id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-351224-jeedo5mc	GeurtsvanKessel, Corine H.	An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment	2020-07-06		.txt	text/plain	3046	153	46	The Wantai ELISA detecting total immunoglobulins against the receptor binding domain of SARS CoV-2, has the best overall characteristics to detect functional antibodies in different stages and severity of disease, including the potential to set a cut-off indicating the presence of protective antibodies. Despite the differences in sensitivity, all laboratory assays had sufficient positive predictive value (PPV) in COVID-19 hospitalized patients when assuming an expected seroprevalence in this population of ≥50% (Table 1) , or when using serology as an adjunct to RT-PCR testing to monitor the clinical course of illness. To determine specificity of the assays, we used a well-defined panel of 147 serum and plasma samples from 147 individuals exposed to human coronaviruses (HCoV-229E, NL63 or OC43), SARS, MERS), or with a range of other respiratory viruses ( Sensitivity was calculated by using a total of 187 sera from 107 individuals in the Netherlands, in whom COVID-19 was confirmed by RT-PCR and antibodies were detected by PRNT50.	./cache/cord-351224-jeedo5mc.txt	./txt/cord-351224-jeedo5mc.txt