id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-014658-oeuvelb1	Martin, Greg S.	Optimal fluid management in sepsis	2019-11-07		.txt	text/plain	888	45	45	Fluid administration should be targeted to achieve a MAP of at least 65 mm Hg, and to normalize lactate in patients with elevated lactate due to hypoperfusion.(3) Balanced crystalloids are the fluid of first choice for sepsis resuscitation based on ready availability and taking medication costs into account. Use of 0.9% saline compared to a balanced crystalloid, such as lactated Ringer's or PlasmaLyte, produces more kidney dysfunction and with a greater risk of dying.(4) The individual side effect profiles may best differentiate the natural and synthetic colloids. Albumin may be considered for administration to sepsis patients with refractory shock or who have received substantial amounts of crystalloid fluids, but should not be administered to patients with severe traumatic brain injury.(5) Hydroxyethyl starch (HES) products should not be administered to patients with sepsis because of increased risk of acute kidney injury and death.	./cache/cord-014658-oeuvelb1.txt	./txt/cord-014658-oeuvelb1.txt