id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-350309-j4oh1z8m	Liu, D. X.	Coronavirus envelope protein: A small membrane protein with multiple functions	2007-05-29		.txt	text/plain	3403	167	48	The E proteins from infectious bronchitis virus (IBV) and mouse hepatitis virus (MHV) are translated from the third and second ORFs of mRNA 3 and 5 of the respective viruses by a cap-independent, internal ribosomal entry mechanism [6] [7] [8] [9] [10] [11] [12] . This modification is unique to SARS-CoV E protein, and it is still unknown whether the modification can also be detected in virus-infected cells and in virions. However, the membrane topologies of SARS-CoV E protein in virions and in virusinfected cells are still unknown. Similar to other viroporins [46] , expression of SARS-CoV and MHV E protein enhanced the membrane permeability of bacterial and mammalian cells [47, 48] . These results indicate that the ion channel activity of coronavirus E protein is important for virus replication, especially in the case of some coronaviruses, such as MHV. Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells	./cache/cord-350309-j4oh1z8m.txt	./txt/cord-350309-j4oh1z8m.txt