id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-350733-0zghspb8	Aronson, Jeffrey K.	The use of mechanistic reasoning in assessing coronavirus interventions	2020-07-15		.txt	text/plain	4461	265	42	RATIONALE: Evidence‐based medicine (EBM), the dominant approach to assessing the effectiveness of clinical and public health interventions, focuses on the results of association studies. That treatment for hypertension is a risk factor for severe disease in the case of SARS-CoV-2 suggests that altering hypertension treatment might alleviate disease, but the mechanisms are complex, and it is essential to consider and evaluate more than one mechanistic hypothesis (Section 3). This strategy makes much use of evidence from mechanistic studies: evidence that the drug has some action against the novel virus in the laboratory, both in vitro and in vivo in experimental animals, is used to justify the decision to use the treatment clinically. Some evidence, for instance, supports a behavioural mechanism known as the "intention-behaviour gap," 53 In sum, the explicit and systematic assessment of mechanistic studies is essential for the development of effective vaccination programs in a given context.	./cache/cord-350733-0zghspb8.txt	./txt/cord-350733-0zghspb8.txt