id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345103-b2wkm03g	Yao, Hangping	Molecular architecture of the SARS-CoV-2 virus	2020-09-06		.txt	text/plain	5755	313	54	Here we report the molecular assembly of the authentic SARS-CoV-2 virus using cryo-electron tomography (cryo-ET) and subtomogram averaging (STA). The postfusion S observed on the SARS-CoV-2 virus may come from 1) products of occasional, spontaneous dissociation of S1 (Cai et al., 2020) , which was cleaved by host proteinases; 2) syncytium naturally formed on infected cells , when budding progeny virions carried a few residual postfusion S from the cell surface; 3) sample preparation procedure, as cryo-EM images of ßpropiolactone fixed viruses showed most spikes present on the virus are postfusion-like Gao et al., 2020) . Three representative SARS-CoV-2 virus (Figures 1B and 4D ) and a bundle of postfusion S ( Figure 3B ) were reconstructed by projecting all spikes and RNPs onto their refined coordinates and merging the structures using Jsubtomo (Huiskonen et al., 2014) . Structures and distributions of SARS-CoV-2 spike proteins on intact virions	./cache/cord-345103-b2wkm03g.txt	./txt/cord-345103-b2wkm03g.txt