id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346998-01i6zxv8	Kulkarni, Spoorthy	COVID-19 and hypertension	2020-05-20		.txt	text/plain	2584	163	48	COVID-19 seems to follow a pattern seen with influenza and previous severe acute respiratory syndrome coronavirus (SARS-CoV) outbreaks: that the severity and mortality of the infection is higher in the elderly age group. The controversy regarding continuing or discontinuing angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) in COVID-19 patients arose after it became apparent that SARS-CoV uses angiotensin-converting enzyme 2 (ACE2) to gain entry in host cells. 12 Consequently, the increased expression of ACE2 would facilitate an increased rate or susceptibility to infection with SARS-CoV-2 and further hypothesis that this may increase the risk of developing severe and fatal COVID-19. The study tested the hypothesis of an increased risk of severe illness in COVID-19 with hypertension with ACEi use (on ACEi n=37; not on ACEi n=168) in admitted patients. Effect of angiotensin converting enzyme gene I/D polymorphism and its expression on clinical outcome in acute respiratory distress syndrome	./cache/cord-346998-01i6zxv8.txt	./txt/cord-346998-01i6zxv8.txt