id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352935-kb0i58z1	Aguila, Enrik John T.	Repurposed GI Drugs in the Treatment of COVID-19	2020-06-29		.txt	text/plain	990	63	49	A recent drug research in Germany has shown that omeprazole interfered viral formation of SARS-CoV-2 beyond therapeutic plasma concentrations at 8 µM [6] . To date, there is still little knowledge on the potential of famotidine and omeprazole as repurposed drugs to treat COVID-19. In their letter, Aguila and colleagues provide an insight into commonly used acid suppressants such as famotidine and omeprazole as the potential agents for drug repurposing against COVID-19. The role of famotidine in interfering maturation of SARS-CoV-2 by inhibiting 2-chymotrypsin-like protein and reduction in inflammation needs to be studied. The authors also note that omeprazole at therapeutic concentration increased the anti-SARS-CoV-2 effects of remdesivir and aprotinin. Therefore, there is a theoretical concern that the use of H2-blockers and PPIs could diminish or abolish the neutralizing effects of gastric acid on SARS-CoV-2, which could potentially increase the risk of GI manifestations and severity in COVID-19.	./cache/cord-352935-kb0i58z1.txt	./txt/cord-352935-kb0i58z1.txt