id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347818-93ixqyfp	Hojyo, Shintaro	How COVID-19 induces cytokine storm with high mortality	2020-10-01		.txt	text/plain	4508	214	39	Thus, IL-6 serves as a possible mechanism of treatment for severe COVID-19 patients, raising the possibility that one therapeutic option for the disease may be targeting excessive inflammation caused by IL-6 receptor (IL-6R) signaling with monoclonal antibody therapy or treatment with chemical modulators to block the signaling cascade while maintaining a sufficient antiviral primary immune response. IL-6-STAT3 signaling as a potential cause of the ARDS via cytokine storms in COVID-19 patients IL-6 amplifier, machinery for excessive inflammation SARS-CoV-2 infection induces the endocytosis of ACE2 together with SARS-CoV in target cells including epithelial cells and endothelial cells, resulting in an increase of serum angiotensin II (Ang II) levels due to the reduction of ACE2 surface expression (Fig. 1) [17, 48] .	./cache/cord-347818-93ixqyfp.txt	./txt/cord-347818-93ixqyfp.txt