id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349089-ta07bho2	Antushevich, Hanna	Interplays between inflammasomes and viruses, bacteria (pathogenic and probiotic), yeasts and parasites	2020-09-22		.txt	text/plain	8174	467	34	For example, in in vitro experiments on human primary neurons (HPNs) and microglial cells (HFMG) collected from healthy patients, it was discovered that treatment of the cells with HIV ssRNA40 (specific GU-rich single-stranded RNA from the HIV long terminal repeat region) activates the NLRP3 inflammasome and increases the expression and extracellular secretion of pro-inflammatory cytokines (IL-1β, IL-18) and neurotoxic cytokines (TNF-α, IL-1α, C1q). Another report has shown that HIV-1 induces the expression of NLRP3 inflammasome and IL-1β secretion in dendritic cells from healthy individuals but not HIV-1-infected patients, suggesting that inflammasome activation contributes to disease progression [23] . Based on the strong inflammatory potential of the NLRP3 inflammasome during infections caused by MERS-and SARS-CoVs, inhibition of the NLRP3 inflammasome activity may attenuate the cytokine storm and be a therapeutic target in the treatment of tissue inflammation in SARS patients [33, 41] .	./cache/cord-349089-ta07bho2.txt	./txt/cord-349089-ta07bho2.txt