id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346965-0oq2n0af	Liu, Zhi-Ping	Bridging protein local structures and protein functions	2008-04-18		.txt	text/plain	14491	810	44	The characteristics between interface and noninterface portions of a protein surface, such as sequence conservation, proportions of amino acids, secondary structure, solvent accessibility and side-chain conformational entropy, are often used to distinguish the specificity of local structures relating to protein binding function. The method relies on a simplified representation of the chemical groups found in amino acid side-chains to identify functional sites from a single protein structure and a number of its sequence homologs. (2006) improved previous approaches by combining two known measures of 'functionality' in proteins, i.e. cleft volume and residue conservation, to develop a method for identifying the location of ligand-binding pockets in proteins. (2006) applied an SVM method to predict DNA-binding sites using the features including amino acid sequence, profile of evolutionary conservation of sequence positions, and low-resolution structural information. (2006) developed a method to predict both protein-protein binding site location and interface type (obligate or non-obligate) using a Bayesian network in combination with surface patch analysis.	./cache/cord-346965-0oq2n0af.txt	./txt/cord-346965-0oq2n0af.txt