id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349417-vn7q8wc4	Ziebuhr, John	The Coronavirus Replicase: Insights into a Sophisticated Enzyme Machinery	2006		.txt	text/plain	3379	179	45	Activation of the coronavirus replication complex involves extensive proteolytic processing of the replicase polyproteins to produce 16 (in IBV: 15) mature products called nonstructural proteins (nsp) 1 to 16 (reviewed in Refs. The N-terminal regions of the coronavirus polyproteins, which are poorly conserved among the coronavirus groups I, II, and III, are cleaved at two (in IBV) or three sites (in all other coronaviruses) by one (IBV and SARS-CoV) or two zinc-finger-containing papain-like cysteine proteases called PL1 pro and PL2 pro . The observed pattern of conservation in different nidovirus families suggests a functional hierarchy for the newly identified RNA-processing activities, with the manganese ion-dependent uridylate-specific endoribonuclease, NendoU, playing a central role. Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication	./cache/cord-349417-vn7q8wc4.txt	./txt/cord-349417-vn7q8wc4.txt