id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-347366-0gier0lu	Gurwitz, David	Angiotensin receptor blockers as tentative SARS‐CoV‐2 therapeutics	2020-03-04		.txt	text/plain	1917	105	45	A tentative suggestion based on existing therapeutics, which would likely be resistant to new coronavirus mutations, is to use available angiotensin receptor 1 (AT1R) blockers, such as losartan, as therapeutics for reducing the aggressiveness and mortality from SARS‐CoV‐2 virus infections. These tentative suggestions were based on the observation that SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as the receptor binding domain for its spike protein (Lu et al., 2020; Wan, Shang, Graham, Baric, & Li, 2020) , similarly to the coronavirus strain implicated in the 2002-2003 SARS epidemic (Dimitrov, 2003; Ge et al., 2013; Li et al., 2003; Prabakaran et al 2004; Turner, Hiscox, & Hooper, 2004) . The tentative suggestion to apply AT1R antagonists such as losartan and telmisartan as SARS-CoV-2 therapeutics for treating patients prior to the development of acute respiratory syndrome remains unproven until tried.	./cache/cord-347366-0gier0lu.txt	./txt/cord-347366-0gier0lu.txt