id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006460-3ayc0hne	Baue, Arthur E.	Multiple organ failure – the discrepancy between our scientific knowledge and understanding and the management of our patients	2000-10-19		.txt	text/plain	8379	558	56	Here, then, is an example of a Nobel Prize being awarded for the study of endothelial A.E. Baue ( ✉ ) cell-produced NO on the one hand, and the concept of excess vasodilatation in septic shock, the hypothesis that this was due to NO and a clinical trial blocking NO that increased mortality on the other. 3. We have tried to lump together and treat human abnormalities according to symptoms and signs rather than to the basic causes of their diseases -we have tried to treat inflammation, sepsis, systemic inflammatory response syndrome (SIRS), and multiple organ dysfunction syndrome (MODS) rather than what caused them; perforated diverticulitis is not acute pancreatitis and neither are ventilator-associated pneumonia and appendicitis. There has been significant improvement in survival of patients with persistent severe organ system failure." Thus, this report confirms again (1) that better intensive care is helping, and (2) my insistence that the secret to MOF is prevention.	./cache/cord-006460-3ayc0hne.txt	./txt/cord-006460-3ayc0hne.txt