id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270213-ygb64yxc	Williams, Alexander T.	Control of systemic inflammation throughearly nitric oxide supplementation with nitric oxide releasing nanoparticles	2020-10-02		.txt	text/plain	2300	138	42	Given that endothelial dysfunction is a common denominator in many acute inflammatory conditions, it is likely that NO enhancement strategies may be useful for the treatment of sepsis and other acute inflammatory insults that trigger severe systemic pro-inflammatory responses and often result in a cytokine storm, as seen in COVID-19. A well-described hallmark of sepsis is endothelial dysfunction in response to a cytokine 81 'storm', which is associated with an increase in a series of negative consequences arising from 82 overproduction of reactive oxygen species (ROS), disruption of the glycocalyx, and endothelial 83 nitric oxide synthase (eNOS) uncoupling, all contributing to increased adhesion of red blood 84 cells (RBCs), white blood cells (WBCs), and platelets to the endothelium lining, enhanced 85 platelet activation, blood stagnation, decreased tissue perfusion and increased vascular 86 permeability. Mice treated with Control-np in our study 382 experienced significantly increased vascular permeability, as shown in Figure 4 , suggesting 383 endothelial cell and glycocalyx disruption in these animals.	./cache/cord-270213-ygb64yxc.txt	./txt/cord-270213-ygb64yxc.txt