id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000257-ampip7od	Bagowski, Christoph P	The Nature of Protein Domain Evolution: Shaping the Interaction Network	2010-08-17		.txt	text/plain	4678	249	43	With the present and still increasing wealth of sequences and annotation data brought about by genomics, new evolutionary relationships are constantly being revealed, unknown structures modeled and phylogenies inferred. In this review, we aim to describe the basic concepts of protein domain evolution and illustrate recent developments in molecular evolution that have provided valuable new insights in the field of comparative genomics and protein interaction networks. This likely stems from the fact that they are required to participate in many different interactions, which makes selection pressures more stringent and the appearance of the branches on phylogenetic trees relatively short and more difficult to assess when co-evolutionary data in terms of other domains in the same gene family or expression patterns is limited [42, 63] . This approach thus primarily focuses on the similarity and differences of the orthologous genes within network, and is therefore ideally suited for the study of protein domain evolution and has already revealed that species-specific parts Fig.	./cache/cord-000257-ampip7od.txt	./txt/cord-000257-ampip7od.txt