id	sid	tid	token	lemma	pos
cord-341968-uc8i9h0m	1	1	key	key	NN
cord-341968-uc8i9h0m	1	2	:	:	:
cord-341968-uc8i9h0m	1	3	cord-341968-uc8i9h0	cord-341968-uc8i9h0	NNP
cord-341968-uc8i9h0m	1	4	m	m	CD
cord-341968-uc8i9h0m	1	5	authors	author	NNS
cord-341968-uc8i9h0m	1	6	:	:	:
cord-341968-uc8i9h0m	1	7	Izaguirre	Izaguirre	NNP
cord-341968-uc8i9h0m	1	8	,	,	,
cord-341968-uc8i9h0m	1	9	Gonzalo	Gonzalo	NNP
cord-341968-uc8i9h0m	1	10	title	title	NN
cord-341968-uc8i9h0m	1	11	:	:	:
cord-341968-uc8i9h0m	1	12	The	the	DT
cord-341968-uc8i9h0m	1	13	Proteolytic	Proteolytic	NNP
cord-341968-uc8i9h0m	1	14	Regulation	Regulation	NNP
cord-341968-uc8i9h0m	1	15	of	of	IN
cord-341968-uc8i9h0m	1	16	Virus	Virus	NNP
cord-341968-uc8i9h0m	1	17	Cell	Cell	NNP
cord-341968-uc8i9h0m	1	18	Entry	Entry	NNP
cord-341968-uc8i9h0m	1	19	by	by	IN
cord-341968-uc8i9h0m	1	20	Furin	Furin	NNP
cord-341968-uc8i9h0m	1	21	and	and	CC
cord-341968-uc8i9h0m	1	22	Other	Other	NNP
cord-341968-uc8i9h0m	1	23	Proprotein	Proprotein	NNP
cord-341968-uc8i9h0m	1	24	Convertases	Convertases	NNP
cord-341968-uc8i9h0m	2	1	date	date	NN
cord-341968-uc8i9h0m	2	2	:	:	:
cord-341968-uc8i9h0m	2	3	2019	2019	CD
cord-341968-uc8i9h0m	2	4	-	-	HYPH
cord-341968-uc8i9h0m	2	5	09	09	CD
cord-341968-uc8i9h0m	2	6	-	-	HYPH
cord-341968-uc8i9h0m	2	7	09	09	CD
cord-341968-uc8i9h0m	2	8	journal	journal	NN
cord-341968-uc8i9h0m	2	9	:	:	:
cord-341968-uc8i9h0m	3	1	Viruses	virus	NNS
cord-341968-uc8i9h0m	3	2	DOI	DOI	NNP
cord-341968-uc8i9h0m	3	3	:	:	:
cord-341968-uc8i9h0m	4	1	10.3390	10.3390	CD
cord-341968-uc8i9h0m	4	2	/	/	SYM
cord-341968-uc8i9h0m	4	3	v11090837	v11090837	NNP
cord-341968-uc8i9h0m	4	4	sha	sha	NNP
cord-341968-uc8i9h0m	4	5	:	:	:
cord-341968-uc8i9h0m	5	1	f7453f0f1f131d4f8603bf708f8c08d9b9e8806f	f7453f0f1f131d4f8603bf708f8c08d9b9e8806f	NNP
cord-341968-uc8i9h0m	5	2	doc_id	doc_id	CD
cord-341968-uc8i9h0m	5	3	:	:	:
cord-341968-uc8i9h0m	5	4	341968	341968	CD
cord-341968-uc8i9h0m	5	5	cord_uid	cord_uid	NNS
cord-341968-uc8i9h0m	5	6	:	:	:
cord-341968-uc8i9h0m	6	1	uc8i9h0	uc8i9h0	NN
cord-341968-uc8i9h0m	6	2	m	m	NNP
cord-341968-uc8i9h0m	6	3	A	a	DT
cord-341968-uc8i9h0m	6	4	wide	wide	JJ
cord-341968-uc8i9h0m	6	5	variety	variety	NN
cord-341968-uc8i9h0m	6	6	of	of	IN
cord-341968-uc8i9h0m	6	7	viruses	virus	NNS
cord-341968-uc8i9h0m	6	8	exploit	exploit	VBP
cord-341968-uc8i9h0m	6	9	furin	furin	NN
cord-341968-uc8i9h0m	6	10	and	and	CC
cord-341968-uc8i9h0m	6	11	other	other	JJ
cord-341968-uc8i9h0m	6	12	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	6	13	convertases	convertases	NNP
cord-341968-uc8i9h0m	6	14	(	(	-LRB-
cord-341968-uc8i9h0m	6	15	PCs	pc	NNS
cord-341968-uc8i9h0m	6	16	)	)	-RRB-
cord-341968-uc8i9h0m	6	17	of	of	IN
cord-341968-uc8i9h0m	6	18	the	the	DT
cord-341968-uc8i9h0m	6	19	constitutive	constitutive	JJ
cord-341968-uc8i9h0m	6	20	protein	protein	NN
cord-341968-uc8i9h0m	6	21	secretion	secretion	NN
cord-341968-uc8i9h0m	6	22	pathway	pathway	NN
cord-341968-uc8i9h0m	6	23	in	in	IN
cord-341968-uc8i9h0m	6	24	order	order	NN
cord-341968-uc8i9h0m	6	25	to	to	TO
cord-341968-uc8i9h0m	6	26	regulate	regulate	VB
cord-341968-uc8i9h0m	6	27	their	-PRON-	PRP$
cord-341968-uc8i9h0m	6	28	cell	cell	NN
cord-341968-uc8i9h0m	6	29	entry	entry	NN
cord-341968-uc8i9h0m	6	30	mechanism	mechanism	NN
cord-341968-uc8i9h0m	6	31	and	and	CC
cord-341968-uc8i9h0m	6	32	infectivity	infectivity	NN
cord-341968-uc8i9h0m	6	33	.	.	.
cord-341968-uc8i9h0m	7	1	Surface	surface	NN
cord-341968-uc8i9h0m	7	2	proteins	protein	NNS
cord-341968-uc8i9h0m	7	3	of	of	IN
cord-341968-uc8i9h0m	7	4	enveloped	envelop	VBN
cord-341968-uc8i9h0m	7	5	,	,	,
cord-341968-uc8i9h0m	7	6	as	as	RB
cord-341968-uc8i9h0m	7	7	well	well	RB
cord-341968-uc8i9h0m	7	8	as	as	IN
cord-341968-uc8i9h0m	7	9	non	non	JJ
cord-341968-uc8i9h0m	7	10	-	-	JJ
cord-341968-uc8i9h0m	7	11	enveloped	enveloped	JJ
cord-341968-uc8i9h0m	7	12	,	,	,
cord-341968-uc8i9h0m	7	13	viruses	virus	NNS
cord-341968-uc8i9h0m	7	14	become	become	VBN
cord-341968-uc8i9h0m	7	15	processed	process	VBN
cord-341968-uc8i9h0m	7	16	by	by	IN
cord-341968-uc8i9h0m	7	17	these	these	DT
cord-341968-uc8i9h0m	7	18	proteases	protease	NNS
cord-341968-uc8i9h0m	7	19	intracellularly	intracellularly	RB
cord-341968-uc8i9h0m	7	20	during	during	IN
cord-341968-uc8i9h0m	7	21	morphogenesis	morphogenesis	NN
cord-341968-uc8i9h0m	7	22	or	or	CC
cord-341968-uc8i9h0m	7	23	extracellularly	extracellularly	RB
cord-341968-uc8i9h0m	7	24	after	after	IN
cord-341968-uc8i9h0m	7	25	egress	egress	NN
cord-341968-uc8i9h0m	7	26	and	and	CC
cord-341968-uc8i9h0m	7	27	during	during	IN
cord-341968-uc8i9h0m	7	28	entry	entry	NN
cord-341968-uc8i9h0m	7	29	in	in	IN
cord-341968-uc8i9h0m	7	30	order	order	NN
cord-341968-uc8i9h0m	7	31	to	to	TO
cord-341968-uc8i9h0m	7	32	produce	produce	VB
cord-341968-uc8i9h0m	7	33	mature	mature	JJ
cord-341968-uc8i9h0m	7	34	virions	virion	NNS
cord-341968-uc8i9h0m	7	35	activated	activate	VBN
cord-341968-uc8i9h0m	7	36	for	for	IN
cord-341968-uc8i9h0m	7	37	infection	infection	NN
cord-341968-uc8i9h0m	7	38	.	.	.
cord-341968-uc8i9h0m	8	1	Although	although	IN
cord-341968-uc8i9h0m	8	2	viruses	virus	NNS
cord-341968-uc8i9h0m	8	3	also	also	RB
cord-341968-uc8i9h0m	8	4	take	take	VBP
cord-341968-uc8i9h0m	8	5	advantage	advantage	NN
cord-341968-uc8i9h0m	8	6	of	of	IN
cord-341968-uc8i9h0m	8	7	other	other	JJ
cord-341968-uc8i9h0m	8	8	proteases	protease	NNS
cord-341968-uc8i9h0m	8	9	,	,	,
cord-341968-uc8i9h0m	8	10	it	-PRON-	PRP
cord-341968-uc8i9h0m	8	11	is	be	VBZ
cord-341968-uc8i9h0m	8	12	when	when	WRB
cord-341968-uc8i9h0m	8	13	some	some	DT
cord-341968-uc8i9h0m	8	14	viruses	virus	NNS
cord-341968-uc8i9h0m	8	15	become	become	VBP
cord-341968-uc8i9h0m	8	16	reactive	reactive	JJ
cord-341968-uc8i9h0m	8	17	with	with	IN
cord-341968-uc8i9h0m	8	18	PCs	pc	NNS
cord-341968-uc8i9h0m	8	19	that	that	IN
cord-341968-uc8i9h0m	8	20	they	-PRON-	PRP
cord-341968-uc8i9h0m	8	21	may	may	MD
cord-341968-uc8i9h0m	8	22	develop	develop	VB
cord-341968-uc8i9h0m	8	23	high	high	JJ
cord-341968-uc8i9h0m	8	24	pathogenicity	pathogenicity	NN
cord-341968-uc8i9h0m	8	25	.	.	.
cord-341968-uc8i9h0m	9	1	Besides	besides	IN
cord-341968-uc8i9h0m	9	2	reacting	react	VBG
cord-341968-uc8i9h0m	9	3	with	with	IN
cord-341968-uc8i9h0m	9	4	furin	furin	NN
cord-341968-uc8i9h0m	9	5	,	,	,
cord-341968-uc8i9h0m	9	6	some	some	DT
cord-341968-uc8i9h0m	9	7	viruses	virus	NNS
cord-341968-uc8i9h0m	9	8	may	may	MD
cord-341968-uc8i9h0m	9	9	also	also	RB
cord-341968-uc8i9h0m	9	10	react	react	VB
cord-341968-uc8i9h0m	9	11	with	with	IN
cord-341968-uc8i9h0m	9	12	the	the	DT
cord-341968-uc8i9h0m	9	13	PCs	pc	NNS
cord-341968-uc8i9h0m	9	14	of	of	IN
cord-341968-uc8i9h0m	9	15	the	the	DT
cord-341968-uc8i9h0m	9	16	other	other	JJ
cord-341968-uc8i9h0m	9	17	specificity	specificity	NN
cord-341968-uc8i9h0m	9	18	group	group	NN
cord-341968-uc8i9h0m	9	19	constituted	constitute	VBN
cord-341968-uc8i9h0m	9	20	by	by	IN
cord-341968-uc8i9h0m	9	21	PC4	PC4	NNP
cord-341968-uc8i9h0m	9	22	/	/	SYM
cord-341968-uc8i9h0m	9	23	PC5	PC5	NNP
cord-341968-uc8i9h0m	9	24	/	/	SYM
cord-341968-uc8i9h0m	9	25	PACE4	PACE4	NNP
cord-341968-uc8i9h0m	9	26	/	/	SYM
cord-341968-uc8i9h0m	9	27	PC7	PC7	NNP
cord-341968-uc8i9h0m	9	28	.	.	.
cord-341968-uc8i9h0m	10	1	The	the	DT
cord-341968-uc8i9h0m	10	2	targeting	targeting	NN
cord-341968-uc8i9h0m	10	3	of	of	IN
cord-341968-uc8i9h0m	10	4	PCs	pc	NNS
cord-341968-uc8i9h0m	10	5	for	for	IN
cord-341968-uc8i9h0m	10	6	inhibition	inhibition	NN
cord-341968-uc8i9h0m	10	7	may	may	MD
cord-341968-uc8i9h0m	10	8	result	result	VB
cord-341968-uc8i9h0m	10	9	in	in	IN
cord-341968-uc8i9h0m	10	10	a	a	DT
cord-341968-uc8i9h0m	10	11	useful	useful	JJ
cord-341968-uc8i9h0m	10	12	strategy	strategy	NN
cord-341968-uc8i9h0m	10	13	to	to	TO
cord-341968-uc8i9h0m	10	14	treat	treat	VB
cord-341968-uc8i9h0m	10	15	infections	infection	NNS
cord-341968-uc8i9h0m	10	16	with	with	IN
cord-341968-uc8i9h0m	10	17	some	some	DT
cord-341968-uc8i9h0m	10	18	highly	highly	RB
cord-341968-uc8i9h0m	10	19	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	10	20	viruses	virus	NNS
cord-341968-uc8i9h0m	10	21	.	.	.
cord-341968-uc8i9h0m	11	1	A	a	DT
cord-341968-uc8i9h0m	11	2	wide	wide	JJ
cord-341968-uc8i9h0m	11	3	variety	variety	NN
cord-341968-uc8i9h0m	11	4	of	of	IN
cord-341968-uc8i9h0m	11	5	PC	pc	NN
cord-341968-uc8i9h0m	11	6	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	11	7	have	have	VBP
cord-341968-uc8i9h0m	11	8	been	be	VBN
cord-341968-uc8i9h0m	11	9	developed	develop	VBN
cord-341968-uc8i9h0m	11	10	and	and	CC
cord-341968-uc8i9h0m	11	11	tested	test	VBN
cord-341968-uc8i9h0m	11	12	for	for	IN
cord-341968-uc8i9h0m	11	13	their	-PRON-	PRP$
cord-341968-uc8i9h0m	11	14	antiviral	antiviral	JJ
cord-341968-uc8i9h0m	11	15	activity	activity	NN
cord-341968-uc8i9h0m	11	16	in	in	IN
cord-341968-uc8i9h0m	11	17	cell	cell	NN
cord-341968-uc8i9h0m	11	18	-	-	HYPH
cord-341968-uc8i9h0m	11	19	based	base	VBN
cord-341968-uc8i9h0m	11	20	assays	assay	NNS
cord-341968-uc8i9h0m	11	21	.	.	.
cord-341968-uc8i9h0m	12	1	The	the	DT
cord-341968-uc8i9h0m	12	2	regulation	regulation	NN
cord-341968-uc8i9h0m	12	3	of	of	IN
cord-341968-uc8i9h0m	12	4	viral	viral	JJ
cord-341968-uc8i9h0m	12	5	cell	cell	NN
cord-341968-uc8i9h0m	12	6	entry	entry	NN
cord-341968-uc8i9h0m	12	7	by	by	IN
cord-341968-uc8i9h0m	12	8	proteases	protease	NNS
cord-341968-uc8i9h0m	12	9	is	be	VBZ
cord-341968-uc8i9h0m	12	10	a	a	DT
cord-341968-uc8i9h0m	12	11	control	control	NN
cord-341968-uc8i9h0m	12	12	mechanism	mechanism	NN
cord-341968-uc8i9h0m	12	13	common	common	JJ
cord-341968-uc8i9h0m	12	14	among	among	IN
cord-341968-uc8i9h0m	12	15	viruses	virus	NNS
cord-341968-uc8i9h0m	12	16	(	(	-LRB-
cord-341968-uc8i9h0m	12	17	Table	table	NN
cord-341968-uc8i9h0m	12	18	1	1	CD
cord-341968-uc8i9h0m	12	19	)	)	-RRB-
cord-341968-uc8i9h0m	12	20	.	.	.
cord-341968-uc8i9h0m	13	1	The	the	DT
cord-341968-uc8i9h0m	13	2	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	13	3	processing	processing	NN
cord-341968-uc8i9h0m	13	4	of	of	IN
cord-341968-uc8i9h0m	13	5	viral	viral	JJ
cord-341968-uc8i9h0m	13	6	proteins	protein	NNS
cord-341968-uc8i9h0m	13	7	is	be	VBZ
cord-341968-uc8i9h0m	13	8	often	often	RB
cord-341968-uc8i9h0m	13	9	required	require	VBN
cord-341968-uc8i9h0m	13	10	for	for	IN
cord-341968-uc8i9h0m	13	11	virus	virus	NN
cord-341968-uc8i9h0m	13	12	maturation	maturation	NN
cord-341968-uc8i9h0m	13	13	and	and	CC
cord-341968-uc8i9h0m	13	14	infectivity	infectivity	NN
cord-341968-uc8i9h0m	13	15	.	.	.
cord-341968-uc8i9h0m	14	1	A	a	DT
cord-341968-uc8i9h0m	14	2	critical	critical	JJ
cord-341968-uc8i9h0m	14	3	group	group	NN
cord-341968-uc8i9h0m	14	4	of	of	IN
cord-341968-uc8i9h0m	14	5	host	host	NN
cord-341968-uc8i9h0m	14	6	-	-	HYPH
cord-341968-uc8i9h0m	14	7	cell	cell	NN
cord-341968-uc8i9h0m	14	8	proteases	protease	NNS
cord-341968-uc8i9h0m	14	9	exploited	exploit	VBN
cord-341968-uc8i9h0m	14	10	by	by	IN
cord-341968-uc8i9h0m	14	11	a	a	DT
cord-341968-uc8i9h0m	14	12	variety	variety	NN
cord-341968-uc8i9h0m	14	13	of	of	IN
cord-341968-uc8i9h0m	14	14	viruses	virus	NNS
cord-341968-uc8i9h0m	14	15	is	be	VBZ
cord-341968-uc8i9h0m	14	16	the	the	DT
cord-341968-uc8i9h0m	14	17	family	family	NN
cord-341968-uc8i9h0m	14	18	of	of	IN
cord-341968-uc8i9h0m	14	19	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	14	20	convertases	convertases	NNP
cord-341968-uc8i9h0m	14	21	(	(	-LRB-
cord-341968-uc8i9h0m	14	22	PCs	pc	NNS
cord-341968-uc8i9h0m	14	23	)	)	-RRB-
cord-341968-uc8i9h0m	14	24	,	,	,
cord-341968-uc8i9h0m	14	25	which	which	WDT
cord-341968-uc8i9h0m	14	26	includes	include	VBZ
cord-341968-uc8i9h0m	14	27	furin	furin	NN
cord-341968-uc8i9h0m	14	28	,	,	,
cord-341968-uc8i9h0m	14	29	PC4	PC4	NNP
cord-341968-uc8i9h0m	14	30	,	,	,
cord-341968-uc8i9h0m	14	31	PC5	PC5	NNP
cord-341968-uc8i9h0m	14	32	,	,	,
cord-341968-uc8i9h0m	14	33	PACE4	pace4	CD
cord-341968-uc8i9h0m	14	34	,	,	,
cord-341968-uc8i9h0m	14	35	and	and	CC
cord-341968-uc8i9h0m	14	36	PC7	PC7	NNS
cord-341968-uc8i9h0m	14	37	[	[	-LRB-
cord-341968-uc8i9h0m	14	38	1	1	CD
cord-341968-uc8i9h0m	14	39	,	,	,
cord-341968-uc8i9h0m	14	40	2	2	CD
cord-341968-uc8i9h0m	14	41	]	]	-RRB-
cord-341968-uc8i9h0m	14	42	.	.	.
cord-341968-uc8i9h0m	15	1	Although	although	IN
cord-341968-uc8i9h0m	15	2	other	other	JJ
cord-341968-uc8i9h0m	15	3	types	type	NNS
cord-341968-uc8i9h0m	15	4	of	of	IN
cord-341968-uc8i9h0m	15	5	proteases	protease	NNS
cord-341968-uc8i9h0m	15	6	besides	besides	IN
cord-341968-uc8i9h0m	15	7	PCs	pc	NNS
cord-341968-uc8i9h0m	15	8	can	can	MD
cord-341968-uc8i9h0m	15	9	also	also	RB
cord-341968-uc8i9h0m	15	10	perform	perform	VB
cord-341968-uc8i9h0m	15	11	the	the	DT
cord-341968-uc8i9h0m	15	12	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	15	13	maturation	maturation	NN
cord-341968-uc8i9h0m	15	14	of	of	IN
cord-341968-uc8i9h0m	15	15	viruses	virus	NNS
cord-341968-uc8i9h0m	15	16	,	,	,
cord-341968-uc8i9h0m	15	17	it	-PRON-	PRP
cord-341968-uc8i9h0m	15	18	has	have	VBZ
cord-341968-uc8i9h0m	15	19	been	be	VBN
cord-341968-uc8i9h0m	15	20	observed	observe	VBN
cord-341968-uc8i9h0m	15	21	that	that	IN
cord-341968-uc8i9h0m	15	22	when	when	WRB
cord-341968-uc8i9h0m	15	23	PCs	pc	NNS
cord-341968-uc8i9h0m	15	24	process	process	VBP
cord-341968-uc8i9h0m	15	25	viral	viral	JJ
cord-341968-uc8i9h0m	15	26	proteins	protein	NNS
cord-341968-uc8i9h0m	15	27	,	,	,
cord-341968-uc8i9h0m	15	28	some	some	DT
cord-341968-uc8i9h0m	15	29	viruses	virus	NNS
cord-341968-uc8i9h0m	15	30	become	become	VBP
cord-341968-uc8i9h0m	15	31	comparatively	comparatively	RB
cord-341968-uc8i9h0m	15	32	more	more	RBR
cord-341968-uc8i9h0m	15	33	infective	infective	JJ
cord-341968-uc8i9h0m	15	34	and	and	CC
cord-341968-uc8i9h0m	15	35	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	15	36	.	.	.
cord-341968-uc8i9h0m	16	1	Most	Most	JJS
cord-341968-uc8i9h0m	16	2	of	of	IN
cord-341968-uc8i9h0m	16	3	the	the	DT
cord-341968-uc8i9h0m	16	4	research	research	NN
cord-341968-uc8i9h0m	16	5	done	do	VBN
cord-341968-uc8i9h0m	16	6	on	on	IN
cord-341968-uc8i9h0m	16	7	the	the	DT
cord-341968-uc8i9h0m	16	8	maturation	maturation	NN
cord-341968-uc8i9h0m	16	9	of	of	IN
cord-341968-uc8i9h0m	16	10	viruses	virus	NNS
cord-341968-uc8i9h0m	16	11	by	by	IN
cord-341968-uc8i9h0m	16	12	PCs	pc	NNS
cord-341968-uc8i9h0m	16	13	has	have	VBZ
cord-341968-uc8i9h0m	16	14	focused	focus	VBN
cord-341968-uc8i9h0m	16	15	on	on	IN
cord-341968-uc8i9h0m	16	16	furin	furin	NN
cord-341968-uc8i9h0m	16	17	.	.	.
cord-341968-uc8i9h0m	17	1	However	however	RB
cord-341968-uc8i9h0m	17	2	,	,	,
cord-341968-uc8i9h0m	17	3	there	there	EX
cord-341968-uc8i9h0m	17	4	is	be	VBZ
cord-341968-uc8i9h0m	17	5	evidence	evidence	NN
cord-341968-uc8i9h0m	17	6	of	of	IN
cord-341968-uc8i9h0m	17	7	the	the	DT
cord-341968-uc8i9h0m	17	8	involvement	involvement	NN
cord-341968-uc8i9h0m	17	9	of	of	IN
cord-341968-uc8i9h0m	17	10	other	other	JJ
cord-341968-uc8i9h0m	17	11	PCs	pc	NNS
cord-341968-uc8i9h0m	17	12	in	in	IN
cord-341968-uc8i9h0m	17	13	the	the	DT
cord-341968-uc8i9h0m	17	14	regulation	regulation	NN
cord-341968-uc8i9h0m	17	15	of	of	IN
cord-341968-uc8i9h0m	17	16	virus	virus	NN
cord-341968-uc8i9h0m	17	17	maturation	maturation	NN
cord-341968-uc8i9h0m	17	18	[	[	-LRB-
cord-341968-uc8i9h0m	17	19	3	3	CD
cord-341968-uc8i9h0m	17	20	]	]	-RRB-
cord-341968-uc8i9h0m	17	21	.	.	.
cord-341968-uc8i9h0m	18	1	The	the	DT
cord-341968-uc8i9h0m	18	2	scattered	scatter	VBN
cord-341968-uc8i9h0m	18	3	information	information	NN
cord-341968-uc8i9h0m	18	4	about	about	IN
cord-341968-uc8i9h0m	18	5	the	the	DT
cord-341968-uc8i9h0m	18	6	role	role	NN
cord-341968-uc8i9h0m	18	7	of	of	IN
cord-341968-uc8i9h0m	18	8	PCs	pc	NNS
cord-341968-uc8i9h0m	18	9	in	in	IN
cord-341968-uc8i9h0m	18	10	the	the	DT
cord-341968-uc8i9h0m	18	11	life	life	NN
cord-341968-uc8i9h0m	18	12	cycle	cycle	NN
cord-341968-uc8i9h0m	18	13	of	of	IN
cord-341968-uc8i9h0m	18	14	a	a	DT
cord-341968-uc8i9h0m	18	15	wide	wide	JJ
cord-341968-uc8i9h0m	18	16	variety	variety	NN
cord-341968-uc8i9h0m	18	17	of	of	IN
cord-341968-uc8i9h0m	18	18	viruses	virus	NNS
cord-341968-uc8i9h0m	18	19	[	[	-LRB-
cord-341968-uc8i9h0m	18	20	4	4	CD
cord-341968-uc8i9h0m	18	21	,	,	,
cord-341968-uc8i9h0m	18	22	5	5	CD
cord-341968-uc8i9h0m	18	23	]	]	-RRB-
cord-341968-uc8i9h0m	18	24	,	,	,
cord-341968-uc8i9h0m	18	25	in	in	IN
cord-341968-uc8i9h0m	18	26	addition	addition	NN
cord-341968-uc8i9h0m	18	27	to	to	IN
cord-341968-uc8i9h0m	18	28	the	the	DT
cord-341968-uc8i9h0m	18	29	new	new	JJ
cord-341968-uc8i9h0m	18	30	developments	development	NNS
cord-341968-uc8i9h0m	18	31	on	on	IN
cord-341968-uc8i9h0m	18	32	PC	pc	NN
cord-341968-uc8i9h0m	18	33	activity	activity	NN
cord-341968-uc8i9h0m	18	34	regulation	regulation	NN
cord-341968-uc8i9h0m	18	35	and	and	CC
cord-341968-uc8i9h0m	18	36	reaction	reaction	NN
cord-341968-uc8i9h0m	18	37	specificity	specificity	NN
cord-341968-uc8i9h0m	18	38	[	[	-LRB-
cord-341968-uc8i9h0m	18	39	6	6	CD
cord-341968-uc8i9h0m	18	40	]	]	-RRB-
cord-341968-uc8i9h0m	18	41	[	[	-LRB-
cord-341968-uc8i9h0m	18	42	7	7	CD
cord-341968-uc8i9h0m	18	43	]	]	-RRB-
cord-341968-uc8i9h0m	18	44	[	[	-LRB-
cord-341968-uc8i9h0m	18	45	8	8	CD
cord-341968-uc8i9h0m	18	46	]	]	-RRB-
cord-341968-uc8i9h0m	18	47	[	[	-LRB-
cord-341968-uc8i9h0m	18	48	9	9	CD
cord-341968-uc8i9h0m	18	49	]	]	-RRB-
cord-341968-uc8i9h0m	18	50	,	,	,
cord-341968-uc8i9h0m	18	51	calls	call	VBZ
cord-341968-uc8i9h0m	18	52	for	for	IN
cord-341968-uc8i9h0m	18	53	an	an	DT
cord-341968-uc8i9h0m	18	54	effort	effort	NN
cord-341968-uc8i9h0m	18	55	to	to	TO
cord-341968-uc8i9h0m	18	56	integrate	integrate	VB
cord-341968-uc8i9h0m	18	57	this	this	DT
cord-341968-uc8i9h0m	18	58	knowledge	knowledge	NN
cord-341968-uc8i9h0m	18	59	,	,	,
cord-341968-uc8i9h0m	18	60	analyze	analyze	VB
cord-341968-uc8i9h0m	18	61	the	the	DT
cord-341968-uc8i9h0m	18	62	relevance	relevance	NN
cord-341968-uc8i9h0m	18	63	of	of	IN
cord-341968-uc8i9h0m	18	64	PCs	pc	NNS
cord-341968-uc8i9h0m	18	65	in	in	IN
cord-341968-uc8i9h0m	18	66	the	the	DT
cord-341968-uc8i9h0m	18	67	pathogenicity	pathogenicity	NN
cord-341968-uc8i9h0m	18	68	of	of	IN
cord-341968-uc8i9h0m	18	69	viruses	virus	NNS
cord-341968-uc8i9h0m	18	70	,	,	,
cord-341968-uc8i9h0m	18	71	and	and	CC
cord-341968-uc8i9h0m	18	72	evaluate	evaluate	VB
cord-341968-uc8i9h0m	18	73	the	the	DT
cord-341968-uc8i9h0m	18	74	feasibility	feasibility	NN
cord-341968-uc8i9h0m	18	75	of	of	IN
cord-341968-uc8i9h0m	18	76	inhibiting	inhibit	VBG
cord-341968-uc8i9h0m	18	77	PCs	pc	NNS
cord-341968-uc8i9h0m	18	78	as	as	IN
cord-341968-uc8i9h0m	18	79	a	a	DT
cord-341968-uc8i9h0m	18	80	sound	sound	JJ
cord-341968-uc8i9h0m	18	81	strategy	strategy	NN
cord-341968-uc8i9h0m	18	82	for	for	IN
cord-341968-uc8i9h0m	18	83	antiviral	antiviral	JJ
cord-341968-uc8i9h0m	18	84	therapy	therapy	NN
cord-341968-uc8i9h0m	18	85	.	.	.
cord-341968-uc8i9h0m	19	1	This	this	DT
cord-341968-uc8i9h0m	19	2	review	review	NN
cord-341968-uc8i9h0m	19	3	will	will	MD
cord-341968-uc8i9h0m	19	4	discuss	discuss	VB
cord-341968-uc8i9h0m	19	5	the	the	DT
cord-341968-uc8i9h0m	19	6	importance	importance	NN
cord-341968-uc8i9h0m	19	7	of	of	IN
cord-341968-uc8i9h0m	19	8	differences	difference	NNS
cord-341968-uc8i9h0m	19	9	of	of	IN
cord-341968-uc8i9h0m	19	10	PC	pc	NN
cord-341968-uc8i9h0m	19	11	reactivity	reactivity	NN
cord-341968-uc8i9h0m	19	12	and	and	CC
cord-341968-uc8i9h0m	19	13	selectivity	selectivity	NN
cord-341968-uc8i9h0m	19	14	,	,	,
cord-341968-uc8i9h0m	19	15	and	and	CC
cord-341968-uc8i9h0m	19	16	the	the	DT
cord-341968-uc8i9h0m	19	17	PC	pc	NN
cord-341968-uc8i9h0m	19	18	gene	gene	NN
cord-341968-uc8i9h0m	19	19	expression	expression	NN
cord-341968-uc8i9h0m	19	20	profile	profile	NN
cord-341968-uc8i9h0m	19	21	of	of	IN
cord-341968-uc8i9h0m	19	22	infected	infected	JJ
cord-341968-uc8i9h0m	19	23	cells	cell	NNS
cord-341968-uc8i9h0m	19	24	,	,	,
cord-341968-uc8i9h0m	19	25	in	in	IN
cord-341968-uc8i9h0m	19	26	determining	determine	VBG
cord-341968-uc8i9h0m	19	27	virus	virus	NN
cord-341968-uc8i9h0m	19	28	infectivity	infectivity	NN
cord-341968-uc8i9h0m	19	29	and	and	CC
cord-341968-uc8i9h0m	19	30	tropism	tropism	NN
cord-341968-uc8i9h0m	19	31	.	.	.
cord-341968-uc8i9h0m	20	1	The	the	DT
cord-341968-uc8i9h0m	20	2	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	20	3	maturation	maturation	NN
cord-341968-uc8i9h0m	20	4	of	of	IN
cord-341968-uc8i9h0m	20	5	viruses	virus	NNS
cord-341968-uc8i9h0m	20	6	by	by	IN
cord-341968-uc8i9h0m	20	7	PCs	pc	NNS
cord-341968-uc8i9h0m	20	8	generally	generally	RB
cord-341968-uc8i9h0m	20	9	involves	involve	VBZ
cord-341968-uc8i9h0m	20	10	the	the	DT
cord-341968-uc8i9h0m	20	11	processing	processing	NN
cord-341968-uc8i9h0m	20	12	of	of	IN
cord-341968-uc8i9h0m	20	13	proteins	protein	NNS
cord-341968-uc8i9h0m	20	14	localized	localize	VBN
cord-341968-uc8i9h0m	20	15	on	on	IN
cord-341968-uc8i9h0m	20	16	the	the	DT
cord-341968-uc8i9h0m	20	17	surface	surface	NN
cord-341968-uc8i9h0m	20	18	of	of	IN
cord-341968-uc8i9h0m	20	19	viral	viral	JJ
cord-341968-uc8i9h0m	20	20	particles	particle	NNS
cord-341968-uc8i9h0m	20	21	,	,	,
cord-341968-uc8i9h0m	20	22	either	either	CC
cord-341968-uc8i9h0m	20	23	of	of	IN
cord-341968-uc8i9h0m	20	24	non	non	JJ
cord-341968-uc8i9h0m	20	25	-	-	JJ
cord-341968-uc8i9h0m	20	26	enveloped	enveloped	JJ
cord-341968-uc8i9h0m	20	27	or	or	CC
cord-341968-uc8i9h0m	20	28	enveloped	envelop	VBN
cord-341968-uc8i9h0m	20	29	viruses	virus	NNS
cord-341968-uc8i9h0m	20	30	[	[	-LRB-
cord-341968-uc8i9h0m	20	31	10	10	CD
cord-341968-uc8i9h0m	20	32	]	]	-RRB-
cord-341968-uc8i9h0m	20	33	.	.	.
cord-341968-uc8i9h0m	21	1	The	the	DT
cord-341968-uc8i9h0m	21	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	21	3	of	of	IN
cord-341968-uc8i9h0m	21	4	the	the	DT
cord-341968-uc8i9h0m	21	5	surface	surface	NN
cord-341968-uc8i9h0m	21	6	viral	viral	JJ
cord-341968-uc8i9h0m	21	7	proteins	protein	NNS
cord-341968-uc8i9h0m	21	8	mostly	mostly	RB
cord-341968-uc8i9h0m	21	9	occurs	occur	VBZ
cord-341968-uc8i9h0m	21	10	inside	inside	IN
cord-341968-uc8i9h0m	21	11	the	the	DT
cord-341968-uc8i9h0m	21	12	host	host	NN
cord-341968-uc8i9h0m	21	13	cells	cell	NNS
cord-341968-uc8i9h0m	21	14	during	during	IN
cord-341968-uc8i9h0m	21	15	virus	virus	NN
cord-341968-uc8i9h0m	21	16	morphogenesis	morphogenesis	NN
cord-341968-uc8i9h0m	21	17	and	and	CC
cord-341968-uc8i9h0m	21	18	before	before	IN
cord-341968-uc8i9h0m	21	19	egress	egress	NN
cord-341968-uc8i9h0m	21	20	,	,	,
cord-341968-uc8i9h0m	21	21	although	although	IN
cord-341968-uc8i9h0m	21	22	cleavage	cleavage	NN
cord-341968-uc8i9h0m	21	23	by	by	IN
cord-341968-uc8i9h0m	21	24	the	the	DT
cord-341968-uc8i9h0m	21	25	target	target	NN
cord-341968-uc8i9h0m	21	26	-	-	HYPH
cord-341968-uc8i9h0m	21	27	cell	cell	NN
cord-341968-uc8i9h0m	21	28	PCs	pc	NNS
cord-341968-uc8i9h0m	21	29	can	can	MD
cord-341968-uc8i9h0m	21	30	occur	occur	VB
cord-341968-uc8i9h0m	21	31	extracellularly	extracellularly	RB
cord-341968-uc8i9h0m	21	32	or	or	CC
cord-341968-uc8i9h0m	21	33	during	during	IN
cord-341968-uc8i9h0m	21	34	cell	cell	NN
cord-341968-uc8i9h0m	21	35	entry	entry	NN
cord-341968-uc8i9h0m	21	36	with	with	IN
cord-341968-uc8i9h0m	21	37	some	some	DT
cord-341968-uc8i9h0m	21	38	viruses	virus	NNS
cord-341968-uc8i9h0m	21	39	.	.	.
cord-341968-uc8i9h0m	22	1	The	the	DT
cord-341968-uc8i9h0m	22	2	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	22	3	processing	processing	NN
cord-341968-uc8i9h0m	22	4	by	by	IN
cord-341968-uc8i9h0m	22	5	PCs	pc	NNS
cord-341968-uc8i9h0m	22	6	promotes	promote	VBZ
cord-341968-uc8i9h0m	22	7	binding	binding	NN
cord-341968-uc8i9h0m	22	8	and	and	CC
cord-341968-uc8i9h0m	22	9	fusion	fusion	NN
cord-341968-uc8i9h0m	22	10	of	of	IN
cord-341968-uc8i9h0m	22	11	viral	viral	JJ
cord-341968-uc8i9h0m	22	12	particles	particle	NNS
cord-341968-uc8i9h0m	22	13	to	to	TO
cord-341968-uc8i9h0m	22	14	target	target	VB
cord-341968-uc8i9h0m	22	15	cells	cell	NNS
cord-341968-uc8i9h0m	22	16	.	.	.
cord-341968-uc8i9h0m	23	1	PCs	pc	NNS
cord-341968-uc8i9h0m	23	2	are	be	VBP
cord-341968-uc8i9h0m	23	3	eukaryotic	eukaryotic	JJ
cord-341968-uc8i9h0m	23	4	serine	serine	NN
cord-341968-uc8i9h0m	23	5	proteases	protease	NNS
cord-341968-uc8i9h0m	23	6	classified	classify	VBN
cord-341968-uc8i9h0m	23	7	in	in	IN
cord-341968-uc8i9h0m	23	8	the	the	DT
cord-341968-uc8i9h0m	23	9	MEROPS	MEROPS	NNP
cord-341968-uc8i9h0m	23	10	Peptidase	Peptidase	NNP
cord-341968-uc8i9h0m	23	11	Database	Database	NNP
cord-341968-uc8i9h0m	23	12	within	within	IN
cord-341968-uc8i9h0m	23	13	the	the	DT
cord-341968-uc8i9h0m	23	14	S8B	S8B	NNP
cord-341968-uc8i9h0m	23	15	family	family	NN
cord-341968-uc8i9h0m	23	16	.	.	.
cord-341968-uc8i9h0m	24	1	Furin	furin	NN
cord-341968-uc8i9h0m	24	2	,	,	,
cord-341968-uc8i9h0m	24	3	PC4	pc4	NN
cord-341968-uc8i9h0m	24	4	,	,	,
cord-341968-uc8i9h0m	24	5	PC5	PC5	NNP
cord-341968-uc8i9h0m	24	6	,	,	,
cord-341968-uc8i9h0m	24	7	PACE4	pace4	CD
cord-341968-uc8i9h0m	24	8	,	,	,
cord-341968-uc8i9h0m	24	9	and	and	CC
cord-341968-uc8i9h0m	24	10	PC7	PC7	NNS
cord-341968-uc8i9h0m	24	11	are	be	VBP
cord-341968-uc8i9h0m	24	12	part	part	NN
cord-341968-uc8i9h0m	24	13	of	of	IN
cord-341968-uc8i9h0m	24	14	the	the	DT
cord-341968-uc8i9h0m	24	15	Kexin	Kexin	NNP
cord-341968-uc8i9h0m	24	16	-	-	HYPH
cord-341968-uc8i9h0m	24	17	like	like	JJ
cord-341968-uc8i9h0m	24	18	subfamily	subfamily	NN
cord-341968-uc8i9h0m	24	19	of	of	IN
cord-341968-uc8i9h0m	24	20	PCs	pc	NNS
cord-341968-uc8i9h0m	24	21	and	and	CC
cord-341968-uc8i9h0m	24	22	localize	localize	VB
cord-341968-uc8i9h0m	24	23	to	to	IN
cord-341968-uc8i9h0m	24	24	the	the	DT
cord-341968-uc8i9h0m	24	25	organelles	organelle	NNS
cord-341968-uc8i9h0m	24	26	of	of	IN
cord-341968-uc8i9h0m	24	27	the	the	DT
cord-341968-uc8i9h0m	24	28	constitutive	constitutive	JJ
cord-341968-uc8i9h0m	24	29	protein	protein	NN
cord-341968-uc8i9h0m	24	30	secretion	secretion	NN
cord-341968-uc8i9h0m	24	31	pathway	pathway	NN
cord-341968-uc8i9h0m	24	32	[	[	-LRB-
cord-341968-uc8i9h0m	24	33	1	1	CD
cord-341968-uc8i9h0m	24	34	]	]	-RRB-
cord-341968-uc8i9h0m	24	35	.	.	.
cord-341968-uc8i9h0m	25	1	These	these	DT
cord-341968-uc8i9h0m	25	2	PCs	pc	NNS
cord-341968-uc8i9h0m	25	3	perform	perform	VBP
cord-341968-uc8i9h0m	25	4	the	the	DT
cord-341968-uc8i9h0m	25	5	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	25	6	post	post	JJ
cord-341968-uc8i9h0m	25	7	-	-	JJ
cord-341968-uc8i9h0m	25	8	translational	translational	JJ
cord-341968-uc8i9h0m	25	9	modification	modification	NN
cord-341968-uc8i9h0m	25	10	of	of	IN
cord-341968-uc8i9h0m	25	11	a	a	DT
cord-341968-uc8i9h0m	25	12	large	large	JJ
cord-341968-uc8i9h0m	25	13	variety	variety	NN
cord-341968-uc8i9h0m	25	14	of	of	IN
cord-341968-uc8i9h0m	25	15	peptides	peptide	NNS
cord-341968-uc8i9h0m	25	16	and	and	CC
cord-341968-uc8i9h0m	25	17	proteins	protein	NNS
cord-341968-uc8i9h0m	25	18	in	in	IN
cord-341968-uc8i9h0m	25	19	the	the	DT
cord-341968-uc8i9h0m	25	20	trans	trans	NNP
cord-341968-uc8i9h0m	25	21	-	-	NNP
cord-341968-uc8i9h0m	25	22	Golgi	Golgi	NNP
cord-341968-uc8i9h0m	25	23	network	network	NN
cord-341968-uc8i9h0m	25	24	,	,	,
cord-341968-uc8i9h0m	25	25	endosomes	endosome	NNS
cord-341968-uc8i9h0m	25	26	,	,	,
cord-341968-uc8i9h0m	25	27	and	and	CC
cord-341968-uc8i9h0m	25	28	pericellular	pericellular	JJ
cord-341968-uc8i9h0m	25	29	environment	environment	NN
cord-341968-uc8i9h0m	25	30	,	,	,
cord-341968-uc8i9h0m	25	31	and	and	CC
cord-341968-uc8i9h0m	25	32	are	be	VBP
cord-341968-uc8i9h0m	25	33	critical	critical	JJ
cord-341968-uc8i9h0m	25	34	regulators	regulator	NNS
cord-341968-uc8i9h0m	25	35	of	of	IN
cord-341968-uc8i9h0m	25	36	central	central	JJ
cord-341968-uc8i9h0m	25	37	cellular	cellular	JJ
cord-341968-uc8i9h0m	25	38	processes	process	NNS
cord-341968-uc8i9h0m	25	39	,	,	,
cord-341968-uc8i9h0m	25	40	such	such	JJ
cord-341968-uc8i9h0m	25	41	as	as	IN
cord-341968-uc8i9h0m	25	42	growth	growth	NN
cord-341968-uc8i9h0m	25	43	,	,	,
cord-341968-uc8i9h0m	25	44	proliferation	proliferation	NN
cord-341968-uc8i9h0m	25	45	,	,	,
cord-341968-uc8i9h0m	25	46	and	and	CC
cord-341968-uc8i9h0m	25	47	differentiation	differentiation	NN
cord-341968-uc8i9h0m	25	48	[	[	-LRB-
cord-341968-uc8i9h0m	25	49	11	11	CD
cord-341968-uc8i9h0m	25	50	]	]	-RRB-
cord-341968-uc8i9h0m	26	1	[	[	-LRB-
cord-341968-uc8i9h0m	26	2	12	12	CD
cord-341968-uc8i9h0m	26	3	]	]	-RRB-
cord-341968-uc8i9h0m	26	4	[	[	-LRB-
cord-341968-uc8i9h0m	26	5	13	13	CD
cord-341968-uc8i9h0m	26	6	]	]	-RRB-
cord-341968-uc8i9h0m	26	7	.	.	.
cord-341968-uc8i9h0m	27	1	The	the	DT
cord-341968-uc8i9h0m	27	2	gene	gene	NN
cord-341968-uc8i9h0m	27	3	expression	expression	NN
cord-341968-uc8i9h0m	27	4	profile	profile	NN
cord-341968-uc8i9h0m	27	5	of	of	IN
cord-341968-uc8i9h0m	27	6	the	the	DT
cord-341968-uc8i9h0m	27	7	Kexin	Kexin	NNP
cord-341968-uc8i9h0m	27	8	-	-	HYPH
cord-341968-uc8i9h0m	27	9	like	like	JJ
cord-341968-uc8i9h0m	27	10	PCs	pc	NNS
cord-341968-uc8i9h0m	27	11	is	be	VBZ
cord-341968-uc8i9h0m	27	12	cell	cell	NN
cord-341968-uc8i9h0m	27	13	-	-	HYPH
cord-341968-uc8i9h0m	27	14	type	type	NN
cord-341968-uc8i9h0m	27	15	dependent	dependent	JJ
cord-341968-uc8i9h0m	27	16	,	,	,
cord-341968-uc8i9h0m	27	17	but	but	CC
cord-341968-uc8i9h0m	27	18	most	most	JJS
cord-341968-uc8i9h0m	27	19	cells	cell	NNS
cord-341968-uc8i9h0m	27	20	express	express	VBP
cord-341968-uc8i9h0m	27	21	some	some	DT
cord-341968-uc8i9h0m	27	22	or	or	CC
cord-341968-uc8i9h0m	27	23	all	all	DT
cord-341968-uc8i9h0m	27	24	of	of	IN
cord-341968-uc8i9h0m	27	25	them	-PRON-	PRP
cord-341968-uc8i9h0m	27	26	,	,	,
cord-341968-uc8i9h0m	27	27	except	except	IN
cord-341968-uc8i9h0m	27	28	for	for	IN
cord-341968-uc8i9h0m	27	29	PC4	pc4	NN
cord-341968-uc8i9h0m	27	30	whose	whose	WP$
cord-341968-uc8i9h0m	27	31	expression	expression	NN
cord-341968-uc8i9h0m	27	32	is	be	VBZ
cord-341968-uc8i9h0m	27	33	restricted	restrict	VBN
cord-341968-uc8i9h0m	27	34	to	to	IN
cord-341968-uc8i9h0m	27	35	cell	cell	NN
cord-341968-uc8i9h0m	27	36	types	type	NNS
cord-341968-uc8i9h0m	27	37	in	in	IN
cord-341968-uc8i9h0m	27	38	the	the	DT
cord-341968-uc8i9h0m	27	39	testes	testis	NNS
cord-341968-uc8i9h0m	27	40	,	,	,
cord-341968-uc8i9h0m	27	41	ovaries	ovary	NNS
cord-341968-uc8i9h0m	27	42	and	and	CC
cord-341968-uc8i9h0m	27	43	the	the	DT
cord-341968-uc8i9h0m	27	44	placenta	placenta	NN
cord-341968-uc8i9h0m	27	45	.	.	.
cord-341968-uc8i9h0m	28	1	PCs	pc	NNS
cord-341968-uc8i9h0m	28	2	are	be	VBP
cord-341968-uc8i9h0m	28	3	large	large	JJ
cord-341968-uc8i9h0m	28	4	-	-	HYPH
cord-341968-uc8i9h0m	28	5	size	size	NN
cord-341968-uc8i9h0m	28	6	multidomain	multidomain	NN
cord-341968-uc8i9h0m	28	7	proteins	protein	NNS
cord-341968-uc8i9h0m	28	8	composed	compose	VBN
cord-341968-uc8i9h0m	28	9	of	of	IN
cord-341968-uc8i9h0m	28	10	conserved	conserve	VBN
cord-341968-uc8i9h0m	28	11	catalytic	catalytic	JJ
cord-341968-uc8i9h0m	28	12	and	and	CC
cord-341968-uc8i9h0m	28	13	regulatory	regulatory	JJ
cord-341968-uc8i9h0m	28	14	P	p	NN
cord-341968-uc8i9h0m	28	15	domains	domain	NNS
cord-341968-uc8i9h0m	28	16	that	that	WDT
cord-341968-uc8i9h0m	28	17	share	share	VBP
cord-341968-uc8i9h0m	28	18	50%-65	50%-65	CD
cord-341968-uc8i9h0m	28	19	%	%	NN
cord-341968-uc8i9h0m	28	20	amino	amino	NN
cord-341968-uc8i9h0m	28	21	acid	acid	NN
cord-341968-uc8i9h0m	28	22	sequence	sequence	NN
cord-341968-uc8i9h0m	28	23	homology	homology	NN
cord-341968-uc8i9h0m	28	24	(	(	-LRB-
cord-341968-uc8i9h0m	28	25	Figure	figure	NN
cord-341968-uc8i9h0m	28	26	1	1	CD
cord-341968-uc8i9h0m	28	27	)	)	-RRB-
cord-341968-uc8i9h0m	28	28	.	.	.
cord-341968-uc8i9h0m	29	1	Furin	Furin	NNP
cord-341968-uc8i9h0m	29	2	,	,	,
cord-341968-uc8i9h0m	29	3	PC5	pc5	NN
cord-341968-uc8i9h0m	29	4	,	,	,
cord-341968-uc8i9h0m	29	5	and	and	CC
cord-341968-uc8i9h0m	29	6	PC7	PC7	NNS
cord-341968-uc8i9h0m	29	7	are	be	VBP
cord-341968-uc8i9h0m	29	8	type	type	NN
cord-341968-uc8i9h0m	29	9	I	-PRON-	PRP
cord-341968-uc8i9h0m	29	10	membrane	membrane	NN
cord-341968-uc8i9h0m	29	11	-	-	HYPH
cord-341968-uc8i9h0m	29	12	bound	bind	VBN
cord-341968-uc8i9h0m	29	13	proteins	protein	NNS
cord-341968-uc8i9h0m	29	14	,	,	,
cord-341968-uc8i9h0m	29	15	and	and	CC
cord-341968-uc8i9h0m	29	16	furin	furin	NN
cord-341968-uc8i9h0m	29	17	PCs	pc	NNS
cord-341968-uc8i9h0m	29	18	are	be	VBP
cord-341968-uc8i9h0m	29	19	eukaryotic	eukaryotic	JJ
cord-341968-uc8i9h0m	29	20	serine	serine	NN
cord-341968-uc8i9h0m	29	21	proteases	protease	NNS
cord-341968-uc8i9h0m	29	22	classified	classify	VBN
cord-341968-uc8i9h0m	29	23	in	in	IN
cord-341968-uc8i9h0m	29	24	the	the	DT
cord-341968-uc8i9h0m	29	25	MEROPS	MEROPS	NNP
cord-341968-uc8i9h0m	29	26	Peptidase	Peptidase	NNP
cord-341968-uc8i9h0m	29	27	Database	Database	NNP
cord-341968-uc8i9h0m	29	28	within	within	IN
cord-341968-uc8i9h0m	29	29	the	the	DT
cord-341968-uc8i9h0m	29	30	S8B	S8B	NNP
cord-341968-uc8i9h0m	29	31	family	family	NN
cord-341968-uc8i9h0m	29	32	.	.	.
cord-341968-uc8i9h0m	30	1	Furin	furin	NN
cord-341968-uc8i9h0m	30	2	,	,	,
cord-341968-uc8i9h0m	30	3	PC4	pc4	NN
cord-341968-uc8i9h0m	30	4	,	,	,
cord-341968-uc8i9h0m	30	5	PC5	PC5	NNP
cord-341968-uc8i9h0m	30	6	,	,	,
cord-341968-uc8i9h0m	30	7	PACE4	pace4	CD
cord-341968-uc8i9h0m	30	8	,	,	,
cord-341968-uc8i9h0m	30	9	and	and	CC
cord-341968-uc8i9h0m	30	10	PC7	PC7	NNS
cord-341968-uc8i9h0m	30	11	are	be	VBP
cord-341968-uc8i9h0m	30	12	part	part	NN
cord-341968-uc8i9h0m	30	13	of	of	IN
cord-341968-uc8i9h0m	30	14	the	the	DT
cord-341968-uc8i9h0m	30	15	Kexin	Kexin	NNP
cord-341968-uc8i9h0m	30	16	-	-	HYPH
cord-341968-uc8i9h0m	30	17	like	like	JJ
cord-341968-uc8i9h0m	30	18	subfamily	subfamily	NN
cord-341968-uc8i9h0m	30	19	of	of	IN
cord-341968-uc8i9h0m	30	20	PCs	pc	NNS
cord-341968-uc8i9h0m	30	21	and	and	CC
cord-341968-uc8i9h0m	30	22	localize	localize	VB
cord-341968-uc8i9h0m	30	23	to	to	IN
cord-341968-uc8i9h0m	30	24	the	the	DT
cord-341968-uc8i9h0m	30	25	organelles	organelle	NNS
cord-341968-uc8i9h0m	30	26	of	of	IN
cord-341968-uc8i9h0m	30	27	the	the	DT
cord-341968-uc8i9h0m	30	28	constitutive	constitutive	JJ
cord-341968-uc8i9h0m	30	29	protein	protein	NN
cord-341968-uc8i9h0m	30	30	secretion	secretion	NN
cord-341968-uc8i9h0m	30	31	pathway	pathway	NN
cord-341968-uc8i9h0m	30	32	[	[	-LRB-
cord-341968-uc8i9h0m	30	33	1	1	CD
cord-341968-uc8i9h0m	30	34	]	]	-RRB-
cord-341968-uc8i9h0m	30	35	.	.	.
cord-341968-uc8i9h0m	31	1	These	these	DT
cord-341968-uc8i9h0m	31	2	PCs	pc	NNS
cord-341968-uc8i9h0m	31	3	perform	perform	VBP
cord-341968-uc8i9h0m	31	4	the	the	DT
cord-341968-uc8i9h0m	31	5	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	31	6	post	post	JJ
cord-341968-uc8i9h0m	31	7	-	-	JJ
cord-341968-uc8i9h0m	31	8	translational	translational	JJ
cord-341968-uc8i9h0m	31	9	modification	modification	NN
cord-341968-uc8i9h0m	31	10	of	of	IN
cord-341968-uc8i9h0m	31	11	a	a	DT
cord-341968-uc8i9h0m	31	12	large	large	JJ
cord-341968-uc8i9h0m	31	13	variety	variety	NN
cord-341968-uc8i9h0m	31	14	of	of	IN
cord-341968-uc8i9h0m	31	15	peptides	peptide	NNS
cord-341968-uc8i9h0m	31	16	and	and	CC
cord-341968-uc8i9h0m	31	17	proteins	protein	NNS
cord-341968-uc8i9h0m	31	18	in	in	IN
cord-341968-uc8i9h0m	31	19	the	the	DT
cord-341968-uc8i9h0m	31	20	trans	trans	NNP
cord-341968-uc8i9h0m	31	21	-	-	NNP
cord-341968-uc8i9h0m	31	22	Golgi	Golgi	NNP
cord-341968-uc8i9h0m	31	23	network	network	NN
cord-341968-uc8i9h0m	31	24	,	,	,
cord-341968-uc8i9h0m	31	25	endosomes	endosome	NNS
cord-341968-uc8i9h0m	31	26	,	,	,
cord-341968-uc8i9h0m	31	27	and	and	CC
cord-341968-uc8i9h0m	31	28	pericellular	pericellular	JJ
cord-341968-uc8i9h0m	31	29	environment	environment	NN
cord-341968-uc8i9h0m	31	30	,	,	,
cord-341968-uc8i9h0m	31	31	and	and	CC
cord-341968-uc8i9h0m	31	32	are	be	VBP
cord-341968-uc8i9h0m	31	33	critical	critical	JJ
cord-341968-uc8i9h0m	31	34	regulators	regulator	NNS
cord-341968-uc8i9h0m	31	35	of	of	IN
cord-341968-uc8i9h0m	31	36	central	central	JJ
cord-341968-uc8i9h0m	31	37	cellular	cellular	JJ
cord-341968-uc8i9h0m	31	38	processes	process	NNS
cord-341968-uc8i9h0m	31	39	,	,	,
cord-341968-uc8i9h0m	31	40	such	such	JJ
cord-341968-uc8i9h0m	31	41	as	as	IN
cord-341968-uc8i9h0m	31	42	growth	growth	NN
cord-341968-uc8i9h0m	31	43	,	,	,
cord-341968-uc8i9h0m	31	44	proliferation	proliferation	NN
cord-341968-uc8i9h0m	31	45	,	,	,
cord-341968-uc8i9h0m	31	46	and	and	CC
cord-341968-uc8i9h0m	31	47	differentiation	differentiation	NN
cord-341968-uc8i9h0m	31	48	[	[	-LRB-
cord-341968-uc8i9h0m	31	49	11	11	CD
cord-341968-uc8i9h0m	31	50	]	]	-RRB-
cord-341968-uc8i9h0m	32	1	[	[	-LRB-
cord-341968-uc8i9h0m	32	2	12	12	CD
cord-341968-uc8i9h0m	32	3	]	]	-RRB-
cord-341968-uc8i9h0m	32	4	[	[	-LRB-
cord-341968-uc8i9h0m	32	5	13	13	CD
cord-341968-uc8i9h0m	32	6	]	]	-RRB-
cord-341968-uc8i9h0m	32	7	.	.	.
cord-341968-uc8i9h0m	33	1	The	the	DT
cord-341968-uc8i9h0m	33	2	gene	gene	NN
cord-341968-uc8i9h0m	33	3	expression	expression	NN
cord-341968-uc8i9h0m	33	4	profile	profile	NN
cord-341968-uc8i9h0m	33	5	of	of	IN
cord-341968-uc8i9h0m	33	6	the	the	DT
cord-341968-uc8i9h0m	33	7	Kexin	Kexin	NNP
cord-341968-uc8i9h0m	33	8	-	-	HYPH
cord-341968-uc8i9h0m	33	9	like	like	JJ
cord-341968-uc8i9h0m	33	10	PCs	pc	NNS
cord-341968-uc8i9h0m	33	11	is	be	VBZ
cord-341968-uc8i9h0m	33	12	cell	cell	NN
cord-341968-uc8i9h0m	33	13	-	-	HYPH
cord-341968-uc8i9h0m	33	14	type	type	NN
cord-341968-uc8i9h0m	33	15	dependent	dependent	JJ
cord-341968-uc8i9h0m	33	16	,	,	,
cord-341968-uc8i9h0m	33	17	but	but	CC
cord-341968-uc8i9h0m	33	18	most	most	JJS
cord-341968-uc8i9h0m	33	19	cells	cell	NNS
cord-341968-uc8i9h0m	33	20	express	express	VBP
cord-341968-uc8i9h0m	33	21	some	some	DT
cord-341968-uc8i9h0m	33	22	or	or	CC
cord-341968-uc8i9h0m	33	23	all	all	DT
cord-341968-uc8i9h0m	33	24	of	of	IN
cord-341968-uc8i9h0m	33	25	them	-PRON-	PRP
cord-341968-uc8i9h0m	33	26	,	,	,
cord-341968-uc8i9h0m	33	27	except	except	IN
cord-341968-uc8i9h0m	33	28	for	for	IN
cord-341968-uc8i9h0m	33	29	PC4	pc4	NN
cord-341968-uc8i9h0m	33	30	whose	whose	WP$
cord-341968-uc8i9h0m	33	31	expression	expression	NN
cord-341968-uc8i9h0m	33	32	is	be	VBZ
cord-341968-uc8i9h0m	33	33	restricted	restrict	VBN
cord-341968-uc8i9h0m	33	34	to	to	IN
cord-341968-uc8i9h0m	33	35	cell	cell	NN
cord-341968-uc8i9h0m	33	36	types	type	NNS
cord-341968-uc8i9h0m	33	37	in	in	IN
cord-341968-uc8i9h0m	33	38	the	the	DT
cord-341968-uc8i9h0m	33	39	testes	testis	NNS
cord-341968-uc8i9h0m	33	40	,	,	,
cord-341968-uc8i9h0m	33	41	ovaries	ovary	NNS
cord-341968-uc8i9h0m	33	42	and	and	CC
cord-341968-uc8i9h0m	33	43	the	the	DT
cord-341968-uc8i9h0m	33	44	placenta	placenta	NN
cord-341968-uc8i9h0m	33	45	.	.	.
cord-341968-uc8i9h0m	34	1	PCs	pc	NNS
cord-341968-uc8i9h0m	34	2	are	be	VBP
cord-341968-uc8i9h0m	34	3	large	large	JJ
cord-341968-uc8i9h0m	34	4	-	-	HYPH
cord-341968-uc8i9h0m	34	5	size	size	NN
cord-341968-uc8i9h0m	34	6	multidomain	multidomain	NN
cord-341968-uc8i9h0m	34	7	proteins	protein	NNS
cord-341968-uc8i9h0m	34	8	composed	compose	VBN
cord-341968-uc8i9h0m	34	9	of	of	IN
cord-341968-uc8i9h0m	34	10	conserved	conserve	VBN
cord-341968-uc8i9h0m	34	11	catalytic	catalytic	JJ
cord-341968-uc8i9h0m	34	12	and	and	CC
cord-341968-uc8i9h0m	34	13	regulatory	regulatory	JJ
cord-341968-uc8i9h0m	34	14	P	p	NN
cord-341968-uc8i9h0m	34	15	domains	domain	NNS
cord-341968-uc8i9h0m	34	16	that	that	WDT
cord-341968-uc8i9h0m	34	17	share	share	VBP
cord-341968-uc8i9h0m	34	18	50	50	CD
cord-341968-uc8i9h0m	34	19	-	-	SYM
cord-341968-uc8i9h0m	34	20	65	65	CD
cord-341968-uc8i9h0m	34	21	%	%	NN
cord-341968-uc8i9h0m	34	22	amino	amino	NN
cord-341968-uc8i9h0m	34	23	acid	acid	NN
cord-341968-uc8i9h0m	34	24	sequence	sequence	NN
cord-341968-uc8i9h0m	34	25	homology	homology	NN
cord-341968-uc8i9h0m	34	26	(	(	-LRB-
cord-341968-uc8i9h0m	34	27	Figure	figure	NN
cord-341968-uc8i9h0m	34	28	1	1	CD
cord-341968-uc8i9h0m	34	29	)	)	-RRB-
cord-341968-uc8i9h0m	34	30	.	.	.
cord-341968-uc8i9h0m	35	1	Furin	Furin	NNP
cord-341968-uc8i9h0m	35	2	,	,	,
cord-341968-uc8i9h0m	35	3	PC5	pc5	NN
cord-341968-uc8i9h0m	35	4	,	,	,
cord-341968-uc8i9h0m	35	5	and	and	CC
cord-341968-uc8i9h0m	35	6	PC7	PC7	NNS
cord-341968-uc8i9h0m	35	7	are	be	VBP
cord-341968-uc8i9h0m	35	8	type	type	NN
cord-341968-uc8i9h0m	36	1	I	-PRON-	PRP
cord-341968-uc8i9h0m	36	2	membrane	membrane	NN
cord-341968-uc8i9h0m	36	3	-	-	HYPH
cord-341968-uc8i9h0m	36	4	bound	bind	VBN
cord-341968-uc8i9h0m	36	5	proteins	protein	NNS
cord-341968-uc8i9h0m	36	6	,	,	,
cord-341968-uc8i9h0m	36	7	and	and	CC
cord-341968-uc8i9h0m	36	8	furin	furin	NN
cord-341968-uc8i9h0m	36	9	and	and	CC
cord-341968-uc8i9h0m	36	10	PC5	PC5	NNP
cord-341968-uc8i9h0m	36	11	can	can	MD
cord-341968-uc8i9h0m	36	12	be	be	VB
cord-341968-uc8i9h0m	36	13	shed	shed	VBN
cord-341968-uc8i9h0m	36	14	extracellularly	extracellularly	RB
cord-341968-uc8i9h0m	36	15	;	;	:
cord-341968-uc8i9h0m	36	16	in	in	IN
cord-341968-uc8i9h0m	36	17	contrast	contrast	NN
cord-341968-uc8i9h0m	36	18	,	,	,
cord-341968-uc8i9h0m	36	19	PACE4	PACE4	NNP
cord-341968-uc8i9h0m	36	20	is	be	VBZ
cord-341968-uc8i9h0m	36	21	a	a	DT
cord-341968-uc8i9h0m	36	22	secreted	secrete	VBN
cord-341968-uc8i9h0m	36	23	protein	protein	NN
cord-341968-uc8i9h0m	36	24	.	.	.
cord-341968-uc8i9h0m	37	1	Kexin	Kexin	NNP
cord-341968-uc8i9h0m	37	2	-	-	HYPH
cord-341968-uc8i9h0m	37	3	like	like	JJ
cord-341968-uc8i9h0m	37	4	PCs	pc	NNS
cord-341968-uc8i9h0m	37	5	cleave	cleave	VBP
cord-341968-uc8i9h0m	37	6	their	-PRON-	PRP$
cord-341968-uc8i9h0m	37	7	substrates	substrate	NNS
cord-341968-uc8i9h0m	37	8	at	at	IN
cord-341968-uc8i9h0m	37	9	sites	site	NNS
cord-341968-uc8i9h0m	37	10	specified	specify	VBN
cord-341968-uc8i9h0m	37	11	by	by	IN
cord-341968-uc8i9h0m	37	12	a	a	DT
cord-341968-uc8i9h0m	37	13	motif	motif	NN
cord-341968-uc8i9h0m	37	14	composed	compose	VBN
cord-341968-uc8i9h0m	37	15	of	of	IN
cord-341968-uc8i9h0m	37	16	P4Arg	p4arg	NN
cord-341968-uc8i9h0m	37	17	-	-	HYPH
cord-341968-uc8i9h0m	37	18	P3X	p3x	CD
cord-341968-uc8i9h0m	37	19	-	-	HYPH
cord-341968-uc8i9h0m	37	20	P2X	p2x	NN
cord-341968-uc8i9h0m	37	21	-	-	HYPH
cord-341968-uc8i9h0m	37	22	P1Arg	P1Arg	NNP
cord-341968-uc8i9h0m	37	23	-	-	HYPH
cord-341968-uc8i9h0m	37	24	P1	P1	NNP
cord-341968-uc8i9h0m	37	25	X	X	NNP
cord-341968-uc8i9h0m	37	26	,	,	,
cord-341968-uc8i9h0m	37	27	where	where	WRB
cord-341968-uc8i9h0m	37	28	X	x	NN
cord-341968-uc8i9h0m	37	29	is	be	VBZ
cord-341968-uc8i9h0m	37	30	any	any	DT
cord-341968-uc8i9h0m	37	31	amino	amino	NN
cord-341968-uc8i9h0m	37	32	acid	acid	NN
cord-341968-uc8i9h0m	37	33	residue	residue	NN
cord-341968-uc8i9h0m	37	34	,	,	,
cord-341968-uc8i9h0m	37	35	and	and	CC
cord-341968-uc8i9h0m	37	36	cleavage	cleavage	NN
cord-341968-uc8i9h0m	37	37	occurs	occur	VBZ
cord-341968-uc8i9h0m	37	38	between	between	IN
cord-341968-uc8i9h0m	37	39	the	the	DT
cord-341968-uc8i9h0m	37	40	P1Arg	P1Arg	NNP
cord-341968-uc8i9h0m	37	41	and	and	CC
cord-341968-uc8i9h0m	37	42	P1	P1	NNP
cord-341968-uc8i9h0m	37	43	X	x	NN
cord-341968-uc8i9h0m	37	44	residues	residue	NNS
cord-341968-uc8i9h0m	37	45	.	.	.
cord-341968-uc8i9h0m	38	1	This	this	DT
cord-341968-uc8i9h0m	38	2	sequence	sequence	NN
cord-341968-uc8i9h0m	38	3	motif	motif	NN
cord-341968-uc8i9h0m	38	4	is	be	VBZ
cord-341968-uc8i9h0m	38	5	found	find	VBN
cord-341968-uc8i9h0m	38	6	in	in	IN
cord-341968-uc8i9h0m	38	7	many	many	JJ
cord-341968-uc8i9h0m	38	8	viral	viral	JJ
cord-341968-uc8i9h0m	38	9	surface	surface	NN
cord-341968-uc8i9h0m	38	10	proteins	protein	NNS
cord-341968-uc8i9h0m	38	11	and	and	CC
cord-341968-uc8i9h0m	38	12	determines	determine	VBZ
cord-341968-uc8i9h0m	38	13	cleavage	cleavage	NN
cord-341968-uc8i9h0m	38	14	by	by	IN
cord-341968-uc8i9h0m	38	15	PCs	pc	NNS
cord-341968-uc8i9h0m	38	16	[	[	-LRB-
cord-341968-uc8i9h0m	38	17	3	3	CD
cord-341968-uc8i9h0m	38	18	]	]	-RRB-
cord-341968-uc8i9h0m	38	19	.	.	.
cord-341968-uc8i9h0m	39	1	The	the	DT
cord-341968-uc8i9h0m	39	2	Kexin	Kexin	NNP
cord-341968-uc8i9h0m	39	3	-	-	HYPH
cord-341968-uc8i9h0m	39	4	like	like	JJ
cord-341968-uc8i9h0m	39	5	PCs	pc	NNS
cord-341968-uc8i9h0m	39	6	are	be	VBP
cord-341968-uc8i9h0m	39	7	divided	divide	VBN
cord-341968-uc8i9h0m	39	8	into	into	IN
cord-341968-uc8i9h0m	39	9	two	two	CD
cord-341968-uc8i9h0m	39	10	specificity	specificity	NN
cord-341968-uc8i9h0m	39	11	groups	group	NNS
cord-341968-uc8i9h0m	39	12	,	,	,
cord-341968-uc8i9h0m	39	13	one	one	CD
cord-341968-uc8i9h0m	39	14	represented	represent	VBN
cord-341968-uc8i9h0m	39	15	by	by	IN
cord-341968-uc8i9h0m	39	16	furin	furin	NN
cord-341968-uc8i9h0m	39	17	,	,	,
cord-341968-uc8i9h0m	39	18	and	and	CC
cord-341968-uc8i9h0m	39	19	the	the	DT
cord-341968-uc8i9h0m	39	20	other	other	JJ
cord-341968-uc8i9h0m	39	21	by	by	IN
cord-341968-uc8i9h0m	39	22	PC4	PC4	NNP
cord-341968-uc8i9h0m	39	23	/	/	SYM
cord-341968-uc8i9h0m	39	24	PC5	PC5	NNP
cord-341968-uc8i9h0m	39	25	/	/	SYM
cord-341968-uc8i9h0m	39	26	PACE4	PACE4	NNP
cord-341968-uc8i9h0m	40	1	/PC7	/PC7	:
cord-341968-uc8i9h0m	40	2	[	[	-LRB-
cord-341968-uc8i9h0m	40	3	9	9	CD
cord-341968-uc8i9h0m	40	4	]	]	-RRB-
cord-341968-uc8i9h0m	40	5	.	.	.
cord-341968-uc8i9h0m	41	1	Furin	Furin	NNP
cord-341968-uc8i9h0m	41	2	is	be	VBZ
cord-341968-uc8i9h0m	41	3	Viruses	virus	NNS
cord-341968-uc8i9h0m	41	4	2019	2019	CD
cord-341968-uc8i9h0m	41	5	,	,	,
cord-341968-uc8i9h0m	41	6	11	11	CD
cord-341968-uc8i9h0m	41	7	,	,	,
cord-341968-uc8i9h0m	41	8	837	837	CD
cord-341968-uc8i9h0m	41	9	3	3	CD
cord-341968-uc8i9h0m	41	10	of	of	IN
cord-341968-uc8i9h0m	41	11	19	19	CD
cord-341968-uc8i9h0m	41	12	more	more	RBR
cord-341968-uc8i9h0m	41	13	reactive	reactive	JJ
cord-341968-uc8i9h0m	41	14	than	than	IN
cord-341968-uc8i9h0m	41	15	the	the	DT
cord-341968-uc8i9h0m	41	16	other	other	JJ
cord-341968-uc8i9h0m	41	17	PCs	pc	NNS
cord-341968-uc8i9h0m	41	18	,	,	,
cord-341968-uc8i9h0m	41	19	and	and	CC
cord-341968-uc8i9h0m	41	20	the	the	DT
cord-341968-uc8i9h0m	41	21	differences	difference	NNS
cord-341968-uc8i9h0m	41	22	in	in	IN
cord-341968-uc8i9h0m	41	23	reaction	reaction	NN
cord-341968-uc8i9h0m	41	24	specificity	specificity	NN
cord-341968-uc8i9h0m	41	25	between	between	IN
cord-341968-uc8i9h0m	41	26	the	the	DT
cord-341968-uc8i9h0m	41	27	two	two	CD
cord-341968-uc8i9h0m	41	28	groups	group	NNS
cord-341968-uc8i9h0m	41	29	are	be	VBP
cord-341968-uc8i9h0m	41	30	based	base	VBN
cord-341968-uc8i9h0m	41	31	on	on	IN
cord-341968-uc8i9h0m	41	32	active	active	JJ
cord-341968-uc8i9h0m	41	33	-	-	HYPH
cord-341968-uc8i9h0m	41	34	site	site	NN
cord-341968-uc8i9h0m	41	35	and	and	CC
cord-341968-uc8i9h0m	41	36	exosite	exosite	JJ
cord-341968-uc8i9h0m	41	37	determinants	determinant	NNS
cord-341968-uc8i9h0m	41	38	of	of	IN
cord-341968-uc8i9h0m	41	39	reactivity	reactivity	NN
cord-341968-uc8i9h0m	41	40	.	.	.
cord-341968-uc8i9h0m	42	1	Kexin	Kexin	NNP
cord-341968-uc8i9h0m	42	2	-	-	HYPH
cord-341968-uc8i9h0m	42	3	like	like	JJ
cord-341968-uc8i9h0m	42	4	PCs	pc	NNS
cord-341968-uc8i9h0m	42	5	are	be	VBP
cord-341968-uc8i9h0m	42	6	considered	consider	VBN
cord-341968-uc8i9h0m	42	7	potential	potential	JJ
cord-341968-uc8i9h0m	42	8	pharmacological	pharmacological	JJ
cord-341968-uc8i9h0m	42	9	targets	target	NNS
cord-341968-uc8i9h0m	42	10	for	for	IN
cord-341968-uc8i9h0m	42	11	the	the	DT
cord-341968-uc8i9h0m	42	12	treatment	treatment	NN
cord-341968-uc8i9h0m	42	13	of	of	IN
cord-341968-uc8i9h0m	42	14	viral	viral	JJ
cord-341968-uc8i9h0m	42	15	infections	infection	NNS
cord-341968-uc8i9h0m	42	16	by	by	IN
cord-341968-uc8i9h0m	42	17	blocking	block	VBG
cord-341968-uc8i9h0m	42	18	virus	virus	NN
cord-341968-uc8i9h0m	42	19	maturation	maturation	NN
cord-341968-uc8i9h0m	42	20	and	and	CC
cord-341968-uc8i9h0m	42	21	infectivity	infectivity	NN
cord-341968-uc8i9h0m	42	22	.	.	.
cord-341968-uc8i9h0m	43	1	Other	other	JJ
cord-341968-uc8i9h0m	43	2	uses	use	VBZ
cord-341968-uc8i9h0m	43	3	for	for	IN
cord-341968-uc8i9h0m	43	4	the	the	DT
cord-341968-uc8i9h0m	43	5	targeting	targeting	NN
cord-341968-uc8i9h0m	43	6	of	of	IN
cord-341968-uc8i9h0m	43	7	these	these	DT
cord-341968-uc8i9h0m	43	8	PCs	pc	NNS
cord-341968-uc8i9h0m	43	9	include	include	VBP
cord-341968-uc8i9h0m	43	10	the	the	DT
cord-341968-uc8i9h0m	43	11	inhibition	inhibition	NN
cord-341968-uc8i9h0m	43	12	of	of	IN
cord-341968-uc8i9h0m	43	13	the	the	DT
cord-341968-uc8i9h0m	43	14	activation	activation	NN
cord-341968-uc8i9h0m	43	15	of	of	IN
cord-341968-uc8i9h0m	43	16	bacterial	bacterial	JJ
cord-341968-uc8i9h0m	43	17	toxins	toxin	NNS
cord-341968-uc8i9h0m	43	18	such	such	JJ
cord-341968-uc8i9h0m	43	19	as	as	IN
cord-341968-uc8i9h0m	43	20	Shiga	Shiga	NNP
cord-341968-uc8i9h0m	43	21	,	,	,
cord-341968-uc8i9h0m	43	22	anthrax	anthrax	NN
cord-341968-uc8i9h0m	43	23	,	,	,
cord-341968-uc8i9h0m	43	24	Clostridium	clostridium	NN
cord-341968-uc8i9h0m	43	25	,	,	,
cord-341968-uc8i9h0m	43	26	Pseudomonas	Pseudomonas	NNP
cord-341968-uc8i9h0m	43	27	,	,	,
cord-341968-uc8i9h0m	43	28	and	and	CC
cord-341968-uc8i9h0m	43	29	diphtheria	diphtheria	NN
cord-341968-uc8i9h0m	43	30	;	;	:
cord-341968-uc8i9h0m	43	31	and	and	CC
cord-341968-uc8i9h0m	43	32	also	also	RB
cord-341968-uc8i9h0m	43	33	,	,	,
cord-341968-uc8i9h0m	43	34	for	for	IN
cord-341968-uc8i9h0m	43	35	the	the	DT
cord-341968-uc8i9h0m	43	36	treatment	treatment	NN
cord-341968-uc8i9h0m	43	37	of	of	IN
cord-341968-uc8i9h0m	43	38	degenerative	degenerative	JJ
cord-341968-uc8i9h0m	43	39	diseases	disease	NNS
cord-341968-uc8i9h0m	43	40	such	such	JJ
cord-341968-uc8i9h0m	43	41	as	as	IN
cord-341968-uc8i9h0m	43	42	metastatic	metastatic	JJ
cord-341968-uc8i9h0m	43	43	cancer	cancer	NN
cord-341968-uc8i9h0m	43	44	,	,	,
cord-341968-uc8i9h0m	43	45	Alzheimer	Alzheimer	NNP
cord-341968-uc8i9h0m	43	46	's	's	POS
cord-341968-uc8i9h0m	43	47	,	,	,
cord-341968-uc8i9h0m	43	48	and	and	CC
cord-341968-uc8i9h0m	43	49	osteoarthritis	osteoarthritis	NN
cord-341968-uc8i9h0m	43	50	[	[	-LRB-
cord-341968-uc8i9h0m	43	51	2	2	CD
cord-341968-uc8i9h0m	43	52	,	,	,
cord-341968-uc8i9h0m	43	53	4	4	CD
cord-341968-uc8i9h0m	43	54	,	,	,
cord-341968-uc8i9h0m	43	55	5	5	CD
cord-341968-uc8i9h0m	43	56	]	]	-RRB-
cord-341968-uc8i9h0m	43	57	.	.	.
cord-341968-uc8i9h0m	44	1	The	the	DT
cord-341968-uc8i9h0m	44	2	only	only	RB
cord-341968-uc8i9h0m	44	3	known	know	VBN
cord-341968-uc8i9h0m	44	4	natural	natural	JJ
cord-341968-uc8i9h0m	44	5	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	44	6	of	of	IN
cord-341968-uc8i9h0m	44	7	PCs	pc	NNS
cord-341968-uc8i9h0m	44	8	are	be	VBP
cord-341968-uc8i9h0m	44	9	serpins	serpin	NNS
cord-341968-uc8i9h0m	44	10	,	,	,
cord-341968-uc8i9h0m	44	11	which	which	WDT
cord-341968-uc8i9h0m	44	12	are	be	VBP
cord-341968-uc8i9h0m	44	13	slow	slow	RB
cord-341968-uc8i9h0m	44	14	-	-	HYPH
cord-341968-uc8i9h0m	44	15	binding	bind	VBG
cord-341968-uc8i9h0m	44	16	type	type	NN
cord-341968-uc8i9h0m	44	17	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	44	18	that	that	WDT
cord-341968-uc8i9h0m	44	19	form	form	VBP
cord-341968-uc8i9h0m	44	20	covalently	covalently	RB
cord-341968-uc8i9h0m	44	21	-	-	HYPH
cord-341968-uc8i9h0m	44	22	linked	link	VBN
cord-341968-uc8i9h0m	44	23	inhibitory	inhibitory	JJ
cord-341968-uc8i9h0m	44	24	complexes	complex	NNS
cord-341968-uc8i9h0m	44	25	with	with	IN
cord-341968-uc8i9h0m	44	26	their	-PRON-	PRP$
cord-341968-uc8i9h0m	44	27	target	target	NN
cord-341968-uc8i9h0m	44	28	proteases	protease	NNS
cord-341968-uc8i9h0m	44	29	[	[	-LRB-
cord-341968-uc8i9h0m	44	30	14	14	CD
cord-341968-uc8i9h0m	44	31	]	]	-RRB-
cord-341968-uc8i9h0m	44	32	.	.	.
cord-341968-uc8i9h0m	45	1	Serpin	Serpin	NNP
cord-341968-uc8i9h0m	45	2	B8	B8	NNP
cord-341968-uc8i9h0m	45	3	,	,	,
cord-341968-uc8i9h0m	45	4	currently	currently	RB
cord-341968-uc8i9h0m	45	5	the	the	DT
cord-341968-uc8i9h0m	45	6	only	only	JJ
cord-341968-uc8i9h0m	45	7	PC	pc	NN
cord-341968-uc8i9h0m	45	8	inhibitory	inhibitory	JJ
cord-341968-uc8i9h0m	45	9	serpin	serpin	NN
cord-341968-uc8i9h0m	45	10	identified	identify	VBN
cord-341968-uc8i9h0m	45	11	in	in	IN
cord-341968-uc8i9h0m	45	12	vertebrates	vertebrate	NNS
cord-341968-uc8i9h0m	45	13	,	,	,
cord-341968-uc8i9h0m	45	14	has	have	VBZ
cord-341968-uc8i9h0m	45	15	higher	high	JJR
cord-341968-uc8i9h0m	45	16	specificity	specificity	NN
cord-341968-uc8i9h0m	45	17	for	for	IN
cord-341968-uc8i9h0m	45	18	furin	furin	NN
cord-341968-uc8i9h0m	45	19	than	than	IN
cord-341968-uc8i9h0m	45	20	for	for	IN
cord-341968-uc8i9h0m	46	1	PC4	PC4	NNP
cord-341968-uc8i9h0m	46	2	/	/	SYM
cord-341968-uc8i9h0m	46	3	PC5	PC5	NNP
cord-341968-uc8i9h0m	46	4	/	/	SYM
cord-341968-uc8i9h0m	46	5	PACE4	PACE4	NNP
cord-341968-uc8i9h0m	46	6	/	/	SYM
cord-341968-uc8i9h0m	46	7	PC7	pc7	NN
cord-341968-uc8i9h0m	46	8	[	[	-LRB-
cord-341968-uc8i9h0m	46	9	9	9	CD
cord-341968-uc8i9h0m	46	10	,	,	,
cord-341968-uc8i9h0m	46	11	15	15	CD
cord-341968-uc8i9h0m	46	12	,	,	,
cord-341968-uc8i9h0m	46	13	16	16	CD
cord-341968-uc8i9h0m	46	14	]	]	-RRB-
cord-341968-uc8i9h0m	46	15	.	.	.
cord-341968-uc8i9h0m	47	1	More	More	JJR
cord-341968-uc8i9h0m	47	2	PC	pc	NN
cord-341968-uc8i9h0m	47	3	inhibitory	inhibitory	JJ
cord-341968-uc8i9h0m	47	4	serpins	serpin	NNS
cord-341968-uc8i9h0m	47	5	have	have	VBP
cord-341968-uc8i9h0m	47	6	been	be	VBN
cord-341968-uc8i9h0m	47	7	characterized	characterize	VBN
cord-341968-uc8i9h0m	47	8	in	in	IN
cord-341968-uc8i9h0m	47	9	other	other	JJ
cord-341968-uc8i9h0m	47	10	organisms	organism	NNS
cord-341968-uc8i9h0m	47	11	as	as	RB
cord-341968-uc8i9h0m	47	12	well	well	RB
cord-341968-uc8i9h0m	47	13	[	[	-LRB-
cord-341968-uc8i9h0m	47	14	17	17	CD
cord-341968-uc8i9h0m	47	15	]	]	-RRB-
cord-341968-uc8i9h0m	47	16	[	[	-LRB-
cord-341968-uc8i9h0m	47	17	18	18	CD
cord-341968-uc8i9h0m	47	18	]	]	-RRB-
cord-341968-uc8i9h0m	47	19	[	[	-LRB-
cord-341968-uc8i9h0m	47	20	19	19	CD
cord-341968-uc8i9h0m	47	21	]	]	-RRB-
cord-341968-uc8i9h0m	47	22	.	.	.
cord-341968-uc8i9h0m	48	1	A	a	DT
cord-341968-uc8i9h0m	48	2	variety	variety	NN
cord-341968-uc8i9h0m	48	3	of	of	IN
cord-341968-uc8i9h0m	48	4	synthetic	synthetic	JJ
cord-341968-uc8i9h0m	48	5	PC	pc	NN
cord-341968-uc8i9h0m	48	6	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	48	7	have	have	VBP
cord-341968-uc8i9h0m	48	8	been	be	VBN
cord-341968-uc8i9h0m	48	9	developed	develop	VBN
cord-341968-uc8i9h0m	48	10	based	base	VBN
cord-341968-uc8i9h0m	48	11	on	on	IN
cord-341968-uc8i9h0m	48	12	small	small	JJ
cord-341968-uc8i9h0m	48	13	molecules	molecule	NNS
cord-341968-uc8i9h0m	48	14	,	,	,
cord-341968-uc8i9h0m	48	15	peptides	peptide	NNS
cord-341968-uc8i9h0m	48	16	and	and	CC
cord-341968-uc8i9h0m	48	17	their	-PRON-	PRP$
cord-341968-uc8i9h0m	48	18	mimetic	mimetic	JJ
cord-341968-uc8i9h0m	48	19	derivatives	derivative	NNS
cord-341968-uc8i9h0m	48	20	,	,	,
cord-341968-uc8i9h0m	48	21	and	and	CC
cord-341968-uc8i9h0m	48	22	larger	large	JJR
cord-341968-uc8i9h0m	48	23	proteins	protein	NNS
cord-341968-uc8i9h0m	48	24	[	[	-LRB-
cord-341968-uc8i9h0m	48	25	5	5	CD
cord-341968-uc8i9h0m	48	26	,	,	,
cord-341968-uc8i9h0m	48	27	20	20	CD
cord-341968-uc8i9h0m	48	28	]	]	-RRB-
cord-341968-uc8i9h0m	48	29	.	.	.
cord-341968-uc8i9h0m	49	1	However	however	RB
cord-341968-uc8i9h0m	49	2	,	,	,
cord-341968-uc8i9h0m	49	3	the	the	DT
cord-341968-uc8i9h0m	49	4	main	main	JJ
cord-341968-uc8i9h0m	49	5	obstacle	obstacle	NN
cord-341968-uc8i9h0m	49	6	for	for	IN
cord-341968-uc8i9h0m	49	7	their	-PRON-	PRP$
cord-341968-uc8i9h0m	49	8	therapeutic	therapeutic	JJ
cord-341968-uc8i9h0m	49	9	use	use	NN
cord-341968-uc8i9h0m	49	10	has	have	VBZ
cord-341968-uc8i9h0m	49	11	been	be	VBN
cord-341968-uc8i9h0m	49	12	their	-PRON-	PRP$
cord-341968-uc8i9h0m	49	13	toxicity	toxicity	NN
cord-341968-uc8i9h0m	49	14	,	,	,
cord-341968-uc8i9h0m	49	15	and	and	CC
cord-341968-uc8i9h0m	49	16	their	-PRON-	PRP$
cord-341968-uc8i9h0m	49	17	lack	lack	NN
cord-341968-uc8i9h0m	49	18	of	of	IN
cord-341968-uc8i9h0m	49	19	PC	pc	NN
cord-341968-uc8i9h0m	49	20	selectivity	selectivity	NN
cord-341968-uc8i9h0m	49	21	.	.	.
cord-341968-uc8i9h0m	50	1	An	an	DT
cord-341968-uc8i9h0m	50	2	important	important	JJ
cord-341968-uc8i9h0m	50	3	research	research	NN
cord-341968-uc8i9h0m	50	4	tool	tool	NN
cord-341968-uc8i9h0m	50	5	is	be	VBZ
cord-341968-uc8i9h0m	50	6	the	the	DT
cord-341968-uc8i9h0m	50	7	PC	pc	NN
cord-341968-uc8i9h0m	50	8	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	50	9	α1PDX	α1PDX	NNP
cord-341968-uc8i9h0m	50	10	,	,	,
cord-341968-uc8i9h0m	50	11	which	which	WDT
cord-341968-uc8i9h0m	50	12	is	be	VBZ
cord-341968-uc8i9h0m	50	13	a	a	DT
cord-341968-uc8i9h0m	50	14	derivative	derivative	NN
cord-341968-uc8i9h0m	50	15	of	of	IN
cord-341968-uc8i9h0m	50	16	the	the	DT
cord-341968-uc8i9h0m	50	17	serpin	serpin	NN
cord-341968-uc8i9h0m	50	18	α1-antitrypsin	α1-antitrypsin	XX
cord-341968-uc8i9h0m	50	19	with	with	IN
cord-341968-uc8i9h0m	50	20	an	an	DT
cord-341968-uc8i9h0m	50	21	engineered	engineer	VBN
cord-341968-uc8i9h0m	50	22	PC	pc	NN
cord-341968-uc8i9h0m	50	23	cleavage	cleavage	NN
cord-341968-uc8i9h0m	50	24	site	site	NN
cord-341968-uc8i9h0m	50	25	motif	motif	NN
cord-341968-uc8i9h0m	50	26	at	at	IN
cord-341968-uc8i9h0m	50	27	its	-PRON-	PRP$
cord-341968-uc8i9h0m	50	28	reactive	reactive	JJ
cord-341968-uc8i9h0m	50	29	loop	loop	NN
cord-341968-uc8i9h0m	50	30	[	[	-LRB-
cord-341968-uc8i9h0m	50	31	21	21	CD
cord-341968-uc8i9h0m	50	32	]	]	-RRB-
cord-341968-uc8i9h0m	50	33	.	.	.
cord-341968-uc8i9h0m	51	1	This	this	DT
cord-341968-uc8i9h0m	51	2	engineered	engineer	VBN
cord-341968-uc8i9h0m	51	3	serpin	serpin	NN
cord-341968-uc8i9h0m	51	4	inhibits	inhibit	VBZ
cord-341968-uc8i9h0m	51	5	all	all	PDT
cord-341968-uc8i9h0m	51	6	the	the	DT
cord-341968-uc8i9h0m	51	7	Kexin	Kexin	NNP
cord-341968-uc8i9h0m	51	8	-	-	HYPH
cord-341968-uc8i9h0m	51	9	like	like	JJ
cord-341968-uc8i9h0m	51	10	PCs	pc	NNS
cord-341968-uc8i9h0m	51	11	with	with	IN
cord-341968-uc8i9h0m	51	12	the	the	DT
cord-341968-uc8i9h0m	51	13	same	same	JJ
cord-341968-uc8i9h0m	51	14	specificity	specificity	NN
cord-341968-uc8i9h0m	51	15	.	.	.
cord-341968-uc8i9h0m	52	1	More	more	RBR
cord-341968-uc8i9h0m	52	2	recently	recently	RB
cord-341968-uc8i9h0m	52	3	,	,	,
cord-341968-uc8i9h0m	52	4	we	-PRON-	PRP
cord-341968-uc8i9h0m	52	5	developed	develop	VBD
cord-341968-uc8i9h0m	52	6	two	two	CD
cord-341968-uc8i9h0m	52	7	α1PDX	α1PDX	NNP
cord-341968-uc8i9h0m	52	8	-	-	HYPH
cord-341968-uc8i9h0m	52	9	serpin	serpin	NN
cord-341968-uc8i9h0m	52	10	B8	b8	NN
cord-341968-uc8i9h0m	52	11	chimeras	chimera	NNS
cord-341968-uc8i9h0m	52	12	that	that	WDT
cord-341968-uc8i9h0m	52	13	selectively	selectively	RB
cord-341968-uc8i9h0m	52	14	target	target	VBP
cord-341968-uc8i9h0m	52	15	each	each	DT
cord-341968-uc8i9h0m	52	16	of	of	IN
cord-341968-uc8i9h0m	52	17	the	the	DT
cord-341968-uc8i9h0m	52	18	two	two	CD
cord-341968-uc8i9h0m	52	19	PC	pc	NN
cord-341968-uc8i9h0m	52	20	specificity	specificity	NN
cord-341968-uc8i9h0m	52	21	groups	group	NNS
cord-341968-uc8i9h0m	52	22	.	.	.
cord-341968-uc8i9h0m	53	1	One	one	CD
cord-341968-uc8i9h0m	53	2	is	be	VBZ
cord-341968-uc8i9h0m	53	3	α1ORD	α1ORD	NNP
cord-341968-uc8i9h0m	53	4	that	that	WDT
cord-341968-uc8i9h0m	53	5	specifically	specifically	RB
cord-341968-uc8i9h0m	53	6	inhibits	inhibit	VBZ
cord-341968-uc8i9h0m	53	7	furin	furin	NN
cord-341968-uc8i9h0m	53	8	,	,	,
cord-341968-uc8i9h0m	53	9	and	and	CC
cord-341968-uc8i9h0m	53	10	the	the	DT
cord-341968-uc8i9h0m	53	11	other	other	JJ
cord-341968-uc8i9h0m	53	12	is	be	VBZ
cord-341968-uc8i9h0m	53	13	α1MDW	α1MDW	NNP
cord-341968-uc8i9h0m	54	1	that	that	IN
cord-341968-uc8i9h0m	54	2	specifically	specifically	RB
cord-341968-uc8i9h0m	54	3	inhibits	inhibit	VBZ
cord-341968-uc8i9h0m	54	4	PC4	PC4	NNP
cord-341968-uc8i9h0m	54	5	/	/	SYM
cord-341968-uc8i9h0m	54	6	PC5	PC5	NNP
cord-341968-uc8i9h0m	54	7	/	/	SYM
cord-341968-uc8i9h0m	54	8	PACE4	PACE4	NNP
cord-341968-uc8i9h0m	55	1	/PC7	/PC7	:
cord-341968-uc8i9h0m	55	2	[	[	-LRB-
cord-341968-uc8i9h0m	55	3	8	8	CD
cord-341968-uc8i9h0m	55	4	,	,	,
cord-341968-uc8i9h0m	55	5	9	9	CD
cord-341968-uc8i9h0m	55	6	]	]	-RRB-
cord-341968-uc8i9h0m	55	7	.	.	.
cord-341968-uc8i9h0m	56	1	The	the	DT
cord-341968-uc8i9h0m	56	2	literature	literature	NN
cord-341968-uc8i9h0m	56	3	on	on	IN
cord-341968-uc8i9h0m	56	4	the	the	DT
cord-341968-uc8i9h0m	56	5	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	56	6	processing	processing	NN
cord-341968-uc8i9h0m	56	7	of	of	IN
cord-341968-uc8i9h0m	56	8	viral	viral	JJ
cord-341968-uc8i9h0m	56	9	surface	surface	NN
cord-341968-uc8i9h0m	56	10	proteins	protein	NNS
cord-341968-uc8i9h0m	56	11	by	by	IN
cord-341968-uc8i9h0m	56	12	PCs	pc	NNS
cord-341968-uc8i9h0m	56	13	and	and	CC
cord-341968-uc8i9h0m	56	14	the	the	DT
cord-341968-uc8i9h0m	56	15	role	role	NN
cord-341968-uc8i9h0m	56	16	that	that	IN
cord-341968-uc8i9h0m	56	17	PCs	pc	NNS
cord-341968-uc8i9h0m	56	18	play	play	VBP
cord-341968-uc8i9h0m	56	19	on	on	IN
cord-341968-uc8i9h0m	56	20	the	the	DT
cord-341968-uc8i9h0m	56	21	maturation	maturation	NN
cord-341968-uc8i9h0m	56	22	of	of	IN
cord-341968-uc8i9h0m	56	23	viruses	virus	NNS
cord-341968-uc8i9h0m	56	24	will	will	MD
cord-341968-uc8i9h0m	56	25	be	be	VB
cord-341968-uc8i9h0m	56	26	reviewed	review	VBN
cord-341968-uc8i9h0m	56	27	,	,	,
cord-341968-uc8i9h0m	56	28	and	and	CC
cord-341968-uc8i9h0m	56	29	finally	finally	RB
cord-341968-uc8i9h0m	56	30	,	,	,
cord-341968-uc8i9h0m	56	31	the	the	DT
cord-341968-uc8i9h0m	56	32	development	development	NN
cord-341968-uc8i9h0m	56	33	of	of	IN
cord-341968-uc8i9h0m	56	34	PC	pc	NN
cord-341968-uc8i9h0m	56	35	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	56	36	and	and	CC
cord-341968-uc8i9h0m	56	37	their	-PRON-	PRP$
cord-341968-uc8i9h0m	56	38	antiviral	antiviral	JJ
cord-341968-uc8i9h0m	56	39	properties	property	NNS
cord-341968-uc8i9h0m	56	40	will	will	MD
cord-341968-uc8i9h0m	56	41	be	be	VB
cord-341968-uc8i9h0m	56	42	discussed	discuss	VBN
cord-341968-uc8i9h0m	56	43	.	.	.
cord-341968-uc8i9h0m	57	1	The	the	DT
cord-341968-uc8i9h0m	57	2	human	human	JJ
cord-341968-uc8i9h0m	57	3	papillomavirus	papillomavirus	NN
cord-341968-uc8i9h0m	57	4	(	(	-LRB-
cord-341968-uc8i9h0m	57	5	HPV	HPV	NNP
cord-341968-uc8i9h0m	57	6	)	)	-RRB-
cord-341968-uc8i9h0m	57	7	infects	infect	VBZ
cord-341968-uc8i9h0m	57	8	the	the	DT
cord-341968-uc8i9h0m	57	9	basal	basal	NN
cord-341968-uc8i9h0m	57	10	cells	cell	NNS
cord-341968-uc8i9h0m	57	11	of	of	IN
cord-341968-uc8i9h0m	57	12	stratified	stratified	JJ
cord-341968-uc8i9h0m	57	13	epithelium	epithelium	NN
cord-341968-uc8i9h0m	57	14	,	,	,
cord-341968-uc8i9h0m	57	15	and	and	CC
cord-341968-uc8i9h0m	57	16	virion	virion	NN
cord-341968-uc8i9h0m	57	17	replication	replication	NN
cord-341968-uc8i9h0m	57	18	depends	depend	VBZ
cord-341968-uc8i9h0m	57	19	on	on	IN
cord-341968-uc8i9h0m	57	20	the	the	DT
cord-341968-uc8i9h0m	57	21	infected	infect	VBN
cord-341968-uc8i9h0m	57	22	basal	basal	NN
cord-341968-uc8i9h0m	57	23	cells	cell	NNS
cord-341968-uc8i9h0m	57	24	progressing	progress	VBG
cord-341968-uc8i9h0m	57	25	into	into	IN
cord-341968-uc8i9h0m	57	26	differentiated	differentiated	JJ
cord-341968-uc8i9h0m	57	27	squamous	squamous	JJ
cord-341968-uc8i9h0m	57	28	cells	cell	NNS
cord-341968-uc8i9h0m	57	29	.	.	.
cord-341968-uc8i9h0m	58	1	HPV	hpv	NN
cord-341968-uc8i9h0m	58	2	infects	infect	VBZ
cord-341968-uc8i9h0m	58	3	by	by	IN
cord-341968-uc8i9h0m	58	4	reaching	reach	VBG
cord-341968-uc8i9h0m	58	5	the	the	DT
cord-341968-uc8i9h0m	58	6	lower	low	JJR
cord-341968-uc8i9h0m	58	7	layers	layer	NNS
cord-341968-uc8i9h0m	58	8	of	of	IN
cord-341968-uc8i9h0m	58	9	the	the	DT
cord-341968-uc8i9h0m	58	10	stratified	stratified	JJ
cord-341968-uc8i9h0m	58	11	epithelium	epithelium	NN
cord-341968-uc8i9h0m	58	12	through	through	IN
cord-341968-uc8i9h0m	58	13	micro	micro	JJ
cord-341968-uc8i9h0m	58	14	-	-	NNS
cord-341968-uc8i9h0m	58	15	wounds	wound	NNS
cord-341968-uc8i9h0m	58	16	in	in	IN
cord-341968-uc8i9h0m	58	17	the	the	DT
cord-341968-uc8i9h0m	58	18	tissue	tissue	NN
cord-341968-uc8i9h0m	58	19	.	.	.
cord-341968-uc8i9h0m	59	1	There	there	RB
cord-341968-uc8i9h0m	59	2	,	,	,
cord-341968-uc8i9h0m	59	3	the	the	DT
cord-341968-uc8i9h0m	59	4	viral	viral	JJ
cord-341968-uc8i9h0m	59	5	particles	particle	NNS
cord-341968-uc8i9h0m	59	6	bind	bind	VBP
cord-341968-uc8i9h0m	59	7	to	to	IN
cord-341968-uc8i9h0m	59	8	heparin	heparin	NN
cord-341968-uc8i9h0m	59	9	sulfate	sulfate	NN
cord-341968-uc8i9h0m	59	10	proteoglycan	proteoglycan	NN
cord-341968-uc8i9h0m	59	11	receptors	receptor	NNS
cord-341968-uc8i9h0m	59	12	localized	localize	VBN
cord-341968-uc8i9h0m	59	13	either	either	CC
cord-341968-uc8i9h0m	59	14	on	on	IN
cord-341968-uc8i9h0m	59	15	the	the	DT
cord-341968-uc8i9h0m	59	16	extracellular	extracellular	JJ
cord-341968-uc8i9h0m	59	17	matrix	matrix	NN
cord-341968-uc8i9h0m	59	18	of	of	IN
cord-341968-uc8i9h0m	59	19	the	the	DT
cord-341968-uc8i9h0m	59	20	basement	basement	NN
cord-341968-uc8i9h0m	59	21	membrane	membrane	NN
cord-341968-uc8i9h0m	59	22	or	or	CC
cord-341968-uc8i9h0m	59	23	the	the	DT
cord-341968-uc8i9h0m	59	24	cell	cell	NN
cord-341968-uc8i9h0m	59	25	surface	surface	NN
cord-341968-uc8i9h0m	59	26	[	[	-LRB-
cord-341968-uc8i9h0m	59	27	22	22	CD
cord-341968-uc8i9h0m	59	28	,	,	,
cord-341968-uc8i9h0m	59	29	23	23	CD
cord-341968-uc8i9h0m	59	30	]	]	-RRB-
cord-341968-uc8i9h0m	59	31	.	.	.
cord-341968-uc8i9h0m	60	1	HPV	hpv	NN
cord-341968-uc8i9h0m	60	2	particles	particle	NNS
cord-341968-uc8i9h0m	60	3	are	be	VBP
cord-341968-uc8i9h0m	60	4	constituted	constitute	VBN
cord-341968-uc8i9h0m	60	5	by	by	IN
cord-341968-uc8i9h0m	60	6	a	a	DT
cord-341968-uc8i9h0m	60	7	naked	naked	JJ
cord-341968-uc8i9h0m	60	8	nucleocapsid	nucleocapsid	NN
cord-341968-uc8i9h0m	60	9	,	,	,
cord-341968-uc8i9h0m	60	10	and	and	CC
cord-341968-uc8i9h0m	60	11	work	work	NN
cord-341968-uc8i9h0m	60	12	done	do	VBN
cord-341968-uc8i9h0m	60	13	with	with	IN
cord-341968-uc8i9h0m	60	14	pseudovirion	pseudovirion	NN
cord-341968-uc8i9h0m	60	15	particles	particle	NNS
cord-341968-uc8i9h0m	60	16	has	have	VBZ
cord-341968-uc8i9h0m	60	17	suggested	suggest	VBN
cord-341968-uc8i9h0m	60	18	that	that	IN
cord-341968-uc8i9h0m	60	19	conformational	conformational	JJ
cord-341968-uc8i9h0m	60	20	changes	change	NNS
cord-341968-uc8i9h0m	60	21	in	in	IN
cord-341968-uc8i9h0m	60	22	the	the	DT
cord-341968-uc8i9h0m	60	23	nucleocapsid	nucleocapsid	NN
cord-341968-uc8i9h0m	60	24	proteins	protein	VBZ
cord-341968-uc8i9h0m	60	25	L1	L1	NNP
cord-341968-uc8i9h0m	60	26	and	and	CC
cord-341968-uc8i9h0m	60	27	L2	L2	NNP
cord-341968-uc8i9h0m	60	28	,	,	,
cord-341968-uc8i9h0m	60	29	that	that	WDT
cord-341968-uc8i9h0m	60	30	are	be	VBP
cord-341968-uc8i9h0m	60	31	induced	induce	VBN
cord-341968-uc8i9h0m	60	32	upon	upon	IN
cord-341968-uc8i9h0m	60	33	binding	bind	VBG
cord-341968-uc8i9h0m	60	34	of	of	IN
cord-341968-uc8i9h0m	60	35	the	the	DT
cord-341968-uc8i9h0m	60	36	virus	virus	NN
cord-341968-uc8i9h0m	60	37	to	to	IN
cord-341968-uc8i9h0m	60	38	cell	cell	NN
cord-341968-uc8i9h0m	60	39	-	-	HYPH
cord-341968-uc8i9h0m	60	40	surface	surface	NN
cord-341968-uc8i9h0m	60	41	proteoglycans	proteoglycan	NNS
cord-341968-uc8i9h0m	60	42	,	,	,
cord-341968-uc8i9h0m	60	43	prime	prime	JJ
cord-341968-uc8i9h0m	60	44	L2	l2	NN
cord-341968-uc8i9h0m	60	45	for	for	IN
cord-341968-uc8i9h0m	60	46	cleavage	cleavage	NN
cord-341968-uc8i9h0m	60	47	by	by	IN
cord-341968-uc8i9h0m	60	48	extracellular	extracellular	JJ
cord-341968-uc8i9h0m	60	49	or	or	CC
cord-341968-uc8i9h0m	60	50	pericellular	pericellular	JJ
cord-341968-uc8i9h0m	60	51	PCs	pc	NNS
cord-341968-uc8i9h0m	60	52	at	at	IN
cord-341968-uc8i9h0m	60	53	the	the	DT
cord-341968-uc8i9h0m	60	54	Arg12	Arg12	NNP
cord-341968-uc8i9h0m	60	55	residue	residue	NN
cord-341968-uc8i9h0m	60	56	[	[	-LRB-
cord-341968-uc8i9h0m	60	57	24	24	CD
cord-341968-uc8i9h0m	60	58	]	]	-RRB-
cord-341968-uc8i9h0m	60	59	.	.	.
cord-341968-uc8i9h0m	61	1	The	the	DT
cord-341968-uc8i9h0m	61	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	61	3	of	of	IN
cord-341968-uc8i9h0m	61	4	L2	l2	NN
cord-341968-uc8i9h0m	61	5	modifies	modify	VBZ
cord-341968-uc8i9h0m	61	6	the	the	DT
cord-341968-uc8i9h0m	61	7	conformation	conformation	NN
cord-341968-uc8i9h0m	61	8	of	of	IN
cord-341968-uc8i9h0m	61	9	the	the	DT
cord-341968-uc8i9h0m	61	10	coat	coat	NN
cord-341968-uc8i9h0m	61	11	proteins	protein	NNS
cord-341968-uc8i9h0m	61	12	and	and	CC
cord-341968-uc8i9h0m	61	13	allows	allow	VBZ
cord-341968-uc8i9h0m	61	14	the	the	DT
cord-341968-uc8i9h0m	61	15	virion	virion	NN
cord-341968-uc8i9h0m	61	16	to	to	TO
cord-341968-uc8i9h0m	61	17	engage	engage	VB
cord-341968-uc8i9h0m	61	18	another	another	DT
cord-341968-uc8i9h0m	61	19	receptor	receptor	NN
cord-341968-uc8i9h0m	61	20	,	,	,
cord-341968-uc8i9h0m	61	21	and	and	CC
cord-341968-uc8i9h0m	61	22	that	that	DT
cord-341968-uc8i9h0m	61	23	leads	lead	VBZ
cord-341968-uc8i9h0m	61	24	to	to	IN
cord-341968-uc8i9h0m	61	25	cell	cell	NN
cord-341968-uc8i9h0m	61	26	internalization	internalization	NN
cord-341968-uc8i9h0m	61	27	and	and	CC
cord-341968-uc8i9h0m	61	28	infection	infection	NN
cord-341968-uc8i9h0m	61	29	[	[	-LRB-
cord-341968-uc8i9h0m	61	30	25	25	CD
cord-341968-uc8i9h0m	61	31	,	,	,
cord-341968-uc8i9h0m	61	32	26	26	CD
cord-341968-uc8i9h0m	61	33	]	]	-RRB-
cord-341968-uc8i9h0m	61	34	.	.	.
cord-341968-uc8i9h0m	62	1	The	the	DT
cord-341968-uc8i9h0m	62	2	inhibition	inhibition	NN
cord-341968-uc8i9h0m	62	3	of	of	IN
cord-341968-uc8i9h0m	62	4	the	the	DT
cord-341968-uc8i9h0m	62	5	target	target	NN
cord-341968-uc8i9h0m	62	6	-	-	HYPH
cord-341968-uc8i9h0m	62	7	cell	cell	NN
cord-341968-uc8i9h0m	62	8	PCs	pc	NNS
cord-341968-uc8i9h0m	62	9	blocks	block	VBZ
cord-341968-uc8i9h0m	62	10	HPV	hpv	NN
cord-341968-uc8i9h0m	62	11	infection	infection	NN
cord-341968-uc8i9h0m	62	12	,	,	,
cord-341968-uc8i9h0m	62	13	but	but	CC
cord-341968-uc8i9h0m	62	14	the	the	DT
cord-341968-uc8i9h0m	62	15	treatment	treatment	NN
cord-341968-uc8i9h0m	62	16	of	of	IN
cord-341968-uc8i9h0m	62	17	the	the	DT
cord-341968-uc8i9h0m	62	18	pseudovirion	pseudovirion	NN
cord-341968-uc8i9h0m	62	19	particles	particle	NNS
cord-341968-uc8i9h0m	62	20	with	with	IN
cord-341968-uc8i9h0m	62	21	furin	furin	NN
cord-341968-uc8i9h0m	62	22	beforehand	beforehand	RB
cord-341968-uc8i9h0m	62	23	bypasses	bypass	VBZ
cord-341968-uc8i9h0m	62	24	the	the	DT
cord-341968-uc8i9h0m	62	25	inhibition	inhibition	NN
cord-341968-uc8i9h0m	62	26	.	.	.
cord-341968-uc8i9h0m	63	1	In	in	IN
cord-341968-uc8i9h0m	63	2	contrast	contrast	NN
cord-341968-uc8i9h0m	63	3	,	,	,
cord-341968-uc8i9h0m	63	4	the	the	DT
cord-341968-uc8i9h0m	63	5	cleavage	cleavage	NN
cord-341968-uc8i9h0m	63	6	of	of	IN
cord-341968-uc8i9h0m	63	7	live	live	JJ
cord-341968-uc8i9h0m	63	8	native	native	JJ
cord-341968-uc8i9h0m	63	9	HPV16	hpv16	NN
cord-341968-uc8i9h0m	63	10	virions	virion	NNS
cord-341968-uc8i9h0m	63	11	by	by	IN
cord-341968-uc8i9h0m	63	12	PCs	pc	NNS
cord-341968-uc8i9h0m	63	13	occurs	occur	VBZ
cord-341968-uc8i9h0m	63	14	during	during	IN
cord-341968-uc8i9h0m	63	15	virion	virion	NN
cord-341968-uc8i9h0m	63	16	morphogenesis	morphogenesis	NN
cord-341968-uc8i9h0m	63	17	,	,	,
cord-341968-uc8i9h0m	63	18	so	so	IN
cord-341968-uc8i9h0m	63	19	infectivity	infectivity	NN
cord-341968-uc8i9h0m	63	20	becomes	become	VBZ
cord-341968-uc8i9h0m	63	21	independent	independent	JJ
cord-341968-uc8i9h0m	63	22	from	from	IN
cord-341968-uc8i9h0m	63	23	the	the	DT
cord-341968-uc8i9h0m	63	24	target	target	NN
cord-341968-uc8i9h0m	63	25	-	-	HYPH
cord-341968-uc8i9h0m	63	26	cell	cell	NN
cord-341968-uc8i9h0m	63	27	PCs	pc	NNS
cord-341968-uc8i9h0m	63	28	[	[	-LRB-
cord-341968-uc8i9h0m	63	29	27	27	CD
cord-341968-uc8i9h0m	63	30	]	]	-RRB-
cord-341968-uc8i9h0m	64	1	[	[	-LRB-
cord-341968-uc8i9h0m	64	2	28	28	CD
cord-341968-uc8i9h0m	64	3	]	]	-RRB-
cord-341968-uc8i9h0m	64	4	[	[	-LRB-
cord-341968-uc8i9h0m	64	5	29	29	CD
cord-341968-uc8i9h0m	64	6	]	]	-RRB-
cord-341968-uc8i9h0m	64	7	.	.	.
cord-341968-uc8i9h0m	65	1	Also	also	RB
cord-341968-uc8i9h0m	65	2	,	,	,
cord-341968-uc8i9h0m	65	3	the	the	DT
cord-341968-uc8i9h0m	65	4	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	65	5	processing	processing	NN
cord-341968-uc8i9h0m	65	6	seems	seem	VBZ
cord-341968-uc8i9h0m	65	7	to	to	TO
cord-341968-uc8i9h0m	65	8	be	be	VB
cord-341968-uc8i9h0m	65	9	HPV	hpv	NN
cord-341968-uc8i9h0m	65	10	-	-	HYPH
cord-341968-uc8i9h0m	65	11	type	type	NN
cord-341968-uc8i9h0m	65	12	dependent	dependent	JJ
cord-341968-uc8i9h0m	65	13	,	,	,
cord-341968-uc8i9h0m	65	14	as	as	IN
cord-341968-uc8i9h0m	65	15	evidenced	evidence	VBN
cord-341968-uc8i9h0m	65	16	by	by	IN
cord-341968-uc8i9h0m	65	17	the	the	DT
cord-341968-uc8i9h0m	65	18	native	native	JJ
cord-341968-uc8i9h0m	65	19	HPV18	HPV18	NNP
cord-341968-uc8i9h0m	65	20	virions	virion	NNS
cord-341968-uc8i9h0m	65	21	being	be	VBG
cord-341968-uc8i9h0m	65	22	poorly	poorly	RB
cord-341968-uc8i9h0m	65	23	processed	process	VBN
cord-341968-uc8i9h0m	65	24	during	during	IN
cord-341968-uc8i9h0m	65	25	morphogenesis	morphogenesis	NN
cord-341968-uc8i9h0m	65	26	,	,	,
cord-341968-uc8i9h0m	65	27	and	and	CC
cord-341968-uc8i9h0m	65	28	their	-PRON-	PRP$
cord-341968-uc8i9h0m	65	29	infectivity	infectivity	NN
cord-341968-uc8i9h0m	65	30	being	be	VBG
cord-341968-uc8i9h0m	65	31	mostly	mostly	RB
cord-341968-uc8i9h0m	65	32	dependent	dependent	JJ
cord-341968-uc8i9h0m	65	33	on	on	IN
cord-341968-uc8i9h0m	65	34	the	the	DT
cord-341968-uc8i9h0m	65	35	PCs	pc	NNS
cord-341968-uc8i9h0m	65	36	of	of	IN
cord-341968-uc8i9h0m	65	37	the	the	DT
cord-341968-uc8i9h0m	65	38	target	target	NN
cord-341968-uc8i9h0m	65	39	cells	cell	NNS
cord-341968-uc8i9h0m	65	40	[	[	-LRB-
cord-341968-uc8i9h0m	65	41	27	27	CD
cord-341968-uc8i9h0m	65	42	]	]	-RRB-
cord-341968-uc8i9h0m	65	43	.	.	.
cord-341968-uc8i9h0m	66	1	L1	L1	NNP
cord-341968-uc8i9h0m	66	2	and	and	CC
cord-341968-uc8i9h0m	66	3	L2	L2	NNP
cord-341968-uc8i9h0m	66	4	in	in	IN
cord-341968-uc8i9h0m	66	5	HPV16	HPV16	NNP
cord-341968-uc8i9h0m	66	6	and	and	CC
cord-341968-uc8i9h0m	66	7	HPV18	HPV18	NNP
cord-341968-uc8i9h0m	66	8	contain	contain	VBP
cord-341968-uc8i9h0m	66	9	more	more	JJR
cord-341968-uc8i9h0m	66	10	PC	pc	NN
cord-341968-uc8i9h0m	66	11	cleavage	cleavage	NN
cord-341968-uc8i9h0m	66	12	site	site	NN
cord-341968-uc8i9h0m	66	13	motifs	motif	NNS
cord-341968-uc8i9h0m	66	14	besides	besides	IN
cord-341968-uc8i9h0m	66	15	the	the	DT
cord-341968-uc8i9h0m	66	16	commonly	commonly	RB
cord-341968-uc8i9h0m	66	17	studied	study	VBN
cord-341968-uc8i9h0m	66	18	L2-Arg12	L2-Arg12	NNP
cord-341968-uc8i9h0m	66	19	.	.	.
cord-341968-uc8i9h0m	67	1	Two	two	CD
cord-341968-uc8i9h0m	67	2	PC	pc	NN
cord-341968-uc8i9h0m	67	3	cleavage	cleavage	NN
cord-341968-uc8i9h0m	67	4	site	site	NN
cord-341968-uc8i9h0m	67	5	motifs	motif	NNS
cord-341968-uc8i9h0m	67	6	,	,	,
cord-341968-uc8i9h0m	67	7	one	one	CD
cord-341968-uc8i9h0m	67	8	at	at	IN
cord-341968-uc8i9h0m	67	9	L1-Arg74	L1-Arg74	NNP
cord-341968-uc8i9h0m	67	10	and	and	CC
cord-341968-uc8i9h0m	67	11	the	the	DT
cord-341968-uc8i9h0m	67	12	other	other	JJ
cord-341968-uc8i9h0m	67	13	at	at	IN
cord-341968-uc8i9h0m	67	14	L2-Arg305	L2-Arg305	VBN
cord-341968-uc8i9h0m	67	15	,	,	,
cord-341968-uc8i9h0m	67	16	are	be	VBP
cord-341968-uc8i9h0m	67	17	conserved	conserve	VBN
cord-341968-uc8i9h0m	67	18	in	in	IN
cord-341968-uc8i9h0m	67	19	many	many	JJ
cord-341968-uc8i9h0m	67	20	HPV	hpv	NN
cord-341968-uc8i9h0m	67	21	types	type	NNS
cord-341968-uc8i9h0m	67	22	(	(	-LRB-
cord-341968-uc8i9h0m	67	23	Table	table	NN
cord-341968-uc8i9h0m	67	24	2	2	CD
cord-341968-uc8i9h0m	67	25	)	)	-RRB-
cord-341968-uc8i9h0m	67	26	.	.	.
cord-341968-uc8i9h0m	68	1	Mutagenesis	Mutagenesis	NNP
cord-341968-uc8i9h0m	68	2	of	of	IN
cord-341968-uc8i9h0m	68	3	the	the	DT
cord-341968-uc8i9h0m	68	4	L1-Arg74	L1-Arg74	NNP
cord-341968-uc8i9h0m	68	5	site	site	NN
cord-341968-uc8i9h0m	68	6	has	have	VBZ
cord-341968-uc8i9h0m	68	7	been	be	VBN
cord-341968-uc8i9h0m	68	8	reported	report	VBN
cord-341968-uc8i9h0m	68	9	to	to	TO
cord-341968-uc8i9h0m	68	10	affect	affect	VB
cord-341968-uc8i9h0m	68	11	pseudovirion	pseudovirion	NN
cord-341968-uc8i9h0m	68	12	morphogenesis	morphogenesis	NN
cord-341968-uc8i9h0m	68	13	[	[	-LRB-
cord-341968-uc8i9h0m	68	14	30	30	CD
cord-341968-uc8i9h0m	68	15	]	]	-RRB-
cord-341968-uc8i9h0m	68	16	.	.	.
cord-341968-uc8i9h0m	69	1	The	the	DT
cord-341968-uc8i9h0m	69	2	L2-Arg305	l2-arg305	JJ
cord-341968-uc8i9h0m	69	3	site	site	NN
cord-341968-uc8i9h0m	69	4	is	be	VBZ
cord-341968-uc8i9h0m	69	5	located	locate	VBN
cord-341968-uc8i9h0m	69	6	in	in	IN
cord-341968-uc8i9h0m	69	7	a	a	DT
cord-341968-uc8i9h0m	69	8	region	region	NN
cord-341968-uc8i9h0m	69	9	of	of	IN
cord-341968-uc8i9h0m	69	10	L2	l2	NN
cord-341968-uc8i9h0m	69	11	involved	involve	VBN
cord-341968-uc8i9h0m	69	12	in	in	IN
cord-341968-uc8i9h0m	69	13	the	the	DT
cord-341968-uc8i9h0m	69	14	regulation	regulation	NN
cord-341968-uc8i9h0m	69	15	of	of	IN
cord-341968-uc8i9h0m	69	16	retrograde	retrograde	JJ
cord-341968-uc8i9h0m	69	17	trafficking	trafficking	NN
cord-341968-uc8i9h0m	69	18	of	of	IN
cord-341968-uc8i9h0m	69	19	the	the	DT
cord-341968-uc8i9h0m	69	20	L2-viral	l2-viral	JJ
cord-341968-uc8i9h0m	69	21	genome	genome	NN
cord-341968-uc8i9h0m	69	22	complex	complex	NN
cord-341968-uc8i9h0m	69	23	from	from	IN
cord-341968-uc8i9h0m	69	24	the	the	DT
cord-341968-uc8i9h0m	69	25	trans	trans	NNP
cord-341968-uc8i9h0m	69	26	-	-	NNP
cord-341968-uc8i9h0m	69	27	Golgi	Golgi	NNP
cord-341968-uc8i9h0m	69	28	network	network	NN
cord-341968-uc8i9h0m	69	29	and	and	CC
cord-341968-uc8i9h0m	69	30	into	into	IN
cord-341968-uc8i9h0m	69	31	the	the	DT
cord-341968-uc8i9h0m	69	32	nucleus	nucleus	NN
cord-341968-uc8i9h0m	69	33	[	[	-LRB-
cord-341968-uc8i9h0m	69	34	31	31	CD
cord-341968-uc8i9h0m	69	35	,	,	,
cord-341968-uc8i9h0m	69	36	32	32	CD
cord-341968-uc8i9h0m	69	37	]	]	-RRB-
cord-341968-uc8i9h0m	69	38	.	.	.
cord-341968-uc8i9h0m	70	1	Surprisingly	surprisingly	RB
cord-341968-uc8i9h0m	70	2	,	,	,
cord-341968-uc8i9h0m	70	3	low	low	JJ
cord-341968-uc8i9h0m	70	4	-	-	HYPH
cord-341968-uc8i9h0m	70	5	risk	risk	NN
cord-341968-uc8i9h0m	70	6	HPV	hpv	NN
cord-341968-uc8i9h0m	70	7	types	type	NNS
cord-341968-uc8i9h0m	70	8	have	have	VBP
cord-341968-uc8i9h0m	70	9	Lys	Lys	NNP
cord-341968-uc8i9h0m	70	10	at	at	IN
cord-341968-uc8i9h0m	70	11	the	the	DT
cord-341968-uc8i9h0m	70	12	L1	L1	NNP
cord-341968-uc8i9h0m	70	13	-	-	HYPH
cord-341968-uc8i9h0m	70	14	74	74	CD
cord-341968-uc8i9h0m	70	15	position	position	NN
cord-341968-uc8i9h0m	70	16	instead	instead	RB
cord-341968-uc8i9h0m	70	17	of	of	IN
cord-341968-uc8i9h0m	70	18	the	the	DT
cord-341968-uc8i9h0m	70	19	Arg	arg	NN
cord-341968-uc8i9h0m	70	20	of	of	IN
cord-341968-uc8i9h0m	70	21	high	high	JJ
cord-341968-uc8i9h0m	70	22	-	-	HYPH
cord-341968-uc8i9h0m	70	23	risk	risk	NN
cord-341968-uc8i9h0m	70	24	types	type	NNS
cord-341968-uc8i9h0m	70	25	(	(	-LRB-
cord-341968-uc8i9h0m	70	26	Table	table	NN
cord-341968-uc8i9h0m	70	27	2	2	CD
cord-341968-uc8i9h0m	70	28	)	)	-RRB-
cord-341968-uc8i9h0m	70	29	.	.	.
cord-341968-uc8i9h0m	71	1	If	if	IN
cord-341968-uc8i9h0m	71	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	71	3	at	at	IN
cord-341968-uc8i9h0m	71	4	the	the	DT
cord-341968-uc8i9h0m	71	5	L1	L1	NNP
cord-341968-uc8i9h0m	71	6	-	-	HYPH
cord-341968-uc8i9h0m	71	7	74	74	CD
cord-341968-uc8i9h0m	71	8	site	site	NN
cord-341968-uc8i9h0m	71	9	is	be	VBZ
cord-341968-uc8i9h0m	71	10	required	require	VBN
cord-341968-uc8i9h0m	71	11	for	for	IN
cord-341968-uc8i9h0m	71	12	virus	virus	NN
cord-341968-uc8i9h0m	71	13	morphogenesis	morphogenesis	NN
cord-341968-uc8i9h0m	71	14	,	,	,
cord-341968-uc8i9h0m	71	15	lowand	lowand	VB
cord-341968-uc8i9h0m	71	16	high	high	JJ
cord-341968-uc8i9h0m	71	17	-	-	HYPH
cord-341968-uc8i9h0m	71	18	risk	risk	NN
cord-341968-uc8i9h0m	71	19	types	type	NNS
cord-341968-uc8i9h0m	71	20	may	may	MD
cord-341968-uc8i9h0m	71	21	use	use	VB
cord-341968-uc8i9h0m	71	22	different	different	JJ
cord-341968-uc8i9h0m	71	23	proteases	protease	NNS
cord-341968-uc8i9h0m	71	24	,	,	,
cord-341968-uc8i9h0m	71	25	unless	unless	IN
cord-341968-uc8i9h0m	71	26	their	-PRON-	PRP$
cord-341968-uc8i9h0m	71	27	morphogenesis	morphogenesis	NN
cord-341968-uc8i9h0m	71	28	is	be	VBZ
cord-341968-uc8i9h0m	71	29	different	different	JJ
cord-341968-uc8i9h0m	71	30	.	.	.
cord-341968-uc8i9h0m	72	1	If	if	IN
cord-341968-uc8i9h0m	72	2	the	the	DT
cord-341968-uc8i9h0m	72	3	cleavage	cleavage	NN
cord-341968-uc8i9h0m	72	4	at	at	IN
cord-341968-uc8i9h0m	72	5	the	the	DT
cord-341968-uc8i9h0m	72	6	L1-Arg74	L1-Arg74	NNP
cord-341968-uc8i9h0m	72	7	and	and	CC
cord-341968-uc8i9h0m	72	8	L2-Arg305	L2-Arg305	VBN
cord-341968-uc8i9h0m	72	9	sites	site	NNS
cord-341968-uc8i9h0m	72	10	takes	take	VBZ
cord-341968-uc8i9h0m	72	11	place	place	NN
cord-341968-uc8i9h0m	72	12	during	during	IN
cord-341968-uc8i9h0m	72	13	cell	cell	NN
cord-341968-uc8i9h0m	72	14	entry	entry	NN
cord-341968-uc8i9h0m	72	15	,	,	,
cord-341968-uc8i9h0m	72	16	the	the	DT
cord-341968-uc8i9h0m	72	17	cleavage	cleavage	NN
cord-341968-uc8i9h0m	72	18	sites	site	NNS
cord-341968-uc8i9h0m	72	19	may	may	MD
cord-341968-uc8i9h0m	72	20	be	be	VB
cord-341968-uc8i9h0m	72	21	hidden	hide	VBN
cord-341968-uc8i9h0m	72	22	inside	inside	IN
cord-341968-uc8i9h0m	72	23	the	the	DT
cord-341968-uc8i9h0m	72	24	folded	fold	VBN
cord-341968-uc8i9h0m	72	25	protein	protein	NN
cord-341968-uc8i9h0m	72	26	and	and	CC
cord-341968-uc8i9h0m	72	27	protected	protect	VBN
cord-341968-uc8i9h0m	72	28	from	from	IN
cord-341968-uc8i9h0m	72	29	being	be	VBG
cord-341968-uc8i9h0m	72	30	accessed	access	VBN
cord-341968-uc8i9h0m	72	31	by	by	IN
cord-341968-uc8i9h0m	72	32	the	the	DT
cord-341968-uc8i9h0m	72	33	PCs	pc	NNS
cord-341968-uc8i9h0m	72	34	in	in	IN
cord-341968-uc8i9h0m	72	35	the	the	DT
cord-341968-uc8i9h0m	72	36	intact	intact	JJ
cord-341968-uc8i9h0m	72	37	virion	virion	NN
cord-341968-uc8i9h0m	72	38	.	.	.
cord-341968-uc8i9h0m	73	1	However	however	RB
cord-341968-uc8i9h0m	73	2	,	,	,
cord-341968-uc8i9h0m	73	3	the	the	DT
cord-341968-uc8i9h0m	73	4	virions	virion	NNS
cord-341968-uc8i9h0m	73	5	undergo	undergo	VBP
cord-341968-uc8i9h0m	73	6	controlled	control	VBN
cord-341968-uc8i9h0m	73	7	unfolding	unfold	VBG
cord-341968-uc8i9h0m	73	8	during	during	IN
cord-341968-uc8i9h0m	73	9	entry	entry	NN
cord-341968-uc8i9h0m	73	10	and	and	CC
cord-341968-uc8i9h0m	73	11	trafficking	trafficking	NN
cord-341968-uc8i9h0m	73	12	,	,	,
cord-341968-uc8i9h0m	73	13	so	so	IN
cord-341968-uc8i9h0m	73	14	that	that	IN
cord-341968-uc8i9h0m	73	15	the	the	DT
cord-341968-uc8i9h0m	73	16	PC	pc	NN
cord-341968-uc8i9h0m	73	17	cleavage	cleavage	NN
cord-341968-uc8i9h0m	73	18	sites	site	NNS
cord-341968-uc8i9h0m	73	19	may	may	MD
cord-341968-uc8i9h0m	73	20	become	become	VB
cord-341968-uc8i9h0m	73	21	exposed	expose	VBN
cord-341968-uc8i9h0m	73	22	and	and	CC
cord-341968-uc8i9h0m	73	23	cleaved	cleave	VBN
cord-341968-uc8i9h0m	73	24	along	along	IN
cord-341968-uc8i9h0m	73	25	their	-PRON-	PRP$
cord-341968-uc8i9h0m	73	26	cell	cell	NN
cord-341968-uc8i9h0m	73	27	internalization	internalization	NN
cord-341968-uc8i9h0m	73	28	route	route	NN
cord-341968-uc8i9h0m	73	29	.	.	.
cord-341968-uc8i9h0m	74	1	The	the	DT
cord-341968-uc8i9h0m	74	2	potential	potential	JJ
cord-341968-uc8i9h0m	74	3	diverse	diverse	JJ
cord-341968-uc8i9h0m	74	4	expression	expression	NN
cord-341968-uc8i9h0m	74	5	of	of	IN
cord-341968-uc8i9h0m	74	6	the	the	DT
cord-341968-uc8i9h0m	74	7	PC	pc	NN
cord-341968-uc8i9h0m	74	8	genes	gene	NNS
cord-341968-uc8i9h0m	74	9	in	in	IN
cord-341968-uc8i9h0m	74	10	keratinocytes	keratinocyte	NNS
cord-341968-uc8i9h0m	74	11	at	at	IN
cord-341968-uc8i9h0m	74	12	different	different	JJ
cord-341968-uc8i9h0m	74	13	anatomical	anatomical	JJ
cord-341968-uc8i9h0m	74	14	sites	site	NNS
cord-341968-uc8i9h0m	74	15	of	of	IN
cord-341968-uc8i9h0m	74	16	HPV	hpv	NN
cord-341968-uc8i9h0m	74	17	infection	infection	NN
cord-341968-uc8i9h0m	74	18	may	may	MD
cord-341968-uc8i9h0m	74	19	contribute	contribute	VB
cord-341968-uc8i9h0m	74	20	to	to	IN
cord-341968-uc8i9h0m	74	21	the	the	DT
cord-341968-uc8i9h0m	74	22	restricted	restricted	JJ
cord-341968-uc8i9h0m	74	23	cell	cell	NN
cord-341968-uc8i9h0m	74	24	tropism	tropism	NN
cord-341968-uc8i9h0m	74	25	by	by	IN
cord-341968-uc8i9h0m	74	26	HPV	hpv	NN
cord-341968-uc8i9h0m	74	27	types	type	NNS
cord-341968-uc8i9h0m	74	28	,	,	,
cord-341968-uc8i9h0m	74	29	which	which	WDT
cord-341968-uc8i9h0m	74	30	is	be	VBZ
cord-341968-uc8i9h0m	74	31	especially	especially	RB
cord-341968-uc8i9h0m	74	32	different	different	JJ
cord-341968-uc8i9h0m	74	33	between	between	IN
cord-341968-uc8i9h0m	74	34	the	the	DT
cord-341968-uc8i9h0m	74	35	skin	skin	NN
cord-341968-uc8i9h0m	74	36	and	and	CC
cord-341968-uc8i9h0m	74	37	mucosal	mucosal	JJ
cord-341968-uc8i9h0m	74	38	types	type	NNS
cord-341968-uc8i9h0m	74	39	[	[	-LRB-
cord-341968-uc8i9h0m	74	40	33	33	CD
cord-341968-uc8i9h0m	74	41	]	]	-RRB-
cord-341968-uc8i9h0m	74	42	.	.	.
cord-341968-uc8i9h0m	75	1	HPV16	hpv16	NN
cord-341968-uc8i9h0m	75	2	is	be	VBZ
cord-341968-uc8i9h0m	75	3	commonly	commonly	RB
cord-341968-uc8i9h0m	75	4	found	find	VBN
cord-341968-uc8i9h0m	75	5	in	in	IN
cord-341968-uc8i9h0m	75	6	the	the	DT
cord-341968-uc8i9h0m	75	7	stratified	stratified	JJ
cord-341968-uc8i9h0m	75	8	epithelium	epithelium	NN
cord-341968-uc8i9h0m	75	9	of	of	IN
cord-341968-uc8i9h0m	75	10	the	the	DT
cord-341968-uc8i9h0m	75	11	ectocervix	ectocervix	NN
cord-341968-uc8i9h0m	75	12	and	and	CC
cord-341968-uc8i9h0m	75	13	tonsilar	tonsilar	NNP
cord-341968-uc8i9h0m	75	14	crypts	crypt	NNS
cord-341968-uc8i9h0m	75	15	,	,	,
cord-341968-uc8i9h0m	75	16	and	and	CC
cord-341968-uc8i9h0m	75	17	HPV18	HPV18	NNP
cord-341968-uc8i9h0m	75	18	is	be	VBZ
cord-341968-uc8i9h0m	75	19	mainly	mainly	RB
cord-341968-uc8i9h0m	75	20	found	find	VBN
cord-341968-uc8i9h0m	75	21	in	in	IN
cord-341968-uc8i9h0m	75	22	the	the	DT
cord-341968-uc8i9h0m	75	23	glandular	glandular	JJ
cord-341968-uc8i9h0m	75	24	epithelium	epithelium	NN
cord-341968-uc8i9h0m	75	25	of	of	IN
cord-341968-uc8i9h0m	75	26	the	the	DT
cord-341968-uc8i9h0m	75	27	endocervix	endocervix	NN
cord-341968-uc8i9h0m	75	28	.	.	.
cord-341968-uc8i9h0m	76	1	Their	-PRON-	PRP$
cord-341968-uc8i9h0m	76	2	differences	difference	NNS
cord-341968-uc8i9h0m	76	3	in	in	IN
cord-341968-uc8i9h0m	76	4	PC	pc	NN
cord-341968-uc8i9h0m	76	5	reactivity	reactivity	NN
cord-341968-uc8i9h0m	76	6	may	may	MD
cord-341968-uc8i9h0m	76	7	play	play	VB
cord-341968-uc8i9h0m	76	8	a	a	DT
cord-341968-uc8i9h0m	76	9	role	role	NN
cord-341968-uc8i9h0m	76	10	in	in	IN
cord-341968-uc8i9h0m	76	11	determining	determine	VBG
cord-341968-uc8i9h0m	76	12	their	-PRON-	PRP$
cord-341968-uc8i9h0m	76	13	particular	particular	JJ
cord-341968-uc8i9h0m	76	14	tropism	tropism	NN
cord-341968-uc8i9h0m	76	15	.	.	.
cord-341968-uc8i9h0m	77	1	Table	table	NN
cord-341968-uc8i9h0m	77	2	2	2	CD
cord-341968-uc8i9h0m	77	3	.	.	.
cord-341968-uc8i9h0m	78	1	PC	pc	NN
cord-341968-uc8i9h0m	78	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	78	3	site	site	NN
cord-341968-uc8i9h0m	78	4	motifs	motif	NNS
cord-341968-uc8i9h0m	78	5	in	in	IN
cord-341968-uc8i9h0m	78	6	the	the	DT
cord-341968-uc8i9h0m	78	7	coat	coat	NN
cord-341968-uc8i9h0m	78	8	proteins	protein	VBZ
cord-341968-uc8i9h0m	78	9	L1	L1	NNP
cord-341968-uc8i9h0m	78	10	and	and	CC
cord-341968-uc8i9h0m	78	11	L2	L2	NNP
cord-341968-uc8i9h0m	78	12	of	of	IN
cord-341968-uc8i9h0m	78	13	HPV	HPV	NNP
cord-341968-uc8i9h0m	78	14	types	type	NNS
cord-341968-uc8i9h0m	78	15	.	.	.
cord-341968-uc8i9h0m	79	1	The	the	DT
cord-341968-uc8i9h0m	79	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	79	3	site	site	NN
cord-341968-uc8i9h0m	79	4	numbers	number	NNS
cord-341968-uc8i9h0m	79	5	correspond	correspond	VBP
cord-341968-uc8i9h0m	79	6	to	to	IN
cord-341968-uc8i9h0m	79	7	those	those	DT
cord-341968-uc8i9h0m	79	8	in	in	IN
cord-341968-uc8i9h0m	79	9	the	the	DT
cord-341968-uc8i9h0m	79	10	HPV16	hpv16	NN
cord-341968-uc8i9h0m	79	11	sequences	sequence	NNS
cord-341968-uc8i9h0m	79	12	.	.	.
cord-341968-uc8i9h0m	80	1	The	the	DT
cord-341968-uc8i9h0m	80	2	P4Arg	P4Arg	NNP
cord-341968-uc8i9h0m	80	3	and	and	CC
cord-341968-uc8i9h0m	80	4	P1Arg	p1arg	NN
cord-341968-uc8i9h0m	80	5	residues	residue	NNS
cord-341968-uc8i9h0m	80	6	are	be	VBP
cord-341968-uc8i9h0m	80	7	denoted	denote	VBN
cord-341968-uc8i9h0m	80	8	in	in	IN
cord-341968-uc8i9h0m	80	9	red	red	NN
cord-341968-uc8i9h0m	80	10	.	.	.
cord-341968-uc8i9h0m	81	1	The	the	DT
cord-341968-uc8i9h0m	81	2	envelope	envelope	NN
cord-341968-uc8i9h0m	81	3	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	81	4	B	B	NNP
cord-341968-uc8i9h0m	81	5	(	(	-LRB-
cord-341968-uc8i9h0m	81	6	gB	gB	NNP
cord-341968-uc8i9h0m	81	7	)	)	-RRB-
cord-341968-uc8i9h0m	81	8	is	be	VBZ
cord-341968-uc8i9h0m	81	9	the	the	DT
cord-341968-uc8i9h0m	81	10	most	most	RBS
cord-341968-uc8i9h0m	81	11	conserved	conserved	JJ
cord-341968-uc8i9h0m	81	12	protein	protein	NN
cord-341968-uc8i9h0m	81	13	among	among	IN
cord-341968-uc8i9h0m	81	14	all	all	DT
cord-341968-uc8i9h0m	81	15	herpes	herpes	NN
cord-341968-uc8i9h0m	81	16	viruses	virus	NNS
cord-341968-uc8i9h0m	81	17	,	,	,
cord-341968-uc8i9h0m	81	18	and	and	CC
cord-341968-uc8i9h0m	81	19	its	-PRON-	PRP$
cord-341968-uc8i9h0m	81	20	function	function	NN
cord-341968-uc8i9h0m	81	21	is	be	VBZ
cord-341968-uc8i9h0m	81	22	to	to	TO
cord-341968-uc8i9h0m	81	23	regulate	regulate	VB
cord-341968-uc8i9h0m	81	24	virus	virus	NN
cord-341968-uc8i9h0m	81	25	to	to	IN
cord-341968-uc8i9h0m	81	26	cell	cell	NN
cord-341968-uc8i9h0m	81	27	membrane	membrane	NN
cord-341968-uc8i9h0m	81	28	fusion	fusion	NN
cord-341968-uc8i9h0m	81	29	.	.	.
cord-341968-uc8i9h0m	82	1	gB	gB	NNP
cord-341968-uc8i9h0m	82	2	is	be	VBZ
cord-341968-uc8i9h0m	82	3	synthesized	synthesize	VBN
cord-341968-uc8i9h0m	82	4	as	as	IN
cord-341968-uc8i9h0m	82	5	a	a	DT
cord-341968-uc8i9h0m	82	6	precursor	precursor	NN
cord-341968-uc8i9h0m	82	7	protein	protein	NN
cord-341968-uc8i9h0m	82	8	,	,	,
cord-341968-uc8i9h0m	82	9	and	and	CC
cord-341968-uc8i9h0m	82	10	PCs	pc	NNS
cord-341968-uc8i9h0m	82	11	cleave	cleave	VBP
cord-341968-uc8i9h0m	82	12	it	-PRON-	PRP
cord-341968-uc8i9h0m	82	13	at	at	IN
cord-341968-uc8i9h0m	82	14	a	a	DT
cord-341968-uc8i9h0m	82	15	loop	loop	NN
cord-341968-uc8i9h0m	82	16	,	,	,
cord-341968-uc8i9h0m	82	17	which	which	WDT
cord-341968-uc8i9h0m	82	18	is	be	VBZ
cord-341968-uc8i9h0m	82	19	located	locate	VBN
cord-341968-uc8i9h0m	82	20	in	in	IN
cord-341968-uc8i9h0m	82	21	domain	domain	NN
cord-341968-uc8i9h0m	82	22	II	ii	CD
cord-341968-uc8i9h0m	82	23	of	of	IN
cord-341968-uc8i9h0m	82	24	the	the	DT
cord-341968-uc8i9h0m	82	25	ectodomain	ectodomain	NN
cord-341968-uc8i9h0m	82	26	and	and	CC
cord-341968-uc8i9h0m	82	27	at	at	IN
cord-341968-uc8i9h0m	82	28	a	a	DT
cord-341968-uc8i9h0m	82	29	distance	distance	NN
cord-341968-uc8i9h0m	82	30	from	from	IN
cord-341968-uc8i9h0m	82	31	the	the	DT
cord-341968-uc8i9h0m	82	32	fusion	fusion	NN
cord-341968-uc8i9h0m	82	33	loop	loop	NN
cord-341968-uc8i9h0m	82	34	at	at	IN
cord-341968-uc8i9h0m	82	35	domain	domain	NN
cord-341968-uc8i9h0m	82	36	I.	i.	NN
cord-341968-uc8i9h0m	83	1	The	the	DT
cord-341968-uc8i9h0m	83	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	83	3	site	site	NN
cord-341968-uc8i9h0m	83	4	loop	loop	NN
cord-341968-uc8i9h0m	83	5	is	be	VBZ
cord-341968-uc8i9h0m	83	6	highly	highly	RB
cord-341968-uc8i9h0m	83	7	variable	variable	JJ
cord-341968-uc8i9h0m	83	8	in	in	IN
cord-341968-uc8i9h0m	83	9	length	length	NN
cord-341968-uc8i9h0m	83	10	and	and	CC
cord-341968-uc8i9h0m	83	11	amino	amino	NN
cord-341968-uc8i9h0m	83	12	acid	acid	NN
cord-341968-uc8i9h0m	83	13	sequence	sequence	NN
cord-341968-uc8i9h0m	83	14	among	among	IN
cord-341968-uc8i9h0m	83	15	herpes	herpes	NN
cord-341968-uc8i9h0m	83	16	viruses	virus	NNS
cord-341968-uc8i9h0m	83	17	(	(	-LRB-
cord-341968-uc8i9h0m	83	18	Table	table	NN
cord-341968-uc8i9h0m	83	19	3	3	CD
cord-341968-uc8i9h0m	83	20	)	)	-RRB-
cord-341968-uc8i9h0m	83	21	.	.	.
cord-341968-uc8i9h0m	84	1	The	the	DT
cord-341968-uc8i9h0m	84	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	84	3	of	of	IN
cord-341968-uc8i9h0m	84	4	gB	gB	NNP
cord-341968-uc8i9h0m	84	5	by	by	IN
cord-341968-uc8i9h0m	84	6	PCs	pc	NNS
cord-341968-uc8i9h0m	84	7	has	have	VBZ
cord-341968-uc8i9h0m	84	8	been	be	VBN
cord-341968-uc8i9h0m	84	9	demonstrated	demonstrate	VBN
cord-341968-uc8i9h0m	84	10	[	[	-LRB-
cord-341968-uc8i9h0m	84	11	34	34	CD
cord-341968-uc8i9h0m	84	12	]	]	-RRB-
cord-341968-uc8i9h0m	84	13	.	.	.
cord-341968-uc8i9h0m	85	1	Most	Most	JJS
cord-341968-uc8i9h0m	85	2	herpes	herpes	NN
cord-341968-uc8i9h0m	85	3	viruses	virus	NNS
cord-341968-uc8i9h0m	85	4	have	have	VBP
cord-341968-uc8i9h0m	85	5	at	at	RB
cord-341968-uc8i9h0m	85	6	least	least	RBS
cord-341968-uc8i9h0m	85	7	one	one	CD
cord-341968-uc8i9h0m	85	8	PC	pc	NN
cord-341968-uc8i9h0m	85	9	cleavage	cleavage	NN
cord-341968-uc8i9h0m	85	10	site	site	NN
cord-341968-uc8i9h0m	85	11	motif	motif	NN
cord-341968-uc8i9h0m	85	12	in	in	IN
cord-341968-uc8i9h0m	85	13	the	the	DT
cord-341968-uc8i9h0m	85	14	cleavage	cleavage	NN
cord-341968-uc8i9h0m	85	15	loop	loop	NN
cord-341968-uc8i9h0m	85	16	,	,	,
cord-341968-uc8i9h0m	85	17	although	although	RB
cord-341968-uc8i9h0m	85	18	,	,	,
cord-341968-uc8i9h0m	85	19	HHSV1	HHSV1	NNP
cord-341968-uc8i9h0m	85	20	is	be	VBZ
cord-341968-uc8i9h0m	85	21	an	an	DT
cord-341968-uc8i9h0m	85	22	exception	exception	NN
cord-341968-uc8i9h0m	85	23	by	by	IN
cord-341968-uc8i9h0m	85	24	having	have	VBG
cord-341968-uc8i9h0m	85	25	no	no	DT
cord-341968-uc8i9h0m	85	26	PC	pc	NN
cord-341968-uc8i9h0m	85	27	motifs	motif	NNS
cord-341968-uc8i9h0m	85	28	at	at	RB
cord-341968-uc8i9h0m	85	29	all	all	RB
cord-341968-uc8i9h0m	85	30	.	.	.
cord-341968-uc8i9h0m	86	1	In	in	IN
cord-341968-uc8i9h0m	86	2	contrast	contrast	NN
cord-341968-uc8i9h0m	86	3	,	,	,
cord-341968-uc8i9h0m	86	4	other	other	JJ
cord-341968-uc8i9h0m	86	5	viruses	virus	NNS
cord-341968-uc8i9h0m	86	6	have	have	VBP
cord-341968-uc8i9h0m	86	7	more	more	JJR
cord-341968-uc8i9h0m	86	8	than	than	IN
cord-341968-uc8i9h0m	86	9	one	one	CD
cord-341968-uc8i9h0m	86	10	PC	pc	NN
cord-341968-uc8i9h0m	86	11	cleavage	cleavage	NN
cord-341968-uc8i9h0m	86	12	site	site	NN
cord-341968-uc8i9h0m	86	13	,	,	,
cord-341968-uc8i9h0m	86	14	which	which	WDT
cord-341968-uc8i9h0m	86	15	may	may	MD
cord-341968-uc8i9h0m	86	16	be	be	VB
cord-341968-uc8i9h0m	86	17	cleaved	cleave	VBN
cord-341968-uc8i9h0m	86	18	sequentially	sequentially	RB
cord-341968-uc8i9h0m	86	19	[	[	-LRB-
cord-341968-uc8i9h0m	86	20	35	35	CD
cord-341968-uc8i9h0m	86	21	]	]	-RRB-
cord-341968-uc8i9h0m	86	22	.	.	.
cord-341968-uc8i9h0m	87	1	The	the	DT
cord-341968-uc8i9h0m	87	2	experimental	experimental	JJ
cord-341968-uc8i9h0m	87	3	inactivation	inactivation	NN
cord-341968-uc8i9h0m	87	4	of	of	IN
cord-341968-uc8i9h0m	87	5	the	the	DT
cord-341968-uc8i9h0m	87	6	PC	pc	NN
cord-341968-uc8i9h0m	87	7	cleavage	cleavage	NN
cord-341968-uc8i9h0m	87	8	site	site	NN
cord-341968-uc8i9h0m	87	9	of	of	IN
cord-341968-uc8i9h0m	87	10	several	several	JJ
cord-341968-uc8i9h0m	87	11	herpes	herpes	NN
cord-341968-uc8i9h0m	87	12	viruses	virus	NNS
cord-341968-uc8i9h0m	87	13	did	do	VBD
cord-341968-uc8i9h0m	87	14	not	not	RB
cord-341968-uc8i9h0m	87	15	severely	severely	RB
cord-341968-uc8i9h0m	87	16	affect	affect	VB
cord-341968-uc8i9h0m	87	17	viral	viral	JJ
cord-341968-uc8i9h0m	87	18	cell	cell	NN
cord-341968-uc8i9h0m	87	19	entry	entry	NN
cord-341968-uc8i9h0m	87	20	into	into	IN
cord-341968-uc8i9h0m	87	21	cells	cell	NNS
cord-341968-uc8i9h0m	87	22	growing	grow	VBG
cord-341968-uc8i9h0m	87	23	in	in	IN
cord-341968-uc8i9h0m	87	24	vitro	vitro	FW
cord-341968-uc8i9h0m	87	25	;	;	:
cord-341968-uc8i9h0m	87	26	however	however	RB
cord-341968-uc8i9h0m	87	27	,	,	,
cord-341968-uc8i9h0m	87	28	the	the	DT
cord-341968-uc8i9h0m	87	29	lack	lack	NN
cord-341968-uc8i9h0m	87	30	of	of	IN
cord-341968-uc8i9h0m	87	31	PC	pc	NN
cord-341968-uc8i9h0m	87	32	cleavage	cleavage	NN
cord-341968-uc8i9h0m	87	33	reduced	reduce	VBN
cord-341968-uc8i9h0m	87	34	virus	virus	NN
cord-341968-uc8i9h0m	87	35	spread	spread	NN
cord-341968-uc8i9h0m	87	36	and	and	CC
cord-341968-uc8i9h0m	87	37	replication	replication	NN
cord-341968-uc8i9h0m	87	38	in	in	IN
cord-341968-uc8i9h0m	87	39	vivo	vivo	NNP
cord-341968-uc8i9h0m	87	40	[	[	-LRB-
cord-341968-uc8i9h0m	87	41	36	36	CD
cord-341968-uc8i9h0m	87	42	,	,	,
cord-341968-uc8i9h0m	87	43	37	37	CD
cord-341968-uc8i9h0m	87	44	]	]	-RRB-
cord-341968-uc8i9h0m	87	45	.	.	.
cord-341968-uc8i9h0m	88	1	The	the	DT
cord-341968-uc8i9h0m	88	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	88	3	of	of	IN
cord-341968-uc8i9h0m	88	4	gB	gB	NNP
cord-341968-uc8i9h0m	88	5	promotes	promote	VBZ
cord-341968-uc8i9h0m	88	6	virus	virus	NN
cord-341968-uc8i9h0m	88	7	-	-	HYPH
cord-341968-uc8i9h0m	88	8	to	to	IN
cord-341968-uc8i9h0m	88	9	-	-	HYPH
cord-341968-uc8i9h0m	88	10	cell	cell	NN
cord-341968-uc8i9h0m	88	11	and	and	CC
cord-341968-uc8i9h0m	88	12	cell	cell	NN
cord-341968-uc8i9h0m	88	13	-	-	HYPH
cord-341968-uc8i9h0m	88	14	to	to	IN
cord-341968-uc8i9h0m	88	15	-	-	HYPH
cord-341968-uc8i9h0m	88	16	cell	cell	NN
cord-341968-uc8i9h0m	88	17	fusion	fusion	NN
cord-341968-uc8i9h0m	88	18	[	[	-LRB-
cord-341968-uc8i9h0m	88	19	36	36	CD
cord-341968-uc8i9h0m	88	20	,	,	,
cord-341968-uc8i9h0m	88	21	38	38	CD
cord-341968-uc8i9h0m	88	22	]	]	-RRB-
cord-341968-uc8i9h0m	88	23	.	.	.
cord-341968-uc8i9h0m	89	1	Although	although	IN
cord-341968-uc8i9h0m	89	2	much	much	JJ
cord-341968-uc8i9h0m	89	3	is	be	VBZ
cord-341968-uc8i9h0m	89	4	still	still	RB
cord-341968-uc8i9h0m	89	5	needed	need	VBN
cord-341968-uc8i9h0m	89	6	to	to	TO
cord-341968-uc8i9h0m	89	7	consolidate	consolidate	VB
cord-341968-uc8i9h0m	89	8	our	-PRON-	PRP$
cord-341968-uc8i9h0m	89	9	knowledge	knowledge	NN
cord-341968-uc8i9h0m	89	10	of	of	IN
cord-341968-uc8i9h0m	89	11	the	the	DT
cord-341968-uc8i9h0m	89	12	cleavage	cleavage	NN
cord-341968-uc8i9h0m	89	13	of	of	IN
cord-341968-uc8i9h0m	89	14	gB	gB	NNP
cord-341968-uc8i9h0m	89	15	by	by	IN
cord-341968-uc8i9h0m	89	16	PCs	pc	NNS
cord-341968-uc8i9h0m	89	17	,	,	,
cord-341968-uc8i9h0m	89	18	there	there	EX
cord-341968-uc8i9h0m	89	19	is	be	VBZ
cord-341968-uc8i9h0m	89	20	no	no	DT
cord-341968-uc8i9h0m	89	21	doubt	doubt	NN
cord-341968-uc8i9h0m	89	22	that	that	IN
cord-341968-uc8i9h0m	89	23	the	the	DT
cord-341968-uc8i9h0m	89	24	presence	presence	NN
cord-341968-uc8i9h0m	89	25	of	of	IN
cord-341968-uc8i9h0m	89	26	PC	pc	NN
cord-341968-uc8i9h0m	89	27	cleavage	cleavage	NN
cord-341968-uc8i9h0m	89	28	site	site	NN
cord-341968-uc8i9h0m	89	29	motifs	motif	NNS
cord-341968-uc8i9h0m	89	30	in	in	IN
cord-341968-uc8i9h0m	89	31	gB	gB	NNP
cord-341968-uc8i9h0m	89	32	is	be	VBZ
cord-341968-uc8i9h0m	89	33	the	the	DT
cord-341968-uc8i9h0m	89	34	result	result	NN
cord-341968-uc8i9h0m	89	35	of	of	IN
cord-341968-uc8i9h0m	89	36	selective	selective	JJ
cord-341968-uc8i9h0m	89	37	evolutionary	evolutionary	JJ
cord-341968-uc8i9h0m	89	38	pressure	pressure	NN
cord-341968-uc8i9h0m	89	39	[	[	-LRB-
cord-341968-uc8i9h0m	89	40	39	39	CD
cord-341968-uc8i9h0m	89	41	]	]	-RRB-
cord-341968-uc8i9h0m	89	42	.	.	.
cord-341968-uc8i9h0m	89	43	 	 	_SP
cord-341968-uc8i9h0m	90	1	Two	two	CD
cord-341968-uc8i9h0m	90	2	proteins	protein	NNS
cord-341968-uc8i9h0m	90	3	predominate	predominate	VBP
cord-341968-uc8i9h0m	90	4	in	in	IN
cord-341968-uc8i9h0m	90	5	the	the	DT
cord-341968-uc8i9h0m	90	6	envelope	envelope	NN
cord-341968-uc8i9h0m	90	7	of	of	IN
cord-341968-uc8i9h0m	90	8	flaviviruses	flavivirus	NNS
cord-341968-uc8i9h0m	90	9	,	,	,
cord-341968-uc8i9h0m	90	10	prM	prm	JJ
cord-341968-uc8i9h0m	90	11	,	,	,
cord-341968-uc8i9h0m	90	12	and	and	CC
cord-341968-uc8i9h0m	90	13	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	90	14	E	e	NN
cord-341968-uc8i9h0m	90	15	[	[	-LRB-
cord-341968-uc8i9h0m	90	16	40	40	CD
cord-341968-uc8i9h0m	90	17	]	]	-RRB-
cord-341968-uc8i9h0m	90	18	.	.	.
cord-341968-uc8i9h0m	91	1	The	the	DT
cord-341968-uc8i9h0m	91	2	association	association	NN
cord-341968-uc8i9h0m	91	3	between	between	IN
cord-341968-uc8i9h0m	91	4	the	the	DT
cord-341968-uc8i9h0m	91	5	two	two	CD
cord-341968-uc8i9h0m	91	6	proteins	protein	NNS
cord-341968-uc8i9h0m	91	7	(	(	-LRB-
cord-341968-uc8i9h0m	91	8	prM	prm	JJ
cord-341968-uc8i9h0m	91	9	-	-	HYPH
cord-341968-uc8i9h0m	91	10	E	e	NN
cord-341968-uc8i9h0m	91	11	)	)	-RRB-
cord-341968-uc8i9h0m	91	12	in	in	IN
cord-341968-uc8i9h0m	91	13	the	the	DT
cord-341968-uc8i9h0m	91	14	immature	immature	JJ
cord-341968-uc8i9h0m	91	15	virus	virus	NN
cord-341968-uc8i9h0m	91	16	changes	change	VBZ
cord-341968-uc8i9h0m	91	17	upon	upon	IN
cord-341968-uc8i9h0m	91	18	cleavage	cleavage	NN
cord-341968-uc8i9h0m	91	19	of	of	IN
cord-341968-uc8i9h0m	91	20	prM	prm	JJ
cord-341968-uc8i9h0m	91	21	by	by	IN
cord-341968-uc8i9h0m	91	22	PCs	pc	NNS
cord-341968-uc8i9h0m	91	23	during	during	IN
cord-341968-uc8i9h0m	91	24	egress	egress	NN
cord-341968-uc8i9h0m	91	25	.	.	.
cord-341968-uc8i9h0m	92	1	The	the	DT
cord-341968-uc8i9h0m	92	2	pr	pr	JJ
cord-341968-uc8i9h0m	92	3	segment	segment	NN
cord-341968-uc8i9h0m	92	4	is	be	VBZ
cord-341968-uc8i9h0m	92	5	removed	remove	VBN
cord-341968-uc8i9h0m	92	6	to	to	TO
cord-341968-uc8i9h0m	92	7	render	render	VB
cord-341968-uc8i9h0m	92	8	the	the	DT
cord-341968-uc8i9h0m	92	9	mature	mature	JJ
cord-341968-uc8i9h0m	92	10	virions	virion	NNS
cord-341968-uc8i9h0m	92	11	(	(	-LRB-
cord-341968-uc8i9h0m	92	12	M	M	NNP
cord-341968-uc8i9h0m	92	13	-	-	HYPH
cord-341968-uc8i9h0m	92	14	E	E	NNP
cord-341968-uc8i9h0m	92	15	)	)	-RRB-
cord-341968-uc8i9h0m	92	16	(	(	-LRB-
cord-341968-uc8i9h0m	92	17	M	M	NNP
cord-341968-uc8i9h0m	92	18	-	-	HYPH
cord-341968-uc8i9h0m	92	19	E	E	NNP
cord-341968-uc8i9h0m	92	20	)	)	-RRB-
cord-341968-uc8i9h0m	92	21	[	[	-LRB-
cord-341968-uc8i9h0m	92	22	41	41	CD
cord-341968-uc8i9h0m	92	23	]	]	-RRB-
cord-341968-uc8i9h0m	92	24	.	.	.
cord-341968-uc8i9h0m	93	1	All	all	DT
cord-341968-uc8i9h0m	93	2	flaviviruses	flavivirus	NNS
cord-341968-uc8i9h0m	93	3	contain	contain	VBP
cord-341968-uc8i9h0m	93	4	a	a	DT
cord-341968-uc8i9h0m	93	5	PC	pc	NN
cord-341968-uc8i9h0m	93	6	cleavage	cleavage	NN
cord-341968-uc8i9h0m	93	7	site	site	NN
cord-341968-uc8i9h0m	93	8	motif	motif	NN
cord-341968-uc8i9h0m	93	9	at	at	IN
cord-341968-uc8i9h0m	93	10	the	the	DT
cord-341968-uc8i9h0m	93	11	pr	pr	NNP
cord-341968-uc8i9h0m	93	12	-	-	HYPH
cord-341968-uc8i9h0m	93	13	M	M	NNP
cord-341968-uc8i9h0m	93	14	junction	junction	NN
cord-341968-uc8i9h0m	93	15	(	(	-LRB-
cord-341968-uc8i9h0m	93	16	Table	Table	NNP
cord-341968-uc8i9h0m	93	17	4	4	CD
cord-341968-uc8i9h0m	93	18	)	)	-RRB-
cord-341968-uc8i9h0m	93	19	.	.	.
cord-341968-uc8i9h0m	94	1	A	a	DT
cord-341968-uc8i9h0m	94	2	peculiar	peculiar	JJ
cord-341968-uc8i9h0m	94	3	case	case	NN
cord-341968-uc8i9h0m	94	4	is	be	VBZ
cord-341968-uc8i9h0m	94	5	the	the	DT
cord-341968-uc8i9h0m	94	6	maturation	maturation	NN
cord-341968-uc8i9h0m	94	7	of	of	IN
cord-341968-uc8i9h0m	94	8	the	the	DT
cord-341968-uc8i9h0m	94	9	Dengue	Dengue	NNP
cord-341968-uc8i9h0m	94	10	virus	virus	NN
cord-341968-uc8i9h0m	94	11	(	(	-LRB-
cord-341968-uc8i9h0m	94	12	DENV	DENV	NNP
cord-341968-uc8i9h0m	94	13	)	)	-RRB-
cord-341968-uc8i9h0m	94	14	.	.	.
cord-341968-uc8i9h0m	95	1	Its	-PRON-	PRP$
cord-341968-uc8i9h0m	95	2	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	95	3	processing	processing	NN
cord-341968-uc8i9h0m	95	4	is	be	VBZ
cord-341968-uc8i9h0m	95	5	known	know	VBN
cord-341968-uc8i9h0m	95	6	to	to	TO
cord-341968-uc8i9h0m	95	7	be	be	VB
cord-341968-uc8i9h0m	95	8	very	very	RB
cord-341968-uc8i9h0m	95	9	inefficient	inefficient	JJ
cord-341968-uc8i9h0m	95	10	,	,	,
cord-341968-uc8i9h0m	95	11	and	and	CC
cord-341968-uc8i9h0m	95	12	virions	virion	NNS
cord-341968-uc8i9h0m	95	13	are	be	VBP
cord-341968-uc8i9h0m	95	14	produced	produce	VBN
cord-341968-uc8i9h0m	95	15	in	in	IN
cord-341968-uc8i9h0m	95	16	the	the	DT
cord-341968-uc8i9h0m	95	17	prM	prm	JJ
cord-341968-uc8i9h0m	95	18	-	-	HYPH
cord-341968-uc8i9h0m	95	19	E	e	NN
cord-341968-uc8i9h0m	95	20	form	form	NN
cord-341968-uc8i9h0m	95	21	in	in	IN
cord-341968-uc8i9h0m	95	22	high	high	JJ
cord-341968-uc8i9h0m	95	23	proportion	proportion	NN
cord-341968-uc8i9h0m	95	24	.	.	.
cord-341968-uc8i9h0m	96	1	It	-PRON-	PRP
cord-341968-uc8i9h0m	96	2	was	be	VBD
cord-341968-uc8i9h0m	96	3	initially	initially	RB
cord-341968-uc8i9h0m	96	4	suspected	suspect	VBN
cord-341968-uc8i9h0m	96	5	that	that	IN
cord-341968-uc8i9h0m	96	6	maturation	maturation	NN
cord-341968-uc8i9h0m	96	7	might	may	MD
cord-341968-uc8i9h0m	96	8	not	not	RB
cord-341968-uc8i9h0m	96	9	be	be	VB
cord-341968-uc8i9h0m	96	10	necessary	necessary	JJ
cord-341968-uc8i9h0m	96	11	for	for	IN
cord-341968-uc8i9h0m	96	12	infectivity	infectivity	NN
cord-341968-uc8i9h0m	96	13	but	but	CC
cord-341968-uc8i9h0m	96	14	later	later	RB
cord-341968-uc8i9h0m	96	15	demonstrated	demonstrate	VBD
cord-341968-uc8i9h0m	96	16	that	that	IN
cord-341968-uc8i9h0m	96	17	it	-PRON-	PRP
cord-341968-uc8i9h0m	96	18	is	be	VBZ
cord-341968-uc8i9h0m	96	19	indeed	indeed	RB
cord-341968-uc8i9h0m	96	20	needed	need	VBN
cord-341968-uc8i9h0m	96	21	[	[	-LRB-
cord-341968-uc8i9h0m	96	22	42	42	CD
cord-341968-uc8i9h0m	96	23	]	]	-RRB-
cord-341968-uc8i9h0m	96	24	.	.	.
cord-341968-uc8i9h0m	97	1	The	the	DT
cord-341968-uc8i9h0m	97	2	inefficient	inefficient	JJ
cord-341968-uc8i9h0m	97	3	maturation	maturation	NN
cord-341968-uc8i9h0m	97	4	of	of	IN
cord-341968-uc8i9h0m	97	5	the	the	DT
cord-341968-uc8i9h0m	97	6	DENV	DENV	NNP
cord-341968-uc8i9h0m	97	7	agrees	agree	VBZ
cord-341968-uc8i9h0m	97	8	with	with	IN
cord-341968-uc8i9h0m	97	9	studies	study	NNS
cord-341968-uc8i9h0m	97	10	that	that	WDT
cord-341968-uc8i9h0m	97	11	show	show	VBP
cord-341968-uc8i9h0m	97	12	that	that	IN
cord-341968-uc8i9h0m	97	13	anti	anti	JJ
cord-341968-uc8i9h0m	97	14	-	-	JJ
cord-341968-uc8i9h0m	97	15	prM	prm	JJ
cord-341968-uc8i9h0m	97	16	antibodies	antibody	NNS
cord-341968-uc8i9h0m	97	17	represent	represent	VBP
cord-341968-uc8i9h0m	97	18	a	a	DT
cord-341968-uc8i9h0m	97	19	significant	significant	JJ
cord-341968-uc8i9h0m	97	20	proportion	proportion	NN
cord-341968-uc8i9h0m	97	21	of	of	IN
cord-341968-uc8i9h0m	97	22	the	the	DT
cord-341968-uc8i9h0m	97	23	immune	immune	JJ
cord-341968-uc8i9h0m	97	24	response	response	NN
cord-341968-uc8i9h0m	97	25	to	to	IN
cord-341968-uc8i9h0m	97	26	DENV	DENV	NNP
cord-341968-uc8i9h0m	97	27	and	and	CC
cord-341968-uc8i9h0m	97	28	that	that	IN
cord-341968-uc8i9h0m	97	29	these	these	DT
cord-341968-uc8i9h0m	97	30	antibodies	antibody	NNS
cord-341968-uc8i9h0m	97	31	are	be	VBP
cord-341968-uc8i9h0m	97	32	responsible	responsible	JJ
cord-341968-uc8i9h0m	97	33	for	for	IN
cord-341968-uc8i9h0m	97	34	the	the	DT
cord-341968-uc8i9h0m	97	35	development	development	NN
cord-341968-uc8i9h0m	97	36	of	of	IN
cord-341968-uc8i9h0m	97	37	antibody	antibody	NN
cord-341968-uc8i9h0m	97	38	-	-	HYPH
cord-341968-uc8i9h0m	97	39	dependent	dependent	JJ
cord-341968-uc8i9h0m	97	40	enhancement	enhancement	NN
cord-341968-uc8i9h0m	97	41	(	(	-LRB-
cord-341968-uc8i9h0m	97	42	ADE	ADE	NNP
cord-341968-uc8i9h0m	97	43	)	)	-RRB-
cord-341968-uc8i9h0m	97	44	of	of	IN
cord-341968-uc8i9h0m	97	45	infection	infection	NN
cord-341968-uc8i9h0m	97	46	in	in	IN
cord-341968-uc8i9h0m	97	47	individuals	individual	NNS
cord-341968-uc8i9h0m	97	48	suffering	suffer	VBG
cord-341968-uc8i9h0m	97	49	from	from	IN
cord-341968-uc8i9h0m	97	50	recurrent	recurrent	JJ
cord-341968-uc8i9h0m	97	51	DENV	DENV	NNP
cord-341968-uc8i9h0m	97	52	infections	infection	NNS
cord-341968-uc8i9h0m	97	53	[	[	-LRB-
cord-341968-uc8i9h0m	97	54	43	43	CD
cord-341968-uc8i9h0m	97	55	]	]	-RRB-
cord-341968-uc8i9h0m	97	56	.	.	.
cord-341968-uc8i9h0m	98	1	These	these	DT
cord-341968-uc8i9h0m	98	2	observations	observation	NNS
cord-341968-uc8i9h0m	98	3	suggest	suggest	VBP
cord-341968-uc8i9h0m	98	4	that	that	IN
cord-341968-uc8i9h0m	98	5	the	the	DT
cord-341968-uc8i9h0m	98	6	DENV	DENV	NNP
cord-341968-uc8i9h0m	98	7	PC	pc	NN
cord-341968-uc8i9h0m	98	8	reactivity	reactivity	NN
cord-341968-uc8i9h0m	98	9	is	be	VBZ
cord-341968-uc8i9h0m	98	10	weaker	weak	JJR
cord-341968-uc8i9h0m	98	11	compared	compare	VBN
cord-341968-uc8i9h0m	98	12	to	to	IN
cord-341968-uc8i9h0m	98	13	that	that	DT
cord-341968-uc8i9h0m	98	14	of	of	IN
cord-341968-uc8i9h0m	98	15	other	other	JJ
cord-341968-uc8i9h0m	98	16	flaviviruses	flavivirus	NNS
cord-341968-uc8i9h0m	98	17	,	,	,
cord-341968-uc8i9h0m	98	18	which	which	WDT
cord-341968-uc8i9h0m	98	19	seem	seem	VBP
cord-341968-uc8i9h0m	98	20	to	to	TO
cord-341968-uc8i9h0m	98	21	mature	mature	VB
cord-341968-uc8i9h0m	98	22	more	more	RBR
cord-341968-uc8i9h0m	98	23	efficiently	efficiently	RB
cord-341968-uc8i9h0m	98	24	.	.	.
cord-341968-uc8i9h0m	99	1	The	the	DT
cord-341968-uc8i9h0m	99	2	PC	pc	NN
cord-341968-uc8i9h0m	99	3	site	site	NN
cord-341968-uc8i9h0m	99	4	sequence	sequence	NN
cord-341968-uc8i9h0m	99	5	alignment	alignment	NN
cord-341968-uc8i9h0m	99	6	presented	present	VBN
cord-341968-uc8i9h0m	99	7	in	in	IN
cord-341968-uc8i9h0m	99	8	Table	Table	NNP
cord-341968-uc8i9h0m	99	9	4	4	CD
cord-341968-uc8i9h0m	99	10	shows	show	VBZ
cord-341968-uc8i9h0m	99	11	that	that	IN
cord-341968-uc8i9h0m	99	12	the	the	DT
cord-341968-uc8i9h0m	99	13	four	four	CD
cord-341968-uc8i9h0m	99	14	DENV	DENV	NNP
cord-341968-uc8i9h0m	99	15	types	type	NNS
cord-341968-uc8i9h0m	99	16	have	have	VBP
cord-341968-uc8i9h0m	99	17	Asp	Asp	NNP
cord-341968-uc8i9h0m	99	18	or	or	CC
cord-341968-uc8i9h0m	99	19	Glu	Glu	NNP
cord-341968-uc8i9h0m	99	20	residues	residue	NNS
cord-341968-uc8i9h0m	99	21	at	at	IN
cord-341968-uc8i9h0m	99	22	the	the	DT
cord-341968-uc8i9h0m	99	23	P3	P3	NNP
cord-341968-uc8i9h0m	99	24	position	position	NN
cord-341968-uc8i9h0m	99	25	of	of	IN
cord-341968-uc8i9h0m	99	26	the	the	DT
cord-341968-uc8i9h0m	99	27	cleavage	cleavage	NN
cord-341968-uc8i9h0m	99	28	site	site	NN
cord-341968-uc8i9h0m	99	29	,	,	,
cord-341968-uc8i9h0m	99	30	compared	compare	VBN
cord-341968-uc8i9h0m	99	31	to	to	IN
cord-341968-uc8i9h0m	99	32	Ser	Ser	NNP
cord-341968-uc8i9h0m	99	33	or	or	CC
cord-341968-uc8i9h0m	99	34	Thr	Thr	NNP
cord-341968-uc8i9h0m	99	35	in	in	IN
cord-341968-uc8i9h0m	99	36	most	most	JJS
cord-341968-uc8i9h0m	99	37	other	other	JJ
cord-341968-uc8i9h0m	99	38	flavivirus	flavivirus	JJ
cord-341968-uc8i9h0m	99	39	sequences	sequence	NNS
cord-341968-uc8i9h0m	99	40	,	,	,
cord-341968-uc8i9h0m	99	41	including	include	VBG
cord-341968-uc8i9h0m	99	42	that	that	DT
cord-341968-uc8i9h0m	99	43	of	of	IN
cord-341968-uc8i9h0m	99	44	the	the	DT
cord-341968-uc8i9h0m	99	45	zika	zika	NNP
cord-341968-uc8i9h0m	99	46	virus	virus	NN
cord-341968-uc8i9h0m	99	47	(	(	-LRB-
cord-341968-uc8i9h0m	99	48	ZIKV	ZIKV	NNP
cord-341968-uc8i9h0m	99	49	)	)	-RRB-
cord-341968-uc8i9h0m	99	50	.	.	.
cord-341968-uc8i9h0m	100	1	Acidic	acidic	JJ
cord-341968-uc8i9h0m	100	2	residues	residue	NNS
cord-341968-uc8i9h0m	100	3	at	at	IN
cord-341968-uc8i9h0m	100	4	this	this	DT
cord-341968-uc8i9h0m	100	5	position	position	NN
cord-341968-uc8i9h0m	100	6	in	in	IN
cord-341968-uc8i9h0m	100	7	the	the	DT
cord-341968-uc8i9h0m	100	8	substrate	substrate	NN
cord-341968-uc8i9h0m	100	9	sequence	sequence	NN
cord-341968-uc8i9h0m	100	10	are	be	VBP
cord-341968-uc8i9h0m	100	11	detrimental	detrimental	JJ
cord-341968-uc8i9h0m	100	12	to	to	IN
cord-341968-uc8i9h0m	100	13	reactivity	reactivity	NN
cord-341968-uc8i9h0m	100	14	with	with	IN
cord-341968-uc8i9h0m	100	15	PCs	pc	NNS
cord-341968-uc8i9h0m	100	16	[	[	-LRB-
cord-341968-uc8i9h0m	100	17	9	9	CD
cord-341968-uc8i9h0m	100	18	]	]	-RRB-
cord-341968-uc8i9h0m	100	19	.	.	.
cord-341968-uc8i9h0m	101	1	Based	base	VBN
cord-341968-uc8i9h0m	101	2	on	on	IN
cord-341968-uc8i9h0m	101	3	these	these	DT
cord-341968-uc8i9h0m	101	4	differences	difference	NNS
cord-341968-uc8i9h0m	101	5	,	,	,
cord-341968-uc8i9h0m	101	6	it	-PRON-	PRP
cord-341968-uc8i9h0m	101	7	is	be	VBZ
cord-341968-uc8i9h0m	101	8	expected	expect	VBN
cord-341968-uc8i9h0m	101	9	that	that	IN
cord-341968-uc8i9h0m	101	10	DENV	DENV	NNP
cord-341968-uc8i9h0m	101	11	reacts	react	VBZ
cord-341968-uc8i9h0m	101	12	with	with	IN
cord-341968-uc8i9h0m	101	13	a	a	DT
cord-341968-uc8i9h0m	101	14	dramatically	dramatically	RB
cord-341968-uc8i9h0m	101	15	lower	low	JJR
cord-341968-uc8i9h0m	101	16	reactivity	reactivity	NN
cord-341968-uc8i9h0m	101	17	toward	toward	IN
cord-341968-uc8i9h0m	101	18	the	the	DT
cord-341968-uc8i9h0m	101	19	PCs	pc	NNS
cord-341968-uc8i9h0m	101	20	compared	compare	VBN
cord-341968-uc8i9h0m	101	21	to	to	IN
cord-341968-uc8i9h0m	101	22	other	other	JJ
cord-341968-uc8i9h0m	101	23	flaviviruses	flavivirus	NNS
cord-341968-uc8i9h0m	101	24	and	and	CC
cord-341968-uc8i9h0m	101	25	that	that	IN
cord-341968-uc8i9h0m	101	26	higher	high	JJR
cord-341968-uc8i9h0m	101	27	rates	rate	NNS
cord-341968-uc8i9h0m	101	28	of	of	IN
cord-341968-uc8i9h0m	101	29	PC	pc	NN
cord-341968-uc8i9h0m	101	30	reactivity	reactivity	NN
cord-341968-uc8i9h0m	101	31	align	align	VBP
cord-341968-uc8i9h0m	101	32	with	with	IN
cord-341968-uc8i9h0m	101	33	the	the	DT
cord-341968-uc8i9h0m	101	34	strong	strong	JJ
cord-341968-uc8i9h0m	101	35	virulence	virulence	NN
cord-341968-uc8i9h0m	101	36	and	and	CC
cord-341968-uc8i9h0m	101	37	broad	broad	JJ
cord-341968-uc8i9h0m	101	38	cell	cell	NN
cord-341968-uc8i9h0m	101	39	tropism	tropism	NN
cord-341968-uc8i9h0m	101	40	observed	observe	VBN
cord-341968-uc8i9h0m	101	41	with	with	IN
cord-341968-uc8i9h0m	101	42	other	other	JJ
cord-341968-uc8i9h0m	101	43	flaviviruses	flavivirus	NNS
cord-341968-uc8i9h0m	101	44	such	such	JJ
cord-341968-uc8i9h0m	101	45	as	as	IN
cord-341968-uc8i9h0m	101	46	[	[	-LRB-
cord-341968-uc8i9h0m	101	47	44	44	CD
cord-341968-uc8i9h0m	101	48	]	]	-RRB-
cord-341968-uc8i9h0m	101	49	.	.	.
cord-341968-uc8i9h0m	102	1	Therefore	therefore	RB
cord-341968-uc8i9h0m	102	2	,	,	,
cord-341968-uc8i9h0m	102	3	it	-PRON-	PRP
cord-341968-uc8i9h0m	102	4	is	be	VBZ
cord-341968-uc8i9h0m	102	5	not	not	RB
cord-341968-uc8i9h0m	102	6	surprising	surprising	JJ
cord-341968-uc8i9h0m	102	7	that	that	IN
cord-341968-uc8i9h0m	102	8	ZIKV	ZIKV	NNP
cord-341968-uc8i9h0m	102	9	can	can	MD
cord-341968-uc8i9h0m	102	10	even	even	RB
cord-341968-uc8i9h0m	102	11	reach	reach	VB
cord-341968-uc8i9h0m	102	12	the	the	DT
cord-341968-uc8i9h0m	102	13	fetus	fetus	NN
cord-341968-uc8i9h0m	102	14	and	and	CC
cord-341968-uc8i9h0m	102	15	remain	remain	VB
cord-341968-uc8i9h0m	102	16	in	in	IN
cord-341968-uc8i9h0m	102	17	bodily	bodily	JJ
cord-341968-uc8i9h0m	102	18	fluids	fluid	NNS
cord-341968-uc8i9h0m	102	19	of	of	IN
cord-341968-uc8i9h0m	102	20	asymptomatic	asymptomatic	JJ
cord-341968-uc8i9h0m	102	21	patients	patient	NNS
cord-341968-uc8i9h0m	102	22	for	for	IN
cord-341968-uc8i9h0m	102	23	more	more	RBR
cord-341968-uc8i9h0m	102	24	extended	extended	JJ
cord-341968-uc8i9h0m	102	25	periods	period	NNS
cord-341968-uc8i9h0m	102	26	when	when	WRB
cord-341968-uc8i9h0m	102	27	compared	compare	VBN
cord-341968-uc8i9h0m	102	28	to	to	IN
cord-341968-uc8i9h0m	102	29	DENV	DENV	NNP
cord-341968-uc8i9h0m	102	30	[	[	-LRB-
cord-341968-uc8i9h0m	102	31	45	45	CD
cord-341968-uc8i9h0m	102	32	]	]	-RRB-
cord-341968-uc8i9h0m	102	33	.	.	.
cord-341968-uc8i9h0m	103	1	Variations	variation	NNS
cord-341968-uc8i9h0m	103	2	of	of	IN
cord-341968-uc8i9h0m	103	3	the	the	DT
cord-341968-uc8i9h0m	103	4	PC	pc	NN
cord-341968-uc8i9h0m	103	5	gene	gene	NN
cord-341968-uc8i9h0m	103	6	expression	expression	NN
cord-341968-uc8i9h0m	103	7	profile	profile	NN
cord-341968-uc8i9h0m	103	8	may	may	MD
cord-341968-uc8i9h0m	103	9	be	be	VB
cord-341968-uc8i9h0m	103	10	a	a	DT
cord-341968-uc8i9h0m	103	11	key	key	JJ
cord-341968-uc8i9h0m	103	12	factor	factor	NN
cord-341968-uc8i9h0m	103	13	determining	determine	VBG
cord-341968-uc8i9h0m	103	14	the	the	DT
cord-341968-uc8i9h0m	103	15	difference	difference	NN
cord-341968-uc8i9h0m	103	16	of	of	IN
cord-341968-uc8i9h0m	103	17	tropism	tropism	NN
cord-341968-uc8i9h0m	103	18	to	to	IN
cord-341968-uc8i9h0m	103	19	testes	testis	NNS
cord-341968-uc8i9h0m	103	20	between	between	IN
cord-341968-uc8i9h0m	103	21	ZIKV	ZIKV	NNP
cord-341968-uc8i9h0m	103	22	and	and	CC
cord-341968-uc8i9h0m	103	23	DENV	DENV	NNP
cord-341968-uc8i9h0m	103	24	.	.	.
cord-341968-uc8i9h0m	104	1	PC4	PC4	NNP
cord-341968-uc8i9h0m	104	2	is	be	VBZ
cord-341968-uc8i9h0m	104	3	the	the	DT
cord-341968-uc8i9h0m	104	4	primary	primary	JJ
cord-341968-uc8i9h0m	104	5	PC	pc	NN
cord-341968-uc8i9h0m	104	6	expressed	express	VBN
cord-341968-uc8i9h0m	104	7	in	in	IN
cord-341968-uc8i9h0m	104	8	testes	testis	NNS
cord-341968-uc8i9h0m	104	9	[	[	-LRB-
cord-341968-uc8i9h0m	104	10	46	46	CD
cord-341968-uc8i9h0m	104	11	]	]	-RRB-
cord-341968-uc8i9h0m	104	12	.	.	.
cord-341968-uc8i9h0m	105	1	A	a	DT
cord-341968-uc8i9h0m	105	2	vigorous	vigorous	JJ
cord-341968-uc8i9h0m	105	3	reactivity	reactivity	NN
cord-341968-uc8i9h0m	105	4	of	of	IN
cord-341968-uc8i9h0m	105	5	ZIKV	ZIKV	NNP
cord-341968-uc8i9h0m	105	6	with	with	IN
cord-341968-uc8i9h0m	105	7	PC4	PC4	NNP
cord-341968-uc8i9h0m	105	8	would	would	MD
cord-341968-uc8i9h0m	105	9	explain	explain	VB
cord-341968-uc8i9h0m	105	10	why	why	WRB
cord-341968-uc8i9h0m	105	11	the	the	DT
cord-341968-uc8i9h0m	105	12	testes	testis	NNS
cord-341968-uc8i9h0m	105	13	suffer	suffer	VBP
cord-341968-uc8i9h0m	105	14	the	the	DT
cord-341968-uc8i9h0m	105	15	highest	high	JJS
cord-341968-uc8i9h0m	105	16	loads	load	NNS
cord-341968-uc8i9h0m	105	17	of	of	IN
cord-341968-uc8i9h0m	105	18	ZIKV	ZIKV	NNP
cord-341968-uc8i9h0m	105	19	compared	compare	VBN
cord-341968-uc8i9h0m	105	20	to	to	IN
cord-341968-uc8i9h0m	105	21	other	other	JJ
cord-341968-uc8i9h0m	105	22	organs	organ	NNS
cord-341968-uc8i9h0m	105	23	and	and	CC
cord-341968-uc8i9h0m	105	24	the	the	DT
cord-341968-uc8i9h0m	105	25	sexual	sexual	JJ
cord-341968-uc8i9h0m	105	26	transmission	transmission	NN
cord-341968-uc8i9h0m	105	27	of	of	IN
cord-341968-uc8i9h0m	105	28	the	the	DT
cord-341968-uc8i9h0m	105	29	virus	virus	NN
cord-341968-uc8i9h0m	105	30	.	.	.
cord-341968-uc8i9h0m	106	1	The	the	DT
cord-341968-uc8i9h0m	106	2	viral	viral	JJ
cord-341968-uc8i9h0m	106	3	PC	pc	NN
cord-341968-uc8i9h0m	106	4	reactivity	reactivity	NN
cord-341968-uc8i9h0m	106	5	and	and	CC
cord-341968-uc8i9h0m	106	6	the	the	DT
cord-341968-uc8i9h0m	106	7	cell	cell	NN
cord-341968-uc8i9h0m	106	8	PC	pc	NN
cord-341968-uc8i9h0m	106	9	gene	gene	NN
cord-341968-uc8i9h0m	106	10	expression	expression	NN
cord-341968-uc8i9h0m	106	11	profile	profile	NN
cord-341968-uc8i9h0m	106	12	both	both	CC
cord-341968-uc8i9h0m	106	13	probably	probably	RB
cord-341968-uc8i9h0m	106	14	play	play	VBP
cord-341968-uc8i9h0m	106	15	a	a	DT
cord-341968-uc8i9h0m	106	16	role	role	NN
cord-341968-uc8i9h0m	106	17	in	in	IN
cord-341968-uc8i9h0m	106	18	determining	determine	VBG
cord-341968-uc8i9h0m	106	19	the	the	DT
cord-341968-uc8i9h0m	106	20	cell	cell	NN
cord-341968-uc8i9h0m	106	21	tropism	tropism	NN
cord-341968-uc8i9h0m	106	22	differences	difference	NNS
cord-341968-uc8i9h0m	106	23	observed	observe	VBN
cord-341968-uc8i9h0m	106	24	with	with	IN
cord-341968-uc8i9h0m	106	25	flaviviruses	flavivirus	NNS
cord-341968-uc8i9h0m	106	26	[	[	-LRB-
cord-341968-uc8i9h0m	106	27	47	47	CD
cord-341968-uc8i9h0m	106	28	]	]	-RRB-
cord-341968-uc8i9h0m	106	29	[	[	-LRB-
cord-341968-uc8i9h0m	106	30	48	48	CD
cord-341968-uc8i9h0m	106	31	]	]	-RRB-
cord-341968-uc8i9h0m	106	32	[	[	-LRB-
cord-341968-uc8i9h0m	106	33	49	49	CD
cord-341968-uc8i9h0m	106	34	]	]	-RRB-
cord-341968-uc8i9h0m	106	35	.	.	.
cord-341968-uc8i9h0m	106	36	 	 	_SP
cord-341968-uc8i9h0m	107	1	Viruses	virus	NNS
cord-341968-uc8i9h0m	107	2	of	of	IN
cord-341968-uc8i9h0m	107	3	the	the	DT
cord-341968-uc8i9h0m	107	4	genus	genus	NN
cord-341968-uc8i9h0m	107	5	Alphavirus	Alphavirus	NNP
cord-341968-uc8i9h0m	107	6	like	like	IN
cord-341968-uc8i9h0m	107	7	Chikungunya	chikungunya	NN
cord-341968-uc8i9h0m	107	8	(	(	-LRB-
cord-341968-uc8i9h0m	107	9	CHIKV	CHIKV	NNP
cord-341968-uc8i9h0m	107	10	)	)	-RRB-
cord-341968-uc8i9h0m	107	11	,	,	,
cord-341968-uc8i9h0m	107	12	Semliki	Semliki	NNP
cord-341968-uc8i9h0m	107	13	forest	forest	NN
cord-341968-uc8i9h0m	107	14	(	(	-LRB-
cord-341968-uc8i9h0m	107	15	SFV	SFV	NNP
cord-341968-uc8i9h0m	107	16	)	)	-RRB-
cord-341968-uc8i9h0m	107	17	,	,	,
cord-341968-uc8i9h0m	107	18	Sindbis	Sindbis	NNP
cord-341968-uc8i9h0m	107	19	,	,	,
cord-341968-uc8i9h0m	107	20	and	and	CC
cord-341968-uc8i9h0m	107	21	Ross	Ross	NNP
cord-341968-uc8i9h0m	107	22	River	River	NNP
cord-341968-uc8i9h0m	107	23	,	,	,
cord-341968-uc8i9h0m	107	24	all	all	DT
cord-341968-uc8i9h0m	107	25	are	be	VBP
cord-341968-uc8i9h0m	107	26	arboviruses	arbovirus	NNS
cord-341968-uc8i9h0m	107	27	structurally	structurally	RB
cord-341968-uc8i9h0m	107	28	related	relate	VBN
cord-341968-uc8i9h0m	107	29	to	to	IN
cord-341968-uc8i9h0m	107	30	flaviviruses	flavivirus	NNS
cord-341968-uc8i9h0m	107	31	[	[	-LRB-
cord-341968-uc8i9h0m	107	32	50	50	CD
cord-341968-uc8i9h0m	107	33	]	]	-RRB-
cord-341968-uc8i9h0m	107	34	.	.	.
cord-341968-uc8i9h0m	108	1	Their	-PRON-	PRP$
cord-341968-uc8i9h0m	108	2	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	108	3	precursor	precursor	NN
cord-341968-uc8i9h0m	108	4	E3E2	E3E2	NNP
cord-341968-uc8i9h0m	108	5	is	be	VBZ
cord-341968-uc8i9h0m	108	6	cleaved	cleave	VBN
cord-341968-uc8i9h0m	108	7	by	by	IN
cord-341968-uc8i9h0m	108	8	PCs	pc	NNS
cord-341968-uc8i9h0m	108	9	in	in	IN
cord-341968-uc8i9h0m	108	10	order	order	NN
cord-341968-uc8i9h0m	108	11	to	to	TO
cord-341968-uc8i9h0m	108	12	regulate	regulate	VB
cord-341968-uc8i9h0m	108	13	its	-PRON-	PRP$
cord-341968-uc8i9h0m	108	14	interaction	interaction	NN
cord-341968-uc8i9h0m	108	15	with	with	IN
cord-341968-uc8i9h0m	108	16	the	the	DT
cord-341968-uc8i9h0m	108	17	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	108	18	E1	e1	NN
cord-341968-uc8i9h0m	108	19	,	,	,
cord-341968-uc8i9h0m	108	20	which	which	WDT
cord-341968-uc8i9h0m	108	21	promotes	promote	VBZ
cord-341968-uc8i9h0m	108	22	virus	virus	NN
cord-341968-uc8i9h0m	108	23	to	to	IN
cord-341968-uc8i9h0m	108	24	cell	cell	NN
cord-341968-uc8i9h0m	108	25	fusion	fusion	NN
cord-341968-uc8i9h0m	108	26	and	and	CC
cord-341968-uc8i9h0m	108	27	infection	infection	NN
cord-341968-uc8i9h0m	108	28	[	[	-LRB-
cord-341968-uc8i9h0m	108	29	51	51	CD
cord-341968-uc8i9h0m	108	30	,	,	,
cord-341968-uc8i9h0m	108	31	52	52	CD
cord-341968-uc8i9h0m	108	32	]	]	-RRB-
cord-341968-uc8i9h0m	108	33	.	.	.
cord-341968-uc8i9h0m	109	1	The	the	DT
cord-341968-uc8i9h0m	109	2	information	information	NN
cord-341968-uc8i9h0m	109	3	available	available	JJ
cord-341968-uc8i9h0m	109	4	about	about	IN
cord-341968-uc8i9h0m	109	5	the	the	DT
cord-341968-uc8i9h0m	109	6	processing	processing	NN
cord-341968-uc8i9h0m	109	7	of	of	IN
cord-341968-uc8i9h0m	109	8	togavirus	togavirus	NNP
cord-341968-uc8i9h0m	109	9	proteins	protein	NNS
cord-341968-uc8i9h0m	109	10	by	by	IN
cord-341968-uc8i9h0m	109	11	PCs	pc	NNS
cord-341968-uc8i9h0m	109	12	is	be	VBZ
cord-341968-uc8i9h0m	109	13	scant	scant	JJ
cord-341968-uc8i9h0m	109	14	,	,	,
cord-341968-uc8i9h0m	109	15	but	but	CC
cord-341968-uc8i9h0m	109	16	it	-PRON-	PRP
cord-341968-uc8i9h0m	109	17	reveals	reveal	VBZ
cord-341968-uc8i9h0m	109	18	the	the	DT
cord-341968-uc8i9h0m	109	19	existence	existence	NN
cord-341968-uc8i9h0m	109	20	of	of	IN
cord-341968-uc8i9h0m	109	21	amino	amino	NN
cord-341968-uc8i9h0m	109	22	acid	acid	NN
cord-341968-uc8i9h0m	109	23	sequence	sequence	NN
cord-341968-uc8i9h0m	109	24	variability	variability	NN
cord-341968-uc8i9h0m	109	25	in	in	IN
cord-341968-uc8i9h0m	109	26	the	the	DT
cord-341968-uc8i9h0m	109	27	PC	pc	NN
cord-341968-uc8i9h0m	109	28	cleavage	cleavage	NN
cord-341968-uc8i9h0m	109	29	sites	site	NNS
cord-341968-uc8i9h0m	109	30	between	between	IN
cord-341968-uc8i9h0m	109	31	the	the	DT
cord-341968-uc8i9h0m	109	32	CHIKV	CHIKV	NNP
cord-341968-uc8i9h0m	109	33	Asian	asian	JJ
cord-341968-uc8i9h0m	109	34	and	and	CC
cord-341968-uc8i9h0m	109	35	African	african	JJ
cord-341968-uc8i9h0m	109	36	strains	strain	NNS
cord-341968-uc8i9h0m	109	37	,	,	,
cord-341968-uc8i9h0m	109	38	and	and	CC
cord-341968-uc8i9h0m	109	39	that	that	IN
cord-341968-uc8i9h0m	109	40	this	this	DT
cord-341968-uc8i9h0m	109	41	variability	variability	NN
cord-341968-uc8i9h0m	109	42	probably	probably	RB
cord-341968-uc8i9h0m	109	43	determines	determine	VBZ
cord-341968-uc8i9h0m	109	44	the	the	DT
cord-341968-uc8i9h0m	109	45	observed	observed	JJ
cord-341968-uc8i9h0m	109	46	differences	difference	NNS
cord-341968-uc8i9h0m	109	47	of	of	IN
cord-341968-uc8i9h0m	109	48	PC	pc	NN
cord-341968-uc8i9h0m	109	49	selectivity	selectivity	NN
cord-341968-uc8i9h0m	109	50	[	[	-LRB-
cord-341968-uc8i9h0m	109	51	52	52	CD
cord-341968-uc8i9h0m	109	52	]	]	-RRB-
cord-341968-uc8i9h0m	109	53	.	.	.
cord-341968-uc8i9h0m	110	1	The	the	DT
cord-341968-uc8i9h0m	110	2	family	family	NN
cord-341968-uc8i9h0m	110	3	of	of	IN
cord-341968-uc8i9h0m	110	4	coronaviruses	coronaviruse	NNS
cord-341968-uc8i9h0m	110	5	includes	include	VBZ
cord-341968-uc8i9h0m	110	6	viruses	virus	NNS
cord-341968-uc8i9h0m	110	7	of	of	IN
cord-341968-uc8i9h0m	110	8	relevance	relevance	NN
cord-341968-uc8i9h0m	110	9	to	to	IN
cord-341968-uc8i9h0m	110	10	human	human	JJ
cord-341968-uc8i9h0m	110	11	and	and	CC
cord-341968-uc8i9h0m	110	12	veterinary	veterinary	JJ
cord-341968-uc8i9h0m	110	13	health	health	NN
cord-341968-uc8i9h0m	110	14	.	.	.
cord-341968-uc8i9h0m	111	1	Like	like	IN
cord-341968-uc8i9h0m	111	2	other	other	JJ
cord-341968-uc8i9h0m	111	3	enveloped	envelop	VBN
cord-341968-uc8i9h0m	111	4	viruses	virus	NNS
cord-341968-uc8i9h0m	111	5	that	that	WDT
cord-341968-uc8i9h0m	111	6	rely	rely	VBP
cord-341968-uc8i9h0m	111	7	on	on	IN
cord-341968-uc8i9h0m	111	8	surface	surface	NN
cord-341968-uc8i9h0m	111	9	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	111	10	for	for	IN
cord-341968-uc8i9h0m	111	11	binding	binding	NN
cord-341968-uc8i9h0m	111	12	and	and	CC
cord-341968-uc8i9h0m	111	13	fusion	fusion	NN
cord-341968-uc8i9h0m	111	14	,	,	,
cord-341968-uc8i9h0m	111	15	coronaviruses	coronaviruse	NNS
cord-341968-uc8i9h0m	111	16	have	have	VBP
cord-341968-uc8i9h0m	111	17	the	the	DT
cord-341968-uc8i9h0m	111	18	Spike	spike	NN
cord-341968-uc8i9h0m	111	19	(	(	-LRB-
cord-341968-uc8i9h0m	111	20	S	s	NN
cord-341968-uc8i9h0m	111	21	)	)	-RRB-
cord-341968-uc8i9h0m	111	22	protein	protein	NN
cord-341968-uc8i9h0m	111	23	,	,	,
cord-341968-uc8i9h0m	111	24	which	which	WDT
cord-341968-uc8i9h0m	111	25	is	be	VBZ
cord-341968-uc8i9h0m	111	26	cleaved	cleave	VBN
cord-341968-uc8i9h0m	111	27	by	by	IN
cord-341968-uc8i9h0m	111	28	proteases	protease	NNS
cord-341968-uc8i9h0m	111	29	during	during	IN
cord-341968-uc8i9h0m	111	30	virion	virion	NN
cord-341968-uc8i9h0m	111	31	biosynthesis	biosynthesis	NN
cord-341968-uc8i9h0m	111	32	,	,	,
cord-341968-uc8i9h0m	111	33	as	as	RB
cord-341968-uc8i9h0m	111	34	well	well	RB
cord-341968-uc8i9h0m	111	35	as	as	IN
cord-341968-uc8i9h0m	111	36	during	during	IN
cord-341968-uc8i9h0m	111	37	entry	entry	NN
cord-341968-uc8i9h0m	111	38	into	into	IN
cord-341968-uc8i9h0m	111	39	target	target	NN
cord-341968-uc8i9h0m	111	40	cells	cell	NNS
cord-341968-uc8i9h0m	111	41	[	[	-LRB-
cord-341968-uc8i9h0m	111	42	53	53	CD
cord-341968-uc8i9h0m	111	43	]	]	-RRB-
cord-341968-uc8i9h0m	111	44	.	.	.
cord-341968-uc8i9h0m	112	1	The	the	DT
cord-341968-uc8i9h0m	112	2	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	112	3	regulation	regulation	NN
cord-341968-uc8i9h0m	112	4	of	of	IN
cord-341968-uc8i9h0m	112	5	coronaviruses	coronaviruse	NNS
cord-341968-uc8i9h0m	112	6	is	be	VBZ
cord-341968-uc8i9h0m	112	7	probably	probably	RB
cord-341968-uc8i9h0m	112	8	one	one	CD
cord-341968-uc8i9h0m	112	9	of	of	IN
cord-341968-uc8i9h0m	112	10	the	the	DT
cord-341968-uc8i9h0m	112	11	best	well	RBS
cord-341968-uc8i9h0m	112	12	-	-	HYPH
cord-341968-uc8i9h0m	112	13	studied	study	VBN
cord-341968-uc8i9h0m	112	14	systems	system	NNS
cord-341968-uc8i9h0m	112	15	,	,	,
cord-341968-uc8i9h0m	112	16	and	and	CC
cord-341968-uc8i9h0m	112	17	a	a	DT
cord-341968-uc8i9h0m	112	18	complete	complete	JJ
cord-341968-uc8i9h0m	112	19	picture	picture	NN
cord-341968-uc8i9h0m	112	20	of	of	IN
cord-341968-uc8i9h0m	112	21	the	the	DT
cord-341968-uc8i9h0m	112	22	regulatory	regulatory	JJ
cord-341968-uc8i9h0m	112	23	system	system	NN
cord-341968-uc8i9h0m	112	24	mechanism	mechanism	NN
cord-341968-uc8i9h0m	112	25	has	have	VBZ
cord-341968-uc8i9h0m	112	26	been	be	VBN
cord-341968-uc8i9h0m	112	27	developed	develop	VBN
cord-341968-uc8i9h0m	112	28	compared	compare	VBN
cord-341968-uc8i9h0m	112	29	to	to	IN
cord-341968-uc8i9h0m	112	30	other	other	JJ
cord-341968-uc8i9h0m	112	31	families	family	NNS
cord-341968-uc8i9h0m	112	32	of	of	IN
cord-341968-uc8i9h0m	112	33	viruses	virus	NNS
cord-341968-uc8i9h0m	112	34	that	that	WDT
cord-341968-uc8i9h0m	112	35	are	be	VBP
cord-341968-uc8i9h0m	112	36	less	less	RBR
cord-341968-uc8i9h0m	112	37	well	well	RB
cord-341968-uc8i9h0m	112	38	-	-	HYPH
cord-341968-uc8i9h0m	112	39	studied	study	VBN
cord-341968-uc8i9h0m	112	40	.	.	.
cord-341968-uc8i9h0m	113	1	The	the	DT
cord-341968-uc8i9h0m	113	2	general	general	JJ
cord-341968-uc8i9h0m	113	3	principles	principle	NNS
cord-341968-uc8i9h0m	113	4	of	of	IN
cord-341968-uc8i9h0m	113	5	the	the	DT
cord-341968-uc8i9h0m	113	6	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	113	7	regulatory	regulatory	JJ
cord-341968-uc8i9h0m	113	8	mechanism	mechanism	NN
cord-341968-uc8i9h0m	113	9	of	of	IN
cord-341968-uc8i9h0m	113	10	coronaviruses	coronaviruse	NNS
cord-341968-uc8i9h0m	113	11	based	base	VBN
cord-341968-uc8i9h0m	113	12	on	on	IN
cord-341968-uc8i9h0m	113	13	the	the	DT
cord-341968-uc8i9h0m	113	14	accumulated	accumulate	VBN
cord-341968-uc8i9h0m	113	15	evidence	evidence	NN
cord-341968-uc8i9h0m	113	16	include	include	VBP
cord-341968-uc8i9h0m	113	17	:	:	:
cord-341968-uc8i9h0m	113	18	(	(	-LRB-
cord-341968-uc8i9h0m	113	19	1	1	LS
cord-341968-uc8i9h0m	113	20	)	)	-RRB-
cord-341968-uc8i9h0m	113	21	these	these	DT
cord-341968-uc8i9h0m	113	22	viruses	virus	NNS
cord-341968-uc8i9h0m	113	23	are	be	VBP
cord-341968-uc8i9h0m	113	24	regulated	regulate	VBN
cord-341968-uc8i9h0m	113	25	by	by	IN
cord-341968-uc8i9h0m	113	26	a	a	DT
cord-341968-uc8i9h0m	113	27	variety	variety	NN
cord-341968-uc8i9h0m	113	28	of	of	IN
cord-341968-uc8i9h0m	113	29	proteases	protease	NNS
cord-341968-uc8i9h0m	113	30	,	,	,
cord-341968-uc8i9h0m	113	31	(	(	-LRB-
cord-341968-uc8i9h0m	113	32	2	2	LS
cord-341968-uc8i9h0m	113	33	)	)	-RRB-
cord-341968-uc8i9h0m	113	34	the	the	DT
cord-341968-uc8i9h0m	113	35	protein	protein	NN
cord-341968-uc8i9h0m	113	36	S	S	NNP
cord-341968-uc8i9h0m	113	37	is	be	VBZ
cord-341968-uc8i9h0m	113	38	cleaved	cleave	VBN
cord-341968-uc8i9h0m	113	39	sequentially	sequentially	RB
cord-341968-uc8i9h0m	113	40	at	at	IN
cord-341968-uc8i9h0m	113	41	two	two	CD
cord-341968-uc8i9h0m	113	42	cleavage	cleavage	NN
cord-341968-uc8i9h0m	113	43	sites	site	NNS
cord-341968-uc8i9h0m	113	44	,	,	,
cord-341968-uc8i9h0m	113	45	(	(	-LRB-
cord-341968-uc8i9h0m	113	46	3	3	LS
cord-341968-uc8i9h0m	113	47	)	)	-RRB-
cord-341968-uc8i9h0m	113	48	viruses	virus	NNS
cord-341968-uc8i9h0m	113	49	can	can	MD
cord-341968-uc8i9h0m	113	50	quickly	quickly	RB
cord-341968-uc8i9h0m	113	51	adapt	adapt	VB
cord-341968-uc8i9h0m	113	52	to	to	IN
cord-341968-uc8i9h0m	113	53	the	the	DT
cord-341968-uc8i9h0m	113	54	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	113	55	environment	environment	NN
cord-341968-uc8i9h0m	113	56	of	of	IN
cord-341968-uc8i9h0m	113	57	the	the	DT
cord-341968-uc8i9h0m	113	58	infected	infected	JJ
cord-341968-uc8i9h0m	113	59	cells	cell	NNS
cord-341968-uc8i9h0m	113	60	,	,	,
cord-341968-uc8i9h0m	113	61	and	and	CC
cord-341968-uc8i9h0m	113	62	(	(	-LRB-
cord-341968-uc8i9h0m	113	63	4	4	LS
cord-341968-uc8i9h0m	113	64	)	)	-RRB-
cord-341968-uc8i9h0m	113	65	the	the	DT
cord-341968-uc8i9h0m	113	66	compatibility	compatibility	NN
cord-341968-uc8i9h0m	113	67	between	between	IN
cord-341968-uc8i9h0m	113	68	the	the	DT
cord-341968-uc8i9h0m	113	69	cleavage	cleavage	NN
cord-341968-uc8i9h0m	113	70	site	site	NN
cord-341968-uc8i9h0m	113	71	-	-	HYPH
cord-341968-uc8i9h0m	113	72	specificity	specificity	NN
cord-341968-uc8i9h0m	113	73	and	and	CC
cord-341968-uc8i9h0m	113	74	cell	cell	NN
cord-341968-uc8i9h0m	113	75	protease	protease	NN
cord-341968-uc8i9h0m	113	76	expression	expression	NN
cord-341968-uc8i9h0m	113	77	profile	profile	NN
cord-341968-uc8i9h0m	113	78	determines	determine	VBZ
cord-341968-uc8i9h0m	113	79	the	the	DT
cord-341968-uc8i9h0m	113	80	cell	cell	NN
cord-341968-uc8i9h0m	113	81	and	and	CC
cord-341968-uc8i9h0m	113	82	tissue	tissue	NN
cord-341968-uc8i9h0m	113	83	tropism	tropism	NN
cord-341968-uc8i9h0m	113	84	and	and	CC
cord-341968-uc8i9h0m	113	85	pathogenicity	pathogenicity	NN
cord-341968-uc8i9h0m	113	86	of	of	IN
cord-341968-uc8i9h0m	113	87	the	the	DT
cord-341968-uc8i9h0m	113	88	virus	virus	NN
cord-341968-uc8i9h0m	113	89	.	.	.
cord-341968-uc8i9h0m	114	1	Furin	furin	NN
cord-341968-uc8i9h0m	114	2	is	be	VBZ
cord-341968-uc8i9h0m	114	3	not	not	RB
cord-341968-uc8i9h0m	114	4	the	the	DT
cord-341968-uc8i9h0m	114	5	only	only	JJ
cord-341968-uc8i9h0m	114	6	protease	protease	NN
cord-341968-uc8i9h0m	114	7	that	that	WDT
cord-341968-uc8i9h0m	114	8	regulates	regulate	VBZ
cord-341968-uc8i9h0m	114	9	the	the	DT
cord-341968-uc8i9h0m	114	10	function	function	NN
cord-341968-uc8i9h0m	114	11	of	of	IN
cord-341968-uc8i9h0m	114	12	the	the	DT
cord-341968-uc8i9h0m	114	13	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	114	14	fusion	fusion	NN
cord-341968-uc8i9h0m	114	15	protein	protein	NN
cord-341968-uc8i9h0m	114	16	.	.	.
cord-341968-uc8i9h0m	115	1	Other	other	JJ
cord-341968-uc8i9h0m	115	2	proteases	protease	NNS
cord-341968-uc8i9h0m	115	3	,	,	,
cord-341968-uc8i9h0m	115	4	such	such	JJ
cord-341968-uc8i9h0m	115	5	as	as	IN
cord-341968-uc8i9h0m	115	6	the	the	DT
cord-341968-uc8i9h0m	115	7	membrane	membrane	NN
cord-341968-uc8i9h0m	115	8	-	-	HYPH
cord-341968-uc8i9h0m	115	9	bound	bind	VBN
cord-341968-uc8i9h0m	115	10	TMPRSS	TMPRSS	NNP
cord-341968-uc8i9h0m	115	11	,	,	,
cord-341968-uc8i9h0m	115	12	the	the	DT
cord-341968-uc8i9h0m	115	13	lysosomal	lysosomal	JJ
cord-341968-uc8i9h0m	115	14	cathepsins	cathepsin	NNS
cord-341968-uc8i9h0m	115	15	,	,	,
cord-341968-uc8i9h0m	115	16	elastase	elastase	NN
cord-341968-uc8i9h0m	115	17	,	,	,
cord-341968-uc8i9h0m	115	18	and	and	CC
cord-341968-uc8i9h0m	115	19	coagulation	coagulation	NN
cord-341968-uc8i9h0m	115	20	factor	factor	NN
cord-341968-uc8i9h0m	116	1	Xa	Xa	NNP
cord-341968-uc8i9h0m	116	2	have	have	VBP
cord-341968-uc8i9h0m	116	3	also	also	RB
cord-341968-uc8i9h0m	116	4	been	be	VBN
cord-341968-uc8i9h0m	116	5	implicated	implicate	VBN
cord-341968-uc8i9h0m	116	6	[	[	-LRB-
cord-341968-uc8i9h0m	116	7	54	54	CD
cord-341968-uc8i9h0m	116	8	,	,	,
cord-341968-uc8i9h0m	116	9	55	55	CD
cord-341968-uc8i9h0m	116	10	]	]	-RRB-
cord-341968-uc8i9h0m	116	11	.	.	.
cord-341968-uc8i9h0m	117	1	Protein	Protein	NNP
cord-341968-uc8i9h0m	117	2	S	S	NNP
cord-341968-uc8i9h0m	117	3	is	be	VBZ
cord-341968-uc8i9h0m	117	4	cleaved	cleave	VBN
cord-341968-uc8i9h0m	117	5	at	at	IN
cord-341968-uc8i9h0m	117	6	the	the	DT
cord-341968-uc8i9h0m	117	7	S1-S2	S1-S2	NNP
cord-341968-uc8i9h0m	117	8	junction	junction	NN
cord-341968-uc8i9h0m	117	9	during	during	IN
cord-341968-uc8i9h0m	117	10	biosynthesis	biosynthesis	NN
cord-341968-uc8i9h0m	117	11	to	to	TO
cord-341968-uc8i9h0m	117	12	separate	separate	VB
cord-341968-uc8i9h0m	117	13	the	the	DT
cord-341968-uc8i9h0m	117	14	two	two	CD
cord-341968-uc8i9h0m	117	15	major	major	JJ
cord-341968-uc8i9h0m	117	16	domains	domain	NNS
cord-341968-uc8i9h0m	117	17	of	of	IN
cord-341968-uc8i9h0m	117	18	the	the	DT
cord-341968-uc8i9h0m	117	19	protein	protein	NN
cord-341968-uc8i9h0m	117	20	.	.	.
cord-341968-uc8i9h0m	118	1	The	the	DT
cord-341968-uc8i9h0m	118	2	S1	s1	NN
cord-341968-uc8i9h0m	118	3	domain	domain	NN
cord-341968-uc8i9h0m	118	4	is	be	VBZ
cord-341968-uc8i9h0m	118	5	involved	involve	VBN
cord-341968-uc8i9h0m	118	6	in	in	IN
cord-341968-uc8i9h0m	118	7	receptor	receptor	NN
cord-341968-uc8i9h0m	118	8	binding	binding	NN
cord-341968-uc8i9h0m	118	9	,	,	,
cord-341968-uc8i9h0m	118	10	and	and	CC
cord-341968-uc8i9h0m	118	11	the	the	DT
cord-341968-uc8i9h0m	118	12	S2	S2	NNP
cord-341968-uc8i9h0m	118	13	domain	domain	NN
cord-341968-uc8i9h0m	118	14	mediates	mediate	VBZ
cord-341968-uc8i9h0m	118	15	the	the	DT
cord-341968-uc8i9h0m	118	16	fusion	fusion	NN
cord-341968-uc8i9h0m	118	17	step	step	NN
cord-341968-uc8i9h0m	118	18	of	of	IN
cord-341968-uc8i9h0m	118	19	the	the	DT
cord-341968-uc8i9h0m	118	20	cell	cell	NN
cord-341968-uc8i9h0m	118	21	entry	entry	NN
cord-341968-uc8i9h0m	118	22	mechanism	mechanism	NN
cord-341968-uc8i9h0m	118	23	.	.	.
cord-341968-uc8i9h0m	119	1	During	during	IN
cord-341968-uc8i9h0m	119	2	cell	cell	NN
cord-341968-uc8i9h0m	119	3	entry	entry	NN
cord-341968-uc8i9h0m	119	4	,	,	,
cord-341968-uc8i9h0m	119	5	the	the	DT
cord-341968-uc8i9h0m	119	6	cleavage	cleavage	NN
cord-341968-uc8i9h0m	119	7	at	at	IN
cord-341968-uc8i9h0m	119	8	S1-S2	S1-S2	NNP
cord-341968-uc8i9h0m	119	9	primes	prime	NNS
cord-341968-uc8i9h0m	119	10	S	S	NNP
cord-341968-uc8i9h0m	119	11	for	for	IN
cord-341968-uc8i9h0m	119	12	the	the	DT
cord-341968-uc8i9h0m	119	13	second	second	JJ
cord-341968-uc8i9h0m	119	14	cleavage	cleavage	NN
cord-341968-uc8i9h0m	119	15	at	at	IN
cord-341968-uc8i9h0m	119	16	the	the	DT
cord-341968-uc8i9h0m	119	17	S2	S2	NNP
cord-341968-uc8i9h0m	119	18	site	site	NN
cord-341968-uc8i9h0m	119	19	[	[	-LRB-
cord-341968-uc8i9h0m	119	20	56	56	CD
cord-341968-uc8i9h0m	119	21	]	]	-RRB-
cord-341968-uc8i9h0m	119	22	[	[	-LRB-
cord-341968-uc8i9h0m	119	23	57	57	CD
cord-341968-uc8i9h0m	119	24	]	]	-RRB-
cord-341968-uc8i9h0m	119	25	[	[	-LRB-
cord-341968-uc8i9h0m	119	26	58	58	CD
cord-341968-uc8i9h0m	119	27	]	]	-RRB-
cord-341968-uc8i9h0m	119	28	[	[	-LRB-
cord-341968-uc8i9h0m	119	29	59	59	CD
cord-341968-uc8i9h0m	119	30	]	]	-RRB-
cord-341968-uc8i9h0m	119	31	.	.	.
cord-341968-uc8i9h0m	120	1	In	in	IN
cord-341968-uc8i9h0m	120	2	many	many	JJ
cord-341968-uc8i9h0m	120	3	coronaviruses	coronaviruse	NNS
cord-341968-uc8i9h0m	120	4	,	,	,
cord-341968-uc8i9h0m	120	5	the	the	DT
cord-341968-uc8i9h0m	120	6	S1-S2	S1-S2	NNP
cord-341968-uc8i9h0m	120	7	cleavage	cleavage	NN
cord-341968-uc8i9h0m	120	8	seems	seem	VBZ
cord-341968-uc8i9h0m	120	9	to	to	TO
cord-341968-uc8i9h0m	120	10	be	be	VB
cord-341968-uc8i9h0m	120	11	dispensable	dispensable	JJ
cord-341968-uc8i9h0m	120	12	;	;	:
cord-341968-uc8i9h0m	120	13	however	however	RB
cord-341968-uc8i9h0m	120	14	,	,	,
cord-341968-uc8i9h0m	120	15	the	the	DT
cord-341968-uc8i9h0m	120	16	cleavage	cleavage	NN
cord-341968-uc8i9h0m	120	17	at	at	IN
cord-341968-uc8i9h0m	120	18	S2	S2	NNP
cord-341968-uc8i9h0m	120	19	is	be	VBZ
cord-341968-uc8i9h0m	120	20	not	not	RB
cord-341968-uc8i9h0m	120	21	.	.	.
cord-341968-uc8i9h0m	121	1	The	the	DT
cord-341968-uc8i9h0m	121	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	121	3	at	at	IN
cord-341968-uc8i9h0m	121	4	S2	S2	NNP
cord-341968-uc8i9h0m	121	5	has	have	VBZ
cord-341968-uc8i9h0m	121	6	been	be	VBN
cord-341968-uc8i9h0m	121	7	suggested	suggest	VBN
cord-341968-uc8i9h0m	121	8	to	to	TO
cord-341968-uc8i9h0m	121	9	serve	serve	VB
cord-341968-uc8i9h0m	121	10	as	as	IN
cord-341968-uc8i9h0m	121	11	a	a	DT
cord-341968-uc8i9h0m	121	12	virulence	virulence	NN
cord-341968-uc8i9h0m	121	13	marker	marker	NN
cord-341968-uc8i9h0m	121	14	[	[	-LRB-
cord-341968-uc8i9h0m	121	15	53	53	CD
cord-341968-uc8i9h0m	121	16	]	]	-RRB-
cord-341968-uc8i9h0m	121	17	.	.	.
cord-341968-uc8i9h0m	122	1	Predictions	prediction	NNS
cord-341968-uc8i9h0m	122	2	of	of	IN
cord-341968-uc8i9h0m	122	3	the	the	DT
cord-341968-uc8i9h0m	122	4	furin	furin	NN
cord-341968-uc8i9h0m	122	5	/	/	SYM
cord-341968-uc8i9h0m	122	6	PC	pc	NN
cord-341968-uc8i9h0m	122	7	reactivity	reactivity	NN
cord-341968-uc8i9h0m	122	8	,	,	,
cord-341968-uc8i9h0m	122	9	based	base	VBN
cord-341968-uc8i9h0m	122	10	on	on	IN
cord-341968-uc8i9h0m	122	11	the	the	DT
cord-341968-uc8i9h0m	122	12	amino	amino	NN
cord-341968-uc8i9h0m	122	13	acid	acid	NN
cord-341968-uc8i9h0m	122	14	sequence	sequence	NN
cord-341968-uc8i9h0m	122	15	surrounding	surround	VBG
cord-341968-uc8i9h0m	122	16	the	the	DT
cord-341968-uc8i9h0m	122	17	cleavage	cleavage	NN
cord-341968-uc8i9h0m	122	18	site	site	NN
cord-341968-uc8i9h0m	122	19	,	,	,
cord-341968-uc8i9h0m	122	20	have	have	VBP
cord-341968-uc8i9h0m	122	21	been	be	VBN
cord-341968-uc8i9h0m	122	22	made	make	VBN
cord-341968-uc8i9h0m	122	23	based	base	VBN
cord-341968-uc8i9h0m	122	24	on	on	IN
cord-341968-uc8i9h0m	122	25	computer	computer	NN
cord-341968-uc8i9h0m	122	26	algorithms	algorithm	NNS
cord-341968-uc8i9h0m	122	27	[	[	-LRB-
cord-341968-uc8i9h0m	122	28	13	13	CD
cord-341968-uc8i9h0m	122	29	]	]	-RRB-
cord-341968-uc8i9h0m	122	30	;	;	:
cord-341968-uc8i9h0m	122	31	however	however	RB
cord-341968-uc8i9h0m	122	32	,	,	,
cord-341968-uc8i9h0m	122	33	the	the	DT
cord-341968-uc8i9h0m	122	34	dependency	dependency	NN
cord-341968-uc8i9h0m	122	35	of	of	IN
cord-341968-uc8i9h0m	122	36	furin	furin	NN
cord-341968-uc8i9h0m	122	37	/	/	SYM
cord-341968-uc8i9h0m	122	38	PC	pc	NN
cord-341968-uc8i9h0m	122	39	reactivity	reactivity	NN
cord-341968-uc8i9h0m	122	40	on	on	IN
cord-341968-uc8i9h0m	122	41	the	the	DT
cord-341968-uc8i9h0m	122	42	conformation	conformation	NN
cord-341968-uc8i9h0m	122	43	of	of	IN
cord-341968-uc8i9h0m	122	44	the	the	DT
cord-341968-uc8i9h0m	122	45	substrate	substrate	NN
cord-341968-uc8i9h0m	122	46	and	and	CC
cord-341968-uc8i9h0m	122	47	exosites	exosite	NNS
cord-341968-uc8i9h0m	122	48	lends	lend	VBZ
cord-341968-uc8i9h0m	122	49	uncertainty	uncertainty	NN
cord-341968-uc8i9h0m	122	50	to	to	IN
cord-341968-uc8i9h0m	122	51	those	those	DT
cord-341968-uc8i9h0m	122	52	predictions	prediction	NNS
cord-341968-uc8i9h0m	122	53	.	.	.
cord-341968-uc8i9h0m	123	1	The	the	DT
cord-341968-uc8i9h0m	123	2	highly	highly	RB
cord-341968-uc8i9h0m	123	3	virulent	virulent	JJ
cord-341968-uc8i9h0m	123	4	MERS	MERS	NNP
cord-341968-uc8i9h0m	123	5	-	-	HYPH
cord-341968-uc8i9h0m	123	6	CoV	CoV	NNP
cord-341968-uc8i9h0m	123	7	(	(	-LRB-
cord-341968-uc8i9h0m	123	8	Middle	Middle	NNP
cord-341968-uc8i9h0m	123	9	East	East	NNP
cord-341968-uc8i9h0m	123	10	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	123	11	syndrome	syndrome	NN
cord-341968-uc8i9h0m	123	12	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	123	13	)	)	-RRB-
cord-341968-uc8i9h0m	123	14	is	be	VBZ
cord-341968-uc8i9h0m	123	15	the	the	DT
cord-341968-uc8i9h0m	123	16	only	only	JJ
cord-341968-uc8i9h0m	123	17	natural	natural	JJ
cord-341968-uc8i9h0m	123	18	virus	virus	NN
cord-341968-uc8i9h0m	123	19	known	know	VBN
cord-341968-uc8i9h0m	123	20	to	to	TO
cord-341968-uc8i9h0m	123	21	have	have	VB
cord-341968-uc8i9h0m	123	22	PC	pc	NN
cord-341968-uc8i9h0m	123	23	cleavage	cleavage	NN
cord-341968-uc8i9h0m	123	24	site	site	NN
cord-341968-uc8i9h0m	123	25	motifs	motif	NNS
cord-341968-uc8i9h0m	123	26	at	at	IN
cord-341968-uc8i9h0m	123	27	both	both	CC
cord-341968-uc8i9h0m	123	28	the	the	DT
cord-341968-uc8i9h0m	123	29	S1-S2	S1-S2	NNP
cord-341968-uc8i9h0m	123	30	and	and	CC
cord-341968-uc8i9h0m	123	31	S2	s2	NN
cord-341968-uc8i9h0m	123	32	sites	site	NNS
cord-341968-uc8i9h0m	123	33	.	.	.
cord-341968-uc8i9h0m	124	1	Other	other	JJ
cord-341968-uc8i9h0m	124	2	viruses	virus	NNS
cord-341968-uc8i9h0m	124	3	with	with	IN
cord-341968-uc8i9h0m	124	4	two	two	CD
cord-341968-uc8i9h0m	124	5	PC	pc	NN
cord-341968-uc8i9h0m	124	6	sites	site	NNS
cord-341968-uc8i9h0m	124	7	are	be	VBP
cord-341968-uc8i9h0m	124	8	the	the	DT
cord-341968-uc8i9h0m	124	9	result	result	NN
cord-341968-uc8i9h0m	124	10	of	of	IN
cord-341968-uc8i9h0m	124	11	laboratory	laboratory	NN
cord-341968-uc8i9h0m	124	12	selection	selection	NN
cord-341968-uc8i9h0m	124	13	by	by	IN
cord-341968-uc8i9h0m	124	14	their	-PRON-	PRP$
cord-341968-uc8i9h0m	124	15	serial	serial	JJ
cord-341968-uc8i9h0m	124	16	passage	passage	NN
cord-341968-uc8i9h0m	124	17	in	in	IN
cord-341968-uc8i9h0m	124	18	cell	cell	NN
cord-341968-uc8i9h0m	124	19	lines	line	NNS
cord-341968-uc8i9h0m	124	20	in	in	IN
cord-341968-uc8i9h0m	124	21	vitro	vitro	FW
cord-341968-uc8i9h0m	124	22	,	,	,
cord-341968-uc8i9h0m	124	23	one	one	CD
cord-341968-uc8i9h0m	124	24	such	such	JJ
cord-341968-uc8i9h0m	124	25	virus	virus	NN
cord-341968-uc8i9h0m	124	26	being	be	VBG
cord-341968-uc8i9h0m	124	27	the	the	DT
cord-341968-uc8i9h0m	124	28	infectious	infectious	JJ
cord-341968-uc8i9h0m	124	29	bronchitis	bronchitis	NN
cord-341968-uc8i9h0m	124	30	virus	virus	NN
cord-341968-uc8i9h0m	124	31	IBV	IBV	NNP
cord-341968-uc8i9h0m	124	32	-	-	HYPH
cord-341968-uc8i9h0m	124	33	Beaudette	Beaudette	NNP
cord-341968-uc8i9h0m	124	34	strain	strain	NN
cord-341968-uc8i9h0m	124	35	[	[	-LRB-
cord-341968-uc8i9h0m	124	36	60	60	CD
cord-341968-uc8i9h0m	124	37	]	]	-RRB-
cord-341968-uc8i9h0m	124	38	.	.	.
cord-341968-uc8i9h0m	125	1	MERS	MERS	NNP
cord-341968-uc8i9h0m	125	2	-	-	HYPH
cord-341968-uc8i9h0m	125	3	CoV	CoV	NNP
cord-341968-uc8i9h0m	125	4	has	have	VBZ
cord-341968-uc8i9h0m	125	5	an	an	DT
cord-341968-uc8i9h0m	125	6	expanded	expand	VBN
cord-341968-uc8i9h0m	125	7	tropism	tropism	NN
cord-341968-uc8i9h0m	125	8	compared	compare	VBN
cord-341968-uc8i9h0m	125	9	to	to	IN
cord-341968-uc8i9h0m	125	10	other	other	JJ
cord-341968-uc8i9h0m	125	11	coronaviruses	coronaviruse	NNS
cord-341968-uc8i9h0m	125	12	,	,	,
cord-341968-uc8i9h0m	125	13	so	so	CC
cord-341968-uc8i9h0m	125	14	it	-PRON-	PRP
cord-341968-uc8i9h0m	125	15	is	be	VBZ
cord-341968-uc8i9h0m	125	16	considered	consider	VBN
cord-341968-uc8i9h0m	125	17	polytropic	polytropic	NNP
cord-341968-uc8i9h0m	125	18	[	[	-LRB-
cord-341968-uc8i9h0m	125	19	58	58	CD
cord-341968-uc8i9h0m	125	20	]	]	-RRB-
cord-341968-uc8i9h0m	125	21	.	.	.
cord-341968-uc8i9h0m	126	1	Only	only	RB
cord-341968-uc8i9h0m	126	2	the	the	DT
cord-341968-uc8i9h0m	126	3	S2	s2	NN
cord-341968-uc8i9h0m	126	4	site	site	NN
cord-341968-uc8i9h0m	126	5	in	in	IN
cord-341968-uc8i9h0m	126	6	SARS	SARS	NNP
cord-341968-uc8i9h0m	126	7	-	-	HYPH
cord-341968-uc8i9h0m	126	8	CoV	CoV	NNP
cord-341968-uc8i9h0m	126	9	(	(	-LRB-
cord-341968-uc8i9h0m	126	10	severe	severe	JJ
cord-341968-uc8i9h0m	126	11	acute	acute	JJ
cord-341968-uc8i9h0m	126	12	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	126	13	syndrome	syndrome	NN
cord-341968-uc8i9h0m	126	14	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	126	15	)	)	-RRB-
cord-341968-uc8i9h0m	126	16	has	have	VBZ
cord-341968-uc8i9h0m	126	17	a	a	DT
cord-341968-uc8i9h0m	126	18	PC	pc	NN
cord-341968-uc8i9h0m	126	19	cleavage	cleavage	NN
cord-341968-uc8i9h0m	126	20	site	site	NN
cord-341968-uc8i9h0m	126	21	motif	motif	NN
cord-341968-uc8i9h0m	126	22	[	[	-LRB-
cord-341968-uc8i9h0m	126	23	54	54	CD
cord-341968-uc8i9h0m	126	24	,	,	,
cord-341968-uc8i9h0m	126	25	55	55	CD
cord-341968-uc8i9h0m	126	26	]	]	-RRB-
cord-341968-uc8i9h0m	126	27	.	.	.
cord-341968-uc8i9h0m	127	1	The	the	DT
cord-341968-uc8i9h0m	127	2	fact	fact	NN
cord-341968-uc8i9h0m	127	3	that	that	IN
cord-341968-uc8i9h0m	127	4	MERS	MERS	NNP
cord-341968-uc8i9h0m	127	5	-	-	HYPH
cord-341968-uc8i9h0m	127	6	CoV	CoV	NNP
cord-341968-uc8i9h0m	127	7	and	and	CC
cord-341968-uc8i9h0m	127	8	SARS	SARS	NNP
cord-341968-uc8i9h0m	127	9	-	-	HYPH
cord-341968-uc8i9h0m	127	10	CoV	CoV	NNP
cord-341968-uc8i9h0m	127	11	are	be	VBP
cord-341968-uc8i9h0m	127	12	highly	highly	RB
cord-341968-uc8i9h0m	127	13	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	127	14	,	,	,
cord-341968-uc8i9h0m	127	15	and	and	CC
cord-341968-uc8i9h0m	127	16	that	that	IN
cord-341968-uc8i9h0m	127	17	IBV	IBV	NNP
cord-341968-uc8i9h0m	127	18	-	-	HYPH
cord-341968-uc8i9h0m	127	19	Beaudette	Beaudette	NNP
cord-341968-uc8i9h0m	127	20	is	be	VBZ
cord-341968-uc8i9h0m	127	21	apathogenic	apathogenic	JJ
cord-341968-uc8i9h0m	127	22	is	be	VBZ
cord-341968-uc8i9h0m	127	23	in	in	IN
cord-341968-uc8i9h0m	127	24	line	line	NN
cord-341968-uc8i9h0m	127	25	with	with	IN
cord-341968-uc8i9h0m	127	26	these	these	DT
cord-341968-uc8i9h0m	127	27	viruses	virus	NNS
cord-341968-uc8i9h0m	127	28	reacting	react	VBG
cord-341968-uc8i9h0m	127	29	with	with	IN
cord-341968-uc8i9h0m	127	30	proteases	protease	NNS
cord-341968-uc8i9h0m	127	31	other	other	JJ
cord-341968-uc8i9h0m	127	32	than	than	IN
cord-341968-uc8i9h0m	127	33	the	the	DT
cord-341968-uc8i9h0m	127	34	PCs	pc	NNS
cord-341968-uc8i9h0m	127	35	[	[	-LRB-
cord-341968-uc8i9h0m	127	36	61	61	CD
cord-341968-uc8i9h0m	127	37	,	,	,
cord-341968-uc8i9h0m	127	38	62	62	CD
cord-341968-uc8i9h0m	127	39	]	]	-RRB-
cord-341968-uc8i9h0m	127	40	.	.	.
cord-341968-uc8i9h0m	128	1	TMPRSS2	TMPRSS2	NNP
cord-341968-uc8i9h0m	128	2	promotes	promote	VBZ
cord-341968-uc8i9h0m	128	3	SARS	SARS	NNP
cord-341968-uc8i9h0m	128	4	-	-	HYPH
cord-341968-uc8i9h0m	128	5	CoV	CoV	NNP
cord-341968-uc8i9h0m	128	6	and	and	CC
cord-341968-uc8i9h0m	128	7	MERS	MERS	NNP
cord-341968-uc8i9h0m	128	8	-	-	HYPH
cord-341968-uc8i9h0m	128	9	CoV	cov	NN
cord-341968-uc8i9h0m	128	10	infection	infection	NN
cord-341968-uc8i9h0m	128	11	in	in	IN
cord-341968-uc8i9h0m	128	12	vivo	vivo	NNP
cord-341968-uc8i9h0m	128	13	[	[	-LRB-
cord-341968-uc8i9h0m	128	14	63	63	CD
cord-341968-uc8i9h0m	128	15	]	]	-RRB-
cord-341968-uc8i9h0m	128	16	.	.	.
cord-341968-uc8i9h0m	129	1	The	the	DT
cord-341968-uc8i9h0m	129	2	engineering	engineering	NN
cord-341968-uc8i9h0m	129	3	of	of	IN
cord-341968-uc8i9h0m	129	4	PC	pc	NN
cord-341968-uc8i9h0m	129	5	specificity	specificity	NN
cord-341968-uc8i9h0m	129	6	at	at	IN
cord-341968-uc8i9h0m	129	7	the	the	DT
cord-341968-uc8i9h0m	129	8	cleavage	cleavage	NN
cord-341968-uc8i9h0m	129	9	sites	site	NNS
cord-341968-uc8i9h0m	129	10	of	of	IN
cord-341968-uc8i9h0m	129	11	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	129	12	S	s	NN
cord-341968-uc8i9h0m	129	13	proteins	protein	NNS
cord-341968-uc8i9h0m	129	14	can	can	MD
cord-341968-uc8i9h0m	129	15	modify	modify	VB
cord-341968-uc8i9h0m	129	16	the	the	DT
cord-341968-uc8i9h0m	129	17	virus	virus	NN
cord-341968-uc8i9h0m	129	18	tropism	tropism	NN
cord-341968-uc8i9h0m	129	19	and	and	CC
cord-341968-uc8i9h0m	129	20	virulence	virulence	NN
cord-341968-uc8i9h0m	129	21	[	[	-LRB-
cord-341968-uc8i9h0m	129	22	64	64	CD
cord-341968-uc8i9h0m	129	23	,	,	,
cord-341968-uc8i9h0m	129	24	65	65	CD
cord-341968-uc8i9h0m	129	25	]	]	-RRB-
cord-341968-uc8i9h0m	129	26	.	.	.
cord-341968-uc8i9h0m	130	1	The	the	DT
cord-341968-uc8i9h0m	130	2	conversion	conversion	NN
cord-341968-uc8i9h0m	130	3	of	of	IN
cord-341968-uc8i9h0m	130	4	a	a	DT
cord-341968-uc8i9h0m	130	5	monobasic	monobasic	JJ
cord-341968-uc8i9h0m	130	6	cleavage	cleavage	NN
cord-341968-uc8i9h0m	130	7	site	site	NN
cord-341968-uc8i9h0m	130	8	into	into	IN
cord-341968-uc8i9h0m	130	9	a	a	DT
cord-341968-uc8i9h0m	130	10	polybasic	polybasic	JJ
cord-341968-uc8i9h0m	130	11	site	site	NN
cord-341968-uc8i9h0m	130	12	not	not	RB
cord-341968-uc8i9h0m	130	13	only	only	RB
cord-341968-uc8i9h0m	130	14	makes	make	VBZ
cord-341968-uc8i9h0m	130	15	the	the	DT
cord-341968-uc8i9h0m	130	16	virus	virus	NN
cord-341968-uc8i9h0m	130	17	susceptible	susceptible	JJ
cord-341968-uc8i9h0m	130	18	to	to	IN
cord-341968-uc8i9h0m	130	19	PC	pc	NN
cord-341968-uc8i9h0m	130	20	cleavage	cleavage	NN
cord-341968-uc8i9h0m	130	21	but	but	CC
cord-341968-uc8i9h0m	130	22	also	also	RB
cord-341968-uc8i9h0m	130	23	increases	increase	VBZ
cord-341968-uc8i9h0m	130	24	the	the	DT
cord-341968-uc8i9h0m	130	25	chance	chance	NN
cord-341968-uc8i9h0m	130	26	of	of	IN
cord-341968-uc8i9h0m	130	27	cleavage	cleavage	NN
cord-341968-uc8i9h0m	130	28	by	by	IN
cord-341968-uc8i9h0m	130	29	other	other	JJ
cord-341968-uc8i9h0m	130	30	proteases	protease	NNS
cord-341968-uc8i9h0m	130	31	that	that	WDT
cord-341968-uc8i9h0m	130	32	target	target	VBP
cord-341968-uc8i9h0m	130	33	single	single	JJ
cord-341968-uc8i9h0m	130	34	arginine	arginine	NN
cord-341968-uc8i9h0m	130	35	residues	residue	NNS
cord-341968-uc8i9h0m	130	36	,	,	,
cord-341968-uc8i9h0m	130	37	so	so	CC
cord-341968-uc8i9h0m	130	38	it	-PRON-	PRP
cord-341968-uc8i9h0m	130	39	is	be	VBZ
cord-341968-uc8i9h0m	130	40	not	not	RB
cord-341968-uc8i9h0m	130	41	surprising	surprising	JJ
cord-341968-uc8i9h0m	130	42	that	that	IN
cord-341968-uc8i9h0m	130	43	MERS	MERS	NNP
cord-341968-uc8i9h0m	130	44	-	-	HYPH
cord-341968-uc8i9h0m	130	45	CoV	CoV	NNP
cord-341968-uc8i9h0m	130	46	is	be	VBZ
cord-341968-uc8i9h0m	130	47	so	so	RB
cord-341968-uc8i9h0m	130	48	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	130	49	.	.	.
cord-341968-uc8i9h0m	131	1	Because	because	IN
cord-341968-uc8i9h0m	131	2	coronaviruses	coronaviruse	NNS
cord-341968-uc8i9h0m	131	3	are	be	VBP
cord-341968-uc8i9h0m	131	4	adapted	adapt	VBN
cord-341968-uc8i9h0m	131	5	to	to	IN
cord-341968-uc8i9h0m	131	6	the	the	DT
cord-341968-uc8i9h0m	131	7	different	different	JJ
cord-341968-uc8i9h0m	131	8	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	131	9	environments	environment	NNS
cord-341968-uc8i9h0m	131	10	of	of	IN
cord-341968-uc8i9h0m	131	11	the	the	DT
cord-341968-uc8i9h0m	131	12	many	many	JJ
cord-341968-uc8i9h0m	131	13	cell	cell	NN
cord-341968-uc8i9h0m	131	14	types	type	NNS
cord-341968-uc8i9h0m	131	15	they	-PRON-	PRP
cord-341968-uc8i9h0m	131	16	infect	infect	VBP
cord-341968-uc8i9h0m	131	17	,	,	,
cord-341968-uc8i9h0m	131	18	each	each	DT
cord-341968-uc8i9h0m	131	19	virus	virus	NN
cord-341968-uc8i9h0m	131	20	may	may	MD
cord-341968-uc8i9h0m	131	21	be	be	VB
cord-341968-uc8i9h0m	131	22	activated	activate	VBN
cord-341968-uc8i9h0m	131	23	by	by	IN
cord-341968-uc8i9h0m	131	24	a	a	DT
cord-341968-uc8i9h0m	131	25	specific	specific	JJ
cord-341968-uc8i9h0m	131	26	set	set	NN
cord-341968-uc8i9h0m	131	27	of	of	IN
cord-341968-uc8i9h0m	131	28	proteases	protease	NNS
cord-341968-uc8i9h0m	131	29	.	.	.
cord-341968-uc8i9h0m	132	1	It	-PRON-	PRP
cord-341968-uc8i9h0m	132	2	is	be	VBZ
cord-341968-uc8i9h0m	132	3	crucial	crucial	JJ
cord-341968-uc8i9h0m	132	4	to	to	TO
cord-341968-uc8i9h0m	132	5	define	define	VB
cord-341968-uc8i9h0m	132	6	the	the	DT
cord-341968-uc8i9h0m	132	7	protease	protease	NN
cord-341968-uc8i9h0m	132	8	cleavage	cleavage	NN
cord-341968-uc8i9h0m	132	9	specificity	specificity	NN
cord-341968-uc8i9h0m	132	10	of	of	IN
cord-341968-uc8i9h0m	132	11	viruses	virus	NNS
cord-341968-uc8i9h0m	132	12	that	that	WDT
cord-341968-uc8i9h0m	132	13	impact	impact	VBP
cord-341968-uc8i9h0m	132	14	human	human	JJ
cord-341968-uc8i9h0m	132	15	or	or	CC
cord-341968-uc8i9h0m	132	16	animal	animal	NN
cord-341968-uc8i9h0m	132	17	health	health	NN
cord-341968-uc8i9h0m	132	18	.	.	.
cord-341968-uc8i9h0m	133	1	The	the	DT
cord-341968-uc8i9h0m	133	2	use	use	NN
cord-341968-uc8i9h0m	133	3	of	of	IN
cord-341968-uc8i9h0m	133	4	the	the	DT
cord-341968-uc8i9h0m	133	5	PC	pc	NN
cord-341968-uc8i9h0m	133	6	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	133	7	,	,	,
cord-341968-uc8i9h0m	133	8	dec	dec	NNP
cord-341968-uc8i9h0m	133	9	-	-	HYPH
cord-341968-uc8i9h0m	133	10	RVKR	RVKR	NNP
cord-341968-uc8i9h0m	133	11	-	-	HYPH
cord-341968-uc8i9h0m	133	12	cmk	cmk	NNP
cord-341968-uc8i9h0m	133	13	,	,	,
cord-341968-uc8i9h0m	133	14	has	have	VBZ
cord-341968-uc8i9h0m	133	15	created	create	VBN
cord-341968-uc8i9h0m	133	16	some	some	DT
cord-341968-uc8i9h0m	133	17	controversy	controversy	NN
cord-341968-uc8i9h0m	133	18	as	as	IN
cord-341968-uc8i9h0m	133	19	sometimes	sometimes	RB
cord-341968-uc8i9h0m	133	20	the	the	DT
cord-341968-uc8i9h0m	133	21	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	133	22	is	be	VBZ
cord-341968-uc8i9h0m	133	23	used	use	VBN
cord-341968-uc8i9h0m	133	24	in	in	IN
cord-341968-uc8i9h0m	133	25	excessive	excessive	JJ
cord-341968-uc8i9h0m	133	26	concentrations	concentration	NNS
cord-341968-uc8i9h0m	133	27	.	.	.
cord-341968-uc8i9h0m	134	1	The	the	DT
cord-341968-uc8i9h0m	134	2	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	134	3	binds	bind	VBZ
cord-341968-uc8i9h0m	134	4	PCs	pc	NNS
cord-341968-uc8i9h0m	134	5	with	with	IN
cord-341968-uc8i9h0m	134	6	a	a	DT
cord-341968-uc8i9h0m	134	7	very	very	RB
cord-341968-uc8i9h0m	134	8	high	high	JJ
cord-341968-uc8i9h0m	134	9	affinity	affinity	NN
cord-341968-uc8i9h0m	134	10	,	,	,
cord-341968-uc8i9h0m	134	11	at	at	IN
cord-341968-uc8i9h0m	134	12	low	low	JJ
cord-341968-uc8i9h0m	134	13	nM	nM	NNP
cord-341968-uc8i9h0m	134	14	concentrations	concentration	NNS
cord-341968-uc8i9h0m	134	15	;	;	:
cord-341968-uc8i9h0m	134	16	it	-PRON-	PRP
cord-341968-uc8i9h0m	134	17	slowly	slowly	RB
cord-341968-uc8i9h0m	134	18	forms	form	VBZ
cord-341968-uc8i9h0m	134	19	covalent	covalent	JJ
cord-341968-uc8i9h0m	134	20	complexes	complex	NNS
cord-341968-uc8i9h0m	134	21	with	with	IN
cord-341968-uc8i9h0m	134	22	the	the	DT
cord-341968-uc8i9h0m	134	23	enzymes	enzyme	NNS
cord-341968-uc8i9h0m	134	24	,	,	,
cord-341968-uc8i9h0m	134	25	so	so	IN
cord-341968-uc8i9h0m	134	26	it	-PRON-	PRP
cord-341968-uc8i9h0m	134	27	inhibits	inhibit	VBZ
cord-341968-uc8i9h0m	134	28	PCs	pc	NNS
cord-341968-uc8i9h0m	134	29	in	in	IN
cord-341968-uc8i9h0m	134	30	a	a	DT
cord-341968-uc8i9h0m	134	31	stoichiometric	stoichiometric	JJ
cord-341968-uc8i9h0m	134	32	manner	manner	NN
cord-341968-uc8i9h0m	134	33	.	.	.
cord-341968-uc8i9h0m	135	1	In	in	IN
cord-341968-uc8i9h0m	135	2	our	-PRON-	PRP$
cord-341968-uc8i9h0m	135	3	hands	hand	NNS
cord-341968-uc8i9h0m	135	4	,	,	,
cord-341968-uc8i9h0m	135	5	treating	treat	VBG
cord-341968-uc8i9h0m	135	6	cells	cell	NNS
cord-341968-uc8i9h0m	135	7	with	with	IN
cord-341968-uc8i9h0m	135	8	this	this	DT
cord-341968-uc8i9h0m	135	9	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	135	10	at	at	IN
cord-341968-uc8i9h0m	135	11	a	a	DT
cord-341968-uc8i9h0m	135	12	concentration	concentration	NN
cord-341968-uc8i9h0m	135	13	of	of	IN
cord-341968-uc8i9h0m	135	14	1	1	CD
cord-341968-uc8i9h0m	135	15	µM	µm	NN
cord-341968-uc8i9h0m	135	16	is	be	VBZ
cord-341968-uc8i9h0m	135	17	enough	enough	JJ
cord-341968-uc8i9h0m	135	18	to	to	TO
cord-341968-uc8i9h0m	135	19	block	block	VB
cord-341968-uc8i9h0m	135	20	HPV16	hpv16	NN
cord-341968-uc8i9h0m	135	21	cell	cell	NN
cord-341968-uc8i9h0m	135	22	entry	entry	NN
cord-341968-uc8i9h0m	135	23	completely	completely	RB
cord-341968-uc8i9h0m	135	24	.	.	.
cord-341968-uc8i9h0m	136	1	Concentrations	concentration	NNS
cord-341968-uc8i9h0m	136	2	up	up	IN
cord-341968-uc8i9h0m	136	3	to	to	IN
cord-341968-uc8i9h0m	136	4	100	100	CD
cord-341968-uc8i9h0m	137	1	µM	µm	CD
cord-341968-uc8i9h0m	137	2	reported	report	VBN
cord-341968-uc8i9h0m	137	3	in	in	IN
cord-341968-uc8i9h0m	137	4	some	some	DT
cord-341968-uc8i9h0m	137	5	studies	study	NNS
cord-341968-uc8i9h0m	137	6	should	should	MD
cord-341968-uc8i9h0m	137	7	not	not	RB
cord-341968-uc8i9h0m	137	8	be	be	VB
cord-341968-uc8i9h0m	137	9	considered	consider	VBN
cord-341968-uc8i9h0m	137	10	PC	pc	NN
cord-341968-uc8i9h0m	137	11	-	-	HYPH
cord-341968-uc8i9h0m	137	12	specific	specific	JJ
cord-341968-uc8i9h0m	137	13	;	;	:
cord-341968-uc8i9h0m	137	14	such	such	JJ
cord-341968-uc8i9h0m	137	15	high	high	JJ
cord-341968-uc8i9h0m	137	16	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	137	17	concentrations	concentration	NNS
cord-341968-uc8i9h0m	137	18	most	most	RBS
cord-341968-uc8i9h0m	137	19	probably	probably	RB
cord-341968-uc8i9h0m	137	20	inhibit	inhibit	VBP
cord-341968-uc8i9h0m	137	21	other	other	JJ
cord-341968-uc8i9h0m	137	22	proteases	protease	NNS
cord-341968-uc8i9h0m	137	23	besides	besides	IN
cord-341968-uc8i9h0m	137	24	PCs	pc	NNS
cord-341968-uc8i9h0m	137	25	[	[	-LRB-
cord-341968-uc8i9h0m	137	26	58	58	CD
cord-341968-uc8i9h0m	137	27	,	,	,
cord-341968-uc8i9h0m	137	28	64	64	CD
cord-341968-uc8i9h0m	137	29	]	]	-RRB-
cord-341968-uc8i9h0m	137	30	.	.	.
cord-341968-uc8i9h0m	138	1	Medically	medically	RB
cord-341968-uc8i9h0m	138	2	relevant	relevant	JJ
cord-341968-uc8i9h0m	138	3	retroviruses	retrovirus	NNS
cord-341968-uc8i9h0m	138	4	of	of	IN
cord-341968-uc8i9h0m	138	5	the	the	DT
cord-341968-uc8i9h0m	138	6	Retroviridae	Retroviridae	NNP
cord-341968-uc8i9h0m	138	7	family	family	NN
cord-341968-uc8i9h0m	138	8	have	have	VBP
cord-341968-uc8i9h0m	138	9	also	also	RB
cord-341968-uc8i9h0m	138	10	been	be	VBN
cord-341968-uc8i9h0m	138	11	studied	study	VBN
cord-341968-uc8i9h0m	138	12	concerning	concern	VBG
cord-341968-uc8i9h0m	138	13	their	-PRON-	PRP$
cord-341968-uc8i9h0m	138	14	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	138	15	regulation	regulation	NN
cord-341968-uc8i9h0m	138	16	.	.	.
cord-341968-uc8i9h0m	139	1	The	the	DT
cord-341968-uc8i9h0m	139	2	most	most	RBS
cord-341968-uc8i9h0m	139	3	studied	study	VBN
cord-341968-uc8i9h0m	139	4	viruses	virus	NNS
cord-341968-uc8i9h0m	139	5	are	be	VBP
cord-341968-uc8i9h0m	139	6	the	the	DT
cord-341968-uc8i9h0m	139	7	bovine	bovine	JJ
cord-341968-uc8i9h0m	139	8	and	and	CC
cord-341968-uc8i9h0m	139	9	murine	murine	JJ
cord-341968-uc8i9h0m	139	10	leukemia	leukemia	NN
cord-341968-uc8i9h0m	139	11	viruses	virus	NNS
cord-341968-uc8i9h0m	139	12	,	,	,
cord-341968-uc8i9h0m	139	13	which	which	WDT
cord-341968-uc8i9h0m	139	14	are	be	VBP
cord-341968-uc8i9h0m	139	15	related	relate	VBN
cord-341968-uc8i9h0m	139	16	to	to	IN
cord-341968-uc8i9h0m	139	17	the	the	DT
cord-341968-uc8i9h0m	139	18	human	human	JJ
cord-341968-uc8i9h0m	139	19	T	T	NNP
cord-341968-uc8i9h0m	139	20	-	-	HYPH
cord-341968-uc8i9h0m	139	21	lymphotropic	lymphotropic	NNP
cord-341968-uc8i9h0m	139	22	viruses	virus	NNS
cord-341968-uc8i9h0m	139	23	.	.	.
cord-341968-uc8i9h0m	140	1	Their	-PRON-	PRP$
cord-341968-uc8i9h0m	140	2	envelope	envelope	NN
cord-341968-uc8i9h0m	140	3	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	140	4	are	be	VBP
cord-341968-uc8i9h0m	140	5	cleaved	cleave	VBN
cord-341968-uc8i9h0m	140	6	by	by	IN
cord-341968-uc8i9h0m	140	7	furin	furin	NN
cord-341968-uc8i9h0m	140	8	and	and	CC
cord-341968-uc8i9h0m	140	9	other	other	JJ
cord-341968-uc8i9h0m	140	10	PCs	pc	NNS
cord-341968-uc8i9h0m	140	11	[	[	-LRB-
cord-341968-uc8i9h0m	140	12	66	66	CD
cord-341968-uc8i9h0m	140	13	]	]	-RRB-
cord-341968-uc8i9h0m	140	14	.	.	.
cord-341968-uc8i9h0m	141	1	Like	like	IN
cord-341968-uc8i9h0m	141	2	the	the	DT
cord-341968-uc8i9h0m	141	3	coronaviruses	coronaviruse	NNS
cord-341968-uc8i9h0m	141	4	,	,	,
cord-341968-uc8i9h0m	141	5	leukemia	leukemia	NN
cord-341968-uc8i9h0m	141	6	virus	virus	NN
cord-341968-uc8i9h0m	141	7	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	141	8	are	be	VBP
cord-341968-uc8i9h0m	141	9	cleaved	cleave	VBN
cord-341968-uc8i9h0m	141	10	twice	twice	RB
cord-341968-uc8i9h0m	141	11	.	.	.
cord-341968-uc8i9h0m	142	1	PCs	pc	NNS
cord-341968-uc8i9h0m	142	2	perform	perform	VBP
cord-341968-uc8i9h0m	142	3	the	the	DT
cord-341968-uc8i9h0m	142	4	first	first	JJ
cord-341968-uc8i9h0m	142	5	cleavage	cleavage	NN
cord-341968-uc8i9h0m	142	6	,	,	,
cord-341968-uc8i9h0m	142	7	which	which	WDT
cord-341968-uc8i9h0m	142	8	induces	induce	VBZ
cord-341968-uc8i9h0m	142	9	conformational	conformational	JJ
cord-341968-uc8i9h0m	142	10	changes	change	NNS
cord-341968-uc8i9h0m	142	11	and	and	CC
cord-341968-uc8i9h0m	142	12	disulfide	disulfide	NN
cord-341968-uc8i9h0m	142	13	isomerizations	isomerization	NNS
cord-341968-uc8i9h0m	142	14	that	that	WDT
cord-341968-uc8i9h0m	142	15	prime	prime	VBP
cord-341968-uc8i9h0m	142	16	the	the	DT
cord-341968-uc8i9h0m	142	17	protein	protein	NN
cord-341968-uc8i9h0m	142	18	for	for	IN
cord-341968-uc8i9h0m	142	19	further	further	JJ
cord-341968-uc8i9h0m	142	20	proteolysis	proteolysis	NN
cord-341968-uc8i9h0m	142	21	[	[	-LRB-
cord-341968-uc8i9h0m	142	22	67	67	CD
cord-341968-uc8i9h0m	142	23	,	,	,
cord-341968-uc8i9h0m	142	24	68	68	CD
cord-341968-uc8i9h0m	142	25	]	]	-RRB-
cord-341968-uc8i9h0m	142	26	.	.	.
cord-341968-uc8i9h0m	143	1	The	the	DT
cord-341968-uc8i9h0m	143	2	second	second	JJ
cord-341968-uc8i9h0m	143	3	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	143	4	event	event	NN
cord-341968-uc8i9h0m	143	5	is	be	VBZ
cord-341968-uc8i9h0m	143	6	performed	perform	VBN
cord-341968-uc8i9h0m	143	7	by	by	IN
cord-341968-uc8i9h0m	143	8	a	a	DT
cord-341968-uc8i9h0m	143	9	viral	viral	JJ
cord-341968-uc8i9h0m	143	10	protease	protease	NN
cord-341968-uc8i9h0m	143	11	that	that	WDT
cord-341968-uc8i9h0m	143	12	fully	fully	RB
cord-341968-uc8i9h0m	143	13	activates	activate	VBZ
cord-341968-uc8i9h0m	143	14	the	the	DT
cord-341968-uc8i9h0m	143	15	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	143	16	[	[	-LRB-
cord-341968-uc8i9h0m	143	17	69	69	CD
cord-341968-uc8i9h0m	143	18	,	,	,
cord-341968-uc8i9h0m	143	19	70	70	CD
cord-341968-uc8i9h0m	143	20	]	]	-RRB-
cord-341968-uc8i9h0m	143	21	.	.	.
cord-341968-uc8i9h0m	144	1	The	the	DT
cord-341968-uc8i9h0m	144	2	human	human	JJ
cord-341968-uc8i9h0m	144	3	immunodeficiency	immunodeficiency	NN
cord-341968-uc8i9h0m	144	4	virus	virus	NN
cord-341968-uc8i9h0m	144	5	(	(	-LRB-
cord-341968-uc8i9h0m	144	6	HIV	HIV	NNP
cord-341968-uc8i9h0m	144	7	)	)	-RRB-
cord-341968-uc8i9h0m	144	8	Env	Env	NNP
cord-341968-uc8i9h0m	144	9	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	144	10	gp160	gp160	NN
cord-341968-uc8i9h0m	144	11	precursor	precursor	NN
cord-341968-uc8i9h0m	144	12	is	be	VBZ
cord-341968-uc8i9h0m	144	13	cleaved	cleave	VBN
cord-341968-uc8i9h0m	144	14	by	by	IN
cord-341968-uc8i9h0m	144	15	furin	furin	NN
cord-341968-uc8i9h0m	144	16	during	during	IN
cord-341968-uc8i9h0m	144	17	biosynthesis	biosynthesis	NN
cord-341968-uc8i9h0m	144	18	into	into	IN
cord-341968-uc8i9h0m	144	19	gp120	gp120	NNP
cord-341968-uc8i9h0m	144	20	and	and	CC
cord-341968-uc8i9h0m	144	21	gp41	gp41	NN
cord-341968-uc8i9h0m	144	22	in	in	IN
cord-341968-uc8i9h0m	144	23	the	the	DT
cord-341968-uc8i9h0m	144	24	trans	trans	NNP
cord-341968-uc8i9h0m	144	25	-	-	NNP
cord-341968-uc8i9h0m	144	26	Golgi	Golgi	NNP
cord-341968-uc8i9h0m	144	27	network	network	NN
cord-341968-uc8i9h0m	144	28	(	(	-LRB-
cord-341968-uc8i9h0m	144	29	Figure	figure	NN
cord-341968-uc8i9h0m	144	30	2	2	CD
cord-341968-uc8i9h0m	144	31	)	)	-RRB-
cord-341968-uc8i9h0m	144	32	.	.	.
cord-341968-uc8i9h0m	145	1	gp120	gp120	NNP
cord-341968-uc8i9h0m	145	2	is	be	VBZ
cord-341968-uc8i9h0m	145	3	further	far	RBR
cord-341968-uc8i9h0m	145	4	processed	process	VBN
cord-341968-uc8i9h0m	145	5	by	by	IN
cord-341968-uc8i9h0m	145	6	furin	furin	NN
cord-341968-uc8i9h0m	145	7	into	into	IN
cord-341968-uc8i9h0m	145	8	gp77	gp77	NNP
cord-341968-uc8i9h0m	145	9	and	and	CC
cord-341968-uc8i9h0m	145	10	gp53	gp53	NNS
cord-341968-uc8i9h0m	145	11	after	after	IN
cord-341968-uc8i9h0m	145	12	leaving	leave	VBG
cord-341968-uc8i9h0m	145	13	the	the	DT
cord-341968-uc8i9h0m	145	14	TGN	TGN	NNP
cord-341968-uc8i9h0m	145	15	[	[	-LRB-
cord-341968-uc8i9h0m	145	16	71	71	CD
cord-341968-uc8i9h0m	145	17	,	,	,
cord-341968-uc8i9h0m	145	18	72	72	CD
cord-341968-uc8i9h0m	145	19	]	]	-RRB-
cord-341968-uc8i9h0m	145	20	.	.	.
cord-341968-uc8i9h0m	146	1	The	the	DT
cord-341968-uc8i9h0m	146	2	Env	Env	NNP
cord-341968-uc8i9h0m	146	3	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	146	4	is	be	VBZ
cord-341968-uc8i9h0m	146	5	the	the	DT
cord-341968-uc8i9h0m	146	6	only	only	JJ
cord-341968-uc8i9h0m	146	7	antigenic	antigenic	JJ
cord-341968-uc8i9h0m	146	8	HIV	HIV	NNP
cord-341968-uc8i9h0m	146	9	protein	protein	NN
cord-341968-uc8i9h0m	146	10	,	,	,
cord-341968-uc8i9h0m	146	11	and	and	CC
cord-341968-uc8i9h0m	146	12	furin	furin	NN
cord-341968-uc8i9h0m	146	13	cleavage	cleavage	NN
cord-341968-uc8i9h0m	146	14	-	-	HYPH
cord-341968-uc8i9h0m	146	15	independent	independent	JJ
cord-341968-uc8i9h0m	146	16	forms	form	NNS
cord-341968-uc8i9h0m	146	17	stabilized	stabilize	VBN
cord-341968-uc8i9h0m	146	18	in	in	IN
cord-341968-uc8i9h0m	146	19	the	the	DT
cord-341968-uc8i9h0m	146	20	native	native	JJ
cord-341968-uc8i9h0m	146	21	form	form	NN
cord-341968-uc8i9h0m	146	22	have	have	VBP
cord-341968-uc8i9h0m	146	23	been	be	VBN
cord-341968-uc8i9h0m	146	24	produced	produce	VBN
cord-341968-uc8i9h0m	146	25	for	for	IN
cord-341968-uc8i9h0m	146	26	vaccine	vaccine	NN
cord-341968-uc8i9h0m	146	27	development	development	NN
cord-341968-uc8i9h0m	146	28	purposes	purpose	NNS
cord-341968-uc8i9h0m	146	29	[	[	-LRB-
cord-341968-uc8i9h0m	146	30	73	73	CD
cord-341968-uc8i9h0m	146	31	]	]	-RRB-
cord-341968-uc8i9h0m	146	32	.	.	.
cord-341968-uc8i9h0m	147	1	Interestingly	interestingly	RB
cord-341968-uc8i9h0m	147	2	,	,	,
cord-341968-uc8i9h0m	147	3	a	a	DT
cord-341968-uc8i9h0m	147	4	polybasic	polybasic	JJ
cord-341968-uc8i9h0m	147	5	region	region	NN
cord-341968-uc8i9h0m	147	6	located	locate	VBN
cord-341968-uc8i9h0m	147	7	upstream	upstream	RB
cord-341968-uc8i9h0m	147	8	from	from	IN
cord-341968-uc8i9h0m	147	9	the	the	DT
cord-341968-uc8i9h0m	147	10	PC	pc	NN
cord-341968-uc8i9h0m	147	11	cleavage	cleavage	NN
cord-341968-uc8i9h0m	147	12	site	site	NN
cord-341968-uc8i9h0m	147	13	at	at	IN
cord-341968-uc8i9h0m	147	14	the	the	DT
cord-341968-uc8i9h0m	147	15	gp120	gp120	NNP
cord-341968-uc8i9h0m	147	16	/	/	SYM
cord-341968-uc8i9h0m	147	17	gp41	gp41	NNP
cord-341968-uc8i9h0m	147	18	junction	junction	NN
cord-341968-uc8i9h0m	147	19	was	be	VBD
cord-341968-uc8i9h0m	147	20	shown	show	VBN
cord-341968-uc8i9h0m	147	21	to	to	TO
cord-341968-uc8i9h0m	147	22	bind	bind	VB
cord-341968-uc8i9h0m	147	23	heparin	heparin	NN
cord-341968-uc8i9h0m	147	24	and	and	CC
cord-341968-uc8i9h0m	147	25	promote	promote	VB
cord-341968-uc8i9h0m	147	26	cleavage	cleavage	NN
cord-341968-uc8i9h0m	147	27	[	[	-LRB-
cord-341968-uc8i9h0m	147	28	74	74	CD
cord-341968-uc8i9h0m	147	29	]	]	-RRB-
cord-341968-uc8i9h0m	147	30	.	.	.
cord-341968-uc8i9h0m	148	1	Medically	medically	RB
cord-341968-uc8i9h0m	148	2	relevant	relevant	JJ
cord-341968-uc8i9h0m	148	3	retroviruses	retrovirus	NNS
cord-341968-uc8i9h0m	148	4	of	of	IN
cord-341968-uc8i9h0m	148	5	the	the	DT
cord-341968-uc8i9h0m	148	6	Retroviridae	Retroviridae	NNP
cord-341968-uc8i9h0m	148	7	family	family	NN
cord-341968-uc8i9h0m	148	8	have	have	VBP
cord-341968-uc8i9h0m	148	9	also	also	RB
cord-341968-uc8i9h0m	148	10	been	be	VBN
cord-341968-uc8i9h0m	148	11	studied	study	VBN
cord-341968-uc8i9h0m	148	12	concerning	concern	VBG
cord-341968-uc8i9h0m	148	13	their	-PRON-	PRP$
cord-341968-uc8i9h0m	148	14	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	148	15	regulation	regulation	NN
cord-341968-uc8i9h0m	148	16	.	.	.
cord-341968-uc8i9h0m	149	1	The	the	DT
cord-341968-uc8i9h0m	149	2	most	most	RBS
cord-341968-uc8i9h0m	149	3	studied	study	VBN
cord-341968-uc8i9h0m	149	4	viruses	virus	NNS
cord-341968-uc8i9h0m	149	5	are	be	VBP
cord-341968-uc8i9h0m	149	6	the	the	DT
cord-341968-uc8i9h0m	149	7	bovine	bovine	JJ
cord-341968-uc8i9h0m	149	8	and	and	CC
cord-341968-uc8i9h0m	149	9	murine	murine	JJ
cord-341968-uc8i9h0m	149	10	leukemia	leukemia	NN
cord-341968-uc8i9h0m	149	11	viruses	virus	NNS
cord-341968-uc8i9h0m	149	12	,	,	,
cord-341968-uc8i9h0m	149	13	which	which	WDT
cord-341968-uc8i9h0m	149	14	are	be	VBP
cord-341968-uc8i9h0m	149	15	related	relate	VBN
cord-341968-uc8i9h0m	149	16	to	to	IN
cord-341968-uc8i9h0m	149	17	the	the	DT
cord-341968-uc8i9h0m	149	18	human	human	JJ
cord-341968-uc8i9h0m	149	19	T	T	NNP
cord-341968-uc8i9h0m	149	20	-	-	HYPH
cord-341968-uc8i9h0m	149	21	lymphotropic	lymphotropic	NNP
cord-341968-uc8i9h0m	149	22	viruses	virus	NNS
cord-341968-uc8i9h0m	149	23	.	.	.
cord-341968-uc8i9h0m	150	1	Their	-PRON-	PRP$
cord-341968-uc8i9h0m	150	2	envelope	envelope	NN
cord-341968-uc8i9h0m	150	3	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	150	4	are	be	VBP
cord-341968-uc8i9h0m	150	5	cleaved	cleave	VBN
cord-341968-uc8i9h0m	150	6	by	by	IN
cord-341968-uc8i9h0m	150	7	furin	furin	NN
cord-341968-uc8i9h0m	150	8	and	and	CC
cord-341968-uc8i9h0m	150	9	other	other	JJ
cord-341968-uc8i9h0m	150	10	PCs	pc	NNS
cord-341968-uc8i9h0m	150	11	[	[	-LRB-
cord-341968-uc8i9h0m	150	12	66	66	CD
cord-341968-uc8i9h0m	150	13	]	]	-RRB-
cord-341968-uc8i9h0m	150	14	.	.	.
cord-341968-uc8i9h0m	151	1	Like	like	IN
cord-341968-uc8i9h0m	151	2	the	the	DT
cord-341968-uc8i9h0m	151	3	coronaviruses	coronaviruse	NNS
cord-341968-uc8i9h0m	151	4	,	,	,
cord-341968-uc8i9h0m	151	5	leukemia	leukemia	NN
cord-341968-uc8i9h0m	151	6	virus	virus	NN
cord-341968-uc8i9h0m	151	7	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	151	8	are	be	VBP
cord-341968-uc8i9h0m	151	9	cleaved	cleave	VBN
cord-341968-uc8i9h0m	151	10	twice	twice	RB
cord-341968-uc8i9h0m	151	11	.	.	.
cord-341968-uc8i9h0m	152	1	PCs	pc	NNS
cord-341968-uc8i9h0m	152	2	perform	perform	VBP
cord-341968-uc8i9h0m	152	3	the	the	DT
cord-341968-uc8i9h0m	152	4	first	first	JJ
cord-341968-uc8i9h0m	152	5	cleavage	cleavage	NN
cord-341968-uc8i9h0m	152	6	,	,	,
cord-341968-uc8i9h0m	152	7	which	which	WDT
cord-341968-uc8i9h0m	152	8	induces	induce	VBZ
cord-341968-uc8i9h0m	152	9	conformational	conformational	JJ
cord-341968-uc8i9h0m	152	10	changes	change	NNS
cord-341968-uc8i9h0m	152	11	and	and	CC
cord-341968-uc8i9h0m	152	12	disulfide	disulfide	NN
cord-341968-uc8i9h0m	152	13	isomerizations	isomerization	NNS
cord-341968-uc8i9h0m	152	14	that	that	WDT
cord-341968-uc8i9h0m	152	15	prime	prime	VBP
cord-341968-uc8i9h0m	152	16	the	the	DT
cord-341968-uc8i9h0m	152	17	protein	protein	NN
cord-341968-uc8i9h0m	152	18	for	for	IN
cord-341968-uc8i9h0m	152	19	further	further	JJ
cord-341968-uc8i9h0m	152	20	proteolysis	proteolysis	NN
cord-341968-uc8i9h0m	152	21	[	[	-LRB-
cord-341968-uc8i9h0m	152	22	67	67	CD
cord-341968-uc8i9h0m	152	23	,	,	,
cord-341968-uc8i9h0m	152	24	68	68	CD
cord-341968-uc8i9h0m	152	25	]	]	-RRB-
cord-341968-uc8i9h0m	152	26	.	.	.
cord-341968-uc8i9h0m	153	1	The	the	DT
cord-341968-uc8i9h0m	153	2	second	second	JJ
cord-341968-uc8i9h0m	153	3	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	153	4	event	event	NN
cord-341968-uc8i9h0m	153	5	is	be	VBZ
cord-341968-uc8i9h0m	153	6	performed	perform	VBN
cord-341968-uc8i9h0m	153	7	by	by	IN
cord-341968-uc8i9h0m	153	8	a	a	DT
cord-341968-uc8i9h0m	153	9	viral	viral	JJ
cord-341968-uc8i9h0m	153	10	protease	protease	NN
cord-341968-uc8i9h0m	153	11	that	that	WDT
cord-341968-uc8i9h0m	153	12	fully	fully	RB
cord-341968-uc8i9h0m	153	13	activates	activate	VBZ
cord-341968-uc8i9h0m	153	14	the	the	DT
cord-341968-uc8i9h0m	153	15	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	153	16	[	[	-LRB-
cord-341968-uc8i9h0m	153	17	69	69	CD
cord-341968-uc8i9h0m	153	18	,	,	,
cord-341968-uc8i9h0m	153	19	70	70	CD
cord-341968-uc8i9h0m	153	20	]	]	-RRB-
cord-341968-uc8i9h0m	153	21	.	.	.
cord-341968-uc8i9h0m	154	1	The	the	DT
cord-341968-uc8i9h0m	154	2	human	human	JJ
cord-341968-uc8i9h0m	154	3	immunodeficiency	immunodeficiency	NN
cord-341968-uc8i9h0m	154	4	virus	virus	NN
cord-341968-uc8i9h0m	154	5	(	(	-LRB-
cord-341968-uc8i9h0m	154	6	HIV	HIV	NNP
cord-341968-uc8i9h0m	154	7	)	)	-RRB-
cord-341968-uc8i9h0m	154	8	Env	Env	NNP
cord-341968-uc8i9h0m	154	9	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	154	10	gp160	gp160	NN
cord-341968-uc8i9h0m	154	11	precursor	precursor	NN
cord-341968-uc8i9h0m	154	12	is	be	VBZ
cord-341968-uc8i9h0m	154	13	cleaved	cleave	VBN
cord-341968-uc8i9h0m	154	14	by	by	IN
cord-341968-uc8i9h0m	154	15	furin	furin	NN
cord-341968-uc8i9h0m	154	16	during	during	IN
cord-341968-uc8i9h0m	154	17	biosynthesis	biosynthesis	NN
cord-341968-uc8i9h0m	154	18	into	into	IN
cord-341968-uc8i9h0m	154	19	gp120	gp120	NNP
cord-341968-uc8i9h0m	154	20	and	and	CC
cord-341968-uc8i9h0m	154	21	gp41	gp41	NN
cord-341968-uc8i9h0m	154	22	in	in	IN
cord-341968-uc8i9h0m	154	23	the	the	DT
cord-341968-uc8i9h0m	154	24	trans	trans	NNP
cord-341968-uc8i9h0m	154	25	-	-	NNP
cord-341968-uc8i9h0m	154	26	Golgi	Golgi	NNP
cord-341968-uc8i9h0m	154	27	network	network	NN
cord-341968-uc8i9h0m	154	28	(	(	-LRB-
cord-341968-uc8i9h0m	154	29	Figure	figure	NN
cord-341968-uc8i9h0m	154	30	2	2	CD
cord-341968-uc8i9h0m	154	31	)	)	-RRB-
cord-341968-uc8i9h0m	154	32	.	.	.
cord-341968-uc8i9h0m	155	1	gp120	gp120	NNP
cord-341968-uc8i9h0m	155	2	is	be	VBZ
cord-341968-uc8i9h0m	155	3	further	far	RBR
cord-341968-uc8i9h0m	155	4	processed	process	VBN
cord-341968-uc8i9h0m	155	5	by	by	IN
cord-341968-uc8i9h0m	155	6	furin	furin	NN
cord-341968-uc8i9h0m	155	7	into	into	IN
cord-341968-uc8i9h0m	155	8	gp77	gp77	NNP
cord-341968-uc8i9h0m	155	9	and	and	CC
cord-341968-uc8i9h0m	155	10	gp53	gp53	NNS
cord-341968-uc8i9h0m	155	11	after	after	IN
cord-341968-uc8i9h0m	155	12	leaving	leave	VBG
cord-341968-uc8i9h0m	155	13	the	the	DT
cord-341968-uc8i9h0m	155	14	TGN	TGN	NNP
cord-341968-uc8i9h0m	155	15	[	[	-LRB-
cord-341968-uc8i9h0m	155	16	71	71	CD
cord-341968-uc8i9h0m	155	17	,	,	,
cord-341968-uc8i9h0m	155	18	72	72	CD
cord-341968-uc8i9h0m	155	19	]	]	-RRB-
cord-341968-uc8i9h0m	155	20	.	.	.
cord-341968-uc8i9h0m	156	1	The	the	DT
cord-341968-uc8i9h0m	156	2	Env	Env	NNP
cord-341968-uc8i9h0m	156	3	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	156	4	is	be	VBZ
cord-341968-uc8i9h0m	156	5	the	the	DT
cord-341968-uc8i9h0m	156	6	only	only	JJ
cord-341968-uc8i9h0m	156	7	antigenic	antigenic	JJ
cord-341968-uc8i9h0m	156	8	HIV	HIV	NNP
cord-341968-uc8i9h0m	156	9	protein	protein	NN
cord-341968-uc8i9h0m	156	10	,	,	,
cord-341968-uc8i9h0m	156	11	and	and	CC
cord-341968-uc8i9h0m	156	12	furin	furin	NN
cord-341968-uc8i9h0m	156	13	cleavage	cleavage	NN
cord-341968-uc8i9h0m	156	14	-	-	HYPH
cord-341968-uc8i9h0m	156	15	independent	independent	JJ
cord-341968-uc8i9h0m	156	16	forms	form	NNS
cord-341968-uc8i9h0m	156	17	stabilized	stabilize	VBN
cord-341968-uc8i9h0m	156	18	in	in	IN
cord-341968-uc8i9h0m	156	19	the	the	DT
cord-341968-uc8i9h0m	156	20	native	native	JJ
cord-341968-uc8i9h0m	156	21	form	form	NN
cord-341968-uc8i9h0m	156	22	have	have	VBP
cord-341968-uc8i9h0m	156	23	been	be	VBN
cord-341968-uc8i9h0m	156	24	produced	produce	VBN
cord-341968-uc8i9h0m	156	25	for	for	IN
cord-341968-uc8i9h0m	156	26	vaccine	vaccine	NN
cord-341968-uc8i9h0m	156	27	development	development	NN
cord-341968-uc8i9h0m	156	28	purposes	purpose	NNS
cord-341968-uc8i9h0m	156	29	[	[	-LRB-
cord-341968-uc8i9h0m	156	30	73	73	CD
cord-341968-uc8i9h0m	156	31	]	]	-RRB-
cord-341968-uc8i9h0m	156	32	.	.	.
cord-341968-uc8i9h0m	157	1	Interestingly	interestingly	RB
cord-341968-uc8i9h0m	157	2	,	,	,
cord-341968-uc8i9h0m	157	3	a	a	DT
cord-341968-uc8i9h0m	157	4	polybasic	polybasic	JJ
cord-341968-uc8i9h0m	157	5	region	region	NN
cord-341968-uc8i9h0m	157	6	located	locate	VBN
cord-341968-uc8i9h0m	157	7	upstream	upstream	RB
cord-341968-uc8i9h0m	157	8	from	from	IN
cord-341968-uc8i9h0m	157	9	the	the	DT
cord-341968-uc8i9h0m	157	10	PC	pc	NN
cord-341968-uc8i9h0m	157	11	cleavage	cleavage	NN
cord-341968-uc8i9h0m	157	12	site	site	NN
cord-341968-uc8i9h0m	157	13	at	at	IN
cord-341968-uc8i9h0m	157	14	the	the	DT
cord-341968-uc8i9h0m	157	15	gp120	gp120	NNP
cord-341968-uc8i9h0m	157	16	/	/	SYM
cord-341968-uc8i9h0m	157	17	gp41	gp41	NNP
cord-341968-uc8i9h0m	157	18	junction	junction	NN
cord-341968-uc8i9h0m	157	19	was	be	VBD
cord-341968-uc8i9h0m	157	20	shown	show	VBN
cord-341968-uc8i9h0m	157	21	to	to	TO
cord-341968-uc8i9h0m	157	22	bind	bind	VB
cord-341968-uc8i9h0m	157	23	heparin	heparin	NN
cord-341968-uc8i9h0m	157	24	and	and	CC
cord-341968-uc8i9h0m	157	25	promote	promote	VB
cord-341968-uc8i9h0m	157	26	cleavage	cleavage	NN
cord-341968-uc8i9h0m	157	27	[	[	-LRB-
cord-341968-uc8i9h0m	157	28	74	74	CD
cord-341968-uc8i9h0m	157	29	]	]	-RRB-
cord-341968-uc8i9h0m	157	30	.	.	.
cord-341968-uc8i9h0m	158	1	Figure	figure	NN
cord-341968-uc8i9h0m	158	2	2	2	CD
cord-341968-uc8i9h0m	158	3	.	.	.
cord-341968-uc8i9h0m	159	1	X	x	NN
cord-341968-uc8i9h0m	159	2	-	-	NN
cord-341968-uc8i9h0m	159	3	ray	ray	NN
cord-341968-uc8i9h0m	159	4	crystal	crystal	NN
cord-341968-uc8i9h0m	159	5	structure	structure	NN
cord-341968-uc8i9h0m	159	6	of	of	IN
cord-341968-uc8i9h0m	159	7	the	the	DT
cord-341968-uc8i9h0m	159	8	HIV-1	HIV-1	NNP
cord-341968-uc8i9h0m	159	9	envelope	envelope	NN
cord-341968-uc8i9h0m	159	10	pg160	pg160	NN
cord-341968-uc8i9h0m	159	11	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	159	12	monomer	monomer	NN
cord-341968-uc8i9h0m	159	13	.	.	.
cord-341968-uc8i9h0m	160	1	The	the	DT
cord-341968-uc8i9h0m	160	2	fusion	fusion	NN
cord-341968-uc8i9h0m	160	3	machine	machine	NN
cord-341968-uc8i9h0m	160	4	is	be	VBZ
cord-341968-uc8i9h0m	160	5	composed	compose	VBN
cord-341968-uc8i9h0m	160	6	of	of	IN
cord-341968-uc8i9h0m	160	7	three	three	CD
cord-341968-uc8i9h0m	160	8	gp160	gp160	NNP
cord-341968-uc8i9h0m	160	9	monomers	monomer	NNS
cord-341968-uc8i9h0m	160	10	which	which	WDT
cord-341968-uc8i9h0m	160	11	are	be	VBP
cord-341968-uc8i9h0m	160	12	divided	divide	VBN
cord-341968-uc8i9h0m	160	13	into	into	IN
cord-341968-uc8i9h0m	160	14	N	n	CD
cord-341968-uc8i9h0m	160	15	-	-	HYPH
cord-341968-uc8i9h0m	160	16	terminal	terminal	NN
cord-341968-uc8i9h0m	160	17	gp120	gp120	CD
cord-341968-uc8i9h0m	160	18	(	(	-LRB-
cord-341968-uc8i9h0m	160	19	green	green	NNP
cord-341968-uc8i9h0m	160	20	)	)	-RRB-
cord-341968-uc8i9h0m	160	21	and	and	CC
cord-341968-uc8i9h0m	160	22	C	c	NN
cord-341968-uc8i9h0m	160	23	-	-	HYPH
cord-341968-uc8i9h0m	160	24	terminal	terminal	NN
cord-341968-uc8i9h0m	160	25	pg41	pg41	NNP
cord-341968-uc8i9h0m	160	26	(	(	-LRB-
cord-341968-uc8i9h0m	160	27	gray	gray	NNP
cord-341968-uc8i9h0m	160	28	)	)	-RRB-
cord-341968-uc8i9h0m	160	29	.	.	.
cord-341968-uc8i9h0m	161	1	Residue	residue	NN
cord-341968-uc8i9h0m	161	2	in	in	IN
cord-341968-uc8i9h0m	161	3	red	red	JJ
cord-341968-uc8i9h0m	161	4	denotes	denote	VBZ
cord-341968-uc8i9h0m	161	5	the	the	DT
cord-341968-uc8i9h0m	161	6	end	end	NN
cord-341968-uc8i9h0m	161	7	of	of	IN
cord-341968-uc8i9h0m	161	8	gp120	gp120	NN
cord-341968-uc8i9h0m	161	9	and	and	CC
cord-341968-uc8i9h0m	161	10	residue	residue	NN
cord-341968-uc8i9h0m	161	11	in	in	IN
cord-341968-uc8i9h0m	161	12	blue	blue	JJ
cord-341968-uc8i9h0m	161	13	the	the	DT
cord-341968-uc8i9h0m	161	14	beginning	beginning	NN
cord-341968-uc8i9h0m	161	15	of	of	IN
cord-341968-uc8i9h0m	161	16	gp41	gp41	NNP
cord-341968-uc8i9h0m	161	17	after	after	IN
cord-341968-uc8i9h0m	161	18	PC	pc	NN
cord-341968-uc8i9h0m	161	19	cleavage	cleavage	NN
cord-341968-uc8i9h0m	161	20	.	.	.
cord-341968-uc8i9h0m	162	1	PDB	PDB	NNP
cord-341968-uc8i9h0m	162	2	ID	ID	NNP
cord-341968-uc8i9h0m	162	3	code	code	NN
cord-341968-uc8i9h0m	162	4	6MTJ	6mtj	UH
cord-341968-uc8i9h0m	162	5	.	.	.
cord-341968-uc8i9h0m	163	1	The	the	DT
cord-341968-uc8i9h0m	163	2	duck	duck	NN
cord-341968-uc8i9h0m	163	3	hepatitis	hepatitis	NN
cord-341968-uc8i9h0m	163	4	B	b	NN
cord-341968-uc8i9h0m	163	5	virus	virus	NN
cord-341968-uc8i9h0m	163	6	(	(	-LRB-
cord-341968-uc8i9h0m	163	7	DHBV	DHBV	NNP
cord-341968-uc8i9h0m	163	8	)	)	-RRB-
cord-341968-uc8i9h0m	163	9	has	have	VBZ
cord-341968-uc8i9h0m	163	10	been	be	VBN
cord-341968-uc8i9h0m	163	11	used	use	VBN
cord-341968-uc8i9h0m	163	12	as	as	IN
cord-341968-uc8i9h0m	163	13	a	a	DT
cord-341968-uc8i9h0m	163	14	model	model	NN
cord-341968-uc8i9h0m	163	15	to	to	TO
cord-341968-uc8i9h0m	163	16	study	study	VB
cord-341968-uc8i9h0m	163	17	the	the	DT
cord-341968-uc8i9h0m	163	18	hepatitis	hepatitis	NN
cord-341968-uc8i9h0m	163	19	B	B	NNP
cord-341968-uc8i9h0m	163	20	virus	virus	NN
cord-341968-uc8i9h0m	163	21	(	(	-LRB-
cord-341968-uc8i9h0m	163	22	HBV	HBV	NNP
cord-341968-uc8i9h0m	163	23	)	)	-RRB-
cord-341968-uc8i9h0m	163	24	.	.	.
cord-341968-uc8i9h0m	164	1	The	the	DT
cord-341968-uc8i9h0m	164	2	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	164	3	events	event	NNS
cord-341968-uc8i9h0m	164	4	that	that	WDT
cord-341968-uc8i9h0m	164	5	regulate	regulate	VBP
cord-341968-uc8i9h0m	164	6	the	the	DT
cord-341968-uc8i9h0m	164	7	cell	cell	NN
cord-341968-uc8i9h0m	164	8	entry	entry	NN
cord-341968-uc8i9h0m	164	9	mechanism	mechanism	NN
cord-341968-uc8i9h0m	164	10	of	of	IN
cord-341968-uc8i9h0m	164	11	this	this	DT
cord-341968-uc8i9h0m	164	12	hepadnavirus	hepadnavirus	NN
cord-341968-uc8i9h0m	164	13	have	have	VBP
cord-341968-uc8i9h0m	164	14	not	not	RB
cord-341968-uc8i9h0m	164	15	attracted	attract	VBN
cord-341968-uc8i9h0m	164	16	much	much	JJ
cord-341968-uc8i9h0m	164	17	attention	attention	NN
cord-341968-uc8i9h0m	164	18	,	,	,
cord-341968-uc8i9h0m	164	19	but	but	CC
cord-341968-uc8i9h0m	164	20	there	there	EX
cord-341968-uc8i9h0m	164	21	is	be	VBZ
cord-341968-uc8i9h0m	164	22	evidence	evidence	NN
cord-341968-uc8i9h0m	164	23	of	of	IN
cord-341968-uc8i9h0m	164	24	the	the	DT
cord-341968-uc8i9h0m	164	25	cleavage	cleavage	NN
cord-341968-uc8i9h0m	164	26	of	of	IN
cord-341968-uc8i9h0m	164	27	the	the	DT
cord-341968-uc8i9h0m	164	28	envelope	envelope	NN
cord-341968-uc8i9h0m	164	29	proteins	protein	NNS
cord-341968-uc8i9h0m	164	30	by	by	IN
cord-341968-uc8i9h0m	164	31	PCs	pc	NNS
cord-341968-uc8i9h0m	164	32	[	[	-LRB-
cord-341968-uc8i9h0m	164	33	75	75	CD
cord-341968-uc8i9h0m	164	34	]	]	-RRB-
cord-341968-uc8i9h0m	164	35	.	.	.
cord-341968-uc8i9h0m	165	1	Single	single	JJ
cord-341968-uc8i9h0m	165	2	-	-	HYPH
cord-341968-uc8i9h0m	165	3	stranded	strand	VBN
cord-341968-uc8i9h0m	165	4	negative	negative	JJ
cord-341968-uc8i9h0m	165	5	-	-	HYPH
cord-341968-uc8i9h0m	165	6	sense	sense	NN
cord-341968-uc8i9h0m	165	7	RNA	RNA	NNP
cord-341968-uc8i9h0m	165	8	viruses	virus	NNS
cord-341968-uc8i9h0m	165	9	of	of	IN
cord-341968-uc8i9h0m	165	10	the	the	DT
cord-341968-uc8i9h0m	165	11	Filoviridae	Filoviridae	NNP
cord-341968-uc8i9h0m	165	12	and	and	CC
cord-341968-uc8i9h0m	165	13	Arenaviridae	Arenaviridae	NNP
cord-341968-uc8i9h0m	165	14	families	family	NNS
cord-341968-uc8i9h0m	165	15	and	and	CC
cord-341968-uc8i9h0m	165	16	the	the	DT
cord-341968-uc8i9h0m	165	17	new	new	JJ
cord-341968-uc8i9h0m	165	18	-	-	HYPH
cord-341968-uc8i9h0m	165	19	order	order	NN
cord-341968-uc8i9h0m	165	20	Bunyavirales	Bunyavirales	NNP
cord-341968-uc8i9h0m	165	21	are	be	VBP
cord-341968-uc8i9h0m	165	22	the	the	DT
cord-341968-uc8i9h0m	165	23	causative	causative	JJ
cord-341968-uc8i9h0m	165	24	agents	agent	NNS
cord-341968-uc8i9h0m	165	25	of	of	IN
cord-341968-uc8i9h0m	165	26	lethal	lethal	JJ
cord-341968-uc8i9h0m	165	27	hemorrhagic	hemorrhagic	JJ
cord-341968-uc8i9h0m	165	28	fever	fever	NN
cord-341968-uc8i9h0m	165	29	diseases	disease	NNS
cord-341968-uc8i9h0m	165	30	.	.	.
cord-341968-uc8i9h0m	166	1	Despite	despite	IN
cord-341968-uc8i9h0m	166	2	the	the	DT
cord-341968-uc8i9h0m	166	3	seriousness	seriousness	NN
cord-341968-uc8i9h0m	166	4	of	of	IN
cord-341968-uc8i9h0m	166	5	the	the	DT
cord-341968-uc8i9h0m	166	6	health	health	NN
cord-341968-uc8i9h0m	166	7	threat	threat	NN
cord-341968-uc8i9h0m	166	8	these	these	DT
cord-341968-uc8i9h0m	166	9	viruses	virus	NNS
cord-341968-uc8i9h0m	166	10	represent	represent	VBP
cord-341968-uc8i9h0m	166	11	,	,	,
cord-341968-uc8i9h0m	166	12	the	the	DT
cord-341968-uc8i9h0m	166	13	information	information	NN
cord-341968-uc8i9h0m	166	14	about	about	IN
cord-341968-uc8i9h0m	166	15	the	the	DT
cord-341968-uc8i9h0m	166	16	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	166	17	regulation	regulation	NN
cord-341968-uc8i9h0m	166	18	of	of	IN
cord-341968-uc8i9h0m	166	19	their	-PRON-	PRP$
cord-341968-uc8i9h0m	166	20	entry	entry	NN
cord-341968-uc8i9h0m	166	21	mechanism	mechanism	NN
cord-341968-uc8i9h0m	166	22	is	be	VBZ
cord-341968-uc8i9h0m	166	23	scarce	scarce	JJ
cord-341968-uc8i9h0m	166	24	.	.	.
cord-341968-uc8i9h0m	167	1	The	the	DT
cord-341968-uc8i9h0m	167	2	envelope	envelope	NN
cord-341968-uc8i9h0m	167	3	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	167	4	of	of	IN
cord-341968-uc8i9h0m	167	5	the	the	DT
cord-341968-uc8i9h0m	167	6	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	167	7	(	(	-LRB-
cord-341968-uc8i9h0m	167	8	EBOV	EBOV	NNP
cord-341968-uc8i9h0m	167	9	)	)	-RRB-
cord-341968-uc8i9h0m	167	10	and	and	CC
cord-341968-uc8i9h0m	167	11	Marburg	Marburg	NNP
cord-341968-uc8i9h0m	167	12	(	(	-LRB-
cord-341968-uc8i9h0m	167	13	MBGV	MBGV	NNP
cord-341968-uc8i9h0m	167	14	)	)	-RRB-
cord-341968-uc8i9h0m	167	15	viruses	virus	NNS
cord-341968-uc8i9h0m	167	16	are	be	VBP
cord-341968-uc8i9h0m	167	17	processed	process	VBN
cord-341968-uc8i9h0m	167	18	by	by	IN
cord-341968-uc8i9h0m	167	19	furin	furin	NN
cord-341968-uc8i9h0m	167	20	into	into	IN
cord-341968-uc8i9h0m	167	21	two	two	CD
cord-341968-uc8i9h0m	167	22	disulfide	disulfide	RB
cord-341968-uc8i9h0m	167	23	-	-	HYPH
cord-341968-uc8i9h0m	167	24	linked	link	VBN
cord-341968-uc8i9h0m	167	25	subunits	subunit	NNS
cord-341968-uc8i9h0m	167	26	[	[	-LRB-
cord-341968-uc8i9h0m	167	27	76	76	CD
cord-341968-uc8i9h0m	167	28	]	]	-RRB-
cord-341968-uc8i9h0m	167	29	[	[	-LRB-
cord-341968-uc8i9h0m	167	30	77	77	CD
cord-341968-uc8i9h0m	167	31	]	]	-RRB-
cord-341968-uc8i9h0m	167	32	[	[	-LRB-
cord-341968-uc8i9h0m	167	33	78	78	CD
cord-341968-uc8i9h0m	167	34	]	]	-RRB-
cord-341968-uc8i9h0m	167	35	.	.	.
cord-341968-uc8i9h0m	168	1	Except	except	IN
cord-341968-uc8i9h0m	168	2	for	for	IN
cord-341968-uc8i9h0m	168	3	the	the	DT
cord-341968-uc8i9h0m	168	4	Reston	Reston	NNP
cord-341968-uc8i9h0m	168	5	strain	strain	NN
cord-341968-uc8i9h0m	168	6	that	that	WDT
cord-341968-uc8i9h0m	168	7	has	have	VBZ
cord-341968-uc8i9h0m	168	8	no	no	DT
cord-341968-uc8i9h0m	168	9	PC	pc	NN
cord-341968-uc8i9h0m	168	10	cleavage	cleavage	NN
cord-341968-uc8i9h0m	168	11	site	site	NN
cord-341968-uc8i9h0m	168	12	motifs	motif	NNS
cord-341968-uc8i9h0m	168	13	,	,	,
cord-341968-uc8i9h0m	168	14	all	all	DT
cord-341968-uc8i9h0m	168	15	other	other	JJ
cord-341968-uc8i9h0m	168	16	EBOV	EBOV	NNP
cord-341968-uc8i9h0m	168	17	strains	strain	NNS
cord-341968-uc8i9h0m	168	18	have	have	VBP
cord-341968-uc8i9h0m	168	19	one	one	CD
cord-341968-uc8i9h0m	168	20	;	;	:
cord-341968-uc8i9h0m	168	21	the	the	DT
cord-341968-uc8i9h0m	168	22	Reston	Reston	NNP
cord-341968-uc8i9h0m	168	23	strain	strain	NN
cord-341968-uc8i9h0m	168	24	is	be	VBZ
cord-341968-uc8i9h0m	168	25	less	less	RBR
cord-341968-uc8i9h0m	168	26	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	168	27	than	than	IN
cord-341968-uc8i9h0m	168	28	the	the	DT
cord-341968-uc8i9h0m	168	29	other	other	JJ
cord-341968-uc8i9h0m	168	30	EBOV	EBOV	NNP
cord-341968-uc8i9h0m	168	31	strains	strain	NNS
cord-341968-uc8i9h0m	168	32	[	[	-LRB-
cord-341968-uc8i9h0m	168	33	76	76	CD
cord-341968-uc8i9h0m	168	34	]	]	-RRB-
cord-341968-uc8i9h0m	168	35	.	.	.
cord-341968-uc8i9h0m	169	1	The	the	DT
cord-341968-uc8i9h0m	169	2	Figure	figure	NN
cord-341968-uc8i9h0m	169	3	2	2	CD
cord-341968-uc8i9h0m	169	4	.	.	.
cord-341968-uc8i9h0m	170	1	X	x	NN
cord-341968-uc8i9h0m	170	2	-	-	NN
cord-341968-uc8i9h0m	170	3	ray	ray	NN
cord-341968-uc8i9h0m	170	4	crystal	crystal	NN
cord-341968-uc8i9h0m	170	5	structure	structure	NN
cord-341968-uc8i9h0m	170	6	of	of	IN
cord-341968-uc8i9h0m	170	7	the	the	DT
cord-341968-uc8i9h0m	170	8	HIV-1	HIV-1	NNP
cord-341968-uc8i9h0m	170	9	envelope	envelope	NN
cord-341968-uc8i9h0m	170	10	pg160	pg160	NN
cord-341968-uc8i9h0m	170	11	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	170	12	monomer	monomer	NN
cord-341968-uc8i9h0m	170	13	.	.	.
cord-341968-uc8i9h0m	171	1	The	the	DT
cord-341968-uc8i9h0m	171	2	fusion	fusion	NN
cord-341968-uc8i9h0m	171	3	machine	machine	NN
cord-341968-uc8i9h0m	171	4	is	be	VBZ
cord-341968-uc8i9h0m	171	5	composed	compose	VBN
cord-341968-uc8i9h0m	171	6	of	of	IN
cord-341968-uc8i9h0m	171	7	three	three	CD
cord-341968-uc8i9h0m	171	8	gp160	gp160	NNP
cord-341968-uc8i9h0m	171	9	monomers	monomer	NNS
cord-341968-uc8i9h0m	171	10	which	which	WDT
cord-341968-uc8i9h0m	171	11	are	be	VBP
cord-341968-uc8i9h0m	171	12	divided	divide	VBN
cord-341968-uc8i9h0m	171	13	into	into	IN
cord-341968-uc8i9h0m	171	14	N	n	CD
cord-341968-uc8i9h0m	171	15	-	-	HYPH
cord-341968-uc8i9h0m	171	16	terminal	terminal	NN
cord-341968-uc8i9h0m	171	17	gp120	gp120	CD
cord-341968-uc8i9h0m	171	18	(	(	-LRB-
cord-341968-uc8i9h0m	171	19	green	green	NNP
cord-341968-uc8i9h0m	171	20	)	)	-RRB-
cord-341968-uc8i9h0m	171	21	and	and	CC
cord-341968-uc8i9h0m	171	22	C	c	NN
cord-341968-uc8i9h0m	171	23	-	-	HYPH
cord-341968-uc8i9h0m	171	24	terminal	terminal	NN
cord-341968-uc8i9h0m	171	25	pg41	pg41	NNP
cord-341968-uc8i9h0m	171	26	(	(	-LRB-
cord-341968-uc8i9h0m	171	27	gray	gray	NNP
cord-341968-uc8i9h0m	171	28	)	)	-RRB-
cord-341968-uc8i9h0m	171	29	.	.	.
cord-341968-uc8i9h0m	172	1	Residue	residue	NN
cord-341968-uc8i9h0m	172	2	in	in	IN
cord-341968-uc8i9h0m	172	3	red	red	JJ
cord-341968-uc8i9h0m	172	4	denotes	denote	VBZ
cord-341968-uc8i9h0m	172	5	the	the	DT
cord-341968-uc8i9h0m	172	6	end	end	NN
cord-341968-uc8i9h0m	172	7	of	of	IN
cord-341968-uc8i9h0m	172	8	gp120	gp120	NN
cord-341968-uc8i9h0m	172	9	and	and	CC
cord-341968-uc8i9h0m	172	10	residue	residue	NN
cord-341968-uc8i9h0m	172	11	in	in	IN
cord-341968-uc8i9h0m	172	12	blue	blue	JJ
cord-341968-uc8i9h0m	172	13	the	the	DT
cord-341968-uc8i9h0m	172	14	beginning	beginning	NN
cord-341968-uc8i9h0m	172	15	of	of	IN
cord-341968-uc8i9h0m	172	16	gp41	gp41	NNP
cord-341968-uc8i9h0m	172	17	after	after	IN
cord-341968-uc8i9h0m	172	18	PC	pc	NN
cord-341968-uc8i9h0m	172	19	cleavage	cleavage	NN
cord-341968-uc8i9h0m	172	20	.	.	.
cord-341968-uc8i9h0m	173	1	PDB	PDB	NNP
cord-341968-uc8i9h0m	173	2	ID	ID	NNP
cord-341968-uc8i9h0m	173	3	code	code	NN
cord-341968-uc8i9h0m	173	4	6MTJ	6mtj	UH
cord-341968-uc8i9h0m	173	5	.	.	.
cord-341968-uc8i9h0m	174	1	The	the	DT
cord-341968-uc8i9h0m	174	2	duck	duck	NN
cord-341968-uc8i9h0m	174	3	hepatitis	hepatitis	NN
cord-341968-uc8i9h0m	174	4	B	b	NN
cord-341968-uc8i9h0m	174	5	virus	virus	NN
cord-341968-uc8i9h0m	174	6	(	(	-LRB-
cord-341968-uc8i9h0m	174	7	DHBV	DHBV	NNP
cord-341968-uc8i9h0m	174	8	)	)	-RRB-
cord-341968-uc8i9h0m	174	9	has	have	VBZ
cord-341968-uc8i9h0m	174	10	been	be	VBN
cord-341968-uc8i9h0m	174	11	used	use	VBN
cord-341968-uc8i9h0m	174	12	as	as	IN
cord-341968-uc8i9h0m	174	13	a	a	DT
cord-341968-uc8i9h0m	174	14	model	model	NN
cord-341968-uc8i9h0m	174	15	to	to	TO
cord-341968-uc8i9h0m	174	16	study	study	VB
cord-341968-uc8i9h0m	174	17	the	the	DT
cord-341968-uc8i9h0m	174	18	hepatitis	hepatitis	NN
cord-341968-uc8i9h0m	174	19	B	B	NNP
cord-341968-uc8i9h0m	174	20	virus	virus	NN
cord-341968-uc8i9h0m	174	21	(	(	-LRB-
cord-341968-uc8i9h0m	174	22	HBV	HBV	NNP
cord-341968-uc8i9h0m	174	23	)	)	-RRB-
cord-341968-uc8i9h0m	174	24	.	.	.
cord-341968-uc8i9h0m	175	1	The	the	DT
cord-341968-uc8i9h0m	175	2	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	175	3	events	event	NNS
cord-341968-uc8i9h0m	175	4	that	that	WDT
cord-341968-uc8i9h0m	175	5	regulate	regulate	VBP
cord-341968-uc8i9h0m	175	6	the	the	DT
cord-341968-uc8i9h0m	175	7	cell	cell	NN
cord-341968-uc8i9h0m	175	8	entry	entry	NN
cord-341968-uc8i9h0m	175	9	mechanism	mechanism	NN
cord-341968-uc8i9h0m	175	10	of	of	IN
cord-341968-uc8i9h0m	175	11	this	this	DT
cord-341968-uc8i9h0m	175	12	hepadnavirus	hepadnavirus	NN
cord-341968-uc8i9h0m	175	13	have	have	VBP
cord-341968-uc8i9h0m	175	14	not	not	RB
cord-341968-uc8i9h0m	175	15	attracted	attract	VBN
cord-341968-uc8i9h0m	175	16	much	much	JJ
cord-341968-uc8i9h0m	175	17	attention	attention	NN
cord-341968-uc8i9h0m	175	18	,	,	,
cord-341968-uc8i9h0m	175	19	but	but	CC
cord-341968-uc8i9h0m	175	20	there	there	EX
cord-341968-uc8i9h0m	175	21	is	be	VBZ
cord-341968-uc8i9h0m	175	22	evidence	evidence	NN
cord-341968-uc8i9h0m	175	23	of	of	IN
cord-341968-uc8i9h0m	175	24	the	the	DT
cord-341968-uc8i9h0m	175	25	cleavage	cleavage	NN
cord-341968-uc8i9h0m	175	26	of	of	IN
cord-341968-uc8i9h0m	175	27	the	the	DT
cord-341968-uc8i9h0m	175	28	envelope	envelope	NN
cord-341968-uc8i9h0m	175	29	proteins	protein	NNS
cord-341968-uc8i9h0m	175	30	by	by	IN
cord-341968-uc8i9h0m	175	31	PCs	pc	NNS
cord-341968-uc8i9h0m	175	32	[	[	-LRB-
cord-341968-uc8i9h0m	175	33	75	75	CD
cord-341968-uc8i9h0m	175	34	]	]	-RRB-
cord-341968-uc8i9h0m	175	35	.	.	.
cord-341968-uc8i9h0m	176	1	Single	single	JJ
cord-341968-uc8i9h0m	176	2	-	-	HYPH
cord-341968-uc8i9h0m	176	3	stranded	strand	VBN
cord-341968-uc8i9h0m	176	4	negative	negative	JJ
cord-341968-uc8i9h0m	176	5	-	-	HYPH
cord-341968-uc8i9h0m	176	6	sense	sense	NN
cord-341968-uc8i9h0m	176	7	RNA	RNA	NNP
cord-341968-uc8i9h0m	176	8	viruses	virus	NNS
cord-341968-uc8i9h0m	176	9	of	of	IN
cord-341968-uc8i9h0m	176	10	the	the	DT
cord-341968-uc8i9h0m	176	11	Filoviridae	Filoviridae	NNP
cord-341968-uc8i9h0m	176	12	and	and	CC
cord-341968-uc8i9h0m	176	13	Arenaviridae	Arenaviridae	NNP
cord-341968-uc8i9h0m	176	14	families	family	NNS
cord-341968-uc8i9h0m	176	15	and	and	CC
cord-341968-uc8i9h0m	176	16	the	the	DT
cord-341968-uc8i9h0m	176	17	new	new	JJ
cord-341968-uc8i9h0m	176	18	-	-	HYPH
cord-341968-uc8i9h0m	176	19	order	order	NN
cord-341968-uc8i9h0m	176	20	Bunyavirales	Bunyavirales	NNP
cord-341968-uc8i9h0m	176	21	are	be	VBP
cord-341968-uc8i9h0m	176	22	the	the	DT
cord-341968-uc8i9h0m	176	23	causative	causative	JJ
cord-341968-uc8i9h0m	176	24	agents	agent	NNS
cord-341968-uc8i9h0m	176	25	of	of	IN
cord-341968-uc8i9h0m	176	26	lethal	lethal	JJ
cord-341968-uc8i9h0m	176	27	hemorrhagic	hemorrhagic	JJ
cord-341968-uc8i9h0m	176	28	fever	fever	NN
cord-341968-uc8i9h0m	176	29	diseases	disease	NNS
cord-341968-uc8i9h0m	176	30	.	.	.
cord-341968-uc8i9h0m	177	1	Despite	despite	IN
cord-341968-uc8i9h0m	177	2	the	the	DT
cord-341968-uc8i9h0m	177	3	seriousness	seriousness	NN
cord-341968-uc8i9h0m	177	4	of	of	IN
cord-341968-uc8i9h0m	177	5	the	the	DT
cord-341968-uc8i9h0m	177	6	health	health	NN
cord-341968-uc8i9h0m	177	7	threat	threat	NN
cord-341968-uc8i9h0m	177	8	these	these	DT
cord-341968-uc8i9h0m	177	9	viruses	virus	NNS
cord-341968-uc8i9h0m	177	10	represent	represent	VBP
cord-341968-uc8i9h0m	177	11	,	,	,
cord-341968-uc8i9h0m	177	12	the	the	DT
cord-341968-uc8i9h0m	177	13	information	information	NN
cord-341968-uc8i9h0m	177	14	about	about	IN
cord-341968-uc8i9h0m	177	15	the	the	DT
cord-341968-uc8i9h0m	177	16	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	177	17	regulation	regulation	NN
cord-341968-uc8i9h0m	177	18	of	of	IN
cord-341968-uc8i9h0m	177	19	their	-PRON-	PRP$
cord-341968-uc8i9h0m	177	20	entry	entry	NN
cord-341968-uc8i9h0m	177	21	mechanism	mechanism	NN
cord-341968-uc8i9h0m	177	22	is	be	VBZ
cord-341968-uc8i9h0m	177	23	scarce	scarce	JJ
cord-341968-uc8i9h0m	177	24	.	.	.
cord-341968-uc8i9h0m	178	1	The	the	DT
cord-341968-uc8i9h0m	178	2	envelope	envelope	NN
cord-341968-uc8i9h0m	178	3	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	178	4	of	of	IN
cord-341968-uc8i9h0m	178	5	the	the	DT
cord-341968-uc8i9h0m	178	6	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	178	7	(	(	-LRB-
cord-341968-uc8i9h0m	178	8	EBOV	EBOV	NNP
cord-341968-uc8i9h0m	178	9	)	)	-RRB-
cord-341968-uc8i9h0m	178	10	and	and	CC
cord-341968-uc8i9h0m	178	11	Marburg	Marburg	NNP
cord-341968-uc8i9h0m	178	12	(	(	-LRB-
cord-341968-uc8i9h0m	178	13	MBGV	MBGV	NNP
cord-341968-uc8i9h0m	178	14	)	)	-RRB-
cord-341968-uc8i9h0m	178	15	viruses	virus	NNS
cord-341968-uc8i9h0m	178	16	are	be	VBP
cord-341968-uc8i9h0m	178	17	processed	process	VBN
cord-341968-uc8i9h0m	178	18	by	by	IN
cord-341968-uc8i9h0m	178	19	furin	furin	NN
cord-341968-uc8i9h0m	178	20	into	into	IN
cord-341968-uc8i9h0m	178	21	two	two	CD
cord-341968-uc8i9h0m	178	22	disulfide	disulfide	RB
cord-341968-uc8i9h0m	178	23	-	-	HYPH
cord-341968-uc8i9h0m	178	24	linked	link	VBN
cord-341968-uc8i9h0m	178	25	subunits	subunit	NNS
cord-341968-uc8i9h0m	178	26	[	[	-LRB-
cord-341968-uc8i9h0m	178	27	76	76	CD
cord-341968-uc8i9h0m	178	28	]	]	-RRB-
cord-341968-uc8i9h0m	178	29	[	[	-LRB-
cord-341968-uc8i9h0m	178	30	77	77	CD
cord-341968-uc8i9h0m	178	31	]	]	-RRB-
cord-341968-uc8i9h0m	178	32	[	[	-LRB-
cord-341968-uc8i9h0m	178	33	78	78	CD
cord-341968-uc8i9h0m	178	34	]	]	-RRB-
cord-341968-uc8i9h0m	178	35	.	.	.
cord-341968-uc8i9h0m	179	1	Except	except	IN
cord-341968-uc8i9h0m	179	2	for	for	IN
cord-341968-uc8i9h0m	179	3	the	the	DT
cord-341968-uc8i9h0m	179	4	Reston	Reston	NNP
cord-341968-uc8i9h0m	179	5	strain	strain	NN
cord-341968-uc8i9h0m	179	6	that	that	WDT
cord-341968-uc8i9h0m	179	7	has	have	VBZ
cord-341968-uc8i9h0m	179	8	no	no	DT
cord-341968-uc8i9h0m	179	9	PC	pc	NN
cord-341968-uc8i9h0m	179	10	cleavage	cleavage	NN
cord-341968-uc8i9h0m	179	11	site	site	NN
cord-341968-uc8i9h0m	179	12	motifs	motif	NNS
cord-341968-uc8i9h0m	179	13	,	,	,
cord-341968-uc8i9h0m	179	14	all	all	DT
cord-341968-uc8i9h0m	179	15	other	other	JJ
cord-341968-uc8i9h0m	179	16	EBOV	EBOV	NNP
cord-341968-uc8i9h0m	179	17	strains	strain	NNS
cord-341968-uc8i9h0m	179	18	have	have	VBP
cord-341968-uc8i9h0m	179	19	one	one	CD
cord-341968-uc8i9h0m	179	20	;	;	:
cord-341968-uc8i9h0m	179	21	the	the	DT
cord-341968-uc8i9h0m	179	22	Reston	Reston	NNP
cord-341968-uc8i9h0m	179	23	strain	strain	NN
cord-341968-uc8i9h0m	179	24	is	be	VBZ
cord-341968-uc8i9h0m	179	25	less	less	RBR
cord-341968-uc8i9h0m	179	26	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	179	27	than	than	IN
cord-341968-uc8i9h0m	179	28	the	the	DT
cord-341968-uc8i9h0m	179	29	other	other	JJ
cord-341968-uc8i9h0m	179	30	EBOV	EBOV	NNP
cord-341968-uc8i9h0m	179	31	strains	strain	NNS
cord-341968-uc8i9h0m	179	32	[	[	-LRB-
cord-341968-uc8i9h0m	179	33	76	76	CD
cord-341968-uc8i9h0m	179	34	]	]	-RRB-
cord-341968-uc8i9h0m	179	35	.	.	.
cord-341968-uc8i9h0m	180	1	The	the	DT
cord-341968-uc8i9h0m	180	2	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	180	3	of	of	IN
cord-341968-uc8i9h0m	180	4	MBGV	MBGV	NNP
cord-341968-uc8i9h0m	180	5	has	have	VBZ
cord-341968-uc8i9h0m	180	6	two	two	CD
cord-341968-uc8i9h0m	180	7	PC	pc	NN
cord-341968-uc8i9h0m	180	8	cleavage	cleavage	NN
cord-341968-uc8i9h0m	180	9	site	site	NN
cord-341968-uc8i9h0m	180	10	motifs	motif	NNS
cord-341968-uc8i9h0m	180	11	that	that	WDT
cord-341968-uc8i9h0m	180	12	do	do	VBP
cord-341968-uc8i9h0m	180	13	not	not	RB
cord-341968-uc8i9h0m	180	14	agree	agree	VB
cord-341968-uc8i9h0m	180	15	in	in	IN
cord-341968-uc8i9h0m	180	16	their	-PRON-	PRP$
cord-341968-uc8i9h0m	180	17	amino	amino	NN
cord-341968-uc8i9h0m	180	18	acid	acid	NN
cord-341968-uc8i9h0m	180	19	sequence	sequence	NN
cord-341968-uc8i9h0m	180	20	and	and	CC
cord-341968-uc8i9h0m	180	21	position	position	NN
cord-341968-uc8i9h0m	180	22	compared	compare	VBN
cord-341968-uc8i9h0m	180	23	to	to	IN
cord-341968-uc8i9h0m	180	24	the	the	DT
cord-341968-uc8i9h0m	180	25	single	single	JJ
cord-341968-uc8i9h0m	180	26	PC	pc	NN
cord-341968-uc8i9h0m	180	27	site	site	NN
cord-341968-uc8i9h0m	180	28	in	in	IN
cord-341968-uc8i9h0m	180	29	the	the	DT
cord-341968-uc8i9h0m	180	30	EBOV	EBOV	NNP
cord-341968-uc8i9h0m	180	31	protein	protein	NN
cord-341968-uc8i9h0m	180	32	[	[	-LRB-
cord-341968-uc8i9h0m	180	33	78	78	CD
cord-341968-uc8i9h0m	180	34	]	]	-RRB-
cord-341968-uc8i9h0m	180	35	.	.	.
cord-341968-uc8i9h0m	181	1	The	the	DT
cord-341968-uc8i9h0m	181	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	181	3	by	by	IN
cord-341968-uc8i9h0m	181	4	furin	furin	NN
cord-341968-uc8i9h0m	181	5	seems	seem	VBZ
cord-341968-uc8i9h0m	181	6	to	to	TO
cord-341968-uc8i9h0m	181	7	be	be	VB
cord-341968-uc8i9h0m	181	8	dispensable	dispensable	JJ
cord-341968-uc8i9h0m	181	9	because	because	IN
cord-341968-uc8i9h0m	181	10	the	the	DT
cord-341968-uc8i9h0m	181	11	elimination	elimination	NN
cord-341968-uc8i9h0m	181	12	of	of	IN
cord-341968-uc8i9h0m	181	13	the	the	DT
cord-341968-uc8i9h0m	181	14	PC	pc	NN
cord-341968-uc8i9h0m	181	15	site	site	NN
cord-341968-uc8i9h0m	181	16	in	in	IN
cord-341968-uc8i9h0m	181	17	the	the	DT
cord-341968-uc8i9h0m	181	18	EBOV	EBOV	NNP
cord-341968-uc8i9h0m	181	19	protein	protein	NN
cord-341968-uc8i9h0m	181	20	does	do	VBZ
cord-341968-uc8i9h0m	181	21	not	not	RB
cord-341968-uc8i9h0m	181	22	affect	affect	VB
cord-341968-uc8i9h0m	181	23	the	the	DT
cord-341968-uc8i9h0m	181	24	virus	virus	NN
cord-341968-uc8i9h0m	181	25	replication	replication	NN
cord-341968-uc8i9h0m	181	26	in	in	IN
cord-341968-uc8i9h0m	181	27	cultured	cultured	JJ
cord-341968-uc8i9h0m	181	28	cells	cell	NNS
cord-341968-uc8i9h0m	181	29	or	or	CC
cord-341968-uc8i9h0m	181	30	the	the	DT
cord-341968-uc8i9h0m	181	31	disease	disease	NN
cord-341968-uc8i9h0m	181	32	progression	progression	NN
cord-341968-uc8i9h0m	181	33	in	in	IN
cord-341968-uc8i9h0m	181	34	experimental	experimental	JJ
cord-341968-uc8i9h0m	181	35	animals	animal	NNS
cord-341968-uc8i9h0m	181	36	[	[	-LRB-
cord-341968-uc8i9h0m	181	37	79	79	CD
cord-341968-uc8i9h0m	181	38	]	]	-RRB-
cord-341968-uc8i9h0m	181	39	[	[	-LRB-
cord-341968-uc8i9h0m	181	40	80	80	CD
cord-341968-uc8i9h0m	181	41	]	]	-RRB-
cord-341968-uc8i9h0m	181	42	[	[	-LRB-
cord-341968-uc8i9h0m	181	43	81	81	CD
cord-341968-uc8i9h0m	181	44	]	]	-RRB-
cord-341968-uc8i9h0m	181	45	.	.	.
cord-341968-uc8i9h0m	182	1	EBOV	EBOV	NNP
cord-341968-uc8i9h0m	182	2	requires	require	VBZ
cord-341968-uc8i9h0m	182	3	further	further	JJ
cord-341968-uc8i9h0m	182	4	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	182	5	processing	processing	NN
cord-341968-uc8i9h0m	182	6	of	of	IN
cord-341968-uc8i9h0m	182	7	the	the	DT
cord-341968-uc8i9h0m	182	8	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	182	9	binding	bind	VBG
cord-341968-uc8i9h0m	182	10	domain	domain	NN
cord-341968-uc8i9h0m	182	11	by	by	IN
cord-341968-uc8i9h0m	182	12	endosomal	endosomal	NNP
cord-341968-uc8i9h0m	182	13	cathepsins	cathepsin	NNS
cord-341968-uc8i9h0m	182	14	in	in	IN
cord-341968-uc8i9h0m	182	15	order	order	NN
cord-341968-uc8i9h0m	182	16	to	to	TO
cord-341968-uc8i9h0m	182	17	gain	gain	VB
cord-341968-uc8i9h0m	182	18	binding	bind	VBG
cord-341968-uc8i9h0m	182	19	activity	activity	NN
cord-341968-uc8i9h0m	182	20	[	[	-LRB-
cord-341968-uc8i9h0m	182	21	82	82	CD
cord-341968-uc8i9h0m	182	22	]	]	-RRB-
cord-341968-uc8i9h0m	182	23	[	[	-LRB-
cord-341968-uc8i9h0m	182	24	83	83	CD
cord-341968-uc8i9h0m	182	25	]	]	-RRB-
cord-341968-uc8i9h0m	182	26	[	[	-LRB-
cord-341968-uc8i9h0m	182	27	84	84	CD
cord-341968-uc8i9h0m	182	28	]	]	-RRB-
cord-341968-uc8i9h0m	182	29	.	.	.
cord-341968-uc8i9h0m	183	1	Filoviruses	filovirus	NNS
cord-341968-uc8i9h0m	183	2	are	be	VBP
cord-341968-uc8i9h0m	183	3	different	different	JJ
cord-341968-uc8i9h0m	183	4	from	from	IN
cord-341968-uc8i9h0m	183	5	other	other	JJ
cord-341968-uc8i9h0m	183	6	viruses	virus	NNS
cord-341968-uc8i9h0m	183	7	in	in	IN
cord-341968-uc8i9h0m	183	8	that	that	IN
cord-341968-uc8i9h0m	183	9	they	-PRON-	PRP
cord-341968-uc8i9h0m	183	10	require	require	VBP
cord-341968-uc8i9h0m	183	11	additional	additional	JJ
cord-341968-uc8i9h0m	183	12	factors	factor	NNS
cord-341968-uc8i9h0m	183	13	or	or	CC
cord-341968-uc8i9h0m	183	14	modifications	modification	NNS
cord-341968-uc8i9h0m	183	15	of	of	IN
cord-341968-uc8i9h0m	183	16	the	the	DT
cord-341968-uc8i9h0m	183	17	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	183	18	in	in	IN
cord-341968-uc8i9h0m	183	19	order	order	NN
cord-341968-uc8i9h0m	183	20	to	to	TO
cord-341968-uc8i9h0m	183	21	gain	gain	VB
cord-341968-uc8i9h0m	183	22	infectivity	infectivity	NN
cord-341968-uc8i9h0m	183	23	[	[	-LRB-
cord-341968-uc8i9h0m	183	24	85	85	CD
cord-341968-uc8i9h0m	183	25	,	,	,
cord-341968-uc8i9h0m	183	26	86	86	CD
cord-341968-uc8i9h0m	183	27	]	]	-RRB-
cord-341968-uc8i9h0m	183	28	.	.	.
cord-341968-uc8i9h0m	184	1	The	the	DT
cord-341968-uc8i9h0m	184	2	Crimean	Crimean	NNP
cord-341968-uc8i9h0m	184	3	-	-	HYPH
cord-341968-uc8i9h0m	184	4	Congo	Congo	NNP
cord-341968-uc8i9h0m	184	5	hemorrhagic	hemorrhagic	JJ
cord-341968-uc8i9h0m	184	6	fever	fever	NN
cord-341968-uc8i9h0m	184	7	bunyavirus	bunyavirus	NN
cord-341968-uc8i9h0m	184	8	(	(	-LRB-
cord-341968-uc8i9h0m	184	9	CCHFV	CCHFV	NNP
cord-341968-uc8i9h0m	184	10	)	)	-RRB-
cord-341968-uc8i9h0m	184	11	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	184	12	is	be	VBZ
cord-341968-uc8i9h0m	184	13	processed	process	VBN
cord-341968-uc8i9h0m	184	14	by	by	IN
cord-341968-uc8i9h0m	184	15	furin	furin	NN
cord-341968-uc8i9h0m	184	16	and	and	CC
cord-341968-uc8i9h0m	184	17	the	the	DT
cord-341968-uc8i9h0m	184	18	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	184	19	convertase	convertase	NNP
cord-341968-uc8i9h0m	184	20	SKI-1	SKI-1	NNP
cord-341968-uc8i9h0m	184	21	,	,	,
cord-341968-uc8i9h0m	184	22	a	a	DT
cord-341968-uc8i9h0m	184	23	PC	pc	NN
cord-341968-uc8i9h0m	184	24	of	of	IN
cord-341968-uc8i9h0m	184	25	the	the	DT
cord-341968-uc8i9h0m	184	26	pyrolysin	pyrolysin	JJ
cord-341968-uc8i9h0m	184	27	-	-	HYPH
cord-341968-uc8i9h0m	184	28	like	like	JJ
cord-341968-uc8i9h0m	184	29	type	type	NN
cord-341968-uc8i9h0m	184	30	and	and	CC
cord-341968-uc8i9h0m	184	31	also	also	RB
cord-341968-uc8i9h0m	184	32	known	know	VBN
cord-341968-uc8i9h0m	184	33	as	as	IN
cord-341968-uc8i9h0m	184	34	S1P	s1p	CD
cord-341968-uc8i9h0m	184	35	,	,	,
cord-341968-uc8i9h0m	184	36	which	which	WDT
cord-341968-uc8i9h0m	184	37	has	have	VBZ
cord-341968-uc8i9h0m	184	38	a	a	DT
cord-341968-uc8i9h0m	184	39	cleavage	cleavage	NN
cord-341968-uc8i9h0m	184	40	site	site	NN
cord-341968-uc8i9h0m	184	41	specificity	specificity	NN
cord-341968-uc8i9h0m	184	42	different	different	JJ
cord-341968-uc8i9h0m	184	43	from	from	IN
cord-341968-uc8i9h0m	184	44	the	the	DT
cord-341968-uc8i9h0m	184	45	polybasic	polybasic	JJ
cord-341968-uc8i9h0m	184	46	specificity	specificity	NN
cord-341968-uc8i9h0m	184	47	of	of	IN
cord-341968-uc8i9h0m	184	48	the	the	DT
cord-341968-uc8i9h0m	184	49	Kexin	Kexin	NNP
cord-341968-uc8i9h0m	184	50	-	-	HYPH
cord-341968-uc8i9h0m	184	51	like	like	JJ
cord-341968-uc8i9h0m	184	52	PCs	pc	NNS
cord-341968-uc8i9h0m	184	53	[	[	-LRB-
cord-341968-uc8i9h0m	184	54	87	87	CD
cord-341968-uc8i9h0m	184	55	,	,	,
cord-341968-uc8i9h0m	184	56	88	88	CD
cord-341968-uc8i9h0m	184	57	]	]	-RRB-
cord-341968-uc8i9h0m	184	58	.	.	.
cord-341968-uc8i9h0m	185	1	The	the	DT
cord-341968-uc8i9h0m	185	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	185	3	by	by	IN
cord-341968-uc8i9h0m	185	4	furin	furin	NN
cord-341968-uc8i9h0m	185	5	is	be	VBZ
cord-341968-uc8i9h0m	185	6	not	not	RB
cord-341968-uc8i9h0m	185	7	essential	essential	JJ
cord-341968-uc8i9h0m	185	8	,	,	,
cord-341968-uc8i9h0m	185	9	but	but	CC
cord-341968-uc8i9h0m	185	10	inactivating	inactivate	VBG
cord-341968-uc8i9h0m	185	11	the	the	DT
cord-341968-uc8i9h0m	185	12	cleavage	cleavage	NN
cord-341968-uc8i9h0m	185	13	site	site	NN
cord-341968-uc8i9h0m	185	14	slows	slow	VBZ
cord-341968-uc8i9h0m	185	15	down	down	RP
cord-341968-uc8i9h0m	185	16	virus	virus	NN
cord-341968-uc8i9h0m	185	17	replication	replication	NN
cord-341968-uc8i9h0m	185	18	[	[	-LRB-
cord-341968-uc8i9h0m	185	19	89	89	CD
cord-341968-uc8i9h0m	185	20	,	,	,
cord-341968-uc8i9h0m	185	21	90	90	CD
cord-341968-uc8i9h0m	185	22	]	]	-RRB-
cord-341968-uc8i9h0m	185	23	.	.	.
cord-341968-uc8i9h0m	186	1	The	the	DT
cord-341968-uc8i9h0m	186	2	lymphocytic	lymphocytic	JJ
cord-341968-uc8i9h0m	186	3	choriomeningitis	choriomeningitis	NN
cord-341968-uc8i9h0m	186	4	(	(	-LRB-
cord-341968-uc8i9h0m	186	5	LCMV	LCMV	NNP
cord-341968-uc8i9h0m	186	6	)	)	-RRB-
cord-341968-uc8i9h0m	186	7	and	and	CC
cord-341968-uc8i9h0m	186	8	the	the	DT
cord-341968-uc8i9h0m	186	9	Lassa	Lassa	NNP
cord-341968-uc8i9h0m	186	10	(	(	-LRB-
cord-341968-uc8i9h0m	186	11	LASV	LASV	NNP
cord-341968-uc8i9h0m	186	12	)	)	-RRB-
cord-341968-uc8i9h0m	186	13	arenaviruses	arenaviruses	NNP
cord-341968-uc8i9h0m	186	14	are	be	VBP
cord-341968-uc8i9h0m	186	15	known	know	VBN
cord-341968-uc8i9h0m	186	16	to	to	TO
cord-341968-uc8i9h0m	186	17	also	also	RB
cord-341968-uc8i9h0m	186	18	require	require	VB
cord-341968-uc8i9h0m	186	19	SKI-1	SKI-1	NNP
cord-341968-uc8i9h0m	186	20	activity	activity	NN
cord-341968-uc8i9h0m	186	21	for	for	IN
cord-341968-uc8i9h0m	186	22	the	the	DT
cord-341968-uc8i9h0m	186	23	cleavage	cleavage	NN
cord-341968-uc8i9h0m	186	24	of	of	IN
cord-341968-uc8i9h0m	186	25	their	-PRON-	PRP$
cord-341968-uc8i9h0m	186	26	envelope	envelope	NN
cord-341968-uc8i9h0m	186	27	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	186	28	[	[	-LRB-
cord-341968-uc8i9h0m	186	29	89	89	CD
cord-341968-uc8i9h0m	186	30	,	,	,
cord-341968-uc8i9h0m	186	31	90	90	CD
cord-341968-uc8i9h0m	186	32	]	]	-RRB-
cord-341968-uc8i9h0m	186	33	.	.	.
cord-341968-uc8i9h0m	187	1	The	the	DT
cord-341968-uc8i9h0m	187	2	Paramyxoviridae	Paramyxoviridae	NNP
cord-341968-uc8i9h0m	187	3	is	be	VBZ
cord-341968-uc8i9h0m	187	4	a	a	DT
cord-341968-uc8i9h0m	187	5	diverse	diverse	JJ
cord-341968-uc8i9h0m	187	6	family	family	NN
cord-341968-uc8i9h0m	187	7	of	of	IN
cord-341968-uc8i9h0m	187	8	viruses	virus	NNS
cord-341968-uc8i9h0m	187	9	,	,	,
cord-341968-uc8i9h0m	187	10	and	and	CC
cord-341968-uc8i9h0m	187	11	a	a	DT
cord-341968-uc8i9h0m	187	12	variety	variety	NN
cord-341968-uc8i9h0m	187	13	of	of	IN
cord-341968-uc8i9h0m	187	14	proteases	protease	NNS
cord-341968-uc8i9h0m	187	15	activate	activate	VBP
cord-341968-uc8i9h0m	187	16	their	-PRON-	PRP$
cord-341968-uc8i9h0m	187	17	fusion	fusion	NN
cord-341968-uc8i9h0m	187	18	proteins	protein	NNS
cord-341968-uc8i9h0m	187	19	.	.	.
cord-341968-uc8i9h0m	188	1	Some	some	DT
cord-341968-uc8i9h0m	188	2	paramyxoviruses	paramyxovirus	NNS
cord-341968-uc8i9h0m	188	3	are	be	VBP
cord-341968-uc8i9h0m	188	4	highly	highly	RB
cord-341968-uc8i9h0m	188	5	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	188	6	.	.	.
cord-341968-uc8i9h0m	189	1	Single	single	JJ
cord-341968-uc8i9h0m	189	2	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	189	3	processing	processing	NN
cord-341968-uc8i9h0m	189	4	of	of	IN
cord-341968-uc8i9h0m	189	5	the	the	DT
cord-341968-uc8i9h0m	189	6	fusion	fusion	NN
cord-341968-uc8i9h0m	189	7	protein	protein	NN
cord-341968-uc8i9h0m	189	8	occurs	occur	VBZ
cord-341968-uc8i9h0m	189	9	for	for	IN
cord-341968-uc8i9h0m	189	10	most	most	JJS
cord-341968-uc8i9h0m	189	11	of	of	IN
cord-341968-uc8i9h0m	189	12	these	these	DT
cord-341968-uc8i9h0m	189	13	viruses	virus	NNS
cord-341968-uc8i9h0m	189	14	.	.	.
cord-341968-uc8i9h0m	190	1	PCs	pc	NNS
cord-341968-uc8i9h0m	190	2	perform	perform	VBP
cord-341968-uc8i9h0m	190	3	the	the	DT
cord-341968-uc8i9h0m	190	4	cleavage	cleavage	NN
cord-341968-uc8i9h0m	190	5	in	in	IN
cord-341968-uc8i9h0m	190	6	the	the	DT
cord-341968-uc8i9h0m	190	7	parainfluenza	parainfluenza	NN
cord-341968-uc8i9h0m	190	8	and	and	CC
cord-341968-uc8i9h0m	190	9	the	the	DT
cord-341968-uc8i9h0m	190	10	measles	measle	NNS
cord-341968-uc8i9h0m	190	11	(	(	-LRB-
cord-341968-uc8i9h0m	190	12	MV	MV	NNP
cord-341968-uc8i9h0m	190	13	)	)	-RRB-
cord-341968-uc8i9h0m	190	14	viruses	virus	NNS
cord-341968-uc8i9h0m	190	15	[	[	-LRB-
cord-341968-uc8i9h0m	190	16	91	91	CD
cord-341968-uc8i9h0m	190	17	]	]	-RRB-
cord-341968-uc8i9h0m	190	18	[	[	-LRB-
cord-341968-uc8i9h0m	190	19	92	92	CD
cord-341968-uc8i9h0m	190	20	]	]	-RRB-
cord-341968-uc8i9h0m	190	21	[	[	-LRB-
cord-341968-uc8i9h0m	190	22	93	93	CD
cord-341968-uc8i9h0m	190	23	]	]	-RRB-
cord-341968-uc8i9h0m	190	24	.	.	.
cord-341968-uc8i9h0m	191	1	There	there	EX
cord-341968-uc8i9h0m	191	2	are	be	VBP
cord-341968-uc8i9h0m	191	3	several	several	JJ
cord-341968-uc8i9h0m	191	4	serotypes	serotype	NNS
cord-341968-uc8i9h0m	191	5	of	of	IN
cord-341968-uc8i9h0m	191	6	the	the	DT
cord-341968-uc8i9h0m	191	7	avian	avian	JJ
cord-341968-uc8i9h0m	191	8	paramyxoviruses	paramyxovirus	NNS
cord-341968-uc8i9h0m	191	9	(	(	-LRB-
cord-341968-uc8i9h0m	191	10	APMV	APMV	NNP
cord-341968-uc8i9h0m	191	11	)	)	-RRB-
cord-341968-uc8i9h0m	191	12	.	.	.
cord-341968-uc8i9h0m	192	1	The	the	DT
cord-341968-uc8i9h0m	192	2	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	192	3	of	of	IN
cord-341968-uc8i9h0m	192	4	the	the	DT
cord-341968-uc8i9h0m	192	5	highly	highly	RB
cord-341968-uc8i9h0m	192	6	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	192	7	APMV-1	APMV-1	NNS
cord-341968-uc8i9h0m	192	8	,	,	,
cord-341968-uc8i9h0m	192	9	or	or	CC
cord-341968-uc8i9h0m	192	10	Newcastle	Newcastle	NNP
cord-341968-uc8i9h0m	192	11	disease	disease	NN
cord-341968-uc8i9h0m	192	12	virus	virus	NN
cord-341968-uc8i9h0m	192	13	(	(	-LRB-
cord-341968-uc8i9h0m	192	14	NDV	NDV	NNP
cord-341968-uc8i9h0m	192	15	)	)	-RRB-
cord-341968-uc8i9h0m	192	16	,	,	,
cord-341968-uc8i9h0m	192	17	is	be	VBZ
cord-341968-uc8i9h0m	192	18	cleaved	cleave	VBN
cord-341968-uc8i9h0m	192	19	by	by	IN
cord-341968-uc8i9h0m	192	20	furin	furin	NN
cord-341968-uc8i9h0m	192	21	,	,	,
cord-341968-uc8i9h0m	192	22	and	and	CC
cord-341968-uc8i9h0m	192	23	the	the	DT
cord-341968-uc8i9h0m	192	24	proteins	protein	NNS
cord-341968-uc8i9h0m	192	25	of	of	IN
cord-341968-uc8i9h0m	192	26	other	other	JJ
cord-341968-uc8i9h0m	192	27	serotypes	serotype	NNS
cord-341968-uc8i9h0m	192	28	are	be	VBP
cord-341968-uc8i9h0m	192	29	cleaved	cleave	VBN
cord-341968-uc8i9h0m	192	30	by	by	IN
cord-341968-uc8i9h0m	192	31	undetermined	undetermined	JJ
cord-341968-uc8i9h0m	192	32	trypsin	trypsin	NN
cord-341968-uc8i9h0m	192	33	-	-	HYPH
cord-341968-uc8i9h0m	192	34	like	like	JJ
cord-341968-uc8i9h0m	192	35	proteases	protease	NNS
cord-341968-uc8i9h0m	192	36	[	[	-LRB-
cord-341968-uc8i9h0m	192	37	94	94	CD
cord-341968-uc8i9h0m	192	38	,	,	,
cord-341968-uc8i9h0m	192	39	95	95	CD
cord-341968-uc8i9h0m	192	40	]	]	-RRB-
cord-341968-uc8i9h0m	192	41	.	.	.
cord-341968-uc8i9h0m	193	1	The	the	DT
cord-341968-uc8i9h0m	193	2	mutation	mutation	NN
cord-341968-uc8i9h0m	193	3	of	of	IN
cord-341968-uc8i9h0m	193	4	the	the	DT
cord-341968-uc8i9h0m	193	5	trypsin	trypsin	NN
cord-341968-uc8i9h0m	193	6	-	-	HYPH
cord-341968-uc8i9h0m	193	7	like	like	JJ
cord-341968-uc8i9h0m	193	8	sites	site	NNS
cord-341968-uc8i9h0m	193	9	into	into	IN
cord-341968-uc8i9h0m	193	10	PC	pc	NN
cord-341968-uc8i9h0m	193	11	site	site	NN
cord-341968-uc8i9h0m	193	12	motifs	motif	NNS
cord-341968-uc8i9h0m	193	13	made	make	VBD
cord-341968-uc8i9h0m	193	14	the	the	DT
cord-341968-uc8i9h0m	193	15	viruses	virus	NNS
cord-341968-uc8i9h0m	193	16	replicate	replicate	VB
cord-341968-uc8i9h0m	193	17	faster	fast	RBR
cord-341968-uc8i9h0m	193	18	in	in	IN
cord-341968-uc8i9h0m	193	19	cell	cell	NN
cord-341968-uc8i9h0m	193	20	culture	culture	NN
cord-341968-uc8i9h0m	193	21	,	,	,
cord-341968-uc8i9h0m	193	22	but	but	CC
cord-341968-uc8i9h0m	193	23	they	-PRON-	PRP
cord-341968-uc8i9h0m	193	24	remained	remain	VBD
cord-341968-uc8i9h0m	193	25	non	non	JJ
cord-341968-uc8i9h0m	193	26	-	-	JJ
cord-341968-uc8i9h0m	193	27	virulent	virulent	JJ
cord-341968-uc8i9h0m	193	28	in	in	IN
cord-341968-uc8i9h0m	193	29	vivo	vivo	NN
cord-341968-uc8i9h0m	193	30	[	[	-LRB-
cord-341968-uc8i9h0m	193	31	96	96	CD
cord-341968-uc8i9h0m	193	32	]	]	-RRB-
cord-341968-uc8i9h0m	193	33	[	[	-LRB-
cord-341968-uc8i9h0m	193	34	97	97	CD
cord-341968-uc8i9h0m	193	35	]	]	-RRB-
cord-341968-uc8i9h0m	193	36	[	[	-LRB-
cord-341968-uc8i9h0m	193	37	98	98	CD
cord-341968-uc8i9h0m	193	38	]	]	-RRB-
cord-341968-uc8i9h0m	193	39	.	.	.
cord-341968-uc8i9h0m	194	1	Conversely	conversely	RB
cord-341968-uc8i9h0m	194	2	,	,	,
cord-341968-uc8i9h0m	194	3	the	the	DT
cord-341968-uc8i9h0m	194	4	transformation	transformation	NN
cord-341968-uc8i9h0m	194	5	of	of	IN
cord-341968-uc8i9h0m	194	6	the	the	DT
cord-341968-uc8i9h0m	194	7	PC	pc	NN
cord-341968-uc8i9h0m	194	8	cleavage	cleavage	NN
cord-341968-uc8i9h0m	194	9	site	site	NN
cord-341968-uc8i9h0m	194	10	of	of	IN
cord-341968-uc8i9h0m	194	11	the	the	DT
cord-341968-uc8i9h0m	194	12	virulent	virulent	JJ
cord-341968-uc8i9h0m	194	13	APMV-1	APMV-1	NNS
cord-341968-uc8i9h0m	194	14	strain	strain	NN
cord-341968-uc8i9h0m	194	15	into	into	IN
cord-341968-uc8i9h0m	194	16	a	a	DT
cord-341968-uc8i9h0m	194	17	trypsin	trypsin	NN
cord-341968-uc8i9h0m	194	18	-	-	HYPH
cord-341968-uc8i9h0m	194	19	like	like	JJ
cord-341968-uc8i9h0m	194	20	site	site	NN
cord-341968-uc8i9h0m	195	1	induced	induce	VBN
cord-341968-uc8i9h0m	195	2	the	the	DT
cord-341968-uc8i9h0m	195	3	virus	virus	NN
cord-341968-uc8i9h0m	195	4	to	to	TO
cord-341968-uc8i9h0m	195	5	become	become	VB
cord-341968-uc8i9h0m	195	6	highly	highly	RB
cord-341968-uc8i9h0m	195	7	attenuated	attenuated	JJ
cord-341968-uc8i9h0m	195	8	[	[	-LRB-
cord-341968-uc8i9h0m	195	9	99	99	CD
cord-341968-uc8i9h0m	195	10	]	]	-RRB-
cord-341968-uc8i9h0m	195	11	.	.	.
cord-341968-uc8i9h0m	196	1	The	the	DT
cord-341968-uc8i9h0m	196	2	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	196	3	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	196	4	syncytial	syncytial	JJ
cord-341968-uc8i9h0m	196	5	virus	virus	NN
cord-341968-uc8i9h0m	196	6	(	(	-LRB-
cord-341968-uc8i9h0m	196	7	RSV	RSV	NNP
cord-341968-uc8i9h0m	196	8	)	)	-RRB-
cord-341968-uc8i9h0m	196	9	is	be	VBZ
cord-341968-uc8i9h0m	196	10	unique	unique	JJ
cord-341968-uc8i9h0m	196	11	among	among	IN
cord-341968-uc8i9h0m	196	12	paramyxoviruses	paramyxovirus	NNS
cord-341968-uc8i9h0m	196	13	in	in	IN
cord-341968-uc8i9h0m	196	14	that	that	IN
cord-341968-uc8i9h0m	196	15	its	-PRON-	PRP$
cord-341968-uc8i9h0m	196	16	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	196	17	is	be	VBZ
cord-341968-uc8i9h0m	196	18	cleaved	cleave	VBN
cord-341968-uc8i9h0m	196	19	at	at	IN
cord-341968-uc8i9h0m	196	20	two	two	CD
cord-341968-uc8i9h0m	196	21	sites	site	NNS
cord-341968-uc8i9h0m	196	22	by	by	IN
cord-341968-uc8i9h0m	196	23	PCs	pc	NNS
cord-341968-uc8i9h0m	196	24	[	[	-LRB-
cord-341968-uc8i9h0m	196	25	100	100	CD
cord-341968-uc8i9h0m	196	26	]	]	-RRB-
cord-341968-uc8i9h0m	196	27	.	.	.
cord-341968-uc8i9h0m	197	1	The	the	DT
cord-341968-uc8i9h0m	197	2	first	first	JJ
cord-341968-uc8i9h0m	197	3	cleavage	cleavage	NN
cord-341968-uc8i9h0m	197	4	takes	take	VBZ
cord-341968-uc8i9h0m	197	5	place	place	NN
cord-341968-uc8i9h0m	197	6	before	before	IN
cord-341968-uc8i9h0m	197	7	the	the	DT
cord-341968-uc8i9h0m	197	8	virus	virus	NN
cord-341968-uc8i9h0m	197	9	enters	enter	VBZ
cord-341968-uc8i9h0m	197	10	the	the	DT
cord-341968-uc8i9h0m	197	11	target	target	NN
cord-341968-uc8i9h0m	197	12	cells	cell	NNS
cord-341968-uc8i9h0m	197	13	,	,	,
cord-341968-uc8i9h0m	197	14	and	and	CC
cord-341968-uc8i9h0m	197	15	the	the	DT
cord-341968-uc8i9h0m	197	16	second	second	JJ
cord-341968-uc8i9h0m	197	17	occurs	occur	VBZ
cord-341968-uc8i9h0m	197	18	after	after	IN
cord-341968-uc8i9h0m	197	19	entry	entry	NN
cord-341968-uc8i9h0m	197	20	into	into	IN
cord-341968-uc8i9h0m	197	21	the	the	DT
cord-341968-uc8i9h0m	197	22	endosomes	endosome	NNS
cord-341968-uc8i9h0m	197	23	[	[	-LRB-
cord-341968-uc8i9h0m	197	24	101	101	CD
cord-341968-uc8i9h0m	197	25	]	]	-RRB-
cord-341968-uc8i9h0m	197	26	.	.	.
cord-341968-uc8i9h0m	198	1	Furin	furin	NN
cord-341968-uc8i9h0m	198	2	does	do	VBZ
cord-341968-uc8i9h0m	198	3	not	not	RB
cord-341968-uc8i9h0m	198	4	activate	activate	VB
cord-341968-uc8i9h0m	198	5	the	the	DT
cord-341968-uc8i9h0m	198	6	lethal	lethal	JJ
cord-341968-uc8i9h0m	198	7	Nipah	Nipah	NNP
cord-341968-uc8i9h0m	198	8	(	(	-LRB-
cord-341968-uc8i9h0m	198	9	NiV	NiV	NNP
cord-341968-uc8i9h0m	198	10	)	)	-RRB-
cord-341968-uc8i9h0m	198	11	and	and	CC
cord-341968-uc8i9h0m	198	12	Hendra	Hendra	NNP
cord-341968-uc8i9h0m	198	13	(	(	-LRB-
cord-341968-uc8i9h0m	198	14	HeV	hev	NN
cord-341968-uc8i9h0m	198	15	)	)	-RRB-
cord-341968-uc8i9h0m	198	16	viruses	virus	NNS
cord-341968-uc8i9h0m	198	17	for	for	IN
cord-341968-uc8i9h0m	198	18	entry	entry	NN
cord-341968-uc8i9h0m	198	19	;	;	:
cord-341968-uc8i9h0m	198	20	instead	instead	RB
cord-341968-uc8i9h0m	198	21	,	,	,
cord-341968-uc8i9h0m	198	22	the	the	DT
cord-341968-uc8i9h0m	198	23	viruses	virus	NNS
cord-341968-uc8i9h0m	198	24	depend	depend	VBP
cord-341968-uc8i9h0m	198	25	on	on	IN
cord-341968-uc8i9h0m	198	26	endosomal	endosomal	NNP
cord-341968-uc8i9h0m	198	27	cathepsins	cathepsins	NNP
cord-341968-uc8i9h0m	198	28	[	[	-LRB-
cord-341968-uc8i9h0m	198	29	102	102	CD
cord-341968-uc8i9h0m	198	30	,	,	,
cord-341968-uc8i9h0m	198	31	103	103	CD
cord-341968-uc8i9h0m	198	32	]	]	-RRB-
cord-341968-uc8i9h0m	198	33	.	.	.
cord-341968-uc8i9h0m	199	1	These	these	DT
cord-341968-uc8i9h0m	199	2	viruses	virus	NNS
cord-341968-uc8i9h0m	199	3	produce	produce	VBP
cord-341968-uc8i9h0m	199	4	systemic	systemic	JJ
cord-341968-uc8i9h0m	199	5	infections	infection	NNS
cord-341968-uc8i9h0m	199	6	in	in	IN
cord-341968-uc8i9h0m	199	7	several	several	JJ
cord-341968-uc8i9h0m	199	8	different	different	JJ
cord-341968-uc8i9h0m	199	9	hosts	host	NNS
cord-341968-uc8i9h0m	199	10	.	.	.
cord-341968-uc8i9h0m	200	1	The	the	DT
cord-341968-uc8i9h0m	200	2	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	200	3	of	of	IN
cord-341968-uc8i9h0m	200	4	the	the	DT
cord-341968-uc8i9h0m	200	5	Sendai	Sendai	NNP
cord-341968-uc8i9h0m	200	6	virus	virus	NN
cord-341968-uc8i9h0m	200	7	(	(	-LRB-
cord-341968-uc8i9h0m	200	8	SeV	sev	NN
cord-341968-uc8i9h0m	200	9	)	)	-RRB-
cord-341968-uc8i9h0m	200	10	requires	require	VBZ
cord-341968-uc8i9h0m	200	11	the	the	DT
cord-341968-uc8i9h0m	200	12	participation	participation	NN
cord-341968-uc8i9h0m	200	13	of	of	IN
cord-341968-uc8i9h0m	200	14	the	the	DT
cord-341968-uc8i9h0m	200	15	homologous	homologous	JJ
cord-341968-uc8i9h0m	200	16	attachment	attachment	NN
cord-341968-uc8i9h0m	200	17	protein	protein	NN
cord-341968-uc8i9h0m	200	18	hemagglutinin	hemagglutinin	NN
cord-341968-uc8i9h0m	200	19	-	-	,
cord-341968-uc8i9h0m	200	20	neuraminidase	neuraminidase	FW
cord-341968-uc8i9h0m	200	21	(	(	-LRB-
cord-341968-uc8i9h0m	200	22	HN	HN	NNP
cord-341968-uc8i9h0m	200	23	)	)	-RRB-
cord-341968-uc8i9h0m	200	24	,	,	,
cord-341968-uc8i9h0m	200	25	which	which	WDT
cord-341968-uc8i9h0m	200	26	binds	bind	VBZ
cord-341968-uc8i9h0m	200	27	the	the	DT
cord-341968-uc8i9h0m	200	28	cell	cell	NN
cord-341968-uc8i9h0m	200	29	surface	surface	NN
cord-341968-uc8i9h0m	200	30	sialic	sialic	NN
cord-341968-uc8i9h0m	200	31	acid	acid	NN
cord-341968-uc8i9h0m	200	32	receptors	receptor	NNS
cord-341968-uc8i9h0m	200	33	.	.	.
cord-341968-uc8i9h0m	201	1	SeV	SeV	NNP
cord-341968-uc8i9h0m	201	2	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	201	3	has	have	VBZ
cord-341968-uc8i9h0m	201	4	only	only	RB
cord-341968-uc8i9h0m	201	5	one	one	CD
cord-341968-uc8i9h0m	201	6	trypsin	trypsin	NN
cord-341968-uc8i9h0m	201	7	-	-	HYPH
cord-341968-uc8i9h0m	201	8	like	like	JJ
cord-341968-uc8i9h0m	201	9	site	site	NN
cord-341968-uc8i9h0m	201	10	,	,	,
cord-341968-uc8i9h0m	201	11	but	but	CC
cord-341968-uc8i9h0m	201	12	by	by	IN
cord-341968-uc8i9h0m	201	13	replacing	replace	VBG
cord-341968-uc8i9h0m	201	14	it	-PRON-	PRP
cord-341968-uc8i9h0m	201	15	with	with	IN
cord-341968-uc8i9h0m	201	16	the	the	DT
cord-341968-uc8i9h0m	201	17	two	two	CD
cord-341968-uc8i9h0m	201	18	RSV	RSV	NNP
cord-341968-uc8i9h0m	201	19	PC	pc	NN
cord-341968-uc8i9h0m	201	20	sites	site	NNS
cord-341968-uc8i9h0m	201	21	,	,	,
cord-341968-uc8i9h0m	201	22	the	the	DT
cord-341968-uc8i9h0m	201	23	dependency	dependency	NN
cord-341968-uc8i9h0m	201	24	on	on	IN
cord-341968-uc8i9h0m	201	25	HN	HN	NNP
cord-341968-uc8i9h0m	201	26	for	for	IN
cord-341968-uc8i9h0m	201	27	infection	infection	NN
cord-341968-uc8i9h0m	201	28	is	be	VBZ
cord-341968-uc8i9h0m	201	29	reduced	reduce	VBN
cord-341968-uc8i9h0m	201	30	[	[	-LRB-
cord-341968-uc8i9h0m	201	31	104	104	CD
cord-341968-uc8i9h0m	201	32	]	]	-RRB-
cord-341968-uc8i9h0m	201	33	.	.	.
cord-341968-uc8i9h0m	202	1	The	the	DT
cord-341968-uc8i9h0m	202	2	influenza	influenza	NN
cord-341968-uc8i9h0m	202	3	viruses	virus	NNS
cord-341968-uc8i9h0m	202	4	cause	cause	VBP
cord-341968-uc8i9h0m	202	5	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	202	6	disease	disease	NN
cord-341968-uc8i9h0m	202	7	and	and	CC
cord-341968-uc8i9h0m	202	8	occasional	occasional	JJ
cord-341968-uc8i9h0m	202	9	pandemics	pandemic	NNS
cord-341968-uc8i9h0m	202	10	.	.	.
cord-341968-uc8i9h0m	203	1	The	the	DT
cord-341968-uc8i9h0m	203	2	virus	virus	NN
cord-341968-uc8i9h0m	203	3	envelope	envelope	NN
cord-341968-uc8i9h0m	203	4	contains	contain	VBZ
cord-341968-uc8i9h0m	203	5	two	two	CD
cord-341968-uc8i9h0m	203	6	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	203	7	,	,	,
cord-341968-uc8i9h0m	203	8	hemagglutinin	hemagglutinin	NN
cord-341968-uc8i9h0m	203	9	(	(	-LRB-
cord-341968-uc8i9h0m	203	10	HA	HA	NNP
cord-341968-uc8i9h0m	203	11	)	)	-RRB-
cord-341968-uc8i9h0m	203	12	and	and	CC
cord-341968-uc8i9h0m	203	13	neuraminidase	neuraminidase	NN
cord-341968-uc8i9h0m	203	14	(	(	-LRB-
cord-341968-uc8i9h0m	203	15	NA	NA	NNP
cord-341968-uc8i9h0m	203	16	)	)	-RRB-
cord-341968-uc8i9h0m	203	17	.	.	.
cord-341968-uc8i9h0m	204	1	Both	both	DT
cord-341968-uc8i9h0m	204	2	proteins	protein	NNS
cord-341968-uc8i9h0m	204	3	contribute	contribute	VBP
cord-341968-uc8i9h0m	204	4	to	to	IN
cord-341968-uc8i9h0m	204	5	the	the	DT
cord-341968-uc8i9h0m	204	6	virus	virus	NN
cord-341968-uc8i9h0m	204	7	pathogenicity	pathogenicity	NN
cord-341968-uc8i9h0m	204	8	and	and	CC
cord-341968-uc8i9h0m	204	9	the	the	DT
cord-341968-uc8i9h0m	204	10	cleavage	cleavage	NN
cord-341968-uc8i9h0m	204	11	of	of	IN
cord-341968-uc8i9h0m	204	12	HA	HA	NNP
cord-341968-uc8i9h0m	204	13	0	0	CD
cord-341968-uc8i9h0m	204	14	precursor	precursor	NN
cord-341968-uc8i9h0m	204	15	into	into	IN
cord-341968-uc8i9h0m	204	16	HA	HA	NNP
cord-341968-uc8i9h0m	204	17	1	1	CD
cord-341968-uc8i9h0m	204	18	and	and	CC
cord-341968-uc8i9h0m	204	19	HA	HA	NNP
cord-341968-uc8i9h0m	204	20	2	2	CD
cord-341968-uc8i9h0m	204	21	by	by	IN
cord-341968-uc8i9h0m	204	22	the	the	DT
cord-341968-uc8i9h0m	204	23	host	host	NN
cord-341968-uc8i9h0m	204	24	cell	cell	NN
cord-341968-uc8i9h0m	204	25	PCs	pc	NNS
cord-341968-uc8i9h0m	205	1	is	be	VBZ
cord-341968-uc8i9h0m	205	2	a	a	DT
cord-341968-uc8i9h0m	205	3	significant	significant	JJ
cord-341968-uc8i9h0m	205	4	contributor	contributor	NN
cord-341968-uc8i9h0m	205	5	of	of	IN
cord-341968-uc8i9h0m	205	6	virulence	virulence	NN
cord-341968-uc8i9h0m	205	7	for	for	IN
cord-341968-uc8i9h0m	205	8	avian	avian	JJ
cord-341968-uc8i9h0m	205	9	influenza	influenza	NN
cord-341968-uc8i9h0m	205	10	(	(	-LRB-
cord-341968-uc8i9h0m	205	11	Figure	figure	NN
cord-341968-uc8i9h0m	205	12	3	3	CD
cord-341968-uc8i9h0m	205	13	)	)	-RRB-
cord-341968-uc8i9h0m	205	14	.	.	.
cord-341968-uc8i9h0m	206	1	The	the	DT
cord-341968-uc8i9h0m	206	2	extent	extent	NN
cord-341968-uc8i9h0m	206	3	and	and	CC
cord-341968-uc8i9h0m	206	4	diversity	diversity	NN
cord-341968-uc8i9h0m	206	5	of	of	IN
cord-341968-uc8i9h0m	206	6	the	the	DT
cord-341968-uc8i9h0m	206	7	cellular	cellular	JJ
cord-341968-uc8i9h0m	206	8	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	206	9	activity	activity	NN
cord-341968-uc8i9h0m	206	10	is	be	VBZ
cord-341968-uc8i9h0m	206	11	also	also	RB
cord-341968-uc8i9h0m	206	12	an	an	DT
cord-341968-uc8i9h0m	206	13	essential	essential	JJ
cord-341968-uc8i9h0m	206	14	factor	factor	NN
cord-341968-uc8i9h0m	206	15	determining	determine	VBG
cord-341968-uc8i9h0m	206	16	pathogenicity	pathogenicity	NN
cord-341968-uc8i9h0m	206	17	,	,	,
cord-341968-uc8i9h0m	206	18	spread	spread	VBN
cord-341968-uc8i9h0m	206	19	,	,	,
cord-341968-uc8i9h0m	206	20	and	and	CC
cord-341968-uc8i9h0m	206	21	tropism	tropism	NN
cord-341968-uc8i9h0m	206	22	of	of	IN
cord-341968-uc8i9h0m	206	23	the	the	DT
cord-341968-uc8i9h0m	206	24	influenza	influenza	NN
cord-341968-uc8i9h0m	206	25	virus	virus	NN
cord-341968-uc8i9h0m	206	26	[	[	-LRB-
cord-341968-uc8i9h0m	206	27	105	105	CD
cord-341968-uc8i9h0m	206	28	,	,	,
cord-341968-uc8i9h0m	206	29	106	106	CD
cord-341968-uc8i9h0m	206	30	]	]	-RRB-
cord-341968-uc8i9h0m	206	31	.	.	.
cord-341968-uc8i9h0m	207	1	There	there	EX
cord-341968-uc8i9h0m	207	2	are	be	VBP
cord-341968-uc8i9h0m	207	3	16	16	CD
cord-341968-uc8i9h0m	207	4	HA	HA	NNP
cord-341968-uc8i9h0m	207	5	types	type	NNS
cord-341968-uc8i9h0m	207	6	,	,	,
cord-341968-uc8i9h0m	207	7	but	but	CC
cord-341968-uc8i9h0m	207	8	H1	h1	NN
cord-341968-uc8i9h0m	207	9	and	and	CC
cord-341968-uc8i9h0m	207	10	H2	H2	NNP
cord-341968-uc8i9h0m	207	11	are	be	VBP
cord-341968-uc8i9h0m	207	12	the	the	DT
cord-341968-uc8i9h0m	207	13	most	most	RBS
cord-341968-uc8i9h0m	207	14	commonly	commonly	RB
cord-341968-uc8i9h0m	207	15	present	present	JJ
cord-341968-uc8i9h0m	207	16	types	type	NNS
cord-341968-uc8i9h0m	207	17	in	in	IN
cord-341968-uc8i9h0m	207	18	seasonal	seasonal	JJ
cord-341968-uc8i9h0m	207	19	human	human	JJ
cord-341968-uc8i9h0m	207	20	infections	infection	NNS
cord-341968-uc8i9h0m	207	21	,	,	,
cord-341968-uc8i9h0m	207	22	other	other	JJ
cord-341968-uc8i9h0m	207	23	types	type	NNS
cord-341968-uc8i9h0m	207	24	are	be	VBP
cord-341968-uc8i9h0m	207	25	found	find	VBN
cord-341968-uc8i9h0m	207	26	in	in	IN
cord-341968-uc8i9h0m	207	27	birds	bird	NNS
cord-341968-uc8i9h0m	207	28	.	.	.
cord-341968-uc8i9h0m	208	1	The	the	DT
cord-341968-uc8i9h0m	208	2	pandemics	pandemic	NNS
cord-341968-uc8i9h0m	208	3	of	of	IN
cord-341968-uc8i9h0m	208	4	1957	1957	CD
cord-341968-uc8i9h0m	208	5	and	and	CC
cord-341968-uc8i9h0m	208	6	1968	1968	CD
cord-341968-uc8i9h0m	208	7	were	be	VBD
cord-341968-uc8i9h0m	208	8	caused	cause	VBN
cord-341968-uc8i9h0m	208	9	by	by	IN
cord-341968-uc8i9h0m	208	10	the	the	DT
cord-341968-uc8i9h0m	208	11	H2N2	H2N2	NNP
cord-341968-uc8i9h0m	208	12	and	and	CC
cord-341968-uc8i9h0m	208	13	H3N2	H3N2	NNP
cord-341968-uc8i9h0m	208	14	strains	strain	NNS
cord-341968-uc8i9h0m	208	15	,	,	,
cord-341968-uc8i9h0m	208	16	respectively	respectively	RB
cord-341968-uc8i9h0m	208	17	.	.	.
cord-341968-uc8i9h0m	209	1	The	the	DT
cord-341968-uc8i9h0m	209	2	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	209	3	cleavage	cleavage	NN
cord-341968-uc8i9h0m	209	4	of	of	IN
cord-341968-uc8i9h0m	209	5	HA	HA	NNP
cord-341968-uc8i9h0m	209	6	occurs	occur	VBZ
cord-341968-uc8i9h0m	209	7	in	in	IN
cord-341968-uc8i9h0m	209	8	a	a	DT
cord-341968-uc8i9h0m	209	9	loop	loop	NN
cord-341968-uc8i9h0m	209	10	that	that	WDT
cord-341968-uc8i9h0m	209	11	varies	vary	VBZ
cord-341968-uc8i9h0m	209	12	in	in	IN
cord-341968-uc8i9h0m	209	13	length	length	NN
cord-341968-uc8i9h0m	209	14	and	and	CC
cord-341968-uc8i9h0m	209	15	amino	amino	NN
cord-341968-uc8i9h0m	209	16	acid	acid	NN
cord-341968-uc8i9h0m	209	17	sequence	sequence	NN
cord-341968-uc8i9h0m	209	18	depending	depend	VBG
cord-341968-uc8i9h0m	209	19	on	on	IN
cord-341968-uc8i9h0m	209	20	the	the	DT
cord-341968-uc8i9h0m	209	21	strain	strain	NN
cord-341968-uc8i9h0m	209	22	(	(	-LRB-
cord-341968-uc8i9h0m	209	23	Table	table	NN
cord-341968-uc8i9h0m	209	24	5	5	CD
cord-341968-uc8i9h0m	209	25	)	)	-RRB-
cord-341968-uc8i9h0m	209	26	.	.	.
cord-341968-uc8i9h0m	210	1	The	the	DT
cord-341968-uc8i9h0m	210	2	loop	loop	NN
cord-341968-uc8i9h0m	210	3	usually	usually	RB
cord-341968-uc8i9h0m	210	4	contains	contain	VBZ
cord-341968-uc8i9h0m	210	5	one	one	CD
cord-341968-uc8i9h0m	210	6	Arg	arg	NN
cord-341968-uc8i9h0m	210	7	residue	residue	NN
cord-341968-uc8i9h0m	210	8	that	that	WDT
cord-341968-uc8i9h0m	210	9	determines	determine	VBZ
cord-341968-uc8i9h0m	210	10	cleavage	cleavage	NN
cord-341968-uc8i9h0m	210	11	by	by	IN
cord-341968-uc8i9h0m	210	12	trypsin	trypsin	NN
cord-341968-uc8i9h0m	210	13	-	-	HYPH
cord-341968-uc8i9h0m	210	14	like	like	JJ
cord-341968-uc8i9h0m	210	15	proteases	protease	NNS
cord-341968-uc8i9h0m	210	16	.	.	.
cord-341968-uc8i9h0m	211	1	The	the	DT
cord-341968-uc8i9h0m	211	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	211	3	can	can	MD
cord-341968-uc8i9h0m	211	4	occur	occur	VB
cord-341968-uc8i9h0m	211	5	during	during	IN
cord-341968-uc8i9h0m	211	6	synthesis	synthesis	NN
cord-341968-uc8i9h0m	211	7	,	,	,
cord-341968-uc8i9h0m	211	8	after	after	IN
cord-341968-uc8i9h0m	211	9	release	release	NN
cord-341968-uc8i9h0m	211	10	or	or	CC
cord-341968-uc8i9h0m	211	11	before	before	IN
cord-341968-uc8i9h0m	211	12	entry	entry	NN
cord-341968-uc8i9h0m	211	13	,	,	,
cord-341968-uc8i9h0m	211	14	and	and	CC
cord-341968-uc8i9h0m	211	15	may	may	MD
cord-341968-uc8i9h0m	211	16	depend	depend	VB
cord-341968-uc8i9h0m	211	17	on	on	IN
cord-341968-uc8i9h0m	211	18	different	different	JJ
cord-341968-uc8i9h0m	211	19	proteases	protease	NNS
cord-341968-uc8i9h0m	211	20	.	.	.
cord-341968-uc8i9h0m	212	1	The	the	DT
cord-341968-uc8i9h0m	212	2	highly	highly	RB
cord-341968-uc8i9h0m	212	3	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	212	4	virus	virus	NN
cord-341968-uc8i9h0m	212	5	strain	strain	NN
cord-341968-uc8i9h0m	212	6	responsible	responsible	JJ
cord-341968-uc8i9h0m	212	7	for	for	IN
cord-341968-uc8i9h0m	212	8	the	the	DT
cord-341968-uc8i9h0m	212	9	Spanish	spanish	JJ
cord-341968-uc8i9h0m	212	10	1918	1918	CD
cord-341968-uc8i9h0m	212	11	influenza	influenza	NN
cord-341968-uc8i9h0m	212	12	pandemic	pandemic	NN
cord-341968-uc8i9h0m	212	13	was	be	VBD
cord-341968-uc8i9h0m	212	14	of	of	IN
cord-341968-uc8i9h0m	212	15	the	the	DT
cord-341968-uc8i9h0m	212	16	H1N1	H1N1	NNP
cord-341968-uc8i9h0m	212	17	type	type	NN
cord-341968-uc8i9h0m	212	18	with	with	IN
cord-341968-uc8i9h0m	212	19	only	only	RB
cord-341968-uc8i9h0m	212	20	one	one	CD
cord-341968-uc8i9h0m	212	21	Arg	arg	NN
cord-341968-uc8i9h0m	212	22	residue	residue	NN
cord-341968-uc8i9h0m	212	23	in	in	IN
cord-341968-uc8i9h0m	212	24	its	-PRON-	PRP$
cord-341968-uc8i9h0m	212	25	cleavage	cleavage	NN
cord-341968-uc8i9h0m	212	26	loop	loop	NN
cord-341968-uc8i9h0m	212	27	.	.	.
cord-341968-uc8i9h0m	213	1	Two	two	CD
cord-341968-uc8i9h0m	213	2	proteases	protease	NNS
cord-341968-uc8i9h0m	213	3	highly	highly	RB
cord-341968-uc8i9h0m	213	4	expressed	express	VBN
cord-341968-uc8i9h0m	213	5	in	in	IN
cord-341968-uc8i9h0m	213	6	the	the	DT
cord-341968-uc8i9h0m	213	7	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	213	8	tract	tract	NN
cord-341968-uc8i9h0m	213	9	,	,	,
cord-341968-uc8i9h0m	213	10	especially	especially	RB
cord-341968-uc8i9h0m	213	11	in	in	IN
cord-341968-uc8i9h0m	213	12	the	the	DT
cord-341968-uc8i9h0m	213	13	lungs	lung	NNS
cord-341968-uc8i9h0m	213	14	,	,	,
cord-341968-uc8i9h0m	213	15	TMPRSS2	TMPRSS2	NNP
cord-341968-uc8i9h0m	213	16	and	and	CC
cord-341968-uc8i9h0m	213	17	TMPRSS4	TMPRSS4	NNP
cord-341968-uc8i9h0m	213	18	,	,	,
cord-341968-uc8i9h0m	213	19	were	be	VBD
cord-341968-uc8i9h0m	213	20	shown	show	VBN
cord-341968-uc8i9h0m	213	21	to	to	TO
cord-341968-uc8i9h0m	213	22	cleave	cleave	VB
cord-341968-uc8i9h0m	213	23	the	the	DT
cord-341968-uc8i9h0m	213	24	1918	1918	CD
cord-341968-uc8i9h0m	213	25	influenza	influenza	NN
cord-341968-uc8i9h0m	213	26	HA	HA	NNP
cord-341968-uc8i9h0m	213	27	[	[	-LRB-
cord-341968-uc8i9h0m	213	28	107	107	CD
cord-341968-uc8i9h0m	213	29	]	]	-RRB-
cord-341968-uc8i9h0m	213	30	.	.	.
cord-341968-uc8i9h0m	214	1	HAT	hat	NN
cord-341968-uc8i9h0m	214	2	is	be	VBZ
cord-341968-uc8i9h0m	214	3	a	a	DT
cord-341968-uc8i9h0m	214	4	protease	protease	NN
cord-341968-uc8i9h0m	214	5	expressed	express	VBN
cord-341968-uc8i9h0m	214	6	in	in	IN
cord-341968-uc8i9h0m	214	7	the	the	DT
cord-341968-uc8i9h0m	214	8	airways	airway	NNS
cord-341968-uc8i9h0m	214	9	,	,	,
cord-341968-uc8i9h0m	214	10	mostly	mostly	RB
cord-341968-uc8i9h0m	214	11	in	in	IN
cord-341968-uc8i9h0m	214	12	the	the	DT
cord-341968-uc8i9h0m	214	13	larynx	larynx	NN
cord-341968-uc8i9h0m	214	14	but	but	CC
cord-341968-uc8i9h0m	214	15	not	not	RB
cord-341968-uc8i9h0m	214	16	in	in	IN
cord-341968-uc8i9h0m	214	17	lungs	lung	NNS
cord-341968-uc8i9h0m	214	18	.	.	.
cord-341968-uc8i9h0m	215	1	It	-PRON-	PRP
cord-341968-uc8i9h0m	215	2	is	be	VBZ
cord-341968-uc8i9h0m	215	3	also	also	RB
cord-341968-uc8i9h0m	215	4	capable	capable	JJ
cord-341968-uc8i9h0m	215	5	of	of	IN
cord-341968-uc8i9h0m	215	6	activating	activate	VBG
cord-341968-uc8i9h0m	215	7	influenza	influenza	NN
cord-341968-uc8i9h0m	215	8	viruses	virus	NNS
cord-341968-uc8i9h0m	215	9	[	[	-LRB-
cord-341968-uc8i9h0m	215	10	108	108	CD
cord-341968-uc8i9h0m	215	11	]	]	-RRB-
cord-341968-uc8i9h0m	215	12	.	.	.
cord-341968-uc8i9h0m	216	1	Multibasic	multibasic	JJ
cord-341968-uc8i9h0m	216	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	216	3	sites	site	NNS
cord-341968-uc8i9h0m	216	4	in	in	IN
cord-341968-uc8i9h0m	216	5	HA	HA	NNP
cord-341968-uc8i9h0m	216	6	arise	arise	VB
cord-341968-uc8i9h0m	216	7	by	by	IN
cord-341968-uc8i9h0m	216	8	single	single	JJ
cord-341968-uc8i9h0m	216	9	substitution	substitution	NN
cord-341968-uc8i9h0m	216	10	mutations	mutation	NNS
cord-341968-uc8i9h0m	216	11	like	like	IN
cord-341968-uc8i9h0m	216	12	in	in	IN
cord-341968-uc8i9h0m	216	13	the	the	DT
cord-341968-uc8i9h0m	216	14	case	case	NN
cord-341968-uc8i9h0m	216	15	of	of	IN
cord-341968-uc8i9h0m	216	16	some	some	DT
cord-341968-uc8i9h0m	216	17	H9N2	H9N2	NNP
cord-341968-uc8i9h0m	216	18	types	type	NNS
cord-341968-uc8i9h0m	216	19	,	,	,
cord-341968-uc8i9h0m	216	20	or	or	CC
cord-341968-uc8i9h0m	216	21	by	by	IN
cord-341968-uc8i9h0m	216	22	insertions	insertion	NNS
cord-341968-uc8i9h0m	216	23	that	that	WDT
cord-341968-uc8i9h0m	216	24	result	result	VBP
cord-341968-uc8i9h0m	216	25	in	in	IN
cord-341968-uc8i9h0m	216	26	longer	long	JJR
cord-341968-uc8i9h0m	216	27	loops	loop	NNS
cord-341968-uc8i9h0m	216	28	,	,	,
cord-341968-uc8i9h0m	216	29	as	as	IN
cord-341968-uc8i9h0m	216	30	observed	observe	VBN
cord-341968-uc8i9h0m	216	31	with	with	IN
cord-341968-uc8i9h0m	216	32	the	the	DT
cord-341968-uc8i9h0m	216	33	highly	highly	RB
cord-341968-uc8i9h0m	216	34	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	216	35	H5	h5	NN
cord-341968-uc8i9h0m	216	36	and	and	CC
cord-341968-uc8i9h0m	216	37	H7	H7	NNP
cord-341968-uc8i9h0m	216	38	types	type	NNS
cord-341968-uc8i9h0m	216	39	.	.	.
cord-341968-uc8i9h0m	217	1	Viruses	virus	NNS
cord-341968-uc8i9h0m	217	2	that	that	WDT
cord-341968-uc8i9h0m	217	3	acquire	acquire	VBP
cord-341968-uc8i9h0m	217	4	multibasic	multibasic	NN
cord-341968-uc8i9h0m	217	5	cleavage	cleavage	NN
cord-341968-uc8i9h0m	217	6	sites	site	NNS
cord-341968-uc8i9h0m	217	7	become	become	VBP
cord-341968-uc8i9h0m	217	8	independent	independent	JJ
cord-341968-uc8i9h0m	217	9	of	of	IN
cord-341968-uc8i9h0m	217	10	trypsin	trypsin	NN
cord-341968-uc8i9h0m	217	11	-	-	HYPH
cord-341968-uc8i9h0m	217	12	like	like	JJ
cord-341968-uc8i9h0m	217	13	proteases	protease	NNS
cord-341968-uc8i9h0m	217	14	.	.	.
cord-341968-uc8i9h0m	218	1	In	in	IN
cord-341968-uc8i9h0m	218	2	low	low	RB
cord-341968-uc8i9h0m	218	3	-	-	HYPH
cord-341968-uc8i9h0m	218	4	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	218	5	H9N2	H9N2	NNP
cord-341968-uc8i9h0m	218	6	strains	strain	NNS
cord-341968-uc8i9h0m	218	7	carrying	carry	VBG
cord-341968-uc8i9h0m	218	8	the	the	DT
cord-341968-uc8i9h0m	218	9	cleavage	cleavage	NN
cord-341968-uc8i9h0m	218	10	site	site	NN
cord-341968-uc8i9h0m	218	11	motif	motif	NN
cord-341968-uc8i9h0m	218	12	,	,	,
cord-341968-uc8i9h0m	218	13	R	r	NN
cord-341968-uc8i9h0m	218	14	-	-	HYPH
cord-341968-uc8i9h0m	218	15	S	s	NN
cord-341968-uc8i9h0m	218	16	-	-	HYPH
cord-341968-uc8i9h0m	218	17	K	K	NNP
cord-341968-uc8i9h0m	218	18	-	-	HYPH
cord-341968-uc8i9h0m	218	19	R	r	NN
cord-341968-uc8i9h0m	218	20	,	,	,
cord-341968-uc8i9h0m	218	21	cleavage	cleavage	NN
cord-341968-uc8i9h0m	218	22	is	be	VBZ
cord-341968-uc8i9h0m	218	23	not	not	RB
cord-341968-uc8i9h0m	218	24	performed	perform	VBN
cord-341968-uc8i9h0m	218	25	by	by	IN
cord-341968-uc8i9h0m	218	26	PCs	pc	NNS
cord-341968-uc8i9h0m	218	27	but	but	CC
cord-341968-uc8i9h0m	218	28	by	by	IN
cord-341968-uc8i9h0m	218	29	matriptase	matriptase	NNP
cord-341968-uc8i9h0m	218	30	,	,	,
cord-341968-uc8i9h0m	218	31	which	which	WDT
cord-341968-uc8i9h0m	218	32	recognizes	recognize	VBZ
cord-341968-uc8i9h0m	218	33	the	the	DT
cord-341968-uc8i9h0m	218	34	same	same	JJ
cord-341968-uc8i9h0m	218	35	cleavage	cleavage	NN
cord-341968-uc8i9h0m	218	36	site	site	NN
cord-341968-uc8i9h0m	218	37	motif	motif	NN
cord-341968-uc8i9h0m	218	38	of	of	IN
cord-341968-uc8i9h0m	218	39	PCs	pc	NNS
cord-341968-uc8i9h0m	218	40	and	and	CC
cord-341968-uc8i9h0m	218	41	determines	determine	VBZ
cord-341968-uc8i9h0m	218	42	the	the	DT
cord-341968-uc8i9h0m	218	43	nephrotropism	nephrotropism	NN
cord-341968-uc8i9h0m	218	44	of	of	IN
cord-341968-uc8i9h0m	218	45	the	the	DT
cord-341968-uc8i9h0m	218	46	virus	virus	NN
cord-341968-uc8i9h0m	218	47	[	[	-LRB-
cord-341968-uc8i9h0m	218	48	109	109	CD
cord-341968-uc8i9h0m	218	49	]	]	-RRB-
cord-341968-uc8i9h0m	218	50	.	.	.
cord-341968-uc8i9h0m	219	1	However	however	RB
cord-341968-uc8i9h0m	219	2	,	,	,
cord-341968-uc8i9h0m	219	3	H9N2	H9N2	NNP
cord-341968-uc8i9h0m	219	4	can	can	MD
cord-341968-uc8i9h0m	219	5	become	become	VB
cord-341968-uc8i9h0m	219	6	reactive	reactive	JJ
cord-341968-uc8i9h0m	219	7	with	with	IN
cord-341968-uc8i9h0m	219	8	PCs	pc	NNS
cord-341968-uc8i9h0m	219	9	by	by	IN
cord-341968-uc8i9h0m	219	10	the	the	DT
cord-341968-uc8i9h0m	219	11	removal	removal	NN
cord-341968-uc8i9h0m	219	12	of	of	IN
cord-341968-uc8i9h0m	219	13	a	a	DT
cord-341968-uc8i9h0m	219	14	glycosylation	glycosylation	NN
cord-341968-uc8i9h0m	219	15	site	site	NN
cord-341968-uc8i9h0m	219	16	near	near	IN
cord-341968-uc8i9h0m	219	17	the	the	DT
cord-341968-uc8i9h0m	219	18	cleavage	cleavage	NN
cord-341968-uc8i9h0m	219	19	site	site	NN
cord-341968-uc8i9h0m	219	20	[	[	-LRB-
cord-341968-uc8i9h0m	219	21	110	110	CD
cord-341968-uc8i9h0m	219	22	]	]	-RRB-
cord-341968-uc8i9h0m	219	23	.	.	.
cord-341968-uc8i9h0m	220	1	The	the	DT
cord-341968-uc8i9h0m	220	2	long	long	JJ
cord-341968-uc8i9h0m	220	3	and	and	CC
cord-341968-uc8i9h0m	220	4	multibasic	multibasic	NN
cord-341968-uc8i9h0m	220	5	loops	loop	NNS
cord-341968-uc8i9h0m	220	6	in	in	IN
cord-341968-uc8i9h0m	220	7	some	some	DT
cord-341968-uc8i9h0m	220	8	H5	h5	NN
cord-341968-uc8i9h0m	220	9	and	and	CC
cord-341968-uc8i9h0m	220	10	H7	h7	NN
cord-341968-uc8i9h0m	220	11	strains	strain	NNS
cord-341968-uc8i9h0m	220	12	are	be	VBP
cord-341968-uc8i9h0m	220	13	highly	highly	RB
cord-341968-uc8i9h0m	220	14	reactive	reactive	JJ
cord-341968-uc8i9h0m	220	15	with	with	IN
cord-341968-uc8i9h0m	220	16	furin	furin	NN
cord-341968-uc8i9h0m	220	17	[	[	-LRB-
cord-341968-uc8i9h0m	220	18	111	111	CD
cord-341968-uc8i9h0m	220	19	]	]	-RRB-
cord-341968-uc8i9h0m	220	20	[	[	-LRB-
cord-341968-uc8i9h0m	220	21	112	112	CD
cord-341968-uc8i9h0m	220	22	]	]	-RRB-
cord-341968-uc8i9h0m	220	23	[	[	-LRB-
cord-341968-uc8i9h0m	220	24	113	113	CD
cord-341968-uc8i9h0m	220	25	]	]	-RRB-
cord-341968-uc8i9h0m	220	26	[	[	-LRB-
cord-341968-uc8i9h0m	220	27	114	114	CD
cord-341968-uc8i9h0m	220	28	]	]	-RRB-
cord-341968-uc8i9h0m	220	29	;	;	:
cord-341968-uc8i9h0m	220	30	this	this	DT
cord-341968-uc8i9h0m	220	31	reactivity	reactivity	NN
cord-341968-uc8i9h0m	220	32	leads	lead	VBZ
cord-341968-uc8i9h0m	220	33	to	to	IN
cord-341968-uc8i9h0m	220	34	high	high	JJ
cord-341968-uc8i9h0m	220	35	pathogenicity	pathogenicity	NN
cord-341968-uc8i9h0m	220	36	that	that	WDT
cord-341968-uc8i9h0m	220	37	causes	cause	VBZ
cord-341968-uc8i9h0m	220	38	systemic	systemic	JJ
cord-341968-uc8i9h0m	220	39	infections	infection	NNS
cord-341968-uc8i9h0m	220	40	[	[	-LRB-
cord-341968-uc8i9h0m	220	41	115	115	CD
cord-341968-uc8i9h0m	220	42	,	,	,
cord-341968-uc8i9h0m	220	43	116	116	CD
cord-341968-uc8i9h0m	220	44	]	]	-RRB-
cord-341968-uc8i9h0m	220	45	.	.	.
cord-341968-uc8i9h0m	221	1	An	an	DT
cord-341968-uc8i9h0m	221	2	outbreak	outbreak	NN
cord-341968-uc8i9h0m	221	3	of	of	IN
cord-341968-uc8i9h0m	221	4	a	a	DT
cord-341968-uc8i9h0m	221	5	highly	highly	RB
cord-341968-uc8i9h0m	221	6	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	221	7	avian	avian	JJ
cord-341968-uc8i9h0m	221	8	H5N1	H5N1	NNP
cord-341968-uc8i9h0m	221	9	strain	strain	NN
cord-341968-uc8i9h0m	221	10	that	that	IN
cord-341968-uc8i9h0m	221	11	infected	infected	JJ
cord-341968-uc8i9h0m	221	12	humans	human	NNS
cord-341968-uc8i9h0m	221	13	occurred	occur	VBD
cord-341968-uc8i9h0m	221	14	in	in	IN
cord-341968-uc8i9h0m	221	15	1997	1997	CD
cord-341968-uc8i9h0m	221	16	in	in	IN
cord-341968-uc8i9h0m	221	17	Hong	Hong	NNP
cord-341968-uc8i9h0m	221	18	Kong	Kong	NNP
cord-341968-uc8i9h0m	221	19	.	.	.
cord-341968-uc8i9h0m	222	1	In	in	IN
cord-341968-uc8i9h0m	222	2	some	some	DT
cord-341968-uc8i9h0m	222	3	highly	highly	RB
cord-341968-uc8i9h0m	222	4	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	222	5	H5	h5	NN
cord-341968-uc8i9h0m	222	6	and	and	CC
cord-341968-uc8i9h0m	222	7	H7	H7	NNP
cord-341968-uc8i9h0m	222	8	types	type	NNS
cord-341968-uc8i9h0m	222	9	that	that	WDT
cord-341968-uc8i9h0m	222	10	have	have	VBP
cord-341968-uc8i9h0m	222	11	the	the	DT
cord-341968-uc8i9h0m	222	12	K	K	NNP
cord-341968-uc8i9h0m	222	13	-	-	HYPH
cord-341968-uc8i9h0m	222	14	K	K	NNP
cord-341968-uc8i9h0m	222	15	-	-	HYPH
cord-341968-uc8i9h0m	222	16	K	k	NN
cord-341968-uc8i9h0m	222	17	-	-	HYPH
cord-341968-uc8i9h0m	222	18	R	r	NN
cord-341968-uc8i9h0m	222	19	motif	motif	NN
cord-341968-uc8i9h0m	222	20	,	,	,
cord-341968-uc8i9h0m	222	21	cleavage	cleavage	NN
cord-341968-uc8i9h0m	222	22	is	be	VBZ
cord-341968-uc8i9h0m	222	23	carried	carry	VBN
cord-341968-uc8i9h0m	222	24	out	out	RP
cord-341968-uc8i9h0m	222	25	by	by	IN
cord-341968-uc8i9h0m	222	26	the	the	DT
cord-341968-uc8i9h0m	222	27	ubiquitous	ubiquitous	JJ
cord-341968-uc8i9h0m	222	28	protease	protease	NN
cord-341968-uc8i9h0m	222	29	MSPL	MSPL	NNP
cord-341968-uc8i9h0m	222	30	and	and	CC
cord-341968-uc8i9h0m	222	31	its	-PRON-	PRP$
cord-341968-uc8i9h0m	222	32	splice	splice	NN
cord-341968-uc8i9h0m	222	33	variant	variant	NN
cord-341968-uc8i9h0m	222	34	MTPRSS13	MTPRSS13	NNP
cord-341968-uc8i9h0m	222	35	,	,	,
cord-341968-uc8i9h0m	222	36	which	which	WDT
cord-341968-uc8i9h0m	222	37	are	be	VBP
cord-341968-uc8i9h0m	222	38	also	also	RB
cord-341968-uc8i9h0m	222	39	capable	capable	JJ
cord-341968-uc8i9h0m	222	40	of	of	IN
cord-341968-uc8i9h0m	222	41	cleaving	cleave	VBG
cord-341968-uc8i9h0m	222	42	at	at	IN
cord-341968-uc8i9h0m	222	43	the	the	DT
cord-341968-uc8i9h0m	222	44	PC	pc	NN
cord-341968-uc8i9h0m	222	45	cleavage	cleavage	NN
cord-341968-uc8i9h0m	222	46	site	site	NN
cord-341968-uc8i9h0m	222	47	motif	motif	NN
cord-341968-uc8i9h0m	222	48	[	[	-LRB-
cord-341968-uc8i9h0m	222	49	117	117	CD
cord-341968-uc8i9h0m	222	50	]	]	-RRB-
cord-341968-uc8i9h0m	222	51	.	.	.
cord-341968-uc8i9h0m	223	1	Table	table	NN
cord-341968-uc8i9h0m	223	2	5	5	CD
cord-341968-uc8i9h0m	223	3	.	.	.
cord-341968-uc8i9h0m	224	1	Cleavage	cleavage	NN
cord-341968-uc8i9h0m	224	2	loop	loop	NN
cord-341968-uc8i9h0m	224	3	in	in	IN
cord-341968-uc8i9h0m	224	4	the	the	DT
cord-341968-uc8i9h0m	224	5	HA	HA	NNP
cord-341968-uc8i9h0m	224	6	protein	protein	NN
cord-341968-uc8i9h0m	224	7	of	of	IN
cord-341968-uc8i9h0m	224	8	influenza	influenza	NN
cord-341968-uc8i9h0m	224	9	viruses	virus	NNS
cord-341968-uc8i9h0m	224	10	.	.	.
cord-341968-uc8i9h0m	225	1	The	the	DT
cord-341968-uc8i9h0m	225	2	variable	variable	JJ
cord-341968-uc8i9h0m	225	3	region	region	NN
cord-341968-uc8i9h0m	225	4	is	be	VBZ
cord-341968-uc8i9h0m	225	5	blue	blue	JJ
cord-341968-uc8i9h0m	225	6	with	with	IN
cord-341968-uc8i9h0m	225	7	the	the	DT
cord-341968-uc8i9h0m	225	8	arrow	arrow	NN
cord-341968-uc8i9h0m	225	9	denoting	denote	VBG
cord-341968-uc8i9h0m	225	10	the	the	DT
cord-341968-uc8i9h0m	225	11	cleavage	cleavage	NN
cord-341968-uc8i9h0m	225	12	site	site	NN
cord-341968-uc8i9h0m	225	13	.	.	.
cord-341968-uc8i9h0m	226	1	The	the	DT
cord-341968-uc8i9h0m	226	2	P4Arg	P4Arg	NNP
cord-341968-uc8i9h0m	226	3	and	and	CC
cord-341968-uc8i9h0m	226	4	P1Arg	p1arg	NN
cord-341968-uc8i9h0m	226	5	residues	residue	NNS
cord-341968-uc8i9h0m	226	6	are	be	VBP
cord-341968-uc8i9h0m	226	7	colored	color	VBN
cord-341968-uc8i9h0m	226	8	red	red	JJ
cord-341968-uc8i9h0m	226	9	.	.	.
cord-341968-uc8i9h0m	227	1	Figure	figure	NN
cord-341968-uc8i9h0m	227	2	3	3	CD
cord-341968-uc8i9h0m	227	3	.	.	.
cord-341968-uc8i9h0m	228	1	X	x	NN
cord-341968-uc8i9h0m	228	2	-	-	NN
cord-341968-uc8i9h0m	228	3	ray	ray	NN
cord-341968-uc8i9h0m	228	4	crystal	crystal	NN
cord-341968-uc8i9h0m	228	5	structure	structure	NN
cord-341968-uc8i9h0m	228	6	of	of	IN
cord-341968-uc8i9h0m	228	7	the	the	DT
cord-341968-uc8i9h0m	228	8	HA	HA	NNP
cord-341968-uc8i9h0m	228	9	trimer	trimer	NN
cord-341968-uc8i9h0m	228	10	from	from	IN
cord-341968-uc8i9h0m	228	11	the	the	DT
cord-341968-uc8i9h0m	228	12	influenza	influenza	NN
cord-341968-uc8i9h0m	228	13	virus	virus	NN
cord-341968-uc8i9h0m	229	1	A	a	DT
cord-341968-uc8i9h0m	229	2	type	type	NN
cord-341968-uc8i9h0m	229	3	H5	h5	NN
cord-341968-uc8i9h0m	229	4	.	.	.
cord-341968-uc8i9h0m	230	1	Each	each	DT
cord-341968-uc8i9h0m	230	2	HA	HA	NNP
cord-341968-uc8i9h0m	230	3	monomer	monomer	NN
cord-341968-uc8i9h0m	230	4	is	be	VBZ
cord-341968-uc8i9h0m	230	5	divided	divide	VBN
cord-341968-uc8i9h0m	230	6	into	into	IN
cord-341968-uc8i9h0m	230	7	HA1	HA1	NNP
cord-341968-uc8i9h0m	230	8	(	(	-LRB-
cord-341968-uc8i9h0m	230	9	red	red	JJ
cord-341968-uc8i9h0m	230	10	,	,	,
cord-341968-uc8i9h0m	230	11	blue	blue	JJ
cord-341968-uc8i9h0m	230	12	,	,	,
cord-341968-uc8i9h0m	230	13	and	and	CC
cord-341968-uc8i9h0m	230	14	gray	gray	JJ
cord-341968-uc8i9h0m	230	15	)	)	-RRB-
cord-341968-uc8i9h0m	230	16	and	and	CC
cord-341968-uc8i9h0m	230	17	HA2	HA2	NNP
cord-341968-uc8i9h0m	230	18	(	(	-LRB-
cord-341968-uc8i9h0m	230	19	oarange	oarange	NNP
cord-341968-uc8i9h0m	230	20	,	,	,
cord-341968-uc8i9h0m	230	21	cyan	cyan	NNP
cord-341968-uc8i9h0m	230	22	,	,	,
cord-341968-uc8i9h0m	230	23	and	and	CC
cord-341968-uc8i9h0m	230	24	white	white	JJ
cord-341968-uc8i9h0m	230	25	,	,	,
cord-341968-uc8i9h0m	230	26	respectively	respectively	RB
cord-341968-uc8i9h0m	230	27	)	)	-RRB-
cord-341968-uc8i9h0m	230	28	subunits	subunit	NNS
cord-341968-uc8i9h0m	230	29	after	after	IN
cord-341968-uc8i9h0m	230	30	the	the	DT
cord-341968-uc8i9h0m	230	31	PC	pc	NN
cord-341968-uc8i9h0m	230	32	cleavage	cleavage	NN
cord-341968-uc8i9h0m	230	33	denoted	denote	VBN
cord-341968-uc8i9h0m	230	34	by	by	IN
cord-341968-uc8i9h0m	230	35	residues	residue	NNS
cord-341968-uc8i9h0m	230	36	at	at	IN
cord-341968-uc8i9h0m	230	37	the	the	DT
cord-341968-uc8i9h0m	230	38	end	end	NN
cord-341968-uc8i9h0m	230	39	HA1	HA1	NNP
cord-341968-uc8i9h0m	230	40	(	(	-LRB-
cord-341968-uc8i9h0m	230	41	yellow	yellow	NNP
cord-341968-uc8i9h0m	230	42	)	)	-RRB-
cord-341968-uc8i9h0m	230	43	and	and	CC
cord-341968-uc8i9h0m	230	44	the	the	DT
cord-341968-uc8i9h0m	230	45	beginning	beginning	NN
cord-341968-uc8i9h0m	230	46	of	of	IN
cord-341968-uc8i9h0m	230	47	HA2	HA2	NNP
cord-341968-uc8i9h0m	230	48	(	(	-LRB-
cord-341968-uc8i9h0m	230	49	purple	purple	NN
cord-341968-uc8i9h0m	230	50	)	)	-RRB-
cord-341968-uc8i9h0m	230	51	.	.	.
cord-341968-uc8i9h0m	231	1	PDB	PDB	NNP
cord-341968-uc8i9h0m	231	2	ID	ID	NNP
cord-341968-uc8i9h0m	231	3	code	code	NN
cord-341968-uc8i9h0m	231	4	2IBX	2ibx	NN
cord-341968-uc8i9h0m	231	5	.	.	.
cord-341968-uc8i9h0m	232	1	Multibasic	multibasic	JJ
cord-341968-uc8i9h0m	232	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	232	3	sites	site	NNS
cord-341968-uc8i9h0m	232	4	in	in	IN
cord-341968-uc8i9h0m	232	5	HA	HA	NNP
cord-341968-uc8i9h0m	232	6	arise	arise	VB
cord-341968-uc8i9h0m	232	7	by	by	IN
cord-341968-uc8i9h0m	232	8	single	single	JJ
cord-341968-uc8i9h0m	232	9	substitution	substitution	NN
cord-341968-uc8i9h0m	232	10	mutations	mutation	NNS
cord-341968-uc8i9h0m	232	11	like	like	IN
cord-341968-uc8i9h0m	232	12	in	in	IN
cord-341968-uc8i9h0m	232	13	the	the	DT
cord-341968-uc8i9h0m	232	14	case	case	NN
cord-341968-uc8i9h0m	232	15	of	of	IN
cord-341968-uc8i9h0m	232	16	some	some	DT
cord-341968-uc8i9h0m	232	17	H9N2	H9N2	NNP
cord-341968-uc8i9h0m	232	18	types	type	NNS
cord-341968-uc8i9h0m	232	19	,	,	,
cord-341968-uc8i9h0m	232	20	or	or	CC
cord-341968-uc8i9h0m	232	21	by	by	IN
cord-341968-uc8i9h0m	232	22	insertions	insertion	NNS
cord-341968-uc8i9h0m	232	23	that	that	WDT
cord-341968-uc8i9h0m	232	24	result	result	VBP
cord-341968-uc8i9h0m	232	25	in	in	IN
cord-341968-uc8i9h0m	232	26	longer	long	JJR
cord-341968-uc8i9h0m	232	27	loops	loop	NNS
cord-341968-uc8i9h0m	232	28	,	,	,
cord-341968-uc8i9h0m	232	29	as	as	IN
cord-341968-uc8i9h0m	232	30	observed	observe	VBN
cord-341968-uc8i9h0m	232	31	with	with	IN
cord-341968-uc8i9h0m	232	32	the	the	DT
cord-341968-uc8i9h0m	232	33	highly	highly	RB
cord-341968-uc8i9h0m	232	34	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	232	35	H5	h5	NN
cord-341968-uc8i9h0m	232	36	and	and	CC
cord-341968-uc8i9h0m	232	37	H7	H7	NNP
cord-341968-uc8i9h0m	232	38	types	type	NNS
cord-341968-uc8i9h0m	232	39	.	.	.
cord-341968-uc8i9h0m	233	1	Viruses	virus	NNS
cord-341968-uc8i9h0m	233	2	that	that	WDT
cord-341968-uc8i9h0m	233	3	acquire	acquire	VBP
cord-341968-uc8i9h0m	233	4	multibasic	multibasic	NN
cord-341968-uc8i9h0m	233	5	cleavage	cleavage	NN
cord-341968-uc8i9h0m	233	6	sites	site	NNS
cord-341968-uc8i9h0m	233	7	become	become	VBP
cord-341968-uc8i9h0m	233	8	independent	independent	JJ
cord-341968-uc8i9h0m	233	9	of	of	IN
cord-341968-uc8i9h0m	233	10	trypsin	trypsin	NN
cord-341968-uc8i9h0m	233	11	-	-	HYPH
cord-341968-uc8i9h0m	233	12	like	like	JJ
cord-341968-uc8i9h0m	233	13	proteases	protease	NNS
cord-341968-uc8i9h0m	233	14	.	.	.
cord-341968-uc8i9h0m	234	1	In	in	IN
cord-341968-uc8i9h0m	234	2	low	low	RB
cord-341968-uc8i9h0m	234	3	-	-	HYPH
cord-341968-uc8i9h0m	234	4	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	234	5	H9N2	H9N2	NNP
cord-341968-uc8i9h0m	234	6	strains	strain	NNS
cord-341968-uc8i9h0m	234	7	carrying	carry	VBG
cord-341968-uc8i9h0m	234	8	the	the	DT
cord-341968-uc8i9h0m	234	9	cleavage	cleavage	NN
cord-341968-uc8i9h0m	234	10	site	site	NN
cord-341968-uc8i9h0m	234	11	motif	motif	NN
cord-341968-uc8i9h0m	234	12	,	,	,
cord-341968-uc8i9h0m	234	13	R	r	NN
cord-341968-uc8i9h0m	234	14	-	-	HYPH
cord-341968-uc8i9h0m	234	15	S	s	NN
cord-341968-uc8i9h0m	234	16	-	-	HYPH
cord-341968-uc8i9h0m	234	17	K	K	NNP
cord-341968-uc8i9h0m	234	18	-	-	HYPH
cord-341968-uc8i9h0m	234	19	R	r	NN
cord-341968-uc8i9h0m	234	20	,	,	,
cord-341968-uc8i9h0m	234	21	cleavage	cleavage	NN
cord-341968-uc8i9h0m	234	22	is	be	VBZ
cord-341968-uc8i9h0m	234	23	not	not	RB
cord-341968-uc8i9h0m	234	24	performed	perform	VBN
cord-341968-uc8i9h0m	234	25	by	by	IN
cord-341968-uc8i9h0m	234	26	PCs	pc	NNS
cord-341968-uc8i9h0m	234	27	but	but	CC
cord-341968-uc8i9h0m	234	28	by	by	IN
cord-341968-uc8i9h0m	234	29	matriptase	matriptase	NNP
cord-341968-uc8i9h0m	234	30	,	,	,
cord-341968-uc8i9h0m	234	31	which	which	WDT
cord-341968-uc8i9h0m	234	32	Figure	figure	NN
cord-341968-uc8i9h0m	234	33	3	3	CD
cord-341968-uc8i9h0m	234	34	.	.	.
cord-341968-uc8i9h0m	235	1	X	x	NN
cord-341968-uc8i9h0m	235	2	-	-	NN
cord-341968-uc8i9h0m	235	3	ray	ray	NN
cord-341968-uc8i9h0m	235	4	crystal	crystal	NN
cord-341968-uc8i9h0m	235	5	structure	structure	NN
cord-341968-uc8i9h0m	235	6	of	of	IN
cord-341968-uc8i9h0m	235	7	the	the	DT
cord-341968-uc8i9h0m	235	8	HA	HA	NNP
cord-341968-uc8i9h0m	235	9	trimer	trimer	NN
cord-341968-uc8i9h0m	235	10	from	from	IN
cord-341968-uc8i9h0m	235	11	the	the	DT
cord-341968-uc8i9h0m	235	12	influenza	influenza	NN
cord-341968-uc8i9h0m	235	13	virus	virus	NN
cord-341968-uc8i9h0m	236	1	A	a	DT
cord-341968-uc8i9h0m	236	2	type	type	NN
cord-341968-uc8i9h0m	236	3	H5	h5	NN
cord-341968-uc8i9h0m	236	4	.	.	.
cord-341968-uc8i9h0m	237	1	Each	each	DT
cord-341968-uc8i9h0m	237	2	HA	HA	NNP
cord-341968-uc8i9h0m	237	3	monomer	monomer	NN
cord-341968-uc8i9h0m	237	4	is	be	VBZ
cord-341968-uc8i9h0m	237	5	divided	divide	VBN
cord-341968-uc8i9h0m	237	6	into	into	IN
cord-341968-uc8i9h0m	237	7	HA	HA	NNP
cord-341968-uc8i9h0m	237	8	1	1	CD
cord-341968-uc8i9h0m	237	9	(	(	-LRB-
cord-341968-uc8i9h0m	237	10	red	red	JJ
cord-341968-uc8i9h0m	237	11	,	,	,
cord-341968-uc8i9h0m	237	12	blue	blue	JJ
cord-341968-uc8i9h0m	237	13	,	,	,
cord-341968-uc8i9h0m	237	14	and	and	CC
cord-341968-uc8i9h0m	237	15	gray	gray	JJ
cord-341968-uc8i9h0m	237	16	)	)	-RRB-
cord-341968-uc8i9h0m	237	17	and	and	CC
cord-341968-uc8i9h0m	237	18	HA	HA	NNP
cord-341968-uc8i9h0m	237	19	2	2	CD
cord-341968-uc8i9h0m	237	20	(	(	-LRB-
cord-341968-uc8i9h0m	237	21	oarange	oarange	NNP
cord-341968-uc8i9h0m	237	22	,	,	,
cord-341968-uc8i9h0m	237	23	cyan	cyan	NNP
cord-341968-uc8i9h0m	237	24	,	,	,
cord-341968-uc8i9h0m	237	25	and	and	CC
cord-341968-uc8i9h0m	237	26	white	white	JJ
cord-341968-uc8i9h0m	237	27	,	,	,
cord-341968-uc8i9h0m	237	28	respectively	respectively	RB
cord-341968-uc8i9h0m	237	29	)	)	-RRB-
cord-341968-uc8i9h0m	237	30	subunits	subunit	NNS
cord-341968-uc8i9h0m	237	31	after	after	IN
cord-341968-uc8i9h0m	237	32	the	the	DT
cord-341968-uc8i9h0m	237	33	PC	pc	NN
cord-341968-uc8i9h0m	237	34	cleavage	cleavage	NN
cord-341968-uc8i9h0m	237	35	denoted	denote	VBN
cord-341968-uc8i9h0m	237	36	by	by	IN
cord-341968-uc8i9h0m	237	37	residues	residue	NNS
cord-341968-uc8i9h0m	237	38	at	at	IN
cord-341968-uc8i9h0m	237	39	the	the	DT
cord-341968-uc8i9h0m	237	40	end	end	NN
cord-341968-uc8i9h0m	237	41	HA	HA	NNP
cord-341968-uc8i9h0m	237	42	1	1	CD
cord-341968-uc8i9h0m	237	43	(	(	-LRB-
cord-341968-uc8i9h0m	237	44	yellow	yellow	NNP
cord-341968-uc8i9h0m	237	45	)	)	-RRB-
cord-341968-uc8i9h0m	237	46	and	and	CC
cord-341968-uc8i9h0m	237	47	the	the	DT
cord-341968-uc8i9h0m	237	48	beginning	beginning	NN
cord-341968-uc8i9h0m	237	49	of	of	IN
cord-341968-uc8i9h0m	237	50	HA	HA	NNP
cord-341968-uc8i9h0m	237	51	2	2	CD
cord-341968-uc8i9h0m	237	52	(	(	-LRB-
cord-341968-uc8i9h0m	237	53	purple	purple	NN
cord-341968-uc8i9h0m	237	54	)	)	-RRB-
cord-341968-uc8i9h0m	237	55	.	.	.
cord-341968-uc8i9h0m	238	1	PDB	PDB	NNP
cord-341968-uc8i9h0m	238	2	ID	ID	NNP
cord-341968-uc8i9h0m	238	3	code	code	NN
cord-341968-uc8i9h0m	238	4	2IBX	2ibx	NN
cord-341968-uc8i9h0m	238	5	.	.	.
cord-341968-uc8i9h0m	239	1	The	the	DT
cord-341968-uc8i9h0m	239	2	search	search	NN
cord-341968-uc8i9h0m	239	3	for	for	IN
cord-341968-uc8i9h0m	239	4	effective	effective	JJ
cord-341968-uc8i9h0m	239	5	PC	pc	NN
cord-341968-uc8i9h0m	239	6	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	239	7	centers	center	NNS
cord-341968-uc8i9h0m	239	8	into	into	IN
cord-341968-uc8i9h0m	239	9	finding	find	VBG
cord-341968-uc8i9h0m	239	10	the	the	DT
cord-341968-uc8i9h0m	239	11	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	239	12	with	with	IN
cord-341968-uc8i9h0m	239	13	the	the	DT
cord-341968-uc8i9h0m	239	14	best	good	JJS
cord-341968-uc8i9h0m	239	15	characteristics	characteristic	NNS
cord-341968-uc8i9h0m	239	16	of	of	IN
cord-341968-uc8i9h0m	239	17	specificity	specificity	NN
cord-341968-uc8i9h0m	239	18	,	,	,
cord-341968-uc8i9h0m	239	19	stability	stability	NN
cord-341968-uc8i9h0m	239	20	,	,	,
cord-341968-uc8i9h0m	239	21	and	and	CC
cord-341968-uc8i9h0m	239	22	bioavailability	bioavailability	NN
cord-341968-uc8i9h0m	239	23	[	[	-LRB-
cord-341968-uc8i9h0m	239	24	118	118	CD
cord-341968-uc8i9h0m	239	25	]	]	-RRB-
cord-341968-uc8i9h0m	239	26	.	.	.
cord-341968-uc8i9h0m	240	1	Most	Most	JJS
cord-341968-uc8i9h0m	240	2	PC	pc	NN
cord-341968-uc8i9h0m	240	3	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	240	4	reported	report	VBD
cord-341968-uc8i9h0m	240	5	have	have	VBP
cord-341968-uc8i9h0m	240	6	been	be	VBN
cord-341968-uc8i9h0m	240	7	developed	develop	VBN
cord-341968-uc8i9h0m	240	8	against	against	IN
cord-341968-uc8i9h0m	240	9	furin	furin	NN
cord-341968-uc8i9h0m	240	10	.	.	.
cord-341968-uc8i9h0m	241	1	Although	although	IN
cord-341968-uc8i9h0m	241	2	these	these	DT
cord-341968-uc8i9h0m	241	3	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	241	4	are	be	VBP
cord-341968-uc8i9h0m	241	5	of	of	IN
cord-341968-uc8i9h0m	241	6	high	high	JJ
cord-341968-uc8i9h0m	241	7	PC	pc	NN
cord-341968-uc8i9h0m	241	8	specificity	specificity	NN
cord-341968-uc8i9h0m	241	9	,	,	,
cord-341968-uc8i9h0m	241	10	many	many	JJ
cord-341968-uc8i9h0m	241	11	of	of	IN
cord-341968-uc8i9h0m	241	12	them	-PRON-	PRP
cord-341968-uc8i9h0m	241	13	still	still	RB
cord-341968-uc8i9h0m	241	14	lack	lack	VBP
cord-341968-uc8i9h0m	241	15	proper	proper	JJ
cord-341968-uc8i9h0m	241	16	characterization	characterization	NN
cord-341968-uc8i9h0m	241	17	of	of	IN
cord-341968-uc8i9h0m	241	18	their	-PRON-	PRP$
cord-341968-uc8i9h0m	241	19	PC	pc	NN
cord-341968-uc8i9h0m	241	20	selectivity	selectivity	NN
cord-341968-uc8i9h0m	241	21	.	.	.
cord-341968-uc8i9h0m	242	1	Knowing	know	VBG
cord-341968-uc8i9h0m	242	2	the	the	DT
cord-341968-uc8i9h0m	242	3	PC	pc	NN
cord-341968-uc8i9h0m	242	4	selectivity	selectivity	NN
cord-341968-uc8i9h0m	242	5	of	of	IN
cord-341968-uc8i9h0m	242	6	an	an	DT
cord-341968-uc8i9h0m	242	7	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	242	8	is	be	VBZ
cord-341968-uc8i9h0m	242	9	a	a	DT
cord-341968-uc8i9h0m	242	10	critical	critical	JJ
cord-341968-uc8i9h0m	242	11	issue	issue	NN
cord-341968-uc8i9h0m	242	12	as	as	IN
cord-341968-uc8i9h0m	242	13	PCs	pc	NNS
cord-341968-uc8i9h0m	242	14	differ	differ	VBP
cord-341968-uc8i9h0m	242	15	in	in	IN
cord-341968-uc8i9h0m	242	16	substrate	substrate	JJ
cord-341968-uc8i9h0m	242	17	specificity	specificity	NN
cord-341968-uc8i9h0m	242	18	,	,	,
cord-341968-uc8i9h0m	242	19	and	and	CC
cord-341968-uc8i9h0m	242	20	viruses	virus	NNS
cord-341968-uc8i9h0m	242	21	can	can	MD
cord-341968-uc8i9h0m	242	22	be	be	VB
cord-341968-uc8i9h0m	242	23	PC	pc	NN
cord-341968-uc8i9h0m	242	24	-	-	HYPH
cord-341968-uc8i9h0m	242	25	selective	selective	JJ
cord-341968-uc8i9h0m	242	26	.	.	.
cord-341968-uc8i9h0m	243	1	Synthetic	synthetic	JJ
cord-341968-uc8i9h0m	243	2	PC	pc	NN
cord-341968-uc8i9h0m	243	3	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	243	4	come	come	VBP
cord-341968-uc8i9h0m	243	5	in	in	IN
cord-341968-uc8i9h0m	243	6	several	several	JJ
cord-341968-uc8i9h0m	243	7	forms	form	NNS
cord-341968-uc8i9h0m	243	8	,	,	,
cord-341968-uc8i9h0m	243	9	from	from	IN
cord-341968-uc8i9h0m	243	10	small	small	JJ
cord-341968-uc8i9h0m	243	11	molecules	molecule	NNS
cord-341968-uc8i9h0m	243	12	identified	identify	VBN
cord-341968-uc8i9h0m	243	13	by	by	IN
cord-341968-uc8i9h0m	243	14	high	high	JJ
cord-341968-uc8i9h0m	243	15	-	-	HYPH
cord-341968-uc8i9h0m	243	16	throughput	throughput	NN
cord-341968-uc8i9h0m	243	17	screening	screening	NN
cord-341968-uc8i9h0m	243	18	[	[	-LRB-
cord-341968-uc8i9h0m	243	19	119	119	CD
cord-341968-uc8i9h0m	243	20	]	]	-RRB-
cord-341968-uc8i9h0m	243	21	[	[	-LRB-
cord-341968-uc8i9h0m	243	22	120	120	CD
cord-341968-uc8i9h0m	243	23	]	]	-RRB-
cord-341968-uc8i9h0m	243	24	[	[	-LRB-
cord-341968-uc8i9h0m	243	25	121	121	CD
cord-341968-uc8i9h0m	243	26	]	]	-RRB-
cord-341968-uc8i9h0m	243	27	[	[	-LRB-
cord-341968-uc8i9h0m	243	28	122	122	CD
cord-341968-uc8i9h0m	243	29	]	]	-RRB-
cord-341968-uc8i9h0m	243	30	;	;	:
cord-341968-uc8i9h0m	243	31	to	to	TO
cord-341968-uc8i9h0m	243	32	peptide	peptide	NN
cord-341968-uc8i9h0m	243	33	substrates	substrate	NNS
cord-341968-uc8i9h0m	243	34	[	[	-LRB-
cord-341968-uc8i9h0m	243	35	123	123	CD
cord-341968-uc8i9h0m	243	36	,	,	,
cord-341968-uc8i9h0m	243	37	124	124	CD
cord-341968-uc8i9h0m	243	38	]	]	-RRB-
cord-341968-uc8i9h0m	243	39	,	,	,
cord-341968-uc8i9h0m	243	40	or	or	CC
cord-341968-uc8i9h0m	243	41	viral	viral	JJ
cord-341968-uc8i9h0m	243	42	cleavage	cleavage	NN
cord-341968-uc8i9h0m	243	43	sites	site	NNS
cord-341968-uc8i9h0m	243	44	[	[	-LRB-
cord-341968-uc8i9h0m	243	45	125	125	CD
cord-341968-uc8i9h0m	243	46	]	]	-RRB-
cord-341968-uc8i9h0m	243	47	;	;	:
cord-341968-uc8i9h0m	244	1	peptide	peptide	JJ
cord-341968-uc8i9h0m	244	2	mimetic	mimetic	JJ
cord-341968-uc8i9h0m	244	3	derivatives	derivative	NNS
cord-341968-uc8i9h0m	244	4	that	that	WDT
cord-341968-uc8i9h0m	244	5	add	add	VBP
cord-341968-uc8i9h0m	244	6	unnatural	unnatural	JJ
cord-341968-uc8i9h0m	244	7	amino	amino	NN
cord-341968-uc8i9h0m	244	8	acids	acid	NNS
cord-341968-uc8i9h0m	244	9	[	[	-LRB-
cord-341968-uc8i9h0m	244	10	126	126	CD
cord-341968-uc8i9h0m	244	11	]	]	-RRB-
cord-341968-uc8i9h0m	244	12	[	[	-LRB-
cord-341968-uc8i9h0m	244	13	127	127	CD
cord-341968-uc8i9h0m	244	14	]	]	-RRB-
cord-341968-uc8i9h0m	244	15	[	[	-LRB-
cord-341968-uc8i9h0m	244	16	128	128	CD
cord-341968-uc8i9h0m	244	17	]	]	-RRB-
cord-341968-uc8i9h0m	244	18	[	[	-LRB-
cord-341968-uc8i9h0m	244	19	129	129	CD
cord-341968-uc8i9h0m	244	20	]	]	-RRB-
cord-341968-uc8i9h0m	244	21	[	[	-LRB-
cord-341968-uc8i9h0m	244	22	130	130	CD
cord-341968-uc8i9h0m	244	23	]	]	-RRB-
cord-341968-uc8i9h0m	244	24	[	[	-LRB-
cord-341968-uc8i9h0m	244	25	131	131	CD
cord-341968-uc8i9h0m	244	26	]	]	-RRB-
cord-341968-uc8i9h0m	244	27	[	[	-LRB-
cord-341968-uc8i9h0m	244	28	132	132	CD
cord-341968-uc8i9h0m	244	29	]	]	-RRB-
cord-341968-uc8i9h0m	244	30	[	[	-LRB-
cord-341968-uc8i9h0m	244	31	133	133	CD
cord-341968-uc8i9h0m	244	32	]	]	-RRB-
cord-341968-uc8i9h0m	244	33	[	[	-LRB-
cord-341968-uc8i9h0m	244	34	134	134	CD
cord-341968-uc8i9h0m	244	35	]	]	-RRB-
cord-341968-uc8i9h0m	244	36	[	[	-LRB-
cord-341968-uc8i9h0m	244	37	135	135	CD
cord-341968-uc8i9h0m	244	38	]	]	-RRB-
cord-341968-uc8i9h0m	244	39	;	;	:
cord-341968-uc8i9h0m	244	40	cyclic	cyclic	JJ
cord-341968-uc8i9h0m	244	41	peptides	peptide	NNS
cord-341968-uc8i9h0m	244	42	[	[	-LRB-
cord-341968-uc8i9h0m	244	43	136	136	CD
cord-341968-uc8i9h0m	244	44	]	]	-RRB-
cord-341968-uc8i9h0m	244	45	;	;	:
cord-341968-uc8i9h0m	244	46	polyarginine	polyarginine	NNP
cord-341968-uc8i9h0m	244	47	[	[	-LRB-
cord-341968-uc8i9h0m	244	48	137	137	CD
cord-341968-uc8i9h0m	244	49	]	]	-RRB-
cord-341968-uc8i9h0m	245	1	[	[	-LRB-
cord-341968-uc8i9h0m	245	2	138	138	CD
cord-341968-uc8i9h0m	245	3	]	]	-RRB-
cord-341968-uc8i9h0m	245	4	[	[	-LRB-
cord-341968-uc8i9h0m	245	5	139	139	CD
cord-341968-uc8i9h0m	245	6	]	]	-RRB-
cord-341968-uc8i9h0m	245	7	;	;	:
cord-341968-uc8i9h0m	245	8	and	and	CC
cord-341968-uc8i9h0m	245	9	larger	large	JJR
cord-341968-uc8i9h0m	245	10	engineered	engineer	VBN
cord-341968-uc8i9h0m	245	11	proteins	protein	NNS
cord-341968-uc8i9h0m	245	12	like	like	IN
cord-341968-uc8i9h0m	245	13	the	the	DT
cord-341968-uc8i9h0m	245	14	leech	leech	NN
cord-341968-uc8i9h0m	245	15	eglin	eglin	NNP
cord-341968-uc8i9h0m	245	16	C	C	NNP
cord-341968-uc8i9h0m	245	17	[	[	-LRB-
cord-341968-uc8i9h0m	245	18	140	140	CD
cord-341968-uc8i9h0m	245	19	]	]	-RRB-
cord-341968-uc8i9h0m	245	20	,	,	,
cord-341968-uc8i9h0m	245	21	turkey	turkey	NNP
cord-341968-uc8i9h0m	245	22	ovomucoid	ovomucoid	NNP
cord-341968-uc8i9h0m	245	23	[	[	-LRB-
cord-341968-uc8i9h0m	245	24	141	141	CD
cord-341968-uc8i9h0m	245	25	]	]	-RRB-
cord-341968-uc8i9h0m	245	26	,	,	,
cord-341968-uc8i9h0m	245	27	α2-macroglobulin	α2-macroglobulin	XX
cord-341968-uc8i9h0m	245	28	[	[	-LRB-
cord-341968-uc8i9h0m	245	29	142	142	CD
cord-341968-uc8i9h0m	245	30	]	]	-RRB-
cord-341968-uc8i9h0m	245	31	;	;	:
cord-341968-uc8i9h0m	245	32	and	and	CC
cord-341968-uc8i9h0m	245	33	the	the	DT
cord-341968-uc8i9h0m	245	34	engineered	engineer	VBN
cord-341968-uc8i9h0m	245	35	serpin	serpin	NN
cord-341968-uc8i9h0m	245	36	α1-PDX	α1-pdx	ADD
cord-341968-uc8i9h0m	245	37	[	[	-LRB-
cord-341968-uc8i9h0m	245	38	21	21	CD
cord-341968-uc8i9h0m	245	39	]	]	-RRB-
cord-341968-uc8i9h0m	245	40	.	.	.
cord-341968-uc8i9h0m	246	1	Peptide	peptide	NN
cord-341968-uc8i9h0m	246	2	derivatives	derivative	NNS
cord-341968-uc8i9h0m	246	3	seem	seem	VBP
cord-341968-uc8i9h0m	246	4	more	more	RBR
cord-341968-uc8i9h0m	246	5	efficient	efficient	JJ
cord-341968-uc8i9h0m	246	6	at	at	IN
cord-341968-uc8i9h0m	246	7	producing	produce	VBG
cord-341968-uc8i9h0m	246	8	high	high	JJ
cord-341968-uc8i9h0m	246	9	-	-	HYPH
cord-341968-uc8i9h0m	246	10	affinity	affinity	NN
cord-341968-uc8i9h0m	246	11	PC	pc	NN
cord-341968-uc8i9h0m	246	12	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	246	13	compared	compare	VBN
cord-341968-uc8i9h0m	246	14	to	to	IN
cord-341968-uc8i9h0m	246	15	small	small	JJ
cord-341968-uc8i9h0m	246	16	molecules	molecule	NNS
cord-341968-uc8i9h0m	246	17	[	[	-LRB-
cord-341968-uc8i9h0m	246	18	118	118	CD
cord-341968-uc8i9h0m	246	19	]	]	-RRB-
cord-341968-uc8i9h0m	246	20	.	.	.
cord-341968-uc8i9h0m	247	1	Due	due	IN
cord-341968-uc8i9h0m	247	2	to	to	IN
cord-341968-uc8i9h0m	247	3	the	the	DT
cord-341968-uc8i9h0m	247	4	high	high	JJ
cord-341968-uc8i9h0m	247	5	density	density	NN
cord-341968-uc8i9h0m	247	6	of	of	IN
cord-341968-uc8i9h0m	247	7	negative	negative	JJ
cord-341968-uc8i9h0m	247	8	charges	charge	NNS
cord-341968-uc8i9h0m	247	9	at	at	IN
cord-341968-uc8i9h0m	247	10	the	the	DT
cord-341968-uc8i9h0m	247	11	PC	pc	NN
cord-341968-uc8i9h0m	247	12	active	active	JJ
cord-341968-uc8i9h0m	247	13	site	site	NN
cord-341968-uc8i9h0m	247	14	,	,	,
cord-341968-uc8i9h0m	247	15	highly	highly	RB
cord-341968-uc8i9h0m	247	16	basic	basic	JJ
cord-341968-uc8i9h0m	247	17	peptides	peptide	NNS
cord-341968-uc8i9h0m	247	18	show	show	VBP
cord-341968-uc8i9h0m	247	19	strong	strong	JJ
cord-341968-uc8i9h0m	247	20	specificity	specificity	NN
cord-341968-uc8i9h0m	247	21	and	and	CC
cord-341968-uc8i9h0m	247	22	bioavailability	bioavailability	NN
cord-341968-uc8i9h0m	247	23	,	,	,
cord-341968-uc8i9h0m	247	24	but	but	CC
cord-341968-uc8i9h0m	247	25	may	may	MD
cord-341968-uc8i9h0m	247	26	also	also	RB
cord-341968-uc8i9h0m	247	27	be	be	VB
cord-341968-uc8i9h0m	247	28	highly	highly	RB
cord-341968-uc8i9h0m	247	29	toxic	toxic	JJ
cord-341968-uc8i9h0m	247	30	[	[	-LRB-
cord-341968-uc8i9h0m	247	31	133	133	CD
cord-341968-uc8i9h0m	247	32	]	]	-RRB-
cord-341968-uc8i9h0m	247	33	.	.	.
cord-341968-uc8i9h0m	248	1	Larger	large	JJR
cord-341968-uc8i9h0m	248	2	proteins	protein	NNS
cord-341968-uc8i9h0m	248	3	are	be	VBP
cord-341968-uc8i9h0m	248	4	poised	poise	VBN
cord-341968-uc8i9h0m	248	5	to	to	TO
cord-341968-uc8i9h0m	248	6	become	become	VB
cord-341968-uc8i9h0m	248	7	the	the	DT
cord-341968-uc8i9h0m	248	8	most	most	RBS
cord-341968-uc8i9h0m	248	9	effective	effective	JJ
cord-341968-uc8i9h0m	248	10	PC	pc	NN
cord-341968-uc8i9h0m	248	11	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	248	12	as	as	IN
cord-341968-uc8i9h0m	248	13	they	-PRON-	PRP
cord-341968-uc8i9h0m	248	14	offer	offer	VBP
cord-341968-uc8i9h0m	248	15	better	well	JJR
cord-341968-uc8i9h0m	248	16	opportunities	opportunity	NNS
cord-341968-uc8i9h0m	248	17	to	to	TO
cord-341968-uc8i9h0m	248	18	build	build	VB
cord-341968-uc8i9h0m	248	19	specificity	specificity	NN
cord-341968-uc8i9h0m	248	20	and	and	CC
cord-341968-uc8i9h0m	248	21	selectivity	selectivity	NN
cord-341968-uc8i9h0m	248	22	compared	compare	VBN
cord-341968-uc8i9h0m	248	23	to	to	IN
cord-341968-uc8i9h0m	248	24	small	small	JJ
cord-341968-uc8i9h0m	248	25	molecules	molecule	NNS
cord-341968-uc8i9h0m	248	26	.	.	.
cord-341968-uc8i9h0m	249	1	They	-PRON-	PRP
cord-341968-uc8i9h0m	249	2	can	can	MD
cord-341968-uc8i9h0m	249	3	also	also	RB
cord-341968-uc8i9h0m	249	4	be	be	VB
cord-341968-uc8i9h0m	249	5	made	make	VBN
cord-341968-uc8i9h0m	249	6	bioavailable	bioavailable	JJ
cord-341968-uc8i9h0m	249	7	through	through	IN
cord-341968-uc8i9h0m	249	8	a	a	DT
cord-341968-uc8i9h0m	249	9	variety	variety	NN
cord-341968-uc8i9h0m	249	10	of	of	IN
cord-341968-uc8i9h0m	249	11	routes	route	NNS
cord-341968-uc8i9h0m	249	12	.	.	.
cord-341968-uc8i9h0m	250	1	Several	several	JJ
cord-341968-uc8i9h0m	250	2	of	of	IN
cord-341968-uc8i9h0m	250	3	these	these	DT
cord-341968-uc8i9h0m	250	4	PC	pc	NN
cord-341968-uc8i9h0m	250	5	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	250	6	have	have	VBP
cord-341968-uc8i9h0m	250	7	been	be	VBN
cord-341968-uc8i9h0m	250	8	confirmed	confirm	VBN
cord-341968-uc8i9h0m	250	9	to	to	TO
cord-341968-uc8i9h0m	250	10	have	have	VB
cord-341968-uc8i9h0m	250	11	antiviral	antiviral	JJ
cord-341968-uc8i9h0m	250	12	activity	activity	NN
cord-341968-uc8i9h0m	250	13	in	in	IN
cord-341968-uc8i9h0m	250	14	cell	cell	NN
cord-341968-uc8i9h0m	250	15	-	-	HYPH
cord-341968-uc8i9h0m	250	16	based	base	VBN
cord-341968-uc8i9h0m	250	17	assays	assay	NNS
cord-341968-uc8i9h0m	250	18	of	of	IN
cord-341968-uc8i9h0m	250	19	viral	viral	JJ
cord-341968-uc8i9h0m	250	20	propagation	propagation	NN
cord-341968-uc8i9h0m	250	21	(	(	-LRB-
cord-341968-uc8i9h0m	250	22	Table	Table	NNP
cord-341968-uc8i9h0m	250	23	6	6	CD
cord-341968-uc8i9h0m	250	24	)	)	-RRB-
cord-341968-uc8i9h0m	250	25	.	.	.
cord-341968-uc8i9h0m	251	1	Table	table	NN
cord-341968-uc8i9h0m	251	2	6	6	CD
cord-341968-uc8i9h0m	251	3	.	.	.
cord-341968-uc8i9h0m	252	1	Inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	252	2	of	of	IN
cord-341968-uc8i9h0m	252	3	PCs	pc	NNS
cord-341968-uc8i9h0m	252	4	tested	test	VBN
cord-341968-uc8i9h0m	252	5	for	for	IN
cord-341968-uc8i9h0m	252	6	their	-PRON-	PRP$
cord-341968-uc8i9h0m	252	7	antiviral	antiviral	JJ
cord-341968-uc8i9h0m	252	8	activity	activity	NN
cord-341968-uc8i9h0m	252	9	in	in	IN
cord-341968-uc8i9h0m	252	10	cell	cell	NN
cord-341968-uc8i9h0m	252	11	-	-	HYPH
cord-341968-uc8i9h0m	252	12	based	base	VBN
cord-341968-uc8i9h0m	252	13	assays	assay	NNS
cord-341968-uc8i9h0m	252	14	of	of	IN
cord-341968-uc8i9h0m	252	15	viral	viral	JJ
cord-341968-uc8i9h0m	252	16	propagation	propagation	NN
cord-341968-uc8i9h0m	252	17	.	.	.
cord-341968-uc8i9h0m	253	1	SKI-1	SKI-1	NNP
cord-341968-uc8i9h0m	253	2	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	253	3	LCMV	LCMV	NNP
cord-341968-uc8i9h0m	253	4	,	,	,
cord-341968-uc8i9h0m	254	1	LASV	LASV	NNP
cord-341968-uc8i9h0m	254	2	[	[	-LRB-
cord-341968-uc8i9h0m	254	3	89	89	CD
cord-341968-uc8i9h0m	254	4	,	,	,
cord-341968-uc8i9h0m	254	5	90	90	CD
cord-341968-uc8i9h0m	254	6	]	]	-RRB-
cord-341968-uc8i9h0m	254	7	Peptides	peptide	NNS
cord-341968-uc8i9h0m	254	8	and	and	CC
cord-341968-uc8i9h0m	254	9	peptidomimetics	peptidomimetic	NNS
cord-341968-uc8i9h0m	254	10	CHIKV	CHIKV	NNP
cord-341968-uc8i9h0m	254	11	,	,	,
cord-341968-uc8i9h0m	254	12	SFV	SFV	NNP
cord-341968-uc8i9h0m	254	13	WNV	WNV	NNP
cord-341968-uc8i9h0m	254	14	,	,	,
cord-341968-uc8i9h0m	254	15	DENV	DENV	NNP
cord-341968-uc8i9h0m	254	16	H5	H5	NNP
cord-341968-uc8i9h0m	254	17	and	and	CC
cord-341968-uc8i9h0m	254	18	H7	H7	NNP
cord-341968-uc8i9h0m	254	19	influenza	influenza	NN
cord-341968-uc8i9h0m	254	20	[	[	-LRB-
cord-341968-uc8i9h0m	254	21	52	52	CD
cord-341968-uc8i9h0m	254	22	,	,	,
cord-341968-uc8i9h0m	254	23	134	134	CD
cord-341968-uc8i9h0m	254	24	]	]	-RRB-
cord-341968-uc8i9h0m	254	25	 	 	_SP
cord-341968-uc8i9h0m	255	1	The	the	DT
cord-341968-uc8i9h0m	255	2	ubiquitous	ubiquitous	JJ
cord-341968-uc8i9h0m	255	3	presence	presence	NN
cord-341968-uc8i9h0m	255	4	of	of	IN
cord-341968-uc8i9h0m	255	5	furin	furin	NN
cord-341968-uc8i9h0m	255	6	and	and	CC
cord-341968-uc8i9h0m	255	7	related	related	JJ
cord-341968-uc8i9h0m	255	8	PCs	pc	NNS
cord-341968-uc8i9h0m	255	9	throughout	throughout	IN
cord-341968-uc8i9h0m	255	10	the	the	DT
cord-341968-uc8i9h0m	255	11	cells	cell	NNS
cord-341968-uc8i9h0m	255	12	of	of	IN
cord-341968-uc8i9h0m	255	13	the	the	DT
cord-341968-uc8i9h0m	255	14	body	body	NN
cord-341968-uc8i9h0m	255	15	makes	make	VBZ
cord-341968-uc8i9h0m	255	16	these	these	DT
cord-341968-uc8i9h0m	255	17	proteases	protease	NNS
cord-341968-uc8i9h0m	255	18	vulnerable	vulnerable	JJ
cord-341968-uc8i9h0m	255	19	to	to	IN
cord-341968-uc8i9h0m	255	20	being	be	VBG
cord-341968-uc8i9h0m	255	21	exploited	exploit	VBN
cord-341968-uc8i9h0m	255	22	by	by	IN
cord-341968-uc8i9h0m	255	23	viruses	virus	NNS
cord-341968-uc8i9h0m	255	24	.	.	.
cord-341968-uc8i9h0m	256	1	The	the	DT
cord-341968-uc8i9h0m	256	2	location	location	NN
cord-341968-uc8i9h0m	256	3	of	of	IN
cord-341968-uc8i9h0m	256	4	furin	furin	NN
cord-341968-uc8i9h0m	256	5	and	and	CC
cord-341968-uc8i9h0m	256	6	related	related	JJ
cord-341968-uc8i9h0m	256	7	PCs	pc	NNS
cord-341968-uc8i9h0m	256	8	in	in	IN
cord-341968-uc8i9h0m	256	9	the	the	DT
cord-341968-uc8i9h0m	256	10	vesicles	vesicle	NNS
cord-341968-uc8i9h0m	256	11	of	of	IN
cord-341968-uc8i9h0m	256	12	the	the	DT
cord-341968-uc8i9h0m	256	13	constitutive	constitutive	JJ
cord-341968-uc8i9h0m	256	14	protein	protein	NN
cord-341968-uc8i9h0m	256	15	secretion	secretion	NN
cord-341968-uc8i9h0m	256	16	pathway	pathway	NN
cord-341968-uc8i9h0m	256	17	,	,	,
cord-341968-uc8i9h0m	256	18	where	where	WRB
cord-341968-uc8i9h0m	256	19	viruses	virus	NNS
cord-341968-uc8i9h0m	256	20	are	be	VBP
cord-341968-uc8i9h0m	256	21	assembled	assemble	VBN
cord-341968-uc8i9h0m	256	22	during	during	IN
cord-341968-uc8i9h0m	256	23	morphogenesis	morphogenesis	NN
cord-341968-uc8i9h0m	256	24	or	or	CC
cord-341968-uc8i9h0m	256	25	disassembled	disassemble	VBN
cord-341968-uc8i9h0m	256	26	during	during	IN
cord-341968-uc8i9h0m	256	27	cell	cell	NN
cord-341968-uc8i9h0m	256	28	entry	entry	NN
cord-341968-uc8i9h0m	256	29	,	,	,
cord-341968-uc8i9h0m	256	30	explains	explain	VBZ
cord-341968-uc8i9h0m	256	31	why	why	WRB
cord-341968-uc8i9h0m	256	32	a	a	DT
cord-341968-uc8i9h0m	256	33	diversity	diversity	NN
cord-341968-uc8i9h0m	256	34	of	of	IN
cord-341968-uc8i9h0m	256	35	virus	virus	NN
cord-341968-uc8i9h0m	256	36	types	type	NNS
cord-341968-uc8i9h0m	256	37	have	have	VBP
cord-341968-uc8i9h0m	256	38	evolutionarily	evolutionarily	RB
cord-341968-uc8i9h0m	256	39	converged	converge	VBN
cord-341968-uc8i9h0m	256	40	to	to	TO
cord-341968-uc8i9h0m	256	41	depend	depend	VB
cord-341968-uc8i9h0m	256	42	on	on	IN
cord-341968-uc8i9h0m	256	43	PCs	pc	NNS
cord-341968-uc8i9h0m	256	44	.	.	.
cord-341968-uc8i9h0m	257	1	Viruses	virus	NNS
cord-341968-uc8i9h0m	257	2	also	also	RB
cord-341968-uc8i9h0m	257	3	use	use	VBP
cord-341968-uc8i9h0m	257	4	other	other	JJ
cord-341968-uc8i9h0m	257	5	types	type	NNS
cord-341968-uc8i9h0m	257	6	of	of	IN
cord-341968-uc8i9h0m	257	7	proteases	protease	NNS
cord-341968-uc8i9h0m	257	8	for	for	IN
cord-341968-uc8i9h0m	257	9	the	the	DT
cord-341968-uc8i9h0m	257	10	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	257	11	regulation	regulation	NN
cord-341968-uc8i9h0m	257	12	of	of	IN
cord-341968-uc8i9h0m	257	13	the	the	DT
cord-341968-uc8i9h0m	257	14	binding	binding	NN
cord-341968-uc8i9h0m	257	15	and	and	CC
cord-341968-uc8i9h0m	257	16	fusion	fusion	NN
cord-341968-uc8i9h0m	257	17	functions	function	NNS
cord-341968-uc8i9h0m	257	18	;	;	:
cord-341968-uc8i9h0m	257	19	however	however	RB
cord-341968-uc8i9h0m	257	20	,	,	,
cord-341968-uc8i9h0m	257	21	proteases	protease	NNS
cord-341968-uc8i9h0m	257	22	are	be	VBP
cord-341968-uc8i9h0m	257	23	restricted	restrict	VBN
cord-341968-uc8i9h0m	257	24	to	to	IN
cord-341968-uc8i9h0m	257	25	specific	specific	JJ
cord-341968-uc8i9h0m	257	26	cell	cell	NN
cord-341968-uc8i9h0m	257	27	types	type	NNS
cord-341968-uc8i9h0m	257	28	,	,	,
cord-341968-uc8i9h0m	257	29	which	which	WDT
cord-341968-uc8i9h0m	257	30	limits	limit	VBZ
cord-341968-uc8i9h0m	257	31	the	the	DT
cord-341968-uc8i9h0m	257	32	range	range	NN
cord-341968-uc8i9h0m	257	33	of	of	IN
cord-341968-uc8i9h0m	257	34	the	the	DT
cord-341968-uc8i9h0m	257	35	viral	viral	JJ
cord-341968-uc8i9h0m	257	36	infection	infection	NN
cord-341968-uc8i9h0m	257	37	,	,	,
cord-341968-uc8i9h0m	257	38	so	so	CC
cord-341968-uc8i9h0m	257	39	when	when	WRB
cord-341968-uc8i9h0m	257	40	some	some	DT
cord-341968-uc8i9h0m	257	41	viruses	virus	NNS
cord-341968-uc8i9h0m	257	42	mutate	mutate	VBP
cord-341968-uc8i9h0m	257	43	and	and	CC
cord-341968-uc8i9h0m	257	44	acquire	acquire	VBP
cord-341968-uc8i9h0m	257	45	PC	pc	NN
cord-341968-uc8i9h0m	257	46	reactivity	reactivity	NN
cord-341968-uc8i9h0m	257	47	,	,	,
cord-341968-uc8i9h0m	257	48	they	-PRON-	PRP
cord-341968-uc8i9h0m	257	49	may	may	MD
cord-341968-uc8i9h0m	257	50	expand	expand	VB
cord-341968-uc8i9h0m	257	51	their	-PRON-	PRP$
cord-341968-uc8i9h0m	257	52	cell	cell	NN
cord-341968-uc8i9h0m	257	53	tropism	tropism	NN
cord-341968-uc8i9h0m	257	54	and	and	CC
cord-341968-uc8i9h0m	257	55	become	become	VB
cord-341968-uc8i9h0m	257	56	more	more	RBR
cord-341968-uc8i9h0m	257	57	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	257	58	.	.	.
cord-341968-uc8i9h0m	258	1	The	the	DT
cord-341968-uc8i9h0m	258	2	targeting	targeting	NN
cord-341968-uc8i9h0m	258	3	of	of	IN
cord-341968-uc8i9h0m	258	4	PCs	pc	NNS
cord-341968-uc8i9h0m	258	5	for	for	IN
cord-341968-uc8i9h0m	258	6	inhibition	inhibition	NN
cord-341968-uc8i9h0m	258	7	as	as	IN
cord-341968-uc8i9h0m	258	8	an	an	DT
cord-341968-uc8i9h0m	258	9	antiviral	antiviral	JJ
cord-341968-uc8i9h0m	258	10	strategy	strategy	NN
cord-341968-uc8i9h0m	258	11	is	be	VBZ
cord-341968-uc8i9h0m	258	12	a	a	DT
cord-341968-uc8i9h0m	258	13	sound	sound	JJ
cord-341968-uc8i9h0m	258	14	possibility	possibility	NN
cord-341968-uc8i9h0m	258	15	.	.	.
cord-341968-uc8i9h0m	259	1	Probably	probably	RB
cord-341968-uc8i9h0m	259	2	the	the	DT
cord-341968-uc8i9h0m	259	3	major	major	JJ
cord-341968-uc8i9h0m	259	4	advantage	advantage	NN
cord-341968-uc8i9h0m	259	5	of	of	IN
cord-341968-uc8i9h0m	259	6	this	this	DT
cord-341968-uc8i9h0m	259	7	approach	approach	NN
cord-341968-uc8i9h0m	259	8	is	be	VBZ
cord-341968-uc8i9h0m	259	9	that	that	IN
cord-341968-uc8i9h0m	259	10	by	by	IN
cord-341968-uc8i9h0m	259	11	not	not	RB
cord-341968-uc8i9h0m	259	12	targeting	target	VBG
cord-341968-uc8i9h0m	259	13	a	a	DT
cord-341968-uc8i9h0m	259	14	viral	viral	JJ
cord-341968-uc8i9h0m	259	15	component	component	NN
cord-341968-uc8i9h0m	259	16	or	or	CC
cord-341968-uc8i9h0m	259	17	function	function	NN
cord-341968-uc8i9h0m	259	18	,	,	,
cord-341968-uc8i9h0m	259	19	it	-PRON-	PRP
cord-341968-uc8i9h0m	259	20	reduces	reduce	VBZ
cord-341968-uc8i9h0m	259	21	the	the	DT
cord-341968-uc8i9h0m	259	22	chance	chance	NN
cord-341968-uc8i9h0m	259	23	of	of	IN
cord-341968-uc8i9h0m	259	24	producing	produce	VBG
cord-341968-uc8i9h0m	259	25	resistance	resistance	NN
cord-341968-uc8i9h0m	259	26	.	.	.
cord-341968-uc8i9h0m	260	1	The	the	DT
cord-341968-uc8i9h0m	260	2	main	main	JJ
cord-341968-uc8i9h0m	260	3	drawback	drawback	NN
cord-341968-uc8i9h0m	260	4	is	be	VBZ
cord-341968-uc8i9h0m	260	5	the	the	DT
cord-341968-uc8i9h0m	260	6	ubiquitous	ubiquitous	JJ
cord-341968-uc8i9h0m	260	7	distribution	distribution	NN
cord-341968-uc8i9h0m	260	8	of	of	IN
cord-341968-uc8i9h0m	260	9	PCs	pc	NNS
cord-341968-uc8i9h0m	260	10	and	and	CC
cord-341968-uc8i9h0m	260	11	the	the	DT
cord-341968-uc8i9h0m	260	12	potential	potential	JJ
cord-341968-uc8i9h0m	260	13	toxicity	toxicity	NN
cord-341968-uc8i9h0m	260	14	and	and	CC
cord-341968-uc8i9h0m	260	15	secondary	secondary	JJ
cord-341968-uc8i9h0m	260	16	effects	effect	NNS
cord-341968-uc8i9h0m	260	17	that	that	WDT
cord-341968-uc8i9h0m	260	18	their	-PRON-	PRP$
cord-341968-uc8i9h0m	260	19	inhibition	inhibition	NN
cord-341968-uc8i9h0m	260	20	may	may	MD
cord-341968-uc8i9h0m	260	21	cause	cause	VB
cord-341968-uc8i9h0m	260	22	.	.	.
cord-341968-uc8i9h0m	261	1	In	in	IN
cord-341968-uc8i9h0m	261	2	consequence	consequence	NN
cord-341968-uc8i9h0m	261	3	,	,	,
cord-341968-uc8i9h0m	261	4	it	-PRON-	PRP
cord-341968-uc8i9h0m	261	5	is	be	VBZ
cord-341968-uc8i9h0m	261	6	essential	essential	JJ
cord-341968-uc8i9h0m	261	7	to	to	TO
cord-341968-uc8i9h0m	261	8	know	know	VB
cord-341968-uc8i9h0m	261	9	the	the	DT
cord-341968-uc8i9h0m	261	10	virus	virus	NN
cord-341968-uc8i9h0m	261	11	PC	pc	NN
cord-341968-uc8i9h0m	261	12	selectivity	selectivity	NN
cord-341968-uc8i9h0m	261	13	and	and	CC
cord-341968-uc8i9h0m	261	14	to	to	TO
cord-341968-uc8i9h0m	261	15	have	have	VB
cord-341968-uc8i9h0m	261	16	PC	pc	NN
cord-341968-uc8i9h0m	261	17	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	261	18	that	that	WDT
cord-341968-uc8i9h0m	261	19	are	be	VBP
cord-341968-uc8i9h0m	261	20	selective	selective	JJ
cord-341968-uc8i9h0m	261	21	for	for	IN
cord-341968-uc8i9h0m	261	22	one	one	CD
cord-341968-uc8i9h0m	261	23	of	of	IN
cord-341968-uc8i9h0m	261	24	the	the	DT
cord-341968-uc8i9h0m	261	25	two	two	CD
cord-341968-uc8i9h0m	261	26	PC	pc	NN
cord-341968-uc8i9h0m	261	27	specificity	specificity	NN
cord-341968-uc8i9h0m	261	28	groups	group	NNS
cord-341968-uc8i9h0m	261	29	,	,	,
cord-341968-uc8i9h0m	261	30	furin	furin	NN
cord-341968-uc8i9h0m	261	31	or	or	CC
cord-341968-uc8i9h0m	261	32	PC4	pc4	NN
cord-341968-uc8i9h0m	261	33	/	/	SYM
cord-341968-uc8i9h0m	261	34	PC5	PC5	NNP
cord-341968-uc8i9h0m	261	35	/	/	SYM
cord-341968-uc8i9h0m	261	36	PACE4	PACE4	NNP
cord-341968-uc8i9h0m	262	1	/PC7	/PC7	:
cord-341968-uc8i9h0m	262	2	[	[	-LRB-
cord-341968-uc8i9h0m	262	3	9	9	CD
cord-341968-uc8i9h0m	262	4	]	]	-RRB-
cord-341968-uc8i9h0m	262	5	.	.	.
cord-341968-uc8i9h0m	263	1	Funding	funding	NN
cord-341968-uc8i9h0m	263	2	:	:	:
cord-341968-uc8i9h0m	264	1	This	this	DT
cord-341968-uc8i9h0m	264	2	research	research	NN
cord-341968-uc8i9h0m	264	3	received	receive	VBD
cord-341968-uc8i9h0m	264	4	no	no	DT
cord-341968-uc8i9h0m	264	5	external	external	JJ
cord-341968-uc8i9h0m	264	6	funding	funding	NN
cord-341968-uc8i9h0m	264	7	.	.	.
cord-341968-uc8i9h0m	265	1	The	the	DT
cord-341968-uc8i9h0m	265	2	author	author	NN
cord-341968-uc8i9h0m	265	3	declares	declare	VBZ
cord-341968-uc8i9h0m	265	4	no	no	DT
cord-341968-uc8i9h0m	265	5	conflict	conflict	NN
cord-341968-uc8i9h0m	265	6	of	of	IN
cord-341968-uc8i9h0m	265	7	interest	interest	NN
cord-341968-uc8i9h0m	265	8	.	.	.
cord-341968-uc8i9h0m	266	1	The	the	DT
cord-341968-uc8i9h0m	266	2	activation	activation	NN
cord-341968-uc8i9h0m	266	3	and	and	CC
cord-341968-uc8i9h0m	266	4	physiological	physiological	JJ
cord-341968-uc8i9h0m	266	5	functions	function	NNS
cord-341968-uc8i9h0m	266	6	of	of	IN
cord-341968-uc8i9h0m	266	7	the	the	DT
cord-341968-uc8i9h0m	266	8	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	266	9	convertases	convertases	NNP
cord-341968-uc8i9h0m	267	1	The	the	DT
cord-341968-uc8i9h0m	267	2	biology	biology	NN
cord-341968-uc8i9h0m	267	3	and	and	CC
cord-341968-uc8i9h0m	267	4	therapeutic	therapeutic	JJ
cord-341968-uc8i9h0m	267	5	targeting	targeting	NN
cord-341968-uc8i9h0m	267	6	of	of	IN
cord-341968-uc8i9h0m	267	7	the	the	DT
cord-341968-uc8i9h0m	267	8	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	267	9	convertases	convertases	NNP
cord-341968-uc8i9h0m	267	10	Implication	Implication	NNP
cord-341968-uc8i9h0m	267	11	of	of	IN
cord-341968-uc8i9h0m	267	12	the	the	DT
cord-341968-uc8i9h0m	267	13	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	268	1	convertases	convertases	NNP
cord-341968-uc8i9h0m	268	2	furin	furin	NNP
cord-341968-uc8i9h0m	268	3	,	,	,
cord-341968-uc8i9h0m	268	4	PC5	pc5	NN
cord-341968-uc8i9h0m	268	5	and	and	CC
cord-341968-uc8i9h0m	268	6	PC7	PC7	NNS
cord-341968-uc8i9h0m	268	7	in	in	IN
cord-341968-uc8i9h0m	268	8	the	the	DT
cord-341968-uc8i9h0m	268	9	cleavage	cleavage	NN
cord-341968-uc8i9h0m	268	10	of	of	IN
cord-341968-uc8i9h0m	268	11	surface	surface	NN
cord-341968-uc8i9h0m	268	12	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	268	13	of	of	IN
cord-341968-uc8i9h0m	268	14	Hong	Hong	NNP
cord-341968-uc8i9h0m	268	15	Kong	Kong	NNP
cord-341968-uc8i9h0m	268	16	,	,	,
cord-341968-uc8i9h0m	268	17	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	268	18	and	and	CC
cord-341968-uc8i9h0m	268	19	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	268	20	syncytial	syncytial	JJ
cord-341968-uc8i9h0m	268	21	viruses	virus	NNS
cord-341968-uc8i9h0m	268	22	:	:	:
cord-341968-uc8i9h0m	269	1	A	a	DT
cord-341968-uc8i9h0m	269	2	comparative	comparative	JJ
cord-341968-uc8i9h0m	269	3	analysis	analysis	NN
cord-341968-uc8i9h0m	269	4	with	with	IN
cord-341968-uc8i9h0m	269	5	fluorogenic	fluorogenic	NNP
cord-341968-uc8i9h0m	269	6	peptides	peptide	NNS
cord-341968-uc8i9h0m	270	1	Proprotein	Proprotein	NNP
cord-341968-uc8i9h0m	270	2	convertases	convertase	VBZ
cord-341968-uc8i9h0m	270	3	in	in	IN
cord-341968-uc8i9h0m	270	4	health	health	NN
cord-341968-uc8i9h0m	270	5	and	and	CC
cord-341968-uc8i9h0m	270	6	disease	disease	NN
cord-341968-uc8i9h0m	270	7	On	on	IN
cord-341968-uc8i9h0m	270	8	the	the	DT
cord-341968-uc8i9h0m	270	9	cutting	cutting	JJ
cord-341968-uc8i9h0m	270	10	edge	edge	NN
cord-341968-uc8i9h0m	270	11	of	of	IN
cord-341968-uc8i9h0m	270	12	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	270	13	convertase	convertase	NNP
cord-341968-uc8i9h0m	270	14	pharmacology	pharmacology	NNP
cord-341968-uc8i9h0m	270	15	:	:	:
cord-341968-uc8i9h0m	271	1	From	from	IN
cord-341968-uc8i9h0m	271	2	molecular	molecular	JJ
cord-341968-uc8i9h0m	271	3	concepts	concept	NNS
cord-341968-uc8i9h0m	271	4	to	to	IN
cord-341968-uc8i9h0m	271	5	clinical	clinical	JJ
cord-341968-uc8i9h0m	271	6	applications	application	NNS
cord-341968-uc8i9h0m	271	7	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	271	8	virus	virus	NN
cord-341968-uc8i9h0m	271	9	envelope	envelope	NN
cord-341968-uc8i9h0m	271	10	grycoprotein	grycoprotein	NNP
cord-341968-uc8i9h0m	271	11	derived	derive	VBD
cord-341968-uc8i9h0m	271	12	peptide	peptide	NN
cord-341968-uc8i9h0m	271	13	in	in	IN
cord-341968-uc8i9h0m	271	14	human	human	JJ
cord-341968-uc8i9h0m	271	15	furin	furin	NN
cord-341968-uc8i9h0m	271	16	-	-	HYPH
cord-341968-uc8i9h0m	271	17	bound	bind	VBN
cord-341968-uc8i9h0m	271	18	state	state	NN
cord-341968-uc8i9h0m	271	19	:	:	:
cord-341968-uc8i9h0m	272	1	Computational	computational	JJ
cord-341968-uc8i9h0m	272	2	studies	study	NNS
cord-341968-uc8i9h0m	272	3	Structure	Structure	NNP
cord-341968-uc8i9h0m	272	4	of	of	IN
cord-341968-uc8i9h0m	272	5	the	the	DT
cord-341968-uc8i9h0m	272	6	unliganded	unligande	VBN
cord-341968-uc8i9h0m	272	7	form	form	NN
cord-341968-uc8i9h0m	272	8	of	of	IN
cord-341968-uc8i9h0m	272	9	the	the	DT
cord-341968-uc8i9h0m	272	10	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	272	11	convertase	convertase	NNP
cord-341968-uc8i9h0m	272	12	furin	furin	NNP
cord-341968-uc8i9h0m	272	13	suggests	suggest	VBZ
cord-341968-uc8i9h0m	272	14	activation	activation	NN
cord-341968-uc8i9h0m	272	15	by	by	IN
cord-341968-uc8i9h0m	272	16	a	a	DT
cord-341968-uc8i9h0m	272	17	substrate	substrate	NN
cord-341968-uc8i9h0m	272	18	-	-	HYPH
cord-341968-uc8i9h0m	272	19	induced	induce	VBN
cord-341968-uc8i9h0m	272	20	mechanism	mechanism	NN
cord-341968-uc8i9h0m	272	21	Identification	identification	NN
cord-341968-uc8i9h0m	272	22	of	of	IN
cord-341968-uc8i9h0m	272	23	serpin	serpin	JJ
cord-341968-uc8i9h0m	272	24	determinants	determinant	NNS
cord-341968-uc8i9h0m	272	25	of	of	IN
cord-341968-uc8i9h0m	272	26	specificity	specificity	NN
cord-341968-uc8i9h0m	272	27	and	and	CC
cord-341968-uc8i9h0m	272	28	selectivity	selectivity	NN
cord-341968-uc8i9h0m	272	29	for	for	IN
cord-341968-uc8i9h0m	272	30	furin	furin	NN
cord-341968-uc8i9h0m	272	31	inhibition	inhibition	NN
cord-341968-uc8i9h0m	272	32	through	through	IN
cord-341968-uc8i9h0m	272	33	studies	study	NNS
cord-341968-uc8i9h0m	272	34	of	of	IN
cord-341968-uc8i9h0m	272	35	α1-PDX	α1-PDX	NNP
cord-341968-uc8i9h0m	273	1	(	(	-LRB-
cord-341968-uc8i9h0m	273	2	α1-proteinase	α1-proteinase	DT
cord-341968-uc8i9h0m	273	3	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	273	4	Portland)-serpin	portland)-serpin	NN
cord-341968-uc8i9h0m	273	5	B8	b8	NN
cord-341968-uc8i9h0m	273	6	and	and	CC
cord-341968-uc8i9h0m	273	7	furin	furin	NN
cord-341968-uc8i9h0m	273	8	active	active	JJ
cord-341968-uc8i9h0m	273	9	-	-	HYPH
cord-341968-uc8i9h0m	273	10	site	site	NN
cord-341968-uc8i9h0m	273	11	loop	loop	NN
cord-341968-uc8i9h0m	273	12	chimeras	chimera	NNS
cord-341968-uc8i9h0m	274	1	Specific	specific	JJ
cord-341968-uc8i9h0m	274	2	and	and	CC
cord-341968-uc8i9h0m	274	3	selective	selective	JJ
cord-341968-uc8i9h0m	274	4	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	274	5	of	of	IN
cord-341968-uc8i9h0m	274	6	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	274	7	convertases	convertases	NNP
cord-341968-uc8i9h0m	274	8	engineered	engineer	VBN
cord-341968-uc8i9h0m	274	9	by	by	IN
cord-341968-uc8i9h0m	274	10	transferring	transfer	VBG
cord-341968-uc8i9h0m	274	11	serpin	serpin	NNP
cord-341968-uc8i9h0m	274	12	B8	B8	NNP
cord-341968-uc8i9h0m	274	13	reactive	reactive	JJ
cord-341968-uc8i9h0m	274	14	-	-	HYPH
cord-341968-uc8i9h0m	274	15	site	site	NN
cord-341968-uc8i9h0m	274	16	and	and	CC
cord-341968-uc8i9h0m	274	17	exosite	exosite	JJ
cord-341968-uc8i9h0m	274	18	determinants	determinant	NNS
cord-341968-uc8i9h0m	274	19	of	of	IN
cord-341968-uc8i9h0m	274	20	reactivity	reactivity	NN
cord-341968-uc8i9h0m	274	21	to	to	IN
cord-341968-uc8i9h0m	274	22	the	the	DT
cord-341968-uc8i9h0m	274	23	serpin	serpin	NN
cord-341968-uc8i9h0m	274	24	α1PDX	α1PDX	NNP
cord-341968-uc8i9h0m	274	25	Processing	processing	NN
cord-341968-uc8i9h0m	274	26	of	of	IN
cord-341968-uc8i9h0m	274	27	viral	viral	JJ
cord-341968-uc8i9h0m	274	28	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	274	29	by	by	IN
cord-341968-uc8i9h0m	274	30	the	the	DT
cord-341968-uc8i9h0m	274	31	subtilisin	subtilisin	NNP
cord-341968-uc8i9h0m	274	32	-	-	HYPH
cord-341968-uc8i9h0m	274	33	like	like	JJ
cord-341968-uc8i9h0m	274	34	endoprotease	endoprotease	NN
cord-341968-uc8i9h0m	274	35	furin	furin	NN
cord-341968-uc8i9h0m	274	36	and	and	CC
cord-341968-uc8i9h0m	274	37	its	-PRON-	PRP$
cord-341968-uc8i9h0m	274	38	inhibition	inhibition	NN
cord-341968-uc8i9h0m	274	39	by	by	IN
cord-341968-uc8i9h0m	274	40	specific	specific	JJ
cord-341968-uc8i9h0m	274	41	peptidylchloroalkylketones	peptidylchloroalkylketone	NNS
cord-341968-uc8i9h0m	274	42	Substrate	Substrate	NNP
cord-341968-uc8i9h0m	274	43	cleavage	cleavage	NN
cord-341968-uc8i9h0m	274	44	analysis	analysis	NN
cord-341968-uc8i9h0m	274	45	of	of	IN
cord-341968-uc8i9h0m	274	46	furin	furin	NN
cord-341968-uc8i9h0m	274	47	and	and	CC
cord-341968-uc8i9h0m	274	48	related	relate	VBN
cord-341968-uc8i9h0m	274	49	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	274	50	convertases	convertases	NNP
cord-341968-uc8i9h0m	274	51	.	.	.
cord-341968-uc8i9h0m	275	1	A	a	DT
cord-341968-uc8i9h0m	275	2	comparative	comparative	JJ
cord-341968-uc8i9h0m	275	3	study	study	NN
cord-341968-uc8i9h0m	275	4	High	high	JJ
cord-341968-uc8i9h0m	275	5	-	-	HYPH
cord-341968-uc8i9h0m	275	6	resolution	resolution	NN
cord-341968-uc8i9h0m	275	7	analysis	analysis	NN
cord-341968-uc8i9h0m	275	8	and	and	CC
cord-341968-uc8i9h0m	275	9	functional	functional	JJ
cord-341968-uc8i9h0m	275	10	mapping	mapping	NN
cord-341968-uc8i9h0m	275	11	of	of	IN
cord-341968-uc8i9h0m	275	12	cleavage	cleavage	NN
cord-341968-uc8i9h0m	275	13	sites	site	NNS
cord-341968-uc8i9h0m	275	14	and	and	CC
cord-341968-uc8i9h0m	275	15	substrate	substrate	NN
cord-341968-uc8i9h0m	275	16	proteins	protein	NNS
cord-341968-uc8i9h0m	275	17	of	of	IN
cord-341968-uc8i9h0m	275	18	furin	furin	NN
cord-341968-uc8i9h0m	275	19	in	in	IN
cord-341968-uc8i9h0m	275	20	the	the	DT
cord-341968-uc8i9h0m	275	21	human	human	JJ
cord-341968-uc8i9h0m	275	22	proteome	proteome	NN
cord-341968-uc8i9h0m	276	1	A	a	DT
cord-341968-uc8i9h0m	276	2	20	20	CD
cord-341968-uc8i9h0m	276	3	Residues	residue	NNS
cord-341968-uc8i9h0m	276	4	motif	motif	NN
cord-341968-uc8i9h0m	276	5	delineates	delineate	VBZ
cord-341968-uc8i9h0m	276	6	the	the	DT
cord-341968-uc8i9h0m	276	7	furin	furin	NN
cord-341968-uc8i9h0m	276	8	cleavage	cleavage	NN
cord-341968-uc8i9h0m	276	9	site	site	NN
cord-341968-uc8i9h0m	276	10	and	and	CC
cord-341968-uc8i9h0m	276	11	its	-PRON-	PRP$
cord-341968-uc8i9h0m	276	12	physical	physical	JJ
cord-341968-uc8i9h0m	276	13	properties	property	NNS
cord-341968-uc8i9h0m	276	14	may	may	MD
cord-341968-uc8i9h0m	276	15	influence	influence	VB
cord-341968-uc8i9h0m	276	16	viral	viral	JJ
cord-341968-uc8i9h0m	276	17	fusion	fusion	NN
cord-341968-uc8i9h0m	277	1	The	the	DT
cord-341968-uc8i9h0m	277	2	serpins	serpin	NNS
cord-341968-uc8i9h0m	277	3	are	be	VBP
cord-341968-uc8i9h0m	277	4	an	an	DT
cord-341968-uc8i9h0m	277	5	expanding	expand	VBG
cord-341968-uc8i9h0m	277	6	superfamily	superfamily	NN
cord-341968-uc8i9h0m	277	7	of	of	IN
cord-341968-uc8i9h0m	277	8	structurally	structurally	RB
cord-341968-uc8i9h0m	277	9	similar	similar	JJ
cord-341968-uc8i9h0m	277	10	but	but	CC
cord-341968-uc8i9h0m	277	11	functionally	functionally	RB
cord-341968-uc8i9h0m	277	12	diverse	diverse	JJ
cord-341968-uc8i9h0m	277	13	proteins	protein	NNS
cord-341968-uc8i9h0m	277	14	.	.	.
cord-341968-uc8i9h0m	278	1	Evolution	evolution	NN
cord-341968-uc8i9h0m	278	2	,	,	,
cord-341968-uc8i9h0m	278	3	mechanism	mechanism	NN
cord-341968-uc8i9h0m	278	4	of	of	IN
cord-341968-uc8i9h0m	278	5	inhibition	inhibition	NN
cord-341968-uc8i9h0m	278	6	,	,	,
cord-341968-uc8i9h0m	278	7	novel	novel	NN
cord-341968-uc8i9h0m	278	8	functions	function	NNS
cord-341968-uc8i9h0m	278	9	,	,	,
cord-341968-uc8i9h0m	278	10	and	and	CC
cord-341968-uc8i9h0m	278	11	a	a	DT
cord-341968-uc8i9h0m	278	12	revised	revise	VBN
cord-341968-uc8i9h0m	278	13	nomenclature	nomenclature	NN
cord-341968-uc8i9h0m	279	1	Inhibition	inhibition	NN
cord-341968-uc8i9h0m	279	2	of	of	IN
cord-341968-uc8i9h0m	279	3	soluble	soluble	JJ
cord-341968-uc8i9h0m	279	4	recombinant	recombinant	JJ
cord-341968-uc8i9h0m	279	5	furin	furin	NN
cord-341968-uc8i9h0m	279	6	by	by	IN
cord-341968-uc8i9h0m	279	7	human	human	JJ
cord-341968-uc8i9h0m	279	8	proteinase	proteinase	NN
cord-341968-uc8i9h0m	279	9	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	279	10	8	8	CD
cord-341968-uc8i9h0m	280	1	The	the	DT
cord-341968-uc8i9h0m	280	2	serpin	serpin	NN
cord-341968-uc8i9h0m	280	3	proteinase	proteinase	NN
cord-341968-uc8i9h0m	280	4	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	280	5	8	8	CD
cord-341968-uc8i9h0m	280	6	.	.	.
cord-341968-uc8i9h0m	281	1	An	an	DT
cord-341968-uc8i9h0m	281	2	endogenous	endogenous	JJ
cord-341968-uc8i9h0m	281	3	furin	furin	NN
cord-341968-uc8i9h0m	281	4	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	281	5	released	release	VBN
cord-341968-uc8i9h0m	281	6	from	from	IN
cord-341968-uc8i9h0m	281	7	human	human	JJ
cord-341968-uc8i9h0m	281	8	platelets	platelet	NNS
cord-341968-uc8i9h0m	281	9	Drosophila	Drosophila	NNP
cord-341968-uc8i9h0m	281	10	serpin	serpin	NN
cord-341968-uc8i9h0m	281	11	4	4	CD
cord-341968-uc8i9h0m	281	12	functions	function	NNS
cord-341968-uc8i9h0m	281	13	as	as	IN
cord-341968-uc8i9h0m	281	14	a	a	DT
cord-341968-uc8i9h0m	281	15	neuroserpin	neuroserpin	NNP
cord-341968-uc8i9h0m	281	16	-	-	HYPH
cord-341968-uc8i9h0m	281	17	like	like	JJ
cord-341968-uc8i9h0m	281	18	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	281	19	of	of	IN
cord-341968-uc8i9h0m	281	20	subtilisin	subtilisin	NNP
cord-341968-uc8i9h0m	281	21	-	-	HYPH
cord-341968-uc8i9h0m	281	22	like	like	JJ
cord-341968-uc8i9h0m	281	23	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	281	24	convertases	convertases	NNP
cord-341968-uc8i9h0m	282	1	The	the	DT
cord-341968-uc8i9h0m	282	2	Spn4	Spn4	NNP
cord-341968-uc8i9h0m	282	3	gene	gene	NN
cord-341968-uc8i9h0m	282	4	of	of	IN
cord-341968-uc8i9h0m	282	5	Drosophila	Drosophila	NNP
cord-341968-uc8i9h0m	282	6	encodes	encode	VBZ
cord-341968-uc8i9h0m	282	7	a	a	DT
cord-341968-uc8i9h0m	282	8	potent	potent	JJ
cord-341968-uc8i9h0m	282	9	furin	furin	NN
cord-341968-uc8i9h0m	282	10	-	-	HYPH
cord-341968-uc8i9h0m	282	11	directed	direct	VBN
cord-341968-uc8i9h0m	282	12	secretory	secretory	JJ
cord-341968-uc8i9h0m	282	13	pathway	pathway	NN
cord-341968-uc8i9h0m	282	14	serpin	serpin	NN
cord-341968-uc8i9h0m	282	15	A	a	DT
cord-341968-uc8i9h0m	282	16	proprotein	proprotein	FW
cord-341968-uc8i9h0m	282	17	convertase	convertase	NN
cord-341968-uc8i9h0m	282	18	-	-	HYPH
cord-341968-uc8i9h0m	282	19	inhibiting	inhibit	VBG
cord-341968-uc8i9h0m	282	20	serpin	serpin	NN
cord-341968-uc8i9h0m	282	21	with	with	IN
cord-341968-uc8i9h0m	282	22	an	an	DT
cord-341968-uc8i9h0m	282	23	endoplasmic	endoplasmic	NN
cord-341968-uc8i9h0m	282	24	reticulum	reticulum	NN
cord-341968-uc8i9h0m	282	25	targeting	target	VBG
cord-341968-uc8i9h0m	282	26	signal	signal	NN
cord-341968-uc8i9h0m	282	27	from	from	IN
cord-341968-uc8i9h0m	282	28	Branchiostoma	Branchiostoma	NNP
cord-341968-uc8i9h0m	282	29	lanceolatum	lanceolatum	NNP
cord-341968-uc8i9h0m	282	30	,	,	,
cord-341968-uc8i9h0m	282	31	a	a	DT
cord-341968-uc8i9h0m	282	32	close	close	JJ
cord-341968-uc8i9h0m	282	33	relative	relative	NN
cord-341968-uc8i9h0m	282	34	of	of	IN
cord-341968-uc8i9h0m	282	35	vertebrates	vertebrate	NNS
cord-341968-uc8i9h0m	282	36	Cutting	cut	VBG
cord-341968-uc8i9h0m	282	37	back	back	RB
cord-341968-uc8i9h0m	282	38	on	on	IN
cord-341968-uc8i9h0m	282	39	pro	pro	JJ
cord-341968-uc8i9h0m	282	40	-	-	JJ
cord-341968-uc8i9h0m	282	41	protein	protein	JJ
cord-341968-uc8i9h0m	282	42	convertases	convertase	NNS
cord-341968-uc8i9h0m	282	43	:	:	:
cord-341968-uc8i9h0m	283	1	The	the	DT
cord-341968-uc8i9h0m	283	2	latest	late	JJS
cord-341968-uc8i9h0m	283	3	approaches	approach	NNS
cord-341968-uc8i9h0m	283	4	to	to	IN
cord-341968-uc8i9h0m	283	5	pharmacological	pharmacological	JJ
cord-341968-uc8i9h0m	283	6	inhibition	inhibition	NN
cord-341968-uc8i9h0m	283	7	Inhibition	inhibition	NN
cord-341968-uc8i9h0m	283	8	of	of	IN
cord-341968-uc8i9h0m	283	9	HIV-1	HIV-1	NNP
cord-341968-uc8i9h0m	283	10	gp160-dependent	gp160-dependent	NNP
cord-341968-uc8i9h0m	283	11	membrane	membrane	NN
cord-341968-uc8i9h0m	283	12	fusion	fusion	NN
cord-341968-uc8i9h0m	283	13	by	by	IN
cord-341968-uc8i9h0m	283	14	a	a	DT
cord-341968-uc8i9h0m	283	15	furin	furin	NN
cord-341968-uc8i9h0m	283	16	-	-	HYPH
cord-341968-uc8i9h0m	283	17	directed	direct	VBN
cord-341968-uc8i9h0m	283	18	a1-antitrypsin	a1-antitrypsin	PRP
cord-341968-uc8i9h0m	283	19	variant	variant	JJ
cord-341968-uc8i9h0m	283	20	Current	current	JJ
cord-341968-uc8i9h0m	283	21	understanding	understanding	NN
cord-341968-uc8i9h0m	283	22	of	of	IN
cord-341968-uc8i9h0m	283	23	the	the	DT
cord-341968-uc8i9h0m	283	24	mechanism	mechanism	NN
cord-341968-uc8i9h0m	283	25	of	of	IN
cord-341968-uc8i9h0m	283	26	HPV	HPV	NNP
cord-341968-uc8i9h0m	283	27	infection	infection	NN
cord-341968-uc8i9h0m	284	1	The	the	DT
cord-341968-uc8i9h0m	284	2	role	role	NN
cord-341968-uc8i9h0m	284	3	of	of	IN
cord-341968-uc8i9h0m	284	4	furin	furin	NN
cord-341968-uc8i9h0m	284	5	in	in	IN
cord-341968-uc8i9h0m	284	6	papillomavirus	papillomavirus	NN
cord-341968-uc8i9h0m	284	7	infection	infection	NN
cord-341968-uc8i9h0m	285	1	The	the	DT
cord-341968-uc8i9h0m	285	2	initial	initial	JJ
cord-341968-uc8i9h0m	285	3	steps	step	NNS
cord-341968-uc8i9h0m	285	4	leading	lead	VBG
cord-341968-uc8i9h0m	285	5	to	to	IN
cord-341968-uc8i9h0m	285	6	papillomavirus	papillomavirus	NN
cord-341968-uc8i9h0m	285	7	infection	infection	NN
cord-341968-uc8i9h0m	285	8	occur	occur	VBP
cord-341968-uc8i9h0m	285	9	on	on	IN
cord-341968-uc8i9h0m	285	10	the	the	DT
cord-341968-uc8i9h0m	285	11	basement	basement	NN
cord-341968-uc8i9h0m	285	12	membrane	membrane	NN
cord-341968-uc8i9h0m	285	13	prior	prior	RB
cord-341968-uc8i9h0m	285	14	to	to	IN
cord-341968-uc8i9h0m	285	15	cell	cell	NN
cord-341968-uc8i9h0m	285	16	surface	surface	NN
cord-341968-uc8i9h0m	285	17	binding	bind	VBG
cord-341968-uc8i9h0m	285	18	Cleavage	cleavage	NN
cord-341968-uc8i9h0m	285	19	of	of	IN
cord-341968-uc8i9h0m	285	20	the	the	DT
cord-341968-uc8i9h0m	285	21	papillomavirus	papillomavirus	NN
cord-341968-uc8i9h0m	285	22	minor	minor	JJ
cord-341968-uc8i9h0m	285	23	capsid	capsid	NN
cord-341968-uc8i9h0m	285	24	protein	protein	NN
cord-341968-uc8i9h0m	285	25	,	,	,
cord-341968-uc8i9h0m	285	26	L2	L2	NNP
cord-341968-uc8i9h0m	285	27	,	,	,
cord-341968-uc8i9h0m	285	28	at	at	IN
cord-341968-uc8i9h0m	285	29	a	a	DT
cord-341968-uc8i9h0m	285	30	furin	furin	NN
cord-341968-uc8i9h0m	285	31	consensus	consensus	NN
cord-341968-uc8i9h0m	285	32	site	site	NN
cord-341968-uc8i9h0m	285	33	is	be	VBZ
cord-341968-uc8i9h0m	285	34	necessary	necessary	JJ
cord-341968-uc8i9h0m	285	35	for	for	IN
cord-341968-uc8i9h0m	285	36	infection	infection	NN
cord-341968-uc8i9h0m	286	1	Furin	furin	NN
cord-341968-uc8i9h0m	286	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	286	3	of	of	IN
cord-341968-uc8i9h0m	286	4	L2	l2	NN
cord-341968-uc8i9h0m	286	5	during	during	IN
cord-341968-uc8i9h0m	286	6	papillomavirus	papillomavirus	NN
cord-341968-uc8i9h0m	286	7	infection	infection	NN
cord-341968-uc8i9h0m	286	8	:	:	:
cord-341968-uc8i9h0m	287	1	Minimal	minimal	JJ
cord-341968-uc8i9h0m	287	2	dependence	dependence	NN
cord-341968-uc8i9h0m	287	3	on	on	IN
cord-341968-uc8i9h0m	287	4	cyclophilins	cyclophilins	NNP
cord-341968-uc8i9h0m	287	5	Cleavage	Cleavage	NNP
cord-341968-uc8i9h0m	287	6	of	of	IN
cord-341968-uc8i9h0m	287	7	the	the	DT
cord-341968-uc8i9h0m	287	8	HPV16	hpv16	NN
cord-341968-uc8i9h0m	287	9	minor	minor	JJ
cord-341968-uc8i9h0m	287	10	capsid	capsid	NN
cord-341968-uc8i9h0m	287	11	protein	protein	NN
cord-341968-uc8i9h0m	287	12	L2	l2	NN
cord-341968-uc8i9h0m	287	13	during	during	IN
cord-341968-uc8i9h0m	287	14	virion	virion	NN
cord-341968-uc8i9h0m	287	15	morphogenesis	morphogenesis	NN
cord-341968-uc8i9h0m	287	16	ablates	ablate	VBZ
cord-341968-uc8i9h0m	287	17	the	the	DT
cord-341968-uc8i9h0m	287	18	requirement	requirement	NN
cord-341968-uc8i9h0m	287	19	for	for	IN
cord-341968-uc8i9h0m	287	20	cellular	cellular	JJ
cord-341968-uc8i9h0m	287	21	furin	furin	NN
cord-341968-uc8i9h0m	287	22	during	during	IN
cord-341968-uc8i9h0m	287	23	de	de	FW
cord-341968-uc8i9h0m	287	24	novo	novo	NNP
cord-341968-uc8i9h0m	287	25	infection	infection	NN
cord-341968-uc8i9h0m	287	26	Efficient	Efficient	NNP
cord-341968-uc8i9h0m	287	27	intracellular	intracellular	JJ
cord-341968-uc8i9h0m	287	28	assembly	assembly	NN
cord-341968-uc8i9h0m	287	29	of	of	IN
cord-341968-uc8i9h0m	287	30	papillomaviral	papillomaviral	JJ
cord-341968-uc8i9h0m	287	31	vectors	vector	NNS
cord-341968-uc8i9h0m	287	32	Maturation	Maturation	NNP
cord-341968-uc8i9h0m	287	33	of	of	IN
cord-341968-uc8i9h0m	287	34	papillomavirus	papillomavirus	NN
cord-341968-uc8i9h0m	287	35	capsids	capsid	NNS
cord-341968-uc8i9h0m	288	1	Kallikrein-8	Kallikrein-8	NNP
cord-341968-uc8i9h0m	289	1	Proteolytically	Proteolytically	NNP
cord-341968-uc8i9h0m	290	1	Processes	Processes	NNP
cord-341968-uc8i9h0m	290	2	Human	Human	NNP
cord-341968-uc8i9h0m	290	3	Papillomaviruses	Papillomaviruses	NNPS
cord-341968-uc8i9h0m	290	4	in	in	IN
cord-341968-uc8i9h0m	290	5	the	the	DT
cord-341968-uc8i9h0m	290	6	Extracellular	Extracellular	NNP
cord-341968-uc8i9h0m	290	7	Space	Space	NNP
cord-341968-uc8i9h0m	291	1	to	to	TO
cord-341968-uc8i9h0m	291	2	Facilitate	facilitate	VB
cord-341968-uc8i9h0m	291	3	Entry	entry	NN
cord-341968-uc8i9h0m	291	4	into	into	IN
cord-341968-uc8i9h0m	291	5	Host	Host	NNP
cord-341968-uc8i9h0m	291	6	Cells	cell	NNS
cord-341968-uc8i9h0m	292	1	The	the	DT
cord-341968-uc8i9h0m	292	2	nuclear	nuclear	JJ
cord-341968-uc8i9h0m	292	3	retention	retention	NN
cord-341968-uc8i9h0m	292	4	signal	signal	NN
cord-341968-uc8i9h0m	292	5	of	of	IN
cord-341968-uc8i9h0m	292	6	HPV16	hpv16	NN
cord-341968-uc8i9h0m	293	1	L2	L2	NNP
cord-341968-uc8i9h0m	293	2	protein	protein	NN
cord-341968-uc8i9h0m	293	3	is	be	VBZ
cord-341968-uc8i9h0m	293	4	essential	essential	JJ
cord-341968-uc8i9h0m	293	5	for	for	IN
cord-341968-uc8i9h0m	293	6	incoming	incoming	JJ
cord-341968-uc8i9h0m	293	7	viral	viral	JJ
cord-341968-uc8i9h0m	293	8	genome	genome	NN
cord-341968-uc8i9h0m	293	9	to	to	TO
cord-341968-uc8i9h0m	293	10	transverse	transverse	VB
cord-341968-uc8i9h0m	293	11	the	the	DT
cord-341968-uc8i9h0m	293	12	trans	trans	JJ
cord-341968-uc8i9h0m	293	13	-	-	NNP
cord-341968-uc8i9h0m	293	14	Golgi	Golgi	NNP
cord-341968-uc8i9h0m	293	15	network	network	NN
cord-341968-uc8i9h0m	293	16	A	a	DT
cord-341968-uc8i9h0m	293	17	central	central	JJ
cord-341968-uc8i9h0m	293	18	region	region	NN
cord-341968-uc8i9h0m	293	19	in	in	IN
cord-341968-uc8i9h0m	293	20	the	the	DT
cord-341968-uc8i9h0m	293	21	minor	minor	JJ
cord-341968-uc8i9h0m	293	22	capsid	capsid	NN
cord-341968-uc8i9h0m	293	23	protein	protein	NN
cord-341968-uc8i9h0m	293	24	of	of	IN
cord-341968-uc8i9h0m	293	25	papillomaviruses	papillomaviruse	NNS
cord-341968-uc8i9h0m	293	26	facilitates	facilitate	VBZ
cord-341968-uc8i9h0m	293	27	viral	viral	JJ
cord-341968-uc8i9h0m	293	28	genome	genome	NN
cord-341968-uc8i9h0m	293	29	tethering	tethering	NN
cord-341968-uc8i9h0m	293	30	and	and	CC
cord-341968-uc8i9h0m	293	31	membrane	membrane	NN
cord-341968-uc8i9h0m	293	32	penetration	penetration	NN
cord-341968-uc8i9h0m	293	33	for	for	IN
cord-341968-uc8i9h0m	293	34	mitotic	mitotic	JJ
cord-341968-uc8i9h0m	293	35	nuclear	nuclear	JJ
cord-341968-uc8i9h0m	293	36	entry	entry	NN
cord-341968-uc8i9h0m	293	37	Microarray	Microarray	NNP
cord-341968-uc8i9h0m	293	38	analysis	analysis	NN
cord-341968-uc8i9h0m	293	39	of	of	IN
cord-341968-uc8i9h0m	293	40	human	human	JJ
cord-341968-uc8i9h0m	293	41	keratinocytes	keratinocyte	NNS
cord-341968-uc8i9h0m	293	42	from	from	IN
cord-341968-uc8i9h0m	293	43	different	different	JJ
cord-341968-uc8i9h0m	293	44	anatomic	anatomic	JJ
cord-341968-uc8i9h0m	293	45	sites	site	NNS
cord-341968-uc8i9h0m	293	46	reveals	reveal	VBZ
cord-341968-uc8i9h0m	293	47	site	site	NN
cord-341968-uc8i9h0m	293	48	-	-	HYPH
cord-341968-uc8i9h0m	293	49	specific	specific	JJ
cord-341968-uc8i9h0m	293	50	immune	immune	JJ
cord-341968-uc8i9h0m	293	51	signaling	signaling	NN
cord-341968-uc8i9h0m	293	52	and	and	CC
cord-341968-uc8i9h0m	293	53	responses	response	NNS
cord-341968-uc8i9h0m	293	54	to	to	IN
cord-341968-uc8i9h0m	293	55	human	human	JJ
cord-341968-uc8i9h0m	293	56	papillomavirus	papillomavirus	NN
cord-341968-uc8i9h0m	293	57	type	type	NN
cord-341968-uc8i9h0m	293	58	16	16	CD
cord-341968-uc8i9h0m	293	59	transfection	transfection	NN
cord-341968-uc8i9h0m	293	60	Proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	293	61	processing	processing	NN
cord-341968-uc8i9h0m	293	62	of	of	IN
cord-341968-uc8i9h0m	293	63	human	human	JJ
cord-341968-uc8i9h0m	293	64	cytomegalovirus	cytomegalovirus	NN
cord-341968-uc8i9h0m	293	65	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	293	66	B	B	NNP
cord-341968-uc8i9h0m	293	67	(	(	-LRB-
cord-341968-uc8i9h0m	293	68	gpUL55	gpUL55	NNP
cord-341968-uc8i9h0m	293	69	)	)	-RRB-
cord-341968-uc8i9h0m	293	70	is	be	VBZ
cord-341968-uc8i9h0m	293	71	mediated	mediate	VBN
cord-341968-uc8i9h0m	293	72	by	by	IN
cord-341968-uc8i9h0m	293	73	the	the	DT
cord-341968-uc8i9h0m	293	74	human	human	JJ
cord-341968-uc8i9h0m	293	75	endoprotease	endoprotease	NN
cord-341968-uc8i9h0m	293	76	furin	furin	NN
cord-341968-uc8i9h0m	293	77	Glycoprotein	Glycoprotein	NNP
cord-341968-uc8i9h0m	293	78	B	B	NNP
cord-341968-uc8i9h0m	293	79	of	of	IN
cord-341968-uc8i9h0m	293	80	equine	equine	JJ
cord-341968-uc8i9h0m	293	81	herpesvirus	herpesvirus	NN
cord-341968-uc8i9h0m	293	82	type	type	NN
cord-341968-uc8i9h0m	293	83	1	1	CD
cord-341968-uc8i9h0m	293	84	has	have	VBZ
cord-341968-uc8i9h0m	294	1	two	two	CD
cord-341968-uc8i9h0m	294	2	recognition	recognition	NN
cord-341968-uc8i9h0m	294	3	sites	site	NNS
cord-341968-uc8i9h0m	294	4	for	for	IN
cord-341968-uc8i9h0m	294	5	subtilisin	subtilisin	NNS
cord-341968-uc8i9h0m	294	6	-	-	HYPH
cord-341968-uc8i9h0m	294	7	like	like	JJ
cord-341968-uc8i9h0m	294	8	proteases	protease	NNS
cord-341968-uc8i9h0m	294	9	that	that	WDT
cord-341968-uc8i9h0m	294	10	are	be	VBP
cord-341968-uc8i9h0m	294	11	cleaved	cleave	VBN
cord-341968-uc8i9h0m	294	12	by	by	IN
cord-341968-uc8i9h0m	294	13	furin	furin	NN
cord-341968-uc8i9h0m	294	14	Glycoprotein	Glycoprotein	NNP
cord-341968-uc8i9h0m	294	15	B	B	NNP
cord-341968-uc8i9h0m	294	16	cleavage	cleavage	NN
cord-341968-uc8i9h0m	294	17	is	be	VBZ
cord-341968-uc8i9h0m	294	18	important	important	JJ
cord-341968-uc8i9h0m	294	19	for	for	IN
cord-341968-uc8i9h0m	294	20	murid	murid	NN
cord-341968-uc8i9h0m	294	21	herpesvirus	herpesvirus	NNP
cord-341968-uc8i9h0m	294	22	4	4	CD
cord-341968-uc8i9h0m	294	23	to	to	TO
cord-341968-uc8i9h0m	294	24	infect	infect	VB
cord-341968-uc8i9h0m	294	25	myeloid	myeloid	JJ
cord-341968-uc8i9h0m	294	26	cells	cell	NNS
cord-341968-uc8i9h0m	294	27	Mutagenesis	Mutagenesis	NNP
cord-341968-uc8i9h0m	294	28	of	of	IN
cord-341968-uc8i9h0m	294	29	varicella	varicella	NN
cord-341968-uc8i9h0m	294	30	-	-	HYPH
cord-341968-uc8i9h0m	294	31	zoster	zoster	NN
cord-341968-uc8i9h0m	294	32	virus	virus	NN
cord-341968-uc8i9h0m	294	33	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	294	34	B	b	NN
cord-341968-uc8i9h0m	294	35	:	:	:
cord-341968-uc8i9h0m	294	36	Putative	putative	JJ
cord-341968-uc8i9h0m	294	37	fusion	fusion	NN
cord-341968-uc8i9h0m	294	38	loop	loop	NN
cord-341968-uc8i9h0m	294	39	residues	residue	NNS
cord-341968-uc8i9h0m	294	40	are	be	VBP
cord-341968-uc8i9h0m	294	41	essential	essential	JJ
cord-341968-uc8i9h0m	294	42	for	for	IN
cord-341968-uc8i9h0m	294	43	viral	viral	JJ
cord-341968-uc8i9h0m	294	44	replication	replication	NN
cord-341968-uc8i9h0m	294	45	,	,	,
cord-341968-uc8i9h0m	294	46	and	and	CC
cord-341968-uc8i9h0m	294	47	the	the	DT
cord-341968-uc8i9h0m	294	48	furin	furin	NN
cord-341968-uc8i9h0m	294	49	cleavage	cleavage	NN
cord-341968-uc8i9h0m	294	50	motif	motif	NN
cord-341968-uc8i9h0m	294	51	contributes	contribute	VBZ
cord-341968-uc8i9h0m	294	52	to	to	IN
cord-341968-uc8i9h0m	294	53	pathogenesis	pathogenesis	NN
cord-341968-uc8i9h0m	294	54	in	in	IN
cord-341968-uc8i9h0m	294	55	skin	skin	NN
cord-341968-uc8i9h0m	294	56	tissue	tissue	NN
cord-341968-uc8i9h0m	294	57	in	in	IN
cord-341968-uc8i9h0m	294	58	vivo	vivo	NNP
cord-341968-uc8i9h0m	294	59	Cleavage	cleavage	NN
cord-341968-uc8i9h0m	294	60	of	of	IN
cord-341968-uc8i9h0m	294	61	Epstein	Epstein	NNP
cord-341968-uc8i9h0m	294	62	-	-	HYPH
cord-341968-uc8i9h0m	294	63	Barr	Barr	NNP
cord-341968-uc8i9h0m	294	64	virus	virus	NN
cord-341968-uc8i9h0m	294	65	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	294	66	B	b	NN
cord-341968-uc8i9h0m	294	67	is	be	VBZ
cord-341968-uc8i9h0m	294	68	required	require	VBN
cord-341968-uc8i9h0m	294	69	for	for	IN
cord-341968-uc8i9h0m	294	70	full	full	JJ
cord-341968-uc8i9h0m	294	71	function	function	NN
cord-341968-uc8i9h0m	294	72	in	in	IN
cord-341968-uc8i9h0m	294	73	cell	cell	NN
cord-341968-uc8i9h0m	294	74	-	-	HYPH
cord-341968-uc8i9h0m	294	75	cell	cell	NN
cord-341968-uc8i9h0m	294	76	fusion	fusion	NN
cord-341968-uc8i9h0m	294	77	with	with	IN
cord-341968-uc8i9h0m	294	78	both	both	DT
cord-341968-uc8i9h0m	294	79	epithelial	epithelial	NN
cord-341968-uc8i9h0m	294	80	and	and	CC
cord-341968-uc8i9h0m	294	81	B	b	NN
cord-341968-uc8i9h0m	294	82	cells	cell	NNS
cord-341968-uc8i9h0m	294	83	Positively	positively	RB
cord-341968-uc8i9h0m	294	84	selected	select	VBN
cord-341968-uc8i9h0m	294	85	sites	site	NNS
cord-341968-uc8i9h0m	294	86	at	at	IN
cord-341968-uc8i9h0m	294	87	HCMV	HCMV	NNP
cord-341968-uc8i9h0m	295	1	gB	gB	NNP
cord-341968-uc8i9h0m	295	2	furin	furin	NN
cord-341968-uc8i9h0m	295	3	processing	processing	NN
cord-341968-uc8i9h0m	295	4	region	region	NN
cord-341968-uc8i9h0m	295	5	and	and	CC
cord-341968-uc8i9h0m	295	6	their	-PRON-	PRP$
cord-341968-uc8i9h0m	295	7	effects	effect	NNS
cord-341968-uc8i9h0m	295	8	in	in	IN
cord-341968-uc8i9h0m	295	9	cleavage	cleavage	NN
cord-341968-uc8i9h0m	295	10	efficiency	efficiency	NN
cord-341968-uc8i9h0m	296	1	The	the	DT
cord-341968-uc8i9h0m	296	2	3.8	3.8	CD
cord-341968-uc8i9h0m	296	3	Å	å	NN
cord-341968-uc8i9h0m	296	4	resolution	resolution	NN
cord-341968-uc8i9h0m	296	5	cryo	cryo	NN
cord-341968-uc8i9h0m	296	6	-	-	HYPH
cord-341968-uc8i9h0m	296	7	EM	EM	NNP
cord-341968-uc8i9h0m	296	8	structure	structure	NN
cord-341968-uc8i9h0m	296	9	of	of	IN
cord-341968-uc8i9h0m	296	10	Zika	Zika	NNP
cord-341968-uc8i9h0m	296	11	virus	virus	NN
cord-341968-uc8i9h0m	297	1	A	a	DT
cord-341968-uc8i9h0m	297	2	structural	structural	JJ
cord-341968-uc8i9h0m	297	3	perspective	perspective	NN
cord-341968-uc8i9h0m	297	4	of	of	IN
cord-341968-uc8i9h0m	297	5	the	the	DT
cord-341968-uc8i9h0m	297	6	flavivirus	flavivirus	NNP
cord-341968-uc8i9h0m	297	7	life	life	NN
cord-341968-uc8i9h0m	297	8	cycle	cycle	NN
cord-341968-uc8i9h0m	297	9	Functional	functional	JJ
cord-341968-uc8i9h0m	297	10	importance	importance	NN
cord-341968-uc8i9h0m	297	11	of	of	IN
cord-341968-uc8i9h0m	297	12	dengue	dengue	NN
cord-341968-uc8i9h0m	297	13	virus	virus	NN
cord-341968-uc8i9h0m	297	14	maturation	maturation	NN
cord-341968-uc8i9h0m	297	15	:	:	:
cord-341968-uc8i9h0m	298	1	Infectious	infectious	JJ
cord-341968-uc8i9h0m	298	2	properties	property	NNS
cord-341968-uc8i9h0m	298	3	of	of	IN
cord-341968-uc8i9h0m	298	4	immature	immature	JJ
cord-341968-uc8i9h0m	298	5	virions	virion	NNS
cord-341968-uc8i9h0m	298	6	Antibodies	Antibodies	NNPS
cord-341968-uc8i9h0m	298	7	against	against	IN
cord-341968-uc8i9h0m	298	8	the	the	DT
cord-341968-uc8i9h0m	298	9	envelope	envelope	NN
cord-341968-uc8i9h0m	298	10	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	298	11	promote	promote	VBP
cord-341968-uc8i9h0m	298	12	infectivity	infectivity	NN
cord-341968-uc8i9h0m	298	13	of	of	IN
cord-341968-uc8i9h0m	298	14	immature	immature	JJ
cord-341968-uc8i9h0m	298	15	dengue	dengue	NN
cord-341968-uc8i9h0m	298	16	virus	virus	NN
cord-341968-uc8i9h0m	298	17	serotype	serotype	NN
cord-341968-uc8i9h0m	298	18	2	2	CD
cord-341968-uc8i9h0m	298	19	Zika	Zika	NNP
cord-341968-uc8i9h0m	298	20	virus	virus	NN
cord-341968-uc8i9h0m	298	21	pathogenesis	pathogenesis	NN
cord-341968-uc8i9h0m	298	22	and	and	CC
cord-341968-uc8i9h0m	298	23	tissue	tissue	NN
cord-341968-uc8i9h0m	298	24	tropism	tropism	NN
cord-341968-uc8i9h0m	298	25	Persistence	persistence	NN
cord-341968-uc8i9h0m	298	26	of	of	IN
cord-341968-uc8i9h0m	298	27	Zika	Zika	NNP
cord-341968-uc8i9h0m	298	28	virus	virus	NN
cord-341968-uc8i9h0m	298	29	in	in	IN
cord-341968-uc8i9h0m	298	30	body	body	NN
cord-341968-uc8i9h0m	298	31	fluids	fluid	NNS
cord-341968-uc8i9h0m	298	32	-	-	:
cord-341968-uc8i9h0m	298	33	preliminary	preliminary	JJ
cord-341968-uc8i9h0m	298	34	report	report	NN
cord-341968-uc8i9h0m	298	35	Testicular	testicular	JJ
cord-341968-uc8i9h0m	298	36	expression	expression	NN
cord-341968-uc8i9h0m	298	37	of	of	IN
cord-341968-uc8i9h0m	298	38	PC4	pc4	NN
cord-341968-uc8i9h0m	298	39	in	in	IN
cord-341968-uc8i9h0m	298	40	the	the	DT
cord-341968-uc8i9h0m	298	41	rat	rat	NN
cord-341968-uc8i9h0m	298	42	:	:	:
cord-341968-uc8i9h0m	299	1	Molecular	molecular	JJ
cord-341968-uc8i9h0m	299	2	diversity	diversity	NN
cord-341968-uc8i9h0m	299	3	of	of	IN
cord-341968-uc8i9h0m	299	4	a	a	DT
cord-341968-uc8i9h0m	299	5	novel	novel	JJ
cord-341968-uc8i9h0m	299	6	germ	germ	NN
cord-341968-uc8i9h0m	299	7	cell	cell	NN
cord-341968-uc8i9h0m	299	8	-	-	HYPH
cord-341968-uc8i9h0m	299	9	specific	specific	JJ
cord-341968-uc8i9h0m	299	10	Kex2	Kex2	NNP
cord-341968-uc8i9h0m	299	11	/	/	SYM
cord-341968-uc8i9h0m	299	12	subtilisin	subtilisin	NNP
cord-341968-uc8i9h0m	299	13	-	-	HYPH
cord-341968-uc8i9h0m	299	14	like	like	JJ
cord-341968-uc8i9h0m	299	15	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	299	16	convertase	convertase	NN
cord-341968-uc8i9h0m	299	17	Changing	change	VBG
cord-341968-uc8i9h0m	299	18	the	the	DT
cord-341968-uc8i9h0m	299	19	protease	protease	NN
cord-341968-uc8i9h0m	299	20	specificity	specificity	NN
cord-341968-uc8i9h0m	299	21	for	for	IN
cord-341968-uc8i9h0m	299	22	activation	activation	NN
cord-341968-uc8i9h0m	299	23	of	of	IN
cord-341968-uc8i9h0m	299	24	a	a	DT
cord-341968-uc8i9h0m	299	25	flavivirus	flavivirus	NN
cord-341968-uc8i9h0m	299	26	,	,	,
cord-341968-uc8i9h0m	299	27	tick	tick	VB
cord-341968-uc8i9h0m	299	28	-	-	HYPH
cord-341968-uc8i9h0m	299	29	borne	bear	VBN
cord-341968-uc8i9h0m	299	30	encephalitis	encephalitis	JJ
cord-341968-uc8i9h0m	299	31	virus	virus	NN
cord-341968-uc8i9h0m	299	32	Comparative	comparative	JJ
cord-341968-uc8i9h0m	299	33	analysis	analysis	NN
cord-341968-uc8i9h0m	299	34	between	between	IN
cord-341968-uc8i9h0m	299	35	flaviviruses	flavivirus	NNS
cord-341968-uc8i9h0m	299	36	reveals	reveal	VBZ
cord-341968-uc8i9h0m	299	37	specific	specific	JJ
cord-341968-uc8i9h0m	299	38	neural	neural	JJ
cord-341968-uc8i9h0m	299	39	stem	stem	NN
cord-341968-uc8i9h0m	299	40	cell	cell	NN
cord-341968-uc8i9h0m	299	41	tropism	tropism	NN
cord-341968-uc8i9h0m	299	42	for	for	IN
cord-341968-uc8i9h0m	299	43	Zika	Zika	NNP
cord-341968-uc8i9h0m	299	44	virus	virus	NN
cord-341968-uc8i9h0m	299	45	in	in	IN
cord-341968-uc8i9h0m	299	46	the	the	DT
cord-341968-uc8i9h0m	299	47	mouse	mouse	NN
cord-341968-uc8i9h0m	299	48	developing	develop	VBG
cord-341968-uc8i9h0m	299	49	neocortex	neocortex	NN
cord-341968-uc8i9h0m	299	50	Zika	Zika	NNP
cord-341968-uc8i9h0m	299	51	virus	virus	NN
cord-341968-uc8i9h0m	299	52	impairs	impair	VBZ
cord-341968-uc8i9h0m	299	53	growth	growth	NN
cord-341968-uc8i9h0m	299	54	in	in	IN
cord-341968-uc8i9h0m	299	55	human	human	JJ
cord-341968-uc8i9h0m	299	56	neurospheres	neurosphere	NNS
cord-341968-uc8i9h0m	299	57	and	and	CC
cord-341968-uc8i9h0m	299	58	brain	brain	NN
cord-341968-uc8i9h0m	299	59	organoids	organoids	NNP
cord-341968-uc8i9h0m	299	60	Glycoprotein	Glycoprotein	NNP
cord-341968-uc8i9h0m	299	61	organization	organization	NN
cord-341968-uc8i9h0m	299	62	of	of	IN
cord-341968-uc8i9h0m	299	63	Chikungunya	Chikungunya	NNP
cord-341968-uc8i9h0m	299	64	virus	virus	NN
cord-341968-uc8i9h0m	299	65	particles	particle	NNS
cord-341968-uc8i9h0m	299	66	revealed	reveal	VBN
cord-341968-uc8i9h0m	299	67	by	by	IN
cord-341968-uc8i9h0m	299	68	X	x	NN
cord-341968-uc8i9h0m	299	69	-	-	NN
cord-341968-uc8i9h0m	299	70	ray	ray	NN
cord-341968-uc8i9h0m	299	71	crystallography	crystallography	NN
cord-341968-uc8i9h0m	299	72	Furin	furin	NN
cord-341968-uc8i9h0m	299	73	processing	processing	NN
cord-341968-uc8i9h0m	299	74	and	and	CC
cord-341968-uc8i9h0m	299	75	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	299	76	activation	activation	NN
cord-341968-uc8i9h0m	299	77	of	of	IN
cord-341968-uc8i9h0m	299	78	Semliki	Semliki	NNP
cord-341968-uc8i9h0m	299	79	Forest	Forest	NNP
cord-341968-uc8i9h0m	299	80	virus	virus	NN
cord-341968-uc8i9h0m	299	81	Inhibition	inhibition	NN
cord-341968-uc8i9h0m	299	82	of	of	IN
cord-341968-uc8i9h0m	299	83	Chikungunya	Chikungunya	NNP
cord-341968-uc8i9h0m	299	84	virus	virus	NN
cord-341968-uc8i9h0m	299	85	infection	infection	NN
cord-341968-uc8i9h0m	299	86	in	in	IN
cord-341968-uc8i9h0m	299	87	cultured	cultured	JJ
cord-341968-uc8i9h0m	299	88	human	human	JJ
cord-341968-uc8i9h0m	299	89	muscle	muscle	NN
cord-341968-uc8i9h0m	299	90	cells	cell	NNS
cord-341968-uc8i9h0m	299	91	by	by	IN
cord-341968-uc8i9h0m	299	92	furin	furin	NN
cord-341968-uc8i9h0m	299	93	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	299	94	:	:	:
cord-341968-uc8i9h0m	300	1	Impairment	impairment	NN
cord-341968-uc8i9h0m	300	2	of	of	IN
cord-341968-uc8i9h0m	300	3	the	the	DT
cord-341968-uc8i9h0m	300	4	maturation	maturation	NN
cord-341968-uc8i9h0m	300	5	of	of	IN
cord-341968-uc8i9h0m	300	6	the	the	DT
cord-341968-uc8i9h0m	300	7	E2	E2	NNP
cord-341968-uc8i9h0m	300	8	surface	surface	NN
cord-341968-uc8i9h0m	300	9	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	300	10	Host	host	NN
cord-341968-uc8i9h0m	300	11	cell	cell	NN
cord-341968-uc8i9h0m	300	12	proteases	protease	NNS
cord-341968-uc8i9h0m	300	13	:	:	:
cord-341968-uc8i9h0m	300	14	Critical	critical	JJ
cord-341968-uc8i9h0m	300	15	determinants	determinant	NNS
cord-341968-uc8i9h0m	300	16	of	of	IN
cord-341968-uc8i9h0m	300	17	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	300	18	tropism	tropism	NN
cord-341968-uc8i9h0m	300	19	and	and	CC
cord-341968-uc8i9h0m	300	20	pathogenesis	pathogenesis	NN
cord-341968-uc8i9h0m	300	21	Cathepsin	Cathepsin	NNP
cord-341968-uc8i9h0m	300	22	L	L	NNP
cord-341968-uc8i9h0m	300	23	functionally	functionally	RB
cord-341968-uc8i9h0m	300	24	cleaves	cleave	VBZ
cord-341968-uc8i9h0m	300	25	the	the	DT
cord-341968-uc8i9h0m	300	26	severe	severe	JJ
cord-341968-uc8i9h0m	300	27	acute	acute	JJ
cord-341968-uc8i9h0m	300	28	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	300	29	syndrome	syndrome	NN
cord-341968-uc8i9h0m	300	30	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	300	31	class	class	NN
cord-341968-uc8i9h0m	300	32	I	-PRON-	PRP
cord-341968-uc8i9h0m	300	33	fusion	fusion	NN
cord-341968-uc8i9h0m	300	34	protein	protein	NN
cord-341968-uc8i9h0m	300	35	upstream	upstream	RB
cord-341968-uc8i9h0m	300	36	of	of	IN
cord-341968-uc8i9h0m	300	37	rather	rather	RB
cord-341968-uc8i9h0m	300	38	than	than	IN
cord-341968-uc8i9h0m	300	39	adjacent	adjacent	JJ
cord-341968-uc8i9h0m	300	40	to	to	IN
cord-341968-uc8i9h0m	300	41	the	the	DT
cord-341968-uc8i9h0m	300	42	fusion	fusion	NN
cord-341968-uc8i9h0m	300	43	peptide	peptide	NN
cord-341968-uc8i9h0m	301	1	Different	different	JJ
cord-341968-uc8i9h0m	301	2	host	host	NN
cord-341968-uc8i9h0m	301	3	cell	cell	NN
cord-341968-uc8i9h0m	301	4	proteases	protease	NNS
cord-341968-uc8i9h0m	301	5	activate	activate	VBP
cord-341968-uc8i9h0m	301	6	the	the	DT
cord-341968-uc8i9h0m	301	7	SARS	SARS	NNP
cord-341968-uc8i9h0m	301	8	-	-	HYPH
cord-341968-uc8i9h0m	301	9	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	301	10	spike	spike	NN
cord-341968-uc8i9h0m	301	11	-	-	HYPH
cord-341968-uc8i9h0m	301	12	protein	protein	NN
cord-341968-uc8i9h0m	301	13	for	for	IN
cord-341968-uc8i9h0m	301	14	cell	cell	NN
cord-341968-uc8i9h0m	301	15	-	-	HYPH
cord-341968-uc8i9h0m	301	16	cell	cell	NN
cord-341968-uc8i9h0m	301	17	and	and	CC
cord-341968-uc8i9h0m	301	18	virus	virus	NN
cord-341968-uc8i9h0m	301	19	-	-	HYPH
cord-341968-uc8i9h0m	301	20	cell	cell	NN
cord-341968-uc8i9h0m	301	21	fusion	fusion	NN
cord-341968-uc8i9h0m	301	22	Proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	301	23	activation	activation	NN
cord-341968-uc8i9h0m	301	24	of	of	IN
cord-341968-uc8i9h0m	301	25	the	the	DT
cord-341968-uc8i9h0m	301	26	spike	spike	NN
cord-341968-uc8i9h0m	301	27	protein	protein	NN
cord-341968-uc8i9h0m	301	28	at	at	IN
cord-341968-uc8i9h0m	301	29	a	a	DT
cord-341968-uc8i9h0m	301	30	novel	novel	NN
cord-341968-uc8i9h0m	301	31	RRRR	RRRR	NNP
cord-341968-uc8i9h0m	301	32	/	/	SYM
cord-341968-uc8i9h0m	301	33	S	s	NN
cord-341968-uc8i9h0m	301	34	motif	motif	NN
cord-341968-uc8i9h0m	301	35	is	be	VBZ
cord-341968-uc8i9h0m	301	36	implicated	implicate	VBN
cord-341968-uc8i9h0m	301	37	in	in	IN
cord-341968-uc8i9h0m	301	38	furin	furin	NN
cord-341968-uc8i9h0m	301	39	-	-	HYPH
cord-341968-uc8i9h0m	301	40	dependent	dependent	JJ
cord-341968-uc8i9h0m	301	41	entry	entry	NN
cord-341968-uc8i9h0m	301	42	,	,	,
cord-341968-uc8i9h0m	301	43	syncytium	syncytium	NN
cord-341968-uc8i9h0m	301	44	formation	formation	NN
cord-341968-uc8i9h0m	301	45	,	,	,
cord-341968-uc8i9h0m	301	46	and	and	CC
cord-341968-uc8i9h0m	301	47	infectivity	infectivity	NN
cord-341968-uc8i9h0m	301	48	of	of	IN
cord-341968-uc8i9h0m	301	49	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	301	50	infectious	infectious	JJ
cord-341968-uc8i9h0m	301	51	bronchitis	bronchitis	NN
cord-341968-uc8i9h0m	301	52	virus	virus	NN
cord-341968-uc8i9h0m	301	53	in	in	IN
cord-341968-uc8i9h0m	301	54	cultured	cultured	JJ
cord-341968-uc8i9h0m	301	55	cells	cell	NNS
cord-341968-uc8i9h0m	301	56	Activation	Activation	NNP
cord-341968-uc8i9h0m	301	57	of	of	IN
cord-341968-uc8i9h0m	301	58	the	the	DT
cord-341968-uc8i9h0m	301	59	SARS	SARS	NNP
cord-341968-uc8i9h0m	301	60	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	301	61	spike	spike	NN
cord-341968-uc8i9h0m	301	62	protein	protein	NN
cord-341968-uc8i9h0m	301	63	via	via	IN
cord-341968-uc8i9h0m	301	64	sequential	sequential	JJ
cord-341968-uc8i9h0m	301	65	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	301	66	cleavage	cleavage	NN
cord-341968-uc8i9h0m	301	67	at	at	IN
cord-341968-uc8i9h0m	301	68	two	two	CD
cord-341968-uc8i9h0m	301	69	distinct	distinct	JJ
cord-341968-uc8i9h0m	301	70	sites	site	NNS
cord-341968-uc8i9h0m	301	71	Host	host	NN
cord-341968-uc8i9h0m	301	72	cell	cell	NN
cord-341968-uc8i9h0m	301	73	entry	entry	NN
cord-341968-uc8i9h0m	301	74	of	of	IN
cord-341968-uc8i9h0m	301	75	Middle	Middle	NNP
cord-341968-uc8i9h0m	301	76	East	East	NNP
cord-341968-uc8i9h0m	301	77	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	301	78	syndrome	syndrome	NN
cord-341968-uc8i9h0m	301	79	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	301	80	after	after	IN
cord-341968-uc8i9h0m	301	81	two	two	CD
cord-341968-uc8i9h0m	301	82	-	-	HYPH
cord-341968-uc8i9h0m	301	83	step	step	NN
cord-341968-uc8i9h0m	301	84	,	,	,
cord-341968-uc8i9h0m	301	85	furin	furin	NN
cord-341968-uc8i9h0m	301	86	-	-	HYPH
cord-341968-uc8i9h0m	301	87	mediated	mediate	VBN
cord-341968-uc8i9h0m	301	88	activation	activation	NN
cord-341968-uc8i9h0m	301	89	of	of	IN
cord-341968-uc8i9h0m	301	90	the	the	DT
cord-341968-uc8i9h0m	301	91	spike	spike	NN
cord-341968-uc8i9h0m	301	92	protein	protein	NN
cord-341968-uc8i9h0m	301	93	Proteolytic	Proteolytic	NNP
cord-341968-uc8i9h0m	301	94	processing	processing	NN
cord-341968-uc8i9h0m	301	95	of	of	IN
cord-341968-uc8i9h0m	301	96	Middle	Middle	NNP
cord-341968-uc8i9h0m	301	97	East	East	NNP
cord-341968-uc8i9h0m	301	98	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	301	99	syndrome	syndrome	NN
cord-341968-uc8i9h0m	301	100	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	301	101	spikes	spike	NNS
cord-341968-uc8i9h0m	301	102	expands	expand	VBZ
cord-341968-uc8i9h0m	301	103	virus	virus	NN
cord-341968-uc8i9h0m	301	104	tropism	tropism	NN
cord-341968-uc8i9h0m	301	105	Characterization	characterization	NN
cord-341968-uc8i9h0m	301	106	of	of	IN
cord-341968-uc8i9h0m	301	107	cellular	cellular	JJ
cord-341968-uc8i9h0m	301	108	furin	furin	NN
cord-341968-uc8i9h0m	301	109	content	content	NN
cord-341968-uc8i9h0m	301	110	as	as	IN
cord-341968-uc8i9h0m	301	111	a	a	DT
cord-341968-uc8i9h0m	301	112	potential	potential	JJ
cord-341968-uc8i9h0m	301	113	factor	factor	NN
cord-341968-uc8i9h0m	301	114	determining	determine	VBG
cord-341968-uc8i9h0m	301	115	the	the	DT
cord-341968-uc8i9h0m	301	116	susceptibility	susceptibility	NN
cord-341968-uc8i9h0m	301	117	of	of	IN
cord-341968-uc8i9h0m	301	118	cultured	cultured	JJ
cord-341968-uc8i9h0m	301	119	human	human	JJ
cord-341968-uc8i9h0m	301	120	and	and	CC
cord-341968-uc8i9h0m	301	121	animal	animal	NN
cord-341968-uc8i9h0m	301	122	cells	cell	NNS
cord-341968-uc8i9h0m	301	123	to	to	IN
cord-341968-uc8i9h0m	301	124	coronavirus	coronavirus	VB
cord-341968-uc8i9h0m	301	125	infectious	infectious	JJ
cord-341968-uc8i9h0m	301	126	bronchitis	bronchitis	NN
cord-341968-uc8i9h0m	301	127	virus	virus	NN
cord-341968-uc8i9h0m	301	128	infection	infection	NN
cord-341968-uc8i9h0m	301	129	Multiple	multiple	JJ
cord-341968-uc8i9h0m	301	130	organ	organ	NN
cord-341968-uc8i9h0m	301	131	infection	infection	NN
cord-341968-uc8i9h0m	301	132	and	and	CC
cord-341968-uc8i9h0m	301	133	the	the	DT
cord-341968-uc8i9h0m	301	134	pathogenesis	pathogenesis	NN
cord-341968-uc8i9h0m	301	135	of	of	IN
cord-341968-uc8i9h0m	301	136	SARS	SARS	NNP
cord-341968-uc8i9h0m	301	137	Middle	Middle	NNP
cord-341968-uc8i9h0m	301	138	East	East	NNP
cord-341968-uc8i9h0m	301	139	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	301	140	syndrome	syndrome	NN
cord-341968-uc8i9h0m	301	141	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	301	142	spike	spike	NN
cord-341968-uc8i9h0m	301	143	protein	protein	NN
cord-341968-uc8i9h0m	301	144	is	be	VBZ
cord-341968-uc8i9h0m	301	145	not	not	RB
cord-341968-uc8i9h0m	301	146	activated	activate	VBN
cord-341968-uc8i9h0m	301	147	directly	directly	RB
cord-341968-uc8i9h0m	301	148	by	by	IN
cord-341968-uc8i9h0m	301	149	cellular	cellular	JJ
cord-341968-uc8i9h0m	301	150	furin	furin	NN
cord-341968-uc8i9h0m	301	151	during	during	IN
cord-341968-uc8i9h0m	301	152	viral	viral	JJ
cord-341968-uc8i9h0m	301	153	entry	entry	NN
cord-341968-uc8i9h0m	301	154	into	into	IN
cord-341968-uc8i9h0m	301	155	target	target	NN
cord-341968-uc8i9h0m	301	156	cells	cell	NNS
cord-341968-uc8i9h0m	301	157	TMPRSS2	TMPRSS2	NNP
cord-341968-uc8i9h0m	301	158	contributes	contribute	VBZ
cord-341968-uc8i9h0m	301	159	to	to	IN
cord-341968-uc8i9h0m	301	160	virus	virus	NN
cord-341968-uc8i9h0m	301	161	spread	spread	VB
cord-341968-uc8i9h0m	301	162	and	and	CC
cord-341968-uc8i9h0m	301	163	immunopathology	immunopathology	NN
cord-341968-uc8i9h0m	301	164	in	in	IN
cord-341968-uc8i9h0m	301	165	the	the	DT
cord-341968-uc8i9h0m	301	166	airways	airway	NNS
cord-341968-uc8i9h0m	301	167	of	of	IN
cord-341968-uc8i9h0m	301	168	murine	murine	JJ
cord-341968-uc8i9h0m	301	169	models	model	NNS
cord-341968-uc8i9h0m	301	170	after	after	IN
cord-341968-uc8i9h0m	301	171	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	301	172	infection	infection	NN
cord-341968-uc8i9h0m	301	173	Cleavage	cleavage	NN
cord-341968-uc8i9h0m	301	174	of	of	IN
cord-341968-uc8i9h0m	301	175	a	a	DT
cord-341968-uc8i9h0m	301	176	neuroinvasive	neuroinvasive	JJ
cord-341968-uc8i9h0m	301	177	human	human	JJ
cord-341968-uc8i9h0m	301	178	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	301	179	virus	virus	NN
cord-341968-uc8i9h0m	301	180	spike	spike	NN
cord-341968-uc8i9h0m	301	181	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	301	182	by	by	IN
cord-341968-uc8i9h0m	301	183	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	301	184	convertases	convertases	NNP
cord-341968-uc8i9h0m	301	185	modulates	modulate	VBZ
cord-341968-uc8i9h0m	302	1	neurovirulence	neurovirulence	NNP
cord-341968-uc8i9h0m	302	2	and	and	CC
cord-341968-uc8i9h0m	302	3	virus	virus	NN
cord-341968-uc8i9h0m	302	4	spread	spread	VBD
cord-341968-uc8i9h0m	302	5	within	within	IN
cord-341968-uc8i9h0m	302	6	the	the	DT
cord-341968-uc8i9h0m	302	7	central	central	JJ
cord-341968-uc8i9h0m	302	8	nervous	nervous	JJ
cord-341968-uc8i9h0m	302	9	system	system	NN
cord-341968-uc8i9h0m	303	1	A	a	DT
cord-341968-uc8i9h0m	303	2	single	single	JJ
cord-341968-uc8i9h0m	303	3	point	point	NN
cord-341968-uc8i9h0m	303	4	mutation	mutation	NN
cord-341968-uc8i9h0m	303	5	creating	create	VBG
cord-341968-uc8i9h0m	303	6	a	a	DT
cord-341968-uc8i9h0m	303	7	furin	furin	NN
cord-341968-uc8i9h0m	303	8	cleavage	cleavage	NN
cord-341968-uc8i9h0m	303	9	site	site	NN
cord-341968-uc8i9h0m	303	10	in	in	IN
cord-341968-uc8i9h0m	303	11	the	the	DT
cord-341968-uc8i9h0m	303	12	spike	spike	NN
cord-341968-uc8i9h0m	303	13	protein	protein	NN
cord-341968-uc8i9h0m	303	14	renders	render	VBZ
cord-341968-uc8i9h0m	303	15	porcine	porcine	JJ
cord-341968-uc8i9h0m	303	16	epidemic	epidemic	NN
cord-341968-uc8i9h0m	303	17	diarrhea	diarrhea	NN
cord-341968-uc8i9h0m	303	18	coronavirus	coronavirus	NN
cord-341968-uc8i9h0m	303	19	trypsin	trypsin	NN
cord-341968-uc8i9h0m	303	20	independent	independent	JJ
cord-341968-uc8i9h0m	303	21	for	for	IN
cord-341968-uc8i9h0m	303	22	cell	cell	NN
cord-341968-uc8i9h0m	303	23	entry	entry	NN
cord-341968-uc8i9h0m	303	24	and	and	CC
cord-341968-uc8i9h0m	303	25	fusion	fusion	NN
cord-341968-uc8i9h0m	303	26	Comparative	comparative	JJ
cord-341968-uc8i9h0m	303	27	processing	processing	NN
cord-341968-uc8i9h0m	303	28	of	of	IN
cord-341968-uc8i9h0m	303	29	bovine	bovine	JJ
cord-341968-uc8i9h0m	303	30	leukemia	leukemia	NN
cord-341968-uc8i9h0m	303	31	virus	virus	NN
cord-341968-uc8i9h0m	303	32	envelope	envelope	NN
cord-341968-uc8i9h0m	303	33	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	303	34	gp72	gp72	JJ
cord-341968-uc8i9h0m	303	35	by	by	IN
cord-341968-uc8i9h0m	303	36	subtilisin	subtilisin	NNP
cord-341968-uc8i9h0m	303	37	/	/	SYM
cord-341968-uc8i9h0m	303	38	kexin	kexin	NN
cord-341968-uc8i9h0m	303	39	-	-	HYPH
cord-341968-uc8i9h0m	303	40	like	like	JJ
cord-341968-uc8i9h0m	303	41	mammalian	mammalian	JJ
cord-341968-uc8i9h0m	303	42	convertases	convertase	NNS
cord-341968-uc8i9h0m	304	1	Furin	furin	NN
cord-341968-uc8i9h0m	304	2	cleavage	cleavage	NN
cord-341968-uc8i9h0m	304	3	potentiates	potentiate	VBZ
cord-341968-uc8i9h0m	304	4	the	the	DT
cord-341968-uc8i9h0m	304	5	membrane	membrane	NN
cord-341968-uc8i9h0m	304	6	fusion	fusion	NN
cord-341968-uc8i9h0m	304	7	-	-	HYPH
cord-341968-uc8i9h0m	304	8	controlling	control	VBG
cord-341968-uc8i9h0m	304	9	intersubunit	intersubunit	NNP
cord-341968-uc8i9h0m	304	10	disulfide	disulfide	JJ
cord-341968-uc8i9h0m	304	11	bond	bond	NN
cord-341968-uc8i9h0m	304	12	isomerization	isomerization	NN
cord-341968-uc8i9h0m	304	13	activity	activity	NN
cord-341968-uc8i9h0m	304	14	of	of	IN
cord-341968-uc8i9h0m	304	15	leukemia	leukemia	NN
cord-341968-uc8i9h0m	304	16	virus	virus	NN
cord-341968-uc8i9h0m	304	17	Env	Env	NNP
cord-341968-uc8i9h0m	304	18	Furin	Furin	NNP
cord-341968-uc8i9h0m	304	19	cleavage	cleavage	NN
cord-341968-uc8i9h0m	304	20	of	of	IN
cord-341968-uc8i9h0m	304	21	the	the	DT
cord-341968-uc8i9h0m	304	22	Moloney	Moloney	NNP
cord-341968-uc8i9h0m	304	23	murine	murine	JJ
cord-341968-uc8i9h0m	304	24	leukemia	leukemia	NN
cord-341968-uc8i9h0m	304	25	virus	virus	NN
cord-341968-uc8i9h0m	304	26	Env	Env	NNP
cord-341968-uc8i9h0m	304	27	precursor	precursor	NN
cord-341968-uc8i9h0m	304	28	reorganizes	reorganize	VBZ
cord-341968-uc8i9h0m	304	29	the	the	DT
cord-341968-uc8i9h0m	304	30	spike	spike	NN
cord-341968-uc8i9h0m	304	31	structure	structure	NN
cord-341968-uc8i9h0m	304	32	Cooperative	cooperative	JJ
cord-341968-uc8i9h0m	304	33	cleavage	cleavage	NN
cord-341968-uc8i9h0m	304	34	of	of	IN
cord-341968-uc8i9h0m	304	35	the	the	DT
cord-341968-uc8i9h0m	304	36	R	r	NN
cord-341968-uc8i9h0m	304	37	peptide	peptide	NN
cord-341968-uc8i9h0m	304	38	in	in	IN
cord-341968-uc8i9h0m	304	39	the	the	DT
cord-341968-uc8i9h0m	304	40	Env	Env	NNP
cord-341968-uc8i9h0m	304	41	trimer	trimer	NN
cord-341968-uc8i9h0m	304	42	of	of	IN
cord-341968-uc8i9h0m	304	43	Moloney	Moloney	NNP
cord-341968-uc8i9h0m	304	44	murine	murine	JJ
cord-341968-uc8i9h0m	304	45	leukemia	leukemia	NN
cord-341968-uc8i9h0m	304	46	virus	virus	NN
cord-341968-uc8i9h0m	305	1	facilitates	facilitate	VBZ
cord-341968-uc8i9h0m	305	2	its	-PRON-	PRP$
cord-341968-uc8i9h0m	305	3	maturation	maturation	NN
cord-341968-uc8i9h0m	305	4	for	for	IN
cord-341968-uc8i9h0m	305	5	fusion	fusion	NN
cord-341968-uc8i9h0m	305	6	competence	competence	NN
cord-341968-uc8i9h0m	305	7	Maturation	Maturation	NNP
cord-341968-uc8i9h0m	305	8	cleavage	cleavage	NN
cord-341968-uc8i9h0m	305	9	of	of	IN
cord-341968-uc8i9h0m	305	10	the	the	DT
cord-341968-uc8i9h0m	305	11	murine	murine	JJ
cord-341968-uc8i9h0m	305	12	leukemia	leukemia	NN
cord-341968-uc8i9h0m	305	13	virus	virus	NN
cord-341968-uc8i9h0m	305	14	Env	Env	NNP
cord-341968-uc8i9h0m	305	15	precursor	precursor	NN
cord-341968-uc8i9h0m	305	16	separates	separate	VBZ
cord-341968-uc8i9h0m	305	17	the	the	DT
cord-341968-uc8i9h0m	305	18	transmembrane	transmembrane	NN
cord-341968-uc8i9h0m	305	19	subunits	subunit	NNS
cord-341968-uc8i9h0m	305	20	to	to	TO
cord-341968-uc8i9h0m	305	21	prime	prime	VB
cord-341968-uc8i9h0m	305	22	it	-PRON-	PRP
cord-341968-uc8i9h0m	305	23	for	for	IN
cord-341968-uc8i9h0m	305	24	receptor	receptor	NN
cord-341968-uc8i9h0m	305	25	triggering	trigger	VBG
cord-341968-uc8i9h0m	305	26	Comparative	comparative	JJ
cord-341968-uc8i9h0m	305	27	cellular	cellular	JJ
cord-341968-uc8i9h0m	305	28	processing	processing	NN
cord-341968-uc8i9h0m	305	29	of	of	IN
cord-341968-uc8i9h0m	305	30	the	the	DT
cord-341968-uc8i9h0m	305	31	human	human	JJ
cord-341968-uc8i9h0m	305	32	immunodeficiency	immunodeficiency	NN
cord-341968-uc8i9h0m	305	33	virus	virus	NN
cord-341968-uc8i9h0m	305	34	(	(	-LRB-
cord-341968-uc8i9h0m	305	35	HIV-1	HIV-1	NNP
cord-341968-uc8i9h0m	305	36	)	)	-RRB-
cord-341968-uc8i9h0m	305	37	envelope	envelope	NN
cord-341968-uc8i9h0m	305	38	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	305	39	gp160	gp160	NNP
cord-341968-uc8i9h0m	305	40	by	by	IN
cord-341968-uc8i9h0m	305	41	the	the	DT
cord-341968-uc8i9h0m	305	42	mammalian	mammalian	JJ
cord-341968-uc8i9h0m	305	43	subtilisin	subtilisin	NNP
cord-341968-uc8i9h0m	305	44	/	/	SYM
cord-341968-uc8i9h0m	305	45	kexin	kexin	NN
cord-341968-uc8i9h0m	305	46	-	-	HYPH
cord-341968-uc8i9h0m	305	47	like	like	JJ
cord-341968-uc8i9h0m	305	48	convertases	convertase	NNS
cord-341968-uc8i9h0m	306	1	The	the	DT
cord-341968-uc8i9h0m	306	2	role	role	NN
cord-341968-uc8i9h0m	306	3	of	of	IN
cord-341968-uc8i9h0m	306	4	eukaryotic	eukaryotic	JJ
cord-341968-uc8i9h0m	306	5	subtilisin	subtilisin	NNP
cord-341968-uc8i9h0m	306	6	-	-	HYPH
cord-341968-uc8i9h0m	306	7	like	like	JJ
cord-341968-uc8i9h0m	306	8	endoproteases	endoprotease	NNS
cord-341968-uc8i9h0m	306	9	for	for	IN
cord-341968-uc8i9h0m	306	10	the	the	DT
cord-341968-uc8i9h0m	306	11	activation	activation	NN
cord-341968-uc8i9h0m	306	12	of	of	IN
cord-341968-uc8i9h0m	306	13	human	human	JJ
cord-341968-uc8i9h0m	306	14	immunodeficiency	immunodeficiency	NN
cord-341968-uc8i9h0m	306	15	virus	virus	NN
cord-341968-uc8i9h0m	306	16	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	306	17	in	in	IN
cord-341968-uc8i9h0m	306	18	natural	natural	JJ
cord-341968-uc8i9h0m	306	19	host	host	NN
cord-341968-uc8i9h0m	306	20	cells	cell	NNS
cord-341968-uc8i9h0m	306	21	Structure	Structure	NNP
cord-341968-uc8i9h0m	306	22	of	of	IN
cord-341968-uc8i9h0m	306	23	a	a	DT
cord-341968-uc8i9h0m	306	24	cleavage	cleavage	NN
cord-341968-uc8i9h0m	306	25	-	-	HYPH
cord-341968-uc8i9h0m	306	26	independent	independent	JJ
cord-341968-uc8i9h0m	306	27	HIV	HIV	NNP
cord-341968-uc8i9h0m	306	28	Env	Env	NNP
cord-341968-uc8i9h0m	306	29	recapitulates	recapitulate	VBZ
cord-341968-uc8i9h0m	306	30	the	the	DT
cord-341968-uc8i9h0m	306	31	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	306	32	architecture	architecture	NN
cord-341968-uc8i9h0m	306	33	of	of	IN
cord-341968-uc8i9h0m	306	34	the	the	DT
cord-341968-uc8i9h0m	306	35	native	native	JJ
cord-341968-uc8i9h0m	306	36	cleaved	cleave	VBN
cord-341968-uc8i9h0m	306	37	trimer	trimer	NN
cord-341968-uc8i9h0m	306	38	Heparin	Heparin	NNP
cord-341968-uc8i9h0m	306	39	enhances	enhance	VBZ
cord-341968-uc8i9h0m	306	40	the	the	DT
cord-341968-uc8i9h0m	306	41	furin	furin	NN
cord-341968-uc8i9h0m	306	42	cleavage	cleavage	NN
cord-341968-uc8i9h0m	306	43	of	of	IN
cord-341968-uc8i9h0m	306	44	HIV-1	HIV-1	NNP
cord-341968-uc8i9h0m	306	45	gp160	gp160	NNP
cord-341968-uc8i9h0m	306	46	peptides	peptide	NNS
cord-341968-uc8i9h0m	307	1	Initiation	initiation	NN
cord-341968-uc8i9h0m	307	2	of	of	IN
cord-341968-uc8i9h0m	307	3	duck	duck	NN
cord-341968-uc8i9h0m	307	4	hepatitis	hepatitis	NN
cord-341968-uc8i9h0m	307	5	B	B	NNP
cord-341968-uc8i9h0m	307	6	virus	virus	NN
cord-341968-uc8i9h0m	307	7	infection	infection	NN
cord-341968-uc8i9h0m	307	8	requires	require	VBZ
cord-341968-uc8i9h0m	307	9	cleavage	cleavage	NN
cord-341968-uc8i9h0m	307	10	by	by	IN
cord-341968-uc8i9h0m	307	11	a	a	DT
cord-341968-uc8i9h0m	307	12	furin	furin	NN
cord-341968-uc8i9h0m	307	13	-	-	HYPH
cord-341968-uc8i9h0m	307	14	like	like	JJ
cord-341968-uc8i9h0m	307	15	protease	protease	NN
cord-341968-uc8i9h0m	307	16	Processing	processing	NN
cord-341968-uc8i9h0m	307	17	of	of	IN
cord-341968-uc8i9h0m	307	18	the	the	DT
cord-341968-uc8i9h0m	307	19	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	307	20	virus	virus	NN
cord-341968-uc8i9h0m	307	21	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	307	22	by	by	IN
cord-341968-uc8i9h0m	307	23	the	the	DT
cord-341968-uc8i9h0m	307	24	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	307	25	convertase	convertase	NN
cord-341968-uc8i9h0m	307	26	furin	furin	VBD
cord-341968-uc8i9h0m	307	27	Biochemical	biochemical	JJ
cord-341968-uc8i9h0m	307	28	analysis	analysis	NN
cord-341968-uc8i9h0m	307	29	of	of	IN
cord-341968-uc8i9h0m	307	30	the	the	DT
cord-341968-uc8i9h0m	307	31	secreted	secrete	VBN
cord-341968-uc8i9h0m	307	32	and	and	CC
cord-341968-uc8i9h0m	307	33	virion	virion	NN
cord-341968-uc8i9h0m	307	34	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	307	35	of	of	IN
cord-341968-uc8i9h0m	307	36	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	307	37	virus	virus	NN
cord-341968-uc8i9h0m	307	38	Proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	307	39	processing	processing	NN
cord-341968-uc8i9h0m	307	40	of	of	IN
cord-341968-uc8i9h0m	307	41	Marburg	Marburg	NNP
cord-341968-uc8i9h0m	307	42	virus	virus	NN
cord-341968-uc8i9h0m	307	43	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	307	44	Endoproteolytic	endoproteolytic	JJ
cord-341968-uc8i9h0m	307	45	processing	processing	NN
cord-341968-uc8i9h0m	307	46	of	of	IN
cord-341968-uc8i9h0m	307	47	the	the	DT
cord-341968-uc8i9h0m	307	48	ebola	ebola	NNP
cord-341968-uc8i9h0m	307	49	virus	virus	NN
cord-341968-uc8i9h0m	307	50	envelope	envelope	NN
cord-341968-uc8i9h0m	307	51	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	307	52	:	:	:
cord-341968-uc8i9h0m	307	53	Cleavage	cleavage	NN
cord-341968-uc8i9h0m	307	54	is	be	VBZ
cord-341968-uc8i9h0m	307	55	not	not	RB
cord-341968-uc8i9h0m	307	56	required	require	VBN
cord-341968-uc8i9h0m	307	57	for	for	IN
cord-341968-uc8i9h0m	307	58	function	function	NN
cord-341968-uc8i9h0m	307	59	Reverse	reverse	JJ
cord-341968-uc8i9h0m	307	60	genetics	genetics	NN
cord-341968-uc8i9h0m	307	61	demonstrates	demonstrate	VBZ
cord-341968-uc8i9h0m	307	62	that	that	IN
cord-341968-uc8i9h0m	307	63	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	307	64	processing	processing	NN
cord-341968-uc8i9h0m	307	65	of	of	IN
cord-341968-uc8i9h0m	307	66	the	the	DT
cord-341968-uc8i9h0m	307	67	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	307	68	virus	virus	NN
cord-341968-uc8i9h0m	307	69	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	307	70	is	be	VBZ
cord-341968-uc8i9h0m	307	71	not	not	RB
cord-341968-uc8i9h0m	307	72	essential	essential	JJ
cord-341968-uc8i9h0m	307	73	for	for	IN
cord-341968-uc8i9h0m	307	74	replication	replication	NN
cord-341968-uc8i9h0m	307	75	in	in	IN
cord-341968-uc8i9h0m	307	76	cell	cell	NN
cord-341968-uc8i9h0m	307	77	culture	culture	NN
cord-341968-uc8i9h0m	308	1	Proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	308	2	processing	processing	NN
cord-341968-uc8i9h0m	308	3	of	of	IN
cord-341968-uc8i9h0m	308	4	the	the	DT
cord-341968-uc8i9h0m	308	5	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	308	6	virus	virus	NN
cord-341968-uc8i9h0m	308	7	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	308	8	is	be	VBZ
cord-341968-uc8i9h0m	308	9	not	not	RB
cord-341968-uc8i9h0m	308	10	critical	critical	JJ
cord-341968-uc8i9h0m	308	11	for	for	IN
cord-341968-uc8i9h0m	308	12	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	308	13	virus	virus	NN
cord-341968-uc8i9h0m	308	14	replication	replication	NN
cord-341968-uc8i9h0m	308	15	in	in	IN
cord-341968-uc8i9h0m	308	16	nonhuman	nonhuman	NN
cord-341968-uc8i9h0m	308	17	primates	primate	NNS
cord-341968-uc8i9h0m	309	1	Endosomal	Endosomal	NNP
cord-341968-uc8i9h0m	309	2	proteolysis	proteolysis	NN
cord-341968-uc8i9h0m	309	3	of	of	IN
cord-341968-uc8i9h0m	309	4	the	the	DT
cord-341968-uc8i9h0m	309	5	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	309	6	virus	virus	NN
cord-341968-uc8i9h0m	309	7	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	309	8	is	be	VBZ
cord-341968-uc8i9h0m	309	9	necessary	necessary	JJ
cord-341968-uc8i9h0m	309	10	for	for	IN
cord-341968-uc8i9h0m	309	11	infection	infection	NN
cord-341968-uc8i9h0m	309	12	Role	role	NN
cord-341968-uc8i9h0m	309	13	of	of	IN
cord-341968-uc8i9h0m	309	14	endosomal	endosomal	NNP
cord-341968-uc8i9h0m	309	15	cathepsins	cathepsin	NNS
cord-341968-uc8i9h0m	309	16	in	in	IN
cord-341968-uc8i9h0m	309	17	entry	entry	NN
cord-341968-uc8i9h0m	309	18	mediated	mediate	VBN
cord-341968-uc8i9h0m	309	19	by	by	IN
cord-341968-uc8i9h0m	309	20	the	the	DT
cord-341968-uc8i9h0m	309	21	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	309	22	virus	virus	NN
cord-341968-uc8i9h0m	309	23	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	309	24	Filoviruses	Filoviruses	NNPS
cord-341968-uc8i9h0m	309	25	require	require	VBP
cord-341968-uc8i9h0m	309	26	endosomal	endosomal	NNP
cord-341968-uc8i9h0m	309	27	cysteine	cysteine	NN
cord-341968-uc8i9h0m	309	28	proteases	protease	NNS
cord-341968-uc8i9h0m	309	29	for	for	IN
cord-341968-uc8i9h0m	309	30	entry	entry	NN
cord-341968-uc8i9h0m	309	31	but	but	CC
cord-341968-uc8i9h0m	309	32	exhibit	exhibit	VB
cord-341968-uc8i9h0m	309	33	distinct	distinct	JJ
cord-341968-uc8i9h0m	309	34	protease	protease	NN
cord-341968-uc8i9h0m	309	35	preferences	preference	NNS
cord-341968-uc8i9h0m	309	36	Proteolysis	Proteolysis	NNP
cord-341968-uc8i9h0m	309	37	of	of	IN
cord-341968-uc8i9h0m	309	38	the	the	DT
cord-341968-uc8i9h0m	309	39	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	309	40	virus	virus	NN
cord-341968-uc8i9h0m	309	41	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	309	42	enhances	enhance	VBZ
cord-341968-uc8i9h0m	309	43	virus	virus	NN
cord-341968-uc8i9h0m	309	44	binding	binding	NN
cord-341968-uc8i9h0m	309	45	and	and	CC
cord-341968-uc8i9h0m	309	46	infectivity	infectivity	NN
cord-341968-uc8i9h0m	309	47	Ebola	Ebola	NNP
cord-341968-uc8i9h0m	309	48	virus	virus	NN
cord-341968-uc8i9h0m	309	49	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	309	50	needs	need	VBZ
cord-341968-uc8i9h0m	309	51	an	an	DT
cord-341968-uc8i9h0m	309	52	additional	additional	JJ
cord-341968-uc8i9h0m	309	53	trigger	trigger	NN
cord-341968-uc8i9h0m	309	54	,	,	,
cord-341968-uc8i9h0m	309	55	beyond	beyond	IN
cord-341968-uc8i9h0m	309	56	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	309	57	priming	priming	NN
cord-341968-uc8i9h0m	309	58	for	for	IN
cord-341968-uc8i9h0m	309	59	membrane	membrane	NN
cord-341968-uc8i9h0m	309	60	fusion	fusion	NN
cord-341968-uc8i9h0m	309	61	Crimean	Crimean	NNP
cord-341968-uc8i9h0m	309	62	-	-	HYPH
cord-341968-uc8i9h0m	309	63	Congo	Congo	NNP
cord-341968-uc8i9h0m	309	64	hemorrhagic	hemorrhagic	JJ
cord-341968-uc8i9h0m	309	65	fever	fever	NN
cord-341968-uc8i9h0m	309	66	virus	virus	NN
cord-341968-uc8i9h0m	309	67	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	309	68	precursor	precursor	NN
cord-341968-uc8i9h0m	309	69	is	be	VBZ
cord-341968-uc8i9h0m	309	70	cleaved	cleave	VBN
cord-341968-uc8i9h0m	309	71	by	by	IN
cord-341968-uc8i9h0m	309	72	furin	furin	NN
cord-341968-uc8i9h0m	309	73	-	-	HYPH
cord-341968-uc8i9h0m	309	74	like	like	JJ
cord-341968-uc8i9h0m	309	75	and	and	CC
cord-341968-uc8i9h0m	309	76	SKI-1	SKI-1	NNP
cord-341968-uc8i9h0m	309	77	proteases	protease	NNS
cord-341968-uc8i9h0m	309	78	to	to	TO
cord-341968-uc8i9h0m	309	79	generate	generate	VB
cord-341968-uc8i9h0m	309	80	a	a	DT
cord-341968-uc8i9h0m	309	81	novel	novel	JJ
cord-341968-uc8i9h0m	309	82	38-kilodalton	38-kilodalton	CD
cord-341968-uc8i9h0m	309	83	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	309	84	Recovery	recovery	NN
cord-341968-uc8i9h0m	309	85	of	of	IN
cord-341968-uc8i9h0m	309	86	recombinant	recombinant	JJ
cord-341968-uc8i9h0m	309	87	Crimean	Crimean	NNP
cord-341968-uc8i9h0m	309	88	-	-	HYPH
cord-341968-uc8i9h0m	309	89	Congo	Congo	NNP
cord-341968-uc8i9h0m	309	90	hemorrhagic	hemorrhagic	JJ
cord-341968-uc8i9h0m	309	91	fever	fever	NN
cord-341968-uc8i9h0m	309	92	virus	virus	NN
cord-341968-uc8i9h0m	309	93	reveals	reveal	VBZ
cord-341968-uc8i9h0m	309	94	a	a	DT
cord-341968-uc8i9h0m	309	95	function	function	NN
cord-341968-uc8i9h0m	309	96	for	for	IN
cord-341968-uc8i9h0m	309	97	non	non	JJ
cord-341968-uc8i9h0m	309	98	-	-	JJ
cord-341968-uc8i9h0m	309	99	structural	structural	JJ
cord-341968-uc8i9h0m	309	100	glycoproteins	glycoprotein	NNS
cord-341968-uc8i9h0m	309	101	cleavage	cleavage	NN
cord-341968-uc8i9h0m	309	102	by	by	IN
cord-341968-uc8i9h0m	309	103	furin	furin	NN
cord-341968-uc8i9h0m	309	104	Antiviral	antiviral	JJ
cord-341968-uc8i9h0m	309	105	activity	activity	NN
cord-341968-uc8i9h0m	309	106	of	of	IN
cord-341968-uc8i9h0m	309	107	a	a	DT
cord-341968-uc8i9h0m	309	108	small	small	JJ
cord-341968-uc8i9h0m	309	109	-	-	HYPH
cord-341968-uc8i9h0m	309	110	molecule	molecule	NN
cord-341968-uc8i9h0m	309	111	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	309	112	of	of	IN
cord-341968-uc8i9h0m	309	113	arenavirus	arenavirus	NNP
cord-341968-uc8i9h0m	309	114	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	309	115	processing	processing	NN
cord-341968-uc8i9h0m	309	116	by	by	IN
cord-341968-uc8i9h0m	309	117	the	the	DT
cord-341968-uc8i9h0m	309	118	cellular	cellular	JJ
cord-341968-uc8i9h0m	309	119	site	site	NN
cord-341968-uc8i9h0m	309	120	1	1	CD
cord-341968-uc8i9h0m	309	121	protease	protease	NN
cord-341968-uc8i9h0m	309	122	Targeting	target	VBG
cord-341968-uc8i9h0m	309	123	the	the	DT
cord-341968-uc8i9h0m	309	124	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	309	125	processing	processing	NN
cord-341968-uc8i9h0m	309	126	of	of	IN
cord-341968-uc8i9h0m	309	127	the	the	DT
cord-341968-uc8i9h0m	309	128	viral	viral	JJ
cord-341968-uc8i9h0m	309	129	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	309	130	precursor	precursor	NN
cord-341968-uc8i9h0m	309	131	is	be	VBZ
cord-341968-uc8i9h0m	309	132	a	a	DT
cord-341968-uc8i9h0m	309	133	promising	promising	JJ
cord-341968-uc8i9h0m	309	134	novel	novel	JJ
cord-341968-uc8i9h0m	309	135	antiviral	antiviral	JJ
cord-341968-uc8i9h0m	309	136	strategy	strategy	NN
cord-341968-uc8i9h0m	309	137	against	against	IN
cord-341968-uc8i9h0m	309	138	arenaviruses	arenaviruses	FW
cord-341968-uc8i9h0m	309	139	Proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	309	140	cleavage	cleavage	NN
cord-341968-uc8i9h0m	309	141	of	of	IN
cord-341968-uc8i9h0m	309	142	wild	wild	JJ
cord-341968-uc8i9h0m	309	143	type	type	NN
cord-341968-uc8i9h0m	309	144	and	and	CC
cord-341968-uc8i9h0m	309	145	mutants	mutant	NNS
cord-341968-uc8i9h0m	309	146	of	of	IN
cord-341968-uc8i9h0m	309	147	the	the	DT
cord-341968-uc8i9h0m	309	148	F	F	NNP
cord-341968-uc8i9h0m	309	149	protein	protein	NN
cord-341968-uc8i9h0m	309	150	of	of	IN
cord-341968-uc8i9h0m	309	151	human	human	NNP
cord-341968-uc8i9h0m	309	152	parainfluenza	parainfluenza	NNP
cord-341968-uc8i9h0m	309	153	virus	virus	NNP
cord-341968-uc8i9h0m	309	154	type	type	NNP
cord-341968-uc8i9h0m	309	155	3	3	CD
cord-341968-uc8i9h0m	309	156	by	by	IN
cord-341968-uc8i9h0m	309	157	two	two	CD
cord-341968-uc8i9h0m	309	158	subtilisin	subtilisin	NNS
cord-341968-uc8i9h0m	309	159	-	-	HYPH
cord-341968-uc8i9h0m	309	160	like	like	JJ
cord-341968-uc8i9h0m	309	161	endoproteases	endoprotease	NNS
cord-341968-uc8i9h0m	309	162	,	,	,
cord-341968-uc8i9h0m	309	163	furin	furin	NN
cord-341968-uc8i9h0m	309	164	and	and	CC
cord-341968-uc8i9h0m	309	165	Kex2	Kex2	NNP
cord-341968-uc8i9h0m	309	166	Engineered	engineer	VBN
cord-341968-uc8i9h0m	310	1	serine	serine	JJ
cord-341968-uc8i9h0m	310	2	protease	protease	JJ
cord-341968-uc8i9h0m	310	3	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	310	4	prevents	prevent	VBZ
cord-341968-uc8i9h0m	310	5	furin	furin	NN
cord-341968-uc8i9h0m	310	6	-	-	HYPH
cord-341968-uc8i9h0m	310	7	catalyzed	catalyze	VBN
cord-341968-uc8i9h0m	310	8	activation	activation	NN
cord-341968-uc8i9h0m	310	9	of	of	IN
cord-341968-uc8i9h0m	310	10	the	the	DT
cord-341968-uc8i9h0m	310	11	fusion	fusion	NN
cord-341968-uc8i9h0m	310	12	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	310	13	and	and	CC
cord-341968-uc8i9h0m	310	14	production	production	NN
cord-341968-uc8i9h0m	310	15	of	of	IN
cord-341968-uc8i9h0m	310	16	infectious	infectious	JJ
cord-341968-uc8i9h0m	310	17	measles	measle	NNS
cord-341968-uc8i9h0m	310	18	virus	virus	NN
cord-341968-uc8i9h0m	311	1	The	the	DT
cord-341968-uc8i9h0m	311	2	role	role	NN
cord-341968-uc8i9h0m	311	3	of	of	IN
cord-341968-uc8i9h0m	311	4	subtilisin	subtilisin	NNP
cord-341968-uc8i9h0m	311	5	-	-	HYPH
cord-341968-uc8i9h0m	311	6	like	like	JJ
cord-341968-uc8i9h0m	311	7	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	311	8	convertases	convertases	NNP
cord-341968-uc8i9h0m	311	9	for	for	IN
cord-341968-uc8i9h0m	311	10	cleavage	cleavage	NN
cord-341968-uc8i9h0m	311	11	of	of	IN
cord-341968-uc8i9h0m	311	12	the	the	DT
cord-341968-uc8i9h0m	311	13	measles	measles	NNP
cord-341968-uc8i9h0m	311	14	virus	virus	NN
cord-341968-uc8i9h0m	311	15	fusion	fusion	NN
cord-341968-uc8i9h0m	311	16	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	311	17	in	in	IN
cord-341968-uc8i9h0m	311	18	different	different	JJ
cord-341968-uc8i9h0m	311	19	cell	cell	NN
cord-341968-uc8i9h0m	311	20	types	type	NNS
cord-341968-uc8i9h0m	312	1	Molecular	molecular	JJ
cord-341968-uc8i9h0m	312	2	characterization	characterization	NN
cord-341968-uc8i9h0m	312	3	and	and	CC
cord-341968-uc8i9h0m	312	4	complete	complete	JJ
cord-341968-uc8i9h0m	312	5	genome	genome	NN
cord-341968-uc8i9h0m	312	6	sequence	sequence	NN
cord-341968-uc8i9h0m	312	7	of	of	IN
cord-341968-uc8i9h0m	312	8	avian	avian	JJ
cord-341968-uc8i9h0m	312	9	paramyxovirus	paramyxovirus	NNP
cord-341968-uc8i9h0m	312	10	type	type	NN
cord-341968-uc8i9h0m	312	11	4	4	CD
cord-341968-uc8i9h0m	312	12	prototype	prototype	NN
cord-341968-uc8i9h0m	312	13	strain	strain	NN
cord-341968-uc8i9h0m	312	14	duck	duck	NN
cord-341968-uc8i9h0m	312	15	/	/	SYM
cord-341968-uc8i9h0m	312	16	Hong	Hong	NNP
cord-341968-uc8i9h0m	312	17	Kong	Kong	NNP
cord-341968-uc8i9h0m	313	1	/D3/75	/D3/75	:
cord-341968-uc8i9h0m	313	2	Complete	complete	JJ
cord-341968-uc8i9h0m	313	3	sequence	sequence	NN
cord-341968-uc8i9h0m	313	4	of	of	IN
cord-341968-uc8i9h0m	313	5	the	the	DT
cord-341968-uc8i9h0m	313	6	genome	genome	NN
cord-341968-uc8i9h0m	313	7	of	of	IN
cord-341968-uc8i9h0m	313	8	avian	avian	JJ
cord-341968-uc8i9h0m	313	9	paramyxovirus	paramyxovirus	NNP
cord-341968-uc8i9h0m	313	10	type	type	NN
cord-341968-uc8i9h0m	313	11	9	9	CD
cord-341968-uc8i9h0m	313	12	and	and	CC
cord-341968-uc8i9h0m	313	13	comparison	comparison	NN
cord-341968-uc8i9h0m	313	14	with	with	IN
cord-341968-uc8i9h0m	313	15	other	other	JJ
cord-341968-uc8i9h0m	313	16	paramyxoviruses	paramyxovirus	NNS
cord-341968-uc8i9h0m	313	17	Mutations	Mutations	NNPS
cord-341968-uc8i9h0m	313	18	in	in	IN
cord-341968-uc8i9h0m	313	19	the	the	DT
cord-341968-uc8i9h0m	313	20	fusion	fusion	NN
cord-341968-uc8i9h0m	313	21	protein	protein	NN
cord-341968-uc8i9h0m	313	22	cleavage	cleavage	NN
cord-341968-uc8i9h0m	313	23	site	site	NN
cord-341968-uc8i9h0m	313	24	of	of	IN
cord-341968-uc8i9h0m	313	25	avian	avian	JJ
cord-341968-uc8i9h0m	313	26	paramyxovirus	paramyxovirus	JJ
cord-341968-uc8i9h0m	313	27	serotype	serotype	NN
cord-341968-uc8i9h0m	313	28	2	2	CD
cord-341968-uc8i9h0m	313	29	increase	increase	VBP
cord-341968-uc8i9h0m	313	30	cleavability	cleavability	NN
cord-341968-uc8i9h0m	313	31	and	and	CC
cord-341968-uc8i9h0m	313	32	syncytium	syncytium	NN
cord-341968-uc8i9h0m	313	33	formation	formation	NN
cord-341968-uc8i9h0m	313	34	but	but	CC
cord-341968-uc8i9h0m	313	35	do	do	VBP
cord-341968-uc8i9h0m	313	36	not	not	RB
cord-341968-uc8i9h0m	313	37	increase	increase	VB
cord-341968-uc8i9h0m	313	38	viral	viral	JJ
cord-341968-uc8i9h0m	313	39	virulence	virulence	NN
cord-341968-uc8i9h0m	313	40	in	in	IN
cord-341968-uc8i9h0m	313	41	chickens	chicken	NNS
cord-341968-uc8i9h0m	313	42	Mutation	Mutation	NNP
cord-341968-uc8i9h0m	313	43	of	of	IN
cord-341968-uc8i9h0m	313	44	the	the	DT
cord-341968-uc8i9h0m	313	45	f	f	NNP
cord-341968-uc8i9h0m	313	46	-	-	HYPH
cord-341968-uc8i9h0m	313	47	protein	protein	NN
cord-341968-uc8i9h0m	313	48	cleavage	cleavage	NN
cord-341968-uc8i9h0m	313	49	site	site	NN
cord-341968-uc8i9h0m	313	50	of	of	IN
cord-341968-uc8i9h0m	313	51	avian	avian	JJ
cord-341968-uc8i9h0m	313	52	paramyxovirus	paramyxovirus	NNP
cord-341968-uc8i9h0m	313	53	type	type	NN
cord-341968-uc8i9h0m	313	54	7	7	CD
cord-341968-uc8i9h0m	313	55	results	result	NNS
cord-341968-uc8i9h0m	313	56	in	in	IN
cord-341968-uc8i9h0m	313	57	furin	furin	NN
cord-341968-uc8i9h0m	313	58	cleavage	cleavage	NN
cord-341968-uc8i9h0m	313	59	,	,	,
cord-341968-uc8i9h0m	313	60	fusion	fusion	NN
cord-341968-uc8i9h0m	313	61	promotion	promotion	NN
cord-341968-uc8i9h0m	313	62	,	,	,
cord-341968-uc8i9h0m	313	63	and	and	CC
cord-341968-uc8i9h0m	313	64	increased	increase	VBN
cord-341968-uc8i9h0m	313	65	replication	replication	NN
cord-341968-uc8i9h0m	313	66	in	in	IN
cord-341968-uc8i9h0m	313	67	vitro	vitro	FW
cord-341968-uc8i9h0m	313	68	but	but	CC
cord-341968-uc8i9h0m	313	69	not	not	RB
cord-341968-uc8i9h0m	313	70	increased	increase	VBN
cord-341968-uc8i9h0m	313	71	replication	replication	NN
cord-341968-uc8i9h0m	313	72	,	,	,
cord-341968-uc8i9h0m	313	73	tissue	tissue	NN
cord-341968-uc8i9h0m	313	74	tropism	tropism	NN
cord-341968-uc8i9h0m	313	75	,	,	,
cord-341968-uc8i9h0m	313	76	or	or	CC
cord-341968-uc8i9h0m	313	77	virulence	virulence	NN
cord-341968-uc8i9h0m	313	78	in	in	IN
cord-341968-uc8i9h0m	313	79	chickens	chicken	NNS
cord-341968-uc8i9h0m	313	80	Mutations	Mutations	NNPS
cord-341968-uc8i9h0m	313	81	in	in	IN
cord-341968-uc8i9h0m	313	82	the	the	DT
cord-341968-uc8i9h0m	313	83	fusion	fusion	NN
cord-341968-uc8i9h0m	313	84	protein	protein	NN
cord-341968-uc8i9h0m	313	85	cleavage	cleavage	NN
cord-341968-uc8i9h0m	313	86	site	site	NN
cord-341968-uc8i9h0m	313	87	of	of	IN
cord-341968-uc8i9h0m	313	88	avian	avian	JJ
cord-341968-uc8i9h0m	313	89	paramyxovirus	paramyxovirus	NNP
cord-341968-uc8i9h0m	313	90	serotype	serotype	NN
cord-341968-uc8i9h0m	313	91	4	4	CD
cord-341968-uc8i9h0m	313	92	confer	confer	VBP
cord-341968-uc8i9h0m	313	93	increased	increase	VBN
cord-341968-uc8i9h0m	313	94	replication	replication	NN
cord-341968-uc8i9h0m	313	95	and	and	CC
cord-341968-uc8i9h0m	313	96	syncytium	syncytium	NN
cord-341968-uc8i9h0m	313	97	formation	formation	NN
cord-341968-uc8i9h0m	313	98	in	in	IN
cord-341968-uc8i9h0m	313	99	vitro	vitro	FW
cord-341968-uc8i9h0m	313	100	but	but	CC
cord-341968-uc8i9h0m	313	101	not	not	RB
cord-341968-uc8i9h0m	313	102	increased	increase	VBN
cord-341968-uc8i9h0m	313	103	replication	replication	NN
cord-341968-uc8i9h0m	313	104	and	and	CC
cord-341968-uc8i9h0m	313	105	pathogenicity	pathogenicity	NN
cord-341968-uc8i9h0m	313	106	in	in	IN
cord-341968-uc8i9h0m	313	107	chickens	chicken	NNS
cord-341968-uc8i9h0m	313	108	and	and	CC
cord-341968-uc8i9h0m	313	109	ducks	duck	NNS
cord-341968-uc8i9h0m	313	110	Effect	effect	NN
cord-341968-uc8i9h0m	313	111	of	of	IN
cord-341968-uc8i9h0m	313	112	fusion	fusion	NN
cord-341968-uc8i9h0m	313	113	protein	protein	NN
cord-341968-uc8i9h0m	313	114	cleavage	cleavage	NN
cord-341968-uc8i9h0m	313	115	site	site	NN
cord-341968-uc8i9h0m	313	116	sequence	sequence	NN
cord-341968-uc8i9h0m	313	117	on	on	IN
cord-341968-uc8i9h0m	313	118	generation	generation	NN
cord-341968-uc8i9h0m	313	119	of	of	IN
cord-341968-uc8i9h0m	313	120	a	a	DT
cord-341968-uc8i9h0m	313	121	genotype	genotype	NN
cord-341968-uc8i9h0m	313	122	VII	VII	NNP
cord-341968-uc8i9h0m	313	123	Newcastle	Newcastle	NNP
cord-341968-uc8i9h0m	313	124	disease	disease	NN
cord-341968-uc8i9h0m	313	125	virus	virus	NN
cord-341968-uc8i9h0m	313	126	vaccine	vaccine	NN
cord-341968-uc8i9h0m	313	127	Cleavage	cleavage	NN
cord-341968-uc8i9h0m	313	128	of	of	IN
cord-341968-uc8i9h0m	313	129	the	the	DT
cord-341968-uc8i9h0m	313	130	human	human	JJ
cord-341968-uc8i9h0m	313	131	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	313	132	syncytial	syncytial	JJ
cord-341968-uc8i9h0m	313	133	virus	virus	NN
cord-341968-uc8i9h0m	313	134	fusion	fusion	NN
cord-341968-uc8i9h0m	313	135	protein	protein	NN
cord-341968-uc8i9h0m	313	136	at	at	IN
cord-341968-uc8i9h0m	313	137	two	two	CD
cord-341968-uc8i9h0m	313	138	distinct	distinct	JJ
cord-341968-uc8i9h0m	313	139	sites	site	NNS
cord-341968-uc8i9h0m	313	140	is	be	VBZ
cord-341968-uc8i9h0m	313	141	required	require	VBN
cord-341968-uc8i9h0m	313	142	for	for	IN
cord-341968-uc8i9h0m	313	143	activation	activation	NN
cord-341968-uc8i9h0m	313	144	of	of	IN
cord-341968-uc8i9h0m	313	145	membrane	membrane	NN
cord-341968-uc8i9h0m	313	146	fusion	fusion	NN
cord-341968-uc8i9h0m	313	147	Host	Host	NNP
cord-341968-uc8i9h0m	313	148	cell	cell	NN
cord-341968-uc8i9h0m	313	149	entry	entry	NN
cord-341968-uc8i9h0m	313	150	of	of	IN
cord-341968-uc8i9h0m	313	151	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	313	152	syncytial	syncytial	JJ
cord-341968-uc8i9h0m	313	153	virus	virus	NN
cord-341968-uc8i9h0m	313	154	involves	involve	VBZ
cord-341968-uc8i9h0m	313	155	macropinocytosis	macropinocytosis	NN
cord-341968-uc8i9h0m	313	156	followed	follow	VBN
cord-341968-uc8i9h0m	313	157	by	by	IN
cord-341968-uc8i9h0m	313	158	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	313	159	activation	activation	NN
cord-341968-uc8i9h0m	313	160	of	of	IN
cord-341968-uc8i9h0m	313	161	the	the	DT
cord-341968-uc8i9h0m	313	162	F	F	NNP
cord-341968-uc8i9h0m	313	163	protein	protein	NN
cord-341968-uc8i9h0m	313	164	Ubiquitous	ubiquitous	JJ
cord-341968-uc8i9h0m	313	165	activation	activation	NN
cord-341968-uc8i9h0m	313	166	of	of	IN
cord-341968-uc8i9h0m	313	167	the	the	DT
cord-341968-uc8i9h0m	313	168	Nipah	Nipah	NNP
cord-341968-uc8i9h0m	313	169	virus	virus	NN
cord-341968-uc8i9h0m	313	170	fusion	fusion	NN
cord-341968-uc8i9h0m	313	171	protein	protein	NN
cord-341968-uc8i9h0m	313	172	does	do	VBZ
cord-341968-uc8i9h0m	313	173	not	not	RB
cord-341968-uc8i9h0m	313	174	require	require	VB
cord-341968-uc8i9h0m	313	175	a	a	DT
cord-341968-uc8i9h0m	313	176	basic	basic	JJ
cord-341968-uc8i9h0m	313	177	amino	amino	NN
cord-341968-uc8i9h0m	313	178	acid	acid	NN
cord-341968-uc8i9h0m	313	179	at	at	IN
cord-341968-uc8i9h0m	313	180	the	the	DT
cord-341968-uc8i9h0m	313	181	cleavage	cleavage	NN
cord-341968-uc8i9h0m	313	182	site	site	NN
cord-341968-uc8i9h0m	313	183	Cathepsin	Cathepsin	NNP
cord-341968-uc8i9h0m	313	184	L	L	NNP
cord-341968-uc8i9h0m	313	185	is	be	VBZ
cord-341968-uc8i9h0m	313	186	involved	involve	VBN
cord-341968-uc8i9h0m	313	187	in	in	IN
cord-341968-uc8i9h0m	313	188	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	313	189	processing	processing	NN
cord-341968-uc8i9h0m	313	190	of	of	IN
cord-341968-uc8i9h0m	313	191	the	the	DT
cord-341968-uc8i9h0m	313	192	Hendra	Hendra	NNP
cord-341968-uc8i9h0m	313	193	virus	virus	NN
cord-341968-uc8i9h0m	313	194	fusion	fusion	NN
cord-341968-uc8i9h0m	313	195	protein	protein	NN
cord-341968-uc8i9h0m	313	196	Recombinant	Recombinant	NNP
cord-341968-uc8i9h0m	313	197	Sendai	Sendai	NNP
cord-341968-uc8i9h0m	313	198	viruses	virus	NNS
cord-341968-uc8i9h0m	313	199	expressing	express	VBG
cord-341968-uc8i9h0m	313	200	fusion	fusion	NN
cord-341968-uc8i9h0m	313	201	proteins	protein	NNS
cord-341968-uc8i9h0m	313	202	with	with	IN
cord-341968-uc8i9h0m	313	203	two	two	CD
cord-341968-uc8i9h0m	313	204	furin	furin	NN
cord-341968-uc8i9h0m	313	205	cleavage	cleavage	NN
cord-341968-uc8i9h0m	313	206	sites	site	NNS
cord-341968-uc8i9h0m	313	207	mimic	mimic	VBP
cord-341968-uc8i9h0m	313	208	the	the	DT
cord-341968-uc8i9h0m	313	209	syncytial	syncytial	JJ
cord-341968-uc8i9h0m	313	210	and	and	CC
cord-341968-uc8i9h0m	313	211	receptor	receptor	NN
cord-341968-uc8i9h0m	313	212	-	-	HYPH
cord-341968-uc8i9h0m	313	213	independent	independent	JJ
cord-341968-uc8i9h0m	313	214	infection	infection	NN
cord-341968-uc8i9h0m	313	215	properties	property	NNS
cord-341968-uc8i9h0m	313	216	of	of	IN
cord-341968-uc8i9h0m	313	217	respiratory	respiratory	JJ
cord-341968-uc8i9h0m	313	218	syncytial	syncytial	JJ
cord-341968-uc8i9h0m	313	219	virus	virus	NN
cord-341968-uc8i9h0m	313	220	Influenza	Influenza	NNP
cord-341968-uc8i9h0m	313	221	virus	virus	NN
cord-341968-uc8i9h0m	313	222	activating	activate	VBG
cord-341968-uc8i9h0m	313	223	host	host	NN
cord-341968-uc8i9h0m	313	224	proteases	protease	NNS
cord-341968-uc8i9h0m	313	225	:	:	:
cord-341968-uc8i9h0m	313	226	Identification	identification	NN
cord-341968-uc8i9h0m	313	227	,	,	,
cord-341968-uc8i9h0m	313	228	localization	localization	NN
cord-341968-uc8i9h0m	313	229	and	and	CC
cord-341968-uc8i9h0m	313	230	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	313	231	as	as	IN
cord-341968-uc8i9h0m	313	232	potential	potential	JJ
cord-341968-uc8i9h0m	313	233	therapeutics	therapeutic	NNS
cord-341968-uc8i9h0m	313	234	Role	role	NN
cord-341968-uc8i9h0m	313	235	of	of	IN
cord-341968-uc8i9h0m	313	236	host	host	NN
cord-341968-uc8i9h0m	313	237	cellular	cellular	JJ
cord-341968-uc8i9h0m	313	238	proteases	protease	NNS
cord-341968-uc8i9h0m	313	239	in	in	IN
cord-341968-uc8i9h0m	313	240	the	the	DT
cord-341968-uc8i9h0m	313	241	pathogenesis	pathogenesis	NN
cord-341968-uc8i9h0m	313	242	of	of	IN
cord-341968-uc8i9h0m	313	243	influenza	influenza	NN
cord-341968-uc8i9h0m	313	244	and	and	CC
cord-341968-uc8i9h0m	313	245	influenza	influenza	NN
cord-341968-uc8i9h0m	313	246	-	-	HYPH
cord-341968-uc8i9h0m	313	247	induced	induce	VBN
cord-341968-uc8i9h0m	313	248	multiple	multiple	JJ
cord-341968-uc8i9h0m	313	249	organ	organ	NN
cord-341968-uc8i9h0m	313	250	failure	failure	NN
cord-341968-uc8i9h0m	313	251	Proteolytic	Proteolytic	NNP
cord-341968-uc8i9h0m	313	252	activation	activation	NN
cord-341968-uc8i9h0m	313	253	of	of	IN
cord-341968-uc8i9h0m	313	254	the	the	DT
cord-341968-uc8i9h0m	313	255	1918	1918	CD
cord-341968-uc8i9h0m	313	256	influenza	influenza	NN
cord-341968-uc8i9h0m	313	257	virus	virus	NN
cord-341968-uc8i9h0m	313	258	hemagglutinin	hemagglutinin	VBN
cord-341968-uc8i9h0m	313	259	Proteolytic	Proteolytic	NNP
cord-341968-uc8i9h0m	313	260	activation	activation	NN
cord-341968-uc8i9h0m	313	261	of	of	IN
cord-341968-uc8i9h0m	313	262	influenza	influenza	NN
cord-341968-uc8i9h0m	313	263	viruses	virus	NNS
cord-341968-uc8i9h0m	313	264	by	by	IN
cord-341968-uc8i9h0m	313	265	serine	serine	NN
cord-341968-uc8i9h0m	313	266	proteases	protease	NNS
cord-341968-uc8i9h0m	313	267	TMPRSS2	TMPRSS2	NNP
cord-341968-uc8i9h0m	313	268	and	and	CC
cord-341968-uc8i9h0m	313	269	HAT	HAT	NNP
cord-341968-uc8i9h0m	313	270	from	from	IN
cord-341968-uc8i9h0m	313	271	human	human	JJ
cord-341968-uc8i9h0m	313	272	airway	airway	NN
cord-341968-uc8i9h0m	313	273	epithelium	epithelium	NN
cord-341968-uc8i9h0m	313	274	HAT	hat	NN
cord-341968-uc8i9h0m	313	275	,	,	,
cord-341968-uc8i9h0m	313	276	and	and	CC
cord-341968-uc8i9h0m	313	277	TMPRSS2	TMPRSS2	NNP
cord-341968-uc8i9h0m	313	278	activate	activate	VBP
cord-341968-uc8i9h0m	313	279	the	the	DT
cord-341968-uc8i9h0m	313	280	hemagglutinin	hemagglutinin	NN
cord-341968-uc8i9h0m	313	281	of	of	IN
cord-341968-uc8i9h0m	313	282	H9N2	H9N2	NNP
cord-341968-uc8i9h0m	313	283	influenza	influenza	NN
cord-341968-uc8i9h0m	313	284	A	a	DT
cord-341968-uc8i9h0m	313	285	viruses	virus	NNS
cord-341968-uc8i9h0m	314	1	A	a	DT
cord-341968-uc8i9h0m	314	2	novel	novel	JJ
cord-341968-uc8i9h0m	314	3	activation	activation	NN
cord-341968-uc8i9h0m	314	4	mechanism	mechanism	NN
cord-341968-uc8i9h0m	314	5	of	of	IN
cord-341968-uc8i9h0m	314	6	avian	avian	JJ
cord-341968-uc8i9h0m	314	7	influenza	influenza	NN
cord-341968-uc8i9h0m	314	8	virus	virus	NN
cord-341968-uc8i9h0m	314	9	H9N2	H9N2	NNP
cord-341968-uc8i9h0m	314	10	by	by	IN
cord-341968-uc8i9h0m	314	11	furin	furin	NN
cord-341968-uc8i9h0m	314	12	Influenza	Influenza	NNP
cord-341968-uc8i9h0m	314	13	virus	virus	NN
cord-341968-uc8i9h0m	314	14	hemagglutinin	hemagglutinin	NN
cord-341968-uc8i9h0m	314	15	with	with	IN
cord-341968-uc8i9h0m	314	16	multibasic	multibasic	NNP
cord-341968-uc8i9h0m	314	17	cleavage	cleavage	NN
cord-341968-uc8i9h0m	314	18	site	site	NN
cord-341968-uc8i9h0m	314	19	is	be	VBZ
cord-341968-uc8i9h0m	314	20	activated	activate	VBN
cord-341968-uc8i9h0m	314	21	by	by	IN
cord-341968-uc8i9h0m	314	22	furin	furin	NN
cord-341968-uc8i9h0m	314	23	,	,	,
cord-341968-uc8i9h0m	314	24	a	a	DT
cord-341968-uc8i9h0m	314	25	subtilisin	subtilisin	NN
cord-341968-uc8i9h0m	314	26	-	-	HYPH
cord-341968-uc8i9h0m	314	27	like	like	JJ
cord-341968-uc8i9h0m	314	28	endoprotease	endoprotease	NNP
cord-341968-uc8i9h0m	314	29	Proprotein	Proprotein	NNP
cord-341968-uc8i9h0m	314	30	-	-	HYPH
cord-341968-uc8i9h0m	314	31	processing	process	VBG
cord-341968-uc8i9h0m	314	32	endoproteases	endoprotease	NNS
cord-341968-uc8i9h0m	314	33	PC6	PC6	NNP
cord-341968-uc8i9h0m	314	34	and	and	CC
cord-341968-uc8i9h0m	314	35	furin	furin	NN
cord-341968-uc8i9h0m	314	36	both	both	DT
cord-341968-uc8i9h0m	314	37	activate	activate	VBP
cord-341968-uc8i9h0m	314	38	hemagglutinin	hemagglutinin	NN
cord-341968-uc8i9h0m	314	39	of	of	IN
cord-341968-uc8i9h0m	314	40	virulent	virulent	JJ
cord-341968-uc8i9h0m	314	41	avian	avian	JJ
cord-341968-uc8i9h0m	314	42	influenza	influenza	NN
cord-341968-uc8i9h0m	314	43	viruses	virus	NNS
cord-341968-uc8i9h0m	314	44	Sequence	sequence	NN
cord-341968-uc8i9h0m	314	45	specificity	specificity	NN
cord-341968-uc8i9h0m	314	46	of	of	IN
cord-341968-uc8i9h0m	314	47	furin	furin	NN
cord-341968-uc8i9h0m	314	48	,	,	,
cord-341968-uc8i9h0m	314	49	a	a	DT
cord-341968-uc8i9h0m	314	50	proprotein	proprotein	NN
cord-341968-uc8i9h0m	314	51	-	-	HYPH
cord-341968-uc8i9h0m	314	52	processing	processing	NN
cord-341968-uc8i9h0m	314	53	endoprotease	endoprotease	NN
cord-341968-uc8i9h0m	314	54	,	,	,
cord-341968-uc8i9h0m	314	55	for	for	IN
cord-341968-uc8i9h0m	314	56	the	the	DT
cord-341968-uc8i9h0m	314	57	hemagglutinin	hemagglutinin	NN
cord-341968-uc8i9h0m	314	58	of	of	IN
cord-341968-uc8i9h0m	314	59	a	a	DT
cord-341968-uc8i9h0m	314	60	virulent	virulent	JJ
cord-341968-uc8i9h0m	314	61	avian	avian	JJ
cord-341968-uc8i9h0m	314	62	influenza	influenza	NN
cord-341968-uc8i9h0m	314	63	virus	virus	NN
cord-341968-uc8i9h0m	314	64	Activation	activation	NN
cord-341968-uc8i9h0m	314	65	of	of	IN
cord-341968-uc8i9h0m	314	66	an	an	DT
cord-341968-uc8i9h0m	314	67	influenza	influenza	NN
cord-341968-uc8i9h0m	314	68	virus	virus	NN
cord-341968-uc8i9h0m	314	69	A	A	NNP
cord-341968-uc8i9h0m	314	70	/	/	SYM
cord-341968-uc8i9h0m	314	71	turkey	turkey	NNP
cord-341968-uc8i9h0m	314	72	/	/	SYM
cord-341968-uc8i9h0m	314	73	Oregon/71	Oregon/71	NNP
cord-341968-uc8i9h0m	314	74	HA	HA	NNP
cord-341968-uc8i9h0m	314	75	insertion	insertion	NN
cord-341968-uc8i9h0m	314	76	variant	variant	NN
cord-341968-uc8i9h0m	314	77	by	by	IN
cord-341968-uc8i9h0m	314	78	the	the	DT
cord-341968-uc8i9h0m	314	79	subtilisin	subtilisin	NNP
cord-341968-uc8i9h0m	314	80	-	-	HYPH
cord-341968-uc8i9h0m	314	81	like	like	JJ
cord-341968-uc8i9h0m	314	82	endoprotease	endoprotease	NN
cord-341968-uc8i9h0m	314	83	furin	furin	NN
cord-341968-uc8i9h0m	314	84	Targeted	target	VBN
cord-341968-uc8i9h0m	314	85	infection	infection	NN
cord-341968-uc8i9h0m	314	86	of	of	IN
cord-341968-uc8i9h0m	314	87	endothelial	endothelial	JJ
cord-341968-uc8i9h0m	314	88	cells	cell	NNS
cord-341968-uc8i9h0m	314	89	by	by	IN
cord-341968-uc8i9h0m	314	90	avian	avian	JJ
cord-341968-uc8i9h0m	314	91	influenza	influenza	NN
cord-341968-uc8i9h0m	314	92	virus	virus	NN
cord-341968-uc8i9h0m	314	93	A	A	NNP
cord-341968-uc8i9h0m	314	94	/	/	SYM
cord-341968-uc8i9h0m	314	95	FPV	FPV	NNP
cord-341968-uc8i9h0m	314	96	/	/	SYM
cord-341968-uc8i9h0m	314	97	Rostock/34	rostock/34	CD
cord-341968-uc8i9h0m	314	98	(	(	-LRB-
cord-341968-uc8i9h0m	314	99	H7N1	H7N1	NNP
cord-341968-uc8i9h0m	314	100	)	)	-RRB-
cord-341968-uc8i9h0m	314	101	in	in	IN
cord-341968-uc8i9h0m	314	102	chicken	chicken	NN
cord-341968-uc8i9h0m	314	103	embryos	embryo	NNS
cord-341968-uc8i9h0m	314	104	Molecular	molecular	JJ
cord-341968-uc8i9h0m	314	105	basis	basis	NN
cord-341968-uc8i9h0m	314	106	for	for	IN
cord-341968-uc8i9h0m	314	107	high	high	JJ
cord-341968-uc8i9h0m	314	108	virulence	virulence	NN
cord-341968-uc8i9h0m	314	109	of	of	IN
cord-341968-uc8i9h0m	314	110	Hong	Hong	NNP
cord-341968-uc8i9h0m	314	111	Kong	Kong	NNP
cord-341968-uc8i9h0m	314	112	H5N1	H5N1	NNP
cord-341968-uc8i9h0m	315	1	influenza	influenza	NN
cord-341968-uc8i9h0m	315	2	A	a	DT
cord-341968-uc8i9h0m	315	3	viruses	virus	NNS
cord-341968-uc8i9h0m	316	1	Novel	novel	NN
cord-341968-uc8i9h0m	316	2	type	type	NN
cord-341968-uc8i9h0m	316	3	II	II	NNP
cord-341968-uc8i9h0m	316	4	transmembrane	transmembrane	NN
cord-341968-uc8i9h0m	316	5	serine	serine	NN
cord-341968-uc8i9h0m	316	6	proteases	protease	NNS
cord-341968-uc8i9h0m	316	7	,	,	,
cord-341968-uc8i9h0m	316	8	MSPL	MSPL	NNP
cord-341968-uc8i9h0m	316	9	and	and	CC
cord-341968-uc8i9h0m	316	10	TMPRSS13	TMPRSS13	NNP
cord-341968-uc8i9h0m	316	11	,	,	,
cord-341968-uc8i9h0m	316	12	Proteolytically	Proteolytically	NNP
cord-341968-uc8i9h0m	316	13	activate	activate	VBP
cord-341968-uc8i9h0m	316	14	membrane	membrane	NN
cord-341968-uc8i9h0m	316	15	fusion	fusion	NN
cord-341968-uc8i9h0m	316	16	activity	activity	NN
cord-341968-uc8i9h0m	316	17	of	of	IN
cord-341968-uc8i9h0m	316	18	the	the	DT
cord-341968-uc8i9h0m	316	19	hemagglutinin	hemagglutinin	NN
cord-341968-uc8i9h0m	316	20	of	of	IN
cord-341968-uc8i9h0m	316	21	highly	highly	RB
cord-341968-uc8i9h0m	316	22	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	316	23	avian	avian	JJ
cord-341968-uc8i9h0m	316	24	influenza	influenza	NN
cord-341968-uc8i9h0m	316	25	viruses	virus	NNS
cord-341968-uc8i9h0m	316	26	and	and	CC
cord-341968-uc8i9h0m	316	27	induce	induce	VB
cord-341968-uc8i9h0m	316	28	their	-PRON-	PRP$
cord-341968-uc8i9h0m	316	29	multicycle	multicycle	NN
cord-341968-uc8i9h0m	316	30	replication	replication	NN
cord-341968-uc8i9h0m	316	31	Furin	Furin	NNP
cord-341968-uc8i9h0m	316	32	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	316	33	:	:	:
cord-341968-uc8i9h0m	317	1	Importance	importance	NN
cord-341968-uc8i9h0m	317	2	of	of	IN
cord-341968-uc8i9h0m	317	3	the	the	DT
cord-341968-uc8i9h0m	317	4	positive	positive	JJ
cord-341968-uc8i9h0m	317	5	formal	formal	JJ
cord-341968-uc8i9h0m	317	6	charge	charge	NN
cord-341968-uc8i9h0m	317	7	and	and	CC
cord-341968-uc8i9h0m	317	8	beyond	beyond	IN
cord-341968-uc8i9h0m	317	9	A	a	DT
cord-341968-uc8i9h0m	317	10	small	small	JJ
cord-341968-uc8i9h0m	317	11	-	-	HYPH
cord-341968-uc8i9h0m	317	12	molecule	molecule	NN
cord-341968-uc8i9h0m	317	13	furin	furin	NN
cord-341968-uc8i9h0m	317	14	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	317	15	inhibits	inhibit	VBZ
cord-341968-uc8i9h0m	317	16	cancer	cancer	NN
cord-341968-uc8i9h0m	317	17	cell	cell	NN
cord-341968-uc8i9h0m	317	18	motility	motility	NN
cord-341968-uc8i9h0m	317	19	and	and	CC
cord-341968-uc8i9h0m	317	20	invasiveness	invasiveness	NN
cord-341968-uc8i9h0m	317	21	Inhibition	inhibition	NN
cord-341968-uc8i9h0m	317	22	of	of	IN
cord-341968-uc8i9h0m	317	23	furin	furin	NN
cord-341968-uc8i9h0m	317	24	/	/	SYM
cord-341968-uc8i9h0m	317	25	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	317	26	convertase	convertase	NN
cord-341968-uc8i9h0m	317	27	-	-	HYPH
cord-341968-uc8i9h0m	317	28	catalyzed	catalyze	VBN
cord-341968-uc8i9h0m	317	29	surface	surface	NN
cord-341968-uc8i9h0m	317	30	and	and	CC
cord-341968-uc8i9h0m	317	31	intracellular	intracellular	JJ
cord-341968-uc8i9h0m	317	32	processing	processing	NN
cord-341968-uc8i9h0m	317	33	by	by	IN
cord-341968-uc8i9h0m	317	34	small	small	JJ
cord-341968-uc8i9h0m	317	35	molecules	molecule	NNS
cord-341968-uc8i9h0m	318	1	Synthetic	synthetic	JJ
cord-341968-uc8i9h0m	318	2	small	small	JJ
cord-341968-uc8i9h0m	318	3	molecule	molecule	NN
cord-341968-uc8i9h0m	318	4	furin	furin	NN
cord-341968-uc8i9h0m	318	5	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	318	6	derived	derive	VBN
cord-341968-uc8i9h0m	318	7	from	from	IN
cord-341968-uc8i9h0m	318	8	2,5-dideoxystreptamine	2,5-dideoxystreptamine	CD
cord-341968-uc8i9h0m	318	9	Identification	identification	NN
cord-341968-uc8i9h0m	318	10	of	of	IN
cord-341968-uc8i9h0m	318	11	potent	potent	JJ
cord-341968-uc8i9h0m	318	12	and	and	CC
cord-341968-uc8i9h0m	318	13	compartment	compartment	NN
cord-341968-uc8i9h0m	318	14	-	-	HYPH
cord-341968-uc8i9h0m	318	15	selective	selective	JJ
cord-341968-uc8i9h0m	318	16	small	small	JJ
cord-341968-uc8i9h0m	318	17	molecule	molecule	NN
cord-341968-uc8i9h0m	318	18	furin	furin	NN
cord-341968-uc8i9h0m	318	19	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	318	20	using	use	VBG
cord-341968-uc8i9h0m	318	21	cell	cell	NN
cord-341968-uc8i9h0m	318	22	-	-	HYPH
cord-341968-uc8i9h0m	318	23	based	base	VBN
cord-341968-uc8i9h0m	318	24	assays	assay	NNS
cord-341968-uc8i9h0m	318	25	Potent	potent	JJ
cord-341968-uc8i9h0m	318	26	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	318	27	of	of	IN
cord-341968-uc8i9h0m	318	28	furin	furin	NN
cord-341968-uc8i9h0m	318	29	and	and	CC
cord-341968-uc8i9h0m	318	30	furin	furin	NN
cord-341968-uc8i9h0m	318	31	-	-	HYPH
cord-341968-uc8i9h0m	318	32	like	like	IN
cord-341968-uc8i9h0m	318	33	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	318	34	convertases	convertases	NNP
cord-341968-uc8i9h0m	318	35	containing	contain	VBG
cord-341968-uc8i9h0m	318	36	decarboxylated	decarboxylate	VBN
cord-341968-uc8i9h0m	318	37	P1	P1	NNP
cord-341968-uc8i9h0m	318	38	arginine	arginine	NN
cord-341968-uc8i9h0m	318	39	mimetics	mimetic	NNS
cord-341968-uc8i9h0m	319	1	The	the	DT
cord-341968-uc8i9h0m	319	2	Multi	Multi	NNP
cord-341968-uc8i9h0m	319	3	-	-	NNP
cord-341968-uc8i9h0m	319	4	Leu	Leu	NNP
cord-341968-uc8i9h0m	319	5	peptide	peptide	JJ
cord-341968-uc8i9h0m	319	6	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	319	7	discriminates	discriminate	VBZ
cord-341968-uc8i9h0m	319	8	between	between	IN
cord-341968-uc8i9h0m	319	9	PACE4	pace4	CD
cord-341968-uc8i9h0m	319	10	and	and	CC
cord-341968-uc8i9h0m	319	11	furin	furin	NN
cord-341968-uc8i9h0m	319	12	and	and	CC
cord-341968-uc8i9h0m	319	13	exhibits	exhibit	VBZ
cord-341968-uc8i9h0m	319	14	antiproliferative	antiproliferative	JJ
cord-341968-uc8i9h0m	319	15	effects	effect	NNS
cord-341968-uc8i9h0m	319	16	on	on	IN
cord-341968-uc8i9h0m	319	17	prostate	prostate	NN
cord-341968-uc8i9h0m	319	18	cancer	cancer	NN
cord-341968-uc8i9h0m	319	19	cells	cell	NNS
cord-341968-uc8i9h0m	319	20	Targeting	target	VBG
cord-341968-uc8i9h0m	319	21	host	host	NN
cord-341968-uc8i9h0m	319	22	cell	cell	NN
cord-341968-uc8i9h0m	319	23	furin	furin	NN
cord-341968-uc8i9h0m	319	24	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	319	25	convertases	convertases	NNP
cord-341968-uc8i9h0m	319	26	as	as	IN
cord-341968-uc8i9h0m	319	27	a	a	DT
cord-341968-uc8i9h0m	319	28	therapeutic	therapeutic	JJ
cord-341968-uc8i9h0m	319	29	strategy	strategy	NN
cord-341968-uc8i9h0m	319	30	against	against	IN
cord-341968-uc8i9h0m	319	31	bacterial	bacterial	JJ
cord-341968-uc8i9h0m	319	32	toxins	toxin	NNS
cord-341968-uc8i9h0m	319	33	and	and	CC
cord-341968-uc8i9h0m	319	34	viral	viral	JJ
cord-341968-uc8i9h0m	319	35	pathogens	pathogen	NNS
cord-341968-uc8i9h0m	320	1	A	a	DT
cord-341968-uc8i9h0m	320	2	novel	novel	NN
cord-341968-uc8i9h0m	320	3	enediynyl	enediynyl	NN
cord-341968-uc8i9h0m	320	4	peptide	peptide	JJ
cord-341968-uc8i9h0m	320	5	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	320	6	of	of	IN
cord-341968-uc8i9h0m	320	7	furin	furin	NN
cord-341968-uc8i9h0m	320	8	that	that	WDT
cord-341968-uc8i9h0m	320	9	blocks	block	VBZ
cord-341968-uc8i9h0m	320	10	processing	processing	NN
cord-341968-uc8i9h0m	320	11	of	of	IN
cord-341968-uc8i9h0m	320	12	proPDGF	propdgf	NN
cord-341968-uc8i9h0m	321	1	-A	-A	:
cord-341968-uc8i9h0m	321	2	Selective	selective	JJ
cord-341968-uc8i9h0m	321	3	and	and	CC
cord-341968-uc8i9h0m	321	4	potent	potent	JJ
cord-341968-uc8i9h0m	321	5	furin	furin	NN
cord-341968-uc8i9h0m	321	6	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	321	7	protect	protect	VBP
cord-341968-uc8i9h0m	321	8	cells	cell	NNS
cord-341968-uc8i9h0m	321	9	from	from	IN
cord-341968-uc8i9h0m	321	10	anthrax	anthrax	NN
cord-341968-uc8i9h0m	321	11	without	without	IN
cord-341968-uc8i9h0m	321	12	significant	significant	JJ
cord-341968-uc8i9h0m	321	13	toxicity	toxicity	NN
cord-341968-uc8i9h0m	321	14	Highly	highly	RB
cord-341968-uc8i9h0m	321	15	potent	potent	JJ
cord-341968-uc8i9h0m	321	16	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	321	17	of	of	IN
cord-341968-uc8i9h0m	321	18	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	321	19	convertase	convertase	NNP
cord-341968-uc8i9h0m	321	20	furin	furin	NN
cord-341968-uc8i9h0m	321	21	as	as	IN
cord-341968-uc8i9h0m	321	22	potential	potential	JJ
cord-341968-uc8i9h0m	321	23	drugs	drug	NNS
cord-341968-uc8i9h0m	321	24	for	for	IN
cord-341968-uc8i9h0m	321	25	treatment	treatment	NN
cord-341968-uc8i9h0m	321	26	of	of	IN
cord-341968-uc8i9h0m	321	27	infectious	infectious	JJ
cord-341968-uc8i9h0m	321	28	diseases	disease	NNS
cord-341968-uc8i9h0m	321	29	Optimization	Optimization	NNP
cord-341968-uc8i9h0m	321	30	of	of	IN
cord-341968-uc8i9h0m	321	31	furin	furin	NN
cord-341968-uc8i9h0m	321	32	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	321	33	to	to	TO
cord-341968-uc8i9h0m	321	34	protect	protect	VB
cord-341968-uc8i9h0m	321	35	against	against	IN
cord-341968-uc8i9h0m	321	36	the	the	DT
cord-341968-uc8i9h0m	321	37	activation	activation	NN
cord-341968-uc8i9h0m	321	38	of	of	IN
cord-341968-uc8i9h0m	321	39	influenza	influenza	NN
cord-341968-uc8i9h0m	321	40	hemagglutinin	hemagglutinin	NN
cord-341968-uc8i9h0m	321	41	H5	H5	NNP
cord-341968-uc8i9h0m	321	42	and	and	CC
cord-341968-uc8i9h0m	321	43	Shiga	Shiga	NNP
cord-341968-uc8i9h0m	321	44	toxin	toxin	NN
cord-341968-uc8i9h0m	321	45	Design	design	NN
cord-341968-uc8i9h0m	321	46	,	,	,
cord-341968-uc8i9h0m	321	47	synthesis	synthesis	NN
cord-341968-uc8i9h0m	321	48	,	,	,
cord-341968-uc8i9h0m	321	49	and	and	CC
cord-341968-uc8i9h0m	321	50	structure−activity	structure−activity	CD
cord-341968-uc8i9h0m	321	51	relationship	relationship	NN
cord-341968-uc8i9h0m	321	52	studies	study	NNS
cord-341968-uc8i9h0m	321	53	of	of	IN
cord-341968-uc8i9h0m	321	54	a	a	DT
cord-341968-uc8i9h0m	321	55	potent	potent	JJ
cord-341968-uc8i9h0m	321	56	PACE4	pace4	CD
cord-341968-uc8i9h0m	321	57	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	321	58	Peptidomimetic	Peptidomimetic	NNP
cord-341968-uc8i9h0m	321	59	furin	furin	NN
cord-341968-uc8i9h0m	321	60	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	321	61	MI-701	mi-701	XX
cord-341968-uc8i9h0m	321	62	in	in	IN
cord-341968-uc8i9h0m	321	63	combination	combination	NN
cord-341968-uc8i9h0m	321	64	with	with	IN
cord-341968-uc8i9h0m	321	65	oseltamivir	oseltamivir	NN
cord-341968-uc8i9h0m	321	66	and	and	CC
cord-341968-uc8i9h0m	321	67	ribavirin	ribavirin	NN
cord-341968-uc8i9h0m	321	68	efficiently	efficiently	RB
cord-341968-uc8i9h0m	321	69	blocks	block	VBZ
cord-341968-uc8i9h0m	321	70	propagation	propagation	NN
cord-341968-uc8i9h0m	321	71	of	of	IN
cord-341968-uc8i9h0m	321	72	highly	highly	RB
cord-341968-uc8i9h0m	321	73	pathogenic	pathogenic	JJ
cord-341968-uc8i9h0m	321	74	avian	avian	JJ
cord-341968-uc8i9h0m	321	75	influenza	influenza	NN
cord-341968-uc8i9h0m	321	76	viruses	virus	NNS
cord-341968-uc8i9h0m	321	77	and	and	CC
cord-341968-uc8i9h0m	321	78	delays	delay	NNS
cord-341968-uc8i9h0m	321	79	high	high	JJ
cord-341968-uc8i9h0m	321	80	level	level	NN
cord-341968-uc8i9h0m	321	81	oseltamivir	oseltamivir	FW
cord-341968-uc8i9h0m	321	82	resistance	resistance	NN
cord-341968-uc8i9h0m	321	83	in	in	IN
cord-341968-uc8i9h0m	321	84	MDCK	MDCK	NNP
cord-341968-uc8i9h0m	321	85	cells	cell	NNS
cord-341968-uc8i9h0m	322	1	Novel	novel	NN
cord-341968-uc8i9h0m	322	2	furin	furin	NN
cord-341968-uc8i9h0m	322	3	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	322	4	with	with	IN
cord-341968-uc8i9h0m	322	5	potent	potent	JJ
cord-341968-uc8i9h0m	322	6	anti	anti	JJ
cord-341968-uc8i9h0m	322	7	-	-	JJ
cord-341968-uc8i9h0m	322	8	infectious	infectious	JJ
cord-341968-uc8i9h0m	322	9	activity	activity	NN
cord-341968-uc8i9h0m	322	10	Optimization	optimization	NN
cord-341968-uc8i9h0m	322	11	of	of	IN
cord-341968-uc8i9h0m	322	12	substrate	substrate	NN
cord-341968-uc8i9h0m	322	13	-	-	HYPH
cord-341968-uc8i9h0m	322	14	analogue	analogue	NN
cord-341968-uc8i9h0m	322	15	furin	furin	NN
cord-341968-uc8i9h0m	322	16	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	322	17	Elongated	elongate	VBD
cord-341968-uc8i9h0m	322	18	and	and	CC
cord-341968-uc8i9h0m	322	19	shortened	shorten	VBN
cord-341968-uc8i9h0m	322	20	peptidomimetic	peptidomimetic	JJ
cord-341968-uc8i9h0m	322	21	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	322	22	of	of	IN
cord-341968-uc8i9h0m	322	23	the	the	DT
cord-341968-uc8i9h0m	322	24	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	322	25	convertase	convertase	NN
cord-341968-uc8i9h0m	322	26	furin	furin	NN
cord-341968-uc8i9h0m	322	27	Effects	effect	NNS
cord-341968-uc8i9h0m	322	28	of	of	IN
cord-341968-uc8i9h0m	322	29	NS2B	NS2B	NNP
cord-341968-uc8i9h0m	322	30	-	-	:
cord-341968-uc8i9h0m	322	31	NS3	ns3	RB
cord-341968-uc8i9h0m	322	32	protease	protease	NN
cord-341968-uc8i9h0m	322	33	and	and	CC
cord-341968-uc8i9h0m	322	34	furin	furin	NN
cord-341968-uc8i9h0m	322	35	inhibition	inhibition	NN
cord-341968-uc8i9h0m	322	36	on	on	IN
cord-341968-uc8i9h0m	322	37	West	West	NNP
cord-341968-uc8i9h0m	322	38	Nile	Nile	NNP
cord-341968-uc8i9h0m	322	39	and	and	CC
cord-341968-uc8i9h0m	322	40	Dengue	Dengue	NNP
cord-341968-uc8i9h0m	322	41	virus	virus	NN
cord-341968-uc8i9h0m	322	42	replication	replication	NN
cord-341968-uc8i9h0m	322	43	Design	design	NN
cord-341968-uc8i9h0m	322	44	,	,	,
cord-341968-uc8i9h0m	322	45	synthesis	synthesis	NN
cord-341968-uc8i9h0m	322	46	,	,	,
cord-341968-uc8i9h0m	322	47	and	and	CC
cord-341968-uc8i9h0m	322	48	characterization	characterization	NN
cord-341968-uc8i9h0m	322	49	of	of	IN
cord-341968-uc8i9h0m	322	50	macrocyclic	macrocyclic	NNP
cord-341968-uc8i9h0m	322	51	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	322	52	of	of	IN
cord-341968-uc8i9h0m	322	53	the	the	DT
cord-341968-uc8i9h0m	322	54	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	322	55	convertase	convertase	NN
cord-341968-uc8i9h0m	322	56	furin	furin	NN
cord-341968-uc8i9h0m	322	57	Polyarginines	Polyarginines	NNP
cord-341968-uc8i9h0m	322	58	are	be	VBP
cord-341968-uc8i9h0m	322	59	potent	potent	JJ
cord-341968-uc8i9h0m	322	60	furin	furin	NN
cord-341968-uc8i9h0m	322	61	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	323	1	Short	short	JJ
cord-341968-uc8i9h0m	323	2	polybasic	polybasic	JJ
cord-341968-uc8i9h0m	323	3	peptide	peptide	NN
cord-341968-uc8i9h0m	323	4	sequences	sequence	NNS
cord-341968-uc8i9h0m	323	5	are	be	VBP
cord-341968-uc8i9h0m	323	6	potent	potent	JJ
cord-341968-uc8i9h0m	323	7	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	323	8	of	of	IN
cord-341968-uc8i9h0m	323	9	PC5/6	pc5/6	JJ
cord-341968-uc8i9h0m	323	10	and	and	CC
cord-341968-uc8i9h0m	323	11	PC7	PC7	NNS
cord-341968-uc8i9h0m	323	12	:	:	:
cord-341968-uc8i9h0m	323	13	Use	use	NN
cord-341968-uc8i9h0m	323	14	of	of	IN
cord-341968-uc8i9h0m	323	15	positional	positional	JJ
cord-341968-uc8i9h0m	323	16	scanning	scanning	NN
cord-341968-uc8i9h0m	323	17	-	-	HYPH
cord-341968-uc8i9h0m	323	18	synthetic	synthetic	JJ
cord-341968-uc8i9h0m	323	19	peptide	peptide	JJ
cord-341968-uc8i9h0m	323	20	combinatorial	combinatorial	JJ
cord-341968-uc8i9h0m	323	21	libraries	library	NNS
cord-341968-uc8i9h0m	323	22	as	as	IN
cord-341968-uc8i9h0m	323	23	a	a	DT
cord-341968-uc8i9h0m	323	24	tool	tool	NN
cord-341968-uc8i9h0m	323	25	for	for	IN
cord-341968-uc8i9h0m	323	26	the	the	DT
cord-341968-uc8i9h0m	323	27	optimization	optimization	NN
cord-341968-uc8i9h0m	323	28	of	of	IN
cord-341968-uc8i9h0m	323	29	inhibitory	inhibitory	JJ
cord-341968-uc8i9h0m	323	30	sequences	sequence	NNS
cord-341968-uc8i9h0m	323	31	Lindberg	Lindberg	NNP
cord-341968-uc8i9h0m	323	32	,	,	,
cord-341968-uc8i9h0m	323	33	I.	I.	NNP
cord-341968-uc8i9h0m	323	34	Cationic	Cationic	NNP
cord-341968-uc8i9h0m	323	35	cell	cell	NN
cord-341968-uc8i9h0m	323	36	-	-	HYPH
cord-341968-uc8i9h0m	323	37	penetrating	penetrate	VBG
cord-341968-uc8i9h0m	323	38	peptides	peptide	NNS
cord-341968-uc8i9h0m	323	39	are	be	VBP
cord-341968-uc8i9h0m	323	40	potent	potent	JJ
cord-341968-uc8i9h0m	323	41	furin	furin	NN
cord-341968-uc8i9h0m	323	42	inhibitors	inhibitor	NNS
cord-341968-uc8i9h0m	324	1	Engineered	engineer	VBN
cord-341968-uc8i9h0m	324	2	eglin	eglin	NNP
cord-341968-uc8i9h0m	324	3	c	c	NNP
cord-341968-uc8i9h0m	324	4	variants	variant	NNS
cord-341968-uc8i9h0m	324	5	inhibit	inhibit	VBP
cord-341968-uc8i9h0m	324	6	yeast	yeast	NN
cord-341968-uc8i9h0m	324	7	and	and	CC
cord-341968-uc8i9h0m	324	8	human	human	JJ
cord-341968-uc8i9h0m	324	9	proprotein	proprotein	NNP
cord-341968-uc8i9h0m	324	10	processing	processing	NN
cord-341968-uc8i9h0m	324	11	proteases	protease	NNS
cord-341968-uc8i9h0m	324	12	,	,	,
cord-341968-uc8i9h0m	324	13	Kex2	Kex2	NNP
cord-341968-uc8i9h0m	324	14	and	and	CC
cord-341968-uc8i9h0m	324	15	furin	furin	NN
cord-341968-uc8i9h0m	324	16	Arg15-Lys17-Arg18	arg15-lys17-arg18	CD
cord-341968-uc8i9h0m	324	17	turkey	turkey	NN
cord-341968-uc8i9h0m	325	1	ovomucoid	ovomucoid	NNP
cord-341968-uc8i9h0m	326	1	third	third	JJ
cord-341968-uc8i9h0m	326	2	domain	domain	NN
cord-341968-uc8i9h0m	326	3	inhibits	inhibit	VBZ
cord-341968-uc8i9h0m	326	4	human	human	JJ
cord-341968-uc8i9h0m	326	5	furin	furin	NN
cord-341968-uc8i9h0m	326	6	Inhibition	inhibition	NN
cord-341968-uc8i9h0m	326	7	of	of	IN
cord-341968-uc8i9h0m	326	8	intracellular	intracellular	JJ
cord-341968-uc8i9h0m	326	9	proteolytic	proteolytic	JJ
cord-341968-uc8i9h0m	326	10	processing	processing	NN
cord-341968-uc8i9h0m	326	11	of	of	IN
cord-341968-uc8i9h0m	326	12	soluble	soluble	JJ
cord-341968-uc8i9h0m	326	13	proproteins	proprotein	NNS
cord-341968-uc8i9h0m	326	14	by	by	IN
cord-341968-uc8i9h0m	326	15	an	an	DT
cord-341968-uc8i9h0m	326	16	engineered	engineer	VBN
cord-341968-uc8i9h0m	326	17	α2-macroglobulin	α2-macroglobulin	''
cord-341968-uc8i9h0m	326	18	containing	contain	VBG
cord-341968-uc8i9h0m	326	19	a	a	DT
cord-341968-uc8i9h0m	326	20	furin	furin	NN
cord-341968-uc8i9h0m	326	21	recognition	recognition	NN
cord-341968-uc8i9h0m	326	22	sequence	sequence	NN
cord-341968-uc8i9h0m	326	23	in	in	IN
cord-341968-uc8i9h0m	326	24	the	the	DT
cord-341968-uc8i9h0m	326	25	bait	bait	NN
cord-341968-uc8i9h0m	326	26	region	region	NN
cord-341968-uc8i9h0m	327	1	Polyarginine	Polyarginine	NNP
cord-341968-uc8i9h0m	327	2	inhibits	inhibit	VBZ
cord-341968-uc8i9h0m	327	3	gp160	gp160	NNP
cord-341968-uc8i9h0m	327	4	processing	processing	NN
cord-341968-uc8i9h0m	327	5	by	by	IN
cord-341968-uc8i9h0m	327	6	furin	furin	NN
cord-341968-uc8i9h0m	327	7	and	and	CC
cord-341968-uc8i9h0m	327	8	suppresses	suppress	VBZ
cord-341968-uc8i9h0m	327	9	productive	productive	JJ
cord-341968-uc8i9h0m	327	10	human	human	JJ
cord-341968-uc8i9h0m	327	11	immunodeficiency	immunodeficiency	NN
cord-341968-uc8i9h0m	327	12	virus	virus	NN
cord-341968-uc8i9h0m	327	13	type	type	NN
cord-341968-uc8i9h0m	327	14	1	1	CD
cord-341968-uc8i9h0m	327	15	infection	infection	NN
cord-341968-uc8i9h0m	327	16	Blockage	blockage	NN
cord-341968-uc8i9h0m	327	17	of	of	IN
cord-341968-uc8i9h0m	327	18	filoviral	filoviral	JJ
cord-341968-uc8i9h0m	327	19	glycoprotein	glycoprotein	NN
cord-341968-uc8i9h0m	327	20	processing	processing	NN
cord-341968-uc8i9h0m	327	21	by	by	IN
cord-341968-uc8i9h0m	327	22	use	use	NN
cord-341968-uc8i9h0m	327	23	of	of	IN
cord-341968-uc8i9h0m	327	24	a	a	DT
cord-341968-uc8i9h0m	327	25	protein	protein	NN
cord-341968-uc8i9h0m	327	26	-	-	HYPH
cord-341968-uc8i9h0m	327	27	based	base	VBN
cord-341968-uc8i9h0m	327	28	inhibitor	inhibitor	NN
cord-341968-uc8i9h0m	327	29	A	a	DT
cord-341968-uc8i9h0m	327	30	protein	protein	NN
cord-341968-uc8i9h0m	327	31	-	-	HYPH
cord-341968-uc8i9h0m	327	32	based	base	VBN
cord-341968-uc8i9h0m	327	33	therapeutic	therapeutic	JJ
cord-341968-uc8i9h0m	327	34	for	for	IN
cord-341968-uc8i9h0m	327	35	human	human	JJ
cord-341968-uc8i9h0m	327	36	cytomegalovirus	cytomegalovirus	NN
cord-341968-uc8i9h0m	327	37	infection	infection	NN