id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346445-hgqohdct	Toyoshima, Yujiro	SARS-CoV-2 genomic variations associated with mortality rate of COVID-19	2020-07-22		.txt	text/plain	3553	187	53	Our findings suggest that SARS-CoV-2 mutations as well as BCG-vaccination status and a host genetic factor, HLA genotypes might affect the susceptibility to SARS-CoV-2 infection or severity of COVID-19. In this study, we comprehensively analyzed 12,343 SARS-CoV-2 genome sequences isolated from patients/ individuals in six geographic areas, including Asia, North America, South America, Europe, Oceania, and Africa, and investigated their correlations to the fatality rates in 28 different countries. In this study, we investigated the SARS-CoV-2 virus mutations and found that the frequencies of S protein 614G variant and its highly linked variant, ORF1ab 4715L, were significantly correlated with fatality rates in the 28 countries and 17 states of the United States. In summary, we comprehensively investigated SARS-CoV-2 genome mutations, BCG-vaccination status, and HLA genotypes in the 28 different countries and identified significant associations of some virus genome variants with the fatality rates.	./cache/cord-346445-hgqohdct.txt	./txt/cord-346445-hgqohdct.txt