id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002490-kw8psrmz	Beniac, Daniel R.	Structure of the Ebola virus glycoprotein spike within the virion envelope at 11 Å resolution	2017-04-11		.txt	text/plain	4053	184	53	We present the structure of the surface Ebola virus (EBOV) trimeric glycoprotein (GP) spike at 11 Å resolution, in situ within the viral plasma membrane of purified virus particles. In addition, 29,976 images were selected for reference-free analysis of the half-diameter of EBOV to investigate the spatial distribution of the GP spikes, as well as the periodicity and symmetrical relationships between GP and the matrix protein VP40 in the envelope, and the underlying nucleocapsid layer (Figs 1c and S3) . The spike structure of Beniac et al imaged within the virus-like particles was somehow clipped, since this should have included the mucin-like domains: in addition, tomography was combined with single-particle analysis, which may have distorted the results 4 . The structure that we report here is based entirely on the well-accepted method of single-particle analysis using projection matching, and is broadly similar to that published of expressed GP in virus-like particles using tomography 28, 29 : there are noticeable differences in shape and size of the spike, as well as in resolution (Fig. 4) .	./cache/cord-002490-kw8psrmz.txt	./txt/cord-002490-kw8psrmz.txt