id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018840-ts2g1ux7	Katragkou, Aspasia	Role of Immunoglobulin Therapy to Prevent and Treat Infections	2018-06-19		.txt	text/plain	6703	329	32	While the main clinical applications of immunoglobulin therapy concern their use as replacement for patients with primary immunodeficiencies, or as treatment for autoimmune and inflammatory disorders, their role in infectious disease is limited largely to viral and toxin neutralization and replacement therapy in patients with immunoglobulin deficiencies. The first clinical trial, which evaluated the effect of IgMA-enriched immunoglobulin preparation (7.8 g IgM, 7.8 g IgA, and 49.4 g IgG), which have shown to contain superior antibody content against bacterial lipopolysaccharides, in an appreciable number of neutropenic patients with hematologic malignancies and sepsis or septic shock, showed that immunoglobulins had no beneficial effects [51] . A controlled trial of long-term administration of intravenous immunoglobulin to prevent late infection and chronic graft-vs.-host disease after marrow transplantation: clinical outcome and effect on subsequent immune recovery	./cache/cord-018840-ts2g1ux7.txt	./txt/cord-018840-ts2g1ux7.txt