id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-264489-h1n9ywbd	Roy, Urmi	Insight into the Structures of Interleukin-18 Systems	2020-07-31		.txt	text/plain	4347	273	52	The present study, including structural and molecular dynamics simulations, takes a close look at the structural stabilities of IL-18 and IL-18 receptor-bound ligand structures as functions of time. The results help to identify the conformational changes of the ligand due to receptor binding, as well as the structural orders of the apo and holo IL-18 protein complexes. This investigative approach assists in the proper identifications of therapeutic-targets, their structural-assemblies and consistent ligand-receptor interfacial interactions, and thus, plays a vital role in the development of new, innovative medicines (Freudenberg et al. The present simulation study examines the structural stabilities of the ligand-protein, IL-18 and IL-18 receptor (IL-18R) bound ligand structures as functions of time. We analyze here the conformational changes within the ligand-protein, due to receptor binding and, we also identify the possible structurally ordered and disordered region within the apo and holo (ligand-bound) protein complexes.	./cache/cord-264489-h1n9ywbd.txt	./txt/cord-264489-h1n9ywbd.txt