id sid tid token lemma pos cord-004751-4vl0cvyq 1 1 key key NN cord-004751-4vl0cvyq 1 2 : : : cord-004751-4vl0cvyq 2 1 cord-004751 cord-004751 NN cord-004751-4vl0cvyq 2 2 - - HYPH cord-004751-4vl0cvyq 2 3 4vl0cvyq 4vl0cvyq JJ cord-004751-4vl0cvyq 2 4 authors author NNS cord-004751-4vl0cvyq 2 5 : : : cord-004751-4vl0cvyq 2 6 Mostow Mostow NNP cord-004751-4vl0cvyq 2 7 , , , cord-004751-4vl0cvyq 2 8 S. S. NNP cord-004751-4vl0cvyq 2 9 R. R. NNP cord-004751-4vl0cvyq 2 10 ; ; : cord-004751-4vl0cvyq 2 11 Tyrrell Tyrrell NNP cord-004751-4vl0cvyq 2 12 , , , cord-004751-4vl0cvyq 2 13 D. D. NNP cord-004751-4vl0cvyq 2 14 A. a. NN cord-004751-4vl0cvyq 2 15 J. J. NNP cord-004751-4vl0cvyq 3 1 title title NN cord-004751-4vl0cvyq 3 2 : : : cord-004751-4vl0cvyq 4 1 The the DT cord-004751-4vl0cvyq 4 2 behaviour behaviour NN cord-004751-4vl0cvyq 4 3 in in IN cord-004751-4vl0cvyq 4 4 vitro vitro FW cord-004751-4vl0cvyq 4 5 of of IN cord-004751-4vl0cvyq 4 6 attenuated attenuated JJ cord-004751-4vl0cvyq 4 7 recombinant recombinant JJ cord-004751-4vl0cvyq 4 8 influenza influenza NN cord-004751-4vl0cvyq 4 9 viruses virus NNS cord-004751-4vl0cvyq 4 10 date date NN cord-004751-4vl0cvyq 4 11 : : : cord-004751-4vl0cvyq 4 12 1973 1973 CD cord-004751-4vl0cvyq 4 13 journal journal NN cord-004751-4vl0cvyq 4 14 : : : cord-004751-4vl0cvyq 4 15 Arch Arch NNP cord-004751-4vl0cvyq 4 16 Gesamte Gesamte NNP cord-004751-4vl0cvyq 4 17 Virusforsch Virusforsch NNP cord-004751-4vl0cvyq 4 18 DOI DOI NNP cord-004751-4vl0cvyq 4 19 : : : cord-004751-4vl0cvyq 4 20 10.1007 10.1007 CD cord-004751-4vl0cvyq 4 21 / / SYM cord-004751-4vl0cvyq 4 22 bf01556156 bf01556156 CC cord-004751-4vl0cvyq 4 23 sha sha NNP cord-004751-4vl0cvyq 4 24 : : : cord-004751-4vl0cvyq 4 25 4b95c516405830415f1d82d50f89a50510f0bc93 4b95c516405830415f1d82d50f89a50510f0bc93 CD cord-004751-4vl0cvyq 4 26 doc_id doc_id CD cord-004751-4vl0cvyq 4 27 : : : cord-004751-4vl0cvyq 4 28 4751 4751 CD cord-004751-4vl0cvyq 4 29 cord_uid cord_uid NNS cord-004751-4vl0cvyq 4 30 : : : cord-004751-4vl0cvyq 5 1 4vl0cvyq 4vl0cvyq NNP cord-004751-4vl0cvyq 5 2 Influenza Influenza NNP cord-004751-4vl0cvyq 5 3 strains strain NNS cord-004751-4vl0cvyq 5 4 produced produce VBN cord-004751-4vl0cvyq 5 5 by by IN cord-004751-4vl0cvyq 5 6 recombination recombination NN cord-004751-4vl0cvyq 5 7 and and CC cord-004751-4vl0cvyq 5 8 tested test VBN cord-004751-4vl0cvyq 5 9 as as IN cord-004751-4vl0cvyq 5 10 possible possible JJ cord-004751-4vl0cvyq 5 11 live live JJ cord-004751-4vl0cvyq 5 12 vaccine vaccine NN cord-004751-4vl0cvyq 5 13 candidates candidate NNS cord-004751-4vl0cvyq 5 14 were be VBD cord-004751-4vl0cvyq 5 15 studied study VBN cord-004751-4vl0cvyq 5 16 in in IN cord-004751-4vl0cvyq 5 17 organ organ NN cord-004751-4vl0cvyq 5 18 cultures culture NNS cord-004751-4vl0cvyq 5 19 of of IN cord-004751-4vl0cvyq 5 20 trachea trachea NN cord-004751-4vl0cvyq 5 21 . . . cord-004751-4vl0cvyq 6 1 Two two CD cord-004751-4vl0cvyq 6 2 strains strain NNS cord-004751-4vl0cvyq 6 3 which which WDT cord-004751-4vl0cvyq 6 4 proved prove VBD cord-004751-4vl0cvyq 6 5 to to TO cord-004751-4vl0cvyq 6 6 be be VB cord-004751-4vl0cvyq 6 7 too too RB cord-004751-4vl0cvyq 6 8 virulent virulent JJ cord-004751-4vl0cvyq 6 9 in in IN cord-004751-4vl0cvyq 6 10 human human JJ cord-004751-4vl0cvyq 6 11 volunteers volunteer NNS cord-004751-4vl0cvyq 6 12 regularly regularly RB cord-004751-4vl0cvyq 6 13 caused cause VBD cord-004751-4vl0cvyq 6 14 damage damage NN cord-004751-4vl0cvyq 6 15 to to IN cord-004751-4vl0cvyq 6 16 the the DT cord-004751-4vl0cvyq 6 17 ciliated ciliated JJ cord-004751-4vl0cvyq 6 18 epithelium epithelium NN cord-004751-4vl0cvyq 6 19 and and CC cord-004751-4vl0cvyq 6 20 viruses virus NNS cord-004751-4vl0cvyq 6 21 grew grow VBD cord-004751-4vl0cvyq 6 22 to to IN cord-004751-4vl0cvyq 6 23 high high JJ cord-004751-4vl0cvyq 6 24 titre titre NN cord-004751-4vl0cvyq 6 25 . . . cord-004751-4vl0cvyq 7 1 Two two CD cord-004751-4vl0cvyq 7 2 strains strain NNS cord-004751-4vl0cvyq 7 3 which which WDT cord-004751-4vl0cvyq 7 4 proved prove VBD cord-004751-4vl0cvyq 7 5 to to TO cord-004751-4vl0cvyq 7 6 be be VB cord-004751-4vl0cvyq 7 7 attenuated attenuate VBN cord-004751-4vl0cvyq 7 8 for for IN cord-004751-4vl0cvyq 7 9 volunteers volunteer NNS cord-004751-4vl0cvyq 7 10 did do VBD cord-004751-4vl0cvyq 7 11 not not RB cord-004751-4vl0cvyq 7 12 cause cause VB cord-004751-4vl0cvyq 7 13 appreciable appreciable JJ cord-004751-4vl0cvyq 7 14 damage damage NN cord-004751-4vl0cvyq 7 15 , , , cord-004751-4vl0cvyq 7 16 although although IN cord-004751-4vl0cvyq 7 17 they -PRON- PRP cord-004751-4vl0cvyq 7 18 replicated replicate VBD cord-004751-4vl0cvyq 7 19 to to IN cord-004751-4vl0cvyq 7 20 low low JJ cord-004751-4vl0cvyq 7 21 titre titre NN cord-004751-4vl0cvyq 7 22 in in IN cord-004751-4vl0cvyq 7 23 the the DT cord-004751-4vl0cvyq 7 24 epithelium epithelium NN cord-004751-4vl0cvyq 7 25 . . . cord-004751-4vl0cvyq 8 1 Similar similar JJ cord-004751-4vl0cvyq 8 2 results result NNS cord-004751-4vl0cvyq 8 3 were be VBD cord-004751-4vl0cvyq 8 4 obtained obtain VBN cord-004751-4vl0cvyq 8 5 with with IN cord-004751-4vl0cvyq 8 6 influenza influenza NN cord-004751-4vl0cvyq 8 7 A a DT cord-004751-4vl0cvyq 8 8 virus virus NN cord-004751-4vl0cvyq 8 9 attenuated attenuate VBN cord-004751-4vl0cvyq 8 10 by by IN cord-004751-4vl0cvyq 8 11 passage passage NN cord-004751-4vl0cvyq 8 12 in in IN cord-004751-4vl0cvyq 8 13 the the DT cord-004751-4vl0cvyq 8 14 presence presence NN cord-004751-4vl0cvyq 8 15 of of IN cord-004751-4vl0cvyq 8 16 horse horse NNP cord-004751-4vl0cvyq 8 17 sera sera NNP cord-004751-4vl0cvyq 8 18 . . . cord-004751-4vl0cvyq 9 1 The the DT cord-004751-4vl0cvyq 9 2 method method NN cord-004751-4vl0cvyq 9 3 may may MD cord-004751-4vl0cvyq 9 4 be be VB cord-004751-4vl0cvyq 9 5 of of IN cord-004751-4vl0cvyq 9 6 value value NN cord-004751-4vl0cvyq 9 7 for for IN cord-004751-4vl0cvyq 9 8 detecting detect VBG cord-004751-4vl0cvyq 9 9 virulent virulent JJ cord-004751-4vl0cvyq 9 10 live live JJ cord-004751-4vl0cvyq 9 11 influenza influenza NN cord-004751-4vl0cvyq 9 12 vaccine vaccine NN cord-004751-4vl0cvyq 9 13 candidates candidate NNS cord-004751-4vl0cvyq 9 14 without without IN cord-004751-4vl0cvyq 9 15 risking risk VBG cord-004751-4vl0cvyq 9 16 severe severe JJ cord-004751-4vl0cvyq 9 17 illness illness NN cord-004751-4vl0cvyq 9 18 in in IN cord-004751-4vl0cvyq 9 19 volunteers volunteer NNS cord-004751-4vl0cvyq 9 20 . . . cord-004751-4vl0cvyq 10 1 Attenuated attenuated JJ cord-004751-4vl0cvyq 10 2 influenza influenza NN cord-004751-4vl0cvyq 10 3 viruses virus NNS cord-004751-4vl0cvyq 10 4 have have VBP cord-004751-4vl0cvyq 10 5 been be VBN cord-004751-4vl0cvyq 10 6 produced produce VBN cord-004751-4vl0cvyq 10 7 recently recently RB cord-004751-4vl0cvyq 10 8 by by IN cord-004751-4vl0cvyq 10 9 genetic genetic JJ cord-004751-4vl0cvyq 10 10 recombination recombination NN cord-004751-4vl0cvyq 10 11 of of IN cord-004751-4vl0cvyq 10 12 avirulent avirulent JJ cord-004751-4vl0cvyq 10 13 laboratory laboratory NN cord-004751-4vl0cvyq 10 14 - - HYPH cord-004751-4vl0cvyq 10 15 adapted adapt VBN cord-004751-4vl0cvyq 10 16 strains strain NNS cord-004751-4vl0cvyq 10 17 and and CC cord-004751-4vl0cvyq 10 18 virulent virulent JJ cord-004751-4vl0cvyq 10 19 parents parent NNS cord-004751-4vl0cvyq 10 20 ( ( -LRB- cord-004751-4vl0cvyq 10 21 BEARE BEARE NNP cord-004751-4vl0cvyq 10 22 and and CC cord-004751-4vl0cvyq 10 23 HALL HALL NNP cord-004751-4vl0cvyq 10 24 , , , cord-004751-4vl0cvyq 10 25 1971 1971 CD cord-004751-4vl0cvyq 10 26 ; ; . cord-004751-4vl0cvyq 11 1 McCAHo~ McCAHo~ NNP cord-004751-4vl0cvyq 11 2 and and CC cord-004751-4vl0cvyq 11 3 SCHILD SCHILD NNP cord-004751-4vl0cvyq 11 4 , , , cord-004751-4vl0cvyq 11 5 1972 1972 CD cord-004751-4vl0cvyq 11 6 ) ) -RRB- cord-004751-4vl0cvyq 11 7 . . . cord-004751-4vl0cvyq 12 1 This this DT cord-004751-4vl0cvyq 12 2 method method NN cord-004751-4vl0cvyq 12 3 , , , cord-004751-4vl0cvyq 12 4 which which WDT cord-004751-4vl0cvyq 12 5 is be VBZ cord-004751-4vl0cvyq 12 6 the the DT cord-004751-4vl0cvyq 12 7 most most RBS cord-004751-4vl0cvyq 12 8 rapid rapid JJ cord-004751-4vl0cvyq 12 9 means mean NNS cord-004751-4vl0cvyq 12 10 of of IN cord-004751-4vl0cvyq 12 11 producing produce VBG cord-004751-4vl0cvyq 12 12 attenuated attenuated JJ cord-004751-4vl0cvyq 12 13 influenza influenza NN cord-004751-4vl0cvyq 12 14 strains strain NNS cord-004751-4vl0cvyq 12 15 to to IN cord-004751-4vl0cvyq 12 16 date date NN cord-004751-4vl0cvyq 12 17 , , , cord-004751-4vl0cvyq 12 18 results result NNS cord-004751-4vl0cvyq 12 19 in in IN cord-004751-4vl0cvyq 12 20 a a DT cord-004751-4vl0cvyq 12 21 spectrum spectrum NN cord-004751-4vl0cvyq 12 22 of of IN cord-004751-4vl0cvyq 12 23 both both CC cord-004751-4vl0cvyq 12 24 attenuated attenuated JJ cord-004751-4vl0cvyq 12 25 and and CC cord-004751-4vl0cvyq 12 26 virulent virulent JJ cord-004751-4vl0cvyq 12 27 clones clone NNS cord-004751-4vl0cvyq 12 28 as as IN cord-004751-4vl0cvyq 12 29 judged judge VBN cord-004751-4vl0cvyq 12 30 by by IN cord-004751-4vl0cvyq 12 31 their -PRON- PRP$ cord-004751-4vl0cvyq 12 32 effects effect NNS cord-004751-4vl0cvyq 12 33 in in IN cord-004751-4vl0cvyq 12 34 human human JJ cord-004751-4vl0cvyq 12 35 volunteers volunteer NNS cord-004751-4vl0cvyq 12 36 . . . cord-004751-4vl0cvyq 13 1 Unfortunately unfortunately RB cord-004751-4vl0cvyq 13 2 , , , cord-004751-4vl0cvyq 13 3 virulence virulence NN cord-004751-4vl0cvyq 13 4 can can MD cord-004751-4vl0cvyq 13 5 not not RB cord-004751-4vl0cvyq 13 6 be be VB cord-004751-4vl0cvyq 13 7 predicted predict VBN cord-004751-4vl0cvyq 13 8 by by IN cord-004751-4vl0cvyq 13 9 laboratory laboratory NN cord-004751-4vl0cvyq 13 10 tests test NNS cord-004751-4vl0cvyq 13 11 such such JJ cord-004751-4vl0cvyq 13 12 as as IN cord-004751-4vl0cvyq 13 13 yield yield NN cord-004751-4vl0cvyq 13 14 in in IN cord-004751-4vl0cvyq 13 15 eggs egg NNS cord-004751-4vl0cvyq 13 16 , , , cord-004751-4vl0cvyq 13 17 mouse mouse NN cord-004751-4vl0cvyq 13 18 virulence virulence NN cord-004751-4vl0cvyq 13 19 , , , cord-004751-4vl0cvyq 13 20 and and CC cord-004751-4vl0cvyq 13 21 growth growth NN cord-004751-4vl0cvyq 13 22 at at IN cord-004751-4vl0cvyq 13 23 high high JJ cord-004751-4vl0cvyq 13 24 temperatures temperature NNS cord-004751-4vl0cvyq 13 25 and and CC cord-004751-4vl0cvyq 13 26 volunteer volunteer NN cord-004751-4vl0cvyq 13 27 tests test NNS cord-004751-4vl0cvyq 13 28 are be VBP cord-004751-4vl0cvyq 13 29 slow slow JJ cord-004751-4vl0cvyq 13 30 and and CC cord-004751-4vl0cvyq 13 31 difficult difficult JJ cord-004751-4vl0cvyq 13 32 to to TO cord-004751-4vl0cvyq 13 33 quantitate quantitate VB cord-004751-4vl0cvyq 13 34 . . . cord-004751-4vl0cvyq 14 1 This this DT cord-004751-4vl0cvyq 14 2 method method NN cord-004751-4vl0cvyq 14 3 might may MD cord-004751-4vl0cvyq 14 4 occasionally occasionally RB cord-004751-4vl0cvyq 14 5 result result VB cord-004751-4vl0cvyq 14 6 in in IN cord-004751-4vl0cvyq 14 7 the the DT cord-004751-4vl0cvyq 14 8 production production NN cord-004751-4vl0cvyq 14 9 of of IN cord-004751-4vl0cvyq 14 10 new new JJ cord-004751-4vl0cvyq 14 11 phenotypes phenotype NNS cord-004751-4vl0cvyq 14 12 with with IN cord-004751-4vl0cvyq 14 13 characteristics characteristic NNS cord-004751-4vl0cvyq 14 14 not not RB cord-004751-4vl0cvyq 14 15 seen see VBN cord-004751-4vl0cvyq 14 16 in in IN cord-004751-4vl0cvyq 14 17 either either DT cord-004751-4vl0cvyq 14 18 parent parent NN cord-004751-4vl0cvyq 14 19 and and CC cord-004751-4vl0cvyq 14 20 a a DT cord-004751-4vl0cvyq 14 21 recombinant recombinant JJ cord-004751-4vl0cvyq 14 22 more more RBR cord-004751-4vl0cvyq 14 23 virulent virulent JJ cord-004751-4vl0cvyq 14 24 than than IN cord-004751-4vl0cvyq 14 25 the the DT cord-004751-4vl0cvyq 14 26 virulent virulent JJ cord-004751-4vl0cvyq 14 27 parent parent NN cord-004751-4vl0cvyq 14 28 strain strain NN cord-004751-4vl0cvyq 14 29 could could MD cord-004751-4vl0cvyq 14 30 be be VB cord-004751-4vl0cvyq 14 31 produced produce VBN cord-004751-4vl0cvyq 14 32 ( ( -LRB- cord-004751-4vl0cvyq 14 33 KILBOVR KILBOVR NNP cord-004751-4vl0cvyq 14 34 ~ ~ NFP cord-004751-4vl0cvyq 14 35 S S NNP cord-004751-4vl0cvyq 14 36 , , , cord-004751-4vl0cvyq 14 37 , , , cord-004751-4vl0cvyq 14 38 1969 1969 CD cord-004751-4vl0cvyq 14 39 ) ) -RRB- cord-004751-4vl0cvyq 14 40 . . . cord-004751-4vl0cvyq 15 1 For for IN cord-004751-4vl0cvyq 15 2 these these DT cord-004751-4vl0cvyq 15 3 reasons reason NNS cord-004751-4vl0cvyq 15 4 we -PRON- PRP cord-004751-4vl0cvyq 15 5 wished wish VBD cord-004751-4vl0cvyq 15 6 to to TO cord-004751-4vl0cvyq 15 7 find find VB cord-004751-4vl0cvyq 15 8 a a DT cord-004751-4vl0cvyq 15 9 new new JJ cord-004751-4vl0cvyq 15 10 in in IN cord-004751-4vl0cvyq 15 11 vitro vitro FW cord-004751-4vl0cvyq 15 12 marker marker NN cord-004751-4vl0cvyq 15 13 of of IN cord-004751-4vl0cvyq 15 14 influenza influenza NN cord-004751-4vl0cvyq 15 15 virus virus NN cord-004751-4vl0cvyq 15 16 virulence virulence NN cord-004751-4vl0cvyq 15 17 . . . cord-004751-4vl0cvyq 16 1 This this DT cord-004751-4vl0cvyq 16 2 paper paper NN cord-004751-4vl0cvyq 16 3 describes describe VBZ cord-004751-4vl0cvyq 16 4 a a DT cord-004751-4vl0cvyq 16 5 method method NN cord-004751-4vl0cvyq 16 6 using use VBG cord-004751-4vl0cvyq 16 7 the the DT cord-004751-4vl0cvyq 16 8 ciliated ciliated JJ cord-004751-4vl0cvyq 16 9 epithelium epithelium NN cord-004751-4vl0cvyq 16 10 of of IN cord-004751-4vl0cvyq 16 11 human human JJ cord-004751-4vl0cvyq 16 12 foetal foetal JJ cord-004751-4vl0cvyq 16 13 tracheal tracheal JJ cord-004751-4vl0cvyq 16 14 organ organ NN cord-004751-4vl0cvyq 16 15 culture culture NN cord-004751-4vl0cvyq 16 16 . . . cord-004751-4vl0cvyq 16 17 _SP cord-004751-4vl0cvyq 17 1 All all PDT cord-004751-4vl0cvyq 17 2 the the DT cord-004751-4vl0cvyq 17 3 viruses virus NNS cord-004751-4vl0cvyq 17 4 tested test VBN cord-004751-4vl0cvyq 17 5 were be VBD cord-004751-4vl0cvyq 17 6 provided provide VBN cord-004751-4vl0cvyq 17 7 by by IN cord-004751-4vl0cvyq 17 8 Dr. Dr. NNP cord-004751-4vl0cvyq 17 9 A. A. NNP cord-004751-4vl0cvyq 17 10 S. S. NNP cord-004751-4vl0cvyq 17 11 Beare Beare NNP cord-004751-4vl0cvyq 17 12 . . . cord-004751-4vl0cvyq 18 1 The the DT cord-004751-4vl0cvyq 18 2 parent parent NN cord-004751-4vl0cvyq 18 3 strains strain NNS cord-004751-4vl0cvyq 18 4 were be VBD cord-004751-4vl0cvyq 18 5 A a DT cord-004751-4vl0cvyq 18 6 / / SYM cord-004751-4vl0cvyq 18 7 PR pr NN cord-004751-4vl0cvyq 18 8 8/34 8/34 CD cord-004751-4vl0cvyq 18 9 ( ( -LRB- cord-004751-4vl0cvyq 18 10 HON0 HON0 NNP cord-004751-4vl0cvyq 18 11 ) ) -RRB- cord-004751-4vl0cvyq 18 12 of of IN cord-004751-4vl0cvyq 18 13 unknown unknown JJ cord-004751-4vl0cvyq 18 14 passage passage NN cord-004751-4vl0cvyq 18 15 history history NN cord-004751-4vl0cvyq 18 16 which which WDT cord-004751-4vl0cvyq 18 17 had have VBD cord-004751-4vl0cvyq 18 18 been be VBN cord-004751-4vl0cvyq 18 19 passed pass VBN cord-004751-4vl0cvyq 18 20 once once RB cord-004751-4vl0cvyq 18 21 in in IN cord-004751-4vl0cvyq 18 22 organ organ NN cord-004751-4vl0cvyq 18 23 cultures culture NNS cord-004751-4vl0cvyq 18 24 of of IN cord-004751-4vl0cvyq 18 25 human human JJ cord-004751-4vl0cvyq 18 26 embryo embryo NN cord-004751-4vl0cvyq 18 27 trachea trachea NN cord-004751-4vl0cvyq 18 28 and and CC cord-004751-4vl0cvyq 18 29 once once RB cord-004751-4vl0cvyq 18 30 in in IN cord-004751-4vl0cvyq 18 31 leukosis leukosis NN cord-004751-4vl0cvyq 18 32 free free JJ cord-004751-4vl0cvyq 18 33 eggs egg NNS cord-004751-4vl0cvyq 18 34 , , , cord-004751-4vl0cvyq 18 35 and and CC cord-004751-4vl0cvyq 18 36 a a DT cord-004751-4vl0cvyq 18 37 Hong Hong NNP cord-004751-4vl0cvyq 18 38 Kong Kong NNP cord-004751-4vl0cvyq 18 39 variant variant NN cord-004751-4vl0cvyq 18 40 known know VBN cord-004751-4vl0cvyq 18 41 as as IN cord-004751-4vl0cvyq 18 42 A A NNP cord-004751-4vl0cvyq 18 43 / / SYM cord-004751-4vl0cvyq 18 44 England/939/69 England/939/69 NNP cord-004751-4vl0cvyq 18 45 ( ( -LRB- cord-004751-4vl0cvyq 18 46 H H NNP cord-004751-4vl0cvyq 18 47 3 3 CD cord-004751-4vl0cvyq 18 48 N2)which n2)which NN cord-004751-4vl0cvyq 18 49 had have VBD cord-004751-4vl0cvyq 18 50 been be VBN cord-004751-4vl0cvyq 18 51 isolated isolate VBN cord-004751-4vl0cvyq 18 52 in in IN cord-004751-4vl0cvyq 18 53 leukosis leukosis NN cord-004751-4vl0cvyq 18 54 - - HYPH cord-004751-4vl0cvyq 18 55 free free JJ cord-004751-4vl0cvyq 18 56 eggs egg NNS cord-004751-4vl0cvyq 18 57 from from IN cord-004751-4vl0cvyq 18 58 an an DT cord-004751-4vl0cvyq 18 59 influenza influenza NN cord-004751-4vl0cvyq 18 60 patient patient NN cord-004751-4vl0cvyq 18 61 . . . cord-004751-4vl0cvyq 19 1 Two two CD cord-004751-4vl0cvyq 19 2 cloned clone VBN cord-004751-4vl0cvyq 19 3 recombinants recombinant NNS cord-004751-4vl0cvyq 19 4 of of IN cord-004751-4vl0cvyq 19 5 939 939 CD cord-004751-4vl0cvyq 19 6 • • NNS cord-004751-4vl0cvyq 20 1 PR PR NNP cord-004751-4vl0cvyq 20 2 8 8 CD cord-004751-4vl0cvyq 20 3 were be VBD cord-004751-4vl0cvyq 20 4 also also RB cord-004751-4vl0cvyq 20 5 provided provide VBN cord-004751-4vl0cvyq 20 6 for for IN cord-004751-4vl0cvyq 20 7 testing testing NN cord-004751-4vl0cvyq 20 8 . . . cord-004751-4vl0cvyq 21 1 These these DT cord-004751-4vl0cvyq 21 2 had have VBD cord-004751-4vl0cvyq 21 3 been be VBN cord-004751-4vl0cvyq 21 4 prepared prepare VBN cord-004751-4vl0cvyq 21 5 from from IN cord-004751-4vl0cvyq 21 6 the the DT cord-004751-4vl0cvyq 21 7 above above JJ cord-004751-4vl0cvyq 21 8 parents parent NNS cord-004751-4vl0cvyq 21 9 by by IN cord-004751-4vl0cvyq 21 10 Dr. Dr. NNP cord-004751-4vl0cvyq 21 11 D. D. NNP cord-004751-4vl0cvyq 21 12 McCahon McCahon NNP cord-004751-4vl0cvyq 21 13 and and CC cord-004751-4vl0cvyq 21 14 Dr. Dr. NNP cord-004751-4vl0cvyq 21 15 G. G. NNP cord-004751-4vl0cvyq 21 16 C. C. NNP cord-004751-4vl0cvyq 21 17 Schild Schild NNP cord-004751-4vl0cvyq 21 18 of of IN cord-004751-4vl0cvyq 21 19 the the DT cord-004751-4vl0cvyq 21 20 National National NNP cord-004751-4vl0cvyq 21 21 Institute Institute NNP cord-004751-4vl0cvyq 21 22 for for IN cord-004751-4vl0cvyq 21 23 Medical Medical NNP cord-004751-4vl0cvyq 21 24 Research Research NNP cord-004751-4vl0cvyq 21 25 by by IN cord-004751-4vl0cvyq 21 26 methods method NNS cord-004751-4vl0cvyq 21 27 previously previously RB cord-004751-4vl0cvyq 21 28 described describe VBN cord-004751-4vl0cvyq 21 29 ( ( -LRB- cord-004751-4vl0cvyq 21 30 MeCAI MeCAI NNP cord-004751-4vl0cvyq 21 31 ~ ~ NFP cord-004751-4vl0cvyq 21 32 OX OX NNP cord-004751-4vl0cvyq 21 33 and and CC cord-004751-4vl0cvyq 21 34 SCmLD SCmLD NNP cord-004751-4vl0cvyq 21 35 , , , cord-004751-4vl0cvyq 21 36 1972 1972 CD cord-004751-4vl0cvyq 21 37 ) ) -RRB- cord-004751-4vl0cvyq 21 38 . . . cord-004751-4vl0cvyq 22 1 Finally finally RB cord-004751-4vl0cvyq 22 2 , , , cord-004751-4vl0cvyq 22 3 two two CD cord-004751-4vl0cvyq 22 4 strains strain NNS cord-004751-4vl0cvyq 22 5 of of IN cord-004751-4vl0cvyq 22 6 A a NN cord-004751-4vl0cvyq 22 7 / / SYM cord-004751-4vl0cvyq 22 8 England/501/68 england/501/68 NN cord-004751-4vl0cvyq 22 9 ( ( -LRB- cord-004751-4vl0cvyq 22 10 H2N H2N NNP cord-004751-4vl0cvyq 22 11 2 2 CD cord-004751-4vl0cvyq 22 12 ) ) -RRB- cord-004751-4vl0cvyq 22 13 were be VBD cord-004751-4vl0cvyq 22 14 also also RB cord-004751-4vl0cvyq 22 15 tested test VBN cord-004751-4vl0cvyq 22 16 . . . cord-004751-4vl0cvyq 23 1 These these DT cord-004751-4vl0cvyq 23 2 were be VBD cord-004751-4vl0cvyq 23 3 an an DT cord-004751-4vl0cvyq 23 4 unmodified unmodified JJ cord-004751-4vl0cvyq 23 5 inhibitor inhibitor NN cord-004751-4vl0cvyq 23 6 sensitive sensitive JJ cord-004751-4vl0cvyq 23 7 strain strain NN cord-004751-4vl0cvyq 23 8 ( ( -LRB- cord-004751-4vl0cvyq 23 9 IS be VBZ cord-004751-4vl0cvyq 23 10 501 501 CD cord-004751-4vl0cvyq 23 11 ) ) -RRB- cord-004751-4vl0cvyq 23 12 and and CC cord-004751-4vl0cvyq 23 13 an an DT cord-004751-4vl0cvyq 23 14 inhibitor inhibitor NN cord-004751-4vl0cvyq 23 15 resistant resistant JJ cord-004751-4vl0cvyq 23 16 strain strain NN cord-004751-4vl0cvyq 23 17 ( ( -LRB- cord-004751-4vl0cvyq 23 18 IR IR NNP cord-004751-4vl0cvyq 23 19 501 501 CD cord-004751-4vl0cvyq 23 20 ) ) -RRB- cord-004751-4vl0cvyq 23 21 which which WDT cord-004751-4vl0cvyq 23 22 had have VBD cord-004751-4vl0cvyq 23 23 received receive VBN cord-004751-4vl0cvyq 23 24 several several JJ cord-004751-4vl0cvyq 23 25 passages passage NNS cord-004751-4vl0cvyq 23 26 at at IN cord-004751-4vl0cvyq 23 27 25 25 CD cord-004751-4vl0cvyq 24 1 ~ ~ NFP cord-004751-4vl0cvyq 24 2 C. C. NNP cord-004751-4vl0cvyq 24 3 The the DT cord-004751-4vl0cvyq 24 4 method method NN cord-004751-4vl0cvyq 24 5 is be VBZ cord-004751-4vl0cvyq 24 6 a a DT cord-004751-4vl0cvyq 24 7 modification modification NN cord-004751-4vl0cvyq 24 8 of of IN cord-004751-4vl0cvyq 24 9 those those DT cord-004751-4vl0cvyq 24 10 used use VBN cord-004751-4vl0cvyq 24 11 by by IN cord-004751-4vl0cvyq 24 12 others other NNS cord-004751-4vl0cvyq 24 13 ( ( -LRB- cord-004751-4vl0cvyq 25 1 CHEa•Y CHEa•Y NNP cord-004751-4vl0cvyq 25 2 and and CC cord-004751-4vl0cvyq 25 3 TAYLOI~-ROBInSOn TAYLOI~-ROBInSOn NNP cord-004751-4vl0cvyq 25 4 , , , cord-004751-4vl0cvyq 25 5 1970 1970 CD cord-004751-4vl0cvyq 25 6 ; ; : cord-004751-4vl0cvyq 25 7 H.~R H.~R NNP cord-004751-4vl0cvyq 25 8 ~ ~ NFP cord-004751-4vl0cvyq 25 9 ETT ETT NNP cord-004751-4vl0cvyq 25 10 and and CC cord-004751-4vl0cvyq 25 11 HOO]?E HOO]?E NNP cord-004751-4vl0cvyq 25 12 ~ ~ NFP cord-004751-4vl0cvyq 25 13 I i NN cord-004751-4vl0cvyq 25 14 1968 1968 CD cord-004751-4vl0cvyq 25 15 ; ; : cord-004751-4vl0cvyq 25 16 HOOR HOOR NNP cord-004751-4vl0cvyq 25 17 ~ ~ NFP cord-004751-4vl0cvyq 25 18 r r NN cord-004751-4vl0cvyq 25 19 and and CC cord-004751-4vl0cvyq 25 20 TYRI TYRI NNP cord-004751-4vl0cvyq 25 21 ~ ~ NFP cord-004751-4vl0cvyq 25 22 ELru ELru NNP cord-004751-4vl0cvyq 25 23 , , , cord-004751-4vl0cvyq 25 24 1969 1969 CD cord-004751-4vl0cvyq 25 25 ) ) -RRB- cord-004751-4vl0cvyq 25 26 . . . cord-004751-4vl0cvyq 26 1 Tracheau Tracheau NNP cord-004751-4vl0cvyq 26 2 from from IN cord-004751-4vl0cvyq 26 3 human human JJ cord-004751-4vl0cvyq 26 4 embryos embryo NNS cord-004751-4vl0cvyq 26 5 were be VBD cord-004751-4vl0cvyq 26 6 provided provide VBN cord-004751-4vl0cvyq 26 7 by by IN cord-004751-4vl0cvyq 26 8 the the DT cord-004751-4vl0cvyq 26 9 Royal Royal NNP cord-004751-4vl0cvyq 26 10 Marsden Marsden NNP cord-004751-4vl0cvyq 26 11 Hospital Hospital NNP cord-004751-4vl0cvyq 26 12 tissue tissue NN cord-004751-4vl0cvyq 26 13 bank bank NN cord-004751-4vl0cvyq 26 14 . . . cord-004751-4vl0cvyq 27 1 Foetal foetal JJ cord-004751-4vl0cvyq 27 2 age age NN cord-004751-4vl0cvyq 27 3 varied vary VBD cord-004751-4vl0cvyq 27 4 15 15 CD cord-004751-4vl0cvyq 27 5 to to TO cord-004751-4vl0cvyq 27 6 24 24 CD cord-004751-4vl0cvyq 27 7 weeks week NNS cord-004751-4vl0cvyq 27 8 . . . cord-004751-4vl0cvyq 28 1 After after IN cord-004751-4vl0cvyq 28 2 transportation transportation NN cord-004751-4vl0cvyq 28 3 on on IN cord-004751-4vl0cvyq 28 4 ice ice NN cord-004751-4vl0cvyq 28 5 in in IN cord-004751-4vl0cvyq 28 6 Parker Parker NNP cord-004751-4vl0cvyq 28 7 's 's POS cord-004751-4vl0cvyq 28 8 199 199 CD cord-004751-4vl0cvyq 28 9 medium medium NN cord-004751-4vl0cvyq 28 10 to to IN cord-004751-4vl0cvyq 28 11 the the DT cord-004751-4vl0cvyq 28 12 laboratory laboratory NN cord-004751-4vl0cvyq 28 13 , , , cord-004751-4vl0cvyq 28 14 the the DT cord-004751-4vl0cvyq 28 15 tracheas trachea NNS cord-004751-4vl0cvyq 28 16 were be VBD cord-004751-4vl0cvyq 28 17 dissected dissect VBN cord-004751-4vl0cvyq 28 18 free free JJ cord-004751-4vl0cvyq 28 19 of of IN cord-004751-4vl0cvyq 28 20 connective connective JJ cord-004751-4vl0cvyq 28 21 tissue tissue NN cord-004751-4vl0cvyq 28 22 . . . cord-004751-4vl0cvyq 29 1 Complete complete JJ cord-004751-4vl0cvyq 29 2 rings ring NNS cord-004751-4vl0cvyq 29 3 were be VBD cord-004751-4vl0cvyq 29 4 prepared prepare VBN cord-004751-4vl0cvyq 29 5 by by IN cord-004751-4vl0cvyq 29 6 cutting cut VBG cord-004751-4vl0cvyq 29 7 transversely transversely RB cord-004751-4vl0cvyq 29 8 between between IN cord-004751-4vl0cvyq 29 9 the the DT cord-004751-4vl0cvyq 29 10 tracheal tracheal JJ cord-004751-4vl0cvyq 29 11 cartilages cartilage NNS cord-004751-4vl0cvyq 29 12 in in IN cord-004751-4vl0cvyq 29 13 a a DT cord-004751-4vl0cvyq 29 14 Petri Petri NNP cord-004751-4vl0cvyq 29 15 dish dish NN cord-004751-4vl0cvyq 29 16 supported support VBN cord-004751-4vl0cvyq 29 17 on on IN cord-004751-4vl0cvyq 29 18 a a DT cord-004751-4vl0cvyq 29 19 plastic plastic JJ cord-004751-4vl0cvyq 29 20 platform platform NN cord-004751-4vl0cvyq 29 21 containing contain VBG cord-004751-4vl0cvyq 29 22 a a DT cord-004751-4vl0cvyq 29 23 light light JJ cord-004751-4vl0cvyq 29 24 source source NN cord-004751-4vl0cvyq 29 25 . . . cord-004751-4vl0cvyq 30 1 The the DT cord-004751-4vl0cvyq 30 2 rings ring NNS cord-004751-4vl0cvyq 30 3 ( ( -LRB- cord-004751-4vl0cvyq 30 4 8 8 CD cord-004751-4vl0cvyq 30 5 - - HYPH cord-004751-4vl0cvyq 30 6 -12 -12 NN cord-004751-4vl0cvyq 30 7 per per IN cord-004751-4vl0cvyq 30 8 embryo embryo NN cord-004751-4vl0cvyq 30 9 ) ) -RRB- cord-004751-4vl0cvyq 30 10 were be VBD cord-004751-4vl0cvyq 30 11 carefully carefully RB cord-004751-4vl0cvyq 30 12 transferred transfer VBN cord-004751-4vl0cvyq 30 13 to to IN cord-004751-4vl0cvyq 30 14 sterile sterile JJ cord-004751-4vl0cvyq 30 15 screw screw JJ cord-004751-4vl0cvyq 30 16 - - HYPH cord-004751-4vl0cvyq 30 17 top top NN cord-004751-4vl0cvyq 30 18 tubes tube NNS cord-004751-4vl0cvyq 30 19 ( ( -LRB- cord-004751-4vl0cvyq 30 20 Flow flow NN cord-004751-4vl0cvyq 30 21 Laboratories Laboratories NNPS cord-004751-4vl0cvyq 30 22 ) ) -RRB- cord-004751-4vl0cvyq 30 23 containing contain VBG cord-004751-4vl0cvyq 30 24 I -PRON- PRP cord-004751-4vl0cvyq 30 25 ml ml NNP cord-004751-4vl0cvyq 30 26 of of IN cord-004751-4vl0cvyq 30 27 L-15 L-15 NNP cord-004751-4vl0cvyq 30 28 medium medium NN cord-004751-4vl0cvyq 30 29 ( ( -LRB- cord-004751-4vl0cvyq 30 30 LEIBOWTZ LEIBOWTZ NNP cord-004751-4vl0cvyq 30 31 , , , cord-004751-4vl0cvyq 30 32 1963 1963 CD cord-004751-4vl0cvyq 30 33 ) ) -RRB- cord-004751-4vl0cvyq 30 34 to to TO cord-004751-4vl0cvyq 30 35 which which WDT cord-004751-4vl0cvyq 30 36 had have VBD cord-004751-4vl0cvyq 30 37 been be VBN cord-004751-4vl0cvyq 30 38 added add VBN cord-004751-4vl0cvyq 30 39 i i PRP cord-004751-4vl0cvyq 30 40 per per IN cord-004751-4vl0cvyq 30 41 cent cent NN cord-004751-4vl0cvyq 30 42 L l NN cord-004751-4vl0cvyq 30 43 - - HYPH cord-004751-4vl0cvyq 30 44 glutamine glutamine NN cord-004751-4vl0cvyq 30 45 ( ( -LRB- cord-004751-4vl0cvyq 30 46 final final JJ cord-004751-4vl0cvyq 30 47 concentration concentration NN cord-004751-4vl0cvyq 30 48 ) ) -RRB- cord-004751-4vl0cvyq 30 49 , , , cord-004751-4vl0cvyq 30 50 I00 I00 NNP cord-004751-4vl0cvyq 30 51 units unit NNS cord-004751-4vl0cvyq 30 52 of of IN cord-004751-4vl0cvyq 30 53 penicillin penicillin NN cord-004751-4vl0cvyq 30 54 , , , cord-004751-4vl0cvyq 30 55 and and CC cord-004751-4vl0cvyq 30 56 100~g 100~g CD cord-004751-4vl0cvyq 30 57 streptomycin streptomycin NNS cord-004751-4vl0cvyq 30 58 . . . cord-004751-4vl0cvyq 31 1 Ferrets ferret NNS cord-004751-4vl0cvyq 31 2 were be VBD cord-004751-4vl0cvyq 31 3 given give VBN cord-004751-4vl0cvyq 31 4 a a DT cord-004751-4vl0cvyq 31 5 lethal lethal JJ cord-004751-4vl0cvyq 31 6 dose dose NN cord-004751-4vl0cvyq 31 7 of of IN cord-004751-4vl0cvyq 31 8 sodium sodium NN cord-004751-4vl0cvyq 31 9 pentothal pentothal NN cord-004751-4vl0cvyq 31 10 . . . cord-004751-4vl0cvyq 32 1 The the DT cord-004751-4vl0cvyq 32 2 skin skin NN cord-004751-4vl0cvyq 32 3 was be VBD cord-004751-4vl0cvyq 32 4 dissected dissect VBN cord-004751-4vl0cvyq 32 5 free free JJ cord-004751-4vl0cvyq 32 6 over over IN cord-004751-4vl0cvyq 32 7 the the DT cord-004751-4vl0cvyq 32 8 abdomen abdomen NN cord-004751-4vl0cvyq 32 9 and and CC cord-004751-4vl0cvyq 32 10 pulled pull VBD cord-004751-4vl0cvyq 32 11 upwards upwards RB cord-004751-4vl0cvyq 32 12 and and CC cord-004751-4vl0cvyq 32 13 over over IN cord-004751-4vl0cvyq 32 14 the the DT cord-004751-4vl0cvyq 32 15 head head NN cord-004751-4vl0cvyq 32 16 to to TO cord-004751-4vl0cvyq 32 17 provide provide VB cord-004751-4vl0cvyq 32 18 a a DT cord-004751-4vl0cvyq 32 19 sterile sterile JJ cord-004751-4vl0cvyq 32 20 environment environment NN cord-004751-4vl0cvyq 32 21 over over IN cord-004751-4vl0cvyq 32 22 the the DT cord-004751-4vl0cvyq 32 23 trachea trachea NN cord-004751-4vl0cvyq 32 24 . . . cord-004751-4vl0cvyq 33 1 The the DT cord-004751-4vl0cvyq 33 2 trachea trachea NN cord-004751-4vl0cvyq 33 3 was be VBD cord-004751-4vl0cvyq 33 4 dissected dissect VBN cord-004751-4vl0cvyq 33 5 free free JJ cord-004751-4vl0cvyq 33 6 of of IN cord-004751-4vl0cvyq 33 7 connective connective JJ cord-004751-4vl0cvyq 33 8 tissue tissue NN cord-004751-4vl0cvyq 33 9 , , , cord-004751-4vl0cvyq 33 10 removed remove VBN cord-004751-4vl0cvyq 33 11 , , , cord-004751-4vl0cvyq 33 12 placed place VBN cord-004751-4vl0cvyq 33 13 in in IN cord-004751-4vl0cvyq 33 14 medium medium NN cord-004751-4vl0cvyq 33 15 , , , cord-004751-4vl0cvyq 33 16 and and CC cord-004751-4vl0cvyq 33 17 handled handle VBN cord-004751-4vl0cvyq 33 18 as as IN cord-004751-4vl0cvyq 33 19 above above RB cord-004751-4vl0cvyq 33 20 . . . cord-004751-4vl0cvyq 34 1 After after IN cord-004751-4vl0cvyq 34 2 positioning position VBG cord-004751-4vl0cvyq 34 3 on on IN cord-004751-4vl0cvyq 34 4 the the DT cord-004751-4vl0cvyq 34 5 side side NN cord-004751-4vl0cvyq 34 6 of of IN cord-004751-4vl0cvyq 34 7 the the DT cord-004751-4vl0cvyq 34 8 tube tube NN cord-004751-4vl0cvyq 34 9 opposite opposite IN cord-004751-4vl0cvyq 34 10 the the DT cord-004751-4vl0cvyq 34 11 medium medium NN cord-004751-4vl0cvyq 34 12 , , , cord-004751-4vl0cvyq 34 13 the the DT cord-004751-4vl0cvyq 34 14 percentage percentage NN cord-004751-4vl0cvyq 34 15 of of IN cord-004751-4vl0cvyq 34 16 each each DT cord-004751-4vl0cvyq 34 17 ring ring NN cord-004751-4vl0cvyq 34 18 beating beating NN cord-004751-4vl0cvyq 34 19 was be VBD cord-004751-4vl0cvyq 34 20 estimated estimate VBN cord-004751-4vl0cvyq 34 21 using use VBG cord-004751-4vl0cvyq 34 22 transmitted transmit VBN cord-004751-4vl0cvyq 34 23 light light NN cord-004751-4vl0cvyq 34 24 and and CC cord-004751-4vl0cvyq 34 25 the the DT cord-004751-4vl0cvyq 34 26 low low JJ cord-004751-4vl0cvyq 34 27 power power NN cord-004751-4vl0cvyq 34 28 objective objective NN cord-004751-4vl0cvyq 34 29 of of IN cord-004751-4vl0cvyq 34 30 an an DT cord-004751-4vl0cvyq 34 31 ordinary ordinary JJ cord-004751-4vl0cvyq 34 32 microscope microscope NN cord-004751-4vl0cvyq 34 33 . . . cord-004751-4vl0cvyq 35 1 Differences difference NNS cord-004751-4vl0cvyq 35 2 in in IN cord-004751-4vl0cvyq 35 3 the the DT cord-004751-4vl0cvyq 35 4 vigour vigour NN cord-004751-4vl0cvyq 35 5 and and CC cord-004751-4vl0cvyq 35 6 speed speed NN cord-004751-4vl0cvyq 35 7 with with IN cord-004751-4vl0cvyq 35 8 which which WDT cord-004751-4vl0cvyq 35 9 the the DT cord-004751-4vl0cvyq 35 10 cilia cilia NN cord-004751-4vl0cvyq 35 11 beat beat VBP cord-004751-4vl0cvyq 35 12 were be VBD cord-004751-4vl0cvyq 35 13 discernible discernible JJ cord-004751-4vl0cvyq 35 14 , , , cord-004751-4vl0cvyq 35 15 but but CC cord-004751-4vl0cvyq 35 16 these these DT cord-004751-4vl0cvyq 35 17 were be VBD cord-004751-4vl0cvyq 35 18 ignored ignore VBN cord-004751-4vl0cvyq 35 19 . . . cord-004751-4vl0cvyq 36 1 Readings reading NNS cord-004751-4vl0cvyq 36 2 were be VBD cord-004751-4vl0cvyq 36 3 recorded record VBN cord-004751-4vl0cvyq 36 4 by by IN cord-004751-4vl0cvyq 36 5 the the DT cord-004751-4vl0cvyq 36 6 same same JJ cord-004751-4vl0cvyq 36 7 observer observer NN cord-004751-4vl0cvyq 36 8 ( ( -LRB- cord-004751-4vl0cvyq 36 9 SRM SRM NNP cord-004751-4vl0cvyq 36 10 ) ) -RRB- cord-004751-4vl0cvyq 36 11 each each DT cord-004751-4vl0cvyq 36 12 day day NN cord-004751-4vl0cvyq 36 13 . . . cord-004751-4vl0cvyq 37 1 The the DT cord-004751-4vl0cvyq 37 2 ferret ferret NN cord-004751-4vl0cvyq 37 3 rings ring NNS cord-004751-4vl0cvyq 37 4 , , , cord-004751-4vl0cvyq 37 5 because because IN cord-004751-4vl0cvyq 37 6 of of IN cord-004751-4vl0cvyq 37 7 their -PRON- PRP$ cord-004751-4vl0cvyq 37 8 large large JJ cord-004751-4vl0cvyq 37 9 size size NN cord-004751-4vl0cvyq 37 10 , , , cord-004751-4vl0cvyq 37 11 were be VBD cord-004751-4vl0cvyq 37 12 read read VBN cord-004751-4vl0cvyq 37 13 with with IN cord-004751-4vl0cvyq 37 14 an an DT cord-004751-4vl0cvyq 37 15 inverted inverted JJ cord-004751-4vl0cvyq 37 16 microscope microscope NN cord-004751-4vl0cvyq 37 17 . . . cord-004751-4vl0cvyq 38 1 The the DT cord-004751-4vl0cvyq 38 2 tissue tissue NN cord-004751-4vl0cvyq 38 3 was be VBD cord-004751-4vl0cvyq 38 4 rolled roll VBN cord-004751-4vl0cvyq 38 5 for for IN cord-004751-4vl0cvyq 38 6 24 24 CD cord-004751-4vl0cvyq 38 7 - - HYPH cord-004751-4vl0cvyq 38 8 -48 -48 NNP cord-004751-4vl0cvyq 38 9 hours hour NNS cord-004751-4vl0cvyq 38 10 before before IN cord-004751-4vl0cvyq 38 11 inoculation inoculation NN cord-004751-4vl0cvyq 38 12 with with IN cord-004751-4vl0cvyq 38 13 virus virus NN cord-004751-4vl0cvyq 38 14 to to TO cord-004751-4vl0cvyq 38 15 remove remove VB cord-004751-4vl0cvyq 38 16 free free JJ cord-004751-4vl0cvyq 38 17 cells cell NNS cord-004751-4vl0cvyq 38 18 and and CC cord-004751-4vl0cvyq 38 19 mucus mucus NN cord-004751-4vl0cvyq 38 20 . . . cord-004751-4vl0cvyq 39 1 After after IN cord-004751-4vl0cvyq 39 2 an an DT cord-004751-4vl0cvyq 39 3 additional additional JJ cord-004751-4vl0cvyq 39 4 medium medium NN cord-004751-4vl0cvyq 39 5 change change NN cord-004751-4vl0cvyq 39 6 , , , cord-004751-4vl0cvyq 39 7 105EIDs0 105eids0 CD cord-004751-4vl0cvyq 39 8 of of IN cord-004751-4vl0cvyq 39 9 virus virus NN cord-004751-4vl0cvyq 39 10 in in IN cord-004751-4vl0cvyq 39 11 0.2 0.2 CD cord-004751-4vl0cvyq 39 12 ml ml NNS cord-004751-4vl0cvyq 39 13 was be VBD cord-004751-4vl0cvyq 39 14 introduced introduce VBN cord-004751-4vl0cvyq 39 15 into into IN cord-004751-4vl0cvyq 39 16 the the DT cord-004751-4vl0cvyq 39 17 tube tube NN cord-004751-4vl0cvyq 39 18 which which WDT cord-004751-4vl0cvyq 39 19 was be VBD cord-004751-4vl0cvyq 39 20 then then RB cord-004751-4vl0cvyq 39 21 rolled roll VBN cord-004751-4vl0cvyq 39 22 continuously continuously RB cord-004751-4vl0cvyq 39 23 at at IN cord-004751-4vl0cvyq 39 24 33 33 CD cord-004751-4vl0cvyq 39 25 ~ ~ NFP cord-004751-4vl0cvyq 39 26 C. C. NNP cord-004751-4vl0cvyq 39 27 The the DT cord-004751-4vl0cvyq 39 28 virus virus NN cord-004751-4vl0cvyq 39 29 was be VBD cord-004751-4vl0cvyq 39 30 allowed allow VBN cord-004751-4vl0cvyq 39 31 to to TO cord-004751-4vl0cvyq 39 32 adsorb adsorb VB cord-004751-4vl0cvyq 39 33 for for IN cord-004751-4vl0cvyq 39 34 2 2 CD cord-004751-4vl0cvyq 39 35 hours hour NNS cord-004751-4vl0cvyq 39 36 and and CC cord-004751-4vl0cvyq 39 37 then then RB cord-004751-4vl0cvyq 39 38 the the DT cord-004751-4vl0cvyq 39 39 tissue tissue NN cord-004751-4vl0cvyq 39 40 was be VBD cord-004751-4vl0cvyq 39 41 washed wash VBN cord-004751-4vl0cvyq 39 42 three three CD cord-004751-4vl0cvyq 39 43 times time NNS cord-004751-4vl0cvyq 39 44 with with IN cord-004751-4vl0cvyq 39 45 medium medium NN cord-004751-4vl0cvyq 39 46 . . . cord-004751-4vl0cvyq 40 1 At at IN cord-004751-4vl0cvyq 40 2 24 24 CD cord-004751-4vl0cvyq 40 3 hours hour NNS cord-004751-4vl0cvyq 40 4 , , , cord-004751-4vl0cvyq 40 5 and and CC cord-004751-4vl0cvyq 40 6 thereafter thereafter RB cord-004751-4vl0cvyq 40 7 every every DT cord-004751-4vl0cvyq 40 8 48 48 CD cord-004751-4vl0cvyq 40 9 hours hour NNS cord-004751-4vl0cvyq 40 10 , , , cord-004751-4vl0cvyq 40 11 the the DT cord-004751-4vl0cvyq 40 12 tubes tube NNS cord-004751-4vl0cvyq 40 13 were be VBD cord-004751-4vl0cvyq 40 14 harvested harvest VBN cord-004751-4vl0cvyq 40 15 and and CC cord-004751-4vl0cvyq 40 16 fresh fresh JJ cord-004751-4vl0cvyq 40 17 medium medium NN cord-004751-4vl0cvyq 40 18 added add VBD cord-004751-4vl0cvyq 40 19 . . . cord-004751-4vl0cvyq 41 1 The the DT cord-004751-4vl0cvyq 41 2 entire entire JJ cord-004751-4vl0cvyq 41 3 1 1 CD cord-004751-4vl0cvyq 41 4 ml ml NNS cord-004751-4vl0cvyq 41 5 of of IN cord-004751-4vl0cvyq 41 6 medium medium NN cord-004751-4vl0cvyq 41 7 from from IN cord-004751-4vl0cvyq 41 8 each each DT cord-004751-4vl0cvyq 41 9 tube tube NN cord-004751-4vl0cvyq 41 10 was be VBD cord-004751-4vl0cvyq 41 11 removed remove VBN cord-004751-4vl0cvyq 41 12 aseeptically aseeptically RB cord-004751-4vl0cvyq 41 13 every every DT cord-004751-4vl0cvyq 41 14 other other JJ cord-004751-4vl0cvyq 41 15 day day NN cord-004751-4vl0cvyq 41 16 for for IN cord-004751-4vl0cvyq 41 17 the the DT cord-004751-4vl0cvyq 41 18 first first JJ cord-004751-4vl0cvyq 41 19 two two CD cord-004751-4vl0cvyq 41 20 weeks week NNS cord-004751-4vl0cvyq 41 21 and and CC cord-004751-4vl0cvyq 41 22 mixed mix VBN cord-004751-4vl0cvyq 41 23 with with IN cord-004751-4vl0cvyq 41 24 an an DT cord-004751-4vl0cvyq 41 25 equal equal JJ cord-004751-4vl0cvyq 41 26 volume volume NN cord-004751-4vl0cvyq 41 27 of of IN cord-004751-4vl0cvyq 41 28 nutrient nutrient NN cord-004751-4vl0cvyq 41 29 broth broth NN cord-004751-4vl0cvyq 41 30 , , , cord-004751-4vl0cvyq 41 31 pooled pool VBN cord-004751-4vl0cvyq 41 32 , , , cord-004751-4vl0cvyq 41 33 and and CC cord-004751-4vl0cvyq 41 34 stored store VBN cord-004751-4vl0cvyq 41 35 at at IN cord-004751-4vl0cvyq 42 1 --70 --70 NNP cord-004751-4vl0cvyq 43 1 ~ ~ NFP cord-004751-4vl0cvyq 43 2 C. C. NNP cord-004751-4vl0cvyq 43 3 Serial serial JJ cord-004751-4vl0cvyq 43 4 10-fold 10-fold JJ cord-004751-4vl0cvyq 43 5 dilutions dilution NNS cord-004751-4vl0cvyq 43 6 of of IN cord-004751-4vl0cvyq 43 7 virus virus NN cord-004751-4vl0cvyq 43 8 were be VBD cord-004751-4vl0cvyq 43 9 injected inject VBN cord-004751-4vl0cvyq 43 10 into into IN cord-004751-4vl0cvyq 43 11 the the DT cord-004751-4vl0cvyq 43 12 allantoic allantoic NNP cord-004751-4vl0cvyq 43 13 cavity cavity NN cord-004751-4vl0cvyq 43 14 of of IN cord-004751-4vl0cvyq 43 15 groups group NNS cord-004751-4vl0cvyq 43 16 of of IN cord-004751-4vl0cvyq 43 17 three three CD cord-004751-4vl0cvyq 43 18 10-day 10-day CD cord-004751-4vl0cvyq 43 19 embryonated embryonate VBN cord-004751-4vl0cvyq 43 20 chicken chicken NN cord-004751-4vl0cvyq 43 21 eggs egg NNS cord-004751-4vl0cvyq 43 22 . . . cord-004751-4vl0cvyq 44 1 After after IN cord-004751-4vl0cvyq 44 2 incubation incubation NN cord-004751-4vl0cvyq 44 3 at at IN cord-004751-4vl0cvyq 44 4 33 33 CD cord-004751-4vl0cvyq 44 5 ~ ~ CD cord-004751-4vl0cvyq 44 6 C c NN cord-004751-4vl0cvyq 44 7 for for IN cord-004751-4vl0cvyq 44 8 48 48 CD cord-004751-4vl0cvyq 44 9 to to TO cord-004751-4vl0cvyq 44 10 72 72 CD cord-004751-4vl0cvyq 44 11 hours hour NNS cord-004751-4vl0cvyq 44 12 , , , cord-004751-4vl0cvyq 44 13 the the DT cord-004751-4vl0cvyq 44 14 allantoic allantoic NNP cord-004751-4vl0cvyq 44 15 fluid fluid NN cord-004751-4vl0cvyq 44 16 was be VBD cord-004751-4vl0cvyq 44 17 harvested harvest VBN cord-004751-4vl0cvyq 44 18 and and CC cord-004751-4vl0cvyq 44 19 tested test VBN cord-004751-4vl0cvyq 44 20 for for IN cord-004751-4vl0cvyq 44 21 haemagglutinin haemagglutinin NNP cord-004751-4vl0cvyq 44 22 ( ( -LRB- cord-004751-4vl0cvyq 44 23 HA HA NNP cord-004751-4vl0cvyq 44 24 ) ) -RRB- cord-004751-4vl0cvyq 44 25 with with IN cord-004751-4vl0cvyq 44 26 0.5 0.5 CD cord-004751-4vl0cvyq 44 27 per per IN cord-004751-4vl0cvyq 44 28 cent cent NN cord-004751-4vl0cvyq 44 29 chicken chicken NN cord-004751-4vl0cvyq 44 30 red red JJ cord-004751-4vl0cvyq 44 31 blood blood NN cord-004751-4vl0cvyq 44 32 cells cell NNS cord-004751-4vl0cvyq 44 33 ( ( -LRB- cord-004751-4vl0cvyq 44 34 RBC RBC NNP cord-004751-4vl0cvyq 44 35 ) ) -RRB- cord-004751-4vl0cvyq 44 36 . . . cord-004751-4vl0cvyq 45 1 Titres titre NNS cord-004751-4vl0cvyq 45 2 were be VBD cord-004751-4vl0cvyq 45 3 expressed express VBN cord-004751-4vl0cvyq 45 4 as as IN cord-004751-4vl0cvyq 45 5 50 50 CD cord-004751-4vl0cvyq 45 6 per per IN cord-004751-4vl0cvyq 45 7 cent cent NN cord-004751-4vl0cvyq 45 8 egg egg NN cord-004751-4vl0cvyq 45 9 infectious infectious JJ cord-004751-4vl0cvyq 45 10 doses dose NNS cord-004751-4vl0cvyq 45 11 per per IN cord-004751-4vl0cvyq 45 12 millilitre millilitre NN cord-004751-4vl0cvyq 45 13 ( ( -LRB- cord-004751-4vl0cvyq 45 14 EIDs0 EIDs0 NNP cord-004751-4vl0cvyq 45 15 / / SYM cord-004751-4vl0cvyq 45 16 ml ml NN cord-004751-4vl0cvyq 45 17 ) ) -RRB- cord-004751-4vl0cvyq 45 18 . . . cord-004751-4vl0cvyq 46 1 Volunteers volunteer NNS cord-004751-4vl0cvyq 46 2 were be VBD cord-004751-4vl0cvyq 46 3 studied study VBN cord-004751-4vl0cvyq 46 4 in in IN cord-004751-4vl0cvyq 46 5 isolation isolation NN cord-004751-4vl0cvyq 46 6 by by IN cord-004751-4vl0cvyq 46 7 standard standard JJ cord-004751-4vl0cvyq 46 8 methods method NNS cord-004751-4vl0cvyq 46 9 as as RB cord-004751-4vl0cvyq 46 10 already already RB cord-004751-4vl0cvyq 46 11 described describe VBN cord-004751-4vl0cvyq 46 12 ( ( -LRB- cord-004751-4vl0cvyq 46 13 BEARE BEARE NNP cord-004751-4vl0cvyq 46 14 and and CC cord-004751-4vl0cvyq 46 15 HALL HALL NNP cord-004751-4vl0cvyq 46 16 , , , cord-004751-4vl0cvyq 46 17 1971 1971 CD cord-004751-4vl0cvyq 46 18 ) ) -RRB- cord-004751-4vl0cvyq 46 19 . . . cord-004751-4vl0cvyq 47 1 The the DT cord-004751-4vl0cvyq 47 2 number number NN cord-004751-4vl0cvyq 47 3 of of IN cord-004751-4vl0cvyq 47 4 days day NNS cord-004751-4vl0cvyq 47 5 of of IN cord-004751-4vl0cvyq 47 6 symptoms symptom NNS cord-004751-4vl0cvyq 47 7 and and CC cord-004751-4vl0cvyq 47 8 signs sign NNS cord-004751-4vl0cvyq 47 9 above above IN cord-004751-4vl0cvyq 47 10 a a DT cord-004751-4vl0cvyq 47 11 baseline baseline NN cord-004751-4vl0cvyq 47 12 were be VBD cord-004751-4vl0cvyq 47 13 combined combine VBN cord-004751-4vl0cvyq 47 14 to to TO cord-004751-4vl0cvyq 47 15 provide provide VB cord-004751-4vl0cvyq 47 16 a a DT cord-004751-4vl0cvyq 47 17 symptom symptom NN cord-004751-4vl0cvyq 47 18 score score NN cord-004751-4vl0cvyq 47 19 . . . cord-004751-4vl0cvyq 48 1 The the DT cord-004751-4vl0cvyq 48 2 use use NN cord-004751-4vl0cvyq 48 3 of of IN cord-004751-4vl0cvyq 48 4 L-15 L-15 NNP cord-004751-4vl0cvyq 48 5 medium medium NN cord-004751-4vl0cvyq 48 6 and and CC cord-004751-4vl0cvyq 48 7 rolling roll VBG cord-004751-4vl0cvyq 48 8 the the DT cord-004751-4vl0cvyq 48 9 screw screw NN cord-004751-4vl0cvyq 48 10 - - HYPH cord-004751-4vl0cvyq 48 11 topped top VBN cord-004751-4vl0cvyq 48 12 tubes tube NNS cord-004751-4vl0cvyq 48 13 prolonged prolong VBD cord-004751-4vl0cvyq 48 14 the the DT cord-004751-4vl0cvyq 48 15 survival survival NN cord-004751-4vl0cvyq 48 16 of of IN cord-004751-4vl0cvyq 48 17 the the DT cord-004751-4vl0cvyq 48 18 ciliated ciliated JJ cord-004751-4vl0cvyq 48 19 epithelium epithelium NN cord-004751-4vl0cvyq 48 20 beyond beyond IN cord-004751-4vl0cvyq 48 21 that that DT cord-004751-4vl0cvyq 48 22 obtained obtain VBN cord-004751-4vl0cvyq 48 23 using use VBG cord-004751-4vl0cvyq 48 24 other other JJ cord-004751-4vl0cvyq 48 25 standard standard JJ cord-004751-4vl0cvyq 48 26 media medium NNS cord-004751-4vl0cvyq 48 27 , , , cord-004751-4vl0cvyq 48 28 and and CC cord-004751-4vl0cvyq 48 29 , , , cord-004751-4vl0cvyq 48 30 in in IN cord-004751-4vl0cvyq 48 31 the the DT cord-004751-4vl0cvyq 48 32 conditions condition NNS cord-004751-4vl0cvyq 48 33 finally finally RB cord-004751-4vl0cvyq 48 34 used use VBN cord-004751-4vl0cvyq 48 35 , , , cord-004751-4vl0cvyq 48 36 the the DT cord-004751-4vl0cvyq 48 37 human human JJ cord-004751-4vl0cvyq 48 38 embryo embryo NN cord-004751-4vl0cvyq 48 39 trachea trachea NN cord-004751-4vl0cvyq 48 40 regularly regularly RB cord-004751-4vl0cvyq 48 41 survived survive VBD cord-004751-4vl0cvyq 48 42 for for IN cord-004751-4vl0cvyq 48 43 periods period NNS cord-004751-4vl0cvyq 48 44 of of IN cord-004751-4vl0cvyq 48 45 30 30 CD cord-004751-4vl0cvyq 48 46 - - HYPH cord-004751-4vl0cvyq 48 47 -50 -50 NN cord-004751-4vl0cvyq 48 48 and and CC cord-004751-4vl0cvyq 48 49 occasionally occasionally RB cord-004751-4vl0cvyq 48 50 90 90 CD cord-004751-4vl0cvyq 48 51 days day NNS cord-004751-4vl0cvyq 48 52 . . . cord-004751-4vl0cvyq 49 1 The the DT cord-004751-4vl0cvyq 49 2 rings ring NNS cord-004751-4vl0cvyq 49 3 tend tend VBP cord-004751-4vl0cvyq 49 4 to to TO cord-004751-4vl0cvyq 49 5 adhere adhere VB cord-004751-4vl0cvyq 49 6 to to IN cord-004751-4vl0cvyq 49 7 one one CD cord-004751-4vl0cvyq 49 8 side side NN cord-004751-4vl0cvyq 49 9 of of IN cord-004751-4vl0cvyq 49 10 the the DT cord-004751-4vl0cvyq 49 11 tube tube NN cord-004751-4vl0cvyq 49 12 and and CC cord-004751-4vl0cvyq 49 13 remain remain VB cord-004751-4vl0cvyq 49 14 in in IN cord-004751-4vl0cvyq 49 15 this this DT cord-004751-4vl0cvyq 49 16 position position NN cord-004751-4vl0cvyq 49 17 if if IN cord-004751-4vl0cvyq 49 18 undisturbed undisturbed JJ cord-004751-4vl0cvyq 49 19 . . . cord-004751-4vl0cvyq 50 1 To to TO cord-004751-4vl0cvyq 50 2 prevent prevent VB cord-004751-4vl0cvyq 50 3 the the DT cord-004751-4vl0cvyq 50 4 accumulation accumulation NN cord-004751-4vl0cvyq 50 5 of of IN cord-004751-4vl0cvyq 50 6 debris debris NN cord-004751-4vl0cvyq 50 7 in in IN cord-004751-4vl0cvyq 50 8 the the DT cord-004751-4vl0cvyq 50 9 centre centre NN cord-004751-4vl0cvyq 50 10 of of IN cord-004751-4vl0cvyq 50 11 the the DT cord-004751-4vl0cvyq 50 12 x'ing x'ing NN cord-004751-4vl0cvyq 50 13 , , , cord-004751-4vl0cvyq 50 14 thus thus RB cord-004751-4vl0cvyq 50 15 obscuring obscure VBG cord-004751-4vl0cvyq 50 16 the the DT cord-004751-4vl0cvyq 50 17 cilia cilia NN cord-004751-4vl0cvyq 50 18 , , , cord-004751-4vl0cvyq 50 19 the the DT cord-004751-4vl0cvyq 50 20 tubes tube NNS cord-004751-4vl0cvyq 50 21 were be VBD cord-004751-4vl0cvyq 50 22 shaken shake VBN cord-004751-4vl0cvyq 50 23 gently gently RB cord-004751-4vl0cvyq 50 24 each each DT cord-004751-4vl0cvyq 50 25 day day NN cord-004751-4vl0cvyq 50 26 . . . cord-004751-4vl0cvyq 51 1 Occasionally occasionally RB cord-004751-4vl0cvyq 51 2 it -PRON- PRP cord-004751-4vl0cvyq 51 3 was be VBD cord-004751-4vl0cvyq 51 4 necessary necessary JJ cord-004751-4vl0cvyq 51 5 to to TO cord-004751-4vl0cvyq 51 6 dislodge dislodge VB cord-004751-4vl0cvyq 51 7 a a DT cord-004751-4vl0cvyq 51 8 ring ring NN cord-004751-4vl0cvyq 51 9 because because IN cord-004751-4vl0cvyq 51 10 flbroblasts flbroblast NNS cord-004751-4vl0cvyq 51 11 appeared appear VBD cord-004751-4vl0cvyq 51 12 at at IN cord-004751-4vl0cvyq 51 13 the the DT cord-004751-4vl0cvyq 51 14 point point NN cord-004751-4vl0cvyq 51 15 of of IN cord-004751-4vl0cvyq 51 16 attachment attachment NN cord-004751-4vl0cvyq 51 17 after after IN cord-004751-4vl0cvyq 51 18 12 12 CD cord-004751-4vl0cvyq 51 19 - - HYPH cord-004751-4vl0cvyq 51 20 -14 -14 NN cord-004751-4vl0cvyq 51 21 days day NNS cord-004751-4vl0cvyq 51 22 and and CC cord-004751-4vl0cvyq 51 23 obscured obscure VBD cord-004751-4vl0cvyq 51 24 the the DT cord-004751-4vl0cvyq 51 25 cilia cilia NN cord-004751-4vl0cvyq 51 26 . . . cord-004751-4vl0cvyq 52 1 Finally finally RB cord-004751-4vl0cvyq 52 2 , , , cord-004751-4vl0cvyq 52 3 after after IN cord-004751-4vl0cvyq 52 4 preparation preparation NN cord-004751-4vl0cvyq 52 5 of of IN cord-004751-4vl0cvyq 52 6 the the DT cord-004751-4vl0cvyq 52 7 rings ring NNS cord-004751-4vl0cvyq 52 8 , , , cord-004751-4vl0cvyq 52 9 there there EX cord-004751-4vl0cvyq 52 10 was be VBD cord-004751-4vl0cvyq 52 11 a a DT cord-004751-4vl0cvyq 52 12 definite definite JJ cord-004751-4vl0cvyq 52 13 improvement improvement NN cord-004751-4vl0cvyq 52 14 of of IN cord-004751-4vl0cvyq 52 15 the the DT cord-004751-4vl0cvyq 52 16 ciliary ciliary NN cord-004751-4vl0cvyq 52 17 activity activity NN cord-004751-4vl0cvyq 52 18 over over IN cord-004751-4vl0cvyq 52 19 the the DT cord-004751-4vl0cvyq 52 20 first first JJ cord-004751-4vl0cvyq 52 21 24 24 CD cord-004751-4vl0cvyq 52 22 - - SYM cord-004751-4vl0cvyq 52 23 -72 -72 CD cord-004751-4vl0cvyq 52 24 hours hour NNS cord-004751-4vl0cvyq 52 25 . . . cord-004751-4vl0cvyq 53 1 Therefore therefore RB cord-004751-4vl0cvyq 53 2 the the DT cord-004751-4vl0cvyq 53 3 reading reading NN cord-004751-4vl0cvyq 53 4 on on IN cord-004751-4vl0cvyq 53 5 the the DT cord-004751-4vl0cvyq 53 6 day day NN cord-004751-4vl0cvyq 53 7 of of IN cord-004751-4vl0cvyq 53 8 inoculation inoculation NN cord-004751-4vl0cvyq 53 9 was be VBD cord-004751-4vl0cvyq 53 10 used use VBN cord-004751-4vl0cvyq 53 11 as as IN cord-004751-4vl0cvyq 53 12 a a DT cord-004751-4vl0cvyq 53 13 baseline baseline NN cord-004751-4vl0cvyq 53 14 . . . cord-004751-4vl0cvyq 54 1 It -PRON- PRP cord-004751-4vl0cvyq 54 2 was be VBD cord-004751-4vl0cvyq 54 3 frequently frequently RB cord-004751-4vl0cvyq 54 4 impossible impossible JJ cord-004751-4vl0cvyq 54 5 to to TO cord-004751-4vl0cvyq 54 6 test test VB cord-004751-4vl0cvyq 54 7 all all PDT cord-004751-4vl0cvyq 54 8 the the DT cord-004751-4vl0cvyq 54 9 viruses virus NNS cord-004751-4vl0cvyq 54 10 in in IN cord-004751-4vl0cvyq 54 11 the the DT cord-004751-4vl0cvyq 54 12 trachea trachea NN cord-004751-4vl0cvyq 54 13 from from IN cord-004751-4vl0cvyq 54 14 the the DT cord-004751-4vl0cvyq 54 15 same same JJ cord-004751-4vl0cvyq 54 16 embryo embryo NN cord-004751-4vl0cvyq 54 17 on on IN cord-004751-4vl0cvyq 54 18 the the DT cord-004751-4vl0cvyq 54 19 same same JJ cord-004751-4vl0cvyq 54 20 day day NN cord-004751-4vl0cvyq 54 21 , , , cord-004751-4vl0cvyq 54 22 and and CC cord-004751-4vl0cvyq 54 23 for for IN cord-004751-4vl0cvyq 54 24 this this DT cord-004751-4vl0cvyq 54 25 report report NN cord-004751-4vl0cvyq 54 26 the the DT cord-004751-4vl0cvyq 54 27 data datum NNS cord-004751-4vl0cvyq 54 28 have have VBP cord-004751-4vl0cvyq 54 29 been be VBN cord-004751-4vl0cvyq 54 30 pooled pool VBN cord-004751-4vl0cvyq 54 31 and and CC cord-004751-4vl0cvyq 54 32 are be VBP cord-004751-4vl0cvyq 54 33 based base VBN cord-004751-4vl0cvyq 54 34 on on IN cord-004751-4vl0cvyq 54 35 the the DT cord-004751-4vl0cvyq 54 36 observation observation NN cord-004751-4vl0cvyq 54 37 of of IN cord-004751-4vl0cvyq 54 38 15 15 CD cord-004751-4vl0cvyq 54 39 - - HYPH cord-004751-4vl0cvyq 54 40 -20 -20 NN cord-004751-4vl0cvyq 54 41 rings ring NNS cord-004751-4vl0cvyq 54 42 infected infect VBN cord-004751-4vl0cvyq 54 43 with with IN cord-004751-4vl0cvyq 54 44 each each DT cord-004751-4vl0cvyq 54 45 virus virus NN cord-004751-4vl0cvyq 54 46 . . . cord-004751-4vl0cvyq 55 1 Several several JJ cord-004751-4vl0cvyq 55 2 uninoeulated uninoeulate VBN cord-004751-4vl0cvyq 55 3 cultures culture NNS cord-004751-4vl0cvyq 55 4 were be VBD cord-004751-4vl0cvyq 55 5 included include VBN cord-004751-4vl0cvyq 55 6 in in IN cord-004751-4vl0cvyq 55 7 each each DT cord-004751-4vl0cvyq 55 8 test test NN cord-004751-4vl0cvyq 55 9 . . . cord-004751-4vl0cvyq 56 1 As as IN cord-004751-4vl0cvyq 56 2 shown show VBN cord-004751-4vl0cvyq 56 3 in in IN cord-004751-4vl0cvyq 56 4 Figure figure NN cord-004751-4vl0cvyq 56 5 1 1 CD cord-004751-4vl0cvyq 56 6 , , , cord-004751-4vl0cvyq 56 7 the the DT cord-004751-4vl0cvyq 56 8 ciliary ciliary NN cord-004751-4vl0cvyq 56 9 activity activity NN cord-004751-4vl0cvyq 56 10 in in IN cord-004751-4vl0cvyq 56 11 cultures culture NNS cord-004751-4vl0cvyq 56 12 infected infect VBN cord-004751-4vl0cvyq 56 13 with with IN cord-004751-4vl0cvyq 56 14 this this DT cord-004751-4vl0cvyq 56 15 strain strain NN cord-004751-4vl0cvyq 56 16 was be VBD cord-004751-4vl0cvyq 56 17 the the DT cord-004751-4vl0cvyq 56 18 same same JJ cord-004751-4vl0cvyq 56 19 as as IN cord-004751-4vl0cvyq 56 20 that that DT cord-004751-4vl0cvyq 56 21 in in IN cord-004751-4vl0cvyq 56 22 uninoculated uninoculated JJ cord-004751-4vl0cvyq 56 23 tubes tube NNS cord-004751-4vl0cvyq 56 24 and and CC cord-004751-4vl0cvyq 56 25 in in IN cord-004751-4vl0cvyq 56 26 fact fact NN cord-004751-4vl0cvyq 56 27 the the DT cord-004751-4vl0cvyq 56 28 cilia cilia NN cord-004751-4vl0cvyq 56 29 in in IN cord-004751-4vl0cvyq 56 30 some some DT cord-004751-4vl0cvyq 56 31 inoculated inoculate VBN cord-004751-4vl0cvyq 56 32 tubes tube NNS cord-004751-4vl0cvyq 56 33 were be VBD cord-004751-4vl0cvyq 56 34 more more RBR cord-004751-4vl0cvyq 56 35 active active JJ cord-004751-4vl0cvyq 56 36 than than IN cord-004751-4vl0cvyq 56 37 in in IN cord-004751-4vl0cvyq 56 38 controls control NNS cord-004751-4vl0cvyq 56 39 . . . cord-004751-4vl0cvyq 57 1 The the DT cord-004751-4vl0cvyq 57 2 virus virus NN cord-004751-4vl0cvyq 57 3 grew grow VBD cord-004751-4vl0cvyq 57 4 to to IN cord-004751-4vl0cvyq 57 5 low low JJ cord-004751-4vl0cvyq 57 6 titre titre NN cord-004751-4vl0cvyq 57 7 , , , cord-004751-4vl0cvyq 57 8 as as IN cord-004751-4vl0cvyq 57 9 shown show VBN cord-004751-4vl0cvyq 57 10 in in IN cord-004751-4vl0cvyq 57 11 Figure figure NN cord-004751-4vl0cvyq 57 12 2 2 CD cord-004751-4vl0cvyq 57 13 . . . cord-004751-4vl0cvyq 58 1 3.1.2 3.1.2 LS cord-004751-4vl0cvyq 58 2 . . . cord-004751-4vl0cvyq 59 1 Virus Virus NNP cord-004751-4vl0cvyq 59 2 Strain Strain NNP cord-004751-4vl0cvyq 60 1 A a LS cord-004751-4vl0cvyq 60 2 / / SYM cord-004751-4vl0cvyq 60 3 Eng.~939~69 Eng.~939~69 NNP cord-004751-4vl0cvyq 61 1 ( ( -LRB- cord-004751-4vl0cvyq 61 2 H3N2 H3N2 NNP cord-004751-4vl0cvyq 61 3 ) ) -RRB- cord-004751-4vl0cvyq 62 1 This this DT cord-004751-4vl0cvyq 62 2 strain strain NN cord-004751-4vl0cvyq 62 3 , , , cord-004751-4vl0cvyq 62 4 by by IN cord-004751-4vl0cvyq 62 5 contrast contrast NN cord-004751-4vl0cvyq 62 6 , , , cord-004751-4vl0cvyq 62 7 regularly regularly RB cord-004751-4vl0cvyq 62 8 destroyed destroy VBD cord-004751-4vl0cvyq 62 9 ciliated ciliated JJ cord-004751-4vl0cvyq 62 10 epithelium epithelium NN cord-004751-4vl0cvyq 62 11 . . . cord-004751-4vl0cvyq 63 1 The the DT cord-004751-4vl0cvyq 63 2 earliest early JJS cord-004751-4vl0cvyq 63 3 effects effect NNS cord-004751-4vl0cvyq 63 4 , , , cord-004751-4vl0cvyq 63 5 noticeable noticeable JJ cord-004751-4vl0cvyq 63 6 by by IN cord-004751-4vl0cvyq 63 7 the the DT cord-004751-4vl0cvyq 63 8 third third JJ cord-004751-4vl0cvyq 63 9 day day NN cord-004751-4vl0cvyq 63 10 after after IN cord-004751-4vl0cvyq 63 11 inoculation inoculation NN cord-004751-4vl0cvyq 63 12 , , , cord-004751-4vl0cvyq 63 13 were be VBD cord-004751-4vl0cvyq 63 14 the the DT cord-004751-4vl0cvyq 63 15 appearance appearance NN cord-004751-4vl0cvyq 63 16 of of IN cord-004751-4vl0cvyq 63 17 mucus mucus NN cord-004751-4vl0cvyq 63 18 and and CC cord-004751-4vl0cvyq 63 19 many many JJ cord-004751-4vl0cvyq 63 20 desquamated desquamate VBN cord-004751-4vl0cvyq 63 21 cells cell NNS cord-004751-4vl0cvyq 63 22 within within IN cord-004751-4vl0cvyq 63 23 the the DT cord-004751-4vl0cvyq 63 24 ring ring NN cord-004751-4vl0cvyq 63 25 . . . cord-004751-4vl0cvyq 64 1 The the DT cord-004751-4vl0cvyq 64 2 cilia cilium NNS cord-004751-4vl0cvyq 64 3 of of IN cord-004751-4vl0cvyq 64 4 some some DT cord-004751-4vl0cvyq 64 5 of of IN cord-004751-4vl0cvyq 64 6 these these DT cord-004751-4vl0cvyq 64 7 shed shed VBN cord-004751-4vl0cvyq 64 8 cells cell NNS cord-004751-4vl0cvyq 64 9 continued continue VBD cord-004751-4vl0cvyq 64 10 to to TO cord-004751-4vl0cvyq 64 11 beat beat VB cord-004751-4vl0cvyq 64 12 for for IN cord-004751-4vl0cvyq 64 13 a a DT cord-004751-4vl0cvyq 64 14 few few JJ cord-004751-4vl0cvyq 64 15 hours hour NNS cord-004751-4vl0cvyq 64 16 . . . cord-004751-4vl0cvyq 65 1 At at IN cord-004751-4vl0cvyq 65 2 this this DT cord-004751-4vl0cvyq 65 3 time time NN cord-004751-4vl0cvyq 65 4 the the DT cord-004751-4vl0cvyq 65 5 ciliated ciliated JJ cord-004751-4vl0cvyq 65 6 epithelium epithelium NN cord-004751-4vl0cvyq 65 7 looked look VBD cord-004751-4vl0cvyq 65 8 intact intact JJ cord-004751-4vl0cvyq 65 9 , , , cord-004751-4vl0cvyq 65 10 but but CC cord-004751-4vl0cvyq 65 11 by by IN cord-004751-4vl0cvyq 65 12 4 4 CD cord-004751-4vl0cvyq 65 13 - - HYPH cord-004751-4vl0cvyq 65 14 -6 -6 JJ cord-004751-4vl0cvyq 65 15 days day NNS cord-004751-4vl0cvyq 65 16 it -PRON- PRP cord-004751-4vl0cvyq 65 17 was be VBD cord-004751-4vl0cvyq 65 18 markedly markedly RB cord-004751-4vl0cvyq 65 19 damaged damage VBN cord-004751-4vl0cvyq 65 20 and and CC cord-004751-4vl0cvyq 65 21 by by IN cord-004751-4vl0cvyq 65 22 10 10 CD cord-004751-4vl0cvyq 65 23 days day NNS cord-004751-4vl0cvyq 65 24 ciliary ciliary NN cord-004751-4vl0cvyq 65 25 activity activity NN cord-004751-4vl0cvyq 65 26 had have VBD cord-004751-4vl0cvyq 65 27 ceased cease VBN cord-004751-4vl0cvyq 65 28 . . . cord-004751-4vl0cvyq 66 1 Histological histological JJ cord-004751-4vl0cvyq 66 2 sections section NNS cord-004751-4vl0cvyq 66 3 showed show VBD cord-004751-4vl0cvyq 66 4 that that IN cord-004751-4vl0cvyq 66 5 the the DT cord-004751-4vl0cvyq 66 6 epithelium epithelium NN cord-004751-4vl0cvyq 66 7 was be VBD cord-004751-4vl0cvyq 66 8 denuded denude VBN cord-004751-4vl0cvyq 66 9 of of IN cord-004751-4vl0cvyq 66 10 ciliated ciliated JJ cord-004751-4vl0cvyq 66 11 cells cell NNS cord-004751-4vl0cvyq 66 12 . . . cord-004751-4vl0cvyq 67 1 In in IN cord-004751-4vl0cvyq 67 2 a a DT cord-004751-4vl0cvyq 67 3 few few JJ cord-004751-4vl0cvyq 67 4 tracheas trachea NNS cord-004751-4vl0cvyq 67 5 the the DT cord-004751-4vl0cvyq 67 6 process process NN cord-004751-4vl0cvyq 67 7 was be VBD cord-004751-4vl0cvyq 67 8 delayed delay VBN cord-004751-4vl0cvyq 67 9 by by IN cord-004751-4vl0cvyq 67 10 two two CD cord-004751-4vl0cvyq 67 11 or or CC cord-004751-4vl0cvyq 67 12 three three CD cord-004751-4vl0cvyq 67 13 days day NNS cord-004751-4vl0cvyq 67 14 . . . cord-004751-4vl0cvyq 68 1 The the DT cord-004751-4vl0cvyq 68 2 growth growth NN cord-004751-4vl0cvyq 68 3 of of IN cord-004751-4vl0cvyq 68 4 virus virus NN cord-004751-4vl0cvyq 68 5 preceded precede VBD cord-004751-4vl0cvyq 68 6 the the DT cord-004751-4vl0cvyq 68 7 destruction destruction NN cord-004751-4vl0cvyq 68 8 of of IN cord-004751-4vl0cvyq 68 9 the the DT cord-004751-4vl0cvyq 68 10 ciliated ciliated JJ cord-004751-4vl0cvyq 68 11 epithelium epithelium NN cord-004751-4vl0cvyq 68 12 and and CC cord-004751-4vl0cvyq 68 13 the the DT cord-004751-4vl0cvyq 68 14 titre titre NN cord-004751-4vl0cvyq 68 15 was be VBD cord-004751-4vl0cvyq 68 16 the the DT cord-004751-4vl0cvyq 68 17 highest high JJS cord-004751-4vl0cvyq 68 18 of of IN cord-004751-4vl0cvyq 68 19 any any DT cord-004751-4vl0cvyq 68 20 virus virus NN cord-004751-4vl0cvyq 68 21 tested test VBN cord-004751-4vl0cvyq 68 22 ( ( -LRB- cord-004751-4vl0cvyq 68 23 Fig Fig NNP cord-004751-4vl0cvyq 68 24 . . NNP cord-004751-4vl0cvyq 68 25 2 2 CD cord-004751-4vl0cvyq 68 26 ) ) -RRB- cord-004751-4vl0cvyq 68 27 . . . cord-004751-4vl0cvyq 69 1 The the DT cord-004751-4vl0cvyq 69 2 growth growth NN cord-004751-4vl0cvyq 69 3 of of IN cord-004751-4vl0cvyq 69 4 virus virus NN cord-004751-4vl0cvyq 69 5 continued continue VBD cord-004751-4vl0cvyq 69 6 at at IN cord-004751-4vl0cvyq 69 7 a a DT cord-004751-4vl0cvyq 69 8 low low JJ cord-004751-4vl0cvyq 69 9 level level NN cord-004751-4vl0cvyq 69 10 after after IN cord-004751-4vl0cvyq 69 11 the the DT cord-004751-4vl0cvyq 69 12 cilia cilia NN cord-004751-4vl0cvyq 69 13 were be VBD cord-004751-4vl0cvyq 69 14 destroyed destroy VBN cord-004751-4vl0cvyq 69 15 and and CC cord-004751-4vl0cvyq 69 16 was be VBD cord-004751-4vl0cvyq 69 17 detected detect VBN cord-004751-4vl0cvyq 69 18 at at IN cord-004751-4vl0cvyq 69 19 titres titre NNS cord-004751-4vl0cvyq 69 20 between between IN cord-004751-4vl0cvyq 69 21 102 102 CD cord-004751-4vl0cvyq 69 22 and and CC cord-004751-4vl0cvyq 69 23 103 103 CD cord-004751-4vl0cvyq 69 24 EIDs0 EIDs0 NNP cord-004751-4vl0cvyq 69 25 / / SYM cord-004751-4vl0cvyq 69 26 ml ml NN cord-004751-4vl0cvyq 69 27 for for IN cord-004751-4vl0cvyq 69 28 up up IN cord-004751-4vl0cvyq 69 29 to to TO cord-004751-4vl0cvyq 69 30 35 35 CD cord-004751-4vl0cvyq 69 31 days day NNS cord-004751-4vl0cvyq 69 32 . . . cord-004751-4vl0cvyq 70 1 This this DT cord-004751-4vl0cvyq 70 2 virus virus NN cord-004751-4vl0cvyq 70 3 behaved behave VBD cord-004751-4vl0cvyq 70 4 similarly similarly RB cord-004751-4vl0cvyq 70 5 to to IN cord-004751-4vl0cvyq 70 6 the the DT cord-004751-4vl0cvyq 70 7 A A NNP cord-004751-4vl0cvyq 70 8 / / SYM cord-004751-4vl0cvyq 70 9 PR PR NNP cord-004751-4vl0cvyq 70 10 8 8 CD cord-004751-4vl0cvyq 70 11 parent parent NN cord-004751-4vl0cvyq 70 12 and and CC cord-004751-4vl0cvyq 70 13 caused cause VBD cord-004751-4vl0cvyq 70 14 very very RB cord-004751-4vl0cvyq 70 15 little little JJ cord-004751-4vl0cvyq 70 16 ciliary ciliary NN cord-004751-4vl0cvyq 70 17 damage damage NN cord-004751-4vl0cvyq 70 18 . . . cord-004751-4vl0cvyq 71 1 However however RB cord-004751-4vl0cvyq 71 2 , , , cord-004751-4vl0cvyq 71 3 it -PRON- PRP cord-004751-4vl0cvyq 71 4 grew grow VBD cord-004751-4vl0cvyq 71 5 to to IN cord-004751-4vl0cvyq 71 6 slightly slightly RB cord-004751-4vl0cvyq 71 7 higher high JJR cord-004751-4vl0cvyq 71 8 titres titre NNS cord-004751-4vl0cvyq 71 9 in in IN cord-004751-4vl0cvyq 71 10 the the DT cord-004751-4vl0cvyq 71 11 ciliated ciliated JJ cord-004751-4vl0cvyq 71 12 epithelium epithelium NN cord-004751-4vl0cvyq 71 13 than than IN cord-004751-4vl0cvyq 71 14 did do VBD cord-004751-4vl0cvyq 71 15 the the DT cord-004751-4vl0cvyq 71 16 parent parent NN cord-004751-4vl0cvyq 71 17 . . . cord-004751-4vl0cvyq 72 1 3.1.4 3.1.4 NNP cord-004751-4vl0cvyq 72 2 . . . cord-004751-4vl0cvyq 73 1 Clone clone NN cord-004751-4vl0cvyq 73 2 6 6 CD cord-004751-4vl0cvyq 73 3 ( ( -LRB- cord-004751-4vl0cvyq 73 4 PLY8 PLY8 NNP cord-004751-4vl0cvyq 73 5 x x SYM cord-004751-4vl0cvyq 73 6 939 939 CD cord-004751-4vl0cvyq 73 7 ) ) -RRB- cord-004751-4vl0cvyq 74 1 This this DT cord-004751-4vl0cvyq 74 2 recombinant recombinant NN cord-004751-4vl0cvyq 74 3 was be VBD cord-004751-4vl0cvyq 74 4 of of IN cord-004751-4vl0cvyq 74 5 intermediate intermediate JJ cord-004751-4vl0cvyq 74 6 pathogenicity pathogenicity NN cord-004751-4vl0cvyq 74 7 for for IN cord-004751-4vl0cvyq 74 8 cilia cilia NN cord-004751-4vl0cvyq 74 9 , , , cord-004751-4vl0cvyq 74 10 but but CC cord-004751-4vl0cvyq 74 11 more more RBR cord-004751-4vl0cvyq 74 12 closely closely RB cord-004751-4vl0cvyq 74 13 resembled resemble VBN cord-004751-4vl0cvyq 74 14 the the DT cord-004751-4vl0cvyq 74 15 A A NNP cord-004751-4vl0cvyq 74 16 / / SYM cord-004751-4vl0cvyq 74 17 Eng Eng NNP cord-004751-4vl0cvyq 74 18 . . NNP cord-004751-4vl0cvyq 74 19 parent parent NN cord-004751-4vl0cvyq 74 20 . . . cord-004751-4vl0cvyq 75 1 In in IN cord-004751-4vl0cvyq 75 2 other other JJ cord-004751-4vl0cvyq 75 3 words word NNS cord-004751-4vl0cvyq 75 4 some some DT cord-004751-4vl0cvyq 75 5 rings ring NNS cord-004751-4vl0cvyq 75 6 would would MD cord-004751-4vl0cvyq 75 7 resist resist VB cord-004751-4vl0cvyq 75 8 growth growth NN cord-004751-4vl0cvyq 75 9 and and CC cord-004751-4vl0cvyq 75 10 25 25 CD cord-004751-4vl0cvyq 75 11 * * NFP cord-004751-4vl0cvyq 75 12 destruction destruction NN cord-004751-4vl0cvyq 75 13 for for IN cord-004751-4vl0cvyq 75 14 a a DT cord-004751-4vl0cvyq 75 15 few few JJ cord-004751-4vl0cvyq 75 16 days day NNS cord-004751-4vl0cvyq 75 17 longer long RBR cord-004751-4vl0cvyq 75 18 than than IN cord-004751-4vl0cvyq 75 19 average average JJ cord-004751-4vl0cvyq 75 20 , , , cord-004751-4vl0cvyq 75 21 but but CC cord-004751-4vl0cvyq 75 22 widespread widespread JJ cord-004751-4vl0cvyq 75 23 damage damage NN cord-004751-4vl0cvyq 75 24 occurred occur VBD cord-004751-4vl0cvyq 75 25 by by IN cord-004751-4vl0cvyq 75 26 10 10 CD cord-004751-4vl0cvyq 75 27 - - HYPH cord-004751-4vl0cvyq 75 28 -12 -12 CD cord-004751-4vl0cvyq 75 29 days day NNS cord-004751-4vl0cvyq 75 30 , , , cord-004751-4vl0cvyq 75 31 and and CC cord-004751-4vl0cvyq 75 32 viral viral JJ cord-004751-4vl0cvyq 75 33 growth growth NN cord-004751-4vl0cvyq 75 34 was be VBD cord-004751-4vl0cvyq 75 35 quite quite RB cord-004751-4vl0cvyq 75 36 similar similar JJ cord-004751-4vl0cvyq 75 37 to to IN cord-004751-4vl0cvyq 75 38 the the DT cord-004751-4vl0cvyq 75 39 A A NNP cord-004751-4vl0cvyq 75 40 / / SYM cord-004751-4vl0cvyq 75 41 Eng Eng NNP cord-004751-4vl0cvyq 75 42 . . NNP cord-004751-4vl0cvyq 75 43 parent parent NN cord-004751-4vl0cvyq 75 44 as as IN cord-004751-4vl0cvyq 75 45 shown show VBN cord-004751-4vl0cvyq 75 46 in in IN cord-004751-4vl0cvyq 75 47 Figure figure NN cord-004751-4vl0cvyq 75 48 2 2 CD cord-004751-4vl0cvyq 75 49 . . . cord-004751-4vl0cvyq 76 1 Thus thus RB cord-004751-4vl0cvyq 76 2 , , , cord-004751-4vl0cvyq 76 3 both both DT cord-004751-4vl0cvyq 76 4 by by IN cord-004751-4vl0cvyq 76 5 observation observation NN cord-004751-4vl0cvyq 76 6 of of IN cord-004751-4vl0cvyq 76 7 ciliary ciliary NN cord-004751-4vl0cvyq 76 8 activity activity NN cord-004751-4vl0cvyq 76 9 and and CC cord-004751-4vl0cvyq 76 10 by by IN cord-004751-4vl0cvyq 76 11 titrating titrate VBG cord-004751-4vl0cvyq 76 12 the the DT cord-004751-4vl0cvyq 76 13 virus virus NN cord-004751-4vl0cvyq 76 14 produced produce VBN cord-004751-4vl0cvyq 76 15 , , , cord-004751-4vl0cvyq 76 16 the the DT cord-004751-4vl0cvyq 76 17 viruses virus NNS cord-004751-4vl0cvyq 76 18 fall fall VBP cord-004751-4vl0cvyq 76 19 into into IN cord-004751-4vl0cvyq 76 20 the the DT cord-004751-4vl0cvyq 76 21 order order NN cord-004751-4vl0cvyq 76 22 PR8 PR8 NNP cord-004751-4vl0cvyq 76 23 , , , cord-004751-4vl0cvyq 76 24 64e 64e CD cord-004751-4vl0cvyq 76 25 , , , cord-004751-4vl0cvyq 76 26 6 6 CD cord-004751-4vl0cvyq 76 27 , , , cord-004751-4vl0cvyq 76 28 A A NNP cord-004751-4vl0cvyq 76 29 / / SYM cord-004751-4vl0cvyq 76 30 Eng./939/69 Eng./939/69 NNP cord-004751-4vl0cvyq 76 31 from from IN cord-004751-4vl0cvyq 76 32 the the DT cord-004751-4vl0cvyq 76 33 least least JJS cord-004751-4vl0cvyq 76 34 to to IN cord-004751-4vl0cvyq 76 35 the the DT cord-004751-4vl0cvyq 76 36 most most RBS cord-004751-4vl0cvyq 76 37 virulent virulent JJ cord-004751-4vl0cvyq 76 38 for for IN cord-004751-4vl0cvyq 76 39 cultured cultured JJ cord-004751-4vl0cvyq 76 40 cells cell NNS cord-004751-4vl0cvyq 76 41 . . . cord-004751-4vl0cvyq 77 1 As as IN cord-004751-4vl0cvyq 77 2 shown show VBN cord-004751-4vl0cvyq 77 3 in in IN cord-004751-4vl0cvyq 77 4 Table Table NNP cord-004751-4vl0cvyq 77 5 1 1 CD cord-004751-4vl0cvyq 77 6 , , , cord-004751-4vl0cvyq 77 7 this this DT cord-004751-4vl0cvyq 77 8 corresponds correspond VBZ cord-004751-4vl0cvyq 77 9 exactly exactly RB cord-004751-4vl0cvyq 77 10 to to IN cord-004751-4vl0cvyq 77 11 the the DT cord-004751-4vl0cvyq 77 12 order order NN cord-004751-4vl0cvyq 77 13 of of IN cord-004751-4vl0cvyq 77 14 virulence virulence NN cord-004751-4vl0cvyq 77 15 found find VBN cord-004751-4vl0cvyq 77 16 in in IN cord-004751-4vl0cvyq 77 17 experiments experiment NNS cord-004751-4vl0cvyq 77 18 in in IN cord-004751-4vl0cvyq 77 19 human human JJ cord-004751-4vl0cvyq 77 20 volunteers volunteer NNS cord-004751-4vl0cvyq 77 21 and and CC cord-004751-4vl0cvyq 77 22 recently recently RB cord-004751-4vl0cvyq 77 23 reported report VBN cord-004751-4vl0cvyq 77 24 by by IN cord-004751-4vl0cvyq 77 25 BE BE NNP cord-004751-4vl0cvyq 77 26 ~ ~ NFP cord-004751-4vl0cvyq 77 27 mE mE NNP cord-004751-4vl0cvyq 77 28 and and CC cord-004751-4vl0cvyq 77 29 HALL HALL NNP cord-004751-4vl0cvyq 77 30 ( ( -LRB- cord-004751-4vl0cvyq 77 31 1971 1971 CD cord-004751-4vl0cvyq 77 32 ) ) -RRB- cord-004751-4vl0cvyq 77 33 . . . cord-004751-4vl0cvyq 77 34 _SP cord-004751-4vl0cvyq 78 1 As as IN cord-004751-4vl0cvyq 78 2 shown show VBN cord-004751-4vl0cvyq 78 3 in in IN cord-004751-4vl0cvyq 78 4 Figure Figure NNP cord-004751-4vl0cvyq 78 5 3 3 CD cord-004751-4vl0cvyq 78 6 , , , cord-004751-4vl0cvyq 78 7 it -PRON- PRP cord-004751-4vl0cvyq 78 8 was be VBD cord-004751-4vl0cvyq 78 9 not not RB cord-004751-4vl0cvyq 78 10 possible possible JJ cord-004751-4vl0cvyq 78 11 to to TO cord-004751-4vl0cvyq 78 12 differentiate differentiate VB cord-004751-4vl0cvyq 78 13 the the DT cord-004751-4vl0cvyq 78 14 A A NNP cord-004751-4vl0cvyq 78 15 / / SYM cord-004751-4vl0cvyq 78 16 PR PR NNP cord-004751-4vl0cvyq 78 17 8 8 CD cord-004751-4vl0cvyq 78 18 parent parent NN cord-004751-4vl0cvyq 78 19 from from IN cord-004751-4vl0cvyq 78 20 the the DT cord-004751-4vl0cvyq 78 21 other other JJ cord-004751-4vl0cvyq 78 22 viruses virus NNS cord-004751-4vl0cvyq 78 23 tested test VBN cord-004751-4vl0cvyq 78 24 by by IN cord-004751-4vl0cvyq 78 25 the the DT cord-004751-4vl0cvyq 78 26 effect effect NN cord-004751-4vl0cvyq 78 27 on on IN cord-004751-4vl0cvyq 78 28 cilia cilium NNS cord-004751-4vl0cvyq 78 29 . . . cord-004751-4vl0cvyq 79 1 However however RB cord-004751-4vl0cvyq 79 2 , , , cord-004751-4vl0cvyq 79 3 this this DT cord-004751-4vl0cvyq 79 4 virus virus NN cord-004751-4vl0cvyq 79 5 grew grow VBD cord-004751-4vl0cvyq 79 6 to to IN cord-004751-4vl0cvyq 79 7 low low JJ cord-004751-4vl0cvyq 79 8 titre titre NN cord-004751-4vl0cvyq 79 9 as as IN cord-004751-4vl0cvyq 79 10 it -PRON- PRP cord-004751-4vl0cvyq 79 11 has have VBZ cord-004751-4vl0cvyq 79 12 in in IN cord-004751-4vl0cvyq 79 13 human human JJ cord-004751-4vl0cvyq 79 14 tissue tissue NN cord-004751-4vl0cvyq 79 15 ( ( -LRB- cord-004751-4vl0cvyq 79 16 Table table NN cord-004751-4vl0cvyq 79 17 1 1 CD cord-004751-4vl0cvyq 79 18 ) ) -RRB- cord-004751-4vl0cvyq 79 19 . . . cord-004751-4vl0cvyq 80 1 Although although IN cord-004751-4vl0cvyq 80 2 the the DT cord-004751-4vl0cvyq 80 3 A A NNP cord-004751-4vl0cvyq 80 4 / / SYM cord-004751-4vl0cvyq 80 5 Eng Eng NNP cord-004751-4vl0cvyq 80 6 . . NNP cord-004751-4vl0cvyq 80 7 parent parent NN cord-004751-4vl0cvyq 80 8 destroyed destroy VBD cord-004751-4vl0cvyq 80 9 the the DT cord-004751-4vl0cvyq 80 10 ciliated ciliated JJ cord-004751-4vl0cvyq 80 11 epithelium epithelium NN cord-004751-4vl0cvyq 80 12 of of IN cord-004751-4vl0cvyq 80 13 human human JJ cord-004751-4vl0cvyq 80 14 tissue tissue NN cord-004751-4vl0cvyq 80 15 , , , cord-004751-4vl0cvyq 80 16 it -PRON- PRP cord-004751-4vl0cvyq 80 17 has have VBZ cord-004751-4vl0cvyq 80 18 little little JJ cord-004751-4vl0cvyq 80 19 effect effect NN cord-004751-4vl0cvyq 80 20 on on IN cord-004751-4vl0cvyq 80 21 ferret ferret JJ cord-004751-4vl0cvyq 80 22 trachea trachea NN cord-004751-4vl0cvyq 80 23 . . . cord-004751-4vl0cvyq 81 1 In in IN cord-004751-4vl0cvyq 81 2 one one CD cord-004751-4vl0cvyq 81 3 experiment experiment NN cord-004751-4vl0cvyq 81 4 in in IN cord-004751-4vl0cvyq 81 5 which which WDT cord-004751-4vl0cvyq 81 6 cultures culture NNS cord-004751-4vl0cvyq 81 7 were be VBD cord-004751-4vl0cvyq 81 8 held hold VBN cord-004751-4vl0cvyq 81 9 for for IN cord-004751-4vl0cvyq 81 10 a a DT cord-004751-4vl0cvyq 81 11 long long JJ cord-004751-4vl0cvyq 81 12 time time NN cord-004751-4vl0cvyq 81 13 , , , cord-004751-4vl0cvyq 81 14 the the DT cord-004751-4vl0cvyq 81 15 eiliated eiliated JJ cord-004751-4vl0cvyq 81 16 epithelium epithelium NN cord-004751-4vl0cvyq 81 17 was be VBD cord-004751-4vl0cvyq 81 18 destroyed destroy VBN cord-004751-4vl0cvyq 81 19 after after IN cord-004751-4vl0cvyq 81 20 about about RB cord-004751-4vl0cvyq 81 21 three three CD cord-004751-4vl0cvyq 81 22 weeks week NNS cord-004751-4vl0cvyq 81 23 . . . cord-004751-4vl0cvyq 82 1 Furthermore furthermore RB cord-004751-4vl0cvyq 82 2 , , , cord-004751-4vl0cvyq 82 3 the the DT cord-004751-4vl0cvyq 82 4 A A NNP cord-004751-4vl0cvyq 82 5 / / SYM cord-004751-4vl0cvyq 82 6 Eng Eng NNP cord-004751-4vl0cvyq 82 7 . . . cord-004751-4vl0cvyq 83 1 virus virus NN cord-004751-4vl0cvyq 83 2 multiplied multiply VBD cord-004751-4vl0cvyq 83 3 to to IN cord-004751-4vl0cvyq 83 4 high high JJ cord-004751-4vl0cvyq 83 5 titre titre NN cord-004751-4vl0cvyq 83 6 , , , cord-004751-4vl0cvyq 83 7 range range NN cord-004751-4vl0cvyq 83 8 from from IN cord-004751-4vl0cvyq 83 9 108.16 108.16 CD cord-004751-4vl0cvyq 83 10 to to IN cord-004751-4vl0cvyq 83 11 106.2EID50 106.2eid50 CD cord-004751-4vl0cvyq 83 12 / / SYM cord-004751-4vl0cvyq 83 13 ml ml NN cord-004751-4vl0cvyq 83 14 at at IN cord-004751-4vl0cvyq 83 15 5 5 CD cord-004751-4vl0cvyq 83 16 days day NNS cord-004751-4vl0cvyq 83 17 . . . cord-004751-4vl0cvyq 84 1 The the DT cord-004751-4vl0cvyq 84 2 recombinant recombinant JJ cord-004751-4vl0cvyq 84 3 viruses virus NNS cord-004751-4vl0cvyq 84 4 did do VBD cord-004751-4vl0cvyq 84 5 not not RB cord-004751-4vl0cvyq 84 6 cause cause VB cord-004751-4vl0cvyq 84 7 ciliary ciliary NN cord-004751-4vl0cvyq 84 8 damage damage NN cord-004751-4vl0cvyq 84 9 , , , cord-004751-4vl0cvyq 84 10 but but CC cord-004751-4vl0cvyq 84 11 at at IN cord-004751-4vl0cvyq 84 12 5 5 CD cord-004751-4vl0cvyq 84 13 days day NNS cord-004751-4vl0cvyq 84 14 the the DT cord-004751-4vl0cvyq 84 15 growth growth NN cord-004751-4vl0cvyq 84 16 in in IN cord-004751-4vl0cvyq 84 17 ferret ferret JJ cord-004751-4vl0cvyq 84 18 epithelium epithelium NN cord-004751-4vl0cvyq 84 19 was be VBD cord-004751-4vl0cvyq 84 20 similar similar JJ cord-004751-4vl0cvyq 84 21 to to IN cord-004751-4vl0cvyq 84 22 that that DT cord-004751-4vl0cvyq 84 23 in in IN cord-004751-4vl0cvyq 84 24 human human JJ cord-004751-4vl0cvyq 84 25 tissue tissue NN cord-004751-4vl0cvyq 84 26 . . . cord-004751-4vl0cvyq 85 1 In in IN cord-004751-4vl0cvyq 85 2 other other JJ cord-004751-4vl0cvyq 85 3 words word NNS cord-004751-4vl0cvyq 85 4 , , , cord-004751-4vl0cvyq 85 5 clone clone NN cord-004751-4vl0cvyq 85 6 64c 64c NNS cord-004751-4vl0cvyq 85 7 attained attain VBD cord-004751-4vl0cvyq 85 8 titres titre NNS cord-004751-4vl0cvyq 85 9 ( ( -LRB- cord-004751-4vl0cvyq 85 10 range range VBP cord-004751-4vl0cvyq 85 11 at at IN cord-004751-4vl0cvyq 85 12 5 5 CD cord-004751-4vl0cvyq 85 13 days day NNS cord-004751-4vl0cvyq 85 14 103.5 103.5 CD cord-004751-4vl0cvyq 85 15 to to IN cord-004751-4vl0cvyq 85 16 104.4EIDs0 104.4EIDs0 NNP cord-004751-4vl0cvyq 85 17 / / SYM cord-004751-4vl0cvyq 85 18 ml ml NN cord-004751-4vl0cvyq 85 19 ) ) -RRB- cord-004751-4vl0cvyq 85 20 similar similar JJ cord-004751-4vl0cvyq 85 21 to to IN cord-004751-4vl0cvyq 85 22 the the DT cord-004751-4vl0cvyq 85 23 A A NNP cord-004751-4vl0cvyq 85 24 / / SYM cord-004751-4vl0cvyq 85 25 PR8 PR8 NNP cord-004751-4vl0cvyq 85 26 parent parent NN cord-004751-4vl0cvyq 85 27 , , , cord-004751-4vl0cvyq 85 28 and and CC cord-004751-4vl0cvyq 85 29 clone clone NN cord-004751-4vl0cvyq 85 30 6 6 CD cord-004751-4vl0cvyq 85 31 attained attain VBN cord-004751-4vl0cvyq 85 32 titres titre NNS cord-004751-4vl0cvyq 85 33 ( ( -LRB- cord-004751-4vl0cvyq 85 34 range range VBP cord-004751-4vl0cvyq 85 35 at at IN cord-004751-4vl0cvyq 85 36 5 5 CD cord-004751-4vl0cvyq 85 37 days day NNS cord-004751-4vl0cvyq 85 38 104.5 104.5 CD cord-004751-4vl0cvyq 85 39 to to IN cord-004751-4vl0cvyq 85 40 105 105 CD cord-004751-4vl0cvyq 85 41 - - SYM cord-004751-4vl0cvyq 85 42 5EID50 5eid50 CD cord-004751-4vl0cvyq 86 1 /ml /ml NFP cord-004751-4vl0cvyq 86 2 ) ) -RRB- cord-004751-4vl0cvyq 86 3 similar similar JJ cord-004751-4vl0cvyq 86 4 to to IN cord-004751-4vl0cvyq 86 5 the the DT cord-004751-4vl0cvyq 86 6 A A NNP cord-004751-4vl0cvyq 86 7 / / SYM cord-004751-4vl0cvyq 86 8 Eng Eng NNP cord-004751-4vl0cvyq 86 9 . . NNP cord-004751-4vl0cvyq 86 10 parent parent NN cord-004751-4vl0cvyq 86 11 . . . cord-004751-4vl0cvyq 87 1 Since since IN cord-004751-4vl0cvyq 87 2 the the DT cord-004751-4vl0cvyq 87 3 differences difference NNS cord-004751-4vl0cvyq 87 4 in in IN cord-004751-4vl0cvyq 87 5 the the DT cord-004751-4vl0cvyq 87 6 behaviour behaviour NN cord-004751-4vl0cvyq 87 7 of of IN cord-004751-4vl0cvyq 87 8 the the DT cord-004751-4vl0cvyq 87 9 viruses virus NNS cord-004751-4vl0cvyq 87 10 might may MD cord-004751-4vl0cvyq 87 11 have have VB cord-004751-4vl0cvyq 87 12 been be VBN cord-004751-4vl0cvyq 87 13 related relate VBN cord-004751-4vl0cvyq 87 14 to to IN cord-004751-4vl0cvyq 87 15 the the DT cord-004751-4vl0cvyq 87 16 fact fact NN cord-004751-4vl0cvyq 87 17 that that IN cord-004751-4vl0cvyq 87 18 they -PRON- PRP cord-004751-4vl0cvyq 87 19 were be VBD cord-004751-4vl0cvyq 87 20 prepared prepare VBN cord-004751-4vl0cvyq 87 21 by by IN cord-004751-4vl0cvyq 87 22 recombination recombination NN cord-004751-4vl0cvyq 87 23 , , , cord-004751-4vl0cvyq 87 24 rather rather RB cord-004751-4vl0cvyq 87 25 than than IN cord-004751-4vl0cvyq 87 26 to to IN cord-004751-4vl0cvyq 87 27 the the DT cord-004751-4vl0cvyq 87 28 attenua- attenua- NNS cord-004751-4vl0cvyq 87 29 _SP cord-004751-4vl0cvyq 88 1 Even even RB cord-004751-4vl0cvyq 88 2 when when WRB cord-004751-4vl0cvyq 88 3 optimally optimally RB cord-004751-4vl0cvyq 88 4 constituted constitute VBD cord-004751-4vl0cvyq 88 5 , , , cord-004751-4vl0cvyq 88 6 the the DT cord-004751-4vl0cvyq 88 7 usual usual JJ cord-004751-4vl0cvyq 88 8 doses dose NNS cord-004751-4vl0cvyq 88 9 of of IN cord-004751-4vl0cvyq 88 10 inactivated inactivate VBN cord-004751-4vl0cvyq 88 11 influenza influenza NN cord-004751-4vl0cvyq 88 12 virus virus NN cord-004751-4vl0cvyq 88 13 vaccines vaccine NNS cord-004751-4vl0cvyq 88 14 are be VBP cord-004751-4vl0cvyq 88 15 variably variably RB cord-004751-4vl0cvyq 88 16 effective effective JJ cord-004751-4vl0cvyq 88 17 in in IN cord-004751-4vl0cvyq 88 18 preventing prevent VBG cord-004751-4vl0cvyq 88 19 disease disease NN cord-004751-4vl0cvyq 88 20 ( ( -LRB- cord-004751-4vl0cvyq 88 21 SeHoENBAUM SeHoENBAUM NNP cord-004751-4vl0cvyq 88 22 , , , cord-004751-4vl0cvyq 88 23 MOSTOW MOSTOW NNP cord-004751-4vl0cvyq 88 24 , , , cord-004751-4vl0cvyq 88 25 DOWDL]~ DOWDL]~ NNP cord-004751-4vl0cvyq 88 26 , , , cord-004751-4vl0cvyq 88 27 CO CO NNP cord-004751-4vl0cvyq 88 28 ] ] -RRB- cord-004751-4vl0cvyq 88 29 ~AN ~AN NNP cord-004751-4vl0cvyq 88 30 and and CC cord-004751-4vl0cvyq 88 31 KAYE KAYE NNP cord-004751-4vl0cvyq 88 32 , , , cord-004751-4vl0cvyq 88 33 1969 1969 CD cord-004751-4vl0cvyq 88 34 ) ) -RRB- cord-004751-4vl0cvyq 88 35 . . . cord-004751-4vl0cvyq 89 1 Live live JJ cord-004751-4vl0cvyq 89 2 attenuated attenuated JJ cord-004751-4vl0cvyq 89 3 vaccines vaccine NNS cord-004751-4vl0cvyq 89 4 are be VBP cord-004751-4vl0cvyq 89 5 a a DT cord-004751-4vl0cvyq 89 6 possible possible JJ cord-004751-4vl0cvyq 89 7 alternative alternative NN cord-004751-4vl0cvyq 89 8 but but CC cord-004751-4vl0cvyq 89 9 before before IN cord-004751-4vl0cvyq 89 10 they -PRON- PRP cord-004751-4vl0cvyq 89 11 can can MD cord-004751-4vl0cvyq 89 12 be be VB cord-004751-4vl0cvyq 89 13 introduced introduce VBN cord-004751-4vl0cvyq 89 14 it -PRON- PRP cord-004751-4vl0cvyq 89 15 is be VBZ cord-004751-4vl0cvyq 89 16 necessary necessary JJ cord-004751-4vl0cvyq 89 17 to to TO cord-004751-4vl0cvyq 89 18 be be VB cord-004751-4vl0cvyq 89 19 able able JJ cord-004751-4vl0cvyq 89 20 to to TO cord-004751-4vl0cvyq 89 21 obtain obtain VB cord-004751-4vl0cvyq 89 22 rapidly rapidly RB cord-004751-4vl0cvyq 89 23 and and CC cord-004751-4vl0cvyq 89 24 reproducibly reproducibly RB cord-004751-4vl0cvyq 89 25 from from IN cord-004751-4vl0cvyq 89 26 wild wild JJ cord-004751-4vl0cvyq 89 27 virus virus NN cord-004751-4vl0cvyq 89 28 , , , cord-004751-4vl0cvyq 89 29 strains strain NNS cord-004751-4vl0cvyq 89 30 which which WDT cord-004751-4vl0cvyq 89 31 grow grow VBP cord-004751-4vl0cvyq 89 32 to to IN cord-004751-4vl0cvyq 89 33 high high JJ cord-004751-4vl0cvyq 89 34 titre titre NN cord-004751-4vl0cvyq 89 35 in in IN cord-004751-4vl0cvyq 89 36 eggs egg NNS cord-004751-4vl0cvyq 89 37 and and CC cord-004751-4vl0cvyq 89 38 which which WDT cord-004751-4vl0cvyq 89 39 are be VBP cord-004751-4vl0cvyq 89 40 a a DT cord-004751-4vl0cvyq 89 41 attenuated attenuated JJ cord-004751-4vl0cvyq 89 42 for for IN cord-004751-4vl0cvyq 89 43 man man NN cord-004751-4vl0cvyq 89 44 . . . cord-004751-4vl0cvyq 90 1 It -PRON- PRP cord-004751-4vl0cvyq 90 2 is be VBZ cord-004751-4vl0cvyq 90 3 generally generally RB cord-004751-4vl0cvyq 90 4 believed believe VBN cord-004751-4vl0cvyq 90 5 that that IN cord-004751-4vl0cvyq 90 6 virulence virulence NN cord-004751-4vl0cvyq 90 7 is be VBZ cord-004751-4vl0cvyq 90 8 determined determine VBN cord-004751-4vl0cvyq 90 9 by by IN cord-004751-4vl0cvyq 90 10 multiple multiple JJ cord-004751-4vl0cvyq 90 11 genes gene NNS cord-004751-4vl0cvyq 90 12 and and CC cord-004751-4vl0cvyq 90 13 KILBOURNE KILBOURNE NNP cord-004751-4vl0cvyq 90 14 ( ( -LRB- cord-004751-4vl0cvyq 90 15 1969 1969 CD cord-004751-4vl0cvyq 90 16 ) ) -RRB- cord-004751-4vl0cvyq 90 17 suggested suggest VBD cord-004751-4vl0cvyq 90 18 that that IN cord-004751-4vl0cvyq 90 19 recombining recombine VBG cord-004751-4vl0cvyq 90 20 a a DT cord-004751-4vl0cvyq 90 21 virulent virulent JJ cord-004751-4vl0cvyq 90 22 strain strain NN cord-004751-4vl0cvyq 90 23 with with IN cord-004751-4vl0cvyq 90 24 an an DT cord-004751-4vl0cvyq 90 25 avirulent avirulent NN cord-004751-4vl0cvyq 90 26 one one PRP cord-004751-4vl0cvyq 90 27 would would MD cord-004751-4vl0cvyq 90 28 give give VB cord-004751-4vl0cvyq 90 29 progeny progeny NN cord-004751-4vl0cvyq 90 30 with with IN cord-004751-4vl0cvyq 90 31 intermediate intermediate JJ cord-004751-4vl0cvyq 90 32 virulence virulence NN cord-004751-4vl0cvyq 90 33 and and CC cord-004751-4vl0cvyq 90 34 might may MD cord-004751-4vl0cvyq 90 35 therefore therefore RB cord-004751-4vl0cvyq 90 36 be be VB cord-004751-4vl0cvyq 90 37 used use VBN cord-004751-4vl0cvyq 90 38 as as IN cord-004751-4vl0cvyq 90 39 a a DT cord-004751-4vl0cvyq 90 40 means means NN cord-004751-4vl0cvyq 90 41 of of IN cord-004751-4vl0cvyq 90 42 simultaneous simultaneous JJ cord-004751-4vl0cvyq 90 43 " " `` cord-004751-4vl0cvyq 90 44 instant instant JJ cord-004751-4vl0cvyq 90 45 " " '' cord-004751-4vl0cvyq 90 46 attenuation attenuation NN cord-004751-4vl0cvyq 90 47 and and CC cord-004751-4vl0cvyq 90 48 adaptation adaptation NN cord-004751-4vl0cvyq 90 49 to to IN cord-004751-4vl0cvyq 90 50 eggs egg NNS cord-004751-4vl0cvyq 90 51 . . . cord-004751-4vl0cvyq 91 1 This this DT cord-004751-4vl0cvyq 91 2 has have VBZ cord-004751-4vl0cvyq 91 3 been be VBN cord-004751-4vl0cvyq 91 4 shown show VBN cord-004751-4vl0cvyq 91 5 to to TO cord-004751-4vl0cvyq 91 6 be be VB cord-004751-4vl0cvyq 91 7 possible possible JJ cord-004751-4vl0cvyq 91 8 but but CC cord-004751-4vl0cvyq 91 9 two two CD cord-004751-4vl0cvyq 91 10 of of IN cord-004751-4vl0cvyq 91 11 four four CD cord-004751-4vl0cvyq 91 12 reeombinants reeombinant NNS cord-004751-4vl0cvyq 91 13 were be VBD cord-004751-4vl0cvyq 91 14 inadequately inadequately RB cord-004751-4vl0cvyq 91 15 attenuated attenuated JJ cord-004751-4vl0cvyq 91 16 ( ( -LRB- cord-004751-4vl0cvyq 91 17 BEARE BEARE NNP cord-004751-4vl0cvyq 91 18 and and CC cord-004751-4vl0cvyq 91 19 HALL HALL NNP cord-004751-4vl0cvyq 91 20 , , , cord-004751-4vl0cvyq 91 21 1971 1971 CD cord-004751-4vl0cvyq 91 22 ) ) -RRB- cord-004751-4vl0cvyq 91 23 and and CC cord-004751-4vl0cvyq 91 24 it -PRON- PRP cord-004751-4vl0cvyq 91 25 would would MD cord-004751-4vl0cvyq 91 26 therefore therefore RB cord-004751-4vl0cvyq 91 27 be be VB cord-004751-4vl0cvyq 91 28 useful useful JJ cord-004751-4vl0cvyq 91 29 to to TO cord-004751-4vl0cvyq 91 30 be be VB cord-004751-4vl0cvyq 91 31 able able JJ cord-004751-4vl0cvyq 91 32 to to TO cord-004751-4vl0cvyq 91 33 distinguish distinguish VB cord-004751-4vl0cvyq 91 34 attenuated attenuated JJ cord-004751-4vl0cvyq 91 35 reeombinants reeombinant NNS cord-004751-4vl0cvyq 91 36 in in IN cord-004751-4vl0cvyq 91 37 the the DT cord-004751-4vl0cvyq 91 38 laboratory laboratory NN cord-004751-4vl0cvyq 91 39 . . . cord-004751-4vl0cvyq 92 1 The the DT cord-004751-4vl0cvyq 92 2 method method NN cord-004751-4vl0cvyq 92 3 of of IN cord-004751-4vl0cvyq 92 4 evaluation evaluation NN cord-004751-4vl0cvyq 92 5 in in IN cord-004751-4vl0cvyq 92 6 organ organ NN cord-004751-4vl0cvyq 92 7 culture culture NN cord-004751-4vl0cvyq 92 8 seems seem VBZ cord-004751-4vl0cvyq 92 9 to to TO cord-004751-4vl0cvyq 92 10 give give VB cord-004751-4vl0cvyq 92 11 repeatable repeatable JJ cord-004751-4vl0cvyq 92 12 and and CC cord-004751-4vl0cvyq 92 13 consistent consistent JJ cord-004751-4vl0cvyq 92 14 results result NNS cord-004751-4vl0cvyq 92 15 as as IN cord-004751-4vl0cvyq 92 16 was be VBD cord-004751-4vl0cvyq 92 17 noticed notice VBN cord-004751-4vl0cvyq 92 18 in in IN cord-004751-4vl0cvyq 92 19 a a DT cord-004751-4vl0cvyq 92 20 preliminary preliminary JJ cord-004751-4vl0cvyq 92 21 paper paper NN cord-004751-4vl0cvyq 92 22 ( ( -LRB- cord-004751-4vl0cvyq 92 23 MosTow MosTow NNP cord-004751-4vl0cvyq 92 24 and and CC cord-004751-4vl0cvyq 92 25 TYRRWLL TYRRWLL NNP cord-004751-4vl0cvyq 92 26 , , , cord-004751-4vl0cvyq 92 27 1972 1972 CD cord-004751-4vl0cvyq 92 28 ) ) -RRB- cord-004751-4vl0cvyq 92 29 . . . cord-004751-4vl0cvyq 93 1 This this DT cord-004751-4vl0cvyq 93 2 paper paper NN cord-004751-4vl0cvyq 93 3 reports report VBZ cord-004751-4vl0cvyq 93 4 further further JJ cord-004751-4vl0cvyq 93 5 results result NNS cord-004751-4vl0cvyq 93 6 and and CC cord-004751-4vl0cvyq 93 7 a a DT cord-004751-4vl0cvyq 93 8 number number NN cord-004751-4vl0cvyq 93 9 of of IN cord-004751-4vl0cvyq 93 10 important important JJ cord-004751-4vl0cvyq 93 11 points point NNS cord-004751-4vl0cvyq 93 12 of of IN cord-004751-4vl0cvyq 93 13 technique technique NN cord-004751-4vl0cvyq 93 14 . . . cord-004751-4vl0cvyq 94 1 There there EX cord-004751-4vl0cvyq 94 2 appears appear VBZ cord-004751-4vl0cvyq 94 3 also also RB cord-004751-4vl0cvyq 94 4 to to TO cord-004751-4vl0cvyq 94 5 be be VB cord-004751-4vl0cvyq 94 6 some some DT cord-004751-4vl0cvyq 94 7 variability variability NN cord-004751-4vl0cvyq 94 8 in in IN cord-004751-4vl0cvyq 94 9 the the DT cord-004751-4vl0cvyq 94 10 susceptibility susceptibility NN cord-004751-4vl0cvyq 94 11 of of IN cord-004751-4vl0cvyq 94 12 different different JJ cord-004751-4vl0cvyq 94 13 tracheas trachea NNS cord-004751-4vl0cvyq 94 14 . . . cord-004751-4vl0cvyq 95 1 The the DT cord-004751-4vl0cvyq 95 2 data datum NNS cord-004751-4vl0cvyq 95 3 were be VBD cord-004751-4vl0cvyq 95 4 pooled pool VBN cord-004751-4vl0cvyq 95 5 for for IN cord-004751-4vl0cvyq 95 6 this this DT cord-004751-4vl0cvyq 95 7 report report NN cord-004751-4vl0cvyq 95 8 , , , cord-004751-4vl0cvyq 95 9 but but CC cord-004751-4vl0cvyq 95 10 nevertheless nevertheless RB cord-004751-4vl0cvyq 95 11 each each DT cord-004751-4vl0cvyq 95 12 individual individual JJ cord-004751-4vl0cvyq 95 13 experiment experiment NN cord-004751-4vl0cvyq 95 14 ranked rank VBD cord-004751-4vl0cvyq 95 15 the the DT cord-004751-4vl0cvyq 95 16 viruses virus NNS cord-004751-4vl0cvyq 95 17 in in IN cord-004751-4vl0cvyq 95 18 the the DT cord-004751-4vl0cvyq 95 19 same same JJ cord-004751-4vl0cvyq 95 20 order order NN cord-004751-4vl0cvyq 95 21 ; ; : cord-004751-4vl0cvyq 95 22 however however RB cord-004751-4vl0cvyq 95 23 , , , cord-004751-4vl0cvyq 95 24 we -PRON- PRP cord-004751-4vl0cvyq 95 25 think think VBP cord-004751-4vl0cvyq 95 26 it -PRON- PRP cord-004751-4vl0cvyq 95 27 is be VBZ cord-004751-4vl0cvyq 95 28 important important JJ cord-004751-4vl0cvyq 95 29 to to TO cord-004751-4vl0cvyq 95 30 include include VB cord-004751-4vl0cvyq 95 31 the the DT cord-004751-4vl0cvyq 95 32 virulent virulent JJ cord-004751-4vl0cvyq 95 33 and and CC cord-004751-4vl0cvyq 95 34 attenuated attenuated JJ cord-004751-4vl0cvyq 95 35 parent parent NN cord-004751-4vl0cvyq 95 36 in in IN cord-004751-4vl0cvyq 95 37 each each DT cord-004751-4vl0cvyq 95 38 test test NN cord-004751-4vl0cvyq 95 39 as as IN cord-004751-4vl0cvyq 95 40 controls control NNS cord-004751-4vl0cvyq 95 41 . . . cord-004751-4vl0cvyq 96 1 Using use VBG cord-004751-4vl0cvyq 96 2 the the DT cord-004751-4vl0cvyq 96 3 technique technique NN cord-004751-4vl0cvyq 96 4 described describe VBN cord-004751-4vl0cvyq 96 5 , , , cord-004751-4vl0cvyq 96 6 there there EX cord-004751-4vl0cvyq 96 7 was be VBD cord-004751-4vl0cvyq 96 8 a a DT cord-004751-4vl0cvyq 96 9 clear clear JJ cord-004751-4vl0cvyq 96 10 correlation correlation NN cord-004751-4vl0cvyq 96 11 between between IN cord-004751-4vl0cvyq 96 12 free free JJ cord-004751-4vl0cvyq 96 13 growth growth NN cord-004751-4vl0cvyq 96 14 in in IN cord-004751-4vl0cvyq 96 15 organ organ NN cord-004751-4vl0cvyq 96 16 culture culture NN cord-004751-4vl0cvyq 96 17 , , , cord-004751-4vl0cvyq 96 18 damage damage NN cord-004751-4vl0cvyq 96 19 to to IN cord-004751-4vl0cvyq 96 20 cells cell NNS cord-004751-4vl0cvyq 96 21 and and CC cord-004751-4vl0cvyq 96 22 the the DT cord-004751-4vl0cvyq 96 23 ability ability NN cord-004751-4vl0cvyq 96 24 to to TO cord-004751-4vl0cvyq 96 25 produce produce VB cord-004751-4vl0cvyq 96 26 disease disease NN cord-004751-4vl0cvyq 96 27 in in IN cord-004751-4vl0cvyq 96 28 man man NN cord-004751-4vl0cvyq 96 29 . . . cord-004751-4vl0cvyq 97 1 We -PRON- PRP cord-004751-4vl0cvyq 97 2 do do VBP cord-004751-4vl0cvyq 97 3 not not RB cord-004751-4vl0cvyq 97 4 know know VB cord-004751-4vl0cvyq 97 5 whether whether IN cord-004751-4vl0cvyq 97 6 this this DT cord-004751-4vl0cvyq 97 7 correlation correlation NN cord-004751-4vl0cvyq 97 8 would would MD cord-004751-4vl0cvyq 97 9 hold hold VB cord-004751-4vl0cvyq 97 10 with with IN cord-004751-4vl0cvyq 97 11 tracheas trachea NNS cord-004751-4vl0cvyq 97 12 from from IN cord-004751-4vl0cvyq 97 13 other other JJ cord-004751-4vl0cvyq 97 14 species specie NNS cord-004751-4vl0cvyq 97 15 , , , cord-004751-4vl0cvyq 97 16 if if IN cord-004751-4vl0cvyq 97 17 not not RB cord-004751-4vl0cvyq 97 18 , , , cord-004751-4vl0cvyq 97 19 there there EX cord-004751-4vl0cvyq 97 20 could could MD cord-004751-4vl0cvyq 97 21 be be VB cord-004751-4vl0cvyq 97 22 difficulty difficulty NN cord-004751-4vl0cvyq 97 23 using use VBG cord-004751-4vl0cvyq 97 24 the the DT cord-004751-4vl0cvyq 97 25 test test NN cord-004751-4vl0cvyq 97 26 because because IN cord-004751-4vl0cvyq 97 27 of of IN cord-004751-4vl0cvyq 97 28 lack lack NN cord-004751-4vl0cvyq 97 29 of of IN cord-004751-4vl0cvyq 97 30 an an DT cord-004751-4vl0cvyq 97 31 adequate adequate JJ cord-004751-4vl0cvyq 97 32 supply supply NN cord-004751-4vl0cvyq 97 33 of of IN cord-004751-4vl0cvyq 97 34 suitable suitable JJ cord-004751-4vl0cvyq 97 35 human human JJ cord-004751-4vl0cvyq 97 36 tracheal tracheal NN cord-004751-4vl0cvyq 97 37 cultures culture NNS cord-004751-4vl0cvyq 97 38 ( ( -LRB- cord-004751-4vl0cvyq 97 39 SHAAFF SHAAFF NNP cord-004751-4vl0cvyq 97 40 , , , cord-004751-4vl0cvyq 97 41 BOSWELL BOSWELL NNP cord-004751-4vl0cvyq 97 42 and and CC cord-004751-4vl0cvyq 97 43 MUFSON MUFSON NNP cord-004751-4vl0cvyq 97 44 , , , cord-004751-4vl0cvyq 97 45 1971 1971 CD cord-004751-4vl0cvyq 97 46 ) ) -RRB- cord-004751-4vl0cvyq 97 47 . . . cord-004751-4vl0cvyq 98 1 Our -PRON- PRP$ cord-004751-4vl0cvyq 98 2 results result NNS cord-004751-4vl0cvyq 98 3 with with IN cord-004751-4vl0cvyq 98 4 the the DT cord-004751-4vl0cvyq 98 5 parental parental JJ cord-004751-4vl0cvyq 98 6 strains strain NNS cord-004751-4vl0cvyq 98 7 of of IN cord-004751-4vl0cvyq 98 8 influenza influenza NN cord-004751-4vl0cvyq 98 9 were be VBD cord-004751-4vl0cvyq 98 10 not not RB cord-004751-4vl0cvyq 98 11 particularly particularly RB cord-004751-4vl0cvyq 98 12 surprising surprising JJ cord-004751-4vl0cvyq 98 13 . . . cord-004751-4vl0cvyq 99 1 The the DT cord-004751-4vl0cvyq 99 2 basic basic JJ cord-004751-4vl0cvyq 99 3 pathology pathology NN cord-004751-4vl0cvyq 99 4 of of IN cord-004751-4vl0cvyq 99 5 the the DT cord-004751-4vl0cvyq 99 6 disease disease NN cord-004751-4vl0cvyq 99 7 is be VBZ cord-004751-4vl0cvyq 99 8 damage damage NN cord-004751-4vl0cvyq 99 9 of of IN cord-004751-4vl0cvyq 99 10 the the DT cord-004751-4vl0cvyq 99 11 tracheal tracheal JJ cord-004751-4vl0cvyq 99 12 cells cell NNS cord-004751-4vl0cvyq 99 13 by by IN cord-004751-4vl0cvyq 99 14 the the DT cord-004751-4vl0cvyq 99 15 virus virus NN cord-004751-4vl0cvyq 99 16 and and CC cord-004751-4vl0cvyq 99 17 since since IN cord-004751-4vl0cvyq 99 18 the the DT cord-004751-4vl0cvyq 99 19 laboratory laboratory NN cord-004751-4vl0cvyq 99 20 adapted adapt VBD cord-004751-4vl0cvyq 99 21 strain strain NN cord-004751-4vl0cvyq 99 22 , , , cord-004751-4vl0cvyq 99 23 A A NNP cord-004751-4vl0cvyq 99 24 / / SYM cord-004751-4vl0cvyq 99 25 PR PR NNP cord-004751-4vl0cvyq 99 26 8/34 8/34 NNP cord-004751-4vl0cvyq 99 27 , , , cord-004751-4vl0cvyq 99 28 does do VBZ cord-004751-4vl0cvyq 99 29 not not RB cord-004751-4vl0cvyq 99 30 cause cause VB cord-004751-4vl0cvyq 99 31 disease disease NN cord-004751-4vl0cvyq 99 32 in in IN cord-004751-4vl0cvyq 99 33 humans human NNS cord-004751-4vl0cvyq 99 34 , , , cord-004751-4vl0cvyq 99 35 we -PRON- PRP cord-004751-4vl0cvyq 99 36 did do VBD cord-004751-4vl0cvyq 99 37 not not RB cord-004751-4vl0cvyq 99 38 expect expect VB cord-004751-4vl0cvyq 99 39 it -PRON- PRP cord-004751-4vl0cvyq 99 40 to to TO cord-004751-4vl0cvyq 99 41 damage damage VB cord-004751-4vl0cvyq 99 42 the the DT cord-004751-4vl0cvyq 99 43 eiliated eiliate VBN cord-004751-4vl0cvyq 99 44 epithelium epithelium NN cord-004751-4vl0cvyq 99 45 from from IN cord-004751-4vl0cvyq 99 46 man man NN cord-004751-4vl0cvyq 99 47 . . . cord-004751-4vl0cvyq 100 1 Nevertheless nevertheless RB cord-004751-4vl0cvyq 100 2 , , , cord-004751-4vl0cvyq 100 3 the the DT cord-004751-4vl0cvyq 100 4 cultures culture NNS cord-004751-4vl0cvyq 100 5 were be VBD cord-004751-4vl0cvyq 100 6 infected infect VBN cord-004751-4vl0cvyq 100 7 whereas whereas IN cord-004751-4vl0cvyq 100 8 the the DT cord-004751-4vl0cvyq 100 9 volunteers volunteer NNS cord-004751-4vl0cvyq 100 10 often often RB cord-004751-4vl0cvyq 100 11 were be VBD cord-004751-4vl0cvyq 100 12 not not RB cord-004751-4vl0cvyq 100 13 . . . cord-004751-4vl0cvyq 101 1 Conversely conversely RB cord-004751-4vl0cvyq 101 2 , , , cord-004751-4vl0cvyq 101 3 recently recently RB cord-004751-4vl0cvyq 101 4 isolated isolate VBN cord-004751-4vl0cvyq 101 5 influenza influenza NN cord-004751-4vl0cvyq 101 6 A a DT cord-004751-4vl0cvyq 101 7 strains strain NNS cord-004751-4vl0cvyq 101 8 cause cause VBP cord-004751-4vl0cvyq 101 9 clinical clinical JJ cord-004751-4vl0cvyq 101 10 influenza influenza NN cord-004751-4vl0cvyq 101 11 and and CC cord-004751-4vl0cvyq 101 12 would would MD cord-004751-4vl0cvyq 101 13 be be VB cord-004751-4vl0cvyq 101 14 expected expect VBN cord-004751-4vl0cvyq 101 15 to to TO cord-004751-4vl0cvyq 101 16 destroy destroy VB cord-004751-4vl0cvyq 101 17 eiliated eiliated NNP cord-004751-4vl0cvyq 101 18 epitholium epitholium NNP cord-004751-4vl0cvyq 101 19 . . . cord-004751-4vl0cvyq 102 1 It -PRON- PRP cord-004751-4vl0cvyq 102 2 has have VBZ cord-004751-4vl0cvyq 102 3 been be VBN cord-004751-4vl0cvyq 102 4 shown show VBN cord-004751-4vl0cvyq 102 5 that that IN cord-004751-4vl0cvyq 102 6 influenza influenza NN cord-004751-4vl0cvyq 102 7 viruses virus NNS cord-004751-4vl0cvyq 102 8 which which WDT cord-004751-4vl0cvyq 102 9 have have VBP cord-004751-4vl0cvyq 102 10 squired squire VBN cord-004751-4vl0cvyq 102 11 ts ts NN cord-004751-4vl0cvyq 102 12 markers marker NNS cord-004751-4vl0cvyq 102 13 as as IN cord-004751-4vl0cvyq 102 14 a a DT cord-004751-4vl0cvyq 102 15 result result NN cord-004751-4vl0cvyq 102 16 of of IN cord-004751-4vl0cvyq 102 17 recombination recombination NN cord-004751-4vl0cvyq 102 18 with with IN cord-004751-4vl0cvyq 102 19 mutagen mutagen NN cord-004751-4vl0cvyq 102 20 - - HYPH cord-004751-4vl0cvyq 102 21 treated treat VBN cord-004751-4vl0cvyq 102 22 strains strain NNS cord-004751-4vl0cvyq 102 23 are be VBP cord-004751-4vl0cvyq 102 24 attenuated attenuate VBN cord-004751-4vl0cvyq 102 25 for for IN cord-004751-4vl0cvyq 102 26 man man NN cord-004751-4vl0cvyq 102 27 ( ( -LRB- cord-004751-4vl0cvyq 102 28 C c NN cord-004751-4vl0cvyq 102 29 ~ ~ NFP cord-004751-4vl0cvyq 102 30 ANOCK ANOCK NNP cord-004751-4vl0cvyq 102 31 , , , cord-004751-4vl0cvyq 102 32 personal personal JJ cord-004751-4vl0cvyq 102 33 communication communication NN cord-004751-4vl0cvyq 102 34 ) ) -RRB- cord-004751-4vl0cvyq 102 35 . . . cord-004751-4vl0cvyq 103 1 It -PRON- PRP cord-004751-4vl0cvyq 103 2 is be VBZ cord-004751-4vl0cvyq 103 3 now now RB cord-004751-4vl0cvyq 103 4 necessary necessary JJ cord-004751-4vl0cvyq 103 5 to to TO cord-004751-4vl0cvyq 103 6 determine determine VB cord-004751-4vl0cvyq 103 7 whether whether IN cord-004751-4vl0cvyq 103 8 these these DT cord-004751-4vl0cvyq 103 9 strains strain NNS cord-004751-4vl0cvyq 103 10 are be VBP cord-004751-4vl0cvyq 103 11 a]so a]so IN cord-004751-4vl0cvyq 103 12 avirulent avirulent NN cord-004751-4vl0cvyq 103 13 in in IN cord-004751-4vl0cvyq 103 14 our -PRON- PRP$ cord-004751-4vl0cvyq 103 15 tests test NNS cord-004751-4vl0cvyq 103 16 . . . cord-004751-4vl0cvyq 104 1 Likewise likewise RB cord-004751-4vl0cvyq 104 2 recombinants recombinant NNS cord-004751-4vl0cvyq 104 3 made make VBN cord-004751-4vl0cvyq 104 4 with with IN cord-004751-4vl0cvyq 104 5 other other JJ cord-004751-4vl0cvyq 104 6 attenuated attenuated JJ cord-004751-4vl0cvyq 104 7 strains strain NNS cord-004751-4vl0cvyq 104 8 should should MD cord-004751-4vl0cvyq 104 9 be be VB cord-004751-4vl0cvyq 104 10 tested test VBN cord-004751-4vl0cvyq 104 11 to to TO cord-004751-4vl0cvyq 104 12 establish establish VB cord-004751-4vl0cvyq 104 13 the the DT cord-004751-4vl0cvyq 104 14 validity validity NN cord-004751-4vl0cvyq 104 15 of of IN cord-004751-4vl0cvyq 104 16 the the DT cord-004751-4vl0cvyq 104 17 test test NN cord-004751-4vl0cvyq 104 18 . . . cord-004751-4vl0cvyq 105 1 If if IN cord-004751-4vl0cvyq 105 2 it -PRON- PRP cord-004751-4vl0cvyq 105 3 can can MD cord-004751-4vl0cvyq 105 4 be be VB cord-004751-4vl0cvyq 105 5 established establish VBN cord-004751-4vl0cvyq 105 6 it -PRON- PRP cord-004751-4vl0cvyq 105 7 would would MD cord-004751-4vl0cvyq 105 8 suggest suggest VB cord-004751-4vl0cvyq 105 9 that that IN cord-004751-4vl0cvyq 105 10 the the DT cord-004751-4vl0cvyq 105 11 only only JJ cord-004751-4vl0cvyq 105 12 really really RB cord-004751-4vl0cvyq 105 13 important important JJ cord-004751-4vl0cvyq 105 14 factor factor NN cord-004751-4vl0cvyq 105 15 in in IN cord-004751-4vl0cvyq 105 16 virulence virulence NN cord-004751-4vl0cvyq 105 17 for for IN cord-004751-4vl0cvyq 105 18 man man NN cord-004751-4vl0cvyq 105 19 is be VBZ cord-004751-4vl0cvyq 105 20 whether whether IN cord-004751-4vl0cvyq 105 21 the the DT cord-004751-4vl0cvyq 105 22 virus virus NN cord-004751-4vl0cvyq 105 23 multiplies multiply VBZ cord-004751-4vl0cvyq 105 24 in in IN cord-004751-4vl0cvyq 105 25 tracheal tracheal JJ cord-004751-4vl0cvyq 105 26 cells cell NNS cord-004751-4vl0cvyq 105 27 . . . cord-004751-4vl0cvyq 106 1 Attenuation attenuation NN cord-004751-4vl0cvyq 106 2 of of IN cord-004751-4vl0cvyq 106 3 human human JJ cord-004751-4vl0cvyq 106 4 influenza influenza NN cord-004751-4vl0cvyq 106 5 A a DT cord-004751-4vl0cvyq 106 6 viruses virus NNS cord-004751-4vl0cvyq 107 1 Recombinant recombinant JJ cord-004751-4vl0cvyq 108 1 influenza influenza NN cord-004751-4vl0cvyq 108 2 A a DT cord-004751-4vl0cvyq 108 3 viruses virus NNS cord-004751-4vl0cvyq 108 4 as as IN cord-004751-4vl0cvyq 108 5 live live JJ cord-004751-4vl0cvyq 108 6 vaccines vaccine NNS cord-004751-4vl0cvyq 108 7 for for IN cord-004751-4vl0cvyq 108 8 man man NN cord-004751-4vl0cvyq 108 9 Large large JJ cord-004751-4vl0cvyq 108 10 quantity quantity NN cord-004751-4vl0cvyq 108 11 production production NN cord-004751-4vl0cvyq 108 12 of of IN cord-004751-4vl0cvyq 108 13 chicken chicken NN cord-004751-4vl0cvyq 108 14 embryo embryo NN cord-004751-4vl0cvyq 108 15 trachea trachea NN cord-004751-4vl0cvyq 108 16 organ organ NN cord-004751-4vl0cvyq 108 17 cultures culture NNS cord-004751-4vl0cvyq 108 18 for for IN cord-004751-4vl0cvyq 108 19 use use NN cord-004751-4vl0cvyq 108 20 of of IN cord-004751-4vl0cvyq 108 21 virus virus NN cord-004751-4vl0cvyq 108 22 and and CC cord-004751-4vl0cvyq 108 23 mycoplasma mycoplasma NN cord-004751-4vl0cvyq 108 24 studies study NNS cord-004751-4vl0cvyq 108 25 Test test NN cord-004751-4vl0cvyq 108 26 tube tube NN cord-004751-4vl0cvyq 108 27 organ organ NN cord-004751-4vl0cvyq 108 28 cultures culture NNS cord-004751-4vl0cvyq 108 29 of of IN cord-004751-4vl0cvyq 108 30 ciliated ciliated JJ cord-004751-4vl0cvyq 108 31 epithelium epithelium NN cord-004751-4vl0cvyq 108 32 for for IN cord-004751-4vl0cvyq 108 33 the the DT cord-004751-4vl0cvyq 108 34 isolation isolation NN cord-004751-4vl0cvyq 108 35 of of IN cord-004751-4vl0cvyq 108 36 respiratory respiratory JJ cord-004751-4vl0cvyq 108 37 viruses virus NNS cord-004751-4vl0cvyq 108 38 Future future JJ cord-004751-4vl0cvyq 108 39 influenza influenza NN cord-004751-4vl0cvyq 108 40 vaccines vaccine NNS cord-004751-4vl0cvyq 108 41 and and CC cord-004751-4vl0cvyq 108 42 the the DT cord-004751-4vl0cvyq 108 43 use use NN cord-004751-4vl0cvyq 108 44 of of IN cord-004751-4vl0cvyq 108 45 genetic genetic JJ cord-004751-4vl0cvyq 108 46 recombinants recombinant NNS cord-004751-4vl0cvyq 109 1 The the DT cord-004751-4vl0cvyq 109 2 growth growth NN cord-004751-4vl0cvyq 109 3 and and CC cord-004751-4vl0cvyq 109 4 maintenance maintenance NN cord-004751-4vl0cvyq 109 5 of of IN cord-004751-4vl0cvyq 109 6 tissue tissue NN cord-004751-4vl0cvyq 109 7 - - HYPH cord-004751-4vl0cvyq 109 8 cell cell NN cord-004751-4vl0cvyq 109 9 cultures culture NNS cord-004751-4vl0cvyq 109 10 in in IN cord-004751-4vl0cvyq 109 11 free free JJ cord-004751-4vl0cvyq 109 12 gas gas NN cord-004751-4vl0cvyq 109 13 exchange exchange NN cord-004751-4vl0cvyq 109 14 with with IN cord-004751-4vl0cvyq 109 15 the the DT cord-004751-4vl0cvyq 109 16 atmosphere atmosphere NN cord-004751-4vl0cvyq 109 17 SCHILD SCHILD NNP cord-004751-4vl0cvyq 109 18 : : : cord-004751-4vl0cvyq 109 19 Segregation segregation NN cord-004751-4vl0cvyq 109 20 of of IN cord-004751-4vl0cvyq 109 21 antigenic antigenic JJ cord-004751-4vl0cvyq 109 22 and and CC cord-004751-4vl0cvyq 109 23 biological biological JJ cord-004751-4vl0cvyq 109 24 characteristics characteristic NNS cord-004751-4vl0cvyq 109 25 during during IN cord-004751-4vl0cvyq 109 26 influenza influenza NN cord-004751-4vl0cvyq 109 27 virus virus NN cord-004751-4vl0cvyq 109 28 recombination recombination NN cord-004751-4vl0cvyq 109 29 TYRRELL TYRRELL NNP cord-004751-4vl0cvyq 109 30 : : : cord-004751-4vl0cvyq 110 1 Detection detection NN cord-004751-4vl0cvyq 110 2 of of IN cord-004751-4vl0cvyq 110 3 attenuation attenuation NN cord-004751-4vl0cvyq 110 4 of of IN cord-004751-4vl0cvyq 110 5 recombinant recombinant JJ cord-004751-4vl0cvyq 110 6 influenza influenza NN cord-004751-4vl0cvyq 110 7 viruses virus NNS cord-004751-4vl0cvyq 110 8 in in IN cord-004751-4vl0cvyq 110 9 vitro vitro FW cord-004751-4vl0cvyq 110 10 MUFSO MUFSO NNP cord-004751-4vl0cvyq 111 1 ~r ~r NFP cord-004751-4vl0cvyq 111 2 Viral viral JJ cord-004751-4vl0cvyq 111 3 and and CC cord-004751-4vl0cvyq 111 4 mycoplasmal mycoplasmal JJ cord-004751-4vl0cvyq 111 5 infections infection NNS cord-004751-4vl0cvyq 111 6 in in IN cord-004751-4vl0cvyq 111 7 minor minor JJ cord-004751-4vl0cvyq 111 8 respiratory respiratory JJ cord-004751-4vl0cvyq 111 9 illnesses illness NNS cord-004751-4vl0cvyq 111 10 and and CC cord-004751-4vl0cvyq 111 11 non non JJ cord-004751-4vl0cvyq 111 12 - - JJ cord-004751-4vl0cvyq 111 13 streptococcal streptococcal JJ cord-004751-4vl0cvyq 111 14 pharyngitis pharyngitis NN cord-004751-4vl0cvyq 111 15 . . . cord-004751-4vl0cvyq 112 1 A a DT cord-004751-4vl0cvyq 112 2 search search NN cord-004751-4vl0cvyq 112 3 for for IN cord-004751-4vl0cvyq 112 4 coronaviruses coronaviruse NNS cord-004751-4vl0cvyq 112 5 using use VBG cord-004751-4vl0cvyq 112 6 foetal foetal JJ cord-004751-4vl0cvyq 112 7 trachea trachea NN cord-004751-4vl0cvyq 112 8 organ organ NN cord-004751-4vl0cvyq 112 9 cultures culture NNS cord-004751-4vl0cvyq 112 10 Studies Studies NNPS cord-004751-4vl0cvyq 112 11 with with IN cord-004751-4vl0cvyq 112 12 inactivated inactivate VBN cord-004751-4vl0cvyq 112 13 influenza influenza NN cord-004751-4vl0cvyq 112 14 vaccines vaccine NNS cord-004751-4vl0cvyq 112 15 purified purify VBN cord-004751-4vl0cvyq 112 16 by by IN cord-004751-4vl0cvyq 112 17 zonal zonal JJ cord-004751-4vl0cvyq 112 18 ultracentrifugation ultracentrifugation NN