id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016127-tbot0fc9	Hurtado, F. J.	Sepsis: Clinical Approach, Evidence-Based at the Bedside	2009-11-19		.txt	text/plain	4875	315	44	Since 2002 the Surviving Sepsis Campaign was introduced with the initial goal of increasing clinicians' awareness about severe sepsis mortality and to improve outcome in this patient population. Despite the fact that most of these recommendations were not supported by high levels of evidence, they represented the international consensus on the best available standards of care for the management of sepsis. Mortality increases according to the presence of shock, and metabolic markers like arterial lactate are useful to characterize disease severity and the response to treatment [8] . The current management of severe sepsis and septic shock aims to control infection, achieve hemodynamic stabilization, modulate the immune response, and provide metabolic and organ support. The SSC is a global initiative that involves several international organizations with the common objective of elaborating evidence-based guidelines and recommendations for the management of severe sepsis and septic shock. Early goal-directed therapy in the treatment of severe sepsis and septic shock	./cache/cord-016127-tbot0fc9.txt	./txt/cord-016127-tbot0fc9.txt