id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355912-ioihqf0r	Shomuradova, A. S.	SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors	2020-05-25		.txt	text/plain	8632	494	57	Here we assayed both antibody and T-cell reactivity to SARS-CoV-2 antigens in COVID-19 convalescent patients and healthy donors sampled before and during the pandemic. 20.20107813 doi: medRxiv preprint Analysis of the humoral immune response to SARS-CoV-2 demonstrated that the IgG antibodies of the majority of COVID-19 -CPs were specific to one or more viral antigens. To describe the structure and clonality of SARS-CoV-2 directed T-cell immune response we performed analysis of T-cell receptor (TCR) repertoires of FACS-sorted IFNγ-secreting CD8+/CD4+ cells and MHC-tetramer-positive populations as well as the total fraction of PBMC by high throughput sequencing using the Illumina platform. Two patients (p1472 and p1473) had no detectable antibody levels in the serum to any of the tested SARS-CoV-2 antigens and no T-cellular response to any of the peptide pools, albeit they had T-cells reactive to the recombinant S-protein.	./cache/cord-355912-ioihqf0r.txt	./txt/cord-355912-ioihqf0r.txt