id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346403-fuxs1axy	Davanzo, G. G.	SARS-CoV-2 Uses CD4 to Infect T Helper Lymphocytes	2020-09-28		.txt	text/plain	3490	214	59	We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARSCoV-2 in T helper cells in a mechanism that also requires ACE2 and TMPRSS2. SARS-CoV-2 infected T helper cells express higher amounts of IL-10, which is associated with viral persistence and disease severity. SARS-CoV-2 infected T helper cells express higher amounts of IL-10, which is associated with viral persistence and disease severity. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may explain the poor adaptive immune response of many COVID-19 patients. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may explain the poor adaptive immune response of many COVID-19 patients. Since CD4 + T lymphocytes orchestrate innate and adaptive immune responses 19, 20 , infection of CD4 + T cells by SARS-CoV-2 might explain lymphocytopenia and dysregulated inflammatory response in severe COVID-19 patients.	./cache/cord-346403-fuxs1axy.txt	./txt/cord-346403-fuxs1axy.txt