id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-354893-tku1dr32	Shi, Zhengli	Evolution of SARS Coronavirus and the Relevance of Modern Molecular Epidemiology	2010-12-24		.txt	text/plain	5894	259	52	Comparative genome sequence analysis indicated that SARS-CoVs civets experience rapid ongoing mutation, suggesting that the viruses were still adapting to the host rather than persisting in equilibrium expected for viruses in their natural reservoir species Song et al., 2005) . Analysis of all the viral sequences available from human patients and animals revealed two major hallmarks of rapid virus evolution during the initial stages of the 2002À2003 outbreaks: (1) All isolates from early patients and market animals contained a 29-nt sequence in ORF8 that is absent in most of the publicly available human SARS-CoV sequences derived from later phases of the outbreaks; (2) a characteristic motif of single-nucleotide variations (SNVs) were identified in SARS-CoV of different phases, and all these SNVs were located in the S gene that codes for the spike protein responsible for attachment to host cellular receptor . Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections	./cache/cord-354893-tku1dr32.txt	./txt/cord-354893-tku1dr32.txt