id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310847-63gh2tg4	Uversky, Vladimir N	The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins	2013-04-01		.txt	text/plain	19431	1043	50	5, 10, 46 In fact, in comparison with ordered proteins, IDPs/IDPRs are characterized by noticeable biases in their amino acid compositions, 5, 8, 10, [46] [47] [48] containing less of so-called "order-promoting" residues (cysteine, tryptophan, isoleucine, tyrosine, phenylalanine, leucine, histidine, valine, asparagines and methionine, which are mostly hydrophobic residues which are commonly found within the hydrophobic cores of foldable proteins) and more of "disorder-promoting" residues (lysine, glutamine, serine, glutamic acid and proline, which are mostly polar and charged residues, which are typically located at the surface of foldable proteins) (Fig. 1A) . Glutamic acid is an important functional residue of ordered proteins, where it can be involved in the formation of specific electrostatic valves inside the pores of ion channels, or can play unique catalytic roles in the active sites	./cache/cord-310847-63gh2tg4.txt	./txt/cord-310847-63gh2tg4.txt