id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006426-baf2d47y	Kimura, Fumio	Immunosuppression following surgical and traumatic injury	2010-08-26		.txt	text/plain	9852	569	37	Suppression of cell-mediated immunity may be caused by multifaceted cytokine/inhibitor profiles in the circulation and other compartments of the host, excessive activation and dysregulated recruitment of polymorphonuclear neutrophils, induction of alternatively activated or regulatory macrophages that have anti-inflammatory properties, a shift in the T-helper (Th)1/Th2 balance toward Th2, appearance of regulatory T cells, which are potent suppressors of the innate and adaptive immune system, and lymphocyte apoptosis in patients with sepsis. 13, 14 In response to major tissue injury and/or bacterial infection, endothelial and epithelial cells, as well as neutrophils, macrophages, and lymphocytes, produce powerful proinfl ammatory cytokines, especially tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6.	./cache/cord-006426-baf2d47y.txt	./txt/cord-006426-baf2d47y.txt