id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302062-wqmynngg	Sierra-Hidalgo, Fernando	Large artery ischemic stroke in severe COVID-19	2020-06-27		.txt	text/plain	1145	78	48	title: Large artery ischemic stroke in severe COVID-19 Among hospitalized patients, stroke occurred a median of 5.5 days after admission (IQR 3.5-7.5). Only one patient met definite TOAST criteria for the diagnosis of large artery atherosclerotic infarction, and another one had a probably cardioembolic stroke due to preexisting atrial fibrillation (incomplete evaluation) [2] . None of the other six patients met diagnostic criteria for atherosclerotic, cardioembolic, or small vessel ischemic stroke (three with cryptogenic strokes, and three with incomplete evaluation). In this series of eight patients, although the evidence is limited by its observational nature and sample size, severe COVID-19 was associated with non-atherosclerotic, large artery ischemic strokes. If larger prospective studies confirm these observations, hypercoagulability associated with COVID-19 might be a contributory cause for large vessel ischemic stroke. Until robust evidence is available, the observation of intraarterial thrombi in the absence of significant atherosclerosis among these patients warrants consideration of individualized enhanced thromboprophylaxis for hospitalized patients with severe forms of SARS-CoV-2 infection.	./cache/cord-302062-wqmynngg.txt	./txt/cord-302062-wqmynngg.txt