id author title date pages extension mime words sentences flesch summary cache txt cord-325328-3l3jznkj Holbrook, Stephen R RNA structure: the long and the short of it 2005-05-16 .txt text/plain 3711 165 44 Structural studies and comparative sequence analyses have suggested that biological RNAs are largely modular in nature, composed primarily of conserved structural building blocks or motifs [4] of secondary (helices, and internal, external and junction loops) and tertiary (coaxial stacks, kissing hairpin loops, ribose zippers, etc.) structure. Other structures include the specificity domains of both A[17] and B-type ribonuclease P [18 ] ; RNAs corresponding to a guanine-responsive riboswitch (xpt) complexed with guanine [19 ] or hypoxanthine [20] , and an adenosine-responsive riboswitch (add) complexed with adenosine [19 ] ; a highly conserved stem-loop motif found at the 3 0 end of the genome of SARS (severe acute respiratory syndrome) virus and other coronaviruses [21 ] ; the core encapsidation signal of MMLV [2 ] ; and complexes between a high-affinity RNA aptamer and the NF-kB p50 homodimer [22] , and between the archaeal RNAbinding protein L7Ae and an RNA K-turn derived from a H/ACA small RNA [23] . ./cache/cord-325328-3l3jznkj.txt ./txt/cord-325328-3l3jznkj.txt