id sid tid token lemma pos cord-321150-ev6acl7b 1 1 key key NN cord-321150-ev6acl7b 1 2 : : : cord-321150-ev6acl7b 1 3 cord-321150-ev6acl7b cord-321150-ev6acl7b . cord-321150-ev6acl7b 2 1 authors author NNS cord-321150-ev6acl7b 2 2 : : : cord-321150-ev6acl7b 3 1 Lam Lam NNP cord-321150-ev6acl7b 3 2 , , , cord-321150-ev6acl7b 3 3 Ha Ha NNP cord-321150-ev6acl7b 3 4 Minh Minh NNP cord-321150-ev6acl7b 3 5 ; ; : cord-321150-ev6acl7b 3 6 Ratmann Ratmann NNP cord-321150-ev6acl7b 3 7 , , , cord-321150-ev6acl7b 3 8 Oliver Oliver NNP cord-321150-ev6acl7b 3 9 ; ; : cord-321150-ev6acl7b 3 10 Boni Boni NNP cord-321150-ev6acl7b 3 11 , , , cord-321150-ev6acl7b 3 12 Maciej Maciej NNP cord-321150-ev6acl7b 3 13 F F NNP cord-321150-ev6acl7b 3 14 title title NN cord-321150-ev6acl7b 3 15 : : : cord-321150-ev6acl7b 3 16 Improved Improved NNP cord-321150-ev6acl7b 3 17 Algorithmic Algorithmic NNP cord-321150-ev6acl7b 3 18 Complexity Complexity NNP cord-321150-ev6acl7b 3 19 for for IN cord-321150-ev6acl7b 3 20 the the DT cord-321150-ev6acl7b 3 21 3SEQ 3SEQ NNP cord-321150-ev6acl7b 3 22 Recombination Recombination NNP cord-321150-ev6acl7b 3 23 Detection Detection NNP cord-321150-ev6acl7b 3 24 Algorithm Algorithm NNP cord-321150-ev6acl7b 3 25 date date NN cord-321150-ev6acl7b 3 26 : : : cord-321150-ev6acl7b 3 27 2017 2017 CD cord-321150-ev6acl7b 3 28 - - SYM cord-321150-ev6acl7b 3 29 10 10 CD cord-321150-ev6acl7b 3 30 - - HYPH cord-321150-ev6acl7b 3 31 03 03 CD cord-321150-ev6acl7b 3 32 journal journal NN cord-321150-ev6acl7b 3 33 : : : cord-321150-ev6acl7b 4 1 Mol Mol NNP cord-321150-ev6acl7b 4 2 Biol Biol NNP cord-321150-ev6acl7b 4 3 Evol Evol NNP cord-321150-ev6acl7b 4 4 DOI DOI NNP cord-321150-ev6acl7b 4 5 : : : cord-321150-ev6acl7b 4 6 10.1093 10.1093 CD cord-321150-ev6acl7b 4 7 / / SYM cord-321150-ev6acl7b 4 8 molbev molbev NN cord-321150-ev6acl7b 4 9 / / SYM cord-321150-ev6acl7b 4 10 msx263 msx263 NNP cord-321150-ev6acl7b 4 11 sha sha NNP cord-321150-ev6acl7b 4 12 : : : cord-321150-ev6acl7b 4 13 517698251b94fac6d80edcc4644e2448a4efd4ef 517698251b94fac6d80edcc4644e2448a4efd4ef NNP cord-321150-ev6acl7b 4 14 doc_id doc_id CD cord-321150-ev6acl7b 4 15 : : : cord-321150-ev6acl7b 4 16 321150 321150 CD cord-321150-ev6acl7b 4 17 cord_uid cord_uid NNS cord-321150-ev6acl7b 4 18 : : : cord-321150-ev6acl7b 4 19 ev6acl7b ev6acl7b JJ cord-321150-ev6acl7b 5 1 Identifying identify VBG cord-321150-ev6acl7b 5 2 recombinant recombinant JJ cord-321150-ev6acl7b 5 3 sequences sequence NNS cord-321150-ev6acl7b 5 4 in in IN cord-321150-ev6acl7b 5 5 an an DT cord-321150-ev6acl7b 5 6 era era NN cord-321150-ev6acl7b 5 7 of of IN cord-321150-ev6acl7b 5 8 large large JJ cord-321150-ev6acl7b 5 9 genomic genomic JJ cord-321150-ev6acl7b 5 10 databases database NNS cord-321150-ev6acl7b 5 11 is be VBZ cord-321150-ev6acl7b 5 12 challenging challenging JJ cord-321150-ev6acl7b 5 13 as as IN cord-321150-ev6acl7b 5 14 it -PRON- PRP cord-321150-ev6acl7b 5 15 requires require VBZ cord-321150-ev6acl7b 5 16 an an DT cord-321150-ev6acl7b 5 17 efficient efficient JJ cord-321150-ev6acl7b 5 18 algorithm algorithm NN cord-321150-ev6acl7b 5 19 to to TO cord-321150-ev6acl7b 5 20 identify identify VB cord-321150-ev6acl7b 5 21 candidate candidate NN cord-321150-ev6acl7b 5 22 recombinants recombinant NNS cord-321150-ev6acl7b 5 23 and and CC cord-321150-ev6acl7b 5 24 parents parent NNS cord-321150-ev6acl7b 5 25 , , , cord-321150-ev6acl7b 5 26 as as RB cord-321150-ev6acl7b 5 27 well well RB cord-321150-ev6acl7b 5 28 as as IN cord-321150-ev6acl7b 5 29 appropriate appropriate JJ cord-321150-ev6acl7b 5 30 statistical statistical JJ cord-321150-ev6acl7b 5 31 methods method NNS cord-321150-ev6acl7b 5 32 to to TO cord-321150-ev6acl7b 5 33 correct correct VB cord-321150-ev6acl7b 5 34 for for IN cord-321150-ev6acl7b 5 35 the the DT cord-321150-ev6acl7b 5 36 large large JJ cord-321150-ev6acl7b 5 37 number number NN cord-321150-ev6acl7b 5 38 of of IN cord-321150-ev6acl7b 5 39 comparisons comparison NNS cord-321150-ev6acl7b 5 40 performed perform VBN cord-321150-ev6acl7b 5 41 . . . cord-321150-ev6acl7b 6 1 In in IN cord-321150-ev6acl7b 6 2 2007 2007 CD cord-321150-ev6acl7b 6 3 , , , cord-321150-ev6acl7b 6 4 a a DT cord-321150-ev6acl7b 6 5 computation computation NN cord-321150-ev6acl7b 6 6 was be VBD cord-321150-ev6acl7b 6 7 introduced introduce VBN cord-321150-ev6acl7b 6 8 for for IN cord-321150-ev6acl7b 6 9 an an DT cord-321150-ev6acl7b 6 10 exact exact JJ cord-321150-ev6acl7b 6 11 nonparametric nonparametric JJ cord-321150-ev6acl7b 6 12 mosaicism mosaicism NN cord-321150-ev6acl7b 6 13 statistic statistic NN cord-321150-ev6acl7b 6 14 that that WDT cord-321150-ev6acl7b 6 15 gave give VBD cord-321150-ev6acl7b 6 16 high high JJ cord-321150-ev6acl7b 6 17 - - HYPH cord-321150-ev6acl7b 6 18 precision precision NN cord-321150-ev6acl7b 6 19 P p NN cord-321150-ev6acl7b 6 20 values value NNS cord-321150-ev6acl7b 6 21 for for IN cord-321150-ev6acl7b 6 22 putative putative JJ cord-321150-ev6acl7b 6 23 recombinants recombinant NNS cord-321150-ev6acl7b 6 24 . . . cord-321150-ev6acl7b 7 1 This this DT cord-321150-ev6acl7b 7 2 exact exact JJ cord-321150-ev6acl7b 7 3 computation computation NN cord-321150-ev6acl7b 7 4 meant mean VBD cord-321150-ev6acl7b 7 5 that that IN cord-321150-ev6acl7b 7 6 multiple multiple JJ cord-321150-ev6acl7b 7 7 - - HYPH cord-321150-ev6acl7b 7 8 comparisons comparison NNS cord-321150-ev6acl7b 7 9 corrected correct VBD cord-321150-ev6acl7b 7 10 P p NN cord-321150-ev6acl7b 7 11 values value NNS cord-321150-ev6acl7b 7 12 also also RB cord-321150-ev6acl7b 7 13 had have VBD cord-321150-ev6acl7b 7 14 high high JJ cord-321150-ev6acl7b 7 15 precision precision NN cord-321150-ev6acl7b 7 16 , , , cord-321150-ev6acl7b 7 17 which which WDT cord-321150-ev6acl7b 7 18 is be VBZ cord-321150-ev6acl7b 7 19 crucial crucial JJ cord-321150-ev6acl7b 7 20 when when WRB cord-321150-ev6acl7b 7 21 performing perform VBG cord-321150-ev6acl7b 7 22 millions million NNS cord-321150-ev6acl7b 7 23 or or CC cord-321150-ev6acl7b 7 24 billions billion NNS cord-321150-ev6acl7b 7 25 of of IN cord-321150-ev6acl7b 7 26 tests test NNS cord-321150-ev6acl7b 7 27 in in IN cord-321150-ev6acl7b 7 28 large large JJ cord-321150-ev6acl7b 7 29 databases database NNS cord-321150-ev6acl7b 7 30 . . . cord-321150-ev6acl7b 8 1 Here here RB cord-321150-ev6acl7b 8 2 , , , cord-321150-ev6acl7b 8 3 we -PRON- PRP cord-321150-ev6acl7b 8 4 introduce introduce VBP cord-321150-ev6acl7b 8 5 an an DT cord-321150-ev6acl7b 8 6 improvement improvement NN cord-321150-ev6acl7b 8 7 to to IN cord-321150-ev6acl7b 8 8 the the DT cord-321150-ev6acl7b 8 9 algorithmic algorithmic JJ cord-321150-ev6acl7b 8 10 complexity complexity NN cord-321150-ev6acl7b 8 11 of of IN cord-321150-ev6acl7b 8 12 this this DT cord-321150-ev6acl7b 8 13 computation computation NN cord-321150-ev6acl7b 8 14 from from IN cord-321150-ev6acl7b 8 15 O(mn(3 O(mn(3 NNP cord-321150-ev6acl7b 8 16 ) ) -RRB- cord-321150-ev6acl7b 8 17 ) ) -RRB- cord-321150-ev6acl7b 8 18 to to IN cord-321150-ev6acl7b 8 19 O(mn(2 O(mn(2 NNP cord-321150-ev6acl7b 8 20 ) ) -RRB- cord-321150-ev6acl7b 8 21 ) ) -RRB- cord-321150-ev6acl7b 8 22 , , , cord-321150-ev6acl7b 8 23 where where WRB cord-321150-ev6acl7b 8 24 m m NNP cord-321150-ev6acl7b 8 25 and and CC cord-321150-ev6acl7b 8 26 n n NNP cord-321150-ev6acl7b 8 27 are be VBP cord-321150-ev6acl7b 8 28 the the DT cord-321150-ev6acl7b 8 29 numbers number NNS cord-321150-ev6acl7b 8 30 of of IN cord-321150-ev6acl7b 8 31 recombination recombination NN cord-321150-ev6acl7b 8 32 - - HYPH cord-321150-ev6acl7b 8 33 informative informative JJ cord-321150-ev6acl7b 8 34 sites site NNS cord-321150-ev6acl7b 8 35 in in IN cord-321150-ev6acl7b 8 36 the the DT cord-321150-ev6acl7b 8 37 candidate candidate NN cord-321150-ev6acl7b 8 38 recombinant recombinant JJ cord-321150-ev6acl7b 8 39 . . . cord-321150-ev6acl7b 9 1 This this DT cord-321150-ev6acl7b 9 2 new new JJ cord-321150-ev6acl7b 9 3 computation computation NN cord-321150-ev6acl7b 9 4 allows allow VBZ cord-321150-ev6acl7b 9 5 for for IN cord-321150-ev6acl7b 9 6 recombination recombination NN cord-321150-ev6acl7b 9 7 analysis analysis NN cord-321150-ev6acl7b 9 8 to to TO cord-321150-ev6acl7b 9 9 be be VB cord-321150-ev6acl7b 9 10 performed perform VBN cord-321150-ev6acl7b 9 11 in in IN cord-321150-ev6acl7b 9 12 alignments alignment NNS cord-321150-ev6acl7b 9 13 with with IN cord-321150-ev6acl7b 9 14 thousands thousand NNS cord-321150-ev6acl7b 9 15 of of IN cord-321150-ev6acl7b 9 16 polymorphic polymorphic JJ cord-321150-ev6acl7b 9 17 sites site NNS cord-321150-ev6acl7b 9 18 . . . cord-321150-ev6acl7b 10 1 Benchmark benchmark NN cord-321150-ev6acl7b 10 2 runs run NNS cord-321150-ev6acl7b 10 3 are be VBP cord-321150-ev6acl7b 10 4 presented present VBN cord-321150-ev6acl7b 10 5 on on IN cord-321150-ev6acl7b 10 6 viral viral JJ cord-321150-ev6acl7b 10 7 genome genome NN cord-321150-ev6acl7b 10 8 sequence sequence NN cord-321150-ev6acl7b 10 9 alignments alignment NNS cord-321150-ev6acl7b 10 10 , , , cord-321150-ev6acl7b 10 11 new new JJ cord-321150-ev6acl7b 10 12 features feature NNS cord-321150-ev6acl7b 10 13 are be VBP cord-321150-ev6acl7b 10 14 introduced introduce VBN cord-321150-ev6acl7b 10 15 , , , cord-321150-ev6acl7b 10 16 and and CC cord-321150-ev6acl7b 10 17 applications application NNS cord-321150-ev6acl7b 10 18 outside outside IN cord-321150-ev6acl7b 10 19 recombination recombination NN cord-321150-ev6acl7b 10 20 analysis analysis NN cord-321150-ev6acl7b 10 21 are be VBP cord-321150-ev6acl7b 10 22 discussed discuss VBN cord-321150-ev6acl7b 10 23 . . . cord-321150-ev6acl7b 11 1 Determining determine VBG cord-321150-ev6acl7b 11 2 whether whether IN cord-321150-ev6acl7b 11 3 genomic genomic JJ cord-321150-ev6acl7b 11 4 regions region NNS cord-321150-ev6acl7b 11 5 are be VBP cord-321150-ev6acl7b 11 6 undergoing undergo VBG cord-321150-ev6acl7b 11 7 homologous homologous JJ cord-321150-ev6acl7b 11 8 recombination recombination NN cord-321150-ev6acl7b 11 9 is be VBZ cord-321150-ev6acl7b 11 10 important important JJ cord-321150-ev6acl7b 11 11 in in IN cord-321150-ev6acl7b 11 12 all all DT cord-321150-ev6acl7b 11 13 parts part NNS cord-321150-ev6acl7b 11 14 of of IN cord-321150-ev6acl7b 11 15 biology biology NN cord-321150-ev6acl7b 11 16 and and CC cord-321150-ev6acl7b 11 17 genetics genetic NNS cord-321150-ev6acl7b 11 18 . . . cord-321150-ev6acl7b 12 1 Indeed indeed RB cord-321150-ev6acl7b 12 2 , , , cord-321150-ev6acl7b 12 3 recombination recombination NN cord-321150-ev6acl7b 12 4 has have VBZ cord-321150-ev6acl7b 12 5 profound profound JJ cord-321150-ev6acl7b 12 6 consequences consequence NNS cord-321150-ev6acl7b 12 7 for for IN cord-321150-ev6acl7b 12 8 a a DT cord-321150-ev6acl7b 12 9 population population NN cord-321150-ev6acl7b 12 10 's 's POS cord-321150-ev6acl7b 12 11 evolutionary evolutionary JJ cord-321150-ev6acl7b 12 12 trajectory trajectory NN cord-321150-ev6acl7b 12 13 , , , cord-321150-ev6acl7b 12 14 and and CC cord-321150-ev6acl7b 12 15 it -PRON- PRP cord-321150-ev6acl7b 12 16 changes change VBZ cord-321150-ev6acl7b 12 17 our -PRON- PRP$ cord-321150-ev6acl7b 12 18 understanding understanding NN cord-321150-ev6acl7b 12 19 of of IN cord-321150-ev6acl7b 12 20 the the DT cord-321150-ev6acl7b 12 21 evolutionary evolutionary JJ cord-321150-ev6acl7b 12 22 history history NN cord-321150-ev6acl7b 12 23 of of IN cord-321150-ev6acl7b 12 24 a a DT cord-321150-ev6acl7b 12 25 population population NN cord-321150-ev6acl7b 12 26 as as IN cord-321150-ev6acl7b 12 27 described describe VBN cord-321150-ev6acl7b 12 28 through through IN cord-321150-ev6acl7b 12 29 phylogenetics phylogenetic NNS cord-321150-ev6acl7b 12 30 ( ( -LRB- cord-321150-ev6acl7b 12 31 Schierup Schierup NNP cord-321150-ev6acl7b 12 32 and and CC cord-321150-ev6acl7b 12 33 Hein Hein NNP cord-321150-ev6acl7b 12 34 2000 2000 CD cord-321150-ev6acl7b 12 35 ; ; : cord-321150-ev6acl7b 12 36 . . . cord-321150-ev6acl7b 13 1 Identifying identify VBG cord-321150-ev6acl7b 13 2 recombination recombination NN cord-321150-ev6acl7b 13 3 is be VBZ cord-321150-ev6acl7b 13 4 especially especially RB cord-321150-ev6acl7b 13 5 important important JJ cord-321150-ev6acl7b 13 6 in in IN cord-321150-ev6acl7b 13 7 large large JJ cord-321150-ev6acl7b 13 8 genomic genomic JJ cord-321150-ev6acl7b 13 9 analyses analysis NNS cord-321150-ev6acl7b 13 10 , , , cord-321150-ev6acl7b 13 11 as as IN cord-321150-ev6acl7b 13 12 the the DT cord-321150-ev6acl7b 13 13 larger large JJR cord-321150-ev6acl7b 13 14 the the DT cord-321150-ev6acl7b 13 15 region region NN cord-321150-ev6acl7b 13 16 being be VBG cord-321150-ev6acl7b 13 17 analyzed analyze VBN cord-321150-ev6acl7b 13 18 the the DT cord-321150-ev6acl7b 13 19 higher high JJR cord-321150-ev6acl7b 13 20 the the DT cord-321150-ev6acl7b 13 21 chance chance NN cord-321150-ev6acl7b 13 22 that that IN cord-321150-ev6acl7b 13 23 recombination recombination NN cord-321150-ev6acl7b 13 24 will will MD cord-321150-ev6acl7b 13 25 be be VB cord-321150-ev6acl7b 13 26 detected detect VBN cord-321150-ev6acl7b 13 27 even even RB cord-321150-ev6acl7b 13 28 in in IN cord-321150-ev6acl7b 13 29 a a DT cord-321150-ev6acl7b 13 30 small small JJ cord-321150-ev6acl7b 13 31 sample sample NN cord-321150-ev6acl7b 13 32 . . . cord-321150-ev6acl7b 14 1 Over over IN cord-321150-ev6acl7b 14 2 the the DT cord-321150-ev6acl7b 14 3 past past JJ cord-321150-ev6acl7b 14 4 three three CD cord-321150-ev6acl7b 14 5 decades decade NNS cord-321150-ev6acl7b 14 6 , , , cord-321150-ev6acl7b 14 7 methods method NNS cord-321150-ev6acl7b 14 8 of of IN cord-321150-ev6acl7b 14 9 identifying identify VBG cord-321150-ev6acl7b 14 10 recombination recombination NN cord-321150-ev6acl7b 14 11 from from IN cord-321150-ev6acl7b 14 12 sequence sequence NN cord-321150-ev6acl7b 14 13 data datum NNS cord-321150-ev6acl7b 14 14 have have VBP cord-321150-ev6acl7b 14 15 focused focus VBN cord-321150-ev6acl7b 14 16 on on IN cord-321150-ev6acl7b 14 17 detection detection NN cord-321150-ev6acl7b 14 18 of of IN cord-321150-ev6acl7b 14 19 clustered clustered JJ cord-321150-ev6acl7b 14 20 polymorphism polymorphism NN cord-321150-ev6acl7b 14 21 , , , cord-321150-ev6acl7b 14 22 excessive excessive JJ cord-321150-ev6acl7b 14 23 homoplasy homoplasy NN cord-321150-ev6acl7b 14 24 , , , cord-321150-ev6acl7b 14 25 low low JJ cord-321150-ev6acl7b 14 26 linkage linkage NN cord-321150-ev6acl7b 14 27 disequilibrium disequilibrium NN cord-321150-ev6acl7b 14 28 , , , cord-321150-ev6acl7b 14 29 mosaicism mosaicism NN cord-321150-ev6acl7b 14 30 , , , cord-321150-ev6acl7b 14 31 and and CC cord-321150-ev6acl7b 14 32 incongruent incongruent JJ cord-321150-ev6acl7b 14 33 phylogenies phylogeny NNS cord-321150-ev6acl7b 14 34 . . . cord-321150-ev6acl7b 15 1 Some some DT cord-321150-ev6acl7b 15 2 of of IN cord-321150-ev6acl7b 15 3 these these DT cord-321150-ev6acl7b 15 4 statistical statistical JJ cord-321150-ev6acl7b 15 5 signals signal NNS cord-321150-ev6acl7b 15 6 have have VBP cord-321150-ev6acl7b 15 7 advantages advantage NNS cord-321150-ev6acl7b 15 8 over over IN cord-321150-ev6acl7b 15 9 others other NNS cord-321150-ev6acl7b 15 10 in in IN cord-321150-ev6acl7b 15 11 terms term NNS cord-321150-ev6acl7b 15 12 of of IN cord-321150-ev6acl7b 15 13 false false JJ cord-321150-ev6acl7b 15 14 positive positive JJ cord-321150-ev6acl7b 15 15 rate rate NN cord-321150-ev6acl7b 15 16 , , , cord-321150-ev6acl7b 15 17 statistical statistical JJ cord-321150-ev6acl7b 15 18 power power NN cord-321150-ev6acl7b 15 19 , , , cord-321150-ev6acl7b 15 20 speed speed NN cord-321150-ev6acl7b 15 21 , , , cord-321150-ev6acl7b 15 22 and and CC cord-321150-ev6acl7b 15 23 the the DT cord-321150-ev6acl7b 15 24 size size NN cord-321150-ev6acl7b 15 25 of of IN cord-321150-ev6acl7b 15 26 the the DT cord-321150-ev6acl7b 15 27 data datum NNS cord-321150-ev6acl7b 15 28 set set NN cord-321150-ev6acl7b 15 29 that that WDT cord-321150-ev6acl7b 15 30 can can MD cord-321150-ev6acl7b 15 31 be be VB cord-321150-ev6acl7b 15 32 analyzed analyze VBN cord-321150-ev6acl7b 15 33 . . . cord-321150-ev6acl7b 16 1 An an DT cord-321150-ev6acl7b 16 2 analysis analysis NN cord-321150-ev6acl7b 16 3 of of IN cord-321150-ev6acl7b 16 4 sensitivity sensitivity NN cord-321150-ev6acl7b 16 5 and and CC cord-321150-ev6acl7b 16 6 specificity specificity NN cord-321150-ev6acl7b 16 7 can can MD cord-321150-ev6acl7b 16 8 be be VB cord-321150-ev6acl7b 16 9 found find VBN cord-321150-ev6acl7b 16 10 in in IN cord-321150-ev6acl7b 16 11 Posada Posada NNP cord-321150-ev6acl7b 16 12 and and CC cord-321150-ev6acl7b 16 13 Crandall Crandall NNP cord-321150-ev6acl7b 16 14 ( ( -LRB- cord-321150-ev6acl7b 16 15 Posada Posada NNP cord-321150-ev6acl7b 16 16 and and CC cord-321150-ev6acl7b 16 17 Crandall Crandall NNP cord-321150-ev6acl7b 16 18 2001 2001 CD cord-321150-ev6acl7b 16 19 ) ) -RRB- cord-321150-ev6acl7b 16 20 and and CC cord-321150-ev6acl7b 16 21 a a DT cord-321150-ev6acl7b 16 22 guide guide NN cord-321150-ev6acl7b 16 23 to to IN cord-321150-ev6acl7b 16 24 choosing choose VBG cord-321150-ev6acl7b 16 25 an an DT cord-321150-ev6acl7b 16 26 appropriate appropriate JJ cord-321150-ev6acl7b 16 27 method method NN cord-321150-ev6acl7b 16 28 for for IN cord-321150-ev6acl7b 16 29 a a DT cord-321150-ev6acl7b 16 30 given give VBN cord-321150-ev6acl7b 16 31 data data NN cord-321150-ev6acl7b 16 32 set set NN cord-321150-ev6acl7b 16 33 can can MD cord-321150-ev6acl7b 16 34 be be VB cord-321150-ev6acl7b 16 35 found find VBN cord-321150-ev6acl7b 16 36 in in IN cord-321150-ev6acl7b 16 37 Martin Martin NNP cord-321150-ev6acl7b 16 38 et et NNP cord-321150-ev6acl7b 16 39 al al NNP cord-321150-ev6acl7b 16 40 . . . cord-321150-ev6acl7b 17 1 ( ( -LRB- cord-321150-ev6acl7b 17 2 2011 2011 CD cord-321150-ev6acl7b 17 3 ) ) -RRB- cord-321150-ev6acl7b 17 4 . . . cord-321150-ev6acl7b 18 1 In in IN cord-321150-ev6acl7b 18 2 modern modern JJ cord-321150-ev6acl7b 18 3 sequence sequence NN cord-321150-ev6acl7b 18 4 analysis analysis NN cord-321150-ev6acl7b 18 5 , , , cord-321150-ev6acl7b 18 6 a a DT cord-321150-ev6acl7b 18 7 major major JJ cord-321150-ev6acl7b 18 8 challenge challenge NN cord-321150-ev6acl7b 18 9 in in IN cord-321150-ev6acl7b 18 10 recombination recombination NN cord-321150-ev6acl7b 18 11 detection detection NN cord-321150-ev6acl7b 18 12 is be VBZ cord-321150-ev6acl7b 18 13 the the DT cord-321150-ev6acl7b 18 14 size size NN cord-321150-ev6acl7b 18 15 of of IN cord-321150-ev6acl7b 18 16 the the DT cord-321150-ev6acl7b 18 17 data data NN cord-321150-ev6acl7b 18 18 sets set VBZ cord-321150-ev6acl7b 18 19 themselves -PRON- PRP cord-321150-ev6acl7b 18 20 . . . cord-321150-ev6acl7b 19 1 Beyond beyond IN cord-321150-ev6acl7b 19 2 the the DT cord-321150-ev6acl7b 19 3 computational computational JJ cord-321150-ev6acl7b 19 4 burden burden NN cord-321150-ev6acl7b 19 5 , , , cord-321150-ev6acl7b 19 6 critical critical JJ cord-321150-ev6acl7b 19 7 but but CC cord-321150-ev6acl7b 19 8 often often RB cord-321150-ev6acl7b 19 9 underappreciated underappreciated JJ cord-321150-ev6acl7b 19 10 statistical statistical JJ cord-321150-ev6acl7b 19 11 issues issue NNS cord-321150-ev6acl7b 19 12 arise arise VBP cord-321150-ev6acl7b 19 13 through through IN cord-321150-ev6acl7b 19 14 the the DT cord-321150-ev6acl7b 19 15 extremely extremely RB cord-321150-ev6acl7b 19 16 large large JJ cord-321150-ev6acl7b 19 17 number number NN cord-321150-ev6acl7b 19 18 of of IN cord-321150-ev6acl7b 19 19 compared compare VBN cord-321150-ev6acl7b 19 20 nucleotide nucleotide JJ cord-321150-ev6acl7b 19 21 sequence sequence NN cord-321150-ev6acl7b 19 22 patterns pattern NNS cord-321150-ev6acl7b 19 23 . . . cord-321150-ev6acl7b 20 1 With with IN cord-321150-ev6acl7b 20 2 this this DT cord-321150-ev6acl7b 20 3 many many JJ cord-321150-ev6acl7b 20 4 comparisons comparison NNS cord-321150-ev6acl7b 20 5 being be VBG cord-321150-ev6acl7b 20 6 performed perform VBN cord-321150-ev6acl7b 20 7 , , , cord-321150-ev6acl7b 20 8 truly truly RB cord-321150-ev6acl7b 20 9 nonrecombinant nonrecombinant NN cord-321150-ev6acl7b 20 10 sequences sequence NNS cord-321150-ev6acl7b 20 11 can can MD cord-321150-ev6acl7b 20 12 exhibit exhibit VB cord-321150-ev6acl7b 20 13 nucleotide nucleotide JJ cord-321150-ev6acl7b 20 14 patterns pattern NNS cord-321150-ev6acl7b 20 15 that that WDT cord-321150-ev6acl7b 20 16 appear appear VBP cord-321150-ev6acl7b 20 17 recombinant recombinant JJ cord-321150-ev6acl7b 20 18 by by IN cord-321150-ev6acl7b 20 19 chance chance NN cord-321150-ev6acl7b 20 20 . . . cord-321150-ev6acl7b 21 1 For for IN cord-321150-ev6acl7b 21 2 this this DT cord-321150-ev6acl7b 21 3 reason reason NN cord-321150-ev6acl7b 21 4 , , , cord-321150-ev6acl7b 21 5 statistical statistical JJ cord-321150-ev6acl7b 21 6 corrections correction NNS cord-321150-ev6acl7b 21 7 for for IN cord-321150-ev6acl7b 21 8 multiple multiple JJ cord-321150-ev6acl7b 21 9 comparisons comparison NNS cord-321150-ev6acl7b 21 10 are be VBP cord-321150-ev6acl7b 21 11 essential essential JJ cord-321150-ev6acl7b 21 12 to to TO cord-321150-ev6acl7b 21 13 guard guard VB cord-321150-ev6acl7b 21 14 against against IN cord-321150-ev6acl7b 21 15 calling call VBG cord-321150-ev6acl7b 21 16 spurious spurious JJ cord-321150-ev6acl7b 21 17 recombinants recombinant NNS cord-321150-ev6acl7b 21 18 . . . cord-321150-ev6acl7b 22 1 In in IN cord-321150-ev6acl7b 22 2 an an DT cord-321150-ev6acl7b 22 3 algorithm algorithm NN cord-321150-ev6acl7b 22 4 called call VBN cord-321150-ev6acl7b 22 5 3SEQ 3SEQ NNP cord-321150-ev6acl7b 22 6 , , , cord-321150-ev6acl7b 22 7 Boni Boni NNP cord-321150-ev6acl7b 22 8 et et FW cord-321150-ev6acl7b 22 9 al al NNP cord-321150-ev6acl7b 22 10 . . . cord-321150-ev6acl7b 23 1 ( ( -LRB- cord-321150-ev6acl7b 23 2 2007 2007 CD cord-321150-ev6acl7b 23 3 ) ) -RRB- cord-321150-ev6acl7b 23 4 presented present VBD cord-321150-ev6acl7b 23 5 an an DT cord-321150-ev6acl7b 23 6 exact exact JJ cord-321150-ev6acl7b 23 7 mosaicism mosaicism NN cord-321150-ev6acl7b 23 8 statistic statistic NN cord-321150-ev6acl7b 23 9 for for IN cord-321150-ev6acl7b 23 10 calling call VBG cord-321150-ev6acl7b 23 11 recombinants recombinant NNS cord-321150-ev6acl7b 23 12 . . . cord-321150-ev6acl7b 24 1 Critically critically RB cord-321150-ev6acl7b 24 2 , , , cord-321150-ev6acl7b 24 3 the the DT cord-321150-ev6acl7b 24 4 exactness exactness NN cord-321150-ev6acl7b 24 5 of of IN cord-321150-ev6acl7b 24 6 the the DT cord-321150-ev6acl7b 24 7 computation computation NN cord-321150-ev6acl7b 24 8 ( ( -LRB- cord-321150-ev6acl7b 24 9 e.g. e.g. RB cord-321150-ev6acl7b 24 10 , , , cord-321150-ev6acl7b 24 11 calculating calculate VBG cord-321150-ev6acl7b 24 12 P p NN cord-321150-ev6acl7b 24 13 values value NNS cord-321150-ev6acl7b 24 14 to to IN cord-321150-ev6acl7b 24 15 a a DT cord-321150-ev6acl7b 24 16 precision precision NN cord-321150-ev6acl7b 24 17 of of IN cord-321150-ev6acl7b 24 18 10 10 CD cord-321150-ev6acl7b 24 19 À20 À20 NNP cord-321150-ev6acl7b 24 20 or or CC cord-321150-ev6acl7b 24 21 10 10 CD cord-321150-ev6acl7b 24 22 À30 À30 NNP cord-321150-ev6acl7b 24 23 ) ) -RRB- cord-321150-ev6acl7b 24 24 allows allow VBZ cord-321150-ev6acl7b 24 25 these these DT cord-321150-ev6acl7b 24 26 mosaic mosaic JJ cord-321150-ev6acl7b 24 27 signals signal NNS cord-321150-ev6acl7b 24 28 to to TO cord-321150-ev6acl7b 24 29 remain remain VB cord-321150-ev6acl7b 24 30 statistically statistically RB cord-321150-ev6acl7b 24 31 significant significant JJ cord-321150-ev6acl7b 24 32 , , , cord-321150-ev6acl7b 24 33 even even RB cord-321150-ev6acl7b 24 34 when when WRB cord-321150-ev6acl7b 24 35 billions billion NNS cord-321150-ev6acl7b 24 36 of of IN cord-321150-ev6acl7b 24 37 comparisons comparison NNS cord-321150-ev6acl7b 24 38 are be VBP cord-321150-ev6acl7b 24 39 being be VBG cord-321150-ev6acl7b 24 40 performed perform VBN cord-321150-ev6acl7b 24 41 and and CC cord-321150-ev6acl7b 24 42 adjusted adjust VBN cord-321150-ev6acl7b 24 43 for for IN cord-321150-ev6acl7b 24 44 multiple multiple JJ cord-321150-ev6acl7b 24 45 comparison comparison NN cord-321150-ev6acl7b 24 46 . . . cord-321150-ev6acl7b 25 1 This this DT cord-321150-ev6acl7b 25 2 means mean VBZ cord-321150-ev6acl7b 25 3 that that IN cord-321150-ev6acl7b 25 4 the the DT cord-321150-ev6acl7b 25 5 exact exact JJ cord-321150-ev6acl7b 25 6 mosaicism mosaicism NN cord-321150-ev6acl7b 25 7 statistic statistic NN cord-321150-ev6acl7b 25 8 implemented implement VBN cord-321150-ev6acl7b 25 9 in in IN cord-321150-ev6acl7b 25 10 the the DT cord-321150-ev6acl7b 25 11 3SEQ 3seq CD cord-321150-ev6acl7b 25 12 software software NN cord-321150-ev6acl7b 25 13 maintains maintain VBZ cord-321150-ev6acl7b 25 14 good good JJ cord-321150-ev6acl7b 25 15 power power NN cord-321150-ev6acl7b 25 16 properties property NNS cord-321150-ev6acl7b 25 17 even even RB cord-321150-ev6acl7b 25 18 on on IN cord-321150-ev6acl7b 25 19 large large JJ cord-321150-ev6acl7b 25 20 data data NN cord-321150-ev6acl7b 25 21 sets set NNS cord-321150-ev6acl7b 25 22 when when WRB cord-321150-ev6acl7b 25 23 statistical statistical JJ cord-321150-ev6acl7b 25 24 correction correction NN cord-321150-ev6acl7b 25 25 factors factor NNS cord-321150-ev6acl7b 25 26 for for IN cord-321150-ev6acl7b 25 27 multiple multiple JJ cord-321150-ev6acl7b 25 28 comparisons comparison NNS cord-321150-ev6acl7b 25 29 are be VBP cord-321150-ev6acl7b 25 30 on on IN cord-321150-ev6acl7b 25 31 the the DT cord-321150-ev6acl7b 25 32 order order NN cord-321150-ev6acl7b 25 33 of of IN cord-321150-ev6acl7b 25 34 10 10 CD cord-321150-ev6acl7b 25 35 10 10 CD cord-321150-ev6acl7b 25 36 or or CC cord-321150-ev6acl7b 25 37 more more JJR cord-321150-ev6acl7b 25 38 . . . cord-321150-ev6acl7b 26 1 Recombination recombination NN cord-321150-ev6acl7b 26 2 detection detection NN cord-321150-ev6acl7b 26 3 methods method NNS cord-321150-ev6acl7b 26 4 that that WDT cord-321150-ev6acl7b 26 5 detect detect VBP cord-321150-ev6acl7b 26 6 mosaic mosaic JJ cord-321150-ev6acl7b 26 7 signals signal NNS cord-321150-ev6acl7b 26 8 always always RB cord-321150-ev6acl7b 26 9 take take VBP cord-321150-ev6acl7b 26 10 a a DT cord-321150-ev6acl7b 26 11 triplet triplet NN cord-321150-ev6acl7b 26 12 approach approach NN cord-321150-ev6acl7b 26 13 or or CC cord-321150-ev6acl7b 26 14 a a DT cord-321150-ev6acl7b 26 15 quartet quartet NN cord-321150-ev6acl7b 26 16 approach approach NN cord-321150-ev6acl7b 26 17 , , , cord-321150-ev6acl7b 26 18 positing posit VBG cord-321150-ev6acl7b 26 19 one one CD cord-321150-ev6acl7b 26 20 sequence sequence NN cord-321150-ev6acl7b 26 21 as as IN cord-321150-ev6acl7b 26 22 the the DT cord-321150-ev6acl7b 26 23 candidate candidate NN cord-321150-ev6acl7b 26 24 recombinant recombinant JJ cord-321150-ev6acl7b 26 25 , , , cord-321150-ev6acl7b 26 26 two two CD cord-321150-ev6acl7b 26 27 sequences sequence NNS cord-321150-ev6acl7b 26 28 as as IN cord-321150-ev6acl7b 26 29 the the DT cord-321150-ev6acl7b 26 30 parents parent NNS cord-321150-ev6acl7b 26 31 , , , cord-321150-ev6acl7b 26 32 and and CC cord-321150-ev6acl7b 26 33 possibly possibly RB cord-321150-ev6acl7b 26 34 a a DT cord-321150-ev6acl7b 26 35 fourth fourth JJ cord-321150-ev6acl7b 26 36 sequence sequence NN cord-321150-ev6acl7b 26 37 as as IN cord-321150-ev6acl7b 26 38 an an DT cord-321150-ev6acl7b 26 39 outgroup outgroup NN cord-321150-ev6acl7b 26 40 . . . cord-321150-ev6acl7b 27 1 With with IN cord-321150-ev6acl7b 27 2 the the DT cord-321150-ev6acl7b 27 3 parental parental JJ cord-321150-ev6acl7b 27 4 sequences sequence NNS cord-321150-ev6acl7b 27 5 labeled label VBD cord-321150-ev6acl7b 27 6 P P NNP cord-321150-ev6acl7b 27 7 and and CC cord-321150-ev6acl7b 27 8 Q Q NNP cord-321150-ev6acl7b 27 9 and and CC cord-321150-ev6acl7b 27 10 the the DT cord-321150-ev6acl7b 27 11 candidate candidate NN cord-321150-ev6acl7b 27 12 recombinant recombinant NN cord-321150-ev6acl7b 27 13 labeled label VBN cord-321150-ev6acl7b 27 14 C C NNP cord-321150-ev6acl7b 27 15 , , , cord-321150-ev6acl7b 27 16 these these DT cord-321150-ev6acl7b 27 17 methods method NNS cord-321150-ev6acl7b 27 18 normally normally RB cord-321150-ev6acl7b 27 19 use use VBP cord-321150-ev6acl7b 27 20 " " `` cord-321150-ev6acl7b 27 21 recombination recombination NN cord-321150-ev6acl7b 27 22 informative informative JJ cord-321150-ev6acl7b 27 23 " " '' cord-321150-ev6acl7b 27 24 sites site NNS cord-321150-ev6acl7b 27 25 , , , cord-321150-ev6acl7b 27 26 or or CC cord-321150-ev6acl7b 27 27 simply simply RB cord-321150-ev6acl7b 27 28 informative informative JJ cord-321150-ev6acl7b 27 29 sites site NNS cord-321150-ev6acl7b 27 30 , , , cord-321150-ev6acl7b 27 31 to to TO cord-321150-ev6acl7b 27 32 determine determine VB cord-321150-ev6acl7b 27 33 if if IN cord-321150-ev6acl7b 27 34 C C NNP cord-321150-ev6acl7b 27 35 is be VBZ cord-321150-ev6acl7b 27 36 a a DT cord-321150-ev6acl7b 27 37 mosaic mosaic NN cord-321150-ev6acl7b 27 38 of of IN cord-321150-ev6acl7b 27 39 P p NN cord-321150-ev6acl7b 27 40 and and CC cord-321150-ev6acl7b 27 41 Q. Q. NNP cord-321150-ev6acl7b 28 1 In in IN cord-321150-ev6acl7b 28 2 3SEQ 3seq CD cord-321150-ev6acl7b 28 3 , , , cord-321150-ev6acl7b 28 4 nucleotide nucleotide JJ cord-321150-ev6acl7b 28 5 positions position NNS cord-321150-ev6acl7b 28 6 on on IN cord-321150-ev6acl7b 28 7 C C NNP cord-321150-ev6acl7b 28 8 are be VBP cord-321150-ev6acl7b 28 9 labeled label VBN cord-321150-ev6acl7b 28 10 informative informative JJ cord-321150-ev6acl7b 28 11 if if IN cord-321150-ev6acl7b 28 12 the the DT cord-321150-ev6acl7b 28 13 nucleotide nucleotide NN cord-321150-ev6acl7b 28 14 in in IN cord-321150-ev6acl7b 28 15 C C NNP cord-321150-ev6acl7b 28 16 is be VBZ cord-321150-ev6acl7b 28 17 identical identical JJ cord-321150-ev6acl7b 28 18 to to IN cord-321150-ev6acl7b 28 19 one one CD cord-321150-ev6acl7b 28 20 parental parental JJ cord-321150-ev6acl7b 28 21 sequence sequence NN cord-321150-ev6acl7b 28 22 but but CC cord-321150-ev6acl7b 28 23 different different JJ cord-321150-ev6acl7b 28 24 from from IN cord-321150-ev6acl7b 28 25 the the DT cord-321150-ev6acl7b 28 26 other other JJ cord-321150-ev6acl7b 28 27 . . . cord-321150-ev6acl7b 29 1 If if IN cord-321150-ev6acl7b 29 2 the the DT cord-321150-ev6acl7b 29 3 sequence sequence NN cord-321150-ev6acl7b 29 4 of of IN cord-321150-ev6acl7b 29 5 m m CD cord-321150-ev6acl7b 29 6 informative informative JJ cord-321150-ev6acl7b 29 7 sites site NNS cord-321150-ev6acl7b 29 8 identical identical JJ cord-321150-ev6acl7b 29 9 to to IN cord-321150-ev6acl7b 29 10 P p NN cord-321150-ev6acl7b 29 11 and and CC cord-321150-ev6acl7b 29 12 n n CC cord-321150-ev6acl7b 29 13 informative informative JJ cord-321150-ev6acl7b 29 14 sites site NNS cord-321150-ev6acl7b 29 15 identical identical JJ cord-321150-ev6acl7b 29 16 to to IN cord-321150-ev6acl7b 29 17 Q Q NNP cord-321150-ev6acl7b 29 18 appears appear VBZ cord-321150-ev6acl7b 29 19 nonrandom nonrandom JJ cord-321150-ev6acl7b 29 20 or or CC cord-321150-ev6acl7b 29 21 clustered cluster VBN cord-321150-ev6acl7b 29 22 , , , cord-321150-ev6acl7b 29 23 this this DT cord-321150-ev6acl7b 29 24 is be VBZ cord-321150-ev6acl7b 29 25 an an DT cord-321150-ev6acl7b 29 26 indication indication NN cord-321150-ev6acl7b 29 27 that that IN cord-321150-ev6acl7b 29 28 Letter letter NN cord-321150-ev6acl7b 29 29 ß ß NN cord-321150-ev6acl7b 30 1 The the DT cord-321150-ev6acl7b 30 2 Author Author NNP cord-321150-ev6acl7b 30 3 2017 2017 CD cord-321150-ev6acl7b 30 4 . . . cord-321150-ev6acl7b 31 1 Published publish VBN cord-321150-ev6acl7b 31 2 by by IN cord-321150-ev6acl7b 31 3 Oxford Oxford NNP cord-321150-ev6acl7b 31 4 University University NNP cord-321150-ev6acl7b 31 5 Press Press NNP cord-321150-ev6acl7b 31 6 on on IN cord-321150-ev6acl7b 31 7 behalf behalf NN cord-321150-ev6acl7b 31 8 of of IN cord-321150-ev6acl7b 31 9 the the DT cord-321150-ev6acl7b 31 10 Society Society NNP cord-321150-ev6acl7b 31 11 for for IN cord-321150-ev6acl7b 31 12 Molecular Molecular NNP cord-321150-ev6acl7b 31 13 Biology Biology NNP cord-321150-ev6acl7b 31 14 and and CC cord-321150-ev6acl7b 31 15 Evolution Evolution NNP cord-321150-ev6acl7b 31 16 . . . cord-321150-ev6acl7b 32 1 This this DT cord-321150-ev6acl7b 32 2 is be VBZ cord-321150-ev6acl7b 32 3 an an DT cord-321150-ev6acl7b 32 4 Open Open NNP cord-321150-ev6acl7b 32 5 Access Access NNP cord-321150-ev6acl7b 32 6 article article NN cord-321150-ev6acl7b 32 7 distributed distribute VBN cord-321150-ev6acl7b 32 8 under under IN cord-321150-ev6acl7b 32 9 the the DT cord-321150-ev6acl7b 32 10 terms term NNS cord-321150-ev6acl7b 32 11 of of IN cord-321150-ev6acl7b 32 12 the the DT cord-321150-ev6acl7b 32 13 Creative Creative NNP cord-321150-ev6acl7b 32 14 Commons Commons NNP cord-321150-ev6acl7b 32 15 Attribution Attribution NNP cord-321150-ev6acl7b 32 16 Non Non NNP cord-321150-ev6acl7b 32 17 - - JJ cord-321150-ev6acl7b 32 18 Commercial commercial JJ cord-321150-ev6acl7b 32 19 License license NN cord-321150-ev6acl7b 32 20 ( ( -LRB- cord-321150-ev6acl7b 32 21 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP cord-321150-ev6acl7b 32 22 ) ) -RRB- cord-321150-ev6acl7b 32 23 , , , cord-321150-ev6acl7b 32 24 which which WDT cord-321150-ev6acl7b 32 25 permits permit VBZ cord-321150-ev6acl7b 32 26 non non JJ cord-321150-ev6acl7b 32 27 - - JJ cord-321150-ev6acl7b 32 28 commercial commercial JJ cord-321150-ev6acl7b 32 29 re re NN cord-321150-ev6acl7b 32 30 - - NN cord-321150-ev6acl7b 32 31 use use JJ cord-321150-ev6acl7b 32 32 , , , cord-321150-ev6acl7b 32 33 distribution distribution NN cord-321150-ev6acl7b 32 34 , , , cord-321150-ev6acl7b 32 35 and and CC cord-321150-ev6acl7b 32 36 reproduction reproduction NN cord-321150-ev6acl7b 32 37 in in IN cord-321150-ev6acl7b 32 38 any any DT cord-321150-ev6acl7b 32 39 medium medium NN cord-321150-ev6acl7b 32 40 , , , cord-321150-ev6acl7b 32 41 provided provide VBD cord-321150-ev6acl7b 32 42 the the DT cord-321150-ev6acl7b 32 43 original original JJ cord-321150-ev6acl7b 32 44 work work NN cord-321150-ev6acl7b 32 45 is be VBZ cord-321150-ev6acl7b 32 46 properly properly RB cord-321150-ev6acl7b 32 47 cited cite VBN cord-321150-ev6acl7b 32 48 . . . cord-321150-ev6acl7b 33 1 For for IN cord-321150-ev6acl7b 33 2 commercial commercial JJ cord-321150-ev6acl7b 33 3 re re NN cord-321150-ev6acl7b 33 4 - - NN cord-321150-ev6acl7b 33 5 use use NN cord-321150-ev6acl7b 33 6 , , , cord-321150-ev6acl7b 33 7 please please UH cord-321150-ev6acl7b 33 8 contact contact NN cord-321150-ev6acl7b 33 9 journals.permissions@oup.com journals.permissions@oup.com NNP cord-321150-ev6acl7b 33 10 Open Open NNP cord-321150-ev6acl7b 33 11 Access Access NNP cord-321150-ev6acl7b 33 12 recombination recombination NN cord-321150-ev6acl7b 33 13 may may MD cord-321150-ev6acl7b 33 14 have have VB cord-321150-ev6acl7b 33 15 occurred occur VBN cord-321150-ev6acl7b 33 16 . . . cord-321150-ev6acl7b 34 1 When when WRB cord-321150-ev6acl7b 34 2 read read VBN cord-321150-ev6acl7b 34 3 from from IN cord-321150-ev6acl7b 34 4 left leave VBN cord-321150-ev6acl7b 34 5 to to IN cord-321150-ev6acl7b 34 6 right right RB cord-321150-ev6acl7b 34 7 along along IN cord-321150-ev6acl7b 34 8 the the DT cord-321150-ev6acl7b 34 9 sequence sequence NN cord-321150-ev6acl7b 34 10 , , , cord-321150-ev6acl7b 34 11 the the DT cord-321150-ev6acl7b 34 12 informative informative JJ cord-321150-ev6acl7b 34 13 sites site NNS cord-321150-ev6acl7b 34 14 can can MD cord-321150-ev6acl7b 34 15 be be VB cord-321150-ev6acl7b 34 16 used use VBN cord-321150-ev6acl7b 34 17 to to TO cord-321150-ev6acl7b 34 18 draw draw VB cord-321150-ev6acl7b 34 19 a a DT cord-321150-ev6acl7b 34 20 random random JJ cord-321150-ev6acl7b 34 21 walk walk NN cord-321150-ev6acl7b 34 22 on on IN cord-321150-ev6acl7b 34 23 a a DT cord-321150-ev6acl7b 34 24 set set NN cord-321150-ev6acl7b 34 25 of of IN cord-321150-ev6acl7b 34 26 axes axis NNS cord-321150-ev6acl7b 34 27 with with IN cord-321150-ev6acl7b 34 28 m m NNP cord-321150-ev6acl7b 34 29 up up RB cord-321150-ev6acl7b 34 30 - - HYPH cord-321150-ev6acl7b 34 31 steps step NNS cord-321150-ev6acl7b 34 32 and and CC cord-321150-ev6acl7b 34 33 n n CC cord-321150-ev6acl7b 34 34 down down RB cord-321150-ev6acl7b 34 35 - - HYPH cord-321150-ev6acl7b 34 36 steps step NNS cord-321150-ev6acl7b 34 37 ; ; : cord-321150-ev6acl7b 34 38 this this DT cord-321150-ev6acl7b 34 39 is be VBZ cord-321150-ev6acl7b 34 40 called call VBN cord-321150-ev6acl7b 34 41 a a DT cord-321150-ev6acl7b 34 42 hypergeometric hypergeometric JJ cord-321150-ev6acl7b 34 43 random random JJ cord-321150-ev6acl7b 34 44 walk walk NN cord-321150-ev6acl7b 34 45 ( ( -LRB- cord-321150-ev6acl7b 34 46 HGRW HGRW NNP cord-321150-ev6acl7b 34 47 ) ) -RRB- cord-321150-ev6acl7b 34 48 . . . cord-321150-ev6acl7b 35 1 A a DT cord-321150-ev6acl7b 35 2 strong strong JJ cord-321150-ev6acl7b 35 3 descent descent NN cord-321150-ev6acl7b 35 4 or or CC cord-321150-ev6acl7b 35 5 ascent ascent NN cord-321150-ev6acl7b 35 6 in in IN cord-321150-ev6acl7b 35 7 the the DT cord-321150-ev6acl7b 35 8 middle middle NN cord-321150-ev6acl7b 35 9 of of IN cord-321150-ev6acl7b 35 10 a a DT cord-321150-ev6acl7b 35 11 HGRW HGRW NNP cord-321150-ev6acl7b 35 12 indicates indicate VBZ cord-321150-ev6acl7b 35 13 that that IN cord-321150-ev6acl7b 35 14 one one CD cord-321150-ev6acl7b 35 15 type type NN cord-321150-ev6acl7b 35 16 of of IN cord-321150-ev6acl7b 35 17 informative informative JJ cord-321150-ev6acl7b 35 18 site site NN cord-321150-ev6acl7b 35 19 exhibits exhibit VBZ cord-321150-ev6acl7b 35 20 clustering clustering NN cord-321150-ev6acl7b 35 21 , , , cord-321150-ev6acl7b 35 22 and and CC cord-321150-ev6acl7b 35 23 the the DT cord-321150-ev6acl7b 35 24 properties property NNS cord-321150-ev6acl7b 35 25 of of IN cord-321150-ev6acl7b 35 26 the the DT cord-321150-ev6acl7b 35 27 random random JJ cord-321150-ev6acl7b 35 28 walk walk NN cord-321150-ev6acl7b 35 29 can can MD cord-321150-ev6acl7b 35 30 be be VB cord-321150-ev6acl7b 35 31 used use VBN cord-321150-ev6acl7b 35 32 to to TO cord-321150-ev6acl7b 35 33 compute compute VB cord-321150-ev6acl7b 35 34 exact exact JJ cord-321150-ev6acl7b 35 35 probabilities probability NNS cord-321150-ev6acl7b 35 36 of of IN cord-321150-ev6acl7b 35 37 this this DT cord-321150-ev6acl7b 35 38 occurring occurring NN cord-321150-ev6acl7b 35 39 . . . cord-321150-ev6acl7b 36 1 See see VB cord-321150-ev6acl7b 36 2 figure figure NN cord-321150-ev6acl7b 36 3 1 1 CD cord-321150-ev6acl7b 36 4 for for IN cord-321150-ev6acl7b 36 5 an an DT cord-321150-ev6acl7b 36 6 example example NN cord-321150-ev6acl7b 36 7 . . . cord-321150-ev6acl7b 37 1 In in IN cord-321150-ev6acl7b 37 2 this this DT cord-321150-ev6acl7b 37 3 letter letter NN cord-321150-ev6acl7b 37 4 , , , cord-321150-ev6acl7b 37 5 we -PRON- PRP cord-321150-ev6acl7b 37 6 present present VBP cord-321150-ev6acl7b 37 7 a a DT cord-321150-ev6acl7b 37 8 new new JJ cord-321150-ev6acl7b 37 9 and and CC cord-321150-ev6acl7b 37 10 faster fast JJR cord-321150-ev6acl7b 37 11 method method NN cord-321150-ev6acl7b 37 12 of of IN cord-321150-ev6acl7b 37 13 computing compute VBG cord-321150-ev6acl7b 37 14 these these DT cord-321150-ev6acl7b 37 15 probabilities probability NNS cord-321150-ev6acl7b 37 16 . . . cord-321150-ev6acl7b 38 1 The the DT cord-321150-ev6acl7b 38 2 central central JJ cord-321150-ev6acl7b 38 3 feature feature NN cord-321150-ev6acl7b 38 4 of of IN cord-321150-ev6acl7b 38 5 3SEQ 3SEQ NNP cord-321150-ev6acl7b 38 6 was be VBD cord-321150-ev6acl7b 38 7 a a DT cord-321150-ev6acl7b 38 8 reduction reduction NN cord-321150-ev6acl7b 38 9 of of IN cord-321150-ev6acl7b 38 10 an an DT cord-321150-ev6acl7b 38 11 O(2 O(2 NNP cord-321150-ev6acl7b 38 12 mþn mþn NN cord-321150-ev6acl7b 38 13 ) ) -RRB- cord-321150-ev6acl7b 38 14 space space NN cord-321150-ev6acl7b 38 15 - - HYPH cord-321150-ev6acl7b 38 16 complexity complexity NN cord-321150-ev6acl7b 38 17 problem problem NN cord-321150-ev6acl7b 38 18 into into IN cord-321150-ev6acl7b 38 19 an an DT cord-321150-ev6acl7b 38 20 O(mn o(mn NN cord-321150-ev6acl7b 38 21 3 3 CD cord-321150-ev6acl7b 38 22 ) ) -RRB- cord-321150-ev6acl7b 38 23 problem problem NN cord-321150-ev6acl7b 38 24 , , , cord-321150-ev6acl7b 38 25 for for IN cord-321150-ev6acl7b 38 26 computing compute VBG cord-321150-ev6acl7b 38 27 the the DT cord-321150-ev6acl7b 38 28 probability probability NN cord-321150-ev6acl7b 38 29 x x SYM cord-321150-ev6acl7b 38 30 m m NNP cord-321150-ev6acl7b 38 31 , , , cord-321150-ev6acl7b 38 32 n n NNP cord-321150-ev6acl7b 38 33 , , , cord-321150-ev6acl7b 38 34 k k NNP cord-321150-ev6acl7b 38 35 that that IN cord-321150-ev6acl7b 38 36 a a DT cord-321150-ev6acl7b 38 37 HGRW HGRW NNP cord-321150-ev6acl7b 38 38 with with IN cord-321150-ev6acl7b 38 39 m m NNP cord-321150-ev6acl7b 38 40 up up RB cord-321150-ev6acl7b 38 41 - - HYPH cord-321150-ev6acl7b 38 42 steps step NNS cord-321150-ev6acl7b 38 43 and and CC cord-321150-ev6acl7b 38 44 n n CC cord-321150-ev6acl7b 38 45 down down RB cord-321150-ev6acl7b 38 46 - - HYPH cord-321150-ev6acl7b 38 47 steps step NNS cord-321150-ev6acl7b 38 48 achieves achieve VBZ cord-321150-ev6acl7b 38 49 a a DT cord-321150-ev6acl7b 38 50 maximum maximum JJ cord-321150-ev6acl7b 38 51 descent descent NN cord-321150-ev6acl7b 38 52 of of IN cord-321150-ev6acl7b 38 53 size size NN cord-321150-ev6acl7b 38 54 k k NNP cord-321150-ev6acl7b 38 55 exactly exactly RB cord-321150-ev6acl7b 38 56 . . . cord-321150-ev6acl7b 39 1 The the DT cord-321150-ev6acl7b 39 2 descent descent NN cord-321150-ev6acl7b 39 3 does do VBZ cord-321150-ev6acl7b 39 4 not not RB cord-321150-ev6acl7b 39 5 need need VB cord-321150-ev6acl7b 39 6 to to TO cord-321150-ev6acl7b 39 7 be be VB cord-321150-ev6acl7b 39 8 k k XX cord-321150-ev6acl7b 39 9 consecutive consecutive JJ cord-321150-ev6acl7b 39 10 down down JJ cord-321150-ev6acl7b 39 11 steps step NNS cord-321150-ev6acl7b 39 12 . . . cord-321150-ev6acl7b 40 1 The the DT cord-321150-ev6acl7b 40 2 computations computation NNS cord-321150-ev6acl7b 40 3 were be VBD cord-321150-ev6acl7b 40 4 done do VBN cord-321150-ev6acl7b 40 5 via via IN cord-321150-ev6acl7b 40 6 auxiliary auxiliary JJ cord-321150-ev6acl7b 40 7 variables variable NNS cord-321150-ev6acl7b 41 1 y y NNP cord-321150-ev6acl7b 41 2 m m NNP cord-321150-ev6acl7b 41 3 , , , cord-321150-ev6acl7b 41 4 n n NNP cord-321150-ev6acl7b 41 5 , , , cord-321150-ev6acl7b 41 6 k k NNP cord-321150-ev6acl7b 41 7 , , , cord-321150-ev6acl7b 41 8 j j NNP cord-321150-ev6acl7b 41 9 : : : cord-321150-ev6acl7b 42 1 the the DT cord-321150-ev6acl7b 42 2 probability probability NN cord-321150-ev6acl7b 42 3 that that IN cord-321150-ev6acl7b 42 4 a a DT cord-321150-ev6acl7b 42 5 HGRW HGRW NNP cord-321150-ev6acl7b 42 6 with with IN cord-321150-ev6acl7b 42 7 m m NNP cord-321150-ev6acl7b 42 8 up up RB cord-321150-ev6acl7b 42 9 - - HYPH cord-321150-ev6acl7b 42 10 steps step NNS cord-321150-ev6acl7b 42 11 and and CC cord-321150-ev6acl7b 42 12 n n CC cord-321150-ev6acl7b 42 13 down down RB cord-321150-ev6acl7b 42 14 - - HYPH cord-321150-ev6acl7b 42 15 steps step NNS cord-321150-ev6acl7b 42 16 achieves achieve VBZ cord-321150-ev6acl7b 42 17 a a DT cord-321150-ev6acl7b 42 18 maximum maximum JJ cord-321150-ev6acl7b 42 19 descent descent NN cord-321150-ev6acl7b 42 20 of of IN cord-321150-ev6acl7b 42 21 size size NN cord-321150-ev6acl7b 42 22 k k NNP cord-321150-ev6acl7b 42 23 exactly exactly RB cord-321150-ev6acl7b 42 24 and and CC cord-321150-ev6acl7b 42 25 the the DT cord-321150-ev6acl7b 42 26 minimum minimum JJ cord-321150-ev6acl7b 42 27 value value NN cord-321150-ev6acl7b 42 28 achieved achieve VBN cord-321150-ev6acl7b 42 29 by by IN cord-321150-ev6acl7b 42 30 the the DT cord-321150-ev6acl7b 42 31 random random JJ cord-321150-ev6acl7b 42 32 walk walk NN cord-321150-ev6acl7b 42 33 is be VBZ cord-321150-ev6acl7b 42 34 exactly exactly RB cord-321150-ev6acl7b 42 35 j j NNP cord-321150-ev6acl7b 42 36 units unit NNS cord-321150-ev6acl7b 42 37 below below IN cord-321150-ev6acl7b 42 38 the the DT cord-321150-ev6acl7b 42 39 origin origin NN cord-321150-ev6acl7b 42 40 . . . cord-321150-ev6acl7b 43 1 The the DT cord-321150-ev6acl7b 43 2 y y NN cord-321150-ev6acl7b 43 3 - - HYPH cord-321150-ev6acl7b 43 4 variables variable NNS cord-321150-ev6acl7b 43 5 can can MD cord-321150-ev6acl7b 43 6 be be VB cord-321150-ev6acl7b 43 7 computed compute VBN cord-321150-ev6acl7b 43 8 recursively recursively RB cord-321150-ev6acl7b 43 9 ( ( -LRB- cord-321150-ev6acl7b 43 10 Boni boni FW cord-321150-ev6acl7b 43 11 et et FW cord-321150-ev6acl7b 43 12 al al NNP cord-321150-ev6acl7b 43 13 . . NNP cord-321150-ev6acl7b 43 14 2007 2007 CD cord-321150-ev6acl7b 43 15 ) ) -RRB- cord-321150-ev6acl7b 43 16 by by IN cord-321150-ev6acl7b 43 17 building build VBG cord-321150-ev6acl7b 43 18 a a DT cord-321150-ev6acl7b 43 19 table table NN cord-321150-ev6acl7b 43 20 of of IN cord-321150-ev6acl7b 43 21 size size NN cord-321150-ev6acl7b 43 22 mn mn NNP cord-321150-ev6acl7b 43 23 3 3 CD cord-321150-ev6acl7b 43 24 . . . cord-321150-ev6acl7b 44 1 The the DT cord-321150-ev6acl7b 44 2 x x NNS cord-321150-ev6acl7b 44 3 - - NNS cord-321150-ev6acl7b 44 4 variables variable NNS cord-321150-ev6acl7b 44 5 are be VBP cord-321150-ev6acl7b 44 6 then then RB cord-321150-ev6acl7b 44 7 computed compute VBN cord-321150-ev6acl7b 44 8 as as IN cord-321150-ev6acl7b 44 9 follows follow VBZ cord-321150-ev6acl7b 44 10 : : : cord-321150-ev6acl7b 44 11 By by IN cord-321150-ev6acl7b 44 12 separating separate VBG cord-321150-ev6acl7b 44 13 out out RP cord-321150-ev6acl7b 44 14 the the DT cord-321150-ev6acl7b 44 15 first first JJ cord-321150-ev6acl7b 44 16 and and CC cord-321150-ev6acl7b 44 17 last last JJ cord-321150-ev6acl7b 44 18 term term NN cord-321150-ev6acl7b 44 19 in in IN cord-321150-ev6acl7b 44 20 the the DT cord-321150-ev6acl7b 44 21 sum sum NN cord-321150-ev6acl7b 44 22 above above RB cord-321150-ev6acl7b 44 23 , , , cord-321150-ev6acl7b 44 24 and and CC cord-321150-ev6acl7b 44 25 using use VBG cord-321150-ev6acl7b 44 26 the the DT cord-321150-ev6acl7b 44 27 y y NNP cord-321150-ev6acl7b 44 28 - - HYPH cord-321150-ev6acl7b 44 29 variable variable JJ cord-321150-ev6acl7b 44 30 recursions recursion NNS cord-321150-ev6acl7b 44 31 , , , cord-321150-ev6acl7b 44 32 a a DT cord-321150-ev6acl7b 44 33 nearly nearly RB cord-321150-ev6acl7b 44 34 direct direct JJ cord-321150-ev6acl7b 44 35 recursion recursion NN cord-321150-ev6acl7b 44 36 can can MD cord-321150-ev6acl7b 44 37 be be VB cord-321150-ev6acl7b 44 38 written write VBN cord-321150-ev6acl7b 44 39 for for IN cord-321150-ev6acl7b 44 40 the the DT cord-321150-ev6acl7b 44 41 x x NNS cord-321150-ev6acl7b 44 42 - - NNS cord-321150-ev6acl7b 44 43 variables variable NNS cord-321150-ev6acl7b 44 44 : : : cord-321150-ev6acl7b 45 1 The the DT cord-321150-ev6acl7b 45 2 P p NN cord-321150-ev6acl7b 45 3 value value NN cord-321150-ev6acl7b 45 4 for for IN cord-321150-ev6acl7b 45 5 observing observe VBG cord-321150-ev6acl7b 45 6 a a DT cord-321150-ev6acl7b 45 7 maximum maximum JJ cord-321150-ev6acl7b 45 8 descent descent NN cord-321150-ev6acl7b 45 9 of of IN cord-321150-ev6acl7b 45 10 size size NN cord-321150-ev6acl7b 45 11 at at IN cord-321150-ev6acl7b 45 12 least least JJS cord-321150-ev6acl7b 45 13 k k NNP cord-321150-ev6acl7b 45 14 is be VBZ cord-321150-ev6acl7b 45 15 defined define VBN cord-321150-ev6acl7b 45 16 by by IN cord-321150-ev6acl7b 45 17 and and CC cord-321150-ev6acl7b 45 18 recursions recursion NNS cord-321150-ev6acl7b 45 19 for for IN cord-321150-ev6acl7b 45 20 the the DT cord-321150-ev6acl7b 45 21 p p NN cord-321150-ev6acl7b 45 22 - - HYPH cord-321150-ev6acl7b 45 23 variables variable NNS cord-321150-ev6acl7b 45 24 reduce reduce VBP cord-321150-ev6acl7b 45 25 to to IN cord-321150-ev6acl7b 45 26 : : : cord-321150-ev6acl7b 45 27 The the DT cord-321150-ev6acl7b 45 28 y y NN cord-321150-ev6acl7b 45 29 - - HYPH cord-321150-ev6acl7b 45 30 variables variable NNS cord-321150-ev6acl7b 45 31 in in IN cord-321150-ev6acl7b 45 32 equation equation NN cord-321150-ev6acl7b 45 33 ( ( -LRB- cord-321150-ev6acl7b 45 34 2 2 CD cord-321150-ev6acl7b 45 35 ) ) -RRB- cord-321150-ev6acl7b 45 36 above- above- NN cord-321150-ev6acl7b 46 1 since since IN cord-321150-ev6acl7b 46 2 the the DT cord-321150-ev6acl7b 46 3 last last JJ cord-321150-ev6acl7b 46 4 two two CD cord-321150-ev6acl7b 46 5 indices index NNS cord-321150-ev6acl7b 46 6 are be VBP cord-321150-ev6acl7b 46 7 equal equal JJ cord-321150-ev6acl7b 46 8 - - : cord-321150-ev6acl7b 46 9 can can MD cord-321150-ev6acl7b 46 10 be be VB cord-321150-ev6acl7b 46 11 computed compute VBN cord-321150-ev6acl7b 46 12 recursively recursively RB cord-321150-ev6acl7b 46 13 by by IN cord-321150-ev6acl7b 46 14 building build VBG cord-321150-ev6acl7b 46 15 one one CD cord-321150-ev6acl7b 46 16 table table NN cord-321150-ev6acl7b 46 17 of of IN cord-321150-ev6acl7b 46 18 size size NN cord-321150-ev6acl7b 46 19 mn mn NNP cord-321150-ev6acl7b 46 20 2 2 CD cord-321150-ev6acl7b 46 21 . . . cord-321150-ev6acl7b 47 1 The the DT cord-321150-ev6acl7b 47 2 p p NN cord-321150-ev6acl7b 47 3 - - HYPH cord-321150-ev6acl7b 47 4 variables variable NNS cord-321150-ev6acl7b 47 5 can can MD cord-321150-ev6acl7b 47 6 be be VB cord-321150-ev6acl7b 47 7 recursively recursively RB cord-321150-ev6acl7b 47 8 computed compute VBN cord-321150-ev6acl7b 47 9 by by IN cord-321150-ev6acl7b 47 10 building build VBG cord-321150-ev6acl7b 47 11 a a DT cord-321150-ev6acl7b 47 12 second second JJ cord-321150-ev6acl7b 47 13 table table NN cord-321150-ev6acl7b 47 14 of of IN cord-321150-ev6acl7b 47 15 size size NN cord-321150-ev6acl7b 47 16 mn mn NNP cord-321150-ev6acl7b 47 17 2 2 CD cord-321150-ev6acl7b 47 18 . . . cord-321150-ev6acl7b 48 1 This this DT cord-321150-ev6acl7b 48 2 means mean VBZ cord-321150-ev6acl7b 48 3 that that IN cord-321150-ev6acl7b 48 4 the the DT cord-321150-ev6acl7b 48 5 entire entire JJ cord-321150-ev6acl7b 48 6 computational computational JJ cord-321150-ev6acl7b 48 7 procedure procedure NN cord-321150-ev6acl7b 48 8 of of IN cord-321150-ev6acl7b 48 9 P p NN cord-321150-ev6acl7b 48 10 values value NNS cord-321150-ev6acl7b 48 11 can can MD cord-321150-ev6acl7b 48 12 be be VB cord-321150-ev6acl7b 48 13 done do VBN cord-321150-ev6acl7b 48 14 with with IN cord-321150-ev6acl7b 48 15 space space NN cord-321150-ev6acl7b 48 16 complexity complexity NN cord-321150-ev6acl7b 49 1 O(mn o(mn NN cord-321150-ev6acl7b 49 2 2 2 CD cord-321150-ev6acl7b 49 3 ) ) -RRB- cord-321150-ev6acl7b 50 1 instead instead RB cord-321150-ev6acl7b 50 2 of of IN cord-321150-ev6acl7b 50 3 the the DT cord-321150-ev6acl7b 50 4 original original JJ cord-321150-ev6acl7b 50 5 O(mn o(mn NN cord-321150-ev6acl7b 50 6 3 3 CD cord-321150-ev6acl7b 50 7 ) ) -RRB- cord-321150-ev6acl7b 50 8 presented present VBN cord-321150-ev6acl7b 50 9 in in IN cord-321150-ev6acl7b 50 10 Boni Boni NNP cord-321150-ev6acl7b 50 11 et et FW cord-321150-ev6acl7b 50 12 al al NNP cord-321150-ev6acl7b 50 13 . . . cord-321150-ev6acl7b 51 1 ( ( -LRB- cord-321150-ev6acl7b 51 2 2007 2007 CD cord-321150-ev6acl7b 51 3 ) ) -RRB- cord-321150-ev6acl7b 51 4 . . . cord-321150-ev6acl7b 52 1 All all DT cord-321150-ev6acl7b 52 2 computations computation NNS cord-321150-ev6acl7b 52 3 were be VBD cord-321150-ev6acl7b 52 4 verified verify VBN cord-321150-ev6acl7b 52 5 against against IN cord-321150-ev6acl7b 52 6 the the DT cord-321150-ev6acl7b 52 7 original original JJ cord-321150-ev6acl7b 52 8 approach approach NN cord-321150-ev6acl7b 52 9 . . . cord-321150-ev6acl7b 53 1 This this DT cord-321150-ev6acl7b 53 2 new new JJ cord-321150-ev6acl7b 53 3 approach approach NN cord-321150-ev6acl7b 53 4 allows allow VBZ cord-321150-ev6acl7b 53 5 larger large JJR cord-321150-ev6acl7b 53 6 probability probability NN cord-321150-ev6acl7b 53 7 tables table NNS cord-321150-ev6acl7b 53 8 to to TO cord-321150-ev6acl7b 53 9 be be VB cord-321150-ev6acl7b 53 10 built build VBN cord-321150-ev6acl7b 53 11 more more RBR cord-321150-ev6acl7b 53 12 quickly quickly RB cord-321150-ev6acl7b 53 13 . . . cord-321150-ev6acl7b 54 1 Using use VBG cord-321150-ev6acl7b 54 2 the the DT cord-321150-ev6acl7b 54 3 2007 2007 CD cord-321150-ev6acl7b 54 4 recursions recursion NNS cord-321150-ev6acl7b 54 5 , , , cord-321150-ev6acl7b 54 6 a a DT cord-321150-ev6acl7b 54 7 table table NN cord-321150-ev6acl7b 54 8 of of IN cord-321150-ev6acl7b 54 9 size size NN cord-321150-ev6acl7b 54 10 700 700 CD cord-321150-ev6acl7b 54 11 Â â NN cord-321150-ev6acl7b 54 12 700 700 CD cord-321150-ev6acl7b 54 13 Â â NN cord-321150-ev6acl7b 54 14 700 700 CD cord-321150-ev6acl7b 54 15 was be VBD cord-321150-ev6acl7b 54 16 built build VBN cord-321150-ev6acl7b 54 17 in in IN cord-321150-ev6acl7b 54 18 9 9 CD cord-321150-ev6acl7b 54 19 h h NN cord-321150-ev6acl7b 54 20 and and CC cord-321150-ev6acl7b 54 21 used use VBD cord-321150-ev6acl7b 54 22 5.1-GB 5.1-gb CD cord-321150-ev6acl7b 54 23 RAM RAM NNP cord-321150-ev6acl7b 54 24 ( ( -LRB- cord-321150-ev6acl7b 54 25 2.6 2.6 CD cord-321150-ev6acl7b 54 26 GHz GHz NNS cord-321150-ev6acl7b 54 27 processor processor NN cord-321150-ev6acl7b 54 28 ; ; : cord-321150-ev6acl7b 54 29 16-GB 16-gb CD cord-321150-ev6acl7b 54 30 RAM ram NN cord-321150-ev6acl7b 54 31 ) ) -RRB- cord-321150-ev6acl7b 54 32 . . . cord-321150-ev6acl7b 55 1 Using use VBG cord-321150-ev6acl7b 55 2 the the DT cord-321150-ev6acl7b 55 3 recursions recursion NNS cord-321150-ev6acl7b 55 4 above above RB cord-321150-ev6acl7b 55 5 , , , cord-321150-ev6acl7b 55 6 a a DT cord-321150-ev6acl7b 55 7 table table NN cord-321150-ev6acl7b 55 8 of of IN cord-321150-ev6acl7b 55 9 1,600 1,600 CD cord-321150-ev6acl7b 55 10 Â â CD cord-321150-ev6acl7b 55 11 1,600 1,600 CD cord-321150-ev6acl7b 55 12 Â â NN cord-321150-ev6acl7b 55 13 1,600 1,600 CD cord-321150-ev6acl7b 55 14 was be VBD cord-321150-ev6acl7b 55 15 built build VBN cord-321150-ev6acl7b 55 16 in in IN cord-321150-ev6acl7b 55 17 1 1 CD cord-321150-ev6acl7b 55 18 h h NN cord-321150-ev6acl7b 55 19 and and CC cord-321150-ev6acl7b 55 20 42 42 CD cord-321150-ev6acl7b 55 21 min min NNS cord-321150-ev6acl7b 55 22 in in IN cord-321150-ev6acl7b 55 23 a a DT cord-321150-ev6acl7b 55 24 10.4-GB 10.4-gb CD cord-321150-ev6acl7b 55 25 memory memory NN cord-321150-ev6acl7b 55 26 footprint footprint NN cord-321150-ev6acl7b 55 27 . . . cord-321150-ev6acl7b 56 1 Two two CD cord-321150-ev6acl7b 56 2 other other JJ cord-321150-ev6acl7b 56 3 noteworthy noteworthy JJ cord-321150-ev6acl7b 56 4 improvements improvement NNS cord-321150-ev6acl7b 56 5 were be VBD cord-321150-ev6acl7b 56 6 made make VBN cord-321150-ev6acl7b 56 7 to to IN cord-321150-ev6acl7b 56 8 the the DT cord-321150-ev6acl7b 56 9 algorithm algorithm NN cord-321150-ev6acl7b 56 10 : : : cord-321150-ev6acl7b 56 11 1 1 LS cord-321150-ev6acl7b 56 12 ) ) -RRB- cord-321150-ev6acl7b 56 13 faster fast JJR cord-321150-ev6acl7b 56 14 breakpoint breakpoint NN cord-321150-ev6acl7b 56 15 calculations calculation NNS cord-321150-ev6acl7b 56 16 by by IN cord-321150-ev6acl7b 56 17 using use VBG cord-321150-ev6acl7b 56 18 polymorphic polymorphic JJ cord-321150-ev6acl7b 56 19 sites site NNS cord-321150-ev6acl7b 56 20 only only RB cord-321150-ev6acl7b 56 21 in in IN cord-321150-ev6acl7b 56 22 Relationship relationship NN cord-321150-ev6acl7b 56 23 between between IN cord-321150-ev6acl7b 56 24 ordering ordering NN cord-321150-ev6acl7b 56 25 of of IN cord-321150-ev6acl7b 56 26 informative informative JJ cord-321150-ev6acl7b 56 27 sites site NNS cord-321150-ev6acl7b 56 28 along along IN cord-321150-ev6acl7b 56 29 a a DT cord-321150-ev6acl7b 56 30 genome genome NN cord-321150-ev6acl7b 56 31 and and CC cord-321150-ev6acl7b 56 32 a a DT cord-321150-ev6acl7b 56 33 hypergeometric hypergeometric JJ cord-321150-ev6acl7b 56 34 random random JJ cord-321150-ev6acl7b 56 35 walk walk NN cord-321150-ev6acl7b 56 36 . . . cord-321150-ev6acl7b 57 1 Below below IN cord-321150-ev6acl7b 57 2 each each DT cord-321150-ev6acl7b 57 3 set set NN cord-321150-ev6acl7b 57 4 of of IN cord-321150-ev6acl7b 57 5 axes axis NNS cord-321150-ev6acl7b 57 6 , , , cord-321150-ev6acl7b 57 7 the the DT cord-321150-ev6acl7b 57 8 30 30 CD cord-321150-ev6acl7b 57 9 red red JJ cord-321150-ev6acl7b 57 10 bars bar NNS cord-321150-ev6acl7b 57 11 and and CC cord-321150-ev6acl7b 57 12 30 30 CD cord-321150-ev6acl7b 57 13 blue blue JJ cord-321150-ev6acl7b 57 14 bars bar NNS cord-321150-ev6acl7b 57 15 show show VBP cord-321150-ev6acl7b 57 16 positions position NNS cord-321150-ev6acl7b 57 17 on on IN cord-321150-ev6acl7b 57 18 a a DT cord-321150-ev6acl7b 57 19 genome genome NN cord-321150-ev6acl7b 57 20 ( ( -LRB- cord-321150-ev6acl7b 57 21 informative informative JJ cord-321150-ev6acl7b 57 22 sites site NNS cord-321150-ev6acl7b 57 23 ) ) -RRB- cord-321150-ev6acl7b 57 24 where where WRB cord-321150-ev6acl7b 57 25 a a DT cord-321150-ev6acl7b 57 26 putative putative JJ cord-321150-ev6acl7b 57 27 recombinant recombinant JJ cord-321150-ev6acl7b 57 28 sequence sequence NN cord-321150-ev6acl7b 57 29 is be VBZ cord-321150-ev6acl7b 57 30 identical identical JJ cord-321150-ev6acl7b 57 31 to to IN cord-321150-ev6acl7b 57 32 parent parent NN cord-321150-ev6acl7b 57 33 P p NN cord-321150-ev6acl7b 57 34 but but CC cord-321150-ev6acl7b 57 35 different different JJ cord-321150-ev6acl7b 57 36 from from IN cord-321150-ev6acl7b 57 37 parent parent NN cord-321150-ev6acl7b 57 38 Q Q NNP cord-321150-ev6acl7b 57 39 ( ( -LRB- cord-321150-ev6acl7b 57 40 blue blue JJ cord-321150-ev6acl7b 57 41 bars bar NNS cord-321150-ev6acl7b 57 42 ) ) -RRB- cord-321150-ev6acl7b 57 43 , , , cord-321150-ev6acl7b 57 44 or or CC cord-321150-ev6acl7b 57 45 identical identical JJ cord-321150-ev6acl7b 57 46 to to IN cord-321150-ev6acl7b 57 47 parent parent NN cord-321150-ev6acl7b 57 48 Q q NN cord-321150-ev6acl7b 57 49 but but CC cord-321150-ev6acl7b 57 50 different different JJ cord-321150-ev6acl7b 57 51 from from IN cord-321150-ev6acl7b 57 52 parent parent NN cord-321150-ev6acl7b 57 53 P p NN cord-321150-ev6acl7b 57 54 ( ( -LRB- cord-321150-ev6acl7b 57 55 red red JJ cord-321150-ev6acl7b 57 56 bars bar NNS cord-321150-ev6acl7b 57 57 ) ) -RRB- cord-321150-ev6acl7b 57 58 . . . cord-321150-ev6acl7b 58 1 Each each DT cord-321150-ev6acl7b 58 2 blue blue JJ cord-321150-ev6acl7b 58 3 site site NN cord-321150-ev6acl7b 58 4 can can MD cord-321150-ev6acl7b 58 5 be be VB cord-321150-ev6acl7b 58 6 mapped map VBN cord-321150-ev6acl7b 58 7 to to IN cord-321150-ev6acl7b 58 8 an an DT cord-321150-ev6acl7b 58 9 up up JJ cord-321150-ev6acl7b 58 10 - - HYPH cord-321150-ev6acl7b 58 11 step step NN cord-321150-ev6acl7b 58 12 in in IN cord-321150-ev6acl7b 58 13 a a DT cord-321150-ev6acl7b 58 14 random random JJ cord-321150-ev6acl7b 58 15 walk walk NN cord-321150-ev6acl7b 58 16 and and CC cord-321150-ev6acl7b 58 17 each each DT cord-321150-ev6acl7b 58 18 red red JJ cord-321150-ev6acl7b 58 19 site site NN cord-321150-ev6acl7b 58 20 can can MD cord-321150-ev6acl7b 58 21 be be VB cord-321150-ev6acl7b 58 22 mapped map VBN cord-321150-ev6acl7b 58 23 to to IN cord-321150-ev6acl7b 58 24 a a DT cord-321150-ev6acl7b 58 25 down down JJ cord-321150-ev6acl7b 58 26 - - HYPH cord-321150-ev6acl7b 58 27 step step NN cord-321150-ev6acl7b 58 28 in in IN cord-321150-ev6acl7b 58 29 a a DT cord-321150-ev6acl7b 58 30 random random JJ cord-321150-ev6acl7b 58 31 walk walk NN cord-321150-ev6acl7b 58 32 , , , cord-321150-ev6acl7b 58 33 and and CC cord-321150-ev6acl7b 58 34 there there EX cord-321150-ev6acl7b 58 35 is be VBZ cord-321150-ev6acl7b 58 36 a a DT cord-321150-ev6acl7b 58 37 one one CD cord-321150-ev6acl7b 58 38 - - HYPH cord-321150-ev6acl7b 58 39 to to IN cord-321150-ev6acl7b 58 40 - - HYPH cord-321150-ev6acl7b 58 41 one one CD cord-321150-ev6acl7b 58 42 correspondence correspondence NN cord-321150-ev6acl7b 58 43 between between IN cord-321150-ev6acl7b 58 44 the the DT cord-321150-ev6acl7b 58 45 space space NN cord-321150-ev6acl7b 58 46 of of IN cord-321150-ev6acl7b 58 47 informative informative JJ cord-321150-ev6acl7b 58 48 - - HYPH cord-321150-ev6acl7b 58 49 site site NN cord-321150-ev6acl7b 58 50 arrangements arrangement NNS cord-321150-ev6acl7b 58 51 and and CC cord-321150-ev6acl7b 58 52 the the DT cord-321150-ev6acl7b 58 53 space space NN cord-321150-ev6acl7b 58 54 of of IN cord-321150-ev6acl7b 58 55 hypergeometric hypergeometric JJ cord-321150-ev6acl7b 58 56 random random JJ cord-321150-ev6acl7b 58 57 walks walk NNS cord-321150-ev6acl7b 58 58 . . . cord-321150-ev6acl7b 59 1 ( ( -LRB- cord-321150-ev6acl7b 59 2 A a NN cord-321150-ev6acl7b 59 3 ) ) -RRB- cord-321150-ev6acl7b 59 4 A a DT cord-321150-ev6acl7b 59 5 random random JJ cord-321150-ev6acl7b 59 6 arrangement arrangement NN cord-321150-ev6acl7b 59 7 of of IN cord-321150-ev6acl7b 59 8 informative informative JJ cord-321150-ev6acl7b 59 9 sites site NNS cord-321150-ev6acl7b 59 10 , , , cord-321150-ev6acl7b 59 11 which which WDT cord-321150-ev6acl7b 59 12 does do VBZ cord-321150-ev6acl7b 59 13 not not RB cord-321150-ev6acl7b 59 14 visually visually RB cord-321150-ev6acl7b 59 15 suggest suggest VB cord-321150-ev6acl7b 59 16 that that IN cord-321150-ev6acl7b 59 17 the the DT cord-321150-ev6acl7b 59 18 sequence sequence NN cord-321150-ev6acl7b 59 19 is be VBZ cord-321150-ev6acl7b 59 20 a a DT cord-321150-ev6acl7b 59 21 mosaic mosaic NN cord-321150-ev6acl7b 59 22 of of IN cord-321150-ev6acl7b 59 23 putative putative JJ cord-321150-ev6acl7b 59 24 parents parent NNS cord-321150-ev6acl7b 59 25 P p NN cord-321150-ev6acl7b 59 26 and and CC cord-321150-ev6acl7b 59 27 Q. Q. NNP cord-321150-ev6acl7b 60 1 The the DT cord-321150-ev6acl7b 60 2 arrangement arrangement NN cord-321150-ev6acl7b 60 3 of of IN cord-321150-ev6acl7b 60 4 sites site NNS cord-321150-ev6acl7b 60 5 maps map NNS cord-321150-ev6acl7b 60 6 to to IN cord-321150-ev6acl7b 60 7 a a DT cord-321150-ev6acl7b 60 8 random random JJ cord-321150-ev6acl7b 60 9 walk walk NN cord-321150-ev6acl7b 60 10 which which WDT cord-321150-ev6acl7b 60 11 stays stay VBZ cord-321150-ev6acl7b 60 12 fairly fairly RB cord-321150-ev6acl7b 60 13 close close JJ cord-321150-ev6acl7b 60 14 to to IN cord-321150-ev6acl7b 60 15 the the DT cord-321150-ev6acl7b 60 16 horizontal horizontal JJ cord-321150-ev6acl7b 60 17 axis axis NN cord-321150-ev6acl7b 60 18 . . . cord-321150-ev6acl7b 61 1 This this DT cord-321150-ev6acl7b 61 2 walk walk NN cord-321150-ev6acl7b 61 3 's 's POS cord-321150-ev6acl7b 61 4 maximum maximum JJ cord-321150-ev6acl7b 61 5 descent descent NN cord-321150-ev6acl7b 61 6 is be VBZ cord-321150-ev6acl7b 61 7 eight eight CD cord-321150-ev6acl7b 61 8 steps step NNS cord-321150-ev6acl7b 61 9 , , , cord-321150-ev6acl7b 61 10 and and CC cord-321150-ev6acl7b 61 11 $ $ $ cord-321150-ev6acl7b 61 12 54 54 CD cord-321150-ev6acl7b 61 13 % % NN cord-321150-ev6acl7b 61 14 of of IN cord-321150-ev6acl7b 61 15 HGRWs hgrw NNS cord-321150-ev6acl7b 61 16 with with IN cord-321150-ev6acl7b 61 17 30 30 CD cord-321150-ev6acl7b 61 18 up up NN cord-321150-ev6acl7b 61 19 - - HYPH cord-321150-ev6acl7b 61 20 steps step NNS cord-321150-ev6acl7b 61 21 and and CC cord-321150-ev6acl7b 61 22 30 30 CD cord-321150-ev6acl7b 61 23 down down RB cord-321150-ev6acl7b 61 24 - - HYPH cord-321150-ev6acl7b 61 25 steps step NNS cord-321150-ev6acl7b 61 26 have have VBP cord-321150-ev6acl7b 61 27 a a DT cord-321150-ev6acl7b 61 28 maximum maximum JJ cord-321150-ev6acl7b 61 29 descent descent NN cord-321150-ev6acl7b 61 30 of of IN cord-321150-ev6acl7b 61 31 eight eight CD cord-321150-ev6acl7b 61 32 steps step NNS cord-321150-ev6acl7b 61 33 or or CC cord-321150-ev6acl7b 61 34 greater great JJR cord-321150-ev6acl7b 61 35 . . . cord-321150-ev6acl7b 62 1 ( ( -LRB- cord-321150-ev6acl7b 62 2 B b NN cord-321150-ev6acl7b 62 3 ) ) -RRB- cord-321150-ev6acl7b 62 4 A a DT cord-321150-ev6acl7b 62 5 nonrandom nonrandom JJ cord-321150-ev6acl7b 62 6 arrangement arrangement NN cord-321150-ev6acl7b 62 7 of of IN cord-321150-ev6acl7b 62 8 informative informative JJ cord-321150-ev6acl7b 62 9 sites site NNS cord-321150-ev6acl7b 62 10 that that WDT cord-321150-ev6acl7b 62 11 clearly clearly RB cord-321150-ev6acl7b 62 12 suggests suggest VBZ cord-321150-ev6acl7b 62 13 that that IN cord-321150-ev6acl7b 62 14 the the DT cord-321150-ev6acl7b 62 15 candidate candidate NN cord-321150-ev6acl7b 62 16 sequence sequence NN cord-321150-ev6acl7b 62 17 is be VBZ cord-321150-ev6acl7b 62 18 a a DT cord-321150-ev6acl7b 62 19 mosaic mosaic NN cord-321150-ev6acl7b 62 20 of of IN cord-321150-ev6acl7b 62 21 the the DT cord-321150-ev6acl7b 62 22 two two CD cord-321150-ev6acl7b 62 23 parental parental JJ cord-321150-ev6acl7b 62 24 sequences sequence NNS cord-321150-ev6acl7b 62 25 P p NN cord-321150-ev6acl7b 62 26 and and CC cord-321150-ev6acl7b 62 27 Q. Q. NNP cord-321150-ev6acl7b 63 1 The the DT cord-321150-ev6acl7b 63 2 probability probability NN cord-321150-ev6acl7b 63 3 of of IN cord-321150-ev6acl7b 63 4 all all PDT cord-321150-ev6acl7b 63 5 the the DT cord-321150-ev6acl7b 63 6 red red JJ cord-321150-ev6acl7b 63 7 sites site NNS cord-321150-ev6acl7b 63 8 appearing appear VBG cord-321150-ev6acl7b 63 9 consecutively consecutively RB cord-321150-ev6acl7b 63 10 is be VBZ cord-321150-ev6acl7b 63 11 31 31 CD cord-321150-ev6acl7b 63 12 ! ! . cord-321150-ev6acl7b 64 1 Â â NN cord-321150-ev6acl7b 64 2 30!/60 30!/60 CD cord-321150-ev6acl7b 64 3 ! ! . cord-321150-ev6acl7b 65 1 which which WDT cord-321150-ev6acl7b 65 2 is be VBZ cord-321150-ev6acl7b 65 3 2.62 2.62 CD cord-321150-ev6acl7b 65 4 Â â CD cord-321150-ev6acl7b 65 5 10 10 CD cord-321150-ev6acl7b 65 6 À16 À16 NNP cord-321150-ev6acl7b 65 7 . . . cord-321150-ev6acl7b 66 1 ( ( -LRB- cord-321150-ev6acl7b 66 2 C C NNP cord-321150-ev6acl7b 66 3 ) ) -RRB- cord-321150-ev6acl7b 67 1 An an DT cord-321150-ev6acl7b 67 2 arrangement arrangement NN cord-321150-ev6acl7b 67 3 of of IN cord-321150-ev6acl7b 67 4 red red JJ cord-321150-ev6acl7b 67 5 sites site NNS cord-321150-ev6acl7b 67 6 and and CC cord-321150-ev6acl7b 67 7 blue blue JJ cord-321150-ev6acl7b 67 8 sites site NNS cord-321150-ev6acl7b 67 9 that that WDT cord-321150-ev6acl7b 67 10 suggests suggest VBZ cord-321150-ev6acl7b 67 11 the the DT cord-321150-ev6acl7b 67 12 red red JJ cord-321150-ev6acl7b 67 13 sites site NNS cord-321150-ev6acl7b 67 14 may may MD cord-321150-ev6acl7b 67 15 be be VB cord-321150-ev6acl7b 67 16 clustered cluster VBN cord-321150-ev6acl7b 67 17 in in IN cord-321150-ev6acl7b 67 18 the the DT cord-321150-ev6acl7b 67 19 middle middle NN cord-321150-ev6acl7b 67 20 . . . cord-321150-ev6acl7b 68 1 When when WRB cord-321150-ev6acl7b 68 2 mapping map VBG cord-321150-ev6acl7b 68 3 the the DT cord-321150-ev6acl7b 68 4 site site NN cord-321150-ev6acl7b 68 5 arrangement arrangement NN cord-321150-ev6acl7b 68 6 to to IN cord-321150-ev6acl7b 68 7 a a DT cord-321150-ev6acl7b 68 8 hypergeometric hypergeometric JJ cord-321150-ev6acl7b 68 9 random random JJ cord-321150-ev6acl7b 68 10 walk walk NN cord-321150-ev6acl7b 68 11 , , , cord-321150-ev6acl7b 68 12 the the DT cord-321150-ev6acl7b 68 13 random random JJ cord-321150-ev6acl7b 68 14 walk walk NN cord-321150-ev6acl7b 68 15 has have VBZ cord-321150-ev6acl7b 68 16 a a DT cord-321150-ev6acl7b 68 17 maximum maximum JJ cord-321150-ev6acl7b 68 18 descent descent NN cord-321150-ev6acl7b 68 19 of of IN cord-321150-ev6acl7b 68 20 18 18 CD cord-321150-ev6acl7b 68 21 steps step NNS cord-321150-ev6acl7b 68 22 . . . cord-321150-ev6acl7b 69 1 The the DT cord-321150-ev6acl7b 69 2 P p NN cord-321150-ev6acl7b 69 3 value value NN cord-321150-ev6acl7b 69 4 for for IN cord-321150-ev6acl7b 69 5 a a DT cord-321150-ev6acl7b 69 6 maximum maximum JJ cord-321150-ev6acl7b 69 7 descent descent NN cord-321150-ev6acl7b 69 8 of of IN cord-321150-ev6acl7b 69 9 18 18 CD cord-321150-ev6acl7b 69 10 steps step NNS cord-321150-ev6acl7b 69 11 can can MD cord-321150-ev6acl7b 69 12 not not RB cord-321150-ev6acl7b 69 13 be be VB cord-321150-ev6acl7b 69 14 written write VBN cord-321150-ev6acl7b 69 15 down down RP cord-321150-ev6acl7b 69 16 in in IN cord-321150-ev6acl7b 69 17 closed closed JJ cord-321150-ev6acl7b 69 18 form form NN cord-321150-ev6acl7b 69 19 but but CC cord-321150-ev6acl7b 69 20 can can MD cord-321150-ev6acl7b 69 21 be be VB cord-321150-ev6acl7b 69 22 calculated calculate VBN cord-321150-ev6acl7b 69 23 from from IN cord-321150-ev6acl7b 69 24 recursion recursion NN cord-321150-ev6acl7b 69 25 ( ( -LRB- cord-321150-ev6acl7b 69 26 4 4 CD cord-321150-ev6acl7b 69 27 ) ) -RRB- cord-321150-ev6acl7b 69 28 . . . cord-321150-ev6acl7b 70 1 The the DT cord-321150-ev6acl7b 70 2 P p NN cord-321150-ev6acl7b 70 3 value value NN cord-321150-ev6acl7b 70 4 for for IN cord-321150-ev6acl7b 70 5 this this DT cord-321150-ev6acl7b 70 6 maximum maximum JJ cord-321150-ev6acl7b 70 7 descent descent NN cord-321150-ev6acl7b 70 8 and and CC cord-321150-ev6acl7b 70 9 for for IN cord-321150-ev6acl7b 70 10 this this DT cord-321150-ev6acl7b 70 11 arrangement arrangement NN cord-321150-ev6acl7b 70 12 of of IN cord-321150-ev6acl7b 70 13 informative informative JJ cord-321150-ev6acl7b 70 14 sites site NNS cord-321150-ev6acl7b 70 15 is be VBZ cord-321150-ev6acl7b 70 16 1.8 1.8 CD cord-321150-ev6acl7b 70 17 Â â CD cord-321150-ev6acl7b 70 18 10 10 CD cord-321150-ev6acl7b 70 19 À4 à4 NN cord-321150-ev6acl7b 70 20 . . . cord-321150-ev6acl7b 71 1 Lam Lam NNP cord-321150-ev6acl7b 71 2 et et NNP cord-321150-ev6acl7b 71 3 al al NNP cord-321150-ev6acl7b 71 4 . . . cord-321150-ev6acl7b 71 5 . . . cord-321150-ev6acl7b 72 1 doi:10.1093 doi:10.1093 NNP cord-321150-ev6acl7b 72 2 / / SYM cord-321150-ev6acl7b 72 3 molbev molbev NNP cord-321150-ev6acl7b 72 4 / / SYM cord-321150-ev6acl7b 72 5 msx263 msx263 NNP cord-321150-ev6acl7b 72 6 MBE MBE NNP cord-321150-ev6acl7b 72 7 breakpoint breakpoint NN cord-321150-ev6acl7b 72 8 searches search NNS cord-321150-ev6acl7b 72 9 , , , cord-321150-ev6acl7b 72 10 and and CC cord-321150-ev6acl7b 72 11 2 2 LS cord-321150-ev6acl7b 72 12 ) ) -RRB- cord-321150-ev6acl7b 72 13 a a DT cord-321150-ev6acl7b 72 14 repeated repeat VBN cord-321150-ev6acl7b 72 15 subsampling subsampling NN cord-321150-ev6acl7b 72 16 feature feature NN cord-321150-ev6acl7b 72 17 that that WDT cord-321150-ev6acl7b 72 18 allows allow VBZ cord-321150-ev6acl7b 72 19 for for IN cord-321150-ev6acl7b 72 20 comparison comparison NN cord-321150-ev6acl7b 72 21 of of IN cord-321150-ev6acl7b 72 22 data datum NNS cord-321150-ev6acl7b 72 23 sets set NNS cord-321150-ev6acl7b 72 24 of of IN cord-321150-ev6acl7b 72 25 different different JJ cord-321150-ev6acl7b 72 26 sizes size NNS cord-321150-ev6acl7b 73 1 ; ; : cord-321150-ev6acl7b 73 2 with with IN cord-321150-ev6acl7b 73 3 this this DT cord-321150-ev6acl7b 73 4 feature feature NN cord-321150-ev6acl7b 73 5 one one PRP cord-321150-ev6acl7b 73 6 can can MD cord-321150-ev6acl7b 73 7 randomly randomly RB cord-321150-ev6acl7b 73 8 subsample subsample VB cord-321150-ev6acl7b 73 9 M M NNP cord-321150-ev6acl7b 73 10 sequences sequence NNS cord-321150-ev6acl7b 73 11 from from IN cord-321150-ev6acl7b 73 12 multiple multiple JJ cord-321150-ev6acl7b 73 13 databases database NNS cord-321150-ev6acl7b 73 14 or or CC cord-321150-ev6acl7b 73 15 sequence sequence NN cord-321150-ev6acl7b 73 16 collections collection NNS cord-321150-ev6acl7b 73 17 , , , cord-321150-ev6acl7b 73 18 and and CC cord-321150-ev6acl7b 73 19 repeat repeat VB cord-321150-ev6acl7b 73 20 the the DT cord-321150-ev6acl7b 73 21 process process NN cord-321150-ev6acl7b 73 22 to to TO cord-321150-ev6acl7b 73 23 see see VB cord-321150-ev6acl7b 73 24 how how WRB cord-321150-ev6acl7b 73 25 often often RB cord-321150-ev6acl7b 73 26 these these DT cord-321150-ev6acl7b 73 27 subsets subset NNS cord-321150-ev6acl7b 73 28 exhibit exhibit VBP cord-321150-ev6acl7b 73 29 recombination recombination NN cord-321150-ev6acl7b 73 30 . . . cord-321150-ev6acl7b 74 1 The the DT cord-321150-ev6acl7b 74 2 new new JJ cord-321150-ev6acl7b 74 3 source source NN cord-321150-ev6acl7b 74 4 code code NN cord-321150-ev6acl7b 74 5 and and CC cord-321150-ev6acl7b 74 6 manual manual NN cord-321150-ev6acl7b 74 7 can can MD cord-321150-ev6acl7b 74 8 be be VB cord-321150-ev6acl7b 74 9 downloaded download VBN cord-321150-ev6acl7b 74 10 from from IN cord-321150-ev6acl7b 74 11 http://mol.ax/3seq http://mol.ax/3seq NNP cord-321150-ev6acl7b 74 12 . . . cord-321150-ev6acl7b 75 1 When when WRB cord-321150-ev6acl7b 75 2 a a DT cord-321150-ev6acl7b 75 3 P p NN cord-321150-ev6acl7b 75 4 value value NN cord-321150-ev6acl7b 75 5 falls fall VBZ cord-321150-ev6acl7b 75 6 outside outside IN cord-321150-ev6acl7b 75 7 the the DT cord-321150-ev6acl7b 75 8 bounds bound NNS cord-321150-ev6acl7b 75 9 of of IN cord-321150-ev6acl7b 75 10 the the DT cord-321150-ev6acl7b 75 11 table table NN cord-321150-ev6acl7b 75 12 being be VBG cord-321150-ev6acl7b 75 13 used use VBN cord-321150-ev6acl7b 75 14 , , , cord-321150-ev6acl7b 75 15 the the DT cord-321150-ev6acl7b 75 16 software software NN cord-321150-ev6acl7b 75 17 substitutes substitute NNS cord-321150-ev6acl7b 75 18 in in IN cord-321150-ev6acl7b 75 19 Hogan Hogan NNP cord-321150-ev6acl7b 75 20 - - HYPH cord-321150-ev6acl7b 75 21 Siegmund Siegmund NNP cord-321150-ev6acl7b 75 22 approximations approximation NNS cord-321150-ev6acl7b 75 23 ( ( -LRB- cord-321150-ev6acl7b 75 24 Hogan Hogan NNP cord-321150-ev6acl7b 75 25 and and CC cord-321150-ev6acl7b 75 26 Siegmund Siegmund NNP cord-321150-ev6acl7b 75 27 1986 1986 CD cord-321150-ev6acl7b 75 28 ) ) -RRB- cord-321150-ev6acl7b 75 29 for for IN cord-321150-ev6acl7b 75 30 the the DT cord-321150-ev6acl7b 75 31 queried query VBN cord-321150-ev6acl7b 75 32 P p NN cord-321150-ev6acl7b 75 33 value value NN cord-321150-ev6acl7b 75 34 . . . cord-321150-ev6acl7b 76 1 The the DT cord-321150-ev6acl7b 76 2 3SEQ 3seq CD cord-321150-ev6acl7b 76 3 maximum maximum JJ cord-321150-ev6acl7b 76 4 descent descent NN cord-321150-ev6acl7b 76 5 statistic statistic NN cord-321150-ev6acl7b 76 6 describes describe VBZ cord-321150-ev6acl7b 76 7 clustering clustering NN cord-321150-ev6acl7b 76 8 patterns pattern NNS cord-321150-ev6acl7b 76 9 in in IN cord-321150-ev6acl7b 76 10 sequences sequence NNS cord-321150-ev6acl7b 76 11 of of IN cord-321150-ev6acl7b 76 12 binary binary JJ cord-321150-ev6acl7b 76 13 outcomes outcome NNS cord-321150-ev6acl7b 76 14 , , , cord-321150-ev6acl7b 76 15 and and CC cord-321150-ev6acl7b 76 16 is be VBZ cord-321150-ev6acl7b 76 17 therefore therefore RB cord-321150-ev6acl7b 76 18 not not RB cord-321150-ev6acl7b 76 19 confined confine VBN cord-321150-ev6acl7b 76 20 to to IN cord-321150-ev6acl7b 76 21 recombination recombination NN cord-321150-ev6acl7b 76 22 analysis analysis NN cord-321150-ev6acl7b 76 23 . . . cord-321150-ev6acl7b 77 1 The the DT cord-321150-ev6acl7b 77 2 statistic statistic NN cord-321150-ev6acl7b 77 3 can can MD cord-321150-ev6acl7b 77 4 be be VB cord-321150-ev6acl7b 77 5 viewed view VBN cord-321150-ev6acl7b 77 6 as as IN cord-321150-ev6acl7b 77 7 a a DT cord-321150-ev6acl7b 77 8 generalization generalization NN cord-321150-ev6acl7b 77 9 of of IN cord-321150-ev6acl7b 77 10 the the DT cord-321150-ev6acl7b 77 11 Mann Mann NNP cord-321150-ev6acl7b 77 12 - - HYPH cord-321150-ev6acl7b 77 13 Whitney Whitney NNP cord-321150-ev6acl7b 77 14 U U NNP cord-321150-ev6acl7b 77 15 statistic statistic NN cord-321150-ev6acl7b 77 16 , , , cord-321150-ev6acl7b 77 17 in in IN cord-321150-ev6acl7b 77 18 the the DT cord-321150-ev6acl7b 77 19 sense sense NN cord-321150-ev6acl7b 77 20 that that IN cord-321150-ev6acl7b 77 21 outcomes outcome NNS cord-321150-ev6acl7b 77 22 of of IN cord-321150-ev6acl7b 77 23 one one CD cord-321150-ev6acl7b 77 24 type type NN cord-321150-ev6acl7b 77 25 ( ( -LRB- cord-321150-ev6acl7b 77 26 of of IN cord-321150-ev6acl7b 77 27 a a DT cord-321150-ev6acl7b 77 28 binary binary JJ cord-321150-ev6acl7b 77 29 outcome outcome NN cord-321150-ev6acl7b 77 30 variable variable NN cord-321150-ev6acl7b 77 31 ) ) -RRB- cord-321150-ev6acl7b 77 32 do do VBP cord-321150-ev6acl7b 77 33 not not RB cord-321150-ev6acl7b 77 34 necessarily necessarily RB cord-321150-ev6acl7b 77 35 have have VB cord-321150-ev6acl7b 77 36 to to TO cord-321150-ev6acl7b 77 37 cluster cluster VB cord-321150-ev6acl7b 77 38 or or CC cord-321150-ev6acl7b 77 39 rank rank VB cord-321150-ev6acl7b 77 40 at at IN cord-321150-ev6acl7b 77 41 the the DT cord-321150-ev6acl7b 77 42 beginning beginning NN cord-321150-ev6acl7b 77 43 or or CC cord-321150-ev6acl7b 77 44 end end NN cord-321150-ev6acl7b 77 45 of of IN cord-321150-ev6acl7b 77 46 a a DT cord-321150-ev6acl7b 77 47 sequence sequence NN cord-321150-ev6acl7b 77 48 of of IN cord-321150-ev6acl7b 77 49 data datum NNS cord-321150-ev6acl7b 77 50 points point NNS cord-321150-ev6acl7b 77 51 . . . cord-321150-ev6acl7b 78 1 The the DT cord-321150-ev6acl7b 78 2 maximum maximum JJ cord-321150-ev6acl7b 78 3 descent descent NN cord-321150-ev6acl7b 78 4 of of IN cord-321150-ev6acl7b 78 5 a a DT cord-321150-ev6acl7b 78 6 HGRW HGRW NNP cord-321150-ev6acl7b 78 7 can can MD cord-321150-ev6acl7b 78 8 be be VB cord-321150-ev6acl7b 78 9 used use VBN cord-321150-ev6acl7b 78 10 to to TO cord-321150-ev6acl7b 78 11 describe describe VB cord-321150-ev6acl7b 78 12 the the DT cord-321150-ev6acl7b 78 13 clustering clustering NN cord-321150-ev6acl7b 78 14 of of IN cord-321150-ev6acl7b 78 15 one one CD cord-321150-ev6acl7b 78 16 particular particular JJ cord-321150-ev6acl7b 78 17 binary binary JJ cord-321150-ev6acl7b 78 18 outcome outcome NN cord-321150-ev6acl7b 78 19 in in IN cord-321150-ev6acl7b 78 20 the the DT cord-321150-ev6acl7b 78 21 middle middle NN cord-321150-ev6acl7b 78 22 of of IN cord-321150-ev6acl7b 78 23 a a DT cord-321150-ev6acl7b 78 24 sequence sequence NN cord-321150-ev6acl7b 78 25 of of IN cord-321150-ev6acl7b 78 26 binary binary JJ cord-321150-ev6acl7b 78 27 outcomes outcome NNS cord-321150-ev6acl7b 78 28 ; ; : cord-321150-ev6acl7b 78 29 in in IN cord-321150-ev6acl7b 78 30 other other JJ cord-321150-ev6acl7b 78 31 words word NNS cord-321150-ev6acl7b 78 32 , , , cord-321150-ev6acl7b 78 33 it -PRON- PRP cord-321150-ev6acl7b 78 34 is be VBZ cord-321150-ev6acl7b 78 35 a a DT cord-321150-ev6acl7b 78 36 1D 1d CD cord-321150-ev6acl7b 78 37 nonparametric nonparametric JJ cord-321150-ev6acl7b 78 38 clustering clustering NN cord-321150-ev6acl7b 78 39 statistic statistic NN cord-321150-ev6acl7b 78 40 . . . cord-321150-ev6acl7b 79 1 In in IN cord-321150-ev6acl7b 79 2 recombination recombination NN cord-321150-ev6acl7b 79 3 analysis analysis NN cord-321150-ev6acl7b 79 4 , , , cord-321150-ev6acl7b 79 5 this this DT cord-321150-ev6acl7b 79 6 is be VBZ cord-321150-ev6acl7b 79 7 the the DT cord-321150-ev6acl7b 79 8 clustering clustering NN cord-321150-ev6acl7b 79 9 of of IN cord-321150-ev6acl7b 79 10 one one CD cord-321150-ev6acl7b 79 11 kind kind NN cord-321150-ev6acl7b 79 12 of of RB cord-321150-ev6acl7b 79 13 informative informative JJ cord-321150-ev6acl7b 79 14 site site NN cord-321150-ev6acl7b 79 15 among among IN cord-321150-ev6acl7b 79 16 all all PDT cord-321150-ev6acl7b 79 17 the the DT cord-321150-ev6acl7b 79 18 informative informative JJ cord-321150-ev6acl7b 79 19 sites site NNS cord-321150-ev6acl7b 79 20 ( ( -LRB- cord-321150-ev6acl7b 79 21 Han Han NNP cord-321150-ev6acl7b 79 22 et et NNP cord-321150-ev6acl7b 79 23 al al NNP cord-321150-ev6acl7b 79 24 . . NNP cord-321150-ev6acl7b 79 25 2010 2010 CD cord-321150-ev6acl7b 79 26 ) ) -RRB- cord-321150-ev6acl7b 79 27 . . . cord-321150-ev6acl7b 80 1 To to TO cord-321150-ev6acl7b 80 2 make make VB cord-321150-ev6acl7b 80 3 use use NN cord-321150-ev6acl7b 80 4 of of IN cord-321150-ev6acl7b 80 5 this this DT cord-321150-ev6acl7b 80 6 statistic statistic NN cord-321150-ev6acl7b 80 7 easier easy JJR cord-321150-ev6acl7b 80 8 for for IN cord-321150-ev6acl7b 80 9 those those DT cord-321150-ev6acl7b 80 10 working work VBG cord-321150-ev6acl7b 80 11 outside outside IN cord-321150-ev6acl7b 80 12 the the DT cord-321150-ev6acl7b 80 13 field field NN cord-321150-ev6acl7b 80 14 of of IN cord-321150-ev6acl7b 80 15 recombination recombination NN cord-321150-ev6acl7b 80 16 , , , cord-321150-ev6acl7b 80 17 we -PRON- PRP cord-321150-ev6acl7b 80 18 developed develop VBD cord-321150-ev6acl7b 80 19 a a DT cord-321150-ev6acl7b 80 20 web web NN cord-321150-ev6acl7b 80 21 calculator calculator NN cord-321150-ev6acl7b 80 22 ( ( -LRB- cord-321150-ev6acl7b 80 23 fig fig NN cord-321150-ev6acl7b 80 24 . . NNP cord-321150-ev6acl7b 80 25 2 2 LS cord-321150-ev6acl7b 80 26 ) ) -RRB- cord-321150-ev6acl7b 80 27 that that WDT cord-321150-ev6acl7b 80 28 computes compute VBZ cord-321150-ev6acl7b 80 29 exact exact JJ cord-321150-ev6acl7b 80 30 P p NN cord-321150-ev6acl7b 80 31 values value NNS cord-321150-ev6acl7b 80 32 for for IN cord-321150-ev6acl7b 80 33 clustering cluster VBG cord-321150-ev6acl7b 80 34 in in IN cord-321150-ev6acl7b 80 35 a a DT cord-321150-ev6acl7b 80 36 sequence sequence NN cord-321150-ev6acl7b 80 37 of of IN cord-321150-ev6acl7b 80 38 binary binary JJ cord-321150-ev6acl7b 80 39 outcomes outcome NNS cord-321150-ev6acl7b 80 40 , , , cord-321150-ev6acl7b 80 41 available available JJ cord-321150-ev6acl7b 80 42 at at IN cord-321150-ev6acl7b 80 43 http://mol.ax/delta http://mol.ax/delta NNP cord-321150-ev6acl7b 80 44 . . . cord-321150-ev6acl7b 81 1 For for IN cord-321150-ev6acl7b 81 2 example example NN cord-321150-ev6acl7b 81 3 , , , cord-321150-ev6acl7b 81 4 the the DT cord-321150-ev6acl7b 81 5 sequence sequence NN cord-321150-ev6acl7b 81 6 " " `` cord-321150-ev6acl7b 81 7 AAAAABB AAAAABB NNP cord-321150-ev6acl7b 81 8 BBABBBABBBAAAA BBABBBABBBAAAA NNP cord-321150-ev6acl7b 81 9 " " '' cord-321150-ev6acl7b 81 10 can can MD cord-321150-ev6acl7b 81 11 be be VB cord-321150-ev6acl7b 81 12 typed type VBN cord-321150-ev6acl7b 81 13 in in IN cord-321150-ev6acl7b 81 14 and and CC cord-321150-ev6acl7b 81 15 the the DT cord-321150-ev6acl7b 81 16 calculator calculator NN cord-321150-ev6acl7b 81 17 reports report VBZ cord-321150-ev6acl7b 81 18 that that IN cord-321150-ev6acl7b 81 19 the the DT cord-321150-ev6acl7b 81 20 clustering clustering NN cord-321150-ev6acl7b 81 21 of of IN cord-321150-ev6acl7b 81 22 Bs Bs NNP cord-321150-ev6acl7b 81 23 in in IN cord-321150-ev6acl7b 81 24 the the DT cord-321150-ev6acl7b 81 25 middle middle NN cord-321150-ev6acl7b 81 26 of of IN cord-321150-ev6acl7b 81 27 the the DT cord-321150-ev6acl7b 81 28 sequence sequence NN cord-321150-ev6acl7b 81 29 is be VBZ cord-321150-ev6acl7b 81 30 significant significant JJ cord-321150-ev6acl7b 81 31 at at IN cord-321150-ev6acl7b 81 32 P p NN cord-321150-ev6acl7b 81 33 ¼ ¼ CD cord-321150-ev6acl7b 81 34 0.0055 0.0055 CD cord-321150-ev6acl7b 81 35 . . . cord-321150-ev6acl7b 82 1 We -PRON- PRP cord-321150-ev6acl7b 82 2 list list VBP cord-321150-ev6acl7b 82 3 two two CD cord-321150-ev6acl7b 82 4 practical practical JJ cord-321150-ev6acl7b 82 5 example example NN cord-321150-ev6acl7b 82 6 uses use VBZ cord-321150-ev6acl7b 82 7 of of IN cord-321150-ev6acl7b 82 8 our -PRON- PRP$ cord-321150-ev6acl7b 82 9 nonparametric nonparametric JJ cord-321150-ev6acl7b 82 10 clustering clustering NN cord-321150-ev6acl7b 82 11 statistic statistic NN cord-321150-ev6acl7b 82 12 . . . cord-321150-ev6acl7b 83 1 First first RB cord-321150-ev6acl7b 83 2 , , , cord-321150-ev6acl7b 83 3 seasonality seasonality NN cord-321150-ev6acl7b 83 4 can can MD cord-321150-ev6acl7b 83 5 be be VB cord-321150-ev6acl7b 83 6 assessed assess VBN cord-321150-ev6acl7b 83 7 nonparametrically nonparametrically RB cord-321150-ev6acl7b 83 8 . . . cord-321150-ev6acl7b 84 1 If if IN cord-321150-ev6acl7b 84 2 a a DT cord-321150-ev6acl7b 84 3 particular particular JJ cord-321150-ev6acl7b 84 4 population population NN cord-321150-ev6acl7b 84 5 behavior behavior NN cord-321150-ev6acl7b 84 6 or or CC cord-321150-ev6acl7b 84 7 climatic climatic JJ cord-321150-ev6acl7b 84 8 characteristic characteristic NN cord-321150-ev6acl7b 84 9 ( ( -LRB- cord-321150-ev6acl7b 84 10 e.g. e.g. RB cord-321150-ev6acl7b 84 11 , , , cord-321150-ev6acl7b 84 12 rain rain NN cord-321150-ev6acl7b 84 13 or or CC cord-321150-ev6acl7b 84 14 no no DT cord-321150-ev6acl7b 84 15 rain rain NN cord-321150-ev6acl7b 84 16 ) ) -RRB- cord-321150-ev6acl7b 84 17 can can MD cord-321150-ev6acl7b 84 18 be be VB cord-321150-ev6acl7b 84 19 noted note VBN cord-321150-ev6acl7b 84 20 to to TO cord-321150-ev6acl7b 84 21 occur occur VB cord-321150-ev6acl7b 84 22 or or CC cord-321150-ev6acl7b 84 23 not not RB cord-321150-ev6acl7b 84 24 occur occur VB cord-321150-ev6acl7b 84 25 every every DT cord-321150-ev6acl7b 84 26 day day NN cord-321150-ev6acl7b 84 27 , , , cord-321150-ev6acl7b 84 28 then then RB cord-321150-ev6acl7b 84 29 an an DT cord-321150-ev6acl7b 84 30 ordered order VBN cord-321150-ev6acl7b 84 31 sequence sequence NN cord-321150-ev6acl7b 84 32 of of IN cord-321150-ev6acl7b 84 33 the the DT cord-321150-ev6acl7b 84 34 days day NNS cord-321150-ev6acl7b 84 35 in in IN cord-321150-ev6acl7b 84 36 the the DT cord-321150-ev6acl7b 84 37 year year NN cord-321150-ev6acl7b 84 38 will will MD cord-321150-ev6acl7b 84 39 show show VB cord-321150-ev6acl7b 84 40 if if IN cord-321150-ev6acl7b 84 41 the the DT cord-321150-ev6acl7b 84 42 occurrence occurrence NN cord-321150-ev6acl7b 84 43 of of IN cord-321150-ev6acl7b 84 44 one one CD cord-321150-ev6acl7b 84 45 of of IN cord-321150-ev6acl7b 84 46 the the DT cord-321150-ev6acl7b 84 47 behaviors behavior NNS cord-321150-ev6acl7b 84 48 is be VBZ cord-321150-ev6acl7b 84 49 clustered cluster VBN cord-321150-ev6acl7b 84 50 and and CC cord-321150-ev6acl7b 84 51 thus thus RB cord-321150-ev6acl7b 84 52 if if IN cord-321150-ev6acl7b 84 53 this this DT cord-321150-ev6acl7b 84 54 feature feature NN cord-321150-ev6acl7b 84 55 was be VBD cord-321150-ev6acl7b 84 56 seasonal seasonal JJ cord-321150-ev6acl7b 84 57 in in IN cord-321150-ev6acl7b 84 58 that that DT cord-321150-ev6acl7b 84 59 one one CD cord-321150-ev6acl7b 84 60 year year NN cord-321150-ev6acl7b 84 61 . . . cord-321150-ev6acl7b 85 1 As as IN cord-321150-ev6acl7b 85 2 a a DT cord-321150-ev6acl7b 85 3 second second JJ cord-321150-ev6acl7b 85 4 example example NN cord-321150-ev6acl7b 85 5 , , , cord-321150-ev6acl7b 85 6 when when WRB cord-321150-ev6acl7b 85 7 a a DT cord-321150-ev6acl7b 85 8 process process NN cord-321150-ev6acl7b 85 9 is be VBZ cord-321150-ev6acl7b 85 10 expected expect VBN cord-321150-ev6acl7b 85 11 to to TO cord-321150-ev6acl7b 85 12 behave behave VB cord-321150-ev6acl7b 85 13 at at IN cord-321150-ev6acl7b 85 14 an an DT cord-321150-ev6acl7b 85 15 intermediate intermediate JJ cord-321150-ev6acl7b 85 16 range range NN cord-321150-ev6acl7b 85 17 or or CC cord-321150-ev6acl7b 85 18 when when WRB cord-321150-ev6acl7b 85 19 an an DT cord-321150-ev6acl7b 85 20 observation observation NN cord-321150-ev6acl7b 85 21 is be VBZ cord-321150-ev6acl7b 85 22 expected expect VBN cord-321150-ev6acl7b 85 23 to to TO cord-321150-ev6acl7b 85 24 be be VB cord-321150-ev6acl7b 85 25 made make VBN cord-321150-ev6acl7b 85 26 at at IN cord-321150-ev6acl7b 85 27 intermediate intermediate JJ cord-321150-ev6acl7b 85 28 values value NNS cord-321150-ev6acl7b 85 29 only only RB cord-321150-ev6acl7b 85 30 , , , cord-321150-ev6acl7b 85 31 this this DT cord-321150-ev6acl7b 85 32 pattern pattern NN cord-321150-ev6acl7b 85 33 can can MD cord-321150-ev6acl7b 85 34 be be VB cord-321150-ev6acl7b 85 35 tested test VBN cord-321150-ev6acl7b 85 36 for for IN cord-321150-ev6acl7b 85 37 nonparametrically nonparametrically RB cord-321150-ev6acl7b 85 38 . . . cord-321150-ev6acl7b 86 1 Dengue dengue NN cord-321150-ev6acl7b 86 2 virus virus NN cord-321150-ev6acl7b 86 3 does do VBZ cord-321150-ev6acl7b 86 4 not not RB cord-321150-ev6acl7b 86 5 cause cause VB cord-321150-ev6acl7b 86 6 severity severity NN cord-321150-ev6acl7b 86 7 for for IN cord-321150-ev6acl7b 86 8 all all DT cord-321150-ev6acl7b 86 9 ages age NNS cord-321150-ev6acl7b 86 10 equally equally RB cord-321150-ev6acl7b 86 11 . . . cord-321150-ev6acl7b 87 1 One one PRP cord-321150-ev6acl7b 87 2 's 's POS cord-321150-ev6acl7b 87 3 first first JJ cord-321150-ev6acl7b 87 4 dengue dengue NN cord-321150-ev6acl7b 87 5 infection infection NN cord-321150-ev6acl7b 87 6 , , , cord-321150-ev6acl7b 87 7 occurring occur VBG cord-321150-ev6acl7b 87 8 during during IN cord-321150-ev6acl7b 87 9 childhood childhood NN cord-321150-ev6acl7b 87 10 , , , cord-321150-ev6acl7b 87 11 is be VBZ cord-321150-ev6acl7b 87 12 typically typically RB cord-321150-ev6acl7b 87 13 nonsevere nonsevere JJ cord-321150-ev6acl7b 87 14 ; ; , cord-321150-ev6acl7b 87 15 secondary secondary JJ cord-321150-ev6acl7b 87 16 infections infection NNS cord-321150-ev6acl7b 87 17 , , , cord-321150-ev6acl7b 87 18 seen see VBN cord-321150-ev6acl7b 87 19 in in IN cord-321150-ev6acl7b 87 20 older old JJR cord-321150-ev6acl7b 87 21 children child NNS cord-321150-ev6acl7b 87 22 and and CC cord-321150-ev6acl7b 87 23 teenagers teenager NNS cord-321150-ev6acl7b 87 24 , , , cord-321150-ev6acl7b 87 25 have have VBP cord-321150-ev6acl7b 87 26 a a DT cord-321150-ev6acl7b 87 27 higher high JJR cord-321150-ev6acl7b 87 28 chance chance NN cord-321150-ev6acl7b 87 29 of of IN cord-321150-ev6acl7b 87 30 severity severity NN cord-321150-ev6acl7b 87 31 , , , cord-321150-ev6acl7b 87 32 whereas whereas IN cord-321150-ev6acl7b 87 33 tertiary tertiary JJ cord-321150-ev6acl7b 87 34 and and CC cord-321150-ev6acl7b 87 35 subsequent subsequent JJ cord-321150-ev6acl7b 87 36 infections infection NNS cord-321150-ev6acl7b 87 37 , , , cord-321150-ev6acl7b 87 38 those those DT cord-321150-ev6acl7b 87 39 that that WDT cord-321150-ev6acl7b 87 40 would would MD cord-321150-ev6acl7b 87 41 occur occur VB cord-321150-ev6acl7b 87 42 in in IN cord-321150-ev6acl7b 87 43 older old JJR cord-321150-ev6acl7b 87 44 age age NN cord-321150-ev6acl7b 87 45 groups group NNS cord-321150-ev6acl7b 87 46 , , , cord-321150-ev6acl7b 87 47 are be VBP cord-321150-ev6acl7b 87 48 thought think VBN cord-321150-ev6acl7b 87 49 to to TO cord-321150-ev6acl7b 87 50 be be VB cord-321150-ev6acl7b 87 51 rare rare JJ cord-321150-ev6acl7b 87 52 and/or and/or CC cord-321150-ev6acl7b 87 53 subclinical subclinical JJ cord-321150-ev6acl7b 87 54 ( ( -LRB- cord-321150-ev6acl7b 87 55 Gubler Gubler NNP cord-321150-ev6acl7b 87 56 1998 1998 CD cord-321150-ev6acl7b 87 57 ; ; : cord-321150-ev6acl7b 87 58 Wikramaratna Wikramaratna NNP cord-321150-ev6acl7b 87 59 et et NNP cord-321150-ev6acl7b 87 60 al al NNP cord-321150-ev6acl7b 87 61 . . NNP cord-321150-ev6acl7b 87 62 2010 2010 CD cord-321150-ev6acl7b 87 63 ) ) -RRB- cord-321150-ev6acl7b 87 64 . . . cord-321150-ev6acl7b 88 1 Thus thus RB cord-321150-ev6acl7b 88 2 , , , cord-321150-ev6acl7b 88 3 disease disease NN cord-321150-ev6acl7b 88 4 severity severity NN cord-321150-ev6acl7b 88 5 in in IN cord-321150-ev6acl7b 88 6 a a DT cord-321150-ev6acl7b 88 7 surveillance surveillance NN cord-321150-ev6acl7b 88 8 system system NN cord-321150-ev6acl7b 88 9 should should MD cord-321150-ev6acl7b 88 10 be be VB cord-321150-ev6acl7b 88 11 seen see VBN cord-321150-ev6acl7b 88 12 in in IN cord-321150-ev6acl7b 88 13 the the DT cord-321150-ev6acl7b 88 14 intermediate intermediate JJ cord-321150-ev6acl7b 88 15 age age NN cord-321150-ev6acl7b 88 16 ranges range NNS cord-321150-ev6acl7b 88 17 , , , cord-321150-ev6acl7b 88 18 and and CC cord-321150-ev6acl7b 88 19 this this DT cord-321150-ev6acl7b 88 20 can can MD cord-321150-ev6acl7b 88 21 be be VB cord-321150-ev6acl7b 88 22 tested test VBN cord-321150-ev6acl7b 88 23 for for IN cord-321150-ev6acl7b 88 24 nonparametrically nonparametrically RB cord-321150-ev6acl7b 88 25 by by IN cord-321150-ev6acl7b 88 26 noting note VBG cord-321150-ev6acl7b 88 27 if if IN cord-321150-ev6acl7b 88 28 each each DT cord-321150-ev6acl7b 88 29 age age NN cord-321150-ev6acl7b 88 30 band band NN cord-321150-ev6acl7b 88 31 is be VBZ cord-321150-ev6acl7b 88 32 overrepresented overrepresente VBN cord-321150-ev6acl7b 88 33 or or CC cord-321150-ev6acl7b 88 34 underrepresented underrepresente VBN cord-321150-ev6acl7b 88 35 in in IN cord-321150-ev6acl7b 88 36 the the DT cord-321150-ev6acl7b 88 37 pool pool NN cord-321150-ev6acl7b 88 38 of of IN cord-321150-ev6acl7b 88 39 patients patient NNS cord-321150-ev6acl7b 88 40 experiencing experience VBG cord-321150-ev6acl7b 88 41 dengue dengue NN cord-321150-ev6acl7b 88 42 - - HYPH cord-321150-ev6acl7b 88 43 like like JJ cord-321150-ev6acl7b 88 44 severe severe JJ cord-321150-ev6acl7b 88 45 disease disease NN cord-321150-ev6acl7b 88 46 in in IN cord-321150-ev6acl7b 88 47 a a DT cord-321150-ev6acl7b 88 48 hospital hospital NN cord-321150-ev6acl7b 88 49 . . . cord-321150-ev6acl7b 89 1 In in IN cord-321150-ev6acl7b 89 2 fact fact NN cord-321150-ev6acl7b 89 3 , , , cord-321150-ev6acl7b 89 4 since since IN cord-321150-ev6acl7b 89 5 all all DT cord-321150-ev6acl7b 89 6 that that WDT cord-321150-ev6acl7b 89 7 is be VBZ cord-321150-ev6acl7b 89 8 required require VBN cord-321150-ev6acl7b 89 9 here here RB cord-321150-ev6acl7b 89 10 is be VBZ cord-321150-ev6acl7b 89 11 a a DT cord-321150-ev6acl7b 89 12 symptoms symptom NNS cord-321150-ev6acl7b 89 13 description description NN cord-321150-ev6acl7b 89 14 , , , cord-321150-ev6acl7b 89 15 the the DT cord-321150-ev6acl7b 89 16 identification identification NN cord-321150-ev6acl7b 89 17 of of IN cord-321150-ev6acl7b 89 18 a a DT cord-321150-ev6acl7b 89 19 vulnerable vulnerable JJ cord-321150-ev6acl7b 89 20 age age NN cord-321150-ev6acl7b 89 21 range range NN cord-321150-ev6acl7b 89 22 can can MD cord-321150-ev6acl7b 89 23 be be VB cord-321150-ev6acl7b 89 24 done do VBN cord-321150-ev6acl7b 89 25 for for IN cord-321150-ev6acl7b 89 26 any any DT cord-321150-ev6acl7b 89 27 set set NN cord-321150-ev6acl7b 89 28 of of IN cord-321150-ev6acl7b 89 29 symptoms symptom NNS cord-321150-ev6acl7b 89 30 . . . cord-321150-ev6acl7b 90 1 To to TO cord-321150-ev6acl7b 90 2 illustrate illustrate VB cord-321150-ev6acl7b 90 3 improved improved JJ cord-321150-ev6acl7b 90 4 runtimes runtime NNS cord-321150-ev6acl7b 90 5 and and CC cord-321150-ev6acl7b 90 6 memory memory NN cord-321150-ev6acl7b 90 7 usage usage NN cord-321150-ev6acl7b 90 8 of of IN cord-321150-ev6acl7b 90 9 the the DT cord-321150-ev6acl7b 90 10 new new JJ cord-321150-ev6acl7b 90 11 3SEQ 3seq CD cord-321150-ev6acl7b 90 12 algorithm algorithm NN cord-321150-ev6acl7b 90 13 , , , cord-321150-ev6acl7b 90 14 we -PRON- PRP cord-321150-ev6acl7b 90 15 searched search VBD cord-321150-ev6acl7b 90 16 for for IN cord-321150-ev6acl7b 90 17 recombinants recombinant NNS cord-321150-ev6acl7b 90 18 among among IN cord-321150-ev6acl7b 90 19 large large JJ cord-321150-ev6acl7b 90 20 sequence sequence NN cord-321150-ev6acl7b 90 21 data data NN cord-321150-ev6acl7b 90 22 sets set NNS cord-321150-ev6acl7b 90 23 of of IN cord-321150-ev6acl7b 90 24 dengue dengue NN cord-321150-ev6acl7b 90 25 virus virus NN cord-321150-ev6acl7b 90 26 serotype serotype NN cord-321150-ev6acl7b 90 27 2 2 CD cord-321150-ev6acl7b 90 28 , , , cord-321150-ev6acl7b 90 29 Ebola Ebola NNP cord-321150-ev6acl7b 90 30 virus virus NN cord-321150-ev6acl7b 90 31 , , , cord-321150-ev6acl7b 90 32 the the DT cord-321150-ev6acl7b 90 33 coronavirus coronavirus NN cord-321150-ev6acl7b 90 34 responsible responsible JJ cord-321150-ev6acl7b 90 35 for for IN cord-321150-ev6acl7b 90 36 Middle Middle NNP cord-321150-ev6acl7b 90 37 - - HYPH cord-321150-ev6acl7b 90 38 East East NNP cord-321150-ev6acl7b 90 39 Respiratory Respiratory NNP cord-321150-ev6acl7b 90 40 Syndrome Syndrome NNP cord-321150-ev6acl7b 90 41 ( ( -LRB- cord-321150-ev6acl7b 90 42 MERS MERS NNP cord-321150-ev6acl7b 90 43 ) ) -RRB- cord-321150-ev6acl7b 90 44 and and CC cord-321150-ev6acl7b 90 45 Zika Zika NNP cord-321150-ev6acl7b 90 46 virus virus NN cord-321150-ev6acl7b 90 47 ; ; : cord-321150-ev6acl7b 90 48 see see VB cord-321150-ev6acl7b 90 49 table table NN cord-321150-ev6acl7b 90 50 1 1 CD cord-321150-ev6acl7b 90 51 . . . cord-321150-ev6acl7b 91 1 Full full JJ cord-321150-ev6acl7b 91 2 - - HYPH cord-321150-ev6acl7b 91 3 length length NN cord-321150-ev6acl7b 91 4 Zika Zika NNP cord-321150-ev6acl7b 91 5 virus virus NN cord-321150-ev6acl7b 91 6 sequences sequence NNS cord-321150-ev6acl7b 91 7 were be VBD cord-321150-ev6acl7b 91 8 downloaded download VBN cord-321150-ev6acl7b 91 9 from from IN cord-321150-ev6acl7b 91 10 the the DT cord-321150-ev6acl7b 91 11 NCBI NCBI NNP cord-321150-ev6acl7b 91 12 Viral Viral NNP cord-321150-ev6acl7b 91 13 Variation Variation NNP cord-321150-ev6acl7b 91 14 Resource resource NN cord-321150-ev6acl7b 91 15 ( ( -LRB- cord-321150-ev6acl7b 91 16 Brister Brister NNP cord-321150-ev6acl7b 91 17 et et NNP cord-321150-ev6acl7b 91 18 al al NNP cord-321150-ev6acl7b 91 19 . . NNP cord-321150-ev6acl7b 91 20 2014 2014 CD cord-321150-ev6acl7b 91 21 ) ) -RRB- cord-321150-ev6acl7b 91 22 and and CC cord-321150-ev6acl7b 91 23 aligned align VBN cord-321150-ev6acl7b 91 24 with with IN cord-321150-ev6acl7b 91 25 Muscle muscle NN cord-321150-ev6acl7b 91 26 v3.8 v3.8 NN cord-321150-ev6acl7b 91 27 ( ( -LRB- cord-321150-ev6acl7b 91 28 Edgar Edgar NNP cord-321150-ev6acl7b 91 29 2004 2004 CD cord-321150-ev6acl7b 91 30 ) ) -RRB- cord-321150-ev6acl7b 91 31 . . . cord-321150-ev6acl7b 92 1 Full full JJ cord-321150-ev6acl7b 92 2 - - HYPH cord-321150-ev6acl7b 92 3 length length NN cord-321150-ev6acl7b 92 4 sequences sequence NNS cord-321150-ev6acl7b 92 5 of of IN cord-321150-ev6acl7b 92 6 Ebola Ebola NNP cord-321150-ev6acl7b 92 7 virus virus NN cord-321150-ev6acl7b 92 8 , , , cord-321150-ev6acl7b 92 9 dengue dengue NN cord-321150-ev6acl7b 92 10 virus virus NN cord-321150-ev6acl7b 92 11 serotype serotype NN cord-321150-ev6acl7b 92 12 2 2 CD cord-321150-ev6acl7b 92 13 , , , cord-321150-ev6acl7b 92 14 and and CC cord-321150-ev6acl7b 92 15 the the DT cord-321150-ev6acl7b 92 16 coronavirus coronavirus NN cord-321150-ev6acl7b 92 17 responsible responsible JJ cord-321150-ev6acl7b 92 18 for for IN cord-321150-ev6acl7b 92 19 Middle Middle NNP cord-321150-ev6acl7b 92 20 - - HYPH cord-321150-ev6acl7b 92 21 East East NNP cord-321150-ev6acl7b 92 22 Respiratory Respiratory NNP cord-321150-ev6acl7b 92 23 Syndrome Syndrome NNP cord-321150-ev6acl7b 92 24 ( ( -LRB- cord-321150-ev6acl7b 92 25 MERS MERS NNP cord-321150-ev6acl7b 92 26 ) ) -RRB- cord-321150-ev6acl7b 92 27 were be VBD cord-321150-ev6acl7b 92 28 downloaded download VBN cord-321150-ev6acl7b 92 29 from from IN cord-321150-ev6acl7b 92 30 NCBI NCBI NNP cord-321150-ev6acl7b 92 31 and and CC cord-321150-ev6acl7b 92 32 aligned align VBN cord-321150-ev6acl7b 92 33 with with IN cord-321150-ev6acl7b 92 34 the the DT cord-321150-ev6acl7b 92 35 online online JJ cord-321150-ev6acl7b 92 36 NCBI NCBI NNP cord-321150-ev6acl7b 92 37 alignment alignment NN cord-321150-ev6acl7b 92 38 tools tool NNS cord-321150-ev6acl7b 92 39 . . . cord-321150-ev6acl7b 93 1 Ebola Ebola NNP cord-321150-ev6acl7b 93 2 virus virus NN cord-321150-ev6acl7b 93 3 sequences sequence NNS cord-321150-ev6acl7b 93 4 were be VBD cord-321150-ev6acl7b 93 5 restricted restrict VBN cord-321150-ev6acl7b 93 6 to to IN cord-321150-ev6acl7b 93 7 human human JJ cord-321150-ev6acl7b 93 8 viruses virus NNS cord-321150-ev6acl7b 93 9 sampled sample VBN cord-321150-ev6acl7b 93 10 in in IN cord-321150-ev6acl7b 93 11 Africa Africa NNP cord-321150-ev6acl7b 93 12 after after IN cord-321150-ev6acl7b 93 13 December December NNP cord-321150-ev6acl7b 93 14 1 1 CD cord-321150-ev6acl7b 93 15 , , , cord-321150-ev6acl7b 93 16 2013 2013 CD cord-321150-ev6acl7b 93 17 . . . cord-321150-ev6acl7b 94 1 Dengue dengue NN cord-321150-ev6acl7b 94 2 virus virus NN cord-321150-ev6acl7b 94 3 serotype serotype NN cord-321150-ev6acl7b 94 4 2 2 CD cord-321150-ev6acl7b 94 5 was be VBD cord-321150-ev6acl7b 94 6 chosen choose VBN cord-321150-ev6acl7b 94 7 to to TO cord-321150-ev6acl7b 94 8 include include VB cord-321150-ev6acl7b 94 9 a a DT cord-321150-ev6acl7b 94 10 particularly particularly RB cord-321150-ev6acl7b 94 11 large large JJ cord-321150-ev6acl7b 94 12 and and CC cord-321150-ev6acl7b 94 13 polymorphic polymorphic JJ cord-321150-ev6acl7b 94 14 alignment alignment NN cord-321150-ev6acl7b 94 15 . . . cord-321150-ev6acl7b 95 1 As as IN cord-321150-ev6acl7b 95 2 negative negative JJ cord-321150-ev6acl7b 95 3 controls control NNS cord-321150-ev6acl7b 95 4 , , , cord-321150-ev6acl7b 95 5 we -PRON- PRP cord-321150-ev6acl7b 95 6 considered consider VBD cord-321150-ev6acl7b 95 7 segments segment NNS cord-321150-ev6acl7b 95 8 PB2 PB2 NNP cord-321150-ev6acl7b 95 9 and and CC cord-321150-ev6acl7b 95 10 NS NS NNP cord-321150-ev6acl7b 95 11 from from IN cord-321150-ev6acl7b 95 12 avian avian JJ cord-321150-ev6acl7b 95 13 influenza influenza NN cord-321150-ev6acl7b 95 14 A a DT cord-321150-ev6acl7b 95 15 virus virus NN cord-321150-ev6acl7b 95 16 , , , cord-321150-ev6acl7b 95 17 subtype subtype NN cord-321150-ev6acl7b 95 18 H5N1 H5N1 NNP cord-321150-ev6acl7b 95 19 , , , cord-321150-ev6acl7b 95 20 originally originally RB cord-321150-ev6acl7b 95 21 analyzed analyze VBN cord-321150-ev6acl7b 95 22 in in IN cord-321150-ev6acl7b 95 23 Boni Boni NNP cord-321150-ev6acl7b 95 24 et et FW cord-321150-ev6acl7b 95 25 al al NNP cord-321150-ev6acl7b 95 26 . . . cord-321150-ev6acl7b 96 1 ( ( -LRB- cord-321150-ev6acl7b 96 2 2010 2010 CD cord-321150-ev6acl7b 96 3 ) ) -RRB- cord-321150-ev6acl7b 96 4 ; ; : cord-321150-ev6acl7b 96 5 only only RB cord-321150-ev6acl7b 96 6 sequences sequence NNS cord-321150-ev6acl7b 96 7 from from IN cord-321150-ev6acl7b 96 8 the the DT cord-321150-ev6acl7b 96 9 Influenza Influenza NNP cord-321150-ev6acl7b 96 10 Genome Genome NNP cord-321150-ev6acl7b 96 11 Sequencing Sequencing NNP cord-321150-ev6acl7b 96 12 Project Project NNP cord-321150-ev6acl7b 96 13 were be VBD cord-321150-ev6acl7b 96 14 included include VBN cord-321150-ev6acl7b 96 15 FIG fig NN cord-321150-ev6acl7b 96 16 . . . cord-321150-ev6acl7b 97 1 2 2 LS cord-321150-ev6acl7b 97 2 . . . cord-321150-ev6acl7b 98 1 Screenshot Screenshot NNP cord-321150-ev6acl7b 98 2 of of IN cord-321150-ev6acl7b 98 3 new new JJ cord-321150-ev6acl7b 98 4 online online JJ cord-321150-ev6acl7b 98 5 tool tool NN cord-321150-ev6acl7b 98 6 that that WDT cord-321150-ev6acl7b 98 7 can can MD cord-321150-ev6acl7b 98 8 be be VB cord-321150-ev6acl7b 98 9 used use VBN cord-321150-ev6acl7b 98 10 to to TO cord-321150-ev6acl7b 98 11 calculate calculate VB cord-321150-ev6acl7b 98 12 P p NN cord-321150-ev6acl7b 98 13 values value NNS cord-321150-ev6acl7b 98 14 testing test VBG cord-321150-ev6acl7b 98 15 the the DT cord-321150-ev6acl7b 98 16 hypothesis hypothesis NN cord-321150-ev6acl7b 98 17 of of IN cord-321150-ev6acl7b 98 18 whether whether IN cord-321150-ev6acl7b 98 19 one one CD cord-321150-ev6acl7b 98 20 binary binary JJ cord-321150-ev6acl7b 98 21 outcome outcome NN cord-321150-ev6acl7b 98 22 clusters cluster NNS cord-321150-ev6acl7b 98 23 in in IN cord-321150-ev6acl7b 98 24 the the DT cord-321150-ev6acl7b 98 25 middle middle NN cord-321150-ev6acl7b 98 26 of of IN cord-321150-ev6acl7b 98 27 a a DT cord-321150-ev6acl7b 98 28 ( ( -LRB- cord-321150-ev6acl7b 98 29 1D 1d NN cord-321150-ev6acl7b 98 30 ) ) -RRB- cord-321150-ev6acl7b 98 31 sequence sequence NN cord-321150-ev6acl7b 98 32 of of IN cord-321150-ev6acl7b 98 33 binary binary JJ cord-321150-ev6acl7b 98 34 outcomes outcome NNS cord-321150-ev6acl7b 98 35 . . . cord-321150-ev6acl7b 99 1 One one CD cord-321150-ev6acl7b 99 2 input input NN cord-321150-ev6acl7b 99 3 method method NN cord-321150-ev6acl7b 99 4 is be VBZ cord-321150-ev6acl7b 99 5 simply simply RB cord-321150-ev6acl7b 99 6 typing type VBG cord-321150-ev6acl7b 99 7 two two CD cord-321150-ev6acl7b 99 8 characters character NNS cord-321150-ev6acl7b 99 9 in in IN cord-321150-ev6acl7b 99 10 a a DT cord-321150-ev6acl7b 99 11 text text NN cord-321150-ev6acl7b 99 12 box box NN cord-321150-ev6acl7b 99 13 ( ( -LRB- cord-321150-ev6acl7b 99 14 above above RB cord-321150-ev6acl7b 99 15 , , , cord-321150-ev6acl7b 99 16 " " `` cord-321150-ev6acl7b 99 17 U U NNP cord-321150-ev6acl7b 99 18 " " '' cord-321150-ev6acl7b 99 19 for for IN cord-321150-ev6acl7b 99 20 up up RB cord-321150-ev6acl7b 99 21 and and CC cord-321150-ev6acl7b 99 22 " " `` cord-321150-ev6acl7b 99 23 D D NNP cord-321150-ev6acl7b 99 24 " " '' cord-321150-ev6acl7b 99 25 for for IN cord-321150-ev6acl7b 99 26 down down RB cord-321150-ev6acl7b 99 27 ) ) -RRB- cord-321150-ev6acl7b 99 28 and and CC cord-321150-ev6acl7b 99 29 letting let VBG cord-321150-ev6acl7b 99 30 the the DT cord-321150-ev6acl7b 99 31 calculator calculator NN cord-321150-ev6acl7b 99 32 return return VB cord-321150-ev6acl7b 99 33 a a DT cord-321150-ev6acl7b 99 34 P p NN cord-321150-ev6acl7b 99 35 value value NN cord-321150-ev6acl7b 99 36 showing show VBG cord-321150-ev6acl7b 99 37 whether whether IN cord-321150-ev6acl7b 99 38 one one CD cord-321150-ev6acl7b 99 39 type type NN cord-321150-ev6acl7b 99 40 of of IN cord-321150-ev6acl7b 99 41 character character NN cord-321150-ev6acl7b 99 42 is be VBZ cord-321150-ev6acl7b 99 43 clustered cluster VBN cord-321150-ev6acl7b 99 44 in in IN cord-321150-ev6acl7b 99 45 the the DT cord-321150-ev6acl7b 99 46 middle middle NN cord-321150-ev6acl7b 99 47 . . . cord-321150-ev6acl7b 100 1 To to TO cord-321150-ev6acl7b 100 2 test test VB cord-321150-ev6acl7b 100 3 whether whether IN cord-321150-ev6acl7b 100 4 the the DT cord-321150-ev6acl7b 100 5 other other JJ cord-321150-ev6acl7b 100 6 type type NN cord-321150-ev6acl7b 100 7 of of IN cord-321150-ev6acl7b 100 8 character character NN cord-321150-ev6acl7b 100 9 is be VBZ cord-321150-ev6acl7b 100 10 clustered cluster VBN cord-321150-ev6acl7b 100 11 , , , cord-321150-ev6acl7b 100 12 the the DT cord-321150-ev6acl7b 100 13 " " `` cord-321150-ev6acl7b 100 14 SWAP swap NN cord-321150-ev6acl7b 100 15 " " '' cord-321150-ev6acl7b 100 16 button button NN cord-321150-ev6acl7b 100 17 can can MD cord-321150-ev6acl7b 100 18 be be VB cord-321150-ev6acl7b 100 19 used use VBN cord-321150-ev6acl7b 100 20 . . . cord-321150-ev6acl7b 101 1 The the DT cord-321150-ev6acl7b 101 2 hypergeometric hypergeometric JJ cord-321150-ev6acl7b 101 3 walk walk NN cord-321150-ev6acl7b 101 4 is be VBZ cord-321150-ev6acl7b 101 5 shown show VBN cord-321150-ev6acl7b 101 6 graphically graphically RB cord-321150-ev6acl7b 101 7 . . . cord-321150-ev6acl7b 102 1 The the DT cord-321150-ev6acl7b 102 2 exact exact JJ cord-321150-ev6acl7b 102 3 P p NN cord-321150-ev6acl7b 102 4 value value NN cord-321150-ev6acl7b 102 5 , , , cord-321150-ev6acl7b 102 6 computed compute VBN cord-321150-ev6acl7b 102 7 with with IN cord-321150-ev6acl7b 102 8 the the DT cord-321150-ev6acl7b 102 9 methods method NNS cord-321150-ev6acl7b 102 10 in in IN cord-321150-ev6acl7b 102 11 this this DT cord-321150-ev6acl7b 102 12 article article NN cord-321150-ev6acl7b 102 13 , , , cord-321150-ev6acl7b 102 14 is be VBZ cord-321150-ev6acl7b 102 15 shown show VBN cord-321150-ev6acl7b 102 16 . . . cord-321150-ev6acl7b 103 1 The the DT cord-321150-ev6acl7b 103 2 two two CD cord-321150-ev6acl7b 103 3 Hogan Hogan NNP cord-321150-ev6acl7b 103 4 - - HYPH cord-321150-ev6acl7b 103 5 Siegmund Siegmund NNP cord-321150-ev6acl7b 103 6 approximations approximation NNS cord-321150-ev6acl7b 103 7 for for IN cord-321150-ev6acl7b 103 8 this this DT cord-321150-ev6acl7b 103 9 P p NN cord-321150-ev6acl7b 103 10 value value NN cord-321150-ev6acl7b 103 11 are be VBP cord-321150-ev6acl7b 103 12 also also RB cord-321150-ev6acl7b 103 13 shown show VBN cord-321150-ev6acl7b 103 14 . . . cord-321150-ev6acl7b 104 1 Improved Improved NNP cord-321150-ev6acl7b 104 2 Algorithmic Algorithmic NNP cord-321150-ev6acl7b 104 3 Complexity Complexity NNP cord-321150-ev6acl7b 104 4 for for IN cord-321150-ev6acl7b 104 5 3SEQ 3SEQ NNP cord-321150-ev6acl7b 104 6 . . . cord-321150-ev6acl7b 105 1 doi:10.1093 doi:10.1093 NNP cord-321150-ev6acl7b 105 2 / / SYM cord-321150-ev6acl7b 105 3 molbev molbev NNP cord-321150-ev6acl7b 105 4 / / SYM cord-321150-ev6acl7b 105 5 msx263 msx263 NNP cord-321150-ev6acl7b 105 6 MBE MBE NNP cord-321150-ev6acl7b 106 1 ( ( -LRB- cord-321150-ev6acl7b 106 2 Ghedin Ghedin NNP cord-321150-ev6acl7b 106 3 et et NNP cord-321150-ev6acl7b 106 4 al al NNP cord-321150-ev6acl7b 106 5 . . NNP cord-321150-ev6acl7b 106 6 2005 2005 CD cord-321150-ev6acl7b 106 7 ) ) -RRB- cord-321150-ev6acl7b 106 8 and and CC cord-321150-ev6acl7b 106 9 identical identical JJ cord-321150-ev6acl7b 106 10 sequences sequence NNS cord-321150-ev6acl7b 106 11 were be VBD cord-321150-ev6acl7b 106 12 removed remove VBN cord-321150-ev6acl7b 106 13 ( ( -LRB- cord-321150-ev6acl7b 106 14 when when WRB cord-321150-ev6acl7b 106 15 identical identical JJ cord-321150-ev6acl7b 106 16 sequences sequence NNS cord-321150-ev6acl7b 106 17 were be VBD cord-321150-ev6acl7b 106 18 not not RB cord-321150-ev6acl7b 106 19 removed remove VBN cord-321150-ev6acl7b 106 20 , , , cord-321150-ev6acl7b 106 21 results result NNS cord-321150-ev6acl7b 106 22 using use VBG cord-321150-ev6acl7b 106 23 the the DT cord-321150-ev6acl7b 106 24 new new JJ cord-321150-ev6acl7b 106 25 version version NN cord-321150-ev6acl7b 106 26 of of IN cord-321150-ev6acl7b 106 27 3SEQ 3SEQ NNP cord-321150-ev6acl7b 107 1 were be VBD cord-321150-ev6acl7b 107 2 identical identical JJ cord-321150-ev6acl7b 107 3 to to IN cord-321150-ev6acl7b 107 4 the the DT cord-321150-ev6acl7b 107 5 results result NNS cord-321150-ev6acl7b 107 6 in in IN cord-321150-ev6acl7b 107 7 table table NN cord-321150-ev6acl7b 107 8 1 1 CD cord-321150-ev6acl7b 107 9 of of IN cord-321150-ev6acl7b 107 10 Boni Boni NNP cord-321150-ev6acl7b 107 11 et et FW cord-321150-ev6acl7b 107 12 al al NNP cord-321150-ev6acl7b 107 13 . . NNP cord-321150-ev6acl7b 107 14 2010 2010 CD cord-321150-ev6acl7b 107 15 ) ) -RRB- cord-321150-ev6acl7b 107 16 . . . cord-321150-ev6acl7b 108 1 The the DT cord-321150-ev6acl7b 108 2 new new JJ cord-321150-ev6acl7b 108 3 version version NN cord-321150-ev6acl7b 108 4 of of IN cord-321150-ev6acl7b 108 5 the the DT cord-321150-ev6acl7b 108 6 software software NN cord-321150-ev6acl7b 108 7 - - HYPH cord-321150-ev6acl7b 108 8 run run VBN cord-321150-ev6acl7b 108 9 with with IN cord-321150-ev6acl7b 108 10 a a DT cord-321150-ev6acl7b 108 11 P p NN cord-321150-ev6acl7b 108 12 value value NN cord-321150-ev6acl7b 108 13 table table NN cord-321150-ev6acl7b 108 14 of of IN cord-321150-ev6acl7b 108 15 size size NN cord-321150-ev6acl7b 108 16 1,200 1,200 CD cord-321150-ev6acl7b 108 17 Â â CD cord-321150-ev6acl7b 108 18 1,200 1,200 CD cord-321150-ev6acl7b 108 19 Â â CD cord-321150-ev6acl7b 108 20 1,200-had 1,200-had CD cord-321150-ev6acl7b 108 21 faster fast JJR cord-321150-ev6acl7b 108 22 computation computation NN cord-321150-ev6acl7b 108 23 times time NNS cord-321150-ev6acl7b 108 24 than than IN cord-321150-ev6acl7b 108 25 the the DT cord-321150-ev6acl7b 108 26 previous previous JJ cord-321150-ev6acl7b 108 27 version version NN cord-321150-ev6acl7b 108 28 and and CC cord-321150-ev6acl7b 108 29 was be VBD cord-321150-ev6acl7b 108 30 able able JJ cord-321150-ev6acl7b 108 31 to to TO cord-321150-ev6acl7b 108 32 comfortably comfortably RB cord-321150-ev6acl7b 108 33 accommodate accommodate VB cord-321150-ev6acl7b 108 34 alignments alignment NNS cord-321150-ev6acl7b 108 35 with with IN cord-321150-ev6acl7b 108 36 thousands thousand NNS cord-321150-ev6acl7b 108 37 of of IN cord-321150-ev6acl7b 108 38 polymorphic polymorphic JJ cord-321150-ev6acl7b 108 39 sites site NNS cord-321150-ev6acl7b 108 40 . . . cord-321150-ev6acl7b 109 1 Table table NN cord-321150-ev6acl7b 109 2 1 1 CD cord-321150-ev6acl7b 109 3 shows show VBZ cord-321150-ev6acl7b 109 4 the the DT cord-321150-ev6acl7b 109 5 results result NNS cord-321150-ev6acl7b 109 6 of of IN cord-321150-ev6acl7b 109 7 all all DT cord-321150-ev6acl7b 109 8 runs run NNS cord-321150-ev6acl7b 109 9 . . . cord-321150-ev6acl7b 110 1 Note note VB cord-321150-ev6acl7b 110 2 that that IN cord-321150-ev6acl7b 110 3 because because IN cord-321150-ev6acl7b 110 4 3SEQ 3SEQ NNP cord-321150-ev6acl7b 110 5 evaluates evaluate VBZ cord-321150-ev6acl7b 110 6 all all DT cord-321150-ev6acl7b 110 7 triplets triplet NNS cord-321150-ev6acl7b 110 8 in in IN cord-321150-ev6acl7b 110 9 a a DT cord-321150-ev6acl7b 110 10 data data NN cord-321150-ev6acl7b 110 11 set set NN cord-321150-ev6acl7b 110 12 , , , cord-321150-ev6acl7b 110 13 the the DT cord-321150-ev6acl7b 110 14 run run JJ cord-321150-ev6acl7b 110 15 time time NN cord-321150-ev6acl7b 110 16 of of IN cord-321150-ev6acl7b 110 17 the the DT cord-321150-ev6acl7b 110 18 algorithm algorithm NN cord-321150-ev6acl7b 110 19 scales scale VBZ cord-321150-ev6acl7b 110 20 as as IN cord-321150-ev6acl7b 110 21 the the DT cord-321150-ev6acl7b 110 22 cube cube NN cord-321150-ev6acl7b 110 23 of of IN cord-321150-ev6acl7b 110 24 the the DT cord-321150-ev6acl7b 110 25 number number NN cord-321150-ev6acl7b 110 26 of of IN cord-321150-ev6acl7b 110 27 sequences sequence NNS cord-321150-ev6acl7b 110 28 and and CC cord-321150-ev6acl7b 110 29 linearly linearly RB cord-321150-ev6acl7b 110 30 with with IN cord-321150-ev6acl7b 110 31 the the DT cord-321150-ev6acl7b 110 32 alignment alignment NN cord-321150-ev6acl7b 110 33 length length NN cord-321150-ev6acl7b 110 34 . . . cord-321150-ev6acl7b 111 1 As as IN cord-321150-ev6acl7b 111 2 informative informative JJ cord-321150-ev6acl7b 111 3 sites site NNS cord-321150-ev6acl7b 111 4 can can MD cord-321150-ev6acl7b 111 5 sometimes sometimes RB cord-321150-ev6acl7b 111 6 be be VB cord-321150-ev6acl7b 111 7 clustered cluster VBN cord-321150-ev6acl7b 111 8 in in IN cord-321150-ev6acl7b 111 9 short short JJ cord-321150-ev6acl7b 111 10 regions region NNS cord-321150-ev6acl7b 111 11 of of IN cord-321150-ev6acl7b 111 12 the the DT cord-321150-ev6acl7b 111 13 genome genome NN cord-321150-ev6acl7b 111 14 , , , cord-321150-ev6acl7b 111 15 3SEQ 3SEQ NNP cord-321150-ev6acl7b 111 16 will will MD cord-321150-ev6acl7b 111 17 report report VB cord-321150-ev6acl7b 111 18 these these DT cord-321150-ev6acl7b 111 19 short short JJ cord-321150-ev6acl7b 111 20 segments segment NNS cord-321150-ev6acl7b 111 21 as as IN cord-321150-ev6acl7b 111 22 recombinant recombinant JJ cord-321150-ev6acl7b 111 23 . . . cord-321150-ev6acl7b 112 1 For for IN cord-321150-ev6acl7b 112 2 this this DT cord-321150-ev6acl7b 112 3 reason reason NN cord-321150-ev6acl7b 112 4 , , , cord-321150-ev6acl7b 112 5 an an DT cord-321150-ev6acl7b 112 6 additional additional JJ cord-321150-ev6acl7b 112 7 column column NN cord-321150-ev6acl7b 112 8 is be VBZ cord-321150-ev6acl7b 112 9 included include VBN cord-321150-ev6acl7b 112 10 in in IN cord-321150-ev6acl7b 112 11 table table NN cord-321150-ev6acl7b 112 12 1 1 CD cord-321150-ev6acl7b 112 13 showing show VBG cord-321150-ev6acl7b 112 14 the the DT cord-321150-ev6acl7b 112 15 number number NN cord-321150-ev6acl7b 112 16 of of IN cord-321150-ev6acl7b 112 17 sequences sequence NNS cord-321150-ev6acl7b 112 18 that that WDT cord-321150-ev6acl7b 112 19 were be VBD cord-321150-ev6acl7b 112 20 identified identify VBN cord-321150-ev6acl7b 112 21 as as IN cord-321150-ev6acl7b 112 22 recombinant recombinant JJ cord-321150-ev6acl7b 112 23 with with IN cord-321150-ev6acl7b 112 24 both both DT cord-321150-ev6acl7b 112 25 inherited inherit VBN cord-321150-ev6acl7b 112 26 regions region NNS cord-321150-ev6acl7b 112 27 being be VBG cord-321150-ev6acl7b 112 28 longer long JJR cord-321150-ev6acl7b 112 29 than than IN cord-321150-ev6acl7b 112 30 500 500 CD cord-321150-ev6acl7b 112 31 nt nt RB cord-321150-ev6acl7b 112 32 ; ; : cord-321150-ev6acl7b 112 33 if if IN cord-321150-ev6acl7b 112 34 one one CD cord-321150-ev6acl7b 112 35 of of IN cord-321150-ev6acl7b 112 36 the the DT cord-321150-ev6acl7b 112 37 recombinant recombinant JJ cord-321150-ev6acl7b 112 38 regions region NNS cord-321150-ev6acl7b 112 39 is be VBZ cord-321150-ev6acl7b 112 40 very very RB cord-321150-ev6acl7b 112 41 short short JJ cord-321150-ev6acl7b 112 42 , , , cord-321150-ev6acl7b 112 43 it -PRON- PRP cord-321150-ev6acl7b 112 44 is be VBZ cord-321150-ev6acl7b 112 45 difficult difficult JJ cord-321150-ev6acl7b 112 46 to to TO cord-321150-ev6acl7b 112 47 confirm confirm VB cord-321150-ev6acl7b 112 48 the the DT cord-321150-ev6acl7b 112 49 recombination recombination NN cord-321150-ev6acl7b 112 50 results result NNS cord-321150-ev6acl7b 112 51 with with IN cord-321150-ev6acl7b 112 52 a a DT cord-321150-ev6acl7b 112 53 phylogenetic phylogenetic JJ cord-321150-ev6acl7b 112 54 analysis analysis NN cord-321150-ev6acl7b 112 55 of of IN cord-321150-ev6acl7b 112 56 the the DT cord-321150-ev6acl7b 112 57 two two CD cord-321150-ev6acl7b 112 58 identified identify VBN cord-321150-ev6acl7b 112 59 parental parental JJ cord-321150-ev6acl7b 112 60 segments segment NNS cord-321150-ev6acl7b 112 61 . . . cord-321150-ev6acl7b 113 1 Starting start VBG cord-321150-ev6acl7b 113 2 with with IN cord-321150-ev6acl7b 113 3 the the DT cord-321150-ev6acl7b 113 4 analysis analysis NN cord-321150-ev6acl7b 113 5 on on IN cord-321150-ev6acl7b 113 6 the the DT cord-321150-ev6acl7b 113 7 two two CD cord-321150-ev6acl7b 113 8 negative negative JJ cord-321150-ev6acl7b 113 9 control control NN cord-321150-ev6acl7b 113 10 data data NN cord-321150-ev6acl7b 113 11 sets set NNS cord-321150-ev6acl7b 113 12 , , , cord-321150-ev6acl7b 113 13 no no DT cord-321150-ev6acl7b 113 14 recombinant recombinant JJ cord-321150-ev6acl7b 113 15 segments segment NNS cord-321150-ev6acl7b 113 16 longer long RBR cord-321150-ev6acl7b 113 17 than than IN cord-321150-ev6acl7b 113 18 500 500 CD cord-321150-ev6acl7b 113 19 nt nt RB cord-321150-ev6acl7b 113 20 were be VBD cord-321150-ev6acl7b 113 21 detected detect VBN cord-321150-ev6acl7b 113 22 in in IN cord-321150-ev6acl7b 113 23 either either DT cord-321150-ev6acl7b 113 24 avian avian JJ cord-321150-ev6acl7b 113 25 influenza influenza NN cord-321150-ev6acl7b 113 26 alignment alignment NN cord-321150-ev6acl7b 113 27 . . . cord-321150-ev6acl7b 114 1 Both both DT cord-321150-ev6acl7b 114 2 of of IN cord-321150-ev6acl7b 114 3 these these DT cord-321150-ev6acl7b 114 4 runs run NNS cord-321150-ev6acl7b 114 5 took take VBD cord-321150-ev6acl7b 114 6 < < XX cord-321150-ev6acl7b 114 7 30 30 CD cord-321150-ev6acl7b 114 8 s. s. NNP cord-321150-ev6acl7b 115 1 The the DT cord-321150-ev6acl7b 115 2 genomic genomic JJ cord-321150-ev6acl7b 115 3 alignments alignment NNS cord-321150-ev6acl7b 115 4 of of IN cord-321150-ev6acl7b 115 5 MERS MERS NNPS cord-321150-ev6acl7b 115 6 and and CC cord-321150-ev6acl7b 115 7 Zika Zika NNP cord-321150-ev6acl7b 115 8 virus virus NN cord-321150-ev6acl7b 115 9 contained contain VBD cord-321150-ev6acl7b 115 10 1,150 1,150 CD cord-321150-ev6acl7b 115 11 and and CC cord-321150-ev6acl7b 115 12 2,792 2,792 CD cord-321150-ev6acl7b 115 13 polymorphic polymorphic JJ cord-321150-ev6acl7b 115 14 sites site NNS cord-321150-ev6acl7b 115 15 , , , cord-321150-ev6acl7b 115 16 respectively respectively RB cord-321150-ev6acl7b 115 17 , , , cord-321150-ev6acl7b 115 18 and and CC cord-321150-ev6acl7b 115 19 > > XX cord-321150-ev6acl7b 115 20 99.9 99.9 CD cord-321150-ev6acl7b 115 21 % % NN cord-321150-ev6acl7b 115 22 triplets triplet NNS cord-321150-ev6acl7b 115 23 were be VBD cord-321150-ev6acl7b 115 24 able able JJ cord-321150-ev6acl7b 115 25 to to TO cord-321150-ev6acl7b 115 26 be be VB cord-321150-ev6acl7b 115 27 tested test VBN cord-321150-ev6acl7b 115 28 for for IN cord-321150-ev6acl7b 115 29 mosaicism mosaicism NN cord-321150-ev6acl7b 115 30 with with IN cord-321150-ev6acl7b 115 31 exact exact JJ cord-321150-ev6acl7b 115 32 P p NN cord-321150-ev6acl7b 115 33 values value NNS cord-321150-ev6acl7b 115 34 . . . cord-321150-ev6acl7b 116 1 These these DT cord-321150-ev6acl7b 116 2 runs run NNS cord-321150-ev6acl7b 116 3 took take VBD cord-321150-ev6acl7b 116 4 < < XX cord-321150-ev6acl7b 116 5 2 2 CD cord-321150-ev6acl7b 116 6 min min NN cord-321150-ev6acl7b 116 7 . . . cord-321150-ev6acl7b 117 1 As as IN cord-321150-ev6acl7b 117 2 expected expect VBN cord-321150-ev6acl7b 117 3 from from IN cord-321150-ev6acl7b 117 4 a a DT cord-321150-ev6acl7b 117 5 recent recent JJ cord-321150-ev6acl7b 117 6 analysis analysis NN cord-321150-ev6acl7b 117 7 by by IN cord-321150-ev6acl7b 117 8 Dudas Dudas NNP cord-321150-ev6acl7b 117 9 and and CC cord-321150-ev6acl7b 117 10 Rambaut Rambaut NNP cord-321150-ev6acl7b 117 11 ( ( -LRB- cord-321150-ev6acl7b 117 12 Dudas Dudas NNP cord-321150-ev6acl7b 117 13 and and CC cord-321150-ev6acl7b 117 14 Rambaut Rambaut NNP cord-321150-ev6acl7b 117 15 2015 2015 CD cord-321150-ev6acl7b 117 16 ) ) -RRB- cord-321150-ev6acl7b 117 17 , , , cord-321150-ev6acl7b 117 18 the the DT cord-321150-ev6acl7b 117 19 MERS MERS NNP cord-321150-ev6acl7b 117 20 sequence sequence NN cord-321150-ev6acl7b 117 21 data datum NNS cord-321150-ev6acl7b 117 22 set set NN cord-321150-ev6acl7b 117 23 was be VBD cord-321150-ev6acl7b 117 24 highly highly RB cord-321150-ev6acl7b 117 25 recombinant recombinant JJ cord-321150-ev6acl7b 117 26 , , , cord-321150-ev6acl7b 117 27 with with IN cord-321150-ev6acl7b 117 28 100 100 CD cord-321150-ev6acl7b 117 29 out out IN cord-321150-ev6acl7b 117 30 of of IN cord-321150-ev6acl7b 117 31 164 164 CD cord-321150-ev6acl7b 117 32 sequences sequence NNS cord-321150-ev6acl7b 117 33 being be VBG cord-321150-ev6acl7b 117 34 identified identify VBN cord-321150-ev6acl7b 117 35 as as IN cord-321150-ev6acl7b 117 36 such such JJ cord-321150-ev6acl7b 117 37 . . . cord-321150-ev6acl7b 118 1 For for IN cord-321150-ev6acl7b 118 2 Zika Zika NNP cord-321150-ev6acl7b 118 3 , , , cord-321150-ev6acl7b 118 4 6 6 CD cord-321150-ev6acl7b 118 5 out out IN cord-321150-ev6acl7b 118 6 of of IN cord-321150-ev6acl7b 118 7 157 157 CD cord-321150-ev6acl7b 118 8 virus virus NN cord-321150-ev6acl7b 118 9 sequences sequence NNS cord-321150-ev6acl7b 118 10 were be VBD cord-321150-ev6acl7b 118 11 identified identify VBN cord-321150-ev6acl7b 118 12 as as IN cord-321150-ev6acl7b 118 13 recombinant recombinant JJ cord-321150-ev6acl7b 118 14 , , , cord-321150-ev6acl7b 118 15 consistent consistent JJ cord-321150-ev6acl7b 118 16 with with IN cord-321150-ev6acl7b 118 17 earlier early JJR cord-321150-ev6acl7b 118 18 analyses analysis NNS cord-321150-ev6acl7b 118 19 supporting support VBG cord-321150-ev6acl7b 118 20 the the DT cord-321150-ev6acl7b 118 21 presence presence NN cord-321150-ev6acl7b 118 22 of of IN cord-321150-ev6acl7b 118 23 recombination recombination NN cord-321150-ev6acl7b 118 24 in in IN cord-321150-ev6acl7b 118 25 the the DT cord-321150-ev6acl7b 118 26 evolutionary evolutionary JJ cord-321150-ev6acl7b 118 27 history history NN cord-321150-ev6acl7b 118 28 of of IN cord-321150-ev6acl7b 118 29 Zika Zika NNP cord-321150-ev6acl7b 119 1 ( ( -LRB- cord-321150-ev6acl7b 119 2 Faye Faye NNP cord-321150-ev6acl7b 119 3 et et FW cord-321150-ev6acl7b 119 4 al al NNP cord-321150-ev6acl7b 119 5 . . . cord-321150-ev6acl7b 120 1 2014 2014 CD cord-321150-ev6acl7b 120 2 ; ; : cord-321150-ev6acl7b 120 3 Zhu Zhu NNP cord-321150-ev6acl7b 120 4 et et FW cord-321150-ev6acl7b 120 5 al al NNP cord-321150-ev6acl7b 120 6 . . . cord-321150-ev6acl7b 120 7 2016 2016 CD cord-321150-ev6acl7b 120 8 ) ) -RRB- cord-321150-ev6acl7b 120 9 ; ; : cord-321150-ev6acl7b 121 1 details detail NNS cord-321150-ev6acl7b 121 2 of of IN cord-321150-ev6acl7b 121 3 the the DT cord-321150-ev6acl7b 121 4 recombinants recombinant NNS cord-321150-ev6acl7b 121 5 , , , cord-321150-ev6acl7b 121 6 parents parent NNS cord-321150-ev6acl7b 121 7 , , , cord-321150-ev6acl7b 121 8 and and CC cord-321150-ev6acl7b 121 9 breakpoints breakpoint NNS cord-321150-ev6acl7b 121 10 are be VBP cord-321150-ev6acl7b 121 11 included include VBN cord-321150-ev6acl7b 121 12 in in IN cord-321150-ev6acl7b 121 13 the the DT cord-321150-ev6acl7b 121 14 Supplementary Supplementary NNP cord-321150-ev6acl7b 121 15 Material Material NNP cord-321150-ev6acl7b 121 16 online online RB cord-321150-ev6acl7b 121 17 . . . cord-321150-ev6acl7b 122 1 The the DT cord-321150-ev6acl7b 122 2 Ebola Ebola NNP cord-321150-ev6acl7b 122 3 virus virus NN cord-321150-ev6acl7b 122 4 and and CC cord-321150-ev6acl7b 122 5 dengue dengue NN cord-321150-ev6acl7b 122 6 virus virus NN cord-321150-ev6acl7b 122 7 alignments alignment NNS cord-321150-ev6acl7b 122 8 each each DT cord-321150-ev6acl7b 122 9 contained contain VBD cord-321150-ev6acl7b 122 10 around around RB cord-321150-ev6acl7b 122 11 1,000 1,000 CD cord-321150-ev6acl7b 122 12 sequences sequence NNS cord-321150-ev6acl7b 122 13 . . . cord-321150-ev6acl7b 123 1 The the DT cord-321150-ev6acl7b 123 2 Ebola Ebola NNP cord-321150-ev6acl7b 123 3 virus virus NN cord-321150-ev6acl7b 123 4 data datum NNS cord-321150-ev6acl7b 123 5 showed show VBD cord-321150-ev6acl7b 123 6 no no DT cord-321150-ev6acl7b 123 7 evidence evidence NN cord-321150-ev6acl7b 123 8 of of IN cord-321150-ev6acl7b 123 9 recombination recombination NN cord-321150-ev6acl7b 123 10 . . . cord-321150-ev6acl7b 124 1 The the DT cord-321150-ev6acl7b 124 2 dengue dengue NN cord-321150-ev6acl7b 124 3 alignment alignment NN cord-321150-ev6acl7b 124 4 was be VBD cord-321150-ev6acl7b 124 5 the the DT cord-321150-ev6acl7b 124 6 most most RBS cord-321150-ev6acl7b 124 7 diverse diverse JJ cord-321150-ev6acl7b 124 8 of of IN cord-321150-ev6acl7b 124 9 all all PDT cord-321150-ev6acl7b 124 10 the the DT cord-321150-ev6acl7b 124 11 tested test VBN cord-321150-ev6acl7b 124 12 data data NN cord-321150-ev6acl7b 124 13 sets set NNS cord-321150-ev6acl7b 124 14 with with IN cord-321150-ev6acl7b 124 15 6,151 6,151 CD cord-321150-ev6acl7b 124 16 polymorphic polymorphic JJ cord-321150-ev6acl7b 124 17 sites site NNS cord-321150-ev6acl7b 124 18 ; ; : cord-321150-ev6acl7b 124 19 99.4 99.4 CD cord-321150-ev6acl7b 124 20 % % NN cord-321150-ev6acl7b 124 21 of of IN cord-321150-ev6acl7b 124 22 the the DT cord-321150-ev6acl7b 124 23 triplets triplet NNS cord-321150-ev6acl7b 124 24 in in IN cord-321150-ev6acl7b 124 25 this this DT cord-321150-ev6acl7b 124 26 data data NN cord-321150-ev6acl7b 124 27 set set VBN cord-321150-ev6acl7b 124 28 were be VBD cord-321150-ev6acl7b 124 29 able able JJ cord-321150-ev6acl7b 124 30 to to TO cord-321150-ev6acl7b 124 31 be be VB cord-321150-ev6acl7b 124 32 evaluated evaluate VBN cord-321150-ev6acl7b 124 33 with with IN cord-321150-ev6acl7b 124 34 exact exact JJ cord-321150-ev6acl7b 124 35 P p NN cord-321150-ev6acl7b 124 36 values value NNS cord-321150-ev6acl7b 124 37 . . . cord-321150-ev6acl7b 125 1 A a DT cord-321150-ev6acl7b 125 2 total total NN cord-321150-ev6acl7b 125 3 of of IN cord-321150-ev6acl7b 125 4 36 36 CD cord-321150-ev6acl7b 125 5 out out IN cord-321150-ev6acl7b 125 6 of of IN cord-321150-ev6acl7b 125 7 1,108 1,108 CD cord-321150-ev6acl7b 125 8 dengue dengue NN cord-321150-ev6acl7b 125 9 sequences sequence NNS cord-321150-ev6acl7b 125 10 were be VBD cord-321150-ev6acl7b 125 11 identified identify VBN cord-321150-ev6acl7b 125 12 as as IN cord-321150-ev6acl7b 125 13 recombinant recombinant JJ cord-321150-ev6acl7b 125 14 ( ( -LRB- cord-321150-ev6acl7b 125 15 see see VB cord-321150-ev6acl7b 125 16 Supplementary Supplementary NNP cord-321150-ev6acl7b 125 17 Material Material NNP cord-321150-ev6acl7b 125 18 online online RB cord-321150-ev6acl7b 125 19 ) ) -RRB- cord-321150-ev6acl7b 125 20 . . . cord-321150-ev6acl7b 126 1 Several several JJ cord-321150-ev6acl7b 126 2 previous previous JJ cord-321150-ev6acl7b 126 3 analyses analysis NNS cord-321150-ev6acl7b 126 4 of of IN cord-321150-ev6acl7b 126 5 dengue dengue NN cord-321150-ev6acl7b 126 6 virus virus NN cord-321150-ev6acl7b 126 7 have have VBP cord-321150-ev6acl7b 126 8 shown show VBN cord-321150-ev6acl7b 126 9 evidence evidence NN cord-321150-ev6acl7b 126 10 for for IN cord-321150-ev6acl7b 126 11 intraserotype intraserotype NN cord-321150-ev6acl7b 126 12 recombination recombination NN cord-321150-ev6acl7b 126 13 in in IN cord-321150-ev6acl7b 126 14 dengue dengue NN cord-321150-ev6acl7b 126 15 Worobey Worobey NNP cord-321150-ev6acl7b 126 16 et et NNP cord-321150-ev6acl7b 126 17 al al NNP cord-321150-ev6acl7b 126 18 . . . cord-321150-ev6acl7b 127 1 1999 1999 CD cord-321150-ev6acl7b 127 2 ; ; : cord-321150-ev6acl7b 127 3 Uzcategui Uzcategui NNP cord-321150-ev6acl7b 127 4 et et NNP cord-321150-ev6acl7b 127 5 al al NNP cord-321150-ev6acl7b 127 6 . . . cord-321150-ev6acl7b 128 1 2001 2001 CD cord-321150-ev6acl7b 128 2 ; ; : cord-321150-ev6acl7b 128 3 Aaskov Aaskov NNP cord-321150-ev6acl7b 128 4 et et NNP cord-321150-ev6acl7b 128 5 al al NNP cord-321150-ev6acl7b 128 6 . . . cord-321150-ev6acl7b 129 1 2007 2007 CD cord-321150-ev6acl7b 129 2 ; ; : cord-321150-ev6acl7b 129 3 Waman Waman NNP cord-321150-ev6acl7b 129 4 et et NNP cord-321150-ev6acl7b 129 5 al al NNP cord-321150-ev6acl7b 129 6 . . . cord-321150-ev6acl7b 130 1 2016 2016 CD cord-321150-ev6acl7b 131 1 Waman Waman NNP cord-321150-ev6acl7b 131 2 et et NNP cord-321150-ev6acl7b 131 3 al al NNP cord-321150-ev6acl7b 131 4 . . NNP cord-321150-ev6acl7b 131 5 , , , cord-321150-ev6acl7b 131 6 2017 2017 CD cord-321150-ev6acl7b 131 7 . . . cord-321150-ev6acl7b 132 1 The the DT cord-321150-ev6acl7b 132 2 results result NNS cord-321150-ev6acl7b 132 3 presented present VBN cord-321150-ev6acl7b 132 4 here here RB cord-321150-ev6acl7b 132 5 , , , cord-321150-ev6acl7b 132 6 as as RB cord-321150-ev6acl7b 132 7 well well RB cord-321150-ev6acl7b 132 8 as as IN cord-321150-ev6acl7b 132 9 those those DT cord-321150-ev6acl7b 132 10 of of IN cord-321150-ev6acl7b 132 11 Waman Waman NNP cord-321150-ev6acl7b 132 12 et et NNP cord-321150-ev6acl7b 132 13 al al NNP cord-321150-ev6acl7b 132 14 . . . cord-321150-ev6acl7b 133 1 ( ( -LRB- cord-321150-ev6acl7b 133 2 2017 2017 CD cord-321150-ev6acl7b 133 3 ) ) -RRB- cord-321150-ev6acl7b 133 4 , , , cord-321150-ev6acl7b 133 5 suggest suggest VBP cord-321150-ev6acl7b 133 6 that that IN cord-321150-ev6acl7b 133 7 recombination recombination NN cord-321150-ev6acl7b 133 8 in in IN cord-321150-ev6acl7b 133 9 dengue dengue NN cord-321150-ev6acl7b 133 10 is be VBZ cord-321150-ev6acl7b 133 11 infrequent infrequent JJ cord-321150-ev6acl7b 133 12 . . . cord-321150-ev6acl7b 134 1 In in IN cord-321150-ev6acl7b 134 2 general general JJ cord-321150-ev6acl7b 134 3 , , , cord-321150-ev6acl7b 134 4 when when WRB cord-321150-ev6acl7b 134 5 recombinants recombinant NNS cord-321150-ev6acl7b 134 6 are be VBP cord-321150-ev6acl7b 134 7 identified identify VBN cord-321150-ev6acl7b 134 8 by by IN cord-321150-ev6acl7b 134 9 a a DT cord-321150-ev6acl7b 134 10 mosaicism mosaicism NN cord-321150-ev6acl7b 134 11 statistic statistic NN cord-321150-ev6acl7b 134 12 like like IN cord-321150-ev6acl7b 134 13 the the DT cord-321150-ev6acl7b 134 14 one one NN cord-321150-ev6acl7b 134 15 used use VBN cord-321150-ev6acl7b 134 16 by by IN cord-321150-ev6acl7b 134 17 3SEQ 3SEQ NNP cord-321150-ev6acl7b 134 18 , , , cord-321150-ev6acl7b 134 19 a a DT cord-321150-ev6acl7b 134 20 phylogenetic phylogenetic JJ cord-321150-ev6acl7b 134 21 analysis analysis NN cord-321150-ev6acl7b 134 22 should should MD cord-321150-ev6acl7b 134 23 be be VB cord-321150-ev6acl7b 134 24 performed perform VBN cord-321150-ev6acl7b 134 25 to to TO cord-321150-ev6acl7b 134 26 ensure ensure VB cord-321150-ev6acl7b 134 27 that that IN cord-321150-ev6acl7b 134 28 the the DT cord-321150-ev6acl7b 134 29 recombination recombination NN cord-321150-ev6acl7b 134 30 signal signal NN cord-321150-ev6acl7b 134 31 is be VBZ cord-321150-ev6acl7b 134 32 preserved preserve VBN cord-321150-ev6acl7b 134 33 when when WRB cord-321150-ev6acl7b 134 34 the the DT cord-321150-ev6acl7b 134 35 entire entire JJ cord-321150-ev6acl7b 134 36 evolutionary evolutionary JJ cord-321150-ev6acl7b 134 37 history history NN cord-321150-ev6acl7b 134 38 of of IN cord-321150-ev6acl7b 134 39 the the DT cord-321150-ev6acl7b 134 40 sample sample NN cord-321150-ev6acl7b 134 41 is be VBZ cord-321150-ev6acl7b 134 42 taken take VBN cord-321150-ev6acl7b 134 43 into into IN cord-321150-ev6acl7b 134 44 account account NN cord-321150-ev6acl7b 134 45 . . . cord-321150-ev6acl7b 135 1 The the DT cord-321150-ev6acl7b 135 2 size size NN cord-321150-ev6acl7b 135 3 of of IN cord-321150-ev6acl7b 135 4 modern modern JJ cord-321150-ev6acl7b 135 5 data datum NNS cord-321150-ev6acl7b 135 6 sets set NNS cord-321150-ev6acl7b 135 7 presents present VBZ cord-321150-ev6acl7b 135 8 two two CD cord-321150-ev6acl7b 135 9 challenges challenge NNS cord-321150-ev6acl7b 135 10 here here RB cord-321150-ev6acl7b 135 11 . . . cord-321150-ev6acl7b 136 1 First first RB cord-321150-ev6acl7b 136 2 , , , cord-321150-ev6acl7b 136 3 as as IN cord-321150-ev6acl7b 136 4 the the DT cord-321150-ev6acl7b 136 5 number number NN cord-321150-ev6acl7b 136 6 of of IN cord-321150-ev6acl7b 136 7 available available JJ cord-321150-ev6acl7b 136 8 sequences sequence NNS cord-321150-ev6acl7b 136 9 increases increase VBZ cord-321150-ev6acl7b 136 10 , , , cord-321150-ev6acl7b 136 11 the the DT cord-321150-ev6acl7b 136 12 choice choice NN cord-321150-ev6acl7b 136 13 for for IN cord-321150-ev6acl7b 136 14 phylogenetic phylogenetic JJ cord-321150-ev6acl7b 136 15 inference inference NN cord-321150-ev6acl7b 136 16 tools tool NNS cord-321150-ev6acl7b 136 17 drifts drift VBZ cord-321150-ev6acl7b 136 18 to to IN cord-321150-ev6acl7b 136 19 more more JJR cord-321150-ev6acl7b 136 20 approximate approximate JJ cord-321150-ev6acl7b 136 21 methods method NNS cord-321150-ev6acl7b 136 22 , , , cord-321150-ev6acl7b 136 23 as as IN cord-321150-ev6acl7b 136 24 thorough thorough JJ cord-321150-ev6acl7b 136 25 explorations exploration NNS cord-321150-ev6acl7b 136 26 of of IN cord-321150-ev6acl7b 136 27 tree tree NN cord-321150-ev6acl7b 136 28 space space NN cord-321150-ev6acl7b 136 29 become become VBP cord-321150-ev6acl7b 136 30 computationally computationally RB cord-321150-ev6acl7b 136 31 expensive expensive JJ cord-321150-ev6acl7b 136 32 for for IN cord-321150-ev6acl7b 136 33 large large JJ cord-321150-ev6acl7b 136 34 numbers number NNS cord-321150-ev6acl7b 136 35 of of IN cord-321150-ev6acl7b 136 36 sequences sequence NNS cord-321150-ev6acl7b 136 37 . . . cord-321150-ev6acl7b 137 1 This this DT cord-321150-ev6acl7b 137 2 reduces reduce VBZ cord-321150-ev6acl7b 137 3 our -PRON- PRP$ cord-321150-ev6acl7b 137 4 confidence confidence NN cord-321150-ev6acl7b 137 5 in in IN cord-321150-ev6acl7b 137 6 phylogenetic phylogenetic JJ cord-321150-ev6acl7b 137 7 incongruence incongruence NN cord-321150-ev6acl7b 137 8 signals signal NNS cord-321150-ev6acl7b 137 9 that that IN cord-321150-ev6acl7b 137 10 we -PRON- PRP cord-321150-ev6acl7b 137 11 observe observe VBP cord-321150-ev6acl7b 137 12 in in IN cord-321150-ev6acl7b 137 13 these these DT cord-321150-ev6acl7b 137 14 data datum NNS cord-321150-ev6acl7b 137 15 . . . cord-321150-ev6acl7b 138 1 Second second RB cord-321150-ev6acl7b 138 2 , , , cord-321150-ev6acl7b 138 3 genome genome NN cord-321150-ev6acl7b 138 4 - - HYPH cord-321150-ev6acl7b 138 5 level level NN cord-321150-ev6acl7b 138 6 analyses analysis NNS cord-321150-ev6acl7b 138 7 in in IN cord-321150-ev6acl7b 138 8 highly highly RB cord-321150-ev6acl7b 138 9 recombining recombine VBG cord-321150-ev6acl7b 138 10 organisms organism NNS cord-321150-ev6acl7b 138 11 are be VBP cord-321150-ev6acl7b 138 12 likely likely JJ cord-321150-ev6acl7b 138 13 to to TO cord-321150-ev6acl7b 138 14 result result VB cord-321150-ev6acl7b 138 15 in in IN cord-321150-ev6acl7b 138 16 a a DT cord-321150-ev6acl7b 138 17 subdivision subdivision NN cord-321150-ev6acl7b 138 18 of of IN cord-321150-ev6acl7b 138 19 the the DT cord-321150-ev6acl7b 138 20 genome genome NN cord-321150-ev6acl7b 138 21 into into IN cord-321150-ev6acl7b 138 22 many many JJ cord-321150-ev6acl7b 138 23 nonrecombinant nonrecombinant NN cord-321150-ev6acl7b 138 24 blocks block NNS cord-321150-ev6acl7b 138 25 . . . cord-321150-ev6acl7b 139 1 Inferring infer VBG cord-321150-ev6acl7b 139 2 phylogenies phylogeny NNS cord-321150-ev6acl7b 139 3 for for IN cord-321150-ev6acl7b 139 4 all all DT cord-321150-ev6acl7b 139 5 blocks block NNS cord-321150-ev6acl7b 139 6 individually individually RB cord-321150-ev6acl7b 139 7 will will MD cord-321150-ev6acl7b 139 8 be be VB cord-321150-ev6acl7b 139 9 computationally computationally RB cord-321150-ev6acl7b 139 10 expensive expensive JJ cord-321150-ev6acl7b 139 11 , , , cord-321150-ev6acl7b 139 12 as as IN cord-321150-ev6acl7b 139 13 will will MD cord-321150-ev6acl7b 139 14 the the DT cord-321150-ev6acl7b 139 15 subsequent subsequent JJ cord-321150-ev6acl7b 139 16 analysis analysis NN cord-321150-ev6acl7b 139 17 of of IN cord-321150-ev6acl7b 139 18 identifying identify VBG cord-321150-ev6acl7b 139 19 specific specific JJ cord-321150-ev6acl7b 139 20 phylogenetic phylogenetic JJ cord-321150-ev6acl7b 139 21 incongruences incongruence NNS cord-321150-ev6acl7b 139 22 among among IN cord-321150-ev6acl7b 139 23 the the DT cord-321150-ev6acl7b 139 24 trees tree NNS cord-321150-ev6acl7b 139 25 . . . cord-321150-ev6acl7b 140 1 The the DT cord-321150-ev6acl7b 140 2 next next JJ cord-321150-ev6acl7b 140 3 generation generation NN cord-321150-ev6acl7b 140 4 of of IN cord-321150-ev6acl7b 140 5 recombination recombination NN cord-321150-ev6acl7b 140 6 detection detection NN cord-321150-ev6acl7b 140 7 methods method NNS cord-321150-ev6acl7b 140 8 should should MD cord-321150-ev6acl7b 140 9 focus focus VB cord-321150-ev6acl7b 140 10 on on IN cord-321150-ev6acl7b 140 11 these these DT cord-321150-ev6acl7b 140 12 computational computational JJ cord-321150-ev6acl7b 140 13 challenges challenge NNS cord-321150-ev6acl7b 140 14 . . . cord-321150-ev6acl7b 141 1 Supplementary supplementary JJ cord-321150-ev6acl7b 141 2 data datum NNS cord-321150-ev6acl7b 141 3 are be VBP cord-321150-ev6acl7b 141 4 available available JJ cord-321150-ev6acl7b 141 5 at at IN cord-321150-ev6acl7b 141 6 Molecular Molecular NNP cord-321150-ev6acl7b 141 7 Biology Biology NNP cord-321150-ev6acl7b 141 8 and and CC cord-321150-ev6acl7b 141 9 Evolution Evolution NNP cord-321150-ev6acl7b 141 10 online online RB cord-321150-ev6acl7b 141 11 . . . cord-321150-ev6acl7b 141 12 _SP cord-321150-ev6acl7b 142 1 Multiple multiple JJ cord-321150-ev6acl7b 142 2 recombinant recombinant JJ cord-321150-ev6acl7b 142 3 dengue dengue NN cord-321150-ev6acl7b 142 4 type type NN cord-321150-ev6acl7b 142 5 1 1 CD cord-321150-ev6acl7b 142 6 viruses virus NNS cord-321150-ev6acl7b 142 7 in in IN cord-321150-ev6acl7b 142 8 an an DT cord-321150-ev6acl7b 142 9 isolate isolate NN cord-321150-ev6acl7b 142 10 from from IN cord-321150-ev6acl7b 142 11 a a DT cord-321150-ev6acl7b 142 12 dengue dengue NN cord-321150-ev6acl7b 142 13 patient patient NN cord-321150-ev6acl7b 142 14 Guidelines guideline NNS cord-321150-ev6acl7b 142 15 for for IN cord-321150-ev6acl7b 142 16 identifying identify VBG cord-321150-ev6acl7b 142 17 homologous homologous JJ cord-321150-ev6acl7b 142 18 recombination recombination NN cord-321150-ev6acl7b 142 19 events event NNS cord-321150-ev6acl7b 142 20 in in IN cord-321150-ev6acl7b 142 21 influenza influenza NN cord-321150-ev6acl7b 142 22 A a DT cord-321150-ev6acl7b 142 23 virus virus NN cord-321150-ev6acl7b 143 1 An an DT cord-321150-ev6acl7b 143 2 exact exact JJ cord-321150-ev6acl7b 143 3 nonparametric nonparametric JJ cord-321150-ev6acl7b 143 4 method method NN cord-321150-ev6acl7b 143 5 for for IN cord-321150-ev6acl7b 143 6 inferring infer VBG cord-321150-ev6acl7b 143 7 mosaic mosaic JJ cord-321150-ev6acl7b 143 8 structure structure NN cord-321150-ev6acl7b 143 9 in in IN cord-321150-ev6acl7b 144 1 sequence sequence NN cord-321150-ev6acl7b 144 2 triplets triplet NNS cord-321150-ev6acl7b 145 1 Virus virus NN cord-321150-ev6acl7b 145 2 variation variation NN cord-321150-ev6acl7b 145 3 resource resource NN cord-321150-ev6acl7b 145 4 -recent -recent NN cord-321150-ev6acl7b 145 5 updates update NNS cord-321150-ev6acl7b 145 6 and and CC cord-321150-ev6acl7b 145 7 future future JJ cord-321150-ev6acl7b 145 8 directions direction NNS cord-321150-ev6acl7b 145 9 MERS MERS NNP cord-321150-ev6acl7b 145 10 - - HYPH cord-321150-ev6acl7b 145 11 CoV cov NN cord-321150-ev6acl7b 145 12 recombination recombination NN cord-321150-ev6acl7b 145 13 : : : cord-321150-ev6acl7b 145 14 implications implication NNS cord-321150-ev6acl7b 145 15 about about IN cord-321150-ev6acl7b 145 16 the the DT cord-321150-ev6acl7b 145 17 reservoir reservoir NN cord-321150-ev6acl7b 145 18 and and CC cord-321150-ev6acl7b 145 19 potential potential NN cord-321150-ev6acl7b 145 20 for for IN cord-321150-ev6acl7b 145 21 adaptation adaptation NN cord-321150-ev6acl7b 145 22 MUSCLE muscle NN cord-321150-ev6acl7b 145 23 : : : cord-321150-ev6acl7b 146 1 multiple multiple JJ cord-321150-ev6acl7b 146 2 sequence sequence NN cord-321150-ev6acl7b 146 3 alignment alignment NN cord-321150-ev6acl7b 146 4 with with IN cord-321150-ev6acl7b 146 5 high high JJ cord-321150-ev6acl7b 146 6 accuracy accuracy NN cord-321150-ev6acl7b 146 7 and and CC cord-321150-ev6acl7b 146 8 high high JJ cord-321150-ev6acl7b 146 9 throughput throughput NN cord-321150-ev6acl7b 146 10 Molecular molecular JJ cord-321150-ev6acl7b 146 11 evolution evolution NN cord-321150-ev6acl7b 146 12 of of IN cord-321150-ev6acl7b 146 13 Zika Zika NNP cord-321150-ev6acl7b 146 14 virus virus NN cord-321150-ev6acl7b 146 15 during during IN cord-321150-ev6acl7b 146 16 its -PRON- PRP$ cord-321150-ev6acl7b 146 17 emergence emergence NN cord-321150-ev6acl7b 146 18 in in IN cord-321150-ev6acl7b 146 19 the the DT cord-321150-ev6acl7b 146 20 20th 20th JJ cord-321150-ev6acl7b 146 21 century century NN cord-321150-ev6acl7b 146 22 Large large JJ cord-321150-ev6acl7b 146 23 - - HYPH cord-321150-ev6acl7b 146 24 scale scale NN cord-321150-ev6acl7b 146 25 sequencing sequencing NN cord-321150-ev6acl7b 146 26 of of IN cord-321150-ev6acl7b 146 27 human human JJ cord-321150-ev6acl7b 146 28 influenza influenza NN cord-321150-ev6acl7b 146 29 reveals reveal VBZ cord-321150-ev6acl7b 146 30 the the DT cord-321150-ev6acl7b 146 31 dynamic dynamic JJ cord-321150-ev6acl7b 146 32 nature nature NN cord-321150-ev6acl7b 146 33 of of IN cord-321150-ev6acl7b 146 34 viral viral JJ cord-321150-ev6acl7b 146 35 genome genome NN cord-321150-ev6acl7b 146 36 evolution evolution NN cord-321150-ev6acl7b 146 37 Dengue dengue NN cord-321150-ev6acl7b 146 38 and and CC cord-321150-ev6acl7b 146 39 dengue dengue NN cord-321150-ev6acl7b 146 40 hemorrhagic hemorrhagic JJ cord-321150-ev6acl7b 146 41 fever fever NN cord-321150-ev6acl7b 147 1 No no DT cord-321150-ev6acl7b 147 2 observed observed JJ cord-321150-ev6acl7b 147 3 effect effect NN cord-321150-ev6acl7b 147 4 of of IN cord-321150-ev6acl7b 147 5 homologous homologous JJ cord-321150-ev6acl7b 147 6 recombination recombination NN cord-321150-ev6acl7b 147 7 on on IN cord-321150-ev6acl7b 147 8 influenza influenza NN cord-321150-ev6acl7b 147 9 C C NNP cord-321150-ev6acl7b 147 10 virus virus NN cord-321150-ev6acl7b 147 11 evolution evolution NN cord-321150-ev6acl7b 147 12 Large large JJ cord-321150-ev6acl7b 147 13 deviations deviation NNS cord-321150-ev6acl7b 147 14 for for IN cord-321150-ev6acl7b 147 15 the the DT cord-321150-ev6acl7b 147 16 maxima maxima NN cord-321150-ev6acl7b 147 17 of of IN cord-321150-ev6acl7b 147 18 some some DT cord-321150-ev6acl7b 147 19 random random JJ cord-321150-ev6acl7b 147 20 fields field NNS cord-321150-ev6acl7b 148 1 Phylogenetic phylogenetic JJ cord-321150-ev6acl7b 148 2 evidence evidence NN cord-321150-ev6acl7b 148 3 for for IN cord-321150-ev6acl7b 148 4 recombination recombination NN cord-321150-ev6acl7b 148 5 in in IN cord-321150-ev6acl7b 148 6 dengue dengue NN cord-321150-ev6acl7b 148 7 virus virus NN cord-321150-ev6acl7b 148 8 Analysing analyse VBG cord-321150-ev6acl7b 148 9 recombination recombination NN cord-321150-ev6acl7b 148 10 in in IN cord-321150-ev6acl7b 148 11 nucleotide nucleotide JJ cord-321150-ev6acl7b 148 12 sequences sequence NNS cord-321150-ev6acl7b 148 13 Evaluation Evaluation NNP cord-321150-ev6acl7b 148 14 of of IN cord-321150-ev6acl7b 148 15 methods method NNS cord-321150-ev6acl7b 148 16 for for IN cord-321150-ev6acl7b 148 17 detecting detect VBG cord-321150-ev6acl7b 148 18 recombination recombination NN cord-321150-ev6acl7b 148 19 from from IN cord-321150-ev6acl7b 148 20 DNA dna NN cord-321150-ev6acl7b 148 21 sequences sequence NNS cord-321150-ev6acl7b 148 22 : : : cord-321150-ev6acl7b 148 23 computer computer NN cord-321150-ev6acl7b 148 24 simulations simulation NNS cord-321150-ev6acl7b 149 1 The the DT cord-321150-ev6acl7b 149 2 effect effect NN cord-321150-ev6acl7b 149 3 of of IN cord-321150-ev6acl7b 149 4 recombination recombination NN cord-321150-ev6acl7b 149 5 on on IN cord-321150-ev6acl7b 149 6 the the DT cord-321150-ev6acl7b 149 7 accuracy accuracy NN cord-321150-ev6acl7b 149 8 of of IN cord-321150-ev6acl7b 149 9 phylogeny phylogeny NN cord-321150-ev6acl7b 149 10 estimation estimation NN cord-321150-ev6acl7b 149 11 Recombination Recombination NNP cord-321150-ev6acl7b 149 12 in in IN cord-321150-ev6acl7b 149 13 evolutionary evolutionary JJ cord-321150-ev6acl7b 149 14 genomics genomic NNS cord-321150-ev6acl7b 149 15 Consequences consequence NNS cord-321150-ev6acl7b 149 16 of of IN cord-321150-ev6acl7b 149 17 recombination recombination NN cord-321150-ev6acl7b 149 18 on on IN cord-321150-ev6acl7b 149 19 traditional traditional JJ cord-321150-ev6acl7b 149 20 phylogenetic phylogenetic JJ cord-321150-ev6acl7b 149 21 analysis analysis NN cord-321150-ev6acl7b 150 1 Molecular molecular JJ cord-321150-ev6acl7b 150 2 epidemiology epidemiology NN cord-321150-ev6acl7b 150 3 of of IN cord-321150-ev6acl7b 150 4 dengue dengue NN cord-321150-ev6acl7b 150 5 type type NN cord-321150-ev6acl7b 150 6 2 2 CD cord-321150-ev6acl7b 150 7 virus virus NN cord-321150-ev6acl7b 150 8 in in IN cord-321150-ev6acl7b 150 9 Venezuela Venezuela NNP cord-321150-ev6acl7b 150 10 : : : cord-321150-ev6acl7b 150 11 evidence evidence NN cord-321150-ev6acl7b 150 12 for for IN cord-321150-ev6acl7b 150 13 in in IN cord-321150-ev6acl7b 150 14 situ situ NN cord-321150-ev6acl7b 150 15 virus virus NN cord-321150-ev6acl7b 150 16 evolution evolution NN cord-321150-ev6acl7b 150 17 and and CC cord-321150-ev6acl7b 150 18 recombination recombination NN cord-321150-ev6acl7b 150 19 Genetic genetic JJ cord-321150-ev6acl7b 150 20 diversity diversity NN cord-321150-ev6acl7b 150 21 and and CC cord-321150-ev6acl7b 150 22 evolution evolution NN cord-321150-ev6acl7b 150 23 of of IN cord-321150-ev6acl7b 150 24 dengue dengue NN cord-321150-ev6acl7b 150 25 virus virus NN cord-321150-ev6acl7b 150 26 serotype serotype NN cord-321150-ev6acl7b 150 27 3 3 CD cord-321150-ev6acl7b 150 28 : : : cord-321150-ev6acl7b 150 29 a a DT cord-321150-ev6acl7b 150 30 comparative comparative JJ cord-321150-ev6acl7b 150 31 genomics genomic NNS cord-321150-ev6acl7b 150 32 study study NN cord-321150-ev6acl7b 150 33 Population population NN cord-321150-ev6acl7b 150 34 genomics genomic NNS cord-321150-ev6acl7b 150 35 of of IN cord-321150-ev6acl7b 150 36 dengue dengue NN cord-321150-ev6acl7b 150 37 virus virus NN cord-321150-ev6acl7b 150 38 serotype serotype NN cord-321150-ev6acl7b 150 39 4 4 CD cord-321150-ev6acl7b 150 40 : : : cord-321150-ev6acl7b 150 41 insights insight NNS cord-321150-ev6acl7b 150 42 into into IN cord-321150-ev6acl7b 150 43 genetic genetic JJ cord-321150-ev6acl7b 150 44 structure structure NN cord-321150-ev6acl7b 150 45 and and CC cord-321150-ev6acl7b 150 46 evolution evolution NN cord-321150-ev6acl7b 151 1 The the DT cord-321150-ev6acl7b 151 2 effects effect NNS cord-321150-ev6acl7b 151 3 of of IN cord-321150-ev6acl7b 151 4 tertiary tertiary JJ cord-321150-ev6acl7b 151 5 and and CC cord-321150-ev6acl7b 151 6 quaternary quaternary JJ cord-321150-ev6acl7b 151 7 infections infection NNS cord-321150-ev6acl7b 151 8 on on IN cord-321150-ev6acl7b 151 9 the the DT cord-321150-ev6acl7b 151 10 epidemiology epidemiology NN cord-321150-ev6acl7b 151 11 of of IN cord-321150-ev6acl7b 151 12 dengue dengue NN cord-321150-ev6acl7b 151 13 Widespread widespread JJ cord-321150-ev6acl7b 151 14 intra intra JJ cord-321150-ev6acl7b 151 15 - - JJ cord-321150-ev6acl7b 151 16 serotype serotype JJ cord-321150-ev6acl7b 151 17 recombination recombination NN cord-321150-ev6acl7b 151 18 in in IN cord-321150-ev6acl7b 151 19 natural natural JJ cord-321150-ev6acl7b 151 20 populations population NNS cord-321150-ev6acl7b 151 21 of of IN cord-321150-ev6acl7b 151 22 dengue dengue NN cord-321150-ev6acl7b 151 23 virus virus NN cord-321150-ev6acl7b 151 24 Comparative comparative JJ cord-321150-ev6acl7b 151 25 genomic genomic JJ cord-321150-ev6acl7b 151 26 analysis analysis NN cord-321150-ev6acl7b 151 27 of of IN cord-321150-ev6acl7b 151 28 pre pre JJ cord-321150-ev6acl7b 151 29 - - JJ cord-321150-ev6acl7b 151 30 epidemic epidemic JJ cord-321150-ev6acl7b 151 31 and and CC cord-321150-ev6acl7b 151 32 epidemic epidemic NN cord-321150-ev6acl7b 151 33 Zika Zika NNP cord-321150-ev6acl7b 151 34 virus virus NN cord-321150-ev6acl7b 151 35 strains strain VBZ cord-321150-ev6acl7b 151 36 for for IN cord-321150-ev6acl7b 151 37 virological virological JJ cord-321150-ev6acl7b 151 38 factors factor NNS cord-321150-ev6acl7b 151 39 potentially potentially RB cord-321150-ev6acl7b 151 40 associated associate VBN cord-321150-ev6acl7b 151 41 with with IN cord-321150-ev6acl7b 151 42 the the DT cord-321150-ev6acl7b 151 43 rapidly rapidly RB cord-321150-ev6acl7b 151 44 expanding expand VBG cord-321150-ev6acl7b 151 45 epidemic epidemic NN