id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352796-6einbent	Theodore Coroneo, Minas	The eye as the discrete but defensible portal of coronavirus infection	2020-05-21		.txt	text/plain	5340	259	44	The virus may bind to corneal and conjunctival angiotensin converting enzyme 2 (ACE2) receptors and potentially to the lipophilic periocular skin and superficial tear film with downstream carriage into the nasopharynx and subsequent access to the lungs and gut. A combination such as hydroxychloroquine, azithromycin and zinc, all of which have previously been used topically in the eye and which work at least in part by blocking ACE2 receptors, may offer a safe, cost-effective and resource-sparing intervention. At the height of the 1918 world influenza epidemic, a landmark paper appeared, proposing transmission of acute respiratory infections via the eye and lacrimal-nasal pathway (5) (Figure 1) . Table 2 summarises the drugs that have been identified as potential treatments for coronavirus infection, their efficacy (in vitro and in vivo) and for which there is data (for that agent or a related compound) for previous topical ocular surface usage.	./cache/cord-352796-6einbent.txt	./txt/cord-352796-6einbent.txt