id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005697-l1zmrq4p	Pène, Frédéric	Is this critically ill patient immunocompromised?	2015-12-02		.txt	text/plain	1344	67	29	A subset of septic patients infected with highly virulent pathogens may die rapidly from refractory shock, disseminated intravascular coagulation, and intractable multiple organ failure as a result of hyper-cytokinemia and uncontrolled inflammatory response. However, with improvements in acute care and resuscitation therapies, this classical exuberant presentation is relatively rare nowadays, and the physician is more often challenged by a blunted clinical response to infection, with subtle findings including lethargy or depressed mental status, glucose intolerance and hyperglycemia, hypothermia, and/or a change in the white blood cell count or cell differential. In addition to overt immunosuppressive conditions (e.g., cancer and hematological malignancies, solid organ transplant, autoimmune and systemic diseases, HIV, use of immunosuppressive drugs), many septic patients commonly exhibit additional risk factors affecting immune status [3] . Regardless of underlying comorbidities and primary injuries responsible for ICU admission, a significant proportion of critically ill patients can reasonably be considered to be immunocompromised and at risk for ICU-acquired infections, especially if they develop overt signs of immunosuppression.	./cache/cord-005697-l1zmrq4p.txt	./txt/cord-005697-l1zmrq4p.txt