id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355306-fj8utkfe	Xia Chao, Yin	The role of IgA in COVID-19	2020-05-23		.txt	text/plain	832	52	51	Secretory IgA plays a crucial role in the immune defense of mucosal surfaces, the first point of entry of SARS-CoV-2. Reported serology tests focus on IgM, IgG and total immunoglobulins although IgA is playing an important role in mucosal immunity. As an immune barrier, secretory IgA can neutralize SARS-CoV-2 before they reach and bind the epithelial cells (Figure1) . Mucosal vaccine targeting SARS-CoV-2 RBD given via oral or nasal targets to induce secretion of IgA within the mucosa may be a therapeutic strategy for preventing COVID-19 development. Plasma cells, which can be the target of mucosal vaccine, produce IgA and secreted into the mucus where they meet and neutralize the invaded virus through binding to the Spike protein on the surface of SARS-Cov-2. Other neutralization antibodies can also bind to SARS-Cov-2 to prevent it from infecting other cells.	./cache/cord-355306-fj8utkfe.txt	./txt/cord-355306-fj8utkfe.txt