id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355788-6hteott0	Shirvani, Edris	Newcastle Disease Virus as a Vaccine Vector for SARS-CoV-2	2020-07-29		.txt	text/plain	4090	220	50	In this regard, Newcastle disease virus (NDV), an avian virus, has several well-suited properties for development of a vector vaccine against SARS-CoV-2. Currently, a number of DNA and RNA virus vector platforms are under evaluation for a SARS-CoV-2 vaccine, including attenuated vaccinia virus, replication-defective adenovirus, vesicular stomatitis virus, human parainfluenza viruses, and alphavirus replicons. Keeping these limitations in mind, we think Newcastle disease virus (NDV), as avian virus, has a number of characteristics that make it suitable for use as a vaccine vector for SARS-CoV-2. The effectiveness of NDV-vectored vaccines has already been evaluated against SARS-CoV in monkeys [8] , against MERS-CoV in camels [9] , and against avian infectious bronchitis virus (IBV) in chickens, a natural host challenge model [10] . Immunization of primates with a Newcastle disease virus-vectored vaccine via the respiratory tract induces a high titer of serum neutralizing antibodies against highly pathogenic avian influenza virus	./cache/cord-355788-6hteott0.txt	./txt/cord-355788-6hteott0.txt