id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352863-6cttilm8	Hennighausen, Lothar	Activation of the SARS-CoV-2 receptor Ace2 through JAK/STAT-dependent enhancers during pregnancy	2020-09-06		.txt	text/plain	3450	197	55	Expression of the ACE2 gene in type II pneumocytes is activated by interferons (Ziegler et al., 2020) , opening the possibility that the cytokine storm in COVID-19 patients, and peptide hormones in general, might lead to increased levels of ACE2 in a range of putative SARS-CoV-2 target tissues. Next, we mined RNA-seq data from our lab and demonstrated increased Ace2 expression throughout pregnancy and lactation ( Figure 1B ) with a pattern similar to that of other prolactin-regulation genes (Lee et al., 2018; Yamaji et al., 2013) . Our study directly demonstrates that the Ace2 gene is expressed in mammary tissue and activated during pregnancy and lactation through intronic enhancers built on the transcription factor STAT5. While SARS-CoV-2 has been detected in breast milk in at least seven studies and our research has demonstrated that its receptor ACE2 is present in mammary tissue and highly induced during lactation, the impact of these findings on COVID-19 requires further investigations.	./cache/cord-352863-6cttilm8.txt	./txt/cord-352863-6cttilm8.txt