord-001835-0s7ok4uw	5670	10	using	use	VBG
cord-001835-0s7ok4uw	5670	11	murine	murine	JJ
cord-001835-0s7ok4uw	5670	12	skin	skin	NN
cord-001835-0s7ok4uw	5670	13	model	model	NN
cord-001835-0s7ok4uw	5670	14	(	(	-LRB-
cord-001835-0s7ok4uw	5670	15	an	an	DT
cord-001835-0s7ok4uw	5670	16	increase	increase	NN
cord-001835-0s7ok4uw	5670	17	in	in	IN
cord-001835-0s7ok4uw	5670	18	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	5670	19	glucorticoids	glucorticoid	NNS
cord-001835-0s7ok4uw	5670	20	(	(	-LRB-
cord-001835-0s7ok4uw	5670	21	cortisol	cortisol	NN
cord-001835-0s7ok4uw	5670	22	)	)	-RRB-
cord-001835-0s7ok4uw	5670	23	by	by	IN
cord-001835-0s7ok4uw	5670	24	physiological	physiological	JJ
cord-001835-0s7ok4uw	5670	25	stress	stress	NN
cord-001835-0s7ok4uw	5670	26	reduced	reduce	VBN
cord-001835-0s7ok4uw	5670	27	mRNA	mrna	NN
cord-001835-0s7ok4uw	5670	28	levels	level	NNS
cord-001835-0s7ok4uw	5670	29	of	of	IN
cord-001835-0s7ok4uw	5670	30	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5670	31	peptide	peptide	NN
cord-001835-0s7ok4uw	5670	32	(	(	-LRB-
cord-001835-0s7ok4uw	5670	33	cathelicidin	cathelicidin	NNP
cord-001835-0s7ok4uw	5670	34	)	)	-RRB-
cord-001835-0s7ok4uw	5670	35	.	.	.
cord-001835-0s7ok4uw	5671	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5671	2	is	be	VBZ
cord-001835-0s7ok4uw	5671	3	not	not	RB
cord-001835-0s7ok4uw	5671	4	clear	clear	JJ
cord-001835-0s7ok4uw	5671	5	that	that	IN
cord-001835-0s7ok4uw	5671	6	the	the	DT
cord-001835-0s7ok4uw	5671	7	correlation	correlation	NN
cord-001835-0s7ok4uw	5671	8	between	between	IN
cord-001835-0s7ok4uw	5671	9	hormones	hormone	NNS
cord-001835-0s7ok4uw	5671	10	and	and	CC
cord-001835-0s7ok4uw	5671	11	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5671	12	peptide	peptide	NN
cord-001835-0s7ok4uw	5671	13	has	have	VBZ
cord-001835-0s7ok4uw	5671	14	been	be	VBN
cord-001835-0s7ok4uw	5671	15	affected	affect	VBN
cord-001835-0s7ok4uw	5671	16	by	by	IN
cord-001835-0s7ok4uw	5671	17	the	the	DT
cord-001835-0s7ok4uw	5671	18	time	time	NN
cord-001835-0s7ok4uw	5671	19	interval	interval	NN
cord-001835-0s7ok4uw	5671	20	of	of	IN
cord-001835-0s7ok4uw	5671	21	the	the	DT
cord-001835-0s7ok4uw	5671	22	exercise	exercise	NN
cord-001835-0s7ok4uw	5671	23	.	.	.
cord-001835-0s7ok4uw	5672	1	Both	both	DT
cord-001835-0s7ok4uw	5672	2	cortisol	cortisol	NN
cord-001835-0s7ok4uw	5672	3	and	and	CC
cord-001835-0s7ok4uw	5672	4	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5672	5	peptide	peptide	NN
cord-001835-0s7ok4uw	5672	6	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	5672	7	a	a	DT
cord-001835-0s7ok4uw	5672	8	transient	transient	JJ
cord-001835-0s7ok4uw	5672	9	increase	increase	NN
cord-001835-0s7ok4uw	5672	10	after	after	IN
cord-001835-0s7ok4uw	5672	11	exercise	exercise	NN
cord-001835-0s7ok4uw	5672	12	but	but	CC
cord-001835-0s7ok4uw	5672	13	it	-PRON-	PRP
cord-001835-0s7ok4uw	5672	14	is	be	VBZ
cord-001835-0s7ok4uw	5672	15	surprising	surprising	JJ
cord-001835-0s7ok4uw	5672	16	that	that	IN
cord-001835-0s7ok4uw	5672	17	they	-PRON-	PRP
cord-001835-0s7ok4uw	5672	18	are	be	VBP
cord-001835-0s7ok4uw	5672	19	not	not	RB
cord-001835-0s7ok4uw	5672	20	correlate	correlate	JJ
cord-001835-0s7ok4uw	5672	21	to	to	IN
cord-001835-0s7ok4uw	5672	22	each	each	DT
cord-001835-0s7ok4uw	5672	23	other	other	JJ
cord-001835-0s7ok4uw	5672	24	.	.	.
cord-001835-0s7ok4uw	5673	1	One	one	CD
cord-001835-0s7ok4uw	5673	2	of	of	IN
cord-001835-0s7ok4uw	5673	3	the	the	DT
cord-001835-0s7ok4uw	5673	4	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	5673	5	from	from	IN
cord-001835-0s7ok4uw	5673	6	the	the	DT
cord-001835-0s7ok4uw	5673	7	present	present	JJ
cord-001835-0s7ok4uw	5673	8	finding	finding	NN
cord-001835-0s7ok4uw	5673	9	could	could	MD
cord-001835-0s7ok4uw	5673	10	be	be	VB
cord-001835-0s7ok4uw	5673	11	cortisol	cortisol	NN
cord-001835-0s7ok4uw	5673	12	responses	response	NNS
cord-001835-0s7ok4uw	5673	13	slow	slow	JJ
cord-001835-0s7ok4uw	5673	14	and	and	CC
cord-001835-0s7ok4uw	5673	15	it	-PRON-	PRP
cord-001835-0s7ok4uw	5673	16	will	will	MD
cord-001835-0s7ok4uw	5673	17	be	be	VB
cord-001835-0s7ok4uw	5673	18	interesting	interesting	JJ
cord-001835-0s7ok4uw	5673	19	to	to	TO
cord-001835-0s7ok4uw	5673	20	do	do	VB
cord-001835-0s7ok4uw	5673	21	further	further	JJ
cord-001835-0s7ok4uw	5673	22	research	research	NN
cord-001835-0s7ok4uw	5673	23	with	with	IN
cord-001835-0s7ok4uw	5673	24	longer	long	JJR
cord-001835-0s7ok4uw	5673	25	interval	interval	NN
cord-001835-0s7ok4uw	5673	26	.	.	.
cord-001835-0s7ok4uw	5674	1	The	the	DT
cord-001835-0s7ok4uw	5674	2	second	second	JJ
cord-001835-0s7ok4uw	5674	3	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	5674	4	demands	demand	VBZ
cord-001835-0s7ok4uw	5674	5	a	a	DT
cord-001835-0s7ok4uw	5674	6	further	further	JJ
cord-001835-0s7ok4uw	5674	7	investigation	investigation	NN
cord-001835-0s7ok4uw	5674	8	to	to	TO
cord-001835-0s7ok4uw	5674	9	determine	determine	VB
cord-001835-0s7ok4uw	5674	10	the	the	DT
cord-001835-0s7ok4uw	5674	11	synergism	synergism	NN
cord-001835-0s7ok4uw	5674	12	between	between	IN
cord-001835-0s7ok4uw	5674	13	substances	substance	NNS
cord-001835-0s7ok4uw	5674	14	.	.	.
cord-001835-0s7ok4uw	5675	1	School	school	NN
cord-001835-0s7ok4uw	5675	2	of	of	IN
cord-001835-0s7ok4uw	5675	3	Biomolecular	Biomolecular	NNP
cord-001835-0s7ok4uw	5675	4	and	and	CC
cord-001835-0s7ok4uw	5675	5	Biomedical	Biomedical	NNP
cord-001835-0s7ok4uw	5675	6	Science	Science	NNP
cord-001835-0s7ok4uw	5675	7	,	,	,
cord-001835-0s7ok4uw	5675	8	Conway	Conway	NNP
cord-001835-0s7ok4uw	5675	9	Institute	Institute	NNP
cord-001835-0s7ok4uw	5675	10	,	,	,
cord-001835-0s7ok4uw	5675	11	UCD	UCD	NNP
cord-001835-0s7ok4uw	5675	12	.	.	NNP
cord-001835-0s7ok4uw	5675	13	,	,	,
cord-001835-0s7ok4uw	5675	14	2	2	CD
cord-001835-0s7ok4uw	5675	15	King	King	NNP
cord-001835-0s7ok4uw	5675	16	Saud	Saud	NNP
cord-001835-0s7ok4uw	5675	17	University	University	NNP
cord-001835-0s7ok4uw	5675	18	,	,	,
cord-001835-0s7ok4uw	5675	19	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	5675	20	,	,	,
cord-001835-0s7ok4uw	5675	21	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	5675	22	department	department	NN
cord-001835-0s7ok4uw	5675	23	.	.	.
cord-001835-0s7ok4uw	5676	1	The	the	DT
cord-001835-0s7ok4uw	5676	2	crystal	crystal	JJ
cord-001835-0s7ok4uw	5676	3	structure	structure	NN
cord-001835-0s7ok4uw	5676	4	of	of	IN
cord-001835-0s7ok4uw	5676	5	a	a	DT
cord-001835-0s7ok4uw	5676	6	human	human	JJ
cord-001835-0s7ok4uw	5676	7	glucose	glucose	NN
cord-001835-0s7ok4uw	5676	8	6-phosphate	6-phosphate	NN
cord-001835-0s7ok4uw	5676	9	dehydrogenase	dehydrogenase	NN
cord-001835-0s7ok4uw	5676	10	(	(	-LRB-
cord-001835-0s7ok4uw	5676	11	G6PD	G6PD	NNP
cord-001835-0s7ok4uw	5676	12	)	)	-RRB-
cord-001835-0s7ok4uw	5676	13	shows	show	VBZ
cord-001835-0s7ok4uw	5676	14	that	that	IN
cord-001835-0s7ok4uw	5676	15	each	each	DT
cord-001835-0s7ok4uw	5676	16	subunit	subunit	NN
cord-001835-0s7ok4uw	5676	17	has	have	VBZ
cord-001835-0s7ok4uw	5676	18	two	two	CD
cord-001835-0s7ok4uw	5676	19	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	5676	20	sites	site	NNS
cord-001835-0s7ok4uw	5676	21	;	;	:
cord-001835-0s7ok4uw	5676	22	in	in	IN
cord-001835-0s7ok4uw	5676	23	addition	addition	NN
cord-001835-0s7ok4uw	5676	24	to	to	IN
cord-001835-0s7ok4uw	5676	25	a	a	DT
cord-001835-0s7ok4uw	5676	26	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5676	27	site	site	NN
cord-001835-0s7ok4uw	5676	28	there	there	EX
cord-001835-0s7ok4uw	5676	29	is	be	VBZ
cord-001835-0s7ok4uw	5676	30	a	a	DT
cord-001835-0s7ok4uw	5676	31	"	"	``
cord-001835-0s7ok4uw	5676	32	structural	structural	JJ
cord-001835-0s7ok4uw	5676	33	"	"	''
cord-001835-0s7ok4uw	5676	34	site	site	NN
cord-001835-0s7ok4uw	5676	35	which	which	WDT
cord-001835-0s7ok4uw	5676	36	is	be	VBZ
cord-001835-0s7ok4uw	5676	37	distant	distant	JJ
cord-001835-0s7ok4uw	5676	38	from	from	IN
cord-001835-0s7ok4uw	5676	39	the	the	DT
cord-001835-0s7ok4uw	5676	40	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5676	41	coenzyme	coenzyme	NNS
cord-001835-0s7ok4uw	5676	42	site	site	NN
cord-001835-0s7ok4uw	5676	43	.	.	.
cord-001835-0s7ok4uw	5677	1	Mutations	mutation	NNS
cord-001835-0s7ok4uw	5677	2	causing	cause	VBG
cord-001835-0s7ok4uw	5677	3	severe	severe	JJ
cord-001835-0s7ok4uw	5677	4	deficiency	deficiency	NN
cord-001835-0s7ok4uw	5677	5	tend	tend	VBP
cord-001835-0s7ok4uw	5677	6	to	to	TO
cord-001835-0s7ok4uw	5677	7	cluster	cluster	VB
cord-001835-0s7ok4uw	5677	8	round	round	RB
cord-001835-0s7ok4uw	5677	9	and	and	CC
cord-001835-0s7ok4uw	5677	10	close	close	RB
cord-001835-0s7ok4uw	5677	11	to	to	IN
cord-001835-0s7ok4uw	5677	12	the	the	DT
cord-001835-0s7ok4uw	5677	13	dimer	dimer	NN
cord-001835-0s7ok4uw	5677	14	interface	interface	NN
cord-001835-0s7ok4uw	5677	15	and	and	CC
cord-001835-0s7ok4uw	5677	16	the	the	DT
cord-001835-0s7ok4uw	5677	17	structural	structural	JJ
cord-001835-0s7ok4uw	5677	18	NADP1	nadp1	NN
cord-001835-0s7ok4uw	5677	19	,	,	,
cord-001835-0s7ok4uw	5677	20	indicating	indicate	VBG
cord-001835-0s7ok4uw	5677	21	that	that	IN
cord-001835-0s7ok4uw	5677	22	the	the	DT
cord-001835-0s7ok4uw	5677	23	integrity	integrity	NN
cord-001835-0s7ok4uw	5677	24	of	of	IN
cord-001835-0s7ok4uw	5677	25	these	these	DT
cord-001835-0s7ok4uw	5677	26	areas	area	NNS
cord-001835-0s7ok4uw	5677	27	is	be	VBZ
cord-001835-0s7ok4uw	5677	28	important	important	JJ
cord-001835-0s7ok4uw	5677	29	for	for	IN
cord-001835-0s7ok4uw	5677	30	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5677	31	stability	stability	NN
cord-001835-0s7ok4uw	5677	32	and	and	CC
cord-001835-0s7ok4uw	5677	33	therefore	therefore	RB
cord-001835-0s7ok4uw	5677	34	for	for	IN
cord-001835-0s7ok4uw	5677	35	maintenance	maintenance	NN
cord-001835-0s7ok4uw	5677	36	of	of	IN
cord-001835-0s7ok4uw	5677	37	activity	activity	NN
cord-001835-0s7ok4uw	5677	38	.	.	.
cord-001835-0s7ok4uw	5678	1	In	in	IN
cord-001835-0s7ok4uw	5678	2	order	order	NN
cord-001835-0s7ok4uw	5678	3	to	to	TO
cord-001835-0s7ok4uw	5678	4	understand	understand	VB
cord-001835-0s7ok4uw	5678	5	the	the	DT
cord-001835-0s7ok4uw	5678	6	molecular	molecular	JJ
cord-001835-0s7ok4uw	5678	7	basis	basis	NN
cord-001835-0s7ok4uw	5678	8	of	of	IN
cord-001835-0s7ok4uw	5678	9	G6PD	G6PD	NNP
cord-001835-0s7ok4uw	5678	10	deficiency	deficiency	NN
cord-001835-0s7ok4uw	5678	11	,	,	,
cord-001835-0s7ok4uw	5678	12	and	and	CC
cord-001835-0s7ok4uw	5678	13	to	to	TO
cord-001835-0s7ok4uw	5678	14	have	have	VB
cord-001835-0s7ok4uw	5678	15	a	a	DT
cord-001835-0s7ok4uw	5678	16	clearer	clear	JJR
cord-001835-0s7ok4uw	5678	17	indication	indication	NN
cord-001835-0s7ok4uw	5678	18	about	about	IN
cord-001835-0s7ok4uw	5678	19	the	the	DT
cord-001835-0s7ok4uw	5678	20	role	role	NN
cord-001835-0s7ok4uw	5678	21	of	of	IN
cord-001835-0s7ok4uw	5678	22	some	some	DT
cord-001835-0s7ok4uw	5678	23	features	feature	NNS
cord-001835-0s7ok4uw	5678	24	of	of	IN
cord-001835-0s7ok4uw	5678	25	the	the	DT
cord-001835-0s7ok4uw	5678	26	threedimensional	threedimensional	JJ
cord-001835-0s7ok4uw	5678	27	structure	structure	NN
cord-001835-0s7ok4uw	5678	28	,	,	,
cord-001835-0s7ok4uw	5678	29	a	a	DT
cord-001835-0s7ok4uw	5678	30	fuller	full	JJR
cord-001835-0s7ok4uw	5678	31	study	study	NN
cord-001835-0s7ok4uw	5678	32	of	of	IN
cord-001835-0s7ok4uw	5678	33	the	the	DT
cord-001835-0s7ok4uw	5678	34	second	second	JJ
cord-001835-0s7ok4uw	5678	35	,	,	,
cord-001835-0s7ok4uw	5678	36	"	"	``
cord-001835-0s7ok4uw	5678	37	structural	structural	JJ
cord-001835-0s7ok4uw	5678	38	"	"	''
cord-001835-0s7ok4uw	5678	39	NADP1	nadp1	NN
cord-001835-0s7ok4uw	5678	40	binding	binding	NN
cord-001835-0s7ok4uw	5678	41	site	site	NN
cord-001835-0s7ok4uw	5678	42	is	be	VBZ
cord-001835-0s7ok4uw	5678	43	needed	need	VBN
cord-001835-0s7ok4uw	5678	44	.	.	.
cord-001835-0s7ok4uw	5679	1	Human	human	JJ
cord-001835-0s7ok4uw	5679	2	G6PD	G6PD	NNP
cord-001835-0s7ok4uw	5679	3	controls	control	VBZ
cord-001835-0s7ok4uw	5679	4	the	the	DT
cord-001835-0s7ok4uw	5679	5	first	first	JJ
cord-001835-0s7ok4uw	5679	6	committed	committed	JJ
cord-001835-0s7ok4uw	5679	7	step	step	NN
cord-001835-0s7ok4uw	5679	8	in	in	IN
cord-001835-0s7ok4uw	5679	9	the	the	DT
cord-001835-0s7ok4uw	5679	10	pentose	pentose	NN
cord-001835-0s7ok4uw	5679	11	phosphate	phosphate	NN
cord-001835-0s7ok4uw	5679	12	pathway	pathway	NN
cord-001835-0s7ok4uw	5679	13	.	.	.
cord-001835-0s7ok4uw	5680	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5680	2	catalyses	catalyse	VBZ
cord-001835-0s7ok4uw	5680	3	the	the	DT
cord-001835-0s7ok4uw	5680	4	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5680	5	of	of	IN
cord-001835-0s7ok4uw	5680	6	glucose	glucose	NN
cord-001835-0s7ok4uw	5680	7	6-phosphate	6-phosphate	NN
cord-001835-0s7ok4uw	5680	8	to	to	IN
cord-001835-0s7ok4uw	5680	9	gluconolactone	gluconolactone	NN
cord-001835-0s7ok4uw	5680	10	6-phosphate	6-phosphate	CD
cord-001835-0s7ok4uw	5680	11	,	,	,
cord-001835-0s7ok4uw	5680	12	generating	generate	VBG
cord-001835-0s7ok4uw	5680	13	NADPH	NADPH	NNP
cord-001835-0s7ok4uw	5680	14	which	which	WDT
cord-001835-0s7ok4uw	5680	15	is	be	VBZ
cord-001835-0s7ok4uw	5680	16	essential	essential	JJ
cord-001835-0s7ok4uw	5680	17	,	,	,
cord-001835-0s7ok4uw	5680	18	amongst	amongst	IN
cord-001835-0s7ok4uw	5680	19	other	other	JJ
cord-001835-0s7ok4uw	5680	20	things	thing	NNS
cord-001835-0s7ok4uw	5680	21	,	,	,
cord-001835-0s7ok4uw	5680	22	for	for	IN
cord-001835-0s7ok4uw	5680	23	protection	protection	NN
cord-001835-0s7ok4uw	5680	24	against	against	IN
cord-001835-0s7ok4uw	5680	25	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	5680	26	stress	stress	NN
cord-001835-0s7ok4uw	5680	27	.	.	.
cord-001835-0s7ok4uw	5681	1	The	the	DT
cord-001835-0s7ok4uw	5681	2	human	human	JJ
cord-001835-0s7ok4uw	5681	3	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5681	4	can	can	MD
cord-001835-0s7ok4uw	5681	5	be	be	VB
cord-001835-0s7ok4uw	5681	6	active	active	JJ
cord-001835-0s7ok4uw	5681	7	in	in	IN
cord-001835-0s7ok4uw	5681	8	dimer	dimer	NN
cord-001835-0s7ok4uw	5681	9	or	or	CC
cord-001835-0s7ok4uw	5681	10	tetramer	tetramer	NN
cord-001835-0s7ok4uw	5681	11	forms	form	NNS
cord-001835-0s7ok4uw	5681	12	.	.	.
cord-001835-0s7ok4uw	5682	1	Human	human	JJ
cord-001835-0s7ok4uw	5682	2	G6PD	g6pd	NN
cord-001835-0s7ok4uw	5682	3	of	of	IN
cord-001835-0s7ok4uw	5682	4	"	"	``
cord-001835-0s7ok4uw	5682	5	structural	structural	JJ
cord-001835-0s7ok4uw	5682	6	"	"	''
cord-001835-0s7ok4uw	5682	7	NADP1	nadp1	NN
cord-001835-0s7ok4uw	5682	8	per	per	IN
cord-001835-0s7ok4uw	5682	9	subunit	subunit	NN
cord-001835-0s7ok4uw	5682	10	of	of	IN
cord-001835-0s7ok4uw	5682	11	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5682	12	.	.	.
cord-001835-0s7ok4uw	5683	1	This	this	DT
cord-001835-0s7ok4uw	5683	2	tightly	tightly	RB
cord-001835-0s7ok4uw	5683	3	-	-	HYPH
cord-001835-0s7ok4uw	5683	4	bound	bind	VBN
cord-001835-0s7ok4uw	5683	5	NADP1	nadp1	NN
cord-001835-0s7ok4uw	5683	6	can	can	MD
cord-001835-0s7ok4uw	5683	7	be	be	VB
cord-001835-0s7ok4uw	5683	8	reduced	reduce	VBN
cord-001835-0s7ok4uw	5683	9	by	by	IN
cord-001835-0s7ok4uw	5683	10	G6P	g6p	CD
cord-001835-0s7ok4uw	5683	11	,	,	,
cord-001835-0s7ok4uw	5683	12	probably	probably	RB
cord-001835-0s7ok4uw	5683	13	following	follow	VBG
cord-001835-0s7ok4uw	5683	14	migration	migration	NN
cord-001835-0s7ok4uw	5683	15	to	to	IN
cord-001835-0s7ok4uw	5683	16	the	the	DT
cord-001835-0s7ok4uw	5683	17	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5683	18	site	site	NN
cord-001835-0s7ok4uw	5683	19	.	.	.
cord-001835-0s7ok4uw	5684	1	The	the	DT
cord-001835-0s7ok4uw	5684	2	importance	importance	NN
cord-001835-0s7ok4uw	5684	3	of	of	IN
cord-001835-0s7ok4uw	5684	4	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	5684	5	for	for	IN
cord-001835-0s7ok4uw	5684	6	stability	stability	NN
cord-001835-0s7ok4uw	5684	7	is	be	VBZ
cord-001835-0s7ok4uw	5684	8	explained	explain	VBN
cord-001835-0s7ok4uw	5684	9	by	by	IN
cord-001835-0s7ok4uw	5684	10	the	the	DT
cord-001835-0s7ok4uw	5684	11	structural	structural	JJ
cord-001835-0s7ok4uw	5684	12	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	5684	13	site	site	NN
cord-001835-0s7ok4uw	5684	14	,	,	,
cord-001835-0s7ok4uw	5684	15	which	which	WDT
cord-001835-0s7ok4uw	5684	16	is	be	VBZ
cord-001835-0s7ok4uw	5684	17	not	not	RB
cord-001835-0s7ok4uw	5684	18	conserved	conserve	VBN
cord-001835-0s7ok4uw	5684	19	in	in	IN
cord-001835-0s7ok4uw	5684	20	prokaryotes	prokaryote	NNS
cord-001835-0s7ok4uw	5684	21	.	.	.
cord-001835-0s7ok4uw	5685	1	After	after	IN
cord-001835-0s7ok4uw	5685	2	removing	remove	VBG
cord-001835-0s7ok4uw	5685	3	the	the	DT
cord-001835-0s7ok4uw	5685	4	tightly	tightly	RB
cord-001835-0s7ok4uw	5685	5	bound	bind	VBN
cord-001835-0s7ok4uw	5685	6	"	"	''
cord-001835-0s7ok4uw	5685	7	structural	structural	JJ
cord-001835-0s7ok4uw	5685	8	"	"	''
cord-001835-0s7ok4uw	5685	9	NADP1	nadp1	NN
cord-001835-0s7ok4uw	5686	1	the	the	DT
cord-001835-0s7ok4uw	5686	2	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5686	3	is	be	VBZ
cord-001835-0s7ok4uw	5686	4	still	still	RB
cord-001835-0s7ok4uw	5686	5	active	active	JJ
cord-001835-0s7ok4uw	5686	6	but	but	CC
cord-001835-0s7ok4uw	5686	7	not	not	RB
cord-001835-0s7ok4uw	5686	8	stable	stable	JJ
cord-001835-0s7ok4uw	5686	9	.	.	.
cord-001835-0s7ok4uw	5687	1	The	the	DT
cord-001835-0s7ok4uw	5687	2	effects	effect	NNS
cord-001835-0s7ok4uw	5687	3	of	of	IN
cord-001835-0s7ok4uw	5687	4	different	different	JJ
cord-001835-0s7ok4uw	5687	5	NADP1	nadp1	NN
cord-001835-0s7ok4uw	5687	6	fragments	fragment	NNS
cord-001835-0s7ok4uw	5687	7	on	on	IN
cord-001835-0s7ok4uw	5687	8	the	the	DT
cord-001835-0s7ok4uw	5687	9	stability	stability	NN
cord-001835-0s7ok4uw	5687	10	of	of	IN
cord-001835-0s7ok4uw	5687	11	human	human	JJ
cord-001835-0s7ok4uw	5687	12	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	5687	13	G6PD	G6PD	NNP
cord-001835-0s7ok4uw	5687	14	have	have	VBP
cord-001835-0s7ok4uw	5687	15	been	be	VBN
cord-001835-0s7ok4uw	5687	16	investigated	investigate	VBN
cord-001835-0s7ok4uw	5687	17	.	.	.
cord-001835-0s7ok4uw	5688	1	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	5688	2	is	be	VBZ
cord-001835-0s7ok4uw	5688	3	crucial	crucial	JJ
cord-001835-0s7ok4uw	5688	4	for	for	IN
cord-001835-0s7ok4uw	5688	5	the	the	DT
cord-001835-0s7ok4uw	5688	6	long	long	JJ
cord-001835-0s7ok4uw	5688	7	term	term	NN
cord-001835-0s7ok4uw	5688	8	stability	stability	NN
cord-001835-0s7ok4uw	5688	9	of	of	IN
cord-001835-0s7ok4uw	5688	10	human	human	JJ
cord-001835-0s7ok4uw	5688	11	G6PD	G6PD	NNP
cord-001835-0s7ok4uw	5688	12	,	,	,
cord-001835-0s7ok4uw	5688	13	and	and	CC
cord-001835-0s7ok4uw	5688	14	only	only	RB
cord-001835-0s7ok4uw	5688	15	one	one	CD
cord-001835-0s7ok4uw	5688	16	of	of	IN
cord-001835-0s7ok4uw	5688	17	NADP1	NADP1	NNP
cord-001835-0s7ok4uw	5688	18	analogues	analogue	NNS
cord-001835-0s7ok4uw	5688	19	which	which	WDT
cord-001835-0s7ok4uw	5688	20	is	be	VBZ
cord-001835-0s7ok4uw	5688	21	adenosine	adenosine	NN
cord-001835-0s7ok4uw	5688	22	diphosphate	diphosphate	NN
cord-001835-0s7ok4uw	5688	23	ribose	ribose	NN
cord-001835-0s7ok4uw	5688	24	-2'-phosphate	-2'-phosphate	NN
cord-001835-0s7ok4uw	5688	25	was	be	VBD
cord-001835-0s7ok4uw	5688	26	able	able	JJ
cord-001835-0s7ok4uw	5688	27	to	to	TO
cord-001835-0s7ok4uw	5688	28	slightly	slightly	RB
cord-001835-0s7ok4uw	5688	29	promote	promote	VB
cord-001835-0s7ok4uw	5688	30	the	the	DT
cord-001835-0s7ok4uw	5688	31	stability	stability	NN
cord-001835-0s7ok4uw	5688	32	of	of	IN
cord-001835-0s7ok4uw	5688	33	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5688	34	.	.	.
cord-001835-0s7ok4uw	5688	35	.	.	.
cord-001835-0s7ok4uw	5689	1	Molecular	molecular	JJ
cord-001835-0s7ok4uw	5689	2	characterization	characterization	NN
cord-001835-0s7ok4uw	5689	3	of	of	IN
cord-001835-0s7ok4uw	5689	4	specific	specific	JJ
cord-001835-0s7ok4uw	5689	5	positively	positively	RB
cord-001835-0s7ok4uw	5689	6	selected	select	VBN
cord-001835-0s7ok4uw	5689	7	sites	site	NNS
cord-001835-0s7ok4uw	5689	8	in	in	IN
cord-001835-0s7ok4uw	5689	9	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	5689	10	visual	visual	JJ
cord-001835-0s7ok4uw	5689	11	pigment	pigment	NN
cord-001835-0s7ok4uw	5689	12	evolution	evolution	NN
cord-001835-0s7ok4uw	5690	1	Miguel	Miguel	NNP
cord-001835-0s7ok4uw	5690	2	A.	a.	NN
cord-001835-0s7ok4uw	5690	3	Fern	Fern	NNP
cord-001835-0s7ok4uw	5691	1	andez	andez	NNP
cord-001835-0s7ok4uw	5691	2	-	-	HYPH
cord-001835-0s7ok4uw	5691	3	Sampedro	Sampedro	NNP
cord-001835-0s7ok4uw	5691	4	1	1	CD
cord-001835-0s7ok4uw	5691	5	,	,	,
cord-001835-0s7ok4uw	5691	6	Eva	Eva	NNP
cord-001835-0s7ok4uw	5691	7	Ramon	Ramon	NNP
cord-001835-0s7ok4uw	5691	8	1	1	CD
cord-001835-0s7ok4uw	5691	9	,	,	,
cord-001835-0s7ok4uw	5691	10	Brandon	Brandon	NNP
cord-001835-0s7ok4uw	5691	11	M.	M.	NNP
cord-001835-0s7ok4uw	5691	12	Invergo	Invergo	NNP
cord-001835-0s7ok4uw	5691	13	2	2	CD
cord-001835-0s7ok4uw	5691	14	,	,	,
cord-001835-0s7ok4uw	5691	15	Jaume	Jaume	NNP
cord-001835-0s7ok4uw	5691	16	Bertranpetit	Bertranpetit	NNP
cord-001835-0s7ok4uw	5691	17	2	2	CD
cord-001835-0s7ok4uw	5691	18	,	,	,
cord-001835-0s7ok4uw	5691	19	Pere	Pere	NNP
cord-001835-0s7ok4uw	5691	20	Garriga	Garriga	NNP
cord-001835-0s7ok4uw	5692	1	1	1	CD
cord-001835-0s7ok4uw	5692	2	1	1	CD
cord-001835-0s7ok4uw	5692	3	Grup	Grup	NNP
cord-001835-0s7ok4uw	5692	4	de	de	NNP
cord-001835-0s7ok4uw	5692	5	Biotecnologia	Biotecnologia	NNP
cord-001835-0s7ok4uw	5692	6	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	5692	7	i	i	VBD
cord-001835-0s7ok4uw	5692	8	Industrial	Industrial	NNP
cord-001835-0s7ok4uw	5692	9	.	.	.
cord-001835-0s7ok4uw	5693	1	,	,	,
cord-001835-0s7ok4uw	5693	2	2	2	CD
cord-001835-0s7ok4uw	5693	3	 	 	_SP
cord-001835-0s7ok4uw	5693	4	Visual	visual	JJ
cord-001835-0s7ok4uw	5693	5	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	5693	6	is	be	VBZ
cord-001835-0s7ok4uw	5693	7	a	a	DT
cord-001835-0s7ok4uw	5693	8	member	member	NN
cord-001835-0s7ok4uw	5693	9	of	of	IN
cord-001835-0s7ok4uw	5693	10	the	the	DT
cord-001835-0s7ok4uw	5693	11	G	g	NN
cord-001835-0s7ok4uw	5693	12	-	-	HYPH
cord-001835-0s7ok4uw	5693	13	protein	protein	NN
cord-001835-0s7ok4uw	5693	14	coupled	coupled	JJ
cord-001835-0s7ok4uw	5693	15	receptors	receptor	NNS
cord-001835-0s7ok4uw	5693	16	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5693	17	.	.	.
cord-001835-0s7ok4uw	5694	1	This	this	DT
cord-001835-0s7ok4uw	5694	2	membrane	membrane	NN
cord-001835-0s7ok4uw	5694	3	protein	protein	NN
cord-001835-0s7ok4uw	5694	4	consists	consist	VBZ
cord-001835-0s7ok4uw	5694	5	of	of	IN
cord-001835-0s7ok4uw	5694	6	a	a	DT
cord-001835-0s7ok4uw	5694	7	11-cis	11-cis	CD
cord-001835-0s7ok4uw	5694	8	-	-	HYPH
cord-001835-0s7ok4uw	5694	9	retinal	retinal	JJ
cord-001835-0s7ok4uw	5694	10	cromophore	cromophore	NN
cord-001835-0s7ok4uw	5694	11	bound	bind	VBN
cord-001835-0s7ok4uw	5694	12	to	to	IN
cord-001835-0s7ok4uw	5694	13	a	a	DT
cord-001835-0s7ok4uw	5694	14	seven	seven	CD
cord-001835-0s7ok4uw	5694	15	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	5694	16	protein	protein	NN
cord-001835-0s7ok4uw	5694	17	,	,	,
cord-001835-0s7ok4uw	5694	18	opsin	opsin	NN
cord-001835-0s7ok4uw	5694	19	,	,	,
cord-001835-0s7ok4uw	5694	20	by	by	IN
cord-001835-0s7ok4uw	5694	21	means	mean	NNS
cord-001835-0s7ok4uw	5694	22	of	of	IN
cord-001835-0s7ok4uw	5694	23	a	a	DT
cord-001835-0s7ok4uw	5694	24	protonated	protonated	JJ
cord-001835-0s7ok4uw	5694	25	Schiff	Schiff	NNP
cord-001835-0s7ok4uw	5694	26	base	base	NN
cord-001835-0s7ok4uw	5694	27	linkage	linkage	NN
cord-001835-0s7ok4uw	5694	28	.	.	.
cord-001835-0s7ok4uw	5695	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5695	2	has	have	VBZ
cord-001835-0s7ok4uw	5695	3	an	an	DT
cord-001835-0s7ok4uw	5695	4	important	important	JJ
cord-001835-0s7ok4uw	5695	5	role	role	NN
cord-001835-0s7ok4uw	5695	6	as	as	IN
cord-001835-0s7ok4uw	5695	7	a	a	DT
cord-001835-0s7ok4uw	5695	8	dim	dim	JJ
cord-001835-0s7ok4uw	5695	9	light	light	JJ
cord-001835-0s7ok4uw	5695	10	photoreceptor	photoreceptor	NN
cord-001835-0s7ok4uw	5695	11	in	in	IN
cord-001835-0s7ok4uw	5695	12	the	the	DT
cord-001835-0s7ok4uw	5695	13	retina	retina	NN
cord-001835-0s7ok4uw	5695	14	of	of	IN
cord-001835-0s7ok4uw	5695	15	the	the	DT
cord-001835-0s7ok4uw	5695	16	eye	eye	NN
cord-001835-0s7ok4uw	5695	17	.	.	.
cord-001835-0s7ok4uw	5696	1	By	by	IN
cord-001835-0s7ok4uw	5696	2	statistical	statistical	JJ
cord-001835-0s7ok4uw	5696	3	models	model	NNS
cord-001835-0s7ok4uw	5696	4	,	,	,
cord-001835-0s7ok4uw	5696	5	where	where	WRB
cord-001835-0s7ok4uw	5696	6	episodic	episodic	JJ
cord-001835-0s7ok4uw	5696	7	selection	selection	NN
cord-001835-0s7ok4uw	5696	8	in	in	IN
cord-001835-0s7ok4uw	5696	9	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	5696	10	is	be	VBZ
cord-001835-0s7ok4uw	5696	11	tested	test	VBN
cord-001835-0s7ok4uw	5696	12	on	on	IN
cord-001835-0s7ok4uw	5696	13	one	one	CD
cord-001835-0s7ok4uw	5696	14	branch	branch	NN
cord-001835-0s7ok4uw	5696	15	of	of	IN
cord-001835-0s7ok4uw	5696	16	the	the	DT
cord-001835-0s7ok4uw	5696	17	phylogeny	phylogeny	NN
cord-001835-0s7ok4uw	5696	18	against	against	IN
cord-001835-0s7ok4uw	5696	19	a	a	DT
cord-001835-0s7ok4uw	5696	20	background	background	NN
cord-001835-0s7ok4uw	5696	21	of	of	IN
cord-001835-0s7ok4uw	5696	22	neutral	neutral	JJ
cord-001835-0s7ok4uw	5696	23	or	or	CC
cord-001835-0s7ok4uw	5696	24	purifying	purify	VBG
cord-001835-0s7ok4uw	5696	25	selection	selection	NN
cord-001835-0s7ok4uw	5696	26	on	on	IN
cord-001835-0s7ok4uw	5696	27	the	the	DT
cord-001835-0s7ok4uw	5696	28	rest	rest	NN
cord-001835-0s7ok4uw	5696	29	of	of	IN
cord-001835-0s7ok4uw	5696	30	the	the	DT
cord-001835-0s7ok4uw	5696	31	tree	tree	NN
cord-001835-0s7ok4uw	5696	32	,	,	,
cord-001835-0s7ok4uw	5696	33	we	-PRON-	PRP
cord-001835-0s7ok4uw	5696	34	have	have	VBP
cord-001835-0s7ok4uw	5696	35	found	find	VBN
cord-001835-0s7ok4uw	5696	36	some	some	DT
cord-001835-0s7ok4uw	5696	37	significant	significant	JJ
cord-001835-0s7ok4uw	5696	38	evidence	evidence	NN
cord-001835-0s7ok4uw	5696	39	of	of	IN
cord-001835-0s7ok4uw	5696	40	specific	specific	JJ
cord-001835-0s7ok4uw	5696	41	positively	positively	RB
cord-001835-0s7ok4uw	5696	42	selected	select	VBN
cord-001835-0s7ok4uw	5696	43	sites	site	NNS
cord-001835-0s7ok4uw	5696	44	in	in	IN
cord-001835-0s7ok4uw	5696	45	early	early	JJ
cord-001835-0s7ok4uw	5696	46	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	5696	47	divergence	divergence	NN
cord-001835-0s7ok4uw	5696	48	.	.	.
cord-001835-0s7ok4uw	5697	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5697	2	have	have	VBP
cord-001835-0s7ok4uw	5697	3	chosen	choose	VBN
cord-001835-0s7ok4uw	5697	4	the	the	DT
cord-001835-0s7ok4uw	5697	5	three	three	CD
cord-001835-0s7ok4uw	5697	6	amino	amino	NN
cord-001835-0s7ok4uw	5697	7	acid	acid	NN
cord-001835-0s7ok4uw	5697	8	sites	site	NNS
cord-001835-0s7ok4uw	5697	9	identified	identify	VBN
cord-001835-0s7ok4uw	5697	10	with	with	IN
cord-001835-0s7ok4uw	5697	11	the	the	DT
cord-001835-0s7ok4uw	5697	12	highest	high	JJS
cord-001835-0s7ok4uw	5697	13	posterior	posterior	JJ
cord-001835-0s7ok4uw	5697	14	probability	probability	NN
cord-001835-0s7ok4uw	5697	15	of	of	IN
cord-001835-0s7ok4uw	5697	16	having	have	VBG
cord-001835-0s7ok4uw	5697	17	been	be	VBN
cord-001835-0s7ok4uw	5697	18	targets	target	NNS
cord-001835-0s7ok4uw	5697	19	of	of	IN
cord-001835-0s7ok4uw	5697	20	positive	positive	JJ
cord-001835-0s7ok4uw	5697	21	selection	selection	NN
cord-001835-0s7ok4uw	5697	22	to	to	TO
cord-001835-0s7ok4uw	5697	23	perform	perform	VB
cord-001835-0s7ok4uw	5697	24	experimental	experimental	JJ
cord-001835-0s7ok4uw	5697	25	studies	study	NNS
cord-001835-0s7ok4uw	5697	26	,	,	,
cord-001835-0s7ok4uw	5697	27	i.e.	i.e.	FW
cord-001835-0s7ok4uw	5697	28	13	13	CD
cord-001835-0s7ok4uw	5697	29	(	(	-LRB-
cord-001835-0s7ok4uw	5697	30	positively	positively	RB
cord-001835-0s7ok4uw	5697	31	selected	select	VBN
cord-001835-0s7ok4uw	5697	32	from	from	IN
cord-001835-0s7ok4uw	5697	33	M	M	NNP
cord-001835-0s7ok4uw	5697	34	to	to	IN
cord-001835-0s7ok4uw	5697	35	F	F	NNP
cord-001835-0s7ok4uw	5697	36	)	)	-RRB-
cord-001835-0s7ok4uw	5697	37	,	,	,
cord-001835-0s7ok4uw	5697	38	225	225	CD
cord-001835-0s7ok4uw	5697	39	(	(	-LRB-
cord-001835-0s7ok4uw	5697	40	positively	positively	RB
cord-001835-0s7ok4uw	5697	41	selected	select	VBN
cord-001835-0s7ok4uw	5697	42	from	from	IN
cord-001835-0s7ok4uw	5697	43	R	r	NN
cord-001835-0s7ok4uw	5697	44	to	to	IN
cord-001835-0s7ok4uw	5697	45	Q	Q	NNP
cord-001835-0s7ok4uw	5697	46	)	)	-RRB-
cord-001835-0s7ok4uw	5697	47	and	and	CC
cord-001835-0s7ok4uw	5697	48	346	346	CD
cord-001835-0s7ok4uw	5697	49	(	(	-LRB-
cord-001835-0s7ok4uw	5697	50	positively	positively	RB
cord-001835-0s7ok4uw	5697	51	selected	select	VBN
cord-001835-0s7ok4uw	5697	52	from	from	IN
cord-001835-0s7ok4uw	5697	53	S	S	NNP
cord-001835-0s7ok4uw	5697	54	to	to	IN
cord-001835-0s7ok4uw	5697	55	A	a	NN
cord-001835-0s7ok4uw	5697	56	)	)	-RRB-
cord-001835-0s7ok4uw	5697	57	.	.	.
cord-001835-0s7ok4uw	5698	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5698	2	have	have	VBP
cord-001835-0s7ok4uw	5698	3	constructed	construct	VBN
cord-001835-0s7ok4uw	5698	4	,	,	,
cord-001835-0s7ok4uw	5698	5	expressed	express	VBN
cord-001835-0s7ok4uw	5698	6	,	,	,
cord-001835-0s7ok4uw	5698	7	immunopurified	immunopurifie	VBN
cord-001835-0s7ok4uw	5698	8	and	and	CC
cord-001835-0s7ok4uw	5698	9	functionally	functionally	RB
cord-001835-0s7ok4uw	5698	10	characterized	characterize	VBD
cord-001835-0s7ok4uw	5698	11	the	the	DT
cord-001835-0s7ok4uw	5698	12	proposed	propose	VBN
cord-001835-0s7ok4uw	5698	13	candidates	candidate	NNS
cord-001835-0s7ok4uw	5698	14	,	,	,
cord-001835-0s7ok4uw	5698	15	F13	F13	NNP
cord-001835-0s7ok4uw	5698	16	M	M	NNP
cord-001835-0s7ok4uw	5698	17	,	,	,
cord-001835-0s7ok4uw	5698	18	Q225R	Q225R	NNP
cord-001835-0s7ok4uw	5698	19	and	and	CC
cord-001835-0s7ok4uw	5698	20	A346S	a346s	NN
cord-001835-0s7ok4uw	5698	21	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	5698	22	mutants	mutant	NNS
cord-001835-0s7ok4uw	5698	23	located	locate	VBN
cord-001835-0s7ok4uw	5698	24	at	at	IN
cord-001835-0s7ok4uw	5698	25	the	the	DT
cord-001835-0s7ok4uw	5698	26	N	n	CD
cord-001835-0s7ok4uw	5698	27	-	-	HYPH
cord-001835-0s7ok4uw	5698	28	terminus	terminus	NN
cord-001835-0s7ok4uw	5698	29	,	,	,
cord-001835-0s7ok4uw	5698	30	the	the	DT
cord-001835-0s7ok4uw	5698	31	transmembrane	transmembrane	NN
cord-001835-0s7ok4uw	5698	32	domain	domain	NN
cord-001835-0s7ok4uw	5698	33	and	and	CC
cord-001835-0s7ok4uw	5698	34	the	the	DT
cord-001835-0s7ok4uw	5698	35	C	c	NN
cord-001835-0s7ok4uw	5698	36	-	-	HYPH
cord-001835-0s7ok4uw	5698	37	terminus	terminus	NN
cord-001835-0s7ok4uw	5698	38	region	region	NN
cord-001835-0s7ok4uw	5698	39	of	of	IN
cord-001835-0s7ok4uw	5698	40	the	the	DT
cord-001835-0s7ok4uw	5698	41	protein	protein	NN
cord-001835-0s7ok4uw	5698	42	respectively	respectively	RB
cord-001835-0s7ok4uw	5698	43	.	.	.
cord-001835-0s7ok4uw	5699	1	From	from	IN
cord-001835-0s7ok4uw	5699	2	the	the	DT
cord-001835-0s7ok4uw	5699	3	analysis	analysis	NN
cord-001835-0s7ok4uw	5699	4	of	of	IN
cord-001835-0s7ok4uw	5699	5	the	the	DT
cord-001835-0s7ok4uw	5699	6	molecular	molecular	JJ
cord-001835-0s7ok4uw	5699	7	features	feature	NNS
cord-001835-0s7ok4uw	5699	8	of	of	IN
cord-001835-0s7ok4uw	5699	9	the	the	DT
cord-001835-0s7ok4uw	5699	10	F13	F13	NNP
cord-001835-0s7ok4uw	5699	11	M	M	NNP
cord-001835-0s7ok4uw	5699	12	mutant	mutant	NN
cord-001835-0s7ok4uw	5699	13	,	,	,
cord-001835-0s7ok4uw	5699	14	we	-PRON-	PRP
cord-001835-0s7ok4uw	5699	15	conclude	conclude	VBP
cord-001835-0s7ok4uw	5699	16	that	that	IN
cord-001835-0s7ok4uw	5699	17	position	position	NN
cord-001835-0s7ok4uw	5699	18	13	13	CD
cord-001835-0s7ok4uw	5699	19	is	be	VBZ
cord-001835-0s7ok4uw	5699	20	very	very	RB
cord-001835-0s7ok4uw	5699	21	important	important	JJ
cord-001835-0s7ok4uw	5699	22	for	for	IN
cord-001835-0s7ok4uw	5699	23	protein	protein	NN
cord-001835-0s7ok4uw	5699	24	folding	folding	NN
cord-001835-0s7ok4uw	5699	25	and	and	CC
cord-001835-0s7ok4uw	5699	26	also	also	RB
cord-001835-0s7ok4uw	5699	27	for	for	IN
cord-001835-0s7ok4uw	5699	28	proper	proper	JJ
cord-001835-0s7ok4uw	5699	29	protein	protein	NN
cord-001835-0s7ok4uw	5699	30	glycosylation	glycosylation	NN
cord-001835-0s7ok4uw	5699	31	,	,	,
cord-001835-0s7ok4uw	5699	32	since	since	IN
cord-001835-0s7ok4uw	5699	33	we	-PRON-	PRP
cord-001835-0s7ok4uw	5699	34	only	only	RB
cord-001835-0s7ok4uw	5699	35	could	could	MD
cord-001835-0s7ok4uw	5699	36	observe	observe	VB
cord-001835-0s7ok4uw	5699	37	cromophore	cromophore	JJ
cord-001835-0s7ok4uw	5699	38	regeneration	regeneration	NN
cord-001835-0s7ok4uw	5699	39	after	after	IN
cord-001835-0s7ok4uw	5699	40	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5699	41	rescue	rescue	NN
cord-001835-0s7ok4uw	5699	42	in	in	IN
cord-001835-0s7ok4uw	5699	43	the	the	DT
cord-001835-0s7ok4uw	5699	44	double	double	JJ
cord-001835-0s7ok4uw	5699	45	cysteine	cysteine	NN
cord-001835-0s7ok4uw	5699	46	(	(	-LRB-
cord-001835-0s7ok4uw	5699	47	N2C/	N2C/	NNP
cord-001835-0s7ok4uw	5699	48	D282C	d282c	NN
cord-001835-0s7ok4uw	5699	49	)	)	-RRB-
cord-001835-0s7ok4uw	5699	50	mutant	mutant	JJ
cord-001835-0s7ok4uw	5699	51	background	background	NN
cord-001835-0s7ok4uw	5699	52	that	that	WDT
cord-001835-0s7ok4uw	5699	53	stabilizes	stabilize	VBZ
cord-001835-0s7ok4uw	5699	54	the	the	DT
cord-001835-0s7ok4uw	5699	55	N	n	CD
cord-001835-0s7ok4uw	5699	56	-	-	HYPH
cord-001835-0s7ok4uw	5699	57	terminal	terminal	NN
cord-001835-0s7ok4uw	5699	58	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	5699	59	domain	domain	NN
cord-001835-0s7ok4uw	5699	60	of	of	IN
cord-001835-0s7ok4uw	5699	61	the	the	DT
cord-001835-0s7ok4uw	5699	62	protein	protein	NN
cord-001835-0s7ok4uw	5699	63	.	.	.
cord-001835-0s7ok4uw	5700	1	Our	-PRON-	PRP$
cord-001835-0s7ok4uw	5700	2	results	result	NNS
cord-001835-0s7ok4uw	5700	3	also	also	RB
cord-001835-0s7ok4uw	5700	4	show	show	VBP
cord-001835-0s7ok4uw	5700	5	that	that	IN
cord-001835-0s7ok4uw	5700	6	mutants	mutant	NNS
cord-001835-0s7ok4uw	5700	7	Q225R	Q225R	NNP
cord-001835-0s7ok4uw	5700	8	and	and	CC
cord-001835-0s7ok4uw	5700	9	A346S	A346S	NNP
cord-001835-0s7ok4uw	5700	10	alter	alter	VB
cord-001835-0s7ok4uw	5700	11	the	the	DT
cord-001835-0s7ok4uw	5700	12	G	g	NN
cord-001835-0s7ok4uw	5700	13	-	-	HYPH
cord-001835-0s7ok4uw	5700	14	protein	protein	NN
cord-001835-0s7ok4uw	5700	15	activation	activation	NN
cord-001835-0s7ok4uw	5700	16	rate	rate	NN
cord-001835-0s7ok4uw	5700	17	,	,	,
cord-001835-0s7ok4uw	5700	18	and	and	CC
cord-001835-0s7ok4uw	5700	19	hydroxylamine	hydroxylamine	JJ
cord-001835-0s7ok4uw	5700	20	susceptibility	susceptibility	NN
cord-001835-0s7ok4uw	5700	21	in	in	IN
cord-001835-0s7ok4uw	5700	22	the	the	DT
cord-001835-0s7ok4uw	5700	23	dark	dark	RB
cord-001835-0s7ok4uw	5700	24	-	-	HYPH
cord-001835-0s7ok4uw	5700	25	adapted	adapt	VBN
cord-001835-0s7ok4uw	5700	26	state	state	NN
cord-001835-0s7ok4uw	5700	27	.	.	.
cord-001835-0s7ok4uw	5701	1	In	in	IN
cord-001835-0s7ok4uw	5701	2	the	the	DT
cord-001835-0s7ok4uw	5701	3	case	case	NN
cord-001835-0s7ok4uw	5701	4	of	of	IN
cord-001835-0s7ok4uw	5701	5	Q225R	Q225R	NNP
cord-001835-0s7ok4uw	5701	6	,	,	,
cord-001835-0s7ok4uw	5701	7	disrupting	disrupt	VBG
cord-001835-0s7ok4uw	5701	8	critical	critical	JJ
cord-001835-0s7ok4uw	5701	9	interactions	interaction	NNS
cord-001835-0s7ok4uw	5701	10	with	with	IN
cord-001835-0s7ok4uw	5701	11	the	the	DT
cord-001835-0s7ok4uw	5701	12	neighbouring	neighbouring	NN
cord-001835-0s7ok4uw	5701	13	Y136	y136	CD
cord-001835-0s7ok4uw	5701	14	of	of	IN
cord-001835-0s7ok4uw	5701	15	the	the	DT
cord-001835-0s7ok4uw	5701	16	conserved	conserve	VBN
cord-001835-0s7ok4uw	5701	17	D	D	NNP
cord-001835-0s7ok4uw	5701	18	/	/	SYM
cord-001835-0s7ok4uw	5701	19	ERY	ery	JJ
cord-001835-0s7ok4uw	5701	20	motif	motif	NN
cord-001835-0s7ok4uw	5701	21	,	,	,
cord-001835-0s7ok4uw	5701	22	critical	critical	JJ
cord-001835-0s7ok4uw	5701	23	in	in	IN
cord-001835-0s7ok4uw	5701	24	Gt	Gt	NNP
cord-001835-0s7ok4uw	5701	25	activation	activation	NN
cord-001835-0s7ok4uw	5701	26	,	,	,
cord-001835-0s7ok4uw	5701	27	could	could	MD
cord-001835-0s7ok4uw	5701	28	cause	cause	VB
cord-001835-0s7ok4uw	5701	29	the	the	DT
cord-001835-0s7ok4uw	5701	30	lower	low	JJR
cord-001835-0s7ok4uw	5701	31	Gt	Gt	NNP
cord-001835-0s7ok4uw	5701	32	activation	activation	NN
cord-001835-0s7ok4uw	5701	33	ability	ability	NN
cord-001835-0s7ok4uw	5701	34	.	.	.
cord-001835-0s7ok4uw	5702	1	The	the	DT
cord-001835-0s7ok4uw	5702	2	mutant	mutant	JJ
cord-001835-0s7ok4uw	5702	3	A346S	A346S	NNP
cord-001835-0s7ok4uw	5702	4	would	would	MD
cord-001835-0s7ok4uw	5702	5	create	create	VB
cord-001835-0s7ok4uw	5702	6	a	a	DT
cord-001835-0s7ok4uw	5702	7	potential	potential	JJ
cord-001835-0s7ok4uw	5702	8	additional	additional	JJ
cord-001835-0s7ok4uw	5702	9	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	5702	10	site	site	NN
cord-001835-0s7ok4uw	5702	11	in	in	IN
cord-001835-0s7ok4uw	5702	12	the	the	DT
cord-001835-0s7ok4uw	5702	13	protein	protein	NN
cord-001835-0s7ok4uw	5702	14	which	which	WDT
cord-001835-0s7ok4uw	5702	15	could	could	MD
cord-001835-0s7ok4uw	5702	16	affect	affect	VB
cord-001835-0s7ok4uw	5702	17	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	5702	18	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	5702	19	after	after	IN
cord-001835-0s7ok4uw	5702	20	photoactivation	photoactivation	NN
cord-001835-0s7ok4uw	5702	21	and	and	CC
cord-001835-0s7ok4uw	5702	22	,	,	,
cord-001835-0s7ok4uw	5702	23	in	in	IN
cord-001835-0s7ok4uw	5702	24	turn	turn	NN
cord-001835-0s7ok4uw	5702	25	,	,	,
cord-001835-0s7ok4uw	5702	26	could	could	MD
cord-001835-0s7ok4uw	5702	27	affect	affect	VB
cord-001835-0s7ok4uw	5702	28	the	the	DT
cord-001835-0s7ok4uw	5702	29	binding	bind	VBG
cord-001835-0s7ok4uw	5702	30	affinity	affinity	NN
cord-001835-0s7ok4uw	5702	31	of	of	IN
cord-001835-0s7ok4uw	5702	32	arrestin	arrestin	NNP
cord-001835-0s7ok4uw	5702	33	,	,	,
cord-001835-0s7ok4uw	5702	34	a	a	DT
cord-001835-0s7ok4uw	5702	35	regulator	regulator	NN
cord-001835-0s7ok4uw	5702	36	of	of	IN
cord-001835-0s7ok4uw	5702	37	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	5702	38	deactivation	deactivation	NN
cord-001835-0s7ok4uw	5702	39	.	.	.
cord-001835-0s7ok4uw	5703	1	This	this	DT
cord-001835-0s7ok4uw	5703	2	extra	extra	JJ
cord-001835-0s7ok4uw	5703	3	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	5703	4	site	site	NN
cord-001835-0s7ok4uw	5703	5	could	could	MD
cord-001835-0s7ok4uw	5703	6	provide	provide	VB
cord-001835-0s7ok4uw	5703	7	an	an	DT
cord-001835-0s7ok4uw	5703	8	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	5703	9	explanation	explanation	NN
cord-001835-0s7ok4uw	5703	10	for	for	IN
cord-001835-0s7ok4uw	5703	11	the	the	DT
cord-001835-0s7ok4uw	5703	12	enhanced	enhanced	JJ
cord-001835-0s7ok4uw	5703	13	response	response	NN
cord-001835-0s7ok4uw	5703	14	observed	observe	VBN
cord-001835-0s7ok4uw	5703	15	in	in	IN
cord-001835-0s7ok4uw	5703	16	the	the	DT
cord-001835-0s7ok4uw	5703	17	case	case	NN
cord-001835-0s7ok4uw	5703	18	of	of	IN
cord-001835-0s7ok4uw	5703	19	Gt	Gt	NNP
cord-001835-0s7ok4uw	5703	20	activation	activation	NN
cord-001835-0s7ok4uw	5703	21	.	.	.
cord-001835-0s7ok4uw	5704	1	In	in	IN
cord-001835-0s7ok4uw	5704	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	5704	3	,	,	,
cord-001835-0s7ok4uw	5704	4	these	these	DT
cord-001835-0s7ok4uw	5704	5	results	result	NNS
cord-001835-0s7ok4uw	5704	6	highlight	highlight	VBP
cord-001835-0s7ok4uw	5704	7	the	the	DT
cord-001835-0s7ok4uw	5704	8	importance	importance	NN
cord-001835-0s7ok4uw	5704	9	of	of	IN
cord-001835-0s7ok4uw	5704	10	molecular	molecular	JJ
cord-001835-0s7ok4uw	5704	11	investigations	investigation	NNS
cord-001835-0s7ok4uw	5704	12	of	of	IN
cord-001835-0s7ok4uw	5704	13	positive	positive	JJ
cord-001835-0s7ok4uw	5704	14	selected	select	VBN
cord-001835-0s7ok4uw	5704	15	sites	site	NNS
cord-001835-0s7ok4uw	5704	16	in	in	IN
cord-001835-0s7ok4uw	5704	17	rhodopsin	rhodopsin	NN
cord-001835-0s7ok4uw	5704	18	evolution	evolution	NN
cord-001835-0s7ok4uw	5704	19	and	and	CC
cord-001835-0s7ok4uw	5704	20	the	the	DT
cord-001835-0s7ok4uw	5704	21	relevance	relevance	NN
cord-001835-0s7ok4uw	5704	22	of	of	IN
cord-001835-0s7ok4uw	5704	23	structural	structural	JJ
cord-001835-0s7ok4uw	5704	24	and	and	CC
cord-001835-0s7ok4uw	5704	25	functional	functional	JJ
cord-001835-0s7ok4uw	5704	26	analysis	analysis	NN
cord-001835-0s7ok4uw	5704	27	of	of	IN
cord-001835-0s7ok4uw	5704	28	these	these	DT
cord-001835-0s7ok4uw	5704	29	sites	site	NNS
cord-001835-0s7ok4uw	5704	30	in	in	IN
cord-001835-0s7ok4uw	5704	31	unravelling	unravel	VBG
cord-001835-0s7ok4uw	5704	32	the	the	DT
cord-001835-0s7ok4uw	5704	33	molecular	molecular	JJ
cord-001835-0s7ok4uw	5704	34	basis	basis	NN
cord-001835-0s7ok4uw	5704	35	of	of	IN
cord-001835-0s7ok4uw	5704	36	visual	visual	JJ
cord-001835-0s7ok4uw	5704	37	pigment	pigment	NN
cord-001835-0s7ok4uw	5704	38	evolution	evolution	NN
cord-001835-0s7ok4uw	5704	39	.	.	.
cord-001835-0s7ok4uw	5705	1	Natural	natural	JJ
cord-001835-0s7ok4uw	5705	2	evolution	evolution	NN
cord-001835-0s7ok4uw	5705	3	sheds	shed	VBZ
cord-001835-0s7ok4uw	5705	4	light	light	NN
cord-001835-0s7ok4uw	5705	5	on	on	IN
cord-001835-0s7ok4uw	5705	6	modern	modern	JJ
cord-001835-0s7ok4uw	5705	7	drug	drug	NN
cord-001835-0s7ok4uw	5705	8	resistance	resistance	NN
cord-001835-0s7ok4uw	5705	9	in	in	IN
cord-001835-0s7ok4uw	5705	10	protein	protein	NN
cord-001835-0s7ok4uw	5705	11	kinases	kinase	NNS
cord-001835-0s7ok4uw	5705	12	Marc	Marc	NNP
cord-001835-0s7ok4uw	5705	13	Hoemberger	Hoemberger	NNP
cord-001835-0s7ok4uw	5705	14	1	1	CD
cord-001835-0s7ok4uw	5705	15	,	,	,
cord-001835-0s7ok4uw	5705	16	Christopher	Christopher	NNP
cord-001835-0s7ok4uw	5705	17	Wilson	Wilson	NNP
cord-001835-0s7ok4uw	5705	18	1	1	CD
cord-001835-0s7ok4uw	5705	19	,	,	,
cord-001835-0s7ok4uw	5705	20	Roman	Roman	NNP
cord-001835-0s7ok4uw	5705	21	Agafonov	Agafonov	NNP
cord-001835-0s7ok4uw	5705	22	1	1	CD
cord-001835-0s7ok4uw	5705	23	,	,	,
cord-001835-0s7ok4uw	5705	24	Dorothee	Dorothee	NNP
cord-001835-0s7ok4uw	5705	25	Kern	Kern	NNP
cord-001835-0s7ok4uw	5705	26	1	1	CD
cord-001835-0s7ok4uw	5705	27	1	1	CD
cord-001835-0s7ok4uw	5706	1	The	the	DT
cord-001835-0s7ok4uw	5706	2	anti	anti	JJ
cord-001835-0s7ok4uw	5706	3	-	-	JJ
cord-001835-0s7ok4uw	5706	4	cancer	cancer	JJ
cord-001835-0s7ok4uw	5706	5	drug	drug	NN
cord-001835-0s7ok4uw	5706	6	imatinib	imatinib	RB
cord-001835-0s7ok4uw	5706	7	exhibits	exhibit	VBZ
cord-001835-0s7ok4uw	5706	8	highly	highly	RB
cord-001835-0s7ok4uw	5706	9	specific	specific	JJ
cord-001835-0s7ok4uw	5706	10	binding	binding	NN
cord-001835-0s7ok4uw	5706	11	to	to	IN
cord-001835-0s7ok4uw	5706	12	the	the	DT
cord-001835-0s7ok4uw	5706	13	human	human	JJ
cord-001835-0s7ok4uw	5706	14	kinase	kinase	NN
cord-001835-0s7ok4uw	5706	15	and	and	CC
cord-001835-0s7ok4uw	5706	16	oncogene	oncogene	NN
cord-001835-0s7ok4uw	5706	17	Abl	Abl	NNP
cord-001835-0s7ok4uw	5706	18	with	with	IN
cord-001835-0s7ok4uw	5706	19	a	a	DT
cord-001835-0s7ok4uw	5706	20	three	three	CD
cord-001835-0s7ok4uw	5706	21	thousand	thousand	CD
cord-001835-0s7ok4uw	5706	22	fold	fold	VB
cord-001835-0s7ok4uw	5706	23	weaker	weak	JJR
cord-001835-0s7ok4uw	5706	24	affinity	affinity	NN
cord-001835-0s7ok4uw	5706	25	for	for	IN
cord-001835-0s7ok4uw	5706	26	the	the	DT
cord-001835-0s7ok4uw	5706	27	structurally	structurally	RB
cord-001835-0s7ok4uw	5706	28	and	and	CC
cord-001835-0s7ok4uw	5706	29	functionally	functionally	RB
cord-001835-0s7ok4uw	5706	30	very	very	RB
cord-001835-0s7ok4uw	5706	31	similar	similar	JJ
cord-001835-0s7ok4uw	5706	32	kinase	kinase	NN
cord-001835-0s7ok4uw	5706	33	Src	Src	NNP
cord-001835-0s7ok4uw	5706	34	.	.	.
cord-001835-0s7ok4uw	5707	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5707	2	has	have	VBZ
cord-001835-0s7ok4uw	5707	3	been	be	VBN
cord-001835-0s7ok4uw	5707	4	shown	show	VBN
cord-001835-0s7ok4uw	5707	5	recently	recently	RB
cord-001835-0s7ok4uw	5707	6	that	that	IN
cord-001835-0s7ok4uw	5707	7	the	the	DT
cord-001835-0s7ok4uw	5707	8	major	major	JJ
cord-001835-0s7ok4uw	5707	9	difference	difference	NN
cord-001835-0s7ok4uw	5707	10	in	in	IN
cord-001835-0s7ok4uw	5707	11	binding	binding	NN
cord-001835-0s7ok4uw	5707	12	of	of	IN
cord-001835-0s7ok4uw	5707	13	imatinib	imatinib	NN
cord-001835-0s7ok4uw	5707	14	to	to	IN
cord-001835-0s7ok4uw	5707	15	Abl	Abl	NNP
cord-001835-0s7ok4uw	5707	16	and	and	CC
cord-001835-0s7ok4uw	5707	17	Src	Src	NNP
cord-001835-0s7ok4uw	5707	18	stems	stem	VBZ
cord-001835-0s7ok4uw	5707	19	from	from	IN
cord-001835-0s7ok4uw	5707	20	an	an	DT
cord-001835-0s7ok4uw	5707	21	induced	induce	VBN
cord-001835-0s7ok4uw	5707	22	fit	fit	JJ
cord-001835-0s7ok4uw	5707	23	after	after	IN
cord-001835-0s7ok4uw	5707	24	binding	bind	VBG
cord-001835-0s7ok4uw	5707	25	of	of	IN
cord-001835-0s7ok4uw	5707	26	the	the	DT
cord-001835-0s7ok4uw	5707	27	drug	drug	NN
cord-001835-0s7ok4uw	5707	28	.	.	.
cord-001835-0s7ok4uw	5708	1	To	to	TO
cord-001835-0s7ok4uw	5708	2	further	further	RB
cord-001835-0s7ok4uw	5708	3	understand	understand	VB
cord-001835-0s7ok4uw	5708	4	the	the	DT
cord-001835-0s7ok4uw	5708	5	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5708	6	of	of	IN
cord-001835-0s7ok4uw	5708	7	imatinib	imatinib	RB
cord-001835-0s7ok4uw	5708	8	binding	bind	VBG
cord-001835-0s7ok4uw	5708	9	to	to	IN
cord-001835-0s7ok4uw	5708	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5708	11	target	target	NN
cord-001835-0s7ok4uw	5708	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	5708	13	used	use	VBD
cord-001835-0s7ok4uw	5708	14	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	5708	15	sequence	sequence	NN
cord-001835-0s7ok4uw	5708	16	reconstruction	reconstruction	NN
cord-001835-0s7ok4uw	5708	17	(	(	-LRB-
cord-001835-0s7ok4uw	5708	18	ASR	ASR	NNP
cord-001835-0s7ok4uw	5708	19	)	)	-RRB-
cord-001835-0s7ok4uw	5708	20	and	and	CC
cord-001835-0s7ok4uw	5708	21	resurrected	resurrect	VBD
cord-001835-0s7ok4uw	5708	22	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5708	23	along	along	IN
cord-001835-0s7ok4uw	5708	24	the	the	DT
cord-001835-0s7ok4uw	5708	25	node	node	NN
cord-001835-0s7ok4uw	5708	26	from	from	IN
cord-001835-0s7ok4uw	5708	27	the	the	DT
cord-001835-0s7ok4uw	5708	28	common	common	JJ
cord-001835-0s7ok4uw	5708	29	ancestor	ancestor	NN
cord-001835-0s7ok4uw	5708	30	of	of	IN
cord-001835-0s7ok4uw	5708	31	Abl	Abl	NNP
cord-001835-0s7ok4uw	5708	32	and	and	CC
cord-001835-0s7ok4uw	5708	33	Src	Src	NNP
cord-001835-0s7ok4uw	5708	34	up	up	RP
cord-001835-0s7ok4uw	5708	35	to	to	IN
cord-001835-0s7ok4uw	5708	36	the	the	DT
cord-001835-0s7ok4uw	5708	37	extant	extant	JJ
cord-001835-0s7ok4uw	5708	38	kinases	kinase	NNS
cord-001835-0s7ok4uw	5708	39	.	.	.
cord-001835-0s7ok4uw	5709	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5709	2	show	show	VBP
cord-001835-0s7ok4uw	5709	3	that	that	IN
cord-001835-0s7ok4uw	5709	4	imatinib	imatinib	JJ
cord-001835-0s7ok4uw	5709	5	affinity	affinity	NN
cord-001835-0s7ok4uw	5709	6	is	be	VBZ
cord-001835-0s7ok4uw	5709	7	gained	gain	VBN
cord-001835-0s7ok4uw	5709	8	towards	towards	IN
cord-001835-0s7ok4uw	5709	9	the	the	DT
cord-001835-0s7ok4uw	5709	10	evolution	evolution	NN
cord-001835-0s7ok4uw	5709	11	of	of	IN
cord-001835-0s7ok4uw	5709	12	extant	extant	JJ
cord-001835-0s7ok4uw	5709	13	Abl	Abl	NNP
cord-001835-0s7ok4uw	5709	14	while	while	IN
cord-001835-0s7ok4uw	5709	15	it	-PRON-	PRP
cord-001835-0s7ok4uw	5709	16	is	be	VBZ
cord-001835-0s7ok4uw	5709	17	lost	lose	VBN
cord-001835-0s7ok4uw	5709	18	towards	towards	IN
cord-001835-0s7ok4uw	5709	19	evolving	evolve	VBG
cord-001835-0s7ok4uw	5709	20	Src	Src	NNP
cord-001835-0s7ok4uw	5709	21	.	.	.
cord-001835-0s7ok4uw	5710	1	The	the	DT
cord-001835-0s7ok4uw	5710	2	combination	combination	NN
cord-001835-0s7ok4uw	5710	3	of	of	IN
cord-001835-0s7ok4uw	5710	4	ASR	ASR	NNP
cord-001835-0s7ok4uw	5710	5	and	and	CC
cord-001835-0s7ok4uw	5710	6	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	5710	7	data	datum	NNS
cord-001835-0s7ok4uw	5710	8	of	of	IN
cord-001835-0s7ok4uw	5710	9	the	the	DT
cord-001835-0s7ok4uw	5710	10	ancestors	ancestor	NNS
cord-001835-0s7ok4uw	5710	11	in	in	IN
cord-001835-0s7ok4uw	5710	12	addition	addition	NN
cord-001835-0s7ok4uw	5710	13	to	to	IN
cord-001835-0s7ok4uw	5710	14	kinetics	kinetics	NNP
cord-001835-0s7ok4uw	5710	15	data	datum	NNS
cord-001835-0s7ok4uw	5710	16	allowed	allow	VBD
cord-001835-0s7ok4uw	5710	17	us	-PRON-	PRP
cord-001835-0s7ok4uw	5710	18	to	to	TO
cord-001835-0s7ok4uw	5710	19	identify	identify	VB
cord-001835-0s7ok4uw	5710	20	a	a	DT
cord-001835-0s7ok4uw	5710	21	subset	subset	NN
cord-001835-0s7ok4uw	5710	22	of	of	IN
cord-001835-0s7ok4uw	5710	23	residues	residue	NNS
cord-001835-0s7ok4uw	5710	24	involved	involve	VBN
cord-001835-0s7ok4uw	5710	25	in	in	IN
cord-001835-0s7ok4uw	5710	26	imatinib	imatinib	JJ
cord-001835-0s7ok4uw	5710	27	specificity	specificity	NN
cord-001835-0s7ok4uw	5710	28	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	5710	29	to	to	TO
cord-001835-0s7ok4uw	5710	30	switch	switch	VB
cord-001835-0s7ok4uw	5710	31	from	from	IN
cord-001835-0s7ok4uw	5710	32	an	an	DT
cord-001835-0s7ok4uw	5710	33	intermediate	intermediate	JJ
cord-001835-0s7ok4uw	5710	34	binder	binder	NN
cord-001835-0s7ok4uw	5710	35	to	to	IN
cord-001835-0s7ok4uw	5710	36	a	a	DT
cord-001835-0s7ok4uw	5710	37	tight	tight	JJ
cord-001835-0s7ok4uw	5710	38	binder	binder	NN
cord-001835-0s7ok4uw	5710	39	.	.	.
cord-001835-0s7ok4uw	5711	1	Preliminary	preliminary	JJ
cord-001835-0s7ok4uw	5711	2	data	data	NN
cord-001835-0s7ok4uw	5711	3	shows	show	VBZ
cord-001835-0s7ok4uw	5711	4	that	that	IN
cord-001835-0s7ok4uw	5711	5	a	a	DT
cord-001835-0s7ok4uw	5711	6	network	network	NN
cord-001835-0s7ok4uw	5711	7	of	of	IN
cord-001835-0s7ok4uw	5711	8	hydrogen	hydrogen	NN
cord-001835-0s7ok4uw	5711	9	bonds	bond	NNS
cord-001835-0s7ok4uw	5711	10	and	and	CC
cord-001835-0s7ok4uw	5711	11	packing	packing	NN
cord-001835-0s7ok4uw	5711	12	interactions	interaction	NNS
cord-001835-0s7ok4uw	5711	13	stabilize	stabilize	VBP
cord-001835-0s7ok4uw	5711	14	the	the	DT
cord-001835-0s7ok4uw	5711	15	kinked	kinked	JJ
cord-001835-0s7ok4uw	5711	16	p	p	NN
cord-001835-0s7ok4uw	5711	17	-	-	HYPH
cord-001835-0s7ok4uw	5711	18	loop	loop	NN
cord-001835-0s7ok4uw	5711	19	conformation	conformation	NN
cord-001835-0s7ok4uw	5711	20	for	for	IN
cord-001835-0s7ok4uw	5711	21	tight	tight	JJ
cord-001835-0s7ok4uw	5711	22	binders	binder	NNS
cord-001835-0s7ok4uw	5711	23	thus	thus	RB
cord-001835-0s7ok4uw	5711	24	allowing	allow	VBG
cord-001835-0s7ok4uw	5711	25	for	for	IN
cord-001835-0s7ok4uw	5711	26	more	more	JJR
cord-001835-0s7ok4uw	5711	27	interactions	interaction	NNS
cord-001835-0s7ok4uw	5711	28	between	between	IN
cord-001835-0s7ok4uw	5711	29	the	the	DT
cord-001835-0s7ok4uw	5711	30	kinase	kinase	NN
cord-001835-0s7ok4uw	5711	31	and	and	CC
cord-001835-0s7ok4uw	5711	32	the	the	DT
cord-001835-0s7ok4uw	5711	33	drug	drug	NN
cord-001835-0s7ok4uw	5711	34	.	.	.
cord-001835-0s7ok4uw	5712	1	Strikingly	strikingly	RB
cord-001835-0s7ok4uw	5712	2	,	,	,
cord-001835-0s7ok4uw	5712	3	many	many	JJ
cord-001835-0s7ok4uw	5712	4	of	of	IN
cord-001835-0s7ok4uw	5712	5	these	these	DT
cord-001835-0s7ok4uw	5712	6	residues	residue	NNS
cord-001835-0s7ok4uw	5712	7	were	be	VBD
cord-001835-0s7ok4uw	5712	8	identified	identify	VBN
cord-001835-0s7ok4uw	5712	9	in	in	IN
cord-001835-0s7ok4uw	5712	10	human	human	JJ
cord-001835-0s7ok4uw	5712	11	cancer	cancer	NN
cord-001835-0s7ok4uw	5712	12	patients	patient	NNS
cord-001835-0s7ok4uw	5712	13	as	as	IN
cord-001835-0s7ok4uw	5712	14	"	"	``
cord-001835-0s7ok4uw	5712	15	hot	hot	JJ
cord-001835-0s7ok4uw	5712	16	spots	spot	NNS
cord-001835-0s7ok4uw	5712	17	"	"	''
cord-001835-0s7ok4uw	5712	18	for	for	IN
cord-001835-0s7ok4uw	5712	19	the	the	DT
cord-001835-0s7ok4uw	5712	20	development	development	NN
cord-001835-0s7ok4uw	5712	21	of	of	IN
cord-001835-0s7ok4uw	5712	22	resistance	resistance	NN
cord-001835-0s7ok4uw	5712	23	mutations	mutation	NNS
cord-001835-0s7ok4uw	5712	24	.	.	.
cord-001835-0s7ok4uw	5713	1	Further	further	JJ
cord-001835-0s7ok4uw	5713	2	investigation	investigation	NN
cord-001835-0s7ok4uw	5713	3	into	into	IN
cord-001835-0s7ok4uw	5713	4	the	the	DT
cord-001835-0s7ok4uw	5713	5	identified	identify	VBN
cord-001835-0s7ok4uw	5713	6	subset	subset	NN
cord-001835-0s7ok4uw	5713	7	of	of	IN
cord-001835-0s7ok4uw	5713	8	residues	residue	NNS
cord-001835-0s7ok4uw	5713	9	in	in	IN
cord-001835-0s7ok4uw	5713	10	combination	combination	NN
cord-001835-0s7ok4uw	5713	11	with	with	IN
cord-001835-0s7ok4uw	5713	12	these	these	DT
cord-001835-0s7ok4uw	5713	13	commonly	commonly	RB
cord-001835-0s7ok4uw	5713	14	found	find	VBN
cord-001835-0s7ok4uw	5713	15	imatinib	imatinib	JJ
cord-001835-0s7ok4uw	5713	16	resistance	resistance	NN
cord-001835-0s7ok4uw	5713	17	mutations	mutation	NNS
cord-001835-0s7ok4uw	5713	18	will	will	MD
cord-001835-0s7ok4uw	5713	19	allow	allow	VB
cord-001835-0s7ok4uw	5713	20	us	-PRON-	PRP
cord-001835-0s7ok4uw	5713	21	to	to	TO
cord-001835-0s7ok4uw	5713	22	understand	understand	VB
cord-001835-0s7ok4uw	5713	23	emerging	emerge	VBG
cord-001835-0s7ok4uw	5713	24	drug	drug	NN
cord-001835-0s7ok4uw	5713	25	resistances	resistance	NNS
cord-001835-0s7ok4uw	5713	26	better	well	RBR
cord-001835-0s7ok4uw	5713	27	.	.	.
cord-001835-0s7ok4uw	5714	1	An	an	DT
cord-001835-0s7ok4uw	5714	2	evolutionary	evolutionary	JJ
cord-001835-0s7ok4uw	5714	3	view	view	NN
cord-001835-0s7ok4uw	5714	4	of	of	IN
cord-001835-0s7ok4uw	5714	5	the	the	DT
cord-001835-0s7ok4uw	5714	6	cold	cold	JJ
cord-001835-0s7ok4uw	5714	7	adapted	adapt	VBN
cord-001835-0s7ok4uw	5714	8	catalysis	catalysis	NN
cord-001835-0s7ok4uw	5714	9	of	of	IN
cord-001835-0s7ok4uw	5714	10	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5714	11	Vy	Vy	NNP
cord-001835-0s7ok4uw	5714	12	Nguyen	Nguyen	NNP
cord-001835-0s7ok4uw	5714	13	1	1	CD
cord-001835-0s7ok4uw	5714	14	,	,	,
cord-001835-0s7ok4uw	5714	15	Christopher	Christopher	NNP
cord-001835-0s7ok4uw	5714	16	Wilson	Wilson	NNP
cord-001835-0s7ok4uw	5714	17	1	1	CD
cord-001835-0s7ok4uw	5714	18	,	,	,
cord-001835-0s7ok4uw	5714	19	Dorothee	Dorothee	NNP
cord-001835-0s7ok4uw	5714	20	Kern	Kern	NNP
cord-001835-0s7ok4uw	5714	21	1	1	CD
cord-001835-0s7ok4uw	5714	22	1	1	CD
cord-001835-0s7ok4uw	5715	1	The	the	DT
cord-001835-0s7ok4uw	5715	2	diversity	diversity	NN
cord-001835-0s7ok4uw	5715	3	in	in	IN
cord-001835-0s7ok4uw	5715	4	protein	protein	NN
cord-001835-0s7ok4uw	5715	5	function	function	NN
cord-001835-0s7ok4uw	5715	6	that	that	WDT
cord-001835-0s7ok4uw	5715	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	5715	8	see	see	VBP
cord-001835-0s7ok4uw	5715	9	today	today	NN
cord-001835-0s7ok4uw	5715	10	arose	arise	VBD
cord-001835-0s7ok4uw	5715	11	as	as	IN
cord-001835-0s7ok4uw	5715	12	a	a	DT
cord-001835-0s7ok4uw	5715	13	result	result	NN
cord-001835-0s7ok4uw	5715	14	of	of	IN
cord-001835-0s7ok4uw	5715	15	life	life	NN
cord-001835-0s7ok4uw	5715	16	adapting	adapt	VBG
cord-001835-0s7ok4uw	5715	17	to	to	IN
cord-001835-0s7ok4uw	5715	18	a	a	DT
cord-001835-0s7ok4uw	5715	19	cooling	cool	VBG
cord-001835-0s7ok4uw	5715	20	earth	earth	NN
cord-001835-0s7ok4uw	5715	21	.	.	.
cord-001835-0s7ok4uw	5716	1	How	how	WRB
cord-001835-0s7ok4uw	5716	2	did	do	VBD
cord-001835-0s7ok4uw	5716	3	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5716	4	,	,	,
cord-001835-0s7ok4uw	5716	5	the	the	DT
cord-001835-0s7ok4uw	5716	6	catalysts	catalyst	NNS
cord-001835-0s7ok4uw	5716	7	of	of	IN
cord-001835-0s7ok4uw	5716	8	many	many	JJ
cord-001835-0s7ok4uw	5716	9	crucial	crucial	JJ
cord-001835-0s7ok4uw	5716	10	cellular	cellular	JJ
cord-001835-0s7ok4uw	5716	11	processes	process	NNS
cord-001835-0s7ok4uw	5716	12	,	,	,
cord-001835-0s7ok4uw	5716	13	achieve	achieve	VB
cord-001835-0s7ok4uw	5716	14	this	this	DT
cord-001835-0s7ok4uw	5716	15	cold	cold	JJ
cord-001835-0s7ok4uw	5716	16	adaptation	adaptation	NN
cord-001835-0s7ok4uw	5716	17	?	?	.
cord-001835-0s7ok4uw	5717	1	This	this	DT
cord-001835-0s7ok4uw	5717	2	is	be	VBZ
cord-001835-0s7ok4uw	5717	3	a	a	DT
cord-001835-0s7ok4uw	5717	4	challenging	challenging	JJ
cord-001835-0s7ok4uw	5717	5	question	question	NN
cord-001835-0s7ok4uw	5717	6	to	to	TO
cord-001835-0s7ok4uw	5717	7	answer	answer	VB
cord-001835-0s7ok4uw	5717	8	because	because	IN
cord-001835-0s7ok4uw	5717	9	ancient	ancient	JJ
cord-001835-0s7ok4uw	5717	10	sequences	sequence	NNS
cord-001835-0s7ok4uw	5717	11	of	of	IN
cord-001835-0s7ok4uw	5717	12	proteins	protein	NNS
cord-001835-0s7ok4uw	5717	13	that	that	WDT
cord-001835-0s7ok4uw	5717	14	existed	exist	VBD
cord-001835-0s7ok4uw	5717	15	billions	billion	NNS
cord-001835-0s7ok4uw	5717	16	of	of	IN
cord-001835-0s7ok4uw	5717	17	years	year	NNS
cord-001835-0s7ok4uw	5717	18	ago	ago	RB
cord-001835-0s7ok4uw	5717	19	are	be	VBP
cord-001835-0s7ok4uw	5717	20	not	not	RB
cord-001835-0s7ok4uw	5717	21	available	available	JJ
cord-001835-0s7ok4uw	5717	22	.	.	.
cord-001835-0s7ok4uw	5718	1	To	to	TO
cord-001835-0s7ok4uw	5718	2	address	address	VB
cord-001835-0s7ok4uw	5718	3	this	this	DT
cord-001835-0s7ok4uw	5718	4	question	question	NN
cord-001835-0s7ok4uw	5718	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	5718	6	used	use	VBD
cord-001835-0s7ok4uw	5718	7	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	5718	8	sequence	sequence	NN
cord-001835-0s7ok4uw	5718	9	reconstruction	reconstruction	NN
cord-001835-0s7ok4uw	5718	10	to	to	TO
cord-001835-0s7ok4uw	5718	11	create	create	VB
cord-001835-0s7ok4uw	5718	12	adenylate	adenylate	NN
cord-001835-0s7ok4uw	5718	13	kinase	kinase	NN
cord-001835-0s7ok4uw	5718	14	(	(	-LRB-
cord-001835-0s7ok4uw	5718	15	Adk	adk	NN
cord-001835-0s7ok4uw	5718	16	)	)	-RRB-
cord-001835-0s7ok4uw	5718	17	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5718	18	from	from	IN
cord-001835-0s7ok4uw	5718	19	the	the	DT
cord-001835-0s7ok4uw	5718	20	divergence	divergence	NN
cord-001835-0s7ok4uw	5718	21	of	of	IN
cord-001835-0s7ok4uw	5718	22	Anaerobic	Anaerobic	NNP
cord-001835-0s7ok4uw	5718	23	and	and	CC
cord-001835-0s7ok4uw	5718	24	Aerobic	Aerobic	NNP
cord-001835-0s7ok4uw	5718	25	Firmicutes	Firmicutes	NNPS
cord-001835-0s7ok4uw	5718	26	towards	towards	IN
cord-001835-0s7ok4uw	5718	27	modern	modern	JJ
cord-001835-0s7ok4uw	5718	28	day	day	NN
cord-001835-0s7ok4uw	5718	29	thermophilic	thermophilic	JJ
cord-001835-0s7ok4uw	5718	30	,	,	,
cord-001835-0s7ok4uw	5718	31	mesophilic	mesophilic	JJ
cord-001835-0s7ok4uw	5718	32	and	and	CC
cord-001835-0s7ok4uw	5718	33	psychrophilic	psychrophilic	JJ
cord-001835-0s7ok4uw	5718	34	organisms	organism	NNS
cord-001835-0s7ok4uw	5718	35	.	.	.
cord-001835-0s7ok4uw	5719	1	Adk	adk	NN
cord-001835-0s7ok4uw	5719	2	is	be	VBZ
cord-001835-0s7ok4uw	5719	3	a	a	DT
cord-001835-0s7ok4uw	5719	4	phosphotransferase	phosphotransferase	NN
cord-001835-0s7ok4uw	5719	5	that	that	WDT
cord-001835-0s7ok4uw	5719	6	catalyzes	catalyze	VBZ
cord-001835-0s7ok4uw	5719	7	the	the	DT
cord-001835-0s7ok4uw	5719	8	conversion	conversion	NN
cord-001835-0s7ok4uw	5719	9	of	of	IN
cord-001835-0s7ok4uw	5719	10	two	two	CD
cord-001835-0s7ok4uw	5719	11	ADP	ADP	NNP
cord-001835-0s7ok4uw	5719	12	molecules	molecule	NNS
cord-001835-0s7ok4uw	5719	13	into	into	IN
cord-001835-0s7ok4uw	5719	14	ATP	ATP	NNP
cord-001835-0s7ok4uw	5719	15	and	and	CC
cord-001835-0s7ok4uw	5719	16	AMP	AMP	NNP
cord-001835-0s7ok4uw	5719	17	.	.	.
cord-001835-0s7ok4uw	5720	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5720	2	make	make	VBP
cord-001835-0s7ok4uw	5720	3	the	the	DT
cord-001835-0s7ok4uw	5720	4	following	follow	VBG
cord-001835-0s7ok4uw	5720	5	observations	observation	NNS
cord-001835-0s7ok4uw	5720	6	.	.	.
cord-001835-0s7ok4uw	5721	1	First	first	RB
cord-001835-0s7ok4uw	5721	2	,	,	,
cord-001835-0s7ok4uw	5721	3	all	all	DT
cord-001835-0s7ok4uw	5721	4	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	5721	5	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5721	6	are	be	VBP
cord-001835-0s7ok4uw	5721	7	active	active	JJ
cord-001835-0s7ok4uw	5721	8	with	with	IN
cord-001835-0s7ok4uw	5721	9	optimal	optimal	JJ
cord-001835-0s7ok4uw	5721	10	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5721	11	rates	rate	NNS
cord-001835-0s7ok4uw	5721	12	linearly	linearly	RB
cord-001835-0s7ok4uw	5721	13	corresponding	correspond	VBG
cord-001835-0s7ok4uw	5721	14	to	to	IN
cord-001835-0s7ok4uw	5721	15	the	the	DT
cord-001835-0s7ok4uw	5721	16	temperature	temperature	NN
cord-001835-0s7ok4uw	5721	17	of	of	IN
cord-001835-0s7ok4uw	5721	18	the	the	DT
cord-001835-0s7ok4uw	5721	19	environments	environment	NNS
cord-001835-0s7ok4uw	5721	20	where	where	WRB
cord-001835-0s7ok4uw	5721	21	these	these	DT
cord-001835-0s7ok4uw	5721	22	proteins	protein	NNS
cord-001835-0s7ok4uw	5721	23	would	would	MD
cord-001835-0s7ok4uw	5721	24	have	have	VB
cord-001835-0s7ok4uw	5721	25	been	be	VBN
cord-001835-0s7ok4uw	5721	26	found	find	VBN
cord-001835-0s7ok4uw	5721	27	.	.	.
cord-001835-0s7ok4uw	5722	1	Most	most	RBS
cord-001835-0s7ok4uw	5722	2	strikingly	strikingly	RB
cord-001835-0s7ok4uw	5722	3	,	,	,
cord-001835-0s7ok4uw	5722	4	the	the	DT
cord-001835-0s7ok4uw	5722	5	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5722	6	rate	rate	NN
cord-001835-0s7ok4uw	5722	7	of	of	IN
cord-001835-0s7ok4uw	5722	8	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5722	9	oldest	old	JJS
cord-001835-0s7ok4uw	5722	10	Adk	Adk	NNP
cord-001835-0s7ok4uw	5722	11	ancestor	ancestor	NN
cord-001835-0s7ok4uw	5722	12	exhibits	exhibit	VBZ
cord-001835-0s7ok4uw	5722	13	a	a	DT
cord-001835-0s7ok4uw	5722	14	higher	high	JJR
cord-001835-0s7ok4uw	5722	15	enthalpy	enthalpy	NN
cord-001835-0s7ok4uw	5722	16	of	of	IN
cord-001835-0s7ok4uw	5722	17	activation	activation	NN
cord-001835-0s7ok4uw	5722	18	at	at	IN
cord-001835-0s7ok4uw	5722	19	low	low	JJ
cord-001835-0s7ok4uw	5722	20	temperatures	temperature	NNS
cord-001835-0s7ok4uw	5722	21	as	as	IN
cord-001835-0s7ok4uw	5722	22	compared	compare	VBN
cord-001835-0s7ok4uw	5722	23	to	to	IN
cord-001835-0s7ok4uw	5722	24	the	the	DT
cord-001835-0s7ok4uw	5722	25	modern	modern	JJ
cord-001835-0s7ok4uw	5722	26	thermophilic	thermophilic	JJ
cord-001835-0s7ok4uw	5722	27	Adk	adk	NN
cord-001835-0s7ok4uw	5722	28	.	.	.
cord-001835-0s7ok4uw	5723	1	This	this	DT
cord-001835-0s7ok4uw	5723	2	suggests	suggest	VBZ
cord-001835-0s7ok4uw	5723	3	a	a	DT
cord-001835-0s7ok4uw	5723	4	large	large	JJ
cord-001835-0s7ok4uw	5723	5	enthalpic	enthalpic	JJ
cord-001835-0s7ok4uw	5723	6	penalty	penalty	NN
cord-001835-0s7ok4uw	5723	7	had	have	VBD
cord-001835-0s7ok4uw	5723	8	to	to	TO
cord-001835-0s7ok4uw	5723	9	be	be	VB
cord-001835-0s7ok4uw	5723	10	paid	pay	VBN
cord-001835-0s7ok4uw	5723	11	for	for	IN
cord-001835-0s7ok4uw	5723	12	reactions	reaction	NNS
cord-001835-0s7ok4uw	5723	13	to	to	TO
cord-001835-0s7ok4uw	5723	14	occur	occur	VB
cord-001835-0s7ok4uw	5723	15	at	at	IN
cord-001835-0s7ok4uw	5723	16	cold	cold	JJ
cord-001835-0s7ok4uw	5723	17	temperatures	temperature	NNS
cord-001835-0s7ok4uw	5723	18	in	in	IN
cord-001835-0s7ok4uw	5723	19	an	an	DT
cord-001835-0s7ok4uw	5723	20	ancestor	ancestor	NN
cord-001835-0s7ok4uw	5723	21	that	that	WDT
cord-001835-0s7ok4uw	5723	22	existed	exist	VBD
cord-001835-0s7ok4uw	5723	23	in	in	IN
cord-001835-0s7ok4uw	5723	24	a	a	DT
cord-001835-0s7ok4uw	5723	25	hot	hot	JJ
cord-001835-0s7ok4uw	5723	26	environment	environment	NN
cord-001835-0s7ok4uw	5723	27	.	.	.
cord-001835-0s7ok4uw	5724	1	Second	second	RB
cord-001835-0s7ok4uw	5724	2	,	,	,
cord-001835-0s7ok4uw	5724	3	several	several	JJ
cord-001835-0s7ok4uw	5724	4	high	high	JJ
cord-001835-0s7ok4uw	5724	5	resolution	resolution	NN
cord-001835-0s7ok4uw	5724	6	crystal	crystal	NN
cord-001835-0s7ok4uw	5724	7	structures	structure	NNS
cord-001835-0s7ok4uw	5724	8	of	of	IN
cord-001835-0s7ok4uw	5724	9	extant	extant	JJ
cord-001835-0s7ok4uw	5724	10	proteins	protein	NNS
cord-001835-0s7ok4uw	5724	11	that	that	WDT
cord-001835-0s7ok4uw	5724	12	we	-PRON-	PRP
cord-001835-0s7ok4uw	5724	13	solved	solve	VBD
cord-001835-0s7ok4uw	5724	14	(	(	-LRB-
cord-001835-0s7ok4uw	5724	15	1.2Å	1.2Å	NNP
cord-001835-0s7ok4uw	5724	16	-1.6Å	-1.6Å	NNP
cord-001835-0s7ok4uw	5724	17	)	)	-RRB-
cord-001835-0s7ok4uw	5724	18	,	,	,
cord-001835-0s7ok4uw	5724	19	show	show	VBP
cord-001835-0s7ok4uw	5724	20	that	that	IN
cord-001835-0s7ok4uw	5724	21	the	the	DT
cord-001835-0s7ok4uw	5724	22	oldest	old	JJS
cord-001835-0s7ok4uw	5724	23	ancestors	ancestor	NNS
cord-001835-0s7ok4uw	5724	24	were	be	VBD
cord-001835-0s7ok4uw	5724	25	more	more	RBR
cord-001835-0s7ok4uw	5724	26	rigid	rigid	JJ
cord-001835-0s7ok4uw	5724	27	than	than	IN
cord-001835-0s7ok4uw	5724	28	the	the	DT
cord-001835-0s7ok4uw	5724	29	modern	modern	JJ
cord-001835-0s7ok4uw	5724	30	Adks	Adks	NNP
cord-001835-0s7ok4uw	5724	31	due	due	IN
cord-001835-0s7ok4uw	5724	32	to	to	IN
cord-001835-0s7ok4uw	5724	33	an	an	DT
cord-001835-0s7ok4uw	5724	34	intricate	intricate	JJ
cord-001835-0s7ok4uw	5724	35	salt	salt	NN
cord-001835-0s7ok4uw	5724	36	-	-	HYPH
cord-001835-0s7ok4uw	5724	37	bridge	bridge	NN
cord-001835-0s7ok4uw	5724	38	network	network	NN
cord-001835-0s7ok4uw	5724	39	.	.	.
cord-001835-0s7ok4uw	5725	1	This	this	DT
cord-001835-0s7ok4uw	5725	2	work	work	NN
cord-001835-0s7ok4uw	5725	3	,	,	,
cord-001835-0s7ok4uw	5725	4	thus	thus	RB
cord-001835-0s7ok4uw	5725	5	shows	show	VBZ
cord-001835-0s7ok4uw	5725	6	for	for	IN
cord-001835-0s7ok4uw	5725	7	the	the	DT
cord-001835-0s7ok4uw	5725	8	first	first	JJ
cord-001835-0s7ok4uw	5725	9	time	time	NN
cord-001835-0s7ok4uw	5725	10	,	,	,
cord-001835-0s7ok4uw	5725	11	the	the	DT
cord-001835-0s7ok4uw	5725	12	molecular	molecular	JJ
cord-001835-0s7ok4uw	5725	13	and	and	CC
cord-001835-0s7ok4uw	5725	14	thermodynamic	thermodynamic	JJ
cord-001835-0s7ok4uw	5725	15	determinants	determinant	NNS
cord-001835-0s7ok4uw	5725	16	of	of	IN
cord-001835-0s7ok4uw	5725	17	cold	cold	JJ
cord-001835-0s7ok4uw	5725	18	adaptation	adaptation	NN
cord-001835-0s7ok4uw	5725	19	in	in	IN
cord-001835-0s7ok4uw	5725	20	an	an	DT
cord-001835-0s7ok4uw	5725	21	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5725	22	over	over	IN
cord-001835-0s7ok4uw	5725	23	a	a	DT
cord-001835-0s7ok4uw	5725	24	time	time	NN
cord-001835-0s7ok4uw	5725	25	period	period	NN
cord-001835-0s7ok4uw	5725	26	that	that	WDT
cord-001835-0s7ok4uw	5725	27	spans	span	VBZ
cord-001835-0s7ok4uw	5725	28	billions	billion	NNS
cord-001835-0s7ok4uw	5725	29	of	of	IN
cord-001835-0s7ok4uw	5725	30	years	year	NNS
cord-001835-0s7ok4uw	5725	31	.	.	.
cord-001835-0s7ok4uw	5726	1	Induced	induce	VBN
cord-001835-0s7ok4uw	5726	2	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	5726	3	modification	modification	NN
cord-001835-0s7ok4uw	5726	4	of	of	IN
cord-001835-0s7ok4uw	5726	5	plasma	plasma	NN
cord-001835-0s7ok4uw	5726	6	and	and	CC
cord-001835-0s7ok4uw	5726	7	cellular	cellular	JJ
cord-001835-0s7ok4uw	5726	8	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5726	9	-	-	HYPH
cord-001835-0s7ok4uw	5726	10	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	5726	11	factor	factor	NN
cord-001835-0s7ok4uw	5726	12	Anna	Anna	NNP
cord-001835-0s7ok4uw	5726	13	Bychkova	Bychkova	NNP
cord-001835-0s7ok4uw	5726	14	1	1	CD
cord-001835-0s7ok4uw	5726	15	,	,	,
cord-001835-0s7ok4uw	5726	16	Tatiana	Tatiana	NNP
cord-001835-0s7ok4uw	5726	17	Danilova	Danilova	NNP
cord-001835-0s7ok4uw	5726	18	1	1	CD
cord-001835-0s7ok4uw	5726	19	,	,	,
cord-001835-0s7ok4uw	5726	20	Alexander	Alexander	NNP
cord-001835-0s7ok4uw	5726	21	Shchegolikhin	Shchegolikhin	NNP
cord-001835-0s7ok4uw	5726	22	1	1	CD
cord-001835-0s7ok4uw	5726	23	,	,	,
cord-001835-0s7ok4uw	5726	24	Vera	Vera	NNP
cord-001835-0s7ok4uw	5726	25	Leonova	Leonova	NNP
cord-001835-0s7ok4uw	5726	26	1	1	CD
cord-001835-0s7ok4uw	5726	27	,	,	,
cord-001835-0s7ok4uw	5726	28	Marina	Marina	NNP
cord-001835-0s7ok4uw	5726	29	Biryukova	Biryukova	NNP
cord-001835-0s7ok4uw	5726	30	1	1	CD
cord-001835-0s7ok4uw	5726	31	,	,	,
cord-001835-0s7ok4uw	5726	32	Elizaveta	Elizaveta	NNP
cord-001835-0s7ok4uw	5726	33	Kostanova	Kostanova	NNP
cord-001835-0s7ok4uw	5726	34	1	1	CD
cord-001835-0s7ok4uw	5726	35	,	,	,
cord-001835-0s7ok4uw	5726	36	Alexey	Alexey	NNP
cord-001835-0s7ok4uw	5726	37	Kononikhin	Kononikhin	NNP
cord-001835-0s7ok4uw	5726	38	0	0	NNP
cord-001835-0s7ok4uw	5726	39	,	,	,
cord-001835-0s7ok4uw	5726	40	Anna	Anna	NNP
cord-001835-0s7ok4uw	5726	41	Bugrova	Bugrova	NNP
cord-001835-0s7ok4uw	5726	42	1	1	CD
cord-001835-0s7ok4uw	5726	43	,	,	,
cord-001835-0s7ok4uw	5727	1	Evgeny	Evgeny	NNP
cord-001835-0s7ok4uw	5727	2	Nikolaev	Nikolaev	NNP
cord-001835-0s7ok4uw	5727	3	0	0	NNP
cord-001835-0s7ok4uw	5727	4	,	,	,
cord-001835-0s7ok4uw	5727	5	Mark	Mark	NNP
cord-001835-0s7ok4uw	5727	6	Rosenfeld	Rosenfeld	NNP
cord-001835-0s7ok4uw	5727	7	1	1	CD
cord-001835-0s7ok4uw	5727	8	1	1	CD
cord-001835-0s7ok4uw	5727	9	N.	N.	NNP
cord-001835-0s7ok4uw	5727	10	M.	M.	NNP
cord-001835-0s7ok4uw	5727	11	Emanuel	Emanuel	NNP
cord-001835-0s7ok4uw	5727	12	Institute	Institute	NNP
cord-001835-0s7ok4uw	5727	13	of	of	IN
cord-001835-0s7ok4uw	5727	14	Biochemical	Biochemical	NNP
cord-001835-0s7ok4uw	5727	15	Physics	Physics	NNP
cord-001835-0s7ok4uw	5727	16	,	,	,
cord-001835-0s7ok4uw	5727	17	Russian	Russian	NNP
cord-001835-0s7ok4uw	5727	18	Academy	Academy	NNP
cord-001835-0s7ok4uw	5727	19	of	of	IN
cord-001835-0s7ok4uw	5727	20	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	5727	21	,	,	,
cord-001835-0s7ok4uw	5727	22	2	2	CD
cord-001835-0s7ok4uw	5727	23	Institute	Institute	NNP
cord-001835-0s7ok4uw	5727	24	for	for	IN
cord-001835-0s7ok4uw	5727	25	Energy	Energy	NNP
cord-001835-0s7ok4uw	5727	26	Problems	Problems	NNPS
cord-001835-0s7ok4uw	5727	27	of	of	IN
cord-001835-0s7ok4uw	5727	28	Chemical	Chemical	NNP
cord-001835-0s7ok4uw	5727	29	Physics	Physics	NNP
cord-001835-0s7ok4uw	5727	30	,	,	,
cord-001835-0s7ok4uw	5727	31	Russian	Russian	NNP
cord-001835-0s7ok4uw	5727	32	Academy	Academy	NNP
cord-001835-0s7ok4uw	5727	33	of	of	IN
cord-001835-0s7ok4uw	5727	34	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	5728	1	The	the	DT
cord-001835-0s7ok4uw	5728	2	main	main	JJ
cord-001835-0s7ok4uw	5728	3	function	function	NN
cord-001835-0s7ok4uw	5728	4	of	of	IN
cord-001835-0s7ok4uw	5728	5	plasma	plasma	NN
cord-001835-0s7ok4uw	5728	6	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5728	7	-	-	HYPH
cord-001835-0s7ok4uw	5728	8	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	5728	9	factor	factor	NN
cord-001835-0s7ok4uw	5728	10	pFXIII	pfxiii	NN
cord-001835-0s7ok4uw	5728	11	is	be	VBZ
cord-001835-0s7ok4uw	5728	12	to	to	TO
cord-001835-0s7ok4uw	5728	13	catalyze	catalyze	VB
cord-001835-0s7ok4uw	5728	14	the	the	DT
cord-001835-0s7ok4uw	5728	15	formation	formation	NN
cord-001835-0s7ok4uw	5728	16	of	of	IN
cord-001835-0s7ok4uw	5728	17	the	the	DT
cord-001835-0s7ok4uw	5728	18	intermolecular	intermolecular	NNP
cord-001835-0s7ok4uw	5728	19	covalent	covalent	JJ
cord-001835-0s7ok4uw	5728	20	cross	cross	NN
cord-001835-0s7ok4uw	5728	21	-	-	NN
cord-001835-0s7ok4uw	5728	22	links	link	NNS
cord-001835-0s7ok4uw	5728	23	between	between	IN
cord-001835-0s7ok4uw	5728	24	both	both	DT
cord-001835-0s7ok4uw	5728	25	gand	gand	NNP
cord-001835-0s7ok4uw	5728	26	afibrin	afibrin	NNP
cord-001835-0s7ok4uw	5728	27	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	5728	28	chains	chain	NNS
cord-001835-0s7ok4uw	5728	29	.	.	.
cord-001835-0s7ok4uw	5729	1	The	the	DT
cord-001835-0s7ok4uw	5729	2	crosslinking	crosslinking	NN
cord-001835-0s7ok4uw	5729	3	crucially	crucially	RB
cord-001835-0s7ok4uw	5729	4	affects	affect	VBZ
cord-001835-0s7ok4uw	5729	5	mechanical	mechanical	JJ
cord-001835-0s7ok4uw	5729	6	strength	strength	NN
cord-001835-0s7ok4uw	5729	7	of	of	IN
cord-001835-0s7ok4uw	5729	8	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5729	9	and	and	CC
cord-001835-0s7ok4uw	5729	10	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5729	11	resistance	resistance	NN
cord-001835-0s7ok4uw	5729	12	against	against	IN
cord-001835-0s7ok4uw	5729	13	fibrinolysis	fibrinolysis	NNP
cord-001835-0s7ok4uw	5729	14	.	.	.
cord-001835-0s7ok4uw	5730	1	The	the	DT
cord-001835-0s7ok4uw	5730	2	precise	precise	JJ
cord-001835-0s7ok4uw	5730	3	role	role	NN
cord-001835-0s7ok4uw	5730	4	of	of	IN
cord-001835-0s7ok4uw	5730	5	cellular	cellular	JJ
cord-001835-0s7ok4uw	5730	6	fibrin	fibrin	NN
cord-001835-0s7ok4uw	5730	7	-	-	HYPH
cord-001835-0s7ok4uw	5730	8	stabilizing	stabilize	VBG
cord-001835-0s7ok4uw	5730	9	factor	factor	NN
cord-001835-0s7ok4uw	5730	10	cFXIII	cFXIII	NNP
cord-001835-0s7ok4uw	5730	11	remains	remain	VBZ
cord-001835-0s7ok4uw	5730	12	poorly	poorly	RB
cord-001835-0s7ok4uw	5730	13	understood	understand	VBN
cord-001835-0s7ok4uw	5730	14	.	.	.
cord-001835-0s7ok4uw	5731	1	pFXIII	pFXIII	NNP
cord-001835-0s7ok4uw	5731	2	is	be	VBZ
cord-001835-0s7ok4uw	5731	3	a	a	DT
cord-001835-0s7ok4uw	5731	4	heterotetramer	heterotetramer	NN
cord-001835-0s7ok4uw	5731	5	(	(	-LRB-
cord-001835-0s7ok4uw	5731	6	FXIII	FXIII	NNP
cord-001835-0s7ok4uw	5731	7	-	-	HYPH
cord-001835-0s7ok4uw	5731	8	A2B2	A2B2	NNP
cord-001835-0s7ok4uw	5731	9	)	)	-RRB-
cord-001835-0s7ok4uw	5731	10	consisting	consist	VBG
cord-001835-0s7ok4uw	5731	11	of	of	IN
cord-001835-0s7ok4uw	5731	12	two	two	CD
cord-001835-0s7ok4uw	5731	13	single	single	RB
cord-001835-0s7ok4uw	5731	14	-	-	HYPH
cord-001835-0s7ok4uw	5731	15	stranded	strand	VBN
cord-001835-0s7ok4uw	5731	16	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5731	17	A	A	NNP
cord-001835-0s7ok4uw	5731	18	subunits	subunit	NNS
cord-001835-0s7ok4uw	5731	19	(	(	-LRB-
cord-001835-0s7ok4uw	5731	20	FXIII	FXIII	NNP
cord-001835-0s7ok4uw	5731	21	-	-	HYPH
cord-001835-0s7ok4uw	5731	22	A2	A2	NNP
cord-001835-0s7ok4uw	5731	23	)	)	-RRB-
cord-001835-0s7ok4uw	5731	24	,	,	,
cord-001835-0s7ok4uw	5731	25	and	and	CC
cord-001835-0s7ok4uw	5731	26	two	two	CD
cord-001835-0s7ok4uw	5731	27	identical	identical	JJ
cord-001835-0s7ok4uw	5731	28	single	single	RB
cord-001835-0s7ok4uw	5731	29	-	-	HYPH
cord-001835-0s7ok4uw	5731	30	stranded	strand	VBN
cord-001835-0s7ok4uw	5731	31	inhibitory/	inhibitory/	CD
cord-001835-0s7ok4uw	5731	32	carrier	carrier	NN
cord-001835-0s7ok4uw	5731	33	B	b	NN
cord-001835-0s7ok4uw	5731	34	subunits	subunit	NNS
cord-001835-0s7ok4uw	5731	35	(	(	-LRB-
cord-001835-0s7ok4uw	5731	36	FXIII	FXIII	NNP
cord-001835-0s7ok4uw	5731	37	-	-	HYPH
cord-001835-0s7ok4uw	5731	38	B2	B2	NNP
cord-001835-0s7ok4uw	5731	39	)	)	-RRB-
cord-001835-0s7ok4uw	5731	40	.	.	.
cord-001835-0s7ok4uw	5732	1	The	the	DT
cord-001835-0s7ok4uw	5732	2	subunits	subunit	NNS
cord-001835-0s7ok4uw	5732	3	are	be	VBP
cord-001835-0s7ok4uw	5732	4	held	hold	VBN
cord-001835-0s7ok4uw	5732	5	together	together	RB
cord-001835-0s7ok4uw	5732	6	by	by	IN
cord-001835-0s7ok4uw	5732	7	weak	weak	JJ
cord-001835-0s7ok4uw	5732	8	non	non	JJ
cord-001835-0s7ok4uw	5732	9	-	-	JJ
cord-001835-0s7ok4uw	5732	10	covalent	covalent	JJ
cord-001835-0s7ok4uw	5732	11	bonds	bond	NNS
cord-001835-0s7ok4uw	5732	12	.	.	.
cord-001835-0s7ok4uw	5733	1	Contrary	contrary	JJ
cord-001835-0s7ok4uw	5733	2	to	to	IN
cord-001835-0s7ok4uw	5733	3	plasma	plasma	NN
cord-001835-0s7ok4uw	5733	4	FXIII	FXIII	NNP
cord-001835-0s7ok4uw	5733	5	,	,	,
cord-001835-0s7ok4uw	5733	6	cFXIII	cFXIII	NNP
cord-001835-0s7ok4uw	5733	7	is	be	VBZ
cord-001835-0s7ok4uw	5733	8	a	a	DT
cord-001835-0s7ok4uw	5733	9	dimer	dimer	NN
cord-001835-0s7ok4uw	5733	10	(	(	-LRB-
cord-001835-0s7ok4uw	5733	11	FXIII	FXIII	NNP
cord-001835-0s7ok4uw	5733	12	-	-	HYPH
cord-001835-0s7ok4uw	5733	13	A2	A2	NNP
cord-001835-0s7ok4uw	5733	14	)	)	-RRB-
cord-001835-0s7ok4uw	5733	15	devoid	devoid	NN
cord-001835-0s7ok4uw	5733	16	of	of	IN
cord-001835-0s7ok4uw	5733	17	B	b	NN
cord-001835-0s7ok4uw	5733	18	subunits	subunit	NNS
cord-001835-0s7ok4uw	5733	19	.	.	.
cord-001835-0s7ok4uw	5734	1	As	as	RB
cord-001835-0s7ok4uw	5734	2	well	well	RB
cord-001835-0s7ok4uw	5734	3	as	as	IN
cord-001835-0s7ok4uw	5734	4	many	many	JJ
cord-001835-0s7ok4uw	5734	5	other	other	JJ
cord-001835-0s7ok4uw	5734	6	proteins	protein	NNS
cord-001835-0s7ok4uw	5734	7	circulating	circulate	VBG
cord-001835-0s7ok4uw	5734	8	in	in	IN
cord-001835-0s7ok4uw	5734	9	the	the	DT
cord-001835-0s7ok4uw	5734	10	bloodstream	bloodstream	NN
cord-001835-0s7ok4uw	5734	11	,	,	,
cord-001835-0s7ok4uw	5734	12	pFXIII	pFXIII	NNP
cord-001835-0s7ok4uw	5734	13	is	be	VBZ
cord-001835-0s7ok4uw	5734	14	known	know	VBN
cord-001835-0s7ok4uw	5734	15	to	to	TO
cord-001835-0s7ok4uw	5734	16	be	be	VB
cord-001835-0s7ok4uw	5734	17	a	a	DT
cord-001835-0s7ok4uw	5734	18	target	target	NN
cord-001835-0s7ok4uw	5734	19	for	for	IN
cord-001835-0s7ok4uw	5734	20	reactive	reactive	JJ
cord-001835-0s7ok4uw	5734	21	oxygen	oxygen	NN
cord-001835-0s7ok4uw	5734	22	species	specie	NNS
cord-001835-0s7ok4uw	5735	1	(	(	-LRB-
cord-001835-0s7ok4uw	5735	2	ROS	ROS	NNP
cord-001835-0s7ok4uw	5735	3	)	)	-RRB-
cord-001835-0s7ok4uw	5735	4	causing	cause	VBG
cord-001835-0s7ok4uw	5735	5	processes	process	NNS
cord-001835-0s7ok4uw	5735	6	of	of	IN
cord-001835-0s7ok4uw	5735	7	protein	protein	NN
cord-001835-0s7ok4uw	5735	8	oxidative	oxidative	JJ
cord-001835-0s7ok4uw	5735	9	modification	modification	NN
cord-001835-0s7ok4uw	5735	10	.	.	.
cord-001835-0s7ok4uw	5736	1	Since	since	IN
cord-001835-0s7ok4uw	5736	2	the	the	DT
cord-001835-0s7ok4uw	5736	3	conversion	conversion	NN
cord-001835-0s7ok4uw	5736	4	of	of	IN
cord-001835-0s7ok4uw	5736	5	pFXIII	pfxiii	NN
cord-001835-0s7ok4uw	5736	6	to	to	IN
cord-001835-0s7ok4uw	5736	7	the	the	DT
cord-001835-0s7ok4uw	5736	8	active	active	JJ
cord-001835-0s7ok4uw	5736	9	form	form	NN
cord-001835-0s7ok4uw	5736	10	of	of	IN
cord-001835-0s7ok4uw	5736	11	the	the	DT
cord-001835-0s7ok4uw	5736	12	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5736	13	(	(	-LRB-
cord-001835-0s7ok4uw	5736	14	FXIIIa	FXIIIa	NNS
cord-001835-0s7ok4uw	5736	15	)	)	-RRB-
cord-001835-0s7ok4uw	5736	16	is	be	VBZ
cord-001835-0s7ok4uw	5736	17	a	a	DT
cord-001835-0s7ok4uw	5736	18	multistage	multistage	NN
cord-001835-0s7ok4uw	5736	19	process	process	NN
cord-001835-0s7ok4uw	5736	20	,	,	,
cord-001835-0s7ok4uw	5736	21	ozone	ozone	NN
cord-001835-0s7ok4uw	5736	22	-	-	HYPH
cord-001835-0s7ok4uw	5736	23	induced	induce	VBN
cord-001835-0s7ok4uw	5736	24	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5736	25	of	of	IN
cord-001835-0s7ok4uw	5736	26	pFXIII	pFXIII	NNP
cord-001835-0s7ok4uw	5736	27	has	have	VBZ
cord-001835-0s7ok4uw	5736	28	been	be	VBN
cord-001835-0s7ok4uw	5736	29	investigated	investigate	VBN
cord-001835-0s7ok4uw	5736	30	at	at	IN
cord-001835-0s7ok4uw	5736	31	different	different	JJ
cord-001835-0s7ok4uw	5736	32	stages	stage	NNS
cord-001835-0s7ok4uw	5736	33	of	of	IN
cord-001835-0s7ok4uw	5736	34	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5736	35	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5736	36	activation	activation	NN
cord-001835-0s7ok4uw	5736	37	.	.	.
cord-001835-0s7ok4uw	5737	1	The	the	DT
cord-001835-0s7ok4uw	5737	2	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5737	3	results	result	NNS
cord-001835-0s7ok4uw	5737	4	point	point	VBP
cord-001835-0s7ok4uw	5737	5	to	to	IN
cord-001835-0s7ok4uw	5737	6	an	an	DT
cord-001835-0s7ok4uw	5737	7	inhibition	inhibition	NN
cord-001835-0s7ok4uw	5737	8	of	of	IN
cord-001835-0s7ok4uw	5737	9	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5737	10	FXIIIa	FXIIIa	NNS
cord-001835-0s7ok4uw	5737	11	activity	activity	NN
cord-001835-0s7ok4uw	5737	12	depending	depend	VBG
cord-001835-0s7ok4uw	5737	13	largely	largely	RB
cord-001835-0s7ok4uw	5737	14	on	on	IN
cord-001835-0s7ok4uw	5737	15	the	the	DT
cord-001835-0s7ok4uw	5737	16	stage	stage	NN
cord-001835-0s7ok4uw	5737	17	of	of	IN
cord-001835-0s7ok4uw	5737	18	the	the	DT
cord-001835-0s7ok4uw	5737	19	pFXIII	pfxiii	CD
cord-001835-0s7ok4uw	5737	20	conversion	conversion	NN
cord-001835-0s7ok4uw	5737	21	into	into	IN
cord-001835-0s7ok4uw	5737	22	FXIIIa	FXIIIa	NNS
cord-001835-0s7ok4uw	5737	23	at	at	IN
cord-001835-0s7ok4uw	5737	24	which	which	WDT
cord-001835-0s7ok4uw	5737	25	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5737	26	was	be	VBD
cord-001835-0s7ok4uw	5737	27	carried	carry	VBN
cord-001835-0s7ok4uw	5737	28	out	out	RP
cord-001835-0s7ok4uw	5737	29	.	.	.
cord-001835-0s7ok4uw	5738	1	UV-	UV-	NNP
cord-001835-0s7ok4uw	5738	2	,	,	,
cord-001835-0s7ok4uw	5738	3	FTIR	FTIR	NNP
cord-001835-0s7ok4uw	5738	4	-	-	:
cord-001835-0s7ok4uw	5738	5	and	and	CC
cord-001835-0s7ok4uw	5739	1	Raman	Raman	NNP
cord-001835-0s7ok4uw	5739	2	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	5739	3	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	5739	4	that	that	IN
cord-001835-0s7ok4uw	5739	5	chemical	chemical	JJ
cord-001835-0s7ok4uw	5739	6	transformation	transformation	NN
cord-001835-0s7ok4uw	5739	7	of	of	IN
cord-001835-0s7ok4uw	5739	8	cyclic	cyclic	NN
cord-001835-0s7ok4uw	5739	9	,	,	,
cord-001835-0s7ok4uw	5739	10	NH	NH	NNP
cord-001835-0s7ok4uw	5739	11	,	,	,
cord-001835-0s7ok4uw	5739	12	SH	SH	NNP
cord-001835-0s7ok4uw	5739	13	and	and	CC
cord-001835-0s7ok4uw	5739	14	S	S	NNP
cord-001835-0s7ok4uw	5739	15	-	-	HYPH
cord-001835-0s7ok4uw	5739	16	S	S	NNP
cord-001835-0s7ok4uw	5739	17	groups	group	NNS
cord-001835-0s7ok4uw	5739	18	mainly	mainly	RB
cord-001835-0s7ok4uw	5739	19	determines	determine	VBZ
cord-001835-0s7ok4uw	5739	20	the	the	DT
cord-001835-0s7ok4uw	5739	21	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5739	22	of	of	IN
cord-001835-0s7ok4uw	5739	23	amino	amino	JJ
cord-001835-0s7ok4uw	5739	24	acid	acid	NN
cord-001835-0s7ok4uw	5739	25	residues	residue	NNS
cord-001835-0s7ok4uw	5739	26	of	of	IN
cord-001835-0s7ok4uw	5739	27	pFXIII	pFXIII	NNP
cord-001835-0s7ok4uw	5739	28	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	5739	29	chains	chain	NNS
cord-001835-0s7ok4uw	5739	30	.	.	.
cord-001835-0s7ok4uw	5740	1	Conversion	conversion	NN
cord-001835-0s7ok4uw	5740	2	of	of	IN
cord-001835-0s7ok4uw	5740	3	pFXIII	pfxiii	NN
cord-001835-0s7ok4uw	5740	4	to	to	IN
cord-001835-0s7ok4uw	5740	5	FXIIIa	FXIIIa	NNS
cord-001835-0s7ok4uw	5740	6	proved	prove	VBD
cord-001835-0s7ok4uw	5740	7	to	to	TO
cord-001835-0s7ok4uw	5740	8	increase	increase	VB
cord-001835-0s7ok4uw	5740	9	protein	protein	NN
cord-001835-0s7ok4uw	5740	10	susceptibility	susceptibility	NN
cord-001835-0s7ok4uw	5740	11	to	to	IN
cord-001835-0s7ok4uw	5740	12	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5740	13	in	in	IN
cord-001835-0s7ok4uw	5740	14	the	the	DT
cord-001835-0s7ok4uw	5740	15	order	order	NN
cord-001835-0s7ok4uw	5740	16	:	:	:
cord-001835-0s7ok4uw	5741	1	pFXIII	pFXIII	NNP
cord-001835-0s7ok4uw	5741	2	<	<	XX
cord-001835-0s7ok4uw	5741	3	pF	pF	NNP
cord-001835-0s7ok4uw	5741	4	-	-	HYPH
cord-001835-0s7ok4uw	5741	5	XIII	XIII	NNP
cord-001835-0s7ok4uw	5741	6	activated	activate	VBN
cord-001835-0s7ok4uw	5741	7	by	by	IN
cord-001835-0s7ok4uw	5741	8	thrombin	thrombin	NN
cord-001835-0s7ok4uw	5741	9	<	<	XX
cord-001835-0s7ok4uw	5741	10	pFXIII	pFXIII	NNP
cord-001835-0s7ok4uw	5741	11	in	in	IN
cord-001835-0s7ok4uw	5741	12	the	the	DT
cord-001835-0s7ok4uw	5741	13	presence	presence	NN
cord-001835-0s7ok4uw	5741	14	of	of	IN
cord-001835-0s7ok4uw	5741	15	calcium	calcium	NN
cord-001835-0s7ok4uw	5741	16	ions	ion	NNS
cord-001835-0s7ok4uw	5741	17	<	<	XX
cord-001835-0s7ok4uw	5741	18	FXIIIa	FXIIIa	NNS
cord-001835-0s7ok4uw	5741	19	.	.	.
cord-001835-0s7ok4uw	5742	1	With	with	IN
cord-001835-0s7ok4uw	5742	2	the	the	DT
cord-001835-0s7ok4uw	5742	3	aid	aid	NN
cord-001835-0s7ok4uw	5742	4	of	of	IN
cord-001835-0s7ok4uw	5742	5	massspectrometry	massspectrometry	NNP
cord-001835-0s7ok4uw	5742	6	it	-PRON-	PRP
cord-001835-0s7ok4uw	5742	7	has	have	VBZ
cord-001835-0s7ok4uw	5742	8	been	be	VBN
cord-001835-0s7ok4uw	5742	9	demonstrated	demonstrate	VBN
cord-001835-0s7ok4uw	5742	10	that	that	IN
cord-001835-0s7ok4uw	5742	11	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5742	12	leads	lead	VBZ
cord-001835-0s7ok4uw	5742	13	to	to	IN
cord-001835-0s7ok4uw	5742	14	decreasing	decrease	VBG
cord-001835-0s7ok4uw	5742	15	FXIII	FXIII	NNP
cord-001835-0s7ok4uw	5742	16	-	-	HYPH
cord-001835-0s7ok4uw	5742	17	A	A	NNP
cord-001835-0s7ok4uw	5742	18	and	and	CC
cord-001835-0s7ok4uw	5742	19	FXIII	FXIII	NNP
cord-001835-0s7ok4uw	5742	20	-	-	HYPH
cord-001835-0s7ok4uw	5742	21	B	b	NN
cord-001835-0s7ok4uw	5742	22	coverage	coverage	NN
cord-001835-0s7ok4uw	5742	23	both	both	DT
cord-001835-0s7ok4uw	5742	24	in	in	IN
cord-001835-0s7ok4uw	5742	25	the	the	DT
cord-001835-0s7ok4uw	5742	26	forms	form	NNS
cord-001835-0s7ok4uw	5742	27	of	of	IN
cord-001835-0s7ok4uw	5742	28	zymogen	zymogen	NNP
cord-001835-0s7ok4uw	5742	29	and	and	CC
cord-001835-0s7ok4uw	5742	30	in	in	IN
cord-001835-0s7ok4uw	5742	31	the	the	DT
cord-001835-0s7ok4uw	5742	32	presence	presence	NN
cord-001835-0s7ok4uw	5742	33	of	of	IN
cord-001835-0s7ok4uw	5742	34	calcium	calcium	NN
cord-001835-0s7ok4uw	5742	35	ions	ion	NNS
cord-001835-0s7ok4uw	5742	36	.	.	.
cord-001835-0s7ok4uw	5743	1	A	a	DT
cord-001835-0s7ok4uw	5743	2	group	group	NN
cord-001835-0s7ok4uw	5743	3	of	of	IN
cord-001835-0s7ok4uw	5743	4	amino	amino	NN
cord-001835-0s7ok4uw	5743	5	acid	acid	NN
cord-001835-0s7ok4uw	5743	6	residues	residue	NNS
cord-001835-0s7ok4uw	5743	7	involved	involve	VBN
cord-001835-0s7ok4uw	5743	8	in	in	IN
cord-001835-0s7ok4uw	5743	9	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5743	10	modification	modification	NN
cord-001835-0s7ok4uw	5743	11	of	of	IN
cord-001835-0s7ok4uw	5743	12	pFXIII	pFXIII	NNP
cord-001835-0s7ok4uw	5743	13	is	be	VBZ
cord-001835-0s7ok4uw	5743	14	identified	identify	VBN
cord-001835-0s7ok4uw	5743	15	in	in	IN
cord-001835-0s7ok4uw	5743	16	this	this	DT
cord-001835-0s7ok4uw	5743	17	study	study	NN
cord-001835-0s7ok4uw	5743	18	.	.	.
cord-001835-0s7ok4uw	5744	1	The	the	DT
cord-001835-0s7ok4uw	5744	2	oxidation	oxidation	NN
cord-001835-0s7ok4uw	5744	3	of	of	IN
cord-001835-0s7ok4uw	5744	4	either	either	CC
cord-001835-0s7ok4uw	5744	5	cFXIII	cFXIII	NNP
cord-001835-0s7ok4uw	5744	6	or	or	CC
cord-001835-0s7ok4uw	5744	7	cFXIIIa	cFXIIIa	NNP
cord-001835-0s7ok4uw	5744	8	has	have	VBZ
cord-001835-0s7ok4uw	5744	9	revealed	reveal	VBN
cord-001835-0s7ok4uw	5744	10	an	an	DT
cord-001835-0s7ok4uw	5744	11	almost	almost	RB
cord-001835-0s7ok4uw	5744	12	complete	complete	JJ
cord-001835-0s7ok4uw	5744	13	loss	loss	NN
cord-001835-0s7ok4uw	5744	14	of	of	IN
cord-001835-0s7ok4uw	5744	15	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5744	16	activity	activity	NN
cord-001835-0s7ok4uw	5744	17	caused	cause	VBN
cord-001835-0s7ok4uw	5744	18	by	by	IN
cord-001835-0s7ok4uw	5744	19	dramatic	dramatic	JJ
cord-001835-0s7ok4uw	5744	20	changes	change	NNS
cord-001835-0s7ok4uw	5744	21	in	in	IN
cord-001835-0s7ok4uw	5744	22	the	the	DT
cord-001835-0s7ok4uw	5744	23	primary	primary	JJ
cord-001835-0s7ok4uw	5744	24	and	and	CC
cord-001835-0s7ok4uw	5744	25	secondary	secondary	JJ
cord-001835-0s7ok4uw	5744	26	structure	structure	NN
cord-001835-0s7ok4uw	5744	27	of	of	IN
cord-001835-0s7ok4uw	5744	28	the	the	DT
cord-001835-0s7ok4uw	5744	29	proteins	protein	NNS
cord-001835-0s7ok4uw	5744	30	detected	detect	VBN
cord-001835-0s7ok4uw	5744	31	by	by	IN
cord-001835-0s7ok4uw	5744	32	the	the	DT
cord-001835-0s7ok4uw	5744	33	FTIR	FTIR	NNP
cord-001835-0s7ok4uw	5744	34	data	datum	NNS
cord-001835-0s7ok4uw	5744	35	.	.	.
cord-001835-0s7ok4uw	5745	1	Taking	take	VBG
cord-001835-0s7ok4uw	5745	2	into	into	IN
cord-001835-0s7ok4uw	5745	3	account	account	NN
cord-001835-0s7ok4uw	5745	4	these	these	DT
cord-001835-0s7ok4uw	5745	5	new	new	JJ
cord-001835-0s7ok4uw	5745	6	findings	finding	NNS
cord-001835-0s7ok4uw	5745	7	,	,	,
cord-001835-0s7ok4uw	5745	8	it	-PRON-	PRP
cord-001835-0s7ok4uw	5745	9	seems	seem	VBZ
cord-001835-0s7ok4uw	5745	10	reasonable	reasonable	JJ
cord-001835-0s7ok4uw	5745	11	to	to	TO
cord-001835-0s7ok4uw	5745	12	assume	assume	VB
cord-001835-0s7ok4uw	5745	13	that	that	IN
cord-001835-0s7ok4uw	5745	14	the	the	DT
cord-001835-0s7ok4uw	5745	15	inhibitory	inhibitory	JJ
cord-001835-0s7ok4uw	5745	16	/	/	SYM
cord-001835-0s7ok4uw	5745	17	carrier	carrier	NN
cord-001835-0s7ok4uw	5745	18	FXIII	FXIII	NNP
cord-001835-0s7ok4uw	5745	19	-	-	HYPH
cord-001835-0s7ok4uw	5745	20	B	b	NN
cord-001835-0s7ok4uw	5745	21	subunits	subunit	NNS
cord-001835-0s7ok4uw	5745	22	can	can	MD
cord-001835-0s7ok4uw	5745	23	serve	serve	VB
cord-001835-0s7ok4uw	5745	24	as	as	IN
cord-001835-0s7ok4uw	5745	25	scavengers	scavenger	NNS
cord-001835-0s7ok4uw	5745	26	of	of	IN
cord-001835-0s7ok4uw	5745	27	ROS	ROS	NNP
cord-001835-0s7ok4uw	5745	28	.	.	.
cord-001835-0s7ok4uw	5746	1	Hypothetically	hypothetically	RB
cord-001835-0s7ok4uw	5746	2	,	,	,
cord-001835-0s7ok4uw	5746	3	this	this	DT
cord-001835-0s7ok4uw	5746	4	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5746	5	could	could	MD
cord-001835-0s7ok4uw	5746	6	help	help	VB
cord-001835-0s7ok4uw	5746	7	to	to	TO
cord-001835-0s7ok4uw	5746	8	protect	protect	VB
cord-001835-0s7ok4uw	5746	9	the	the	DT
cord-001835-0s7ok4uw	5746	10	key	key	JJ
cord-001835-0s7ok4uw	5746	11	amino	amino	NN
cord-001835-0s7ok4uw	5746	12	acid	acid	NN
cord-001835-0s7ok4uw	5746	13	residues	residue	NNS
cord-001835-0s7ok4uw	5746	14	of	of	IN
cord-001835-0s7ok4uw	5746	15	the	the	DT
cord-001835-0s7ok4uw	5746	16	FXIII	FXIII	NNP
cord-001835-0s7ok4uw	5746	17	-	-	HYPH
cord-001835-0s7ok4uw	5746	18	A	A	NNP
cord-001835-0s7ok4uw	5746	19	subunits	subunit	NNS
cord-001835-0s7ok4uw	5746	20	responsible	responsible	JJ
cord-001835-0s7ok4uw	5746	21	for	for	IN
cord-001835-0s7ok4uw	5746	22	the	the	DT
cord-001835-0s7ok4uw	5746	23	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5746	24	function	function	NN
cord-001835-0s7ok4uw	5746	25	of	of	IN
cord-001835-0s7ok4uw	5746	26	FXIIIa	FXIIIa	NNS
cord-001835-0s7ok4uw	5746	27	.	.	.
cord-001835-0s7ok4uw	5747	1	The	the	DT
cord-001835-0s7ok4uw	5747	2	study	study	NN
cord-001835-0s7ok4uw	5747	3	was	be	VBD
cord-001835-0s7ok4uw	5747	4	supported	support	VBN
cord-001835-0s7ok4uw	5747	5	by	by	IN
cord-001835-0s7ok4uw	5747	6	RFBR	RFBR	NNP
cord-001835-0s7ok4uw	5747	7	,	,	,
cord-001835-0s7ok4uw	5747	8	research	research	NN
cord-001835-0s7ok4uw	5747	9	project	project	NN
cord-001835-0s7ok4uw	5747	10	No	no	NN
cord-001835-0s7ok4uw	5747	11	.	.	NN
cord-001835-0s7ok4uw	5747	12	15	15	CD
cord-001835-0s7ok4uw	5747	13	-	-	SYM
cord-001835-0s7ok4uw	5747	14	15	15	CD
cord-001835-0s7ok4uw	5747	15	-	-	HYPH
cord-001835-0s7ok4uw	5747	16	04	04	CD
cord-001835-0s7ok4uw	5747	17	-	-	HYPH
cord-001835-0s7ok4uw	5747	18	08188a	08188a	CD
cord-001835-0s7ok4uw	5747	19	.	.	.
cord-001835-0s7ok4uw	5748	1	Mass	mass	JJ
cord-001835-0s7ok4uw	5748	2	spectrometry	spectrometry	NN
cord-001835-0s7ok4uw	5748	3	study	study	NN
cord-001835-0s7ok4uw	5748	4	was	be	VBD
cord-001835-0s7ok4uw	5748	5	supported	support	VBN
cord-001835-0s7ok4uw	5748	6	by	by	IN
cord-001835-0s7ok4uw	5748	7	the	the	DT
cord-001835-0s7ok4uw	5748	8	Russian	Russian	NNP
cord-001835-0s7ok4uw	5748	9	Scientific	Scientific	NNP
cord-001835-0s7ok4uw	5748	10	Foundation	Foundation	NNP
cord-001835-0s7ok4uw	5748	11	grant	grant	NN
cord-001835-0s7ok4uw	5748	12	No	no	NN
cord-001835-0s7ok4uw	5748	13	.	.	NN
cord-001835-0s7ok4uw	5748	14	14	14	CD
cord-001835-0s7ok4uw	5748	15	-	-	HYPH
cord-001835-0s7ok4uw	5748	16	24	24	CD
cord-001835-0s7ok4uw	5748	17	-	-	HYPH
cord-001835-0s7ok4uw	5748	18	00114	00114	CD
cord-001835-0s7ok4uw	5748	19	.	.	.
cord-001835-0s7ok4uw	5749	1	Performance	performance	NN
cord-001835-0s7ok4uw	5749	2	and	and	CC
cord-001835-0s7ok4uw	5749	3	quality	quality	NN
cord-001835-0s7ok4uw	5749	4	.	.	.
cord-001835-0s7ok4uw	5750	1	making	make	VBG
cord-001835-0s7ok4uw	5750	2	microcalorimetry	microcalorimetry	JJ
cord-001835-0s7ok4uw	5750	3	simple	simple	JJ
cord-001835-0s7ok4uw	5750	4	with	with	IN
cord-001835-0s7ok4uw	5750	5	microcal	microcal	NNP
cord-001835-0s7ok4uw	5750	6	peaq	peaq	NNP
cord-001835-0s7ok4uw	5750	7	-	-	HYPH
cord-001835-0s7ok4uw	5750	8	itc	itc	NNP
cord-001835-0s7ok4uw	5750	9	Natalia	Natalia	NNP
cord-001835-0s7ok4uw	5750	10	Markova	Markova	NNP
cord-001835-0s7ok4uw	5750	11	1	1	CD
cord-001835-0s7ok4uw	5750	12	,	,	,
cord-001835-0s7ok4uw	5750	13	Ronan	Ronan	NNP
cord-001835-0s7ok4uw	5750	14	O'Brien	O'Brien	NNP
cord-001835-0s7ok4uw	5750	15	1	1	CD
cord-001835-0s7ok4uw	5750	16	,	,	,
cord-001835-0s7ok4uw	5750	17	Mark	Mark	NNP
cord-001835-0s7ok4uw	5750	18	Arsenault	Arsenault	NNP
cord-001835-0s7ok4uw	5750	19	1	1	CD
cord-001835-0s7ok4uw	5750	20	1	1	CD
cord-001835-0s7ok4uw	5750	21	MicroCal	MicroCal	NNP
cord-001835-0s7ok4uw	5750	22	,	,	,
cord-001835-0s7ok4uw	5751	1	Malvern	Malvern	NNP
cord-001835-0s7ok4uw	5751	2	Instruments	Instruments	NNPS
cord-001835-0s7ok4uw	5751	3	Ltd.	Ltd.	NNP
cord-001835-0s7ok4uw	5751	4	Dynamic	dynamic	JJ
cord-001835-0s7ok4uw	5751	5	interactions	interaction	NNS
cord-001835-0s7ok4uw	5751	6	involving	involve	VBG
cord-001835-0s7ok4uw	5751	7	biomolecules	biomolecule	NNS
cord-001835-0s7ok4uw	5751	8	drive	drive	VBP
cord-001835-0s7ok4uw	5751	9	and	and	CC
cord-001835-0s7ok4uw	5751	10	regulate	regulate	VB
cord-001835-0s7ok4uw	5751	11	all	all	DT
cord-001835-0s7ok4uw	5751	12	biological	biological	JJ
cord-001835-0s7ok4uw	5751	13	processes	process	NNS
cord-001835-0s7ok4uw	5751	14	.	.	.
cord-001835-0s7ok4uw	5752	1	Studies	study	NNS
cord-001835-0s7ok4uw	5752	2	of	of	IN
cord-001835-0s7ok4uw	5752	3	biomolecular	biomolecular	JJ
cord-001835-0s7ok4uw	5752	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	5752	5	are	be	VBP
cord-001835-0s7ok4uw	5752	6	fundamentally	fundamentally	RB
cord-001835-0s7ok4uw	5752	7	important	important	JJ
cord-001835-0s7ok4uw	5752	8	in	in	IN
cord-001835-0s7ok4uw	5752	9	all	all	DT
cord-001835-0s7ok4uw	5752	10	areas	area	NNS
cord-001835-0s7ok4uw	5752	11	of	of	IN
cord-001835-0s7ok4uw	5752	12	life	life	NN
cord-001835-0s7ok4uw	5752	13	sciences	science	NNS
cord-001835-0s7ok4uw	5752	14	.	.	.
cord-001835-0s7ok4uw	5753	1	Data	datum	NNS
cord-001835-0s7ok4uw	5753	2	provided	provide	VBN
cord-001835-0s7ok4uw	5753	3	by	by	IN
cord-001835-0s7ok4uw	5753	4	Isothermal	Isothermal	NNP
cord-001835-0s7ok4uw	5753	5	Titration	Titration	NNP
cord-001835-0s7ok4uw	5753	6	Calorimetry	Calorimetry	NNP
cord-001835-0s7ok4uw	5753	7	(	(	-LRB-
cord-001835-0s7ok4uw	5753	8	ITC	ITC	NNP
cord-001835-0s7ok4uw	5753	9	)	)	-RRB-
cord-001835-0s7ok4uw	5753	10	enables	enable	VBZ
cord-001835-0s7ok4uw	5753	11	scientists	scientist	NNS
cord-001835-0s7ok4uw	5753	12	in	in	IN
cord-001835-0s7ok4uw	5753	13	academia	academia	NN
cord-001835-0s7ok4uw	5753	14	and	and	CC
cord-001835-0s7ok4uw	5753	15	industry	industry	NN
cord-001835-0s7ok4uw	5753	16	to	to	TO
cord-001835-0s7ok4uw	5753	17	directly	directly	RB
cord-001835-0s7ok4uw	5753	18	and	and	CC
cord-001835-0s7ok4uw	5753	19	quantitatively	quantitatively	RB
cord-001835-0s7ok4uw	5753	20	characterize	characterize	VB
cord-001835-0s7ok4uw	5753	21	these	these	DT
cord-001835-0s7ok4uw	5753	22	interactions	interaction	NNS
cord-001835-0s7ok4uw	5753	23	in	in	IN
cord-001835-0s7ok4uw	5753	24	solution	solution	NN
cord-001835-0s7ok4uw	5753	25	.	.	.
cord-001835-0s7ok4uw	5754	1	MicroCal	MicroCal	NNP
cord-001835-0s7ok4uw	5754	2	PEAQ	PEAQ	NNP
cord-001835-0s7ok4uw	5754	3	-	-	HYPH
cord-001835-0s7ok4uw	5754	4	ITC	ITC	NNP
cord-001835-0s7ok4uw	5754	5	,	,	,
cord-001835-0s7ok4uw	5754	6	the	the	DT
cord-001835-0s7ok4uw	5754	7	latest	late	JJS
cord-001835-0s7ok4uw	5754	8	generation	generation	NN
cord-001835-0s7ok4uw	5754	9	of	of	IN
cord-001835-0s7ok4uw	5754	10	MicroCal	MicroCal	NNP
cord-001835-0s7ok4uw	5754	11	ITC	ITC	NNP
cord-001835-0s7ok4uw	5754	12	instrumentation	instrumentation	NN
cord-001835-0s7ok4uw	5754	13	,	,	,
cord-001835-0s7ok4uw	5754	14	offers	offer	VBZ
cord-001835-0s7ok4uw	5754	15	a	a	DT
cord-001835-0s7ok4uw	5754	16	whole	whole	JJ
cord-001835-0s7ok4uw	5754	17	range	range	NN
cord-001835-0s7ok4uw	5754	18	of	of	IN
cord-001835-0s7ok4uw	5754	19	solutions	solution	NNS
cord-001835-0s7ok4uw	5754	20	for	for	IN
cord-001835-0s7ok4uw	5754	21	addressing	address	VBG
cord-001835-0s7ok4uw	5754	22	current	current	JJ
cord-001835-0s7ok4uw	5754	23	bottlenecks	bottleneck	NNS
cord-001835-0s7ok4uw	5754	24	associated	associate	VBN
cord-001835-0s7ok4uw	5754	25	with	with	IN
cord-001835-0s7ok4uw	5754	26	interaction	interaction	NN
cord-001835-0s7ok4uw	5754	27	analysis	analysis	NN
cord-001835-0s7ok4uw	5754	28	.	.	.
cord-001835-0s7ok4uw	5755	1	Among	among	IN
cord-001835-0s7ok4uw	5755	2	the	the	DT
cord-001835-0s7ok4uw	5755	3	most	most	RBS
cord-001835-0s7ok4uw	5755	4	recognized	recognize	VBN
cord-001835-0s7ok4uw	5755	5	challenges	challenge	NNS
cord-001835-0s7ok4uw	5755	6	are	be	VBP
cord-001835-0s7ok4uw	5755	7	the	the	DT
cord-001835-0s7ok4uw	5755	8	needs	need	NNS
cord-001835-0s7ok4uw	5755	9	to	to	TO
cord-001835-0s7ok4uw	5755	10	adequately	adequately	RB
cord-001835-0s7ok4uw	5755	11	address	address	VB
cord-001835-0s7ok4uw	5755	12	a	a	DT
cord-001835-0s7ok4uw	5755	13	broad	broad	JJ
cord-001835-0s7ok4uw	5755	14	range	range	NN
cord-001835-0s7ok4uw	5755	15	of	of	IN
cord-001835-0s7ok4uw	5755	16	binding	bind	VBG
cord-001835-0s7ok4uw	5755	17	affinities	affinity	NNS
cord-001835-0s7ok4uw	5755	18	and	and	CC
cord-001835-0s7ok4uw	5755	19	to	to	TO
cord-001835-0s7ok4uw	5755	20	reliably	reliably	RB
cord-001835-0s7ok4uw	5755	21	interpret	interpret	VB
cord-001835-0s7ok4uw	5755	22	binding	bind	VBG
cord-001835-0s7ok4uw	5755	23	data	datum	NNS
cord-001835-0s7ok4uw	5755	24	complicated	complicate	VBN
cord-001835-0s7ok4uw	5755	25	by	by	IN
cord-001835-0s7ok4uw	5755	26	the	the	DT
cord-001835-0s7ok4uw	5755	27	presence	presence	NN
cord-001835-0s7ok4uw	5755	28	of	of	IN
cord-001835-0s7ok4uw	5755	29	inactive	inactive	JJ
cord-001835-0s7ok4uw	5755	30	protein	protein	NN
cord-001835-0s7ok4uw	5755	31	fraction	fraction	NN
cord-001835-0s7ok4uw	5755	32	or	or	CC
cord-001835-0s7ok4uw	5755	33	inherent	inherent	JJ
cord-001835-0s7ok4uw	5755	34	uncertainty	uncertainty	NN
cord-001835-0s7ok4uw	5755	35	in	in	IN
cord-001835-0s7ok4uw	5755	36	the	the	DT
cord-001835-0s7ok4uw	5755	37	concentration	concentration	NN
cord-001835-0s7ok4uw	5755	38	of	of	IN
cord-001835-0s7ok4uw	5755	39	a	a	DT
cord-001835-0s7ok4uw	5755	40	ligand	ligand	NN
cord-001835-0s7ok4uw	5755	41	.	.	.
cord-001835-0s7ok4uw	5756	1	Consistently	consistently	RB
cord-001835-0s7ok4uw	5756	2	high	high	JJ
cord-001835-0s7ok4uw	5756	3	performance	performance	NN
cord-001835-0s7ok4uw	5756	4	of	of	IN
cord-001835-0s7ok4uw	5756	5	MicroCal	MicroCal	NNP
cord-001835-0s7ok4uw	5757	1	PEAQ	PEAQ	NNP
cord-001835-0s7ok4uw	5757	2	-	-	HYPH
cord-001835-0s7ok4uw	5757	3	ITC	ITC	NNP
cord-001835-0s7ok4uw	5757	4	enables	enable	VBZ
cord-001835-0s7ok4uw	5757	5	increased	increase	VBN
cord-001835-0s7ok4uw	5757	6	confidence	confidence	NN
cord-001835-0s7ok4uw	5757	7	and	and	CC
cord-001835-0s7ok4uw	5757	8	data	data	NN
cord-001835-0s7ok4uw	5757	9	resolution	resolution	NN
cord-001835-0s7ok4uw	5757	10	when	when	WRB
cord-001835-0s7ok4uw	5757	11	measuring	measure	VBG
cord-001835-0s7ok4uw	5757	12	low	low	JJ
cord-001835-0s7ok4uw	5757	13	heats	heat	NNS
cord-001835-0s7ok4uw	5757	14	at	at	IN
cord-001835-0s7ok4uw	5757	15	low	low	JJ
cord-001835-0s7ok4uw	5757	16	or	or	CC
cord-001835-0s7ok4uw	5757	17	uncertain	uncertain	JJ
cord-001835-0s7ok4uw	5757	18	sample	sample	NN
cord-001835-0s7ok4uw	5757	19	concentrations	concentration	NNS
cord-001835-0s7ok4uw	5757	20	and	and	CC
cord-001835-0s7ok4uw	5757	21	complex	complex	JJ
cord-001835-0s7ok4uw	5757	22	binding	binding	NN
cord-001835-0s7ok4uw	5757	23	modes	mode	NNS
cord-001835-0s7ok4uw	5757	24	.	.	.
cord-001835-0s7ok4uw	5758	1	The	the	DT
cord-001835-0s7ok4uw	5758	2	new	new	JJ
cord-001835-0s7ok4uw	5758	3	MicroCal	MicroCal	NNP
cord-001835-0s7ok4uw	5758	4	PEAQ	PEAQ	NNP
cord-001835-0s7ok4uw	5758	5	-	-	HYPH
cord-001835-0s7ok4uw	5758	6	ITC	ITC	NNP
cord-001835-0s7ok4uw	5758	7	analysis	analysis	NN
cord-001835-0s7ok4uw	5758	8	software	software	NN
cord-001835-0s7ok4uw	5758	9	allows	allow	VBZ
cord-001835-0s7ok4uw	5758	10	for	for	IN
cord-001835-0s7ok4uw	5758	11	utomated	utomated	JJ
cord-001835-0s7ok4uw	5758	12	data	data	NN
cord-001835-0s7ok4uw	5758	13	analysis	analysis	NN
cord-001835-0s7ok4uw	5758	14	,	,	,
cord-001835-0s7ok4uw	5758	15	minimizing	minimize	VBG
cord-001835-0s7ok4uw	5758	16	analysis	analysis	NN
cord-001835-0s7ok4uw	5758	17	time	time	NN
cord-001835-0s7ok4uw	5758	18	and	and	CC
cord-001835-0s7ok4uw	5758	19	user	user	NN
cord-001835-0s7ok4uw	5758	20	subjectivity	subjectivity	NN
cord-001835-0s7ok4uw	5758	21	in	in	IN
cord-001835-0s7ok4uw	5758	22	assessing	assess	VBG
cord-001835-0s7ok4uw	5758	23	data	data	NN
cord-001835-0s7ok4uw	5758	24	quality	quality	NN
cord-001835-0s7ok4uw	5758	25	.	.	.
cord-001835-0s7ok4uw	5759	1	Data	data	NN
cord-001835-0s7ok4uw	5759	2	quality	quality	NN
cord-001835-0s7ok4uw	5759	3	is	be	VBZ
cord-001835-0s7ok4uw	5759	4	determined	determine	VBN
cord-001835-0s7ok4uw	5759	5	and	and	CC
cord-001835-0s7ok4uw	5759	6	advanced	advanced	JJ
cord-001835-0s7ok4uw	5759	7	fitting	fitting	NN
cord-001835-0s7ok4uw	5759	8	performed	perform	VBN
cord-001835-0s7ok4uw	5759	9	in	in	IN
cord-001835-0s7ok4uw	5759	10	a	a	DT
cord-001835-0s7ok4uw	5759	11	few	few	JJ
cord-001835-0s7ok4uw	5759	12	seconds	second	NNS
cord-001835-0s7ok4uw	5759	13	per	per	IN
cord-001835-0s7ok4uw	5759	14	experiment	experiment	NN
cord-001835-0s7ok4uw	5759	15	allowing	allow	VBG
cord-001835-0s7ok4uw	5759	16	for	for	IN
cord-001835-0s7ok4uw	5759	17	analysis	analysis	NN
cord-001835-0s7ok4uw	5759	18	of	of	IN
cord-001835-0s7ok4uw	5759	19	large	large	JJ
cord-001835-0s7ok4uw	5759	20	data	data	NN
cord-001835-0s7ok4uw	5759	21	sets	set	NNS
cord-001835-0s7ok4uw	5759	22	of	of	IN
cord-001835-0s7ok4uw	5759	23	50	50	CD
cord-001835-0s7ok4uw	5759	24	or	or	CC
cord-001835-0s7ok4uw	5759	25	more	more	JJR
cord-001835-0s7ok4uw	5759	26	experiments	experiment	NNS
cord-001835-0s7ok4uw	5759	27	in	in	IN
cord-001835-0s7ok4uw	5759	28	a	a	DT
cord-001835-0s7ok4uw	5759	29	matter	matter	NN
cord-001835-0s7ok4uw	5759	30	of	of	IN
cord-001835-0s7ok4uw	5759	31	seconds	second	NNS
cord-001835-0s7ok4uw	5759	32	.	.	.
cord-001835-0s7ok4uw	5760	1	Glutamine	glutamine	NN
cord-001835-0s7ok4uw	5760	2	-	-	HYPH
cord-001835-0s7ok4uw	5760	3	rich	rich	JJ
cord-001835-0s7ok4uw	5760	4	activation	activation	NN
cord-001835-0s7ok4uw	5760	5	domain	domain	NN
cord-001835-0s7ok4uw	5760	6	of	of	IN
cord-001835-0s7ok4uw	5760	7	transcription	transcription	NN
cord-001835-0s7ok4uw	5760	8	factor	factor	NN
cord-001835-0s7ok4uw	5760	9	Sp1	sp1	CD
cord-001835-0s7ok4uw	5760	10	-biochemical	-biochemical	JJ
cord-001835-0s7ok4uw	5760	11	activity	activity	NN
cord-001835-0s7ok4uw	5760	12	and	and	CC
cord-001835-0s7ok4uw	5760	13	structure	structure	NN
cord-001835-0s7ok4uw	5761	1	Jun	Jun	NNP
cord-001835-0s7ok4uw	5761	2	Kuwahara	Kuwahara	NNP
cord-001835-0s7ok4uw	5761	3	1	1	CD
cord-001835-0s7ok4uw	5761	4	,	,	,
cord-001835-0s7ok4uw	5761	5	Chisana	Chisana	NNP
cord-001835-0s7ok4uw	5761	6	Uwatoko	Uwatoko	NNP
cord-001835-0s7ok4uw	5761	7	1	1	CD
cord-001835-0s7ok4uw	5762	1	,	,	,
cord-001835-0s7ok4uw	5762	2	Emi	Emi	NNP
cord-001835-0s7ok4uw	5762	3	Hibino	Hibino	NNP
cord-001835-0s7ok4uw	5762	4	2	2	CD
cord-001835-0s7ok4uw	5762	5	,	,	,
cord-001835-0s7ok4uw	5762	6	Katsumi	Katsumi	NNP
cord-001835-0s7ok4uw	5762	7	Matsuzaki	Matsuzaki	NNP
cord-001835-0s7ok4uw	5762	8	2	2	CD
cord-001835-0s7ok4uw	5762	9	,	,	,
cord-001835-0s7ok4uw	5762	10	Masaru	Masaru	NNP
cord-001835-0s7ok4uw	5762	11	Hoshino	Hoshino	NNP
cord-001835-0s7ok4uw	5762	12	2	2	CD
cord-001835-0s7ok4uw	5762	13	1	1	CD
cord-001835-0s7ok4uw	5762	14	Faculty	Faculty	NNP
cord-001835-0s7ok4uw	5762	15	of	of	IN
cord-001835-0s7ok4uw	5762	16	Pharmaceutical	Pharmaceutical	NNP
cord-001835-0s7ok4uw	5762	17	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	5762	18	,	,	,
cord-001835-0s7ok4uw	5762	19	Doshisha	Doshisha	NNP
cord-001835-0s7ok4uw	5762	20	Women	Women	NNPS
cord-001835-0s7ok4uw	5762	21	's	's	POS
cord-001835-0s7ok4uw	5762	22	University	University	NNP
cord-001835-0s7ok4uw	5762	23	,	,	,
cord-001835-0s7ok4uw	5762	24	2	2	CD
cord-001835-0s7ok4uw	5762	25	Graduate	Graduate	NNP
cord-001835-0s7ok4uw	5762	26	School	School	NNP
cord-001835-0s7ok4uw	5762	27	of	of	IN
cord-001835-0s7ok4uw	5762	28	Pharmaceutical	Pharmaceutical	NNP
cord-001835-0s7ok4uw	5762	29	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	5762	30	,	,	,
cord-001835-0s7ok4uw	5762	31	Kyoto	Kyoto	NNP
cord-001835-0s7ok4uw	5762	32	University	University	NNP
cord-001835-0s7ok4uw	5762	33	Transcription	Transcription	NNP
cord-001835-0s7ok4uw	5762	34	factor	factor	NN
cord-001835-0s7ok4uw	5763	1	Sp1	Sp1	NNP
cord-001835-0s7ok4uw	5763	2	is	be	VBZ
cord-001835-0s7ok4uw	5763	3	ubiquitously	ubiquitously	RB
cord-001835-0s7ok4uw	5763	4	expressed	express	VBN
cord-001835-0s7ok4uw	5763	5	in	in	IN
cord-001835-0s7ok4uw	5763	6	a	a	DT
cord-001835-0s7ok4uw	5763	7	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	5763	8	cell	cell	NN
cord-001835-0s7ok4uw	5763	9	,	,	,
cord-001835-0s7ok4uw	5763	10	activates	activate	VBZ
cord-001835-0s7ok4uw	5763	11	reasonably	reasonably	RB
cord-001835-0s7ok4uw	5763	12	large	large	JJ
cord-001835-0s7ok4uw	5763	13	subset	subset	NN
cord-001835-0s7ok4uw	5763	14	of	of	IN
cord-001835-0s7ok4uw	5763	15	mammalian	mammalian	JJ
cord-001835-0s7ok4uw	5763	16	genes	gene	NNS
cord-001835-0s7ok4uw	5763	17	,	,	,
cord-001835-0s7ok4uw	5763	18	and	and	CC
cord-001835-0s7ok4uw	5763	19	is	be	VBZ
cord-001835-0s7ok4uw	5763	20	involved	involve	VBN
cord-001835-0s7ok4uw	5763	21	in	in	IN
cord-001835-0s7ok4uw	5763	22	the	the	DT
cord-001835-0s7ok4uw	5763	23	early	early	JJ
cord-001835-0s7ok4uw	5763	24	development	development	NN
cord-001835-0s7ok4uw	5763	25	of	of	IN
cord-001835-0s7ok4uw	5763	26	an	an	DT
cord-001835-0s7ok4uw	5763	27	organism	organism	NN
cord-001835-0s7ok4uw	5763	28	.	.	.
cord-001835-0s7ok4uw	5764	1	The	the	DT
cord-001835-0s7ok4uw	5764	2	protein	protein	NN
cord-001835-0s7ok4uw	5764	3	comprises	comprise	VBZ
cord-001835-0s7ok4uw	5764	4	two	two	CD
cord-001835-0s7ok4uw	5764	5	glutamine	glutamine	NN
cord-001835-0s7ok4uw	5764	6	-	-	HYPH
cord-001835-0s7ok4uw	5764	7	rich	rich	JJ
cord-001835-0s7ok4uw	5764	8	(	(	-LRB-
cord-001835-0s7ok4uw	5764	9	Q	q	NN
cord-001835-0s7ok4uw	5764	10	-	-	HYPH
cord-001835-0s7ok4uw	5764	11	rich	rich	JJ
cord-001835-0s7ok4uw	5764	12	)	)	-RRB-
cord-001835-0s7ok4uw	5764	13	regions	region	NNS
cord-001835-0s7ok4uw	5764	14	(	(	-LRB-
cord-001835-0s7ok4uw	5764	15	A	a	NN
cord-001835-0s7ok4uw	5764	16	and	and	CC
cord-001835-0s7ok4uw	5764	17	B	b	NN
cord-001835-0s7ok4uw	5764	18	domains	domain	NNS
cord-001835-0s7ok4uw	5764	19	)	)	-RRB-
cord-001835-0s7ok4uw	5764	20	located	locate	VBN
cord-001835-0s7ok4uw	5764	21	in	in	IN
cord-001835-0s7ok4uw	5764	22	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5764	23	N	n	CD
cord-001835-0s7ok4uw	5764	24	-	-	HYPH
cord-001835-0s7ok4uw	5764	25	terminal	terminal	JJ
cord-001835-0s7ok4uw	5764	26	half	half	NN
cord-001835-0s7ok4uw	5764	27	,	,	,
cord-001835-0s7ok4uw	5764	28	while	while	IN
cord-001835-0s7ok4uw	5764	29	three	three	CD
cord-001835-0s7ok4uw	5764	30	tandem	tandem	NN
cord-001835-0s7ok4uw	5764	31	repeats	repeat	NNS
cord-001835-0s7ok4uw	5764	32	of	of	IN
cord-001835-0s7ok4uw	5764	33	C2H2	C2H2	NNP
cord-001835-0s7ok4uw	5764	34	zinc	zinc	VBP
cord-001835-0s7ok4uw	5764	35	finger	finger	NN
cord-001835-0s7ok4uw	5764	36	motif	motif	NN
cord-001835-0s7ok4uw	5764	37	at	at	IN
cord-001835-0s7ok4uw	5764	38	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5764	39	C	c	NN
cord-001835-0s7ok4uw	5764	40	-	-	HYPH
cord-001835-0s7ok4uw	5764	41	terminus	terminus	NN
cord-001835-0s7ok4uw	5764	42	binds	bind	VBZ
cord-001835-0s7ok4uw	5764	43	directly	directly	RB
cord-001835-0s7ok4uw	5764	44	to	to	IN
cord-001835-0s7ok4uw	5764	45	a	a	DT
cord-001835-0s7ok4uw	5764	46	GC	gc	NN
cord-001835-0s7ok4uw	5764	47	-	-	HYPH
cord-001835-0s7ok4uw	5764	48	rich	rich	JJ
cord-001835-0s7ok4uw	5764	49	element	element	NN
cord-001835-0s7ok4uw	5764	50	(	(	-LRB-
cord-001835-0s7ok4uw	5764	51	GC	GC	NNP
cord-001835-0s7ok4uw	5764	52	box	box	NN
cord-001835-0s7ok4uw	5764	53	)	)	-RRB-
cord-001835-0s7ok4uw	5764	54	of	of	IN
cord-001835-0s7ok4uw	5764	55	DNA	DNA	NNP
cord-001835-0s7ok4uw	5764	56	.	.	.
cord-001835-0s7ok4uw	5765	1	In	in	IN
cord-001835-0s7ok4uw	5765	2	general	general	JJ
cord-001835-0s7ok4uw	5765	3	,	,	,
cord-001835-0s7ok4uw	5765	4	Q	q	NN
cord-001835-0s7ok4uw	5765	5	-	-	HYPH
cord-001835-0s7ok4uw	5765	6	rich	rich	JJ
cord-001835-0s7ok4uw	5765	7	domain	domain	NN
cord-001835-0s7ok4uw	5765	8	is	be	VBZ
cord-001835-0s7ok4uw	5765	9	one	one	CD
cord-001835-0s7ok4uw	5765	10	of	of	IN
cord-001835-0s7ok4uw	5765	11	the	the	DT
cord-001835-0s7ok4uw	5765	12	typical	typical	JJ
cord-001835-0s7ok4uw	5765	13	motifs	motif	NNS
cord-001835-0s7ok4uw	5765	14	found	find	VBN
cord-001835-0s7ok4uw	5765	15	in	in	IN
cord-001835-0s7ok4uw	5765	16	trans	trans	JJ
cord-001835-0s7ok4uw	5765	17	-	-	JJ
cord-001835-0s7ok4uw	5765	18	activation	activation	JJ
cord-001835-0s7ok4uw	5765	19	domain	domain	NN
cord-001835-0s7ok4uw	5765	20	of	of	IN
cord-001835-0s7ok4uw	5765	21	transcription	transcription	NN
cord-001835-0s7ok4uw	5765	22	factors	factor	NNS
cord-001835-0s7ok4uw	5765	23	together	together	RB
cord-001835-0s7ok4uw	5765	24	with	with	IN
cord-001835-0s7ok4uw	5765	25	acidic	acidic	JJ
cord-001835-0s7ok4uw	5765	26	and	and	CC
cord-001835-0s7ok4uw	5765	27	proline	proline	JJ
cord-001835-0s7ok4uw	5765	28	-	-	HYPH
cord-001835-0s7ok4uw	5765	29	rich	rich	JJ
cord-001835-0s7ok4uw	5765	30	domains	domain	NNS
cord-001835-0s7ok4uw	5765	31	.	.	.
cord-001835-0s7ok4uw	5766	1	Transcriptional	transcriptional	JJ
cord-001835-0s7ok4uw	5766	2	signal	signal	NN
cord-001835-0s7ok4uw	5766	3	of	of	IN
cord-001835-0s7ok4uw	5766	4	Sp1	Sp1	NNS
cord-001835-0s7ok4uw	5766	5	are	be	VBP
cord-001835-0s7ok4uw	5766	6	transmitted	transmit	VBN
cord-001835-0s7ok4uw	5766	7	via	via	IN
cord-001835-0s7ok4uw	5766	8	interaction	interaction	NN
cord-001835-0s7ok4uw	5766	9	between	between	IN
cord-001835-0s7ok4uw	5766	10	Q	q	NN
cord-001835-0s7ok4uw	5766	11	-	-	HYPH
cord-001835-0s7ok4uw	5766	12	rich	rich	JJ
cord-001835-0s7ok4uw	5766	13	domains	domain	NNS
cord-001835-0s7ok4uw	5766	14	of	of	IN
cord-001835-0s7ok4uw	5766	15	Sp1	sp1	CD
cord-001835-0s7ok4uw	5766	16	and	and	CC
cord-001835-0s7ok4uw	5766	17	different	different	JJ
cord-001835-0s7ok4uw	5766	18	classes	class	NNS
cord-001835-0s7ok4uw	5766	19	of	of	IN
cord-001835-0s7ok4uw	5766	20	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	5766	21	proteins	protein	NNS
cord-001835-0s7ok4uw	5766	22	,	,	,
cord-001835-0s7ok4uw	5766	23	such	such	JJ
cord-001835-0s7ok4uw	5766	24	as	as	IN
cord-001835-0s7ok4uw	5766	25	TATA	TATA	NNP
cord-001835-0s7ok4uw	5766	26	-	-	HYPH
cord-001835-0s7ok4uw	5766	27	binding	bind	VBG
cord-001835-0s7ok4uw	5766	28	protein	protein	NN
cord-001835-0s7ok4uw	5766	29	(	(	-LRB-
cord-001835-0s7ok4uw	5766	30	TBP	TBP	NNP
cord-001835-0s7ok4uw	5766	31	)	)	-RRB-
cord-001835-0s7ok4uw	5766	32	associated	associate	VBN
cord-001835-0s7ok4uw	5766	33	factors	factor	NNS
cord-001835-0s7ok4uw	5766	34	(	(	-LRB-
cord-001835-0s7ok4uw	5766	35	TAFs	TAFs	NNP
cord-001835-0s7ok4uw	5766	36	)	)	-RRB-
cord-001835-0s7ok4uw	5766	37	in	in	IN
cord-001835-0s7ok4uw	5766	38	components	component	NNS
cord-001835-0s7ok4uw	5766	39	of	of	IN
cord-001835-0s7ok4uw	5766	40	basic	basic	JJ
cord-001835-0s7ok4uw	5766	41	transcription	transcription	NN
cord-001835-0s7ok4uw	5766	42	factor	factor	NN
cord-001835-0s7ok4uw	5766	43	complexes	complex	NNS
cord-001835-0s7ok4uw	5766	44	(	(	-LRB-
cord-001835-0s7ok4uw	5766	45	TFII	TFII	NNP
cord-001835-0s7ok4uw	5766	46	)	)	-RRB-
cord-001835-0s7ok4uw	5766	47	.	.	.
cord-001835-0s7ok4uw	5767	1	In	in	IN
cord-001835-0s7ok4uw	5767	2	addition	addition	NN
cord-001835-0s7ok4uw	5767	3	,	,	,
cord-001835-0s7ok4uw	5767	4	self	self	NN
cord-001835-0s7ok4uw	5767	5	-	-	HYPH
cord-001835-0s7ok4uw	5767	6	association	association	NNP
cord-001835-0s7ok4uw	5767	7	of	of	IN
cord-001835-0s7ok4uw	5767	8	Sp1	Sp1	NNP
cord-001835-0s7ok4uw	5767	9	via	via	IN
cord-001835-0s7ok4uw	5767	10	Q	q	NN
cord-001835-0s7ok4uw	5767	11	-	-	HYPH
cord-001835-0s7ok4uw	5767	12	rich	rich	JJ
cord-001835-0s7ok4uw	5767	13	domains	domain	NNS
cord-001835-0s7ok4uw	5767	14	is	be	VBZ
cord-001835-0s7ok4uw	5767	15	also	also	RB
cord-001835-0s7ok4uw	5767	16	important	important	JJ
cord-001835-0s7ok4uw	5767	17	for	for	IN
cord-001835-0s7ok4uw	5767	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5767	19	regulation	regulation	NN
cord-001835-0s7ok4uw	5767	20	of	of	IN
cord-001835-0s7ok4uw	5767	21	transcriptional	transcriptional	JJ
cord-001835-0s7ok4uw	5767	22	activity	activity	NN
cord-001835-0s7ok4uw	5767	23	.	.	.
cord-001835-0s7ok4uw	5768	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5768	2	has	have	VBZ
cord-001835-0s7ok4uw	5768	3	been	be	VBN
cord-001835-0s7ok4uw	5768	4	considered	consider	VBN
cord-001835-0s7ok4uw	5768	5	that	that	IN
cord-001835-0s7ok4uw	5768	6	an	an	DT
cord-001835-0s7ok4uw	5768	7	Sp1	sp1	NN
cord-001835-0s7ok4uw	5768	8	!	!	.
cord-001835-0s7ok4uw	5768	9	molecule	molecule	NN
cord-001835-0s7ok4uw	5768	10	bound	bind	VBN
cord-001835-0s7ok4uw	5768	11	to	to	IN
cord-001835-0s7ok4uw	5768	12	a	a	DT
cord-001835-0s7ok4uw	5768	13	'	'	``
cord-001835-0s7ok4uw	5768	14	distal	distal	JJ
cord-001835-0s7ok4uw	5768	15	'	'	''
cord-001835-0s7ok4uw	5768	16	GC	GC	NNP
cord-001835-0s7ok4uw	5768	17	-	-	HYPH
cord-001835-0s7ok4uw	5768	18	box	box	NN
cord-001835-0s7ok4uw	5768	19	synergistically	synergistically	RB
cord-001835-0s7ok4uw	5768	20	interacts	interact	VBZ
cord-001835-0s7ok4uw	5768	21	with	with	IN
cord-001835-0s7ok4uw	5768	22	another	another	DT
cord-001835-0s7ok4uw	5768	23	Sp1	sp1	NN
cord-001835-0s7ok4uw	5768	24	molecule	molecule	NN
cord-001835-0s7ok4uw	5768	25	at	at	IN
cord-001835-0s7ok4uw	5768	26	a	a	DT
cord-001835-0s7ok4uw	5768	27	'	'	``
cord-001835-0s7ok4uw	5768	28	proximal	proximal	JJ
cord-001835-0s7ok4uw	5768	29	'	'	''
cord-001835-0s7ok4uw	5768	30	binding	binding	NN
cord-001835-0s7ok4uw	5768	31	site	site	NN
cord-001835-0s7ok4uw	5768	32	.	.	.
cord-001835-0s7ok4uw	5769	1	Although	although	IN
cord-001835-0s7ok4uw	5769	2	formation	formation	NN
cord-001835-0s7ok4uw	5769	3	of	of	IN
cord-001835-0s7ok4uw	5769	4	multimers	multimer	NNS
cord-001835-0s7ok4uw	5769	5	via	via	IN
cord-001835-0s7ok4uw	5769	6	Q	q	NN
cord-001835-0s7ok4uw	5769	7	-	-	HYPH
cord-001835-0s7ok4uw	5769	8	rich	rich	JJ
cord-001835-0s7ok4uw	5769	9	domains	domain	NNS
cord-001835-0s7ok4uw	5769	10	seems	seem	VBZ
cord-001835-0s7ok4uw	5769	11	functionally	functionally	RB
cord-001835-0s7ok4uw	5769	12	important	important	JJ
cord-001835-0s7ok4uw	5769	13	for	for	IN
cord-001835-0s7ok4uw	5769	14	Sp1	sp1	CD
cord-001835-0s7ok4uw	5769	15	,	,	,
cord-001835-0s7ok4uw	5769	16	little	little	JJ
cord-001835-0s7ok4uw	5769	17	is	be	VBZ
cord-001835-0s7ok4uw	5769	18	known	know	VBN
cord-001835-0s7ok4uw	5769	19	about	about	IN
cord-001835-0s7ok4uw	5769	20	relevance	relevance	NN
cord-001835-0s7ok4uw	5769	21	between	between	IN
cord-001835-0s7ok4uw	5769	22	biological	biological	JJ
cord-001835-0s7ok4uw	5769	23	activity	activity	NN
cord-001835-0s7ok4uw	5769	24	and	and	CC
cord-001835-0s7ok4uw	5769	25	structural	structural	JJ
cord-001835-0s7ok4uw	5769	26	nature	nature	NN
cord-001835-0s7ok4uw	5769	27	of	of	IN
cord-001835-0s7ok4uw	5769	28	Q	q	NN
cord-001835-0s7ok4uw	5769	29	-	-	HYPH
cord-001835-0s7ok4uw	5769	30	rich	rich	JJ
cord-001835-0s7ok4uw	5769	31	domains	domain	NNS
cord-001835-0s7ok4uw	5769	32	.	.	.
cord-001835-0s7ok4uw	5770	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5770	2	analyzed	analyze	VBD
cord-001835-0s7ok4uw	5770	3	nature	nature	NN
cord-001835-0s7ok4uw	5770	4	of	of	IN
cord-001835-0s7ok4uw	5770	5	glutaminerich	glutaminerich	NNP
cord-001835-0s7ok4uw	5770	6	domains	domain	NNS
cord-001835-0s7ok4uw	5770	7	of	of	IN
cord-001835-0s7ok4uw	5770	8	Sp1	sp1	CD
cord-001835-0s7ok4uw	5770	9	by	by	IN
cord-001835-0s7ok4uw	5770	10	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5770	11	and	and	CC
cord-001835-0s7ok4uw	5770	12	physicochemical	physicochemical	JJ
cord-001835-0s7ok4uw	5770	13	methods	method	NNS
cord-001835-0s7ok4uw	5770	14	.	.	.
cord-001835-0s7ok4uw	5771	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5771	2	found	find	VBD
cord-001835-0s7ok4uw	5771	3	that	that	IN
cord-001835-0s7ok4uw	5771	4	Q	q	NN
cord-001835-0s7ok4uw	5771	5	-	-	HYPH
cord-001835-0s7ok4uw	5771	6	rich	rich	JJ
cord-001835-0s7ok4uw	5771	7	domains	domain	NNS
cord-001835-0s7ok4uw	5771	8	do	do	VBP
cord-001835-0s7ok4uw	5771	9	not	not	RB
cord-001835-0s7ok4uw	5771	10	have	have	VB
cord-001835-0s7ok4uw	5771	11	clear	clear	JJ
cord-001835-0s7ok4uw	5771	12	secondary	secondary	JJ
cord-001835-0s7ok4uw	5771	13	structure	structure	NN
cord-001835-0s7ok4uw	5771	14	whereas	whereas	IN
cord-001835-0s7ok4uw	5771	15	they	-PRON-	PRP
cord-001835-0s7ok4uw	5771	16	can	can	MD
cord-001835-0s7ok4uw	5771	17	indicate	indicate	VB
cord-001835-0s7ok4uw	5771	18	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5771	19	activity	activity	NN
cord-001835-0s7ok4uw	5771	20	.	.	.
cord-001835-0s7ok4uw	5772	1	Detailed	detailed	JJ
cord-001835-0s7ok4uw	5772	2	analysis	analysis	NN
cord-001835-0s7ok4uw	5772	3	of	of	IN
cord-001835-0s7ok4uw	5772	4	NMR	NMR	NNP
cord-001835-0s7ok4uw	5772	5	spectra	spectrum	NNS
cord-001835-0s7ok4uw	5772	6	indicated	indicate	VBD
cord-001835-0s7ok4uw	5772	7	interaction	interaction	NN
cord-001835-0s7ok4uw	5772	8	between	between	IN
cord-001835-0s7ok4uw	5772	9	the	the	DT
cord-001835-0s7ok4uw	5772	10	domains	domain	NNS
cord-001835-0s7ok4uw	5772	11	.	.	.
cord-001835-0s7ok4uw	5773	1	The	the	DT
cord-001835-0s7ok4uw	5773	2	Q	q	NN
cord-001835-0s7ok4uw	5773	3	-	-	HYPH
cord-001835-0s7ok4uw	5773	4	rich	rich	JJ
cord-001835-0s7ok4uw	5773	5	domains	domain	NNS
cord-001835-0s7ok4uw	5773	6	of	of	IN
cord-001835-0s7ok4uw	5773	7	Sp1	Sp1	NNP
cord-001835-0s7ok4uw	5773	8	might	may	MD
cord-001835-0s7ok4uw	5773	9	be	be	VB
cord-001835-0s7ok4uw	5773	10	one	one	CD
cord-001835-0s7ok4uw	5773	11	of	of	IN
cord-001835-0s7ok4uw	5773	12	the	the	DT
cord-001835-0s7ok4uw	5773	13	intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	5773	14	disordered	disordered	JJ
cord-001835-0s7ok4uw	5773	15	proteins	protein	NNS
cord-001835-0s7ok4uw	5773	16	(	(	-LRB-
cord-001835-0s7ok4uw	5773	17	IDP	IDP	NNP
cord-001835-0s7ok4uw	5773	18	)	)	-RRB-
cord-001835-0s7ok4uw	5773	19	.	.	.
cord-001835-0s7ok4uw	5774	1	CHIPping	chip	VBG
cord-001835-0s7ok4uw	5774	2	away	away	RB
cord-001835-0s7ok4uw	5774	3	at	at	IN
cord-001835-0s7ok4uw	5774	4	the	the	DT
cord-001835-0s7ok4uw	5774	5	yeast	yeast	NN
cord-001835-0s7ok4uw	5774	6	proteome	proteome	NN
cord-001835-0s7ok4uw	5774	7	:	:	:
cord-001835-0s7ok4uw	5774	8	redesigning	redesign	VBG
cord-001835-0s7ok4uw	5774	9	an	an	DT
cord-001835-0s7ok4uw	5774	10	E3	e3	NN
cord-001835-0s7ok4uw	5774	11	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	5774	12	ligase	ligase	NN
cord-001835-0s7ok4uw	5774	13	for	for	IN
cord-001835-0s7ok4uw	5774	14	targeted	target	VBN
cord-001835-0s7ok4uw	5774	15	protein	protein	NN
cord-001835-0s7ok4uw	5774	16	degradation	degradation	NN
cord-001835-0s7ok4uw	5774	17	Michael	Michael	NNP
cord-001835-0s7ok4uw	5774	18	Hinrichsen	Hinrichsen	NNP
cord-001835-0s7ok4uw	5774	19	1	1	CD
cord-001835-0s7ok4uw	5774	20	,	,	,
cord-001835-0s7ok4uw	5774	21	Lynne	Lynne	NNP
cord-001835-0s7ok4uw	5774	22	Regan	Regan	NNP
cord-001835-0s7ok4uw	5775	1	1	1	CD
cord-001835-0s7ok4uw	5775	2	1	1	CD
cord-001835-0s7ok4uw	5775	3	One	one	CD
cord-001835-0s7ok4uw	5775	4	of	of	IN
cord-001835-0s7ok4uw	5775	5	the	the	DT
cord-001835-0s7ok4uw	5775	6	central	central	JJ
cord-001835-0s7ok4uw	5775	7	goals	goal	NNS
cord-001835-0s7ok4uw	5775	8	of	of	IN
cord-001835-0s7ok4uw	5775	9	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	5775	10	biology	biology	NN
cord-001835-0s7ok4uw	5775	11	is	be	VBZ
cord-001835-0s7ok4uw	5775	12	to	to	TO
cord-001835-0s7ok4uw	5775	13	exploit	exploit	VB
cord-001835-0s7ok4uw	5775	14	biological	biological	JJ
cord-001835-0s7ok4uw	5775	15	systems	system	NNS
cord-001835-0s7ok4uw	5775	16	in	in	IN
cord-001835-0s7ok4uw	5775	17	order	order	NN
cord-001835-0s7ok4uw	5775	18	to	to	TO
cord-001835-0s7ok4uw	5775	19	produce	produce	VB
cord-001835-0s7ok4uw	5775	20	compounds	compound	NNS
cord-001835-0s7ok4uw	5775	21	of	of	IN
cord-001835-0s7ok4uw	5775	22	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	5775	23	or	or	CC
cord-001835-0s7ok4uw	5775	24	industrial	industrial	JJ
cord-001835-0s7ok4uw	5775	25	value	value	NN
cord-001835-0s7ok4uw	5775	26	1	1	CD
cord-001835-0s7ok4uw	5775	27	.	.	.
cord-001835-0s7ok4uw	5776	1	Often	often	RB
cord-001835-0s7ok4uw	5776	2	,	,	,
cord-001835-0s7ok4uw	5776	3	these	these	DT
cord-001835-0s7ok4uw	5776	4	efforts	effort	NNS
cord-001835-0s7ok4uw	5776	5	are	be	VBP
cord-001835-0s7ok4uw	5776	6	complicated	complicate	VBN
cord-001835-0s7ok4uw	5776	7	by	by	IN
cord-001835-0s7ok4uw	5776	8	the	the	DT
cord-001835-0s7ok4uw	5776	9	many	many	JJ
cord-001835-0s7ok4uw	5776	10	natural	natural	JJ
cord-001835-0s7ok4uw	5776	11	biochemical	biochemical	JJ
cord-001835-0s7ok4uw	5776	12	pathways	pathway	NNS
cord-001835-0s7ok4uw	5776	13	in	in	IN
cord-001835-0s7ok4uw	5776	14	cells	cell	NNS
cord-001835-0s7ok4uw	5776	15	that	that	WDT
cord-001835-0s7ok4uw	5776	16	can	can	MD
cord-001835-0s7ok4uw	5776	17	compete	compete	VB
cord-001835-0s7ok4uw	5776	18	for	for	IN
cord-001835-0s7ok4uw	5776	19	the	the	DT
cord-001835-0s7ok4uw	5776	20	same	same	JJ
cord-001835-0s7ok4uw	5776	21	small	small	JJ
cord-001835-0s7ok4uw	5776	22	molecule	molecule	NN
cord-001835-0s7ok4uw	5776	23	precursors	precursor	NNS
cord-001835-0s7ok4uw	5776	24	.	.	.
cord-001835-0s7ok4uw	5777	1	Currently	currently	RB
cord-001835-0s7ok4uw	5777	2	,	,	,
cord-001835-0s7ok4uw	5777	3	the	the	DT
cord-001835-0s7ok4uw	5777	4	most	most	RBS
cord-001835-0s7ok4uw	5777	5	common	common	JJ
cord-001835-0s7ok4uw	5777	6	solution	solution	NN
cord-001835-0s7ok4uw	5777	7	is	be	VBZ
cord-001835-0s7ok4uw	5777	8	to	to	TO
cord-001835-0s7ok4uw	5777	9	simply	simply	RB
cord-001835-0s7ok4uw	5777	10	delete	delete	VB
cord-001835-0s7ok4uw	5777	11	the	the	DT
cord-001835-0s7ok4uw	5777	12	genes	gene	NNS
cord-001835-0s7ok4uw	5777	13	coding	code	VBG
cord-001835-0s7ok4uw	5777	14	for	for	IN
cord-001835-0s7ok4uw	5777	15	the	the	DT
cord-001835-0s7ok4uw	5777	16	competing	compete	VBG
cord-001835-0s7ok4uw	5777	17	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5777	18	2	2	CD
cord-001835-0s7ok4uw	5777	19	.	.	.
cord-001835-0s7ok4uw	5778	1	While	while	IN
cord-001835-0s7ok4uw	5778	2	such	such	PDT
cord-001835-0s7ok4uw	5778	3	an	an	DT
cord-001835-0s7ok4uw	5778	4	approach	approach	NN
cord-001835-0s7ok4uw	5778	5	has	have	VBZ
cord-001835-0s7ok4uw	5778	6	been	be	VBN
cord-001835-0s7ok4uw	5778	7	successful	successful	JJ
cord-001835-0s7ok4uw	5778	8	,	,	,
cord-001835-0s7ok4uw	5778	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	5778	10	is	be	VBZ
cord-001835-0s7ok4uw	5778	11	only	only	RB
cord-001835-0s7ok4uw	5778	12	applicable	applicable	JJ
cord-001835-0s7ok4uw	5778	13	to	to	IN
cord-001835-0s7ok4uw	5778	14	nonessential	nonessential	JJ
cord-001835-0s7ok4uw	5778	15	genes	gene	NNS
cord-001835-0s7ok4uw	5778	16	and	and	CC
cord-001835-0s7ok4uw	5778	17	can	can	MD
cord-001835-0s7ok4uw	5778	18	produce	produce	VB
cord-001835-0s7ok4uw	5778	19	unintended	unintended	JJ
cord-001835-0s7ok4uw	5778	20	off	off	IN
cord-001835-0s7ok4uw	5778	21	-	-	HYPH
cord-001835-0s7ok4uw	5778	22	target	target	NN
cord-001835-0s7ok4uw	5778	23	effects	effect	NNS
cord-001835-0s7ok4uw	5778	24	such	such	JJ
cord-001835-0s7ok4uw	5778	25	as	as	IN
cord-001835-0s7ok4uw	5778	26	decreased	decrease	VBN
cord-001835-0s7ok4uw	5778	27	cell	cell	NN
cord-001835-0s7ok4uw	5778	28	viability	viability	NN
cord-001835-0s7ok4uw	5778	29	2	2	CD
cord-001835-0s7ok4uw	5778	30	.	.	.
cord-001835-0s7ok4uw	5779	1	An	an	DT
cord-001835-0s7ok4uw	5779	2	alternative	alternative	JJ
cord-001835-0s7ok4uw	5779	3	strategy	strategy	NN
cord-001835-0s7ok4uw	5779	4	is	be	VBZ
cord-001835-0s7ok4uw	5779	5	to	to	TO
cord-001835-0s7ok4uw	5779	6	instead	instead	RB
cord-001835-0s7ok4uw	5779	7	target	target	VB
cord-001835-0s7ok4uw	5779	8	proteins	protein	NNS
cord-001835-0s7ok4uw	5779	9	directly	directly	RB
cord-001835-0s7ok4uw	5779	10	for	for	IN
cord-001835-0s7ok4uw	5779	11	degradation	degradation	NN
cord-001835-0s7ok4uw	5779	12	.	.	.
cord-001835-0s7ok4uw	5780	1	Using	use	VBG
cord-001835-0s7ok4uw	5780	2	this	this	DT
cord-001835-0s7ok4uw	5780	3	strategy	strategy	NN
cord-001835-0s7ok4uw	5780	4	,	,	,
cord-001835-0s7ok4uw	5780	5	scientists	scientist	NNS
cord-001835-0s7ok4uw	5780	6	would	would	MD
cord-001835-0s7ok4uw	5780	7	first	first	RB
cord-001835-0s7ok4uw	5780	8	grow	grow	VB
cord-001835-0s7ok4uw	5780	9	cultures	culture	NNS
cord-001835-0s7ok4uw	5780	10	of	of	IN
cord-001835-0s7ok4uw	5780	11	engineered	engineer	VBN
cord-001835-0s7ok4uw	5780	12	cells	cell	NNS
cord-001835-0s7ok4uw	5780	13	to	to	IN
cord-001835-0s7ok4uw	5780	14	high	high	JJ
cord-001835-0s7ok4uw	5780	15	densities	density	NNS
cord-001835-0s7ok4uw	5780	16	under	under	IN
cord-001835-0s7ok4uw	5780	17	permissive	permissive	JJ
cord-001835-0s7ok4uw	5780	18	conditions	condition	NNS
cord-001835-0s7ok4uw	5780	19	(	(	-LRB-
cord-001835-0s7ok4uw	5780	20	i.e.	i.e.	FW
cord-001835-0s7ok4uw	5780	21	targeted	target	VBN
cord-001835-0s7ok4uw	5780	22	proteins	protein	NNS
cord-001835-0s7ok4uw	5780	23	are	be	VBP
cord-001835-0s7ok4uw	5780	24	stably	stably	RB
cord-001835-0s7ok4uw	5780	25	expressed	express	VBN
cord-001835-0s7ok4uw	5780	26	)	)	-RRB-
cord-001835-0s7ok4uw	5780	27	.	.	.
cord-001835-0s7ok4uw	5781	1	Then	then	RB
cord-001835-0s7ok4uw	5781	2	,	,	,
cord-001835-0s7ok4uw	5781	3	once	once	IN
cord-001835-0s7ok4uw	5781	4	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	5781	5	cell	cell	NN
cord-001835-0s7ok4uw	5781	6	density	density	NN
cord-001835-0s7ok4uw	5781	7	has	have	VBZ
cord-001835-0s7ok4uw	5781	8	been	be	VBN
cord-001835-0s7ok4uw	5781	9	reached	reach	VBN
cord-001835-0s7ok4uw	5781	10	,	,	,
cord-001835-0s7ok4uw	5781	11	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5781	12	of	of	IN
cord-001835-0s7ok4uw	5781	13	competing	compete	VBG
cord-001835-0s7ok4uw	5781	14	pathways	pathway	NNS
cord-001835-0s7ok4uw	5781	15	would	would	MD
cord-001835-0s7ok4uw	5781	16	be	be	VB
cord-001835-0s7ok4uw	5781	17	rapidly	rapidly	RB
cord-001835-0s7ok4uw	5781	18	degraded	degrade	VBN
cord-001835-0s7ok4uw	5781	19	,	,	,
cord-001835-0s7ok4uw	5781	20	resulting	result	VBG
cord-001835-0s7ok4uw	5781	21	in	in	IN
cord-001835-0s7ok4uw	5781	22	the	the	DT
cord-001835-0s7ok4uw	5781	23	rapid	rapid	JJ
cord-001835-0s7ok4uw	5781	24	production	production	NN
cord-001835-0s7ok4uw	5781	25	of	of	IN
cord-001835-0s7ok4uw	5781	26	high	high	JJ
cord-001835-0s7ok4uw	5781	27	concentrations	concentration	NNS
cord-001835-0s7ok4uw	5781	28	of	of	IN
cord-001835-0s7ok4uw	5781	29	the	the	DT
cord-001835-0s7ok4uw	5781	30	compound	compound	NN
cord-001835-0s7ok4uw	5781	31	of	of	IN
cord-001835-0s7ok4uw	5781	32	interest	interest	NN
cord-001835-0s7ok4uw	5781	33	.	.	.
cord-001835-0s7ok4uw	5782	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5782	2	propose	propose	VBP
cord-001835-0s7ok4uw	5782	3	to	to	TO
cord-001835-0s7ok4uw	5782	4	create	create	VB
cord-001835-0s7ok4uw	5782	5	such	such	PDT
cord-001835-0s7ok4uw	5782	6	a	a	DT
cord-001835-0s7ok4uw	5782	7	tool	tool	NN
cord-001835-0s7ok4uw	5782	8	by	by	IN
cord-001835-0s7ok4uw	5782	9	reengineering	reengineere	VBG
cord-001835-0s7ok4uw	5782	10	the	the	DT
cord-001835-0s7ok4uw	5782	11	C	C	NNP
cord-001835-0s7ok4uw	5782	12	-	-	HYPH
cord-001835-0s7ok4uw	5782	13	terminus	terminus	NN
cord-001835-0s7ok4uw	5782	14	of	of	IN
cord-001835-0s7ok4uw	5782	15	Hsp70	Hsp70	NNP
cord-001835-0s7ok4uw	5782	16	interacting	interact	VBG
cord-001835-0s7ok4uw	5782	17	protein	protein	NN
cord-001835-0s7ok4uw	5782	18	(	(	-LRB-
cord-001835-0s7ok4uw	5782	19	CHIP	CHIP	NNP
cord-001835-0s7ok4uw	5782	20	)	)	-RRB-
cord-001835-0s7ok4uw	5782	21	,	,	,
cord-001835-0s7ok4uw	5782	22	an	an	DT
cord-001835-0s7ok4uw	5782	23	E3	e3	NN
cord-001835-0s7ok4uw	5782	24	ubiquitin	ubiquitin	NN
cord-001835-0s7ok4uw	5782	25	ligase	ligase	NN
cord-001835-0s7ok4uw	5782	26	.	.	.
cord-001835-0s7ok4uw	5783	1	CHIP	chip	NN
cord-001835-0s7ok4uw	5783	2	recognizes	recognize	VBZ
cord-001835-0s7ok4uw	5783	3	substrate	substrate	NN
cord-001835-0s7ok4uw	5783	4	proteins	protein	NNS
cord-001835-0s7ok4uw	5783	5	through	through	IN
cord-001835-0s7ok4uw	5783	6	a	a	DT
cord-001835-0s7ok4uw	5783	7	short	short	JJ
cord-001835-0s7ok4uw	5783	8	C	c	NN
cord-001835-0s7ok4uw	5783	9	-	-	HYPH
cord-001835-0s7ok4uw	5783	10	terminal	terminal	NN
cord-001835-0s7ok4uw	5783	11	peptide	peptide	NN
cord-001835-0s7ok4uw	5783	12	tag	tag	NN
cord-001835-0s7ok4uw	5783	13	on	on	IN
cord-001835-0s7ok4uw	5783	14	target	target	NN
cord-001835-0s7ok4uw	5783	15	proteins3	proteins3	NN
cord-001835-0s7ok4uw	5783	16	.	.	.
cord-001835-0s7ok4uw	5784	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5784	2	have	have	VBP
cord-001835-0s7ok4uw	5784	3	shown	show	VBN
cord-001835-0s7ok4uw	5784	4	that	that	IN
cord-001835-0s7ok4uw	5784	5	fusing	fuse	VBG
cord-001835-0s7ok4uw	5784	6	this	this	DT
cord-001835-0s7ok4uw	5784	7	tag	tag	NN
cord-001835-0s7ok4uw	5784	8	to	to	IN
cord-001835-0s7ok4uw	5784	9	non	non	JJ
cord-001835-0s7ok4uw	5784	10	-	-	JJ
cord-001835-0s7ok4uw	5784	11	native	native	JJ
cord-001835-0s7ok4uw	5784	12	substrates	substrate	NNS
cord-001835-0s7ok4uw	5784	13	is	be	VBZ
cord-001835-0s7ok4uw	5784	14	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	5784	15	for	for	IN
cord-001835-0s7ok4uw	5784	16	ubiquitination	ubiquitination	NN
cord-001835-0s7ok4uw	5784	17	in	in	IN
cord-001835-0s7ok4uw	5784	18	vitro	vitro	FW
cord-001835-0s7ok4uw	5784	19	(	(	-LRB-
cord-001835-0s7ok4uw	5784	20	data	datum	NNS
cord-001835-0s7ok4uw	5784	21	not	not	RB
cord-001835-0s7ok4uw	5784	22	published	publish	VBN
cord-001835-0s7ok4uw	5784	23	)	)	-RRB-
cord-001835-0s7ok4uw	5784	24	.	.	.
cord-001835-0s7ok4uw	5785	1	Cellular	cellular	JJ
cord-001835-0s7ok4uw	5785	2	assays	assay	NNS
cord-001835-0s7ok4uw	5785	3	have	have	VBP
cord-001835-0s7ok4uw	5785	4	also	also	RB
cord-001835-0s7ok4uw	5785	5	been	be	VBN
cord-001835-0s7ok4uw	5785	6	performed	perform	VBN
cord-001835-0s7ok4uw	5785	7	in	in	IN
cord-001835-0s7ok4uw	5785	8	S.	S.	NNP
cord-001835-0s7ok4uw	5785	9	Cerevisiae	Cerevisiae	NNP
cord-001835-0s7ok4uw	5785	10	,	,	,
cord-001835-0s7ok4uw	5785	11	a	a	DT
cord-001835-0s7ok4uw	5785	12	model	model	NN
cord-001835-0s7ok4uw	5785	13	organism	organism	NN
cord-001835-0s7ok4uw	5785	14	commonly	commonly	RB
cord-001835-0s7ok4uw	5785	15	used	use	VBN
cord-001835-0s7ok4uw	5785	16	in	in	IN
cord-001835-0s7ok4uw	5785	17	metabolic	metabolic	JJ
cord-001835-0s7ok4uw	5785	18	engineering	engineering	NN
cord-001835-0s7ok4uw	5785	19	applications1	applications1	NN
cord-001835-0s7ok4uw	5785	20	.	.	.
cord-001835-0s7ok4uw	5786	1	As	as	IN
cord-001835-0s7ok4uw	5786	2	a	a	DT
cord-001835-0s7ok4uw	5786	3	number	number	NN
cord-001835-0s7ok4uw	5786	4	of	of	IN
cord-001835-0s7ok4uw	5786	5	native	native	JJ
cord-001835-0s7ok4uw	5786	6	yeast	yeast	NN
cord-001835-0s7ok4uw	5786	7	proteins	protein	NNS
cord-001835-0s7ok4uw	5786	8	possess	possess	VBP
cord-001835-0s7ok4uw	5786	9	C	c	NN
cord-001835-0s7ok4uw	5786	10	-	-	HYPH
cord-001835-0s7ok4uw	5786	11	termini	termini	NNP
cord-001835-0s7ok4uw	5786	12	similar	similar	JJ
cord-001835-0s7ok4uw	5786	13	to	to	IN
cord-001835-0s7ok4uw	5786	14	that	that	DT
cord-001835-0s7ok4uw	5786	15	of	of	IN
cord-001835-0s7ok4uw	5786	16	CHIP	CHIP	NNP
cord-001835-0s7ok4uw	5786	17	's	's	POS
cord-001835-0s7ok4uw	5786	18	native	native	JJ
cord-001835-0s7ok4uw	5786	19	substrates	substrate	NNS
cord-001835-0s7ok4uw	5786	20	(	(	-LRB-
cord-001835-0s7ok4uw	5786	21	data	datum	NNS
cord-001835-0s7ok4uw	5786	22	not	not	RB
cord-001835-0s7ok4uw	5786	23	published	publish	VBN
cord-001835-0s7ok4uw	5786	24	)	)	-RRB-
cord-001835-0s7ok4uw	5786	25	,	,	,
cord-001835-0s7ok4uw	5786	26	it	-PRON-	PRP
cord-001835-0s7ok4uw	5786	27	was	be	VBD
cord-001835-0s7ok4uw	5786	28	necessary	necessary	JJ
cord-001835-0s7ok4uw	5786	29	to	to	TO
cord-001835-0s7ok4uw	5786	30	develop	develop	VB
cord-001835-0s7ok4uw	5786	31	an	an	DT
cord-001835-0s7ok4uw	5786	32	orthogonal	orthogonal	JJ
cord-001835-0s7ok4uw	5786	33	CHIP	chip	NN
cord-001835-0s7ok4uw	5786	34	-	-	HYPH
cord-001835-0s7ok4uw	5786	35	peptide	peptide	NN
cord-001835-0s7ok4uw	5786	36	pair	pair	NN
cord-001835-0s7ok4uw	5786	37	.	.	.
cord-001835-0s7ok4uw	5787	1	This	this	DT
cord-001835-0s7ok4uw	5787	2	was	be	VBD
cord-001835-0s7ok4uw	5787	3	achieved	achieve	VBN
cord-001835-0s7ok4uw	5787	4	by	by	IN
cord-001835-0s7ok4uw	5787	5	replacing	replace	VBG
cord-001835-0s7ok4uw	5787	6	CHIP	chip	NN
cord-001835-0s7ok4uw	5787	7	's	's	POS
cord-001835-0s7ok4uw	5787	8	natural	natural	JJ
cord-001835-0s7ok4uw	5787	9	TPR	TPR	NNP
cord-001835-0s7ok4uw	5787	10	ligand	ligand	NN
cord-001835-0s7ok4uw	5787	11	-	-	HYPH
cord-001835-0s7ok4uw	5787	12	binding	bind	VBG
cord-001835-0s7ok4uw	5787	13	domain	domain	NN
cord-001835-0s7ok4uw	5787	14	with	with	IN
cord-001835-0s7ok4uw	5787	15	a	a	DT
cord-001835-0s7ok4uw	5787	16	ligand	ligand	NN
cord-001835-0s7ok4uw	5787	17	-	-	HYPH
cord-001835-0s7ok4uw	5787	18	binding	bind	VBG
cord-001835-0s7ok4uw	5787	19	domain	domain	NN
cord-001835-0s7ok4uw	5787	20	engineered	engineer	VBN
cord-001835-0s7ok4uw	5787	21	previously	previously	RB
cord-001835-0s7ok4uw	5787	22	in	in	IN
cord-001835-0s7ok4uw	5787	23	the	the	DT
cord-001835-0s7ok4uw	5787	24	Regan	Regan	NNP
cord-001835-0s7ok4uw	5787	25	Lab	Lab	NNP
cord-001835-0s7ok4uw	5787	26	4	4	CD
cord-001835-0s7ok4uw	5787	27	.	.	.
cord-001835-0s7ok4uw	5788	1	The	the	DT
cord-001835-0s7ok4uw	5788	2	altered	altered	JJ
cord-001835-0s7ok4uw	5788	3	CHIP	chip	NN
cord-001835-0s7ok4uw	5788	4	construct	construct	NN
cord-001835-0s7ok4uw	5788	5	has	have	VBZ
cord-001835-0s7ok4uw	5788	6	been	be	VBN
cord-001835-0s7ok4uw	5788	7	shown	show	VBN
cord-001835-0s7ok4uw	5788	8	to	to	TO
cord-001835-0s7ok4uw	5788	9	be	be	VB
cord-001835-0s7ok4uw	5788	10	active	active	JJ
cord-001835-0s7ok4uw	5788	11	both	both	DT
cord-001835-0s7ok4uw	5788	12	in	in	IN
cord-001835-0s7ok4uw	5788	13	vitro	vitro	FW
cord-001835-0s7ok4uw	5788	14	and	and	CC
cord-001835-0s7ok4uw	5788	15	in	in	IN
cord-001835-0s7ok4uw	5788	16	vivo	vivo	NN
cord-001835-0s7ok4uw	5788	17	,	,	,
cord-001835-0s7ok4uw	5788	18	and	and	CC
cord-001835-0s7ok4uw	5788	19	produces	produce	VBZ
cord-001835-0s7ok4uw	5788	20	an	an	DT
cord-001835-0s7ok4uw	5788	21	altered	alter	VBN
cord-001835-0s7ok4uw	5788	22	growth	growth	NN
cord-001835-0s7ok4uw	5788	23	phenotype	phenotype	NN
cord-001835-0s7ok4uw	5788	24	when	when	WRB
cord-001835-0s7ok4uw	5788	25	targeted	target	VBN
cord-001835-0s7ok4uw	5788	26	against	against	IN
cord-001835-0s7ok4uw	5788	27	an	an	DT
cord-001835-0s7ok4uw	5788	28	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5788	29	involved	involve	VBN
cord-001835-0s7ok4uw	5788	30	in	in	IN
cord-001835-0s7ok4uw	5788	31	uracil	uracil	NN
cord-001835-0s7ok4uw	5788	32	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	5788	33	.	.	.
cord-001835-0s7ok4uw	5789	1	Future	future	JJ
cord-001835-0s7ok4uw	5789	2	work	work	NN
cord-001835-0s7ok4uw	5789	3	will	will	MD
cord-001835-0s7ok4uw	5789	4	focus	focus	VB
cord-001835-0s7ok4uw	5789	5	on	on	IN
cord-001835-0s7ok4uw	5789	6	further	further	JJ
cord-001835-0s7ok4uw	5789	7	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	5789	8	characterization	characterization	NN
cord-001835-0s7ok4uw	5789	9	of	of	IN
cord-001835-0s7ok4uw	5789	10	the	the	DT
cord-001835-0s7ok4uw	5789	11	engineered	engineer	VBN
cord-001835-0s7ok4uw	5789	12	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5789	13	,	,	,
cord-001835-0s7ok4uw	5789	14	increasing	increase	VBG
cord-001835-0s7ok4uw	5789	15	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5789	16	activity	activity	NN
cord-001835-0s7ok4uw	5789	17	,	,	,
cord-001835-0s7ok4uw	5789	18	and	and	CC
cord-001835-0s7ok4uw	5789	19	introducing	introduce	VBG
cord-001835-0s7ok4uw	5789	20	the	the	DT
cord-001835-0s7ok4uw	5789	21	system	system	NN
cord-001835-0s7ok4uw	5789	22	into	into	IN
cord-001835-0s7ok4uw	5789	23	a	a	DT
cord-001835-0s7ok4uw	5789	24	proof	proof	NN
cord-001835-0s7ok4uw	5789	25	of	of	IN
cord-001835-0s7ok4uw	5789	26	concept	concept	NN
cord-001835-0s7ok4uw	5789	27	synthetic	synthetic	JJ
cord-001835-0s7ok4uw	5789	28	biology	biology	NN
cord-001835-0s7ok4uw	5789	29	application	application	NN
cord-001835-0s7ok4uw	5789	30	.	.	.
cord-001835-0s7ok4uw	5790	1	Advances	advance	NNS
cord-001835-0s7ok4uw	5790	2	in	in	IN
cord-001835-0s7ok4uw	5790	3	modern	modern	JJ
cord-001835-0s7ok4uw	5790	4	sequencing	sequencing	NN
cord-001835-0s7ok4uw	5790	5	techniques	technique	NNS
cord-001835-0s7ok4uw	5790	6	have	have	VBP
cord-001835-0s7ok4uw	5790	7	resulted	result	VBN
cord-001835-0s7ok4uw	5790	8	in	in	IN
cord-001835-0s7ok4uw	5790	9	an	an	DT
cord-001835-0s7ok4uw	5790	10	explosion	explosion	NN
cord-001835-0s7ok4uw	5790	11	of	of	IN
cord-001835-0s7ok4uw	5790	12	genomic	genomic	JJ
cord-001835-0s7ok4uw	5790	13	data	datum	NNS
cord-001835-0s7ok4uw	5790	14	.	.	.
cord-001835-0s7ok4uw	5791	1	Correctly	correctly	RB
cord-001835-0s7ok4uw	5791	2	classifying	classify	VBG
cord-001835-0s7ok4uw	5791	3	this	this	DT
cord-001835-0s7ok4uw	5791	4	new	new	JJ
cord-001835-0s7ok4uw	5791	5	wealth	wealth	NN
cord-001835-0s7ok4uw	5791	6	of	of	IN
cord-001835-0s7ok4uw	5791	7	information	information	NN
cord-001835-0s7ok4uw	5791	8	can	can	MD
cord-001835-0s7ok4uw	5791	9	be	be	VB
cord-001835-0s7ok4uw	5791	10	daunting	daunt	VBG
cord-001835-0s7ok4uw	5791	11	not	not	RB
cord-001835-0s7ok4uw	5791	12	only	only	RB
cord-001835-0s7ok4uw	5791	13	because	because	IN
cord-001835-0s7ok4uw	5791	14	of	of	IN
cord-001835-0s7ok4uw	5791	15	the	the	DT
cord-001835-0s7ok4uw	5791	16	sheer	sheer	JJ
cord-001835-0s7ok4uw	5791	17	volume	volume	NN
cord-001835-0s7ok4uw	5791	18	of	of	IN
cord-001835-0s7ok4uw	5791	19	sequence	sequence	NN
cord-001835-0s7ok4uw	5791	20	data	datum	NNS
cord-001835-0s7ok4uw	5791	21	,	,	,
cord-001835-0s7ok4uw	5791	22	but	but	CC
cord-001835-0s7ok4uw	5791	23	also	also	RB
cord-001835-0s7ok4uw	5791	24	because	because	IN
cord-001835-0s7ok4uw	5791	25	the	the	DT
cord-001835-0s7ok4uw	5791	26	propagation	propagation	NN
cord-001835-0s7ok4uw	5791	27	of	of	IN
cord-001835-0s7ok4uw	5791	28	erroneous	erroneous	JJ
cord-001835-0s7ok4uw	5791	29	and	and	CC
cord-001835-0s7ok4uw	5791	30	less	less	JJR
cord-001835-0s7ok4uw	5791	31	-	-	HYPH
cord-001835-0s7ok4uw	5791	32	than	than	IN
cord-001835-0s7ok4uw	5791	33	-	-	HYPH
cord-001835-0s7ok4uw	5791	34	ideal	ideal	NN
cord-001835-0s7ok4uw	5791	35	names	name	NNS
cord-001835-0s7ok4uw	5791	36	and	and	CC
cord-001835-0s7ok4uw	5791	37	functional	functional	JJ
cord-001835-0s7ok4uw	5791	38	characterizations	characterization	NNS
cord-001835-0s7ok4uw	5791	39	in	in	IN
cord-001835-0s7ok4uw	5791	40	the	the	DT
cord-001835-0s7ok4uw	5791	41	current	current	JJ
cord-001835-0s7ok4uw	5791	42	databases	database	NNS
cord-001835-0s7ok4uw	5791	43	gets	get	VBZ
cord-001835-0s7ok4uw	5791	44	in	in	IN
cord-001835-0s7ok4uw	5791	45	the	the	DT
cord-001835-0s7ok4uw	5791	46	way	way	NN
cord-001835-0s7ok4uw	5791	47	of	of	IN
cord-001835-0s7ok4uw	5791	48	functional	functional	JJ
cord-001835-0s7ok4uw	5791	49	classification	classification	NN
cord-001835-0s7ok4uw	5791	50	by	by	IN
cord-001835-0s7ok4uw	5791	51	mere	mere	JJ
cord-001835-0s7ok4uw	5791	52	sequence	sequence	NN
cord-001835-0s7ok4uw	5791	53	similarity	similarity	NN
cord-001835-0s7ok4uw	5791	54	.	.	.
cord-001835-0s7ok4uw	5792	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5792	2	are	be	VBP
cord-001835-0s7ok4uw	5792	3	investigating	investigate	VBG
cord-001835-0s7ok4uw	5792	4	the	the	DT
cord-001835-0s7ok4uw	5792	5	extent	extent	NN
cord-001835-0s7ok4uw	5792	6	to	to	TO
cord-001835-0s7ok4uw	5792	7	which	which	WDT
cord-001835-0s7ok4uw	5792	8	protein	protein	NN
cord-001835-0s7ok4uw	5792	9	domain	domain	NN
cord-001835-0s7ok4uw	5792	10	architecture	architecture	NN
cord-001835-0s7ok4uw	5792	11	can	can	MD
cord-001835-0s7ok4uw	5792	12	be	be	VB
cord-001835-0s7ok4uw	5792	13	utilized	utilize	VBN
cord-001835-0s7ok4uw	5792	14	to	to	TO
cord-001835-0s7ok4uw	5792	15	define	define	VB
cord-001835-0s7ok4uw	5792	16	groups	group	NNS
cord-001835-0s7ok4uw	5792	17	of	of	IN
cord-001835-0s7ok4uw	5792	18	proteins	protein	NNS
cord-001835-0s7ok4uw	5792	19	with	with	IN
cord-001835-0s7ok4uw	5792	20	similarities	similarity	NNS
cord-001835-0s7ok4uw	5792	21	in	in	IN
cord-001835-0s7ok4uw	5792	22	molecular	molecular	JJ
cord-001835-0s7ok4uw	5792	23	function	function	NN
cord-001835-0s7ok4uw	5792	24	,	,	,
cord-001835-0s7ok4uw	5792	25	and	and	CC
cord-001835-0s7ok4uw	5792	26	whether	whether	IN
cord-001835-0s7ok4uw	5792	27	we	-PRON-	PRP
cord-001835-0s7ok4uw	5792	28	can	can	MD
cord-001835-0s7ok4uw	5792	29	derive	derive	VB
cord-001835-0s7ok4uw	5792	30	corresponding	correspond	VBG
cord-001835-0s7ok4uw	5792	31	functional	functional	JJ
cord-001835-0s7ok4uw	5792	32	"	"	``
cord-001835-0s7ok4uw	5792	33	labels	label	NNS
cord-001835-0s7ok4uw	5792	34	"	"	''
cord-001835-0s7ok4uw	5792	35	,	,	,
cord-001835-0s7ok4uw	5792	36	starting	start	VBG
cord-001835-0s7ok4uw	5792	37	with	with	IN
cord-001835-0s7ok4uw	5792	38	some	some	DT
cord-001835-0s7ok4uw	5792	39	of	of	IN
cord-001835-0s7ok4uw	5792	40	the	the	DT
cord-001835-0s7ok4uw	5792	41	most	most	RBS
cord-001835-0s7ok4uw	5792	42	common	common	JJ
cord-001835-0s7ok4uw	5792	43	domain	domain	NN
cord-001835-0s7ok4uw	5792	44	architectures	architecture	NNS
cord-001835-0s7ok4uw	5792	45	found	find	VBN
cord-001835-0s7ok4uw	5792	46	in	in	IN
cord-001835-0s7ok4uw	5792	47	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	5792	48	.	.	.
cord-001835-0s7ok4uw	5793	1	To	to	IN
cord-001835-0s7ok4uw	5793	2	this	this	DT
cord-001835-0s7ok4uw	5793	3	end	end	NN
cord-001835-0s7ok4uw	5793	4	,	,	,
cord-001835-0s7ok4uw	5793	5	we	-PRON-	PRP
cord-001835-0s7ok4uw	5793	6	have	have	VBP
cord-001835-0s7ok4uw	5793	7	developed	develop	VBN
cord-001835-0s7ok4uw	5793	8	an	an	DT
cord-001835-0s7ok4uw	5793	9	in	in	IN
cord-001835-0s7ok4uw	5793	10	-	-	HYPH
cord-001835-0s7ok4uw	5793	11	house	house	NN
cord-001835-0s7ok4uw	5793	12	procedure	procedure	NN
cord-001835-0s7ok4uw	5793	13	called	call	VBN
cord-001835-0s7ok4uw	5793	14	SPARCLE	SPARCLE	NNP
cord-001835-0s7ok4uw	5793	15	(	(	-LRB-
cord-001835-0s7ok4uw	5793	16	'	'	``
cord-001835-0s7ok4uw	5793	17	SPecific	specific	JJ
cord-001835-0s7ok4uw	5793	18	ARChitecture	architecture	NN
cord-001835-0s7ok4uw	5793	19	Labeling	Labeling	NNP
cord-001835-0s7ok4uw	5793	20	Engine	Engine	NNP
cord-001835-0s7ok4uw	5793	21	'	'	''
cord-001835-0s7ok4uw	5793	22	)	)	-RRB-
cord-001835-0s7ok4uw	5793	23	that	that	WDT
cord-001835-0s7ok4uw	5793	24	lets	let	VBZ
cord-001835-0s7ok4uw	5793	25	us	-PRON-	PRP
cord-001835-0s7ok4uw	5793	26	track	track	VB
cord-001835-0s7ok4uw	5793	27	and	and	CC
cord-001835-0s7ok4uw	5793	28	examine	examine	VB
cord-001835-0s7ok4uw	5793	29	specific	specific	JJ
cord-001835-0s7ok4uw	5793	30	or	or	CC
cord-001835-0s7ok4uw	5793	31	sub	sub	JJ
cord-001835-0s7ok4uw	5793	32	-	-	JJ
cord-001835-0s7ok4uw	5793	33	family	family	NN
cord-001835-0s7ok4uw	5793	34	domain	domain	NN
cord-001835-0s7ok4uw	5793	35	architectures	architecture	NNS
cord-001835-0s7ok4uw	5793	36	,	,	,
cord-001835-0s7ok4uw	5793	37	resulting	result	VBG
cord-001835-0s7ok4uw	5793	38	from	from	IN
cord-001835-0s7ok4uw	5793	39	annotating	annotate	VBG
cord-001835-0s7ok4uw	5793	40	protein	protein	NN
cord-001835-0s7ok4uw	5793	41	sequences	sequence	NNS
cord-001835-0s7ok4uw	5793	42	with	with	IN
cord-001835-0s7ok4uw	5793	43	domain	domain	NN
cord-001835-0s7ok4uw	5793	44	footprints	footprint	NNS
cord-001835-0s7ok4uw	5793	45	provided	provide	VBN
cord-001835-0s7ok4uw	5793	46	by	by	IN
cord-001835-0s7ok4uw	5793	47	the	the	DT
cord-001835-0s7ok4uw	5793	48	Conserved	Conserved	NNP
cord-001835-0s7ok4uw	5793	49	Domain	Domain	NNP
cord-001835-0s7ok4uw	5793	50	Database	Database	NNP
cord-001835-0s7ok4uw	5793	51	(	(	-LRB-
cord-001835-0s7ok4uw	5793	52	CDD	CDD	NNP
cord-001835-0s7ok4uw	5793	53	)	)	-RRB-
cord-001835-0s7ok4uw	5793	54	,	,	,
cord-001835-0s7ok4uw	5793	55	which	which	WDT
cord-001835-0s7ok4uw	5793	56	includes	include	VBZ
cord-001835-0s7ok4uw	5793	57	hierarchical	hierarchical	JJ
cord-001835-0s7ok4uw	5793	58	classifications	classification	NNS
cord-001835-0s7ok4uw	5793	59	for	for	IN
cord-001835-0s7ok4uw	5793	60	many	many	JJ
cord-001835-0s7ok4uw	5793	61	common	common	JJ
cord-001835-0s7ok4uw	5793	62	domain	domain	NN
cord-001835-0s7ok4uw	5793	63	families	family	NNS
cord-001835-0s7ok4uw	5793	64	.	.	.
cord-001835-0s7ok4uw	5794	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5794	2	will	will	MD
cord-001835-0s7ok4uw	5794	3	discuss	discuss	VB
cord-001835-0s7ok4uw	5794	4	how	how	WRB
cord-001835-0s7ok4uw	5794	5	the	the	DT
cord-001835-0s7ok4uw	5794	6	proteins	protein	NNS
cord-001835-0s7ok4uw	5794	7	are	be	VBP
cord-001835-0s7ok4uw	5794	8	grouped	group	VBN
cord-001835-0s7ok4uw	5794	9	into	into	IN
cord-001835-0s7ok4uw	5794	10	specific	specific	JJ
cord-001835-0s7ok4uw	5794	11	architectures	architecture	NNS
cord-001835-0s7ok4uw	5794	12	,	,	,
cord-001835-0s7ok4uw	5794	13	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5794	14	successes	success	NNS
cord-001835-0s7ok4uw	5794	15	in	in	IN
cord-001835-0s7ok4uw	5794	16	assigning	assign	VBG
cord-001835-0s7ok4uw	5794	17	functional	functional	JJ
cord-001835-0s7ok4uw	5794	18	labels	label	NNS
cord-001835-0s7ok4uw	5794	19	,	,	,
cord-001835-0s7ok4uw	5794	20	and	and	CC
cord-001835-0s7ok4uw	5794	21	the	the	DT
cord-001835-0s7ok4uw	5794	22	major	major	JJ
cord-001835-0s7ok4uw	5794	23	limitations	limitation	NNS
cord-001835-0s7ok4uw	5794	24	we	-PRON-	PRP
cord-001835-0s7ok4uw	5794	25	have	have	VBP
cord-001835-0s7ok4uw	5794	26	encountered	encounter	VBN
cord-001835-0s7ok4uw	5794	27	to	to	IN
cord-001835-0s7ok4uw	5794	28	date	date	NN
cord-001835-0s7ok4uw	5794	29	.	.	.
cord-001835-0s7ok4uw	5795	1	While	while	IN
cord-001835-0s7ok4uw	5795	2	we	-PRON-	PRP
cord-001835-0s7ok4uw	5795	3	will	will	MD
cord-001835-0s7ok4uw	5795	4	be	be	VB
cord-001835-0s7ok4uw	5795	5	able	able	JJ
cord-001835-0s7ok4uw	5795	6	to	to	TO
cord-001835-0s7ok4uw	5795	7	assign	assign	VB
cord-001835-0s7ok4uw	5795	8	functional	functional	JJ
cord-001835-0s7ok4uw	5795	9	labels	label	NNS
cord-001835-0s7ok4uw	5795	10	to	to	IN
cord-001835-0s7ok4uw	5795	11	a	a	DT
cord-001835-0s7ok4uw	5795	12	large	large	JJ
cord-001835-0s7ok4uw	5795	13	fraction	fraction	NN
cord-001835-0s7ok4uw	5795	14	of	of	IN
cord-001835-0s7ok4uw	5795	15	protein	protein	NN
cord-001835-0s7ok4uw	5795	16	models	model	NNS
cord-001835-0s7ok4uw	5795	17	derived	derive	VBN
cord-001835-0s7ok4uw	5795	18	from	from	IN
cord-001835-0s7ok4uw	5795	19	genome	genome	NN
cord-001835-0s7ok4uw	5795	20	sequences	sequence	NNS
cord-001835-0s7ok4uw	5795	21	,	,	,
cord-001835-0s7ok4uw	5795	22	this	this	DT
cord-001835-0s7ok4uw	5795	23	effort	effort	NN
cord-001835-0s7ok4uw	5795	24	has	have	VBZ
cord-001835-0s7ok4uw	5795	25	the	the	DT
cord-001835-0s7ok4uw	5795	26	added	add	VBN
cord-001835-0s7ok4uw	5795	27	benefit	benefit	NN
cord-001835-0s7ok4uw	5795	28	of	of	IN
cord-001835-0s7ok4uw	5795	29	pointing	point	VBG
cord-001835-0s7ok4uw	5795	30	out	out	RP
cord-001835-0s7ok4uw	5795	31	insufficient	insufficient	JJ
cord-001835-0s7ok4uw	5795	32	coverage	coverage	NN
cord-001835-0s7ok4uw	5795	33	and	and	CC
cord-001835-0s7ok4uw	5795	34	resolution	resolution	NN
cord-001835-0s7ok4uw	5795	35	of	of	IN
cord-001835-0s7ok4uw	5795	36	the	the	DT
cord-001835-0s7ok4uw	5795	37	current	current	JJ
cord-001835-0s7ok4uw	5795	38	protein	protein	NN
cord-001835-0s7ok4uw	5795	39	domain	domain	NN
cord-001835-0s7ok4uw	5795	40	model	model	NN
cord-001835-0s7ok4uw	5795	41	collections	collection	NNS
cord-001835-0s7ok4uw	5795	42	that	that	WDT
cord-001835-0s7ok4uw	5795	43	constitute	constitute	VBP
cord-001835-0s7ok4uw	5795	44	CDD	CDD	NNP
cord-001835-0s7ok4uw	5795	45	.	.	.
cord-001835-0s7ok4uw	5796	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5796	2	will	will	MD
cord-001835-0s7ok4uw	5796	3	also	also	RB
cord-001835-0s7ok4uw	5796	4	discuss	discuss	VB
cord-001835-0s7ok4uw	5796	5	alternative	alternative	JJ
cord-001835-0s7ok4uw	5796	6	procedures	procedure	NNS
cord-001835-0s7ok4uw	5796	7	that	that	WDT
cord-001835-0s7ok4uw	5796	8	utilize	utilize	VBP
cord-001835-0s7ok4uw	5796	9	pre	pre	JJ
cord-001835-0s7ok4uw	5796	10	-	-	JJ
cord-001835-0s7ok4uw	5796	11	computed	computed	JJ
cord-001835-0s7ok4uw	5796	12	domain	domain	NN
cord-001835-0s7ok4uw	5796	13	annotation	annotation	NN
cord-001835-0s7ok4uw	5796	14	for	for	IN
cord-001835-0s7ok4uw	5796	15	clustering	cluster	VBG
cord-001835-0s7ok4uw	5796	16	protein	protein	NN
cord-001835-0s7ok4uw	5796	17	sequences	sequence	NNS
cord-001835-0s7ok4uw	5796	18	at	at	IN
cord-001835-0s7ok4uw	5796	19	a	a	DT
cord-001835-0s7ok4uw	5796	20	level	level	NN
cord-001835-0s7ok4uw	5796	21	that	that	WDT
cord-001835-0s7ok4uw	5796	22	is	be	VBZ
cord-001835-0s7ok4uw	5796	23	well	well	RB
cord-001835-0s7ok4uw	5796	24	suited	suited	JJ
cord-001835-0s7ok4uw	5796	25	for	for	IN
cord-001835-0s7ok4uw	5796	26	functional	functional	JJ
cord-001835-0s7ok4uw	5796	27	labeling	labeling	NN
cord-001835-0s7ok4uw	5796	28	.	.	.
cord-001835-0s7ok4uw	5797	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5797	2	hope	hope	VBP
cord-001835-0s7ok4uw	5797	3	that	that	IN
cord-001835-0s7ok4uw	5797	4	this	this	DT
cord-001835-0s7ok4uw	5797	5	preliminary	preliminary	JJ
cord-001835-0s7ok4uw	5797	6	study	study	NN
cord-001835-0s7ok4uw	5797	7	will	will	MD
cord-001835-0s7ok4uw	5797	8	help	help	VB
cord-001835-0s7ok4uw	5797	9	to	to	TO
cord-001835-0s7ok4uw	5797	10	identify	identify	VB
cord-001835-0s7ok4uw	5797	11	approaches	approach	NNS
cord-001835-0s7ok4uw	5797	12	that	that	WDT
cord-001835-0s7ok4uw	5797	13	facilitate	facilitate	VBP
cord-001835-0s7ok4uw	5797	14	rapid	rapid	JJ
cord-001835-0s7ok4uw	5797	15	and	and	CC
cord-001835-0s7ok4uw	5797	16	accurate	accurate	JJ
cord-001835-0s7ok4uw	5797	17	annotation	annotation	NN
cord-001835-0s7ok4uw	5797	18	of	of	IN
cord-001835-0s7ok4uw	5797	19	genomes	genome	NNS
cord-001835-0s7ok4uw	5797	20	with	with	IN
cord-001835-0s7ok4uw	5797	21	a	a	DT
cord-001835-0s7ok4uw	5797	22	minimum	minimum	NN
cord-001835-0s7ok4uw	5797	23	of	of	IN
cord-001835-0s7ok4uw	5797	24	manual	manual	JJ
cord-001835-0s7ok4uw	5797	25	intervention	intervention	NN
cord-001835-0s7ok4uw	5797	26	.	.	.
cord-001835-0s7ok4uw	5798	1	PEGylated	PEGylated	NNP
cord-001835-0s7ok4uw	5798	2	Amyloid	Amyloid	NNP
cord-001835-0s7ok4uw	5798	3	Peptide	Peptide	NNP
cord-001835-0s7ok4uw	5798	4	Nanocontainer	Nanocontainer	NNP
cord-001835-0s7ok4uw	5798	5	Delivery	Delivery	NNP
cord-001835-0s7ok4uw	5798	6	and	and	CC
cord-001835-0s7ok4uw	5798	7	Release	Release	NNP
cord-001835-0s7ok4uw	5798	8	System	System	NNP
cord-001835-0s7ok4uw	5798	9	Self	Self	NNP
cord-001835-0s7ok4uw	5798	10	-	-	HYPH
cord-001835-0s7ok4uw	5798	11	Assembly	Assembly	NNP
cord-001835-0s7ok4uw	5798	12	of	of	IN
cord-001835-0s7ok4uw	5798	13	Telechelic	Telechelic	NNP
cord-001835-0s7ok4uw	5798	14	PEG	PEG	NNP
cord-001835-0s7ok4uw	5798	15	End	End	NNP
cord-001835-0s7ok4uw	5798	16	-	-	HYPH
cord-001835-0s7ok4uw	5798	17	capped	cap	VBN
cord-001835-0s7ok4uw	5798	18	with	with	IN
cord-001835-0s7ok4uw	5798	19	Hydrophobic	Hydrophobic	NNP
cord-001835-0s7ok4uw	5798	20	Dipeptides	dipeptide	NNS
cord-001835-0s7ok4uw	5799	1	Collagen	Collagen	NNP
cord-001835-0s7ok4uw	5799	2	Stimulating	Stimulating	NNP
cord-001835-0s7ok4uw	5799	3	Effect	Effect	NNP
cord-001835-0s7ok4uw	5799	4	of	of	IN
cord-001835-0s7ok4uw	5799	5	Peptide	Peptide	NNP
cord-001835-0s7ok4uw	5799	6	Amphiphile	Amphiphile	NNP
cord-001835-0s7ok4uw	5799	7	C16-KTTKS	C16-KTTKS	NNP
cord-001835-0s7ok4uw	5799	8	on	on	IN
cord-001835-0s7ok4uw	5799	9	Human	Human	NNP
cord-001835-0s7ok4uw	5799	10	Fibroblasts	Fibroblasts	NNP
cord-001835-0s7ok4uw	5799	11	Self	Self	NNP
cord-001835-0s7ok4uw	5799	12	-	-	HYPH
cord-001835-0s7ok4uw	5799	13	Assembly	Assembly	NNP
cord-001835-0s7ok4uw	5799	14	of	of	IN
cord-001835-0s7ok4uw	5799	15	Palmitoyl	Palmitoyl	NNP
cord-001835-0s7ok4uw	5799	16	Lipopeptides	Lipopeptides	NNP
cord-001835-0s7ok4uw	5799	17	Used	use	VBN
cord-001835-0s7ok4uw	5799	18	in	in	IN
cord-001835-0s7ok4uw	5799	19	Skin	skin	NN
cord-001835-0s7ok4uw	5799	20	Care	Care	NNP
cord-001835-0s7ok4uw	5799	21	Products	Products	NNPS
cord-001835-0s7ok4uw	5799	22	Bioactive	Bioactive	NNP
cord-001835-0s7ok4uw	5799	23	films	film	NNS
cord-001835-0s7ok4uw	5799	24	produced	produce	VBN
cord-001835-0s7ok4uw	5799	25	from	from	IN
cord-001835-0s7ok4uw	5799	26	selfassembling	selfassemble	VBG
cord-001835-0s7ok4uw	5799	27	peptide	peptide	JJ
cord-001835-0s7ok4uw	5799	28	amphiphiles	amphiphile	NNS
cord-001835-0s7ok4uw	5799	29	as	as	IN
cord-001835-0s7ok4uw	5799	30	versatile	versatile	JJ
cord-001835-0s7ok4uw	5799	31	substrates	substrate	NNS
cord-001835-0s7ok4uw	5799	32	for	for	IN
cord-001835-0s7ok4uw	5799	33	tuning	tune	VBG
cord-001835-0s7ok4uw	5799	34	cell	cell	NN
cord-001835-0s7ok4uw	5799	35	adhesion	adhesion	NN
cord-001835-0s7ok4uw	5799	36	and	and	CC
cord-001835-0s7ok4uw	5799	37	tissue	tissue	NN
cord-001835-0s7ok4uw	5799	38	architecture	architecture	NN
cord-001835-0s7ok4uw	5799	39	in	in	IN
cord-001835-0s7ok4uw	5799	40	serum	serum	NN
cord-001835-0s7ok4uw	5799	41	-	-	HYPH
cord-001835-0s7ok4uw	5799	42	free	free	JJ
cord-001835-0s7ok4uw	5799	43	conditions	condition	NNS
cord-001835-0s7ok4uw	5799	44	Influence	influence	NN
cord-001835-0s7ok4uw	5799	45	of	of	IN
cord-001835-0s7ok4uw	5799	46	elastase	elastase	NN
cord-001835-0s7ok4uw	5799	47	on	on	IN
cord-001835-0s7ok4uw	5799	48	alanine	alanine	JJ
cord-001835-0s7ok4uw	5799	49	-	-	HYPH
cord-001835-0s7ok4uw	5799	50	rich	rich	JJ
cord-001835-0s7ok4uw	5799	51	peptide	peptide	NN
cord-001835-0s7ok4uw	5799	52	hydrogels	hydrogel	NNS
cord-001835-0s7ok4uw	5800	1	Interaction	interaction	NN
cord-001835-0s7ok4uw	5800	2	Between	between	IN
cord-001835-0s7ok4uw	5800	3	a	a	DT
cord-001835-0s7ok4uw	5800	4	Cationic	Cationic	NNP
cord-001835-0s7ok4uw	5800	5	Surfactant	Surfactant	NNP
cord-001835-0s7ok4uw	5800	6	-	-	HYPH
cord-001835-0s7ok4uw	5800	7	Like	Like	NNP
cord-001835-0s7ok4uw	5800	8	Peptide	Peptide	NNP
cord-001835-0s7ok4uw	5800	9	and	and	CC
cord-001835-0s7ok4uw	5800	10	Lipid	Lipid	NNP
cord-001835-0s7ok4uw	5800	11	Vesicles	Vesicles	NNP
cord-001835-0s7ok4uw	5800	12	and	and	CC
cord-001835-0s7ok4uw	5800	13	Its	-PRON-	PRP$
cord-001835-0s7ok4uw	5800	14	Relationship	relationship	NN
cord-001835-0s7ok4uw	5800	15	to	to	IN
cord-001835-0s7ok4uw	5800	16	Antimicrobial	Antimicrobial	NNP
cord-001835-0s7ok4uw	5800	17	Activity	Activity	NNP
cord-001835-0s7ok4uw	5800	18	Self	Self	NNP
cord-001835-0s7ok4uw	5800	19	-	-	HYPH
cord-001835-0s7ok4uw	5800	20	Assembled	assemble	VBN
cord-001835-0s7ok4uw	5800	21	Arginine	Arginine	NNP
cord-001835-0s7ok4uw	5800	22	-	-	HYPH
cord-001835-0s7ok4uw	5800	23	Coated	Coated	NNP
cord-001835-0s7ok4uw	5800	24	Peptide	Peptide	NNP
cord-001835-0s7ok4uw	5800	25	Nanosheets	Nanosheets	NNPS
cord-001835-0s7ok4uw	5800	26	in	in	IN
cord-001835-0s7ok4uw	5800	27	Water	Water	NNP
cord-001835-0s7ok4uw	5800	28	Toll	Toll	NNP
cord-001835-0s7ok4uw	5800	29	-	-	HYPH
cord-001835-0s7ok4uw	5800	30	like	like	JJ
cord-001835-0s7ok4uw	5801	1	Receptor	Receptor	NNP
cord-001835-0s7ok4uw	5801	2	Agonist	Agonist	NNP
cord-001835-0s7ok4uw	5801	3	Lipopeptides	Lipopeptides	NNP
cord-001835-0s7ok4uw	5801	4	Self	Self	NNP
cord-001835-0s7ok4uw	5801	5	-	-	HYPH
cord-001835-0s7ok4uw	5801	6	Assemble	Assemble	NNP
cord-001835-0s7ok4uw	5801	7	into	into	IN
cord-001835-0s7ok4uw	5801	8	Distinct	distinct	JJ
cord-001835-0s7ok4uw	5801	9	Nanostructures	Nanostructures	NNPS
cord-001835-0s7ok4uw	5801	10	Approved	approve	VBN
cord-001835-0s7ok4uw	5801	11	Drugs	drug	NNS
cord-001835-0s7ok4uw	5801	12	containing	contain	VBG
cord-001835-0s7ok4uw	5801	13	Thiols	Thiols	NNP
cord-001835-0s7ok4uw	5801	14	as	as	IN
cord-001835-0s7ok4uw	5801	15	Inhibitors	Inhibitors	NNP
cord-001835-0s7ok4uw	5801	16	of	of	IN
cord-001835-0s7ok4uw	5801	17	Metallo	Metallo	NNP
cord-001835-0s7ok4uw	5801	18	-	-	HYPH
cord-001835-0s7ok4uw	5801	19	ß	ß	NNP
cord-001835-0s7ok4uw	5801	20	-	-	HYPH
cord-001835-0s7ok4uw	5801	21	Lactamases	Lactamases	NNP
cord-001835-0s7ok4uw	5801	22	:	:	:
cord-001835-0s7ok4uw	5802	1	A	a	DT
cord-001835-0s7ok4uw	5802	2	Strategy	Strategy	NNP
cord-001835-0s7ok4uw	5802	3	to	to	TO
cord-001835-0s7ok4uw	5802	4	Combat	Combat	NNP
cord-001835-0s7ok4uw	5802	5	Multidrug	Multidrug	NNP
cord-001835-0s7ok4uw	5802	6	-	-	HYPH
cord-001835-0s7ok4uw	5802	7	Resistant	resistant	JJ
cord-001835-0s7ok4uw	5802	8	Bacteria	Bacteria	NNS
cord-001835-0s7ok4uw	5803	1	References	References	NNPS
cord-001835-0s7ok4uw	5803	2	Leukotriene	Leukotriene	NNP
cord-001835-0s7ok4uw	5803	3	A4	A4	NNP
cord-001835-0s7ok4uw	5803	4	Hydrolase	Hydrolase	NNP
cord-001835-0s7ok4uw	5803	5	-An	-An	NNP
cord-001835-0s7ok4uw	5803	6	envolving	envolve	VBG
cord-001835-0s7ok4uw	5803	7	target	target	NN
cord-001835-0s7ok4uw	5803	8	.	.	.
cord-001835-0s7ok4uw	5804	1	Inflammatory	inflammatory	JJ
cord-001835-0s7ok4uw	5804	2	Diseases	Diseases	NNPS
cord-001835-0s7ok4uw	5804	3	-Immunopathology	-immunopathology	NN
cord-001835-0s7ok4uw	5804	4	,	,	,
cord-001835-0s7ok4uw	5804	5	Clinical	clinical	JJ
cord-001835-0s7ok4uw	5804	6	and	and	CC
cord-001835-0s7ok4uw	5804	7	Pharmacological	pharmacological	JJ
cord-001835-0s7ok4uw	5804	8	Bases	Bases	NNPS
cord-001835-0s7ok4uw	5805	1	The	the	DT
cord-001835-0s7ok4uw	5805	2	Bifunctional	Bifunctional	NNP
cord-001835-0s7ok4uw	5805	3	Enzyme	Enzyme	NNP
cord-001835-0s7ok4uw	5805	4	Leukotriene	Leukotriene	NNP
cord-001835-0s7ok4uw	5805	5	-	-	HYPH
cord-001835-0s7ok4uw	5805	6	A	A	NNP
cord-001835-0s7ok4uw	5805	7	,	,	,
cord-001835-0s7ok4uw	5805	8	Hydrolase	Hydrolase	NNP
cord-001835-0s7ok4uw	5805	9	Is	be	VBZ
cord-001835-0s7ok4uw	5805	10	an	an	DT
cord-001835-0s7ok4uw	5805	11	Arginine	Arginine	NNP
cord-001835-0s7ok4uw	5805	12	Aminopeptidase	Aminopeptidase	NNP
cord-001835-0s7ok4uw	5805	13	of	of	IN
cord-001835-0s7ok4uw	5805	14	High	High	NNP
cord-001835-0s7ok4uw	5805	15	Efficiency	Efficiency	NNP
cord-001835-0s7ok4uw	5805	16	and	and	CC
cord-001835-0s7ok4uw	5805	17	Specificity	Specificity	NNP
cord-001835-0s7ok4uw	5805	18	Lipoxygenase	Lipoxygenase	NNP
cord-001835-0s7ok4uw	5805	19	and	and	CC
cord-001835-0s7ok4uw	5805	20	Leukotriene	Leukotriene	NNP
cord-001835-0s7ok4uw	5805	21	Pathways	Pathways	NNPS
cord-001835-0s7ok4uw	5805	22	:	:	:
cord-001835-0s7ok4uw	5805	23	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	5805	24	,	,	,
cord-001835-0s7ok4uw	5805	25	Biology	biology	NN
cord-001835-0s7ok4uw	5805	26	,	,	,
cord-001835-0s7ok4uw	5805	27	and	and	CC
cord-001835-0s7ok4uw	5805	28	Roles	Roles	NNPS
cord-001835-0s7ok4uw	5805	29	in	in	IN
cord-001835-0s7ok4uw	5805	30	Disease	Disease	NNP
cord-001835-0s7ok4uw	5805	31	A	a	DT
cord-001835-0s7ok4uw	5805	32	critical	critical	JJ
cord-001835-0s7ok4uw	5805	33	role	role	NN
cord-001835-0s7ok4uw	5805	34	for	for	IN
cord-001835-0s7ok4uw	5805	35	LTA4H	lta4h	NN
cord-001835-0s7ok4uw	5805	36	in	in	IN
cord-001835-0s7ok4uw	5805	37	limiting	limit	VBG
cord-001835-0s7ok4uw	5805	38	chronic	chronic	JJ
cord-001835-0s7ok4uw	5805	39	pulmonary	pulmonary	NN
cord-001835-0s7ok4uw	5806	1	This	this	DT
cord-001835-0s7ok4uw	5806	2	work	work	NN
cord-001835-0s7ok4uw	5806	3	was	be	VBD
cord-001835-0s7ok4uw	5806	4	supported	support	VBN
cord-001835-0s7ok4uw	5806	5	by	by	IN
cord-001835-0s7ok4uw	5806	6	the	the	DT
cord-001835-0s7ok4uw	5806	7	Czech	Czech	NNP
cord-001835-0s7ok4uw	5806	8	Science	Science	NNP
cord-001835-0s7ok4uw	5806	9	Foundation	Foundation	NNP
cord-001835-0s7ok4uw	5806	10	(	(	-LRB-
cord-001835-0s7ok4uw	5806	11	Project	Project	NNP
cord-001835-0s7ok4uw	5806	12	P305/11/0708	p305/11/0708	CD
cord-001835-0s7ok4uw	5806	13	)	)	-RRB-
cord-001835-0s7ok4uw	5806	14	and	and	CC
cord-001835-0s7ok4uw	5806	15	Czech	Czech	NNP
cord-001835-0s7ok4uw	5806	16	Academy	Academy	NNP
cord-001835-0s7ok4uw	5806	17	of	of	IN
cord-001835-0s7ok4uw	5806	18	Sciences	Sciences	NNPS
cord-001835-0s7ok4uw	5806	19	The	the	DT
cord-001835-0s7ok4uw	5806	20	Tn	Tn	NNP
cord-001835-0s7ok4uw	5806	21	antigen	antigen	NN
cord-001835-0s7ok4uw	5806	22	-	-	HYPH
cord-001835-0s7ok4uw	5806	23	structural	structural	JJ
cord-001835-0s7ok4uw	5806	24	simplicity	simplicity	NN
cord-001835-0s7ok4uw	5806	25	and	and	CC
cord-001835-0s7ok4uw	5806	26	biological	biological	JJ
cord-001835-0s7ok4uw	5806	27	complexity	complexity	NN
cord-001835-0s7ok4uw	5806	28	BEL	BEL	NNP
cord-001835-0s7ok4uw	5806	29	b	b	NNP
cord-001835-0s7ok4uw	5806	30	-	-	HYPH
cord-001835-0s7ok4uw	5806	31	trefoil	trefoil	NNP
cord-001835-0s7ok4uw	5806	32	:	:	:
cord-001835-0s7ok4uw	5806	33	a	a	DT
cord-001835-0s7ok4uw	5806	34	novel	novel	JJ
cord-001835-0s7ok4uw	5806	35	lectin	lectin	NN
cord-001835-0s7ok4uw	5806	36	with	with	IN
cord-001835-0s7ok4uw	5806	37	antineoplastic	antineoplastic	JJ
cord-001835-0s7ok4uw	5806	38	properties	property	NNS
cord-001835-0s7ok4uw	5806	39	in	in	IN
cord-001835-0s7ok4uw	5806	40	king	king	NN
cord-001835-0s7ok4uw	5806	41	bolete	bolete	NN
cord-001835-0s7ok4uw	5806	42	(	(	-LRB-
cord-001835-0s7ok4uw	5806	43	Boletus	boletus	FW
cord-001835-0s7ok4uw	5806	44	edulis	edulis	NN
cord-001835-0s7ok4uw	5806	45	)	)	-RRB-
cord-001835-0s7ok4uw	5807	1	mushrooms	mushroom	NNS
cord-001835-0s7ok4uw	5807	2	Acknowledgements	acknowledgement	NNS
cord-001835-0s7ok4uw	5807	3	:	:	:
cord-001835-0s7ok4uw	5808	1	Cynthia	Cynthia	NNP
cord-001835-0s7ok4uw	5808	2	Leyva	Leyva	NNP
cord-001835-0s7ok4uw	5808	3	-	-	HYPH
cord-001835-0s7ok4uw	5808	4	Arg€	Arg€	NNP
cord-001835-0s7ok4uw	5808	5	uelles	uelle	NNS
cord-001835-0s7ok4uw	5808	6	is	be	VBZ
cord-001835-0s7ok4uw	5808	7	supported	support	VBN
cord-001835-0s7ok4uw	5808	8	by	by	IN
cord-001835-0s7ok4uw	5808	9	a	a	DT
cord-001835-0s7ok4uw	5808	10	personal	personal	JJ
cord-001835-0s7ok4uw	5808	11	grant	grant	NN
cord-001835-0s7ok4uw	5808	12	from	from	IN
cord-001835-0s7ok4uw	5808	13	CONACyT	CONACyT	NNP
cord-001835-0s7ok4uw	5808	14	,	,	,
cord-001835-0s7ok4uw	5808	15	Mexico	Mexico	NNP
cord-001835-0s7ok4uw	5808	16	.	.	.
cord-001835-0s7ok4uw	5809	1	This	this	DT
cord-001835-0s7ok4uw	5809	2	work	work	NN
cord-001835-0s7ok4uw	5809	3	is	be	VBZ
cord-001835-0s7ok4uw	5809	4	supported	support	VBN
cord-001835-0s7ok4uw	5809	5	by	by	IN
cord-001835-0s7ok4uw	5809	6	CONACYT	CONACYT	NNP
cord-001835-0s7ok4uw	5809	7	grant	grant	NN
cord-001835-0s7ok4uw	5809	8	131'06:15	131'06:15	NNP
cord-001835-0s7ok4uw	5809	9	and	and	CC
cord-001835-0s7ok4uw	5809	10	PAPIIT	PAPIIT	NNP
cord-001835-0s7ok4uw	5810	1	grant	grant	NNP
cord-001835-0s7ok4uw	5810	2	IN218714	IN218714	NNP
cord-001835-0s7ok4uw	5810	3	Sequence	Sequence	NNP
cord-001835-0s7ok4uw	5810	4	information	information	NN
cord-001835-0s7ok4uw	5810	5	-	-	HYPH
cord-001835-0s7ok4uw	5810	6	based	base	VBN
cord-001835-0s7ok4uw	5810	7	deciphering	deciphering	NN
cord-001835-0s7ok4uw	5810	8	of	of	IN
cord-001835-0s7ok4uw	5810	9	biofunctionalities	biofunctionalitie	NNS
cord-001835-0s7ok4uw	5810	10	using	use	VBG
cord-001835-0s7ok4uw	5810	11	ISM	ism	NN
cord-001835-0s7ok4uw	5810	12	-	-	HYPH
cord-001835-0s7ok4uw	5810	13	based	base	VBN
cord-001835-0s7ok4uw	5810	14	techniques	technique	NNS
cord-001835-0s7ok4uw	5810	15	has	have	VBZ
cord-001835-0s7ok4uw	5810	16	fetched	fetch	VBN
cord-001835-0s7ok4uw	5810	17	calculation	calculation	NN
cord-001835-0s7ok4uw	5810	18	of	of	IN
cord-001835-0s7ok4uw	5810	19	biological	biological	JJ
cord-001835-0s7ok4uw	5810	20	functionalities	functionality	NNS
cord-001835-0s7ok4uw	5810	21	,	,	,
cord-001835-0s7ok4uw	5810	22	designing	design	VBG
cord-001835-0s7ok4uw	5810	23	of	of	IN
cord-001835-0s7ok4uw	5810	24	biomedical	biomedical	JJ
cord-001835-0s7ok4uw	5810	25	device	device	NN
cord-001835-0s7ok4uw	5810	26	called	call	VBN
cord-001835-0s7ok4uw	5810	27	Computer	Computer	NNP
cord-001835-0s7ok4uw	5810	28	-	-	HYPH
cord-001835-0s7ok4uw	5810	29	Aided	Aided	NNP
cord-001835-0s7ok4uw	5810	30	Drug	Drug	NNP
cord-001835-0s7ok4uw	5810	31	Resistance	Resistance	NNP
cord-001835-0s7ok4uw	5810	32	Calculator	Calculator	NNP
cord-001835-0s7ok4uw	5810	33	,	,	,
cord-001835-0s7ok4uw	5810	34	the	the	DT
cord-001835-0s7ok4uw	5810	35	understanding	understanding	NN
cord-001835-0s7ok4uw	5810	36	of	of	IN
cord-001835-0s7ok4uw	5810	37	the	the	DT
cord-001835-0s7ok4uw	5810	38	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5810	39	of	of	IN
cord-001835-0s7ok4uw	5810	40	HIV	HIV	NNP
cord-001835-0s7ok4uw	5810	41	progression	progression	NN
cord-001835-0s7ok4uw	5810	42	to	to	IN
cord-001835-0s7ok4uw	5810	43	AIDS	AIDS	NNP
cord-001835-0s7ok4uw	5810	44	[	[	-LRB-
cord-001835-0s7ok4uw	5810	45	4	4	CD
cord-001835-0s7ok4uw	5810	46	]	]	-RRB-
cord-001835-0s7ok4uw	5810	47	,	,	,
cord-001835-0s7ok4uw	5810	48	and	and	CC
cord-001835-0s7ok4uw	5810	49	others	other	NNS
cord-001835-0s7ok4uw	5810	50	.	.	.
cord-001835-0s7ok4uw	5811	1	They	-PRON-	PRP
cord-001835-0s7ok4uw	5811	2	have	have	VBP
cord-001835-0s7ok4uw	5811	3	compared	compare	VBN
cord-001835-0s7ok4uw	5811	4	the	the	DT
cord-001835-0s7ok4uw	5811	5	efficacies	efficacy	NNS
cord-001835-0s7ok4uw	5811	6	of	of	IN
cord-001835-0s7ok4uw	5811	7	drugs	drug	NNS
cord-001835-0s7ok4uw	5811	8	and	and	CC
cord-001835-0s7ok4uw	5811	9	vaccines	vaccine	NNS
cord-001835-0s7ok4uw	5811	10	,	,	,
cord-001835-0s7ok4uw	5811	11	which	which	WDT
cord-001835-0s7ok4uw	5811	12	formed	form	VBD
cord-001835-0s7ok4uw	5811	13	the	the	DT
cord-001835-0s7ok4uw	5811	14	basis	basis	NN
cord-001835-0s7ok4uw	5811	15	for	for	IN
cord-001835-0s7ok4uw	5811	16	the	the	DT
cord-001835-0s7ok4uw	5811	17	Innocentive	Innocentive	NNP
cord-001835-0s7ok4uw	5811	18	Award	Award	NNP
cord-001835-0s7ok4uw	5811	19	(	(	-LRB-
cord-001835-0s7ok4uw	5811	20	ID	ID	NNP
cord-001835-0s7ok4uw	5811	21	9933477	9933477	CD
cord-001835-0s7ok4uw	5811	22	)	)	-RRB-
cord-001835-0s7ok4uw	5811	23	for	for	IN
cord-001835-0s7ok4uw	5811	24	Assessing	Assessing	NNP
cord-001835-0s7ok4uw	5811	25	Vaccine	Vaccine	NNP
cord-001835-0s7ok4uw	5811	26	Potency	Potency	NNP
cord-001835-0s7ok4uw	5811	27	.	.	.
cord-001835-0s7ok4uw	5812	1	Conclusions	conclusion	NNS
cord-001835-0s7ok4uw	5812	2	:	:	:
cord-001835-0s7ok4uw	5813	1	Deciphering	decipher	VBG
cord-001835-0s7ok4uw	5813	2	biological	biological	JJ
cord-001835-0s7ok4uw	5813	3	features	feature	NNS
cord-001835-0s7ok4uw	5813	4	without	without	IN
cord-001835-0s7ok4uw	5813	5	engaging	engage	VBG
cord-001835-0s7ok4uw	5813	6	reagents	reagent	NNS
cord-001835-0s7ok4uw	5813	7	,	,	,
cord-001835-0s7ok4uw	5813	8	equipments	equipment	NNS
cord-001835-0s7ok4uw	5813	9	and	and	CC
cord-001835-0s7ok4uw	5813	10	animal	animal	NN
cord-001835-0s7ok4uw	5813	11	tissues	tissue	NNS
cord-001835-0s7ok4uw	5813	12	but	but	CC
cord-001835-0s7ok4uw	5813	13	biological	biological	JJ
cord-001835-0s7ok4uw	5813	14	data	datum	NNS
cord-001835-0s7ok4uw	5813	15	such	such	JJ
cord-001835-0s7ok4uw	5813	16	as	as	IN
cord-001835-0s7ok4uw	5813	17	sequence	sequence	NN
cord-001835-0s7ok4uw	5813	18	information	information	NN
cord-001835-0s7ok4uw	5813	19	is	be	VBZ
cord-001835-0s7ok4uw	5813	20	one	one	CD
cord-001835-0s7ok4uw	5813	21	novel	novel	NN
cord-001835-0s7ok4uw	5813	22	,	,	,
cord-001835-0s7ok4uw	5813	23	feasible	feasible	JJ
cord-001835-0s7ok4uw	5813	24	Genotypic	Genotypic	NNP
cord-001835-0s7ok4uw	5813	25	HIV	HIV	NNP
cord-001835-0s7ok4uw	5813	26	-	-	HYPH
cord-001835-0s7ok4uw	5813	27	coreceptor	coreceptor	NNP
cord-001835-0s7ok4uw	5813	28	tropism	tropism	NN
cord-001835-0s7ok4uw	5813	29	prediction	prediction	NN
cord-001835-0s7ok4uw	5813	30	with	with	IN
cord-001835-0s7ok4uw	5813	31	geno2pheno	geno2pheno	NNP
cord-001835-0s7ok4uw	5813	32	[	[	-LRB-
cord-001835-0s7ok4uw	5813	33	CORECEPTOR	CORECEPTOR	NNP
cord-001835-0s7ok4uw	5813	34	]	]	-RRB-
cord-001835-0s7ok4uw	5813	35	:	:	:
cord-001835-0s7ok4uw	5813	36	differences	difference	NNS
cord-001835-0s7ok4uw	5813	37	depending	depend	VBG
cord-001835-0s7ok4uw	5813	38	on	on	IN
cord-001835-0s7ok4uw	5813	39	HIV-1	HIV-1	NNP
cord-001835-0s7ok4uw	5813	40	subtype	subtype	NN
cord-001835-0s7ok4uw	5813	41	A	a	DT
cord-001835-0s7ok4uw	5813	42	reliable	reliable	JJ
cord-001835-0s7ok4uw	5813	43	phenotype	phenotype	NN
cord-001835-0s7ok4uw	5813	44	predictor	predictor	NN
cord-001835-0s7ok4uw	5813	45	for	for	IN
cord-001835-0s7ok4uw	5813	46	human	human	JJ
cord-001835-0s7ok4uw	5813	47	immunodeficiency	immunodeficiency	NN
cord-001835-0s7ok4uw	5813	48	virus	virus	NN
cord-001835-0s7ok4uw	5813	49	type	type	NN
cord-001835-0s7ok4uw	5813	50	1	1	CD
cord-001835-0s7ok4uw	5813	51	subtype	subtype	NN
cord-001835-0s7ok4uw	5813	52	C	c	NN
cord-001835-0s7ok4uw	5813	53	based	base	VBN
cord-001835-0s7ok4uw	5813	54	on	on	IN
cord-001835-0s7ok4uw	5813	55	Envelope	envelope	NN
cord-001835-0s7ok4uw	5813	56	V3	v3	NN
cord-001835-0s7ok4uw	5813	57	sequences	sequence	NNS
cord-001835-0s7ok4uw	5814	1	Available	available	JJ
cord-001835-0s7ok4uw	5814	2	:	:	:
cord-001835-0s7ok4uw	5815	1	http://	http://	NNP
cord-001835-0s7ok4uw	5815	2	istree.bioprotection.org	istree.bioprotection.org	NNP
cord-001835-0s7ok4uw	5815	3	Signal	Signal	NNP
cord-001835-0s7ok4uw	5815	4	processing	processing	NN
cord-001835-0s7ok4uw	5815	5	-	-	HYPH
cord-001835-0s7ok4uw	5815	6	based	base	VBN
cord-001835-0s7ok4uw	5815	7	Bioinformatics	Bioinformatics	NNP
cord-001835-0s7ok4uw	5815	8	methods	method	NNS
cord-001835-0s7ok4uw	5815	9	for	for	IN
cord-001835-0s7ok4uw	5815	10	characterization	characterization	NN
cord-001835-0s7ok4uw	5815	11	and	and	CC
cord-001835-0s7ok4uw	5815	12	identification	identification	NN
cord-001835-0s7ok4uw	5815	13	of	of	IN
cord-001835-0s7ok4uw	5815	14	Bio	Bio	NNP
cord-001835-0s7ok4uw	5815	15	-	-	HYPH
cord-001835-0s7ok4uw	5815	16	functionalities	functionality	NNS
cord-001835-0s7ok4uw	5815	17	of	of	IN
cord-001835-0s7ok4uw	5815	18	proteins	protein	NNS
cord-001835-0s7ok4uw	5816	1	An	an	DT
cord-001835-0s7ok4uw	5816	2	empirical	empirical	JJ
cord-001835-0s7ok4uw	5816	3	framework	framework	NN
cord-001835-0s7ok4uw	5816	4	for	for	IN
cord-001835-0s7ok4uw	5816	5	binary	binary	JJ
cord-001835-0s7ok4uw	5816	6	interactome	interactome	NNP
cord-001835-0s7ok4uw	5816	7	mapping	mapping	NN
cord-001835-0s7ok4uw	5816	8	Estimating	estimate	VBG
cord-001835-0s7ok4uw	5816	9	the	the	DT
cord-001835-0s7ok4uw	5816	10	size	size	NN
cord-001835-0s7ok4uw	5816	11	of	of	IN
cord-001835-0s7ok4uw	5816	12	the	the	DT
cord-001835-0s7ok4uw	5816	13	human	human	JJ
cord-001835-0s7ok4uw	5816	14	interactome	interactome	NN
cord-001835-0s7ok4uw	5816	15	Coming	come	VBG
cord-001835-0s7ok4uw	5816	16	to	to	IN
cord-001835-0s7ok4uw	5816	17	peace	peace	NN
cord-001835-0s7ok4uw	5816	18	with	with	IN
cord-001835-0s7ok4uw	5816	19	protein	protein	NN
cord-001835-0s7ok4uw	5816	20	complexes	complex	NNS
cord-001835-0s7ok4uw	5816	21	?	?	.
cord-001835-0s7ok4uw	5817	1	5th	5th	JJ
cord-001835-0s7ok4uw	5817	2	CAPRI	CAPRI	NNP
cord-001835-0s7ok4uw	5817	3	evaluation	evaluation	NN
cord-001835-0s7ok4uw	5817	4	meeting	meeting	NN
cord-001835-0s7ok4uw	5817	5	PJ-022	PJ-022	NNP
cord-001835-0s7ok4uw	5817	6	CABS	cab	NNS
cord-001835-0s7ok4uw	5817	7	-	-	HYPH
cord-001835-0s7ok4uw	5817	8	dock	dock	NN
cord-001835-0s7ok4uw	5817	9	web	web	NN
cord-001835-0s7ok4uw	5817	10	server	server	NN
cord-001835-0s7ok4uw	5817	11	for	for	IN
cord-001835-0s7ok4uw	5817	12	protein	protein	NN
cord-001835-0s7ok4uw	5817	13	-	-	HYPH
cord-001835-0s7ok4uw	5817	14	peptide	peptide	NN
cord-001835-0s7ok4uw	5817	15	docking	docking	NN
cord-001835-0s7ok4uw	5817	16	with	with	IN
cord-001835-0s7ok4uw	5817	17	significant	significant	JJ
cord-001835-0s7ok4uw	5817	18	conformational	conformational	JJ
cord-001835-0s7ok4uw	5817	19	changes	change	NNS
cord-001835-0s7ok4uw	5817	20	and	and	CC
cord-001835-0s7ok4uw	5817	21	without	without	IN
cord-001835-0s7ok4uw	5817	22	prior	prior	JJ
cord-001835-0s7ok4uw	5817	23	knowledge	knowledge	NN
cord-001835-0s7ok4uw	5817	24	of	of	IN
cord-001835-0s7ok4uw	5817	25	the	the	DT
cord-001835-0s7ok4uw	5817	26	binding	binding	NN
cord-001835-0s7ok4uw	5817	27	site	site	NN
cord-001835-0s7ok4uw	5818	1	While	while	IN
cord-001835-0s7ok4uw	5818	2	other	other	JJ
cord-001835-0s7ok4uw	5818	3	docking	docking	NN
cord-001835-0s7ok4uw	5818	4	algorithms	algorithm	NNS
cord-001835-0s7ok4uw	5818	5	require	require	VBP
cord-001835-0s7ok4uw	5818	6	pre	pre	JJ
cord-001835-0s7ok4uw	5818	7	-	-	JJ
cord-001835-0s7ok4uw	5818	8	defined	defined	JJ
cord-001835-0s7ok4uw	5818	9	localization	localization	NN
cord-001835-0s7ok4uw	5818	10	of	of	IN
cord-001835-0s7ok4uw	5818	11	the	the	DT
cord-001835-0s7ok4uw	5818	12	binding	binding	NN
cord-001835-0s7ok4uw	5818	13	site	site	NN
cord-001835-0s7ok4uw	5818	14	,	,	,
cord-001835-0s7ok4uw	5818	15	CABS	cab	NNS
cord-001835-0s7ok4uw	5818	16	-	-	:
cord-001835-0s7ok4uw	5818	17	dock	dock	NN
cord-001835-0s7ok4uw	5818	18	does	do	VBZ
cord-001835-0s7ok4uw	5818	19	n't	not	RB
cord-001835-0s7ok4uw	5818	20	require	require	VB
cord-001835-0s7ok4uw	5818	21	such	such	JJ
cord-001835-0s7ok4uw	5818	22	knowledge	knowledge	NN
cord-001835-0s7ok4uw	5818	23	.	.	.
cord-001835-0s7ok4uw	5819	1	Given	give	VBN
cord-001835-0s7ok4uw	5819	2	a	a	DT
cord-001835-0s7ok4uw	5819	3	protein	protein	NN
cord-001835-0s7ok4uw	5819	4	receptor	receptor	NN
cord-001835-0s7ok4uw	5819	5	structure	structure	NN
cord-001835-0s7ok4uw	5819	6	and	and	CC
cord-001835-0s7ok4uw	5819	7	a	a	DT
cord-001835-0s7ok4uw	5819	8	peptide	peptide	NN
cord-001835-0s7ok4uw	5819	9	sequence	sequence	NN
cord-001835-0s7ok4uw	5819	10	(	(	-LRB-
cord-001835-0s7ok4uw	5819	11	and	and	CC
cord-001835-0s7ok4uw	5819	12	starting	start	VBG
cord-001835-0s7ok4uw	5819	13	from	from	IN
cord-001835-0s7ok4uw	5819	14	random	random	JJ
cord-001835-0s7ok4uw	5819	15	conformations	conformation	NNS
cord-001835-0s7ok4uw	5819	16	and	and	CC
cord-001835-0s7ok4uw	5819	17	positions	position	NNS
cord-001835-0s7ok4uw	5819	18	of	of	IN
cord-001835-0s7ok4uw	5819	19	the	the	DT
cord-001835-0s7ok4uw	5819	20	peptide	peptide	NN
cord-001835-0s7ok4uw	5819	21	)	)	-RRB-
cord-001835-0s7ok4uw	5819	22	,	,	,
cord-001835-0s7ok4uw	5819	23	CABS	cab	NNS
cord-001835-0s7ok4uw	5819	24	-	-	HYPH
cord-001835-0s7ok4uw	5819	25	dock	dock	NN
cord-001835-0s7ok4uw	5819	26	performs	perform	VBZ
cord-001835-0s7ok4uw	5819	27	simulation	simulation	NN
cord-001835-0s7ok4uw	5819	28	search	search	NN
cord-001835-0s7ok4uw	5819	29	for	for	IN
cord-001835-0s7ok4uw	5819	30	the	the	DT
cord-001835-0s7ok4uw	5819	31	binding	binding	NN
cord-001835-0s7ok4uw	5819	32	site	site	NN
cord-001835-0s7ok4uw	5819	33	allowing	allow	VBG
cord-001835-0s7ok4uw	5819	34	for	for	IN
cord-001835-0s7ok4uw	5819	35	full	full	JJ
cord-001835-0s7ok4uw	5819	36	flexibility	flexibility	NN
cord-001835-0s7ok4uw	5819	37	of	of	IN
cord-001835-0s7ok4uw	5819	38	the	the	DT
cord-001835-0s7ok4uw	5819	39	peptide	peptide	JJ
cord-001835-0s7ok4uw	5819	40	and	and	CC
cord-001835-0s7ok4uw	5819	41	small	small	JJ
cord-001835-0s7ok4uw	5819	42	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	5819	43	of	of	IN
cord-001835-0s7ok4uw	5819	44	the	the	DT
cord-001835-0s7ok4uw	5819	45	receptor	receptor	NN
cord-001835-0s7ok4uw	5819	46	backbone	backbone	NN
cord-001835-0s7ok4uw	5819	47	CABS	cab	NNS
cord-001835-0s7ok4uw	5819	48	-	-	:
cord-001835-0s7ok4uw	5819	49	flex	flex	JJ
cord-001835-0s7ok4uw	5819	50	:	:	:
cord-001835-0s7ok4uw	5819	51	Server	server	NN
cord-001835-0s7ok4uw	5819	52	for	for	IN
cord-001835-0s7ok4uw	5819	53	fast	fast	JJ
cord-001835-0s7ok4uw	5819	54	simulation	simulation	NN
cord-001835-0s7ok4uw	5819	55	of	of	IN
cord-001835-0s7ok4uw	5819	56	protein	protein	NN
cord-001835-0s7ok4uw	5819	57	structure	structure	NN
cord-001835-0s7ok4uw	5819	58	fluctuations	fluctuation	NNS
cord-001835-0s7ok4uw	5819	59	CABS	cab	NNS
cord-001835-0s7ok4uw	5819	60	-	-	:
cord-001835-0s7ok4uw	5819	61	fold	fold	RB
cord-001835-0s7ok4uw	5819	62	:	:	:
cord-001835-0s7ok4uw	5819	63	Server	server	NN
cord-001835-0s7ok4uw	5819	64	for	for	IN
cord-001835-0s7ok4uw	5819	65	the	the	DT
cord-001835-0s7ok4uw	5819	66	de	de	FW
cord-001835-0s7ok4uw	5819	67	novo	novo	NNP
cord-001835-0s7ok4uw	5819	68	and	and	CC
cord-001835-0s7ok4uw	5819	69	consensus	consensus	NN
cord-001835-0s7ok4uw	5819	70	-	-	HYPH
cord-001835-0s7ok4uw	5819	71	based	base	VBN
cord-001835-0s7ok4uw	5819	72	prediction	prediction	NN
cord-001835-0s7ok4uw	5819	73	of	of	IN
cord-001835-0s7ok4uw	5819	74	protein	protein	NN
cord-001835-0s7ok4uw	5819	75	structure	structure	NN
cord-001835-0s7ok4uw	5819	76	CABS	cab	NNS
cord-001835-0s7ok4uw	5819	77	-	-	HYPH
cord-001835-0s7ok4uw	5819	78	dock	dock	NN
cord-001835-0s7ok4uw	5819	79	web	web	NN
cord-001835-0s7ok4uw	5819	80	server	server	NN
cord-001835-0s7ok4uw	5819	81	for	for	IN
cord-001835-0s7ok4uw	5819	82	the	the	DT
cord-001835-0s7ok4uw	5819	83	flexible	flexible	JJ
cord-001835-0s7ok4uw	5819	84	docking	docking	NN
cord-001835-0s7ok4uw	5819	85	of	of	IN
cord-001835-0s7ok4uw	5819	86	peptides	peptide	NNS
cord-001835-0s7ok4uw	5819	87	to	to	IN
cord-001835-0s7ok4uw	5819	88	proteins	protein	NNS
cord-001835-0s7ok4uw	5819	89	without	without	IN
cord-001835-0s7ok4uw	5819	90	prior	prior	JJ
cord-001835-0s7ok4uw	5819	91	knowledge	knowledge	NN
cord-001835-0s7ok4uw	5819	92	of	of	IN
cord-001835-0s7ok4uw	5819	93	the	the	DT
cord-001835-0s7ok4uw	5819	94	binding	binding	NN
cord-001835-0s7ok4uw	5819	95	site	site	NN
cord-001835-0s7ok4uw	5819	96	Mechanism	Mechanism	NNP
cord-001835-0s7ok4uw	5819	97	of	of	IN
cord-001835-0s7ok4uw	5819	98	Folding	Folding	NNP
cord-001835-0s7ok4uw	5819	99	and	and	CC
cord-001835-0s7ok4uw	5819	100	Binding	Binding	NNP
cord-001835-0s7ok4uw	5819	101	of	of	IN
cord-001835-0s7ok4uw	5819	102	an	an	DT
cord-001835-0s7ok4uw	5819	103	Intrinsically	intrinsically	RB
cord-001835-0s7ok4uw	5819	104	Disordered	disordered	JJ
cord-001835-0s7ok4uw	5819	105	Protein	protein	NN
cord-001835-0s7ok4uw	5820	1	As	as	IN
cord-001835-0s7ok4uw	5820	2	Revealed	reveal	VBN
cord-001835-0s7ok4uw	5820	3	by	by	IN
cord-001835-0s7ok4uw	5820	4	ab	ab	NNP
cord-001835-0s7ok4uw	5820	5	Initio	Initio	NNP
cord-001835-0s7ok4uw	5820	6	Simulations	Simulations	NNPS
cord-001835-0s7ok4uw	5820	7	Modeling	Modeling	NNP
cord-001835-0s7ok4uw	5820	8	of	of	IN
cord-001835-0s7ok4uw	5820	9	protein	protein	NN
cord-001835-0s7ok4uw	5820	10	-	-	HYPH
cord-001835-0s7ok4uw	5820	11	peptide	peptide	NN
cord-001835-0s7ok4uw	5820	12	interactions	interaction	NNS
cord-001835-0s7ok4uw	5820	13	using	use	VBG
cord-001835-0s7ok4uw	5820	14	the	the	DT
cord-001835-0s7ok4uw	5820	15	CABS	cab	NNS
cord-001835-0s7ok4uw	5820	16	-	-	HYPH
cord-001835-0s7ok4uw	5820	17	dock	dock	NN
cord-001835-0s7ok4uw	5820	18	web	web	NN
cord-001835-0s7ok4uw	5820	19	server	server	NN
cord-001835-0s7ok4uw	5820	20	for	for	IN
cord-001835-0s7ok4uw	5820	21	binding	bind	VBG
cord-001835-0s7ok4uw	5820	22	site	site	NN
cord-001835-0s7ok4uw	5820	23	search	search	NN
cord-001835-0s7ok4uw	5820	24	and	and	CC
cord-001835-0s7ok4uw	5820	25	flexible	flexible	JJ
cord-001835-0s7ok4uw	5820	26	docking	docking	NN
cord-001835-0s7ok4uw	5821	1	CABS	cab	NNS
cord-001835-0s7ok4uw	5821	2	-	-	:
cord-001835-0s7ok4uw	5821	3	fold	fold	RB
cord-001835-0s7ok4uw	5821	4	:	:	:
cord-001835-0s7ok4uw	5821	5	Server	server	NN
cord-001835-0s7ok4uw	5821	6	for	for	IN
cord-001835-0s7ok4uw	5821	7	the	the	DT
cord-001835-0s7ok4uw	5821	8	de	de	FW
cord-001835-0s7ok4uw	5821	9	novo	novo	NNP
cord-001835-0s7ok4uw	5821	10	and	and	CC
cord-001835-0s7ok4uw	5821	11	consensus	consensus	NN
cord-001835-0s7ok4uw	5821	12	-	-	HYPH
cord-001835-0s7ok4uw	5821	13	based	base	VBN
cord-001835-0s7ok4uw	5821	14	prediction	prediction	NN
cord-001835-0s7ok4uw	5821	15	of	of	IN
cord-001835-0s7ok4uw	5821	16	protein	protein	NN
cord-001835-0s7ok4uw	5821	17	structure	structure	NN
cord-001835-0s7ok4uw	5821	18	CABS	cab	NNS
cord-001835-0s7ok4uw	5821	19	-	-	:
cord-001835-0s7ok4uw	5821	20	flex	flex	JJ
cord-001835-0s7ok4uw	5821	21	:	:	:
cord-001835-0s7ok4uw	5821	22	Server	server	NN
cord-001835-0s7ok4uw	5821	23	for	for	IN
cord-001835-0s7ok4uw	5821	24	fast	fast	JJ
cord-001835-0s7ok4uw	5821	25	simulation	simulation	NN
cord-001835-0s7ok4uw	5821	26	of	of	IN
cord-001835-0s7ok4uw	5822	1	protein	protein	NN
cord-001835-0s7ok4uw	5822	2	structure	structure	NN
cord-001835-0s7ok4uw	5822	3	fluctuations	fluctuation	VBZ
cord-001835-0s7ok4uw	5822	4	AGGRESCAN3D	AGGRESCAN3D	NNP
cord-001835-0s7ok4uw	5822	5	(	(	-LRB-
cord-001835-0s7ok4uw	5822	6	A3D	A3D	NNP
cord-001835-0s7ok4uw	5822	7	)	)	-RRB-
cord-001835-0s7ok4uw	5822	8	:	:	:
cord-001835-0s7ok4uw	5823	1	server	server	NN
cord-001835-0s7ok4uw	5823	2	for	for	IN
cord-001835-0s7ok4uw	5823	3	prediction	prediction	NN
cord-001835-0s7ok4uw	5823	4	of	of	IN
cord-001835-0s7ok4uw	5823	5	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5823	6	properties	property	NNS
cord-001835-0s7ok4uw	5823	7	of	of	IN
cord-001835-0s7ok4uw	5823	8	protein	protein	NN
cord-001835-0s7ok4uw	5823	9	structures	structure	NNS
cord-001835-0s7ok4uw	5823	10	CABS	cab	NNS
cord-001835-0s7ok4uw	5823	11	-	-	HYPH
cord-001835-0s7ok4uw	5823	12	dock	dock	NN
cord-001835-0s7ok4uw	5823	13	web	web	NN
cord-001835-0s7ok4uw	5823	14	server	server	NN
cord-001835-0s7ok4uw	5823	15	for	for	IN
cord-001835-0s7ok4uw	5823	16	the	the	DT
cord-001835-0s7ok4uw	5823	17	flexible	flexible	JJ
cord-001835-0s7ok4uw	5823	18	docking	docking	NN
cord-001835-0s7ok4uw	5823	19	of	of	IN
cord-001835-0s7ok4uw	5823	20	peptides	peptide	NNS
cord-001835-0s7ok4uw	5823	21	to	to	IN
cord-001835-0s7ok4uw	5823	22	proteins	protein	NNS
cord-001835-0s7ok4uw	5823	23	without	without	IN
cord-001835-0s7ok4uw	5823	24	prior	prior	JJ
cord-001835-0s7ok4uw	5823	25	knowledge	knowledge	NN
cord-001835-0s7ok4uw	5823	26	of	of	IN
cord-001835-0s7ok4uw	5823	27	the	the	DT
cord-001835-0s7ok4uw	5823	28	binding	binding	NN
cord-001835-0s7ok4uw	5823	29	site	site	NN
cord-001835-0s7ok4uw	5823	30	Staphylococcal	Staphylococcal	NNP
cord-001835-0s7ok4uw	5823	31	pathogenicity	pathogenicity	NN
cord-001835-0s7ok4uw	5823	32	island	island	NN
cord-001835-0s7ok4uw	5823	33	DNA	dna	NN
cord-001835-0s7ok4uw	5823	34	packaging	packaging	NN
cord-001835-0s7ok4uw	5823	35	system	system	NN
cord-001835-0s7ok4uw	5823	36	involving	involve	VBG
cord-001835-0s7ok4uw	5823	37	cos	cos	NN
cord-001835-0s7ok4uw	5823	38	-	-	HYPH
cord-001835-0s7ok4uw	5823	39	site	site	NN
cord-001835-0s7ok4uw	5823	40	packaging	packaging	NN
cord-001835-0s7ok4uw	5823	41	and	and	CC
cord-001835-0s7ok4uw	5823	42	phage	phage	NN
cord-001835-0s7ok4uw	5823	43	-	-	HYPH
cord-001835-0s7ok4uw	5823	44	encoded	encode	VBN
cord-001835-0s7ok4uw	5823	45	HNH	HNH	NNP
cord-001835-0s7ok4uw	5823	46	endonucleases	endonuclease	NNS
cord-001835-0s7ok4uw	5824	1	The	the	DT
cord-001835-0s7ok4uw	5824	2	etiology	etiology	NN
cord-001835-0s7ok4uw	5824	3	of	of	IN
cord-001835-0s7ok4uw	5824	4	ASDis	ASDis	NNPS
cord-001835-0s7ok4uw	5824	5	unknown	unknown	JJ
cord-001835-0s7ok4uw	5824	6	,	,	,
cord-001835-0s7ok4uw	5824	7	but	but	CC
cord-001835-0s7ok4uw	5824	8	it	-PRON-	PRP
cord-001835-0s7ok4uw	5824	9	is	be	VBZ
cord-001835-0s7ok4uw	5824	10	believed	believe	VBN
cord-001835-0s7ok4uw	5824	11	that	that	IN
cord-001835-0s7ok4uw	5824	12	it	-PRON-	PRP
cord-001835-0s7ok4uw	5824	13	involves	involve	VBZ
cord-001835-0s7ok4uw	5824	14	genetic	genetic	JJ
cord-001835-0s7ok4uw	5824	15	and	and	CC
cord-001835-0s7ok4uw	5824	16	environmental	environmental	JJ
cord-001835-0s7ok4uw	5824	17	components	component	NNS
cord-001835-0s7ok4uw	5824	18	.	.	.
cord-001835-0s7ok4uw	5825	1	The	the	DT
cord-001835-0s7ok4uw	5825	2	purpose	purpose	NN
cord-001835-0s7ok4uw	5825	3	of	of	IN
cord-001835-0s7ok4uw	5825	4	this	this	DT
cord-001835-0s7ok4uw	5825	5	work	work	NN
cord-001835-0s7ok4uw	5825	6	is	be	VBZ
cord-001835-0s7ok4uw	5825	7	to	to	TO
cord-001835-0s7ok4uw	5825	8	assess	assess	VB
cord-001835-0s7ok4uw	5825	9	the	the	DT
cord-001835-0s7ok4uw	5825	10	possible	possible	JJ
cord-001835-0s7ok4uw	5825	11	involvement	involvement	NN
cord-001835-0s7ok4uw	5825	12	of	of	IN
cord-001835-0s7ok4uw	5825	13	food	food	NN
cord-001835-0s7ok4uw	5825	14	contaminants	contaminant	NNS
cord-001835-0s7ok4uw	5825	15	,	,	,
cord-001835-0s7ok4uw	5825	16	such	such	JJ
cord-001835-0s7ok4uw	5825	17	as	as	IN
cord-001835-0s7ok4uw	5825	18	mycotoxins	mycotoxin	NNS
cord-001835-0s7ok4uw	5825	19	,	,	,
cord-001835-0s7ok4uw	5825	20	in	in	IN
cord-001835-0s7ok4uw	5825	21	the	the	DT
cord-001835-0s7ok4uw	5825	22	etiology	etiology	NN
cord-001835-0s7ok4uw	5825	23	of	of	IN
cord-001835-0s7ok4uw	5825	24	ASD	ASD	NNP
cord-001835-0s7ok4uw	5825	25	.	.	.
cord-001835-0s7ok4uw	5826	1	The	the	DT
cord-001835-0s7ok4uw	5826	2	hypothesis	hypothesis	NN
cord-001835-0s7ok4uw	5826	3	is	be	VBZ
cord-001835-0s7ok4uw	5826	4	that	that	IN
cord-001835-0s7ok4uw	5826	5	the	the	DT
cord-001835-0s7ok4uw	5826	6	mycotoxins	mycotoxin	NNS
cord-001835-0s7ok4uw	5826	7	ingested	ingest	VBN
cord-001835-0s7ok4uw	5826	8	with	with	IN
cord-001835-0s7ok4uw	5826	9	the	the	DT
cord-001835-0s7ok4uw	5826	10	diet	diet	NN
cord-001835-0s7ok4uw	5826	11	could	could	MD
cord-001835-0s7ok4uw	5826	12	bind	bind	VB
cord-001835-0s7ok4uw	5826	13	to	to	IN
cord-001835-0s7ok4uw	5826	14	proteins	protein	NNS
cord-001835-0s7ok4uw	5826	15	and	and	CC
cord-001835-0s7ok4uw	5826	16	expose	expose	VB
cord-001835-0s7ok4uw	5826	17	the	the	DT
cord-001835-0s7ok4uw	5826	18	entire	entire	JJ
cord-001835-0s7ok4uw	5826	19	organism	organism	NN
cord-001835-0s7ok4uw	5826	20	,	,	,
cord-001835-0s7ok4uw	5826	21	including	include	VBG
cord-001835-0s7ok4uw	5826	22	CNS	CNS	NNP
cord-001835-0s7ok4uw	5826	23	,	,	,
cord-001835-0s7ok4uw	5826	24	to	to	IN
cord-001835-0s7ok4uw	5826	25	the	the	DT
cord-001835-0s7ok4uw	5826	26	negative	negative	JJ
cord-001835-0s7ok4uw	5826	27	effects	effect	NNS
cord-001835-0s7ok4uw	5826	28	of	of	IN
cord-001835-0s7ok4uw	5826	29	xenobiotics	xenobiotic	NNS
cord-001835-0s7ok4uw	5826	30	,	,	,
cord-001835-0s7ok4uw	5826	31	in	in	IN
cord-001835-0s7ok4uw	5826	32	genetically	genetically	RB
cord-001835-0s7ok4uw	5826	33	predisposed	predisposed	JJ
cord-001835-0s7ok4uw	5826	34	patients	patient	NNS
cord-001835-0s7ok4uw	5826	35	.	.	.
cord-001835-0s7ok4uw	5827	1	In	in	IN
cord-001835-0s7ok4uw	5827	2	this	this	DT
cord-001835-0s7ok4uw	5827	3	study	study	NN
cord-001835-0s7ok4uw	5827	4	some	some	DT
cord-001835-0s7ok4uw	5827	5	possible	possible	JJ
cord-001835-0s7ok4uw	5827	6	protein	protein	NN
cord-001835-0s7ok4uw	5827	7	targets	target	NNS
cord-001835-0s7ok4uw	5827	8	for	for	IN
cord-001835-0s7ok4uw	5827	9	the	the	DT
cord-001835-0s7ok4uw	5827	10	mycotoxinswere	mycotoxinswere	RB
cord-001835-0s7ok4uw	5827	11	identified	identify	VBN
cord-001835-0s7ok4uw	5827	12	to	to	TO
cord-001835-0s7ok4uw	5827	13	evaluate	evaluate	VB
cord-001835-0s7ok4uw	5827	14	if	if	IN
cord-001835-0s7ok4uw	5827	15	the	the	DT
cord-001835-0s7ok4uw	5827	16	bond	bond	NN
cord-001835-0s7ok4uw	5827	17	between	between	IN
cord-001835-0s7ok4uw	5827	18	any	any	DT
cord-001835-0s7ok4uw	5827	19	protein	protein	NN
cord-001835-0s7ok4uw	5827	20	target	target	NN
cord-001835-0s7ok4uw	5827	21	and	and	CC
cord-001835-0s7ok4uw	5827	22	the	the	DT
cord-001835-0s7ok4uw	5827	23	mycotoxin	mycotoxin	NN
cord-001835-0s7ok4uw	5827	24	in	in	IN
cord-001835-0s7ok4uw	5827	25	exam	exam	NN
cord-001835-0s7ok4uw	5827	26	could	could	MD
cord-001835-0s7ok4uw	5827	27	play	play	VB
cord-001835-0s7ok4uw	5827	28	a	a	DT
cord-001835-0s7ok4uw	5827	29	role	role	NN
cord-001835-0s7ok4uw	5827	30	in	in	IN
cord-001835-0s7ok4uw	5827	31	ASD	ASD	NNP
cord-001835-0s7ok4uw	5827	32	.	.	.
cord-001835-0s7ok4uw	5828	1	Twelve	twelve	CD
cord-001835-0s7ok4uw	5828	2	mycotoxins	mycotoxin	NNS
cord-001835-0s7ok4uw	5828	3	were	be	VBD
cord-001835-0s7ok4uw	5828	4	selected	select	VBN
cord-001835-0s7ok4uw	5828	5	(	(	-LRB-
cord-001835-0s7ok4uw	5828	6	ochratoxin	ochratoxin	VB
cord-001835-0s7ok4uw	5828	7	A	A	NNP
cord-001835-0s7ok4uw	5828	8	,	,	,
cord-001835-0s7ok4uw	5828	9	gliotoxin	gliotoxin	NN
cord-001835-0s7ok4uw	5828	10	,	,	,
cord-001835-0s7ok4uw	5828	11	aflatoxin	aflatoxin	NN
cord-001835-0s7ok4uw	5828	12	B1	b1	NN
cord-001835-0s7ok4uw	5828	13	,	,	,
cord-001835-0s7ok4uw	5828	14	aflatoxin	aflatoxin	NN
cord-001835-0s7ok4uw	5828	15	B2	b2	NN
cord-001835-0s7ok4uw	5828	16	,	,	,
cord-001835-0s7ok4uw	5828	17	aflatoxin	aflatoxin	NN
cord-001835-0s7ok4uw	5828	18	M1	M1	NNP
cord-001835-0s7ok4uw	5828	19	,	,	,
cord-001835-0s7ok4uw	5828	20	aflatoxin	aflatoxin	NNP
cord-001835-0s7ok4uw	5828	21	M2	M2	NNP
cord-001835-0s7ok4uw	5828	22	,	,	,
cord-001835-0s7ok4uw	5828	23	aflatoxicol	aflatoxicol	NNP
cord-001835-0s7ok4uw	5828	24	,	,	,
cord-001835-0s7ok4uw	5828	25	a	a	DT
cord-001835-0s7ok4uw	5828	26	-	-	HYPH
cord-001835-0s7ok4uw	5828	27	zearalanol	zearalanol	NN
cord-001835-0s7ok4uw	5828	28	,	,	,
cord-001835-0s7ok4uw	5828	29	b	b	NN
cord-001835-0s7ok4uw	5828	30	-	-	HYPH
cord-001835-0s7ok4uw	5828	31	zeralanol	zeralanol	NNP
cord-001835-0s7ok4uw	5828	32	,	,	,
cord-001835-0s7ok4uw	5828	33	zearalenone	zearalenone	NNP
cord-001835-0s7ok4uw	5828	34	,	,	,
cord-001835-0s7ok4uw	5828	35	deoxynivalenol	deoxynivalenol	NNP
cord-001835-0s7ok4uw	5828	36	,	,	,
cord-001835-0s7ok4uw	5828	37	patulin),which	patulin),which	NNP
cord-001835-0s7ok4uw	5828	38	are	be	VBP
cord-001835-0s7ok4uw	5828	39	contaminants	contaminant	NNS
cord-001835-0s7ok4uw	5828	40	of	of	IN
cord-001835-0s7ok4uw	5828	41	milk	milk	NN
cord-001835-0s7ok4uw	5828	42	and	and	CC
cord-001835-0s7ok4uw	5828	43	cereals	cereal	NNS
cord-001835-0s7ok4uw	5828	44	.	.	.
cord-001835-0s7ok4uw	5829	1	For	for	IN
cord-001835-0s7ok4uw	5829	2	each	each	DT
cord-001835-0s7ok4uw	5829	3	of	of	IN
cord-001835-0s7ok4uw	5829	4	these	these	DT
cord-001835-0s7ok4uw	5829	5	molecules	molecule	NNS
cord-001835-0s7ok4uw	5829	6	,	,	,
cord-001835-0s7ok4uw	5829	7	possible	possible	JJ
cord-001835-0s7ok4uw	5829	8	protein	protein	NN
cord-001835-0s7ok4uw	5829	9	targets	target	NNS
cord-001835-0s7ok4uw	5829	10	were	be	VBD
cord-001835-0s7ok4uw	5829	11	searched	search	VBN
cord-001835-0s7ok4uw	5829	12	by	by	IN
cord-001835-0s7ok4uw	5829	13	a	a	DT
cord-001835-0s7ok4uw	5829	14	reverse	reverse	JJ
cord-001835-0s7ok4uw	5829	15	docking	docking	NN
cord-001835-0s7ok4uw	5829	16	approach	approach	NN
cord-001835-0s7ok4uw	5829	17	using	use	VBG
cord-001835-0s7ok4uw	5829	18	the	the	DT
cord-001835-0s7ok4uw	5829	19	idTargetserver[2].From	idTargetserver[2].From	NNP
cord-001835-0s7ok4uw	5829	20	the	the	DT
cord-001835-0s7ok4uw	5829	21	results	result	NNS
cord-001835-0s7ok4uw	5829	22	given	give	VBN
cord-001835-0s7ok4uw	5829	23	by	by	IN
cord-001835-0s7ok4uw	5829	24	idTarget	idTarget	NNP
cord-001835-0s7ok4uw	5829	25	,	,	,
cord-001835-0s7ok4uw	5829	26	human	human	JJ
cord-001835-0s7ok4uw	5829	27	protein	protein	NN
cord-001835-0s7ok4uw	5829	28	targets	target	NNS
cord-001835-0s7ok4uw	5829	29	expressed	express	VBN
cord-001835-0s7ok4uw	5829	30	in	in	IN
cord-001835-0s7ok4uw	5829	31	the	the	DT
cord-001835-0s7ok4uw	5829	32	brain	brain	NN
cord-001835-0s7ok4uw	5829	33	or	or	CC
cord-001835-0s7ok4uw	5829	34	involved	involve	VBN
cord-001835-0s7ok4uw	5829	35	in	in	IN
cord-001835-0s7ok4uw	5829	36	brain	brain	NN
cord-001835-0s7ok4uw	5829	37	diseaseswere	diseaseswere	NN
cord-001835-0s7ok4uw	5829	38	selected	select	VBN
cord-001835-0s7ok4uw	5829	39	.	.	.
cord-001835-0s7ok4uw	5830	1	Subsequently	subsequently	RB
cord-001835-0s7ok4uw	5830	2	,	,	,
cord-001835-0s7ok4uw	5830	3	a	a	DT
cord-001835-0s7ok4uw	5830	4	direct	direct	JJ
cord-001835-0s7ok4uw	5830	5	docking	docking	NN
cord-001835-0s7ok4uw	5830	6	was	be	VBD
cord-001835-0s7ok4uw	5830	7	made	make	VBN
cord-001835-0s7ok4uw	5830	8	using	use	VBG
cord-001835-0s7ok4uw	5830	9	Auto	Auto	NNP
cord-001835-0s7ok4uw	5830	10	-	-	HYPH
cord-001835-0s7ok4uw	5830	11	Dock	dock	NN
cord-001835-0s7ok4uw	5830	12	4.2	4.2	CD
cord-001835-0s7ok4uw	5830	13	[	[	-LRB-
cord-001835-0s7ok4uw	5830	14	3	3	CD
cord-001835-0s7ok4uw	5830	15	]	]	-RRB-
cord-001835-0s7ok4uw	5830	16	,	,	,
cord-001835-0s7ok4uw	5830	17	in	in	IN
cord-001835-0s7ok4uw	5830	18	orderto	orderto	NN
cord-001835-0s7ok4uw	5830	19	verify	verify	VBP
cord-001835-0s7ok4uw	5830	20	the	the	DT
cord-001835-0s7ok4uw	5830	21	strength	strength	NN
cord-001835-0s7ok4uw	5830	22	of	of	IN
cord-001835-0s7ok4uw	5830	23	the	the	DT
cord-001835-0s7ok4uw	5830	24	interaction	interaction	NN
cord-001835-0s7ok4uw	5830	25	between	between	IN
cord-001835-0s7ok4uw	5830	26	selected	select	VBN
cord-001835-0s7ok4uw	5830	27	proteins	protein	NNS
cord-001835-0s7ok4uw	5830	28	and	and	CC
cord-001835-0s7ok4uw	5830	29	each	each	DT
cord-001835-0s7ok4uw	5830	30	mycotoxin	mycotoxin	NN
cord-001835-0s7ok4uw	5830	31	,	,	,
cord-001835-0s7ok4uw	5830	32	and	and	CC
cord-001835-0s7ok4uw	5830	33	to	to	TO
cord-001835-0s7ok4uw	5830	34	identify	identify	VB
cord-001835-0s7ok4uw	5830	35	the	the	DT
cord-001835-0s7ok4uw	5830	36	mycotoxins	mycotoxin	NNS
cord-001835-0s7ok4uw	5830	37	'	'	POS
cord-001835-0s7ok4uw	5830	38	binding	binding	NN
cord-001835-0s7ok4uw	5830	39	site	site	NN
cord-001835-0s7ok4uw	5830	40	on	on	IN
cord-001835-0s7ok4uw	5830	41	each	each	DT
cord-001835-0s7ok4uw	5830	42	of	of	IN
cord-001835-0s7ok4uw	5830	43	the	the	DT
cord-001835-0s7ok4uw	5830	44	selected	select	VBN
cord-001835-0s7ok4uw	5830	45	protein	protein	NN
cord-001835-0s7ok4uw	5830	46	.	.	.
cord-001835-0s7ok4uw	5831	1	Finally	finally	RB
cord-001835-0s7ok4uw	5831	2	,	,	,
cord-001835-0s7ok4uw	5831	3	the	the	DT
cord-001835-0s7ok4uw	5831	4	bond	bond	NN
cord-001835-0s7ok4uw	5831	5	of	of	IN
cord-001835-0s7ok4uw	5831	6	some	some	DT
cord-001835-0s7ok4uw	5831	7	mycotoxins	mycotoxin	NNS
cord-001835-0s7ok4uw	5831	8	to	to	IN
cord-001835-0s7ok4uw	5831	9	selected	select	VBN
cord-001835-0s7ok4uw	5831	10	protein	protein	NN
cord-001835-0s7ok4uw	5831	11	targets	target	NNS
cord-001835-0s7ok4uw	5831	12	has	have	VBZ
cord-001835-0s7ok4uw	5831	13	been	be	VBN
cord-001835-0s7ok4uw	5831	14	experimentally	experimentally	RB
cord-001835-0s7ok4uw	5831	15	tested	test	VBN
cord-001835-0s7ok4uw	5831	16	.	.	.
cord-001835-0s7ok4uw	5832	1	For	for	IN
cord-001835-0s7ok4uw	5832	2	each	each	DT
cord-001835-0s7ok4uw	5832	3	mycotoxin	mycotoxin	NN
cord-001835-0s7ok4uw	5832	4	,	,	,
cord-001835-0s7ok4uw	5832	5	idTarget	idTarget	NNP
cord-001835-0s7ok4uw	5832	6	returned	return	VBD
cord-001835-0s7ok4uw	5832	7	thousands	thousand	NNS
cord-001835-0s7ok4uw	5832	8	of	of	IN
cord-001835-0s7ok4uw	5832	9	possible	possible	JJ
cord-001835-0s7ok4uw	5832	10	protein	protein	NN
cord-001835-0s7ok4uw	5832	11	targets	target	NNS
cord-001835-0s7ok4uw	5832	12	,	,	,
cord-001835-0s7ok4uw	5832	13	and	and	CC
cord-001835-0s7ok4uw	5832	14	only	only	RB
cord-001835-0s7ok4uw	5832	15	those	those	DT
cord-001835-0s7ok4uw	5832	16	with	with	IN
cord-001835-0s7ok4uw	5832	17	the	the	DT
cord-001835-0s7ok4uw	5832	18	best	good	JJS
cord-001835-0s7ok4uw	5832	19	binding	binding	JJ
cord-001835-0s7ok4uw	5832	20	energy	energy	NN
cord-001835-0s7ok4uw	5832	21	were	be	VBD
cord-001835-0s7ok4uw	5832	22	selected	select	VBN
cord-001835-0s7ok4uw	5832	23	and	and	CC
cord-001835-0s7ok4uw	5832	24	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	5832	25	.	.	.
cord-001835-0s7ok4uw	5833	1	Among	among	IN
cord-001835-0s7ok4uw	5833	2	them	-PRON-	PRP
cord-001835-0s7ok4uw	5833	3	,	,	,
cord-001835-0s7ok4uw	5833	4	human	human	JJ
cord-001835-0s7ok4uw	5833	5	protein	protein	NN
cord-001835-0s7ok4uw	5833	6	targets	target	NNS
cord-001835-0s7ok4uw	5833	7	that	that	WDT
cord-001835-0s7ok4uw	5833	8	are	be	VBP
cord-001835-0s7ok4uw	5833	9	expressed	express	VBN
cord-001835-0s7ok4uw	5833	10	in	in	IN
cord-001835-0s7ok4uw	5833	11	the	the	DT
cord-001835-0s7ok4uw	5833	12	brain	brain	NN
cord-001835-0s7ok4uw	5833	13	or	or	CC
cord-001835-0s7ok4uw	5833	14	that	that	WDT
cord-001835-0s7ok4uw	5833	15	are	be	VBP
cord-001835-0s7ok4uw	5833	16	involved	involve	VBN
cord-001835-0s7ok4uw	5833	17	in	in	IN
cord-001835-0s7ok4uw	5833	18	cerebral	cerebral	JJ
cord-001835-0s7ok4uw	5833	19	diseases	disease	NNS
cord-001835-0s7ok4uw	5833	20	,	,	,
cord-001835-0s7ok4uw	5833	21	have	have	VBP
cord-001835-0s7ok4uw	5833	22	been	be	VBN
cord-001835-0s7ok4uw	5833	23	selected	select	VBN
cord-001835-0s7ok4uw	5833	24	;	;	:
cord-001835-0s7ok4uw	5833	25	moreover	moreover	RB
cord-001835-0s7ok4uw	5833	26	the	the	DT
cord-001835-0s7ok4uw	5833	27	protein	protein	NN
cord-001835-0s7ok4uw	5833	28	targets	target	NNS
cord-001835-0s7ok4uw	5833	29	that	that	WDT
cord-001835-0s7ok4uw	5833	30	were	be	VBD
cord-001835-0s7ok4uw	5833	31	not	not	RB
cord-001835-0s7ok4uw	5833	32	human	human	JJ
cord-001835-0s7ok4uw	5834	1	but	but	CC
cord-001835-0s7ok4uw	5834	2	that	that	DT
cord-001835-0s7ok4uw	5834	3	idTargetselected	idtargetselecte	VBN
cord-001835-0s7ok4uw	5834	4	for	for	IN
cord-001835-0s7ok4uw	5834	5	five	five	CD
cord-001835-0s7ok4uw	5834	6	or	or	CC
cord-001835-0s7ok4uw	5834	7	more	more	JJR
cord-001835-0s7ok4uw	5834	8	mycotoxins	mycotoxin	NNS
cord-001835-0s7ok4uw	5834	9	,	,	,
cord-001835-0s7ok4uw	5834	10	were	be	VBD
cord-001835-0s7ok4uw	5834	11	replaced	replace	VBN
cord-001835-0s7ok4uw	5834	12	with	with	IN
cord-001835-0s7ok4uw	5834	13	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5834	14	human	human	JJ
cord-001835-0s7ok4uw	5834	15	counterparts	counterpart	NNS
cord-001835-0s7ok4uw	5834	16	.	.	.
cord-001835-0s7ok4uw	5835	1	At	at	IN
cord-001835-0s7ok4uw	5835	2	the	the	DT
cord-001835-0s7ok4uw	5835	3	end	end	NN
cord-001835-0s7ok4uw	5835	4	of	of	IN
cord-001835-0s7ok4uw	5835	5	the	the	DT
cord-001835-0s7ok4uw	5835	6	procedure	procedure	NN
cord-001835-0s7ok4uw	5835	7	,	,	,
cord-001835-0s7ok4uw	5835	8	nineteen	nineteen	CD
cord-001835-0s7ok4uw	5835	9	protein	protein	NN
cord-001835-0s7ok4uw	5835	10	targets	target	NNS
cord-001835-0s7ok4uw	5835	11	have	have	VBP
cord-001835-0s7ok4uw	5835	12	been	be	VBN
cord-001835-0s7ok4uw	5835	13	identified	identify	VBN
cord-001835-0s7ok4uw	5835	14	for	for	IN
cord-001835-0s7ok4uw	5835	15	the	the	DT
cord-001835-0s7ok4uw	5835	16	following	follow	VBG
cord-001835-0s7ok4uw	5835	17	direct	direct	JJ
cord-001835-0s7ok4uw	5835	18	docking	docking	NN
cord-001835-0s7ok4uw	5835	19	approach	approach	NN
cord-001835-0s7ok4uw	5835	20	.	.	.
cord-001835-0s7ok4uw	5836	1	From	from	IN
cord-001835-0s7ok4uw	5836	2	the	the	DT
cord-001835-0s7ok4uw	5836	3	docking	docking	NN
cord-001835-0s7ok4uw	5836	4	results	result	NNS
cord-001835-0s7ok4uw	5836	5	,	,	,
cord-001835-0s7ok4uw	5836	6	eight	eight	CD
cord-001835-0s7ok4uw	5836	7	proteins	protein	NNS
cord-001835-0s7ok4uw	5836	8	have	have	VBP
cord-001835-0s7ok4uw	5836	9	been	be	VBN
cord-001835-0s7ok4uw	5836	10	selected	select	VBN
cord-001835-0s7ok4uw	5836	11	for	for	IN
cord-001835-0s7ok4uw	5836	12	experimental	experimental	JJ
cord-001835-0s7ok4uw	5836	13	tests	test	NNS
cord-001835-0s7ok4uw	5836	14	,	,	,
cord-001835-0s7ok4uw	5836	15	having	have	VBG
cord-001835-0s7ok4uw	5836	16	a	a	DT
cord-001835-0s7ok4uw	5836	17	predicted	predict	VBN
cord-001835-0s7ok4uw	5836	18	binding	bind	VBG
cord-001835-0s7ok4uw	5836	19	energy	energy	NN
cord-001835-0s7ok4uw	5836	20	lower	low	JJR
cord-001835-0s7ok4uw	5836	21	than	than	IN
cord-001835-0s7ok4uw	5836	22	27	27	CD
cord-001835-0s7ok4uw	5836	23	kcal	kcal	NNS
cord-001835-0s7ok4uw	5836	24	/	/	SYM
cord-001835-0s7ok4uw	5836	25	mol	mol	NN
cord-001835-0s7ok4uw	5836	26	.	.	.
cord-001835-0s7ok4uw	5837	1	Finally	finally	RB
cord-001835-0s7ok4uw	5837	2	,	,	,
cord-001835-0s7ok4uw	5837	3	the	the	DT
cord-001835-0s7ok4uw	5837	4	interactions	interaction	NNS
cord-001835-0s7ok4uw	5837	5	between	between	IN
cord-001835-0s7ok4uw	5837	6	Acetylcholinesterase	acetylcholinesterase	NN
cord-001835-0s7ok4uw	5837	7	(	(	-LRB-
cord-001835-0s7ok4uw	5837	8	AChE	ache	NN
cord-001835-0s7ok4uw	5837	9	)	)	-RRB-
cord-001835-0s7ok4uw	5837	10	,	,	,
cord-001835-0s7ok4uw	5837	11	b	b	NN
cord-001835-0s7ok4uw	5837	12	-	-	HYPH
cord-001835-0s7ok4uw	5837	13	secretase	secretase	NNP
cord-001835-0s7ok4uw	5837	14	(	(	-LRB-
cord-001835-0s7ok4uw	5837	15	BACE1	BACE1	NNP
cord-001835-0s7ok4uw	5837	16	)	)	-RRB-
cord-001835-0s7ok4uw	5837	17	and	and	CC
cord-001835-0s7ok4uw	5837	18	Neuroligin-4	Neuroligin-4	NNP
cord-001835-0s7ok4uw	5837	19	,	,	,
cord-001835-0s7ok4uw	5837	20	X	x	NN
cord-001835-0s7ok4uw	5837	21	-	-	HYPH
cord-001835-0s7ok4uw	5837	22	linked	link	VBN
cord-001835-0s7ok4uw	5837	23	(	(	-LRB-
cord-001835-0s7ok4uw	5837	24	NLG4X	NLG4X	NNP
cord-001835-0s7ok4uw	5837	25	)	)	-RRB-
cord-001835-0s7ok4uw	5837	26	with	with	IN
cord-001835-0s7ok4uw	5837	27	Aflatoxin	aflatoxin	NN
cord-001835-0s7ok4uw	5837	28	B1	b1	NN
cord-001835-0s7ok4uw	5837	29	,	,	,
cord-001835-0s7ok4uw	5837	30	Aflatoxin	Aflatoxin	NNP
cord-001835-0s7ok4uw	5837	31	B2	b2	NN
cord-001835-0s7ok4uw	5837	32	,	,	,
cord-001835-0s7ok4uw	5837	33	Gliotoxin	Gliotoxin	NNP
cord-001835-0s7ok4uw	5837	34	,	,	,
cord-001835-0s7ok4uw	5837	35	Ochratoxin	Ochratoxin	NNP
cord-001835-0s7ok4uw	5837	36	A	A	NNP
cord-001835-0s7ok4uw	5837	37	and	and	CC
cord-001835-0s7ok4uw	5837	38	Deoxynivalenol	Deoxynivalenol	NNP
cord-001835-0s7ok4uw	5837	39	,	,	,
cord-001835-0s7ok4uw	5837	40	were	be	VBD
cord-001835-0s7ok4uw	5837	41	evaluatedusing	evaluateduse	VBG
cord-001835-0s7ok4uw	5837	42	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	5837	43	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	5837	44	and	and	CC
cord-001835-0s7ok4uw	5837	45	microscale	microscale	JJ
cord-001835-0s7ok4uw	5837	46	thermophoresis	thermophoresis	NN
cord-001835-0s7ok4uw	5837	47	.	.	.
cord-001835-0s7ok4uw	5838	1	These	these	DT
cord-001835-0s7ok4uw	5838	2	experiments	experiment	NNS
cord-001835-0s7ok4uw	5838	3	confirmed	confirm	VBD
cord-001835-0s7ok4uw	5838	4	the	the	DT
cord-001835-0s7ok4uw	5838	5	presence	presence	NN
cord-001835-0s7ok4uw	5838	6	of	of	IN
cord-001835-0s7ok4uw	5838	7	an	an	DT
cord-001835-0s7ok4uw	5838	8	interaction	interaction	NN
cord-001835-0s7ok4uw	5838	9	between	between	IN
cord-001835-0s7ok4uw	5838	10	BACE1	BACE1	NNP
cord-001835-0s7ok4uw	5838	11	and	and	CC
cord-001835-0s7ok4uw	5838	12	Aflatoxin	aflatoxin	NN
cord-001835-0s7ok4uw	5838	13	B1	b1	NN
cord-001835-0s7ok4uw	5838	14	idTarget	idTarget	NNP
cord-001835-0s7ok4uw	5838	15	:	:	:
cord-001835-0s7ok4uw	5838	16	a	a	DT
cord-001835-0s7ok4uw	5838	17	web	web	NN
cord-001835-0s7ok4uw	5838	18	server	server	NN
cord-001835-0s7ok4uw	5838	19	for	for	IN
cord-001835-0s7ok4uw	5838	20	identifying	identify	VBG
cord-001835-0s7ok4uw	5838	21	protein	protein	NN
cord-001835-0s7ok4uw	5838	22	targets	target	NNS
cord-001835-0s7ok4uw	5838	23	of	of	IN
cord-001835-0s7ok4uw	5838	24	small	small	JJ
cord-001835-0s7ok4uw	5838	25	chemical	chemical	NN
cord-001835-0s7ok4uw	5838	26	molecules	molecule	NNS
cord-001835-0s7ok4uw	5838	27	with	with	IN
cord-001835-0s7ok4uw	5838	28	robust	robust	JJ
cord-001835-0s7ok4uw	5838	29	scoring	scoring	NN
cord-001835-0s7ok4uw	5838	30	functions	function	NNS
cord-001835-0s7ok4uw	5838	31	and	and	CC
cord-001835-0s7ok4uw	5838	32	a	a	DT
cord-001835-0s7ok4uw	5838	33	divide	divide	VB
cord-001835-0s7ok4uw	5838	34	-	-	HYPH
cord-001835-0s7ok4uw	5838	35	and	and	CC
cord-001835-0s7ok4uw	5838	36	-	-	HYPH
cord-001835-0s7ok4uw	5838	37	conquer	conquer	NN
cord-001835-0s7ok4uw	5838	38	docking	docking	NN
cord-001835-0s7ok4uw	5838	39	approach	approach	NN
cord-001835-0s7ok4uw	5838	40	the	the	DT
cord-001835-0s7ok4uw	5838	41	calculation	calculation	NN
cord-001835-0s7ok4uw	5838	42	of	of	IN
cord-001835-0s7ok4uw	5838	43	spatial	spatial	JJ
cord-001835-0s7ok4uw	5838	44	structure	structure	NN
cord-001835-0s7ok4uw	5838	45	and	and	CC
cord-001835-0s7ok4uw	5838	46	"	"	``
cord-001835-0s7ok4uw	5838	47	assembling	assemble	VBG
cord-001835-0s7ok4uw	5838	48	"	"	''
cord-001835-0s7ok4uw	5838	49	of	of	IN
cord-001835-0s7ok4uw	5838	50	the	the	DT
cord-001835-0s7ok4uw	5838	51	whole	whole	JJ
cord-001835-0s7ok4uw	5838	52	protein	protein	NN
cord-001835-0s7ok4uw	5838	53	from	from	IN
cord-001835-0s7ok4uw	5838	54	the	the	DT
cord-001835-0s7ok4uw	5838	55	obtained	obtain	VBN
cord-001835-0s7ok4uw	5838	56	peptide	peptide	JJ
cord-001835-0s7ok4uw	5838	57	structures	structure	NNS
cord-001835-0s7ok4uw	5838	58	were	be	VBD
cord-001835-0s7ok4uw	5838	59	performed	perform	VBN
cord-001835-0s7ok4uw	5838	60	by	by	IN
cord-001835-0s7ok4uw	5838	61	using	use	VBG
cord-001835-0s7ok4uw	5838	62	molecular	molecular	JJ
cord-001835-0s7ok4uw	5838	63	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	5838	64	of	of	IN
cord-001835-0s7ok4uw	5838	65	the	the	DT
cord-001835-0s7ok4uw	5838	66	protein	protein	NN
cord-001835-0s7ok4uw	5838	67	in	in	IN
cord-001835-0s7ok4uw	5838	68	the	the	DT
cord-001835-0s7ok4uw	5838	69	fully	fully	RB
cord-001835-0s7ok4uw	5838	70	hydrated	hydrated	JJ
cord-001835-0s7ok4uw	5838	71	1-palmitoyl-2-oleoyl	1-palmitoyl-2-oleoyl	CD
cord-001835-0s7ok4uw	5838	72	-	-	HYPH
cord-001835-0s7ok4uw	5838	73	sn	sn	NN
cord-001835-0s7ok4uw	5838	74	-	-	HYPH
cord-001835-0s7ok4uw	5838	75	glycero-3-phosphatidylcholine	glycero-3-phosphatidylcholine	JJ
cord-001835-0s7ok4uw	5838	76	(	(	-LRB-
cord-001835-0s7ok4uw	5838	77	POPC	POPC	NNP
cord-001835-0s7ok4uw	5838	78	)	)	-RRB-
cord-001835-0s7ok4uw	5838	79	[	[	-LRB-
cord-001835-0s7ok4uw	5838	80	4	4	CD
cord-001835-0s7ok4uw	5838	81	]	]	-RRB-
cord-001835-0s7ok4uw	5838	82	.	.	.
cord-001835-0s7ok4uw	5839	1	The	the	DT
cord-001835-0s7ok4uw	5839	2	obtained	obtain	VBN
cord-001835-0s7ok4uw	5839	3	structural	structural	JJ
cord-001835-0s7ok4uw	5839	4	model	model	NN
cord-001835-0s7ok4uw	5839	5	may	may	MD
cord-001835-0s7ok4uw	5839	6	contribute	contribute	VB
cord-001835-0s7ok4uw	5839	7	to	to	IN
cord-001835-0s7ok4uw	5839	8	identification	identification	NN
cord-001835-0s7ok4uw	5839	9	of	of	IN
cord-001835-0s7ok4uw	5839	10	UL49.5	ul49.5	JJ
cord-001835-0s7ok4uw	5839	11	active	active	JJ
cord-001835-0s7ok4uw	5839	12	sites	site	NNS
cord-001835-0s7ok4uw	5839	13	and	and	CC
cord-001835-0s7ok4uw	5839	14	elucidation	elucidation	NN
cord-001835-0s7ok4uw	5839	15	of	of	IN
cord-001835-0s7ok4uw	5839	16	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5839	17	mode	mode	NN
cord-001835-0s7ok4uw	5839	18	of	of	IN
cord-001835-0s7ok4uw	5839	19	action	action	NN
cord-001835-0s7ok4uw	5839	20	NMR	NMR	NNP
cord-001835-0s7ok4uw	5839	21	structural	structural	JJ
cord-001835-0s7ok4uw	5839	22	studies	study	NNS
cord-001835-0s7ok4uw	5839	23	of	of	IN
cord-001835-0s7ok4uw	5839	24	membrane	membrane	NN
cord-001835-0s7ok4uw	5839	25	proteins	protein	NNS
cord-001835-0s7ok4uw	5839	26	Acknowledgments	acknowledgment	NNS
cord-001835-0s7ok4uw	5839	27	:	:	:
cord-001835-0s7ok4uw	5839	28	Polish	Polish	NNP
cord-001835-0s7ok4uw	5839	29	National	National	NNP
cord-001835-0s7ok4uw	5839	30	Centre	Centre	NNP
cord-001835-0s7ok4uw	5839	31	for	for	IN
cord-001835-0s7ok4uw	5839	32	Research	Research	NNP
cord-001835-0s7ok4uw	5839	33	and	and	CC
cord-001835-0s7ok4uw	5839	34	Development	Development	NNP
cord-001835-0s7ok4uw	5839	35	-grant	-grant	JJ
cord-001835-0s7ok4uw	5839	36	number	number	NN
cord-001835-0s7ok4uw	5839	37	178479	178479	CD
cord-001835-0s7ok4uw	5840	1	PL-017	PL-017	NNP
cord-001835-0s7ok4uw	5840	2	Functional	functional	JJ
cord-001835-0s7ok4uw	5840	3	and	and	CC
cord-001835-0s7ok4uw	5840	4	mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	5840	5	studies	study	NNS
cord-001835-0s7ok4uw	5840	6	of	of	IN
cord-001835-0s7ok4uw	5840	7	dysferlin	dysferlin	NNP
cord-001835-0s7ok4uw	5840	8	,	,	,
cord-001835-0s7ok4uw	5840	9	an	an	DT
cord-001835-0s7ok4uw	5840	10	essential	essential	JJ
cord-001835-0s7ok4uw	5840	11	protein	protein	NN
cord-001835-0s7ok4uw	5840	12	in	in	IN
cord-001835-0s7ok4uw	5840	13	cell	cell	NN
cord-001835-0s7ok4uw	5840	14	membrane	membrane	NN
cord-001835-0s7ok4uw	5840	15	repair	repair	NN
cord-001835-0s7ok4uw	5840	16	References	reference	NNS
cord-001835-0s7ok4uw	5841	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	5841	2	the	the	DT
cord-001835-0s7ok4uw	5841	3	'	'	``
cord-001835-0s7ok4uw	5841	4	m	m	NN
cord-001835-0s7ok4uw	5841	5	'	'	''
cord-001835-0s7ok4uw	5841	6	parameter	parameter	NN
cord-001835-0s7ok4uw	5841	7	,	,	,
cord-001835-0s7ok4uw	5841	8	which	which	WDT
cord-001835-0s7ok4uw	5841	9	represents	represent	VBZ
cord-001835-0s7ok4uw	5841	10	the	the	DT
cord-001835-0s7ok4uw	5841	11	denaturant	denaturant	JJ
cord-001835-0s7ok4uw	5841	12	effect	effect	NN
cord-001835-0s7ok4uw	5841	13	on	on	IN
cord-001835-0s7ok4uw	5841	14	the	the	DT
cord-001835-0s7ok4uw	5841	15	protein	protein	NN
cord-001835-0s7ok4uw	5841	16	stability	stability	NN
cord-001835-0s7ok4uw	5841	17	,	,	,
cord-001835-0s7ok4uw	5841	18	is	be	VBZ
cord-001835-0s7ok4uw	5841	19	669	669	CD
cord-001835-0s7ok4uw	5841	20	cal•mol-1	cal•mol-1	NNP
cord-001835-0s7ok4uw	5841	21	for	for	IN
cord-001835-0s7ok4uw	5841	22	bglA	bgla	NN
cord-001835-0s7ok4uw	5841	23	and	and	CC
cord-001835-0s7ok4uw	5841	24	860	860	CD
cord-001835-0s7ok4uw	5841	25	cal•mol-1	cal•mol-1	NNS
cord-001835-0s7ok4uw	5841	26	for	for	IN
cord-001835-0s7ok4uw	5841	27	bglB	bglb	CD
cord-001835-0s7ok4uw	5842	1	Albert	Albert	NNP
cord-001835-0s7ok4uw	5842	2	Einstein	Einstein	NNP
cord-001835-0s7ok4uw	5842	3	College	College	NNP
cord-001835-0s7ok4uw	5842	4	of	of	IN
cord-001835-0s7ok4uw	5842	5	Medicine	Medicine	NNP
cord-001835-0s7ok4uw	5842	6	Protein	Protein	NNP
cord-001835-0s7ok4uw	5842	7	structure	structure	NN
cord-001835-0s7ok4uw	5842	8	modeling	modeling	NN
cord-001835-0s7ok4uw	5842	9	,	,	,
cord-001835-0s7ok4uw	5842	10	protein	protein	NN
cord-001835-0s7ok4uw	5842	11	-	-	HYPH
cord-001835-0s7ok4uw	5842	12	protein	protein	NN
cord-001835-0s7ok4uw	5842	13	interaction	interaction	NN
cord-001835-0s7ok4uw	5842	14	Computational	computational	JJ
cord-001835-0s7ok4uw	5842	15	modeling	modeling	NN
cord-001835-0s7ok4uw	5842	16	of	of	IN
cord-001835-0s7ok4uw	5842	17	INI1/	INI1/	NNS
cord-001835-0s7ok4uw	5843	1	SMARCB1	smarcb1	JJ
cord-001835-0s7ok4uw	5843	2	and	and	CC
cord-001835-0s7ok4uw	5843	3	novel	novel	JJ
cord-001835-0s7ok4uw	5843	4	insights	insight	NNS
cord-001835-0s7ok4uw	5843	5	into	into	IN
cord-001835-0s7ok4uw	5843	6	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5843	7	interaction	interaction	NN
cord-001835-0s7ok4uw	5843	8	with	with	IN
cord-001835-0s7ok4uw	5843	9	HIV-1	HIV-1	NNP
cord-001835-0s7ok4uw	5843	10	Integrase	Integrase	NNP
cord-001835-0s7ok4uw	5843	11	Savita	Savita	NNP
cord-001835-0s7ok4uw	5844	1	Bhutoria1	Bhutoria1	NNP
cord-001835-0s7ok4uw	5845	1	Epsteain	Epsteain	NNP
cord-001835-0s7ok4uw	5845	2	Bar	Bar	NNP
cord-001835-0s7ok4uw	5845	3	Virus	Virus	NNP
cord-001835-0s7ok4uw	5845	4	,	,	,
cord-001835-0s7ok4uw	5845	5	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	5845	6	antigen)1	antigen)1	NN
cord-001835-0s7ok4uw	5845	7	.	.	.
cord-001835-0s7ok4uw	5846	1	INI1	INI1	NNP
cord-001835-0s7ok4uw	5847	1	/SMARCB1	/SMARCB1	:
cord-001835-0s7ok4uw	5847	2	has	have	VBZ
cord-001835-0s7ok4uw	5847	3	no	no	DT
cord-001835-0s7ok4uw	5847	4	known	know	VBN
cord-001835-0s7ok4uw	5847	5	structural	structural	JJ
cord-001835-0s7ok4uw	5847	6	homologues	homologue	NNS
cord-001835-0s7ok4uw	5847	7	,	,	,
cord-001835-0s7ok4uw	5847	8	and	and	CC
cord-001835-0s7ok4uw	5847	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5847	10	amino	amino	NN
cord-001835-0s7ok4uw	5847	11	-	-	HYPH
cord-001835-0s7ok4uw	5847	12	acid	acid	NN
cord-001835-0s7ok4uw	5847	13	sequence	sequence	NN
cord-001835-0s7ok4uw	5847	14	yields	yield	VBZ
cord-001835-0s7ok4uw	5847	15	little	little	JJ
cord-001835-0s7ok4uw	5847	16	insight	insight	NN
cord-001835-0s7ok4uw	5847	17	into	into	IN
cord-001835-0s7ok4uw	5847	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5847	19	function	function	NN
cord-001835-0s7ok4uw	5847	20	.	.	.
cord-001835-0s7ok4uw	5848	1	A	a	DT
cord-001835-0s7ok4uw	5848	2	detailed	detailed	JJ
cord-001835-0s7ok4uw	5848	3	understanding	understanding	NN
cord-001835-0s7ok4uw	5848	4	of	of	IN
cord-001835-0s7ok4uw	5848	5	structure	structure	NN
cord-001835-0s7ok4uw	5848	6	-	-	HYPH
cord-001835-0s7ok4uw	5848	7	function	function	NN
cord-001835-0s7ok4uw	5848	8	relationships	relationship	NNS
cord-001835-0s7ok4uw	5848	9	is	be	VBZ
cord-001835-0s7ok4uw	5848	10	hampered	hamper	VBN
cord-001835-0s7ok4uw	5848	11	by	by	IN
cord-001835-0s7ok4uw	5848	12	the	the	DT
cord-001835-0s7ok4uw	5848	13	lack	lack	NN
cord-001835-0s7ok4uw	5848	14	of	of	IN
cord-001835-0s7ok4uw	5848	15	structural	structural	JJ
cord-001835-0s7ok4uw	5848	16	information	information	NN
cord-001835-0s7ok4uw	5848	17	for	for	IN
cord-001835-0s7ok4uw	5848	18	INI1	INI1	NNP
cord-001835-0s7ok4uw	5848	19	.	.	.
cord-001835-0s7ok4uw	5849	1	Computational	computational	JJ
cord-001835-0s7ok4uw	5849	2	methods	method	NNS
cord-001835-0s7ok4uw	5849	3	that	that	WDT
cord-001835-0s7ok4uw	5849	4	model	model	VBP
cord-001835-0s7ok4uw	5849	5	protein	protein	NN
cord-001835-0s7ok4uw	5849	6	/	/	SYM
cord-001835-0s7ok4uw	5849	7	peptide	peptide	NN
cord-001835-0s7ok4uw	5849	8	structures	structure	NNS
cord-001835-0s7ok4uw	5849	9	with	with	IN
cord-001835-0s7ok4uw	5849	10	sufficient	sufficient	JJ
cord-001835-0s7ok4uw	5849	11	accuracy	accuracy	NN
cord-001835-0s7ok4uw	5849	12	to	to	TO
cord-001835-0s7ok4uw	5849	13	facilitate	facilitate	VB
cord-001835-0s7ok4uw	5849	14	functional	functional	JJ
cord-001835-0s7ok4uw	5849	15	studies	study	NNS
cord-001835-0s7ok4uw	5849	16	have	have	VBP
cord-001835-0s7ok4uw	5849	17	had	have	VBN
cord-001835-0s7ok4uw	5849	18	notable	notable	JJ
cord-001835-0s7ok4uw	5849	19	successes	success	NNS
cord-001835-0s7ok4uw	5849	20	.	.	.
cord-001835-0s7ok4uw	5850	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5850	2	carried	carry	VBD
cord-001835-0s7ok4uw	5850	3	out	out	RP
cord-001835-0s7ok4uw	5850	4	combination	combination	NN
cord-001835-0s7ok4uw	5850	5	of	of	IN
cord-001835-0s7ok4uw	5850	6	sequence	sequence	NN
cord-001835-0s7ok4uw	5850	7	analysis	analysis	NN
cord-001835-0s7ok4uw	5850	8	ab	ab	NNP
cord-001835-0s7ok4uw	5850	9	initio	initio	NNP
cord-001835-0s7ok4uw	5850	10	structure	structure	NN
cord-001835-0s7ok4uw	5850	11	modeling	modeling	NN
cord-001835-0s7ok4uw	5850	12	and	and	CC
cord-001835-0s7ok4uw	5850	13	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	5850	14	studies	study	NNS
cord-001835-0s7ok4uw	5850	15	of	of	IN
cord-001835-0s7ok4uw	5850	16	Integrase	Integrase	NNP
cord-001835-0s7ok4uw	5850	17	Binding	Binding	NNP
cord-001835-0s7ok4uw	5850	18	Domain	Domain	NNP
cord-001835-0s7ok4uw	5850	19	of	of	IN
cord-001835-0s7ok4uw	5850	20	INI1	INI1	NNP
cord-001835-0s7ok4uw	5850	21	and	and	CC
cord-001835-0s7ok4uw	5850	22	found	find	VBD
cord-001835-0s7ok4uw	5850	23	it	-PRON-	PRP
cord-001835-0s7ok4uw	5850	24	to	to	TO
cord-001835-0s7ok4uw	5850	25	be	be	VB
cord-001835-0s7ok4uw	5850	26	similar	similar	JJ
cord-001835-0s7ok4uw	5850	27	to	to	IN
cord-001835-0s7ok4uw	5850	28	that	that	DT
cord-001835-0s7ok4uw	5850	29	of	of	IN
cord-001835-0s7ok4uw	5850	30	Phospholipase	Phospholipase	NNP
cord-001835-0s7ok4uw	5850	31	A2	A2	NNP
cord-001835-0s7ok4uw	5850	32	Activating	Activating	NNP
cord-001835-0s7ok4uw	5850	33	Protein	Protein	NNP
cord-001835-0s7ok4uw	5850	34	,	,	,
cord-001835-0s7ok4uw	5850	35	PLAA	PLAA	NNP
cord-001835-0s7ok4uw	5850	36	.	.	.
cord-001835-0s7ok4uw	5851	1	Structural	structural	JJ
cord-001835-0s7ok4uw	5851	2	similarity	similarity	NN
cord-001835-0s7ok4uw	5851	3	with	with	IN
cord-001835-0s7ok4uw	5851	4	this	this	DT
cord-001835-0s7ok4uw	5851	5	distant	distant	JJ
cord-001835-0s7ok4uw	5851	6	protein	protein	NN
cord-001835-0s7ok4uw	5851	7	suggests	suggest	VBZ
cord-001835-0s7ok4uw	5851	8	divergent	divergent	JJ
cord-001835-0s7ok4uw	5851	9	evolution	evolution	NN
cord-001835-0s7ok4uw	5851	10	of	of	IN
cord-001835-0s7ok4uw	5851	11	the	the	DT
cord-001835-0s7ok4uw	5851	12	two	two	CD
cord-001835-0s7ok4uw	5851	13	proteins	protein	NNS
cord-001835-0s7ok4uw	5851	14	.	.	.
cord-001835-0s7ok4uw	5852	1	The	the	DT
cord-001835-0s7ok4uw	5852	2	modeled	model	VBN
cord-001835-0s7ok4uw	5852	3	structure	structure	NN
cord-001835-0s7ok4uw	5852	4	sheds	shed	VBZ
cord-001835-0s7ok4uw	5852	5	light	light	NN
cord-001835-0s7ok4uw	5852	6	on	on	IN
cord-001835-0s7ok4uw	5852	7	various	various	JJ
cord-001835-0s7ok4uw	5852	8	protein	protein	NN
cord-001835-0s7ok4uw	5852	9	-	-	HYPH
cord-001835-0s7ok4uw	5852	10	protein	protein	NN
cord-001835-0s7ok4uw	5852	11	interactions	interaction	NNS
cord-001835-0s7ok4uw	5852	12	of	of	IN
cord-001835-0s7ok4uw	5852	13	INI1	INI1	NNP
cord-001835-0s7ok4uw	5852	14	.	.	.
cord-001835-0s7ok4uw	5853	1	By	by	IN
cord-001835-0s7ok4uw	5853	2	integrating	integrate	VBG
cord-001835-0s7ok4uw	5853	3	the	the	DT
cord-001835-0s7ok4uw	5853	4	experimental	experimental	JJ
cord-001835-0s7ok4uw	5853	5	studies	study	NNS
cord-001835-0s7ok4uw	5853	6	about	about	IN
cord-001835-0s7ok4uw	5853	7	the	the	DT
cord-001835-0s7ok4uw	5853	8	binding	binding	NN
cord-001835-0s7ok4uw	5853	9	,	,	,
cord-001835-0s7ok4uw	5853	10	we	-PRON-	PRP
cord-001835-0s7ok4uw	5853	11	have	have	VBP
cord-001835-0s7ok4uw	5853	12	shown	show	VBN
cord-001835-0s7ok4uw	5853	13	through	through	IN
cord-001835-0s7ok4uw	5853	14	docking	docking	NN
cord-001835-0s7ok4uw	5853	15	,	,	,
cord-001835-0s7ok4uw	5853	16	how	how	WRB
cord-001835-0s7ok4uw	5853	17	a	a	DT
cord-001835-0s7ok4uw	5853	18	fragment	fragment	NN
cord-001835-0s7ok4uw	5853	19	of	of	IN
cord-001835-0s7ok4uw	5853	20	INI1	INI1	NNP
cord-001835-0s7ok4uw	5853	21	binds	bind	VBZ
cord-001835-0s7ok4uw	5853	22	to	to	IN
cord-001835-0s7ok4uw	5853	23	the	the	DT
cord-001835-0s7ok4uw	5853	24	HIV-1	HIV-1	NNP
cord-001835-0s7ok4uw	5853	25	IN	in	RB
cord-001835-0s7ok4uw	5853	26	.	.	.
cord-001835-0s7ok4uw	5854	1	Molecular	molecular	JJ
cord-001835-0s7ok4uw	5854	2	docking	docking	NN
cord-001835-0s7ok4uw	5854	3	and	and	CC
cord-001835-0s7ok4uw	5854	4	experimental	experimental	JJ
cord-001835-0s7ok4uw	5854	5	studies	study	NNS
cord-001835-0s7ok4uw	5854	6	indicated	indicate	VBD
cord-001835-0s7ok4uw	5854	7	that	that	IN
cord-001835-0s7ok4uw	5854	8	two	two	CD
cord-001835-0s7ok4uw	5854	9	proteins	protein	NNS
cord-001835-0s7ok4uw	5854	10	bind	bind	VBP
cord-001835-0s7ok4uw	5854	11	tightly	tightly	RB
cord-001835-0s7ok4uw	5854	12	through	through	IN
cord-001835-0s7ok4uw	5854	13	charged	charge	VBN
cord-001835-0s7ok4uw	5854	14	/	/	SYM
cord-001835-0s7ok4uw	5854	15	polar	polar	JJ
cord-001835-0s7ok4uw	5854	16	residues	residue	NNS
cord-001835-0s7ok4uw	5854	17	surrounding	surround	VBG
cord-001835-0s7ok4uw	5854	18	a	a	DT
cord-001835-0s7ok4uw	5854	19	hydrophobic	hydrophobic	JJ
cord-001835-0s7ok4uw	5854	20	cleft	cleft	NN
cord-001835-0s7ok4uw	5854	21	.	.	.
cord-001835-0s7ok4uw	5855	1	These	these	DT
cord-001835-0s7ok4uw	5855	2	studies	study	NNS
cord-001835-0s7ok4uw	5855	3	provide	provide	VBP
cord-001835-0s7ok4uw	5855	4	first	first	RB
cord-001835-0s7ok4uw	5855	5	modeled	model	VBN
cord-001835-0s7ok4uw	5855	6	structure	structure	NN
cord-001835-0s7ok4uw	5855	7	of	of	IN
cord-001835-0s7ok4uw	5855	8	INI1	INI1	NNP
cord-001835-0s7ok4uw	5855	9	/	/	SYM
cord-001835-0s7ok4uw	5855	10	SMARCB1	SMARCB1	NNS
cord-001835-0s7ok4uw	5855	11	or	or	CC
cord-001835-0s7ok4uw	5855	12	any	any	DT
cord-001835-0s7ok4uw	5855	13	component	component	NN
cord-001835-0s7ok4uw	5855	14	of	of	IN
cord-001835-0s7ok4uw	5855	15	the	the	DT
cord-001835-0s7ok4uw	5855	16	SWI	SWI	NNP
cord-001835-0s7ok4uw	5855	17	/	/	SYM
cord-001835-0s7ok4uw	5855	18	SNF	SNF	NNP
cord-001835-0s7ok4uw	5855	19	complex	complex	NN
cord-001835-0s7ok4uw	5855	20	,	,	,
cord-001835-0s7ok4uw	5855	21	and	and	CC
cord-001835-0s7ok4uw	5855	22	provide	provide	VB
cord-001835-0s7ok4uw	5855	23	structural	structural	JJ
cord-001835-0s7ok4uw	5855	24	basis	basis	NN
cord-001835-0s7ok4uw	5855	25	for	for	IN
cord-001835-0s7ok4uw	5855	26	IN	in	IN
cord-001835-0s7ok4uw	5855	27	-	-	HYPH
cord-001835-0s7ok4uw	5855	28	INI1	INI1	NNP
cord-001835-0s7ok4uw	5855	29	interactions	interaction	NNS
cord-001835-0s7ok4uw	5855	30	.	.	.
cord-001835-0s7ok4uw	5856	1	This	this	DT
cord-001835-0s7ok4uw	5856	2	molecular	molecular	JJ
cord-001835-0s7ok4uw	5856	3	interpretation	interpretation	NN
cord-001835-0s7ok4uw	5856	4	of	of	IN
cord-001835-0s7ok4uw	5856	5	the	the	DT
cord-001835-0s7ok4uw	5856	6	intermolecular	intermolecular	JJ
cord-001835-0s7ok4uw	5856	7	interactions	interaction	NNS
cord-001835-0s7ok4uw	5856	8	is	be	VBZ
cord-001835-0s7ok4uw	5856	9	expected	expect	VBN
cord-001835-0s7ok4uw	5856	10	to	to	TO
cord-001835-0s7ok4uw	5856	11	facilitate	facilitate	VB
cord-001835-0s7ok4uw	5856	12	design	design	NN
cord-001835-0s7ok4uw	5856	13	of	of	IN
cord-001835-0s7ok4uw	5856	14	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	5856	15	as	as	IN
cord-001835-0s7ok4uw	5856	16	novel	novel	JJ
cord-001835-0s7ok4uw	5856	17	class	class	NN
cord-001835-0s7ok4uw	5856	18	of	of	IN
cord-001835-0s7ok4uw	5856	19	anti	anti	JJ
cord-001835-0s7ok4uw	5856	20	-	-	JJ
cord-001835-0s7ok4uw	5856	21	HIV-1	hiv-1	JJ
cord-001835-0s7ok4uw	5856	22	therapeutic	therapeutic	JJ
cord-001835-0s7ok4uw	5856	23	agents	agent	NNS
cord-001835-0s7ok4uw	5856	24	):	):	XX
cord-001835-0s7ok4uw	5857	1	e60734	e60734	NNP
cord-001835-0s7ok4uw	5857	2	.	.	.
cord-001835-0s7ok4uw	5858	1	with	with	IN
cord-001835-0s7ok4uw	5858	2	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5858	3	catalytic	catalytic	JJ
cord-001835-0s7ok4uw	5858	4	activity	activity	NN
cord-001835-0s7ok4uw	5858	5	towards	towards	IN
cord-001835-0s7ok4uw	5858	6	RNA	RNA	NNP
cord-001835-0s7ok4uw	5858	7	substrates	substrate	NNS
cord-001835-0s7ok4uw	5858	8	,	,	,
cord-001835-0s7ok4uw	5858	9	other	other	JJ
cord-001835-0s7ok4uw	5858	10	biological	biological	JJ
cord-001835-0s7ok4uw	5858	11	properties	property	NNS
cord-001835-0s7ok4uw	5858	12	have	have	VBP
cord-001835-0s7ok4uw	5858	13	been	be	VBN
cord-001835-0s7ok4uw	5858	14	reported	report	VBN
cord-001835-0s7ok4uw	5858	15	and	and	CC
cord-001835-0s7ok4uw	5858	16	evolution	evolution	NN
cord-001835-0s7ok4uw	5858	17	studies	study	NNS
cord-001835-0s7ok4uw	5858	18	suggest	suggest	VBP
cord-001835-0s7ok4uw	5858	19	an	an	DT
cord-001835-0s7ok4uw	5858	20	ancestral	ancestral	JJ
cord-001835-0s7ok4uw	5858	21	host	host	NN
cord-001835-0s7ok4uw	5858	22	-	-	HYPH
cord-001835-0s7ok4uw	5858	23	defence	defence	NN
cord-001835-0s7ok4uw	5858	24	function	function	NN
cord-001835-0s7ok4uw	5858	25	in	in	IN
cord-001835-0s7ok4uw	5858	26	vertebrates	vertebrate	NNS
cord-001835-0s7ok4uw	5858	27	.	.	.
cord-001835-0s7ok4uw	5859	1	Indeed	indeed	RB
cord-001835-0s7ok4uw	5859	2	,	,	,
cord-001835-0s7ok4uw	5859	3	genetic	genetic	JJ
cord-001835-0s7ok4uw	5859	4	studies	study	NNS
cord-001835-0s7ok4uw	5859	5	confirmed	confirm	VBD
cord-001835-0s7ok4uw	5859	6	a	a	DT
cord-001835-0s7ok4uw	5859	7	rapid	rapid	JJ
cord-001835-0s7ok4uw	5859	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	5859	9	evolution	evolution	NN
cord-001835-0s7ok4uw	5859	10	within	within	IN
cord-001835-0s7ok4uw	5859	11	the	the	DT
cord-001835-0s7ok4uw	5859	12	family	family	NN
cord-001835-0s7ok4uw	5859	13	,	,	,
cord-001835-0s7ok4uw	5859	14	a	a	DT
cord-001835-0s7ok4uw	5859	15	distinctive	distinctive	JJ
cord-001835-0s7ok4uw	5859	16	trait	trait	NN
cord-001835-0s7ok4uw	5859	17	for	for	IN
cord-001835-0s7ok4uw	5859	18	host	host	NN
cord-001835-0s7ok4uw	5859	19	defence	defence	NN
cord-001835-0s7ok4uw	5859	20	proteins	protein	NNS
cord-001835-0s7ok4uw	5859	21	exposed	expose	VBN
cord-001835-0s7ok4uw	5859	22	to	to	IN
cord-001835-0s7ok4uw	5859	23	a	a	DT
cord-001835-0s7ok4uw	5859	24	changing	change	VBG
cord-001835-0s7ok4uw	5859	25	pathogen	pathogen	NN
cord-001835-0s7ok4uw	5859	26	environment	environment	NN
cord-001835-0s7ok4uw	5859	27	.	.	.
cord-001835-0s7ok4uw	5860	1	Previous	previous	JJ
cord-001835-0s7ok4uw	5860	2	studies	study	NNS
cord-001835-0s7ok4uw	5860	3	from	from	IN
cord-001835-0s7ok4uw	5860	4	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5860	5	laboratory	laboratory	NN
cord-001835-0s7ok4uw	5860	6	characterized	characterize	VBD
cord-001835-0s7ok4uw	5860	7	the	the	DT
cord-001835-0s7ok4uw	5860	8	wide	wide	JJ
cord-001835-0s7ok4uw	5860	9	spectra	spectra	JJ
cord-001835-0s7ok4uw	5860	10	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5860	11	activity	activity	NN
cord-001835-0s7ok4uw	5860	12	of	of	IN
cord-001835-0s7ok4uw	5860	13	two	two	CD
cord-001835-0s7ok4uw	5860	14	highly	highly	RB
cord-001835-0s7ok4uw	5860	15	cationic	cationic	JJ
cord-001835-0s7ok4uw	5860	16	human	human	JJ
cord-001835-0s7ok4uw	5860	17	RNases	rnase	NNS
cord-001835-0s7ok4uw	5860	18	:	:	:
cord-001835-0s7ok4uw	5860	19	the	the	DT
cord-001835-0s7ok4uw	5860	20	eosinophil	eosinophil	JJ
cord-001835-0s7ok4uw	5860	21	RNase	RNase	NNP
cord-001835-0s7ok4uw	5860	22	3	3	CD
cord-001835-0s7ok4uw	5860	23	and	and	CC
cord-001835-0s7ok4uw	5860	24	the	the	DT
cord-001835-0s7ok4uw	5860	25	skin	skin	NN
cord-001835-0s7ok4uw	5860	26	derived	derive	VBD
cord-001835-0s7ok4uw	5860	27	RNase	RNase	NNP
cord-001835-0s7ok4uw	5860	28	Ribonucleases	Ribonucleases	NNP
cord-001835-0s7ok4uw	5860	29	6	6	CD
cord-001835-0s7ok4uw	5860	30	and	and	CC
cord-001835-0s7ok4uw	5860	31	7	7	CD
cord-001835-0s7ok4uw	5860	32	have	have	VBP
cord-001835-0s7ok4uw	5860	33	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5860	34	function	function	NN
cord-001835-0s7ok4uw	5860	35	in	in	IN
cord-001835-0s7ok4uw	5860	36	the	the	DT
cord-001835-0s7ok4uw	5860	37	human	human	JJ
cord-001835-0s7ok4uw	5860	38	and	and	CC
cord-001835-0s7ok4uw	5860	39	murine	murine	JJ
cord-001835-0s7ok4uw	5860	40	urinary	urinary	JJ
cord-001835-0s7ok4uw	5860	41	tract	tract	NN
cord-001835-0s7ok4uw	5860	42	Structural	structural	JJ
cord-001835-0s7ok4uw	5860	43	determinants	determinant	NNS
cord-001835-0s7ok4uw	5860	44	of	of	IN
cord-001835-0s7ok4uw	5860	45	the	the	DT
cord-001835-0s7ok4uw	5860	46	eosinophil	eosinophil	JJ
cord-001835-0s7ok4uw	5860	47	cationic	cationic	JJ
cord-001835-0s7ok4uw	5860	48	protein	protein	NN
cord-001835-0s7ok4uw	5860	49	antimicrobial	antimicrobial	NN
cord-001835-0s7ok4uw	5860	50	activity	activity	NN
cord-001835-0s7ok4uw	5861	1	Two	two	CD
cord-001835-0s7ok4uw	5861	2	human	human	JJ
cord-001835-0s7ok4uw	5861	3	host	host	NN
cord-001835-0s7ok4uw	5861	4	defense	defense	NN
cord-001835-0s7ok4uw	5861	5	ribonucleases	ribonuclease	NNS
cord-001835-0s7ok4uw	5861	6	against	against	IN
cord-001835-0s7ok4uw	5861	7	mycobacteria	mycobacterium	NNS
cord-001835-0s7ok4uw	5861	8	,	,	,
cord-001835-0s7ok4uw	5861	9	the	the	DT
cord-001835-0s7ok4uw	5861	10	eosinophil	eosinophil	JJ
cord-001835-0s7ok4uw	5861	11	cationic	cationic	JJ
cord-001835-0s7ok4uw	5861	12	protein	protein	NN
cord-001835-0s7ok4uw	5861	13	(	(	-LRB-
cord-001835-0s7ok4uw	5861	14	RNase	RNase	NNP
cord-001835-0s7ok4uw	5861	15	3	3	CD
cord-001835-0s7ok4uw	5861	16	)	)	-RRB-
cord-001835-0s7ok4uw	5861	17	and	and	CC
cord-001835-0s7ok4uw	5861	18	RNase	RNase	NNP
cord-001835-0s7ok4uw	5861	19	7	7	CD
cord-001835-0s7ok4uw	5861	20	the	the	DT
cord-001835-0s7ok4uw	5861	21	regulatory	regulatory	JJ
cord-001835-0s7ok4uw	5861	22	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5861	23	that	that	WDT
cord-001835-0s7ok4uw	5861	24	we	-PRON-	PRP
cord-001835-0s7ok4uw	5861	25	are	be	VBP
cord-001835-0s7ok4uw	5861	26	reporting	report	VBG
cord-001835-0s7ok4uw	5861	27	will	will	MD
cord-001835-0s7ok4uw	5861	28	contribute	contribute	VB
cord-001835-0s7ok4uw	5861	29	to	to	TO
cord-001835-0s7ok4uw	5861	30	prevent	prevent	VB
cord-001835-0s7ok4uw	5861	31	both	both	DT
cord-001835-0s7ok4uw	5861	32	NAD1	NAD1	NNP
cord-001835-0s7ok4uw	5861	33	exhaustion	exhaustion	NN
cord-001835-0s7ok4uw	5861	34	and	and	CC
cord-001835-0s7ok4uw	5861	35	accumulation	accumulation	NN
cord-001835-0s7ok4uw	5861	36	of	of	IN
cord-001835-0s7ok4uw	5861	37	the	the	DT
cord-001835-0s7ok4uw	5861	38	toxic	toxic	JJ
cord-001835-0s7ok4uw	5861	39	BAL	bal	NN
cord-001835-0s7ok4uw	5861	40	.	.	.
cord-001835-0s7ok4uw	5862	1	To	to	IN
cord-001835-0s7ok4uw	5862	2	the	the	DT
cord-001835-0s7ok4uw	5862	3	best	good	JJS
cord-001835-0s7ok4uw	5862	4	of	of	IN
cord-001835-0s7ok4uw	5862	5	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5862	6	knowledge	knowledge	NN
cord-001835-0s7ok4uw	5862	7	,	,	,
cord-001835-0s7ok4uw	5862	8	this	this	DT
cord-001835-0s7ok4uw	5862	9	is	be	VBZ
cord-001835-0s7ok4uw	5862	10	the	the	DT
cord-001835-0s7ok4uw	5862	11	first	first	JJ
cord-001835-0s7ok4uw	5862	12	report	report	NN
cord-001835-0s7ok4uw	5862	13	of	of	IN
cord-001835-0s7ok4uw	5862	14	a	a	DT
cord-001835-0s7ok4uw	5862	15	novel	novel	JJ
cord-001835-0s7ok4uw	5862	16	reversible	reversible	JJ
cord-001835-0s7ok4uw	5862	17	covalent	covalent	JJ
cord-001835-0s7ok4uw	5862	18	modification	modification	NN
cord-001835-0s7ok4uw	5862	19	of	of	IN
cord-001835-0s7ok4uw	5862	20	an	an	DT
cord-001835-0s7ok4uw	5862	21	ALDH	ALDH	NNP
cord-001835-0s7ok4uw	5862	22	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5862	23	involving	involve	VBG
cord-001835-0s7ok4uw	5862	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5862	25	own	own	JJ
cord-001835-0s7ok4uw	5862	26	substrate	substrate	NN
cord-001835-0s7ok4uw	5862	27	Anna	Anna	NNP
cord-001835-0s7ok4uw	5862	28	Lewandrowska	Lewandrowska	NNP
cord-001835-0s7ok4uw	5862	29	1	1	CD
cord-001835-0s7ok4uw	5862	30	,	,	,
cord-001835-0s7ok4uw	5862	31	Aldona	Aldona	NNP
cord-001835-0s7ok4uw	5862	32	Jeli	Jeli	NNP
cord-001835-0s7ok4uw	5862	33	nska	nska	NNP
cord-001835-0s7ok4uw	5862	34	1	1	CD
cord-001835-0s7ok4uw	5862	35	,	,	,
cord-001835-0s7ok4uw	5862	36	Agnieszka	Agnieszka	NNP
cord-001835-0s7ok4uw	5862	37	Wi	Wi	NNP
cord-001835-0s7ok4uw	5862	38	sniewska	sniewska	NN
cord-001835-0s7ok4uw	5862	39	1	1	CD
cord-001835-0s7ok4uw	5862	40	Acknowledgement	acknowledgement	NN
cord-001835-0s7ok4uw	5862	41	:	:	:
cord-001835-0s7ok4uw	5863	1	This	this	DT
cord-001835-0s7ok4uw	5863	2	research	research	NN
cord-001835-0s7ok4uw	5863	3	was	be	VBD
cord-001835-0s7ok4uw	5863	4	supported	support	VBN
cord-001835-0s7ok4uw	5863	5	by	by	IN
cord-001835-0s7ok4uw	5863	6	the	the	DT
cord-001835-0s7ok4uw	5863	7	Inactivation	Inactivation	NNP
cord-001835-0s7ok4uw	5863	8	of	of	IN
cord-001835-0s7ok4uw	5863	9	the	the	DT
cord-001835-0s7ok4uw	5863	10	Fxr	Fxr	NNP
cord-001835-0s7ok4uw	5863	11	gene	gene	NN
cord-001835-0s7ok4uw	5863	12	reduces	reduce	VBZ
cord-001835-0s7ok4uw	5863	13	Aqp2	aqp2	JJ
cord-001835-0s7ok4uw	5863	14	expression	expression	NN
cord-001835-0s7ok4uw	5863	15	and	and	CC
cord-001835-0s7ok4uw	5863	16	impairs	impair	VBZ
cord-001835-0s7ok4uw	5863	17	urine	urine	NN
cord-001835-0s7ok4uw	5863	18	concentrating	concentrate	VBG
cord-001835-0s7ok4uw	5863	19	ability	ability	NN
cord-001835-0s7ok4uw	5863	20	,	,	,
cord-001835-0s7ok4uw	5863	21	which	which	WDT
cord-001835-0s7ok4uw	5863	22	leads	lead	VBZ
cord-001835-0s7ok4uw	5863	23	to	to	IN
cord-001835-0s7ok4uw	5863	24	a	a	DT
cord-001835-0s7ok4uw	5863	25	polyuria	polyuria	NN
cord-001835-0s7ok4uw	5863	26	or	or	CC
cord-001835-0s7ok4uw	5863	27	urine	urine	NN
cord-001835-0s7ok4uw	5863	28	dilution	dilution	NN
cord-001835-0s7ok4uw	5863	29	phenotype	phenotype	NN
cord-001835-0s7ok4uw	5863	30	.	.	.
cord-001835-0s7ok4uw	5864	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5864	2	have	have	VBP
cord-001835-0s7ok4uw	5864	3	previously	previously	RB
cord-001835-0s7ok4uw	5864	4	found	find	VBN
cord-001835-0s7ok4uw	5864	5	that	that	IN
cord-001835-0s7ok4uw	5864	6	Pon1-/-mice	Pon1-/-mice	NNP
cord-001835-0s7ok4uw	5864	7	exhibit	exhibit	VB
cord-001835-0s7ok4uw	5864	8	a	a	DT
cord-001835-0s7ok4uw	5864	9	polyuria	polyuria	NN
cord-001835-0s7ok4uw	5864	10	phenotype	phenotype	NN
cord-001835-0s7ok4uw	5864	11	and	and	CC
cord-001835-0s7ok4uw	5864	12	produce	produce	VB
cord-001835-0s7ok4uw	5864	13	twice	twice	RB
cord-001835-0s7ok4uw	5864	14	as	as	RB
cord-001835-0s7ok4uw	5864	15	much	much	JJ
cord-001835-0s7ok4uw	5864	16	24-h	24-h	JJ
cord-001835-0s7ok4uw	5864	17	urine	urine	NN
cord-001835-0s7ok4uw	5864	18	as	as	IN
cord-001835-0s7ok4uw	5864	19	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5864	20	wild	wild	JJ
cord-001835-0s7ok4uw	5864	21	type	type	NN
cord-001835-0s7ok4uw	5864	22	Pon11/1	Pon11/1	NNP
cord-001835-0s7ok4uw	5864	23	littermates	littermate	NNS
cord-001835-0s7ok4uw	5865	1	(	(	-LRB-
cord-001835-0s7ok4uw	5865	2	Borowczyk	Borowczyk	NNP
cord-001835-0s7ok4uw	5865	3	K	K	NNP
cord-001835-0s7ok4uw	5865	4	et	et	NNP
cord-001835-0s7ok4uw	5865	5	al	al	NNP
cord-001835-0s7ok4uw	5865	6	.	.	.
cord-001835-0s7ok4uw	5866	1	Metabolism	metabolism	NN
cord-001835-0s7ok4uw	5866	2	and	and	CC
cord-001835-0s7ok4uw	5866	3	neurotoxicity	neurotoxicity	NN
cord-001835-0s7ok4uw	5866	4	of	of	IN
cord-001835-0s7ok4uw	5866	5	homocysteine	homocysteine	NN
cord-001835-0s7ok4uw	5866	6	thiolactone	thiolactone	NN
cord-001835-0s7ok4uw	5866	7	in	in	IN
cord-001835-0s7ok4uw	5866	8	mice	mouse	NNS
cord-001835-0s7ok4uw	5866	9	:	:	:
cord-001835-0s7ok4uw	5866	10	evidence	evidence	NN
cord-001835-0s7ok4uw	5866	11	for	for	IN
cord-001835-0s7ok4uw	5866	12	a	a	DT
cord-001835-0s7ok4uw	5866	13	protective	protective	JJ
cord-001835-0s7ok4uw	5866	14	role	role	NN
cord-001835-0s7ok4uw	5866	15	of	of	IN
cord-001835-0s7ok4uw	5866	16	paraoxonase	paraoxonase	NNP
cord-001835-0s7ok4uw	5866	17	1	1	CD
cord-001835-0s7ok4uw	5866	18	Development	Development	NNP
cord-001835-0s7ok4uw	5866	19	and	and	CC
cord-001835-0s7ok4uw	5866	20	application	application	NN
cord-001835-0s7ok4uw	5866	21	of	of	IN
cord-001835-0s7ok4uw	5866	22	novel	novel	JJ
cord-001835-0s7ok4uw	5866	23	non	non	NNP
cord-001835-0s7ok4uw	5866	24	-	-	JJ
cord-001835-0s7ok4uw	5866	25	Ewald	Ewald	NNP
cord-001835-0s7ok4uw	5866	26	methods	method	NNS
cord-001835-0s7ok4uw	5866	27	for	for	IN
cord-001835-0s7ok4uw	5866	28	calculating	calculate	VBG
cord-001835-0s7ok4uw	5866	29	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	5866	30	interactions	interaction	NNS
cord-001835-0s7ok4uw	5866	31	in	in	IN
cord-001835-0s7ok4uw	5866	32	molecular	molecular	JJ
cord-001835-0s7ok4uw	5866	33	simulations	simulation	NNS
cord-001835-0s7ok4uw	5866	34	Ikuo	Ikuo	NNP
cord-001835-0s7ok4uw	5866	35	Fukuda	Fukuda	NNP
cord-001835-0s7ok4uw	5866	36	1	1	CD
cord-001835-0s7ok4uw	5866	37	,	,	,
cord-001835-0s7ok4uw	5866	38	Narutoshi	Narutoshi	NNP
cord-001835-0s7ok4uw	5866	39	Kamiya	Kamiya	NNP
cord-001835-0s7ok4uw	5866	40	1	1	CD
cord-001835-0s7ok4uw	5867	1	The	the	DT
cord-001835-0s7ok4uw	5867	2	most	most	JJS
cord-001835-0s7ok4uw	5867	3	time	time	NN
cord-001835-0s7ok4uw	5867	4	-	-	HYPH
cord-001835-0s7ok4uw	5867	5	consuming	consume	VBG
cord-001835-0s7ok4uw	5867	6	part	part	NN
cord-001835-0s7ok4uw	5867	7	of	of	IN
cord-001835-0s7ok4uw	5867	8	molecular	molecular	JJ
cord-001835-0s7ok4uw	5867	9	simulation	simulation	NN
cord-001835-0s7ok4uw	5867	10	is	be	VBZ
cord-001835-0s7ok4uw	5867	11	the	the	DT
cord-001835-0s7ok4uw	5867	12	calculation	calculation	NN
cord-001835-0s7ok4uw	5867	13	of	of	IN
cord-001835-0s7ok4uw	5867	14	long	long	JJ
cord-001835-0s7ok4uw	5867	15	-	-	HYPH
cord-001835-0s7ok4uw	5867	16	range	range	NN
cord-001835-0s7ok4uw	5867	17	interactions	interaction	NNS
cord-001835-0s7ok4uw	5867	18	of	of	IN
cord-001835-0s7ok4uw	5867	19	the	the	DT
cord-001835-0s7ok4uw	5867	20	particles	particle	NNS
cord-001835-0s7ok4uw	5867	21	.	.	.
cord-001835-0s7ok4uw	5868	1	In	in	IN
cord-001835-0s7ok4uw	5868	2	particular	particular	JJ
cord-001835-0s7ok4uw	5868	3	,	,	,
cord-001835-0s7ok4uw	5868	4	appropriate	appropriate	JJ
cord-001835-0s7ok4uw	5868	5	treatment	treatment	NN
cord-001835-0s7ok4uw	5868	6	of	of	IN
cord-001835-0s7ok4uw	5868	7	the	the	DT
cord-001835-0s7ok4uw	5868	8	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	5868	9	interaction	interaction	NN
cord-001835-0s7ok4uw	5868	10	is	be	VBZ
cord-001835-0s7ok4uw	5868	11	critical	critical	JJ
cord-001835-0s7ok4uw	5868	12	,	,	,
cord-001835-0s7ok4uw	5868	13	since	since	IN
cord-001835-0s7ok4uw	5868	14	the	the	DT
cord-001835-0s7ok4uw	5868	15	simple	simple	JJ
cord-001835-0s7ok4uw	5868	16	truncation	truncation	NN
cord-001835-0s7ok4uw	5868	17	can	can	MD
cord-001835-0s7ok4uw	5868	18	not	not	RB
cord-001835-0s7ok4uw	5868	19	be	be	VB
cord-001835-0s7ok4uw	5868	20	used	use	VBN
cord-001835-0s7ok4uw	5868	21	due	due	IN
cord-001835-0s7ok4uw	5868	22	to	to	IN
cord-001835-0s7ok4uw	5868	23	the	the	DT
cord-001835-0s7ok4uw	5868	24	slow	slow	JJ
cord-001835-0s7ok4uw	5868	25	decay	decay	NN
cord-001835-0s7ok4uw	5868	26	of	of	IN
cord-001835-0s7ok4uw	5868	27	the	the	DT
cord-001835-0s7ok4uw	5868	28	Coulombic	Coulombic	NNP
cord-001835-0s7ok4uw	5868	29	function	function	NN
cord-001835-0s7ok4uw	5868	30	.	.	.
cord-001835-0s7ok4uw	5869	1	Thus	thus	RB
cord-001835-0s7ok4uw	5869	2	,	,	,
cord-001835-0s7ok4uw	5869	3	it	-PRON-	PRP
cord-001835-0s7ok4uw	5869	4	is	be	VBZ
cord-001835-0s7ok4uw	5869	5	highly	highly	RB
cord-001835-0s7ok4uw	5869	6	demanded	demand	VBN
cord-001835-0s7ok4uw	5869	7	to	to	TO
cord-001835-0s7ok4uw	5869	8	calculate	calculate	VB
cord-001835-0s7ok4uw	5869	9	the	the	DT
cord-001835-0s7ok4uw	5869	10	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	5869	11	interactions	interaction	NNS
cord-001835-0s7ok4uw	5869	12	with	with	IN
cord-001835-0s7ok4uw	5869	13	high	high	JJ
cord-001835-0s7ok4uw	5869	14	accuracy	accuracy	NN
cord-001835-0s7ok4uw	5869	15	and	and	CC
cord-001835-0s7ok4uw	5869	16	low	low	JJ
cord-001835-0s7ok4uw	5869	17	computational	computational	JJ
cord-001835-0s7ok4uw	5869	18	cost	cost	NN
cord-001835-0s7ok4uw	5869	19	.	.	.
cord-001835-0s7ok4uw	5870	1	For	for	IN
cord-001835-0s7ok4uw	5870	2	this	this	DT
cord-001835-0s7ok4uw	5870	3	purpose	purpose	NN
cord-001835-0s7ok4uw	5870	4	we	-PRON-	PRP
cord-001835-0s7ok4uw	5870	5	have	have	VBP
cord-001835-0s7ok4uw	5870	6	developed	develop	VBN
cord-001835-0s7ok4uw	5870	7	the	the	DT
cord-001835-0s7ok4uw	5870	8	Zero	Zero	NNP
cord-001835-0s7ok4uw	5870	9	-	-	HYPH
cord-001835-0s7ok4uw	5870	10	multipole	multipole	NN
cord-001835-0s7ok4uw	5870	11	(	(	-LRB-
cord-001835-0s7ok4uw	5870	12	ZM	ZM	NNP
cord-001835-0s7ok4uw	5870	13	)	)	-RRB-
cord-001835-0s7ok4uw	5870	14	summation	summation	JJ
cord-001835-0s7ok4uw	5870	15	method	method	NN
cord-001835-0s7ok4uw	5870	16	[	[	-LRB-
cord-001835-0s7ok4uw	5870	17	1	1	CD
cord-001835-0s7ok4uw	5870	18	]	]	-RRB-
cord-001835-0s7ok4uw	5870	19	.	.	.
cord-001835-0s7ok4uw	5871	1	In	in	IN
cord-001835-0s7ok4uw	5871	2	this	this	DT
cord-001835-0s7ok4uw	5871	3	method	method	NN
cord-001835-0s7ok4uw	5871	4	the	the	DT
cord-001835-0s7ok4uw	5871	5	artificial	artificial	JJ
cord-001835-0s7ok4uw	5871	6	periodic	periodic	JJ
cord-001835-0s7ok4uw	5871	7	boundary	boundary	JJ
cord-001835-0s7ok4uw	5871	8	conditions	condition	NNS
cord-001835-0s7ok4uw	5871	9	are	be	VBP
cord-001835-0s7ok4uw	5871	10	not	not	RB
cord-001835-0s7ok4uw	5871	11	necessary	necessary	JJ
cord-001835-0s7ok4uw	5871	12	and	and	CC
cord-001835-0s7ok4uw	5871	13	the	the	DT
cord-001835-0s7ok4uw	5871	14	Fourier	Fourier	NNP
cord-001835-0s7ok4uw	5871	15	part	part	NN
cord-001835-0s7ok4uw	5871	16	evaluations	evaluation	NNS
cord-001835-0s7ok4uw	5871	17	are	be	VBP
cord-001835-0s7ok4uw	5871	18	not	not	RB
cord-001835-0s7ok4uw	5871	19	needed	need	VBN
cord-001835-0s7ok4uw	5871	20	,	,	,
cord-001835-0s7ok4uw	5871	21	in	in	IN
cord-001835-0s7ok4uw	5871	22	contrast	contrast	NN
cord-001835-0s7ok4uw	5871	23	to	to	IN
cord-001835-0s7ok4uw	5871	24	the	the	DT
cord-001835-0s7ok4uw	5871	25	conventional	conventional	JJ
cord-001835-0s7ok4uw	5871	26	Ewald	Ewald	NNP
cord-001835-0s7ok4uw	5871	27	-	-	HYPH
cord-001835-0s7ok4uw	5871	28	based	base	VBN
cord-001835-0s7ok4uw	5871	29	methods	method	NNS
cord-001835-0s7ok4uw	5871	30	.	.	.
cord-001835-0s7ok4uw	5872	1	Instead	instead	RB
cord-001835-0s7ok4uw	5872	2	,	,	,
cord-001835-0s7ok4uw	5872	3	a	a	DT
cord-001835-0s7ok4uw	5872	4	pairwise	pairwise	JJ
cord-001835-0s7ok4uw	5872	5	function	function	NN
cord-001835-0s7ok4uw	5872	6	that	that	WDT
cord-001835-0s7ok4uw	5872	7	is	be	VBZ
cord-001835-0s7ok4uw	5872	8	suitably	suitably	RB
cord-001835-0s7ok4uw	5872	9	redefined	redefine	VBN
cord-001835-0s7ok4uw	5872	10	from	from	IN
cord-001835-0s7ok4uw	5872	11	the	the	DT
cord-001835-0s7ok4uw	5872	12	Coulombic	Coulombic	NNP
cord-001835-0s7ok4uw	5872	13	function	function	NN
cord-001835-0s7ok4uw	5872	14	is	be	VBZ
cord-001835-0s7ok4uw	5872	15	used	use	VBN
cord-001835-0s7ok4uw	5872	16	with	with	IN
cord-001835-0s7ok4uw	5872	17	a	a	DT
cord-001835-0s7ok4uw	5872	18	cutoff	cutoff	NN
cord-001835-0s7ok4uw	5872	19	scheme	scheme	NN
cord-001835-0s7ok4uw	5872	20	.	.	.
cord-001835-0s7ok4uw	5873	1	The	the	DT
cord-001835-0s7ok4uw	5873	2	underling	underling	JJ
cord-001835-0s7ok4uw	5873	3	physical	physical	JJ
cord-001835-0s7ok4uw	5873	4	idea	idea	NN
cord-001835-0s7ok4uw	5873	5	is	be	VBZ
cord-001835-0s7ok4uw	5873	6	simple	simple	JJ
cord-001835-0s7ok4uw	5873	7	:	:	:
cord-001835-0s7ok4uw	5873	8	(	(	-LRB-
cord-001835-0s7ok4uw	5873	9	a	a	LS
cord-001835-0s7ok4uw	5873	10	)	)	-RRB-
cord-001835-0s7ok4uw	5873	11	in	in	IN
cord-001835-0s7ok4uw	5873	12	a	a	DT
cord-001835-0s7ok4uw	5873	13	biological	biological	JJ
cord-001835-0s7ok4uw	5873	14	system	system	NN
cord-001835-0s7ok4uw	5873	15	,	,	,
cord-001835-0s7ok4uw	5873	16	a	a	DT
cord-001835-0s7ok4uw	5873	17	particle	particle	NN
cord-001835-0s7ok4uw	5873	18	conformation	conformation	NN
cord-001835-0s7ok4uw	5873	19	for	for	IN
cord-001835-0s7ok4uw	5873	20	which	which	WDT
cord-001835-0s7ok4uw	5873	21	the	the	DT
cord-001835-0s7ok4uw	5873	22	electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	5873	23	interactions	interaction	NNS
cord-001835-0s7ok4uw	5873	24	are	be	VBP
cord-001835-0s7ok4uw	5873	25	well	well	RB
cord-001835-0s7ok4uw	5873	26	cancelled	cancel	VBN
cord-001835-0s7ok4uw	5873	27	is	be	VBZ
cord-001835-0s7ok4uw	5873	28	more	more	RBR
cord-001835-0s7ok4uw	5873	29	stable	stable	JJ
cord-001835-0s7ok4uw	5873	30	than	than	IN
cord-001835-0s7ok4uw	5873	31	other	other	JJ
cord-001835-0s7ok4uw	5873	32	conformations	conformation	NNS
cord-001835-0s7ok4uw	5873	33	[	[	-LRB-
cord-001835-0s7ok4uw	5873	34	2	2	CD
cord-001835-0s7ok4uw	5873	35	]	]	-RRB-
cord-001835-0s7ok4uw	5873	36	;	;	:
cord-001835-0s7ok4uw	5873	37	(	(	-LRB-
cord-001835-0s7ok4uw	5873	38	b	b	NN
cord-001835-0s7ok4uw	5873	39	)	)	-RRB-
cord-001835-0s7ok4uw	5873	40	since	since	IN
cord-001835-0s7ok4uw	5873	41	such	such	JJ
cord-001835-0s7ok4uw	5873	42	well	well	RB
cord-001835-0s7ok4uw	5873	43	-	-	HYPH
cord-001835-0s7ok4uw	5873	44	cancelled	cancel	VBN
cord-001835-0s7ok4uw	5873	45	conformations	conformation	NNS
cord-001835-0s7ok4uw	5873	46	are	be	VBP
cord-001835-0s7ok4uw	5873	47	essentially	essentially	RB
cord-001835-0s7ok4uw	5873	48	physical	physical	JJ
cord-001835-0s7ok4uw	5873	49	,	,	,
cord-001835-0s7ok4uw	5873	50	we	-PRON-	PRP
cord-001835-0s7ok4uw	5873	51	should	should	MD
cord-001835-0s7ok4uw	5873	52	clip	clip	VB
cord-001835-0s7ok4uw	5873	53	a	a	DT
cord-001835-0s7ok4uw	5873	54	subset	subset	NN
cord-001835-0s7ok4uw	5873	55	of	of	IN
cord-001835-0s7ok4uw	5873	56	such	such	PDT
cord-001835-0s7ok4uw	5873	57	a	a	DT
cord-001835-0s7ok4uw	5873	58	conformation	conformation	NN
cord-001835-0s7ok4uw	5873	59	out	out	IN
cord-001835-0s7ok4uw	5873	60	of	of	IN
cord-001835-0s7ok4uw	5873	61	the	the	DT
cord-001835-0s7ok4uw	5873	62	conformation	conformation	NN
cord-001835-0s7ok4uw	5873	63	within	within	IN
cord-001835-0s7ok4uw	5873	64	an	an	DT
cord-001835-0s7ok4uw	5873	65	ad	ad	NN
cord-001835-0s7ok4uw	5873	66	-	-	HYPH
cord-001835-0s7ok4uw	5873	67	hoc	hoc	FW
cord-001835-0s7ok4uw	5873	68	given	give	VBN
cord-001835-0s7ok4uw	5873	69	cutoff	cutoff	NN
cord-001835-0s7ok4uw	5873	70	sphere	sphere	NN
cord-001835-0s7ok4uw	5873	71	and	and	CC
cord-001835-0s7ok4uw	5873	72	calculate	calculate	VB
cord-001835-0s7ok4uw	5873	73	the	the	DT
cord-001835-0s7ok4uw	5873	74	interactions	interaction	NNS
cord-001835-0s7ok4uw	5873	75	only	only	RB
cord-001835-0s7ok4uw	5873	76	from	from	IN
cord-001835-0s7ok4uw	5873	77	this	this	DT
cord-001835-0s7ok4uw	5873	78	subset	subset	NN
cord-001835-0s7ok4uw	5873	79	.	.	.
cord-001835-0s7ok4uw	5874	1	This	this	DT
cord-001835-0s7ok4uw	5874	2	idea	idea	NN
cord-001835-0s7ok4uw	5874	3	is	be	VBZ
cord-001835-0s7ok4uw	5874	4	realized	realize	VBN
cord-001835-0s7ok4uw	5874	5	by	by	IN
cord-001835-0s7ok4uw	5874	6	a	a	DT
cord-001835-0s7ok4uw	5874	7	rigid	rigid	JJ
cord-001835-0s7ok4uw	5874	8	mathematical	mathematical	JJ
cord-001835-0s7ok4uw	5874	9	consideration	consideration	NN
cord-001835-0s7ok4uw	5874	10	that	that	WDT
cord-001835-0s7ok4uw	5874	11	leads	lead	VBZ
cord-001835-0s7ok4uw	5874	12	to	to	IN
cord-001835-0s7ok4uw	5874	13	the	the	DT
cord-001835-0s7ok4uw	5874	14	deformation	deformation	NN
cord-001835-0s7ok4uw	5874	15	of	of	IN
cord-001835-0s7ok4uw	5874	16	the	the	DT
cord-001835-0s7ok4uw	5874	17	Coulombic	Coulombic	NNP
cord-001835-0s7ok4uw	5874	18	function	function	NN
cord-001835-0s7ok4uw	5874	19	.	.	.
cord-001835-0s7ok4uw	5875	1	The	the	DT
cord-001835-0s7ok4uw	5875	2	efficiency	efficiency	NN
cord-001835-0s7ok4uw	5875	3	of	of	IN
cord-001835-0s7ok4uw	5875	4	the	the	DT
cord-001835-0s7ok4uw	5875	5	ZM	ZM	NNP
cord-001835-0s7ok4uw	5875	6	method	method	NN
cord-001835-0s7ok4uw	5875	7	has	have	VBZ
cord-001835-0s7ok4uw	5875	8	been	be	VBN
cord-001835-0s7ok4uw	5875	9	validated	validate	VBN
cord-001835-0s7ok4uw	5875	10	in	in	IN
cord-001835-0s7ok4uw	5875	11	applications	application	NNS
cord-001835-0s7ok4uw	5875	12	to	to	IN
cord-001835-0s7ok4uw	5875	13	fundamental	fundamental	JJ
cord-001835-0s7ok4uw	5875	14	systems	system	NNS
cord-001835-0s7ok4uw	5875	15	Sema	Sema	NNP
cord-001835-0s7ok4uw	5875	16	3A	3A	NNP
cord-001835-0s7ok4uw	5875	17	)	)	-RRB-
cord-001835-0s7ok4uw	5875	18	is	be	VBZ
cord-001835-0s7ok4uw	5875	19	a	a	DT
cord-001835-0s7ok4uw	5875	20	protein	protein	NN
cord-001835-0s7ok4uw	5875	21	originally	originally	RB
cord-001835-0s7ok4uw	5875	22	described	describe	VBN
cord-001835-0s7ok4uw	5875	23	as	as	IN
cord-001835-0s7ok4uw	5875	24	an	an	DT
cord-001835-0s7ok4uw	5875	25	axonal	axonal	JJ
cord-001835-0s7ok4uw	5875	26	chemorepellent	chemorepellent	NN
cord-001835-0s7ok4uw	5875	27	cue	cue	NN
cord-001835-0s7ok4uw	5875	28	involved	involve	VBN
cord-001835-0s7ok4uw	5875	29	in	in	IN
cord-001835-0s7ok4uw	5875	30	many	many	JJ
cord-001835-0s7ok4uw	5875	31	physiological	physiological	JJ
cord-001835-0s7ok4uw	5875	32	processes	process	NNS
cord-001835-0s7ok4uw	5875	33	ranging	range	VBG
cord-001835-0s7ok4uw	5875	34	from	from	IN
cord-001835-0s7ok4uw	5875	35	embryonic	embryonic	JJ
cord-001835-0s7ok4uw	5875	36	development	development	NN
cord-001835-0s7ok4uw	5875	37	to	to	IN
cord-001835-0s7ok4uw	5875	38	bone	bone	NN
cord-001835-0s7ok4uw	5875	39	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	5875	40	or	or	CC
cord-001835-0s7ok4uw	5875	41	immune	immune	JJ
cord-001835-0s7ok4uw	5875	42	responses	response	NNS
cord-001835-0s7ok4uw	5876	1	Sema3A	Sema3A	NNP
cord-001835-0s7ok4uw	5876	2	signal	signal	NN
cord-001835-0s7ok4uw	5876	3	transduction	transduction	NN
cord-001835-0s7ok4uw	5876	4	requires	require	VBZ
cord-001835-0s7ok4uw	5876	5	the	the	DT
cord-001835-0s7ok4uw	5876	6	formation	formation	NN
cord-001835-0s7ok4uw	5876	7	of	of	IN
cord-001835-0s7ok4uw	5876	8	a	a	DT
cord-001835-0s7ok4uw	5876	9	heteromeric	heteromeric	JJ
cord-001835-0s7ok4uw	5876	10	complex	complex	NN
cord-001835-0s7ok4uw	5876	11	with	with	IN
cord-001835-0s7ok4uw	5876	12	Neuropilin-1	Neuropilin-1	NNP
cord-001835-0s7ok4uw	5876	13	(	(	-LRB-
cord-001835-0s7ok4uw	5876	14	Nrp1	Nrp1	NNP
cord-001835-0s7ok4uw	5876	15	)	)	-RRB-
cord-001835-0s7ok4uw	5876	16	and	and	CC
cord-001835-0s7ok4uw	5876	17	PlexinA	plexina	RB
cord-001835-0s7ok4uw	5876	18	[	[	-LRB-
cord-001835-0s7ok4uw	5876	19	2	2	CD
cord-001835-0s7ok4uw	5876	20	]	]	-RRB-
cord-001835-0s7ok4uw	5876	21	.	.	.
cord-001835-0s7ok4uw	5877	1	In	in	IN
cord-001835-0s7ok4uw	5877	2	addition	addition	NN
cord-001835-0s7ok4uw	5877	3	,	,	,
cord-001835-0s7ok4uw	5877	4	Sema3A	Sema3A	NNP
cord-001835-0s7ok4uw	5877	5	interaction	interaction	NN
cord-001835-0s7ok4uw	5877	6	with	with	IN
cord-001835-0s7ok4uw	5877	7	Nrp1	Nrp1	NNP
cord-001835-0s7ok4uw	5877	8	is	be	VBZ
cord-001835-0s7ok4uw	5877	9	modulated	modulate	VBN
cord-001835-0s7ok4uw	5877	10	by	by	IN
cord-001835-0s7ok4uw	5877	11	the	the	DT
cord-001835-0s7ok4uw	5877	12	furin	furin	NN
cord-001835-0s7ok4uw	5877	13	protease	protease	NN
cord-001835-0s7ok4uw	5877	14	cleavage	cleavage	NN
cord-001835-0s7ok4uw	5877	15	at	at	IN
cord-001835-0s7ok4uw	5877	16	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5877	17	C	c	NN
cord-001835-0s7ok4uw	5877	18	-	-	HYPH
cord-001835-0s7ok4uw	5877	19	terminal	terminal	NN
cord-001835-0s7ok4uw	5877	20	basic	basic	JJ
cord-001835-0s7ok4uw	5877	21	domain	domain	NN
cord-001835-0s7ok4uw	5878	1	This	this	DT
cord-001835-0s7ok4uw	5878	2	C	c	NN
cord-001835-0s7ok4uw	5878	3	-	-	HYPH
cord-001835-0s7ok4uw	5878	4	terminal	terminal	JJ
cord-001835-0s7ok4uw	5878	5	basic	basic	JJ
cord-001835-0s7ok4uw	5878	6	domain	domain	NN
cord-001835-0s7ok4uw	5878	7	has	have	VBZ
cord-001835-0s7ok4uw	5878	8	also	also	RB
cord-001835-0s7ok4uw	5878	9	been	be	VBN
cord-001835-0s7ok4uw	5878	10	suggested	suggest	VBN
cord-001835-0s7ok4uw	5878	11	to	to	TO
cord-001835-0s7ok4uw	5878	12	mediate	mediate	VB
cord-001835-0s7ok4uw	5878	13	the	the	DT
cord-001835-0s7ok4uw	5878	14	binding	binding	NN
cord-001835-0s7ok4uw	5878	15	to	to	IN
cord-001835-0s7ok4uw	5878	16	glycosaminoglycans	glycosaminoglycan	NNS
cord-001835-0s7ok4uw	5878	17	(	(	-LRB-
cord-001835-0s7ok4uw	5878	18	GAGs	GAGs	NNP
cord-001835-0s7ok4uw	5878	19	)	)	-RRB-
cord-001835-0s7ok4uw	5878	20	,	,	,
cord-001835-0s7ok4uw	5878	21	an	an	DT
cord-001835-0s7ok4uw	5878	22	association	association	NN
cord-001835-0s7ok4uw	5878	23	that	that	WDT
cord-001835-0s7ok4uw	5878	24	locates	locate	VBZ
cord-001835-0s7ok4uw	5878	25	Sema3A	Sema3A	NNP
cord-001835-0s7ok4uw	5878	26	to	to	IN
cord-001835-0s7ok4uw	5878	27	perineuronal	perineuronal	JJ
cord-001835-0s7ok4uw	5878	28	nets	net	NNS
cord-001835-0s7ok4uw	5878	29	and	and	CC
cord-001835-0s7ok4uw	5878	30	enhances	enhance	VBZ
cord-001835-0s7ok4uw	5878	31	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5878	32	function	function	NN
cord-001835-0s7ok4uw	5878	33	in	in	IN
cord-001835-0s7ok4uw	5878	34	restricting	restrict	VBG
cord-001835-0s7ok4uw	5878	35	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	5878	36	plasticity	plasticity	NN
cord-001835-0s7ok4uw	5878	37	and	and	CC
cord-001835-0s7ok4uw	5878	38	inhibiting	inhibit	VBG
cord-001835-0s7ok4uw	5878	39	axonal	axonal	JJ
cord-001835-0s7ok4uw	5878	40	regeneration	regeneration	NN
cord-001835-0s7ok4uw	5878	41	in	in	IN
cord-001835-0s7ok4uw	5878	42	the	the	DT
cord-001835-0s7ok4uw	5878	43	central	central	JJ
cord-001835-0s7ok4uw	5878	44	nervous	nervous	JJ
cord-001835-0s7ok4uw	5878	45	system	system	NN
cord-001835-0s7ok4uw	5878	46	Two	two	CD
cord-001835-0s7ok4uw	5878	47	peptides	peptide	NNS
cord-001835-0s7ok4uw	5878	48	corresponding	correspond	VBG
cord-001835-0s7ok4uw	5878	49	to	to	IN
cord-001835-0s7ok4uw	5878	50	the	the	DT
cord-001835-0s7ok4uw	5878	51	highly	highly	RB
cord-001835-0s7ok4uw	5878	52	positively	positively	RB
cord-001835-0s7ok4uw	5878	53	charged	charge	VBN
cord-001835-0s7ok4uw	5878	54	regions	region	NNS
cord-001835-0s7ok4uw	5878	55	on	on	IN
cord-001835-0s7ok4uw	5878	56	the	the	DT
cord-001835-0s7ok4uw	5878	57	domain	domain	NN
cord-001835-0s7ok4uw	5878	58	were	be	VBD
cord-001835-0s7ok4uw	5878	59	shown	show	VBN
cord-001835-0s7ok4uw	5878	60	to	to	TO
cord-001835-0s7ok4uw	5878	61	bind	bind	VB
cord-001835-0s7ok4uw	5878	62	to	to	IN
cord-001835-0s7ok4uw	5878	63	immobilized	immobilize	VBN
cord-001835-0s7ok4uw	5878	64	heparin	heparin	NN
cord-001835-0s7ok4uw	5878	65	by	by	IN
cord-001835-0s7ok4uw	5878	66	surface	surface	NN
cord-001835-0s7ok4uw	5878	67	plasmon	plasmon	JJ
cord-001835-0s7ok4uw	5878	68	resonance	resonance	NN
cord-001835-0s7ok4uw	5878	69	(	(	-LRB-
cord-001835-0s7ok4uw	5878	70	SPR	SPR	NNP
cord-001835-0s7ok4uw	5878	71	)	)	-RRB-
cord-001835-0s7ok4uw	5878	72	and	and	CC
cord-001835-0s7ok4uw	5878	73	the	the	DT
cord-001835-0s7ok4uw	5878	74	affinity	affinity	NN
cord-001835-0s7ok4uw	5878	75	dramatically	dramatically	RB
cord-001835-0s7ok4uw	5878	76	increased	increase	VBD
cord-001835-0s7ok4uw	5878	77	when	when	WRB
cord-001835-0s7ok4uw	5878	78	the	the	DT
cord-001835-0s7ok4uw	5878	79	complete	complete	JJ
cord-001835-0s7ok4uw	5878	80	domain	domain	NN
cord-001835-0s7ok4uw	5878	81	was	be	VBD
cord-001835-0s7ok4uw	5878	82	assayed	assay	VBN
cord-001835-0s7ok4uw	5878	83	.	.	.
cord-001835-0s7ok4uw	5879	1	The	the	DT
cord-001835-0s7ok4uw	5879	2	binding	binding	NN
cord-001835-0s7ok4uw	5879	3	was	be	VBD
cord-001835-0s7ok4uw	5879	4	confirmed	confirm	VBN
cord-001835-0s7ok4uw	5879	5	by	by	IN
cord-001835-0s7ok4uw	5879	6	nuclear	nuclear	JJ
cord-001835-0s7ok4uw	5879	7	magnetic	magnetic	JJ
cord-001835-0s7ok4uw	5879	8	resonance	resonance	NN
cord-001835-0s7ok4uw	5879	9	(	(	-LRB-
cord-001835-0s7ok4uw	5879	10	NMR	NMR	NNP
cord-001835-0s7ok4uw	5879	11	)	)	-RRB-
cord-001835-0s7ok4uw	5879	12	and	and	CC
cord-001835-0s7ok4uw	5879	13	Circular	Circular	NNP
cord-001835-0s7ok4uw	5879	14	Dichroism	Dichroism	NNP
cord-001835-0s7ok4uw	5879	15	(	(	-LRB-
cord-001835-0s7ok4uw	5879	16	CD	cd	NN
cord-001835-0s7ok4uw	5879	17	)	)	-RRB-
cord-001835-0s7ok4uw	5880	1	The	the	DT
cord-001835-0s7ok4uw	5880	2	conserved	conserve	VBN
cord-001835-0s7ok4uw	5880	3	cysteine	cysteine	NN
cord-001835-0s7ok4uw	5880	4	within	within	IN
cord-001835-0s7ok4uw	5880	5	this	this	DT
cord-001835-0s7ok4uw	5880	6	motif	motif	NN
cord-001835-0s7ok4uw	5880	7	,	,	,
cord-001835-0s7ok4uw	5880	8	necessary	necessary	JJ
cord-001835-0s7ok4uw	5880	9	for	for	IN
cord-001835-0s7ok4uw	5880	10	the	the	DT
cord-001835-0s7ok4uw	5880	11	dimerization	dimerization	NN
cord-001835-0s7ok4uw	5880	12	of	of	IN
cord-001835-0s7ok4uw	5880	13	Sema3A	Sema3A	NNP
cord-001835-0s7ok4uw	5880	14	[	[	-LRB-
cord-001835-0s7ok4uw	5880	15	7	7	CD
cord-001835-0s7ok4uw	5880	16	]	]	-RRB-
cord-001835-0s7ok4uw	5880	17	,	,	,
cord-001835-0s7ok4uw	5880	18	is	be	VBZ
cord-001835-0s7ok4uw	5880	19	also	also	RB
cord-001835-0s7ok4uw	5880	20	critical	critical	JJ
cord-001835-0s7ok4uw	5880	21	for	for	IN
cord-001835-0s7ok4uw	5880	22	the	the	DT
cord-001835-0s7ok4uw	5880	23	helix	helix	NN
cord-001835-0s7ok4uw	5880	24	formation	formation	NN
cord-001835-0s7ok4uw	5880	25	.	.	.
cord-001835-0s7ok4uw	5881	1	In	in	IN
cord-001835-0s7ok4uw	5881	2	addition	addition	NN
cord-001835-0s7ok4uw	5881	3	,	,	,
cord-001835-0s7ok4uw	5881	4	fluorescence	fluorescence	NN
cord-001835-0s7ok4uw	5881	5	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	5881	6	studies	study	NNS
cord-001835-0s7ok4uw	5881	7	showed	show	VBD
cord-001835-0s7ok4uw	5881	8	that	that	IN
cord-001835-0s7ok4uw	5881	9	the	the	DT
cord-001835-0s7ok4uw	5881	10	N	n	CD
cord-001835-0s7ok4uw	5881	11	-	-	HYPH
cord-001835-0s7ok4uw	5881	12	terminal	terminal	NN
cord-001835-0s7ok4uw	5881	13	region	region	NN
cord-001835-0s7ok4uw	5881	14	also	also	RB
cord-001835-0s7ok4uw	5881	15	has	have	VBZ
cord-001835-0s7ok4uw	5881	16	a	a	DT
cord-001835-0s7ok4uw	5881	17	contribution	contribution	NN
cord-001835-0s7ok4uw	5881	18	in	in	IN
cord-001835-0s7ok4uw	5881	19	the	the	DT
cord-001835-0s7ok4uw	5881	20	binding	binding	NN
cord-001835-0s7ok4uw	5881	21	to	to	IN
cord-001835-0s7ok4uw	5881	22	GAGs	gag	NNS
cord-001835-0s7ok4uw	5881	23	.	.	.
cord-001835-0s7ok4uw	5882	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5882	2	acknowledge	acknowledge	VBP
cord-001835-0s7ok4uw	5882	3	the	the	DT
cord-001835-0s7ok4uw	5882	4	financial	financial	JJ
cord-001835-0s7ok4uw	5882	5	support	support	NN
cord-001835-0s7ok4uw	5882	6	from	from	IN
cord-001835-0s7ok4uw	5882	7	the	the	DT
cord-001835-0s7ok4uw	5882	8	European	European	NNP
cord-001835-0s7ok4uw	5882	9	Union	Union	NNP
cord-001835-0s7ok4uw	5882	10	Seventh	Seventh	NNP
cord-001835-0s7ok4uw	5882	11	Framework	Framework	NNP
cord-001835-0s7ok4uw	5882	12	Programme	Programme	NNP
cord-001835-0s7ok4uw	5882	13	(	(	-LRB-
cord-001835-0s7ok4uw	5882	14	FP7/2007	FP7/2007	NNP
cord-001835-0s7ok4uw	5882	15	-	-	HYPH
cord-001835-0s7ok4uw	5882	16	2013	2013	CD
cord-001835-0s7ok4uw	5882	17	)	)	-RRB-
cord-001835-0s7ok4uw	5882	18	under	under	IN
cord-001835-0s7ok4uw	5882	19	the	the	DT
cord-001835-0s7ok4uw	5882	20	Project	Project	NNP
cord-001835-0s7ok4uw	5882	21	VISION	vision	NN
cord-001835-0s7ok4uw	5882	22	Semaphorin	Semaphorin	NNP
cord-001835-0s7ok4uw	5882	23	3A	3a	NN
cord-001835-0s7ok4uw	5882	24	:	:	:
cord-001835-0s7ok4uw	5882	25	A	a	DT
cord-001835-0s7ok4uw	5882	26	new	new	JJ
cord-001835-0s7ok4uw	5882	27	player	player	NN
cord-001835-0s7ok4uw	5882	28	in	in	IN
cord-001835-0s7ok4uw	5882	29	bone	bone	NN
cord-001835-0s7ok4uw	5882	30	remodeling	remodel	VBG
cord-001835-0s7ok4uw	5882	31	Neuropilins	Neuropilins	NNPS
cord-001835-0s7ok4uw	5882	32	lock	lock	VBP
cord-001835-0s7ok4uw	5882	33	secreted	secrete	VBN
cord-001835-0s7ok4uw	5882	34	semaphorins	semaphorin	NNS
cord-001835-0s7ok4uw	5882	35	onto	onto	IN
cord-001835-0s7ok4uw	5882	36	plexins	plexin	NNS
cord-001835-0s7ok4uw	5882	37	in	in	IN
cord-001835-0s7ok4uw	5882	38	a	a	DT
cord-001835-0s7ok4uw	5882	39	ternary	ternary	JJ
cord-001835-0s7ok4uw	5882	40	signaling	signal	VBG
cord-001835-0s7ok4uw	5882	41	complex	complex	JJ
cord-001835-0s7ok4uw	5882	42	Furin	Furin	NNP
cord-001835-0s7ok4uw	5882	43	processing	processing	NN
cord-001835-0s7ok4uw	5882	44	of	of	IN
cord-001835-0s7ok4uw	5882	45	semaphorin	semaphorin	NNP
cord-001835-0s7ok4uw	5882	46	3F	3F	NNP
cord-001835-0s7ok4uw	5882	47	determines	determine	VBZ
cord-001835-0s7ok4uw	5882	48	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5882	49	anti	anti	JJ
cord-001835-0s7ok4uw	5882	50	-	-	JJ
cord-001835-0s7ok4uw	5882	51	angiogenic	angiogenic	JJ
cord-001835-0s7ok4uw	5882	52	activity	activity	NN
cord-001835-0s7ok4uw	5882	53	by	by	IN
cord-001835-0s7ok4uw	5882	54	regulating	regulate	VBG
cord-001835-0s7ok4uw	5882	55	direct	direct	JJ
cord-001835-0s7ok4uw	5882	56	binding	binding	NN
cord-001835-0s7ok4uw	5882	57	and	and	CC
cord-001835-0s7ok4uw	5882	58	competition	competition	NN
cord-001835-0s7ok4uw	5882	59	for	for	IN
cord-001835-0s7ok4uw	5882	60	neuropilin	neuropilin	NNP
cord-001835-0s7ok4uw	5882	61	Semaphorin	Semaphorin	NNP
cord-001835-0s7ok4uw	5882	62	3A	3A	NNP
cord-001835-0s7ok4uw	5882	63	displays	display	VBZ
cord-001835-0s7ok4uw	5882	64	a	a	DT
cord-001835-0s7ok4uw	5882	65	punctate	punctate	NN
cord-001835-0s7ok4uw	5882	66	distribution	distribution	NN
cord-001835-0s7ok4uw	5882	67	on	on	IN
cord-001835-0s7ok4uw	5882	68	the	the	DT
cord-001835-0s7ok4uw	5882	69	surface	surface	NN
cord-001835-0s7ok4uw	5882	70	of	of	IN
cord-001835-0s7ok4uw	5882	71	neuronal	neuronal	JJ
cord-001835-0s7ok4uw	5882	72	cells	cell	NNS
cord-001835-0s7ok4uw	5882	73	and	and	CC
cord-001835-0s7ok4uw	5882	74	interacts	interact	VBZ
cord-001835-0s7ok4uw	5882	75	with	with	IN
cord-001835-0s7ok4uw	5882	76	proteoglycans	proteoglycan	NNS
cord-001835-0s7ok4uw	5882	77	in	in	IN
cord-001835-0s7ok4uw	5882	78	the	the	DT
cord-001835-0s7ok4uw	5882	79	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	5882	80	matrix	matrix	NN
cord-001835-0s7ok4uw	5882	81	Semaphorin	Semaphorin	NNP
cord-001835-0s7ok4uw	5882	82	3A	3A	NNP
cord-001835-0s7ok4uw	5883	1	binds	bind	VBZ
cord-001835-0s7ok4uw	5883	2	to	to	IN
cord-001835-0s7ok4uw	5883	3	the	the	DT
cord-001835-0s7ok4uw	5883	4	perineuronal	perineuronal	JJ
cord-001835-0s7ok4uw	5883	5	nets	net	NNS
cord-001835-0s7ok4uw	5883	6	via	via	IN
cord-001835-0s7ok4uw	5883	7	chondroitin	chondroitin	NN
cord-001835-0s7ok4uw	5883	8	sulfate	sulfate	NN
cord-001835-0s7ok4uw	5883	9	type	type	NN
cord-001835-0s7ok4uw	5883	10	E	e	NN
cord-001835-0s7ok4uw	5883	11	motifs	motif	NNS
cord-001835-0s7ok4uw	5883	12	in	in	IN
cord-001835-0s7ok4uw	5883	13	rodent	rodent	NN
cord-001835-0s7ok4uw	5883	14	brains	brain	NNS
cord-001835-0s7ok4uw	5884	1	Mechanistic	mechanistic	JJ
cord-001835-0s7ok4uw	5884	2	basis	basis	NN
cord-001835-0s7ok4uw	5884	3	for	for	IN
cord-001835-0s7ok4uw	5884	4	the	the	DT
cord-001835-0s7ok4uw	5884	5	potent	potent	JJ
cord-001835-0s7ok4uw	5884	6	anti	anti	JJ
cord-001835-0s7ok4uw	5884	7	-	-	JJ
cord-001835-0s7ok4uw	5884	8	angiogenic	angiogenic	JJ
cord-001835-0s7ok4uw	5884	9	activity	activity	NN
cord-001835-0s7ok4uw	5884	10	of	of	IN
cord-001835-0s7ok4uw	5884	11	semaphorin	semaphorin	NN
cord-001835-0s7ok4uw	5884	12	3F.	3f.	CD
cord-001835-0s7ok4uw	5884	13	Biochemistry	Biochemistry	NNP
cord-001835-0s7ok4uw	5884	14	Collapsin-1	Collapsin-1	NNP
cord-001835-0s7ok4uw	5884	15	covalently	covalently	RB
cord-001835-0s7ok4uw	5884	16	dimerizes	dimerizes	JJ
cord-001835-0s7ok4uw	5884	17	,	,	,
cord-001835-0s7ok4uw	5884	18	and	and	CC
cord-001835-0s7ok4uw	5884	19	dimerization	dimerization	NN
cord-001835-0s7ok4uw	5884	20	is	be	VBZ
cord-001835-0s7ok4uw	5884	21	necessary	necessary	JJ
cord-001835-0s7ok4uw	5884	22	for	for	IN
cord-001835-0s7ok4uw	5884	23	collapsing	collapse	VBG
cord-001835-0s7ok4uw	5884	24	activity	activity	NN
cord-001835-0s7ok4uw	5884	25	Prior	prior	RB
cord-001835-0s7ok4uw	5884	26	attempts	attempt	VBZ
cord-001835-0s7ok4uw	5884	27	to	to	TO
cord-001835-0s7ok4uw	5884	28	create	create	VB
cord-001835-0s7ok4uw	5884	29	functionally	functionally	RB
cord-001835-0s7ok4uw	5884	30	relevant	relevant	JJ
cord-001835-0s7ok4uw	5884	31	groupings	grouping	NNS
cord-001835-0s7ok4uw	5884	32	of	of	IN
cord-001835-0s7ok4uw	5884	33	proteins	protein	NNS
cord-001835-0s7ok4uw	5884	34	in	in	IN
cord-001835-0s7ok4uw	5884	35	the	the	DT
cord-001835-0s7ok4uw	5884	36	Crotonase	Crotonase	NNP
cord-001835-0s7ok4uw	5884	37	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5884	38	suggest	suggest	VBP
cord-001835-0s7ok4uw	5884	39	that	that	IN
cord-001835-0s7ok4uw	5884	40	this	this	DT
cord-001835-0s7ok4uw	5884	41	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5884	42	is	be	VBZ
cord-001835-0s7ok4uw	5884	43	difficult	difficult	JJ
cord-001835-0s7ok4uw	5884	44	to	to	TO
cord-001835-0s7ok4uw	5884	45	cluster	cluster	VB
cord-001835-0s7ok4uw	5884	46	functionally	functionally	RB
cord-001835-0s7ok4uw	5884	47	due	due	JJ
cord-001835-0s7ok4uw	5884	48	in	in	IN
cord-001835-0s7ok4uw	5884	49	part	part	NN
cord-001835-0s7ok4uw	5884	50	to	to	IN
cord-001835-0s7ok4uw	5884	51	the	the	DT
cord-001835-0s7ok4uw	5884	52	functionally	functionally	RB
cord-001835-0s7ok4uw	5884	53	diverse	diverse	JJ
cord-001835-0s7ok4uw	5884	54	nature	nature	NN
cord-001835-0s7ok4uw	5884	55	of	of	IN
cord-001835-0s7ok4uw	5884	56	the	the	DT
cord-001835-0s7ok4uw	5884	57	protein	protein	NN
cord-001835-0s7ok4uw	5884	58	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5884	59	.	.	.
cord-001835-0s7ok4uw	5885	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5885	2	have	have	VBP
cord-001835-0s7ok4uw	5885	3	developed	develop	VBN
cord-001835-0s7ok4uw	5885	4	two	two	CD
cord-001835-0s7ok4uw	5885	5	novel	novel	JJ
cord-001835-0s7ok4uw	5885	6	procedures	procedure	NNS
cord-001835-0s7ok4uw	5885	7	to	to	TO
cord-001835-0s7ok4uw	5885	8	combat	combat	VB
cord-001835-0s7ok4uw	5885	9	this	this	DT
cord-001835-0s7ok4uw	5885	10	difficulty	difficulty	NN
cord-001835-0s7ok4uw	5885	11	:	:	:
cord-001835-0s7ok4uw	5886	1	TuLIP	TuLIP	NNP
cord-001835-0s7ok4uw	5886	2	(	(	-LRB-
cord-001835-0s7ok4uw	5886	3	Two	two	CD
cord-001835-0s7ok4uw	5886	4	-	-	HYPH
cord-001835-0s7ok4uw	5886	5	Level	level	NN
cord-001835-0s7ok4uw	5886	6	Iterative	iterative	JJ
cord-001835-0s7ok4uw	5886	7	clustering	clustering	NN
cord-001835-0s7ok4uw	5886	8	Process	process	NN
cord-001835-0s7ok4uw	5886	9	)	)	-RRB-
cord-001835-0s7ok4uw	5886	10	,	,	,
cord-001835-0s7ok4uw	5886	11	a	a	DT
cord-001835-0s7ok4uw	5886	12	process	process	NN
cord-001835-0s7ok4uw	5886	13	that	that	WDT
cord-001835-0s7ok4uw	5886	14	utilizes	utilize	VBZ
cord-001835-0s7ok4uw	5886	15	structural	structural	JJ
cord-001835-0s7ok4uw	5886	16	information	information	NN
cord-001835-0s7ok4uw	5886	17	from	from	IN
cord-001835-0s7ok4uw	5886	18	active	active	JJ
cord-001835-0s7ok4uw	5886	19	sites	site	NNS
cord-001835-0s7ok4uw	5886	20	to	to	TO
cord-001835-0s7ok4uw	5886	21	cluster	cluster	VB
cord-001835-0s7ok4uw	5886	22	protein	protein	NN
cord-001835-0s7ok4uw	5886	23	structures	structure	NNS
cord-001835-0s7ok4uw	5886	24	into	into	IN
cord-001835-0s7ok4uw	5886	25	hypothesized	hypothesize	VBN
cord-001835-0s7ok4uw	5886	26	functional	functional	JJ
cord-001835-0s7ok4uw	5886	27	groupings	grouping	NNS
cord-001835-0s7ok4uw	5886	28	,	,	,
cord-001835-0s7ok4uw	5886	29	and	and	CC
cord-001835-0s7ok4uw	5886	30	MISST	MISST	NNP
cord-001835-0s7ok4uw	5886	31	(	(	-LRB-
cord-001835-0s7ok4uw	5886	32	Multi	multi	JJ
cord-001835-0s7ok4uw	5886	33	-	-	JJ
cord-001835-0s7ok4uw	5886	34	level	level	JJ
cord-001835-0s7ok4uw	5886	35	Iterative	iterative	JJ
cord-001835-0s7ok4uw	5886	36	Sequence	sequence	NN
cord-001835-0s7ok4uw	5886	37	Searching	Searching	NNP
cord-001835-0s7ok4uw	5886	38	Technique	Technique	NNP
cord-001835-0s7ok4uw	5886	39	)	)	-RRB-
cord-001835-0s7ok4uw	5886	40	,	,	,
cord-001835-0s7ok4uw	5886	41	a	a	DT
cord-001835-0s7ok4uw	5886	42	process	process	NN
cord-001835-0s7ok4uw	5886	43	that	that	WDT
cord-001835-0s7ok4uw	5886	44	uses	use	VBZ
cord-001835-0s7ok4uw	5886	45	the	the	DT
cord-001835-0s7ok4uw	5886	46	protein	protein	NN
cord-001835-0s7ok4uw	5886	47	groupings	grouping	NNS
cord-001835-0s7ok4uw	5886	48	created	create	VBN
cord-001835-0s7ok4uw	5886	49	in	in	IN
cord-001835-0s7ok4uw	5886	50	TuLIP	TuLIP	NNP
cord-001835-0s7ok4uw	5886	51	as	as	IN
cord-001835-0s7ok4uw	5886	52	a	a	DT
cord-001835-0s7ok4uw	5886	53	starting	starting	NN
cord-001835-0s7ok4uw	5886	54	point	point	NN
cord-001835-0s7ok4uw	5886	55	for	for	IN
cord-001835-0s7ok4uw	5886	56	iterative	iterative	JJ
cord-001835-0s7ok4uw	5886	57	GenBank	GenBank	NNP
cord-001835-0s7ok4uw	5886	58	searches	search	NNS
cord-001835-0s7ok4uw	5886	59	and	and	CC
cord-001835-0s7ok4uw	5886	60	further	further	JJ
cord-001835-0s7ok4uw	5886	61	clustering	clustering	NN
cord-001835-0s7ok4uw	5886	62	after	after	IN
cord-001835-0s7ok4uw	5886	63	each	each	DT
cord-001835-0s7ok4uw	5886	64	search	search	NN
cord-001835-0s7ok4uw	5886	65	.	.	.
cord-001835-0s7ok4uw	5887	1	Through	through	IN
cord-001835-0s7ok4uw	5887	2	these	these	DT
cord-001835-0s7ok4uw	5887	3	two	two	CD
cord-001835-0s7ok4uw	5887	4	methods	method	NNS
cord-001835-0s7ok4uw	5887	5	,	,	,
cord-001835-0s7ok4uw	5887	6	the	the	DT
cord-001835-0s7ok4uw	5887	7	total	total	JJ
cord-001835-0s7ok4uw	5887	8	coverage	coverage	NN
cord-001835-0s7ok4uw	5887	9	of	of	IN
cord-001835-0s7ok4uw	5887	10	the	the	DT
cord-001835-0s7ok4uw	5887	11	Crotonase	Crotonase	NNP
cord-001835-0s7ok4uw	5887	12	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5887	13	has	have	VBZ
cord-001835-0s7ok4uw	5887	14	increased	increase	VBN
cord-001835-0s7ok4uw	5887	15	,	,	,
cord-001835-0s7ok4uw	5887	16	and	and	CC
cord-001835-0s7ok4uw	5887	17	the	the	DT
cord-001835-0s7ok4uw	5887	18	generated	generate	VBN
cord-001835-0s7ok4uw	5887	19	groups	group	NNS
cord-001835-0s7ok4uw	5887	20	contain	contain	VBP
cord-001835-0s7ok4uw	5887	21	proteins	protein	NNS
cord-001835-0s7ok4uw	5887	22	from	from	IN
cord-001835-0s7ok4uw	5887	23	subgroups	subgroup	NNS
cord-001835-0s7ok4uw	5887	24	and	and	CC
cord-001835-0s7ok4uw	5887	25	families	family	NNS
cord-001835-0s7ok4uw	5887	26	that	that	WDT
cord-001835-0s7ok4uw	5887	27	did	do	VBD
cord-001835-0s7ok4uw	5887	28	not	not	RB
cord-001835-0s7ok4uw	5887	29	have	have	VB
cord-001835-0s7ok4uw	5887	30	a	a	DT
cord-001835-0s7ok4uw	5887	31	structural	structural	JJ
cord-001835-0s7ok4uw	5887	32	representative	representative	NN
cord-001835-0s7ok4uw	5887	33	.	.	.
cord-001835-0s7ok4uw	5888	1	Novel	novel	NN
cord-001835-0s7ok4uw	5888	2	hypothesized	hypothesize	VBD
cord-001835-0s7ok4uw	5888	3	functional	functional	JJ
cord-001835-0s7ok4uw	5888	4	protein	protein	NN
cord-001835-0s7ok4uw	5888	5	groupings	grouping	NNS
cord-001835-0s7ok4uw	5888	6	have	have	VBP
cord-001835-0s7ok4uw	5888	7	been	be	VBN
cord-001835-0s7ok4uw	5888	8	created	create	VBN
cord-001835-0s7ok4uw	5888	9	,	,	,
cord-001835-0s7ok4uw	5888	10	most	most	RBS
cord-001835-0s7ok4uw	5888	11	notably	notably	RB
cord-001835-0s7ok4uw	5888	12	for	for	IN
cord-001835-0s7ok4uw	5888	13	a	a	DT
cord-001835-0s7ok4uw	5888	14	large	large	JJ
cord-001835-0s7ok4uw	5888	15	number	number	NN
cord-001835-0s7ok4uw	5888	16	of	of	IN
cord-001835-0s7ok4uw	5888	17	proteins	protein	NNS
cord-001835-0s7ok4uw	5888	18	that	that	WDT
cord-001835-0s7ok4uw	5888	19	lack	lack	VBP
cord-001835-0s7ok4uw	5888	20	annotation	annotation	NN
cord-001835-0s7ok4uw	5888	21	data	datum	NNS
cord-001835-0s7ok4uw	5888	22	at	at	IN
cord-001835-0s7ok4uw	5888	23	the	the	DT
cord-001835-0s7ok4uw	5888	24	subgroup	subgroup	NN
cord-001835-0s7ok4uw	5888	25	or	or	CC
cord-001835-0s7ok4uw	5888	26	family	family	NN
cord-001835-0s7ok4uw	5888	27	level	level	NN
cord-001835-0s7ok4uw	5888	28	,	,	,
cord-001835-0s7ok4uw	5888	29	and	and	CC
cord-001835-0s7ok4uw	5888	30	for	for	IN
cord-001835-0s7ok4uw	5888	31	proteins	protein	NNS
cord-001835-0s7ok4uw	5888	32	of	of	IN
cord-001835-0s7ok4uw	5888	33	the	the	DT
cord-001835-0s7ok4uw	5888	34	enoyl	enoyl	NNP
cord-001835-0s7ok4uw	5888	35	-	-	HYPH
cord-001835-0s7ok4uw	5888	36	CoA	CoA	NNP
cord-001835-0s7ok4uw	5888	37	hydratase	hydratase	NNP
cord-001835-0s7ok4uw	5888	38	family	family	NN
cord-001835-0s7ok4uw	5888	39	Fernandes	Fernandes	NNP
cord-001835-0s7ok4uw	5888	40	1	1	CD
cord-001835-0s7ok4uw	5888	41	,	,	,
cord-001835-0s7ok4uw	5888	42	Teresa	Teresa	NNP
cord-001835-0s7ok4uw	5888	43	Sorbo	Sorbo	NNP
cord-001835-0s7ok4uw	5888	44	2	2	CD
cord-001835-0s7ok4uw	5888	45	,	,	,
cord-001835-0s7ok4uw	5888	46	Ivan	Ivan	NNP
cord-001835-0s7ok4uw	5888	47	Duka	Duka	NNP
cord-001835-0s7ok4uw	5888	48	2	2	CD
cord-001835-0s7ok4uw	5888	49	,	,	,
cord-001835-0s7ok4uw	5888	50	Lia	Lia	NNP
cord-001835-0s7ok4uw	5888	51	Christina	Christina	NNP
cord-001835-0s7ok4uw	5888	52	Appold	Appold	NNP
cord-001835-0s7ok4uw	5888	53	3	3	CD
cord-001835-0s7ok4uw	5888	54	,	,	,
cord-001835-0s7ok4uw	5888	55	Marianne	Marianne	NNP
cord-001835-0s7ok4uw	5888	56	Ilbert	Ilbert	NNP
cord-001835-0s7ok4uw	5888	57	4	4	CD
cord-001835-0s7ok4uw	5888	58	,	,	,
cord-001835-0s7ok4uw	5888	59	Fabian	Fabian	NNP
cord-001835-0s7ok4uw	5888	60	Kiessling	Kiessling	NNP
cord-001835-0s7ok4uw	5888	61	3	3	CD
cord-001835-0s7ok4uw	5888	62	CNRS	CNRS	NNP
cord-001835-0s7ok4uw	5888	63	,	,	,
cord-001835-0s7ok4uw	5888	64	UMR	UMR	NNP
cord-001835-0s7ok4uw	5888	65	7281	7281	CD
cord-001835-0s7ok4uw	5888	66	,	,	,
cord-001835-0s7ok4uw	5888	67	5	5	CD
cord-001835-0s7ok4uw	5888	68	UCiBio	UCiBio	NNP
cord-001835-0s7ok4uw	5888	69	-	-	HYPH
cord-001835-0s7ok4uw	5888	70	REQUIMTE	REQUIMTE	NNP
cord-001835-0s7ok4uw	5888	71	,	,	,
cord-001835-0s7ok4uw	5888	72	Faculdade	Faculdade	NNP
cord-001835-0s7ok4uw	5888	73	de	de	NNP
cord-001835-0s7ok4uw	5888	74	Ciências	Ciências	NNP
cord-001835-0s7ok4uw	5888	75	e	e	NN
cord-001835-0s7ok4uw	5889	1	Tecnologia	Tecnologia	NNP
cord-001835-0s7ok4uw	5889	2	E	E	NNP
cord-001835-0s7ok4uw	5889	3	-	-	HYPH
cord-001835-0s7ok4uw	5889	4	selectin	selectin	NNP
cord-001835-0s7ok4uw	5889	5	is	be	VBZ
cord-001835-0s7ok4uw	5889	6	a	a	DT
cord-001835-0s7ok4uw	5889	7	cell	cell	NN
cord-001835-0s7ok4uw	5889	8	-	-	HYPH
cord-001835-0s7ok4uw	5889	9	adhesion	adhesion	NN
cord-001835-0s7ok4uw	5889	10	molecule	molecule	NN
cord-001835-0s7ok4uw	5889	11	induced	induce	VBN
cord-001835-0s7ok4uw	5889	12	on	on	IN
cord-001835-0s7ok4uw	5889	13	the	the	DT
cord-001835-0s7ok4uw	5889	14	surface	surface	NN
cord-001835-0s7ok4uw	5889	15	of	of	IN
cord-001835-0s7ok4uw	5889	16	endothelial	endothelial	JJ
cord-001835-0s7ok4uw	5889	17	cells	cell	NNS
cord-001835-0s7ok4uw	5889	18	in	in	IN
cord-001835-0s7ok4uw	5889	19	response	response	NN
cord-001835-0s7ok4uw	5889	20	to	to	IN
cord-001835-0s7ok4uw	5889	21	cytokines	cytokine	NNS
cord-001835-0s7ok4uw	5889	22	.	.	.
cord-001835-0s7ok4uw	5890	1	Its	-PRON-	PRP$
cord-001835-0s7ok4uw	5890	2	upregulation	upregulation	NN
cord-001835-0s7ok4uw	5890	3	has	have	VBZ
cord-001835-0s7ok4uw	5890	4	been	be	VBN
cord-001835-0s7ok4uw	5890	5	reported	report	VBN
cord-001835-0s7ok4uw	5890	6	in	in	IN
cord-001835-0s7ok4uw	5890	7	many	many	JJ
cord-001835-0s7ok4uw	5890	8	disorders	disorder	NNS
cord-001835-0s7ok4uw	5890	9	,	,	,
cord-001835-0s7ok4uw	5890	10	including	include	VBG
cord-001835-0s7ok4uw	5890	11	inflammatory	inflammatory	JJ
cord-001835-0s7ok4uw	5890	12	and	and	CC
cord-001835-0s7ok4uw	5890	13	cardiovascular	cardiovascular	JJ
cord-001835-0s7ok4uw	5890	14	diseases	disease	NNS
cord-001835-0s7ok4uw	5890	15	,	,	,
cord-001835-0s7ok4uw	5890	16	tumor	tumor	NN
cord-001835-0s7ok4uw	5890	17	angiogenesis	angiogenesis	NN
cord-001835-0s7ok4uw	5890	18	and	and	CC
cord-001835-0s7ok4uw	5890	19	metastasis	metastasis	NN
cord-001835-0s7ok4uw	5890	20	[	[	-LRB-
cord-001835-0s7ok4uw	5890	21	1	1	CD
cord-001835-0s7ok4uw	5890	22	]	]	-RRB-
cord-001835-0s7ok4uw	5890	23	.	.	.
cord-001835-0s7ok4uw	5891	1	This	this	DT
cord-001835-0s7ok4uw	5891	2	profile	profile	NN
cord-001835-0s7ok4uw	5891	3	suggests	suggest	VBZ
cord-001835-0s7ok4uw	5891	4	E	e	NN
cord-001835-0s7ok4uw	5891	5	-	-	NN
cord-001835-0s7ok4uw	5891	6	selectin	selectin	NNP
cord-001835-0s7ok4uw	5891	7	as	as	IN
cord-001835-0s7ok4uw	5891	8	a	a	DT
cord-001835-0s7ok4uw	5891	9	promising	promising	JJ
cord-001835-0s7ok4uw	5891	10	target	target	NN
cord-001835-0s7ok4uw	5891	11	to	to	TO
cord-001835-0s7ok4uw	5891	12	develop	develop	VB
cord-001835-0s7ok4uw	5891	13	molecular	molecular	JJ
cord-001835-0s7ok4uw	5891	14	imaging	imaging	NN
cord-001835-0s7ok4uw	5891	15	probes	probe	NNS
cord-001835-0s7ok4uw	5891	16	for	for	IN
cord-001835-0s7ok4uw	5891	17	the	the	DT
cord-001835-0s7ok4uw	5891	18	detection	detection	NN
cord-001835-0s7ok4uw	5891	19	of	of	IN
cord-001835-0s7ok4uw	5891	20	these	these	DT
cord-001835-0s7ok4uw	5891	21	diseases	disease	NNS
cord-001835-0s7ok4uw	5891	22	cyt	cyt	NNP
cord-001835-0s7ok4uw	5891	23	c	c	NN
cord-001835-0s7ok4uw	5891	24	with	with	IN
cord-001835-0s7ok4uw	5891	25	1	1	CD
cord-001835-0s7ok4uw	5891	26	equivalent	equivalent	NN
cord-001835-0s7ok4uw	5891	27	of	of	IN
cord-001835-0s7ok4uw	5891	28	fld	fld	NN
cord-001835-0s7ok4uw	5891	29	in	in	IN
cord-001835-0s7ok4uw	5891	30	media	medium	NNS
cord-001835-0s7ok4uw	5891	31	mimicking	mimic	VBG
cord-001835-0s7ok4uw	5891	32	the	the	DT
cord-001835-0s7ok4uw	5891	33	cytoplasm	cytoplasm	NN
cord-001835-0s7ok4uw	5891	34	.	.	.
cord-001835-0s7ok4uw	5892	1	These	these	DT
cord-001835-0s7ok4uw	5892	2	include	include	VBP
cord-001835-0s7ok4uw	5892	3	8	8	CD
cord-001835-0s7ok4uw	5892	4	%	%	NN
cord-001835-0s7ok4uw	5892	5	polyacrylamide	polyacrylamide	NN
cord-001835-0s7ok4uw	5892	6	gel	gel	NN
cord-001835-0s7ok4uw	5892	7	,	,	,
cord-001835-0s7ok4uw	5892	8	100	100	CD
cord-001835-0s7ok4uw	5892	9	g	g	NN
cord-001835-0s7ok4uw	5892	10	/	/	SYM
cord-001835-0s7ok4uw	5892	11	L	l	NN
cord-001835-0s7ok4uw	5892	12	bovine	bovine	JJ
cord-001835-0s7ok4uw	5892	13	serum	serum	NN
cord-001835-0s7ok4uw	5892	14	albumin	albumin	NN
cord-001835-0s7ok4uw	5892	15	or	or	CC
cord-001835-0s7ok4uw	5892	16	polyvinylpyrrolidone	polyvinylpyrrolidone	NN
cord-001835-0s7ok4uw	5892	17	40	40	CD
cord-001835-0s7ok4uw	5892	18	,	,	,
cord-001835-0s7ok4uw	5892	19	and	and	CC
cord-001835-0s7ok4uw	5892	20	buffer	buffer	VB
cord-001835-0s7ok4uw	5892	21	alone	alone	RB
cord-001835-0s7ok4uw	5892	22	for	for	IN
cord-001835-0s7ok4uw	5892	23	comparison	comparison	NN
cord-001835-0s7ok4uw	5892	24	.	.	.
cord-001835-0s7ok4uw	5893	1	Electrostatic	electrostatic	JJ
cord-001835-0s7ok4uw	5893	2	surface	surface	NN
cord-001835-0s7ok4uw	5893	3	representations	representation	NNS
cord-001835-0s7ok4uw	5893	4	of	of	IN
cord-001835-0s7ok4uw	5893	5	the	the	DT
cord-001835-0s7ok4uw	5893	6	proteins	protein	NNS
cord-001835-0s7ok4uw	5893	7	are	be	VBP
cord-001835-0s7ok4uw	5893	8	shown	show	VBN
cord-001835-0s7ok4uw	5893	9	with	with	IN
cord-001835-0s7ok4uw	5893	10	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5893	11	in	in	IN
cord-001835-0s7ok4uw	5893	12	-	-	HYPH
cord-001835-0s7ok4uw	5893	13	cell	cell	NN
cord-001835-0s7ok4uw	5893	14	spectrum	spectrum	NN
cord-001835-0s7ok4uw	5894	1	PL-060	pl-060	NN
cord-001835-0s7ok4uw	5895	1	A	a	DT
cord-001835-0s7ok4uw	5895	2	search	search	NN
cord-001835-0s7ok4uw	5895	3	for	for	IN
cord-001835-0s7ok4uw	5895	4	anti	anti	JJ
cord-001835-0s7ok4uw	5895	5	-	-	JJ
cord-001835-0s7ok4uw	5895	6	melioidosis	melioidosis	JJ
cord-001835-0s7ok4uw	5895	7	drug	drug	NN
cord-001835-0s7ok4uw	5895	8	candidates	candidate	NNS
cord-001835-0s7ok4uw	5895	9	targeted	target	VBN
cord-001835-0s7ok4uw	5895	10	to	to	IN
cord-001835-0s7ok4uw	5895	11	D	D	NNP
cord-001835-0s7ok4uw	5895	12	-	-	HYPH
cord-001835-0s7ok4uw	5895	13	glycero	glycero	NNP
cord-001835-0s7ok4uw	5896	1	-D	-D	:
cord-001835-0s7ok4uw	5896	2	-	-	HYPH
cord-001835-0s7ok4uw	5896	3	manno	manno	NNP
cord-001835-0s7ok4uw	5896	4	-	-	HYPH
cord-001835-0s7ok4uw	5896	5	heptose-1,7-bisphosphate	heptose-1,7-bisphosphate	NNP
cord-001835-0s7ok4uw	5897	1	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	5897	2	from	from	IN
cord-001835-0s7ok4uw	5897	3	Burkholderia	Burkholderia	NNP
cord-001835-0s7ok4uw	5897	4	pseudomallei	pseudomallei	NN
cord-001835-0s7ok4uw	5898	1	BpGmhB	BpGmhB	NNP
cord-001835-0s7ok4uw	5898	2	converts	convert	VBZ
cord-001835-0s7ok4uw	5898	3	Dglycero	Dglycero	NNP
cord-001835-0s7ok4uw	5898	4	-	-	HYPH
cord-001835-0s7ok4uw	5898	5	D	D	NNP
cord-001835-0s7ok4uw	5898	6	-	-	HYPH
cord-001835-0s7ok4uw	5898	7	manno	manno	NN
cord-001835-0s7ok4uw	5898	8	-	-	HYPH
cord-001835-0s7ok4uw	5898	9	heptose-1b,7-bisphosphate	heptose-1b,7-bisphosphate	JJ
cord-001835-0s7ok4uw	5898	10	to	to	IN
cord-001835-0s7ok4uw	5898	11	D	D	NNP
cord-001835-0s7ok4uw	5898	12	-	-	HYPH
cord-001835-0s7ok4uw	5898	13	glycero	glycero	NNP
cord-001835-0s7ok4uw	5898	14	-	-	HYPH
cord-001835-0s7ok4uw	5898	15	D	D	NNP
cord-001835-0s7ok4uw	5898	16	-	-	HYPH
cord-001835-0s7ok4uw	5898	17	manno	manno	NN
cord-001835-0s7ok4uw	5898	18	-	-	HYPH
cord-001835-0s7ok4uw	5898	19	heptose-1b	heptose-1b	NNP
cord-001835-0s7ok4uw	5898	20	-	-	HYPH
cord-001835-0s7ok4uw	5898	21	phosphate	phosphate	NN
cord-001835-0s7ok4uw	5898	22	.	.	.
cord-001835-0s7ok4uw	5899	1	This	this	DT
cord-001835-0s7ok4uw	5899	2	is	be	VBZ
cord-001835-0s7ok4uw	5899	3	the	the	DT
cord-001835-0s7ok4uw	5899	4	third	third	JJ
cord-001835-0s7ok4uw	5899	5	step	step	NN
cord-001835-0s7ok4uw	5899	6	of	of	IN
cord-001835-0s7ok4uw	5899	7	the	the	DT
cord-001835-0s7ok4uw	5899	8	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	5899	9	pathway	pathway	NN
cord-001835-0s7ok4uw	5899	10	of	of	IN
cord-001835-0s7ok4uw	5899	11	NDP	NDP	NNP
cord-001835-0s7ok4uw	5899	12	-	-	HYPH
cord-001835-0s7ok4uw	5899	13	heptose	heptose	NNP
cord-001835-0s7ok4uw	5899	14	responsible	responsible	JJ
cord-001835-0s7ok4uw	5899	15	for	for	IN
cord-001835-0s7ok4uw	5899	16	a	a	DT
cord-001835-0s7ok4uw	5899	17	pleiotropic	pleiotropic	JJ
cord-001835-0s7ok4uw	5899	18	phenotype	phenotype	NN
cord-001835-0s7ok4uw	5899	19	.	.	.
cord-001835-0s7ok4uw	5900	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	5900	2	,	,	,
cord-001835-0s7ok4uw	5900	3	this	this	DT
cord-001835-0s7ok4uw	5900	4	biosynthesis	biosynthesis	NN
cord-001835-0s7ok4uw	5900	5	pathway	pathway	NN
cord-001835-0s7ok4uw	5900	6	is	be	VBZ
cord-001835-0s7ok4uw	5900	7	the	the	DT
cord-001835-0s7ok4uw	5900	8	target	target	NN
cord-001835-0s7ok4uw	5900	9	for	for	IN
cord-001835-0s7ok4uw	5900	10	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	5900	11	increasing	increase	VBG
cord-001835-0s7ok4uw	5900	12	the	the	DT
cord-001835-0s7ok4uw	5900	13	membrane	membrane	NN
cord-001835-0s7ok4uw	5900	14	permeability	permeability	NN
cord-001835-0s7ok4uw	5900	15	of	of	IN
cord-001835-0s7ok4uw	5900	16	Gram	gram	NN
cord-001835-0s7ok4uw	5900	17	-	-	HYPH
cord-001835-0s7ok4uw	5900	18	negative	negative	JJ
cord-001835-0s7ok4uw	5900	19	pathogens	pathogen	NNS
cord-001835-0s7ok4uw	5900	20	or	or	CC
cord-001835-0s7ok4uw	5900	21	adjuvants	adjuvant	NNS
cord-001835-0s7ok4uw	5900	22	synergistically	synergistically	RB
cord-001835-0s7ok4uw	5900	23	working	work	VBG
cord-001835-0s7ok4uw	5900	24	with	with	IN
cord-001835-0s7ok4uw	5900	25	known	know	VBN
cord-001835-0s7ok4uw	5900	26	antibiotics	antibiotic	NNS
cord-001835-0s7ok4uw	5900	27	.	.	.
cord-001835-0s7ok4uw	5901	1	To	to	TO
cord-001835-0s7ok4uw	5901	2	find	find	VB
cord-001835-0s7ok4uw	5901	3	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	5901	4	of	of	IN
cord-001835-0s7ok4uw	5901	5	BpGmhB	BpGmhB	NNP
cord-001835-0s7ok4uw	5901	6	,	,	,
cord-001835-0s7ok4uw	5901	7	we	-PRON-	PRP
cord-001835-0s7ok4uw	5901	8	performed	perform	VBD
cord-001835-0s7ok4uw	5901	9	homology	homology	NN
cord-001835-0s7ok4uw	5901	10	modeling	modeling	NN
cord-001835-0s7ok4uw	5901	11	of	of	IN
cord-001835-0s7ok4uw	5901	12	BpGmhB	BpGmhB	NNP
cord-001835-0s7ok4uw	5901	13	and	and	CC
cord-001835-0s7ok4uw	5901	14	in	in	IN
cord-001835-0s7ok4uw	5901	15	-	-	HYPH
cord-001835-0s7ok4uw	5901	16	silico	silico	NN
cord-001835-0s7ok4uw	5901	17	virtual	virtual	JJ
cord-001835-0s7ok4uw	5901	18	screening	screening	NN
cord-001835-0s7ok4uw	5901	19	with	with	IN
cord-001835-0s7ok4uw	5901	20	ZINC	zinc	NN
cord-001835-0s7ok4uw	5901	21	,	,	,
cord-001835-0s7ok4uw	5901	22	a	a	DT
cord-001835-0s7ok4uw	5901	23	free	free	JJ
cord-001835-0s7ok4uw	5901	24	database	database	NN
cord-001835-0s7ok4uw	5901	25	of	of	IN
cord-001835-0s7ok4uw	5901	26	commerciallyavailable	commerciallyavailable	JJ
cord-001835-0s7ok4uw	5901	27	compounds	compound	NNS
cord-001835-0s7ok4uw	5901	28	.	.	.
cord-001835-0s7ok4uw	5902	1	Tens	ten	NNS
cord-001835-0s7ok4uw	5902	2	of	of	IN
cord-001835-0s7ok4uw	5902	3	thousands	thousand	NNS
cord-001835-0s7ok4uw	5902	4	of	of	IN
cord-001835-0s7ok4uw	5902	5	chemical	chemical	NN
cord-001835-0s7ok4uw	5902	6	compounds	compound	NNS
cord-001835-0s7ok4uw	5902	7	were	be	VBD
cord-001835-0s7ok4uw	5902	8	docked	dock	VBN
cord-001835-0s7ok4uw	5902	9	into	into	IN
cord-001835-0s7ok4uw	5902	10	the	the	DT
cord-001835-0s7ok4uw	5902	11	active	active	JJ
cord-001835-0s7ok4uw	5902	12	site	site	NN
cord-001835-0s7ok4uw	5902	13	of	of	IN
cord-001835-0s7ok4uw	5902	14	BpGmhB.	BpGmhB.	NNP
cord-001835-0s7ok4uw	5903	1	A	a	DT
cord-001835-0s7ok4uw	5903	2	number	number	NN
cord-001835-0s7ok4uw	5903	3	of	of	IN
cord-001835-0s7ok4uw	5903	4	putative	putative	JJ
cord-001835-0s7ok4uw	5903	5	BpGmhB	BpGmhB	NNP
cord-001835-0s7ok4uw	5903	6	binding	bind	VBG
cord-001835-0s7ok4uw	5903	7	compounds	compound	NNS
cord-001835-0s7ok4uw	5903	8	better	well	JJR
cord-001835-0s7ok4uw	5903	9	than	than	IN
cord-001835-0s7ok4uw	5903	10	D-	d-	XX
cord-001835-0s7ok4uw	5904	1	glycero	glycero	NNP
cord-001835-0s7ok4uw	5904	2	-	-	HYPH
cord-001835-0s7ok4uw	5904	3	D	D	NNP
cord-001835-0s7ok4uw	5904	4	-	-	HYPH
cord-001835-0s7ok4uw	5904	5	manno	manno	NN
cord-001835-0s7ok4uw	5904	6	-	-	HYPH
cord-001835-0s7ok4uw	5904	7	heptose-1b,7-bisphosphate	heptose-1b,7-bisphosphate	NNP
cord-001835-0s7ok4uw	5904	8	were	be	VBD
cord-001835-0s7ok4uw	5904	9	found	find	VBN
cord-001835-0s7ok4uw	5904	10	using	use	VBG
cord-001835-0s7ok4uw	5904	11	Surflex	Surflex	NNP
cord-001835-0s7ok4uw	5904	12	-	-	HYPH
cord-001835-0s7ok4uw	5904	13	Dock	Dock	NNP
cord-001835-0s7ok4uw	5904	14	included	include	VBD
cord-001835-0s7ok4uw	5904	15	in	in	IN
cord-001835-0s7ok4uw	5904	16	the	the	DT
cord-001835-0s7ok4uw	5904	17	SYBYL	SYBYL	NNP
cord-001835-0s7ok4uw	5904	18	software	software	NN
cord-001835-0s7ok4uw	5904	19	package	package	NN
cord-001835-0s7ok4uw	5904	20	Crystal	Crystal	NNP
cord-001835-0s7ok4uw	5904	21	structure	structure	NN
cord-001835-0s7ok4uw	5904	22	of	of	IN
cord-001835-0s7ok4uw	5904	23	dimeric	dimeric	JJ
cord-001835-0s7ok4uw	5904	24	D	D	NNP
cord-001835-0s7ok4uw	5904	25	-	-	HYPH
cord-001835-0s7ok4uw	5904	26	glycero	glycero	NNP
cord-001835-0s7ok4uw	5904	27	-	-	HYPH
cord-001835-0s7ok4uw	5904	28	D	D	NNP
cord-001835-0s7ok4uw	5904	29	-	-	HYPH
cord-001835-0s7ok4uw	5904	30	manno	manno	NNP
cord-001835-0s7ok4uw	5904	31	-	-	HYPH
cord-001835-0s7ok4uw	5904	32	heptose-1,7-bisphosphate	heptose-1,7-bisphosphate	JJ
cord-001835-0s7ok4uw	5904	33	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	5904	34	from	from	IN
cord-001835-0s7ok4uw	5904	35	Burkholderia	Burkholderia	NNP
cord-001835-0s7ok4uw	5904	36	thailandensis	thailandensis	NN
cord-001835-0s7ok4uw	5904	37	Ewha	Ewha	NNP
cord-001835-0s7ok4uw	5904	38	Womans	Womans	NNP
cord-001835-0s7ok4uw	5904	39	University	University	NNP
cord-001835-0s7ok4uw	5905	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5905	2	have	have	VBP
cord-001835-0s7ok4uw	5905	3	solved	solve	VBN
cord-001835-0s7ok4uw	5905	4	the	the	DT
cord-001835-0s7ok4uw	5905	5	crystal	crystal	NN
cord-001835-0s7ok4uw	5905	6	structures	structure	NNS
cord-001835-0s7ok4uw	5905	7	of	of	IN
cord-001835-0s7ok4uw	5905	8	D	D	NNP
cord-001835-0s7ok4uw	5905	9	-	-	HYPH
cord-001835-0s7ok4uw	5905	10	glycero	glycero	NNP
cord-001835-0s7ok4uw	5905	11	-	-	HYPH
cord-001835-0s7ok4uw	5905	12	D	D	NNP
cord-001835-0s7ok4uw	5905	13	-	-	HYPH
cord-001835-0s7ok4uw	5905	14	manno	manno	NNP
cord-001835-0s7ok4uw	5905	15	-	-	HYPH
cord-001835-0s7ok4uw	5905	16	heptose-1,7-bisphosphate	heptose-1,7-bisphosphate	JJ
cord-001835-0s7ok4uw	5905	17	phosphatase	phosphatase	NN
cord-001835-0s7ok4uw	5905	18	from	from	IN
cord-001835-0s7ok4uw	5905	19	Burkholderia	Burkholderia	NNP
cord-001835-0s7ok4uw	5905	20	thailandensis	thailandensis	NN
cord-001835-0s7ok4uw	5905	21	(	(	-LRB-
cord-001835-0s7ok4uw	5905	22	BtGmhB	BtGmhB	NNP
cord-001835-0s7ok4uw	5905	23	)	)	-RRB-
cord-001835-0s7ok4uw	5905	24	catalyzing	catalyze	VBG
cord-001835-0s7ok4uw	5905	25	the	the	DT
cord-001835-0s7ok4uw	5905	26	removal	removal	NN
cord-001835-0s7ok4uw	5905	27	of	of	IN
cord-001835-0s7ok4uw	5905	28	the	the	DT
cord-001835-0s7ok4uw	5905	29	phosphate	phosphate	NN
cord-001835-0s7ok4uw	5905	30	at	at	IN
cord-001835-0s7ok4uw	5905	31	the	the	DT
cord-001835-0s7ok4uw	5905	32	7	7	CD
cord-001835-0s7ok4uw	5905	33	position	position	NN
cord-001835-0s7ok4uw	5905	34	of	of	IN
cord-001835-0s7ok4uw	5905	35	D	D	NNP
cord-001835-0s7ok4uw	5905	36	-	-	HYPH
cord-001835-0s7ok4uw	5905	37	glycero	glycero	NNP
cord-001835-0s7ok4uw	5905	38	-	-	HYPH
cord-001835-0s7ok4uw	5905	39	D	D	NNP
cord-001835-0s7ok4uw	5905	40	-	-	HYPH
cord-001835-0s7ok4uw	5905	41	manno	manno	NNP
cord-001835-0s7ok4uw	5905	42	-	-	HYPH
cord-001835-0s7ok4uw	5905	43	heptose-1,7-bisphosphate	heptose-1,7-bisphosphate	NNP
cord-001835-0s7ok4uw	5905	44	.	.	.
cord-001835-0s7ok4uw	5906	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5906	2	belongs	belong	VBZ
cord-001835-0s7ok4uw	5906	3	to	to	IN
cord-001835-0s7ok4uw	5906	4	the	the	DT
cord-001835-0s7ok4uw	5906	5	haloacid	haloacid	NNP
cord-001835-0s7ok4uw	5906	6	dehalogenase	dehalogenase	NNP
cord-001835-0s7ok4uw	5906	7	(	(	-LRB-
cord-001835-0s7ok4uw	5906	8	HAD	have	VBD
cord-001835-0s7ok4uw	5906	9	)	)	-RRB-
cord-001835-0s7ok4uw	5906	10	superfamily	superfamily	NN
cord-001835-0s7ok4uw	5906	11	with	with	IN
cord-001835-0s7ok4uw	5906	12	an	an	DT
cord-001835-0s7ok4uw	5906	13	a	a	NN
cord-001835-0s7ok4uw	5906	14	/	/	SYM
cord-001835-0s7ok4uw	5906	15	b	b	NN
cord-001835-0s7ok4uw	5906	16	Rossman	Rossman	NNP
cord-001835-0s7ok4uw	5906	17	fold	fold	NN
cord-001835-0s7ok4uw	5906	18	composed	compose	VBN
cord-001835-0s7ok4uw	5906	19	of	of	IN
cord-001835-0s7ok4uw	5906	20	six	six	CD
cord-001835-0s7ok4uw	5906	21	parallel	parallel	JJ
cord-001835-0s7ok4uw	5906	22	b	b	NN
cord-001835-0s7ok4uw	5906	23	-	-	HYPH
cord-001835-0s7ok4uw	5906	24	strands	strand	NNS
cord-001835-0s7ok4uw	5906	25	sandwiched	sandwich	VBN
cord-001835-0s7ok4uw	5906	26	between	between	IN
cord-001835-0s7ok4uw	5906	27	two	two	CD
cord-001835-0s7ok4uw	5906	28	sets	set	NNS
cord-001835-0s7ok4uw	5906	29	of	of	IN
cord-001835-0s7ok4uw	5906	30	three	three	CD
cord-001835-0s7ok4uw	5906	31	a	a	DT
cord-001835-0s7ok4uw	5906	32	-	-	:
cord-001835-0s7ok4uw	5906	33	helices	helix	NNS
cord-001835-0s7ok4uw	5907	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5907	2	reveals	reveal	VBZ
cord-001835-0s7ok4uw	5907	3	a	a	DT
cord-001835-0s7ok4uw	5907	4	conventional	conventional	JJ
cord-001835-0s7ok4uw	5907	5	Rossman	Rossman	NNP
cord-001835-0s7ok4uw	5907	6	-	-	HYPH
cord-001835-0s7ok4uw	5907	7	like	like	NNP
cord-001835-0s7ok4uw	5907	8	a	a	DT
cord-001835-0s7ok4uw	5907	9	-	-	HYPH
cord-001835-0s7ok4uw	5907	10	b	b	NN
cord-001835-0s7ok4uw	5907	11	-	-	:
cord-001835-0s7ok4uw	5907	12	a	a	DT
cord-001835-0s7ok4uw	5907	13	sandwich	sandwich	NN
cord-001835-0s7ok4uw	5907	14	fold	fold	VBG
cord-001835-0s7ok4uw	5907	15	with	with	IN
cord-001835-0s7ok4uw	5907	16	a	a	DT
cord-001835-0s7ok4uw	5907	17	novel	novel	NN
cord-001835-0s7ok4uw	5907	18	b	b	NN
cord-001835-0s7ok4uw	5907	19	-	-	HYPH
cord-001835-0s7ok4uw	5907	20	sheet	sheet	NN
cord-001835-0s7ok4uw	5907	21	topology	topology	NN
cord-001835-0s7ok4uw	5907	22	.	.	.
cord-001835-0s7ok4uw	5908	1	Its	-PRON-	PRP$
cord-001835-0s7ok4uw	5908	2	C	c	NN
cord-001835-0s7ok4uw	5908	3	-	-	HYPH
cord-001835-0s7ok4uw	5908	4	terminus	terminus	NN
cord-001835-0s7ok4uw	5908	5	is	be	VBZ
cord-001835-0s7ok4uw	5908	6	longer	long	JJR
cord-001835-0s7ok4uw	5908	7	than	than	IN
cord-001835-0s7ok4uw	5908	8	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5908	9	closest	close	JJS
cord-001835-0s7ok4uw	5908	10	relatives	relative	NNS
cord-001835-0s7ok4uw	5908	11	and	and	CC
cord-001835-0s7ok4uw	5908	12	forms	form	VBZ
cord-001835-0s7ok4uw	5908	13	an	an	DT
cord-001835-0s7ok4uw	5908	14	additional	additional	JJ
cord-001835-0s7ok4uw	5908	15	b	b	NN
cord-001835-0s7ok4uw	5908	16	-	-	HYPH
cord-001835-0s7ok4uw	5908	17	strand	strand	NN
cord-001835-0s7ok4uw	5908	18	whereas	whereas	IN
cord-001835-0s7ok4uw	5908	19	the	the	DT
cord-001835-0s7ok4uw	5908	20	shorter	short	JJR
cord-001835-0s7ok4uw	5908	21	C	c	NN
cord-001835-0s7ok4uw	5908	22	-	-	HYPH
cord-001835-0s7ok4uw	5908	23	terminus	terminus	NN
cord-001835-0s7ok4uw	5908	24	is	be	VBZ
cord-001835-0s7ok4uw	5908	25	random	random	JJ
cord-001835-0s7ok4uw	5908	26	coils	coil	NNS
cord-001835-0s7ok4uw	5908	27	in	in	IN
cord-001835-0s7ok4uw	5908	28	the	the	DT
cord-001835-0s7ok4uw	5908	29	relatives	relative	NNS
cord-001835-0s7ok4uw	5908	30	.	.	.
cord-001835-0s7ok4uw	5909	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	5909	2	,	,	,
cord-001835-0s7ok4uw	5909	3	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5909	4	core	core	NN
cord-001835-0s7ok4uw	5909	5	structure	structure	NN
cord-001835-0s7ok4uw	5909	6	is	be	VBZ
cord-001835-0s7ok4uw	5909	7	similar	similar	JJ
cord-001835-0s7ok4uw	5909	8	to	to	IN
cord-001835-0s7ok4uw	5909	9	that	that	DT
cord-001835-0s7ok4uw	5909	10	of	of	IN
cord-001835-0s7ok4uw	5909	11	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5909	12	IIB(cellobiose	iib(cellobiose	NN
cord-001835-0s7ok4uw	5909	13	)	)	-RRB-
cord-001835-0s7ok4uw	5909	14	from	from	IN
cord-001835-0s7ok4uw	5909	15	E.	E.	NNP
cord-001835-0s7ok4uw	5909	16	coli	coli	NNS
cord-001835-0s7ok4uw	5909	17	(	(	-LRB-
cord-001835-0s7ok4uw	5909	18	EcIIB(cel	EcIIB(cel	NNP
cord-001835-0s7ok4uw	5909	19	)	)	-RRB-
cord-001835-0s7ok4uw	5909	20	)	)	-RRB-
cord-001835-0s7ok4uw	5909	21	transferring	transfer	VBG
cord-001835-0s7ok4uw	5909	22	a	a	DT
cord-001835-0s7ok4uw	5909	23	phosphate	phosphate	NN
cord-001835-0s7ok4uw	5909	24	moiety	moiety	NN
cord-001835-0s7ok4uw	5909	25	.	.	.
cord-001835-0s7ok4uw	5910	1	In	in	IN
cord-001835-0s7ok4uw	5910	2	the	the	DT
cord-001835-0s7ok4uw	5910	3	active	active	JJ
cord-001835-0s7ok4uw	5910	4	site	site	NN
cord-001835-0s7ok4uw	5910	5	of	of	IN
cord-001835-0s7ok4uw	5910	6	the	the	DT
cord-001835-0s7ok4uw	5910	7	closest	close	JJS
cord-001835-0s7ok4uw	5910	8	EcEIIB(fruc	EcEIIB(fruc	NNP
cord-001835-0s7ok4uw	5910	9	)	)	-RRB-
cord-001835-0s7ok4uw	5910	10	homologues	homologue	NNS
cord-001835-0s7ok4uw	5910	11	,	,	,
cord-001835-0s7ok4uw	5910	12	a	a	DT
cord-001835-0s7ok4uw	5910	13	unique	unique	JJ
cord-001835-0s7ok4uw	5910	14	motif	motif	NN
cord-001835-0s7ok4uw	5910	15	CXXGXAHT	cxxgxaht	NN
cord-001835-0s7ok4uw	5910	16	comprising	comprise	VBG
cord-001835-0s7ok4uw	5910	17	a	a	DT
cord-001835-0s7ok4uw	5910	18	P	p	NN
cord-001835-0s7ok4uw	5910	19	-	-	HYPH
cord-001835-0s7ok4uw	5910	20	loop	loop	NN
cord-001835-0s7ok4uw	5910	21	like	like	IN
cord-001835-0s7ok4uw	5910	22	architecture	architecture	NN
cord-001835-0s7ok4uw	5910	23	including	include	VBG
cord-001835-0s7ok4uw	5910	24	a	a	DT
cord-001835-0s7ok4uw	5910	25	histidine	histidine	NN
cord-001835-0s7ok4uw	5910	26	residue	residue	NN
cord-001835-0s7ok4uw	5910	27	is	be	VBZ
cord-001835-0s7ok4uw	5910	28	found	find	VBN
cord-001835-0s7ok4uw	5910	29	.	.	.
cord-001835-0s7ok4uw	5911	1	The	the	DT
cord-001835-0s7ok4uw	5911	2	conserved	conserved	JJ
cord-001835-0s7ok4uw	5911	3	cysteine	cysteine	NN
cord-001835-0s7ok4uw	5911	4	on	on	IN
cord-001835-0s7ok4uw	5911	5	this	this	DT
cord-001835-0s7ok4uw	5911	6	loop	loop	NN
cord-001835-0s7ok4uw	5911	7	may	may	MD
cord-001835-0s7ok4uw	5911	8	be	be	VB
cord-001835-0s7ok4uw	5911	9	thiolated	thiolate	VBN
cord-001835-0s7ok4uw	5911	10	to	to	TO
cord-001835-0s7ok4uw	5911	11	act	act	VB
cord-001835-0s7ok4uw	5911	12	as	as	IN
cord-001835-0s7ok4uw	5911	13	a	a	DT
cord-001835-0s7ok4uw	5911	14	nucleophile	nucleophile	NN
cord-001835-0s7ok4uw	5911	15	similar	similar	JJ
cord-001835-0s7ok4uw	5911	16	to	to	IN
cord-001835-0s7ok4uw	5911	17	that	that	DT
cord-001835-0s7ok4uw	5911	18	of	of	IN
cord-001835-0s7ok4uw	5911	19	EcIIB(cel	EcIIB(cel	NNP
cord-001835-0s7ok4uw	5911	20	)	)	-RRB-
cord-001835-0s7ok4uw	5911	21	.	.	.
cord-001835-0s7ok4uw	5912	1	The	the	DT
cord-001835-0s7ok4uw	5912	2	conserved	conserved	JJ
cord-001835-0s7ok4uw	5912	3	histidine	histidine	NN
cord-001835-0s7ok4uw	5912	4	residue	residue	NN
cord-001835-0s7ok4uw	5912	5	is	be	VBZ
cord-001835-0s7ok4uw	5912	6	presumed	presume	VBN
cord-001835-0s7ok4uw	5912	7	to	to	TO
cord-001835-0s7ok4uw	5912	8	accommodate	accommodate	VB
cord-001835-0s7ok4uw	5912	9	negatively	negatively	RB
cord-001835-0s7ok4uw	5912	10	charged	charge	VBN
cord-001835-0s7ok4uw	5912	11	phosphate	phosphate	NN
cord-001835-0s7ok4uw	5912	12	during	during	IN
cord-001835-0s7ok4uw	5912	13	enzymatic	enzymatic	JJ
cord-001835-0s7ok4uw	5912	14	catalysis	catalysis	NN
cord-001835-0s7ok4uw	5912	15	Leonor	Leonor	NNP
cord-001835-0s7ok4uw	5912	16	Morgado	Morgado	NNP
cord-001835-0s7ok4uw	5912	17	1	1	CD
cord-001835-0s7ok4uw	5912	18	,	,	,
cord-001835-0s7ok4uw	5912	19	Kornelius	Kornelius	NNP
cord-001835-0s7ok4uw	5912	20	Zeth	Zeth	NNP
cord-001835-0s7ok4uw	5912	21	1,2,3	1,2,3	CD
cord-001835-0s7ok4uw	5912	22	,	,	,
cord-001835-0s7ok4uw	5912	23	Bj€	Bj€	NNP
cord-001835-0s7ok4uw	5912	24	orn	orn	NN
cord-001835-0s7ok4uw	5912	25	M.	M.	NNP
cord-001835-0s7ok4uw	5912	26	Burmann	Burmann	NNP
cord-001835-0s7ok4uw	5912	27	1	1	CD
cord-001835-0s7ok4uw	5912	28	,	,	,
cord-001835-0s7ok4uw	5912	29	Timm	Timm	NNP
cord-001835-0s7ok4uw	5912	30	Maier	Maier	NNP
cord-001835-0s7ok4uw	5912	31	1	1	CD
cord-001835-0s7ok4uw	5912	32	BamA	BamA	NNP
cord-001835-0s7ok4uw	5912	33	is	be	VBZ
cord-001835-0s7ok4uw	5912	34	a	a	DT
cord-001835-0s7ok4uw	5912	35	b	b	NN
cord-001835-0s7ok4uw	5912	36	-	-	HYPH
cord-001835-0s7ok4uw	5912	37	barrel	barrel	NN
cord-001835-0s7ok4uw	5912	38	membrane	membrane	NN
cord-001835-0s7ok4uw	5912	39	protein	protein	NN
cord-001835-0s7ok4uw	5912	40	with	with	IN
cord-001835-0s7ok4uw	5912	41	five	five	CD
cord-001835-0s7ok4uw	5912	42	periplasmic	periplasmic	JJ
cord-001835-0s7ok4uw	5912	43	N	n	CD
cord-001835-0s7ok4uw	5912	44	-	-	HYPH
cord-001835-0s7ok4uw	5912	45	terminal	terminal	NN
cord-001835-0s7ok4uw	5912	46	polypeptide	polypeptide	NN
cord-001835-0s7ok4uw	5912	47	transport	transport	NN
cord-001835-0s7ok4uw	5912	48	associated	associate	VBN
cord-001835-0s7ok4uw	5912	49	(	(	-LRB-
cord-001835-0s7ok4uw	5912	50	POTRA	POTRA	NNP
cord-001835-0s7ok4uw	5912	51	)	)	-RRB-
cord-001835-0s7ok4uw	5912	52	domains	domain	NNS
cord-001835-0s7ok4uw	5912	53	.	.	.
cord-001835-0s7ok4uw	5913	1	The	the	DT
cord-001835-0s7ok4uw	5913	2	BamA	BamA	NNP
cord-001835-0s7ok4uw	5913	3	structure	structure	NN
cord-001835-0s7ok4uw	5913	4	has	have	VBZ
cord-001835-0s7ok4uw	5913	5	been	be	VBN
cord-001835-0s7ok4uw	5913	6	determined	determine	VBN
cord-001835-0s7ok4uw	5913	7	recently	recently	RB
cord-001835-0s7ok4uw	5913	8	by	by	IN
cord-001835-0s7ok4uw	5913	9	X	x	NN
cord-001835-0s7ok4uw	5913	10	-	-	NN
cord-001835-0s7ok4uw	5913	11	ray	ray	NN
cord-001835-0s7ok4uw	5913	12	crystallography	crystallography	NN
cord-001835-0s7ok4uw	5913	13	(	(	-LRB-
cord-001835-0s7ok4uw	5913	14	2,3	2,3	CD
cord-001835-0s7ok4uw	5913	15	)	)	-RRB-
cord-001835-0s7ok4uw	5913	16	,	,	,
cord-001835-0s7ok4uw	5913	17	however	however	RB
cord-001835-0s7ok4uw	5913	18	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5913	19	functional	functional	JJ
cord-001835-0s7ok4uw	5913	20	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5913	21	is	be	VBZ
cord-001835-0s7ok4uw	5913	22	not	not	RB
cord-001835-0s7ok4uw	5913	23	well	well	RB
cord-001835-0s7ok4uw	5913	24	understood	understand	VBN
cord-001835-0s7ok4uw	5913	25	.	.	.
cord-001835-0s7ok4uw	5914	1	This	this	DT
cord-001835-0s7ok4uw	5914	2	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5914	3	comprises	comprise	VBZ
cord-001835-0s7ok4uw	5914	4	the	the	DT
cord-001835-0s7ok4uw	5914	5	insertion	insertion	NN
cord-001835-0s7ok4uw	5914	6	of	of	IN
cord-001835-0s7ok4uw	5914	7	substrates	substrate	NNS
cord-001835-0s7ok4uw	5914	8	from	from	IN
cord-001835-0s7ok4uw	5914	9	a	a	DT
cord-001835-0s7ok4uw	5914	10	dynamic	dynamic	JJ
cord-001835-0s7ok4uw	5914	11	,	,	,
cord-001835-0s7ok4uw	5914	12	chaperone	chaperone	NN
cord-001835-0s7ok4uw	5914	13	-	-	HYPH
cord-001835-0s7ok4uw	5914	14	bound	bind	VBN
cord-001835-0s7ok4uw	5914	15	state	state	NN
cord-001835-0s7ok4uw	5914	16	into	into	IN
cord-001835-0s7ok4uw	5914	17	the	the	DT
cord-001835-0s7ok4uw	5914	18	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5914	19	outer	outer	JJ
cord-001835-0s7ok4uw	5914	20	membrane	membrane	NN
cord-001835-0s7ok4uw	5914	21	,	,	,
cord-001835-0s7ok4uw	5914	22	and	and	CC
cord-001835-0s7ok4uw	5914	23	NMR	NMR	NNP
cord-001835-0s7ok4uw	5914	24	spectroscopy	spectroscopy	NN
cord-001835-0s7ok4uw	5914	25	is	be	VBZ
cord-001835-0s7ok4uw	5914	26	thus	thus	RB
cord-001835-0s7ok4uw	5914	27	a	a	DT
cord-001835-0s7ok4uw	5914	28	method	method	NN
cord-001835-0s7ok4uw	5914	29	of	of	IN
cord-001835-0s7ok4uw	5914	30	choice	choice	NN
cord-001835-0s7ok4uw	5914	31	for	for	IN
cord-001835-0s7ok4uw	5914	32	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5914	33	elucidation	elucidation	NN
cord-001835-0s7ok4uw	5914	34	We	-PRON-	PRP
cord-001835-0s7ok4uw	5914	35	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	5914	36	that	that	IN
cord-001835-0s7ok4uw	5914	37	knocked	knock	VBD
cord-001835-0s7ok4uw	5914	38	down	down	RP
cord-001835-0s7ok4uw	5914	39	autophagy	autophagy	NN
cord-001835-0s7ok4uw	5914	40	by	by	IN
cord-001835-0s7ok4uw	5914	41	shRNA	shrna	NN
cord-001835-0s7ok4uw	5914	42	(	(	-LRB-
cord-001835-0s7ok4uw	5914	43	shAtg5	shAtg5	NNS
cord-001835-0s7ok4uw	5914	44	,	,	,
cord-001835-0s7ok4uw	5914	45	shBECN1	shBECN1	NNS
cord-001835-0s7ok4uw	5914	46	,	,	,
cord-001835-0s7ok4uw	5914	47	and	and	CC
cord-001835-0s7ok4uw	5914	48	shAtg12	shatg12	LS
cord-001835-0s7ok4uw	5914	49	)	)	-RRB-
cord-001835-0s7ok4uw	5914	50	and	and	CC
cord-001835-0s7ok4uw	5914	51	chloroquine	chloroquine	NNP
cord-001835-0s7ok4uw	5914	52	(	(	-LRB-
cord-001835-0s7ok4uw	5914	53	CQ	CQ	NNP
cord-001835-0s7ok4uw	5914	54	)	)	-RRB-
cord-001835-0s7ok4uw	5914	55	could	could	MD
cord-001835-0s7ok4uw	5914	56	enhance	enhance	VB
cord-001835-0s7ok4uw	5914	57	high	high	JJ
cord-001835-0s7ok4uw	5914	58	dose	dose	NN
cord-001835-0s7ok4uw	5914	59	of	of	IN
cord-001835-0s7ok4uw	5914	60	UVB	uvb	NN
cord-001835-0s7ok4uw	5914	61	induced	induce	VBN
cord-001835-0s7ok4uw	5914	62	cell	cell	NN
cord-001835-0s7ok4uw	5914	63	death	death	NN
cord-001835-0s7ok4uw	5914	64	in	in	IN
cord-001835-0s7ok4uw	5914	65	ODC	ODC	NNP
cord-001835-0s7ok4uw	5914	66	overexpressing	overexpresse	VBG
cord-001835-0s7ok4uw	5914	67	HeLa	HeLa	NNP
cord-001835-0s7ok4uw	5914	68	and	and	CC
cord-001835-0s7ok4uw	5914	69	MCF-7	MCF-7	NNP
cord-001835-0s7ok4uw	5914	70	cells	cell	NNS
cord-001835-0s7ok4uw	5914	71	.	.	.
cord-001835-0s7ok4uw	5915	1	Here	here	RB
cord-001835-0s7ok4uw	5915	2	,	,	,
cord-001835-0s7ok4uw	5915	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	5915	4	also	also	RB
cord-001835-0s7ok4uw	5915	5	observed	observe	VBD
cord-001835-0s7ok4uw	5915	6	that	that	IN
cord-001835-0s7ok4uw	5915	7	knocked	knock	VBD
cord-001835-0s7ok4uw	5915	8	down	down	RP
cord-001835-0s7ok4uw	5915	9	ODC	ODC	NNP
cord-001835-0s7ok4uw	5915	10	in	in	IN
cord-001835-0s7ok4uw	5915	11	ODC	ODC	NNP
cord-001835-0s7ok4uw	5915	12	overexpressing	overexpresse	VBG
cord-001835-0s7ok4uw	5915	13	HeLa	HeLa	NNP
cord-001835-0s7ok4uw	5915	14	and	and	CC
cord-001835-0s7ok4uw	5915	15	MCF-7	MCF-7	NNP
cord-001835-0s7ok4uw	5915	16	cells	cell	NNS
cord-001835-0s7ok4uw	5915	17	inhibited	inhibit	VBD
cord-001835-0s7ok4uw	5915	18	autophagy	autophagy	NN
cord-001835-0s7ok4uw	5915	19	and	and	CC
cord-001835-0s7ok4uw	5915	20	enhanced	enhance	VBN
cord-001835-0s7ok4uw	5915	21	high	high	JJ
cord-001835-0s7ok4uw	5915	22	dose	dose	NN
cord-001835-0s7ok4uw	5915	23	of	of	IN
cord-001835-0s7ok4uw	5915	24	UVB	uvb	NN
cord-001835-0s7ok4uw	5915	25	radiation	radiation	NN
cord-001835-0s7ok4uw	5915	26	.	.	.
cord-001835-0s7ok4uw	5916	1	Because	because	IN
cord-001835-0s7ok4uw	5916	2	of	of	IN
cord-001835-0s7ok4uw	5916	3	Atg12	Atg12	NNP
cord-001835-0s7ok4uw	5916	4	can	can	MD
cord-001835-0s7ok4uw	5916	5	regulate	regulate	VB
cord-001835-0s7ok4uw	5916	6	cell	cell	NN
cord-001835-0s7ok4uw	5916	7	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	5916	8	and	and	CC
cord-001835-0s7ok4uw	5916	9	utophagy	utophagy	NN
cord-001835-0s7ok4uw	5916	10	.	.	.
cord-001835-0s7ok4uw	5917	1	Site	site	NN
cord-001835-0s7ok4uw	5917	2	directed	direct	VBN
cord-001835-0s7ok4uw	5917	3	mutagenesis	mutagenesis	NN
cord-001835-0s7ok4uw	5917	4	was	be	VBD
cord-001835-0s7ok4uw	5917	5	used	use	VBN
cord-001835-0s7ok4uw	5917	6	to	to	TO
cord-001835-0s7ok4uw	5917	7	mutant	mutant	VB
cord-001835-0s7ok4uw	5917	8	the	the	DT
cord-001835-0s7ok4uw	5917	9	amino	amino	NN
cord-001835-0s7ok4uw	5917	10	acid	acid	NN
cord-001835-0s7ok4uw	5917	11	which	which	WDT
cord-001835-0s7ok4uw	5917	12	can	can	MD
cord-001835-0s7ok4uw	5917	13	regulate	regulate	VB
cord-001835-0s7ok4uw	5917	14	cell	cell	NN
cord-001835-0s7ok4uw	5917	15	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	5917	16	and	and	CC
cord-001835-0s7ok4uw	5917	17	autophagy	autophagy	NN
cord-001835-0s7ok4uw	5917	18	on	on	IN
cord-001835-0s7ok4uw	5917	19	Atg12	Atg12	NNP
cord-001835-0s7ok4uw	5917	20	,	,	,
cord-001835-0s7ok4uw	5917	21	respectively	respectively	RB
cord-001835-0s7ok4uw	5917	22	in	in	IN
cord-001835-0s7ok4uw	5917	23	these	these	DT
cord-001835-0s7ok4uw	5917	24	two	two	CD
cord-001835-0s7ok4uw	5917	25	ODC	ODC	NNP
cord-001835-0s7ok4uw	5917	26	overexpressing	overexpressing	NN
cord-001835-0s7ok4uw	5917	27	cells	cell	NNS
cord-001835-0s7ok4uw	5917	28	.	.	.
cord-001835-0s7ok4uw	5918	1	According	accord	VBG
cord-001835-0s7ok4uw	5918	2	to	to	IN
cord-001835-0s7ok4uw	5918	3	the	the	DT
cord-001835-0s7ok4uw	5918	4	results	result	NNS
cord-001835-0s7ok4uw	5918	5	Fish	Fish	NNP
cord-001835-0s7ok4uw	5918	6	ß	ß	NN
cord-001835-0s7ok4uw	5918	7	-	-	HYPH
cord-001835-0s7ok4uw	5918	8	parvalbumin	parvalbumin	NNP
cord-001835-0s7ok4uw	5918	9	acquires	acquire	VBZ
cord-001835-0s7ok4uw	5918	10	allergenic	allergenic	JJ
cord-001835-0s7ok4uw	5918	11	properties	property	NNS
cord-001835-0s7ok4uw	5918	12	by	by	IN
cord-001835-0s7ok4uw	5918	13	amyloid	amyloid	NN
cord-001835-0s7ok4uw	5918	14	assembly	assembly	NN
cord-001835-0s7ok4uw	5918	15	Using	use	VBG
cord-001835-0s7ok4uw	5918	16	Atlantic	Atlantic	NNP
cord-001835-0s7ok4uw	5918	17	cod	cod	NN
cord-001835-0s7ok4uw	5918	18	b	b	NN
cord-001835-0s7ok4uw	5918	19	-	-	HYPH
cord-001835-0s7ok4uw	5918	20	parvalbumin	parvalbumin	NNP
cord-001835-0s7ok4uw	5918	21	(	(	-LRB-
cord-001835-0s7ok4uw	5918	22	rGad	rGad	NNP
cord-001835-0s7ok4uw	5918	23	m	m	NN
cord-001835-0s7ok4uw	5918	24	1	1	CD
cord-001835-0s7ok4uw	5918	25	)	)	-RRB-
cord-001835-0s7ok4uw	5919	1	displaying	display	VBG
cord-001835-0s7ok4uw	5919	2	high	high	JJ
cord-001835-0s7ok4uw	5919	3	IgE	IgE	NNP
cord-001835-0s7ok4uw	5919	4	crossreactivity	crossreactivity	NN
cord-001835-0s7ok4uw	5919	5	,	,	,
cord-001835-0s7ok4uw	5919	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	5919	7	have	have	VBP
cord-001835-0s7ok4uw	5919	8	found	find	VBN
cord-001835-0s7ok4uw	5919	9	that	that	DT
cord-001835-0s7ok4uw	5919	10	formation	formation	NN
cord-001835-0s7ok4uw	5919	11	of	of	IN
cord-001835-0s7ok4uw	5919	12	amyloid	amyloid	NN
cord-001835-0s7ok4uw	5919	13	fibers	fiber	NNS
cord-001835-0s7ok4uw	5919	14	under	under	IN
cord-001835-0s7ok4uw	5919	15	simulated	simulated	JJ
cord-001835-0s7ok4uw	5919	16	gastrointestinal	gastrointestinal	JJ
cord-001835-0s7ok4uw	5919	17	conditions	condition	NNS
cord-001835-0s7ok4uw	5919	18	accounts	account	NNS
cord-001835-0s7ok4uw	5919	19	for	for	IN
cord-001835-0s7ok4uw	5919	20	the	the	DT
cord-001835-0s7ok4uw	5919	21	resistance	resistance	NN
cord-001835-0s7ok4uw	5919	22	to	to	IN
cord-001835-0s7ok4uw	5919	23	acid	acid	NN
cord-001835-0s7ok4uw	5919	24	and	and	CC
cord-001835-0s7ok4uw	5919	25	neutral	neutral	JJ
cord-001835-0s7ok4uw	5919	26	proteases	protease	NNS
cord-001835-0s7ok4uw	5919	27	,	,	,
cord-001835-0s7ok4uw	5919	28	for	for	IN
cord-001835-0s7ok4uw	5919	29	the	the	DT
cord-001835-0s7ok4uw	5919	30	presence	presence	NN
cord-001835-0s7ok4uw	5919	31	of	of	IN
cord-001835-0s7ok4uw	5919	32	membrane	membrane	NN
cord-001835-0s7ok4uw	5919	33	active	active	JJ
cord-001835-0s7ok4uw	5919	34	species	specie	NNS
cord-001835-0s7ok4uw	5919	35	at	at	IN
cord-001835-0s7ok4uw	5919	36	gastrointestinal	gastrointestinal	JJ
cord-001835-0s7ok4uw	5919	37	relevant	relevant	JJ
cord-001835-0s7ok4uw	5919	38	conditions	condition	NNS
cord-001835-0s7ok4uw	5919	39	and	and	CC
cord-001835-0s7ok4uw	5919	40	for	for	IN
cord-001835-0s7ok4uw	5919	41	the	the	DT
cord-001835-0s7ok4uw	5919	42	IgE	IgE	NNP
cord-001835-0s7ok4uw	5919	43	-	-	HYPH
cord-001835-0s7ok4uw	5919	44	recognition	recognition	NN
cord-001835-0s7ok4uw	5919	45	in	in	IN
cord-001835-0s7ok4uw	5919	46	allergic	allergic	JJ
cord-001835-0s7ok4uw	5919	47	patient	patient	NN
cord-001835-0s7ok4uw	5919	48	sera	sera	NNP
cord-001835-0s7ok4uw	5919	49	.	.	.
cord-001835-0s7ok4uw	5920	1	Incorporation	incorporation	NN
cord-001835-0s7ok4uw	5920	2	of	of	IN
cord-001835-0s7ok4uw	5920	3	the	the	DT
cord-001835-0s7ok4uw	5920	4	anti	anti	JJ
cord-001835-0s7ok4uw	5920	5	-	-	JJ
cord-001835-0s7ok4uw	5920	6	amyloid	amyloid	JJ
cord-001835-0s7ok4uw	5920	7	compound	compound	NN
cord-001835-0s7ok4uw	5920	8	epigallocathequin	epigallocathequin	NN
cord-001835-0s7ok4uw	5920	9	gallate	gallate	NN
cord-001835-0s7ok4uw	5920	10	prevents	prevent	VBZ
cord-001835-0s7ok4uw	5920	11	rGad	rGad	NNP
cord-001835-0s7ok4uw	5920	12	m1	m1	NNP
cord-001835-0s7ok4uw	5920	13	fibrillation	fibrillation	NN
cord-001835-0s7ok4uw	5920	14	,	,	,
cord-001835-0s7ok4uw	5920	15	facilitates	facilitate	VBZ
cord-001835-0s7ok4uw	5920	16	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5920	17	protease	protease	NN
cord-001835-0s7ok4uw	5920	18	digestion	digestion	NN
cord-001835-0s7ok4uw	5920	19	and	and	CC
cord-001835-0s7ok4uw	5920	20	impairs	impair	VBZ
cord-001835-0s7ok4uw	5920	21	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5920	22	recognition	recognition	NN
cord-001835-0s7ok4uw	5920	23	by	by	IN
cord-001835-0s7ok4uw	5920	24	IgE.	ige.	NN
cord-001835-0s7ok4uw	5921	1	Conclusions	conclusion	NNS
cord-001835-0s7ok4uw	5921	2	:	:	:
cord-001835-0s7ok4uw	5921	3	rGad	rGad	NNP
cord-001835-0s7ok4uw	5921	4	m	m	NN
cord-001835-0s7ok4uw	5921	5	1	1	CD
cord-001835-0s7ok4uw	5921	6	amyloid	amyloid	NN
cord-001835-0s7ok4uw	5921	7	formation	formation	NN
cord-001835-0s7ok4uw	5921	8	explains	explain	VBZ
cord-001835-0s7ok4uw	5921	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5921	10	degradation	degradation	NN
cord-001835-0s7ok4uw	5921	11	resistance	resistance	NN
cord-001835-0s7ok4uw	5921	12	,	,	,
cord-001835-0s7ok4uw	5921	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5921	14	facilitated	facilitate	VBN
cord-001835-0s7ok4uw	5921	15	passage	passage	NN
cord-001835-0s7ok4uw	5921	16	across	across	IN
cord-001835-0s7ok4uw	5921	17	the	the	DT
cord-001835-0s7ok4uw	5921	18	intestinal	intestinal	JJ
cord-001835-0s7ok4uw	5921	19	epithelial	epithelial	JJ
cord-001835-0s7ok4uw	5921	20	barrier	barrier	NN
cord-001835-0s7ok4uw	5921	21	and	and	CC
cord-001835-0s7ok4uw	5921	22	the	the	DT
cord-001835-0s7ok4uw	5921	23	epitope	epitope	NN
cord-001835-0s7ok4uw	5921	24	architecture	architecture	NN
cord-001835-0s7ok4uw	5921	25	as	as	IN
cord-001835-0s7ok4uw	5921	26	allergen	allergen	NN
cord-001835-0s7ok4uw	5921	27	Autophagy	Autophagy	NNP
cord-001835-0s7ok4uw	5921	28	could	could	MD
cord-001835-0s7ok4uw	5921	29	degrade	degrade	VB
cord-001835-0s7ok4uw	5921	30	the	the	DT
cord-001835-0s7ok4uw	5921	31	citrullinated	citrullinate	VBN
cord-001835-0s7ok4uw	5921	32	and	and	CC
cord-001835-0s7ok4uw	5921	33	unfolding	unfold	VBG
cord-001835-0s7ok4uw	5921	34	protein	protein	NN
cord-001835-0s7ok4uw	5921	35	.	.	.
cord-001835-0s7ok4uw	5922	1	Herein	herein	RB
cord-001835-0s7ok4uw	5922	2	,	,	,
cord-001835-0s7ok4uw	5922	3	PADI2	PADI2	NNP
cord-001835-0s7ok4uw	5922	4	could	could	MD
cord-001835-0s7ok4uw	5922	5	enhance	enhance	VB
cord-001835-0s7ok4uw	5922	6	autophagy	autophagy	NN
cord-001835-0s7ok4uw	5922	7	in	in	IN
cord-001835-0s7ok4uw	5922	8	Jurkat	Jurkat	NNP
cord-001835-0s7ok4uw	5922	9	T	T	NNP
cord-001835-0s7ok4uw	5922	10	cells	cell	NNS
cord-001835-0s7ok4uw	5922	11	and	and	CC
cord-001835-0s7ok4uw	5922	12	lead	lead	VBP
cord-001835-0s7ok4uw	5922	13	to	to	IN
cord-001835-0s7ok4uw	5922	14	a	a	DT
cord-001835-0s7ok4uw	5922	15	degradation	degradation	NN
cord-001835-0s7ok4uw	5922	16	of	of	IN
cord-001835-0s7ok4uw	5922	17	p62	p62	NN
cord-001835-0s7ok4uw	5922	18	and	and	CC
cord-001835-0s7ok4uw	5922	19	the	the	DT
cord-001835-0s7ok4uw	5922	20	accumulation	accumulation	NN
cord-001835-0s7ok4uw	5922	21	of	of	IN
cord-001835-0s7ok4uw	5922	22	LC3-II	lc3-ii	NN
cord-001835-0s7ok4uw	5922	23	.	.	.
cord-001835-0s7ok4uw	5923	1	Autophagy	autophagy	UH
cord-001835-0s7ok4uw	5923	2	and	and	CC
cord-001835-0s7ok4uw	5923	3	apoptosis	apoptosis	NN
cord-001835-0s7ok4uw	5923	4	are	be	VBP
cord-001835-0s7ok4uw	5923	5	two	two	CD
cord-001835-0s7ok4uw	5923	6	critical	critical	JJ
cord-001835-0s7ok4uw	5923	7	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	5923	8	which	which	WDT
cord-001835-0s7ok4uw	5923	9	participate	participate	VBP
cord-001835-0s7ok4uw	5923	10	against	against	IN
cord-001835-0s7ok4uw	5923	11	cellular	cellular	JJ
cord-001835-0s7ok4uw	5923	12	stress	stress	NN
cord-001835-0s7ok4uw	5923	13	,	,	,
cord-001835-0s7ok4uw	5923	14	cell	cell	NN
cord-001835-0s7ok4uw	5923	15	activation	activation	NN
cord-001835-0s7ok4uw	5923	16	,	,	,
cord-001835-0s7ok4uw	5923	17	survival	survival	NN
cord-001835-0s7ok4uw	5923	18	and	and	CC
cord-001835-0s7ok4uw	5923	19	homeostasis	homeostasis	NN
cord-001835-0s7ok4uw	5923	20	.	.	.
cord-001835-0s7ok4uw	5924	1	PAD2-overexpressed	PAD2-overexpressed	NNP
cord-001835-0s7ok4uw	5924	2	Jurkat	Jurkat	NNP
cord-001835-0s7ok4uw	5924	3	T	T	NNP
cord-001835-0s7ok4uw	5924	4	cells	cell	NNS
cord-001835-0s7ok4uw	5924	5	caused	cause	VBD
cord-001835-0s7ok4uw	5924	6	the	the	DT
cord-001835-0s7ok4uw	5924	7	activation	activation	NN
cord-001835-0s7ok4uw	5924	8	of	of	IN
cord-001835-0s7ok4uw	5924	9	Th17	Th17	NNP
cord-001835-0s7ok4uw	5924	10	cells	cell	NNS
cord-001835-0s7ok4uw	5924	11	to	to	TO
cord-001835-0s7ok4uw	5924	12	increase	increase	VB
cord-001835-0s7ok4uw	5924	13	mRNA	mrna	NN
cord-001835-0s7ok4uw	5924	14	expression	expression	NN
cord-001835-0s7ok4uw	5924	15	of	of	IN
cord-001835-0s7ok4uw	5924	16	cytokines	cytokine	NNS
cord-001835-0s7ok4uw	5924	17	,	,	,
cord-001835-0s7ok4uw	5924	18	such	such	JJ
cord-001835-0s7ok4uw	5924	19	as	as	IN
cord-001835-0s7ok4uw	5924	20	IL-17	IL-17	NNP
cord-001835-0s7ok4uw	5924	21	,	,	,
cord-001835-0s7ok4uw	5924	22	IL-21	IL-21	NNP
cord-001835-0s7ok4uw	5924	23	,	,	,
cord-001835-0s7ok4uw	5924	24	IL-22	IL-22	NNP
cord-001835-0s7ok4uw	5924	25	and	and	CC
cord-001835-0s7ok4uw	5924	26	TNFa	TNFa	NNS
cord-001835-0s7ok4uw	5924	27	.	.	.
cord-001835-0s7ok4uw	5925	1	Cytokines	cytokine	NNS
cord-001835-0s7ok4uw	5925	2	provoked	provoke	VBD
cord-001835-0s7ok4uw	5925	3	caspase	caspase	JJ
cord-001835-0s7ok4uw	5925	4	expression	expression	NN
cord-001835-0s7ok4uw	5925	5	and	and	CC
cord-001835-0s7ok4uw	5925	6	led	lead	VBN
cord-001835-0s7ok4uw	5925	7	to	to	IN
cord-001835-0s7ok4uw	5925	8	caspase	caspase	NN
cord-001835-0s7ok4uw	5925	9	-	-	HYPH
cord-001835-0s7ok4uw	5925	10	mediated	mediate	VBN
cord-001835-0s7ok4uw	5925	11	cleavage	cleavage	NN
cord-001835-0s7ok4uw	5925	12	of	of	IN
cord-001835-0s7ok4uw	5925	13	Beclin-1	Beclin-1	NNP
cord-001835-0s7ok4uw	5925	14	which	which	WDT
cord-001835-0s7ok4uw	5925	15	was	be	VBD
cord-001835-0s7ok4uw	5925	16	an	an	DT
cord-001835-0s7ok4uw	5925	17	important	important	JJ
cord-001835-0s7ok4uw	5925	18	factor	factor	NN
cord-001835-0s7ok4uw	5925	19	of	of	IN
cord-001835-0s7ok4uw	5925	20	apoptotic	apoptotic	JJ
cord-001835-0s7ok4uw	5925	21	signaling	signaling	NN
cord-001835-0s7ok4uw	5925	22	.	.	.
cord-001835-0s7ok4uw	5926	1	Knockdown	knockdown	NN
cord-001835-0s7ok4uw	5926	2	of	of	IN
cord-001835-0s7ok4uw	5926	3	BCEN1	BCEN1	NNP
cord-001835-0s7ok4uw	5926	4	rescued	rescue	VBN
cord-001835-0s7ok4uw	5926	5	cell	cell	NN
cord-001835-0s7ok4uw	5926	6	survival	survival	NN
cord-001835-0s7ok4uw	5926	7	due	due	IN
cord-001835-0s7ok4uw	5926	8	to	to	IN
cord-001835-0s7ok4uw	5926	9	the	the	DT
cord-001835-0s7ok4uw	5926	10	increase	increase	NN
cord-001835-0s7ok4uw	5926	11	of	of	IN
cord-001835-0s7ok4uw	5926	12	Bcl	Bcl	NNP
cord-001835-0s7ok4uw	5926	13	-	-	HYPH
cord-001835-0s7ok4uw	5926	14	xL	xL	NNP
cord-001835-0s7ok4uw	5926	15	and	and	CC
cord-001835-0s7ok4uw	5926	16	the	the	DT
cord-001835-0s7ok4uw	5926	17	decrease	decrease	NN
cord-001835-0s7ok4uw	5926	18	of	of	IN
cord-001835-0s7ok4uw	5926	19	caspase-3	caspase-3	NNP
cord-001835-0s7ok4uw	5926	20	.	.	.
cord-001835-0s7ok4uw	5927	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5927	2	suggested	suggest	VBD
cord-001835-0s7ok4uw	5927	3	that	that	IN
cord-001835-0s7ok4uw	5927	4	PADI2	PADI2	NNP
cord-001835-0s7ok4uw	5927	5	participated	participate	VBN
cord-001835-0s7ok4uw	5927	6	in	in	IN
cord-001835-0s7ok4uw	5927	7	the	the	DT
cord-001835-0s7ok4uw	5927	8	activated	activate	VBN
cord-001835-0s7ok4uw	5927	9	T	T	NNP
cord-001835-0s7ok4uw	5927	10	cell	cell	NN
cord-001835-0s7ok4uw	5927	11	-	-	HYPH
cord-001835-0s7ok4uw	5927	12	induced	induce	VBN
cord-001835-0s7ok4uw	5927	13	autonomous	autonomous	JJ
cord-001835-0s7ok4uw	5927	14	death	death	NN
cord-001835-0s7ok4uw	5927	15	through	through	IN
cord-001835-0s7ok4uw	5927	16	triggering	trigger	VBG
cord-001835-0s7ok4uw	5927	17	ER	ER	NNP
cord-001835-0s7ok4uw	5927	18	stress	stress	NN
cord-001835-0s7ok4uw	5927	19	pathway	pathway	NN
cord-001835-0s7ok4uw	5927	20	Studies	study	NNS
cord-001835-0s7ok4uw	5927	21	on	on	IN
cord-001835-0s7ok4uw	5927	22	secondary	secondary	JJ
cord-001835-0s7ok4uw	5927	23	metabolites	metabolite	NNS
cord-001835-0s7ok4uw	5927	24	production	production	NN
cord-001835-0s7ok4uw	5927	25	and	and	CC
cord-001835-0s7ok4uw	5927	26	proteins	protein	NNS
cord-001835-0s7ok4uw	5927	27	and	and	CC
cord-001835-0s7ok4uw	5927	28	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	5927	29	of	of	IN
cord-001835-0s7ok4uw	5928	1	in	in	IN
cord-001835-0s7ok4uw	5928	2	vitro	vitro	FW
cord-001835-0s7ok4uw	5928	3	cultivated	cultivate	VBN
cord-001835-0s7ok4uw	5928	4	Artemisia	Artemisia	NNP
cord-001835-0s7ok4uw	5928	5	alba	alba	NNP
cord-001835-0s7ok4uw	5928	6	Turra	Turra	NNP
cord-001835-0s7ok4uw	5928	7	and	and	CC
cord-001835-0s7ok4uw	5928	8	relations	relation	NNS
cord-001835-0s7ok4uw	5928	9	with	with	IN
cord-001835-0s7ok4uw	5928	10	some	some	DT
cord-001835-0s7ok4uw	5928	11	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	5928	12	phytohormones	phytohormone	NNS
cord-001835-0s7ok4uw	5928	13	Yuliana	Yuliana	NNP
cord-001835-0s7ok4uw	5928	14	Raynova	Raynova	NNP
cord-001835-0s7ok4uw	5928	15	1	1	CD
cord-001835-0s7ok4uw	5928	16	,	,	,
cord-001835-0s7ok4uw	5928	17	Krassimira	Krassimira	NNP
cord-001835-0s7ok4uw	5928	18	Idakieva	Idakieva	NNP
cord-001835-0s7ok4uw	5928	19	1	1	CD
cord-001835-0s7ok4uw	5928	20	,	,	,
cord-001835-0s7ok4uw	5928	21	Vaclav	Vaclav	NNP
cord-001835-0s7ok4uw	5928	22	Motyka	Motyka	NNP
cord-001835-0s7ok4uw	5928	23	2	2	CD
cord-001835-0s7ok4uw	5928	24	,	,	,
cord-001835-0s7ok4uw	5928	25	Petre	Petre	NNP
cord-001835-0s7ok4uw	5928	26	Dobrev	Dobrev	NNP
cord-001835-0s7ok4uw	5928	27	2	2	CD
cord-001835-0s7ok4uw	5928	28	,	,	,
cord-001835-0s7ok4uw	5928	29	Yuliana	Yuliana	NNP
cord-001835-0s7ok4uw	5928	30	Markovska	Markovska	NNP
cord-001835-0s7ok4uw	5928	31	3	3	CD
cord-001835-0s7ok4uw	5928	32	,	,	,
cord-001835-0s7ok4uw	5928	33	Milka	Milka	NNP
cord-001835-0s7ok4uw	5928	34	Todorova	Todorova	NNP
cord-001835-0s7ok4uw	5928	35	1	1	CD
cord-001835-0s7ok4uw	5928	36	,	,	,
cord-001835-0s7ok4uw	5928	37	Antoaneta	Antoaneta	NNP
cord-001835-0s7ok4uw	5928	38	Trendafilova	Trendafilova	NNP
cord-001835-0s7ok4uw	5928	39	1	1	CD
cord-001835-0s7ok4uw	5928	40	,	,	,
cord-001835-0s7ok4uw	5929	1	Ljuba	Ljuba	NNP
cord-001835-0s7ok4uw	5929	2	Evstatieva	Evstatieva	NNP
cord-001835-0s7ok4uw	5929	3	4	4	CD
cord-001835-0s7ok4uw	5929	4	Switzerland	Switzerland	NNP
cord-001835-0s7ok4uw	5929	5	Aim	Aim	NNP
cord-001835-0s7ok4uw	5929	6	:	:	:
cord-001835-0s7ok4uw	5929	7	Artemisia	Artemisia	NNP
cord-001835-0s7ok4uw	5929	8	alba	alba	NNP
cord-001835-0s7ok4uw	5929	9	Turra	Turra	NNP
cord-001835-0s7ok4uw	5929	10	is	be	VBZ
cord-001835-0s7ok4uw	5929	11	an	an	DT
cord-001835-0s7ok4uw	5929	12	essential	essential	JJ
cord-001835-0s7ok4uw	5929	13	oil	oil	NN
cord-001835-0s7ok4uw	5929	14	bearing	bearing	NN
cord-001835-0s7ok4uw	5929	15	shrub	shrub	NN
cord-001835-0s7ok4uw	5929	16	,	,	,
cord-001835-0s7ok4uw	5929	17	characterized	characterize	VBN
cord-001835-0s7ok4uw	5929	18	with	with	IN
cord-001835-0s7ok4uw	5929	19	great	great	JJ
cord-001835-0s7ok4uw	5929	20	variability	variability	NN
cord-001835-0s7ok4uw	5929	21	of	of	IN
cord-001835-0s7ok4uw	5929	22	the	the	DT
cord-001835-0s7ok4uw	5929	23	essential	essential	JJ
cord-001835-0s7ok4uw	5929	24	oil	oil	NN
cord-001835-0s7ok4uw	5929	25	profile	profile	NN
cord-001835-0s7ok4uw	5929	26	of	of	IN
cord-001835-0s7ok4uw	5929	27	wild	wild	JJ
cord-001835-0s7ok4uw	5929	28	grown	grown	JJ
cord-001835-0s7ok4uw	5929	29	plants	plant	NNS
cord-001835-0s7ok4uw	5929	30	,	,	,
cord-001835-0s7ok4uw	5929	31	related	relate	VBN
cord-001835-0s7ok4uw	5929	32	to	to	IN
cord-001835-0s7ok4uw	5929	33	genetic	genetic	JJ
cord-001835-0s7ok4uw	5929	34	,	,	,
cord-001835-0s7ok4uw	5929	35	geographic	geographic	JJ
cord-001835-0s7ok4uw	5929	36	and	and	CC
cord-001835-0s7ok4uw	5929	37	environmental	environmental	JJ
cord-001835-0s7ok4uw	5929	38	factors	factor	NNS
cord-001835-0s7ok4uw	5929	39	.	.	.
cord-001835-0s7ok4uw	5930	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	5930	2	was	be	VBD
cord-001835-0s7ok4uw	5930	3	previously	previously	RB
cord-001835-0s7ok4uw	5930	4	established	establish	VBN
cord-001835-0s7ok4uw	5930	5	that	that	DT
cord-001835-0s7ok4uw	5930	6	inhibition	inhibition	NN
cord-001835-0s7ok4uw	5930	7	of	of	IN
cord-001835-0s7ok4uw	5930	8	rooting	root	VBG
cord-001835-0s7ok4uw	5930	9	in	in	IN
cord-001835-0s7ok4uw	5930	10	vitro	vitro	FW
cord-001835-0s7ok4uw	5930	11	caused	cause	VBN
cord-001835-0s7ok4uw	5930	12	by	by	IN
cord-001835-0s7ok4uw	5930	13	cytokinin	cytokinin	NNP
cord-001835-0s7ok4uw	5930	14	/	/	SYM
cord-001835-0s7ok4uw	5930	15	auxin	auxin	NN
cord-001835-0s7ok4uw	5930	16	treatment	treatment	NN
cord-001835-0s7ok4uw	5930	17	affected	affect	VBD
cord-001835-0s7ok4uw	5930	18	the	the	DT
cord-001835-0s7ok4uw	5930	19	essential	essential	JJ
cord-001835-0s7ok4uw	5930	20	oil	oil	NN
cord-001835-0s7ok4uw	5930	21	profile	profile	NN
cord-001835-0s7ok4uw	5930	22	of	of	IN
cord-001835-0s7ok4uw	5930	23	the	the	DT
cord-001835-0s7ok4uw	5930	24	plant	plant	NN
cord-001835-0s7ok4uw	5930	25	and	and	CC
cord-001835-0s7ok4uw	5930	26	these	these	DT
cord-001835-0s7ok4uw	5930	27	changes	change	NNS
cord-001835-0s7ok4uw	5930	28	were	be	VBD
cord-001835-0s7ok4uw	5930	29	also	also	RB
cord-001835-0s7ok4uw	5930	30	related	relate	VBN
cord-001835-0s7ok4uw	5930	31	to	to	IN
cord-001835-0s7ok4uw	5930	32	bioactive	bioactive	JJ
cord-001835-0s7ok4uw	5930	33	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	5930	34	cytokinin	cytokinin	NNP
cord-001835-0s7ok4uw	5930	35	levels	level	NNS
cord-001835-0s7ok4uw	5930	36	in	in	IN
cord-001835-0s7ok4uw	5930	37	vitro	vitro	FW
cord-001835-0s7ok4uw	5930	38	(	(	-LRB-
cord-001835-0s7ok4uw	5930	39	1	1	CD
cord-001835-0s7ok4uw	5930	40	,	,	,
cord-001835-0s7ok4uw	5930	41	2	2	CD
cord-001835-0s7ok4uw	5930	42	)	)	-RRB-
cord-001835-0s7ok4uw	5931	1	Cytokinin	Cytokinin	NNP
cord-001835-0s7ok4uw	5931	2	and	and	CC
cord-001835-0s7ok4uw	5931	3	auxin	auxin	NN
cord-001835-0s7ok4uw	5931	4	effect	effect	NN
cord-001835-0s7ok4uw	5931	5	on	on	IN
cord-001835-0s7ok4uw	5931	6	the	the	DT
cord-001835-0s7ok4uw	5931	7	terpenoid	terpenoid	NN
cord-001835-0s7ok4uw	5931	8	profile	profile	NN
cord-001835-0s7ok4uw	5931	9	of	of	IN
cord-001835-0s7ok4uw	5931	10	the	the	DT
cord-001835-0s7ok4uw	5931	11	essential	essential	JJ
cord-001835-0s7ok4uw	5931	12	oil	oil	NN
cord-001835-0s7ok4uw	5931	13	and	and	CC
cord-001835-0s7ok4uw	5931	14	morphological	morphological	JJ
cord-001835-0s7ok4uw	5931	15	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	5931	16	of	of	IN
cord-001835-0s7ok4uw	5931	17	shoot	shoot	NN
cord-001835-0s7ok4uw	5931	18	cultures	culture	NNS
cord-001835-0s7ok4uw	5931	19	of	of	IN
cord-001835-0s7ok4uw	5931	20	Artemisia	Artemisia	NNP
cord-001835-0s7ok4uw	5931	21	alba	alba	,
cord-001835-0s7ok4uw	5931	22	Terpenoid	Terpenoid	NNP
cord-001835-0s7ok4uw	5931	23	profile	profile	NN
cord-001835-0s7ok4uw	5931	24	of	of	IN
cord-001835-0s7ok4uw	5931	25	Artemisia	Artemisia	NNP
cord-001835-0s7ok4uw	5931	26	alba	alba	NNP
cord-001835-0s7ok4uw	5931	27	is	be	VBZ
cord-001835-0s7ok4uw	5931	28	related	relate	VBN
cord-001835-0s7ok4uw	5931	29	to	to	IN
cord-001835-0s7ok4uw	5931	30	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	5931	31	cytokinins	cytokinin	NNS
cord-001835-0s7ok4uw	5931	32	in	in	IN
cord-001835-0s7ok4uw	5931	33	vitro	vitro	FW
cord-001835-0s7ok4uw	5931	34	Salivary	salivary	NN
cord-001835-0s7ok4uw	5931	35	HNP	HNP	NNP
cord-001835-0s7ok4uw	5931	36	1	1	CD
cord-001835-0s7ok4uw	5932	1	-3	-3	NNP
cord-001835-0s7ok4uw	5932	2	are	be	VBP
cord-001835-0s7ok4uw	5932	3	conventionally	conventionally	RB
cord-001835-0s7ok4uw	5932	4	measured	measure	VBN
cord-001835-0s7ok4uw	5932	5	using	use	VBG
cord-001835-0s7ok4uw	5932	6	an	an	DT
cord-001835-0s7ok4uw	5932	7	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5932	8	-	-	HYPH
cord-001835-0s7ok4uw	5932	9	linked	link	VBN
cord-001835-0s7ok4uw	5932	10	immunosorbent	immunosorbent	JJ
cord-001835-0s7ok4uw	5932	11	assay	assay	NN
cord-001835-0s7ok4uw	5932	12	(	(	-LRB-
cord-001835-0s7ok4uw	5932	13	ELISA	ELISA	NNP
cord-001835-0s7ok4uw	5932	14	)	)	-RRB-
cord-001835-0s7ok4uw	5932	15	which	which	WDT
cord-001835-0s7ok4uw	5932	16	does	do	VBZ
cord-001835-0s7ok4uw	5932	17	not	not	RB
cord-001835-0s7ok4uw	5932	18	discriminate	discriminate	VB
cord-001835-0s7ok4uw	5932	19	between	between	IN
cord-001835-0s7ok4uw	5932	20	individual	individual	JJ
cord-001835-0s7ok4uw	5932	21	HNPs	hnp	NNS
cord-001835-0s7ok4uw	5932	22	due	due	IN
cord-001835-0s7ok4uw	5932	23	to	to	IN
cord-001835-0s7ok4uw	5932	24	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5932	25	structural	structural	JJ
cord-001835-0s7ok4uw	5932	26	similarities	similarity	NNS
cord-001835-0s7ok4uw	5932	27	.	.	.
cord-001835-0s7ok4uw	5933	1	Considering	consider	VBG
cord-001835-0s7ok4uw	5933	2	the	the	DT
cord-001835-0s7ok4uw	5933	3	biological	biological	JJ
cord-001835-0s7ok4uw	5933	4	importance	importance	NN
cord-001835-0s7ok4uw	5933	5	of	of	IN
cord-001835-0s7ok4uw	5933	6	salivary	salivary	JJ
cord-001835-0s7ok4uw	5933	7	human	human	JJ
cord-001835-0s7ok4uw	5933	8	neutrophil	neutrophil	NN
cord-001835-0s7ok4uw	5933	9	a	a	DT
cord-001835-0s7ok4uw	5933	10	-	-	HYPH
cord-001835-0s7ok4uw	5933	11	defensin	defensin	NN
cord-001835-0s7ok4uw	5933	12	(	(	-LRB-
cord-001835-0s7ok4uw	5933	13	HNPs	HNPs	NNP
cord-001835-0s7ok4uw	5933	14	)	)	-RRB-
cord-001835-0s7ok4uw	5933	15	,	,	,
cord-001835-0s7ok4uw	5933	16	there	there	EX
cord-001835-0s7ok4uw	5933	17	is	be	VBZ
cord-001835-0s7ok4uw	5933	18	therefore	therefore	RB
cord-001835-0s7ok4uw	5933	19	,	,	,
cord-001835-0s7ok4uw	5933	20	a	a	DT
cord-001835-0s7ok4uw	5933	21	need	need	NN
cord-001835-0s7ok4uw	5933	22	to	to	TO
cord-001835-0s7ok4uw	5933	23	develop	develop	VB
cord-001835-0s7ok4uw	5933	24	an	an	DT
cord-001835-0s7ok4uw	5933	25	analytical	analytical	JJ
cord-001835-0s7ok4uw	5933	26	method	method	NN
cord-001835-0s7ok4uw	5933	27	that	that	WDT
cord-001835-0s7ok4uw	5933	28	will	will	MD
cord-001835-0s7ok4uw	5933	29	discriminate	discriminate	VB
cord-001835-0s7ok4uw	5933	30	between	between	IN
cord-001835-0s7ok4uw	5933	31	the	the	DT
cord-001835-0s7ok4uw	5933	32	defensins	defensin	NNS
cord-001835-0s7ok4uw	5933	33	.	.	.
cord-001835-0s7ok4uw	5934	1	An	an	DT
cord-001835-0s7ok4uw	5934	2	LC	LC	NNP
cord-001835-0s7ok4uw	5934	3	-	-	HYPH
cord-001835-0s7ok4uw	5934	4	MS	MS	NNP
cord-001835-0s7ok4uw	5934	5	method	method	NN
cord-001835-0s7ok4uw	5934	6	has	have	VBZ
cord-001835-0s7ok4uw	5934	7	been	be	VBN
cord-001835-0s7ok4uw	5934	8	established	establish	VBN
cord-001835-0s7ok4uw	5934	9	for	for	IN
cord-001835-0s7ok4uw	5934	10	the	the	DT
cord-001835-0s7ok4uw	5934	11	separation	separation	NN
cord-001835-0s7ok4uw	5934	12	and	and	CC
cord-001835-0s7ok4uw	5934	13	detection	detection	NN
cord-001835-0s7ok4uw	5934	14	of	of	IN
cord-001835-0s7ok4uw	5934	15	HNP	HNP	NNP
cord-001835-0s7ok4uw	5934	16	1	1	CD
cord-001835-0s7ok4uw	5934	17	-	-	SYM
cord-001835-0s7ok4uw	5934	18	4	4	CD
cord-001835-0s7ok4uw	5934	19	.	.	.
cord-001835-0s7ok4uw	5935	1	The	the	DT
cord-001835-0s7ok4uw	5935	2	method	method	NN
cord-001835-0s7ok4uw	5935	3	has	have	VBZ
cord-001835-0s7ok4uw	5935	4	been	be	VBN
cord-001835-0s7ok4uw	5935	5	optimised	optimise	VBN
cord-001835-0s7ok4uw	5935	6	,	,	,
cord-001835-0s7ok4uw	5935	7	validated	validate	VBN
cord-001835-0s7ok4uw	5935	8	and	and	CC
cord-001835-0s7ok4uw	5935	9	applied	apply	VBN
cord-001835-0s7ok4uw	5935	10	to	to	TO
cord-001835-0s7ok4uw	5935	11	examine	examine	VB
cord-001835-0s7ok4uw	5935	12	the	the	DT
cord-001835-0s7ok4uw	5935	13	relative	relative	JJ
cord-001835-0s7ok4uw	5935	14	level	level	NN
cord-001835-0s7ok4uw	5935	15	of	of	IN
cord-001835-0s7ok4uw	5935	16	HNP	HNP	NNP
cord-001835-0s7ok4uw	5935	17	1	1	CD
cord-001835-0s7ok4uw	5935	18	-	-	SYM
cord-001835-0s7ok4uw	5935	19	4	4	CD
cord-001835-0s7ok4uw	5935	20	in	in	IN
cord-001835-0s7ok4uw	5935	21	participants	participant	NNS
cord-001835-0s7ok4uw	5935	22	undertaking	undertake	VBG
cord-001835-0s7ok4uw	5935	23	a	a	DT
cord-001835-0s7ok4uw	5935	24	circuit	circuit	NN
cord-001835-0s7ok4uw	5935	25	resistance	resistance	NN
cord-001835-0s7ok4uw	5935	26	training	training	NN
cord-001835-0s7ok4uw	5935	27	workout	workout	NN
cord-001835-0s7ok4uw	5935	28	.	.	.
cord-001835-0s7ok4uw	5936	1	To	to	IN
cord-001835-0s7ok4uw	5936	2	date	date	NN
cord-001835-0s7ok4uw	5936	3	,	,	,
cord-001835-0s7ok4uw	5936	4	no	no	DT
cord-001835-0s7ok4uw	5936	5	studies	study	NNS
cord-001835-0s7ok4uw	5936	6	have	have	VBP
cord-001835-0s7ok4uw	5936	7	systematically	systematically	RB
cord-001835-0s7ok4uw	5936	8	investigated	investigate	VBN
cord-001835-0s7ok4uw	5936	9	the	the	DT
cord-001835-0s7ok4uw	5936	10	effect	effect	NN
cord-001835-0s7ok4uw	5936	11	of	of	IN
cord-001835-0s7ok4uw	5936	12	acute	acute	JJ
cord-001835-0s7ok4uw	5936	13	(	(	-LRB-
cord-001835-0s7ok4uw	5936	14	min	min	NN
cord-001835-0s7ok4uw	5936	15	to	to	IN
cord-001835-0s7ok4uw	5936	16	hours	hour	NNS
cord-001835-0s7ok4uw	5936	17	)	)	-RRB-
cord-001835-0s7ok4uw	5936	18	and	and	CC
cord-001835-0s7ok4uw	5936	19	chronic	chronic	JJ
cord-001835-0s7ok4uw	5936	20	(	(	-LRB-
cord-001835-0s7ok4uw	5936	21	days	day	NNS
cord-001835-0s7ok4uw	5936	22	to	to	IN
cord-001835-0s7ok4uw	5936	23	weeks	week	NNS
cord-001835-0s7ok4uw	5936	24	)	)	-RRB-
cord-001835-0s7ok4uw	5936	25	change	change	NN
cord-001835-0s7ok4uw	5936	26	in	in	IN
cord-001835-0s7ok4uw	5936	27	salivary	salivary	JJ
cord-001835-0s7ok4uw	5936	28	adefensins	adefensins	NNP
cord-001835-0s7ok4uw	5936	29	family	family	NN
cord-001835-0s7ok4uw	5936	30	before	before	RB
cord-001835-0s7ok4uw	5936	31	and	and	CC
cord-001835-0s7ok4uw	5936	32	after	after	IN
cord-001835-0s7ok4uw	5936	33	exercise	exercise	NN
cord-001835-0s7ok4uw	5936	34	by	by	IN
cord-001835-0s7ok4uw	5936	35	LC	LC	NNP
cord-001835-0s7ok4uw	5936	36	-	-	HYPH
cord-001835-0s7ok4uw	5936	37	ESI	ESI	NNP
cord-001835-0s7ok4uw	5936	38	-	-	HYPH
cord-001835-0s7ok4uw	5936	39	MS	MS	NNP
cord-001835-0s7ok4uw	5936	40	Systems	Systems	NNPS
cord-001835-0s7ok4uw	5936	41	and	and	CC
cord-001835-0s7ok4uw	5936	42	Models	Models	NNPS
cord-001835-0s7ok4uw	5936	43	calorimetry	calorimetry	NN
cord-001835-0s7ok4uw	5936	44	showed	show	VBD
cord-001835-0s7ok4uw	5936	45	no	no	DT
cord-001835-0s7ok4uw	5936	46	difference	difference	NN
cord-001835-0s7ok4uw	5936	47	in	in	IN
cord-001835-0s7ok4uw	5936	48	dissociation	dissociation	NN
cord-001835-0s7ok4uw	5936	49	constants	constant	NNS
cord-001835-0s7ok4uw	5936	50	at	at	IN
cord-001835-0s7ok4uw	5936	51	these	these	DT
cord-001835-0s7ok4uw	5936	52	pH	pH	NNP
cord-001835-0s7ok4uw	5936	53	values	value	NNS
cord-001835-0s7ok4uw	5936	54	,	,	,
cord-001835-0s7ok4uw	5936	55	while	while	IN
cord-001835-0s7ok4uw	5936	56	the	the	DT
cord-001835-0s7ok4uw	5936	57	binding	bind	VBG
cord-001835-0s7ok4uw	5936	58	stoichiometry	stoichiometry	NN
cord-001835-0s7ok4uw	5936	59	is	be	VBZ
cord-001835-0s7ok4uw	5936	60	increased	increase	VBN
cord-001835-0s7ok4uw	5936	61	2.5	2.5	CD
cord-001835-0s7ok4uw	5936	62	fold	fold	NN
cord-001835-0s7ok4uw	5936	63	.	.	.
cord-001835-0s7ok4uw	5937	1	Furthermore	furthermore	RB
cord-001835-0s7ok4uw	5937	2	,	,	,
cord-001835-0s7ok4uw	5937	3	the	the	DT
cord-001835-0s7ok4uw	5937	4	binding	bind	VBG
cord-001835-0s7ok4uw	5937	5	stoichiometry	stoichiometry	NN
cord-001835-0s7ok4uw	5937	6	varied	vary	VBD
cord-001835-0s7ok4uw	5937	7	7	7	CD
cord-001835-0s7ok4uw	5937	8	fold	fold	NN
cord-001835-0s7ok4uw	5937	9	among	among	IN
cord-001835-0s7ok4uw	5937	10	the	the	DT
cord-001835-0s7ok4uw	5937	11	two	two	CD
cord-001835-0s7ok4uw	5937	12	alginates	alginate	NNS
cord-001835-0s7ok4uw	5937	13	corresponding	correspond	VBG
cord-001835-0s7ok4uw	5937	14	to	to	IN
cord-001835-0s7ok4uw	5937	15	their	-PRON-	PRP$
cord-001835-0s7ok4uw	5937	16	difference	difference	NN
cord-001835-0s7ok4uw	5937	17	in	in	IN
cord-001835-0s7ok4uw	5937	18	average	average	JJ
cord-001835-0s7ok4uw	5937	19	molecular	molecular	JJ
cord-001835-0s7ok4uw	5937	20	weight	weight	NN
cord-001835-0s7ok4uw	5937	21	and	and	CC
cord-001835-0s7ok4uw	5937	22	in	in	IN
cord-001835-0s7ok4uw	5937	23	addition	addition	NN
cord-001835-0s7ok4uw	5937	24	20	20	CD
cord-001835-0s7ok4uw	5937	25	fold	fold	VB
cord-001835-0s7ok4uw	5937	26	higher	higher	RBR
cord-001835-0s7ok4uw	5937	27	binding	bind	VBG
cord-001835-0s7ok4uw	5937	28	affinity	affinity	NN
cord-001835-0s7ok4uw	5937	29	was	be	VBD
cord-001835-0s7ok4uw	5937	30	found	find	VBN
cord-001835-0s7ok4uw	5937	31	with	with	IN
cord-001835-0s7ok4uw	5937	32	the	the	DT
cord-001835-0s7ok4uw	5937	33	high	high	JJ
cord-001835-0s7ok4uw	5937	34	as	as	IN
cord-001835-0s7ok4uw	5937	35	compared	compare	VBN
cord-001835-0s7ok4uw	5937	36	to	to	IN
cord-001835-0s7ok4uw	5937	37	the	the	DT
cord-001835-0s7ok4uw	5937	38	low	low	JJ
cord-001835-0s7ok4uw	5937	39	molecular	molecular	JJ
cord-001835-0s7ok4uw	5937	40	weight	weight	NN
cord-001835-0s7ok4uw	5937	41	alginate	alginate	NN
cord-001835-0s7ok4uw	5937	42	.	.	.
cord-001835-0s7ok4uw	5938	1	In	in	IN
cord-001835-0s7ok4uw	5938	2	conclusion	conclusion	NN
cord-001835-0s7ok4uw	5938	3	,	,	,
cord-001835-0s7ok4uw	5938	4	the	the	DT
cord-001835-0s7ok4uw	5938	5	binding	bind	VBG
cord-001835-0s7ok4uw	5938	6	stoichiometry	stoichiometry	NN
cord-001835-0s7ok4uw	5938	7	of	of	IN
cord-001835-0s7ok4uw	5938	8	b	b	NN
cord-001835-0s7ok4uw	5938	9	-	-	:
cord-001835-0s7ok4uw	5938	10	lactoglobulin	lactoglobulin	NN
cord-001835-0s7ok4uw	5938	11	with	with	IN
cord-001835-0s7ok4uw	5938	12	alginate	alginate	NN
cord-001835-0s7ok4uw	5938	13	increases	increase	NNS
cord-001835-0s7ok4uw	5938	14	by	by	IN
cord-001835-0s7ok4uw	5938	15	a	a	DT
cord-001835-0s7ok4uw	5938	16	factor	factor	NN
cord-001835-0s7ok4uw	5938	17	that	that	WDT
cord-001835-0s7ok4uw	5938	18	correlates	correlate	VBZ
cord-001835-0s7ok4uw	5938	19	to	to	IN
cord-001835-0s7ok4uw	5938	20	the	the	DT
cord-001835-0s7ok4uw	5938	21	average	average	JJ
cord-001835-0s7ok4uw	5938	22	molecular	molecular	JJ
cord-001835-0s7ok4uw	5938	23	weight	weight	NN
cord-001835-0s7ok4uw	5938	24	of	of	IN
cord-001835-0s7ok4uw	5938	25	the	the	DT
cord-001835-0s7ok4uw	5938	26	alginate	alginate	NN
cord-001835-0s7ok4uw	5938	27	and	and	CC
cord-001835-0s7ok4uw	5938	28	also	also	RB
cord-001835-0s7ok4uw	5938	29	a	a	DT
cord-001835-0s7ok4uw	5938	30	much	much	RB
cord-001835-0s7ok4uw	5938	31	higher	high	JJR
cord-001835-0s7ok4uw	5938	32	affinity	affinity	NN
cord-001835-0s7ok4uw	5938	33	was	be	VBD
cord-001835-0s7ok4uw	5938	34	found	find	VBN
cord-001835-0s7ok4uw	5938	35	for	for	IN
cord-001835-0s7ok4uw	5938	36	the	the	DT
cord-001835-0s7ok4uw	5938	37	high	high	JJ
cord-001835-0s7ok4uw	5938	38	molecular	molecular	JJ
cord-001835-0s7ok4uw	5938	39	weight	weight	NN
cord-001835-0s7ok4uw	5938	40	alginate	alginate	NN
cord-001835-0s7ok4uw	5938	41	.	.	.
cord-001835-0s7ok4uw	5939	1	Acknowledgements	acknowledgement	NNS
cord-001835-0s7ok4uw	5939	2	:	:	:
cord-001835-0s7ok4uw	5940	1	This	this	DT
cord-001835-0s7ok4uw	5940	2	work	work	NN
cord-001835-0s7ok4uw	5940	3	is	be	VBZ
cord-001835-0s7ok4uw	5940	4	supported	support	VBN
cord-001835-0s7ok4uw	5940	5	by	by	IN
cord-001835-0s7ok4uw	5940	6	the	the	DT
cord-001835-0s7ok4uw	5940	7	Danish	Danish	NNP
cord-001835-0s7ok4uw	5940	8	Council	Council	NNP
cord-001835-0s7ok4uw	5940	9	for	for	IN
cord-001835-0s7ok4uw	5940	10	The	the	DT
cord-001835-0s7ok4uw	5940	11	presence	presence	NN
cord-001835-0s7ok4uw	5940	12	of	of	IN
cord-001835-0s7ok4uw	5940	13	mucins	mucin	NNS
cord-001835-0s7ok4uw	5940	14	and	and	CC
cord-001835-0s7ok4uw	5940	15	other	other	JJ
cord-001835-0s7ok4uw	5940	16	high	high	JJ
cord-001835-0s7ok4uw	5940	17	molecular	molecular	JJ
cord-001835-0s7ok4uw	5940	18	weight	weight	NN
cord-001835-0s7ok4uw	5940	19	glycoproteins	glycoprotein	NNS
cord-001835-0s7ok4uw	5940	20	in	in	IN
cord-001835-0s7ok4uw	5940	21	saliva	saliva	NN
cord-001835-0s7ok4uw	5940	22	makes	make	VBZ
cord-001835-0s7ok4uw	5940	23	the	the	DT
cord-001835-0s7ok4uw	5940	24	direct	direct	JJ
cord-001835-0s7ok4uw	5940	25	analysis	analysis	NN
cord-001835-0s7ok4uw	5940	26	of	of	IN
cord-001835-0s7ok4uw	5940	27	defensins	defensins	NNP
cord-001835-0s7ok4uw	5940	28	difficult	difficult	JJ
cord-001835-0s7ok4uw	5940	29	.	.	.
cord-001835-0s7ok4uw	5941	1	The	the	DT
cord-001835-0s7ok4uw	5941	2	LC	LC	NNP
cord-001835-0s7ok4uw	5941	3	-	-	HYPH
cord-001835-0s7ok4uw	5941	4	MS	MS	NNP
cord-001835-0s7ok4uw	5941	5	method	method	NN
cord-001835-0s7ok4uw	5941	6	was	be	VBD
cord-001835-0s7ok4uw	5941	7	linear	linear	JJ
cord-001835-0s7ok4uw	5941	8	for	for	IN
cord-001835-0s7ok4uw	5941	9	concentrations	concentration	NNS
cord-001835-0s7ok4uw	5941	10	of	of	IN
cord-001835-0s7ok4uw	5941	11	HNP-2	HNP-2	NNP
cord-001835-0s7ok4uw	5941	12	between	between	IN
cord-001835-0s7ok4uw	5941	13	0.05	0.05	CD
cord-001835-0s7ok4uw	5941	14	and	and	CC
cord-001835-0s7ok4uw	5941	15	1	1	CD
cord-001835-0s7ok4uw	5941	16	ng	ng	NN
cord-001835-0s7ok4uw	5941	17	/	/	SYM
cord-001835-0s7ok4uw	5941	18	mL	ml	NN
cord-001835-0s7ok4uw	5942	1	(	(	-LRB-
cord-001835-0s7ok4uw	5942	2	R2	R2	NNP
cord-001835-0s7ok4uw	5942	3	5	5	CD
cord-001835-0s7ok4uw	5942	4	0.99	0.99	CD
cord-001835-0s7ok4uw	5942	5	)	)	-RRB-
cord-001835-0s7ok4uw	5942	6	with	with	IN
cord-001835-0s7ok4uw	5942	7	a	a	DT
cord-001835-0s7ok4uw	5942	8	LOD	lod	NN
cord-001835-0s7ok4uw	5942	9	of	of	IN
cord-001835-0s7ok4uw	5942	10	0.05	0.05	CD
cord-001835-0s7ok4uw	5942	11	ng	ng	NNP
cord-001835-0s7ok4uw	5942	12	/	/	SYM
cord-001835-0s7ok4uw	5942	13	mL.	mL.	NNP
cord-001835-0s7ok4uw	5942	14	Inter	Inter	NNP
cord-001835-0s7ok4uw	5942	15	and	and	CC
cord-001835-0s7ok4uw	5942	16	intra	intra	JJ
cord-001835-0s7ok4uw	5942	17	assay	assay	NN
cord-001835-0s7ok4uw	5942	18	precision	precision	NN
cord-001835-0s7ok4uw	5942	19	was	be	VBD
cord-001835-0s7ok4uw	5942	20	0.94	0.94	CD
cord-001835-0s7ok4uw	5942	21	-15	-15	CD
cord-001835-0s7ok4uw	5942	22	%	%	NN
cord-001835-0s7ok4uw	5942	23	,	,	,
cord-001835-0s7ok4uw	5942	24	respectively	respectively	RB
cord-001835-0s7ok4uw	5942	25	.	.	.
cord-001835-0s7ok4uw	5943	1	Saliva	saliva	NN
cord-001835-0s7ok4uw	5943	2	sample	sample	NN
cord-001835-0s7ok4uw	5943	3	were	be	VBD
cord-001835-0s7ok4uw	5943	4	clean	clean	JJ
cord-001835-0s7ok4uw	5943	5	up	up	RP
cord-001835-0s7ok4uw	5943	6	by	by	IN
cord-001835-0s7ok4uw	5943	7	solid	solid	JJ
cord-001835-0s7ok4uw	5943	8	phase	phase	NN
cord-001835-0s7ok4uw	5943	9	extraction	extraction	NN
cord-001835-0s7ok4uw	5943	10	(	(	-LRB-
cord-001835-0s7ok4uw	5943	11	SPE	SPE	NNP
cord-001835-0s7ok4uw	5943	12	)	)	-RRB-
cord-001835-0s7ok4uw	5943	13	and	and	CC
cord-001835-0s7ok4uw	5943	14	without	without	IN
cord-001835-0s7ok4uw	5943	15	-	-	HYPH
cord-001835-0s7ok4uw	5943	16	solid	solid	JJ
cord-001835-0s7ok4uw	5943	17	phase	phase	NN
cord-001835-0s7ok4uw	5943	18	extraction	extraction	NN
cord-001835-0s7ok4uw	5943	19	(	(	-LRB-
cord-001835-0s7ok4uw	5943	20	WSPE	WSPE	NNP
cord-001835-0s7ok4uw	5943	21	)	)	-RRB-
cord-001835-0s7ok4uw	5943	22	2.10	2.10	CD
cord-001835-0s7ok4uw	5943	23	mm	mm	NNP
cord-001835-0s7ok4uw	5943	24	internal	internal	JJ
cord-001835-0s7ok4uw	5943	25	diameter	diameter	NN
cord-001835-0s7ok4uw	5943	26	column	column	NN
cord-001835-0s7ok4uw	5943	27	in	in	IN
cord-001835-0s7ok4uw	5943	28	relation	relation	NN
cord-001835-0s7ok4uw	5943	29	to	to	IN
cord-001835-0s7ok4uw	5943	30	the	the	DT
cord-001835-0s7ok4uw	5943	31	method	method	NN
cord-001835-0s7ok4uw	5943	32	transfer	transfer	NN
cord-001835-0s7ok4uw	5943	33	.	.	.
cord-001835-0s7ok4uw	5944	1	During	during	IN
cord-001835-0s7ok4uw	5944	2	LC	LC	NNP
cord-001835-0s7ok4uw	5944	3	-	-	HYPH
cord-001835-0s7ok4uw	5944	4	MS	MS	NNP
cord-001835-0s7ok4uw	5944	5	optimisation	optimisation	NN
cord-001835-0s7ok4uw	5944	6	Genome	Genome	NNP
cord-001835-0s7ok4uw	5944	7	-	-	HYPH
cord-001835-0s7ok4uw	5944	8	Wide	wide	JJ
cord-001835-0s7ok4uw	5944	9	Docking	docking	NN
cord-001835-0s7ok4uw	5944	10	Database	database	NN
cord-001835-0s7ok4uw	5944	11	(	(	-LRB-
cord-001835-0s7ok4uw	5944	12	GWIDD	GWIDD	NNP
cord-001835-0s7ok4uw	5944	13	)	)	-RRB-
cord-001835-0s7ok4uw	5944	14	provides	provide	VBZ
cord-001835-0s7ok4uw	5944	15	the	the	DT
cord-001835-0s7ok4uw	5944	16	most	most	RBS
cord-001835-0s7ok4uw	5944	17	extensive	extensive	JJ
cord-001835-0s7ok4uw	5944	18	data	data	NN
cord-001835-0s7ok4uw	5944	19	repository	repository	NN
cord-001835-0s7ok4uw	5944	20	of	of	IN
cord-001835-0s7ok4uw	5944	21	structures	structure	NNS
cord-001835-0s7ok4uw	5944	22	and	and	CC
cord-001835-0s7ok4uw	5944	23	models	model	NNS
cord-001835-0s7ok4uw	5944	24	of	of	IN
cord-001835-0s7ok4uw	5944	25	PPI	PPI	NNP
cord-001835-0s7ok4uw	5944	26	on	on	IN
cord-001835-0s7ok4uw	5944	27	a	a	DT
cord-001835-0s7ok4uw	5944	28	genomic	genomic	JJ
cord-001835-0s7ok4uw	5944	29	scale	scale	NN
cord-001835-0s7ok4uw	5944	30	.	.	.
cord-001835-0s7ok4uw	5945	1	Currently	currently	RB
cord-001835-0s7ok4uw	5945	2	,	,	,
cord-001835-0s7ok4uw	5945	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	5945	4	are	be	VBP
cord-001835-0s7ok4uw	5945	5	expanding	expand	VBG
cord-001835-0s7ok4uw	5945	6	the	the	DT
cord-001835-0s7ok4uw	5945	7	GWIDD	GWIDD	NNP
cord-001835-0s7ok4uw	5945	8	dataset	dataset	NN
cord-001835-0s7ok4uw	5945	9	to	to	IN
cord-001835-0s7ok4uw	5945	10	800,365	800,365	CD
cord-001835-0s7ok4uw	5945	11	PPI	ppi	NN
cord-001835-0s7ok4uw	5945	12	in	in	IN
cord-001835-0s7ok4uw	5945	13	1,652	1,652	CD
cord-001835-0s7ok4uw	5945	14	organisms	organism	NNS
cord-001835-0s7ok4uw	5945	15	,	,	,
cord-001835-0s7ok4uw	5945	16	up	up	RB
cord-001835-0s7ok4uw	5945	17	from	from	IN
cord-001835-0s7ok4uw	5945	18	128,818	128,818	CD
cord-001835-0s7ok4uw	5945	19	PPI	PPI	NNP
cord-001835-0s7ok4uw	5945	20	in	in	IN
cord-001835-0s7ok4uw	5945	21	771	771	CD
cord-001835-0s7ok4uw	5945	22	organisms	organism	NNS
cord-001835-0s7ok4uw	5945	23	in	in	IN
cord-001835-0s7ok4uw	5945	24	the	the	DT
cord-001835-0s7ok4uw	5945	25	previous	previous	JJ
cord-001835-0s7ok4uw	5945	26	release	release	NN
cord-001835-0s7ok4uw	5945	27	.	.	.
cord-001835-0s7ok4uw	5946	1	The	the	DT
cord-001835-0s7ok4uw	5946	2	PPI	PPI	NNP
cord-001835-0s7ok4uw	5946	3	data	datum	NNS
cord-001835-0s7ok4uw	5946	4	were	be	VBD
cord-001835-0s7ok4uw	5946	5	imported	import	VBN
cord-001835-0s7ok4uw	5946	6	from	from	IN
cord-001835-0s7ok4uw	5946	7	INTACT	intact	JJ
cord-001835-0s7ok4uw	5946	8	and	and	CC
cord-001835-0s7ok4uw	5946	9	BIOGRID	BIOGRID	NNP
cord-001835-0s7ok4uw	5946	10	databases	database	NNS
cord-001835-0s7ok4uw	5946	11	and	and	CC
cord-001835-0s7ok4uw	5946	12	were	be	VBD
cord-001835-0s7ok4uw	5946	13	subjected	subject	VBN
cord-001835-0s7ok4uw	5946	14	to	to	IN
cord-001835-0s7ok4uw	5946	15	in	in	IN
cord-001835-0s7ok4uw	5946	16	-	-	HYPH
cord-001835-0s7ok4uw	5946	17	house	house	NN
cord-001835-0s7ok4uw	5946	18	modeling	modeling	NN
cord-001835-0s7ok4uw	5946	19	pipeline	pipeline	NN
cord-001835-0s7ok4uw	5946	20	.	.	.
cord-001835-0s7ok4uw	5947	1	GWIDD	GWIDD	NNP
cord-001835-0s7ok4uw	5947	2	current	current	JJ
cord-001835-0s7ok4uw	5947	3	implementation	implementation	NN
cord-001835-0s7ok4uw	5947	4	contains	contain	VBZ
cord-001835-0s7ok4uw	5947	5	11,073	11,073	CD
cord-001835-0s7ok4uw	5947	6	experimentally	experimentally	RB
cord-001835-0s7ok4uw	5947	7	determined	determine	VBN
cord-001835-0s7ok4uw	5947	8	complexes	complex	NNS
cord-001835-0s7ok4uw	5947	9	,	,	,
cord-001835-0s7ok4uw	5947	10	and	and	CC
cord-001835-0s7ok4uw	5947	11	12,426	12,426	CD
cord-001835-0s7ok4uw	5947	12	sequence	sequence	NN
cord-001835-0s7ok4uw	5947	13	homology	homology	NN
cord-001835-0s7ok4uw	5947	14	and	and	CC
cord-001835-0s7ok4uw	5947	15	28,811	28,811	CD
cord-001835-0s7ok4uw	5947	16	structure	structure	NN
cord-001835-0s7ok4uw	5947	17	homology	homology	NN
cord-001835-0s7ok4uw	5947	18	models	model	NNS
cord-001835-0s7ok4uw	5947	19	of	of	IN
cord-001835-0s7ok4uw	5947	20	complexes	complex	NNS
cord-001835-0s7ok4uw	5947	21	.	.	.
cord-001835-0s7ok4uw	5948	1	The	the	DT
cord-001835-0s7ok4uw	5948	2	user	user	NN
cord-001835-0s7ok4uw	5948	3	-	-	HYPH
cord-001835-0s7ok4uw	5948	4	friendly	friendly	JJ
cord-001835-0s7ok4uw	5948	5	interface	interface	NN
cord-001835-0s7ok4uw	5948	6	offers	offer	VBZ
cord-001835-0s7ok4uw	5948	7	flexible	flexible	JJ
cord-001835-0s7ok4uw	5948	8	organism	organism	NN
cord-001835-0s7ok4uw	5948	9	-	-	HYPH
cord-001835-0s7ok4uw	5948	10	specific	specific	JJ
cord-001835-0s7ok4uw	5948	11	search	search	NN
cord-001835-0s7ok4uw	5948	12	with	with	IN
cord-001835-0s7ok4uw	5948	13	advanced	advanced	JJ
cord-001835-0s7ok4uw	5948	14	functions	function	NNS
cord-001835-0s7ok4uw	5948	15	for	for	IN
cord-001835-0s7ok4uw	5948	16	a	a	DT
cord-001835-0s7ok4uw	5948	17	refined	refined	JJ
cord-001835-0s7ok4uw	5948	18	search	search	NN
cord-001835-0s7ok4uw	5948	19	for	for	IN
cord-001835-0s7ok4uw	5948	20	one	one	CD
cord-001835-0s7ok4uw	5948	21	or	or	CC
cord-001835-0s7ok4uw	5948	22	both	both	DT
cord-001835-0s7ok4uw	5948	23	proteins	protein	NNS
cord-001835-0s7ok4uw	5948	24	.	.	.
cord-001835-0s7ok4uw	5949	1	The	the	DT
cord-001835-0s7ok4uw	5949	2	new	new	JJ
cord-001835-0s7ok4uw	5949	3	GWIDD	GWIDD	NNP
cord-001835-0s7ok4uw	5949	4	version	version	NN
cord-001835-0s7ok4uw	5949	5	includes	include	VBZ
cord-001835-0s7ok4uw	5949	6	also	also	RB
cord-001835-0s7ok4uw	5949	7	a	a	DT
cord-001835-0s7ok4uw	5949	8	new	new	JJ
cord-001835-0s7ok4uw	5949	9	interactive	interactive	JJ
cord-001835-0s7ok4uw	5949	10	visualization	visualization	NN
cord-001835-0s7ok4uw	5949	11	screen	screen	NN
cord-001835-0s7ok4uw	5949	12	that	that	WDT
cord-001835-0s7ok4uw	5949	13	allows	allow	VBZ
cord-001835-0s7ok4uw	5949	14	to	to	TO
cord-001835-0s7ok4uw	5949	15	view	view	VB
cord-001835-0s7ok4uw	5949	16	search	search	NN
cord-001835-0s7ok4uw	5949	17	results	result	NNS
cord-001835-0s7ok4uw	5949	18	in	in	IN
cord-001835-0s7ok4uw	5949	19	different	different	JJ
cord-001835-0s7ok4uw	5949	20	residue	residue	NN
cord-001835-0s7ok4uw	5949	21	representations	representation	NNS
cord-001835-0s7ok4uw	5949	22	with	with	IN
cord-001835-0s7ok4uw	5949	23	the	the	DT
cord-001835-0s7ok4uw	5949	24	emphasis	emphasis	NN
cord-001835-0s7ok4uw	5949	25	on	on	IN
cord-001835-0s7ok4uw	5949	26	the	the	DT
cord-001835-0s7ok4uw	5949	27	PPI	PPI	NNP
cord-001835-0s7ok4uw	5949	28	interface	interface	NN
cord-001835-0s7ok4uw	5949	29	Refolding	Refolding	NNP
cord-001835-0s7ok4uw	5949	30	and	and	CC
cord-001835-0s7ok4uw	5949	31	activation	activation	NN
cord-001835-0s7ok4uw	5949	32	of	of	IN
cord-001835-0s7ok4uw	5949	33	recombinant	recombinant	JJ
cord-001835-0s7ok4uw	5949	34	trypsin	trypsin	NN
cord-001835-0s7ok4uw	5949	35	i	i	PRP
cord-001835-0s7ok4uw	5949	36	from	from	IN
cord-001835-0s7ok4uw	5949	37	sardine	sardine	NN
cord-001835-0s7ok4uw	5949	38	fish	fish	NN
cord-001835-0s7ok4uw	5949	39	(	(	-LRB-
cord-001835-0s7ok4uw	5949	40	sardinops	sardinops	NNP
cord-001835-0s7ok4uw	5949	41	sagax	sagax	NNP
cord-001835-0s7ok4uw	5949	42	caerulea	caerulea	NNP
cord-001835-0s7ok4uw	5949	43	)	)	-RRB-
cord-001835-0s7ok4uw	5950	1	Amyloid	amyloid	NN
cord-001835-0s7ok4uw	5950	2	is	be	VBZ
cord-001835-0s7ok4uw	5950	3	detectable	detectable	JJ
cord-001835-0s7ok4uw	5950	4	in	in	IN
cord-001835-0s7ok4uw	5950	5	human	human	JJ
cord-001835-0s7ok4uw	5950	6	dental	dental	JJ
cord-001835-0s7ok4uw	5950	7	plaque	plaque	NN
cord-001835-0s7ok4uw	5950	8	and	and	CC
cord-001835-0s7ok4uw	5950	9	is	be	VBZ
cord-001835-0s7ok4uw	5950	10	produced	produce	VBN
cord-001835-0s7ok4uw	5950	11	by	by	IN
cord-001835-0s7ok4uw	5950	12	both	both	CC
cord-001835-0s7ok4uw	5950	13	clinical	clinical	JJ
cord-001835-0s7ok4uw	5950	14	and	and	CC
cord-001835-0s7ok4uw	5950	15	laboratory	laboratory	NN
cord-001835-0s7ok4uw	5950	16	strains	strain	NNS
cord-001835-0s7ok4uw	5950	17	of	of	IN
cord-001835-0s7ok4uw	5950	18	S.	S.	NNP
cord-001835-0s7ok4uw	5950	19	mutans	mutan	NNS
cord-001835-0s7ok4uw	5950	20	,	,	,
cord-001835-0s7ok4uw	5950	21	further	further	RB
cord-001835-0s7ok4uw	5950	22	supporting	support	VBG
cord-001835-0s7ok4uw	5950	23	a	a	DT
cord-001835-0s7ok4uw	5950	24	functional	functional	JJ
cord-001835-0s7ok4uw	5950	25	role	role	NN
cord-001835-0s7ok4uw	5950	26	.	.	.
cord-001835-0s7ok4uw	5951	1	S.	S.	NNP
cord-001835-0s7ok4uw	5951	2	mutans	mutan	NNS
cord-001835-0s7ok4uw	5951	3	lacking	lack	VBG
cord-001835-0s7ok4uw	5951	4	P1	P1	NNP
cord-001835-0s7ok4uw	5951	5	demonstrates	demonstrate	VBZ
cord-001835-0s7ok4uw	5951	6	residual	residual	JJ
cord-001835-0s7ok4uw	5951	7	amyloid	amyloid	NN
cord-001835-0s7ok4uw	5951	8	forming	form	VBG
cord-001835-0s7ok4uw	5951	9	properties	property	NNS
cord-001835-0s7ok4uw	5951	10	,	,	,
cord-001835-0s7ok4uw	5951	11	however	however	RB
cord-001835-0s7ok4uw	5951	12	,	,	,
cord-001835-0s7ok4uw	5951	13	a	a	DT
cord-001835-0s7ok4uw	5951	14	mutant	mutant	JJ
cord-001835-0s7ok4uw	5951	15	lacking	lack	VBG
cord-001835-0s7ok4uw	5951	16	sortase	sortase	NN
cord-001835-0s7ok4uw	5951	17	,	,	,
cord-001835-0s7ok4uw	5951	18	the	the	DT
cord-001835-0s7ok4uw	5951	19	transpeptidase	transpeptidase	NN
cord-001835-0s7ok4uw	5951	20	which	which	WDT
cord-001835-0s7ok4uw	5951	21	covalently	covalently	RB
cord-001835-0s7ok4uw	5951	22	links	link	VBZ
cord-001835-0s7ok4uw	5951	23	P1	P1	NNP
cord-001835-0s7ok4uw	5951	24	and	and	CC
cord-001835-0s7ok4uw	5951	25	several	several	JJ
cord-001835-0s7ok4uw	5951	26	other	other	JJ
cord-001835-0s7ok4uw	5951	27	proteins	protein	NNS
cord-001835-0s7ok4uw	5951	28	to	to	IN
cord-001835-0s7ok4uw	5951	29	the	the	DT
cord-001835-0s7ok4uw	5951	30	peptidoglycan	peptidoglycan	JJ
cord-001835-0s7ok4uw	5951	31	cell	cell	NN
cord-001835-0s7ok4uw	5951	32	wall	wall	NN
cord-001835-0s7ok4uw	5951	33	,	,	,
cord-001835-0s7ok4uw	5951	34	is	be	VBZ
cord-001835-0s7ok4uw	5951	35	defective	defective	JJ
cord-001835-0s7ok4uw	5951	36	in	in	IN
cord-001835-0s7ok4uw	5951	37	cell	cell	NN
cord-001835-0s7ok4uw	5951	38	-	-	HYPH
cord-001835-0s7ok4uw	5951	39	associated	associate	VBN
cord-001835-0s7ok4uw	5951	40	amyloid	amyloid	NN
cord-001835-0s7ok4uw	5951	41	-	-	HYPH
cord-001835-0s7ok4uw	5951	42	like	like	JJ
cord-001835-0s7ok4uw	5951	43	properties	property	NNS
cord-001835-0s7ok4uw	5951	44	.	.	.
cord-001835-0s7ok4uw	5952	1	The	the	DT
cord-001835-0s7ok4uw	5952	2	objectives	objective	NNS
cord-001835-0s7ok4uw	5952	3	of	of	IN
cord-001835-0s7ok4uw	5952	4	this	this	DT
cord-001835-0s7ok4uw	5952	5	study	study	NN
cord-001835-0s7ok4uw	5952	6	were	be	VBD
cord-001835-0s7ok4uw	5952	7	to	to	TO
cord-001835-0s7ok4uw	5952	8	identify	identify	VB
cord-001835-0s7ok4uw	5952	9	additional	additional	JJ
cord-001835-0s7ok4uw	5952	10	amyloid	amyloid	NN
cord-001835-0s7ok4uw	5952	11	forming	form	VBG
cord-001835-0s7ok4uw	5952	12	proteins	protein	NNS
cord-001835-0s7ok4uw	5952	13	of	of	IN
cord-001835-0s7ok4uw	5952	14	S.	S.	NNP
cord-001835-0s7ok4uw	5952	15	mutans	mutan	NNS
cord-001835-0s7ok4uw	5952	16	and	and	CC
cord-001835-0s7ok4uw	5952	17	to	to	TO
cord-001835-0s7ok4uw	5952	18	evaluate	evaluate	VB
cord-001835-0s7ok4uw	5952	19	the	the	DT
cord-001835-0s7ok4uw	5952	20	effects	effect	NNS
cord-001835-0s7ok4uw	5952	21	of	of	IN
cord-001835-0s7ok4uw	5952	22	buffering	buffer	VBG
cord-001835-0s7ok4uw	5952	23	conditions	condition	NNS
cord-001835-0s7ok4uw	5952	24	and	and	CC
cord-001835-0s7ok4uw	5952	25	pH	ph	NN
cord-001835-0s7ok4uw	5952	26	on	on	IN
cord-001835-0s7ok4uw	5952	27	the	the	DT
cord-001835-0s7ok4uw	5952	28	ability	ability	NN
cord-001835-0s7ok4uw	5952	29	of	of	IN
cord-001835-0s7ok4uw	5952	30	the	the	DT
cord-001835-0s7ok4uw	5952	31	identified	identify	VBN
cord-001835-0s7ok4uw	5952	32	proteins	protein	NNS
cord-001835-0s7ok4uw	5952	33	to	to	TO
cord-001835-0s7ok4uw	5952	34	form	form	VB
cord-001835-0s7ok4uw	5952	35	amyloids	amyloid	NNS
cord-001835-0s7ok4uw	5952	36	.	.	.
cord-001835-0s7ok4uw	5953	1	A	a	DT
cord-001835-0s7ok4uw	5953	2	P1-deficient	p1-deficient	CD
cord-001835-0s7ok4uw	5953	3	mutant	mutant	JJ
cord-001835-0s7ok4uw	5953	4	strain	strain	NN
cord-001835-0s7ok4uw	5953	5	was	be	VBD
cord-001835-0s7ok4uw	5953	6	grown	grow	VBN
cord-001835-0s7ok4uw	5953	7	to	to	IN
cord-001835-0s7ok4uw	5953	8	stationary	stationary	JJ
cord-001835-0s7ok4uw	5953	9	-	-	HYPH
cord-001835-0s7ok4uw	5953	10	phase	phase	NN
cord-001835-0s7ok4uw	5953	11	in	in	IN
cord-001835-0s7ok4uw	5953	12	defined	define	VBN
cord-001835-0s7ok4uw	5953	13	minimal	minimal	JJ
cord-001835-0s7ok4uw	5953	14	media	medium	NNS
cord-001835-0s7ok4uw	5953	15	,	,	,
cord-001835-0s7ok4uw	5953	16	and	and	CC
cord-001835-0s7ok4uw	5953	17	secreted	secrete	VBD
cord-001835-0s7ok4uw	5953	18	proteins	protein	NNS
cord-001835-0s7ok4uw	5953	19	from	from	IN
cord-001835-0s7ok4uw	5953	20	spent	spend	VBN
cord-001835-0s7ok4uw	5953	21	culture	culture	NN
cord-001835-0s7ok4uw	5953	22	supernatants	supernatant	NNS
cord-001835-0s7ok4uw	5953	23	were	be	VBD
cord-001835-0s7ok4uw	5953	24	fractionated	fractionate	VBN
cord-001835-0s7ok4uw	5953	25	by	by	IN
cord-001835-0s7ok4uw	5953	26	ion	ion	NN
cord-001835-0s7ok4uw	5953	27	exchange	exchange	NN
cord-001835-0s7ok4uw	5953	28	chromatography	chromatography	NN
cord-001835-0s7ok4uw	5953	29	.	.	.
cord-001835-0s7ok4uw	5954	1	Partially	partially	RB
cord-001835-0s7ok4uw	5954	2	purified	purify	VBN
cord-001835-0s7ok4uw	5954	3	protein	protein	NN
cord-001835-0s7ok4uw	5954	4	fractions	fraction	NNS
cord-001835-0s7ok4uw	5954	5	were	be	VBD
cord-001835-0s7ok4uw	5954	6	tested	test	VBN
cord-001835-0s7ok4uw	5954	7	for	for	IN
cord-001835-0s7ok4uw	5954	8	binding	bind	VBG
cord-001835-0s7ok4uw	5954	9	of	of	IN
cord-001835-0s7ok4uw	5954	10	the	the	DT
cord-001835-0s7ok4uw	5954	11	amyloidophilic	amyloidophilic	JJ
cord-001835-0s7ok4uw	5954	12	dyes	dye	NNS
cord-001835-0s7ok4uw	5954	13	Congo	Congo	NNP
cord-001835-0s7ok4uw	5954	14	Red	Red	NNP
cord-001835-0s7ok4uw	5954	15	(	(	-LRB-
cord-001835-0s7ok4uw	5954	16	CR	CR	NNP
cord-001835-0s7ok4uw	5954	17	)	)	-RRB-
cord-001835-0s7ok4uw	5954	18	and	and	CC
cord-001835-0s7ok4uw	5954	19	Thioflavin	Thioflavin	NNP
cord-001835-0s7ok4uw	5954	20	T	T	NNP
cord-001835-0s7ok4uw	5954	21	(	(	-LRB-
cord-001835-0s7ok4uw	5954	22	ThT	ThT	NNP
cord-001835-0s7ok4uw	5954	23	)	)	-RRB-
cord-001835-0s7ok4uw	5954	24	,	,	,
cord-001835-0s7ok4uw	5954	25	and	and	CC
cord-001835-0s7ok4uw	5954	26	for	for	IN
cord-001835-0s7ok4uw	5954	27	characteristic	characteristic	JJ
cord-001835-0s7ok4uw	5954	28	birefringent	birefringent	JJ
cord-001835-0s7ok4uw	5954	29	properties	property	NNS
cord-001835-0s7ok4uw	5954	30	following	follow	VBG
cord-001835-0s7ok4uw	5954	31	staining	stain	VBG
cord-001835-0s7ok4uw	5954	32	with	with	IN
cord-001835-0s7ok4uw	5954	33	CR	cr	NN
cord-001835-0s7ok4uw	5954	34	and	and	CC
cord-001835-0s7ok4uw	5954	35	visualization	visualization	NN
cord-001835-0s7ok4uw	5954	36	under	under	IN
cord-001835-0s7ok4uw	5954	37	crossed	cross	VBD
cord-001835-0s7ok4uw	5954	38	polarizing	polarize	VBG
cord-001835-0s7ok4uw	5954	39	filters	filter	NNS
cord-001835-0s7ok4uw	5954	40	.	.	.
cord-001835-0s7ok4uw	5955	1	Proteins	protein	NNS
cord-001835-0s7ok4uw	5955	2	from	from	IN
cord-001835-0s7ok4uw	5955	3	fractions	fraction	NNS
cord-001835-0s7ok4uw	5955	4	that	that	WDT
cord-001835-0s7ok4uw	5955	5	tested	test	VBD
cord-001835-0s7ok4uw	5955	6	positive	positive	JJ
cord-001835-0s7ok4uw	5955	7	for	for	IN
cord-001835-0s7ok4uw	5955	8	amyloid	amyloid	NN
cord-001835-0s7ok4uw	5955	9	-	-	HYPH
cord-001835-0s7ok4uw	5955	10	like	like	JJ
cord-001835-0s7ok4uw	5955	11	material	material	NN
cord-001835-0s7ok4uw	5955	12	were	be	VBD
cord-001835-0s7ok4uw	5955	13	separated	separate	VBN
cord-001835-0s7ok4uw	5955	14	by	by	IN
cord-001835-0s7ok4uw	5955	15	SDS	SDS	NNP
cord-001835-0s7ok4uw	5955	16	PAGE	PAGE	NNP
cord-001835-0s7ok4uw	5955	17	,	,	,
cord-001835-0s7ok4uw	5955	18	and	and	CC
cord-001835-0s7ok4uw	5955	19	identified	identify	VBN
cord-001835-0s7ok4uw	5955	20	by	by	IN
cord-001835-0s7ok4uw	5955	21	LC	LC	NNP
cord-001835-0s7ok4uw	5955	22	/	/	SYM
cord-001835-0s7ok4uw	5955	23	MS	MS	NNP
cord-001835-0s7ok4uw	5955	24	.	.	.
cord-001835-0s7ok4uw	5956	1	These	these	DT
cord-001835-0s7ok4uw	5956	2	included	include	VBD
cord-001835-0s7ok4uw	5956	3	WapA	WapA	NNP
cord-001835-0s7ok4uw	5956	4	,	,	,
cord-001835-0s7ok4uw	5956	5	GbpA	GbpA	NNP
cord-001835-0s7ok4uw	5956	6	,	,	,
cord-001835-0s7ok4uw	5956	7	GbpB	GbpB	NNP
cord-001835-0s7ok4uw	5956	8	,	,	,
cord-001835-0s7ok4uw	5956	9	SMU_2147c	SMU_2147c	NNP
cord-001835-0s7ok4uw	5956	10	and	and	CC
cord-001835-0s7ok4uw	5956	11	SMU_63c	SMU_63c	NNP
cord-001835-0s7ok4uw	5956	12	.	.	.
cord-001835-0s7ok4uw	5957	1	Recombinant	recombinant	JJ
cord-001835-0s7ok4uw	5957	2	proteins	protein	NNS
cord-001835-0s7ok4uw	5957	3	were	be	VBD
cord-001835-0s7ok4uw	5957	4	expressed	express	VBN
cord-001835-0s7ok4uw	5957	5	in	in	IN
cord-001835-0s7ok4uw	5957	6	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	5957	7	coli	coli	NNS
cord-001835-0s7ok4uw	5957	8	,	,	,
cord-001835-0s7ok4uw	5957	9	and	and	CC
cord-001835-0s7ok4uw	5957	10	purified	purify	VBN
cord-001835-0s7ok4uw	5957	11	for	for	IN
cord-001835-0s7ok4uw	5957	12	confirmation	confirmation	NN
cord-001835-0s7ok4uw	5957	13	and	and	CC
cord-001835-0s7ok4uw	5957	14	characterization	characterization	NN
cord-001835-0s7ok4uw	5957	15	of	of	IN
cord-001835-0s7ok4uw	5957	16	individual	individual	JJ
cord-001835-0s7ok4uw	5957	17	amyloidogenic	amyloidogenic	NNP
cord-001835-0s7ok4uw	5957	18	properties	property	NNS
cord-001835-0s7ok4uw	5957	19	in	in	IN
cord-001835-0s7ok4uw	5957	20	vitro	vitro	FW
cord-001835-0s7ok4uw	5957	21	.	.	.
cord-001835-0s7ok4uw	5958	1	Recombinant	Recombinant	NNP
cord-001835-0s7ok4uw	5958	2	WapA	WapA	NNP
cord-001835-0s7ok4uw	5958	3	and	and	CC
cord-001835-0s7ok4uw	5958	4	SMU_63c	SMU_63c	NNP
cord-001835-0s7ok4uw	5958	5	displayed	display	VBD
cord-001835-0s7ok4uw	5958	6	all	all	PDT
cord-001835-0s7ok4uw	5958	7	the	the	DT
cord-001835-0s7ok4uw	5958	8	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	5958	9	characteristics	characteristic	NNS
cord-001835-0s7ok4uw	5958	10	of	of	IN
cord-001835-0s7ok4uw	5958	11	amyloid	amyloid	NN
cord-001835-0s7ok4uw	5958	12	,	,	,
cord-001835-0s7ok4uw	5958	13	including	include	VBG
cord-001835-0s7ok4uw	5958	14	visualization	visualization	NN
cord-001835-0s7ok4uw	5958	15	of	of	IN
cord-001835-0s7ok4uw	5958	16	fibrillar	fibrillar	NNP
cord-001835-0s7ok4uw	5958	17	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	5958	18	when	when	WRB
cord-001835-0s7ok4uw	5958	19	viewed	view	VBN
cord-001835-0s7ok4uw	5958	20	by	by	IN
cord-001835-0s7ok4uw	5958	21	transmission	transmission	NN
cord-001835-0s7ok4uw	5958	22	electron	electron	NN
cord-001835-0s7ok4uw	5958	23	microscopy	microscopy	NN
cord-001835-0s7ok4uw	5958	24	.	.	.
cord-001835-0s7ok4uw	5959	1	In	in	IN
cord-001835-0s7ok4uw	5959	2	contrast	contrast	NN
cord-001835-0s7ok4uw	5959	3	,	,	,
cord-001835-0s7ok4uw	5959	4	GbpA	GbpA	NNP
cord-001835-0s7ok4uw	5959	5	and	and	CC
cord-001835-0s7ok4uw	5959	6	SMU_2147c	smu_2147c	NN
cord-001835-0s7ok4uw	5959	7	produced	produce	VBD
cord-001835-0s7ok4uw	5959	8	amorphous	amorphous	JJ
cord-001835-0s7ok4uw	5959	9	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	5959	10	.	.	.
cord-001835-0s7ok4uw	5960	1	WapA	WapA	NNP
cord-001835-0s7ok4uw	5960	2	and	and	CC
cord-001835-0s7ok4uw	5960	3	SMU_63c	SMU_63c	NNP
cord-001835-0s7ok4uw	5960	4	form	form	NNP
cord-001835-0s7ok4uw	5960	5	amyloid	amyloid	NN
cord-001835-0s7ok4uw	5960	6	at	at	IN
cord-001835-0s7ok4uw	5960	7	different	different	JJ
cord-001835-0s7ok4uw	5960	8	pH	pH	NNP
cord-001835-0s7ok4uw	5960	9	,	,	,
cord-001835-0s7ok4uw	5960	10	SMU_63c	SMU_63c	NNP
cord-001835-0s7ok4uw	5960	11	under	under	IN
cord-001835-0s7ok4uw	5960	12	acidic	acidic	JJ
cord-001835-0s7ok4uw	5960	13	conditions	condition	NNS
cord-001835-0s7ok4uw	5960	14	and	and	CC
cord-001835-0s7ok4uw	5960	15	WapA	WapA	NNP
cord-001835-0s7ok4uw	5960	16	under	under	IN
cord-001835-0s7ok4uw	5960	17	neutral	neutral	JJ
cord-001835-0s7ok4uw	5960	18	to	to	IN
cord-001835-0s7ok4uw	5960	19	basic	basic	JJ
cord-001835-0s7ok4uw	5960	20	conditions	condition	NNS
cord-001835-0s7ok4uw	5960	21	.	.	.
cord-001835-0s7ok4uw	5961	1	This	this	DT
cord-001835-0s7ok4uw	5961	2	suggests	suggest	VBZ
cord-001835-0s7ok4uw	5961	3	that	that	IN
cord-001835-0s7ok4uw	5961	4	the	the	DT
cord-001835-0s7ok4uw	5961	5	prevailing	prevail	VBG
cord-001835-0s7ok4uw	5961	6	environmental	environmental	JJ
cord-001835-0s7ok4uw	5961	7	pH	ph	NN
cord-001835-0s7ok4uw	5961	8	may	may	MD
cord-001835-0s7ok4uw	5961	9	represent	represent	VB
cord-001835-0s7ok4uw	5961	10	different	different	JJ
cord-001835-0s7ok4uw	5961	11	in	in	IN
cord-001835-0s7ok4uw	5961	12	vivo	vivo	NN
cord-001835-0s7ok4uw	5961	13	triggers	trigger	NNS
cord-001835-0s7ok4uw	5961	14	for	for	IN
cord-001835-0s7ok4uw	5961	15	amyloid	amyloid	NN
cord-001835-0s7ok4uw	5961	16	fibrillization	fibrillization	NN
cord-001835-0s7ok4uw	5961	17	of	of	IN
cord-001835-0s7ok4uw	5961	18	different	different	JJ
cord-001835-0s7ok4uw	5961	19	S	s	NN
cord-001835-0s7ok4uw	5962	1	Like	like	IN
cord-001835-0s7ok4uw	5962	2	other	other	JJ
cord-001835-0s7ok4uw	5962	3	small	small	JJ
cord-001835-0s7ok4uw	5962	4	GTPases	gtpase	NNS
cord-001835-0s7ok4uw	5962	5	,	,	,
cord-001835-0s7ok4uw	5962	6	the	the	DT
cord-001835-0s7ok4uw	5962	7	activity	activity	NN
cord-001835-0s7ok4uw	5962	8	of	of	IN
cord-001835-0s7ok4uw	5962	9	Rheb	Rheb	NNP
cord-001835-0s7ok4uw	5962	10	is	be	VBZ
cord-001835-0s7ok4uw	5962	11	dictated	dictate	VBN
cord-001835-0s7ok4uw	5962	12	by	by	IN
cord-001835-0s7ok4uw	5962	13	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5962	14	guanine	guanine	NN
cord-001835-0s7ok4uw	5962	15	nucleotide	nucleotide	NN
cord-001835-0s7ok4uw	5962	16	binding	bind	VBG
cord-001835-0s7ok4uw	5962	17	states	state	NNS
cord-001835-0s7ok4uw	5962	18	:	:	:
cord-001835-0s7ok4uw	5962	19	it	-PRON-	PRP
cord-001835-0s7ok4uw	5962	20	is	be	VBZ
cord-001835-0s7ok4uw	5962	21	active	active	JJ
cord-001835-0s7ok4uw	5962	22	in	in	IN
cord-001835-0s7ok4uw	5962	23	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5962	24	guanosine	guanosine	NN
cord-001835-0s7ok4uw	5962	25	5	5	CD
cord-001835-0s7ok4uw	5962	26	0	0	CD
cord-001835-0s7ok4uw	5963	1	-triphosphate	-triphosphate	.
cord-001835-0s7ok4uw	5964	1	(	(	-LRB-
cord-001835-0s7ok4uw	5964	2	GTP	GTP	NNP
cord-001835-0s7ok4uw	5964	3	)	)	-RRB-
cord-001835-0s7ok4uw	5964	4	bound	bind	VBN
cord-001835-0s7ok4uw	5964	5	form	form	NN
cord-001835-0s7ok4uw	5964	6	and	and	CC
cord-001835-0s7ok4uw	5964	7	inactive	inactive	JJ
cord-001835-0s7ok4uw	5964	8	in	in	IN
cord-001835-0s7ok4uw	5964	9	the	the	DT
cord-001835-0s7ok4uw	5964	10	guanosine	guanosine	NN
cord-001835-0s7ok4uw	5964	11	diphosphate	diphosphate	NN
cord-001835-0s7ok4uw	5964	12	(	(	-LRB-
cord-001835-0s7ok4uw	5964	13	GDP)-bound	gdp)-bound	NN
cord-001835-0s7ok4uw	5964	14	form	form	NN
cord-001835-0s7ok4uw	5964	15	.	.	.
cord-001835-0s7ok4uw	5965	1	Rheb	rheb	NN
cord-001835-0s7ok4uw	5965	2	proteins	protein	NNS
cord-001835-0s7ok4uw	5965	3	play	play	VBP
cord-001835-0s7ok4uw	5965	4	critical	critical	JJ
cord-001835-0s7ok4uw	5965	5	roles	role	NNS
cord-001835-0s7ok4uw	5965	6	in	in	IN
cord-001835-0s7ok4uw	5965	7	regulating	regulate	VBG
cord-001835-0s7ok4uw	5965	8	growth	growth	NN
cord-001835-0s7ok4uw	5965	9	and	and	CC
cord-001835-0s7ok4uw	5965	10	cell	cell	NN
cord-001835-0s7ok4uw	5965	11	cycle	cycle	NN
cord-001835-0s7ok4uw	5965	12	,	,	,
cord-001835-0s7ok4uw	5965	13	and	and	CC
cord-001835-0s7ok4uw	5965	14	this	this	DT
cord-001835-0s7ok4uw	5965	15	effect	effect	NN
cord-001835-0s7ok4uw	5965	16	is	be	VBZ
cord-001835-0s7ok4uw	5965	17	due	due	JJ
cord-001835-0s7ok4uw	5965	18	to	to	IN
cord-001835-0s7ok4uw	5965	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5965	20	role	role	NN
cord-001835-0s7ok4uw	5965	21	in	in	IN
cord-001835-0s7ok4uw	5965	22	regulating	regulate	VBG
cord-001835-0s7ok4uw	5965	23	the	the	DT
cord-001835-0s7ok4uw	5965	24	insulin	insulin	NN
cord-001835-0s7ok4uw	5965	25	/	/	SYM
cord-001835-0s7ok4uw	5965	26	TOR	TOR	NNP
cord-001835-0s7ok4uw	5965	27	/	/	SYM
cord-001835-0s7ok4uw	5965	28	S6	S6	NNP
cord-001835-0s7ok4uw	5965	29	K	K	NNP
cord-001835-0s7ok4uw	5965	30	signaling	signal	VBG
cord-001835-0s7ok4uw	5966	1	pathway	pathway	NNP
cord-001835-0s7ok4uw	5966	2	Rheb	Rheb	NNP
cord-001835-0s7ok4uw	5966	3	interacts	interact	VBZ
cord-001835-0s7ok4uw	5966	4	directly	directly	RB
cord-001835-0s7ok4uw	5966	5	with	with	IN
cord-001835-0s7ok4uw	5966	6	FKBP38	FKBP38	NNP
cord-001835-0s7ok4uw	5966	7	and	and	CC
cord-001835-0s7ok4uw	5966	8	prevents	prevent	VBZ
cord-001835-0s7ok4uw	5966	9	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5966	10	association	association	NN
cord-001835-0s7ok4uw	5966	11	with	with	IN
cord-001835-0s7ok4uw	5966	12	mTOR	mTOR	NNP
cord-001835-0s7ok4uw	5966	13	in	in	IN
cord-001835-0s7ok4uw	5966	14	a	a	DT
cord-001835-0s7ok4uw	5966	15	GTP	gtp	NN
cord-001835-0s7ok4uw	5966	16	-	-	HYPH
cord-001835-0s7ok4uw	5966	17	dependent	dependent	JJ
cord-001835-0s7ok4uw	5966	18	manner	manner	NN
cord-001835-0s7ok4uw	5966	19	.	.	.
cord-001835-0s7ok4uw	5967	1	Moreover	moreover	RB
cord-001835-0s7ok4uw	5967	2	,	,	,
cord-001835-0s7ok4uw	5967	3	FKBP38	FKBP38	NNP
cord-001835-0s7ok4uw	5967	4	bound	bind	VBN
cord-001835-0s7ok4uw	5967	5	to	to	IN
cord-001835-0s7ok4uw	5967	6	GTP	GTP	NNP
cord-001835-0s7ok4uw	5967	7	-	-	HYPH
cord-001835-0s7ok4uw	5967	8	g	g	NNP
cord-001835-0s7ok4uw	5967	9	-	-	HYPH
cord-001835-0s7ok4uw	5967	10	S	S	NNP
cord-001835-0s7ok4uw	5967	11	,	,	,
cord-001835-0s7ok4uw	5967	12	a	a	DT
cord-001835-0s7ok4uw	5967	13	nonhydrolyzable	nonhydrolyzable	JJ
cord-001835-0s7ok4uw	5967	14	GTP	GTP	NNP
cord-001835-0s7ok4uw	5967	15	analogon	analogon	NNP
cord-001835-0s7ok4uw	5967	16	,	,	,
cord-001835-0s7ok4uw	5967	17	has	have	VBZ
cord-001835-0s7ok4uw	5967	18	a	a	DT
cord-001835-0s7ok4uw	5967	19	much	much	RB
cord-001835-0s7ok4uw	5967	20	higher	high	JJR
cord-001835-0s7ok4uw	5967	21	binding	bind	VBG
cord-001835-0s7ok4uw	5967	22	affinity	affinity	NN
cord-001835-0s7ok4uw	5967	23	for	for	IN
cord-001835-0s7ok4uw	5967	24	Rheb	Rheb	NNP
cord-001835-0s7ok4uw	5967	25	than	than	IN
cord-001835-0s7ok4uw	5967	26	the	the	DT
cord-001835-0s7ok4uw	5967	27	GDP	gdp	NN
cord-001835-0s7ok4uw	5967	28	-	-	HYPH
cord-001835-0s7ok4uw	5967	29	bound	bind	VBN
cord-001835-0s7ok4uw	5967	30	form	form	NN
cord-001835-0s7ok4uw	5968	1	The	the	DT
cord-001835-0s7ok4uw	5968	2	second	second	JJ
cord-001835-0s7ok4uw	5968	3	study	study	NN
cord-001835-0s7ok4uw	5968	4	contradicted	contradict	VBD
cord-001835-0s7ok4uw	5968	5	both	both	DT
cord-001835-0s7ok4uw	5968	6	studies	study	NNS
cord-001835-0s7ok4uw	5968	7	,	,	,
cord-001835-0s7ok4uw	5968	8	since	since	IN
cord-001835-0s7ok4uw	5968	9	they	-PRON-	PRP
cord-001835-0s7ok4uw	5968	10	could	could	MD
cord-001835-0s7ok4uw	5968	11	not	not	RB
cord-001835-0s7ok4uw	5968	12	detect	detect	VB
cord-001835-0s7ok4uw	5968	13	any	any	DT
cord-001835-0s7ok4uw	5968	14	interaction	interaction	NN
cord-001835-0s7ok4uw	5968	15	between	between	IN
cord-001835-0s7ok4uw	5968	16	Rheb	Rheb	NNP
cord-001835-0s7ok4uw	5968	17	and	and	CC
cord-001835-0s7ok4uw	5968	18	FKBP38	FKBP38	NNP
cord-001835-0s7ok4uw	5968	19	[	[	-LRB-
cord-001835-0s7ok4uw	5968	20	8	8	CD
cord-001835-0s7ok4uw	5968	21	]	]	-RRB-
cord-001835-0s7ok4uw	5968	22	.	.	.
cord-001835-0s7ok4uw	5969	1	To	to	TO
cord-001835-0s7ok4uw	5969	2	clarify	clarify	VB
cord-001835-0s7ok4uw	5969	3	whether	whether	IN
cord-001835-0s7ok4uw	5969	4	there	there	EX
cord-001835-0s7ok4uw	5969	5	is	be	VBZ
cord-001835-0s7ok4uw	5969	6	an	an	DT
cord-001835-0s7ok4uw	5969	7	interaction	interaction	NN
cord-001835-0s7ok4uw	5969	8	and	and	CC
cord-001835-0s7ok4uw	5969	9	if	if	IN
cord-001835-0s7ok4uw	5969	10	it	-PRON-	PRP
cord-001835-0s7ok4uw	5969	11	is	be	VBZ
cord-001835-0s7ok4uw	5969	12	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	5969	13	dependent	dependent	JJ
cord-001835-0s7ok4uw	5969	14	,	,	,
cord-001835-0s7ok4uw	5969	15	NMR	NMR	NNP
cord-001835-0s7ok4uw	5969	16	monitored	monitor	VBD
cord-001835-0s7ok4uw	5969	17	interaction	interaction	NN
cord-001835-0s7ok4uw	5969	18	studies	study	NNS
cord-001835-0s7ok4uw	5969	19	were	be	VBD
cord-001835-0s7ok4uw	5969	20	performed	perform	VBN
cord-001835-0s7ok4uw	5969	21	employing	employ	VBG
cord-001835-0s7ok4uw	5969	22	a	a	DT
cord-001835-0s7ok4uw	5969	23	C	c	NN
cord-001835-0s7ok4uw	5969	24	-	-	HYPH
cord-001835-0s7ok4uw	5969	25	terminal	terminal	NN
cord-001835-0s7ok4uw	5969	26	truncated	truncated	JJ
cord-001835-0s7ok4uw	5969	27	construct	construct	NN
cord-001835-0s7ok4uw	5969	28	of	of	IN
cord-001835-0s7ok4uw	5969	29	human	human	JJ
cord-001835-0s7ok4uw	5969	30	Rheb	Rheb	NNP
cord-001835-0s7ok4uw	5969	31	(	(	-LRB-
cord-001835-0s7ok4uw	5969	32	1	1	CD
cord-001835-0s7ok4uw	5969	33	-	-	SYM
cord-001835-0s7ok4uw	5969	34	170	170	CD
cord-001835-0s7ok4uw	5969	35	5	5	CD
cord-001835-0s7ok4uw	5969	36	RhebDCT	rhebdct	NN
cord-001835-0s7ok4uw	5969	37	)	)	-RRB-
cord-001835-0s7ok4uw	5969	38	that	that	WDT
cord-001835-0s7ok4uw	5969	39	can	can	MD
cord-001835-0s7ok4uw	5969	40	not	not	RB
cord-001835-0s7ok4uw	5969	41	be	be	VB
cord-001835-0s7ok4uw	5969	42	farnesylated	farnesylate	VBN
cord-001835-0s7ok4uw	5969	43	and	and	CC
cord-001835-0s7ok4uw	5969	44	the	the	DT
cord-001835-0s7ok4uw	5969	45	biochemically	biochemically	RB
cord-001835-0s7ok4uw	5969	46	defined	define	VBN
cord-001835-0s7ok4uw	5969	47	binding	bind	VBG
cord-001835-0s7ok4uw	5969	48	region	region	NN
cord-001835-0s7ok4uw	5969	49	on	on	IN
cord-001835-0s7ok4uw	5969	50	FKPB38	FKPB38	NNP
cord-001835-0s7ok4uw	5970	1	(	(	-LRB-
cord-001835-0s7ok4uw	5970	2	FKBP12-like	FKBP12-like	NNP
cord-001835-0s7ok4uw	5970	3	5	5	CD
cord-001835-0s7ok4uw	5970	4	FKBP38-BD	FKBP38-BD	NNP
cord-001835-0s7ok4uw	5970	5	)	)	-RRB-
cord-001835-0s7ok4uw	5970	6	.	.	.
cord-001835-0s7ok4uw	5971	1	Based	base	VBN
cord-001835-0s7ok4uw	5971	2	on	on	IN
cord-001835-0s7ok4uw	5971	3	our	-PRON-	PRP$
cord-001835-0s7ok4uw	5971	4	data	datum	NNS
cord-001835-0s7ok4uw	5971	5	RhebDCT	rhebdct	NN
cord-001835-0s7ok4uw	5971	6	-GDP	-GDP	:
cord-001835-0s7ok4uw	5971	7	does	do	VBZ
cord-001835-0s7ok4uw	5971	8	not	not	RB
cord-001835-0s7ok4uw	5971	9	significantly	significantly	RB
cord-001835-0s7ok4uw	5971	10	interact	interact	VB
cord-001835-0s7ok4uw	5971	11	with	with	IN
cord-001835-0s7ok4uw	5971	12	FKBP38-BP	FKBP38-BP	NNP
cord-001835-0s7ok4uw	5971	13	.	.	.
cord-001835-0s7ok4uw	5972	1	15N	15N	NNP
cord-001835-0s7ok4uw	5972	2	-	-	HYPH
cord-001835-0s7ok4uw	5972	3	FKBP38-BD	FKBP38-BD	NNP
cord-001835-0s7ok4uw	5972	4	titrated	titrate	VBD
cord-001835-0s7ok4uw	5972	5	,	,	,
cord-001835-0s7ok4uw	5972	6	we	-PRON-	PRP
cord-001835-0s7ok4uw	5972	7	observed	observe	VBD
cord-001835-0s7ok4uw	5972	8	a	a	DT
cord-001835-0s7ok4uw	5972	9	weak	weak	JJ
cord-001835-0s7ok4uw	5972	10	interaction	interaction	NN
cord-001835-0s7ok4uw	5972	11	between	between	IN
cord-001835-0s7ok4uw	5972	12	RhebDCT	RhebDCT	.
cord-001835-0s7ok4uw	5972	13	bound	bind	VBN
cord-001835-0s7ok4uw	5972	14	to	to	IN
cord-001835-0s7ok4uw	5972	15	a	a	DT
cord-001835-0s7ok4uw	5972	16	GTPanalogon	GTPanalogon	NNP
cord-001835-0s7ok4uw	5972	17	(	(	-LRB-
cord-001835-0s7ok4uw	5972	18	GppNHp	GppNHp	NNP
cord-001835-0s7ok4uw	5972	19	)	)	-RRB-
cord-001835-0s7ok4uw	5972	20	and	and	CC
cord-001835-0s7ok4uw	5972	21	FKBP38-BD	FKBP38-BD	NNP
cord-001835-0s7ok4uw	5972	22	.	.	.
cord-001835-0s7ok4uw	5973	1	Mapping	mapping	NN
cord-001835-0s7ok4uw	5973	2	of	of	IN
cord-001835-0s7ok4uw	5973	3	the	the	DT
cord-001835-0s7ok4uw	5973	4	observed	observed	JJ
cord-001835-0s7ok4uw	5973	5	spectral	spectral	JJ
cord-001835-0s7ok4uw	5973	6	changes	change	NNS
cord-001835-0s7ok4uw	5973	7	on	on	IN
cord-001835-0s7ok4uw	5973	8	the	the	DT
cord-001835-0s7ok4uw	5973	9	structure	structure	NN
cord-001835-0s7ok4uw	5973	10	of	of	IN
cord-001835-0s7ok4uw	5973	11	Rheb	Rheb	NNP
cord-001835-0s7ok4uw	5973	12	-	-	HYPH
cord-001835-0s7ok4uw	5973	13	GTP	GTP	NNP
cord-001835-0s7ok4uw	5973	14	suggests	suggest	VBZ
cord-001835-0s7ok4uw	5973	15	that	that	IN
cord-001835-0s7ok4uw	5973	16	FKBP38	FKBP38	NNP
cord-001835-0s7ok4uw	5973	17	targets	target	VBZ
cord-001835-0s7ok4uw	5973	18	the	the	DT
cord-001835-0s7ok4uw	5973	19	switch	switch	NN
cord-001835-0s7ok4uw	5973	20	2	2	CD
cord-001835-0s7ok4uw	5973	21	region	region	NN
cord-001835-0s7ok4uw	5973	22	,	,	,
cord-001835-0s7ok4uw	5973	23	loop	loop	NN
cord-001835-0s7ok4uw	5973	24	109	109	CD
cord-001835-0s7ok4uw	5973	25	-	-	SYM
cord-001835-0s7ok4uw	5973	26	112	112	CD
cord-001835-0s7ok4uw	5973	27	and	and	CC
cord-001835-0s7ok4uw	5973	28	the	the	DT
cord-001835-0s7ok4uw	5973	29	neighboring	neighboring	NN
cord-001835-0s7ok4uw	5973	30	b	b	NN
cord-001835-0s7ok4uw	5973	31	-	-	HYPH
cord-001835-0s7ok4uw	5973	32	sheet	sheet	NN
cord-001835-0s7ok4uw	5973	33	region	region	NN
cord-001835-0s7ok4uw	5973	34	.	.	.
cord-001835-0s7ok4uw	5974	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5974	2	further	further	RB
cord-001835-0s7ok4uw	5974	3	analyzed	analyze	VBD
cord-001835-0s7ok4uw	5974	4	the	the	DT
cord-001835-0s7ok4uw	5974	5	backbone	backbone	NN
cord-001835-0s7ok4uw	5974	6	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	5974	7	of	of	IN
cord-001835-0s7ok4uw	5974	8	RhebDCT	rhebdct	NN
cord-001835-0s7ok4uw	5974	9	-GDP	-gdp	ADD
cord-001835-0s7ok4uw	5974	10	and	and	CC
cord-001835-0s7ok4uw	5974	11	-GppNHp	-GppNHp	:
cord-001835-0s7ok4uw	5974	12	using	use	VBG
cord-001835-0s7ok4uw	5974	13	15N	15N	NNP
cord-001835-0s7ok4uw	5974	14	relaxtion	relaxtion	NNP
cord-001835-0s7ok4uw	5974	15	data	data	NNP
cord-001835-0s7ok4uw	5974	16	(	(	-LRB-
cord-001835-0s7ok4uw	5974	17	T1	T1	NNP
cord-001835-0s7ok4uw	5974	18	,	,	,
cord-001835-0s7ok4uw	5974	19	T2	T2	NNP
cord-001835-0s7ok4uw	5974	20	and	and	CC
cord-001835-0s7ok4uw	5974	21	heteronuclear	heteronuclear	NNP
cord-001835-0s7ok4uw	5974	22	NOE	NOE	NNP
cord-001835-0s7ok4uw	5974	23	)	)	-RRB-
cord-001835-0s7ok4uw	5974	24	.Based	.base	VBD
cord-001835-0s7ok4uw	5974	25	on	on	IN
cord-001835-0s7ok4uw	5974	26	these	these	DT
cord-001835-0s7ok4uw	5974	27	data	datum	NNS
cord-001835-0s7ok4uw	5975	1	the	the	DT
cord-001835-0s7ok4uw	5975	2	phosphorylation	phosphorylation	NN
cord-001835-0s7ok4uw	5975	3	loop	loop	NN
cord-001835-0s7ok4uw	5975	4	,	,	,
cord-001835-0s7ok4uw	5975	5	the	the	DT
cord-001835-0s7ok4uw	5975	6	switch	switch	NN
cord-001835-0s7ok4uw	5975	7	regions	region	NNS
cord-001835-0s7ok4uw	5975	8	and	and	CC
cord-001835-0s7ok4uw	5975	9	the	the	DT
cord-001835-0s7ok4uw	5975	10	loop	loop	NN
cord-001835-0s7ok4uw	5975	11	around	around	IN
cord-001835-0s7ok4uw	5975	12	residues	residue	NNS
cord-001835-0s7ok4uw	5975	13	109	109	CD
cord-001835-0s7ok4uw	5975	14	-	-	SYM
cord-001835-0s7ok4uw	5975	15	112	112	CD
cord-001835-0s7ok4uw	5975	16	show	show	NN
cord-001835-0s7ok4uw	5975	17	increased	increase	VBN
cord-001835-0s7ok4uw	5975	18	backbone	backbone	NN
cord-001835-0s7ok4uw	5975	19	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	5975	20	that	that	WDT
cord-001835-0s7ok4uw	5975	21	modulated	modulate	VBN
cord-001835-0s7ok4uw	5975	22	by	by	IN
cord-001835-0s7ok4uw	5975	23	the	the	DT
cord-001835-0s7ok4uw	5975	24	nucleotide	nucleotide	JJ
cord-001835-0s7ok4uw	5975	25	binding	bind	VBG
cord-001835-0s7ok4uw	5976	1	5	5	CD
cord-001835-0s7ok4uw	5976	2	International	International	NNP
cord-001835-0s7ok4uw	5976	3	Centre	Centre	NNP
cord-001835-0s7ok4uw	5976	4	for	for	IN
cord-001835-0s7ok4uw	5976	5	Genetic	Genetic	NNP
cord-001835-0s7ok4uw	5976	6	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	5976	7	and	and	CC
cord-001835-0s7ok4uw	5976	8	Biotechnology	Biotechnology	NNP
cord-001835-0s7ok4uw	5976	9	TDP-43	TDP-43	NNP
cord-001835-0s7ok4uw	5976	10	is	be	VBZ
cord-001835-0s7ok4uw	5976	11	an	an	DT
cord-001835-0s7ok4uw	5976	12	RNA	RNA	NNP
cord-001835-0s7ok4uw	5976	13	processing	processing	NN
cord-001835-0s7ok4uw	5976	14	protein	protein	NN
cord-001835-0s7ok4uw	5976	15	that	that	WDT
cord-001835-0s7ok4uw	5976	16	can	can	MD
cord-001835-0s7ok4uw	5976	17	form	form	VB
cord-001835-0s7ok4uw	5976	18	inclusions	inclusion	NNS
cord-001835-0s7ok4uw	5976	19	of	of	IN
cord-001835-0s7ok4uw	5976	20	debatable	debatable	JJ
cord-001835-0s7ok4uw	5976	21	nature	nature	NN
cord-001835-0s7ok4uw	5976	22	implicated	implicate	VBN
cord-001835-0s7ok4uw	5976	23	in	in	IN
cord-001835-0s7ok4uw	5976	24	neurodegenerative	neurodegenerative	JJ
cord-001835-0s7ok4uw	5976	25	diseases	disease	NNS
cord-001835-0s7ok4uw	5976	26	.	.	.
cord-001835-0s7ok4uw	5977	1	Within	within	IN
cord-001835-0s7ok4uw	5977	2	the	the	DT
cord-001835-0s7ok4uw	5977	3	putative	putative	JJ
cord-001835-0s7ok4uw	5977	4	aggregation	aggregation	NN
cord-001835-0s7ok4uw	5977	5	domain	domain	NN
cord-001835-0s7ok4uw	5977	6	,	,	,
cord-001835-0s7ok4uw	5977	7	repeats	repeat	VBZ
cord-001835-0s7ok4uw	5977	8	of	of	IN
cord-001835-0s7ok4uw	5977	9	residues	residue	NNS
cord-001835-0s7ok4uw	5977	10	341	341	CD
cord-001835-0s7ok4uw	5977	11	-	-	SYM
cord-001835-0s7ok4uw	5977	12	366	366	CD
cord-001835-0s7ok4uw	5977	13	can	can	MD
cord-001835-0s7ok4uw	5977	14	recruit	recruit	VB
cord-001835-0s7ok4uw	5977	15	endogenous	endogenous	JJ
cord-001835-0s7ok4uw	5977	16	TDP-43	TDP-43	NNP
cord-001835-0s7ok4uw	5977	17	into	into	IN
cord-001835-0s7ok4uw	5977	18	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	5977	19	inside	inside	IN
cord-001835-0s7ok4uw	5977	20	cells1	cells1	NN
cord-001835-0s7ok4uw	5977	21	.	.	.
cord-001835-0s7ok4uw	5978	1	Recently	recently	RB
cord-001835-0s7ok4uw	5978	2	,	,	,
cord-001835-0s7ok4uw	5978	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	5978	4	showed	show	VBD
cord-001835-0s7ok4uw	5978	5	that	that	IN
cord-001835-0s7ok4uw	5978	6	a	a	DT
cord-001835-0s7ok4uw	5978	7	coil	coil	NN
cord-001835-0s7ok4uw	5978	8	to	to	IN
cord-001835-0s7ok4uw	5978	9	b	b	NN
cord-001835-0s7ok4uw	5978	10	-	-	HYPH
cord-001835-0s7ok4uw	5978	11	hairpin	hairpin	NN
cord-001835-0s7ok4uw	5978	12	transition	transition	NN
cord-001835-0s7ok4uw	5978	13	in	in	IN
cord-001835-0s7ok4uw	5978	14	a	a	DT
cord-001835-0s7ok4uw	5978	15	short	short	JJ
cord-001835-0s7ok4uw	5978	16	peptide	peptide	NN
cord-001835-0s7ok4uw	5978	17	corresponding	correspond	VBG
cord-001835-0s7ok4uw	5978	18	to	to	IN
cord-001835-0s7ok4uw	5978	19	TDP-43	tdp-43	JJ
cord-001835-0s7ok4uw	5978	20	residues	residue	NNS
cord-001835-0s7ok4uw	5978	21	341	341	CD
cord-001835-0s7ok4uw	5978	22	-	-	SYM
cord-001835-0s7ok4uw	5978	23	357	357	CD
cord-001835-0s7ok4uw	5978	24	enables	enable	VBZ
cord-001835-0s7ok4uw	5978	25	oligomerization2	oligomerization2	NN
cord-001835-0s7ok4uw	5978	26	.	.	.
cord-001835-0s7ok4uw	5979	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5979	2	have	have	VBP
cord-001835-0s7ok4uw	5979	3	used	use	VBN
cord-001835-0s7ok4uw	5979	4	a	a	DT
cord-001835-0s7ok4uw	5979	5	broad	broad	JJ
cord-001835-0s7ok4uw	5979	6	battery	battery	NN
cord-001835-0s7ok4uw	5979	7	of	of	IN
cord-001835-0s7ok4uw	5979	8	biophysical	biophysical	JJ
cord-001835-0s7ok4uw	5979	9	experiments	experiment	NNS
cord-001835-0s7ok4uw	5979	10	,	,	,
cord-001835-0s7ok4uw	5979	11	including	include	VBG
cord-001835-0s7ok4uw	5979	12	chromophore	chromophore	NN
cord-001835-0s7ok4uw	5979	13	and	and	CC
cord-001835-0s7ok4uw	5979	14	antibody	antibody	NN
cord-001835-0s7ok4uw	5979	15	binding	binding	NN
cord-001835-0s7ok4uw	5979	16	,	,	,
cord-001835-0s7ok4uw	5979	17	electron	electron	NN
cord-001835-0s7ok4uw	5979	18	microscopy	microscopy	NN
cord-001835-0s7ok4uw	5979	19	(	(	-LRB-
cord-001835-0s7ok4uw	5979	20	EM	EM	NNP
cord-001835-0s7ok4uw	5979	21	)	)	-RRB-
cord-001835-0s7ok4uw	5979	22	,	,	,
cord-001835-0s7ok4uw	5979	23	circular	circular	JJ
cord-001835-0s7ok4uw	5979	24	dichroism	dichroism	NN
cord-001835-0s7ok4uw	5979	25	(	(	-LRB-
cord-001835-0s7ok4uw	5979	26	CD	CD	NNP
cord-001835-0s7ok4uw	5979	27	)	)	-RRB-
cord-001835-0s7ok4uw	5979	28	,	,	,
cord-001835-0s7ok4uw	5979	29	solution	solution	NN
cord-001835-0s7ok4uw	5979	30	and	and	CC
cord-001835-0s7ok4uw	5979	31	solid	solid	JJ
cord-001835-0s7ok4uw	5979	32	-	-	HYPH
cord-001835-0s7ok4uw	5979	33	state	state	NN
cord-001835-0s7ok4uw	5979	34	NMR	nmr	NN
cord-001835-0s7ok4uw	5979	35	,	,	,
cord-001835-0s7ok4uw	5979	36	and	and	CC
cord-001835-0s7ok4uw	5979	37	X	x	NN
cord-001835-0s7ok4uw	5979	38	-	-	NN
cord-001835-0s7ok4uw	5979	39	ray	ray	NN
cord-001835-0s7ok4uw	5979	40	to	to	TO
cord-001835-0s7ok4uw	5979	41	shed	shed	VB
cord-001835-0s7ok4uw	5979	42	light	light	NN
cord-001835-0s7ok4uw	5979	43	on	on	IN
cord-001835-0s7ok4uw	5979	44	the	the	DT
cord-001835-0s7ok4uw	5979	45	nature	nature	NN
cord-001835-0s7ok4uw	5979	46	of	of	IN
cord-001835-0s7ok4uw	5979	47	these	these	DT
cord-001835-0s7ok4uw	5979	48	aggregates	aggregate	NNS
cord-001835-0s7ok4uw	5979	49	.	.	.
cord-001835-0s7ok4uw	5980	1	Based	base	VBN
cord-001835-0s7ok4uw	5980	2	on	on	IN
cord-001835-0s7ok4uw	5980	3	these	these	DT
cord-001835-0s7ok4uw	5980	4	findings	finding	NNS
cord-001835-0s7ok4uw	5980	5	,	,	,
cord-001835-0s7ok4uw	5980	6	structural	structural	JJ
cord-001835-0s7ok4uw	5980	7	models	model	NNS
cord-001835-0s7ok4uw	5980	8	for	for	IN
cord-001835-0s7ok4uw	5980	9	TDP-43(341	TDP-43(341	NNP
cord-001835-0s7ok4uw	5980	10	-	-	HYPH
cord-001835-0s7ok4uw	5980	11	357	357	CD
cord-001835-0s7ok4uw	5980	12	)	)	-RRB-
cord-001835-0s7ok4uw	5980	13	oligomers	oligomer	NNS
cord-001835-0s7ok4uw	5980	14	have	have	VBP
cord-001835-0s7ok4uw	5980	15	been	be	VBN
cord-001835-0s7ok4uw	5980	16	constructed	construct	VBN
cord-001835-0s7ok4uw	5980	17	,	,	,
cord-001835-0s7ok4uw	5980	18	refined	refine	VBN
cord-001835-0s7ok4uw	5980	19	,	,	,
cord-001835-0s7ok4uw	5980	20	verified	verify	VBN
cord-001835-0s7ok4uw	5980	21	,	,	,
cord-001835-0s7ok4uw	5980	22	and	and	CC
cord-001835-0s7ok4uw	5980	23	analyzed	analyze	VBD
cord-001835-0s7ok4uw	5980	24	using	use	VBG
cord-001835-0s7ok4uw	5980	25	computational	computational	JJ
cord-001835-0s7ok4uw	5980	26	methods	method	NNS
cord-001835-0s7ok4uw	5980	27	,	,	,
cord-001835-0s7ok4uw	5980	28	ranging	range	VBG
cord-001835-0s7ok4uw	5980	29	from	from	IN
cord-001835-0s7ok4uw	5980	30	Docking	Docking	NNP
cord-001835-0s7ok4uw	5980	31	and	and	CC
cord-001835-0s7ok4uw	5980	32	Molecular	Molecular	NNP
cord-001835-0s7ok4uw	5980	33	Dynamics	Dynamics	NNP
cord-001835-0s7ok4uw	5980	34	simulations	simulation	NNS
cord-001835-0s7ok4uw	5980	35	to	to	IN
cord-001835-0s7ok4uw	5980	36	Semiempirical	Semiempirical	NNP
cord-001835-0s7ok4uw	5980	37	Quantum	Quantum	NNP
cord-001835-0s7ok4uw	5980	38	Mechanics	Mechanics	NNPS
cord-001835-0s7ok4uw	5980	39	calculations	calculation	NNS
cord-001835-0s7ok4uw	5980	40	.	.	.
cord-001835-0s7ok4uw	5981	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	5981	2	,	,	,
cord-001835-0s7ok4uw	5981	3	TDP-43(341	TDP-43(341	NNP
cord-001835-0s7ok4uw	5981	4	-	-	HYPH
cord-001835-0s7ok4uw	5981	5	357	357	CD
cord-001835-0s7ok4uw	5981	6	)	)	-RRB-
cord-001835-0s7ok4uw	5981	7	b	b	NN
cord-001835-0s7ok4uw	5981	8	-	-	HYPH
cord-001835-0s7ok4uw	5981	9	hairpins	hairpin	NNS
cord-001835-0s7ok4uw	5981	10	assemble	assemble	VBP
cord-001835-0s7ok4uw	5981	11	into	into	IN
cord-001835-0s7ok4uw	5981	12	a	a	DT
cord-001835-0s7ok4uw	5981	13	novel	novel	JJ
cord-001835-0s7ok4uw	5981	14	parallel	parallel	NN
cord-001835-0s7ok4uw	5981	15	b	b	NN
cord-001835-0s7ok4uw	5981	16	-	-	HYPH
cord-001835-0s7ok4uw	5981	17	turn	turn	NN
cord-001835-0s7ok4uw	5981	18	configuration	configuration	NN
cord-001835-0s7ok4uw	5981	19	showing	show	VBG
cord-001835-0s7ok4uw	5981	20	crossb	crossb	NN
cord-001835-0s7ok4uw	5981	21	spine	spine	NN
cord-001835-0s7ok4uw	5981	22	,	,	,
cord-001835-0s7ok4uw	5981	23	cooperative	cooperative	JJ
cord-001835-0s7ok4uw	5981	24	H	h	NN
cord-001835-0s7ok4uw	5981	25	-	-	HYPH
cord-001835-0s7ok4uw	5981	26	bonding	bonding	NN
cord-001835-0s7ok4uw	5981	27	and	and	CC
cord-001835-0s7ok4uw	5981	28	tight	tight	JJ
cord-001835-0s7ok4uw	5981	29	side	side	NN
cord-001835-0s7ok4uw	5981	30	chain	chain	NN
cord-001835-0s7ok4uw	5981	31	packing3	packing3	NN
cord-001835-0s7ok4uw	5981	32	Cellular	Cellular	NNP
cord-001835-0s7ok4uw	5981	33	Model	Model	NNP
cord-001835-0s7ok4uw	5981	34	of	of	IN
cord-001835-0s7ok4uw	5981	35	TAR	TAR	NNP
cord-001835-0s7ok4uw	5981	36	DNA	dna	NN
cord-001835-0s7ok4uw	5981	37	-	-	HYPH
cord-001835-0s7ok4uw	5981	38	Binding	bind	VBG
cord-001835-0s7ok4uw	5981	39	Protein	Protein	NNP
cord-001835-0s7ok4uw	5981	40	43(TDP-43	43(tdp-43	CD
cord-001835-0s7ok4uw	5981	41	)	)	-RRB-
cord-001835-0s7ok4uw	5981	42	Aggregation	aggregation	NN
cord-001835-0s7ok4uw	5981	43	Based	base	VBN
cord-001835-0s7ok4uw	5981	44	on	on	IN
cord-001835-0s7ok4uw	5981	45	Its	-PRON-	PRP$
cord-001835-0s7ok4uw	5981	46	C	C	NNP
cord-001835-0s7ok4uw	5981	47	-	-	HYPH
cord-001835-0s7ok4uw	5981	48	Terminal	Terminal	NNP
cord-001835-0s7ok4uw	5981	49	Gln	Gln	NNP
cord-001835-0s7ok4uw	5981	50	/	/	SYM
cord-001835-0s7ok4uw	5981	51	Asn	Asn	NNP
cord-001835-0s7ok4uw	5981	52	-	-	HYPH
cord-001835-0s7ok4uw	5981	53	Rich	Rich	NNP
cord-001835-0s7ok4uw	5981	54	Region	Region	NNP
cord-001835-0s7ok4uw	5981	55	Structural	structural	JJ
cord-001835-0s7ok4uw	5981	56	Characterization	characterization	NN
cord-001835-0s7ok4uw	5981	57	of	of	IN
cord-001835-0s7ok4uw	5981	58	the	the	DT
cord-001835-0s7ok4uw	5981	59	Minimal	Minimal	NNP
cord-001835-0s7ok4uw	5981	60	Segment	Segment	NNP
cord-001835-0s7ok4uw	5981	61	of	of	IN
cord-001835-0s7ok4uw	5981	62	TDP-43	TDP-43	NNP
cord-001835-0s7ok4uw	5981	63	Competent	Competent	NNP
cord-001835-0s7ok4uw	5981	64	for	for	IN
cord-001835-0s7ok4uw	5981	65	Aggregation	aggregation	NN
cord-001835-0s7ok4uw	5981	66	Structural	structural	JJ
cord-001835-0s7ok4uw	5981	67	Evidence	evidence	NN
cord-001835-0s7ok4uw	5981	68	of	of	IN
cord-001835-0s7ok4uw	5981	69	Amyloid	Amyloid	NNP
cord-001835-0s7ok4uw	5981	70	Fibril	Fibril	NNP
cord-001835-0s7ok4uw	5981	71	Formation	Formation	NNP
cord-001835-0s7ok4uw	5981	72	in	in	IN
cord-001835-0s7ok4uw	5981	73	the	the	DT
cord-001835-0s7ok4uw	5981	74	Putative	Putative	NNP
cord-001835-0s7ok4uw	5981	75	Aggregation	Aggregation	NNP
cord-001835-0s7ok4uw	5981	76	Domain	Domain	NNP
cord-001835-0s7ok4uw	5981	77	of	of	IN
cord-001835-0s7ok4uw	5981	78	TDP-43	TDP-43	NNP
cord-001835-0s7ok4uw	5981	79	Kyungpook	Kyungpook	NNP
cord-001835-0s7ok4uw	5981	80	National	National	NNP
cord-001835-0s7ok4uw	5981	81	University	University	NNP
cord-001835-0s7ok4uw	5981	82	Scolopendin	Scolopendin	NNP
cord-001835-0s7ok4uw	5981	83	2	2	CD
cord-001835-0s7ok4uw	5981	84	,	,	,
cord-001835-0s7ok4uw	5981	85	AGLQFPVGRIGRLLRK	AGLQFPVGRIGRLLRK	NNP
cord-001835-0s7ok4uw	5981	86	,	,	,
cord-001835-0s7ok4uw	5981	87	is	be	VBZ
cord-001835-0s7ok4uw	5981	88	a	a	DT
cord-001835-0s7ok4uw	5981	89	16-mer	16-mer	CD
cord-001835-0s7ok4uw	5981	90	peptide	peptide	NN
cord-001835-0s7ok4uw	5981	91	derived	derive	VBN
cord-001835-0s7ok4uw	5981	92	from	from	IN
cord-001835-0s7ok4uw	5981	93	the	the	DT
cord-001835-0s7ok4uw	5981	94	centipede	centipede	NN
cord-001835-0s7ok4uw	5981	95	Scolopendra	Scolopendra	NNP
cord-001835-0s7ok4uw	5981	96	subspinipes	subspinipes	NNP
cord-001835-0s7ok4uw	5981	97	mutilans	mutilans	NNP
cord-001835-0s7ok4uw	5981	98	.	.	.
cord-001835-0s7ok4uw	5982	1	To	to	TO
cord-001835-0s7ok4uw	5982	2	investigate	investigate	VB
cord-001835-0s7ok4uw	5982	3	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5982	4	property	property	NN
cord-001835-0s7ok4uw	5982	5	against	against	IN
cord-001835-0s7ok4uw	5982	6	fungal	fungal	NN
cord-001835-0s7ok4uw	5982	7	and	and	CC
cord-001835-0s7ok4uw	5982	8	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5982	9	pathogens	pathogen	NNS
cord-001835-0s7ok4uw	5982	10	,	,	,
cord-001835-0s7ok4uw	5982	11	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5982	12	tests	test	NNS
cord-001835-0s7ok4uw	5982	13	were	be	VBD
cord-001835-0s7ok4uw	5982	14	performed	perform	VBN
cord-001835-0s7ok4uw	5982	15	.	.	.
cord-001835-0s7ok4uw	5983	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5983	2	observed	observe	VBD
cord-001835-0s7ok4uw	5983	3	that	that	IN
cord-001835-0s7ok4uw	5983	4	this	this	DT
cord-001835-0s7ok4uw	5983	5	peptide	peptide	NN
cord-001835-0s7ok4uw	5983	6	exhibited	exhibit	VBD
cord-001835-0s7ok4uw	5983	7	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5983	8	activity	activity	NN
cord-001835-0s7ok4uw	5983	9	in	in	IN
cord-001835-0s7ok4uw	5983	10	a	a	DT
cord-001835-0s7ok4uw	5983	11	salt	salt	NN
cord-001835-0s7ok4uw	5983	12	-	-	HYPH
cord-001835-0s7ok4uw	5983	13	dependent	dependent	JJ
cord-001835-0s7ok4uw	5983	14	manner	manner	NN
cord-001835-0s7ok4uw	5983	15	and	and	CC
cord-001835-0s7ok4uw	5983	16	showed	show	VBD
cord-001835-0s7ok4uw	5983	17	no	no	DT
cord-001835-0s7ok4uw	5983	18	hemolysis	hemolysis	NN
cord-001835-0s7ok4uw	5983	19	.	.	.
cord-001835-0s7ok4uw	5984	1	The	the	DT
cord-001835-0s7ok4uw	5984	2	circular	circular	JJ
cord-001835-0s7ok4uw	5984	3	dichroism	dichroism	NN
cord-001835-0s7ok4uw	5984	4	(	(	-LRB-
cord-001835-0s7ok4uw	5984	5	CD	CD	NNP
cord-001835-0s7ok4uw	5984	6	)	)	-RRB-
cord-001835-0s7ok4uw	5984	7	analysis	analysis	NN
cord-001835-0s7ok4uw	5984	8	observed	observe	VBD
cord-001835-0s7ok4uw	5984	9	that	that	IN
cord-001835-0s7ok4uw	5984	10	a	a	DT
cord-001835-0s7ok4uw	5984	11	-	-	HYPH
cord-001835-0s7ok4uw	5984	12	helical	helical	JJ
cord-001835-0s7ok4uw	5984	13	structure	structure	NN
cord-001835-0s7ok4uw	5984	14	properties	property	NNS
cord-001835-0s7ok4uw	5984	15	.	.	.
cord-001835-0s7ok4uw	5985	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	5985	2	determined	determine	VBD
cord-001835-0s7ok4uw	5985	3	the	the	DT
cord-001835-0s7ok4uw	5985	4	mechanism(s	mechanism(s	NNP
cord-001835-0s7ok4uw	5985	5	)	)	-RRB-
cord-001835-0s7ok4uw	5985	6	of	of	IN
cord-001835-0s7ok4uw	5985	7	action	action	NN
cord-001835-0s7ok4uw	5985	8	using	use	VBG
cord-001835-0s7ok4uw	5985	9	flow	flow	NN
cord-001835-0s7ok4uw	5985	10	cytometry	cytometry	NN
cord-001835-0s7ok4uw	5985	11	and	and	CC
cord-001835-0s7ok4uw	5985	12	investigated	investigate	VBD
cord-001835-0s7ok4uw	5985	13	the	the	DT
cord-001835-0s7ok4uw	5985	14	release	release	NN
cord-001835-0s7ok4uw	5985	15	of	of	IN
cord-001835-0s7ok4uw	5985	16	potassium	potassium	NN
cord-001835-0s7ok4uw	5985	17	.	.	.
cord-001835-0s7ok4uw	5986	1	The	the	DT
cord-001835-0s7ok4uw	5986	2	results	result	NNS
cord-001835-0s7ok4uw	5986	3	showed	show	VBD
cord-001835-0s7ok4uw	5986	4	that	that	IN
cord-001835-0s7ok4uw	5986	5	the	the	DT
cord-001835-0s7ok4uw	5986	6	microbial	microbial	JJ
cord-001835-0s7ok4uw	5986	7	membrane	membrane	NN
cord-001835-0s7ok4uw	5986	8	in	in	IN
cord-001835-0s7ok4uw	5986	9	Escherichia	Escherichia	NNP
cord-001835-0s7ok4uw	5986	10	coli	coli	NNS
cord-001835-0s7ok4uw	5986	11	O157	O157	NNP
cord-001835-0s7ok4uw	5986	12	and	and	CC
cord-001835-0s7ok4uw	5986	13	Candida	Candida	NNP
cord-001835-0s7ok4uw	5986	14	albicans	albican	NNS
cord-001835-0s7ok4uw	5986	15	was	be	VBD
cord-001835-0s7ok4uw	5986	16	permeabilized	permeabilize	VBN
cord-001835-0s7ok4uw	5986	17	with	with	IN
cord-001835-0s7ok4uw	5986	18	loss	loss	NN
cord-001835-0s7ok4uw	5986	19	of	of	IN
cord-001835-0s7ok4uw	5986	20	potassium	potassium	NN
cord-001835-0s7ok4uw	5986	21	ions	ion	NNS
cord-001835-0s7ok4uw	5986	22	.	.	.
cord-001835-0s7ok4uw	5987	1	Additionally	additionally	RB
cord-001835-0s7ok4uw	5987	2	,	,	,
cord-001835-0s7ok4uw	5987	3	the	the	DT
cord-001835-0s7ok4uw	5987	4	bis-(1,3-dibutylbarbituric	bis-(1,3-dibutylbarbituric	JJ
cord-001835-0s7ok4uw	5987	5	acid	acid	NN
cord-001835-0s7ok4uw	5987	6	)	)	-RRB-
cord-001835-0s7ok4uw	5987	7	trimethine	trimethine	NNP
cord-001835-0s7ok4uw	5987	8	oxonol	oxonol	NNP
cord-001835-0s7ok4uw	5987	9	[	[	-LRB-
cord-001835-0s7ok4uw	5987	10	DiBAC4(3	DiBAC4(3	NNP
cord-001835-0s7ok4uw	5987	11	)	)	-RRB-
cord-001835-0s7ok4uw	5987	12	]	]	-RRB-
cord-001835-0s7ok4uw	5987	13	and	and	CC
cord-001835-0s7ok4uw	5987	14	3,3'-dipropylthiacarbocyanine	3,3'-dipropylthiacarbocyanine	CD
cord-001835-0s7ok4uw	5987	15	iodide	iodide	NN
cord-001835-0s7ok4uw	5987	16	[	[	-LRB-
cord-001835-0s7ok4uw	5987	17	DiSC3	DiSC3	NNP
cord-001835-0s7ok4uw	5987	18	(	(	-LRB-
cord-001835-0s7ok4uw	5987	19	5	5	CD
cord-001835-0s7ok4uw	5987	20	)	)	-RRB-
cord-001835-0s7ok4uw	5987	21	]	]	-RRB-
cord-001835-0s7ok4uw	5988	1	assay	assay	NNP
cord-001835-0s7ok4uw	5988	2	showed	show	VBD
cord-001835-0s7ok4uw	5988	3	membrane	membrane	NN
cord-001835-0s7ok4uw	5988	4	depolarization	depolarization	NN
cord-001835-0s7ok4uw	5988	5	.	.	.
cord-001835-0s7ok4uw	5989	1	Using	use	VBG
cord-001835-0s7ok4uw	5989	2	calcein	calcein	NN
cord-001835-0s7ok4uw	5989	3	-	-	HYPH
cord-001835-0s7ok4uw	5989	4	encapsulating	encapsulate	VBG
cord-001835-0s7ok4uw	5989	5	giant	giant	JJ
cord-001835-0s7ok4uw	5989	6	unilamellar	unilamellar	NNP
cord-001835-0s7ok4uw	5989	7	vesicles	vesicle	NNS
cord-001835-0s7ok4uw	5989	8	(	(	-LRB-
cord-001835-0s7ok4uw	5989	9	GUVs	GUVs	NNP
cord-001835-0s7ok4uw	5989	10	)	)	-RRB-
cord-001835-0s7ok4uw	5989	11	and	and	CC
cord-001835-0s7ok4uw	5989	12	FITC	FITC	NNP
cord-001835-0s7ok4uw	5989	13	-	-	HYPH
cord-001835-0s7ok4uw	5989	14	dextran	dextran	NN
cord-001835-0s7ok4uw	5989	15	containing	contain	VBG
cord-001835-0s7ok4uw	5989	16	large	large	JJ
cord-001835-0s7ok4uw	5989	17	unilamellar	unilamellar	NNP
cord-001835-0s7ok4uw	5989	18	vesicles	vesicle	NNS
cord-001835-0s7ok4uw	5989	19	(	(	-LRB-
cord-001835-0s7ok4uw	5989	20	LUVs	LUVs	NNP
cord-001835-0s7ok4uw	5989	21	)	)	-RRB-
cord-001835-0s7ok4uw	5989	22	,	,	,
cord-001835-0s7ok4uw	5989	23	scolopendin	scolopendin	NNS
cord-001835-0s7ok4uw	5989	24	2	2	CD
cord-001835-0s7ok4uw	5989	25	disrupted	disrupt	VBD
cord-001835-0s7ok4uw	5989	26	the	the	DT
cord-001835-0s7ok4uw	5989	27	cell	cell	NN
cord-001835-0s7ok4uw	5989	28	membrane	membrane	NN
cord-001835-0s7ok4uw	5989	29	and	and	CC
cord-001835-0s7ok4uw	5989	30	the	the	DT
cord-001835-0s7ok4uw	5989	31	damage	damage	NN
cord-001835-0s7ok4uw	5989	32	size	size	NN
cord-001835-0s7ok4uw	5989	33	is	be	VBZ
cord-001835-0s7ok4uw	5989	34	between	between	IN
cord-001835-0s7ok4uw	5989	35	4.8	4.8	CD
cord-001835-0s7ok4uw	5989	36	to	to	TO
cord-001835-0s7ok4uw	5989	37	5.0	5.0	CD
cord-001835-0s7ok4uw	5989	38	nm	nm	NN
cord-001835-0s7ok4uw	5989	39	against	against	IN
cord-001835-0s7ok4uw	5989	40	composition	composition	NN
cord-001835-0s7ok4uw	5989	41	of	of	IN
cord-001835-0s7ok4uw	5989	42	microbial	microbial	JJ
cord-001835-0s7ok4uw	5989	43	plasma	plasma	NN
cord-001835-0s7ok4uw	5989	44	membrane	membrane	NN
cord-001835-0s7ok4uw	5989	45	of	of	IN
cord-001835-0s7ok4uw	5989	46	E.	E.	NNP
cord-001835-0s7ok4uw	5989	47	coli	coli	NNS
cord-001835-0s7ok4uw	5989	48	and	and	CC
cord-001835-0s7ok4uw	5989	49	C.	C.	NNP
cord-001835-0s7ok4uw	5989	50	albicans	albican	NNS
cord-001835-0s7ok4uw	5989	51	.	.	.
cord-001835-0s7ok4uw	5990	1	Thus	thus	RB
cord-001835-0s7ok4uw	5990	2	,	,	,
cord-001835-0s7ok4uw	5990	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	5990	4	demonstrated	demonstrate	VBD
cord-001835-0s7ok4uw	5990	5	that	that	IN
cord-001835-0s7ok4uw	5990	6	a	a	DT
cord-001835-0s7ok4uw	5990	7	cationic	cationic	JJ
cord-001835-0s7ok4uw	5990	8	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5990	9	peptide	peptide	NN
cord-001835-0s7ok4uw	5990	10	,	,	,
cord-001835-0s7ok4uw	5990	11	scolopendin	scolopendin	NNS
cord-001835-0s7ok4uw	5990	12	2	2	CD
cord-001835-0s7ok4uw	5990	13	,	,	,
cord-001835-0s7ok4uw	5990	14	possesses	possess	VBZ
cord-001835-0s7ok4uw	5990	15	broad	broad	JJ
cord-001835-0s7ok4uw	5990	16	-	-	HYPH
cord-001835-0s7ok4uw	5990	17	spectrum	spectrum	NN
cord-001835-0s7ok4uw	5990	18	antimicrobial	antimicrobial	JJ
cord-001835-0s7ok4uw	5990	19	effects	effect	NNS
cord-001835-0s7ok4uw	5990	20	that	that	WDT
cord-001835-0s7ok4uw	5990	21	formed	form	VBD
cord-001835-0s7ok4uw	5990	22	pore	pore	NN
cord-001835-0s7ok4uw	5990	23	on	on	IN
cord-001835-0s7ok4uw	5990	24	the	the	DT
cord-001835-0s7ok4uw	5990	25	cell	cell	NN
cord-001835-0s7ok4uw	5990	26	membrane	membrane	NN
cord-001835-0s7ok4uw	5990	27	.	.	.
cord-001835-0s7ok4uw	5991	1	Structural	structural	JJ
cord-001835-0s7ok4uw	5991	2	and	and	CC
cord-001835-0s7ok4uw	5991	3	functional	functional	JJ
cord-001835-0s7ok4uw	5991	4	investigation	investigation	NN
cord-001835-0s7ok4uw	5991	5	of	of	IN
cord-001835-0s7ok4uw	5991	6	the	the	DT
cord-001835-0s7ok4uw	5991	7	far	far	JJ
cord-001835-0s7ok4uw	5991	8	C	c	NN
cord-001835-0s7ok4uw	5991	9	-	-	HYPH
cord-001835-0s7ok4uw	5991	10	terminal	terminal	NN
cord-001835-0s7ok4uw	5991	11	domain	domain	NN
cord-001835-0s7ok4uw	5991	12	(	(	-LRB-
cord-001835-0s7ok4uw	5991	13	CTD	CTD	NNP
cord-001835-0s7ok4uw	5991	14	)	)	-RRB-
cord-001835-0s7ok4uw	5991	15	of	of	IN
cord-001835-0s7ok4uw	5991	16	the	the	DT
cord-001835-0s7ok4uw	5991	17	bifunctional	bifunctional	JJ
cord-001835-0s7ok4uw	5991	18	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5991	19	traI	traI	VBD
cord-001835-0s7ok4uw	5991	20	using	use	VBG
cord-001835-0s7ok4uw	5991	21	NMR	NMR	NNP
cord-001835-0s7ok4uw	5991	22	Spectroscopy	Spectroscopy	NNP
cord-001835-0s7ok4uw	5991	23	Protein	Protein	NNP
cord-001835-0s7ok4uw	5991	24	Structural	Structural	NNP
cord-001835-0s7ok4uw	5991	25	Biology	Biology	NNP
cord-001835-0s7ok4uw	5991	26	Structural	Structural	NNP
cord-001835-0s7ok4uw	5991	27	and	and	CC
cord-001835-0s7ok4uw	5991	28	functional	functional	JJ
cord-001835-0s7ok4uw	5991	29	investigation	investigation	NN
cord-001835-0s7ok4uw	5991	30	of	of	IN
cord-001835-0s7ok4uw	5991	31	the	the	DT
cord-001835-0s7ok4uw	5991	32	far	far	JJ
cord-001835-0s7ok4uw	5991	33	C	c	NN
cord-001835-0s7ok4uw	5991	34	-	-	HYPH
cord-001835-0s7ok4uw	5991	35	terminal	terminal	NN
cord-001835-0s7ok4uw	5991	36	domain	domain	NN
cord-001835-0s7ok4uw	5991	37	(	(	-LRB-
cord-001835-0s7ok4uw	5991	38	CTD	CTD	NNP
cord-001835-0s7ok4uw	5991	39	)	)	-RRB-
cord-001835-0s7ok4uw	5991	40	of	of	IN
cord-001835-0s7ok4uw	5991	41	the	the	DT
cord-001835-0s7ok4uw	5991	42	bifunctional	bifunctional	JJ
cord-001835-0s7ok4uw	5991	43	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5991	44	TraI	TraI	NNP
cord-001835-0s7ok4uw	5991	45	using	use	VBG
cord-001835-0s7ok4uw	5991	46	NMR	NMR	NNP
cord-001835-0s7ok4uw	5991	47	Spectroscopy	Spectroscopy	NNP
cord-001835-0s7ok4uw	5991	48	B.Krishna	B.Krishna	NNP
cord-001835-0s7ok4uw	5991	49	Chaitanya	Chaitanya	NNP
cord-001835-0s7ok4uw	5991	50	,	,	,
cord-001835-0s7ok4uw	5991	51	Evelyne	Evelyne	NNP
cord-001835-0s7ok4uw	5991	52	Schrank	Schrank	NNP
cord-001835-0s7ok4uw	5991	53	and	and	CC
cord-001835-0s7ok4uw	5991	54	Klaus	Klaus	NNP
cord-001835-0s7ok4uw	5991	55	Zangger	Zangger	NNP
cord-001835-0s7ok4uw	5991	56	Institute	Institute	NNP
cord-001835-0s7ok4uw	5991	57	of	of	IN
cord-001835-0s7ok4uw	5991	58	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	5991	59	/	/	SYM
cord-001835-0s7ok4uw	5991	60	Organic	Organic	NNP
cord-001835-0s7ok4uw	5991	61	and	and	CC
cord-001835-0s7ok4uw	5991	62	Bioorganic	Bioorganic	NNP
cord-001835-0s7ok4uw	5991	63	Chemistry	Chemistry	NNP
cord-001835-0s7ok4uw	5991	64	University	University	NNP
cord-001835-0s7ok4uw	5991	65	of	of	IN
cord-001835-0s7ok4uw	5991	66	Graz	Graz	NNP
cord-001835-0s7ok4uw	5991	67	,	,	,
cord-001835-0s7ok4uw	5992	1	Austria	Austria	NNP
cord-001835-0s7ok4uw	5992	2	Corresponding	correspond	VBG
cord-001835-0s7ok4uw	5992	3	author	author	NN
cord-001835-0s7ok4uw	5992	4	email	email	NN
cord-001835-0s7ok4uw	5992	5	ID	ID	NNP
cord-001835-0s7ok4uw	5992	6	:	:	:
cord-001835-0s7ok4uw	5993	1	krishna.bhattiprolu@uni-graz.at	krishna.bhattiprolu@uni-graz.at	NNP
cord-001835-0s7ok4uw	5993	2	Bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5993	3	conjugation	conjugation	NN
cord-001835-0s7ok4uw	5993	4	is	be	VBZ
cord-001835-0s7ok4uw	5993	5	a	a	DT
cord-001835-0s7ok4uw	5993	6	complex	complex	JJ
cord-001835-0s7ok4uw	5993	7	process	process	NN
cord-001835-0s7ok4uw	5993	8	for	for	IN
cord-001835-0s7ok4uw	5993	9	the	the	DT
cord-001835-0s7ok4uw	5993	10	horizontal	horizontal	JJ
cord-001835-0s7ok4uw	5993	11	transfer	transfer	NN
cord-001835-0s7ok4uw	5993	12	of	of	IN
cord-001835-0s7ok4uw	5993	13	single	single	JJ
cord-001835-0s7ok4uw	5993	14	stranded	strand	VBN
cord-001835-0s7ok4uw	5993	15	DNA	dna	NN
cord-001835-0s7ok4uw	5993	16	from	from	IN
cord-001835-0s7ok4uw	5993	17	one	one	CD
cord-001835-0s7ok4uw	5993	18	cell	cell	NN
cord-001835-0s7ok4uw	5993	19	to	to	IN
cord-001835-0s7ok4uw	5993	20	another	another	DT
cord-001835-0s7ok4uw	5993	21	.	.	.
cord-001835-0s7ok4uw	5994	1	This	this	DT
cord-001835-0s7ok4uw	5994	2	mechanism	mechanism	NN
cord-001835-0s7ok4uw	5994	3	also	also	RB
cord-001835-0s7ok4uw	5994	4	leads	lead	VBZ
cord-001835-0s7ok4uw	5994	5	,	,	,
cord-001835-0s7ok4uw	5994	6	for	for	IN
cord-001835-0s7ok4uw	5994	7	example	example	NN
cord-001835-0s7ok4uw	5994	8	,	,	,
cord-001835-0s7ok4uw	5994	9	to	to	IN
cord-001835-0s7ok4uw	5994	10	the	the	DT
cord-001835-0s7ok4uw	5994	11	spread	spread	NN
cord-001835-0s7ok4uw	5994	12	of	of	IN
cord-001835-0s7ok4uw	5994	13	antibiotic	antibiotic	JJ
cord-001835-0s7ok4uw	5994	14	resistance	resistance	NN
cord-001835-0s7ok4uw	5994	15	genes	gene	NNS
cord-001835-0s7ok4uw	5994	16	and	and	CC
cord-001835-0s7ok4uw	5994	17	virulence	virulence	NN
cord-001835-0s7ok4uw	5994	18	factors	factor	NNS
cord-001835-0s7ok4uw	5994	19	among	among	IN
cord-001835-0s7ok4uw	5994	20	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5994	21	species	specie	NNS
cord-001835-0s7ok4uw	5994	22	.	.	.
cord-001835-0s7ok4uw	5995	1	Multi	multi	JJ
cord-001835-0s7ok4uw	5995	2	-	-	JJ
cord-001835-0s7ok4uw	5995	3	protein	protein	JJ
cord-001835-0s7ok4uw	5995	4	complexes	complex	NNS
cord-001835-0s7ok4uw	5995	5	formed	form	VBN
cord-001835-0s7ok4uw	5995	6	at	at	IN
cord-001835-0s7ok4uw	5995	7	the	the	DT
cord-001835-0s7ok4uw	5995	8	origin	origin	NN
cord-001835-0s7ok4uw	5995	9	of	of	IN
cord-001835-0s7ok4uw	5995	10	transfer	transfer	NN
cord-001835-0s7ok4uw	5995	11	(	(	-LRB-
cord-001835-0s7ok4uw	5995	12	oriT	orit	JJ
cord-001835-0s7ok4uw	5995	13	)	)	-RRB-
cord-001835-0s7ok4uw	5995	14	region	region	NN
cord-001835-0s7ok4uw	5995	15	of	of	IN
cord-001835-0s7ok4uw	5995	16	DNA	DNA	NNP
cord-001835-0s7ok4uw	5995	17	and	and	CC
cord-001835-0s7ok4uw	5995	18	at	at	IN
cord-001835-0s7ok4uw	5995	19	the	the	DT
cord-001835-0s7ok4uw	5995	20	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	5995	21	membrane	membrane	NN
cord-001835-0s7ok4uw	5995	22	of	of	IN
cord-001835-0s7ok4uw	5995	23	the	the	DT
cord-001835-0s7ok4uw	5995	24	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5995	25	cell	cell	NN
cord-001835-0s7ok4uw	5995	26	,	,	,
cord-001835-0s7ok4uw	5995	27	initiate	initiate	VB
cord-001835-0s7ok4uw	5995	28	this	this	DT
cord-001835-0s7ok4uw	5995	29	process	process	NN
cord-001835-0s7ok4uw	5995	30	.	.	.
cord-001835-0s7ok4uw	5996	1	Inside	inside	IN
cord-001835-0s7ok4uw	5996	2	the	the	DT
cord-001835-0s7ok4uw	5996	3	membrane	membrane	NN
cord-001835-0s7ok4uw	5996	4	,	,	,
cord-001835-0s7ok4uw	5996	5	the	the	DT
cord-001835-0s7ok4uw	5996	6	relaxosome	relaxosome	NNP
cord-001835-0s7ok4uw	5996	7	identifies	identify	VBZ
cord-001835-0s7ok4uw	5996	8	the	the	DT
cord-001835-0s7ok4uw	5996	9	single	single	JJ
cord-001835-0s7ok4uw	5996	10	strand	strand	NN
cord-001835-0s7ok4uw	5996	11	for	for	IN
cord-001835-0s7ok4uw	5996	12	transfer	transfer	NN
cord-001835-0s7ok4uw	5996	13	in	in	IN
cord-001835-0s7ok4uw	5996	14	a	a	DT
cord-001835-0s7ok4uw	5996	15	plasmid	plasmid	NN
cord-001835-0s7ok4uw	5996	16	DNA	dna	NN
cord-001835-0s7ok4uw	5996	17	,	,	,
cord-001835-0s7ok4uw	5996	18	relaxes	relax	VBZ
cord-001835-0s7ok4uw	5996	19	and	and	CC
cord-001835-0s7ok4uw	5996	20	unwinds	unwind	VBZ
cord-001835-0s7ok4uw	5996	21	it	-PRON-	PRP
cord-001835-0s7ok4uw	5996	22	,	,	,
cord-001835-0s7ok4uw	5996	23	whereas	whereas	IN
cord-001835-0s7ok4uw	5996	24	the	the	DT
cord-001835-0s7ok4uw	5996	25	transferosome	transferosome	NNP
cord-001835-0s7ok4uw	5996	26	is	be	VBZ
cord-001835-0s7ok4uw	5996	27	involved	involve	VBN
cord-001835-0s7ok4uw	5996	28	in	in	IN
cord-001835-0s7ok4uw	5996	29	pilus	pilus	NN
cord-001835-0s7ok4uw	5996	30	formation	formation	NN
cord-001835-0s7ok4uw	5996	31	(	(	-LRB-
cord-001835-0s7ok4uw	5996	32	Type	type	NN
cord-001835-0s7ok4uw	5996	33	IV	IV	NNP
cord-001835-0s7ok4uw	5996	34	secretion	secretion	NN
cord-001835-0s7ok4uw	5996	35	system	system	NN
cord-001835-0s7ok4uw	5996	36	)	)	-RRB-
cord-001835-0s7ok4uw	5996	37	and	and	CC
cord-001835-0s7ok4uw	5996	38	transferring	transfer	VBG
cord-001835-0s7ok4uw	5996	39	the	the	DT
cord-001835-0s7ok4uw	5996	40	gene	gene	NN
cord-001835-0s7ok4uw	5996	41	through	through	IN
cord-001835-0s7ok4uw	5996	42	the	the	DT
cord-001835-0s7ok4uw	5996	43	cytoplasmic	cytoplasmic	JJ
cord-001835-0s7ok4uw	5996	44	membrane	membrane	NN
cord-001835-0s7ok4uw	5996	45	.	.	.
cord-001835-0s7ok4uw	5997	1	These	these	DT
cord-001835-0s7ok4uw	5997	2	events	event	NNS
cord-001835-0s7ok4uw	5997	3	take	take	VBP
cord-001835-0s7ok4uw	5997	4	place	place	NN
cord-001835-0s7ok4uw	5997	5	in	in	IN
cord-001835-0s7ok4uw	5997	6	the	the	DT
cord-001835-0s7ok4uw	5997	7	donor	donor	NN
cord-001835-0s7ok4uw	5997	8	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	5997	9	cell	cell	NN
cord-001835-0s7ok4uw	5997	10	along	along	IN
cord-001835-0s7ok4uw	5997	11	with	with	IN
cord-001835-0s7ok4uw	5997	12	several	several	JJ
cord-001835-0s7ok4uw	5997	13	other	other	JJ
cord-001835-0s7ok4uw	5997	14	auxiliary	auxiliary	JJ
cord-001835-0s7ok4uw	5997	15	proteins	protein	NNS
cord-001835-0s7ok4uw	5997	16	[	[	-LRB-
cord-001835-0s7ok4uw	5997	17	1	1	CD
cord-001835-0s7ok4uw	5997	18	]	]	-RRB-
cord-001835-0s7ok4uw	5998	1	The	the	DT
cord-001835-0s7ok4uw	5998	2	bifunctional	bifunctional	JJ
cord-001835-0s7ok4uw	5998	3	enzyme	enzyme	NN
cord-001835-0s7ok4uw	5998	4	TraI	TraI	NNP
cord-001835-0s7ok4uw	5998	5	of	of	IN
cord-001835-0s7ok4uw	5998	6	plasmid	plasmid	NNP
cord-001835-0s7ok4uw	5998	7	R1	R1	NNP
cord-001835-0s7ok4uw	5998	8	plays	play	VBZ
cord-001835-0s7ok4uw	5998	9	a	a	DT
cord-001835-0s7ok4uw	5998	10	crucial	crucial	JJ
cord-001835-0s7ok4uw	5998	11	role	role	NN
cord-001835-0s7ok4uw	5998	12	in	in	IN
cord-001835-0s7ok4uw	5998	13	the	the	DT
cord-001835-0s7ok4uw	5998	14	relaxosome	relaxosome	NN
cord-001835-0s7ok4uw	5998	15	activity	activity	NN
cord-001835-0s7ok4uw	5998	16	,	,	,
cord-001835-0s7ok4uw	5998	17	as	as	IN
cord-001835-0s7ok4uw	5998	18	it	-PRON-	PRP
cord-001835-0s7ok4uw	5998	19	contains	contain	VBZ
cord-001835-0s7ok4uw	5998	20	both	both	CC
cord-001835-0s7ok4uw	5998	21	a	a	DT
cord-001835-0s7ok4uw	5998	22	relaxase	relaxase	NN
cord-001835-0s7ok4uw	5998	23	and	and	CC
cord-001835-0s7ok4uw	5998	24	helicase	helicase	NN
cord-001835-0s7ok4uw	5998	25	domain	domain	NN
cord-001835-0s7ok4uw	5998	26	.	.	.
cord-001835-0s7ok4uw	5999	1	To	to	TO
cord-001835-0s7ok4uw	5999	2	exert	exert	VB
cord-001835-0s7ok4uw	5999	3	its	-PRON-	PRP$
cord-001835-0s7ok4uw	5999	4	functions	function	NNS
cord-001835-0s7ok4uw	5999	5	on	on	IN
cord-001835-0s7ok4uw	5999	6	DNA	DNA	NNP
cord-001835-0s7ok4uw	5999	7	,	,	,
cord-001835-0s7ok4uw	5999	8	TraI	TraI	NNP
cord-001835-0s7ok4uw	5999	9	works	work	VBZ
cord-001835-0s7ok4uw	5999	10	in	in	IN
cord-001835-0s7ok4uw	5999	11	close	close	JJ
cord-001835-0s7ok4uw	5999	12	co	co	JJ
cord-001835-0s7ok4uw	5999	13	-	-	NN
cord-001835-0s7ok4uw	5999	14	ordination	ordination	NN
cord-001835-0s7ok4uw	5999	15	with	with	IN
cord-001835-0s7ok4uw	5999	16	other	other	JJ
cord-001835-0s7ok4uw	5999	17	relaxosome	relaxosome	NNP
cord-001835-0s7ok4uw	5999	18	proteins	protein	NNS
cord-001835-0s7ok4uw	5999	19	like	like	IN
cord-001835-0s7ok4uw	5999	20	TraY	TraY	NNP
cord-001835-0s7ok4uw	5999	21	,	,	,
cord-001835-0s7ok4uw	5999	22	TraM	TraM	NNP
cord-001835-0s7ok4uw	5999	23	and	and	CC
cord-001835-0s7ok4uw	5999	24	the	the	DT
cord-001835-0s7ok4uw	5999	25	integration	integration	NN
cord-001835-0s7ok4uw	5999	26	host	host	NN
cord-001835-0s7ok4uw	5999	27	factor	factor	NN
cord-001835-0s7ok4uw	5999	28	.	.	.
cord-001835-0s7ok4uw	6000	1	TraI	TraI	NNP
cord-001835-0s7ok4uw	6000	2	is	be	VBZ
cord-001835-0s7ok4uw	6000	3	a	a	DT
cord-001835-0s7ok4uw	6000	4	1756	1756	CD
cord-001835-0s7ok4uw	6000	5	residual	residual	JJ
cord-001835-0s7ok4uw	6000	6	protein	protein	NN
cord-001835-0s7ok4uw	6000	7	and	and	CC
cord-001835-0s7ok4uw	6000	8	contains	contain	VBZ
cord-001835-0s7ok4uw	6000	9	3	3	CD
cord-001835-0s7ok4uw	6000	10	major	major	JJ
cord-001835-0s7ok4uw	6000	11	domains	domain	NNS
cord-001835-0s7ok4uw	6000	12	:	:	:
cord-001835-0s7ok4uw	6000	13	N	n	CD
cord-001835-0s7ok4uw	6000	14	-	-	HYPH
cord-001835-0s7ok4uw	6000	15	terminal	terminal	JJ
cord-001835-0s7ok4uw	6000	16	relaxase	relaxase	NN
cord-001835-0s7ok4uw	6000	17	domain	domain	NN
cord-001835-0s7ok4uw	6000	18	,	,	,
cord-001835-0s7ok4uw	6000	19	a	a	DT
cord-001835-0s7ok4uw	6000	20	central	central	JJ
cord-001835-0s7ok4uw	6000	21	helicase	helicase	NN
cord-001835-0s7ok4uw	6000	22	domain	domain	NN
cord-001835-0s7ok4uw	6000	23	and	and	CC
cord-001835-0s7ok4uw	6000	24	a	a	DT
cord-001835-0s7ok4uw	6000	25	C	c	NN
cord-001835-0s7ok4uw	6000	26	terminal	terminal	NN
cord-001835-0s7ok4uw	6000	27	domain	domain	NN
cord-001835-0s7ok4uw	6000	28	(	(	-LRB-
cord-001835-0s7ok4uw	6000	29	CTD	CTD	NNP
cord-001835-0s7ok4uw	6000	30	)	)	-RRB-
cord-001835-0s7ok4uw	6000	31	.	.	.
cord-001835-0s7ok4uw	6001	1	The	the	DT
cord-001835-0s7ok4uw	6001	2	structure	structure	NN
cord-001835-0s7ok4uw	6001	3	of	of	IN
cord-001835-0s7ok4uw	6001	4	the	the	DT
cord-001835-0s7ok4uw	6001	5	C	C	NNP
cord-001835-0s7ok4uw	6001	6	-	-	HYPH
cord-001835-0s7ok4uw	6001	7	terminal	terminal	NN
cord-001835-0s7ok4uw	6001	8	domain	domain	NN
cord-001835-0s7ok4uw	6001	9	until	until	IN
cord-001835-0s7ok4uw	6001	10	residue	residue	NN
cord-001835-0s7ok4uw	6001	11	1629	1629	CD
cord-001835-0s7ok4uw	6001	12	has	have	VBZ
cord-001835-0s7ok4uw	6001	13	been	be	VBN
cord-001835-0s7ok4uw	6001	14	solved	solve	VBN
cord-001835-0s7ok4uw	6001	15	by	by	IN
cord-001835-0s7ok4uw	6001	16	crystallography	crystallography	NN
cord-001835-0s7ok4uw	6001	17	,	,	,
cord-001835-0s7ok4uw	6001	18	while	while	IN
cord-001835-0s7ok4uw	6001	19	the	the	DT
cord-001835-0s7ok4uw	6001	20	structure	structure	NN
cord-001835-0s7ok4uw	6001	21	and	and	CC
cord-001835-0s7ok4uw	6001	22	function	function	NN
cord-001835-0s7ok4uw	6001	23	of	of	IN
cord-001835-0s7ok4uw	6001	24	the	the	DT
cord-001835-0s7ok4uw	6001	25	remaining	remain	VBG
cord-001835-0s7ok4uw	6001	26	130	130	CD
cord-001835-0s7ok4uw	6001	27	residues	residue	NNS
cord-001835-0s7ok4uw	6001	28	remained	remain	VBD
cord-001835-0s7ok4uw	6001	29	undetermined	undetermined	JJ
cord-001835-0s7ok4uw	6001	30	[	[	-LRB-
cord-001835-0s7ok4uw	6001	31	2	2	CD
cord-001835-0s7ok4uw	6001	32	]	]	-RRB-
cord-001835-0s7ok4uw	6001	33	.	.	.
cord-001835-0s7ok4uw	6002	1	There	there	EX
cord-001835-0s7ok4uw	6002	2	are	be	VBP
cord-001835-0s7ok4uw	6002	3	SAXS	SAXS	NNP
cord-001835-0s7ok4uw	6002	4	models	model	NNS
cord-001835-0s7ok4uw	6002	5	and	and	CC
cord-001835-0s7ok4uw	6002	6	crystallographic	crystallographic	JJ
cord-001835-0s7ok4uw	6002	7	structures	structure	NNS
cord-001835-0s7ok4uw	6002	8	for	for	IN
cord-001835-0s7ok4uw	6002	9	different	different	JJ
cord-001835-0s7ok4uw	6002	10	parts	part	NNS
cord-001835-0s7ok4uw	6002	11	of	of	IN
cord-001835-0s7ok4uw	6002	12	TraI	TraI	NNP
cord-001835-0s7ok4uw	6002	13	and	and	CC
cord-001835-0s7ok4uw	6002	14	also	also	RB
cord-001835-0s7ok4uw	6002	15	for	for	IN
cord-001835-0s7ok4uw	6002	16	the	the	DT
cord-001835-0s7ok4uw	6002	17	full	full	JJ
cord-001835-0s7ok4uw	6002	18	length	length	NN
cord-001835-0s7ok4uw	6002	19	protein	protein	NN
cord-001835-0s7ok4uw	6002	20	.	.	.
cord-001835-0s7ok4uw	6002	21	 	 	_SP
cord-001835-0s7ok4uw	6003	1	Prediction	prediction	NN
cord-001835-0s7ok4uw	6003	2	of	of	IN
cord-001835-0s7ok4uw	6003	3	cleavage	cleavage	NN
cord-001835-0s7ok4uw	6003	4	specificity	specificity	NN
cord-001835-0s7ok4uw	6003	5	in	in	IN
cord-001835-0s7ok4uw	6003	6	HCV	HCV	NNP
cord-001835-0s7ok4uw	6003	7	NS3/4A	ns3/4a	NN
cord-001835-0s7ok4uw	6003	8	serine	serine	NN
cord-001835-0s7ok4uw	6003	9	protease	protease	NN
cord-001835-0s7ok4uw	6003	10	and	and	CC
cord-001835-0s7ok4uw	6003	11	AdV2	adv2	JJ
cord-001835-0s7ok4uw	6003	12	cysteine	cysteine	NN
cord-001835-0s7ok4uw	6003	13	protease	protease	NN
cord-001835-0s7ok4uw	6003	14	systems	system	NNS
cord-001835-0s7ok4uw	6003	15	by	by	IN
cord-001835-0s7ok4uw	6003	16	biased	biased	JJ
cord-001835-0s7ok4uw	6003	17	sequence	sequence	NN
cord-001835-0s7ok4uw	6003	18	search	search	NN
cord-001835-0s7ok4uw	6003	19	threading	threading	NN
cord-001835-0s7ok4uw	6003	20	Gonca	Gonca	NNP
cord-001835-0s7ok4uw	6003	21	Ozdemir	Ozdemir	NNP
cord-001835-0s7ok4uw	6003	22	Isik	Isik	NNP
cord-001835-0s7ok4uw	6003	23	1	1	CD
cord-001835-0s7ok4uw	6003	24	,	,	,
cord-001835-0s7ok4uw	6003	25	A.Nevra	A.Nevra	NNP
cord-001835-0s7ok4uw	6003	26	Ozer	Ozer	NNP
cord-001835-0s7ok4uw	6003	27	1	1	CD
cord-001835-0s7ok4uw	6003	28	1	1	CD
cord-001835-0s7ok4uw	6003	29	Department	Department	NNP
cord-001835-0s7ok4uw	6003	30	of	of	IN
cord-001835-0s7ok4uw	6003	31	Bioengineering	Bioengineering	NNP
cord-001835-0s7ok4uw	6003	32	,	,	,
cord-001835-0s7ok4uw	6003	33	Faculty	Faculty	NNP
cord-001835-0s7ok4uw	6003	34	of	of	IN
cord-001835-0s7ok4uw	6003	35	Engineering	Engineering	NNP
cord-001835-0s7ok4uw	6003	36	,	,	,
cord-001835-0s7ok4uw	6003	37	Marmara	Marmara	NNP
cord-001835-0s7ok4uw	6003	38	University	University	NNP
cord-001835-0s7ok4uw	6003	39	Proteases	Proteases	NNP
cord-001835-0s7ok4uw	6003	40	are	be	VBP
cord-001835-0s7ok4uw	6003	41	enzymes	enzyme	NNS
cord-001835-0s7ok4uw	6003	42	which	which	WDT
cord-001835-0s7ok4uw	6003	43	recognize	recognize	VBP
cord-001835-0s7ok4uw	6003	44	specific	specific	JJ
cord-001835-0s7ok4uw	6003	45	substrate	substrate	NN
cord-001835-0s7ok4uw	6003	46	sequences	sequence	NNS
cord-001835-0s7ok4uw	6003	47	and	and	CC
cord-001835-0s7ok4uw	6003	48	catalyze	catalyze	VB
cord-001835-0s7ok4uw	6003	49	the	the	DT
cord-001835-0s7ok4uw	6003	50	hydrolysis	hydrolysis	NN
cord-001835-0s7ok4uw	6003	51	of	of	IN
cord-001835-0s7ok4uw	6003	52	designated	designate	VBN
cord-001835-0s7ok4uw	6003	53	peptide	peptide	JJ
cord-001835-0s7ok4uw	6003	54	bonds	bond	NNS
cord-001835-0s7ok4uw	6003	55	to	to	TO
cord-001835-0s7ok4uw	6003	56	activate	activate	VB
cord-001835-0s7ok4uw	6003	57	or	or	CC
cord-001835-0s7ok4uw	6003	58	degrade	degrade	VB
cord-001835-0s7ok4uw	6003	59	them	-PRON-	PRP
cord-001835-0s7ok4uw	6003	60	.	.	.
cord-001835-0s7ok4uw	6004	1	Due	due	IN
cord-001835-0s7ok4uw	6004	2	to	to	IN
cord-001835-0s7ok4uw	6004	3	the	the	DT
cord-001835-0s7ok4uw	6004	4	biological	biological	JJ
cord-001835-0s7ok4uw	6004	5	importance	importance	NN
cord-001835-0s7ok4uw	6004	6	of	of	IN
cord-001835-0s7ok4uw	6004	7	proteases	protease	NNS
cord-001835-0s7ok4uw	6004	8	,	,	,
cord-001835-0s7ok4uw	6004	9	it	-PRON-	PRP
cord-001835-0s7ok4uw	6004	10	is	be	VBZ
cord-001835-0s7ok4uw	6004	11	particularly	particularly	RB
cord-001835-0s7ok4uw	6004	12	important	important	JJ
cord-001835-0s7ok4uw	6004	13	to	to	TO
cord-001835-0s7ok4uw	6004	14	identify	identify	VB
cord-001835-0s7ok4uw	6004	15	the	the	DT
cord-001835-0s7ok4uw	6004	16	recognition	recognition	NN
cord-001835-0s7ok4uw	6004	17	and	and	CC
cord-001835-0s7ok4uw	6004	18	binding	binding	NN
cord-001835-0s7ok4uw	6004	19	mechanisms	mechanism	NNS
cord-001835-0s7ok4uw	6004	20	of	of	IN
cord-001835-0s7ok4uw	6004	21	protease	protease	NN
cord-001835-0s7ok4uw	6004	22	-	-	HYPH
cord-001835-0s7ok4uw	6004	23	substrate	substrate	NN
cord-001835-0s7ok4uw	6004	24	complex	complex	JJ
cord-001835-0s7ok4uw	6004	25	structures	structure	NNS
cord-001835-0s7ok4uw	6004	26	in	in	IN
cord-001835-0s7ok4uw	6004	27	drug	drug	NN
cord-001835-0s7ok4uw	6004	28	development	development	NN
cord-001835-0s7ok4uw	6004	29	studies	study	NNS
cord-001835-0s7ok4uw	6004	30	.	.	.
cord-001835-0s7ok4uw	6005	1	The	the	DT
cord-001835-0s7ok4uw	6005	2	assessment	assessment	NN
cord-001835-0s7ok4uw	6005	3	of	of	IN
cord-001835-0s7ok4uw	6005	4	substrate	substrate	JJ
cord-001835-0s7ok4uw	6005	5	specificity	specificity	NN
cord-001835-0s7ok4uw	6005	6	in	in	IN
cord-001835-0s7ok4uw	6005	7	protease	protease	NN
cord-001835-0s7ok4uw	6005	8	systems	system	NNS
cord-001835-0s7ok4uw	6005	9	is	be	VBZ
cord-001835-0s7ok4uw	6005	10	crucial	crucial	JJ
cord-001835-0s7ok4uw	6005	11	,	,	,
cord-001835-0s7ok4uw	6005	12	where	where	WRB
cord-001835-0s7ok4uw	6005	13	interpreting	interpret	VBG
cord-001835-0s7ok4uw	6005	14	the	the	DT
cord-001835-0s7ok4uw	6005	15	adaptability	adaptability	NN
cord-001835-0s7ok4uw	6005	16	of	of	IN
cord-001835-0s7ok4uw	6005	17	substrate	substrate	JJ
cord-001835-0s7ok4uw	6005	18	residue	residue	NN
cord-001835-0s7ok4uw	6005	19	positions	position	NNS
cord-001835-0s7ok4uw	6005	20	can	can	MD
cord-001835-0s7ok4uw	6005	21	be	be	VB
cord-001835-0s7ok4uw	6005	22	useful	useful	JJ
cord-001835-0s7ok4uw	6005	23	in	in	IN
cord-001835-0s7ok4uw	6005	24	understanding	understanding	NN
cord-001835-0s7ok4uw	6005	25	how	how	WRB
cord-001835-0s7ok4uw	6005	26	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	6005	27	might	may	MD
cord-001835-0s7ok4uw	6005	28	best	best	RB
cord-001835-0s7ok4uw	6005	29	fit	fit	VB
cord-001835-0s7ok4uw	6005	30	within	within	IN
cord-001835-0s7ok4uw	6005	31	the	the	DT
cord-001835-0s7ok4uw	6005	32	substrate	substrate	NN
cord-001835-0s7ok4uw	6005	33	binding	bind	VBG
cord-001835-0s7ok4uw	6005	34	sites	site	NNS
cord-001835-0s7ok4uw	6005	35	and	and	CC
cord-001835-0s7ok4uw	6005	36	aid	aid	NN
cord-001835-0s7ok4uw	6005	37	in	in	IN
cord-001835-0s7ok4uw	6005	38	the	the	DT
cord-001835-0s7ok4uw	6005	39	design	design	NN
cord-001835-0s7ok4uw	6005	40	of	of	IN
cord-001835-0s7ok4uw	6005	41	potent	potent	JJ
cord-001835-0s7ok4uw	6005	42	selective	selective	JJ
cord-001835-0s7ok4uw	6005	43	inhibitors	inhibitor	NNS
cord-001835-0s7ok4uw	6005	44	.	.	.
cord-001835-0s7ok4uw	6006	1	Substrate	substrate	NN
cord-001835-0s7ok4uw	6006	2	specificity	specificity	NN
cord-001835-0s7ok4uw	6006	3	is	be	VBZ
cord-001835-0s7ok4uw	6006	4	generally	generally	RB
cord-001835-0s7ok4uw	6006	5	determined	determine	VBN
cord-001835-0s7ok4uw	6006	6	by	by	IN
cord-001835-0s7ok4uw	6006	7	the	the	DT
cord-001835-0s7ok4uw	6006	8	amino	amino	NN
cord-001835-0s7ok4uw	6006	9	acid	acid	NN
cord-001835-0s7ok4uw	6006	10	profile	profile	NN
cord-001835-0s7ok4uw	6006	11	,	,	,
cord-001835-0s7ok4uw	6006	12	structural	structural	JJ
cord-001835-0s7ok4uw	6006	13	features	feature	NNS
cord-001835-0s7ok4uw	6006	14	and	and	CC
cord-001835-0s7ok4uw	6006	15	distinct	distinct	JJ
cord-001835-0s7ok4uw	6006	16	molecular	molecular	JJ
cord-001835-0s7ok4uw	6006	17	interactions	interaction	NNS
cord-001835-0s7ok4uw	6006	18	.	.	.
cord-001835-0s7ok4uw	6007	1	Besides	besides	IN
cord-001835-0s7ok4uw	6007	2	experimental	experimental	JJ
cord-001835-0s7ok4uw	6007	3	methods	method	NNS
cord-001835-0s7ok4uw	6007	4	,	,	,
cord-001835-0s7ok4uw	6007	5	computational	computational	JJ
cord-001835-0s7ok4uw	6007	6	tools	tool	NNS
cord-001835-0s7ok4uw	6007	7	for	for	IN
cord-001835-0s7ok4uw	6007	8	prediction	prediction	NN
cord-001835-0s7ok4uw	6007	9	of	of	IN
cord-001835-0s7ok4uw	6007	10	natural	natural	JJ
cord-001835-0s7ok4uw	6007	11	substrate	substrate	NN
cord-001835-0s7ok4uw	6007	12	cleavage	cleavage	NN
cord-001835-0s7ok4uw	6007	13	sites	site	NNS
cord-001835-0s7ok4uw	6007	14	,	,	,
cord-001835-0s7ok4uw	6007	15	such	such	JJ
cord-001835-0s7ok4uw	6007	16	as	as	IN
cord-001835-0s7ok4uw	6007	17	threading	threading	NN
cord-001835-0s7ok4uw	6007	18	,	,	,
cord-001835-0s7ok4uw	6007	19	have	have	VBP
cord-001835-0s7ok4uw	6007	20	emerged	emerge	VBN
cord-001835-0s7ok4uw	6007	21	as	as	IN
cord-001835-0s7ok4uw	6007	22	useful	useful	JJ
cord-001835-0s7ok4uw	6007	23	alternative	alternative	JJ
cord-001835-0s7ok4uw	6007	24	approaches	approach	NNS
cord-001835-0s7ok4uw	6007	25	to	to	TO
cord-001835-0s7ok4uw	6007	26	provide	provide	VB
cord-001835-0s7ok4uw	6007	27	valuable	valuable	JJ
cord-001835-0s7ok4uw	6007	28	insights	insight	NNS
cord-001835-0s7ok4uw	6007	29	into	into	IN
cord-001835-0s7ok4uw	6007	30	complex	complex	JJ
cord-001835-0s7ok4uw	6007	31	enzyme	enzyme	NN
cord-001835-0s7ok4uw	6007	32	-	-	HYPH
cord-001835-0s7ok4uw	6007	33	substrate	substrate	NN
cord-001835-0s7ok4uw	6007	34	interactions	interaction	NNS
cord-001835-0s7ok4uw	6007	35	.	.	.
cord-001835-0s7ok4uw	6008	1	In	in	IN
cord-001835-0s7ok4uw	6008	2	this	this	DT
cord-001835-0s7ok4uw	6008	3	work	work	NN
cord-001835-0s7ok4uw	6008	4	,	,	,
cord-001835-0s7ok4uw	6008	5	the	the	DT
cord-001835-0s7ok4uw	6008	6	substrate	substrate	NN
cord-001835-0s7ok4uw	6008	7	variability	variability	NN
cord-001835-0s7ok4uw	6008	8	and	and	CC
cord-001835-0s7ok4uw	6008	9	substrate	substrate	NN
cord-001835-0s7ok4uw	6008	10	specificity	specificity	NN
cord-001835-0s7ok4uw	6008	11	of	of	IN
cord-001835-0s7ok4uw	6008	12	the	the	DT
cord-001835-0s7ok4uw	6008	13	Hepatitis	Hepatitis	NNP
cord-001835-0s7ok4uw	6008	14	C	C	NNP
cord-001835-0s7ok4uw	6008	15	virus	virus	NN
cord-001835-0s7ok4uw	6008	16	(	(	-LRB-
cord-001835-0s7ok4uw	6008	17	HCV	HCV	NNP
cord-001835-0s7ok4uw	6008	18	)	)	-RRB-
cord-001835-0s7ok4uw	6008	19	NS3/4A	ns3/4a	JJ
cord-001835-0s7ok4uw	6008	20	serine	serine	NN
cord-001835-0s7ok4uw	6008	21	protease	protease	NN
cord-001835-0s7ok4uw	6008	22	and	and	CC
cord-001835-0s7ok4uw	6008	23	the	the	DT
cord-001835-0s7ok4uw	6008	24	Adenovirus	Adenovirus	NNP
cord-001835-0s7ok4uw	6008	25	2	2	CD
cord-001835-0s7ok4uw	6008	26	(	(	-LRB-
cord-001835-0s7ok4uw	6008	27	AdV2	AdV2	NNP
cord-001835-0s7ok4uw	6008	28	)	)	-RRB-
cord-001835-0s7ok4uw	6008	29	cysteine	cysteine	NN
cord-001835-0s7ok4uw	6008	30	protease	protease	NN
cord-001835-0s7ok4uw	6008	31	was	be	VBD
cord-001835-0s7ok4uw	6008	32	investigated	investigate	VBN
cord-001835-0s7ok4uw	6008	33	by	by	IN
cord-001835-0s7ok4uw	6008	34	the	the	DT
cord-001835-0s7ok4uw	6008	35	biased	biased	JJ
cord-001835-0s7ok4uw	6008	36	sequence	sequence	NN
cord-001835-0s7ok4uw	6008	37	search	search	NN
cord-001835-0s7ok4uw	6008	38	threading	threading	NN
cord-001835-0s7ok4uw	6008	39	(	(	-LRB-
cord-001835-0s7ok4uw	6008	40	BSST	BSST	NNP
cord-001835-0s7ok4uw	6008	41	)	)	-RRB-
cord-001835-0s7ok4uw	6008	42	methodology	methodology	NN
cord-001835-0s7ok4uw	6008	43	.	.	.
cord-001835-0s7ok4uw	6009	1	Using	use	VBG
cord-001835-0s7ok4uw	6009	2	available	available	JJ
cord-001835-0s7ok4uw	6009	3	crystal	crystal	NN
cord-001835-0s7ok4uw	6009	4	structures	structure	NNS
cord-001835-0s7ok4uw	6009	5	of	of	IN
cord-001835-0s7ok4uw	6009	6	the	the	DT
cord-001835-0s7ok4uw	6009	7	proteases	protease	NNS
cord-001835-0s7ok4uw	6009	8	,	,	,
cord-001835-0s7ok4uw	6009	9	the	the	DT
cord-001835-0s7ok4uw	6009	10	template	template	NN
cord-001835-0s7ok4uw	6009	11	structures	structure	NNS
cord-001835-0s7ok4uw	6009	12	for	for	IN
cord-001835-0s7ok4uw	6009	13	the	the	DT
cord-001835-0s7ok4uw	6009	14	substrate	substrate	NN
cord-001835-0s7ok4uw	6009	15	-	-	HYPH
cord-001835-0s7ok4uw	6009	16	bound	bind	VBN
cord-001835-0s7ok4uw	6009	17	proteases	protease	NNS
cord-001835-0s7ok4uw	6009	18	were	be	VBD
cord-001835-0s7ok4uw	6009	19	created	create	VBN
cord-001835-0s7ok4uw	6009	20	in	in	IN
cord-001835-0s7ok4uw	6009	21	silico	silico	NNS
cord-001835-0s7ok4uw	6009	22	by	by	IN
cord-001835-0s7ok4uw	6009	23	performing	perform	VBG
cord-001835-0s7ok4uw	6009	24	various	various	JJ
cord-001835-0s7ok4uw	6009	25	peptide	peptide	NN
cord-001835-0s7ok4uw	6009	26	building	building	NN
cord-001835-0s7ok4uw	6009	27	and	and	CC
cord-001835-0s7ok4uw	6009	28	docking	docking	NN
cord-001835-0s7ok4uw	6009	29	procedures	procedure	NNS
cord-001835-0s7ok4uw	6009	30	followed	follow	VBN
cord-001835-0s7ok4uw	6009	31	by	by	IN
cord-001835-0s7ok4uw	6009	32	energy	energy	NN
cord-001835-0s7ok4uw	6009	33	minimization	minimization	NN
cord-001835-0s7ok4uw	6009	34	and	and	CC
cord-001835-0s7ok4uw	6009	35	molecular	molecular	JJ
cord-001835-0s7ok4uw	6009	36	dynamics	dynamic	NNS
cord-001835-0s7ok4uw	6009	37	(	(	-LRB-
cord-001835-0s7ok4uw	6009	38	MD	MD	NNP
cord-001835-0s7ok4uw	6009	39	)	)	-RRB-
cord-001835-0s7ok4uw	6009	40	simulations	simulation	NNS
cord-001835-0s7ok4uw	6009	41	.	.	.
cord-001835-0s7ok4uw	6010	1	BSST	BSST	NNP
cord-001835-0s7ok4uw	6010	2	was	be	VBD
cord-001835-0s7ok4uw	6010	3	performed	perform	VBN
cord-001835-0s7ok4uw	6010	4	starting	start	VBG
cord-001835-0s7ok4uw	6010	5	with	with	IN
cord-001835-0s7ok4uw	6010	6	known	know	VBN
cord-001835-0s7ok4uw	6010	7	binding	bind	VBG
cord-001835-0s7ok4uw	6010	8	,	,	,
cord-001835-0s7ok4uw	6010	9	nonbinding	nonbinding	JJ
cord-001835-0s7ok4uw	6010	10	and	and	CC
cord-001835-0s7ok4uw	6010	11	some	some	DT
cord-001835-0s7ok4uw	6010	12	random	random	JJ
cord-001835-0s7ok4uw	6010	13	peptide	peptide	NN
cord-001835-0s7ok4uw	6010	14	sequences	sequence	NNS
cord-001835-0s7ok4uw	6010	15	that	that	WDT
cord-001835-0s7ok4uw	6010	16	were	be	VBD
cord-001835-0s7ok4uw	6010	17	threaded	thread	VBN
cord-001835-0s7ok4uw	6010	18	onto	onto	IN
cord-001835-0s7ok4uw	6010	19	the	the	DT
cord-001835-0s7ok4uw	6010	20	template	template	NN
cord-001835-0s7ok4uw	6010	21	complex	complex	JJ
cord-001835-0s7ok4uw	6010	22	structures	structure	NNS
cord-001835-0s7ok4uw	6010	23	,	,	,
cord-001835-0s7ok4uw	6010	24	and	and	CC
cord-001835-0s7ok4uw	6010	25	low	low	JJ
cord-001835-0s7ok4uw	6010	26	energy	energy	NN
cord-001835-0s7ok4uw	6010	27	sequences	sequence	NNS
cord-001835-0s7ok4uw	6010	28	were	be	VBD
cord-001835-0s7ok4uw	6010	29	searched	search	VBN
cord-001835-0s7ok4uw	6010	30	using	use	VBG
cord-001835-0s7ok4uw	6010	31	lowresolution	lowresolution	NN
cord-001835-0s7ok4uw	6010	32	knowledge	knowledge	NN
cord-001835-0s7ok4uw	6010	33	-	-	HYPH
cord-001835-0s7ok4uw	6010	34	based	base	VBN
cord-001835-0s7ok4uw	6010	35	potentials	potential	NNS
cord-001835-0s7ok4uw	6010	36	.	.	.
cord-001835-0s7ok4uw	6011	1	Then	then	RB
cord-001835-0s7ok4uw	6011	2	,	,	,
cord-001835-0s7ok4uw	6011	3	target	target	NN
cord-001835-0s7ok4uw	6011	4	sequences	sequence	NNS
cord-001835-0s7ok4uw	6011	5	of	of	IN
cord-001835-0s7ok4uw	6011	6	yet	yet	RB
cord-001835-0s7ok4uw	6011	7	unidentified	unidentified	JJ
cord-001835-0s7ok4uw	6011	8	potential	potential	JJ
cord-001835-0s7ok4uw	6011	9	substrates	substrate	NNS
cord-001835-0s7ok4uw	6011	10	were	be	VBD
cord-001835-0s7ok4uw	6011	11	predicted	predict	VBN
cord-001835-0s7ok4uw	6011	12	by	by	IN
cord-001835-0s7ok4uw	6011	13	statistical	statistical	JJ
cord-001835-0s7ok4uw	6011	14	probability	probability	NN
cord-001835-0s7ok4uw	6011	15	approaches	approach	NNS
cord-001835-0s7ok4uw	6011	16	applied	apply	VBN
cord-001835-0s7ok4uw	6011	17	on	on	IN
cord-001835-0s7ok4uw	6011	18	the	the	DT
cord-001835-0s7ok4uw	6011	19	low	low	JJ
cord-001835-0s7ok4uw	6011	20	energy	energy	NN
cord-001835-0s7ok4uw	6011	21	sequences	sequence	NNS
cord-001835-0s7ok4uw	6011	22	generated	generate	VBD
cord-001835-0s7ok4uw	6011	23	.	.	.
cord-001835-0s7ok4uw	6012	1	The	the	DT
cord-001835-0s7ok4uw	6012	2	results	result	NNS
cord-001835-0s7ok4uw	6012	3	show	show	VBP
cord-001835-0s7ok4uw	6012	4	that	that	IN
cord-001835-0s7ok4uw	6012	5	the	the	DT
cord-001835-0s7ok4uw	6012	6	majority	majority	NN
cord-001835-0s7ok4uw	6012	7	of	of	IN
cord-001835-0s7ok4uw	6012	8	the	the	DT
cord-001835-0s7ok4uw	6012	9	predicted	predict	VBN
cord-001835-0s7ok4uw	6012	10	substrate	substrate	NN
cord-001835-0s7ok4uw	6012	11	positions	position	NNS
cord-001835-0s7ok4uw	6012	12	correspond	correspond	VBP
cord-001835-0s7ok4uw	6012	13	to	to	IN
cord-001835-0s7ok4uw	6012	14	the	the	DT
cord-001835-0s7ok4uw	6012	15	natural	natural	JJ
cord-001835-0s7ok4uw	6012	16	substrate	substrate	NN
cord-001835-0s7ok4uw	6012	17	sequences	sequence	NNS
cord-001835-0s7ok4uw	6012	18	with	with	IN
cord-001835-0s7ok4uw	6012	19	conserved	conserved	JJ
cord-001835-0s7ok4uw	6012	20	amino	amino	NN
cord-001835-0s7ok4uw	6012	21	acid	acid	NN
cord-001835-0s7ok4uw	6012	22	preferences	preference	NNS
cord-001835-0s7ok4uw	6012	23	,	,	,
cord-001835-0s7ok4uw	6012	24	while	while	IN
cord-001835-0s7ok4uw	6012	25	some	some	DT
cord-001835-0s7ok4uw	6012	26	positions	position	NNS
cord-001835-0s7ok4uw	6012	27	exhibit	exhibit	VBP
cord-001835-0s7ok4uw	6012	28	variability	variability	NN
cord-001835-0s7ok4uw	6012	29	.	.	.
cord-001835-0s7ok4uw	6013	1	For	for	IN
cord-001835-0s7ok4uw	6013	2	NS3/4A	ns3/4a	JJ
cord-001835-0s7ok4uw	6013	3	serine	serine	NN
cord-001835-0s7ok4uw	6013	4	protease	protease	NN
cord-001835-0s7ok4uw	6013	5	cleavage	cleavage	NN
cord-001835-0s7ok4uw	6013	6	,	,	,
cord-001835-0s7ok4uw	6013	7	the	the	DT
cord-001835-0s7ok4uw	6013	8	significant	significant	JJ
cord-001835-0s7ok4uw	6013	9	selection	selection	NN
cord-001835-0s7ok4uw	6013	10	for	for	IN
cord-001835-0s7ok4uw	6013	11	Pro	Pro	NNP
cord-001835-0s7ok4uw	6013	12	at	at	IN
cord-001835-0s7ok4uw	6013	13	P2	P2	NNP
cord-001835-0s7ok4uw	6013	14	and	and	CC
cord-001835-0s7ok4uw	6013	15	Cys	Cys	NNP
cord-001835-0s7ok4uw	6013	16	at	at	IN
cord-001835-0s7ok4uw	6013	17	P1	P1	NNP
cord-001835-0s7ok4uw	6013	18	positions	position	NNS
cord-001835-0s7ok4uw	6013	19	is	be	VBZ
cord-001835-0s7ok4uw	6013	20	Zearalenone	Zearalenone	NNP
cord-001835-0s7ok4uw	6013	21	is	be	VBZ
cord-001835-0s7ok4uw	6013	22	a	a	DT
cord-001835-0s7ok4uw	6013	23	mycotoxin	mycotoxin	NN
cord-001835-0s7ok4uw	6013	24	produced	produce	VBN
cord-001835-0s7ok4uw	6013	25	by	by	IN
cord-001835-0s7ok4uw	6013	26	Fusarium	Fusarium	NNP
cord-001835-0s7ok4uw	6013	27	graminearum	graminearum	NNP
cord-001835-0s7ok4uw	6013	28	and	and	CC
cord-001835-0s7ok4uw	6013	29	related	related	JJ
cord-001835-0s7ok4uw	6013	30	Fusarium	fusarium	NN
cord-001835-0s7ok4uw	6013	31	species	specie	NNS
cord-001835-0s7ok4uw	6013	32	.	.	.
cord-001835-0s7ok4uw	6014	1	F.	F.	NNP
cord-001835-0s7ok4uw	6014	2	graminearum	graminearum	NNP
cord-001835-0s7ok4uw	6014	3	is	be	VBZ
cord-001835-0s7ok4uw	6014	4	a	a	DT
cord-001835-0s7ok4uw	6014	5	powerful	powerful	JJ
cord-001835-0s7ok4uw	6014	6	plant	plant	NN
cord-001835-0s7ok4uw	6014	7	pathogen	pathogen	NN
cord-001835-0s7ok4uw	6014	8	and	and	CC
cord-001835-0s7ok4uw	6014	9	infects	infect	VBZ
cord-001835-0s7ok4uw	6014	10	major	major	JJ
cord-001835-0s7ok4uw	6014	11	crop	crop	NN
cord-001835-0s7ok4uw	6014	12	plants	plant	NNS
cord-001835-0s7ok4uw	6014	13	around	around	IN
cord-001835-0s7ok4uw	6014	14	the	the	DT
cord-001835-0s7ok4uw	6014	15	world	world	NN
cord-001835-0s7ok4uw	6014	16	.	.	.
cord-001835-0s7ok4uw	6015	1	Acute	acute	JJ
cord-001835-0s7ok4uw	6015	2	toxicity	toxicity	NN
cord-001835-0s7ok4uw	6015	3	of	of	IN
cord-001835-0s7ok4uw	6015	4	zearalenone	zearalenone	NN
cord-001835-0s7ok4uw	6015	5	is	be	VBZ
cord-001835-0s7ok4uw	6015	6	low	low	JJ
cord-001835-0s7ok4uw	6015	7	,	,	,
cord-001835-0s7ok4uw	6015	8	but	but	CC
cord-001835-0s7ok4uw	6015	9	due	due	IN
cord-001835-0s7ok4uw	6015	10	to	to	IN
cord-001835-0s7ok4uw	6015	11	its	-PRON-	PRP$
cord-001835-0s7ok4uw	6015	12	structural	structural	JJ
cord-001835-0s7ok4uw	6015	13	similarity	similarity	NN
cord-001835-0s7ok4uw	6015	14	to	to	IN
cord-001835-0s7ok4uw	6015	15	b	b	NN
cord-001835-0s7ok4uw	6015	16	-	-	HYPH
cord-001835-0s7ok4uw	6015	17	estradiol	estradiol	NN
cord-001835-0s7ok4uw	6015	18	it	-PRON-	PRP
cord-001835-0s7ok4uw	6015	19	has	have	VBZ
cord-001835-0s7ok4uw	6015	20	binding	bind	VBG
cord-001835-0s7ok4uw	6015	21	affinity	affinity	NN
cord-001835-0s7ok4uw	6015	22	to	to	IN
cord-001835-0s7ok4uw	6015	23	the	the	DT
cord-001835-0s7ok4uw	6015	24	estrogen	estrogen	NN
cord-001835-0s7ok4uw	6015	25	receptor	receptor	NN
cord-001835-0s7ok4uw	6015	26	,	,	,
cord-001835-0s7ok4uw	6015	27	which	which	WDT
cord-001835-0s7ok4uw	6015	28	results	result	VBZ
cord-001835-0s7ok4uw	6015	29	in	in	IN
cord-001835-0s7ok4uw	6015	30	interference	interference	NN
cord-001835-0s7ok4uw	6015	31	with	with	IN
cord-001835-0s7ok4uw	6015	32	hormonal	hormonal	JJ
cord-001835-0s7ok4uw	6015	33	balance	balance	NN
cord-001835-0s7ok4uw	6015	34	.	.	.
cord-001835-0s7ok4uw	6016	1	Typical	typical	JJ
cord-001835-0s7ok4uw	6016	2	effects	effect	NNS
cord-001835-0s7ok4uw	6016	3	seen	see	VBN
cord-001835-0s7ok4uw	6016	4	in	in	IN
cord-001835-0s7ok4uw	6016	5	animals	animal	NNS
cord-001835-0s7ok4uw	6016	6	include	include	VBP
cord-001835-0s7ok4uw	6016	7	symptoms	symptom	NNS
cord-001835-0s7ok4uw	6016	8	like	like	IN
cord-001835-0s7ok4uw	6016	9	hyperestrogenism	hyperestrogenism	NN
cord-001835-0s7ok4uw	6016	10	and	and	CC
cord-001835-0s7ok4uw	6016	11	reproductive	reproductive	JJ
cord-001835-0s7ok4uw	6016	12	disorders	disorder	NNS
cord-001835-0s7ok4uw	6016	13	(	(	-LRB-
cord-001835-0s7ok4uw	6016	14	reduced	reduce	VBN
cord-001835-0s7ok4uw	6016	15	fertility	fertility	NN
cord-001835-0s7ok4uw	6016	16	,	,	,
cord-001835-0s7ok4uw	6016	17	reduced	reduce	VBN
cord-001835-0s7ok4uw	6016	18	litter	litter	NN
cord-001835-0s7ok4uw	6016	19	size	size	NN
cord-001835-0s7ok4uw	6016	20	or	or	CC
cord-001835-0s7ok4uw	6016	21	swelling	swelling	NN
cord-001835-0s7ok4uw	6016	22	of	of	IN
cord-001835-0s7ok4uw	6016	23	uterus	uterus	NN
cord-001835-0s7ok4uw	6016	24	and	and	CC
cord-001835-0s7ok4uw	6016	25	vulva	vulva	NN
cord-001835-0s7ok4uw	6016	26	)	)	-RRB-
cord-001835-0s7ok4uw	6016	27	.	.	.
cord-001835-0s7ok4uw	6017	1	To	to	TO
cord-001835-0s7ok4uw	6017	2	reduce	reduce	VB
cord-001835-0s7ok4uw	6017	3	the	the	DT
cord-001835-0s7ok4uw	6017	4	risk	risk	NN
cord-001835-0s7ok4uw	6017	5	for	for	IN
cord-001835-0s7ok4uw	6017	6	human	human	JJ
cord-001835-0s7ok4uw	6017	7	and	and	CC
cord-001835-0s7ok4uw	6017	8	animal	animal	NN
cord-001835-0s7ok4uw	6017	9	health	health	NN
cord-001835-0s7ok4uw	6017	10	posed	pose	VBN
cord-001835-0s7ok4uw	6017	11	by	by	IN
cord-001835-0s7ok4uw	6017	12	the	the	DT
cord-001835-0s7ok4uw	6017	13	ingestion	ingestion	NN
cord-001835-0s7ok4uw	6017	14	of	of	IN
cord-001835-0s7ok4uw	6017	15	contaminated	contaminate	VBN
cord-001835-0s7ok4uw	6017	16	food	food	NN
cord-001835-0s7ok4uw	6017	17	or	or	CC
cord-001835-0s7ok4uw	6017	18	feed	feed	VB
cord-001835-0s7ok4uw	6017	19	different	different	JJ
cord-001835-0s7ok4uw	6017	20	decontamination	decontamination	NN
cord-001835-0s7ok4uw	6017	21	strategies	strategy	NNS
cord-001835-0s7ok4uw	6017	22	have	have	VBP
cord-001835-0s7ok4uw	6017	23	been	be	VBN
cord-001835-0s7ok4uw	6017	24	studied	study	VBN
cord-001835-0s7ok4uw	6017	25	,	,	,
cord-001835-0s7ok4uw	6017	26	including	include	VBG
cord-001835-0s7ok4uw	6017	27	biotransformation	biotransformation	NN
cord-001835-0s7ok4uw	6017	28	.	.	.
cord-001835-0s7ok4uw	6018	1	Today	today	NN
cord-001835-0s7ok4uw	6018	2	many	many	JJ
cord-001835-0s7ok4uw	6018	3	microorganisms	microorganism	NNS
cord-001835-0s7ok4uw	6018	4	are	be	VBP
cord-001835-0s7ok4uw	6018	5	known	know	VBN
cord-001835-0s7ok4uw	6018	6	to	to	TO
cord-001835-0s7ok4uw	6018	7	degrade	degrade	VB
cord-001835-0s7ok4uw	6018	8	zearalenone	zearalenone	NN
cord-001835-0s7ok4uw	6018	9	,	,	,
cord-001835-0s7ok4uw	6018	10	but	but	CC
cord-001835-0s7ok4uw	6018	11	for	for	IN
cord-001835-0s7ok4uw	6018	12	most	most	JJS
cord-001835-0s7ok4uw	6018	13	of	of	IN
cord-001835-0s7ok4uw	6018	14	them	-PRON-	PRP
cord-001835-0s7ok4uw	6018	15	the	the	DT
cord-001835-0s7ok4uw	6018	16	degradation	degradation	NN
cord-001835-0s7ok4uw	6018	17	pathway	pathway	NN
cord-001835-0s7ok4uw	6018	18	and	and	CC
cord-001835-0s7ok4uw	6018	19	formed	form	VBN
cord-001835-0s7ok4uw	6018	20	metabolites	metabolite	NNS
cord-001835-0s7ok4uw	6018	21	remained	remain	VBD
cord-001835-0s7ok4uw	6018	22	unknown	unknown	JJ
cord-001835-0s7ok4uw	6018	23	,	,	,
cord-001835-0s7ok4uw	6018	24	hence	hence	RB
cord-001835-0s7ok4uw	6018	25	it	-PRON-	PRP
cord-001835-0s7ok4uw	6018	26	is	be	VBZ
cord-001835-0s7ok4uw	6018	27	unknown	unknown	JJ
cord-001835-0s7ok4uw	6018	28	if	if	IN
cord-001835-0s7ok4uw	6018	29	this	this	DT
cord-001835-0s7ok4uw	6018	30	degradation	degradation	NN
cord-001835-0s7ok4uw	6018	31	also	also	RB
cord-001835-0s7ok4uw	6018	32	means	mean	VBZ
cord-001835-0s7ok4uw	6018	33	detoxification	detoxification	NN
cord-001835-0s7ok4uw	6018	34	.	.	.
cord-001835-0s7ok4uw	6019	1	Only	only	RB
cord-001835-0s7ok4uw	6019	2	for	for	IN
cord-001835-0s7ok4uw	6019	3	the	the	DT
cord-001835-0s7ok4uw	6019	4	fungal	fungal	NN
cord-001835-0s7ok4uw	6019	5	strains	strain	NNS
cord-001835-0s7ok4uw	6019	6	Trichosporon	Trichosporon	NNP
cord-001835-0s7ok4uw	6019	7	mycotoxinivorans	mycotoxinivoran	NNS
cord-001835-0s7ok4uw	6019	8	and	and	CC
cord-001835-0s7ok4uw	6019	9	Gliocladium	Gliocladium	NNP
cord-001835-0s7ok4uw	6019	10	roseum	roseum	JJ
cord-001835-0s7ok4uw	6019	11	ZEN	zen	NN
cord-001835-0s7ok4uw	6019	12	degradation	degradation	NN
cord-001835-0s7ok4uw	6019	13	has	have	VBZ
cord-001835-0s7ok4uw	6019	14	been	be	VBN
cord-001835-0s7ok4uw	6019	15	studied	study	VBN
cord-001835-0s7ok4uw	6019	16	in	in	IN
cord-001835-0s7ok4uw	6019	17	detail	detail	NN
cord-001835-0s7ok4uw	6019	18	and	and	CC
cord-001835-0s7ok4uw	6019	19	loss	loss	NN
cord-001835-0s7ok4uw	6019	20	of	of	IN
cord-001835-0s7ok4uw	6019	21	estrogenicity	estrogenicity	NN
cord-001835-0s7ok4uw	6019	22	of	of	IN
cord-001835-0s7ok4uw	6019	23	reaction	reaction	NN
cord-001835-0s7ok4uw	6019	24	products	product	NNS
cord-001835-0s7ok4uw	6019	25	has	have	VBZ
cord-001835-0s7ok4uw	6019	26	been	be	VBN
cord-001835-0s7ok4uw	6019	27	confirmed	confirm	VBN
cord-001835-0s7ok4uw	6019	28	.	.	.
cord-001835-0s7ok4uw	6020	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	6020	2	screened	screen	VBD
cord-001835-0s7ok4uw	6020	3	for	for	IN
cord-001835-0s7ok4uw	6020	4	,	,	,
cord-001835-0s7ok4uw	6020	5	and	and	CC
cord-001835-0s7ok4uw	6020	6	isolated	isolate	VBN
cord-001835-0s7ok4uw	6020	7	zearalenone	zearalenone	NN
cord-001835-0s7ok4uw	6020	8	degrading	degrade	VBG
cord-001835-0s7ok4uw	6020	9	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	6020	10	from	from	IN
cord-001835-0s7ok4uw	6020	11	soil	soil	NN
cord-001835-0s7ok4uw	6020	12	samples	sample	NNS
cord-001835-0s7ok4uw	6020	13	.	.	.
cord-001835-0s7ok4uw	6021	1	The	the	DT
cord-001835-0s7ok4uw	6021	2	most	most	RBS
cord-001835-0s7ok4uw	6021	3	promising	promising	JJ
cord-001835-0s7ok4uw	6021	4	new	new	JJ
cord-001835-0s7ok4uw	6021	5	bacterial	bacterial	JJ
cord-001835-0s7ok4uw	6021	6	isolate	isolate	NN
cord-001835-0s7ok4uw	6021	7	was	be	VBD
cord-001835-0s7ok4uw	6021	8	taxonomically	taxonomically	RB
cord-001835-0s7ok4uw	6021	9	assigned	assign	VBN
cord-001835-0s7ok4uw	6021	10	to	to	IN
cord-001835-0s7ok4uw	6021	11	the	the	DT
cord-001835-0s7ok4uw	6021	12	species	specie	NNS
cord-001835-0s7ok4uw	6021	13	Rhodococcus	Rhodococcus	NNP
cord-001835-0s7ok4uw	6021	14	erythropolis	erythropoli	VBD
cord-001835-0s7ok4uw	6021	15	and	and	CC
cord-001835-0s7ok4uw	6021	16	designated	designate	VBD
cord-001835-0s7ok4uw	6021	17	PFA	PFA	NNP
cord-001835-0s7ok4uw	6021	18	D8	D8	NNP
cord-001835-0s7ok4uw	6021	19	-	-	HYPH
cord-001835-0s7ok4uw	6021	20	1	1	CD
cord-001835-0s7ok4uw	6021	21	.	.	.
cord-001835-0s7ok4uw	6022	1	The	the	DT
cord-001835-0s7ok4uw	6022	2	zearalenone	zearalenone	NN
cord-001835-0s7ok4uw	6022	3	catabolism	catabolism	NN
cord-001835-0s7ok4uw	6022	4	pathway	pathway	NN
cord-001835-0s7ok4uw	6022	5	of	of	IN
cord-001835-0s7ok4uw	6022	6	PFA	PFA	NNP
cord-001835-0s7ok4uw	6022	7	D8	D8	NNP
cord-001835-0s7ok4uw	6022	8	-	-	HYPH
cord-001835-0s7ok4uw	6022	9	1	1	NNP
cord-001835-0s7ok4uw	6022	10	was	be	VBD
cord-001835-0s7ok4uw	6022	11	found	find	VBN
cord-001835-0s7ok4uw	6022	12	to	to	TO
cord-001835-0s7ok4uw	6022	13	be	be	VB
cord-001835-0s7ok4uw	6022	14	identical	identical	JJ
cord-001835-0s7ok4uw	6022	15	as	as	IN
cord-001835-0s7ok4uw	6022	16	known	know	VBN
cord-001835-0s7ok4uw	6022	17	from	from	IN
cord-001835-0s7ok4uw	6022	18	G.	G.	NNP
cord-001835-0s7ok4uw	6022	19	roseum	roseum	NNP
cord-001835-0s7ok4uw	6022	20	.	.	.
cord-001835-0s7ok4uw	6023	1	The	the	DT
cord-001835-0s7ok4uw	6023	2	primary	primary	JJ
cord-001835-0s7ok4uw	6023	3	reaction	reaction	NN
cord-001835-0s7ok4uw	6023	4	product	product	NN
cord-001835-0s7ok4uw	6023	5	,	,	,
cord-001835-0s7ok4uw	6023	6	hydrolysed	hydrolysed	JJ
cord-001835-0s7ok4uw	6023	7	zearalenone	zearalenone	NN
cord-001835-0s7ok4uw	6023	8	,	,	,
cord-001835-0s7ok4uw	6023	9	has	have	VBZ
cord-001835-0s7ok4uw	6023	10	so	so	RB
cord-001835-0s7ok4uw	6023	11	far	far	RB
cord-001835-0s7ok4uw	6023	12	only	only	RB
cord-001835-0s7ok4uw	6023	13	been	be	VBN
cord-001835-0s7ok4uw	6023	14	postulated	postulate	VBN
cord-001835-0s7ok4uw	6023	15	in	in	IN
cord-001835-0s7ok4uw	6023	16	G.	G.	NNP
cord-001835-0s7ok4uw	6023	17	roseum	roseum	NN
cord-001835-0s7ok4uw	6023	18	.	.	.
cord-001835-0s7ok4uw	6024	1	We	-PRON-	PRP
cord-001835-0s7ok4uw	6024	2	prepared	prepare	VBD
cord-001835-0s7ok4uw	6024	3	hydrolysed	hydrolysed	JJ
cord-001835-0s7ok4uw	6024	4	zearalenone	zearalenone	NN
cord-001835-0s7ok4uw	6024	5	by	by	IN
cord-001835-0s7ok4uw	6024	6	preparative	preparative	JJ
cord-001835-0s7ok4uw	6024	7	HPLC	HPLC	NNP
cord-001835-0s7ok4uw	6024	8	and	and	CC
cord-001835-0s7ok4uw	6024	9	showed	show	VBD
cord-001835-0s7ok4uw	6024	10	loss	loss	NN
cord-001835-0s7ok4uw	6024	11	of	of	IN
cord-001835-0s7ok4uw	6024	12	estrogenicity	estrogenicity	NN
cord-001835-0s7ok4uw	6024	13	in	in	IN
cord-001835-0s7ok4uw	6024	14	assays	assay	NNS
cord-001835-0s7ok4uw	6024	15	with	with	IN
cord-001835-0s7ok4uw	6024	16	the	the	DT
cord-001835-0s7ok4uw	6024	17	breast	breast	NN
cord-001835-0s7ok4uw	6024	18	cancer	cancer	NN
cord-001835-0s7ok4uw	6024	19	cell	cell	NN
cord-001835-0s7ok4uw	6024	20	line	line	NN
cord-001835-0s7ok4uw	6024	21	MCF7	MCF7	NNP
cord-001835-0s7ok4uw	6024	22	and	and	CC
cord-001835-0s7ok4uw	6024	23	the	the	DT
cord-001835-0s7ok4uw	6024	24	estrogen	estrogen	NN
cord-001835-0s7ok4uw	6024	25	reporter	reporter	NN
cord-001835-0s7ok4uw	6024	26	yeast	yeast	NN
cord-001835-0s7ok4uw	6024	27	strain	strain	VBP
cord-001835-0s7ok4uw	6024	28	YZHB817	YZHB817	NNP
cord-001835-0s7ok4uw	6024	29	.	.	.
cord-001835-0s7ok4uw	6025	1	A	a	DT
cord-001835-0s7ok4uw	6025	2	genomic	genomic	JJ
cord-001835-0s7ok4uw	6025	3	library	library	NN
cord-001835-0s7ok4uw	6025	4	was	be	VBD
cord-001835-0s7ok4uw	6025	5	prepared	prepare	VBN
cord-001835-0s7ok4uw	6025	6	and	and	CC
cord-001835-0s7ok4uw	6025	7	screened	screen	VBN
cord-001835-0s7ok4uw	6025	8	in	in	IN
cord-001835-0s7ok4uw	6025	9	zearalenone	zearalenone	NN
cord-001835-0s7ok4uw	6025	10	degradation	degradation	NN
cord-001835-0s7ok4uw	6025	11	deficient	deficient	JJ
cord-001835-0s7ok4uw	6026	1	R.	R.	NNP
cord-001835-0s7ok4uw	6026	2	erythropolis	erythropoli	VBD
cord-001835-0s7ok4uw	6026	3	PR4	PR4	NNP
cord-001835-0s7ok4uw	6026	4	.	.	.
cord-001835-0s7ok4uw	6027	1	The	the	DT
cord-001835-0s7ok4uw	6027	2	gene	gene	NN
cord-001835-0s7ok4uw	6027	3	encoding	encode	VBG
cord-001835-0s7ok4uw	6027	4	zearalenone	zearalenone	NNP
cord-001835-0s7ok4uw	6027	5	hydrolase	hydrolase	NNP
cord-001835-0s7ok4uw	6027	6	was	be	VBD
cord-001835-0s7ok4uw	6027	7	found	find	VBN
cord-001835-0s7ok4uw	6027	8	and	and	CC
cord-001835-0s7ok4uw	6027	9	named	name	VBN
cord-001835-0s7ok4uw	6027	10	zenA.	zenA.	NNP
cord-001835-0s7ok4uw	6028	1	The	the	DT
cord-001835-0s7ok4uw	6028	2	hydrolase	hydrolase	NN
cord-001835-0s7ok4uw	6028	3	was	be	VBD
cord-001835-0s7ok4uw	6028	4	identified	identify	VBN
cord-001835-0s7ok4uw	6028	5	as	as	IN
cord-001835-0s7ok4uw	6028	6	member	member	NN
cord-001835-0s7ok4uw	6028	7	of	of	IN
cord-001835-0s7ok4uw	6028	8	the	the	DT
cord-001835-0s7ok4uw	6028	9	a	a	NNP
cord-001835-0s7ok4uw	6028	10	/	/	SYM
cord-001835-0s7ok4uw	6028	11	b	b	NN
cord-001835-0s7ok4uw	6028	12	-	-	HYPH
cord-001835-0s7ok4uw	6028	13	hydrolase	hydrolase	NN
cord-001835-0s7ok4uw	6028	14	family	family	NN
cord-001835-0s7ok4uw	6028	15	and	and	CC
cord-001835-0s7ok4uw	6028	16	named	name	VBN
cord-001835-0s7ok4uw	6028	17	ZenA.	ZenA.	.
cord-001835-0s7ok4uw	6029	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	6029	2	was	be	VBD
cord-001835-0s7ok4uw	6029	3	cloned	clone	VBN
cord-001835-0s7ok4uw	6029	4	,	,	,
cord-001835-0s7ok4uw	6029	5	recombinantly	recombinantly	RB
cord-001835-0s7ok4uw	6029	6	expressed	express	VBN
cord-001835-0s7ok4uw	6029	7	in	in	IN
cord-001835-0s7ok4uw	6029	8	E.	E.	NNP
cord-001835-0s7ok4uw	6029	9	coli	coli	NNS
cord-001835-0s7ok4uw	6029	10	and	and	CC
cord-001835-0s7ok4uw	6029	11	purified	purify	VBN
cord-001835-0s7ok4uw	6029	12	by	by	IN
cord-001835-0s7ok4uw	6029	13	6	6	CD
cord-001835-0s7ok4uw	6029	14	x	x	SYM
cord-001835-0s7ok4uw	6029	15	His	-PRON-	PRP$
cord-001835-0s7ok4uw	6029	16	-	-	HYPH
cord-001835-0s7ok4uw	6029	17	tag	tag	NN
cord-001835-0s7ok4uw	6029	18	mediated	mediate	VBN
cord-001835-0s7ok4uw	6029	19	immobilised	immobilised	JJ
cord-001835-0s7ok4uw	6029	20	metal	metal	NN
cord-001835-0s7ok4uw	6029	21	affinity	affinity	NN
cord-001835-0s7ok4uw	6029	22	chromatography	chromatography	NN
cord-001835-0s7ok4uw	6029	23	.	.	.
cord-001835-0s7ok4uw	6030	1	Activity	activity	NN
cord-001835-0s7ok4uw	6030	2	of	of	IN
cord-001835-0s7ok4uw	6030	3	His	-PRON-	PRP$
cord-001835-0s7ok4uw	6030	4	-	-	HYPH
cord-001835-0s7ok4uw	6030	5	tagged	tag	VBN
cord-001835-0s7ok4uw	6030	6	and	and	CC
cord-001835-0s7ok4uw	6030	7	untagged	untagged	JJ
cord-001835-0s7ok4uw	6030	8	enzyme	enzyme	NN
cord-001835-0s7ok4uw	6030	9	ZenA	ZenA	NNP
cord-001835-0s7ok4uw	6030	10	was	be	VBD
cord-001835-0s7ok4uw	6030	11	compared	compare	VBN
cord-001835-0s7ok4uw	6030	12	in	in	IN
cord-001835-0s7ok4uw	6030	13	cleared	clear	VBN
cord-001835-0s7ok4uw	6030	14	lysate	lysate	NN
cord-001835-0s7ok4uw	6030	15	and	and	CC
cord-001835-0s7ok4uw	6030	16	ZenA	ZenA	NNP
cord-001835-0s7ok4uw	6030	17	was	be	VBD
cord-001835-0s7ok4uw	6030	18	purified	purify	VBN
cord-001835-0s7ok4uw	6030	19	for	for	IN
cord-001835-0s7ok4uw	6030	20	enzyme	enzyme	NN
cord-001835-0s7ok4uw	6030	21	characterisation	characterisation	NN
cord-001835-0s7ok4uw	6030	22	.	.	.
cord-001835-0s7ok4uw	6031	1	The	the	DT
cord-001835-0s7ok4uw	6031	2	influence	influence	NN
cord-001835-0s7ok4uw	6031	3	of	of	IN
cord-001835-0s7ok4uw	6031	4	pH	ph	NN
cord-001835-0s7ok4uw	6031	5	and	and	CC
cord-001835-0s7ok4uw	6031	6	temperature	temperature	NN
cord-001835-0s7ok4uw	6031	7	on	on	IN
cord-001835-0s7ok4uw	6031	8	enzyme	enzyme	NN
cord-001835-0s7ok4uw	6031	9	activity	activity	NN
cord-001835-0s7ok4uw	6031	10	and	and	CC
cord-001835-0s7ok4uw	6031	11	stability	stability	NN
cord-001835-0s7ok4uw	6031	12	was	be	VBD
cord-001835-0s7ok4uw	6031	13	evaluated	evaluate	VBN
cord-001835-0s7ok4uw	6031	14	and	and	CC
cord-001835-0s7ok4uw	6031	15	kinetic	kinetic	JJ
cord-001835-0s7ok4uw	6031	16	parameters	parameter	NNS
cord-001835-0s7ok4uw	6031	17	were	be	VBD
cord-001835-0s7ok4uw	6031	18	determined	determine	VBN
cord-001835-0s7ok4uw	6031	19	.	.	.
cord-001835-0s7ok4uw	6032	1	A	a	DT
cord-001835-0s7ok4uw	6032	2	new	new	JJ
cord-001835-0s7ok4uw	6032	3	biding	biding	NN
cord-001835-0s7ok4uw	6032	4	site	site	NN
cord-001835-0s7ok4uw	6032	5	for	for	IN
cord-001835-0s7ok4uw	6032	6	snake	snake	NN
cord-001835-0s7ok4uw	6032	7	venom	venom	NN
cord-001835-0s7ok4uw	6032	8	C	c	NN
cord-001835-0s7ok4uw	6032	9	-	-	HYPH
cord-001835-0s7ok4uw	6032	10	type	type	NN
cord-001835-0s7ok4uw	6032	11	lectins?Maria	lectins?maria	FW
cord-001835-0s7ok4uw	6032	12	Cristina	Cristina	NNP
cord-001835-0s7ok4uw	6032	13	Nonato	Nonato	NNP
cord-001835-0s7ok4uw	6032	14	Costa	Costa	NNP
cord-001835-0s7ok4uw	6032	15	1	1	CD
cord-001835-0s7ok4uw	6032	16	,	,	,
cord-001835-0s7ok4uw	6032	17	Ricardo	Ricardo	NNP
cord-001835-0s7ok4uw	6032	18	Augusto	Augusto	NNP
cord-001835-0s7ok4uw	6032	19	Pereira	Pereira	NNP
cord-001835-0s7ok4uw	6032	20	de	de	NNP
cord-001835-0s7ok4uw	6032	21	P	P	NNP
cord-001835-0s7ok4uw	6032	22	adua	adua	NNP
cord-001835-0s7ok4uw	6032	23	1	1	CD
cord-001835-0s7ok4uw	6032	24	,	,	,
cord-001835-0s7ok4uw	6032	25	Marco	Marco	NNP
cord-001835-0s7ok4uw	6032	26	Aurelio	Aurelio	NNP
cord-001835-0s7ok4uw	6032	27	Sartim	Sartim	NNP
cord-001835-0s7ok4uw	6032	28	1	1	CD
cord-001835-0s7ok4uw	6032	29	,	,	,
cord-001835-0s7ok4uw	6033	1	Suely	suely	RB
cord-001835-0s7ok4uw	6033	2	Vilela	Vilela	NNP
cord-001835-0s7ok4uw	6033	3	Sampaio	Sampaio	NNP
cord-001835-0s7ok4uw	6033	4	1	1	CD
cord-001835-0s7ok4uw	6033	5	1	1	CD
cord-001835-0s7ok4uw	6033	6	University	University	NNP
cord-001835-0s7ok4uw	6033	7	of	of	IN
cord-001835-0s7ok4uw	6033	8	São	São	NNP
cord-001835-0s7ok4uw	6033	9	Paulo	Paulo	NNP
cord-001835-0s7ok4uw	6033	10	,	,	,
cord-001835-0s7ok4uw	6033	11	FCFRP	FCFRP	NNP
cord-001835-0s7ok4uw	6033	12	C	C	NNP
cord-001835-0s7ok4uw	6033	13	-	-	HYPH
cord-001835-0s7ok4uw	6033	14	type	type	NN
cord-001835-0s7ok4uw	6033	15	lectins	lectin	NNS
cord-001835-0s7ok4uw	6033	16	are	be	VBP
cord-001835-0s7ok4uw	6033	17	proteins	protein	NNS
cord-001835-0s7ok4uw	6033	18	that	that	WDT
cord-001835-0s7ok4uw	6033	19	bind	bind	VBP
cord-001835-0s7ok4uw	6033	20	different	different	JJ
cord-001835-0s7ok4uw	6033	21	glycan	glycan	NN
cord-001835-0s7ok4uw	6033	22	molecules	molecule	NNS
cord-001835-0s7ok4uw	6033	23	by	by	IN
cord-001835-0s7ok4uw	6033	24	interactions	interaction	NNS
cord-001835-0s7ok4uw	6033	25	with	with	IN
cord-001835-0s7ok4uw	6033	26	a	a	DT
cord-001835-0s7ok4uw	6033	27	calcium	calcium	NN
cord-001835-0s7ok4uw	6033	28	atom	atom	NN
cord-001835-0s7ok4uw	6033	29	present	present	NN
cord-001835-0s7ok4uw	6033	30	in	in	IN
cord-001835-0s7ok4uw	6033	31	a	a	DT
cord-001835-0s7ok4uw	6033	32	carbohydrate	carbohydrate	NN
cord-001835-0s7ok4uw	6033	33	recognition	recognition	NN
cord-001835-0s7ok4uw	6033	34	domain	domain	NN
cord-001835-0s7ok4uw	6033	35	(	(	-LRB-
cord-001835-0s7ok4uw	6033	36	CRD	CRD	NNP
cord-001835-0s7ok4uw	6033	37	)	)	-RRB-
cord-001835-0s7ok4uw	6033	38	.	.	.
cord-001835-0s7ok4uw	6034	1	Many	many	JJ
cord-001835-0s7ok4uw	6034	2	organisms	organism	NNS
cord-001835-0s7ok4uw	6034	3	(	(	-LRB-
cord-001835-0s7ok4uw	6034	4	plants	plant	NNS
cord-001835-0s7ok4uw	6034	5	,	,	,
cord-001835-0s7ok4uw	6034	6	bacteria	bacteria	NNS
cord-001835-0s7ok4uw	6034	7	,	,	,
cord-001835-0s7ok4uw	6034	8	virus	virus	NN
cord-001835-0s7ok4uw	6034	9	and	and	CC
cord-001835-0s7ok4uw	6034	10	animals	animal	NNS
cord-001835-0s7ok4uw	6034	11	)	)	-RRB-
cord-001835-0s7ok4uw	6034	12	use	use	VBP
cord-001835-0s7ok4uw	6034	13	these	these	DT
cord-001835-0s7ok4uw	6034	14	proteins	protein	NNS
cord-001835-0s7ok4uw	6034	15	in	in	IN
cord-001835-0s7ok4uw	6034	16	various	various	JJ
cord-001835-0s7ok4uw	6034	17	biological	biological	JJ
cord-001835-0s7ok4uw	6034	18	events	event	NNS
cord-001835-0s7ok4uw	6034	19	like	like	IN
cord-001835-0s7ok4uw	6034	20	lymphocyte	lymphocyte	NN
cord-001835-0s7ok4uw	6034	21	adhesion	adhesion	NN
cord-001835-0s7ok4uw	6034	22	,	,	,
cord-001835-0s7ok4uw	6034	23	erythrocyte	erythrocyte	NN
cord-001835-0s7ok4uw	6034	24	agglutination	agglutination	NN
cord-001835-0s7ok4uw	6034	25	and	and	CC
cord-001835-0s7ok4uw	6034	26	extracellular	extracellular	JJ
cord-001835-0s7ok4uw	6034	27	matrix	matrix	NN
cord-001835-0s7ok4uw	6034	28	organization	organization	NN
cord-001835-0s7ok4uw	6034	29	.	.	.
cord-001835-0s7ok4uw	6035	1	The	the	DT
cord-001835-0s7ok4uw	6035	2	C	c	NN
cord-001835-0s7ok4uw	6035	3	-	-	HYPH
cord-001835-0s7ok4uw	6035	4	type	type	NN
cord-001835-0s7ok4uw	6035	5	lectin	lectin	NN
cord-001835-0s7ok4uw	6035	6	fold	fold	NN
cord-001835-0s7ok4uw	6035	7	is	be	VBZ
cord-001835-0s7ok4uw	6035	8	plastic	plastic	JJ
cord-001835-0s7ok4uw	6035	9	and	and	CC
cord-001835-0s7ok4uw	6035	10	possible	possible	JJ
cord-001835-0s7ok4uw	6035	11	for	for	IN
cord-001835-0s7ok4uw	6035	12	about	about	RB
cord-001835-0s7ok4uw	6035	13	1013	1013	CD
cord-001835-0s7ok4uw	6035	14	different	different	JJ
cord-001835-0s7ok4uw	6035	15	sequences	sequence	NNS
cord-001835-0s7ok4uw	6035	16	,	,	,
cord-001835-0s7ok4uw	6035	17	what	what	WP
cord-001835-0s7ok4uw	6035	18	promoted	promote	VBD
cord-001835-0s7ok4uw	6035	19	its	-PRON-	PRP$
cord-001835-0s7ok4uw	6035	20	adaptation	adaptation	NN
cord-001835-0s7ok4uw	6035	21	to	to	IN
cord-001835-0s7ok4uw	6035	22	diverse	diverse	JJ
cord-001835-0s7ok4uw	6035	23	functions	function	NNS
cord-001835-0s7ok4uw	6035	24	,	,	,
cord-001835-0s7ok4uw	6035	25	similarly	similarly	RB
cord-001835-0s7ok4uw	6035	26	to	to	IN
cord-001835-0s7ok4uw	6035	27	the	the	DT
cord-001835-0s7ok4uw	6035	28	observed	observed	JJ
cord-001835-0s7ok4uw	6035	29	for	for	IN
cord-001835-0s7ok4uw	6035	30	the	the	DT
cord-001835-0s7ok4uw	6035	31	immunoglobulin	immunoglobulin	NN
cord-001835-0s7ok4uw	6035	32	fold	fold	NN
cord-001835-0s7ok4uw	6035	33	(	(	-LRB-
cord-001835-0s7ok4uw	6035	34	1014	1014	CD
cord-001835-0s7ok4uw	6035	35	-	-	SYM
cord-001835-0s7ok4uw	6035	36	1016	1016	CD
cord-001835-0s7ok4uw	6035	37	sequences	sequence	NNS
cord-001835-0s7ok4uw	6035	38	)	)	-RRB-
cord-001835-0s7ok4uw	6035	39	.	.	.
cord-001835-0s7ok4uw	6036	1	It	-PRON-	PRP
cord-001835-0s7ok4uw	6036	2	is	be	VBZ
cord-001835-0s7ok4uw	6036	3	comprised	comprise	VBN
cord-001835-0s7ok4uw	6036	4	of	of	IN
cord-001835-0s7ok4uw	6036	5	about	about	RB
cord-001835-0s7ok4uw	6036	6	110	110	CD
cord-001835-0s7ok4uw	6036	7	-	-	SYM
cord-001835-0s7ok4uw	6036	8	130	130	CD
cord-001835-0s7ok4uw	6036	9	amino	amino	NN
cord-001835-0s7ok4uw	6036	10	acid	acid	NN
cord-001835-0s7ok4uw	6036	11	residues	residue	NNS
cord-001835-0s7ok4uw	6036	12	that	that	WDT
cord-001835-0s7ok4uw	6036	13	folds	fold	VBZ
cord-001835-0s7ok4uw	6036	14	in	in	IN
cord-001835-0s7ok4uw	6036	15	two	two	CD
cord-001835-0s7ok4uw	6036	16	fourstranded	fourstranded	JJ
cord-001835-0s7ok4uw	6036	17	b	b	NN
cord-001835-0s7ok4uw	6036	18	sheets	sheet	NNS
cord-001835-0s7ok4uw	6036	19	sandwiched	sandwich	VBN
cord-001835-0s7ok4uw	6036	20	by	by	IN
cord-001835-0s7ok4uw	6036	21	two	two	CD
cord-001835-0s7ok4uw	6036	22	alpha	alpha	NN
cord-001835-0s7ok4uw	6036	23	helices	helix	NNS
cord-001835-0s7ok4uw	6036	24	.	.	.
cord-001835-0s7ok4uw	6037	1	Interestingly	interestingly	RB
cord-001835-0s7ok4uw	6037	2	,	,	,
cord-001835-0s7ok4uw	6037	3	C	c	NN
cord-001835-0s7ok4uw	6037	4	-	-	HYPH
cord-001835-0s7ok4uw	6037	5	type	type	NN
cord-001835-0s7ok4uw	6037	6	lectins	lectin	NNS
cord-001835-0s7ok4uw	6037	7	present	present	JJ
cord-001835-0s7ok4uw	6037	8	in	in	IN
cord-001835-0s7ok4uw	6037	9	snake	snake	NN
cord-001835-0s7ok4uw	6037	10	venoms	venom	NNS
cord-001835-0s7ok4uw	6037	11	are	be	VBP
cord-001835-0s7ok4uw	6037	12	possible	possible	JJ
cord-001835-0s7ok4uw	6037	13	anti	anti	JJ
cord-001835-0s7ok4uw	6037	14	-	-	JJ
cord-001835-0s7ok4uw	6037	15	cancer	cancer	JJ
cord-001835-0s7ok4uw	6037	16	agents	agent	NNS
cord-001835-0s7ok4uw	6037	17	since	since	IN
cord-001835-0s7ok4uw	6037	18	they	-PRON-	PRP
cord-001835-0s7ok4uw	6037	19	are	be	VBP
cord-001835-0s7ok4uw	6037	20	toxic	toxic	JJ
cord-001835-0s7ok4uw	6037	21	to	to	IN
cord-001835-0s7ok4uw	6037	22	cancer	cancer	NN
cord-001835-0s7ok4uw	6037	23	cells	cell	NNS
cord-001835-0s7ok4uw	6037	24	and	and	CC
cord-001835-0s7ok4uw	6037	25	inhibit	inhibit	VB
cord-001835-0s7ok4uw	6037	26	the	the	DT
cord-001835-0s7ok4uw	6037	27	adhesion	adhesion	NN
cord-001835-0s7ok4uw	6037	28	and	and	CC
cord-001835-0s7ok4uw	6037	29	proliferation	proliferation	NN
cord-001835-0s7ok4uw	6037	30	of	of	IN
cord-001835-0s7ok4uw	6037	31	various	various	JJ
cord-001835-0s7ok4uw	6037	32	cancer	cancer	NN
cord-001835-0s7ok4uw	6037	33	cell	cell	NN
cord-001835-0s7ok4uw	6037	34	lines	line	NNS
cord-001835-0s7ok4uw	6037	35	.	.	.
cord-001835-0s7ok4uw	6038	1	Therefore	therefore	RB
cord-001835-0s7ok4uw	6038	2	,	,	,
cord-001835-0s7ok4uw	6038	3	we	-PRON-	PRP
cord-001835-0s7ok4uw	6038	4	have	have	VBP
cord-001835-0s7ok4uw	6038	5	purified	purify	VBN
cord-001835-0s7ok4uw	6038	6	a	a	DT
cord-001835-0s7ok4uw	6038	7	lactose	lactose	NN
cord-001835-0s7ok4uw	6038	8	binding	bind	VBG
cord-001835-0s7ok4uw	6038	9	C	c	NN
cord-001835-0s7ok4uw	6038	10	-	-	HYPH
cord-001835-0s7ok4uw	6038	11	type	type	NN
cord-001835-0s7ok4uw	6038	12	lectin	lectin	NN
cord-001835-0s7ok4uw	6038	13	from	from	IN
cord-001835-0s7ok4uw	6038	14	the	the	DT
cord-001835-0s7ok4uw	6038	15	venom	venom	NN
cord-001835-0s7ok4uw	6038	16	of	of	IN
cord-001835-0s7ok4uw	6038	17	Bothrops	Bothrops	NNP
cord-001835-0s7ok4uw	6038	18	jararacussu	jararacussu	NN
cord-001835-0s7ok4uw	6038	19	(	(	-LRB-
cord-001835-0s7ok4uw	6038	20	BJcuL	BJcuL	NNP
cord-001835-0s7ok4uw	6038	21	)	)	-RRB-
cord-001835-0s7ok4uw	6038	22	to	to	TO
cord-001835-0s7ok4uw	6038	23	study	study	VB
cord-001835-0s7ok4uw	6038	24	its	-PRON-	PRP$
cord-001835-0s7ok4uw	6038	25	structure	structure	NN
cord-001835-0s7ok4uw	6038	26	and	and	CC
cord-001835-0s7ok4uw	6038	27	binding	bind	VBG
cord-001835-0s7ok4uw	6038	28	properties	property	NNS
cord-001835-0s7ok4uw	6038	29	to	to	IN
cord-001835-0s7ok4uw	6038	30	different	different	JJ
cord-001835-0s7ok4uw	6038	31	sugars	sugar	NNS
cord-001835-0s7ok4uw	6038	32	.	.	.
cord-001835-0s7ok4uw	6039	1	BJcuL	bjcul	NN
cord-001835-0s7ok4uw	6039	2	crystals	crystal	NNS
cord-001835-0s7ok4uw	6039	3	were	be	VBD
cord-001835-0s7ok4uw	6039	4	obtained	obtain	VBN
cord-001835-0s7ok4uw	6039	5	by	by	IN
cord-001835-0s7ok4uw	6039	6	vapor	vapor	NN
cord-001835-0s7ok4uw	6039	7	diffusion	diffusion	NN
cord-001835-0s7ok4uw	6039	8	and	and	CC
cord-001835-0s7ok4uw	6039	9	the	the	DT
cord-001835-0s7ok4uw	6039	10	structure	structure	NN
cord-001835-0s7ok4uw	6039	11	solved	solve	VBN
cord-001835-0s7ok4uw	6039	12	by	by	IN
cord-001835-0s7ok4uw	6039	13	X	x	NN
cord-001835-0s7ok4uw	6039	14	-	-	NN
cord-001835-0s7ok4uw	6039	15	ray	ray	JJ
cord-001835-0s7ok4uw	6039	16	crystallography	crystallography	NN
cord-001835-0s7ok4uw	6039	17	to	to	IN
cord-001835-0s7ok4uw	6039	18	2.9	2.9	CD
cord-001835-0s7ok4uw	6039	19	Å	å	NN
cord-001835-0s7ok4uw	6039	20	resolution	resolution	NN
cord-001835-0s7ok4uw	6039	21	.	.	.
cord-001835-0s7ok4uw	6040	1	BJcuL	BJcuL	NNP
cord-001835-0s7ok4uw	6040	2	structure	structure	NN
cord-001835-0s7ok4uw	6040	3	is	be	VBZ
cord-001835-0s7ok4uw	6040	4	a	a	DT
cord-001835-0s7ok4uw	6040	5	decamer	decamer	NN
cord-001835-0s7ok4uw	6040	6	formed	form	VBN
cord-001835-0s7ok4uw	6040	7	by	by	IN
cord-001835-0s7ok4uw	6040	8	a	a	DT
cord-001835-0s7ok4uw	6040	9	pseudo	pseudo	JJ
cord-001835-0s7ok4uw	6040	10	fivefold	fivefold	JJ
cord-001835-0s7ok4uw	6040	11	axis	axis	NN
cord-001835-0s7ok4uw	6040	12	rotation	rotation	NN
cord-001835-0s7ok4uw	6040	13	of	of	IN
cord-001835-0s7ok4uw	6040	14	a	a	DT
cord-001835-0s7ok4uw	6040	15	dimer	dimer	NN
cord-001835-0s7ok4uw	6040	16	hold	hold	NN
cord-001835-0s7ok4uw	6040	17	by	by	IN
cord-001835-0s7ok4uw	6040	18	a	a	DT
cord-001835-0s7ok4uw	6040	19	disulfide	disulfide	JJ
cord-001835-0s7ok4uw	6040	20	bond	bond	NN
cord-001835-0s7ok4uw	6040	21	.	.	.
cord-001835-0s7ok4uw	6041	1	Each	each	DT
cord-001835-0s7ok4uw	6041	2	monomer	monomer	NN
cord-001835-0s7ok4uw	6041	3	binds	bind	VBZ
cord-001835-0s7ok4uw	6041	4	a	a	DT
cord-001835-0s7ok4uw	6041	5	calcium	calcium	NN
cord-001835-0s7ok4uw	6041	6	atom	atom	NN
cord-001835-0s7ok4uw	6041	7	and	and	CC
cord-001835-0s7ok4uw	6041	8	possibly	possibly	RB
cord-001835-0s7ok4uw	6041	9	another	another	DT
cord-001835-0s7ok4uw	6041	10	metal	metal	NN
cord-001835-0s7ok4uw	6041	11	at	at	IN
cord-001835-0s7ok4uw	6041	12	a	a	DT
cord-001835-0s7ok4uw	6041	13	second	second	JJ
cord-001835-0s7ok4uw	6041	14	and	and	CC
cord-001835-0s7ok4uw	6041	15	opposed	opposed	JJ
cord-001835-0s7ok4uw	6041	16	binding	bind	VBG
cord-001835-0s7ok4uw	6041	17	site	site	NN
cord-001835-0s7ok4uw	6041	18	.	.	.