id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-348065-0tkx7aas	Liu, Bing	Persistent SARS-CoV-2 presence is companied with defects in adaptive immune system in non-severe COVID-19 patients	2020-03-30		.txt	text/plain	2285	124	54	Methods 37 non-severe patients with persistent SARS-CoV-2 presence transferred to Zhongnan hospital of Wuhan University were retrospectively recruited to PP (persistently positive) group, which was further allocated to PPP group (n=19) and PPN group (n=18), according to their testing results after 7 days (N=negative). Conclusion Persistent SARS-CoV-2 presence in non-severe COVID-19 patients is associated with reduced numbers of adaptive immune cells. Next, we determined the abnormalities for each parameters Lymphopenia was observed at illness onset in 72.8% of non-severe COVID-19 patients (the PA group) in our study, which is similar to those reported by Zhang et al [15] (75.4%), Mo et al [17] (73.5%), Wang et al [27] (70.3%), and Guan et al [2] (83.2%), suggesting the involvement of lymphocytes in the early phase of SARS-CoV-2 infection. Together, these results suggest that measurement of these lymphocyte subpopulations could be used to distinguish non-severe patients with persistent viral presence from healthy subjects and those turned negative, and thus have clinical relevance for discharge management.	./cache/cord-348065-0tkx7aas.txt	./txt/cord-348065-0tkx7aas.txt