id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002015-s3tdllby	Burton, Aaron S.	The elusive quest for RNA knots	2016-02-01		.txt	text/plain	3536	187	53	2, 3 It is therefore a remarkable fact that the statistical incidence of topological entanglement in biomolecules such as proteins and DNA filaments, which are both long and compact, is substantially smaller than expected for general models of equilibrated polymers with equivalent length and packing conditions. It is accordingly plausible, as remarked by Levinthal in more general contexts, 7,8 that protein sequences have evolved to encode not only the thermodynamically-stable native fold, but also the sequence of steps leading to the native structure formation so to minimize the incidence of misfolded states, including knotted ones which would be very challenging to backtrack. It is possible that the sequence of naturally-occurring RNAs, some of which need to be efficiently translocated through biological pores, have evolved to harness folding kinetics and thermodynamics so as to minimize the incidence of various forms of selfentanglement, including knots, in their native structures.	./cache/cord-002015-s3tdllby.txt	./txt/cord-002015-s3tdllby.txt