id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017376-wrhkfcff	Liu, Yongjian	Pro-resolution of Inflammation: New Hints to Manage Sepsis?	2019-05-28		.txt	text/plain	6209	310	35	Carbon monoxide, synthesized by HO-1, performs multiple stances of anti-inflammation and pro-resolution along with the SPMs. If the potentially beneficial effects of these mediators would be well evaluated in clinical trials, they present encouraging new hints in managing infectious maladies especially sepsis. Previous studies have shown that IV administration of RvD2 on a CLP sepsis model exhibits the following protective pro-resolution effects and increases survival rate: (1) reduce viable aerobic bacterial load in peritoneal exudates and blood; (2) reduce PMN migration into the peritoneum; (3) reduce plasma levels of IL-10 and IL-17; (4) reduce pro-inflammatory cytokine (IL-6, IL-1β, IL-23 and TNF-α) levels in plasma and peritoneum; (5) reduce concentrations of the pro-inflammatory lipids PGE2 and LTB4; while (6) increase clearance of bacteria by phagocytes in inguinal lymph nodes and in vitro; (7) enhance phagocytosis of E.	./cache/cord-017376-wrhkfcff.txt	./txt/cord-017376-wrhkfcff.txt