id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017337-vq3edhxn	Vincent, Jean-Louis	PIRO: The Key to Success?	2009		.txt	text/plain	3809	176	47	Building on a system that had emerged at the Fifth Toronto Sepsis Roundtable held in Toronto, Canada, in 2000 [6] , the sepsis defi nitions conference participants, therefore, proposed the PIRO system [5] , which can classify patients on the basis of their predisposing conditions, the nature and extent of the infection, the nature and magnitude of the host response, and the degree of concomitant organ dysfunction. The PIRO system for the grading of sepsis uses clinical and laboratory parameters to aid diagnosis and patient classifi cation, with each element being divided according to the degree of involvement (e.g., infection can be classifi ed as localized, extended, or generalized; immune response can be classifi ed as limited, extensive, or excessive; organ dysfunction can be classifi ed as mild, moderate, severe). Improved classifi cation of septic patients using the PIRO system may, thus, facilitate the development and evaluation of clinical trials of sepsis therapies and will also encourage further study into the pathophysiology and epidemiology of sepsis.	./cache/cord-017337-vq3edhxn.txt	./txt/cord-017337-vq3edhxn.txt