id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-348723-sf073cmj	Chen, Liang	The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2	2020-03-30		.txt	text/plain	2015	104	51	title: The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2 Angiotensin-converting enzyme 2 (ACE2), the key host cellular receptor of SARS-CoV-2, has been identified in multiple organs, but its cellular distribution in human heart is not illuminated clearly. This study performed the first state-of-art single cell atlas of adult human heart, and revealed that pericytes with high expression of ACE2 might act as the target cardiac cell of SARS-CoV-2. The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2. In the present study, we investigated ACE2 expression in the adult human hearts from healthy and diseased individuals, to illuminate the potential capacity of heart infection by SARS-CoV-2. This result suggested that pericyte was a potential SARS-CoV-2 virus targeted host cell type in the human heart.	./cache/cord-348723-sf073cmj.txt	./txt/cord-348723-sf073cmj.txt