id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349031-tbof9yqi	Chen, Shiu-Jau	Novel Antiviral Strategies in the Treatment of COVID-19: A Review	2020-08-20		.txt	text/plain	5464	303	43	Fortunately, some novel antiviral strategies, such as convalescent plasma, clustered regularly interspaced short palindromic repeats (CRISPR), and mesenchymal stem cell (MSC) therapy, potentially offer an additional or alternative option or compassionate use for the people suffering from COVID-19, especially for critically ill patients, although their safety and efficacy are also under study. In this review, we explore the applications, possible mechanisms, and efficacy in successful cases using convalescent plasma, CRISPR, and MSC therapy for COVID-19 treatment, respectively. In this case series study of five critically ill patients with COVID-19 and ARDS, the administration of convalescent plasma containing neutralizing antibodies significantly improved their clinical status [53] . Under the condition that traditional drugs cannot assure their safety and efficacy for COVID-19 treatment, novel antiviral strategies, including convalescent plasma, CRISPR, and cell therapy, may be able to provide an additional or alternative option or compassionate use for the treatment of COVID-19, particular for critically ill patients.	./cache/cord-349031-tbof9yqi.txt	./txt/cord-349031-tbof9yqi.txt