id	sid	tid	token	lemma	pos
cord-017337-vq3edhxn	1	1	key	key	NN
cord-017337-vq3edhxn	1	2	:	:	:
cord-017337-vq3edhxn	2	1	cord-017337-vq3edhxn	cord-017337-vq3edhxn	:
cord-017337-vq3edhxn	2	2	authors	author	NNS
cord-017337-vq3edhxn	2	3	:	:	:
cord-017337-vq3edhxn	2	4	Vincent	Vincent	NNP
cord-017337-vq3edhxn	2	5	,	,	,
cord-017337-vq3edhxn	2	6	Jean	Jean	NNP
cord-017337-vq3edhxn	2	7	-	-	HYPH
cord-017337-vq3edhxn	2	8	Louis	Louis	NNP
cord-017337-vq3edhxn	2	9	title	title	NN
cord-017337-vq3edhxn	2	10	:	:	:
cord-017337-vq3edhxn	2	11	PIRO	PIRO	NNP
cord-017337-vq3edhxn	2	12	:	:	:
cord-017337-vq3edhxn	3	1	The	the	DT
cord-017337-vq3edhxn	3	2	Key	Key	NNP
cord-017337-vq3edhxn	3	3	to	to	IN
cord-017337-vq3edhxn	3	4	Success	Success	NNP
cord-017337-vq3edhxn	3	5	?	?	.
cord-017337-vq3edhxn	4	1	date	date	NN
cord-017337-vq3edhxn	4	2	:	:	:
cord-017337-vq3edhxn	5	1	2009	2009	CD
cord-017337-vq3edhxn	5	2	journal	journal	NN
cord-017337-vq3edhxn	5	3	:	:	:
cord-017337-vq3edhxn	5	4	Management	Management	NNP
cord-017337-vq3edhxn	5	5	of	of	IN
cord-017337-vq3edhxn	5	6	Sepsis	Sepsis	NNP
cord-017337-vq3edhxn	5	7	:	:	:
cord-017337-vq3edhxn	6	1	The	the	DT
cord-017337-vq3edhxn	6	2	PIRO	PIRO	NNP
cord-017337-vq3edhxn	6	3	Approach	Approach	NNP
cord-017337-vq3edhxn	6	4	DOI	doi	NN
cord-017337-vq3edhxn	6	5	:	:	:
cord-017337-vq3edhxn	7	1	10.1007/978	10.1007/978	LS
cord-017337-vq3edhxn	7	2	-	-	SYM
cord-017337-vq3edhxn	7	3	3	3	CD
cord-017337-vq3edhxn	7	4	-	-	HYPH
cord-017337-vq3edhxn	7	5	642	642	CD
cord-017337-vq3edhxn	7	6	-	-	HYPH
cord-017337-vq3edhxn	7	7	00479	00479	CD
cord-017337-vq3edhxn	7	8	-	-	HYPH
cord-017337-vq3edhxn	7	9	7_1	7_1	CD
cord-017337-vq3edhxn	7	10	sha	sha	NNP
cord-017337-vq3edhxn	7	11	:	:	:
cord-017337-vq3edhxn	8	1	65475038f09a4ecfb8b68cad3426d9f0e2605f16	65475038f09a4ecfb8b68cad3426d9f0e2605f16	CD
cord-017337-vq3edhxn	8	2	doc_id	doc_id	CD
cord-017337-vq3edhxn	8	3	:	:	:
cord-017337-vq3edhxn	9	1	17337	17337	CD
cord-017337-vq3edhxn	9	2	cord_uid	cord_uid	NNS
cord-017337-vq3edhxn	9	3	:	:	:
cord-017337-vq3edhxn	9	4	vq3edhxn	vq3edhxn	.
cord-017337-vq3edhxn	10	1	Sepsis	sepsis	NN
cord-017337-vq3edhxn	10	2	continues	continue	VBZ
cord-017337-vq3edhxn	10	3	to	to	TO
cord-017337-vq3edhxn	10	4	represent	represent	VB
cord-017337-vq3edhxn	10	5	a	a	DT
cord-017337-vq3edhxn	10	6	major	major	JJ
cord-017337-vq3edhxn	10	7	problem	problem	NN
cord-017337-vq3edhxn	10	8	in	in	IN
cord-017337-vq3edhxn	10	9	intensive	intensive	JJ
cord-017337-vq3edhxn	10	10	care	care	NN
cord-017337-vq3edhxn	10	11	units	unit	NNS
cord-017337-vq3edhxn	10	12	worldwide	worldwide	RB
cord-017337-vq3edhxn	10	13	.	.	.
cord-017337-vq3edhxn	11	1	Diagnosis	diagnosis	NN
cord-017337-vq3edhxn	11	2	and	and	CC
cord-017337-vq3edhxn	11	3	management	management	NN
cord-017337-vq3edhxn	11	4	are	be	VBP
cord-017337-vq3edhxn	11	5	often	often	RB
cord-017337-vq3edhxn	11	6	complex	complex	JJ
cord-017337-vq3edhxn	11	7	due	due	JJ
cord-017337-vq3edhxn	11	8	in	in	IN
cord-017337-vq3edhxn	11	9	part	part	NN
cord-017337-vq3edhxn	11	10	to	to	IN
cord-017337-vq3edhxn	11	11	the	the	DT
cord-017337-vq3edhxn	11	12	remarkably	remarkably	RB
cord-017337-vq3edhxn	11	13	diverse	diverse	JJ
cord-017337-vq3edhxn	11	14	nature	nature	NN
cord-017337-vq3edhxn	11	15	of	of	IN
cord-017337-vq3edhxn	11	16	the	the	DT
cord-017337-vq3edhxn	11	17	septic	septic	JJ
cord-017337-vq3edhxn	11	18	patient	patient	NN
cord-017337-vq3edhxn	11	19	.	.	.
cord-017337-vq3edhxn	12	1	Indeed	indeed	RB
cord-017337-vq3edhxn	12	2	,	,	,
cord-017337-vq3edhxn	12	3	sepsis	sepsis	NN
cord-017337-vq3edhxn	12	4	can	can	MD
cord-017337-vq3edhxn	12	5	range	range	VB
cord-017337-vq3edhxn	12	6	in	in	IN
cord-017337-vq3edhxn	12	7	severity	severity	NN
cord-017337-vq3edhxn	12	8	from	from	IN
cord-017337-vq3edhxn	12	9	mild	mild	JJ
cord-017337-vq3edhxn	12	10	systemic	systemic	JJ
cord-017337-vq3edhxn	12	11	inflammation	inflammation	NN
cord-017337-vq3edhxn	12	12	of	of	IN
cord-017337-vq3edhxn	12	13	little	little	JJ
cord-017337-vq3edhxn	12	14	clinical	clinical	JJ
cord-017337-vq3edhxn	12	15	importance	importance	NN
cord-017337-vq3edhxn	12	16	through	through	IN
cord-017337-vq3edhxn	12	17	to	to	IN
cord-017337-vq3edhxn	12	18	a	a	DT
cord-017337-vq3edhxn	12	19	widespread	widespread	JJ
cord-017337-vq3edhxn	12	20	severe	severe	JJ
cord-017337-vq3edhxn	12	21	inflammatory	inflammatory	JJ
cord-017337-vq3edhxn	12	22	response	response	NN
cord-017337-vq3edhxn	12	23	with	with	IN
cord-017337-vq3edhxn	12	24	multiple	multiple	JJ
cord-017337-vq3edhxn	12	25	organ	organ	NN
cord-017337-vq3edhxn	12	26	failure	failure	NN
cord-017337-vq3edhxn	12	27	and	and	CC
cord-017337-vq3edhxn	12	28	a	a	DT
cord-017337-vq3edhxn	12	29	mortality	mortality	NN
cord-017337-vq3edhxn	12	30	rate	rate	NN
cord-017337-vq3edhxn	12	31	in	in	IN
cord-017337-vq3edhxn	12	32	excess	excess	NN
cord-017337-vq3edhxn	12	33	of	of	IN
cord-017337-vq3edhxn	12	34	50	50	CD
cord-017337-vq3edhxn	12	35	%	%	NN
cord-017337-vq3edhxn	12	36	.	.	.
cord-017337-vq3edhxn	13	1	Sepsis	sepsis	NN
cord-017337-vq3edhxn	13	2	can	can	MD
cord-017337-vq3edhxn	13	3	affect	affect	VB
cord-017337-vq3edhxn	13	4	individuals	individual	NNS
cord-017337-vq3edhxn	13	5	of	of	IN
cord-017337-vq3edhxn	13	6	any	any	DT
cord-017337-vq3edhxn	13	7	age	age	NN
cord-017337-vq3edhxn	13	8	group	group	NN
cord-017337-vq3edhxn	13	9	,	,	,
cord-017337-vq3edhxn	13	10	with	with	IN
cord-017337-vq3edhxn	13	11	no	no	DT
cord-017337-vq3edhxn	13	12	or	or	CC
cord-017337-vq3edhxn	13	13	multiple	multiple	JJ
cord-017337-vq3edhxn	13	14	co	co	NNS
cord-017337-vq3edhxn	13	15	-	-	NNS
cord-017337-vq3edhxn	13	16	morbidities	morbidity	NNS
cord-017337-vq3edhxn	13	17	,	,	,
cord-017337-vq3edhxn	13	18	and	and	CC
cord-017337-vq3edhxn	13	19	with	with	IN
cord-017337-vq3edhxn	13	20	many	many	JJ
cord-017337-vq3edhxn	13	21	different	different	JJ
cord-017337-vq3edhxn	13	22	ongoing	ongoing	JJ
cord-017337-vq3edhxn	13	23	diagnoses	diagnosis	NNS
cord-017337-vq3edhxn	13	24	.	.	.
cord-017337-vq3edhxn	14	1	It	-PRON-	PRP
cord-017337-vq3edhxn	14	2	can	can	MD
cord-017337-vq3edhxn	14	3	occur	occur	VB
cord-017337-vq3edhxn	14	4	as	as	IN
cord-017337-vq3edhxn	14	5	the	the	DT
cord-017337-vq3edhxn	14	6	result	result	NN
cord-017337-vq3edhxn	14	7	of	of	IN
cord-017337-vq3edhxn	14	8	infection	infection	NN
cord-017337-vq3edhxn	14	9	by	by	IN
cord-017337-vq3edhxn	14	10	one	one	CD
cord-017337-vq3edhxn	14	11	or	or	CC
cord-017337-vq3edhxn	14	12	more	more	JJR
cord-017337-vq3edhxn	14	13	of	of	IN
cord-017337-vq3edhxn	14	14	a	a	DT
cord-017337-vq3edhxn	14	15	multitude	multitude	NN
cord-017337-vq3edhxn	14	16	of	of	IN
cord-017337-vq3edhxn	14	17	microbial	microbial	JJ
cord-017337-vq3edhxn	14	18	pathogens	pathogen	NNS
cord-017337-vq3edhxn	14	19	impacting	impact	VBG
cord-017337-vq3edhxn	14	20	on	on	IN
cord-017337-vq3edhxn	14	21	any	any	DT
cord-017337-vq3edhxn	14	22	of	of	IN
cord-017337-vq3edhxn	14	23	numerous	numerous	JJ
cord-017337-vq3edhxn	14	24	different	different	JJ
cord-017337-vq3edhxn	14	25	sites	site	NNS
cord-017337-vq3edhxn	14	26	within	within	IN
cord-017337-vq3edhxn	14	27	the	the	DT
cord-017337-vq3edhxn	14	28	body	body	NN
cord-017337-vq3edhxn	14	29	.	.	.
cord-017337-vq3edhxn	15	1	Given	give	VBN
cord-017337-vq3edhxn	15	2	the	the	DT
cord-017337-vq3edhxn	15	3	huge	huge	JJ
cord-017337-vq3edhxn	15	4	complexity	complexity	NN
cord-017337-vq3edhxn	15	5	of	of	IN
cord-017337-vq3edhxn	15	6	sepsis	sepsis	NN
cord-017337-vq3edhxn	15	7	and	and	CC
cord-017337-vq3edhxn	15	8	the	the	DT
cord-017337-vq3edhxn	15	9	diverse	diverse	JJ
cord-017337-vq3edhxn	15	10	populations	population	NNS
cord-017337-vq3edhxn	15	11	of	of	IN
cord-017337-vq3edhxn	15	12	patients	patient	NNS
cord-017337-vq3edhxn	15	13	it	-PRON-	PRP
cord-017337-vq3edhxn	15	14	affects	affect	VBZ
cord-017337-vq3edhxn	15	15	,	,	,
cord-017337-vq3edhxn	15	16	simple	simple	JJ
cord-017337-vq3edhxn	15	17	definitions	definition	NNS
cord-017337-vq3edhxn	15	18	are	be	VBP
cord-017337-vq3edhxn	15	19	of	of	IN
cord-017337-vq3edhxn	15	20	relatively	relatively	RB
cord-017337-vq3edhxn	15	21	little	little	JJ
cord-017337-vq3edhxn	15	22	use	use	NN
cord-017337-vq3edhxn	15	23	and	and	CC
cord-017337-vq3edhxn	15	24	a	a	DT
cord-017337-vq3edhxn	15	25	more	more	RBR
cord-017337-vq3edhxn	15	26	detailed	detailed	JJ
cord-017337-vq3edhxn	15	27	framework	framework	NN
cord-017337-vq3edhxn	15	28	which	which	WDT
cord-017337-vq3edhxn	15	29	can	can	MD
cord-017337-vq3edhxn	15	30	be	be	VB
cord-017337-vq3edhxn	15	31	used	use	VBN
cord-017337-vq3edhxn	15	32	to	to	TO
cord-017337-vq3edhxn	15	33	better	better	RB
cord-017337-vq3edhxn	15	34	characterize	characterize	VB
cord-017337-vq3edhxn	15	35	patients	patient	NNS
cord-017337-vq3edhxn	15	36	with	with	IN
cord-017337-vq3edhxn	15	37	sepsis	sepsis	NN
cord-017337-vq3edhxn	15	38	has	have	VBZ
cord-017337-vq3edhxn	15	39	been	be	VBN
cord-017337-vq3edhxn	15	40	proposed	propose	VBN
cord-017337-vq3edhxn	15	41	,	,	,
cord-017337-vq3edhxn	15	42	much	much	RB
cord-017337-vq3edhxn	15	43	as	as	IN
cord-017337-vq3edhxn	15	44	the	the	DT
cord-017337-vq3edhxn	15	45	TNM	TNM	NNP
cord-017337-vq3edhxn	15	46	classification	classification	NN
cord-017337-vq3edhxn	15	47	(	(	-LRB-
cord-017337-vq3edhxn	15	48	tumor	tumor	NN
cord-017337-vq3edhxn	15	49	size	size	NN
cord-017337-vq3edhxn	15	50	,	,	,
cord-017337-vq3edhxn	15	51	nodal	nodal	JJ
cord-017337-vq3edhxn	15	52	spread	spread	NN
cord-017337-vq3edhxn	15	53	,	,	,
cord-017337-vq3edhxn	15	54	metastases	metastasis	NNS
cord-017337-vq3edhxn	15	55	)	)	-RRB-
cord-017337-vq3edhxn	15	56	has	have	VBZ
cord-017337-vq3edhxn	15	57	been	be	VBN
cord-017337-vq3edhxn	15	58	successfully	successfully	RB
cord-017337-vq3edhxn	15	59	used	use	VBN
cord-017337-vq3edhxn	15	60	in	in	IN
cord-017337-vq3edhxn	15	61	clinical	clinical	JJ
cord-017337-vq3edhxn	15	62	oncology	oncology	NN
cord-017337-vq3edhxn	15	63	.	.	.
cord-017337-vq3edhxn	16	1	In	in	IN
cord-017337-vq3edhxn	16	2	this	this	DT
cord-017337-vq3edhxn	16	3	chapter	chapter	NN
cord-017337-vq3edhxn	16	4	,	,	,
cord-017337-vq3edhxn	16	5	we	-PRON-	PRP
cord-017337-vq3edhxn	16	6	discuss	discuss	VBP
cord-017337-vq3edhxn	16	7	the	the	DT
cord-017337-vq3edhxn	16	8	development	development	NN
cord-017337-vq3edhxn	16	9	of	of	IN
cord-017337-vq3edhxn	16	10	this	this	DT
cord-017337-vq3edhxn	16	11	PIRO	PIRO	NNP
cord-017337-vq3edhxn	16	12	system	system	NN
cord-017337-vq3edhxn	16	13	,	,	,
cord-017337-vq3edhxn	16	14	and	and	CC
cord-017337-vq3edhxn	16	15	suggest	suggest	VBP
cord-017337-vq3edhxn	16	16	how	how	WRB
cord-017337-vq3edhxn	16	17	it	-PRON-	PRP
cord-017337-vq3edhxn	16	18	may	may	MD
cord-017337-vq3edhxn	16	19	be	be	VB
cord-017337-vq3edhxn	16	20	used	use	VBN
cord-017337-vq3edhxn	16	21	in	in	IN
cord-017337-vq3edhxn	16	22	the	the	DT
cord-017337-vq3edhxn	16	23	future	future	NN
cord-017337-vq3edhxn	16	24	to	to	TO
cord-017337-vq3edhxn	16	25	aid	aid	VB
cord-017337-vq3edhxn	16	26	diagnosis	diagnosis	NN
cord-017337-vq3edhxn	16	27	,	,	,
cord-017337-vq3edhxn	16	28	guide	guide	NN
cord-017337-vq3edhxn	16	29	therapy	therapy	NN
cord-017337-vq3edhxn	16	30	,	,	,
cord-017337-vq3edhxn	16	31	and	and	CC
cord-017337-vq3edhxn	16	32	improve	improve	VB
cord-017337-vq3edhxn	16	33	prognostication	prognostication	NN
cord-017337-vq3edhxn	16	34	.	.	.
cord-017337-vq3edhxn	17	1	Over	over	IN
cord-017337-vq3edhxn	17	2	the	the	DT
cord-017337-vq3edhxn	17	3	years	year	NNS
cord-017337-vq3edhxn	17	4	,	,	,
cord-017337-vq3edhxn	17	5	there	there	EX
cord-017337-vq3edhxn	17	6	has	have	VBZ
cord-017337-vq3edhxn	17	7	been	be	VBN
cord-017337-vq3edhxn	17	8	considerable	considerable	JJ
cord-017337-vq3edhxn	17	9	confusion	confusion	NN
cord-017337-vq3edhxn	17	10	regarding	regard	VBG
cord-017337-vq3edhxn	17	11	the	the	DT
cord-017337-vq3edhxn	17	12	defi	defi	NNP
cord-017337-vq3edhxn	17	13	nition	nition	NN
cord-017337-vq3edhxn	17	14	of	of	IN
cord-017337-vq3edhxn	17	15	sepsis	sepsis	NN
cord-017337-vq3edhxn	17	16	,	,	,
cord-017337-vq3edhxn	17	17	with	with	IN
cord-017337-vq3edhxn	17	18	terms	term	NNS
cord-017337-vq3edhxn	17	19	such	such	JJ
cord-017337-vq3edhxn	17	20	as	as	IN
cord-017337-vq3edhxn	17	21	"	"	``
cord-017337-vq3edhxn	17	22	infection	infection	NN
cord-017337-vq3edhxn	17	23	"	"	''
cord-017337-vq3edhxn	17	24	and	and	CC
cord-017337-vq3edhxn	17	25	"	"	``
cord-017337-vq3edhxn	17	26	sepsis	sepsis	NN
cord-017337-vq3edhxn	17	27	"	"	''
cord-017337-vq3edhxn	17	28	often	often	RB
cord-017337-vq3edhxn	17	29	being	be	VBG
cord-017337-vq3edhxn	17	30	used	use	VBN
cord-017337-vq3edhxn	17	31	interchangeably	interchangeably	RB
cord-017337-vq3edhxn	17	32	.	.	.
cord-017337-vq3edhxn	18	1	While	while	IN
cord-017337-vq3edhxn	18	2	obviously	obviously	RB
cord-017337-vq3edhxn	18	3	related	relate	VBN
cord-017337-vq3edhxn	18	4	,	,	,
cord-017337-vq3edhxn	18	5	these	these	DT
cord-017337-vq3edhxn	18	6	elements	element	NNS
cord-017337-vq3edhxn	18	7	are	be	VBP
cord-017337-vq3edhxn	18	8	not	not	RB
cord-017337-vq3edhxn	18	9	exact	exact	JJ
cord-017337-vq3edhxn	18	10	synonyms	synonyms	NN
cord-017337-vq3edhxn	18	11	;	;	,
cord-017337-vq3edhxn	18	12	sepsis	sepsis	NN
cord-017337-vq3edhxn	18	13	is	be	VBZ
cord-017337-vq3edhxn	18	14	the	the	DT
cord-017337-vq3edhxn	18	15	host	host	NN
cord-017337-vq3edhxn	18	16	response	response	NN
cord-017337-vq3edhxn	18	17	to	to	IN
cord-017337-vq3edhxn	18	18	an	an	DT
cord-017337-vq3edhxn	18	19	infection	infection	NN
cord-017337-vq3edhxn	18	20	by	by	IN
cord-017337-vq3edhxn	18	21	an	an	DT
cord-017337-vq3edhxn	18	22	invading	invade	VBG
cord-017337-vq3edhxn	18	23	microorganism	microorganism	NN
cord-017337-vq3edhxn	18	24	,	,	,
cord-017337-vq3edhxn	18	25	be	be	VB
cord-017337-vq3edhxn	18	26	it	-PRON-	PRP
cord-017337-vq3edhxn	18	27	virus	virus	NN
cord-017337-vq3edhxn	18	28	,	,	,
cord-017337-vq3edhxn	18	29	bacteria	bacteria	NNS
cord-017337-vq3edhxn	18	30	,	,	,
cord-017337-vq3edhxn	18	31	or	or	CC
cord-017337-vq3edhxn	18	32	fungus	fungus	NN
cord-017337-vq3edhxn	18	33	.	.	.
cord-017337-vq3edhxn	19	1	In	in	IN
cord-017337-vq3edhxn	19	2	1992	1992	CD
cord-017337-vq3edhxn	19	3	,	,	,
cord-017337-vq3edhxn	19	4	as	as	IN
cord-017337-vq3edhxn	19	5	the	the	DT
cord-017337-vq3edhxn	19	6	links	link	NNS
cord-017337-vq3edhxn	19	7	between	between	IN
cord-017337-vq3edhxn	19	8	infl	infl	NN
cord-017337-vq3edhxn	19	9	ammation	ammation	NN
cord-017337-vq3edhxn	19	10	and	and	CC
cord-017337-vq3edhxn	19	11	sepsis	sepsis	NN
cord-017337-vq3edhxn	19	12	were	be	VBD
cord-017337-vq3edhxn	19	13	becoming	become	VBG
cord-017337-vq3edhxn	19	14	increasingly	increasingly	RB
cord-017337-vq3edhxn	19	15	clear	clear	JJ
cord-017337-vq3edhxn	19	16	,	,	,
cord-017337-vq3edhxn	19	17	a	a	DT
cord-017337-vq3edhxn	19	18	consensus	consensus	NN
cord-017337-vq3edhxn	19	19	conference	conference	NN
cord-017337-vq3edhxn	19	20	on	on	IN
cord-017337-vq3edhxn	19	21	sepsis	sepsis	NNP
cord-017337-vq3edhxn	19	22	defi	defi	NNP
cord-017337-vq3edhxn	19	23	nitions	nitions	NNP
cord-017337-vq3edhxn	19	24	introduced	introduce	VBD
cord-017337-vq3edhxn	19	25	the	the	DT
cord-017337-vq3edhxn	19	26	term	term	NN
cord-017337-vq3edhxn	19	27	SIRS	SIRS	NNP
cord-017337-vq3edhxn	19	28	(	(	-LRB-
cord-017337-vq3edhxn	19	29	systemic	systemic	JJ
cord-017337-vq3edhxn	19	30	infl	infl	NNP
cord-017337-vq3edhxn	19	31	ammatory	ammatory	NNP
cord-017337-vq3edhxn	19	32	response	response	NNP
cord-017337-vq3edhxn	19	33	syndrome	syndrome	NN
cord-017337-vq3edhxn	19	34	)	)	-RRB-
cord-017337-vq3edhxn	19	35	in	in	IN
cord-017337-vq3edhxn	19	36	an	an	DT
cord-017337-vq3edhxn	19	37	attempt	attempt	NN
cord-017337-vq3edhxn	19	38	to	to	TO
cord-017337-vq3edhxn	19	39	clarify	clarify	VB
cord-017337-vq3edhxn	19	40	and	and	CC
cord-017337-vq3edhxn	19	41	simplify	simplify	VB
cord-017337-vq3edhxn	19	42	the	the	DT
cord-017337-vq3edhxn	19	43	defi	defi	NNP
cord-017337-vq3edhxn	19	44	nitions	nition	NNS
cord-017337-vq3edhxn	19	45	of	of	IN
cord-017337-vq3edhxn	19	46	sepsis	sepsis	NN
cord-017337-vq3edhxn	19	47	[	[	-LRB-
cord-017337-vq3edhxn	19	48	1	1	CD
cord-017337-vq3edhxn	19	49	]	]	-RRB-
cord-017337-vq3edhxn	19	50	.	.	.
cord-017337-vq3edhxn	20	1	A	a	DT
cord-017337-vq3edhxn	20	2	patient	patient	NN
cord-017337-vq3edhxn	20	3	was	be	VBD
cord-017337-vq3edhxn	20	4	classifi	classifi	NNP
cord-017337-vq3edhxn	20	5	ed	ed	NNP
cord-017337-vq3edhxn	20	6	as	as	IN
cord-017337-vq3edhxn	20	7	having	have	VBG
cord-017337-vq3edhxn	20	8	SIRS	SIRS	NNP
cord-017337-vq3edhxn	20	9	if	if	IN
cord-017337-vq3edhxn	20	10	he	-PRON-	PRP
cord-017337-vq3edhxn	20	11	/	/	SYM
cord-017337-vq3edhxn	20	12	she	-PRON-	PRP
cord-017337-vq3edhxn	20	13	had	have	VBD
cord-017337-vq3edhxn	20	14	at	at	RB
cord-017337-vq3edhxn	20	15	least	least	RBS
cord-017337-vq3edhxn	20	16	two	two	CD
cord-017337-vq3edhxn	20	17	of	of	IN
cord-017337-vq3edhxn	20	18	four	four	CD
cord-017337-vq3edhxn	20	19	parameters	parameter	NNS
cord-017337-vq3edhxn	20	20	(	(	-LRB-
cord-017337-vq3edhxn	20	21	temperature	temperature	NN
cord-017337-vq3edhxn	20	22	>	>	XX
cord-017337-vq3edhxn	20	23	38	38	CD
cord-017337-vq3edhxn	20	24	or	or	CC
cord-017337-vq3edhxn	20	25	<	<	XX
cord-017337-vq3edhxn	20	26	36	36	CD
cord-017337-vq3edhxn	20	27	°	°	NN
cord-017337-vq3edhxn	20	28	C	c	NN
cord-017337-vq3edhxn	20	29	;	;	:
cord-017337-vq3edhxn	20	30	heart	heart	NN
cord-017337-vq3edhxn	20	31	rate	rate	NN
cord-017337-vq3edhxn	20	32	>	>	XX
cord-017337-vq3edhxn	20	33	90	90	CD
cord-017337-vq3edhxn	20	34	beats	beat	NNS
cord-017337-vq3edhxn	20	35	/	/	SYM
cord-017337-vq3edhxn	20	36	min	min	NN
cord-017337-vq3edhxn	20	37	;	;	,
cord-017337-vq3edhxn	20	38	respiratory	respiratory	JJ
cord-017337-vq3edhxn	20	39	rate	rate	NN
cord-017337-vq3edhxn	20	40	>	>	XX
cord-017337-vq3edhxn	20	41	20	20	CD
cord-017337-vq3edhxn	20	42	breaths	breath	NNS
cord-017337-vq3edhxn	20	43	per	per	IN
cord-017337-vq3edhxn	20	44	minute	minute	NN
cord-017337-vq3edhxn	20	45	or	or	CC
cord-017337-vq3edhxn	20	46	PCO	PCO	NNP
cord-017337-vq3edhxn	20	47	2	2	CD
cord-017337-vq3edhxn	20	48	<	<	XX
cord-017337-vq3edhxn	20	49	32	32	CD
cord-017337-vq3edhxn	20	50	mmHg	mmHg	NNS
cord-017337-vq3edhxn	20	51	;	;	:
cord-017337-vq3edhxn	20	52	white	white	JJ
cord-017337-vq3edhxn	20	53	blood	blood	NN
cord-017337-vq3edhxn	20	54	cell	cell	NN
cord-017337-vq3edhxn	20	55	count	count	NN
cord-017337-vq3edhxn	20	56	>	>	XX
cord-017337-vq3edhxn	21	1	12	12	CD
cord-017337-vq3edhxn	21	2	or	or	CC
cord-017337-vq3edhxn	21	3	<	<	XX
cord-017337-vq3edhxn	21	4	4	4	CD
cord-017337-vq3edhxn	21	5	×	×	NN
cord-017337-vq3edhxn	21	6	10	10	CD
cord-017337-vq3edhxn	21	7	9	9	CD
cord-017337-vq3edhxn	21	8	/l	/l	NN
cord-017337-vq3edhxn	21	9	)	)	-RRB-
cord-017337-vq3edhxn	21	10	.	.	.
cord-017337-vq3edhxn	22	1	Sepsis	sepsis	NN
cord-017337-vq3edhxn	22	2	was	be	VBD
cord-017337-vq3edhxn	22	3	defi	defi	NNP
cord-017337-vq3edhxn	22	4	ned	ned	NNP
cord-017337-vq3edhxn	22	5	as	as	IN
cord-017337-vq3edhxn	22	6	SIRS	SIRS	NNP
cord-017337-vq3edhxn	22	7	plus	plus	CC
cord-017337-vq3edhxn	22	8	infection	infection	NN
cord-017337-vq3edhxn	22	9	.	.	.
cord-017337-vq3edhxn	23	1	However	however	RB
cord-017337-vq3edhxn	23	2	,	,	,
cord-017337-vq3edhxn	23	3	it	-PRON-	PRP
cord-017337-vq3edhxn	23	4	soon	soon	RB
cord-017337-vq3edhxn	23	5	became	become	VBD
cord-017337-vq3edhxn	23	6	apparent	apparent	JJ
cord-017337-vq3edhxn	23	7	that	that	IN
cord-017337-vq3edhxn	23	8	nearly	nearly	RB
cord-017337-vq3edhxn	23	9	all	all	DT
cord-017337-vq3edhxn	23	10	intensive	intensive	JJ
cord-017337-vq3edhxn	23	11	care	care	NN
cord-017337-vq3edhxn	23	12	unit	unit	NN
cord-017337-vq3edhxn	23	13	(	(	-LRB-
cord-017337-vq3edhxn	23	14	ICU	ICU	NNP
cord-017337-vq3edhxn	23	15	)	)	-RRB-
cord-017337-vq3edhxn	23	16	patients	patient	NNS
cord-017337-vq3edhxn	23	17	meet	meet	VBP
cord-017337-vq3edhxn	23	18	the	the	DT
cord-017337-vq3edhxn	23	19	SIRS	SIRS	NNP
cord-017337-vq3edhxn	23	20	criteria	criterion	NNS
cord-017337-vq3edhxn	23	21	at	at	IN
cord-017337-vq3edhxn	23	22	some	some	DT
cord-017337-vq3edhxn	23	23	point	point	NN
cord-017337-vq3edhxn	23	24	during	during	IN
cord-017337-vq3edhxn	23	25	their	-PRON-	PRP$
cord-017337-vq3edhxn	23	26	ICU	ICU	NNP
cord-017337-vq3edhxn	23	27	stay	stay	VBP
cord-017337-vq3edhxn	23	28	[	[	-LRB-
cord-017337-vq3edhxn	23	29	2	2	CD
cord-017337-vq3edhxn	23	30	,	,	,
cord-017337-vq3edhxn	23	31	3	3	CD
cord-017337-vq3edhxn	23	32	]	]	-RRB-
cord-017337-vq3edhxn	23	33	,	,	,
cord-017337-vq3edhxn	23	34	making	make	VBG
cord-017337-vq3edhxn	23	35	this	this	DT
cord-017337-vq3edhxn	23	36	approach	approach	NN
cord-017337-vq3edhxn	23	37	too	too	RB
cord-017337-vq3edhxn	23	38	sensitive	sensitive	JJ
cord-017337-vq3edhxn	23	39	to	to	TO
cord-017337-vq3edhxn	23	40	be	be	VB
cord-017337-vq3edhxn	23	41	useful	useful	JJ
cord-017337-vq3edhxn	23	42	in	in	IN
cord-017337-vq3edhxn	23	43	diagnosing	diagnose	VBG
cord-017337-vq3edhxn	23	44	sepsis	sepsis	NN
cord-017337-vq3edhxn	23	45	[	[	-LRB-
cord-017337-vq3edhxn	23	46	4	4	CD
cord-017337-vq3edhxn	23	47	]	]	-RRB-
cord-017337-vq3edhxn	23	48	.	.	.
cord-017337-vq3edhxn	24	1	Almost	almost	RB
cord-017337-vq3edhxn	24	2	10	10	CD
cord-017337-vq3edhxn	24	3	years	year	NNS
cord-017337-vq3edhxn	24	4	later	later	RB
cord-017337-vq3edhxn	24	5	,	,	,
cord-017337-vq3edhxn	24	6	a	a	DT
cord-017337-vq3edhxn	24	7	second	second	JJ
cord-017337-vq3edhxn	24	8	consensus	consensus	NN
cord-017337-vq3edhxn	24	9	conference	conference	NN
cord-017337-vq3edhxn	24	10	on	on	IN
cord-017337-vq3edhxn	24	11	sepsis	sepsis	NNP
cord-017337-vq3edhxn	24	12	defi	defi	NNP
cord-017337-vq3edhxn	24	13	nitions	nitions	NNP
cord-017337-vq3edhxn	24	14	was	be	VBD
cord-017337-vq3edhxn	24	15	convened	convene	VBN
cord-017337-vq3edhxn	24	16	,	,	,
cord-017337-vq3edhxn	24	17	sponsored	sponsor	VBN
cord-017337-vq3edhxn	24	18	by	by	IN
cord-017337-vq3edhxn	24	19	the	the	DT
cord-017337-vq3edhxn	24	20	Society	Society	NNP
cord-017337-vq3edhxn	24	21	of	of	IN
cord-017337-vq3edhxn	24	22	Critical	Critical	NNP
cord-017337-vq3edhxn	24	23	Care	Care	NNP
cord-017337-vq3edhxn	24	24	Medicine	Medicine	NNP
cord-017337-vq3edhxn	24	25	(	(	-LRB-
cord-017337-vq3edhxn	24	26	SCCM	SCCM	NNP
cord-017337-vq3edhxn	24	27	)	)	-RRB-
cord-017337-vq3edhxn	24	28	,	,	,
cord-017337-vq3edhxn	24	29	the	the	DT
cord-017337-vq3edhxn	24	30	European	European	NNP
cord-017337-vq3edhxn	24	31	Society	Society	NNP
cord-017337-vq3edhxn	24	32	of	of	IN
cord-017337-vq3edhxn	24	33	Intensive	Intensive	NNP
cord-017337-vq3edhxn	24	34	Care	Care	NNP
cord-017337-vq3edhxn	24	35	Medicine	Medicine	NNP
cord-017337-vq3edhxn	24	36	(	(	-LRB-
cord-017337-vq3edhxn	24	37	ESICM	ESICM	NNP
cord-017337-vq3edhxn	24	38	)	)	-RRB-
cord-017337-vq3edhxn	24	39	,	,	,
cord-017337-vq3edhxn	24	40	the	the	DT
cord-017337-vq3edhxn	24	41	American	American	NNP
cord-017337-vq3edhxn	24	42	College	College	NNP
cord-017337-vq3edhxn	24	43	of	of	IN
cord-017337-vq3edhxn	24	44	Chest	Chest	NNP
cord-017337-vq3edhxn	24	45	Physicians	Physicians	NNPS
cord-017337-vq3edhxn	24	46	(	(	-LRB-
cord-017337-vq3edhxn	24	47	ACCP	ACCP	NNP
cord-017337-vq3edhxn	24	48	)	)	-RRB-
cord-017337-vq3edhxn	24	49	,	,	,
cord-017337-vq3edhxn	24	50	the	the	DT
cord-017337-vq3edhxn	24	51	American	American	NNP
cord-017337-vq3edhxn	24	52	Thoracic	Thoracic	NNP
cord-017337-vq3edhxn	24	53	Society	Society	NNP
cord-017337-vq3edhxn	24	54	(	(	-LRB-
cord-017337-vq3edhxn	24	55	ATS	ATS	NNP
cord-017337-vq3edhxn	24	56	)	)	-RRB-
cord-017337-vq3edhxn	24	57	,	,	,
cord-017337-vq3edhxn	24	58	and	and	CC
cord-017337-vq3edhxn	24	59	the	the	DT
cord-017337-vq3edhxn	24	60	Surgical	surgical	JJ
cord-017337-vq3edhxn	24	61	Infection	infection	NN
cord-017337-vq3edhxn	24	62	Societies	Societies	NNPS
cord-017337-vq3edhxn	24	63	(	(	-LRB-
cord-017337-vq3edhxn	24	64	SIS	SIS	NNP
cord-017337-vq3edhxn	24	65	)	)	-RRB-
cord-017337-vq3edhxn	25	1	[	[	-LRB-
cord-017337-vq3edhxn	25	2	5	5	CD
cord-017337-vq3edhxn	25	3	]	]	-RRB-
cord-017337-vq3edhxn	25	4	.	.	.
cord-017337-vq3edhxn	26	1	The	the	DT
cord-017337-vq3edhxn	26	2	participants	participant	NNS
cord-017337-vq3edhxn	26	3	at	at	IN
cord-017337-vq3edhxn	26	4	this	this	DT
cord-017337-vq3edhxn	26	5	meeting	meeting	NN
cord-017337-vq3edhxn	26	6	agreed	agree	VBD
cord-017337-vq3edhxn	26	7	that	that	IN
cord-017337-vq3edhxn	26	8	the	the	DT
cord-017337-vq3edhxn	26	9	SIRS	SIRS	NNP
cord-017337-vq3edhxn	26	10	concept	concept	NN
cord-017337-vq3edhxn	26	11	was	be	VBD
cord-017337-vq3edhxn	26	12	not	not	RB
cord-017337-vq3edhxn	26	13	helpful	helpful	JJ
cord-017337-vq3edhxn	26	14	and	and	CC
cord-017337-vq3edhxn	26	15	should	should	MD
cord-017337-vq3edhxn	26	16	no	no	RB
cord-017337-vq3edhxn	26	17	longer	longer	RB
cord-017337-vq3edhxn	26	18	be	be	VB
cord-017337-vq3edhxn	26	19	used	use	VBN
cord-017337-vq3edhxn	26	20	per	per	IN
cord-017337-vq3edhxn	26	21	se	se	FW
cord-017337-vq3edhxn	26	22	,	,	,
cord-017337-vq3edhxn	26	23	but	but	CC
cord-017337-vq3edhxn	26	24	that	that	IN
cord-017337-vq3edhxn	26	25	the	the	DT
cord-017337-vq3edhxn	26	26	SIRS	SIRS	NNP
cord-017337-vq3edhxn	26	27	criteria	criterion	NNS
cord-017337-vq3edhxn	26	28	be	be	VB
cord-017337-vq3edhxn	26	29	incorporated	incorporate	VBN
cord-017337-vq3edhxn	26	30	into	into	IN
cord-017337-vq3edhxn	26	31	a	a	DT
cord-017337-vq3edhxn	26	32	longer	long	JJR
cord-017337-vq3edhxn	26	33	list	list	NN
cord-017337-vq3edhxn	26	34	of	of	IN
cord-017337-vq3edhxn	26	35	signs	sign	NNS
cord-017337-vq3edhxn	26	36	of	of	IN
cord-017337-vq3edhxn	26	37	sepsis	sepsis	NN
cord-017337-vq3edhxn	26	38	that	that	WDT
cord-017337-vq3edhxn	26	39	could	could	MD
cord-017337-vq3edhxn	26	40	be	be	VB
cord-017337-vq3edhxn	26	41	employed	employ	VBN
cord-017337-vq3edhxn	26	42	to	to	TO
cord-017337-vq3edhxn	26	43	support	support	VB
cord-017337-vq3edhxn	26	44	a	a	DT
cord-017337-vq3edhxn	26	45	diagnosis	diagnosis	NN
cord-017337-vq3edhxn	26	46	of	of	IN
cord-017337-vq3edhxn	26	47	sepsis	sepsis	NN
cord-017337-vq3edhxn	26	48	.	.	.
cord-017337-vq3edhxn	27	1	This	this	DT
cord-017337-vq3edhxn	27	2	list	list	NN
cord-017337-vq3edhxn	27	3	includes	include	VBZ
cord-017337-vq3edhxn	27	4	biologic	biologic	JJ
cord-017337-vq3edhxn	27	5	signs	sign	NNS
cord-017337-vq3edhxn	27	6	of	of	IN
cord-017337-vq3edhxn	27	7	infl	infl	NN
cord-017337-vq3edhxn	27	8	ammation	ammation	NNP
cord-017337-vq3edhxn	27	9	(	(	-LRB-
cord-017337-vq3edhxn	27	10	e.g.	e.g.	RB
cord-017337-vq3edhxn	27	11	,	,	,
cord-017337-vq3edhxn	27	12	increased	increase	VBN
cord-017337-vq3edhxn	27	13	serum	serum	NN
cord-017337-vq3edhxn	27	14	concentrations	concentration	NNS
cord-017337-vq3edhxn	27	15	of	of	IN
cord-017337-vq3edhxn	27	16	C	c	NN
cord-017337-vq3edhxn	27	17	-	-	HYPH
cord-017337-vq3edhxn	27	18	reactive	reactive	JJ
cord-017337-vq3edhxn	27	19	protein	protein	NN
cord-017337-vq3edhxn	27	20	[	[	-LRB-
cord-017337-vq3edhxn	27	21	CRP	CRP	NNP
cord-017337-vq3edhxn	27	22	]	]	-RRB-
cord-017337-vq3edhxn	27	23	or	or	CC
cord-017337-vq3edhxn	27	24	procalcitonin	procalcitonin	NNS
cord-017337-vq3edhxn	27	25	)	)	-RRB-
cord-017337-vq3edhxn	27	26	,	,	,
cord-017337-vq3edhxn	27	27	hemodynamic	hemodynamic	JJ
cord-017337-vq3edhxn	27	28	parameters	parameter	NNS
cord-017337-vq3edhxn	27	29	(	(	-LRB-
cord-017337-vq3edhxn	27	30	e.g.	e.g.	RB
cord-017337-vq3edhxn	27	31	,	,	,
cord-017337-vq3edhxn	27	32	increased	increase	VBN
cord-017337-vq3edhxn	27	33	cardiac	cardiac	JJ
cord-017337-vq3edhxn	27	34	output	output	NN
cord-017337-vq3edhxn	27	35	,	,	,
cord-017337-vq3edhxn	27	36	low	low	JJ
cord-017337-vq3edhxn	27	37	systemic	systemic	JJ
cord-017337-vq3edhxn	27	38	vascular	vascular	JJ
cord-017337-vq3edhxn	27	39	resistance	resistance	NN
cord-017337-vq3edhxn	27	40	[	[	-LRB-
cord-017337-vq3edhxn	27	41	SVR	SVR	NNP
cord-017337-vq3edhxn	27	42	]	]	-RRB-
cord-017337-vq3edhxn	27	43	,	,	,
cord-017337-vq3edhxn	27	44	low	low	JJ
cord-017337-vq3edhxn	27	45	oxygen	oxygen	NN
cord-017337-vq3edhxn	27	46	extraction	extraction	NN
cord-017337-vq3edhxn	27	47	ratio	ratio	NN
cord-017337-vq3edhxn	27	48	)	)	-RRB-
cord-017337-vq3edhxn	27	49	,	,	,
cord-017337-vq3edhxn	27	50	signs	sign	NNS
cord-017337-vq3edhxn	27	51	of	of	IN
cord-017337-vq3edhxn	27	52	altered	alter	VBN
cord-017337-vq3edhxn	27	53	tissue	tissue	NN
cord-017337-vq3edhxn	27	54	perfusion	perfusion	NN
cord-017337-vq3edhxn	27	55	(	(	-LRB-
cord-017337-vq3edhxn	27	56	e.g.	e.g.	RB
cord-017337-vq3edhxn	27	57	,	,	,
cord-017337-vq3edhxn	27	58	altered	alter	VBN
cord-017337-vq3edhxn	27	59	skin	skin	NN
cord-017337-vq3edhxn	27	60	perfusion	perfusion	NN
cord-017337-vq3edhxn	27	61	,	,	,
cord-017337-vq3edhxn	27	62	reduced	reduce	VBN
cord-017337-vq3edhxn	27	63	urine	urine	NN
cord-017337-vq3edhxn	27	64	output	output	NN
cord-017337-vq3edhxn	27	65	)	)	-RRB-
cord-017337-vq3edhxn	27	66	,	,	,
cord-017337-vq3edhxn	27	67	and	and	CC
cord-017337-vq3edhxn	27	68	signs	sign	NNS
cord-017337-vq3edhxn	27	69	of	of	IN
cord-017337-vq3edhxn	27	70	organ	organ	NN
cord-017337-vq3edhxn	27	71	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	27	72	(	(	-LRB-
cord-017337-vq3edhxn	27	73	e.g.	e.g.	RB
cord-017337-vq3edhxn	27	74	,	,	,
cord-017337-vq3edhxn	27	75	increased	increase	VBN
cord-017337-vq3edhxn	27	76	urea	urea	NN
cord-017337-vq3edhxn	27	77	and	and	CC
cord-017337-vq3edhxn	27	78	creatinine	creatinine	NN
cord-017337-vq3edhxn	27	79	,	,	,
cord-017337-vq3edhxn	27	80	low	low	JJ
cord-017337-vq3edhxn	27	81	platelet	platelet	NN
cord-017337-vq3edhxn	27	82	count	count	NN
cord-017337-vq3edhxn	27	83	or	or	CC
cord-017337-vq3edhxn	27	84	other	other	JJ
cord-017337-vq3edhxn	27	85	coagulation	coagulation	NN
cord-017337-vq3edhxn	27	86	abnormalities	abnormality	NNS
cord-017337-vq3edhxn	27	87	,	,	,
cord-017337-vq3edhxn	27	88	1	1	CD
cord-017337-vq3edhxn	27	89	hyperbilirubinemia	hyperbilirubinemia	NN
cord-017337-vq3edhxn	27	90	)	)	-RRB-
cord-017337-vq3edhxn	27	91	.	.	.
cord-017337-vq3edhxn	28	1	The	the	DT
cord-017337-vq3edhxn	28	2	participants	participant	NNS
cord-017337-vq3edhxn	28	3	also	also	RB
cord-017337-vq3edhxn	28	4	suggested	suggest	VBD
cord-017337-vq3edhxn	28	5	that	that	IN
cord-017337-vq3edhxn	28	6	as	as	IN
cord-017337-vq3edhxn	28	7	the	the	DT
cord-017337-vq3edhxn	28	8	defi	defi	NNP
cord-017337-vq3edhxn	28	9	nitions	nitions	NNP
cord-017337-vq3edhxn	28	10	did	do	VBD
cord-017337-vq3edhxn	28	11	not	not	RB
cord-017337-vq3edhxn	28	12	allow	allow	VB
cord-017337-vq3edhxn	28	13	for	for	IN
cord-017337-vq3edhxn	28	14	precise	precise	JJ
cord-017337-vq3edhxn	28	15	characterization	characterization	NN
cord-017337-vq3edhxn	28	16	and	and	CC
cord-017337-vq3edhxn	28	17	staging	staging	NN
cord-017337-vq3edhxn	28	18	of	of	IN
cord-017337-vq3edhxn	28	19	patients	patient	NNS
cord-017337-vq3edhxn	28	20	with	with	IN
cord-017337-vq3edhxn	28	21	sepsis	sepsis	NN
cord-017337-vq3edhxn	28	22	,	,	,
cord-017337-vq3edhxn	28	23	a	a	DT
cord-017337-vq3edhxn	28	24	clinically	clinically	RB
cord-017337-vq3edhxn	28	25	useful	useful	JJ
cord-017337-vq3edhxn	28	26	staging	staging	NN
cord-017337-vq3edhxn	28	27	system	system	NN
cord-017337-vq3edhxn	28	28	that	that	WDT
cord-017337-vq3edhxn	28	29	could	could	MD
cord-017337-vq3edhxn	28	30	stratify	stratify	VB
cord-017337-vq3edhxn	28	31	patients	patient	NNS
cord-017337-vq3edhxn	28	32	by	by	IN
cord-017337-vq3edhxn	28	33	both	both	DT
cord-017337-vq3edhxn	28	34	their	-PRON-	PRP$
cord-017337-vq3edhxn	28	35	baseline	baseline	JJ
cord-017337-vq3edhxn	28	36	risk	risk	NN
cord-017337-vq3edhxn	28	37	of	of	IN
cord-017337-vq3edhxn	28	38	an	an	DT
cord-017337-vq3edhxn	28	39	adverse	adverse	JJ
cord-017337-vq3edhxn	28	40	outcome	outcome	NN
cord-017337-vq3edhxn	28	41	and	and	CC
cord-017337-vq3edhxn	28	42	their	-PRON-	PRP$
cord-017337-vq3edhxn	28	43	potential	potential	NN
cord-017337-vq3edhxn	28	44	to	to	TO
cord-017337-vq3edhxn	28	45	respond	respond	VB
cord-017337-vq3edhxn	28	46	to	to	IN
cord-017337-vq3edhxn	28	47	therapy	therapy	NN
cord-017337-vq3edhxn	28	48	was	be	VBD
cord-017337-vq3edhxn	28	49	needed	need	VBN
cord-017337-vq3edhxn	28	50	.	.	.
cord-017337-vq3edhxn	29	1	Building	build	VBG
cord-017337-vq3edhxn	29	2	on	on	IN
cord-017337-vq3edhxn	29	3	a	a	DT
cord-017337-vq3edhxn	29	4	system	system	NN
cord-017337-vq3edhxn	29	5	that	that	WDT
cord-017337-vq3edhxn	29	6	had	have	VBD
cord-017337-vq3edhxn	29	7	emerged	emerge	VBN
cord-017337-vq3edhxn	29	8	at	at	IN
cord-017337-vq3edhxn	29	9	the	the	DT
cord-017337-vq3edhxn	29	10	Fifth	Fifth	NNP
cord-017337-vq3edhxn	29	11	Toronto	Toronto	NNP
cord-017337-vq3edhxn	29	12	Sepsis	Sepsis	NNP
cord-017337-vq3edhxn	29	13	Roundtable	Roundtable	NNP
cord-017337-vq3edhxn	29	14	held	hold	VBN
cord-017337-vq3edhxn	29	15	in	in	IN
cord-017337-vq3edhxn	29	16	Toronto	Toronto	NNP
cord-017337-vq3edhxn	29	17	,	,	,
cord-017337-vq3edhxn	29	18	Canada	Canada	NNP
cord-017337-vq3edhxn	29	19	,	,	,
cord-017337-vq3edhxn	29	20	in	in	IN
cord-017337-vq3edhxn	29	21	2000	2000	CD
cord-017337-vq3edhxn	29	22	[	[	-LRB-
cord-017337-vq3edhxn	29	23	6	6	CD
cord-017337-vq3edhxn	29	24	]	]	-RRB-
cord-017337-vq3edhxn	29	25	,	,	,
cord-017337-vq3edhxn	29	26	the	the	DT
cord-017337-vq3edhxn	29	27	sepsis	sepsis	NN
cord-017337-vq3edhxn	29	28	defi	defi	NNP
cord-017337-vq3edhxn	29	29	nitions	nitions	NNP
cord-017337-vq3edhxn	29	30	conference	conference	NN
cord-017337-vq3edhxn	29	31	participants	participant	NNS
cord-017337-vq3edhxn	29	32	,	,	,
cord-017337-vq3edhxn	29	33	therefore	therefore	RB
cord-017337-vq3edhxn	29	34	,	,	,
cord-017337-vq3edhxn	29	35	proposed	propose	VBD
cord-017337-vq3edhxn	29	36	the	the	DT
cord-017337-vq3edhxn	29	37	PIRO	PIRO	NNP
cord-017337-vq3edhxn	29	38	system	system	NN
cord-017337-vq3edhxn	29	39	[	[	-LRB-
cord-017337-vq3edhxn	29	40	5	5	CD
cord-017337-vq3edhxn	29	41	]	]	-RRB-
cord-017337-vq3edhxn	29	42	,	,	,
cord-017337-vq3edhxn	29	43	which	which	WDT
cord-017337-vq3edhxn	29	44	can	can	MD
cord-017337-vq3edhxn	29	45	classify	classify	VB
cord-017337-vq3edhxn	29	46	patients	patient	NNS
cord-017337-vq3edhxn	29	47	on	on	IN
cord-017337-vq3edhxn	29	48	the	the	DT
cord-017337-vq3edhxn	29	49	basis	basis	NN
cord-017337-vq3edhxn	29	50	of	of	IN
cord-017337-vq3edhxn	29	51	their	-PRON-	PRP$
cord-017337-vq3edhxn	29	52	predisposing	predisposing	JJ
cord-017337-vq3edhxn	29	53	conditions	condition	NNS
cord-017337-vq3edhxn	29	54	,	,	,
cord-017337-vq3edhxn	29	55	the	the	DT
cord-017337-vq3edhxn	29	56	nature	nature	NN
cord-017337-vq3edhxn	29	57	and	and	CC
cord-017337-vq3edhxn	29	58	extent	extent	NN
cord-017337-vq3edhxn	29	59	of	of	IN
cord-017337-vq3edhxn	29	60	the	the	DT
cord-017337-vq3edhxn	29	61	infection	infection	NN
cord-017337-vq3edhxn	29	62	,	,	,
cord-017337-vq3edhxn	29	63	the	the	DT
cord-017337-vq3edhxn	29	64	nature	nature	NN
cord-017337-vq3edhxn	29	65	and	and	CC
cord-017337-vq3edhxn	29	66	magnitude	magnitude	NN
cord-017337-vq3edhxn	29	67	of	of	IN
cord-017337-vq3edhxn	29	68	the	the	DT
cord-017337-vq3edhxn	29	69	host	host	NN
cord-017337-vq3edhxn	29	70	response	response	NN
cord-017337-vq3edhxn	29	71	,	,	,
cord-017337-vq3edhxn	29	72	and	and	CC
cord-017337-vq3edhxn	29	73	the	the	DT
cord-017337-vq3edhxn	29	74	degree	degree	NN
cord-017337-vq3edhxn	29	75	of	of	IN
cord-017337-vq3edhxn	29	76	concomitant	concomitant	JJ
cord-017337-vq3edhxn	29	77	organ	organ	NN
cord-017337-vq3edhxn	29	78	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	29	79	.	.	.
cord-017337-vq3edhxn	30	1	Disease	Disease	NNP
cord-017337-vq3edhxn	30	2	stratifi	stratifi	NN
cord-017337-vq3edhxn	30	3	cations	cation	NNS
cord-017337-vq3edhxn	30	4	systems	system	NNS
cord-017337-vq3edhxn	30	5	are	be	VBP
cord-017337-vq3edhxn	30	6	widely	widely	RB
cord-017337-vq3edhxn	30	7	used	use	VBN
cord-017337-vq3edhxn	30	8	in	in	IN
cord-017337-vq3edhxn	30	9	clinical	clinical	JJ
cord-017337-vq3edhxn	30	10	medicine	medicine	NN
cord-017337-vq3edhxn	30	11	,	,	,
cord-017337-vq3edhxn	30	12	but	but	CC
cord-017337-vq3edhxn	30	13	perhaps	perhaps	RB
cord-017337-vq3edhxn	30	14	the	the	DT
cord-017337-vq3edhxn	30	15	most	most	RBS
cord-017337-vq3edhxn	30	16	familiar	familiar	JJ
cord-017337-vq3edhxn	30	17	and	and	CC
cord-017337-vq3edhxn	30	18	frequently	frequently	RB
cord-017337-vq3edhxn	30	19	employed	employ	VBN
cord-017337-vq3edhxn	30	20	is	be	VBZ
cord-017337-vq3edhxn	30	21	the	the	DT
cord-017337-vq3edhxn	30	22	TNM	TNM	NNP
cord-017337-vq3edhxn	30	23	system	system	NN
cord-017337-vq3edhxn	30	24	,	,	,
cord-017337-vq3edhxn	30	25	which	which	WDT
cord-017337-vq3edhxn	30	26	was	be	VBD
cord-017337-vq3edhxn	30	27	developed	develop	VBN
cord-017337-vq3edhxn	30	28	by	by	IN
cord-017337-vq3edhxn	30	29	Pierre	Pierre	NNP
cord-017337-vq3edhxn	30	30	Denoix	Denoix	NNP
cord-017337-vq3edhxn	30	31	in	in	IN
cord-017337-vq3edhxn	30	32	the	the	DT
cord-017337-vq3edhxn	30	33	1940s	1940	NNS
cord-017337-vq3edhxn	30	34	[	[	-LRB-
cord-017337-vq3edhxn	30	35	7	7	CD
cord-017337-vq3edhxn	30	36	]	]	-RRB-
cord-017337-vq3edhxn	30	37	,	,	,
cord-017337-vq3edhxn	30	38	and	and	CC
cord-017337-vq3edhxn	30	39	is	be	VBZ
cord-017337-vq3edhxn	30	40	universally	universally	RB
cord-017337-vq3edhxn	30	41	recognized	recognize	VBN
cord-017337-vq3edhxn	30	42	as	as	IN
cord-017337-vq3edhxn	30	43	a	a	DT
cord-017337-vq3edhxn	30	44	standard	standard	NN
cord-017337-vq3edhxn	30	45	for	for	IN
cord-017337-vq3edhxn	30	46	classifying	classify	VBG
cord-017337-vq3edhxn	30	47	patients	patient	NNS
cord-017337-vq3edhxn	30	48	with	with	IN
cord-017337-vq3edhxn	30	49	cancer	cancer	NN
cord-017337-vq3edhxn	30	50	.	.	.
cord-017337-vq3edhxn	31	1	The	the	DT
cord-017337-vq3edhxn	31	2	TNM	TNM	NNP
cord-017337-vq3edhxn	31	3	system	system	NN
cord-017337-vq3edhxn	31	4	classifi	classifi	NNP
cord-017337-vq3edhxn	31	5	es	es	XX
cord-017337-vq3edhxn	31	6	malignant	malignant	JJ
cord-017337-vq3edhxn	31	7	tumors	tumor	NNS
cord-017337-vq3edhxn	31	8	based	base	VBN
cord-017337-vq3edhxn	31	9	on	on	IN
cord-017337-vq3edhxn	31	10	descriptors	descriptor	NNS
cord-017337-vq3edhxn	31	11	of	of	IN
cord-017337-vq3edhxn	31	12	the	the	DT
cord-017337-vq3edhxn	31	13	extent	extent	NN
cord-017337-vq3edhxn	31	14	of	of	IN
cord-017337-vq3edhxn	31	15	the	the	DT
cord-017337-vq3edhxn	31	16	primary	primary	JJ
cord-017337-vq3edhxn	31	17	tumor	tumor	NN
cord-017337-vq3edhxn	31	18	(	(	-LRB-
cord-017337-vq3edhxn	31	19	T	T	NNP
cord-017337-vq3edhxn	31	20	)	)	-RRB-
cord-017337-vq3edhxn	31	21	,	,	,
cord-017337-vq3edhxn	31	22	on	on	IN
cord-017337-vq3edhxn	31	23	the	the	DT
cord-017337-vq3edhxn	31	24	presence	presence	NN
cord-017337-vq3edhxn	31	25	,	,	,
cord-017337-vq3edhxn	31	26	absence	absence	NN
cord-017337-vq3edhxn	31	27	,	,	,
cord-017337-vq3edhxn	31	28	and	and	CC
cord-017337-vq3edhxn	31	29	extent	extent	NN
cord-017337-vq3edhxn	31	30	of	of	IN
cord-017337-vq3edhxn	31	31	metastases	metastasis	NNS
cord-017337-vq3edhxn	31	32	to	to	IN
cord-017337-vq3edhxn	31	33	regional	regional	JJ
cord-017337-vq3edhxn	31	34	lymph	lymph	NN
cord-017337-vq3edhxn	31	35	nodes	node	NNS
cord-017337-vq3edhxn	31	36	(	(	-LRB-
cord-017337-vq3edhxn	31	37	N	N	NNP
cord-017337-vq3edhxn	31	38	)	)	-RRB-
cord-017337-vq3edhxn	31	39	,	,	,
cord-017337-vq3edhxn	31	40	and	and	CC
cord-017337-vq3edhxn	31	41	on	on	IN
cord-017337-vq3edhxn	31	42	the	the	DT
cord-017337-vq3edhxn	31	43	presence	presence	NN
cord-017337-vq3edhxn	31	44	or	or	CC
cord-017337-vq3edhxn	31	45	absence	absence	NN
cord-017337-vq3edhxn	31	46	of	of	IN
cord-017337-vq3edhxn	31	47	distant	distant	JJ
cord-017337-vq3edhxn	31	48	metastases	metastasis	NNS
cord-017337-vq3edhxn	31	49	(	(	-LRB-
cord-017337-vq3edhxn	31	50	M	M	NNP
cord-017337-vq3edhxn	31	51	)	)	-RRB-
cord-017337-vq3edhxn	32	1	(	(	-LRB-
cord-017337-vq3edhxn	32	2	Table	table	NN
cord-017337-vq3edhxn	32	3	1	1	CD
cord-017337-vq3edhxn	32	4	)	)	-RRB-
cord-017337-vq3edhxn	32	5	.	.	.
cord-017337-vq3edhxn	33	1	Each	each	DT
cord-017337-vq3edhxn	33	2	patient	patient	JJ
cord-017337-vq3edhxn	33	3	with	with	IN
cord-017337-vq3edhxn	33	4	a	a	DT
cord-017337-vq3edhxn	33	5	tumor	tumor	NN
cord-017337-vq3edhxn	33	6	will	will	MD
cord-017337-vq3edhxn	33	7	,	,	,
cord-017337-vq3edhxn	33	8	therefore	therefore	RB
cord-017337-vq3edhxn	33	9	,	,	,
cord-017337-vq3edhxn	33	10	receive	receive	VB
cord-017337-vq3edhxn	33	11	a	a	DT
cord-017337-vq3edhxn	33	12	specifi	specifi	NN
cord-017337-vq3edhxn	33	13	c	c	NNP
cord-017337-vq3edhxn	33	14	classifi	classifi	NNP
cord-017337-vq3edhxn	33	15	cation	cation	NNP
cord-017337-vq3edhxn	33	16	,	,	,
cord-017337-vq3edhxn	33	17	e.g.	e.g.	RB
cord-017337-vq3edhxn	33	18	,	,	,
cord-017337-vq3edhxn	33	19	T1	T1	NNP
cord-017337-vq3edhxn	33	20	,	,	,
cord-017337-vq3edhxn	33	21	N0	N0	NNP
cord-017337-vq3edhxn	33	22	,	,	,
cord-017337-vq3edhxn	33	23	M0	m0	NN
cord-017337-vq3edhxn	33	24	,	,	,
cord-017337-vq3edhxn	33	25	for	for	IN
cord-017337-vq3edhxn	33	26	that	that	DT
cord-017337-vq3edhxn	33	27	tumor	tumor	NN
cord-017337-vq3edhxn	33	28	.	.	.
cord-017337-vq3edhxn	34	1	TNM	TNM	NNP
cord-017337-vq3edhxn	34	2	classifi	classifi	NNP
cord-017337-vq3edhxn	34	3	cations	cation	NNS
cord-017337-vq3edhxn	34	4	are	be	VBP
cord-017337-vq3edhxn	34	5	then	then	RB
cord-017337-vq3edhxn	34	6	grouped	group	VBN
cord-017337-vq3edhxn	34	7	into	into	IN
cord-017337-vq3edhxn	34	8	stages	stage	NNS
cord-017337-vq3edhxn	34	9	,	,	,
cord-017337-vq3edhxn	34	10	usually	usually	RB
cord-017337-vq3edhxn	34	11	from	from	IN
cord-017337-vq3edhxn	34	12	I	-PRON-	PRP
cord-017337-vq3edhxn	34	13	to	to	IN
cord-017337-vq3edhxn	34	14	IV	IV	NNP
cord-017337-vq3edhxn	34	15	,	,	,
cord-017337-vq3edhxn	34	16	which	which	WDT
cord-017337-vq3edhxn	34	17	provide	provide	VBP
cord-017337-vq3edhxn	34	18	valuable	valuable	JJ
cord-017337-vq3edhxn	34	19	prognostic	prognostic	JJ
cord-017337-vq3edhxn	34	20	information	information	NN
cord-017337-vq3edhxn	34	21	.	.	.
cord-017337-vq3edhxn	35	1	Importantly	importantly	RB
cord-017337-vq3edhxn	35	2	,	,	,
cord-017337-vq3edhxn	35	3	staging	stage	VBG
cord-017337-vq3edhxn	35	4	systems	system	NNS
cord-017337-vq3edhxn	35	5	in	in	IN
cord-017337-vq3edhxn	35	6	cancer	cancer	NN
cord-017337-vq3edhxn	35	7	stratify	stratify	VBP
cord-017337-vq3edhxn	35	8	patients	patient	NNS
cord-017337-vq3edhxn	35	9	not	not	RB
cord-017337-vq3edhxn	35	10	only	only	RB
cord-017337-vq3edhxn	35	11	according	accord	VBG
cord-017337-vq3edhxn	35	12	to	to	IN
cord-017337-vq3edhxn	35	13	prognosis	prognosis	NN
cord-017337-vq3edhxn	35	14	,	,	,
cord-017337-vq3edhxn	35	15	but	but	CC
cord-017337-vq3edhxn	35	16	also	also	RB
cord-017337-vq3edhxn	35	17	according	accord	VBG
cord-017337-vq3edhxn	35	18	to	to	IN
cord-017337-vq3edhxn	35	19	the	the	DT
cord-017337-vq3edhxn	35	20	probability	probability	NN
cord-017337-vq3edhxn	35	21	that	that	IN
cord-017337-vq3edhxn	35	22	they	-PRON-	PRP
cord-017337-vq3edhxn	35	23	will	will	MD
cord-017337-vq3edhxn	35	24	respond	respond	VB
cord-017337-vq3edhxn	35	25	to	to	IN
cord-017337-vq3edhxn	35	26	a	a	DT
cord-017337-vq3edhxn	35	27	particular	particular	JJ
cord-017337-vq3edhxn	35	28	therapy	therapy	NN
cord-017337-vq3edhxn	35	29	.	.	.
cord-017337-vq3edhxn	36	1	Sepsis	sepsis	NN
cord-017337-vq3edhxn	36	2	is	be	VBZ
cord-017337-vq3edhxn	36	3	in	in	IN
cord-017337-vq3edhxn	36	4	many	many	JJ
cord-017337-vq3edhxn	36	5	ways	way	NNS
cord-017337-vq3edhxn	36	6	very	very	RB
cord-017337-vq3edhxn	36	7	similar	similar	JJ
cord-017337-vq3edhxn	36	8	to	to	IN
cord-017337-vq3edhxn	36	9	cancer	cancer	NN
cord-017337-vq3edhxn	36	10	.	.	.
cord-017337-vq3edhxn	37	1	Both	both	DT
cord-017337-vq3edhxn	37	2	disease	disease	NN
cord-017337-vq3edhxn	37	3	processes	process	NNS
cord-017337-vq3edhxn	37	4	are	be	VBP
cord-017337-vq3edhxn	37	5	common	common	JJ
cord-017337-vq3edhxn	37	6	,	,	,
cord-017337-vq3edhxn	37	7	with	with	IN
cord-017337-vq3edhxn	37	8	high	high	JJ
cord-017337-vq3edhxn	37	9	mortality	mortality	NN
cord-017337-vq3edhxn	37	10	rates	rate	NNS
cord-017337-vq3edhxn	37	11	.	.	.
cord-017337-vq3edhxn	38	1	Both	both	DT
cord-017337-vq3edhxn	38	2	are	be	VBP
cord-017337-vq3edhxn	38	3	the	the	DT
cord-017337-vq3edhxn	38	4	result	result	NN
cord-017337-vq3edhxn	38	5	of	of	IN
cord-017337-vq3edhxn	38	6	a	a	DT
cord-017337-vq3edhxn	38	7	complex	complex	JJ
cord-017337-vq3edhxn	38	8	pathophysiological	pathophysiological	JJ
cord-017337-vq3edhxn	38	9	process	process	NN
cord-017337-vq3edhxn	38	10	involving	involve	VBG
cord-017337-vq3edhxn	38	11	cellular	cellular	JJ
cord-017337-vq3edhxn	38	12	dysregulation	dysregulation	NN
cord-017337-vq3edhxn	38	13	.	.	.
cord-017337-vq3edhxn	39	1	Both	both	DT
cord-017337-vq3edhxn	39	2	can	can	MD
cord-017337-vq3edhxn	39	3	develop	develop	VB
cord-017337-vq3edhxn	39	4	in	in	IN
cord-017337-vq3edhxn	39	5	(	(	-LRB-
cord-017337-vq3edhxn	39	6	almost	almost	RB
cord-017337-vq3edhxn	39	7	)	)	-RRB-
cord-017337-vq3edhxn	39	8	any	any	DT
cord-017337-vq3edhxn	39	9	organ	organ	NN
cord-017337-vq3edhxn	39	10	,	,	,
cord-017337-vq3edhxn	39	11	and	and	CC
cord-017337-vq3edhxn	39	12	both	both	DT
cord-017337-vq3edhxn	39	13	frequently	frequently	RB
cord-017337-vq3edhxn	39	14	require	require	VBP
cord-017337-vq3edhxn	39	15	surgical	surgical	JJ
cord-017337-vq3edhxn	39	16	and	and	CC
cord-017337-vq3edhxn	39	17	medical	medical	JJ
cord-017337-vq3edhxn	39	18	therapies	therapy	NNS
cord-017337-vq3edhxn	39	19	.	.	.
cord-017337-vq3edhxn	40	1	Treatments	treatment	NNS
cord-017337-vq3edhxn	40	2	for	for	IN
cord-017337-vq3edhxn	40	3	both	both	DT
cord-017337-vq3edhxn	40	4	are	be	VBP
cord-017337-vq3edhxn	40	5	expensive	expensive	JJ
cord-017337-vq3edhxn	40	6	and	and	CC
cord-017337-vq3edhxn	40	7	often	often	RB
cord-017337-vq3edhxn	40	8	involve	involve	VBP
cord-017337-vq3edhxn	40	9	several	several	JJ
cord-017337-vq3edhxn	40	10	pharmacological	pharmacological	JJ
cord-017337-vq3edhxn	40	11	agents	agent	NNS
cord-017337-vq3edhxn	40	12	.	.	.
cord-017337-vq3edhxn	41	1	Finally	finally	RB
cord-017337-vq3edhxn	41	2	,	,	,
cord-017337-vq3edhxn	41	3	when	when	WRB
cord-017337-vq3edhxn	41	4	treatment	treatment	NN
cord-017337-vq3edhxn	41	5	is	be	VBZ
cord-017337-vq3edhxn	41	6	successful	successful	JJ
cord-017337-vq3edhxn	41	7	,	,	,
cord-017337-vq3edhxn	41	8	it	-PRON-	PRP
cord-017337-vq3edhxn	41	9	is	be	VBZ
cord-017337-vq3edhxn	41	10	associated	associate	VBN
cord-017337-vq3edhxn	41	11	with	with	IN
cord-017337-vq3edhxn	41	12	slow	slow	JJ
cord-017337-vq3edhxn	41	13	step	step	NN
cord-017337-vq3edhxn	41	14	-	-	HYPH
cord-017337-vq3edhxn	41	15	by	by	IN
cord-017337-vq3edhxn	41	16	-	-	HYPH
cord-017337-vq3edhxn	41	17	step	step	NN
cord-017337-vq3edhxn	41	18	improvement	improvement	NN
cord-017337-vq3edhxn	41	19	.	.	.
cord-017337-vq3edhxn	42	1	Size	size	NN
cord-017337-vq3edhxn	42	2	and/or	and/or	CC
cord-017337-vq3edhxn	42	3	extent	extent	NN
cord-017337-vq3edhxn	42	4	of	of	IN
cord-017337-vq3edhxn	42	5	the	the	DT
cord-017337-vq3edhxn	42	6	primary	primary	JJ
cord-017337-vq3edhxn	42	7	tumor	tumor	NN
cord-017337-vq3edhxn	42	8	Regional	regional	JJ
cord-017337-vq3edhxn	42	9	lymph	lymph	NN
cord-017337-vq3edhxn	42	10	nodes	node	NNS
cord-017337-vq3edhxn	43	1	(	(	-LRB-
cord-017337-vq3edhxn	43	2	N	n	NN
cord-017337-vq3edhxn	43	3	)	)	-RRB-
cord-017337-vq3edhxn	44	1	Nx	Nx	NNP
cord-017337-vq3edhxn	44	2	Regional	regional	JJ
cord-017337-vq3edhxn	44	3	lymph	lymph	NN
cord-017337-vq3edhxn	44	4	nodes	node	NNS
cord-017337-vq3edhxn	44	5	not	not	RB
cord-017337-vq3edhxn	44	6	evaluated	evaluate	VBN
cord-017337-vq3edhxn	44	7	N0	N0	NNP
cord-017337-vq3edhxn	44	8	No	no	DT
cord-017337-vq3edhxn	44	9	regional	regional	JJ
cord-017337-vq3edhxn	44	10	lymph	lymph	NN
cord-017337-vq3edhxn	44	11	node	node	NN
cord-017337-vq3edhxn	44	12	involvement	involvement	NN
cord-017337-vq3edhxn	44	13	N1	N1	NNP
cord-017337-vq3edhxn	44	14	,	,	,
cord-017337-vq3edhxn	44	15	2	2	CD
cord-017337-vq3edhxn	44	16	,	,	,
cord-017337-vq3edhxn	44	17	3	3	CD
cord-017337-vq3edhxn	44	18	Number	number	NN
cord-017337-vq3edhxn	44	19	and	and	CC
cord-017337-vq3edhxn	44	20	extent	extent	NN
cord-017337-vq3edhxn	44	21	of	of	IN
cord-017337-vq3edhxn	44	22	regional	regional	JJ
cord-017337-vq3edhxn	44	23	lymph	lymph	NN
cord-017337-vq3edhxn	44	24	node	node	NN
cord-017337-vq3edhxn	44	25	involvement	involvement	NN
cord-017337-vq3edhxn	45	1	These	these	DT
cord-017337-vq3edhxn	45	2	similarities	similarity	NNS
cord-017337-vq3edhxn	45	3	between	between	IN
cord-017337-vq3edhxn	45	4	sepsis	sepsis	NN
cord-017337-vq3edhxn	45	5	and	and	CC
cord-017337-vq3edhxn	45	6	cancer	cancer	NN
cord-017337-vq3edhxn	45	7	led	lead	VBD
cord-017337-vq3edhxn	45	8	to	to	IN
cord-017337-vq3edhxn	45	9	the	the	DT
cord-017337-vq3edhxn	45	10	suggestion	suggestion	NN
cord-017337-vq3edhxn	45	11	that	that	IN
cord-017337-vq3edhxn	45	12	a	a	DT
cord-017337-vq3edhxn	45	13	disease	disease	NN
cord-017337-vq3edhxn	45	14	stratifi	stratifi	NNP
cord-017337-vq3edhxn	45	15	cation	cation	NN
cord-017337-vq3edhxn	45	16	system	system	NN
cord-017337-vq3edhxn	45	17	,	,	,
cord-017337-vq3edhxn	45	18	similar	similar	JJ
cord-017337-vq3edhxn	45	19	to	to	IN
cord-017337-vq3edhxn	45	20	the	the	DT
cord-017337-vq3edhxn	45	21	TNM	TNM	NNP
cord-017337-vq3edhxn	45	22	system	system	NN
cord-017337-vq3edhxn	45	23	for	for	IN
cord-017337-vq3edhxn	45	24	cancer	cancer	NN
cord-017337-vq3edhxn	45	25	,	,	,
cord-017337-vq3edhxn	45	26	could	could	MD
cord-017337-vq3edhxn	45	27	be	be	VB
cord-017337-vq3edhxn	45	28	developed	develop	VBN
cord-017337-vq3edhxn	45	29	for	for	IN
cord-017337-vq3edhxn	45	30	sepsis	sepsis	NN
cord-017337-vq3edhxn	45	31	[	[	-LRB-
cord-017337-vq3edhxn	45	32	5	5	CD
cord-017337-vq3edhxn	45	33	]	]	-RRB-
cord-017337-vq3edhxn	45	34	.	.	.
cord-017337-vq3edhxn	46	1	The	the	DT
cord-017337-vq3edhxn	46	2	PIRO	PIRO	NNP
cord-017337-vq3edhxn	46	3	system	system	NN
cord-017337-vq3edhxn	46	4	for	for	IN
cord-017337-vq3edhxn	46	5	the	the	DT
cord-017337-vq3edhxn	46	6	grading	grading	NN
cord-017337-vq3edhxn	46	7	of	of	IN
cord-017337-vq3edhxn	46	8	sepsis	sepsis	NN
cord-017337-vq3edhxn	46	9	uses	use	VBZ
cord-017337-vq3edhxn	46	10	clinical	clinical	JJ
cord-017337-vq3edhxn	46	11	and	and	CC
cord-017337-vq3edhxn	46	12	laboratory	laboratory	NN
cord-017337-vq3edhxn	46	13	parameters	parameter	NNS
cord-017337-vq3edhxn	46	14	to	to	TO
cord-017337-vq3edhxn	46	15	aid	aid	VB
cord-017337-vq3edhxn	46	16	diagnosis	diagnosis	NN
cord-017337-vq3edhxn	46	17	and	and	CC
cord-017337-vq3edhxn	46	18	patient	patient	JJ
cord-017337-vq3edhxn	46	19	classifi	classifi	NNP
cord-017337-vq3edhxn	46	20	cation	cation	NNP
cord-017337-vq3edhxn	46	21	,	,	,
cord-017337-vq3edhxn	46	22	with	with	IN
cord-017337-vq3edhxn	46	23	each	each	DT
cord-017337-vq3edhxn	46	24	element	element	NN
cord-017337-vq3edhxn	46	25	being	be	VBG
cord-017337-vq3edhxn	46	26	divided	divide	VBN
cord-017337-vq3edhxn	46	27	according	accord	VBG
cord-017337-vq3edhxn	46	28	to	to	IN
cord-017337-vq3edhxn	46	29	the	the	DT
cord-017337-vq3edhxn	46	30	degree	degree	NN
cord-017337-vq3edhxn	46	31	of	of	IN
cord-017337-vq3edhxn	46	32	involvement	involvement	NN
cord-017337-vq3edhxn	46	33	(	(	-LRB-
cord-017337-vq3edhxn	46	34	e.g.	e.g.	RB
cord-017337-vq3edhxn	46	35	,	,	,
cord-017337-vq3edhxn	46	36	infection	infection	NN
cord-017337-vq3edhxn	47	1	can	can	MD
cord-017337-vq3edhxn	47	2	be	be	VB
cord-017337-vq3edhxn	47	3	classifi	classifi	NNP
cord-017337-vq3edhxn	47	4	ed	ed	NN
cord-017337-vq3edhxn	47	5	as	as	IN
cord-017337-vq3edhxn	47	6	localized	localize	VBN
cord-017337-vq3edhxn	47	7	,	,	,
cord-017337-vq3edhxn	47	8	extended	extended	JJ
cord-017337-vq3edhxn	47	9	,	,	,
cord-017337-vq3edhxn	47	10	or	or	CC
cord-017337-vq3edhxn	47	11	generalized	generalize	VBN
cord-017337-vq3edhxn	47	12	;	;	:
cord-017337-vq3edhxn	47	13	immune	immune	JJ
cord-017337-vq3edhxn	47	14	response	response	NN
cord-017337-vq3edhxn	47	15	can	can	MD
cord-017337-vq3edhxn	47	16	be	be	VB
cord-017337-vq3edhxn	47	17	classifi	classifi	NNP
cord-017337-vq3edhxn	47	18	ed	ed	NN
cord-017337-vq3edhxn	47	19	as	as	IN
cord-017337-vq3edhxn	47	20	limited	limited	JJ
cord-017337-vq3edhxn	47	21	,	,	,
cord-017337-vq3edhxn	47	22	extensive	extensive	JJ
cord-017337-vq3edhxn	47	23	,	,	,
cord-017337-vq3edhxn	47	24	or	or	CC
cord-017337-vq3edhxn	47	25	excessive	excessive	JJ
cord-017337-vq3edhxn	47	26	;	;	:
cord-017337-vq3edhxn	47	27	organ	organ	NN
cord-017337-vq3edhxn	47	28	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	47	29	can	can	MD
cord-017337-vq3edhxn	47	30	be	be	VB
cord-017337-vq3edhxn	47	31	classifi	classifi	NNP
cord-017337-vq3edhxn	47	32	ed	ed	NNP
cord-017337-vq3edhxn	47	33	as	as	RB
cord-017337-vq3edhxn	47	34	mild	mild	JJ
cord-017337-vq3edhxn	47	35	,	,	,
cord-017337-vq3edhxn	47	36	moderate	moderate	JJ
cord-017337-vq3edhxn	47	37	,	,	,
cord-017337-vq3edhxn	47	38	severe	severe	JJ
cord-017337-vq3edhxn	47	39	)	)	-RRB-
cord-017337-vq3edhxn	47	40	.	.	.
cord-017337-vq3edhxn	48	1	As	as	IN
cord-017337-vq3edhxn	48	2	with	with	IN
cord-017337-vq3edhxn	48	3	the	the	DT
cord-017337-vq3edhxn	48	4	TNM	TNM	NNP
cord-017337-vq3edhxn	48	5	system	system	NN
cord-017337-vq3edhxn	48	6	,	,	,
cord-017337-vq3edhxn	48	7	it	-PRON-	PRP
cord-017337-vq3edhxn	48	8	has	have	VBZ
cord-017337-vq3edhxn	48	9	been	be	VBN
cord-017337-vq3edhxn	48	10	proposed	propose	VBN
cord-017337-vq3edhxn	48	11	that	that	IN
cord-017337-vq3edhxn	48	12	points	point	NNS
cord-017337-vq3edhxn	48	13	could	could	MD
cord-017337-vq3edhxn	48	14	be	be	VB
cord-017337-vq3edhxn	48	15	allocated	allocate	VBN
cord-017337-vq3edhxn	48	16	such	such	JJ
cord-017337-vq3edhxn	48	17	that	that	IN
cord-017337-vq3edhxn	48	18	a	a	DT
cord-017337-vq3edhxn	48	19	patient	patient	NN
cord-017337-vq3edhxn	48	20	with	with	IN
cord-017337-vq3edhxn	48	21	sepsis	sepsis	NN
cord-017337-vq3edhxn	48	22	could	could	MD
cord-017337-vq3edhxn	48	23	,	,	,
cord-017337-vq3edhxn	48	24	for	for	IN
cord-017337-vq3edhxn	48	25	example	example	NN
cord-017337-vq3edhxn	48	26	,	,	,
cord-017337-vq3edhxn	48	27	be	be	VB
cord-017337-vq3edhxn	48	28	staged	stage	VBN
cord-017337-vq3edhxn	48	29	as	as	IN
cord-017337-vq3edhxn	48	30	P	p	NN
cord-017337-vq3edhxn	48	31	1	1	CD
cord-017337-vq3edhxn	48	32	I	i	NN
cord-017337-vq3edhxn	48	33	2	2	CD
cord-017337-vq3edhxn	48	34	R	r	NN
cord-017337-vq3edhxn	48	35	1	1	CD
cord-017337-vq3edhxn	48	36	O	o	NN
cord-017337-vq3edhxn	48	37	0	0	CD
cord-017337-vq3edhxn	48	38	[	[	-LRB-
cord-017337-vq3edhxn	48	39	6	6	CD
cord-017337-vq3edhxn	48	40	]	]	-RRB-
cord-017337-vq3edhxn	48	41	,	,	,
cord-017337-vq3edhxn	48	42	depending	depend	VBG
cord-017337-vq3edhxn	48	43	on	on	IN
cord-017337-vq3edhxn	48	44	the	the	DT
cord-017337-vq3edhxn	48	45	features	feature	NNS
cord-017337-vq3edhxn	48	46	present	present	JJ
cord-017337-vq3edhxn	48	47	for	for	IN
cord-017337-vq3edhxn	48	48	each	each	DT
cord-017337-vq3edhxn	48	49	of	of	IN
cord-017337-vq3edhxn	48	50	the	the	DT
cord-017337-vq3edhxn	48	51	four	four	CD
cord-017337-vq3edhxn	48	52	PIRO	PIRO	NNP
cord-017337-vq3edhxn	48	53	components	component	NNS
cord-017337-vq3edhxn	48	54	.	.	.
cord-017337-vq3edhxn	49	1	All	all	DT
cord-017337-vq3edhxn	49	2	aspects	aspect	NNS
cord-017337-vq3edhxn	49	3	of	of	IN
cord-017337-vq3edhxn	49	4	the	the	DT
cord-017337-vq3edhxn	49	5	four	four	CD
cord-017337-vq3edhxn	49	6	components	component	NNS
cord-017337-vq3edhxn	49	7	of	of	IN
cord-017337-vq3edhxn	49	8	the	the	DT
cord-017337-vq3edhxn	49	9	PIRO	PIRO	NNP
cord-017337-vq3edhxn	49	10	system	system	NN
cord-017337-vq3edhxn	49	11	impact	impact	NN
cord-017337-vq3edhxn	49	12	on	on	IN
cord-017337-vq3edhxn	49	13	outcome	outcome	NN
cord-017337-vq3edhxn	49	14	and	and	CC
cord-017337-vq3edhxn	49	15	can	can	MD
cord-017337-vq3edhxn	49	16	infl	infl	VB
cord-017337-vq3edhxn	49	17	uence	uence	NN
cord-017337-vq3edhxn	49	18	therapeutic	therapeutic	JJ
cord-017337-vq3edhxn	49	19	choices	choice	NNS
cord-017337-vq3edhxn	49	20	.	.	.
cord-017337-vq3edhxn	50	1	As	as	IN
cord-017337-vq3edhxn	50	2	the	the	DT
cord-017337-vq3edhxn	50	3	TNM	TNM	NNP
cord-017337-vq3edhxn	50	4	system	system	NN
cord-017337-vq3edhxn	50	5	is	be	VBZ
cord-017337-vq3edhxn	50	6	divided	divide	VBN
cord-017337-vq3edhxn	50	7	into	into	IN
cord-017337-vq3edhxn	50	8	clinical	clinical	JJ
cord-017337-vq3edhxn	50	9	(	(	-LRB-
cord-017337-vq3edhxn	50	10	cTcNcM	ctcncm	UH
cord-017337-vq3edhxn	50	11	)	)	-RRB-
cord-017337-vq3edhxn	50	12	and	and	CC
cord-017337-vq3edhxn	50	13	pathological	pathological	JJ
cord-017337-vq3edhxn	50	14	(	(	-LRB-
cord-017337-vq3edhxn	50	15	pTpNpM	pTpNpM	NNP
cord-017337-vq3edhxn	50	16	)	)	-RRB-
cord-017337-vq3edhxn	50	17	classifi	classifi	NN
cord-017337-vq3edhxn	50	18	cations	cation	NNS
cord-017337-vq3edhxn	50	19	,	,	,
cord-017337-vq3edhxn	50	20	so	so	IN
cord-017337-vq3edhxn	50	21	each	each	DT
cord-017337-vq3edhxn	50	22	component	component	NN
cord-017337-vq3edhxn	50	23	of	of	IN
cord-017337-vq3edhxn	50	24	PIRO	PIRO	NNP
cord-017337-vq3edhxn	50	25	can	can	MD
cord-017337-vq3edhxn	50	26	be	be	VB
cord-017337-vq3edhxn	50	27	considered	consider	VBN
cord-017337-vq3edhxn	50	28	to	to	TO
cord-017337-vq3edhxn	50	29	have	have	VB
cord-017337-vq3edhxn	50	30	potentially	potentially	RB
cord-017337-vq3edhxn	50	31	relevant	relevant	JJ
cord-017337-vq3edhxn	50	32	clinical	clinical	JJ
cord-017337-vq3edhxn	50	33	and	and	CC
cord-017337-vq3edhxn	50	34	laboratory	laboratory	NN
cord-017337-vq3edhxn	50	35	variables	variable	NNS
cord-017337-vq3edhxn	50	36	(	(	-LRB-
cord-017337-vq3edhxn	50	37	Table	table	NN
cord-017337-vq3edhxn	50	38	2	2	CD
cord-017337-vq3edhxn	50	39	)	)	-RRB-
cord-017337-vq3edhxn	50	40	.	.	.
cord-017337-vq3edhxn	51	1	Predisposition	predisposition	NN
cord-017337-vq3edhxn	51	2	can	can	MD
cord-017337-vq3edhxn	51	3	include	include	VB
cord-017337-vq3edhxn	51	4	multiple	multiple	JJ
cord-017337-vq3edhxn	51	5	factors	factor	NNS
cord-017337-vq3edhxn	51	6	such	such	JJ
cord-017337-vq3edhxn	51	7	as	as	IN
cord-017337-vq3edhxn	51	8	age	age	NN
cord-017337-vq3edhxn	51	9	,	,	,
cord-017337-vq3edhxn	51	10	sex	sex	NN
cord-017337-vq3edhxn	51	11	,	,	,
cord-017337-vq3edhxn	51	12	presence	presence	NN
cord-017337-vq3edhxn	51	13	of	of	IN
cord-017337-vq3edhxn	51	14	certain	certain	JJ
cord-017337-vq3edhxn	51	15	premorbid	premorbid	NN
cord-017337-vq3edhxn	51	16	diseases	disease	NNS
cord-017337-vq3edhxn	51	17	,	,	,
cord-017337-vq3edhxn	51	18	prolonged	prolong	VBN
cord-017337-vq3edhxn	51	19	immunosuppressant	immunosuppressant	JJ
cord-017337-vq3edhxn	51	20	or	or	CC
cord-017337-vq3edhxn	51	21	antimicrobial	antimicrobial	JJ
cord-017337-vq3edhxn	51	22	medication	medication	NN
cord-017337-vq3edhxn	51	23	,	,	,
cord-017337-vq3edhxn	51	24	even	even	RB
cord-017337-vq3edhxn	51	25	cultural	cultural	JJ
cord-017337-vq3edhxn	51	26	and	and	CC
cord-017337-vq3edhxn	51	27	religious	religious	JJ
cord-017337-vq3edhxn	51	28	beliefs	belief	NNS
cord-017337-vq3edhxn	51	29	[	[	-LRB-
cord-017337-vq3edhxn	51	30	8	8	CD
cord-017337-vq3edhxn	51	31	]	]	-RRB-
cord-017337-vq3edhxn	51	32	.	.	.
cord-017337-vq3edhxn	52	1	All	all	PDT
cord-017337-vq3edhxn	52	2	these	these	DT
cord-017337-vq3edhxn	52	3	factors	factor	NNS
cord-017337-vq3edhxn	52	4	individually	individually	RB
cord-017337-vq3edhxn	52	5	and	and	CC
cord-017337-vq3edhxn	52	6	collectively	collectively	RB
cord-017337-vq3edhxn	52	7	can	can	MD
cord-017337-vq3edhxn	52	8	impact	impact	VB
cord-017337-vq3edhxn	52	9	on	on	IN
cord-017337-vq3edhxn	52	10	outcome	outcome	NN
cord-017337-vq3edhxn	52	11	,	,	,
cord-017337-vq3edhxn	52	12	modifying	modify	VBG
cord-017337-vq3edhxn	52	13	both	both	CC
cord-017337-vq3edhxn	52	14	the	the	DT
cord-017337-vq3edhxn	52	15	disease	disease	NN
cord-017337-vq3edhxn	52	16	process	process	NN
cord-017337-vq3edhxn	52	17	and	and	CC
cord-017337-vq3edhxn	52	18	the	the	DT
cord-017337-vq3edhxn	52	19	approach	approach	NN
cord-017337-vq3edhxn	52	20	to	to	IN
cord-017337-vq3edhxn	52	21	therapy	therapy	NN
cord-017337-vq3edhxn	52	22	.	.	.
cord-017337-vq3edhxn	53	1	Recent	recent	JJ
cord-017337-vq3edhxn	53	2	advances	advance	NNS
cord-017337-vq3edhxn	53	3	in	in	IN
cord-017337-vq3edhxn	53	4	genetic	genetic	JJ
cord-017337-vq3edhxn	53	5	techniques	technique	NNS
cord-017337-vq3edhxn	53	6	have	have	VBP
cord-017337-vq3edhxn	53	7	enabled	enable	VBN
cord-017337-vq3edhxn	53	8	several	several	JJ
cord-017337-vq3edhxn	53	9	factors	factor	NNS
cord-017337-vq3edhxn	53	10	associated	associate	VBN
cord-017337-vq3edhxn	53	11	with	with	IN
cord-017337-vq3edhxn	53	12	an	an	DT
cord-017337-vq3edhxn	53	13	increased	increase	VBN
cord-017337-vq3edhxn	53	14	risk	risk	NN
cord-017337-vq3edhxn	53	15	of	of	IN
cord-017337-vq3edhxn	53	16	infection	infection	NN
cord-017337-vq3edhxn	53	17	and	and	CC
cord-017337-vq3edhxn	53	18	of	of	IN
cord-017337-vq3edhxn	53	19	mortality	mortality	NN
cord-017337-vq3edhxn	53	20	from	from	IN
cord-017337-vq3edhxn	53	21	sepsis	sepsis	NN
cord-017337-vq3edhxn	53	22	to	to	TO
cord-017337-vq3edhxn	53	23	be	be	VB
cord-017337-vq3edhxn	53	24	identifi	identifi	VBN
cord-017337-vq3edhxn	53	25	ed	ed	NNP
cord-017337-vq3edhxn	53	26	.	.	.
cord-017337-vq3edhxn	54	1	Single	single	JJ
cord-017337-vq3edhxn	54	2	nucleotide	nucleotide	JJ
cord-017337-vq3edhxn	54	3	polymorphisms	polymorphism	NNS
cord-017337-vq3edhxn	54	4	,	,	,
cord-017337-vq3edhxn	54	5	microsatellites	microsatellite	NNS
cord-017337-vq3edhxn	54	6	,	,	,
cord-017337-vq3edhxn	54	7	insertion	insertion	NN
cord-017337-vq3edhxn	54	8	and	and	CC
cord-017337-vq3edhxn	54	9	deletion	deletion	NN
cord-017337-vq3edhxn	54	10	polymorphisms	polymorphism	NNS
cord-017337-vq3edhxn	54	11	are	be	VBP
cord-017337-vq3edhxn	54	12	all	all	DT
cord-017337-vq3edhxn	54	13	forms	form	NNS
cord-017337-vq3edhxn	54	14	of	of	IN
cord-017337-vq3edhxn	54	15	genetic	genetic	JJ
cord-017337-vq3edhxn	54	16	variation	variation	NN
cord-017337-vq3edhxn	54	17	that	that	WDT
cord-017337-vq3edhxn	54	18	can	can	MD
cord-017337-vq3edhxn	54	19	characterize	characterize	VB
cord-017337-vq3edhxn	54	20	an	an	DT
cord-017337-vq3edhxn	54	21	individual	individual	NN
cord-017337-vq3edhxn	54	22	's	's	POS
cord-017337-vq3edhxn	54	23	risk	risk	NN
cord-017337-vq3edhxn	54	24	for	for	IN
cord-017337-vq3edhxn	54	25	sepsis	sepsis	NN
cord-017337-vq3edhxn	54	26	,	,	,
cord-017337-vq3edhxn	54	27	organ	organ	NN
cord-017337-vq3edhxn	54	28	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	54	29	,	,	,
cord-017337-vq3edhxn	54	30	or	or	CC
cord-017337-vq3edhxn	54	31	death	death	NN
cord-017337-vq3edhxn	54	32	[	[	-LRB-
cord-017337-vq3edhxn	54	33	9	9	CD
cord-017337-vq3edhxn	54	34	]	]	-RRB-
cord-017337-vq3edhxn	54	35	.	.	.
cord-017337-vq3edhxn	55	1	Most	Most	JJS
cord-017337-vq3edhxn	55	2	genetic	genetic	JJ
cord-017337-vq3edhxn	55	3	traits	trait	NNS
cord-017337-vq3edhxn	55	4	associated	associate	VBN
cord-017337-vq3edhxn	55	5	with	with	IN
cord-017337-vq3edhxn	55	6	severe	severe	JJ
cord-017337-vq3edhxn	55	7	infection	infection	NN
cord-017337-vq3edhxn	55	8	are	be	VBP
cord-017337-vq3edhxn	55	9	associated	associate	VBN
cord-017337-vq3edhxn	55	10	with	with	IN
cord-017337-vq3edhxn	55	11	defects	defect	NNS
cord-017337-vq3edhxn	55	12	in	in	IN
cord-017337-vq3edhxn	55	13	innate	innate	JJ
cord-017337-vq3edhxn	55	14	immune	immune	JJ
cord-017337-vq3edhxn	55	15	responses	response	NNS
cord-017337-vq3edhxn	55	16	.	.	.
cord-017337-vq3edhxn	56	1	For	for	IN
cord-017337-vq3edhxn	56	2	example	example	NN
cord-017337-vq3edhxn	56	3	,	,	,
cord-017337-vq3edhxn	56	4	a	a	DT
cord-017337-vq3edhxn	56	5	polymorphism	polymorphism	NN
cord-017337-vq3edhxn	56	6	of	of	IN
cord-017337-vq3edhxn	56	7	the	the	DT
cord-017337-vq3edhxn	56	8	tumor	tumor	NN
cord-017337-vq3edhxn	56	9	necrosis	necrosis	NN
cord-017337-vq3edhxn	56	10	factor	factor	NN
cord-017337-vq3edhxn	56	11	(	(	-LRB-
cord-017337-vq3edhxn	56	12	TNF)-α	TNF)-α	NNP
cord-017337-vq3edhxn	56	13	gene	gene	NN
cord-017337-vq3edhxn	56	14	,	,	,
cord-017337-vq3edhxn	56	15	the	the	DT
cord-017337-vq3edhxn	56	16	TNF-2	TNF-2	NNP
cord-017337-vq3edhxn	56	17	allele	allele	NN
cord-017337-vq3edhxn	56	18	,	,	,
cord-017337-vq3edhxn	56	19	is	be	VBZ
cord-017337-vq3edhxn	56	20	associated	associate	VBN
cord-017337-vq3edhxn	56	21	with	with	IN
cord-017337-vq3edhxn	56	22	increased	increase	VBN
cord-017337-vq3edhxn	56	23	serum	serum	NN
cord-017337-vq3edhxn	56	24	levels	level	NNS
cord-017337-vq3edhxn	56	25	of	of	IN
cord-017337-vq3edhxn	56	26	TNF	TNF	NNP
cord-017337-vq3edhxn	56	27	and	and	CC
cord-017337-vq3edhxn	56	28	a	a	DT
cord-017337-vq3edhxn	56	29	greater	great	JJR
cord-017337-vq3edhxn	56	30	risk	risk	NN
cord-017337-vq3edhxn	56	31	of	of	IN
cord-017337-vq3edhxn	56	32	mortality	mortality	NN
cord-017337-vq3edhxn	56	33	from	from	IN
cord-017337-vq3edhxn	56	34	septic	septic	JJ
cord-017337-vq3edhxn	56	35	shock	shock	NN
cord-017337-vq3edhxn	56	36	[	[	-LRB-
cord-017337-vq3edhxn	56	37	10	10	CD
cord-017337-vq3edhxn	56	38	]	]	-RRB-
cord-017337-vq3edhxn	56	39	.	.	.
cord-017337-vq3edhxn	57	1	A	a	DT
cord-017337-vq3edhxn	57	2	polymorphism	polymorphism	NN
cord-017337-vq3edhxn	57	3	within	within	IN
cord-017337-vq3edhxn	57	4	intron	intron	NN
cord-017337-vq3edhxn	57	5	2	2	CD
cord-017337-vq3edhxn	57	6	of	of	IN
cord-017337-vq3edhxn	57	7	the	the	DT
cord-017337-vq3edhxn	57	8	interleukin-1	interleukin-1	NNP
cord-017337-vq3edhxn	57	9	receptor	receptor	NN
cord-017337-vq3edhxn	57	10	antagonist	antagonist	NN
cord-017337-vq3edhxn	57	11	(	(	-LRB-
cord-017337-vq3edhxn	57	12	IL-1ra	IL-1ra	NNP
cord-017337-vq3edhxn	57	13	)	)	-RRB-
cord-017337-vq3edhxn	57	14	gene	gene	NN
cord-017337-vq3edhxn	57	15	(	(	-LRB-
cord-017337-vq3edhxn	57	16	IL-1RN	il-1rn	NN
cord-017337-vq3edhxn	57	17	*	*	NFP
cord-017337-vq3edhxn	57	18	2	2	LS
cord-017337-vq3edhxn	57	19	)	)	-RRB-
cord-017337-vq3edhxn	57	20	has	have	VBZ
cord-017337-vq3edhxn	57	21	been	be	VBN
cord-017337-vq3edhxn	57	22	associated	associate	VBN
cord-017337-vq3edhxn	57	23	with	with	IN
cord-017337-vq3edhxn	57	24	reduced	reduce	VBN
cord-017337-vq3edhxn	57	25	IL-1ra	IL-1ra	NNP
cord-017337-vq3edhxn	57	26	production	production	NN
cord-017337-vq3edhxn	57	27	and	and	CC
cord-017337-vq3edhxn	57	28	increased	increase	VBN
cord-017337-vq3edhxn	57	29	mortality	mortality	NN
cord-017337-vq3edhxn	57	30	rates	rate	NNS
cord-017337-vq3edhxn	57	31	[	[	-LRB-
cord-017337-vq3edhxn	57	32	11	11	CD
cord-017337-vq3edhxn	57	33	]	]	-RRB-
cord-017337-vq3edhxn	57	34	.	.	.
cord-017337-vq3edhxn	58	1	Recently	recently	RB
cord-017337-vq3edhxn	58	2	,	,	,
cord-017337-vq3edhxn	58	3	polymorphisms	polymorphism	NNS
cord-017337-vq3edhxn	58	4	in	in	IN
cord-017337-vq3edhxn	58	5	the	the	DT
cord-017337-vq3edhxn	58	6	Toll	Toll	NNP
cord-017337-vq3edhxn	58	7	-	-	HYPH
cord-017337-vq3edhxn	58	8	like	like	JJ
cord-017337-vq3edhxn	58	9	receptor	receptor	NN
cord-017337-vq3edhxn	58	10	1	1	CD
cord-017337-vq3edhxn	58	11	gene	gene	NN
cord-017337-vq3edhxn	58	12	were	be	VBD
cord-017337-vq3edhxn	58	13	reported	report	VBN
cord-017337-vq3edhxn	58	14	to	to	TO
cord-017337-vq3edhxn	58	15	be	be	VB
cord-017337-vq3edhxn	58	16	associated	associate	VBN
cord-017337-vq3edhxn	58	17	with	with	IN
cord-017337-vq3edhxn	58	18	increased	increase	VBN
cord-017337-vq3edhxn	58	19	susceptibility	susceptibility	NN
cord-017337-vq3edhxn	58	20	to	to	IN
cord-017337-vq3edhxn	58	21	organ	organ	NN
cord-017337-vq3edhxn	58	22	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	58	23	,	,	,
cord-017337-vq3edhxn	58	24	death	death	NN
cord-017337-vq3edhxn	58	25	,	,	,
cord-017337-vq3edhxn	58	26	and	and	CC
cord-017337-vq3edhxn	58	27	Gram	gram	NN
cord-017337-vq3edhxn	58	28	-	-	HYPH
cord-017337-vq3edhxn	58	29	positive	positive	JJ
cord-017337-vq3edhxn	58	30	infection	infection	NN
cord-017337-vq3edhxn	58	31	in	in	IN
cord-017337-vq3edhxn	58	32	sepsis	sepsis	NN
cord-017337-vq3edhxn	58	33	[	[	-LRB-
cord-017337-vq3edhxn	58	34	12	12	CD
cord-017337-vq3edhxn	58	35	]	]	-RRB-
cord-017337-vq3edhxn	58	36	.	.	.
cord-017337-vq3edhxn	59	1	Sex	sex	NN
cord-017337-vq3edhxn	59	2	differences	difference	NNS
cord-017337-vq3edhxn	59	3	are	be	VBP
cord-017337-vq3edhxn	59	4	another	another	DT
cord-017337-vq3edhxn	59	5	area	area	NN
cord-017337-vq3edhxn	59	6	of	of	IN
cord-017337-vq3edhxn	59	7	interest	interest	NN
cord-017337-vq3edhxn	59	8	with	with	IN
cord-017337-vq3edhxn	59	9	several	several	JJ
cord-017337-vq3edhxn	59	10	studies	study	NNS
cord-017337-vq3edhxn	59	11	reporting	report	VBG
cord-017337-vq3edhxn	59	12	that	that	IN
cord-017337-vq3edhxn	59	13	women	woman	NNS
cord-017337-vq3edhxn	59	14	are	be	VBP
cord-017337-vq3edhxn	59	15	less	less	RBR
cord-017337-vq3edhxn	59	16	likely	likely	JJ
cord-017337-vq3edhxn	59	17	to	to	TO
cord-017337-vq3edhxn	59	18	develop	develop	VB
cord-017337-vq3edhxn	59	19	sepsis	sepsis	NN
cord-017337-vq3edhxn	59	20	than	than	IN
cord-017337-vq3edhxn	59	21	men	man	NNS
cord-017337-vq3edhxn	59	22	[	[	-LRB-
cord-017337-vq3edhxn	59	23	13	13	CD
cord-017337-vq3edhxn	59	24	,	,	,
cord-017337-vq3edhxn	59	25	14	14	CD
cord-017337-vq3edhxn	59	26	]	]	-RRB-
cord-017337-vq3edhxn	59	27	.	.	.
cord-017337-vq3edhxn	60	1	However	however	RB
cord-017337-vq3edhxn	60	2	,	,	,
cord-017337-vq3edhxn	60	3	women	woman	NNS
cord-017337-vq3edhxn	60	4	who	who	WP
cord-017337-vq3edhxn	60	5	do	do	VBP
cord-017337-vq3edhxn	60	6	develop	develop	VB
cord-017337-vq3edhxn	60	7	sepsis	sepsis	NN
cord-017337-vq3edhxn	60	8	,	,	,
cord-017337-vq3edhxn	60	9	particularly	particularly	RB
cord-017337-vq3edhxn	60	10	older	old	JJR
cord-017337-vq3edhxn	60	11	women	woman	NNS
cord-017337-vq3edhxn	60	12	,	,	,
cord-017337-vq3edhxn	60	13	may	may	MD
cord-017337-vq3edhxn	60	14	have	have	VB
cord-017337-vq3edhxn	60	15	worse	bad	JJR
cord-017337-vq3edhxn	60	16	outcomes	outcome	NNS
cord-017337-vq3edhxn	60	17	than	than	IN
cord-017337-vq3edhxn	60	18	men	man	NNS
cord-017337-vq3edhxn	60	19	[	[	-LRB-
cord-017337-vq3edhxn	60	20	15	15	CD
cord-017337-vq3edhxn	60	21	,	,	,
cord-017337-vq3edhxn	60	22	16	16	CD
cord-017337-vq3edhxn	60	23	]	]	-RRB-
cord-017337-vq3edhxn	60	24	.	.	.
cord-017337-vq3edhxn	61	1	Studies	study	NNS
cord-017337-vq3edhxn	61	2	have	have	VBP
cord-017337-vq3edhxn	61	3	also	also	RB
cord-017337-vq3edhxn	61	4	suggested	suggest	VBN
cord-017337-vq3edhxn	61	5	racial	racial	JJ
cord-017337-vq3edhxn	61	6	differences	difference	NNS
cord-017337-vq3edhxn	61	7	in	in	IN
cord-017337-vq3edhxn	61	8	susceptibility	susceptibility	NN
cord-017337-vq3edhxn	61	9	to	to	IN
cord-017337-vq3edhxn	61	10	and	and	CC
cord-017337-vq3edhxn	61	11	outcomes	outcome	NNS
cord-017337-vq3edhxn	61	12	from	from	IN
cord-017337-vq3edhxn	61	13	sepsis	sepsis	NN
cord-017337-vq3edhxn	61	14	[	[	-LRB-
cord-017337-vq3edhxn	61	15	17	17	CD
cord-017337-vq3edhxn	61	16	]	]	-RRB-
cord-017337-vq3edhxn	61	17	,	,	,
cord-017337-vq3edhxn	61	18	and	and	CC
cord-017337-vq3edhxn	61	19	older	old	JJR
cord-017337-vq3edhxn	61	20	patients	patient	NNS
cord-017337-vq3edhxn	61	21	are	be	VBP
cord-017337-vq3edhxn	61	22	known	know	VBN
cord-017337-vq3edhxn	61	23	to	to	TO
cord-017337-vq3edhxn	61	24	be	be	VB
cord-017337-vq3edhxn	61	25	at	at	IN
cord-017337-vq3edhxn	61	26	an	an	DT
cord-017337-vq3edhxn	61	27	increased	increase	VBN
cord-017337-vq3edhxn	61	28	risk	risk	NN
cord-017337-vq3edhxn	61	29	of	of	IN
cord-017337-vq3edhxn	61	30	developing	develop	VBG
cord-017337-vq3edhxn	61	31	sepsis	sepsis	NN
cord-017337-vq3edhxn	61	32	and	and	CC
cord-017337-vq3edhxn	61	33	succumbing	succumb	VBG
cord-017337-vq3edhxn	61	34	to	to	IN
cord-017337-vq3edhxn	61	35	it	-PRON-	PRP
cord-017337-vq3edhxn	61	36	[	[	-LRB-
cord-017337-vq3edhxn	61	37	18	18	CD
cord-017337-vq3edhxn	61	38	]	]	-RRB-
cord-017337-vq3edhxn	61	39	.	.	.
cord-017337-vq3edhxn	62	1	Certain	certain	JJ
cord-017337-vq3edhxn	62	2	chronic	chronic	JJ
cord-017337-vq3edhxn	62	3	diseases	disease	NNS
cord-017337-vq3edhxn	62	4	,	,	,
cord-017337-vq3edhxn	62	5	such	such	JJ
cord-017337-vq3edhxn	62	6	as	as	IN
cord-017337-vq3edhxn	62	7	cirrhosis	cirrhosis	NN
cord-017337-vq3edhxn	62	8	,	,	,
cord-017337-vq3edhxn	62	9	diabetes	diabetes	NN
cord-017337-vq3edhxn	62	10	,	,	,
cord-017337-vq3edhxn	62	11	and	and	CC
cord-017337-vq3edhxn	62	12	chronic	chronic	JJ
cord-017337-vq3edhxn	62	13	obstructive	obstructive	JJ
cord-017337-vq3edhxn	62	14	pulmonary	pulmonary	JJ
cord-017337-vq3edhxn	62	15	disease	disease	NN
cord-017337-vq3edhxn	62	16	(	(	-LRB-
cord-017337-vq3edhxn	62	17	COPD	COPD	NNP
cord-017337-vq3edhxn	62	18	)	)	-RRB-
cord-017337-vq3edhxn	62	19	,	,	,
cord-017337-vq3edhxn	62	20	as	as	RB
cord-017337-vq3edhxn	62	21	well	well	RB
cord-017337-vq3edhxn	62	22	as	as	IN
cord-017337-vq3edhxn	62	23	chronic	chronic	JJ
cord-017337-vq3edhxn	62	24	use	use	NN
cord-017337-vq3edhxn	62	25	of	of	IN
cord-017337-vq3edhxn	62	26	immunosuppressant	immunosuppressant	JJ
cord-017337-vq3edhxn	62	27	medication	medication	NN
cord-017337-vq3edhxn	62	28	may	may	MD
cord-017337-vq3edhxn	62	29	also	also	RB
cord-017337-vq3edhxn	62	30	predispose	predispose	VB
cord-017337-vq3edhxn	62	31	to	to	TO
cord-017337-vq3edhxn	62	32	sepsis	sepsis	NN
cord-017337-vq3edhxn	62	33	and	and	CC
cord-017337-vq3edhxn	62	34	a	a	DT
cord-017337-vq3edhxn	62	35	worse	bad	JJR
cord-017337-vq3edhxn	62	36	outcome	outcome	NN
cord-017337-vq3edhxn	62	37	.	.	.
cord-017337-vq3edhxn	63	1	Moreover	moreover	RB
cord-017337-vq3edhxn	63	2	,	,	,
cord-017337-vq3edhxn	63	3	each	each	DT
cord-017337-vq3edhxn	63	4	factor	factor	NN
cord-017337-vq3edhxn	63	5	may	may	MD
cord-017337-vq3edhxn	63	6	have	have	VB
cord-017337-vq3edhxn	63	7	a	a	DT
cord-017337-vq3edhxn	63	8	different	different	JJ
cord-017337-vq3edhxn	63	9	impact	impact	NN
cord-017337-vq3edhxn	63	10	on	on	IN
cord-017337-vq3edhxn	63	11	the	the	DT
cord-017337-vq3edhxn	63	12	other	other	JJ
cord-017337-vq3edhxn	63	13	three	three	CD
cord-017337-vq3edhxn	63	14	PIRO	PIRO	NNP
cord-017337-vq3edhxn	63	15	components	component	NNS
cord-017337-vq3edhxn	63	16	[	[	-LRB-
cord-017337-vq3edhxn	63	17	5	5	CD
cord-017337-vq3edhxn	63	18	]	]	-RRB-
cord-017337-vq3edhxn	63	19	.	.	.
cord-017337-vq3edhxn	64	1	For	for	IN
cord-017337-vq3edhxn	64	2	example	example	NN
cord-017337-vq3edhxn	64	3	,	,	,
cord-017337-vq3edhxn	64	4	chronic	chronic	JJ
cord-017337-vq3edhxn	64	5	immunosuppression	immunosuppression	NN
cord-017337-vq3edhxn	64	6	may	may	MD
cord-017337-vq3edhxn	64	7	increase	increase	VB
cord-017337-vq3edhxn	64	8	a	a	DT
cord-017337-vq3edhxn	64	9	person	person	NN
cord-017337-vq3edhxn	64	10	's	's	POS
cord-017337-vq3edhxn	64	11	risk	risk	NN
cord-017337-vq3edhxn	64	12	of	of	IN
cord-017337-vq3edhxn	64	13	infection	infection	NN
cord-017337-vq3edhxn	64	14	,	,	,
cord-017337-vq3edhxn	64	15	but	but	CC
cord-017337-vq3edhxn	64	16	may	may	MD
cord-017337-vq3edhxn	64	17	decrease	decrease	VB
cord-017337-vq3edhxn	64	18	the	the	DT
cord-017337-vq3edhxn	64	19	magnitude	magnitude	NN
cord-017337-vq3edhxn	64	20	of	of	IN
cord-017337-vq3edhxn	64	21	that	that	DT
cord-017337-vq3edhxn	64	22	person	person	NN
cord-017337-vq3edhxn	64	23	's	's	POS
cord-017337-vq3edhxn	64	24	infl	infl	NNP
cord-017337-vq3edhxn	64	25	ammatory	ammatory	NNP
cord-017337-vq3edhxn	64	26	response	response	NN
cord-017337-vq3edhxn	64	27	.	.	.
cord-017337-vq3edhxn	65	1	Undoubtedly	undoubtedly	RB
cord-017337-vq3edhxn	65	2	these	these	DT
cord-017337-vq3edhxn	65	3	are	be	VBP
cord-017337-vq3edhxn	65	4	complex	complex	JJ
cord-017337-vq3edhxn	65	5	relationships	relationship	NNS
cord-017337-vq3edhxn	65	6	with	with	IN
cord-017337-vq3edhxn	65	7	multiple	multiple	JJ
cord-017337-vq3edhxn	65	8	confounding	confounding	JJ
cord-017337-vq3edhxn	65	9	factors	factor	NNS
cord-017337-vq3edhxn	65	10	and	and	CC
cord-017337-vq3edhxn	65	11	further	further	JJ
cord-017337-vq3edhxn	65	12	research	research	NN
cord-017337-vq3edhxn	65	13	is	be	VBZ
cord-017337-vq3edhxn	65	14	needed	need	VBN
cord-017337-vq3edhxn	65	15	to	to	TO
cord-017337-vq3edhxn	65	16	clearly	clearly	RB
cord-017337-vq3edhxn	65	17	defi	defi	NNP
cord-017337-vq3edhxn	65	18	ne	ne	NNP
cord-017337-vq3edhxn	65	19	which	which	WDT
cord-017337-vq3edhxn	65	20	factors	factor	NNS
cord-017337-vq3edhxn	65	21	should	should	MD
cord-017337-vq3edhxn	65	22	be	be	VB
cord-017337-vq3edhxn	65	23	taken	take	VBN
cord-017337-vq3edhxn	65	24	into	into	IN
cord-017337-vq3edhxn	65	25	account	account	NN
cord-017337-vq3edhxn	65	26	when	when	WRB
cord-017337-vq3edhxn	65	27	considering	consider	VBG
cord-017337-vq3edhxn	65	28	the	the	DT
cord-017337-vq3edhxn	65	29	impact	impact	NN
cord-017337-vq3edhxn	65	30	of	of	IN
cord-017337-vq3edhxn	65	31	predisposition	predisposition	NN
cord-017337-vq3edhxn	65	32	on	on	IN
cord-017337-vq3edhxn	65	33	prognosis	prognosis	NN
cord-017337-vq3edhxn	65	34	,	,	,
cord-017337-vq3edhxn	65	35	to	to	TO
cord-017337-vq3edhxn	65	36	determine	determine	VB
cord-017337-vq3edhxn	65	37	which	which	WDT
cord-017337-vq3edhxn	65	38	carry	carry	VB
cord-017337-vq3edhxn	65	39	most	most	JJS
cord-017337-vq3edhxn	65	40	weight	weight	NN
cord-017337-vq3edhxn	65	41	,	,	,
cord-017337-vq3edhxn	65	42	and	and	CC
cord-017337-vq3edhxn	65	43	to	to	TO
cord-017337-vq3edhxn	65	44	identify	identify	VB
cord-017337-vq3edhxn	65	45	how	how	WRB
cord-017337-vq3edhxn	65	46	knowledge	knowledge	NN
cord-017337-vq3edhxn	65	47	of	of	IN
cord-017337-vq3edhxn	65	48	increased	increase	VBN
cord-017337-vq3edhxn	65	49	risks	risk	NNS
cord-017337-vq3edhxn	65	50	can	can	MD
cord-017337-vq3edhxn	65	51	be	be	VB
cord-017337-vq3edhxn	65	52	translated	translate	VBN
cord-017337-vq3edhxn	65	53	into	into	IN
cord-017337-vq3edhxn	65	54	improved	improve	VBN
cord-017337-vq3edhxn	65	55	clinical	clinical	JJ
cord-017337-vq3edhxn	65	56	outcomes	outcome	NNS
cord-017337-vq3edhxn	65	57	.	.	.
cord-017337-vq3edhxn	66	1	Advances	advance	NNS
cord-017337-vq3edhxn	66	2	in	in	IN
cord-017337-vq3edhxn	66	3	genetics	genetic	NNS
cord-017337-vq3edhxn	66	4	technology	technology	NN
cord-017337-vq3edhxn	66	5	now	now	RB
cord-017337-vq3edhxn	66	6	enable	enable	VBP
cord-017337-vq3edhxn	66	7	investigators	investigator	NNS
cord-017337-vq3edhxn	66	8	to	to	TO
cord-017337-vq3edhxn	66	9	create	create	VB
cord-017337-vq3edhxn	66	10	glass	glass	NN
cord-017337-vq3edhxn	66	11	slides	slide	NNS
cord-017337-vq3edhxn	66	12	(	(	-LRB-
cord-017337-vq3edhxn	66	13	chips	chip	NNS
cord-017337-vq3edhxn	66	14	)	)	-RRB-
cord-017337-vq3edhxn	66	15	with	with	IN
cord-017337-vq3edhxn	66	16	minute	minute	JJ
cord-017337-vq3edhxn	66	17	quantities	quantity	NNS
cord-017337-vq3edhxn	66	18	of	of	IN
cord-017337-vq3edhxn	66	19	short	short	JJ
cord-017337-vq3edhxn	66	20	,	,	,
cord-017337-vq3edhxn	66	21	gene	gene	NN
cord-017337-vq3edhxn	66	22	-	-	HYPH
cord-017337-vq3edhxn	66	23	specifi	specifi	VBN
cord-017337-vq3edhxn	66	24	c	c	NN
cord-017337-vq3edhxn	66	25	nucleotides	nucleotide	NNS
cord-017337-vq3edhxn	66	26	.	.	.
cord-017337-vq3edhxn	67	1	These	these	DT
cord-017337-vq3edhxn	67	2	gene	gene	NN
cord-017337-vq3edhxn	67	3	-	-	HYPH
cord-017337-vq3edhxn	67	4	specifi	specifi	VBN
cord-017337-vq3edhxn	67	5	c	c	NN
cord-017337-vq3edhxn	67	6	probe	probe	NN
cord-017337-vq3edhxn	67	7	nucleotides	nucleotide	NNS
cord-017337-vq3edhxn	67	8	,	,	,
cord-017337-vq3edhxn	67	9	ideally	ideally	RB
cord-017337-vq3edhxn	67	10	one	one	CD
cord-017337-vq3edhxn	67	11	for	for	IN
cord-017337-vq3edhxn	67	12	each	each	DT
cord-017337-vq3edhxn	67	13	gene	gene	NN
cord-017337-vq3edhxn	67	14	in	in	IN
cord-017337-vq3edhxn	67	15	the	the	DT
cord-017337-vq3edhxn	67	16	genome	genome	NN
cord-017337-vq3edhxn	67	17	,	,	,
cord-017337-vq3edhxn	67	18	are	be	VBP
cord-017337-vq3edhxn	67	19	arrayed	array	VBN
cord-017337-vq3edhxn	67	20	onto	onto	IN
cord-017337-vq3edhxn	67	21	the	the	DT
cord-017337-vq3edhxn	67	22	chip	chip	NN
cord-017337-vq3edhxn	67	23	surface	surface	NN
cord-017337-vq3edhxn	67	24	to	to	TO
cord-017337-vq3edhxn	67	25	produce	produce	VB
cord-017337-vq3edhxn	67	26	a	a	DT
cord-017337-vq3edhxn	67	27	DNA	dna	NN
cord-017337-vq3edhxn	67	28	microarray	microarray	NN
cord-017337-vq3edhxn	67	29	.	.	.
cord-017337-vq3edhxn	68	1	These	these	DT
cord-017337-vq3edhxn	68	2	can	can	MD
cord-017337-vq3edhxn	68	3	be	be	VB
cord-017337-vq3edhxn	68	4	used	use	VBN
cord-017337-vq3edhxn	68	5	to	to	TO
cord-017337-vq3edhxn	68	6	generate	generate	VB
cord-017337-vq3edhxn	68	7	an	an	DT
cord-017337-vq3edhxn	68	8	expression	expression	NN
cord-017337-vq3edhxn	68	9	profi	profi	NNP
cord-017337-vq3edhxn	68	10	le	le	NNP
cord-017337-vq3edhxn	68	11	,	,	,
cord-017337-vq3edhxn	68	12	the	the	DT
cord-017337-vq3edhxn	68	13	transcriptome	transcriptome	NN
cord-017337-vq3edhxn	68	14	,	,	,
cord-017337-vq3edhxn	68	15	for	for	IN
cord-017337-vq3edhxn	68	16	the	the	DT
cord-017337-vq3edhxn	68	17	cell	cell	NN
cord-017337-vq3edhxn	68	18	or	or	CC
cord-017337-vq3edhxn	68	19	tissue	tissue	NN
cord-017337-vq3edhxn	68	20	of	of	IN
cord-017337-vq3edhxn	68	21	interest	interest	NN
cord-017337-vq3edhxn	68	22	.	.	.
cord-017337-vq3edhxn	69	1	Genomics	genomic	NNS
cord-017337-vq3edhxn	69	2	,	,	,
cord-017337-vq3edhxn	69	3	and	and	CC
cord-017337-vq3edhxn	69	4	the	the	DT
cord-017337-vq3edhxn	69	5	broader	broad	JJR
cord-017337-vq3edhxn	69	6	fi	fi	NN
cord-017337-vq3edhxn	69	7	eld	eld	NN
cord-017337-vq3edhxn	69	8	of	of	IN
cord-017337-vq3edhxn	69	9	proteomics	proteomic	NNS
cord-017337-vq3edhxn	69	10	,	,	,
cord-017337-vq3edhxn	69	11	is	be	VBZ
cord-017337-vq3edhxn	69	12	likely	likely	JJ
cord-017337-vq3edhxn	69	13	to	to	TO
cord-017337-vq3edhxn	69	14	be	be	VB
cord-017337-vq3edhxn	69	15	increasingly	increasingly	RB
cord-017337-vq3edhxn	69	16	used	use	VBN
cord-017337-vq3edhxn	69	17	in	in	IN
cord-017337-vq3edhxn	69	18	routine	routine	JJ
cord-017337-vq3edhxn	69	19	patient	patient	NN
cord-017337-vq3edhxn	69	20	management	management	NN
cord-017337-vq3edhxn	69	21	in	in	IN
cord-017337-vq3edhxn	69	22	hospitals	hospital	NNS
cord-017337-vq3edhxn	69	23	of	of	IN
cord-017337-vq3edhxn	69	24	the	the	DT
cord-017337-vq3edhxn	69	25	future	future	NN
cord-017337-vq3edhxn	69	26	and	and	CC
cord-017337-vq3edhxn	69	27	will	will	MD
cord-017337-vq3edhxn	69	28	facilitate	facilitate	VB
cord-017337-vq3edhxn	69	29	the	the	DT
cord-017337-vq3edhxn	69	30	task	task	NN
cord-017337-vq3edhxn	69	31	of	of	IN
cord-017337-vq3edhxn	69	32	assessing	assess	VBG
cord-017337-vq3edhxn	69	33	predisposition	predisposition	NN
cord-017337-vq3edhxn	69	34	.	.	.
cord-017337-vq3edhxn	70	1	Four	four	CD
cord-017337-vq3edhxn	70	2	key	key	JJ
cord-017337-vq3edhxn	70	3	aspects	aspect	NNS
cord-017337-vq3edhxn	70	4	related	relate	VBN
cord-017337-vq3edhxn	70	5	to	to	IN
cord-017337-vq3edhxn	70	6	the	the	DT
cord-017337-vq3edhxn	70	7	underlying	underlie	VBG
cord-017337-vq3edhxn	70	8	infection	infection	NN
cord-017337-vq3edhxn	70	9	can	can	MD
cord-017337-vq3edhxn	70	10	infl	infl	XX
cord-017337-vq3edhxn	70	11	uence	uence	NN
cord-017337-vq3edhxn	70	12	management	management	NN
cord-017337-vq3edhxn	70	13	and	and	CC
cord-017337-vq3edhxn	70	14	prognosis	prognosis	NN
cord-017337-vq3edhxn	70	15	in	in	IN
cord-017337-vq3edhxn	70	16	patients	patient	NNS
cord-017337-vq3edhxn	70	17	with	with	IN
cord-017337-vq3edhxn	70	18	sepsis	sepsis	NN
cord-017337-vq3edhxn	70	19	:	:	:
cord-017337-vq3edhxn	70	20	source	source	NN
cord-017337-vq3edhxn	70	21	,	,	,
cord-017337-vq3edhxn	70	22	degree	degree	NN
cord-017337-vq3edhxn	70	23	,	,	,
cord-017337-vq3edhxn	70	24	hospital	hospital	NN
cord-017337-vq3edhxn	70	25	-	-	HYPH
cord-017337-vq3edhxn	70	26	acquired	acquire	VBN
cord-017337-vq3edhxn	70	27	versus	versus	IN
cord-017337-vq3edhxn	70	28	community	community	NN
cord-017337-vq3edhxn	70	29	-	-	HYPH
cord-017337-vq3edhxn	70	30	acquired	acquire	VBN
cord-017337-vq3edhxn	70	31	,	,	,
cord-017337-vq3edhxn	70	32	and	and	CC
cord-017337-vq3edhxn	70	33	microorganism	microorganism	NN
cord-017337-vq3edhxn	70	34	[	[	-LRB-
cord-017337-vq3edhxn	70	35	19	19	CD
cord-017337-vq3edhxn	70	36	]	]	-RRB-
cord-017337-vq3edhxn	70	37	.	.	.
cord-017337-vq3edhxn	71	1	In	in	IN
cord-017337-vq3edhxn	71	2	terms	term	NNS
cord-017337-vq3edhxn	71	3	of	of	IN
cord-017337-vq3edhxn	71	4	source	source	NN
cord-017337-vq3edhxn	71	5	,	,	,
cord-017337-vq3edhxn	71	6	for	for	IN
cord-017337-vq3edhxn	71	7	example	example	NN
cord-017337-vq3edhxn	71	8	,	,	,
cord-017337-vq3edhxn	71	9	infections	infection	NNS
cord-017337-vq3edhxn	71	10	of	of	IN
cord-017337-vq3edhxn	71	11	the	the	DT
cord-017337-vq3edhxn	71	12	urinary	urinary	JJ
cord-017337-vq3edhxn	71	13	tract	tract	NN
cord-017337-vq3edhxn	71	14	are	be	VBP
cord-017337-vq3edhxn	71	15	usually	usually	RB
cord-017337-vq3edhxn	71	16	less	less	RBR
cord-017337-vq3edhxn	71	17	severe	severe	JJ
cord-017337-vq3edhxn	71	18	than	than	IN
cord-017337-vq3edhxn	71	19	intra	intra	JJ
cord-017337-vq3edhxn	71	20	-	-	JJ
cord-017337-vq3edhxn	71	21	abdominal	abdominal	JJ
cord-017337-vq3edhxn	71	22	or	or	CC
cord-017337-vq3edhxn	71	23	pulmonary	pulmonary	JJ
cord-017337-vq3edhxn	71	24	infections	infection	NNS
cord-017337-vq3edhxn	71	25	.	.	.
cord-017337-vq3edhxn	72	1	In	in	IN
cord-017337-vq3edhxn	72	2	the	the	DT
cord-017337-vq3edhxn	72	3	Protein	Protein	NNP
cord-017337-vq3edhxn	72	4	C	C	NNP
cord-017337-vq3edhxn	72	5	Worldwide	Worldwide	NNP
cord-017337-vq3edhxn	72	6	Evaluation	Evaluation	NNP
cord-017337-vq3edhxn	72	7	in	in	IN
cord-017337-vq3edhxn	72	8	Severe	severe	JJ
cord-017337-vq3edhxn	72	9	Sepsis	sepsis	NN
cord-017337-vq3edhxn	72	10	(	(	-LRB-
cord-017337-vq3edhxn	72	11	PROWESS	prowess	NN
cord-017337-vq3edhxn	72	12	)	)	-RRB-
cord-017337-vq3edhxn	72	13	trial	trial	NN
cord-017337-vq3edhxn	72	14	[	[	-LRB-
cord-017337-vq3edhxn	72	15	20	20	CD
cord-017337-vq3edhxn	72	16	]	]	-RRB-
cord-017337-vq3edhxn	72	17	,	,	,
cord-017337-vq3edhxn	72	18	patients	patient	NNS
cord-017337-vq3edhxn	72	19	with	with	IN
cord-017337-vq3edhxn	72	20	urinary	urinary	JJ
cord-017337-vq3edhxn	72	21	tract	tract	NN
cord-017337-vq3edhxn	72	22	infections	infection	NNS
cord-017337-vq3edhxn	72	23	as	as	IN
cord-017337-vq3edhxn	72	24	a	a	DT
cord-017337-vq3edhxn	72	25	source	source	NN
cord-017337-vq3edhxn	72	26	of	of	IN
cord-017337-vq3edhxn	72	27	severe	severe	JJ
cord-017337-vq3edhxn	72	28	sepsis	sepsis	NN
cord-017337-vq3edhxn	72	29	had	have	VBD
cord-017337-vq3edhxn	72	30	a	a	DT
cord-017337-vq3edhxn	72	31	28-day	28-day	CD
cord-017337-vq3edhxn	72	32	all	all	DT
cord-017337-vq3edhxn	72	33	-	-	HYPH
cord-017337-vq3edhxn	72	34	cause	cause	NN
cord-017337-vq3edhxn	72	35	mortality	mortality	NN
cord-017337-vq3edhxn	72	36	of	of	IN
cord-017337-vq3edhxn	72	37	21	21	CD
cord-017337-vq3edhxn	72	38	%	%	NN
cord-017337-vq3edhxn	72	39	compared	compare	VBN
cord-017337-vq3edhxn	72	40	with	with	IN
cord-017337-vq3edhxn	72	41	patients	patient	NNS
cord-017337-vq3edhxn	72	42	with	with	IN
cord-017337-vq3edhxn	72	43	a	a	DT
cord-017337-vq3edhxn	72	44	pulmonary	pulmonary	JJ
cord-017337-vq3edhxn	72	45	source	source	NN
cord-017337-vq3edhxn	72	46	of	of	IN
cord-017337-vq3edhxn	72	47	sepsis	sepsis	NN
cord-017337-vq3edhxn	72	48	who	who	WP
cord-017337-vq3edhxn	72	49	had	have	VBD
cord-017337-vq3edhxn	72	50	a	a	DT
cord-017337-vq3edhxn	72	51	mortality	mortality	NN
cord-017337-vq3edhxn	72	52	rate	rate	NN
cord-017337-vq3edhxn	72	53	of	of	IN
cord-017337-vq3edhxn	72	54	34	34	CD
cord-017337-vq3edhxn	72	55	%	%	NN
cord-017337-vq3edhxn	72	56	(	(	-LRB-
cord-017337-vq3edhxn	72	57	p	p	NN
cord-017337-vq3edhxn	72	58	<	<	XX
cord-017337-vq3edhxn	72	59	.01	.01	NFP
cord-017337-vq3edhxn	72	60	)	)	-RRB-
cord-017337-vq3edhxn	72	61	.	.	.
cord-017337-vq3edhxn	73	1	The	the	DT
cord-017337-vq3edhxn	73	2	size	size	NN
cord-017337-vq3edhxn	73	3	of	of	IN
cord-017337-vq3edhxn	73	4	the	the	DT
cord-017337-vq3edhxn	73	5	inoculum	inoculum	NN
cord-017337-vq3edhxn	73	6	,	,	,
cord-017337-vq3edhxn	73	7	virulence	virulence	NN
cord-017337-vq3edhxn	73	8	,	,	,
cord-017337-vq3edhxn	73	9	and	and	CC
cord-017337-vq3edhxn	73	10	sensitivity	sensitivity	NN
cord-017337-vq3edhxn	73	11	of	of	IN
cord-017337-vq3edhxn	73	12	the	the	DT
cord-017337-vq3edhxn	73	13	infecting	infect	VBG
cord-017337-vq3edhxn	73	14	organisms	organism	NNS
cord-017337-vq3edhxn	73	15	are	be	VBP
cord-017337-vq3edhxn	73	16	also	also	RB
cord-017337-vq3edhxn	73	17	important	important	JJ
cord-017337-vq3edhxn	73	18	in	in	IN
cord-017337-vq3edhxn	73	19	determining	determine	VBG
cord-017337-vq3edhxn	73	20	outcomes	outcome	NNS
cord-017337-vq3edhxn	73	21	.	.	.
cord-017337-vq3edhxn	74	1	In	in	IN
cord-017337-vq3edhxn	74	2	the	the	DT
cord-017337-vq3edhxn	74	3	Sepsis	sepsis	NN
cord-017337-vq3edhxn	74	4	Occurrence	occurrence	NN
cord-017337-vq3edhxn	74	5	in	in	IN
cord-017337-vq3edhxn	74	6	Acutely	acutely	RB
cord-017337-vq3edhxn	74	7	Ill	Ill	NNP
cord-017337-vq3edhxn	74	8	Patients	patient	NNS
cord-017337-vq3edhxn	74	9	(	(	-LRB-
cord-017337-vq3edhxn	74	10	SOAP	SOAP	NNP
cord-017337-vq3edhxn	74	11	)	)	-RRB-
cord-017337-vq3edhxn	74	12	study	study	NN
cord-017337-vq3edhxn	74	13	,	,	,
cord-017337-vq3edhxn	74	14	infection	infection	NN
cord-017337-vq3edhxn	74	15	with	with	IN
cord-017337-vq3edhxn	74	16	Pseudomonas	Pseudomonas	NNP
cord-017337-vq3edhxn	74	17	spp	spp	NNS
cord-017337-vq3edhxn	74	18	.	.	.
cord-017337-vq3edhxn	75	1	was	be	VBD
cord-017337-vq3edhxn	75	2	independently	independently	RB
cord-017337-vq3edhxn	75	3	associated	associate	VBN
cord-017337-vq3edhxn	75	4	with	with	IN
cord-017337-vq3edhxn	75	5	increased	increase	VBN
cord-017337-vq3edhxn	75	6	ICU	ICU	NNP
cord-017337-vq3edhxn	75	7	mortality	mortality	NN
cord-017337-vq3edhxn	75	8	(	(	-LRB-
cord-017337-vq3edhxn	75	9	OR	or	CC
cord-017337-vq3edhxn	75	10	:	:	:
cord-017337-vq3edhxn	75	11	1.62	1.62	CD
cord-017337-vq3edhxn	75	12	[	[	-LRB-
cord-017337-vq3edhxn	75	13	95	95	CD
cord-017337-vq3edhxn	75	14	%	%	NN
cord-017337-vq3edhxn	75	15	CI	CI	NNP
cord-017337-vq3edhxn	75	16	1.09	1.09	CD
cord-017337-vq3edhxn	75	17	-	-	SYM
cord-017337-vq3edhxn	75	18	2.42	2.42	CD
cord-017337-vq3edhxn	75	19	]	]	-RRB-
cord-017337-vq3edhxn	75	20	,	,	,
cord-017337-vq3edhxn	75	21	p	p	NN
cord-017337-vq3edhxn	75	22	=	=	SYM
cord-017337-vq3edhxn	75	23	0.017	0.017	CD
cord-017337-vq3edhxn	75	24	)	)	-RRB-
cord-017337-vq3edhxn	75	25	[	[	-LRB-
cord-017337-vq3edhxn	75	26	16	16	CD
cord-017337-vq3edhxn	75	27	]	]	-RRB-
cord-017337-vq3edhxn	75	28	.	.	.
cord-017337-vq3edhxn	76	1	In	in	IN
cord-017337-vq3edhxn	76	2	a	a	DT
cord-017337-vq3edhxn	76	3	multicenter	multicenter	JJ
cord-017337-vq3edhxn	76	4	study	study	NN
cord-017337-vq3edhxn	76	5	from	from	IN
cord-017337-vq3edhxn	76	6	China	China	NNP
cord-017337-vq3edhxn	76	7	,	,	,
cord-017337-vq3edhxn	76	8	Gram	gram	NN
cord-017337-vq3edhxn	76	9	-	-	HYPH
cord-017337-vq3edhxn	76	10	positive	positive	JJ
cord-017337-vq3edhxn	76	11	bacterial	bacterial	JJ
cord-017337-vq3edhxn	76	12	infection	infection	NN
cord-017337-vq3edhxn	76	13	and	and	CC
cord-017337-vq3edhxn	76	14	invasive	invasive	JJ
cord-017337-vq3edhxn	76	15	fungal	fungal	JJ
cord-017337-vq3edhxn	76	16	infections	infection	NNS
cord-017337-vq3edhxn	76	17	were	be	VBD
cord-017337-vq3edhxn	76	18	risk	risk	NN
cord-017337-vq3edhxn	76	19	factors	factor	NNS
cord-017337-vq3edhxn	76	20	for	for	IN
cord-017337-vq3edhxn	76	21	hospital	hospital	NN
cord-017337-vq3edhxn	76	22	mortality	mortality	NN
cord-017337-vq3edhxn	76	23	[	[	-LRB-
cord-017337-vq3edhxn	76	24	21	21	CD
cord-017337-vq3edhxn	76	25	]	]	-RRB-
cord-017337-vq3edhxn	76	26	.	.	.
cord-017337-vq3edhxn	77	1	However	however	RB
cord-017337-vq3edhxn	77	2	,	,	,
cord-017337-vq3edhxn	77	3	classifying	classify	VBG
cord-017337-vq3edhxn	77	4	the	the	DT
cord-017337-vq3edhxn	77	5	relative	relative	JJ
cord-017337-vq3edhxn	77	6	importance	importance	NN
cord-017337-vq3edhxn	77	7	of	of	IN
cord-017337-vq3edhxn	77	8	infections	infection	NNS
cord-017337-vq3edhxn	77	9	on	on	IN
cord-017337-vq3edhxn	77	10	outcome	outcome	NN
cord-017337-vq3edhxn	77	11	can	can	MD
cord-017337-vq3edhxn	77	12	be	be	VB
cord-017337-vq3edhxn	77	13	diffi	diffi	JJ
cord-017337-vq3edhxn	77	14	cult	cult	NN
cord-017337-vq3edhxn	77	15	.	.	.
cord-017337-vq3edhxn	78	1	Cohen	Cohen	NNP
cord-017337-vq3edhxn	78	2	et	et	NNP
cord-017337-vq3edhxn	78	3	al	al	NNP
cord-017337-vq3edhxn	78	4	.	.	.
cord-017337-vq3edhxn	79	1	[	[	-LRB-
cord-017337-vq3edhxn	79	2	22	22	CD
cord-017337-vq3edhxn	79	3	]	]	-RRB-
cord-017337-vq3edhxn	79	4	recently	recently	RB
cord-017337-vq3edhxn	79	5	generated	generate	VBN
cord-017337-vq3edhxn	79	6	specifi	specifi	NNP
cord-017337-vq3edhxn	79	7	c	c	NNP
cord-017337-vq3edhxn	79	8	risk	risk	NN
cord-017337-vq3edhxn	79	9	codes	code	NNS
cord-017337-vq3edhxn	79	10	for	for	IN
cord-017337-vq3edhxn	79	11	the	the	DT
cord-017337-vq3edhxn	79	12	six	six	CD
cord-017337-vq3edhxn	79	13	most	most	RBS
cord-017337-vq3edhxn	79	14	common	common	JJ
cord-017337-vq3edhxn	79	15	infections	infection	NNS
cord-017337-vq3edhxn	79	16	:	:	:
cord-017337-vq3edhxn	79	17	bacteremia	bacteremia	NN
cord-017337-vq3edhxn	79	18	,	,	,
cord-017337-vq3edhxn	79	19	meningitis	meningitis	NN
cord-017337-vq3edhxn	79	20	,	,	,
cord-017337-vq3edhxn	79	21	pneumonia	pneumonia	NN
cord-017337-vq3edhxn	79	22	,	,	,
cord-017337-vq3edhxn	79	23	skin	skin	NN
cord-017337-vq3edhxn	79	24	and	and	CC
cord-017337-vq3edhxn	79	25	soft	soft	JJ
cord-017337-vq3edhxn	79	26	tissue	tissue	NN
cord-017337-vq3edhxn	79	27	infections	infection	NNS
cord-017337-vq3edhxn	79	28	,	,	,
cord-017337-vq3edhxn	79	29	peritonitis	peritonitis	NN
cord-017337-vq3edhxn	79	30	,	,	,
cord-017337-vq3edhxn	79	31	and	and	CC
cord-017337-vq3edhxn	79	32	urinary	urinary	JJ
cord-017337-vq3edhxn	79	33	tract	tract	JJ
cord-017337-vq3edhxn	79	34	infections	infection	NNS
cord-017337-vq3edhxn	79	35	.	.	.
cord-017337-vq3edhxn	80	1	For	for	IN
cord-017337-vq3edhxn	80	2	each	each	DT
cord-017337-vq3edhxn	80	3	infection	infection	NN
cord-017337-vq3edhxn	80	4	site	site	NN
cord-017337-vq3edhxn	80	5	and	and	CC
cord-017337-vq3edhxn	80	6	organism	organism	NN
cord-017337-vq3edhxn	80	7	,	,	,
cord-017337-vq3edhxn	80	8	a	a	DT
cord-017337-vq3edhxn	80	9	two	two	CD
cord-017337-vq3edhxn	80	10	-	-	HYPH
cord-017337-vq3edhxn	80	11	digit	digit	NN
cord-017337-vq3edhxn	80	12	code	code	NN
cord-017337-vq3edhxn	80	13	was	be	VBD
cord-017337-vq3edhxn	80	14	generated	generate	VBN
cord-017337-vq3edhxn	80	15	according	accord	VBG
cord-017337-vq3edhxn	80	16	to	to	IN
cord-017337-vq3edhxn	80	17	the	the	DT
cord-017337-vq3edhxn	80	18	mortality	mortality	NN
cord-017337-vq3edhxn	80	19	rate	rate	NN
cord-017337-vq3edhxn	80	20	associated	associate	VBN
cord-017337-vq3edhxn	80	21	with	with	IN
cord-017337-vq3edhxn	80	22	that	that	DT
cord-017337-vq3edhxn	80	23	infection	infection	NN
cord-017337-vq3edhxn	80	24	(	(	-LRB-
cord-017337-vq3edhxn	80	25	from	from	IN
cord-017337-vq3edhxn	80	26	1	1	CD
cord-017337-vq3edhxn	80	27	:	:	:
cord-017337-vq3edhxn	80	28	≤5	≤5	NN
cord-017337-vq3edhxn	80	29	%	%	NN
cord-017337-vq3edhxn	80	30	to	to	IN
cord-017337-vq3edhxn	80	31	4	4	CD
cord-017337-vq3edhxn	80	32	:	:	:
cord-017337-vq3edhxn	80	33	>	>	XX
cord-017337-vq3edhxn	80	34	30	30	CD
cord-017337-vq3edhxn	80	35	%	%	NN
cord-017337-vq3edhxn	80	36	)	)	-RRB-
cord-017337-vq3edhxn	80	37	,	,	,
cord-017337-vq3edhxn	80	38	and	and	CC
cord-017337-vq3edhxn	80	39	the	the	DT
cord-017337-vq3edhxn	80	40	level	level	NN
cord-017337-vq3edhxn	80	41	of	of	IN
cord-017337-vq3edhxn	80	42	evidence	evidence	NN
cord-017337-vq3edhxn	80	43	available	available	JJ
cord-017337-vq3edhxn	80	44	to	to	TO
cord-017337-vq3edhxn	80	45	support	support	VB
cord-017337-vq3edhxn	80	46	the	the	DT
cord-017337-vq3edhxn	80	47	mortality	mortality	NN
cord-017337-vq3edhxn	80	48	risk	risk	NN
cord-017337-vq3edhxn	80	49	(	(	-LRB-
cord-017337-vq3edhxn	80	50	level	level	NN
cord-017337-vq3edhxn	80	51	A	a	DT
cord-017337-vq3edhxn	80	52	representing	represent	VBG
cord-017337-vq3edhxn	80	53	evidence	evidence	NN
cord-017337-vq3edhxn	80	54	from	from	IN
cord-017337-vq3edhxn	80	55	more	more	JJR
cord-017337-vq3edhxn	80	56	than	than	IN
cord-017337-vq3edhxn	80	57	fi	fi	NNP
cord-017337-vq3edhxn	80	58	ve	ve	NNP
cord-017337-vq3edhxn	80	59	studies	study	NNS
cord-017337-vq3edhxn	80	60	with	with	IN
cord-017337-vq3edhxn	80	61	greater	great	JJR
cord-017337-vq3edhxn	80	62	than	than	IN
cord-017337-vq3edhxn	80	63	100	100	CD
cord-017337-vq3edhxn	80	64	patients	patient	NNS
cord-017337-vq3edhxn	80	65	,	,	,
cord-017337-vq3edhxn	80	66	through	through	IN
cord-017337-vq3edhxn	80	67	to	to	IN
cord-017337-vq3edhxn	80	68	level	level	NN
cord-017337-vq3edhxn	80	69	E	e	NN
cord-017337-vq3edhxn	80	70	where	where	WRB
cord-017337-vq3edhxn	80	71	there	there	EX
cord-017337-vq3edhxn	80	72	was	be	VBD
cord-017337-vq3edhxn	80	73	insuffi	insuffi	NNP
cord-017337-vq3edhxn	80	74	cient	cient	JJ
cord-017337-vq3edhxn	80	75	evidence	evidence	NN
cord-017337-vq3edhxn	80	76	from	from	IN
cord-017337-vq3edhxn	80	77	case	case	NN
cord-017337-vq3edhxn	80	78	reports	report	NNS
cord-017337-vq3edhxn	80	79	)	)	-RRB-
cord-017337-vq3edhxn	80	80	.	.	.
cord-017337-vq3edhxn	81	1	This	this	DT
cord-017337-vq3edhxn	81	2	Grading	Grading	NNP
cord-017337-vq3edhxn	81	3	System	system	NN
cord-017337-vq3edhxn	81	4	for	for	IN
cord-017337-vq3edhxn	81	5	Site	site	NN
cord-017337-vq3edhxn	81	6	and	and	CC
cord-017337-vq3edhxn	81	7	Severity	severity	NN
cord-017337-vq3edhxn	81	8	of	of	IN
cord-017337-vq3edhxn	81	9	Infection	infection	NN
cord-017337-vq3edhxn	81	10	(	(	-LRB-
cord-017337-vq3edhxn	81	11	GSSSI	GSSSI	NNP
cord-017337-vq3edhxn	81	12	)	)	-RRB-
cord-017337-vq3edhxn	81	13	needs	need	VBZ
cord-017337-vq3edhxn	81	14	to	to	TO
cord-017337-vq3edhxn	81	15	be	be	VB
cord-017337-vq3edhxn	81	16	validated	validate	VBN
cord-017337-vq3edhxn	81	17	,	,	,
cord-017337-vq3edhxn	81	18	but	but	CC
cord-017337-vq3edhxn	81	19	could	could	MD
cord-017337-vq3edhxn	81	20	be	be	VB
cord-017337-vq3edhxn	81	21	a	a	DT
cord-017337-vq3edhxn	81	22	useful	useful	JJ
cord-017337-vq3edhxn	81	23	means	mean	NNS
cord-017337-vq3edhxn	81	24	of	of	IN
cord-017337-vq3edhxn	81	25	characterizing	characterize	VBG
cord-017337-vq3edhxn	81	26	the	the	DT
cord-017337-vq3edhxn	81	27	risks	risk	NNS
cord-017337-vq3edhxn	81	28	associated	associate	VBN
cord-017337-vq3edhxn	81	29	with	with	IN
cord-017337-vq3edhxn	81	30	infections	infection	NNS
cord-017337-vq3edhxn	81	31	caused	cause	VBN
cord-017337-vq3edhxn	81	32	by	by	IN
cord-017337-vq3edhxn	81	33	various	various	JJ
cord-017337-vq3edhxn	81	34	organisms	organism	NNS
cord-017337-vq3edhxn	81	35	in	in	IN
cord-017337-vq3edhxn	81	36	different	different	JJ
cord-017337-vq3edhxn	81	37	sites	site	NNS
cord-017337-vq3edhxn	81	38	.	.	.
cord-017337-vq3edhxn	82	1	The	the	DT
cord-017337-vq3edhxn	82	2	timing	timing	NN
cord-017337-vq3edhxn	82	3	of	of	IN
cord-017337-vq3edhxn	82	4	the	the	DT
cord-017337-vq3edhxn	82	5	onset	onset	NN
cord-017337-vq3edhxn	82	6	of	of	IN
cord-017337-vq3edhxn	82	7	infection	infection	NN
cord-017337-vq3edhxn	82	8	may	may	MD
cord-017337-vq3edhxn	82	9	also	also	RB
cord-017337-vq3edhxn	82	10	infl	infl	VB
cord-017337-vq3edhxn	82	11	uence	uence	NN
cord-017337-vq3edhxn	82	12	outcomes	outcome	NNS
cord-017337-vq3edhxn	82	13	.	.	.
cord-017337-vq3edhxn	83	1	One	one	CD
cord-017337-vq3edhxn	83	2	study	study	NN
cord-017337-vq3edhxn	83	3	showed	show	VBD
cord-017337-vq3edhxn	83	4	that	that	IN
cord-017337-vq3edhxn	83	5	patients	patient	NNS
cord-017337-vq3edhxn	83	6	who	who	WP
cord-017337-vq3edhxn	83	7	developed	develop	VBD
cord-017337-vq3edhxn	83	8	septic	septic	JJ
cord-017337-vq3edhxn	83	9	shock	shock	NN
cord-017337-vq3edhxn	83	10	within	within	IN
cord-017337-vq3edhxn	83	11	24	24	CD
cord-017337-vq3edhxn	83	12	h	h	NN
cord-017337-vq3edhxn	83	13	of	of	IN
cord-017337-vq3edhxn	83	14	ICU	ICU	NNP
cord-017337-vq3edhxn	83	15	admission	admission	NN
cord-017337-vq3edhxn	83	16	were	be	VBD
cord-017337-vq3edhxn	83	17	more	more	RBR
cord-017337-vq3edhxn	83	18	severely	severely	RB
cord-017337-vq3edhxn	83	19	ill	ill	JJ
cord-017337-vq3edhxn	83	20	,	,	,
cord-017337-vq3edhxn	83	21	but	but	CC
cord-017337-vq3edhxn	83	22	had	have	VBD
cord-017337-vq3edhxn	83	23	better	well	JJR
cord-017337-vq3edhxn	83	24	outcomes	outcome	NNS
cord-017337-vq3edhxn	83	25	,	,	,
cord-017337-vq3edhxn	83	26	than	than	IN
cord-017337-vq3edhxn	83	27	patients	patient	NNS
cord-017337-vq3edhxn	83	28	who	who	WP
cord-017337-vq3edhxn	83	29	became	become	VBD
cord-017337-vq3edhxn	83	30	hypotensive	hypotensive	JJ
cord-017337-vq3edhxn	83	31	later	later	RB
cord-017337-vq3edhxn	83	32	during	during	IN
cord-017337-vq3edhxn	83	33	their	-PRON-	PRP$
cord-017337-vq3edhxn	83	34	ICU	ICU	NNP
cord-017337-vq3edhxn	83	35	stay	stay	VBP
cord-017337-vq3edhxn	83	36	[	[	-LRB-
cord-017337-vq3edhxn	83	37	23	23	CD
cord-017337-vq3edhxn	83	38	]	]	-RRB-
cord-017337-vq3edhxn	83	39	.	.	.
cord-017337-vq3edhxn	84	1	Sepsis	sepsis	NN
cord-017337-vq3edhxn	84	2	is	be	VBZ
cord-017337-vq3edhxn	84	3	defi	defi	NNP
cord-017337-vq3edhxn	84	4	ned	ned	NNP
cord-017337-vq3edhxn	84	5	as	as	IN
cord-017337-vq3edhxn	84	6	the	the	DT
cord-017337-vq3edhxn	84	7	host	host	NN
cord-017337-vq3edhxn	84	8	response	response	NN
cord-017337-vq3edhxn	84	9	to	to	IN
cord-017337-vq3edhxn	84	10	infection	infection	NN
cord-017337-vq3edhxn	84	11	,	,	,
cord-017337-vq3edhxn	84	12	yet	yet	CC
cord-017337-vq3edhxn	84	13	that	that	IN
cord-017337-vq3edhxn	84	14	host	host	NN
cord-017337-vq3edhxn	84	15	response	response	NN
cord-017337-vq3edhxn	84	16	has	have	VBZ
cord-017337-vq3edhxn	84	17	proved	prove	VBN
cord-017337-vq3edhxn	84	18	difficult	difficult	JJ
cord-017337-vq3edhxn	84	19	to	to	TO
cord-017337-vq3edhxn	84	20	characterize	characterize	VB
cord-017337-vq3edhxn	84	21	[	[	-LRB-
cord-017337-vq3edhxn	84	22	24	24	CD
cord-017337-vq3edhxn	84	23	]	]	-RRB-
cord-017337-vq3edhxn	84	24	.	.	.
cord-017337-vq3edhxn	85	1	Various	various	JJ
cord-017337-vq3edhxn	85	2	approaches	approach	NNS
cord-017337-vq3edhxn	85	3	have	have	VBP
cord-017337-vq3edhxn	85	4	been	be	VBN
cord-017337-vq3edhxn	85	5	proposed	propose	VBN
cord-017337-vq3edhxn	85	6	,	,	,
cord-017337-vq3edhxn	85	7	including	include	VBG
cord-017337-vq3edhxn	85	8	the	the	DT
cord-017337-vq3edhxn	85	9	presence	presence	NN
cord-017337-vq3edhxn	85	10	of	of	IN
cord-017337-vq3edhxn	85	11	characteristic	characteristic	JJ
cord-017337-vq3edhxn	85	12	signs	sign	NNS
cord-017337-vq3edhxn	85	13	and	and	CC
cord-017337-vq3edhxn	85	14	symptoms	symptom	NNS
cord-017337-vq3edhxn	85	15	or	or	CC
cord-017337-vq3edhxn	85	16	the	the	DT
cord-017337-vq3edhxn	85	17	degree	degree	NN
cord-017337-vq3edhxn	85	18	of	of	IN
cord-017337-vq3edhxn	85	19	elevation	elevation	NN
cord-017337-vq3edhxn	85	20	of	of	IN
cord-017337-vq3edhxn	85	21	biological	biological	JJ
cord-017337-vq3edhxn	85	22	markers	marker	NNS
cord-017337-vq3edhxn	85	23	,	,	,
cord-017337-vq3edhxn	85	24	such	such	JJ
cord-017337-vq3edhxn	85	25	as	as	IN
cord-017337-vq3edhxn	85	26	procalcitonin	procalcitonin	NNS
cord-017337-vq3edhxn	85	27	or	or	CC
cord-017337-vq3edhxn	85	28	C	c	NN
cord-017337-vq3edhxn	85	29	-	-	HYPH
cord-017337-vq3edhxn	85	30	reactive	reactive	JJ
cord-017337-vq3edhxn	85	31	protein	protein	NN
cord-017337-vq3edhxn	85	32	,	,	,
cord-017337-vq3edhxn	85	33	but	but	CC
cord-017337-vq3edhxn	85	34	as	as	RB
cord-017337-vq3edhxn	85	35	yet	yet	RB
cord-017337-vq3edhxn	85	36	,	,	,
cord-017337-vq3edhxn	85	37	none	none	NN
cord-017337-vq3edhxn	85	38	of	of	IN
cord-017337-vq3edhxn	85	39	the	the	DT
cord-017337-vq3edhxn	85	40	suggested	suggest	VBN
cord-017337-vq3edhxn	85	41	markers	marker	NNS
cord-017337-vq3edhxn	85	42	is	be	VBZ
cord-017337-vq3edhxn	85	43	specifi	specifi	VBN
cord-017337-vq3edhxn	85	44	c	c	NN
cord-017337-vq3edhxn	85	45	for	for	IN
cord-017337-vq3edhxn	85	46	sepsis	sepsis	NN
cord-017337-vq3edhxn	85	47	.	.	.
cord-017337-vq3edhxn	86	1	Importantly	importantly	RB
cord-017337-vq3edhxn	86	2	,	,	,
cord-017337-vq3edhxn	86	3	the	the	DT
cord-017337-vq3edhxn	86	4	initial	initial	JJ
cord-017337-vq3edhxn	86	5	theory	theory	NN
cord-017337-vq3edhxn	86	6	that	that	IN
cord-017337-vq3edhxn	86	7	sepsis	sepsis	NN
cord-017337-vq3edhxn	86	8	was	be	VBD
cord-017337-vq3edhxn	86	9	simply	simply	RB
cord-017337-vq3edhxn	86	10	an	an	DT
cord-017337-vq3edhxn	86	11	uncontrolled	uncontrolled	JJ
cord-017337-vq3edhxn	86	12	infl	infl	NN
cord-017337-vq3edhxn	86	13	ammatory	ammatory	NN
cord-017337-vq3edhxn	86	14	response	response	NN
cord-017337-vq3edhxn	86	15	and	and	CC
cord-017337-vq3edhxn	86	16	could	could	MD
cord-017337-vq3edhxn	86	17	be	be	VB
cord-017337-vq3edhxn	86	18	treated	treat	VBN
cord-017337-vq3edhxn	86	19	by	by	IN
cord-017337-vq3edhxn	86	20	blocking	block	VBG
cord-017337-vq3edhxn	86	21	or	or	CC
cord-017337-vq3edhxn	86	22	removing	remove	VBG
cord-017337-vq3edhxn	86	23	any	any	DT
cord-017337-vq3edhxn	86	24	or	or	CC
cord-017337-vq3edhxn	86	25	several	several	JJ
cord-017337-vq3edhxn	86	26	of	of	IN
cord-017337-vq3edhxn	86	27	the	the	DT
cord-017337-vq3edhxn	86	28	proinfl	proinfl	NNP
cord-017337-vq3edhxn	86	29	ammatory	ammatory	NNP
cord-017337-vq3edhxn	86	30	cytokines	cytokine	NNS
cord-017337-vq3edhxn	86	31	has	have	VBZ
cord-017337-vq3edhxn	86	32	been	be	VBN
cord-017337-vq3edhxn	86	33	replaced	replace	VBN
cord-017337-vq3edhxn	86	34	by	by	IN
cord-017337-vq3edhxn	86	35	the	the	DT
cord-017337-vq3edhxn	86	36	realization	realization	NN
cord-017337-vq3edhxn	86	37	that	that	IN
cord-017337-vq3edhxn	86	38	the	the	DT
cord-017337-vq3edhxn	86	39	infl	infl	NNP
cord-017337-vq3edhxn	86	40	ammatory	ammatory	NNP
cord-017337-vq3edhxn	86	41	response	response	NN
cord-017337-vq3edhxn	86	42	is	be	VBZ
cord-017337-vq3edhxn	86	43	a	a	DT
cord-017337-vq3edhxn	86	44	normal	normal	JJ
cord-017337-vq3edhxn	86	45	and	and	CC
cord-017337-vq3edhxn	86	46	necessary	necessary	JJ
cord-017337-vq3edhxn	86	47	response	response	NN
cord-017337-vq3edhxn	86	48	to	to	IN
cord-017337-vq3edhxn	86	49	infection	infection	NN
cord-017337-vq3edhxn	86	50	,	,	,
cord-017337-vq3edhxn	86	51	and	and	CC
cord-017337-vq3edhxn	86	52	interrupting	interrupt	VBG
cord-017337-vq3edhxn	86	53	that	that	DT
cord-017337-vq3edhxn	86	54	response	response	NN
cord-017337-vq3edhxn	86	55	at	at	IN
cord-017337-vq3edhxn	86	56	any	any	DT
cord-017337-vq3edhxn	86	57	point	point	NN
cord-017337-vq3edhxn	86	58	may	may	MD
cord-017337-vq3edhxn	86	59	do	do	VB
cord-017337-vq3edhxn	86	60	more	more	JJR
cord-017337-vq3edhxn	86	61	harm	harm	NN
cord-017337-vq3edhxn	86	62	than	than	IN
cord-017337-vq3edhxn	86	63	good	good	JJ
cord-017337-vq3edhxn	86	64	.	.	.
cord-017337-vq3edhxn	87	1	Indeed	indeed	RB
cord-017337-vq3edhxn	87	2	,	,	,
cord-017337-vq3edhxn	87	3	the	the	DT
cord-017337-vq3edhxn	87	4	early	early	JJ
cord-017337-vq3edhxn	87	5	hyperinfl	hyperinfl	NN
cord-017337-vq3edhxn	87	6	ammatory	ammatory	NN
cord-017337-vq3edhxn	87	7	phase	phase	NN
cord-017337-vq3edhxn	87	8	of	of	IN
cord-017337-vq3edhxn	87	9	sepsis	sepsis	NN
cord-017337-vq3edhxn	87	10	is	be	VBZ
cord-017337-vq3edhxn	87	11	soon	soon	RB
cord-017337-vq3edhxn	87	12	replaced	replace	VBN
cord-017337-vq3edhxn	87	13	by	by	IN
cord-017337-vq3edhxn	87	14	a	a	DT
cord-017337-vq3edhxn	87	15	hypoinfl	hypoinfl	NNP
cord-017337-vq3edhxn	87	16	ammatory	ammatory	NNP
cord-017337-vq3edhxn	87	17	state	state	NN
cord-017337-vq3edhxn	87	18	.	.	.
cord-017337-vq3edhxn	88	1	The	the	DT
cord-017337-vq3edhxn	88	2	host	host	NN
cord-017337-vq3edhxn	88	3	response	response	NN
cord-017337-vq3edhxn	88	4	to	to	IN
cord-017337-vq3edhxn	88	5	infection	infection	NN
cord-017337-vq3edhxn	88	6	thus	thus	RB
cord-017337-vq3edhxn	88	7	varies	vary	VBZ
cord-017337-vq3edhxn	88	8	between	between	IN
cord-017337-vq3edhxn	88	9	patients	patient	NNS
cord-017337-vq3edhxn	88	10	and	and	CC
cord-017337-vq3edhxn	88	11	with	with	IN
cord-017337-vq3edhxn	88	12	time	time	NN
cord-017337-vq3edhxn	88	13	in	in	IN
cord-017337-vq3edhxn	88	14	the	the	DT
cord-017337-vq3edhxn	88	15	same	same	JJ
cord-017337-vq3edhxn	88	16	patient	patient	NN
cord-017337-vq3edhxn	88	17	[	[	-LRB-
cord-017337-vq3edhxn	88	18	25	25	CD
cord-017337-vq3edhxn	88	19	]	]	-RRB-
cord-017337-vq3edhxn	88	20	.	.	.
cord-017337-vq3edhxn	89	1	This	this	DT
cord-017337-vq3edhxn	89	2	differentiation	differentiation	NN
cord-017337-vq3edhxn	89	3	is	be	VBZ
cord-017337-vq3edhxn	89	4	important	important	JJ
cord-017337-vq3edhxn	89	5	for	for	IN
cord-017337-vq3edhxn	89	6	therapeutic	therapeutic	JJ
cord-017337-vq3edhxn	89	7	decisions	decision	NNS
cord-017337-vq3edhxn	89	8	,	,	,
cord-017337-vq3edhxn	89	9	as	as	IN
cord-017337-vq3edhxn	89	10	antiinfl	antiinfl	NNP
cord-017337-vq3edhxn	89	11	ammatory	ammatory	NNP
cord-017337-vq3edhxn	89	12	therapies	therapy	NNS
cord-017337-vq3edhxn	89	13	may	may	MD
cord-017337-vq3edhxn	89	14	be	be	VB
cord-017337-vq3edhxn	89	15	harmful	harmful	JJ
cord-017337-vq3edhxn	89	16	if	if	IN
cord-017337-vq3edhxn	89	17	given	give	VBN
cord-017337-vq3edhxn	89	18	to	to	IN
cord-017337-vq3edhxn	89	19	a	a	DT
cord-017337-vq3edhxn	89	20	patient	patient	NN
cord-017337-vq3edhxn	89	21	who	who	WP
cord-017337-vq3edhxn	89	22	is	be	VBZ
cord-017337-vq3edhxn	89	23	already	already	RB
cord-017337-vq3edhxn	89	24	in	in	IN
cord-017337-vq3edhxn	89	25	the	the	DT
cord-017337-vq3edhxn	89	26	hypoinfl	hypoinfl	NNP
cord-017337-vq3edhxn	89	27	ammatory	ammatory	NNP
cord-017337-vq3edhxn	89	28	phase	phase	NN
cord-017337-vq3edhxn	89	29	;	;	:
cord-017337-vq3edhxn	89	30	such	such	PDT
cord-017337-vq3edhxn	89	31	a	a	DT
cord-017337-vq3edhxn	89	32	patient	patient	NN
cord-017337-vq3edhxn	89	33	may	may	MD
cord-017337-vq3edhxn	89	34	benefi	benefi	NNP
cord-017337-vq3edhxn	89	35	t	t	NNP
cord-017337-vq3edhxn	89	36	rather	rather	RB
cord-017337-vq3edhxn	89	37	from	from	IN
cord-017337-vq3edhxn	89	38	a	a	DT
cord-017337-vq3edhxn	89	39	proinfl	proinfl	NN
cord-017337-vq3edhxn	89	40	ammatory	ammatory	NNP
cord-017337-vq3edhxn	89	41	therapy	therapy	NN
cord-017337-vq3edhxn	89	42	to	to	TO
cord-017337-vq3edhxn	89	43	boost	boost	VB
cord-017337-vq3edhxn	89	44	their	-PRON-	PRP$
cord-017337-vq3edhxn	89	45	immune	immune	JJ
cord-017337-vq3edhxn	89	46	system	system	NN
cord-017337-vq3edhxn	89	47	.	.	.
cord-017337-vq3edhxn	90	1	As	as	IN
cord-017337-vq3edhxn	90	2	with	with	IN
cord-017337-vq3edhxn	90	3	genomics	genomic	NNS
cord-017337-vq3edhxn	90	4	,	,	,
cord-017337-vq3edhxn	90	5	technological	technological	JJ
cord-017337-vq3edhxn	90	6	advances	advance	NNS
cord-017337-vq3edhxn	90	7	now	now	RB
cord-017337-vq3edhxn	90	8	enable	enable	VBP
cord-017337-vq3edhxn	90	9	multiple	multiple	JJ
cord-017337-vq3edhxn	90	10	markers	marker	NNS
cord-017337-vq3edhxn	90	11	to	to	TO
cord-017337-vq3edhxn	90	12	be	be	VB
cord-017337-vq3edhxn	90	13	assessed	assess	VBN
cord-017337-vq3edhxn	90	14	simultaneously	simultaneously	RB
cord-017337-vq3edhxn	90	15	from	from	IN
cord-017337-vq3edhxn	90	16	small	small	JJ
cord-017337-vq3edhxn	90	17	blood	blood	NN
cord-017337-vq3edhxn	90	18	samples	sample	NNS
cord-017337-vq3edhxn	90	19	.	.	.
cord-017337-vq3edhxn	91	1	This	this	DT
cord-017337-vq3edhxn	91	2	approach	approach	NN
cord-017337-vq3edhxn	91	3	could	could	MD
cord-017337-vq3edhxn	91	4	provide	provide	VB
cord-017337-vq3edhxn	91	5	clinicians	clinician	NNS
cord-017337-vq3edhxn	91	6	with	with	IN
cord-017337-vq3edhxn	91	7	an	an	DT
cord-017337-vq3edhxn	91	8	immune	immune	JJ
cord-017337-vq3edhxn	91	9	profi	profi	NNP
cord-017337-vq3edhxn	91	10	le	le	FW
cord-017337-vq3edhxn	91	11	for	for	IN
cord-017337-vq3edhxn	91	12	individual	individual	JJ
cord-017337-vq3edhxn	91	13	patients	patient	NNS
cord-017337-vq3edhxn	91	14	.	.	.
cord-017337-vq3edhxn	92	1	Again	again	RB
cord-017337-vq3edhxn	92	2	,	,	,
cord-017337-vq3edhxn	92	3	considerable	considerable	JJ
cord-017337-vq3edhxn	92	4	research	research	NN
cord-017337-vq3edhxn	92	5	is	be	VBZ
cord-017337-vq3edhxn	92	6	needed	need	VBN
cord-017337-vq3edhxn	92	7	to	to	TO
cord-017337-vq3edhxn	92	8	indentify	indentify	VB
cord-017337-vq3edhxn	92	9	which	which	WDT
cord-017337-vq3edhxn	92	10	markers	marker	NNS
cord-017337-vq3edhxn	92	11	should	should	MD
cord-017337-vq3edhxn	92	12	be	be	VB
cord-017337-vq3edhxn	92	13	included	include	VBN
cord-017337-vq3edhxn	92	14	on	on	IN
cord-017337-vq3edhxn	92	15	such	such	JJ
cord-017337-vq3edhxn	92	16	microarrays	microarray	NNS
cord-017337-vq3edhxn	92	17	.	.	.
cord-017337-vq3edhxn	93	1	Furthermore	furthermore	RB
cord-017337-vq3edhxn	93	2	,	,	,
cord-017337-vq3edhxn	93	3	the	the	DT
cord-017337-vq3edhxn	93	4	optimal	optimal	JJ
cord-017337-vq3edhxn	93	5	set	set	NN
cord-017337-vq3edhxn	93	6	of	of	IN
cord-017337-vq3edhxn	93	7	biologic	biologic	JJ
cord-017337-vq3edhxn	93	8	markers	marker	NNS
cord-017337-vq3edhxn	93	9	for	for	IN
cord-017337-vq3edhxn	93	10	1	1	CD
cord-017337-vq3edhxn	93	11	any	any	DT
cord-017337-vq3edhxn	93	12	patient	patient	NN
cord-017337-vq3edhxn	93	13	may	may	MD
cord-017337-vq3edhxn	93	14	depend	depend	VB
cord-017337-vq3edhxn	93	15	on	on	IN
cord-017337-vq3edhxn	93	16	the	the	DT
cord-017337-vq3edhxn	93	17	therapy	therapy	NN
cord-017337-vq3edhxn	93	18	being	be	VBG
cord-017337-vq3edhxn	93	19	proposed	propose	VBN
cord-017337-vq3edhxn	93	20	[	[	-LRB-
cord-017337-vq3edhxn	93	21	5	5	CD
cord-017337-vq3edhxn	93	22	]	]	-RRB-
cord-017337-vq3edhxn	93	23	.	.	.
cord-017337-vq3edhxn	94	1	For	for	IN
cord-017337-vq3edhxn	94	2	example	example	NN
cord-017337-vq3edhxn	94	3	,	,	,
cord-017337-vq3edhxn	94	4	an	an	DT
cord-017337-vq3edhxn	94	5	indicator	indicator	NN
cord-017337-vq3edhxn	94	6	of	of	IN
cord-017337-vq3edhxn	94	7	dysregulation	dysregulation	NN
cord-017337-vq3edhxn	94	8	of	of	IN
cord-017337-vq3edhxn	94	9	the	the	DT
cord-017337-vq3edhxn	94	10	coagulation	coagulation	NN
cord-017337-vq3edhxn	94	11	system	system	NN
cord-017337-vq3edhxn	94	12	might	may	MD
cord-017337-vq3edhxn	94	13	be	be	VB
cord-017337-vq3edhxn	94	14	more	more	RBR
cord-017337-vq3edhxn	94	15	valuable	valuable	JJ
cord-017337-vq3edhxn	94	16	when	when	WRB
cord-017337-vq3edhxn	94	17	deciding	decide	VBG
cord-017337-vq3edhxn	94	18	whether	whether	IN
cord-017337-vq3edhxn	94	19	or	or	CC
cord-017337-vq3edhxn	94	20	not	not	RB
cord-017337-vq3edhxn	94	21	to	to	TO
cord-017337-vq3edhxn	94	22	give	give	VB
cord-017337-vq3edhxn	94	23	drotrecogin	drotrecogin	NNP
cord-017337-vq3edhxn	94	24	alfa	alfa	NNP
cord-017337-vq3edhxn	94	25	(	(	-LRB-
cord-017337-vq3edhxn	94	26	activated	activate	VBN
cord-017337-vq3edhxn	94	27	)	)	-RRB-
cord-017337-vq3edhxn	94	28	,	,	,
cord-017337-vq3edhxn	94	29	whereas	whereas	IN
cord-017337-vq3edhxn	94	30	a	a	DT
cord-017337-vq3edhxn	94	31	marker	marker	NN
cord-017337-vq3edhxn	94	32	of	of	IN
cord-017337-vq3edhxn	94	33	adrenal	adrenal	JJ
cord-017337-vq3edhxn	94	34	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	94	35	might	may	MD
cord-017337-vq3edhxn	94	36	be	be	VB
cord-017337-vq3edhxn	94	37	more	more	RBR
cord-017337-vq3edhxn	94	38	useful	useful	JJ
cord-017337-vq3edhxn	94	39	for	for	IN
cord-017337-vq3edhxn	94	40	determining	determine	VBG
cord-017337-vq3edhxn	94	41	whether	whether	IN
cord-017337-vq3edhxn	94	42	to	to	TO
cord-017337-vq3edhxn	94	43	give	give	VB
cord-017337-vq3edhxn	94	44	hydrocortisone	hydrocortisone	NN
cord-017337-vq3edhxn	94	45	.	.	.
cord-017337-vq3edhxn	95	1	Organ	organ	NN
cord-017337-vq3edhxn	95	2	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	95	3	in	in	IN
cord-017337-vq3edhxn	95	4	severe	severe	JJ
cord-017337-vq3edhxn	95	5	sepsis	sepsis	NN
cord-017337-vq3edhxn	95	6	is	be	VBZ
cord-017337-vq3edhxn	95	7	not	not	RB
cord-017337-vq3edhxn	95	8	a	a	DT
cord-017337-vq3edhxn	95	9	simple	simple	JJ
cord-017337-vq3edhxn	95	10	"	"	``
cord-017337-vq3edhxn	95	11	present	present	JJ
cord-017337-vq3edhxn	95	12	"	"	''
cord-017337-vq3edhxn	95	13	or	or	CC
cord-017337-vq3edhxn	95	14	"	"	``
cord-017337-vq3edhxn	95	15	absent	absent	JJ
cord-017337-vq3edhxn	95	16	"	"	''
cord-017337-vq3edhxn	95	17	variable	variable	JJ
cord-017337-vq3edhxn	95	18	,	,	,
cord-017337-vq3edhxn	95	19	but	but	CC
cord-017337-vq3edhxn	95	20	presents	present	VBZ
cord-017337-vq3edhxn	95	21	a	a	DT
cord-017337-vq3edhxn	95	22	continuous	continuous	JJ
cord-017337-vq3edhxn	95	23	spectrum	spectrum	NN
cord-017337-vq3edhxn	95	24	of	of	IN
cord-017337-vq3edhxn	95	25	varying	vary	VBG
cord-017337-vq3edhxn	95	26	severity	severity	NN
cord-017337-vq3edhxn	95	27	in	in	IN
cord-017337-vq3edhxn	95	28	different	different	JJ
cord-017337-vq3edhxn	95	29	organs	organ	NNS
cord-017337-vq3edhxn	95	30	over	over	IN
cord-017337-vq3edhxn	95	31	time	time	NN
cord-017337-vq3edhxn	95	32	[	[	-LRB-
cord-017337-vq3edhxn	95	33	26	26	CD
cord-017337-vq3edhxn	95	34	]	]	-RRB-
cord-017337-vq3edhxn	95	35	.	.	.
cord-017337-vq3edhxn	96	1	The	the	DT
cord-017337-vq3edhxn	96	2	degree	degree	NN
cord-017337-vq3edhxn	96	3	of	of	IN
cord-017337-vq3edhxn	96	4	organ	organ	NN
cord-017337-vq3edhxn	96	5	involvement	involvement	NN
cord-017337-vq3edhxn	96	6	can	can	MD
cord-017337-vq3edhxn	96	7	be	be	VB
cord-017337-vq3edhxn	96	8	assessed	assess	VBN
cord-017337-vq3edhxn	96	9	with	with	IN
cord-017337-vq3edhxn	96	10	various	various	JJ
cord-017337-vq3edhxn	96	11	scoring	scoring	NN
cord-017337-vq3edhxn	96	12	systems	system	NNS
cord-017337-vq3edhxn	96	13	,	,	,
cord-017337-vq3edhxn	96	14	such	such	JJ
cord-017337-vq3edhxn	96	15	as	as	IN
cord-017337-vq3edhxn	96	16	the	the	DT
cord-017337-vq3edhxn	96	17	Sequential	Sequential	NNP
cord-017337-vq3edhxn	96	18	Organ	Organ	NNP
cord-017337-vq3edhxn	96	19	Failure	Failure	NNP
cord-017337-vq3edhxn	96	20	Assessment	Assessment	NNP
cord-017337-vq3edhxn	96	21	(	(	-LRB-
cord-017337-vq3edhxn	96	22	SOFA	sofa	NN
cord-017337-vq3edhxn	96	23	)	)	-RRB-
cord-017337-vq3edhxn	96	24	[	[	-LRB-
cord-017337-vq3edhxn	96	25	27	27	CD
cord-017337-vq3edhxn	96	26	]	]	-RRB-
cord-017337-vq3edhxn	96	27	.	.	.
cord-017337-vq3edhxn	97	1	This	this	DT
cord-017337-vq3edhxn	97	2	system	system	NN
cord-017337-vq3edhxn	97	3	uses	use	VBZ
cord-017337-vq3edhxn	97	4	parameters	parameter	NNS
cord-017337-vq3edhxn	97	5	that	that	WDT
cord-017337-vq3edhxn	97	6	are	be	VBP
cord-017337-vq3edhxn	97	7	routinely	routinely	RB
cord-017337-vq3edhxn	97	8	available	available	JJ
cord-017337-vq3edhxn	97	9	in	in	IN
cord-017337-vq3edhxn	97	10	all	all	DT
cord-017337-vq3edhxn	97	11	ICUs	icus	XX
cord-017337-vq3edhxn	97	12	to	to	TO
cord-017337-vq3edhxn	97	13	assess	assess	VB
cord-017337-vq3edhxn	97	14	the	the	DT
cord-017337-vq3edhxn	97	15	degree	degree	NN
cord-017337-vq3edhxn	97	16	of	of	IN
cord-017337-vq3edhxn	97	17	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	97	18	for	for	IN
cord-017337-vq3edhxn	97	19	six	six	CD
cord-017337-vq3edhxn	97	20	organ	organ	NN
cord-017337-vq3edhxn	97	21	systems	system	NNS
cord-017337-vq3edhxn	97	22	:	:	:
cord-017337-vq3edhxn	97	23	respiratory	respiratory	JJ
cord-017337-vq3edhxn	97	24	,	,	,
cord-017337-vq3edhxn	97	25	cardiovascular	cardiovascular	JJ
cord-017337-vq3edhxn	97	26	,	,	,
cord-017337-vq3edhxn	97	27	renal	renal	JJ
cord-017337-vq3edhxn	97	28	,	,	,
cord-017337-vq3edhxn	97	29	coagulation	coagulation	NN
cord-017337-vq3edhxn	97	30	,	,	,
cord-017337-vq3edhxn	97	31	neurologic	neurologic	JJ
cord-017337-vq3edhxn	97	32	,	,	,
cord-017337-vq3edhxn	97	33	and	and	CC
cord-017337-vq3edhxn	97	34	hepatic	hepatic	JJ
cord-017337-vq3edhxn	97	35	,	,	,
cord-017337-vq3edhxn	97	36	with	with	IN
cord-017337-vq3edhxn	97	37	a	a	DT
cord-017337-vq3edhxn	97	38	scale	scale	NN
cord-017337-vq3edhxn	97	39	of	of	IN
cord-017337-vq3edhxn	97	40	0	0	NFP
cord-017337-vq3edhxn	97	41	(	(	-LRB-
cord-017337-vq3edhxn	97	42	no	no	DT
cord-017337-vq3edhxn	97	43	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	97	44	)	)	-RRB-
cord-017337-vq3edhxn	97	45	to	to	IN
cord-017337-vq3edhxn	97	46	4	4	CD
cord-017337-vq3edhxn	97	47	for	for	IN
cord-017337-vq3edhxn	97	48	each	each	DT
cord-017337-vq3edhxn	97	49	organ	organ	NN
cord-017337-vq3edhxn	97	50	.	.	.
cord-017337-vq3edhxn	98	1	Importantly	importantly	RB
cord-017337-vq3edhxn	98	2	,	,	,
cord-017337-vq3edhxn	98	3	organ	organ	NN
cord-017337-vq3edhxn	98	4	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	98	5	can	can	MD
cord-017337-vq3edhxn	98	6	be	be	VB
cord-017337-vq3edhxn	98	7	recorded	record	VBN
cord-017337-vq3edhxn	98	8	for	for	IN
cord-017337-vq3edhxn	98	9	each	each	DT
cord-017337-vq3edhxn	98	10	organ	organ	NN
cord-017337-vq3edhxn	98	11	separately	separately	RB
cord-017337-vq3edhxn	98	12	or	or	CC
cord-017337-vq3edhxn	98	13	a	a	DT
cord-017337-vq3edhxn	98	14	composite	composite	JJ
cord-017337-vq3edhxn	98	15	score	score	NN
cord-017337-vq3edhxn	98	16	can	can	MD
cord-017337-vq3edhxn	98	17	be	be	VB
cord-017337-vq3edhxn	98	18	calculated	calculate	VBN
cord-017337-vq3edhxn	98	19	.	.	.
cord-017337-vq3edhxn	99	1	Thus	thus	RB
cord-017337-vq3edhxn	99	2	with	with	IN
cord-017337-vq3edhxn	99	3	repeated	repeat	VBN
cord-017337-vq3edhxn	99	4	scores	score	NNS
cord-017337-vq3edhxn	99	5	,	,	,
cord-017337-vq3edhxn	99	6	a	a	DT
cord-017337-vq3edhxn	99	7	dynamic	dynamic	JJ
cord-017337-vq3edhxn	99	8	picture	picture	NN
cord-017337-vq3edhxn	99	9	of	of	IN
cord-017337-vq3edhxn	99	10	the	the	DT
cord-017337-vq3edhxn	99	11	effects	effect	NNS
cord-017337-vq3edhxn	99	12	of	of	IN
cord-017337-vq3edhxn	99	13	sepsis	sepsis	NN
cord-017337-vq3edhxn	99	14	on	on	IN
cord-017337-vq3edhxn	99	15	individual	individual	JJ
cord-017337-vq3edhxn	99	16	or	or	CC
cord-017337-vq3edhxn	99	17	global	global	JJ
cord-017337-vq3edhxn	99	18	organ	organ	NN
cord-017337-vq3edhxn	99	19	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	99	20	can	can	MD
cord-017337-vq3edhxn	99	21	be	be	VB
cord-017337-vq3edhxn	99	22	developed	develop	VBN
cord-017337-vq3edhxn	99	23	.	.	.
cord-017337-vq3edhxn	100	1	Sequential	sequential	JJ
cord-017337-vq3edhxn	100	2	assessment	assessment	NN
cord-017337-vq3edhxn	100	3	of	of	IN
cord-017337-vq3edhxn	100	4	the	the	DT
cord-017337-vq3edhxn	100	5	SOFA	sofa	NN
cord-017337-vq3edhxn	100	6	score	score	NN
cord-017337-vq3edhxn	100	7	during	during	IN
cord-017337-vq3edhxn	100	8	the	the	DT
cord-017337-vq3edhxn	100	9	fi	fi	NN
cord-017337-vq3edhxn	100	10	rst	rst	NNP
cord-017337-vq3edhxn	100	11	few	few	JJ
cord-017337-vq3edhxn	100	12	days	day	NNS
cord-017337-vq3edhxn	100	13	of	of	IN
cord-017337-vq3edhxn	100	14	ICU	ICU	NNP
cord-017337-vq3edhxn	100	15	admission	admission	NN
cord-017337-vq3edhxn	100	16	has	have	VBZ
cord-017337-vq3edhxn	100	17	been	be	VBN
cord-017337-vq3edhxn	100	18	shown	show	VBN
cord-017337-vq3edhxn	100	19	to	to	TO
cord-017337-vq3edhxn	100	20	be	be	VB
cord-017337-vq3edhxn	100	21	a	a	DT
cord-017337-vq3edhxn	100	22	good	good	JJ
cord-017337-vq3edhxn	100	23	indicator	indicator	NN
cord-017337-vq3edhxn	100	24	of	of	IN
cord-017337-vq3edhxn	100	25	prognosis	prognosis	NN
cord-017337-vq3edhxn	100	26	,	,	,
cord-017337-vq3edhxn	100	27	with	with	IN
cord-017337-vq3edhxn	100	28	an	an	DT
cord-017337-vq3edhxn	100	29	increase	increase	NN
cord-017337-vq3edhxn	100	30	in	in	IN
cord-017337-vq3edhxn	100	31	SOFA	sofa	NN
cord-017337-vq3edhxn	100	32	score	score	NN
cord-017337-vq3edhxn	100	33	during	during	IN
cord-017337-vq3edhxn	100	34	the	the	DT
cord-017337-vq3edhxn	100	35	fi	fi	NNP
cord-017337-vq3edhxn	100	36	rst	rst	NNP
cord-017337-vq3edhxn	100	37	48	48	CD
cord-017337-vq3edhxn	100	38	h	h	NN
cord-017337-vq3edhxn	100	39	in	in	IN
cord-017337-vq3edhxn	100	40	the	the	DT
cord-017337-vq3edhxn	100	41	ICU	ICU	NNP
cord-017337-vq3edhxn	100	42	predicting	predict	VBG
cord-017337-vq3edhxn	100	43	a	a	DT
cord-017337-vq3edhxn	100	44	mortality	mortality	NN
cord-017337-vq3edhxn	100	45	rate	rate	NN
cord-017337-vq3edhxn	100	46	of	of	IN
cord-017337-vq3edhxn	100	47	at	at	RB
cord-017337-vq3edhxn	100	48	least	least	JJS
cord-017337-vq3edhxn	100	49	50	50	CD
cord-017337-vq3edhxn	100	50	%	%	NN
cord-017337-vq3edhxn	100	51	[	[	-LRB-
cord-017337-vq3edhxn	100	52	28	28	CD
cord-017337-vq3edhxn	100	53	]	]	-RRB-
cord-017337-vq3edhxn	100	54	.	.	.
cord-017337-vq3edhxn	101	1	Levy	Levy	NNP
cord-017337-vq3edhxn	101	2	et	et	NNP
cord-017337-vq3edhxn	101	3	al	al	NNP
cord-017337-vq3edhxn	101	4	.	.	NNP
cord-017337-vq3edhxn	101	5	reported	report	VBD
cord-017337-vq3edhxn	101	6	that	that	IN
cord-017337-vq3edhxn	101	7	early	early	JJ
cord-017337-vq3edhxn	101	8	improvement	improvement	NN
cord-017337-vq3edhxn	101	9	in	in	IN
cord-017337-vq3edhxn	101	10	cardiovascular	cardiovascular	JJ
cord-017337-vq3edhxn	101	11	,	,	,
cord-017337-vq3edhxn	101	12	renal	renal	JJ
cord-017337-vq3edhxn	101	13	,	,	,
cord-017337-vq3edhxn	101	14	or	or	CC
cord-017337-vq3edhxn	101	15	respiratory	respiratory	JJ
cord-017337-vq3edhxn	101	16	function	function	NN
cord-017337-vq3edhxn	101	17	from	from	IN
cord-017337-vq3edhxn	101	18	baseline	baseline	NN
cord-017337-vq3edhxn	101	19	to	to	IN
cord-017337-vq3edhxn	101	20	day	day	NN
cord-017337-vq3edhxn	101	21	1	1	CD
cord-017337-vq3edhxn	101	22	was	be	VBD
cord-017337-vq3edhxn	101	23	signifi	signifi	NNP
cord-017337-vq3edhxn	101	24	cantly	cantly	RB
cord-017337-vq3edhxn	101	25	related	relate	VBN
cord-017337-vq3edhxn	101	26	to	to	IN
cord-017337-vq3edhxn	101	27	survival	survival	NN
cord-017337-vq3edhxn	101	28	[	[	-LRB-
cord-017337-vq3edhxn	101	29	29	29	CD
cord-017337-vq3edhxn	101	30	]	]	-RRB-
cord-017337-vq3edhxn	101	31	.	.	.
cord-017337-vq3edhxn	102	1	Continued	continue	VBN
cord-017337-vq3edhxn	102	2	improvement	improvement	NN
cord-017337-vq3edhxn	102	3	in	in	IN
cord-017337-vq3edhxn	102	4	cardiovascular	cardiovascular	JJ
cord-017337-vq3edhxn	102	5	function	function	NN
cord-017337-vq3edhxn	102	6	before	before	IN
cord-017337-vq3edhxn	102	7	the	the	DT
cord-017337-vq3edhxn	102	8	start	start	NN
cord-017337-vq3edhxn	102	9	of	of	IN
cord-017337-vq3edhxn	102	10	day	day	NN
cord-017337-vq3edhxn	102	11	2	2	CD
cord-017337-vq3edhxn	102	12	and	and	CC
cord-017337-vq3edhxn	102	13	start	start	NN
cord-017337-vq3edhxn	102	14	of	of	IN
cord-017337-vq3edhxn	102	15	day	day	NN
cord-017337-vq3edhxn	102	16	3	3	CD
cord-017337-vq3edhxn	102	17	was	be	VBD
cord-017337-vq3edhxn	102	18	associated	associate	VBN
cord-017337-vq3edhxn	102	19	with	with	IN
cord-017337-vq3edhxn	102	20	further	further	JJ
cord-017337-vq3edhxn	102	21	improvement	improvement	NN
cord-017337-vq3edhxn	102	22	in	in	IN
cord-017337-vq3edhxn	102	23	survival	survival	NN
cord-017337-vq3edhxn	102	24	for	for	IN
cord-017337-vq3edhxn	102	25	patients	patient	NNS
cord-017337-vq3edhxn	102	26	who	who	WP
cord-017337-vq3edhxn	102	27	improved	improve	VBD
cord-017337-vq3edhxn	102	28	compared	compare	VBN
cord-017337-vq3edhxn	102	29	with	with	IN
cord-017337-vq3edhxn	102	30	those	those	DT
cord-017337-vq3edhxn	102	31	who	who	WP
cord-017337-vq3edhxn	102	32	worsened	worsen	VBD
cord-017337-vq3edhxn	102	33	.	.	.
cord-017337-vq3edhxn	103	1	In	in	IN
cord-017337-vq3edhxn	103	2	the	the	DT
cord-017337-vq3edhxn	103	3	future	future	NN
cord-017337-vq3edhxn	103	4	,	,	,
cord-017337-vq3edhxn	103	5	organ	organ	NN
cord-017337-vq3edhxn	103	6	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	103	7	scores	score	NNS
cord-017337-vq3edhxn	103	8	may	may	MD
cord-017337-vq3edhxn	103	9	be	be	VB
cord-017337-vq3edhxn	103	10	replaced	replace	VBN
cord-017337-vq3edhxn	103	11	by	by	IN
cord-017337-vq3edhxn	103	12	or	or	CC
cord-017337-vq3edhxn	103	13	combined	combine	VBN
cord-017337-vq3edhxn	103	14	with	with	IN
cord-017337-vq3edhxn	103	15	more	more	JJR
cord-017337-vq3edhxn	103	16	direct	direct	JJ
cord-017337-vq3edhxn	103	17	assessment	assessment	NN
cord-017337-vq3edhxn	103	18	of	of	IN
cord-017337-vq3edhxn	103	19	cellular	cellular	JJ
cord-017337-vq3edhxn	103	20	stress	stress	NN
cord-017337-vq3edhxn	103	21	and	and	CC
cord-017337-vq3edhxn	103	22	injury	injury	NN
cord-017337-vq3edhxn	103	23	,	,	,
cord-017337-vq3edhxn	103	24	for	for	IN
cord-017337-vq3edhxn	103	25	example	example	NN
cord-017337-vq3edhxn	103	26	,	,	,
cord-017337-vq3edhxn	103	27	measures	measure	NNS
cord-017337-vq3edhxn	103	28	of	of	IN
cord-017337-vq3edhxn	103	29	mitochondrial	mitochondrial	JJ
cord-017337-vq3edhxn	103	30	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	103	31	,	,	,
cord-017337-vq3edhxn	103	32	apoptosis	apoptosis	NN
cord-017337-vq3edhxn	103	33	,	,	,
cord-017337-vq3edhxn	103	34	or	or	CC
cord-017337-vq3edhxn	103	35	cytopathic	cytopathic	JJ
cord-017337-vq3edhxn	103	36	hypoxia	hypoxia	NN
cord-017337-vq3edhxn	103	37	.	.	.
cord-017337-vq3edhxn	104	1	The	the	DT
cord-017337-vq3edhxn	104	2	PIRO	PIRO	NNP
cord-017337-vq3edhxn	104	3	concept	concept	NN
cord-017337-vq3edhxn	104	4	at	at	IN
cord-017337-vq3edhxn	104	5	its	-PRON-	PRP$
cord-017337-vq3edhxn	104	6	simplest	simple	JJS
cord-017337-vq3edhxn	104	7	provides	provide	VBZ
cord-017337-vq3edhxn	104	8	a	a	DT
cord-017337-vq3edhxn	104	9	means	means	NN
cord-017337-vq3edhxn	104	10	of	of	IN
cord-017337-vq3edhxn	104	11	putting	put	VBG
cord-017337-vq3edhxn	104	12	some	some	DT
cord-017337-vq3edhxn	104	13	order	order	NN
cord-017337-vq3edhxn	104	14	to	to	IN
cord-017337-vq3edhxn	104	15	the	the	DT
cord-017337-vq3edhxn	104	16	various	various	JJ
cord-017337-vq3edhxn	104	17	aspects	aspect	NNS
cord-017337-vq3edhxn	104	18	of	of	IN
cord-017337-vq3edhxn	104	19	sepsis	sepsis	NN
cord-017337-vq3edhxn	104	20	.	.	.
cord-017337-vq3edhxn	105	1	Further	further	JJ
cord-017337-vq3edhxn	105	2	work	work	NN
cord-017337-vq3edhxn	105	3	is	be	VBZ
cord-017337-vq3edhxn	105	4	needed	need	VBN
cord-017337-vq3edhxn	105	5	to	to	TO
cord-017337-vq3edhxn	105	6	determine	determine	VB
cord-017337-vq3edhxn	105	7	exactly	exactly	RB
cord-017337-vq3edhxn	105	8	which	which	WDT
cord-017337-vq3edhxn	105	9	factors	factor	NNS
cord-017337-vq3edhxn	105	10	should	should	MD
cord-017337-vq3edhxn	105	11	be	be	VB
cord-017337-vq3edhxn	105	12	included	include	VBN
cord-017337-vq3edhxn	105	13	in	in	IN
cord-017337-vq3edhxn	105	14	each	each	DT
cord-017337-vq3edhxn	105	15	of	of	IN
cord-017337-vq3edhxn	105	16	the	the	DT
cord-017337-vq3edhxn	105	17	four	four	CD
cord-017337-vq3edhxn	105	18	components	component	NNS
cord-017337-vq3edhxn	105	19	and	and	CC
cord-017337-vq3edhxn	105	20	whether	whether	IN
cord-017337-vq3edhxn	105	21	or	or	CC
cord-017337-vq3edhxn	105	22	how	how	WRB
cord-017337-vq3edhxn	105	23	they	-PRON-	PRP
cord-017337-vq3edhxn	105	24	should	should	MD
cord-017337-vq3edhxn	105	25	be	be	VB
cord-017337-vq3edhxn	105	26	measured	measure	VBN
cord-017337-vq3edhxn	105	27	and	and	CC
cord-017337-vq3edhxn	105	28	weighted	weight	VBN
cord-017337-vq3edhxn	105	29	to	to	TO
cord-017337-vq3edhxn	105	30	achieve	achieve	VB
cord-017337-vq3edhxn	105	31	a	a	DT
cord-017337-vq3edhxn	105	32	quantitative	quantitative	JJ
cord-017337-vq3edhxn	105	33	measure	measure	NN
cord-017337-vq3edhxn	105	34	by	by	IN
cord-017337-vq3edhxn	105	35	which	which	WDT
cord-017337-vq3edhxn	105	36	heterogeneous	heterogeneous	JJ
cord-017337-vq3edhxn	105	37	groups	group	NNS
cord-017337-vq3edhxn	105	38	of	of	IN
cord-017337-vq3edhxn	105	39	septic	septic	JJ
cord-017337-vq3edhxn	105	40	patients	patient	NNS
cord-017337-vq3edhxn	105	41	could	could	MD
cord-017337-vq3edhxn	105	42	be	be	VB
cord-017337-vq3edhxn	105	43	characterized	characterize	VBN
cord-017337-vq3edhxn	105	44	and	and	CC
cord-017337-vq3edhxn	105	45	categorized	categorize	VBN
cord-017337-vq3edhxn	105	46	.	.	.
cord-017337-vq3edhxn	106	1	Once	once	RB
cord-017337-vq3edhxn	106	2	validated	validate	VBN
cord-017337-vq3edhxn	106	3	,	,	,
cord-017337-vq3edhxn	106	4	it	-PRON-	PRP
cord-017337-vq3edhxn	106	5	is	be	VBZ
cord-017337-vq3edhxn	106	6	possible	possible	JJ
cord-017337-vq3edhxn	106	7	that	that	IN
cord-017337-vq3edhxn	106	8	patients	patient	NNS
cord-017337-vq3edhxn	106	9	could	could	MD
cord-017337-vq3edhxn	106	10	receive	receive	VB
cord-017337-vq3edhxn	106	11	a	a	DT
cord-017337-vq3edhxn	106	12	PIRO	PIRO	NNP
cord-017337-vq3edhxn	106	13	grade	grade	NN
cord-017337-vq3edhxn	106	14	or	or	CC
cord-017337-vq3edhxn	106	15	stage	stage	NN
cord-017337-vq3edhxn	106	16	,	,	,
cord-017337-vq3edhxn	106	17	e.g.	e.g.	RB
cord-017337-vq3edhxn	106	18	,	,	,
cord-017337-vq3edhxn	106	19	P	p	NN
cord-017337-vq3edhxn	106	20	3	3	CD
cord-017337-vq3edhxn	106	21	I	i	NN
cord-017337-vq3edhxn	106	22	2	2	CD
cord-017337-vq3edhxn	106	23	R	r	NN
cord-017337-vq3edhxn	106	24	1	1	CD
cord-017337-vq3edhxn	106	25	O	o	NN
cord-017337-vq3edhxn	106	26	2	2	CD
cord-017337-vq3edhxn	106	27	,	,	,
cord-017337-vq3edhxn	106	28	which	which	WDT
cord-017337-vq3edhxn	106	29	would	would	MD
cord-017337-vq3edhxn	106	30	help	help	VB
cord-017337-vq3edhxn	106	31	direct	direct	JJ
cord-017337-vq3edhxn	106	32	treatment	treatment	NN
cord-017337-vq3edhxn	106	33	and	and	CC
cord-017337-vq3edhxn	106	34	indicate	indicate	VBP
cord-017337-vq3edhxn	106	35	prognosis	prognosis	NN
cord-017337-vq3edhxn	106	36	.	.	.
cord-017337-vq3edhxn	107	1	In	in	IN
cord-017337-vq3edhxn	107	2	addition	addition	NN
cord-017337-vq3edhxn	107	3	to	to	IN
cord-017337-vq3edhxn	107	4	characterizing	characterize	VBG
cord-017337-vq3edhxn	107	5	individual	individual	JJ
cord-017337-vq3edhxn	107	6	patients	patient	NNS
cord-017337-vq3edhxn	107	7	,	,	,
cord-017337-vq3edhxn	107	8	such	such	JJ
cord-017337-vq3edhxn	107	9	grades	grade	NNS
cord-017337-vq3edhxn	107	10	would	would	MD
cord-017337-vq3edhxn	107	11	facilitate	facilitate	VB
cord-017337-vq3edhxn	107	12	comparison	comparison	NN
cord-017337-vq3edhxn	107	13	of	of	IN
cord-017337-vq3edhxn	107	14	patient	patient	JJ
cord-017337-vq3edhxn	107	15	populations	population	NNS
cord-017337-vq3edhxn	107	16	for	for	IN
cord-017337-vq3edhxn	107	17	clinical	clinical	JJ
cord-017337-vq3edhxn	107	18	trial	trial	NN
cord-017337-vq3edhxn	107	19	purposes	purpose	NNS
cord-017337-vq3edhxn	107	20	and	and	CC
cord-017337-vq3edhxn	107	21	help	help	VB
cord-017337-vq3edhxn	107	22	focus	focus	VB
cord-017337-vq3edhxn	107	23	clinical	clinical	JJ
cord-017337-vq3edhxn	107	24	research	research	NN
cord-017337-vq3edhxn	107	25	.	.	.
cord-017337-vq3edhxn	108	1	Several	several	JJ
cord-017337-vq3edhxn	108	2	groups	group	NNS
cord-017337-vq3edhxn	108	3	have	have	VBP
cord-017337-vq3edhxn	108	4	already	already	RB
cord-017337-vq3edhxn	108	5	attempted	attempt	VBN
cord-017337-vq3edhxn	108	6	to	to	TO
cord-017337-vq3edhxn	108	7	apply	apply	VB
cord-017337-vq3edhxn	108	8	the	the	DT
cord-017337-vq3edhxn	108	9	PIRO	PIRO	NNP
cord-017337-vq3edhxn	108	10	system	system	NN
cord-017337-vq3edhxn	108	11	clinically	clinically	RB
cord-017337-vq3edhxn	108	12	and	and	CC
cord-017337-vq3edhxn	108	13	the	the	DT
cord-017337-vq3edhxn	108	14	results	result	NNS
cord-017337-vq3edhxn	108	15	of	of	IN
cord-017337-vq3edhxn	108	16	these	these	DT
cord-017337-vq3edhxn	108	17	studies	study	NNS
cord-017337-vq3edhxn	108	18	will	will	MD
cord-017337-vq3edhxn	108	19	be	be	VB
cord-017337-vq3edhxn	108	20	discussed	discuss	VBN
cord-017337-vq3edhxn	108	21	in	in	IN
cord-017337-vq3edhxn	108	22	more	more	JJR
cord-017337-vq3edhxn	108	23	detail	detail	NN
cord-017337-vq3edhxn	108	24	in	in	IN
cord-017337-vq3edhxn	108	25	later	later	JJ
cord-017337-vq3edhxn	108	26	chapters	chapter	NNS
cord-017337-vq3edhxn	108	27	.	.	.
cord-017337-vq3edhxn	109	1	Moreno	Moreno	NNP
cord-017337-vq3edhxn	109	2	et	et	NNP
cord-017337-vq3edhxn	109	3	al	al	NNP
cord-017337-vq3edhxn	109	4	.	.	NNP
cord-017337-vq3edhxn	109	5	used	use	VBD
cord-017337-vq3edhxn	109	6	the	the	DT
cord-017337-vq3edhxn	109	7	SAPS	SAPS	NNP
cord-017337-vq3edhxn	109	8	III	III	NNP
cord-017337-vq3edhxn	109	9	database	database	NN
cord-017337-vq3edhxn	109	10	to	to	TO
cord-017337-vq3edhxn	109	11	assess	assess	VB
cord-017337-vq3edhxn	109	12	whether	whether	IN
cord-017337-vq3edhxn	109	13	the	the	DT
cord-017337-vq3edhxn	109	14	PIRO	PIRO	NNP
cord-017337-vq3edhxn	109	15	system	system	NN
cord-017337-vq3edhxn	109	16	could	could	MD
cord-017337-vq3edhxn	109	17	be	be	VB
cord-017337-vq3edhxn	109	18	useful	useful	JJ
cord-017337-vq3edhxn	109	19	for	for	IN
cord-017337-vq3edhxn	109	20	predicting	predict	VBG
cord-017337-vq3edhxn	109	21	mortality	mortality	NN
cord-017337-vq3edhxn	109	22	in	in	IN
cord-017337-vq3edhxn	109	23	patients	patient	NNS
cord-017337-vq3edhxn	109	24	with	with	IN
cord-017337-vq3edhxn	109	25	sepsis	sepsis	NN
cord-017337-vq3edhxn	109	26	[	[	-LRB-
cord-017337-vq3edhxn	109	27	30	30	CD
cord-017337-vq3edhxn	109	28	]	]	-RRB-
cord-017337-vq3edhxn	109	29	.	.	.
cord-017337-vq3edhxn	110	1	For	for	IN
cord-017337-vq3edhxn	110	2	each	each	DT
cord-017337-vq3edhxn	110	3	of	of	IN
cord-017337-vq3edhxn	110	4	the	the	DT
cord-017337-vq3edhxn	110	5	four	four	CD
cord-017337-vq3edhxn	110	6	PIRO	PIRO	NNP
cord-017337-vq3edhxn	110	7	components	component	NNS
cord-017337-vq3edhxn	110	8	,	,	,
cord-017337-vq3edhxn	110	9	multivariate	multivariate	JJ
cord-017337-vq3edhxn	110	10	analysis	analysis	NN
cord-017337-vq3edhxn	110	11	was	be	VBD
cord-017337-vq3edhxn	110	12	used	use	VBN
cord-017337-vq3edhxn	110	13	to	to	TO
cord-017337-vq3edhxn	110	14	select	select	VB
cord-017337-vq3edhxn	110	15	variables	variable	NNS
cord-017337-vq3edhxn	110	16	signifi	signifi	NNP
cord-017337-vq3edhxn	110	17	cantly	cantly	RB
cord-017337-vq3edhxn	110	18	associated	associate	VBN
cord-017337-vq3edhxn	110	19	with	with	IN
cord-017337-vq3edhxn	110	20	hospital	hospital	NN
cord-017337-vq3edhxn	110	21	mortality	mortality	NN
cord-017337-vq3edhxn	110	22	,	,	,
cord-017337-vq3edhxn	110	23	which	which	WDT
cord-017337-vq3edhxn	110	24	were	be	VBD
cord-017337-vq3edhxn	110	25	then	then	RB
cord-017337-vq3edhxn	110	26	weighted	weight	VBN
cord-017337-vq3edhxn	110	27	and	and	CC
cord-017337-vq3edhxn	110	28	allocated	allocate	VBN
cord-017337-vq3edhxn	110	29	points	point	NNS
cord-017337-vq3edhxn	110	30	.	.	.
cord-017337-vq3edhxn	111	1	The	the	DT
cord-017337-vq3edhxn	111	2	authors	author	NNS
cord-017337-vq3edhxn	111	3	felt	feel	VBD
cord-017337-vq3edhxn	111	4	it	-PRON-	PRP
cord-017337-vq3edhxn	111	5	was	be	VBD
cord-017337-vq3edhxn	111	6	not	not	RB
cord-017337-vq3edhxn	111	7	possible	possible	JJ
cord-017337-vq3edhxn	111	8	to	to	TO
cord-017337-vq3edhxn	111	9	separate	separate	VB
cord-017337-vq3edhxn	111	10	host	host	NN
cord-017337-vq3edhxn	111	11	response	response	NN
cord-017337-vq3edhxn	111	12	from	from	IN
cord-017337-vq3edhxn	111	13	the	the	DT
cord-017337-vq3edhxn	111	14	resulting	result	VBG
cord-017337-vq3edhxn	111	15	organ	organ	NN
cord-017337-vq3edhxn	111	16	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	111	17	,	,	,
cord-017337-vq3edhxn	111	18	so	so	RB
cord-017337-vq3edhxn	111	19	they	-PRON-	PRP
cord-017337-vq3edhxn	111	20	combined	combine	VBD
cord-017337-vq3edhxn	111	21	these	these	DT
cord-017337-vq3edhxn	111	22	two	two	CD
cord-017337-vq3edhxn	111	23	components	component	NNS
cord-017337-vq3edhxn	111	24	.	.	.
cord-017337-vq3edhxn	112	1	For	for	IN
cord-017337-vq3edhxn	112	2	predisposition	predisposition	NN
cord-017337-vq3edhxn	112	3	,	,	,
cord-017337-vq3edhxn	112	4	the	the	DT
cord-017337-vq3edhxn	112	5	fi	fi	XX
cord-017337-vq3edhxn	112	6	nal	nal	FW
cord-017337-vq3edhxn	112	7	variables	variable	NNS
cord-017337-vq3edhxn	112	8	were	be	VBD
cord-017337-vq3edhxn	112	9	age	age	NN
cord-017337-vq3edhxn	112	10	,	,	,
cord-017337-vq3edhxn	112	11	location	location	NN
cord-017337-vq3edhxn	112	12	of	of	IN
cord-017337-vq3edhxn	112	13	patient	patient	NN
cord-017337-vq3edhxn	112	14	prior	prior	RB
cord-017337-vq3edhxn	112	15	to	to	IN
cord-017337-vq3edhxn	112	16	ICU	ICU	NNP
cord-017337-vq3edhxn	112	17	admission	admission	NN
cord-017337-vq3edhxn	112	18	,	,	,
cord-017337-vq3edhxn	112	19	length	length	NN
cord-017337-vq3edhxn	112	20	of	of	IN
cord-017337-vq3edhxn	112	21	stay	stay	NN
cord-017337-vq3edhxn	112	22	before	before	IN
cord-017337-vq3edhxn	112	23	ICU	ICU	NNP
cord-017337-vq3edhxn	112	24	admission	admission	NN
cord-017337-vq3edhxn	112	25	,	,	,
cord-017337-vq3edhxn	112	26	certain	certain	JJ
cord-017337-vq3edhxn	112	27	comorbidities	comorbiditie	NNS
cord-017337-vq3edhxn	112	28	(	(	-LRB-
cord-017337-vq3edhxn	112	29	cancer	cancer	NN
cord-017337-vq3edhxn	112	30	,	,	,
cord-017337-vq3edhxn	112	31	cirrhosis	cirrhosis	NN
cord-017337-vq3edhxn	112	32	,	,	,
cord-017337-vq3edhxn	112	33	acquired	acquire	VBD
cord-017337-vq3edhxn	112	34	immunodefi	immunodefi	NNP
cord-017337-vq3edhxn	112	35	ciency	ciency	NNP
cord-017337-vq3edhxn	112	36	syndrome	syndrome	NN
cord-017337-vq3edhxn	112	37	[	[	-LRB-
cord-017337-vq3edhxn	112	38	AIDS	AIDS	NNP
cord-017337-vq3edhxn	112	39	]	]	-RRB-
cord-017337-vq3edhxn	112	40	)	)	-RRB-
cord-017337-vq3edhxn	112	41	,	,	,
cord-017337-vq3edhxn	112	42	and	and	CC
cord-017337-vq3edhxn	112	43	cardiac	cardiac	JJ
cord-017337-vq3edhxn	112	44	arrest	arrest	NN
cord-017337-vq3edhxn	112	45	as	as	IN
cord-017337-vq3edhxn	112	46	the	the	DT
cord-017337-vq3edhxn	112	47	reason	reason	NN
cord-017337-vq3edhxn	112	48	for	for	IN
cord-017337-vq3edhxn	112	49	ICU	ICU	NNP
cord-017337-vq3edhxn	112	50	admission	admission	NN
cord-017337-vq3edhxn	112	51	;	;	:
cord-017337-vq3edhxn	112	52	for	for	IN
cord-017337-vq3edhxn	112	53	infection	infection	NN
cord-017337-vq3edhxn	112	54	,	,	,
cord-017337-vq3edhxn	112	55	the	the	DT
cord-017337-vq3edhxn	112	56	variables	variable	NNS
cord-017337-vq3edhxn	112	57	were	be	VBD
cord-017337-vq3edhxn	112	58	nosocomial	nosocomial	JJ
cord-017337-vq3edhxn	112	59	infection	infection	NN
cord-017337-vq3edhxn	112	60	,	,	,
cord-017337-vq3edhxn	112	61	respiratory	respiratory	JJ
cord-017337-vq3edhxn	112	62	infection	infection	NN
cord-017337-vq3edhxn	112	63	,	,	,
cord-017337-vq3edhxn	112	64	and	and	CC
cord-017337-vq3edhxn	112	65	infections	infection	NNS
cord-017337-vq3edhxn	112	66	by	by	IN
cord-017337-vq3edhxn	112	67	Candida	Candida	NNP
cord-017337-vq3edhxn	112	68	species	specie	NNS
cord-017337-vq3edhxn	112	69	or	or	CC
cord-017337-vq3edhxn	112	70	other	other	JJ
cord-017337-vq3edhxn	112	71	fungi	fungus	NNS
cord-017337-vq3edhxn	112	72	;	;	:
cord-017337-vq3edhxn	112	73	for	for	IN
cord-017337-vq3edhxn	112	74	response	response	NN
cord-017337-vq3edhxn	112	75	/	/	SYM
cord-017337-vq3edhxn	112	76	organ	organ	NN
cord-017337-vq3edhxn	112	77	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	112	78	,	,	,
cord-017337-vq3edhxn	112	79	the	the	DT
cord-017337-vq3edhxn	112	80	variables	variable	NNS
cord-017337-vq3edhxn	112	81	were	be	VBD
cord-017337-vq3edhxn	112	82	renal	renal	JJ
cord-017337-vq3edhxn	112	83	or	or	CC
cord-017337-vq3edhxn	112	84	coagulation	coagulation	NN
cord-017337-vq3edhxn	112	85	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	112	86	,	,	,
cord-017337-vq3edhxn	112	87	and	and	CC
cord-017337-vq3edhxn	112	88	failure	failure	NN
cord-017337-vq3edhxn	112	89	of	of	IN
cord-017337-vq3edhxn	112	90	the	the	DT
cord-017337-vq3edhxn	112	91	cardiovascular	cardiovascular	JJ
cord-017337-vq3edhxn	112	92	,	,	,
cord-017337-vq3edhxn	112	93	renal	renal	JJ
cord-017337-vq3edhxn	112	94	,	,	,
cord-017337-vq3edhxn	112	95	respiratory	respiratory	JJ
cord-017337-vq3edhxn	112	96	,	,	,
cord-017337-vq3edhxn	112	97	coagulation	coagulation	NN
cord-017337-vq3edhxn	112	98	,	,	,
cord-017337-vq3edhxn	112	99	or	or	CC
cord-017337-vq3edhxn	112	100	central	central	JJ
cord-017337-vq3edhxn	112	101	nervous	nervous	JJ
cord-017337-vq3edhxn	112	102	systems	system	NNS
cord-017337-vq3edhxn	112	103	.	.	.
cord-017337-vq3edhxn	113	1	The	the	DT
cord-017337-vq3edhxn	113	2	authors	author	NNS
cord-017337-vq3edhxn	113	3	suggested	suggest	VBD
cord-017337-vq3edhxn	113	4	that	that	IN
cord-017337-vq3edhxn	113	5	,	,	,
cord-017337-vq3edhxn	113	6	although	although	IN
cord-017337-vq3edhxn	113	7	further	further	JJ
cord-017337-vq3edhxn	113	8	prospective	prospective	JJ
cord-017337-vq3edhxn	113	9	validation	validation	NN
cord-017337-vq3edhxn	113	10	is	be	VBZ
cord-017337-vq3edhxn	113	11	needed	need	VBN
cord-017337-vq3edhxn	113	12	,	,	,
cord-017337-vq3edhxn	113	13	the	the	DT
cord-017337-vq3edhxn	113	14	proposed	propose	VBN
cord-017337-vq3edhxn	113	15	SAPS	SAPS	NNP
cord-017337-vq3edhxn	113	16	III	III	NNP
cord-017337-vq3edhxn	113	17	PIRO	PIRO	NNP
cord-017337-vq3edhxn	113	18	system	system	NN
cord-017337-vq3edhxn	113	19	could	could	MD
cord-017337-vq3edhxn	113	20	be	be	VB
cord-017337-vq3edhxn	113	21	used	use	VBN
cord-017337-vq3edhxn	113	22	to	to	TO
cord-017337-vq3edhxn	113	23	stratify	stratify	VB
cord-017337-vq3edhxn	113	24	patients	patient	NNS
cord-017337-vq3edhxn	113	25	at	at	IN
cord-017337-vq3edhxn	113	26	or	or	CC
cord-017337-vq3edhxn	113	27	shortly	shortly	RB
cord-017337-vq3edhxn	113	28	after	after	IN
cord-017337-vq3edhxn	113	29	ICU	ICU	NNP
cord-017337-vq3edhxn	113	30	admission	admission	NN
cord-017337-vq3edhxn	113	31	to	to	TO
cord-017337-vq3edhxn	113	32	enable	enable	VB
cord-017337-vq3edhxn	113	33	better	well	JJR
cord-017337-vq3edhxn	113	34	selection	selection	NN
cord-017337-vq3edhxn	113	35	of	of	IN
cord-017337-vq3edhxn	113	36	management	management	NN
cord-017337-vq3edhxn	113	37	according	accord	VBG
cord-017337-vq3edhxn	113	38	to	to	IN
cord-017337-vq3edhxn	113	39	the	the	DT
cord-017337-vq3edhxn	113	40	risk	risk	NN
cord-017337-vq3edhxn	113	41	of	of	IN
cord-017337-vq3edhxn	113	42	death	death	NN
cord-017337-vq3edhxn	113	43	[	[	-LRB-
cord-017337-vq3edhxn	113	44	30	30	CD
cord-017337-vq3edhxn	113	45	]	]	-RRB-
cord-017337-vq3edhxn	113	46	.	.	.
cord-017337-vq3edhxn	114	1	In	in	IN
cord-017337-vq3edhxn	114	2	a	a	DT
cord-017337-vq3edhxn	114	3	prospective	prospective	JJ
cord-017337-vq3edhxn	114	4	,	,	,
cord-017337-vq3edhxn	114	5	observational	observational	JJ
cord-017337-vq3edhxn	114	6	study	study	NN
cord-017337-vq3edhxn	114	7	,	,	,
cord-017337-vq3edhxn	114	8	Lisboa	Lisboa	NNP
cord-017337-vq3edhxn	114	9	et	et	NNP
cord-017337-vq3edhxn	114	10	al	al	NNP
cord-017337-vq3edhxn	114	11	.	.	.
cord-017337-vq3edhxn	115	1	[	[	-LRB-
cord-017337-vq3edhxn	115	2	31	31	CD
cord-017337-vq3edhxn	115	3	]	]	-RRB-
cord-017337-vq3edhxn	115	4	applied	apply	VBD
cord-017337-vq3edhxn	115	5	the	the	DT
cord-017337-vq3edhxn	115	6	PIRO	PIRO	NNP
cord-017337-vq3edhxn	115	7	concept	concept	NN
cord-017337-vq3edhxn	115	8	to	to	IN
cord-017337-vq3edhxn	115	9	patients	patient	NNS
cord-017337-vq3edhxn	115	10	with	with	IN
cord-017337-vq3edhxn	115	11	ventilator	ventilator	NN
cord-017337-vq3edhxn	115	12	-	-	HYPH
cord-017337-vq3edhxn	115	13	associated	associate	VBN
cord-017337-vq3edhxn	115	14	pneumonia	pneumonia	NN
cord-017337-vq3edhxn	115	15	(	(	-LRB-
cord-017337-vq3edhxn	115	16	VAP	VAP	NNP
cord-017337-vq3edhxn	115	17	)	)	-RRB-
cord-017337-vq3edhxn	115	18	,	,	,
cord-017337-vq3edhxn	115	19	again	again	RB
cord-017337-vq3edhxn	115	20	using	use	VBG
cord-017337-vq3edhxn	115	21	multivariate	multivariate	JJ
cord-017337-vq3edhxn	115	22	logistic	logistic	JJ
cord-017337-vq3edhxn	115	23	regression	regression	NN
cord-017337-vq3edhxn	115	24	to	to	TO
cord-017337-vq3edhxn	115	25	identify	identify	VB
cord-017337-vq3edhxn	115	26	variables	variable	NNS
cord-017337-vq3edhxn	115	27	independently	independently	RB
cord-017337-vq3edhxn	115	28	associated	associate	VBN
cord-017337-vq3edhxn	115	29	with	with	IN
cord-017337-vq3edhxn	115	30	ICU	ICU	NNP
cord-017337-vq3edhxn	115	31	mortality	mortality	NN
cord-017337-vq3edhxn	115	32	for	for	IN
cord-017337-vq3edhxn	115	33	inclusion	inclusion	NN
cord-017337-vq3edhxn	115	34	in	in	IN
cord-017337-vq3edhxn	115	35	the	the	DT
cord-017337-vq3edhxn	115	36	PIRO	PIRO	NNP
cord-017337-vq3edhxn	115	37	model	model	NN
cord-017337-vq3edhxn	115	38	.	.	.
cord-017337-vq3edhxn	116	1	In	in	IN
cord-017337-vq3edhxn	116	2	this	this	DT
cord-017337-vq3edhxn	116	3	study	study	NN
cord-017337-vq3edhxn	116	4	in	in	IN
cord-017337-vq3edhxn	116	5	VAP	VAP	NNP
cord-017337-vq3edhxn	116	6	patients	patient	NNS
cord-017337-vq3edhxn	116	7	,	,	,
cord-017337-vq3edhxn	116	8	the	the	DT
cord-017337-vq3edhxn	116	9	variables	variable	NNS
cord-017337-vq3edhxn	116	10	for	for	IN
cord-017337-vq3edhxn	116	11	predisposition	predisposition	NN
cord-017337-vq3edhxn	116	12	were	be	VBD
cord-017337-vq3edhxn	116	13	comorbidities	comorbiditie	NNS
cord-017337-vq3edhxn	116	14	(	(	-LRB-
cord-017337-vq3edhxn	116	15	COPD	COPD	NNP
cord-017337-vq3edhxn	116	16	,	,	,
cord-017337-vq3edhxn	116	17	immunocompromise	immunocompromise	NNP
cord-017337-vq3edhxn	116	18	,	,	,
cord-017337-vq3edhxn	116	19	heart	heart	NN
cord-017337-vq3edhxn	116	20	failure	failure	NN
cord-017337-vq3edhxn	116	21	,	,	,
cord-017337-vq3edhxn	116	22	cirrhosis	cirrhosis	NN
cord-017337-vq3edhxn	116	23	,	,	,
cord-017337-vq3edhxn	116	24	chronic	chronic	JJ
cord-017337-vq3edhxn	116	25	renal	renal	JJ
cord-017337-vq3edhxn	116	26	failure	failure	NN
cord-017337-vq3edhxn	116	27	)	)	-RRB-
cord-017337-vq3edhxn	116	28	;	;	:
cord-017337-vq3edhxn	116	29	for	for	IN
cord-017337-vq3edhxn	116	30	infection	infection	NN
cord-017337-vq3edhxn	116	31	,	,	,
cord-017337-vq3edhxn	116	32	the	the	DT
cord-017337-vq3edhxn	116	33	variable	variable	NN
cord-017337-vq3edhxn	116	34	was	be	VBD
cord-017337-vq3edhxn	116	35	bacteremia	bacteremia	NN
cord-017337-vq3edhxn	116	36	;	;	:
cord-017337-vq3edhxn	116	37	for	for	IN
cord-017337-vq3edhxn	116	38	response	response	NN
cord-017337-vq3edhxn	116	39	,	,	,
cord-017337-vq3edhxn	116	40	the	the	DT
cord-017337-vq3edhxn	116	41	variable	variable	NN
cord-017337-vq3edhxn	116	42	was	be	VBD
cord-017337-vq3edhxn	116	43	systolic	systolic	JJ
cord-017337-vq3edhxn	116	44	blood	blood	NN
cord-017337-vq3edhxn	116	45	pressure	pressure	NN
cord-017337-vq3edhxn	116	46	<	<	XX
cord-017337-vq3edhxn	116	47	90	90	CD
cord-017337-vq3edhxn	116	48	mmHg	mmHg	NNS
cord-017337-vq3edhxn	116	49	;	;	:
cord-017337-vq3edhxn	116	50	and	and	CC
cord-017337-vq3edhxn	116	51	for	for	IN
cord-017337-vq3edhxn	116	52	organ	organ	NN
cord-017337-vq3edhxn	116	53	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	116	54	,	,	,
cord-017337-vq3edhxn	116	55	the	the	DT
cord-017337-vq3edhxn	116	56	variable	variable	NN
cord-017337-vq3edhxn	116	57	was	be	VBD
cord-017337-vq3edhxn	116	58	acute	acute	JJ
cord-017337-vq3edhxn	116	59	respiratory	respiratory	JJ
cord-017337-vq3edhxn	116	60	distress	distress	NN
cord-017337-vq3edhxn	116	61	syndrome	syndrome	NN
cord-017337-vq3edhxn	116	62	(	(	-LRB-
cord-017337-vq3edhxn	116	63	ARDS	ARDS	NNP
cord-017337-vq3edhxn	116	64	)	)	-RRB-
cord-017337-vq3edhxn	116	65	.	.	.
cord-017337-vq3edhxn	117	1	A	a	DT
cord-017337-vq3edhxn	117	2	four	four	CD
cord-017337-vq3edhxn	117	3	-	-	HYPH
cord-017337-vq3edhxn	117	4	point	point	NN
cord-017337-vq3edhxn	117	5	score	score	NN
cord-017337-vq3edhxn	117	6	was	be	VBD
cord-017337-vq3edhxn	117	7	thus	thus	RB
cord-017337-vq3edhxn	117	8	developed	develop	VBN
cord-017337-vq3edhxn	117	9	,	,	,
cord-017337-vq3edhxn	117	10	with	with	IN
cord-017337-vq3edhxn	117	11	one	one	CD
cord-017337-vq3edhxn	117	12	point	point	NN
cord-017337-vq3edhxn	117	13	for	for	IN
cord-017337-vq3edhxn	117	14	each	each	DT
cord-017337-vq3edhxn	117	15	component	component	NN
cord-017337-vq3edhxn	117	16	.	.	.
cord-017337-vq3edhxn	118	1	Mortality	mortality	NN
cord-017337-vq3edhxn	118	2	increased	increase	VBD
cord-017337-vq3edhxn	118	3	with	with	IN
cord-017337-vq3edhxn	118	4	increasing	increase	VBG
cord-017337-vq3edhxn	118	5	score	score	NN
cord-017337-vq3edhxn	118	6	:	:	:
cord-017337-vq3edhxn	118	7	A	a	DT
cord-017337-vq3edhxn	118	8	score	score	NN
cord-017337-vq3edhxn	118	9	of	of	IN
cord-017337-vq3edhxn	118	10	0	0	CD
cord-017337-vq3edhxn	118	11	was	be	VBD
cord-017337-vq3edhxn	118	12	associated	associate	VBN
cord-017337-vq3edhxn	118	13	with	with	IN
cord-017337-vq3edhxn	118	14	a	a	DT
cord-017337-vq3edhxn	118	15	mortality	mortality	NN
cord-017337-vq3edhxn	118	16	rate	rate	NN
cord-017337-vq3edhxn	118	17	of	of	IN
cord-017337-vq3edhxn	118	18	9.8	9.8	CD
cord-017337-vq3edhxn	118	19	%	%	NN
cord-017337-vq3edhxn	118	20	,	,	,
cord-017337-vq3edhxn	118	21	increasing	increase	VBG
cord-017337-vq3edhxn	118	22	to	to	IN
cord-017337-vq3edhxn	118	23	93.3	93.3	CD
cord-017337-vq3edhxn	118	24	%	%	NN
cord-017337-vq3edhxn	118	25	for	for	IN
cord-017337-vq3edhxn	118	26	patients	patient	NNS
cord-017337-vq3edhxn	118	27	with	with	IN
cord-017337-vq3edhxn	118	28	a	a	DT
cord-017337-vq3edhxn	118	29	score	score	NN
cord-017337-vq3edhxn	118	30	of	of	IN
cord-017337-vq3edhxn	118	31	4	4	CD
cord-017337-vq3edhxn	118	32	.	.	.
cord-017337-vq3edhxn	119	1	These	these	DT
cord-017337-vq3edhxn	119	2	authors	author	NNS
cord-017337-vq3edhxn	119	3	suggested	suggest	VBD
cord-017337-vq3edhxn	119	4	that	that	IN
cord-017337-vq3edhxn	119	5	the	the	DT
cord-017337-vq3edhxn	119	6	VAP	VAP	NNP
cord-017337-vq3edhxn	119	7	-	-	HYPH
cord-017337-vq3edhxn	119	8	PIRO	PIRO	NNP
cord-017337-vq3edhxn	119	9	score	score	NN
cord-017337-vq3edhxn	119	10	could	could	MD
cord-017337-vq3edhxn	119	11	thus	thus	RB
cord-017337-vq3edhxn	119	12	be	be	VB
cord-017337-vq3edhxn	119	13	a	a	DT
cord-017337-vq3edhxn	119	14	useful	useful	JJ
cord-017337-vq3edhxn	119	15	practical	practical	JJ
cord-017337-vq3edhxn	119	16	tool	tool	NN
cord-017337-vq3edhxn	119	17	to	to	TO
cord-017337-vq3edhxn	119	18	predict	predict	VB
cord-017337-vq3edhxn	119	19	disease	disease	NN
cord-017337-vq3edhxn	119	20	severity	severity	NN
cord-017337-vq3edhxn	119	21	in	in	IN
cord-017337-vq3edhxn	119	22	patients	patient	NNS
cord-017337-vq3edhxn	119	23	with	with	IN
cord-017337-vq3edhxn	119	24	VAP	VAP	NNP
cord-017337-vq3edhxn	119	25	.	.	.
cord-017337-vq3edhxn	120	1	The	the	DT
cord-017337-vq3edhxn	120	2	two	two	CD
cord-017337-vq3edhxn	120	3	studies	study	NNS
cord-017337-vq3edhxn	120	4	discussed	discuss	VBD
cord-017337-vq3edhxn	120	5	briefl	briefl	NNP
cord-017337-vq3edhxn	120	6	y	y	NNP
cord-017337-vq3edhxn	120	7	above	above	RB
cord-017337-vq3edhxn	120	8	are	be	VBP
cord-017337-vq3edhxn	120	9	just	just	RB
cord-017337-vq3edhxn	120	10	two	two	CD
cord-017337-vq3edhxn	120	11	clinical	clinical	JJ
cord-017337-vq3edhxn	120	12	examples	example	NNS
cord-017337-vq3edhxn	120	13	of	of	IN
cord-017337-vq3edhxn	120	14	how	how	WRB
cord-017337-vq3edhxn	120	15	the	the	DT
cord-017337-vq3edhxn	120	16	PIRO	PIRO	NNP
cord-017337-vq3edhxn	120	17	system	system	NN
cord-017337-vq3edhxn	120	18	could	could	MD
cord-017337-vq3edhxn	120	19	be	be	VB
cord-017337-vq3edhxn	120	20	adopted	adopt	VBN
cord-017337-vq3edhxn	120	21	for	for	IN
cord-017337-vq3edhxn	120	22	use	use	NN
cord-017337-vq3edhxn	120	23	clinically	clinically	RB
cord-017337-vq3edhxn	120	24	.	.	.
cord-017337-vq3edhxn	121	1	Mortality	mortality	NN
cord-017337-vq3edhxn	121	2	remains	remain	VBZ
cord-017337-vq3edhxn	121	3	high	high	JJ
cord-017337-vq3edhxn	121	4	in	in	IN
cord-017337-vq3edhxn	121	5	patients	patient	NNS
cord-017337-vq3edhxn	121	6	with	with	IN
cord-017337-vq3edhxn	121	7	severe	severe	JJ
cord-017337-vq3edhxn	121	8	sepsis	sepsis	NN
cord-017337-vq3edhxn	121	9	(	(	-LRB-
cord-017337-vq3edhxn	121	10	around	around	IN
cord-017337-vq3edhxn	121	11	40	40	CD
cord-017337-vq3edhxn	121	12	%	%	NN
cord-017337-vq3edhxn	121	13	)	)	-RRB-
cord-017337-vq3edhxn	121	14	and	and	CC
cord-017337-vq3edhxn	121	15	septic	septic	JJ
cord-017337-vq3edhxn	121	16	shock	shock	NN
cord-017337-vq3edhxn	121	17	(	(	-LRB-
cord-017337-vq3edhxn	121	18	around	around	IN
cord-017337-vq3edhxn	121	19	60	60	CD
cord-017337-vq3edhxn	121	20	%	%	NN
cord-017337-vq3edhxn	121	21	)	)	-RRB-
cord-017337-vq3edhxn	121	22	and	and	CC
cord-017337-vq3edhxn	121	23	is	be	VBZ
cord-017337-vq3edhxn	121	24	closely	closely	RB
cord-017337-vq3edhxn	121	25	associated	associate	VBN
cord-017337-vq3edhxn	121	26	with	with	IN
cord-017337-vq3edhxn	121	27	the	the	DT
cord-017337-vq3edhxn	121	28	degree	degree	NN
cord-017337-vq3edhxn	121	29	of	of	IN
cord-017337-vq3edhxn	121	30	multiple	multiple	JJ
cord-017337-vq3edhxn	121	31	organ	organ	NN
cord-017337-vq3edhxn	121	32	failure	failure	NN
cord-017337-vq3edhxn	121	33	.	.	.
cord-017337-vq3edhxn	122	1	Results	result	NNS
cord-017337-vq3edhxn	122	2	from	from	IN
cord-017337-vq3edhxn	122	3	studies	study	NNS
cord-017337-vq3edhxn	122	4	of	of	IN
cord-017337-vq3edhxn	122	5	proposed	propose	VBN
cord-017337-vq3edhxn	122	6	new	new	JJ
cord-017337-vq3edhxn	122	7	interventions	intervention	NNS
cord-017337-vq3edhxn	122	8	in	in	IN
cord-017337-vq3edhxn	122	9	severe	severe	JJ
cord-017337-vq3edhxn	122	10	sepsis	sepsis	NN
cord-017337-vq3edhxn	122	11	have	have	VBP
cord-017337-vq3edhxn	122	12	largely	largely	RB
cord-017337-vq3edhxn	122	13	been	be	VBN
cord-017337-vq3edhxn	122	14	disappointing	disappointing	JJ
cord-017337-vq3edhxn	122	15	with	with	IN
cord-017337-vq3edhxn	122	16	few	few	JJ
cord-017337-vq3edhxn	122	17	demonstrating	demonstrate	VBG
cord-017337-vq3edhxn	122	18	any	any	DT
cord-017337-vq3edhxn	122	19	positive	positive	JJ
cord-017337-vq3edhxn	122	20	effect	effect	NN
cord-017337-vq3edhxn	122	21	on	on	IN
cord-017337-vq3edhxn	122	22	outcomes	outcome	NNS
cord-017337-vq3edhxn	122	23	.	.	.
cord-017337-vq3edhxn	123	1	One	one	CD
cord-017337-vq3edhxn	123	2	of	of	IN
cord-017337-vq3edhxn	123	3	the	the	DT
cord-017337-vq3edhxn	123	4	possible	possible	JJ
cord-017337-vq3edhxn	123	5	reasons	reason	NNS
cord-017337-vq3edhxn	123	6	for	for	IN
cord-017337-vq3edhxn	123	7	the	the	DT
cord-017337-vq3edhxn	123	8	multiple	multiple	JJ
cord-017337-vq3edhxn	123	9	"	"	``
cord-017337-vq3edhxn	123	10	failed	fail	VBN
cord-017337-vq3edhxn	123	11	"	"	''
cord-017337-vq3edhxn	123	12	trials	trial	NNS
cord-017337-vq3edhxn	123	13	is	be	VBZ
cord-017337-vq3edhxn	123	14	that	that	IN
cord-017337-vq3edhxn	123	15	the	the	DT
cord-017337-vq3edhxn	123	16	groups	group	NNS
cord-017337-vq3edhxn	123	17	of	of	IN
cord-017337-vq3edhxn	123	18	patients	patient	NNS
cord-017337-vq3edhxn	123	19	studied	study	VBN
cord-017337-vq3edhxn	123	20	have	have	VBP
cord-017337-vq3edhxn	123	21	been	be	VBN
cord-017337-vq3edhxn	123	22	too	too	RB
cord-017337-vq3edhxn	123	23	heterogeneous	heterogeneous	JJ
cord-017337-vq3edhxn	123	24	and	and	CC
cord-017337-vq3edhxn	123	25	that	that	IN
cord-017337-vq3edhxn	123	26	global	global	JJ
cord-017337-vq3edhxn	123	27	results	result	NNS
cord-017337-vq3edhxn	123	28	have	have	VBP
cord-017337-vq3edhxn	123	29	masked	mask	VBN
cord-017337-vq3edhxn	123	30	any	any	DT
cord-017337-vq3edhxn	123	31	potential	potential	JJ
cord-017337-vq3edhxn	123	32	benefi	benefi	NN
cord-017337-vq3edhxn	123	33	t	t	NN
cord-017337-vq3edhxn	123	34	in	in	IN
cord-017337-vq3edhxn	123	35	specifi	specifi	NNP
cord-017337-vq3edhxn	123	36	c	c	NNP
cord-017337-vq3edhxn	123	37	subgroups	subgroup	NNS
cord-017337-vq3edhxn	123	38	of	of	IN
cord-017337-vq3edhxn	123	39	patients	patient	NNS
cord-017337-vq3edhxn	123	40	[	[	-LRB-
cord-017337-vq3edhxn	123	41	32	32	CD
cord-017337-vq3edhxn	123	42	]	]	-RRB-
cord-017337-vq3edhxn	123	43	.	.	.
cord-017337-vq3edhxn	124	1	Better	well	RBR
cord-017337-vq3edhxn	124	2	targeting	targeting	NN
cord-017337-vq3edhxn	124	3	of	of	IN
cord-017337-vq3edhxn	124	4	proposed	propose	VBN
cord-017337-vq3edhxn	124	5	interventions	intervention	NNS
cord-017337-vq3edhxn	124	6	by	by	IN
cord-017337-vq3edhxn	124	7	better	well	JJR
cord-017337-vq3edhxn	124	8	characterization	characterization	NN
cord-017337-vq3edhxn	124	9	of	of	IN
cord-017337-vq3edhxn	124	10	septic	septic	JJ
cord-017337-vq3edhxn	124	11	patients	patient	NNS
cord-017337-vq3edhxn	124	12	with	with	IN
cord-017337-vq3edhxn	124	13	the	the	DT
cord-017337-vq3edhxn	124	14	PIRO	PIRO	NNP
cord-017337-vq3edhxn	124	15	system	system	NN
cord-017337-vq3edhxn	124	16	may	may	MD
cord-017337-vq3edhxn	124	17	lead	lead	VB
cord-017337-vq3edhxn	124	18	to	to	IN
cord-017337-vq3edhxn	124	19	better	well	JJR
cord-017337-vq3edhxn	124	20	outcomes	outcome	NNS
cord-017337-vq3edhxn	124	21	.	.	.
cord-017337-vq3edhxn	125	1	Improved	improved	JJ
cord-017337-vq3edhxn	125	2	classifi	classifi	NNP
cord-017337-vq3edhxn	125	3	cation	cation	NN
cord-017337-vq3edhxn	125	4	of	of	IN
cord-017337-vq3edhxn	125	5	septic	septic	JJ
cord-017337-vq3edhxn	125	6	patients	patient	NNS
cord-017337-vq3edhxn	125	7	using	use	VBG
cord-017337-vq3edhxn	125	8	the	the	DT
cord-017337-vq3edhxn	125	9	PIRO	PIRO	NNP
cord-017337-vq3edhxn	125	10	system	system	NN
cord-017337-vq3edhxn	125	11	may	may	MD
cord-017337-vq3edhxn	125	12	,	,	,
cord-017337-vq3edhxn	125	13	thus	thus	RB
cord-017337-vq3edhxn	125	14	,	,	,
cord-017337-vq3edhxn	125	15	facilitate	facilitate	VB
cord-017337-vq3edhxn	125	16	the	the	DT
cord-017337-vq3edhxn	125	17	development	development	NN
cord-017337-vq3edhxn	125	18	and	and	CC
cord-017337-vq3edhxn	125	19	evaluation	evaluation	NN
cord-017337-vq3edhxn	125	20	of	of	IN
cord-017337-vq3edhxn	125	21	clinical	clinical	JJ
cord-017337-vq3edhxn	125	22	trials	trial	NNS
cord-017337-vq3edhxn	125	23	of	of	IN
cord-017337-vq3edhxn	125	24	sepsis	sepsis	NN
cord-017337-vq3edhxn	125	25	therapies	therapy	NNS
cord-017337-vq3edhxn	125	26	and	and	CC
cord-017337-vq3edhxn	125	27	will	will	MD
cord-017337-vq3edhxn	125	28	also	also	RB
cord-017337-vq3edhxn	125	29	encourage	encourage	VB
cord-017337-vq3edhxn	125	30	further	further	JJ
cord-017337-vq3edhxn	125	31	study	study	NN
cord-017337-vq3edhxn	125	32	into	into	IN
cord-017337-vq3edhxn	125	33	the	the	DT
cord-017337-vq3edhxn	125	34	pathophysiology	pathophysiology	NN
cord-017337-vq3edhxn	125	35	and	and	CC
cord-017337-vq3edhxn	125	36	epidemiology	epidemiology	NN
cord-017337-vq3edhxn	125	37	of	of	IN
cord-017337-vq3edhxn	125	38	sepsis	sepsis	NN
cord-017337-vq3edhxn	125	39	.	.	.
cord-017337-vq3edhxn	126	1	Importantly	importantly	RB
cord-017337-vq3edhxn	126	2	,	,	,
cord-017337-vq3edhxn	126	3	just	just	RB
cord-017337-vq3edhxn	126	4	as	as	IN
cord-017337-vq3edhxn	126	5	the	the	DT
cord-017337-vq3edhxn	126	6	TNM	TNM	NNP
cord-017337-vq3edhxn	126	7	system	system	NN
cord-017337-vq3edhxn	126	8	is	be	VBZ
cord-017337-vq3edhxn	126	9	adjusted	adjust	VBN
cord-017337-vq3edhxn	126	10	to	to	IN
cord-017337-vq3edhxn	126	11	specifi	specifi	NN
cord-017337-vq3edhxn	126	12	c	c	NN
cord-017337-vq3edhxn	126	13	cancers	cancer	NNS
cord-017337-vq3edhxn	126	14	[	[	-LRB-
cord-017337-vq3edhxn	126	15	33	33	CD
cord-017337-vq3edhxn	126	16	]	]	-RRB-
cord-017337-vq3edhxn	126	17	,	,	,
cord-017337-vq3edhxn	126	18	so	so	CC
cord-017337-vq3edhxn	126	19	the	the	DT
cord-017337-vq3edhxn	126	20	PIRO	PIRO	NNP
cord-017337-vq3edhxn	126	21	system	system	NN
cord-017337-vq3edhxn	126	22	will	will	MD
cord-017337-vq3edhxn	126	23	need	need	VB
cord-017337-vq3edhxn	126	24	to	to	TO
cord-017337-vq3edhxn	126	25	be	be	VB
cord-017337-vq3edhxn	126	26	adapted	adapt	VBN
cord-017337-vq3edhxn	126	27	to	to	IN
cord-017337-vq3edhxn	126	28	fi	fi	NNP
cord-017337-vq3edhxn	126	29	t	t	NNP
cord-017337-vq3edhxn	126	30	specifi	specifi	NNP
cord-017337-vq3edhxn	126	31	c	c	NNP
cord-017337-vq3edhxn	126	32	patient	patient	NN
cord-017337-vq3edhxn	126	33	1	1	CD
cord-017337-vq3edhxn	126	34	groups	group	NNS
cord-017337-vq3edhxn	126	35	,	,	,
cord-017337-vq3edhxn	126	36	local	local	JJ
cord-017337-vq3edhxn	126	37	practice	practice	NN
cord-017337-vq3edhxn	126	38	,	,	,
cord-017337-vq3edhxn	126	39	purpose	purpose	NN
cord-017337-vq3edhxn	126	40	(	(	-LRB-
cord-017337-vq3edhxn	126	41	e.g.	e.g.	RB
cord-017337-vq3edhxn	126	42	,	,	,
cord-017337-vq3edhxn	126	43	clinical	clinical	JJ
cord-017337-vq3edhxn	126	44	trial	trial	NN
cord-017337-vq3edhxn	126	45	inclusion	inclusion	NN
cord-017337-vq3edhxn	126	46	,	,	,
cord-017337-vq3edhxn	126	47	prognostication	prognostication	NN
cord-017337-vq3edhxn	126	48	,	,	,
cord-017337-vq3edhxn	126	49	patient	patient	JJ
cord-017337-vq3edhxn	126	50	management	management	NN
cord-017337-vq3edhxn	126	51	)	)	-RRB-
cord-017337-vq3edhxn	126	52	,	,	,
cord-017337-vq3edhxn	126	53	or	or	CC
cord-017337-vq3edhxn	126	54	proposed	propose	VBN
cord-017337-vq3edhxn	126	55	therapies	therapy	NNS
cord-017337-vq3edhxn	126	56	.	.	.
cord-017337-vq3edhxn	127	1	For	for	IN
cord-017337-vq3edhxn	127	2	example	example	NN
cord-017337-vq3edhxn	127	3	,	,	,
cord-017337-vq3edhxn	127	4	if	if	IN
cord-017337-vq3edhxn	127	5	the	the	DT
cord-017337-vq3edhxn	127	6	planned	plan	VBN
cord-017337-vq3edhxn	127	7	intervention	intervention	NN
cord-017337-vq3edhxn	127	8	is	be	VBZ
cord-017337-vq3edhxn	127	9	an	an	DT
cord-017337-vq3edhxn	127	10	anticoagulant	anticoagulant	NN
cord-017337-vq3edhxn	127	11	then	then	RB
cord-017337-vq3edhxn	127	12	evidence	evidence	NN
cord-017337-vq3edhxn	127	13	of	of	IN
cord-017337-vq3edhxn	127	14	coagulopathy	coagulopathy	NN
cord-017337-vq3edhxn	127	15	is	be	VBZ
cord-017337-vq3edhxn	127	16	likely	likely	JJ
cord-017337-vq3edhxn	127	17	to	to	TO
cord-017337-vq3edhxn	127	18	be	be	VB
cord-017337-vq3edhxn	127	19	more	more	RBR
cord-017337-vq3edhxn	127	20	relevant	relevant	JJ
cord-017337-vq3edhxn	127	21	than	than	IN
cord-017337-vq3edhxn	127	22	presence	presence	NN
cord-017337-vq3edhxn	127	23	of	of	IN
cord-017337-vq3edhxn	127	24	respiratory	respiratory	JJ
cord-017337-vq3edhxn	127	25	failure	failure	NN
cord-017337-vq3edhxn	127	26	,	,	,
cord-017337-vq3edhxn	127	27	while	while	IN
cord-017337-vq3edhxn	127	28	if	if	IN
cord-017337-vq3edhxn	127	29	considering	consider	VBG
cord-017337-vq3edhxn	127	30	hemodialysis	hemodialysis	NN
cord-017337-vq3edhxn	127	31	,	,	,
cord-017337-vq3edhxn	127	32	the	the	DT
cord-017337-vq3edhxn	127	33	presence	presence	NN
cord-017337-vq3edhxn	127	34	and	and	CC
cord-017337-vq3edhxn	127	35	degree	degree	NN
cord-017337-vq3edhxn	127	36	of	of	IN
cord-017337-vq3edhxn	127	37	renal	renal	JJ
cord-017337-vq3edhxn	127	38	failure	failure	NN
cord-017337-vq3edhxn	127	39	are	be	VBP
cord-017337-vq3edhxn	127	40	likely	likely	JJ
cord-017337-vq3edhxn	127	41	to	to	TO
cord-017337-vq3edhxn	127	42	be	be	VB
cord-017337-vq3edhxn	127	43	most	most	RBS
cord-017337-vq3edhxn	127	44	pertinent	pertinent	JJ
cord-017337-vq3edhxn	127	45	[	[	-LRB-
cord-017337-vq3edhxn	127	46	24	24	CD
cord-017337-vq3edhxn	127	47	]	]	-RRB-
cord-017337-vq3edhxn	127	48	.	.	.
cord-017337-vq3edhxn	128	1	However	however	RB
cord-017337-vq3edhxn	128	2	,	,	,
cord-017337-vq3edhxn	128	3	despite	despite	IN
cord-017337-vq3edhxn	128	4	general	general	JJ
cord-017337-vq3edhxn	128	5	acceptance	acceptance	NN
cord-017337-vq3edhxn	128	6	of	of	IN
cord-017337-vq3edhxn	128	7	the	the	DT
cord-017337-vq3edhxn	128	8	PIRO	PIRO	NNP
cord-017337-vq3edhxn	128	9	concept	concept	NN
cord-017337-vq3edhxn	128	10	and	and	CC
cord-017337-vq3edhxn	128	11	belief	belief	NN
cord-017337-vq3edhxn	128	12	that	that	IN
cord-017337-vq3edhxn	128	13	it	-PRON-	PRP
cord-017337-vq3edhxn	128	14	may	may	MD
cord-017337-vq3edhxn	128	15	contribute	contribute	VB
cord-017337-vq3edhxn	128	16	to	to	IN
cord-017337-vq3edhxn	128	17	improving	improve	VBG
cord-017337-vq3edhxn	128	18	outcomes	outcome	NNS
cord-017337-vq3edhxn	128	19	in	in	IN
cord-017337-vq3edhxn	128	20	patients	patient	NNS
cord-017337-vq3edhxn	128	21	with	with	IN
cord-017337-vq3edhxn	128	22	sepsis	sepsis	NN
cord-017337-vq3edhxn	128	23	,	,	,
cord-017337-vq3edhxn	128	24	many	many	JJ
cord-017337-vq3edhxn	128	25	questions	question	NNS
cord-017337-vq3edhxn	128	26	remain	remain	VBP
cord-017337-vq3edhxn	128	27	unanswered	unanswered	JJ
cord-017337-vq3edhxn	128	28	.	.	.
cord-017337-vq3edhxn	129	1	For	for	IN
cord-017337-vq3edhxn	129	2	example	example	NN
cord-017337-vq3edhxn	129	3	,	,	,
cord-017337-vq3edhxn	129	4	in	in	IN
cord-017337-vq3edhxn	129	5	patients	patient	NNS
cord-017337-vq3edhxn	129	6	with	with	IN
cord-017337-vq3edhxn	129	7	cancer	cancer	NN
cord-017337-vq3edhxn	129	8	,	,	,
cord-017337-vq3edhxn	129	9	correct	correct	JJ
cord-017337-vq3edhxn	129	10	staging	staging	NN
cord-017337-vq3edhxn	129	11	is	be	VBZ
cord-017337-vq3edhxn	129	12	critical	critical	JJ
cord-017337-vq3edhxn	129	13	because	because	IN
cord-017337-vq3edhxn	129	14	treatment	treatment	NN
cord-017337-vq3edhxn	129	15	is	be	VBZ
cord-017337-vq3edhxn	129	16	directly	directly	RB
cord-017337-vq3edhxn	129	17	related	relate	VBN
cord-017337-vq3edhxn	129	18	to	to	IN
cord-017337-vq3edhxn	129	19	disease	disease	NN
cord-017337-vq3edhxn	129	20	stage	stage	NN
cord-017337-vq3edhxn	129	21	.	.	.
cord-017337-vq3edhxn	130	1	Thus	thus	RB
cord-017337-vq3edhxn	130	2	,	,	,
cord-017337-vq3edhxn	130	3	incorrect	incorrect	JJ
cord-017337-vq3edhxn	130	4	staging	staging	NN
cord-017337-vq3edhxn	130	5	can	can	MD
cord-017337-vq3edhxn	130	6	lead	lead	VB
cord-017337-vq3edhxn	130	7	to	to	IN
cord-017337-vq3edhxn	130	8	improper	improper	JJ
cord-017337-vq3edhxn	130	9	treatment	treatment	NN
cord-017337-vq3edhxn	130	10	and	and	CC
cord-017337-vq3edhxn	130	11	to	to	IN
cord-017337-vq3edhxn	130	12	reduced	reduce	VBN
cord-017337-vq3edhxn	130	13	patient	patient	JJ
cord-017337-vq3edhxn	130	14	outcomes	outcome	NNS
cord-017337-vq3edhxn	130	15	.	.	.
cord-017337-vq3edhxn	131	1	Whether	whether	IN
cord-017337-vq3edhxn	131	2	the	the	DT
cord-017337-vq3edhxn	131	3	same	same	JJ
cord-017337-vq3edhxn	131	4	would	would	MD
cord-017337-vq3edhxn	131	5	hold	hold	VB
cord-017337-vq3edhxn	131	6	true	true	JJ
cord-017337-vq3edhxn	131	7	for	for	IN
cord-017337-vq3edhxn	131	8	patients	patient	NNS
cord-017337-vq3edhxn	131	9	with	with	IN
cord-017337-vq3edhxn	131	10	sepsis	sepsis	NN
cord-017337-vq3edhxn	131	11	is	be	VBZ
cord-017337-vq3edhxn	131	12	unknown	unknown	JJ
cord-017337-vq3edhxn	131	13	.	.	.
cord-017337-vq3edhxn	132	1	Clearly	clearly	RB
cord-017337-vq3edhxn	132	2	,	,	,
cord-017337-vq3edhxn	132	3	considerable	considerable	JJ
cord-017337-vq3edhxn	132	4	work	work	NN
cord-017337-vq3edhxn	132	5	remains	remain	VBZ
cord-017337-vq3edhxn	132	6	to	to	TO
cord-017337-vq3edhxn	132	7	be	be	VB
cord-017337-vq3edhxn	132	8	done	do	VBN
cord-017337-vq3edhxn	132	9	in	in	IN
cord-017337-vq3edhxn	132	10	testing	testing	NN
cord-017337-vq3edhxn	132	11	and	and	CC
cord-017337-vq3edhxn	132	12	validating	validate	VBG
cord-017337-vq3edhxn	132	13	the	the	DT
cord-017337-vq3edhxn	132	14	PIRO	PIRO	NNP
cord-017337-vq3edhxn	132	15	system	system	NN
cord-017337-vq3edhxn	132	16	,	,	,
cord-017337-vq3edhxn	132	17	but	but	CC
cord-017337-vq3edhxn	132	18	it	-PRON-	PRP
cord-017337-vq3edhxn	132	19	represents	represent	VBZ
cord-017337-vq3edhxn	132	20	an	an	DT
cord-017337-vq3edhxn	132	21	important	important	JJ
cord-017337-vq3edhxn	132	22	step	step	NN
cord-017337-vq3edhxn	132	23	toward	toward	IN
cord-017337-vq3edhxn	132	24	more	more	RBR
cord-017337-vq3edhxn	132	25	successful	successful	JJ
cord-017337-vq3edhxn	132	26	management	management	NN
cord-017337-vq3edhxn	132	27	of	of	IN
cord-017337-vq3edhxn	132	28	the	the	DT
cord-017337-vq3edhxn	132	29	patient	patient	NN
cord-017337-vq3edhxn	132	30	with	with	IN
cord-017337-vq3edhxn	132	31	severe	severe	JJ
cord-017337-vq3edhxn	132	32	sepsis	sepsis	NN
cord-017337-vq3edhxn	132	33	.	.	.
cord-017337-vq3edhxn	133	1	Defi	Defi	NNP
cord-017337-vq3edhxn	133	2	nitions	nition	NNS
cord-017337-vq3edhxn	133	3	of	of	IN
cord-017337-vq3edhxn	133	4	sepsis	sepsis	NN
cord-017337-vq3edhxn	133	5	and	and	CC
cord-017337-vq3edhxn	133	6	multiple	multiple	JJ
cord-017337-vq3edhxn	133	7	organ	organ	NN
cord-017337-vq3edhxn	133	8	failure	failure	NN
cord-017337-vq3edhxn	133	9	and	and	CC
cord-017337-vq3edhxn	133	10	guidelines	guideline	NNS
cord-017337-vq3edhxn	133	11	for	for	IN
cord-017337-vq3edhxn	133	12	the	the	DT
cord-017337-vq3edhxn	133	13	use	use	NN
cord-017337-vq3edhxn	133	14	of	of	IN
cord-017337-vq3edhxn	133	15	innovative	innovative	JJ
cord-017337-vq3edhxn	133	16	therapies	therapy	NNS
cord-017337-vq3edhxn	133	17	in	in	IN
cord-017337-vq3edhxn	133	18	sepsis	sepsis	NN
cord-017337-vq3edhxn	134	1	Systemic	systemic	JJ
cord-017337-vq3edhxn	134	2	infl	infl	XX
cord-017337-vq3edhxn	134	3	ammatory	ammatory	NNP
cord-017337-vq3edhxn	134	4	response	response	NN
cord-017337-vq3edhxn	134	5	syndrome	syndrome	NN
cord-017337-vq3edhxn	134	6	,	,	,
cord-017337-vq3edhxn	134	7	sepsis	sepsis	NN
cord-017337-vq3edhxn	134	8	,	,	,
cord-017337-vq3edhxn	134	9	severe	severe	JJ
cord-017337-vq3edhxn	134	10	sepsis	sepsis	NN
cord-017337-vq3edhxn	134	11	and	and	CC
cord-017337-vq3edhxn	134	12	septic	septic	JJ
cord-017337-vq3edhxn	134	13	shock	shock	NN
cord-017337-vq3edhxn	134	14	:	:	:
cord-017337-vq3edhxn	134	15	incidence	incidence	NN
cord-017337-vq3edhxn	134	16	,	,	,
cord-017337-vq3edhxn	134	17	morbidities	morbidity	NNS
cord-017337-vq3edhxn	134	18	and	and	CC
cord-017337-vq3edhxn	134	19	outcomes	outcome	NNS
cord-017337-vq3edhxn	134	20	in	in	IN
cord-017337-vq3edhxn	134	21	surgical	surgical	JJ
cord-017337-vq3edhxn	134	22	ICU	ICU	NNP
cord-017337-vq3edhxn	134	23	patients	patient	NNS
cord-017337-vq3edhxn	135	1	The	the	DT
cord-017337-vq3edhxn	135	2	Italian	italian	JJ
cord-017337-vq3edhxn	135	3	SEPSIS	SEPSIS	NNP
cord-017337-vq3edhxn	135	4	study	study	NN
cord-017337-vq3edhxn	135	5	:	:	:
cord-017337-vq3edhxn	136	1	Preliminary	preliminary	JJ
cord-017337-vq3edhxn	136	2	results	result	NNS
cord-017337-vq3edhxn	136	3	on	on	IN
cord-017337-vq3edhxn	136	4	the	the	DT
cord-017337-vq3edhxn	136	5	incidence	incidence	NN
cord-017337-vq3edhxn	136	6	and	and	CC
cord-017337-vq3edhxn	136	7	evolution	evolution	NN
cord-017337-vq3edhxn	136	8	of	of	IN
cord-017337-vq3edhxn	136	9	SIRS	sirs	NN
cord-017337-vq3edhxn	136	10	,	,	,
cord-017337-vq3edhxn	136	11	sepsis	sepsis	NN
cord-017337-vq3edhxn	136	12	,	,	,
cord-017337-vq3edhxn	136	13	severe	severe	JJ
cord-017337-vq3edhxn	136	14	sepsis	sepsis	NN
cord-017337-vq3edhxn	136	15	and	and	CC
cord-017337-vq3edhxn	136	16	septic	septic	JJ
cord-017337-vq3edhxn	136	17	shock	shock	NN
cord-017337-vq3edhxn	137	1	Dear	dear	JJ
cord-017337-vq3edhxn	137	2	Sirs	sirs	UH
cord-017337-vq3edhxn	137	3	,	,	,
cord-017337-vq3edhxn	137	4	I	-PRON-	PRP
cord-017337-vq3edhxn	137	5	'm	be	VBP
cord-017337-vq3edhxn	137	6	sorry	sorry	JJ
cord-017337-vq3edhxn	137	7	to	to	TO
cord-017337-vq3edhxn	137	8	say	say	VB
cord-017337-vq3edhxn	137	9	that	that	IN
cord-017337-vq3edhxn	137	10	I	-PRON-	PRP
cord-017337-vq3edhxn	137	11	do	do	VBP
cord-017337-vq3edhxn	137	12	n't	not	RB
cord-017337-vq3edhxn	137	13	like	like	VB
cord-017337-vq3edhxn	137	14	you	-PRON-	PRP
cord-017337-vq3edhxn	138	1	SCCM	SCCM	NNP
cord-017337-vq3edhxn	138	2	/	/	SYM
cord-017337-vq3edhxn	138	3	ESICM	ESICM	NNP
cord-017337-vq3edhxn	138	4	/	/	SYM
cord-017337-vq3edhxn	138	5	ACCP	ACCP	NNP
cord-017337-vq3edhxn	138	6	/	/	SYM
cord-017337-vq3edhxn	138	7	ATS/	ATS/	NNP
cord-017337-vq3edhxn	139	1	SIS	SIS	NNP
cord-017337-vq3edhxn	139	2	International	International	NNP
cord-017337-vq3edhxn	139	3	Sepsis	Sepsis	NNP
cord-017337-vq3edhxn	139	4	Defi	Defi	NNP
cord-017337-vq3edhxn	139	5	nitions	nition	NNS
cord-017337-vq3edhxn	139	6	Conference	Conference	NNP
cord-017337-vq3edhxn	139	7	Measures	measure	NNS
cord-017337-vq3edhxn	139	8	,	,	,
cord-017337-vq3edhxn	139	9	markers	marker	NNS
cord-017337-vq3edhxn	139	10	,	,	,
cord-017337-vq3edhxn	139	11	and	and	CC
cord-017337-vq3edhxn	139	12	mediators	mediator	NNS
cord-017337-vq3edhxn	139	13	:	:	:
cord-017337-vq3edhxn	139	14	toward	toward	IN
cord-017337-vq3edhxn	139	15	a	a	DT
cord-017337-vq3edhxn	139	16	staging	staging	NN
cord-017337-vq3edhxn	139	17	system	system	NN
cord-017337-vq3edhxn	139	18	for	for	IN
cord-017337-vq3edhxn	139	19	clinical	clinical	JJ
cord-017337-vq3edhxn	139	20	sepsis	sepsis	NN
cord-017337-vq3edhxn	139	21	.	.	.
cord-017337-vq3edhxn	140	1	A	a	DT
cord-017337-vq3edhxn	140	2	report	report	NN
cord-017337-vq3edhxn	140	3	of	of	IN
cord-017337-vq3edhxn	140	4	the	the	DT
cord-017337-vq3edhxn	140	5	Fifth	Fifth	NNP
cord-017337-vq3edhxn	140	6	Toronto	Toronto	NNP
cord-017337-vq3edhxn	140	7	Sepsis	Sepsis	NNP
cord-017337-vq3edhxn	140	8	Roundtable	Roundtable	NNP
cord-017337-vq3edhxn	140	9	Enquete	Enquete	NNP
cord-017337-vq3edhxn	140	10	permanent	permanent	JJ
cord-017337-vq3edhxn	140	11	dans	dans	FW
cord-017337-vq3edhxn	140	12	les	les	FW
cord-017337-vq3edhxn	140	13	centres	centre	NNS
cord-017337-vq3edhxn	140	14	anticancereaux	anticancereaux	RB
cord-017337-vq3edhxn	141	1	The	the	DT
cord-017337-vq3edhxn	141	2	PIRO	PIRO	NNP
cord-017337-vq3edhxn	141	3	concept	concept	NN
cord-017337-vq3edhxn	141	4	:	:	:
cord-017337-vq3edhxn	141	5	P	p	NN
cord-017337-vq3edhxn	141	6	is	be	VBZ
cord-017337-vq3edhxn	141	7	for	for	IN
cord-017337-vq3edhxn	141	8	predisposition	predisposition	NN
cord-017337-vq3edhxn	141	9	Injury	injury	NN
cord-017337-vq3edhxn	141	10	research	research	NN
cord-017337-vq3edhxn	141	11	in	in	IN
cord-017337-vq3edhxn	141	12	the	the	DT
cord-017337-vq3edhxn	141	13	genomic	genomic	JJ
cord-017337-vq3edhxn	141	14	era	era	NN
cord-017337-vq3edhxn	141	15	Association	Association	NNP
cord-017337-vq3edhxn	141	16	of	of	IN
cord-017337-vq3edhxn	141	17	TNF2	TNF2	NNP
cord-017337-vq3edhxn	141	18	,	,	,
cord-017337-vq3edhxn	141	19	a	a	DT
cord-017337-vq3edhxn	141	20	TNFα	tnfα	NN
cord-017337-vq3edhxn	141	21	promoter	promoter	NN
cord-017337-vq3edhxn	141	22	polymorphism	polymorphism	NN
cord-017337-vq3edhxn	141	23	,	,	,
cord-017337-vq3edhxn	141	24	with	with	IN
cord-017337-vq3edhxn	141	25	plasma	plasma	NN
cord-017337-vq3edhxn	141	26	TNFα	TNFα	NNS
cord-017337-vq3edhxn	141	27	levels	level	NNS
cord-017337-vq3edhxn	141	28	and	and	CC
cord-017337-vq3edhxn	141	29	mortality	mortality	NN
cord-017337-vq3edhxn	141	30	in	in	IN
cord-017337-vq3edhxn	141	31	septic	septic	JJ
cord-017337-vq3edhxn	141	32	shock	shock	NN
cord-017337-vq3edhxn	141	33	Interleukin-1	Interleukin-1	NNP
cord-017337-vq3edhxn	141	34	receptor	receptor	NN
cord-017337-vq3edhxn	141	35	antagonist	antagonist	NN
cord-017337-vq3edhxn	141	36	gene	gene	NN
cord-017337-vq3edhxn	141	37	polymorphism	polymorphism	NN
cord-017337-vq3edhxn	141	38	and	and	CC
cord-017337-vq3edhxn	141	39	mortality	mortality	NN
cord-017337-vq3edhxn	141	40	in	in	IN
cord-017337-vq3edhxn	141	41	patients	patient	NNS
cord-017337-vq3edhxn	141	42	with	with	IN
cord-017337-vq3edhxn	141	43	severe	severe	JJ
cord-017337-vq3edhxn	141	44	sepsis	sepsis	NN
cord-017337-vq3edhxn	142	1	Toll	toll	NN
cord-017337-vq3edhxn	142	2	-	-	HYPH
cord-017337-vq3edhxn	142	3	like	like	JJ
cord-017337-vq3edhxn	142	4	receptor	receptor	NN
cord-017337-vq3edhxn	142	5	1	1	CD
cord-017337-vq3edhxn	142	6	polymorphisms	polymorphism	NNS
cord-017337-vq3edhxn	142	7	affect	affect	VBP
cord-017337-vq3edhxn	142	8	innate	innate	JJ
cord-017337-vq3edhxn	142	9	immune	immune	JJ
cord-017337-vq3edhxn	142	10	responses	response	NNS
cord-017337-vq3edhxn	142	11	and	and	CC
cord-017337-vq3edhxn	142	12	outcomes	outcome	NNS
cord-017337-vq3edhxn	142	13	in	in	IN
cord-017337-vq3edhxn	142	14	sepsis	sepsis	NN
cord-017337-vq3edhxn	142	15	Incidence	incidence	NN
cord-017337-vq3edhxn	142	16	and	and	CC
cord-017337-vq3edhxn	142	17	mortality	mortality	NN
cord-017337-vq3edhxn	142	18	of	of	IN
cord-017337-vq3edhxn	142	19	severe	severe	JJ
cord-017337-vq3edhxn	142	20	sepsis	sepsis	NN
cord-017337-vq3edhxn	142	21	in	in	IN
cord-017337-vq3edhxn	142	22	surgical	surgical	JJ
cord-017337-vq3edhxn	142	23	intensive	intensive	JJ
cord-017337-vq3edhxn	142	24	care	care	NN
cord-017337-vq3edhxn	142	25	patients	patient	NNS
cord-017337-vq3edhxn	142	26	:	:	:
cord-017337-vq3edhxn	142	27	the	the	DT
cord-017337-vq3edhxn	142	28	infl	infl	NN
cord-017337-vq3edhxn	142	29	uence	uence	NN
cord-017337-vq3edhxn	142	30	of	of	IN
cord-017337-vq3edhxn	142	31	patient	patient	JJ
cord-017337-vq3edhxn	142	32	gender	gender	NN
cord-017337-vq3edhxn	142	33	on	on	IN
cord-017337-vq3edhxn	142	34	disease	disease	NN
cord-017337-vq3edhxn	142	35	process	process	NN
cord-017337-vq3edhxn	142	36	and	and	CC
cord-017337-vq3edhxn	142	37	outcome	outcome	NN
cord-017337-vq3edhxn	143	1	The	the	DT
cord-017337-vq3edhxn	143	2	epidemiology	epidemiology	NN
cord-017337-vq3edhxn	143	3	of	of	IN
cord-017337-vq3edhxn	143	4	sepsis	sepsis	NN
cord-017337-vq3edhxn	143	5	in	in	IN
cord-017337-vq3edhxn	143	6	the	the	DT
cord-017337-vq3edhxn	143	7	United	United	NNP
cord-017337-vq3edhxn	143	8	States	States	NNP
cord-017337-vq3edhxn	143	9	from	from	IN
cord-017337-vq3edhxn	143	10	1979	1979	CD
cord-017337-vq3edhxn	143	11	through	through	IN
cord-017337-vq3edhxn	143	12	2000	2000	CD
cord-017337-vq3edhxn	143	13	Effect	effect	NN
cord-017337-vq3edhxn	143	14	of	of	IN
cord-017337-vq3edhxn	143	15	patient	patient	JJ
cord-017337-vq3edhxn	143	16	sex	sex	NN
cord-017337-vq3edhxn	143	17	on	on	IN
cord-017337-vq3edhxn	143	18	intensive	intensive	JJ
cord-017337-vq3edhxn	143	19	care	care	NN
cord-017337-vq3edhxn	143	20	unit	unit	NN
cord-017337-vq3edhxn	143	21	survival	survival	NN
cord-017337-vq3edhxn	143	22	Sepsis	sepsis	NN
cord-017337-vq3edhxn	143	23	in	in	IN
cord-017337-vq3edhxn	143	24	European	european	JJ
cord-017337-vq3edhxn	143	25	intensive	intensive	JJ
cord-017337-vq3edhxn	143	26	care	care	NN
cord-017337-vq3edhxn	143	27	units	unit	NNS
cord-017337-vq3edhxn	143	28	:	:	:
cord-017337-vq3edhxn	143	29	results	result	NNS
cord-017337-vq3edhxn	143	30	of	of	IN
cord-017337-vq3edhxn	143	31	the	the	DT
cord-017337-vq3edhxn	143	32	SOAP	soap	NN
cord-017337-vq3edhxn	143	33	study	study	NN
cord-017337-vq3edhxn	143	34	Racial	racial	JJ
cord-017337-vq3edhxn	143	35	variation	variation	NN
cord-017337-vq3edhxn	143	36	in	in	IN
cord-017337-vq3edhxn	143	37	the	the	DT
cord-017337-vq3edhxn	143	38	incidence	incidence	NN
cord-017337-vq3edhxn	143	39	,	,	,
cord-017337-vq3edhxn	143	40	care	care	NN
cord-017337-vq3edhxn	143	41	,	,	,
cord-017337-vq3edhxn	143	42	and	and	CC
cord-017337-vq3edhxn	143	43	outcomes	outcome	NNS
cord-017337-vq3edhxn	143	44	of	of	IN
cord-017337-vq3edhxn	143	45	severe	severe	JJ
cord-017337-vq3edhxn	143	46	sepsis	sepsis	NN
cord-017337-vq3edhxn	143	47	:	:	:
cord-017337-vq3edhxn	143	48	analysis	analysis	NN
cord-017337-vq3edhxn	143	49	of	of	IN
cord-017337-vq3edhxn	143	50	population	population	NN
cord-017337-vq3edhxn	143	51	,	,	,
cord-017337-vq3edhxn	143	52	patient	patient	JJ
cord-017337-vq3edhxn	143	53	,	,	,
cord-017337-vq3edhxn	143	54	and	and	CC
cord-017337-vq3edhxn	143	55	hospital	hospital	NN
cord-017337-vq3edhxn	143	56	characteristics	characteristic	NNS
cord-017337-vq3edhxn	144	1	The	the	DT
cord-017337-vq3edhxn	144	2	effect	effect	NN
cord-017337-vq3edhxn	144	3	of	of	IN
cord-017337-vq3edhxn	144	4	age	age	NN
cord-017337-vq3edhxn	144	5	on	on	IN
cord-017337-vq3edhxn	144	6	the	the	DT
cord-017337-vq3edhxn	144	7	development	development	NN
cord-017337-vq3edhxn	144	8	and	and	CC
cord-017337-vq3edhxn	144	9	outcome	outcome	NN
cord-017337-vq3edhxn	144	10	of	of	IN
cord-017337-vq3edhxn	144	11	adult	adult	NN
cord-017337-vq3edhxn	144	12	sepsis	sepsis	NN
cord-017337-vq3edhxn	145	1	The	the	DT
cord-017337-vq3edhxn	145	2	PIRO	PIRO	NNP
cord-017337-vq3edhxn	145	3	concept	concept	NN
cord-017337-vq3edhxn	145	4	:	:	:
cord-017337-vq3edhxn	145	5	I	-PRON-	PRP
cord-017337-vq3edhxn	145	6	is	be	VBZ
cord-017337-vq3edhxn	145	7	for	for	IN
cord-017337-vq3edhxn	145	8	infection	infection	NN
cord-017337-vq3edhxn	145	9	Effi	Effi	NNP
cord-017337-vq3edhxn	145	10	cacy	cacy	NN
cord-017337-vq3edhxn	145	11	and	and	CC
cord-017337-vq3edhxn	145	12	safety	safety	NN
cord-017337-vq3edhxn	145	13	of	of	IN
cord-017337-vq3edhxn	145	14	recombinant	recombinant	JJ
cord-017337-vq3edhxn	145	15	human	human	NN
cord-017337-vq3edhxn	145	16	activated	activate	VBN
cord-017337-vq3edhxn	145	17	protein	protein	NN
cord-017337-vq3edhxn	145	18	C	c	NN
cord-017337-vq3edhxn	145	19	for	for	IN
cord-017337-vq3edhxn	145	20	severe	severe	JJ
cord-017337-vq3edhxn	145	21	sepsis	sepsis	NN
cord-017337-vq3edhxn	145	22	Epidemiology	epidemiology	NN
cord-017337-vq3edhxn	145	23	of	of	IN
cord-017337-vq3edhxn	145	24	severe	severe	JJ
cord-017337-vq3edhxn	145	25	sepsis	sepsis	NN
cord-017337-vq3edhxn	145	26	in	in	IN
cord-017337-vq3edhxn	145	27	critically	critically	RB
cord-017337-vq3edhxn	145	28	ill	ill	JJ
cord-017337-vq3edhxn	145	29	surgical	surgical	JJ
cord-017337-vq3edhxn	145	30	patients	patient	NNS
cord-017337-vq3edhxn	145	31	in	in	IN
cord-017337-vq3edhxn	145	32	ten	ten	CD
cord-017337-vq3edhxn	145	33	university	university	NN
cord-017337-vq3edhxn	145	34	hospitals	hospital	NNS
cord-017337-vq3edhxn	145	35	in	in	IN
cord-017337-vq3edhxn	145	36	China	China	NNP
cord-017337-vq3edhxn	146	1	New	new	JJ
cord-017337-vq3edhxn	146	2	method	method	NN
cord-017337-vq3edhxn	146	3	of	of	IN
cord-017337-vq3edhxn	146	4	classifying	classify	VBG
cord-017337-vq3edhxn	146	5	infections	infection	NNS
cord-017337-vq3edhxn	146	6	in	in	IN
cord-017337-vq3edhxn	146	7	critically	critically	RB
cord-017337-vq3edhxn	146	8	ill	ill	JJ
cord-017337-vq3edhxn	146	9	patients	patient	NNS
cord-017337-vq3edhxn	146	10	Septic	septic	JJ
cord-017337-vq3edhxn	146	11	shock	shock	NN
cord-017337-vq3edhxn	146	12	of	of	IN
cord-017337-vq3edhxn	146	13	early	early	JJ
cord-017337-vq3edhxn	146	14	or	or	CC
cord-017337-vq3edhxn	146	15	late	late	JJ
cord-017337-vq3edhxn	146	16	onset	onset	NN
cord-017337-vq3edhxn	146	17	:	:	:
cord-017337-vq3edhxn	146	18	does	do	VBZ
cord-017337-vq3edhxn	146	19	it	-PRON-	PRP
cord-017337-vq3edhxn	146	20	matter	matter	VB
cord-017337-vq3edhxn	146	21	?	?	.
cord-017337-vq3edhxn	147	1	The	the	DT
cord-017337-vq3edhxn	147	2	PIRO	PIRO	NNP
cord-017337-vq3edhxn	147	3	Concept	Concept	NNP
cord-017337-vq3edhxn	147	4	:	:	:
cord-017337-vq3edhxn	147	5	R	r	NN
cord-017337-vq3edhxn	147	6	is	be	VBZ
cord-017337-vq3edhxn	147	7	for	for	IN
cord-017337-vq3edhxn	147	8	response	response	NN
cord-017337-vq3edhxn	148	1	Monocyte	Monocyte	NNP
cord-017337-vq3edhxn	148	2	deactivation	deactivation	NN
cord-017337-vq3edhxn	148	3	-rationale	-rationale	NN
cord-017337-vq3edhxn	148	4	for	for	IN
cord-017337-vq3edhxn	148	5	a	a	DT
cord-017337-vq3edhxn	148	6	new	new	JJ
cord-017337-vq3edhxn	148	7	therapeutic	therapeutic	JJ
cord-017337-vq3edhxn	148	8	strategy	strategy	NN
cord-017337-vq3edhxn	148	9	in	in	IN
cord-017337-vq3edhxn	148	10	sepsis	sepsis	NN
cord-017337-vq3edhxn	149	1	The	the	DT
cord-017337-vq3edhxn	149	2	PIRO	PIRO	NNP
cord-017337-vq3edhxn	149	3	concept	concept	NN
cord-017337-vq3edhxn	149	4	:	:	:
cord-017337-vq3edhxn	149	5	O	o	UH
cord-017337-vq3edhxn	149	6	is	be	VBZ
cord-017337-vq3edhxn	149	7	for	for	IN
cord-017337-vq3edhxn	149	8	organ	organ	NN
cord-017337-vq3edhxn	149	9	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	149	10	Use	Use	NNP
cord-017337-vq3edhxn	149	11	of	of	IN
cord-017337-vq3edhxn	149	12	the	the	DT
cord-017337-vq3edhxn	149	13	SOFA	sofa	NN
cord-017337-vq3edhxn	149	14	score	score	NN
cord-017337-vq3edhxn	149	15	to	to	TO
cord-017337-vq3edhxn	149	16	assess	assess	VB
cord-017337-vq3edhxn	149	17	the	the	DT
cord-017337-vq3edhxn	149	18	incidence	incidence	NN
cord-017337-vq3edhxn	149	19	of	of	IN
cord-017337-vq3edhxn	149	20	organ	organ	NN
cord-017337-vq3edhxn	149	21	dysfunction	dysfunction	NN
cord-017337-vq3edhxn	149	22	/	/	SYM
cord-017337-vq3edhxn	149	23	failure	failure	NN
cord-017337-vq3edhxn	149	24	in	in	IN
cord-017337-vq3edhxn	149	25	intensive	intensive	JJ
cord-017337-vq3edhxn	149	26	care	care	NN
cord-017337-vq3edhxn	149	27	units	unit	NNS
cord-017337-vq3edhxn	149	28	:	:	:
cord-017337-vq3edhxn	149	29	Results	result	NNS
cord-017337-vq3edhxn	149	30	of	of	IN
cord-017337-vq3edhxn	149	31	a	a	DT
cord-017337-vq3edhxn	149	32	multicentric	multicentric	NN
cord-017337-vq3edhxn	149	33	,	,	,
cord-017337-vq3edhxn	149	34	prospective	prospective	JJ
cord-017337-vq3edhxn	149	35	study	study	NN
cord-017337-vq3edhxn	149	36	Serial	serial	JJ
cord-017337-vq3edhxn	149	37	evaluation	evaluation	NN
cord-017337-vq3edhxn	149	38	of	of	IN
cord-017337-vq3edhxn	149	39	the	the	DT
cord-017337-vq3edhxn	149	40	SOFA	sofa	NN
cord-017337-vq3edhxn	149	41	score	score	NN
cord-017337-vq3edhxn	149	42	to	to	TO
cord-017337-vq3edhxn	149	43	predict	predict	VB
cord-017337-vq3edhxn	149	44	outcome	outcome	NN
cord-017337-vq3edhxn	149	45	Early	early	JJ
cord-017337-vq3edhxn	149	46	changes	change	NNS
cord-017337-vq3edhxn	149	47	in	in	IN
cord-017337-vq3edhxn	149	48	organ	organ	NN
cord-017337-vq3edhxn	149	49	function	function	NN
cord-017337-vq3edhxn	149	50	predict	predict	VBP
cord-017337-vq3edhxn	149	51	eventual	eventual	JJ
cord-017337-vq3edhxn	149	52	survival	survival	NN
cord-017337-vq3edhxn	149	53	in	in	IN
cord-017337-vq3edhxn	149	54	severe	severe	JJ
cord-017337-vq3edhxn	149	55	sepsis	sepsis	NN
cord-017337-vq3edhxn	150	1	Sepsis	sepsis	NN
cord-017337-vq3edhxn	150	2	mortality	mortality	NN
cord-017337-vq3edhxn	150	3	prediction	prediction	NN
cord-017337-vq3edhxn	150	4	based	base	VBN
cord-017337-vq3edhxn	150	5	on	on	IN
cord-017337-vq3edhxn	150	6	predisposition	predisposition	NN
cord-017337-vq3edhxn	150	7	,	,	,
cord-017337-vq3edhxn	150	8	infection	infection	NN
cord-017337-vq3edhxn	150	9	and	and	CC
cord-017337-vq3edhxn	150	10	response	response	NN
cord-017337-vq3edhxn	151	1	The	the	DT
cord-017337-vq3edhxn	151	2	ventilator	ventilator	NN
cord-017337-vq3edhxn	151	3	-	-	HYPH
cord-017337-vq3edhxn	151	4	associated	associate	VBN
cord-017337-vq3edhxn	151	5	pneumonia	pneumonia	NN
cord-017337-vq3edhxn	151	6	PIRO	PIRO	NNP
cord-017337-vq3edhxn	151	7	score	score	NN
cord-017337-vq3edhxn	151	8	:	:	:
cord-017337-vq3edhxn	151	9	a	a	DT
cord-017337-vq3edhxn	151	10	tool	tool	NN
cord-017337-vq3edhxn	151	11	for	for	IN
cord-017337-vq3edhxn	151	12	predicting	predict	VBG
cord-017337-vq3edhxn	151	13	ICU	ICU	NNP
cord-017337-vq3edhxn	151	14	mortality	mortality	NN
cord-017337-vq3edhxn	151	15	and	and	CC
cord-017337-vq3edhxn	151	16	health	health	NN
cord-017337-vq3edhxn	151	17	-	-	HYPH
cord-017337-vq3edhxn	151	18	care	care	NN
cord-017337-vq3edhxn	151	19	resources	resource	NNS
cord-017337-vq3edhxn	151	20	use	use	VBP
cord-017337-vq3edhxn	151	21	in	in	IN
cord-017337-vq3edhxn	151	22	ventilator	ventilator	NN
cord-017337-vq3edhxn	151	23	-	-	HYPH
cord-017337-vq3edhxn	151	24	associated	associate	VBN
cord-017337-vq3edhxn	151	25	pneumonia	pneumonia	NN
cord-017337-vq3edhxn	151	26	Clinical	clinical	JJ
cord-017337-vq3edhxn	151	27	trials	trial	NNS
cord-017337-vq3edhxn	151	28	of	of	IN
cord-017337-vq3edhxn	151	29	immunomodulatory	immunomodulatory	JJ
cord-017337-vq3edhxn	151	30	therapies	therapy	NNS
cord-017337-vq3edhxn	151	31	in	in	IN
cord-017337-vq3edhxn	151	32	severe	severe	JJ
cord-017337-vq3edhxn	151	33	sepsis	sepsis	NN
cord-017337-vq3edhxn	151	34	and	and	CC
cord-017337-vq3edhxn	151	35	septic	septic	JJ
cord-017337-vq3edhxn	151	36	shock	shock	NN
cord-017337-vq3edhxn	151	37	TNM	TNM	NNP
cord-017337-vq3edhxn	151	38	Classifi	Classifi	NNP
cord-017337-vq3edhxn	151	39	cation	cation	NN
cord-017337-vq3edhxn	151	40	of	of	IN
cord-017337-vq3edhxn	151	41	Malignant	malignant	JJ
cord-017337-vq3edhxn	151	42	Tumours	tumour	NNS