id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252859-zir02q69	Chung, T. Philip	Molecular Diagnostics in Sepsis: From Bedside to Bench	2006-09-11		.txt	text/plain	5735	299	47	BACKGROUND: Based on recent in vitro data, we tested the hypothesis that microarray expression profiles can be used to diagnose sepsis, distinguishing in vivo between sterile and infectious causes of systemic inflammation. Lists of genes with substantial changes in expression between study and control groups were used to identify nine mouse common inflammatory response genes, six of which were mapped into a single pathway using contemporary pathway analysis tools. 17, 18 We hypothesized that leukocyte gene expression profiles obtained using DNA microarrays could be used to predict septic states; in particular, distinguishing between sterile and infectious sources of systemic inflammation, a common conundrum in caring for the critically ill or injured. 30 PCA analysis of these 25 probe sets revealed that the seven experimental groups were clustered into three apparent phenotypes (Fig. 4) : control animals, LPS-treated animals (sterile source of systemic inflammation), and those that had any CLP treatment (Sepsis).	./cache/cord-252859-zir02q69.txt	./txt/cord-252859-zir02q69.txt